bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutrient Intake in Vietnamese Preschool and School-Aged Children is Not Adequate
Authors: Bao Khanh Le Nguyen , Burgers Minke R. , Huu Chinh Nguyen , Tuoc Bui Van , Dinh Dung Nguyen , Deurenberg Paul , Schaafsma Anne 
Published: March 2016

Background: The traditional Vietnamese diet carries the risk of micronutrient deficiencies, and a substantial part of children <11 years do not meet the Vietnamese recommended dietary allowance (RDA) for a range of nutrients. Dairy products are known for their high nutrient density and milk in particular for its provision of high-quality protein and relevant concentrations of calcium, magnesium, vitamin B2, vitamin B12, and pantothenic acid. Objective: The present study aimed to evaluate the contribution of dairy to the overall nutrient intakes in the diets of Vietnamese children and to gain insight into factors affecting dairy consumption. Methods: Food intake, including dairy, was assessed by a 24-hour recall in 2811 Vietnamese children clustered into 4 age-groups: 1.0 to 2.9, 3.0 to 5.9, 6.0 to 8.9, and 9.0 to 11.9 years, and dairy was categorized into 6 product groups based on available information in the Vietnamese food composition table. Results: Higher dairy intake was associated with significantly higher intakes (in % estimated average requirement and %RDA) of all assessed nutrients, and largest effects and strongest associations were found for vitamin B2, calcium, vitamin D, fat, vitamin B1, protein, vitamin A, and zinc. Age, area of residence, and wealth status influenced the consumption of dairy products. Furthermore, age also influenced nutrient intake adequacy, which was generally lower at older age, especially after the age of 6 years. Conclusion: The nutrient composition of the diet in especially Vietnamese school-aged children requires attention, and (fortified) dairy can play an important role in this.
Pregnant Women Diet Quality and Its Sociodemographic Determinants in Southwestern Bangladesh
Authors: Shamim Abu Ahmed , Mashreky Saidur Rahman , Ferdous Tarana , Tegenfeldt Kathrin , Roy Sumitro , Rahman A. K. M. Fazlur , Rashid Iftekhar , Haque Raisul , Rahman Zakia , Hossen Kabir , Siddiquee Saydur Rahman , Rahman Mosiqure , Sanghvi Tina G. , Shaheen Nazma 
Published: March 2016

Background: Diet diversity of pregnant women is associated with nutrition sufficiency, micronutrient adequacy, and pregnancy outcomes. However, the sociodemographic determinants of diet diversity among pregnant women in low-income countries are not well studied. Objective: The analysis was undertaken to study the determinants of high dietary diversity and consumption of micronutrient-rich foods by pregnant women from rural Bangladesh. Methods: Pregnant women (508) were randomly selected from southwestern Bangladesh and interviewed to collect data about diet and sociodemographic characteristics. A 24-hour recall was used to collect information about diet. Diet diversity score was calculated for 9 major food groups. All analyses were conducted using STATA SE 12. Result: The overall mean diet diversity score was low at 4.28 and was significantly high among pregnant women who have higher educational achievement, whose husbands’ occupation was business, who live in households of 4 or more family members, and who were dwelling in a house with more than 1 room. Highest gap on knowledge and consumption was reported for 3 food groups including dairy foods, eggs, and dark green leafy vegetables. Consumption of dairy and eggs was lower among women from low socioeconomic status, but no significant association was found between sociodemographic characteristics and consumption of leafy vegetables. Conclusion: Our analysis has shown that diet quality of pregnant women was poor and intake of micronutrient-rich foods was low despite having knowledge about the importance of these foods, underscoring the need for promoting the diet quality in developing countries through behavior change communication programs.
Percutaneous access for endovascular aortic aneurysm repair: A systematic review and meta-analysis
Authors: Hajibandeh Shahin , Hajibandeh Shahab , Antoniou Stavros A , Child Emma , Torella Francesco , Antoniou George A 
Published: March 2016

Purpose Our objective was to undertake a comprehensive review of the literature and conduct an analysis of the outcomes of percutaneous endovascular aneurysm repair. Methods MEDLINE; EMBASE; CINAHL; CENTRAL; the World Health Organization International Clinical Trials Registry; ClinicalTrials.gov; and ISRCTN Register, and bibliographic reference lists were searched to identify all studies providing comparative outcomes of the percutaneous technique for endovascular aneurysm repair. Success rate and access-related complications were defined as the primary outcome parameters. Combined overall effect sizes were calculated using fixed effect or random effects models. We conducted a network meta-analysis of different techniques for femoral access applying multivariate meta-analysis assuming consistency. Findings Three randomised controlled trials and 18 observational studies were identified. Percutaneous access was associated with a lower frequency of groin infection ( p < 0.0001) and lymphocele ( p = 0.007), and a shorter procedure time ( p < 0.0001) and hospital length of stay ( p = 0.03) compared with open surgical access. Moreover, percutaneous endovascular aneurysm repair did not increase the risk of haematoma, pseudoaneurysm, and arterial thrombosis or dissection. Conclusion Percutaneous access demonstrates advantages over conventional surgical exposure for endovascular aneurysm repair, as indicated by access-related complications and hospital length of stay. Further research is required to define its impact on resource utilization, cost-effectiveness and quality of life.
Differential diagnosis of solid pancreatic masses: contrast‐enhanced harmonic (CEH‐EUS), quantitative‐elastography (QE‐EUS), or both?
Authors: Iglesias‐Garcia Julio , Lindkvist Björn , Lariño‐Noia Jose , Abdulkader‐Nallib Ihab , Dominguez‐Muñoz J Enrique 
Published: March 2016

BackgroundContrast‐enhanced harmonic endoscopic ultrasound (CEH‐EUS) and quantitative‐elastography endoscopic ultrasound (QE‐EUS) are considered useful tools for the evaluation of solid pancreatic tumors (SPT). The aim of our study was to evaluate the diagnostic accuracy of CEH‐EUS, QE‐EUS, and the combination of both for the differential diagnosis of SPT.MethodsSixty‐two consecutive patients (mean age 64.3 years, range 32–89 years, 44 male) who underwent EUS for the evaluation of SPT were prospectively included. EUS was performed with a linear Pentax‐EUS and a Hitachi‐Preirus processor. The mass (area A) and a reference area B were selected during QE‐EUS, and results expressed as B/A (strain ratio). A strain histogram of the mass was also evaluated. Microvascularization of the tumor was evaluated over 2 min during CEH‐EUS after intravenous injection of 4.8 mL SonoVue. Final diagnosis was based on histopathology of surgical specimens or EUS‐guided tissue acquisition and clinical follow‐up in non‐operated cases. Diagnostic accuracy of CEH‐EUS, QE‐EUS, and their combination was calculated.ResultsMedian size of the masses was 32 mm (range 12‐111). Final diagnosis was pancreatic adenocarcinoma (n  = 45), neuroendocrine tumor (n  = 3), inflammatory mass (n  = 10), pancreatic metastasis (n  = 2), autoimmune pancreatitis (n  = 1), and a mucinous cystadenocarcinoma (n  = 1). Overall accuracies for determination of malignancy using QE‐EUS, CEH‐EUS, their combination, and EUS‐guided tissue acquisition were 98.4% (95% confidence interval (CI): 91.4–99.7), 85.5% (95% CI: 74.7–92.2), 91.9% (95% CI: 82.5–96.5), and 91.5% (95% CI: 83.6–99.5), respectively.ConclusionThe combination of QE‐EUS and CEH‐EUS is a useful tool for the differential diagnosis of SPT, giving complementary information. However, this combination does not significantly increase the diagnostic accuracy of either of the techniques performed alone.
Neutrophil heterogeneity: implications for homeostasis and pathogenesis
Authors: Silvestre-Roig Carlos , Hidalgo Andres , Soehnlein Oliver 
Published: March 2016

AbstractNeutrophils are polymorphonuclear leukocytes of the phagocytic system that act as first line of host defense against invading pathogens but are also important mediators of inflammation-induced injury. In contrast to other members of the innate immune system, neutrophils are classically considered a homogenous population of terminally differentiated cells with a well-defined and highly conserved function. Indeed, their short lifespan, the absent proliferative capacity, their limited ability to produce large amounts of cytokines, and the failure to recirculate from the tissue to the bloodstream have sustained this idea. However, increasing evidence over the last decade has demonstrated an unexpected phenotypic heterogeneity and functional versatility of the neutrophil population. Far beyond their antimicrobial functions, neutrophils are emerging as decision-shapers during innate and adaptive immune responses. These emerging discoveries open a new door to understand the role of neutrophils during homeostatic but also pathogenic immune processes. Thus, this review details novel insights of neutrophil phenotypic and functional heterogeneity during homeostasis and disease.
VTD is superior to VCD prior to intensive therapy in multiple myeloma: results of the prospective IFM2013-04 trial
Authors: Moreau Philippe , Hulin Cyrille , Macro Margaret , Caillot Denis , Chaleteix Carine , Roussel Murielle , Garderet Laurent , Royer Bruno , Brechignac Sabine , Tiab Mourad , Puyade Mathieu , Escoffre Martine , Stoppa Anne-Marie , Facon Thierry , Pegourie Brigitte , Chaoui Driss , Jaccard Arnaud , Slama Borhane , Marit Gerald , Laribi Karim , Godmer Pascal , Luycx Odile , Eisenmann Jean-Claude , Allangba Olivier , Dib Mamoun , Araujo Carla , Fontan Jean , Belhadj Karim , Wetterwald Marc , Dorvaux Véronique , Fermand Jean-Paul , Rodon Philippe , Kolb Brigitte , Glaisner Sylvie , Malfuson Jean-Valere , Lenain Pascal , Biron Laetitia , Planche Lucie , Caillon Helene , Avet-Loiseau Herve , Dejoie Thomas , Attal Michel 
Published: March 2016

Key Points
The overall response rate following 4 induction cycles of VTD prior to ASCT is higher than that of 4 cycles of VCD.
Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3
Authors: Glišić Sanja , Cavanaugh David P. , Chittur Krishnan K. , Sencanski Milan , Perovic Vladimir , Bojić Tijana 
Published: March 2016

Abstract
Background
The pathophysiological overlapping between Sjorgen’s Syndrome (SS) and HCV, presence of anti- muscarinic receptor type 3 (M3R) antibodies in SS, the role that M3R plays in the regulation of the heart rate, has led to the assumption that cardiovagal dysfunction in HCV patients is caused by anti-M3R antibodies elicited by HCV proteins or by their direct interaction with M3R.

Results
To identify HCV protein which possibly is crossreactive with M3R or which binds to this receptor, we performed the Informational Spectrum Method (ISM) analysis of the HCV proteome. This analysis revealed that NS5A protein represents the most probable interactor of M3R or that this viral protein could elicit antibodies which modulate function of this receptor. Further detailed structure/function analysis of NS5A and M3R performed by the ISM method extended with other Digital Signal processing (DSP) approaches revealed domains of these proteins which participate in their crossreactivity or in their direct interaction, representing promising diagnostic and therapeutic targets.

Conclusions
Application of the ISM with other compatible bioinformatics methods offers new perspectives for identifying diagnostic and therapeutic targets for complicated forms of HCV and other viral infections. We show how the electron-ion interaction potential (EIIP) amino-acid scale used in the ISM combined with a robust, high performance hydrophobicity scale can provide new insights for understanding protein structure/function and protein-protein interactions.
Retinoic acid receptor signaling preserves tendon stem cell characteristics and prevents spontaneous differentiation in vitro
Authors: Webb Stuart , Gabrelow Chase , Pierce James , Gibb Edwin , Elliott Jimmy 
Published: March 2016

Abstract
Background
Previous studies have reported that adult mesenchymal stem cells (MSCs) tend to gradually lose their stem cell characteristics in vitro when placed outside their niche environment. They subsequently undergo spontaneous differentiation towards mesenchymal lineages after only a few passages. We observed a similar phenomenon with adult tendon stem cells (TSCs) where expression of key tendon genes such as Scleraxis (Scx), are being repressed with time in culture. We hypothesized that an environment able to restore or maintain Scleraxis expression could be of therapeutic interest for in vitro use and tendon cell-based therapies.

Methods
TSCs were isolated from human cadaveric Achilles tendon and expanded for 4 passages. A high content imaging assay that monitored the induction of Scx protein nuclear localization was used to screen ~1000 known drugs.

Results
We identified retinoic acid receptor (RAR) agonists as potent inducers of nuclear Scx in the small molecule screen. The upregulation correlated with improved maintenance of tendon stem cell properties through inhibition of spontaneous differentiation rather than the anticipated induction of tenogenic differentiation. Our results suggest that histone epigenetic modifications by RAR are driving this effect which is not likely only dependent on Scleraxis nuclear binding but also mediated through other key genes involved in stem cell self-renewal and differentiation. Furthermore, we demonstrate that the effect of RAR compounds on TSCs is reversible by revealing their multi-lineage differentiation ability upon withdrawal of the compound.

Conclusion
Based on these findings, RAR agonists could provide a valid approach for maintaining TSC stemness during expansion in vitro, thus improving their regenerative potential for cell-based therapy.
Existence theorems for single-valued and set-valued mappings with w-distances in metric spaces
Authors: Kaneko Soh , Takahashi Wataru , Wen Ching-Feng , Yao Jen-Chih 
Published: March 2016

AbstractIn this paper, using the concept of w-distances, and we prove existence theorems for single-valued mappings and set-valued mappings in a complete metric space which generalize Takahashi, Wong, and Yao’s theorems.
[18F]Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET)/Computed Tomography (CT) in Suspected Recurrent Breast Cancer: A Prospective Comparative Study of Dual-Time-Point FDG-PET/CT, Contrast-Enhanced CT, and Bone Scintigraphy
Authors: Hildebrandt Malene Grubbe , Gerke Oke , Baun Christina , Falch Kirsten , Hansen Jeanette Ansholm , Farahani Ziba Ahangarani , Petersen Henrik , Larsen Lisbet Brønsro , Duvnjak Sandra , Buskevica Inguna , Bektas Selma , Søe Katrine , Jylling Anne Marie Bak , Ewertz Marianne , Alavi Abass , Høilund-Carlsen Poul Flemming 
Published: March 2016

Purpose To prospectively investigate the diagnostic accuracy of [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) with dual-time-point imaging, contrast-enhanced CT (ceCT), and bone scintigraphy (BS) in patients with suspected breast cancer recurrence. Patients and Methods One hundred women with suspected recurrence of breast cancer underwent 1-hour and 3-hour FDG-PET/CT, ceCT, and BS within approximately 10 days. The study was powered to estimate the precision of the individual imaging tests. Images were visually interpreted using a four-point assessment scale, and readers were blinded to other test results. The reference standard was biopsy along with treatment decisions and clinical follow-up (median, 17 months). Results FDG-PET/CT resulted in no false negatives and fewer false positives than the other imaging techniques. Accuracy of results were similar for 1-hour and 3-hour FDG-PET/CT. For distant recurrence, the area under the receiver operating curve was 0.99 (95% CI, 0.97 to 1) for FDG-PET/CT, 0.84 (95% CI, 0.73 to 0.94) for ceCT, and 0.86 (95% CI, 0.77 to 0.94) for the combined ceCT+BS. Of 100 patients, 22 (22%) were verified with distant recurrence, and 18 of these had bone involvement. Nineteen patients (19%) had local recurrence only. In exploratory analyses, diagnostic accuracy of FDG-PET/CT was better than ceCT alone or ceCT combined with BS in diagnosing distant, bone, and local recurrence, shown by a greater area under the receiver operating curve and higher sensitivity, specificity, and superior likelihood ratios. Conclusion FDG-PET/CT was accurate in diagnosing recurrence in breast cancer patients. It allowed for distant recurrence to be correctly ruled out and resulted in only a small number of false-positive cases. Exploratory findings suggest that FDG-PET/CT has greater accuracy than conventional imaging technologies in this patient group.
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein
Authors: Fang Shenying , Sui Dawen , Wang Yuling , Liu Huey , Chiang Yi-Ju , Ross Merrick I. , Gershenwald Jeffrey E. , Cormier Janice N. , Royal Richard E. , Lucci Anthony , Wargo Jennifer , Hu Mimi I. , Gardner Julie M. , Reveille John D. , Bassett Roland L. , Wei Qingyi , Amos Christopher I. , Lee Jeffrey E. 
Published: March 2016

PurposeTo evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.Materials and MethodsPlasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date of blood draw. The vitamin D level was considered sufficient if it was 30 to 100 ng/mL. Kaplan-Meier and Cox regression analyses were performed.ResultsThe median vitamin D level was 25.0 ng/mL. The median follow-up time was 7.1 years. A lower vitamin D was associated with the blood draw during fall/winter months (P < .001), older age (P = .001), increased CRP (P < .001), increased tumor thickness (P < .001), ulcerated tumor (P = .0105), and advanced melanoma stage (P = .0024). On univariate analysis, lower vitamin D was associated with poorer overall (OS; P < .001), melanoma-specific survival (MSS; P = .0025), and disease-free survival (DFS; P = .0466). The effect of vitamin D on these outcome measures persisted after adjustment for CRP and other covariates. Multivariable hazards ratios per unit decrease of vitamin D were 1.02 for OS (95% CI, 1.01 to 1.04; P = .0051), 1.02 for MSS (95% CI, 1.00 to 1.04; P = .048), and 1.02 for DFS (95% CI, 1.00 to 1.04; P = .0427).ConclusionLower vitamin D levels in patients with melanoma were associated with poorer outcomes. Although lower vitamin D was strongly associated with higher CRP, the associations of lower vitamin D with poorer OS, MSS, and DFS were independent of this association. Investigation of mechanisms responsible for these associations may be of value to patients with melanoma.
Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency
Authors: Bouffet Eric , Larouche Valérie , Campbell Brittany B. , Merico Daniele , de Borja Richard , Aronson Melyssa , Durno Carol , Krueger Joerg , Cabric Vanja , Ramaswamy Vijay , Zhukova Nataliya , Mason Gary , Farah Roula , Afzal Samina , Yalon Michal , Rechavi Gideon , Magimairajan Vanan , Walsh Michael F. , Constantini Shlomi , Dvir Rina , Elhasid Ronit , Reddy Alyssa , Osborn Michael , Sullivan Michael , Hansford Jordan , Dodgshun Andrew , Klauber-Demore Nancy , Peterson Lindsay , Patel Sunil , Lindhorst Scott , Atkinson Jeffrey , Cohen Zane , Laframboise Rachel , Dirks Peter , Taylor Michael , Malkin David , Albrecht Steffen , Dudley Roy W.R. , Jabado Nada , Hawkins Cynthia E. , Shlien Adam , Tabori Uri 
Published: March 2016

Purpose Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic mismatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome often resulting in GBM characterized by a high mutational burden. Evidence suggests that high mutation and neoantigen loads are associated with response to immune checkpoint inhibition. Patients and Methods We performed exome sequencing and neoantigen prediction on 37 bMMRD cancers and compared them with childhood and adult brain neoplasms. Neoantigen prediction bMMRD GBM was compared with responsive adult cancers from multiple tissues. Two siblings with recurrent multifocal bMMRD GBM were treated with the immune checkpoint inhibitor nivolumab. Results All malignant tumors (n = 32) were hypermutant. Although bMMRD brain tumors had the highest mutational load because of secondary polymerase mutations (mean, 17,740 ± standard deviation, 7,703), all other high-grade tumors were hypermutant (mean, 1,589 ± standard deviation, 1,043), similar to other cancers that responded favorably to immune checkpoint inhibitors. bMMRD GBM had a significantly higher mutational load than sporadic pediatric and adult gliomas and all other brain tumors (P < .001). bMMRD GBM harbored mean neoantigen loads seven to 16 times higher than those in immunoresponsive melanomas, lung cancers, or microsatellite-unstable GI cancers (P < .001). On the basis of these preclinical data, we treated two bMMRD siblings with recurrent multifocal GBM with the anti–programmed death-1 inhibitor nivolumab, which resulted in clinically significant responses and a profound radiologic response. Conclusion This report of initial and durable responses of recurrent GBM to immune checkpoint inhibition may have implications for GBM in general and other hypermutant cancers arising from primary (genetic predisposition) or secondary MMRD.
Optimal Depth for Nasopharyngeal Temperature Probe Positioning
Authors: Wang Mi , Singh Asha , Qureshi Hashim , Leone Alexander , Mascha Edward J. , Sessler Daniel I. 
Published: March 2016

BACKGROUND:
The nasopharynx is considered 1 of the 4 generally reliable core temperature measurement sites. But curiously, there is no consensus on how far past the nares to insert the probe. Insertion depth is likely to influence the accuracy of nasopharyngeal temperature measurements because probes near the nares will be cooled by ambient air; similarly, probes inserted too far may approach the airway and be cooled by ventilation gases. We thus determined the range of nasopharyngeal probe insertion depths that best approximate reference core temperature measured in the distal esophagus.

METHODS:
In 36 adults undergoing noncardiac surgery with endotracheal intubation, we inserted a nasopharyngeal thermometer 20 cm past the nares and an esophageal temperature probe 40 cm from the incisors. The nasopharyngeal probe was withdrawn sequentially 2 cm at a time at 5-minute intervals. Pairs of nasopharyngeal and reference distal esophageal temperatures were then compared and summarized by Bland and Altman methods.

RESULTS:
All nasopharyngeal probe insertion depths between 10 and 20 cm past the nares provided temperatures similar to reference distal esophageal temperatures. At those depths, the bias was typically approximately −0.1°C, with SD of approximately ±0.15°C; the limits of agreement thus were easily within our a priori specified clinically acceptable range of −0.5°C and 0.5°C.

CONCLUSIONS:
Any nasopharyngeal probe insertion depth between 10 and 20 cm well represents core temperature in adults having noncardiac surgery.