bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIV‐free survival at 12–24 months in breastfed infants of HIV‐infected women on antiretroviral treatment
Authors: Chikhungu Lana Clara , Bispo Stephanie , Rollins Nigel , Siegfried Nandi , Newell Marie‐Louise 
Published: April 2016

AbstractObjectiveTo provide estimates of HIV‐free survival at 12–24 months in breastfed children by maternal ART (6 months or lifelong) to inform WHO HIV and Infant Feeding guidelines.MethodsEighteen studies published 2005–2015 were included in a systematic literature review (1295 papers identified, 156 abstracts screened, 55 full texts); papers were analysed by narrative synthesis and meta‐analysis of HIV‐free survival by maternal ART regimen in a random effects model. We also grouped studies by feeding modality. Study quality was assessed using a modified Newcastle–Ottawa Scale (NOS) and GRADE.ResultsThe pooled estimates for 12‐month HIV‐free survival were 89.8% (95% confidence interval, CI: 86.5%, 93.2%) for infants of mothers on ART for 6 months post‐natally (six studies) and 91.4% (95% CI 87.5%, 95.4%) for infants of mothers on lifelong ART (three studies). Eighteen‐month HIV‐free survival estimates were 89.0% (95% CI 83.9%, 94.2%) with 6 months ART (five studies) and 96.1% (95% CI 92.8%, 99.0%) with lifelong ART (three studies). Twenty‐four‐month HIV‐free survival for infants whose mothers were on ART to 6 months post‐natally (two studies) was 89.2% (95% CI 79.9%, 98.5%). Heterogeneity was considerable throughout. In four studies, HIV‐free survival in breastfed infants ranged from 87% (95% CI 78%, 92%) to 96% (95% CI 91%, 98%) and in formula‐fed infants from 67% (95% CI 35.5%, 87.9%) to 97.6% (95% CI 93.0%, 98.2%).ConclusionOur results highlight the importance of breastfeeding for infant survival and of ART in reducing the risk of mother‐to‐child HIV transmission and support the WHO recommendation to initiate ART for life immediately after HIV diagnosis.
Ureteral Papilla Implantation as a Technique for Neoureterocystostomy in Cats Undergoing Renal Transplantation: 30 Cases
Authors: Sutherland Brian J. , McAnulty Jonathan F. , Hardie Robert J. 
Published: April 2016

ObjectiveTo describe the clinical outcome of donor and recipient cats undergoing ureteral papilla harvest and implantation as a technique for neoureterocystostomy in clinical kidney transplant.Study DesignRetrospective case series.AnimalsDonor (n=31) and recipient (n=30) cats that underwent kidney harvest and transplantation using ureteral papilla implantation technique for neoureterocystostomy.MethodsMedical records for donor and recipient cats presented to the University of Wisconsin Veterinary Teaching Hospital from January 2003 to December 2014 were reviewed. Data recorded included complete blood count, serum chemistry panel, surgical technique, diagnostic imaging results, short‐ and long‐term complications, and anesthetic survival.ResultsAll 30 recipients recovered from anesthesia. Four died within 24 hours and 26 survived to hospital discharge. Serum creatinine was within the reference interval by 72 hours in 22/26 cats (85%). Complications related to the ureteral papilla implantation technique were seen in only 1 cat (3%). Uroabdomen diagnosed on day 3 ultimately resolved over the following 24 hours without surgical intervention. All 31 donor cats survived to discharge. Four donors (13%) experienced mild, transiently increased serum creatinine.ConclusionUreteral papilla implantation is a viable technique for neoureterocystostomy in cats undergoing kidney transplantation. Proposed benefits for the recipient include a less technically challenging anastomosis, decreased risk of ureteral obstruction at the anastomosis site, and reduced risk of leakage compared to previous reports. Benefits for recipients should be weighed against risks to donors, including a more complex ureteral harvest, increased surgical time, and potential injury or obstruction of the contralateral ureteral papilla.
Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics
Authors: Shivkumar Kalyanam , Ajijola Olujimi A. , Anand Inder , Armour J. Andrew , Chen Peng‐Sheng , Esler Murray , De Ferrari Gaetano M. , Fishbein Michael C. , Goldberger Jeffrey J. , Harper Ronald M. , Joyner Michael J. , Khalsa Sahib S. , Kumar Rajesh , Lane Richard , Mahajan Aman , Po Sunny , Schwartz Peter J. , Somers Virend K. , Valderrabano Miguel , Vaseghi Marmar , Zipes Douglas P. 
Published: April 2016

AbstractThe autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.
Association between autism symptoms and functioning in children with ADHD
Authors: Green Jessica Leigh , Sciberras Emma , Anderson Vicki , Efron Daryl , Rinehart Nicole 
Published: April 2016

ObjectiveTo examine the association between autism spectrum disorder (ASD) symptoms and (a) social functioning, (b) mental health, (c) quality of life and (d) sleep in children with and without attention-deficit hyperactivity disorder (ADHD).MethodsParticipants were 6–10-year-old children with ADHD (N=164) and without ADHD (N=198). ADHD was assessed via community-based screening (wave 1) and case confirmation using the Diagnostic Interview Schedule for Children IV (DISC-IV) (wave 2). ASD symptoms were identified using the Social Communication Questionnaire (SCQ). Outcome measures were social functioning (Strengths and Difficulties Questionnaire (SDQ)), mental health (DISC-IV, SDQ), quality of life (QoL, Pediatric Quality of Life Inventory 4.0) and sleep problem severity.ResultsGreater ASD symptoms were associated with more parent and teacher-reported peer problems and emotional and conduct problems. For every SD increase in SCQ scores, internalising (OR 1.8, 95% CI 1.3 to 2.6, p=0.001) and externalising disorders (OR 1.5, 95% CI 1.1 to 2.1, p=0.02) increased, QoL decreased by 6.7 units (p<0.001), and moderate/severe sleep problems increased (OR 1.5, 95% CI 1.0 to 2.2, p=0.04). Most findings held in analyses adjusting for socio-demographic factors, ADHD symptom severity and comorbidities (when not the outcome), with the exception of externalising disorders and sleep problems.ConclusionsASD symptoms are associated with poorer functioning in children with ADHD. It is important to identify and potentially manage ASD symptoms in children with ADHD given that they exacerbate functional impairments in this already vulnerable group.
Prospective observational study protocol to investigate long-term adverse effects of methylphenidate in children and adolescents with ADHD: the Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) study
Authors: Inglis S K , Carucci S , Garas P , Häge A , Banaschewski T , Buitelaar J K , Dittmann R W , Falissard B , Hollis C , Kovshoff H , Liddle E , McCarthy S , Nagy P , Neubert A , Rosenthal E , Sonuga-Barke E , Wong I , Zuddas A , Coghill D C 
Published: April 2016

IntroductionMethylphenidate is the most frequently used medication for the treatment of attention-deficit/hyperactivity disorder (ADHD) in Europe. Following concerns about its safety, the European Commission called for research into the long-term effects of methylphenidate on children and adolescents with ADHD. The Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) research programme was designed to address this call. At the heart of this programme is a 2-year longitudinal naturalistic pharmacovigilance study being conducted in 27 European sites.Methods and analysis3 cohorts of children and adolescents (aged 6–17) living in the UK, Germany, Italy and Hungary are being recruited:Group 1 (Medicated ADHD): 800 ADHD medication-naive children and adolescents with a clinical diagnosis of ADHD about to start methylphenidate treatment for the first time.Group 2 (Unmedicated ADHD): 400 children and adolescents with a clinical diagnosis of ADHD who have never been treated with ADHD medication and have no intention of beginning medication.Group 3 (Non-ADHD): 400 children and adolescents without ADHD who are siblings of individuals in either group 1 or 2.All participants will be assessed 5 times during their 2-year follow-up period for growth and development, psychiatric, neurological and cardiovascular health. The primary outcome measure will be the height velocity SD score.Ethics and disseminationEthical approval for the study has been granted by the East of Scotland Research Ethics Service. Following this approval, patient information leaflets and consent forms were translated as necessary and submissions made by lead sites in each of the other 3 countries to their own ethics committees. Following ethical approval in each country, local ethical permissions at each site were sought and obtained as needed. The study's website (http://www.adhd-adduce.org/page/view/2/Home) provides information for researchers, participants and the general public.Trial registration numberNCT01470261.
Conflicts of interest and spin in reviews of psychological therapies: a systematic review
Authors: Lieb Klaus , Osten-Sacken Jan von der , Stoffers-Winterling Jutta , Reiss Neele , Barth Jürgen 
Published: April 2016

ObjectiveTo explore conflicts of interest (COI) and their reporting in systematic reviews of psychological therapies, and to evaluate spin in the conclusions of the reviews.MethodsMEDLINE and PsycINFO databases were searched for systematic reviews published between 2010 and 2013 that assessed effects of psychological therapies for anxiety, depressive or personality disorders, and included at least one randomised controlled trial. Required COI disclosure by journal, disclosed COI by review authors, and the inclusion of own primary studies by review authors were extracted. Researcher allegiance, that is, that researchers concluded favourably about the interventions they have studied, as well as spin, that is, differences between results and conclusions of the reviews, were rated by 2 independent raters.Results936 references were retrieved, 95 reviews fulfilled eligibility criteria. 59 compared psychological therapies with other forms of psychological therapies, and 36 psychological therapies with pharmacological interventions. Financial, non-financial, and personal COI were disclosed in 22, 4 and 1 review, respectively. 2 of 86 own primary studies of review authors included in 34 reviews were disclosed by review authors. In 15 of the reviews, authors showed an allegiance effect to the evaluated psychological therapy that was never disclosed. Spin in review conclusions was found in 27 of 95 reviews. Reviews with a conclusion in favour of psychological therapies (vs pharmacological interventions) were at high risk for a spin in conclusions (OR=8.31 (1.41 to 49.05)). Spin was related in trend to the inclusion of own primary studies in the systematic review (OR=2.08 (CI 0.83 to 5.18) p=0.11) and researcher allegiance (OR=2.63 (0.84 to 8.16) p=0.16).ConclusionsNon-financial COI, especially the inclusion of own primary studies into reviews and researcher allegiance, are frequently seen in systematic reviews of psychological therapies and need more transparency and better management.
Low red: Far-red light ratio causes faster in vitro flowering in lentil
Authors: Mobini Saeid H. , Lulsdorf Monika , Warkentin Thomas D. , Vandenberg Albert 
Published: April 2016

Artificial light in growth chambers typically has a higher red to far-red (R:FR) ratio compared with natural light. This higher ratio may delay flowering and reduce plant height in some long-day plants. Modification of light spectral quality to lower than the critical threshold of R:FR for a given plant species can have important implications with respect to plant structural and physiological traits. The objective of this study was to accelerate lentil (Lens culinaris) flower induction in growth chambers re-fitted with T5 fluorescent bulbs, using supplemental FR bulbs to re-balance the R:FR ratio. Lentil cultivars CDC Greenland and CDC Maxim were grown under three light sources differing in R:FR, namely light emitting diodes (LED; R:FR = 3.09), T5 fluorescent bulbs (R:FR = 5.6), and T5 supplemented with near far-red bulbs (R:FR = 3.1). All three light sources provided 500 µmol m−2 s−1 of photosynthetic photon flux (PPF). Lentil floral induction was significantly affected by the R:FR ratio. Plants grown under R:FR ratios of 3.1 or less flowered 10–11 d earlier than plants grown under an R:FR ratio of 5.6. Both cultivars had the same response to R:FR ratio in terms of days to flowering and flowering rate.
An Efficient Fast-Mapping SLAM Method for UAS Applications Using Only Range Measurements
Authors: Torres-González A. , Martinez-de Dios J. R. , Jiménez-Cano A. , Ollero A. 
Published: April 2016

This paper deals with 3D Simultaneous Localization and Mapping (SLAM), where the UAS uses only range measurements to build a local map of an unknown environment and to self-localize in that map. In the recent years Range Only (RO) SLAM has attracted significant interest, it is suitable for non line-of-sight conditions and bad lighting, being superior to visual SLAM in some problems. However, some issues constrain its applicability in practical cases, such as delays in map building and low map and UAS estimation accuracies. This paper proposes a 3D RO-SLAM scheme for UAS that specifically focuses on improving map building delays and accuracy levels without compromising efficiency in the consumption of resources. The scheme integrates sonar measurements together with range measurements between the robot and beacons deployed in the scenario. The proposed scheme presents two main advantages: (1) it integrates direct range measurements between the robot and the beacons and also range measurements between beacons — called inter-beacon measurements — which significantly reduce map building times and improve map and UAS localization accuracies; and (2) the SLAM scheme is endowed with a supervisory module that self-adapts the measurements that are integrated in SLAM reducing computational, bandwidth and energy consumption. Experimental validation in field experiments with an octorotor UAS showed that the proposed scheme improved map building times in 72%, map accuracy in 40% and UAS localization accuracy in 12%.
Comprehensive Evaluation of Medical Conditions Associated with Risk of Non-Hodgkin Lymphoma using Medicare Claims (“MedWAS”)
Authors: Engels Eric A. , Parsons Ruth , Besson Caroline , Morton Lindsay M. , Enewold Lindsey , Ricker Winnie , Yanik Elizabeth L. , Arem Hannah , Austin April A. , Pfeiffer Ruth M. 
Published: April 2016

AbstractBackground: Certain medical conditions affect risk of non-Hodgkin lymphoma (NHL), but the full range of associations is unknown. We implemented a novel method (“medical condition-wide association study,” MedWAS) to comprehensively evaluate medical risk factors for NHL documented in administrative health claims.Methods: Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we conducted a case–control study comparing NHL cases [N = 52,691, age 66+ years, with five subtypes: chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, marginal zone lymphoma (MZL), T-cell lymphoma (TCL)] to controls (N = 200,000). We systematically screened for associations with 5,926 medical conditions documented in Medicare claims more than 1 year before selection.Results: Fifty-five conditions were variously associated with NHL. Examples include well-established associations of human immunodeficiency virus, solid organ transplantation, and hepatitis C virus with increased DLBCL risk (ORs 3.83, 4.27, and 1.74, respectively), and autoimmune conditions with DLBCL and MZL (e.g., ORs of 2.10 and 4.74, respectively, for Sjögren syndrome). Risks for all NHL subtypes were increased after diagnoses of nonmelanoma skin cancer (ORs 1.19–1.55), actinic keratosis (1.12–1.25), or hemolytic anemia (1.64–4.07). Nine additional skin conditions increased only TCL risk (ORs 2.20–4.12). Diabetes mellitus was associated with increased DLBCL risk (OR 1.09). Associations varied significantly across NHL subtypes for 49 conditions (89%).Conclusion: Using an exploratory method, we found numerous medical conditions associated with NHL risk, and many associations varied across NHL subtypes.Impact: These results point to etiologic heterogeneity among NHL subtypes. MedWAS is a new method for assessing the etiology of cancer and other diseases. Cancer Epidemiol Biomarkers Prev; 25(7); 1105–13. ©2016 AACR.
In VivoFluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing
Authors: Lehmann Steffi , Perera Ramanil , Grimm Hans-Peter , Sam Johannes , Colombetti Sara , Fauti Tanja , Fahrni Linda , Schaller Teilo , Freimoser-Grundschober Anne , Zielonka Jörg , Stoma Szymon , Rudin Markus , Klein Christian , Umana Pablo , Gerdes Christian , Bacac Marina 
Published: April 2016

AbstractPurpose: CEA TCB (RG7802, RO6958688) is a novel T-cell bispecific antibody, engaging CD3ϵ upon binding to carcinoembryonic antigen (CEA) on tumor cells. Containing an engineered Fc region, conferring an extended blood half-life while preventing side effects due to activation of innate effector cells, CEA TCB potently induces tumor lysis in mouse tumors. Here we aimed to characterize the pharmacokinetic profile, the biodistribution, and the mode of action of CEA TCB by combining in vitro and in vivo fluorescence imaging readouts.Experimental Design: CEA-expressing tumor cells (LS174T) and human peripheral blood mononuclear cells (PBMC) were cocultured in vitro or cografted into immunocompromised mice. Fluorescence reflectance imaging and intravital 2-photon (2P) microscopy were employed to analyze in vivo tumor targeting while in vitro confocal and intravital time-lapse imaging were used to assess the mode of action of CEA TCB.Results: Fluorescence reflectance imaging revealed increased ratios of extravascular to vascular fluorescence signals in tumors after treatment with CEA TCB compared with control antibody, suggesting specific targeting, which was confirmed by intravital microscopy. Confocal and intravital 2P microscopy showed CEA TCB to accelerate T-cell–dependent tumor cell lysis by inducing a local increase of effector to tumor cell ratios and stable crosslinking of multiple T cells to individual tumor cells.Conclusions: Using optical imaging, we demonstrate specific tumor targeting and characterize the mode of CEA TCB–mediated target cell lysis in a mouse tumor model, which supports further clinical evaluation of CEA TCB. Clin Cancer Res; 22(17); 4417–27. ©2016 AACR.See related commentary by Teijeira et al., p. 4277
Impact of Guidelines on Clinical Practice
Authors: Chung Jong-Won , Kim Beom Joon , Han Moon-Ku , Ko Youngchai , Lee SooJoo , Kang Kyusik , Park Jong-Moo , Park Sang-Soon , Park Tai Hwan , Cho Yong-Jin , Hong Keun-Sik , Lee Kyung Bok , Lee Jun , Ryu Wi-Sun , Kim Dong-Eog , Nah Hyun-Wook , Kim Dae-Hyun , Cha Jae-Kwan , Kim Joon-Tae , Cho Ki-Hyun , Choi Jay Chol , Oh Mi-Sun , Yu Kyung-Ho , Lee Byung-Chul , Jang Myung Suk , Lee Ji Sung , Lee Juneyoung , Gorelick Philip B. , Yoon Byung-Woo , Bae Hee-Joon 
Published: April 2016

Background and Purpose—
Since its introduction, controversy has existed about the administration of intravenous heparin for the treatment of acute ischemic stroke. We studied trends in the intravenous heparin use during a 6-year time period and the potential influence of clinical guidelines in national language on intravenous heparin administration in Korea.

Methods—
On the basis of a prospective nationwide multicenter stroke registry, we collected data on patients with acute ischemic stroke who arrived within 7 days of symptom onset during the time period 2008 to 2013. We studied patient demographics, prestroke medical history, stroke characteristics, and stroke treatment. Data from a total of 23 425 patients from 12 university hospitals or regional stroke centers were analyzed.

Results—

The administration of intravenous heparin steadily decreased throughout the study period: 9.7% in 2008, 10.9% in 2009, 9.4% in 2010, 6.0% in 2011, 4.7% in 2012, and 4.3% in 2013 (
P
for trend <0.001). The reduced intravenous heparin use was associated with moderate stroke severity, atrial fibrillation, and stroke of cardioembolic, other-, and undetermined etiology. In a multivariable logistic model, increase of 1 calendar year (odds ratio, 0.89; 95% confidence interval, 0.84–0.95;
P
<0.001) and release of clinical practice guidelines in Korean (odd ratio, 0.74; 95% confidence interval, 0.59–0.91;
P
<0.01) were independent factors associated with reduction in the frequency of intravenous heparin use.

Conclusions—
Use of intravenous heparin for acute ischemic stroke treatment has decreased in Korea, and this change may be attributable to the spread and successful implementation of regional clinical practice guidelines.
A Survey of Word Reordering in Statistical Machine Translation: Computational Models and Language Phenomena
Authors: Bisazza Arianna , Federico Marcello 
Published: April 2016

Word reordering is one of the most difficult aspects of statistical machine translation (SMT), and an important factor of its quality and efficiency. Despite the vast amount of research published to date, the interest of the community in this problem has not decreased, and no single method appears to be strongly dominant across language pairs. Instead, the choice of the optimal approach for a new translation task still seems to be mostly driven by empirical trials.To orient the reader in this vast and complex research area, we present a comprehensive survey of word reordering viewed as a statistical modeling challenge and as a natural language phenomenon. The survey describes in detail how word reordering is modeled within different string-based and tree-based SMT frameworks and as a stand-alone task, including systematic overviews of the literature in advanced reordering modeling.We then question why some approaches are more successful than others in different language pairs. We argue that besides measuring the amount of reordering, it is important to understand which kinds of reordering occur in a given language pair. To this end, we conduct a qualitative analysis of word reordering phenomena in a diverse sample of language pairs, based on a large collection of linguistic knowledge. Empirical results in the SMT literature are shown to support the hypothesis that a few linguistic facts can be very useful to anticipate the reordering characteristics of a language pair and to select the SMT framework that best suits them.