bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the temporal dynamics of suspended sediment during flood events with 7Be and 210Pbxs measurements in a drained lowland catchment
Authors: Le Gall Marion , Evrard Olivier , Foucher Anthony , Laceby J. Patrick , Salvador-Blanes Sébastien , Manière Louis , Lefèvre Irène , Cerdan Olivier , Ayrault Sophie 
Published: February 2017

AbstractSoil erosion is recognized as one of the main processes of land degradation in agricultural areas. High suspended sediment loads, often generated from eroding agricultural landscapes, are known to degrade downstream environments. Accordingly, there is a need to understand soil erosion dynamics during flood events. Suspended sediment was therefore sampled in the river network and at tile drain outlets during five flood events in a lowland drained catchment in France. Source and sediment fallout radionuclide concentrations (7Be, 210Pbxs) were measured to quantify both the fraction of recently eroded particles transported during flood events and their residence time. Results indicate that the mean fraction of recently eroded sediment, estimated for the entire Louroux catchment, increased from 45 ± 20% to 80 ± 20% between December 2013 and February 2014, and from 65 ± 20% to 80 ± 20% in January 2016. These results demonstrate an initial flush of sediment previously accumulated in the river channel before the increasing supply of sediment recently eroded from the hillslopes during subsequent events. This research highlights the utility of coupling continuous river monitoring and fallout radionuclide measurements to increase our understanding of sediment dynamics and improve the management of soil and water resources in agricultural catchments.
Dynamic hub load predicts cognitive decline after resective neurosurgery
Authors: Carbo Ellen W. S. , Hillebrand Arjan , van Dellen Edwin , Tewarie Prejaas , de Witt Hamer Philip C. , Baayen Johannes C. , Klein Martin , Geurts Jeroen J. G. , Reijneveld Jaap C. , Stam Cornelis J. , Douw Linda 
Published: February 2017

AbstractResective neurosurgery carries the risk of postoperative cognitive deterioration. The concept of ‘hub (over)load’, caused by (over)use of the most important brain regions, has been theoretically postulated in relation to symptomatology and neurological disease course, but lacks experimental confirmation. We investigated functional hub load and postsurgical cognitive deterioration in patients undergoing lesion resection. Patients (n = 28) underwent resting-state magnetoencephalography and neuropsychological assessments preoperatively and 1-year after lesion resection. We calculated stationary hub load score (SHub) indicating to what extent brain regions linked different subsystems; high SHub indicates larger processing pressure on hub regions. Dynamic hub load score (DHub) assessed its variability over time; low values, particularly in combination with high SHub values, indicate increased load, because of consistently high usage of hub regions. Hypothetically, increased SHub and decreased DHub relate to hub overload and thus poorer/deteriorating cognition. Between time points, deteriorating verbal memory performance correlated with decreasing upper alpha DHub. Moreover, preoperatively low DHub values accurately predicted declining verbal memory performance. In summary, dynamic hub load relates to cognitive functioning in patients undergoing lesion resection: postoperative cognitive decline can be tracked and even predicted using dynamic hub load, suggesting it may be used as a prognostic marker for tailored treatment planning.
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway
Authors: Liu Jie , Li Juan , Li Pingping , Wang Yaochun , Liang Zheyong , Jiang Yina , Li Jing , Feng Chen , Wang Ruiqi , Chen He , Zhou Can , Zhang Jianmin , Yang Jin , Liu Peijun 
Published: February 2017

AbstractDiscs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that DLG5 is decreased in Yes-associated protein (YAP)-overexpressing cells. However, the exact relationship between DLG5 and YAP is not clear. In this study, we showed that loss of DLG5 promoted breast cancer cell proliferation by inhibiting the Hippo signaling pathway and increasing nuclear YAP expression. Furthermore, depletion of DLG5 induced epithelial-mesenchymal transition (EMT) and disrupted epithelial cell polarity, which was associated with altered expression of Scribble, ZO1, E-cadherin and N-cadherin and their mislocalization. Interestingly, we first reported that loss of DLG5 inhibited the interaction of Mst1 and Lats1 with Scribble, which was crucial for YAP activation and the transcription of TEA domain (TEAD) family members. In summary, loss of DLG5 expression promoted breast cancer malignancy by inactivating the Hippo signaling pathway and increasing nuclear YAP.
Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine photodynamic therapy disrupts redox homeostasis and induce mitochondria-mediated apoptosis in human breast cancer cells
Authors: Saneesh Babu P. S. , Manu Prasad M. , Dhanya T. Jayaram , Tapas Pradhan , Meera R. Nair , Surendran Arun , Aneesh Kumar A. , Vadakkancheril S. Jisha , Ramaiah Danaboyina , Nair S. Asha , Pillai M. Radhakrishna 
Published: February 2017

AbstractPhotodynamic therapy (PDT) is a clinically established and highly evolving treatment modality for cancer. PDT utilizes a light responsive drug called photosensitizer that selectively destroys tumor cells upon light irradiation. Squaraines are a class of dyes possessing all favorable characteristics of a photosensitizer and have been considered to be a potent candidate for next generation PDT. In this study we chose an iodo derivative of squaraine called diiodo-squaraine (bis(3, 5-diiodo-2,4,6-trihydroxyphenyl)squaraine) which has been reported for its tumor specificity but least studied for its cellular and molecular functions. Our studies revealed that the iodo derivative of squaraine possess maximum photodynamic activity in human breast cancer cells MDA- MB- 231 and had very little cytotoxicity in normal breast cells MCF-10A. We analyzed its pro and anti-apoptotic events initiated by oxidative stress exploring a proteomic approach and delineated other critical molecular pathways and key proteins involved in regulating the complex network of cellular response upon PDT. Our study showed that, diiodo- squaraines predominantly accumulate in mitochondria and induce mitochondria-mediated apoptosis. Our study also reveals the novel mechanistic role of diiodo-squaraines to induce oxidative stress there by activating both protective and death inducing pathways post PDT.
Metacarpal Bone Plane Examination by Ultrasonography for the Diagnosis of Fetal Forearm and Hand Deformity
Authors: Zhou Leiping , Lv Mingli , Zeng Min , Zhou Yun , Yang Tian , Yang Yu , Cao Yunyun , Kong Xiaoxiao , Niu Jianmei 
Published: February 2017

AbstractWe explored the value of the metacarpal bone plane in screening for serious fetal forearm and hand deformities, excluding simple polydactyly and dactylion deformity, by ultrasonographic examination. Observed the second to fifth metacarpal bone plane of fetuses in 20,139 pregnant women at a gestational age of 16 to 30 weeks in The International Peace Maternity & Child Health Hospital of China Welfare Institute (IPMCH). There was a total 138 cases of fetal forearm and/or hand deformity among the 20,139 pregnant women. Of these, 134 cases were diagnosed, 4 cases were not diagnosed, and 1 case was misdiagnosed. Among the 134 diagnosed cases, there were 19 cases of hand absence, 5 cases of cleft hand, 13 cases of ectrodactyly, 26 cases of radius absence, 9 cases of forearm and hand dysplasia, 55 cases of thanatophoric dysplasia, 6 cases of wrist joint dysplasia, and 1 case of forearm amputation deformity. The deformity rate was 0.76%, the diagnostic coincidence rate was 99.97%, the sensitivity was 97.10%, the specificity was 99.99%, and the false negative rate was 2.9%. As such, careful observation of the metacarpal bone plane can be used increase the diagnosis rate of fetal forearm and hand deformity.
Physiological and transcriptomic analyses reveal a response mechanism to cold stress in Santalum album L. leaves
Authors: Zhang Xinhua , Teixeira da Silva Jaime A. , Niu Meiyun , Li Mingzhi , He Chunmei , Zhao Jinhui , Zeng Songjun , Duan Jun , Ma Guohua 
Published: February 2017

AbstractSantalum album L. (Indian sandalwood) is an economically important plant species because of its ability to produce highly valued perfume oils. Little is known about the mechanisms by which S. album adapts to low temperatures. In this study, we obtained 100,445,724 raw reads by paired-end sequencing from S. album leaves. Physiological and transcriptomic changes in sandalwood seedlings exposed to 4 °C for 0–48 h were characterized. Cold stress induced the accumulation of malondialdehyde, proline and soluble carbohydrates, and increased the levels of antioxidants. A total of 4,424 differentially expressed genes were responsive to cold, including 3,075 cold-induced and 1,349 cold-repressed genes. When cold stress was prolonged, there was an increase in the expression of cold-responsive genes coding for transporters, responses to stimuli and stress, regulation of defense response, as well as genes related to signal transduction of all phytohormones. Candidate genes in the terpenoid biosynthetic pathway were identified, eight of which were significantly involved in the cold stress response. Gene expression analyses using qRT-PCR showed a peak in the accumulation of SaCBF2 to 4, 50-fold more than control leaves and roots following 12 h and 24 h of cold stress, respectively. The CBF-dependent pathway may play a crucial role in increasing cold tolerance.
Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime
Authors: Lundberg Randi , Bahl Martin I. , Licht Tine R. , Toft Martin F. , Hansen Axel K. 
Published: February 2017

AbstractGerm-free rodents colonized with microbiotas of interest are used for host-microbiota investigations and for testing microbiota-targeted therapeutic candidates. Traditionally, isolators are used for housing such gnotobiotic rodents due to optimal protection from the environment, but research groups focused on the microbiome are increasingly combining or substituting isolator housing with individually ventilated cage (IVC) systems. We compared the effect of housing systems on the gut microbiota composition of germ-free mice colonized with a complex microbiota and housed in either multiple IVC cages in an IVC facility or in multiple open-top cages in an isolator during three generations and five months. No increase in bacterial diversity as assessed by 16S rRNA gene sequencing was observed in the IVC cages, despite not applying completely aseptic cage changes. The donor bacterial community was equally represented in both housing systems. Time-dependent clustering between generations was observed in both systems, but was strongest in the IVC cages. Different relative abundance of a Rikenellaceae genus contributed to separate clustering of the isolator and IVC communities. Our data suggest that complex microbiotas are protected in IVC systems, but challenges related to temporal dynamics should be addressed.
RNA-Seq analysis of nodule development at five different developmental stages of soybean (Glycine max) inoculated with Bradyrhizobium japonicum strain 113-2
Authors: Yuan Song L. , Li Rong , Chen Hai F. , Zhang Chan J. , Chen Li M. , Hao Qing N. , Chen Shui L. , Shan Zhi H. , Yang Zhong L. , Zhang Xiao J. , Qiu De Z. , Zhou Xin A. 
Published: February 2017

AbstractNodule development directly affects nitrogen fixation efficiency during soybean growth. Although abundant genome-based information related to nodule development has been released and some studies have reported the molecular mechanisms that regulate nodule development, information on the way nodule genes operate in nodule development at different developmental stages of soybean is limited. In this report, notably different nodulation phenotypes in soybean roots inoculated with Bradyrhizobium japonicum strain 113-2 at five developmental stages (branching stage, flowering stage, fruiting stage, pod stage and harvest stage) were shown, and the expression of nodule genes at these five stages was assessed quantitatively using RNA-Seq. Ten comparisons were made between these developmental periods, and their differentially expressed genes were analysed. Some important genes were identified, primarily encoding symbiotic nitrogen fixation-related proteins, cysteine proteases, cystatins and cysteine-rich proteins, as well as proteins involving plant-pathogen interactions. There were no significant shifts in the distribution of most GO functional annotation terms and KEGG pathway enrichment terms between these five development stages. A cystatin Glyma18g12240 was firstly identified from our RNA-seq, and was likely to promote nodulation and delay nodule senescence. This study provides molecular material for further investigations into the mechanisms of nitrogen fixation at different soybean developmental stages.
Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans.
Authors: Jauhar S , Veronese M , Rogdaki M , Bloomfield M , Natesan S , Turkheimer F , Kapur S , Howes O D 
Published: February 2017

AbstractDopaminergic function has a key role in normal brain function, dopaminergic dysfunction being implicated in numerous neuropsychiatric disorders. Animal studies show that dopaminergic stimulation regulates dopaminergic function, but it is not known whether this exists in humans. In the first study (study 1), we measured dopamine synthesis capacity (indexed as Kicer) to identify the relationship between baseline and change in Kicer under resting conditions for comparison with effects of dopaminergic stimulation. In the second study (study 2), we used a within-subjects design to test effects of dopaminergic stimulation on dopamine synthesis capacity. In study 1, eight volunteers received two 18F-DOPA scans on separate days, both at rest. In study 2, 12 healthy male volunteers received two 18F-DOPA positron emission tomographic (PET) scans after treatment with either the dopamine partial agonist apomorphine (0.03 or 0.005 mg kg−1) or placebo. In study 1, no significant correlation was found between baseline and change in dopamine synthesis capacity between scans (r=−0.57, n=8, P=0.17, two-tailed). In study 2, a significant negative correlation was found between baseline dopamine synthesis capacity and percentage change in dopamine synthesis capacity after apomorphine challenge (r=−0.71, n=12, P=0.01, two-tailed). This correlation was significantly different (P<0.01) from the correlation between baseline and change in dopamine synthesis capacity under unstimulated conditions. One-way repeated-measures analysis of variance showed a significant group (study 1/study 2) × time interaction (F(1,18)=11.5, P=0.003). Our findings suggest that regulation of dopamine synthesis capacity by apomorphine depends on baseline dopamine function, consistent with dopamine stimulation stabilizing dopaminergic function. Loss of this autoregulation may contribute to dopaminergic dysfunction in brain disorders such as schizophrenia, substance dependence, and Parkinson's disease.
Family of soft‐switching pulse‐width modulation converters using coupled passive snubber
Authors: Esteki Morteza , Mohammadi Mehdi , Yazdani Mohammad Rouhollah , Adib Ehsan , Farzanehfard Hosein 
Published: February 2017

Efficiency, power density and electromagnetic interference (EMI) stand among the main concerns in power electronics and determine the quality of a power converter. To address the aforementioned concerns, this study proposes a cost effective passive soft‐switching technique using coupled inductor for pulse‐width modulation (PWM) converters. Through providing soft‐switching conditions, switching losses are reduced and the use of coupled inductor technique improves the power density. Since, the slope of voltage and current variations over time is reduced by the proposed passive soft‐switching technique, the EMI level is expected to reduce. This technique can be applied to a wide range of PWM converters, however, the analysis is focused on a soft‐switching boost converter to provide a framework. The experimental measurements of the realised 200 W boost converter show that the efficiency is improved by 2 and 3.8% as compared to a hard switching boost converter with and without an RCD snubber circuit, respectively. Moreover, the experimental EMI measurements indicate that with no external EMI filter, the proposed technique has reduced the main peak of EMI level by 8 dBµV (in comparison to its hard switching counterpart) which satisfies CISPR22 class A EMC standard limitation.
GaiaData Release 1
Authors: Arenou F. , Luri X. , Babusiaux C. , Fabricius C. , Helmi A. , Robin A. C. , Vallenari A. , Blanco-Cuaresma S. , Cantat-Gaudin T. , Findeisen K. , Reylé C. , Ruiz-Dern L. , Sordo R. , Turon C. , Walton N. A. , Shih I.-C. , Antiche E. , Barache C. , Barros M. , Breddels M. , Carrasco J. M. , Costigan G. , Diakité S. , Eyer L. , Figueras F. , Galluccio L. , Heu J. , Jordi C. , Krone-Martins A. , Lallement R. , Lambert S. , Leclerc N. , Marrese P. M. , Moitinho A. , Mor R. , Romero-Gómez M. , Sartoretti P. , Soria S. , Soubiran C. , Souchay J. , Veljanoski J. , Ziaeepour H. , Giuffrida G. , Pancino E. , Bragaglia A. 
Published: February 2017

Context.Before the publication of theGaiaCatalogue, the contents of the first data release have undergone multiple dedicated validation tests.Aims.These tests aim to provide in-depth analysis of the Catalogue content in order to detect anomalies and individual problems in specific objects or in overall statistical properties, and either to filter them before the public release or to describe the different caveats on the release for an optimal exploitation of the data.Methods.Dedicated methods using eitherGaiainternal data, external catalogues, or models have been developed for the validation processes. They test normal stars as well as various populations such as open or globular clusters, double stars, variable stars, and quasars. Properties of coverage, accuracy, and precision of the data are provided by the numerous tests presented here and are jointly analysed to assess the data release content.Results.This independent validation confirms the quality of the published data,GaiaDR1 being the most precise all-sky astrometric and photometric catalogue to date. However, several limitations in terms of completeness, and astrometric or photometric quality are identified and described. Figures describing the relevant properties of the release are shown, and the testing activities carried out validating the user interfaces are also described. A particular emphasis is made on the statistical use of the data in scientific exploitation.
An in-depth spectroscopic examination of molecular bands from 3D hydrodynamical model atmospheres
Authors: Gallagher A. J. , Caffau E. , Bonifacio P. , Ludwig H.-G. , Steffen M. , Homeier D. , Plez B. 
Published: February 2017

Context. Tighter constraints on metal-poor stars we observe are needed to better understand the chemical processes of the early Universe. Computing a stellar spectrum in 3D allows one to model complex stellar behaviours, which cannot be replicated in 1D.
Aims. We examine the effect that the intrinsic CNO abundances have on a 3D model structure and the resulting 3D spectrum synthesis.
Methods. Model atmospheres were computed in 3D for three distinct CNO chemical compositions using the CO5BOLD model atmosphere code, and their internal structures were examined. Synthetic spectra were computed from these models using Linfor3D and they were compared. New 3D abundance corrections for the G-band and a selection of UV OH lines were also computed.
Results. The varying CNO abundances change the metal content of the 3D models. This had an effect on the model structure and the resulting synthesis. However, it was found that the C/O ratio had a larger effect than the overall metal content of a model.
Conclusions. Our results suggest that varying the C/O ratio has a substantial impact on the internal structure of the 3D model, even in the hot turn-off star models explored here. This suggests that bespoke 3D models, for specific CNO abundances should be sought. Such effects are not seen in 1D at these temperature regimes.
Fulminant Influenza B Myocarditis in a Pediatric Patient
Authors: Censoplano Nina , Schumacher Kurt , McCormick Amanda 
Published: February 2017

AbstractInfluenza B is a common viral illness in childhood. We report a 5-year-old previously healthy girl admitted with facial edema that developed severe acute myocarditis from influenza B infection. As her clinical course progressed, she ultimately developed severe, acute heart failure requiring extracorporeal membrane oxygenation for support.
Female sociality and sexual conflict shape offspring survival in a Neotropical primate
Authors: Kalbitzer Urs , Bergstrom Mackenzie L. , Carnegie Sarah D. , Wikberg Eva C. , Kawamura Shoji , Campos Fernando A. , Jack Katharine M. , Fedigan Linda M. 
Published: February 2017

Significance
In group-living mammals, infants of females with strong social relationships sometimes exhibit higher survivorship than infants of less social females, a finding that holds true in our study population of wild white-faced capuchin monkeys. However, as in many mammals, new alpha male capuchins often kill young infants sired by other males. Our long-term research shows that infants of highly social females are at greater risk of dying or disappearing during periods of alpha male replacements than infants of less social females. These findings indicate that new alpha males are more likely to target the infants of more social, and therefore central, females. Our study provides evidence that female sociality can negatively affect offspring survival by increasing the likelihood of infanticide.
Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant
Authors: Dembinski Holly E. , Wismer Kevin , Vargas Jesse D. , Suryawanshi Gajendra W. , Kern Nadja , Kroon Gerard , Dyson H. Jane , Hoffmann Alexander , Komives Elizabeth A. 
Published: February 2017

Significance
Stress-response transcription factors turn on hundreds of genes, and their activity must be turned off completely and quickly. The inhibitor protein IκBα turns off NFκB by forming a transient ternary complex with the NFκB–DNA complex and then promoting DNA dissociation (molecular stripping). Here we report a mutant IκBα that is impaired in its ability to strip NFκB from DNA. The mutant forms a more stable ternary complex, and biophysical characterization shows what IκBα looks like “in the act of stripping.” We also show in single-cell nuclear export assays that the decrease in the rate of DNA dissociation from the mutant ternary complex matches the decrease in the rate of nuclear NFκB export in cells.
A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes
Authors: Zhang Hong , Gregorio Josh D. , Iwahori Toru , Zhang Xiangyue , Choi Okmi , Tolentino Lorna L. , Prestwood Tyler , Carmi Yaron , Engleman Edgar G. 
Published: February 2017

Significance
Plasmacytoid dendritic cells (pDCs) are specialized white blood cells responsible for a wide range of immune functions, most notably production of the antiviral factor, type I interferon. We have discovered a previously unknown population of pDCs in human blood, bone marrow, and tonsil that is morphologically, phenotypically, and genetically distinct from most pDCs. These cells, which can be identified based on their expression of CD2, CD5, and CD81 on their surface, fail to produce type I interferon, yet they strongly activate B and T lymphocytes. A functionally and phenotypically similar population of pDCs is present in mice. These pDCs likely play an important role in the immune response.