bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerbate DSS-induced inflammatory bowel disease
Authors: Hui Lu , Huang Meng-ke , Dai Qing-kai , Miao Cheng-lin , Yang Yun-long , Liu Chen-xi , Liu Ting , Jiang Yong-mei 
Published: September 2024

Abstract
Amlexanox (ALX) is a small-molecule drug for the treatment of inflammatory, autoimmune, metabolic, and tumor diseases. At present, there are no studies on whether ALX has a therapeutic effect on inflammatory bowel disease (IBD). In this study, we used a mouse model of dextran sulfate sodium-induced colitis to investigate the effect of ALX-targeted inhibition of TBK1 on colitis. We found that the severity of colitis in mice was correlated with TBK1 expression. Notably, although ALX inhibited the activation of the TBK1-NF-κB/TBK1-IRF3 pro-inflammatory signaling pathway, it exacerbated colitis and reduced survival in mice. The results of drug safety experiments ruled out a relationship between this exacerbating effect and drug toxicity. In addition, ELISA results showed that ALX promoted the secretion of IL-1β and IFN-α, and inhibited the production of cytokines IL-6, TNF-α, IL-10, TGF-β, and secretory IgA. Flow cytometry results further showed that ALX promoted T-cell proliferation, activation, and differentiation, and thus played a pro-inflammatory role; also, ALX inhibited the generation of dendritic cells and the polarization of macrophages to M1 type, thus exerting anti-inflammatory effect. These data suggest that the regulation of ALX on the function of different immune cells is different, so the effect on the inflammatory response is bidirectional. In conclusion, our study demonstrates that simply inhibiting TBK1 in all immune cells is not effective for the treatment of colitis. Further investigation of the anti-inflammatory mechanism of ALX on dendritic cells and macrophages may provide a new strategy for the treatment of IBD.
Assessing the effect of body mass index on perioperative outcomes and short-term recurrence after paraesophageal hernia repair
Authors: Han Shiwei , Qaraqe Taha , Hillenbrand Charles , Du Simo , Jenq Wesley , Kuppusamy MadhanKumar , Sternbach Joel , Hubka Michal , Low Donald E 
Published: September 2024

Summary
Previous assessments suggest that surgical results of paraesophageal hernia (PEH) repair were negatively impacted by increasing levels of obesity. A better understanding of the association of obesity on outcomes of PEH repair will support surgeons making evidence-based decisions on the surgical candidacy of individual patients. This single institution retrospective cohort study included 884 consecutive patients with giant PEH undergoing surgical repair between 1 January 2000 and 30 June 2020. Preoperative body mass index (BMI) was documented at the time of surgery. Main outcomes included perioperative blood loss, length of hospital stay, major complications, early hernia recurrence, and mortality. The mean (standard deviation [SD]) age at surgery was 68.4 (11.1), and 645 (73.0%) were women. Among the 884 patients, 875 had a documented immediate preoperative BMI and were included in the analysis. Mean (SD) BMI was 29.24 (4.91) kg/m2. Increasing BMI was not associated with increased perioperative blood loss (coefficient, 0.01; 95% confidence interval [CI], −0.01 to 0.02), prolonged length of stay (coefficient, −0.01; 95% CI, −0.02 to 0.01), increased incidence of recurrent hernia (odds ratio [OR], 1.03; 95% CI, 0.95–1.10), or increased major complications (OR, 0.93; 95% CI, 0.82–1.05). The 90-day mortality rate was 0.3%. Furthermore, when compared with the normal weight group, overweight and all levels of obesity were not related to unfavorable outcomes. No association was found between BMI and perioperative outcomes or short-term recurrence in patients undergoing PEH repair. Although preoperative weight loss is advisable, a higher BMI should not preclude or delay surgical management of giant PEH.
Determining the learning curve of minimally invasive antireflux surgery: systematic review, meta-analysis, and meta-regression
Authors: Sivakumar Jonathan , Chen Qianyu , Bull Nicholas , Hii Michael W , Al-Habbal Yahya , Duong Cuong Phu 
Published: September 2024

Summary
The rapid uptake of minimally invasive antireflux surgery has led to interest in learning curves for this procedure. This study ascertains the learning curve in laparoscopic and robotic-assisted antireflux surgery. A systematic review of the literature pertaining to learning curves in minimally invasive fundoplication with or without hiatal hernia repair was performed using PubMed, Medline, Embase, Web of Science, and Cochrane Library databases. A meta-regression analysis was undertaken to identify the number of cases to achieve surgical proficiency, and a meta-analysis was performed to compare outcomes between cases that were undertaken during a surgeon’s learning phase and experienced phase. Twenty-five studies met the eligibility criteria. A meta-regression analysis was performed to quantitatively investigate the trend of number of cases required to achieve surgical proficiency from 1996 to present day. Using a mixed-effects negative binomial regression model, the predicted learning curve for laparoscopic and robotic-assisted antireflux surgery was found to be 24.7 and 31.1 cases, respectively. The meta-analysis determined that surgeons in their learning phase may experience a moderately increased rate of conversion to open procedure (odds ratio [OR] 2.44, 95% confidence interval [CI] 1.28, 4.64), as well as a slightly increased rate of intraoperative complications (OR 1.60; 95% CI 1.08, 2.38), postoperative complications (OR 1.98; 95% CI 1.36, 2.87), and needing reintervention (OR 1.64; 95% CI 1.16, 2.34). This study provides an insight into the expected caseload to be competent in performing antireflux surgery. The discrepancy between outcomes during and after the learning curve for antireflux surgery suggests a need for close proctorship for learning surgeons.
Long-term efficacy of drug-coated balloon only angioplasty for IgG4-related coronary artery disease: a case report
Authors: Yamada Mayu , Ueno Katsumi , Kojima Yoshinobu , Watanabe Mitsuru , Morita Norihiko 
Published: September 2024

Abstract

Background
Although coronary artery involvement in patients with IgG4-related disease (IgG4-RD) is rare, emergency revascularization is recommended for managing acute coronary syndrome. However, coronary aneurysm formation and stent migration after sirolimus-eluting stent implantation have been reported for this disease. Thus, new treatment modalities are warranted for the management of coronary artery disease in this vasculitis.

Case summary
A 70-year-old male who experienced progressive chest discomfort for 1 month underwent cardiac examination. Coronary computed tomography angiography (CCTA) revealed right coronary artery hypoplasia, coronary artery aneurysm with severely calcified stenosis in the proximal left anterior descending artery (LAD), and subtotal obstruction in the mid-LAD. The left circumflex artery (LCX) also had stenosis and dilated lesions. Additionally, diffuse perivascular soft tissue thickening was observed in the mid-LCX. The percutaneous coronary intervention was performed for the proximal- and mid-LAD lesions. Rotational atherectomy with low-pressure drug-coated balloon (DCB) dilation was considered for these lesions owing to suspicion of vasculitis. The patient was later diagnosed with Sjögren’s syndrome and IgG4-RD overlap syndrome. Oral steroids and immunosuppressive drugs were initiated. In a follow-up at 7 and 26 months, late lumen enlargement was observed in the treated area of the LAD, without enlargement of the adjacent aneurysm. CCTA performed after 26 months revealed resolution of the diffuse perivascular soft tissue thickening in the mid-LCX.

Discussion
To our knowledge, this is the first case report demonstrating favourable outcomes for treatment of a coronary artery lesion attributed to IgG4-RD with DCB, leaving nothing implanted in the coronary artery tree.
Management of aortic disease in children with FBN1-related Marfan syndrome
Authors: Muiño-Mosquera Laura , Cervi Elena , De Groote Katya , Dewals Wendy , Fejzic Zina , Kazamia Kalliopi , Mathur Sujeev , Milleron Olivier , Mir Thomas S , Nielsen Dorte G , Odermarsky Michal , Sabate-Rotes Anna , van der Hulst Annelies , Valenzuela Irene , Jondeau Guillaume 
Published: September 2024

Abstract
Marfan syndrome (MFS) is a hereditary connective tissue disorder with an estimated prevalence of 1:5000–1:10 000 individuals. It is a pleiotropic disease characterized by specific ocular, cardiovascular, and skeletal features. The most common cardiovascular complication is aortic root dilatation which untreated can lead to life-threatening aortic root dissection, mainly occurring in adult patients. Prompt diagnosis, appropriate follow-up, and timely treatment can prevent aortic events. Currently there are no specific recommendations for treatment of children with MFS, and management is greatly based on adult guidelines. Furthermore, due to the scarcity of studies including children, there is a lack of uniform treatment across different centres. This consensus document aims at bridging these gaps of knowledge. This work is a joint collaboration between the paediatric subgroup of the European Network of Vascular Diseases (VASCERN, Heritable Thoracic Aortic Disease Working Group) and the Association for European Paediatric and Congenital Cardiology (AEPC). A group of experts from 12 different centres and 8 different countries participated in this effort. This document reviews four main subjects, namely, (i) imaging of the aorta at diagnosis and follow-up, (ii) recommendations on medical treatment, (iii) recommendations on surgical treatment, and (iv) recommendations on sport participation.
Web of venom: exploration of big data resources in animal toxin research
Authors: Zancolli Giulia , von Reumont Björn Marcus , Anderluh Gregor , Caliskan Figen , Chiusano Maria Luisa , Fröhlich Jacob , Hapeshi Evroula , Hempel Benjamin-Florian , Ikonomopoulou Maria P , Jungo Florence , Marchot Pascale , de Farias Tarcisio Mendes , Modica Maria Vittoria , Moran Yehu , Nalbantsoy Ayse , Procházka Jan , Tarallo Andrea , Tonello Fiorella , Vitorino Rui , Zammit Mark Lawrence , Antunes Agostinho 
Published: September 2024

Abstract
Research on animal venoms and their components spans multiple disciplines, including biology, biochemistry, bioinformatics, pharmacology, medicine, and more. Manipulating and analyzing the diverse array of data required for venom research can be challenging, and relevant tools and resources are often dispersed across different online platforms, making them less accessible to nonexperts. In this article, we address the multifaceted needs of the scientific community involved in venom and toxin-related research by identifying and discussing web resources, databases, and tools commonly used in this field. We have compiled these resources into a comprehensive table available on the VenomZone website (https://venomzone.expasy.org/10897). Furthermore, we highlight the challenges currently faced by researchers in accessing and using these resources and emphasize the importance of community-driven interdisciplinary approaches. We conclude by underscoring the significance of enhancing standards, promoting interoperability, and encouraging data and method sharing within the venom research community.
Copyright as an Access Right: Concretizing Positive Obligations for Rightholders to Ensure the Exercise of User Rights
Authors: Geiger Christophe , Jütte Bernd Justin 
Published: September 2024

Abstract
The legal frameworks that govern access to information are essential for safeguarding a sustainable, creative ecosystem. Institutions, such as libraries, research organizations, educational and other cultural heritage institutions, are gateways to diverse collections of scientific production, media and other cultural artefacts. Enabling access to creative works requires careful balancing of the interest of creators, producers of information, publishers and users of that information. While copyright law has traditionally recognized that rightholders enjoy exclusive rights, courts have only recently emphasized that users of works must also enjoy rights, which better reflects that copyright is based on a social contract with reciprocal obligations. This study explores what positive obligations must be imposed on rightholders as a consequence of the rights users enjoy under copyright law. Although specific access-enabling mechanisms already exist in EU copyright law, they are often not properly implemented or lack efficient enforcement tools. For that purpose, certain exceptions and limitations must be made mandatory, prohibitions on contractual override must apply horizontally, privileged institutions should enjoy enforceable rights to obtain copies on reasonable terms, and the existing ‘lending’ right must become a ‘right to lend’. Supporting these substantive changes is the proposal for a new governance structure for the EU copyright framework through the establishment of an independent EU regulatory body. It is only through a blend of changes that copyright can serve society and that a sound ecosystem for creators and creativity is set up making the EU fit for the knowledge economy.
Exploring genetic diversity, population structure, and subgenome differences in the allopolyploid Camelina sativa: implications for future breeding and research studies
Authors: Brock Jordan R , Bird Kevin A , Platts Adrian E , Gomez-Cano Fabio , Gupta Suresh Kumar , Palos Kyle , Railey Caylyn E , Teresi Scott J , Lee Yun Sun , Magallanes-Lundback Maria , Pawlowski Emily G , Nelson Andrew D L , Grotewold Erich , Edger Patrick P 
Published: September 2024

Abstract
Camelina (Camelina sativa), an allohexaploid species, is an emerging aviation biofuel crop that has been the focus of resurgent interest in recent decades. To guide future breeding and crop improvement efforts, the community requires a deeper comprehension of subgenome dominance, often noted in allopolyploid species, “alongside an understanding of the genetic diversity” and population structure of material present within breeding programs. We conducted population genetic analyses of a C. sativa diversity panel, leveraging a new genome, to estimate nucleotide diversity and population structure, and analyzed for patterns of subgenome expression dominance among different organs. Our analyses confirm that C. sativa has relatively low genetic diversity and show that the SG3 subgenome has substantially lower genetic diversity compared to the other two subgenomes. Despite the low genetic diversity, our analyses identified 13 distinct subpopulations including two distinct wild populations and others putatively representing founders in existing breeding populations. When analyzing for subgenome composition of long non-coding RNAs, which are known to play important roles in (a)biotic stress tolerance, we found that the SG3 subgenome contained significantly more lincRNAs compared to other subgenomes. Similarly, transcriptome analyses revealed that expression dominance of SG3 is not as strong as previously reported and may not be universal across all organ types. From a global analysis, SG3 “was only significant higher expressed” in flower, flower bud, and fruit organs, which is an important discovery given that the crop yield is associated with these organs. Collectively, these results will be valuable for guiding future breeding efforts in camelina.
Populism and foreign policy: India's refugee policy towards the Rohingya
Authors: Barthwal-Datta Monika , Singh Shweta 
Published: September 2024

Abstract
In this article, we investigate how India's refugee policy towards the Rohingya is implicated in the (re)production of the Bharatiya Janata Party's (BJP) populist project. We enhance an innovative contextual intersectional framework, drawing on Ernesto Laclau's conceptualization of populism as a political logic and build on Shweta Singh and Élise Féron's understanding of this populist logic as discursively co-constituted and based on varying intersecting identity constellations including race/ethnicity, religion, caste, class or gender/sexual orientation. Using this framework, we investigate how India's refugee policy towards Rohingya refugees in particular has evolved under successive populist governments led by the BJP. Analysing three key dimensions of India's refugee policy—legal framework, admission and status, and protection and security—we demonstrate significant shifts along these dimensions in India's refugee policy towards the Rohingya, and explicate the populist logic that is reinscribed through these changes at the site of ‘foreign policy’. Our analysis reveals these shifts as co-constituted in and through the populist logic of the BJP-led governments and relying on identity assemblages that emphasized the Rohingya's ethnicity/religion (Rohingya ‘Muslims’), gender/ sexual orientation (Rohingya ‘men’) and class (Rohingya in need of resources/ privileges). Our study opens up grounds for further research on how refugee policy, as a mode of foreign policy, becomes a site where populist governments reinscribe differences between the ‘people’ and dangerous enemy ‘others’ to (re)produce their populist political projects.
Role of HLA-B*58:01–Restricted CD8+ T Cells in HIV-1 Subtype AE Infection
Authors: Nguyen Hung The , Chikata Takayuki , Zhang Yu , Van Tran Giang , Gatanaga Hiroyuki , Oka Shinichi , Takiguchi Masafumi 
Published: September 2024

Abstract
HLA-B*58:01 and HLA-B*57 are protective alleles against human immunodeficiency virus type 1 (HIV-1) subtype B or C infection, whereas these HLA alleles have not been reported as protective in HIV-1 subtype AE infection. Although HLA-B*58:01–restricted and HLA-B*57–restricted HIV-1–specific CD8+ T cells have been thoroughly analyzed in subtype B or C infection, they have been only partially analyzed in subtype AE infection. We identified 6 HLA-B*58:01–restricted subtype AE epitopes in Vietnamese individuals infected with subtype AE. HLA-B*58:01–restricted T-cell responses to Gag epitopes, which may control disease progression in HLA-B*58:01+ and HLA-B*57+ individuals infected with subtype B or C, were not protective in subtype AE infection. These findings suggest that the loss of HLA-B*58:01–restricted T cells specific for some Gag epitopes and/or their reduced ability may account for the lack of protective effects conferred by HLA-B*58:01 in subtype AE infection.
Modeling long-term, stage-structured dynamics of Tribolium castaneum (Coleoptera: Tenebrionidae) at food facilities with and without two types of long-lasting insecticide-incorporated netting
Authors: Ranabhat Sabita , Gerken Alison R , Scheff Deanna S , Zhu Kun Yan , Morrison William R 
Published: September 2024

Abstract
The red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), is a cosmopolitan and destructive external-infesting pest at many food facilities. The use of deltamethrin- and α-cypermethrin-incorporated long-lasting insecticide-incorporated netting (LLIN) has shown incredible promise for the management of stored product insects. However, it is unknown how LLIN deployed within food facilities may affect the long-term population dynamics of T. castaneum compared to populations where no LLIN is present. Exposure to LLIN has been shown to affect mortality in the current generation and decrease progeny production in the subsequent generation. Thus, we modeled the long-term population dynamics of T. castaneum at food facilities over 15 generations by incorporating realistic estimates for mortality and progeny reduction after contact with LLIN compared to baseline growth by the species. We parameterized the model with estimates from the literature and used a four-stage structured population (eggs, larvae, pupae, and adults). The model was implemented using the package popbio in R. Our models suggest that deploying LLIN led to significant population reductions based on the estimates of mortality and progeny reduction from prior work, whereas the baseline model exhibited exponential population growth. In addition, there were differences in the frequencies of each life stage under each scenario modeled. As a result, it appears deploying LLIN may contribute to the local extirpation of T. castaneum within as few as 15 generations. Our work contributes to a growing literature about the effectiveness of incorporating LLIN into existing pest management programs for managing stored product insects in food facilities.
Reference genome of the kidnapper ant, Polyergus mexicanus
Authors: Cash Elizabeth I , Escalona Merly , Ward Philip S , Sahasrabudhe Ruta , Miller Courtney , Toffelmier Erin , Fairbairn Colin , Seligmann William , Shaffer H Bradley , Tsutsui Neil D 
Published: September 2024

Abstract
Polyergus kidnapper ants are widely distributed, but relatively uncommon, throughout the Holarctic, spanning an elevational range from sea level to over 3,000 m. These species are well known for their obligate social parasitism with various Formica ant species, which they kidnap in dramatic, highly coordinated raids. Kidnapped Formica larvae and pupae become integrated into the Polyergus colony where they develop into adults and perform nearly all of the necessary colony tasks for the benefit of their captors. In California, Polyergus mexicanus is the most widely distributed Polyergus, but recent evidence has identified substantial genetic polymorphism within this species, including genetically divergent lineages associated with the use of different Formica host species. Given its unique behavior and genetic diversity, P. mexicanus plays a critical role in maintaining ecosystem balance by influencing the population dynamics and genetic diversity of its host ant species, Formica, highlighting its conservation value and importance in the context of biodiversity preservation. Here, we present a high-quality genome assembly of P. mexicanus from a sample collected in Plumas County, CA, United States, in the foothills of the central Sierra Nevada. This genome assembly consists of 364 scaffolds spanning 252.31 Mb, with contig N50 of 481,250 kb, scaffold N50 of 10.36 Mb, and Benchmarking Universal Single-Copy Orthologs (BUSCO) completeness of 95.4%. We also assembled the genome of the Wolbachia endosymbiont of P. mexicanus—a single, circular contig spanning 1.23 Mb. These genome sequences provide essential resources for future studies of conservation genetics, population genetics, speciation, and behavioral ecology in this charismatic social insect.
Strolling to Nothingness: Japanese tea gardens and the initiation of Bildung
Authors: Kenklies Karsten 
Published: September 2024

Abstract
Although the alienating journey into the unknown as the fundamental element of transformative education may have gained a paradigmatic expression in the German concept of Bildungsreise, it is neither a solely German or even European concept, nor is it a child of the 18th century: the transformative power of travelling has been acknowledged at least since antiquity in Europe, and comparable reflections and practices have evolved in other parts of the world. This article will introduce one of those examples that may, only on first view though, look quite distinct from what is suggested as Bildungsreise: the strolling on the roji (露地), the path through the tea garden, before entering the chashitsu (茶室), the tea room, to participate in chanoyu (茶の湯), the tea ceremony, as it found its classic form in 16th-century Japan. Discussing this Japanese practice will not only support an intercultural perspective on the educative nature of travel and the relevance of space for the theory and practice of transformative education or Bildung, but also—more relevant from a philosophical point of view—enable an analysis of the conceptual core of the idea of a transformative journey. As will be shown, far from being a special case of education or Bildung, this conceptual structure lies at the very heart of both.