bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Profiles of Cohesion and Parenting Practices and Latino Youth Adjustment
Authors: Bámaca‐Colbert Mayra Y. , Gonzales‐Backen Melinda , Henry Carolyn S. , Kim Peter S.Y. , Roblyer Martha Zapata , Plunkett Scott W. , Sands Tovah 
Published: August 2017

Using a sample of 279 (52% female) Latino youth in 9th grade (M = 14.57, SD = .56), we examined profiles of family cohesion and parenting practices and their relation to youth adjustment. The results of latent profile analyses revealed four family profiles: Engaged, Supportive, Intrusive, and Disengaged. Latino youth in the Supportive family profile showed most positive adjustment (highest self‐esteem and lowest depressive symptoms), followed by youth in the Engaged family profile. Youth in the Intrusive and Disengaged profiles showed the lowest levels of positive adjustment. The findings contribute to the current literature on family dynamics, family profiles, and youth psychological adjustment within specific ethnic groups.
Effect of environment's aggressiveness on the corrosion damage evolution and mechanical behavior of AA 2024‐T3
Authors: Vasco M. C. , Chamos A. N. , Pantelakis Sp. G. 
Published: August 2017

The aim of this work is to contribute on establishing correlations between corrosion damage from accelerated laboratory corrosion tests of varying aggressiveness; by accounting for both, the metallographic features of corrosion damage and the mechanical properties of the corroded material. The work is based on the investigation of corrosion damage caused by the exposure of 2024‐T3 aluminum alloy to 3.5% NaCl solution, which is presently considered to properly represent in‐service exposure. Corrosion damage evolution was quantified for periods ranging between 500 and 3000 hours by evaluating pitting density, depth, and diameter. It was compared to available results of corrosion damage of the same alloy subjected to exfoliation corrosion test. Furthermore, the tensile properties of precorroded material in each solution were evaluated. The results allow the formulation of correlation functions between corrosion damage geometrical metallographic features from low‐ to high‐aggressiveness environment exposures. On the other hand, the degradation of tensile properties, and particularly of tensile ductility, is more pronounced in specimens exposed to higher corrosion rate environments, even when damage in both environments leads to equivalent metallographic features. This suggests significant differences in the underlying physical mechanisms of the damage accumulation process when the same material is exposed to different corrosive solutions. This work suggests the need to expand current corrosion damage interpretation, to account not only for geometrical metallographic features but also for mechanical properties of the affected material.
Constitutive relationship of polyolefin fibre–reinforced concrete: Experimental and numerical approaches to tensile and flexural behaviour
Authors: Enfedaque A. , Alberti M.G. , Gálvez J.C. , Beltrán M. 
Published: August 2017

AbstractFlexural tensile tests are usually used to evaluate the suitability of fibre‐reinforced concrete (FRC) in structural applications. The constitutive relationships of FRC are derived from such tests by using several inverse analyses. Given that the structural design of FRC is based on the residual load‐bearing capacities obtained under flexural tests, the approach to analyse fracture behaviour by means of uniaxial tensile tests would mean use of more direct and reliable constitutive curves compared with those obtained by indirect means. The significance of this paper lies in the characterisation of polyolefin fibre–reinforced concrete (PFRC) not only by using fracture flexural results tests but also by comparing such results with the direct tensile behaviour of the material obtained from uniaxial tests. This comparison would both extend the knowledge of the PFRC mechanical properties and broaden the reliability of structural design by comparing the behaviour of PFRC under flexural and tensile stresses. Moreover, the suitability of an iterative method proposed by the authors for obtaining the constitutive relations of PFRC from flexural tests has been checked by performing a series of numerical simulations of the tensile tests performed. The differences in the properties obtained in the flexural tests and the tensile tests have been assessed. The experimental results gathered from the tensile tests have been accurately reproduced by using a cohesive crack approach with trilinear softening functions by the iterative inverse analysis proposed.
Use of the anion gap and intermittent hemodialysis following continuous hemodiafiltration in extremely high dose acute‐on‐chronic lithium poisoning: A case report
Authors: Komaru Yohei , Inokuchi Ryota , Ueda Yoshihiro , Nangaku Masaomi , Doi Kent 
Published: August 2017

AbstractA 35‐year‐old woman intentionally took 40,000 mg of lithium carbonate, and she was transferred to our hospital with nausea, vomiting, and diarrhea. She was diagnosed as having bipolar disorder 10 years ago and was receiving oral lithium therapy. Blood test results on arrival were remarkable for a negative anion gap of −2.1 and later, the serum lithium level turned out to be as high as 15.4 mEq/L. Intubation was required because of disrupted consciousness, and continuous hemodiafiltration (CHDF) was immediately started in the intensive care unit to obtain constant removal of lithium. After adding intermittent hemodialysis (IHD) twice during the daytime to accelerate the lithium clearance, CHDF became unnecessary on day 4, and she was extubated on day 6 with complete recovery of consciousness. Close monitoring of the patient data showed recovery of the decreased anion gap as indicator of the serum lithium level reduction. On day 36, she was discharged without any complication and sequela. The current case highlighted the effective use of CHDF between IHD sessions to prevent the rebound elevation of lithium and the role of the anion gap as a surrogate marker of serum lithium concentration during the treatment.
Acute kidney injury in a postpartum woman with paroxysmal nocturnal hemoglobinuria: A case report and literature review
Authors: Nishimoto Masatoshi , Matsui Masaru , Tsushima Hideo , Tanabe Kaori , Tagawa Miho , Samejima Ken‐ich , Akai Yasuhiro , Saito Yoshihiko 
Published: August 2017

AbstractParoxysmal nocturnal hemoglobinuria is a rare clonal hematopoietic stem cell disorder characterized by intravascular hemolysis, hemoglobinuria, and inflammatory thrombotic state. Intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) can lead to acute and chronic renal injury through hemoglobin‐mediated toxicity. A 32‐year‐old pregnant woman with myelodysplastic syndrome was admitted to our hospital with severe preeclampsia. Shortly after an urgent caesarean section, she became obtunded and showed signs of acute kidney injury (AKI) with anuria, severe intravascular hemolysis, and hypermagnesemia. She was diagnosed with PNH with a positive Ham test and flow cytometry analysis. Renal magnetic resonance imaging revealed decreased signal intensity in the renal cortex due to hemosiderin deposition. Hemodialysis, plasma exchange, and administration of corticosteroids ameliorated her clinical condition and renal function. This case illustrates that careful management is required to prevent postpartum AKI in pregnant women with PNH.
Clinical significance of half‐lives of tumor markers α‐fetoprotein and des‐γ‐carboxy prothrombin after hepatectomy for hepatocellular carcinoma
Authors: Tsukamoto Masayo , Nitta Hidetoshi , Imai Katsunori , Higashi Takaaki , Nakagawa Shigeki , Okabe Hirohisa , Arima Kota , Kaida Takayoshi , Taki Katsunobu , Hashimoto Daisuke , Chikamoto Akira , Ishiko Takatoshi , Beppu Toru , Baba Hideo 
Published: August 2017

AimThe prognostic significance of the half‐lives (HLs) of α‐fetoprotein (AFP) and des‐γ‐carboxy prothrombin (DCP) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC) is unclear. We evaluated the HLs of AFP and DCP in a cohort of such patients.MethodsThis study included data on 202 patients with HCC who underwent curative hepatectomy and had preoperative AFP concentrations ≥100 ng/mL or DCP ≥200 mAU/mL. We calculated the HLs of AFP and DCP from their values just before and 1 month after hepatectomy. We identified three groups: a normalization group, tumor marker concentrations within normal range 1 month post‐hepatectomy; a long group, HL of AFP ≥7 days or DCP ≥4 days; and a short group, remaining patients. We evaluated associations between HL and prognosis.ResultsThree‐year recurrence‐free survival (RFS) in the normalization (n = 70), short (n = 71), and long groups (n = 61) was 41.3%, 46.0%, and 16.8%, respectively (P = 0.002). Five‐year overall survival (OS) of normalization, short, and long groups was 72.6, 70.6 and 43.8%, respectively (P = 0.002). Multivariate analysis revealed that long HL is an independent risk factor for poor RFS (hazard ratio [HR] 2.21, P = 0.0006) and poor OS (HR 2.70, P = 0.004). The extrahepatic recurrence rate was 21.3% (13/61) in the long group, which is higher than in the normalization group (8.6%, 6/70) (P = 0.04) and short group (9.9%, 7/71) (P = 0.07).ConclusionPost‐hepatectomy HLs of AFP and DCP are predictors of long‐term outcome in patients with HCC.
Clinicopathological analysis of 46 cases with CD4+ and/or CD56+ immature haematolymphoid malignancy: reappraisal of blastic plasmacytoid dendritic cell and related neoplasms
Authors: Suzuki Yuka , Kato Seiichi , Kohno Kei , Satou Akira , Eladl Ahmed E , Asano Naoko , Kono Michihiro , Kato Yuichi , Taniwaki Masafumi , Akiyama Masashi , Nakamura Shigeo 
Published: August 2017

AimsIn this study, we aimed to investigate the clinicopathological features of CD4+ and/or CD56+ immature haematolymphoid malignancy (iHLM), including blastic plasmacytoid dendritic cell neoplasm (BPDCN).Methods and resultsWe analysed the clinicopathological features of 46 patients diagnosed consecutively with CD4+/CD56+ iHLM. These cases were categorised into three groups based on their immunohistochemical expression of three plasmacytoid dendritic cell (pDC) markers [CD123, CD303 and T cell leukaemia/lymphoma (TCL1)]: cutaneous BPDCN (n = 35), non‐cutaneous BPDCN (n = 6) and non‐BPDCN‐type CD56+ neoplasms (n = 5). Compared to non‐cutaneous BPDCN, cutaneous BPDCN was associated with an older median age at onset (72 years versus 45 years, P < 0.05), and higher positivity for CD4 (P < 0.05), CD123 (P < 0.05) and 2–3 pDC markers (89% versus 50%, P = 0.05). Cutaneous BPDCN was divided into terminal deoxynucleotidyl transferase (TdT)+ and TdT− subgroups, which did not differ in prognosis, although TdT+ cases showed a lower median onset age (66 years versus 79 years, P < 0.05) and higher frequency of extracutaneous lesions (P < 0.05). Compared to the BPDCN groups, non‐BPDCN‐type CD56+ neoplasm cases showed higher cytoplasmic CD3 positivity (P < 0.05) and less frequent BCL‐2 expression (P < 0.05), and lacked cutaneous lesions. However, the survival curves overlapped. Notably, one case involved an unusual composite neoplasm, comprising CD56+ lymphoblastic lymphoma and mature CD56+ cytotoxic T cell lymphoma.ConclusionsOur present data support the recognition of cutaneous BPDCN as a homogenous entity, in contrast to the non‐cutaneous form. Additional research is warranted to characterise non‐BPDCN‐type CD56+ neoplasms.
Outcomes, costs and stakeholders' perspectives associated with the incorporation of community pharmacy services into the National Health Insurance System in Thailand: a systematic review
Authors: Asayut Narong , Sookaneknun Phayom , Chaiyasong Surasak , Saramunee Kritsanee 
Published: August 2017

AbstractObjectivesIdentify costs, outcomes and stakeholders' perspectives associated with incorporation of community pharmacy services into the Thai National Health Insurance System and their values to all stakeholders.MethodsUsing a combination of search terms, a comprehensive literature search was performed using the Thai Journal Citation Index Centre, Health System Research Institute database, PubMed and references from recent reviews. Identified studies were published between January 2000 and December 2014. The review included publications in English and Thai on primary research undertaken in community pharmacies associated with the National Health Insurance System. Two independent authors performed study selection, data extraction and quality assessment.Key findingsThe literature search yielded 251 titles, with 18 satisfying the inclusion criteria. Clinical outcomes of community pharmacy services included control and reduction in blood pressure and blood sugar, improved adherence to medications, an increase in acceptance of interventions, and an increase in healthy behaviours. Thirty-three percentage of those at risk of diabetes and hypertension achieved normal blood sugar and blood pressure levels after being followed for 2–6 months by a community pharmacist. The cost of collaborative screening by community pharmacies and primary care units was US$ 4.5. Diabetes management costs were US$ 5.1–30.7. Community pharmacists reported high satisfaction rates. Stakeholders' perspectives revealed support for the community pharmacists' roles and the inclusion of community pharmacies as partners with the National Health Insurance System.ConclusionsCommunity pharmacy services improved outcomes for diabetic and hypertensive patients. This review supports the feasibility of incorporating community pharmacies into the Thai National Health System.
Heat shock protein 70 from a thermotolerant Diptera species provides higher thermoresistance to Drosophila larvae than correspondent endogenous gene
Authors: Shilova V. Y. , Zatsepina O. G. , Garbuz D. G. , Funikov S. Y. , Zelentsova E. S. , Schostak N. G. , Kulikov A. M. , Evgen'ev M. B. 
Published: August 2017

AbstractHeat shock proteins (Hsp70s) from two Diptera species that drastically differ in their heat shock response and longevity were investigated. Drosophila melanogaster is characterized by the absence of Hsp70 and other hsps under normal conditions and the dramatic induction of hsp synthesis after temperature elevation. The other Diptera species examined belongs to the Stratiomyidae family (Stratiomys singularior) and exhibits high levels of inducible Hsp70 under normal conditions coupled with a thermotolerant phenotype and much longer lifespan. To evaluate the impact of hsp70 genes on thermotolerance and longevity, we made use of a D. melanogaster strain that lacks all hsp70 genes. We introduced single copies of either S. singularior or D. melanogaster hsp70 into this strain and monitored the obtained transgenic flies in terms of thermotolerance and longevity. We developed transgenic strains containing the S. singularior hsp70 gene under control of a D. melanogaster hsp70 promoter. Although these adult flies did synthesize the corresponding mRNA after heat shock, they were not superior to the flies containing a single copy of D. melanogaster hsp70 in thermotolerance and longevity. By contrast, Stratiomyidae Hsp70 provided significantly higher thermotolerance at the larval stage in comparison with endogenous Hsp70.
Synthesis and growth mechanism of approximate spherical β‐Si3N4particles via carbothermal reduction‐nitridation method
Authors: Sun Si‐Yuan , Wang Qi , Ge Yi‐Yao , Tian Zhao‐Bo , Zhang Jie , Chen Ke‐Xin , Xie Zhi‐Peng 
Published: August 2017

AbstractIn this work, an efficient carbothermal reduction‐nitridation (CRN) strategy was rationally designed to directly synthesize β‐Si3N4powders with eminent dispersity and granularity uniformity. With the aid of CaO additive, the obtained β‐Si3N4particles were endowed with approximate spherical morphology and smooth surface. The size of β‐Si3N4particles could be regulated in submicro and microscale by altering N2pressures. More significantly, the underlying growth mechanism of the β‐Si3N4under elevated N2pressure was comprehensively analyzed and tentatively put forward. Benefiting from the remarkable merits, the as‐synthesized β‐Si3N4powders showed great potential for alternative fillers in the application of high thermal conductivity plastic packages.
How teachers integrate a math computer game: Professional development use, teaching practices, and student achievement
Authors: Callaghan M. N. , Long J. J. , van Es E. A. , Reich S. M. , Rutherford T. 
Published: August 2017

AbstractAs more attention is placed on designing digital educational games to align with schools' academic aims (e.g., Common Core), questions arise regarding how professional development (PD) may support teachers' using games for instruction and how such integration might impact students' achievement. This study seeks to (a) understand how teachers use PD resources (e.g., technology personnel and game‐use workshops) for integration; (b) determine how teachers integrate games into their instruction; and (c) examine how those teaching practices are associated with student achievement. This mixed method study used survey and interview responses from elementary school teachers (n = 863) with access to PD resources for implementing a math game intervention and standardized math‐test scores from their second‐ through sixth‐grade students (n = 10,715). Findings showed few teachers sought PD assistance for integration, but many desired such support. Some reported using integrative practices (i.e., referencing game and using game‐generated progress reports) to identify struggling students, whereas several found integration challenging. Teachers' reordering of game objectives to align with lessons and viewing of game‐based PD videos were associated with increased student math achievement in our OLS‐analysis. However, this result was no longer statistically significant within a school fixed‐effects model, suggesting school differences may influence how strongly teachers' practices are associated with student achievement.
Insulin‐producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis‐related genes
Authors: Hosokawa Yoshiya , Toyoda Taro , Fukui Kenji , Baden Megu Yamaguchi , Funato Michinori , Kondo Yasushi , Sudo Tomomi , Iwahashi Hiromi , Kishida Marina , Okada Chihiro , Watanabe Akira , Asaka Isao , Osafune Kenji , Imagawa Akihisa , Shimomura Iichiro 
Published: August 2017

AbstractAims/IntroductionThe present study was carried out to generate induced pluripotent stem cells (iPSCs) from patients with fulminant type 1 diabetes, and evaluate the cytokine‐induced apoptotic reactions of β‐like insulin‐producing cells differentiated from the iPSCs.Materials and MethodsiPSCs were generated from fibroblasts of patients with fulminant type 1 diabetes by inducing six reprogramming factors. Insulin‐producing cells were differentiated from the iPSCs in vitro. The proportion of cleaved caspase‐3‐positive or terminal deoxynucleotidyl transferase 2′‐deoxyuridine, 5′‐triphosphate nick end labeling‐positive cells among insulin (INS)‐positive cells derived from fulminant type 1 diabetes iPSC and control human iPSC lines was evaluated under treatment with tumor necrosis factor‐α, interleukin‐1β and interferon‐γ. Ribonucleic acid sequencing was carried out to compare gene expressions in INS‐positive cells derived from fulminant type 1 diabetes iPSC and control human iPSC lines.ResultsTwo iPSC clones were established from each of three patients with fulminant type 1 diabetes. The differentiation of insulin‐producing cells from fulminant type 1 diabetes iPSC was confirmed by immunofluorescence analysis and KCl‐induced C‐peptide secretion. After treatment with pro‐inflammatory cytokines, these INS‐positive cells showed higher expression of cleaved caspase‐3 than those derived from control human iPSCs. Altered expression levels of several apoptosis‐related genes were observed in INS‐positive cells derived from the fulminant type 1 diabetes iPSCs by ribonucleic acid sequencing.ConclusionsWe generated iPSCs from patients with fulminant type 1 diabetes and differentiated them into insulin‐producing cells. This in vitro disease model can be used to elucidate the disease mechanisms of fulminant type 1 diabetes.
Factors associated with greater benefit of a national reimbursement policy for blood glucose test strips in adult patients with type 1 diabetes: A prospective cohort study
Authors: Jin Sang‐Man , Baek Jong Ha , Suh Sunghwan , Jung Chang Hee , Lee Woo Je , Park Cheol‐Young , Yang Hae Kyung , Cho Jae Hyoung , Lee Byung‐Wan , Kim Jae Hyeon 
Published: August 2017

AbstractAims/IntroductionWe aimed to identify factors independently associated with greater benefit of a national reimbursement policy for blood glucose test strips in adult patients with type 1 diabetes, in terms of glycemic control and the rate of severe hypoglycemia.Materials and MethodsThis was a prospective cohort study of 466 adult patients with type 1 diabetes from five tertiary referral hospitals who registered for a national reimbursement program for blood glucose strips and were then followed‐up for 12 months. Factors associated with a > 5% reduction in glycated hemoglobin (HbA1c) and decreased rate of severe hypoglycemia (SH) at 12 months from baseline were evaluated.ResultsAt the end of the 12 months of follow up, 158 of 466 patients (33.9%) achieved >5% reduction in HbA1c, and 47 of 111 patients (42.3%) had a decreased rate of SH relative to baseline. Higher HbA1c (P < 0.001), lower total daily insulin dose at baseline (P = 0.048) and an increase in self‐monitoring of blood glucose (SMBG) frequency during follow up (P = 0.001) were independently associated with >5% reduction in HbA1c. A higher SMBG frequency (P < 0.001), higher rate of SH at baseline (P = 0.029) and lack of hypoglycemic unawareness (P = 0.044) were independently associated with an increase in the frequency of SMBG during follow up. Higher SMBG frequency at baseline (P < 0.001) was independently associated with a decreased rate of SH.ConclusionsSeveral factors, including higher SMBG frequency at baseline, were independently associated with reduced HbA1c and a decreased rate of severe hypoglycemia, showing that patients with these characteristics derive the most benefit from reimbursement of blood glucose test strips.