bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of Calcium Signal and Leukotriene C4Release in Mast Cells Network Induced by Mechanical Stimuli and Modulated by Interstitial Fluid Flow
Authors: Yao Wei , Yang Hongwei , Li Yabei , Ding Guanghong 
Published: December 2015

AbstractMast cells (MCs) play an important role in the immune system. Through connective tissues, mechanical stimuli activate intracellular calcium signaling pathways, induce a variety of mediators including leukotriene C4(LTC4) release, and affect MCs’ microenvironment. This paper focuses on MCs’ intracellular calcium dynamics and LTC4release responding to mechanical stimuli, explores signaling pathways in MCs and the effect of interstitial fluid flow on the transport of biological messengers and feedback in the MCs network. We use a mathematical model to show that (i) mechanical stimuli including shear stress induced by interstitial fluid flow can activate mechano-sensitive (MS) ion channels on MCs’ membrane and allow Ca2+entry, which increases intracellular Ca2+concentration and leads to LTC4release; (ii) LTC4in the extracellular space (ECS) acts on surface cysteinyl leukotriene receptors (LTC4R) on adjacent cells, leading to Ca2+influx through Ca2+release-activated Ca2+(CRAC) channels. An elevated intracellular Ca2+concentration further stimulates LTC4release and creates a positive feedback in the MCs network. The findings of this study may facilitate our understanding of the mechanotransduction process in MCs induced by mechanical stimuli, contribute to understanding of interstitial flow-related mechanobiology in MCs network, and provide a methodology for quantitatively analyzing physical treatment methods including acupuncture and massage in traditional Chinese medicine (TCM).
Elastic Waves in Generalized Thermo-Piezoelectric Transversely Isotropic Circular Bar Immersed in Fluid
Authors: Ponnusamy Palaniyandi 
Published: December 2015

AbstractIn this paper, a mathematical model is developed to study the wave propagation in an infinite, homogeneous, transversely isotropic thermo-piezoelectric solid bar of circular cross-sections immersed in inviscid fluid. The present study is based on the use of the three-dimensional theory of elasticity. Three displacement potential functions are introduced to uncouple the equations of motion and the heat and electric conductions. The frequency equations are obtained for longitudinal and flexural modes of vibration and are studied based on Lord-Shulman, Green-Lindsay and Classical theory theories of thermo elasticity. The frequency equations of the coupled system consisting of cylinder and fluid are developed under the assumption of perfect-slip boundary conditions at the fluid-solid interfaces, which are obtained for longitudinal and flexural modes of vibration and are studied numerically for PZT-4 material bar immersed in fluid. The computed non-dimensional frequencies are compared with Lord-Shulman, Green-Lindsay and Classical theory theories of thermo elasticity for longitudinal and flexural modes of vibrations. The dispersion curves are drawn for longitudinal and flexural modes of vibrations. Moreover, the dispersion of specific loss and damping factors are also analyzed for longitudinal and flexural modes of vibrations.
A Comparative Study of Finite Element and Finite Difference Methods for Two-Dimensional Space-Fractional Advection-Dispersion Equation
Authors: Pang Guofei , Chen Wen , Sze Kam Yim 
Published: December 2015

AbstractThe paper makes a comparative study of the finite element method (FEM) and the finite difference method (FDM) for two-dimensional fractional advection-dispersion equation (FADE) which has recently been considered a promising tool in modeling non-Fickian solute transport in groundwater. Due to the non-local property of integro-differential operator of the space-fractional derivative, numerical solution of FADE is very challenging and little has been reported in literature, especially for high-dimensional case. In order to effectively apply the FEM and the FDM to the FADE on a rectangular domain, a backward-distance algorithm is presented to extend the triangular elements to generic polygon elements in the finite element analysis, and a variable-step vector Grünwald formula is proposed to improve the solution accuracy of the conventional finite difference scheme. Numerical investigation shows that the FEM compares favorably with the FDM in terms of accuracy and convergence rate whereas the latter enjoys less computational effort.
Stability Analysis and Order Improvement for Time Domain Differential Quadrature Method
Authors: Wang Fangzong , Liao Xiaobing , Xie Xiong 
Published: December 2015

AbstractThe differential quadrature method has been widely used in scientific and engineering computation. However, for the basic characteristics of time domain differential quadrature method, such as numerical stability and calculation accuracy or order, it is still lack of systematic analysis conclusions. In this paper, according to the principle of differential quadrature method, it has been derived and proved that the weighting coefficients matrix of differential quadrature method meets the important V-transformation feature. Through the equivalence of the differential quadrature method and the implicit Runge-Kutta method, it has been proved that the differential quadrature method is A-stable and s-stage s-order method. On this basis, in order to further improve the accuracy of the time domain differential quadrature method, a class of improved differential quadrature method of s-stage 2s-order has been proposed by using undetermined coefficients method and Padé approximations. The numerical results show that the proposed differential quadrature method is more precise than the traditional differential quadrature method.
The origins of pottery in East Asia: updated analysis (the 2015 state-of-the-art)
Authors: Kuzmin Yaroslav 
Published: December 2015

Recent developments related to the emergence of pottery in East Asia and neighbouring regions are presented. According to a critical evaluation of the existing evidence, the oldest centres with pottery in East Asia are situated in South China (dated to c. 18 000 calBP), the Japanese Islands (c. 16 700 calBP), and the Russian Far East (c. 15 900 calBP). It is most likely that pottery-making appeared in these regions independently of each other. In Siberia, the earliest pottery now known isfrom the Transbaikal region (dated to c. 14 000 calBP). However, it did not influence the more westerly parts of Siberia in terms of the origin and spread of pottery-making.
Salt exploitation in the later prehistory of the Carpathian Basin
Authors: Harding Anthony 
Published: December 2015

Salt is a necessity for humans and animals, today as in the ancient past. The ways in which salt was produced in ancient times vary from area to area, and could use briquetage, deep mining (as at Hallstatt), or the technique specific to Transylvania, based on wooden troughs, perforated in the base. How these troughs functioned is still uncertain. In the Iron Age a different technique was employed, involving deep shafts dug down to the rock salt surface. As well as technological considerations, it is crucial to understand the social and economic importance of salt in the ancient world.
Foodways architecture: storing, processing and dining structures at the Late Neolithic Vinča culture site at Stubline
Authors: Spasić Miloš , Živanović Saša 
Published: December 2015

The paper presents an analysis of storing, processing and dining structures from the Vinča culture site at Stubline. Numerous clay structures found in houses were associated with everyday activities related to food. We argue that these structures were not only important in subsistence strategies, but were also profound symbolic agents involved in complex symbolic practices related to the conceptualisation of social spaces in Vinča culture houses.
Identifying Neolithic animal management practices in the Adriatic using stable isotopes
Authors: Zavodny Emily , McClure Sarah B. , Culleton Brendan J. , Podrug Emil , Kennett Douglas J. 
Published: December 2015

We synthesise reported stable isotope values for domesticates and wild herbivores from sites spanning the Neolithic in coastal Croatia, Slovenia, and Italy (6000–3500 calBC). Carbon and nitrogen stable isotope values are analyzed as proxies of diet and environment, with differences between species possibly indicating anthropogenic influence. Results are used to characterise diets and address questions of the origin and development of husbandry strategies, especially transhumance, in early farming communities. Changes in pig carbon and nitrogen isotope values through time suggest alterations in practices, whereas values remain relatively constant for cattle and ovicaprids during most of the Neolithic, despite assumptions of seasonal mobility.
Some remarks on the cognitive impact of metallurgical development in promoting numerical and metrological abstraction in Europe
Authors: Dzbynski Aleksander 
Published: December 2015

If we accept the thesis that advanced metrological systems existed in Bronze Age societies, described and analysed as weight standards by many authors, we should also consider its simple consequence; these weight standards were the successors of earlier and rather simpler systems of value that developed within Eneolithic societies. Dealing with the issue of early metallurgy in Europe, some authors have traced patterns and proliferation cycles of copper for this period that allow us to see that the introduction of metal to the main regions in Europe was the subject of growth, spread, and changing social perspectives rather than a crisis in metal production and hiatus. This is the point, I think, at which we can embed one source of Bronze Age weight standards on the one hand, and earlier simpler methods of measuring copper, on the other.
The origin of farming in the Lower Volga Region
Authors: Vybornov Alexander , Kosintsev Pavel , Kulkova Marianna 
Published: December 2015

The paper focuses on the results of archaeological, palaezoological, and radiocarbon analyses of Neolithic and Eneolithic sites in the Northern Caspian and Lower Volga regions. New analyses show that only wild animal species inhabited the territory in the Neolithic. Animals were not domesticated until the Eneolithic period.
The origins of agriculture in Iberia: a computational model
Authors: Gordó Salvador Pardo , Bernabeu Aubán Joan , García Puchol Oreto , Barton Michael , Bergin Sean M. 
Published: December 2015

Here we discuss the importance of using the rich and growing database of high-precision, audited radiocarbon dates for high-resolution bottom-up modelling to focus on problems concerning the spread of the Neolithic in the Iberia. We also compare the spread of the Late Mesolithic (so-called Geometric) and the Early Neolithic using our modelling environment. Our results suggest that the source of radiocarbon data used to evaluate alternative hypotheses plays an important role in the results and open up new lines of research for the future.
LITER of de beginselen van goed markttoezicht
Authors: de Moor-van Vugt Adrienne 
Published: December 2015

LITER of de beginselen van goed markttoezicht
Ottow stelt in haar boek Market and Competition Authorities vast dat handhaving slechts het sluitstuk vormt van een omvattender strategie in het markttoezicht. Deze strategie moet worden ingebed in heldere uitgangspunten voor goed toezicht, LITER genoemd. Ottow ontleent inspiratie voor de ontwikkeling van LITER aan de ervaringen met de oprichting van ACM en de Britse CMA. De door inductief redeneren verkregen beginselen heeft zij vervolgens opnieuw tegen het licht gehouden van de theorie op dit gebied. Dit geheel biedt nuttige inzichten voor theorie en praktijk.
L’achat complice de contrefaçons de luxe en tant qu’expérience de consommation : quand la raison rencontre les sentiments
Authors: Maman Larraufie Anne-Flore 
Published: December 2015

La contrefaçon est une problématique clé pour le secteur du luxe, car elle impacte l’image des marques. Nous examinons la dimension non rationnelle de l’achat complice de contrefaçons de luxe, au travers de son aspect expérientiel, à partir de 24 entretiens en profondeur. Quatre dimensions sont identifiées : la sociabilité, le jeu, l’exotisme et le sensoriel. Les interactions entre celles-ci permettent de proposer des solutions de communication anti-contrefaçon pertinentes pour les acteurs du luxe et les pouvoirs publics.
La participation citoyenne comme pilier de changement social en bibliothèque publique
Authors: Désilets Marie 
Published: December 2015

Les concepts de « participation citoyenne » et d’« empowerment » circulent allègrement dans nos sociétés. Nous souhaitons d’abord nous arrêter sur la définition de ces concepts pour établir ensuite le lien étroit entre ceux-ci et le rôle de développement social des bibliothèques. Ainsi, les Bibliothèques publiques de Montréal, ville de savoir, adhèrent aux valeurs inhérentes à la participation citoyenne : ouverture, égalité, inclusion, innovation, etc. Elles contribuent par leurs actions à favoriser l’autonomie du citoyen et sa participation active à la vie en société. Des exemples mettant en présence différentes clientèles seront apportés et les conditions favorables à la participation citoyenne seront ciblées. Enfin, nous tenterons d’évaluer les impacts de telles actions dans une perspective de développement durable : comment les bibliothèques publiques peuvent-elles se positionner et contribuer à l’Agenda 21 de la culture dans une perspective de développement durable ? Quelle est la pertinence d’investir et d’encourager la participation citoyenne dans nos bibliothèques ? Quelles retombées anticiper à long terme ? La description de quelques expériences, en développement social et urbain notamment, nous permettront d’y réfléchir.
Entrer en littérature : premiers romans et primo-romanciers au Québec, 1998-2008
Authors: Abensour Corinne , Legendre Bertrand , Luneau Marie-Pier 
Published: December 2015

La question de la publication d’un premier roman appelle souvent, dans le champ littéraire, la circulation de scénarios mythiques fréquemment opposés, à savoir celui de l’écrivain inconnu qui accède subitement à la gloire, et celui de l’auteur incompris de son vivant, que seule la postérité reconnaîtra enfin. En réalité, qui sont les auteurs de premiers romans au Québec, dans les dernières années ? À quel âge accèdent-ils à la publication ? Après combien de tentatives ? Comment perçoivent-ils leur travail avec leur éditeur ? Cet article expose en détails les résultats inédits d’une enquête menée en 2010 auprès de 79 auteurs québécois, en parallèle avec une vaste enquête lancée en même temps en France.
Nommage de documents électroniques : mise au point et évaluation d’une procédure
Authors: Morlanne-Fendan Pierre , Tanti Marc 
Published: December 2015

Le nommage des documents lors de leur enregistrement est une question problématique. En effet, quel nom attribuer pour retrouver plus facilement l’information ? Il n’existe malheureusement pas de procédure standardisée (ISO ou AFNOR) pour ce faire. Cet article a pour objet de proposer un ensemble de neuf règles constituant une procédure qui pourra servir de base à une norme. Sur un corpus traitant du risque sanitaire, elle a été appliquée et son résultat évalué. Cent pour cent des répondants de l’étude ont estimé qu’elle permettait de retrouver plus facilement et rapidement l’information et apportait des données sur le contenu sans qu’il soit nécessaire d’ouvrir le document.
Les bibliothèques universitaires québécoises et la génération C
Authors: Laplante Audrey 
Published: December 2015

La majorité des étudiants qui entrent à l’université aujourd’hui appartiennent à la génération C. Cette génération est orientée vers le travail en équipe, apprécie les modes d’apprentissage actifs et collaboratifs et est à l’aise avec les technologies. Comment les bibliothèques québécoises se sont-elles adaptées à cette clientèle et à l’importance accrue des ressources numériques ? Cet article décrit les changements qui se sont opérés dans les bibliothèques nord-américaines et présente les résultats d’une enquête réalisée auprès des bibliothèques universitaires québécoises sur l’aménagement de leurs espaces et sur les technologies, les services de soutien et les séances de formation qu’elles proposent.
Formação dos agentes comunitários de saúde no município de Altamira (PA), Brasil
Authors: Freitas Lagerson Mauad , Coriolano‑Marinus Maria Wanderleya De Lavor , Lima Luciane Soares de , Ruiz‑Moreno Lídia 
Published: December 2015

Introdução: A expansão da Estratégia Saúde da Família (ESF) coloca em destaque o Agente Comunitário de Saúde (ACS) na condição de importante ator social na viabilização do Sistema Único de Saúde (SUS). Objetivo: Caracterizar o perfil socioeconômico e demográfico, processo de formação e o papel educativo junto à comunidade do ACS no município de Altamira (PA). Métodos: O estudo, de caráter descritivo‑exploratório, utilizou para a coleta de dados questionário semiestruturado aplicado a 63 ACS. Os dados foram tabulados no Programa Excel e expressos em frequências absoluta e relativa. A análise temática foi utilizada para as questões relacionadas à formação do ACS. Resultados: O perfil socioeconômico dos agentes evidencia aspectos similares aos da comunidade atendida. A maioria dos participantes considera que recebeu formação para atender as atribuições legais. As demandas de formação dos ACS referem‑se a conhecimentos específicos sobre álcool e drogas e vigilância em saúde, procedimentos técnicos de saúde, comunicação, relacionamento interpessoal, ética e identidade profissional. As ações educativas desenvolvidas pelos ACS na comunidade compreendem palestras e visitas domiciliares. Conclusão: Observa‑se a importância da normatização do processo de formação do ACS de forma a oferecer subsídios para o desenvolvimento de ações educativas dialógicas e contribuir com a construção da identidade desse profissional que ocupa espaço estratégico nas políticas brasileiras de atenção básica.
Tecnologias e o ensino na área da Saúde
Authors: Pessoni Arquimedes , Goulart Elias 
Published: December 2015

O artigo de revisão versa sobre a mudança de configuração dada em sala de aula e fora dela a partir da adoção de redes sociais digitais como possibilidade de relacionamento entre alunos e professores. Os trabalhos consultados revelam uma tendência à adoção de novas formas de ensino e aprendizagem a partir da inclusão de tecnologia mediando os públicos envolvidos. Ressaltando trabalhos de sucesso e outros não muito felizes em que novas ferramentas foram adotadas por professores, as considerações apontam para a necessidade de adaptação por parte dos docentes para uma nova realidade de mercado em que o cliente, entendido aqui como aluno, traz consigo uma nova forma de aprender, inserindo a tecnologia como ferramenta necessária para que o conteúdo seja assimilado mais facilmente.
Diretrizes Curriculares na saúde e as mudanças nos modelos de saúde e de educação
Authors: Moreira Carlos Otávio Fiúza , Dias Maria Socorro De Araújo 
Published: December 2015

Artigo produzido a partir de pesquisa bibliográfica e de questões formuladas para uma conferência no módulo “Educação na Saúde II” do Mestrado Profissional da Rede Nordeste de Formação em Saúde da Família. O texto discute questões dos campos da saúde e da educação relacionadas à emergência de novos modelos de saúde e de formação; analisa também as Diretrizes Curriculares Nacionais (DCN) de três cursos da área da saúde (Medicina, Enfermagem e Odontologia) como expressão desses novos modelos para saúde e para a educação. Uma questão transversal ao artigo são as relações entre os campos da saúde e da educação. Para isto, lança‑se mão do conceito de campo, desenvolvido pelo sociólogo Pierre Bourdieu. Considera‑se, ainda, o desafio de transformar as DCN em currículos e programas, ferramentas ou dispositivos necessários para fazer a passagem do que está prescrito para os cenários de ensino e aprendizagem.
Residência multiprofissional tecendo práticas interdisciplinares na prevenção da violência
Authors: Bones Ana Amélia Nascimento da Silva , Cazella Silvio César , Weber Lara Susane , Costa Maira Rafaela Röhrig da , Saraiva Márcia Pereira , Bopsin Marina Ramos 
Published: December 2015

Introdução: A complexidade da atenção às situações de violência requer o investimento na integralidade das ações e do cuidado, lançando às equipes multiprofissionais o desafio da construção de uma prática interdisciplinar em conjunto com a escola. Relato de experiência: Analisar a integralidade da atenção à saúde e à educação a partir da ação das residentes do Programa da Residência Integrada Multiprofissional em Saúde da Criança comtransversalidade em violências e vulnerabilidades inseridas numa equipe de Estratégia de Saúde da Família no Município de Porto Alegre e na escola estadual pertencente ao seu território. Trata‑se da experiência interdisciplinar desenvolvida em dois níveis de abordagem: com os alunos do 1° ao 4° ano através de atividades lúdicas; e com os pais e responsáveis através da roda de conversa. A base da intervenção foram as oficinas com os alunos, buscando problematizar, através de intervenções lúdicas e brincadeiras, assituações de violência percebidas nos seus diversos ambientes. Conclusão: A prática interdisciplinar de forma consciente permite a organização do processo de trabalho com o escopo da prática colaborativa em projeto de educação interprofissional.
Quantitative analysis of the interplay between hsc70 and its co-chaperone HspBP1
Authors: Mahboubi Hicham , Stochaj Ursula 
Published: December 2015

Background.Chaperones and their co-factors are components of a cellular network; they collaborate to maintain proteostasis under normal and harmful conditions. In particular, hsp70 family members and their co-chaperones are essential to repair damaged proteins. Co-chaperones are present in different subcellular compartments, where they modulate chaperone activities.Methods and Results.Our studies assessed the relationship between hsc70 and its co-factor HspBP1 in human cancer cells. HspBP1 promotes nucleotide exchange on hsc70, but has also chaperone-independent functions. We characterized the interplay between hsc70 and HspBP1 by quantitative confocal microscopy combined with automated image analyses and statistical evaluation. Stress and the recovery from insult changed significantly the subcellular distribution of hsc70, but had little effect on HspBP1. Single-cell measurements and regression analysis revealed that the links between the chaperone and its co-factor relied on (i) the physiological state of the cell and (ii) the subcellular compartment. As such, we identified a linear relationship and strong correlation between hsc70 and HspBP1 distribution in control and heat-shocked cells; this correlation changed in a compartment-specific fashion during the recovery from stress. Furthermore, we uncovered significant stress-induced changes in the colocalization between hsc70 and HspBP1 in the nucleus and cytoplasm.Discussion.Our quantitative approach defined novel properties of the co-chaperone HspBP1 as they relate to its interplay with hsc70. We propose that changes in cell physiology promote chaperone redistribution and thereby stimulate chaperone-independent functions of HspBP1.