bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mantodea phylogenomics provides new insights into X-chromosome progression and evolutionary radiation
Authors: Liu Hangwei , Lei Lihong , Jiang Fan , Zhang Bo , Wang Hengchao , Zhang Yutong , Wang Anqi , Zhao Hanbo , Wang Guirong , Fan Wei 
Published: October 2024

Abstract

Background
Praying mantises, members of the order Mantodea, play important roles in agriculture, medicine, bionics, and entertainment. However, the scarcity of genomic resources has hindered extensive studies on mantis evolution and behaviour.
Results
Here, we present the chromosome-scale reference genomes of five mantis species: the European mantis (Mantis religiosa), Chinese mantis (Tenodera sinensis), triangle dead leaf mantis (Deroplatys truncata), orchid mantis (Hymenopus coronatus), and metallic mantis (Metallyticus violaceus). We found that transposable element expansion is the major force governing genome size in Mantodea. Based on whole-alignments, we deduced that the Mantodea ancestor may have had only one X chromosome and that translocations between the X chromosome and an autosome may have occurred in the lineage of the superfamily Mantoidea. Furthermore, we found a lower evolutionary rate for the metallic mantis than for the other mantises. We also found that Mantodea underwent rapid radiation after the K-Pg mass extinction event, which could have contributed to the confusion in species classification.
Conclusions
We present the chromosome-scale reference genomes of five mantis species to reveal the X-chromosome evolution, clarify the phylogeny relationship, and transposable element expansion.
Gyral Peaks Reveal Brain Function Disparities in Diverse Social Environments
Authors: Cao Guannan , zhang Songyao , He Zhibin , Wang Zifan , Guo Lei , Yan Zhiqiang , Han Junwei , Jiang Xi , Zhang Tuo 
Published: October 2024

Abstract

Different social environments play a important role in shaping brain structure and function. Many attempts have been undertaken to connect environmental variations with brain function, which, however, fluctuates over time and is costly, limiting its utility to identify consistent brain markers as well as its application to a broad population. In contrast, brain anatomy is less altered during a short period of time, but it is not fully understood whether it could serve as the environment-sensitive landmark, or its variation is associated with functional one. In this study, we utilized gyral peaks, one group of the early cortical folds, as cortical landmarks, to investigate the environmental influence on brain anatomy, as well as its relation to function and the interpretation from the genetic aspect. Comparative experiments were conducted on two large neuroimaging dataset, Human Connectome Project and Chinese Human Connectome Project, with significant diversity of social environment. We identified peaks that are shared between the two groups and those unique to each of them. In contrast to the shared ones, the unique peaks exhibit significant between-group differences in terms of cortical and functional network attributes, and arespatially associated with working memory networks which are more activated with the presence of these peaks. This result gains supports from gene enrichment analysis where the presence of these peaks are found to regulated by genes related to working memory functions. These findings could provide new knowledge to understanding how environments interplay with brain functions and associate with brain shapes.
First Proof of Principle Experiment for Muon Production with Ultrashort High Intensity Laser
Authors: Gu Yuqiu , Zhang Feng , Deng Li , Ge Yanjie , Wen Jiaxing , Cui Bo , Feng Ke , Wang Hao , Wu Chen , Pan Ziwen , Liu Hongjie , Deng Zhigang , Zhang Zongxin , Chen Liangwen , YAN Duo , Shan Lianqiang , Yuan ZQ , Tian C. , Qian Jiayi , Zhu JiaCheng , Xu Yi , Yu Yuhong , Zhang Xueheng , Yang Lei , Zhou Weimin , Wang Wentao , Leng Yuxin , Sun Zhiyu , Li Ruxin 
Published: October 2024

Abstract

Muons, which play a crucial role in both fundamental and applied physics, have traditionally been generated through proton accelerators or from cosmic rays. With the advent of ultra-short high-intensity lasers capable of accelerating electrons to GeV levels, it has become possible to generate muons in laser laboratories. In this work, we show the first proof of principle experiment for novel muon production with an ultra-short, high-intensity laser device through GeV electron beam bombardment on a lead converter target. The muon physical signal is confirmed by measuring its lifetime which is the first clear demonstration of laser-produced muons. Geant4 simulations were employed to investigate the photo-production, electro-production, and Bethe-Heitler processes response for muon generation and their subsequent detection. The results show that the dominant contributions of muons are attributed to the photo-production/electro-production and a significant yield of muons up to 0.01 μ/e- out of the converter target could be achieved. This laser muon source features compact, ultra-short pulse and high flux. Moreover, its implementation in a small laser laboratory is relatively straightforward, significantly reducing the barriers to entry for research in areas such as muonic X-ray elemental analysis, muon spin spectroscopy and so on.
Biocontrol efficacy of Trichoderma isolates in controlling aflatoxinogen fungi (Aspergillus flavus) and growth promoting of maize in Cameroun
Authors: ABOUNA EDMOND NOEL MENYE , KUNT Keziban Sinem TULUKOĞLU , unlu Nida UYSAL , BEGOUDE Didier , Onana boyomo , SERCE Cigdem ULUBAS 
Published: October 2024

Abstract

Maize is a significant cereal crop, serving as a dietary staple and an indispensable raw material for industrial use in Cameroon. Aflatoxinogen fungi (Aspergillus spp), an opportunistic plant microorganism, alter by mycotoxin the biochemical components in maize during processing and storage, causing post-harvest losses and compromising food safety. The use of Trichoderma spp as a biological control agent against aflatoxigenic fungi and as a fertilizer has long been proven in agriculture by numerous researchers. This study aimed to isolate and characterize Trichoderma spp from maize rhizosphere soil and assess its potential for biological control of Aspergillus spp isolated from maize seeds and for promoting the growth of maize. Isolation and sequencing showed that our isolates were Trichoderma harzianum for CR-TS1 and T. ghanense for CR-TS3, CR-TS4, and CR-TC1. When tested directly against A. flavus on a PDA medium, the Trichoderma spp inhibited growth with percentages of 78.83%, 77.01%, 75,88%, and 74,95% for CR-TS1, CR-TS3, CR-TC1, and CR-TS4 respectively. Similarly, to verify our isolates' capacity to secrete volatile compounds, a remote confrontation test was carried out by contrasting Trichoderma spp and Aspergillus spp. The results of this test demonstrated the secretion of volatile compounds by our Trichoderma spp with inhibition of 40.94%, 29.48%, 34.36, and 32.19% respectively for CR-ST1, CR-ST3, CR-TC1, and CR-TS4. Our study also showed that isolated Trichoderma spp can produce extracellular enzymes such as amylase, protease, and lignase. Similarly, the phosphate solubilization test on Pikovskaya (PVK) medium and the siderophore test on chrome azurol S (CAS) agar medium using our Trichoderma spp isolates were all positive, with halo formation around the colony for phosphate solubilization and a color change from blue to yellow for the siderophore. IAA, one of the phytohormones essential not only for the microorganism but also for the plant, tested positive on PDB medium supplemented with L-tryptophan. Similarly, the application of 107 spores/ml of suspension to maize seeds in vitro significantly (p < 0.05) boosted maize germination from 90 to 100% compared with the control, which was at 80%. The results of pot experiments carried out to assess the growth promotion effect of our isolates showed a significant increase in plant size, root length, dry and fresh weight of plants and roots, as well as chlorophyll production. All these results show that our isolates can be used in agriculture as a biocontrol agent for aflatoxinogenic fungi and as a fertilizer.
Biochanin A has anti-inflammatory effects on diet-induced obesity and ovariectomy in mice
Authors: Aragão Jéssica Maria Dantas Araújo , Heimfarth Luana , Neres Wemerson de Santana , Félix Franciel Batista , Santos Patrícia Rabelo dos , Abreu Fabíula Francisca , Cercato Luana Mendonça , Nascimento Ana Carla Silva , Vasconcelos Alan Bruno Silva , Soares Rosilene Calazans , Júnior Ricardo Luiz Cavalcanti de Albuquerque , Heiden Greice Itamaro , de Moura Tatiana Rodrigues , Camargo Enilton Aparecido , Grespan Renata 
Published: October 2024

Abstract

Biochanin A (BCA) is a phytoestrogen widely studied for its ability to alleviate menopausal symptoms and treat metabolic diseases in the presence or absence of estrogen. This study was conducted to investigate the effect of BCA in ovariectomized (OVX) mice subjected to a high-fat diet (HFD). To this end, female C57BL6 mice were randomly divided into 5 groups: SHAM (sham-operated) with HFD, OVX with a standard diet (SD) or HFD, and two other OVX groups with HFD treated with BCA (2 mg/kg or 6 mg/kg, i.p.) during the last 30 days. The experiment lasted 15 weeks, after which it was observed that the OVX HFD animals presented a compromised metabolic profile compared to the SHAM HFD or OVX SD animals. When evaluating the BCA-treated groups in comparison to the OVX HFD group, it was demonstrated that there was less inflammation in the AT due to the reduction in crown-like structures (CLS) and the increase in the adipocyte area. This effect was complemented by an increase in the levels of the cytokines IL-5 and IL-10 and an increase in the expression of Mrc1, a marker of M2 macrophages, and Pparγ, a key regulator of tissue metabolism. Furthermore, in the liver, BCA reduced the degree of hepatic steatosis and the expression of Nos2. We concluded that BCA exerted an anti-inflammatory response in the liver, particularly in the AT, indicating a resolution profile despite not altering the animals' metabolic profile. This study demonstrated, for the first time, the anti-inflammatory effect of BCA on tissues affected by lipotoxicity caused by high-fat diet consumption, exacerbated by ovariectomy.
Targeting Hydrophobic Residues in the Alpha-Synuclein NAC Domain Disrupts Aggregation and Seed-Competent Fibril Formation
Authors: Das Viswanath , Mousavi Sayed Mostafa Modarres , Annadurai Narendran , Moradi Sajad , Malina Lukáš , Kolaříková Markéta , Ranc Vaclav , Frydrch Ivo , Kouřil Roman , Hosseinkhani Saman , Hajdúch Marián , Nikkhah Maryam 
Published: October 2024

Abstract

Alpha-synuclein (αSyn) is a 14 kDa soluble and intrinsically disordered protein ubiquitously expressed in neurons. It plays a crucial role in synucleinopathies, where insoluble fibrils contribute to neurotoxicity and disease progression. The formation of these fibrils and their ability to seed further aggregation are central to αSyn pathology. Our study focused on the hydrophobic non-amyloid component (NAC) region of αSyn. Using full-length NAC peptide and its truncated variants, inhibitory peptides, and a combination of experimental and computational approaches, we demonstrate that the 68GAVV71 region and residues adjacent to it, such as T72, T75, and A76, are essential for αSyn aggregation and its prion-like behavior. Inhibitor peptides that target the hydrophobic region effectively block αSyn dimerization and aggregation into seed-competent fibrils. Molecular dynamics simulations revealed that the peptide inhibitor disrupted hydrophobic interactions within the NAC domain, preventing stable β-sheet structure formation. These results show that the 68GAVV71 stretch in the NAC domain is critical for αSyn aggregation into prion-like fibrils and could be a potential molecular target for treating synucleinopathies.
Glaucoma epidemiology in the Russian Federation
Authors: Neroev V. V. , Mikhaylova L. A. , Malishevskaya T. N. , Petrov S. Yu. , Filippova O. M. 
Published: October 2024

Glaucoma is worldwide the most common cause of irreversible blindness. Its prevalence in the population older than 40 years is about 3.5 %, and correlates with age. The most common type is primary open-angle glaucoma (POAG). The global prevalence of POAG is expected to grow from 76.0 million in 2020 to 111.8 million by 2040. In 2022, a total of 1,250,558 patients with glaucoma were registered in the Russian Federation, of which 110,680 had newly diagnosed glaucoma. The overall glaucoma incidence rate in Russia shows a steady growth: in 2022, it increased by 30 % as compared to 2013. In order to meet the challenge, medical care of glaucomatous patients is on the rise: the contingent receiving dispensary observation increased by 6.8 % over the last 10 years, whilst surgical treatment involved 28.1 % more patients.
M, NM-polynomials Based on Reverse, Reduced Reverse Degree and Neighborhood Degree Based Topological Indices with Applications to
Bond Energy of Y-Junction Nanotubes
Authors: Huilgol Medha Itagi , P H Shobha , H Jayakrishna Udupa , Cangul Ismail Naci 
Published: October 2024

Background:
In graph theory, M polynomials like the matching polynomial are very
crucial in examining the matching structures within graphs, while NM polynomials extends this
to analyze non-matching edges. These polynomials are important in many fields, including
chemistry and network architecture. They support the derivation of topological indices for protein
structure analysis, network communication optimization, and drug design in QSAR/QSPR
investigations.

Objective:
The aim of this paper is to define novel M and NM polynomials for different topological
indices and to derive their closed-form expressions, specifically for Y-junction nanotubes.
These new polynomials and indices are employed to create a robust QSPR model to predict
bond energy in Y-junction nanotubes, that provide high accuracy and reliability in the model's
statistical performance.

Method:
This paper introduces new forms of M and NM polynomials tailored to specific topological
indices related to reverse and neighborhood reverse properties. We derive closed-form
expressions for these indices in Y-junction nanotubes. Furthermore, we develop a QSPR model
to predict bond energy in Y-junction nanotubes using the newly defined indices.

Result:
We define novel M and NM polynomials for various topological indices and derive precise
expressions for Y-junction nanotubes. Utilizing these indices, we construct a highly accurate
QSPR model (R² = 0.999) for predicting bond energy in Y-junction nanotubes, confirming
the validity of our polynomial definitions and indices.

Conclusion:
We have presented new M and NM polynomials for different topological indices
and derive their expressions specifically for Y-junction nanotubes. With these newly defined indices,
we have developed a highly precise QSPR model to predict bond energy, achieving an R²
value of 0.999. This work underscores the effectiveness of our polynomial definitions and indices
in predicting material properties.
Combination of Different Sectional Elastography Techniques with Age to Optimize the Downgrading of Breast BI-RAIDS Class 4a Nodules
Authors: Jiang Xianxian , Chen Le-yuan , Li Juan , Chen Fang-yuan , He Nian-an , Ye Xian-jun 
Published: October 2024

Objective:
This study aims to optimize the downgrading of BI-RADS class 4a nodules by combining various sectional elastography techniques with age

Materials and Methods:
We performed conventional ultrasonography, strain elastography (SE), and shear wave elastography (SWE) on patients. Quantitative parameters
recorded included age, cross-sectional and longitudinal area ratios (C-EI/B, L-EI/B), strain rate ratios (C-SR, L-SR), overall average elastic
modulus values (C-Emean1, L-Emean1), five-point average elastic modulus values (C-Emean2, L-Emean2), and maximum elastic modulus values
(C-Emax, L-Emax).

Results:
Histopathological evaluations showed that out of 230 lesions, 45 were malignant, and 185 were benign. The sensitivity and specificity of
conventional ultrasonography were 100% and 0%, respectively. In contrast, SE and SWE exhibited higher specificity but lower sensitivity. Crosssectional
parameters (C-EI/B, C-SR, C-Emean1, C-Emean2, and C-Emax) outperformed their longitudinal counterparts, with C-SR and C-Emax
showing the highest specificity (72.43% and 73.51%) and satisfactory sensitivity (80.00% and 88.89%). Combining age with C-SR and C-Emax
significantly improved diagnostic efficiency, achieving a sensitivity of 97.78% and a specificity of 77.30%.

Conclusion:
Integrating age with C-SR and C-Emax effectively reduces unnecessary biopsies for most BI-RADS 4a benign lesions while maintaining a very
low misdiagnosis rate.
Prenatal Three-Dimensional Ultrasound Diagnosis of Dural Sinus Arteriovenous Malformation: An Unusual Case Report
Authors: Qiu Li , Chen Huizhu , Chen Ni , Luo Hong 
Published: October 2024

Background:
Dural sinus arteriovenous malformation is an uncommon intracranial vascular malformation. The affected cases may suffer from severe
neurological injury. Prenatal ultrasound has been used to diagnose fetal intracranial vascular abnormality, but prenatal three-dimensional (3D)
ultrasound presents a very rare anomaly; an arteriovenous malformation of the dural sinus has not been reported.

Objective:
This study aimed to emphasize the diagnostic value of 3D ultrasound in the fetus with dural sinus arteriovenous malformation.

Case Presentation:
A 38-year-old woman was referred for targeted fetal ultrasonography at 37 weeks of gestation due to an ultrasound that showed a cystic lesion in
the posterior cranial fossa. The fetus demonstrated obvious dilatation of the torcular herophili, bilateral transverse sinuses, and bilateral sigmoid
sinuses, appearing as a novel bull's horn sign on 3D ultrasound. After birth, cerebral angiography confirmed the diagnosis of dural arteriovenous
fistula (DAVF) in the occipital sinus region.

Conclusion:
3D ultrasound is an appealing method for prenatal diagnosis of dural sinus arteriovenous malformation.
Research on Quadruped Crawling Robot Control with Finite-Time Observer in Continuous Convex Terrain
Authors: Zhang Peng , Nan FangHao , Liu LuYu , Wang Peng 
Published: October 2024

Background:
In recent years, observers have been crucial for controlling quadruped
crawling robots, especially for feed-forward compensation in complex terrains. However, their tracking
performance in continuous convex terrains requires optimization.

Objective:
In order to improve the mobility of quadruped crawling robots by reducing posture adjustment
time in continuous convex terrain, a finite-time observer with integration elements and optimized
gait planning is proposed.

Methods:
First, a buffer phase is introduced into the tripod gait planning to adapt to terrain changes,
and the velocity error of the robot's center of mass is analyzed. Second, a coupled robot dynamics
model is developed and the disturbance component structure is derived to ensure accurate estimation
of the system state, especially in maintaining stability in the face of external disturbances. Finally,
the auxiliary variable of the observer is based on the velocity error, with disturbance estimation terms
combining power and sign functions, and the cumulative error is introduced by integrating the adjustment
functions to improve the tracking performance.

Results:
The proposed observer reduces the maximum estimation error at knee and hip joints by 0.63
and 0.425 degrees, respectively, compared to a non-integrated observer. The integral of the absolute
error during leg swing is 17.44% to 35.04% of the latter's, and the integral of the squared deviation
error is 1.90% to 8.38%. These results demonstrate that the proposed observer can track the state
information of the robot with greater accuracy.

Conclusion:
The proposed finite-time observer significantly improves motion control for robots in
continuous convex terrain and offers insights for enhancing stability in complex environments,
which is expected to address the challenges of other robotic manipulator systems in overcoming the
effects of external disturbances.
Impact of Video-Based Error Correction Learning for Cardiopulmonary Resuscitation Training: Quasi-Experimental Study
Authors: Wang Yun , Fu Junzuo , Wang Shaoping , Wang Huijuan , Gao Wei , Huang Lina 
Published: October 2024

Abstract

Background
Video-based error correction (VBEC) in medical education could offer immediate feedback, promote enhanced learning retention, and foster reflective practice. However, its application in cardiopulmonary resuscitation (CPR) training has not been investigated.

Objective
The objective of this study is to assess whether the VBEC procedure could improve the training performance of CPR among anesthesiology residents.

Methods
A quasi-experimental study was conducted among anesthesiology residents between December 2022 and April 2023. Primary outcomes included a posttraining knowledge test and practical assessment scores. Secondary outcomes included the number of residents who correctly conducted CPR at each step, the rate of common mistakes during the CPR process, and the self-assessment results. A total of 80 anesthesiology residents were divided into a VBEC group (n=40) and a control group (n=40). The VBEC group underwent a 15-minute VBEC CPR training, whereas the control group underwent a 15-minute video-prompting CPR training.

Results
The posttraining knowledge test score of the VBEC group was significantly higher than that of the control group (73, SD 10.5 vs 65.1, SD 11.4; P=.002). The residents in the VBEC group had lower error rates in “failure to anticipate the next move” (n=3, 7.5% vs n=13, 32.5%; P=.01) and “failure to debrief or problem solve after the code” (n=2, 5% vs n=11, 27.5%; P=.01), as well as better performance in the “secure own safety” step (n=34, 85% vs n=18, 45%; P<.001) than those in the control group. The VBEC group showed significantly higher confidence in CPR than the control group (n=?, 62.5% vs n=?, 35%; P=.03).

Conclusions
VBEC may be a promising strategy compared to video prompting for CPR training among anesthesiology residents.
Ignorance Is Bliss: The Screening Effect of (Noisy) Information
Authors: Feng Felix Zhiyu , Wang Wenyu , Wu Yufeng , Zhang Gaoqing 
Published: October 2024

ABSTRACT
This paper studies the value of a firm’s internal information when the firm faces an adverse selection problem arising from unobservable managerial abilities. Although more precise information allows the firm to make ex post more efficient investment decisions, noisier information has an ex ante screening effect that allows the firm to attract on-average better managers. The tradeoff between more effective screening of managers and more informed investment implies a nonmonotonic relationship between firm value and information quality. A marginal improvement in information quality does not necessarily lead to an overall improvement in firm value.
JEL Classifications: M41; D82; G34.