bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solitär fibröser Tumor in einem follikulären Adenom der Schilddrüse
Authors: Theurer Sarah , Schimmack Simon , Baba Hideo A. 
Published: September 2024

ZusammenfassungBei einer 28-jährigen Patientin lag ein größenprogredienter Knoten der Schilddrüse vor, der aufgrund einer lokalen Beschwerdesymptomatik operativ entfernt wurde. Histologisch konnte ein solitär fibröser Tumor (SFT) in einem Schilddrüsenadenom diagnostiziert werden. Molekulargenetisch lag eine spezifische NAB2-STAT6-Fusion vor.Solitär Fibröse Tumoren kommen selten in der Schilddrüse vor und sind dort sowohl als Primär- wie auch als Sekundärmanifestation beschrieben. Dabei erfolgen die Diagnostik, die Prognoseabschätzung und die Therapieentscheidung analog zu SFT anderer Lokalisation.
Simulating the aftermath of Northern European Enclosure Dam (NEED) break and flooding of European coast
Authors: Maczuga Paweł , Łoś Marcin , Valseth Eirik , Serra Albert Oliver , Siwik Leszek , Celaya Elisabede Alberdi , Paszyńska Anna , Paszyński Maciej 
Published: September 2024

AbstractThe Northern European Enclosure Dam (NEED) is a hypothetical project to prevent flooding in European countries following the rising ocean level due to melting arctic glaciers. This project involves the construction of two large dams between Scotland and Norway, as well as England and France. The anticipated cost of this project is 250 to 500 billion euros. In this paper, we present the simulation of the aftermath of flooding on the European coastline caused by a catastrophic break of this hypothetical dam. From our simulation results, we can observe a traveling wave after the accident, with a velocity of approximately 45 kms per hour, raising the sea level permanently inside the dammed region. This observation implies a need to construct additional dams or barriers protecting the Netherlands’ northern coastline and the Baltic Sea’s interior. Our simulations have been obtained using the following building blocks. First, a graph transformation model was applied to generate an adaptive mesh, refined towards the seabed and the seashore topography, approximating the topography of the Earth. We employ the composition graph grammar model to break the mesh’s triangular elements without generating hanging nodes. Second, the wave equation is formulated in a spherical latitude-longitude system of coordinates and solved by a high-order time integration scheme using the generalized $$\alpha$$
α
method. While our paper mainly focuses on the simulation of the NEED dam break, we also provide a stand-alone tool to generate an adaptive mesh of the whole Earth. We can use our software as a stand-alone package in FEniCS or other simulation software.
Photoneuroendocrine, circadian and seasonal systems: from photoneuroendocrinology to circadian biology and medicine
Authors: Korf Horst-Werner 
Published: September 2024

SummaryThis contribution highlights the scientific development of two intertwined disciplines, photoneuroendocrinology and circadian biology. Photoneuroendocrinology has focused on nonvisual photoreceptors that translate light stimuli into neuroendocrine signals and serve rhythm entrainment. Nonvisual photoreceptors first described in the pineal complex and brain of nonmammalian species are luminance detectors. In the pineal, they control the formation of melatonin, the highly conserved hormone of darkness which is synthesized night by night. Pinealocytes endowed with both photoreceptive and neuroendocrine capacities function as “photoneuroendocrine cells.” In adult mammals, nonvisual photoreceptors controlling pineal melatonin biosynthesis and pupillary reflexes are absent from the pineal and brain and occur only in the inner layer of the retina. Encephalic photoreceptors regulate seasonal rhythms, such as the reproductive cycle. They are concentrated in circumventricular organs, the lateral septal organ and the paraventricular organ, and represent cerebrospinal fluid contacting neurons. Nonvisual photoreceptors employ different photopigments such as melanopsin, pinopsin, parapinopsin, neuropsin, and vertebrate ancient opsin. After identification of clock genes and molecular clockwork, circadian biology became cutting-edge research with a focus on rhythm generation. Molecular clockworks tick in every nucleated cell and, as shown in mammals, they drive the expression of more than 3000 genes and are of overall importance for regulation of cell proliferation and metabolism. The mammalian circadian system is hierarchically organized; the central rhythm generator is located in the suprachiasmatic nuclei which entrain peripheral circadian oscillators via multiple neuronal and neuroendocrine pathways. Disrupted molecular clockworks may cause various diseases, and investigations of this interplay will establish a new discipline: circadian medicine.
Noninvasive biomarkers for the detection of GERD-induced pulmonary injury
Authors: Latorre-Rodríguez Andrés R. , Mittal Sumeet K. , Ravichandran Ranjithkumar , Reynolds Austin , Isaza-Restrepo Andrés , Mittal Jahanvi , Hahn Mary F. , Bremner Ross M. , Mohanakumar Thalachallour 
Published: September 2024

Abstract
Background
The role of gastroesophageal reflux in progressive lung damage is increasingly recognized. We have proposed, based on our work with lung transplant recipients, a novel immune mechanism of pulmonary injury after aspiration of gastric contents, during which higher levels of normally sequestered lung self-antigens (SAgs) collagen V (Col-V) and K-alpha-1 tubulin (Kα1T) in circulating small extracellular vesicles (EVs) induce the production of self-antibodies (SAbs) anti-Col-V and anti-Kα1T. Thus, we aimed to determine whether levels of SAbs or SAgs increased in an animal model of aspiration-induced lung damage in a nontransplant setting.

Methods
We created a murine model of repetitive lung aspiration using C57BL/6J mice. Mice were aspirated weekly with 1 mL/kg of hydrochloric acid (n = 9), human gastric contents (n = 9), or combined (1:1) fluid (n = 9) once, three, or six times (n = 3 in each subgroup; control group, n = 9). Blood samples were periodically obtained, and all animals were sacrificed at day 90 for pathological assessment. SAbs were measured using an enzyme-linked immunosorbent assay; SAgs and NF-κB contained in small EVs were assessed by western blot.

Results
Aspirated mice weighed significantly less than controls throughout the study and had histological evidence of pulmonary injury at day 90. Overall, aspirated mice developed higher concentrations of anti-Col-V at day 28 (53.9 ± 28.7 vs. 29.9 ± 4.5 ng/mL, p < 0.01), day 35 (42.6 ± 19.8 vs. 28.6 ± 7.2 ng/mL, p = 0.038), and day 90 (59.7 ± 27.7 vs. 34.1 ± 3.2 ng/mL, p = 0.014) than the control group. Circulating small EVs isolated from aspirated mice on day 90 contained higher levels of Col-V (0.7 ± 0.56 vs. 0.18 ± 0.6 m.o.d., p = 0.009) and NF-κB (0.42 ± 0.27 vs. 0.27 ± 0.09 m.o.d., p = 0.095) than those from controls.

Conclusions
This experimental study supports the theory that gastroesophageal reflux leads to the development of lung damage and an increase of humoral markers that may serve as noninvasive biomarkers to detect asymptomatic lung injury among patients with gastroesophageal reflux disease.
Open versus robotic retromuscular ventral hernia repair: outcomes of the ORREO prospective randomized controlled trial
Authors: Warren Jeremy A. , Blackhurst Dawn , Ewing Joseph A. , Carbonell Alfredo M. 
Published: September 2024

Abstract
Background
Robotic retromuscular ventral hernia repair (rRMVHR) potentially combines the best features of open and minimally invasive VHR: myofascial release with abdominal wall reconstruction (AWR) with the lower wound morbidity of laparoscopic VHR. Proliferation of this technique has outpaced the data supporting this claim. We report 2-year outcomes of the first randomized controlled trial of oRMVHR vs rRMVHR.

Methods
Single-center randomized control trial of open vs rRMVHR. 100 patients were randomized (50 open, 50 robotic). We included patients > 18 y/o with hernias 7–15 cm with at least one of the following: diabetes, chronic obstructive pulmonary disease (COPD), body mass index (BMI) ≥ 30, or current smokers. Primary outcome was occurrence of a composite outcome of surgical site infection (SSI), non-seroma surgical site occurrence (SSO), readmission, or hernia recurrence. Secondary outcomes were length of stay, any SSI or SSO, SSI/SSOPI, operative time, patient reported quality of life, and cost. Analysis was performed in an intention-to-treat fashion. Study was funded by a grant from Society of American Gastrointestinal and Endoscopic Surgeons.

Results
90 patients were available for 30-day and 62 for 2-year analysis (rRMVHR = 46 and 32, oRMVHR = 44 and 30). Hernias in the open group were slightly larger (10 vs 8 cm, p = 0.024) and more likely to have prior mesh (36.4 vs 15.2%; p = 0.030), but were similar in length, prior hernia repairs, mesh use, and myofascial release. There was no difference in primary composite outcome between oRMVHR and rRMVHR (20.5 vs 19.6%, p = 1.000). Median length of stay was shorter for rRMVHR (1 vs 2 days; p < 0.001). All patients had significant improvement in quality of life at 1 and 2 years. Other secondary outcomes were similar.

Conclusion
There is no difference in a composite outcome including SSI, SSOPI, readmission, and hernia recurrence between open and robotic RMVHR.

Graphical abstract
Effect of COVID-19 changes on outcomes and socioeconomic disparities following metabolic and bariatric surgery
Authors: Ahmed Shushmita M. , Johns Alexandra , Timbang Leah , Wang Annie , Singh Navneet Kaur , Lyo Victoria , Ali Mohamed 
Published: September 2024

Abstract
Background
We previously showed worse outcomes among lower socioeconomic status (SES) groups following metabolic/bariatric surgery (MBS). In light of healthcare changes in response to COVID-19, this study aims to evaluate post-pandemic MBS outcomes and determine if prior socioeconomic disparities persisted in the post-COVID era.

Methods
A retrospective chart review of patients undergoing primary Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) between 2015 and 2022 was performed. Patients were stratified into pre- and post-COVID groups. Post-COVID cohort was further stratified into high (HT) and low (LT) tier status based on Distressed Communities Index, a geocoded composite measure of SES. Preoperative characteristics and postoperative outcomes were compared between pre- and post-COVID cohorts, as well as between post-COVID HT and LT groups.

Results
Of 709 patients, 82.9% were pre-COVID and 17.1% were post-COVID. Post-COVID cohort had greater rate of public insurance (46% vs. 37%, p < 0.001), longer wait time to surgery (mean 358 ± 609.8 days vs 241.9 ± 368.5 days, p = 0.045), and were more likely to undergo RYGB (69% vs. 56%, p = 0.010). Post-COVID patients also had lower risk of any complications on multivariable analysis (OR 0.599, 95% CI 0.372–0.963), had higher follow-up rates at post-discharge (95.8% vs 79.7%, p < 0.005), 6-month (93% vs. 82%, p < 0.001) and 12-month visits (75% vs. 63%, p = 0.005), and lost more weight at 12 months (67% excess weight loss (%EWL) vs. 58%EWL, p = 0.002). Among post-COVID HT and LT cohorts, previously seen disparities in complications were no longer seen. Finally, there were no differences in weight or follow-up rates between post-COVID HT and LT.

Conclusions
Post-COVID changes to MBS care have resulted in improved short-term outcomes and reduced disparities for patients of lower SES. Further studies are needed to identify these positive factors to perpetuate practice patterns that optimize care for patients of all socioeconomic status.
Neue Empfehlungen zur palliativen Sedierung
Authors: Surges Séverine Marie , Brunsch Holger , Przyborek Marta , Jaspers Birgit , Radbruch Lukas 
Published: September 2024

ZusammenfassungPalliative Sedierung zielt auf die Linderung von refraktärem Leid bei Patienten mit lebenslimitierender Erkrankung ab. Das Rahmenwerk zur palliativen Sedierung der Europäischen Gesellschaft für Palliativmedizin (European Association for Palliative Care [EAPC]) von 2009 wurde vor Kurzem aktualisiert. In Deutschland wurden von der SedPall-Forschungsgruppe ebenfalls Empfehlungen formuliert. Der vorliegende Beitrag beschreibt die soziale und ethische Komplexität der Entscheidungsfindung und fasst die Empfehlungen zusammen. Die Autonomie des Patienten wird hervorgehoben. Die Bestimmung der Refraktärität des Leids soll gemeinsam von Arzt und Patient vorgenommen werden. Die Sedierung soll proportional erfolgen, das heißt, ihre Form und Dauer werden an die individuelle Situation des Patienten angepasst. Die Entscheidungen zur palliativen Sedierung und zur Hydratation sollen getrennt erfolgen. Midazolam gilt als Medikament der ersten Wahl. Besondere Aufmerksamkeit ist den Angehörigen und dem Behandlungsteam zu widmen.
Pain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV
Authors: Miller Emily A. , McGinnis Kathleen A. , Edelman E. Jennifer , Feinberg Termeh , Gordon Kirsha S. , Kerns Robert D. , Marshall Brandon D. L. , Patterson Julie A. , McRae MaryPeace 
Published: September 2024

AbstractTreatment of opioid use disorder (OUD) with buprenorphine improves outcomes and mortality among people with HIV (PWH). However, engagement is low and is influenced by comorbidities. We examined the impact of patterns of co-occurring pain, substance use disorders (SUDs), and mental health diagnoses on buprenorphine initiation and retention in PWH. The Veterans Aging Cohort Study contained 7,875 patients (2,702 PWH and 5,173 without HIV) with new OUD clinical encounters (2008–2017). Buprenorphine initiation and retention were derived from prescription data. We identified patterns of co-occurring diagnoses (via ICD codes) and assessed the effects of class membership on both outcomes using latent class analysis and regression analyses. The mean age of patients was 55, 98% were male, 58% Black, 8% Hispanic, and only 8% initiated buprenorphine within 12 months of OUD diagnosis. Four classes of co-occurring diagnoses were identified: “Few Co-occurring Diagnoses” (42.3%); “Multiple Pain Conditions” (21.3%); “Pain + SUD” (18.4%) and “Pain + SUD + Mental Health” (18.0%). Patients in the “Pain + SUD” class and “Pain + SUD + Mental Health” class were significantly less likely to initiate buprenorphine and had 59% and 45% lower odds, respectively, of initiating buprenorphine compared with patients in the “Few Co-occurring Diagnoses” class; this effect did not vary by HIV status. Buprenorphine retention was not significantly associated with HIV status or class membership. However, Black Veterans were less likely to initiate or be retained in buprenorphine treatment. Higher comorbidity burden was negatively associated with buprenorphine initiation but not with retention. More research is warranted to determine other factors that may influence treatment retention.
Reducing the computational effort of symbolic supervisor synthesis
Authors: Thuijsman Sander , Hendriks Dennis , Reniers Michel 
Published: September 2024

AbstractSupervisor synthesis is a means to algorithmically derive a supervisory controller from a discrete-event model of a system and a requirements specification. For large systems, synthesis suffers from state space explosion. To mitigate this, synthesis can be applied to a symbolic representation of the models by using Binary Decision Diagrams (BDDs). Peak used BDD nodes and BDD operation count are introduced as deterministic and platform independent metrics to express the computational effort of a symbolic synthesis. These BDD-based metrics are useful to analyze the efficiency of the synthesis algorithm. From this analysis, modifications can be made to how BDDs are handled during synthesis, improving synthesis efficiency. We demonstrate this approach by introducing and analyzing: DCSH, a variable ordering heuristic; several edge ordering heuristics; and an approach to efficiently enforce state exclusion requirements in synthesis. These methods were recently implemented in our open source supervisory control tool: Eclipse ESCET. The analysis is based on large scale experiments of performing synthesis on a variety of models from literature. We show that: (1) by using DCSH, synthesis with high computational effort can be avoided, and generally low computational effort is required, relative to the variable ordering heuristics that were used prior to this work; (2) applying reverse-model edge order realizes relatively low synthesis effort; and (3) state exclusion requirements can efficiently be enforced by restricting edge guards prior to synthesis. While these methods reduce computational effort in practice, it should be noted that they do not affect the theoretical (worst-case) complexity of synthesis.
Abstraction Modulo Stability
Authors: Becchi Anna , Cimatti Alessandro 
Published: September 2024

AbstractThe analysis of legacy systems requires the automated extraction of high-level specifications. We propose a framework, called Abstraction Modulo Stability, for the analysis of transition systems operating in stable states, and responding with run-to-completion transactions to external stimuli. The abstraction captures, in the form of a finite state machine, the effects of external stimuli on the system state. This approach is parametric on a set of predicates of interest and on the definition of stability. We consider some possible stability definitions, which yield different practically relevant abstractions, and propose parametric algorithms for abstraction computation. The framework is evaluated in terms of expressivity and adequacy within an industrial project with the Italian Railway Network, on reverse engineering of relay-based interlocking circuits to extract specifications for a computer-based reimplementation.
Evolving code with a large language model
Authors: Hemberg Erik , Moskal Stephen , O’Reilly Una-May 
Published: September 2024

AbstractAlgorithms that use Large Language Models (LLMs) to evolve code arrived on the Genetic Programming (GP) scene very recently. We present LLM_GP, a general LLM-based evolutionary algorithm designed to evolve code. Like GP, it uses evolutionary operators, but its designs and implementations of those operators significantly differ from GP’s because they enlist an LLM, using prompting and the LLM’s pre-trained pattern matching and sequence completion capability. We also present a demonstration-level variant of LLM_GP and share its code. By presentations that range from formal to hands-on, we cover design and LLM-usage considerations as well as the scientific challenges that arise when using an LLM for genetic programming.
Geodesic vector fields, induced contact structures and tightness in dimension three
Authors: Becker Tilman 
Published: September 2024

AbstractIn this paper, we provide new and simpler proofs of two theorems of Gluck and Harrison on contact structures induced by great circle or line fibrations. Furthermore, we prove that a geodesic vector field whose Jacobi tensor is parallel along flow lines (e.g. if the underlying manifold is locally symmetric) induces a contact structure if the ‘mixed’ sectional curvatures are nonnegative, and if a certain nondegeneracy condition holds. Additionally, we prove that in dimension three, contact structures admitting a Reeb flow which is either periodic, isometric, or free and proper, must be universally tight. In particular, we generalise an earlier result of Geiges and the author, by showing that every contact form on $${\mathbb {R}}^3$$

R

3

whose Reeb vector field spans a line fibration is necessarily tight. Furthermore, we provide a characterisation of isometric Reeb vector fields. As an application, we recover a result of Kegel and Lange on Seifert fibrations spanned by Reeb vector fields, and we classify closed contact 3-manifolds with isometric Reeb flows (also known as R-contact manifolds) up to diffeomorphism.
COSINUS:TES-instrumented NaI Crystals for Direct Dark Matter Search
Authors: Stahlberg M. , Angloher G. , Bharadwaj M. R. , Cababie M. R. , Dafinei I. , Di Marco N. , Einfalt L. , Ferroni F. , Fichtinger S. , Filipponi A. , Frank T. , Friedl M. , Fuss A. , Ge Z. , Heikinheimo M. , Hughes M. N. , Huitu K. , Kellermann M. , Maji R. , Mancuso M. , Pagnanini L. , Petricca F. , Pirro S. , Pröbst F. , Profeta G. , Puiu A. , Reindl F. , Schäffner K. , Schieck J. , Schmiedmayer D. , Schreiner P. , Schwertner C. , Shera K. , Stendahl A. , Stukel M. , Tresca C. , Wagner F. , Yue S. , Zema V. , Zhu Y. 
Published: September 2024

AbstractIn the last years, the COSINUS (Cryogenic Observatory for SIgnals seen in Next generation Underground Searches) experiment has made significant progress both in the construction of its facility and in pursuing its physics goals: At Laboratori Nazionali del Gran Sasso (LNGS) in Italy, an underground facility was constructed, which will house experimental detectors for dark matter direct detection in a dry dilution cryostat. Construction of the main structures at the COSINUS site is finished, including the control building, the cryostat access level, and the water tank which will serve as a Cherenkov muon veto around the cryostat. With a nuclear recoil threshold of 4 keV, the latest COSINUS detector prototype approaches the design goal of 1 keV, and particle discrimination on event-by-event basis has been demonstrated. This contribution gives a brief overview on the status of COSINUS.
An EOQ model incorporating consumer behavior towards marketing policy change
Authors: Kim Seung-Lae , Kim Eunice Y. , Kim Se-Kwon 
Published: September 2024

AbstractThis paper introduces the Markovian EOQ model, an inventory management tool that considers how consumers respond to different marketing strategies. The model uses the Markov process to estimate the demand for two competing brands in a dynamic market. Its purpose is to create a more practical EOQ model that can be used in real-world scenarios where consumers may switch brands due to advertising, promotions, price adjustments, or dissatisfaction. By using the Markovian EOQ model, companies can make better inventory decisions and choose the most effective marketing strategies. One of the assumptions of the model is that the demand in the next period is a function of marketing expenditure in the current period. Our research found that the optimal lot size increases with marketing expenditure but at a slower rate than the traditional EOQ model due to brand loyalty. We provide a numerical example to demonstrate the effectiveness of the model.
Career Imprints from Diverse Institutional Settings: a Comparative Study of Academic and Non-academic Partnered Ventures in Technopolis
Authors: Aktaş Ülkü Neslihan , Akdeve Erdal 
Published: September 2024

AbstractThis research focused on the effects of prior experiences based on the imprinting theory that how individual-level imprints are transferred to the organizational level. The research attempted to answer the question of how owners’ career imprints affect the performance of ventures. Ventures operating in the technology sector were categorized according to their academic and industry background. The results showed that although academic-partnered ventures were found to generate more patents, their performance is lower than non-academic partnered ventures. This research has theoretical and practical contributions providing results that show different institutional contexts lead to different outcomes through the occupational imprinting effect.