bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast and Minimal‐Solvent Production of Superinsulating Silica Aerogel Granulate
Authors: Huber Lukas , Zhao Shanyu , Malfait Wim J. , Vares Sirje , Koebel Matthias M. 
Published: March 2017

AbstractWith their low thermal conductivity (λ), silica aerogels can reduce carbon emissions from heating and cooling demands, but their widespread adoption is limited by the high production cost. A one‐pot synthesis for silica aerogel granulate is presented that drastically reduces solvent use, production time, and global warming potential. The inclusion of the hydrophobization agent prior to gelation with a post‐gelation activation step, enables a complete production cycle of less than four hours at the lab scale for a solvent use close to the theoretical minimum, and limits the global warming potential. Importantly, the one‐pot aerogel granulate retains the exceptional properties associated with silica aerogel, mostly λ=14.4±1.0 mW m−1⋅K−1 for the pilot scale materials, about half that of standing air (26 mW m−1⋅K−1). The resource‐, time‐, and cost‐effective production will allow silica aerogels to break out of its niche into the mainstream building and industrial insulation markets.
Iron(II)‐Catalyzed Hydrophosphination of Isocyanates
Authors: Sharpe Helen R. , Geer Ana M. , Lewis William , Blake Alexander J. , Kays Deborah L. 
Published: March 2017

AbstractThe first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low‐coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P−H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2PC(=O)N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds. This remarkable result can be attributed to the low‐coordinate nature of the iron(II) centers whose inherent electron deficiency enables a Lewis‐acid mechanism in which a combination of the steric pocket of the metal center and substrate size determines the reaction products and regioselectivity.
Elemental Boron for Efficient Carbon Dioxide Reduction under Light Irradiation
Authors: Liu Guigao , Meng Xianguang , Zhang Huabin , Zhao Guixia , Pang Hong , Wang Tao , Li Peng , Kako Tetsuya , Ye Jinhua 
Published: March 2017

AbstractThe photoreduction of CO2 is attractive for the production of renewable fuels and the mitigation of global warming. Herein, we report an efficient method for CO2 reduction over elemental boron catalysts in the presence of only water and light irradiation through a photothermocatalytic process. Owing to its high solar‐light absorption and effective photothermal conversion, the illuminated boron catalyst experiences remarkable self‐heating. This process favors CO2 activation and also induces localized boron hydrolysis to in situ produce H2 as an active proton source and electron donor for CO2 reduction as well as boron oxides as promoters of CO2 adsorption. These synergistic effects, in combination with the unique catalytic properties of boron, are proposed to account for the efficiency of the CO2 reduction. This study highlights the promise of photothermocatalytic strategies for CO2 conversion and also opens new avenues towards the development of related solar‐energy utilization schemes.
Multi‐shelled Hollow Metal–Organic Frameworks
Authors: Liu Wenxian , Huang Jijiang , Yang Qiu , Wang Shiji , Sun Xiaoming , Zhang Weina , Liu Junfeng , Huo Fengwei 
Published: March 2017

AbstractHollow metal–organic frameworks (MOFs) are promising materials with sophisticated structures, such as multiple shells, that cannot only enhance the properties of MOFs but also endow them with new functions. Herein, we show a rational strategy to fabricate multi‐shelled hollow chromium (III) terephthalate MOFs (MIL‐101) with single‐crystalline shells through step‐by‐step crystal growth and subsequent etching processes. This strategy relies on the creation of inhomogeneous MOF crystals in which the outer layer is chemically more robust than the inner layer and can be selectively etched by acetic acid. The regulation of MOF nucleation and crystallization allows the tailoring of the cavity size and shell thickness of each layer. The resultant multi‐shelled hollow MIL‐101 crystals show significantly enhanced catalytic activity during styrene oxidation. The insight gained from this systematic study will aid in the rational design and synthesis of other multi‐shelled hollow structures and the further expansion of their applications.
Hierarchical Corannulene‐Based Materials: Energy Transfer and Solid‐State Photophysics
Authors: Rice Allison M. , Fellows W. Brett , Dolgopolova Ekaterina A. , Greytak Andrew B. , Vannucci Aaron K. , Smith Mark D. , Karakalos Stavros G. , Krause Jeanette A. , Avdoshenko Stanislav M. , Popov Alexey A. , Shustova Natalia B. 
Published: March 2017

AbstractWe report the first example of a donor–acceptor corannulene‐containing hybrid material with rapid ligand‐to‐ligand energy transfer (ET). Additionally, we provide the first time‐resolved photoluminescence (PL) data for any corannulene‐based compounds in the solid state. Comprehensive analysis of PL data in combination with theoretical calculations of donor–acceptor exciton coupling was employed to estimate ET rate and efficiency in the prepared material. The ligand‐to‐ligand ET rate calculated using two models is comparable with that observed in fullerene‐containing materials, which are generally considered for molecular electronics development. Thus, the presented studies not only demonstrate the possibility of merging the intrinsic properties of π‐bowls, specifically corannulene derivatives, with the versatility of crystalline hybrid scaffolds, but could also foreshadow the engineering of a novel class of hierarchical corannulene‐based hybrid materials for optoelectronic devices.
Bioinspired Asymmetric Synthesis of Hispidanin A
Authors: Li Fuzhuo , Tu Qian , Chen Sijia , Zhu Lei , Lan Yu , Gong Jianxian , Yang Zhen 
Published: March 2017

AbstractThe first enantiospecific synthesis of hispidanin A (4), a dimeric diterpenoid from the rhizomes of Isodon hispida, was achieved with a longest linear sequence of 12 steps in 6.5 % overall yield. A key component is the use of the abundant and naturally occurring diterpenoids (+)‐sclareolide and (+)‐sclareol as starting materials, which enables the gram‐scale preparation of the key intermediates totarane (1) and s‐trans‐12E,14‐labdadien‐20,8β‐olide (2). Subsequently a thermal or an erbium‐catalyzed intermolecular Diels–Alder reaction of totarane (1) with labdadienolide (2) provide convergent and rapid access to the natural product hispidanin A (4). The synthetic studies have offered significant impetus for the efficient construction of these architecturally complex natural products.
Highly Branched Metal Alloy Networks with Superior Activities for the Methanol Oxidation Reaction
Authors: Cui Xun , Xiao Peng , Wang Jing , Zhou Ming , Guo Wenlong , Yang Yang , He Yanjie , Wang Zewei , Yang Yingkui , Zhang Yunhuai , Lin Zhiqun 
Published: March 2017

AbstractThree‐dimensional (3D) interconnected metal alloy nanostructures possess superior catalytic performance owing to their advantageous characteristics, including improved catalytic activity, corrosion resistance, and stability. Hierarchically structured Ni‐Cu alloys composed of 3D network‐like microscopic branches with nanoscopic dendritic feelers on each branch were crafted by a facile and efficient hydrogen evolution‐assisted electrodeposition approach. They were subsequently exploited for methanol electrooxidation in alkaline media. Among three hierarchically structured Ni‐Cu alloys with different Ni/Cu ratios (Ni0.25Cu0.75, Ni0.50Cu0.50, and Ni0.75Cu0.25), the Ni0.75Cu0.25 electrode exhibited the fastest electrochemical response and highest electrocatalytic activity toward methanol oxidation. The markedly enhanced performance of Ni0.75Cu0.25 eletrocatalyst can be attributed to its alloyed structure with the proper Ni/Cu ratio and a large number of active sites on the surface of hierarchical structures.
Catalytic Asymmetric N‐Alkylation of Indoles and Carbazoles through 1,6‐Conjugate Addition of Aza‐para‐quinone Methides
Authors: Chen Min , Sun Jianwei 
Published: March 2017

AbstractCatalytic asymmetric N‐alkylation of indoles and carbazoles represents a family of important but underdeveloped reactions. Herein, we describe a new organocatalytic strategy in which in situ generated aza‐para‐quinone methides are employed as the alkylating reagent. With the proper choice of a chiral phosphoric acid and an N‐protective group, the intermolecular C−N bond formation with various indole and carbazole nucleophiles proceeded efficiently under mild conditions with excellent enantioselectivity and functional‐group compatibility. Control experiments and kinetic studies provided important insight into the reaction mechanism.
Dopamine‐functionalized poly(vinyl alcohol) elastomer with melt processability and self‐healing properties
Authors: Li Fayong , Xia Hesheng 
Published: March 2017

ABSTRACTA dopamine‐functionalized poly(vinyl alcohol) (PVA) elastomer with melt processability and self‐healing properties was prepared by a new chemical route of graft modification, that is, PVA carboxylation and a carbodiimide reaction. The conventional modifier for PVA sacrificed the intrinsic hydrogen‐bonding interactions and dramatically decreased the mechanical strength. The modifier dopamine, as a catechol derivative, has two hydroxyl groups, which formed hydrogen bonds with the hydroxyl groups of PVA; it also has one benzene ring, which increased the thermal stability. We found that the introduction of dopamine into the PVA molecular structure lowered the melting point, improved the thermal stability, broke the crystalline structure, and enabled thermal processing. Moreover, the modified PVA possessed good mechanical properties, could be self‐healed, and is believed to have potential applications in many fields. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45072.
Vegetable fillers for electric stimuli responsive elastomers
Authors: Poikelispää Minna , Shakun Alexandra , Sarlin Essi , Das Amit , Vuorinen Jyrki 
Published: March 2017

ABSTRACTDielectric elastomer actuators (DEAs) have been studied widely in recent years for artificial muscle applications, but their implementation into production is limited due to high operating voltages required. The actuation behavior of dielectric elastomer under an applied electric field is predicted by Maxwell's pressure and thickness strain equations. According to these equations, the best electromechanical response is achieved when the relative permittivity is high and elastic modulus is low. The potential source for additives increasing the relative permittivity of rubbers can be vegetable powders that have much higher dielectric constant than common elastomers. In the present research, the dielectric and actuation properties of polyacrylate rubber (ACM) were studied after the addition of different vegetable‐based fillers such as potato starch, corn starch, garlic, and paprika. The results were compared to ACM filled with barium titanate. The compounds containing vegetable fillers showed higher relative dielectric permittivity at 1 Hz frequency than the compounds containing barium titanate due to higher interfacial polarization. The actuation studies showed that lower electric fields are required to generate certain actuation forces when the starches and garlic are used in the rubber instead of barium titanate. Therefore, the vegetable‐based fillers can be used to improve actuation performance of DEAs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45081.
Bifunctional Cage‐Type Cubic Mesoporous Silica SBA‐1 Nanoparticles for Selective Adsorption of Dyes
Authors: Lin Chien‐Hua , Deka Juti Rani , Wu Cheng‐En , Tsai Cheng‐Hsun , Saikia Diganta , Yang Yung‐Chin , Kao Hsien‐Ming 
Published: March 2017

AbstractBifunctional SBA‐1 mesoporous silica nanoparticles (MSNs) with carboxylic acid and amino groups (denoted as CNS‐10‐10) have been successfully synthesized, characterized, and employed as adsorbents for dye removal. Adsorbent CNS‐10‐10 shows high affinity towards cationic and anionic dyes in a wide pH range, and exhibits selective dye removal of a two‐dye mixture system of cationic methylene blue and anionic eosin Y. By changing the pH of the medium, the selectivity of the adsorption behavior can be easily modulated. For comparison purposes, the counterparts, that is, pure silica SBA‐1 MSNs (CS‐0) and those with either carboxylic acid or amino functional groups (denoted as CS‐10 and NS‐10, respectively) were also prepared to evaluate their dye‐adsorption behaviors. As revealed by the zeta‐potential measurements, the electrostatic interaction between the adsorbent surface and the dye molecule plays an important role in the adsorption mechanism. Adsorbent CNS‐10‐10 can be easily regenerated and reused, and maintains its adsorption efficiency up to 80 % after four cycles.
Screening and identification of multiple constituents and their metabolites of Zhi‐zi‐chi decoction in rat urine and bile by ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry
Authors: Feng Wei , Dong Qiuju , Liu Minyan , Li Si , Liu Ting , Wang Xinguo , Niu Liying 
Published: March 2017

AbstractZhi‐zi‐chi decoction (ZZCD) is a classical formula widely used in Chinese clinical application. In the present study, a novel and efficient strategy has been developed for screening and identification of multiple constituents and their metabolites of ZZCD using ultra‐high‐performance liquid chromatography combined with triple time‐of‐flight mass spectrometry. The novel approach of an online data acquisition method dependent on multiple mass defect filter and dynamic background subtraction is combined with multiple data processing techniques. First, a total of 109 potential bioactive compounds were detected in ZZCD. Based on the same instrumental conditions, 100 compounds were found in rat biofluids after oral administration of ZZCD, including 61 original compounds of ZZCD as well as 39 metabolites. Conjugations with sulfate, glucuronate and amino acids were found as the predominant metabolic reaction of ZZCD. As more xenobiotics were detected in urine than those in bile were, it demonstrated that multiple components of ZZCD have undergone comprehensive renal excretion. This study reported the urinary and biliary excretion in rats after oral administration of ZZCD for the first time. The present study expands our knowledge about the constituents and metabolism of ZZCD, which could be very useful for further pharmacological and clinical studies of ZZCD.
Data‐driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration
Authors: Binney Richard J. , Pankov Aleksandr , Marx Gabriel , He Xuanzie , McKenna Faye , Staffaroni Adam M. , Kornak John , Attygalle Suneth , Boxer Adam L. , Schuff Norbert , Gorno‐Tempini Maria‐Luisa , Weiner Michael W. , Kramer Joel H. , Miller Bruce L. , Rosen Howard J. 
Published: March 2017

AbstractIntroductionLongitudinal imaging of neurodegenerative disorders is a potentially powerful biomarker for use in clinical trials. In Alzheimer's disease, studies have demonstrated that empirically derived regions of interest (ROIs) can provide more reliable measurement of disease progression compared with anatomically defined ROIs.MethodsWe set out to derive ROIs with optimal effect size for quantifying longitudinal change in a hypothetical clinical trial by comparing atrophy rates in 44 patients with behavioral variant of frontotemporal dementia (bvFTD), 30 with the semantic variant primary progressive aphasia (svPPA), and 26 with the nonfluent variant PPA (nfvPPA) to atrophy in 97 cognitively healthy controls.ResultsThe regions identified for each variant were generally what would be expected from prior studies of frontotemporal lobar degeneration (FTLD). Sample size estimates for detecting a 40% reduction in annual rate of ROI atrophy varied substantially across groups, being 103 per arm in bvFTD, 31 in nfvPPA, and 10 in svPPA, but in all groups were less than those estimated for a priori ROIs and clinical measures. The variability in location of peak regions of atrophy across individuals was highest in bvFTD and lowest in svPPA, likely relating to the differences in effect size.ConclusionsThese findings suggest that, while cross‐validated maps of change can improve sensitivity to change in FTLD compared with a priori regions, the reliability of these maps differs considerably across syndromes. Future studies can utilize these maps to design clinical trials, and should try to identify factors accounting for the variability in patterns of atrophy across individuals, particularly those with bvFTD.
Web 2.0 applications for engineering education: Faculty members’ perception, barriers, and solutions
Authors: Zarei Ataollah , Mohd‐Yusof Khairiyah , Daud Mohd Fadzil , Azizi Nematollah 
Published: March 2017

ABSTRACTDespite increasing the number of engineering departments and students in Iran, the quality of education is less than satisfactory. Regarding the huge potential of Web 2.0 applications, which is also known as Web 2.0 tools, Web 2.0 services, or social media, for improving the quality of teaching and learning, this study was undertaken to investigate the perception of the faculty members toward using these technologies for teaching and learning engineering, the ways they use these tools for educational aims, and the factors that influence. The systematic design of grounded theory method was followed to achieve the research objectives. In addition, the required data was collected through interview and questionnaire and NVivo 8 software was used to facilitate data analysis process. The results show that the faculty members use some of these applications occasionally for the sole purpose of obtaining information. The traditional teaching method, which is influenced by the instructors’ traditional mindset, traditional curricula, and organizational disregard for the quality of teaching, are the most salient factors. Also, instructors’ emotional barriers and limited access to these tools in Iran are subsidiary factors influencing the failure to use these tools for teaching engineering. © 2017 Wiley Periodicals, Inc. Comput Appl Eng Educ 25:449–457, 2017; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21812
Bilingual subtitles for second‐language acquisition and application to engineering education as learning pills
Authors: García Boni 
Published: March 2017

ABSTRACTThis paper introduces the concept of bilingual subtitles, a kind of captioning in which a pair of subtitles (in the mother tongue, L1, and second language, L2) is shown at the same time on the screen. The aim of dual subtitles is to help the final user in different learning processes, due to the fact that several capacities (listening, reading, and matching) are exercised at the same time by the learner while watching dual‐captioned media. The contribution of this paper is threefold. First, it presents DualSub, an open source desktop tool aimed to create bilingual subtitles. Second, a descriptive study was designed and executed to evaluate the extent to which bilingual subtitles are perceived by final users in the incidental vocabulary knowledge of a second language. Third, an experimental case study in which dual subtitles were used in the engineering education arena was carried out. The results of these surveys confirm that bilingual subtitles are perceived as useful in the different dimensions of the incidental vocabulary learning process (form, meaning, use) and are also helpful when applied to the educational domain (deliberate learning). © 2017 Wiley Periodicals, Inc. Comput Appl Eng Educ 25:468–479, 2017; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21814
GOLPH3 induces epithelial–mesenchymal transition via Wnt/β‐catenin signaling pathway in epithelial ovarian cancer
Authors: Sun Jing , Yang Xiaoming , Zhang Ru , Liu Suqing , Gan Xupei , Xi Xiaowei , Zhang Zhenbo , Feng Youji , Sun Yunyan 
Published: March 2017

AbstractGolgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain poorly understood. Here, we found that GOLPH3 was overexpressed in EOC tissues and cell lines. This overexpression promoted the migration and invasion of EOC cells. Moreover, GOLPH3 upregulated the expression of epithelial–mesenchymal transition (EMT) markers, such as N‐cadherin and Snail, and the Wnt/β‐catenin‐related genes cyclin‐D1 and c‐Myc, which were restored via silencing of GOLPH3 expression. Furthermore, the inhibitor and activator of the Wnt/β‐catenin pathway, XAV939 and LiCl, enhanced or decreased, respectively, the effect of GOLPH3 on EMT, which further confirmed that GOLPH3 promoted EMT progression via activation of Wnt/β‐catenin signaling. In addition, we found that EDD, the human hyperplastic discs gene, was consistent with GOLPH3 expression and also promoted the EMT process and activated Wnt/β‐catenin signaling. These findings demonstrate that EDD might be a downstream factor of GOLPH3. Taken together, our findings demonstrate the existence of a GOLPH3–Wnt/β‐catenin–EMT axis in EOC and provide a new therapeutic target to treat EOC.
The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
Authors: Park Eun‐Ran , Kim Sang‐Bum , Lee Jee‐San , Kim Yang‐Hyun , Lee Dong‐Hyoung , Cho Eung‐Ho , Park Sun‐Hoo , Han Chul Ju , Kim Bu‐Yeo , Choi Dong Wook , Yoo Young Do , Yu Ami , Lee Jae Won , Jang Ja June , Park Young Nyun , Suh Kyung‐Suk , Lee Kee‐Ho 
Published: March 2017

AbstractAlterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real‐time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1‐fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan–Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence‐free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the α‐fetoprotein (AFP) level. The patient subgroup with higher AFP levels (≥20 ng/mL) exhibited significant differences in 5‐year overall (18.5% vs. 67.9%) and recurrence‐free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (<20 ng/mL). Multivariate analysis defined UQCRH as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH overexpression is correlated with poor outcomes of HCC patients. Furthermore, in patients grouped as high risk based on elevated AFP, lack of UQCRH overexpression could be a useful indicator for clinical treatment.