bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-dimensional honeycomb network through sequence-controlled self-assembly of oligopeptides
Authors: Abb Sabine , Harnau Ludger , Gutzler Rico , Rauschenbach Stephan , Kern Klaus 
Published: January 2016

AbstractThe sequence of a peptide programs its self-assembly and hence the expression of specific properties through non-covalent interactions. A large variety of peptide nanostructures has been designed employing different aspects of these non-covalent interactions, such as dispersive interactions, hydrogen bonding or ionic interactions. Here we demonstrate the sequence-controlled fabrication of molecular nanostructures using peptides as bio-organic building blocks for two-dimensional (2D) self-assembly. Scanning tunnelling microscopy reveals changes from compact or linear assemblies (angiotensin I) to long-range ordered, chiral honeycomb networks (angiotensin II) as a result of removal of steric hindrance by sequence modification. Guided by our observations, molecular dynamic simulations yield atomistic models for the elucidation of interpeptide-binding motifs. This new approach to 2D self-assembly on surfaces grants insight at the atomic level that will enable the use of oligo- and polypeptides as large, multi-functional bio-organic building blocks, and opens a new route towards rationally designed, bio-inspired surfaces.
Manipulation of charge transfer and transport in plasmonic-ferroelectric hybrids for photoelectrochemical applications
Authors: Wang Zhijie , Cao Dawei , Wen Liaoyong , Xu Rui , Obergfell Manuel , Mi Yan , Zhan Zhibing , Nasori Nasori , Demsar Jure , Lei Yong 
Published: January 2016

AbstractUtilizing plasmonic nanostructures for efficient and flexible conversion of solar energy into electricity or fuel presents a new paradigm in photovoltaics and photoelectrochemistry research. In a conventional photoelectrochemical cell, consisting of a plasmonic structure in contact with a semiconductor, the type of photoelectrochemical reaction is determined by the band bending at the semiconductor/electrolyte interface. The nature of the reaction is thus hard to tune. Here instead of using a semiconductor, we employed a ferroelectric material, Pb(Zr,Ti)O3 (PZT). By depositing gold nanoparticle arrays and PZT films on ITO substrates, and studying the photocurrent as well as the femtosecond transient absorbance in different configurations, we demonstrate an effective charge transfer between the nanoparticle array and PZT. Most importantly, we show that the photocurrent can be tuned by nearly an order of magnitude when changing the ferroelectric polarization in PZT, demonstrating a versatile and tunable system for energy harvesting.
Large Scale Synthesis of NiCo Layered Double Hydroxides for Superior Asymmetric Electrochemical Capacitor
Authors: Li Ruchun , Hu Zhaoxia , Shao Xiaofeng , Cheng Pengpeng , Li Shoushou , Yu Wendan , Lin Worong , Yuan Dingsheng 
Published: January 2016

AbstractWe report a new environmentally-friendly synthetic strategy for large-scale preparation of 16 nm-ultrathin NiCo based layered double hydroxides (LDH). The Ni50Co50-LDH electrode exhibited excellent specific capacitance of 1537 F g−1 at 0.5 A g−1 and 1181 F g−1 even at current density as high as 10 A g−1, which 50% cobalt doped enhances the electrical conductivity and porous and ultrathin structure is helpful with electrolyte diffusion to improve the material utilization. An asymmetric ultracapacitor was assembled with the N-doped graphitic ordered mesoporous carbon as negative electrode and the NiCo LDH as positive electrode. The device achieves a high energy density of 33.7 Wh kg−1 (at power density of 551 W kg−1) with a 1.5 V operating voltage.
Non-periodic oscillatory deformation of an actomyosin microdroplet encapsulated within a lipid interface
Authors: Nishigami Yukinori , Ito Hiroaki , Sonobe Seiji , Ichikawa Masatoshi 
Published: January 2016

AbstractActive force generation in living organisms, which is mainly involved in actin cytoskeleton and myosin molecular motors, plays a crucial role in various biological processes. Although the contractile properties of actomyosin have been extensively investigated, their dynamic contribution to a deformable membrane remains unclear because of the cellular complexities and the difficulties associated with in vitro reconstitution. Here, by overcoming these experimental difficulties, we demonstrate the dynamic deformation of a reconstituted lipid interface coupled with self-organized structure of contractile actomyosin. Therein, the lipid interface repeatedly oscillates without any remarkable periods. The oscillatory deformation of the interface is caused by the aster-like three-dimensional hierarchical structure of actomyosin inside the droplet, which is revealed that the oscillation occurs stochastically as a Poisson process.
Assembling carbon quantum dots to a layered carbon for high-density supercapacitor electrodes
Authors: Chen Guanxiong , Wu Shuilin , Hui Liwei , Zhao Yuan , Ye Jianglin , Tan Ziqi , Zeng Wencong , Tao Zhuchen , Yang Lihua , Zhu Yanwu 
Published: January 2016

AbstractIt is found that carbon quantum dots (CQDs) self-assemble to a layer structure at ice crystals-water interface with freeze- drying. Such layers interconnect with each other, forming a free-standing CQD assembly, which has an interlayer distance of about 0.366 nm, due to the existence of curved carbon rings other than hexagons in the assembly. CQDs are fabricated by rupturing C60 by KOH activation with a production yield of ~15 wt.%. The CQDs obtained have an average height of 1.14 nm and an average lateral size of 7.48 nm and are highly soluble in water. By packaging annealed CQD assembly to high density (1.23 g cm−3) electrodes in supercapacitors, a high volumetric capacitance of 157.4 F cm−3 and a high areal capacitance of 0.66 F cm−2 (normalized to the loading area of electrodes) are demonstrated in 6 M KOH aqueous electrolyte with a good rate capability.
Quinary wurtzite Zn-Ga-Ge-N-O solid solutions and their photocatalytic properties under visible light irradiation
Authors: Xie Yinghao , Wu Fangfang , Sun Xiaoqin , Chen Hongmei , Lv Meilin , Ni Shuang , Liu Gang , Xu Xiaoxiang 
Published: January 2016

AbstractWurtzite solid solutions between GaN and ZnO highlight an intriguing paradigm for water splitting into hydrogen and oxygen using solar energy. However, large composition discrepancy often occurs inside the compound owing to the volatile nature of Zn, thereby prescribing rigorous terms on synthetic conditions. Here we demonstrate the merits of constituting quinary Zn-Ga-Ge-N-O solid solutions by introducing Ge into the wurtzite framework. The presence of Ge not only mitigates the vaporization of Zn but also strongly promotes particle crystallization. Synthetic details for these quinary compounds were systematically explored and their photocatalytic properties were thoroughly investigated. Proper starting molar ratios of Zn/Ga/Ge are of primary importance for single phase formation, high particle crystallinity and good photocatalytic performance. Efficient photocatalytic hydrogen and oxygen production from water were achieved for these quinary solid solutions which is strongly correlated with Ge content in the structure. Apparent quantum efficiency for optimized sample approaches 1.01% for hydrogen production and 1.14% for oxygen production. Theoretical calculation reveals the critical role of Zn for the band gap reduction in these solid solutions and their superior photocatalytic acitivity can be understood by the preservation of Zn in the structure as well as a good crystallinity after introducing Ge.
A Novel Naturally Occurring Class I 5-Enolpyruvylshikimate-3-Phosphate Synthase from Janibacter sp. Confers High Glyphosate Tolerance to Rice
Authors: Yi Shu-yuan , Cui Ying , Zhao Yan , Liu Zi-duo , Lin Yong-jun , Zhou Fei 
Published: January 2016

AbstractAs glyphosate is a broad spectrum herbicide extensively used in agriculture worldwide, identification of new aroA genes with high level of glyphosate tolerance is essential for the development and breeding of transgenic glyphosate-tolerant crops. In this study, an aroA gene was cloned from a Janibacter sp. strain isolated from marine sediment (designated as aroAJ. sp). The purified aroAJ. sp enzyme has a Km value of 30 μM for PEP and 83 μM for S3P and a significantly higher Ki value for glyphosate (373 μM) than aroAE. coli. AroAJ. sp is characterized as a novel and naturally occurring class I aroA enzyme with glyphosate tolerance. Furthermore, we show that aroAJ. sp can be used as an effective selectable marker in both japonica and indica rice cultivar. Transgenic rice lines were tested by herbicide bioassay and it was confirmed that they could tolerate up to 3360 g/ha glyphosate, a dosage four-fold that of the recommended agricultural application level. To our knowledge, it is the first report of a naturally occurring novel class I aroA gene which can be efficiently utilized to study and develop transgenic glyphosate-tolerant crops and can facilitate a more economical and simplified weed control system.
Spike processing with a graphene excitable laser
Authors: Shastri Bhavin J. , Nahmias Mitchell A. , Tait Alexander N. , Rodriguez Alejandro W. , Wu Ben , Prucnal Paul R. 
Published: January 2016

AbstractNovel materials and devices in photonics have the potential to revolutionize optical information processing, beyond conventional binary-logic approaches. Laser systems offer a rich repertoire of useful dynamical behaviors, including the excitable dynamics also found in the time-resolved “spiking” of neurons. Spiking reconciles the expressiveness and efficiency of analog processing with the robustness and scalability of digital processing. We demonstrate a unified platform for spike processing with a graphene-coupled laser system. We show that this platform can simultaneously exhibit logic-level restoration, cascadability and input-output isolation—fundamental challenges in optical information processing. We also implement low-level spike-processing tasks that are critical for higher level processing: temporal pattern detection and stable recurrent memory. We study these properties in the context of a fiber laser system and also propose and simulate an analogous integrated device. The addition of graphene leads to a number of advantages which stem from its unique properties, including high absorption and fast carrier relaxation. These could lead to significant speed and efficiency improvements in unconventional laser processing devices and ongoing research on graphene microfabrication promises compatibility with integrated laser platforms.
Strongly-motivated positive affects induce faster responses to local than global information of visual stimuli: an approach using large-size Navon letters
Authors: Noguchi Yasuki , Tomoike Kouta 
Published: January 2016

AbstractRecent studies argue that strongly-motivated positive emotions (e.g. desire) narrow a scope of attention. This argument is mainly based on an observation that, while humans normally respond faster to global than local information of a visual stimulus (global advantage), positive affects eliminated the global advantage by selectively speeding responses to local (but not global) information. In other words, narrowing of attentional scope was indirectly evidenced by the elimination of global advantage (the same speed of processing between global and local information). No study has directly shown that strongly-motivated positive affects induce faster responses to local than global information while excluding a bias for global information (global advantage) in a baseline (emotionally-neutral) condition. In the present study, we addressed this issue by eliminating the global advantage in a baseline (neutral) state. Induction of positive affects under this state resulted in faster responses to local than global information. Our results provided direct evidence that positive affects in high motivational intensity narrow a scope of attention.
Highly hydrophilic poly(vinylidene fluoride)/meso-titania hybrid mesoporous membrane for photocatalytic membrane reactor in water
Authors: Wang Meng , Yang Guang , Jin Peng , Tang Hao , Wang Huanhuan , Chen Yong 
Published: January 2016

AbstractThe high hydrophobicity of poly(vinylidene fluoride) (PVDF) membrane remains an obstacle to be applied in some purification processes of water or wastewater. Herein, a highly hydrophilic hybrid mesoporous titania membrane composed of mesoporous anatase titania (meso-TiO2) materials inside the three-dimensional (3D) macropores of PVDF membrane was successfully prepared by using the dual-templated synthesis method combined with solvent extraction and applied as the photocatalytic membrane reactor for the photodegredation of organic dye in water. The structure and the properties of as-prepared hybrid membranes were characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), X-ray diffraction (XRD), nitrogen adsorption–desorption and contact angle measurements. It was found that the hydrophilicity of PVDF membrane can be significantly improved by filling mesoporous TiO2 inside the 3D macropores of PVDF membrane. Moreover, such a PVDF/meso-TiO2 hybrid membrane exhibits promising photocatalytic degradation of dye in water due to the existence of mesoporous anatase TiO2 materials inside PVDF membrane. This study provides a new strategy to simultaneously introduce hydrophilicity and some desirable properties into PVDF and other hydrophobic membranes.
Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL
Authors: Xiang Jin-Feng , Wang Wen-Quan , Liu Liang , Xu Hua-Xiang , Wu Chun-Tao , Yang Jing-Xuan , Qi Zi-Hao , Wang Ya-Qi , Xu Jin , Liu Chen , Long Jiang , Ni Quan-Xing , Li Min , Yu Xian-Jun 
Published: January 2016

AbstractPatients with pancreatic ductal adenocarcinoma (PDAC) and preoperative CA19-9 ≥ 1,000 U/mL that does not decrease postresection have the worst prognosis, but the mechanism is unclear. Here, we elucidated the relationship between this signature and driver-gene mutations and the cavins/caveolin-1 axis. Four major driver-genes (KRAS, TP53, CDKN2A/p16, and SMAD4/DPC4) that are associated with PDAC and five critical molecules (cavin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened by immunohistochemistry in tumor tissue microarrays. Additionally, six pancreatic cancer cell lines and a spleen subcapsular inoculation nude mouse model were also used. Overexpression of mutant p53 was the major mutational event in patients with the CA19-9 signature. Cavin-1 was also overexpressed and mutant p53 correlated directly with high cavin-1 expression in pancreatic cancer cell lines and tumor specimens (P < 0.01). Furthermore, mutant p53R172H upregulated cavin-1 and promoted invasiveness and metastasis of pancreatic cancer cells in vitro and in vivo. Finally, combination of mutant p53 and high cavin-1 density indicated the shortest survival for patients with PDAC after resection (P < 0.001). Mutant p53-driven upregulation of cavin-1 represents the major mechanism of poor outcome for PDAC patients with the CA19-9 signature after resection, indicating that inhibition of cavin-1 may improve the long-term efficacy of pancreatectomy.
Seismology-based early identification of dam-formation landquake events
Authors: Chao Wei-An , Zhao Li , Chen Su-Chin , Wu Yih-Min , Chen Chi-Hsuan , Huang Hsin-Hua 
Published: January 2016

AbstractFlooding resulting from the bursting of dams formed by landquake events such as rock avalanches, landslides and debris flows can lead to serious bank erosion and inundation of populated areas near rivers. Seismic waves can be generated by landquake events which can be described as time-dependent forces (unloading/reloading cycles) acting on the Earth. In this study, we conduct inversions of long-period (LP, period ≥20 s) waveforms for the landquake force histories (LFHs) of ten events, which provide quantitative characterization of the initiation, propagation and termination stages of the slope failures. When the results obtained from LP waveforms are analyzed together with high-frequency (HF, 1–3 Hz) seismic signals, we find a relatively strong late-arriving seismic phase (dubbed Dam-forming phase or D-phase) recorded clearly in the HF waveforms at the closest stations, which potentially marks the time when the collapsed masses sliding into river and perhaps even impacting the topographic barrier on the opposite bank. Consequently, our approach to analyzing the LP and HF waveforms developed in this study has a high potential for identifying five dam-forming landquake events (DFLEs) in near real-time using broadband seismic records, which can provide timely warnings of the impending floods to downstream residents.
LA-ICP-MS imaging in multicellular tumor spheroids – a novel tool in the preclinical development of metal-based anticancer drugs
Authors: Theiner Sarah , Schreiber-Brynzak Ekaterina , Jakupec Michael A , Galanski Mathea S , Koellensperger Gunda , Keppler Bernhard K 
Published: January 2016

Abstract
A novel application of advanced elemental imaging offers cutting edge in vitro assays with more predictive power on the efficacy of anticancer drugs in preclinical development compared to two dimensional cell culture models. We propose LA-ICP-MS analysis of multicellular spheroids, which are increasingly being used as three dimensional (3D) models of tumors, for improving the in vitro evaluation of anticancer metallodrugs. The presented strategy is very well suited for screening drug–tumor penetration, a key issue for drug efficacy. A major advantage of tumor spheroid models is that they enable us to create a tissue-like structure and function. With respect to 2D culture on the one hand and in vivo models on the other, multicellular spheroids thus show intermediate complexity, still allowing high repeatability and adequate through-put for drug research. This strongly argues for the use of spheroids as bridging models in preclinical anticancer drug development. Probing the lateral platinum distribution within these tumor models allows visualizing the penetration depth and targeting of platinum-based complexes. In the present study, we show for the first time that spatially-resolved metal accumulation in tumor spheroids upon treatment with platinum compounds can be appropriately assessed. The optimized LA-ICP-MS setup allowed discerning the platinum localization in different regions of the tumor spheroids upon compound treatment at biologically relevant (low micromolar) concentrations. Predominant platinum accumulation was observed at the periphery as well as in the center of the spheroids. This corresponds to the proliferating outermost layers of cells and the necrotic core, respectively, indicating enhanced platinum sequestration in these regions.
Coalition logic with individual, distributed and common knowledge1
Authors: Ågotnes Thomas , Alechina Natasha 
Published: January 2016

Abstract
Coalition logic is currently one of the most popular logics for multi-agent systems. While logics combining coalitional and epistemic operators have received considerable attention, completeness results for epistemic extensions of coalition logic have so far been missing. In this paper we provide several such results and proofs. We prove completeness for epistemic coalition logic with common knowledge, with distributed knowledge, and with both common and distributed knowledge, respectively. Furthermore, we completely characterise the complexity of the satisfiability problem for each of the three logics. We also study logics with interaction axioms connecting coalitional ability and knowledge.
Etiology of Cellulitis and Clinical Prediction of Streptococcal Disease: A Prospective Study
Authors: Bruun Trond , Oppegaard Oddvar , Kittang Bård R. , Mylvaganam Haima , Langeland Nina , Skrede Steinar 
Published: January 2016

Abstract
Background.  The importance of bacteria other than group A streptococci (GAS) in different clinical presentations of cellulitis is unclear, commonly leading to treatment with broad-spectrum antibiotics. The aim of this study was to describe the etiological and clinical spectrum of cellulitis and identify clinical features predicting streptococcal etiology.
Methods.  We prospectively enrolled 216 patients hospitalized with cellulitis. Clinical details were registered. Bacterial culture was performed from blood, cutaneous or subcutaneous tissue, and/or swabs from skin lesions. Paired serum samples were analyzed for anti-streptolysin O and anti-deoxyribonuclease B antibodies.
Results.  Serology or blood or tissue culture confirmed β-hemolytic streptococcal (BHS) etiology in 72% (146 of 203) of cases. An additional 13% (27 of 203) of cases had probable BHS infection, indicated by penicillin response or BHS cultured from skin swabs. β-hemolytic streptococcal etiology was predominant in all clinical subgroups, including patients without sharply demarcated erythema. β-hemolytic group C or G streptococci (GCS/GGS) were more commonly isolated than GAS (36 vs 22 cases). This predominance was found in the lower extremity infections. Group C or G streptococci in swabs were associated with seropositivity just as often as GAS. Staphylococcus aureus was cultured from swabs as a single pathogen in 24 cases, 14 (64%) of which had confirmed BHS etiology. Individual BHS-associated clinical characteristics increased the likelihood of confirmed BHS disease only slightly; positive likelihood ratios did not exceed 2.1.
Conclusions.  β-hemolytic streptococci were the dominating cause of cellulitis in all clinical subgroups and among cases with S aureus in cutaneous swabs. Group C or G streptococci were more frequently detected than GAS. No single clinical feature substantially increased the probability of confirmed BHS etiology.
Using Computer Vision and Depth Sensing to Measure Healthcare Worker-Patient Contacts and Personal Protective Equipment Adherence Within Hospital Rooms
Authors: Chen Junyang , Cremer James F. , Zarei Kasra , Segre Alberto M. , Polgreen Philip M. 
Published: January 2016

Abstract
Background.  We determined the feasibility of using computer vision and depth sensing to detect healthcare worker (HCW)-patient contacts to estimate both hand hygiene (HH) opportunities and personal protective equipment (PPE) adherence.
Methods.  We used multiple Microsoft Kinects to track the 3-dimensional movement of HCWs and their hands within hospital rooms. We applied computer vision techniques to recognize and determine the position of fiducial markers attached to the patient's bed to determine the location of the HCW's hands with respect to the bed.
To measure our system's ability to detect HCW-patient contacts, we counted each time a HCW's hands entered a virtual rectangular box aligned with a patient bed. To measure PPE adherence, we identified the hands, torso, and face of each HCW on room entry, determined the color of each body area, and compared it with the color of gloves, gowns, and face masks. We independently examined a ground truth video recording and compared it with our system's results.
Results.  Overall, for touch detection, the sensitivity was 99.7%, with a positive predictive value of 98.7%. For gowned entrances, sensitivity was 100.0% and specificity was 98.15%. For masked entrances, sensitivity was 100.0% and specificity was 98.75%; for gloved entrances, the sensitivity was 86.21% and specificity was 98.28%.
Conclusions.  Using computer vision and depth sensing, we can estimate potential HH opportunities at the bedside and also estimate adherence to PPE. Our fine-grained estimates of how and how often HCWs interact directly with patients can inform a wide range of patient-safety research.