bluuebunny/crossref_metadata_2025_split huggingface dataset:
An optical and electrical study of full thermally activated delayed fluorescent white organic light-emitting diodes
Authors: Pereira Daniel de Sa , dos Santos Paloma L. , Ward Jonathan S. , Data Przemyslaw , Okazaki Masato , Takeda Youhei , Minakata Satoshi , Bryce Martin R. , Monkman Andrew P. 
Published: July 2017

AbstractWe report on the engineering of full thermally activated delayed fluorescence – based white organic light emitting diodes (W-OLEDs) composed of three emitters (2,7-bis(9,9-dimethyl-acridin-10-yl)-9,9-dimethylthioxanthene-S,S-dioxide (DDMA-TXO2), 2,7-bis(phenoxazin-10-yl)-9,9-dimethylthioxanthene-S,S-dioxide (DPO-TXO2) and 3,11-di(10H-phenoxazin-10-yl)dibenzo[a,j]phenazine (POZ-DBPHZ) in two different hosts. By controlling the device design through the study of the emission of DDMA-TXO2 and DPO-TXO2, the behaviour of POZ-DBPHZ in a device with more than one emitter, and the combination of the three materials, respectively, we show that external quantum efficiencies as high as 16% can be obtained for a structure with a correlated colour temperature close to warm white, together with colour rendering index close to 80. However it is in their performance stability that provides the true breakthrough: at 1000 cd/m2 the efficiencies were still above 10%, which is one of the best for this type of devices.
Aspergillus labruscus sp. nov., a new species of Aspergillus section Nigri discovered in Brazil
Authors: Fungaro Maria Helena P. , Ferranti Larissa S. , Massi Fernanda P. , da Silva Josué J. , Sartori Daniele , Taniwaki Marta H. , Frisvad Jens C. , Iamanaka Beatriz T. 
Published: July 2017

AbstractA novel fungal species, Aspergillus labruscus sp. nov., has been found in Brazil during an investigation of the fungal species present on the surface of grape berries (Vitis labrusca L.) for use in the production of concentrated grape juice. It seems to be associated to V. labrusca, and has never been recovered from Vitis vinifera. This new species belonging to Aspergillus subgenus Circumdati section Nigri is described here using morphological characters, extrolite profiling, partial sequence data from the BenA and CaM genes, and internal transcribed spacer sequences of ribosomal DNA. Phenotypic and molecular data enabled this novel species to be clearly distinguished from other black aspergilli. A. labruscus sp. nov. is uniseriate, has yellow mycelium, poor sporulation on CYA at 25 °C, abundant salmon to pink sclerotia and rough conidia. Neoxaline and secalonic acid D were consistently produced by isolates in this taxon. The type strain of A. labruscus sp. nov. is CCT 7800 (T) = ITAL 22.223 (T) = IBT 33586 (T).
Host seeking parasitic nematodes use specific odors to assess host resources
Authors: Baiocchi Tiffany , Lee Grant , Choe Dong-Hwan , Dillman Adler R. 
Published: July 2017

AbstractEntomopathogenic nematodes (EPNs) are insect parasites used as biological control agents. Free-living infective juveniles (IJs) of EPNs employ host-seeking behaviors to locate suitable hosts for infection. We found that EPNs can differentiate between naïve and infected hosts, and that host attractiveness changes over time in a species-specific manner. We used solid-phase microextraction and gas chromatography/mass spectrometry to identify volatile chemical cues that may relay information about a potential host’s infection status and resource availability. Among the chemicals identified from the headspace of infected hosts, 3-Methyl-2-buten-1-ol (prenol) and 3-Hydroxy-2-butanone (AMC) were selected for further behavioral assays due to their temporal correlation with the behavioral changes of IJs towards the infected hosts. Both compounds were repulsive to IJs of Steinernema glaseri and S. riobrave in a dose-dependent manner when applied on an agar substrate. Furthermore, the repulsive effects of prenol were maintained when co-presented with the uninfected host odors, overriding attraction to uninfected hosts. Prenol was attractive to dauers of some free-living nematodes and insect larvae. These data suggest that host-associated chemical cues may have several implications in EPN biology, not only as signals for avoidance and dispersal of conspecifics, but also as attractants for new potential hosts.
A receptor dependent-4D QSAR approach to predict the activity of mutated enzymes
Authors: Kumar R. Pravin , Kulkarni Naveen 
Published: July 2017

AbstractScreening and selection tools to obtain focused libraries play a key role in successfully engineering enzymes of desired qualities. The quality of screening depends on efficient assays; however, a focused library generated with a priori information plays a major role in effectively identifying the right enzyme. As a proof of concept, for the first time, receptor dependent – 4D Quantitative Structure Activity Relationship (RD-4D-QSAR) has been implemented to predict kinetic properties of an enzyme. The novelty of this study is that the mutated enzymes also form a part of the training data set. The mutations were modeled in a serine protease and molecular dynamics simulations were conducted to derive enzyme-substrate (E-S) conformations. The E-S conformations were enclosed in a high resolution grid consisting of 156,250 grid points that stores interaction energies to generate QSAR models to predict the enzyme activity. The QSAR predictions showed similar results as reported in the kinetic studies with >80% specificity and >50% sensitivity revealing that the top ranked models unambiguously differentiated enzymes with high and low activity. The interaction energy descriptors of the best QSAR model were used to identify residues responsible for enzymatic activity and substrate specificity.
A self-supporting bimetallic Au@Pt core-shell nanoparticle electrocatalyst for the synergistic enhancement of methanol oxidation
Authors: Tan Changhui , Sun Yinghui , Zheng Jianzhong , Wang Dan , Li Ziyang , Zeng Huajie , Guo Jun , Jing Liqiang , Jiang Lin 
Published: July 2017

AbstractThe morphology of Pt−Au bimetal nanostructures plays an important role in enhancing the catalytic capability, catalytic stability and utilization efficiency of the platinum. We designed and successfully prepared Au@Pt nanoparticles (NPs) through an economical, surfactant-free and efficient method of seed-mediated growth. The Au@Pt NPs displayed electrochemical performances superior to those of commercial Pt/C catalysts because their agglomeration was prevented and exhibited better long-term stability with respect to methanol oxidation in acidic media by efficiently removing intermediates. Among the obtained Au@Pt NPs, Au90@Pt10NPs exhibited the most significantly enhanced catalytic performance for the methanol oxidation reaction (MOR). Their mass and electrochemically active surface area (ECSA)-normalized current densities are approximately 3.9 and 4.6 times higher than those of commercial Pt/C catalysts, respectively. The oxidation current densities of the Au90@Pt10NPs are approximately 1.8 times higher than those of commercial Pt/C catalysts after 4000 s of continuous measurement because the small Pt NPs grown on the surface of the Au90@Pt10NPs were effectively stabilized by the Au metal support. This approach may be a facile method for the synthesis of self-supported bimetallic nanostructures, which is of great significance for the development of high performance electrocatalysts and sensors.
Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
Authors: Vesterbacka Jan , Rivera Javier , Noyan Kajsa , Parera Mariona , Neogi Ujjwal , Calle Malu , Paredes Roger , Sönnerborg Anders , Noguera-Julian Marc , Nowak Piotr 
Published: July 2017

AbstractGut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal microbiota were significantly higher in EC versus naive. Genera Succinivibrio, Sutterella, Rhizobium, Delftia, Anaerofilum and Oscillospira were more abundant in EC, whereas Blautia and Anaerostipes were depleted. Additionally, carbohydrate metabolism and secondary bile acid synthesis pathway related genes were less represented in EC. Conversely, fatty acid metabolism, PPAR-signalling and lipid biosynthesis proteins pathways were enriched in EC vs naive. The kynurenine pathway of tryptophan metabolism was altered during progressive HIV infection, and inversely associated with microbiota richness. In conclusion, EC have richer gut microbiota than untreated HIV patients, with unique bacterial signatures and a distinct metabolic profile which may contribute to control of HIV.
Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape
Authors: Stortz Martin , Presman Diego M. , Bruno Luciana , Annibale Paolo , Dansey Maria V. , Burton Gerardo , Gratton Enrico , Pecci Adali , Levi Valeria 
Published: July 2017

AbstractThe distribution of the transcription machinery among different sub-nuclear domains raises the question on how the architecture of the nucleus modulates the transcriptional response. Here, we used fluorescence fluctuation analyses to quantitatively explore the organization of the glucocorticoid receptor (GR) in the interphase nucleus of living cells. We found that this ligand-activated transcription factor diffuses within the nucleus and dynamically interacts with bodies enriched in the coregulator NCoA-2, DNA-dependent foci and chromatin targets. The distribution of the receptor among the nuclear compartments depends on NCoA-2 and the conformation of the receptor as assessed with synthetic ligands and GR mutants with impaired transcriptional abilities. Our results suggest that the partition of the receptor in different nuclear reservoirs ultimately regulates the concentration of receptor available for the interaction with specific targets, and thus has an impact on transcription regulation.
Fermi surface topology and signature of surface Dirac nodes in LaBi
Authors: Singha Ratnadwip , Satpati Biswarup , Mandal Prabhat 
Published: July 2017

AbstractNovel topological state of matter is one of the rapidly growing fields in condensed matter physics research in recent times. While these materials are fascinating from the aspect of fundamental physics of relativistic particles, their exotic transport properties are equally compelling due to the potential technological applications. Extreme magnetoresistance and ultrahigh carrier mobility are two such major hallmarks of topological materials and often used as primary criteria for identifying new compounds belonging to this class. Recently, LaBi has emerged as a new system, which exhibits the above mentioned properties. However, the topological nature of its band structure remains unresolved. Here, using the magnetotransport and magnetization measurements, we have probed the bulk and surface states of LaBi. Similar to earlier reports, extremely large magnetoresistance and high carrier mobility have been observed with compensated electron and hole density. The Fermi surface properties have been analyzed from both Shubnikov-de Haas and de Haas-van Alphen oscillation techniques. In the magnetization measurement, a prominent paramagnetic singularity has been observed, which demonstrates the non-trivial nature of the surface states in LaBi. Our study unambiguously confirms that LaBi is a three-dimensional topological insulator with possible linear dispersion in the gapped bulk band structure.
Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
Authors: Santos-Almeida Fernanda Machado , Domingos-Souza Gean , Meschiari César A. , Fávaro Laura Campos , Becari Christiane , Castania Jaci A. , Lopes Alexandre , Cunha Thiago M. , Moraes Davi J. A. , Cunha Fernando Q. , Ulloa Luis , Kanashiro Alexandre , Tezini Geisa C. S. V. , Salgado Helio C. 
Published: July 2017

AbstractRecent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6). By contrast, the chemoreflex stimulation increases the plasma levels of anti-inflammatory cytokine interleukin 10 (IL-10). This chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sympathetic - propranolol - or parasympathetic - methylatropine – signals. The chemoreflex stimulation as well as the surgical and pharmacological procedures were confirmed by real-time recording of hemodynamic parameters [pulsatile arterial pressure (PAP) and heart rate (HR)]. These results reveal, in conscious animals, a novel mechanism of neuromodulation mediated by the carotid chemoreceptors and involving both the sympathetic and parasympathetic systems.
Probing the magnetic profile of diluted magnetic semiconductors using polarized neutron reflectivity
Authors: Luo X. , Tseng L. T. , Lee W. T. , Tan T. T. , Bao N. N. , Liu R. , Ding J. , Li S. , Lauter V. , Yi J. B. 
Published: July 2017

AbstractRoom temperature ferromagnetism has been observed in the Cu doped ZnO films deposited under an oxygen partial pressure of 10−3 and 10−5 torr on Pt (200 nm)/Ti (45 nm)/Si (001) substrates using pulsed laser deposition. Due to the deposition at relatively high temperature (873 K), Cu and Ti atoms diffuse to the surface and interface, which significantly affects the magnetic properties. Depth sensitive polarized neutron reflectometry method provides the details of the composition and magnetization profiles and shows that an accumulation of Cu on the surface leads to an increase in the magnetization near the surface. Our results reveal that the presence of the copper at Zn sites induces ferromagnetism at room temperature, confirming intrinsic ferromagnetism.
High Contrast Far-Field Radiative Thermal Diode
Authors: Ghanekar Alok , Xiao Gang , Zheng Yi 
Published: July 2017

AbstractWe propose a theoretical concept of a far-field radiative thermal rectification device that uses a phase change material to achieve a high degree of asymmetry in radiative heat transfer. The proposed device has a multilayer structure on one side and a blackbody on other side. The multilayer structure consists of transparent thin film of KBr sandwiched between a thin film of VO2 and a reflecting layer of gold. When VO2 is in its insulating phase, the structure is highly reflective due to the two transparent layers on highly reflective gold. When VO2 is in the metallic phase, Fabry-Perot type of resonance occurs and the tri-layer structure acts like a wide-angle antireflection coating achieved by destructive interference of partially reflected waves making it highly absorptive for majority of spectral range of thermal radiation. The proposed structure forms the active part of configuration that acts like a far-field radiative thermal diode. Thermal rectification greater than 11 is obtained for a temperature bias of 20 K, which is the highest rectification ever predicted for far-field radiative diode configurations.
Silicon-Based Reagents for Difluoromethylation and Difluoromethylenation Reactions
Authors: Krishnamoorthy Sankarganesh , Prakash G. 
Published: July 2017

There have been significant developments in the area of perfluoroalkyl group transfer using silicon reagents, specifically in nucleo­philic trifluoromethylation. The mild and versatile activation conditions bestow significant synthetic prowess to the silicon reagents in the area of fluoroalkylations. Owing to the importance of difluoromethylene (CF2) containing compounds in pharmaceuticals, materials, and agrochemicals, several CF2 group transfer methods using related silicon reagents have been developed and studied in detail. This review summarizes the recent developments and trends in this area.1	Introduction2	Trimethyl(trifluoromethyl)silane (Me3SiCF3)3	(Difluoromethyl)trimethylsilane (Me3SiCF2H)3.1	Nucleophilic Addition3.2	Nucleophilic Substitution3.3	Nucleophilic Difluoromethylation of Electron-Deficient Hetero­cycles3.4	Metal-Mediated Cross Coupling3.5	Oxidative Coupling of Terminal Alkynes4	Post-functionalizable Difluoromethyl Transfer Reagents4.1	(Chlorodifluoromethyl)trimethylsilane (Me3SiCF2Cl)4.2	(Bromodifluoromethyl)trimethylsilane (Me3SiCF2Br)4.3	[Difluoro(iodo)methyl]trimethylsilane (Me3SiCF2I)4.4	[Difluoro(phenylthio)methyl]trimethylsilane (Me3SiCF2SPh)4.5	[Difluoro(phenylsulfonyl)methyl]trimethylsilane (Me3SiCF2SO2Ph)4.6	Diethyl [Difluoro(trimethylsilyl)methyl]phosphonate
[Me3SiCF2P(O)(OEt)2]4.7	Ethyl Difluoro(trimethylsilyl)acetate (Me3SiCF2CO2Et)4.8	Difluoro(trimethylsilyl)acetamides (Me3SiCF2CONR2)4.9	Difluoro(trimethylsilyl)acetonitrile (Me3SiCF2CN)5	Others6	Conclusions
Pediatric Short Bowel Syndrome: Predicting Four-Year Outcome after Massive Neonatal Resection
Authors: Capriati Teresa , Giorgio Daniela , Fusaro Fabio , Candusso Manila , Schingo Paolo , Caldaro Tamara , Laureti Francesca , Elia Domenica , Diamanti Antonella 
Published: July 2017

Objectives The aim of this study was to ascertain predictors of survival, liver disease (LD), and enteral autonomy 48 months after resection in neonatal short bowel syndrome (SBS) patients with residual small bowel length (SBL) ≤40 cm.
Patients and Methods Medical records of all SBS patients followed up between 1996 and 2016 were retrospectively reviewed. Survival rate, prevalence of LD, and of enteral autonomy were evaluated.
Results Forty-seven patients were included, and 43 were still alive at the end of the study period, with cumulative 48-month survival of 91.5%. Twenty-one (45%) patients developed LD, all within the first 6 months. On the final follow-up visit, three (6%) patients were still jaundiced and progressed toward end-stage LD. LD prevalence was higher in patients with recurrent bloodstream infections (odds ratio [OR] 5.4, 95% confidence interval [CI] 1.5–19.3). Of the 43 surviving patients, 22 (51%) had enteral autonomy 48 months after resection. The probability of weaning off parenteral nutrition (PN) was strongly correlated with the remaining SBL.
Conclusion Survival of patients who have undergone neonatal massive small bowel resection has improved in recent years. Multidisciplinary strategies can improve the course of LD, but not the probability of weaning off PN, which seems to be strongly dependent on the anatomical profile of residual bowel. Therefore, the primary surgical approach should be as conservative as possible to gain even small amounts of intestinal length, which may be crucial in promoting intestinal adaptation.
Treatment with Circular External Fixation of Bicondylar Tibial Fractures: Potential in Accurate Reduction and Efficacy on Functional Results
Authors: Vulcano Ettore , Bettella Lorenzo , Tasarib Rohoman , Tondolo Tania , Sala Francesco , Lovisetti Giovanni 
Published: July 2017

AbstractSurgical reconstruction of bicondylar tibial fractures with external fixation relies on indirect fracture reduction that could affect anatomical restoration. The aim of the present study is to evaluate the radiographic and clinical outcomes of tibial bicondylar fractures treated with circular external fixation. A total of 20 bicondylar fractures of the proximal tibia in 20 patients treated with circular external fixation were included in the study. Two fractures were open. Mean clinical and radiographic follow-up was 37.3 months after frame removal. Angular, translation, and length deformities were assessed on nonweight-bearing anteroposterior, lateral, and two 45 degrees oblique views. The medial proximal tibia (MPTA) and posterior proximal tibia angles (PPTA) were calculated in all cases. The condylar widening was calculated in relation to the width of the femoral condyles. Joint depressions or gaps of the articular surface were identified on the four views of the knee. The modified Hospital for Special Surgery (HSS) knee scoring system was used for clinical evaluation. The MPTA was good in 18 (90%) and fair in 2 patients (10%). The PPTA was good in 13 (65%), fair in 6 (30%), and poor in 1 patient (5%). The articular reduction was good in 12 (60%) and fair in 8 patients (40%). The condylar widening was good in 15 (75%) and fair in 5 patients (25%). Mechanical axis deviation was within the normal range in 11/12 patients (91.7%). All fractures consolidated. One deep infection was successfully treated with local debridement, the mean modified HSS knee score at the latest follow-up was 90.5 (range: 67–100). Articular reconstruction and tibia alignment based on radiographic evaluation in the present study, along with functional results compare favorably with those of external and internal fixation presented in the literature.
Biomechanics and Microstructural Analysis of the Mouse Knee and Ligaments
Authors: Carballo Camila , Hutchinson Ian , Album Zoe , Mosca Michael , Hall Arielle , Rodeo Scott , Ying Liang , Deng Xiang-Hua , Rodeo Scott 
Published: July 2017

AbstractThe purpose of this study is to determine the feasibility of using murine models for translational study of knee ligament injury, repair, and reconstruction. To achieve this aim, we provide objective, quantitative data detailing the gross anatomy, biomechanical characteristics, and microscopic structure of knee ligaments of 44 male mice (C57BL6, 12 weeks of age). Biomechanical testing determined the load-to-failure force, stiffness, and the site of ligament failure for the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), and the medial and lateral collateral ligaments (MCL and LCL). These data are complemented by histological characterization of each of the knee ligaments. In addition, the osseous morphology of the mouse knee was examined using high-resolution nanofocus computed tomography (CT), while standard micro-CT was employed to measure bone morphometrics of the distal femur and proximal tibia. Collectively, our findings suggest that the gross anatomy of the mouse knee is similar to the human knee despite some minor differences and features unique to the murine knee. The ACL had the highest load to failure (5.60 ± 0.75 N), the MCL (3.33 ± 1.45 N), and the PCL (3.45 ± 0.84 N) were similar, and the LCL (1.44 ± 0.37 N) had the lowest load to failure and stiffness. Murine models provide a unique opportunity to focus on biological processes that impact ligament pathology and healing due to the availability of transgenic strains. Our data support their use as a translational platform for the in vivo study of ligament injury, repair, and reconstruction.