bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Electronic Consultation System to Improve Access to Care in Pediatric Hematology/Oncology
Authors: Johnston Donna L. , Murto Kimmo , Kurzawa Julia , Liddy Clare , Keely Erin , Lai Lillian 
Published: April 2017

Background:
Electronic consultations (eConsult) allow for communication between primary care providers and specialists in an asynchronous manner. This study examined provider satisfaction, topics of interest, and efficiency of eConsult in pediatric hematology/oncology in Ottawa, Canada.

Methods:
We conducted a cross-sectional assessment of all eConsult cases directed to pediatric hematology/oncology specialists using the Champlain BASE (Building Access to Specialists through eConsultation) eConsult service from June 1, 2014 to May 31, 2016.

Results:
There were 1064 eConsults to pediatrics during the study timeperiod and pediatric hematology/oncology consults accounted for 8% (85). During the same study timeperiod, 524 consults were seen in the pediatric hematology/oncology clinic. The majority of the eConsults were for hematology (90.5%) in contrast to oncology topics (9.5%). The most common topics were anemia, hemoglobinopathy, bleeding disorder, and thrombotic state. Primary care providers rated the eConsult service very highly, and their comments were very positive. The eConsult service resulted in deferral of 40% of consults originally contemplated to require a face-to-face specialist visit.

Conclusions:
This study showed successful implementation and use of the eConsult service for pediatric hematology/oncology and resulted in avoidance of a large number of face-to-face consultation. The common topics identified areas for continuing medical education.
Mean Levels and Variability in Affect, Diabetes Self-Care Behaviors, and Continuously Monitored Glucose: A Daily Study of Latinos With Type 2 Diabetes
Authors: Wagner Julie , Armeli Stephen , Tennen Howard , Bermudez-Millan Angela , Wolpert Howard , Pérez-Escamilla Rafael 
Published: April 2017

ABSTRACT

Objective
This study investigated between- and within-person associations among mean levels and variability in affect, diabetes self-care behaviors, and continuously monitored glucose in Latinos with type 2 diabetes.

Methods
Fifty participants (M [SD] age = 57.8 [11.7] years, 74% women, mean [SD] glycosylated hemoglobin A1c = 8.3% [1.5%]) wore a “blinded” continuous glucose monitor for 7 days, and they responded to twice daily automated phone surveys regarding positive affect, negative affect, and self-care behaviors.

Results
Higher mean levels of NA were associated with higher mean glucose (r = .30), greater percent hyperglycemia (r = .34) and greater percentage of out-of-range glucose (r = .34). Higher NA variability was also related to higher mean glucose (r = .34), greater percent of hyperglycemia (r = .44) and greater percentage of out-of-range glucose (r = .43). Higher positive affect variability was related to lower percentage of hypoglycemia (r = −.33). Higher mean levels of self-care behaviors were related to lower glucose variability (r = −.35). Finally, higher self-care behavior variability was related to greater percentage of hyperglycemia (r = .31) and greater percentage of out-of-range glucose (r = −.28). In multilevel regression models, within-person increases from mean levels of self-care were associated with lower mean levels of glucose (b = −7.4, 95% confidence interval [CI] = −12.8 to −1.9), lower percentage of hyperglycemia (b = −0.04, 95% CI = −0.07 to −0.01), and higher percentage of hypoglycemia (b = 0.02, 95% CI = 0.01 to 0.03) in the subsequent 10-hour period.

Conclusions
Near-to-real time sampling documented associations of glucose with affect and diabetes self-care that are not detectable with traditional measures.
Unilateral Blindness After Septoplasty
Authors: Kilavuz Ahmet Erdem , Yildirim Duzgun , Serin Gediz Murat , Kaytaz Asim 
Published: April 2017

Abstract
Septoplasty is a frequently performed procedure with mostly minor complications. Nevertheless, it may lead to serious complications.
The authors present a 29-year-old patient admitted to their hospital 10 days after septoplasty in another institution. He suffered a total loss of vision immediately after the surgery.
High-resolution computed tomography and magnetic resonance imaging revealed a direct trauma of the optic canal and an inflamed and edematous optic nerve. Even though a successful endoscopic optic nerve was performed, the patient's loss of vision did not improve after the surgery.
Blindness after septoplasty is an extremely rare but a devastating complication. There are only few patients that indicates the optic nerve injury caused by a direct trauma.
Outcome for Patients With Pathological Esophageal Acid Exposure After Laparoscopic Fundoplication
Authors: Oor Jelmer E. , Nieuwenhuijs Vincent B. , Devitt Peter G. , Hazebroek Eric J. , Watson David I. 
Published: April 2017

Objective:
The aim of the current study was to assess symptomatic outcome and need for surgical reintervention for patients identified with pathological esophageal acid exposure by routine postoperative 24-hour pH-monitoring.

Background:
Although laparoscopic fundoplication is associated with excellent short- and midterm results, recurrent symptoms pose an important challenge. Postoperative pH-monitoring is considered the “gold standard” for diagnosing recurrent GERD and frequently used for routine postoperative follow up.

Methods:
Analysis of prospectively collected data from patients who underwent laparoscopic fundoplication between April 1994 and June 2015 and underwent routine postoperative 24-hour pH-monitoring was performed. Symptomatic outcome and need for surgical reintervention up to 5 years was compared between patients with pathological and physiological postoperative esophageal acid exposure. Primary endpoints were heartburn score and need for surgical reintervention for recurrent reflux.

Results:
A total of 309 patients in whom routine postoperative 24-hour pH-monitoring was performed were included. Pathological acid exposure was present in 33 patients (11%) compared with 276 patients (89%) with physiological acid exposure. During 5-year follow up, there were no differences in heartburn, dysphagia, or satisfaction scores. Eighteen percent of all patients with abnormal postoperative pH-studies underwent redo fundoplication during 5-year follow up.

Conclusions:
Pathological acid exposure demonstrated by routine postoperative pH-monitoring was not associated with worse symptomatic outcome in terms of reflux control and satisfaction. A possible explanation for this finding is that laparoscopic fundoplication reduces the patients’ ability to perceive reflux. This underlines the importance of assessing the association between symptomatic outcome and esophageal function tests in determining outcome of antireflux surgery.
An embryonic system to assess Wnt transcriptional targets
Authors: Suresh Jahnavi , Harmston Nathan , Lim Ka Keat , Kaur Prameet , Jin Helen Jingshu , Lusk Jay B. , Petretto Enrico , Tolwinski Nicholas S. 
Published: April 2017

AbstractDuring animal development, complex signals determine and organize a vast number of tissues using a very small number of signal transduction pathways. These developmental signaling pathways determine cell fates through a coordinated transcriptional response that remains poorly understood. The Wnt pathway is involved in a variety of these cellular functions, and its signals are transmitted in part through a β-catenin/TCF transcriptional complex. Here we report anin vivo Drosophilaassay that can be used to distinguish between activation, de-repression and repression of transcriptional responses, separating upstream and downstream pathway activation and canonical/non-canonical Wnt signals in embryos. We find specific sets of genes downstream of both β-catenin and TCF with an additional group of genes regulated by Wnt, while the non-canonical Wnt4 regulates a separate cohort of genes. We correlate transcriptional changes with phenotypic outcomes of cell differentiation and embryo size, showing our model can be used to characterize developmental signaling compartmentalizationin vivo.
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers ofC9orf72dipeptide repeat protein toxicity
Authors: Haney Michael S. , Kramer Nicholas J. , Morgens David W. , Jovičić Ana , Couthouis Julien , Li Amy , Ousey James , Ma Rosanna , Bieri Gregor , Bassik Michael C. , Gitler Aaron D. 
Published: April 2017

AbstractHexanucleotide repeat expansions in theC9orf72gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9FTD/ALS). The nucleotide repeat expansions are translated into dipeptide repeat (DPR) proteins, which are aggregation-prone and may contribute to neurodegeneration. Studies in model organisms, including yeast and flies have converged upon nucleocytoplasmic transport as one underlying pathogenic mechanism, but a comprehensive understanding of the molecular and cellular underpinnings of DPR toxicity in human cells is still lacking. We used the bacteria-derived clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system to perform genome-wide gene knockout screens for suppressors and enhancers ofC9orf72DPR toxicity in human cells. We validated hits by performing secondary CRISPR-Cas9 screens in primary mouse neurons. Our screens revealed genes involved in nucleocytoplasmic transport, reinforcing the previous findings from model systems. We also uncovered new potent modifiers of DPR toxicity whose gene products function in the endoplasmic reticulum (ER), proteasome, RNA processing pathways, and in chromatin modification. Since regulators of ER stress emerged prominently from the screens, we further investigated one such modifier,TMX2, which we identified as a modulator of the ER-stress signature elicited byC9orf72DPRs in neurons. Together, this work identifies novel suppressors of DPR toxicity that represent potential therapeutic targets and demonstrates the promise of CRISPR-Cas9 screens to define mechanisms of neurodegenerative diseases.One Sentence SummaryGenome-wide CRISPR-Cas9 screens in human cells reveal mechanisms and targets for ALS-associatedC9orf72dipeptide repeat protein toxicity.
Horizontal Gene Transfer Constrains the Timing of Methanogen Evolution
Authors: Wolfe Joanna M. , Fournier Gregory P. 
Published: April 2017

ABSTRACTMicrobial methanogenesis may have been a major component of Earth’s carbon cycle during the Archaean Eon, generating a methane greenhouse that increased global temperatures enough for a liquid hydrosphere, despite the sun’s lower luminosity at the time. Evaluation of potential solutions to the “faint young sun” hypothesis by determining the age of microbial methanogenesis was limited by ambiguous geochemical evidence, and the absence of a diagnostic fossil record. To overcome these challenges, we utilize a temporal constraint: a horizontal gene transfer (HGT) event from within archaeal methanogens to the ancestor of Cyanobacteria, one of the few microbial clades with recognized crown group fossils. Results of molecular clock analyses calibrated by this HGT-propagated constraint show methanogens diverging within Euryarchaeota no later than 3.51 Ga, with methanogenesis itself likely evolving earlier. This timing provides independent support for scenarios wherein microbial methane production was important in maintaining temperatures on the early Earth.
Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L1 is enhanced by a mutation that causes multisystem proteinopathy
Authors: Blythe Emily E. , Olson Kristine C. , Chau Vincent , Deshaies Raymond J. 
Published: April 2017

Abstractp97 is a ‘segregase’ that plays a key role in numerous ubiquitin-dependent pathways, such as ER-associated degradation (ERAD). It has been hypothesized that p97 extracts proteins from membranes or macromolecular complexes to enable their proteasomal degradation; however, the complex nature of p97 substrates has made it difficult to directly observe the fundamental basis for this activity. To address this issue, we developed a soluble p97 substrate—Ub-GFP modified with K48-linked ubiquitin chains—for in vitro p97 activity assays. We demonstrate for the first time that wild type p97 can unfold proteins and that this activity is dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branched chains providing maximal stimulation. Furthermore, we show that a p97 mutant that causes inclusion body myopathy, Paget’s Disease of bone, and frontotemporal dementia (IBMPFD) in humans unfolds substrate faster, suggesting that excess activity may underlie pathogenesis. This work overcomes a significant barrier in the study of p97 and will allow the future dissection of p97 mechanism at a level of detail previously unattainable.
Special section: advancing customer experience and big data impact via academic–practitioner collaboration
Authors: Burton Jamie , Nasr Linda , Gruber Thorsten , Bruce Helen L. 
Published: April 2017

PurposeThis paper aims to outline the purpose, planning, development and delivery of the “1st Academic-Practitioner Research with Impact workshop: Customer Experience Management (CEM) and Big Data” held at Alliance Manchester Business School on 18th and 19th January 2016, at which four subsequent papers were initially developed.Design/methodology/approachThe paper sets out a summary of the importance and significance of the four papers developed at the workshop and how the co-creative dialogue between managerial practitioners, presenting key problems and issues that they face, and carefully selected teams of academics was facilitated.FindingsTo develop richer and more impactful understanding of current problems challenging customer-focused managers, there is a need for more dialogue and engagement between academics and practitioners.Practical implicationsThe paper serves as a guideline for developing future workshops that aim at strengthening the links between academia and the business world.Originality/valueThis paper highlights the value of academic–practitioner workshops for focusing academic research on areas of importance for practitioners to generate impact. The innovative format of the workshop and the resulting impactful papers should serve as a call and motivation for future academic–practitioner workshop development.
Alternative measures of satisfaction and word of mouth
Authors: Sivadas Eugene , Jindal Rupinder Paul 
Published: April 2017

Purpose
Scholars have conceptualized and measured customer satisfaction in several different ways such as overall satisfaction and relative satisfaction. This paper aims to study if how one conceptualizes customer satisfaction matters. The authors study if key attributes of customer satisfaction differ in their impact based on how satisfaction is conceptualized. Furthermore, they examine the effects of these alternative measures of satisfaction on word of mouth (WOM).

Design/methodology/approach
The authors conduct three survey studies: at a single independently owned restaurant (n = 248); across restaurants using a national sample of respondents (n = 208); and across apparel retailers using a local sample of respondents (n = 214). The authors analyzed data using iterative seemingly unrelated regression and recursive system of equations with correlated errors.

Findings
The core offering (food quality or merchandise quality) and service influence overall satisfaction about equally; however, influence of the core offering on relative satisfaction is more than that of service. Furthermore, while overall satisfaction influences WOM, relative satisfaction does not. Thus, focusing solely on the core offering to improve relative satisfaction may not be enough. Positive WOM is generated when customers are overall satisfied with the brand which demands both a superior core offering as well as high service. Firms should aim for overall best performance rather than merely better relative performance.

Originality/value
To the best of the authors’ knowledge, this is the first paper to simultaneously study these two alternative measures of customer satisfaction along with their antecedents and influence on WOM.
Emotional intelligence in front-line/back-office employee relationships
Authors: Kearney Treasa , Walsh Gianfranco , Barnett Willy , Gong Taeshik , Schwabe Maria , Ifie Kemefasu 
Published: April 2017

PurposeThis paper aims to undertake a simultaneous assessment of interdependence in the behaviours of front-line and back-office employees and their joint effect on customer-related organisational performance. It also tests for a moderating influence of the emotional intelligence of front-line salespeople and back-office employees.Design/methodology/approachThe sample comprises 105 front-line sales employees and 77 back-office employees. The customer-related organisational performance data come from a UK business-to-business (B2B) electronics company. With these triadic data, this study uses partial least squares to estimate the measurement and structural models.FindingsSalespeople’s customer orientation directly affects customer-related organisational performance; the relationship is moderated by salespeople’s emotional intelligence. The emotional intelligence of salespeople also directly affects the customer-directed citizenship behaviour of back-office employees. Furthermore, the emotional intelligence of back-office staff moderates the link between the emotional intelligence of salespeople and back-office staff citizenship behaviour. Back-office staff citizenship behaviour, in turn, affects customer-related organisational performance.Originality/valueThe emotions deployed by employees in interactions with customers clearly shape customers’ perceptions of service quality, as well as employee-level performance outcomes. However, prior literature lacks insights into the simultaneous effects of front-line and back-office employee behaviour, especially in B2B settings. This paper addresses these research gaps by investigating triadic relationships – among back-office employees, front-line employees and customer outcomes – in a B2B setting, where they are of particular managerial interest.
Does corporate social responsibility matter to financial service representatives in faith-expressive firms?
Authors: Al-Wugayan Adel A.A. 
Published: April 2017

PurposeThis paper aims to investigate the conceptual and empirical effects of corporate social responsibility (CSR) on affective and behavioral inclinations of financial service representatives (FSRs) in faith-expressive (FE) banks and financial institutions in non-Western markets.Design/methodology/approachDrawing upon recent CSR research findings, this study proposed a conceptual model of the association between FSRs’ perceptions of the firm’s CSR toward stakeholders with FSRs’ affective attachment, work engagement and proactive work inclinations using survey data (n= 175). Pre-analysis procedures were applied followed by structural equation modeling to test the hypotheses.FindingsFSRs were more emotionally attached to the firm when CSR initiatives were directed at them or toward social organizations, but were generally ambivalent to CSR directed to suppliers or competition. As firm attachment becomes stronger, propensity to engage in work and proactive work behaviors increases.Research limitations/implicationsThis paper improves management understanding and sensitivity to managing the service salesforce in FE firms as emerging organizations. Future research can focus on actual measures of job performance and on comparative results when applied to traditional financial firms.Practical implicationsMarketing managers relying on CSR to motivate FSRs should realize its limitations when applied to FE firms. Qualitative approaches to solicit stakeholders’ input are encouraged to improve CSR performance.Originality/valueIn non-Western FE firms, strategizing CSR initiative spending should include its potential impact on service employees dealing with customers with particular attention to firm attachment, and inclination to excel in service providing.
Can We Help?: Kids Volunteering to Help Their Communities
Authors: Swain Holly Hilboldt , Chapman Meagan Roberts 
Published: April 2017

Purpose
The purpose of this paper is to allow students to explore the role of volunteerism in their communities as they become community helpers through a service learning project to engage in action within their local areas. This lesson introduces various social studies concepts of civic responsibility while allowing students to think critically and examine their own feelings of empathy and ways to enact these feelings to help others.

Design/methodology/approach
Students create a class service project after they explore the content of the trade book and related resources and teach and learn with one another about helping their communities. Students will expand their learning and apply critical thinking as they note similarities and differences in community helpers’ abilities and their own abilities while they identify themselves as citizens of a community.

Findings
Findings include actively engaged students independently and cooperatively participating in meaningful and relevant learning. The lessons are designed so that they may be differentiated for differing needs of early childhood students and for students with special needs. Further, the lessons encourage an interdisciplinary approach to teaching social studies in the early grades.

Originality/value
The value of this lesson is apparent in the way it allows early childhood students and students with special needs to recognize their own roles as volunteers and agents of change in their communities. This lesson provides ample support for teachers working with early childhood students and students with special needs who may have few experiences with service learning prior to these lessons.
Social justice through citizenship education: a collective responsibility
Authors: Fry Sara Winstead , O’Brien Jason 
Published: April 2017

Purpose
Existing research suggests that preservice elementary teachers tend to believe “good” citizens are people who follow laws and help others rather than people who embrace a more active model of citizenship that includes working to improve society. The purpose of this paper is to propose that this trend results from a self-perpetuating cycle of passive citizenship that develops in part due to state curriculum standards and school experiences which focus on transmitting knowledge rather than preparing students to be active agents of change.

Design/methodology/approach
The paper presents the results of action research conducted in a teacher preparation course; the research was designed to investigate the impact of a systematic effort to see if preservice teachers’ perspectives could be broadened to include a social justice perspective.

Findings
As a result of the findings, the authors argue that to counteract the cycle of passive citizenship, education to create a more socially just world must be a collective responsibility shared by teachers at all levels, K-16.

Originality/value
This is original research that examines an approach to end a cycle of passive citizenship by promoting social justice.