bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic Outcomes in Children With Congenital Heart Defects
Authors: Oster Matthew E. , Watkins Stephanie , Hill Kevin D. , Knight Jessica H. , Meyer Robert E. 
Published: February 2017

Background—
Most studies evaluating neurocognitive outcomes in children with congenital heart defects (CHD) have focused on high-risk patients or used specialized, resource-intensive testing. To determine the association of CHD with academic outcomes and compare outcomes according to the severity of CHD, we linked state educational records with a birth defects registry and birth certificates.

Methods and Results—
We performed a retrospective cohort study using data from the North Carolina Birth Defects Monitoring Program, North Carolina Department of Public Instruction, and North Carolina Department of Health and Human Services vital records. We performed logistic regression, adjusting for maternal education, race/ethnicity, enrollment in public pre-Kindergarten, and gestational age, to determine the association of CHD with not meeting standards on reading and math end-of-grade examinations in third grade in 2006 to 2012. Of 5624 subjects with CHD and 10 832 with no structural birth defects, 2807 (50%) and 6355 (59%) were linked, respectively. Children with CHD had 1.24× the odds of not meeting standards in either reading or math (95% confidence interval, 1.12–1.37), with 44.6% of children with CHD not meeting standards in at least one of these areas compared with 37.5% without CHD. Although children with both critical and noncritical CHD had poorer outcomes, those with critical CHD were significantly more likely to receive exceptional services compared with the noncritical group (adjusted odds ratio, 1.46; 95% confidence interval, 1.15–1.86).

Conclusions—
Children with all types of CHD have poorer academic outcomes compared with their peers. Evaluation for exceptional services should be considered in children with any type of CHD.
African American Stroke Survivors
Authors: Skolarus Lesli E. , Freedman Vicki A. , Feng Chunyang , Burke James F. 
Published: February 2017

Background—
Blacks have higher stroke incidence and experience greater poststroke disability than whites. To optimize care for stroke survivors, it is important to understand the amount of care that they receive and the implications for stroke caregivers.

Methods and Results—

Data from 2 nationally representative, population-based studies, the NHATS (National Health and Aging Trends Study) linked to the NSOC (National Study of Caregiving), were used to identify elderly stroke survivors and their caregivers. We compared hours of care received and unmet activity need among the 581 white and 225 black stroke survivors. We then performed racial comparisons of positive and negative aspects of caregiving reported by caregivers of black and white stroke survivors. Black stroke survivors were more likely than white stroke survivors to have a caregiver (62.5% versus 49.7%;
P
<0.01) and received on average more hours of help per week (31.7 versus 20.5;
P
<0.01). There was little racial difference in unmet need for assistance. Caregivers of black stroke survivors reported more positive aspects of caregiving than caregivers of white stroke survivors (6.8 versus 6.0;
P
<0.01). There was no racial difference in negative aspects of caregiving, depression, or anxiety.

Conclusions—
Black stroke survivors received an average of ≈11 more hours of care than white stroke survivors without substantial differences in unmet need. Despite providing more hours of care, caregivers of black stroke were more positive about their caregiver role than caregivers of white stroke survivors.
Impaired Health Status, Psychological Distress, and Personality in Women and Men With Nonobstructive Coronary Artery Disease
Authors: Mommersteeg Paula M.C. , Arts Lindy , Zijlstra Wobbe , Widdershoven Jos W. , Aarnoudse Wilbert , Denollet Johan 
Published: February 2017

Background—
Patients with nonobstructive coronary artery disease (NOCAD; wall irregularities, stenosis <60%), and women with NOCAD in particular, remain underinvestigated. We examined sex and gender (S&G) differences in health status, psychological distress, and personality between patients with NOCAD and the general population, as well as S&G differences within the NOCAD population.

Methods and Results—
In total, 523 patients with NOCAD (61±9 years, 52% women) were included via coronary angiography and computed tomography as part of the TWIST (Tweesteden Mild Stenosis) study. Generic health status (12-item Short Form physical and mental scales and fatigue), psychological distress (Hospital Anxiety and Depression Scale anxiety and depressive symptoms and Global Mood Scale negative and positive affect), and personality (Type D personality) were compared between patients with NOCAD and an age- and sex-matched group of 1347 people from the general population. Frequency matching was performed to obtain a similar sex distribution in each age–decile group. Both men and women with NOCAD reported impaired health status, more psychological distress, and Type D personality compared with men and women in the reference group. Women reported more psychosocial distress compared with men, but no significant sex-by-group interaction effects were observed. Women with NOCAD reported impaired health status, more anxiety, and less positive affect, but no differences in depressive symptoms, angina, or Type D personality when compared with men with NOCAD. Age, education, employment, partner, and alcohol use explained these S&G differences within the NOCAD group.

Conclusions—
In both men and women, NOCAD was associated with impaired health status, more psychological distress, and Type D personality when compared with a reference population. Factors reflecting S&G differences explained these S&G findings in patient-reported outcomes.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01788241.
Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction
Authors: Lu Yuan , Zhou Shengfan , Dreyer Rachel P. , Spatz Erica S. , Geda Mary , Lorenze Nancy P. , D’Onofrio Gail , Lichtman Judith H. , Spertus John A. , Ridker Paul M. , Krumholz Harlan M. 
Published: February 2017

Background—
Young women (≤55 years of age) with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. Elevated inflammatory markers are associated with an increased risk of cardiovascular outcomes after AMI, but little is known about whether young women have higher inflammatory levels after AMI compared with young men.

Methods and Results—
We assessed sex differences in post-AMI inflammatory markers and whether such differences account for sex differences in 12-month health status, using data from 2219 adults with AMI, 18 to 55 years of age, in the United States. Inflammatory markers including high-sensitivity C-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 were measured 1 month after AMI. Overall, women had higher levels of hsCRP and lipoprotein-associated phospholipase A2 after AMI compared with men, and this remained statistically significant after multivariable adjustment. Regression analyses showed that elevated 1-month hsCRP was associated with poor health status (symptom, function, and quality of life) at 12 months. However, the association between hsCRP and health status became nonsignificant after adjustment for sociodemographics, comorbidities, and treatment factors. Half of these patients had residual inflammatory risk (hsCRP >3 mg/L) compared with a third who had residual cholesterol risk (Low-density lipoprotein cholesterol >100 mg/dL).

Conclusions—
Young women with AMI had higher inflammatory levels compared with young men. Elevated 1-month hsCRP was associated with poor health status at 12 months after AMI, but this was attenuated after adjustment for patient characteristics. Targeted anti-inflammatory treatments are worthy of consideration for secondary prevention in these patients if ongoing trials of anti-inflammatory therapy prove effective.
Dealings with ccp and kmt in British Hong Kong: The Shanghai Bankers, 1948–1951 (在英屬香港面對中國共產黨和中國國民黨──上海銀行家的抉擇與挑戰,1948〜1951年)
Authors: Lee (李培德) Pui-Tak 
Published: February 2017

The year 1949 was a great divide in modern Chinese history. How Shanghai bankers responded to it is an interesting question to address. For those bankers who chose to leave Shanghai and settle in British Hong Kong, can we suppose they were permanently separated from China or Taiwan? It is generally assumed that once the Shanghai bankers confined themselves to their new home in Hong Kong or moved on to other locations in the United States or elsewhere, they immediately severed all ties with either mainland China under the ccp (Chinese Communist Party) or Taiwan under the kmt (Kuomintang or Guomindang). Such an assumption leads to a mistaken argument that the departure of Chinese bankers from Shanghai cut short their involvements in China politics. Perhaps it is true that some emigrant bankers never returned, but others remained in touch with their home in China, whether because they were solicited by the agents who were sent to the colony by the ccp in China and the kmt in Taiwan, or, because they took the initiative in reaching across the borders to mainland China or Taiwan. From their sanctuary in Hong Kong, how did the bankers conduct cross-border relations after 1949?
This paper will go beyond the general assumption that the Shanghai bankers turned to Hong Kong solely for the colony’s being a sanctuary during the political and economic turmoil of the 1940s. Instead, these bankers continued to engage in political confrontation to the ccp and the kmt after they fled Shanghai. This paper argues that once they were in the colony, they had to address several problems. These included, first, to choose their final destination in either Shanghai, Hong Kong or Taipei; second, whether to continue or quit their banking careers and thirdly, to find a solution in order to counteract the alignment with either the ccp or the kmt.
1949年是中國近代史的分水嶺，上海銀行家對面對動盪不安的局勢會作出怎樣的回應，是一個很值得討論的問題。一旦銀行家選擇離開上海，轉移到英屬香港，他們就可完全脫離國共內戰的地理範疇──中國大陸或臺灣嗎？一般的研究無不認為已從香港轉移到香港的上海銀行家，目的為遠離包括在大陸執政的中國共產黨或撤退至臺灣的國民黨。本文指出，這樣的設想是對當時處於動盪政治經濟局勢的上海銀行家的錯誤理解。事實上，當時是有一部份從上海撤離的銀行家並不願意再被捲入政治，但是有更多已在境外的銀行家，透過自己在國共兩黨的代表，與中國大陸或臺灣保持緊密之聯繫，也有許多銀行家是主動地發展出跨境的管道來維持與中國大陸或臺灣的關係。值得探討的是，1949年之後，這些以英屬香港為基地的跨境聯繫是如何運作的呢？
本文探討1940年代末在中國變動的政治與經濟局勢下，香港不僅為離開上海的銀行家提供一個安全的庇護所，同時更是這些銀行家在離開上海後繼續面對中國共產黨和國民黨，進行各種活動的最重要境外基地。本文指出這些上海銀行家在移居香港之際所要面對的諸多問題。首先，如何在上海、香港和臺北三地之間作出選擇，哪裏是他們最佳的落腳處？其次，是否要繼續和如何維持銀行的業務？最後，應如何因應中國共產黨和中國國民黨向他們的統戰而作出適當的反應？ (This article is in English).
Molecular phylogeny of the tribe Torini Karaman, 1971 (Actinopterygii: Cypriniformes) from the Middle East and North Africa
Authors: BORKENHAGEN KAI 
Published: February 2017

Freshwater fishes of the cyprinid tribe Torini are widespread in Africa the Middle East and Indomalaya. The relationships of Middle-Eastern Torini are analysed based on mitochondrial markers (Cyt b, ND4) of the majority of relevant species. I present a larely well resolved phylogeny, which confirms the validity of the morphologically defined genera Arabibarbus, Carasobarbus, Mesopotamichthys and Pterocapoeta. The Torini originated in Indomalaya and colonised Africa via the Middle East. Morocco was colonised two times independently, first from sub-Saharan Africa and secondly along the southern margin of the Mediterranean Sea. The Tigris–Euphrates system is an important crossroad for the colonisation of the Jordan River, the Orontes River and the watercourses of the Arabian Peninsula by freshwater fishes. The Jordan lost its connection to the Euphrates earlier than the Orontes. The Arabian Peninsula was colonised from the Tigris–Euphrates system in at least two independent events.
The Central Role of Ocean Dynamics in Connecting the North Atlantic Oscillation to the Extratropical Component of the Atlantic Multidecadal Oscillation
Authors: Delworth Thomas L. , Zeng Fanrong , Zhang Liping , Zhang Rong , Vecchi Gabriel A. , Yang Xiaosong 
Published: February 2017

Abstract
The relationship between the North Atlantic Oscillation (NAO) and Atlantic sea surface temperature (SST) variability is investigated using models and observations. Coupled climate models are used in which the ocean component is either a fully dynamic ocean or a slab ocean with no resolved ocean heat transport. On time scales less than 10 yr, NAO variations drive a tripole pattern of SST anomalies in both observations and models. This SST pattern is a direct response of the ocean mixed layer to turbulent surface heat flux anomalies associated with the NAO. On time scales longer than 10 yr, a similar relationship exists between the NAO and the tripole pattern of SST anomalies in models with a slab ocean. A different relationship exists both for the observations and for models with a dynamic ocean. In these models, a positive (negative) NAO anomaly leads, after a decadal-scale lag, to a monopole pattern of warming (cooling) that resembles the Atlantic multidecadal oscillation (AMO), although with smaller-than-observed amplitudes of tropical SST anomalies. Ocean dynamics are critical to this decadal-scale response in the models. The simulated Atlantic meridional overturning circulation (AMOC) strengthens (weakens) in response to a prolonged positive (negative) phase of the NAO, thereby enhancing (decreasing) poleward heat transport, leading to broad-scale warming (cooling). Additional simulations are used in which heat flux anomalies derived from observed NAO variations from 1901 to 2014 are applied to the ocean component of coupled models. It is shown that ocean dynamics allow models to reproduce important aspects of the observed AMO, mainly in the Subpolar Gyre.
A Simple Model of the Life Cycle of Mesoscale Convective Systems Cloud Shield in the Tropics
Authors: Roca R. , Fiolleau T. , Bouniol D. 
Published: February 2017

Abstract
Mesoscale convective systems (MCSs) are important to the water and energy budget of the tropical climate and are essential ingredients of the tropical circulation. MCSs are readily observed in satellite infrared geostationary imagery as cloud clusters that evolve in time from small structures to well-organized large patches of cloud shield before dissipating. The MCS cloud shield is the result of a large ensemble of mesoscale dynamical, thermodynamical, and microphysical processes. This study shows that a simple parametric model can summarize the time evolution of the morphological characteristics of the cloud shield during the life cycle of the MCS. It consists of a growth–decay linear model of the cloud shield and is based on three parameters: the time of maximum extent, the maximum extent, and the duration of the MCS. It is shown that the time of maximum is frequently close to the middle of the life cycle and that the correlation between maximum extent and duration is strong all over the tropics. This suggests that 1 degree of freedom is left to summarize the life cycle of the MCS cloud shield. Such a model fits the observed MCS equally well, independent of the duration, size, location, and propagation characteristics, and its relevance is assessed for a large number of MCSs over three boreal summer periods over the whole tropical belt. The scaling of this simple model exhibits weak (strong) regional variability for the short- (long-) lived systems indicative of the primary importance of the internal dynamics of the systems to the large-scale environment for MCS sustainability.
The seidozerite supergroup of TS-block minerals: nomenclature and classification, with change of the following names: rinkite to rinkite-(Ce), mosandrite to mosandrite-(Ce), hainite to hainite-(Y) and innelite-1T to innelite-1A
Authors: Sokolova E. , Cámara F. 
Published: February 2017

AbstractHere we report a nomenclature and classification for the seidozerite-supergroup minerals. The TS (Titanium-Silicate) block is the main structural unit in all seidozerite-supergroup structures; it consists of a central O (O = Octahedral) sheet and two adjacent H (H = Heteropolyhedral) sheets where Si2O7groups occur in the H sheets. The TS block is characterized by a planar minimal cell based on translation vectors, t1and t2, the lengths of these vectors are t1 ≈ 5.5 and t2 ≈ 7 Å, and t1 ^ t2 is close to 90°. The forty-five minerals of the sedozerite supergroup are divided into four groups based on the content of Ti and topology and stereochemistry of the TS block: in rinkite, bafertisite, lamprophyllite and murmanite groups, Ti (+ Nb + Zr + Fe3++Mg + Mn) = 1, 2, 3 and 4 apfu (atoms per formula unit), respectively. All TS-block structures consist either solely of TS blocks or of two types of block: the TS block and an I (Intermediate) block that comprises atoms between two TS blocks. Usually, the I block consists of alkali and alkaline-earth cations, H2O groups and oxyanions (PO4)3-, (SO4)2-and (CO3)2-.The general formula of the TS block is as follows AP2BP2MH2MO4(Si2O7)2X4+n, where MH2and MO4= cations of the H and O sheets; MH = Ti, Nb, Zr, Y, Mn, Ca + REE, Ca;MO = Ti, Zr, Nb, Fe3+, Fe2+, Mg, Mn, Zn, Ca, Na; AP and BP = cations at the peripheral (P) sites = Na, Ca + REE, Ca, Zn, Ba, Sr, K; X = anions = O, OH, F, H2O; XO4+n=XO4 +XPn, n = 0, 1, 1.5, 2, 4; XP= XPMand XPA= apical anions of MH and AP cations at the periphery of the TS block.
Circumstantiation: taking a broader look at circumstantial meanings
Authors: Dreyfus Shoshana , Bennett Isabelle 
Published: February 2017

AbstractThis paper argues for a view of circumstantial meaning as a region of ideational meaning that is instantiated across a range of lexicogrammatical structures: from the rank of the clausal constituent of circumstance in both directions: up to clause rank and down to below or within constituent rank (eg as Qualifier). This paper brings together and extends the work of Halliday & Matthiessen (An Introduction to Functional Grammar, 2004) on expansion and circumstantiation, and the work of Martin (English Text: System and Structure, 1992) within the discourse semantic system of ideation. Each type of circumstantial meaning is defined structurally, that is, according to rank, and semantically, according to type. Analysis of circumstantial meanings is conducted on a small corpus of four introductions to journal articles in order to demonstrate the use of viewing circumstantial meaning in this way.
Drug Concentration Errors Related to Sampling from Silastic Catheters
Authors: Quebbeman E. J. , Ausman R. K. , Hamid Ahmed A. R. , Caballero G. , Hoffman N. E. 
Published: February 2017

To the Editor: Constant infusion of some antitumor agents appears to improve their efficacy and/or diminish adverse effects associated with their administration. Silastic catheters placed for long-term central access facilitate this type of therapy. Also, they provide a means to obtain blood with minimal trauma for the patient. During treatment it is sometimes useful to withdraw samples for assay of drug blood levels. When doing so, we became concerned about unusually high 5-fluorouracil (5-FU) values in several patients, causing us to measure drug concentration in samples taken simultaneously from the catheter and a peripheral vein. Catheter samples showed seven to 80 times greater concentration of 5-FU. In one individual who had been off infusion for three days, a small 5-FU concentration persisted in the catheter sample whereas the peripheral vein value was zero as expected. Subsequently, we performed an in vitro study. A Broviac catheter (volume, 0.6 mL) was perfused for five days at 2.0 mL per hour with a solution containing 500 mg 5-FU made up to 60 mL with 0.9% saline. The catheter then was flushed with 30-mL water to remove all fluid containing 5-FU. Ensuing sampling and flushing was done in accordance with Table 1. The last milliliter of flush solution was analyzed in each instance by high-pressure liquid chromatography technology. Since all of the 5-FU infusion solution had been removed, the presence of drug in the water wash indicates that 5-FU was passing into the catheter lumen from the silastic wall. We believe it is important to recognize that other drugs may act in the same way. The use of silastic catheters for both infusion and sampling may lead to an overestimation of drug concentration even though sufficient blood is withdrawn before taking the definitive sample. Please see the PDF for Table.
Only By Products From Many Adjuvant Breast Cancer Studies
Authors: Sauter Christian 
Published: February 2017

To the Editor: The paper by Lippman et al prompts me to send you the following letter that might induce chairpersons of cooperative studies to reflect on the possibility that they may lose years of study time due to inadequate study designs. The report of Lippman et al shows a typical adjuvant breast cancer study where, on the grounds of the study design, only by-products can be expected as results. Surgery-only control subjects were omitted from the study design based on the hypothetical but until today never-proven efficacy of doxorubicincyclophosphamide combination chemotherapy in the adjuvant situation. The main aim of any adjuvant study, if treatment is better than nothing, can not be answered by such a study design. Thus, secondary problems such as the tolerance of cytotoxic drugs after irradiation are studied. In another recently published study, by 1974 surgery-only control subjects were already omitted in an adjuvant cyclophosphamide, methotrexate, 5-fluorouracil (CMF) trial. The three treatment arms (CMF, CMF plus tamoxifen, and CMF plus tamoxifen plus BCG) showed no difference in time to relapse. To extract at least some useful information the prognostic value of progesterone receptors were analyzed. However, the hundreds of CMF cycles were unnecessary for this information. The similarly designed 1976 Swiss study (chlorambucil, methotrexate, and fluorouracil [LMF] for six months v LMF for 24 months) will only demonstrate the known fact of the oncogenicity of chlorambucil. The lessons from such insufficient study designs unfortunately have not been learned in the eighties: The Ludwig Institute V trial on perioperative and adjuvant treatment lacks adequate surgery-only groups for an important prognostic subset (node-positive postmenopausal patients). For this subset the recent publication of the side effects will probably be the only useful information; however, this type of result never justifies the chemotherapy-induced suffering of these women. The new Swiss trial implemented in 1982 that compares CMF v LMF without surgery-only control subjects in one to three node-positive patients is an example of unnecessary chemotherapy (CMF in node-positive postmenopausal women.) From all the studies without adequate control subjects, the best results we can expect are the type of results presented by Lippman et al. With respect to advances in therapeutic decision making, the years spent on these studies are lost.