bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model
Authors: Gong Yu-Hang , Hua Nan , Zang Xuan , Huang Tao , He Ling 
Published: October 2017

Abstract

Objectives
The objective of this study was to evaluate whether melatonin could ameliorate cognitive function in Aβ1-42-induced mouse model and its underlying mechanisms.

Methods
Series behaviour tests were performed to demonstrate the amelioration of cognitive function of the Alzheimer's disease (AD) mice induced by Aβ1-42. Additionally, enzyme-linked immunosorbent assay was applied to detect the expression of Aβ1-42, BACE1 and p-tau protein in the brain of the AD mice. JC-1 was performed to investigate the role in alleviating mitochondrial damage by melatonin in vitro. Western blot was used to detect the expression of melatonin on apoptosis-related factors caspase-3 and Bcl-2, as well as the expressions of GSK-3β and PP2A to further determine the mechanisms of melatonin on the expression of p-tau protein.

Key findings
Melatonin significantly ameliorated the cognitive function and mitochondrial damage in AD mice, reduced the expression levels of GSK-3β, caspase-3, Aβ1-42, BACE1, p-tau protein and increased the expressions of PP2A and Bcl-2.

Conclusion
From the overall results, we concluded that melatonin alleviated the mitochondrial damage effectively and decreased the expressions of the p-tau and some key proteins of apoptosis, leading to the improvement of cognitive function of the mice induced by Aβ1-42.
An integrated community‐based outpatient therapeutic feeding programme for severe acute malnutrition in rural Southern Ethiopia: Recovery, fatality, and nutritional status after discharge
Authors: Tadesse Elazar , Worku Amare , Berhane Yemane , Ekström Eva‐Charlotte 
Published: October 2017

AbstractA scaled up and integrated outpatient therapeutic feeding programme (OTP) brings the treatment of severely malnourished children closer to the community. This study assessed recovery from severe acute malnutrition (SAM), fatality, and acute malnutrition up to 14 weeks after admission to a programme integrated in the primary health care system. In this cohort study, 1,048 children admitted to 94 OTPs in Southern Ethiopia were followed for 14 weeks. Independent anthropometric measurements and information on treatment outcome were collected at four home visits. Only 32.7% (248/759) of children with SAM on admission fulfilled the programme recovery criteria at the time of discharge (i.e., gained 15% in weight, or oedema, if present at admission, was resolved at discharge). Of all children admitted to the programme for whom nutritional assessment was done 14 weeks later, 34.6% (321/928) were severely malnourished, and 37.5% (348/928) were moderately malnourished; thus, 72.1% were acutely malnourished. Of the children, 27/982 (2.7%) had died by 14 weeks, of whom all but one had SAM on admission. Children with severe oedema on admission had the highest fatality rate (12.0%, 9/75). The median length of admission to the programme was 6.6 weeks (interquartile range: 5.3, 8.4 weeks). Despite children participating for the recommended duration of the programme, many children with SAM were discharged still acutely malnourished and without reaching programme criteria for recovery. For better outcome of OTP, constraints in service provision by the health system as well as challenges of service utilization by the beneficiaries should be identified and addressed.
On the Philosophy of Bitcoin/Blockchain Technology: Is it a Chaotic, Complex System?
Authors: Dos Santos Renato P. 
Published: October 2017

AbstractThe philosophy of blockchain technology is concerned, among other things, with blockchain ontology, how it might be characterised, how it is being created, implemented, and adopted, how it operates in the world, and how it evolves over time. This paper concentrates on whether Bitcoin/blockchain can be considered a complex system and, if so, whether it is a chaotic one. Beyond mere academic curiosity, a positive response would raise concerns about the likelihood of Bitcoin/blockchain entering a 2010‐Flash‐Crash‐type of chaotic regime, with catastrophic consequences for financial systems based on it. The paper starts by highlighting the relevant details of the Bitcoin/blockchain ecosystem formed by the blockchain itself, bitcoin end users (payers and payees), capital gains seekers, miners, full nodes maintainers, and developers, and their interactions. Then the Information Theory of Complex Systems is briefly discussed for later use. Finally, the blockchain is investigated with the help of Crutchfield's Statistical Complexity measure. The low non‐null statistical complexity value obtained suggests that the blockchain may be considered algorithmically complicated but hardly a complex system and unlikely to enter a chaotic regime.
Blockchain Identities: Notational Technologies for Control and Management of Abstracted Entities
Authors: Dupont Quinn 
Published: October 2017

AbstractThis paper argues that many so‐called digital technologies can be construed as notational technologies, explored through the example of Monegraph, an art and digital asset management platform built on top of the blockchain system originally developed for the cryptocurrency bitcoin. As the paper characterizes it, a notational technology is the performance of syntactic notation within a field of reference, a technologized version of what Nelson Goodman called a “notational system.” Notational technologies produce abstracted entities through positive and reliable, or constitutive, tests of socially acceptable meaning. Accordingly, this account deviates from typical narratives of blockchains (usually characterized as Turing or state machines), instead demonstrating that blockchain technologies are effective at managing digital assets because they produce abstracted identities through the performance of notation. Since notational technologies rely on configurations of socially acceptable meaning, this paper also provides a philosophical account of how blockchain technologies are socially embedded.
Philosophical Criteria in Whitehead and Rorty
Authors: Duvernoy Russell J. 
Published: October 2017

AbstractRorty's aversion to metaphysics is well known, so the extent of his early work on Whitehead might come as a surprise. This article examines the young Rorty's critical assessment of Whitehead to show how it demonstrates the consequences of diverging metaphilosophical orientations. It argues that Rorty's insistence on judging Whitehead's work through an exclusively epistemological frame causes him to miss its more radical existential and epistemic implications. After examining how Rorty and Whitehead operate with different cost‐benefit analyses as to the risks and benefits of speculative philosophy, it suggests that closer attention to the fuller stakes of Whitehead's project shows that his metaphysics are not opposed to the “poeticized” culture that Rorty calls for, one where the distinction between making and finding is no longer metaphysically foundational.
Ankyloglossia as a risk factor for maxillary hypoplasia and soft palate elongation: A functional – morphological study
Authors: Yoon A. J. , Zaghi S. , Ha S. , Law C. S. , Guilleminault C. , Liu S. Y. 
Published: October 2017

Structured AbstractObjectivesTo characterize associations between restricted tongue mobility and maxillofacial development.Setting and Sample PopulationCross‐sectional cohort study of 302 consecutive subjects from an orthodontic practice.Material and MethodsTongue mobility (measured with tongue range of motion ratio [TRMR] and Kotlow free tongue measurement) was correlated with measurements of the maxillofacial skeleton obtained from dental casts and cephalometric radiographs.ResultsTongue range of motion ratio and Kotlow measures of restricted tongue mobility were associated with (i) ratio of maxillary intercanine width to canine arch length, (ii) ratio of maxillary intermolar width to canine arch length and (iii) soft palate length. Restricted tongue mobility was not associated with hyoid bone position or Angle's skeletal classification.ConclusionsRestricted tongue mobility was associated with narrowing of the maxillary arch and elongation of the soft palate in this study. These findings suggest that variations in tongue mobility may affect maxillofacial development.
The Line, the Void and the Current: Iron Age Art from a Design Theory Perspective
Authors: Romankiewicz Tanja 
Published: October 2017

SummaryObjects from the European Iron Age decorated with swirls and scrolls, faces and figures, and generally referred to as Early Celtic Art, can offer deep insight into later prehistoric notions of creativity. By drawing on archaeology and social anthropology, art and architectural design, this theoretical discourse investigates the design processes involved in the creation of Early Celtic Art. Rather than attempting to decipher a meaning behind decoration, this enquiry uses architectural ‘Design Theory’ to explore the implications of certain design choices. It starts with the premise that these designs are integral to the objects in order to identify different layers of complexity, innovation and emulation, and ends with wider reflections on who was creative and how. This approach, borrowed from architectural analysis, aims to open a new line of enquiry into the fascinating world of Iron Age creativity.
Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review
Authors: Letsas Konstantinos P. , Asvestas Dimitrios , Baranchuk Adrian , Liu Tong , Georgopoulos Stamatis , Efremidis Michael , Korantzopoulos Panagiotis , Bazoukis George , Tse Gary , Sideris Antonios , Takagi Masahiko , Ehrlich Joachim R. 
Published: October 2017

AbstractBrugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter‐defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow‐up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases.
Quantitative trait loci underlying soybean seed tocopherol content with main additive, epistatic and QTL × environment effects
Authors: Liu Huancheng , Cao Guanglu , Wu Depeng , Jiang Zhenfeng , Han Yingpeng , Li Wenbin 
Published: October 2017

AbstractSoybean (Glycine max [L.] Merrill) seeds are a major source of tocopherols (Toc), which could significantly improve immune system health of human and prevent or treat many serious diseases. Selection for higher Toc contents of seeds could increase nutritional value of soybean‐derived food, laying on an important breeding goal for many soybean breeders. The present objectives of the work were to evaluate various genetic effects of QTL associated with individual and total Toc content based on a RIL population (“Beifeng 9” × “Freeborn”) in six environments to improve the efficiency of molecular marker‐assisted selection (MAS) for high‐Toc breeding. The results described that eighteen, thirteen, eleven and thirteen QTL were associated with α‐Toc, γ‐Toc, δ‐Toc and total Toc content, respectively, and have additive main effects (a) and/or additive × environment interaction effects (ae) in certain environments. Among them, four QTL for α‐Toc, two QTL for γ‐Toc, one QTL for δ‐Toc and four QTL for total Toc could increase α‐Toc, γ‐Toc, δ‐Toc and total Toc content via significant a effect, respectively, which have stronger stability in different years and locations. It implied a value for MAS. Additionally, twenty‐five, fifteen, eleven and twenty epistatic pairwise QTL associated with α‐Toc, γ‐Toc, δ‐Toc and total Toc contents, respectively, were detected. The genetic information of the QTL effects obtained here would be beneficial for breeding soybean variety with high‐Toc content by MAS.
Considering self‐interests and symbolism together: How instrumental and value‐expressive motives interact to influence supervisors’ justice behavior
Authors: Qin Xin , Ren Run , Zhang Zhi‐Xue , Johnson Russell E. 
Published: October 2017

AbstractDrawing upon functional theories of attitudes and the organizational justice literature, the current research suggests that people's attitudes toward justice likely serve an instrumental function (grounded in self‐interest, rewards maximization, and punishment minimization) as well as a value‐expressive function (grounded in the expression of self‐concept and values). Importantly, these two functions co‐exist and interact to influence supervisors’ justice behavior and the consistency of such behavior via supervisors’ justification for unjust behavior. Findings from a set of experimental and correlational studies confirmed these predictions. The positive effects of supervisors’ value‐expressive function on justice behavior and its consistency were stronger when their instrumental function was lower (vs. higher), and justification for unjust behavior mediated these effects. Also, supplementary analyses showed that the consistency of supervisors’ justice behavior positively predicted subordinates’ overall justice perceptions beyond the effects of the overall level of justice behavior. We conclude by discussing the theoretical and practical implications of these findings.
Citizenship allocation and withdrawal: Some normative issues
Authors: Ferracioli Luara 
Published: October 2017

AbstractPhilosophical discussion about citizenship has traditionally focused on the questions of what citizenship is, its relationship to civic virtue and political participation, and whether or not it can be meaningfully exercised at the supra‐national level. In recent years, however, philosophers have turned their attention to the legal status attached to citizenship and have questioned existing principles of citizenship allocation and withdrawal. With regard to the question of who is morally entitled to citizenship, philosophers have argued for principles of citizenship allocation that go beyond birth and lineage and have focused instead on the value of political attachment and located life plans. These principles have several advantages over existing legal principles, but they suffer from being under‐specified, as well as being over and under‐inclusive. With regard to loss of citizenship, philosophers have primarily denounced citizenship withdrawal as a form of punishment by appealing to principles of fair and equal treatment. However, theories purporting to show that denationalization is always wrong have trouble explaining why loss of citizenship is so problematic for persons who have committed the most horrendous crimes against their fellow citizens and who, in so doing, have in effect self‐excluded from the political community.
Pollination in the Chilean Mediterranean‐type ecosystem: a review of current advances and pending tasks
Authors: Medel R. , González‐Browne C. , Fontúrbel F.E. 
Published: October 2017

AbstractWe conducted a systematic review of the scientific literature published on plant–pollinator interactions, from both the plant and pollinator perspective, in the Chilean Mediterranean‐type ecosystem (MTE hereafter). Our search identified 69 published papers on 235 native plant species from 62 families. Less than 7.9% of the flowering species inhabiting the Chilean Mediterranean have been studied, and most studies were restricted to only one locality and one reproductive season. The geographic location of the studies differed from a random pattern, showing two well‐defined areas where most studies were conducted. Likewise, most studies in the Andes Range were performed above 2000 m a.s.l. The number of species of flower visitor per plant species was low (4.25 ± 0.22), which probably results from the historical and biogeographic isolation of Chile. This literature survey shows that studies relating floral traits with pollinator attraction and plant reproduction are the most frequent topics of research, reaching 37.6% of studies, followed by studies that examine pollination in relation to human impact (16.1%), micro‐ and macroevolution (14.0%), relationships between pollination and other ecological interactions (10.8%), community and network assessments (11.8%), and effects of abiotic variables on pollination interactions (9.7%). Our review highlights a lack of research on the effects of pollination for anthropogenic land use especially as agricultural practice is one of the most salient features of the Chilean MTE. Future directions to increase our understanding of the role of plant–pollinator relationships for biodiversity maintenance should include: to extend the taxonomic and geographic scope of research, to increase the number of spatial and temporal replicates, to increase the number of studies on pollination networks as they provide estimates of community complexity and putative stability, to develop studies that estimate the importance of pollination for plant demographic parameters and conservation, and to conduct studies that estimate the ecological service provided by Chilean native pollinators for crop yield and sustainable agriculture.
Strength training improves double‐poling performance after prolonged submaximal exercise in cross‐country skiers
Authors: Øfsteng S. , Sandbakk Ø. , van Beekvelt M. , Hammarström D. , Kristoffersen R. , Hansen J. , Paulsen G. , Rønnestad B. R. 
Published: October 2017

The purpose of this study was to investigate the effects of adding strength training with or without vibration to cross‐country (XC) skiers’ endurance training on double‐poling (DP) performance, physiological, and kinematic adaptations. Twenty‐one well‐trained male XC‐skiers combined endurance‐ and upper‐body strength training three times per week, either with (n = 11) or without (n = 10) superimposed vibrations for 8 weeks, whereas eight skiers performed endurance training only (CON). Testing included 1RM in upper‐body exercises, work economy, neural activation, oxygen saturation in muscle, and DP kinematics during a prolonged submaximal DP roller ski test which was directly followed by a time to exhaustion (TTE) test. TTE was also performed in rested state, and the difference between the two TTE tests (TTEdiff) determined the ability to maintain DP performance after prolonged exercise. Vibration induced no additional effect on strength or endurance gains. Therefore, the two strength training groups were pooled (STR, n = 21). 1RM in STR increased more than in CON (P < .05), and there were no differences in changes between STR and CON in any measurements during prolonged submaximal DP. STR improved TTE following prolonged DP (20 ± 16%, P < .001) and revealed a moderate effect size compared to CON (ES = 0.80; P = .07). Furthermore, STR improved TTEdiff more than CON (P = .049). In conclusion, STR superiorly improved 1RM strength, DP performance following prolonged submaximal DP and TTEdiff, indicating a specific effect of improved strength on the ability to maintain performance after long‐lasting exercise.
Approaches to civil society in authoritarian states: The case of China
Authors: Gleiss Marielle Stigum , Sæther Elin 
Published: October 2017

AbstractBoth civil society in China and research on Chinese civil society have developed profoundly over the last three decades. Research on Chinese civil society can be classified into two categories: a structure‐oriented approach and an agency‐oriented approach. Both approaches acknowledge the state's dominant position in restricting the political space for civil society engagement, but they differ in their understanding of state–civil society relations. A key concern within the structure‐oriented approach is to analyze how the autonomy of civil society organizations is shaped by their structural position vis‐à‐vis the state. Agency‐oriented scholars, on the other hand, reject the analytical focus on structural autonomy. Instead, they build on a more nuanced understanding of the authoritarian yet nonmonolithic context in China and analyze how civil society organizations develop specific strategies to be able to operate within their restricted political space. In particular, agency‐oriented scholars have analyzed two ways in which organizations exercise agency: by strategically developing formal or informal ties with state actors and by bringing their engagement into the public sphere to raise awareness and express their voice. What could be further developed in the agency‐oriented approach is, however, a deeper understanding of the political dimensions of civil society agency.
Morphology‐based modeling of aggregation effect on the patch area size for GlobeLand30 data
Authors: Tan Shiteng , Xu Zhu , Ti Peng , Li Zhilin 
Published: October 2017

AbstractCurrently, research on the scale effect mainly concentrates on revealing and describing the phenomenon; little work has been done to model the scaling of analysis indicators along with the scale change of the data. Such models can help explain and estimate the scale effect and are thus of great interest. As patch morphology significantly influences patch evolution over data scale transformation, this study proposes a model that applies patch morphology metrics to explain and estimate the change in the patch and category area ratio in the upscaling of raster categorical data. In the experimental evaluation, area scaling of GlobeLand30 data under majority aggregation is studied intensively. Two metrics—the ratio of the patch area after aggregation to its original area and the ratio of the category area after aggregation to its original area—are used in this evaluation. The experimental results indicate that this model can adequately describe the pattern of the patch area change and precisely estimate the category area change arising from the resolution change. It is also demonstrated that the spatial distribution of patches has much less influence on the change in the category areas compared with the patch morphology. Additionally, the modeling approach in this study may also be adopted to investigate the scaling of other landscape metrics.