bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of National Disability Insurance Scheme Plan Payments for People With Cerebral Palsy Described Using Publicly Available Data
Authors: Morgan Prue , Tang Ngoc Thien Kim , Imms Christine 
Published: October 2024

Introduction: The National Disability Insurance Scheme (NDIS) provides funding to Australians with permanent and significant disabilities to enable ‘an ordinary life’. However, we know little about the characteristics of NDIS funding in people with cerebral palsy (CP).Materials and Methods: This project explored the NDIS plan payments and support category by people with CP using publicly accessible NDIS data. A descriptive analysis was undertaken using observational statistics and variable comparisons to explore lifespan plan characteristics (core supports, capacity building and capital supports proportions) and payments between different age groupings and geographical regions.Results: 17,575 people with CP as a primary diagnosis were NDIS participants in March 2023, with plan payments of, on average, $138,000/year. Plan payments increased with age. Most funding was allocated to core supports (average $103,000 Pa) compared to capacity building (average $40,000 Pa) and capital supports (average $11,000 Pa). From 2021 to 2023, plan payments increased beyond the consumer price index. There were large differences in NDIS plan payments across metropolitan and regional locations, likely influenced by a range of personal and service availability factors unable to be identified using the publicly available data.Discussion: NDIS plan payments were larger in older people with CP. There was also low investment in the capacity building areas of employment and lifelong learning, despite this being a focus of the scheme. Unexplained differences in plan payments across regions require further research.
Tumor Integrin-Targeted Glucose Oxidase Enzyme Promotes ROS-Mediated Cell Death that Combines with Interferon Alpha Therapy for Tumor Control
Authors: Stinson Jordan A. , Sheen Allison , Lax Brianna M. , Yang Grace N. , Duhamel Lauren , Santollani Luciano , Fink Elizabeth , Palmeri Joseph R. , Wittrup Karl Dane 
Published: October 2024

Abstract
Although heightened intratumoral levels of reactive oxygen species (ROS) are typically associated with a suppressive tumor microenvironment, under certain conditions ROS contribute to tumor elimination. Treatment approaches, including some chemotherapy and radiation protocols, increase cancer cell ROS levels that influence their mechanism of cell death and subsequent recognition by the immune system. Furthermore, activated myeloid cells rapidly generate ROS upon encounter with pathogens or infected cells to eliminate disease, and recently, this effector function has been noted in cancer contexts as well. Collectively, ROS-induced cancer cell death may help initiate adaptive antitumor immune responses that could synergize with current approved immunotherapies, for improved control of solid tumors. In this work, we explore the use of glucose oxidase, an enzyme which produces hydrogen peroxide, a type of ROS, to therapeutically mimic the endogenous oxidative burst from myeloid cells to promote antigen generation within the tumor microenvironment. We engineer the enzyme to target pan-tumor-expressed integrins both as a tumor-agnostic therapeutic approach and as a strategy to prolong local enzyme activity following intratumoral administration. We found the targeted enzyme potently induced cancer cell death and enhanced cross-presentation by dendritic cells in vitro and further combined with interferon alpha for long-term tumor control in murine MC38 tumors in vivo. Optimizing the single-dose administration of this enzyme overcomes limitations with immunogenicity noted for other prooxidant enzyme approaches. Overall, our results suggest ROS-induced cell death can be harnessed for tumor control and highlight the potential use of designed enzyme therapies alongside immunotherapy against cancer.
Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells
Authors: Gamma Jay M. , Liu Qiang , Beauchamp Erwan , Iyer Aishwarya , Yap Megan C. , Zak Zoulika , Ekstrom Cassidy , Pain Rony , Kostiuk Morris A. , Mackey John R. , Brandwein Joseph , Wang Jean C.Y. , Berthiaume Luc G. 
Published: October 2024

Abstract
Acute myeloid leukemia (AML) is a hematologic malignancy with limited treatment options and a high likelihood of recurrence after chemotherapy. We studied N-myristoylation, the myristate modification of proteins linked to survival signaling and metabolism, as a potential therapeutic target for AML. N-myristoylation is catalyzed by two N-myristoyltransferases (NMT), NMT1 and NMT2, with varying expressions in AML cell lines and patient samples. We identified NMT2 expression as a marker for survival of patients with AML, and low NMT2 expression was associated with poor outcomes. We used the first-in-class pan-NMT inhibitor, zelenirstat, to investigate the role of N-myristoylation in AML. Zelenirstat effectively inhibits myristoylation in AML cell lines and patient samples, leading to degradation of Src family kinases, induction of endoplasmic reticulum stress, apoptosis, and cell death. Zelenirstat was well tolerated in vivo and reduced the leukemic burden in an ectopic AML cell line and in multiple orthotopic AML patient-derived xenograft models. The leukemia stem cell–enriched fractions of the hierarchical OCI-AML22 model were highly sensitive to myristoylation inhibition. Zelenirstat also impairs mitochondrial complex I and oxidative phosphorylation, which are critical for leukemia stem cell survival. These findings suggest that targeting N-myristoylation with zelenirstat represents a novel therapeutic approach for AML, with promise in patients with currently poor outcomes.
Sparse-Coding Variational Autoencoders
Authors: Geadah Victor , Barello Gabriel , Greenidge Daniel , Charles Adam S. , Pillow Jonathan W. 
Published: October 2024

Abstract
The sparse coding model posits that the visual system has evolved to efficiently code natural stimuli using a sparse set of features from an overcomplete dictionary. The original sparse coding model suffered from two key limitations; however: (1) computing the neural response to an image patch required minimizing a nonlinear objective function via recurrent dynamics and (2) fitting relied on approximate inference methods that ignored uncertainty. Although subsequent work has developed several methods to overcome these obstacles, we propose a novel solution inspired by the variational autoencoder (VAE) framework. We introduce the sparse coding variational autoencoder (SVAE), which augments the sparse coding model with a probabilistic recognition model parameterized by a deep neural network. This recognition model provides a neurally plausible feedforward implementation for the mapping from image patches to neural activities and enables a principled method for fitting the sparse coding model to data via maximization of the evidence lower bound (ELBO). The SVAE differs from standard VAEs in three key respects: the latent representation is overcomplete (there are more latent dimensions than image pixels), the prior is sparse or heavy-tailed instead of gaussian, and the decoder network is a linear projection instead of a deep network. We fit the SVAE to natural image data under different assumed prior distributions and show that it obtains higher test performance than previous fitting methods. Finally, we examine the response properties of the recognition network and show that it captures important nonlinear properties of neurons in the early visual pathway.
Deadlocked International Institutions: Implications for Negotiated Conflict Management
Authors: Terrence Hopmann P. 
Published: October 2024

Abstract
This article argues that the international institutions in which negotiations have often taken place have been challenged by increased conflict among member states in the early 21st century. Multilateral international institutions function best when common interests are viewed as paramount by the state parties, because they allow the state parties to negotiate structures and processes that serve their shared interests and values. The paper analyzes the difficulties in managing international conflicts in the UN, osce, nato, and EU since 2000 due in part to the inability to achieve consensus within fractured and stalemated institutions. These problems have increasingly limited the role of these institutions in managing some of the most dangerous global conflicts, including on arms control and disarmament and managing the Russian war in Ukraine.
Criminal Legal Steps to Stop the Irregular Migration in Hungary
Authors: Sántha Ferenc , Bartkó Róbert 
Published: October 2024

Abstract
From 2015, migratory pressures put a heavy burden on EU countries. In 2015, Hungary took a new approach by building a border fence and creating criminal legal rules to protect it. This study aims to assess these measures in the EU sphere. Our research was based on EU (frontex) and national (Prosecutor General’s Office information) data and assessed the Hungarian solution in the light of the migration policy of other Member States located along the main migratory routes. The data show: (1) the criminal law has no substantive effect, and (2) the law enforcement tools are effective. Moreover, the domestic data also show that Hungary is not consistent in its policy and has preferred law enforcement tools to criminal legal tools in the past few years, which violates the basic principles of criminal law: the principle of legality and the principle of ultima ratio.
The Right to a Public Hearing in Criminal Cases in the Digital Age
Authors: Lach Arkadiusz 
Published: October 2024

Summary
The author analyses the right to a public hearing in criminal cases in the light of the development of communication technology, the media, and the digitalization of courts. After a presentation of the current Strasburg standards he shows the competing values and the need for balance. He presents the possible solutions of preserving the right in relation to traditional hearings, hybrid hearings, virtual hearings, and online courts. It is argued that the development of different forms of remote hearings changes the perception and implementation of the right to a public hearing and that developments in technology call for limitations on the public character of hearings, rather than for increasing publicity. It was also observed that the Strasburg jurisprudence not only identifies the negative obligations of parties concerning the right, but also requires them to take some positive actions.
Jurisdiction in Criminal Law in the EU – Revised
Authors: Demenko Anna 
Published: October 2024

Abstract
In this paper, I outline a proposal for a revised approach to jurisdiction over criminal matters in the European Union, concerning real-world situations. The analysis is rooted in two fundamental premises – the condition of foreseeability of the relevant norms, and the possibility of separating substantial and procedural criminal laws. From this perspective, I argue for a reduction of the jurisdictional nexuses applicable in the context of interactions between Member States. Considering the fundamentals of criminal law and the aim of the Union to create one area of freedom, security and justice, a multiplication of various links is superfluous. A reduction is not only possible and justified to adequately protect the interests of the states and individuals but would also provide a suitable tool for mitigating redundant conflicts of jurisdiction.
The Language of Grief: The Role of Conceptual Metaphors in Family Tributes of Ghanaian Funeral Ceremonies
Authors: Afreh Esther Serwaah , Ofosu Daniel Dwamena 
Published: October 2024

Abstract
This paper investigates the role of conceptual metaphors in the expression of grief by bereaved families during Ghanaian funeral ceremonies. Grief is a universal and inevitable response to loss or the anticipation of it, yet its manifestation varies among different cultures and individuals. In Ghanaian funeral ceremonies, tributes hold significant importance as they provide a platform for family members to publicly convey their emotions and memories associated with the deceased. Tribute texts gathered from twenty funeral brochures were analysed using the Pragglejaz Group’s Metaphor Identification Procedure (mip). The analysis revealed the utilisation of twelve distinct conceptual metaphors related to life and death, marriage, and memories and emotions. Two image metaphors about the deceased were also identified. The analysis reveals that families employ conceptual and image metaphors – to offer consolation, provide encouragement, express appreciation for the deceased’s life, engage in reminiscence, honour and celebrate the departed souls.
The Semantics of Happiness and Joy in the Italian Language
Authors: Sotgiu Igor 
Published: October 2024

Abstract
A number of contemporary researchers have proposed considering happiness and joy as distinct phenomena and theoretical constructs. However, there is as yet insufficient information regarding whether the theoretical and empirical arguments for distinguishing happiness from joy also apply to folk representations of these concepts. This work presents two studies in which Italian speakers performed a free-listing task asking them to list words semantically equivalent to the Italian words felicità (happiness) (Study 1) and gioia (joy) (Study 2). A comparison between the two studies revealed that the Italian concepts of happiness and joy had 49 lexical items in common, 32 of which related to emotions. Interestingly, 11 of the latter ranked in the top 10 cognitive salience indexes obtained from both Study 1 and Study 2. It is argued that the semantic similarities between the two words examined – felicità and gioia – should not overshadow the meaning nuances distinguishing them.
19. Performing Iannis Xenakis’s Polyrhythms
Authors: Talgam Imri 
Published: October 2024

Xenakis often uses complex superimposed polyrhythms that are uniquely challenging for performers to realize, especially in solo and chamber works. Faced with overwhelming rhythmic complexity, performers must choose a strategy to navigate the score, often resulting in informal compromises and approximations. As an alternative, in this chapter, I propose a methodological approach to performance of rhythmic complexity using re-notation informed by theories of metric perception. Using examples from Mists, À l’île de Gorée, and Dikhthas, I identify three classes of rhythmic textures: irregular a-metrical rhythms, isochronous polyrhythms, and phase-shifted polyrhythms. While Xenakis’s notation clearly conveys these distinct ideas, it does not facilitate accurate realization in performance, which diminishes the polyphonic quality of these passages. My methodology proceeds in several stages: a) Analysis of the primary cues for grouping and possible metric interpretations of each rhythmic texture using the theory proposed by London; b) using the notion of context-sensitive constraints on metric perception (I propose a quantization strategy to reduce the complexity of the rhythm while preserving the macro characteristics; c) proposal of several possible re-notations, depending on the grouping cues or pulse layers that are taken as the tactus in the passage, while relegating other layers to ana-metrical status.
Since multiple versions may be beneficial in representing different aspect of the music, I consider their advantages from both performers’ and listeners’ perspectives; d) finally, I examine the dynamics of listening and synchronization between multiple players in realizing rhythmically complex passages, in which players create a metric interpretation collaboratively.
32. Somax2 and Reinterpreting Iannis Xenakis
Authors: Malt Mikhail , Sluchin Benny 
Published: October 2024

In the French leg of the Meta-Xenakis marathon global conference, we presented a Computer Aided Improvisation Performance based on Xenakis’s Keren for trombone. This was possible with the SOMAX 2 environment, developed by the Representations Musicales Research Team, at Ircam, a multi-agent interactive system performing live machine co-improvisation with musicians, based on machine-listening and generative units. Here we briefly present SOMAX 2, opening the path to a future detailed explanation of the musical and aesthetic implications concerning its use.
39. The Process of Creating a Computational System
Authors: Solís Hugo , Bernal Mizky , Jiménez Diego , Leonardini Guillermo , Pérez Eunice 
Published: October 2024

This chapter describes the process of generation and collaboration of a computational system of audiovisual composition modeled in three dimensions based on three main points: the tradition of the Xenakis's UPIC environment, the authors' own ideas regarding the sonic reinterpretation of flock behavior, and the use of the Three.js JavaScript library. The system has two sound procedures: the sonification of the spatial location of the agents in relation to the emergent phenomenon (Flock Behavior), and the reinterpretation of such positions in relative coordinates by means of planes.
43. Meta-Xenakis Concert at Suntory Hall, Tokyo
Authors: Kato Kuniko 
Published: October 2024

As a part of the Meta-Xenakis centennial celebration of the life and work of Iannis Xenakis, Kuniko Kato, percussionist, and ARTSWORKS presented this concert at Suntory Hall, Tokyo, Japan on Friday, November 11, 2022, including Xenakis’s two solo percussion works [(Rebonds A. B. (1987-89) and Psappha (1975)], an ‘installation–improvisation’, and a new spatialization of Hibiki-Hana-Ma. After the performance, a post-concert talk took place with music critic Tadashi Yamanouch, composer/musicologist Mikako Mizuno and Kuniko Kato.
The concert was co-sponsored by Meta Xenakis Consortium, Centre Iannis Xenakis, Japan Society for Contemporary Music, The Embassy of Greece in Japan.
The concert footage was filmed by TV MAN UNION.
51. Iannis Xenakis, 1922–2001
Authors: Sluchin Benny 
Published: October 2024

The centenary of Xenakis’s birth caught me by surprise. I have many items concerning him, archived for more than forty years already, and it became obvious for me to highlight them through a particular discographic tribute. Iannis Xenakis 1922-2001: Texts, Essays, and Music (Utperformance, 2022) contains previously unreleased studio and live recordings accompanied by various texts, many of which are also unreleased to date.
The texts particularly explore the production of Xenakis for Brass: Eonta (1964), Linaia-Agon (1972), N’Shima (1975), Keren (1986), and Zythos (1997). Personal remarks included in these texts constitute an original contribution. Finally, a kabbalistic analysis of two Hebrew titles of the works included as well as a text commenting on a work by Freud conclude this tribute. A path that recalls the richness and variety of the composer’s theories.
This project is available in two forms: a) CD with a 48-page booklet in French (English version is available on the producer’s website), b) Book/CD of 116 pages in French.
Poster 112: Toxicity of Chlorhexidine and Povidone-Iodine to Rotator Cuff Tendon
Authors: Moslehyazdi Maziar , Bielajew Benjamin , Hu Jerry , Athanasiou Kyriacos , Johnston Tyler , Wang Dean 
Published: October 2024

Objectives: Antimicrobial wound lavages containing chlorhexidine gluconate (CHG) or povidone-iodine (PI) are commonly used to prevent periprosthetic infection during shoulder arthroplasty. However, the potential toxicity of these solutions to the native surrounding rotator cuff tendon is not well understood. In total shoulder arthroplasty, the rotator cuff tendon is often concomitantly repaired, and any toxic effects from antimicrobial wound lavage during surgery may be detrimental to postoperative rotator cuff tendon healing. The purpose of this study was to determine the in vitro effects of a 1-minute CHG exposure and a 3-minute 0.35% PI exposure on the viability and biochemical content of rotator cuff tendon. Methods: Infraspinatus tendons (n=6 per group) were isolated from shoulders of Nubian goats (n=3; 2 female and 1 male). Tendons were submerged in Irrisept (0.05% CHG in sterile water) for 1 minute or 0.35% Betadine (PI) for 3 minutes per manufacturer guidelines, followed by phosphate-buffered saline wash and culture in tissue culture medium. Control tendon specimens were similarly exposed to tissue culture medium, followed by phosphate-buffered saline wash and culture in tissue culture medium. After seven days of culture, isolates from both the tendinous and enthesis portions of the rotator cuff were analyzed for viability, collagen content (hydroxyproline assay), and glycosaminoglycan (GAG) content (dimethylmethylene blue assay). Statistical analyses were performed via one-way ANOVA with post hoc Tukey’s test. Results: Within the tendinous portion of the rotator cuff, CHG-treated specimens demonstrated a decrease in mean tenocyte viability compared to controls (p=0.045) (Fig.1). While PI-treated specimens exhibited lower mean viability compared to controls, this difference was not statistically significant. Within the enthesis portion of the rotator cuff, tenocyte viability decreased in both CHG- and PI-treated groups; however, these decreases were not statistically significant (Fig. 2). There were no significant differences in mean collagen content/wet weight or GAG/wet weight among groups within the tendinous and enthesis portion of the rotator cuff (Fig. 3). Conclusions: Due to the potential catastrophic consequences associated with periprosthetic infection, CHG and PI antimicrobial lavages are commonly used to reduce the risk of periprosthetic infection during shoulder arthroplasty. However, in this study, brief 0.05% CHG and 0.35% PI exposures to rotator cuff tendon resulted in lower tenocyte viability 7 days after treatment. These results are consistent with the toxicity reported with exposure of CHG and PI to other musculoskeletal tissues, including articular cartilage. The toxicity of antimicrobial irrigation to the surrounding native rotator cuff tendon may be detrimental to the postoperative healing of concomitant rotator cuff repair in the setting of shoulder arthroplasty.