bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recovery From COVID-19–Related Disruptions in Cancer Detection
Authors: Kim Uriel , Rose Johnie , Carroll Bryan T. , Hoehn Richard S. , Chen Eric , Bordeaux Jeremy S. , Koroukian Siran M. 
Published: October 2024

ImportanceThe COVID-19 pandemic impacted the timely diagnosis of cancer, which persisted as the second leading cause of death in the US throughout the pandemic.ObjectiveTo evaluate the disruption and potential recovery in cancer detection during the first (2020) and second (2021) years of the COVID-19 pandemic.Design, Setting, and ParticipantsThis cross-sectional study involved an epidemiologic analysis of nationally representative, population-based cancer incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program. Included patients were diagnosed with incident cancer from January 1, 2000, through December 31, 2021. The analysis was conducted in May 2024 using the April 2024 SEER data release, which includes incidence data through December 31, 2021.ExposuresDiagnosis of cancer during the first 2 years of the COVID-19 pandemic (2020, 2021).Main Outcomes and MeasuresDifference between the expected and observed cancer incidence in 2020 compared with 2021, with additional analyses by demographic subgroups (sex, race and ethnicity, and age group) and community (county-level) characteristics.ResultsThe analysis included 15 831 912 patients diagnosed with invasive cancer between 2000 and 2021, including 759 810 patients in 2020 and 825 645 in 2021. The median age was 65 years (IQR, 56-75 years), and 51.0% were male. The percentage difference between the expected and observed cancer incidence was −8.6% (95% CI, −9.1% to −8.1%) in 2020, with no significant difference in 2021 (−0.2%; 95% CI, −0.7% to 0.4%). These translated to a cumulative (2020-2021) deficit in observed vs expected cases of −127 931 (95% CI, −139 206 to −116 655). Subgroup analyses revealed that incidence rates remained substantially depressed from expected rates into 2021 for patients living in the most rural counties (−4.9%; 95% CI, −6.7% to −3.1%). The cancer sites with the largest cumulative deficit in observed vs expected cases included lung and bronchus (−24 940 cases; 95% CI, −28 936 to −20 944 cases), prostate (−14 104 cases; 95% CI, −27 472 to −736 cases), and melanoma (−10 274 cases; 95% CI, −12 825 to −7724 cases).Conclusions and RelevanceThis cross-sectional study of nationally representative registry data found that cancer incidence recovered meaningfully in 2021 following substantial disruptions in 2020. However, incidence rates need to recover further to address the substantial number of patients with undiagnosed cancer during the pandemic.
Limitations in Activities of Daily Living Among Individuals With Systemic Lupus Erythematosus
Authors: Plantinga Laura C. , Bowling C. Barrett , Pearce Bradley D. , Hoge Courtney , Dunlop‐Thomas Charmayne , Lim S. Sam , Katz Patricia P. , Yazdany Jinoos 
Published: October 2024

ObjectiveWe aimed to estimate the burden and identify potential correlates of limitations in activities of daily living (ADLs) among persons with systemic lupus erythematosus (SLE).MethodsIndividuals with SLE were recruited from a population‐based cohort (October 2019 to May 2022) and reported their ability to independently perform various instrumental ADLs (IADLs) and basic ADLs (BADLs) via survey. Limitations were defined as having at least some difficulty performing at least one of the IADLs or BADLs. Descriptive statistics were calculated, and associations (adjusted odds ratios [aORs]) of various participant characteristics with IADL and BADL limitations were assessed with logistic regression adjusting for age, sex, and race.ResultsThe mean age of the 436 participants was 46.2 years; most were female (91.7%) and Black (82.8%). More than half (56.2%) reported limitations in IADLs, most commonly housekeeping (50.7%), laundry (37.2%), and shopping (33.0%); 43.8% reported limitations in independently performing BADLs, most commonly transferring (26.6%), bathing (25.3%), dressing (24.4%), and continence (22.0%). Higher disease activity (greater than or equal to vs less than the median) was strongly associated with IADLs (aOR 6.49, 95% confidence interval [CI] 4.15–10.2) and BADLs (aOR 7.35, 95% CI 4.70–11.5), along with higher depression and perceived stress scores, lower educational attainment and income, and older age.ConclusionIADL and BADL limitations may be common in individuals with SLE and more prevalent among those who report higher disease activity, depressive symptoms, and lower income and among those who are older. Research to support evidence‐based strategies for improvement in quality of life and maintenance of independence in the older SLE population is warranted.image
Distributed Consensus Filtering Over Sensor Networks With Asynchronous Measurements
Authors: Hu Yanyan , Lin Xufeng , Peng Kaixiang 
Published: October 2024

ABSTRACTIn practical sensor networks, sensor nodes may operate with different sampling periods and initial sampling time instants, and their observations may also be nonuniform. Unfortunately, the research on distributed state estimation problems over such asynchronous sensor networks is very limited. Thus, this article focuses on the distributed consensus filtering problem over sensor networks with asynchronous measurements. First, the asynchronous measurement from each sensor is synchronized by the continuous‐time state evolution equation to a unified filtering fusion time instant within a given filtering period. After measurement synchronization, the statistical characteristics of measurement noise change. The cross‐correlations between the converted measurement noises are analyzed, as well as one‐step correlations between the converted measurement noises and the process noise. Second, an optimal asynchronous distributed consensus filter is designed based on synchronization measurements under the criterion of minimum mean‐square error with the above correlations between various types of noises taken into account. Meanwhile, a suboptimal distributed consensus filtering algorithm is further proposed to reduce computational complexity. Finally, based on the Lyapunov function method, the stability of the estimation error is theoretically demonstrated with an appropriate selection of consensus filtering gain and validated through simulations.
Linking Metastatic Potential and Viscoelastic Properties of Breast Cancer Spheroids via Dynamic Compression and Relaxation in Microfluidics
Authors: Tavasso Margherita , Bordoloi Ankur D. , Tanré Elsa , Dekker Sanne A. H. , Garbin Valeria , Boukany Pouyan E. 
Published: October 2024

AbstractThe growth and invasion of solid tumors are associated with changes in their viscoelastic properties, influenced by both internal cellular factors and physical forces in the tumor microenvironment. Due to the lack of a comprehensive investigation of tumor tissue viscoelasticity, the relationship between such physical properties and cancer malignancy remains poorly understood. Here, the viscoelastic properties of breast cancer spheroids, 3D (in vitro) tumor models, are studied in relation to their metastatic potentials by imposing controlled, dynamic compression within a microfluidic constriction, and subsequently monitoring the relaxation of the imposed deformation. By adopting a modified Maxwell model to extract viscoelastic properties from the compression data, the benign (MCF‐10A) spheroids are found to have higher bulk elastic modulus and viscosity compared to malignant spheroids (MCF‐7 and MDA‐MB‐231). The relaxation is characterized by two timescales, captured by a double exponential fitting function, which reveals a similar fast rebound for MCF‐7 and MCF‐10A. Both the malignant spheroids exhibit similar long‐term relaxation and display residual deformation. However, they differ significantly in morphology, particularly in intercellular movements. These differences between malignant spheroids are demonstrated to be linked to their cytoskeletal organization, by microscopic imaging of F‐actin within the spheroids, together with cell‐cell adhesion strength.
Advanced Design and 3D Printing Strategies With Alginate‐Nanoclay Nanocomposites: From Microstructure to Bioprinting
Authors: Hua Weijian , Zhang Cheng , Mitchell Kellen , Raymond Lily , Hensley Dale K. , Coulter Ryan , Bandala Erick , Chen Jihua , Do Changwoo , Zhao Danyang , Jin Yifei 
Published: October 2024

AbstractNanocomposites made from alginate and nanoclay are extensively applied for diverse biomedical applications. However, the lack of a clear understanding of the interactions between alginate and nanoclay makes it difficult to rationally design the nanocomposites for different material extrusion‐based 3D bioprinting strategies. Here, a combined analytical model is proposed to accurately predict the interaction mechanisms between alginate and nanoclay through small‐angle neutron scattering. These mechanisms are summarized into a phase diagram that can guide the design of alginate‐nanoclay nanocomposites for different bioprinting applications. The rheological properties of various nanocomposites are measured to validate the proposed interaction mechanisms at the macroscale. Accordingly, three representative extrusion‐based bioprinting strategies are linked with the nanocomposite design and applied to freeform fabricate complex structures. A roadmap is summarized to bridge the gap between biomaterial design and bioprinting processes, enabling the rapid and rational selection of biomaterial formula based on available 3D printing methods, and vice versa.
Curcumin inhibits oxidative stress and autophagy in C17.2 neural stem cell through ERK1/2 signaling pathways
Authors: Ruan Yuting , Luo Haoyu , Tang Jingyi , Ji Mengyao , Yu Dapeng , Yu Qun , Cao Zhiyu , Mai Yingren , Zhang Bei , Chen Yan , Liu Jun , Liao Wang 
Published: October 2024

AbstractObjectivesThis study investigates curcumin's neuroprotective role and its potential in promoting neurogenesis in progenitor cells within the brain. Notably, curcumin's antioxidant properties have been implicated in Alzheimer's disease treatment. However, the association between curcumin's antioxidative effects and its impact on neural stem cells (NSCs) remains to be elucidated.MethodsC17.2 neural stem cells were utilized as a model to simulate oxidative stress, induced by hydrogen peroxide (H2O2). We quantified the levels of superoxide dismutase (SOD), malondialdehyde (MDA), and intracellular reactive oxygen species (ROS), alongside the gene expression of SOD1 and SOD2, to assess intracellular oxidative stress. Additionally, Western blot analysis was conducted to measure the expressions of LC3‐II, Beclin‐1, and phosphorylated ERK (p‐ERK), thereby evaluating autophagy and ERK signaling pathway activation.ResultsTreatment with curcumin resulted in a reduction of MDA and ROS levels, suggesting a protective effect on NSCs against oxidative damage induced by H2O2. Furthermore, a decrease in the relative expressions of LC3‐II, Beclin‐1, and p‐ERK was observed post‐curcumin treatment.ConclusionsThe findings suggest that curcumin may confer protection against oxidative stress by attenuating autophagy and deactivating the ERK1/2 signaling pathways, which could contribute to therapeutic strategies for Alzheimer's disease.
The impact of education as a proxy for lifestyle habits on reducing the association with dementia prevalence in the Southern Region of Brazil
Authors: Lopes Marcos Antonio , Junior Alberto Stoppe , Neto Ylmar Correa , D'Orsi Eleonora 
Published: October 2024

AbstractObjectivesThis study aimed to investigate the prevalence of dementia among older adults from Florianópolis, in the Southern Region of Brazil.MethodsData were originally drawn from the Epifloripa Aging Cohort Study, a representative and community‐based survey designed to evaluate older people's health. This cross‐sectional study was conducted in two phases: the community‐screening phase, in which the Mini‐Mental State Examination and a multifunctional scale were administered to older subjects and close informants, respectively; and the hospital‐diagnosis phase, when the Cambridge Examination and the National Institute on Aging criteria were used. Adjustment for screening accuracy was made in order to estimate dementia prevalence.ResultsOf 1184 subjects evaluated in the community, 243 were screened for the diagnosis phase, in which 47 were identified with dementia, resulting in a crude prevalence of 4.5% (95% CI: 3.241–5.758) and an estimated prevalence of 9.2% (95% CI: 7.446–10.954). Dementia was associated with older ages, lower education levels, and the presence of stroke. Mild alcohol use (in comparison with no alcohol use), community‐group practice, internet use and a higher level of physical activity, rather than education, decreased the odds ratio for dementia. Education was directly associated with these lifestyle habits.ConclusionsPrevalence was lower than that in previous studies in the country, and multivariate analysis reinforced the importance of lifestyle in preventing cognitive disorders in the older population.
DFT Study on Copper‐Catalyzed Hydroboration of 1,3‐Diynes: Mechanism, Selectivity, and Comparison with Ruthenium
Authors: Zhang Lei , Li Shan , Wen Yanhui , Ma Xiaosi , Zhang Jie , Zhou Jianguo , Meng Xiangtai 
Published: October 2024

AbstractDensity functional theory calculations have been performed to explore the mechanism of copper‐catalyzed hydroboration of 1,3‐diyne with HBpin. The catalytic cycles are composed of three elementary processes in succession, namely, the generation of copper hydride species, migratory insertion and σ‐bond metathesis, among which the σ‐bond metathesis step is rate‐determining with a free‐energy barrier of 19.7 kcal/mol. The syn‐addition selectivity originates from the high barrier for converting (Z)‐product to (E)‐product. Effects of diphosphine ligands and substituents on the reactivity were also addressed. Lastly, this copper‐catalyzed hydroboration was compared with a related ruthenium‐catalyzed one, and the obtained results indicated that copper‐catalyzed hydroboration has a more favorable σ‐bond metathesis step and a more challenging migratory insertion step as compared to the ruthenium‐catalyzed counterpart. Wavefunction analyses were performed to understand the observed behaviors.
Boosting Alkaline Hydrogen Oxidation Kinetics through Interfacial Environments Induced Surface Migration of Adsorbed Hydroxyl
Authors: Men Yana , Tan Yue , Li Peng , Jiang Yaling , Li Lei , Su Xiaozhi , Men Xiaomei , Sun Xueping , Chen Shengli , Luo Wei 
Published: October 2024

AbstractConstructing bifunctional sites through heterojunction engineering to accelerate water formation has become a pivotal strategy to improve the alkaline hydrogen oxidation reaction (HOR) kinetics, which is mainly focused on the synergistic effect of neighboring sites and the energetics of the surface reaction steps. However, the roles of the surface migration of key intermediates that go beyond the bifunctional mechanism limited to neighboring atoms have usually been ignored. Using the heterostructured Ni3C−Ni catalyst as a model, we found that the rapid surface migration of OHad species from the positively charged Ni3C to the negatively charged Ni component played a decisive role in facilitating water formation. Such unprecedented surface migration of OHad is induced by the large discrepancy between the local surface charge densities and interfacial environments of the Ni3C and Ni components under operating conditions. Benefiting from this, the resultant Ni3C−Ni exhibited outstanding mass activity for the alkaline HOR, which was approximately 19‐fold and 21‐fold higher than those of Ni and Ni3C, respectively. These findings not only provide novel insights into the alkaline HOR mechanism of heterostructured catalysts but also open new avenues for developing advanced electrocatalysts for alkaline fuel cells.
Stabilization of the Compressed Planar Benzene Dianion in Inverse‐Sandwich Rare Earth Metal Complexes
Authors: Delano Francis , Demir Selvan 
Published: October 2024

AbstractFor the first time, the capture of the planar antiaromatic parent benzene dianion in between two trivalent rare earth (RE) metal cations (REIII), each stabilized by two guanidinate ligands, is reported. The synthesized inverse‐sandwich complexes [{(Me3Si)2NC(NiPr)2}2RE]2(μ‐η6 : η6‐C6H6), (RE=Y (1), Dy (2), and Er (3)) were crystallized from aprotic solvents and feature a remarkably planar parent benzene dianion, previously not encountered for any metal ion prone to low or absent covalency. The −2 charge localization at the benzene ligand was deduced from the results obtained by single‐crystal X‐ray diffraction analyses, spectroscopy, magnetometry, and Density Functional Theory (DFT) calculations. In the 1H NMR spectrum of the diamagnetic Y complex 1, the equivalent proton resonance of the bridging benzene dianion ligand is drastically shifted to higher field in comparison to free benzene. This and the calculated highly positive Nucleus‐Independent Chemical Shift (NICS) values are attributed to the antiaromatic character of the benzene dianion ligand. The crucial role of the ancillary guanidinate ligand scaffold in stabilizing the planar benzene dianion conformation was also elucidated by DFT calculations. Remarkably, the planarity of the benzene dianion originates from the stabilization of the π‐type orbitals of the d‐manifold and compression through its strong electrostatic interaction with the two REIII sites.
Scalable, High‐Yield Monolayer MXene Preparation from Multilayer MXene for Many Applications
Authors: Shi Xiangxiang , Yu Zhen , Liu Zi , Cao Ningning , Zhu Lin , Liu Yuyan , Zhao Ke , Shi Ting , Yin Liang , Fan Zhimin 
Published: October 2024

AbstractMXene (Ti3C2Tx) is renowned for its exceptional conductivity and hydrophilicity; however, the low yield of monolayers hinders its industrial scalability. Herein, we present a strategy to substantially enhance the monolayer yield by disrupting the hydrogen‐bonding cage confinement of multilayer MXene using high‐temperature ultrasound, challenging the conventional belief that monolayer MXene can only be prepared at lower temperatures. At approximately 70 °C, the weakened hydrogen bonding between the oxygen‐containing terminal groups of multilayer MXene and surrounding water molecules weakens the hydrogen‐bond cage confinement. This enables ultrasonic cavitation to generate more microbubbles that penetrate the interlayers of multilayer MXene, resulting in gentle and thorough delamination into larger monolayer nanosheets. Achieving up to a 95 % yield in just tens of minutes, these nanosheets exhibit properties comparable to those produced by traditional ice‐bath methods. Furthermore, the high‐concentration MXene ink produced on a large scale using this high‐yield approach exhibits excellent printing and processing capabilities, and the corresponding products showcase superior infrared stealth and Joule heating characteristics. This work addresses a key technical bottleneck in MXene production, paving the way for its extensive technological and industrial applications.
Localized Oxidative Catalytic Reactions Triggered by Cavitation Bubbles Confinement on Copper Oxide Microstructured Particles.
Authors: Mahendran Valarmathi , Trinh Quang Thang , Zhangyue Xie , Jonnalagadda Umesh , Gould Tim , Nguyen Nam‐Trung , Kwan James , Choksi Tej S. , Liu Wen , Valange Sabine , Jérôme François , Amaniampong Prince Nana 
Published: October 2024

AbstractEfficient energy transfer management in catalytic processes is crucial for overcoming activation energy barriers while minimizing costs and CO2 emissions. We exploit here a concept of CuO particle design with multiple gas‐stabilizing sites, engineered to function as cavitation nuclei and catalysts. This concept facilitates the selective and efficient acoustic energy transfer directly to the catalyst surface, avoiding the undesired dissipation of acoustic energy into the bulk solution while demonstrating superior cavitation properties at lower acoustic pressure amplitudes. Utilizing a chemical thermometric approach, we demonstrate that the local temperature on the surface of our CuO particles during cavitation bubble implosions can create an effective equivalent temperature of about 360 °C. This temperature effect facilitates the efficient catalysis of oxidative reactions using an organic pollutant probe molecule. Density functional theory (DFT) calculations were used to assess the decomposition of H2O2 and of pollutant probe molecule on CuO (111). Our work represents a significant advance in sonocatalytic systems, promising efficient energy use in catalytic reactions.
Exploring elbow kinematics in the central bearded dragon (Pogona vitticeps) using XROMM: Implications for the role of forearm long‐axis rotation in non‐avian reptile posture and mobility
Authors: Bonnan Matthew F. , Crisp Lexi Moore , Barton Ashley , Dizinno Jenna , Muller Kelly , Smith Justine , Walker Jenna 
Published: October 2024

AbstractThe functional morphology and kinematics of the elbow joint remain relatively understudied in squamates. Previous investigations of lizard elbow morphology and kinematics suggest long‐axis rotation (LAR) of the radius and ulna during stance allows the manus to remain pronated during forelimb retraction. Using XROMM (X‐ray Reconstruction of Moving Morphology), we explored the range of 3D movements and kinematics of the humerus, radius, and ulna in three adult male Central bearded dragons (Pogona vitticeps) during trackway walking. Our data indicate that the elbow joint of P. vitticeps experiences significant rotations in all three dimensions and that the radius and ulna adduct and rotate laterally on their long axes relative to the elbow joint and to one another during stance. These movements allow the distal ends of the radius and ulna to remain in a configuration necessary for manus pronation. These data support previous inferences that the radius and ulna of lizards move independently at the wrist joint. We suggest that independent LAR of the radius and ulna relative to the elbow joint and to one another may be an ancestral mechanism in lizards and perhaps more broadly across non‐avian reptiles.
An Improved Gold(I) Catalytic System for the Preparation of Coumarins via Intramolecular Cyclization
Authors: Ravera Francesco , Floreani Federico , Tubaro Cristina , Roverso Marco , Pedrazzani Riccardo , Bandini Marco , Biffis Andrea 
Published: October 2024

AbstractA catalytic system comprising a gold(I) complex with an N‐heterocyclic carbene (NHC) ligand in an ionic liquid as solvent exhibits higher catalytic efficiency compared to state of the art systems in the title reaction, which enables using down to 0.01 mol % gold. A commercial gold(I) catalyst such as IPrAuNTf2 can be employed for this purpose. In the case of less reactive substrates bearing electron‐withdrawing substituents at the phenol moiety, a tailor made NHC‐gold(I) precatalyst exhibits improved reactivity and can be advantageously employed compared to the commercial one.
Robust fixed‐time cooperative control for nonlinear multi‐agent systems via event‐triggered communication
Authors: Zhang Jierui , Zhang Weilun , Xia Hongwei , Ma Guangcheng 
Published: October 2024

AbstractThis article presents a robust fixed‐time cooperative control scheme for high‐order nonlinear multi‐agent systems under event‐triggered communication. A fixed‐time leader‐states estimator with event‐triggered communication is first designed to reconstruct the essential information, since only a fraction of agents can access the leader. Subsequently, we develop a disturbance observer‐based fixed‐time dynamic surface controller that utilizes the estimated leader state. The fixed‐time convergence of the whole closed‐loop system is proved by Lyapunov stability theory. Finally, numerical simulations elucidate the validity of the theoretical result.