bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of intensity modulated radiation therapy in treating thyroid-associated ophthalmopathy and predictive factors for treatment response
Authors: Li Yong-Jiang , Luo Yong , Xie Xiao-Qi , He Wei-Min , Yi Cheng , Li Ping , Wang Feng 
Published: December 2017

AbstractThe study evaluated clinical efficacy of intensity modulated radiation therapy (IMRT) in treating patients with thyroid-associated ophthalmopathy (TAO) and defined predictive factors that associated with treatment response. A total of 178 TAO patients were treated with retro-orbital IMRT with radiation dose of 20 Gy in 10 fractions. The immediate and long-term treatment response and complications were evaluated. Besides, logistic-regression analysis was conducted to identify possible predictive factors. TAO symptom score significantly fell from the initiation to 6-month post-treatment (P < 0.001). 134 patients (73.2%) had mild to significant response to IMRT, and 172 patients (96.6%) achieved stabilization of TAO without future progression. Current smoker (OR 2.88, 95% CI 1.32–6.29; P = 0.008) and symptom duration longer than 18 months (OR 3.33, 95% CI 1.24–8.93; P = 0.017) were identified as independent predictive factors for non-response of TAO to retro-orbital IMRT. Immediate complications were slight and self-limited, and long-term complications mainly included chronic xerophthalmias in12 patients (6.74%) and cataract formation in 4 patients (2.25%). The study suggested that IMRT was a viable option for treating TAO patients, with a satisfactory symptom control ability and acceptable post-treatment complications.
Infrared actuation-induced simultaneous reconfiguration of surface color and morphology for soft robotics
Authors: Banisadr Seyedali , Chen Jian 
Published: December 2017

AbstractCephalopods, such as cuttlefish, demonstrate remarkable adaptability to the coloration and texture of their surroundings by modulating their skin color and surface morphology simultaneously, for the purpose of adaptive camouflage and signal communication. Inspired by this unique feature of cuttlefish skins, we present a general approach to remote-controlled, smart films that undergo simultaneous changes of surface color and morphology upon infrared (IR) actuation. The smart film has a reconfigurable laminated structure that comprises an IR-responsive nanocomposite actuator layer and a mechanochromic elastomeric photonic crystal layer. Upon global or localized IR irradiation, the actuator layer exhibits fast, large, and reversible strain in the irradiated region, which causes a synergistically coupled change in the shape of the laminated film and color of the mechanochromic elastomeric photonic crystal layer in the same region. Bending and twisting deformations can be created under IR irradiation, through modulating the strain direction in the actuator layer of the laminated film. Furthermore, the laminated film has been used in a remote-controlled inchworm walker that can directly couple a color-changing skin with the robotic movements. Such remote-controlled, smart films may open up new application possibilities in soft robotics and wearable devices.
One-plasmid double-expression His-tag system for rapid production and easy purification of MS2 phage-like particles
Authors: Mikel Pavel , Vasickova Petra , Kralik Petr 
Published: December 2017

AbstractMS2 phage-like particles (MS2 PLP) are artificially constructed pseudo-viral particles derived from bacteriophage MS2. They are able to carry a specific single stranded RNA (ssRNA) sequence of choice inside their capsid, thus protecting it against the effects of ubiquitous nucleases. Such particles are able to mimic ssRNA viruses and, thus, may serve as the process control for molecular detection and quantification of such agents in several kinds of matrices, vaccines and vaccine candidates, drug delivery systems, and systems for the display of immunologically active peptides or nanomachines. Currently, there are several different in vivo plasmid-driven packaging systems for production of MS2 PLP. In order to combine all the advantages of the available systems and to upgrade and simplify the production and purification of MS2 PLP, a one-plasmid double-expression His-tag system was designed. The described system utilizes a unique fusion insertional mutation enabling purification of particles using His-tag affinity. Using this new production system, highly pure MS2 PLP can be quickly produced and purified by a fast performance liquid chromatography (FPLC) approach. The system can be easily adapted to produce other MS2 PLP with different properties.
Audiological Assessment of Word Recognition Skills in Persons With Aphasia
Authors: Zhang Min , Pratt Sheila R. , Doyle Patrick J. , McNeil Malcolm R. , Durrant John D. , Roxberg Jillyn , Ortmann Amanda 
Published: December 2017

PurposeThe purpose of this study was to evaluate the ability of persons with aphasia, with and without hearing loss, to complete a commonly used open-set word recognition test that requires a verbal response. Furthermore, phonotactic probabilities and neighborhood densities of word recognition errors were assessed to explore potential underlying linguistic complexities that might differentially influence performance among groups.MethodFour groups of adult participants were tested: participants with no brain injury with normal hearing, participants with no brain injury with hearing loss, participants with brain injury with aphasia and normal hearing, and participants with brain injury with aphasia and hearing loss. The Northwestern University Auditory Test No. 6 (NU-6; Tillman & Carhart, 1966) was administered. Those participants who were unable to respond orally (repeating words as heard) were assessed with the Picture Identification Task (Wilson & Antablin, 1980), permitting a picture-pointing response instead. Error patterns from the NU-6 were assessed to determine whether phonotactic probability influenced performance.ResultsAll participants with no brain injury and 72.7% of the participants with aphasia (24 out of 33) completed the NU-6. Furthermore, all participants who were unable to complete the NU-6 were able to complete the Picture Identification Task. There were significant group differences on NU-6 performance. The 2 groups with normal hearing had significantly higher scores than the 2 groups with hearing loss, but the 2 groups with normal hearing and the 2 groups with hearing loss did not differ from one another, implying that their performance was largely determined by hearing loss rather than by brain injury or aphasia. The neighborhood density, but not phonotactic probabilities, of the participants' errors differed across groups with and without aphasia.ConclusionsBecause the vast majority of the participants with aphasia examined could be tested readily using an instrument such as the NU-6, clinicians should not be reticent to use this test if patients are able to repeat single words, but routine use of alternative tests is encouraged for populations of people with brain injuries.
Word Processing in Children With Autism Spectrum Disorders: Evidence From Event-Related Potentials
Authors: Sandbank Micheal , Yoder Paul , Key Alexandra P. 
Published: December 2017

Purpose
This investigation was conducted to determine whether young children with autism spectrum disorders exhibited a canonical neural response to word stimuli and whether putative event-related potential (ERP) measures of word processing were correlated with a concurrent measure of receptive language. Additional exploratory analyses were used to examine whether the magnitude of the association between ERP measures of word processing and receptive language varied as a function of the number of word stimuli the participants reportedly understood.

Method
Auditory ERPs were recorded in response to spoken words and nonwords presented with equal probability in 34 children aged 2–5 years with a diagnosis of autism spectrum disorder who were in the early stages of language acquisition. Average amplitudes and amplitude differences between word and nonword stimuli within 200–500 ms were examined at left temporal (T3) and parietal (P3) electrode clusters. Receptive vocabulary size and the number of experimental stimuli understood were concurrently measured using the MacArthur–Bates Communicative Development Inventories.

Results
Across the entire participant group, word–nonword amplitude differences were diminished. The average word–nonword amplitude difference at T3 was related to receptive vocabulary only if 5 or more word stimuli were understood.

Conclusions
If ERPs are to ever have clinical utility, their construct validity must be established by investigations that confirm their associations with predictably related constructs. These results contribute to accruing evidence, suggesting that a valid measure of auditory word processing can be derived from the left temporal response to words and nonwords. In addition, this measure can be useful even for participants who do not reportedly understand all of the words presented as experimental stimuli, though it will be important for researchers to track familiarity with word stimuli in future investigations.

Supplemental Material

https://doi.org/10.23641/asha.5614840
Transpalatine Route for the Correction of Transsphenoidal Encephalocele in a Child: A Case Report and Literature Review
Authors: Silva Aldo , Lopes Fabrício 
Published: December 2017

Introduction Transsphenoidal encephalocele is a rare neural tube defect characterized by the herniation of meninges and eventually of parts of the brain through a bony defect in the sphenoid bone. The clinical presentation is variable, and surgical treatment is controversial.
Case Report This report describes the case of an 8-month-old female child diagnosed with transsphenoidal encephalocele. The child presented with obstruction of the upper airways and was fed via a nasogastric tube but did not present changes in the hypothalamic-pituitary-axis. The patient underwent surgery with the transsphenoidal–transpalatine route, with an excellent outcome and without fistulas or infections.
Conclusions Although transsphenoidal encephalocele is a rare congenital anomaly, the transsphenoidal–transpalatine route for the correction of this type of encephalocele is a safe option and produces a favorable outcome in pediatric patients.
The Middle Turbinate Resection and Its Repercussion in Olfaction with the University of Pennsylvania Smell Identification Test (UPSIT)
Authors: Mariano Fernando , Hamerschmidt Rogerio , Soares Caio , Moreira Ana 
Published: December 2017

Introduction Nasal obstruction is a common complaint, and, for some, the middle turbinate resection is still a controversial issue among the surgical options due to the possibility of deleterious effects on olfaction. The University of Pennsylvania smell identification test (UPSIT) is considered the gold standard of smell identification tests, but data about it is still incipient in Brazil.
Objective To evaluate if the middle turbinectomy has any repercussion on the sense of olfaction by using the UPSIT as an assessment tool.
Methods A prospective study performed between 2013 and 2015 with 27 patients who were treated with middle turbinectomy by the same surgeon and tested with the UPSIT pre- and post-surgery, with a minimum interval of 3 months.
Results Twenty-five patients completed the study. The mean age was 27.9 years. There was no statistical correlation between middle turbinectomy and the UPSIT score, or between gender and the UPSIT score.
Conclusion There was no clinical repercussion on olfaction from partial middle turbinectomy.
No Association of Genetic Markers with Carotid Intimal Medial Thickness in β-Thalassemia Major Patients
Authors: Singh Mable , Kumar Ravindra , Tewari Satyendra , Agarwal Sarita 
Published: December 2017

AbstractRegular transfusion leads to cardiac siderosis resulting in cardiac complications that account for more than 71% of the total mortality in thalassemia patients. We aimed to study the variants of matrix metalloproteinase-9 (MMP9), matrix Gla protein (MGP), and estrogen receptor α(ERα), which might be contributing to atherosclerosis, leading to heart failure in thalassemia major. One hundred and five thalassemia patients on regular transfusion and iron chelation therapy were enrolled for the study. Carotid artery intimal medial thickness (CIMT) measurement was done to check for atherosclerosis. MMP9 (C1562T), MGP (T138C), and ERα gene (PvuII (rs2234693T > C) and XbaI (rs9340799A > G) polymorphism were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. CIMT values were within the normal range (<0.90 mm) in all patients. There was no difference in mean CIMT values between males and females (0.56 ± 0.11 versus 0.56 ± 0.12, p = 0.928). There was no correlation of CIMT with age, body surface area, and body mass index as well as with serum ferritin levels. No statistically significant difference in frequency of MMP9, MGP, and ERα genotypes was seen in two dichotomized groups of CIMT (CIMT < 0.56 and CIMT ≥ 0.56). Variants of MMP9, MGP, and ERα have a reserved influence on cardiac disease pathogenesis, and the disease phenotype in thalassemia patients may be more strongly impacted by other factors.
Conservative Management after Intraoperative Over-Release of the Medial Collateral Ligament from its Tibial Insertion Site in Patients Undergoing Total Knee Arthroplasty
Authors: Choi Young Joon , Lee Ki Won , Seo Dong Kyo , Lee Suk Kyu , Kim Sang Bum , Lee Hyun Il 
Published: December 2017

AbstractDuring varus deformity correction in a patient undergoing total knee arthroplasty (TKA), the medial collateral ligament (MCL) could get completely detached from its distal insertion site. Our aim was to evaluate the (1) mid-term clinical outcome and implant survival after conservative treatment in patients with intraoperatively over-released MCL and (2) preoperative risk factors for MCL over-release. A retrospective study was conducted on patients who had undergone a primary TKA between 2001 and 2006. The number of knees with intraoperative MCL over-release (over-released group) was 47 (40 patients); we compared these with the knees that had intact MCL (intact group, 502 knees). Simple anchoring of MCL was performed with no additional protection. The postoperative clinical outcome and implant survival were compared. Risk factors for MCL over-release were identified using multivariate analysis. The average follow-up period was 7.5 years. The mean Knee Society score of the over-released group improved from 23.3 to 92.7 and it was not significantly different from the intact group. Three cases of aseptic loosening occurred in the over-released group and 19 in the intact group (p = 0.423). The survival rates of the implant were 94.4% and 96.1%, respectively, at 13 years postoperatively. Multivariate analysis showed preoperative femoral–tibial angle as the only risk factor for over-release. This study showed that even MCL was over-released inadvertently, but it did not affect the clinical outcome. Preoperative femoral–tibial angle was the only predictable risk factor for MCL over-release.
Impact of Clinical Presentation on Imaging Evaluation to Direct Effective Treatment Strategies
Authors: Schumacher Christopher , Torabi Maha , Lenchik Leon , Ferguson Cristin , Roller Brandon 
Published: December 2017

AbstractA multitude of musculoskeletal disorders of the knee are commonly encountered in clinical practice. Ensuring an accurate diagnosis can be challenging. It is critical to establish a thoughtful and systematic approach to assessing the patient using history and physical exam followed by appropriate imaging studies. The physical exam may be complicated due to various test maneuvers designed to help make the diagnosis. It is also important to understand the limitations of each physical exam maneuver. When appropriate, imaging is obtained to help make the diagnosis and guide treatment. There are various imaging examinations to choose from when evaluating the knee, including X-rays, computed tomography, magnetic resonance imaging, and ultrasound. An algorithmic approach to choosing the best imaging study is often helpful to avoid unnecessary costs and burden to the patients. The combination of a thorough clinical assessment and appropriate imaging examinations will result in accurate diagnosis, which directs proper treatment.
Chewing Function in Children with Repaired Esophageal Atresia–Tracheoesophageal Fistula
Authors: Serel Arslan Selen , Demir Numan , Karaduman Aynur , Tanyel Feridun , Soyer Tutku 
Published: December 2017

Introduction Feeding problems are common in children with esophageal atresia and tracheoesophageal fistula (EA–TEF); however, chewing disorders, which may cause inability to intake solid food, have not been evaluated. Therefore, we aimed to evaluate the chewing function in children with repaired EA–TEF.
Materials and Methods Age, sex, the type of atresia, the type of repair, and the time to start oral feeding were recorded. The level of the chewing performance was scored according to the Karaduman Chewing Performance Scale (KCPS). The International Dysphagia Diet Standardization Initiative (IDDSI) was used to determine the tolerated food texture in children.
Results A group of 30 patients were included, of which 53.3% was male. The percentages of the isolated-EA and that of the EA–distal TEF were 40% and 60%, respectively. The median value for the time to start oral feeding was 4.5 weeks (min = 1, max = 72). Eleven (36.7%) children had chewing disorder. The KCPS scores showed level I in six cases, level III in four cases, and level IV in one case. Five children with chewing disorder had IDDSI level 3 and six had level 7, along with the sensation of stuck food. We found no significant difference between the KCPS scores according to the repair type (p = 0.07). The median values of the KCPS scores of children with primary repair, delayed repair, and colon interposition were 0 (min = 0, max = 4), 0.5 (min = 0, max = 3), 2 (min = 0, max = 3), respectively. A significant positive correlation was found between the time to start oral feeding and the KCPS scores (r = 0.63, p = 0.001).
Conclusion Chewing disorders can be observed in children with EA–TEF, and the type of repair and the delay in oral feeding may be related to chewing disorder. Therapeutic maneuvers are needed to improve the chewing function in children with EA–TEF.
Stroke Mimics und Stroke Chamäleons – Differenzialdiagnose des Schlaganfalls
Authors: Erbguth Frank 
Published: December 2017

ZusammenfassungDurch die Einführung zeitkritischer Therapieoptionen beim ischämischen Schlaganfall und dem damit verbundenen Druck zum schnellen Handeln
erhöht sich die Wahrscheinlichkeit von diagnostischen Fehleinschätzungen (Stroke Mimics und Stroke Chamäelons). Dieser Beitrag erklärt
dieses Begriffspaar und seine Charakteristika in den unterschiedlichen Behandlungsphasen und zeigt die Möglichkeiten zur Reduzierung der
Rate der Fehldiagnosen auf.
Mögliche Gewalt erkennen und dokumentieren
Authors: Blättner Beate , Grewe Henny Annette 
Published: December 2017

Zusammenfassung
Was tun bei Gewalt? Ein ungutes Gefühl ist ein Grund, genau hinzuschauen, statt wegzusehen. Für Pflegekräfte kann es entlastend sein,
zu wissen, dass sie nicht beurteilen und bewerten müssen, was passiert ist. Ihre Aufgabe ist es lediglich, der pflegebedürftigen Person das
Gefühl von Sicherheit zu geben, relevante Informationen zu sammeln, alle Beobachtungen so genau wie möglich festzuhalten und die gut
dokumentierten Befunde an die Vorgesetzten weiterzugeben.
Aut-idem-Regelung und Inhalatorauswahl bei inhalativer Therapie in pneumologischen und hausärztlichen Praxen unter Alltagsbedingungen – Einschätzung und Umsetzung durch Pneumologen und Hausärzte
Authors: Hering T. , Andres J. , Mohrlang C. , Redeker M. , Schwarz E. 
Published: December 2017

ZusammenfassungDie medikamentöse Therapie obstruktiver Atemwegserkrankungen stützt sich überwiegend auf inhalativ verabreichte Medikamente. Der Erfolg dieser Therapie hängt in entscheidender Weise von der Auswahl des geeigneten Inhalationsgerätes unter Berücksichtigung der Präferenz des Patienten und der korrekten Anwendung ab. Die Aut-idem-Regelung erlaubt ein aktives Ausschließen der Substitutionsmöglichkeit durch den Apotheker und ermöglicht verordnenden Ärzten, die Abgabe eines bestimmten für den Patienten ausgewählten Inhalators, auf den dieser geschult wurde, sicherzustellen. Nichtsdestoweniger zeigt die vorliegende Analyse, dass Pneumologen und im größeren Maße die Hausärzte von dieser Möglichkeit nicht konsequent Gebrauch machen, obwohl sie die Wichtigkeit der gezielten und patientenindividuellen Auswahl eines Inhalationsgerätes erkennen. In der Folge ist festzustellen, dass Patienten in der Apotheke aufgrund von Marktgegebenheiten wie beispielsweise dem Vorliegen von Rabattverträgen oder dem Vorrat abweichende Inhalationsgeräte erhalten. Somit führt der Austausch des Inhalators durch den Apotheker zu Verunsicherung und Anwendungsproblemen bei Patienten. Folglich entsteht eine Gefährdung des Erfolges der vergleichsweise aufwendigen inhalativen Therapie. Diese wäre abwendbar, wenn die Ärzte hinsichtlich des Einsatzes des Aut-idem-Ausschlusses zur Sicherstellung einer optimalen Therapie in konsequenterer Weise informiert und unterstützt würden.
Akutes Koronarsyndrom und Schlaganfall – interdisziplinäres Management
Authors: Zeus Tobias , Jander Sebastian 
Published: December 2017

ZusammenfassungDas akute Koronarsyndrom folgt in Diagnostik und Therapie europäischen Leitlinien. Die interventionelle Therapie steht in der Akutphase im Vordergrund. Ziel ist die Wiederherstellung der Myokardperfusion durch Wiedereröffnung eines verschlossenen oder stenosierten Koronargefäßes. Analog hierzu ist der wesentliche Eckpunkt der Behandlung des akuten Hirninfarkts die zerebrale Rekanalisation. In Abhängigkeit vom zeitlichen Verlauf und der Lokalisation wird dies durch Thrombolyse und/oder endovaskuläre Thrombektomie erreicht. Eine besondere Herausforderung ist das gleichzeitige Auftreten von Schlaganfall und akutem Koronarsyndrom. Da eine Troponinerhöhung in diesem Zusammenhang sowohl eine Dysbalance zwischen Sauerstoffangebot und -bedarf als auch Zeichen einer koronaren Plaqueruptur darstellen kann, sind Anamnese, EKG und Bildgebung besonders wichtig, um die Indikation zur Herzkatheterdiagnostik sicher stellen zu können. Die periinterventionelle und postinterventionelle Gerinnungstherapie sollte interdisziplinär abgestimmt werden und das intrazerebrale Blutungsrisiko berücksichtigen.
Das akute Scrotum im Kindesalter – Juristische Fallstricke
Authors: Bader Pia , Hugemann Christoph , Frohneberg Detlef 
Published: December 2017

ZusammenfassungDas akute Scrotum im Kindesalter ist ein Notfall.Da verschiedene Erkrankungen für plötzliche Scrotalschmerzen verantwortlich sein können, sind die gezielte Anamnese, die Abwägung der DD, eine schnelle Entscheidung und rasches Handeln, zum Beispiel bei einer Hodentorsion, erforderlich.Bei fehlender Einwilligungsfähigkeit des Minderjährigen ist die Einwilligung der Erziehungsberechtigten zwingend erforderlich. Andererseits bereitet deren Einholung im akuten Notfall häufig organisatorische Probleme. Es ergeben sich im täglichen Routinebetrieb durchaus Situationen, in denen gegebenenfalls eine Therapie entschieden werden muss, ohne eine ausreichende Rechtssicherheit durch die rechtzeitige Einwilligung der Erziehungsberechtigten gewährleisten zu können.Je nach Alter und Entwicklung des Kindes u. U. ist auch die Einwilligung des Patienten selbst zu berücksichtigen.Die juristische Bewertung des jeweiligen Einzelfalles und die Erzielung von Rechtssicherheit ist für den behandelnden Arzt und Operateur von wesentlicher Bedeutung.