bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Prediction Model to Estimate the Risk of Walking Limitations in Patients with Total Knee Arthroplasty
Authors: Pua Yong-Hao , Seah Felicia Jie-Ting , Clark Ross Allan , Poon Cheryl Lian-Li , Tan John Wei-Ming , Chong Hwei-Chi 
Published: December 2015

Objective.Early and accurate risk prediction of walking limitations after total knee arthroplasty (TKA) is important for clinical and economic reasons. However, to our knowledge, no studies have systematically integrated multiple predictors into a single, clinically practical model. Our study aimed to develop a prediction model to estimate the risk of post-TKA walking limitations.Methods.We performed a prospective cohort study of 1096 patients who underwent elective, primary TKA between July 2013 and September 2014. Candidate predictors included patient demographics, surgical factors, and pre- and early (1-mo) post-TKA functional measures. The outcome of interest was self-reported walking limitations at 6 months of post-TKA. We used multivariable proportional odds regression with bootstrap internal validation to develop the model.Results.In all, 12% of patients reported walking limitations (maximum walk time ≤ 15 min) at 6 months postsurgery. The main predictors of increasing levels of walking limitations were preoperative walking limitations (overall p < 0.001), higher levels of body mass index [interquartile range (IQR)-OR 1.3, 95% CI 1.2–1.5], lower values of 1-month post-TKA gait speed (IQR-OR 1.9, 95% CI 1.3–2.6), the presence of contralateral knee pain (OR 1.9, 95% CI 1.2–3.0), and the use of a quadstick preoperatively (OR 3.5, 95% CI 1.7–7.3). The prediction model had an optimism-corrected concordance index of 0.71.Conclusion.A small but sizable proportion of patients with TKA had persistent mobility limitations. Our prediction model may help to risk-stratify patients, and external validation is required before the model can be used in clinical practice.
L’institutionnalisation de la recherche comptable et de l’AFC en France : un processus fragile
Authors: Bessire Dominique , Levant Yves , Nikitin Marc 
Published: December 2015

Cet article tente d’éclairer le processus d’institutionnalisation de la recherche comptable et de l’AFC en France, en mettant au jour l’histoire de l’Association Francophone de Comptabilité (AFC). Nous tentons de comprendre comment s’est progressivement constitué un embryon de communauté scientifique, comment cette communauté s’est développée et structurée, mais aussi quelles sont les menaces qui pèsent sur elle aujourd’hui, alors que la reconnaissance de la part de l’ensemble de la communauté scientifique en sciences sociales est encore loin d’être acquise. Nous empruntons, pour ce faire, des éléments tirés des théories néo-institutionnelles. La méthode employée consiste en une analyse critique des sources disponibles : témoignages d’anciens dirigeants, actes des congrès, lettres de l’AFC, archives diverses.
“Je vais et je viens entre terrains” Réflexions sur le terrain dans la théorisation sociolinguistique
Authors: Gasquet-Cyrus Médéric 
Published: December 2015

Souvent déconsidérée pour sa supposée faiblesse théorique, la sociolinguistique est plus qu’une linguistique de terrain centrée sur la collecte de données « authentiques ». Ce texte défend l’idée que l’empirisme fondamental de la sociolinguistique lui permet de générer des constructions théoriques issues du terrain lui-même. Chaque terrain, inscrit dans des réalités locales et historiques spécifiques, nécessite un investissement et une implication du chercheur lequel rend compte, de son point de vue, des pratiques langagières situées des locuteurs. La fréquentation de différents terrains permet du recul par rapport aux théories homogénéisantes qui simplifient des situations a priori similaires pourtant fort éloignées. C’est au cœur même du terrain que se façonnent les objets et les théories destinées à les appréhender, faisant de la sociolinguistique une autre façon de faire de la linguistique.
L’ethnographie comme méthode d’enquête sociolinguistique : « faire preuve » à partir d’un cas singulier ?
Authors: Hambye Philippe 
Published: December 2015

Cet article interroge la façon dont une enquête ethnographique (en sociolinguistique) peut contribuer au travail théorique à visée généralisante malgré la singularité assumée de ses données d’observation. Partant de la réflexion épistémologique de Passeron (2006) sur la singularité irréductible des faits sociaux qui envisage les sciences de l’homme et de la société comme des « sciences historiques », l’auteur illustre la façon dont sa recherche ethnographique auprès d’adolescents en milieu scolaire permet de monter en généralité et peut être mobilisée pour discuter de la pertinence d’un concept – celui de crossing (Rampton 2005) – régulièrement utilisé dans les travaux sur les « parlers jeunes ».
De l’« anomie » contemporaine : ordre social et nouvelle morale sexuelle
Authors: Bergami G. Barbosa Pablo 
Published: December 2015

Le présent article explore la notion d’une « anomie postmoderne » comme caractéristique des sociétés contemporaines. Cette notion se manifeste dans la théorie psychanalytique de la culture à travers l’idée de la « disparition du grand Autre », qui fait ici l’objet d’une critique focalisée sur la « morale sexuelle contemporaine ». L’auteur met en évidence que cette dernière se caractérise effectivement par une certaine libéralisation des mœurs, mais qu’elle n’engendre pas un dérèglement de la vie sexuelle. Une morale sexuelle basée sur des prescriptions positives (en opposition aux interdits du passé) garantit toujours un ordonnancement de la psychosexualité. Cette nouvelle morale sexuelle témoigne également de la pérennité des concepts freudiens fondamentaux pour penser les racines pulsionnelles de l’organisation sociale.
Les désordres de l’organisation
Authors: Potier Elwis 
Published: December 2015

Le psychosociologue intervenant dans les structures du champ médico-social peut observer les effets d’une forme de « surorganisation » qui affecte les institutions comme les sujets qui y vivent et les font vivre. Après avoir relever certains signes cliniques qui permettent d’en comprendre les manifestations dans l’intervention, la description d’une séance d’analyse de pratiques de professionnels exerçant dans un dispositif d’AEMO renforcée entraîne une interprétation des réactions groupales suscitées par l’évocation de l’abus d’un enfant à partir de la notion de porte-parole de Piera Aulagnier. L’idéal du nous porteur des fonctions symboliques du collectif paraît alors reposer sur l’ambivalence vis-à-vis de l’organisation.
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF
Authors: Kang SunAh , Keener Amanda B. , Jones Shannon Z. , Benschop Robert J. , Caro-Maldonado Alfredo , Rathmell Jeffrey C. , Clarke Stephen H. , Matsushima Glenn K. , Whitmire Jason K. , Vilen Barbara J. 
Published: December 2015

Abstract
Memory B cell responses are vital for protection against infections but must also be regulated to prevent autoimmunity. Cognate T cell help, somatic hypermutation, and affinity maturation within germinal centers (GCs) are required for high-affinity memory B cell formation; however, the signals that commit GC B cells to the memory pool remain unclear. In this study, we identify a role for IgG-immune complexes (ICs), FcγRs, and BAFF during the formation of memory B cells in mice. We found that early secretion of IgG in response to immunization with a T-dependent Ag leads to IC–FcγR interactions that induce dendritic cells to secrete BAFF, which acts at or upstream of Bcl-6 in activated B cells. Loss of CD16, hematopoietic cell–derived BAFF, or blocking IC:FcγR regions in vivo diminished the expression of Bcl-6, the frequency of GC and memory B cells, and secondary Ab responses. BAFF also contributed to the maintenance and/or expansion of the follicular helper T cell population, although it was dispensable for their formation. Thus, early Ab responses contribute to the optimal formation of B cell memory through IgG-ICs and BAFF. Our work defines a new role for FcγRs in GC and memory B cell responses.
Host Foxp3+CD4+ Regulatory T Cells Act as a Negative Regulator of Dendritic Cells in the Peritransplantation Period
Authors: Inoue Takayuki , Ikegame Kazuhiro , Kaida Katsuji , Okada Masaya , Yoshihara Satoshi , Tamaki Hiroya , Fujimori Yoshihiro , Soma Toshihiro , Ogawa Hiroyasu 
Published: December 2015

Abstract
Host Foxp3+CD4+ regulatory T cells (Tregs) have been shown to suppress graft-versus-host disease (GVHD) in experimental bone marrow transplantation (BMT) models; however, the detailed mechanism is unknown. To address this issue, we established a murine MHC-haploidentical BMT model (BDF1 (H-2b/d) → B6C3F1 (H-2b/k)), in which transplantation following conditioning with high-dose (13 Gy) or low-dose (5 Gy) total body irradiation corresponds to myeloablative stem cell transplantation (MAST) or reduced-intensity stem cell transplantation (RIST) BMT. All MAST recipients died of GVHD within 70 d, whereas RIST recipients developed almost no GVHD and survived for at least 3 mo. In this BMT model, we investigated the kinetics of immune cells in the mesenteric lymph nodes because GVHD was most prominent in the intestines. Host Tregs that survived after total body irradiation could proliferate transiently by day 4. Comparing the kinetics of immune cells among MAST, RIST, and anti-CD25 mAb-treated RIST, we found that the transiently surviving host Tregs were fully functional, closely contacted with host dendritic cells (DCs), and significantly restrained the maturation (CD80 and CD86 expression) of DCs in a dose-dependent manner. There was a positive correlation between the ratio of DCs to host Tregs and the extent of maturation of DCs. Host Tregs suppressed alloresponse mainly by contact inhibition. Host Tregs are already active in lymph nodes before transplantation and restrain the maturation of host DCs, thereby dampening the ability of DCs to activate allogeneic donor T cells and consequently reducing the magnitude of graft-versus-host reaction. Thus, host Tregs are negative regulators of host DCs that act in the peritransplantation period.
Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells
Authors: Fukui Ryutaro , Kanno Atsuo , Miyake Kensuke 
Published: December 2015

Abstract
TLR7 recognizes pathogen-derived and self-derived RNA, and thus a regulatory system for control of the TLR7 response is required to avoid excessive activation. Unc93 homolog B1 (Unc93B1) is a regulator of TLR7 that controls the TLR7 response by transporting TLR7 from the endoplasmic reticulum to endolysosomes. We have previously shown that a D34A mutation in Unc93B1 induces hyperactivation of TLR7, and that Unc93b1D34A/D34A mice (D34A mice) have systemic inflammation spontaneously. In this study, we examined the roles of inflammatory cytokines such as IFN-γ, IL-17A, and type I IFNs to understand the mechanism underlying the phenotype in D34A mice. mRNAs for IFN-γ and IL-I7A in CD4+ T cells increased, but inflammatory phenotype manifesting as thrombocytopenia and splenomegaly was still observed in Ifng−/− or Il17a−/− D34A mice. In contrast to T cell–derived cytokines, Ifnar1−/− D34A mice showed an ameliorated phenotype with lower expression of TLR7 in B cells and conventional dendritic cells (cDCs). The amount of TLR7 decreased in B cells from Ifnar1−/− D34A mice, but the percentage of TLR7+ cells decreased among CD8α− cDCs. In conclusion, type I IFNs maintain expression of TLR7 in B cells and cDCs in different ways; total amount of TLR7 is kept in B cells and TLR7+ population is retained among cDCs. Our results suggested that these TLR7-expressing cells are activated initially and influence TLR7-dependent systemic inflammation.
GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo
Authors: Webb Louise M. C. , Datta Preeta , Bell Sarah E. , Kitamura Daisuke , Turner Martin , Butcher Geoffrey W. 
Published: December 2015

Abstract
An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell–mediated diseases.
The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions
Authors: Dimeloe Sarah , Mehling Matthias , Frick Corina , Loeliger Jordan , Bantug Glenn R. , Sauder Ursula , Fischer Marco , Belle Réka , Develioglu Leyla , Tay Savaş , Langenkamp Anja , Hess Christoph 
Published: December 2015

Abstract
Effector memory (EM) CD4+ T cells recirculate between normoxic blood and hypoxic tissues to screen for cognate Ag. How mitochondria of these cells, shuttling between normoxia and hypoxia, maintain bioenergetic efficiency and stably uphold antiapoptotic features is unknown. In this study, we found that human EM CD4+ T cells had greater spare respiratory capacity (SRC) than did naive counterparts, which was immediately accessed under hypoxia. Consequently, hypoxic EM cells maintained ATP levels, survived and migrated better than did hypoxic naive cells, and hypoxia did not impair their capacity to produce IFN-γ. EM CD4+ T cells also had more abundant cytosolic GAPDH and increased glycolytic reserve. In contrast to SRC, glycolytic reserve was not tapped under hypoxic conditions, and, under hypoxia, glucose metabolism contributed similarly to ATP production in naive and EM cells. However, both under normoxic and hypoxic conditions, glucose was critical for EM CD4+ T cell survival. Mechanistically, in the absence of glycolysis, mitochondrial membrane potential (ΔΨm) of EM cells declined and intrinsic apoptosis was triggered. Restoring pyruvate levels, the end product of glycolysis, preserved ΔΨm and prevented apoptosis. Furthermore, reconstitution of reactive oxygen species (ROS), whose production depends on ΔΨm, also rescued viability, whereas scavenging mitochondrial ROS exacerbated apoptosis. Rapid access of SRC in hypoxia, linked with built-in, oxygen-resistant glycolytic reserve that functionally insulates ΔΨm and mitochondrial ROS production from oxygen tension changes, provides an immune-metabolic basis supporting survival, migration, and function of EM CD4+ T cells in normoxic and hypoxic conditions.
De koers van de Hoge Raad: (on)voorspelbaar?
Authors: Klaassen C.J.M. 
Published: December 2015

De koers van de Hoge Raad: (on)voorspelbaar?
De auteur gaat in op de taak van de Hoge Raad om de rechtseenheid en de rechtsontwikkeling te bevorderen. Aan de hand van een aantal arresten op het terrein van het aansprakelijkheidsrecht stelt zij de vraag of de koers van de Hoge Raad wel voldoende voorspelbaar is en op welke wijze de Hoge Raad de voorspelbaarheid van zijn beslissingen kan verbeteren.
De bijdrage van de civiele cassatieadvocatuur aan de rechterlijke rechtsvorming
Authors: Vranken J.B.M. 
Published: December 2015

De bijdrage van de civiele cassatieadvocatuur aan de rechterlijke rechtsvorming
De auteur behandelt de bijdrage van de cassatieadvocatuur aan de rechtsontwikkeling door de Hoge Raad in civiele zaken aan de hand van twee stellingen. De eerste stelling luidt dat de cassatieadvocatuur mede verantwoordelijk is voor de toegang tot de cassatierechtspraak, dat wil zeggen dat de cassatieadvocatuur ervoor dient te zorgen dat bepaalde zaken de Hoge Raad daadwerkelijk bereiken. De tweede stelling is dat versterking van de rechtsvormende taak van de Hoge Raad soms een bredere kennis van de context van de zaak vereist.
De objectivering van de bevoordelingsbedoeling in het erfrecht
Authors: Brans F.W. , Raaijmaakers Ph.A.J. 
Published: December 2015

De objectivering van de bevoordelingsbedoeling in het erfrecht
Aan de hand van twee uitspraken uit eigen praktijk wordt onderzocht welke omstandigheden een rol kunnen spelen bij de beoordeling of sprake is van een gift, hoe en waarop deze wordt gewaardeerd, of de legitimaire massa daarmee wordt vermeerderd en op welk wettelijk breukdeel daarvan de legitimaris aanspraak kan maken. Conclusie is dat wordt gekeken naar omstandigheden van vóór of tijdens het moment van de gestelde gift (‘objectief’). Omstandigheden van latere datum blijven in beginsel buiten beschouwing, ook als achteraf daaruit een wil of intentie tot bevoordelen kan worden herleid (‘subjectief’).
Advancing the sexual and reproductive health and human rights of women living with HIV: a review of UN, regional and national human rights norms and standards
Authors: Khosla Rajat , Van Belle Nuna , Temmerman Marleen 
Published: December 2015

IntroductionThe right to sexual and reproductive health (SRH) is an essential part of the right to health and is dependent upon substantive equality, including freedom from multiple and intersecting forms of discrimination that result in exclusion in both law and practice. Nonetheless, general and specific SRH needs of women living with HIV are often not adequately addressed. For example, services that women living with HIV need may not be available or may have multiple barriers, in particular stigma and discrimination. This study was conducted to review United Nations Human Rights Council, Treaty Monitoring Bodies and Special Rapporteur reports and regional and national mechanisms regarding SRH issues of women living with HIV. The objective is to assess areas of progress, as well as gaps, in relation to health and human rights considerations in the work of these normative bodies on health and human rights.MethodsThe review was done using keywords of international, regional and national jurisprudence on findings covering the 2000 to 2014 period for documents in English; searches for the Inter‐American Commission on Human Rights and national judgments were also conducted in Spanish. Jurisprudence of UN Treaty Monitoring Bodies, regional mechanisms and national bodies was considered in this regard.Results and discussionIn total, 236 findings were identified using the search strategy, and of these 129 were selected for review based on the inclusion criteria. The results highlight that while jurisprudence from international, regional and national bodies reflects consideration of some health and human rights issues related to women living with HIV and SRH, the approach of these bodies has been largely ad hoc and lacks a systematic integration of human rights concerns of women living with HIV in relation to SRH. Most findings relate to non‐discrimination, accessibility, informed decision‐making and accountability. There are critical gaps on normative standards regarding the human rights of women living with HIV in relation to SRH.ConclusionsA systematic approach to health and human rights considerations related to women living with HIV and SRH by international, regional and national bodies is needed to advance the agenda and ensure that policies and programmes related to SRH systematically take into account the health and human rights of women living with HIV.
Study on ozone treatment of soil for agricultural application of surface dielectric barrier discharge
Authors: Nagatomo Takuya , Abiru Tomoya , Mitsugi Fumiaki , Ebihara Kenji , Nagahama Kazuhiro 
Published: December 2015

Abstract
Recently, application of plasma technologies to the agricultural field has attracted much interest because residual pesticides and excessive nitrogen oxides contained in plants, soil, and groundwater have become a serious issue worldwide. Since almost all of the atmospheric discharge plasma generates ozone, the effects of ozone are among the key factors for their agricultural applications. We have proposed the use of ozone generated using surface barrier discharge plasma for soil disinfection or sterilization. In this work, the ozone consumption coefficient and diffusion coefficient in soil were measured by the ultraviolet absorption method. The pH(H2O) and amount of nitrogen nutrient in soil after ozone diffusion treatment were studied and plant growth was observed simultaneously. The effect of ozone treatment on the amount of DNA in soil was also investigated and compared with that determined from the obtained ozone consumption coefficient.
Immobilization of Ag-deposited Au nanoprisms by thiol-coupling and oil-coating methods
Authors: Noda Yuta , Hayakawa Tomokatsu 
Published: December 2015

Abstract
We have demonstrated the immobilization of Ag-deposited Au (Au@Ag) nanoprisms on glass substrates by two different methods: self-assembly on a thiol-modified glass (thiol-coupling method) and evaporation of the Au@Ag nanoprism colloidal solution in silicone oil (oil-coating method). In the thiol-coupling method, the Au@Ag nanoprisms were well dispersed and accumulated on the substrates as single or stacked layers. On the other hand, the oil-coating method allowed Au@Ag nanoprisms to accumulate as multilayers without excessive agglomeration. The multilayers of Au@Ag nanoprisms were subjected to surface-enhanced Raman scattering (SERS), and a very low concentration (2.1 × 10−5 M) of rhodamine 6G molecules was sensitively detected.
Upright or inverted, entire or exploded: right-hemispheric superiority in face recognition withstands multiple spatial manipulations
Authors: Prete Giulia , Marzoli Daniele , Tommasi Luca 
Published: December 2015

Background.The ability to identify faces has been interpreted as a cerebral specialization based on the evolutionary importance of these social stimuli, and a number of studies have shown that this function is mainly lateralized in the right hemisphere. The aim of this study was to assess the right-hemispheric specialization in face recognition in unfamiliar circumstances.Methods.Using a divided visual field paradigm, we investigated hemispheric asymmetries in the matching of two subsequent faces, using two types of transformation hindering identity recognition, namely upside-down rotation and spatial “explosion” (female and male faces were fractured into parts so that their mutual spatial relations were left intact), as well as their combination.Results.We confirmed the right-hemispheric superiority in face processing. Moreover, we found a decrease of the identity recognition for more extreme “levels of explosion” and for faces presented upside-down (either as sample or target stimuli) than for faces presented upright, as well as an advantage in the matching of female compared to male faces.Discussion.We conclude that the right-hemispheric superiority for face processing is not an epiphenomenon of our expertise, because we are not often exposed to inverted and “exploded” faces, but rather a robust hemispheric lateralization. We speculate that these results could be attributable to the prevalence of right-handedness in humans and/or to early biases in social interactions.