bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of the U‐shaped flap technique in preventing reflux after minimally invasive proximal gastrectomy for proximal gastric and esophagogastric junction cancer
Authors: Omori Takeshi , Hara Hisashi , Yanagimoto Yoshitomo , Shinno Naoki , Masuike Yasunori , Kanemura Takashi , Wada Hiroshi , Yasui Masayoshi , Ohue Masayuki , Miyata Hiroshi 
Published: October 2024

AbstractBackgroundPreventing gastroesophageal reflux after proximal gastrectomy for proximal gastric and esophagogastric junction cancer remains challenging due to the lack of standardized reconstructive techniques. The double flap technique (DFT) in valvuloplastic esophagogastrostomy prevents reflux esophagitis but is less effective in esophagogastric junction cancer because of negative pressure on the inferior mediastinum. We developed the U‐shaped flap technique (UFT) to enhance the anti‐reflux efficacy.MethodsThis study analyzed data from patients who underwent minimally invasive proximal gastrectomy for proximal gastric and esophagogastric junction cancer between August 2014 and May 2022, using a prospectively maintained database. We compared DFT and UFT for short‐ and long‐term outcomes, focusing on gastroesophageal reflux, using one‐to‐one propensity score matching to control for patient‐related variables.ResultsAmong 217 eligible patients, 205 (100 in DFT, 105 in UFT) completed a 1‐year follow‐up. After propensity score matching, we selected 42 pairs of patients who underwent DFT and UFT. UFT had significantly shorter operative time (p = 0.044), similar blood loss, and similar morbidity. The UFT group had significantly fewer reflux symptoms (0% vs. 14.3%, p = 0.0011) and endoscopic Los Angeles grade B or higher reflux esophagitis (0% vs. 14.3%, p = 0.0011) than the DFT group. In lower mediastinal reconstructions for esophagogastric junction cancer, UFT showed a reduced incidence of reflux esophagitis.ConclusionOur study indicates that the U‐shaped flap technique (UFT) offered significant advantages in reducing postoperative reflux symptoms and endoscopic esophagitis, in a cohort of patients with proximal gastric and esophagogastric junction cancer.
Decellularized umbilical cord wrapped with conductive hydrogel for peripheral nerve regeneration
Authors: Zhang Bin , Zhang Hui , Hu Yangnan , Tian Lei , Cheng Hong , Wang Yusong , Gao Xin , Cui Qingyue , Zheng Shasha , Feng Pan , Bian Feika , Wang Yu , Liu Tingting , Zhang Chen , Chai Renjie 
Published: October 2024

AbstractNerve guidance conduits have demonstrated great promise for the restoration of injured peripheral nerves in recent decades. Associated research has focused on improving the structure and function of these conduits as well as simplifying the manufacturing processes. Herein, a novel decellularized umbilical cord (DUC) wrapped with conductive hydrogel is presented for peripheral nerve regeneration, which is prepared by integrating the DUC matrix into a methacrylate gelatin (GelMA)/Ti3C2Tx MXene (MXene) composite hollow conduit (named DUC–MXene–GelMA conduit). The obtained DUC–MXene–GelMA conduit displays superior mechanical properties, electrical conductivity, and biocompatibility. Particularly, ascribed to the introduction of DUC and MXene, the DUC–MXene–GelMA conduit exhibits satisfactory biological effects in promoting neuron growth and Schwann cell proliferation and migration. Through in vivo experiments using a rat sciatic nerve injury model, the beneficial effects of the DUC–MXene–GelMA conduit on axonal regeneration and motor function recovery are demonstrated. These findings indicate that the DUC–MXene–GelMA conduit may be a promising candidate for peripheral nerve injury repair.
Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting
Authors: Chour Mohamed , Porteu Françoise , Depil Stéphane , Alcazer Vincent 
Published: October 2024

AbstractEndogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode proteins, although most degenerated or served as a source for novel genes and regulatory elements during evolution. Despite ERE repression mechanisms developed to maintain genome stability, widespread pervasive ERE activation is observed in cancer including hematological malignancies. Challenging the perception of noncoding DNA as “junk,” EREs are underestimated contributors to cancer driver mechanisms as well as antitumoral immunity by providing innate immune ligands and tumor antigens. This review highlights recent progress in understanding ERE co‐option events in cancer and focuses on the controversial debate surrounding their causal role in shaping malignant phenotype. We provide insights into the rapidly evolving landscape of ERE research in hematological malignancies and their clinical implications in these cancers.
Oxytocin Verbindungen zur oralen Behandlung von Bauchschmerzen
Authors: Kremsmayr Thomas , Schober Gudrun , Kaltenböck Matthias , Hoare Bradley L. , Brierley Stuart M. , Muttenthaler Markus 
Published: October 2024

AbstractChronische Bauchschmerzen stellen für Millionen von Menschen, die an gastrointestinalen Erkrankungen wie dem Reizdarmsyndrom und entzündlichen Darmerkrankungen leiden, eine schwere Belastung dar. Der Oxytocin Rezeptor (OTR) ist ein neues therapeutisches Wirkstoffziel für die Entwicklung von Schmerzmittel: bei chronischer viszeraler Hypersensitivität ist die Expression von OTR auf vom Lumen aus zugänglichen Nozizeptoren im Dickdarm erhöht, was eine gezielte luminale Verabreichung von Liganden ermöglicht. Allerdings stellt die geringe gastrointestinale Stabilität des endogenen Peptidliganden Oxytocin (OT) ein Problem für die therapeutische Entwicklung dar. In dieser Studie, beschreiben wir die Entwicklung potenter und verdauungsstabiler OT‐Verbindungen, die den Grundstein für eine neue Wirkstoffklasse von oralen, darmspezifischen Peptidtherapeutika legen. Die Ligandenoptimierung, geleitet von Struktur‐Verdauungsstabilitäts‐Aktivitäts‐Beziehungen, ergab stabile Verbindungen (t1/2>24 h, im Vergleich zu t1/2<10 min für OT in Darmflüssigkeit), die equipotent wie OT (~3 nM) waren und verbesserte OTR‐Selektivität aufwiesen. Die rektale Verabreichung der besten Leitverbindung zeigte konzentrationsabhängig schmerzstillende Effekte in einem chronischen Bauchschmerz Mausmodel. Auch die orale Verabreichung dieser Leitverbindung zeigte signifikante analgetische Effekte. Die entwickelten Verbindungen und die angewandten Strategien könnten den Weg für eine neue Klasse oraler, darmspezifischer Peptide ebnen, um chronische gastrointestinale Erkrankungen zu erforschen und zu bekämpfen – ein Bereich mit erheblichem ungedecktem medizinischem Bedarf.
Tailoring d‐Band Center of Single‐Atom Nickel Sites for Boosted Photocatalytic Reduction of Diluted CO2 from Flue Gas
Authors: Liu Jiahui , Han Bin , Liu Xueming , Liang Shujie , Fu Yang , He Jun , Chung Lai‐Hon , Lin Yuanfang , Wei Yupeng , Wang Sibo , Ma Tianyi , Yang Zhifeng 
Published: October 2024

AbstractPhotocatalytic reduction of diluted CO2 from anthropogenic sources holds tremendous potential for achieving carbon neutrality, while the huge barrier to forming *COOH key intermediate considerably limits catalytic effectiveness. Herein, via coordination engineering of atomically scattered Ni sites in conductive metal–organic frameworks (CMOFs), we propose a facile strategy for tailoring the d‐band center of metal active sites towards high‐efficiency photoreduction of diluted CO2. Under visible‐light irradiation in pure CO2, CMOFs with Ni‐O4 sites (Ni‐O4 CMOFs) exhibits an outstanding rate for CO generation of 13.3 μmol h−1 with a selectivity of 94.5 %, which is almost double that of its isostructural counterpart with traditional Ni‐N4 sites (Ni‐N4 CMOFs), outperforming most reported systems under comparable conditions. Interestingly, in simulated flue gas, the CO selectivity of Ni‐N4 CMOFs decreases significantly while that of Ni‐O4 CMOFs is mostly unchanged, signifying the supremacy for Ni‐O4 CMOFs in leveraging anthropogenic diluted CO2. In situ spectroscopy and density functional theory (DFT) investigations demonstrate that O coordination can move the center of the Ni sites′ d‐band closer to the Fermi level, benefiting the generation of *COOH key intermediate as well as the desorption of *CO and hence leading to significantly boosted activity and selectivity for CO2‐to‐CO photoreduction.
Electrochemical Performance of a New Triazole Functionalized Ferrocene in Aqueous Redox Flow Batteries
Authors: Eken Taha Yasin , Gonzalez Gabriel , Peljo Pekka , Koz Gamze 
Published: October 2024

ABSTRACTA new 1,2,3‐triazole functionalized ferrocene (1,2,3‐TAFc) produced by Cu(I)‐catalyzed click reaction was investigated as positive electrolyte for aqueous organic flow batteries (AOFBs). The molecule is highly soluble in 1 M hydrochloric acid and displays high electrochemical reversibility. 1,2,3‐TAFc demonstrated good stability during cycling with a low capacity decay (0.011%/cyc, 3.0%/day) and high Coulombic efficiency (99.4%) over 280 cycles when tested in a flow battery at low concentration. This low capacity decay was attributed to the instability of ferrocene. These findings indicate that a stable and water‐soluble catholyte for AOFBs can be obtained with structural modifications of 1,2,3‐TAFc.
Dauerhafte und nachhaltige Brückenkappen aus nichtmetallischer Bewehrung und Recyclingbeton
Authors: Görtz Stephan , Lengert Kay , Glomb Daniel , Kustermann Andrea , Dauberschmidt Christoph , Burgard Stefan 
Published: October 2024

AbstractAufgrund chloridinduzierter Korrosion müssen Brückenkappen aus Stahlbeton regelmäßig bzw. vielfach häufiger als geplant erneuert werden. Im Rahmen eines vom Bundesministerium für Wirtschaft und Klimaschutz geförderten ZIM‐Projekts wurden Brückenkappen aus einer nichtmetallischen Basaltfaserstabbewehrung und einem Recyclingbeton entwickelt, sodass die Schwachstelle der Korrosion entschärft wird und die Materialien im Hinblick auf den Materialkreislauf zugleich besser ausgenutzt werden. Hierzu wurden gebogene Bewehrungselemente aus chloridunempfindlicher Basaltfaserstabbewehrung sowie ein Beton mit hohem Frost‐Tausalz‐Widerstand entwickelt, der aus bis zu 100 % recyclierter Gesteinskörnung besteht. Alle Teilentwicklungen wurden zu einem ganzheitlichen Ansatz vereint und ein Prototyp einer ressourcenschonenden und dauerhaften Brückenkappe erfolgreich hergestellt und getestet.
Enhancing competitiveness and sustainability in Spanish agriculture: The role of technological innovation and corporate social responsibility
Authors: Abad‐Segura Emilio , Castillo‐Díaz Francisco José , Batlles‐delaFuente Ana , Belmonte‐Ureña Luis J. 
Published: October 2024

AbstractThis study explores the integration of sustainable technological innovation (STI) and corporate social responsibility (CSR) within the Spanish agricultural sector, aiming to enhance competitiveness and sustainability. Departing from previous research that often underrepresents the unique dynamics of this sector, our analysis employs both theoretical frameworks and empirical data to assess the interplay between STI and CSR. We develop a composite CSR indicator and analyze its association with regional R&D + i investment across Spain. Findings indicate that STI adoption, particularly in precision agriculture and smart livestock management, significantly enhances CSR outcomes by optimizing resource utilization and minimizing environmental impact. However, notable regional disparities emerge, influenced by economic resources, infrastructure, and policy environments. This study contributes to the literature by elucidating the role of STI in fostering sustainable agricultural practices and underscores the necessity for targeted policy interventions to support regions lagging in CSR performance. The results advocate for integrating technological innovation with CSR strategies to ensure long‐term sustainability and competitiveness in the agricultural sector.
Critical appraisal of Genelyn soft embalming for cadaveric surgical skill training: A systematic review
Authors: Rajasekhar S. S. S. N. , Kaliyamoorthy Kalaivani , Dinesh Kumar V. , Sivadasan Neethu 
Published: October 2024

AbstractGenelyn is a proprietary embalming solution used for preserving cadavers for surgical skill training (SST) and undergraduate teaching. The aim of this review is to examine the Genelyn embalming method critically by analyzing scientific publications that have employed this method for SST and undergraduate education. The systematic review process involved searching for all relevant articles in PubMed, Google Scholar, and Embase using the keywords “Genelyn,” Genelyn embalming,” “Genelyn embalmed cadaver,” and “surgical skill training. All studies on Genelyn embalming published up to August 14, 2024, in the English language were eligible for inclusion. The literature review yielded 92 studies, 43 of which met the inclusion criteria. The Anatomical Quality Assurance (AQUA) tool from the International Evidence‐Based Anatomy (iEBA) working group was used to assess and analyze the risk of bias in all the selected full‐text articles. The selected studies reported that Genelyn embalming provided life‐like joint range of motion, tissue pliability, and color. Cadaveric studies assessing embalming solutions typically had smaller sample sizes, and few of them compared Genelyn embalmed cadavers (GECs) with the other soft embalming solutions. Unlike Theil's embalming, Genelyn embalming is cost‐effective, with easy steps for the preparation and storage of the solution and convenient handling of cadavers. Therefore, GECs serve as an efficient tool for SSTs.
Optimal Sequence for Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: An Evidence‐Based Review
Authors: Ghalehtaki Reza , Nourbakhsh Forouzan , Abyaneh Romina , Sharifian Azadeh , Pashapour‐Khoyi Sheyda , Aghili Mahdi , Gambacorta Maria Antonietta , Couñago Felipe 
Published: October 2024

ABSTRACTIntroductionHistorically, multimodal therapeutic strategies involving preoperative chemoradiotherapy (CRT), surgery, and adjuvant chemotherapy (CT) have been employed to treat locally advanced rectal cancer (LARC). Total Neoadjuvant Therapy (TNT) is showing promise in improving outcomes. Despite its benefits, the optimal sequencing within TNT—whether induction chemotherapy should precede or follow chemoradiotherapy—remains a critical question. This study endeavors to explore the effects of different TNT sequencing strategies on patient outcomes, including tumor downstaging, pathological response, organ preservation, and the balance between efficacy and tolerability.MethodsOur methodology entailed a comprehensive literature review conducted on Medline, focusing on recent research, including retrospective studies, systematic reviews, and clinical trials. The review emphasized the comparison of induction chemotherapy versus consolidation chemotherapy within TNT regimens, assessing outcomes such as pathological response, organ preservation rates, and adverse effects. To ensure the selection of appropriate and high‐quality studies, specific inclusion and exclusion criteria were applied.ResultsThe analysis revealed that induction chemotherapy might lead to decreased adherence to subsequent chemoradiotherapy while offering an early intervention against micrometastasis and potentially improving overall chemotherapy compliance. Conversely, consolidation chemotherapy has been associated with higher pathological complete response (pCR) rates and improved tolerability, indicating its potential for patients requiring local symptom relief or those eligible for a nonoperative management approach. Comparative studies like CAO/ARO/AIO‐12 and the OPRA trials have significantly contributed to our understanding, suggesting that while both strategies have distinct advantages, the choice between induction and consolidation chemotherapy should be tailored based on individual patient profiles and tumor characteristics.ConclusionThis narrative review underscores the importance of a nuanced approach to TNT sequencing in locally advanced rectal cancer, highlighting the need for further research to refine treatment strategies.
Microcatheter tip fracture and acute vessel occlusion rescued with subintimal tracking and re‐entry: Move the tip
Authors: Francesco Giangiacomi , Luca Mircoli , Gabriele Tumminello , Stefano Carugo 
Published: October 2024

AbstractThe development of microcatheters capable of advancing through long, calcified, and tortuous vessels, produced an increase in the success rate of complex percutaneous coronary interventions. However, the aggressive manipulation of these materials may lead to potentially severe and threatening complications. We present a case of Turnpike Spiral (Teleflex) tip fracture, which caused an acute occlusion of the proximal right coronary artery. The coronary artery was tortuous and had two heavily calcified lesions in the proximal segment, uncrossable to both small angioplasty balloons and standard microcatheters. After the incarceration of the tip of the Turnpike Spiral in the calcium, it got fractured during the attempt of removing it from the vessel. This led to ST‐segment elevation and patient instability. Due to the impossibility of advancing a second guidewire into the true lumen, we decided to proceed to antegrade dissection and re‐entry using the scratch‐and‐go and subintimal tracking and re‐entry technique. We placed a guide‐extension and we used a Gaia II (Asahi Intecc) to enter the subintimal space and advance over the fractured tip. The wire was exchanged for a Gladius MG (Asahi Intecc), which re‐entered the true lumen at the level of the acute margin of the heart. Intravascular ultrasound was used to confirm the re‐entry point, and three drug eluting stents were placed. In this way we rapidly restored the flow in the right coronary artery, and we prevented a myocardial infarction.
Image‐based quality control of fresh concrete based on semantic segmentation algorithms
Authors: Schack Tobias , Coenen Max , Haist Michael 
Published: October 2024

AbstractIn practice, various empirical methods such as the flow table test or the slump test are in use worldwide for assessing the workability of fresh concrete on the construction site. The majority of these tests has in common, that fresh concrete is subjected to some kind of defined flow process on a standardized table‐like platform and that the geometrical properties of the material after the flow has ceased is determined by simple means such as measuring the flow cake diameter or its sag. The paper at hand proposes a novel image‐based approach for an automatic derivation of concrete properties as part of the flow table test. The image‐based method enables a digital evaluation of concrete properties. By combining digital image analysis and deep learning methods, not only the consistency but also an abundance of additional concrete properties can be derived from image data. In this way, the quality control of the fresh concrete can be expanded to include a large number of additional parameters, currently not available to the producer nor to the construction site. This data can be integrated into a digital control loop, with which communication between the concrete producer and the construction site can be automated using highly precise real‐time data.
The Spanish Society of Medicinal Chemistry: Promoting Pharmaceutical R&D in Spain since 1977
Authors: Bartolomé‐Nebreda José‐Manuel , de Pascual‐Teresa Beatriz , Gutiérrez‐Rodríguez Marta , Martín‐Martínez Mercedes 
Published: October 2024

AbstractThe Spanish Society of Medicinal Chemistry (Sociedad Española de Química Terapéutica SEQT), founded in 1977, aims to advance pharmaceutical research and education in Spain, collaborating with academia, industry, and public entities. It was initially linked with the Institute of Medicinal Chemistry from Spanish National Research Council (IQM‐CSIC), emphasizing the independence of medicinal chemistry as a discipline. SEQT′s presidency rotates between representatives from universities, research institutes, and industry, ensuring diverse perspectives. With around 500 members, SEQT represents sectors including universities, CSIC, and industry, with a notable presence of early‐career researchers. The Society actively participates in the European Federation for Medicinal chemistry and Chemical biology (EFMC). SEQT organizes conferences, summer schools, and mini symposia to facilitate networking and knowledge exchange among professionals. To support early‐career scientists, SEQT organizes symposia and awards, recognizing achievements in drug discovery. It fosters mentorship opportunities and engages with international networks like EFMC‐YSN. In 2023, SEQT established its Early Career Scientist (SEQT‐ECS) group to provide tailored support and resources. With over 40 years of experience, SEQT continues to evolve, embracing social media and adapting to changes in medicinal chemistry and chemical biology. It remains committed to supporting its members and advancing research to address human health challenges.
Biomechanics of the Human Knee Joint in Maximum Voluntary Isometric Flexion: Study of Changes in Applied Moment, Agonist–Antagonist Participations, Joint Center, and Flexion Angle
Authors: Salehi Pooya , Shirazi‐Adl Aboulfazl , Ghezelbash Farshid 
Published: October 2024

ABSTRACTEstimation of the knee joint strength by maximum voluntary isometric contraction (MVIC) is a common practice to assess strength, coordination, safety to return to work or engage in sports after an injury, and to evaluate the efficacy of treatment modalities and rehabilitation strategies. In this study, we utilize a previously validated coupled finite element‐musculoskeletal model of the lower extremity to explore the sensitivity of output measures (posterior cruciate ligament [PCL]/muscle/contact forces and passive moments) in knee MVIC flexion exercises at seated position. To do so, at three knee flexion angles (KFA), input measures (resistance moment and contribution moments of quadriceps and gastrocnemii) were varied at four levels each using the Taguchi design of experiment. Our findings reveal significant increases in PCL forces with KFA (p < 0.01), net MVIC moment (p < 0.01), and resistance moment of quadriceps (p < 0.01). In contrast, they drop at larger activity in gastrocnemii (p < 0.01). Tibiofemoral (TF) contact forces increase with the net MVIC moment (p < 0.01). The passive knee flexion moment, while highly dependent on the location at which computed, also increases with the net MVIC moment (p < 0.01). Changes in KFA, MVIC moment, and proportions thereof carried by quadriceps and/or gastrocnemii substantially affect biomechanics of the joint. Compared with level walking and stair ascent, slightly larger contact forces/stresses and much greater PCL forces are computed. This study improves our understanding of the knee joint behavior during MVIC in effective evaluation and rehabilitation interventions. Besides, it emphasizes the importance of positioning the joint center in model studies.