bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time modelling of wavepackets in turbulent jets
Authors: Sasaki Kenzo , Piantanida Selene , Cavalieri André V. G. , Jordan Peter 
Published: May 2017

Three methods are considered for estimating the downstream evolution of wavepackets in turbulent jets based on upstream measurements. The parabolised stability equations are used to compute a transfer function between axially and radially separated points in the flow, and the performance of this theoretical model is compared with that of two empirical approaches, direct transfer function calculation and autoregressive moving-average exogenous system identification, both of which require unsteady experimental data. The three approaches, which perform equally well, prove suitable for estimation of the downstream evolution of wavepackets using pressure data measured in the near-nozzle region. Over distances of the order of a couple of jet diameters, correlations of up to 80 % are observed between estimation and measurement. The performance deteriorates as axial separation between input and output is increased. While the two empirical approaches are limited in terms of both the number of input–output pairs and the number of flow variables that can be reasonably considered, the parabolised stability equations-based approach has no such limitation and can be used to perform full-field estimates comprising all of the dependent variables; in this it constitutes a potentially formidable means by which to perform single-input–multiple-output estimation. It has the further advantage of not requiring unsteady data for its construction, the only necessary ingredients being the mean flow and the linearised equations of motion.
Laminar hypersonic leading edge separation – a numerical study
Authors: Khraibut Amna , Gai S. L. , Brown L. M. , Neely A. J. 
Published: May 2017

This paper describes laminar hypersonic leading edge separation. Such a configuration of separated flow was originally studied by Chapman et al. (NACA Tech. Rep. 1356, 1958) at supersonic Mach numbers as it is particularly amenable to theoretical analysis and assumes no pre-existing boundary layer. It can be considered as a limiting case of much studied generic configurations such as separation at a compression corner and separated flow behind a base. A numerical investigation is described using a compressible Navier–Stokes solver assuming perfect gas air, no slip boundary condition and a non-catalytic surface. A moderate enthalpy flow of $3.1\times 10^{6}~\text{J}~\text{kg}^{-1}$ with a unit Reynolds number of $1.34\times 10^{6}~\text{ m}^{-1}$ and a Mach number of 9.66 was considered. The resulting separated flow is analysed in the context of viscous–inviscid interaction and interpreted in terms of ‘triple-deck’ concepts. Particular emphasis is given to wall temperature effects. The effects of strong to moderate wall cooling on flow in the separated region as well as on processes of separation, reattachment and separation length, are highlighted. The numerical simulations have also shown the existence of a secondary eddy embedded within the primary recirculation region, with its size, shape and position, being strongly affected by the wall temperature.
Thermo-Mechanical Multiscale Modeling in Plasticity of Metals Using Small Strain Theory
Authors: Munjas N. , Čanađija M. , Brnić J. 
Published: May 2017

AbstractA numerical coupled thermoplasticity multiscale procedure for small strain analysis is developed in the finite element environment. It is suitable for simulation of thermo-mechanical behavior and overall response of metallic materials, using standard approximation method based on the concept of representative volume element (RVE). The local level isothermal analysis that models the micro-scale, is fully coupled to the global level non-isothermal analysis. The global macro-scale tangent stiffness operator is obtained using numerical differentiation procedure using the forward difference scheme. The numerical procedure is developed for two-dimensional problems, using Abaqus user-defined subroutines. Applicability of the proposed framework is presented on several representative examples.
A HARMONIZED EUROPEAN COMPANY LAW: ARE WE THERE ALREADY?
Authors: Enriques Luca 
Published: May 2017

AbstractTo what extent is EU company law harmonized? This article first makes the point that little progress has been made in the direction of company law uniformity within the EU. It then argues that, even leaving aside the question of whether it would be desirable to have a uniform EU company law, that outcome is simply impossible to achieve, due to interest group resistance and the variety in national meta-rules. Yet it concludes that, in a narrow meaning, European company laws have indeed been harmonized: European Member States company laws fit together, which may well be what harmonization, not only etymologically, is all about.
Mixing for three-term progressions in finite simple groups
Authors: PELUSE SARAH 
Published: May 2017

AbstractAnswering a question of Gowers, Tao proved that anyA×B×C⊂ SLd(𝔽q)3contains |A||B||C|/|SLd(𝔽q)| +Od(|SLd(𝔽q)|2/qmin(d−1,2)/8) three-term progressions (x,xy,xy2). Using a modification of Tao's argument, we prove such a mixing result for three-term progressions in all nonabelian finite simple groups except for PSL2(𝔽q) with an error term that depends on the degree of quasirandomness of the group. This argument also gives an alternative proof of Tao's result whend> 2, but with the error termO(|SLd(𝔽q)|2/q(d−1)/24).
Modeling the Social Dynamics of Moral Enhancement
Authors: SANDBERG ANDERS , FABIANO JOAO 
Published: May 2017

Abstract:How individuals tend to evaluate the combination of their own and other’s payoffs—social value orientations—is likely to be a potential target of future moral enhancers. However, the stability of cooperation in human societies has been buttressed by evolved mildly prosocial orientations. If they could be changed, would this destabilize the cooperative structure of society? We simulate a model of moral enhancement in which agents play games with each other and can enhance their orientations based on maximizing personal satisfaction. We find that given the assumption that very low payoffs lead agents to be removed from the population, there is a broadly stable prosocial attractor state. However, the balance between prosociality and individual payoff-maximization is affected by different factors. Agents maximizing their own satisfaction can produce emergent shifts in society that reduce everybody’s satisfaction. Moral enhancement considerations should take the issues of social emergence into account.
Human Enhancement and the Story of Job
Authors: AGAR NICHOLAS , MCDONALD JOHNNY 
Published: May 2017

Abstract:This article explores some implications of the concept of transformative change for the debate about human enhancement. A transformative change is understood to be one that significantly alters the value an individual places on his or her experiences or achievements. The clearest examples of transformative change come from science fiction, but the concept can be illuminatingly applied to the enhancement debate. We argue that it helps to expose a threat from too much enhancement to many of the things that make human lives valuable. Among the things threated by enhancement are our relationships with other human beings. The potential to lose these relationships provides a compelling reason for almost all humans to reject too much enhancement.
Enhancing a Person, Enhancing a Civilization: A Research Program at the Intersection of Bioethics, Future Studies, and Astrobiology
Authors: ĆIRKOVIĆ MILAN M. 
Published: May 2017

Abstract:There are manifold intriguing issues located within largely unexplored borderlands of bioethics, future studies (including global risk analysis), and astrobiology. Human enhancement has for quite some time been among the foci of bioethical debates, but the same cannot be said about its global, transgenerational, and even cosmological consequences. In recent years, discussions of posthuman and, in general terms, postbiological civilization(s) have slowly gained a measure of academic respect, in parallel with the renewed interest in the entire field of future studies and the great strides made in understanding of the origin and evolution of life and intelligence in their widest, cosmic context. These developments promise much deeper synergic answers to questions regarding the long-term future of enhancement: how far can it go? Is human enhancement a further step toward building a true postbiological civilization? Should we actively participate and help shape this process? Is the future of humanity “typical” in the same Copernican sense as our location in space and time is typical in the galaxy, and if so, can we derive important insights about the evolutionary pathways of postbiological evolution from astrobiological and Search for ExtraTerrestrial Intelligence (SETI) studies? These and similar questions could be understood as parts of a possible unifying research program attempting to connect cultural and moral evolution with what we know and understand about their cosmological and biological counterparts.
Simulated Mortality—We Can Do More
Authors: GOLDBERG ANDREW T. , HELLER BENJAMIN J. , HOCHKEPPEL JESSE , LEVINE ADAM I. , DEMARIA SAMUEL 
Published: May 2017

Abstract:High-fidelity simulation (HFS) is a relatively new teaching modality, which is gaining widespread acceptance in medical education. To date, dozens of studies have proven the usefulness of HFS in improving student, resident, and attending physician performance, with similar results in the allied health fields. Although many studies have analyzed the utility of simulation, few have investigated why it works. A recent study illustrated that permissive failure, leading to simulated mortality, is one HFS method that can improve long-term performance. Critics maintain, however, that the use of simulated death is troubling and excessive. Given the controversy regarding simulated death, we consider the data about the educational value and the emotional harms associated with them, expecting that evidence could be useful in resolving the question. The goal of this narrative review is to explore the argument against simulated mortality and provide educators with an imperative as to why it can be safely utilized.
Anomalous left atrial drainage of the right superior caval vein with partial anomalous pulmonary venous return
Authors: Sulaiman Sherief , Nair Rajesh G. 
Published: May 2017

AbstractWe present a case of anomalous direct connection of the right superior caval vein to the left atrium. The diagnosis was made in a 2-year-old child with unexplained cyanosis and apparently normal heart. Corrective surgery was performed, and the child recovered completely.
Human MSCs promotes colorectal cancer epithelial–mesenchymal transition and progression via CCL5/β-catenin/Slug pathway
Authors: Chen Ke , Liu Qianqian , Tsang Lai Ling , Ye Qiao , Chan Hsiao Chang , Sun Yunwei , Jiang Xiaohua 
Published: May 2017

AbstractMesenchymal stem cells (MSCs) extensively interact with cancer cells and other stroma cells in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) progression and metastasis is controversial. This study was designed to identify the role of inflammation-activated-MSCs in CRC development. Our results show that tumor necrosis factor (TNF)-α-preactivated-hMSCs significantly promote the progression of colon cancer cells by enhancing cell proliferation, epithelial–mesenchymal transition, migration, and invasion. TNF-α-primed-hMSCs secrete high level of CCL5, which interacts with its receptor CCR1 expressed in colon cancer cells. Interestingly, the stimulation of colon cancer cell progression by TNF-α-primed hMSCs is associated with the upregulation ofβ-catenin signaling pathway. Blockingβ-catenin pathway significantly decreases the TNF-α-primed-conditioned medium or CCL5-mediated cancer cell progression by decreasing the enhancement of Slug, suggesting that the CCL5/β-catenin/Slug pathway plays a critical role in hMSC-mediated cancer progression. Furthermore,in vivomodel in nude mice confirms the ability of hMSCs to promote the proliferation and progression of colon cancer cells, and the upregulation of CCl5/β-catenin/Slug pathway. Taken together, the present study has demonstrated a novel pathway involving CCl5/CCR1/β-catenin/Slug, via which hMSCs promotes CRC development.
Skilful prediction of Sahel summer rainfall on inter-annual and multi-year timescales
Authors: Sheen K. L. , Smith D. M. , Dunstone N. J. , Eade R. , Rowell D. P. , Vellinga M. 
Published: May 2017

AbstractSummer rainfall in the Sahel region of Africa exhibits one of the largest signals of climatic variability and with a population reliant on agricultural productivity, the Sahel is particularly vulnerable to major droughts such as occurred in the 1970s and 1980s. Rainfall levels have subsequently recovered, but future projections remain uncertain. Here we show that Sahel rainfall is skilfully predicted on inter-annual and multi-year (that is, >5 years) timescales and use these predictions to better understand the driving mechanisms. Moisture budget analysis indicates that on multi-year timescales, a warmer north Atlantic and Mediterranean enhance Sahel rainfall through increased meridional convergence of low-level, externally sourced moisture. In contrast, year-to-year rainfall levels are largely determined by the recycling rate of local moisture, regulated by planetary circulation patterns associated with the El Niño-Southern Oscillation. Our findings aid improved understanding and forecasting of Sahel drought, paramount for successful adaptation strategies in a changing climate.
miR-29b contributes to multiple types of muscle atrophy
Authors: Li Jin , Chan Mun Chun , Yu Yan , Bei Yihua , Chen Ping , Zhou Qiulian , Cheng Liming , Chen Lei , Ziegler Olivia , Rowe Glenn C. , Das Saumya , Xiao Junjie 
Published: May 2017

AbstractA number of microRNAs (miRNAs, miRs) have been shown to play a role in skeletal muscle atrophy, but their role is not completely understood. Here we show that miR-29b promotes skeletal muscle atrophy in response to different atrophic stimuli in cells and in mouse models. miR-29b promotes atrophy of myotubes differentiated from C2C12 or primary myoblasts, and conversely, its inhibition attenuates atrophy induced by dexamethasone (Dex), TNF-α and H2O2 treatment. Targeting of IGF-1 and PI3K(p85α) by miR-29b is required for induction of muscle atrophy. In vivo, miR-29b overexpression is sufficient to promote muscle atrophy while inhibition of miR-29b attenuates atrophy induced by denervation and immobilization. These data suggest that miR-29b contributes to multiple types of muscle atrophy via targeting of IGF-1 and PI3K(p85α), and that suppression of miR-29b may represent a therapeutic approach for muscle atrophy induced by different stimuli.
Negative Poisson’s ratio in 1T-type crystalline two-dimensional transition metal dichalcogenides
Authors: Yu Liping , Yan Qimin , Ruzsinszky Adrienn 
Published: May 2017

AbstractMaterials with a negative Poisson’s ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour—becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and electronic structure of a material. Here, using first-principles calculations, we report a class of auxetic single-layer two-dimensional materials, namely, the 1T-type monolayer crystals of groups 6–7 transition-metal dichalcogenides, MX2(M=Mo, W, Tc, Re; X=S, Se, Te). These materials have a crystal structure distinct from all other known auxetic materials. They exhibit an intrinsic in-plane negative Poisson’s ratio, which is dominated by electronic effects. We attribute the occurrence of such auxetic behaviour to the strong coupling between the chalcogenporbitals and the intermetalt2g-bonding orbitals within the basic triangular pyramid structure unit. The unusual auxetic behaviour in combination with other remarkable properties of monolayer two-dimensional materials could lead to novel multi-functionalities.
Inverse Tunnel Magnetocapacitance in Fe/Al-oxide/Fe3O4
Authors: Kaiju Hideo , Nagahama Taro , Sasaki Shun , Shimada Toshihiro , Kitakami Osamu , Misawa Takahiro , Fujioka Masaya , Nishii Junji , Xiao Gang 
Published: May 2017

AbstractMagnetocapacitance (MC) effect, observed in a wide range of materials and devices, such as multiferroic materials and spintronic devices, has received considerable attention due to its interesting physical properties and practical applications. A normal MC effect exhibits a higher capacitance when spins in the electrodes are parallel to each other and a lower capacitance when spins are antiparallel. Here we report an inverse tunnel magnetocapacitance (TMC) effect for the first time in Fe/AlOx/Fe3O4 magnetic tunnel junctions (MTJs). The inverse TMC reaches up to 11.4% at room temperature and the robustness of spin polarization is revealed in the bias dependence of the inverse TMC. Excellent agreement between theory and experiment is achieved for the entire applied frequency range and the wide bipolar bias regions using Debye-Fröhlich model (combined with the Zhang formula and parabolic barrier approximation) and spin-dependent drift-diffusion model. Furthermore, our theoretical calculations predict that the inverse TMC effect could potentially reach 150% in MTJs with a positive and negative spin polarization of 65% and −42%, respectively. These theoretical and experimental findings provide a new insight into both static and dynamic spin-dependent transports. They will open up broader opportunities for device applications, such as magnetic logic circuits and multi-valued memory devices.
UROPA: a tool for Universal RObust Peak Annotation
Authors: Kondili Maria , Fust Annika , Preussner Jens , Kuenne Carsten , Braun Thomas , Looso Mario 
Published: May 2017

﻿﻿﻿﻿AbstractThe annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (such as ATAC-seq), but also from other types of predictions that result in genomic ranges. While peak annotation primarily driven by ChiP-seq was extensively explored, many approaches remain simplistic (“most closely located TSS”), rely on fixed pre-built references, or require complex scripting tasks on behalf of the user. An adaptable, fast, and universal tool, capable to annotate genomic ranges in the respective biological context is critically missing. UROPA (Universal RObust Peak Annotator) is a command line based tool, intended for universal genomic range annotation. Based on a configuration file, different target features can be prioritized with multiple integrated queries. These can be sensitive for feature type, distance, strand specificity, feature attributes (e.g. protein_coding) or anchor position relative to the feature. UROPA can incorporate reference annotation files (GTF) from different sources (Gencode, Ensembl, RefSeq), as well as custom reference annotation files. Statistics and plots transparently summarize the annotation process. UROPA is implemented in Python and R.
Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock
Authors: Subramani Kumar , Lu Sumin , Warren Marie , Chu Xiaogang , Toque Haroldo A. , Caldwell R. William , Diamond Michael P. , Raju Raghavan 
Published: May 2017

AbstractHemorrhagic shock is a leading cause of death in people under the age of 45 and accounts for almost half of trauma-related deaths. In order to develop a treatment strategy based on potentiating mitochondrial function, we investigated the effect of the orphan drug dichloroacetate (DCA) on survival in an animal model of hemorrhagic shock in the absence of fluid resuscitation. Hemorrhagic shock was induced in rats by withdrawing 60% of the blood volume and maintaining a hypotensive state. The studies demonstrated prolonged survival of rats subjected to hemorrhagic injury (HI) when treated with DCA. In separate experiments, using a fluid resuscitation model we studied mitochondrial functional alterations and changes in metabolic networks connected to mitochondria following HI and treatment with DCA. DCA treatment restored cardiac mitochondrial membrane potential and tissue ATP in the rats following HI. Treatment with DCA resulted in normalization of several metabolic and molecular parameters including plasma lactate and p-AMPK/AMPK, as well as Ach-mediated vascular relaxation. In conclusion we demonstrate that DCA can be successfully used in the treatment of hemorrhagic shock in the absence of fluid resuscitation; therefore DCA may be a good candidate in prolonged field care following severe blood loss.
Seismic anisotropy evidence for dehydration embrittlement triggering intermediate-depth earthquakes
Authors: Wang Jian , Zhao Dapeng , Yao Zhenxing 
Published: May 2017

AbstractIt has been proposed that dehydration embrittlement of hydrous materials can trigger intermediate-depth earthquakes and form a double seismic zone in a subducting slab. Seismic anisotropy may provide a possible insight into intermediate-depth intraslab seismicity, because anisotropic properties of minerals change with varying water distribution, temperature and pressure. Here we present a high-resolution model of P-wave radial anisotropy tomography of the Japan subduction zone down to ~400 km depth, which is obtained using a large number of arrival-time data of local earthquakes and teleseismic events. Our results reveal a close correlation between the pattern of intermediate-depth seismicity and anisotropic structures. The seismicity occurs in portions of the Pacific and Philippine Sea slabs where positive radial anisotropy (i.e., horizontal velocity being faster than vertical one) dominates due to dehydration, whereas the inferred anhydrous parts of the slabs are found to be aseismic where negative radial anisotropy (i.e., vertical velocity being faster than horizontal one) dominates. Our anisotropic results suggest that intermediate-depth earthquakes in Japan could be triggered by dehydration embrittlement of hydrous minerals in the subducting slabs.
Automated screening for Fragile X premutation carriers based on linguistic and cognitive computational phenotypes
Authors: Movaghar Arezoo , Mailick Marsha , Sterling Audra , Greenberg Jan , Saha Krishanu 
Published: May 2017

AbstractMillions of people globally are at high risk for neurodegenerative disorders, infertility or having children with a disability as a result of the Fragile X (FX) premutation, a genetic abnormality in FMR1 that is underdiagnosed. Despite the high prevalence of the FX premutation and its effect on public health and family planning, most FX premutation carriers are unaware of their condition. Since genetic testing for the premutation is resource intensive, it is not practical to screen individuals for FX premutation status using genetic testing. In a novel approach to phenotyping, we have utilized audio recordings and cognitive profiling assessed via self-administered questionnaires on 200 females. Machine-learning methods were developed to discriminate FX premutation carriers from mothers of children with autism spectrum disorders, the comparison group. By using a random forest classifier, FX premutation carriers could be identified in an automated fashion with high precision and recall (0.81 F1 score). Linguistic and cognitive phenotypes that were highly associated with FX premutation carriers were high language dysfluency, poor ability to organize material, and low self-monitoring. Our framework sets the foundation for computational phenotyping strategies to pre-screen large populations for this genetic variant with nominal costs.