bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of Ceramic Production and Consumption on the Greek Mainland During the Middle Stages of the Late Bronze Age: The Waterpots from the Menelaion, Sparta
Authors: Lis Bartłomiej 
Published: July 2017

SummaryThe article examines pottery groups manufactured in non‐Mycenaean traditions from the site of the Menelaion in Laconia (southern Peloponnese, Greece) during the middle stages of the Late Bronze Age. Pottery traditions are first defined using macroscopic study of surface and break features. Two distinct handmade traditions, and another one employing the wheel but with some links to traditional handmade pottery manufactured on the island of Aegina, were recognized and subjected to petrographic analysis. Its results confirmed that potters’ choices regarding clay preparation were different in the case of each identified tradition, being most distinct for the largest group of handmade undecorated water jars. The study highlights survival of pottery traditions with roots in the Middle Helladic period well into the Late Bronze Age, a fact that has not received appropriate attention in the scholarly discourse. It captures the very last stage of their existence, as just a few decades later the production and consumption are entirely dominated by Mycenaean pottery.
Beyond Iron Age ‘towns’: Examining oppida as examples of low‐density urbanism
Authors: Moore Tom 
Published: July 2017

SummaryThe question of whether Late Iron Age oppida in Europe were truly ‘urban’ has dominated debate over these sites since the nineteenth century. Oppida have been surprisingly absent from comparative urban studies, however, despite increasingly nuanced perspectives on the nature and diversity of the urban phenomenon. In particular, Roland Fletcher's implication that oppida might represent part of a broader alternative form of low‐density urbanism has been largely overlooked, by Iron Age scholars and urbanism specialists alike. With the complex nature of many oppida now becoming increasingly apparent, I suggest it is a pertinent time to assess Fletcher's claim and examine whether oppida can be convincingly compared to low‐density urbanism elsewhere in the world and, if so, what implications this might have for understanding Iron Age societies. This paper argues that oppida do indeed display aspects of low‐density urbanism and that this is likely to be due to the negotiated nature of power in Iron Age societies.
Underweight and hypoalbuminemia as risk indicators for mortality among psychiatric patients with medical comorbidities
Authors: Haga Takahiro , Ito Kae , Ono Masahiro , Maruyama Jiro , Iguchi Mari , Suzuki Hitoe , Hayashi Eiji , Sakashita Kentaro , Nagao Tomoko , Ikemoto Shohei , Okaniwa Asuka , Kitami Makiko , Inuo Eriko , Tatsumi Koichiro 
Published: July 2017

AimMedical comorbidities are a major cause of death among patients with mental illness. The purpose of this study was to clarify the risk factors for mortality among psychiatric patients with medical comorbidities.MethodsWe retrospectively reviewed the clinical files of patients transferred to Tokyo Metropolitan Matsuzawa Hospital from a psychiatric hospital to treat medical comorbidities during the 3‐year period from January 2014 to December 2016. We analyzed the clinical differences between the expired and alive patients.ResultsOf the 287 patients included, 29 (10.1%) had expired at the time of hospital discharge, while 258 (89.9%) were living. A multivariable analysis to determine the prognostic factors related to mortality from medical comorbidities showed that body mass index <18.5 had the highest odds ratio among the predictive factors (5.1; 95% confidence interval, 1.5–17.1; P < 0.05), followed by a serum albumin level < 3.0 mg/dL (3.0; 95% confidence interval, 1.1–8.1; P < 0.05).ConclusionWe found that underweight and hypoalbuminemia were risk factors for mortality among psychiatric patients with medical comorbidities. Physicians at psychiatric hospitals should consider transferring patients with medical comorbidities to a general medical hospital in the presence of underweight and/or hypoalbuminemia.
Everolimus and reduced calcineurin inhibitor therapy in pediatric liver transplant recipients: Results from a multicenter, prospective study
Authors: Ganschow Rainer , Ericzon Bo‐Goran , Dhawan Anil , Sharif Khalid , Martzloff El‐Djouher , Rauer Barbara , Ng Jennifer , Lopez Patricia 
Published: July 2017

AbstractIn a 24‐month, multicenter, single‐arm, prospective study, 56 pediatric liver transplant patients with or without basiliximab induction were converted at 1‐6 months post‐transplant from standard calcineurin inhibitor (CN) therapy (± mycophenolic acid), to everolimus with reduced exposure to CNI (tacrolimus n=50, cyclosporine n=6). Steroid therapy was optional. Recruitment was stopped prematurely due to high rates of PTLD, treatment‐related serious infections leading to hospitalization and premature study drug discontinuation. Subsequently, patients aged <7 years reverted to local standard‐of‐care immunosuppression. Mean tacrolimus concentration was above or near the upper end of the maintenance target range (2‐5 ng/mL) until after month 6 post‐enrollment. The primary variable, mean (SD) change in eGFR from baseline to month 12 (last observation carried forward), was +6.2 (19.5) mL/min/1.73 m2. Two patients experienced treated biopsy‐proven acute rejection. No graft losses or deaths occurred. PTLD occurred in five patients (8.9%) (3/25 [12.0%] patients <2 years, 2/31 aged 2‐18 years [6.5%]). Adverse events, serious adverse events, and discontinuation due to adverse events were reported in 100.0%, 76.8%, and 44.6% of patients, respectively. In conclusion, everolimus with reduced CNI improved renal function while maintaining antirejection potency in pediatric liver transplant patients but safety outcomes suggest that patients were overimmunosuppressed.
Split liver transplantation for retroperitoneal immature teratoma masquerading as hepatoblastoma
Authors: Oh Dongkyu , Yi Nam‐Joon , Song Sanghee , Kim Ok Kyung , Hong Suk Kyun , Yoon Kyung Chul , Ahn Sung Woo , Kim Hyo‐Sin , Kim Hyeyoung , Kim Hyun‐Young , Kang Hyoung Jin , Lee Myungsu , Lee Kyoung Bun , Lee Kwang‐Woong , Suh Kyung Suk 
Published: July 2017

AbstractExtragonadal teratoma originating from the retroperitoneum represents less than 5% of all teratomas and accounts for less than 10% of all pediatric retroperitoneal neoplasms. To date, there has been no report of teratoma managed with LT. This study reports an infant aged 3 months with retroperitoneal immature teratoma involving the hepatic hilum, refractory to chemotherapy and treated with LT. The patient was referred to our hospital for management of a growing abdominal mass. Histopathology of a fine needle biopsy of the lesion suggested the possibility of a hepatoblastoma with teratoid features. Cisplatin‐based chemotherapy was initiated, but rapid growth of the tumor encasing the hepatic artery proper was detected, even after two cycles of chemotherapy. A split LT was carried out, and pathological examination of the explanted liver revealed the involvement of numerous neuroepithelial components, confirming the diagnosis of a Norris grade 3 immature teratoma. The patient recovered well and was discharged on day 19 post‐LT. As on date, on postoperative day 240, he has completed seven cycles of a 12‐cycle vinblastine and doxorubicin‐based adjuvant chemotherapy.
The Pinocchio effect and the Cold Stress Test: Lies and thermography
Authors: Moliné A. , Gálvez‐García G. , Fernández‐Gómez J. , De la Fuente J. , Iborra O. , Tornay F. , Mata Martín J. L. , Puertollano M. , Gómez Milán E. 
Published: July 2017

AbstractWe applied the use of thermography to cognitive neuropsychology, particularly as an objective marker of subjective experiences, in the context of lying. We conducted three experiments: (a) An important lie was invented by the participants in 3 min, and it was recounted by phone to a significant person while they were recorded by the thermographic camera, obtaining a face and hands map of the lie. (b) A similar methodology was carried out, but adding the Cold Stress Test (CST) of the dominant hand during the phone call, obtaining a second physiologic marker (the percentage of thermal recovery) to detect the lie. Further, it established a control condition where it generated anxiety in the participants using IAPS images with negative valence and high arousal, which were described by phone to a loved one. We obtained results that showed significant correlations between changes in body temperature and mental set. Of particular interest was the temperature of the nose and hand, which tended to decrease during lying (Experiment 1). The participants also showed a lower recovery of the temperature after the CST when they were lying (Experiment 2). (c) Experiment 3 is a replication of Experiment 2 but with a different type of lie (a more ecological task) in a different scenario (following the ACID interview, with the use of the phone eliminated and participants motivated to lie well). The main pattern of results was replicated. We obtained an accuracy of 85% in detection of deception with 25% of false alarms.
Cytokine profiles in Tibetan macaques following α‐1,3‐galactosyltransferase‐knockout pig liver xenotransplantation
Authors: Zhang Zhuochao , Li Xiao , Zhang Hong , Zhang Xuan , Chen Hui , Pan Dengke , Ji Hongchen , Zhou Liang , Ling Juan , Zhou Jingshi , Yue Shuqiang , Wang Desheng , Yang Zhaoxu , Tao Kaishan , Dou Kefeng 
Published: July 2017

AbstractBackgroundPig‐to‐nonhuman primate orthotopic liver xenotransplantation is often accompanied by thrombocytopenia and coagulation disorders. Furthermore, the release of cytokines can trigger cascade reactions of coagulation and immune attacks within transplant recipients. To better elucidate the process of inflammation in liver xenograft recipients, we utilized a modified heterotopic auxiliary liver xenotransplantation model for xeno‐immunological research. We studied the cytokine profiles and the relationship between cytokine levels and xenograft function after liver xenotransplantation.MethodsAppropriate donor and recipient matches were screened using complement‐dependent cytotoxicity assays. Donor liver grafts from α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs or GTKO pigs additionally transgenic for human CD47 (GTKO/CD47) were transplanted into Tibetan macaques via two different heterotrophic auxiliary liver xenotransplantation procedures. The cytokine profiles, hepatic function, and coagulation parameters were monitored during the clinical course of xenotransplantation.ResultsXenograft blood flow was stable in recipients after heterotopic auxiliary transplantation. A Doppler examination indicated that the blood flow speed was faster in the hepatic artery (HA) and hepatic vein (HV) of xenografts subjected to the modified Sur II (HA‐abdominal aorta+HV‐inferior vena cava) procedure than in those subjected to our previously reported Sur I (HA‐splenic artery+HV‐left renal vein) procedure. Tibetan macaques receiving liver xenografts did not exhibit severe coagulation disorders or immune rejection. Although the recipients did suffer from a rapid loss of platelets, this loss was mild. In blood samples dynamically collected after xenotransplantation (post‐Tx), dramatic increases in the levels of monocyte chemoattractant protein 1, interleukin (IL)‐8, granulocyte‐macrophage colony‐stimulating factor, IL‐6, and interferon gamma‐induced protein 10 were observed at 1 hour post‐Tx, even under immunosuppression. We further confirmed that the elevation in individual cytokine levels was correlated with the onset of graft damage. Finally, the release of cytokines might contribute to leukocyte infiltration in the xenografts.ConclusionHere, we established a modified auxiliary liver xenotransplantation model resulting in near‐normal hepatic function. Inflammatory cytokines might contribute to early damage in liver xenografts. Controlling the systemic inflammatory response of recipients might prevent early post‐Tx graft dysfunction.
Sex differences in angiotensin II‐stimulated fluid intake
Authors: Santollo Jessica 
Published: July 2017

New Findings
What is the topic of this review?
This report describes sex differences in the responses to angiotensin II, with a focus on fluid intake.

What advances does it highlight?
There are conflicting reports on the direction of the sex difference in fluid intake in response to angiotensin II. This review highlights how accounting for differences in body weight contributes to the discrepancies in the literature. In certain conditions, body weight influences fluid intake in a sex‐specific manner. This review also highlights the divergent effects of oestrogen receptor activation on fluid intake, which are likely to underlie the discussed sex differences.

Sex has a clear effect on the renin–angiotensin–aldosterone system. Although sex differences in the pressor response to angiotensin II (Ang II) are well established, understanding of the sex differences in the fluid intake response to Ang II is clouded by conflicting reports. Here, I suggest that accounting for differences in body weight contributes to the discrepancies in the literature. Our recent findings demonstrate that body weight influences Ang II‐stimulated water intake in certain conditions in male, but not in female rats. When differences in body weight are corrected for in the appropriate circumstances, we found that males consume more water in response to Ang II compared with females. Males and females also show differences in drinking microstructure, i.e. bottle spout lick patterns, which provide clues into the mechanism(s) underlying this sex difference. Oestrogens, which inhibit Ang II‐stimulated fluid intake and circulate at higher concentrations in females, are likely to contribute to this sex difference. This review also discusses the diversity in oestrogen signalling via multiple oestrogen receptor subtypes, which selectively inhibit Ang II‐stimulated fluid intake.
Quadriceps and Patient-Reported Function in ACL-Reconstructed Patients: A Principal Component Analysis
Authors: Norte Grant E. , Hertel Jay N. , Saliba Susan A. , Diduch David R. , Hart Joseph M. 
Published: July 2017

Context: Assessment of physical function for individuals after anterior cruciate ligament reconstruction (ACL-R) is complex and warrants the use of diverse evaluation strategies. To maximize the efficiency of assessment, there is a need to identify tests that provide the most meaningful information about this population. Objective: To investigate underlying constructs of quadriceps muscle function that uniquely describe aspects of performance in patients after ACL-R and establish clinical thresholds for measures able to classify patients with and without ACL-R. Design: Cross-sectional. Setting: Research laboratory. Patients (or Other Participants): Seventy-two patients with a primary, unilateral ACL-R (32 males and 40 females, age = 26.0 [9.3] y, time since surgery = 46.5 [58.0] mo) and 30 healthy controls (12 males and 18 females, age = 22.7 [4.6] y). Intervention(s): Quadriceps function was assessed bilaterally during 1 study visit. Main Outcome Measures: Isokinetic strength (peak torque, total work, and average power) at 90° and 180°/s, maximal voluntary isometric contraction torque, fatigue index, central activation ratio, Hoffmann reflex, and active motor threshold. Principal component analyses were performed for the involved limb, contralateral limb, and limb symmetry. Receiver–operator characteristic curve analyses were conducted to determine the diagnostic utility of each variable. Binary logistic regression was used to predict group membership (ACL-R vs healthy). Results: Three components of peripheral, central, and combined (peripheral and central) muscle function were identified, explaining 70.7% to 80.5% of variance among measures of quadriceps function. Total knee-extensor work at 90°/s (≥18.4 J/kg), active motor threshold (≥39.5%), and central activation ratio (≥94.7%) of the involved limb were strong predictors of patient status and correctly classified 83.5% of patients with ACL-R (P < .001). Conclusions: Unique constructs of peripheral, central, and combined muscle function exist in patients with ACL-R. Total knee-extensor work at 90°/s, active motor threshold, and central activation ratio consistently explained a significant portion of variance in measures of quadriceps function, demonstrated acceptable to excellent diagnostic utility, and predicted group membership with 72.8% to 83.5% accuracy.
Developing patient education to enhance recovery after colorectal surgery through action research: a qualitative study
Authors: Poland Fiona , Spalding Nicola , Gregory Sheila , McCulloch Jane , Sargen Kevin , Vicary Penny 
Published: July 2017

ObjectivesTo understand the role of preoperative education for patients undergoing colorectal surgery by involving patients, carers and staff in: (1) identifying its perceived value and deficits for enhanced recovery; (2) modifying current education practices to address educational deficits; and (3) evaluating these changes for preparing patients to enhance their recovery.DesignQualitative study of three cycles of action research using mixed methods within a 24-month naturalistic enquiry to identify, implement and evaluate changes through observations, questionnaires, semistructured longitudinal interviews, focus groups and documentation review.SettingA UK 1200-bed National Health Service (NHS) hospital providing colorectal surgery in a small city in a rural county.ParticipantsNinety-sevenpatients having colorectal surgery, 19 carers and 22 clinical staff.ResultsThemes identified were: (1) knowledge and engagement; (2) situated understanding and confidence building; and (3) partnership and proactive involvement in enhancing recovery. All patients articulated needs to prepare mentally and physically to plan for colorectal surgery and rehabilitation. Patients and carers wanted to counter uncertainty about medical procedures: likely bodily changes, recovery timescales and future. They therefore sought as much personalised, relevant information as possible about their disease, planned surgery and recovery. Staff implemented preoperative education to more specifically inform and respond multimodally to individual needs.ConclusionsPatients wanted to be proactively involved in managing their recovery to re-engage with their everyday lives. Preoperative education supported this through developing patients’ situated understanding of hospital and bodily processes related to colorectal surgery. Situated understanding was achieved through educational product to give knowledge and processes promoting engagement. Multimodal, comprehensive and timely preoperative education on the whole patient pathway facilitates active engagement. Situated understanding increased patients’ confidence to work in partnership with healthcare professionals and proactively self-manage recovery.
Consequences of maternal morbidity on health-related functioning: a systematic scoping review
Authors: Machiyama Kazuyo , Hirose Atsumi , Cresswell Jenny A , Barreix Maria , Chou Doris , Kostanjsek Nenad , Say Lale , Filippi Véronique 
Published: July 2017

ObjectivesTo assess the scope of the published literature on the consequences of maternal morbidity on health-related functioning at the global level and identify key substantive findings as well as research and methodological gaps.MethodsWe searched for articles published between 2005 and 2014 using Medline, Embase, Popline, CINAHL Plus and three regional bibliographic databases in January 2015.DesignSystematic scoping reviewPrimary outcomeHealth-related functioningResultsAfter screening 17 706 studies, 136 articles were identified for inclusion. While a substantial number of papers have documented mostly negative effects of morbidity on health-related functioning and well-being, the body of evidence is not spread evenly across conditions, domains or geographical regions. Over 60% of the studies focus on indirect conditions such as depression, diabetes and incontinence. Health-related functioning is often assessed by instruments designed for the general population including the 36-item Short Form or disease-specific tools. The functioning domains most frequently documented are physical and mental; studies that examined physical, mental, social, economic and specifically focused on marital, maternal and sexual functioning are rare. Only 16 studies were conducted in Africa.ConclusionsMany assessments have not been comprehensive and have paid little attention to important functioning domains for pregnant and postpartum women. The development of a comprehensive instrument specific to maternal health would greatly advance our understanding of burden of ill health associated with maternal morbidity and help set priorities. The lack of attention to consequences on functioning associated with the main direct obstetric complications is of particular concern.Review registrationCRD42015017774
Quality of life, treatment satisfaction and efficacy of non-biological systemic therapies in patients with plaque psoriasis: study protocol for a prospective observational study
Authors: Fink Christine , Schank Timo E , Trenkler Nina , Uhlmann Lorenz , Schäkel Knut 
Published: July 2017

IntroductionPsoriasis vulgaris often leads to a significant impaired quality of life and dissatisfaction with the existing therapeutic approaches. However, patients’ quality of life and treatment satisfaction are of utmost importance, since it is positively related to therapy adherence and encourages patient’s compliance. The study described herein evaluates the quality of life, treatment satisfaction and efficacy during the initial 6 months of treatment with a non-biological systemic agent in a real-life clinical setting.Methods and analysisThis observational study compares quality of life, treatment satisfaction and the efficacy of non-biological systemic therapy between 60 patients suffering from plaque psoriasis receiving the non-biological systemic therapies with apremilast, methotrexate and fumaric acid esters.Ethics and disseminationEthics approval was provided by the ethics committee of the medical faculty of the University of Heidelberg. Ethics approval number is S-298/2015. The design and the final results of the study will be published and made available to the public.Trial registration numberGerman Clinical Trial Register (DRKS): DRKS00008721 (https://www.germanctr.de/).