bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-temporal relational evaluation of the Beijing water crisis and planning implementation from 1949 to 2013
Authors: Fu Wei , Yu Kongjian , Li Dihua 
Published: January 2018

Abstract
Due to a lack of evaluation of the implementation of water planning policies, based on long-term spatio-temporal analysis, this research uses Beijing as an empirical case study to bridge this gap. We analyze the spatio-temporal evolution of water problems and water planning implementations. Content analysis, cluster analysis, and spatial interpolation analysis are used to illustrate the spatio-temporal evolution of water planning implementation. In addition, a grey relational model is developed to determine the impact of the most relevant implementation objects on each water issue. The results indicate that the Beijing water crisis evolves from the center outwards in a planar expansion. However, the water plan implementation shows linear and point characteristics. The majority of implementation categories consist of single-function infrastructure. The implemented categories ‘which show a significant implementation peak’ influence more than one water issue. The categories ‘that were implemented at a steady rate’ have a high relational grade with both surface and underground water shortage problems. Different implementation types from different planning categories may have simultaneous effects on one kind of water problem. Thus, improving water governance is the key to water security in Beijing. This study may serve as a reference for future water planning in other cities.
Sulphur-containing Amino Acids: Protective Role Against Free Radicals and Heavy Metals
Authors: Colovic Mirjana B. , Vasic Vesna M. , Djuric Dragan M. , Krstic Danijela Z. 
Published: January 2018

Background:
Sulphur is an abundant element in biological systems, which plays an
important role in processes essential for life as a constituent of proteins, vitamins and other crucial
biomolecules. The major source of sulphur for humans is plants being able to use inorganic
sulphur in the purpose of sulphur-containing amino acids synthesis. Sulphur-containing amino
acids include methionine, cysteine, homocysteine, and taurine. Methionine and cysteine are classified
as proteinogenic, canonic amino acids incorporated in protein structure. Sulphur amino acids
are involved in the synthesis of intracellular antioxidants such as glutathione and N-acetyl
cysteine. Moreover, naturally occurring sulphur-containing ligands are effective and safe detoxifying
agents, often used in order to prevent toxic metal ions effects and their accumulation in
human body.

Methods:
Literature search for peer-reviewed articles was performed using PubMed and Scopus
databases, and utilizing appropriate keywords.

Results:
This review is focused on sulphur-containing amino acids – methionine, cysteine,
taurine, and their derivatives – glutathione and N-acetylcysteine, and their defense effects as antioxidant
agents against free radicals. Additionally, the protective effects of sulphur-containing
ligands against the toxic effects of heavy and transition metal ions, and their reactivation role towards
the enzyme inhibition are described.

Conclusion:
Sulphur-containing amino acids represent a powerful part of cell antioxidant system.
Thus, they are essential in the maintenance of normal cellular functions and health. In addition
to their worthy antioxidant action, sulphur-containing amino acids may offer a chelating site
for heavy metals. Accordingly, they may be supplemented during chelating therapy, providing
beneficial effects in eliminating toxic metals.
Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids
Authors: Tappia Paramjit S. , Adameova Adriana , Dhalla Naranjan S. 
Published: January 2018

Background:
Patients with diabetes mellitus have an increased risk of mortality
due to cardiovascular complications. Supplementation with specific sulphur-containing
amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes
and associated cardiovascular complications.

Observations:
It is well-known that oxidative stress plays an important role in the pathogenesis
of diabetes-induced cardiovascular disease, which is invariably associated with
abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome.
Cysteine and taurine are among the most common sulphur-containing amino acids
and their cellular levels decline during diabetes that may contribute to the development of
the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular
and subcellular functions in the heart, they also exhibit antioxidant properties and thus
may exert beneficial effects in different pathophysiological conditions.

Conclusion:
It is concluded that reduction of oxidative stress by cysteine and taurine may
serve as an important mechanism for the attenuation of diabetes-induced subcellular and
functional abnormalities in the heart.
Polyphenols: Potential Use in the Prevention and Treatment of Cardiovascular Diseases
Authors: Giglio Rosaria Vincenza , Patti Angelo Maria , Cicero Arrigo F.G. , Lippi Giuseppe , Rizzo Manfredi , Toth Peter P. , Banach Maciej 
Published: January 2018

Background:
Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals,
vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in
the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses.
Their effects on human health depend on the amount consumed and on their bioavailability. Many studies
have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure,
improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density
lipoprotein oxidation, and reducing inflammatory responses.

Methods:
This review is focused on some groups of polyphenols and their effects on several cardiovascular risk
factors such as hypertension, oxidative stress, atherogenesis, endothelial dysfunction, carotid artery intima-media
thickness, diabetes and lipid disorders.

Results:
It is proved that these compounds have many cardio protective functions: they alter hepatic cholesterol
absorption, triglyceride biosynthesis and lipoprotein secretion, the processing of lipoproteins in plasma, and inflammation.
In some cases, human long-term studies did not show conclusive results because they lacked in appropriate
controls and in an undefined polyphenol dosing regimen.

Conclusion:
Rigorous evidence is necessary to demonstrate whether or not polyphenols beneficially impact CVD
prevention and treatment.
Melatonin Differentially Modulates NF-кB Expression in Breast and Liver Cancer Cells
Authors: Colombo Jucimara , Jardim-Perassi Bruna V. , Ferreira João P.S. , Braga Cristine Z. , Sonehara Nathália M. , Júnior Rubens P. , Moschetta Marina G. , Girol Ana P. , Zuccari Debora A.P.C. 
Published: January 2018

Background:
NF-kB (nuclear factor kappa B) is a transcription factor composed of two subunits, p50
and p65, which plays a key role in the inflammatory process. Melatonin has oncostatic, antiangiogenic and
antimetastatic properties, and some recent studies have indicated an inhibitory effect of melatonin on NF-kB in
some types of cancer. This work aims to investigate the effects of melatonin treatment on the expression of NFkB
in breast and liver cancer models.

Method:
The breast cancer xenographic model was performed using female Balb/c nude athymic mice injected
with MDA-MB-231 cells. The animals were treated with 40 mg/Kg of melatonin for 21 days. Volume of the
tumors was measured with a digital caliper. Hepatocarcinoma model was developed by using the HepG2 cells in
vitro, treated with 1 mM melatonin for 24 h. The expression of NF-kB protein was verified by immunohistochemistry
and immunocytochemistry and quantified by optical densitometry, in vivo study and in vitro study,
respectively. NF-kB gene expression was performed by quantitative RT-PCR.

Results:
The breast cancer xenografts nude mice treated with melatonin showed reduced tumor size (P=0.0022).
There was a decrease in NF-kB protein staining (P=0.0027) and gene expression (P=0.0185) in mice treated
with melatonin. The opposite results were observed for the hepatocarcinoma model. HepG2 cells treated with
melatonin showed an increase in the NF-kB immunostaining when compared to control cells (P=0.0042).

Conclusion:
Our results indicated that the treatment with melatonin was able to decrease both gene and protein
expressions of NF-kB in breast cancer cells and, conversely, increase the transcription factor protein expression
in hepatocarcinoma cells. These data highlighted a double role in the expression of NF-kB, depending on the
cell type. Further studies are needed to better elucidate the action of melatonin in NF-kB, since this transcription
factor acts on different signaling pathways that are fundamental for carcinogenesis.
Da pronúncia das políticas à efetivação do direito: a condição humana em debate
Authors: Lima Paulo Gomes 
Published: January 2018

O debate aberto no volume 4, número 1 de 2018 da Laplage em Laplage em Revista organizado pelos Professores doutores Viviane Melo de Mendonça e Márcio Antônio Gatti, ambos do Departamento de Ciências Humanas e Educação do campus Sorocaba da UFSCar, é atual e repleto de pontuações concernentes à condição humana que se autoproduz e produz suas convenções, a ideia de valor e direitos validados ou não em políticas públicas. O tema trabalhado nesse Dossiê por autores de distintas instituições do Brasil e “overseas” não trata somente das políticas já existentes, de sua operância ou o contrário, não trata somente da necessidade do anúncio e consolidação de novas políticas ou a readequação das já existentes quanto ao(s) direito(s) das pessoas serem respeitadas em sua dignidade, mas e sobretudo de colocar em evidência as vozes e ressignificações de seres humanos historicamente ignorados ou rechaçados no contexto de sua diversidade e singularidade, sem que se tornem menos cidadãos como os demais.
Firm's default ? new methodological approach and preliminary evidence from Poland
Authors: Berent Tomasz , Bławat Bogusław , Dietl Marek , Krzyk Przemysław , Rejman Radosław 
Published: January 2018

Research background: Bankruptcy literature is populated with scores of (econometric) models ranging from Altman?s Z-score, Ohlson?s O-score, Zmijewski?s probit model to k-nearest neighbors, classification trees, support vector machines, mathematical programming, evolutionary algorithms or neural networks, all designed to predict financial distress with highest precision. We believe corporate default is also an important research topic to be identified with the prediction accuracy only. Despite the wealth of modelling effort, a unified theory of default is yet to be proposed.
Purpose of the article: Due to the disagreement both on the definition and hence the timing of default, as well as on the measurement of prediction accuracy, the comparison (of predictive power) of various models can be seriously misleading. The purpose of the article is to argue for the shift in research focus from maximizing accuracy to the analysis of the information capacity of predictors. By doing this, we may yet come closer to understanding default itself.
Methods: We critically appraise the bankruptcy research literature for its methodological variety and empirical findings. Default definitions, sampling procedures, in and out-of-sample testing and accuracy measurement are all scrutinized. In an empirical part, we use a double stochastic Poisson process with multi-period prediction horizon and a comprehensive database of some 15,000 Polish non-listed companies to illustrate the merits of our new approach to default modelling.
Findings & Value added: In the theoretical part, we call for the construction of a single unified default forecasting platform estimated for the largest dataset of firms possible to allow testing the utility of various sources of micro, mezzo, and macro information. Our preliminary empirical evidence is encouraging. The accuracy ratio amounts to 0.92 for t = 0 and drops to 0.81 two years ahead of default. We point to the pivotal role played by the information on firm?s liquidity (alternatively in profitability) and ? in contrast to Altman?s tradition ? hardly any contribution to predictive power of other financial ratios. Macro data is shown to be critical. It adds, on average, more than 10 p.p. to accuracy ratio. In the future, we hope to integrate listed and non-listed firms data into one model, ideally at higher frequency than annual, and include the information on firm's competitiveness position.
ADIPONECTIN SERUM LEVEL DIFFERENCE IN WOMEN WITH ENDOMETRIOTIC AND NON-ENDOMETRIOTIC CYSTS
Authors: Anwar Ruswana , Fahdiansyah Fahdiansyah 
Published: January 2018

Endometriosis is an estrogen-dependent disease. Low levels of adiponectin resulted in an increased free estrogen levels and the inability to inhibit angiogenesis and the inflammatory process resulting in the development of increasingly severe endometriosis.This study is aimed to determine the differences in serum adiponectin levels in patient with nonendometriotic cyst with endometriosis cyst and its relationship with endometriosis stages. This is an analytical comparative study with cross-sectional method in group of women with endometriotic cyst (n=25) and women with non-endometriotic cysts (n=25), performed either laparoscopic or laparotomy surgery. The serum levels of adiponectin in both groups then compared with statistical analysis.The results showed there were no significant differences (p>0,05) on the characteristics of the study subjects in terms of age (p=0.994) and BMI (p=0.27). Significant differences of adiponectin levels were found between endometriotic patient group (mean=3.91) and nonendometriotic patients group (mean=8.59). There were no significant differences of adiponectin level in stages III endometriosis (mean = 4.24) and stage IV endometriosis (mean = 3.54).It is concluded that serum adiponectin levels in patients with endometriosis is lower than patient with non-endometriotic cyst. There is no relationship between adiponectin levels with endometriosis stage. Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage
Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney
Authors: Hidayat Meilinah , Prahastuti Sijani , Chikita Vibiola , Safitri Dewi , Rahmawati Siti F. , Soemardji Andreanus A. 
Published: January 2018

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed. This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretation’s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJB have a good effect on kidney function, did not lead to changes in organ weight and at low doses did not cause disturbance of renal histopathology. Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidney’s weight, kidney’s histopathology
Hubungan Dukungan Suami dengan Kecemasan Wanita yang Mengalami Menopause di Dusun Karang Jati Sleman Yogyakarta
Authors: Hermawati Ika , Winarti Sri Arini , Ratnasari Dewi 
Published: January 2018

Background: The husband's support was the most improved external factors in helping the wife to go through the menopause without excess anxiety.Support on women in the past through menoapuse in need of surrounding people especially the husband as life partner. Data of menopausal women a village Sleman Yogyakarta is 150 people. After a Screening at the time of the preliminary study in the village of Sleman Yogyakarta there are 60 women who are anxious.
Aim: To know the relation between husband’s support with anxiety woman who had menopause in Karangjati Sleman, Yogyakarta
Methods: This study used a survey of analytical research methods with cross sectional approach. The subject of this research is on 60 menopausal women. Data retrieval using guided questionnaire that have been tested by there searchers. Data analysis performed using Spearman Ranktest.
Result: The husband's support in menopausal women in the category of poor numbered 25 persons (41.7%). The level of anxiety of menopausal women in the category of Weight numbered 39 persons (65%). Based on the results of statistical values P value = 0,014 (p<0.05), there is a relation between husband’ssupport with anxiety woman who had menopause in KarangJati Sleman,Yogyakarta
Conclusion: There is a relation between husband’s support with anxiety woman who had menopause in Karang Jati, Sleman,Yogyakarta
Behavior Change After HIV/AIDS Diagnosis of Female Sexuality in The Yogyakarta City
Authors: Sari Dwi Agustiana , Subronto Yanri Wijayanti , Lismidianti Wiwin 
Published: January 2018

Background: Anxiety, panic, inability to accept the conditions and low knowledge about good sexual behaviour can worsen HIV status.
Purpose: assess changes in sexual behavior before, the time of diagnosis, and current and causes.
Methode: Qualitative research phenomenological, semi-structured interviews with in dept interviews in 6 Participants women of reproductive age, diagnosed with HIV between 1-2 years before study, has been or ever married. Analysis using Collaizy.
Result: before diagnosis frequency: rarely and still routine, sexual behavior: oral, anal and masturbated to couples, sexual desire did not a decline. Causal factor that changes sexual behavior is a condition of pain, impaired self-image, increasing socio-economic burden, and change partners.
Dicussion: Hankins (1997) the majority of women after hear of HIV positive status will experience a significant disruption to the desire, arousal and orgasm function, is due to physiological and psychological factors. Recurrent pain during sexual intercourse can lead to avoidance. Psychosocial factors (stress, financial crisis, depression, anxiety) inhibit the production of liquid lubrication. Working full- time cause fatigue and decrease sexual desire for women with HIV.
Hubungan Tingkat Pengetahuan Remaja Tentang Kesehatan Reproduksi dengann Perilaku Seks Bebas pada Siswa Kelas XI SMA Negeri 6 Surakarta
Authors: Prabandari Febry Heldayasari , Rahayu Tri Budi 
Published: January 2018

Latar Belakang: Angka aborsi di Indonesia diperkirakan mencapai 2,3 juta per tahun, sekitar 750.000 diantaranya dilakukan oleh remaja. Dari hasil penelitian pada remaja pada sepuluh SMA di Surakarta tahun 2005 ditemukan bahwa 30% laki-laki yang berpacaran telah melakukan hubungan seksual, sedangkan untuk perempuan sebanyak 5 %. Kurangnya pemahaman tentang perilaku seksual pada masa remaja adalah salah satu penyebabnya.
Tujuan Penelitian: Penelitian bertujuan untuk mengetahui hubungan pengetahuan tentang kesehatan reproduksi dengan perilaku seks bebas di SMA Negeri 6 Surakarta.
Metode Penelitian: Penelitian menggunakan desain observational analitik dengan rancangan cross sectional. Teknik sampling yang digunakan simple random sampling dengan jumlah sampel 177 siswa. Analisa data menggunakan uji statistik korelasi Kendall Tau (τ).
Hasil Penelitian: 125 siswa (70.6%) memiliki pengetahuan yang baik tentang kesehatan reproduksi dan 52 siswa (75,0%) memiliki perilaku yang baik dalam pergaulan seks bebas. Dari hasil analisa data dengan Kendall Tau diperoleh zhitung (9,96) > ztabel (1,96). Simpulan: ada hubungan yang signifikan antara pengetahuan remaja tentang kesehatan reproduksi dengan perilaku seks bebas.
Risk Factors of Hypercholesterolemia on Obese Pre-elderly Population in Rejosari Sub-village Gunung Kidul Yogyakarta
Authors: Arisandi Desto , Apriliasari Yesi , Widada Subrata Tri 
Published: January 2018

Background: Obesity is one of the most epidemiological burden which is being a dangerous threat for global health. It also contributes for leading cause of hypercholesterolemia. Prevalence of stroke, diabetes mellitus, coronary heart disease, and hypertension in Indonesia has reached out 23.7% in 2007. Rejosari sub-village, Kemadang village, Tanjungsari sub-district locate in coastal area which is fisher taking mostly part of the citizen's occupation. Hence they have tendency to intake sea products such as shrimps, squids, crabs, anchovies, and bivalves that contain amino acid required to growth and cell recovery nevertheless it also has much cholesterol contained which cause of total cholesterol level rising. The aims of this study to determine risk factors of hypercholesterolemia on obese pre-eldery population in Rejosari sub-village, Kemadang village, Tanjungsari sub-district, Gunung Kidul district, Yogyakarta.
Method: This was an analytic observational study with cross sectional that conducted on February 2015 on obese pre-eldery population in Rejosari sub-village, Kemadang village, Tanjungsari sub-district, Gunung Kidul district, Yogyakarta. Data collected such age, sex, blood pressure, seafood intake frequencies, and total cholesterol. Data were analyzed by STATA version 12 software for windows with spearman correlation statistical test.
Result: This study findings that 30 pre-elderly people came as respondents. Data performed the average value of age was 49 years old, systolic blood pressure was 142 mmHg, diastolic blood pressure was 87 mmHg, seafood intake frequencies was 3 times per week, and total cholesterol level was 241 mg/dl. Spearman correlation shown age (p value=0.0477), systolic blood pressure (p value=0.0012), diasolic blood pressure (p value= 0.0435) and seafood intake frequencies (p value= 0.0018) have stattistical correlation with hypercholesterolemia.
Conclusion:Age, systolic blood pressure, diastolic blood pressure, and seafood intake frequencies are correlated with total cholesterol raising within blood.