bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canonical coordinates for Yang-Mills-Chern-Simons theory
Authors: Henningson Måns 
Published: October 2024

Abstract
We consider the classical field theory of 2+1-dimensional Yang-Mills-Chern-Simons theory on an arbitrary spatial manifold. We first define a gauge covariant transverse electric field strength, which together with the gauge covariant scalar magnetic field strength can be taken as coordinates on the classical phase space. We then determine the Poisson-Dirac bracket and find that these coordinates are canonically conjugate to each other. The Hamiltonian is non-polynomial when expressed in terms of these coordinates, but can be expanded in a power series in the coupling constant with polynomial coefficients.
Endoscopy for affine Hecke categories
Authors: Li Yau Wing 
Published: October 2024

AbstractWe show that the neutral block of the affine monodromic Hecke category for a reductive group is monoidally equivalent to the neutral block of the affine Hecke category for its endoscopic group. The semisimple complexes of both categories can be identified with the generalized Soergel bimodules via the Soergel functor. We extend this identification of semisimple complexes to the neutral blocks of the affine Hecke categories by the technical machinery developed by Bezrukavnikov and Yun.
Resolvent decomposition with applications to semigroups and cosine functions
Authors: Gregosiewicz Adam 
Published: October 2024

Abstract
For an operator whose domain is the kernel of a functional that is a finite sum of simpler functionals, we show that the resolvent of the operator can be decomposed as an affine combination of resolvents associated with these simpler functionals. Specifically, given an operator A and a finite number of functionals

$$\phi $$

ϕ

defined on the domain of A, we prove that the resolvent

$$(\lambda - A_{|\ker \sum \phi })^{-1}$$

(
λ
-

A

|
ker
∑
ϕ

)

-
1

is an affine combination of resolvents

$$(\lambda - A_{|\ker \phi })^{-1}$$

(
λ
-

A

|
ker
ϕ

)

-
1

, provided that the sum of the functionals is nontrivial on the kernel of

$$\lambda - A$$

λ
-
A

. We use this result to derive generation theorems for semigroups and cosine functions.As applications, we prove that there are cosine functions associated with skew and snapping out Brownian motions on star graphs, and that skew Brownian motion can be approximated by snapping out Brownian motion.
Curcumin as a complementary treatment in oncological therapy: a systematic review
Authors: Gutsche Lisa C. , Dörfler Jennifer , Hübner Jutta 
Published: October 2024

Abstract
Purpose
Curcumin, the active ingredient in turmeric, is employed by numerous cancer patients to support conventional cancer therapy. This systematic review aims to summarize the existing clinical evidence and to provide an overview of the potential benefits and risks associated with curcumin supplementation.

Methods
In January 2024, we conducted a systematic search of five electronic databases (Embase, Cochrane, PsycInfo, CINAHL, and Medline) using a complex search strategy. We included randomized controlled trials on the use, effectiveness, and potential harm of additional curcumin therapy in adult patients under cancer treatment. The risk of bias was assessed using Cochrane revised Risk of Bias Tool 2.0.

Results
This systematic review included 34 randomized controlled trials involving 2580 patients out of 11143 search results. Included patients were primarily diagnosed with head and neck cancer, followed by breast, prostate, and colorectal cancer. Therapy concepts encompassed topical or systemic curcumin administration. The studies reported heterogeneous results concerning oral and skin symptoms, pain, weight alteration and changes in body composition, survival, and disease progression. Significant findings were reported for oral mucositis and weight loss. Considering risk of bias, all studies had moderate to high risk of bias. Regarding side effects, one study reported significantly more vomiting in the curcumin group.

Conclusion
Although the results suggest promise in reducing mucositis and weight loss, a clear statement regarding the effectiveness of curcumin therapy on cancer patients cannot be made due to heterogeneous results and methodological limitations of the involved studies. Further investigations of higher quality are necessary to derive a definite recommendation for action.
Numerical evaluation of wear parameters using meta-models
Authors: El Masri Samir , Hartung Felix , Berger Thomas , Kaliske Michael 
Published: October 2024

Abstract
Wear parameters identified by linear friction tester (LFT) experiments overestimate the wear mass loss when applied on a laboratory abrasion & skid tester 100 (LAT100) simulation. On the other hand, the identification of wear parameters directly from the LAT100 experiment can be challenging since variables such as the contact area and the slip velocity are not measured experimentally and need to be assumed. To improve the identification process, numerical calibration is used as a more suitable approach. This approach relies on meta-models as a target function for minimization. The meta-models are generated using a sample of wear parameters applied to an LAT100 finite element modeling (FEM) to calculate the corresponding wear mass.. In this model, a transport velocity is defined for the rolling simulation, and an arbitrary lagrangian–eulerian (ALE) adaptive meshing approach is adopted for the wear modeling. For the wear model, a combination of archard’s wear model and schallamach’s abrasion law is used. This model contains a pair of wear parameters to be identified. The ALE adaptive meshing technique moves the nodes independently of the material. Since the mesh topology remains the same, failure of the simulation occurs if the wear volume loss exceeds that of the element. Meta-models are created to extend wear modeling beyond this failure. Once the meta-models are created, they are used as a target function for the minimization algorithm. The minimization algorithm aims to find the optimal wear parameters by minimizing the difference between experimentally observed and numerically produced wear mass loss. The minimization algorithm inputs a set of wear parameters into the meta-models which in turn yield a prediction of the wear mass loss. The process is carried out until an optimum parameter set is identified. Such an approach has a lower accuracy if the parameters are identified directly from the experiment using assumptions regarding the contact shear stress and the sliding velocity. Nonetheless, the main advantage of parameters identified using the meta-model approach is the usability of these parameters in an LAT100 model.
Model selection for mixture hidden Markov models: an application to clickstream data
Authors: Urso Furio , Abbruzzo Antonino , Chiodi Marcello , Cracolici Maria Francesca 
Published: October 2024

AbstractIn a clickstream analysis setting, Mixture Hidden Markov Models (MHMMs) can be used to examine categorical sequences assuming they evolve according to a mixture of latent Markov processes, each related to a different subpopulation. These models involve identifying both the number of subpopulations and hidden states. This study proposes a model selection criterion based on an integrated completed likelihood approach that accounts for the two latent classes in the model. We implemented a Monte Carlo simulation study to compare selection criteria performance. In scenarios characterised by categorical short length sequences, our proposed measure outperforms the most commonly used model selection criteria in identifying components and states. The paper presents a case study on clickstream data collected from the website of a company operating in the hospitality industry and modelled by an MHMM selected by the proposed score.
A comparison of single and double generator formalisms for thermodynamics-informed neural networks
Authors: Urdeitx Pau , Alfaro Icíar , González David , Chinesta Francisco , Cueto Elías 
Published: October 2024

AbstractThe development of inductive biases has been shown to be a very effective way to increase the accuracy and robustness of neural networks, particularly when they are used to predict physical phenomena. These biases significantly increase the certainty of predictions, decrease the error made and allow considerably smaller datasets to be used. There are a multitude of methods in the literature to develop these biases. One of the most effective ways, when dealing with physical phenomena, is to introduce physical principles of recognised validity into the network architecture. The problem becomes more complex without knowledge of the physical principles governing the phenomena under study. A very interesting possibility then is to turn to the principles of thermodynamics, which are universally valid, regardless of the level of abstraction of the description sought for the phenomenon under study. To ensure compliance with the principles of thermodynamics, there are formulations that have a long tradition in many branches of science. In the field of rheology, for example, two main types of formalisms are used to ensure compliance with these principles: one-generator and two-generator formalisms. In this paper we study the advantages and disadvantages of each, using classical problems with known solutions and synthetic data.
Intraoperative visualization of cerebral aneurysms using navigated 3D-ultrasound power-Doppler angiography
Authors: Šteňo Andrej , Buvala Ján , Malchárková Sofia , Mižičková Magdaléna , Bažík Rastislav , Mikula Peter , Bízik Ivan , Šteňo Juraj 
Published: October 2024

Abstract

Background
The questions of whether the spatial resolution of navigated 3D-ultrasound (3D-US) power-Doppler angiography imaging rendered by existing 3D-US systems is sufficient for the intraoperative visualization of cerebral aneurysms, and in what percentage of cases, are largely unanswered. A study on this topic is lacking in the literature.

Methods
From 2015 to 2022, we performed 86 surgeries on 83 aneurysm patients. Navigated 3D-US was used at the discretion of the operating neurosurgeons when available (i.e., not being used during parallel tumor surgeries). Twenty-five aneurysms (15 ruptured) were operated on using 3D-US; 22 aneurysms were located at the middle cerebral artery (MCA). Patient 3D-US power-Doppler angiography images and surgical reports were retrospectively reviewed to assess the intraoperative ultrasound visibility of aneurysms.

Results
In 20 patients (80%) the aneurysms were successfully visualized. In five patients (20%), the aneurysms visualization was insufficient or absent. Nineteen of 22 aneurysms (86.4%) were visualized in the MCA aneurysm subgroup. We observed no association between aneurysm visibility and aneurysm size or the presence of subarachnoid hemorrhage. In the subgroup of MCA aneurysms, no association between aneurysm visibility and the presence of subarachnoid hemorrhage was found; a trend toward poor sonographic visibility of smaller aneurysms was observed (p = 0.09).

Conclusions
Our initial data show that intraoperative 3D-US power-Doppler angiography, rendered by current navigated 3D-US systems, clearly depicts the majority of aneurysms in the MCA aneurysm subgroup. However, future prospective studies performed on a higher number of aneurysms localized at various anatomic sites are needed to confirm our initial findings and determine their potential clinical relevance.
Equivalent spring-like system for two nonlinear springs in series: application in metastructure units design
Authors: Cveticanin L. 
Published: October 2024

AbstractThe paper deals with the problem of design of unit in auxetic metastructure. The unit is modeled as a two-part spring-like system where each part is with individual stiffness. To overcome the problem of analyzing of each of parts separately, the equivalent spring is suggested to be introduced. In the paper, a method for obtaining the equivalent elastic force of the unit is developed. The method is the generalization of the procedure suggested for substitution of a hard and a soft spring in series with an equivalent one. The nonlinearity of original springs is of quadratic order. As a results, it is obtained that the equivalent elastic force for two equal springs remains of the same type as of the original springs (soft or hard). For two opposite type springs in series with equal coefficients, the equivalent force is soft. The method is applicable for any hard and soft nonlinear springs or spring-like systems. Thus the hexagonal auxetic unit which contains a soft and a hard part in series is analyzed. In the paper, a new analytic method for determination of the frequency of vibration for the unit under action of a constant compression force acting along the unit axis is introduced. The method is applied for units which contain two parts: hard–hard, soft–soft, hard–linear, soft–linear and opposite. The obtained approximate vibration results are compared with numerically obtained ones and show good agreement. The advantage of the method is its simplicity as it does not require the nonlinear equation of motion to be solved.
The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice
Authors: Gobert Alain P. , Latour Yvonne L. , McNamara Kara M. , Hawkins Caroline V. , Williams Kamery J. , Asim Mohammad , Barry Daniel P. , Allaman Margaret M. , Delgado Alberto G. , Milne Ginger L. , Zhao Shilin , Piazuelo M. Blanca , Washington M. Kay , Coburn Lori A. , Wilson Keith T. 
Published: October 2024

AbstractCystathionine γ-lyase (CTH) is a critical enzyme in the reverse transsulfuration pathway, the major route for the metabolism of sulfur-containing amino acids, notably converting cystathionine to cysteine. We reported that CTH supports gastritis induced by the pathogen Helicobacter pylori. Herein our aim was to investigate the role of CTH in colonic inflammation. First, we found that CTH is induced in the colon mucosa in mice with dextran sulfate sodium-induced colitis. Expression of CTH was completely absent in the colon of Cth–/– mice. We observed that clinical and histological parameters are ameliorated in Cth-deficient mice compared to wild-type animals. However, Cth deletion had no effect on tumorigenesis and the level of dysplasia in mice treated with azoxymethane-DSS, as a reliable model of colitis-associated carcinogenesis. Mechanistically, we determined that the deletion of the gene Slc7a11 encoding for solute carrier family 7 member 11, the transporter of the anionic form of cysteine, does not affect DSS colitis. Lastly, we found that the richness and diversity of the fecal microbiota were significantly increased in Cth–/– mice compared to both WT and Slc7a11–/– mice. In conclusion, our data suggest that the enzyme CTH represents a target for clinical intervention in patients with inflammatory bowel disease, potentially by beneficially reshaping the composition of the gut microbiota.
Structure-activity relationship of amino acid analogs to probe the binding pocket of sodium-coupled neutral amino acid transporter SNAT2
Authors: Jakobsen Sebastian , Pedersen Maria , Nielsen Carsten Uhd 
Published: October 2024

AbstractThe sodium-coupled neutral amino acid transporter SNAT2 (SLC38A2) has been shown to have important physiological functions and is implicated in various diseases like cancer. However, few compounds targeting this transporter have been identified and little is known about the structural requirements for SNAT2 binding. In this study, the aim was to establish the basic structure-activity relationship for SNAT2 using amino acid analogs. These analogs were first studied for their ability to inhibit SNAT2-mediated 3H-glycine uptake in hyperosmotically treated PC-3 cells. Then to identify substrates a FLIPR membrane potential assay and o-phthalaldehyde derivatization of intracellular amino with subsequent quantification using HPLC-Fl was used. The results showed that ester derivatives of the C-terminus maintained SNAT2 affinity, suggesting that the negative charge was less important. On the other hand, the positive charge at the N-terminus of the substrate and the ability to donate at least two hydrogen bonds to the binding site appeared important for SNAT2 recognition of the amine. Side chain charged amino acids generally had no affinity for SNAT2, but their non-charged derivatives were able to inhibit SNAT2-mediated 3H-glycine uptake, while also showing that amino acids of a notable length still had affinity for SNAT2. Several amino acid analogs appeared to be novel substrates of SNAT2, while γ-benzyl L-glutamate seemed to be inefficiently translocated by SNAT2. Elaborating on this structure could lead to the discovery of non-translocated inhibitors of SNAT2. Thus, the present study provides valuable insights into the basic structural binding requirements for SNAT2 and can aid the future discovery of compounds that target SNAT2.
Assessing the practice of total neoadjuvant therapy for rectal cancer: an online survey among radiation oncology departments in Germany and German-speaking regions of Austria and Switzerland
Authors: Knippen Stefan , Hildebrandt Guido , Putz Florian , Gossé Lasse Leon , Ritz Jörg-Peter , Duma Marciana-Nona 
Published: October 2024

AbstractTotal neoadjuvant therapy (TNT) of rectal cancer improves rates of pathological complete remission and progression-free survival. With improved clinical response rates, interest grew in a non-operative approach/watch and wait (WaW) for this disease. In 2020, the working groups of ACO/AIO/ARO published a consensus statement on the use of TNT, including a non-operative approach. However, the best combination scheme remains unclear. Despite the increasing use of TNT, there is a lack of comprehensive data on its current implementation and practices. To address this knowledge gap, a multicenter survey was conducted to capture the use of TNT protocols in German-speaking radiotherapy departments. At the beginning of 2023, a GDPR-compliant online survey was conducted in Germany, Austria, and German-speaking Switzerland. The questionnaire comprised 43 questions covering various aspects of TNT, including chemotherapy and WaW concepts. Most respondents (98.4%) confirmed awareness of the consensus on TNT for rectal cancer. Institutions treated an average of 30.22 rectal cancer patients annually. Most respondents (76.2%) reported treating over 80% of patients neoadjuvantly. Regarding TNT, 33.3% treated 21–50% with such a protocol. No significant association was found between the institution type and TNT application. In 62/63 cases, tumor board discussion was standard before offering TNT. VMAT was the predominant technique (82.5%). For rectal cancer dosing, the 50/50.4Gy scheme was most common, followed by 45Gy with a boost and the 5 × 5Gy scheme. Dosing schemes for TNT varied slightly, with more participants reporting the use of 5 × 5Gy compared to radiation therapy for rectal cancer in general. CBCT was the primary IGRT method (88.9%). Larger hospitals typically administered chemotherapy themselves, while private practices collaborated with medical oncologists (p < 0.0001). The most common concurrent chemotherapy drugs were 5-fluorouracil/capecitabine (64.4%) and oxaliplatin (37.3%). A WaW strategy was reported to be institutional implemented by 63.8%. The timing of offering WaW was split, with 50% offering it after radiochemotherapy and 47% during the informed consent talk. For planned WaW, 62% prefer normofractionated TNT. TNT appears to be widely implemented in the German-speaking radio-oncological community, regardless of the type of institution. Image-guided therapy, multidisciplinary team decisions, and internal guidelines play an important role. TNT seems to have already altered treatment protocols for rectal cancer toward an organ-preserving approach in selected cases. In these WaW cases, normofractionation appears to be preferred over hypofractionation.
Using the Health Belief Model to Understand Why Making Oral HIV Self-Testing Available to Truck Drivers in Kenya Had Little Impact on Six-Month Testing
Authors: Oo Thae Aient Aient , Romo Matthew L. , George Gavin , Mwai Eva , Nyaga Eston , Mantell Joanne E. , Odhiambo Jacob O. , Govender Kaymarlin , Kelvin Elizabeth A. 
Published: October 2024

AbstractResearch has found that offering HIV self-testing (HIVST) to truckers in Kenya increased testing rates at baseline but not over 6-month follow-up. We explored possible explanations based on the Health Belief Model by assessing HIV risk perception, self-efficacy, and fatalism as possible effect modifiers of the impact of offering HIVST (intervention n = 150) versus standard of care (SOC n = 155) on 6-month testing on the multiplicative and additive scales using log binomial and linear binomial regression and stratifying on significant modifiers. We found significant interaction between the intervention and fatalism on both the multiplicative (p = 0.020) and additive (p = 0.020) scales. In the stratified models, the HIVST intervention was associated with higher HIV testing among participants with low fatalism but lower testing among those with high fatalism (risk ratio [RR] = 1.30, p = 0.065 versus RR = 0.74, p = 0.072; risk difference [RD] per 100 = 14.00, p = 0.080 versus RD=-14.69, p = 0.086). Truckers in Kenya are described as being highly fatalistic, feeling lack of control over their lives and health. We found that fatalistic views negated the potential benefit of offering HIVST to truckers. For HIVST to have an impact among truckers, psychosocial interventions may be needed that address fatalistic views.
Tire wear monitoring using feature fusion and CatBoost classifier
Authors: Prasshanth C. V. , Sugumaran V. 
Published: October 2024

AbstractAddressing the critical issue of tire wear is essential for enhancing vehicle safety, performance, and maintenance. Worn-out tires often lead to accidents, underscoring the need for effective monitoring systems. This study is vital for several reasons: safety, as worn tires increase the risk of accidents due to reduced traction and longer braking distances; performance, as uneven tire wear affects vehicle handling and fuel efficiency; maintenance costs, as early detection can prevent more severe damage to suspension and alignment systems; and regulatory compliance, as ensuring tire integrity helps meet safety regulations imposed by transportation authorities. In response, this study systematically evaluates tire conditions at 25%, 50%, 75%, and 100% wear, with an intact tire as a reference, using vibration signals as the primary data source. The analysis employs statistical, histogram, and autoregressive–moving-average (ARMA) feature extraction techniques, followed by feature selection to identify key parameters influencing tire wear. CatBoost is used for feature classification, leveraging its adaptability and efficiency in distinguishing varying wear patterns. Additionally, the study incorporates feature fusion to combine different types of features for a more comprehensive analysis. The proposed methodology not only offers a robust framework for accurately classifying tire wear levels but also holds significant potential for real-time implementation, contributing to proactive maintenance practices, prolonged tire lifespan, and overall vehicular safety.