bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using low‐cost, eco‐friendly natural and modified potato peels to effectively remove Mn(II) ions from aqueous solutions
Authors: Mutlu Canpolat , Altunkaynak Yalçın 
Published: October 2024

AbstractThe objective of this investigation is to look into the potential use of trash potato peels and processed potato peels as a solution for effectively removing Mn(II) ions extracted from aqueous solutions. The optimal working circumstances for removing Mn(II) ions from aqueous solution in PP are an initial concentration of 300 mg/L, an adsorbent dose of 0.3 g, a contact time (CT) of 100 min, and a solution pH of 6.08. The optimal working conditions for MPP were established to be an initial concentration of 300 mg/L, an adsorbent dosage of 0.15 g, a CT of 100 min, and a solution pH of 6.08. Studies were conducted at various temperatures to better understand the removal capabilities of adsorbent compounds. The removal abilities of Mn(II) ions for PP were determined to be 10.787, 13.698, and 16.556 mg/g at varied temperatures (25, 35, and 45°C), respectively. Under the same conditions, the removal capacity of MPP was determined to be 34.246, 45.045, and 51.813 mg/g. Further investigation of the adsorption kinetics revealed that the experimental results suited the pseudo‐second‐order model for both PP and MPP adsorbents. Thermodynamic analyses demonstrated that the endothermic process of Mn(II) metal ion adsorption onto the adsorbents occurred spontaneously. The study found that both PP and MPP were very efficient and ecologically friendly adsorbents for removing Mn(II) ions from aqueous solutions. Their demonstrated performance highlights their potential value in sustainable wastewater treatment applications, which accord with environmentally conscious behaviors.
Benchmarking the Performance of Lithium and Sodium‐Ion Batteries With Different Electrode and Electrolyte Materials
Authors: Paul Sandeep , Acharyya Debanjan , Punetha Deepak 
Published: October 2024

ABSTRACTSodium‐ion (Na‐ion) batteries are considered a promising alternative to lithium‐ion (Li‐ion) batteries due to the abundant availability of sodium, which helps mitigate supply chain risks associated with Li‐ion batteries. Many studies have focused on the design of Li‐ion batteries, exploring their energy, power, and cost aspects. However, there is still a lack of similar research conducted on Na‐ion batteries. A comparison of the cell voltage characteristics and rate capability of sodium and lithium‐ion batteries using different types of electrodes and electrolytes. For sodium‐ion batteries electrolytes used are NaPF6 and NaClO4 and electrodes used are NaCoO2, NaNiO2, NaFePO4, (Na3V2(PO4)3), graphite, hard carbon, sodium metal, and sodium titanate. For lithium‐ion batteries with LiPF6 and KOH electrolytes and electrodes as LiCoO2, NMC, LVP, Li2MnSiO4, graphite, silicon, lithium titanate (LTO), lithium metal. A thorough analysis of six important performance metrics is part of the investigation: Ragone plots, Electrolyte salt concentration versus spatial coordinate, electrolyte potential versus spatial coordinate, Cell voltage versus battery cell state of charge, Cell voltage versus time, and state variable versus time. Comparing operating voltage and rated capacity NMC and graphite is selected for lithium‐ion batteries as this combination provides operating voltage up to 4.2 V and a rated capacity of 275 Wh/kg, for sodium‐ion for NaCoO2 and hard carbon which has an operating voltage of 2.5–3.8 V and rated capacity around 200 Wh/kg and another combination of electrode as NaFePO4 and sodium metal with NaClO4 electrolyte has a maximum operating voltage of 2.8–3.8 V and rated capacity around 200 Wh/kg. This paper shows significant influence of electrolyte selection on battery performance. The Ragone plots demonstrate that LiPF6 electrolytes in lithium‐ion batteries and NaPF6 electrolytes in sodium‐ion batteries both exhibit superior specific energy densities compared to their KOH and NaClO4 counterparts, respectively. The work presented in this paper encourages researchers to select alternate electrolytes and electrodes for lithium‐ion and sodium‐ion batteries in order to obtain optimal device performance.
Analysis of the association between microbiota and flavor formation during Zizhong Dongjian fermentation process
Authors: Li Zhang , Wang Miao , Yang Zhirong 
Published: October 2024

AbstractZizhong Dongjian (ZZDJ) is one of the most famous and popular fermented vegetables in China. The aim of this study was to explore the microbial communities and volatile flavor compounds of ZZDJ during different fermentation periods, as well as to reveal the potential correlation between microbiota and flavor. A total of 84 volatile flavor compounds were detected in 0‐year to 3‐year ZZDJ samples. Hydrocarbons were the most abundant flavor compounds in 0‐year and 1‐year samples, while esters became the predominant flavor components in 2‐year and 3‐year samples. Furthermore, Loigolactobacillus, Pseudomonas, and Virgibacillus were most predominant bacteria during the fermentation process of ZZDJ. Interestingly, all the fungi identified were yeasts. Among them, Zygosaccharomyces and Symmetrospora dominated alternatively throughout the fermentation process of ZZDJ. Through analysis of relativity between flavor compounds and microorganism of ZZDJ, we found that Uncultured Pseudomonas sp., Virgibacillus sediminis, Zygosaccharomyces rouxii, and Symmetrospora marina might play important roles in flavor information of ZZDJ.
Associations of plasma omega‐6 and omega‐3 fatty acids with overall and 19 site‐specific cancers: A population‐based cohort study in UK Biobank
Authors: Zhang Yuchen , Sun Yitang , Song Suhang , Khankari Nikhil K. , Brenna J. Thomas , Shen Ye , Ye Kaixiong 
Published: October 2024

AbstractPrevious epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega‐3 and omega‐6 PUFAs with the incidence of overall and 19 site‐specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow‐up of 12.9 years, 29,838 participants were diagnosed with cancer. The plasma levels of omega‐3 and omega‐6 PUFAs were expressed as percentages of total fatty acids (omega‐3% and omega‐6%). In our main models, both omega‐6% and omega‐3% were inversely associated with overall cancer incidence (HR per SD = 0.98, 95% CI = 0.96–0.99; HR per SD = 0.99, 95% CI = 0.97–1.00; respectively). Of the 19 site‐specific cancers available, 14 were associated with omega‐6% and five with omega‐3%, all indicating inverse associations, with the exception that prostate cancer was positively associated with omega‐3% (HR per SD = 1.03, 95% CI = 1.01–1.05). Our population‐based cohort study in UK Biobank indicates small inverse associations of plasma omega‐6 and omega‐3 PUFAs with the incidence of overall and most site‐specific cancers, although there are notable exceptions, such as prostate cancer.
Quantile‐Based Test for Heterogeneous Treatment Effects
Authors: Chung EunYi , Olivares Mauricio 
Published: October 2024

ABSTRACTWe introduce a permutation test for heterogeneous treatment effects based on the quantile process. However, tests based on the quantile process often suffer from estimated nuisance parameters that jeopardize their validity, even in large samples. To overcome this problem, we use Khmaladze's martingale transformation. We show that the permutation test based on the transformed statistic controls size asymptotically. Numerical evidence asserts the good size and power performance of our test procedure compared to other popular quantile‐based tests. We discuss a fast implementation algorithm and illustrate our method using experimental data from a welfare reform.
Experimental colitis is comorbid with social interaction deficits and anxiety‐like behaviors in mice: mechanistic intuitions into neuroinflammation and Claudin 5 expression in the hippocampus
Authors: Ebrahimi‐Dehkordi Sepehr , Anjomshoa Maryam , Ghasemi Sorayya , Saghaei Elham , Nasiri‐Boroujeni Shakiba , Amini‐Khoei Hossein 
Published: October 2024

AbstractInflammatory bowel disease (IBD) is accompanied by psychiatric disorders, including Schizophrenic‐like manifestations. Although incompletely illustrated, intestinal mucosal membrane damage and blood‐brain barrier (BBB) penetrability may have significant roles in psychiatric symptoms of IBD. This study aimed to investigate role of the Claudin‐5 (CLDN5) (a regulator of the permeability of BBB) and neuroinflammatory response in the comorbid behavioral disorders in experimental colitis in mice. Acetic acid was used to induce colitis in mice. 7 days after induction of colitis, behaviors including social interaction and locomotor activity as well as anxiety‐like behaviors were evaluated. Then, the colon was extracted for gross and microscopic evaluations. The expression of CLDN5, TNF‐α, IL1β and IL23 was measured by RT‐PCR in the colon and hippocampus. Histopathologic evaluations demonstrated mucosal, submucosal, and crypt‐related damages in the colon. The negative and positive number of social interactions significantly increased in the colitis group. A considerable increase in locomotor activities (horizontal and vertical components) shown in the colitis group. Mice in colitis group spent less time in the central zone in the open field apparatus. Gene expressions of TNF‐α, IL1β, and IL23 increased and CLDN5 decreased in the colitis group. The barrier function of the intestine and brain would be impaired, partially at least, following colitis (as we observed decrease in CLDN5 gene expression). Furthermore, we found that beside inflammatory response in the colon, a neuro‐immune response triggered in the hippocampus following colitis. These alterations probably, mediated comorbid behavioral disorders in acetic acid‐induced colitis in mice.
Vanillic acid ameliorates diethyl phthalate and bisphenol S‐induced oxidative stress and neuroinflammation in the hippocampus of experimental rats
Authors: Eteng Ofem Effiom , Ugwor Emmanuel Ifeanyichukwu , James Adewale Segun , Moses Ceaser Antiya , Ogbonna Chukwuka Uzoamaka , Iwara Iwara Arikpo , Akamo Adio Jamiu , Akintunde Jacob Kehinde , Blessing Olokode Ayomide , Tola Yinus Mujeeb , Eru Eru Mba , Igiri Anozeng Oyono 
Published: October 2024

AbstractLong‐term adverse effects on human health are caused by exogenous compounds that alter the functions of biological systems, especially neuroendocrine disruptors like diethyl phthalate (DEP) and bisphenol S (BPS). Although vanillic acid (VA) has pertinent neuropharmacological characteristics, its effect against DEP + BPS‐induced neurotoxicity has not been explored. This study proposed that VA may offer protection against the neurotoxicity caused by DEP + BPS. Thirty male Wistar rats were randomly distributed across five groups: a control group receiving DMSO, a group exposed to a mixture of BPS and DEP, two BPS + DEP‐exposed groups treated with VA at doses of 25 mg/kg or 50 mg/kg, and a nonexposed group treated with 50 mg VA/kg. After 21 days, the hippocampal tissues were processed for biochemical analyses. Our results indicate that exposure to DEP + BPS upregulated neurosignaling mediators (NTPDase, ADA, MAO‐A, and Ca2+), inhibited others (AChE and Ca2+/Mg2+‐ATPase), decreased hippocampus antioxidants (GSH, GPx, CAT, and SOD), and elevated markers of oxidative stress/damage (NO, H2O2, MDA, and AOPP). AR, BAX, TNF‐α, BAK1, and IL‐1β expressions were upregulated, while IL‐10 and BDNF expressions were downregulated. NF‐κB and caspase‐3/9 pathways were also upregulated. Co‐treatment with vanillic acid remarkably precluded these neurotoxic outcomes by improving neurosignaling, augmenting antioxidant status, abrogating oxidative damage, inflammation (TNF‐α, IL‐1β), and apoptosis (BAX, BAK1, caspase‐3/9). Vanillic acid also restored IL‐10 and BDNF levels, thereby exhibiting neuroprotective effects, corroborated by histological examinations. We posit vanillic acid as a safe and effective therapeutic agent against neurotoxicity occasioned by exposure to neuroendocrine disruptors.
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage
Authors: Soliman Maher M. , Tohamy Adel F. , Prince Abdelbary M. , Hussien Ahmed M. , Nashed Marsail S. 
Published: October 2024

AbstractFenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It is very effective, has a wide range of activities, and works quickly. Internationally, it is commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount of data indicates a substantial link between Fenpropathrin and adverse effects on nontarget species, including liver toxicity, kidney toxicity, nerve damage, and reproductive toxicity. Oxidative stress plays a vital role in the toxicity of fenpropathrin, in addition to its mechanical mechanism. This study offers a thorough examination of the harmful effects of Fenpropathrin on oxidative and mitochondrial processes, as well as the signaling pathways involved in these effects. The significant impact of oxidative stress emphasizes the toxicity of Fenpropathrin.
Lead Independent Directors and Real Earnings Management
Authors: Bryan David B. , Mason Terry W. , West Ashley N. 
Published: October 2024

ABSTRACTExisting studies suggest that lead independent directors (LIDs) improve corporate governance, audit quality, and some aspects of financial reporting quality. We extend this line of literature by investigating whether there is a relation between firms with an LID and real earnings management (REM). In addition, we investigate this relationship further by looking at the impact of an audit committee, specifically, firms with an LID that either does or does not serve on the audit committee. Using four measures of REM, we find that firms with an LID are associated with less REM. Importantly, we only find consistent evidence of this association for firms with an LID who serve on the audit committee. Our findings, considered in conjunction with the results from prior literature, suggest that LIDs play a role in broadly improving financial reporting quality, especially when they are part of the audit committee.
The LTAR Cropland Common Experiment at the Kellogg Biological Station
Authors: Robertson G. Philip , Wilke Brook , Ulbrich Tayler , Haddad Nick M. , Hamilton Stephen K. , Baas Dean G. , Basso Bruno , Blesh Jennifer , Boring Timothy J. , Campbell Laura , Cassida Kimberly A. , Charles Christine , Chen Jiquan , Doll Julie E. , Guo Tian , Kravchenko Alexandra N , Landis Douglas A. , Marquart‐Pyatt Sandra T. , Singh Maninder P. , Sprunger Christine D. , Stegink Jason 
Published: October 2024

AbstractThe Kellogg Biological Station Long‐term Agroecosystem Research site (KBS LTAR) joined the national LTAR network in 2015 to represent a northeast portion of the North Central Region, extending across 76,000 km2 of southern Michigan and northern Indiana. Regional cropping systems are dominated by corn (Zea mays)–soybean (Glycine max) rotations managed with conventional tillage, industry‐average rates of fertilizer and pesticide inputs uniformly applied, few cover crops, and little animal integration. In 2020, KBS LTAR initiated the Aspirational Cropping System Experiment as part of the LTAR Common Experiment, a co‐production model wherein stakeholders and researchers collaborate to advance transformative change in agriculture. The Aspirational (ASP) cropping system treatment, designed by a team of agronomists, farmers, scientists, and other stakeholders, is a five‐crop rotation of corn, soybean, winter wheat (Triticum aestivum), winter canola (Brassicus napus), and a diverse forage mix. All phases are managed with continuous no‐till, variable rate fertilizer inputs, and integrated pest management to provide benefits related to economic returns, water quality, greenhouse gas mitigation, soil health, biodiversity, and social well‐being. Cover crops follow corn and winter wheat, with fall‐planted crops in the rotation providing winter cover in other years. The experiment is replicated with all rotation phases at both the plot and field scales and with perennial prairie strips in consistently low‐producing areas of ASP fields. The prevailing practice (or Business as usual [BAU]) treatment mirrors regional prevailing practices as revealed by farmer surveys. Stakeholders and researchers evaluate the success of the ASP and BAU systems annually and implement management changes on a 5‐year cycle.
CD19‐targeting chimeric antigen receptor T‐cell therapy is safe and effective for intra‐cardiac B cell non‐Hodgkin lymphoma
Authors: Chen Daniel H. , O'Reilly Maeve , Cheok Kathleen P. , Low Ryan , Puranik Rajesh , Clark Samuel , Walker John Malcolm , Manisty Charlotte , Ghosh Arjun K. , Roddie Claire 
Published: October 2024

AbstractIntroductionChimeric antigen receptor T‐cell (CAR‐T) therapy is highly effective in B‐cell blood cancers, but there is limited data on its safety and efficacy in intra‐cardiac lymphoma, due to the potential risks of cardiotoxicity and pseudo‐progression.DiscussionWe discuss four high‐risk cases that were managed with a multi‐disciplinary approach, including baseline cardiac risk assessment and surveillance with multimodal cardiac imaging and serum cardiac biomarkers, elective supportive care in the intensive care unit, and early treatment of cytokine release syndrome.ConclusionCAR‐T therapy can be effective and safe in the treatment of B‐cell blood cancers with intra‐cardiac disease.
Identification of patients on chronic prescription opioids at risk for opioid use disorder using pharmacy claims data
Authors: Jantzen Aleesha , Hall Scott Thomas , Lai Benjamin , Cunningham Julie L. , Odell Laura 
Published: October 2024

AbstractUsing pharmacy claims data from a single commercial health plan to identify opportunities for opioid use disorder (OUD) focused screening and interventions communicated via targeted prescriber messaging. Participants included members ≥18 years using more than 90 morphine milligram equivalents (MMED) daily based on all opioid claims, had >1 paid claim for an opioid product, and had ≥90 days of total opioid therapy. Members were excluded with ≥1 claims for an oral chemotherapy agent (except methotrexate). Intervention was completed with a secure communication to the primary outpatient opioid prescriber that included resources for diagnosis, treatment, and best practices for opioid prescribing. The main outcome measure was any documented change to opioid use following the intervention. Seven hundred forty‐five members were identified; a subset (n = 20) was further assessed, and all had identified OUD risk factors; providers were subsequently sent a communication. Sixteen providers acknowledged receipt and 11 patients (55%) had at least one documented intervention following communication receipt. Provision of targeted, evidence‐based recommendations to providers for patients identified to be at risk of OUD from pharmacy claims data can result in increased recognition and intervention. Future efforts to explore feasibility of provider education detailing efforts and continued evaluation of efficacy are needed.
Patient‐Initiated Communication After Parotidectomy
Authors: Prince Andrew D.P. , Oslin Kimberly , Forner David , Smith Josh D. , Hershey Emma , Chionis Lisa , Allevato Michael , Prince Mark E.P. , Chinn Steven B. 
Published: October 2024

ObjectivesWe sought to study the incidence of patient‐initiated communication after parotidectomy, identify patient and surgical factors associated with patient‐initiated communication, and evaluate trends and possible areas for improvement.MethodsA retrospective cohort study of patients who underwent parotidectomy without combined procedures from 2018 to 2022 in a single tertiary‐care institution was performed. We reviewed all patient communications documented within the electronic medical record within 30 days of discharge. We categorized patient communications as requiring an action by the surgeon, instruction by support staff, or reassurance.ResultsA total of 363 patients were included. Most patients were women (55.4%), Caucasian (78.8%), and had an average age of 56 years ± 16. We found 123 (33.9%) patients initiated postoperative communications. Swelling (47.2%) was the most common concern followed by wound concerns (15.4%). Switching from planned inpatient to outpatient surgery increased (OR = 2.635; 95% CI = 1.200–6.146, p = 0.026) propensity for postoperative communication. We found 31 (25.2%) postoperative communications required an action by the surgeon, 40 (32.5%) required instruction by the support staff, and the other 52 (42.3%) required reassurance or clarification. Multivariate analysis showed swelling (OR = 6.5, CI = 2.2–19, p < 0.001), male sex (OR = 3.27, CI = 1.127–9.459, p = 0.029), previous smoking (OR = 3.468, CI = 1.181–10.185, p = 0.024), and cancer (OR = 6.862, CI = 1.757–26.804, p = 0.006) were predictive of requiring an action by the surgeon.ConclusionsThis is the first study to evaluate patient‐initiated communication after parotidectomy and found it occurred 33.4% of the time. We found significant opportunities to improve perioperative care, enhance patient satisfaction, and reduce the overall burden on medical personnel.Level of Evidence4 Laryngoscope, 135:1105–1112, 2025
Evaluating the Antibacterial and Anti‐Biofilm Properties of Chitosan Nanoemulsion Containing Euphorbia hebecarpa Plant Extract Against Escherichia coli and Staphylococcus aureus
Authors: Ameen Fuad , Almishrif Karimah , Al‐Masri Abeer A. , Alyahya Sami , Alfalih Abdullah 
Published: October 2024

ABSTRACTThe use of nanoparticles as drug‐carrying systems in medicine has received much attention, and on the other hand, the use of plants with medicinal properties has advantages over synthetic drugs. This study aims to improve the antibacterial and anti‐biofilm properties of Euphorbia hebecarpa plant extract using chitosan nanoparticles. Extraction were performed using the modified maceration and methanol solvent. The agar disc diffusion method was carried out to investigate the antimicrobial effects and MIC at an optical density (OD) of 630 nm. The anti‐biofilm agent's influence was measured at OD 570 nm, and the metabolic activity of bacteria in the damaged biofilm was determined using triphenyl tetrazolium chloride (TTC) staining. The nanoparticles were obtained by following the ionic gelation method and its characteristics were evaluated. Chitosan nanoparticles loaded with plant extract were found to be spherical shape with hydrodynamic diameter of 142 nm, a polydispersity index (PDI) of 0.184, a zeta potential of +28.6 mV. It was determined that the loading capacity (% LC) and encapsulation efficiency (% EE) percentages were 33% and 40%, respectively. The diameter of the inhibition zone in the agar disc diffusion test for both bacteria using nanoparticles loaded with the extract increased compared with control groups. Also, at a concentration of 4 mg/mL of loaded nanoparticles, 49.33% of Escherichia coli biofilm and 62.7% of Staphylococcus aureus biofilm were destroyed. The data obtained from the tests performed in this study show that the use of Euphorbia plant extract in the form of chitosan nanoparticles can have more antimicrobial and anti‐biofilm effects.