bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition‐Metal Free Amination and Hydrodefluorination of Aryl Fluorides Promoted by Solvated Electrons
Authors: Williams Anietie W. , Gilmore Kerry M. 
Published: September 2024

AbstractCross‐coupling reactions for constructing C−N bonds represent a pivotal advancement in chemical science. Traditional methodologies, including nucleophilic aromatic substitution (SNAr) and transition metal‐catalyzed cross‐couplings, have limitations concerning aryl scope, reliance on toxic and costly transition‐metal catalysts, and issues related to atom economy and waste generation from ligands and additives. In this work, we introduce a novel method for aminating neutral, electron‐rich, and electron‐deficient aryl halides, eliminating the need for transition metals. Our approach involves the activation of aryl halides using solvated electrons generated from granulated lithium and sonication. This serves as a sustainable source of reducing power, facilitating the efficient formation of C−N bonds under near ambient conditions. Competitive selectivity studies between halide and ester functionalities were explored. Reaction scope and conducted mechanistic studies which supported the proposed radical‐nucleophilic substitution (SRN1) mechanism for the reaction. Notably, the developed reaction has a highly competitive reductive dehalogenation pathway during the C−N coupling reaction, and this mechanistic divergency was thoroughly explored. This work not only broadens the scope of C−N coupling reactions which typically employs aryl bromides and iodides and rarely aryl fluorides which is also equally abundant, but also introduces a new way to do C−N coupling reactions using solvated electrons.
Integrated Identification and Immunotherapy Response Analysis of the Prognostic Signature Associated With m6A, Cuproptosis‐Related, Ferroptosis‐Related lncRNA in Endometrial Cancer
Authors: Qian Yongkang , Chen Hualing , Miao Pengcheng , Ma Rongji , Lu Beier , Hu Chenhua , Fan Ru , Xu Biyun , Chen Bingwei 
Published: September 2024

ABSTRACTBackgroundEndometrial cancer (EC) stands as the predominant gynecological malignancy impacting the female reproductive system on a global scale. N6‐methyladenosine, cuproptosis‐ and ferroptosis‐related biomarker is beneficial to the prognostic of tumor patients. Nevertheless, the correlation between m6A‐modified lncRNAs and ferroptosis, copper‐induced apoptosis in the initiation and progression of EC remains unexplored in existing literature.AimsIn this study, based on bioinformatics approach, we identified lncRNAs co‐expressing with cuproptosis‐, ferroptosis‐, m6A‐ related lncRNAs from expression data of EC. By constructing the prognosis model in EC, we screened hub lncRNA signatures affecting prognosis of EC patients. Furthermore, the guiding value of m6A‐modified ferroptosis‐related lncRNA (mfrlncRNA) features was assessed in terms of prognosis, immune microenvironment, and drug sensitivity.MethodOur research harnessed gene expression data coupled with clinical insights derived from The Cancer Genome Atlas (TCGA) collection. To forge prognostic models, we adopted five machine learning approaches, assessing their efficacy through C‐index and time‐independent ROC analysis. We pinpointed prognostic indicators using the LASSO Cox regression approach. Moreover, we delved into the biological and immunological implications of the discovered lncRNA prognostic signatures.ResultsThe survival rate for the low‐risk group was markedly higher than that for the high‐risk group, as evidenced by a significant log‐rank test (p < 0.001). The LASSO Cox regression model yielded concordance indices of 0.76 for the training set and 0.77 for the validation set, indicating reliable prognostic accuracy. Enrichment analysis of gene functions linked the identified signature predominantly to endopeptidase inhibitor activity, highlighting the signature's potential implications. Additionally, immune function and drug density emphasized the importance of early diagnosis in EC.ConclusionFive hub lncRNAs in EC were identified through constructing the prognosis model. Those genes might be potential biomarkers to provide valuable reference for targeted therapy and prognostic assessment of EC.
Attribute expansion relation extraction approach for smart engineering decision‐making in edge environments
Authors: Cui Mengmeng , Zhang Yuan , Hu Zhichen , Bi Nan , Du Tao , Luo Kangrong , Liu Juntong 
Published: September 2024

SummaryIn sedimentology, the integration of intelligent engineering decision‐making with edge computing environments aims to furnish engineers and decision‐makers with precise, real‐time insights into sediment‐related issues. This approach markedly reduces data transfer time and response latency by harnessing the computational power of edge computing, thereby bolstering the decision‐making process. Concurrently, the establishment of a sediment knowledge graph serves as a pivotal conduit for disseminating sediment‐related knowledge in the realm of intelligent engineering decision‐making. Moreover, it facilitates a comprehensive exploration of the intricate evolutionary and transformative processes inherent in sediment materials. By unveiling the evolutionary trajectory of life on Earth, the sediment knowledge graph catalyzes a deeper understanding of our planet's history and dynamics. Relationship extraction, as a key step in knowledge graph construction, implements automatic extraction and establishment of associations between entities from a large amount of sedimentary literature data. However, sedimentological literature presents multi‐source heterogeneous features, which leads to a weak representation of hidden relationships, thus decreasing the accuracy of relationship extraction. In this article, we propose an attribute‐extended relation extraction approach (AERE), which is specifically designed for sedimentary relation extraction scenarios. First, context statements containing sediment entities are obtained from the literature. Then, a cohesive hierarchical clustering algorithm is used to extend the relationship attributes between sediments. Finally, mine the relationships between entities based on AERE. The experimental results show that the proposed model can effectively extract the hidden relations and exhibits strong robustness in dealing with redundant noise before and after sentences, which in turn improves the completeness of the relations between deposits. After the relationship extraction, a proprietary sediment knowledge graph is constructed with the extracted triads.
Artificial intelligence detection of cognitive impairment in older adults during walking
Authors: Obuchi Shuichi P. , Kojima Motonaga , Suzuki Hiroyuki , Garbalosa Juan C. , Imamura Keigo , Ihara Kazushige , Hirano Hirohiko , Sasai Hiroyuki , Fujiwara Yoshinori , Kawai Hisashi 
Published: September 2024

AbstractINTRODUCTIONTo detect early cognitive impairment in community‐dwelling older adults, this study explored the viability of artificial intelligence (AI)‐assisted linear acceleration and angular velocity analysis during walking.METHODSThis cross‐sectional study included 879 participants without dementia (female, 60.6%; mean age, 73.5 years) from the 2011 Comprehensive Gerontology Survey. Sensors attached to the pelvis and left ankle recorded the triaxial linear acceleration and angular velocity while the participants walked at a comfortable speed. Cognitive impairment was determined using Mini‐Mental State Examination scores. Deep learning models were used to discern the linear acceleration and angular velocity data of 12,302 walking strides.RESULTSThe models’ average sensitivity, specificity, and area under the curve were 0.961, 0.643, and 0.833, respectively, across 30 testing datasets.DISCUSSIONAI‐enabled gait analysis can be used to detect signs of cognitive impairment. Integrating this AI model into smartphones may help detect dementia early, facilitating better prevention.Highlights
Artificial intelligence (AI)‐enabled gait analysis can be used to detect the early signs of cognitive decline.
This AI model was constructed using data from a community‐dwelling cohort.
AI‐assisted linear acceleration and angular velocity analysis during gait was used.
The model may help in early detection of dementia.
Aryl‐Fluorocyclopropane β‐Lactams with Activity Against Mycobacteroides abscessus and Mycobacterium bovis BCG
Authors: Spurling Dominic E. , Baker Emily J. , Kingsley‐Moore George , Ppadath Rifahath Mon Neyya , More Nachiket D. , Al‐Maharik Nawaf , Harrison James , Cox Jonathan A. G. , O'Hagan David 
Published: September 2024

AbstractA novel series of aryl‐α‐fluorocyclopropyl 1 and α,β,β‐trifluorocyclopropyl 2 β‐lactams have been prepared and their activity explored across various Mycobacteria and also the ESKAPE panel of pathogens. The most active of these compounds 1 a displayed good activity against clinically challenging Mycobacteria such as M. bovis BCG (MIC 0.39 mg/mL)) and did not show any significant activity against the ESKAPE pathogens indicating selectivity for this otherwise challenging class of pathogen. Compound 1 a was however rapidly metabolised and toxic to a human model cell line (HepG2) limiting its clinical development at this stage. The compounds were designed to exploit a fluoride ion elimination mechanism concomitant with β‐lactam ring opening, as the basis of a mechanism induced trigger to generate a reactive intermediate (suicide inhibition). In model alkoxide reactions a representative from both classes 1 and 2 resulted in β‐lactam ring opening but only the more active mono‐fluoro cyclopropane series 1 triggered fluoride ion elimination after ring opening and this may form the basis of its activity.
A multicultural comparative study of self‐stigma in epilepsy: Differences across four cultures
Authors: Iwayama Takayuki , Mizuno Kimihito , Yildiz Esra , Lim Kheng‐Seang , Yi Soon Ming , Lynn Yee Joe , Hin Ching Woon , Jean Jason Chia Zhi , Fong Si‐Lei , Xuen Yu , Qian Ong Zhi , Kuramochi Izumi 
Published: September 2024

AbstractObjectiveEpilepsy is a neurological disorder characterized by recurrent seizures, exhibiting variance in prevalence and treatment availability across diverse geopolitical contexts and cultural milieus. The stigma associated with epilepsy is a significant global issue affecting the quality of life (QOL) of people with epilepsy (PWE). This study aims to examine the relationship between self‐stigma and depressive symptoms in PWE, with a particular emphasis on understanding the manifestations of these across different cultural contexts. We aim to enhance the provision of customized care to diverse cultural settings, fostering the adoption of healthier lifestyles for PWE.MethodsWe recruited PWE who received treatment at specialized medical facilities for epilepsy in Japan, Malaysia (Chinese, Malay), and Turkey from February to October 2023. The Epilepsy Self‐Stigma Scales (ESSS), Neurological Disorders Depression Inventory for Epilepsy (NDDI‐E), and Generalized Anxiety Disorder 7 (GAD‐7) in local languages were used to assess self‐stigma, depressive symptoms, and anxiety.ResultsThe ESSS total scores were significantly higher among the Turkish and Japanese cohorts (F [3, 406] = 6.57, p < 0.001, η2 = 0.05). In addition, the self‐stigma observed moderate positive correlations for depressive symptoms (rs = 0.41–0.50, Ps < 0.001) and anxiety (rs = 0.42–0.44, Ps < 0.001). The ANCOVA findings suggested that the notable variations in self‐stigma, as found in the one‐way ANOVA conducted across four cultures, were reduced when taking into consideration depressed symptoms. Our finding highlights the potential influence of mental health factors over cultural factors concerning self‐stigma.SignificanceThe manifestation of self‐stigmatization within epilepsy exhibits distinctions across diverse cultural cohorts, regardless of the demographic and clinical variation, yet demonstrates a significant correlation with psychological factors. In subsequent research endeavors, we should comprehensively investigate these subtle differences, their potential impact on patient care, and the development of supportive approaches.Plain Language SummaryThis cross‐cultural study reveals significant variations in self‐stigma among people with epilepsy across different cultural contexts, with Turkish and Japanese cohorts showing higher levels. Self‐stigma demonstrated moderate positive correlations with depressive symptoms and anxiety across all cultures. Notably, differences in self‐stigma were reduced when accounting for depressive symptoms, suggesting that mental health factors may have a stronger influence than cultural factors. These findings underscore the importance of considering both cultural and psychological aspects in developing targeted interventions to address self‐stigma in epilepsy care.
Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing
Authors: Li Wei , Chen Junxia , Qin Yingjie , Jiang Sisi , Li Xiuli , Zhang Heng , Luo Cheng , Gong Qiyong , Zhou Dong , An Dongmei 
Published: September 2024

AbstractObjectiveDystonic posturing (DP) is a common semiology in temporal lobe epilepsy (TLE). We aimed to explore cerebellar gradient alterations in functional connectivity in TLE patients with and without DP.MethodsResting‐state functional MRI data were obtained in 60 TLE patients and 32 matched healthy controls. Patients were further divided into two groups: TLE with DP (TLE + DP, 31 patients) and TLE without DP (TLP‐DP, 29 patients). We explored functional gradient alterations in the cerebellum based on cerebellar–cerebral functional connectivity and combined with independent component analysis to evaluate cerebellar–cerebral functional integration and reveal the contribution of the motor components to the gradient.ResultsThere were no obvious differences in clinical features and postoperative seizure outcomes between TLE + DP and TLE‐DP patients. Patients and controls all showed a clear unimodal‐to‐transmodal gradient transition in the cerebellum, while TLE patients demonstrated an extended principal gradient in functional connectivity compared to healthy controls, which was more limited in TLE + DP patients. Gradient alterations were more widespread in TLE‐DP patients, involving bilateral cerebellum, while gradient alterations in TLE + DP patients were limited in the cerebellum ipsilateral to the seizure focus. In addition, more cerebellar motor components contributed to the gradient alterations in TLE + DP patients, mainly in ipsilateral cerebellum.SignificanceExtended cerebellar principal gradients in functional connectivity revealed excessive functional segregation between unimodal and transmodal systems in TLE. The functional connectivity gradients were more limited in TLE + DP patients. Functional connectivity in TLE patients with dystonic posturing involved more contribution of cerebellar motor function to ipsilateral cerebellar gradient.Plain Language SummaryDystonic posturing contralateral to epileptic focus is a common symptom in temporal lobe epilepsy, and the cerebellum may be involved in its generation. In this study, we found cerebellar gradients alterations in functional connectivity in temporal lobe epilepsy patients with and without contralateral dystonic posturing. In particular, we found that TLE patients with dystonic posturing may have more limited cerebellar gradient in functional connectivity, involving more contribution of cerebellar motor function to ipsilateral cerebellar gradient. Our study suggests a close relationship between ipsilateral cerebellum and contralateral dystonic posturing.
Superior prognostic accuracy of FIGO staging system in primary female genital tract lymphomas: A retrospective study (IELSG35)
Authors: Pirosa Maria Cristina , Steffanoni Sara , Vanazzi Anna , Esposito Fabiana , Polino Angela , Schena Alberto , Landi Francesco , Cabrera Maria Elena , Akhtar Saad , Gardella Santiago , Bairey Osnat , Pavlovsky Astrid , Stathis Anastasios , Zucca Emanuele 
Published: September 2024

AbstractPrimary lymphoma of the female genital tract (PLFGT) is a rare type of extranodal lymphoma. In this retrospective study from the International Extranodal Lymphoma Study Group, we analyzed clinical data from 60 women diagnosed with PLFGT between 1982 and 2012. The median age was 52 years. Limited stage, as defined by the Ann Arbor and FIGO staging systems, was observed in 55% and 63% of cases, respectively. The uterus was the primary site of lymphoma in 25 cases, with the ovaries as the second most common site (n = 24). The most common histological subtype was diffuse large B‐cell lymphoma (DLBCL, n = 44), followed by follicular lymphoma and marginal zone lymphoma (6 patients each). Two patients received surgery alone as first‐line therapy, while 58 underwent systemic therapy, 16 following major surgery. Thirteen patients received consolidation radiotherapy and six were given central nervous system (CNS) prophylaxis. Twenty patients had disease progression or recurrence. Six patients with DLBCL (14%) experienced CNS relapse, which was the only site of recurrence in five of them. All but one patient with CNS relapse had primary ovarian involvement, and three had bulky disease; none of these patients had received CNS prophylaxis. With a median follow‐up of 60 months, the median overall survival of the DLBCL cohort was approximately 13 years, with a 5‐year survival rate of 77%. In multivariable analysis, advanced disease according to the FIGO system was the only parameter significantly associated with shorter overall, cause‐specific, and progression‐free survival in patients with DLBCL.
Impact of extrathyroidal autoimmune diseases on clinical features and the efficacy of Iodine‐131 therapy in patients with differentiated thyroid cancer
Authors: Long Ya‐hong , Li Na , Ma Le , Zhang Wan‐chun 
Published: September 2024

AbstractObjectiveThe aim of this study is to assess the impact of extrathyroidal autoimmune diseases (ADs) on the clinical characteristics and efficacy of iodine‐131 (131I) therapy in patients with differentiated thyroid cancer (DTC).MethodsPatients with DTC who were received 131I therapy simultaneously were classified into the combination group (n = 35) and noncombination group (n = 146) depending on the presence of ADs. The clinical characteristics, such as gender, age, tumor lesions, lymph node metastasis, distant metastasis, 131I therapy efficacy, and use of levothyroxine, were compared between the two groups. Statistical analysis was conducted using SPSS 26.0 and R 4.0.3.ResultsThere was a statistically significant difference in age between the combination and noncombination groups (t = −2.872, p < .01), and the optimal cutoff value was 50.5 years. Propensity score matching was completed effectively on a total of 121 patients, using age as the matching factor, comprising 32 cases in the combination group and 80 cases in the noncombination group. The baseline demographic features of the two groups were equivalent after matching (p > .05), and there was no significant difference in the therapeutic efficacy of 131I between the two groups (p > .05). In the subgroup analysis involving patients aged great than 50.5 years, the levothyroxine/weight (µg/kg) was increased in the combination group, and the difference was statistically significant (p < .05).ConclusionWhile extrathyroidal ADs may enhance the detection of DTC among elderly women, they have no impact on the clinical characteristics of thyroid cancer or the efficacy of 131I therapy. ADs may necessitate higher per‐unit dosages of levothyroxine in patients with DTC, regardless of the clinical status. Consequently, it is not essential for nuclear medicine physicians to consider the presence of ADs when designing treatment plans for patients with DTC.
Mitochondrial metabolism: A moving target in hepatocellular carcinoma therapy
Authors: Komza Monika , Chipuk Jerry Edward 
Published: September 2024

AbstractMitochondria are pivotal contributors to cancer mechanisms due to their homeostatic and pathological roles in cellular bioenergetics, biosynthesis, metabolism, signaling, and survival. During transformation and tumor initiation, mitochondrial function is often disrupted by oncogenic mutations, leading to a metabolic profile distinct from precursor cells. In this review, we focus on hepatocellular carcinoma, a cancer arising from metabolically robust and nutrient rich hepatocytes, and discuss the mechanistic impact of altered metabolism in this setting. We provide distinctions between normal mitochondrial activity versus disease‐related function which yielded therapeutic opportunities, along with highlighting recent preclinical and clinical efforts focused on targeting mitochondrial metabolism. Finally, several novel strategies for exploiting mitochondrial programs to eliminate hepatocellular carcinoma cells in metabolism‐specific contexts are presented to integrate these concepts and gain foresight into the future of mitochondria‐focused therapeutics.
No difference in laxity, proprioception and neuromuscular control after suture‐tape augmented ACL repair of acute proximal avulsions versus ACL reconstruction using hamstring autografts in young, active population
Authors: Góralczyk Adrian , Zalewska Paulina , Piszczatowski Szczepan , Hermanowicz Krzysztof , Guszczyn Tomasz 
Published: September 2024

AbstractPurposeThe purpose of this study is to compare results of suture‐tape augmented anterior cruciate ligament (ACL) repair (internal bracing [IB]) and ACL reconstruction (ACLR) with hamstring autograft in terms of laxity, proprioception and neuromuscular control. The hypothesis was that with strict indications IB may provide better results in proprioception and neuromuscular control.MethodsPatients with unilateral ACL injury treated with IB or ACLR with hamstring autograft were enroled in this retrospective study. Anterior tibial translation (ATT) in 30° and 90° of flexion was measured with Rolimeter. The joint position sense (JPS) test was performed in 30° and 60° of flexion using Biodex System 4Pro. The time‐synchronized motion capture system and surface electromyography set were used during dynamic tasks to assess knee valgus and semitendinosus (ST) and biceps femoris (BF) activities. Comparisons between both techniques and operated versus contralateral healthy knees were performed.ResultsThe study groups involved 28 patients after ACLR (21.8 ± 4.8 years) and 20 patients after IB (25.8 ± 10.5 years) with the average follow‐up 30 ± 18 and 28 ± 15 months, respectively. The ATT did not differ significantly between operated groups. In 30° of flexion ATT for ACLR was significantly higher in operated than in contralateral knee (5.8 ± 2.4 mm vs. 4.3 ± 1.3 mm, p < 0.001). The JPS test and dynamic knee valgus presented no significant differences. The ACLR group presented significantly higher ST (p = 0.048) and BF (p = 0.012) activity comparing operated to contralateral knee in dynamic tasks.ConclusionSuture‐tape augmented ACL repair and ACLR with hamstring autograft yield similar results in terms of laxity, proprioception and neuromuscular control.Level of EvidenceLevel III: Retrospective comparative study.