bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using the Translational Science Benefits Model to assess the impact of the Penn Implementation Science Center in Cancer Control
Authors: Schnoll Robert , Bekelman Justin E. , Blumenthal Daniel , Asch David A. , Buttenheim Alison M. , Chaiyachati Krisda H. , Domchek Susan M. , Fayanju Oluwadamilola M. , Gabriel Peter , Jenssen Brian P. , Leone Frank T. , McCarthy Anne Marie , Nathanson Katherine L. , Parikh Ravi B. , Rendle Katharine A. , Shelton Rachel C. , Shulman Lawrence N. , Takvorian Samuel U. , Ware Susan , Wileyto E. Paul , Beidas Rinad S. 
Published: October 2024

Abstract
Traditional approaches for evaluating the impact of scientific research – mainly scholarship (i.e., publications, presentations) and grant funding – fail to capture the full extent of contributions that come from larger scientific initiatives. The Translational Science Benefits Model (TSBM) was developed to support more comprehensive evaluations of scientific endeavors, especially research designed to translate scientific discoveries into innovations in clinical or public health practice and policy-level changes. Here, we present the domains of the TSBM, including how it was expanded by researchers within the Implementation Science Centers in Cancer Control (ISC3) program supported by the National Cancer Institute. Next, we describe five studies supported by the Penn ISC3, each focused on testing implementation strategies informed by behavioral economics to reduce key practice gaps in the context of cancer care and identify how each study yields broader impacts consistent with TSBM domains. These indicators include Capacity Building, Methods Development (within the Implementation Field) and Rapid Cycle Approaches, implementing Software Technologies, and improving Health Care Delivery and Health Care Accessibility. The examples highlighted here can help guide other similar scientific initiatives to conceive and measure broader scientific impact to fully articulate the translation and effects of their work at the population level.
Mixed-Functions IoT devices: a Regulatory and Liability Requirements’ Maze. A First Overview
Authors: Gennari Francesca 
Published: October 2024

AbstractThis early-stage research article intends to explore the regulatory and liability requirements of a not yet fully developed subset of consumer Internet of Things (IoT) objects: the mixed-functions IoT devices. These objects could be wearables or not but could perform an e-health function, such as measuring your heartbeat, as well as consumer functions, such as displaying chat notifications. I argue that these mixed-functions devices will play an important role within smart homes as they will interact with new medical IoT devices to carry on rehabilitation and other medical functions at home. That is why it is important to start mapping down all the regulatory and liability requirements that might interest mixed-functions IoT device developers for them to understand which thread to follow in this regulatory and liability requirements maze.
Validation of electronic health record data to identify hospital-associated Clostridioides difficile infections for retrospective research
Authors: Ray Michael J. , Lacanilao Kathleen L. , Lazaro Maela Robyne , Strnad Luke C. , Furuno Jon P. , Royster Kelly , McGregor Jessina C. 
Published: October 2024

AbstractClostridioides difficile infection (CDI) research relies upon accurate identification of cases when using electronic health record (EHR) data. We developed and validated a multi-component algorithm to identify hospital-associated CDI using EHR data and determined that the tandem of CDI-specific treatment and laboratory testing has 97% accuracy in identifying HA-CDI cases.
Lethal and sublethal concentrations spirodiclofen stress may increase the adaptation of Panonychus citri (Acari: Tetranychidae)
Authors: Wang Hongyan , Wang Haifeng , Wen Kexin , Xie Tao , Luo Shigan , Wu Jiawei , Xia Bin 
Published: October 2024

AbstractPanonychus citri is one of the most destructive pests in citrus orchards, exhibiting varying degrees of tolerance to numerous insecticides, such as spirodiclofen. To effectively manage pests, this study explores the response of P. citri to spirodiclofen stress from the perspectives of life history, enzymatic parameters, and reproduction. The effects of two concentrations (LC30 and LC50) of spirodiclofen on the biological parameters of P. citri were evaluated by the life table method. The results showed that the development duration, fecundity, oviposition days, and lifespan were shortened, though the pre-oviposition period of two treatments was prolonged in comparison with the control. A significant decrease was recorded in the net reproductive rate (R0) and the mean generation time (T) for the two treatments. Nevertheless, the intrinsic rate of increase (r) and the rate of increase (λ) were not significantly affected in the LC30 treatment, whereas they declined in the LC50 treatment. The enzyme activity assay resulted in higher activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and carboxylesterase (CarE), among the treatments than the control. In contrast, the treatments recorded lower cytochromeP450 (CYP450) and Glutathione S-transferase (GST) activities than the control. Furthermore, the study detected that relative mRNA expression of Vitellogenin (Vg) and Vitellogenin receptor (VgR) for two treatments were lower than the control. In summary, two concentrations of spirodiclofen inhibited progeny growth and fecundity of P. citri. Additionally, the results of this study may support further research on tolerance of P. citri in response to spirodiclofen stress.
Understanding the Good: Medieval Inquisitions and Modern Religion
Authors: Ames Christine Caldwell 
Published: October 2024

Abstract
This essay responds to scholarly arguments that “religion” arose in the particular circumstances of the modern West, distinct chronologically and conceptually from medieval religio. It argues that in the Middle Ages, Christian persecution helped to form that very notion of religion. It does so via the register of heresy inquisitions conducted by Bishop Jacques Fournier in Pamiers (1318–1325), which contains a curious and overlooked Occitan phrase: entendensa del be (“understanding of the good”). In three provocative ways, entendensa del be helps us to reconsider the origins of “religion.” First, one possibility is that the phrase represents an organic proto-religion among the heretics known as Good Christians. A second possibility is, conversely, that scribes presented an insignificant phrase as a technical term, helping to identify the group as heretical. This would highlight coercive inquisitorial agency in reinterpreting language and behavior, anticipating early-modern and modern constructors of “religion.” Third, by its links to troubadour culture, the phrase reminds us how in Occitania, conquest and resistance intertwined with inquisition's policing of “religious” behavior in a way that resembles claims for modernity. Regardless of which possibility, and most importantly, we discover how medieval persecution helped to form modern religion.
An Altar from Marton, Lincolnshire, and a Soldier of Leg. XI Claudia in Britain
Authors: Buckland Paul C. , Dolby Malcolm J. 
Published: October 2024

AbstractAn altar to Mars dedicated by a soldier of legio XI Claudia is shown to have been removed from the fabric of Marton church during restoration work and, along with much of the other stone for the Romanesque tower, nave and chancel probably derived from the Roman small town of Segelocum, Littleborough on Trent. The name of the dedicator, G. IVLIVS ANTONINUS, is discussed in the context of legio XI Claudia deployment on the Lower Danube.
Lower limb exoskeleton for gait rehabilitation with adaptive nonsingular sliding mode control
Authors: Centeno-Barreda Daniel , Salazar-Cruz Sergio , López-Gutiérrez Ricardo , Rosales-Luengas Yukio , Lozano Rogelio 
Published: October 2024

AbstractThis paper introduces a lower limb exoskeleton for gait rehabilitation, which has been designed to be adjustable to a wide range of patients by incorporating an extension mechanism and series elastic actuators (SEAs). This configuration adapts better to the user’s anatomy and the natural movements of the user’s joints. However, the inclusion of SEAs increases actuator mass and size, while also introducing nonlinearities and changes in the dynamic response of the exoskeletons. To address the challenges related to the human–exoskeleton dynamic interaction, a nonsingular terminal sliding mode control that integrates an adaptive parameter adjustment strategy is proposed, offering a practical solution for trajectory tracking with uncertain exoskeleton dynamics. Simulation results demonstrate the algorithm’s ability to estimate unknown parameters. Experimental tests analyze the performance of the controller against uncertainties and external disturbances.
Neuropsychological outcomes following endovascular clot retrieval and intravenous thrombolysis in ischemic stroke
Authors: Humphrey Sam , Pike Kerryn E. , Long Brian , Ma Henry , Bourke Robert , Wright Bradley J. , Wong Dana 
Published: October 2024

AbstractObjectives:Cognitive impairment, anxiety, depression, fatigue, and dependence in instrumental activities of daily living (ADL) are common after stroke; however, little is known about how these outcomes may differ following treatment with endovascular clot retrieval (ECR), intravenous tissue plasminogen activator (t-PA), or conservative management.Methods:Patients were recruited after acute treatment and invited to participate in an outcome assessment 90–120 days post-stroke. The assessment included a cognitive test battery and several questionnaires. The COVID-19 pandemic led to significant disruptions in recruitment and data collection, and the t-PA and conservative management groups were combined into a standard medical care (SMC) group.Results:Sixty-two participants were included in the study (ECR = 31, SMC = 31). Mean age was 66.5 (20–86) years, and 35 (56.5%) participants were male. Participants treated with ECR had significantly higher National Institutes of Health Stroke Scale scores at presentation and significantly lower education. After adjusting for stroke severity, premorbid intellectual ability, and age, treatment with ECR was associated with significantly better performances on measures of cognitive screening, visual working memory, and verbal learning and memory. Participants treated with ECR also experienced less fatigue and were more likely to achieve independence in basic and instrumental ADLs. Despite this, cognitive impairment and fatigue were still common among participants treated with ECR and anxiety and depression symptoms were experienced similarly by both groups.Conclusions:Cognitive impairment and fatigue were less common but still prevalent following treatment with ECR. This has important practical implications for stroke rehabilitation, and routine assessment of cognition, emotion, and fatigue is recommended for all stroke survivors regardless of stroke treatment and functional outcome.
Environmental shocks and agriculture: implications of floods on labor market outcomes
Authors: Kamble Vikrant K. , Paudel Jayash , Mishra Ashok K. 
Published: October 2024

AbstractFloods often displace people and exacerbate their access to finance, affecting the livelihood of daily wage workers in least-developed countries. In August 2017, Nepal experienced the heaviest rainfall in more than 60 years, severely flooding about 80 per cent of the land in the southern part of the country. Using the two-way fixed effects approach and an event study design, we evaluate the impact of severe flooding on the wages of agricultural workers. We show that the 2017 floods resulted in a 9–10 per cent decrease in cash wages among agricultural households while in-kind wages of agricultural laborers increased significantly after the floods, implying that in-kind wages helped mitigate the adverse effects of floods on cash wages. We also investigate changes in assistance, loan-seeking behavior, loan repayment, and collection behavior as mechanisms leading to the risk-mitigating behavior by farmers.
Women’s Legislative Representation and Human Rights Treaty Ratification
Authors: Senk Kaitlin , Coulombe Nicholas M. , Edry Jessica 
Published: October 2024

AbstractDo recent increases in women’s representation around the world have implications for international relations? We argue that greater representation of women in legislatures increases the likelihood of human rights treaty ratification for two reasons. First, given their shared gendered experiences of exclusion and discrimination, women legislators will advocate on behalf of marginalized groups on an international scale as transnational surrogate representatives. Second, women legislators may be more inclined to prioritize the ratification of human rights treaties because these treaties align with their domestic policy preferences, which aim to support marginalized groups. We contend that, in countries where ratification depends upon legislative approval, legislatures are more likely to ratify human rights treaties as women’s presence increases. Using an original dataset of 201 multilateral treaties, we find that countries become more likely to ratify human rights treaties as levels of women’s legislative representation increase.
Significance of Urea in Sustaining Nitrite Production by Ammonia Oxidizers in the Oligotrophic Ocean
Authors: Wan Xianhui S. , Sheng Hua‐Xia , Shen Hui , Zou Wenbin , Tang Jin‐Ming , Qin Wei , Dai Minhan , Kao Shuh‐Ji , Ward Bess B. 
Published: October 2024

AbstractNitrification, the stepwise oxidation of ammonia to nitrate via nitrite, is a key process in the marine nitrogen cycle. Reported nitrite oxidation rates frequently exceed ammonia oxidation rates below the euphotic zone, raising the fundamental question of whether the two steps are balanced and if alternative sources contribute to nitrite production in the dark ocean. Here we present vertically resolved profiles of ammonia, urea, and nitrite oxidation rates and their kinetic traits in the oligotrophic Subtropical North Pacific. Our results show active urea‐derived nitrogen oxidation (urea‐N oxidation) in the presence of experimental ammonium amendment, suggesting direct urea utilization. The depth‐integrated rates of urea‐N oxidation and ammonia oxidation are comparable, demonstrating that urea‐N oxidation is a significant source of nitrite. The additional nitrite from urea‐N oxidation helps to balance the two steps of nitrification in our study region. Nitrifiers exhibit high affinity for their substrates, and the apparent half‐saturation constants for ammonia and nitrite oxidation decrease with depth. The apparent half‐saturation constant for urea‐N oxidation is higher than that for ammonia oxidation and shows no clear vertical trend. Such kinetic traits may account for the relatively higher urea concentration than ammonium concentration in the ocean's interior. Moreover, a compilation of our results and reported data shows a trend of increased urea‐N oxidation relative to ammonia oxidation from the eutrophic coastal zone to the oligotrophic open ocean. This trend reveals a substrate‐dependent biogeographic distribution of urea‐N oxidation across marine environments and provides new information on the balance and flux of the marine nitrification process.
Initiation of Downward Positive Leader Beneath the Negative Leader Channel
Authors: Zhu Jiangwan , Yuan Shanfeng , Qie Xiushu , Jiang Rubin , Liu Mingyuan , Feng Guili , Wang Yu 
Published: October 2024

AbstractDue to the weak radiation generated by positive leaders, our understanding of how positive leaders are initiated and reach the ground remains limited. This study investigated positive cloud‐to‐ground (CG) lightning induced after the long intracloud lightning based on high‐speed video and fast antenna mapping results. Below the cloud base in the field of view, re‐breakdowns of decayed negative branches occurred consecutively beneath the horizontal negative channel in the form of bidirectional leaders. These bidirectional leaders advanced along the same channel, and eventually, the third reached the ground, generating a positive return stroke (RS) with a peak current of 157 kA. Following the RS, new negative discharges emerge adjacent to the vertical return stroke channel, persisting and propagating to form a continuing current (CC) lasting over 200 milliseconds.
Comparative Impact of Fog and Rainfall on Vegetation in a Foggy Desert
Authors: Qiao Na , Wang Honglang , Li Yue , Wang Lixin 
Published: October 2024

AbstractFog is an important water source that alleviates vegetation water stress, especially for dryland ecosystems. Comprehensive knowledge of fog and rainfall effects can help us better understand dryland vegetation responses to current and future climates. However, the differences between fog and rainfall effects on vegetation are poorly understood. This study compared the effects of fog and rainfall on vegetation greenness changes based on the ground‐level meteorological observations in the Namib Desert and the satellite vegetation index. The vegetation index and its first derivative were utilized to indicate vegetation greenness and its change rate, respectively. Results showed that fog played a more significant role than rainfall in explaining vegetation greenness change rates, while accumulated rainfall was more important than fog in determining vegetation greenness. Soil temperature was an important factor in explaining vegetation greenness changes. These findings offer key insights into how fog and rainfall differentially contribute to vegetation greenness changes.
Tandem light-emitting technology accelerates the commercial application of perovskite LEDs
Authors: Zhang Xiang , Luo Jiajun , Chen Enguo , Mohd Yusoff Abd. Rashid bin 
Published: October 2024

AbstractHybrid tandem perovskite-organic LED has been developed to achieve high external quantum efficiency, narrow linewidth, and extended device lifespan, which shows great promise for future perovskite-EL-based commercial applications.
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
Authors: Xie Lin , Xue Fei , Cheng Cheng , Sui Wenhai , Zhang Jie , Meng Linlin , Lu Yue , Xiong Wenjing , Bu Peili , Xu Feng , Yu Xiao , Xi Bo , Zhong Lin , Yang Jianmin , Zhang Cheng , Zhang Yun 
Published: October 2024

AbstractThe pathogenesis of doxorubicin-induced cardiomyopathy remains unclear. This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 may ameliorate doxorubicin-induced cardiomyopathy. C57BL/6J mice were intraperitoneally injected with a cumulative dose of doxorubicin to induce cardiomyopathy. Cardiomyocyte-specific ADAM17-knockout (A17α-MHCKO) and ADAM17-overexpressing (AAV9-oeA17) mice were generated. In addition, RNA sequencing of the heart tissues in different mouse groups and in vitro experiments in neonatal rat cardiomyocytes (NRCMs) receiving different treatment were performed. Mouse tumor models were constructed in A17fl/fl and A17α-MHCKO mice. In addition, cardiomyocyte-specific TRAF3-knockdown and TRAF3-overexpressing mice were generated. ADAM17 expression and activity were markedly upregulated in doxorubicin-treated mouse hearts and NRCMs. A17α-MHCKO mice showed less cardiomyocyte apoptosis induced by doxorubicin than A17fl/fl mice, and cardiomyocyte ADAM17 deficiency did not affect the anti-tumor effect of doxorubicin. In contrast, AAV9-oeA17 mice exhibited markedly aggravated cardiomyocyte apoptosis relative to AAV9-oeNC mice after doxorubicin treatment. Mechanistically, doxorubicin enhanced the expression of transcription factor C/EBPβ, leading to increased expression and activity of ADAM17 in cardiomyocyte, which enhanced TNF-α shedding and upregulated the expression of TRAF3. Increased TRAF3 promoted TAK1 autophosphorylation, resulting in activated MAPKs pathway and cardiomyocyte apoptosis. ADAM17 acted as a positive regulator of cardiomyocyte apoptosis and cardiac remodeling and dysfunction induced by doxorubicin by upregulating TRAF3/TAK1/MAPKs signaling. Thus, targeting ADAM17/TRAF3/TAK1/MAPKs signaling holds a promising potential for treating doxorubicin-induced cardiotoxicity.
Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer
Authors: Labbé Maureen , Chang Manon , Saintpierre Benjamin , Letourneur Franck , de Beaurepaire Laurence , Véziers Joëlle , Deshayes Sophie , Cotinat Marine , Fonteneau Jean-François , Blanquart Christophe , Potiron Vincent , Supiot Stéphane , Fradin Delphine 
Published: October 2024

AbstractRadiotherapy represents a major curative treatment for prostate cancer (PCa), but some patients will develop radioresistance (RR) and relapse. The underlying mechanisms remain poorly understood, and miRNAs might be key players in the acquisition and maintenance of RR. Through their encapsulation in small extracellular vesicles (EVs), they can also be relevant biomarkers of radiation response. Using next-generation sequencing, we found that miR-200c-3p was downregulated in PCa RR cells and in their small EVs due to a gain of methylation on its promoter during RR acquisition. We next showed that its exogenous overexpression restores the radiosensitivity of RR cells by delaying DNA repair through the targeting of HP1α. Interestingly, we also observed downregulation of miR-200c-3p expression by DNA methylation in radiation-resistant lung and breast cancer cell lines. In summary, our study demonstrates that the downregulation of miR-200c-3p expression in PCa cells and in their small EVs could help distinguish radioresistant from sensitive tumor cells. This miRNA targets HP1α to delay DNA repair and promote cell death.
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution
Authors: Cong Boyi , Dong Xuan , Yang Zongheng , Yu Pin , Chai Yangyang , Liu Jiaqi , Zhang Meihan , Zang Yupeng , Kang Jingmin , Feng Yu , Liu Yi , Feng Weimin , Wang Dehe , Deng Wei , Li Fengdi , Song Zhiqi , Wang Ziqiao , Chen Xiaosu , Qin Hua , Yu Qinyi , Li Zhiqing , Liu Shuxun , Xu Xun , Zhong Nanshan , Ren Xianwen , Qin Chuan , Liu Longqi , Wang Jian , Cao Xuetao 
Published: October 2024

AbstractHow the lung achieves immune homeostasis after a pulmonary infection is not fully understood. Here, we analyzed the spatiotemporal changes in the lungs over a 2-week natural recovery from severe pneumonia in a Syrian hamster model of SARS-CoV-2 infection. We find that SARS-CoV-2 infects multiple cell types and causes massive cell death at the early stage, including alveolar macrophages. We identify a group of monocyte-derived Slamf9+ macrophages, which are induced after SARS-CoV-2 infection and resistant to impairment caused by SARS-CoV-2. Slamf9+ macrophages contain SARS-CoV-2, recruit and interact with Isg12+Cst7+ neutrophils to clear the viruses. After viral clearance, Slamf9+ macrophages differentiate into Trem2+ and Fbp1+ macrophages, contributing to inflammation resolution at the late stage, and finally replenish alveolar macrophages. These findings are validated in a SARS-CoV-2-infected hACE2 mouse model and confirmed with publicly available human autopsy single-cell RNA-seq data, demonstrating the potential role of Slamf9+ macrophages and their coordination with neutrophils in post-injury tissue repair and inflammation resolution.