bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obinutuzumab or Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Previously Untreated Diffuse Large B-Cell Lymphoma
Authors: Vitolo Umberto , Trněný Marek , Belada David , Burke John M. , Carella Angelo Michele , Chua Neil , Abrisqueta Pau , Demeter Judit , Flinn Ian , Hong Xiaonan , Kim Won Seog , Pinto Antonio , Shi Yuan-Kai , Tatsumi Yoichi , Oestergaard Mikkel Z. , Wenger Michael , Fingerle-Rowson Günter , Catalani Olivier , Nielsen Tina , Martelli Maurizio , Sehn Laurie H. 
Published: August 2017

Purpose Rituximab (R) plus CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy is the standard of care in previously untreated diffuse large B-cell lymphoma (DLBCL). Obinutuzumab (G) is a glycoengineered, type II, anti-CD20 monoclonal antibody. GOYA was a randomized phase III study that compared G-CHOP with R-CHOP in patients with previously untreated advanced-stage DLBCL. Methods Patients (N = 1,418) were randomly assigned to receive eight 21-day cycles of G (n = 706) or R (n = 712), plus six or eight cycles of CHOP. Primary end point was investigator-assessed progression-free survival (PFS). Results After median observation of 29 months, the number of investigator-assessed PFS events was similar between G (201; 28.5%) and R (215; 30.2%), stratified hazard ratio was 0.92 (95% CI, 0.76 to 1.11; P = .39), and 3-year PFS rates were 70% and 67%, respectively. Secondary end points of independently reviewed PFS, other time-to-event end points, and tumor response rates were similar between arms. In exploratory subgroup analyses, patients with germinal-center B cell–like subtype had a better PFS than did patients with activated B cell–like subtype, irrespective of treatment. Frequencies of grade 3 to 5 adverse events (AEs; 73.7% v 64.7%, respectively) and serious AEs (42.6% v 37.6%, respectively) were higher with G-CHOP compared with R-CHOP. Fatal AE frequencies were 5.8% for G-CHOP and 4.3% for R-CHOP. The most common AEs were neutropenia (G-CHOP, 48.3%; R-CHOP, 40.7%), infusion-related reactions (G-CHOP, 36.1%; R-CHOP, 23.5%), nausea (G-CHOP, 29.4%; R-CHOP, 28.3%), and constipation (G-CHOP, 23.4%; R-CHOP, 24.5%). Conclusion G-CHOP did not improve PFS compared with R-CHOP in patients with previously untreated DLBCL. AEs reported with G were consistent with the known safety profile. Biomarker analyses may help define a future role for G in DLBCL.
Control mechanisms in germ cells mediated by p53 family proteins
Authors: Gebel Jakob , Tuppi Marcel , Krauskopf Katharina , Coutandin Daniel , Pitzius Susanne , Kehrloesser Sebastian , Osterburg Christian , Dötsch Volker 
Published: August 2017

ABSTRACT
Germ cells are totipotent and, in principle, immortal as they are the source for new germ cells in each generation. This very special role requires tight quality control systems. The p53 protein family constitutes one of the most important quality surveillance systems in cells. Whereas p53 has become famous for its role as the guardian of the genome in its function as the most important somatic tumor suppressor, p63 has been nicknamed ‘guardian of the female germ line’. p63 is strongly expressed in resting oocytes and responsible for eliminating those that carry DNA double-strand breaks. The third family member, p73, acts later during oocyte and embryo development by ensuring correct assembly of the spindle assembly checkpoint. In addition to its role in the female germ line, p73 regulates cell-cell contacts between developing sperm cells and supporting somatic cells in the male germ line. Here, we review the involvement of the p53 protein family in the development of germ cells with a focus on quality control in the female germ line and discuss medical implications for cancer patients.
Polyp bailout in Pocillopora damicornis following thermal stress
Authors: Fordyce Alexander J , Camp Emma F , Ainsworth Tracy D 
Published: August 2017

Polyp bailout is an established but understudied coral stress response that involves the detachment of individual polyps from the colonial form as a means of escaping unfavourable conditions. This may influence both the mortality and asexual recruitment of coral genotypes across a range of species. It has been observed in response to numerous stressors including high salinity and low pH. Polyp expulsion in association with thermal stress has once been described in a geographically restricted, temperate species. We therefore cannot reliably apply this observation to tropical coral reefs around the world, which are increasingly under threat from thermal stress events. We present the first qualitative observation of polyp bailout following acute temperature shock in a near-natural mesocosm experiment. Detached polyps show similar characteristics to those described in previous studies, including the retention of endosymbiotic zooxanthellae and the ability to disperse across short distances. This finding strongly suggests that polyp bailout occurs in tropical coral reef environments and warrants further detailed research into the implication of this response in terms of individual survival, rapid migration into cooler micro-habitats and local recruitment within the reef environment and its coral community.
Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
Authors: Howard David M. , Adams Mark J. , Clarke Toni-Kim , Wigmore Eleanor M. , Zeng Yanni , Hagenaars Saskia P. , Lyall Donald M. , Thomson Pippa A. , Evans Kathryn L. , Porteous David J. , Nagy Reka , Hayward Caroline , Haley Chris S. , Smith Blair H. , Murray Alison D. , Batty G. David , Deary Ian J. , McIntosh Andrew M. 
Published: August 2017

Background:Cognitive ability is a heritable trait with a polygenic architecture, for which several associated variants have been identified using genotype-based and candidate gene approaches. Haplotype-based analyses are a complementary technique that take phased genotype data into account, and potentially provide greater statistical power to detect lower frequency variants.Methods:In the present analysis, three cohort studies (ntotal= 48,002) were utilised: Generation Scotland: Scottish Family Health Study (GS:SFHS), the English Longitudinal Study of Ageing (ELSA), and the UK Biobank. A genome-wide haplotype-based meta-analysis of cognitive ability was performed, as well as a targeted meta-analysis of several gene coding regions.Results:None of the assessed haplotypes provided evidence of a statistically significant association with cognitive ability in either the individual cohorts or the meta-analysis. Within the meta-analysis, the haplotype with the lowest observedP-value overlapped with the D-amino acid oxidase activator (DAOA) gene coding region. This coding region has previously been associated with bipolar disorder, schizophrenia and Alzheimer’s disease, which have all been shown to impact upon cognitive ability. Another potentially interesting region highlighted within the current genome-wide association analysis (GS:SFHS:P= 4.09 x 10-7), was the butyrylcholinesterase (BCHE) gene coding region. The protein encoded byBCHEhas been shown to influence the progression of Alzheimer’s disease and its role in cognitive ability merits further investigation.Conclusions:Although no evidence was found for any haplotypes with a statistically significant association with cognitive ability, our results did provide further evidence that the genetic variants contributing to the variance of cognitive ability are likely to be of small effect.
The Competitive Dynamics of New DVD Releases
Authors: Mukherjee Anirban , Kadiyali Vrinda 
Published: August 2017

We study the market for new (movie) DVDs in the United States. Our demand model captures seasonality, freshness (i.e., time between theatrical and DVD release), and state dependence. We also develop a structural model of dynamic competition in which studios balance waiting for high-demand weeks, against reduced freshness, and against competitive crowding. We find that studios emphasize DVD revenues from larger movies (by theatrical revenue) over DVD revenues from smaller movies. Studios also emphasize revenue from consumers who prefer larger and fresher movies. These behaviors are consistent with managerial conservatism: studio executives forgo DVD revenues from smaller movies to ensure the DVD success of larger movies. This paper was accepted by J. Miguel Villas-Boas, marketing.
DESARROLLO E IMPLEMENTACIÓN DE FOTOCONTROL TEMPORIZADO CON TECNOLOGÍA DE BAJO CONSUMO
Authors: Martínez Sarmiento Fredy Hernán , Jacinto Gómez Edward , Ramírez Buitrago David 
Published: August 2017

En este trabajo se presenta el desarrollo e implementación de un fotocontrol con tecnología de bajo consumo desarrollado con un microcontrolador, el cual controla variables de tensión, luminosidad y sincronización con la red, por medio de una salida con modo PWM producir una salida de Vdc en el relé. El microcontrolador realiza un muestreo análogo de voltaje sobre la onda sinusoidal y se hace un filtro de promedio móvil para eliminar ruido de la onda.La temporización se realiza cuando el contacto del relé está cerrado y el tiempo a temporizar es programado por el usuario el cual lo requiera, el fotocontrol presenta un modo de ultra bajo consumo en el microcontrolador con un supercap.
CREACIÓN DE UN METAVERSO EN OPENSIM PARA LA UNIVERSIDAD DISTRITAL DENTRO DE LA RED RITA-UD
Authors: Torres Vallejo Nicolás , Uribe Sierra Edward Johannes , Ferro Escobar Roberto 
Published: August 2017

Este paper contempla el montaje de un segmento de red inalámbrico para la red RITA-UD con el fin de brindar acceso a contenidos multimedia a través de un mundo virtual creado en OPENSIM. Los contenidos de las emisiones de streaming se encuentran almacenados en un servidor ubicado en el centro de computación de alto desempeño, CECAD. Al tiempo que se realizaron pruebas de streaming multicast, se capturaron dichas transmisiones mediante el sniffer de paquetes WireShark con el fin de determinar parámetros de QoS que caractericen el canal.
Nazwy komitetów wyborczych – aspekty strukturalne i aksjologiczne
Authors: Naruszewicz-Duchlińska Alina 
Published: August 2017

The subject of this paper will be a semantic and structural analysis of the names of electoral committees, and a reference to the axiological systems that are indirectly reflected by them. The names of electoral committees are obligatory elements of electoral activities, as well as being an interesting element of political marketing.
In-silico screening of 2,3-diphenylquinozaline derivatives as C-met kinase inhibitors
Authors: Yahcoob Nehla , Lakshmanan Baskar , Achuthanandhan Jyothi , Balakrishnan Vijayakumar 
Published: August 2017

Quinoxaline, an important class of heterocylic compounds drawn greater attention due to their wide spectrum of biological activities. They are considered as an important chemical scaffold for anticancer drug designÂ due to their potential inhibitory activity againstÂ C-met tyrosine kinase. C-met kinase inhibitorsÂ are a class ofÂ small molecules that having therapeutic potential inÂ the treatment of various types of cancers. The present study aims to focus on the chemistry of quinoxaline derivatives, their potential activities against C-met tyrosine kinase, and in-silico screening of designed compounds. A series of twelve compounds were designed and docked against C-met tyrosine kinase for their binding energy. All compounds were found to be interactingÂ well with the protein. Compound NQ1 was found to have good binding energy showing an estimated Ki value ofÂ 1.1Î¼m.Â SARÂ study indicated the presence of an electron withdrawing substitution onÂ benzilidineÂ phenyl ring of quinoxaline greatly improves its binding interaction with the protein.
Two-Legged Stool: New Findings from California on Nonprofits and Overhead
Authors: Berlin Nancy , Masaoka Jan , Schumann Mary Jo 
Published: August 2017

AbstractNonprofit overhead is a prevalent and controversial topic in the nonprofit and philanthropic sector. Online raters (such as Charity Navigator) point to the overhead rate as a key indicator of nonprofit worthiness. Different government entities use wildly different indirect cost rates when contracting with nonprofits, which translate into billions of dollars of funding being gained or lost. Foundations rarely have explicit guidelines, but most have informal rules of thumb that affect how a nonprofit can use grant funds. Meanwhile, nonprofit executives struggle to make sense of it all as they manage their operations amidst the conflicting requirements of their funding sources. To gain insights into how overhead costs are handled in nonprofits, the California Association of Nonprofits (CalNonprofits) conducted a survey of 451 California nonprofit executives, as well as interviews with elected members of county boards of supervisors and their staff throughout California in the spring of 2016. This paper reports on both of these, which were part of a larger initiative of CalNonprofits called The Nonprofit Overhead Project.
Sport-Specific Repeated Sprint Training Improves Punching Ability and Upper-Body Aerobic Power in Experienced Amateur Boxers
Authors: Kamandulis Sigitas , Bruzas Vidas , Mockus Pranas , Stasiulis Arvydas , Snieckus Audrius , Venckunas Tomas 
Published: August 2017

Abstract
Kamandulis, S, Bruzas, V, Mockus, P, Stasiulis, A, Snieckus, A, and Venckunas, T. Sport-specific repeated sprint training improves punching ability and upper-body aerobic power in experienced amateur boxers. J Strength Cond Res 32(5): 1214–1221, 2018—High-intensity interval training improves endurance and performance, but it is unclear whether sprint-type upper-body interval training is similarly effective. This study explored the effects of 4-week sport-specific sprint interval training on punch characteristics and endurance capacity in boxers. Experienced male amateur boxers (n = 18) participated in this 4-week training study and were divided into an experimental group (EG) and a control group (CG) (n = 9 per group). Both groups completed standard low-intensity training. The EG also completed 3 rounds (14 sets of 3-second all-out punching with a 10-second rest) of a simulated fight using a punching bag with a 1-minute rest between rounds 3 times per week, whereas the CG performed the same 3 rounds of a simulated fight at low intensity. Three rounds of 14 sets of 3-second all-out punching of a bag ergometer with a 10-second rest were performed to measure punching abilities. Peak oxygen consumption and peak power were measured during progressive arm cranking before and after training. In response to training peak oxygen consumption and peak power in arm-cranking test increased in EG, also punching force increased and maintenance of punching frequency and punch force improved during the simulated fight, which resulted in greater cumulative force throughout the 3 rounds. There were no changes in the CG. The study shows that 1 month of all-out punching training (3 sessions per week with ∼2 minutes of all-out punching per session) improved both upper-body aerobic power and punching abilities in experienced amateur boxers.
The Effects of British Army Footwear on Ground Reaction Force and Temporal Parameters of British Army Foot Drill
Authors: Rawcliffe Alex J. , Graham Scott M. , Simpson Richard J. , Moir Gavin L. , Martindale Russell J.J. , Psycharakis Stelios G. , Connaboy Chris 
Published: August 2017

Abstract
Rawcliffe, AJ, Graham, SM, Simpson, RJ, Moir, GL, Martindale, RJ, Psycharakis, SG, and Connaboy, C. The effects of British Army footwear on ground reaction force and temporal parameters of British Army foot drill. J Strength Cond Res 34(3): 754–762, 2020—High rates of occupational training-related lower-limb musculoskeletal (MSK) overuse injuries are reported for British Army recruits during basic training. Foot drill is a repetitive impact loading occupational activity and involves striking the ground violently with an extended-knee (straight-leg) landing. Foot drill produces vertical ground reaction force (vGRF) equal to or greater than those reported for high-level plyometric exercises/activities. Shock absorbing footwear aid in the attenuation of the magnitude of vGRF, resulting in a reduced risk of lower-limb MSK overuse injury when running. The potential shock absorbing characteristics of standard issue British Army footwear on the magnitude of vGRF and temporal parameters of foot drill are scant. Therefore, this study sought to determine the magnitude of and examine changes in vGRF and temporal parameters of foot drill across 3 types of British Army footwear. Sampled at 1,000 Hz, the mean of 8 trials from 15 recreationally active men were collected from 4 foot drills; stand-at-ease, stand-at-attention, quick-march (QM), and halt. Analysis of a normal walk was included to act as a comparison with QM. Significant main effects (P ≤ 0.05) were observed between footwear and foot drill. The training shoe (TR) demonstrated significantly greater shock absorbing capabilities when compared with the combat boot and ammunition boot. Foot drill produced peak vGRF and peak vertical rate of force development in excess of 5 bw, and 350 bw·s−1, respectively. Time to peak vGRF ranged from 0.016 to 0.036 ms across foot drills, indicating that passive vGRF may not be under neuromuscular control. The marginal reductions in the magnitude of vGRF and temporal parameters in foot drill associated with the TR may act to reduce the accumulative impact loading forces experienced by recruits, subsequently minimizing the severity and rates of lower-limb MSK overuse injuries and recruit medical discharges during basic training.
Las “Fiestas de la Paz”. Ritualidad, cesarismo y modernidad en México en el arranque del siglo xx
Authors: Pérez Lara Campos 
Published: August 2017

Este artículo analiza las “Fiestas de la Paz” celebradas en la ciudad de México entre el 1 y el 4 de diciembre de 1900, tanto desde el punto de vista ritual como discursivo. El objetivo de este análisis es, por una parte, mostrar el giro cesarista de la política de Porfirio Díaz en sus últimos años de gobierno, a partir de su construcción ritual; y, por otra, reflexionar sobre qué significado se le asignó oficialmente a la idea de la paz y qué papel jugó ésta en la construcción del carisma del General Díaz.
This article analyzes the “Fiestas de la Paz,” celebrated in Mexico City from December 1 to 4, 1900, from a ritual as well as a discursive point of view. The objective of this article is twofold: on the one hand, to show how the ritual construction of Porfirio Díaz’s politics during the last years of his government enabled those politics to take on a Caesarist bent; on the other hand, to reflect on the meaning officially assigned to the idea of peace and on the role this assignation played in the construction of General Díaz’s charisma.
Knights and Caballeros
Authors: Young Julia G. 
Published: August 2017

This article reconstructs and analyzes the role of the Knights of Columbus in Mexico’s Cristero War. Founded in Connecticut in 1882, the Order quickly expanded into Mexico, establishing its first chapters there in 1905. Within two decades, the Mexican Caballeros de Colón had become one of the country’s most prominent and politically active Catholic lay organizations. During the Cristero War (1926–1929), the Mexican and U.S. Knights collaborated in order to resist the anticlerical Mexican state. In the process, the organization connected and politicized Catholics who supported the Cristero cause. By tracing the expansion of the Knights of Columbus from the United States into Mexico, and then following the Mexican Knights back into exile in the United States, this article demonstrates how transnational political activism shaped the lives of Catholics on both sides of the border.
Este artículo reconstruye y analiza el papel que jugó la orden llamada Knights of Columbus en la Guerra Cristera de México. Fundada en Connecticut en 1882, dicha orden se expandió rápidamente a México y estableció sus primeros capítulos ahí en 1905. En el lapso de dos décadas, los “Caballeros de Colón” mexicanos se convirtieron en una de las organizaciones católicas laicas más prominentes y con mayor actividad política del país. Durante la Guerra Cristera (1926–1929), los Caballeros mexicanos y estadounidenses colaboraron con el fin de resistir al Estado mexicano anticlerical. En este proceso, la organización conectó y politizó a los católicos que apoyaban la causa cristera. Al rastrear la expansión de los Caballeros de Colón de los Estados Unidos a México y al seguir sus pasos de regreso al exilio en Estados Unidos, este artículo demuestra cómo el activismo político transnacional conformó las vidas de los católicos a ambos lados de la frontera.
Lo queer de Carlos Monsiváis
Authors: Holcombe William Daniel 
Published: August 2017

Este trabajo analiza la utilización del vocablo queer en los análisis socioculturales del cronista mexicano Carlos Monsiváis. Mientras que en Estados Unidos y Europa lo queer se convierte en teoría deconstructivista, en México Monsiváis (erudito por excelencia de los estudios sobre la sexualidad) emplea dicho término para estudiar la feminidad de algunos homosexuales en el ambiente gay. Dado que Monsiváis jamás pretende ser un académico o teórico queer, el término le sirve como herramienta para revelar la feminización de la imagen nacional mexicana y los discursos machistas mexicanos que se oponen a ella. El presente trabajo estudia los niveles sociales y las geografías queer como referentes que Monsiváis utiliza para manejar este concepto.
This essay analyzes how Mexican chronicler Carlos Monsiváis wields the term queer in his sociocultural analyses. Whereas in the United States and Europe queer is transformed into a deconstructivist theory, Monsiváis (expert par excellence within Mexican sexual studies) uses the term to study feminized homosexuals in gay environments. Since Monsiváis never claims to be a queer academic or theoretician, the term serves as a tool to reveal the feminization of the Mexican national image within Mexican male chauvinist discourses. This essay analyzes social status and queer geographies as framing referents that define how Monsiváis utilizes queer conceptually.
Detección de crinivirus y begomovirus en plántulas de tomate y arvenses asociadas a semilleros
Authors: Solórzano Morales Ántony , Castro Vásquez Ruth , Barboza Vargas Natalia , Hernández Jiménez Eduardo , W. Hammond Rosemarie , Ramírez Fonseca Pilar 
Published: August 2017

The aim of this work was to detect plant infections caused by Tomato chlorosis virus (ToCV) and begomovirus in tomato plantlets, and in growing weeds around nursery greenhouses. During one year, starting in April 2008, 168 leaf tissue samples were collected, 90 tomato plantlets and 78 weeds from three different nurseries in Cartago province, Costa Rica. Reverse transcription and real time polymerase chain reaction (qRT-PCR) was used to determine that 18,9% of tomato plantlets and 7,7% of weeds were infected with ToCV virus. Begomoviruses were detected using Dot Blot hybridization and non-radioactive probe. Next, hybridization results were confirmed using Rolling Circle Amplification (RCA) followed by PCR, using universal primers. None tomato plantlet resulted positive when tested, but there were six weeds infected; in fact, Phytolacca icosandra and Brassica sp. were both coinfected with ToCV virus. These results suggest that ToCV infected tomato plantlets when commercialized, could serve as way of virus introduction to other country regions. Finally, weeds growing around greenhouses have shown to be potential viral sources of ToCV and begomovirus.