bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct measurement of individual phonon lifetimes in the clathrate compound Ba7.81Ge40.67Au5.33
Authors: Lory Pierre-François , Pailhès Stéphane , Giordano Valentina M. , Euchner Holger , Nguyen Hong Duong , Ramlau Reiner , Borrmann Horst , Schmidt Marcus , Baitinger Michael , Ikeda Matthias , Tomeš Petr , Mihalkovič Marek , Allio Céline , Johnson Mark Robert , Schober Helmut , Sidis Yvan , Bourdarot Frédéric , Regnault Louis Pierre , Ollivier Jacques , Paschen Silke , Grin Yuri , de Boissieu Marc 
Published: September 2017

AbstractEngineering lattice thermal conductivity requires to control the heat carried by atomic vibration waves, the phonons. The key parameter for quantifying it is the phonon lifetime, limiting the travelling distance, whose determination is however at the limits of instrumental capabilities. Here, we show the achievement of a direct quantitative measurement of phonon lifetimes in a single crystal of the clathrate Ba7.81Ge40.67Au5.33, renowned for its puzzling ‘glass-like’ thermal conductivity. Surprisingly, thermal transport is dominated by acoustic phonons with long lifetimes, travelling over distances of 10 to 100 nm as their wave-vector goes from 0.3 to 0.1 Å−1. Considering only low-energy acoustic phonons, and their observed lifetime, leads to a calculated thermal conductivity very close to the experimental one. Our results challenge the current picture of thermal transport in clathrates, underlining the inability of state-of-the-art simulations to reproduce the experimental data, thus representing a crucial experimental input for theoretical developments.
Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality
Authors: Sugizaki Taichi , Zhu Shunshun , Guo Ge , Matsumoto Akiko , Zhao Jiabin , Endo Motoyoshi , Horiguchi Haruki , Morinaga Jun , Tian Zhe , Kadomatsu Tsuyoshi , Miyata Keishi , Itoh Hiroshi , Oike Yuichi 
Published: September 2017

AbstractA favorable effect of an inhibitor of the sodium–glucose cotransporter 2 (SGLT2i) on mortality of diabetic patients was recently reported, although mechanisms underlying that effect remained unclear. Here, we examine SGLT2i effects on survival of diabetic mice and assess factors underlying these outcomes. To examine SGLT2i treatment effects in a model of severe diabetes, we fed genetically diabetic db/db mice a high-fat diet and then assessed outcomes including diabetic complications between SGLT2i TA-1887-treated and control mice. We also compare effects of SGLT2i TA-1887 with those of lowering blood glucose levels via insulin treatment. Untreated db/db mice showed remarkable weight loss, or cachexia, while TA-1887-treated mice did not but rather continued to gain weight at later time points and decreased mortality. TA-1887 treatment prevented pancreatic beta cell death, enhanced preservation of beta cell mass and endogenous insulin secretion, and increased insulin sensitivity. Moreover, TA-1887 treatment attenuated inflammation, oxidative stress, and cellular senescence, especially in visceral white adipose tissue, and antagonized endothelial dysfunction. Insulin treatment of db/db mice also prevented weight loss and antagonized inflammation and oxidative stress. However, insulin treatment had less potent effects on survival and prevention of cellular senescence and endothelial dysfunction than did TA-1887 treatment. SGLT2i treatment prevents diabetic cachexia and death by preserving function of beta cells and insulin target organs and attenuating complications. SGLT2i treatment may be a promising therapeutic strategy for type 2 diabetes patients with morbid obesity and severe insulin resistance.
Clinical outcomes in patients with node-negative breast cancer treated based on the recurrence score results: evidence from a large prospectively designed registry
Authors: Stemmer Salomon M. , Steiner Mariana , Rizel Shulamith , Soussan-Gutman Lior , Ben-Baruch Noa , Bareket-Samish Avital , Geffen David B. , Nisenbaum Bella , Isaacs Kevin , Fried Georgeta , Rosengarten Ora , Uziely Beatrice , Svedman Christer , McCullough Debbie , Maddala Tara , Klang Shmuel H. , Zidan Jamal , Ryvo Larisa , Kaufman Bella , Evron Ella , Karminsky Natalya , Goldberg Hadassah , Shak Steven , Liebermann Nicky 
Published: September 2017

AbstractThe 21-gene Recurrence Score® (RS) assay is a validated prognostic/predictive tool in ER + early-stage breast cancer. However, clinical outcome data from prospective studies in RS ≥ 11 patients are lacking, as are relevant real-life clinical practice data. In this retrospective analysis of a prospectively designed registry, we evaluated treatments/clinical outcomes in patients undergoing RS-testing through Clalit Health Services. The analysis included N0 ER + HER2-negative breast cancer patients who were RS-tested from 1/2006 through 12/2010. Medical records were reviewed to verify treatments/recurrences/survival. The cohort included 1801 patients (median follow-up, 6.2 years). Median age was 60 years, 50.4% were grade 2 and 81.1% had invasive ductal carcinoma; 48.9% had RS < 18, 40.7% RS 18–30, and 10.4% RS ≥ 31, with chemotherapy use of 1.4, 23.7, and 87.2%, respectively. The 5-year Kaplan–Meier estimates for distant recurrence were 0.8, 3.0, and 8.6%, for patients with RS < 18, RS 18–30 and RS ≥ 31, respectively; the corresponding 5-year Kaplan–Meier estimates for breast cancer death were 0.0, 0.9, and 6.2%. Chemotherapy-untreated patients with RS < 11 (n = 304) and 11–25 (n = 1037) (TAILORx categorization) had 5-year Kaplan–Meier estimates for distant recurrence risk/breast cancer death of 1.0%/0.0% and 1.3%/0.4%, respectively. Our results extend those of the prospective TAILORx trial: the 5-year Kaplan–Meier estimates for distant recurrence and breast cancer death rate for the RS < 18 patients were very low supporting the use of endocrine therapy alone. Furthermore, in chemotherapy-untreated patients with RS 11–25 (where TAILORx patients were randomized to chemoendocrine or endocrine therapy alone), 5-year distant recurrence rates were also very low, suggesting that chemotherapy would not have conferred clinically meaningful benefit.
Realization of tunable artificial synapse and memory based on amorphous oxide semiconductor transistor
Authors: Dai Mingzhi , Wang Weiliang , Wang Pengjun , Iqbal Muhammad Zahir , Annabi Nasim , Amin Nasir 
Published: September 2017

AbstractRecently, advanced designs and materials emerge to study biologically inspired neuromorphic circuit, such as oxide semiconductor devices. The existence of mobile ions in the oxide semiconductors could be somewhat regarded to be similar with the case of the ions movements among the neurons and synapses in the brain. Most of the previous studies focus on the spike time, pulse number and material species: however, a quantitative modeling is still needed to study the voltage dependence of the relaxation process of synaptic devices. Here, the gate pulse stimulated currents of oxide semiconductor devices have been employed to mimic and investigate artificial synapses functions. The modeling for relaxation process of important synaptic behaviors, excitatory post-synaptic current (EPSC), has been updated as a stretched-exponential function with voltage factors in a more quantitative way. This quantitative modeling investigation of representative synaptic transmission bias impacts would help to better simulate, realize and thus control neuromorphic computing.
Effects of low concentrations of erythromycin, penicillin, and virginiamycin on bacterial resistance development in vitro
Authors: Ge Beilei , Domesle Kelly J. , Yang Qianru , Young Shenia R. , Rice-Trujillo Crystal L. , Bodeis Jones Sonya M. , Gaines Stuart A. , Keller Marla W. , Li Xin , Piñeiro Silvia A. , Whitney Brooke M. , Harbottle Heather C. , Gilbert Jeffrey M. 
Published: September 2017

AbstractDistillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mutants were induced in one Campylobacter coli and one Enterococcus faecium strain, while these strains plus three additional C. coli, one additional E. faecium, and one C. jejuni also developed resistance when exposed to 0.25 µg/ml erythromycin. At 0.5 µg/ml erythromycin, a total of eight strains (four Campylobacter and four Enterococcus) obtained macrolide-resistant mutants, including two strains from each genus that were not selected at lower erythromycin concentrations. For penicillin, three of five E. faecium strains but none of five Enterococcus faecalis strains consistently developed resistance at all three selection concentrations. Virginiamycin at two M1:S1 ratios did not induce resistance development in four out of five E. faecium strains; however, increased resistance was observed in the fifth one under 0.25 and 0.5 µg/ml virginiamycin selections. Although not yet tested in vivo, these findings suggest a potential risk of stimulating bacterial resistance development in the animal gut when distillers grains containing certain antibiotic residues are used in animal feed.
Body Fat Distribution and the Risk of Incident Metabolic Syndrome: A Longitudinal Cohort Study
Authors: Kwon Hyuktae , Kim Donghee , Kim Joo Sung 
Published: September 2017

AbstractThe effect of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) area on metabolic syndrome (MS) has been debated. We aimed to evaluate the effects of VAT and SAT on the incidence of MS and its components in a large and apparently healthy Asian population. We performed a longitudinal cohort study of 1,964 subjects who received health screenings over a 5-year follow-up period; 317 incidents of MS (16.1%) were observed during a median follow-up of 4.5 years. The VAT area was significantly associated with a higher incidence of MS; the adjusted HR for incident MS per 1 SD of VAT was 1.50 (95% CI 1.29–1.74), and the adjusted HR of the 5th VAT quintile compared with the 1st quintile was 3.73 (95% CI 2.22–6.28). However, the SAT area was not associated with incident MS. Although the VAT area was longitudinally associated with the incidence of each component of MS, the SAT area was inversely associated with the risk of high blood pressure, fasting blood sugar, and triglycerides, with marginal significance. In conclusion, the VAT area is longitudinally associated with an increased risk of incident MS, while SAT may have a protective effect against the incidence of individual MS components.
Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain
Authors: Elramah Sara , López-González María José , Bastide Matthieu , Dixmérias Florence , Roca-Lapirot Olivier , Wielanek-Bachelet Anne-Cécile , Vital Anne , Leste-Lasserre Thierry , Brochard Alexandre , Landry Marc , Favereaux Alexandre 
Published: September 2017

AbstractStrong breakthrough pain is one of the most disabling symptoms of cancer since it affects up to 90% of cancer patients and is often refractory to treatments. Alteration in gene expression is a known mechanism of cancer pain in which microRNAs (miRNAs), a class of non-coding regulatory RNAs, play a crucial role. Here, in a mouse model of cancer pain, we show that miR-124 is down-regulated in the spinal cord, the first relay of the pain signal to the brain. Using in vitro and in vivo approaches, we demonstrate that miR-124 is an endogenous and specific inhibitor of synaptopodin (Synpo), a key protein for synaptic transmission. In addition, we demonstrate that Synpo is a key component of the nociceptive pathways. Interestingly, miR-124 was down-regulated in the spinal cord in cancer pain conditions, leading to an up-regulation of Synpo. Furthermore, intrathecal injections of miR-124 mimics in cancerous mice normalized Synpo expression and completely alleviated cancer pain in the early phase of the cancer. Finally, miR-124 was also down-regulated in the cerebrospinal fluid of cancer patients who developed pain, suggesting that miR-124 could be an efficient analgesic drug to treat cancer pain patients.
Second-generation Flagellin-rPAc Fusion Protein, KFD2-rPAc, Shows High Protective Efficacy against Dental Caries with Low Potential Side Effects
Authors: Yang Jingyi , Sun Ying , Bao Rong , Zhou Dihan , Yang Yi , Cao Yuan , Yu Jie , Zhao Bali , Li Yaoming , Yan Huimin , Zhong Maohua 
Published: September 2017

AbstractDental caries is one of the most common global chronic diseases affecting all ages of the population; thus a vaccine against caries is urgently needed. Our previous studies demonstrated that a fusion protein, KF-rPAc, in which rPAc of S. mutans is directly fused to the C-terminal of E. coli-derived flagellin (KF), could confer high prophylactic and therapeutic efficiency against caries. However, possible side effects, including the high antigenicity of flagellin and possible inflammatory injury induced by flagellin, may restrict its clinical usage. Here, we produced a second-generation flagellin-rPAc fusion protein, KFD2-rPAc, by replacing the main antigenicity region domains D2 and D3 of KF with rPAc. Compared with KF-rPAc, KFD2-rPAc has lower TLR5 agonist efficacy and induces fewer systemic inflammatory responses in mice. After intranasal immunization, KFD2-rPAc induces significantly lower flagellin-specific antibody responses but a comparable level of rPAc-specific antibody responses in mice. More importantly, in rat challenge models, KFD2-rPAc induces a robust rPAc-specific IgA response, and confers efficient prophylactic and therapeutic efficiency against caries as does KF-rPAc, while the flagellin-specific antibody responses are highly reduced. In conclusion, low side effects and high protective efficiency against caries makes the second-generation flagellin-rPAc fusion protein, KFD2-rPAc, a promising vaccine candidate against caries.
In vivo pH measurement at the site of calcification in an octocoral
Authors: Le Goff C. , Tambutté E. , Venn A. A. , Techer N. , Allemand D. , Tambutté S. 
Published: September 2017

AbstractCalcareous octocorals are ecologically important calcifiers, but little is known about their biomineralization physiology, relative to scleractinian corals. Many marine calcifiers promote calcification by up-regulating pH at calcification sites against the surrounding seawater. Here, we investigated pH in the red octocoralCorallium rubrumwhich forms sclerites and an axial skeleton. To achieve this, we cultured microcolonies on coverslips facilitating microscopy of calcification sites of sclerites and axial skeleton. Initially we conducted extensive characterisation of the structural arrangement of biominerals and calcifying cells in context with other tissues, and then measured pH by live tissue imaging. Our results reveal that developing sclerites are enveloped by two scleroblasts and an extracellular calcifying medium of pH 7.97 ± 0.15. Similarly, axial skeleton crystals are surrounded by cells and a calcifying medium of pH 7.89 ± 0.09. In both cases, calcifying media are more alkaline compared to calcifying cells and fluids in gastrovascular canals, but importantly they are not pH up-regulated with respect to the surrounding seawater, contrary to what is observed in scleractinians. This points to a potential vulnerability of this species to decrease in seawater pH and is consistent with reports that red coral calcification is sensitive to ocean acidification.
Sulfonolipids as novel metabolite markers of Alistipes and Odoribacter affected by high-fat diets
Authors: Walker Alesia , Pfitzner Barbara , Harir Mourad , Schaubeck Monika , Calasan Jelena , Heinzmann Silke S. , Turaev Dmitrij , Rattei Thomas , Endesfelder David , Castell Wolfgang zu , Haller Dirk , Schmid Michael , Hartmann Anton , Schmitt-Kopplin Philippe 
Published: September 2017

AbstractThe gut microbiota generates a huge pool of unknown metabolites, and their identification and characterization is a key challenge in metabolomics. However, there are still gaps on the studies of gut microbiota and their chemical structures. In this investigation, an unusual class of bacterial sulfonolipids (SLs) is detected in mouse cecum, which was originally found in environmental microbes. We have performed a detailed molecular level characterization of this class of lipids by combining high-resolution mass spectrometry and liquid chromatography analysis. Eighteen SLs that differ in their capnoid and fatty acid chain compositions were identified. The SL called “sulfobacin B” was isolated, characterized, and was significantly increased in mice fed with high-fat diets. To reveal bacterial producers of SLs, metagenome analysis was acquired and only two bacterial genera, i.e., Alistipes and Odoribacter, were revealed to be responsible for their production. This knowledge enables explaining a part of the molecular complexity introduced by microbes to the mammalian gastrointestinal tract and can be used as chemotaxonomic evidence in gut microbiota.
Heightened aversion to risk and loss in depressed patients with a suicide attempt history
Authors: Baek Kwangyeol , Kwon JaeHyung , Chae Jeong-Ho , Chung Yong An , Kralik Jerald D. , Min Jung-Ah , Huh HyuJung , Choi Kyung Mook , Jang Kuk-In , Lee Na-Bin , Kim Sunyoung , Peterson Bradley S. , Jeong Jaeseung 
Published: September 2017

AbstractSuicide attempters have been found to be impaired in decision-making; however, their specific biases in evaluating uncertain outcomes remain unclear. Here we tested the hypothesis that suicidal behavior is associated with heightened aversion to risk and loss, which might produce negative predictions about uncertain future events. Forty-five depressed patients with a suicide attempt history, 47 nonsuicidal depressed patients, and 75 healthy controls participated in monetary decision-making tasks assessing risk and loss aversion. Suicide attempters compared with the other groups exhibited greater aversion to both risk and loss during gambles involving potential loss. Risk and loss aversion correlated with each other in the depressed patients, suggesting that a common pathophysiological mechanism underlies these biases. In addition, emotion regulation via suppression, a detrimental emotional control strategy, was positively correlated with loss aversion in the depressed patients, also implicating impairment in regulatory processes. A preliminary fMRI study also found disrupted neural responses to potential gains and losses in the subgenual anterior cingulate cortex, insula cortex, and left amygdala, brain regions involved in valuation, emotion reactivity, and emotion regulation. The findings thus implicate heightened negative valuation in decision-making under risk, and impaired emotion regulation in depressed patients with a history of suicide attempts.
RNAseq revealed the important gene pathways controlling adaptive mechanisms under waterlogged stress in maize
Authors: Arora Kanika , Panda Kusuma Kumari , Mittal Shikha , Mallikarjuna Mallana Gowdra , Rao Atmakuri Ramakrishna , Dash Prasanta Kumar , Thirunavukkarasu Nepolean 
Published: September 2017

AbstractWaterlogging causes yield penalty in maize-growing countries of subtropical regions. Transcriptome analysis of the roots of a tolerant inbred HKI1105 using RNA sequencing revealed 21,364 differentially expressed genes (DEGs) under waterlogged stress condition. These 21,364 DEGs are known to regulate important pathways including energy-production, programmed cell death (PCD), aerenchyma formation, and ethylene responsiveness. High up-regulation ofinvertase(49-fold) andhexokinase(36-fold) in roots explained the ATP requirement in waterlogging condition. Also, high up-regulation ofexpansins(42-fold),plant aspartic protease A3(19-fold),polygalacturonases(16-fold),respiratory burst oxidase homolog(12-fold), andhydrolases(11-fold) explained the PCD of root cortical cells followed by the formation of aerenchyma tissue during waterlogging stress. We hypothesized that the oxygen transfer in waterlogged roots is promoted by a cross-talk of fermentative, metabolic, and glycolytic pathways that generate ATPs for PCD and aerenchyma formation in root cortical cells. SNPs were mapped to the DEGs regulating aerenchyma formation (12), ethylene-responsive factors (11), and glycolysis (4) under stress. RNAseq derived SNPs can be used in selection approaches to breed tolerant hybrids. Overall, this investigation provided significant evidence of genes operating in the adaptive traits such as ethylene production and aerenchyma formation to cope-up the waterlogging stress.
Radial arrangement of apical adhesive sites promotes contact self-alignment of fruits in Commicarpus plants (Nyctaginaceae)
Authors: Filippov Alexander E. , Gorb Elena V. , Gorb Stanislav N. 
Published: September 2017

AbstractFruits of the plants from the genus Commicarpus (Nyctaginaceae) use their adhesive properties for dispersal. They can readily stick to various surfaces including skin, fur, and feathers of potential dispersal vectors using the secretion provided by the set of glands arranged radially at the distal end of the cut-cone-shaped fruit. Field observations show that this particular geometry promotes self-alignment of the fruit to various surfaces after initial contact just by one gland is established. Such self-alignment in turn leads to an increase of the number of contacting points and to the enhancement of adhesive contact area. Here, we study this particular geometry from a theoretical point of view, by probing adhesion ability of geometries having from 2 to 7 radially distributed attachment points. The results show that the radial arrangement provides rapid alignment to the surface. The robust adhesion can be reached already at 5 adhesive points and their further increase does not substantially improve the performance. This study is important not only for our understanding of the functional morphology of biological adhesive systems, but also for the development of technical self-aligning adhesive devices.
Analysis of mutual couplings in a concentric circular ring plasmonic optical antenna array
Authors: Gu Guiru , Li Lin , Zhang Yingjie , Kemsri Thitikorn , Lu Xuejun 
Published: September 2017

AbstractIn this paper, we report the analysis of a concentric circular ring plasmonic optical antenna (POA) array using a simple lumped coupled circuit (LCC) model. The currents in the circular rings of the POA array and their mutual couplings are analyzed using the LCC model. The results agree well with the numerical simulation using CST’s Microwave Studio®. The LCC model reveals the mutual couplings between the antenna rings. It is found that the mutual couplings are not only between the adjacent antenna rings, but also involve their second (2nd) nearest or farther neighbors. Since the near-fields of the optical antennas are related to the currents in the optical antennas, the LCC model provides a useful tool for the analysis of the near-field and their mutual interactions in the circular ring POA array.