bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Hepatobiliary Scintigraphy and Ultrasonography in the Diagnosis of Biliary Atresia in Infant with Neonatal Jaundice – Experiences in NINMAS
Authors: Sultana Nasreen , Jabin Zeenat , Bashir Md , Parveen Rahima , Begum Shamim MF , Begum Rokeya , Islam Saiful 
Published: December 2017

Objective: The purpose of this study was to determine whether gall bladder visualization can help to exclude the biliary atresia in hepatobiliary scintigraphic studies of infants with persistent jaundice.Methods: This is a retrospective study carried out at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS). Study subjects include infants with neo-natal jaundice who underwent Hepatobiliary scintigraphies for suspected biliary atresia and study period was 2 years. Food was withheld for 4 hours before the examination. Anterior images of liver and gall bladder were taken after i/v administration of 2 -3 mci 99m Tc labeled Brida (HIDA) at 5 min interval for 2 hours then at 4 hours and 24 hours. Non-visualization of bowel activity in HIDA scan in 24hours delayed images was considered as cases of diagnosis of biliary atresia.Results: Thirty-six patients were included in this retrospective study. Patent biliary channels was seen by scintigraphies in 17(47%) patients and biliary atresia was seen in 19(52%) patients. By abdominal US non- visualization of gall bladder were found in 25(69%) cases and gall bladder visualized in 11(30%) cases. Eight (22%) of 36 patients had biopsy confirmed biliary atresia; all of these had positive scintigraphies and (60%) had positive sonographic findings. Among the 5 false-positive scintigraphies caused by hepatic dysfunction and 2 had normal sonography. Thirty-six patients had periscintigraphic sonography. There were 25/36 (61%) abnormal studies, which included cases with small gallbladder (n = 8) and non-visualized gallbladder (n = 17), but not periportal fibrosis.Conclusion: Gall bladder was usually visible on Hepatobiliary scintigraphy of fasting patients with biliary patency. Both hepatobiliary scintigraphy and sonography are currently the standard imaging investigations for suspected biliary atresia. The complementary role, in which scintigraphy and sonography are important, and recommend follow-up imaging reassessment before making definitive surgical decisions. This will serve to decrease the frequency of false-positive imaging diagnoses of biliary atresia, and hence, avoid unnecessary surgeries.Bangladesh J. Nuclear Med. 18(1): 51-53, January 2015
Ni fait, ni à faire : Chambord, un château à choix multiples
Authors: Bryant Simon , Travers Cécile 
Published: December 2017

Cette communication est l’occasion de présenter le panorama des recherches menées depuis une quinzaine d’années sur le monument et son environnement proche - dépouillements d’archives, études sur le tufeau et les dégradations de la pierre, relevés photogrammétriques, modélisations en 3D de l’édifice - et de parler des interventions archéologiques qui se sont enchaînées depuis 1996 (fouilles programmées, diagnostics archéologiques, fouilles préventives). Ces recherches ont permis d’aborder de façon très concrète les origines mouvementées du chantier Renaissance, ainsi que la vie du château au XVIIIe siècle. La question de l’environnement de l’édifice a pris progressivement de l’importance et a généré des recherches spécifiques sur le bourg, le domaine, la forêt, et tout dernièrement sur les jardins. Nous livrons ici un premier aperçu des informations issues de la fouille des parterres nord réalisée durant l’été 2016 dans le cadre d’un projet de restauration des jardins. Les données sont en cours de traitement et semblent particulièrement prometteuses pour la connaissance de l’évolution du site et de sa mise en valeur progressive depuis le XVIe siècle. Elles ont aussi confirmé l’existence du grand jardin d’agrément de style régulier, créé dans les années 1730 devant les façades nord et est du château, et apporté des éléments de connaissance très précis quant aux dispositions paysagères originelles de ce premier jardin.
Coquillages et coquilles au château de Versailles aux xviie et xviiie siècles : entre repas et rocailles de fontaines
Authors: Dupont Catherine 
Published: December 2017

L’étude des coquilles découvertes lors des fouilles archéologiques de Versailles a permis de mettre en évidence l’arrivée de ces mollusques marins sous deux formes aux XVIIe et XVIIIe siècles : celle de l’animal vivant et celle de la coquille dépourvue de la chair de l’animal. L’analyse des huîtres plates de la Grille royale témoigne de leur acheminement à Versailles vivantes, dans le but d’être consommées. L’observation de leur surface montre que ces coquilles ont sans doute été nettoyées avant d’être transportées. Les faunes incrustées permettent aussi de décrire les caractéristiques des environnements d’où elles proviennent. D’autres coquilles ont, quant à elles, été recherchées pour leur esthétique et non pour leur vertu alimentaire. Elles ont été découvertes au sein des bosquets de la Reine, ancien Labyrinthe, et du Rond vert, redevenu récemment Théâtre d’eau. Leur analyse montre que la nacre était une matière recherchée. Ces coquilles reflètent, de par leur aspect et leurs origines multiples, le prestige des lieux. Elles participent à la mode du rocaillage, une pratique architecturale qui consistait à mélanger des matériaux naturels (pierre, galets, coquilles…).
The Cell Surface Estrogen Receptor, G Protein- Coupled Receptor 30 (GPR30), is Markedly down Regulated during Breast Tumorigenesis
Authors: Poola Indira , Abraham Jessy , Liu Aiyi , Marshalleck Josephine J. , Dewitty Robert L. 
Published: December 2017

Background GPR30 is a cell surface estrogen receptor that has been shown to mediate a number of non-genomic rapid effects of estrogen and appear to balance the signaling of estrogen and growth factors. In addition, progestins appear to use GPR30 for their actions. Therefore, GPR30 could play a critical role in hormonal regulation of breast epithelial cell integrity. Deregulation of the events mediated by GPR30 could contribute to tumorigenesis. Methods To understand the role of GPR30 in the deregulation of estrogen signaling processes during breast carcinogenesis, we have undertaken this study to investigate its expression at mRNA levels in tumor tissues and their matched normal tissues. We compared its expression at mRNA levels by RT quantitative real-time PCR relative to GAPDH in ERα”—positive (n = 54) and ERα”—negative (n = 45) breast cancer tissues to their matched normal tissues. Results We report here, for the first time, that GPR30 mRNA levels were significantly down-regulated in cancer tissues in comparison with their matched normal tissues (p < 0.0001 by two sided paired t-test). The GPR30 expression levels were significantly lower in tumor tissues from patients (n = 29) who had lymph node metastasis in comparison with tumors from patients (n = 53) who were negative for lymph node metastasis (two sample t-test, p < 0.02), but no association was found with ERα, PR and other tumor characteristics. Conclusions Down-regulation of GPR30 could contribute to breast tumorigenesis and lymph node metastasis.
A Decade of Change: An Institutional Experience with Breast Surgery in 1995 and 2005
Authors: Guth Amber A. , Shanker Beth Ann , Roses Daniel F. , Axelrod Deborah , Singh Baljit , Toth Hildegard , Shapiro Richard L. , Hiotis Karen , Diflo Thomas , Cangiarella Joan F. 
Published: December 2017

Introduction With the adoption of routine screening mammography, breast cancers are being diagnosed at earlier stages, with DCIS now accouting for 22.5% of all newly diagnosed breast cancers. This has been attributed to both increased breast cancer awareness and improvements in breast imaging techniques. How have these changes, including the increased use of image-guided sampling techniques, influenced the clinical practice of breast surgery? Methods The institutional pathology database was queried for all breast surgeries, including breast reconstruction, performed in 1995 and 2005. Cosmetic procedures were excluded. The results were analysed utilizing the Chi-square test. Results Surgical indications changed during 10-year study period, with an increase in preoperatively diagnosed cancers undergoing definitive surgical management. ADH, and to a lesser extent, ALH, became indications for surgical excision. Fewer surgical biopsies were performed for indeterminate abnormalities on breast imaging, due to the introduction of stereotactic large core biopsy. While the rate of benign breast biopsies remained constant, there was a higher percentage of precancerous and DCIS cases in 2005. The overall rate of mastectomy decreased from 36.8% in 1995 to 14.5% in 2005. With the increase in sentinel node procedures, the rate of ALND dropped from 18.3% to 13.7%. Accompanying the increased recognition of early-stage cancers, the rate of positive ALND also decreased, from 43.3% to 25.0%. Conclusions While the rate of benign breast biopsies has remained constant over a recent 10-year period, fewer diagnostic surgical image-guided biopsies were performed in 2005. A greater percentage of patients with breast cancer or preinvasive disease have these diagnoses determined before surgery. More preinvasive and Stage 0 cancers are undergoing surgical management. Earlier stage invasive cancers are being detected, reflected by the lower incidence of axillary nodal metastases.
A Model for Traffic Accidents Prediction Based on Driver Personality Traits Assessment
Authors: Čubranić-Dobrodolac Marjana , Lipovac Krsto , Čičević Svetlana , Antić Boris 
Published: December 2017

The model proposed in this paper uses four psychological instruments for assessing driver behaviour and personality traits aiming to find a relationship between the considered constructs and the occurrence of traffic accidents. A Barratt Impulsiveness Scale (BIS-11) was used for the assessment of impulsivity, Aggressive Driving Behaviour Questionnaire (ADBQ) for assessing the aggressiveness while driving, Manchester Driver Attitude Questionnaire (DAQ) and the Questionnaire for self-assessment of driving ability. Besides these instruments, the participants filled out an extensive demographic survey. Within the statistical analysis, in addition to the descriptive indicators, correlation coefficients were calculated and four hierarchical regression analyses were performed to determine the predictive power of personality traits on the occurrence of traffic accidents. Further, to confirm the results and to obtain additional information about the relationship between the considered variables, the structural equation modelling and binary logistic regression have been implemented. A sample of this research covered 305 drivers, of which there were 100 bus drivers and 102 truck drivers, as well as 103 drivers of privately owned vehicles. The results indicate that BIS-11 and ADBQ questionnaires show the best predictive power which means that impulsivity and aggressiveness as personality traits have the greatest influence on the occurrence of traffic accidents. This research could be useful in many fields, such as the design of selection procedures for professional drivers, development of programs for the prevention of traffic accidents and violations of law, rehabilitation of drivers who have been deprived of the driving license, etc.
Pregabalin for Neuropathic Pain and Itch in Recessive Dystrophic Epidermolysis Bullosa
Authors: Calvo Margarita , Tejos-Bravo Macarena , Passi-Solar Alvaro , Espinoza Fernanda , Fuentes Ignacia , Lara-Corrales Irene , Pope Elena 
Published: October 2024

ImportancePatients with recessive dystrophic epidermolysis bullosa (RDEB) experience neuropathic pain and itch. There is a lack of evidence on any treatment for these symptoms in patients with RDEB.ObjectivesTo test the efficacy of pregabalin in the treatment of neuropathic pain and itch in patients with RDEB.Design, Setting, and ParticipantsA randomized, double-blinded, crossover trial of oral pregabalin (50-300 mg/d) vs placebo was conducted at 2 sites, Toronto (Canada) and Santiago (Chile) from January 1, 2019, to December 31, 2020. Patients eligible to participate were diagnosed with RDEB, aged 8 to 40 years, not pregnant or lactating (if female), and had evidence of probable neuropathic pain and itching defined as distal thermal sensory loss (confirmed by thermal roller), score of 4 or greater on the Douleur Neuropathique 4 questionnaire (DN4), and score greater than 4 on the 10-point visual analog scale [VAS]). Patients with a clinically important or poorly controlled medical or psychiatric condition or pregabalin intolerance or allergy were excluded. Of 41 patients screened, 3 were not eligible and 28 declined enrollment. Data analyses were performed in 2021 through 2023.InterventionParticipants received both pregabalin and matched placebo (titrated to a maximum-tolerated dose of 300 mg/day) in a randomized sequence so that comparisons could be made within participants and between groups.Main Outcomes and MeasuresDifference in the mean pain and itch scores between pregabalin and placebo treatment (measured using VAS) before and after intervention.ResultsIn all, 10 participants were randomized to 2 groups, 6 patients (mean [SD] age, 26.7 [8.1] years; 3 females [50%]) in group 1, and 4 patients (mean [SD] age, 26.5 [7.8] years, 2 females [50%]) in group 2. Group 1 received a sequence of pregabalin-placebo while group 2 received placebo-pregabalin. Pregabalin significantly reduced mean (SD) pain scores by 1.9 (1.5) points when controlling for sequence and treatment period vs baseline, while placebo had 0.1 (2.0) points of reduction. The effect of pregabalin was a mild but significant reduction in itch compared to baseline (mean [SD] points, 0.9 [2.2]), whereas the placebo produced no reduction (0.1 [2.5]). The mean pregabalin dose was generally well tolerated.Conclusions and RelevanceThe results of this randomized crossover trial indicate that pregabalin significantly reduced pain and itch scores from baseline compared to placebo in patients with RDEB. This feasibility study provided preliminary data on the efficacy of pregabalin in managing pain and itch in RDEB and gathered essential data to inform the design of a larger cohort trial.Trial RegistrationClinicalTrials.gov Identifier: NCT03928093
The effect of disaster case management on housing recovery: Analysis of disaster survivor support in Sendai City using the synthetic control method
Authors: Kawami Fuminori , Tatsuki Shigeo 
Published: October 2024

AbstractThis study investigated how disaster case management (DCM) and disaster public housing reconstruction influence housing recovery using 4 open‐data sources. The trends in the number of households under designated temporary housing in Sendai and 18 other cities in Miyagi Prefecture were analyzed. The results revealed that both DCM and the reconstruction of public housing for disaster recovery promote housing restoration from temporary housing. Finally, Mary Richmond's discussion of wholesale and retail methods was used to elucidate policy implications for disaster victim support.
Analyzing Protection Motivation Theory and Cognitive Failures in Texting While Driving Behavior Among Young Drivers
Authors: Gabaldon Janeth , Niranjan Suman , Hawkins Timothy G. , McBride Maranda E. , Savitskie Katrina 
Published: October 2024

ABSTRACTTexting while driving (TWD) poses a significant hazard, particularly among young adults, as it requires simultaneous engagement in competing tasks. Despite widespread awareness of its dangers, drivers continue to engage in TWD. This study investigates the psychological and cognitive factors that influence TWD, employing the protection motivation theory (PMT). Structural equation modeling was conducted on a sample of 674 survey respondents aged 18–25. Factors influencing TWD behavior were revealed, including response cost, threat vulnerability, cognitive failure, self‐efficacy, and threat severity. Response cost was the primary barrier. Notably, not all subdimensions of threat appraisal and coping appraisal have a direct impact on TWD; cognitive failures serve as a mediator solely between threat vulnerability and response cost. An understanding of TWD provides insights into the TWD behavior of young drivers. By integrating the PMT with cognitive failure, this approach informs the development of interventions and regulations aimed at discouraging TWD and improving road safety.
Ultralow Concentration Nonflammable Electrolytes Mediated by Intermolecular Interactions for Safer Potassium‐Ion Sulfur Batteries
Authors: Li Qian , Liu Gang , Kumar Pushpendra , Zhao Fei , Wang Yuqi , Cai Tao , Chen Yinghua , Xie Hongliang , Wahyudi Wandi , Ma Zheng , Ming Jun 
Published: October 2024

AbstractDesigning electrolytes that are compatible with graphite anodes and possess flame‐retardant features is strongly demanded in potassium‐ion batteries (PIBs) to inhibit solvent co‐insertion and graphite exfoliation, and also stabilize the highly active potassium‐based species (e.g., KC8). Herein, a nonflammable electrolyte is designed by introducing the fluoroethers to stabilize graphite anodes, particularly at an ultralow concentration (<0.43 m) that is rarely reported before. It is discovered that intermolecular interactions can form between the 1,1,2,2‐tetrafluoroethyl‐2,2,3,3‐tetrafluoropropyl ether (i.e., HFE) diluent and trimethyl phosphate (TMP) flame‐retardant by electronegative fluorine (δ−F) and electropositive hydrogen (δ+H). The intermolecular interactions can change the potassium ion (K+) solvation structure (e.g., weakening the K+‐TMP interaction), and then determine the properties of the K+‐solvent‐anion complex at the electrode interface. a molecular interfacial model is presented with a new coordination mechanism involving the diluent to elucidate the relationship between the intermolecular interactions and electrode performance (i.e., K+‐solvent co‐insertion, or reversible K+ (de)intercalation) at the molecular scale, facilitating the design of high safety and high energy density potassium‐ion sulfur batteries. This study sheds light on the importance of intermolecular interactions to tune electrolyte properties and also opens new avenues for designing electrolytes for safe and practical PIBs.
Pitaya‐Inspired Metal‐Organic Framework Nanozyme for Multimodal Imaging‐Guided Synergistic Cuproptosis, Nanocatalytic Therapy, and Photothermal Therapy
Authors: Yue Quer , Zeng Qingbin , Guo Qianni , Zhao Xiuchao , Yuan Yaping , Yang Yuqi , Jiang Weiping , Zhou Xin 
Published: October 2024

AbstractNature often provides invaluable insights into technological innovation and the construction of nanomaterials. Inspired by the pitaya fruit's strategy of wrapping seeds within its pulp to enhance seed survival, a unique nanocomposite based on metal‐organic framework (MOF)‐encapsulated CuS nanoparticles (NPs) is developed. This design effectively addresses the challenge of short retention time afforded by CuS NPs for therapeutic and imaging purposes. The MOF acts as the “pitaya pulp” protecting the internal CuS NPs (“pitaya seeds”), thereby increasing their retention time in vivo. This system exhibits triple‐enzyme‐mimicking activities and is proposed for application in photoacoustic and magnetic resonance imaging‐guided therapies, including chemodynamic therapy, photothermal therapy, and cuproptosis‐related therapy. The exceptional enzyme‐mimicking activities of superoxide dismutase, catalase, and peroxidase not only produce oxygen to alleviate hypoxia but also generate a reactive oxygen species (ROS) storm for effective tumor destruction. By combining these multienzymatic properties, superior photothermal performance, and Cu‐induced cuproptosis, nanozyme‐treated mice exhibited an 84% inhibition of tumor growth—approximately double the effect observed in mice treated with CuS NPs alone. This study presents a smart strategy for integrating imaging with therapeutic modalities, achieving exceptional outcomes for precise imaging‐guided tumor therapy.
Low Fibrillation Lyocell Fiber: Analysis of Fiber and its Crosslinking Agent
Authors: Guo Yaoxian , Li Ting , Cheng Chunzu , Xu Jigang , Ma Xuele , Cheng Min , Zhang Jiayu , Guo Shanping 
Published: October 2024

AbstractIn this paper, the hydrolysis process of Dichlorohydroxytriazine (NHDT) under alkaline conditions are studied. A qualitative and quantitative method for the determination of HNDT and its hydrolysis products are established, which further clarified the hydrolysis mechanism of NHDT. Under alkaline conditions, the hydrolysis products are mainly compound 4, compound 6 and chloride (Cl−). The hydrolysis rate of NHDT at different NaOH concentration and temperature is studied. This research can be used to guide the high efficiency preparation of low fibrillation Lyocell fiber. According to the quantitative detection of wet abrasion numbers and the qualitative analysis of the fiber by SEM after slapping, it is concluded that the low fibrillation Lyocell fiber is less prone to fibrillation under the combined action of wet state and mechanical force. Due to hydrolysis of the unreacted second chlorine resulting in harmful products on the low fibrillation Lyocell fiber, the fibrillation propensity increased with the increase of storage time. The mechanical properties of low fibrillation Lyocell fiber prepared under different fiber states are studied. The tensile breaking strength of low fibrillation Lyocell fiber prepared in the form of sequentially arranged fiber bundles are better, which is closely related to the fiber surface.
Integrated Functionality of Photothermal Hydrogels and Membranes in Solar Water, Chemical, Mechanical, and Electrical Domains
Authors: Ong Wei Li , Lu Wanheng , Zhang Tianxi , Ho Ghim Wei 
Published: October 2024

AbstractSolar energy can be harnessed and converted into heat via the photothermal effect, which can then be utilized to drive many other reactions to produce important resources, such as water, fuel, electricity, and even mechanical actuation in a clean and sustainable manner. Hydrogels and membranes coupled with photothermal materials are particularly suitable for this purpose because they possess advantageous properties, such as porosity and adaptability. These properties allow for the introduction of diverse additives and functionalities, ensuring that photothermal systems can be customized for specific tasks, thereby enhancing their overall performance, functionality and versatility. This review aims to provide an overview of recent developments and the significance of employing photothermal hydrogels and membranes in multiple fields ranging from clean water, fuel production, electricity generation to mechanical actuation, followed by a discussion on key considerations in materials design and engineering. Finally, the review addresses the challenges and future directions of photothermal applications.