bluuebunny/crossref_metadata_2025_split huggingface dataset:
Algoplus performance to detect pain in depressed and/or demented old patients
Authors: Bonin‐Guillaume S. , Jouve E. , Lauretta R. , Nalin C. , Truillet R. , Capriz F. , Rat P. 
Published: February 2016

AbstractBackgroundAlgoplus detects acute pain in non‐verbal old patients (NVOP) with good psychometric properties. However, depression or dementia might modify the Algoplus score and/or item expression. Algoplus performances on demented and/or depressed old populations were tested.MethodsThis multicentre cross‐sectional study included patients ≥65 years old with or without pain assigned to depression, dementia, depression & dementia or control groups. Each group was subjected to the Numerical Rating Scale (NRS) and behavioural scales (Algoplus, Doloplus). Depression and/or dementia status was rated and confirmed by blinded experts. Algoplus psychometric properties tested were: discriminant validity, convergent validity, item analysis, sensitivity to change after pain treatment and threshold determination.ResultsThe analysis included 171 patients (mean age 82.3 ± 6.3 years). Patients with and without pain in each group were comparable for age in all subgroups, except the older dementia subgroup. The mean Algoplus score was significantly higher for patients with than without pain, regardless of group assignment (Wilcoxon signed‐rank test, p < 0.001). Algoplus and NRS or Doloplus had high convergent validity (respective Spearman correlation coefficients 0.79 and 0.87). The mean Algoplus score decreased significantly after starting pain management, regardless of group assignment. Some behaviours (i.e. “look”) occurred more often in depressed patients, even those without pain. A threshold of 2 yielded respective sensitivity and specificity values of 95% and 96% for dementia patients, 62% and 79% for depressed patients, 96% and 71% for dementia & depressed patients, and 80% and 100% for controls.ConclusionAlgoplus accurately detected pain in depressed and/or dementia patients; and was sensitive to change after pain treatment.What does this study add?Algoplus accurately detects pain in depressed and/or demented patients.A cut‐off score of 2 accurately detects the need for pain management in these populations.Algoplus is sensitive to change after treating pain.
Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type
Authors: Di Stefano G. , Celletti C. , Baron R. , Castori M. , Di Franco M. , La Cesa S. , Leone C. , Pepe A. , Cruccu G. , Truini A. , Camerota F. 
Published: February 2016

AbstractBackgroundPatients with joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type (JHS/EDS‐HT) commonly suffer from pain. How this hereditary connective tissue disorder causes pain remains unclear although previous studies suggested it shares similar mechanisms with neuropathic pain and fibromyalgia.MethodsIn this prospective study seeking information on the mechanisms underlying pain in patients with JHS/EDS‐HT, we enrolled 27 consecutive patients with this connective tissue disorder. Patients underwent a detailed clinical examination, including the neuropathic pain questionnaire DN4 and the fibromyalgia rapid screening tool. As quantitative sensory testing methods, we included thermal‐pain perceptive thresholds and the wind‐up ratio and recorded a standard nerve conduction study to assess non‐nociceptive fibres and laser‐evoked potentials, assessing nociceptive fibres.ResultsClinical examination and diagnostic tests disclosed no somatosensory nervous system damage. Conversely, most patients suffered from widespread pain, the fibromyalgia rapid screening tool elicited positive findings, and quantitative sensory testing showed lowered cold and heat pain thresholds and an increased wind‐up ratio.ConclusionsWhile the lack of somatosensory nervous system damage is incompatible with neuropathic pain as the mechanism underlying pain in JHS/EDS‐HT, the lowered cold and heat pain thresholds and increased wind‐up ratio imply that pain in JHS/EDS‐HT might arise through central sensitization. Hence, this connective tissue disorder and fibromyalgia share similar pain mechanisms.What does this study add?In patients with JHS/EDS‐HT, the persistent nociceptive input due to joint abnormalities probably triggers central sensitization in the dorsal horn neurons and causes widespread pain.
Primary sensory and motor cortex function in response to acute muscle pain: A systematic review and meta‐analysis
Authors: Burns E. , Chipchase L.S. , Schabrun S.M. 
Published: February 2016

AbstractAcute muscle pain has both motor and sensory consequences, yet the effect of muscle pain on the primary sensory (S1) and motor (M1) cortices has yet to be systematically evaluated. Here we aimed to determine the strength of the evidence for (1) altered activation of S1/M1 during and after pain, (2) the temporal profile of any change in activation and (3) the relationship between S1/M1 activity and the symptoms of pain. In September 2015, five electronic databases were systematically searched for neuroimaging and electrophysiological studies investigating the effect of acute experimental muscle pain on S1/M1 in healthy volunteers. Demographic data, methodological characteristics and primary outcomes for each study were extracted for critical appraisal. Meta‐analyses were performed where appropriate. Twenty‐five studies satisfied the inclusion criteria. There was consistent evidence from fMRI for increased S1 activation in the contralateral hemisphere during pain, but insufficient evidence to determine the effect at M1. Meta‐analyses of TMS and EEG data revealed moderate to strong evidence of reduced S1 and corticomotor excitability during and following the resolution of muscle pain. A comprehensive understanding of the temporal profile of altered activity in S1/M1, and the relationship to symptoms of pain, is hampered by differences in methodological design, pain modality and pain severity between studies. Overall, the findings of this review indicate reduced S1 and corticomotor activity during and after resolution of acute muscle pain, mechanisms that could plausibly underpin altered sensorimotor function in pain.What does this review add?We provide the first systematic evaluation of the primary sensory (S1) and motor (M1) cortex response to acute experimental muscle pain in healthy volunteers. We present evidence from a range of methodologies to provide a comprehensive understanding of the effect of pain on S1/M1. Through meta‐analyses we evaluate the strength of evidence concerning the direction and temporal profile of the S1/M1 response to acute muscle pain.
Development of an Electrochemical Biosensor for the Rapid Detection of Cholera Toxin Based on Air Stable Lipid Films with Incorporated Ganglioside GM1 Using Graphene Electrodes
Authors: Karapetis Stephanos , Nikoleli Georgia‐Paraskevi , Siontorou Christina G. , Nikolelis Dimitrios P. , Tzamtzis Nikolaos , Psaroudakis Nikolas 
Published: February 2016

AbstractThe present work describes a miniaturized potentiometric cholera toxin sensor on graphene nanosheets with incorporated lipid films. Ganglioside GM1, the natural cholera toxin receptor, immobilized on the stabilized lipid films, provided adequate selectivity for detection over a wide range of toxin concentrations, fast response time of ca. 5 min, and detection limit of 1 nM. The proposed sensor is easy to construct and exhibits good reproducibility, reusability, selectivity, long shelf life and high sensitivity of ca. 60 mV/decade of toxin concentration. The method was implemented and validated in lake water samples. This novel ultrathin film technology is currently adapted to the rapid detection of other toxins that could be used in bioterrorism.
Impact of hazard‐consistent ground motion duration in structural collapse risk assessment
Authors: Chandramohan Reagan , Baker Jack W. , Deierlein Gregory G. 
Published: February 2016

SummaryThis study evaluates the effect of considering ground motion duration when selecting hazard‐consistent ground motions for structural collapse risk assessment. A procedure to compute source‐specific probability distributions of the durations of ground motions anticipated at a site, based on the generalized conditional intensity measure framework, is developed. Targets are computed for three sites in Western USA, located in distinct tectonic settings: Seattle, Eugene, and San Francisco. The effect of considering duration when estimating the collapse risk of a ductile reinforced concrete moment frame building, designed for a site in Seattle, is quantified by conducting multiple stripe analyses using groups of ground motions selected using different procedures. The mean annual frequency of collapse (λcollapse) in Seattle is found to be underestimated by 29% when using typical‐duration ground motions from the PEER NGA‐West2 database. The effect of duration is even more important in sites like Eugene (λcollapse underestimated by 59%), where the seismic hazard is dominated by large magnitude interface earthquakes, and less important in sites like San Francisco (λcollapse underestimated by 7%), where the seismic hazard is dominated by crustal earthquakes. Ground motion selection procedures that employ causal parameters like magnitude, distance, and Vs30 as surrogates for ground motion duration are also evaluated. These procedures are found to produce poor fits to the duration and response spectrum targets because of the limited number of records that satisfy typical constraints imposed on the ranges of the causal parameters. As a consequence, ground motions selected based on causal parameters are found to overestimate λcollapse by 53%. Copyright © 2016 John Wiley & Sons, Ltd.
Seismic response estimation method for earthquake‐damaged RC buildings
Authors: Choi Ho , Sanada Yasushi , Kashiwa Hisatoshi , Watanabe Yasuhiro , Tanjung Jafril , Jiang Huanjun 
Published: February 2016

SummaryThis study proposes a procedure for identifying spectral response curves for earthquake‐damaged areas in developing countries without seismic records. An earthquake‐damaged reinforced concrete building located in Padang, Indonesia was selected to illustrate the identification of the maximum seismic response during the 2009 West Sumatra earthquake. This paper summarizes the damage incurred by the building; the majority of the damage was observed in the third story in the span direction. The damage was quantitatively evaluated using the damage index R according to the Japanese guidelines for post‐earthquake damage evaluation. The damage index was also applied to the proposed spectral response identification method. The seismic performance of the building was evaluated by a nonlinear static analysis. The analytical results reproduced a drift concentration in the third story. The R‐index decreased with an increase in the story drift, which provided an estimation of the maximum response of the building during the earthquake. The estimation was verified via an earthquake response analysis of the building using ground acceleration data, which were simulated based on acceleration records of engineering bedrock that considered site amplification. The maximum response estimated by the R‐index was consistent with the maximum response obtained from the earthquake response analysis. Therefore, the proposed method enables the construction of spectral response curves by integrating the identification results for the maximum responses in a number of earthquake‐damaged buildings despite a lack of seismic records. Copyright © 2016 The Authors. Earthquake Engineering & Structural Dynamics published by John Wiley & Sons Ltd.
Family Functioning and Quality of Life among Families in Eating Disorders: A Comparison with Substance‐related Disorders and Healthy Controls
Authors: Anastasiadou Dimitra , Sepulveda Ana R. , Sánchez Julio César , Parks Melissa , Álvarez Tamara , Graell Montserrat 
Published: February 2016

AbstractThe aim of this study was to compare the family functioning of Spanish parents of patients with an eating disorder (ED) with that of carers of patients with substance‐related disorders (SRDs) and families of healthy controls (HC). This cross‐sectional study included 48 mothers and 45 fathers of 48 adolescent patients with an ED, 47 mothers and 37 fathers of 47 patients with an SRD and 66 mothers and 50 fathers of 68 HCs. Families of ED patients reported lower levels of criticism, symptom accommodation and negative caregiving experience than families of SRD patients. However, relatives of both ED and SRD patients reported similar levels of quality of life related to their mental health. Furthermore, families of HCs generally exhibited better scores on all scales assessing their caregiving experiences. Regarding gender differences, there was a tendency in mothers, primarily those from the ED group, to report more adverse experiences as caregivers compared with fathers. Symptoms characteristic to each disorder may be associated with differential patterns of family functioning and may require specifically tailored family interventions. Early family intervention in adolescence is crucial, as relatives' quality of life does not seem to have been badly affected at this point in the course of the illness. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
To what extent have changes in channel capacity contributed to flood hazard trends in England and Wales?
Authors: Slater Louise J. 
Published: February 2016

AbstractThe frequency of floods has been projected to increase across Europe in the coming decades due to extreme weather events. However, our understanding of how flood frequency is affected by geomorphic changes in river channel capacity remains limited. This paper seeks to quantify the influence of trends in channel capacity on flood hazards. Measuring and predicting the effect of geomorphic changes on freshwater flooding is essential to mitigate the potential effects of major floods through informed planning and response. Hydrometric records from 41 stream gauging stations were used to measure trends in the flood stage (i.e. water surface elevation) frequency above the 1% annual exceedance threshold. The hydrologic and geomorphic components of flood hazard were quantified separately to determine their contribution to the total trend in flood stage frequency. Trends in cross‐sectional flow area and mean flow velocity were also investigated at the same flood stage threshold. Results showed that a 10% decrease (or increase) in the channel capacity would result in an increase (or decrease) in the flood frequency of approximately 1.5 days per year on average across these 41 sites. Widespread increases in the flood hazard frequency were amplified through both hydrologic and geomorphic effects. These findings suggest that overlooking the potential influence of changing channel capacity on flooding may be hazardous. Better understanding and quantifying the influence of geomorphic trends on flood hazard will provide key insight for managers and engineers into the driving mechanisms of fluvial flooding over relatively short timescales. Copyright © 2016 John Wiley & Sons, Ltd.
Observations of coastal cliff base waves, sand levels, and cliff top shaking
Authors: Young Adam P. , Guza Robert T. , O'Reilly William C. , Burvingt Olivier , Flick Reinhard E. 
Published: February 2016

AbstractConcurrent observations of waves at the base of a southern California coastal cliff and seismic cliff motion were used to explore wave–cliff interaction and test proxies for wave forcing on coastal cliffs. Time series of waves and sand levels at the cliff base were extracted from pressure sensor observations programmatically and used to compute various wave impact metrics (e.g. significant cliff base wave height). Wave–cliff interaction was controlled by tide, incident waves, and beach sand levels, and varied from low tides with no wave–cliff impacts, to high tides with continuous wave–cliff interaction. Observed cliff base wave heights differed from standard Normal and Rayleigh distributions. Cliff base wave spectra levels were elevated at sea swell and infragravity frequencies. Coastal cliff top response to wave impacts was characterized using microseismic shaking in a frequency band (20–45 Hz) sensitive to wave breaking and cliff impacts. Response in the 20–45 Hz band was well correlated with wave–cliff impact metrics including cliff base significant wave height and hourly maximum water depth at the cliff base (r2 = 0.75). With site‐specific calibration relating wave impacts and shaking, and acceptable anthropogenic (traffic) noise levels, cliff top seismic observations are a viable proxy for cliff base wave conditions. The methods presented here are applicable to other coastal settings and can provide coastal managers with real time coastal conditions. Copyright © 2016 John Wiley & Sons, Ltd.
Biogas Catalytic Reforming Studies on Nickel‐Based Solid Oxide Fuel Cell Anodes
Authors: Johnson G. B. , Hjalmarsson P. , Norrman K. , Ozkan U. S. , Hagen A. 
Published: February 2016

AbstractHeterogeneous catalysis studies were conducted on two crushed solid oxide fuel cell (SOFC) anodes in fixed‐bed reactors. The baseline anode was Ni/ScYSZ (Ni/scandia and yttria stabilized zirconia), the other was Ni/ScYSZ modified with Pd/doped ceria (Ni/ScYSZ/Pd‐CGO). Three main types of experiments were performed to study catalytic activity and effect of sulfur poisoning: (i) CH4 and CO2 dissociation; (ii) biogas (60% CH4 and 40% CO2) temperature‐programmed reactions (TPRxn); and (iii) steady‐state biogas reforming reactions followed by postmortem catalyst characterization by temperature‐programmed oxidation and time‐of‐flight secondary ion mass spectrometry. Results showed that Ni/ScYSZ/Pd‐CGO was more active for catalytic dissociation of CH4 at 750 °C and subsequent reactivity of deposited carbonaceous species. Sulfur deactivated most catalytic reactions except CO2 dissociation at 750 °C. The presence of Pd‐CGO helped to mitigate sulfur deactivation effect; e.g. lowering the onset temperature (up to 190 °C) for CH4 conversion during temperature‐programmed reactions. Both Ni/ScYSZ and Ni/ScYSZ/Pd‐CGO anode catalysts were more active for dry reforming of biogas than they were for steam reforming. Deactivation of reforming activity by sulfur was much more severe under steam reforming conditions than dry reforming; a result of greater sulfur retention on the catalyst surface during steam reforming.
Pd‐W Alloy Electrocatalysts and Their Catalytic Property for Oxygen Reduction
Authors: Dai Y. , Yu P. , Huang Q. , Sun K. 
Published: February 2016

AbstractIn order to design Pt‐free efficient cathode catalyst and promote the commercialization of fuel cells, different atomic ratio of carbon‐supported Pd‐W alloy catalysts were developed for oxygen reduction reaction (ORR). X‐ray diffraction (XRD) results show the Pd‐W alloys have the similar lattice characteristics to pure Pd. Transmission electron microscopy (TEM) and energy‐dispersive X‐ray spectroscopy (EDS) results show that the Pd‐W alloys disperse on the surface of carbon support uniformly. The results of the electrochemical tests show that the Pd19W/C has two‐fold mass activity over Pd/C, which is hopeful for the application as low‐cost cathode catalyst.
Ketamine administration reduces amygdalo‐hippocampal reactivity to emotional stimulation
Authors: Scheidegger Milan , Henning Anke , Walter Martin , Lehmann Mick , Kraehenmann Rainer , Boeker Heinz , Seifritz Erich , Grimm Simone 
Published: February 2016

AbstractIncreased amygdala reactivity might lead to negative bias during emotional processing that can be reversed by antidepressant drug treatment. However, little is known on how N‐methyl‐d‐aspartate (NMDA) receptor antagonism with ketamine as a novel antidepressant drug target might modulate amygdala reactivity to emotional stimulation. Using functional magnetic resonance imaging (fMRI) and resting‐state fMRI (rsfMRI), we assessed amygdalo‐hippocampal reactivity at baseline and during pharmacological stimulation with ketamine (intravenous bolus of 0.12 mg/kg, followed by a continuous infusion of 0.25 mg/kg/h) in 23 healthy subjects that were presented with stimuli from the International Affective Picture System (IAPS). We found that ketamine reduced neural reactivity in the bilateral amygdalo‐hippocampal complex during emotional stimulation. Reduced amygdala reactivity to negative pictures was correlated to resting‐state connectivity to the pregenual anterior cingulate cortex. Interestingly, subjects experienced intensity of psychedelic alterations of consciousness during ketamine infusion predicted the reduction in neural responsivity to negative but not to positive or neutral stimuli. Our findings suggest that the pharmacological modulation of glutamate‐responsive cerebral circuits, which is associated with a shift in emotional bias and a reduction of amygdalo‐hippocampal reactivity to emotional stimuli, represents an early biomechanism to restore parts of the disrupted neurobehavioral homeostasis in MDD patients. Hum Brain Mapp 37:1941–1952, 2016. © 2016 Wiley Periodicals, Inc.
Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men
Authors: Borggrefe Jan , de Buhr Timm , Shrestha Smriti , Marshall Lynn M , Orwoll Eric , Peters Kathy , Black Dennis M , Glüer Claus C ,   for the Osteoporotic Fractures in Men (MrOS) Study Research Group
Published: February 2016

ABSTRACT

We investigated the associations of 3D geometric measures and volumetric bone mineral density (vBMD) of the proximal femur assessed by quantitative computed tomography (QCT) with hip fracture risk among elderly men. This study was a prospective case-cohort design nested within the Osteoporotic Fractures in Men Study (MrOS) cohort. QCT scans of 230 men (65 with confirmed hip fractures) were evaluated with Mindways' QCTPRO-BIT software. Measures that are indicative of bone strength for the femoral neck (FN) and for the trochanteric region (TR) were defined. Bending strength measures were estimated by minimum section modulus, buckling strength by buckling ratio, and a local thinning index (LTI). Integral and trabecular vBMD measures were also derived. Areal BMD (aBMD) of the total proximal femur from dual-energy X-ray absorptiometry (DXA) is presented for comparison. Associations of skeletal measures with incident hip fracture were estimated with hazard ratios (HR) per standard deviation and their 95% confidence intervals (CI) from Cox proportional hazard regression models with adjustment for age, body mass index (BMI), site, and aBMD. Men with hip fractures were older than men without fracture (77.1 ± 6.0 years versus 73.3 ± 5.7 years, p &lt; 0.01). Age, BMI, and site-adjusted HRs were significant for all measures except TR_LTI. Total femural BMD by DXA (HR = 4.9, 95% CI 2.5–9.9) and QCT (HR = 5.5, 95% CI 2.5–11.7) showed the strongest association followed by QCT FN integral vBMD (HR = 3.6, 95% CI 1.8–6.9). In models that additionally included aBMD, FN buckling ratio (HR = 1.9, 95% CI 1.1–3.2) and trabecular vBMD of the TR (HR = 2.0, 95% CI 1.2–3.4) remained associated with hip fracture risk, independent of aBMD. QCT-derived 3D geometric indices of instability of the proximal femur were significantly associated with incident hip fractures, independent of DXA aBMD. Buckling of the FN is a relevant failure mode not entirely captured by DXA. Further research to study these relationships in women is warranted. © 2016 American Society for Bone and Mineral Research.