bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phylogenetic analysis and predicted functional effect of protein mutations of E6 and E7 HPV16 strains isolated in Indonesia
Authors: Wulandari Dwi , Rachmadi Lisnawati , Sudiro Tjahjani M. 
Published: January 2016

Background: E6 and E7 are oncoproteins of HPV16. Natural amino acid variation in HPV16 E6 can alter its carcinogenic potential. The aim of this study was to analyze phylogenetically E6 and E7 genes and proteins of HPV16 from Indonesia and predict the effects of single amino acid substitution on protein function. This analysis could be used to reduce time, effort, and research cost as initial screening in selection of protein or isolates to be tested in vitro or in vivo.Methods: In this study, E6 and E7 gene sequences were obtained from 12 samples of Indonesian isolates, which were compared with HPV16R (prototype) and 6 standard isolates in the category of European (E), Asian (As), Asian-American (AA), African-1 (Af-1), African-2 (Af-2), and North American (NA) branch from Genbank. Bioedit v.7.0.0 was used to analyze the composition and substitution of single amino acids. Phylogenetic analysis of E6 and E7 genes and proteins was performed using Clustal X (1.81) and NJPLOT softwares. Effects of single amino acid substitutions on protein function of E6 and E7 were analysed by SNAP.Results: Java variants and isolate ui66* belonged to European branch, while the others belonged to Asian and African branches. Twelve changes of amino acids were found in E6 and one in E7 proteins. SNAP analysis showed two non neutral mutations, i.e. R10I and C63G in E6 proteins. R10I mutations were found in Af-2 genotype (AF472509) and Indonesian isolates (Af2*), while C63G mutation was found only in Af2*.Conclusion: E6 proteins of HPV16 variants were more variable than E7. SNAP analysis showed that only E6 protein of African-2 branch had functional differences compared to HPV16R.
Resilience Processes Supporting Adolescents With Intellectual Disability: A Multiple Case Study
Authors: Hall Anna-Marié , Theron Linda C. 
Published: January 2016

Abstract
Resilience, or the process of adjusting well to risk, relies on constructive collaboration between youths and their social ecologies. Although the literature details the risks of an intellectual disability (ID), there is little explanation of why some young people cope well despite these risks. Accordingly, we report a multiple case study that affords insight into the resilience of 24 adolescents with ID. Using a draw-and-talk methodology, these young people explained their resilience as enabled primarily by supportive social ecologies (which facilitated behavioral and emotional regulation, encouraged mastery, treated them as agentic beings, and offered safe spaces). Adolescents' positive orientation to their life-worlds co-facilitated their resilience. These insights advance effective ways to champion the resilience of young people with ID.
Ground Zero – the socio-political minefield of symbolic architecture
Authors: Libeskind Daniel , Cairns Graham 
Published: January 2016

Daniel Libeskind is today one of the architecture profession’s media elite. He took up his position in the list of ‘super star architects’ twenty ago and has remained in the spotlight of the press ever since. He has projects across the globe and has been awarded prizes by Time Magazine, The Goethe Institute, the American Institute of Architects and the RIBA. He was also appointed the first Cultural Ambassador for Architecture by the State Department of the United States in 2004. He has been both critically lauded and sardonically ridiculed. Tom Dyckhoff of the London Times refers to him as a ‘global brand’.
His most high profile project to date has been The Jewish Museum of Berlin which, after various years of partial completion, was finally opened in full on September 11 2001. The opening day of Libeskind’s commemoration of the twentieth century’s act of horror par excellence then, was also the day of the twenty-first century’s most iconic terrorist act. The macabre irony was not lost on Libeskind himself but the competition that led to him being appointed master planner and architect of the Ground Zero project, turned out to be a dirty, personalised and publically aired media circus. It was a story of political infighting, tawdry economic deals and architectural brinkmanship. It culminated ten years ago this month with Libeskind’s ‘victory.’ In this interview Daniel Libeskind looks back over a decade of working on this project and muses on one of the most high profile, emotive and polemic architectural projects of recent times.
Analysis of the association of polymorphisms CASR and VDR with the development of nephrolithiasis in patients with primary hyperparathyroidism
Authors: Peretokina Elena Viktorovna , Pigarova Ekaterina Aleksandrovna , Mokrysheva Natal'ya Georgievna , Rozhinskaya Lyudmila Yakovlevna , Baydakova Galina Viktorovna , Zakharova Ekaterina Yur'evna 
Published: January 2016

Pathogenesis of nephrolithiasis (NL) at PHPT is not fully understood. Meanwhile, the detection of NL patients with PHPT is an absolute indication for parathyroidectomy. Conducted various studies aimed at finding a predictor of NL patients with PHPT. Actively study the role of genetic markers, particularly genes that regulate calcium-phosphorus metabolism.Objective — to assess the relationship of polymorphisms CASR and VDR with the development of the NL at PHPТ.Material and methods. A study to include 203 patients with confirmed PHPT, out of which 114 patients had the NL and 87 patients without NL. All patients were studied indicators calcium-phosphorus metabolism, the study of the level of PTH, vitamin D, the filtration function of the kidneys. All patients were studied indicators calcium-phosphorus metabolism, the level of PTH, vitamin D, the filtration function of the kidneys. The study of gene polymorphisms VDR (FokI, TaqI, BsmI, ApaI, Cdx2) was performed in 169 patients (113 with NL, 56 without NL) by polymerase chain reaction followed by restriction analysis; Study 3 polymorphisms CASR (A986S, R990G, Q1011E) was performed in 187 patients (110 with NL, 77 without NL), by direct sequencing.Results. No significant differences in the frequency of genotypes and alleles studied genes between the two groups has been received. According to logistic regression analysis, the only predictor of NL is the level of ionized calcium.Conclusions. The studied genes can not be used as predictors of the NL. May need to investigate other genes.
Los Rankings Académicos
Authors: Post David , Stambach Amy , Ginsburg Mark , Hannum Emily , Benavot Aaron , Bjork Chris 
Published: January 2016

El uso de factores de impacto y rankings para evaluar publicaciones, instituciones e investigadores se relaciona con cuatro movimientos: la racionalización del conocimiento experto, asumido como una característica inherente a la autoridad burocrática; la política en la regulación y control de la educación superior, que se manifiesta en el nuevo “gerencialismo” y sus intentos de evaluar la investigación; las políticas de precios y finanzas de las editoriales académicas comerciales; y la actuación cada vez más dramática que se espera de los editores y sus revistas, aún cuando éstos se vean a sí mismos más como anfitriones de la convivencia y del pensamiento, que como empleados de línea en una fábrica de currículos.
La construcción de una ciudadanía intercultural inclusiva: instrumentos para su exploración
Authors: Maria Angeles Marin Gracia 
Published: January 2016

La multiculturalidad que caracteriza cada vez más nuestras sociedades exige más que nunca el desarrollo de un concepto de ciudadanía que favorezca la plena integración de las diferentes culturas que inevitablemente coexisten y una educación en la que se valore el enriquecimiento que supone la multiculturalidad para el conjunto de ciudadanos y ciudadanas como pilar fundamental para avanzar en la equidad, potenciar la conciencia democrática y facilitar la convivencia. En este artículo presentamos los elementos que sustentan un modelo educativo para la construcción de una ciudadanía intercultural inclusiva y una breve descripción del mismo. Se hace una descripción de los principales instrumentos para la exploración de los diferentes componentes del modelo, elaborados en diversas investigaciones del grupo GREDI (Grupo de investigación en educación intercultural).
Assessing Pre-service Teachers Prior to Certification: Perspectives on the Performance Assessment for California Teachers (PACT)
Authors: Okhremtchouk Irina , Newell Patrick , Rosa Rebecca 
Published: January 2016

This study focuses on pre-service teachers’ perspectives regarding how the process of completing the Performance Assessment for California Teachers (PACT) affected them academically, professionally, and personally. Two cohorts participated in this year-two study. Pre-service teachers’ perspectives were acquired using a survey instrument comprised of open-ended questions. In addition, pre-service teachers’ self-confidence levels pertaining to assessment task components of PACT (i.e., planning, instruction, assessment, reflection, and academic language) were measured prior to the execution of PACT portfolio assessment and these levels were compared to the actual scores on PACT. This study concludes with implications for teacher educators and teacher education programs implementing pre-service teacher assessments; these implications include policy level suggestions as well as a discussion of intended and unintended consequences of the PACT assessment on the pre-service teachers.
Evaluating the impact of NCLB school interventions in New York State: Does one size fit all?
Authors: Lee Jaekyung , Shin Hyejin , Amo Laura C. 
Published: January 2016

This study examines the efficacy and moderators of New York State interventions for schools in need of improvement under NCLB, including: (1) school transfer, (2) supplementary education service (3) corrective action, (4) planning for restructuring, and (5) restructuring. Despite the fact that schools in increasingly aggressive treatment groups had higher performance gains relative to schools in good standing, propensity score matching analysis results reveal negative or null effects of the interventions. There are indications of treatment effect heterogeneity and the effects varied by the year of implementation and the propensity of treatment assignment (schooling conditions prior to interventions). The findings of our study have implications for both theory of action and program implementation.
Examination of psychometric properties of the Turkish form of adult playfulness trait scale-APTS<p>Yetişkin eğlence eğilimi özeliği ölçeği Türkçe formunun psikometrik özelliklerinin incelenmesi
Authors: Keleş Sadiye 
Published: January 2016

<p>Adult playfulness helps children to reduce their negative feelings and go through more smooth transitions for new experiences, and this propounds the importance of examining the playfulness of teachers. The aim of this study is to examine the psychometric properties of Adult Playfulness Trait Scale (APTS)-Turkish Form in terms of teacher candidates. The study was conducted with 440 university students. Explanatory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were used to test the validity of the scale; and alpha value was calculated to test the reliability of the scale. Factor loadings and fit indices indicated that the construct validity of scale was high. Consequently, construct validity and reliability of scale were found to be high level. </p><p> </p><p><strong>Özet</strong></p><p>Bu çalışmanın amacı Yetişkin Eğlence Eğilimi Özeliği Ölçeği’nin (YEEÖÖ) Türkçe formunun psikometrik özelliklerinin öğretmen adayları açısından incelenmesidir. Araştırma 440 üniversite öğrencisi üzerinde gerçekleştirilmiştir. Ölçeğin geçerliği için Açımlayıcı Faktör Analizi (AFA) ve Doğrulayıcı Faktör Analizi (DFA); güvenirliği için ise alfa değeri hesaplanmıştır. Faktör yükleri ve uyum indekslerinin, ölçeğin yapı geçerliğinin yüksek düzeyde olduğuna işaret ettiği söylenebilmektedir. Sonuç olarak ölçeğin yapı geçerliği ve güvenirliğinin yüksek düzeyde olduğu belirlenmiştir.</p>
Statistical Testing of Segment Homogeneity in Classification of Piecewise–Regular Objects
Authors: Savchenko Andrey V. , Belova Natalya S. 
Published: January 2016

Abstract
The paper is focused on the problem of multi-class classification of composite (piecewise-regular) objects (e.g., speech signals, complex images, etc.). We propose a mathematical model of composite object representation as a sequence of independent segments. Each segment is represented as a random sample of independent identically distributed feature vectors. Based on this model and a statistical approach, we reduce the task to a problem of composite hypothesis testing of segment homogeneity. Several nearest-neighbor criteria are implemented, and for some of them the well-known special cases (e.g., the Kullback–Leibler minimum information discrimination principle, the probabilistic neural network) are highlighted. It is experimentally shown that the proposed approach improves the accuracy when compared with contemporary classifiers.
High Dynamic Range Imaging by Perceptual Logarithmic Exposure Merging
Authors: Florea Corneliu , Vertan Constantin , Florea Laura 
Published: January 2016

Abstract
In this paper we emphasize a similarity between the logarithmic type image processing (LTIP) model and the Naka–Rushton model of the human visual system (HVS). LTIP is a derivation of logarithmic image processing (LIP), which further replaces the logarithmic function with a ratio of polynomial functions. Based on this similarity, we show that it is possible to present a unifying framework for the high dynamic range (HDR) imaging problem, namely, that performing exposure merging under the LTIP model is equivalent to standard irradiance map fusion. The resulting HDR algorithm is shown to provide high quality in both subjective and objective evaluations.
Symbolic Computing in Probabilistic and Stochastic Analysis
Authors: Kamiński Marcin 
Published: January 2016

Abstract
The main aim is to present recent developments in applications of symbolic computing in probabilistic and stochastic analysis, and this is done using the example of the well-known MAPLE system. The key theoretical methods discussed are (i) analytical derivations, (ii) the classical Monte-Carlo simulation approach, (iii) the stochastic perturbation technique, as well as (iv) some semi-analytical approaches. It is demonstrated in particular how to engage the basic symbolic tools implemented in any system to derive the basic equations for the stochastic perturbation technique and how to make an efficient implementation of the semi-analytical methods using an automatic differentiation and integration provided by the computer algebra program itself. The second important illustration is probabilistic extension of the finite element and finite difference methods coded in MAPLE, showing how to solve boundary value problems with random parameters in the environment of symbolic computing. The response function method belongs to the third group, where interference of classical deterministic software with the non-linear fitting numerical techniques available in various symbolic environments is displayed. We recover in this context the probabilistic structural response in engineering systems and show how to solve partial differential equations including Gaussian randomness in their coefficients.
On two new records of rare Cystoseira taxa (Fucales, Phaeophyceae) from Greece (Eastern Mediterranean)
Authors: Tsiamis Konstantinos , Salomidi Maria , Kytinou Eleni , Issaris Yiannis , Gerakaris Vasilis 
Published: January 2016

Abstract
Two Mediterranean Cystoseira taxa, namely Cystoseira foeniculacea f. schiffneri and Cystoseira funkii, are added to the macroalgal flora of Greek seas, both of them being described for the first time in the Eastern Mediterranean Sea. Descriptions, photographs, habitat type and distribution details, as well as brief notes, are provided for each taxon. Both taxa are rare, protected by the Barcelona Convention, and were found within three Natura 2000 marine Sites of Community Importance, highlighting the importance of establishing and enforcing site-specific management measures to ensure conservation of these rare, Mediterranean endemic, and little known taxa.
Performance goals for immunoglobulins and serum free light chain measurements in plasma cell dyscrasias can be based on biological variation
Authors: Hansen Charlotte Toftmann 
Published: January 2016

AbstractMeasurements of immunoglobulins and serum free light chains (sFLC) are frequently used in patients with monoclonal plasma cell dyscrasia (PCD). For optimum patient care, well-defined performance standards or goals for the measured concentrations of immunoglobulins and sFLC are required. Generally, data based on biological variation is a good and reliable method for setting desirable performance standards; this also applies for the measurements of paraprotein and sFLC. The benefits of this approach are several. Among others, it is independent of the clinician, and it provides us with information about reference change value and index of individuality. Several studies on biological variation of both immunoglobulins and sFLC have been published, and mostly the studies are well performed. The studies normally show small within-subject biological variation resulting in strict analytical goals, which in most cases are difficult to meet. Nevertheless, we still need further information on biological variation of immunoglobulins and sFLC in patients with PCD and in the elderly, which are the main target populations for the two measurands. Furthermore, to improve data on biological variation of immunoglobulins and sFLC, studies accounting for number of individuals, samples, and replicates, as well as time length of the studies are needed.
Characterization and adsorption performance of chitosan/diatomite membranes for Orange G removal
Authors: Wu Xiu-Juan , Wang Ji-De , Cao Li-Qin 
Published: January 2016

AbstractNovel chitosan/diatomite (CS/DM) membranes were prepared by phase inversion technique to remove anionic azo dyes from wastewater. The fabricated composite membranes exhibited the combined advantages of inorganic substances, diatomites, and polysaccharides. These composite membranes were characterized through Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction analysis. The mechanical properties of the membranes were also evaluated. Adsorption experiments were conducted under varied initial dye concentration, solution pH values, contact time, and adsorbent dosage. The results indicate that pH 3 is the optimal pH value for Orange G adsorption. The CS/DM membranes exhibit the highest adsorption capacity of 588 mg g-1 and removal rate of 94% under an initial dye concentration of 200 mg l-1, contact time of 6 h, and membrane dosage of 8 mg. Langmuir, Freundlich and Redlich-Peterson adsorption models were applied to describe the equilibrium isotherms at different dye concentrations. The equilibrium data was found to be fitted well to the Redlich-Peterson isotherm. Pseudo-first-order and pseudo-second-order kinetics models were used to describe the adsorption of membranes. The adsorption data were well explained by pseudo-second-order models, and also followed by the Elovich model. In addition, these membranes display high adsorption capacity and mechanical performance even after reused for seven times.
How Effective is Population-Based Cancer Screening? Regression Discontinuity Estimates from the US Guideline Screening Initiation Ages
Authors: Kadiyala Srikanth , Strumpf Erin 
Published: January 2016

Abstract
We estimate the marginal benefits of population-based cancer screening by comparing cancer test and detection rates on either side of US guideline-recommended initiation ages (age 40 for breast cancer and age 50 for colorectal cancer during the study period). Using a regression discontinuity design and self-reported test data from national health surveys, we find test rates for breast and colorectal cancer increase at the guideline age thresholds by 109% and 78%, respectively. Data from cancer registries in twelve US states indicate that cancer detection rates increase at the same thresholds by 50% and 49%, respectively. We estimate significant effects of screening on earlier breast cancer detection (1.2 cases/1000 screened) at age 40 and colorectal cancer detection (1.1 cases/1000 individuals screened) at age 50. Forty-eight and 73% of the increases in breast and colorectal case detection occur among middle-stage cancers (localized and regional) with most of the remainder among early-stage (in-situ). Our analysis suggests that the cost of detecting an asymptomatic case of breast cancer at age 40 via population-based screening is $107,000–134,000 and that the cost of detecting an asymptomatic case of colorectal cancer at age 50 is $473,000–485,000.
The origin of the causative prefix in Rgyalrong languages and its implication for proto-Sino-Tibetan reconstruction
Authors: Jacques Guillaume 
Published: January 2016

AbstractIn this paper, the first detailed description of the two causative derivations in Japhug Rgyalrong is presented, based on a corpus of spontaneous speech. Two new pathways of grammaticalization are proposed. First, it is shown that the causative derives from a special type of denominal derivation. Second, a previously undocumented development from the causative to the abilitative derivation is described. Lastly, the implications of these grammaticalization hypotheses for the reconstruction of Sino-Tibetan morphology as a whole are evaluated.
A diachronic view of Zamucoan verb inflection
Authors: Ciucci Luca , Bertinetto Pier Marco 
Published: January 2016

AbstractThis paper presents a comparative analysis of the verb system of the three known Zamucoan languages, namely Old Zamuco, described by the Jesuit father Ignace Chomé in the first half of the eighteenth century, plus Ayoreo and Chamacoco, still actively spoken in the Chaco area between Bolivia and Paraguay. The analysis has confirmed the internal consistency of this language family, allowing us to build a plausible reconstruction of the Proto-Zamucoan verb system. The analysis has unsurprisingly pointed out Old Zamuco as the most conservative language among the three; Chamacoco, by contrast, appears to be the most innovative. This notwithstanding, Chamacoco also has conservative features that turn out to be particularly relevant for the purpose of linguistic reconstruction.
Reconstruction and idiomaticity: The origin of Russian verbless clauses reconsidered
Authors: Kopotev Mikhail 
Published: January 2016

AbstractThere are three types of Russian verbless clauses, which emerged through the ellipsis of the copula and other (full) verbs. This paper provides arguments against the hypothesis that they owe their existence to contact with Uralic languages. It argues that Finnic verbless clauses developed in parallel or even later than their Russian counterparts, and that the verbless clauses in Samoyedic languages, which preserve ancient Proto-Uralic features and use predicate nominal suffixes, differ structurally too much from those in Russian to represent likely models. It is argued that verbless clauses can naturally emerge when the meaning expressed by a frequent and semantically bleached verb is also included in the meaning of the phrase dependent on it. Other factors (contact-induced change, pragmatic and contextual factors) can support the emergence of – usually highly idiomatic – verbless clause constructions.
A Special Issue: Geomathematics in practice: Case studies from earth- and environmental sciences – Proceedings of the Croatian-Hungarian Geomathematical Congress, Hungary 2015
Authors: Hatvani István Gábor , Horváth Janina 
Published: January 2016

AbstractThe present paper aims to introduce the current problems of geomathematics along with giving on overview on the papers published in the special issue covering the Croatian-Hungarian Geomathematical Congress of 2015 in Hungary.