bluuebunny/crossref_metadata_2025_split huggingface dataset:
Particle acceleration in relativistic magnetic flux-merging events
Authors: Lyutikov Maxim , Sironi Lorenzo , Komissarov Serguei S. , Porth Oliver 
Published: January 2018

Using analytical and numerical methods (fluid and particle-in-cell simulations) we study a number of model problems involving merger of magnetic flux tubes in relativistic magnetically dominated plasma. Mergers of current-carrying flux tubes (exemplified by the two-dimensional ‘ABC’ structures) and zero-total-current magnetic flux tubes are considered. In all cases regimes of spontaneous and driven evolution are investigated. We identify two stages of particle acceleration during flux mergers: (i) fast explosive prompt X-point collapse and (ii) ensuing island merger. The fastest acceleration occurs during the initial catastrophic X-point collapse, with the reconnection electric field of the order of the magnetic field. During the X-point collapse, particles are accelerated by charge-starved electric fields, which can reach (and even exceed) values of the local magnetic field. The explosive stage of reconnection produces non-thermal power-law tails with slopes that depend on the average magnetization $\unicode[STIX]{x1D70E}$. For plasma magnetization $\unicode[STIX]{x1D70E}\leqslant 10^{2}$ the spectrum power-law index is $p>2$; in this case the maximal energy depends linearly on the size of the reconnecting islands. For higher magnetization, $\unicode[STIX]{x1D70E}\geqslant 10^{2}$, the spectra are hard, $p<2$, yet the maximal energy $\unicode[STIX]{x1D6FE}_{\text{max}}$ can still exceed the average magnetic energy per particle, ${\sim}\unicode[STIX]{x1D70E}$, by orders of magnitude (if $p$ is not too close to unity). The X-point collapse stage is followed by magnetic island merger that dissipates a large fraction of the initial magnetic energy in a regime of forced magnetic reconnection, further accelerating the particles, but proceeds at a slower reconnection rate.
Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation
Authors: Donohoe G. , Holland J. , Mothersill D. , McCarthy-Jones S. , Cosgrove D. , Harold D. , Richards A. , Mantripragada K. , Owen M. J. , O'Donovan M. C. ,   WTCCC2, Gill M. , Corvin A. , Morris D. W. 
Published: January 2018

AbstractBackgroundThe longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component 4 (C4) gene. This structural variation generates varying levels of C4 RNA expression, and genetic information from the MHC region can now be used to predict C4 RNA expression in the brain. Increased predicted C4A RNA expression is associated with the risk of SZ, and C4 is reported to influence synaptic pruning in animal models.MethodsBased on our previous studies associating MHC SZ risk variants with poorer memory performance, we tested whether increased predicted C4A RNA expression was associated with reduced memory function in a large (n = 1238) dataset of psychosis cases and healthy participants, and with altered task-dependent cortical activation in a subset of these samples.ResultsWe observed that increased predicted C4A RNA expression predicted poorer performance on measures of memory recall (p = 0.016, corrected). Furthermore, in healthy participants, we found that increased predicted C4A RNA expression was associated with a pattern of reduced cortical activity in middle temporal cortex during a measure of visual processing (p < 0.05, corrected).ConclusionsThese data suggest that the effects of C4 on cognition were observable at both a cortical and behavioural level, and may represent one mechanism by which illness risk is mediated. As such, deficits in learning and memory may represent a therapeutic target for new molecular developments aimed at altering C4’s developmental role.
How do social security expenditures vary by state? The surprising impact of unemployment
Authors: Chaffin LaTasha Y. , Corder J. Kevin 
Published: January 2018

AbstractWe examine state-level variation in the flow of benefits under the largest Social Security programme – the Old-Age (OA) programme. OA pensions remain a robust and growing component of the American social safety net. Although OA pensions are entirely administered by the federal government, state-level demographic features can imply different aggregate levels of programme expenditures across states. We describe high levels of variation in the resources flowing into states from the OA programme and we find relationships between state features that might seem only remotely related to income support for the elderly: current unemployment rates, previous income levels, poverty rates and minority populations. We find a particularly strong link between current unemployment rates, OA coverage and OA average benefits. The number of recipients and the level of average OA payments increase when unemployment increases. This is a poorly understood but important feature of the OA programme.
What Do Clinical Supervisors Require to Teach Residents in Family Medicine How to Care for Seniors?
Authors: Giguere Anik M. C. , Lebel Paule , Morin Michèle , Proust Françoise , Rodríguez Charo , Carnovale Valerie , Champagne Louise , Légaré France , Carmichael Pierre-Hugues , Martineau Bernard , Karazivan Philippe , Durand Pierre J. 
Published: January 2018

RÉSUMÉNous avons évalué les besoins de formation des cliniciens qui supervisent les résidents dans les cliniques d’enseignement de médecine familiale au Québec. Nous avons utilisé une méthodologie mixte comprenant: un balayage environnemental des programmes de formation des Départements de médecine familiale, un consensus d’experts pour sélectionner des situations cliniques prioritaires pour les soins aux aînés, un questionnaire pour connaître la perception des superviseurs de leurs besoins de formation, et des entrevues pour comprendre les raisons des besoins. Partant du balayage, les experts ont identifié 13 situations cliniques prioritaires. Les 352 participants au sondage (taux de réponse : 36 %) ont rapporté des besoins plus importants pour gérer les symptômes comportementaux et psychologiques de la démence, la polymédication, la dépression, et les troubles cognitifs. Les entrevues ont révélé que ces situations cliniques étaient parfois complexes à diagnostiquer et à gérer en raison de leurs aspects psychosociaux, de la communication avec les patients et les familles, et de la coordination des équipes interprofessionnelles. Les superviseurs ont également rapporté des besoins plus important en milieu soins de longue durée et à domicile par rapport aux soins ambulatoires, dû à la complexité des soins aux aînés dans ces milieux et à la présence de proches aidants.
Molecular characterisation of measles virus strains among refugees from Central African Republic in Cameroon in 2014
Authors: Ndombo P. K. , Ndze V. N. , Mbarga F. D. , Anderson R. , Acho A. , Ebua Chia J. , Njamnshi A. K. , Rota P. A. , Waku-Kouomou D. 
Published: January 2018

AbstractMeasles is a highly infectious human viral disease caused by measles virus (MeV). An estimated 114 900 measles deaths occurred worldwide in 2014. There are currently eight clades (A–H) comprised 24 MeV genotypes. We sought to characterise MeVs among Central African Republic (CAR) refugees during the 2014 measles epidemic in Cameroon. Samples were collected from children <15 years with suspected measles infections in two refugee camps in the east region of Cameroon. Viral RNA was extracted directly from urine samples. RNA detection of MeV RNA was performed with real-time reverse transcription polymerase chain reaction (PCR) to amplify a 634 bp nucleotide fragment of the N gene. The sequence of the PCR product was obtained to determine the genotype. MeV RNA was detected in 25 out of 30 samples from suspected cases, and among the 25 positive samples, MeV sequences were obtained from 20. The MeV strains characterised were all genotype B3. The MeV strains from genotype B3 found in this outbreak were more similar to those circulating in Northern Cameroon in 2010–2011 than to MeV strains circulating in the CAR in 2011. Surveillance system should be improved to focus on refugees for early detection of and response to outbreaks.
Utility of arterial stiffness assessment in children
Authors: Panchangam Chaitanya , Merrill Eric Dean , Raghuveer Geetha 
Published: January 2018

AbstractAtherosclerotic cardiovascular disease is a leading cause of death and disability worldwide, and the atherosclerotic process begins in childhood. Prevention or containment of risk factors that accelerate atherosclerosis can delay the development of atherosclerotic cardiovascular disease. Although current recommendations are to periodically screen for commonly prevailing risk factors for atherosclerosis in children, a single test that could quantify the cumulative effect of all risk factors on the vasculature, thus assessing arterial health, would be helpful in further stratifying risk. Measurement of pulse wave velocity and assessment of augmentation index – measures of arterial stiffness – are easy-to-use, non-invasive methods of examining arterial health. Various studies have assessed pulse wave velocity and augmentation index in children with commonly occurring conditions including obesity, hypertension, insulin resistance, diabetes mellitus, dyslipidaemia, physical inactivity, chronic kidney disease, CHD and acquired heart diseases, and in children who were born premature or small for gestational age. This article summarises pulse wave velocity and augmentation index assessments and the effects of commonly prevailing chronic conditions on arterial health in children. In addition, currently available reference values for pulse wave velocity and augmentation index in healthy children are included. Further research to establish widely applicable normative values and the effect of lifestyle and pharmacological interventions on arterial health in children is needed.
New public management in Iran’s health complex: a management framework for primary health care system
Authors: Tabrizi Jafar Sadegh , HaghGoshayie Elaheh , Doshmangir Leila , Yousefi Mahmood 
Published: January 2018

BackgroundNew public management (NPM) was developed as a management reform to improve the efficiency and effectiveness in public organizations, especially in health sector. Using the features of private sector management, the managers of health organizations may try to implement the elements of NPM with the hope to improve the performance of their systems.AimsOur aim in the present study was to identify the elements and infrastructures suitable for implementing NPM in the Iranian health complex.MethodIn this qualitative study with conventional content analysis approach, we tried to explore the NPM elements and infrastructures in Iranian public health sector. A series of semi-structured interviews (n=48) were conducted in 2016 with a managers in public and private health complex. Three focus group discussions with nine faculty members were also conducted. A data collection form was used to collect the demographic characteristics and perspectives of the participants.FindingsFrom the perspective of managers, managerialism, decentralization, using market mechanism, performance management, customer orientation and performance budgeting were the main elements of NPM in the Iranian context. The most important infrastructures for implementing this reform were as follows: education and training, information technology, the proper use of human resources, decision support systems, top management commitment, organizational culture, flexibility of rules, rehabilitating of the aging infrastructures, and expanding the coverage of services.ConclusionThe NPM was generally identified to be an effective replacement for the traditional administration method. These reforms may be helpful in strengthening the public health complex and the management capacity, as well. NPM also seems to be useful in interacting the public health sector with the private sector in terms of personnel and resources, performance, reward structure, and methods of doing business.
First caddisflies (Trichoptera) in Lower Cretaceous Lebanese amber
Authors: Wichard Wilfried , Azar Dany 
Published: January 2018

ABSTRACTLebanese amber contains a diverse biota from the Lower Cretaceous, and more than 150 families of arthropods have been reported as inclusions. Amongst these, caddisflies (Trichoptera) are very scarce inclusions, consisting of a few indeterminate fragments and only two inclusions that permit clear descriptions of new species. We describe the first two Trichoptera species from Lebanese amber, belonging respectively to Dipseudopsidae (Phylocentropus succinolebanensis n. sp.) and Ecnomidae (Ecnomus cretacia n. sp.). Previously, the oldest fossil representatives of both families were known from the Upper Cretaceous amber of New Jersey for Dipseudopsidae and from the Eocene Baltic amber for Ecnomidae.
Infrastructure in the Making: The Chao Phraya Dam and the Dance of Agency
Authors: Sangkhamanee Jakkrit 
Published: January 2018

AbstractThe article explores the process behind the construction of the Chao Phraya Dam, the first World Bank-funded water infrastructure project in Thailand, developed during the 1950s. Employing Andrew Pickering's ‘dance of agency’ concept in examining the process of turning financial and technical assistance into a workable project, I argue that development infrastructure, like the Chao Phraya Dam, provides a space to explore the dialectic operations – accommodation and resistance – of agency and the unstable associations among diverse actors, expertise, institutions, and materials, as well as practices. Recounting the history of the dam in the making, I explore a series of entanglements through different dances of agency, namely initiation, assessment, mobilisation, negotiation, adjustment, confrontation, and settlement. Such a multiplicity of dancesinsideandin the makingof infrastructure reflects the techno-political entanglement encompassing the manifold negotiation and adjustment of conflicting goals, interests, recognition, and cooperation among different agencies. The dam, often portrayed as an engineering achievement of the state, is in fact the result of unanticipated relations and the responses to the temporal emerging forms of practices.
Weed Communities in Semiarid Rainfed Croplands of Central Argentina: Comparison between Corn (Zea mays) and Soybean (Glycine max) Crops
Authors: Rauber Ruth B. , Demaría Manuel R. , Jobbágy Esteban G. , Arroyo Daniel N. , Poggio Santiago L. 
Published: January 2018

AbstractThe semiarid Espinal in central Argentina, being recently transformed from natural semiarid grasslands into agriculture, represents an interesting scenario to understand the early stages of weed community assembly and its relationship with crop identity and management. Our aim was to characterize the weed communities in corn (Zea maysL.) and soybean [Glycine max(L.) Merr.], the main crops of the Espinal region, under the dominant rainfed conditions. Weed surveys were carried out in 53 fields, and farmers were interviewed to collect information about crop management. Floristic composition was compared within and between crops by calculating the additive partition of the abundance-based Bray-Curtis dissimilarity. We compared the frequency and mean cover of functional groups between crops through generalized linear models. Finally, canonical correspondence analysis was carried out to analyze the associations between floristic composition and agronomic variables. Mean alpha and gamma diversity was greater in corn (10.0 and 80 species, respectively) than in soybean (7.6 and 46 species, respectively). Furthermore, species composition of weed communities was more similar among soybean fields than among either cornfields or fields of both crops. Hence, floristic differences between crops are potentially the result of different microenvironmental heterogeneity above- and belowground, with corn likely to be more permissive to weed establishment compared with soybean. The higher frequency of annual, dicotyledonous, and native species, and the high proportion of rare species, mostly native, suggest a strong legacy of the original vegetation that thrived in these recently cultivated systems. The functional composition was also affected by agronomic management, with sulfur, nitrogen, and grass herbicide application being the most important factors related to the floristic composition of weed communities. This early description can be used as a starting point for studies concerning trajectories, mechanisms, and processes of weed communities related to environment and management.
Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention
Authors: Lieberman J A , Girgis R R , Brucato G , Moore H , Provenzano F , Kegeles L , Javitt D , Kantrowitz J , Wall M M , Corcoran C M , Schobel S A , Small S A 
Published: January 2018

AbstractScientists have long sought to characterize the pathophysiologic basis of schizophrenia and develop biomarkers that could identify the illness. Extensive postmortem and in vivo neuroimaging research has described the early involvement of the hippocampus in the pathophysiology of schizophrenia. In this context, we have developed a hypothesis that describes the evolution of schizophrenia—from the premorbid through the prodromal stages to syndromal psychosis—and posits dysregulation of glutamate neurotransmission beginning in the CA1 region of the hippocampus as inducing attenuated psychotic symptoms and initiating the transition to syndromal psychosis. As the illness progresses, this pathological process expands to other regions of the hippocampal circuit and projection fields in other anatomic areas including the frontal cortex, and induces an atrophic process in which hippocampal neuropil is reduced and interneurons are lost. This paper will describe the studies of our group and other investigators supporting this pathophysiological hypothesis, as well as its implications for early detection and therapeutic intervention.
Gut microbiome populations are associated with structure-specific changes in white matter architecture
Authors: Ong Irene M. , Gonzalez Jose G. , McIlwain Sean J. , Sawin Emily A. , Schoen Andrew J. , Adluru Nagesh , Alexander Andrew L. , Yu John-Paul J. 
Published: January 2018

AbstractAltered gut microbiome populations are associated with a broad range of neurodevelopmental disorders including autism spectrum disorder and mood disorders. In animal models, modulation of gut microbiome populations via dietary manipulation influences brain function and behavior and has been shown to ameliorate behavioral symptoms. With striking differences in microbiome-driven behavior, we explored whether these behavioral changes are also accompanied by corresponding changes in neural tissue microstructure. Utilizing diffusion tensor imaging, we identified global changes in white matter structural integrity occurring in a diet-dependent manner. Analysis of 16S ribosomal RNA sequencing of gut bacteria also showed changes in bacterial populations as a function of diet. Changes in brain structure were found to be associated with diet-dependent changes in gut microbiome populations using a machine learning classifier for quantitative assessment of the strength of microbiome-brain region associations. These associations allow us to further test our understanding of the gut-brain-microbiota axis by revealing possible links between altered and dysbiotic gut microbiome populations and changes in brain structure, highlighting the potential impact of diet and metagenomic effects in neuroimaging.
Common basis for orofacial clefting and cortical interneuronopathy
Authors: Ansen-Wilson Lydia J. , Everson Joshua L. , Fink Dustin M. , Kietzman Henry W. , Sullivan Ruth , Lipinski Robert J. 
Published: January 2018

AbstractOrofacial clefts (OFCs) of the lip and/or palate are among the most common human birth defects. Current treatment strategies focus on functional and cosmetic repair but even when this care is available, individuals born with OFCs are at high risk for persistent neurobehavioral problems. In addition to learning disabilities and reduced academic achievement, recent evidence associates OFCs with elevated risk for a constellation of psychiatric outcomes including anxiety disorders, autism spectrum disorder, and schizophrenia. The relationship between these outcomes and OFCs is poorly understood and controversial. Recent neuroimaging studies in humans and mice demonstrate subtle morphological brain abnormalities that co-occur with OFCs but specific molecular and cellular mechanisms have not been investigated. Here, we provide the first evidence directly linking OFC pathogenesis to abnormal development of GABAergic cortical interneurons (cINs). Lineage tracing revealed that the structures that form the upper lip and palate develop in molecular synchrony and spatiotemporal proximity to cINs, suggesting these populations may have shared sensitivity to genetic and/or teratogenic insult. Examination of cIN development in a mouse model of nonsyndromic OFCs revealed significant disruptions in cIN proliferation and migration, culminating in misspecification of the somatostatin-expressing subgroup. These findings reveal a unified developmental basis for orofacial clefting and disrupted cIN development, and may explain the significant overlap in neurobehavioral and psychiatric outcomes associated with OFCs and cIN dysfunction. This emerging mechanistic understanding for increased prevalence of adverse neurobehavioral outcomes in OFC patients is the entry-point for developing evidence-based therapies to improve patient outcomes.
Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons
Authors: Wang Ping , Zhao Dejian , Lachman Herbert M. , Zheng Deyou 
Published: January 2018

AbstractAutism spectrum disorder (ASD) is highly heritable but genetically heterogeneous. The affected neural circuits and cell types remain unclear and may vary at different developmental stages. By analyzing multiple sets of human single cell transcriptome profiles, we found that ASD candidates showed relatively enriched gene expression in neurons, especially in inhibitory neurons. ASD candidates were also more likely to be the hubs of the co-expression gene module that is highly expressed in inhibitory neurons, a feature not detected for excitatory neurons. In addition, we found that upregulated genes in multiple ASD cortex samples were enriched with genes highly expressed in inhibitory neurons, suggesting a potential increase of inhibitory neurons and an imbalance in the ratio between excitatory and inhibitory neurons in ASD brains. Furthermore, the downstream targets of several ASD candidates, such as CHD8, EHMT1 and SATB2, also displayed enriched expression in inhibitory neurons. Taken together, our analyses of single cell transcriptomic data suggest that inhibitory neurons may be a major neuron subtype affected by the disruption of ASD gene networks, providing single cell functional evidence to support the excitatory/inhibitory (E/I) imbalance hypothesis.