bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life with long-term retention of the PROSthesis of Antibiotic Loaded Acrylic Cement system following infection resolution in low demand patients
Authors: Beaupre Lauren A , Stampe Kyle , Masson Edward , O’Connor Gregory , Clark Marcia , Joffe A Mark , Boychuk Lesia R , Lavoie Guy 
Published: June 2017

Background: The study purpose was to (1) evaluate health-related quality of life (HRQL) with the PROSthesis of Antibiotic Loaded Acrylic Cement (PROSTALAC) in situ for infected total hip arthroplasty (THA), (2) determine infection resolution, and (3) compare subjects who underwent second stage surgery with those who retained the PROSTALAC on a longer term basis. Methods: Demographics, physical demand level, and comorbidities were recorded prospectively in 29 subjects followed to at least 24 months after initial PROSTALAC insertion. HRQL was evaluated using the Western Ontario McMaster Osteoarthritis Index (WOMAC) and RAND 36-Item Health Survey. Infection resolution was determined using a pre-specified clinical definition. Results: Twenty-five of 29 (86%) subjects’ infections resolved. Three subjects died, of whom two had resolved infections. For survivors, 22/26 (85%) completed HRQL evaluations. After PROSTALAC insertion, pain and function improved within 3–6 months and was retained at 24 months. Of those followed to 24 months, 7/22 (32%) subjects underwent second stage surgery. They were higher physical demand subjects ( p = 0.03) than those not undergoing second stage surgery. We found no difference in WOMAC scores at 24 months between those who underwent second stage surgery and those who retained the PROSTALAC ( p > 0.32). Discussion: The PROSTALAC system for THA appears to allow acceptable HRQL while in situ for at least 2 years in low physical demand patients. Subjects with higher physical demand levels are more likely to undergo second stage surgery. Conclusion: Further evaluation is required to determine whether longer term PROSTALAC retention may be appropriate for specific patient groups.
Acceptability of Chairside Screening for Racial/Ethnic Minority Older Adults: A Qualitative Study
Authors: Greenblatt A.P. , Estrada I. , Schrimshaw E.W. , Metcalf S.S. , Kunzel C. , Northridge M.E. 
Published: June 2017

An aging and more racially and ethnically diverse population, coupled with changes in the health care policy environment, is demanding that the dental profession both redirect and expand its focus. Challenges include providing comprehensive care for patients with complicated medical needs while improving access to care for underserved groups. The purpose of this study is to examine the acceptability of screening for hypertension and diabetes in the dental setting for African American, Puerto Rican, and Dominican older adults who attend senior centers in northern Manhattan, New York City. Focus groups were conducted with 194 racial/ethnic minority men and women aged 50 y and older living in northern Manhattan who participated in 1 of 24 focus group sessions about improving oral health for older adults. All groups were digitally audio-recorded and transcribed for analysis. Groups that were conducted in Spanish were transcribed first in Spanish and then translated into English. Analysis of the transcripts was conducted using thematic content analysis. Five themes were manifest in the data regarding the willingness of racial/ethnic minority older adults to receive hypertension and diabetes screening as part of routine dental visits: 1) chairside screening is acceptable, 2) screening is routine for older adults, 3) the interrelationship between oral and general health is appreciated, 4) chairside screening has perceived benefits, and 5) chairside screening may reduce dental anxiety. Reservations centered on 4 major themes: 1) dental fear may limit the acceptability of chairside screening, 2) there is a perceived lack of need for dental care and chairside screening, 3) screening is available elsewhere, and 4) mistrust of dental providers as primary care providers. This study provides novel evidence of the acceptability of screening for hypertension and diabetes in the dental setting among urban racial/ethnic minority senior center attendees. Knowledge Transfer Statement: The results of this study may be used by oral health providers when deciding whether to conduct chairside screening for medical conditions such as hypertension and diabetes that could affect, or be affected by, the oral health of their patients. Patient experiences of care—along with clinical outcomes, avoidable hospital admissions, equity of services, and costs—are important outcomes to consider in meeting the needs of an aging and racially and ethnically diverse US population.
The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload–mediated hepatic inflammation
Authors: Li Min , Tang Yuxiao , Wu Lusha , Mo Fengfeng , Wang Xin , Li Hongxia , Qi Ruirui , Zhang Hongwei , Srivastava Arun , Ling Chen 
Published: June 2017

Abstract
Hepatic iron overload (IO) is a major complication of transfusional therapy. It was generally thought that IO triggers substantial inflammatory responses by producing reactive oxygen species in hepatic macrophages. Recently, a decrease in microRNA-122 (miR-122) expression was observed in a genetic knockout (Hfe−/−) mouse model of IO. Because hepatocyte-enriched miR-122 is a key regulator of multiple hepatic pathways, including inflammation, it is of interest whether hepatocyte directly contributes to IO-mediated hepatic inflammation. Here, we report that IO induced similar inflammatory responses in human primary hepatocytes and Thp-1–derived macrophages. In the mouse liver, IO resulted in altered expression of not only inflammatory genes but also &gt;230 genes that are known targets of miR-122. In addition, both iron-dextran injection and a 3% carbonyl iron–containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4α expression and its downstream target, miR-122. Interestingly, the same signaling pathway was changed in macrophage-deficient mice, suggesting that macrophages are not the only target of IO. Most importantly, hepatocyte-specific overexpression of miR-122 rescued IO-mediated hepatic inflammation. Our findings indicate the direct involvement of hepatocytes in IO-induced hepatic inflammation and are informative for developing new molecular targets and preventative therapies for patients with major hemoglobinopathy.
Clinical and nutritional factors associated with dialysis initiation and mortality in chronic kidney disease
Authors: de Oliveira Mariana Cassani , Tapias Thaysse Montebello , de Góes Cassiana Regina , Martin Luis Cuadrado , Balbi André Luís , Bufarah Marina Nogueira Berbel , Vannini Francieli Cristina Delatim 
Published: June 2017

Abstract
Background
Chronic kidney disease is worldwide recognized as a public health problem due to high rates of morbidity and mortality. At the end stage of the disease, which the glomerular filtration rate is equal or less than 15 ml/min/1.73 m2, dialysis initiation is usually indicated. In the absence of a consensus on the best time of beginning, the aim of this study was to identify clinical and nutritional factors associated with clinical outcomes with the start of dialysis and death.

Methods
In a prospective cohort of 82 patients, clinical (underlying renal disease, renal survival time, systolic and diastolic blood pressure, estimated glomerular filtration rate) and nutritional data (protein intake, anthropometry, bioelectrical impedance test, and strength handgrip) were collected. We used mean and standard deviation or median and association of the variables with the outcome entry into dialysis or death, and a Cox regression model was applied. Statistical significance was p < 0.05.

Results
Fifty-eight patients were included in group 1—G1 (without dialysis)—and 24 patients in group 2—G2 (dialysis). The groups were different in blood urea nitrogen (p = <0.001), serum creatinine (p = 0.003), estimated glomerular filtration rate (p = 0.002), and serum phosphorus (p = 0.002). After multivariate analysis, only serum albumin (HR 0.342, p = 0.004) and glomerular filtration rate (HR 0.001, p = 0.001) were associated with entry into dialysis and death.

Conclusions
We concluded that lower levels of serum albumin and glomerular filtration rate values are associated with entry into dialysis or death.
Impact of Recurrence and Salvage Surgery on Survival After Multidisciplinary Treatment of Rectal Cancer
Authors: Ikoma Naruhiko , You Y. Nancy , Bednarski Brian K. , Rodriguez-Bigas Miguel A. , Eng Cathy , Das Prajnan , Kopetz Scott , Messick Craig , Skibber John M. , Chang George J. 
Published: June 2017

Purpose After preoperative chemoradiotherapy followed by total mesorectal excision for locally advanced rectal cancer, patients who experience local or systemic relapse of disease may be eligible for curative salvage surgery, but the benefit of this surgery has not been fully investigated. The purpose of this study was to characterize recurrence patterns and investigate the impact of salvage surgery on survival in patients with rectal cancer after receiving multidisciplinary treatment. Patients and Methods Patients with locally advanced (cT3-4 or cN+) rectal cancer who were treated with preoperative chemoradiotherapy followed by total mesorectal excision at our institution during 1993 to 2008 were identified. We examined patterns of recurrence location, time to recurrence, treatment factors, and survival. Results A total of 735 patients were included. Tumors were mostly midrectal to lower rectal cancer, with a median distance from the anal verge of 5.0 cm. The most common recurrence site was the lung followed by the liver. Median time to recurrence was shorter in liver-only recurrence (11.2 months) than in lung-only recurrence (18.2 months) or locoregional-only recurrence (24.7 months; P = .001). Salvage surgery was performed in 57% of patients with single-site recurrence and was associated with longer survival after recurrence in patients with lung-only and liver-only recurrence ( P < .001) but not in those with locoregional-only recurrence ( P = .353). Conclusion We found a predilection for lung recurrence in patients with rectal cancer after multidisciplinary treatment. Salvage surgery was associated with prolonged survival in patients with lung-only and liver-only recurrence, but not in those with locoregional recurrence, which demonstrates a need for careful consideration of the indications for resection.
The effect of sterol structure upon clathrin-mediated and clathrin-independent endocytosis
Authors: Kim Ji Hyun , Singh Ashutosh , Del Poeta Maurizio , Brown Deborah A. , London Erwin 
Published: June 2017

ABSTRACT
Ordered lipid domains (rafts) in plasma membranes have been hypothesized to participate in endocytosis based on inhibition of endocytosis by removal or sequestration of cholesterol. To more carefully investigate the role of the sterol in endocytosis, we used a substitution strategy to replace cholesterol with sterols that show various raft-forming abilities and chemical structures. Both clathrin-mediated endocytosis of transferrin and clathrin-independent endocytosis of clustered placental alkaline phosphatase were measured. A subset of sterols reversibly inhibited both clathrin-dependent and clathrin-independent endocytosis. The ability of a sterol to support lipid raft formation was necessary for endocytosis. However, it was not sufficient, because a sterol lacking a 3β-OH group did not support endocytosis even though it had the ability to support ordered domain formation. Double bonds in the sterol rings and an aliphatic tail structure identical to that of cholesterol were neither necessary nor sufficient to support endocytosis. This study shows that substitution using a large number of sterols can define the role of sterol structure in cellular functions. Hypotheses for how sterol structure can similarly alter clathrin-dependent and clathrin-independent endocytosis are discussed.
Applying inventory classification to a large inventory management system
Authors: May Benjamin Isaac , Atkinson Michael P. , Ferrer Geraldo 
Published: June 2017

Inventory classification aims to ensure that business-driving inventory items are efficiently managed in spite of constrained resources. There are numerous single- and multiple-criteria approaches to it. Our objective is to improve resource allocation to focus on items that can lead to high equipment availability. This concern is typical of many service industries such as military logistics, airlines, amusement parks and public works. Our study tests several inventory prioritization techniques and finds that a modified multi-criterion weighted non-linear optimization (WNO) technique is a powerful approach for classifying inventory, outperforming traditional techniques of inventory prioritization such as ABC analysis in a variety of performance objectives.
Should Intangible Investments Be Reported Separately or Commingled with Operating Expenses? New Evidence
Authors: Enache Luminita , Srivastava Anup 
Published: June 2017

We propose a new method to estimate intangible investment outlays, other than expenditures on advertising and research and development, that are reported on a commingled basis with operating expenses in the selling, general, and administrative category of expenses. These outlays, aimed at improving organizational knowledge and capabilities, are the largest category of intangible investments and the fastest-growing category of operating investments. They affect future firm performance and risk. Predictability of future earnings and stock returns improves when these outlays are distinguished from operating expenses. Thus, benefits could accrue from reporting them separately. The SAS program to divide MainSG&A into investment and consumption portions is available at https://doi.org/10.1287/mnsc.2017.2769 . This paper was accepted by Suraj Srinivasan, accounting.
Positional Anthropometric and Performance Profile of Elite Gaelic Football Players
Authors: Shovlin Aidan , Roe Mark , Malone Shane , Collins Kieran 
Published: June 2017

Abstract
Shovlin, A, Roe, M, Malone, S, and Collins, K. Positional anthropometric and performance profile of elite gaelic football players. J Strength Cond Res 32(8): 2356–2362, 2018—The aim of the current investigation was to evaluate the variation in the anthropometric and performance characteristics of elite Gaelic football players with respect to position. One hundred forty-eight elite Gaelic footballers underwent anthropometric (height, body mass, sum of 7 skinfolds, and % adipose tissue) and performance (counter movement jump [CMJ] height, CMJ peak power, CMJ relative peak power, squat jump [SJ] height, SJ peak power, SJ relative peak power, 5-, 10-, and 20-m sprint times, and Yo-Yo Intermittent Recovery Test Level 2 [Yo-YoIRT2]) during “the early in-season” phase. Data were split into 5 positional groups (full back, half back, midfield, half forward, and full forward). Higher adipose tissue percentage estimate was observed in full forwards when compared with the half backs (p = 0.001), midfielders (p = 0.035), and half forwards (p = 0.021). Full forwards had significantly greater SJ (p = 0.036) and CMJ (p = 0.013) when compared with the midfielders with no other positional differences observed. No significant variation in sprint times was observed across the positions. When Yo-YoIRT2 was considered, full forwards and full backs completed significantly lower distances compared with the middle 3 positional lines of half backs, midfielders, and half forwards (p = 0.00). The current study is the first to provide normative data for anthropometric and performance values of elite Gaelic football players which in turn can be used by coaches to generate appropriate training regimes to maximize position-specific preparation for competitive match-play.
Descrição de casos de Enterobactérias Produtoras de Carbapenemases subtipos Oxa-48 e NDM em hospital público de Porto Alegre
Authors: Scherer Juliane De Souza , Calvetti Ricardo Andrade 
Published: June 2017

Justificativa: A multirresistência bacteriana vem preocupando gestores e profissionais de saúde em esfera global. Neste contexto, a resistência aos carbapenêmicos em enterobactérias é particularmente preocupante em função de sua alta mortalidade (de 40 a 50% em 30 dias) e pelas reduzidas opções de tratamento. Entre as carbapenemases, os subtipos KPC (Klebsiella pneumoniae carbapenemase), NDM (New Delhi Metallobetalactamase) e OXA (Oxa-carbapenemase) são encontrados no estado. Objetivo: descrever os casos de enterobatérias produtoras de carbapenemase (EPC) subtipos OXA e NDM em um hospital público de Porto Alegre. Método: Trata-se de pesquisa transversal, utilizando o banco de dados da Comissão de Controle de Infecção Hospitalar do hospital em estudo. A coleta de dados ocorreu após aprovação do Comitê de Ética em Pesquisa no mês de abril de 2015. A amostra englobou os casos confirmados de EPC subtipos OXA e NDM de janeiro a dezembro de 2013. Resultados: Foram identificados 34 casos de EPC, sendo 22 casos confirmados do subtipo OXA-48 e 12 casos do subtipo NDM. Entre os pacientes portadores do subtipo OXA-48, os homens totalizaram 77,3% e a colonização superou em muito a infecção 81,2%; a mortalidade atingiu 54,5% dos casos, sendo que o microrganismo mais prevalente foi a Klebsiella pneumoniae (45,5%). Os homens somaram 58,4% dos casos de NDM, com predominância de colonizações 83,3% em isolados de Enterobacter cloacae, cuja mortalidade contabilizou 58,3%. Conclusões: A elevada mortalidade e a prevalência de colonizações foram relevantes nesta pesquisa. Portanto, a detecção precoce destes mecanismos de resistência pode contribuir para conter sua disseminação.
Descritores: Resistência microbiana a medicamentos; Controle de infecções; Enterobacteriaceae
OFICINA PEDAGÓGICA NA CONSTRUÇÃO DE CONHECIMENTOS SOBRE ARBOVIROSES
Authors: Mascarenhas Priscila Meira , Lopes Valéria Marques , Silva Maílla Dos Santos , Da Silva Geslaney Reis , Duarte Ana Cristina Santos , Boery Rita Narriman Silva de Oliveira 
Published: June 2017

<p>Objetivo: descrever o uso da <strong>oficina pedagógica como um </strong>espaço de construção, reflexão e problematização da realidade. Método: Relato de experiência. Foi realizada uma oficina pedagógica com 10 estudantes do curso de Licenciatura em Ciências Biológicas de uma Universidade Estadual do Sudoeste da Bahia – Brasil, em maio de 2016, sobre a temática dengue, zika e chikungunya, com a aplicação de um pré-teste e de um pós-teste. Resultados: O grupo possuía conhecimentos acerca do tema, demonstrando não ser algo novo devido à divulgação por meios de comunicação. Observou-se a necessidade de esclarecimentos quanto à diferenciação de sinais e sintomas, e reforço em algumas medidas preventivas, o que foi abordado no decorrer da intervenção. Conclusão: A oficina contribuiu para a propagação de conhecimento sobre a temática, permitiu fomentar a associação teoria-prática a partir de uma realidade vivida que precisa ser trabalhada, inquietando os participantes a serem atores sociais nesse processo.</p><p> </p><p><strong>Descritores: </strong>Dengue; Zika Vírus; Vírus Chikungunya; Conhecimento. </p>
As campanhas eleitorais do plebiscito no Pará, em 2011 e o jogo político de construção de imagens
Authors: De Aquino Evelyn Cristina Ferreira 
Published: June 2017

<p><strong>RESUMO</strong></p><p>O artigo enfoca os modelos de organização e produção de campanhas e políticas no Brasil, com destaque para o papel da televisão e, mais especificamente, do horário gratuito de propaganda eleitoral. A análise se estende a um objeto inédito na história político-democrática do país: a campanha do plebiscito no Pará, em 2011, sobre a criação ou não dos estados do Carajás e do Tapajós, sua composição e suas estratégias de produção. O método analítico utilizou o conceito de política de imagem de Wilson Gomes (2004). Identificou-se uma homogeneização das campanhas que tratavam de diferentes regiões, o direcionamento das estratégias à população da capital do Pará, Belém, e o "jogo" político de construção e desconstrução de imagens dos sujeitos que estiveram à frente das campanhas do plebiscito.</p><p> </p><p><strong>ABSTRACT</strong></p><p>The article focuses on organizational models and production of political campaigns in Brazil emphasizing the role of television and, more specifically, the free time for political propaganda. A unique object in the political and democratic history of the country is analyzed: composition and production strategies of the campaign for a plebiscite in Pará, in 2011, about creating or not the states of Carajás and Tapajós. The analytical method used the concept of image policy of Wilson Gomes (2004). One could identify a homogenization of campaigns that dealt with different regions, the establishment of strategies targeting the population from the capital city of Pará, Belém, and the political "game" of image construction and deconstruction of political actors that conducted the campaign.</p>
Estratégias de retórica e enquadramento na cobertura do segundo mandato de Dilma Rousseff pelas revistas semanais brasileiras
Authors: Da Silva Marcos Paulo , Jeronymo Raquel De Souza 
Published: June 2017

<p><strong>RESUMO</strong></p><p>Este texto volta-se à matriz de referências da framing analisys para estudar o modo como duas das maiores revistas semanais brasileiras – Veja e IstoÉ – valem-se de estratégias retóricas para estabelecerem enquadramentos noticiosos semelhantes na cobertura do primeiro ano do segundo mandato da presidenta Dilma Rousseff. Como recorte empírico, o trabalho debruça-se sobre as edições dos meses de janeiro e dezembro de 2015, período marcado por uma profunda crise política envolvendo o Governo Federal brasileiro. Conclui-se que o tratamento realizado pelas revistas semanais estudadas, sobretudo em seus processos de seleção de fontes, hierarquização de informações e utilização de figuras retóricas, aproxima-se de um modelo de enquadramento noticioso hegemônico nos termos trabalhados por Gitlin (2003), Porto (2002), Sigal (1974) e Soley (1992), tais como: a simplificação, a dramatização, o silenciamento de atores políticos e a constituição de um padrão hegemônico das fontes.</p><p> </p><p><strong>ABSTRACT</strong></p>The article uses the framing analysis references in order to study how two of the largest Brazilian weekly magazines – Veja and IstoÉ – employ rhetorical strategies to similarly frame their news coverage of the first year of the second term of President Dilma Rousseff. As empirical frame, the study focuses on the issues of January and December, 2015, a period marked by a deep political crisis involving the Brazilian federal government. It can be concluded that the approach of the two weekly magazines, especially in their sources selection processes, hierarchy of information and use of rhetorical figures, resembles a hegemonic news framing model such as those employed by Gitlin (2003), Porto (2002), Sigal (1974) and Soley (1992), such as: simplification, dramatization, muting of political actors and construction of a hegemonic pattern of sources.