bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Telemonitoring in Patients with Chronic Obstructive Pulmonary Disease in Taiwan-A Randomized Controlled Trial
Authors: Ho Te-Wei , Huang Chun-Ta , Chiu Herng-Chia , Ruan Sheng-Yuan , Tsai Yi-Ju , Yu Chong-Jen , Lai Feipei ,   The HINT Study Group, Lin Yu-Feng , Tsai Hung-Bin , Hsu Nin-Chieh , Tseng Chia-Lin , Shu Chin-Chung , Ko Wen-Je , Chen Jin-Shing 
Published: March 2016

AbstractChronic obstructive pulmonary disease (COPD) is the leading cause of death worldwide and poses a substantial economic and social burden. Telemonitoring has been proposed as a solution to this growing problem, but its impact on patient outcome is equivocal. This randomized controlled trial aimed to investigate effectiveness of telemonitoring in improving COPD patient outcome. In total, 106 subjects were randomly assigned to the telemonitoring (n = 53) or usual care (n = 53) group. During the two months following discharge, telemonitoring group patients had to report their symptoms daily using an electronic diary. The primary outcome measure was time to first re-admission for COPD exacerbation within six months of discharge. During the follow-up period, time to first re-admission for COPD exacerbation was significantly increased in the telemonitoring group than in the usual care group (p = 0.026). Telemonitoring was also associated with a reduced number of all-cause re-admissions (0.23 vs. 0.68/patient; p = 0.002) and emergency room visits (0.36 vs. 0.91/patient; p = 0.006). In conclusion, telemonitoring intervention was associated with improved outcomes among COPD patients admitted for exacerbation in a country characterized by a small territory and high accessibility to medical services. The findings are encouraging and add further support to implementation of telemonitoring as part of COPD care.
A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing
Authors: Woodruff Kristina , Maerkl Sebastian J. 
Published: March 2016

AbstractMammalian synthetic biology could be augmented through the development of high-throughput microfluidic systems that integrate cellular transfection, culturing, and imaging. We created a microfluidic chip that cultures cells and implements 280 independent transfections at up to 99% efficiency. The chip can perform co-transfections, in which the number of cells expressing each protein and the average protein expression level can be precisely tuned as a function of input DNA concentration and synthetic gene circuits can be optimized on chip. We co-transfected four plasmids to test a histidine kinase signaling pathway and mapped the dose dependence of this network on the level of one of its constituents. The chip is readily integrated with high-content imaging, enabling the evaluation of cellular behavior and protein expression dynamics over time. These features make the transfection chip applicable to high-throughput mammalian protein and synthetic biology studies.
Pediatric Feeding in Infants With Pierre Robin Sequence Following Mandibular Distraction Osteogenesis
Authors: Mabry Kelly 
Published: March 2016

Pierre Robin sequence (PRS) causes anomalies that can include micrognathia, cleft palate, and glossoptosis. At birth, infants typically present with a small mandible (micrognathia) which displaces the tongue posteriorly and causes breathing difficulties due to airway obstruction. A large, U-shaped cleft palate is often associated with this condition and the combined phenotype can be seen in isolation or in conjunction with a syndrome. In the neonatal period, management of PRS focuses on airway obstruction and feeding through conservative positioning techniques that are often successful. However, infants that do not respond to conservative measures require surgical intervention such as tongue-lip adhesion, tracheostomy, or mandibular distraction osteogenesis (MDO) to manage their airway. While each of these surgical procedures have been used effectively, the process of MDO has become the definitive technique to surgically correct the airway obstruction in PRS by lengthening the mandible, which also brings the tongue forward and out of the airway.
Feeding intervention is directly related to the resolution of micrognathia which in turn advances the tongue base anteriorly, resolving the glossoptosis and airway obstruction. The infant's feeding experience, including pre-surgery and post-surgery considerations, are discussed.
Emerging Scientist: Examining Exercise-Based Therapies for Voice and Swallow Disorders With a Neuroplastic Eye
Authors: Schaser Allison J. 
Published: March 2016

Exercise-based therapies are currently used to treat voice and swallow disorders without a clear understanding of the mechanisms that alter the cranial neuromuscular system. The recent application of principles of neuroplasticity to rehabilitation has revolutionized how we think about treatment, highlighting the need for change in both behavior and neural substrates to create lasting benefits. It is difficult, however, to study neural substrates in human patients while controlling for factors that may influence plasticity, such as genetic and environmental differences. The use of a rat model allows these controls. My research aims to further our understanding of the neuroplastic potential of exercise in the cranial sensorimotor system with the ultimate long-term and future goal of guiding care of individuals with voice and swallow problems.
This work is significant because it examines the neuroplastic potential of exercise in the cranial sensorimotor system in both muscle and the central nervous system, along with the enduring effects of exercise with the long-term and future goal of using my results to guide current therapy timelines and protocols used in clinical populations with voice and swallow problems.
Net Economic Impacts of Recent Alaska Salmon Fishery Failures and Federal Relief
Authors: Seung Chang K. , Muse Ben , Waters Edward C. 
Published: March 2016

Abstract
Chinook Salmon Oncorhynchus tshawytscha runs in several areas of Alaska have recently fallen well below expected levels. Using a social accounting matrix (SAM) model, this study calculated the net regional impacts on employment and income of the commercial salmon fishery failures stemming from these small runs, taking into account the effects of the federal fishery disaster funds received by commercial fishermen. The results indicate that federal relief funds reduced the adverse economic impacts but that the distribution of these funds to permit owners alone was not sufficient to compensate for the losses by other stakeholders. This study also shows that a SAM-type model is useful for policymakers in deciding how federal funds should be distributed among the various stakeholders affected by fishery failures.
Received May 1, 2015; accepted November 8, 2015 Published online March 30, 2016
Acute citrulline‐malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players
Authors: Glenn Jordan M. , Gray Michelle , Jensen Austen , Stone Matthew S. , Vincenzo Jennifer L. 
Published: March 2016

AbstractCitrulline‐malate (CM) is a precursor to nitric‐oxide (NO) in the NO synthase (NOS) pathway and is suggested to increase exercise performance in younger individuals. With age, NO production decreases and augmented NO production may provide beneficial effects on sports performance among masters athletes (MAs). Purpose: To examine the effects of acute CM supplementation on grip strength, vertical power, and anaerobic cycling performance in female, MA tennis players. Methods: Seventeen female MA (51 ± 9 years) completed two double‐blind, randomized trials consuming CM (12 g dextrose + 8 g CM) and placebo (PLA) (12 g dextrose). One hour after consumption, subjects completed grip strength, vertical power, and Wingate anaerobic cycling assessments in respective order. Maximal and average grip strength, peak and average vertical power, anaerobic capacity, peak power, explosive power, and ability to sustain anaerobic power were calculated from the tests. Results: When consuming CM, participants exhibited greater maximal (p = .042) and average (p = .045) grip strength compared to PLA. No differences existed between trials for peak (p = .51) or average (p = .51) vertical power. For the Wingate, peak power (p < .001) and explosive power (p < .001) were significantly greater when consuming CM compared to PLA. For the ability to sustain power, a significant effect (p < .001) was observed for time within trials, but no significant differences were observed between trials regarding supplement consumed. Conclusions: These data suggest that consuming CM before competition has the potential to improve tennis match‐play performance in masters tennis athletes. However, this study utilized a controlled laboratory environment and research evaluating direct application to on‐court performance is warranted.
A proposed national research and development agenda for population health informatics: summary recommendations from a national expert workshop
Authors: Kharrazi Hadi , Lasser Elyse C , Yasnoff William A , Loonsk John , Advani Aneel , Lehmann Harold P , Chin David C , Weiner Jonathan P 
Published: March 2016

Objective: The Johns Hopkins Center for Population Health IT hosted a 1-day symposium sponsored by the National Library of Medicine to help develop a national research and development (R&D) agenda for the emerging field of population health informatics (PopHI).
Material and Methods: The symposium provided a venue for national experts to brainstorm, identify, discuss, and prioritize the top challenges and opportunities in the PopHI field, as well as R&D areas to address these.
Results: This manuscript summarizes the findings of the PopHI symposium. The symposium participants’ recommendations have been categorized into 13 overarching themes, including policy alignment, data governance, sustainability and incentives, and standards/interoperability.
Discussion: The proposed consensus-based national agenda for PopHI consisted of 18 priority recommendations grouped into 4 broad goals: (1) Developing a standardized collaborative framework and infrastructure, (2) Advancing technical tools and methods, (3) Developing a scientific evidence and knowledge base, and (4) Developing an appropriate framework for policy, privacy, and sustainability. There was a substantial amount of agreement between all the participants on the challenges and opportunities for PopHI as well as on the actions that needed to be taken to address these.
Conclusion: PopHI is a rapidly growing field that has emerged to address the population dimension of the Triple Aim. The proposed PopHI R&D agenda is comprehensive and timely, but should be considered only a starting-point, given that ongoing developments in health policy, population health management, and informatics are very dynamic, suggesting that the agenda will require constant monitoring and updating.
A meiotic drive element in the maize pathogenFusarium verticillioidesis located within a 102-kb region of chromosome V
Authors: Pyle Jay , Patel Tejas , Merril Brianna , Nsokoshi Chabu , McCall Morgan , Proctor Robert H. , Brown Daren W. , Hammond Thomas M. 
Published: March 2016

ABSTRACTFusarium verticillioidesis an agriculturally important fungus because of its association with maize and its propensity to contaminate grain with toxic compounds. Some isolates of the fungus harbor a meiotic drive element known as Sporekiller(SkK) that causes nearly all surviving meiotic progeny from anSkK× Spore killer-susceptible (SkS) cross to inherit theSkKallele.SkKhas been mapped to chromosome V but the genetic element responsible for meiotic drive and spore killing has yet to be identified. In this study, we used cleaved amplified polymorphic sequence markers to genotype individual progeny from anSkK×SkSmapping population. We also sequenced the genomes of three progeny from the mapping population to determine their single nucleotide polymorphisms. These techniques allowed us to refine the location ofSkKto a contiguous 102-kb region of chromosome V, herein referred to as theSklocus. Relative toSkSgenotypes,SkKgenotypes have one extra gene within this locus for a total of 42 genes. The additional gene inSkKgenotypes, named SKL1 forSpore Killer Locus 1, is the most highly expressed gene from theSklocus during early stages of sexual development. TheSklocus also has three hypervariable regions, the longest of which includesSKL1. The possibility thatSKL1, or another gene from theSklocus, is an essential component of meiotic drive and spore killing is discussed.
Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle
Authors: Mosadeghi Ruzbeh , Reichermeier Kurt M. , Winkler Martin , Schreiber Anne , Reitsma Justin M. , Zhang Yaru , Stengel Florian , Cao Junyue , Kim Minsoo , Sweredoski Michael J. , Hess Sonja , Leitner Alexander , Aebersold Ruedi , Peter Matthias , Deshaies Raymond J. , Enchev Radoslav I. 
Published: March 2016

AbstractThe COP9-Signalosome (CSN) regulates cullin–RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated. We combine structural and kinetic analyses to identify mechanisms that contribute to CSN activation and Nedd8 deconjugation. Both CSN and neddylated substrate undergo large conformational changes upon binding, with important roles played by the N-terminal domains of Csn2 and Csn4 and the RING domain of Rbx1 in enabling formation of a high affinity, fully active complex. The RING domain is crucial for deneddylation, and works in part through conformational changes involving insert-2 of Csn6. Nedd8 deconjugation and re-engagement of the active site zinc by the autoinhibitory Csn5 glutamate-104 diminish affinity for Cul1/Rbx1 by ~100-fold, resulting in its rapid ejection from the active site. Together, these mechanisms enable a dynamic deneddylation-disassembly cycle that promotes rapid remodeling of the cellular CRL network.
Genetic algorithm based fuzzy time series tourism demand forecast model
Authors: Sakhuja Sumit , Jain Vipul , Kumar Sameer , Chandra Charu , Ghildayal Sarit K 
Published: March 2016

Purpose
– Many studies have proposed variant fuzzy time series models for uncertain and vague data. The purpose of this paper is to adapt a fuzzy time series combined with genetic algorithm (GA) to forecast tourist arrivals in Taiwan.

Design/methodology/approach
– Different cases are studied to understand the effect of variation of fuzzy time series order, number of intervals and population size on the fitness function which decreases with increase in fuzzy time series order and number of fuzzy intervals, but do not have marginal effect due to change in population size.

Findings
– Results based on an example of forecasting Taiwan’s tourism demand was used to verify the efficacy of proposed model and confirmed its superiority to existing models providing solutions for different orders of fuzzy time series, number of intervals and population size with a smaller forecasting error as measured by root mean square error.

Originality/value
– This study provides a viable forecasting methodology, adapting a fuzzy time series combined with an evolutionary GA. The proposed hybridized framework of fuzzy time series and GA, where GA is used to calibrate fuzzy interval length, is flexible and replicable to many industrial situations.
Experientially educating future consultants: benefits, challenges, and constructs
Authors: Kupka Bernd , Westover Jonathan H , Workman Letty 
Published: March 2016

Purpose
– The purpose of this paper is to discuss experiential education as a way to develop future consultants in human resource management and marketing with the goal of developing consulting competence.

Design/methodology/approach
– This is a conceptual paper that proposes, outlines, and discusses a model, containing 11 dimensions of consulting competence.

Findings
– The conceptual model includes 11 building blocks: foreign language competence, non-verbal competence, perception of cultural distance, cultural self-awareness, knowledge, skills, motivation, effectiveness, appropriateness, contextual interaction patterns, and affinity. Considerations for each of these elements are introduced and discussed.

Practical implications
– This model and the explanation of its components should guide management and marketing educators in their efforts to build and develop experiential education programs of excellence.

Originality/value
– The model proposed and outline in this paper will assist institutions of higher education and faculty members to guide students in their development of a successful career in consulting.
How graduate students are supported in their teaching
Authors: Hoessler Carolyn , Stockley Denise 
Published: March 2016

Purpose– To provide a cohesive framework for understanding how supports co-occur and interact to impact graduate students’ teaching experiences, this paper systematizes the multi-layered context in which institutions, departments, faculty, peers, and individuals provide support. Previous studies on graduate students’ teaching focussed on specific programs, initially to describe them, and more recently to assess their outcomes. However, this piecemeal approach misses the complexity of graduate students’ contexts.Design/methodology/approach– Through a literature review of existing supports for graduate students’ teaching, the need for a contextual framework was clearly identified leading to its development and application to provide a cohesive categorization of supports.Findings– The review of existing literature identified graduate students’ supports and needs for support across all layers of their higher education context.Practical implications– This new framework offers a theoretical grounding for teasing apart the intertwined influences on graduate students’ teaching development. Higher education professionals seeking to demonstrate value for money may be disappointed by evaluations of formal programming revealing lower than expected changes in practice despite promising growth in graduate student’s conceptions of teaching. By considering additional influences and barriers to graduate students implementing newly learned teaching practices, potential conflicts may be revealed and addressed, and enabling influences identified and increased.Originality/value– Missing from existing literature is consideration of the multiple co-occurring influences on graduate students’ development, and an examination of how the various sources of support interact. This framework reveals potential interactions and contradictions that are important to consider when creating and evaluating supports for graduate students’ teaching.
The impact of taxes and regulations on firm births and deaths in state border counties
Authors: Crum Michael , Gohmann Stephan F 
Published: March 2016

Purpose– The purpose of this paper is to examine the influence of the institutional environment on firm birth and death rates. It is hypothesized that high taxation levels, large government size, high levels of unionization and high minimum wages will be associated with relatively low firm birth and death rates.Design/methodology/approach– This study makes use of a set of custom tabulations from the US Census Bureau that contain data on county-level firm births and deaths. To account for differences in state policies, matched contiguous counties located on state borders are used to calculate matched birth and death ratios.Findings– In the sample of eastern US state border counties, state taxation levels and minimum wages had no significant relationship with firm birth rates, but there was a negative relationship between state union densities and firm birth rates. Both state education and public welfare expenditures were marginally negatively related to firm birth rates. State public welfare expenditures were negatively related to firm death rates, while a marginally significant negative relationship between hospital/health expenditures and firm death rates was observed.Research limitations/implications– These results indicate that state government expenditures may have varying influences on firm birth and death rates, and that high union densities may deter new firm entry.Originality/value– This paper makes use of a county matching technique to help control for confounding variables, allowing for differences in state policies to be better accounted for.
Drivers of the accuracy of developers’ early stage cost estimates in residential construction
Authors: Lim Brendon , Nepal Madhav P. , Skitmore Martin , Xiong Bo 
Published: March 2016

Purpose
– Preliminary cost estimates for construction projects are often the basis of financial feasibility and budgeting decisions in the early stages of planning and for effective project control, monitoring and execution. The purpose of this paper is to identify and better understand the cost drivers and factors that contribute to the accuracy of estimates in residential construction projects from the developers’ perspective.

Design/methodology/approach
– The paper uses a literature review to determine the drivers that affect the accuracy of developers’ early stage cost estimates and the factors influencing the construction costs of residential construction projects. It used cost variance data and other supporting documentation collected from two case study projects in South East Queensland, Australia, along with semi-structured interviews conducted with the practitioners involved.

Findings
– It is found that many cost drivers or factors of cost uncertainty identified in the literature for large-scale projects are not as apparent and relevant for developers’ small-scale residential construction projects. Specifically, the certainty and completeness of project-specific information, suitability of historical cost data, contingency allowances, methods of estimating and the estimator’s level of experience significantly affect the accuracy of cost estimates. Developers of small-scale residential projects use pre-established and suitably priced bills of quantities as the prime estimating method, which is considered to be the most efficient and accurate method for standard house designs. However, this method needs to be backed with the expertise and experience of the estimator.

Originality/value
– There is a lack of research on the accuracy of developers’ early stage cost estimates and the relevance and applicability of cost drivers and factors in the residential construction projects. This research has practical significance for improving the accuracy of such preliminary cost estimates.