bluuebunny/crossref_metadata_2025_split huggingface dataset:
The American Society of Colon and Rectal Surgeons Assessment Tool for Performance of Laparoscopic Colectomy
Authors: Champagne Bradley J. , Steele Scott R. , Hendren Samantha K. , Bakaki Paul M. , Roberts Patricia L. , Delaney Conor P. , Brady Justin T. , MacRae Helen M. 
Published: June 2017

BACKGROUND:
The lack of consensus for performance assessment of laparoscopic colorectal resection is a major impediment to quality improvement.

OBJECTIVE:
The purpose of this study was to develop and assess the validity of an evaluation tool for laparoscopic colectomy that is feasible for wide implementation.

DESIGN:
During the pilot phase, a small group of experts modified previous assessment tools by watching videos for laparoscopic right colectomy with the following categories of experience: novice (less than 20 cases), intermediate (50–100 cases), and expert (more than 500 cases). After achieving sufficient reliability (κ > 0.8), a user-friendly tool was validated among a large group of blinded, trained experts.

SETTING:
The study was conducted through the American Society of Colon and Rectal Surgeons Operative Competency Evaluation Committee.

PATIENTS:
Raters were from the Operative Competency Evaluation Committee of the American Society of Colon and Rectal Surgeons.

MAIN OUTCOME MEASURES:
Assessment tool reliability and internal consistency were measured.

RESULTS:
From October 2014 through February 2015, 4 groups of 5 raters blinded to surgeon skill level evaluated 6 different laparoscopic right colectomy videos (novice = 2, intermediate = 2, expert = 2). The overall Cronbach α was 0.98 (>0.9 = excellent internal consistency). The intraclass correlation for the overall assessment was 0.93 (range, 0.77–0.93) and was >0.74 (excellent) for each step. The average scores (scale, 1–5) for experts were significantly better than those in the intermediate category, with a mean (SD) of 4.51 (0.56) versus 2.94 (0.56; p = 0.003). Videos in the intermediate group scored more favorably than beginner videos for each individual step and overall performance (mean (SD) = 3.00 (0.32) vs 1.78 (0.42); p = 0.006).

LIMITATIONS:
The study was limited by rater bias to technique and style.

CONCLUSIONS:
The unique and robust methodology in this trial produced an assessment tool that was feasible for raters to use when assessing videotaped laparoscopic right hemicolectomies. The potential applications for this new tool are widespread, including both training and evaluation of competence at the attending level. See Video Abstract at http://links.lww.com/DCR/A369, http://links.lww.com/DCR/A370, http://links.lww.com/DCR/A371.
The minimally invasive approach to the symptomatic isthmocele – what does the literature say? A step-by-step primer on laparoscopic isthmocele – excision and repair
Authors: Sipahi Sevgi , Sasaki Kirsten , Miller Charles E. 
Published: June 2017

Purpose of review
The purpose of this review is to understand the minimally invasive approach to the excision and repair of an isthmocele.

Recent findings
Previous small trials and case reports have shown that the minimally invasive approach by hysteroscopy and/or laparoscopy can cure symptoms of a uterine isthmocele, including abnormal bleeding, pelvic pain and secondary infertility. A recent larger prospective study has been published that evaluates outcomes of minimally invasive isthmocele repair. Smaller studies and individual case reports echo the positive results of this larger trial.

Summary
The cesarean section scar defect, also known as an isthmocele, has become an important diagnosis for women who present with abnormal uterine bleeding, pelvic pain and secondary infertility. It is important for providers to be aware of the effective surgical treatment options for the symptomatic isthmocele. A minimally invasive approach, whether it be laparoscopic or hysteroscopic, has proven to be a safe and effective option in reducing symptoms and improving fertility.

Video abstract

http://links.lww.com/COOG/A37.
Revealing the hidden structure of dynamic ecological networks
Authors: Miele Vincent , Matias Catherine 
Published: June 2017

In ecology, recent technological advances and long-term data studies now provide longitudinal interaction data (e.g. between individuals or species). Most often, time is the parameter along which interactions evolve but any other one-dimensional gradient (temperature, altitude, depth, humidity, etc.) can be considered. These data can be modelled through a sequence of different snapshots of an evolving ecological network, i.e. a dynamic network. Here, we present how the dynamic stochastic block model approach developed by Matias & Miele (Matias & Miele In pressJ. R. Stat. Soc. B(doi:10.1111/rssb.12200)) can capture the complexity and dynamics of these networks. First, we analyse a dynamic contact network of ants and we observe a clear high-level assembly with some variations in time at the individual level. Second, we explore the structure of a food web evolving during a year and we detect a stable predator–prey organization but also seasonal differences in the prey assemblage. Our approach, based on a rigorous statistical method implemented in the R packagedynsbm, can pave the way for exploration of evolving ecological networks.
Post-Transcriptional Control of Coenzyme Q Biosynthesis Revealed by Transomic Analysis of the RNA-Binding Protein Puf3p
Authors: Lapointe Christopher P. , Stefely Jonathan A. , Jochem Adam , Hutchins Paul D. , Wilson Gary M. , Kwiecien Nicholas W. , Coon Joshua J. , Wickens Marvin , Pagliarini David J. 
Published: June 2017

SUMMARYCoenzyme Q (CoQ) is a redox active lipid required for mitochondrial oxidative phosphorylation (OxPhos). How CoQ biosynthesis is coordinated with the biogenesis of OxPhos protein complexes is unclear. Here, we show that theSaccharomyces cerevisiaeRNA-binding protein (RBP) Puf3p directly regulates CoQ biosynthesis. To establish the mechanism for this regulation, we employed a transomic strategy to identify mRNAs that not only bind Puf3p, but also are regulated by Puf3pin vivo. The CoQ biosynthesis enzyme Coq5p is a critical Put3p target: Puf3p regulates the level of Coq5p and prevents its toxicity, thereby enabling efficient CoQ production. In parallel, Puf3p represses a specific set of proteins involved in mitochondrial protein import, translation, and OxPhos complex assembly — pathways essential to prime mitochondrial biogenesis. Our data reveal a mechanism for post-transcriptionally coordinating CoQ production with OxPhos biogenesis and, more broadly, demonstrate the power of transomics for defining genuine targets of RBPs.HIGHLIGHTSThe RNA binding protein (RBP) Puf3p regulates coenzyme Q (CoQ) biosynthesisTransomic analysis of RNAs, proteins, lipids, and metabolites defines RBP targetsPuf3p regulates the potentially toxic CoQ biosynthesis enzyme Coq5pPuf3p couples regulation of CoQ with a broader program for controlling mitochondria
FGF21 regulates melanogenesis in alpaca melanocytesviaERK1/2-Mediated MITF downregulation
Authors: Wang Ruiwei , Chen Tianzhi , Zhao Bingling , Fan Ruiwen , Ji Kaiyuan , Yu Xiuju , Wang Xianjun , Dong Changsheng 
Published: June 2017

AbstractFibroblast growth factor 21 (FGF21) is known as a metabolic regulator to regulate the metabolism of glucose and lipids. However, the underlying mechanism of FGF21 on melanin synthesis remains unknown. Therefore, the current study investigates the effect of FGF21 on melanogenesis in alpaca melanocytes. We transfected the FGF21 into alpaca melanocytes, then detected the melanin contents, protein and mRNA levels of pigmentation-related genes in order to determine the melanogenesis-regulating pathway of FGF21. The results showed that FGF21 overexpression suppressed melanogenesis and decreased the expression of the major target genes termedmicrophthalmia-associated transcription factor(MITF) and its downstream genes, including tyrosinase (TYR) and tyrosinase-related protein 2 (TRP2). However FGF21 increased the expression of phospho-extracellular signal-regulated kinase (p-Erk1/2). In contrast, FGF21-siRNA, a small interference RNA mediating FGF21 silencing, abolished the inhibition of melanogenesis. Altogether, FGF21 may decrease melanogenesis in alpaca melanocytes via ERK activation and subsequent MITF downregulation, which is then followed by the suppression of melanogenic enzymes and melanin production.
Brain-derived neurotrophic factor derived from peripheral sensory neurons plays a critical role in pain chronification
Authors: Sikandar Shafaq , Minett Michael S. , Lau Joanne , Millet Queensta , Santana-Varela Sonia , Wood John N , Zhao Jing 
Published: June 2017

AbstractMultiple studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in pain processes in the peripheral and central nervous system. We have previously shown that nociceptor-derived BDNF is implicated in inflammatory pain. Microglial-derived BDNF has also been shown to be involved in neuropathic pain. However, the distinct contribution of primary afferent-derived BNDF to chronic pain processing remains undetermined. In this study, we used Advillin-CreERT2 mice to deleteBdnffrom all adult peripheral sensory neurons. Conditional BDNF knockouts were healthy with no sensory neuron loss. Behavioural assays andin vivoelectrophysiology indicated that spinal excitability was normal. Following formalin inflammation or neuropathy with a modified Chung model, we observed normal development of acute pain behaviour, but a deficit in second phase formalin-induced nocifensive responses and a reversal of neuropathy-induced mechanical hypersensitivity during the later chronic pain phase in conditional BDNF knockout mice. In contrast, we observed normal development of acute and chronic neuropathic pain in the Seltzer model, indicating differences in the contribution of BDNF to distinct models of neuropathy. We further used a model of hyperalgesic priming to examine the contribution of primary afferent-derived BDNF in the transition from acute to chronic pain, and found that primed BDNF knockout mice do not develop prolonged mechanical hypersensitivity. Our data suggest that BDNF derived from sensory neurons plays a critical role in mediating the transition from acute to chronic pain.
A century of guayule: Comprehensive Genetic Characterization of the Guayule (Parthenium argentatumA. Gray) USDA Germplasm Collection
Authors: Ilut Daniel C. , Sanchez Paul L. , Coffelt Terry A. , Dyer John M. , Jenks Matthew A. , Gore Michael A. 
Published: June 2017

AbstractThe fragility of a single-source, geographically concentrated supply of natural rubber, a critical material of the modern economy, has brought guayule (Parthenium argentatumA. Gray) to the forefront as an alternative source of natural rubber. The improvement of guayule for commercial-scale production has been limited by the lack of genomic tools and well-characterized genetic resources required for genomics-assisted breeding. To address this issue, we developed nearly 50,000 single nucleotide polymorphism (SNP) genetic markers and genotyped 69 accessions of guayule and its sister taxa mariola (Parthenium incanumKunth), representing the entire available NALPGRU germplasm collection. We identified multiple interspecific hybrid accessions previously considered guayule, including six guayule-mariola hybrids and non-mariola interspecific hybrid accessions AZ-2 and AZ-3, two commonly used high-yielding cultivars. We dissected genetic diversity within the collection to identify a highly diverse subset of guayule accessions, and showed that wild guayule stands in Big Bend National Park, Texas, USA have the potential to provide hitherto untapped guayule genetic diversity. Together, these results provide the most thorough genetic characterization of guayule germplasm to date and lay the foundation for rapid genetic improvement of commercial guayule germplasm.Key ResultsSix guayule accessions are guayule-mariola hybridsGuayule collections from Big Bend National Park contain novel guayule genotypes not present in collections from MexicoCommonly cultivated accessions AZ2 and AZ3 contain introgressions from otherPartheniumspeciesThe triploid accessions 11591, 11646, N576, N565, N565II, and RICHARDSON are generally indistinguishable from each other with respect to genetic background and likely represent the 4265-I source genotype (Johnson, 1950)Open pollinated and purposefully outcrossed tetraploid selections derived from 4265-I incorporate further genetic diversity and form distinct genotypes
Cortical Entropy Values Correlate with Brain Scale-Free Dynamics
Authors: Tozzi Arturo , Peters James F. , Çankaya Mehmet Niyazi 
Published: June 2017

ABSTRACTA two-dimensional shadow may encompass more information than its corresponding three-dimensional object. If we rotate the object, we achieve a pool of observed shadows from different angulations, gradients, shapes and variable length contours that make it possible for us to increase our available information. Starting from this simple observation, we show how informational entropies might turn out to be useful in the evaluation of scale-free dynamics in the brain. Indeed, brain activity exhibits a scale-free distribution, which appears as a straight line when plotted in a log power versus log frequency plot. A variation in the scale-free exponent and in the line scaling slope may occur during different functional neurophysiological states. Here we show that modifications in scaling slope are associated with variations in Rényi entropy, a generalization of Shannon informational entropy. From a three-dimensional object’s perspective, by changing its orientation (standing for the cortical scale-free exponent), we detect different two-dimensional shadows from different perception angles (standing for Rènyi entropy in different brain areas). We perform simulations showing how, starting from known values of Rènyi entropy (easily detectable in brain fMRIs or EEG traces), it is feasible to calculate the scaling slope in a given moment and a given brain area. Because changes in scale-free cortical dynamics modify brain activity, suggests the possibility of novel insights in mind reading and description of the forces required for transcranial stimulation.
Bitter taste: an agency agreement in Vietnam goes awry
Authors: Hans Wafler Beat , Beise-Zee Rian 
Published: June 2017

Subject area
The case authentically illustrates a common problem encountered within the business scope of an agent who is representing a European food ingredients manufacturer in an emerging market. The case describes the kind of legal set-up and contracts that are necessary to safeguard the long-term prospective of the business for both parties, the agent and overseas supplier. It explains what each party has to observe in case of a termination of the agency agreement.

Study level/applicability
This is a longitudinal case study of a market entry by a European food ingredients manufacturer through a foreign-owned third agent. The authors studied how sales developed over the first few years and then concentrated the investigation on the fact that after the sales volume was reached, the overseas manufacturer wants to cancel the agency agreement and do the business directly without getting the agent involved.

Case overview
This case describes and explains a common problem encountered frequently by overseas manufacturers who want to enter an emerging market through a third-party agent representation. The overseas supplier uses the agent’s service and solid reputation to enter an emerging market with limited exposure to costs and risk. The agent works towards guarding the relationship with the overseas supplier for as long as possible. The development of the relationship illustrates what kind of conditions have to be stipulated in advance to provide an acceptable solution to both parties concerned once they part ways.

Expected learning outcomes
This research is based on a European food ingredients manufacturer, who was expanding its business in different Asian emerging markets, namely, Vietnam and Cambodia. The agent was a long-time established trading house who acted frequently as agent for overseas companies that wanted to get a foothold in these promising Asian emerging markets.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 5: International Business
Do auditor and CFO gender matter to earnings quality? Evidence from Sweden
Authors: Nasution Damai , Jonnergård Karin 
Published: June 2017

PurposeThis study aims to examine the association between auditor and chief financial officer (CFO) gender and earnings quality, utilising data from Sweden. This study also aims to examine whether interactions between auditor and CFO, which may affect a firm’s earnings quality, are associated with their gender. These aims are inspired by the notion that gender differences will be overruled by the rewards and socialisation into the occupational roles as suggested by the structural approach to gender.Design/methodology/approachThis study uses a multivariate regression model to test its hypotheses. The sample consists of 976 firm-year observations covering the period 2008 to 2013.FindingsThe results show that gender of the auditor and CFO is not associated with earnings quality, and the interactions between auditors and CFOs, which may affect earnings quality, are not associated with their gender. Consequently, the results give tentative support for the structural approach in gender studies in the accounting and auditing field.Research limitations/implicationsThis study indicates that future research in gender studies should consider the structural approach based on the argument of gender similarities. This approach contends that work-related behaviour of women will more resemble men, and this is caused by the socialisation process into the occupational role and the structure where they work (e.g. organisational and professional culture, work conditions, a compensation scheme, national culture, etc.) instead of gender.Originality/valueThis study contributes to the understanding whether gender – auditor and CFO gender – is associated with firms’ earnings quality and standing whether the interactions between auditor and CFO are associated with their gender, something that, to the best of the authors’ knowledge, has not been tested previously. It also re-introduces the structural approach within the gender research in the accounting and auditing field.
Environment is free; but it’s not a gift
Authors: Zokaei Keivan , Manikas Ioannis , Lovins Hunter 
Published: June 2017

PurposeThis paperaims to review how the field of lean and green has been evolving. Authors draw parallels between the fields of sustainability and quality management. The paper’s title is borrowed and modified from Crosby’s seminal book: Quality is Free.Design/methodology/approachThe paper starts with a review on how early lean researchers in the late 1980s draw upon benchmark studies, looking at Toyota versus other auto manufacturers to demonstrate that quality is free. Similarly, the authors carry out a benchmark to show how the same argument is valid about Toyota’s environmental performance and how Toyota’s concept of Monozukuri can be exploited as proof for the environment is free movement. The paper concludes with an attempt to address the gap between theory and practice in the field of lean and green.FindingsThe starting point for creating a lean and green business system is the understanding that there is no trade-off between lean and green, that lean and green should be brought together in a symbiosis, as Toyota have done with Monozukuri approach. This requires a coherent strategy that is well developed, and well deployed across all levels of business. The bottom line remains that environment is free, but it is not a gift.Research limitations/implicationsThe findings presented in the paper are based on arguments resulted from the review of the relevant literature. It is important to obtain feedback from a large sample of businesses regarding lean and green symbiosis to arrive at sound and valid conclusions.Originality/valueThis paper contributes to the fields of operations management and sustainability by proposing a change in businesses’ mind-set about sustainability. Rather than seeing environmental protection as a cost, it should be regarded as an opportunity for enhancing economic performance. In doing so, we can seek inspiration from the fields of quality management and the total quality movement.
Quality attributes of Jericoacoara, Brazil
Authors: Anjos Sara Joana Gadotti dos , Meira Jéssica Vieira de Souza , Pereira Melise de Lima , Limberger Pablo Flôres 
Published: June 2017

PurposeSome recent research studies in tourism have focused on the quality of the destination. The purpose of this paper is to identify and test the quality attributes of the destination of Jericoacoara, Brazil, in order to contribute to theoretical and empirical knowledge of the subject.Design/methodology/approachThis study is exploratory and descriptive in nature, with a quantitative approach, and uses questionnaires administered to 391 tourists in Jericoacoara. Data were analyzed through exploratory factor analysis and confirmatory factor analysis.FindingsResults showed that the most important factor in assessing the quality of the destination is service, followed by the factors accommodation, management, destination, and, lastly, attractions.Originality/valueThis study is a theoretical and empirical contribution to the debate on destiny quality and a management tool for strategic planning.
A framework to identify knowledge actor roles in enterprise social networks
Authors: Hacker Janine Viol , Bodendorf Freimut , Lorenz Pascal 
Published: June 2017

Purpose
Enterprise social networks (ESN) are increasingly used by companies to reinforce collaboration and knowledge sharing. While prior research has investigated ESN use practices, little is known about potential user roles emerging on these platforms. Against this backdrop, this paper develops an ESN knowledge actor role framework.

Design/methodology/approach
The framework is constructed based on a systematic review of literature covering knowledge worker role typologies, user roles identified in public online social spaces as well as findings from ESN research.

Findings
The ESN knowledge actor role framework distinguishes eight contributing and two reading roles. It describes the associated participation behaviours and establishes metrics to identify the roles.

Research limitations/implications
Providing a notion of knowledge management-related roles in ESN, the framework enables a better understanding of knowledge processes and the involved actors. Moreover, the paper advances the field of ESN data analytics by designing a set of ESN metrics to characterise user behaviour.

Practical implications
Understanding ESN user roles, in particular regarding their knowledge contributions to the platform, can improve knowledge transparency in companies. The framework may usefully support the identification and management of critical knowledge resources and support decision-making in the areas of human resources management and knowledge management.

Originality/value
Providing a platform for knowledge-intensive interactions as well as record of user activities, ESN are well suited to observe and identify knowledge actor roles emerging in this context.