bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High-Performing Sulfur-Tolerant and Redox-Stable Layered Perovskite Anode for Direct Hydrocarbon Solid Oxide Fuel Cells
Authors: Ding Hanping , Tao Zetian , Liu Shun , Zhang Jiujun 
Published: December 2015

AbstractDevelopment of alternative ceramic oxide anode materials is a key step for direct hydrocarbon solid oxide fuel cells (SOFCs). Several lanthanide based layered perovskite-structured oxides demonstrate outstanding oxygen diffusion rate, favorable electronic conductivity and good oxygen surface exchange kinetics, owing to A-site ordered structure in which lanthanide and alkali-earth ions occupy alternate (001) layers and oxygen vacancies are mainly located in [LnOx] planes. Here we report a nickel-free cation deficient layered perovskite, (PrBa)0.95(Fe0.9Mo0.1)2O5 + δ (PBFM), for SOFC anode and this anode shows an outstanding performance with high resistance against both carbon build-up and sulfur poisoning in hydrocarbon fuels. At 800 °C, the layered PBFM showed high electrical conductivity of 59.2 S cm−1 in 5% H2 and peak power densities of 1.72 and 0.54 W cm−2 using H2 and CH4 as fuel, respectively. The cell exhibits a very stable performance under a constant current load of 1.0 A cm−2. To our best knowledge, this is the highest performance of ceramic anodes operated in methane. In addition, the anode is structurally stable at various fuel and temperature conditions, suggesting that it is a feasible material candidate for high-performing SOFC anode.
Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis
Authors: Lee Juneyoung , Park Eun Jeong , Yuki Yoshikazu , Ahmad Shandar , Mizuguchi Kenji , Ishii Ken J. , Shimaoka Motomu , Kiyono Hiroshi 
Published: December 2015

AbstractInflammatory bowel diseases (IBDs) accompany a critical loss of the frontline barrier function that is achieved primarily by intestinal epithelial cells (IECs). Although the gene-regulation pathways underlying these host-defense roles of IECs presumably are deranged during IBD pathogenesis, the quantitative and qualitative alterations of posttranscriptional regulators such as microRNAs (miRNAs) within the cells largely remain to be defined. We aimed to uncover the regulatory miRNA–target gene relationships that arise differentially in inflamed small- compared with large-IECs. Whereas IBD significantly increased the expression of only a few miRNA candidates in small-IECs, numerous miRNAs were upregulated in inflamed large-IECs. These marked alterations might explain why the large, as compared with small, intestine is more sensitive to colitis and shows more severe pathology in this experimental model of IBD. Our in-depth assessment of the miRNA–mRNA expression profiles and the resulting networks prompts us to suggest that miRNAs such as miR-1224, miR-3473a and miR-5128 represent biomarkers that appear in large-IECs upon IBD development and co-operatively repress the expression of key anti-inflammatory factors. The current study provides insight into gene-regulatory networks in IECs through which dynamic rearrangement of the involved miRNAs modulates the gene expression–regulation machinery between maintaining and disrupting gastrointestinal homeostasis.
Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids
Authors: Bakkaiova Jana , Marini Victoria , Willcox Smaranda , Nosek Jozef , Griffith Jack D. , Krejci Lumir , Tomaska Lubomir 
Published: December 2015

Yeast mtDNA is compacted into nucleoprotein structures called mitochondrial nucleoids (mt-nucleoids). The principal mediators of nucleoid formation are mitochondrial high-mobility group (HMG)-box containing (mtHMG) proteins. Although these proteins are some of the fastest evolving components of mt-nucleoids, it is not known whether the divergence of mtHMG proteins on the level of their amino acid sequences is accompanied by diversification of their biochemical properties. In the present study we performed a comparative biochemical analysis of yeast mtHMG proteins from Saccharomyces cerevisiae (ScAbf2p), Yarrowia lipolytica (YlMhb1p) and Candida parapsilosis (CpGcf1p). We found that all three proteins exhibit relatively weak binding to intact dsDNA. In fact, ScAbf2p and YlMhb1p bind quantitatively to this substrate only at very high protein to DNA ratios and CpGcf1p shows only negligible binding to dsDNA. In contrast, the proteins exhibit much higher preference for recombination intermediates such as Holliday junctions (HJ) and replication forks (RF). Therefore, we hypothesize that the roles of the yeast mtHMG proteins in maintenance and compaction of mtDNA in vivo are in large part mediated by their binding to recombination/replication intermediates. We also speculate that the distinct biochemical properties of CpGcf1p may represent one of the prerequisites for frequent evolutionary tinkering with the form of the mitochondrial genome in the CTG-clade of hemiascomycetous yeast species.
Vertebral Artery Injury during Routine Posterior Cervical Exposure: Case Reports and Review of Literature
Authors: Molinari Robert W. , Chimenti Peter C. , Molinari Robert , Gruhn William 
Published: December 2015

Study Design Case series. Objective We report the unusual occurrence of vertebral artery injury (VAI) during routine posterior exposure of the cervical spine. The importance of preoperative planning to identify the course of the bilateral vertebral arteries during routine posterior cervical spine surgery is emphasized. Methods VAI is a rare but potentially devastating complication of cervical spinal surgery. Most reports of VAI are related to anterior surgical exposure or screw placement in the posterior cervical spine. VAI incurred during posterior cervical spinal exposure surgery is not adequately addressed in the existing literature. Two cases of VAI that occurred during routine posterior exposure of the cervical spine in the region of C2 are described. Results VAI was incurred unexpectedly in the region of the midportion of the posterior C1–C2 interval during the initial surgical exposure phase of the operation. An aberrant vertebral artery course in the V2 anatomical section in the region between C1 and C2 intervals was identified postoperatively in both patients. A literature review demonstrates a relatively high incidence of vertebral artery anomalies in the upper cervical spine; however, the literature is deficient in reporting vertebral artery injury in this region. Recommendations for preoperative vertebral artery imaging also remain unclear at this time. Conclusions Successful management of this unexpected complication was achieved in both cases. This case report and review of the literature highlights the importance of preoperative vertebral artery imaging and knowledge of the course of the vertebral arteries prior to planned routine posterior exposure of the upper cervical spine. In both cases, aberrancy of the vertebral artery was present and not investigated or detected preoperatively.
Is Hydronephrosis a Complication after Anterior Lumbar Surgery?
Authors: Parks Ruth M. , Behrbalk Eyal , Mosharraf Syed , Müller Roger M. , Boszczyk Bronek M. 
Published: December 2015

Study Design Prospective follow-up design. Objective Ureteral injury is a recognized complication following gynecologic surgery and can result in hydronephrosis. Anterior lumbar surgery includes procedures like anterior lumbar interbody fusion (ALIF) and total disk replacement (TDR). Anterior approaches to the spine require mobilization of the great vessels and visceral organs. The vascular supply to the ureter arising from the iliac arteries may be compromised during midline retraction of the ureter, which could theoretically lead to ureter ischemia and stricture with subsequent hydronephrosis formation. Methods Potential candidates with previous ALIF or TDR via anterior retroperitoneal access between January 2008 and March 2012 were chosen from those operated on by a single surgeon in a university hospital setting ( n = 85). Renal ultrasound evaluation of hydronephrosis was performed on all participants. Simple descriptive and inferential statistics were used to generate results. Results A total of 37 voluntary participants were recruited (23 male, 14 female subjects; average age 51.8 years). The prevalence of hydronephrosis in our population was 0.0% (95% confidence interval 0 to 8.1%). Conclusions Retraction of the ureter across the midline in ALIF and TDR does not result in an increase in hydronephrosis and appears to be a safe surgical technique.
Comparison of Silicate-Substituted Calcium Phosphate (Actifuse) with Recombinant Human Bone Morphogenetic Protein-2 (Infuse) in Posterolateral Instrumented Lumbar Fusion
Authors: Licina Paul , Coughlan Marc , Johnston Emma , Pearcy Mark 
Published: December 2015

Study Design Randomized controlled trial. Objective The aim of this study was to assess the efficacy of the bone grafting substitute silicate-substituted calcium phosphate (SiCaP) compared with recombinant human bone morphogenetic protein 2 (rhBMP-2) and to evaluate the clinical outcomes over a period of 2 years. Methods Patients undergoing PLF surgery for DDD at a single center were recruited and randomized to one of two groups: SiCaP ( n = 9) or rhBMP-2 ( n = 10). One patient withdrew prior to randomization and another from the rhBMP-2 group after randomization. The radiologic and clinical outcomes were examined and compared. Fusion was assessed at 12 months with computed tomography and plain radiographs. Clinical outcomes were evaluated by recording measures of pain, quality of life, disability, and neurologic status from 6 weeks to 2 years postoperatively. Results In the SiCaP and rhBMP-2 groups, fusion was observed in 9/9 and 8/9 patients, respectively. Pain and disability scores were reduced and quality of life increased in both groups. Leg pain, disability, and satisfaction scores were similar between the groups at each postoperative point; however, back pain was less at 6 weeks and quality of life was higher at 6 months in the SiCaP group than the rhBMP-2 group. Conclusions SiCaP and rhBMP-2 were comparable in terms of achieving successful bone growth and fusion. Both groups achieved similar alleviation of pain and improved quality of life and neurologic, satisfaction, and return to work outcomes following PLF surgery.
Nonoperative Management of Craniocervical Ligamentous Distraction Injury: Literature Review
Authors: Kaplan Nathan B. , Molinari Christine , Molinari Robert W. 
Published: December 2015

Study Design Literature review and case report. Objective Review the existing literature and report the successful nonoperative management of a two-level craniocervical ligamentous distraction injury. Methods A PubMed and Medline review revealed only three limited reports involving the nonoperative management of patients with craniocervical distraction injury. This article reviews the existing literature and reports the case of a 27-year-old man who was involved in a motorcycle accident and sustained multiple systemic injuries and ligamentous distraction injuries to both occipitocervical joints and both C1–C2 joints. The patient's traumatic brain injury and bilateral pulmonary contusions precluded safe operative management of the two-level craniocervical distraction injury. Therefore, the patient was placed in a halo immobilization device. Results The literature remains unclear as to the specific indications for nonoperative management of ligamentous craniocervical injuries. Nonoperative management was associated with poor outcomes in the majority of reported patients. We report a patient who was managed for 6 months in a halo device. Posttreatment computed tomography and flexion–extension radiographs demonstrated stable occipitocervical and C1–C2 joints bilaterally. The patient reported minimal neck pain and had excellent functional outcome with a Neck Disability Index score of 2 points at 41 months postoperatively. He returned to preinjury level of employment without restriction. Conclusions Further study is needed to determine which craniocervical injuries may be managed successfully with nonoperative measures.
Article Commentary: The Practical Application of Clinical Prediction Rules: A Commentary Using Case Examples in Surgical Patients with Degenerative Cervical Myelopathy
Authors: Tetreault Lindsay , Le David , C⊚té Pierre , Fehlings Michael 
Published: December 2015

Study Design Commentary. Objective This commentary aims to discuss the practical applications of a clinical prediction rule (CPR) developed to predict functional status in patients undergoing surgery for the treatment of degenerative cervical myelopathy. Methods Clinical cases from the AOSpine CSM-North America study were used to illustrate the application of a prediction rule in a surgical setting and to highlight how this CPR can be used to ultimately enhance patient care. Results A CPR combines signs and symptoms, patient characteristics, and other predictive factors to estimate disease probability, treatment prognosis, or risk of complications. These tools can influence allocation of health care resources, inform clinical decision making, and guide the design of future research studies. In a surgical setting, CPRs can be used to (1) manage patients’ expectations of outcome and, in turn, improve overall satisfaction; (2) facilitate shared decision making between patient and physician; (3) identify strategies to optimize surgical results; and (4) reduce heterogeneity of care and align surgeons’ perceptions of outcome with objective evidence. Conclusions Valid and clinically-relevant CPRs have tremendous value in a surgical setting.
Remote Cerebellar Hemorrhage after Revision Lumbar Spine Surgery
Authors: Haller Justin M. , Calvert Graham , Spiker William R. , Brodke Darrel S. , Lawrence Brandon D. 
Published: December 2015

Study Design Case report. Objective To report a case of remote cerebellar hemorrhage (RCH) without intraoperative dural tear after revision lumbar spine surgery. RCH is a rare postoperative complication following spine surgery. RCH has previously been reported only in cases with intraoperative dural tear or durotomy. Methods Case report and literature review. Results A 58-year-old woman underwent removal of L4–S1 posterior spinal instrumented fusion (PSIF) implants and L3–L4 decompressive laminectomy with PSIF. There was no intraoperative dural tear. After doing well initially, the patient developed new neurologic symptoms and was found to have RCH. Lumbar spine magnetic resonance imaging (MRI) demonstrated a large dural defect. After repair of the dura, the patient had dramatic improvement of her neurologic symptoms. At 1-year follow-up, the patient continued to have no neurologic sequelae. Conclusion This report demonstrates that RCH can occur without intraoperative dural tear. Although rare, any patient with new onset of declining neurologic symptoms following spine surgery should have a brain MRI and should have RCH on the differential diagnosis.
Signatures and control of strong-field dynamics in a complex system
Authors: Meyer Kristina , Liu Zuoye , Müller Niklas , Mewes Jan-Michael , Dreuw Andreas , Buckup Tiago , Motzkus Marcus , Pfeifer Thomas 
Published: December 2015

Significance
Using intense lasers to control complex molecules is a long-held dream in science. In this article, we develop a physics concept for measuring and controlling the quantum states of complex molecules by strong laser fields. We show that, in particular, the quantum-mechanical phase of excited molecular states can be manipulated by the intense laser, a key quantity for full (amplitude and phase) control of molecular quantum states. With the help of time- and intensity-resolved absorption spectroscopy experiments, we apply this idea to the dynamics of a large dye molecule in solution. The demonstrated phase-control concept thus represents a major leap toward the ultimate goal of laser chemistry.
Eleventh-century shift in timber procurement areas for the great houses of Chaco Canyon
Authors: Guiterman Christopher H. , Swetnam Thomas W. , Dean Jeffrey S. 
Published: December 2015

Significance
The iconic great houses of Chaco Canyon occupy a nearly treeless landscape and yet were some of the largest pre-Columbian structures in North America. This incongruity has sparked persistent debate over the origins of more than 240,000 trees used in construction. We used tree-ring methods for determining timber origins for the first time to our knowledge in the southwestern United States and show that 70% of timbers likely originated over 75 km from Chaco. We found that a previously unrecognized timber source, the Zuni Mountains, supplied construction beams as early as the 850s in the Common Era. Further, we elucidate shifting dynamics of procurement that highlight the importance of a single landscape, the Chuska Mountains, in the florescence of the Chacoan system.
Omega-3 deficiency impairs honey bee learning
Authors: Arien Yael , Dag Arnon , Zarchin Shlomi , Masci Tania , Shafir Sharoni 
Published: December 2015

Significance
Omega-3 is an essential polyunsaturated fatty acid (PUFA) that most animals need to acquire in their diet. Mammalian brains are rich in docosahexaenoic acid (DHA), a long-chain form of omega-3, whose deficiency, coupled with a high omega-6:3 ratio, leads to numerous cognitive disorders and mental diseases. Insects have only trace amounts of long-chain PUFAs, and the effect of omega-3 deficiency on cognition has not been studied. We found that omega-3 deficiency greatly impaired honey bee learning, extending the finding of the importance of omega-3 to a nonmammal, despite lack of DHA in its brain. Furthermore, our analyses of pollens suggest that many managed colonies are experiencing a shift in available forage toward a higher omega-6:3 ratio, which may be leading to colony declines.
Constant mortality and fertility over age inHydra
Authors: Schaible Ralf , Scheuerlein Alexander , Dańko Maciej J. , Gampe Jutta , Martínez Daniel E. , Vaupel James W. 
Published: December 2015

SignificanceHow an organism changes with age and why the pattern of change differs across species are questions that have intrigued biologists since Aristotle. Patterns of change can be described by trajectories of birth and death rates over age. For humans and many other mammals, mortality increases and fertility declines with age among adults. For other species, however, a remarkable variety of patterns has been observed. Although roughly constant mortality and fertility trajectories have been reported for some species, the data are problematic because sample sizes are small, especially at older ages. Here, we present compelling evidence for constant mortality and reproduction ofHydrausing data from careful, large-scale studies over 8 y with 2,256 individuals.
Coordinated regulation of vegetative and reproductive branching in rice
Authors: Wang Lei , Sun Shengyuan , Jin Jiye , Fu Debao , Yang Xuefei , Weng Xiaoyu , Xu Caiguo , Li Xianghua , Xiao Jinghua , Zhang Qifa 
Published: December 2015

Significance
The patterns of lateral branching, including tillers and inflorescence branches, determine grain yields of many cereals. In this study, we characterized a regulatory network composed of microRNAs and transcription factor that coordinately regulate vegetative (tiller) and reproductive (panicle) branching in rice. The findings hold tremendous promise for application in rice genetic improvement and may also have general implications for understanding branching regulation of grasses.
Extending gene ontology with gene association networks
Authors: Peng Jiajie , Wang Tao , Wang Jixuan , Wang Yadong , Chen Jin 
Published: December 2015

Abstract
Motivation: Gene ontology (GO) is a widely used resource to describe the attributes for gene products. However, automatic GO maintenance remains to be difficult because of the complex logical reasoning and the need of biological knowledge that are not explicitly represented in the GO. The existing studies either construct whole GO based on network data or only infer the relations between existing GO terms. None is purposed to add new terms automatically to the existing GO.
Results: We proposed a new algorithm ‘GOExtender’ to efficiently identify all the connected gene pairs labeled by the same parent GO terms. GOExtender is used to predict new GO terms with biological network data, and connect them to the existing GO. Evaluation tests on biological process and cellular component categories of different GO releases showed that GOExtender can extend new GO terms automatically based on the biological network. Furthermore, we applied GOExtender to the recent release of GO and discovered new GO terms with strong support from literature.
Availability and implementation: Software and supplementary document are available at www.msu.edu/%7Ejinchen/GOExtender
Contact: jinchen@msu.edu or ydwang@hit.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
Program extraction applied to monadic parsing
Authors: Berger Ulrich , Jones Alison , Seisenberger Monika 
Published: December 2015

Abstract
This article outlines a proof-theoretic approach to developing correct and terminating monadic parsers. Using modified realizability, we extract formally verified and terminating programs from formal proofs. By extracting both primitive parsers and parser combinators, it is ensured that all complex parsers built from these are also correct, complete and terminating for any input. We demonstrate the viability of our approach by means of two case studies: we extract (i) a small arithmetic calculator and (ii) a non-deterministic natural language parser. The work is being carried out in the interactive proof system Minlog.