bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive health needs of female sex workers and opportunities for enhanced prevention of mother-to-child transmission efforts in sub-Saharan Africa
Authors: Schwartz Sheree R , Papworth Erin , Ky-Zerbo Odette , Sithole Bhekie , Anato Simplice , Grosso Ashley , Ouedraogo Henri Gautier , Tchalla Jules , Ntshangase Cebisile , Ketende Sosthenes , Baral Stefan 
Published: November 2015

IntroductionHIV infection and pregnancy are both common among female sex workers (FSW), indicating the need for prevention of mother-to-child transmission (PMTCT) among FSW.MethodsFSW were enrolled into studies in Swaziland, Burkina Faso and Togo using respondent-driven sampling. Women completed interview-administered socio-behavioural surveys and HIV counselling and testing. This secondary analysis describes contraceptive use and attempted pregnancy among reproductive-aged FSW (16–49 years). Robust Poisson regression with generalised estimating equations to account for clustering within recruitment networks was used to separately estimate associations between current unmet contraceptive need and attempted pregnancy among FSW.ResultsOverall 1666 FSW were enrolled, 1372 (82.4%) of whom had ever been pregnant. In Togo and Burkina Faso, 83 FSW reported a prior HIV diagnosis and having a child, of which 12.1% (10/83) reported a child known to be HIV-positive. Twenty-five per cent of FSW had an unmet need for contraception; 9% of FSW employed dual contraception, including highly effective non-barrier methods and consistent condom use. Consistent condom use varied substantially by partner type and was higher with clients than non-paying partners. Nineteen per cent (n=313/1666) of FSW were trying to conceive. HIV-positive, undiagnosed FSW were more likely to be trying to conceive as compared to HIV-negative FSW; among 98 HIV-positive women trying to conceive, 25.5% were on antiretroviral therapy.ConclusionsFSW have varying reproductive goals and contraceptive usage. Efforts to improve coverage of comprehensive family planning – including efforts to increase HIV testing and engagement in treatment among FSW trying to conceive – are necessary for PMTCT.
CPLEAR data on semileptonic decay of K0, K̄0 and the mass difference of KL0 and KS0 mesons
Authors: Dubnicka Stanislav , Dubnickova Anna-Zuzana 
Published: November 2015

It is demonstrated that for a determination of the mass difference of the [Formula: see text] and [Formula: see text] mesons an explicit theoretical formula to be derived by an assumption of the CP-conservation has been used by CPLEAR Collaboration in a fitting of the time-dependent CPLEAR data on ASYMMETRY. So, in such procedure the mass difference [Formula: see text] of the [Formula: see text] and [Formula: see text] mesons has been found and in no case [Formula: see text] one as in this case the CP-violation has to be considered.
Study of di-electron production in quasi-free n-p interactions at HADES set-up
Authors: Jerusalimov A. P. , Lykasov G. I. 
Published: November 2015

The study of [Formula: see text]-pairs production in n-p interactions was carried out at HADES set-up due to irradiation of proton target by deuteron beam at [Formula: see text] AGeV. The momentum and angular distributions of proton-spectator an effective masses of [Formula: see text]-pairs were satisfactory described by a sum of various reactions of quasi-free n-p and p-p interactions.
Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
Authors: Choi Dongwon , Ramu Swapnika , Park Eunkyung , Jung Eunson , Yang Sara , Jung Wonhyeuk , Choi Inho , Lee Sunju , Kim Kyu Eui , Seong Young Jin , Hong Mingu , Daghlian George , Kim Daniel , Shin Eugene , Seo Jung In , Khatchadourian Vicken , Zou Mengchen , Li Wei , De Filippo Roger , Kokorowski Paul , Chang Andy , Kim Steve , Bertoni Ana , Furlanetto Tania Weber , Shin Sung , Li Meng , Chen Yibu , Wong Alex , Koh Chester , Geliebter Jan , Hong Young-Kwon 
Published: November 2015

Abstract
Papillary thyroid cancer (PTC) is one of the most common endocrine malignancies associated with significant morbidity and mortality. Although multiple studies have contributed to a better understanding of the genetic alterations underlying this frequently arising disease, the downstream molecular effectors that impact PTC pathogenesis remain to be further defined. Here, we report that the regulator of cell fate specification, PROX1, becomes inactivated in PTC through mRNA downregulation and cytoplasmic mislocalization. Expression studies in clinical specimens revealed that aberrantly activated NOTCH signaling promoted PROX1 downregulation and that cytoplasmic mislocalization significantly altered PROX1 protein stability. Importantly, restoration of PROX1 activity in thyroid carcinoma cells revealed that PROX1 not only enhanced Wnt/β-catenin signaling but also regulated several genes known to be associated with PTC, including thyroid cancer protein (TC)-1, SERPINA1, and FABP4. Furthermore, PROX1 reexpression suppressed the malignant phenotypes of thyroid carcinoma cells, such as proliferation, motility, adhesion, invasion, anchorage-independent growth, and polyploidy. Moreover, animal xenograft studies demonstrated that restoration of PROX1 severely impeded tumor formation and suppressed the invasiveness and the nuclear/cytoplasmic ratio of PTC cells. Taken together, our findings demonstrate that NOTCH-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma and suggest that PROX1 reactivation may represent a potential therapeutic strategy to attenuate disease progression Cancer Res; 76(3); 582–93. ©2015 AACR.
The Trojan Horse Tale Revisited: An Eye on Metastatic Spread of Carcinoma Cells
Authors: Grajewski Rafael S. , Bosch Jacobus J. , Bruns Heiko , Cursiefen Claus , Heindl Ludwig M. 
Published: November 2015

Abstract
The metastatic spread of carcinoma cells is not fully understood. Here, we compare the peripheral blood mononuclear cells (PBMC) and intraocular metastatic cells in parotid gland carcinoma with the PBMCs of healthy donors by immunohistochemistry and flow cytometry. We found Ber-EP4 tumor marker–positive carcinoma cells in the aqueous humor of the patient's right eye and a CD45 and Ber-EP4–expressing PBMC population in his blood. These Ber-EP4–expressing cells exhibited a monocytic-myeloid phenotype with coexpression of CD11b, CD115, and the macrophage marker CD172a (SIRP-α). Uptake of pHrodogreen revealed their phagocytic activity. Our findings suggest that the tumor cells in the anterior chamber originally derived from cell fusions between tumor cells and myeloid cells in the peripheral blood. Thus, metastases of a solid malignancy could use monocytes–macrophages as the Trojan horse to enter the eye. Cancer Immunol Res; 4(2); 92–94. ©2015 AACR.
A first record of Abryna regispetri Paiva, 1860 (Cerambycidae: Lamiinae: Pteropliini) and its redescription from india
Authors: Ghate H. V. , Agarwala B. K. 
Published: November 2015

<p><strong> </strong>A cerambycid beetle, <em>Abryna regispetri</em> Paiva, 1860, is reported as a first record from India and is redescribed after its original description from Cambodia in 1860. The present record of the species adds to its distribution range in southeast Asia.</p><div> </div>
Himalayan Vultures in Khodpe, far-west Nepal: is there any threat?
Authors: Joshi Manoj Kumar , Chalise Mukesh Kumar , Chaudhary Anand , Katuwal Hem Bahadur 
Published: November 2015

<p>There is evidence that Himalayan Vulture <em>Gyps himalayensis</em> is susceptible to the veterinary drug diclofenac, which is responsible for the decline of other <em>Gyps </em>species across South Asia. Unlike other <em>Gyps </em>species, there is little quantitative data to assess Himalayan Vultures population. Based on observation, we analyzed the flock size and breeding success of the Himalayan Vultures on two cliffs of Khodpe in Baitadi District, far-west Nepal. The mean flock size of Himalayan Vulture was 25.83±6.33. Overall breeding success was 90.9% based on active nests. We also conducted a questionnaire survey to assess the perceived threats in the view of local people to vultures and these threats include loss of food, veterinary drug, lack of proper nest sites, and lack of public awareness. Additionally, 76% of the respondents felt that vultures were decreasing in the area, 94.7% were not aware of the toxicity of diclofenac to vultures, and very few (2%) knew about the availability of meloxicam as a safe alternative drug. The colony we studied is one of the few remaining known breeding populations, which provide baseline information from far-west Nepal, thus we recommend for conservation and continuous monitoring of this species to understand their population change and breeding biology.</p><div> </div>
Occurrence of three Western Ghats elements in dry evergreen forest of Gingee Hills, Eastern Ghats of Tamil Nadu, India
Authors: Balachandran N. , Rajendiran K. , Gastmans W. F. 
Published: November 2015

<p>The botanical exploration of Gingee hills, Tamil Nadu, India resulted in collection of three species <em>viz</em>., <em>Diospyros affinis </em>Thwaites, <em>Drypetes porteri</em> (Gamble) Pax &amp; K. Hoffm. and <em>Premna wightiana </em>Schauer have showing their extended geographical distribution in Eastern Ghats. This study revealed about the disjunct distribution, ecology and the present status of these three species from the Eastern Ghats.</p><div> </div>
Is Admission to the Intensive Care Unit Associated With Chronic Opioid Use? A 4-Year Follow-Up of Intensive Care Unit Survivors
Authors: Yaffe Paul B. , Green Robert S. , Butler Michael B. , Witter Tobias 
Published: November 2015

Purpose: To describe opioid use before and after intensive care unit (ICU) admission and to identify factors associated with chronic opioid use upto 4 years after ICU discharge. Methods: Retrospective review of adult patients admitted to the ICU at a tertiary care center between January 1, 2005, to December 31, 2008. We defined “nonuser,” “intermittent,” and “chronic” opioid status by abstinence, use in <70%, and >70% of days for a given time period, respectively. We assessed opioid use at 3 months prior to ICU admission, at discharge, and annually for upto 4 years following ICU discharge. Results: A total of 2595 ICU patients were included for surgical (48.6%), medical (38.4%), and undetermined (13%) indications. The study population included both elective (26.9%) and emergent (73.1%) admissions. Three months prior to ICU admission, 76.9% were nonusers, 16.9% used opioids intermittently, and 6.2% used opioids chronically. We found an increase in nonuser patients from 87.8% in the early post-ICU period to 95.6% at 48-month follow-up. Consequently, intermittent and chronic opioid use dropped to 8.6% and 3.6% at discharge and 2.6% and 1.8% at 48-month follow-up, respectively. Prolonged hospital length of stay was associated with chronic opioid use. Conclusion: Admission to ICU and duration of ICU stay were not associated with chronic opioid use.
Development and in vitro evaluation of infection resistant materials: A novel surface modification process for silicone and Dacron
Authors: Hussain Ali , Curry Benjamin , Cahalan Linda , Minkin Steven , Gartner Mark , Cahalan Patrick 
Published: November 2015

Silicone and Dacron are used in a wide spectrum of implantable and indwelling medical products. They elicit a foreign body response, which results in a chronic inflammatory environment and collagenous encapsulation of the medical device that compromises the immune system’s ability to effectively fight infections at the biomaterial surface. The objective of this work is to evaluate a novel process to modify silicone and Dacron with a bioactive collagen surface coupled to a gentamicin impregnated hydrogel graft and assess the surface’s cytocompatibility and infection resistance properties. Samples of silicone and polyethylene terephthalate (Dacron velour) were modified by plasma deposition and activation followed by a co-polymer acrylic acid (AA)/acrylamide (AAm) hydrogel graft and covalent immobilization of a bioactive collagen surface. The modified surfaces were characterized using FTIR, contact angle, staining, SEM, and XPS. The poly (AA-AAm) hydrogel was impregnated with gentamicin and tested for controlled release characteristics. Each modified surface was evaluated for its ability to resist infection and to promote normal healing as measured by bacterial growth inhibition ( Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa) in both broth and agar conditions as well as using fluorescence microscopy to observe adherence of 3T3-NIH fibroblasts. The addition of the poly (AA-AAm) hydrogel with gentamicin inhibited bacterial growth and the subsequent addition of the collagen surface promoted robust fibroblast adhesion on both silicone and Dacron materials. Thorough surface characterization and in vitro bacterial and fibroblast evaluation results suggest that this novel surface bioengineering process generated a highly effective surface on silicone and Dacron with the potential to reduce infection and promote healing.
Personality Disorder and Perceived Parenting in Chinese Students of Divorced and Intact Families
Authors: Xu You , Lin Lianghua , Yang Lan , Zhou Lina , Tao Yi , Chen Wanzhen , Chai Hao , Wang Wei 
Published: November 2015

Background: Nurturing environment contributes to the personality development of young people, but how inappropriate parental bonding from biological parents influences the personality disorder functioning styles of their offspring in divorced families remains unclear. Objective: We aimed to find out the relationship between parenting styles and students’ disordered personality in divorced families. Methods: The Parental Bonding Instrument (PBI) and the Parker Personality Measure (PERM) were administered to 60 Chinese students from divorced family (Divorced group) and 120 controls (matched in age and gender) from intact family (Intact group). The depressive tendency of the participants was measured with the Plutchik–van Praag Depression Inventory (PVP). Results: PERM borderline style was more prominent when father was perceived as secondary carer than primary carer in Divorced group. When father was perceived as secondary carer, PERM borderline style was more obvious in Divorced group than in Intact group. Maternal autonomy denial and care predicted PERM narcissistic and dependent styles in Divorced group, when mother was perceived as primary carer. In the Intact group, when mother was perceived as secondary carer, maternal care was lower than when mother was perceived as primary carer. Some parental PBI scales predicted certain PERM scales regardless of the carer order. Conclusions: The results imply that in divorced family, biological father should be more involved in young people’s daily life, and biological mother should show more care and less autonomy denial. In intact family, more care, less freedom control, and less autonomy denial from both parents are important in the personality development of their offspring.
Reduction of Venous Thromboembolism in Surgical Patients Using a Mandatory Risk-Scoring System: 5-Year Follow-Up of an American College of Surgeons National Surgical Quality Improvement Program
Authors: Nimeri Abdelrahman A. , Gamaleldin Maysoon M. , McKenna Karen L. , Turrin Nicolas P. , Mustafa Bisher O. 
Published: November 2015

Background: Sheikh Khalifa Medical City’s (SKMC) surgery institute was identified as a high outlier in the incidence of venous thromboembolism (VTE; deep vein thrombosis [DVT] and pulmonary embolism [PE]) based on the semiannual report of the American College of Surgeon’s National Surgical Quality Improvement Program (ACS NSQIP) in June 2010. Aim: To report our rates of VTE at SKMC, the results, and 5-year follow-up after an ACS NSQIP quality improvement program. Methods: A multidisciplinary VTE task force was established in June 2010. We instituted a compulsory risk assessment for VTE and utilized the ACS NSQIP best practice guidelines to review cases of VTE. We prospectively evaluated the observed/expected (O/E) ratio for DVT/PE after implementing the action plan. Results: The O/E ratio for PE/DVT in general and general/vascular (GV) surgery was 6.00 and 4.86 in June 2010. Our compliance with ordering antithrombotic prophylactic measures was as low and it improved to 100% and our O/E ratio decreased to 1.18 and 1.5 in July 2011 and stabilized for the next 4 years. Currently, our compliance with ordering antithrombotic prophylactic measures is 100%, and our last 2 O/E ratio for DVT/PE are 0.74 and 0.75 in GV surgery and 0.82 and 0.78 in the entire surgery institute, respectively, and we are considered an exemplary site of the ACS NSQIP in GV surgery. Conclusion: A compulsory risk assessment for VTE has led to an overall improvement in DVT/PE rates in the surgery institute and for GV surgery to become an exemplary site for the ACS NSQIP.
The Relationship Between Serum Endocan Levels With the Presence of Slow Coronary Flow: A Cross-Sectional Study
Authors: Kundi Harun , Gok Murat , Kiziltunc Emrullah , Topcuoglu Canan , Cetin Mustafa , Cicekcioglu Hulya , Ugurlu Burcu , Ulusoy Feridun Vasfi 
Published: November 2015

Background: The aim of this study was to investigate the relationship between endocan levels with the presence of slow coronary flow (SCF). Methods: In this cross-sectional study, a total of 88 patients, who admitted to our hospital, were included in this study. Of these, 53 patients with SCF and 35 patients with normal coronary flow were included in the final analysis. Coronary flow rates of all patients were determined by the Timi Frame Count (TFC) method. Results: In correlation analysis, endocan levels revealed a significantly positive correlation with high sensitive C-reactive protein and corrected TFC. In multivariate logistic regression analysis, the endocan levels were found as independently associated with the presence of SCF. Finally, using a cutoff level of 2.3, endocan level predicted the presence of SCF with a sensitivity of 77.2% and specificity of 75.2%. Conclusion: In conclusion, our study showed that higher endocan levels were significantly and independently related to the presence of SCF.
Factors associated with pharmacists’ perceptions of their working conditions and safety and effectiveness of patient care
Authors: Tsao Nicole W. , Lynd Larry D. , Gastonguay Louise , Li Kathy , Nakagawa Bob , Marra Carlo A. 
Published: November 2015

Background: In recent years, the role of pharmacists has changed, as have various provincial legislations, which now allow pharmacists to provide additional health services to patients. With these changes comes growing concern about how well the current pharmacy working environment is adapting and whether it may also be creating work-related stress that may contribute to potentially unsafe practices of patient care. Methods: To characterize the current working conditions of pharmacists in British Columbia, an online survey was developed and distributed to all College of Pharmacists of BC (CPBC) registrants by email. The survey consisted of questions on pharmacists’ demographics, practice setting and perceptions of workplace conditions. Responses were collected from October 1 to November 10, 2013. All data were summarized using descriptive statistics, and regression models were constructed to assess the association between various factors and pharmacists’ self-reported working conditions. Results: Twenty-three percent (1241/5300) of pharmacists registered with the CPBC responded, with 78% working in the community pharmacy setting (58% chain, 19% independent). Pharmacists mostly disagreed with the statements that they had enough time for breaks or lunches or to do their jobs, as well as enough staffing support. Pharmacists’ perceptions of their workplace environment were negatively associated with workplace-imposed advanced service quotas (for medication reviews, immunizations and prescription adaptations); being employed at chain store pharmacies, compared to independent pharmacies or hospitals/long-term care settings; and higher prescription volume. Discussion: Pharmacists working in chain community pharmacies who are required to meet monthly quotas for expanded services reported a substantial negative impact on their working conditions and perceived safety of patient care. Can Pharm J (Ott) 2016;149:xx-xx.
Surface modification of pure titanium to improve its anti-inflammatory function
Authors: Sun Hanwen , Zhang Yancong , Dou Linbo , Song Xinfeng , Sun Chunyan 
Published: November 2015

Objective: Surface-modified titanium material was prepared to explore its corrosion resistance and microbial adhesion. Methods: Atmospheric pressure plasma was used to modify the surface of pure titanium. The surface morphology and adhesion morphology of P. gingivalis (Porphyromonas gingivalis) were observed through morphology scanning electron microscopy. Reactive oxygen species (ROS) formation was detected using a fluorescence spectrophotometer. Electrochemical corrosion properties of the material were detected using simulated fluids and SAGF artificial saliva as electrolyte. Bacteria suspension absorbance was tested using an enzyme standard. Results: After plasma modification, the material surface exhibited numerous ROS formations and improved wettability. Compared with the control group, corrosion potential was higher but corrosion current was lower in simulated body fluids and artificial saliva. Bacterial-suspension absorbance was significantly lower than that in the control group on days 3 and 5 ( P <0.05). Conclusion: The electrochemical and microbial corrosion performance of titanium can be improved by atmospheric pressure plasma. Therefore, this method can thus be used for the surface modification of oral and bone implant materials.