bluuebunny/crossref_metadata_2025_split huggingface dataset:
Power allocation optimization strategy for multiple virtual power plants with diversified distributed flexibility resources
Authors: Qiu Zejian , Zhang Xin , Han Zhanyuan , Chen Fengchao , Luo Yuxin , Zhang Kuan 
Published: October 2024

AbstractThe virtual power plant integrating the flexible resources in the distribution network can provide additional adjustment capacity for the auxiliary services of distribution network. However, the actual internal situation of distribution network including insufficient adjustable capacity of energy storage, unreasonable power allocation, and voltage overrun leads to the difficulties in optimization scheduling. Therefore, this paper proposes a power allocation optimization strategy of distributed electricity‐H2 virtual power plants (EHVPPs) with aggregated flexible resources. Specifically, a distributed EHVPP division method based on the granular K‐medoids clustering algorithm is proposed to realize the independent autonomy and coordinated interaction between EHVPPs, and in order to quantify the operation and regulation capacity of distributed EHVPPs, an aggregation approach of regulating feasible domains of flexibility resources based on the improved zonotope approximations is developed. Moreover, a power allocation strategy based on the flexibility weight factor is proposed to handle the calculated minimum deviation between the total active output of PV and the dispatching power command, realizing the self‐consistency of distributed EHVPPs. Comparative studies have demonstrated the superior performance of the proposed methodology in economic merits and self‐consistency efficiency.
Severe and unclassifiable tremor
Authors: Serrano-Dueñas Marcos 
Published: October 2024

Abstract
Background Patients often exhibit very severe or disabling forms of tremor that cannot be clearly characterized.
Objective To present a series of 37 cases of tremor considered unclassifiable. Patients diagnosed with essential tremor according to criteria of the International Parkinson Disease and Movement Disorder Society (IPDMDS), who had been previously studied, were included as controls. All patients underwent a battery of tests between 2019 and 2022, which enabled us to compare them.
Methods Relevant demographic and clinical information were collected. The following tools were applied: the Mini-Mental State Examination (MMSE); the Hospital Anxiety and Depression Scale (HADS); the Fahn-Tolosa-Marín Tremor Rating Scale (TRS); and the Quality of Life in Essential Tremor (QUEST). A simple brain magnetic resonance imaging (MRI) scan was performed for all patients. The categorical variables were compared using the Chi-squared test and the t-test with Fisher correction if appropriate, and the quantitative variables were compared through the two-tailed Student t-test. Values of p ≤ 0.01 were considered statistically significant.
Results The cases presented higher scores on the anxiety and depression subscales of the HADS than the controls (p ≤ 0.006 and 0.000 respectively). In all domains of the TRS, the cases scored significantly higher, as well as in the QUEST. History of enolism was higher among the controls, and history of orthostasis and rest tremor was higher among the cases (p ≤ 0.000). Cerebellar atrophy was present in every patient in the case group, and in 24 subjects in the control group. Dystonia was observed in 7 subjects in the case group, and in none of the patients in the control group.
Conclusion There are patients with unclassifiable and extremely disabling tremors who respond poorly to the pharmacological therapy options.
Why should a 5q spinal muscular atrophy neonatal screening program be started?
Authors: Becker Michele Michelin , Nardes Flávia , Dangouloff Tamara , Servais Laurent , Araujo Alexandra Prufer de Queiroz Campos , Gurgel-Giannetti Juliana 
Published: October 2024

AbstractSpinal muscular atrophy (SMA) is a genetic neuromuscular progressive disorder that is currently treatable. The sooner the disease-modifying therapies are started, the better the prognosis. Newborn screening for SMA, which is already performed in many countries, has been scheduled to begin in the near future. The development of a well-organized program is paramount to achieve favorable outcomes for the child who is born with the disease and for the costs involved in health care. We herein present a review paper hoping to point out that SMA neonatal screening is urgent and will not increase the cost of its care.
Non-exercise Estimated Cardiorespiratory Fitness and Mortality Among Adults With Hypertension
Authors: Zhu Yong-Jian , Fu Wan-Rong , Lu Wen-Jie , Wang Xu-Le , Wang Xi , Shan Ying-Guang , Zheng Xiao-Lin , Li Ran , Peng Meng , Pan Liang , Qiu Jing , Qin Xiao-Fei , Sun Guo-Ju , Wang Lu , Dong Jian-Zeng , Xiao Li-Li , Qiu Chun-Guang 
Published: October 2024

Abstract

BACKGROUND
The non-exercise estimated cardiorespiratory fitness (eCRF) has been recognized as an important predictor of mortality among the general population. This study sought to evaluate the relationship between eCRF and mortality from all causes, cardiovascular disease (CVD), and cancer in hypertensive adults.

METHODS
We included 27,437 adults with hypertension from the National Health and Nutrition Examination Survey (NHANES) III and 10 NHANES cycles from 1999 to 2018. Multivariate Cox proportional hazard models were used to assess the hazard ratios and 95% confidence intervals (CIs) of eCRF for mortality.

RESULTS
A total of 8,023 deaths were recorded throughout a median 8.6-year follow-up, including 2,338 from CVD, and 1,761 from cancer. The eCRF with per 1 metabolic equivalent increase was linked to decreased risk of all-cause (adjusted HR 0.78, 95% CI: 0.75–0.81) and CVD mortality (adjusted HR 0.79, 95% CI: 0.74–0.84), rather than cancer mortality (adjusted HR 0.94, 95% CI: 0.86–1.03). Moreover, a stronger protective effect of eCRF was observed for females (HR 0.66 (95% CI: 0.62–0.72) versus HR 0.78 (95% CI: 0.73–0.83), Pinteraction &lt; 0.001 for all-cause mortality; HR 0.70 (95% CI: 0.61–0.80;) versus HR 0.82 (95% CI: 0.73–0.92), Pinteraction = 0.026 for CVD mortality) compared with males. Findings did not significantly differ in subgroup analyses and sensitivity analyses.

CONCLUSIONS
Among adults with hypertension, eCRF was inversely related to all-cause and CVD mortality, but not cancer mortality. A significant interaction effect existed between sex and eCRF. Further studies are needed to verify this association in different populations.
FormatAEG: a framework for bypassing ASLR defense and automated exploitation of format string vulnerability
Authors: Xu Shenglin , Jiang Zhiyuan , Wang Yongjun , Xie Peidai 
Published: October 2024

Abstract
The format string vulnerability is a common software vulnerability. A well-constructed format string can read and modify arbitrary memory addresses, causing serious system problems. Existing automated exploit generation solutions for format string vulnerability are unable to cope with the limitations imposed by the vulnerability defense mechanism Address Space Layout Randomization (ASLR) and the program itself on vulnerability exploitation. In this paper, to address the above challenges, we propose FormatAEG, the first automatic exploitation framework for format string vulnerabilities that can bypass ASLR defense and the program's own constraints. Specifically, we first proposed an arbitrary address reading and writing method based on a format string vulnerability, which can modify the target address data by directly arranging the target address or automatically searching and utilizing the pointer chain in the stack. Then, we propose a vulnerability reentry method based on global offset table (GOT) hijacking, which hijacks the program control flow by modifying function addresses in the GOT, making the vulnerability reentrant. In the experimental section, we evaluated FormatAEG using 20 Capture The Flag programs from top international tournaments and two real-world programs with format string vulnerabilities. The evaluation results show that with ASLR defense turned on, FormatAEG successfully detects format string vulnerability in 19 of these programs and generates exploit code for 15 of them. Compared with existing tools, FormatAEG detected 11 more format string vulnerabilities and generated 13 more exploit codes.
Probabilistic bias analysis for exposure misclassification of household income by neighbourhood in a cohort of individuals with colorectal cancer
Authors: Davis Laura E , Banack Hailey R , Calderon-Anyosa Renzo , Strumpf Erin C , Mahar Alyson L 
Published: October 2024

Abstract

Introduction
Despite poor agreement, neighbourhood income is used as a proxy for household income, due to a lack of data availability. We quantified misclassification between household and neighbourhood income and demonstrate quantitative bias analysis (QBA) in scenarios where only neighbourhood income is available in assessing income inequalities on colorectal cancer mortality.

Methods
This was a retrospective study of adults with colorectal cancer diagnosed 2006–14 from Statistics Canada’s Canadian Census Health and Environment Cohort. Neighbourhood income quintiles from Statistics Canada were used. Census household income quintiles were used to determine bias parameters and confirm results of the QBA. We calculated positive and negative predictive values using multinomial models, adjusting for age, sex and rural residence. Probabilistic QBA was conducted to explore the implication of exposure misclassification when estimating the effect of income on 5-year mortality.

Results
We found poor agreement between neighbourhood and household income: positive predictive values ranged from 21% to 37%. The bias-adjusted risk of neighbourhood income on 5-year mortality was similar to the risk of mortality by household income. The bias-adjusted relative risk of the lowest income quintile compared with the highest was 1.42 [95% simulation interval (SI) 1.32–1.53] compared with 1.46 [95% confidence interval (CI) 1.39–1.54] for household income and 1.18 (95% CI 1.12–1.24) for neighbourhood income.

Conclusion
QBA can be used to estimate adjusted effects of neighbourhood income on mortality which represent household income. The predictive values from our study can be applied to similar cohorts with only neighbourhood income to estimate the effects of household income on cancer mortality.
Barriers and facilitators of the use of clinical informatics resources to facilitate pharmacogenomic implementation in resource-limited settings
Authors: Bosic-Reiniger Jade , Martin James L , Brown Karen E , Anderson Heather D , Blackburn Hayley , Kao David P , Trinkley Katy E , Woodahl Erica L , Aquilante Christina L 
Published: October 2024

Abstract

Objective
Understand perceived barriers to and facilitators of using clinical informatics applications for pharmacogenomic (PGx) implementation in resource-limited settings.

Materials and Methods
We conducted a qualitative research study using a semi-structured interview guide informed by the Consolidated Framework for Implementation Research (CFIR). Interview questions assessed CFIR contextual determinants related to: electronic health record (EHR) infrastructure; clinical informatics personnel and resources; EHR integration of PGx test results; PGx clinical decision support (CDS) tools; institutional resources; and partner receptivity. Transcripts were coded and analyzed to identify themes.

Results
We interviewed 24 clinical informaticists and executive leaders working in rural or underserved health care settings in Montana (n = 15) and Colorado (n = 9) and identified three major themes: (1) EHR infrastructure limitations, (2) insufficient supporting resources, and (3) unique contextual considerations for resource-limited settings. EHR infrastructure limitations included limited agency related to EHR build and interoperability concerns. Theme 1 highlighted challenges associated with integrating structured data into the EHR and inadequate vendor support. Theme 2 included limited familiarity with PGx across the care team, cost concerns, and allocation of non-financial resources. Theme 3 highlighted perceptions about the clinical utility of PGx within rural and underrepresented populations. Potential facilitators, such as being able to act nimbly, were found to coexist among the reported barriers.

Discussion and Conclusion
Our results provide insight into the clinical informatics infrastructure in resource-limited settings and identify unique considerations for clinical informatics-facilitated PGx implementation. Future efforts in these settings should consider innovative partnerships and strategies to leverage facilitators and minimize barriers associated with integrating PGx CDS applications.
The impact of exogenous vasoactive intestinal polypeptide on inflammatory responses and mRNA expression of tight junction genes in lambs fed a high-grain diet
Authors: Mia Golam K , Hawley Emma , Yusuf Mustapha , Amat Samat , Ward Alison K , Keller Wanda L , Dorsam Glenn , Swanson Kendall C 
Published: October 2024

Abstract
This study assessed the impact of administering vasoactive intestinal polypeptide (VIP) on inflammation and intestinal VIP and tight junction mRNA expression in lambs fed grain-based finishing diets. Sixteen wether lambs (69.6 ± 1.9 kg) were individually housed, adapted to a corn-based diet containing no forage, and randomly assigned to 2 treatment groups. Lambs were intraperitoneally injected every other day for 28 d with either saline (0.9% NaCl) with no VIP (n = 8; control) or saline with VIP (n = 8; 1.3 nmol/kg BW). Blood samples were collected weekly for analysis of cytokine concentrations, and on days 0 and 28 for lipopolysaccharide (LPS), and LPS-binding protein (LBP) concentrations. Upon completion of the treatment period, lambs were euthanized and gastrointestinal tissues, including rumen, jejunum, cecum, and colon samples, were collected for analysis of the expression of tight junction mRNA (claudin-1, claudin-4, occludin, and ZO-1), endogenous VIP, and VIP receptor (VPAC-1). No treatment effects (P ≥ 0.38) were observed for VIP and VPAC-1 mRNA expression in the colon. Supplementation with VIP did not influence (P ≥ 0.28) the expression of claudin-1, claudin-4, occludin, and ZO-1 tight junction mRNA in the rumen, jejunum, cecum, and colon. Lambs treated with VIP had greater (P ≤ 0.01) plasma concentrations of the anti-inflammatory cytokines, IL-10 and IL-36RA. There were treatment-by-day interactions observed (P ≤ 0.02) for concentrations of the pro-inflammatory cytokines, MIP-1α and MIP-1β. Lambs that did not receive VIP had greater serum concentrations of LPS (P = 0.05) than the lambs receiving VIP. These data suggest that VIP administration may not influence tight junction mRNA expression but may decrease LPS concentrations and thus inflammation in lambs fed a grain-based diet.
Rare case of concomitant coronary artery bypass grafting and open abdominal aortic aneurysm repair
Authors: Pastore Dakota , Higgins Sabrina , James Taylor , Hooda Zamaan , Shenasen Pasha , Therionos Alexios , Bustamante John Paul , Beniwal Jagbir , Connolly Mark , Danks John 
Published: October 2024

Abstract
Coronary artery disease occurs when coronary vessels are unable to supply adequate oxygen to the myocardium, while an abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta. Both conditions have similar risk factors such as smoking and hypertension. If these disease processes become severe and are left untreated, life-threatening consequences may occur. We present a 71-year-old male with prior myocardial infarction and an infrarenal AAA that underwent a rare combined procedure of coronary artery bypass grafting (CABG) and open AAA repair surgery. The CABG involved grafting the left internal mammary artery and saphenous vein to coronary arteries while the AAA repair used an 18-mm bifurcated aortic graft. Combined CABG and open AAA repair is complex and rare, but aims to reduce mortality and prevent aneurysm rupture in patients with severe comorbid conditions. The patient’s positive postoperative outcome highlights the procedure’s efficacy in select cases.
The Effect of Online Music Therapy Interventions on Reducing Stress Levels in Small Hotel Managers: A Mixed-Methods Pilot Study
Authors: Dungsirisangthong Pichaya , Boonyam Treetip , Chiengchana Natee , Buranaprapuk Ampai 
Published: October 2024

Abstract
The rapidly changing business environment and increasing uncertainties due to the coronavirus disease 2019 pandemic since 2020 have led to heightened stress levels among managers. This study employed a mixed-method design to examine the effects of online music therapy interventions on reducing stress levels in small hotel managers. Thirteen managers participated in the online music therapy program, which consisted of six weekly music therapy sessions and self-guided music interventions for practice during the week. The music therapy interventions included music-assisted relaxation, improvisation, music listening with drawing, moving with music, song discussion, songwriting, and singing. The intake questionnaire collected participants’ demographic information and musical backgrounds. The Thai Perceived Stress Scale-10 (T-PSS-10) and Visual Analog Scale of Stress (VAS-S) were used to measure perceived stress levels. A paired t-test analysis compared the average participants’ perceived stress scores between pre and post-tests. Results demonstrated a significant reduction in perceived stress scores. Both the VAS-S for music therapy interventions and self-guided music interventions showed significant decreases after participation in each music therapy session and self-guided practice. In conclusion, online music therapy interventions can effectively reduce the perceived stress levels of managers facing uncertainty in small hotel businesses.
9New Materialism
Authors: Taylor Colleen 
Published: October 2024

Abstract
This review essay focuses on how the year’s work in new materialism builds on a vibrant discourse in literary studies and nascent, growing trends in postcolonial and indigenous new materialisms. A variety of new materialist works published in 2023, from the monographs Earthly Things: Immanence, New Materialisms, and Planetary Thinking and The Garden Politic: Global Plants and Botanical Nationalism in Nineteenth-Century America, to the journal article ‘New Materialism and Posthumanism in Roman Archaeology’, explore the ways in which the pillars of new materialist thought, such as the agentic capacity of vibrant matter, ‘speaking objects’, and entanglement, can lead to decolonial revelations about human culture and history. The essay is grouped according to common themes addressed in this year’s body of work: 1. Introduction; 2. Literature and Beyond; 3. Colonial Plants and Enslaved Objects; 4. New Materialism and Eco-Marxism; 5. Immanence and Planetary Thinking; 6. New (Materialist) Topics of Conversation in Science; and 7. Conclusion. The varied scholarship surveyed points to the conclusion that what was once seen as new materialism’s ethical weakness—its focus on matter over human beings—is now becoming a decolonial strength.
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
Authors: Richardson Miles , Zhao Shijie , Sheth Ravi U. , Lin Liyuan , Qu Yiming , Lee Jeongchan , Moody Thomas , Ricaurte Deirdre , Huang Yiming , Velez-Cortes Florencia , Urtecho Guillaume , Wang Harris H. 
Published: October 2024

ABSTRACTThe local arrangement of microbes can profoundly impact community assembly, function, and stability. To date, little is known about the spatial organization of the human gut microbiome. Here, we describe a high-throughput and streamlined method, dubbed SAMPL-seq, that samples microbial composition of micron-scale sub-communities with split-and-pool barcoding to capture spatial colocalization in a complex consortium. SAMPL-seq analysis of the gut microbiome of healthy humans identified bacterial taxa pairs that consistently co-occurred both over time and across multiple individuals. These colocalized microbes organize into spatially distinct groups or “spatial hubs” dominated byBacteroideceae,Ruminococceae, andLachnospiraceaefamilies. From a dietary perturbation using inulin, we observed reversible spatial rearrangement of the gut microbiome, where specific taxa form new local partnerships. Spatial metagenomics using SAMPL-seq can unlock new insights to improve the study of microbial communities.One Sentence SummaryHigh throughput micron-scale subcommunity sampling and sequencing identifies distinct spatial associations of gut bacteria within and across individuals.
Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy
Authors: Rahmaninejad Hadi , Xiao Yao , Tortora Maxime M.C. , Fudenberg Geoffrey 
Published: October 2024

AbstractIn mammalian interphase cells, genomes are folded by cohesin loop extrusion limited by directional CTCF barriers. This interplay leads to the enrichment of cohesin at barriers, isolation between neighboring topologically associating domains, and elevated contact frequency between convergent CTCF barriers across the genome. However, recentin vivomeasurements present a puzzle: reported residence times for CTCF on chromatin are in the range of a few minutes, while lifetimes for cohesin are much longer. Can the observed features of genome folding result from the action of relatively transient barriers? To address this question, we developed a dynamic barrier model, where CTCF sites switch between bound and unbound states with rates that can be directly compared with biophysical measurements. Using this model, we investigated how barrier dynamics would impact observables for a range of experimental genomic and imaging datasets, including ChIP-seq, Hi-C, and microscopy. We found the interplay of CTCF and cohesin binding timescales influence the strength of each of these features, leaving a signature of barrier dynamics even in the population-averaged snapshots offered by genomic datasets. First, in addition to barrier occupancy, barrier bound times are crucial for instructing features of genome folding. Second, the ratio of boundary to extruder lifetime greatly alters simulated ChIP-seq and simulated Hi-C. Third, large-scale changes in chromosome morphology observed experimentally after increasing extruder lifetime require dynamic barriers. By integrating multiple sources of experimental data, our biophysical model argues that CTCF barrier bound times effectively approach those of cohesin extruder lifetimes. Together, we demonstrate how models that are informed by biophysically measured protein dynamics broaden our understanding of genome folding.