bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-Store Spending Dynamics: How Budgets Invert Relative-Spending Patterns
Authors: Sheehan Daniel , Van Ittersum Koert 
Published: January 2018

Abstract
The authors conduct four controlled lab experiments and one field study in a brick-and-mortar grocery store to demonstrate that relative spending—the price of the purchased item relative to the mean price of the product category—evolves nonlinearly and distinctly for budget and nonbudget shoppers. While the relative spending of budget shoppers evolves in a concave manner, the relative spending of nonbudget shoppers evolves inversely in a convex manner. Thus, budget (nonbudget) shoppers spend relatively more (less) in the middle than at the beginning and toward the end of their shopping trip. Mediation analyses confirm that the pain of paying experienced while shopping drives price salience, which then drives relative spending. Moreover, manipulating shoppers’ pain of paying, by altering the opportunity costs associated with their spending or drawing shoppers’ attention to their spending via real-time spending feedback, is shown to influence these spending patterns. The research offers theoretical contributions to the in-store decision-making, budgeting, and pain-of-paying literature and has important implications for marketing and promotion strategies in retail and mobile technology environments, as it suggests when a shopper may be more sensitive to price-related factors.
Policing Intimate Partner Violence: The ‘Golden Thread’ of Discretion
Authors: Barlow Charlotte , Walklate Sandra 
Published: January 2018

AbstractThis paper offers a critical appreciation of pro-arrest-positive policing policies towards intimate partner violence (IPV). It examines the extent to which such policies, and the research associated with them, have operated within a partial understanding of discretion, which has paid detailed attention to the response of the front-line officer and how that response might be changed either by improved training and/or by rule tightening. Such approaches assume that policing IPV is separate and separable from policing other forms of violence(s) and fail to recognize the wider context of the policing task. This paper makes the case for a more holistic understanding of discretion (to include senior officers) as a way of promoting improved responses to IPV. This also means directing attention to policies and practices in relation to IPV to include police engagement with broader agency and societal responses to IPV. This is the point at which a holistic ‘golden thread’ of discretion can be found.
Mesenteric Oxygenation Changes Associated With Necrotizing Enterocolitis and Pneumoperitoneum After Multiple Blood Transfusions
Authors: Marin Terri , Moore James E. 
Published: January 2018

Background:
The multifactorial pathology and broad clinical presentation of necrotizing enterocolitis (NEC) development in premature infants make prediction of disease onset extremely challenging. Over the past decade, packed red blood cell (PRBC) transfusions have been temporally linked to the development of NEC in severely anemic preterm infants, although this issue is highly controversial.

Purpose:
In this case study, we describe events of an extremely low birth-weight infant who developed NEC complicated by pneumoperitoneum after receiving multiple PRBC transfusions. Specifically, we describe mesenteric tissue oxygenation trend changes as measured by continuous near-infrared spectroscopy (NIRS) technology.

Methods:
As part of a larger prospective, observational investigation, this infant was monitored with NIRS (INVOS 5100C; Medtronic, Boulder, Colorado) before, during, and 48 hours following PRBC transfusions.

Results:
The infant demonstrated severe, prolonged, and persistent reductions in mesenteric tissue oxygenation following blood transfusions, yet routine physiologic monitoring did not indicate intestinal hypoperfusion or impending NEC onset.

Implications for Practice:
This report demonstrates the ability of NIRS to capture possible tissue ischemia during early stages of NEC that may help guide bedside therapeutic interventions.

Implications for Research:
Larger cohort studies to evaluate the ability of NIRS to capture early tissue ischemia are essential to validate the feasibility of adding this technology as a routine clinical bedside tool.

Video Abstract available at
https://journals.lww.com/advancesinneonatalcare/Pages/videogallery.aspx.
Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain
Authors: Remeniuk Bethany , King Tamara , Sukhtankar Devki , Nippert Amy , Li Nancy , Li Fuying , Cheng Kejun , Rice Kenner C. , Porreca Frank 
Published: January 2018

Abstract
Metastasis of cancer to the skeleton represents a debilitating turning point in the lives of patients. Skeletal metastasis leads to moderate to severe ongoing pain along with bone remodeling that can result in fracture, events that dramatically diminish quality of life. Interleukin-6 (IL-6) levels are elevated in patients with metastatic breast cancer and are associated with a lower survival rate. We therefore determined the consequences of inhibition of IL-6 signaling using a novel small molecule antagonist, TB-2-081, on bone integrity, tumor progression, and pain in a rodent model of breast cancer. Rat MAT B III mammary adenocarcinoma cells were injected and sealed within the tibia of female Fischer rats. Growth of these cells within the rat tibia elicited increased IL-6 levels both within the bone exudate and in the plasma, produced ongoing pain and evoked hypersensitivity, and bone fracture that was observed by approximately day 12. Systemic TB-2-081 delivered by subcutaneous osmotic minipumps starting at tumor implantation prevented tumor-induced ongoing bone pain and evoked hypersensitivity without altering tumor growth. Remarkably, TB-2-081 infusion significantly reduced osteolytic and osteoblastic bone remodeling and time to fracture likely by decreasing osteoclastogenesis and associated increase in bone resorption. These findings indicate that blockade of IL-6 signaling may represent a viable, disease-modifying strategy to prevent tumor-induced bone remodeling allowing for stabilization of bone and decreased fractures as well as diminished ongoing pain that may improve quality of life of patients with skeletal metastases. Notably, anti-IL-6 antibodies are clinically available allowing for rapid testing of these possibilities in humans.
Forensic Nursing State of the Science: Research and Practice Opportunities
Authors: Drake Stacy A. , Koetting Cathy , Thimsen Kathi , Downing Nancy , Porta Carolyn , Hardy Peggy , Valentine Julie L. , Finn Cris , Engebretson Joan 
Published: January 2018

ABSTRACT

Introduction:
The International Association of Forensic Nurses (IAFN) is the only nursing organization advancing the forensic nursing specialty. The organization seeks to advance the profession, and one mechanism for doing so is development of a research agenda.

Methods:
The purpose of this action-based research study was to aid in the development of a forensic nursing research agenda. The study was carried out in two integral stages: (a) focus groups with IAFN members attending the annual conference and (b) reviewing posted IAFN member listserv material.

Results:
The findings of this study identified similar gaps of other nursing specialties experiencing “growing pains,” including role confusion and variation in educational preparation.

Conclusion:
Findings from this study will inform development of the IAFN 5-year research agenda to advance forensic nursing science and evidence-based practice.
Therapeutic Advances in Hyponatremia: Fluids, Diuretics, Vaptans, and More
Authors: Yang Shu , Goldin Mark 
Published: January 2018

Background:
Hyponatremia is frequently encountered in geriatric patients and is associated with significant morbidity and mortality. Traditional management approaches have targeted underlying causes—such as volume repletion with normal saline in dehydrated patients, loop diuretics and fluid restriction in hypervolemic patients, and fluid restriction and salt tablets in euvolemic patients. Elderly patients are at particular risk of hypovolemic hyponatremia because of dehydration, as well as the syndrome of inappropriate antidiuretic hormone. In addition to fluid restriction, syndrome of inappropriate antidiuretic hormone may be treated with demeclocycline, lithium, and urea, although these agents are limited by side effects. Loop diuretics are standard therapy for hyponatremia in congestive heart failure, cirrhosis, or nephrotic syndrome; although these agents, and to a greater extent thiazide diuretics, can cause hyponatremia and should be used cautiously. In severe hyponatremia, standard therapy is the infusion of hypertonic (3%) saline. Judicious monitoring is paramount, as rapid overcorrection is associated with central pontine myelinolysis.

Areas of Uncertainty:
Although these therapies are well established, the gravity of improper sodium correction has led to uncertainty and varying dosing strategies. Hypertonic saline infusion rates may be weight based or standardized and can be used concurrently with deamino-delta-d-arginine vasopressin. As well, loop diuretics vary considerably in metabolism and half-life, and choice of agent may have implications for mortality in congestive heart failure. Finally, even the simple strategy of fluid restriction may not apply to patients with highly concentrated urine.

Therapeutic Advances:
Unresolved questions around treatment of hyponatremia have spurred development of newer therapeutics, notably arginine vasopressin receptor blockers or vaptans, which have been shown to be effective in the treatment of euvolemic and hypervolemic chronic hyponatremia. In 2 randomized, double-blind, placebo-controlled multicenter trials (SALT-1 and SALT-2), tolvaptan significantly increased serum sodium at days 4 and 30 in 448 patients with mean baseline serum sodium 129 meq/L. Furthermore, vaptans can cause liver damage, and the FDA has cautioned against their use in patients with underlying liver disease. The cost of vaptans has been a major barrier, but this may be offset by decreases in length of stay in hospitalized patients.

Conclusions:
Vaptans have shown promise in the treatment of euvolemic and hypervolemic chronic hyponatremia but have not shown long-term mortality benefits.
Reversal of Anticoagulation: Therapeutic Advances and Clinical Guidelines
Authors: Goldin Mark , Hughes Gregory J. , Choudhary Zunaira , Tariq Sara , Shafeeq Hira , Cohen Jessica 
Published: January 2018

Background:
Anticoagulants are life-saving medications that prevent and treat thromboembolic disease and are of particular importance in the elderly population for prevention of stroke in atrial fibrillation. The advent of direct oral anticoagulants and reversal agents has yielded more options for patients, although complicating clinical decision-making.

Areas of Uncertainty:
The decision to anticoagulate in atrial fibrillation depends on the risks of stroke versus bleeding. The accompanying HAS-BLED score for predicting bleeding allows an estimation of net clinical benefit. Despite these tools, uncertainty remains. Notably, anticoagulation has traditionally been avoided in patients with recurrent falls. Yet, decision analytic modeling has shown that patients on warfarin would need hundreds of falls annually to warrant discontinuation. At the same time, direct oral anticoagulants, while theoretically simpler to dose than warfarin, should be dose-reduced or avoided in cases of renal impairment, extreme age or weight, or concomitant use of strong P-glycoprotein and/or CYP3A4 inducers/inhibitors.

Therapeutic Advances:
Prothrombin complex concentrates consist of endogenous coagulation factors and anticoagulants. One 4-factor prothrombin complex concentrates (factors II, VII, IX, X, proteins C, and S), when administered with intravenous vitamin K, effectively reversed warfarin in cases of life-threatening bleeding or need for urgent surgery/procedure in 2 phase IIIb trials, although it may be associated with thrombogenesis. Idarucizumab, a humanized monoclonal antibody, reversed dabigatran-associated bleeding in 11.4 hours in a late-stage trial and had no effect on thrombin in pharmacodynamic studies. Andexanet alfa, a recombinant molecule derived from factor X, is a class-specific reversal agent for factor Xa inhibitors. In trials of healthy individuals (ANNEXA-A, ANNEXA-R), andexanet alfa reversed apixaban and rivaroxaban, although increased levels of d-Dimer and prothrombin fragments 1 and 2, suggesting potential thrombogenesis; the later stage ANNEXA-4 trial is ongoing. Finally, ciraparantag, a small water-soluble molecule, reversed edoxaban and enoxaparin in phase 1/2 trials (by whole blood clotting time), and holds promise as a potential universal reversal agent.
Improving Antibiotic Prescribing for Children With Urinary Tract Infection in Emergency and Urgent Care Settings
Authors: Poole Nicole M. , Kronman Matthew P. , Rutman Lori , Weissman Scott J. , Migita Russell T. , Caglar Derya , Zerr Danielle M. 
Published: January 2018

Objectives
Children with urinary tract infection (UTI) are often diagnosed in emergency and urgent care settings and increasingly are unnecessarily treated with broad-spectrum antibiotics. This study evaluated the effect of a quality improvement intervention on empiric antibiotic prescribing for the treatment of uncomplicated UTI in children.

Methods
A local clinical pathway for uncomplicated UTI, introduced in June 2010, recommended empiric treatment with cephalexin, a narrow-spectrum (first-generation) cephalosporin antibiotic. A retrospective quasi-experimental study of pediatric patients older than 1 month presenting to emergency and urgent care settings from January 1, 2009, to December 31, 2014, with uncomplicated UTI was conducted. Hospitalized patients and those with chronic conditions or urogenital abnormalities were excluded. Control charts and interrupted time-series analysis were used to analyze the primary outcome of narrow-spectrum antibiotic prescribing rates and the balancing measures of 72-hour revisits, resistant bacterial isolates, and subsequent inpatient admissions for UTI.

Results
A total of 2134 patients were included. There was an immediate and sustained significant increase in cephalexin prescribing before (19.2%) versus after (79.6%) pathway implementation and a concurrent significant decline in oral third-generation cephalosporin (cefixime) prescribing from 50.3% to 4.0%. There was no significant increase in 72-hour revisits, resistant bacterial isolates, or inpatient admissions for UTI.

Conclusions
A clinical pathway produced a significant and sustained increase in narrow-spectrum empiric antibiotic prescribing for pediatric UTI. Increased empiric cephalexin prescribing did not result in increased treatment failures or adverse patient outcomes. Future studies on implementing clinical pathways for children outside a pediatric hospital network are needed.
The Effect of Early Knowledge of Respiratory Syncytial Virus Positivity on Medical Decision Making and Throughput Time Within the Pediatric Emergency Department
Authors: Schnell Jessica , Schroeder Lisa , Sinclair Kelly , Patel Lina , Dowd Denise 
Published: January 2018

Objective
The aim of this study was to evaluate whether early knowledge of respiratory syncytial virus (RSV) positivity by rapid triage-based testing protocol improved emergency department (ED) throughput time and decreased ED ancillary testing and antibiotic administration.

Methods
A retrospective cohort study was performed of ED patients aged 2 to 12 months, presenting November 1 to March 31 for the years 2008–2013. Included patients presented with fever and upper respiratory tract symptoms. Patients were excluded if they tested positive for influenza, had chronic underlying medical problems, or were admitted or transferred from an outside facility or if no RSV result was documented. The study group was compared with infants who tested negative for RSV by the triage-based protocol and were diagnosed as having (1) bronchiolitis and (2) a viral illness.

Results
Of 899 patients tested for RSV within triage, the study included 713 (79%); 231 (35.3%) tested positive for RSV. When comparing children diagnosed as having bronchiolitis, there was no statistically significant difference between RSV positive and negative in ED throughput time, ED administered antibiotics, or chest radiographs, urine analyses, blood cultures, or lumbar punctures obtained. When comparing children diagnosed as having a viral illness, RSV-positive patients had less chest radiographs, urine analysis, and blood cultures performed.

Conclusions
Identifying the virus responsible for bronchiolitis through a triage-based protocol does not decrease ED throughput time, antibiotic administration, or chest radiographs, urine analysis, or blood cultures obtained. In infants presenting with upper respiratory tract symptoms and fever, knowing RSV infectivity through a triage-based protocol does significantly decrease chest radiographs, urine analysis, and blood cultures obtained.
Accessory Spleen Fracture
Authors: Chauvet Eline , Spyropoulou Vasiliki , Anooshiravani-Dumont Mehrak , Sanchez Oliver , Lacroix Laurence 
Published: January 2018

Abstract
Accessory spleen rupture may occur after blunt abdominal trauma or, more rarely, spontaneously. Although only few cases are described in adults, it is even more uncommon in children. We report the case of a 13-year-old boy with traumatic accessory spleen fracture. After a review of the literature, we discuss the diagnostic points that should raise the suspicion for accessory spleen fracture as well as how challenging the diagnosis by computed tomography can be.
Stabilization of golden cages by encapsulation of a single transition metal atom
Authors: Li Hui-Fang , Wang Huai-Qian 
Published: January 2018

Golden cage-doped nanoclusters have attracted great attention in the past decade due to their remarkable electronic, optical and catalytic properties. However, the structures of large golden cage doped with Mo and Tc are still not well known because of the challenges in global structural searches. Here, we report anionic and neutral golden cage doped with a transition metal atom MAu
16
(M = Mo and Tc) using Saunders ‘Kick' stochastic automation search method associated with density-functional theory (DFT) calculation (SK-DFT). The geometric structures and electronic properties of the doped clusters, MAu
16

q

(M = Mo and Tc;
q
= 0 and −1), are investigated by means of DFT theoretical calculations. Our calculations confirm that the 4d transition metals Mo and Tc can be stably encapsulated in the Au
16
−
cage, forming three different configurations, i.e. endohedral cages, planar structures and exohedral derivatives. The ground-state structures of endohedral cages
C
2v
Mo@Au
16
−
-(a) and C
1
Tc@Au
16
−
-(b) exhibit a marked stability, as judged by their high binding energy per atom (greater than 2.46 eV), doping energy (0.29 eV) as well as a large HOMO–LUMO gap (greater than 0.40 eV). The predicted photoelectron spectra should aid in future experimental characterization of MAu
16
−
(M = Mo and Tc).
Comparative RNA-seq based transcriptomic analysis of Aspergillus nidulans recombinant strains overproducing heterologous glycoside hydrolases
Authors: Calzado Felipe , Zubieta Mariane P. , Persinoti Gabriela F. , Fanchini Terrasan Cesar Rafael , Rubio Marcelo V. , Contesini Fabiano J. , Squina Fabio M. , Damasio André 
Published: January 2018

ABSTRACTFilamentous fungi are important cellular factories for the production and secretion of homologous and heterologous enzymes such as carbohydrate-active enzymes. However, the regulation of protein secretion in these microorganisms requires more profound studies since the enzyme levels produced are usually below the levels required by industry for profitable processes. Genomic and transcriptomic approaches have been used to understand the overexpression and production of heterologous enzymes and their capacity to induce different cellular biological processes. To investigate this regulation, Aspergillus nidulans recombinant strains were analyzed by transcriptomics. We designed three A. nidulans recombinant strains producing the following heterologous proteins: alpha-arabinofuranosidase (AbfA), beta-glucosidase (BglC) and thermophilic mannanase (Tp-Man5). The heterologous genes abfA and bglC were highly expressed, while tp-man5 mRNA levels were low and similar to those of a reference gene. There was an indirect relationship between mRNA and protein secretion levels, suggesting that transcription is not a bottleneck for target gene expression in this system. Despite the distinct features of the recombinant proteins, 30 differentially expressed genes were common to all the recombinant strains, suggesting that these genes represent a general response to the expression of heterologous genes. We also showed that the early activation of the canonical unfolded protein response (UPR) pathway by hacA alternative splicing was normalized after 8h, except in the strain expressing BglC, suggesting either no accumulation of the BglC misfolded form or the presence of an alternative endoplasmic reticulum (ER) stress and UPR pathway. Finally, to focus our analysis on the secretion pathway, a set of 374 genes was further evaluated. Seventeen genes were common to all the recombinant strains, suggesting again that these genes represent a general response of A. nidulans cells to the overexpression of recombinant genes, even thermophilic genes. Additionally, we reported the possible genetic interactions of these 17 genes based on coexpression network calculations. Interestingly, protein improvements are nongeneric, and improvements in the production of one target protein are not necessarily transferable to another one. Thus, this study may provide genetic and cellular background and targets for genetic manipulation to improve protein secretion by A. nidulans.
DAtest: a framework for choosing differential abundance or expression method
Authors: Russel Jakob , Thorsen Jonathan , Brejnrod Asker D. , Bisgaard Hans , Sørensen Søren J. , Burmølle Mette 
Published: January 2018

AbstractDAtest is an R package for directly comparing different statistical methods for differential abundance and expression analysis on a dataset of interest; be it data from RNA-seq, proteomics, metabolomics or a microbial marker-gene survey. A myriad of statistical methods exists for conducting these analyses, and with this tool we give the analyst an empirical foundation for choosing a method suitable for a specific dataset. The package supports categorical and quantitative variables, paired/block experimental designs, and the inclusion of covariates. It is freely available at GitHub: https://github.com/Russel88/DAtest along with detailed instructions.