bluuebunny/crossref_metadata_2025_split huggingface dataset:
The flavonoid derivative 4′-nitro-6-hydroxyflavone suppresses the activity of HNF4α and stimulates the degradation of HNF4α protein through the activation of AMPK
Authors: Inoue Jun , Ikeda Shiori , Kanayama Tomohiko , Sato Ryuichiro 
Published: May 2017

Abstract
Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor that regulates the expression of genes involved in a number of critical metabolic pathways. The modulation of HNF4α activity is thought to be a promising drug target pathway for hyperlipidemia. To identify compounds that reduce the activity of HNF4α, we conducted luciferase reporter assays using the promoter region of microsomal triglyceride transfer protein (MTP) gene, which contains an HNF4α-responsive element. Using this system, we show here that the flavonoid derivative 4′-nitro-6-hydroxyflavone (NOHF) suppresses MTP promoter activity. Treatment with NOHF caused a decrease in the expression of the HNF4α target gene. We also identified that NOHF triggers the AMP-activated protein kinase (AMPK) and accelerates the degradation of HNF4α protein. Knock-down of AMPK diminishes the effect of NOHF. These results indicate that NOHF is an AMPK activator and attenuates the transcriptional activity of HNF4α, at least in part, by accelerating HNF4α protein degradation.
A comparison of solute clearance and ultrafiltration volume in peritoneal dialysis with total or fractional (50%) intraperitoneal volume exchange with the same dialysate flow rate.
Authors: Aasarød K , Widerøe T E , Flakne S C 
Published: May 2017

Abstract
BACKGROUND: The most efficient way to perform automated peritoneal dialysis (APD) has not yet been defined. Tidal peritoneal dialysis (TPD) has been claimed to be more efficient than traditional intermittent peritoneal dialysis (IPD), but few comparative studies have been done keeping dialysate flow the same in the two treatment techniques. METHODS: Six patients were treated with 10, 14 and 24 litres total dialysis fluid volume during 9 h (flow rate 18.5, 25.9 and 44.4 ml/min), receiving the treatments both as IPD and TPD. Glucose concentration in the fluid was held constant during all treatments. Transperitoneal clearances (ml/min) for urea, creatinine and uric acid and ultrafiltration volume was calculated, and comparisons made between TPD and IPD. The total intraperitoneal dwell time was calculated for each treatment session. A peritoneal equilibration test was also done for each patient. RESULTS: The ratio of the creatinine concentration in dialysate to the concentration in plasma at 4 h obtained with the peritoneal equilibration test (PET) averaged 0.77 (range 0.69-0.82). Urea clearance was higher for IPD than for TPD with 10 litres: 14.3 +/- 2.4 and 13.3 +/- 2.7 (P = 0.0092). For 14 and 24 litres urea clearance for IPD and TPD was 16.9 +/- 2.3 and 15.9 +/- 3.5 (n.s.) and 20.9 +/- 3.6 and 19.9 +/- 5.6 (n.s.) respectively. Creatinine clearance was higher for IPD than for TPD with 10 litres: 9.6 +/- 1.3 and 8.9 +/- 1.3 (P = 0.0002). For 14 and 24 litres creatinine clearance for IPD and TPD was 11.0 +/- 0.7 and 9.9 +/- 2.0 (n.s.) and 12.3 +/- 1.2 and 12.4 +/- 2.2 (n.s.) respectively. Uric acid clearance was higher for IPD than for TPD with 10 litres: 8.4 +/- 1.3 and 7.7 +/- 1.0 (P = 0.0054). For 14 and 24 litres uric acid clearance for IPD and TPD was 9.3 +/- 1.7 and 8.9 +/- 2.2 (n.s.) and 11.3 +/- 2.9 and 10.6 +/- 2.6 (n.s.) respectively. IPD gave significantly higher ultrafiltration volume (ml) than IPD for both 10 and 14 litres: 944 +/- 278 and 783 +/- 200 (P = 0.0313) and 1147 +/- 202 and 937 +/- 211 (P = 0.0478). For 24 litres there was no significant difference between IPD and TPD: 1220 +/- 224 and 1253 +/- 256. CONCLUSION: With the lowest dialysate flow rate (18.5 ml/min), solute clearance and ultrafiltration volume was higher on IPD than on TPD. With the intermediate flow rate (25.9 ml/min) the ultrafiltration volume was higher on IPD, but no difference was found for solute clearance. With the highest flow rate (44.4 ml/min) there was no difference neither for ultrafiltration nor for solute clearances.
Cutaneous Plasmacytosis: A Clinicopathologic Study of a Series of Cases and Their Treatment Outcomes
Authors: Han Xiuhui Debra , Lee Siong See Joyce , Tan Suat Hoon , Chong Wei-Sheng , Ng See Ket , Ooi Melissa Gaik Ming , Goh Chee Leok 
Published: May 2017

Introduction:
Cutaneous plasmacytosis (CP) is a rare skin disorder characterized by multiple reddish brown nodules with polyclonal plasma cell proliferation. It has most often been reported to affect the trunk but is also known to affect the face and extremities in adults and is predominantly seen in Asians. The etiology is poorly understood, and there is no consensus on treatment methods.

Methods:
Five cases diagnosed to have CP were collated from our institution. Their clinicopathologic features and treatment outcomes were reviewed.

Results:
Four of the 5 patients presented with lesions that affected multiple sites of the body including the trunk, axillae, face, and limbs. The remaining patient had lesions localized to his axillae. The lesions were generally asymptomatic. All patients had hypergammaglobulinaemia but only one had a faint monoclonal band detected on immunofixation. Common findings in the biopsy results for all patients were perivascular plasma cell infiltrates without light chain restriction on kappa/lambda staining, as well as mast cell infiltrates. Partial remission of cutaneous lesions was observed in 3 of the patients, with 2 of them responding well to psoralen and ultraviolet A radiation therapy.

Conclusion:
CP presents with distinctive clinical features and characteristic histological features including polyclonal perivascular plasma cell infiltrates. The axilla seems to be a frequent and characteristic site of involvement and may be a useful clinical clue to the condition. In the management of patients with CP, it is important to exclude secondary causes of plasmacytic infiltrates. While there are no clearly established treatment modalities for CP, psoralen and ultraviolet A radiation therapy may be a viable option in view of the clinical improvement observed in our patients who received it.
Commensal bacterial modulation of the host immune response to ameliorate pain in a murine model of chronic prostatitis
Authors: Murphy Stephen F. , Schaeffer Anthony J. , Done Joseph D. , Quick Marsha L. , Acar Utkucan , Thumbikat Praveen 
Published: May 2017

Abstract
The human commensal microflora plays an essential role in modulating the immune response to control homeostasis. Staphylococcus epidermidis, a commensal bacterium most commonly associated with the skin exerts such effects locally, modulating local immune responses during inflammation and preventing superinfection by pathogens such as Staphylococcus aureus. Although the prostate is considered by many to be sterile, multiple investigations have shown that small numbers of gram-positive bacterial species such as S. epidermidis can be isolated from the expressed prostatic secretions of both healthy and diseased men. Chronic pelvic pain syndrome is a complex syndrome with symptoms including pain and lower urinary tract dysfunction. It has an unknown etiology and limited effective treatments but is associated with modulation of prostate immune responses. Chronic pelvic pain syndrome can be modeled using murine experimental prostatitis (EAP), where CD4+ve IL17A+ve T cells have been shown to play a critical role in disease orchestration and development of pelvic tactile allodynia. Here, we report that intraurethral instillation of a specific S. epidermidis strain (designated NPI [non–pain inducing]), isolated from the expressed prostatic secretion of a healthy human male, into EAP-treated mice reduced the pelvic tactile allodynia responses and increased CD4+ve IL17A+ve T-cell numbers associated with EAP. Furthermore, a cell wall constituent of NPI, lipoteichoic acid, specifically recapitulates these effects and mediates increased expression of CTLA4-like ligands PDL1 and PDL2 on prostatic CD11b+ve antigen-presenting cells. These results identify a new potential therapeutic role for commensal S. epidermidis NPI lipoteichoic acid in the treatment of prostatitis-associated pain.
Effects of a Nurse-Led Phone Follow-up Education Program Based on the Self-efficacy Among Patients With Cardiovascular Disease
Authors: Zhou Yan , Liao Jiali , Feng Fangming , Ji Mengting , Zhao Chunyan , Wang Xiaofang 
Published: May 2017

Background:
The integration of self-efficacy (SE) theory within a nurse-led telephone follow-up education program (NP-FEP) has not been extensively evaluated for patients with cardiovascular disease.

Objectives:
The aim of this study is to determine the effectiveness of an NP-FEP in improving SE (primary outcome) and achieving goals related to cardiovascular risk (secondary outcome) for patients with cardiovascular disease.

Methods:
In June and July 2013, a total of 403 patients with cardiovascular disease in Shanghai were randomized into the intervention and control groups. Personalized end goals were established for improving cardiovascular risk for each patient. The control group received conventional follow-up education, whereas the intervention group was contacted by telephone 11 times over a 6-month period with staged goals developed based on SE theory. Self-efficacy scores and goals for reducing cardiovascular risk were assessed at baseline, at the end of the 6-month intervention, and 12 months after enrollment.

Results:
The SE scores in both groups increased at 6 months and decreased slightly at 12 months. The baseline SE scores were similar between the groups (P > .05), but the average SE scores were increased more for the intervention group than for the control group at 6 (P < .05) and 12 (P < .05) months. In addition, the final goal achievement rates for the intervention group were significantly higher than for the control group (P < .05). The difference between the 2 groups was reflected by differences in cardiac disease risk factors defined by the World Health Organization.

Conclusion:
The NP-FEP improved SE and facilitated achievement of goals related to risk factors in patients with cardiovascular disease for at least 1 year.
The Impact of Nurse Staffing on In-Hospital Mortality of Stroke Patients in Korea
Authors: Chung Wankyo , Sohn Min 
Published: May 2017

Background:
Stroke is one of the leading causes of death in Korea, and a well-qualified, adequate nursing force achieves better patient outcomes.

Study Purposes:
This study examined the association between nurse staffing and in-hospital mortality among stroke patients in a nationally representative sample.

Methods:
This cross-sectional retrospective study was conducted using 2009 National Health Insurance claims data of stroke patients admitted to variously sized Korean hospitals. The data included patient (individual and clinical) and hospital characteristics. Mortality was measured using crude in-hospital mortality rates; nurse staffing was expressed as number of registered nurses per 100 beds. Logistic regression was used to study the association between nurse staffing and patient mortality during hospitalization, after adjusting for related factors.

Results:
The data of 11 819 stroke inpatients from 615 hospitals were analyzed. Mean patient age was 66.9 ± 13.1 years, 47.5% were women, 77.4% were ischemic patients, and 20.3% underwent surgery. The crude in-hospital mortality rate was 5.5%. Nurse staffing was found to be negatively related to mortality (odds ratio, 0.988; 95% confidence interval, 0.977–0.999), after controlling for major confounders, such as comorbidities, physician-to-bed ratio, and medical costs.

Conclusion:
Policies to educate sufficient numbers of nurses and retain them in the field are warranted, especially because medical-cost containment has become a dominant concern in most countries. Further studies are needed to understand the mechanisms and other protective roles of nurse staffing to ensure long-term health outcomes after hospital discharge.
Variables Related to Communication About Prognosis Between Nurses and Patients at Heart Failure Clinics in Sweden and the Netherlands
Authors: van der Wal Martje H.L. , Hjelmfors Lisa , Mårtensson Jan , Friedrichsen Maria , Strömberg Anna , Jaarsma Tiny 
Published: May 2017

Background:
In contrast to recommendations in recent guidelines, prognosis is not optimally discussed with patients with heart failure (HF). Reasons for not doing so can be related to both patient and provider characteristics.

Purpose:
The purpose of the study was to explore which patient- and nurse-related variables influence discussing prognosis with patients at an HF clinic.

Method:
Data from a previous survey on attitudes and clinical practice of HF nurses on discussing prognosis that was conducted in Sweden and the Netherlands were combined with data from a registration on topics that nurses discussed with their patients during a prespecified week at the HF clinic. Multivariable logistic regression analysis was performed to assess which variables are related to discussing prognosis.

Results:
A total of 275 HF nurses (mean age, 49 years) and data of 1633 patients with HF (mean age, 71 years) were included in the study. Prognosis was discussed with 42% of all patients during the visit at the HF clinic. Patients with whom prognosis was discussed were more often in New York Heart Association classes III to IV (odds ratio [OR], 1.81; 95% confidence interval [CI], 1.44–2.26). Nurses discussing prognosis reported more knowledge on the topic (OR, 1.71; 95% CI, 1.36–2.16) and discussed more topics with the patient (OR, 1.27; 95% CI, 1.21–1.32). Dutch HF nurses were more likely to discuss prognosis compared with their Swedish colleagues (OR, 1.83; 95% CI, 1.43–2.33).

Conclusions:
Discussing prognosis with patients with HF by nurses at the HF clinic is related to the characteristics of patients and HF nurses. Future interventions to improve communications about prognosis therefore should have a broad approach.
The Monthly Cycle of Hypoglycemia
Authors: Basu Sanjay , Berkowitz Seth A. , Seligman Hilary 
Published: May 2017

Background:
Multipayer initiatives have sought to address social determinants of health, such as food insecurity, by linking primary care patients to social services. It remains unclear whether such social determinants contribute to avoidable short-term health care costs.

Objectives:
We sought to quantify costs and mitigating factors for the increased risk of hypoglycemia at the end of each month among low-income Americans, a phenomenon related to exhaustion of food budgets.

Research Design:
We used claims data on 595,770 commercially insured American adults aged 19 through 64 years old from 2004 through 2015 to estimate the risks and costs of emergency room visits and inpatient hospitalizations for hypoglycemia during the last week of each month versus prior weeks.

Results:
Although persons with household incomes greater than the national median did not experience a monthly cycle of hypoglycemia, those with incomes less than the national median had an odds ratio of 1.07 (95% confidence interval, 1.02–1.12; P=0.005) for emergency room visits or inpatient hospitalizations for hypoglycemia during the last week of each month, compared with earlier weeks. The risk of end-of-the-month hypoglycemia was mitigated to statistical insignificance during a period of increased federal nutrition program benefits from 2009 through 2013. Eliminating the monthly cycle of hypoglycemia among commercially insured nonelderly adults would be expected to avert $54.1 million per year (95% confidence interval, $0.8–$204.0) in emergency department and inpatient hospitalization costs.

Conclusions:
Addressing the end-of-the-month increase in hypoglycemia risk among lower-income populations may avert substantial costs from emergency department visits and inpatient hospitalizations.
Editorial boards of accounting journals: gender diversity and internationalisation
Authors: Dhanani Alpa , Jones Michael John 
Published: May 2017

PurposeEditorial boards of academic journals represent a key institutional mechanism in the governance and functioning of the academic community. Board members play an important role in knowledge production and development of the discipline. The purpose of this paper is to enquire into the diversity characteristics of boards of accounting journals.Design/methodology/approachDrawing on a diversity framework that distinguishes between societal diversity and value of diversity, the paper examines two board characteristics: gender diversity and internationalisation. Moreover, it examines the influence of three journal and two editor characteristics on board diversity and analyses trends over time.FindingsOn gender, overall board trends are consistent with societal diversity and value of diversity: boards reflect the gender profile of senior academics. Further, female representation on boards is broadly consistent across the different journal nationalities; has improved over time; has experienced a convergence in “gender sensitive” sub-disciplines; and is influenced by female editorship. However, inequities appear to be present at the highest level: women appear to be less well represented than men as editors and women also have a lower representation on boards of higher ranked journals than on those of lower ranked journals. On internationalisation, once again, overall trends broadly reflect societal diversity and value at diversity. However, international scholars are less well represented on 4* boards than on 2* and 3* boards and on US boards than on Australian and UK boards. Further, there are signs of weakening US dominance in non-US journals.Originality/valueDrawing on the diversity framework, this is the first study to comprehensively examine gender diversity and internationalisation of accounting boards.
An empirical analysis of user behaviour on multilingual information retrieval
Authors: Si Li , Pan Qiuyu , Zhuang Xiaozhe 
Published: May 2017

Purpose
This paper aims to understand user information behaviours when they perform multilingual information retrieval. It also offers reference for the development of multilingual information retrieval systems and relevant service platforms.

Design/methodology/approach
The authors designed an experiment on multilingual information retrieval with WorldWideScience, utilized Camtasia studio7 (a screen capturing and recording tool) to record overall operational processes of subjects and collected participants’ thought processes with think-aloud protocols. Meanwhile, a questionnaire survey and interviews were used to examine the subjects’ background information, their feelings for the experiment and their ideas about the experimental platform, respectively. Thirty-two valid data points were obtained by 41 subjects.

Findings
The users preferred their own language for retrieval. Most users from social science chose general search or advanced search freely according to the tasks. The majority of the participants selected key words directly from the tasks as search terms. Doctoral candidates were more likely to construct a search query with logic symbols. Translation tools were utilized for assisting retrieval and solving doubts of translation. When facing obstacles, users stayed on the original web page to explore continually, followed by back to homepage.

Originality/value
This paper provides a study of user behaviour through investigating how users behave on the whole process of retrieving multilingual information. The findings offer advice for optimizing the function of multilingual information retrieval systems and service platforms.
A cell-based smoothed point interpolation method (CS-PIM) for 2D thermoelastic problems
Authors: Liu Yijun , Zhang Guiyong , Lu Huan , Zong Zhi 
Published: May 2017

PurposeDue to the strong reliance on element quality, there exist some inherent shortcomings of the traditional finite element method (FEM). The model of FEM behaves overly stiff, and the solutions of automated generated linear elements are generally of poor accuracy about especially gradient results. The proposed cell-based smoothed point interpolation method (CS-PIM) aims to improve the results accuracy of the thermoelastic problems via properly softening the overly-stiff stiffness.Design/methodology/approachThis novel approach is based on the newly developed G space and weakened weak (w2) formulation, and of which shape functions are created using the point interpolation method and the cell-based gradient smoothing operation is conducted based on the linear triangular background cells.FindingsOwing to the property of softened stiffness, the present method can generally achieve better accuracy and higher convergence results (especially for the temperature gradient and thermal stress solutions) than the FEM does by using the simplest linear triangular background cells, which has been examined by extensive numerical studies.Practical implicationsThe CS-PIM is capable of producing more accurate results of temperature gradients as well as thermal stresses with the automated generated and unstructured background cells, which make it a better candidate for solving practical thermoelastic problems.Originality/valueIt is the first time that the novel CS-PIM was further developed for solving thermoelastic problems, which shows its tremendous potential for practical implications.
Surface temperature of electronic assemblies equipped with tilted and low-powered QFN64 subjected to free convection
Authors: Baïri Abderrahmane , Ortega Hermoso Clara , San Martén Ortega David , Baïri Iken , Peter Zsolt 
Published: May 2017

Purpose
This work deals with the case of the quad flat non-lead 64 (QFN64) electronic package generating a low power range ranging from 0.01 to 0.1W. It is installed on one side of a printed circuit board (PCB) that can be inclined relative to the horizontal plane with an angle varying between 0° and 90° (horizontal and vertical positions, respectively). The surface temperature of the electronic assembly is subjected to air natural convection.

Design/methodology/approach
Calculations are done by means of the finite volume method for many configurations obtained by varying the generated power and the inclination angle.

Findings
The distribution of the surface temperature is determined on all the assembly areas (QFN and PCB). The study shows that the thermal behaviour of the electronic device is influenced by the generated power and the inclination angle. The 3D numerical survey leads to correlations allowing calculation of the average surface temperature in any part of the assembly, according to the power generated by the QFN64 and the inclination angle.

Originality/value
The proposed accurate correlations are original and unpublished. They optimize the thermal design of the electronic QFN64 package, which is increasingly used in many engineering fields.