bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical expression of cereblon and MUM1 as potential predictive markers of response to lenalidomide in extranodal marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue (MALT lymphoma)
Authors: Kiesewetter Barbara , Simonitsch‐Klupp Ingrid , Kornauth Christoph , Dolak Werner , Lukas Julius , Mayerhoefer Marius E. , Raderer Markus 
Published: August 2017

AbstractLenalidomide is an active agent for the treatment of MALT lymphoma. Recently, high expression levels of cereblon (CRBN) and MUM1 have been associated with better response rates in multiple myeloma treated with lenalidomide. However, there are no data on CRBN and MUM1 expression in MALT lymphoma. In the current study, we have systematically investigated a potential correlation of CRBN/MUM1 immunohistochemical expression and response to lenalidomide‐based therapy in a series of 46 patients with MALT lymphoma treated at the Medical University Vienna 2009 to 2014. In total, 28% (13/46) of biopsy specimens derived from gastric tissues, while 72% (33/46) originated from extragastric MALT lymphoma. In terms of CRBN, 54% showed high expression (CRBN+, ≥50% positive cells); the remaining 46% were classified as low expression (CRBN−). In contrast to other reports, there was a non‐significant trend towards worse response rates in CRBN+ (68% versus 86%, P = 0.161). Relapse rates (P = 0.592) and PFS (P = 0.306) did not differ between CRBN+/CRBN−, but all 3 patients progressing on lenalidomide were CRBN+ and both patients completely lacking CRBN expression responded to treatment. Concerning MUM1, 62% were MUM1‐negative (MUM1−) and 38% positive (MUM1+). There was no difference in response to lenalidomide by MUM1‐status (MUM1+ 71% versus MUM1− 79%, P = 0.546) and also relapse rates (P = 0.828) and PFS (P = 0.681) did not differ. Interestingly, a subgroup analysis of gastric lymphoma revealed a significantly better PFS for CRBN− and MUM1− patients, respectively (both P < 0.05). To conclude, there was no significant difference in response to lenalidomide between patients with low or high expression of CRBN/MUM1 in a general population of MALT lymphoma, and immunohistochemical CRBN/MUM1 assessment cannot be recommended in the clinical routine.
Asymmetric Transfer Hydrogenation of Ketones Using New Iron(II) (P‐NH‐N‐P′) Catalysts: Changing the Steric and Electronic Properties at Phosphorus P′
Authors: Smith Samantha A. M. , Prokopchuk Demyan E. , Morris Robert H. 
Published: August 2017

AbstractThe asymmetric transfer hydrogenation (ATH) of ketones is an efficient method for producing enantio‐enriched alcohols which are used as intermediates in a variety of industrial processes. Here we report the synthesis of new iron ATH precatalysts (S,S)‐[FeBr(CO)(Ph2PCH2CH2NHCHPhCHPhNC=CHCH2PR′2)][BPh4] (R′=Et, and ortho‐tolyl (o‐Tol)) where one of the phosphine groups is modified with small alkyl and large aryl substituents to probe the effect of this change on the activity and selectivity of the catalytic system. A simple reversible equilibrium kinetic model is used to obtain the initial TOF and the inherent enantioselectivity S=kR/kS of these catalysts along with those for the previously reported catalysts with R′=Ph and Cy for the ATH of acetophenone. With an increase in the size of the PR′2 group, the TOF goes through a maximum at PPh2 while the S value goes through a maximum of 510 at R′=Cy. The complex with R′=o‐Tol starts with a high S value of 200 but is rapidly changed to a second catalyst with an S value of 28. For the reduction of acetophenone to (R)‐1‐phenylethanol, turnover numbers of up to 5200 and ee up to 98 % were achieved. The chemotherapeutic pharmaceutical precursor (R)‐(3′,5′‐bis(trifluoromethyl))‐1‐phenylethanol is synthesized in up to 95 % ee. Several other alcohols can be prepared in greater than 90 % ee by choosing the precatalyst with the correctly matched steric properties. A hydride complex derived from the catalyst with R′=Cy is characterized by NMR spectroscopy. It is proposed that low concentration trans‐hydride carbonyl complexes with the FeH parallel to the NH of the ligand are the active catalysts in all of these systems.
Mononuclear cell collection for extracorporeal photopheresis: Concentrate characteristics for off‐line UV‐A irradiation procedure
Authors: Piccirillo Nicola , Putzulu Rossana , Massini Giuseppina , Fiore Assunta Gessica , Chiusolo Patrizia , Sica Simona , Zini Gina 
Published: August 2017

Background and objectiveExtracorporeal photopheresis (ECP) is the most represented cell therapy for treatment of cutaneous T‐cell lymphoma, graft‐versus host disease and organ rejection. We analyzed our experience in ECP using 2 cell separators (Cobe Spectra and Spectra Optia) focusing on leukapheretic product characteristics, UV‐A irradiation procedure and entire ECP process.Materials and methodsWe collected data of patients undergoing ECP between January 2012 and February 2015 in order to evaluate collection procedures performed using Cobe Spectra and Spectra Optia, mononuclear cell product, UV‐A photoirradiation procedure by Pit System.ResultsWe performed 484 ECP procedures in 27 patients. Cobe‐derived mononuclear cell products were characterized by higher cell yields while Optia‐derived mononuclear cell products were characterized by smaller volume, comparable mononuclear cell content but lower erythrocytes, granulocytes, and platelets contamination.ConclusionOur study confirms good results for both cell separators. Blood volume processed being equal, Cobe collects a number of total nucleated cells significantly higher than Optia. Optia, collecting only target cells without significant erythrocytes, granulocytes and platelets contamination, is able to collect a leukapheretic product particularly suitable for ECP.
Suitability of pyrolusite as additive to activated coke for low‐temperature NO removal
Authors: Yang Lin , Jiang Wenju , Yao Lu , Jiang Xia , Li Jianjun 
Published: August 2017

AbstractBACKGROUNDPyrolusite was used as additive to prepare coal‐based activated coke (AC) for low‐temperature NO removal. The pyrolusite modified AC was prepared by a blending method, and the denitrification performance was evaluated in a lab‐scale simulated fixed‐bed reactor.RESULTSThe blending of pyrolusite promoted the specific surface area and pore structure of AC, even though the MnO2 and Fe2O3 showed inhibitory effects when blended separately. Both the basic and acid sites of AC‐Mn(x) increased owing to the participation of the blended MnO2 during the activation, while the blending of Fe2O3 showed an inhibited effect. AC‐P10 showed the highest NO removal efficiency at 74.2%, which was 32.8%, 27.0% and 24.2% higher than that of AC, AC‐Mn4 and AC‐Fe6. The operating temperature adaptability and stability of catalysis activity of AC‐P10 are good. Manganese is the main catalyst of AC‐P(x), and Fe is an accelerant to stimulate the catalytic activity of Mn. The extremely high NO removal activity of AC‐P(x) was due to the synergistic effect of surface functional groups and metals, but the catalysis of metals played a more important role.CONCLUSIONPyrolusite is suitable to prepare the AC‐based denitrification catalyst (AC‐P(x)) for SCR NO removal because the Mn and Fe contained in the pyrolusite showed a synergistic effect. © 2017 Society of Chemical Industry
Immune profiles vary seasonally, but are not significantly related to migration distance or natal dispersal, in a migratory songbird
Authors: Kelly Tosha R. , MacGillivray Heather L. , Hobson Keith A. , MacDougall‐Shackleton Scott A. , MacDougall‐Shackleton Elizabeth A. 
Published: August 2017

AbstractA central tenet of ecoimmunology is that an organism's environment shapes its optimal investment in immunity. For example, the benefits of acquired (relatively pathogen specific) versus innate (nonspecific) immune defenses are thought to vary with the risk of encountering familiar versus unfamiliar pathogens. Because pathogen communities vary geographically, individuals that travel farther during seasonal migration or natal dispersal are predicted to have higher exposure to novel pathogens, and lower exposure to familiar pathogens, potentially favoring investment in innate immunity. During the breeding season, migratory animals’ exposure to familiar pathogens should increase, potentially favoring investment in acquired immunity. We hypothesized that song sparrows Melospiza melodia adjust their constitutive immune profiles in response to risk of encountering novel versus familiar pathogens. We predicted that individuals migrating longer distances (inferred from stable hydrogen isotope analysis of claws) and less philopatric individuals (inferred from microsatellite assignment testing) would rely more heavily on acquired than innate defenses. We also predicted that reliance on acquired defenses would increase throughout the early breeding season. Consistent with trade‐offs between acquired and innate defenses, levels of immunoglobulin Y (acquired) varied negatively with macrophage phagocytosis activity (innate). Levels of acquired relative to innate immunity did not vary significantly with migration distance or philopatry, but increased throughout the early breeding season. Macrophage phagocytosis was not significantly repeatable between years. Song sparrows appear to shift from innate defenses immediately after migration to acquired defenses with increasing time at the breeding grounds. These patterns highlight the plasticity of constitutive immune defenses in migratory animals.
Pseudoinheritance and Chronicity in Social Exclusion: Stressful Life Events in Childhood and Precocious Adulthood Among Trash Pickers in León (Nicaragua)
Authors: Vázquez José Juan 
Published: August 2017

AbstractThis study analyses the stressful life events experienced in childhood and adolescence and the onset of precocious adulthood among individuals who earn their livelihood in the dump (n = 99) in León (Nicaragua). The results show that the trash pickers of León suffered from many stressful life events during their childhood and adolescence, which were extremely serious and occurred from very early ages. Furthermore, these people began to engage in adult activities at a very early age. Both factors may have a significant impact on the chronicity of the trash pickers' social exclusion. Copyright © 2017 John Wiley & Sons, Ltd.
Public Sector Corruption and Trust in the Private Sector
Authors: Gillanders Robert , Neselevska Olga 
Published: August 2017

AbstractUsing Afrobarometer data, we show that experiencing bribery in the course of one's interactions with the public sector lowers one's trust in big private corporations, small businesses and local traders. As trust in market institutions is vital to the efficient functioning of an economy, our findings point to a previously unknown and potentially substantial cost of corruption. This relationship is evident even when we control for perceptions of corruption. Our findings are not driven by corruption lowering interpersonal trust. Having to pay a bribe for household services is the corrupt interaction most strongly associated with the decline in private sector trust. Copyright © 2017 John Wiley & Sons, Ltd.
Characterization of phenolic compounds in green and red oak‐leaf lettuce cultivars by UHPLC‐DAD‐ESI‐QToF/MS using MSE scan mode
Authors: Viacava Gabriela E. , Roura Sara I. , Berrueta Luis A. , Iriondo Carmen , Gallo Blanca , Alonso‐Salces Rosa M. 
Published: August 2017

AbstractLettuce (Lactuca sativa) is one of the most popular leafy vegetables in the world and constitutes a major dietary source of phenolic compounds with health‐promoting properties. In particular, the demand for green and red oak‐leaf lettuces has considerably increased in the last years but few data on their polyphenol composition are available. Moreover, the usage of analytical edge technology can provide new structural information and allow the identification of unknown polyphenols. In the present study, the phenolic profiles of green and red oak‐leaf lettuce cultivars were exhaustively characterized by ultrahigh‐performance liquid chromatography (UHPLC) coupled online to diode array detection (DAD), electrospray ionization (ESI), and quadrupole time‐of‐flight mass spectrometry (QToF/MS), using the MSE instrument acquisition mode for recording simultaneously exact masses of precursor and fragment ions. One hundred fifteen phenolic compounds were identified in the acidified hydromethanolic extract of freeze‐dried lettuce leaves. Forty‐eight of these compounds were tentatively identified for the first time in lettuce, and only 20 of them have been previously reported in oak‐leaf lettuce cultivars in literature. Both oak‐leaf lettuce cultivars presented similar phenolic composition, except for apigenin‐glucuronide and dihydroxybenzoic acid, only detected in the green cultivar; and for luteolin‐hydroxymalonylhexoside, an apigenin conjugate with molecular formula C40H54O19 (monoisotopic MW = 838.3259 u), cyanidin‐3‐O‐glucoside, cyanidin‐3‐O‐(3″‐O‐malonyl)glucoside, cyanidin‐3‐O‐(6″‐O‐malonyl)glucoside, and cyanidin‐3‐O‐(6″‐O‐acetyl)glucoside, only found in the red cultivar. The UHPLC‐DAD‐ESI‐QToF/MSE approach demonstrated to be a useful tool for the characterization of phenolic compounds in complex plant matrices.
Circulation type classifications for temperature and precipitation stratification in Italy
Authors: Vallorani Roberto , Bartolini Giorgio , Betti Giulio , Crisci Alfonso , Gozzini Bernardo , Grifoni Daniele , Iannuccilli Maurizio , Messeri Alessandro , Messeri Gianni , Morabito Marco , Maracchi Giampiero 
Published: August 2017

ABSTRACTDuring the last few decades, weather circulation type classifications (CTCs) have been widely used to gain insight into processes at the synoptic scale, but also for studying the relationship between atmospheric circulation and surface climate variability. This study aims to evaluate the best performing CTCs based on COST733 software for the stratification of daily ground‐level precipitation and surface air temperature across Italy by means of four statistical metrics. Six classification methods belonging to the four COST733 groups (threshold‐based, PCA‐based, leader algorithms and optimization algorithms) were investigated on 32 and 26 data time series derived from Italian weather stations for daily mean temperature and daily mean precipitation, respectively. CTCs were computed using gridded mean sea level pressure and geopotential height at 500 hPa derived from the NCEP Reanalysis 2 dataset between 1979 and 2015 and tested on three different numbers of classes (8/9, 11/12 and 18 circulation types). Evaluation metrics showed an evident seasonal variability and high‐spatial heterogeneity reflecting the geographical complexity of the Italian territory. The study points out that the best classification, both for temperature and precipitation, is strongly dependent on the classification variable (mean sea level pressure and geopotential height at 500 hPa) showing relevant differences between surface temperature and precipitation. A low number of circulation types (8/9) resulted as the most appropriate grouping for the Italian domain and the Principal Component Transversal and Simulated Annealing were the best performing classification procedures for ground‐level precipitation and temperature stratification, respectively.
Phosphorus availability of sewage sludge‐based fertilizers determined by the diffusive gradients in thin films (DGT) technique
Authors: Vogel Christian , Sekine Ryo , Steckenmesser Daniel , Lombi Enzo , Steffens Diedrich , Adam Christian 
Published: August 2017

AbstractThe plant‐availability of phosphorus (P) in fertilizers and soil can strongly influence the yield of agricultural crops. However, there are no methods to efficiently and satisfactorily analyze the plant‐availability of P in sewage sludge‐based P fertilizers except by undertaking time‐consuming and complex pot or field experiments. We employed the diffusive gradients in thin films (DGT) technique to quantify the plant P availability of various types of P fertilizers with a novel focus on sewage sludge‐based P fertilizers. Mixtures of fertilizer and soil were incubated for 3 weeks at 60% water holding capacity. DGT devices were deployed at the beginning of the incubation and again after 1, 2, and 3 weeks. Two weeks of incubation were sufficient for the formation of plant‐available P in the fertilizer/soil mixtures. In a pot experiment, the DGT technique predicted maize (Zea mays L.) biomass yield and P uptake significantly more accurately than standard chemical extraction tests for P fertilizers (e.g., water, citric acid, and neutral ammonium citrate). Therefore, the DGT technique can be recommended as a reliable and robust method to screen the performance of different types of sewage sludge‐based P fertilizers for maize cultivation minimizing the need for time‐consuming and costly pot or field experiments.
Extra‐virgin olive oil: are consumers provided with the sensory quality they want? A hedonic price model with sensory attributes
Authors: Cavallo Carla , Caracciolo Francesco , Cicia Gianni , Del Giudice Teresa 
Published: August 2017

AbstractBACKGROUNDOver the years, niche‐differentiation strategies and food policies have pushed quality standards of European extra‐virgin olive oil towards a product that has a sensory profile consisting of fruity, bitter and pungent notes, with such oils having excellent healthy features. However, it is unclear whether typical consumers are ready for a richer and more complex sensory profile than the neutral one historically found on the market. This potential discrepancy is investigated in the present study aiiming to determine whether current demand is able to appreciate this path of quality enhancement. Implicit prices for each and every attribute of extra‐virgin olive oil with a focus on sensory characteristics were investigated using a hedonic price model.RESULTSAlthough confirming the importance of origin and terroir for extra‐virgin olive oil, the results of the present study strongly confirm the discrepancy between what is currently valued on the market and what novel supply trends are trying to achieve in terms of the sensory properties of such products.CONCLUSIONIncreasing consumer awareness about the direct link between the health quality of oils and their sensory profile appears to be necessary to make quality enhancement programs more successful on the market and hence more effective for companies. © 2017 Society of Chemical Industry
Dietary vitamin E dosage and source affects meat quality parameters in light weight lambs
Authors: Leal Leonel N , Beltrán José A , Alonso Verónica , Bello José M , den Hartog Leo A , Hendriks Wouter H , Martín‐Tereso Javier 
Published: August 2017

AbstractBACKGROUNDSupra‐nutritional vitamin E supplementation is a commonly used approach to delay lipid oxidation and colour deterioration in lamb and beef meat marketed under modified atmosphere packaging. However, these applications lack a precise calibration of dose for the desired effect and, in addition, limited information is available regarding the use of natural vitamin E for this purpose.RESULTSThree hundred and sixty Rasa Aragonesa lambs were fed diets supplemented with all‐rac‐α‐tocopheryl acetate (250, 500, 1000 and 2000 mg kg–1 compound feed), RRR‐α‐tocopheryl acetate (125, 250, 500 and 1000 mg kg–1 compound feed) and a basal diet without vitamin E supplementation for 14 days before slaughter at 25.8 ± 1.67 kg body weight. Vitamin E supplementation had no effect (P > 0.05) on average daily weight gain, feed intake and feed efficiency. Display time had larger effects on lipid oxidation, colour stability, myoglobin forms and meat discolouration parameters compared to vitamin E supplementation. However, vitamin E source and dosage significantly extended meat shelf‐life as indicated by lipid oxidation, redness, hue angle, metmyoglobin formation, deoxymyoglobin formation, A580–630 and ISO2.CONCLUSIONThe quantification of these effects demonstrated that the biological activity value of 1.36 used to distinguish both vitamin E sources is not appropriate for meat quality enhancing properties. © 2017 Society of Chemical Industry
Changes in shoulder muscle activity pattern on surface electromyography after breast cancer surgery
Authors: Yang Eun Joo , Kwon YoungOk 
Published: August 2017

Background and ObjectivesAlterations in muscle activation and restricted shoulder mobility, which are common in breast cancer patients, have been found to affect upper limb function. The purpose of this study was to determine muscle activity patterns, and to compare the prevalence of abnormal patterns among the type of breast surgery.MethodsIn total, 274 breast cancer patients were recruited after surgery. Type of breast surgery was divided into mastectomy without reconstruction (Mastectomy), reconstruction with tissue expander/implant (TEI), latissimus dorsi (LD) flap, or transverse rectus abdominis flap (TRAM). Activities of shoulder muscles were measured using surface electromyography. Experimental analysis was conducted using a Gaussian filter smoothing method with regression.ResultsPatients demonstrated different patterns of muscle activation, such as normal, lower muscle electrical activity, and tightness. After adjusting for BMI and breast surgery, the odds of lower muscle electrical activity and tightness in the TRAM are 40.2% and 38.4% less than in the Mastectomy only group. The prevalence of abnormal patterns was significantly greater in the ALND than SLNB in all except TRAM.ConclusionsAlterations in muscle activity patterns differed by breast surgery and reconstruction type. For breast cancer patients with ALND, TRAM may be the best choice for maintaining upper limb function.
Recurrence patterns and associated factors of locoregional failure following neoadjuvant chemoradiation and surgery for esophageal cancer
Authors: Blackham Aaron U. , H. Naqvi Syeda M. , Schell Michael J. , Jin William , Gangi Alexandra , Almhanna Khaldoun , Fontaine Jacques P. , Hoffe Sarah E. , Frakes Jessica , Venkat Puja , Pimiento Jose M. 
Published: August 2017

BackgroundDespite neoadjuvant chemoradiation (nCRT) followed by esophagectomy for locally advanced esophageal cancer, locoregional recurrence (LRR) is common and factors associated with LRR have not been clearly identified.MethodsPatients were identified from a single institution, prospectively maintained database (1996‐2013). Patterns of recurrence were described and associated factors of LRR were analyzed using competing risks regression models.ResultsOf the 456 patients treated with nCRT and surgery, 167 patients developed recurrence. Locoregional and distant recurrences were observed in 69 (15.1%) and 140 (30.9%) patients, respectively. Time to recurrence (13.6 vs 10.4 months, P = 0.20) and median overall survival (29.3 vs 19.1 months, P = 0.12) were no different among the 27 patients (6%) who developed a solitary LRR compared to patients who developed distant recurrence. Univariable analysis identified lymphovascular invasion (HR 1.46, P = 0.07), lymph node ratio >0.5 (HR 2.16, P = 0.02), positive margin (HR 1.95, P = 0.05), lack of response to neoadjuvant therapy (HR 1.99, P < 0.01), clinical T stage (HR 2.62, P < 0.01) and final T3/4 stage (HR 2.06, P < 0.01) as factors significantly associated with LRR. Clinical T stage and response to neoadjuvant treatment were independently associated with LRR on multivariable analysis.ConclusionsAlthough aggressive tumor biology plays a significant role in LRR, optimizing neoadjuvant treatments to obtain a complete pathologic response may lead to improved locoregional control.