bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the development of a management protocol for Subjective Cognitive Decline: insights from a cross-sectional and longitudinal analyses of multimodal data from a memory clinic
Authors: Mazzeo Salvatore , Lassi Michael , Padiglioni Sonia , Vergani Alberto Arturo , Moschini Valentina , Scarpino Maenia , Giacomucci Giulia , Burali Rachele , Morinelli Carmen , Fabbiani Carlo , Galdo Giulia , Amato Lorenzo Gaetano , Bagnoli Silvia , Emiliani Filippo , Ingannato Assunta , Nacmias Benedetta , Sorbi Sandro , Grippo Antonello , Mazzoni Alberto , Bessi Valentina 
Published: October 2024

Structured abstractIntroductionSubjective cognitive decline (SCD) is considered as an early symptomatic stage of Alzheimer’s disease (AD). This study aimed to develop a management protocol for SCD based on cross-sectional and longitudinal analyses.MethodsWe enrolled 440 SCD patients who underwent neurological and neuropsychological assessments, MRI scans,APOEgenotyping, and AD biomarker evaluations. Patients were followed for a median of 10 years.ResultsA link was observed between SCD severity, insomnia, and benzodiazepine use. Aβ pathology was identified in 35% of cases. During follow-up, 87 patients progressed to mild cognitive impairment or dementia. The multi-modal clinical profile of each patient was processed by a machine learning model, predicting progression with 74% accuracy and providing a hierarchy of importance of features predicting progression.DiscussionOur findings support the development of a personalized clinical management protocol for SCD that considers demographic, clinical, cognitive and biological factors for both baseline characterization and prognostic purposes.
Based on breast CEUS parameters combined with serum CA153, a nomogram model was constructed to predict the molecular classification of breastcancer
Authors: Ji Yanlei , Han Zhen , Zhang Yong , Sun Wenwen 
Published: October 2024

AbstractObjectiveTo analyze the role of contrast-enhanced ultrasound (CEUS) parameters combined with serum tumor marker CA153 in the prediction of Breast Cancer (BC) molecular typing.MethodsFrom January 2020 to January 2023, 120 BC patients diagnosed in our hospital were studied. According to the pathological results, the patients were divided into Luminal and non-Luminal BC groups. Both groups underwent contrast-enhanced ultrasoun. The time-intensity curve (TIC) is obtained, and the relevant characteristic parameters are obtained, including peak intensity (PI), peak time (TTP), area under the curve (AUC), and mean transit time (MTT). Serum tumor marker CA153 was detected in both groups. Combined with CEUS characteristic parameters and serum CA153 of two groups of BC patients, a multiple Logistic regression model was constructed, and a nomogram prediction model was constructed based on the model. Calibration curve and receiver operating characteristic (ROC) curve were used to analyze the value of this model in the prediction of BC molecular classification.ResultsThere were no significant differences between Luminal BC patients and non-Luminal BC patients in clinical parameters and qualitative parameters of contrast-enhanced ultrasound, while there were statistical differences between quantitative parameters PI, AUC and serum tumor marker CA153. The AUC of the combined diagnosis of three parameters (PI, AUC and CA153) was significantly higher than that of the single index diagnosis group. The ROC curve AUC of BC molecular typing was predicted to be 0.94 based on the three-parameter nomogram, and the fitting of the actual curve and the ideal curve in the calibration curve was close.ConclusionsThe nomogram model based on breast contrast-enhanced ultrasound (CEUS) parameters combined with serum CA153 can effectively predict the molecular classification of BC.
Evolution of plasmid domestication in plant-associatedPantoea: massive gain of genetic redundancy followed by differential gene loss
Authors: Picazo Devani Romero , Kwasigroch Paul , Hülter Nils F. , Dagan Tal 
Published: October 2024

AbstractPlasmids are important drivers of evolutionary transformations and ecological adaptation in prokaryotes. Plasmids supplying the host with beneficial functions may become domesticated and gain a stable inheritance within the host lineage in the form of secondary chromosomes. Chromosomes descendent from plasmids (termed chromids) comprise core genes that are universally present in all taxon members. The origin of plasmid core genes remains poorly understood and alternative hypotheses entailing gene translocation or genetic redundancy are debated. Studying plasmid evolution in plant-associatedPantoea, we show that the largePantoeaplasmid (LPP) and plasmid pPag1 comprise core genes in the host taxa. We infer the LPP acquisition in plant-associated ancestors, while the pPag1 acquisition is traced to the ancestor of plant growth-promoting species. We show that both plasmids are vertically inherited and the LPP replication is furthermore coordinated with cell division, hence they are better described as chromids. Using phylogenomics we infer that the plasmid acquisition manifested in massive gene gain, some redundant with the chromosome, followed by differential gene loss. Our results provide an explanation for the evolution of core plasmid genes that entails plasmid-driven species divergence, which preliminarily manifests in genetic redundancy, and is followed by gradual loss of redundant genes.Significance statementAdaptation to host-associated lifestyle in bacteria can be promoted by the acquisition of plasmids, which are mobile extra-chromosomal genetic elements. A canonic example is the symbiosisRhizobiaplasmids, where essential traits to interact with Legumes are plasmid-encoded. Symbiosis plasmids are likely to evolve into stably inherited domesticated plasmids (termed chromids). Recent research reveals that potential chromids are widely distributed among plant-associated bacteria. Studying the origin of plasmids in the plant-associated genusPantoea, we show that the largePantoeaplasmid (LPP) and plasmid pPag1 are domesticated. Phylogenomic analyses trace back the plasmid origin to ancestral nodes in thePantoeaspecies tree. We reconstruct main events in chromid evolution, including massive gene gain, some redundant with the chromosome, and differential gene loss.
Tuberculosis Following In Vitro Fertilization: A Systematic Review of Case Reports, Case Series, and Cohort Studies
Authors: Garg Ravindra Kumar , Malhotra Hardeep Singh , Suresh Vinay , Garg Rajiv , Jain Amita , Gupta Sarika , Agrawal Smriti 
Published: October 2024

AbstractIntroductionTuberculosis (TB) remains a leading global health threat, with increasing concerns regarding post-in vitro fertilization (IVF) TB, especially in high-burden areas. Post-IVF maternal TB poses serious risks to both pregnant women and fetuses, often leading to miscarriage, fetal malformation, or mortality. Congenital TB, though rare, can result from maternal infection, with potentially devastating outcomes.MethodsA systematic review of case reports, case series, and cohort studies was conducted following PRISMA guidelines. Databases including PubMed, Scopus, Embase, and Google Scholar were searched until October 7, 2024, for studies related to TB following in vitro fertilization. Cases were evaluated for clinical presentations, diagnostics, treatment, and outcomes. We separately reviewed 11 cohort studies due to the lack of available individual patient data and the considerable variability in their methodologies.ResultsThirty-seven reports comprising 48 cases were analyzed, with the majority from Asia. Post-IVF TB is commonly presented as miliary TB in mothers, with systemic involvement including pulmonary, central nervous system (CNS), and genitourinary manifestations. Newborns frequently develop congenital TB, presenting with respiratory distress and neurological issues. The diagnosis was confirmed through techniques such as sputum polymerase chain reaction (PCR), endometrial biopsies, and imaging. Maternal outcomes improved with anti-TB therapy, while neonatal outcomes varied, with high mortality rates.ConclusionPost-IVF TB manifests in mothers as miliary TB with systemic involvement; congenital TB in newborns often leads to respiratory distress, neurological complications, and high mortality. TB screening before IVF is critical in high-risk regions to prevent severe maternal and neonatal complications.
Harnessing GPT-4 for Automated Curation of E3-Substrate Relationships in the Ubiquitin-Proteasome System
Authors: Zhang Zhiqian , Elledge Stephen J. 
Published: October 2024

AbstractThe ubiquitin-proteasome system (UPS) is a complex regulatory network involving around 600 E3 ligases that collectively govern the stability of the human proteome by targeting thousands of proteins for degradation. Understanding this network requires integrating vast amounts of information on gene and protein interactions scattered across unstructured literature. Historically, manual curation has been the gold standard for transforming such data into structured databases, but this process is time-consuming, prone to error, and unable to keep up with the rapid growth of scientific publications. To address these limitations, we developed a scalable, cost-effective workflow using GPT-4, a large language model (LLM), to automate the curation of degradative E3-substrate relationships from the literature. By mining approximately two million PubMed papers, we identified 7,829 degradation-related abstracts and curated a structured database of 3,294 unique E3-substrate pairs using GPT-4, achieving an annotation accuracy rate approaching that of human experts. The resulting database of E3-substrate pairs offers valuable insights into the ubiquitin-proteasome system by highlighting understudied E3s and previously unknown UPS substrates in proteome-wide stability experiments. This automated approach represents substantial increase in productivity compared to manual curation and stands as the largest effort to date utilizing LLMs for the automated curation of protein-protein regulatory relationships. We further showed that our approach is generalizable to other enzyme-substrate families, such as deubiquitinases, kinases, and phosphatases. Overall, our study demonstrates the potential of LLMs as a scalable technology for large-scale curation of signalling relationships, substituting and complementing manual curation to accelerate biological research.
The window of opportunity: a case study of the battery electric vehicle in Thailand
Authors: Intarakumnerd Patarapong , Charoenporn Peera 
Published: October 2024

Purpose
Thailand, although a late entrant, has emerged as a significant center for the production and export of internal combustion engine (ICE) vehicles in Asia. With the arrival of a disruptive battery-electric vehicle (BEV), this study aims to investigate whether Thailand can exploit this window of opportunity to leapfrog.

Design/methodology/approach
This paper uses data sourced from Thailand’s Department of Intellectual Property to analyze electric vehicle (EV) patent applications. This paper collected qualitative data and conducted interviews with several EV manufacturers.

Findings
Although Japanese automakers dominate essential EV technology patents, they trail behind Chinese automakers, which benefited from the Free Trade Agreement (FTA) in EV sales. The incumbents, Japanese and Western, choose to expand their production of hybrid electric vehicles (HEVs) and plug-in hybrid vehicles. ICE technology does not constrain new entrants, such as Chinese automakers, Japanese newcomers and Thai newcomers. Compared to Japanese carmakers stuck with ICE and HEV technologies, they have been transitioning to BEVs at a faster pace. BEV has opened the door for large Thai indigenous energy corporations to enter the automotive industry by focusing on niche areas (nonfour-wheel vehicles) and supporting businesses like charging stations. In summary, Thailand has successfully attracted foreign direct investment (FDI) into the EV sector, but it has not yet succeeded in developing indigenous technologies related to EVs. The Thai automobile sector fails to leapfrog because it is too tied up with Japanese automotive production networks and has an unfavorable FTA with China.

Originality/value
This study sheds light on the limitations of an industrial development strategy relying on openness to trade and FDI without adequately strengthening indigenous technologies and firms, as the country adopting the strategy fails to leapfrog when the window of opportunities created by disruptive technologies arrives.
Unleashing the missing link between work-family conflict and affective commitment: implications for health professionals
Authors: Iqbal Juman , Shagirbasha Shameem , Kumar Madhan , Mufeed S.A. 
Published: October 2024

PurposeElucidating on the theoretical framework of conservation of resource and social identity theories, we aim to explore the association between work-family conflict (bidirectional, i.e. work-to-family conflict (WFC) and family-to-work conflict (FWC)) and affective commitment (AC) via emotional exhaustion (EE). Besides, the buffering effect of organizational identification (OI) in the bi-directional work-family conflict and EE relationship and perceived interactional justice (PIJ) between EE and AC were also tested.Design/methodology/approachA multi-time study was conducted in which data from 675 doctors working in different public hospitals across India were gathered at three-time intervals (T1, T2 and T3). The collected data were then analyzed using statistical software tools, namely AMOS 24 and SPSS v23.FindingsIt was indicated that WFC and FWC have a significant negative association with AC. EE was shown to mediate the relationship between bi-directional work-family conflict and AC. Additionally, OI buffered the relationship between WFC, FWC and EE. Moreover, PIJ was established as a moderating factor in the relationship between EE and AC.Originality/valueThis paper provides a new insight into the work-family conflict-AC relationship by examining it through the mediating role of EE. It offers a nuanced understanding by establishing the buffering effects of OI in the bi-directional WFC and EE. To our knowledge, this research represents the inaugural attempt to investigate the moderating influence of PIJ in the relationship between EE and AC.
Unpacking the complexity of online incivility: an analysis of characteristics and impact of uncivil behavior during the Hong Kong protests
Authors: Li Baiqi , Song Yunya , Shi Yongren , Chen Hsuan-Ting 
Published: October 2024

PurposeThis study seeks to establish a new framework for categorizing incivility, differentiating between explicit and implicit forms, and to investigate their respective abilities to proliferate and mobilize conversations, along with behavioral outcomes in various social contexts.Design/methodology/approachEmploying computational techniques, this research analyzed 10,145 protest-related threads from the HK Golden Forum, a prominent online discussion board in Hong Kong.FindingsOur analysis revealed divergent effects of explicit and implicit incivility on their diffusion, influences on deliberative discussions, and user participation. Explicit incivility was found to impede deliberative conversations, while implicit incivility tended to provoke more responses. Explicit uncivil expressions encouraged the propagation of incivility but reduced the likelihood of individual involvement. In contrast, implicit incivility had a stronger dampening effect on further uncivil comments and achieved greater thread popularity. The results showed strong associations between uncivil expressions and the contextual norms surrounding social movements.Originality/valueTheoretically, this research introduced a classification of incivility and underscored the importance of differentiating between implicit and explicit incivility by examining their effects on deliberation and engagement. Although previous studies have extensively covered explicit incivility, this study goes further by analyzing implicit incivility and comparing both forms of uncivil discourse in a less-studied context. Methodologically, the study developed a Cantonese dictionary to differentiate between two types of incivility, providing a practical reference for more nuanced analyses. By revealing how varying movement norms moderate the interplay between deliberative and uncivil expressions, the study drew attention to the highly situational nature of incivility.
What drives social shopping in social commerce platform? The effects of affordance, self-congruity and functional-congruity
Authors: Gong Xiang , Yang Yi , Wu Wei 
Published: October 2024

PurposeSocial group system and social tagging system, which leverage the psychological mechanisms underlying group influence and social tags to drive consumer behaviors, have been prevalent in the social commerce platform. However, limited studies have examined how the affordances of social group system and social tagging system influence consumers’ social shopping behavior. The purpose of this study is to examine the formation of social shopping behavior in the social commerce platform.Design/methodology/approachCombining affordance theory with dual-congruity theory, we develop a model to examine how the affordances of social group system and social tagging system influence consumers’ social shopping behavior through the underlying self-congruity and functional-congruity processes. We empirically validate the research model using a multimethod approach, including an instrument development study and a field survey study.FindingsOur empirical findings show that social support positively influences relational identity, while it has a nonsignificant effect on social identity. Social interactivity positively influences relational identity and social identity. Furthermore, social tagging quality and social endorser credibility positively affect perceived diagnosticity and perceived serendipity. Finally, relational identity, social identity, perceived diagnosticity and perceived serendipity collectively determine consumers’ social shopping intention.Originality/valueThis study contributes to the theoretical understanding of social shopping in social commerce and offers practical implications for designing an effective social group system and social tagging system to boost product sales.
Ethical leadership and followers’ job crafting: the mediating role of followers’ role-breadth self-efficacy and work engagement
Authors: Oprea Bogdan , Oancea Denisa , Avram Eugen 
Published: October 2024

PurposeThe objective of this study was to investigate the link between ethical leadership and followers’ job crafting. Based on social learning theory and the job demands-resources model, we expected that followers’ role-breadth self-efficacy and work engagement would serially mediate the association between this leadership style and followers’ job crafting.Design/methodology/approachA quantitative analysis was conducted among a sample of 458 subordinates that assessed the ethical leadership of their direct supervisor and reported on their own role-breadth self-efficacy, engagement and job crafting behaviours.FindingsEthical leadership was positively associated with followers’ increasing structural resources, increasing social resources and increasing challenging demands. The mediation hypothesis was supported for increasing challenging demands but not for increasing social resources. Results unexpectedly suggested that the indirect positive effect suppresses the direct negative effect of ethical leadership on followers’ increasing structural resources, the total effect becoming positive. This leadership style was not associated with followers’ decreasing hindering demands.Practical implicationsThe research highlights the possibility that ethical leadership trainings may stimulate followers' job crafting.Originality/valueThe study explores for the first time the relationship between this leadership style and job crafting behaviours of subordinates and, moreover, provides an explanatory mechanism for the relationship between these variables.
Unlocking proactive socialization dynamics: investigating work engagement through social capital resources, the interplay of proactive personality and perceived organizational support
Authors: Islam Azmat , Ajmal Muhammad 
Published: October 2024

PurposeThis study aims to explore the relationship between proactive socialization behaviors (PSBs) and work engagement, with a specific focus on the mediating role of social capital resources (SCRs). Additionally, it investigates how proactive personality and perceived organizational support (POS) moderate the organizational assimilation of newcomers in Punjab, Pakistan, through the lens of self-determination theory.Design/methodology/approachA cross-sectional survey design was employed, with data collected from diverse organizations across cities in Punjab, Pakistan, including Bhimber, Gujrat, Gujranwala, Lahore, Jhelum, Kharian, Kotla, Mandi Bahauddin, and Sialkot. A total of 1,000 questionnaires were distributed, resulting in 619 valid responses. The sample primarily consisted of individuals with varying levels of work experience, contributing to the diversity of the data. SEM was utilized to analyze the relationships between the studied variables.FindingsResults indicated a significant positive association between PSBs and work engagement among newcomers. SCRs were found to mediate this relationship, suggesting that proactive behaviors help newcomers accumulate social capital, which enhances work engagement. Moreover, the study reveals that proactive personality and POS significantly moderate the relationship between PSBs and work engagement, with stronger positive associations observed among proactive individuals and those perceiving higher organizational support.Practical implicationsThe study underscores the importance of encouraging proactive socialization behaviors and strengthening organizational support systems to foster newcomer engagement and facilitate successful assimilation.Social implicationsUnderstanding these dynamics can lead to the creation of more inclusive and supportive organizational environments, enhancing both individual well-being and organizational effectiveness.Originality/valueThis research offers new insights into the mechanisms through which PSBs impact work engagement, particularly through the accumulation of SCRs, and highlights the importance of proactive personality and organizational support as moderators.