bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells
Authors: Taguchi Ayumi , Koga Kaori , Kawana Kei , Makabe Tomoko , Sue Fusako , Miyashita Mariko , Yoshida Mitsuyo , Urata Yoko , Izumi Gentaro , Tkamura Masashi , Harada Miyuki , Hirata Tetsuya , Hirota Yasushi , Wada‐Hiraike Osamu , Fujii Tomoyuki , Osuga Yutaka 
Published: January 2016

ProblemResistance to apoptosis, together with inflammatory and invasive activity, contributes to the pathogenesis of endometriosis; therefore, approaches that can safely enhance apoptosis in endometriotic tissue are highly sought after as a means of managing the disease. Although resveratrol (RVT) is known to induce apoptosis or increase sensitivity to apoptotic stimuli in various cancer cell types, its effect on human endometriosis has remained uncertain. This study aimed to investigate whether RVT induces or enhances apoptosis in human endometriotic stromal cells (ESCs).Method of studyEndometriotic tissues were collected, during laparoscopies, from women affected by ovarian endometriosis. ESCs were prepared, cultured, and treated with RVT. Apoptosis was assessed by annexin V–PI staining. Survivin mRNA expression in ESCs was examined using RT‐PCR. ESCs were pre‐treated with or without RVT and then incubated with TNF‐α‐related‐apoptosis‐inducing ligand (TRAIL), which is a known pro‐apoptotic molecule.ResultsRVT alone did not induce apoptosis in ESCs. RVT significantly reduced survivin mRNA expression (P < 0.05). Pre‐treatment with RVT significantly enhanced TRAIL‐induced apoptosis (8.13 ± 0.83% (control) versus 29.19 ± 7.39% (pre‐treated with RVT), P < 0.05).ConclusionThis study indicates that RVT suppresses survivin expression and enhances TRAIL‐induced apoptosis in ESCs.
“We Are All Carrying Someone Else's Child!”: Relatedness and Relationships in Third‐Party Reproduction
Authors: Berend Zsuzsa 
Published: January 2016

ABSTRACTIn this article, I explore surrogates’ rich, diverse, and collective negotiations of relatedness and relationships on the largest U.S. surrogacy support website. Surrogates reconfigure existing kinship understandings and maintain that intent and love are firmer bases of parenthood than biogenetic connection. Increasing use of donor gametes contributes to the emphasis on desire to be parents. In gestational surrogacy, genetic relatedness between the child and the intended parents strengthens claim to parenthood but lack thereof does not call parenthood into question. Traditional surrogates’ biogenetic connection to the child they carry is never considered to be grounds for claims to motherhood. Surrogates and intended parents “do kinship” and consider the actions of kinship more consequential that its biological facts. In their accounts, desire for children is “natural” and the choice to raise them is understood as morally positive. Genetic facts, however, are understood as morally neutral. Surrogates and intended parents contend that surrogate babies belong to the parents who want them. Surrogates’ emphasis on chosen solidarity works to diminish the importance of genetic relatedness and helps them uphold the traditional boundaries of their own nuclear family and that of the intended parents. [kinship, assisted reproduction, U.S. surrogacy, family]
Totally laparoscopic gastrectomy for early gastric cancer accompanied by huge hiatal hernia: A case report
Authors: Hagiwara Chie , Yajima Kazuhito , Iwasaki Yoshiaki , Oohinata Ryouki , Yuu Ken , Ishiyama Satoshi , Amaki Misato , Nakano Daisuke , Yamaguchi Tatsuro , Matsumoto Hiroshi , Takahashi Keiichi 
Published: January 2016

AbstractWe herein present a case in which we used a totally laparoscopic approach for early gastric cancer accompanied by a huge hiatal hernia. An 80‐year‐old Japanese woman was referred with a chief complaint of dysphagia. A clinical diagnosis of early gastric cancer, T1b (SM) N0M0, stage IA, accompanied by hiatal hernia, was made. Distal gastrectomy with D1 plus lymphadenectomy was carried out. After the gastrectomy, the hernial sac was excised and the hernial orifice was closed. Reconstruction using the Roux‐en‐Y method was selected. The postoperative course was uneventful and she was discharged on postoperative day 10.
Laparoscopic abdominoperineal resection with lateral lymph node dissection for anorectal melanoma: A case report
Authors: Matsuda Kenji , Takifuji Katsunari , Hotta Tsukasa , Yokoyama Shozo , Ieda Junji , Iwamoto Hiromitsu , Tsumura Ayako , Kitadani Junya , Yamaue Hiroki 
Published: January 2016

AbstractBecause anorectal melanoma, a rare cancer with a poor outcome, does not respond well to local radiation therapy or systemic chemotherapy, surgery is the primary treatment. Herein, we present a case of anorectal melanoma with lateral and inguinal lymph node metastases. A 61‐year‐old woman presented with rectal bleeding. Colonoscopy revealed a black tumor with ulceration in the anorectum. A CT scan revealed an anorectal tumor with left lateral lymph node swelling and right inguinal lymph node swelling. We performed a laparoscopic abdominoperineal resection with lateral lymph node dissection and right inguinal lymph node dissection. One year after the initial operation, pulmonary metastases were observed, and pulmonary resection was performed. After the pulmonary resection, brain metastases developed, and surgical resection was performed. Despite the recurrence of disease, the patient has survived for 52 months since the initial surgery and continues to receive systemic chemotherapy.
Case of intra‐abdominal spindle cell tumor after laparoscopic resection of sigmoid colon cancer
Authors: Okada Naoya , Nakamura Fumitaka , Nanno Yoshihide , Takada Minoru , Ambo Yoshiyasu , Kishida Akihiro , Kashimura Nobuichi , Shinohara Toshiya 
Published: January 2016

AbstractWe herein report a rare case of a patient who developed a spindle cell tumor at the inferior mesenteric artery clipping site. A 58‐year‐old man underwent laparoscopy‐assisted sigmoid colectomy for sigmoid colon cancer. As follow‐up, CT scans were performed every 6 months after the primary surgery. At the 1‐year CT, an nodular soft tissue density mass measuring 54 mm in diameter was found in the mesentery. Although we initially suspected locoregional recurrence of the colon cancer resected 1 year earlier, PET‐CT showed that the tumor was unrelated to the previous cancer. During the subsequent laparotomy, the mass appeared to originate from the inferior mesenteric artery clipping site, and it adhered to the jejunum and the left ureter. We completely resected the tumor and part of the jejunum, which we separated from the abdominal aorta and left ureter. The tumor was histologically diagnosed of a spindle cell tumor. The patient has been free from recurrence since the surgery more than 4.5 years ago. Preoperative PET‐CT was helpful in ruling out local recurrence of colon cancer, which might have made palliative care a better option than surgical resection.
Successful treatment of a patient with an infected urachal remnant via single‐incision laparoscopic surgery: Report of a case
Authors: Nakamura Hiroyuki , Oshita Akihiko , Imamura Yuji , Sasaki Masaru , Kohyama Mohei , Tazaki Tatsuya , Sugiyama Yoichi , Daimaru Yutaka , Nakamitsu Atsushi 
Published: January 2016

AbstractWe report on a case of an infected urachal remnant successfully treated via a single‐incisional laparoscopic technique. An 18‐year‐old woman was diagnosed with an infected urachal remnant. The center of the umbilicus was pulled and inverted from the skin, and the cephalic side of the urachus was dissected from the umbilicus. A single‐incision laparoscopic technique employing ultrasonic coagulating shears was used to dissect the urachal remnant from the stump of the umbilicus to the caudal end. Single‐incision laparoscopic excision of the urachal remnant can be used successfully as a minimally invasive technique with optimal cosmetic outcomes.
Laparoscopic excision of abdominal wall desmoid tumor
Authors: Meshikhes Abdul‐Wahed , Al‐Zahrani Hana , Ewies Tarek 
Published: January 2016

AbstractOpen surgical resection is the mainstay treatment for desmoid tumors. Laparoscopic resection is rarely used and not well described in the literature. We report a case of a single, 35‐year‐old woman who presented with palpable abdominal wall desmoid tumor. The patient had had laparoscopic cholecystectomy 2 years earlier, and the tumor was at the insertion site of the right upper quadrant trocar. The diagnosis was made by a Tru‐Cut biopsy at another institution, after the lesion had increased in size and caused increased discomfort. The patient underwent successful laparoscopic resection of the tumor. This report aimed to promote laparoscopic resection of abdominal wall desmoid tumors, whenever feasible, and describe the laparoscopic technique. We believe this is the second case of laparoscopic excision of desmoid tumor reported in the English‐language literature.
Gray and white matter trajectories in patients with bipolar disorder
Authors: Sani Gabriele , Chiapponi Chiara , Piras Fabrizio , Ambrosi Elisa , Simonetti Alessio , Danese Emanuela , Janiri Delfina , Brugnoli Roberto , De Filippis Sergio , Caltagirone Carlo , Girardi Paolo , Spalletta Gianfranco 
Published: January 2016

ObjectivesFindings on brain structural abnormalities in patients with bipolar disorder (BP) are inconsistent and little is known about age‐related evolution of these changes. We employed a cross‐sectional, case–control study to compare structural age‐related brain trajectories in patients with BP and healthy control subjects (HC) over a period of approximately 50 years. The primary aim was to understand whether white (WM) and gray matter (GM) abnormalities are present from the beginning of the illness and how they change over time.MethodsSeventy‐eight patients with BP and 78 HC matched for age, gender, and educational level underwent a high‐resolution structural magnetic resonance imaging protocol. A voxel‐based morphometry (VBM) analysis was used to capture GM and WM differences between subjects with BP and HC. Factorial analysis of covariance was used to compare brain volume alterations at different ages between the groups.ResultsWe found an age‐related atrophy in GM and WM volumes both in patients with BP and HC. A main effect of diagnosis emerged in the posterior cingulate cortex bilaterally, in the right thalamus, in the cerebellum bilaterally, and in the left posterior limb of the internal capsule. No interaction between diagnosis and age emerged, indicating that the volumes of these areas were permanently reduced in subjects with BP throughout the entire age range under investigation.ConclusionsBrain alterations in patients with BP are present from the beginning of the illness and remain stable over time. All the affected areas are involved in mood and psychomotor control process. This suggests a possible neurodevelopmental involvement in the mechanism of BP.
A randomized controlled trial to determine the efficacy of a high carbohydrate and high protein ready‐to‐eat food product for weight loss
Authors: Fuller N. R. , Fong M. , Gerofi J. , Leung L. , Leung C. , Denyer G. , Caterson I. D. 
Published: January 2016

SummaryIncorporating meal replacements has been shown to produce a significantly greater weight loss than a conventional reduced calorie diet. Ready‐to‐eat conventional foods may also be effective in this role and provide additional benefit because of their palatability, acceptance and enjoyment and thus increase dietary compliance. This trial investigated the efficacy of a ready‐to‐eat food product (Vita‐Weat biscuit) that is both high in carbohydrate and high in protein as part of a diet prescription for weight loss in an overweight and obese population group. A total of 76 participants were randomized to a 6‐week weight loss intervention including the ready‐to‐eat food product (intervention group) or advice on the ‘Australian Guide to Healthy Eating’ (control group). Both groups lost approximately 2 kg weight which equated to a reduction in body mass index of 0.70 kg m−2. There was no significant difference in percentage weight loss from screening to 6 weeks between the two groups; mean difference for the intervention vs. control group: −0.20% (95% confidence interval: −0.96, 1.36); P = 0.73. Both diets were nutritionally matched and well‐accepted over the 6‐week period. This study shows that the inclusion of a ready‐to‐eat food product can be included as part of a dietary programme to achieve a clinically significant weight loss over a short period. This may have benefit when incorporated into an individual's meal plan intermittently to assist weight control. It also provides support for current public health nutritional guidelines as the participants in this study following such advice were also successful in achieving a clinically meaningful weight loss.
Lipomodelling for the management of symptomatic peristomal contour abnormalities: a pilot and feasibility study
Authors: Bonomi R. , Conway A. Z. , Rapisarda I. F. , Koulouglioti C. , Sajid M. S. , Betal D. , Kalra L. 
Published: January 2016

AbstractAimLipomodelling has been successfully used in reconstructive breast surgery but not yet in patients with permanent stomas.MethodA feasibility study of six patients with permanent stomas was undertaken. Patients underwent lipomodelling of the peristomal area. The number of leakages and quality of life were measured before and for 6 months after the procedure.ResultsAll patients reported an improvement in their stoma‐related quality of life and a reduction in the number of leakages experienced (mean: 2.25 leakages/24 h before lipomodelling and 0.5 leakages/24 h after lipomodelling).ConclusionLipomodelling appears to be an effective method to reduce stoma leakages caused by peristomal skin contour abnormalities.
Diffuse alveolar hemorrhage associated with low molecular weight heparin and dual anti‐platelet therapy after percutaneous coronary intervention
Authors: Yıldırım Fatma , Kara İskender , Okuyan Hızır , Abacı Adnan , Türkoğlu Melda , Aygencel Gülbin 
Published: January 2016

AbstractA 54‐year‐old man underwent percutaneous coronary intervention (PCI) and two stents were placed on left anterior coronary artery and circumflex artery. Low molecular weight heparin (LMWH) together with ticagrelor 90 mg twice a day and acetylsalicylic acid (Aspirin) were started after PCI due to high risk of stent thrombosis. On the fourth day of patient's follow‐up in the intensive care unit (ICU), bloody secretion was started from endotracheal tube. Hemoglobin dropping, bilateral infiltration on the chest X‐ray and bleeding from lung were diagnosed as diffuse alveolar hemorrhage (DAH). Apart from LMWH and antiplatelet therapies with aspirin and ticagrelor, there were no other identified risk factors for DAH. As far as we know, our report is the first case of DAH caused by LMWH and dual anti‐platelet therapy including ticagrelor.
No survival benefit to gaining private health insurance coverage for post‐lung transplant care in adults with cystic fibrosis
Authors: Tumin Dmitry , Foraker Randi E. , Tobias Joseph D. , Hayes Don 
Published: January 2016

AbstractThe use of public insurance is associated with diminished survival in patients with cystic fibrosis (CF) following lung transplantation. No data exist on benefits of gaining private health insurance for post‐transplant care among such patients previously using public insurance. The United Network for Organ Sharing database was used to identify first‐time lung transplant recipients participating in Medicare or Medicaid, diagnosed with CF, and transplanted between 2005 and 2015. Survival outcomes were compared between recipients gaining private insurance after transplantation and those maintaining public coverage throughout follow‐up. Since implementation of the lung allocation score, 575 adults with CF received lung transplantation funded by Medicare or Medicaid and contributed data on insurance status post‐transplant. There were 128 (22%) patients who gained private insurance. Multivariable analysis of time‐varying insurance status found no survival benefit of gaining private insurance (HR = 0.822; 95% CI = 0.525, 1.286; p = 0.390). Further analysis demonstrated that resuming public insurance coverage was detrimental, relative to gaining and keeping private insurance (HR = 2.315; 95% CI = 1.020, 5.258; p = 0.045). Survival disadvantages of lung transplant recipients with CF who have public health insurance were not ameliorated by a switch to private coverage for post‐transplant care.
Cost‐effectiveness of whole‐body bone scans in the pre‐liver transplant assessment of patients with hepatocellular carcinoma in Southern Brazil
Authors: Rodríguez Santiago , Balbinotto Neto Giácomo , Kiss Guillermo , Brandão Ajacio ,   the Liver Transplantation Group
Published: January 2016

AbstractBackgroundBone metastases (BM) are rare in patients with early‐stage hepatocellular carcinoma (HCC). In many centers, liver transplantation (LTx) policies require patients withHCCto undergo bone scans (BSs).MethodsWe retrospectively assessed the benefit ofBSfor patients with a diagnosis ofHCCwait‐listed forLTx.ResultsBSwas performed in 259 of 328 patients (78.9%) and was suggestive ofBMin only one (0.4%). At follow‐up, 276 patients had receivedLTx, of whom 207 had undergoneBS. Histopathological examination of explants failed to confirm the presence ofHCCin 20 patients from theBSgroup. The survival and recurrence rates of the 187 patients with confirmedHCCin the explant who underwentBSas part of pre‐LTx assessment and 69 patients who did not undergoBSwere compared. The one‐ and five‐yr post‐transplant survival rates were 81% and 69%, respectively, in theBSgroup vs. 78% and 62%, respectively, in patients who did not undergoBS(p = 0.25). The one‐ and five‐yr post‐LTx recurrence rates were 4.8% and 10.7%, respectively, in theBSgroup vs. 2.9% and 10.1%, respectively, in patients who did not undergoBS(p = 0.46).ConclusionsBSgenerated expenditures of US$39 296 and was not cost‐effective.
Serial perfusion in native lungs in patients with idiopathic pulmonary fibrosis and other interstitial lung diseases after single lung transplantation
Authors: Sokai Akihiko , Handa Tomohiro , Chen Fengshi , Tanizawa Kiminobu , Aoyama Akihiro , Kubo Takeshi , Ikezoe Kohei , Nakatsuka Yoshinari , Oguma Tsuyoshi , Hirai Toyohiro , Nagai Sonoko , Chin Kazuo , Date Hiroshi , Mishima Michiaki 
Published: January 2016

AbstractBackgroundLung perfusions after single lung transplantation (SLT) have not been fully clarified in patients with interstitial lung disease (ILD). The present study aimed to investigate temporal changes in native lung perfusion and their associated clinical factors in patients with ILD who have undergone SLT.MethodsEleven patients were enrolled. Perfusion scintigraphy was serially performed up to 12 months after SLT. Correlations between the post‐operative perfusion ratio in the native lung and clinical parameters, including pre‐operative perfusion ratio and computed tomography (CT) volumetric parameters, were evaluated.ResultsOn average, the perfusion ratio of the native lung was maintained at approximately 30% until 12 months after SLT. However, the ratio declined more significantly in idiopathic pulmonary fibrosis (IPF) than in other ILDs (p = 0.014). The perfusion ratio before SLT was significantly correlated with that at three months after SLT (ρ = 0.64, p = 0.048). The temporal change of the perfusion ratio in the native lung did not correlate with those of the CT parameters.ConclusionThe pre‐operative perfusion ratio may predict the post‐operative perfusion ratio of the native lung shortly after SLT in ILD. Perfusion of the native lung may decline faster in IPF compared with other ILDs.
Effects of Remanufacturable Product Design on Market Segmentation and the Environment
Authors: Shi Tianqin , Gu Wenjun , Chhajed Dilip , Petruzzi Nicholas C. 
Published: January 2016

ABSTRACTDespite documented benefits of remanufacturing, many manufacturers have yet to embrace the idea of tapping into remanufactured‐goods markets. In this article, we explore this dichotomy and analyze the effect of remanufacturable product design on market segmentation and product and trade‐in prices by studying a two‐stage profit‐maximization problem in which a price‐setting manufacturer can choose whether or not to open a remanufactured‐goods market for its product. Our results suggest that it is optimal for a manufacturer to design a remanufacturable product when the value‐added from remanufacturing is relatively high but product durability is relatively low and innovation is nominal. In addition, we find that entering a remanufactured‐goods market in and of itself does not necessarily translate into environmental friendliness. On the one hand, the optimal trade‐in program could result in low return and/or remanufacturing rates. On the other hand, a low price for remanufactured products could attract higher demand and thereby potentially result in more damage to the environment. Meanwhile, external restrictions imposed on total greenhouse gas emissions draw criticism in their own right because they risk stifling growth or reducing overall consumer welfare. Given these trade‐offs, we therefore develop and compare several measures of environmental efficiency and conclude that emissions per revenue can serve as the best proxy for emissions as a metric for measuring overall environmental stewardship.
Comparing risks of cerebral palsy in births between Australian Indigenous and non‐Indigenous mothers
Authors: Blair Eve , Watson Linda , O'Kearney Emily , D'Antoine Heather , Delacy Michael J ,   the Australian Cerebral Palsy Register Group
Published: January 2016

AimTo compare proportions of live births subsequently described as having cerebral palsy (CP), the distributions of associated impairments, and the causes of postneonatal CP between Aboriginal and Torres Strait Islander (Indigenous) and non‐Indigenous populations in Australia.MethodData from statutory birth records and CP registers for the 1996 to 2005 birth cohort in Queensland, Western Australia, and the Northern Territory were stratified by Indigenous status and whether the CP was acquired pre/perinatally or postneonatally. Relative risks associated with Indigenous status were estimated and the distributions of causes of postneonatal CP compared.ResultsIndigenous births had a relative risk of 4.9 (95% confidence interval [CI] 3.0–7.9) for postneonatal CP but only of 1.42 (95% CI 1.2–1.7) for pre/perinatal CP. Almost half of postneonatal CP in Indigenous infants resulted from infection, whereas for non‐Indigenous infants the most frequent cause was cerebrovascular accident. The impairments of Indigenous CP and of postneonatally acquired CP tended to be more numerous and more severe.InterpretationIndigenous children are at significantly greater risk of CP, particularly postneonatal CP. The predominant cause of postneonatal CP in non‐Indigenous children has shifted to cerebrovascular accident over time; however, infections followed by head injury are still the most frequent causes in Indigenous infants.