bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ammonium fluoride-catalyzed sol-gel route applied for curcumin-based pH sensors
Authors: Kazmirczak Paula C. , Cichero Matheus C. , Santos Joao Henrique Zimnoch Dos 
Published: September 2024

Abstract

Curcumin has potential application as a colorimetric sensor and can be used, for example, to monitor the freshness of foods, although some of its physicochemical properties, such as solubility and stability, limit its use. In the present work, a natural curcumin extract was incorporated into organic‒inorganic hybrid silica matrices produced by the sol-gel method using ammonium fluoride as the main catalyst. A series of pH sensors based on the encapsulation of curcumin were prepared using a series of organosilanes (methytriethoxysilane, octyltriethoxysilane, octadecyltrimethoxysilane and 3-(aminopropyltriethoxysilane)) and were used in the synthesis of hybrid silicas. The effectiveness of the employed sol-gel route and the properties of the encapsulated materials were evaluated by a set of complementary analytical techniques, namely, infrared spectroscopy, 29Si solid-state nuclear magnetic resonance spectroscopy, nitrogen porosimetry, dynamic light scattering, confocal laser scanning microscopy and diffuse reflectance UV‒Vis spectroscopy. The immobilization of compounds in a solid matrix can cause a shift in the maximum absorption bands in the ultraviolet‒visible region as a result of interactions between the organic molecules and the solid support. The incorporation of curcumin into different silica matrices improved the performance of the sensors to up to 3.5 times greater than that obtained by the free compound when interacting with ammonia vapor.
Leveraging Social Media for Public Health: NLP Implementations for Blood Donation Data Analysis in Japan
Authors: Espinoza Roberto , Kishimoto Kazumasa , Liu Chang , Santos Luciano H.O. , Mori Yukiko , Yamamoto Goshiro , Kuroda Tomohiro 
Published: September 2024

Abstract

Background:: Blood donation is crucial for healthcare systems, yet maintaining an adequate supply is a persistent challenge. Traditional methods to understand public sentiment and donor behavior are often limited. Social media, particularly Twitter, offers a promising alternative for real-time insights. This study explores the viability of using Twitter data to analyze blood donation sentiment in Japan, considering the evolving perspectives of younger generations.
Methods:: We replicated previous study results using the Tohoku BERT model and tested a refined Blood Donation Tweets for User Classification (BDT-UC) dataset and another customized version of the model for better classification. We also compared various topic modeling methods, including Latent Dirichlet Allocation (LDA), Non-Negative Matrix Factorization (NMF), and BERT-based models, using two different preprocessing techniques. Finally, we integrated the classification into the Topic Modeling analysis for a final evaluation.
Results:: Our findings indicate that although the refined dataset has an overall lower classification performance, it improved the implementation results, ensuring more balanced labeling across the data. Our refined model had a small reduction in overall precision (from 78.4% in the best evaluated model to 75.8% in the refined model). However, we improved the implementation results, ensuring more balanced labeling across the data. For topic modeling, BERT-based topic models, particularly those preprocessed with the MeCab library, achieved higher coherence and diversity scores than traditional methods. Additionally, there were significant differences when the dataset was processed by user category, with increased coherence and diversity for the undetermined one but notably lower coherence values for the other categories.
Conclusion:: This study underscores the significance of initial classification and preprocessing for effective topic modeling, which impacts the viability of extracting insights from Japanese social media data. The developed methodologies could support more effective analysis of blood donation groups, and better targeted donation campaigns.
A myelinic channel system for motor-driven organelle transport
Authors: Edgar Julia , Chapple Katie , Green Tabitha , Chen Yihsin , Wirth Sarah , Gerwig Ulrike , Aicher Marie Louise , Kim Yeonsu , Brown Angus , Pardo-Fernandez Luis , Crawford Colin , Smith Rebecca Sherrard , McHugh Rebecca , Kassmann Celia , Komarek Lina , Werner Hauke , Kneussel Matthias , Brown Euan , Goebbels Sandra , Nave Klaus-Armin , Lee Jeffrey , Davis Ilan 
Published: September 2024

Abstract

Myelin sheaths comprise compacted layers of oligodendroglial membrane wrapped spirally around axons. Each sheath, if imagined unwrapped, has a cytoplasm-filled space at its perimeter, linking it to the oligodendrocyte soma via a short process. By electron microscopy (EM), this space, which we term the ‘myelinic channel system’ contains microtubules and membranous organelles, but whether these are remnants of development or serve a function is unknown. Performing live imaging of myelinating oligodendrocytes expressing fluorescent reporters, we found that the myelinic channel system serves microtubule-dependent organelle transport. Further, the intra-myelinic movement of peroxisomes was modulated by neuronal electrical activity in these mixed neural cell cultures. Loss of oligodendroglial Kif21b or CNP in vivo led to apparent stasis of myelin organelles and secondary axon pathology. This suggests that oligodendrocytes require motor transport in myelin to maintain axonal integrity.
Whole-Genome analyses of 1,364 breast cancers with clinical records
Authors: Ju Young Seok , Kim Ryul , Yu Jonghan , Lim Joonoh , Oh Baek-Lok , Nam Seok Jin , Kim Seok Won , Lee Jeong Eon , Chae Byung Joo , Kim Ji-Yeon , Park Ga Eun , Kang Bong Joo , Baek Pil Sun , Bae Soo Yeon , Yoon Chang Ik , Lee Young Joo , Kim Dooreh , Shin Kabsoo , Lee Ji Eun , Kang Jun , Lee Ahwon , Connolly-Strong Erin , Lee Sangmoon , Lee Bo Rahm , Lee Yuna , Yi Ki Jong , Kwon Young Oh , Chun In Hwan , Park Junggil , Kim Jihye , Choi Chahyun , Shin Jong Yeon , Lee Hyunjung , Kim Minji , Park Hansol , Jeong Ilecheon , Yi Boram , Lee Won-Chul , Lee Jeong Seok , Park Woo Chan , Kim Sung Hun , Choi Yoon-La , Lee Jeongmin , Park Yeon Hee 
Published: September 2024

Abstract

Recent advancements in genomic technologies have become critical tools for deciphering the genetic complexities of cancer tissues, enabling precision medicine strategies aimed at improving patient clinical outcomes. Here we performed a comprehensive analysis of clinically annotated whole genome and whole transcriptome sequences from 1,364 breast cancer cases. Our investigation provides the most detailed genomic landscapes of breast cancer to date, which allowed us to comprehensively correlate genomic changes with clinical characteristics. Our findings include, but not limited to, (1) whole-genome-based homologous recombination deficiency profiles effectively predict responses to adjuvant chemotherapy and first-line CDK4/6 inhibitor treatment, (2) focal ERBB2 amplifications, often arising via extrachromosomal DNA mechanisms, are strongly associated with a positive response to neoadjuvant chemotherapy. Additionally, our study identified (3) recurrent copy number amplifications linked to patient survival, and (4) whole-genome-based intratumoral heterogeneity profiles that can predict patient survival as well as response to anti-HER2 therapies. Our work underscores the power of highly-annotated whole-genome and transcriptome sequencing of a population-scale cancer cohorts for uncovering clinically relevant genomic mutations and novel molecular targets, thereby advancing precision oncology strategies for breast cancer.
Induction of liquid bacterial and solid fungal cultures by conductive electrostimulation
Authors: Kambouris Manousos , Spanou Grigoria , Kritikou Stavroula , Milioni Afroditi , Stathoulias Andreas , Goudoudaki Stavroula , Manoussopoulos Yiannis , Karamperis Kariofyllis , Velegraki Aristea , Patrinos George , Giavasis Ioannis 
Published: September 2024

Abstract

When testing cultures of microorganisms under electrostimulation to explore antimicrobial use for therapy and pasteurization, small, diverse windows of stimulative effects have been noticed. This work strives to explore possible stimulative effects of conductive electrostimulation with alternating current on fungi and bacteria as a proof-of-principle applicable to production of biomass, probiotics, biopharmaceuticals, bacteriotherapeutics, metabolites and other bioproducts or bioprossesses. To do so an iontophoresis device was applied in solid fungal cultures and presentation of mycelial diameter compared to control dishes in growth-time curves; and in liquid bacterial cultures without or with simultaneous or consecutive pasteurization and estimation of the colony forming units after a set time, in comparison with proper controls. Six fungi belonging in four divisions showed conditional stimulative effects when tested in solid cultures. Six bacteria in respective liquid cultures and of different shapes and Gram status also showed, under different conditions, stimulative effects with Electrostimulation if treated solely and alleviating effects if co-treated with mild heat pasteurization protocols. There is no uniform set of parameters for stimulative results of electrostimulation; though it seems that some nutrient substrates are more supportive to stimulative effects compared to others.
Hexanitrogen (N6): A Synthetic Leap Towards Neutral Nitrogen Allotropes
Authors: Schreiner Peter , Qian Weiyu , Mardyukov Artur 
Published: September 2024

Abstract

As the availability of renewable energy varies drastically over space and time, energy storage is a prime challenge for humankind. Current strategies include battery systems or high-energy molecules including hydrogen or ammonia for chemical energy storage. Compounds consisting only of the element nitrogen (polynitrogens or nitrogen allotropes), are deemed the cleanest and ideal energy storage materials due to their immense energy content (about five times higher than hydrogen) and because they release only harmless nitrogen (N₂) upon decomposition1. However, their extreme instability poses a significant synthetic challenge and no neutral molecular nitrogen allotrope beyond N2 has been isolated2,3. Here, we present the room temperature preparation of molecular N6 (hexanitrogen) through the gas-phase reaction of chlorine or bromine with silver azide, followed by trapping in argon matrices at 10 K. We also prepared neat N6 as a film at liquid nitrogen temperature (77 K), indicating its unexpectedly high stability (at a temperature that can be handled well) and the scalability of the synthesis. Infrared and ultraviolet spectroscopy, heavy isotope 15N labelling experiments, and ab initio computations firmly support our findings. The preparation of a metastable nitrogen allotrope beyond N₂ opens new vistas for the development of highly sought-after high-energy materials.
Abnormally Low HbA1c Caused by Hemolytic Anemia, A Case Report and literature review
Authors: Bakhtiari Sajjad , Timbrell Nathan E. , D’Almeida Sènan M. 
Published: September 2024

Abstract

Hemoglobin A1c is a widely used diagnostic tool for monitoring glycemic control in diabetes management. However, its accuracy can be influenced by various factors. We present a case of a 17-year-old boy with abnormally low Hemoglobin A1c levels caused by warm autoantibody-induced hemolytic anemia. This case highlights the importance of considering conditions that may affect erythrocyte survival, and the potential interferences when interpreting Hemoglobin A1c results to ensure accurate diagnosis and effective management of diabetes.
INCLUSÃO DA DIMENSÃO AFETIVA NO PROJETO ARQUITETÔNICO
Authors: Imara Duarte  , D. L. Costa Angelina , S. G. Acioly Angélica , M. Tonetto Leandro 
Published: September 2024

Sendo compreendido de modo geral, como algo vago e subjetivo, ligado diretamente às emoções humanas, a dimensão afetiva é mais palpável do que aparenta. Ela tem recebido recentemente certa atenção em função de suas implicações e aplicabilidade em investigações qualitativas, mais especificamente no discurso arquitetônico, em função do impacto do ambiente construído sobre as pessoas. Nesse sentido, a análise dos projetistas e dos seus modos de apropriação do arcabouço fornecido justifica-se à medida que poderá auxiliar a identificar, no plano da práxis, os melhores procedimentos e abordagens, as estratégias, para salvaguarda não só de princípios de usabilidade ou conforto, como também os princípios valorais e afetivos do utilizador. Desse modo, o objetivo geral do trabalho foi avaliar a apropriação do arcabouço e ferramental específicos do conjunto teórico-metodológico original denominado ‘Projeto Sensível ao Valor centrado no Afeto’ (PSV_A), por parte dos projetistas, em ambiente acadêmico. O método foi constituído do repasse do arcabouço teórico-metodológico proposto às turmas de graduação e pós-graduação em Arquitetura e Urbanismo, e o acompanhamento dos modos e interação, variações e apropriações pelas quais os discentes o puseram em prática, tendo como estudo de caso o ambiente hospitalar, sob uma avaliação composta por análise comparativa, conceitual conforme aproximação ao referido arcabouço e, análise de conteúdo. O trabalho busca contribuir para o debate acerca da consideração dos valores, princípios e ética dos usuários e demais partes interessadas no planejamento de elementos societais influenciados pelo projeto arquitetônico de ambientes de saúde.
FACTORS AFFECTING THE CHOICE OF ADAPTATION STRATEGIES TO CLIMATE EXTREMES: THE CASE OF SMALLHOLDER FARMERS IN SOUTHERN ZAMBIA
Authors: Sichoongwe Kiru , Wang Jinxia 
Published: September 2024

This study assesses smallholder farmers' adaptation to climate extremes and its contributing factors in Zambia's southern province. The study employed primary data from 270 smallholder farmers, constituting the sample size. According to the study's findings, change crop variety was adopted by 43% of the farmers. Other strategies of adaptation that were employed include; agricultural insurance, change sow/harvest date, crop diversification and soil conservation. The findings also showed that the various adaptation strategies (agricultural insurance, change sow/harvest date, crop diversification and soil conservation), correlated positively with age, education, distance, farming experience, radio ownership, an ox, a plough, and extension source. The study makes the following recommendations; (a) enhancing the education and awareness level of farmers towards climate extreme, (b) when drafting policy, asset formation should be considered, and (c) when developing and implementing adaptation strategies, indigenous knowledge should be taken into account.
CAN THE SMALL-SCALE PRODUCERS OF NAVEL ORANGE RESIST THE STABILITY OF THE FARM GATE PRICES AND THE SOAR OF THE INPUT PRICES WITHIN THE BIOPHYSICAL FACTORS?
Authors: Mohamed Assem A. A. , Esmail A. A. M. , Abdelaty Emad F. 
Published: September 2024

Egypt Navel orange planted area reached about 174.6 thousand acres during the average period of 2012-2020. Delta governorates is the major orange’s productive region in Egypt with 97.4% of the total production of the country. 87.2% of orange’s planted area came from only five Delta governorates. The top planted area governorates are El Behera with an acreage area representing about (41.3%), followed by Qalyoubia (16.7%), Ismailia (11.1%), Menufia (9.54%) and Sharqiya (8.52%) of total planted areas during the period 2012-2020. El-Behera is the major Navel orange’s productive governorate in Egypt with (43.9%) of Egyptian total production of Navel orange, followed by Qalyoubia (18.8%), Menufia (9.2%), Ismailia (8.3) and Sharqiya (7.7%) of Navel orange total production during the period 2012-2020. In recent years, small scale farmers have experienced technical, environmental and economic problems. This study will shade light on the economic problems because fruit prices have come to a standstill or even decreased while the production costs have risen continuously. The present study depends on data collected from the private small farm planted with Washington Navel orange trees [Citrus sinensis L.(Osbeck)] since 1968, which is located in Minyat as Siba, Benha-Qalyoubia governorate, Egypt. The result shows that the average values of fertilizers, pests and diseases account for a large proportion of the total costs, representing about 42.57% and 26.47% respectively from the total production costs during 2012-2022. Prices received for Navel oranges fluctuate markedly from year to year. This combined with fluctuations in yields. Over the period 2012 to 2022 farm gate prices of Navel orange averaged 2905 Egyptian pound (LE) per ton, with the minimum of LE 1750 per ton in 2012 and the maximum of LE 4000 per ton in the 2019, 2020 and 2021.
ANALYSIS OF THE FEASIBILITY STUDY OF THE DOMESTIC WASTE BUSINESS IN SIDENRENG RAPPANG DISTRICT DUCK BONE FLOUR (DUCK BONE FLOUR)
Authors: Haryono Iranita 
Published: September 2024

Duck bone waste which is a domestic waste in Sidenreng Rappang Regency has not been utilized and there is no handler which is feared will pollute the environment. So it is necessary to use it by making it economically valuable by making duck bone flour. The purpose of this study was to analyze the feasibility of investing in duck bone waste (Duck Bone Flour). The method used is a saturated sample where all of the population is a sample because the number of samples is limited. Methods of data analysis using financial analysis. The analytical tool used for the financial aspect uses analysis of the Payback Period (PP), Net Present Value (NPV), Internal Rate of Return (IRR), and Profitability Index (PI), to determine whether a business is feasible or not. The results showed that the Duckbone Flour Business, from a financial point of view, with a project duration of 10 years and a discount rate of 10%, it proved feasible. An analysis of admission criteria found a payback period (PP) of 6 months and 1 week. Net Present Value (NPV) is IDR 1,730,085,150, Profitability Index (PI) is 1.63% and Internal Rate of Return (IRR) is 32%. This research is important to be carried out as a source of information for the community and the government about the economic value of duck bone waste.
Implementation of Self-Acceptance in the PukPuk Station Mental Health Community Support Group through Group Communication
Authors: Sabrina Eya Rusydasani , Suminar Jenny Ratna , Damayanti Trie 
Published: September 2024

This research aims to explore the implementation of self-acceptance in support group in the PukPuk Station mental health community through a group communication approach. It has relation that mental health is an important variable in improving individual well-being and health. The research method used was qualitative with a phenomenological design. Data was collected through participant observation, in-depth interviews with group members, and document analysis of group meeting notes. This research uses some theory concept such as group communication, mental health, self-acceptance. Research findings show that through structured and open group communication, support group members are able to increase their level of self-acceptance. Factors such as social support, mutual identification, and social learning also play an important role in the process of self-acceptance. The open, deep, and structured communication creates a safe environment for members to strengthen their self-acceptance. Then, about the practical of this research are importance of strengthening group communication skills in the training and development of support group members, as well as expanding access to community programs that emphasize the importance of self-acceptance. The implication of this research is the importance of strengthening group communication in supporting individual self-acceptance processes in the context of the mental health community Keywords: self-acceptance, support group, group communication
Usability, Engagement, and Report Usefulness of Chatbot-Based Family Health History Data Collection: Mixed Methods Analysis
Authors: Nguyen Michelle Hoang , Sedoc João , Taylor Casey Overby 
Published: September 2024

Background
Family health history (FHx) is an important predictor of a person’s genetic risk but is not collected by many adults in the United States.

Objective
This study aims to test and compare the usability, engagement, and report usefulness of 2 web-based methods to collect FHx.

Methods
This mixed methods study compared FHx data collection using a flow-based chatbot (KIT; the curious interactive test) and a form-based method. KIT’s design was optimized to reduce user burden. We recruited and randomized individuals from 2 crowdsourced platforms to 1 of the 2 FHx methods. All participants were asked to complete a questionnaire to assess the method’s usability, the usefulness of a report summarizing their experience, user-desired chatbot enhancements, and general user experience. Engagement was studied using log data collected by the methods. We used qualitative findings from analyzing free-text comments to supplement the primary quantitative results.

Results
Participants randomized to KIT reported higher usability than those randomized to the form, with a mean System Usability Scale score of 80.2 versus 61.9 (P<.001), respectively. The engagement analysis reflected design differences in the onboarding process. KIT users spent less time entering FHx information and reported more conditions than form users (mean 5.90 vs 7.97 min; P=.04; and mean 7.8 vs 10.1 conditions; P=.04). Both KIT and form users somewhat agreed that the report was useful (Likert scale ratings of 4.08 and 4.29, respectively). Among desired enhancements, personalization was the highest-rated feature (188/205, 91.7% rated medium- to high-priority). Qualitative analyses revealed positive and negative characteristics of both KIT and the form-based method. Among respondents randomized to KIT, most indicated it was easy to use and navigate and that they could respond to and understand user prompts. Negative comments addressed KIT’s personality, conversational pace, and ability to manage errors. For KIT and form respondents, qualitative results revealed common themes, including a desire for more information about conditions and a mutual appreciation for the multiple-choice button response format. Respondents also said they wanted to report health information beyond KIT’s prompts (eg, personal health history) and for KIT to provide more personalized responses.

Conclusions
We showed that KIT provided a usable way to collect FHx. We also identified design considerations to improve chatbot-based FHx data collection: First, the final report summarizing the FHx collection experience should be enhanced to provide more value for patients. Second, the onboarding chatbot prompt may impact data quality and should be carefully considered. Finally, we highlighted several areas that could be improved by moving from a flow-based chatbot to a large language model implementation strategy.