bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voluntary Turnover Rate Fluctuations, Human Resource Practices, and Innovation: A Within‐Organization Investigation
Authors: Li Yixuan , Huang Zhefan , Dineen Brian , Wang Mo , van Jaarsveld Danielle 
Published: September 2024

ABSTRACTOrganizations constantly navigate voluntary employee departures to facilitate organizational effectiveness. To date, most studies on the implications of voluntary turnover rate have been conducted at the between‐organization level, comparing organizations with varying levels of voluntary turnover rates. Building upon complex adaptive system (CAS) theory, we develop within‐organization theorizing regarding the implications of voluntary turnover rate fluctuations for organizational innovation. We propose a U‐shape threshold model, where the relationship between voluntary turnover rate fluctuations and innovation takes a negative form when voluntary turnover rate fluctuations are within the normal range for an organization, and a positive form when voluntary turnover rate fluctuations surpass a critical threshold reflecting far‐from‐equilibrium conditions. Furthermore, we investigate how organizations may utilize human resource (HR) practices to shift the critical threshold. Specifically, we argue that increased reliance on interaction‐facilitating HR practices (employee participation and group‐based pay) lowers the threshold, while increased reliance on interaction‐inhibiting HR practices (individual‐based pay) raises the threshold. With firm‐fixed effects modeling, we found general support for our hypotheses using a large‐scale, multi‐level, longitudinal dataset from Statistics Canada (7110 workplace‐year observations from 1980 workplaces). We provide a novel theoretical lens to understand the nature and management of collective turnover.
Periodontal regeneration using platelet‐rich fibrin. Furcation defects: A systematic review with meta‐analysis
Authors: Miron Richard J. , Moraschini Vittorio , Estrin Nathan E. , Shibli Jamil Awad , Cosgarea Raluca , Jepsen Karin , Jervøe‐Storm Pia‐Merete , Sculean Anton , Jepsen Søren 
Published: September 2024

AbstractThe objective of the study was to compare the treatment outcomes of periodontal furcation defects by using platelet‐rich fibrin (PRF) with other commonly utilized modalities. The eligibility criteria comprised randomized controlled trials (RCTs) comparing the clinical outcomes of PRF with those of other modalities for the treatment of furcation defects. Studies were classified into 11 categories in 3 different groups as follows: Group I (addition of PRF): (1) open flap debridement (OFD) alone versus OFD/PRF, (2) OFD/bone graft (OFD/BG) versus OFD/BG/PRF; Group II (comparative studies to PRF): (3) OFD/BG versus OFD/PRF, (4) OFD/collagen membrane versus OFD/PRF, (5) OFD/PRP versus OFD/PRF, (6) OFD/rhBMP2 versus OFD/PRF; and Group III (addition of biomaterial/biomolecule to PRF): OFD/PRF versus … (7) OFD/PRF/BG, (8) OFD/PRF/amniotic membrane (AM), (9) OFD/PRF/metformin, (10) OFD/PRF/bisphosphonates, (11) OFD/PRF/statins. Weighted means and forest plots were calculated for the reduction of probing pocket depth (PPD), gain of vertical and horizontal clinical attachment levels (VCAL and HCAL), gain in vertical and horizontal bone levels (VBL, HBL), and radiographic bone fill (RBF). From 45 articles identified, 21 RCTs reporting on class II furcations were included. The use of OFD/PRF and OFD/BG/PRF statistically significantly reduced PPD and improved VCAL and HCAL when compared to OFD or OFD/BG, respectively. The comparison between OFD/PRF alone versus OFD/BG, OFD/CM, OFD/PRP, or OFD/rhBMP2 led to similar outcomes for all investigated parameters, including a reduction in PPD, VCAL/HCAL gain, and RBF. The additional incorporation of a BG to OFD/PRF only mildly improved outcomes, whereas the addition of AM improved clinical outcomes. The addition of small biomolecules such as metformin, bisphosphonates, or statins all led to significant improvements in PPD, VCAL, and HCAL when compared to OFD/PRF alone. Noteworthy, a very high heterogeneity was found in the investigated studies. The use of PRF significantly improved clinical outcomes in class II furcation defects when compared to OFD alone, with similar levels being observed between OFD/PRF and/or OFD/BG, OFD/CM, OFD/PRP, or OFD/rhBMP2. Future research geared toward better understanding potential ways to enhance the regenerative properties of PRF with various small biomolecules may prove valuable for future clinical applications. Future histological research investigating PRF in human furcation defects is largely needed. The use of PRF in conjunction with OFD statistically significantly improved PPD, VCAL, and HCAL values, yielding comparable outcomes to commonly used biomaterials. The combination of PRF to bone grafts or the addition of small biomolecules may offer additional clinical benefits, thus warranting future investigation.
Returning home from exile? Arnold Cornelisz's ministerial networks and the religious landscape of the liberated Netherlands☆
Authors: Muylaert Silke 
Published: September 2024

AbstractScholars of the Dutch Reformation have attributed the rapid development of Reformed churches in the liberated areas of the Northern Netherlands after 1572 to the immigration of radical migrants from Flanders or returning exiles who learned the trade in the refugee churches outside the Low Countries. However, the impact of the networks, rather than the ideology, of a third transformative stream of migrants often gets overlooked. This article argues that a wider network of mobile ministers centred around the University of Heidelberg had a profound impact on the religious landscape of the Low Countries. It demonstrates this using a network analysis of the correspondence of one of the leading Reformed ministers in the liberated Netherlands after 1572, Arnold Cornelisz, combined with a prosopographical examination of the network. The idea that exile brought innovation through the formation of networks itself is not new. Yet, the article suggest that scholars should also take into account the interaction of exile with other forms of migration. Although Reformed ministers did not always recognize themselves as refugees or exiles, they were part of a large, transferable network that formed an innovative force after their return to the Low Countries.
Establishment of a Mouse Model for Porokeratosis Due to Mevalonate Diphosphate Decarboxylase Deficiency
Authors: Peng Kexin , Wong Wenghong , Zhang Qiaoan , La Yumeng , Tian Zhen , Sun Ruilin , Ho Loksi , Yang Kaihang , Pan Jiewen , Luan Jing , Niu Zhenmin , Zhang Zhenghua 
Published: September 2024

ABSTRACTIntroductionPorokeratosis (PK) is an autoinflammatory keratinization disease (AIKD) characterized by circular or annular skin lesions with a hyperkeratotic rim, pathologically shown as the cornoid lamella. Four genes that cause PK are associated with the mevalonate (MV) pathway. In Chinese PK patients, mevalonate diphosphate decarboxylase (MVD) is the most common causative gene. The lack of an animal model has greatly limited research on PK pathogenesis.Materials and MethodsIn this research, we constructed K14‐CreERT2‐Mvdfl/fl mice using the Cre‐LoxP system to create a mouse model for in‐depth studies of PK. The Epidermal Mvd gene was knocked out by intraperitoneal injection of Tamoxifen (TAM). Pathology, immunohistochemistry, RNA‐seq, and Western Blot analysis were performed.ResultsSkin lesions appeared following Mvd deficiency, and pathological examination revealed the characteristic cornoid lamella, as well as cutaneous inflammation. Furthermore, we observed elevated levels of IL‐17A and IL‐1β, and a decreased Loricrin level in epidermal Mvd‐deficient mice. Compared with the wild‐type (WT) group, Mvd deficiency activated the expression of lipid metabolism‐related proteins.ConclusionWe developed the first mouse model for PK research, enabling further studies on disease development and treatment approaches.
How can soil data and information become actionable knowledge to advance sustainable land management?
Authors: Lobry de Bruyn Lisa , Prager Katrin 
Published: September 2024

AbstractPromoting sustainable land management is key to addressing land degradation but its progress is impeded by the availability and accessibility of the ‘right’ soil data and information. We focus on government‐funded data collection or publicly collected soil data as it is central to effective soil governance. Taking a governance perspective, we discuss what soil information is created and used for, who are the actors involved and how soil information is contributing (or not) to the creation of actionable knowledge. We investigated two countries in depth through a desk‐based review and consultation with 40 key informants, collating which soil data and information is collected, analysed, stored, retrieved and used in the UK and Australia. We present a comprehensive overview of public soil databases, including location, year established, stated purpose, current governing institution, accessibility, digital product/s available, cycle of assessment, scale of sampling, soil data presented and depth of soil assessment. The analysis highlights that current shortcomings in soil governance are a result of not adequately valuing legacy soil data and information, and with the loss of human capital, diminished accessibility to soil information leads to disrupted information flows. A critical assessment suggests that available soil information plays a limited role in knowing the soil types of a locality, the condition of soil under various land uses and associated management, which limits its potential for informing sustainable land management. In both countries, there is a mismatch in scale and intention of use for the soil information between the provider and the user: information is currently held at the scale for regional‐ or nation‐level reporting on targets to meet national and international obligations rather than improving soil health or SLM at the farm scale. In addition, available soil data repositories only partially meet accessibility criteria (discoverability, language applicable to audience, open source and interpretative layer for land management implications). We outline steps to improve soil information and knowledge exchange embedded in effective governance arrangements to ensure that soil data and information can become actionable knowledge for SLM. Applying principles and strategies for facilitating knowledge exchange is of particular relevance to this process.
Uracil phosphoribosyltransferase is required to establish a functional cytochrome b6f complex
Authors: Scherer Vanessa , Bellin Leo , Schwenkert Serena , Lehmann Martin , Rinne Jannis , Witte Claus‐Peter , Jahnke Kathrin , Richter Andreas , Pruss Tobias , Lau Anne , Waller Lisa , Stein Sebastian , Leister Dario , Möhlmann Torsten 
Published: September 2024

SUMMARYArabidopsis uracil phosphoribosyltransferase (UPP) is an essential enzyme and plants lacking this enzyme are strongly compromised in chloroplast function. Our analysis of UPP amiRNA mutants has confirmed that this vital function is crucial to establish a fully functional photosynthesis as the RIESKE iron sulfur protein (PetC) is almost absent, leading to a block in photosynthetic electron transport. Interestingly, this function appears to be unrelated to nucleotide homeostasis since nucleotide levels were not altered in the studied mutants. Transcriptomics and proteomic analysis showed that protein homeostasis but not gene expression is most likely responsible for this observation and high light provoked an upregulation of protease levels, including thylakoid filamentation temperature‐sensitive 1, 5 (FtsH), caseinolytic protease proteolytic subunit 1 (ClpP1), and processing peptidases, as well as components of the chloroplast protein import machinery in UPP amiRNA lines. Strongly reduced PetC amounts were not only detected by immunoblot from mature plants but in addition in a de‐etiolation experiment with young seedlings and are causing reduced high light‐induced non‐photochemical quenching Φ(NPQ) but increased unregulated energy dissipation Φ(NO). This impaired photosynthesis results in an inability to induce flavonoid biosynthesis. In addition, the levels of the osmoprotectants raffinose, proline, and fumarate were found to be reduced. In sum, our work suggests that UPP assists in stabilization PetC during import, processing or targeting to the thylakoid membrane, or protects it against proteolytic degradation.
SlBTB19 interacts with SlWRKY2 to suppress cold tolerance in tomato via the CBF pathway
Authors: Xu Jin , Liu Sidi , Hong Jiachen , Lin Rui , Xia Xiaojian , Yu Jingquan , Zhou Yanhong 
Published: September 2024

SUMMARYCold stress restricts the metabolic and physiological activities of plants, thereby affecting their growth and development. Although broad‐complex, tramtrack, and bric‐à‐brac (BTB) proteins are essential for diverse biological processes and stress responses, the mechanisms underlying BTB‐mediated cold responses remain not fully understood. Here, we characterize the function of the cold‐induced SlBTB19 protein in tomato (Solanum lycopersicum). Overexpression of SlBTB19 resulted in increased plant sensitivity to cold stress, whereas SlBTB19 knockout mutants exhibited a cold‐tolerance phenotype. Further analyses, including protein–protein interaction studies and cell‐free degradation assays, revealed that SlBTB19 interacts with and destabilizes the transcription factor SlWRKY2. Using virus‐induced gene silencing (VIGS) to silence SlWRKY2 in both wild‐type and slbtb19 mutants, we provided genetic evidence that SlWRKY2 acts downstream of SlBTB19 in regulating cold tolerance. Importantly, we demonstrated that SlWRKY2 positively regulates cold tolerance in a CRT/DRE binding factor (CBF)‐dependent manner. Under cold stress, SlWRKY2 binds to the W‐box in the CBF1 and CBF3 promoters, directly activating their expression. In summary, our findings identify a SlBTB19‐SlWRKY2 module that negatively regulates the CBF‐dependent cold tolerance pathway in tomato.
Post‐Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient‐Limited Cancer Cells
Authors: Güleç Taşkıran Aliye Ezgi , Hüsnügil Hepşen H. , Soltani Zahra E. , Oral Göksu , Menemenli Nazlı S. , Hampel Chuanpit , Huebner Kerstin , Erlenbach‐Wuensch Katharina , Sheraj Ilir , Schneider‐Stock Regine , Akyol Aytekin , Liv Nalan , Banerjee Sreeparna 
Published: September 2024

ABSTRACTLimited nutrient availability in the tumor microenvironment can cause the rewiring of signaling and metabolic networks to confer cancer cells with survival advantages. We show here that the limitation of glucose, glutamine and serum from the culture medium resulted in the survival of a population of cancer cells with high viability and capacity to form tumors in vivo. These cells also displayed a remarkable increase in the abundance and size of lysosomes. Moreover, lysosomes were located mainly in the perinuclear region in nutrient‐limited cells; this translocation was mediated by a rapid post‐transcriptional increase in the key endolysosomal trafficking protein Rab7a. The acidic lysosomes in nutrient‐limited cells could trap weakly basic drugs such as doxorubicin, mediating resistance of the cells to the drug, which could be partially reversed with the lysosomal inhibitor bafilomycin A1. An in vivo chorioallantoic membrane (CAM) assay indicated a remarkable decrease in microtumor volume when nutrient‐limited cells were treated with 5‐Fluorouracil (5‐FU) and bafilomycin A1 compared to cells treated with either agent alone. Overall, our data indicate the activation of complementary pathways with nutrient limitation that can enable cancer cells to survive, proliferate and acquire drug resistance.
Ultrasonographic diagnosis of a cecal mucocele in a cat
Authors: Louvet Arnaud , Duconseille Anne‐Carole , Gatineau Matthieu , Albert Audrey 
Published: September 2024

AbstractA 3‐year‐old neutered male domestic medium‐hair cat presented for sudden onset of vomiting and anorexia. Ultrasonographically, severe distension of the cecum by hyperechoic material associated with variable posterior attenuation was identified. The cecum was surgically excised. A retention cyst cecal mucocele complicated by mucosal ulceration and inflammation was diagnosed. A literature review of this well‐described lesion in humans, once described in dogs but as yet undescribed in cats, is briefly presented.
Novel multi‐spectral short‐wave infrared imaging for assessment of human burn wound depth
Authors: Nunez Johanna , Mironov Sergey , Wan Bingchun , Hazime Alaa , Clark Audra , Akarichi Chiaka , Abdelfattah Kareem , Korlakunta Sneha , Mandell Samuel , Arnoldo Brett , Chan Rodney , Goverman Jeremy , Huebinger Ryan , Park Caroline , Evers Bret , Carlson Deborah , Berenfeld Omer , Levi Benjamin 
Published: September 2024

AbstractBurn depth determination is critical for patient care but is currently lacking accuracy. Recent animal studies showed that Short Wave Infrared (SWIR) imaging can distinguish between superficial and deep burns. This is a first human study correlating reflectance of multiple SWIR bands using a SWIR assessment tool (SWAT) with burn depth classifications by surgeons and histology. Burns and adjacent normal skin in 11 patients with thermal injuries were imaged with visual and narrow bands centred at 1200, 1650, 1940 and 2250 nm and biopsies were taken from select areas. Reflectance intensities for each band in 273 regions of interest (ROI) were divided by the normal skin reflectance and combined into three Reflectance Indices (RIs). In addition, burns in ROIs and biopsies were classified by five surgeons and three pathologists, respectively, as superficial partial, deep partial, or full thickness. Results show that for burn depth increase classified by the surgeons, reflectance increased at 1200 and 2250, decreased at 1940, and didn't change at 1650 nm. In contrast, all three RIs increase with burn depth and predict the deep and full depths ROIs representing operable regions (Area Under Curve >0.6507, p < 0.0001). Pathologists' classification matched surgeons' classification of burn category only in eight of 21 biopsies (38.1%), but reflectance at all bands and one RI for all deep partial and full thickness biopsies were larger than in non‐biopsy normal and superficial partial thickness ROIs (p < 0.0118). In conclusion, multi‐spectral imaging with a new SWAT is a promising approach for evaluation of burn wound depth.
Tiling with monochromatic bipartite graphs of bounded maximum degree
Authors: Girão António , Janzer Oliver 
Published: September 2024

AbstractWe prove that for any , there exists a constant such that the following is true. Let be an infinite sequence of bipartite graphs such that and hold for all . Then, in any ‐edge‐coloured complete graph , there is a collection of at most monochromatic subgraphs, each of which is isomorphic to an element of , whose vertex sets partition . This proves a conjecture of Corsten and Mendonça in a strong form and generalises results on the multi‐colour Ramsey numbers of bounded‐degree bipartite graphs. It also settles the bipartite case of a general conjecture of Grinshpun and Sárközy.
Intrasession Caffeine Intake and Cycling Performance After Accumulated Work: A Field-Based Study
Authors: Sánchez-Redondo Iván R. , Alejo Lidia B. , Revuelta Carlos , de Pablos Raúl , Ibañez María , Pérez-López Alberto , Lucia Alejandro , Barranco-Gil David , Valenzuela Pedro L. 
Published: September 2024

Background: Preexercise caffeine intake has proven to exert ergogenic effects on cycling performance. However, whether these benefits are also observed under fatigue conditions remains largely unexplored. We aimed to assess the effect of caffeine ingested during prolonged cycling on subsequent time-trial performance in trained cyclists. Methods: The study followed a triple-blinded, randomized, placebo-controlled cross-over design. Eleven well-trained junior cyclists (17 ± 1 years) performed a field-based 8-min time trial under “fresh” conditions (i.e., after their usual warm-up) or after two work-matched steady-state cycling sessions (total energy expenditure∼20 kJ/kg and ∼100 min duration). During the latter sessions, participants consumed caffeine (3 mg/kg) or a placebo ∼60 min before the time trial. We assessed power output, heart rate, and rating of perceived exertion during the time trial and mood state (Brunel Mood Scale) before and after each session. Results: No significant condition effect was found for the mean power output attained during the time trial (365 ± 25, 369 ± 31, and 364 32 W for “fresh,” caffeine, and placebo condition, respectively; p = .669). Similar results were found for the mean heart rate (p = .100) and rating of perceived exertion (p = 1.000) during the time trial and for the different mood domains (all p > .1). Conclusions: Caffeine intake during prolonged exercise seems to exert no ergogenic effects on subsequent time-trial performance in junior cyclists. Future studies should determine whether significant effects can be found with larger caffeine doses or after greater fatigue levels.
Impact of obesity on clinical outcomes of methicillin-susceptible
Staphylococcus aureus
bloodstream infections
Authors: Wasielewski Anthony S. , Casapao Anthony M. , Jankowski Christopher A. , Isache Carmen L. , Ravi Malleswari , Kunz Coyne Ashlan J. 
Published: September 2024

ABSTRACT

Obesity affects over one-third of U.S. adults and complicates the treatment of methicillin-susceptible
Staphylococcus aureus
(MSSA) bloodstream infections (BSI). A study at the University of Florida Health Centers compared clinical outcomes between 233 obese and non-obese patients receiving cefazolin for MSSA BSI. No significant differences were found in clinical success (81.9% vs 82.7%), mortality (7.2% vs 5.3%), or adverse events (3.6% vs 3.3%). However, obese patients took longer to clear blood cultures (4.62 vs 4.01 days,
P
= 0.017).
Parametric and nonparametric population pharmacokinetic analysis of fluconazole in critically ill patients and dosing simulations for
Candida
infections
Authors: Matusik Elodie , Vassal Olivia , Conrad Anne , Ferry Tristan , Millet Aurélien , Dupont Damien , Grandjean Lola , Guitton Jérôme , Roux Sandrine , Bienvenu Anne-Lise , Bohé Julien , Friggeri Arnaud , Goutelle Sylvain 
Published: September 2024

ABSTRACT

Large pharmacokinetic (PK) variability of fluconazole has been reported in critically ill patients, but the implications for fluconazole dosing remain unclear. The objectives of this study were to evaluate the population PK of fluconazole and identify appropriate dosage regimens by simulations. This was a retrospective analysis of fluconazole PK data from patients hospitalized in critical care and infectious disease departments. Both parametric and nonparametric population approaches were used. Various loading and maintenance fluconazole doses were evaluated by simulations, with computation of the probabilities of PK/pharmacodynamic (PD) target attainment (PTA) and cumulative fractions of response (CFR) based on international and local minimum inhibitory concentration (MIC) distributions of
Candida
sp. Data from 36 critically ill patients and 16 non-critically ill patients were available for model building (
n
= 202 concentrations). The final model adequately described the data, including the external data set (13 patients). After 24 h of therapy, 65% and 74% of patients had trough and area under the concentration-time curve values below the usual targets. Standard dosages were associated with low PTA for MIC >1 mg/L at 24 h. Higher loading doses administered two times daily improved PTA. CFR were >90% for
C. albicans
with standard dosages, while they were very low for
C. glabrata
, even with high dosages.
Candida
species and associated MIC distributions strongly influence fluconazole dosage requirements. Higher loading doses may be necessary for the achievement of PK/PD targets up to MIC breakpoints. The use of fluconazole for invasive
C. glabrata
infection should be discouraged because of poor PK/PD target attainment.