bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensual Assessment of Creativity in Teaching Design by Supportive Peers—Its Validity, Practicality, and Benefit
Authors: Cheng Vivian M. Y. 
Published: November 2015

AbstractCreativity in teaching is a significant and complex construct. However, in the local educational context, creativity in teaching has received little attention. This study aimed to investigate the validity, practicality, and benefits of applying a modified consensual assessment technique (CAT) to assess creativity in teaching design. Four hundred and eighty‐five written teaching designs were collected from 167 in‐service and pre‐service primary school teachers in Hong Kong. Instead of expert teachers, “supportive” peers, who had shown support, interest, and initiative in creative teaching were recruited as judges. A warm‐up exercise, with no definition of creativity, was given to the judges before beginning their assessments. The results indicated overall consistency in the judges' assessments of creativity, and that creativity factor could be distinguished from pedagogical skills and other technical factors. Most of the peer judges reported personal gains in creative teaching by engaging in the assessment process. On average, each judge spent approximately only 2 minutes rating each written teaching design. The findings confirm that the modified CAT is a valid and economical assessment method with learning benefits for the judges. The special values and implications of using supportive peer judges in consensual assessment are further discussed.
Do People Really Have Insights in the Shower? The When, Where and Who of the Aha! Moment
Authors: Ovington Linda A. , Saliba Anthony J. , Moran Carmen C. , Goldring Jeremy , MacDonald Jasmine B. 
Published: November 2015

AbstractWhile there are well‐known anecdotes and documented insight cases by renowned scientists and inventors, little is known about the experiences of insight in the general population. The present study aimed to determine peoples' self‐reported experience of insight in their daily lives. Using an online questionnaire, responses were obtained from 1,114 respondents. Eighty‐percent reported having insights. These respondents reported demographic information and answered three open‐ended questions on where their insights occur, what insights are and other thoughts on insight. A greater percentage of those who have insights are, female, younger, highly educated, and involved in occupations including, management, sciences, arts and service professions. The qualitative results uncovered eight major themes, reflecting on the places people have insights: At night, work, shower, home, when it is quiet, transport, while exercising, and in nature. Two major themes emerged on what insights are: Something from the subconscious, and a result of (not) thinking. Finally, three major themes emerged from the third question on thoughts they would like to share on insight: The improvement of insight with age, the importance of analyzing the details of the problem, and the unexpectedness of the solution. Results are discussed in the context of the current experimental research on insight.
Creativity Is Life: A Commentary on the Special Issue
Authors: Kaufman James C. 
Published: November 2015

AbstractIn this commentary on the papers in the special issue, I discuss how many of the standard questions and debates in the field of creativity research tend to focus on the individual creator. The welcome recent resurgence of interest in questions of context, interaction, culture, and audience—as on full display in this special issue—is cause to reflect not merely on these specific points but on how the deeper philosophy can resonate in how we study creativity and approach life itself.
Detection of related substances in polyene phosphatidyl choline extracted from soybean and in its commercial capsule by comprehensive supercritical fluid chromatography with mass spectrometry compared with HPLC with evaporative light scattering detection
Authors: Jiang Qikun , Liu Wanjun , Li Xiaoting , Zhang Tianhong , Wang Yongjun , Liu Xiaohong 
Published: November 2015

Supercritical fluid chromatography with tandem mass spectrometry was used to comprehensively profile polyene phosphatidyl choline (PPC) extracted from soybean. We achieved an efficient chromatographic analysis using a BEH‐2EP column (3 × 100 mm2, 1.7 μm) with a mobile phase consisting of CO2 and a cosolvent in gradient combination at a flow rate of 1.0 mL/min. The cosolvent consisted of methanol, acetonitrile, and water (containing 10 mM ammonium acetate and 0.2% formic acid). The total single‐run time was 7 min. We used this method to accurately detect ten different phospholipids (PLs) during extraction. The limits of quantification for phosphatidyl choline, lyso‐phosphatidylcholine (LPC), phosphatidic acid (PA), sphingomyelin, phosphatidyl glycerol, phosphatidyl inositol (PI), cholesterol, cardiolipin, phosphatidyl serine, and phosphatidyl ethanolamine (PE) were 20.6, 19.52, 1.21, 2.38, 0.50, 2.28, 54.3, 0.60, 0.65, and 4.85 ng/mL, respectively. However, adopting the high‐performance liquid chromatography with evaporative light scattering detection method issued by the China Food and Drug Administration, only PA, LPC, PE, PI, and PPC could be analyzed accurately, and the limits of quantification were 33.89, 60.5, 30.3, 10.9, and 61.79 μg/mL, respectively. The total single‐run time was at the least 20 min. Consequently, the supercritical fluid chromatography with tandem mass spectrometry method was more suitable for the analysis of related PLs.
Zinc supplementation induces regulatory T cells by inhibition of Sirt‐1 deacetylase in mixed lymphocyte cultures
Authors: Rosenkranz Eva , Metz Claudia H.D. , Maywald Martina , Hilgers Ralf‐Dieter , Weßels Inga , Senff Tina , Haase Hajo , Jäger Maximilian , Ott Melanie , Aspinall Richard , Plümäkers Birgit , Rink Lothar 
Published: November 2015

ScopeZinc is an essential trace element, regulating immune function. Its deficiency results in immune dysfunction and transplant rejection. In here, a benefit of zinc supplementation for the induction of tolerance was investigated, focusing on the TH1‐dominated allogeneic immune reaction.Methods and resultsAllogeneic immune reaction was modeled by mixed lymphocyte culture (MLC). The effect of zinc supplementation was monitored via expression of cytokines and surface lineage markers using ELISA and flow cytometry. Epigenetic analyses were performed to investigate mechanisms underlying zinc‐induced changes in regulatory T cell (Treg) activation. Results reveal that Tregs are induced when MLCs are treated with 50 μM zinc causing a decrease in IFNγ production. IL‐2 and IL‐10 expression were not affected. The teleology of this effect includes the inhibition of histone deacetylase Sirt‐1‐mediated Foxp3 deacetylation, resulting in its decreased degradation.ConclusionIn conclusion, zinc should be considered to prevent graft‐versus‐host disease (GVHD) as it is capable of stabilizing iTregs, resulting in increased numbers of this cell type while not suppressing the immune system.
2D Pulses using spatially dependent frequency sweeping
Authors: Jang Albert , Kobayashi Naoharu , Moeller Steen , Vaughan J. Thomas , Zhang Jianyi , Garwood Michael 
Published: November 2015

PurposeTo introduce a method of designing two‐dimensional (2D) frequency‐modulated pulses that produce phase coherence in a spatiotemporal manner. Uniquely, this class of pulses provides the ability to compensate for field inhomogeneity using a spatiotemporally dependent trajectory of maximum coherence in a single‐shot.Theory and MethodsA pulse design method based on a k‐space description is developed. Bloch simulations and phantom experiments are used to demonstrate sequential spatiotemporal phase coherence and compensation for
and B0 inhomogeneity.ResultsIn the presence of modulated gradients, the 2D frequency‐modulated pulses were shown to excite a cylinder in a selective manner. With a surface coil transmitter, compensation of the effect of
inhomogeneity was experimentally verified, in agreement with simulation results. In addition, simulations were used to demonstrate partial compensation for B0 inhomogeneity.ConclusionThe 2D frequency‐modulated pulses are a new class of pulses that generate phase coherence sequentially along a spatial trajectory determined by gradient‐ and frequency‐modulated functions. By exploiting their spatiotemporal nature, 2D frequency‐modulated pulses can compensate for spatial variation of the radiofrequency field in a single‐shot excitation. Preliminary results shown suggest extensions might also be used to compensate for static field inhomogeneity. Magn Reson Med 76:1364–1374, 2016. © 2015 International Society for Magnetic Resonance in Medicine
Highly redox‐stable and electrochromic aramids with morpholinyl‐substituted triphenylamine units
Authors: Hsiao Sheng‐Huei , Hsiao Ying‐Hsiu , Kung Yu‐Ruei 
Published: November 2015

ABSTRACTA novel morpholinyl‐substituted, triphenylamine‐based diamine monomer, namely 4,4′‐diamino‐4″‐(4‐morpholinyl)triphenylamine, was synthesized and polymerized with various aromatic dicarboxylic acids via the phosphorylation polyamidation reaction leading to a series of electroactive aromatic polyamides (aramids). All aramids were readily soluble in polar organic solvents and could be solution cast into tough and flexible films with high thermal stability. Cyclic voltammograms of the aramid films on the indium‐tin oxide‐coated glass substrate exhibited a pair of reversible oxidation waves with very low onset potentials of 0.36 − 0.41 V (vs. Ag/AgCl) in acetonitrile solution. The polymer films showed reversible electrochemical oxidation accompanied by strong color changes with high coloration efficiency, high contrast ratio, and rapid switching time. The optical transmittance change (Δ%T) at 650 nm between the neutral state and the fully oxidized state is up to 90%. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 1289–1298
Correspondence in Stakeholder Assessment of Health, Work Capacity and Sick Leave in Workers with Comorbid Subjective Health Complaints? A Video Vignette Study
Authors: Maeland Silje , Magnussen Liv Heide , Eriksen Hege R. , Werner Erik L. , Helle-Valle Anna , Hensing Gunnel 
Published: November 2015

Abstract

Purpose The purpose of this study is to test if there is correspondence in stakeholders’ assessments of health, work capacity and sickness certification in four workers with comorbid subjective health complaints based on video vignettes. Methods A cross sectional survey among stakeholders (N = 514) in Norway in 2009/2010. Logistic regression and multinomial logistic regression was used to obtain the estimated probability of stakeholders choosing 100 % sick leave, partial sick leave or work and the estimation of odds ratio of stakeholder assessment compared to the other stakeholders for the individual worker. Results The supervisors were less likely to assess poor health and reduced work capacity, and more likely to suggest partial sick leave and full time work compared to the GPs for worker 1. The public was less likely to assess comorbidity and reduced work capacity, and 6 and 12 times more likely to suggest partial sick leave and full time work compared to the GPs for worker 1. Stakeholders generally agreed in their assessments of workers 2 and 3. The public was more likely to assess poor health, comorbidity and reduced work capacity, and the supervisors more likely to assess comorbidity and reduced work capacity, compared to the GPs for worker 4. Compared to the GPs, all other stakeholders were less likely to suggest full time work for this worker. Conclusions Our results seem to suggest that stakeholders have divergent assessments of complaints, health, work capacity, and sickness certification in workers with comorbid subjective health complaints.
Solvent and Extraction Conditions Control the Assayable Phenolic Content and Antioxidant Activities of Seeds of Black Beans, Canola and Millet
Authors: Chandrasekara Anoma , Rasek Omar Abdel , John Jenny Ann , Chandrasekara Neel , Shahidi Fereidoon 
Published: November 2015

AbstractThe effects of extraction solvent and conditions on the total phenolic content (TPC) and antioxidant activity of black beans, canola and foxtail millet were investigated. The antioxidant activity was assayed using 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activity (DRSA) and oxygen radical absorbance capacity (ORAC). Four solvent systems, namely 70 % acetone, 80 % ethanol, 80 % methanol and a mixture of acetone/methanol/water (7:7:6, v/v/v) were used. The extraction methods adopted in this study included refluxing, homogenization, cold extraction and sonication. The TPC as measured using the Folin Ciocalteu's method were 12.35–28.39, 2.43–16.73, and 1.78–5.06 µmol catechin equivalents/g dry matter (dm) for canola, black beans and foxtail millet, respectively. Aqueous acetone afforded the highest TPC for black beans and canola. Within the same solvent system used, the TPC, DRSA and ORAC obtained from different extraction techniques differed for black beans, canola and foxtail millet. The results demonstrated that the solvent system as well as method influenced the extraction of phenolic compounds and their antioxidant activities, depending on the type of matrix in which phenolics were embedded.
Validation of the Everyday Technology Use Questionnaire in a Japanese Context
Authors: Malinowsky Camilla , Kottorp Anders , Tanemura Rumi , Asaba Eric , Nagao Toru , Noda Kazue , Sagara Jiro , Bontje Peter , Rosenberg Lena , Nygård Louise 
Published: November 2015

Background/Objective The Everyday Technology Use Questionnaire (ETUQ), which evaluates the perceived relevance of and the perceived ability in everyday technology (ET) use, has demonstrated acceptable psychometric properties in Swedish studies of older adults. The aim of this study was to examine the reliability and validity of the ETUQ in a Japanese context in older Japanese adults. Methods A sample of older Japanese adults (n = 164) including persons with (n = 32) and without (n = 132) cognitive impairment was interviewed with the ETUQ, including original items (ETs) and added Japanese context-specific items. Data were analyzed using a Rasch measurement model. Results The analysis demonstrated acceptable functioning of the rating scale, internal scale validity, person response validity, and person-separation reliability of the Japanese ETUQ according to the Rasch model. However, evidence supporting unidimensionality in the Japanese ETUQ was not consistent in this sample. The added Japanese items did not significantly change the estimated individual person measures of perceived ability to use ET. Conclusion The Japanese ETUQ seems to be a sensitive tool to evaluate perceived ability in ET use among elderly people in Japan with and without cognitive impairment. Therefore, it could be used in research and clinical practice.
Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia‐ischemia
Authors: Chavez‐Valdez Raul , Flock Debbie L. , Martin Lee J. , Northington Frances J. 
Published: November 2015

AbstractThe endoplasmic reticulum (ER) is tasked, among many other functions, with preventing excitotoxicity from killing neurons following neonatal hypoxia‐ischemia (HI). With the search for delayed therapies to treat neonatal HI, the study of delayed ER responses becomes relevant. We hypothesized that ER stress is a prominent feature of delayed neuronal death via programmed necrosis after neonatal HI. Since necrostatin‐1 (Nec‐1), an inhibitor of programmed necrosis, provides delayed neuroprotection against neonatal HI in male mice, Nec‐1 is an ideal tool to study delayed ER responses. C57B6 male mice were exposed to right carotid ligation followed by exposure to FiO2 = 0.08 for 45 min at p7. Mice were treated with vehicle or Nec‐1 (0.1 μl of 8 μmol) intracerebroventricularly with age‐matched littermates as controls. Biochemistry assays at 3 and 24 h and electron microscopy (EM) and immunohistochemistry at 96 h after HI were performed. EM showed ER dilation and mitochondrial swelling as apparent early changes in neurons. With advanced neurodegeneration, large cytoplasmic fragments containing dilated ER “shed” into the surrounding neuropil and calreticulin immunoreactivity was lost concurrent with nuclear features suggestive of programmed necrosis. Nec‐1 attenuated biochemical markers of ER stress after neonatal HI, including PERK and eIF2α phosphorylation, and unconventional XBP‐1 splicing, consistent with the mitigation of later ER pathology. ER pathology may be an indicator of severity of neuronal injury and potential for recovery characterized by cytoplasmic shedding, distinct from apoptotic blebbing, that we term neuronal macrozeiosis. Therapies to attenuate ER stress applied at delayed stages may rescue stressed neurons after neonatal HI.
Improvement and retention of emergency obstetrics and neonatal care knowledge and skills in a hospital mentorship program in Lilongwe, Malawi
Authors: Tang Jennifer H. , Kaliti Charlotte , Bengtson Angela , Hayat Sumera , Chimala Eveles , MacLeod Rachel , Kaliti Stephen , Sisya Fanny , Mwale Mwawi , Wilkinson Jeffrey 
Published: November 2015

AbstractObjectiveTo evaluate whether a hospital‐based mentoring program could significantly increase short‐ and longer‐term emergency obstetrics and neonatal care (EmONC) knowledge and skills among health providers.MethodsIn a prospective before‐and‐after study, 20 mentors were trained using a specially‐created EmONC mentoring and training program at Bwaila Hospital in Lilongwe, Malawi. The mentors then trained an additional 114 providers as mentees in the curriculum. Mentors and mentees were asked to complete a test before initiation of the training (Pre‐Test), immediately after training (Post‐Test 1), and at least 6 months after training (Post‐Test 2) to assess written and practical EmONC knowledge and skills. Mean scores were then compared.ResultsScores increased significantly between the Pre‐Test and Post‐Test 1 for both written (n = 134; difference 22.9%, P < 0.001) and practical (n = 125; difference 29.5%, P < 0.001) tests. Scores were still significantly higher in Post‐Test 2 than in the Pre‐Test for written (n = 111; difference 21.0%, P < 0.001) and practical (n = 103; difference 29.3%, P < 0.001) tests.ConclusionA hospital‐based mentoring program can result in both short‐ and longer‐term improvement in EmONC knowledge and skills. Further research is required to assess whether this leads to behavioral changes that improve maternal and neonatal outcomes.
Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits
Authors: Wortham Noel C. , Stewart Joanna D. , Harris Sean , Coldwell Mark J. , Proud Christopher G. 
Published: November 2015

The eukaryotic translation initiation factor eIF2B is a multi-subunit complex with a crucial role in the regulation of global protein synthesis in the cell. The complex comprises five subunits, termed α through ε in order of increasing size, arranged as a heterodecamer with two copies of each subunit. Regulation of the co-stoichiometric expression of the eIF2B subunits is crucial for the proper function and regulation of the eIF2B complex in cells. We have investigated the control of stoichiometric eIF2B complexes through mutual stabilization of eIF2B subunits.
Our data show that the stable expression of the catalytic eIF2Bε subunit in human cells requires co-expression of eIF2Bγ. Similarly, stable expression of eIF2Bδ requires both eIF2Bβ and eIF2Bγ+ε. The expression of these subunits decreases despite there being no change in either the levels or the translation of their mRNAs. Instead, these subunits are targeted for degradation by the ubiquitin–proteasome system.
The data allow us to propose a model for the formation of stoichiometric eIF2B complexes which can ensure their stoichiometric incorporation into the holocomplex.
The cancer-promoting gene fatty acid-binding protein 5 (FABP5) is epigenetically regulated during human prostate carcinogenesis
Authors: Kawaguchi Koichiro , Kinameri Ayumi , Suzuki Shunsuke , Senga Shogo , Ke Youqiang , Fujii Hiroshi 
Published: November 2015

FABPs (fatty-acid-binding proteins) are a family of low-molecular-mass intracellular lipid-binding proteins consisting of ten isoforms. FABPs are involved in binding and storing hydrophobic ligands such as long-chain fatty acids, as well as transporting these ligands to the appropriate compartments in the cell. FABP5 is overexpressed in multiple types of tumours. Furthermore, up-regulation of FABP5 is strongly associated with poor survival in triple-negative breast cancer. However, the mechanisms underlying the specific up-regulation of the FABP5 gene in these cancers remain poorly characterized. In the present study, we determined that FABP5 has a typical CpG island around its promoter region. The DNA methylation status of the CpG island in the FABP5 promoter of benign prostate cells (PNT2), prostate cancer cells (PC-3, DU-145, 22Rv1 and LNCaP) and human normal or tumour tissue was assessed by bisulfite sequencing analysis, and then confirmed by COBRA (combined bisulfite restriction analysis) and qAMP (quantitative analysis of DNA methylation using real-time PCR). These results demonstrated that overexpression of FABP5 in prostate cancer cells can be attributed to hypomethylation of the CpG island in its promoter region, along with up-regulation of the direct trans-acting factors Sp1 (specificity protein 1) and c-Myc. Together, these mechanisms result in the transcriptional activation of FABP5 expression during human prostate carcinogenesis. Importantly, silencing of Sp1, c-Myc or FABP5 expression led to a significant decrease in cell proliferation, indicating that up-regulation of FABP5 expression by Sp1 and c-Myc is critical for the proliferation of prostate cancer cells.
Identification of drug–target interaction from interactome network with ‘guilt-by-association’ principle and topology features
Authors: Li Zhan-Chao , Huang Meng-Hua , Zhong Wen-Qian , Liu Zhi-Qing , Xie Yun , Dai Zong , Zou Xiao-Yong 
Published: November 2015

Abstract
Motivation: Identifying drug–target protein interaction is a crucial step in the process of drug research and development. Wet-lab experiment are laborious, time-consuming and expensive. Hence, there is a strong demand for the development of a novel theoretical method to identify potential interaction between drug and target protein.
Results: We use all known proteins and drugs to construct a nodes- and edges-weighted biological relevant interactome network. On the basis of the ‘guilt-by-association’ principle, novel network topology features are proposed to characterize interaction pairs and random forest algorithm is employed to identify potential drug–protein interaction. Accuracy of 92.53% derived from the 10-fold cross-validation is about 10% higher than that of the existing method. We identify 2272 potential drug–target interactions, some of which are associated with diseases, such as Torg-Winchester syndrome and rhabdomyosarcoma. The proposed method can not only accurately predict the interaction between drug molecule and target protein, but also help disease treatment and drug discovery.
Contacts: zhanchao8052@gmail.com or ceszxy@mail.sysu.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.