bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Robust Futures Survey: Analysis of New York City Frontline COVID-19 Healthcare Providers’ Wellbeing
Authors: Michaels-Strasser Susan , Hughes Rebekah , Hirsch-Moverman Yael 
Published: September 2024

Abstract

Background
The COVID-19 pandemic uncovered vulnerabilities of health systems in the United States. Healthcare providers in New York City experienced immense strain as case numbers rose quickly and severely early in the pandemic. Healthcare provider wellbeing is still not well understood, and gaps remain in understanding how wellbeing is affected by aspects of healthcare providers’ work.
Methods
A cross-sectional survey was conducted to assess the experiences of healthcare providers in New York City during the COVID-19 pandemic. The primary outcome, wellbeing, was assessed through instruments to measure COVID-19-specific anxiety and hope, while the main exposures included exposure to frontline work, amount of infection prevention and control training received, and amount of COVID-19-specific training received. Bivariate analyses and logistic regression were used to determine the main effects between covariates and outcomes.
Results
300 healthcare providers’ survey responses contributed to the analysis between February and March 2021. Most participants reported not having COVID-19-specific anxiety and high levels of hope. Those who reported living with a partner or family member during the pandemic had lower odds of experiencing COVID-19-specific anxiety compared with those living alone. Participants reporting moderate to high levels of infection prevention and control training received had higher odds of having high levels of hope compared with those receiving little to no infection prevention and control training.
Conclusions
Our findings provide targeted areas for practical interventions to improve healthcare provider support, especially during times of extreme stress on the healthcare system. Prioritization of health workforce safety through infection prevention training will allow for better overall pandemic preparedness and response and appears to improve hopefulness amongst healthcare providers.
Subcortical volumes, frontal cortical thickness, and pro-inflammatory cytokines in schizophrenia versus methamphetamine-induced psychosis
Authors: Blake Lauren , Williams Kimberley C. , Uhlmann Anne A. , Temmingh Henk , Burger Antoinette , Stein Dan J. , Naude Petrus J.W. 
Published: September 2024

Abstract

Schizophrenia is associated with alterations in subcortical volumes, cortical thickness and pro-inflammatory cytokines, that may correlate with clinical features. However, analogous work on methamphetamine-induced psychosis is lacking. This study examines subcortical volumes, frontal cortical thickness and pro-inflammatory cytokines in schizophrenia and methamphetamine-induced psychosis. Diagnosis and symptom severity were determined using the Structured Clinical Interview for Axis I Disorders and the Positive and Negative Syndrome Scale, respectively. Structural T1-weighted images were acquired using a 3-Tesla magnetic resonance imaging scanner. Serum peripheral cytokine concentrations were measured using a multiplex bead array. Schizophrenia (n = 36) and methamphetamine-induced psychosis (n = 27) participants showed decreased left amygdala volumes and frontal cortical thickness compared to healthy controls (n = 32). Schizophrenia participants had increased bilateral caudate, putamen, and nucleus accumbens volumes compared to controls, and greater right globus pallidus and nucleus accumbens volumes compared to the methamphetamine-induced psychosis group. No significant differences were found in cytokine levels between groups or associations with neuroimaging measures. The novel discovery of increased globus pallidus and nucleus accumbens volumes in schizophrenia group compared with methamphetamine-induced psychosis group may show important distinctions in the neurobiology between these conditions. Future investigations should employ larger sample sizes, incorporate longitudinal study designs, and integrate magnetic resonance spectroscopy which may show important neurometabolic signatures in these brain regions in methamphetamine-induced psychosis.
Association of psychological states, sleep patterns, vaccine, and pregnancy outcomes during the COVID-19 pandemic
Authors: Cai Shiqin , Shen Lixia , Ye Lisha , Zhang Shaofeng , Huang Jingwan , Zhu Caixia , Chen Haitian 
Published: September 2024

Abstract

Objective: This study investigates the relationship between the psychological state, sleep patterns, COVID-19 vaccine administration, and adverse pregnancy outcomes among pregnant women during the COVID-19 pandemic.
Methods: A prospective cohort study was conducted from April 2022 to November 2022 at the First Affiliated Hospital of Sun Yat-sen University, including 260 pregnant women meeting the inclusion criteria in the obstetric department. The Depression Anxiety Stress Scales (DASS-21) was used to assess depression, anxiety, and stress; the Impact of Event Scale-Revised (IES-R) was utilized to evaluate psychological stress related to COVID-19, and the Pittsburgh Sleep Quality Index (PSQI) was employed to measure sleep quality. Participants were grouped based on their scores or vaccination status, and the incidence of adverse pregnancy outcomes was compared among different groups.
Results: There was a statistically significant difference in the incidence of Postpartum Hemorrhage (PPH) among groups with varying degrees of depression (P < 0.05). However, no statistically significant differences were found in the incidence of adverse pregnancy outcomes among groups categorized by anxiety, stress, psychological stress, and sleep quality (P > 0.05). The comparison of COVID-19 vaccine administration showed no statistically significant differences in psychological status and adverse pregnancy outcomes (P > 0.05).
Conclusion: COVID-19-related depression may increase the risk of PPH. COVID-19 vaccination has no impact on pregnant women's mental health and adverse pregnancy outcomes. So, it can be considered a measure to prevent COVID-19 infection.
Not so different after all: a systematic review of rodent electroconvulsive therapy (ECT) models in translational chronic stress and depression research
Authors: von Mücke-Heim Iven-Alex , Kokolakis Evangelos , Gottschalk Michael , Kläffgen Sarah , Deussing Jan , Erhardt Angelika , Pape Julius 
Published: September 2024

Abstract

Electroconvulsive therapy (ECT) has been established as an efficacious and safe treatment for severe and/or treatment-resistant depression. However, despite decades of research, the exact biological signature of the mechanism of action of ECT has yet to be elucidated. As a translational tool, electroconvulsive stimulation (ECS), the preclinical rodent equivalent of ECT, offers the unique opportunity for further knowledge under controlled laboratory conditions. Here, for the first time, a systematic review following the PRISMA 2020 statement is presented, covering mouse and rat studies investigating the biobehavioral effects of ECS in chronic stress-based depression models. For this purpose, the PubMed and Web of Science databases (period: 01.01.2000 to 05.10.2023) were screened for different key word combinations (search terms: depression, chronic stress, electroconvulsive shock, rats, mice). The search yielded a total of 1067 records. After filtering, a total of 47 studies were included in this review (n = 7 mice, n = 40 rats). Previous studies have used 4 weeks of chronic unpredictable mild stress (CUMS) in adult male rats treated with bilateral ear clip ECS for 1 week (parameters: bidirectional square wave, 1.5 ms pulse width with 800 mA at 125 Hz, 1.2 sec stimulation duration, 120 mC charge) using no, propofol, or isoflurane anesthesia. The outcome measures were centered around anhedonia-related behaviors and hippocampal protein levels. Summary odds across different behavioral domains revealed antidepressive effects of ECS on anhedonia (14.5), locomotion (6.0), despair (4.3), and anxiety (2.0), accompanied by memory impairments (0.1). Risk of bias assessment suggested considerable risk, primarily due to unreported information on missing data and blinding. Based on our analysis of the evidence, methodological suggestions for future studies were developed. This review will help to further unlock the translational potential of the ECS to generate much needed insights into the molecular correlates of ECT, with special regard to treatment response and prognosis for depression patients.
Numerical Investigation of DBD Plasma actuator Using Phenomenological Model on the Dynamic Stall of Oscillating Airfoils at Low Reynolds Number
Authors: Elfeky Amr A. , Nasr Mohamed F. , Elshebiny Deyaa N. 
Published: September 2024

Abstract

Background: The ability to unconventionally flow control and enhancing aerodynamic efficiency has been improved in recent years by Dielectric barrier discharge (DBD) plasma actuators.
The purpose of this work is to investigate numerically the effect of (DBD) of the dynamic stall chronology of NACA 0012 oscillating airfoil at low Reynolds numbers at different values of applied Voltage (5-20 KV) and operating Frequencies (5-20 KHz) based on a phenomenological model.
Results: The results showed that, during the upstroke, an increase in the applied voltages at constant frequency, increases in the delay of the onset of the dynamic stall during the upstroke cycle and causes an early flow reattachment over the upper surface of the airfoil during the downstroke cycle compared to the baseline airfoil.
Conclusions: DBD produced a notable decreasing in the airfoil drag coefficient, increasing in lift coefficient and enhancing int the hysteresis effect among the oscillating cycle. However, when varying the operating frequencies at constant applied voltages, Insignificant improvement is observed.
Synthesis, Biological Properties, and Molecular Docking Studies of Pyrazolopyridine and Isoxazolopyridine Derivatives
Authors: Çelikoglu Umut , Gul Melek , Pelit Emel 
Published: September 2024

Abstract

Pyrazolopyridine and isoxazolopyridine derivatives were synthesized in a one-pot procedure from indan-1,3-dione, aromatic aldehydes, and 1,3-dimethyl-1H-pyrazol-5-amine or 5-amino-3-methylisoxazole in the presence of eco-friendly thiamine hydrochloride or phase transfer catalysts under sonication. Tetrabutylammonium bromide and tetraethylammonium tetrafluoroborate were found to be the most efficient catalysts, with 69–92% yields in short reaction times. The interaction of human serum albumin (HSA) with the synthesized pyrazolopyridine and isoxazolopyridine derivatives were studied by examining the fluorescence quenching once the compound-albumin complex is formed. The Stern-Volmer equation was used to evaluate the binding parameters. Compound 4g showed the highest fluorescence quenching efficiency. DFT and molecular docking studies were also carried out for the synthesized compounds. In our study, DFT-based calculations were used to investigate changes in electron density as visualized through counter maps, electrostatic potential surface maps, and frontier orbitals. PDB structures 3V03, 4OR0, and 8EC1, representing serum albumin transport proteins, were chosen for docking studies. Additionally, in silico investigations on the DNA/bovine serum albumin (BSA) binding activity of the compounds were conducted. The results exhibited that all the synthesized compounds inhibited different activities of the transferred albumin. Compound 4g exhibited the highest binding affinity towards 3V03 (A and B chains) with a binding energy of -8.50 kcal/mol.
Network pharmacology and molecular docking validation to explore the mechanism of fibrates regulating HIF-1A in the treatment of ischemic stroke
Authors: Yang Fengjiao , Yang Zixuan , Yan Ya , Gu Yun , Wang Pengyu , Wang Min , Chen Jianjie , Du Xiaoshan , Wang Guangming 
Published: September 2024

Abstract

Fibrates can prevent and treat ischemic stroke (IS), the occurrence and development of IS is closely related to hypoxia-inducible factor-1A (HIF-1A). However, the exact mechanism of fibrates regulating HIF-1A in the treatment of IS remains unclear. So network pharmacology and molecular docking were used to explore the mechanism of fibrates regulating HIF-1A in the treatment of IS in this study. Firstly, the structure of five fibrates were obtained by reviewing the literature and pharmacopoeia in this study, then the potential targets of fibrates, IS, HIF1A and HIF1A-related genes were obtained through various databases, their common targets were obtained through Venny 2.1.0. The PPI network diagram of fibrates, IS and HIF1A-related genes was plotted by String platform and Cytoscape3.8.1 software. The GO functional analysis results and KEGG pathways of fibrates, IS, HIF1A and HIF1A related genes were obtained by Metascape platform. Finally, the molecular docking of fibrates and HIF1A was performed by AutoDock software. The common targets of five fibrates and IS showed that only 3 fibrates contained HIF1A, GO functional analysis results, KEGG pathway analysis results and molecular docking results showed that fibrates can better regulate HIF1A to treat IS, its main action pathways are pathways in cancer, lipid and atherosclerosis and HIF-1 signaling pathway.
Bacteriophages improve the effectiveness of rhamnolipids in combating the biofilm of Candida albicans
Authors: Dusza Izabela , Jama Dominika , Skaradziński Grzegorz , Śliwka Paulina , Janek Tomasz , Skaradzińska Aneta 
Published: September 2024

Abstract

Biofilms produced by Candida albicans pose significant therapeutic challenges due to their resistance to conventional antimicrobials. In response, the need for the development of more potent strategies to combat such infections persists. Rhamnolipids (RLs) are biosurfactants with diverse antimicrobial properties. Bacteriophages (phages) are viruses that target specific bacterial strains, although recent studies have shown that they may also potentially affect biofilm formation by fungi and yeasts. This study investigated the combined antimicrobial effect of RLs and bacteriophages against C. albicans biofilms, focusing on their anti-adhesive and inhibitory effects on biofilm development. RT-PCR assays were used to analyze gene modulation in C. albicans biofilm formation in response to RLs and phage treatments. Additionally, hyphae formation in the presence of RLs, phages, and their mixtures was examined using fluorescence microscopy. The results demonstrated that the combined treatment of RLs and bacteriophages significantly reduced biofilm formation compared to individual treatments. The combination of 200 mg/L rhamnolipid with BF9 phage achieved a 94.8% decrease in biofilm formation. This synergy was confirmed in subsequent models, with rhamnolipids at the same concentration and phage LO5/1f nearly completely inhibiting biofilm formation (~ 96%). Gene expression analysis revealed a profound downregulation of key biofilm-associated genes when Candida cells were treated with 200 mg/L RLs and four phages (BF17, L05/1f, JG004, FD). The results of this study suggest the potential of combining RLs and bacteriophages in combating C. albicans biofilms, indicating a promising perspective for future therapeutic approaches, offering renewed hope in the battle against resilient infections.
A New Bayesian information criterion for high dimensional analysis
Authors: Chen Xin , Ma Xuejun , Zhao Peng , Zhou Wang 
Published: September 2024

Abstract

The significance of information criteria in model selection cannot be overstated, particularly within high-dimensional contexts. Various approaches have been developed to address this challenge, such as the High Dimensional Bayesian Information Criteria (HBIC) and the Extended Bayesian Information Criterion (EBIC), which have demonstrated utility in both theoretical frameworks and practical applications. Nevertheless, the delicate equilibrium between unknown parameters and model complexity warrants further investigation. In this study, we introduce a novel Bayesian information criterion capable of accommodating rapid covariate dimensionality expansion relative to sample size. We establish model selection consistency for both unpenalized and penalized estimators. Through extensive simulation analyses across commonly encountered models, our proposed criterion, termed Improved Bayesian Information Criterion (IBIC), exhibits significant enhancements over established competitors. Two gene associated real data analysis also demonstrate encouraging results. Furthermore, we show that IBIC can be applied to the generalized linear model in the same way as linear models.
Beidellite/montmorillonite-Phosphorus-based dendrimer organoclays :Structural features and chromate interaction analysis
Authors: Hajjaji Mohamed , beraa Abdellah , Laurent Régis , Caminade Anne-Marie 
Published: September 2024

Abstract

Organoclays are promising materials for pollutant retention, medicinal applications, and catalysis, making them an intriguing research topic. In this study, beidellite/montmorillonite and phosphorus-based dendrimer organoclays were prepared, and their microstructure was examined using X-ray diffraction, thermal analysis, Fourier-transform infrared spectroscopy, solid-state nuclear magnetic resonance spectroscopy, and high-resolution transmission electron microscopy. The study also investigated the dynamic and equilibrium adsorption of chromate onto these organoclays within a temperature range of 298-318°C. It was found that the formation of organoclays involved the substitution of Na+ ions with dendrimers, and the structural configuration depended on the dendrimer size. Additionally, chromate retention by the organoclays occurred rapidly, with the kinetics data fitting well to the pseudo-second-order equation, suggesting chemisorption as the primary adsorption mechanism. The adsorption kinetics were controlled by intragranular diffusion (diffusion coefficient ranging from 0.007 to 0.018 mmol.g⁻¹) and external diffusion (diffusion coefficient ranging from 0.011 to 0.06 min⁻¹). Thermodynamic data and adsorption isotherms modeling showed that chromate adsorption was spontaneous and endothermic, and the isotherms fitted well to the Temkin model. Chromate binding to the organoclay involved protonated amino groups of the dendrimer (first-generation), with an adsorption capacity of 15 mg of chromate per gram, slightly exceeding that of some other organoclays.
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation
Authors: Wang Deliang , Liu Ke 
Published: September 2024

Abstract

Background
In the quest to elucidate novel therapeutic strategies for myocardial injury, recent investigations have underscored the pivotal roles played by circulating extracellular vesicles (EVs) in intercellular communication.
Method
EVs were extracted from individuals who had experienced AMI-EVs and those who were N-EVs. To assess the impact of circulating EVs on cardiomyocyte and endothelial cell proliferation, apoptosis, migration, and tube formation, a range of in vitro assays such as CCK8, EdU assays, flow cytometry, wound healing assays and angiogenesis assays were conducted. Differentially expressed miRNAs in EVs were validated using microarray analysis and real-time PCR. Through bioinformatics analysis, ELAVL1 was identified as a potential downstream target of miR-133a-3p. This finding was further confirmed by conducting dual-luciferase reporter assay and RNA co-immunoprecipitation experiments. To investigate the regulatory effects of circulating EVs from various sources on myocardial injury and PANoptosis, an animal model of ischemia-reperfusion-induced myocardial injury was established.
Result
Our findings revealed that circulating EVs effectively deliver miR-133a-3p to target cells, where it binds to ELAVL1, leading to a decrease in NLRP3 mRNA stability. This reduction in NLRP3 mRNA stability subsequently inhibits the assembly of the PANoptosome, a multi-protein complex implicated in PANoptosis. As a result, we observed a significant mitigation of PANoptosis in our myocardial injury models, demonstrating the protective role of miR-133a-3p against excessive cell death.
Conclusion
The present study underscores the regulatory role of circulating EV-delivered miR-133a-3p in modulating PANoptosis through ELAVL1-mediated NLRP3 mRNA stabilization. This mechanism represents a potential therapeutic target for attenuating myocardial injury by suppressing PANoptosis.
Physical activity and its correlates among pregnant women from the French national cohort ELFE
Authors: Aubert Adrien M. , Charles Marie-Aline , Heude Barbara , Bernard Jonathan Y. , Dargent-Molina Patricia 
Published: September 2024

Abstract

Background
Most pregnant women do not reach the minimum recommended level of 150 min/week of moderate physical activity (MPA). Most previous studies of correlates focused on leisure time physical activity (LTPA) ignoring other domains of MPA (occupational, household/childcare, transportation). This article aims to estimate the proportion of French pregnant women meeting physical activity (PA) guidelines, and identify sociodemographic, and maternal health and behavioural correlates, whenever only LTPA or overall MPA is considered.
Methods
A total of 14,484 pregnant women included in 2011 in the French national ELFE birth cohort reported their PA during the last trimester of their pregnancy using the Pregnancy Physical Activity Questionnaire. Women spending ≥450 MET-min/week in MPA (i.e., ≥150 min/week in activities at ≥3 METs) were considered reaching recommended PA levels. Sociodemographic and maternal health and behavioural correlates associated, respectively, with meeting PA guidelines for LTPA and having a high overall MPA (defined as an overall MPA ≥70th percentile) were assessed by multivariable logistic regressions.
Results
Most of the pregnant women reported engaging in LTPA during the last three months of pregnancy (92.3%), with walking as main activity; however, about 28.0% of women met guidelines for LTPA. Adding other MPA (transportation, household/caregiving, occupational) drastically increased this estimate (up to 85.6%). Primiparity, higher education and income levels, and a higher number of prenatal classes attended were positively associated with meeting guidelines for LTPA, but negatively with having high overall MPA levels. Younger age was positively associated with high MPA whereas not working during the last trimester of pregnancy was negatively associated with high MPA. Pre-pregnancy overweight/obesity were negatively associated with meeting guidelines for LTPA. Being single was positively associated with both outcomes.
Conclusions
Most sociodemographic and maternal correlates examined had differing associations with engaging in sufficient LTPA or high overall MPA. In particular, associations with indicators of social vulnerability were in opposite directions. These results call for continuing efforts to promote PA during pregnancy while inviting to specify which activities (type/context) provide optimum health benefits.
Trial registration
Not applicable.