bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of lactic acid bacteria on stereoselective degradation of theta‐cypermethrin
Authors: Shi Kaiwei , Chen Zenglong , Liu Fengmao , Li Li , Yuan Longfei 
Published: January 2018

AbstractThe purpose of this study was to investigate the influence of four kinds of Lactic acid bacteria (LAB) on stereoselective degradation of theta‐cypermethrin (CYP), including Lactobacillus plantarum, Lactobacillus casei, Lactobacillus delbrueckii, and Streptococcus thermophilus. An effective analytical method for (±)‐theta‐CYP in medium was developed by high‐performance liquid chromatography with cellulose tris‐(3,5‐dimethylphenylcarbamate) chiral stationary phase. theta‐Cypermethrin was spiked to LAB medium with different inoculation rates and sampled at 0, 2, 8, 24, 36, 48, 72, 120, 168, and 240 hours. The results showed that LAB influenced the half‐lives and enantiomer fractions of theta‐CYP enantiomers, which lead a closer degradation rate between the 2 stereoisomers, and no obvious difference was found among 4 LABs. Besides, the stereoselective degradation of theta‐CYP was closely related to pH. The lower the pH (pH of 3, 5, 7, and 9), the lower the enantiomer fraction (from 4.88 to 6.69). At pH of 3, 7, and 9, significant differences of half‐lives between enantiomers were observed. (−)‐theta‐Cypermethrin decreased faster than (+)‐theta‐CYP under pH of 3, while opposite results were indicated under pH of 7 and 9. Moreover, the acidic condition contributed to the higher chiral configuration stability of (±)‐theta‐CYP. (+)‐Enantiomer was influenced by pH in a greater degree than (−)‐enantiomer.
Expanding Covalent Attachment Sites of Nonnative Chromophores to Encompass the C‐Terminal Hydrophilic Domain in Biohybrid Light‐Harvesting Architectures
Authors: Hood Don , Sahin Tuba , Parkes‐Loach Pamela S. , Jiao Jieying , Harris Michelle A. , Dilbeck Preston , Niedzwiedzki Dariusz M. , Kirmaier Christine , Loach Paul A. , Bocian David F. , Lindsey Jonathan S. , Holten Dewey 
Published: January 2018

AbstractIncreasing the solar spectral coverage of native photosynthetic antennas can be achieved using biohybrid light‐harvesting (LH) structures comprised of native‐like bacterial photosynthetic peptides and synthetic bacteriochlorins with strong near‐infrared absorption. Four such biohybrids have been prepared wherein synthetic maleimido‐bearing bacteriochlorin BC1‐mal is covalently attached to a Cys residue substituted at either the +1, +5 or +11 position (relative to His‐0) of the 48‐residue β‐peptide of Rb. sphaeroides LH1. In addition, a β‐peptide with Phe substituted for Tyr at the +4 position along with +1Cys was used to examine possible quenching of the excited BC1 by the Tyr. The β‐peptide analogs, as well as their peptide‐BC1 conjugates when combined with native α‐peptide, and bacteriochlorophyll a (BChl a) self‐assemble to form αβ‐dyads and therefrom LH1‐type cyclic (αβ)n oligomers. Static and time‐resolved optical studies show that all of the oligomeric assemblies transfer excitation energy from the appended BC1 to the BChl a array (B875) with an average efficiency of 85 %.
Piezoelectric Energy Harvesting Systems—Essentials to Successful Developments
Authors: Uchino Kenji 
Published: January 2018

AbstractIn recent years, industrial and academic research units have focused on harvesting energy from mechanical vibrations using piezoelectric transducers. These efforts have provided research guidelines and have brought to light the problems and limitations of piezoelectric systems. There are three major phases associated with piezoelectric energy harvesting: (i) mechanical–mechanical energy transfer, including mechanical stability of the piezoelectric transducer under large stresses, and mechanical impedance matching, (ii) mechanical–electrical energy transduction, relating to the electromechanical coupling factor in the composite transducer structure, and (iii) electrical–electrical energy transfer, including electrical impedance matching, such as a direct current (DC/DC) conversion to transfer the energy to a rechargeable battery. This Review starts from the historical background of piezoelectric energy harvesting, followed by several misconceptions by current researchers. The main part deals with step‐by‐step detailed energy flow analysis energy harvesting systems with lead zirconate titanate (PZT)‐based devices to provide comprehensive strategies on how to improve the efficiency of the harvesting system.
Ternary‐Phase Li4Ti5O12/TiO2 Nanosheet Composite for High Rate Lithium‐Ion Batteries
Authors: Zhuang Jingxiang , Wang Ziye , Zhang Jiangtao , Lu Gang , Kang Xiaohong , Cheng Zhiming 
Published: January 2018

AbstractA ternary‐phase Li4Ti5O12/TiO2 (LTO/TiO2) nanosheet composite is successfully synthesized by a one‐pot hydrothermal method followed by two‐step annealing ways. It exhibits high specific capacities of 170 mAh g−1, 154 mAh g−1, 138.5 mAh g−1, and 123.9 mAh g−1 at 1 C, 10 C, 30 C and 50 C, respectively. After 3000 cycles at 20 C, over 89.2 % original specific capacity retention is maintained with approximately 100 % columbic efficiency. The excellent rate performance and cycling stability are attributed to the high crystallinity, the thin nanosheets, the high surface area, and an appropriate amount of nanostructured TiO2 seeds dispersed in the Li4Ti5O12 (LTO) matrix for the final products.
Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors
Authors: Manukyan Arkadi , Kowalczyk Izabela , Melhuish Tiffany A. , Lemiesz Agata , Wotton David 
Published: January 2018

AbstractMyt1 and Myt1l (Myelin transcription factor 1, and Myt1‐like) are members of a small family of closely related zinc finger transcription factors, characterized by two clusters of C2HC zinc fingers. Both are widely expressed during early embryogenesis, but are largely restricted to expression within the brain in the adult. Myt1l, as part of a three transcription factor mix, can reprogram fibroblasts to neurons and plays a role in maintaining neuronal identity. Previous analyses have indicated roles in both transcriptional activation and repression and suggested that Myt1 and Myt1l may have opposing functions in gene expression. We show that when targeted to DNA via multiple copies of the consensus Myt1/Myt1l binding site Myt1 represses transcription, whereas Myt1l activates. By targeting via a heterologous DNA binding domain we mapped an activation function in Myt1l to an amino‐terminal region that is poorly conserved in Myt1. However, genome wide analyses of the effects of Myt1 and Myt1l expression in a glioblastoma cell line suggest that the two proteins have largely similar effects on endogenous gene expression. Transcriptional repression is likely mediated by binding to DNA via the known consensus site, whereas this site is not associated with the transcriptional start sites of genes with higher expression in the presence of Myt1 or Myt1l. This work suggests that these two proteins function similarly, despite differences observed in analyses based on synthetic reporter constructs.
A Comparison of Femoral Lengthening Methods Favors the Magnetic Internal Lengthening Nail When Compared with Lengthening Over a Nail
Authors: Fragomen Austin T. , Kurtz Anton M. , Barclay Jonathan R. , Nguyen Joseph , Rozbruch S. Robert 
Published: January 2018

Background Bone lengthening with an internal lengthening nail (ILN) avoids the need for external fixation and requires one less surgical procedure than lengthening over a nail (LON). However, LON has been shown to be superior to femoral internal lengthening using a mechanical nail. The magnetic ILN, a remote-controlled and magnet-driven device, may have overcome the weaknesses of earlier internal lengthening technology and may be superior to LON. Questions/Purposes (1) Is the magnetic ILN more accurate than LON for femoral lengthening? (2) Does the magnetic ILN demonstrate more precise distraction rate control than LON? (3) Does the magnetic ILN result in faster regenerate site healing, with more robust callus, than LON? (4) Does the magnetic ILN result in fewer complications, including impediments to knee motion, than LON? Methods We conducted a retrospective comparison of the records and radiographs of 21 consecutive patients with 22 femoral lengthenings using LONs and 35 consecutive patients with 40 femoral lengthenings using remote-controlled magnetic ILNs. Primary outcomes measured included accuracy, distraction rate precision, time to bony union, final knee range of motion, regenerate quality, and complications. The minimum follow-up times for the LON and ILN cohorts were 13 and 21 months, respectively. Results Patients treated with ILN had a lower post-treatment residual limb-length discrepancy (0.3 mm) than those treated with LON (3.6 mm). The rate of distraction was closer to the goal of 1 mm/day and more tightly controlled for the ILN cohort (1 mm/day) than that for the LON group (0.8 mm/day; SD, 0.2). Regenerate quality was not significantly different between the cohorts. Bone healing index for ILN was not statistically significant. Time to union was shorter in the ILN group (3.3 months) than that in the LON group (4.5 months). A lower percentage of patients experienced a complication in the ILN group (18%) than in the LON group (45%). Knee flexion at the end of distraction was greater for ILN patients (105°) than that for LON patients (88.8°), but this difference was no longer observed after 1 year. Conclusions Femoral lengthening with magnetic ILN was more accurate than with LON. The magnetic ILN comports the additional advantage of greater precision with distraction rate control and fewer complications. Both techniques afford reliable healing and do not significantly affect knee motion at the final follow-up. The magnetic ILN method showed no superiority in regenerate quality and healing rate.
Cancer risk incidence from hypothetical accident of VVER-1000 nuclear power plant based on BEIR VII model
Authors: Hosseini Aghdam Mir Rashid , Baghani Hamid Reza , Hosseini Aghdam Afsaneh 
Published: January 2018

AbstractBackgroundSafety is a mandatory issue during the operation of a nuclear power plant. A nuclear reactor can have some atmospheric dispersion due to any errors in the safety system.PurposeThe aim of this study is to estimate the cancer risk incidence for different body organs due to accidentally released radionuclides from Bushehr Nuclear Power Plant (BNPP).Materials and methodsThe assumed hypothesis was atmospheric dispersion of radionuclide into the environment due to the safety failure of BNPP. Total effective dose equivalent (TEDE) from radionuclide diffusion in the medium was calculated using HOTSPOT code at two different wind speeds. Finally, the risk of cancer incidence for different organs of male and female sex has been estimated by Biologic Effects of Ionizing Radiation (BEIR) VII model.ResultsThe results showed that with increasing the exposure age and attained age, the risk of cancer incidence for different organs is decreased. The value of TEDE was increased at lower wind speed. The most probable organ for cancer incidence at different levels of TEDE in male and female sex was colon and bladder, respectively. On the other hand, prostate and uterus had the lowest radiation sensitivity and cancer risk incidence in male and female sex, respectively. Increasing the wind speed reduces the risk of cancer incidence for all of organs understudy.ConclusionBased on the obtained results, it can be concluded that the younger persons are more subject to the cancer risk incidence because of both the intrinsically greater radio-sensitivity of their organs and their longer remaining life expectancy during which a cancer may develop. The overall risk of cancer incidence as well as the site specific solid cancer incidence were highly dependent to the sex of exposed person, so that the female sex was more exposed to the cancer risk incidence at all of the irradiation levels understudy.
Microfluidic actuators based on temperature-responsive hydrogels
Authors: D'Eramo Loïc , Chollet Benjamin , Leman Marie , Martwong Ekkachai , Li Mengxing , Geisler Hubert , Dupire Jules , Kerdraon Margaux , Vergne Clémence , Monti Fabrice , Tran Yvette , Tabeling Patrick 
Published: January 2018

AbstractThe concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive, but limitations, in terms of spatial resolution, speed, reliability and integration, have hindered its development during the past two decades. By patterning and grafting poly(N-isopropylacrylamide) PNIPAM hydrogel films on plane substrates with a 2 μm horizontal resolution and closing the system afterward, we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now. In this paper, we demonstrate, for the first time with this technology, devices with up to 7800 actuated micro-cages that sequester and release solutes, along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s, respectively. Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test (NAAT) for the Human Synaptojanin 1 gene, which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease. The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs, hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics, that are, pressure actuated polydimethylsiloxane (PDMS) valves and droplets.
Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays
Authors: Zhang Song , Song Yilin , Wang Mixia , Xiao Guihua , Gao Fei , Li Ziyue , Tao Guoxian , Zhuang Ping , Yue Feng , Chan Piu , Cai Xinxia 
Published: January 2018

AbstractParkinson’s disease (PD) is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons. The precise mechanisms are still unknown. Since the neuronal communications are inherently electrical and chemical in nature, dual-mode detection of PD-related neuroelectrical and neurochemical information is essential for PD research. Subthalamic nucleus (STN) high-frequency stimulation (HFS) can improve most symptoms of PD patients and decrease the dosage of antiparkinsonian drugs. The mechanism of STN-HFS for PD still remains elusive. In this study, a silicon-based dual-mode microelectrode array (MEA) probe was designed and fabricated, and systematic dual-mode detection methods were established. The recording sites were modified using Pt nanoparticles and Nafion to improve the signal-to-noise (SNR) ratio. To evaluate its applicability to PD research, in vivo electrophysiological and electrochemical detection was performed in normal and hemiparkinsonian models, respectively. Through comparison of the dual-mode signals, we demonstrated the following in a PD monkey: (1) the maximum dopamine concentration in the striatum decreased by 90%; (2) the spike firing frequency increased significantly, especially in the region of the cortex; (3) the spectrogram analysis showed that much power existed in the 0–10 Hz frequency band; and (4) following repeated subthalamic nucleus high-frequency stimulation trials, the level of DA in the striatum increased by 16.5 μM, which led to a better elucidation of the mechanism of HFS. The dual-mode MEA probe was demonstrated to be an effective tool for the study of neurological disorders.
Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1
Authors: Wang Jinkun , Gan Yan , Han Pengcheng , Yin Junxiang , Liu Qingwei , Ghanian Soha , Gao Feng , Gong Guanghui , Tang Zhiwei 
Published: January 2018

AbstractThe chemokine fractalkine (CX3CL1) and its receptor CX3CR1 play a fundamental role in the pathophysiology of stroke. Previous studies have focused on a paracrine interaction between neurons that produce fractalkine and microglia that express CX3CR1 receptors in the central nervous system. Recent findings have demonstrated the functional expression of CX3CR1 receptors by hippocampal neurons, suggesting their involvement in neuroprotective and neurodegenerative actions. To elucidate the roles of neuronal CX3CR1 in neurodegeneration induced by ischemic stroke, a mouse model of permanent middle cerebral artery occlusion (pMCAO) was employed. In the pMCAO mice, increased CX3CR1 levels, apoptosis-associated morphological changes, and Caspase 3-positive neuronal cells were observed in the striatum and in the hippocampus 24 hours after occlusion. Upregulation of CX3CR1 in ischemic neurons is associated with neuronal apoptotic cell death. In contrast, ischemia-induced apoptotic neuronal cell death was decreased in CX3CR1 deficient mice. Cultured primary hippocampal neurons obtained from CX3CR1 deficient mice were more resistant to glutamate-induced excitotoxicity by blocking calcium influx than those from wild-type mice. For the first time, we reported that neuronal CXCR1 mediates neuronal apoptotic cell death in ischemia. Our results suggest that modulating CXCR1 activity offers a novel therapeutic strategy for stroke.
Carrier Dynamics and Electro-Optical Characterization of High-Performance GaN/InGaN Core-Shell Nanowire Light-Emitting Diodes
Authors: Nami Mohsen , Stricklin Isaac E. , DaVico Kenneth M. , Mishkat-Ul-Masabih Saadat , Rishinaramangalam Ashwin K. , Brueck S. R. J. , Brener Igal , Feezell Daniel F. 
Published: January 2018

AbstractIn this work, we demonstrate high-performance electrically injected GaN/InGaN core-shell nanowire-based LEDs grown using selective-area epitaxy and characterize their electro-optical properties. To assess the quality of the quantum wells, we measure the internal quantum efficiency (IQE) using conventional low temperature/room temperature integrated photoluminescence. The quantum wells show a peak IQE of 62%, which is among the highest reported values for nanostructure-based LEDs. Time-resolved photoluminescence (TRPL) is also used to study the carrier dynamics and response times of the LEDs. TRPL measurements yield carrier lifetimes in the range of 1–2 ns at high excitation powers. To examine the electrical performance of the LEDs, current density–voltage (J-V) and light-current density-voltage (L-J-V) characteristics are measured. We also estimate the peak external quantum efficiency (EQE) to be 8.3% from a single side of the chip with no packaging. The LEDs have a turn-on voltage of 2.9 V and low series resistance. Based on FDTD simulations, the LEDs exhibit a relatively directional far-field emission pattern in the range of $$\pm $$

±

15°. This work demonstrates that it is feasible for electrically injected nanowire-based LEDs to achieve the performance levels needed for a variety of optical device applications.
Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial–mesenchymal transition in aged rats
Authors: Huang Dong-Yan , Zheng Cheng-Cheng , Pan Qi , Wu Shuang-Shuang , Su Xin , Li Lei , Wu Jian-Hui , Sun Zu-Yue 
Published: January 2018

AbstractBisphenol A (BPA) is a well-known endocrine disruptor compound reported to have prostate toxicity. This study aimed to assess the effect of BPA on the proliferation of dorsolateral prostate (DLP) and the expression of epithelial–mesenchymal transition (EMT)-related genes in aged rats. Male aged SD rats were treated with BPA (10.0, 30.0, and 90.0 µg/kg i.g., daily) or vehicle (i.g., daily) for 3 months. Treatment with BPA resulted in increased the expression of PCNA, DLP weight and DLP epithelial height compared with the control group (P < 0.01); such effects were more obvious at higher BPA doses. 90 µg/kg BPA significantly increased the estrogen to androgen ratio (P < 0.05). The EMT chip showed the BPA induced upregulation of vimentin, Snail, Twist1, and transforming growth factor beta 1, as well as the downregulation of E-cadherin in the DLP. Immunohistochemical data showed that the expression of vimentin, estrogen receptor subtypes, and androgen receptor increased and the expression of E-cadherin decreased in 30 and 90 µg/kg BPA groups. It was concluded that environmental exposure to low doses of BPA might promote the proliferation of DLP in aged rats by increasing the estrogen to androgen ratio and inducing EMT.
Lateral and Basal Amygdala Account for Opposite Behavioral Responses during the Long-Term Expression of Fearful Memories
Authors: Manassero Eugenio , Renna Annamaria , Milano Luisella , Sacchetti Benedetto 
Published: January 2018

AbstractMemories of fearful events can be maintained throughout the lifetime of animals. Here we showed that lesions of the lateral nucleus (LA) performed shortly after training impaired the retention of long-term memories, assessed by the concomitant measurement of two dissociable defensive responses, freezing and avoidance in rats. Strikingly, when LA lesions were performed four weeks after training, rats did not show freezing to a learned threat stimulus, but they were able to direct their responses away from it. Similar results were found when the central nucleus (CeA) was lesioned four weeks after training, whereas lesions of the basal nucleus (BA) suppressed avoidance without affecting freezing. LA and BA receive parallel inputs from the auditory cortex, and optogenetic inhibition of these terminals hampered both freezing and avoidance. We therefore propose that, at variance with the traditional serial flow of information model, long-term fearful memories recruit two parallel circuits in the amygdala, one relying on the LA-to-CeA pathway and the other relying solely on BA, which operate independently and mediate distinct defensive responses.