bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudio a largo plazo (más de 10 años de evolución), de las complicaciones de las artroplastias trapecio-metacarpianas de tipo ARPE®
Authors: Ferrero M. A. , Pérez C. , Iscar A. , Medrano B. , Rodriguez J. J. , Alsusi H. 
Published: September 2017

Objetivo: La artrosis trapecio-metacarpiana es una patología incapacitante, que produce dolor, disminución de la fuerza, pérdida de destreza en la pinza y limitación de la movilidad del pulgar. Cuando fracasa el tratamiento médico se pueden realizar diferentes técnicas quirúrgicas. Las prótesis totales de la articulación representan una de ellas. Desde mayo de 1999 hasta abril de 2004 se realizaron, de forma consecutiva, un total de 116 prótesis totales de la articulación trapecio-metacarpiana en 103 pacientes que padecían artrosis, utilizando la prótesis no cementada y no constreñida tipo ARPE® (Biomet Spain Orthopaedics SL, Valencia). Se presentan en este estudio los resultados de la revisión clínica, funcional y radiológica de los pacientes revisados durante 10 años de evolución.Material y Método: Los análisis de supervivencia fueron realizados mediante el método de Kaplan-Meier. De los 103 pacientes, 6 fueron excluidos y 97 pacientes, con 109 prótesis acabaron el estudio.Resultados: En la revisión de los 10 años de evolución, 102 (93,6%) eran prótesis funcionales y 7 (6,4%) prótesis eran consideradas prótesis fallidas (3 retiradas por aflojamiento, 3 luxaciones y 1 subluxación y dolor). La probabilidad de supervivencia de Kaplan–Meier fue de 94.1% [CI95% (90.4%,98.8%)]. Radiográficamente, 88 (86,3%) de las prótesis consideradas funcionales no mostraron evidencia de alteraciones del implante y 14 (13,7%) mostraron cambios radio gráficos que eran compatibles con la funcionalidad del implante. Se presenta en detalle el estudio de las complicaciones que han existido, con las posibles soluciones en las cirugías de revisión.Conclusión: La prótesis total de ARPE® ofrece una alternativa de tratamiento segura y fiable en pacientes con artrosis trapecio-metacarpiana grado III y algunos de grado IV con buen capital óseo, sobre todo, en el trapecio. La mayoría de las complicaciones aparecen por defectos de indicación o por defectos de la técnica quirúrgica y se pueden resolver con recambio protésico o con trapecectomía dependiendo de las circunstancias del implante y del paciente.
Endoscopic pancreatic necrosectomy: why scuff when you can flush the muck – make it an easy row to hoe
Authors: Bansal Rinkesh , Puri Rajesh , Choudhary Narendra , Bhatia Sumit , Patel Nisharg , Patle Saurabh , Patil Gaurav , Agarwal Amit , Prabha Chandra , Sud Randhir 
Published: September 2017

Abstract
Background and aims Endoscopic ultrasound (EUS) guided drainage of symptomatic pancreatic walled-off necrosis (WON) followed by fully covered self-expanding metal stent (FCSEMS) placement offers several advantages such as higher technical success rate and the option of necrosectomy. The aim of this study was to evaluate the safety and efficacy of EUS guided drainage of patients with WON by using FCSEMS and intracavitary lavage with a solution containing hydrogen peroxide and adopting a step-up approach.
Methods A prospective open label study was carried out at a single tertiary care center between January 2014 and January 2016. Patients with symptomatic WON who underwent EUS guided drainage followed by FCSEMS placement were included. Primary end points were complete drainage with improvement in symptoms or major adverse events. Secondary end points were minor adverse events related to the procedures.
Results A total of 64 patients (mean age 36 years; 52 males) were included. Technical success was achieved in 100 % of patients and clinical success was achieved in 90.6 %. Complete drainage was achieved with FCSEMS alone in 18 (28.1 %), FCSEMS with necrosectomy using lavage in 40 (62.5 %), FCSEMS with percutaneous drainage (PCD) in 5 (7.8 %), and 1 (1.6 %) patient required salvage surgery. The major adverse event was life threatening bleeding in 3 (4.7 %) patients. Minor adverse events were non-life threatening bleeding in 2 (3.1 %) patients and stent migration in 3 (4.7 %) patients.
Conclusion EUS guided WON drainage with FCSEMS followed by necrosectomy with lavage using a solution containing hydrogen peroxide as a step-up approach is a minimally invasive and effective method with a high technical and clinical success rate. Patients with solid debris > 40 % need aggressive management.
Initiation of Basal Insulin Analog Treatment for Type 2 Diabetes and Reasons Behind Patients’ Treatment Persistence Behavior: Real-World Data from Germany
Authors: Moennig Elisabeth , Perez-Nieves Magaly , Hadjiyianni Irene , Cao Dachuang , Ivanova Jasmina , Klask Ralf 
Published: September 2017

Abstract
Background Poor treatment persistence can affect the real-world effectiveness of insulin therapy. A cross-sectional online survey in 942 patients with type 2 diabetes from 7 different countries evaluated patient experience when initiating basal insulin and the reasons behind insulin persistence patterns. Here, we report the quantitative results for the subset of patients from Germany.
Methods Adults with type 2 diabetes who had initiated basal insulin during the last 3–24 months, identified from market-research panels, participated in the survey. Patients were asked if they had ≥7-day gaps in basal insulin treatment, and were then classified as “continuers” (no gap since starting insulin), “interrupters” (≥1 gap within the first 6 months after starting insulin and subsequently restarted insulin), or “discontinuers” (stopped insulin within the first 6 months after starting and had not restarted at the time of the survey). For each country, 50 participants were planned per persistence category. Enrollment ended if the target quota was reached or enrollment plateaued. Data were analyzed overall and separately for each persistence cohort.
Results The 131 participants from Germany included 55 (42.0%) continuers, 50 (38.2%) interrupters and 26 (19.9%) discontinuers. The most common motivations to initiate basal insulin therapy were encouragement by physician or other healthcare provider (HCP; 54.2%) and expectation to improve glycemic control (42.0%). More than 95% of participants received training before and during insulin initiation (considered as helpful by 81.7%); most (67.2%) preferred in-person training. Continuers more frequently felt that insulin would help to manage diabetes and that their own views were considered when initiating insulin, they reported less concerns and challenges before and during insulin initiation than interrupters or discontinuers. The most common motivations to continue basal insulin were improved glycemic control (72.7%), improved physical well-being (49.1%), and instruction by physician or other HCP (45.5%). The most common reasons contributing to interruption/discontinuation were perceived weight gain (52.0%/50.0%), hypoglycemia (22.0%/38.5%), and potential adverse effects (30.0%/26.9%).
Conclusions Quality interactions between physicians or other HCPs and their patients before and during the initiation of basal insulin may help to manage patient expectations and to improve persistence to insulin therapy.
Gut microbiota and colorectal cancer: insights into pathogenesis for novel therapeutic strategies
Authors: Kang Yongbo , Pan Wei , Cai Yue 
Published: September 2017

AbstractColorectal cancer (CRC), as a leading cause of cancer-related death, is triggered by the complex interplay of host genetics and environmental factors. Mounting evidence has shed light on the association of the gut microbiota dysbiosis with CRC. In CRC experimental models, certain gut microbial strains have been shown to inhibit or attenuate immune responses, indicating that specific species among intestinal commensal bacteria may play either a pathogenic or a protective role in the development of CRC. Oral intake of probiotics/prebiotics can therefore serve as a therapeutic approach for CRC treatment. Microbiota studies in cancer, however, are still at the early stage, lack of quantitative data for clinic application. Fortunately, sequencing-based technologies are a boon to further investigation on the association of the intestinal bacterial flora and human diseases. This review considers the evidence for the role of the gut microbiota in CRC development and progression, responsiveness to immune system, and the related therapeutic applications of probiotics/prebiotics.
Frau Em. Univ.-Prof. Dr. med. Ursula Schmidt-Tintemann 19. Juni 1924 bis 26. Juli 2017
Authors: Mühlbauer W , Biemer E , Steinau H , Olbrisch R , von Mallinckrodt G , Giunta R 
Published: September 2017

Wolfgang MühlbauerAls Plastischer Chirurg der frühen Jahre und langjähriger Weggefährte verdanke ich meiner „Chefin“ die Berufung zur Plastischen Chirurgie,
beginnend mit einer stimulierenden Famulatur im Jahre 1960. Sie wurde gefestigt durch eine 4-monatige Tätigkeit als Medizinalassistent und
entscheidend geprägt durch die Rückholung von der University of Colorado in Denver, USA, wohin ich zur Facharztausbildung gegangen war, ans
neugegründete Universitätsklinikum r.d. Isar 1968. Sie begleitete meinen klinischen, akademischen und berufspolitischen Werdegang bis zur
Neugründung 1984 einer eigenen Abteilung am Klinikum Bogenhausen in München vertrauensvoll und fördernd.All die Jahre versuchte ich ihr
nicht nur in der Klinik eine Stütze zu sein, sondern auch privat in schwierigen Lebenslagen beizustehen, nicht zu Letzt im Sinne unseres
Hypokratischen Eids „unsere Lehrer zu achten, zu ehren bis ans Ende ihres Lebens“.
“I just know”: exploring self-knowledge in chronic obstructive pulmonary disease
Authors: Williams Veronika , Ryan Sara 
Published: September 2017

AbstractThe importance of lay knowledge in health care settings, particularly in relation to long-term conditions, has received increasing attention over the past few decades. However, there remains some way to go before patients’ experiential or self-knowledge forms part of current clinical decision making and care provision. Chronic obstructive pulmonary disease (COPD) is a chronic respiratory condition which affects people on a daily basis. People living with this condition develop experiential knowledge about their symptoms and are, arguably, best placed to assess these and treat any acute worsening of their condition accordingly. Here we explore how people with COPD articulate their knowledge and make sense of it within the context of their everyday lives. We re-analysed data from a qualitative interview-based study with 44 participants living with moderate to severe COPD using a grounded theory approach. We found that participants focused their attention on symptoms and sensations of the chest while developing an embodied self-awareness that allowed them to assess whether they were experiencing an acute worsening of their condition. Participants appeared confident in using this self-knowledge to distinguish such acute flare ups from the daily variability of their condition, described as good days and bad days. We suggest that people with COPD are very attuned to their bodies despite the vagueness and sometimes seemingly unrelated nature of their symptoms and signs. We argue that self-knowledge should be acknowledged as valid and meaningful by both patients and clinicians. This is particularly important because of the clinical uncertainty about the precise onset and presentation of acute exacerbations in COPD.
Massive data compression for parameter-dependent covariance matrices
Authors: Heavens Alan F. , Sellentin Elena , de Mijolla Damien , Vianello Alvise 
Published: September 2017

Abstract
We show how the massive data compression algorithm MOPED can be used to reduce, by orders of magnitude, the number of simulated data sets which are required to estimate the covariance matrix required for the analysis of Gaussian-distributed data. This is relevant when the covariance matrix cannot be calculated directly. The compression is especially valuable when the covariance matrix varies with the model parameters. In this case, it may be prohibitively expensive to run enough simulations to estimate the full covariance matrix throughout the parameter space. This compression may be particularly valuable for the next generation of weak lensing surveys, such as proposed for Euclid and Large Synoptic Survey Telescope, for which the number of summary data (such as band power or shear correlation estimates) is very large, ∼104, due to the large number of tomographic redshift bins which the data will be divided into. In the pessimistic case where the covariance matrix is estimated separately for all points in an Monte Carlo Markov Chain analysis, this may require an unfeasible 109 simulations. We show here that MOPED can reduce this number by a factor of 1000, or a factor of ∼106 if some regularity in the covariance matrix is assumed, reducing the number of simulations required to a manageable 103, making an otherwise intractable analysis feasible.
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese
Authors: Takahashi Yohei , Kou Ikuyo , Ogura Yoji , Miyake Atsushi , Takeda Kazuki , Nakajima Masahiro , Minami Shohei , Kawakami Noriaki , Uno Koki , Ito Manabu , Yonezawa Ikuho , Kaito Takashi , Yanagida Haruhisa , Watanabe Kei , Taneichi Hiroshi , Harimaya Katsumi , Taniguchi Yuki , Kotani Toshiaki , Tsuji Taichi , Suzuki Teppei , Sudo Hideki , Fujita Nobuyuki , Yagi Mitsuru , Chiba Kazuhiro , Kono Katsuki , Sakuma Tsuyoshi , Akazawa Tsutomu , Nishida Kotaro , Kakutani Kenichiro , Shigematsu Hideki , Iida Takahiro , Demura Satoru , Hosogane Naobumi , Okada Eijiro , Nakamura Masaya , Matsumoto Morio , Watanabe Kota , Ikegawa Shiro 
Published: September 2017

Study Design.
Case-only study.

Objective.
The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS.

Summary of Background Data.
Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies.

Methods.
A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle <30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups.

Results.
The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ
2 test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51).

Conclusion.
We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association.

Level of Evidence: 4
Myoelectric and Body-Powered Upper-Limb Prostheses: The Users’ Perspective
Authors: Davis Carrie , St. Onge Mike 
Published: September 2017

ABSTRACT

There are a number of considerations that clinicians weigh when guiding patients through the decision-making processes associated with upper-limb prosthetic rehabilitation. While clinical guidance is essential to such decisions, especially for an individual's first prosthesis, many patients benefit from peer mentoring and interaction. The opportunity to speak to someone who has experienced what they are going through can be extremely valuable and appreciated. Thoughtful clinicians have also benefited from years of listening to the perspectives of their patient clientele. The intent of this article is to present two users' perspectives that canvass some of the various considerations associated with congenital deficiency versus acquired limb amputation, unilateral versus bilateral limb absence, and the perceived benefits associated with body-powered and externally powered systems.
Improving the Quality of Evidence on Upper-Limb Prostheses Through the Standardization of Outcome Measurement
Authors: Resnik Linda 
Published: September 2017

ABSTRACT
This commentary discusses the challenges in conducting systematic reviews of studies comparing upper-limb prostheses given the wide variety of outcome measures used in scientific research. The paper calls for the use of a standardized brief core set of validated outcome measures. A culture change is needed to facilitate widespread adoption of a standardized core set in all routine clinical encounters and research studies. The result will be critically needed data to enable comparison of outcomes of different prosthesis types and components, and ultimately, stronger scientific evidence to assist in clinical and policy decision making.
Attention and Visual Motor Integration in Young Children with Uncorrected Hyperopia
Authors: Kulp Marjean Taylor , Ciner Elise , Maguire Maureen , Pistilli Maxwell , Candy T. Rowan , Ying Gui-shuang , Quinn Graham , Cyert Lynn , Moore Bruce 
Published: September 2017

SIGNIFICANCEAmong 4- and 5-year-old children, deficits in measures of attention, visual-motor integration (VMI) and visual perception (VP) are associated with moderate, uncorrected hyperopia (3 to 6 diopters [D]) accompanied by reduced near visual function (near visual acuity worse than 20/40 or stereoacuity worse than 240 seconds of arc).PURPOSETo compare attention, visual motor, and visual perceptual skills in uncorrected hyperopes and emmetropes attending preschool or kindergarten and evaluate their associations with visual function.METHODSParticipants were 4 and 5 years of age with either hyperopia (≥3 to ≤6 D, astigmatism ≤1.5 D, anisometropia ≤1 D) or emmetropia (hyperopia ≤1 D; astigmatism, anisometropia, and myopia each <1 D), without amblyopia or strabismus. Examiners masked to refractive status administered tests of attention (sustained, receptive, and expressive), VMI, and VP. Binocular visual acuity, stereoacuity, and accommodative accuracy were also assessed at near. Analyses were adjusted for age, sex, race/ethnicity, and parent's/caregiver's education.RESULTSTwo hundred forty-four hyperopes (mean, +3.8 ± [SD] 0.8 D) and 248 emmetropes (+0.5 ± 0.5 D) completed testing. Mean sustained attention score was worse in hyperopes compared with emmetropes (mean difference, −4.1;P< .001 for 3 to 6 D). Mean Receptive Attention score was worse in 4 to 6 D hyperopes compared with emmetropes (by −2.6,P= .01). Hyperopes with reduced near visual acuity (20/40 or worse) had worse scores than emmetropes (−6.4,P< .001 for sustained attention; −3.0,P= .004 for Receptive Attention; −0.7,P= .006 for VMI; −1.3,P= .008 for VP). Hyperopes with stereoacuity of 240 seconds of arc or worse scored significantly worse than emmetropes (−6.7,P< .001 for sustained attention; −3.4,P= .03 for Expressive Attention; −2.2,P= .03 for Receptive Attention; −0.7,P= .01 for VMI; −1.7,P< .001 for VP). Overall, hyperopes with better near visual function generally performed similarly to emmetropes.CONCLUSIONSModerately hyperopic children were found to have deficits in measures of attention. Hyperopic children with reduced near visual function also had lower scores on VMI and VP than emmetropic children.
Fibrous Catalyst–Enhanced Acanthamoeba Disinfection by Hydrogen Peroxide
Authors: Kilvington Simon , Winterton Lynn 
Published: September 2017

SIGNIFICANCE
Hydrogen peroxide (H2O2) disinfection systems are contact-lens-patient problem solvers. The current one-step, criterion-standard version has been widely used since the mid-1980s, without any significant improvement. This work identifies a potential next-generation, one-step H2O2, not based on the solution formulation but rather on a case-based peroxide catalyst.

PURPOSE
One-step H2O2 systems are widely used for contact lens disinfection. However, antimicrobial efficacy can be limited because of the rapid neutralization of the peroxide from the catalytic component of the systems. We studied whether the addition of an iron-containing catalyst bound to a nonfunctional propylene:polyacryonitrile fabric matrix could enhance the antimicrobial efficacy of these one-step H2O2 systems.

METHODS
Bausch + Lomb PeroxiClear and AOSept Plus (both based on 3% H2O2 with a platinum-neutralizing disc) were the test systems. These were tested with and without the presence of the catalyst fabric using Acanthamoeba cysts as the challenge organism. After 6 hours' disinfection, the number of viable cysts was determined. In other studies, the experiments were also conducted with biofilm formed by Stenotrophomonas maltophilia and Elizabethkingia meningoseptica bacteria.

RESULTS
Both control systems gave approximately 1-log10 kill of Acanthamoeba cysts compared with 3.0-log10 kill in the presence of the catalyst (P < .001). In the biofilm studies, no viable bacteria were recovered following disinfection in the presence of the catalyst compared with ≥3.0-log10 kill when it was omitted. In 30 rounds' recurrent usage, the experiments, in which the AOSept Plus system was subjected to 30 rounds of H2O2 neutralization with or without the presence of catalytic fabric, showed no loss in enhanced biocidal efficacy of the material. The catalytic fabric was also shown to not retard or increase the rate of H2O2 neutralization.

CONCLUSIONS
We have demonstrated the catalyst significantly increases the efficacy of one-step H2O2 disinfection systems using highly resistant Acanthamoeba cysts and bacterial biofilm. Incorporating the catalyst into the design of these one-step H2O2 disinfection systems could improve the antimicrobial efficacy and provide a greater margin of safety for contact lens users.
Dural MALT Lymphoma Detected by 11C-Methionine PET/CT
Authors: Annunziata Salvatore , Cuccaro Annarosa , Caldarella Carmelo , Hohaus Stefan 
Published: September 2017

Abstract
A 53-year-old man had a diagnosis of mucosa-associated lymphoid tissue lymphomas of the dura in the left tentorium. The patient underwent whole-body 18F-FDG PET/CT and 11C-methionine PET/CT in order to complete the staging of dural mucosa-associated lymphoid tissue lymphoma. 11C-methionine uptake was detected in multiple meningeal sites, including left tentorium, with no significant FDG uptake in the same regions.