bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supernova remnants dynamics
Authors: Decourchelle Anne 
Published: October 2017

AbstractSupernova remnants are the site of a number of physical processes (shock-heating, non-equilibrium ionization, hydrodynamic instabilities, particle acceleration, magnetic field amplification). Their related emission processes provide us with a large set of observational data. Supernova remnants result from the interaction of high-velocity material ejected by the supernova explosion with the medium surrounding the progenitor star. This interaction gives rise to a double-shock structure that lasts for hundreds of years, with a forward shock and a reverse shock compressing and heating to tens million of degrees the surrounding medium and the ejecta, respectively. It is mostly in this phase that young supernova remnants provide information on their explosion mechanism through spectro-imaging observations of the ejected nucleosynthesis products and their dynamics, notably in the X-ray domain. I will review these observations and their implications for our current understanding of the dynamics of supernova remnants. I will conclude on the prospects with future facilities.
The Rights of Future Generations within the Post-Paris Climate Regime
Authors: Lewis Bridget 
Published: October 2017

AbstractIn recognition of the intrinsic links between climate change and human rights, many have argued that human rights should play a leading role in guiding state responses to climate change. A group whose human rights will inevitably be affected by climate action (or inaction) today are the members of future generations. Yet, despite their particular vulnerability, future generations so far have gone largely unnoticed in human rights analyses. An adequate response to climate change requires that we recognize and address the human rights consequences for future generations, and consider the legal, practical and theoretical questions involved. This article attempts to answer these questions with a particular focus on the Paris Agreement. It argues that the recognition of state obligations towards future generations is compatible with human rights theory, and that these obligations must be balanced against the duties owed to current generations. The article concludes with a number of suggestions for how this balance could be pursued.
The Impact of Intergroup Helping on Third Parties’ Perceptions	of Group Reputation
Authors: Täuber Susanne , van Leeuwen Esther 
Published: October 2017

Abstract. We investigated the consequences of intergroup helping for both the offering and the receiving group’s reputation in the eyes of third parties. In two experiments (N = 116 and N = 78), observers were presented with a group that offered versus requested help. Observers’ status beliefs confirmed the emergence of a status hierarchy that favored the group that offered help. Study 2 demonstrated that the newly emerged status differential quickly solidified. In particular, observers judged the help-offering group as more attractive and allocated more resources to this group. Consistent with the social structural hypothesis on stereotype content, attributions of competence were more relevant for groups’ reputation than attributions of warmth. We discuss the implications of our findings for societies comprising diverse groups.
Experimental measurement-device-independent quantum digital signatures
Authors: Roberts G. L. , Lucamarini M. , Yuan Z. L. , Dynes J. F. , Comandar L. C. , Sharpe A. W. , Shields A. J. , Curty M. , Puthoor I. V. , Andersson E. 
Published: October 2017

AbstractThe development of quantum networks will be paramount towards practical and secure telecommunications. These networks will need to sign and distribute information between many parties with information-theoretic security, requiring both quantum digital signatures (QDS) and quantum key distribution (QKD). Here, we introduce and experimentally realise a quantum network architecture, where the nodes are fully connected using a minimum amount of physical links. The central node of the network can act either as a totally untrusted relay, connecting the end users via the recently introduced measurement-device-independent (MDI)-QKD, or as a trusted recipient directly communicating with the end users via QKD. Using this network, we perform a proof-of-principle demonstration of QDS mediated by MDI-QKD. For that, we devised an efficient protocol to distil multiple signatures from the same block of data, thus reducing the statistical fluctuations in the sample and greatly enhancing the final QDS rate in the finite-size scenario.
The effect of giant lateral collapses on magma pathways and the location of volcanism
Authors: Maccaferri Francesco , Richter Nicole , Walter Thomas R. 
Published: October 2017

AbstractFlank instability and lateral collapse are recurrent processes during the structural evolution of volcanic edifices, and they affect and are affected by magmatic activity. It is known that dyke intrusions have the potential to destabilise the flanks of a volcano, and that lateral collapses may change the style of volcanism and the arrangement of shallow dykes. However, the effect of a large lateral collapse on the location of a new eruptive centre remains unclear. Here, we use a numerical approach to simulate the pathways of magmatic intrusions underneath the volcanic edifice, after the stress redistribution resulting from a large lateral collapse. Our simulations are quantitatively validated against the observations at Fogo volcano, Cabo Verde. The results reveal that a lateral collapse can trigger a significant deflection of deep magma pathways in the crust, favouring the formation of a new eruptive centre within the collapse embayment. Our results have implications for the long-term evolution of intraplate volcanic ocean islands.
Direct benefits explain interspecific variation in helping behaviour among cooperatively breeding birds
Authors: Kingma Sjouke A. 
Published: October 2017

AbstractKin selection theory provides one important explanation for seemingly altruistic helping behaviour by non-breeding subordinates in cooperative breeding animals. However, it cannot explain why helpers in many species provide energetically costly care to unrelated offspring. Here, I use comparative analyses to show that direct fitness benefits of helping others, associated with future opportunities to breed in the resident territory, are responsible for the widespread variation in helping effort (offspring food provisioning) and kin discrimination across cooperatively breeding birds. In species where prospects of territory inheritance are larger, subordinates provide more help, and, unlike subordinates that cannot inherit a territory, do not preferentially direct care towards related offspring. Thus, while kin selection can underlie helping behaviour in some species, direct benefits are much more important than currently recognised and explain why unrelated individuals provide substantial help in many bird species.
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
Authors: Smith Matthew J. , Ottoni Elizabeth , Ishiyama Noboru , Goudreault Marilyn , Haman André , Meyer Claus , Tucholska Monika , Gasmi-Seabrook Genevieve , Menezes Serena , Laister Rob C. , Minden Mark D. , Marschalek Rolf , Gingras Anne-Claude , Hoang Trang , Ikura Mitsuhiko 
Published: October 2017

AbstractElucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing the epigenetic regulator to a cytoplasmic RAS effector, AF6/afadin. We show here that AF6 employs a non-canonical, evolutionarily conserved α-helix to bind RAS, unique to AF6 and the classical RASSF effectors. Further, all patients with MLL-AF6 translocations express fusion proteins missing only this helix from AF6, resulting in exposure of hydrophobic residues that induce dimerization. We provide evidence that oligomerization is the dominant mechanism driving oncogenesis from rare MLL translocation partners and employ our mechanistic understanding of MLL-AF6 to examine how dimers induce leukemia. Proteomic data resolve association of dimerized MLL with gene expression modulators, and inhibiting dimerization disrupts formation of these complexes while completely abrogating leukemogenesis in mice. Oncogenic gene translocations are thus selected under pressure from protein structure/function, underscoring the complex nature of chromosomal rearrangements.
Novel anammox bacteria and nitrogen loss from Lake Superior
Authors: Crowe Sean A. , Treusch Alexander H. , Forth Michael , Li Jiying , Magen Cedric , Canfield Donald E. , Thamdrup Bo , Katsev Sergei 
Published: October 2017

AbstractAnaerobic ammonium oxidizing (anammox) bacteria own a central position in the global N-cycle, as they have the ability to oxidize NH4+ to N2 under anoxic conditions using NO2−. They are responsible for up to 50% of all N2 released from marine ecosystems into the atmosphere and are thus indispensible for balancing the activity of N-fixing bacteria and completing the marine N-cycle. The contribution, diversity, and impact of anammox bacteria in freshwater ecosystems, however, is largely unknown, confounding assessments of their role in the global N-cycle. Here we report the activity and diversity of anammox bacteria in the world’s largest freshwater lake—Lake Superior. We found that anammox performed by previously undiscovered bacteria is an important contributor to sediment N2 production. We observed striking differences in the anammox bacterial populations found at different locations within Lake Superior and those described from other locations. Our data thus reveal that novel anammox bacteria underpin N-loss from Lake Superior, and if more broadly distributed across inland waters would play an important role in continental N-cycling and mitigation of fixed nitrogen transfer from land to the sea.
Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China
Authors: Wang Liwei , Li Mei , Xie Jiangan , Cao Yuying , Liu Hongfang , He Yongqun 
Published: October 2017

AbstractWith increased usage of cardiovascular drugs (CVDs) for treating cardiovascular diseases, it is important to analyze CVD-associated adverse events (AEs). In this study, we systematically collected package insert-reported AEs associated with CVDs used in China, and developed and analyzed an Ontology of Cardiovascular Drug AEs (OCVDAE). Extending the Ontology of AEs (OAE) and NDF-RT, OCVDAE includes 194 CVDs, CVD ingredients, mechanisms of actions (MoAs), and CVD-associated 736 AEs. An AE-specific drug class effect is defined to exist when all the drugs (drug chemical ingredients or drug products) in a drug class are associated with an AE, which is formulated as a new proportional class level ratio (“PCR”) = 1. Our PCR-based heatmap analysis identified many class level drug effects on different AE classes such as behavioral and neurological AE and digestive system AE. Additional drug-AE correlation tests (i.e., class-level PRR, Chi-squared, and minimal case reports) were also modified and applied to further detect statistically significant drug class effects. Two drug ingredient classes and three CVD MoA classes were found to have statistically significant class effects on 13 AEs. For example, the CVD Active Transporter Interactions class (including reserpine, indapamide, digoxin, and deslanoside) has statistically significant class effect on anorexia and diarrhea AEs.
Bone Marrow Mononuclear Cells Combined with Beta-Tricalcium Phosphate Granules for Alveolar Cleft Repair: A 12-Month Clinical Study
Authors: Du Fengzhou , Wu Huanhuan , Li Haidong , Cai Lei , Wang Qian , Liu Xia , Xiao Ran , Yin Ningbei , Cao Yilin 
Published: October 2017

AbstractAlveolar cleft is the most common congenital bone defect. Autologous iliac crest bone graft (ICBG) is the most widely adopted procedure for alveolar cleft repair, but the condition is associated with door-site morbidities. For the first time, this study used bone marrow mononuclear cells (BMMNCs) combined with beta-tricalcium phosphate (β-TCP) granules to repair alveolar bone defect. The effectiveness of this technique was compared with autologous ICBG after 12 months of follow-up. The bone formation volume was quantitatively evaluated by three-dimensional computed tomography and computer aided engineering technology. BMMNCs/β-TCP granule grafting was radiographically equivalent to ICBG in alveolar cleft repair. Although considerable resorption was observed up to 6 months after surgery, no significant differences were noted in the Chelsea score and bone formation volume between groups. These finding indicate that BMMNCs/β-TCP grafting is a safe and effective approach for alveolar bone regeneration.
Site-selective spectroscopy with depth resolution using resonant x-ray reflectometry
Authors: Hamann-Borrero J. E. , Macke S. , Gray B. , Kareev M. , Schierle E. , Partzsch S. , Zwiebler M. , Treske U. , Koitzsch A. , Büchner B. , Freeland J. W. , Chakhalian J. , Geck J. 
Published: October 2017

AbstractCombining dissimilar transition metal oxides (TMOs) into artificial heterostructures enables to create electronic interface systems with new electronic properties that do not exist in bulk. A detailed understanding of how such interfaces can be used to tailor physical properties requires characterization techniques capable to yield interface sensitive spectroscopic information with monolayer resolution. In this regard resonant x-ray reflectivity (RXR) provides a unique experimental tool to achieve exactly this. It yields the element specific electronic depth profiles in a non-destructive manner. Here, using a YBa2Cu3O7−δ
(YBCO) thin film, we demonstrate that RXR is further capable to deliver site selectivity. By applying a new analysis scheme to RXR, which takes the atomic structure of the material into account, together with information of the local charge anisotropy of the resonant ions, we obtained spectroscopic information from the different Cu sites (e.g., chain and plane) throughout the film profile. While most of the film behaves bulk-like, we observe that the Cu-chains at the surface show characteristics of electron doping, whereas the Cu-planes closest to the surface exhibit an orbital reconstruction similar to that observed at La1−x
Ca
x
MnO3/YBCO interfaces.
Quantum size effect on charges and phonons ultrafast dynamics in atomically controlled nanolayers of topological insulators Bi2Te3
Authors: Weis M. , Wilk B. , Vaudel G. , Balin K. , Rapacz R. , Bulou A. , Arnaud B. , Szade J. , Ruello P. 
Published: October 2017

AbstractHeralded as one of the key elements for next generation spintronics devices, topological insulators (TIs) are now step by step envisioned as nanodevices like charge-to-spin current conversion or as Dirac fermions based nanometer Schottky diode for example. However, reduced to few nanometers, TIs layers exhibit a profound modification of the electronic structure and the consequence of this quantum size effect on the fundamental carriers and phonons ultrafast dynamics has been poorly investigated so far. Here, thanks to a complete study of a set of high quality molecular beam epitaxy grown nanolayers, we report the existence of a critical thickness of around ~6 nm, below which a spectacular reduction of the carrier relaxation time by a factor of ten is found in comparison to bulk Bi2 Te3 In addition, we also evidence an A1g optical phonon mode softening together with the appearance of a thickness dependence of the photoinduced coherent acoustic phonons signals. This drastic evolution of the carriers and phonons dynamics might be due an important electron-phonon coupling evolution due to the quantum confinement. These properties have to be taken into account for future TIs-based spintronic devices.
Genomics of extreme ecological specialists: multiple convergent evolution but no genetic divergence between ecotypes of Maculinea alcon butterflies
Authors: Koubínová Darina , Dincă Vlad , Dapporto Leonardo , Vodă Raluca , Suchan Tomasz , Vila Roger , Alvarez Nadir 
Published: October 2017

AbstractBiotic interactions are often acknowledged as catalysers of genetic divergence and eventual explanation of processes driving species richness. We address the question, whether extreme ecological specialization is always associated with lineage sorting, by analysing polymorphisms in morphologically similar ecotypes of the myrmecophilous butterfly Maculinea alcon. The ecotypes occur in either hygric or xeric habitats, use different larval host plants and ant species, but no significant distinctive molecular traits have been revealed so far. We apply genome-wide RAD-sequencing to specimens originating from both habitats across Europe in order to get a view of the potential evolutionary processes at work. Our results confirm that genetic variation is mainly structured geographically but not ecologically — specimens from close localities are more related to each other than populations of each ecotype from distant localities. However, we found two loci for which the association with xeric versus hygric habitats is supported by segregating alleles, suggesting convergent evolution of habitat preference. Thus, ecological divergence between the forms probably does not represent an early stage of speciation, but may result from independent recurring adaptations involving few genes. We discuss the implications of these results for conservation and suggest preserving biotic interactions and main genetic clusters.
Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
Authors: Schweiger Susann , Matthes Frank , Posey Karen , Kickstein Eva , Weber Stephanie , Hettich Moritz M. , Pfurtscheller Sandra , Ehninger Dan , Schneider Rainer , Krauß Sybille 
Published: October 2017

AbstractThe formation of paired helical filaments (PHF), which are composed of hyperphosphorylated Tau protein dissociating from microtubules, is one of the pathological hallmarks of Alzheimer’s disease (AD) and other tauopathies. The most important phosphatase that is capable of dephosphorylating Tau at AD specific phospho-sites is protein phosphatase 2 A (PP2A). Here we show that resveratrol, a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-dependent epitopes. The increase in PP2A activity is caused by decreased expression of the MID1 ubiquitin ligase that mediates ubiquitin-specific modification and degradation of the catalytic subunit of PP2A when bound to microtubules. Interestingly, we further show that MID1 expression is elevated in AD tissue. Our data suggest a key role of MID1 in the pathology of AD and related tauopathies. Together with previous studies showing that resveratrol reduces β-amyloid toxicity they also give evidence of a promising role for resveratrol in the prophylaxis and therapy of AD.
One-step growth of multilayer-graphene hollow nanospheres via the self-elimination of SiC nuclei templates
Authors: Kim Byeong Geun , Nam Deok-Hui , Jeong Seong-Min , Lee Myung-Hyun , Seo Won-Seon , Choi Soon-Mok 
Published: October 2017

AbstractWe introduce a one-step growth method for producing multilayer-graphene hollow nanospheres via a high-temperature chemical vapor deposition process using tetramethylsilane as an organic precursor. When the SiC nuclei were grown under an excess carbon atmosphere, they were surrounded via desorption of the hydrocarbon gas species, and graphene layers formed on the surface of the SiC nuclei via the rearrangement of solid carbon during the heating and cooling. The core SiC nuclei were spontaneously removed by the subsequent thermal decomposition, which also supplied the carbon for the graphene layers. Hence, multilayer-graphene hollow nanospheres were acquired via a one-step process, which was simply controlled by the growth temperature. In this growth process, the SiC nuclei acted as both the template and carbon source for the formation of multilayer-graphene hollow nanospheres.
Live cell X-ray imaging of autophagic vacuoles formation and chromatin dynamics in fission yeast
Authors: Strelnikova Natalja , Sauter Nora , Guizar-Sicairos Manuel , Göllner Michael , Diaz Ana , Delivani Petrina , Chacón Mariola , Tolić Iva M. , Zaburdaev Vasily , Pfohl Thomas 
Published: October 2017

AbstractSeeing physiological processes at the nanoscale in living organisms without labeling is an ultimate goal in life sciences. Using X-ray ptychography, we explored in situ the dynamics of unstained, living fission yeast Schizosaccharomyces pombe cells in natural, aqueous environment at the nanoscale. In contrast to previous X-ray imaging studies on biological matter, in this work the eukaryotic cells were alive even after several ptychographic X-ray scans, which allowed us to visualize the chromatin motion as well as the autophagic cell death induced by the ionizing radiation. The accumulated radiation of the sequential scans allowed for the determination of a characteristic dose of autophagic vacuole formation and the lethal dose for fission yeast. The presented results demonstrate a practical method that opens another way of looking at living biological specimens and processes in a time-resolved label-free setting.
Genetic Characterization of Chinese fir from Six Provinces in Southern China and Construction of a Core Collection
Authors: Duan Hongjing , Cao Sen , Zheng Huiquan , Hu Dehuo , Lin Jun , Cui Binbin , Lin Huazhong , Hu Ruiyang , Wu Bo , Sun Yuhan , Li Yun 
Published: October 2017

AbstractLarge ex situ germplasm collections of plants generally contain significant diversity. A set of 700 well-conserved Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) clones from six provinces in southern China in the ex situ gene bank of Longshan State Forest, was analyzed using 21 simple sequence repeat markers, with the aim of assessing the genetic diversity of these germplasm resources. Genetic analysis revealed extensive genetic variation among the accessions, with an average of 8.31 alleles per locus and a mean Shannon index of 1.331. Excluding loci with null alleles, we obtained a low level of genetic differentiation among provinces, consistent with the interpopulation genetic variation (1%). Three clusters were identified by STRUCTURE, which did not match the individuals’ geographical provenances. Ten traits related to growth and wood properties were quantified in these individuals, and there was substantial variation in all traits across individuals, these provide a potential source of variation for genetic improvement of the Chinese fir. Screening large collections for multiple-trait selective breeding programs is laborious and expensive; a core collection of 300 accessions, representative of the germplasm, was established, based on genotypic and phenotypic data. The identified small, but diverse, collections will be useful for further genome-wide association studies.