bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases
Authors: Dubois Sydney , Viailly Pierre-Julien , Bohers Elodie , Bertrand Philippe , Ruminy Philippe , Marchand Vinciane , Maingonnat Catherine , Mareschal Sylvain , Picquenot Jean-Michel , Penther Dominique , Jais Jean-Philippe , Tesson Bruno , Peyrouze Pauline , Figeac Martin , Desmots Fabienne , Fest Thierry , Haioun Corinne , Lamy Thierry , Copie-Bergman Christiane , Fabiani Bettina , Delarue Richard , Peyrade Frédéric , André Marc , Ketterer Nicolas , Leroy Karen , Salles Gilles , Molina Thierry J. , Tilly Hervé , Jardin Fabrice 
Published: December 2016

AbstractPurpose: MYD88 mutations, notably the recurrent gain-of-function L265P variant, are a distinguishing feature of activated B-cell like (ABC) diffuse large B-cell lymphoma (DLBCL), leading to constitutive NFκB pathway activation. The aim of this study was to examine the distinct genomic profiles of MYD88-mutant DLBCL, notably according to the presence of the L265P or other non-L265P MYD88 variants.Experimental Design: A cohort of 361 DLBCL cases (94 MYD88 mutant and 267 MYD88 wild-type) was submitted to next-generation sequencing (NGS) focusing on 34 genes to analyze associated mutations and copy number variations, as well as gene expression profiling, and clinical and prognostic analyses.Results: Importantly, we highlighted different genomic profiles for MYD88 L265P and MYD88 non-L265P–mutant DLBCL, shedding light on their divergent backgrounds. Clustering analysis also segregated subgroups according to associated genetic alterations among patients with the same MYD88 mutation. We showed that associated CD79B and MYD88 L265P mutations act synergistically to increase NFκB pathway activation, although the majority of MYD88 L265P–mutant cases harbors downstream NFκB alterations, which can predict BTK inhibitor resistance. Finally, although the MYD88 L265P variant was not an independent prognostic factor in ABC DLBCL, associated CD79B mutations significantly improved the survival of MYD88 L265P–mutant ABC DLBCL in our cohort.Conclusions: This study highlights the relative heterogeneity of MYD88-mutant DLBCL, adding to the field's knowledge of the theranostic importance of MYD88 mutations, but also of associated alterations, emphasizing the usefulness of genomic profiling to best stratify patients for targeted therapy. Clin Cancer Res; 23(9); 2232–44. ©2016 AACR.
Predicting MEK Inhibitor Response in Lung Cancer: A Proper Signature Is Required
Authors: Xue Yaohua , Lito Piro 
Published: December 2016

Abstract
The ERK signaling pathway is one of the most commonly deregulated pathways in cancer. Assays that accurately measure ERK signaling output in clinical specimens would be extremely helpful not only in determining the pharmacodynamic effects of drug treatment but also in selecting those patients most likely to respond to therapy. Clin Cancer Res; 23(6); 1365–7. ©2016 AACR.
See related article by Brant et al., p. 1471
Bortezomib Relieves Immune Tolerance in Nasopharyngeal Carcinoma via STAT1 Suppression and Indoleamine 2,3-Dioxygenase Downregulation
Authors: Jiang Guan-Min , Wang Hong-Sheng , Du Jun , Ma Wei-Feng , Wang Hui , Qiu Yu , Zhang Qiu-Gui , Xu Wei , Liu Hui-Fang , Liang Jian-Ping 
Published: December 2016

Abstract
Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC). Patients with intermediate and advanced stage NPC receiving only radiotherapy have limited survival, so newer immunotherapeutic approaches are sought. The major impediment to better clinical outcomes is tumor immune tolerance. Indoleamine 2,3-dioxygenase (IDO), an IFNγ-inducible enzyme, is a major inducer of immune tolerance during tumor development; therefore, inhibition of the IDO pathway is an important modality for cancer treatment. We show that bortezomib, a proteasomal inhibitor, inhibited the pathways leading to STAT1 and IRF-1 activation, both of which are necessary for IDO expression. Bortezomib downregulated IFNγ-induced IDO expression via inhibition of STAT1 phosphorylation and nuclear translocation, thereby suppressing STAT1-driven IDO transcription in NPC cells. Bortezomib also promoted IκB-α phosphorylation-ubiquitination, which released NF-κB from IκB-α. However, the released NF-κB could not enter the nucleus to conduct its biological effects and accumulated in the cytoplasm. Negative feedback inhibited the transcription of NF-κB, which is important for activating IRF-1 expression. IDO expression is regulated by two important transcription factor binding sites, ISREs, which bind STAT1 and IRF-1, and GASs, which binds STAT1. Bortezomib upregulated IRF-1 protein by inhibiting its proteasome-dependent degradation, but it also inhibited STAT1 phosphorylation, which directly inhibited the activation of GAS and indirectly inhibited the activation of ISRE, which needs both STAT1 and IRF-1. These discoveries provide a mechanism for the antitumor action of bortezomib and have implications for the development of clinical cancer immunotherapy for preventing and treating NPC. Cancer Immunol Res; 5(1); 42–51. ©2016 AACR.
Antropófagos devorados e seus desencontros: da “formação” à “inserção” da literatura brasileira
Authors: Melo Alfredo Cesar Barbosa de 
Published: December 2016

O artigo se propõe a pensar a literatura brasileira a partir do paradigma comparativista da “inserção”. Para fixar suas características, faço contraponto ao paradigma hegemônico da formação. Argumento que os dois paradigmas partem de pressupostos muito diferentes no que se refere à presença da cultura brasileira no mundo. A ideia de formação presume uma relação derivativa diante da Europa, vista como modelo a ser emulado. Outra dinâmica de poder surge com a inserção da literatura brasileira em países africanos, produzindo representações dentre os letrados africanos que igualavam o Brasil ao país deles. O artigo procura tirar consequências das diferenças entre os dois paradigmas.
Pedal Edema as an Indicator of Early Heart Failure in the Community
Authors: Yeboah Joseph , Bertoni Alain , Qureshi Waqas , Aggarwal Shivani , Lima Joao A.C. , Kawel-Boehm Nadine , Bluemke David A. , Shah Sanjiv J. 
Published: December 2016

Background—
The prevalence of pedal edema (PE) and its associations with abnormal cardiac structure/function, natriuretic peptides, and incident heart failure (HF) is unknown, especially in community-dwelling adults without a history of cardiovascular disease.

Methods and Results—
Out of 5004 MESA (Multiethnic Study of Atherosclerosis) participants who had cardiac magnetic resonance imaging, 4196 had complete data and were included in this analysis (3501 for the right ventricle analysis). Logistic regression and Cox proportional hazard analyses were used to assess the associations among self-reported PE, 2-pillow orthopnea, paroxysmal nocturnal dyspnea, left and right ventricular structure and function, natriuretic peptide levels, and incident HF. PE was present in 28% of the participants. PE was not associated with overt left or right ventricular systolic dysfunction (ejection fraction <50%). PE was associated with 2-pillow orthopnea (odds ratio 1.66; 95% confidence interval [CI], 1.30–2.12), paroxysmal nocturnal dyspnea (odds ratio 1.95; 95% CI, 1.55–2.44), and abnormal N-terminal pro-B-type natriuretic peptide levels (defined as >400 pg/mL; odds ratio 1.80; 95% CI, 1.21–2.68) in adjusted models. After a mean of 10.2 years of follow-up, 184/4196 (4.4%) participants had an adjudicated incident HF hospitalization. PE was associated with incident HF hospitalization in models adjusted for age, sex, and race (hazard ratio 1.44; 95% CI, 1.05–1.97). This association persisted after adding additional covariates, including comorbidities, baseline left ventricular ejection fraction, and antecedent myocardial infarction (hazard ratio 1.43; 95% CI, 1.02–1.99). The association of PE with incident HF was attenuated by further adjustment for N-terminal pro-B-type natriuretic peptide.

Conclusions—
PE is prevalent in community-dwelling adults without clinically recognized cardiovascular disease and associated with future hospitalized HF.
Early Trajectory of Stroke Severity Predicts Long-Term Functional Outcomes in Ischemic Stroke Subjects
Authors: Sajobi Tolulope T. , Menon Bijoy K. , Wang Meng , Lawal Oluwaseyi , Shuaib Ashfaq , Williams David , Poppe Alexandre Y. , Jovin Tudor G. , Casaubon Leanne K. , Devlin Thomas , Dowlatshahi Dar , Fanale Chris , Lowerison Mark W. , Demchuk Andrew M. , Goyal Mayank , Hill Michael D. 
Published: December 2016

Background and Purpose—
The trajectory of neurological improvement after stroke treatment is clinically likely to be an important prognostic signal. We compared the accuracy of early longitudinal National Institutes of Health Stroke Scale (NIHSS) measurement versus other early markers of stroke severity post treatment in predicting subjects’ 90-day stroke outcome.

Methods—
Data are from the Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with ESCAPE trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times). Stroke severity was assessed at baseline, 1, 2, 5, 30, and 90 days. Subjects’ functional outcome was assessed using the modified Rankin Scale at baseline, 30 days, and 90 days. Group-based trajectory model was used to identify distinct subgroups of longitudinal trajectories of NIHSS measured over the first 2, 5, and 30 days. The accuracy of baseline NIHSS, infarct volume, 24-hour change in NIHSS, infarct volume, and disease severity trajectory subgroups in predicting 90-day stroke outcome were assessed using logistic regression analysis.

Results—
Group-based trajectory model of the 2-day longitudinal NIHSS data revealed 3 distinct subgroups of NIHSS trajectories—large improvement (41.6%), minimal improvement (31.1%), and no improvement (27.3%) subgroups. Individuals in the large improvement group were more likely were more likely to exhibit good outcomes after 90 days than those in the minimal improvement or no improvement subgroup. Among candidate predictors, the 2-day trajectory subgroup variable was the most accurate in predicting 90-day modified Rankin Scale at 84.5%.

Conclusions—
Early trajectory of neurological improvement defined by 2-day longitudinal NIHSS data predicts functional outcomes with greater accuracy than other common variables.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01778335.
Policy Space under the Second Clause of gatt Article xx(g)
Authors: Wu Yingying 
Published: December 2016

The demand for rare earths elements (rees), which are essential inputs for some electronic consumer products and crucial to the development of high-tech products, has grown rapidly. As the major supplier of rees, China’s rees policy has affected global markets significantly. Countries have pursued ways to address the shortfall and high prices of rees. The Appellant Body (ab) ruled that China violated its wto obligations in the dispute regarding China’s restrictions on the export of rees.
Nevertheless, there is potential policy space preserved for national interests from the Appellant Body’s viewpoint, which rejected the Panel’s view that the burden of policies must be evenly distributed between domestic consumers and foreign consumers. By focusing on the second clause of gatt Article xx(g), this essay analyzes the wto ruling and its impact on China’s rees policy, as well as other factors that play roles in China’s policy choices.
Methods for Computing the Boiling Temperature of Water at Varying Pressures
Authors: Miller Sam 
Published: December 2016

Abstract
Boiling is an extreme form of evaporation that occurs when the saturation vapor pressure is equal to the total atmospheric pressure. This paper computes boiling temperature by four different methods and compares the results to data provided in the CRC Handbook of Physics and Chemistry. The first method utilizes a constant value for the latent heat of vaporization (lυ) in the Clausius–Clapeyron equation, and the second method uses a previously published temperature-dependent linear function for lυ. A third method is suggested that begins by deriving a new second-order function for lυ, and then applies this function in an error-reduction loop to determine boiling temperature as a function of pressure. This method for computing boiling temperature shows a mean bias of 0.31°C between mean sea level pressure and 100 hPa and a mean error of less than a tenth of a percent, which is a significant improvement over both of the first two methods. The fourth method uses a fifth-order polynomial, eliminating lυ and making pressure the independent variable, which is used to compute boiling temperature with a mean bias of 0.25°C and a mean error of 0.09% for pressures between mean sea level pressure and 100 hPa.
What Can We Conclude about the Real Aspect Ratios of Ice Particle Aggregates from Two-Dimensional Images?
Authors: Jiang Zhiyuan , Oue Mariko , Verlinde Johannes , Clothiaux Eugene E. , Aydin Kultegin , Botta Giovanni , Lu Yinghui 
Published: December 2016

AbstractA simple numerical experiment was performed to investigate the result published in many papers that measurements indicate that aggregates may be well represented as oblate spheroids with mean aspect ratio (semiminor axis to semimajor axis length) of 0.6. The aspect ratio measurements are derived from two-dimensional projections of complex three-dimensional aggregates. Here, aggregates were modeled as ellipsoids with semiprincipal axes of length a, b, and c, which include oblate spheroids (a = b) as a class, and the projected aspect ratios of large numbers of two-dimensional projections of them were sampled. When sampling oblate spheroids with aspect ratio 0.6 over random orientations, the mean projected aspect ratio is 0.746. A mean projected aspect ratio of 0.6 is obtained for an oblate spheroid with aspect ratio of 0.33. When sampling randomly oriented ellipsoids with semiminor axes (b, c) varying from 0.10 to 1.00 in steps of 0.01, representing many complex shapes, the mean projected aspect ratio is 0.595, close to the measured mean projected aspect ratio of aggregates of 0.6. These experiments demonstrate that the conclusion one may safely draw from the projected aspect ratio measurements is that the mean aspect ratio of aggregates is lower than 0.6. Moreover, the projected aspect ratio distributions from measurements suggest a mixture of aggregate shapes, rather than only oblate spheroids as is often assumed.
Single Precision in Weather Forecasting Models: An Evaluation with the IFS
Authors: Váňa Filip , Düben Peter , Lang Simon , Palmer Tim , Leutbecher Martin , Salmond Deborah , Carver Glenn 
Published: December 2016

AbstractEarth’s climate is a nonlinear dynamical system with scale-dependent Lyapunov exponents. As such, an important theoretical question for modeling weather and climate is how much real information is carried in a model’s physical variables as a function of scale and variable type. Answering this question is of crucial practical importance given that the development of weather and climate models is strongly constrained by available supercomputer power. As a starting point for answering this question, the impact of limiting almost all real-number variables in the forecasting mode of ECMWF Integrated Forecast System (IFS) from 64 to 32 bits is investigated. Results for annual integrations and medium-range ensemble forecasts indicate no noticeable reduction in accuracy, and an average gain in computational efficiency by approximately 40%. This study provides the motivation for more scale-selective reductions in numerical precision.
Investigating the Use of Ensemble Variance to Predict Observation Error of Representation
Authors: Satterfield Elizabeth , Hodyss Daniel , Kuhl David D. , Bishop Craig H. 
Published: December 2016

AbstractData assimilation schemes combine observational data with a short-term model forecast to produce an analysis. However, many characteristics of the atmospheric states described by the observations and the model differ. Observations often measure a higher-resolution state than coarse-resolution model grids can describe. Hence, the observations may measure aspects of gradients or unresolved eddies that are poorly resolved by the filtered version of reality represented by the model. This inconsistency, known as observation representation error, must be accounted for in data assimilation schemes. In this paper the ability of the ensemble to predict the variance of the observation error of representation is explored, arguing that the portion of representation error being detected by the ensemble variance is that portion correlated to the smoothed features that the coarse-resolution forecast model is able to predict. This predictive relationship is explored using differences between model states and their spectrally truncated form, as well as commonly used statistical methods to estimate observation error variances. It is demonstrated that the ensemble variance is a useful predictor of the observation error variance of representation and that it could be used to account for flow dependence in the observation error covariance matrix.
A LAMP–HRRR MELD for Improved Aviation Guidance
Authors: Glahn Bob , Schnapp Adam D. , Ghirardelli Judy E. , Im Jung-Sun 
Published: December 2016

Abstract
Localized Aviation MOS Program (LAMP) forecasts of ceiling height, visibility, wind, and other weather elements of interest to the aviation community have been produced and put into the National Digital Guidance Database (NDGD) since 2006. The High Resolution Rapid Refresh (HRRR) model is now producing explicit forecasts of ceiling height and visibility computed by algorithms based on variables directly forecasted by the HRRR. The Meteorological Development Laboratory has improved the LAMP ceiling and visibility forecasts by combining these two sources of information into a LAMP–HRRR MELD. The new forecasts show improvement over the original LAMP and particularly over the HRRR and persistence in terms of bias, threat score, and the Gerrity score. This paper explains how the MELD is produced and shows selected verification and example forecasts. A new guidance product based on this work will be made available to partners and customers.
A Systematic Review of Interventions to Enhance Healthy Lifestyle Behaviors in Adolescents Delivered via Mobile Phone Text Messaging
Authors: Loescher Lois J. , Rains Stephen A. , Kramer Sandra S. , Akers Chelsie , Moussa Renee 
Published: December 2016

Objective: To systematically review healthy lifestyle interventions targeted to adolescents and delivered using text messaging (TM). Data Source: PubMed, Embase, CINAHL, PsycINFO, and Web of Science databases. Study Inclusion Criteria: Research articles published during 2011 to 2014; analyses focused on intervention targeting adolescents (10-19 years), with healthy lifestyle behaviors as main variables, delivered via mobile phone-based TM. Data Extraction: The authors extracted data from 27 of 281 articles using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method. Data Synthesis: Adolescent and setting characteristics, study design and rigor, intervention effectiveness, challenges, and risk of bias. Results: Across studies, 16 (59.3%) of 27 included non-Caucasians. The gender was split for 22 (81.5%) of 27 studies. Thirteen studies were randomized controlled trials. There was heterogeneity among targeted conditions, rigor of methods, and intervention effects. Interventions for monitoring/adherence (n = 8) reported more positive results than those for health behavior change (n = 19). Studies that only included message delivered via TM (n = 14) reported more positive effects than studies integrating multiple intervention components. Interventions delivered using TM presented minimal challenges, but selection and performance bias were observed across studies. Conclusion: Interventions delivered using TM have the potential, under certain conditions, to improve healthy lifestyle behaviors in adolescents. However, the rigor of studies varies, and established theory and validated measures have been inconsistently incorporated.
Prediction of abdominal aortic aneurysm calcification by means of variation of high-sensitivity C-reactive protein
Authors: Garrafa Emirena , Giacomelli Alessio , Ravanelli Marco , Dell’Era Patrizia , Peroni Michele , Zanotti Camilla , Caimi Luigi , Bonardelli Stefano 
Published: December 2016

Objective Abdominal aortic aneurysms are a major cause of death in developed countries, and thrombus and calcification of the aneurysm have been linked to increased complications. This study was conducted in order to identify the biochemical marker associated to the presence of intraluminal thrombus or calcification progression of the aneurysm. Design Several clinical laboratory parameters were measured in patients with abdominal aortic aneurysms, in particular those already demonstrated to be related to the pathology, such as lipoprotein (a), white blood cell count, fibrinogen and high-sensitivity C-reactive protein. Most of the patients were analysed for the presence of thrombus or aorta calcification using CT angiography. Results Unlike previous findings, we found no association between intraluminal thrombus formation and lipoprotein (a), but we evidenced that patients with lower grade of calcification tend to have higher plasma high-sensitivity C-reactive protein values compared with patients with a higher degree of calcification. Instead, no association was found with either white blood cell count or fibrinogen level. Conclusions This study suggests that high-sensitivity C-reactive protein is a useful biomarker to assess the evolution of calcification and could be used in triaging patients to identify those who should undergo a rapid imaging, thus allowing prompt initiation of treatment or rule-out suspicious patients from non-essential imaging repetition.
Jugular venous reflux on magnetic resonance angiography and radionuclide venography
Authors: Fushimi Yasutaka , Okada Tomohisa , Okuchi Sachi , Yamamoto Akira , Kanagaki Mitsunori , Fujimoto Koji , Togashi Kaori 
Published: December 2016

Background The relationship between the signal from retrograde venous flow on magnetic resonance angiography (MRA) and retrograde upward flow from the left brachiocephalic vein has not been explored. Purpose To reveal the frequency of jugular venous reflux using MRA and nuclear venography in patients being evaluated for cerebral volume and blood flow. Material and Methods A total of 229 patients with cognitive disturbance who had undergone brain magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) on the same day to evaluate cerebral blood flow were evaluated. Jugular venous reflux was measured on MRA and nuclear venography, which was conducted just after injection of N-isopropyl-123I-p-iodoamphetamine for the SPECT study. Results MRA showed jugular reflux in seven patients on the right side, and in 22 on the left. Nuclear venography showed jugular reflux in six patients on the right side, and in 20 on the left. Conclusion Jugular venous reflux was observed mostly on the left side. Retrograde flow was observed on both MRA and nuclear venography in half of the cases, with the rest only on one of the modalities.