bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanomaterials‐based biosensors for detection of microorganisms and microbial toxins
Authors: Sutarlie Laura , Ow Sian Yang , Su Xiaodi 
Published: October 2016

AbstractDetection of microorganisms and microbial toxins is important for health and safety. Due to their unique physical and chemical properties, nanomaterials have been extensively used to develop biosensors for rapid detection of microorganisms with microbial cells and toxins as target analytes. In this paper, the design principles of nanomaterials‐based biosensors for four selected analyte categories (bacteria cells, toxins, mycotoxins, and protozoa cells), closely associated with the target analytes' properties is reviewed. Five signal transducing methods that are less equipment intensive (colorimetric, fluorimetric, surface enhanced Raman scattering, electrochemical, and magnetic relaxometry methods) is described and compared for their sensory performance (in term oflimit of detection, dynamic range, and response time) for all analyte categories. In the end, the suitability of these five sensing principles for on‐site or field applications is discussed. With a comprehensive coverage of nanomaterials, design principles, sensing principles, and assessment on the sensory performance and suitability for on‐site application, this review offers valuable insight and perspective for designing suitable nanomaterials‐based microorganism biosensors for a given application.
Intravascular and hybrid intraoperative stent placement for baffle obstruction in transposition of the great arteries after atrial switch
Authors: Poterucha Joseph T. , Taggart Nathaniel W. , Johnson Jonathan N. , Cannon Bryan C. , Cabalka Allison K. , Hagler Donald J. , Dearani Joseph A. , Cetta Frank 
Published: October 2016

ObjectivesTo report our experience with intravascular and hybrid intra‐operative stent placement for baffle obstruction in patients with complete transposition of the great arteries (TGA) after the atrial switch (Mustard/Senning) operation.BackgroundVenous baffle obstruction is a challenging complication after atrial switch operation in patients with TGA. Traditional treatment options include intravascular stenting or surgery.MethodsA retrospective analysis of Mayo Clinic's electronic medical record was completed to identify consecutive pediatric and adult patients with TGA after atrial switch who underwent baffle stent implantation from 1994 to 2015.ResultsOverall, 64 patients were referred for cardiac catheterization, in whom 47 (73%) were noted to have hemodynamic and angiographic evidence of baffle obstruction. A total of 20 patients mean age 33 (range: 8–46) years old underwent stent implantation of baffle stenosis at a mean of 33 (range: 7.5–45) years after initial atrial switch operation (Mustard, n = 19; Senning, n = 1). Overall, 27 baffles were stented in 20 patients via the following approaches: intravascular (17); hybrid surgical (3); staged intravascular & hybrid (2). Sites of stent placement were: superior vena cava (SVC) (13); inferior vena cava (IVC) (9); pulmonary venous baffle (5). Three patients had stent placement in the SVC and IVC baffles during the same procedure. Procedural adverse events occurred in 2/22 cases (9%) including creation of unintentional baffle leak (n = 1) and stent migration (n = 1). There was no procedure‐related mortality. At follow‐up (median 2, range 0.02–10 years), significantly improved NYHA class and mean Doppler baffle gradient were demonstrated (P < 0.05). Mild baffle re‐stenosis (mean Doppler gradient; 2–3 mmHg) occurred in two patients who have not required re‐intervention. Trivial baffle leak was noted in four patients. Baffle re‐intervention was only occurred in one patient. One patient with pre‐procedural Class IV symptoms died 3.5 months after stent implantation.ConclusionsThis study is the largest reported experience of intravascular and intra‐operative hybrid stent placement for patients with TGA after atrial switch. Transcatheter and minimally invasive hybrid intraoperative surgical stent placement are an effective strategy for relief of systemic and pulmonary venous baffle obstruction. © 2016 Wiley Periodicals, Inc.
Probe‐Molecule‐Assisted NMR Spectroscopy: A Comparison with Photoluminescence and Electron Paramagnetic Resonance Spectroscopy as a Characterization Tool in Facet‐Specific Photocatalysis
Authors: Peng Yung‐Kang , Fu Yingyi , Zhang Li , Teixeira Ivo F. , Ye Lin , He Heyong , Tsang Shik Chi Edman 
Published: October 2016

AbstractPhotoluminescence (PL) and EPR spectroscopy are the two most commonly used techniques to evaluate surface oxygen vacancies (VO surface) on photoactive transition metal oxides. However, these techniques have shortcomings in the characterization of facet‐dependent catalysis. Here, we used the chemical adsorption of a 31P‐containing probe molecule to obtain the distribution/concentration of VO surface as well as other surface features (hydroxyl groups) of ZnO by using 31P magic‐angle spinning NMR spectroscopy. This facet‐specific technique not only makes cross‐literature comparison feasible but also provides more comprehensive information to lead to a further understanding of the photocatalytic mechanism.
Site‐Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome
Authors: Kuan Seah Ling , Wang Tao , Weil Tanja 
Published: October 2016

AbstractThe synthetic transformation of polypeptides with molecular accuracy holds great promise for providing functional and structural diversity beyond the proteome. Consequently, the last decade has seen an exponential growth of site‐directed chemistry to install additional features into peptides and proteins even inside living cells. The disulfide rebridging strategy has emerged as a powerful tool for site‐selective modifications since most proteins contain disulfide bonds. In this Review, we present the chemical design, advantages and limitations of the disulfide rebridging reagents, while summarizing their relevance for synthetic customization of functional protein bioconjugates, as well as the resultant impact and advancement for biomedical applications.
AIM‐1: An Antibiotic‐Degrading Metallohydrolase That Displays Mechanistic Flexibility
Authors: Selleck Christopher , Larrabee James A. , Harmer Jeffrey , Guddat Luke W. , Mitić Nataša , Helweh Waleed , Ollis David L. , Craig Whitney R. , Tierney David L. , Monteiro Pedroso Marcelo , Schenk Gerhard 
Published: October 2016

AbstractAntibiotic resistance has emerged as a major threat to global health care. This is largely due to the fact that many pathogens have developed strategies to acquire resistance to antibiotics. Metallo‐β‐lactamases (MBL) have evolved to inactivate most of the commonly used β‐lactam antibiotics. AIM‐1 is one of only a few MBLs from the B3 subgroup that is encoded on a mobile genetic element in a major human pathogen. Here, its mechanism of action was characterised with a combination of spectroscopic and kinetic techniques and compared to that of other MBLs. Unlike other MBLs it appears that AIM‐1 has two avenues available for the turnover of the substrate nitrocefin, distinguished by the identity of the rate‐limiting step. This observation may be relevant with respect to inhibitor design for this group of enzymes as it demonstrates that at least some MBLs are very flexible in terms of interactions with substrates and possibly inhibitors.
Precision Construction of 2D Heteropore Covalent Organic Frameworks by a Multiple‐Linking‐Site Strategy
Authors: Qian Cheng , Xu Shun‐Qi , Jiang Guo‐Fang , Zhan Tian‐Guang , Zhao Xin 
Published: October 2016

AbstractIntegrating different kinds of pores into one covalent organic framework (COF) endows it with hierarchical porosity and thus generates a member of a new class of COFs, namely, heteropore COFs. Whereas the construction of COFs with homoporosity has already been well developed, the fabrication of heteropore COFs still faces great challenges. Although two strategies have recently been developed to successfully construct heteropore COFs from noncyclic building blocks, they suffer from the generation of COF isomers, which decreases the predictability and controllability of construction of this type of reticular materials. In this work, this drawback was overcome by a multiple‐linking‐site strategy that offers precision construction of heteropore COFs containing two kinds of hexagonal pores with different shapes and sizes. This strategy was developed by designing a building block in which double linking sites are introduced at each branch of a C3‐symmetric skeleton, the most widely used scaffold to construct COFs with homogeneous porosity. This design provides a general way to precisely construct heteropore COFs without formation of isomers. Furthermore, the as‐prepared heteropore COFs have hollow‐spherical morphology, which has rarely been observed for COFs, and an uncommon staggered AB stacking was observed for the layers of the 2D heteropore COFs.
Stabilizing Superacid Anions: The New [H(S4O13)2]3− Anion in the Crystal Structure of Li3[H(S4O13)2]
Authors: Schindler Lisa Verena , Becker Anna , Wickleder Mathias Siegfried 
Published: October 2016

AbstractThe unique hydrogenium‐bis‐tetrasulfate anion [H(S4O13)2]3− in the crystal structure of Li3[H(S4O13)2] (monoclinic, P21/n (No. 14), Z=2, a=552.46(4) pm, b=939.70(6) pm, c=1876.6(1) pm, β=97.492(3)°, V=965.9(1)⋅106 pm3) is the longest protonated polysulfate chain ever observed. Very strong symmetrical hydrogen bonds are a bold feature of the crystal structure. The protonation of a very weak base such as [S4O13]2− and accordingly the stabilization of the first base of the superacid H2S4O13 is a significant success towards the still elusive polysulfuric acids.
A Dendritic Supramolecular Complex as Uniform Hybrid Micelle with Dual Structure for Bimodal In Vivo Imaging
Authors: Zhang Simin , Zheng Yanmei , Yin Shengyan , Sun Jingzhi , Li Bao , Wu Lixin 
Published: October 2016

AbstractIn this study, a uniform complex dual micelle bearing a gadolinium‐substituted polyoxometalate core, a hydrophobic middle, and a biocompatible organic shell, which exhibits a uniform size and definite molecular weight and chemical composition, is constructed through a simple two‐step process for use as a fluorescence and magnetic resonance imaging (MRI) contrast agent. A paramagnetic polyoxometalate cluster, K13[Gd(β2‐SiW11O39)2], is first encapsulated with a cationic 3‐generation dendron (D‐3) bearing triethylene glycol monomethyl ether terminal groups through ionic substitution. The formed electrostatic complex, (D‐3)13[Gd(β2‐SiW11O39)2] (D‐GdSiW), which displays an ambivalent micellar structure, is then demonstrated to act as a suitable carrier for the uptake of cationic fluorescent dyes, forming a loaded complex. The dye‐loaded complex D‐GdSiW‐D is thus proven to display high relaxivity as a contrast agent, maintaining its structural stability under physiological conditions with low cell cytotoxicity. Confocal laser scanning microscopic observation also demonstrates the fluorescence imaging property of the prepared complex upon consumption by MCF‐7 cells. Both in vivo fluorescence imaging and MRI further confirm that the complex micelle with dual micellar structure may be a suitable liver‐specific contrast agent for clinical diagnosis.
Heterolytic (2 e) vs Homolytic (1 e) Oxidation Reactivity: N−H versus C−H Switch in the Oxidation of Lactams by Dioxirans
Authors: Annese Cosimo , D'Accolti Lucia , Fusco Caterina , Licini Giulia , Zonta Cristiano 
Published: October 2016

AbstractDioxiranes are powerful oxidants that can act via two different mechanisms: 1) homolytic (H abstraction and oxygen rebound) and 2) heterolytic (electrophilic oxidation). So far, it has been reported that the nature of the substrate dictates the reaction mode independently from the dioxirane employed. Herein, we report an unprecedented case in which the nature of the dioxirane rules the oxidation chemoselectivity. In particular, a switch from C−H to N−H oxidation is observed in the oxidation of lactams moving from dimethyl dioxirane (DDO) to methyl(trifluoromethyl)dioxirane (TFDO). A physical organic chemistry study, which combines the oxidation with two other dioxiranes methyl(fluoromethyl)dioxirane, MFDO, and methyl(difluoromethyl)dioxirane, DFDO, with computational studies, points to a diverse ability of the dioxiranes to either stabilize the homo or the heterolytic pathway.
Organocatalytic Asymmetric Benzylation and Aldol‐Hemiacetalization of α,β‐Unsaturated Trifluoromethyl Ketones: Efficient Enantioselective Construction of 3,4‐Dihydroisocoumarins
Authors: Duan Jindian , Cheng Yuyu , Cheng Jing , Li Rou , Li Pengfei 
Published: October 2016

AbstractA new method has been developed for the organocatalytic enantioselective benzylation and aldol‐hemiacetalization of α,β‐unsaturated trifluoromethyl ketones with toluene derivatives in the presence of a tertiary amine‐thiourea catalyst. This method represents a facile and efficient strategy for the asymmetric synthesis of optically active 3,4‐dihydroisocoumarins bearing a trifluoromethylated tetrasubstituted carbon stereocenter with high enantioselectivity. Notably, this strategy was used to synthesize several chiral trifluoromethylated analogues of typharin with high efficiency.
Tris(imidazolin‐2‐ylidenamino)phosphine: A Crystalline Phosphorus(III) Superbase That Splits Carbon Dioxide
Authors: Mehlmann Paul , Mück‐Lichtenfeld Christian , Tan Tristan T. Y. , Dielmann Fabian 
Published: October 2016

AbstractWe report the synthesis and remarkable properties of the phosphine P(NIiPr)3 (NIiPr=1,3‐diisopropyl‐4,5‐dimethylimidazolin‐2‐ylidenamino), a crystalline solid accessible through a short and scalable route. Evaluation of the electron‐donor properties reveals a Tolman electronic parameter (TEP) value of 2029.7 cm−1 for the new phosphine that is significantly lower than those of all known phosphines or even N‐heterocyclic carbenes. Moreover, P(NIiPr)3 is more basic [pKBH+(MeCN)=38.8] than Verkade's proazaphosphatranes, thus being the strongest reported nonionic phosphorus(III) superbase. The coordination chemistry of the new phosphine towards different metal centers has been explored, and due to its unique electron‐releasing character, the phosphine is capable of capturing and cleaving the CO2 molecule.
ChemInform Abstract: Coupled Electronic and Magnetic Phase Transition in the Infinite‐Layer Phase LaSrNiRuO4.
Authors: Patino Midori Amano , Zeng Dihao , Bower Ryan , McGrady John E. , Hayward Michael A. 
Published: October 2016

AbstractLaSrNiRuO4 is obtained by topochemical reduction of LaSrNiRuO6 with CaH2 at 360 °C.
ChemInform Abstract: Synthesis and Structure Determination of the Novel Aluminophosphate TL‐1: A New Layered Compound with Corner‐Sharing AlX6 Chains.
Authors: Pastero Linda , Arletti Rossella , Camara Fernando , Gigli Lara , Cagnoni Monica 
Published: October 2016

AbstractThe new compound (HMor)4[AlPO4F(H2O)] (HMor: protonated morpholine) is prepared by hydrothermal reaction of an aq.
ChemInform Abstract: Accessing Alkali‐Free NASICON‐Type Compounds Through Mixed Oxoanion Sol—Gel Chemistry: Hydrogen Titanium Phosphate Sulfate, H1‐xTi2(PO4)3‐x (SO4)x (x = 0.5—1).
Authors: Mieritz Daniel , Davidowski Stephen K. , Seo Dong‐Kyun 
Published: October 2016

AbstractThe Ti4+:PO43‐ ratio (1.0—1.5) and the calcination temperature (400—750 °C) are systematically varied in the preparation of the title NASICON‐type compounds.
ChemInform Abstract: New Ternary Tantalum Borides Containing Boron Dumbbells: Experimental and Theoretical Studies of Ta2OsB2 and TaRuB.
Authors: Mbarki Mohammed , Touzani Rachid St. , Rehorn Christian W. G. , Gladisch Fabian C. , Fokwa Boniface P. T. 
Published: October 2016

AbstractTa2OsB2 (I) and TaRuB (II) are prepared by arc‐melting of stoichiometric amounts of the elements.
ChemInform Abstract: Cascade Photoredox/Iodide Catalysis: Access to Difluoro‐γ‐Lactams via Aminodifluoroalkylation of Alkenes.
Authors: Zhang Muliang , Li Weipeng , Duan Yingqian , Xu Pan , Zhang Songlin , Zhu Chengjian 
Published: October 2016

AbstractThe reaction has a broad substrate scope, thus tolerating diversely functionalized styrene derivatives as well as cyclic and acyclic internal alkenes and various N‐arylated bromodifluoroacetamides, but no N‐alkylated derivatives thereof.
ChemInform Abstract: Copper‐Catalyzed Diesterification of 1,3‐Diene for the Synthesis of Allylic Diester Compounds.
Authors: Qian Bo , Xiong Haigen , Zhu Nengbo , Ye Changqing , Jian Wujun , Bao Hongli 
Published: October 2016

AbstractA Cu‐catalyzed addition of aroyloxy radicals to conjugated dienes is studied to provide a synthesis of structural diverse allylic diester derivatives.
ChemInform Abstract: Catalyst‐Free Singlet Oxygen‐Promoted Decarboxylative Amidation of α‐Keto Acids with Free Amines.
Authors: Xu Wen‐Tao , Huang Bei , Dai Jian‐Jun , Xu Jun , Xu Hua‐Jian 
Published: October 2016

AbstractThe mild reaction can be scaled up.
ChemInform Abstract: I2/TBHP Mediated C—N and C—H Bond Cleavage of Tertiary Amines Toward Selective Synthesis of Sulfonamides and β‐Arylsulfonyl Enamines: The Solvent Effect on Reaction.
Authors: Lai Junyi , Chang Liming , Yuan Gaoqing 
Published: October 2016

AbstractPerforming the reaction in H2O delivers sulfonamides whereas DMSO as the solvent provides β‐arylsulfonyl enamines.
ChemInform Abstract: A Cross‐Coupling Synthesis of Functionalized Biaryls Using Knochel‐Type Organozinc Reagents and a Pyridine Enhanced Palladium Catalyst.
Authors: Wang Min , Liu Fang , Zeng Meng‐Tian , Xu Wan , Liu Min , Dong Zhi‐Bing 
Published: October 2016

AbstractThe protocol enables smooth, rapid, and mild Negishi reactions to give the biaryls in excellent yields.
ChemInform Abstract: CuSO4·5H2O‐Catalyzed Aminobenzannulation of ortho‐Alkynylaromatic Ketones with Anilines Approach Towards 1‐Aminonaphthalenes.
Authors: Guo Biao , Hua Ruimao 
Published: October 2016

AbstractAromatic and aliphatic amines are suitable reactants in the title process.
ChemInform Abstract: 2,5‐Oxyarylation of Furans: Synthesis of Spiroacetals via Palladium‐Catalyzed Aerobic Oxidative Coupling of Boronic Acids with α‐Hydroxyalkylfurans.
Authors: Li Jiuyi , Peng Hui , Wang Furong , Wang Xiujun , Jiang Huanfeng , Yin Biaolin 
Published: October 2016

AbstractThe scalable protocol is used for a novel transformation of sustainable furans into 2,5‐oxarylated derivatives.
ChemInform Abstract: Simple Alumina‐Mediated Synthesis of 2‐(2‐Hydroxypropan‐2‐yl)benzofuran‐3(2H)‐ones.
Authors: Fang Lizhen , Han Lili , Liu Saisai , Li Huanhuan 
Published: October 2016

AbstractA novel protocol for the cross‐aldol condensation of acetone (II) and other carbonyl compounds (IV) with benzofuranones is developed using excess basic alumina as the promotor.
ChemInform Abstract: An Acyl‐Claisen/Paal‐Knorr Approach to Fully Substituted Pyrroles.
Authors: Dittrich Nora , Jung Eun‐Kyung , Davidson Samuel J. , Barker David 
Published: October 2016

AbstractA wide variety of syn‐substituted 1,4‐diketones is synthesized using the acyl‐Claisen rearrangement.
ChemInform Abstract: Accessing Benzimidazoles via a Ring Distortion Strategy: An Oxone Mediated Tandem Reaction of 2‐Aminobenzylamines.
Authors: Hati Santanu , Kumar Dutta Pratip , Dutta Sanjay , Munshi Parthapratim , Sen Subhabrata 
Published: October 2016

AbstractThe efficient title reaction of 2‐aminobenzylamines with aryl, hetaryl, and alkyl aldehydes is described.
ChemInform Abstract: Controlling Asymmetric Remote and Cascade 1,3‐Dipolar Cycloaddition Reactions by Organocatalysis.
Authors: Poulsen Pernille H. , Vergura Stefania , Monleon Alicia , Joergensen Danny Kaare Bech , Joergensen Karl Anker 
Published: October 2016

AbstractA regio‐ and stereoselective 1,3‐dipolar cycloaddition of 2,4‐dienals with nitrones is described to give the remote cycloadducts (III) in the presence of a diarylprolinolsilyl ether as catalyst.
ChemInform Abstract: Conformational Control of Chiral Amido‐Thiourea Catalysts Enables Improved Activity and Enantioselectivity.
Authors: Lehnherr Dan , Ford David D. , Bendelsmith Andrew J. , Kennedy C. Rose , Jacobsen Eric N. 
Published: October 2016

AbstractThe theoretical insights gained are experimentally examined performing an enantioselective oxocarbenium alkylation of α‐chloroisochroman with silyl enolates.
ChemInform Abstract: Base Free Regioselective Synthesis of α‐Triazolylazine Derivatives.
Authors: Harisha Mysore Bhyrappa , Nagaraj Muthupandi , Muthusubramanian Shanmugam , Bhuvanesh Nattamai 
Published: October 2016

AbstractA facile regioselective α‐heteroarylation/deoxygenation reaction allows the synthesis of α‐triazolylazines from azine N‐oxides and N‐tosyltriazoles.
ChemInform Abstract: Organocatalytic Stereoselective Addition of Aldehydes to Acylquinolinium Ions.
Authors: Mengozzi Luca , Gualandi Andrea , Cozzi Pier Giorgio 
Published: October 2016

AbstractA direct and simple activation of quinolines, without isolating unstable intermediates, or using isolated N,O‐acetals in the presence of Lewis or Broensted acids, is described.
ChemInform Abstract: Ruthenium‐Catalyzed Dehydrogenative C—H Borylation of Arenes with Pinacolborane.
Authors: Murata Miki , Ueda Yosuke , Hyogo Mayu , Kohari Yoshihito , Namikoshi Takeshi , Watanabe Shinji 
Published: October 2016

AbstractA ruthenium complex is shown to be efficient for the aromatic C—H borylation with pinacolborane.
ChemInform Abstract: Copper‐Catalyzed 8‐Aminoquinoline‐Directed Selenylation of Arene and Heteroarene C—H Bonds.
Authors: Mandal Anup , Sahoo Harekrishna , Baidya Mahiuddin 
Published: October 2016

AbstractThe scalable reaction between various aryl amides and diaryl diselenides provides diversely functionalized ortho‐diselenated products in high yields.
ChemInform Abstract: Palladium‐Catalyzed Direct C—H Arylation of Ferrocenecarboxamides with Aryl Halides.
Authors: Qiao Huijie , Sun Suyan , Yang Fan , Zhu Yu , Zhu Weiguo , Wu Yusheng , Wu Yangjie 
Published: October 2016

AbstractA convenient protocol is developed for the ortho C—H arylation of substrates having a quinolin‐8‐ylamino directing group with aryl bromides.
ChemInform Abstract: Two New Nimbolinin‐Type Limonoids from the Fruits of Melia toosendan.
Authors: Zhang Qiong , Zhang Yong‐Gang , Li Qing‐Shan , Min Zhi‐Da 
Published: October 2016

Abstractisolation, structure determination and cytotoxic activity of the two new limonoids (I), 12‐ethoxynimbolinius E and F, and seven known analogues
ChemInform Abstract: Iriomoteolides‐10a and 12a, Cytotoxic Macrolides from Marine Dinoflagellate Amphidinium Species.
Authors: Akakabe Mai , Kumagai Keiko , Tsuda Masayuki , Konishi Yuko , Tominaga Akira , Kaneno Daisuke , Fukushi Eri , Kawabata Jun , Masuda Atsunori , Tsuda Masashi 
Published: October 2016

AbstractThe cytotoxicity of the newly isolated compounds is examined.
ChemInform Abstract: Eu2+‐Activated Phase‐Pure Oxonitridosilicate Phosphor in a Ba—Si—O—N System via Facile Silicate‐Assisted Routes Designed by First‐Principles Thermodynamic Simulation.
Authors: Yun Young Jun , Kim Jin Kyu , Ju Ji Young , Choi Seul Ki , Park Woon Ik , Jung Ha‐kyun , Kim Yongseon , Choi Sungho 
Published: October 2016

AbstractPhase‐pure, green‐emitting Ba3Si6O12N2:Eu2+ phosphor is obtained by firing (Ba1‐xEux)Si2O5 silicates in alumina crucibles with overcoated graphite powder under a flow of nitrogen containing 5% of H2 (1300 °C, <10 h).