bluuebunny/crossref_metadata_2025_split huggingface dataset:
O PROBLEMA DAS METÁFORAS NA CLÍNICA
Authors: Almeida Bruno Vasconcelos de , Nova Cruz Denise Viuniski da , Mostafa Solange Puntel 
Published: December 2017

<p>Este artigo problematiza o uso das metáforas na clínica médica e no ensino da clínica, extrapolando a questão para outros encontros terapêuticos, e destacando a importância da linguagem para as práticas de cuidado em saúde. Para isso, apresenta dois argumentos teóricos diferentes a respeito da metáfora, figura de linguagem tão significativa para diferentes áreas de conhecimento: argumentos contrários à utilização das metáforas resgatados do texto clássico de Susan Sontag – <em>Doença como Metáfora. AIDS e suas Metáforas</em>, e uma teorização poética favorável às metáforas como forma de expressão e representação de sentimentos de dor e de perda no pensamento de Anatole Broyard – <em>Intoxicated by my Illness and Other Writings on Life and Death</em>. Esses dois resgates teóricos são utilizados para demonstrar a relevância do problema para a prática da clínica. O artigo concentra-se na questão linguística e na literalidade no pensamento de Gilles Deleuze, alçando as metáforas ao domínio dos conceitos filosóficos.</p>
Application of Google-based Data for Travel Time Analysis: Kaunas City Case Study
Authors: Dumbliauskas Vytautas , Grigonis Vytautas , Barauskas Andrius 
Published: December 2017

Recently, new traffic data sources have emerged raising new challenges and opportunities when applying novel methodologies. The purpose of this research is to analyse car travel time data collected from smartphones by Google Company. Geographic information system (GIS) tools and Python programming language were employed in this study to establish the initial framework as well as to automatically extract, analyse, and visualize data. The analysis resulted in the calculation of travel time fluctuation during the day, calculation of travel time variability and estimation of origin-destination (OD) skim matrices. Furthermore, we accomplished the accessibility analysis and provided recommendations for further research.
Control of Luminescence by Tuning of Crystal Symmetry and Local Structure in Mn4+‐Activated Narrow Band Fluoride Phosphors
Authors: Fang Mu‐Huai , Wu Wei‐Lun , Jin Ye , Lesniewski Tadeusz , Mahlik Sebastian , Grinberg Marek , Brik Mikhail G. , Srivastava Alok M. , Chiang Chang‐Yang , Zhou Wuzong , Jeong Donghyuk , Kim Sun Hee , Leniec Grzegorz , Kaczmarek Slawomir M. , Sheu Hwo‐Shuenn , Liu Ru‐Shi 
Published: December 2017

AbstractMn4+‐doped fluoride phosphors have been widely used in wide‐gamut backlighting devices because of their extremely narrow emission band. Solid solutions of Na2(SixGe1−x)F6:Mn4+ and Na2(GeyTi1−y)F6:Mn4+ were successfully synthesized to elucidate the behavior of the zero‐phonon line (ZPL) in different structures. The ratio between ZPL and the highest emission intensity υ6 phonon sideband exhibits a strong relationship with luminescent decay rate. First‐principles calculations are conducted to model the variation in the structural and electronic properties of the prepared solid solutions as a function of the composition. To compensate for the limitations of the Rietveld refinement, electron paramagnetic resonance and high‐resolution steady‐state emission spectra are used to confirm the diverse local environment for Mn4+ in the structure. Finally, the spectral luminous efficacy of radiation (LER) is used to reveal the important role of ZPL in practical applications.
The Role of Mg(OH)2 in the So‐Called “Base‐Free” Oxidation of Glycerol with AuPd Catalysts
Authors: Fu Jile , He Qian , Miedziak Peter J. , Brett Gemma L. , Huang Xiaoyang , Pattisson Samuel , Douthwaite Mark , Hutchings Graham J. 
Published: December 2017

AbstractMg(OH)2‐ and Mg(OH)2‐containing materials can provide excellent performance as supports for AuPd nanoparticles for the oxidation of glycerol in the absence of base, which is considered to be a result of additional basic sites on the surface of the support. However, its influence on the reaction solution is not generally discussed. In this paper, we examine the relationship between the basic Mg(OH)2 support and AuPd nanoparticles in detail using four types of catalyst. For these reactions, the physical interaction between Mg(OH)2 and AuPd was adjusted. It was found that the activity of the AuPd nanoparticles increased with the amount of Mg(OH)2 added under base‐free conditions, regardless of its interaction with the noble metals. In order to investigate how Mg(OH)2 affected the glycerol oxidation, detailed information about the performance of AuPd/Mg(OH)2, physically mixed (AuPd/C+Mg(OH)2) and (AuPd/C+NaHCO3) was obtained and compared. Furthermore, NaOH and Mg(OH)2 were added during the reaction using AuPd/C. All these results indicate that the distinctive and outstanding performance of Mg(OH)2 supported catalysts in base‐free condition is in fact directly related to its ability to affect the pH during the reaction and as such, assists with the initial activation of the primary alcohol, which is considered to be the rate determining step in the reaction.
Heterogeneous expression and biological function of SOX18 in osteosaroma
Authors: Zhu Danjie , Yang Di , Li Xiaolin , Feng Fabo 
Published: December 2017

AbstractOsteosaroma (OS) is a primary bone malignancy and is associated with high morbidity. Sex determining region Y‐box 18 (SOX18) is identified overexpressed in OS. However, the molecular mechanism underlying the biological function of SOX18 in OS is still unclear. The aim of the current study was to determine the SOX18 expression in patients with OS and its effect on tumor cell malignant phenotypes. Our results showed that SOX18 was overexpressed in OS patients from both E‐MEXP‐3628 database and independent samples from our hospital and in OS cell lines. SOX18 silencing significantly induced G0‐G1 phase cell cycle arrest and apoptosis and inhibited U‐2OS cell migration and invasion and cell growth both in vitro and in vivo. However, SOX18 overexpression remarkably promoted 143B cell proliferation, migration and invasion and inhibited cell cycle arrest and apoptosis. The protein expression levels of p53, p21, Bax, Bcl‐2, and Caspase‐3 were also regulated by SOX18. Moreover, SOX18 was found negative correlated with the expression of HERC1, HER2, HERC3, HERC4, HERC5, and HERC6 in OS patients and in OS cells, with the most significant correlation detected in HERC2 expression, which was following found interacted with SOX18 in OS cells. Taken together, our results suggest that SOX18 is overexpressed in OS and plays an important role in proliferation, apoptosis, migration and invasion of OS cells, and may provide a novel and promising thera­peutic strategy for OS.
Mechanistic effects of mesenchymal and hematopoietic stem cells: New therapeutic targets in myocardial infarction
Authors: Shafei Ayman El‐Sayed , Ali Mahmoud A. , Ghanem Hazem G. , Shehata Ahmed I. , Abdelgawad Ahmed A. , Handal Hossam R. , ElSayed Abdelfatah S. , Ashaal Ahmed E. , Ali Mazen M. , El‐Shal Amal S. 
Published: December 2017

AbstractMyocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is of the most serious health threats today. Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been explored as promising cell therapy in MI and regenerative therapy. Recently, reports investigated the potential therapeutic effects of MSCs or HSCs transplantation after MI in numerous experimental and clinical studies; however, their results are controversy and needs more explorations. The current review is an attempt to clarify the therapeutic potentials of MSCs and HSCs in MI therapy, as well as their possible effects; especially the paracrine one and the exosome‐derived stem cell among animal models as well as clinical trials conducted within the last 10 years. In this context, various sources of MSCs and HSCs have been addressed in helping cardiac regeneration by either revitalizing the cardiac stem cells niche or revascularizing the arteries and veins of the heart. In addition, both MSCs and HSCs could produce paracrine mediators and growth factors which led to cardiomyocytes protection, angiogenesis, immunemodulation, antioxidants, anti‐apoptotic, anti‐inflammatory, antifibrotic, as well as increasing cardiac contractility. Recently, microRNAs (miRNAs), post‐transcriptional regulators of gene expression, and long non‐coding RNA (lncRNA), a miRNA sponge, are recent stem cell‐derived mediators can be promising targets of MSCs and HSCs through their paracrine effects. Although MSCs and HSCs have achieved considerable achievements, however, some challenges still remain that need to be overcome in order to establish it as a successful technique. The present review clarified the mechanistic potentials of MSCs and HSCs especially paracrine effects involved in MI including human and animal studies and the challenges challenges regarding type, differentiation, route, and number of injections.
Coarse‐grained A‐graft‐B model of poly(lactic acid) for molecular dynamics simulations
Authors: Glagolev Mikhail , Glova Artyom , Mezhenskaia Daria , Falkovich Stanislav , Larin Sergey , Vasilevskaya Valentina , Lyulin Sergey 
Published: December 2017

ABSTRACTA mesoscopic model of poly(lactic acid) is developed where the polymer is represented as an A‐graft‐B chain with monomer units consisting of two covalently connected beads. A coarse‐graining algorithm is proposed to convert an atomistic model of PLA into a coarse‐grained one. The developed model is based on atomistic simulations of oligolactides to take into account terminal groups correctly. It was used for coarse‐grained simulations of polylactide. Gyration radii and end to end distances of polymer chains as well as the density of the polymer melt are shown to be in a good agreement with those obtained from atomistic simulations. The thermal expansion coefficients of the OLA melts calculated using the coarse‐grained model are in reasonable agreement with those obtained from all‐atom molecular dynamics. The model provides a 17‐fold speedup compared with atomistic calculations. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 604–612
Cognitive processing therapy for post-traumatic stress disorder in a University Counselling Center: an outcome study
Authors: Wilkinson Charity , von Linden Meghan , Wacha-Montes Annmarie , Bryan Craig , O'Leary Katherine 
Published: December 2017

AbstractMore than half of college students endorse experiencing at least one traumatic event. Consistent with other populations, the rate of post-traumatic stress disorder (PTSD) for college students has been reported at around 12%. Despite this, empirically supported treatments for PTSD have not been widely disseminated in University Counselling Centers (UCCs). This study examines outcomes using cognitive processing therapy (CPT) with a sample of n = 26 college students in a UCC setting. This study also examines therapist experience, length of degree and symptom severity on outcome. After completing training, n = 8 therapists completed CPT consultation and certification. Students who participated in individual CPT during this process were administered the PCL-5 and PHQ-9 at weekly sessions. A retrospective chart review was completed. PCL-5 and PHQ-9 scores were separately examined as outcome variables using linear mixed models where session, therapist experience, length of therapist degree, and severity of symptoms were included as fixed effects, and subjects were assumed to have a random effect. Significant reductions in PCL-5 and PHQ-9 scores were observed across treatment. In this sample, 84.6% of students were treatment responders. Results were unchanged when adjusting for therapist level of experience or training. CPT shows strong potential for UCC settings. CPT can be successfully implemented with novice therapists.
Regulatory Chill in a Warming World: The Threat to Climate Policy Posed by Investor-State Dispute Settlement
Authors: Tienhaara Kyla 
Published: December 2017

AbstractThe system of investor-state dispute settlement (ISDS) found in over 3,000 bilateral investment treaties and numerous regional trade agreements has been criticized for interfering with the rights of sovereign states to regulate investment in the public interest, for example, to protect the environment and public health. This article argues that while much of the public debate around ISDS has focused on a small number of cases that have arisen over the regulation of tobacco packaging, there is a far greater threat posed by the potential use of ISDS by the fossil fuel industry to stall action on climate change. It is hypothesized that fossil fuel corporations will emulate a tactic employed by the tobacco industry – that of using ISDS to induce cross-border regulatory chill: the delay in policy uptake in jurisdictions outside the jurisdiction in which the ISDS claim is brought. Importantly, fossil fuel corporations do not have to win any ISDS cases for this strategy to be effective; they only have to be willing to launch them. The article concludes with three options to reform trade and investment agreements to better align them with climate change mitigation efforts: (i) exclude ISDS provisions; (ii) prohibit fossil fuel industries from accessing ISDS; or (iii) carve out all government measures taken in pursuit of international obligations (for example, under the Paris Agreement on climate change) from challenge under ISDS.
The Neurology of Immune-Mediated Disorders in Women
Authors: Vodopivec Ivana 
Published: December 2017

AbstractMany neuroinflammatory disorders have a predilection for women; even if there is no female predominance, neuroinflammatory conditions in women pose a management challenge for several reasons. Disease activity of these conditions may change during pregnancy and commonly increases in the postpartum period. Uncontrolled disease activity may affect pregnancy outcomes. Moreover, immunomodulating agents that are used to suppress the disease activity may have a negative impact on fertility, pregnancy, and fetal outcomes, and on infants who are breastfed. Adverse effects of immunosuppressants extend beyond the reproductive issues and may include bone loss, increased risk of cancers, and infectious complications. The successful management of women with these disorders requires that not only practitioners understand and recognize the adverse effects of immunosuppressants, but also seek to prevent adverse outcomes through counseling about contraceptive choices, safety monitoring, risk surveillance, and other strategies.
Combined Volar and Dorsal Approach for Fixation of Comminuted Intra-Articular Distal Radial Fractures
Authors: Smith M. , Johnstone A. , Medlock G. 
Published: December 2017

Purpose Multifragmentary intra-articular fractures displaced in multiple planes are a challenge. We use a reproducible technique of fracture and articular reduction using an initial volar approach targeting reduction in the volar lunate facet first with plate and unicortical locking screws. This creates a template for reduction in dorsal fragments through a dorsal approach. Our study investigated the radiological, clinical, and functional outcomes of patients treated with this technique.
Materials and Methods We reviewed the postoperative radiographs and notes of 18 patients that had this method of fixation between the years 2008 and 2015, the mean age being 43. These patients were reviewed functionally on average 2 years and 3 months following their definitive operation.
Results Normal alignment and length to the distal radius were restored with on average a 0.6 mm articular step. The average range of motion was 64% and preservation of grip strength was 71% compared with the uninjured wrist. Functional assessment averages were 29 for both the quick Disabilities of the Arm, Shoulder and Hand (DASH) and for Patient Rated Wrist Evaluation. The modified system of Green and O'Brien had results of good in 10, fair in 7, and poor in 1. With respect to the Gartland and Werley system, three patients had an excellent result, four had a good result, six had a fair result, and five had a poor result. The mean arthritic grading was 1 (grading 0–3) according to Knirk and Jupiter.
Conclusion This reproducible technique provides an option for these devastating fractures providing a functioning wrist with all of the patients returning to their original form of employment.
Schmerzen vor dem Ohr – ist die Ursache immer das Kiefergelenk? Ein Fallbericht
Authors: Hoffmann Marisa , Trouw Michiel 
Published: December 2017

ZusammenfassungMareike
1
hat Schmerzen im Kiefergelenk. Ihre Vorgeschichte ist komplex. Anhand einer
ausführlichen, strukturierten Untersuchung wird deutlich, dass das Hauptproblem in der kranioneuralen Region liegt. Manuelle Therapie
verändert die Beweglichkeit und den neurologischen Befund, interkraniale Techniken verbessern den Zustand weiter. Neben Hands-on Techniken
sind aktive Übungen und Selbstmanagement ebenso wichtig für den weiteren Erfolg der Therapie.
Behandlungsmöglichkeiten der Kokzygodynie aus Sicht der Manuellen Therapie
Authors: Harlacher A. , Möller D. , von Piekartz H. 
Published: December 2017

ZusammenfassungSchmerzen im Bereich des Steißbeins werden häufig unter dem Begriff
Kokzygodynie
zusammengefasst. Ursache der Beschwerden
können hierbei lokal oder entfernt liegende Strukturen sein. Außerdem gibt es eine Reihe von inneren und psychischen Erkrankungen, die eine
Kokzygodynie vortäuschen können und differenzialdiagnostisch abgeklärt werden müssen.Dieser Artikel gibt eine Übersicht über Anatomie, Ätiopathologie, Diagnostik, Differenzialdiagnostik und Therapiemöglichkeiten bei
Kokzygodynie. Der Schwerpunkt liegt dabei auf muskuloskeletaler Therapie. Es werden Techniken am Steißbein aus 4 manualtherapeutischen
Konzepten vorgestellt.
Ontological function annotation of long non-coding RNAs through hierarchical multi-label classification
Authors: Zhang Jingpu , Zhang Zuping , Wang Zixiang , Liu Yuting , Deng Lei 
Published: December 2017

Abstract

Motivation
Long non-coding RNAs (lncRNAs) are an enormous collection of functional non-coding RNAs. Over the past decades, a large number of novel lncRNA genes have been identified. However, most of the lncRNAs remain function uncharacterized at present. Computational approaches provide a new insight to understand the potential functional implications of lncRNAs.

Results
Considering that each lncRNA may have multiple functions and a function may be further specialized into sub-functions, here we describe NeuraNetL2GO, a computational ontological function prediction approach for lncRNAs using hierarchical multi-label classification strategy based on multiple neural networks. The neural networks are incrementally trained level by level, each performing the prediction of gene ontology (GO) terms belonging to a given level. In NeuraNetL2GO, we use topological features of the lncRNA similarity network as the input of the neural networks and employ the output results to annotate the lncRNAs. We show that NeuraNetL2GO achieves the best performance and the overall advantage in maximum F-measure and coverage on the manually annotated lncRNA2GO-55 dataset compared to other state-of-the-art methods.

Availability and implementation
The source code and data are available at http://denglab.org/NeuraNetL2GO/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?
Authors: Stack Jonathan P , Moslehi Javid , Sayed Nazish , Wu Joseph C 
Published: December 2017

Abstract
Cardiotoxic effects from cancer therapy are a major cause of morbidity during cancer treatment. Unexpected toxicity can occur during treatment and/or after completion of therapy, into the time of cancer survivorship. While older drugs such as anthracyclines have well-known cardiotoxic effects, newer drugs such as tyrosine kinase inhibitors, proteasome inhibitors, and immunotherapies also can cause diverse cardiovascular and metabolic complications. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly being used as instruments for disease modelling, drug discovery, and mechanistic toxicity studies. Promising results with hiPSC-CM chemotherapy studies are raising hopes for improving cancer therapies through personalized medicine and safer drug development. Here, we review the cardiotoxicity profiles of common chemotherapeutic agents as well as efforts to model them in vitro using hiPSC-CMs.
Implications of late-in-life density-dependent growth for fishery size-at-entry leading to maximum sustainable yield
Authors: van Gemert Rob , Andersen Ken H 
Published: December 2017

AbstractCurrently applied fisheries models and stock assessments rely on the assumption that density-dependent regulation only affects processes early in life, as described by stock–recruitment relationships. However, many fish stocks also experience density-dependent processes late in life, such as density-dependent adult growth. Theoretical studies have found that, for stocks which experience strong late-in-life density dependence, maximum sustainable yield (MSY) is obtained with a small fishery size-at-entry that also targets juveniles. This goes against common fisheries advice, which dictates that primarily adults should be fished. This study aims to examine whether the strength of density-dependent growth in actual fish stocks is sufficiently strong to reduce optimal fishery size-at-entry to below size-at-maturity. A size-structured model is fitted to three stocks that have shown indications of late-in-life density-dependent growth: North Sea plaice (Pleuronectes platessa), Northeast Atlantic (NEA) mackerel (Scomber scombrus), and Baltic sprat (Sprattus sprattus balticus). For all stocks, the model predicts exploitation at MSY with a large size-at-entry into the fishery, indicating that late-in-life density dependence in fish stocks is generally not strong enough to warrant the targeting of juveniles. This result lends credibility to the practise of predominantly targeting adults in spite of the presence of late-in-life density-dependent growth.
Selecting for three copepods—feeding of sprat and herring in the Baltic Sea
Authors: Ojaveer Henn , Lankov Ain , Raid Tiit , Põllumäe Arno , Klais Riina 
Published: December 2017

AbstractPredator–prey interactions are a primary structuring force in marine foodwebs and they play an important role in the dynamics of both marine fish populations and their prey. We investigated the individual and spatial patterns in the feeding of two dominant zooplanktivorous clupeids—herring Clupea harengus membras and sprat Sprattus sprattus—in the Baltic Sea in summer, by means of a taxonomic analysis of stomach content. Both species consumed predominantly the small-sized copepods (Temora longicornis, Eurytemora affinis, and Acartia spp.). E. affinis and T. longicornis were generally positively selected by both species. Centropages hamatus was selected only by sprat. With the exception of Pleopis/Podon spp. in the case of small sprat, the remaining prey, i.e. the zooplankton taxa that were found in fish stomachs, were consumed at similar proportions as they occurred in zooplankton. Stomach fullness of fish increased with the increasing proportions of prey in the zooplankton community. The share of empty stomachs was lower for sprat, and among smaller fish in both species. Pairwise dietary overlap between fish decreased when zooplankton diversity increased. Dietary overlap was also lowest among the individuals of sprat, probably due to the wider diet spectrum and diversity of stomach content compared to herring. Our results point to high interspecific competition, where sprat seems to be more successful than herring in finding and consuming prey, and therefore may have an advantage over herring when the zooplankton community is dominated by small-sized taxa.