bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psoriasis in patients with mycosis fungoides: a clinicopathological study of 25 patients
Authors: Nikolaou V. , Marinos L. , Moustou E. , Papadavid E. , Economidi A. , Christofidou E. , Gerochristou M. , Tasidou A. , Economaki E. , Stratigos A. , Antoniou C. 
Published: May 2017

AbstractBackgroundIt has been reported that patients with psoriasis are at increased risk for developing lymphoma including cutaneous T‐cell lymphomas (CTCL). However, the comorbidity and the histopathologic correlation of psoriasis and mycosis fungoides (MF) have been less studied.ObjectiveThe objective of this study was to investigate the relation between MF and psoriasis.MethodsWe retrospectively reviewed and re‐evaluated all MF cases diagnosed and followed in a 16‐year period who carried both MF and psoriasis diagnoses.ResultsForty‐one of 321 MF patients was the rate of psoriasis’ comorbidity according to medical records. Twenty‐five patients (7.8%) finally met the inclusion criteria. The rest were excluded due to inadequate evidence. Twenty patients had psoriatic lesions at the time of MF diagnosis. In 23 patients, there was histological confirmation of both diseases. Six patients (24%) were diagnosed with folliculotropic MF, two were diagnosed with pustular psoriasis, and six patients were affected by palmoplantar and nail psoriasis. In four patients, there was a very short time interval between MF and psoriasis diagnosis. Fourteen patients with psoriasis had been previously treated with immunomodulatory regimens. Interestingly, in eight patients, typical histological findings of both diseases were detected in the same biopsy specimen.ConclusionOur results support the opinion that the association between psoriasis and MF does exist. It is most possibly related to the chronic lymphocyte stimulation that occurs during psoriasis that eventually leads to a dominant clone and the evolution to CTCL. Our study suggests that apart from cases of early MF, which are being indeed misdiagnosed as psoriasis, there is another group of patients, where psoriasis truly coexists with – or even progresses to – MF.
Examining the role of the physician as a source of variation: Are physician‐related variations necessarily unwarranted?
Authors: Mercuri Mathew , Gafni Amiram 
Published: May 2017

AbstractRationale, Aims, and ObjectivesThe physician is often implicated as an important cause of observed variations in health care service use. However, it is not clear if physician‐related variation is problematic for patient care. This paper illustrates that observed physician‐related variation is not necessarily unwarranted.MethodsThis is a narrative review.ResultsMany studies have attributed observed variations to the physician, but little attention is given towards discriminating between those variations that exist for good reasons and those that are unwarranted. Two arguments can be made for why physician‐related variation is unwarranted. The first posits that physician‐related factors should not play a role in management of care decisions because such decisions should be driven by science (which is imagined to be definitive). The second considers the possibility of supplier‐induced demand as a factor driving observed variations. We show that neither argument is sufficient to rule out that physician‐related variations may be warranted. Furthermore, the claim that such variations are necessarily problematic for patients has yet to be substantiated empirically.ConclusionsIt is not enough to simply show that physician‐related variation can exist—one must also show where it is unwarranted and what is the magnitude of unwarranted variations. Failure to show this can have significant implications on how we interpret and respond to observed variations. Improved measurement of the sources of variation, especially with respect to patient preferences and context, may help us start to disentangle physician‐related variation that is desirable from that which is unwarranted.
Influence of high pressure homogenization with and without lecithin on particle size and physicochemical properties of whey protein‐based emulsions
Authors: Yan Bing , Park Sung Hee , Balasubramaniam V. M. 
Published: May 2017

AbstractThis study evaluated the quality attributes of high pressure homogenized whey protein emulsions with and without lecithin. Samples were prepared by mixing whey protein concentrate (10%), soybean oil (0 or 5%) and soy lecithin (0 or 5%). The premixtures were processed by a laboratory scale high pressure homogenizer at various pressures (25, 50, 75, and 100 MPa) at an initial temperature of 21 °C. The samples were evaluated for particle size, electrical conductivity, color, °Brix, and pH. Increasing homogenization pressures significantly decreased particle sizes of all samples. After 25 MPa treatment, emulsions with lecithin had smaller particle sizes than those made without lecithin. However, lecithin did not further reduce particle size for emulsion samples treated at ≥50 MPa. Electrical conductivity of samples increased with increasing homogenization pressures. Homogenization increased the lightness (L*) while reduced redness (a*) and yellowness (b*) of emulsions. The °Brix of emulsions increased after homogenization, but no change in pH was observed.Practical applicationsConsumer interest in clean label products prompted the food industry to investigate various processing methods such as high pressure homogenization to reduce additive use. The results of this study demonstrated the potential of applying high pressure homogenization in preparing whey protein‐based food products, with less use of lecithin.
Beyond the Individual: The Interdependence of Advance Directive Completion by Older Married Adults
Authors: Koss Catheryn S. 
Published: May 2017

ObjectivesTo determine how individual and spousal demographic and health factors are associated with advance directive (AD) completion by married older adults.DesignDyadic structural equation modeling using the Actor‐Partner Interdependence Model.SettingThe 2004 to 2012 waves of the Health and Retirement Study.ParticipantsCommunity‐dwelling heterosexual married couples aged 65 and older (N = 2,243).MeasurementsStructural equation modeling with a probit link function was used to estimate associations between men's and women's age, education, health status, prior hospitalization or outpatient surgery in the past 10 years, regular health care provider, and household net assets and their own and their spouses’ probabilities of having an AD.ResultsIndividual and spousal ages were each positively associated with AD completion for men and women. Those with higher education were more likely to possess ADs. Women's probabilities of having ADs were also positively associated with husbands’ education. Men whose wives’ were in poor health were less likely to have ADs. Men who were hospitalized or underwent outpatient surgery were more likely to have ADs, as were their wives. Women who had regular sources of health care were more likely to have completed ADs.ConclusionAD completion by older married adults is associated with both individual and spousal factors. How spouses influence one another's advance care planning differs by gender. Future research should account for the dyadic nature of advance care planning, as should public education efforts and interventions promoting AD completion.
A novel method to analyse in vivo the physiological state and cell viability of phototrophic microorganisms by confocal laser scanning microscopy using a dual laser
Authors: MILLACH LAIA , OBIOL ALEIX , SOLÉ ANTONIO , ESTEVE ISABEL 
Published: May 2017

SummaryPhototrophic microorganisms are very abundant in extreme environments, where are subjected to frequent and strong changes in environmental parameters. Nevertheless, little is known about the physiological effects of these changing environmental conditions on viability of these microorganisms, which are difficult to grow in solid media and have the tendency to form aggregates. For that reason, it is essential to develop methodologies that provide data in short time consuming, in vivo and with minimal manipulating the samples, in response to distinct stress conditions.In this paper, we present a novel method using Confocal Laser Scanning Microscopy and a Dual Laser (CLSM‐DL) for determining the cell viability of phototrophic microorganisms without the need of either staining or additional use of image treating software. In order to differentiate viable and nonviable Scenedesmus sp. DE2009 cells, a sequential scan in two different channels was carried out from each same xyz optical section. On the one hand, photosynthetic pigments fluorescence signal (living cells) was recorded at the red channel (625‐ to 785‐nm fluorescence emission) exciting the samples with a 561‐nm laser diode, and an acousto‐optic tunable filter (AOTF) of 20%. On the other hand, nonphotosynthetic autofluorescence signal (dead cells) was recorded at the green channel (500‐ to 585‐nm fluorescence emission) using a 405‐nm UV laser, an AOTF of 15%. Both types of fluorescence signatures were captured with a hybrid detector.The validation of the CLSM‐DL method was performed with SYTOX green fluorochrome and electron microscopic techniques, and it was also applied for studying the response of distinct light intensities, salinity doses and exposure times on a consortium of Scenedesmus sp. DE2009.
A rare complication of topical atropine for treatment of eccrine hidrocystoma: Pharmacological fixed dilated pupils
Authors: Zandi Alireza , Abtahi‐Naeini Bahareh , Pourazizi Mohsen 
Published: May 2017

SummaryMultiple eccrine hidrocystoma (EH) has been treated with topical atropine with variable results. However, in rare cases, anticholinergic side effects have been seen after the use of the topical form of this drug. We presented a 50‐year‐old woman who developed recent onset of visual disturbance and photophobia from 2 weeks prior. The diagnosis of topical atropine‐induced bilateral mydriasis was made. We reported a recognized but often overlooked case of bilateral mydriasis caused by application of topical 1% atropine for treatment of multiple EH.
Exchanging narratives—A qualitative study of peer support among surgical lung cancer patients
Authors: Borregaard Britt , Ludvigsen Mette Spliid 
Published: May 2017

Aim and objectiveThe aim of this study was to examine how hospitalised, surgical lung cancer patients experience talking to a former patient, and how the former patient experiences the role as supportive.BackgroundDuring hospitalisation, patients often create a community in which they can engage with fellow patients. The exchange of experiences with others in a similar situation might increase opportunities for support and complement nursing care, but there is a need for more evidence and understanding on the topic.DesignThe methodological framework is based on the French philosopher Paul Ricoeur's text interpretation theory. Qualitative interviews were conducted with nine patients, including a peer informant, using a narrative structure. The analysis was conducted on three levels: (i) naïve reading, (ii) structural analysis and (iii) critical interpretation .ResultsFour themes were developed from the analysis of the interviews: Exchanging emotional thoughts is easier with a peer; Talking to a peer reduces loneliness; Being ambiguous about a relationship with fellow patients; and Being the main person in the conversation with a peer. Sharing stories about having similar symptoms and undergoing similar journeys predominated, and the key feature of the contact between patients was the commonality of their stories.Critical interpretation and conclusionTelling one's story to a former patient, and thereby creating a joint, common story, is the essence of this study. The support received in this process can be empowering because knowledge of the illness experience is shared and increased. This can help create new coping strategies. The contact with a former patient offered a way to confirm one's thoughts and to find a way out of the illness perspective, by seeing how the former patient had recovered.Relevance to clinical practiceThe nursing field faces challenges in the relational aspect of caring because of ever greater efficient and shortened hospital stays; therefore, the peer support concept is becoming increasingly relevant. Patient peers offer each other their own perspectives, and it is important to raise awareness of the value of this and incorporate it into patient stays in hospital.
Multiple placental surface cysts with intracystic hemorrhaging: A case report and review of the literature
Authors: Soyama Hiroaki , Miyamoto Morikazu , Sasa Hidenori , Yoshida Masashi , Takano Masashi , Furuya Kenichi 
Published: May 2017

AbstractA placental surface cyst is a cystic mass arising from the surface of the placenta. It is seldom complicated by intracystic hemorrhaging and the clinical importance of this kind of case is unclear. Therefore, we present a case of a placental surface cyst with intracystic hemorrhaging. A 29‐year‐old multiparous woman was diagnosed with multiple placental surface cysts with threatened preterm birth and fetal growth restriction on ultrasonography at 26 gestational weeks (GW). At 31 GW, the hemorrhage was identified inside the cyst. At 32 GW, she presented with placental abruption, and emergency cesarean section was performed. Both the mother and her baby survived. Placental surface cysts up to 77 × 65 mm in diameter containing old hemorrhages were discovered, and pathological examination revealed hemosiderin and fibrin deposition. Pregnancy with a placental surface cyst with intracystic hemorrhaging may have the potential for severe obstetric complications.
Everolimus in pregnancy: Case report and literature review
Authors: Yamamura Mie , Kojima Takashi , Koyama Masayuki , Sazawa Ataru , Yamada Takahiro , Minakami Hisanori 
Published: May 2017

AbstractThere have been few reports on the effects of everolimus on the fetus, but none of six infants with documented everolimus exposure in utero had congenital malformations. A 32‐year‐old nulliparous woman on everolimus (5.0 mg/day) for renal angiomyolipoma (AML) due to tuberous sclerosis complex (TSC) was found to be pregnant at gestational week (GW) 7–5/7, at which time everolimus was withheld. To control AML in this patient, transarterial embolization was performed in the right and left kidneys at GW 21 and 24, respectively, and everolimus was reinitiated at GW 25. The patient gave birth at GW 37 to a normally formed infant weighing 3057 g, but who had cardiac tumors thought to be rhabdomyomas due to inherited TSC. Thus, although data are still limited, everolimus may be promising with respect to teratogenicity. Everolimus concentration in the maternal and umbilical cord blood at birth was 1.1 ng/mL and 1.0 ng/mL, respectively.
Mineral Composition of Uroliths Obtained from Sheep and Goats with Obstructive Urolithiasis
Authors: Jones M.L. , Gibbons P.M. , Roussel A.J. , Dominguez B.J. 
Published: May 2017

BackgroundKnowledge of the mineral composition of the causative urolith is important to develop preventative strategies. Advances in analytic techniques have led to detection of urolith components not previously recognized.Hypothesis/ObjectivesThe objectives of this study were to characterize uroliths in sheep and goats structurally and clinically. We hypothesized that amorphous magnesium calcium phosphate (AMCP) would be a naturally occurring urolith type in sheep and goats.AnimalsForty‐nine sheep and goats presenting for obstructive urolithiasis from June 15, 2014 through June 14, 2016 were reviewed along with the demographic data of all small ruminants admitted during that same period.MethodsMedical records were reviewed for demographic and historical data, and 36 uroliths obtained from these cases during diagnostic or therapeutic procedures were analyzed by infrared spectroscopy to determine chemical composition.ResultsAMCP is a naturally occurring urolith type in obstructed male sheep and goats and was the most common urolith type in this study, where it occurred as a majority component with struvite (39% of uroliths) or as a pure component (11%). Pure struvite was found in 1 urolith (2%). Calcium carbonate was the second most frequent urolith with 31% of uroliths being pure calcium carbonate.Conclusions and Clinical ImportanceThis study demonstrates that uroliths, which appear consistent with struvite, could actually be calcium‐containing AMCP. Urolith analysis is critical in determining mineral content of uroliths to guide dietary recommendations for prevention.
Increased incidence of liver cancer after successful DAA treatment of chronic hepatitis C: Fact or fiction?
Authors: Alberti Alfredo , Piovesan Sara 
Published: May 2017

AbstractTherapy of hepatitis C has been revolutionized by Direct Antiviral Agents. These drugs are safe and efficacious in all infected patients, including those with advanced, or decompensated cirrhosis, and are currently largely used in such cases in clinical practice worldwide. It was therefore cause of great concern the publication of two reports suggesting that treatment with DAAs could increase the risk of hepatocellular carcinoma in cirrhotic patients, particularly in those receiving antiviral therapy after having been cured for an HCC. These reports have generated a great and controversial debate and have been followed by a series of other publications not confirming such increased risk. This article summarizes published studies assessing the relation between DAA therapy and HCC in two different clinical setting: HCC recurrence in patients with an history of cured HCC and “de novo” HCC occurrence in patients without previous HCC. Rates of HCC recurrence after DAAs were extremely variable in different studies, reflecting great heterogeneity of this clinical setting. Data on “de novo” HCC incidence were more homogeneous and suggest that treatment with DAAs is not modifying the risk of developing HCC in the first 6‐12 months. The possibility that treatment with DAAs may favour tumour growth and spread in individual patients with active HCC foci is suggested by some observations but remains unproven. There is clearly a need for prospective studies designed to better define these issues.
Genetic engineering of grass cell wall polysaccharides for biorefining
Authors: Bhatia Rakesh , Gallagher Joe A. , Gomez Leonardo D. , Bosch Maurice 
Published: May 2017

SummaryGrasses represent an abundant and widespread source of lignocellulosic biomass, which has yet to fulfil its potential as a feedstock for biorefining into renewable and sustainable biofuels and commodity chemicals. The inherent recalcitrance of lignocellulosic materials to deconstruction is the most crucial limitation for the commercial viability and economic feasibility of biomass biorefining. Over the last decade, the targeted genetic engineering of grasses has become more proficient, enabling rational approaches to modify lignocellulose with the aim of making it more amenable to bioconversion. In this review, we provide an overview of transgenic strategies and targets to tailor grass cell wall polysaccharides for biorefining applications. The bioengineering efforts and opportunities summarized here rely primarily on (A) reprogramming gene regulatory networks responsible for the biosynthesis of lignocellulose, (B) remodelling the chemical structure and substitution patterns of cell wall polysaccharides and (C) expressing lignocellulose degrading and/or modifying enzymes in planta. It is anticipated that outputs from the rational engineering of grass cell wall polysaccharides by such strategies could help in realizing an economically sustainable, grass‐derived lignocellulose processing industry.
Transcatheter arterial embolization in normal canine liver
Authors: Oishi Yasuhisa , Tani Kenji , Ozono Koushiro , Itamoto Kazuhito , Haraguchi Tomoya , Taura Yasuho 
Published: May 2017

AbstractObjectiveTo determine the effects of selective transcatheter arterial embolization (TAE) in the normal canine liver.Study designExperimental study.AnimalsAdult Beagle dogs (n = 5).MethodsGelatin sponge particles (GSPs) were injected through a microcatheter for selective embolization of the left hepatic artery in normal dogs. Computed tomography (CT) and histology were performed during an 8‐week observation period; biochemical analysis data were obtained during a 12‐week observation period after TAE.ResultsEmbolization was successful in all dogs and did not induce any change in the clinical appearance of dogs. Postoperative CT was consistent with recanalization of the artery within 2 weeks of embolization in all dogs. Hepatic enzyme levels increased temporarily after embolization but gradually returned to normal ranges. Histological examinations did not differ between treated and untreated liver tissues.ConclusionTAE appears safe in normal dogs observed for 12 weeks. Arterial recanalization seems to occur within 2 weeks after injection of GSPs in the left hepatic artery.Impact/clinical relevanceSelective TAE of the hepatic artery was well tolerated in normal dogs. Selective TAE may be applicable to canine hepatocellular carcinoma.
Accelerometer-Measured Patterns of Shared Physical Activity Among Mother–Young Child Dyads
Authors: Dlugonski Deirdre , DuBose Katrina Drowatzky , Rider Patrick 
Published: May 2017

Background:Many mothers and young children are not meeting physical activity guidelines. Parent–child coparticipation in physical activity (ie, shared physical activity) provides opportunities for social modeling and might be associated with child physical activity. There is very little information about shared physical activity using objective measures.Methods:Participants (N = 17 mother–young child dyads) completed a demographic survey and height/weight measurements, and wore a Bluetooth® accelerometer for 1 week. Accelerometers were initialized using the proximity function to yield both individual and proximity [a minute-by-minute log of whether the 2 accelerometers were in- or out-of-range (∼50 m or less)] data. Shared physical activity was calculated in MATLAB by overlaying individual and proximity accelerometer data.Results:Mother–child dyads spent approximately 2 hours per day in shared time that was mostly shared sedentary activities. Less than 1% of shared minutes per day were spent in shared moderate to vigorous physical activity.Conclusions:Mothers and young children spent a small portion of their day in shared activities. Most mother–child shared time was spent in sedentary or light activities rather than moderate to vigorous physical activity. This method for objectively measuring shared physical activity provides novel information about the context in which physical activity occurs and could be used to understand patterns of physical activity among other dyads.