bluuebunny/crossref_metadata_2025_split huggingface dataset:
The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells
Authors: Croft W. , Pounds R. , Jeevan D. , Singh K. , Balega J. , Sundar S. , Williams A. , Ganesan R. , Kehoe S. , Ott S. , Zuo J. , Yap J. , Moss P. 
Published: September 2024

AbstractDisease recurrence following chemotherapy is a major clinical challenge in ovarian cancer (OC), but little is known regarding how the tumour epigenome regulates transcriptional programs underpinning chemoresistance. We determine the single cell chromatin accessibility landscape of omental OC metastasis from treatment-naïve and neoadjuvant chemotherapy-treated patients and define the chromatin accessibility profiles of epithelial, fibroblast, myeloid and lymphoid cells. Epithelial tumour cells display open chromatin regions enriched with motifs for the oncogenic transcription factors MEIS and PBX. Post chemotherapy microenvironments show profound tumour heterogeneity and selection for cells with accessible chromatin enriched for TP53, TP63, TWIST1 and resistance-pathway-activating transcription factor binding motifs. An OC chemoresistant tumour subpopulation known to be present prior to treatment, and characterised by stress-associated gene expression, is enriched post chemotherapy. Nuclear receptors RORa, NR2F6 and HNF4G are uncovered as candidate transcriptional drivers of these cells whilst closure of binding sites for E2F2 and E2F4 indicate post-treated tumour having low proliferative capacity. Delineation of the gene regulatory landscape of ovarian cancer cells surviving chemotherapy treatment therefore reveals potential core transcriptional regulators of chemoresistance, suggesting novel therapeutic targets for improving clinical outcome.
Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations
Authors: You Qinglong , Feng Xiang , Cai Yi , Baylin Stephen B. , Li Huilin 
Published: September 2024

AbstractThe human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as cancer, inflammation, and neurodegenerative diseases. Previous structural studies have used a truncated protein and short linear DNA, so it has been unclear how full-length OGG1 operates on longer DNA or on nucleosomes. Here we report cryo-EM structures of human OGG1 bound to a 35-bp long DNA containing an 8-oxoG within an unmethylated Cp-8-oxoG dinucleotide as well as to a nucleosome with an 8-oxoG at super-helical location (SHL)-5. The 8-oxoG in the linear DNA is flipped out by OGG1, consistent with previous crystallographic findings with a 15-bp DNA. OGG1 preferentially binds near dsDNA ends at the nucleosomal entry/exit sites. Such preference may underlie the enzyme’s function in DNA double-strand break repair. Unexpectedly, we find that OGG1 bends the nucleosomal entry DNA, flips an undamaged guanine, and binds to internal nucleosomal DNA sites such as SHL-5 and SHL+6. We suggest that the DNA base search mechanism by OGG1 may be chromatin context-dependent and that OGG1 may partner with chromatin remodelers to excise 8-oxoG at the nucleosomal internal sites.
Photon upconversion crystals doped bacterial cellulose composite films as recyclable photonic bioplastics
Authors: Bharmoria Pankaj , Naimovičius Lukas , Abol-Fotouh Deyaa , Miroshnichenko Mila , Lekavičius Justas , De Luca Gabriele , Saeed Umair , Kazlauskas Karolis , Candau Nicolas , Baronas Paulius , Roig Anna , Moth-Poulsen Kasper 
Published: September 2024

AbstractBiopolymers currently utilized as substitutes for synthetic polymers in photonics applications are predominantly confined to linear optical color responses. Herein we expand their applications in non-linear optics by integrating with triplet-triplet annihilation photon upconversion crystals. A photon upconverting biomaterial is prepared by cultivating Pd(II) meso-tetraphenyl tetrabenzoporphine: 9,10-diphenyl anthracene (sensitizer: annihilator) crystals on bacterial cellulose hydrogel that serves both as host and template for the crystallization of photon upconversion chromophores. Coating with gelatin improves the material’s optical transparency by adjusting the refractive indices. The prepared material shows an upconversion of 633 nm red light to 443 nm blue light, indicated by quadratic to linear dependence on excitation power density (non-linearly). Notably, components of this material are physically dis-assembled to retrieve 66 ± 1% of annihilator, at the end of life. Whereas, the residual clean biomass is subjected to biodegradation, showcasing the sustainability of the developed photonics material.
An efficient multi‐probe enabled midfield over‐the‐air test method for 5G base station antenna pattern reconstruction
Authors: An Xudong , Wang Yiwen , Zhang Qinjuan , Wang Weimin , Liu Yuanan 
Published: September 2024

AbstractWith the accelerated deployment of 5G massive multi‐input multi‐output (MIMO)‐structured base stations (BSs), accurate and efficient testing of massive MIMO arrays is essential to ensure that the 5G massive MIMO antenna array can perform as expected. The increasing trend of both antenna element and array physical size makes massive MIMO antenna pattern measurement in the direct‐far‐field OTA environment unrealistic due to the signal attenuation, long measurement time, and ultra‐high test system construction cost. Therefore, the necessity of a compact, efficient, low‐complex, yet accurate OTA test method is evident, especially for 5G massive MIMO BS arrays. This paper proposes a novel multi‐probe‐enabled midfield (MF) OTA test method for 5G massive MIMO devices in compact measurement settings where antenna pattern measurement can be efficiently performed. The detailed theoretical analysis for the 5G massive MIMO array MF antenna pattern reconstruction method is presented, and the simulated validation results based on the typical 5G BS antenna arrays are provided and analysed, which demonstrate the effectiveness of the proposed MF OTA test method and can provide insights into the radio frequency parametric measurement for 5G massive MIMO devices.
Distributed flexible resource regulation strategy for residential communities based on deep reinforcement learning
Authors: Xu Tianyun , Chen Tao , Gao Ciwei , Song Meng , Wang Yishen , Yuan Hao 
Published: September 2024

AbstractIn an era characterized by the rapid proliferation of distributed flexible resources (DFRs), the development of customized energy management and regulation strategies has attracted significant interest from the field. The inherent geographical dispersion and unpredictability of these resources, however, pose substantial barriers to their effective and computationally tractable regulation. To address these impediments, this paper proposes a deep reinforcement learning‐based distributed resource energy management strategy, taking into account the inherent physical and structural constraints of the distribution network. This proposed strategy is modelled as a sequential decision‐making framework with a Markov decision process, informed by physical states and external information. In particular, targeting the community energy management system for critical public infrastructure and community holistic benefits maximization, the proposed approach proficiently adapts to fluctuations in resource variability and fluctuating market prices, ensuring intelligent regulation of distributed flexible resources. Simulation and empirical analysis demonstrate that the proposed deep reinforcement learning‐based strategy can improve the economic benefits and decision‐making efficiency of distributed flexible resource regulation while ensuring the security of distribution network power flow.
Prävention orofazialer DysfunktionenOrale Entwicklung als
Chance
Authors: Furtenbach Mathilde 
Published: September 2024

ZusammenfassungPrävention von myofunktionellen Störungen ist immer auch Prävention von Zahn- und
Kieferfehlstellungen. Die Erfahrungen in der logopädischen Praxis konnten
zeigen, dass das Wissen über die vollständige orale Entwicklung allgemein eher
gering ist und vor allem der Einfluss des Umweltfaktors (Epigenetik) über die
Nahrungsaufnahme und den Modus des Atmens kaum thematisiert wird. Eltern würden
manches anders machen, „wenn sie es früher gewusst hätten“.Die häufigsten Dysfunktionen, die in der logopädischen Praxis beobachtet werden,
weisen auf Defizite und Störfaktoren in den beiden ersten Lebensjahren hin. Der
letzte Abschnitt ist den 7 Funktionen gewidmet, die für die orale Entwicklung
von Bedeutung sind. Wenn bedacht wird, dass ein großer Anteil von Dysgnathien
ätiologisch exogen hervorgerufen wird, und kaum ein Kind ein eugnathes Gebiss
hat, lohnt es sich, über neue Wege und Möglichkeiten der Prävention
nachzudenken.Das motivierte mich, für Eltern und für alle möglichen Fachleute und für
Interessierte einen handlichen, reich bebilderten Ratgeber zusammenzustellen,
der die Bedeutung der oralen Funktionen Atmen, Saugen, Explorieren, Kauen,
Schlucken und Sprechen in den ersten Lebensjahren beschreibt [6]. Die 7 oralen
Funktionen stellen einen Leitfaden dar, der Information und Orientierung gibt.
Orale Entwicklung soll als Chance gesehen werden, die ergriffen werden kann.Diese Idee könnte die Grundlage für einen ausbaufähigen Aufklärungsprozess sein,
der sich mit der Prävention von myofunktionellen Störungen und Zahn- und
Kieferfehlstellungen beschäftigt. Damit soll auch das Gespräch mit den Eltern,
unter den Fachdisziplinen und mit Personen, die mit kleinen Kindern arbeiten
oder leben, gefördert oder erleichtert werden.
Complete Clinical Orthodontics: Überblick über die
Behandlungsmechanik
Authors: Secchi Antonino G. 
Published: September 2024

ZusammenfassungDie Behandlungsmechanik war für praktisch tätige Kieferorthopäden schon immer von
besonderem Interesse. Von Anfang an wurde nach den besten, schnellsten,
konsistenteren und einfachsten Möglichkeiten gesucht, Zahnfehlstellungen bei
Patienten zu korrigieren. Diese kontinuierliche Suche hat es ermöglicht, dass
neue Technologien, wenn auch manchmal langsam, in unserer täglichen Praxis
Eingang finden, bis sie schließlich zur Routine werden. Daher verändert sich
unsere Arbeitsweise immer wieder durch neue Materialien, Verbesserungen im
Gerätedesign und innovative Ideen und Technologien. Für den modernen
Kieferorthopäden ist es wichtig, über aktuelle Änderungen informiert zu sein, um
für sich das Beste auszuwählen.In jüngere Zeit hat es bei festsitzenden kieferorthopädischen Apparaturen eine
interessante Vermischung von Technologien gegeben, die schon seit Jahrzehnten
existieren, wie beispielsweise die Straight-Wire-Technik (SWA) [1–4],
selbstligierende Brackets (SLB) [5] und wärmeaktivierte Drahtbögen mit geringer
Auslenkung. Diese Integration stellt meiner Meinung nach eine Verbesserung dar,
die bei richtiger Anwendung die kieferorthopädische Praxis erleichtern kann. Das
Hauptanliegen dieses Artikels ist es, die Konzepte der Behandlungsmechanik im
CCO-System vorzustellen. Ich werde einige wichtige Merkmale der interaktiven SLB
besprechen, die, kombiniert mit bestimmten Bögen und in einer bestimmten
Abfolge, dabei helfen können, unterschiedliche Arten von Fehlstellungen zu
korrigieren. In diesem Zusammenhang werden wichtige Merkmale der interaktiven
SLB, eine bestimmte Methode (CCO Rx), sowie die 3 Phasen der Behandlungsmechanik
besprochen. Außerdem werden Themen wie die Koordination der Zahnbögen, die
Nivellierung der Okklusionsebene und vertikale Probleme angesprochen.
Management of Therapeutic-intensity Unfractionated Heparin: A Narrative Review on Critical Points
Authors: Gouin-Thibault Isabelle , Mansour Alexandre , Hardy Michael , Guéret Pierre , de Maistre Emmanuel , Siguret Virginie , Cuker Adam , Mullier François , Lecompte Thomas 
Published: September 2024

Nowadays, unfractionated heparin (UFH) use is limited to selected patient groups at high risk of both bleeding and thrombosis (patients in cardiac surgery, in intensive care unit, and patients with severe renal impairment), rendering its management extremely challenging, with many unresolved questions despite decades of use.In this narrative review, we revisit the fundamental concepts of therapeutic anticoagulation with UFH and address five key points, summarizing controversies underlying the use of UFH and discussing the few recent advances in the field: (1) laboratory tests for UFH monitoring have significant limitations; (2) therapeutic ranges are not well grounded; (3) the actual influence of antithrombin levels on UFH's anticoagulant activity is not well established; (4) the concept of UFH resistance lacks supporting data; (5) scarce data are available on UFH use beyond acute venous thromboembolism.We therefore identified key issues to be appropriately addressed in future clinical research: (1) while anti-Xa assays are often considered as the preferred option, we call for a vigorous action to improve understanding of the differences between types of anti-Xa assays and to solve the issue of the usefulness of added dextran; (2) therapeutic ranges for UFH, which were defined decades ago using reagents no longer available, have not been properly validated and need to be confirmed or reestablished; (3) UFH dose adjustment nomograms require full validation.
Inherited Variants in the COL11A, COL1A, COL5A1, COMP, GSTM1 Genes
and the Risk of Carpal Tunnel Syndrome
Authors: Zyluk Andrzej , Debniak Tadeusz , Flicinski Filip , Rudnicka Helena 
Published: September 2024

AbstractThe pathogenesis of most cases of carpal tunnel syndrome is not clearly defined.
There are some aspects of the disease that suggest a potential effect of genetic
predispositions. Mutations (variants) within the genes encoding various subtypes
of collagen synthesis, oligomerisation in the endoplasmic reticulum and
inactivation of reactive oxygen species may be involved in the development of
carpal tunnel syndrome. The objective of this study was to determine the role of
DNA alterations within the COL11A, COL1A, COL5A1, COMP and GSTM1 genes in the
pathogenesis of carpal tunnel syndrome based on a Polish population. Study
design. In the discovery phase, a total of 96 patients with familial aggregation
of CTS were genotyped using a Next Generation Sequencing panel in order to find
possible mutations within the studied genes. The potential pathogenicity of the
detected variants was investigated using the predictions of several in-silico
algorithms and the TaqMan technology. In the association phase of the study, a
group of 345 CTS patients and 1035 healthy controls were genotyped. Results. A
total of 35 splice-site or exonic non-synonymous variants were detected by NGS.
We did not identify any clearly pathogenic or likely pathogenic alternations.
The 30 variants were identified as benign or likely benign. Five missense
changes were predicted as VUS and selected for association study. The COL5A1
c.1595 C>T (p.Ala532Val) was detected in one out of 345 cases and three out
of 1035 controls (P=1, OR=1); this indicates that the variant is a neutral
alteration. Four remaining variants – c.2840 C>A, c.5395 G>A,
c.1331 C>G, c.1590 C>A – were present in none out of the 345 CTS patients
and none out of 1035 controls. Conclusion. The main finding of this study was
that there was no independent association between the variants of five examined
genes and carpal tunnel syndrome. Four uncertain variants were identified that
seem to be extremely rare in the Polish population.
Neonatal Outcomes at 2 Years following Expectant Management of Previable Premature Prelabor Rupture of Membranes at a Single Center
Authors: Cate Jennifer J.M. , Chu Allison , Lambert Katherine , Sugrue Ronan , Wheeler Sarahn , Grace Matthew R. , Adams William A. , Dotters-Katz Sarah 
Published: September 2024

Previable premature prelabor rupture of membranes (pPPROM) can lead to significant maternal and neonatal morbidity and mortality. Limited literature exists describing long-term outcomes in neonates surviving pPPROM. Our study describes 2-year survival and outcomes after expectantly managed pPPROM at a single, tertiary, academic center. This is a retrospective review including individuals with pPPROM defined as membrane rupture before 240/7 weeks who were candidates and opted for expectant management at a single tertiary academic center between 2013 and 2022. Patients were included if they delivered after 22 weeks. Patients opting for termination, with contraindication to expectant management or who chose expectant management without planned neonatal resuscitation at birth were excluded. Electronic records of patients and associated neonates were reviewed for demographic information, PPROM management, and neonatal outcomes at 2 years including gastrointestinal, respiratory, cognitive, motor, and hearing or vision issues. Descriptive statistical analysis was performed. Of 111 pregnancies with pPPROM, 50(45%) pregnant individuals met inclusion criteria (46 singletons; 4 multiples [3 twins, 1 set of quads]). Of 46 singletons, 31 (67%) survived to 2 years with 1(3%) alive but less than 2 years. In 3/4 (75%) twin gestations, both twins survived to 2 years. A total of 3/4 (75%) quadruplets survived to 2 years. Most surviving infants (95.0%, n = 38) had at least one documented adverse outcome. A total of 55.0% (n = 22) of neonates had gross motor delay, and 77.5% (n = 31) had documented speech delay. Most had respiratory issues with reactive airway disease most common (22.5% n = 9). Gastrointestinal issues were common with gastrostomy tube in 32.5% (n = 13) and short gut syndrome in 15% (n = 6). Over half of neonates with expectantly managed pPPROM survived with high rates of adverse outcomes with over half with documented gross motor and speech delay present at 2 years. Respiratory and gastrointestinal issues were also common. These data provide information for important patient counseling on long-term outcomes in expectantly managed pPPROM.
Key Points
Messen und Trainieren therapeutischer Kompetenzen
Authors: Gumz Antje 
Published: September 2024

ZusammenfassungDer Artikel gibt einen Überblick über unsere Forschungsansätze zu therapeutischen
Kompetenzen im Hinblick auf drei übergeordnete Fragestellungen. Die erste
Fragestellung befasst sich damit, wie ein kompetenter Umgang mit der Übertragung
und Gegenübertragung im Kontext von Alliance Ruptures gelingt. Diesbezügliche
Forschungen zum Allianzfokussierten Training sowie zur subjektiven
Gegenübertragung werden vorgestellt. Im Bereich der zweiten Fragestellung geht
es um allgemeine interpersonelle Kompetenzen von Therapeuten. Unsere hierzu
skizzierten Forschungsansätze betreffen das Konstrukt der interpersonellen
Fähigkeiten (Facilitative Interpersonal Skills, FIS) und das Messen dieser
Fähigkeiten mit der FIS-Übung. In diesem Themenbereich fokussieren wir auch
darauf, mit welchen Eigenschaften hohe interpersonelle Fähigkeiten einhergehen
und durch welche linguistischen und phonetischen Merkmale Therapeutenäußerungen
gekennzeichnet sind, die als interpersonell kompetent eingestuft werden. Zudem
untersuchen wir die Neigung von Therapeuten, ihre interpersonellen Fähigkeiten
zu überschätzen (Self-Assessment Bias). Die dritte Fragestellung betrifft die
therapeutische Kompetenz, Techniken anzuwenden und hilfreiche
Veränderungsprozesse entstehen zu lassen. Vorgestellt werden ein Instrument zum
Erfassen verbaler Techniken (Psychodynamische Interventionsliste) sowie unsere
Forschungsansätze, die auf das Beschreiben und Messen von Veränderungsprinzipien
(Mediators of change) fokussieren.
Solvent-Free Approaches for the Synthesis of Lophine Derivatives
Authors: Desai Shiv R. , Modha Sachin G. 
Published: September 2024

AbstractSolvent-free synthesis comes with many advantages such as cost reduction, waste reduction, ease of operation, sustainability, environmentally benign operations, etc. These benefits have prompted many chemists to develop new protocols for solvent-free synthesis of various interesting chemical compounds. One such class of compounds is 2,4,5-triarylimidazoles, commonly known as lophines due to their applications in materials science, chemo- and bio-sensors, and pharmacology. This article focuses on solvent-free synthesis of lophine derivatives via different protocols, including the use of inorganic-, organic-, and biocatalysts; solid-supported catalysts; microwave-mediated heating; and grinding.
Strategies for the Total Synthesis of Fucoxanthin from a Commercial Perspective
Authors: Gupta Sayan Dutta , Pan Cheol-Ho 
Published: September 2024

AbstractFucoxanthin, the light-harvesting pigment of various algae, has shown promising biological activity in pre-clinical and clinical models. It has also received marketing approval as a nutraceutical and cosmetic ingredient in the USA and other countries. The commercial synthesis of this natural ingredient assumes significance because of various drawbacks (low yield, patent infringement, longer duration of cultivation, etc.) associated with its extraction and isolation procedures. This review is intended to provide an appraisal of the total syntheses of fucoxanthin reported to date along with a detailed explanation of the commercially viable approach. Finally, we briefly discuss the future of research for the total synthesis of fucoxanthin.
Catalyst-Controlled Strategies to Override the Bond Dissociation Energy-Driven Selectivity of Benzylic C(sp3)–H Insertions
Authors: Sircoglou Marie , Dauban Philippe , Brunard Erwan , Boquet Vincent , Bissonnier Théo , Saget Tanguy , Carrizo E. Daiann Sosa 
Published: September 2024

AbstractCatalytic C(sp3)–H insertion reactions of arylalkanes generally proceed at the benzylic position as a consequence of the lower bond dissociation energy (BDE) of the corresponding C–H bond. This account gives a brief overview of recent studies aimed at designing catalyst-controlled amination reactions to go beyond this BDE-driven selectivity. They permit the selective conversion of neutral C–H bonds with a BDE greater than 95 kcal mol–1 for the formation of alkylamines.1	Introduction2	Catalyst-Controlled Site-Selective C–H Insertion Reactions3	Catalyst-Controlled Intermolecular Amination of Nonactivated C–H Bonds of Arylalkanes4	Conclusion
Second Recurrence of Aggressive Angiomyxoma of Labia Majora in a 34-Year-Old Woman: A Case Report and Review of Literature
Authors: Shrigiriwar Mansi , Singh Shobhana 
Published: September 2024

AbstractAggressive angiomyxoma (AAM) is a rare, slow-growing, benign neoplasm with high recurrence and local invasion. It is usually asymptomatic and frequently presents as a mass affecting the perineal and pelvic regions of women in reproductive age group. We present a rare case of a 34-year-old woman with second recurrence of a giant AAM arising from labia majora. The patient presented with a slow-growing pedunculated mass (around 20 × 12 cm) over the right labia majora for the past 1 year. In the last 10 years, she was operated on two different occasions (2013 and 2015) for similar lesion and was a confirmed case of AAM. Ultrasound of the lesion and magnetic resonance imaging of the abdominopelvic region was suggestive of recurrent AAM. The patient underwent en bloc dissection of the tumor with negative margin. Histopathological examination confirmed the diagnosis of recurrent AAM. En bloc dissection with negative margin leads to complete removal of tumor mass. However, long-term follow-up with annual magnetic resonance imaging is advised.