bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small Cell Variant of Renal Oncocytoma – a Case Report of Unusual Histopathologic Entity
Authors: Bartoš Vladimír 
Published: October 2017

Renal oncocytoma (RO) accounts for 3–7% of all renal cells tumors. It typically consistes of large eosinophilic cells (oncocytes) with abundant cytoplasm, which constitute the crucial diagnostic feature. In 2001, the Czeck authors first described an unusual small cell variant of RO and untill now, only a few reports of such cases have been published. In the current article, the author presents an additional new case. 40-year old male with macroscopic hematuria as a clinical symptom was diagnosed to have solitary tumor in the upper third of the right kidney. He underwent a nephrectomy. On light microscopy, the tumor was predominantly composed of uniform small cells („oncoblasts“) with scant cytoplasm, hyperchromic nuclei and high nuclear-to-cytoplasmic ratio. In addition, it also contained characteristic oncocytes typical for oncocytoma. Tumor was strongly immunoreactive for EMA, sporadically positive for CK7 and negative for RCC antigen, vimentin, S100, WT1, chromogranin and synaptophysin. Proliferative activity did not exceed 1% and mitotic activity was virtually absent. No necrosis or aggressive growth features were found. The spectrum of histopathologic and immunohistochemical findings was consistent with a diagnosis of small cell variant of RO. The author focus on histopathological aspects and differential diagnostic pitfalls of this unique lesion.
Peculiarities of Teaching Problems of Metabolic Syndrome in Children to Interns
Authors: Bobrykovych Olha 
Published: October 2017

Obesity has become one of the most urgent social problems worldwide. Continuous and rapid increase in obesity rates is considered by the World Health Organization as a global epidemic. Obesity affects children as well; the World Health Organization recognized childhood obesity as an acute public health crisis. Childhood obesity is often accompanied by arterial hypertension, hyperlipidemia and disorders of carbohydrate metabolism resulting in symptom complex – metabolic syndrome. While teaching the problems of metabolic syndrome in children to interns, a significant attention is paid to risk factors, diagnosis, treatment and prevention of syndrome. Such approach will allow future pediatricians to diagnose and prevent the development of early complications of metabolic syndrome in children timely.
Natural durability and dimensional stability of white mulberry (Morus alba L.) for Middle Eastern lutes
Authors: Se Golpayegani Aida , THEVENON Marie-France , Bremaud Iris , Pourtahmasi Kambiz , Gril Joseph 
Published: October 2017

Instrument makers prefer wood species which not only have excellent acoustical properties, but also tend to keep their natural state when going through preparations and pretreatments. In this study long time water soaking, a common protocol among Iranian lute makers, was used to investigate the natural durability and dimensional stability of White mulberry (Morus alba L.). The wood of white mulberry, which is the only source for making Iranian lutes for more than a century, was examined for its natural resistance towards fungi and termites. Samples were also studied for their dimensional change during four months of water soaking. White mulberry, whether leached or unleached, showed to be a very resistant species towards both termites and fungi. Gradual removal of the extractives during water immersion resulted in an increase in partial shrinkage. It was concluded that water leaching, though not affecting the natural durability, tends to reduce the dimensional stability of white mulberry.
INVESTIGATING STOCK MARKET REACTION ON JAKARTA ISLAMIC INDEX (JII) ANNOUNCEMENT
Authors: Laila Nisful , Nasih Mohammad 
Published: October 2017

The aim of this research is to investigate the stock market reaction from the event when Jakarta Islamic Index (JII) is announced. The indication of stock market reaction was shown by appearing abnormal return during the date when the emiten are in the list of JII, and also several days before and after the annaouncement day. The method of this research is called event studies. Data collected from daily stock price from Indonesian Stock Exchange data base. By using market adjusted model, it was found that 21 stocks from JII latest list, during 11 days observation shown significant abnormal return, at 5% significant level. The conclusion from this finding is that the information of JII announcement has important content that caused the abnormal return during and around the announcement day. Moreover the information is shown a positive signal for investor, so that caused positive abnormal return
PENGARUH INVESTASI DAN TENAGA KERJA TERHADAP PRODUK DOMESTIK REGIONAL BRUTO (PDRB) DAN PENDAPATAN ASLI DAERAH (PAD) KOTA BALIKPAPAN
Authors: Rosmalia Johana , Iskandar Rusdiah , Fitriadi Fitriadi 
Published: October 2017

This study used secondary data in the form of time series which are analyzed using Pathway analysis with multiple linear regression formula. The purpose of this study was to determine the effect of investment and labor to gross regional domestic product (GRDP) and regional revenues in Balikpapan city. The results of the study was shown that Y = 0.202 - 0.098 X1 + 0.244 X2 + 0.825 X3. The results showed that investment, labor and gross regional domestic product (GRDP) have jointly effect on the regional revenues in Balikpapan city. Partially; the investment has no significant effect on gross regional domestic product (GRDP), labor has significant effect on gross regional domestic product (GRDP), gross regional domestic product (GRDP) has significant effect to regional revenues in Balikpapan city, the investment has no significant effect on regional revenues in Balikpapan city, and labor has no significant effect on regional revenues in Balikpapan city. The contribution of investment, labor and gross regional domestic product (GRDP) variable was about 93.5 % and it means that those have very strong relationship; meanwhile, the rest, about 6.5 %, has been influenced by other factors.
Irrigação por gotejamento e manejo do fósforo no progresso da ferrugem do cafeeiro
Authors: Barbosa Junior Mauro Peraro , Pozza Edson Ampélio , Souza Paulo Estevão de , Silva Mirian De Lourdes Oliveira e , Pozza Adélia Aziz Alexandre , Guimarães Rubens José 
Published: October 2017

<p>A ferrugem é a principal doença do cafeeiro, sendo sua ocorrência e intensidade afetada em razão do fornecimento de água e equilíbrio nutricional das plantas. Dessa forma objetivou-se avaliar a incidência da ferrugem, em lavoura cafeeira com diferentes manejos de irrigação e adubação. O estudo foi realizado em Lavras-MG, em cafeeiro da cultivar MGS Travessia. As avaliações da doença foram realizadas no período de março de 2012 a novembro de 2014. O delineamento experimental foi em blocos casualizados, com doze tratamentos, sendo 3 manejos de adubação, 4 manejos de irrigação e 3 repetições, totalizando 36 parcelas. O resultado referente a media da incidência da doença durante o período avaliado foi plotado em gráfico. Os dados de incidência foram integrados em área abaixo da curva de progresso da doença (AACPIF). Foi observada maior AACPIF (P&lt;0,05) no tratamento sem irrigação no ano de 2013. A ausência da adubação com fósforo também proporcionou maior progresso da ferrugem. </p>
Musculoskeletal Pain in Children and Adolescents: A Way Forward
Authors: Kamper Steven J. , Williams Christopher M. 
Published: October 2017

There are substantial gaps in our understanding of musculoskeletal pain in children and adolescents. While there are challenges to performing research in this space, the prevalence, burden, and lack of available evidence to inform clinical practice mean that overcoming these challenges is important. The editors see the collection of work in this special issue as a step in the right direction. J Orthop Sports Phys Ther 2017;47(10):702–704. doi:10.2519/jospt.2017.0109
Lumbar Spine Osteomyelitis in an Adolescent Girl With Nonspecific Low Back Pain
Authors: Wall Christopher M. , Paterno Mark V. , Sturm Peter F. 
Published: October 2017

A 13-year-old adolescent girl presented to the emergency department with low back pain of acute onset after bending forward. Lumbar spine radiographs were taken and found to be unremarkable, and the patient was referred to physical therapy. Following examination, the patient was referred to her physician for a suspected nonmechanical cause. Magnetic resonance imaging assessment revealed L3-4 discitis, with osteomyelitis extending into the adjacent right iliopsoas muscle. Further testing and bone biopsy confirmed osteomyelitis. J Orthop Sports Phys Ther 2017;47(10):814. doi:10.2519/jospt.2017.6883
Resection of posterior clinoid meningioma through retrosigmoid approach: concepts and nuances
Authors: Nanda Anil , Patra Devi Prasad , Savardekar Amey , Maiti Tanmoy K. , Kalakoti Piyush 
Published: October 2017

Meningiomas arising from the posterior clinoid process pose a great surgical challenge because of their location and propensity to cause critical neurovascular compression. The authors’ patient was a 66-year-old female who had a large posterior clinoid meningioma with significant brainstem compression that was operated on through the retrosigmoid approach. This 3D surgical video emphasizes the various technical concepts that are important to preserving compressed neural and vascular structures during the surgery. It would also be interesting to note the extent of visualization around the posterior clinoid region gained through a retrosigmoid corridor.The video can be found here: https://youtu.be/CBmT_0ov0YA.
Combined petrosal approach for petroclival meningioma
Authors: Arnaout Omar , Al-Mefty Ossama 
Published: October 2017

The authors present the case of a 56-year-old patient who presented with a large petroclival meningioma and clinical symptoms of brainstem compression and hydrocephalus. The authors describe a two-stage combined petrosal approach for complete resection of the tumor. The nuances of the approach and microsurgical technique are discussed, as well as the radiographic and clinical outcomes.The video can be found here: https://youtu.be/T90vUIPKQsA.
Endoscopic endonasal pituitary gland hemi-transposition for resection of a dorsum sellae meningioma
Authors: Montaser Alaa S. , Revuelta Barbero Juan M. , Todeschini Alexandre , Beer-Furlan André , Lonser Russell R. , Carrau Ricardo L. , Prevedello Daniel M. 
Published: October 2017

A 69-year-old female with incidental diagnosis of a dorsum sellae meningioma had shown significant tumor growth after initial conservative management. The procedure started with a microscopic sublabial transsphenoidal approach to the sella and the suprasellar space. Due to limitations to a safe dissection and removal of the retrosellar component, the surgery was converted to a purely endoscopic endonasal approach with left hemi-transposition of the pituitary gland, followed by drilling of the dorsum sellae and removal of the left posterior clinoid process. A complete tumor resection was achieved, and a multilayer skull base reconstruction was performed without complications.The video can be found here: https://youtu.be/BEolyK-To_A.
Extended middle fossa approach with anterior petrosectomy for resection of upper petroclival meningioma involving Meckel’s cave: operative video and technical nuances
Authors: Liu James K. 
Published: October 2017

The surgical management of petroclival meningiomas remains a formidable challenge. These tumors are deep in the base of the skull and arise medial to the fifth cranial nerve. In this operative video, the author demonstrates the extended middle fossa approach with anterior petrosectomy to resect an upper petroclival meningioma extending into Meckel’s cave with brainstem compression. This approach is very useful for accessing deep tumors located above and below the tentorium, and between the fifth and seventh cranial nerves. Access to Meckel’s cave is readily achieved by opening the fibrous ring of the porous trigeminus. This video demonstrates the operative technique and surgical nuances of the skull base approach, useful anatomic landmarks of the middle fossa rhomboid for safe petrosectomy drilling, pearls for cranial nerve and neuro-otologic preservation, and exposure of Meckel’s cave. A gross-total resection was achieved, and the patient was neurologically intact. In summary, the extended middle fossa approach with anterior petrosectomy is an important strategy in the armamentarium for surgical management of petroclival meningiomas.The video can be found here: https://youtu.be/jttwJIYPHC8.
Extradural clinoidectomy for resection of clinoidal meningioma
Authors: Buttrick Simon , Morcos Jacques J. , Elhammady Mohamed S. , Wang Anthony C. 
Published: October 2017

Extradural anterior clinoidectomy is a versatile technique to increase exposure of the sellar and parasellar region. It is of particular use in the resection of clinoidal meningiomas, as sphenoidal and clinoidal hyperostosis can cause compression of the optic nerve. Extradural clinoidectomy follows a series of steps, consisting of (1) unroofing of the superior orbital fissure, (2) unroofing of the optic canal, (3) removal of the optic strut, and (4) removal of the anterior clinoid process. The authors show these steps in detail, as well as their application to the resection of a large clinoidal meningioma.The video can be found here: https://youtu.be/O1Fcef29ETg.
Resection of middle petroclival meningioma via combined anterior transpetrosal and retrosigmoid approaches at two separate stages: 3D operative video
Authors: Dogan Ihsan , Ocak Pinar Eser , Pyle G. Mark , Başkaya Mustafa K. 
Published: October 2017

Surgical access to the petroclival region poses a challenge to neurosurgeons. A wide range of approaches has been demonstrated in the past. In this video, the authors present a 69-year-old male patient who presented with 3-month history of worsening left-sided numbness. The tumor was totally removed in 2 sessions via anterior transpetrosal and retrosigmoid approaches, respectively. The authors demonstrate 2 separate skull base approaches to resect a petroclival meningioma and discuss pitfalls and problems of management for challenging meningiomas. The authors suggest that surgical approaches to petroclival meningiomas should be selected based on an individual case. A skull base team should be versatile in performing all these approaches.The video can be found here: https://youtu.be/BCVrn3TeNvE.
Introduction: surgical management of skull base meningiomas
Authors: Zada Gabriel , Başkaya Mustafa K , Shah Mitesh V. 
Published: October 2017

Meningiomas represent the most common primary intracranial neoplasm treated by neurosurgeons. Although multimodal treatment of meningiomas includes surgery, radiation-based treatments, and occasionally medical therapy, surgery remains the mainstay of treatment for most symptomatic meningiomas. Because of the intricate relationship of the dura mater and arachnoid mater with the central nervous system and cranial nerves, meningiomas can arise anywhere along the skull base or convexities, and occasionally even within the ventricular system, thereby mandating a catalog of surgical approaches that neurosurgeons may employ to individualize treatment for patients. Skull base meningiomas represent some of the most challenging pathology encountered by neurosurgeons, on account of their depth, invasion, vascularity, texture/consistency, and their relationship to bony anatomy, cranial nerves, and blood vessels. Resection of complex skull base meningiomas often mandates adequate bony removal to achieve sufficient exposure of the tumor and surrounding region, in order to minimize brain retraction and optimally identify, protect, control, and manipulate sensitive neurovascular structures. A variety of traditional skull base approaches has evolved to address complex skull base tumors, of which meningiomas are considered the paragon in terms of both complexity and frequency.In this supplemental video issue of Neurosurgical Focus, contributing authors from around the world provide instructional narratives demonstrating resection of a variety of skull base meningiomas arising from traditionally challenging origins, including the clinoid processes, tuberculum sellae, dorsum sellae, petroclival region, falco-tentorial region, cerebellopontine angle, and foramen magnum. In addition, two cases of extended endoscopic endonasal approaches for tuberculum sellae and dorsum sellae meningiomas are presented, representing the latest evolution in accessing the skull base for selected tumors. Along with key pearls for safe tumor resection, an equally important component of open and endoscopic skull base operations for meningiomas addressed by the contributing authors is the reconstruction aspect, which must be performed meticulously to prevent delayed cerebrospinal fluid leakage and/or infections. This curated assortment of instructional videos represents the authors’ optimal treatment paradigms pertaining to the selection of approach, setup, exposure, and principles to guide tumor resection for a wide spectrum of complex meningiomas.
Adolescent idiopathic scoliosis: risk factors for complications and the effect of hospital volume on outcomes
Authors: Menger Richard P. , Kalakoti Piyush , Pugely Andrew J. , Nanda Anil , Sin Anthony 
Published: October 2017

OBJECTIVEAdolescent idiopathic scoliosis (AIS) is the most common form of scoliosis. Limited literature exists defining risk factors associated with outcomes during initial hospitalization in these patients. In this study, the authors investigated patient demographics, clinical and hospital characteristics impacting short-term outcomes, and costs in adolescent patients undergoing surgical deformity correction for idiopathic scoliosis. Additionally, the authors elucidate the impact of hospital surgical volume on outcomes for these patients.METHODSUsing the National Inpatient Sample database and appropriate International Classification of Diseases, 9th Revision codes, the authors identified adolescent patients (10–19 years of age) undergoing surgical deformity correction for idiopathic scoliosis during 2001–2014. For national estimates, appropriate weights provided by the Agency of Healthcare Research and Quality were used. Multivariable regression techniques were employed to assess the association of risk factors with discharge disposition, postsurgical neurological complications, length of hospital stay, and hospitalization costs.RESULTSOverall, 75,106 adolescent patients underwent surgical deformity correction. The rates of postsurgical complications were estimated at 0.9% for neurological issues, 2.8% for respiratory complications, 0.8% for cardiac complications, 0.4% for infections, 2.7% for gastrointestinal complications, 0.1% for venous thromboembolic events, and 0.1% for acute renal failure. Overall, patients stayed at the hospital for an average of 5.72 days (median 5 days) and on average incurred hospitalization costs estimated at $54,997 (median $47,909). As compared with patients at low-volume centers (≤ 50 operations/year), those undergoing surgical deformity correction at high-volume centers (> 50/year) had a significantly lower likelihood of an unfavorable discharge (discharge to rehabilitation) (OR 1.16, 95% CI 1.03–1.30, p = 0.016) and incurred lower costs (mean $33,462 vs $56,436, p < 0.001) but had a longer duration of stay (mean 6 vs 5.65 days, p = 0.002). In terms of neurological complications, no significant differences in the odds ratios were noted between high- and low-volume centers (OR 1.23, 95% CI 0.97–1.55, p = 0.091).CONCLUSIONSThis study provides insight into the clinical characteristics of AIS patients and their postoperative outcomes following deformity correction as they relate to hospital volume. It provides information regarding independent risk factors for unfavorable discharge and neurological complications following surgery for AIS. The proposed estimates could be used as an adjunct to clinical judgment in presurgical planning, risk stratification, and cost containment.
Temporary occipital fixation in young children with severe cervical-thoracic spinal deformity
Authors: Kelley Brian J. , Minkara Anas A. , Angevine Peter D. , Vitale Michael G. , Lenke Lawrence G. , Anderson Richard C. E. 
Published: October 2017

OBJECTIVEThe long-term effects of instrumentation and fusion of the occipital-cervical-thoracic spine on spinal growth in young children are poorly understood. To mitigate the effects of this surgery on the growing pediatric spine, the authors report a novel technique used in 4 children with severe cervical-thoracic instability. These patients underwent instrumentation from the occiput to the upper thoracic region for stabilization, but without bone graft at the craniovertebral junction (CVJ). Subsequent surgery was then performed to remove the occipital instrumentation, thereby allowing further growth and increased motion across the CVJ.METHODSThree very young children (15, 30, and 30 months old) underwent occipital to thoracic posterior segmental instrumentation due to cervical or upper thoracic dislocation, progressive kyphosis, and myelopathy. The fourth child (10 years old) underwent similar instrumentation for progressive cervical-thoracic scoliosis. Bone graft was placed at and distal to C-2 only. After follow-up CT scans demonstrated posterior arthrodesis without unintended fusion from the occiput to C-2, 3 patients underwent removal of the occipital instrumentation.RESULTSFollow-up cervical spine flexion/extension radiographs demonstrated partial restoration of motion at the CVJ. One patient has not had the occipital instrumentation removed yet, because only 4 months have elapsed since her operation.CONCLUSIONSTemporary fixation to the occiput provides increased biomechanical stability for spinal stabilization in young children, without permanently eliminating motion and growth at the CVJ. This technique can be considered in children who require longer instrumentation constructs for temporary stabilization, but who only need fusion in more limited areas where spinal instability exists.
Evaluation and management of adolescent idiopathic scoliosis: a review
Authors: Jada Ajit , Mackel Charles E. , Hwang Steven W. , Samdani Amer F. , Stephen James H. , Bennett James T. , Baaj Ali A. 
Published: October 2017

Adolescent idiopathic scoliosis (AIS) is a 3D spinal deformity affecting children between the ages of 11 and 18, without an identifiable etiology. The authors here reviewed the available literature to provide spine surgeons with a summary and update on current management options.Smaller thoracic and thoracolumbar curves can be managed conservatively with observation or bracing, but corrective surgery may be indicated for rapidly growing or larger curves. The authors summarize the atypical features to look for in patients who may warrant further investigation with MRI during diagnosis and review the fundamental principles of the surgical management of AIS.Patients with AIS can be managed very well with a combination of conservative and surgical options. Outcomes for these children are excellent with sustained longer-term results.