bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 1 study of quizartinib in combination with induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia
Authors: Altman Jessica K. , Foran James M. , Pratz Keith W. , Trone Denise , Cortes Jorge E. , Tallman Martin S. 
Published: November 2017

AbstractNovel therapies have potential to improve outcomes in patients with acute myeloid leukemia (AML) harboring FLT3‐ITD mutations that have high risk of relapse and poor survival following standard of care (SOC) cytarabine/anthracycline‐based induction/consolidation chemotherapy. Quizartinib is a selective and highly potent FLT3 inhibitor that has shown strong single‐agent activity in relapsed or refractory (R/R) AML. This phase 1, open‐label, sequential group dose‐escalation trial (NCT 01390337) is the first evaluating safety and tolerability of quizartinib in combination with SOC chemotherapy in newly diagnosed AML (ndAML). Nineteen patients unselected for FLT3 mutational status received one of three quizartinib dihydrochloride dose levels (DL): 60 mg/d for 7 days (DL1; n = 6), 60 mg/d for 14 days (DL2; n = 7), and 40 mg/d for 14 days (DL‐1; n = 6); administered orally starting on day 4 of chemotherapy. Median age was 43.8 years. Ten patients completed induction and consolidation. Three patients experienced dose‐limiting toxicities (DLTs): 2 at DL2 (1 pericardial effusion; 1 febrile neutropenia, decreased platelet count, and QT prolongation); 1 at DL‐1 (pericarditis). Maximum tolerated dose (MTD) was identified as DL‐1. Most common grade 3/4 adverse events were febrile neutropenia (47%), neutropenia (42%), thrombocytopenia (32%), and anemia (26%). There were no apparent additional toxicities with addition of quizartinib to chemotherapy although grade ≤1 QT prolongation was observed at MTD. Sixteen patients (84%) achieved a response; 14 (74%) composite complete response; 2 (11%) morphologic leukemia‐free state. The phase 3 QuANTUM‐First trial (NCT02668653) is further evaluating the effect of quizartinib plus SOC chemotherapy in ndAML FLT3‐ITD mutated patients.
Ancestry and dental development: A geographic and genetic perspective
Authors: Dhamo Brunilda , Kragt Lea , Grgic Olja , Vucic Strahinja , Medina‐Gomez Carolina , Rivadeneira Fernando , Jaddoe Vincent W.V. , Wolvius Eppo B. , Ongkosuwito Edwin M. 
Published: November 2017

AbstractObjectiveIn this study, we investigated the influence of ancestry on dental development in the Generation R Study.MethodsInformation on geographic ancestry was available in 3,600 children (1,810 boys and 1,790 girls, mean age 9.81 ± 0.35 years) and information about genetic ancestry was available in 2,786 children (1,387 boys and 1,399 girls, mean age 9.82 ± 0.34 years). Dental development was assessed in all children using the Demirjian method. The associations of geographic ancestry (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani vs Dutch as the reference group) and genetic content of ancestry (European, African or Asian) with dental development was analyzed using linear regression models.ResultsIn a geographic perspective of ancestry, Moroccan (β = 0.18; 95% CI: 0.07, 0.28), Turkish (β = 0.22; 95% CI: 0.12, 0.32), Dutch Antillean (β = 0.27; 95% CI: 0.12, 0.41), and Surinamese Creole (β = 0.16; 95% CI: 0.03, 0.30) preceded Dutch children in dental development. Moreover, in a genetic perspective of ancestry, a higher proportion of European ancestry was associated with decelerated dental development (β = −0.32; 95% CI: –.44, –.20). In contrast, a higher proportion of African ancestry (β = 0.29; 95% CI: 0.16, 0.43) and a higher proportion of Asian ancestry (β = 0.28; 95% CI: 0.09, 0.48) were associated with accelerated dental development. When investigating only European children, these effect estimates increased to twice as large in absolute value.ConclusionBased on a geographic and genetic perspective, differences in dental development exist in a population of heterogeneous ancestry and should be considered when describing the physiological growth in children.
Hochselektive Mangan(I)/Lewis‐Säure‐cokatalysierte direkte C‐H‐Propargylierung unter Verwendung von Bromallenen
Authors: Zhu Can , Schwarz Jonas Luca , Cembellín Sara , Greßies Steffen , Glorius Frank 
Published: November 2017

AbstractEine Mangan(I)/Lewis‐Säure‐cokatalysierte direkte hochselektive C‐H‐Propargylierung wurde entwickelt. BPh3 erhöht bei dieser Propargylierung nicht nur die Reaktivität, sondern auch die Selektivität. Sekundäre, tertiäre und sogar quartäre Kohlenstoffzentren konnten in der propargylischen Position direkt aufgebaut werden. Sowohl interne als auch terminale Alkine können leicht gebildet werden. Die Chiralität konnte erfolgreich von einem axial‐chiralen Allen zu einem Chiralitätszentrum transferiert werden. Die Reaktivität des Mangan‐Katalysators in dieser Umsetzung ist im Vergleich zu anderen Übergangsmetallkatalysatoren einzigartig.
Graphene oxide/poly(ethylene glycol)/chitosan gel with slow‐release lubrication applied on textured surface
Authors: Ren Shanshan , Lu Hailin , Guo Junde , Li Yue , Li Xing , Li Jianhui , Dong Guangneng 
Published: November 2017

ABSTRACTGraphene oxide/poly(ethylene glycol) (GO/PEG) composites that have biocompatibility and biodegradability properties have been prepared to improve the lubrication of artificial joints, but they would be rapidly degraded and absorbed by the human body if injected. To prolong the lubrication effect, GO/PEG lubricants were mixed into a chitosan (CS) sol, and then the GO/PEG/CS sol was added to the dimpled texture of a Co‐Cr‐Mo alloy and transformed into a gel to slowly release GO/PEG lubricants. The results of friction experiments showed that the average friction coefficient of the slow‐release solution is below 0.025, especially when under pressure, and the gel in the texture also has a good lubrication effect. Meanwhile, the FTIR and UV–vis of the slow‐release solution indicated that it is likely to contain GO, PEG, and CS, which are associated with each other via hydrogen bonds and may form a particular structure, leading to good slow‐release lubrication. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2018,135, 45818.
Comb‐shaped copolymer as filtrate loss reducer for water‐based drilling fluid
Authors: Liu Lu , Pu Xiaolin , Rong Kesheng , Yang Yandong 
Published: November 2017

ABSTRACTA new comb‐shaped copolymer was synthesized by free radical copolymerization of 2‐acrylamide‐2‐methyl propane sulfonic acid, acrylamide, N‐vinyl‐2‐pyrrolidone, and allyl polyoxyethylene ether (APEG) monomers. The copolymer was evaluated as a filtrate loss reducer in water‐based drilling fluid at 180 °C environment, and found to work well without causing high viscosity effect. Composition of the copolymer was determined by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy, and gel permeation chromatography. FTIR, X‐ray diffraction,, and environmental scanning electron microscopy characterizations were used to probe the filtrate loss mechanism of the comb‐shaped copolymer. Thermogravimetry and differential scanning calorimetry results showed that thermal degradation of the copolymer is not obvious before 293.6 °C. The copolymer is found to be superior to its commercially available counterparts for controlling filtrate loss volume and maintaining a steady viscosity after 180 °C aging. Higher content of APEG in the copolymer helps maintain rheological properties of the drilling fluid after aging and reduces filtrate loss volume. The morphology of the copolymer in aqueous solution displays a comb‐shaped 3D structure and shows clear adsorption onto clay particles. The working mechanism for copolymer is that anchoring groups bind the copolymer onto clay particles through different binding mechanisms, while colloidal suspension stability is achieved by steric hindrance and electrostatic repulsion, as well as through PEG segment intercalation into clay lamellae. The copolymer is able to cover and seal the micro‐holes in the mud cake even at high temperature to reduce permeability. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45989.
Differentiation potential of human adipose stem cells bioprinted with hyaluronic acid/gelatin‐based bioink through microextrusion and visible light‐initiated crosslinking
Authors: Sakai Shinji , Ohi Hiromi , Hotta Tomoki , Kamei Hidenori , Taya Masahito 
Published: November 2017

AbstractBioprinting has a great potential to fabricate three‐dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs). The hydrogel was obtained from a solution of HA and gelatin derivatives possessing phenolic hydroxyl moieties in the presence of ruthenium(II) tris‐bipyridyl dication and sodium ammonium persulfate. hADSCs enclosed in the bioprinted hydrogel construct elongated and proliferated in the hydrogel. In addition, their differentiation potential was confirmed by examining the expression of pluripotency marker genes and cell surface marker proteins, and differentiation to adipocytes in adipogenic differentiation medium. Our results demonstrate the great potential of the bioprinting method and the resultant hADSC‐laden HA/gelatin constructs for applications in tissue engineering and regenerative medicine.
Identifying Worldviews on Corporate Sustainability: A Content Analysis of Corporate Sustainability Reports
Authors: Landrum Nancy E. , Ohsowski Brian 
Published: November 2017

AbstractCompanies commonly issue sustainability or corporate social responsibility (CSR) reports. This study seeks to understand worldviews of corporate sustainability, or the corporate message conveyed regarding what sustainability or CSR is and how to enact it. Content analysis of corporate sustainability reports is used to position each company report within stages of corporate sustainability. Results reveal that there are multiple coexisting worldviews of corporate sustainability, but the most dominant worldview is focused on the business case for sustainability, a position anchored in the weak sustainability paradigm. We contend that the business case and weak sustainability advanced in corporate sustainability reports and by the Global Reporting Initiative are poor representations of sustainability. Ecological embeddedness, or a locally responsive strategy that is sensitive to local ecosystems, may hold the key to improved ecological sensemaking, which in turn could lead to more mature levels of corporate sustainability worldviews that support strong sustainability and are rooted in environmental science. This must be supported by government regulation. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Hydroisomerization of Long‐Chain n‐Alkanes over Bifunctional Zeolites with 10‐Membered‐ and 12‐Membered‐Ring Pores
Authors: Zschiesche Christopher , Himsl Dieter , Rakoczy Rainer , Reitzmann Andreas , Freiding Jens , Wilde Nicole , Gläser Roger 
Published: November 2017

AbstractThe hydroisomerization of a C10–C13 n‐alkane mixture was investigated over six bifunctional platinum‐containing zeolite catalysts with 10‐ and 12‐membered‐ring pore systems. The catalysts with 12‐membered‐ring zeolites are more active than those with 10‐membered‐ring zeolites. In contrast, higher yields of the desired monobranched isomers are obtained over the 10‐membered‐ring zeolites due to shape‐selectivity effects. For the 10‐membered‐ring zeolites, higher reaction temperatures are required for achieving the maximum isomer yields, which leads to more cracking products compared to the 12‐membered‐ring zeolites.
Structure–Property Relationships in CuII‐Binding Tetramolecular G‐Quadruplex DNA
Authors: Engelhard David M. , Stratmann Lukas M. , Clever Guido H. 
Published: November 2017

AbstractA series of artificial metal–base tetrads composed of a CuII cation coordinating to four pyridines, covalently attached to the ends of tetramolecular G‐quadruplex DNA strands [LA–Dd(G4)]4 (LA–D=ligand derivatives), was systematically studied. Structurally, the square‐planar [Cu(pyridine)4] complex behaves analogously to the canonical guanine quartet. Copper coordination to all studied ligand derivatives was found to increase G‐quadruplex thermodynamic stability, tolerating a great variety of ligand linker lengths (1–5 atoms) and thus demonstrating the robustness of the chosen ligand design. Only at long linker lengths, the stabilizing effect of copper binding is compensated by the loss of conformational freedom. A previously reported ligand LE with chiral backbone enables incorporation at any oligonucleotide position. We show that ligand chirality distinctly steers CuII‐induced G‐quadruplex stabilization. 5′‐End formation of two metal–base tetrads by tetramolecular G‐quadruplex [LE2d(G)4]4 shows that stabilization in the presence of CuII is not additive. All results are based on UV/Vis thermal denaturation, thermal difference, circular dichroism experiments and molecular dynamics simulations.
Transient Simulation of Dopant Segregation at Facets During Growth of Nd:YAG Crystal
Authors: Hu Kaiwei 
Published: November 2017

AbstractNumerical simulation of faceting and dopant segregation for vertical Bridgman growth of Nd:YAG is presented. The numerical scheme for the interface tracking considers the coupling between kinetic model and thermal transport. Dopant distributes inhomogeneously at the radial direction of the crystal/melt interface and piles up in front of the interface near the crucible. The dopant concentration of faceted portions of the crystal/melt interface is higher than that of unfaceted surface. Effect of natural convection on dopant segregation at facets is studied. The dopant boundary layer thickness decreases with the enhancement of the natural convection. The scaling analysis of the dopant boundary layer thickness for facet surface is obtained.
Predictions of response to temperature are contingent on model choice and data quality
Authors: Low‐Décarie Etienne , Boatman Tobias G. , Bennett Noah , Passfield Will , Gavalás‐Olea Antonio , Siegel Philipp , Geider Richard J. 
Published: November 2017

AbstractThe equations used to account for the temperature dependence of biological processes, including growth and metabolic rates, are the foundations of our predictions of how global biogeochemistry and biogeography change in response to global climate change. We review and test the use of 12 equations used to model the temperature dependence of biological processes across the full range of their temperature response, including supra‐ and suboptimal temperatures. We focus on fitting these equations to thermal response curves for phytoplankton growth but also tested the equations on a variety of traits across a wide diversity of organisms. We found that many of the surveyed equations have comparable abilities to fit data and equally high requirements for data quality (number of test temperatures and range of response captured) but lead to different estimates of cardinal temperatures and of the biological rates at these temperatures. When these rate estimates are used for biogeographic predictions, differences between the estimates of even the best‐fitting models can exceed the global biological change predicted for a decade of global warming. As a result, studies of the biological response to global changes in temperature must make careful consideration of model selection and of the quality of the data used for parametrizing these models.
Diet reveals links between morphology and foraging in a cryptic temperate reef fish
Authors: Winkler Natalia S. , Paz‐Goicoechea Maite , Lamb Robert W. , Pérez‐Matus Alejandro 
Published: November 2017

AbstractPredators select prey so as to maximize energy and minimize manipulation time. In order to reduce prey detection and handling time, individuals must actively select their foraging space (microhabitat) and populations exhibit morphologies that are best suited for capturing locally available prey. We explored how variation in diet correlates with habitat type, and how these factors influence key morphological structures (mouth gape, eye diameter, fin length, fin area, and pectoral fin ratio) in a common microcarnivorous cryptic reef fish species, the triplefin Helcogrammoides cunninghami. In a mensurative experiment carried out at six kelp‐dominated sites, we observed considerable differences in diet along 400 km of the Chilean coast coincident with variation in habitat availability and prey distributions. Triplefins preferred a single prey type (bivalves or barnacles) at northern sites, coincident with a low diversity of foraging habitats. In contrast, southern sites presented varied and heterogeneous habitats, where triplefin diets were more diverse and included amphipods, decapods, and cumaceans. Allometry‐corrected results indicated that some morphological structures were consistently correlated with different prey items. Specifically, large mouth gape was associated with the capture of highly mobile prey such as decapods, while small mouth gape was more associated with cumaceans and copepods. In contrast, triplefins that capture sessile prey such as hydroids tend to have larger eyes. Therefore, morphological structures co‐vary with habitat selection and prey usage in this species. Our study shows how an abundant generalist reef fish exhibits variable feeding morphologies in response to the distribution of potential habitats and prey throughout its range.
High inbreeding and low connectivity among Ambystoma texanum populations in fragmented Ohio forests
Authors: Rhoads Elizabeth A. , Williams Patrick Kelly , Krane Carissa M. 
Published: November 2017

AbstractHabitat loss and fragmentation negatively impact the size and diversity of many natural populations. Woodland amphibians require connected aquatic and terrestrial habitats to complete their life cycle, and often rely on metapopulation structure for long‐term persistence. Wetland loss and deforestation fragment amphibian populations, which may result in population isolation and its negative effects. The aim of this research was to analyze the population genetic structure of small‐mouthed salamanders (Ambystoma texanum) in western Ohio, where agriculture is now the dominant land use. Salamander tail tissue was collected from eight breeding pools. Three pools occur in the same forest; the other five are in forest patches at distances ranging from 250 m to 20 km from one another. Eight microsatellite loci were amplified by PCR and genotyped for allele size. Observed heterozygosities were lower than expected in all sampled populations; the two most isolated sites (Ha1, Ha2) had the highest inbreeding coefficients. Ha2 also had the lowest mean number of alleles and was found to be genetically differentiated from populations to which our data analysis indicates it was historically connected by gene flow. The most distant site (Ha1) had the highest number of private alleles and showed genetic differentiation from other populations both historically and currently. Geographic distance between pools was strongly correlated with the number of private alleles in a population. The results suggest that population isolation results in decreased genetic diversity and that a breakdown of metapopulation structure due to landscape change may contribute to differentiation between once‐connected populations.
Plasma renin activity, response to aliskiren, and clinical outcomes in patients hospitalized for heart failure: the ASTRONAUT trial
Authors: Vaduganathan Muthiah , Cheema Baljash , Cleveland Erin , Sankar Kamya , Subacius Haris , Fonarow Gregg C. , Solomon Scott D. , Lewis Eldrin F. , Greene Stephen J. , Maggioni Aldo P. , Böhm Michael , Zannad Faiez , Butler Javed , Gheorghiade Mihai 
Published: November 2017

AimsThe direct renin inhibitor, aliskiren, is known to reduce plasma renin activity (PRA), but whether the efficacy of aliskiren varies based on an individual's baseline PRA in patients hospitalized for heart failure (HF) is presently unknown. We characterized the prognostic value of PRA and determined if this risk is modifiable with use of aliskiren.Methods and resultsThis pre‐specified neurohormonal substudy of ASTRONAUT analysed all patients hospitalized for HF with ejection fraction (EF) ≤40% with available baseline PRA data (n = 1306, 80.9%). Risk associated with baseline PRA and short‐term changes in PRA from baseline to 1 month was modelled with respect to 12‐month clinical events. Median baseline PRA was 3.0 (interquartile range 0.6–16.4) ng/mL/h. Aliskiren significantly reduced PRA early after treatment initiation through 12‐month follow‐up compared with placebo (P < 0.001). The lowest baseline PRA quartile (<0.6 ng/mL/h) was independently predictive of lower all‐cause mortality [adjusted hazard ratio (HR) 0.50, 95% confidence interval (CI) 0.31–0.81] and the composite of cardiovascular mortality and HF hospitalization (adjusted HR 0.57, 95% CI 0.40–0.79). Delta log‐normalized PRA (from baseline to 1 month) was not predictive of either primary endpoint at 12 months (P ≥ 0.43). The prognostic value of baseline PRA and short‐term changes in PRA did not vary by randomization to aliskiren or placebo (interaction P ≥ 0.13).ConclusionsPlasma renin activity is reduced early and durably by aliskiren, but this did not translate into improved clinical outcomes in ASTRONAUT. Baseline PRA or short‐term reduction in PRA do not identify a subgroup who may preferentially benefit from direct renin inhibition.Clinical Trial Registration ClinicalTrials.gov Unique Identifier: NCT00894387
Overcoming the Ambient‐Temperature Operation Limitation in Lithium‐Ion Batteries by using a Single‐Ion Polymer Electrolyte Fabricated by Controllable Molecular Design
Authors: Zhang Yunfeng , Pan Meize , Liu Xupo , Li Cuicui , Dong Jiaming , Sun Yubao , Zeng Danli , Yang Zehui , Cheng Hansong 
Published: November 2017

AbstractA polymer electrolyte with a particular molecular architecture plays a critical role in the improvement of the performances of both a polymer electrolyte and a battery device. Here, we present the design and synthesis of a sp3‐boron‐based single‐ion polymer electrolyte (SIPE), lithium poly(bisphenol AF borate) (LiPFB), by using partially aromatic bisphenol AF as a linker. As a result of the torsional, flexible, and strong electron‐withdrawing properties of the bistrifluoromethyl methylene group (−C(CF3)2−), the prepared poly(vinylidene fluoride‐co‐hexafluoropropene (PVDF‐HFP)/LiPFB membrane displays an enhanced ionic conductivity and a remarkable compatibility with electrodes compared to that of the PVDF‐HFP/lithium poly(4,4′‐biphenol borate) membrane, in which a linear and fully aromatic 4,4′‐biphenol is used as a linker. Consequently, an excellent battery performance both at room temperature and high charge/discharge rates was demonstrated. This study underscores the fundamental importance of the molecular structure of SIPE materials in battery performance enhancement and suggests ways to design new SIPE materials to enhance battery devices with improved electrochemical performance.