bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopic percutaneous inverted mattress suture fixation of isolated greater tuberosity fracture of humerus
Authors: Jang Suk-Hwan , Song Han-Eui , Choi Seung-Hyuk 
Published: January 2018

Objective: The purpose of the study was to evaluate the clinical and radiographic outcomes of treatment in patients with isolated greater tuberosity (GT) fractures of humerus using arthroscopic percutaneous inverted mattress suture fixation technique. Materials and methods: We attempted to use the arthroscopic percutaneous inverted mattress suture fixation technique in 17 consecutive cases with isolated displaced GT fractures. Fourteen patients were successfully treated without switching to other methods and were available for follow-up at a mean of 22 months (range: 17–38 months) after surgery. For assessment of clinical outcomes, we evaluated the range of motion and the visual analog scale (VAS) score, the shoulder index of the American Shoulder and Elbow Surgeons (ASES), and the Korean Shoulder Scale (KSS). Results: At the final follow-up, the VAS improved to 1.0 points (range: 0–3), the mean ASES score improved to 86.9 points (range: 78.3–100) and the KSS improved to 88.6 points (range: 82–100) postoperatively. Mean union time was 10 weeks. Mean forward flexion was 167.8° (range: 140–180°), mean external rotation in neutral position was 36° (range: 20–70°), and mean internal rotation was at the 12th thoracic level (range: T6–L3) at final follow-up. Three cases were switched to open surgery after attempted arthroscopic technique due to large fragment or osteoporosis. Conclusion: In select cases, the arthroscopic percutaneous inverted mattress suture fixation of GT fracture is a simple and reproducible technique with encouraging early results.
Phase 2 trial of a multivalent WT1 peptide vaccine (galinpepimut-S) in acute myeloid leukemia
Authors: Maslak Peter G. , Dao Tao , Bernal Yvette , Chanel Suzanne M. , Zhang Rong , Frattini Mark , Rosenblat Todd , Jurcic Joseph G. , Brentjens Renier J. , Arcila Maria E. , Rampal Raajit , Park Jae H. , Douer Dan , Katz Laura , Sarlis Nicholas , Tallman Martin S. , Scheinberg David A. 
Published: January 2018

Key Points
A heteroclitic WT1 peptide vaccine is well tolerated and induces immunologic responses in most acute myeloid leukemia patients post-CR1. Median overall survival for the group of patients vaccinated was not reached but is poised to reach or exceed 67.6 months.
RETRACTED ARTICLE: Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability
Authors: Lin Zhikun , He Ruiping , Luo Haifeng , Lu Chang , Ning Zhen , Wu Yuanhang , Han Chuanchun , Tan Guang , Wang Zhongyu 
Published: January 2018

Abstract
Background
The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate the interactions of cells with the extracellular matrix (ECM) and promote tumorigenesis in several malignancies. However, the role of ITGB5 in hepatocellular carcinoma (HCC) is still unknown.

Methods
The biological function of ITGB5 in HCC was investigated using migration, colony formation assays. The potential molecular mechanism of ITGB5 in regulating HCC tumorigenesis and β-catenin stabilization was investigated by western blotting, co-immunoprecipitation and ubiquitination assays. The expression level of ITGB5 mediated by miR-185 was confirmed by bioinformatic analysis, luciferase assay. The clinical significance of ITGB5 was based on human tissue microarray (TMA) analysis.

Results
Here, we found that the expression of ITGB5 is increased in HCC tissues. Elevated ITGB5 markedly facilitates HCC cell migration and tumorigenesis in vitro and in vivo. Further mechanistic studies revealed that ITGB5, as a partner of β-catenin, directly interacts with β-catenin and inhibits its degradation, thus leading to WNT/β-catenin activity. Subsequently, we also found that ITGB5 is a direct targeted gene of miR-185. The downregulation of miR-185 in HCC cells promotes an increase in ITGB5. An additional increase of ITGB5 is associated with β-catenin upregulation and a miR-185 decrease in HCC tissues.

Conclusions
Our data reveal that the miR-185-ITGB5-β-catenin pathway plays an important role in HCC tumorigenesis, and ITGB5 may be a promising specific target for HCC therapy.
Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury
Authors: Wang Guoxiang , Zhang Yi Ping , Gao Zhongwen , Shields Lisa B. E. , Li Fang , Chu Tianci , Lv Huayi , Moriarty Thomas , Xu Xiao-Ming , Yang Xiaoyu , Shields Christopher B. , Cai Jun 
Published: January 2018

ABSTRACT
Abusive head trauma (AHT) is the leading cause of death from trauma in infants and young children. An AHT animal model was developed on 12-day-old mice subjected to 90° head extension-flexion sagittal shaking repeated 30, 60, 80 and 100 times. The mortality and time until return of consciousness were dependent on the number of repeats and severity of the injury. Following 60 episodes of repeated head shakings, the pups demonstrated apnea and/or bradycardia immediately after injury. Acute oxygen desaturation was observed by pulse oximetry during respiratory and cardiac suppression. The cerebral blood perfusion was assessed by laser speckle contrast analysis (LASCA) using a PeriCam PSI system. There was a severe reduction in cerebral blood perfusion immediately after the trauma that did not significantly improve within 24 h. The injured mice began to experience reversible sensorimotor function at 9 days postinjury (dpi), which had completely recovered at 28 dpi. However, cognitive deficits and anxiety-like behavior remained. Subdural/subarachnoid hemorrhage, damage to the brain-blood barrier and parenchymal edema were found in all pups subjected to 60 insults. Proinflammatory response and reactive gliosis were upregulated at 3 dpi. Degenerated neurons were found in the cerebral cortex and olfactory tubercles at 30 dpi. This mouse model of repetitive brain injury by rotational head acceleration-deceleration partially mimics the major pathophysiological and behavioral events that occur in children with AHT. The resultant hypoxia/ischemia suggests a potential mechanism underlying the secondary rotational acceleration-deceleration-induced brain injury in developing mice.
The central role of DNA damage and repair in CAG repeat diseases
Authors: Massey Thomas H. , Jones Lesley 
Published: January 2018

ABSTRACT
Diseases such as Huntington's disease and certain spinocerebellar ataxias are caused by the expansion of genomic cytosine-adenine-guanine (CAG) trinucleotide repeats beyond a specific threshold. These diseases are all characterised by neurological symptoms and central neurodegeneration, but our understanding of how expanded repeats drive neuronal loss is incomplete. Recent human genetic evidence implicates DNA repair pathways, especially mismatch repair, in modifying the onset and progression of CAG repeat diseases. Repair pathways might operate directly on repeat sequences by licensing or inhibiting repeat expansion in neurons. Alternatively, or in addition, because many of the genes containing pathogenic CAG repeats encode proteins that themselves have roles in the DNA damage response, it is possible that repeat expansions impair specific DNA repair pathways. DNA damage could then accrue in neurons, leading to further expansion at repeat loci, thus setting up a vicious cycle of pathology. In this review, we consider DNA damage and repair pathways in postmitotic neurons in the context of disease-causing CAG repeats. Investigating and understanding these pathways, which are clearly relevant in promoting and ameliorating disease in humans, is a research priority, as they are known to modify disease and therefore constitute prevalidated drug targets.
Desafios da gestão de riscos
Authors: Pereira Susana Carla Farias , Pereira Luís Henrique 
Published: January 2018

As cadeias de suprimentos com conexões ao redor do mundo podem trazer vantagens competitivas, mas exigem atenção redobrada dos gestores, pois são mais sujeitas a rupturas do que as que operam localmente
Assessoria genética: uma prática que estimula a eugenia?
Authors: Luque Bernal Ricardo Miguel , Buitrago Bejarano Roberto José 
Published: January 2018

Introdução: a assessoria genética é uma prática que pode enquadrar-se em quatro cenários: pré-concepcional, pré-implantação, pré-natal e pós-natal (similar o pré-concepcional). Para alguns autores este tipo de prática considera-se eugenia. O objetivo do presente artigo é expor os distintos pontos de vista, descritos na literatura, sobre a relação da assessoria genética com a eugenia. Materiais e métodos: buscaramse artigos em bases de dados acadêmicas com os termos eSH/DeCS bioética, genética médica, assessoria genética e eugenia. Incluíram-se artigos que falaram sobre eugenia ou sobre rastreio genético; excluíramse artigos com a descrição técnica de procedimentos. A seleção se realizou por título, resumo e texto completo. Resultados: selecionaram-se 57 artigos para a análise. Na assessoria pré-con- cepcional, o “princípio d bene cência procriativa” se considera que parte de posturas similares às prá- ticas eugénicas de começos do século xx. Na consulta pré-implantação, a seleção genética de embriões pode considerarse eugenia quando se usa para alterar o curso natural da procriação ou para ns não médicos. O diagnóstico prénatal, quando se vincula com o aborto por malformações congénitas, pode considerar-se eugenia negativa. Discussão: na atualidade, a eugenia abarca múltiplas de nições. Segundo a de nição escolhida, a assessoria genética pode enquadrar-se como uma prática eugénica. No entanto, o desenho de políticas de saúde e o interesse da sociedade pode in uir na autonomia dos indivíduos pode constituirse como eugenia positiva.
Reflexões sobre a necessidade da hierarquização no principialismo em bioética
Authors: Rodríguez Soriano Roberto Israel 
Published: January 2018

Introdução: neste trabalho se faz uma análise do principialismo biomédico proposto por Beauchamp e Childress, no que assumem uma postura não hierarquizada de quatro princípios (autonomia, beneficência, não maleficência e justiça). Desenvolvimento: a tese que se desenvolve é que há uma necessidade de hierarquização dos princípios em quanto a sua fundamentação ética, já que, de outro modo, dita prática pode cair em um relativismo e, assim, em uma afetação na integridade e dignidade dos pacientes. Da mesma forma, sustenta-se a tese de que o afiançamento da autonomia como princípio hierarquicamente privilegiado daria as possibilidades para gerar uma perspetiva médica não paternalista que possibilitaria, à sua vez, uma prática profissional acorde com a defesa dos direitos primários dos humanos. Conclusão: o afiançamento do princípio der autonomia permitiria gerar uma relação mais horizontal entre médico e paciente, ao reconhecer a faculdade na solução de dilemas éticos.
Are students ‘empty vessels’, or can previous experience enhance future practice?
Authors: Power Alison , Holland Laney 
Published: January 2018

In the pedagogical model used in the education of children since the 19th century ( Hill, 2015 ), the educationalist has control and decides the content and mode of delivery, with the students as ‘empty vessels’ or passive recipients of information. In contrast, adult learners are self-directing, having a repertoire of experience and are internally motivated to learn subject matter that can be applied immediately ( Knowles, 1998 ). Each student's previous experience not only makes their learning individual, but also has the potential to enrich the learning experiences of their peers and positively impact on the quality of care received by women and their babies. This article will consider the theory on how adults learn best, identifying the link between previous experience and the acquisition and application of new knowledge, and will go on to focus on the experiences of Laney Holland, a third-year student midwife, as an example of the potential for previous experiences to enhance midwives' future practice.
Obstetric emergencies: Enhancing the multidisciplinary team through simulation
Authors: Black Sophie Emma 
Published: January 2018

Background The multidisciplinary team facilitated simulation sessions that took place within a local Trust during a study day called ‘Managing the sick obstetric patient’ and during annual training of maternity staff. Aim To discuss and analyse the importance of the using the multidisciplinary team during high fidelity simulation. The aim was to review how effective the staff thought the simulation was in supporting them to enhance their skills working as a team. Methods Following the simulation session with the multidisciplinary team, a feedback sheet in the form of a questionnaire was given to all participants of the study day to evaluate its effectiveness. The themes were then derived from the data for analysis. Findings The main themes that were highlighted were: ‘improved team working’, ‘realism’, and ‘helpful refresher’. There were also three sub-themes that emerged from data collection: ‘feedback was practical and efficient’, ‘increased confidence and communication skills’, and ‘could be made more realistic’. Conclusions High fidelity simulation plays a major role in training and assessing the competence of staff. Staff valued the simulation and reported that they achieved increased confidence and communication skills as a result of participating.
National inhaler standards: Why do we need them?
Authors: Marsh Viv 
Published: January 2018

Inhaler technique is poor in many patients with respiratory conditions. Viv Marsh discusses the national inhaler standards, which aim to promote correct inhaler technique to improve patient outcomes Inhaled medication is commonly prescribed for the treatment of asthma and chronic obstructive pulmonary disease. For treatments to work effectively, inhaler technique needs to be optimal so that the prescribed medication is delivered directly to the lungs. Research has shown that many patients have sub-optimal inhaler technique and not all health professionals are able to assist people effectively. The national inhaler standards discussed in this article draw together a range of issues affecting the education and support of patients to enable them to use their inhalers correctly.
Interprofessional teamwork for multi-professional practice: Does it work in primary care?
Authors: Woods Debbie 
Published: January 2018

Aim: The purpose of this study was to understand the effects that a lack of interprofessional working can have on multi-professional practice within a primary health care setting. Design: This qualitative study explored the views and perceptions of an NHS primary care team's interprofessional working for multi-professional practice processes and whether it worked in practice. A structured questionnaire was used on 16 participants to identify themes and to highlight any future research needed in this area. Results: Themes emerging from the questionnaires included communication being the key element in interprofessional working for multi-professional practice. Fear of addressing issues with other senior members of staff was stated. It was also mentioned that some felt the NHS was not set up to encourage good working relationships, but it was also noted that the study setting was lucky to have a team that respected each other. It was felt that meetings to discuss issues affecting patient care were not provided on days when all staff were present. In addition, it was noted that there was no process in place to ensure those not present at meetings received the information and commented on it. Conclusion: Although interprofessional working for multi-professional practice is not a new phenomenon, it was clear to see from the findings of this small study that it did not always work effectively. There are many reasons why this could be, but lack of communication within the workplace was one clear issue that all participants highlighted. While many felt at ease discussing issues affecting collaborative practice with those in more senior roles, few felt that they could approach seniors without feeling that their concerns are ignored or dismissed. All participants noted that if the most senior staff show how to work effectively then the rest would follow suit.
Why Elizabeth Eisenstein might have been a technological determinist: And why, in the end, it does not really matter
Authors: Brewin Mark 
Published: January 2018

Abstract
This article makes the case for Elizabeth Eisenstein’s continuing relevance by returning to the question of technological determinism, a fraught issue in the historical study of communication generally and in discussions of Eisenstein’s work specifically. After reviewing the arguments against technological determinism, I propose that, even were we to concede that Eisenstein was a determinist, the questions raised by her study of the printing press continue to provoke interesting paths of research for historians of the early modern age. Perhaps her most important contribution has been to highlight the fact that technological artefacts can be considered social actors (or ‘agents of change’). I illustrate this point by an example from the time period: the mediated treatment of an annual sporting event, the Dover Games, which took place in the Cotswold Hills from about 1612 to 1642. Thus, while it is important to take into account the criticisms of Eisenstein’s work (and this is true whether we consider her to be a technological determinist or not), her style of historical investigation remains relevant for study into how print, and indeed other media technologies, has affected the evolution of our social environment.
A tale of three cities: Remembering ‘Betty’ Eisenstein
Authors: Mulvihill Maureen E. 
Published: January 2018

Abstract
This remembrance of distinguished print history authority, Elizabeth Lewisohn Eisenstein (1923–2016), by an established literary specialist and rare book collector, recounts intersections with Dr Eisenstein and her writings in three cities: Detroit (MI), Madison (WI), and New York City. The article includes three captioned images of Eisenstein and her published work, and closes with a brief discussion of her considerable legacy.
New approach to VFR pilot training
Authors: Vodičková Kristýna 
Published: January 2018

With an increased usage of GNSS navigation devices as one of the primary navigation means during VFR flights, it was necessary to address the issue of proper usage of such devices and to educate pilots about this new trend. Until a recent period, there was no existent comprehensive material that would enable pilots in training to get access to new evolution in navigation. Therefore, a project named CaBilAvi (Capacity Building for Aviation Stakeholders) was launched under the HORIZON 2020 framework. In this article, the author addresses the changes that were derived in VFR pilot training syllabus and pilot education materials. Furthermore, the author mentions specific activities introduced during the project, that were necessary to support the dissemination of new knowledge to the proper audience interested in general aviation.
A polynomial algorithm for packing unit squares in a hypograph of a piecewise linear function
Authors: Arslanov Marat , Amirgalieva Zhazira , Kenshimov Chingiz 
Published: January 2018

AbstractWe consider the problem of packing the maximal number of unit squares in a hypograph of a function. A polynomial time algorithm is described to solve this problem for a piecewise linear function.
Green synthesis, structural characterization, and catalytic activity of silver nanoparticles stabilized with Bridelia retusa leaf extract
Authors: Vinayagam Ramesh , Varadavenkatesan Thivaharan , Selvaraj Raja 
Published: January 2018

Abstract:An environmentally benign method to synthesize silver nanoparticles (SNPs) using the leaf extract ofBridelia retusawas developed. The UV-Vis absorption spectrum of the synthesized SNPs displayed a surface plasmon peak at 420 nm. Scanning electron microscopy (SEM) revealed the irregular shaped nanoparticles, and energy dispersive X-ray (EDX) ascertained the presence of metallic silver by showing a strong signal at 3 eV. The crystalline structure of metallic silver was confirmed by X-ray diffraction (XRD). The mean size of the SNPs was calculated as 16.21 nm. Fourier infrared (FT-IR) spectroscopic studies displayed specific bands for various functional groups and affirmed the function of reduction and stabilization of SNPs. The stability was endorsed by the zeta potential value of −18.1 mV. The results evidenced that this leaf extract-mediated synthesis method is eco-friendly, rapid, and cheap. The catalytic power of the SNPs was investigated for Rhodamine B dye degradation. The SNPs completely degraded Rhodamine B within 9 min; thus, the dye degradation process was very rapid. The pseudo-first order degradation constant was found out to be 0.1323 min−1. This paves the way for the future development of novel nano-catalysts to reduce environmental pollution.
Adapted explicit two-step peer methods
Authors: Conte Dajana , D’Ambrosio Raffaele , Moccaldi Martina , Paternoster Beatrice 
Published: January 2018

Abstract
In this paper, we present a general class of exponentially fitted two-step peer methods for the numerical integration of ordinary differential equations. The numerical scheme is constructed in order to exploit a-priori known information about the qualitative behaviour of the solution by adapting peer methods already known in literature. Examples of methods with 2 and 3 stages are provided. The effectiveness of this problem-oriented approach is shown through some numerical tests on well-known problems.
Der Leib als Umschlagstelle zwischen Kultur und Natur
Authors: Waldenfels Bernhard 
Published: January 2018

Zusammenfassung
Leibliches Verhalten, sei es Gehen, Wahrnehmen, Sprechen, Hantieren, Essen oder raumzeitliche Orientierung, entspringt diesseits von Natur und Kultur einer Lebenswelt, in der alles mehr oder weniger natürlich vorgeprägt wie künstlich geformt ist. Es vollzieht sich in zwischenleiblichem Verkehr mit Anderen. Es verkörpert sich in einer Zwischensphäre von Werkzeugen, Apparaturen, Medien und Symbolen. Es zehrt von einer natürlichen Vorgeschichte. In seiner Doppelrolle als Leibkörper bildet der Leib eine „Umschlagstelle” (Husserl) zwischen Natur und Kultur, zwischen Eigenem und Fremdem. So fungiert die Natur innerhalb der Lebenswelt, bevor sie sich in Form alltäglicher Störungen, methodisch und technisch herbeigeführter Eingriffe oder pathologischer Spaltungen absondert. Unser Leib ist nicht aus einem Guss. Reine Natur und reine Kultur sind Konstrukte der Moderne, die aus einer naturalistischen oder kulturalistischen Leibvergessenheit resultieren.
Exploring Pregnant Embodiment with Phenomenology and Butoh Dance
Authors: Stähler Tanja 
Published: January 2018

Abstract
How does pregnancy transform our embodiment? This question will be explored with the help of phenomenology and Butoh dance. Although Butoh has not yet been able to fulfil its true potential for disclosing female embodiment and particularly pregnant embodiment, it will provide us with helpful clues. In pregnancy, objects are less ready-to-hand, more out of reach - world as we know it becomes removed. The habit body vanishes away. But pregnancy is not just a loss of the ordinary: it also opens up new dimensions. One such dimension is that of being touched from within. A phenomenology of the pregnant body thus leads to a removal of world, but also reveals new dimensions of world, and it even comes to disclose the other as a new world within. It means to carry something alien, like the stone in Butoh play Child’s Breath, which can only be carried slowly, awkwardly.