bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Coke‐Resistant Catalyst Using NiAl2O4 Support for Hydrogen Production via Autothermal Dry Reforming of Methane
Authors: Khani Yasin , Pyo Sumin , Bahadoran Farzad , Cho Kanghee , Jeong Kwang‐Eun , Park Young‐Kwon 
Published: September 2024

AbstractA highly porous NiAl2O4 spinel structure was synthesized and employed as a support for catalysts in the autothermal dry reforming of methane (ATDRM) in a monolithic‐type reactor. A series of catalysts with various metal species, X/NiAl2O4@monolith (X: Ni, Co, Pt, Rh, and Ru), was prepared. NiAl2O4 support provides a high dispersion of active metal species with a uniform size distribution, due to its high surface area, and large pore volume. These features enable catalysts to maximize catalytic performance by improving the adsorption and reaction rates of reactants. More notably, the use of NiAl2O4 support enhanced catalyst longevity by retarding coke formation during the ATDRM, due to its improved catalyst acidity compared to conventional alumina support. The conversion of feed, CH4 and CO2 on X/NiAl2O4 catalysts increases in the order of Rh > Ni > Ru > Co > Pt. Notably, the inexpensive Ni catalyst exhibits slightly lower but comparable CH4 conversion to the expensive noble metal Rh when using NiAl2O4 as a supporting material: 93.7% for Ni versus 95.2% for Rh. Moreover, applying monolithic reactors considerably increased methane conversion compared with fixed bed reactors due to the better distribution of active metal, increased activity per unit volume, and high mass/heat transfer.
Effect of Mg Doping on the Performance of LiNi0.9Co0.1O2 Cathode for Lithium‐Ion Batteries
Authors: Su Yang , Ren Hai‐lin , Dong Li‐Zhong , Zhao Shuai , Wang Xiao‐min , Li Jia‐Qi 
Published: September 2024

AbstractHigh‐nickel cathode materials are widely used in lithium‐ion batteries because of their advantages of high energy density and high safety. High‐nickel cathode materials need to further improve cycling stability because they are prone to structural changes and capacity degradation. This paper proposes a method to improve high‐nickel cathode materials by Mg doping. XRD proves that Mg‐doped high‐nickel materials still have R‐3 m spatial structural characteristics; Rietveld refinement confirms that the c‐axis gradually increases with the increase of Mg content. Combined with DFT calculations, the presence of Mg can inhibit structural collapse during charge and discharge, reduce Li/Ni antisite defects, improve the electronic conductivity of the material, and improve the cyclic stability of the material. The 0.6 mol % Mg‐doped sample has an initial discharge capacity of 233 mAh g−1 at 0.1 C in the range of 2.7–4.3 V, a capacity retention rate of 91.0 % after 50 cycles at 1 C, still retains 79.9 % after 100 cycles. The dQ/dV curves further indicate that the presence of Mg improves the structural stability of the material.
Oxygen In The Mix: Is Oxic Microbial Electrosynthesis A Potential Alternative For Biomass Production?
Authors: Eberhard Reiner Johannes , Korth Benjamin , Edel Miriam 
Published: September 2024

AbstractOxic microbial electrosynthesis (oMES) allows the utilization of renewable electricity and industrial gas streams containing CO2 and O2 for biomass production by cultivating aerobic, autotrophic, hydrogen‐oxidizing bacteria, commonly known as Knallgas bacteria. oMES is likely not a direct competitor to conventional anoxic microbial electrosynthesis as harnessing aerobic hydrogen‐oxidizing bacteria depends on energetically inefficient assimilatory CO2 reduction pathways. However, it might be a complementary approach to classical biomass production from the perspective of limited land use and the availability of cheap renewable energy. The best characterized Knallgas bacterium is Cupriavidus necator. Extensively studied as lithoautotrophic production host, C. necator already offers a broad arsenal of genetic tools. In contrast, mechanistical knowledge about the recently discovered Kyrpidia spormannii is limited, but this species shows remarkable growth when cultivated as cathodic biofilm in bioelectrochemical systems. In addition, first experiments indicate a low energy demand for biomass production, which is in the order of magnitude of gas fermentation with C. necator or heterotrophic and methanotrophic technologies. Still, many aspects of the electrochemical cultivation of K. spormannii need to be better understood and rigorously improved to be a competitive technology in the making, including electron transfer and microbial kinetics, cultivation conditions, mass and energy balances, and reactor design.
Waste Valorization in a Sustainable Bio‐Based Economy: The Road to Carbon Neutrality
Authors: Sheldon Roger A. 
Published: September 2024

AbstractThe development of sustainable chemistry underlying the quest to minimize and/or valorize waste in the carbon‐neutral manufacture of chemicals is followed over the last four to five decades. Both chemo‐ and biocatalysis have played an indispensable role in this odyssey. in particular developments in protein engineering, metagenomics and bioinformatics over the preceding three decades have played a crucial supporting role in facilitating the widespread application of both whole cell and cell‐free biocatalysis. The pressing need, driven by climate change mitigation, for a drastic reduction in greenhouse gas (GHG) emissions, has precipitated an energy transition based on decarbonization of energy and defossilization of organic chemicals production. The latter involves waste biomass and/or waste CO2 as the feedstock and green electricity generated using solar, wind, hydroelectric or nuclear energy. The use of waste polysaccharides as feedstocks will underpin a renaissance in carbohydrate chemistry with pentoses and hexoses as base chemicals and bio‐based solvents and polymers as environmentally friendly downstream products. The widespread availability of inexpensive electricity and solar energy has led to increasing attention for electro(bio)catalysis and photo(bio)catalysis which in turn is leading to myriad innovations in these fields.
Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier
Authors: Craciun Bogdan‐Florin , Rosca Irina , Peptanariu Dragos , Pinteala Mariana 
Published: September 2024

AbstractThere is an emerging necessity for improved therapies against Candida‐related infections, with significant implications for global healthcare. Current antifungal agents, limited in number, target specific pathways, but resistance remains a concern. Flucytosine (5FC) exhibits antifungal activity, particularly against Candida. However, monotherapy efficacy is limited, necessitating combination treatments. Herein, we report PEGylated squalene‐based nanocarriers for 5FC loading, aiming to enhance its monotherapy efficacy against Candida strains. The loading of 5FC within micelles was achieved using the ultrasound‐assisted solvent evaporation method. The 5FC‐loaded micelles, together with non‐loaded micelles, were thoroughly characterized and analyzed. STEM and DLS analysis confirmed the core‐shell morphology with nanometric dimensions along with improved colloidal stability. The quantification of drug loading efficiency and drug loading capacity was calculated using the UV‐Vis technique. The in vitro drug‐release studies in simulated physiological conditions showed sustained release within 48 hours. Moreover, the release kinetics calculated using mathematical models showed a Fickian diffusion drug release mechanism in simulated physiological conditions with a slower diffusion rate. The in vitro antifungal activity was tested on Candida albicans, Candida glabrata, and Candida parapsilosis. The results showed improved antifungal activity for the nanotherapeutic and unchanged in vitro toxicity toward normal cells, suggesting promising advancements in 5FC therapy.
Rapid and Robust Polysome Isolation and Fraction RNA Extraction for Studying the Seed Translatome
Authors: Duong Ha Ngoc , Ansaf Huda , Cornish Peter , Mendoza‐Cozatl David , Schenck Craig , Angelovici Ruthie 
Published: September 2024

AbstractTranslation of mRNA into functional proteins is a fundamental process underlying many aspects of plant growth and development. Yet, the role of translational regulation in plants across diverse tissue types, including seeds, is not well known due to the lack of methods targeting these processes. Studying the seed translatome could unveil seed‐specific regulatory mechanisms, offering valuable insights for breeding efforts to enhance seed traits. Polysome profiling is a widely used technique for studying mRNAs being translated. However, the traditional method is time‐consuming and has a low polysome recovery rate; therefore, it requires substantial starting material. This is particularly challenging for species or mutants with limited seed quantities. Additionally, seed polysome fractions often yield low quality RNA due to the abundance of various compounds that interfere with conventional RNA extraction protocols. Here we present a robust polysome extraction method incorporating a size‐exclusion step for polysome concentration streamlined with a rapid RNA extraction method optimized for seeds. This protocol works across multiple plant species and offers increased speed and robustness, requiring less than half the amount of seed tissue and time compared to conventional methods while ensuring high polysome recovery and yield of high‐quality RNA for downstream experiments. These features make this protocol an ideal tool for studying seed translation efficiency and hold broad applicability across various plant species and tissues. © 2024 Wiley Periodicals LLC.Basic Protocol 1: Robust polysome extraction for seedsBasic Protocol 2: Rapid fraction total RNA extraction
Quantifying Intracellular Platinum Accumulation Using Inductively Coupled Mass Spectrometry
Authors: Krishnaraj Arun , Nair Sreejith J. 
Published: September 2024

AbstractThe platinum‐based anticancer drug cisplatin and its analog carboplatin are the most used chemotherapeutic agents worldwide. It is estimated that approximately half of all cancer patients are treated with platinum drugs at some point during the therapy regimen. Cisplatin covalently binds to purine nucleobases to form DNA adducts. Cisplatin therapy is faced with two key challenges. First, despite the initial response, many patients develop cisplatin resistance. Reduced cellular accumulation of cisplatin is one common cause of therapy resistance. Second, cisplatin treatment causes general cytotoxicity, leading to severe side effects. Monitoring the subcellular concentration of platinum chemotherapeutics will help yield clinical efficacy with the minimum possible dose. Inductively coupled plasma‐mass spectrometry (ICP‐MS) is an analytical technique to quantify the elemental composition of various types of liquified bulk samples with high sensitivity. This article describes quantifying cisplatin accumulation in chromatin and total cell lysate using ICP‐MS. The method involves treating cells with cisplatin, isolating RNA‐free DNA, digesting samples, ICP‐MS instrumentation, and data analysis. Although we describe these steps in one cancer cell line, the protocol can be adapted to any cell line or tissue. The protocol should be a valuable resource for investigators interested in accurate measurement of subcellular concentration of platinum and other metallo‐drugs. © 2024 Wiley Periodicals LLC.Basic Protocol 1: Cell culture conditions for A2780 cells and cisplatin treatmentBasic Protocol 2: Isolating cellular fractions and sample quantitationBasic Protocol 3: Sample digestion, ICP‐MS data collection, and analysis
Anticipatory and Consummatory Responses Across Reward Domains in Adolescents With Anorexia Nervosa
Authors: Pines Julia , Hagan Kelsey , Lloyd Caitlin , Raffanello Elizabeth , Hong Susie , Posner Jonathan , Walsh B. Timothy , Steinglass Joanna E. 
Published: September 2024

ABSTRACTObjectiveAnorexia nervosa (AN) is characterized by a tendency to limit intake of food, with specific restriction of foods that are generally considered highly palatable. This observation raises questions about whether reward processing is disturbed in AN. This study examined whether adolescents with AN differ from healthy control peers (HC) in anticipatory and consummatory reward processing.MethodAdolescents with AN (n = 71) and HC (n = 41) completed the Temporal Experience of Pleasure Scale (TEPS). The TEPS Anticipatory Pleasure scale was divided into two further subscales (Food and Non‐food). Anticipatory (Food and Non‐food) and Consummatory Pleasure (Non‐food) scores were compared between adolescents with AN and HC using independent t‐tests.ResultsTEPS scores were significantly lower among adolescents with AN than HC in Anticipatory Pleasure Food (t(110) = 7.80, p < 0.001) and Non‐food (t(110) = 4.36, p < 0.001), and Consummatory Pleasure (t(110) = 2.60, p = 0.01) subscales. When controlling for BDI score, there was no significant group difference in TEPS Consummatory Pleasure scores (t(108) = 0.88, p = 0.38). Among adolescents with AN, Food Anticipatory Pleasure was significantly negatively correlated with all EDE‐Q subscales and global score (r(68) = −0.38, p = 0.002) and positively correlated with food intake at a laboratory buffet meal (r(61) = 0.53, p < 0.001).DiscussionMeasures of both anticipatory and consummatory reward were reduced among adolescents with AN with a short duration of illness. In this study, eating disorder symptoms were related to diminished reward responses in anticipation of food. Dampened anticipatory reward response may comprise a mechanism of illness in AN that should be subject to further study.
Thermal biology diversity of bee pollinators: Taxonomic, phylogenetic, and plant community‐level correlates
Authors: Herrera Carlos M. 
Published: September 2024

AbstractCommunity‐wide assembly of plant–pollinator systems depends on an intricate combination of biotic and abiotic factors, including heterogeneity among pollinators in thermal biology and responses to abiotic factors. Studies on the thermal biology of pollinators have mostly considered only one or a few species of plants or pollinators at a time, and the possible driving role of the diversity in thermal biology of pollinator asemblages at the plant community level remains largely unexplored. More specifically, it is unknown whether diversity in the thermal biology of bees, a major pollinator group worldwide, contributes to the assembly and maintenance of diverse bee communities; broadens the spectrum of possibilities available to bee‐pollinated plants; facilitates interspecific partitioning of ecological gradients across habitats, seasons, and time of day; and/or enhance plant pollination success through complementarity effects. The objectives of this study were to assess the diversity in thermal biology of the bee assemblage that pollinates plants in a Mediterranean montane area, evaluate its taxonomic and phylogenetic underpinnings, and elucidate whether there existed seasonal, daily, between‐habitat, or floral visitation correlates of bee thermal biology which could contribute to partition ecological gradients among plant and bee species. Thermal biology parameters were obtained in the laboratory (K, intrinsic warming constant) and the field (thoracic and ambient temperature at foraging site, Tth and Tair) on individual bees of a diverse sample (N = 204 bee species) comprising most bee pollinators of the regional plant community. Species‐specific thermal biology parameters were combined with quantitative field data on bee pollinators and flower visitation for the regional community of entomophilous plants (N = 292 plant species). Results revealed that the regional bee assemblage harbored considerable diversity in thermal biology features; that such diversity was mostly taxonomically, phylogenetically, and body‐size structured; and that the broad interspecific heterogeneity in thermal biology represented in the bee community as a whole eventually translated into daily, seasonal, among‐habitat, and flower visitation patterns at the plant community level. This lends support to the hypothesis that broad diversity in thermal biology of bees can enhance opportunities for bee coexistence, spatiotemporal partitioning of floral resources, and plant pollination success.
Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX‐AHF‐2 trial
Authors: Inciardi Riccardo M. , Staal Laura , Davison Beth , Lombardi Carlo M. , Postmus Douwe , Felker Michael G. , Filippatos Gerasimos , Greenberg Barry , Pang Peter S. , Ponikowski Piotr , Severin Thomas , Gimpelewicz Claudio , Teerlink John , Cotter Gad , Voors Adriaan A. , Metra Marco 
Published: September 2024

AbstractAimsAcute heart failure (AHF) is a major cause of hospitalizations and death in the elderly. However, elderly patients are often underrepresented in randomized clinical trials. We analysed the impact of age on clinical outcomes and response to treatment in patients enrolled in Relaxin in Acute Heart Failure (RELAX‐AHF‐2), a study that included older patients than in previous AHF trials.Methods and resultsThe RELAX‐AHF‐2 randomized patients admitted for AHF to infusion of serelaxin or placebo. We examined the association of pre‐specified clinical outcomes and treatment effect according to age categories [(years): <65 (n = 1411), 65–74 (n = 1832), 75–79 (n = 1222), 80–84 (n = 1156) and ≥85 (n = 924)]. The mean age of the 6545 patients enrolled in RELAX‐AHF‐2 was 73.0 ± 11 years. The risk of all‐cause and cardiovascular (CV) death (all p < 0.001) as well as the composite endpoint of CV death or heart failure/renal failure rehospitalization through 180 days (p = 0.002) and hospital discharge through day 60 (p = 0.013) were all directly associated with age categories. Age remained independently associated with outcomes after adjustment for clinical confounders and the results were consistent when age was analysed continuously. No clinically significant change in treatment effects of serelaxin was observed across age categories for the pre‐specified endpoints (interaction p > 0.05).ConclusionElderly patients are at higher risk of short‐ and long‐term CV outcomes after a hospitalization for AHF. Further efforts are needed to improve CV outcomes in this population.
Partially Fluorinated Alumina With Enhanced Stability: Application To Catalysis Under Aggressive Conditions
Authors: Blin Jean‐Luc , Dieu Julien , Lebeau Benedicte , Michelin Laure , Rigolet Séverinne , Brunet Sylvette 
Published: September 2024

AbstractHere, we report the design of new aluminum hydroxyfluoride, mainly composed of amorphous phase, with enhanced stability under HF gas in term of textural properties, especially the specific surface area and the acidity. The material has been synthesized through an EISA (evaporation‐induced self‐assembly) route using liquid crystals as templates. Thanks to this stability, the catalyst designed by the dispersion of the active phase on this support shows a higher accessibility and activity of the active sites than the ones obtained by other methods
How parent–teacher relationship affects Chinese pupils' school attitudes? The moderation of students' perceptions of academic performance
Authors: Zhou Xinran , Zhang Mingming , Liang Lichan , Bian Yufang 
Published: September 2024

AbstractAlthough the benefits of the close relationship between parent and teacher to child development are widely recognized, it's still unclear how the parent–teacher relationship affects Chinese pupils' school attitudes. The study aimed to investigate this question with a nuanced approach by focusing on the components of the parent–teacher relationship and exploring the moderation of students' perceptions of academic performance. Data were from 1755 fifth graders (M
age = 12.19, 51.3% girls) and their mothers (M
age = 41.38) in a two‐wave longitudinal dataset. Parents' reports of parent‐initiated contact, teacher‐initiated contact, the quality of the parent–teacher relationship, and students' perceptions of school attitudes and academic performance were analysed by multiple regression models. In terms of the main effect, parent–teacher relationship quality was negatively associated with school avoidance. In terms of the moderation effects, parent‐initiated contact was negatively associated with students' school liking who had low academic perceptions, and the relationship quality was positively associated with students' school liking who had high academic perceptions. The findings provide insights into promoting pupils' school psychological adjustment from the perspective of home–school collaboration in the Chinese context.
14‐3‐3σ restricts YY1 to the cytoplasm, promoting therapy resistance, and tumor progression in colorectal cancer
Authors: Lonare Amol , Raychaudhuri Kumarkrishna , Shah Sanket , Madhu Gifty , Sachdeva Anoushka , Basu Sneha , Thorat Rahul , Gupta Sanjay , Dalal Sorab N. 
Published: September 2024

Abstract14‐3‐3σ functions as an oncogene in colorectal cancer and is associated with therapy resistance. However, the mechanisms underlying these observations are not clear. The results in this report demonstrate that loss of 14‐3‐3σ in colorectal cancer cells leads to a decrease in tumor formation and increased sensitivity to chemotherapy. The increased sensitivity to chemotherapy is due to a decrease in the expression of UPR pathway genes in the absence of 14‐3‐3σ. 14‐3‐3σ promotes expression of the UPR pathway genes by binding to the transcription factor YY1 and preventing the nuclear localization of YY1. YY1, in the absence of 14‐3‐3σ, shows increased nuclear localization and binds to the promoter of the UPR pathway genes, resulting in decreased gene expression. Similarly, a YY1 mutant that cannot bind to 14‐3‐3σ also shows increased nuclear localization and is enriched on the promoter of the UPR pathway genes. Finally, inhibition of the UPR pathway with genetic or pharmacological approaches sensitizes colon cancer cells to chemotherapy. Our results identify a novel mechanism by which 14‐3‐3σ promotes tumor progression and therapy resistance in colorectal cancer by maintaining UPR gene expression.
Ureteral cancer successfully treated with laparoscopic nephroureterectomy with temporary intraoperative occlusion of the internal iliac artery for pelvic arteriovenous malformation
Authors: Koyama Juntaro , Sato Tomonori , Sato Yasufumi , Sato Shin , Shimada Shuichi , Taniuchi Shinji , Tsuchida Ken , Tsuboi Masahiro , Sakamoto Kazuhiro , Ikeda Yoshihiro 
Published: September 2024

IntroductionPelvic arteriovenous malformation is often a source of intraoperative bleeding. Here, we report our experience with a case of ureteral cancer with pelvic arteriovenous malformation treated using laparoscopic nephroureterectomy with temporary intraoperative occlusion of the internal iliac artery.Case presentationA 75‐year‐old man presented to our hospital with asymptomatic macro‐hematuria. Contrast‐enhanced computed tomography revealed right ureteral tumor with no apparent metastases, and right pelvic arteriovenous malformation. Three months later, multiple bladder cancers were identified and the patient underwent trans‐urethral resection of bladder tumor. The pathological diagnosis was urothelial carcinoma, pTa. We performed right laparoscopic nephroureterectomy with temporary intraoperative occlusion of the internal iliac artery. There was little intraoperative bleeding, and the surgery was safely completed. The pathological diagnosis was urothelial carcinoma, pT2 + Tis.ConclusionA patient showing ureteral cancer with pelvic arteriovenous malformation was safely treated using laparoscopic nephroureterectomy with temporary occlusion of the internal iliac artery.