bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using portable XRF to infer adularia halos within the Waihi Au-Ag system, New Zealand
Authors: Hughes Rosie , Barker Shaun L. L. 
Published: August 2017

Waihi Au-Ag mineralization is vein hosted within a relatively homogeneous andesite body. Geochemical exploration targets adularia and pathfinder (As, Sb, Hg etc.) anomalies. Adularia is formed as an alteration product of feldspars during hydrothermal alteration and occurs in anomalous concentrations near Au-Ag mineralization. This paper aims to test the potential of portable X-ray fluorescence (pXRF) to infer and map adularia and As anomalies. The pXRF was first tested on standards (CRM and ILD), it yielded accurate and precise data for most of the elements of interest (r
2
> 0.9 and APD < 10%). The second stage applied the pXRF directly on core, most elements were negatively affected, but still to a usable degree of accuracy. As was particularly effected due to its heterogeneous distribution (APD 46%). Lastly, we applied the pXRF to a suite of 300 Favona samples, their K/Al value were used as a proxy for adularia presence. XRD analysis carried out on 60 samples was used to validate adularias presence or absence. When combined with pXRF data we found a K/Al value above 0.4 generally indicated a sample contained adularia. Therefore, with further work, the pXRF could be independently used to infer adularia alteration in the Waihi setting.
Face percept formation in human ventral temporal cortex
Authors: Miller Kai J. , Hermes Dora , Pestilli Franco , Wig Gagan S. , Ojemann Jeffrey G. 
Published: August 2017

Loci in ventral temporal cortex are selectively active during viewing of faces and other objects, but it remains unclear whether these areas represent accumulation of simple visual information or processing of intact percept. We measured broadband electrocorticographic changes from implanted electrodes on the ventral temporal brain surface while showing patients noise-degraded images of faces and houses. In a subset of posterior fusiform gyrus face-selective regions, cortical activity decreased parametrically with noise increase, until the perceptual threshold was surpassed. At noise levels higher than the perceptual threshold, and for house stimuli, activity remained at baseline. We propose that this convergence of proportional and thresholded response may identify active areas where face percepts are extracted from simple visual features. These loci exist within a topological structure of face percept formation in the human ventral visual stream, preceded by category-nonselective activity in pericalcarine early visual areas and in concert with all-or-nothing activity in postperceptual subregions of the ventral temporal lobe. This topological organization suggests a physiological basis for the anatomy of face perception, explaining different perceptual deficits following temporal lobe injury. NEW & NOTEWORTHY Philosophers have puzzled for millennia about how humans build abstract conceptual objects (house/face/tool) from the simple features of the world they see around them (line/patch/lighting). Understanding the biological foundation of this process requires detailed knowledge of the spatial-temporal characteristics of cerebral cortex. By examining the physiology of the human temporal lobe via implanted electrodes while showing subjects noise-degraded images, we find that face percept formation happens in specific subregions within known face-processing areas.
Switching to Aflibercept in Diabetic Macular Edema Not Responding to Ranibizumab and/or Intravitreal Dexamethasone Implant
Authors: Herbaut Antoine , Fajnkuchen Franck , Qu-Knafo Lise , Nghiem-Buffet Sylvia , Bodaghi Bahram , Giocanti-Auregan Audrey 
Published: August 2017

Purpose. To assess short-term functional and anatomical outcomes of refractory diabetic macular edema (DME) following a switch from ranibizumab or dexamethasone to aflibercept. Methods. We included retrospectively eyes with persistent DME after at least 3 ranibizumab and/or one dexamethasone implant intravitreal injections (IVI). The primary endpoint was the mean change in visual acuity (VA) at month 6 (M6) after switching. Results. Twenty-five eyes were included. Before switching to aflibercept, 23 eyes received a median of 9.5 ranibizumab, and among them, 6 eyes received one dexamethasone implant after ranibizumab and 2 eyes received only one dexamethasone implant. Baseline VA, before any IVI, was 52.9 ± 16.5 letters, and preswitch VA was 57.1 ± 19.6 letters. The mean VA gain was +8 letters (p=0.01) between preswitch and M6. The mean central retinal thickness was 470.8 ± 129.9 μm before the switch and 303.3 ± 59.1 μm at M6 (p=0.001). Conclusion. Switching to aflibercept in refractory DME results in significant functional and anatomical improvement. The study was approved by the France Macula Federation ethical committee (FMF 2017-138).
De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Authors: Tadros Saber , Shukla Surendra K. , King Ryan J. , Gunda Venugopal , Vernucci Enza , Abrego Jaime , Chaika Nina V. , Yu Fang , Lazenby Audrey J. , Berim Lyudmyla , Grem Jean , Sasson Aaron R. , Singh Pankaj K. 
Published: August 2017

Abstract
Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single-agent therapy for pancreatic cancer. Although the prognosis in pancreatic cancer remains grim in part due to poor response to therapy, previous attempts at identifying and targeting the resistance mechanisms have not been very successful. By leveraging The Cancer Genome Atlas dataset, we identified lipid metabolism as the metabolic pathway that most significantly correlated with poor gemcitabine response in pancreatic cancer patients. Furthermore, we investigated the relationship between alterations in lipogenesis pathway and gemcitabine resistance by utilizing tissues from the genetically engineered mouse model and human pancreatic cancer patients. We observed a significant increase in fatty acid synthase (FASN) expression with increasing disease progression in spontaneous pancreatic cancer mouse model, and a correlation of high FASN expression with poor survival in patients and poor gemcitabine responsiveness in cell lines. We observed a synergistic effect of FASN inhibitors with gemcitabine in pancreatic cancer cells in culture and orthotopic implantation models. Combination of gemcitabine and the FASN inhibitor orlistat significantly diminished stemness, in part due to induction of endoplasmic reticulum (ER) stress that resulted in apoptosis. Moreover, direct induction of ER stress with thapsigargin caused a similar decrease in stemness and showed synergistic activity with gemcitabine. Our in vivo studies with orthotopic implantation models demonstrated a robust increase in gemcitabine responsiveness upon inhibition of fatty acid biosynthesis with orlistat. Altogether, we demonstrate that fatty acid biosynthesis pathway manipulation can help overcome the gemcitabine resistance in pancreatic cancer by regulating ER stress and stemness. Cancer Res; 77(20); 5503–17. ©2017 AACR.
Topically Applied Carvedilol Attenuates Solar Ultraviolet Radiation Induced Skin Carcinogenesis
Authors: Huang Kevin M. , Liang Sherry , Yeung Steven , Oiyemhonlan Etuajie , Cleveland Kristan H. , Parsa Cyrus , Orlando Robert , Meyskens Frank L. , Andresen Bradley T. , Huang Ying 
Published: August 2017

Abstract
In previous studies, the β-blocker carvedilol inhibited EGF-induced epidermal cell transformation and chemical carcinogen-induced mouse skin hyperplasia. As exposure to ultraviolet (UV) radiation leads to skin cancer, the present study examined whether carvedilol can prevent UV-induced carcinogenesis. Carvedilol absorbs UV like a sunscreen; thus, to separate pharmacological from sunscreen effects, 4-hydroxycarbazole (4-OHC), which absorbs UV to the same degree as carvedilol, served as control. JB6 P+ cells, an established epidermal model for studying tumor promotion, were used for evaluating the effect of carvedilol on UV-induced neoplastic transformation. Both carvedilol and 4-OHC (1 μmol/L) blocked transformation induced by chronic UV (15 mJ/cm2) exposure for 8 weeks. However, EGF-mediated transformation was inhibited by only carvedilol but not by 4-OHC. Carvedilol (1 and 5 μmol/L), but not 4-OHC, attenuated UV-induced AP-1 and NF-κB luciferase reporter activity, suggesting a potential anti-inflammatory activity. In a single-dose UV (200 mJ/cm2)-induced skin inflammation mouse model, carvedilol (10 μmol/L), applied topically after UV exposure, reduced skin hyperplasia and the levels of cyclobutane pyrimidine dimers, IL1β, IL6, and COX-2 in skin. In SKH-1 mice exposed to gradually increasing levels of UV (50–150 mJ/cm2) three times a week for 25 weeks, topical administration of carvedilol (10 μmol/L) after UV exposure increased tumor latency compared with control (week 18 vs. 15), decreased incidence and multiplicity of squamous cell carcinomas, while 4-OHC had no effect. These data suggest that carvedilol has a novel chemopreventive activity and topical carvedilol following UV exposure may be repurposed for preventing skin inflammation and cancer. Cancer Prev Res; 10(10); 598–606. ©2017 AACR.
The Gallic Ransom and the Sack of Rome
Authors: Roth Ulrike 
Published: August 2017

AbstractThe article challenges the widespread view that the Gallic ransom mentioned in a number of sources for the events traditionally known as the Sack of Rome in 390BCshould be understood as evidence that the Gauls did not take Rome in its entirety. The article shows in contrast that, whatever happened in the night when the geese suffered from insomnia on the Capitoline Hill, a ransom is a perfectly suitable element in a story of a Gallic take-over of Rome—hill and all; and that it cannot be taken as evidence that an alternative narrative to the successful defence of the Capitoline Hill never existed.
Eros dans l’anthroponymie grecque
Authors: Striano Araceli 
Published: August 2017

Abstract
The history of Greek personal names (PN) related to the theonym Eros is striking.1 Despite being one of the most important gods, Eros, along with Aphrodite, is largely absent from Greek proper names in the archaic and classical periods. Later, however, and especially under Rome, there is a remarkable increase in PN at Rome and Pompeii, as well as in Hispania. The reason for the absence of Eros in early Greek names is most likely the sense of the Greek term ἔρως as ‘passionate love’, whereas its increased popularity in Hellenistic and Roman times reflects the more genial representation of the god of love in statues and reliefs.
What’s in a #Name? An Experimental Study Examining Perceived Credibility and Impact of Winter Storm Names
Authors: Rainear Adam M. , Lachlan Kenneth A. , Lin Carolyn A. 
Published: August 2017

Abstract
The practice of naming winter storms has generated a large amount of discussion within the meteorology community of late. While storm naming has typically been reserved for tropical systems, some media organizations in the United States recently began naming winter storms but oftentimes using differing criteria. Anecdotal comments have labeled this practice as a marketing initiative and other forecasting organizations have criticized The Weather Channel for naming storms (Palmer), but little to no research has investigated whether naming winter storms serves useful to forecasters, practitioners, and the general public. The purpose of this study is twofold. First, the hope is to further the discussion and investigation of naming winter storms. This study provides empirical evidence that suggests that little difference exists between individual perceptions dependent on whether a name is used or the type of name used. The results indicate that individuals do not differ in levels of perceived severity or susceptibility toward a fictional winter storm dependent on the type of name used. Similarly, perceptions of the credibility of media organizations do not change dependent on the storm name. Second, this study discusses the implications of the results with respect to the current storm naming process and provide future areas of exploration, which can further an understanding of the practice.
Transitioning From Paper to Digital: State Statutory and Regulatory Frameworks for Health Information Technology
Authors: Schmit Cason , Sunshine Gregory , Pepin Dawn , Ramanathan Tara , Menon Akshara , Penn Matthew 
Published: August 2017

Objectives: In all health system sectors, electronic health information (EHI) is created, used, released, and reused. We examined states’ efforts to address EHI uses in law to provide an understanding of the EHI legal environment. Methods: Attorney researchers used WestlawNext to search for EHI-related statutes and regulations of the US states, US territories, and the District of Columbia in effect as of January 2014. The researchers independently catalogued provisions by the EHI use described in the law. Researchers resolved discrepancies through peer review meetings and recorded the consensus codes for each law. Results: This study identified 2364 EHI-related laws representing 49 EHI uses in 54 jurisdictions. A total of 18 EHI uses were regulated by ≥10 jurisdictions. More than 750 laws addressed 2 or more EHI uses. Jurisdictions varied by the number of EHI laws in effect, with a mean of 44 laws. Texas had the most EHI laws (n = 145). Hawaii and South Carolina had the fewest (n = 14 each). Conclusions: The EHI legal landscape is complex. The large quantity and diversity of laws complicate legal analysis, likely delay implementation of public health solutions, and might be detrimental to the development of emerging health information technology. Research is needed to understand the effect of EHI-related laws.
Phase of Illness in palliative care: Cross-sectional analysis of clinical data from community, hospital and hospice patients
Authors: Mather Harriet , Guo Ping , Firth Alice , Davies Joanna M , Sykes Nigel , Landon Alison , Murtagh Fliss EM 
Published: August 2017

Background: Phase of Illness describes stages of advanced illness according to care needs of the individual, family and suitability of care plan. There is limited evidence on its association with other measures of symptoms, and health-related needs, in palliative care. Aims: The aims of the study are as follows. (1) Describe function, pain, other physical problems, psycho-spiritual problems and family and carer support needs by Phase of Illness. (2) Consider strength of associations between these measures and Phase of Illness. Design and setting: Secondary analysis of patient-level data; a total of 1317 patients in three settings. Function measured using Australia-modified Karnofsky Performance Scale. Pain, other physical problems, psycho-spiritual problems and family and carer support needs measured using items on Palliative Care Problem Severity Scale. Results: Australia-modified Karnofsky Performance Scale and Palliative Care Problem Severity Scale items varied significantly by Phase of Illness. Mean function was highest in stable phase (65.9, 95% confidence interval = 63.4–68.3) and lowest in dying phase (16.6, 95% confidence interval = 15.3–17.8). Mean pain was highest in unstable phase (1.43, 95% confidence interval = 1.36–1.51). Multinomial regression: psycho-spiritual problems were not associated with Phase of Illness ( χ2 = 2.940, df = 3, p = 0.401). Family and carer support needs were greater in deteriorating phase than unstable phase (odds ratio (deteriorating vs unstable) = 1.23, 95% confidence interval = 1.01–1.49). Forty-nine percent of the variance in Phase of Illness is explained by Australia-modified Karnofsky Performance Scale and Palliative Care Problem Severity Scale. Conclusion: Phase of Illness has value as a clinical measure of overall palliative need, capturing additional information beyond Australia-modified Karnofsky Performance Scale and Palliative Care Problem Severity Scale. Lack of significant association between psycho-spiritual problems and Phase of Illness warrants further investigation.
A Microcosting Study of Establishing a Baby Café® in Texas
Authors: Delgado Rigoberto I. , Gill Sara L. 
Published: August 2017

Background: This article focuses on the costs of opening and running a Baby Café. A Baby Café is an intervention that focuses on providing peer-to-peer support for breastfeeding mothers. Research aim: This study aimed to estimate the costs of establishing and running a Baby Café. Methods: The authors used a microcosting approach to identifying costs using the case of a Baby Café located in San Antonio, Texas, and modeled after other existing cafés in the United States. They also used extensive literature review and conducted an informal interview with a manager of an existing Baby Café in the United States to validate our cost data. The cost analysis was done from the provider perspective. Results: Costs of starting a Baby Café were $36,000, whereas annual operating costs totaled $47,000. Total discounted costs for a 5-year period amounted to $250,000, resulting in a cost per Baby Café session of $521 and cost per mother of $104. Varying the number of sessions per week and number of mothers attending each session, the discounted cost per Baby Café session ranged between $460 and $740 and the cost per mother varied between $65 and $246. Conclusion: These findings can be used by policy makers and organizations to evaluate local resource requirements for starting a Baby Café. Further research is needed to evaluate the effectiveness of this intervention against other breastfeeding promoting initiatives.
Qualitative Analysis of Registered Nurses’ Perceptions of Lactation Assessment Tools: Why and How They Are Completed
Authors: Kuhnly Joan Esper , Chapman Donna J. 
Published: August 2017

Background: Although lactation assessment tools are consistently used in clinical practice, there is no evidence describing registered nurses’ perspectives regarding the purpose and thought processes involved when conducting a breastfeeding assessment. Research aim: This study aimed to explore registered nurses’ perceptions on the purpose of lactation assessment tools and the thought processes involved in completing one. Methods: Seven focus groups were held from April 2015 through July 2015, in coordination with regional and international lactation and perinatal conferences. Participants included 28 hospital-based registered nurses who routinely used a lactation assessment tool to assess postpartum mothers with healthy breastfeeding newborns. Focus groups were audiotaped, transcribed verbatim, and content analyzed by two lactation researchers to identify relevant themes and subthemes. Results: The analyses identified four different purposes of breastfeeding assessment tools (Teaching and Assessing Simultaneously, Infant Safety, Standardized Practice, and “It’s Your Job!”) and four themes related to the thought processes used in completing the tool (Novice vs. Expert, Real-Time vs. Recalled Documentation, Observation or Not, and “Fudging the Score”). Conclusion: Registered nurses found lactation assessment tool completion to be an essential part of their job and that it ensured infant safety, standardized care, maternal instruction, and lactation assessment. Differences in the lactation assessment tool completion process were described, based on staff expertise, workload, hospital policies, and varying degrees of compliance with established protocols. These findings provide critical insight for the development of future breastfeeding assessment tools.
A concept analysis of professional commitment in nursing
Authors: García-Moyano Loreto , Altisent Rogelio , Pellicer-García Begoña , Guerrero-Portillo Sandra , Arrazola-Alberdi Oihana , Delgado-Marroquín María Teresa 
Published: August 2017

Background: The concept of professional commitment is being widely studied at present. However, although it is considered an indicator for the most human part of nursing care, there is no clear definition for it, and different descriptors are being used indiscriminately to reference it. Objective: The aim of this study is to clarify the concept of professional commitment in nursing through the Rodgers’ evolutionary concept analysis process. Design: Systematic search using English and Spanish descriptors and concept analysis. Studies published between 2009 and June 2015, front-to-back analysis of the Nursing Ethics journal and manual check of articles cited in studies related to the Nijmegen Professionalism Scale. Research design: The procedure of concept analysis developed by Rodgers was used. Ethical considerations: Although the topic was not labeled as sensitive and subject to ethical approval, its realization was approved by the Ethical Committee of Clinical Research of Aragon (CEICA) approved the study on 18 March 2015 and also careful procedures have been followed according to ethics expressed in the Declaration of Helsinki. Findings and discussion: A total of 17 published studies. A clear definition of the concept was made, and surrogate terms, concept dimension, differential factors related to the concept, sociocultural variations and consequences for nursing practice were identified. Conclusion: There is a need for continuous advancement in the development of the concept, specific actions to encourage this and the improvement of evaluation methods for its study.
Hindfoot Arthritis Progression and Arthrodesis Risk After Total Ankle Replacement
Authors: Dekker Travis J. , Walton David , Vinson Emily N. , Hamid Kamran S. , Federer Andrew E. , Easley Mark E. , DeOrio James K. , Nunley James A. , Adams Samuel B. 
Published: August 2017

Background: The purpose of this study was to assess the radiographic progression of subtalar and talonavicular degenerative joint disease in a series of patients who had undergone TAA (total ankle arthroplasty) with minimum follow-up of 5 years. Methods: TAA patient radiographs from a single institution were analyzed for peritalar arthritic changes by extrapolating the modified Kellgren Lawrence (KL) grades of the knee to the subtalar and talonavicular joints. Patients were included if they had a minimum of 5 years of follow-up. Patients who had undergone prior arthrodesis of the talonavicular or subtalar joints were excluded. A total of 140 patients with average follow-up of 6.5 years (range, 5.0-8.9 years) were included. Results: Overall, 27% of patients advanced 1 KL grade at the subtalar joint and 31% of patients increased 1 KL grade at the talonavicular joint. Furthermore, 60% and 66% of patients showed no progression in the subtalar and talonavicular joints, respectively. Two patients progressed greater than 2 KL subtalar arthritis grades and only 2 patients with talonavicular arthritis progressed to the same extent. Sixteen patients went on to require a subtalar arthrodesis compared to 2 requiring a talonavicular fusion ( P < .05). Conclusion: This study suggests a moderate but nominal radiographic increase in adjacent subtalar and talonavicular arthritis over a minimum of 5 years after TAA. Future studies require a comparative control group of ankle fusion, but these data may suggest the motion preserved with an arthroplasty diminishes the stresses and compensatory motion incurred during tibiotalar arthrodesis. Level of Evidence: Level IV, retrospective case series.