bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Alkynylation of 2‐Trifluoroacetyl Imidazoles Catalyzed by Bis‐Cyclometalated Rhodium(III) Complexes Containing Pinene‐Derived Ligands
Authors: Zheng Yu , Harms Klaus , Zhang Lilu , Meggers Eric 
Published: June 2016

AbstractChiral rhodium(III) complexes containing two cyclometalating 2‐phenyl‐5,6‐(S,S)‐pinenopyridine ligands and two additional acetonitriles are introduced as excellent catalysts for the highly enantioselective alkynylation of 2‐trifluoroacetyl imidazoles. Whereas the ligand‐based chirality permits the straightforward synthesis of the complexes in a diastereomerically and enantiomerically pure fashion, the metal‐centered chirality is responsible for the asymmetric induction over the course of the catalysis. For comparison, the analogous iridium congeners provide only low enantioselectivity, and previously reported benzoxazole‐ and benzothiazole‐based catalysts do not show any catalytic activity for this reaction under standard reaction conditions.
Adsorption mechanism of the simulated red mud from diaspore with high levels of silicon and iron
Authors: Liu Jinwei , Hu Huiping , Wang Meng , Chen Qiyuan , Dai Kuan 
Published: June 2016

AbstractThe flocculation effect of Hx‐600 on the simulated red mud of the Bayer process from diaspore with high levels of silicon and iron was investigated, and a flocculant with high content of hydroxamate groups (HCPAM) and sodium polyacrylate (PAAS) was chosen as the model compound of Hx‐600. The typical silicon‐containing and iron‐containing monominerals in red mud, hydration grossular and hematite, were correspondingly synthesized, and the adsorption mechanism with HCPAM or PAAS was investigated using FTIR and XPS, respectively. The results reveal physical adsorption of HCPAM or PAAS on the surfaces of hydration grossular and chemisorption of HCPAM or PAAS on the surfaces of hematite. The atomic Mulliken populations of the model compounds of HCPAM and PAAS were calculated by quantum chemical calculation. The results show that a five‐membered ring may be formed on the surfaces of HCPAM‐treated hematite and a four‐membered ring may be formed on the surfaces of PAAS‐treated hematite. A stronger adsorption of the flocculant with hydroxamate groups on the hematite surfaces can be estimated, compared to carboxyl groups. Therefore, the improvement of settling performance achieved by Hx‐600 could be attributed to the high content of hydroxamate groups and high molecular weight (mass) of Hx‐600. A chemisorption with a bridging flocculation between the iron‐containing component in red mud and Hx‐600, and a physical adsorption with a bridging flocculation between the silicon‐containing component in red mud and Hx‐600 can enhance the settling performance of the simulated red mud of the Bayer process from diaspore with high levels of silicon and iron.
Breast intraductal papillomas without atypia in radiologic‐pathologic concordant core‐needle biopsies: Rate of upgrade to carcinoma at excision
Authors: Pareja Fresia , Corben Adriana D. , Brennan Sandra B. , Murray Melissa P. , Bowser Zenica L. , Jakate Kiran , Sebastiano Christopher , Morrow Monica , Morris Elizabeth A. , Brogi Edi 
Published: June 2016

BACKGROUNDThe surgical management of mammary intraductal papilloma without atypia (IDP) identified at core‐needle biopsy (CNB) is controversial. This study assessed the rate of upgrade to carcinoma at surgical excision (EXC).METHODSThis study identified women with a CNB diagnosis of intraductal papilloma without atypia or carcinoma at a cancer center between 2003 and 2013. Radiologic‐pathologic concordance was assessed for all cases, and discordant cases were excluded. The radiologic and clinicopathologic features of patients with a CNB diagnosis of IDP were correlated with an upgrade to carcinoma at EXC.RESULTSThe study population consists of 189 women with 196 IDPs; 166 women (171 IDPs) underwent EXC. The upgrade rate was 2.3% (4 of 171). The upgraded lesions were 2 invasive lobular carcinomas and 2 cases of ductal carcinoma in situ (DCIS). One case of DCIS involved the residual IDP, whereas the other 3 carcinomas were ≥ 8 mm away. Twenty‐four women (25 IDPs) did not undergo EXC and had stable imaging on follow‐up (median, 23.5 months).CONCLUSIONSThe upgrade rate at EXC for IDPs diagnosed at CNB with radiologic‐pathologic concordance was 2.3%. These findings suggest that observation is appropriate for patients with radiologic‐pathologic concordant CNB yielding IDP, regardless of its size. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2819–2827. © 2016 American Cancer Society
Does FLT3 mutation impact survival after hematopoietic stem cell transplantation for acute myeloid leukemia? A Center for International Blood and Marrow Transplant Research (CIBMTR) analysis
Authors: Deol Abhinav , Sengsayadeth Salyka , Ahn Kwang Woo , Wang Hai‐Lin , Aljurf Mahmoud , Antin Joseph Harry , Battiwalla Minoo , Bornhauser Martin , Cahn Jean‐Yves , Camitta Bruce , Chen Yi‐Bin , Cutler Corey S. , Gale Robert Peter , Ganguly Siddhartha , Hamadani Mehdi , Inamoto Yoshihiro , Jagasia Madan , Kamble Rammurti , Koreth John , Lazarus Hillard M. , Liesveld Jane , Litzow Mark R. , Marks David I. , Nishihori Taiga , Olsson Richard F. , Reshef Ran , Rowe Jacob M. , Saad Ayman A. , Sabloff Mitchell , Schouten Harry C. , Shea Thomas C. , Soiffer Robert J. , Uy Geoffrey L. , Waller Edmond K. , Wiernik Peter H. , Wirk Baldeep , Woolfrey Ann E. , Bunjes Donald , Devine Steven , de Lima Marcos , Sandmaier Brenda M. , Weisdorf Dan , Khoury Hanna Jean , Saber Wael 
Published: June 2016

BACKGROUNDPatients with FMS like tyrosine kinase 3 (FLT3)‐mutated acute myeloid leukemia (AML) have a poor prognosis and are referred for early allogeneic hematopoietic stem cell transplantation (HCT).METHODSData from the Center for International Blood and Marrow Transplant Research (CIBMTR) were used to evaluate 511 adult patients with de novo AML who underwent HCT during 2008 through 2011 to determine whether FLT3 mutations had an impact on HCT outcomes.RESULTSIn total, 158 patients (31%) had FLT3 mutations. Univariate and multivariate analyses revealed an increased risk of relapse at 3 years in the FLT3 mutated group compared with the wild‐type (WT) group (38% [95% confidence interval (CI), 30%‐45%] vs 28% [95% CI, 24%‐33%]; P = .04; relative risk, 1.60 [95% CI, 1.15‐2.22]; P = .0048). However, FLT3 mutation status was not significantly associated with nonrelapse mortality, leukemia‐free survival, or overall survival. Although more patients in the FLT3 mutated group died from relapsed primary disease compared with those in the WT group (60% vs 46%), the 3‐year overall survival rate was comparable for the 2 groups (mutated group: 49%; 95% CI, 40%‐57%; WT group: 55%, 95% CI, 50%‐60%; P = .20).CONCLUSIONSThe current data indicate that FLT3 mutation status did not adversely impact overall survival after HCT, and about 50% of patients with this mutation who underwent HCT were long‐term survivors. Cancer 2016;122:3005‐3014. © 2016 American Cancer Society.
A randomized phase 2 study exploring the role of bevacizumab and a chemotherapy‐free approach in HER2‐positive metastatic breast cancer: The HAT study (BOOG 2008‐2003), a Dutch Breast Cancer Research Group trial
Authors: Drooger Jan C. , van Tinteren Harm , de Groot Steffen M. , ten Tije Albert J. , de Graaf Hiltje , Portielje Johanneke E. A. , Jager Agnes , Honkoop Aafke , Linn Sabine C. , Kroep Judith R. , Erdkamp Frans L. G. , Hamberg Paul , Imholz Alex L. T. , van Rossum‐Schornagel Quirine C. , Heijns Joan B. , van Leeuwen‐Stok A. Elise , Sleijfer Stefan 
Published: June 2016

BACKGROUNDTo explore the role of bevacizumab and a chemotherapy‐free approach, the authors evaluated the combination of bevacizumab, trastuzumab, and paclitaxel (HAT) and the regimen of trastuzumab and bevacizumab (HA) with the addition of paclitaxel after progression (HA‐HAT) as first‐line treatment for patients with human epidermal growth factor receptor 2 (HER2)‐positive metastatic breast cancer.METHODSIn a noncomparative phase 2 trial, patients were randomized between HAT and HA‐HAT. The primary endpoint was the progression‐free rate at 1 year (1‐year PFR). In the HA‐HAT group, progression‐free survival (PFS) was separately established for HA (PFS1) and HAT (PFS2).RESULTSEighty‐four patients received HAT (n = 39) or HA‐HAT (n = 45). The 1‐year PFR was 74.4% (95% confidence interval [CI], 61.8%‐89.4%) and 62.2% (95% CI, 49.6%‐89.4%) in the HAT and HA‐HAT arms, respectively. The median PFS was 19.8 months (95% CI, 14.9‐25.6 months) in the HAT arm and 19.6 months (95% CI, 12.0‐32.0 months) in the HA‐HAT arm. In the HA‐HAT arm, the median PFS1 was 10.4 months (95% CI, 6.2‐15.0 months), and the median PFS2 was 8.2 months (95% CI, 7.0‐12.6 months). The number and severity of adverse events were comparable between the arms.CONCLUSIONSBoth HAT and HA‐HAT have promising activity in patients with HER2‐positive metastatic breast cancer. In particular, starting with only targeted agents and delaying chemotherapy is worth further exploration. Cancer 2016;122:2961‐2970. © 2016 American Cancer Society.
Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression in breast cancer FNA cell blocks and paired histologic specimens: A large retrospective study
Authors: Vohra Poonam , Buelow Benjamin , Chen Yunn‐Yi , Serrano Maria , Vohra Manjiv Singh , Berry Anna , Ljung Britt‐Marie 
Published: June 2016

BACKGROUNDMolecular analysis represents an increasingly important component of the pathologic examination of tumor specimens. Notably, the characterization of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression in breast cancer specimens provides critical prognostic and predictive information. The objective of the current study was to compare the concordance of these markers as determined on fine‐needle aspiration (FNA) cell blocks compared with tissue blocks prepared from surgical specimens.METHODSA total of 134 cases of breast carcinoma were identified from 2002 through 2014 with both FNA cell blocks (fixed in 10% formalin) and corresponding available tissue blocks and ER, PR, and HER2 were characterized in both specimens. Negative and positive concordances were determined for ER and PR in cell blocks compared with tissue blocks, and for HER2 immunohistochemistry on cell blocks and tissue blocks versus the corresponding reference method, fluorescence in situ hybridization (FISH).RESULTSConcordance for ER expression evaluated on a cell block compared with the corresponding tissue block was 96.2%. Concordance for PR expression was 77.5%. Overall agreement of HER2 FISH testing between cell blocks and tissue blocks was 96.7%. For both cell blocks and tissue blocks, HER2 expression by immunohistochemistry demonstrated ≥98% positive and negative concordance with the FISH reference method.CONCLUSIONSER, PR, and HER2 determination on FNA‐acquired cell block (fixed exclusively in 10% formalin) showed excellent agreement for ER and HER2 and moderate agreement for PR with the corresponding tissue block. These findings support the equivalency of ER and HER2 evaluation performed on FNA cell blocks compared with surgical tissue blocks. Cancer Cytopathol 2016;124:828‐35. © 2016 American Cancer Society.
Preparation of Novel Li4SiO4 Sorbents with Superior Performance at Low CO2 Concentration
Authors: Yang Xinwei , Liu Wenqiang , Sun Jian , Hu Yingchao , Wang Wenyu , Chen Hongqiang , Zhang Yang , Li Xian , Xu Minghou 
Published: June 2016

AbstractThis work produced Li4SiO4 sorbents through an impregnated‐suspension method to overcome its typical poor performance at low CO2 concentrations. A SiO2 colloidal solution and two different organic lithium precursors were selected. A bulgy surface morphology (and thus, the significantly enlarged reacting surface area) was obtained for Li4SiO4, which contributed to the high absorption capacity. As a result, the capacity in cyclic tests at 15 vol % CO2 was approximately 8 times higher than conventional Li4SiO4 prepared through a solid‐state reaction. The phenomenon of a progressively increasing capacity (i.e., sustainable usage) was observed over the 40 cycles investigated, and this increasing trend continued to the last cycle. Correspondingly, over the course of the multicycle absorption/ desorption processes, the sorbents evolve from lacking porosity to having a high number of micron‐sized pores.
A Comparative Study on the Reactivity of Various Ketohexoses to Furanics in Methanol
Authors: van Putten Robert‐Jan , van der Waal Jan C. , Harmse Martin , van de Bovenkamp Henk H. , de Jong Ed , Heeres Hero J. 
Published: June 2016

AbstractThe acid‐catalysed dehydration of the four 2‐ketohexoses (fructose, sorbose, tagatose and psicose) to furanics was studied in methanol (65 g L−1 substrate concentration, 17 and 34 mm sulfuric acid, 100 °C) with Avantium high‐throughput technology. Significant differences in the reactivities of the hexoses and yields of 5‐hydroxymethylfurfural (HMF) and its methyl ether (MMF) were observed. Psicose and tagatose were the most reactive, and psicose also afforded the highest combined yield of MMF and HMF of approximately 55 % at 96 % sugar conversion. Hydroxyacetylfuran and its corresponding methyl ether were formed as byproducts, particularly for sorbose and tagatose, with a maximum combined yield of 8 % for sorbose. The formation of hydroxyacetylfuran was studied through 13C NMR spectroscopy with labelled sorbose, which provided new insights into the reaction mechanism.
Social cognition in anorexia nervosa: Specific difficulties in decoding emotional but not nonemotional mental states
Authors: Brockmeyer Timo , Pellegrino Judith , Münch Hannah , Herzog Wolfgang , Dziobek Isabell , Friederich Hans‐Christoph 
Published: June 2016

ABSTRACTObjectiveBuilding on recent models of anorexia nervosa (AN) that emphasize the importance of impaired social cognition in the development and maintenance of the disorder, the present study aimed at examining whether women with AN have more difficulties with inferring other people's emotional and nonemotional mental states than healthy women.MethodSocial cognition was assessed in 25 adult women with AN and 25 age‐matched healthy women. To overcome limitations of previous research on social cognition in AN, the processing of social information was examined in a more complex and ecologically valid manner. The Movie for the Assessment of Social Cognition (MASC) reflects complex real‐life social interaction and allows for disentangling emotional and non‐emotional mental state inference as well as different types of errors in mentalizing.ResultsWomen with AN showed poorer emotional mental state inference, whereas non‐emotional mental state inference was largely intact. Groups did not differ in undermentalizing (overly simplistic theory of mind) and overmentalizing (overly complex or over‐interpretative mental state reasoning). Performance in the MASC was independent of levels of eating disorder psychopathology and symptoms of depression and anxiety.DiscussionThe findings suggest that AN is associated with specific difficulties in emotional mental state inference despite largely intact nonemotional mental state inference. Upon replication in larger samples, these findings advocate a stronger emphasis on socio‐emotional processing in AN treatment. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:883–890)
Alkyl esters content and other quality parameters in oil mill: A response surface methodology study
Authors: Alcalá Sonia , Ocaña María Teresa , Cárdenas José Rafael , Miquel Miguel Ángel , Vilar Juan , Espínola Francisco , Moya Manuel 
Published: June 2016

The quality of the olives oil can be altered during their processing. This paper studies the influence that the washing of olive oils has on their alkyl esters content and on other quality parameters. A Central Composite Rotatable Design (CCRD) with five center points has been used to modify the factors, rotational frequency of the motor of the vertical centrifuge (between 34 and 47 Hz) and percentage of added water (between 6 and 34%). Results show that the content in alkyl esters of olive oils increases by the flow from the decanter to the vertical centrifuge. The use of water in the vertical centrifuge decreases the content in ethyl and methyl esters 0.8 and 0.6 mg/kg, respectively, per percentage unit of added water. The acidity, peroxide index, K232, chlorophyll, and carotenoid contents are slightly altered by the oil flow from the decanter to vertical centrifuge, but not by operating factors. K270, total polyphenols and orthodiphenols change with the speed of the vertical centrifuge, but water does not affect them. For the normal operation frequency of the centrifuge (50 Hz), K270 is increased about 14%, while the total polyphenols and orthodiphenols decrease by 27 and 62%, respectively.Practical applications: Quality control of olive oils (virgin and extra virgin).Olive‐oil production process: differences in the content of EE and TP between the vertical centrifuge way out and the decanter way out.
Catalytic Dry Reforming for Biomass‐Based Fuels Processing: Progress and Future Perspectives
Authors: Colmenares Juan Carlos , Colmenares Quintero Ramón Fernando , Pieta Izabela S. 
Published: June 2016

AbstractWe describe and review recent research on potential biomass‐derived fuels consisting of methanol, ethanol, butanol, and carboxylic acids. These fuels possess a volumetric energy densities of 15.6–22.7, 20.9–26.8, and 24.6 (levulinic acid) MJ L−, respectively. We recognize biomass as a valuable, sustainable, and economic fuel source in comparison to fossil fuels. First, we discuss, characterize, and compare all mentioned fuels. Second, we review recent research developments in the continuous pre‐processing for syngas production for biofuels production, specifically concentrating on dry reforming and the catalytic effects on the effluent and process efficiency. Finally, we discuss the future prospects and research needs to realize this technology on a global scale.
Acute and subacute toxicity of the polycyclic aromatic hydrocarbon 1-methylnaphthalene to the shallow-water coral Porites divaricata: Application of a novel exposure protocol
Authors: Renegar D. Abigail , Turner Nicholas R. , Riegl Bernhard M. , Dodge Richard E. , Knap Anthony H. , Schuler Paul A. 
Published: June 2016

Abstract

Previous research evaluating hydrocarbon toxicity to corals and coral reefs has generally focused on community-level effects, and results often are not comparable between studies because of variability in hydrocarbon exposure characterization and evaluation of coral health and mortality during exposure. Toxicity of the polycyclic aromatic hydrocarbon 1-methylnaphthalene to the coral Porites divaricata was assessed in a constant exposure toxicity test utilizing a novel toxicity testing protocol uniquely applicable to shallow-water corals, which considered multiple assessment metrics and evaluated the potential for post-exposure mortality and/or recovery. Acute and subacute effects (gross morphological changes, photosynthetic efficiency, mortality, and histologic cellular changes) were evaluated during pre-exposure (4 wk), exposure (48 h), and post-exposure recovery (4 wk) periods. Coral condition scores were used to determine a 48-h median effective concentration of 7442 μg/L. Significant physical and histological changes resulted from exposure to 640 μg/L and 5427 μg/L 1-methylnaphthalene, with a 1-d to 3-d delay in photosynthetic efficiency effects (ΔF/Fm). Pigmented granular amoebocyte area was found to be a potentially useful sublethal endpoint for this species. Coral mortality was used to estimate a 48-h median lethal concentration of 12 123 μg/L. Environ Toxicol Chem 2017;36:212–219. © 2016 SETAC
Effects of silver nanoparticles on the freshwater snail Physa acuta: The role of test media and snails’ life cycle stage
Authors: F. Gonçalves Sandra , D. Pavlaki Maria , Lopes Rafael , Hammes Julia , Gallego-Urrea Julián Alberto , Hassellöv Martin , Jurkschat Kerstin , Crossley Alison , Loureiro Susana 
Published: June 2016

Abstract

Silver nanoparticles (AgNPs) are widely used worldwide, most likely leading to their release into the environment and a subsequent increase of environmental concentrations. Studies of their deleterious effects on organisms is crucial to understand their environmental impacts. The freshwater snail Physa acuta was chosen to evaluate the potential deleterious effects of AgNPs and their counterpart AgNO3, through water-only exposures. The toxicity of AgNPs is greatly influenced by medium composition. Thus, 2 media were tested: artificial pond water (APW) and modified APW (adapted by removing calcium chloride). Acute tests (96 h) were performed with juvenile and adult snails in both media to assess lethality, and egg mass chronic tests were conducted with APW medium only to assess embryo viability and mortality, carried out until 90% hatching success was reached in the control. Acute toxicity increased with decreasing shell length for both silver forms (ion and nanoparticle); that is, juveniles were more sensitive than adults. Different test media led to dissimilar median lethal concentrations, with chloride playing an important role in toxicity, most likely by complexation with silver ions, which would reduce the bioavailability, uptake, and toxicity of silver. Chronic tests showed that hatching success was more sensitive to silver in the ionic form than in the particulate form. Different forms of silver, exposure media, and life cycle stages led to different patterns of toxicity, highlighting an impairment in the snails’ life cycle. Environ Toxicol Chem 2017;36:243–253. © 2016 SETAC
Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case‐Control Sequencing Studies
Authors: Larson Nicholas B. , McDonnell Shannon , Albright Lisa Cannon , Teerlink Craig , Stanford Janet , Ostrander Elaine A. , Isaacs William B. , Xu Jianfeng , Cooney Kathleen A. , Lange Ethan , Schleutker Johanna , Carpten John D. , Powell Isaac , Bailey‐Wilson Joan , Cussenot Olivier , Cancel‐Tassin Geraldine , Giles Graham , MacInnis Robert , Maier Christiane , Whittemore Alice S. , Hsieh Chih‐Lin , Wiklund Fredrik , Catolona William J. , Foulkes William , Mandal Diptasri , Eeles Rosalind , Kote‐Jarai Zsofia , Ackerman Michael J. , Olson Timothy M. , Klein Christopher J. , Thibodeau Stephen N. , Schaid Daniel J. 
Published: June 2016

ABSTRACTRare variants (RVs) have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional single‐marker methods for statistical analysis are underpowered for typical sequencing study sample sizes. Multimarker burden‐type approaches attempt to identify aggregation of RVs across case‐control status by analyzing relatively small partitions of the genome, such as genes. However, it is generally the case that the aggregative measure would be a mixture of causal and neutral variants, and these omnibus tests do not directly provide any indication of which RVs may be driving a given association. Recently, Bayesian variable selection approaches have been proposed to identify RV associations from a large set of RVs under consideration. Although these approaches have been shown to be powerful at detecting associations at the RV level, there are often computational limitations on the total quantity of RVs under consideration and compromises are necessary for large‐scale application. Here, we propose a computationally efficient alternative formulation of this method using a probit regression approach specifically capable of simultaneously analyzing hundreds to thousands of RVs. We evaluate our approach to detect causal variation on simulated data and examine sensitivity and specificity in instances of high RV dimensionality as well as apply it to pathway‐level RV analysis results from a prostate cancer (PC) risk case‐control sequencing study. Finally, we discuss potential extensions and future directions of this work.