bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Characterizes Depression in Old Age? Results from the Bruneck Study
Authors: Defrancesco Michaela , Pechlaner Raimund , Kiechl Stefan , Willeit Johann , Deisenhammer Eberhard , Hinterhuber Hartmann , Rungger Gregor , Gasperi Arno , Marksteiner Josef 
Published: September 2017

Abstract
Introduction Depression in old age is associated with functional disabilities, cognitive impairment, lower self-rated quality of life, and increased mortality. The aim of the study was to reveal the prevalence of depression and to investigate the characteristics of patients treated with antidepressants.
Methods We analyzed data from the Bruneck Study 2010. All participants completed a clinical examination, cognitive screening, the 30-item Geriatric Depression Scale (GDS) (cutoff score of>8 to define relevant depressive symptoms), and the World Health Organization quality of life questionnaire (WHO-QoL). Group differences were calculated using binary logistic regression analysis.
Results Out of 456 participants (mean age of 73.1±8.2 years), 22.1% showed depressive symptoms, and out of these, 30% were taking antidepressants. The depressed group compared to the GDS ≤8 group showed significantly lower WHO-QoL (p<0.001) and Mini Mental State Examination (p=0.015) score. Further, 13% of the latter compared to the GDS>8 group received antidepressants, and these had a lower WHO-QoL score (p<0.033).
Discussion Depressive symptoms are frequent in the elderly population. Our results confirm the negative influence of depressive symptoms on cognition and quality of life. Patients with somatic comorbidities are likely to receive more antidepressant medication.
Grincamycins I – K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32
Authors: Lai Zhenzhu , Yu Jianchen , Ling Huiping , Song Yongxiang , Yuan Jie , Ju Jianhua , Tao Yiwen , Huang Hongbo 
Published: September 2017

AbstractThree new angucycline glycosides, designated grincamycin I (1), J (2), and K (3), together with the known congener A-7884 (4), were isolated from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2 and 4 exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC50 values ranging from 0.4 to 6.9 µM. In addition, A-7884 (4) demonstrated antimicrobial activity against Micrococcus luteus with an MIC value of 1.95 µg/mL.
L’interface geste-signe dans l’acquisition du langage
Authors: Guidetti Michèle , Morgenstern Aliyah 
Published: September 2017

L'objectif de ce numéro spécial est de présenter et de poursuivre les discussions et les échanges de points de vue à la fois théoriques et méthodologiques amorcés lors de l'atelier du GDR ADYLOC (GDR CNRS 3195) sur les liens entre gestes et signes qui s’est tenu à Paris les 4 et 5 Avril 2014. Ce Groupe de Recherche « Langues, langage oral et cognition : acquisition et dysfonctionnements » a rassemblé à l’initiative et autour de Maya Hickmann entre 2009 et 2015 bon nombre de spécialistes français de ces questions. Il a constitué un lieu propice aux discussions et échanges scientifiques permettant de faire émerger de nouveaux questionnements, perspectives et projets de recherche.
Night-exposure to noise induces hearing loss more than day exposure
Authors: Tharwat Adel , Abo El-Naga Heba Abd El-Rehem , Zien Ahmed Mahmoud , Abdel-Wahab Yasmien , Sanyelbhaa Hossam 
Published: September 2017

Objective:
It was reported that exposure to high noise levels at night would induce more hearing loss in mice than exposure in the day. The present study aims to test this finding in human.

Materials and methods:
Eighty-four subjects were included in this study. They were males, working at textile factories. According to the type of working shifts of the workers, the study group was subdivided into two equal groups; (i) Day group: including those who worked only in day shifts through all of their employment, (ii) Day and night group: including those who worked in alternating shifts; day shift for a week followed by night shift for another week.

Results:
The day and night group had significantly higher (worse) thresholds at frequencies 3, 4, 6 kHz. Fourteen subjects (17%) in the present study had bilateral normal hearing sensitivity; 12 subjects (14%) in the day group and 2 subjects (2%) in the Day and night group.

Conclusions:
Alternating night and day noise exposure proved to be more insulting to the cochlea and resulted in a more pronounced hearing loss when compared to day only-noise exposure.
Key comparison BIPM.RI(I)-K3 of the air-kerma standards of the NIM, China and the BIPM in medium-energy x-rays
Authors: Burns D T , Kessler C , Jinjie Wu , Peiwei Wang 
Published: September 2017

A key comparison has been made between the air-kerma standards of the NIM, Republic of China and the BIPM in the medium-energy x ray range. The results show the standards to be in agreement at around the level of the expanded uncertainty (k = 2) of the comparison of 6.0 parts in 103. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
The systematic analysis of ultraconserved genomic regions in the budding yeast
Authors: Yang Zhi-Kai , Gao Feng 
Published: September 2017

Abstract

Motivation
In the evolution of species, a kind of special sequences, termed ultraconserved sequences (UCSs), have been inherited without any change, which strongly suggests those sequences should be crucial for the species to survive or adapt to the environment. However, the UCSs are still regarded as mysterious genetic sequences so far. Here, we present a systematic study of ultraconserved genomic regions in the budding yeast based on the publicly available genome sequences, in order to reveal their relationship with the adaptability or fitness advantages of the budding yeast.

Results
Our results indicate that, in addition to some fundamental biological functions, the UCSs play an important role in the adaptation of Saccharomyces cerevisiae to the acidic environment, which is backed up by the previous observation. Besides that, we also find the highly unchanged genes are enriched in some other pathways, such as the nutrient-sensitive signaling pathway. To facilitate the investigation of unique UCSs, the UCSC Genome Browser was utilized to visualize the chromosomal position and related annotations of UCSs in S.cerevisiae genome.

Availability and implementation
For more details on UCSs, please refer to the Supplementary information online, and the custom code is available on request.

Supplementary information
Supplementary data are available at Bioinformatics online.
Fast, robust and non-convex subspace recovery
Authors: Lerman Gilad , Maunu Tyler 
Published: September 2017

AbstractThis work presents a fast and non-convex algorithm for robust subspace recovery. The datasets considered include inliers drawn around a low-dimensional subspace of a higher dimensional ambient space and a possibly large portion of outliers that do not lie nearby this subspace. The proposed algorithm, which we refer to as fast median subspace (FMS), is designed to robustly determine the underlying subspace of such datasets, while having lower computational complexity than existing accurate methods. We prove convergence of the FMS iterates to a stationary point. Further, under two special models of data, FMS converges to a point which is near to the global minimum with overwhelming probability. Under these models, we show that the iteration complexity is globally sublinear and locally $r$-linear. For one of the models, these results hold for any fixed fraction of outliers (&lt; 1). Numerical experiments on synthetic and real data demonstrate its competitive speed and accuracy.
Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease
Authors: Zimmerman Ofer , Rösler Berenice , Zerbe Christa S , Rosen Lindsey B , Hsu Amy P , Uzel Gulbu , Freeman Alexandra F , Sampaio Elizabeth P , Rosenzweig Sergio D , Kuehn Hye Sun , Kim Tiffany , Brooks Kristina M , Kumar Parag , Wang Xiaowen , Netea Mihai G , van de Veerdonk Frank L , Holland Steven M 
Published: September 2017

Abstract
Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.
Nodular Vasculitis in a Patient With Crohn's Disease on Vedolizumab
Authors: Pouldar Delila , Elsensohn Ashley , Ortenzio Francesca , Shiu Jessica , McLeod Michael , de Feraudy Sébastien 
Published: September 2017

Abstract:
Erythema induratum (EI), or nodular vasculitis (NV), is a type of panniculitis that is often associated with vasculitis affecting various-sized veins, venules, and arteries in reaction to various causative factors. Historically, EI was highly linked to tuberculosis, but in 1946, Montgomery first proposed the term NV to describe cases of EI not associated with tuberculosis. Only 2 reports of NV associated with inflammatory bowel disease have been reported in the literature. The authors report a 60-year-old woman with Crohn's disease presenting with exacerbation of NV in the setting of vedolizumab therapy.
Body iodine status in women with postmenopausal osteoporosis
Authors: Arslanca Tufan , Korkmaz Vakkas , Arslanca Seyma B. , Karadag Burak , Ergün Yusuf 
Published: September 2017

Abstract

Objective:
Postmenopausal osteoporosis is a frequent cause of morbidity and can negatively impact life expectancy; iodine is an essential element for bone mineralization, and iodine deficiency is frequently observed. The aim of the present study was to understand the connection between postmenopausal osteoporosis and the level of iodine in the body.

Methods:
A total of 132 participants were divided into three groups: group 1 consisted of healthy postmenopausal women (n = 34), group 2 comprised osteopenic women (n = 38), and group 3 included women with postmenopausal osteoporosis (n = 60). The three groups were compared according to demographic, clinical, and laboratory findings.

Results:
The urinary iodine levels were recorded as 216.1 ± 125.2 in the control group, 154.6 ± 76.6 in the osteopenic group, and 137.5 ± 64.9 in the postmenopausal osteoporosis group (P < 0.001). These differences were maintained after adjustment for body mass index (P < 0.001). The urinary iodine level accurately correlated with the total T-score for the lumbar spine (r = 0.236, P = 0.008). Multiple regression analysis showed that corrected for body mass index, alkaline phosphatase isoenzyme, and urinary deoxypyridinoline, the urinary iodine level was significantly associated with total T-score (beta coefficient = 0.270, P = 0.006).

Conclusions:
The urinary iodine level was significantly lower in women with postmenopausal osteoporosis, and iodine replacement may be important in preventing osteoporosis in areas where iodine deficiency is endemic.
Visualization of Skin Perfusion by Indocyanine Green Fluorescence Angiography—A Feasibility Study
Authors: Steinbacher Johannes , Yoshimatsu Hidehiko , Meng Stefan , Hamscha Ulrike M. , Chan Chun-Sheng , Weninger Wolfgang J. , Wu Chieh-Tsai , Cheng Ming-Huei , Tzou Chieh-Han John 
Published: September 2017

Summary:
Plastic and reconstructive surgery relies on the knowledge of angiosomes in the raising of microsurgical flaps. Growing interest in muscle-sparing perforator flaps calls for reliable methods to assess the clinical feasibility of new donor sites in anatomical studies. Several injection techniques are known for the evaluation of vascular territories. Indocyanine green–based fluorescence angiography has found wide application in the clinical assessment of tissue perfusion. In this article, the use of indocyanine green–based fluorescence angiography for the assessment of perforasomes in anatomical studies is described for the first time.
Scar Tissue Causing Saphenous Nerve Entrapment: Percutaneous Scar Release and Fat Grafting
Authors: Ulloa Martin , Coronel Banda Mauricio 
Published: September 2017

Summary:
Painful neuropathies can be caused by nerve compression or neuromas. Nerve compressions can arise from scar adhesions causing painful posttraumatic entrapment of nerve branches via fibrosis. The classical treatment methods include neurolysis and nerve transposition. In this case, we present the treatment of recurrent scar entrapment of the saphenous nerve with percutaneous neurolysis and lipofilling in a patient who had previously undergone an open neurolysis procedure. Resolution of the condition without any complications was noted during the 2-month clinical follow-up. Percutaneous neurolysis and lipofilling are shown to be safe and reproducible methods for the treatment of neuropathic compressive scars.
Hyperbaric Oxygen Inhibits Reperfusion-Induced Neutrophil Polarization and Adhesion Via Plasmin-Mediated VEGF Release
Authors: Francis Ashish , Kleban Shawna R. , Stephenson Linda L. , Murphy Patrick S. , Letourneau Peter R. , Fang Xin-Hua , Wang Wei Z. , Baynosa Richard C. 
Published: September 2017

Background:
Ischemia-reperfusion (IR) injury is seen in many settings such as free flap salvage and limb replantation/revascularization. The consequences—partial/total flap loss, functional muscle loss, or amputation—can be devastating. Of the treatment options available for IR injury, hyperbaric oxygen (HBO) is the most beneficial. HBO inhibits neutrophil-endothelial adhesion through interference of CD18 neutrophil polarization in IR, a process mediated by nitric oxide. The purposes of this study were to examine the involvement of vascular endothelial growth factor (VEGF) in the beneficial HBO effect on CD18 polarization and neutrophil adhesion and investigate the effect of plasmin on VEGF expression in skeletal muscle following IR injury.

Methods:
A rat gracilis muscle model of IR injury was used to evaluate the effect of VEGF in IR, with and without HBO, on neutrophil CD18 polarization and adhesion in vivo and ex vivo. Furthermore, we investigated the effects that plasmin has on VEGF expression in gracilis muscle and pulmonary tissue by blocking its activation with alpha-2-antiplasmin.

Results:
HBO treatment following IR injury significantly decreased neutrophil polarization and adhesion ex vivo compared with the IR group. Anti-VEGF reversed the beneficial HBO effect after IR with polarization and adhesion. In vivo adhesion was also increased by anti-VEGF. HBO treatment of IR significantly increased the VEGF protein in both gracilis and pulmonary vasculature. Alpha-2-antiplasmin significantly reversed the HBO-induced increase of VEGF in gracilis muscle.

Conclusions:
These results suggest that HBO inhibits CD18 polarization and neutrophil adhesion in IR injury through a VEGF-mediated pathway involving the extracellular matrix plasminogen system.
Guideline-recommended vs high-dose long-term opioid therapy for chronic noncancer pain is associated with better health outcomes: data from a representative sample of the German population
Authors: Häuser Winfried , Schubert Tino , Scherbaum Norbert , Tölle Thomas 
Published: September 2017

Abstract
Recent evidence-based guidelines for long-term opioid therapy (LTOT) for chronic noncancer pain (CNCP) have defined daily morphine equivalent doses (MEQ/d) that require particular caution. The recommendation for a threshold MEQ/d is based on North American studies that have demonstrated negative health outcomes associated with high-dose LTOT for CNCP. We have conducted a retrospective cross-sectional study using an anonymized German health claims database, including 4,028,618 persons insured by 69 German statutory health insurances, representative of age and sex for the German population in 2014. Those receiving German guideline-recommended opioid treatments (dose <120 mg MEQ/d) for CNCP were compared with those receiving high-dose LTOT (≥120 mg MEQ/d) for selected health outcomes (risky opioid prescribing; hospital admissions due to diagnoses indicative of abuse/addiction of prescribed opioids; and health costs). The prevalence of LTOT for CNCP was 0.8%, with 9.9% receiving high-dose LTOT. Those receiving German guideline-recommended opioid treatments vs those receiving high-dose LTOT differed for the following parameters: risky opioid prescribing (combination with tranquilizers) (11.1% vs 14.3%; P < 0.001), hospital admissions because of mental and behavioral disorders due to alcohol, opioids, tranquilizers, multiple substances and intoxication by narcotic agents (1.6% vs 2.9%; P < 0.001), and total health costs (7259 vs 10,732 Euro; P < 0.001). The difference in annual costs between the 2 groups was largely due to differences in pharmaceutical costs in the outpatient setting (2282 vs 5402 €; P < 0.001). These data confirm recommendations for a threshold MEQ/d for CNCP as recommended by recent opioid prescribing guidelines for CNCP.
Digital Colposcopy With Dynamic Spectral Imaging for Detection of Cervical Intraepithelial Neoplasia 2+ in Low-Grade Referrals: The IMPROVE-COLPO Study
Authors: Cholkeri-Singh Aarathi , Lavin Philip T. , Olson Christopher G. , Papagiannakis Emmanouil , Weinberg Lori 
Published: September 2017

Objective
The aim of the study was to determine, in a wide “real-world” setting, whether digital colposcopy with adjunctive dynamic spectral imaging (DSI) mapping increases the detection of women with high-grade cervical intraepithelial neoplasia (CIN).

Materials and Methods
A multicenter, two-arm, observational, cross-sectional study that recruited women 21 years and older, having colposcopy after a low-grade abnormality screening result. The prospective arm collected outcomes of digital colposcopy with DSI used for identifying biopsy sites at the colposcopists' discretion. The retrospective control arm (number of subjects matched 1:1 per colposcopist) collected outcomes of standard colposcopy. The primary outcome was histopathological detection of women with CIN 2+ by colposcopic biopsy.

Results
The study included 1,788 women in the retrospective and 1,857 in the prospective arm from 39 US community-based clinics. Subject characteristics were comparable. A total of 71.6% of the women in the retrospective and 71.5% in the prospective arm underwent biopsy. The average number of biopsies increased from 1.032 (retrospective) to 1.256 (prospective). The yield of CIN 2+ patients was 7.21% in the retrospective and 9.48% in the prospective arm, a 2.27% difference (95% confidence interval = 0.47%–4.07%, p = .014) and 31.4% relative increase. The yield of CIN 3+ patients was 2.07% in the retrospective and 3.23% in the prospective arm, a 1.16% (95% confidence interval = 0.12%–2.24%, p = .031) absolute difference and 56.1% relative increase. The false-positive rates for biopsied patients were comparable (64.43% vs 62.04%, p = .139).

Conclusions
Digital colposcopy with the adjunctive DSI increased CIN 2+ and CIN 3+ detection in low-grade referrals compared with standard colposcopy, with a similar number of women undergoing biopsy.
Acute Opiate Overdose: An Update on Management Strategies in Emergency Department and Critical Care Unit
Authors: Parthvi Rukma , Agrawal Abhinav , Khanijo Sameer , Tsegaye Adey , Talwar Arunabh 
Published: September 2017

Background:
Opioids are natural, semisynthetic, or synthetic substances that act on opioid receptors in the central nervous system. Clinically, they are prescribed for pain management. Opioid overdose (OOD) occurs when the central nervous system and respiratory drive are suppressed because of excessive consumption of the drug. Symptoms of OOD include drowsiness, slow breathing, pinpoint pupils, cyanosis, loss of consciousness, and death. Due to their addictive potential and easy accessibility opioid addiction is a growing problem worldwide. Emergency medical services and the emergency department often perform initial management of OOD. Thereafter, some patients require intensive care management because of respiratory failure, metabolic encephalopathy, acute kidney injury, and other organ failure.

Areas of Uncertainty:
We sought to review the literature and present the most up-to-date treatment strategies of patients with acute OOD requiring critical care management.

Data Sources:
A PubMed search was conducted to review all articles between 1950 and 2017 and the relevant articles were cited.

Results & Conclusions:
Worldwide, approximately 69,000 people die of OOD each year, and approximately 15 million people have opioid addiction. In the United States, death from OOD has increased almost 5-fold from 2001 to 2013. OOD leading to intensive care unit admission has increased by 50% from 2009 to 2015. At the same time, the mortality associated with these admissions has doubled. The management strategies include airway management, use of reversal agents, assessing and treating coingestions and associated complications, treatment of opioid withdrawal with alpha-agonists, and psychosocial support to help with opiate addiction and withdrawal. This warrants awareness among clinicians regarding the adverse effects associated with opioid use, management strategies, and calls for a multidisciplinary approach to treating these patients.
Parental Distress and Quality of Life in Pediatric Inflammatory Bowel Disease
Authors: Diederen Kay , Haverman Lotte , Grootenhuis Martha A. , Benninga Marc A. , Kindermann Angelika 
Published: September 2017

ABSTRACTObjectives:The interrelation between the course of inflammatory bowel disease (IBD) in children and parent's distress, and the subsequent impact this may have on health‐related quality of life (HRQOL) of the child is unclear. Therefore, we investigated patient's HRQOL and parental distress and the association between the course of IBD, parental distress, and HRQOL of pediatric patients with IBD.Methods:Pediatric patients with IBD (8–18 years) and parents were invited. Patients completed the Pediatric Quality of Life Inventory, and parents the Distress Thermometer for Parents, simultaneously. Disease course was expressed as current clinical disease activity or months since last IBD flare. Patient's HRQOL and parental distress were compared to healthy controls.Results:In total, 87 patients (71% response rate, 59% boys, median age 15.2 years) and parents were included. Patients had an impaired total HRQOL (β = 0.125, P = 0.010), driven by lower physical (0.196, P = 0.001) and school (β = 0.232, P < 0.001) functioning. Parents of children with IBD exhibited comparable levels of distress to parents of healthy children on the total problem and most subdomain problem scores (practical, social, emotional, physical, and cognitive), yet experienced more frequent parenting problems (P = 0.025). More severe disease course (months since last IBD flare) was indirectly associated, through parental distress, with decreased HRQOL of patients.Conclusions:Worse disease course is directly associated with increased distress of parents and indirectly with lower HRQOL of children and adolescents with IBD. Distress of parents may be considered in management of pediatric IBD to improve HRQOL of children.