bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotherapie mit adjuvanter Gabe von serotonergen psychoaktiven Substanzen – Möglichkeiten und Hindernisse
Authors: Majić Tomislav , Jungaberle Henrik , Schmidt Timo , Zeuch Andrea , Hermle Leo , Gallinat Jürgen 
Published: August 2017

Zusammenfassung
Hintergrund Der Einsatz von serotonergen Halluzinogenen (Psychedelika) wie Lysergsäure-Diethylamid (LSD) und Psilocybin und Entaktogenen wie 3,4-Methylendioxymethamphetamin (MDMA) im Rahmen von Psychotherapie ist in den letzten Jahren wieder zunehmend ins Licht des wissenschaftlichen Interesses gerückt. Die vorliegende Arbeit fasst die aktuelle Evidenz zur substanzunterstützten Psychotherapie mit serotonergen Psychoaktiva zusammen.
Methode Eine selektive Literaturrecherche erfolgte in PubMed und der Cochrane Library, wobei nach Studien gesucht wurde, in denen der Einsatz von serotonergen Psychoaktiva in der Psychotherapie seit 2000 untersucht wurde.
Ergebnisse Es fanden sich Studien für die folgenden Behandlungsindikationen: Alkoholabhängigkeit (LSD und Psilocybin), Nikotinabhängigkeit (Psilocybin), Behandlung von Angst und Depression bei lebensbedrohlicher körperlicher Erkrankung (LSD und Psilocybin), Zwangsstörungen (Psilocybin), therapieresistente Major Depression (Psilocybin) und posttraumatische Belastungsstörung (MDMA).
Diskussion Abhängigkeitserkrankungen, posttraumatische Belastungsstörung sowie Angst und Depression bei lebensbedrohlicher körperlicher Erkrankung stellen derzeit die am besten evaluierten Indikationen für die substanzunterstützte Psychotherapie mit serotonergen Psychoaktiva dar. Bisher zeigten sich Hinweise für eine Wirksamkeit bei relativ guter Verträglichkeit. Weitere Studien sind erforderlich, um einzuschätzen, ob diese Substanzen in Zukunft in der Behandlung bestimmter therapieresistenter psychischer Erkrankungen eine Option darstellen können.
Singultus – Diagnostik und Therapie
Authors: Marcus Ohlrich , Royl Georg 
Published: August 2017

ZusammenfassungDer Schluckauf (Singultus) ist ein reflektorischer Bewegungsablauf mit diffus im Thorax verteilten Afferenzen und Efferenzen und kontrovers
diskutierter funktioneller Relevanz. In seiner physiologischen Form handelt es sich um eine meist spontan sistierende Bagatellbeschwerde,
die nur selten zum Arztkontakt führt. Ein anhaltender quälender Singultus kann jedoch zu einer erheblichen Beeinträchtigung der
Lebensqualtiät führen. Ein solcher chronischer Singultus wird im Allgemeinen durch eine Dauer von mehr als 48 h definiert. Häufigste
zugrundeliegende Erkrankung ist der gastroösophageale Reflux. Die weiteren Ursachen für einen chronischen Singultus sind vielfältig und
betreffen multiple Organsysteme mit zum Teil schwerwiegenden Grunderkrankungen. In einigen Fällen können sich auch neurologische
Erkrankungen mit einem Schluckauf präsentieren, zum Teil ist er sogar das einzige Symptom im Rahmen der Erstmanifestation. In der zerebralen
Bildgebung findet sich dann häufig eine Läsion der Medulla oblongata. Eine Neuromyelitis optica und ein ischämischer Hirninfarkt mit
Wallenbergsyndrom sind 2 häufigere zugrundeliegende neurologische Erkrankungen, aber auch andere entzündliche und vaskuläre Erkrankungen und
Tumorerkrankungen des zentralen Nervensystems sind beschrieben. Für ein optimales evidenzbasiertes Management der Diagnostik und Therapie
des chronischen Singultus gibt es keine hinreichenden Daten. Die Suche nach der Grunderkrankung erfordert oft ein interdisziplinäres
Vorgehen von Internisten, Neurologen und HNO-Ärzten. Bereits vor Abschluss der Diagnostik oder bei nicht behebbarer Ursache kann eine
symptomatische Therapie erforderlich sein. Der anhaltende Schluckauf stellt auch ein häufiges Problem in der onkologischen
Palliativversorgung dar. Die medikamentöse Therapie des Singultus ist oft diffizil. Protonenpumpenhemmer oder Prokinetika bei
gastroösophagealer Ursache bzw. Baclofen mit oder ohne Gabapentin bei anderer Ursache gehören dabei zu den Mitteln der ersten Wahl. Weitere
Alternativen sind andere Antikonvulsiva, Neuroleptika, Antidepressiva und Kalziumantagonisten. Für den therapierefraktären Verlauf stehen
grundsätzlich auch invasive Verfahren wie z. B. die selektive Phrenicusblockade zur Verfügung. Insgesamt wären mehr Studien zum Singultus
wünschenswert, um der therapeutischen und diagnostischen Herausforderung gerecht zu werden, die dieses Symptom für Neurologen darstellen
kann.
Laryngopharyngeale Refluxerkrankung (LPRD) bei
Kindern
Authors: Reichel Oliver , Saravakos Panagiotis , Lorenz Kai J. 
Published: August 2017

ZusammenfassungZwischen 5 und 20 % aller Kinder leiden an einer gastroösophagealen
Refluxerkrankung (GERD), die zu Erosionen, Ulzera und Metaplasien der
Ösophagusschleimhaut führen kann. Überwindet der Mageninhalt in pathologischer
Häufigkeit und Intensität auch den kindlichen oberen Ösophagussphinkter, liegt
eine laryngopharyngeale Refluxerkrankung (LPRD) vor. Die mit einer kindlichen
LPRD assoziierten Symptome und Folgeerkrankungen sind äußerst vielfältig.
Teilhabebezogene Verlaufstypen in der Schlaganfallrehabilitation – Subgruppenanalyse der Daten einer multizentrischen
Beobachtungsstudie zur ambulanten Rehabilitation nach Schlaganfall
Authors: Marheineke Judit , Deck Ruth , Reuther Paul , Pöppl Dominik 
Published: August 2017

Zusammenfassung
Hintergrund Es wurde eine Verlaufstypenanalyse hinsichtlich der Teilhabemaße von Schlaganfallpatienten in der ambulanten
Neurorehabilitation durchgeführt. Diese weist eine Reihe von Vorteilen gegenüber der Methode des Mittelwertvergleichs auf und erlaubt erste
Untersuchungen zu den Rehaverlauf beeinflussenden Kontextvariablen.
Methodik In einer multizentrischen Beobachtungsstudie wurden Rehabilitanden nach einem Schlaganfall in 17 ambulanten neurologischen
Rehabilitationszentren in Deutschland innerhalb eines festgelegten Zeitraums befragt. Die Erhebung der Selbsteinschätzung der
Teilhabesituation der Rehabilitanden mittels Fragebögen fand zu Beginn und Ende der Rehabilitationsmaßnahme sowie 4 und 12 Monate danach
statt, zusätzlich erfolgte zu Beginn und Ende der Maßnahme eine Fremdeinschätzung durch die behandelnden Ärzte.
Ergebnisse und Schlussfolgerungen Es konnten die Daten von 364 Schlaganfallpatienten gewonnen werden. Die Verlaufstypenanalyse zeigte,
dass die Teilhabe bei 36 (9,9 %) der 364 Teilnehmer im Verlauf der Rehamaßnahme als verschlechtert angegeben wurde. 173 (47,5 %) Probanden
gaben keine Veränderung der Teilhabe an, und bei 155 (42,6 %) der Teilnehmer zeigte sich zum Ende der Rehabilitation eine Verbesserung der
Teilhabe. Bei 99 der 173 Teilnehmer, die keine Veränderung zeigten, lagen allerdings schon zu Beginn Teilhabemaße im kaum beeinträchtigten
Bereich vor, was in Bezug auf die Rehabilitationsindikation diskutiert wird. Hinsichtlich der untersuchten soziodemographischen Variablen
fanden sich lediglich in Bezug auf Geschlecht und Nettoeinkommen signifikante Einflüsse auf den Rehaverlauf, so dass weitere Forschung
hinsichtlich der starken Varianz der Rehaverläufe notwendig erscheint.
Combined Effects of Fatigue and Surface Instability on Jump Biomechanics in Elite Athletes
Authors: Prieske Olaf , Demps Marie , Lesinski Melanie , Granacher Urs 
Published: August 2017

AbstractThe present study aimed to examine the effects of fatigue and surface instability on kinetic and kinematic jump performance measures. Ten female and 10 male elite volleyball players (18±2 years) performed repetitive vertical double-leg box jumps until failure. Pre and post fatigue, jump height/performance index, ground reaction force and knee flexion/valgus angles were assessed during drop and countermovement jumps on stable and unstable surfaces. Fatigue, surface condition, and sex resulted in significantly lower drop jump performance and ground reaction force (p≤0.031, 1.1≤d≤3.5). Additionally, drop jump knee flexion angles were significantly lower following fatigue (p=0.006, d=1.5). A significant fatigue×surface×sex interaction (p=0.020, d=1.2) revealed fatigue-related decrements in drop jump peak knee flexion angles under unstable conditions and in men only. Knee valgus angles were higher on unstable compared to stable surfaces during drop jumps and in females compared to males during drop and countermovement jumps (p≤0.054, 1.0≤d≤1.1). Significant surface×sex interactions during countermovement jumps (p=0.002, d=1.9) indicated that knee valgus angles at onset of ground contact were significantly lower on unstable compared to stable surfaces in males but higher in females. Our findings revealed that fatigue and surface instability resulted in sex-specific knee motion strategies during jumping in elite volleyball players.
A Novel Two-Velocity Method for Elaborate Isokinetic Testing of Knee Extensors
Authors: Grbic Vladimir , Djuric Sasa , Knezevic Olivera , Mirkov Dragan , Nedeljkovic Aleksandar , Jaric Slobodan 
Published: August 2017

AbstractSingle outcomes of standard isokinetic dynamometry tests do not discern between various muscle mechanical capacities. In this study, we aimed to (1) evaluate the shape and strength of the force-velocity relationship of knee extensors, as observed in isokinetic tests conducted at a wide range of angular velocities, and (2) explore the concurrent validity of a simple 2-velocity method. Thirteen physically active females were tested for both the peak and averaged knee extensor concentric force exerted at the angular velocities of 30°–240°/s recorded in the 90°–170° range of knee extension. The results revealed strong (0.960<R<0.998) linear force-velocity relationships that depict the maximum muscle force (i.e. the force-intercept), velocity (velocity-intercept), and power (their product). Moreover, the line drawn through only the 60° and 180°/s data (the ‘2-velocity method’) revealed a high level of agreement with the force-velocity relationship obtained (0.76<R<0.97; all power<0.001); while the force-intercept highly correlated (0.68<R<0.84; all power≤0.01) with the directly measured isometric force. The 2-velocity method could therefore be developed into a standard method for isokinetic testing of mechanical capacities of knee extensors and, if supported by further research, other muscles. This brief and fatigue-free testing procedure could discern between muscle force, velocity, and power-producing capacities.
Tiefe Hirnstimulation bei Bewegungsstörungen: Evidenz und Therapiestandards
Authors: Parpaley Yaroslav , Skodda Sabine 
Published: August 2017

AbstractThe deep brain stimulation (DBS) in movement disorders is well established and in many aspects evidence-based procedure. The treatment indications are very heterogeneous and very specific in their course and therapy. The deep brain stimulation plays very important, but usually not the central role in this conditions. The success in the application of DBS is essentially associated with the correct, appropriate and timely indication of the therapy in the course of these diseases. Thanks to the good standardization of the DBS procedure and sufficient published data, the recommendations for indication, diagnosis and operative procedures can be generated. The following article attempts to summarize the most important decision-making criteria and current therapy standards in this fairly comprehensive subject and to present them in close proximity to practice.
Upper Extremity Strength Imbalance after Mastectomy and the Effect of Resistance Training
Authors: Benton Melissa , Schlairet Maura 
Published: August 2017

AbstractThe purpose of this non-randomized pre/post comparison trial was to explore the effect of resistance training (RT) on upper extremity strength imbalance in breast cancer survivors. Seventeen right-side dominant female breast cancer survivors (age: 58.2±2.7 years; BMI: 27.8±1.1 kg/m2) with right-sided (RSM) or left-sided (LSM) mastectomy completed strength testing (30-second arm curl) before and after an 8-week RT program. At baseline, LSM (n=8) had equal strength bilaterally (right=16.8±1.1 repetitions; left=16.4±1.4 repetitions), whereas RSM (n=9) had impaired strength on the right (16.7±1.3 repetitions) compared to the left (18.6±1.1 repetitions) side (p<0.01). After RT, RSM increased strength by 25% on the right (initially weaker) side and 19% on the left (initially stronger) side, which resolved the imbalance. By comparison LSM increased 19% on both sides that were initially equal in strength. Based on our findings, breast cancer survivors with dominant-side mastectomy are at risk for upper extremity strength imbalance that can be resolved with a relatively short-term RT program.
Transnational Europe: TV-drama, co-production networks and mediated cultural encounters
Authors: Bondebjerg Ib 
Published: August 2017

AbstractThis article deals with the social and cultural dimensions of globalization and uses both qualitative and quantitative methods to analyse the effects of stronger European integration on media production and reception. It combines theories and methods from sociology, anthropology and media studies and looks at the impact of TV drama genres on the forming of social imaginaries. The article examines structural changes in production and distribution in the European TV-drama landscape since 2000. On the basis of empirical evidence it is argued that a creative, transnational European network of co-productions has increased the distribution of original and often local stories in Europe. The article analyses examples of some successful European drama series, their audiences and reception. The analysis is discussed in the context of national and transnational media policy and the impact of globalisation. Concepts like “imagined community”, “social imaginary”, “banal nationalism”, and “mediated cultural encounters” are connected to the theory of cultural globalisation. Also touched upon are studies of a European civic and cultural identity next to the national, and the role of media and cultural policy in this development. The article concludes that encounters of the kind we find in different forms of TV drama will make Europe more diverse and richer for a much broader audience. The interaction between the particular and universal in “narratives” on our past and contemporary social and cultural order contribute to a better feeling for and understanding of the “us” and “them” in European culture.
Tobacco industry globalization and global health governance: towards an interdisciplinary research agenda
Authors: Lee Kelley , Eckhardt Jappe , Holden Chris 
Published: August 2017

AbstractShifting patterns of tobacco production and consumption, and the resultant disease burden worldwide since the late twentieth century, prompted efforts to strengthen global health governance through adoption of the Framework Convention on Tobacco Control. While the treaty is rightfully considered an important achievement, to address a neglected public health issue through collective action, evidence suggests that tobacco industry globalization continues apace. In this article, we provide a systematic review of the public health literature and reveal definitional and measurement imprecision, ahistorical timeframes, transnational tobacco companies and the state as the primary units and levels of analysis, and a strong emphasis on agency as opposed to structural power. Drawing on the study of globalization in international political economy and business studies, we identify opportunities to expand analysis along each of these dimensions. We conclude that this expanded and interdisciplinary research agenda provides the potential for fuller understanding of the dual and dynamic relationship between the tobacco industry and globalization. Deeper analysis of how the industry has adapted to globalization over time, as well as how the industry has influenced the nature and trajectory of globalization, is essential for building effective global governance responses. This article is published as part of a thematic collection dedicated to global governance.
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling
Authors: Hughes Mark M. , Lavrencic Peter , Coll Rebecca C. , Ve Thomas , Ryan Dylan G. , Williams Niamh C. , Menon Deepthi , Mansell Ashley , Board Philip G. , Mobli Mehdi , Kobe Bostjan , O’Neill Luke A. J. 
Published: August 2017

Significance
Toll-like receptor (TLR) signaling pathways are targeted to limit inflammation in immune cells. TLRs use adaptor proteins to drive inflammatory signaling platforms for effective microbial clearance. Here we show that MyD88 adaptor-like (MAL), an adaptor protein in TLR signaling, undergoes glutathionylation in response to LPS, driving macrophage responses to proinflammatory stimuli. We also determined the solution structure of MAL in the reduced form without disulfides, revealing a typical BB loop observed in adaptor proteins, in contrast to previously reported crystal structures. This alternate solution structure reveals the inherent flexibility of MAL, supporting the hypothesis that glutathionylation may reposition the MAL BB loop for MyD88 interaction to drive inflammation. This discovery could lead to novel approaches to target MAL glutathionylation in dysregulated TLR signaling, limiting inflammation.
Structural basis of kindlin-mediated integrin recognition and activation
Authors: Li Huadong , Deng Yi , Sun Kang , Yang Haibin , Liu Jie , Wang Meiling , Zhang Zhang , Lin Jirong , Wu Chuanyue , Wei Zhiyi , Yu Cong 
Published: August 2017

Significance
Kindlin proteins play crucial roles in the integrin-signaling pathway by directly interacting with and activating integrins, which mediate the cell–extracellular matrix adhesion and signaling. Mutations of kindlins lead to diseases, such as Kindler syndrome, associated with skin blistering and atrophy; leukocyte adhesion deficiency; and cancers. However, the molecular basis underlying kindlin-mediated integrin activation remains to be determined. Here, we report the structural basis of the specific interaction between kindlins and integrins. Furthermore, we demonstrate that kindlins synergize integrin activation by forming a dimer, providing a model for understanding integrin signaling. Finally, we interpret disease-causing mutations found in kindlins at the atomic level, which can be useful for understanding and treating these diseases.
Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies
Authors: Best Katharine , Guedj Jeremie , Madelain Vincent , de Lamballerie Xavier , Lim So-Yon , Osuna Christa E. , Whitney James B. , Perelson Alan S. 
Published: August 2017

Significance
In light of the recent outbreak of Zika virus (ZIKV), an understanding of the within-host viral dynamics is essential to assess persistence in vivo, transmission risk, and antiviral therapeutics. Using mathematical modeling we find that, in nonhuman primates, the viral dynamics of ZIKV are characterized by a short lifetime of infected cells (<10 h) during which enough viral particles are produced to infect ∼11 other cells. Higher disease burden is associated with changes in natural killer cell subset concentrations and with elevated expression of the cytokine MCP-1, although the mechanisms behind these associations remain unclear. In order for an antiviral treatment to effectively reduce the time to plasma viral clearance therapy should be initiated at the time of infection or given prophylactically.
Unique structural features of the AIPL1–FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness
Authors: Yadav Ravi P. , Gakhar Lokesh , Yu Liping , Artemyev Nikolai O. 
Published: August 2017

Significance
Mutations in the gene encoding aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) disrupt the ability of this protein to function as a chaperone of prenylated photoreceptor phosphodiesterase 6, and cause a severe form of childhood blindness. Our discovery of two features—the unique structure of the AIPL1–FKBP domain essential for its binding of prenyl lipids, and the unusual conformational dynamics altered by pathogenic mutations—advances our understanding of both the protein structure and dynamics required for prenyl binding. Moreover, our studies provide a molecular mechanism underlying the blindness disease.
Toward broadband mechanical spectroscopy
Authors: Hecksher Tina , Torchinsky Darius H. , Klieber Christoph , Johnson Jeremy A. , Dyre Jeppe C. , Nelson Keith A. 
Published: August 2017

Significance
Viscous liquids of all kinds, from honey to glycerol to common polymers, display remarkably similar dynamical properties upon cooling from high temperatures at which local structural relaxation and flow occur quickly, to moderate temperatures at which key components of the dynamics slow down dramatically, to cold temperatures at which a glassy solid is formed. The similarities suggest a common theoretical framework, but comprehensive measurements of liquids’ mechanical properties covering the extraordinary range of time scales spanned have been elusive. Using seven experimental methods covering 13 decades with few gaps, we demonstrate that broadband mechanical spectra are now within reach. Data obtained for the molecular glass former studied, a commercial silicone oil, follow key scaling laws predicted long ago.
Menscheln, kibbelen, sparkle
Authors: Audring Jenny , Booij Geert , Jackendoff Ray 
Published: August 2017

Abstract
German, Dutch and English have surprisingly large sets of verbal diminutives: verbs ending in
-el/-le and carrying an attenuative and/or iterative meaning. These verbs exhibit particular
properties that make them interesting for morphological theory. Focussing on Dutch data, this paper sketches the challenges that
arise with respect to structure, productivity and meaning, and proposes a constructionist account that allows for a better
understanding of the issues. The central notion is the schema, a generalization over the structure of complex
words. In contrast to rules, whose main function is to generate new words, schemas motivate existing words by
marking their structure as non-arbitrary. We discuss the modelling options this gives us and apply them to the verbal
diminutives.
The rise of clause-final negation in Flores-Lembata, Eastern
Indonesia
Authors: Fricke Hanna 
Published: August 2017

Abstract
The Austronesian languages of Flores-Lembata in eastern Indonesia show all three
stages of a Jespersen Cycle: some have a negator in pre-predicate position,
others in clause-final position, and yet others have embracing double negation.
In this article the various negation patterns in the Flores-Lembata languages
are described using a sample of nine closely related languages of the region. It
examines not only the negative constructions but also the etymology of the
negators used, showing historical connections between some of the languages, as
well as independent developments in others. On the basis of cross-linguistic
evidence, and taking into account the non-Austronesian (Papuan) structures found
in these Flores-Lembata languages, it is argued that the clause-final negation
in several of these languages was caused by contact with speakers of Papuan
languages during an earlier stage.