bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’éphémère consécration de Juana, mon aimée, roman de Harry Bernard
Authors: Gaudreau Guy , Tremblay Micheline 
Published: May 2016

Cet article retrace la trajectoire du roman Juana, mon aimée de Harry Bernard, de sa première version parue à la fin de l’automne 1930 jusqu’à sa consécration concrétisée par l’obtention d’un prix David en septembre 1932. Cette consécration fut néanmoins bien éphémère puisque l’oeuvre est aujourd’hui absente de l’histoire littéraire. Grâce à une riche correspondance, conservée en grande partie dans le Fonds Harry-Bernard, et au dépouillement minutieux des divers comptes rendus, recensions et articles publiés dans les journaux et revues, l’article analyse le rôle de l’auteur et met en lumière les contributions décisives d’Alfred DesRochers, de Claude-Henri Grignon et d’Albert Pelletier dans le sort réservé au roman. L’examen de la réception critique permet également de montrer l’importance des débats privés, des réseaux d’amitié et des discussions de salon tout autant que le poids inégal des recensions dans la trajectoire de l’ouvrage. Il appert que deux discours dominants ont été tenus à propos de l’oeuvre : le premier, favorable, de Grignon, qui conduisit au prix David, et le second, très sévère, de Pelletier, qui a contribué, selon nous, à la faire sombrer dans l’oubli.
Future changes in regional precipitation simulated by a half‐degree coupled climate model: Sensitivity to horizontal resolution
Authors: Shields Christine A. , Kiehl Jeffrey T. , Meehl Gerald A. 
Published: May 2016

AbstractThe global fully coupled half‐degree Community Climate System Model Version 4 (CCSM4) was integrated for a suite of climate change ensemble simulations including five historical runs, five Representative Concentration Pathway 8.5 [RCP8.5) runs, and a long Pre‐Industrial control run. This study focuses on precipitation at regional scales and its sensitivity to horizontal resolution. The half‐degree historical CCSM4 simulations are compared to observations, where relevant, and to the standard 1° CCSM4. Both the half‐degree and 1° resolutions are coupled to a nominal 1° ocean. North American and South Asian/Indian monsoon regimes are highlighted because these regimes demonstrate improvements due to higher resolution, primarily because of better‐resolved topography. Agriculturally sensitive areas are analyzed and include Southwest, Central, and Southeast U.S., Southern Europe, and Australia. Both mean and extreme precipitation is discussed for convective and large‐scale precipitation processes. Convective precipitation tends to decrease with increasing resolution and large‐scale precipitation tends to increase. Improvements for the half‐degree agricultural regions can be found for mean and extreme precipitation in the Southeast U.S., Southern Europe, and Australian regions. Climate change responses differ between the model resolutions for the U.S. Southwest/Central regions and are seasonally dependent in the Southeast and Australian regions. Both resolutions project a clear drying signal across Southern Europe due to increased greenhouse warming. Differences between resolutions tied to the representation of convective and large‐scale precipitation play an important role in the character of the climate change and depend on regional influences.
Assimilation of gridded terrestrial water storage observations from GRACE into a land surface model
Authors: Girotto Manuela , De Lannoy Gabriëlle J. M. , Reichle Rolf H. , Rodell Matthew 
Published: May 2016

AbstractObservations of terrestrial water storage (TWS) from the Gravity Recovery and Climate Experiment (GRACE) satellite mission have a coarse resolution in time (monthly) and space (roughly 150,000 km2 at midlatitudes) and vertically integrate all water storage components over land, including soil moisture and groundwater. Data assimilation can be used to horizontally downscale and vertically partition GRACE‐TWS observations. This work proposes a variant of existing ensemble‐based GRACE‐TWS data assimilation schemes. The new algorithm differs in how the analysis increments are computed and applied. Existing schemes correlate the uncertainty in the modeled monthly TWS estimates with errors in the soil moisture profile state variables at a single instant in the month and then apply the increment either at the end of the month or gradually throughout the month. The proposed new scheme first computes increments for each day of the month and then applies the average of those increments at the beginning of the month. The new scheme therefore better reflects submonthly variations in TWS errors. The new and existing schemes are investigated here using gridded GRACE‐TWS observations. The assimilation results are validated at the monthly time scale, using in situ measurements of groundwater depth and soil moisture across the U.S. The new assimilation scheme yields improved (although not in a statistically significant sense) skill metrics for groundwater compared to the open‐loop (no assimilation) simulations and compared to the existing assimilation schemes. A smaller impact is seen for surface and root‐zone soil moisture, which have a shorter memory and receive smaller increments from TWS assimilation than groundwater. These results motivate future efforts to combine GRACE‐TWS observations with observations that are more sensitive to surface soil moisture, such as L‐band brightness temperature observations from Soil Moisture Ocean Salinity (SMOS) or Soil Moisture Active Passive (SMAP). Finally, we demonstrate that the scaling parameters that are applied to the GRACE observations prior to assimilation should be consistent with the land surface model that is used within the assimilation system.
Cost‐Effectiveness of Cardiovascular Screening in Patients With Rheumatoid Arthritis
Authors: Kievit Wietske , Maurits Jake S. F. , Arts Elke E. , van Riel Piet L. C. M. , Fransen Jaap , Popa Calin D. 
Published: May 2016

ObjectiveEarly detection and preemptive treatment of patients at risk is of great importance in reducing the excess risk of cardiovascular (CV) disease in rheumatoid arthritis (RA). However, it is unclear how much screening is cost‐effective in RA. The objective is to assess whether CV screening in RA proves to be cost‐effective from a medical perspective, using different scenarios based on different guidelines.MethodsA Markov chain model was used with a time horizon of 10 years. Parameter values were mainly obtained from literature and from RA patients screened for CV diseases at the Radboud University Medical Centre, Nijmegen, The Netherlands. The primary outcome was incremental cost‐effectiveness expressed as costs per quality‐adjusted life year (QALY) gained. Probabilistic sensitivity analysis was performed and described in willingness‐to‐pay curves; several scenarios were built.ResultsIn the base case scenario, in 82% of the simulations, screening proved to be dominant compared to no screening. The mean QALY gain was 0.09 (95% percentile −0.07, 0.27), and the mean cost savings were €−1,057 (95% percentile −€2,825, €333). Different scenarios showed small differences in cost‐effectiveness; the probability that screening is dominant remained high with the lowest probability being 50% for a very conservative scenario.ConclusionScreening for CV events in RA patients was estimated to be cost‐effective with high chances of being less expensive and more effective. These results support endorsement of screening for CV risk in patients with RA.
Impact of Obesity on Remission and Disease Activity in Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis
Authors: Liu Yang , Hazlewood Glen S. , Kaplan Gilaad G. , Eksteen Bertus , Barnabe Cheryl 
Published: May 2016

ObjectiveTo summarize the relationship between obesity and remission in rheumatoid arthritis (RA); secondary objectives were to summarize other measures of treatment response and mortality in RA.MethodsMedline and Embase searches were performed in March 2016 using relevant MeSH and keyword terms for obesity and RA. Articles were selected if they reported estimates for achieving remission in obese subjects relative to other body mass index (BMI) categories, or changes in composite or individual disease activity measures or patient‐reported outcomes during therapy, or mortality rates, in relation to BMI category or on a continuous scale. Remission outcomes were conducive to meta‐analysis, and all other outcomes were summarized.ResultsA total of 3,368 records were screened; we included 8 reporting remission rates, 9 reporting disease activity measures or patient‐reported outcomes, and 3 examining mortality by obesity status or BMI. Obese patients attain remission less frequently than nonobese and/or normal‐weight patients. In adjusted models, obese patients demonstrated lower odds of achieving remission (pooled odds ratio [OR] 0.57 [95% confidence interval (95% CI) 0.45, 0.72]) and sustained remission (pooled OR 0.49 [95% CI 0.32, 0.74]) relative to nonobese subjects. Most studies found obese patients to have worse Disease Activity Scores or Disease Activity Scores in 28 joints, tender joint counts, inflammatory markers, patient global evaluation scores, pain scores, and physical function scores during followup, but not worse swollen joint counts. Obesity was not associated with increased mortality.ConclusionObesity decreases the odds of achieving remission in RA and negatively impacts disease activity and patient‐reported outcomes during therapy. Interventions to reduce BMI should be investigated for their ability to improve disease outcomes.
ErbB2 blockade with Herceptin (trastuzumab) enhances peripheral nerve regeneration after repair of acute or chronic peripheral nerve injury
Authors: Hendry J. Michael , Alvarez‐Veronesi M. Cecilia , Placheta Eva , Zhang Jennifer J. , Gordon Tessa , Borschel Gregory H. 
Published: May 2016

ObjectiveAttenuation of the growth supportive environment within the distal nerve stump after delayed peripheral nerve repair profoundly limits nerve regeneration. Levels of the potent Schwann cell mitogen neuregulin and its receptor ErbB2 decline during this period, but the regenerative impact of this change is not completely understood. Herein, the ErbB2 receptor pathway is inhibited with the selective monoclonal antibody Herceptin (trastuzumab) to determine its significance in regulating acute and chronic regeneration in a rat hindlimb.MethodsThe common peroneal nerve of Sprague–Dawley rats was transected and repaired immediately or after 4 months of chronic denervation, followed by administration of Herceptin or saline solution. Regenerated motor and sensory neurons were counted using a retrograde tracer 1, 2, or 4, weeks after repair. Distal myelinated axon outgrowth after 4 weeks was quantified using histomorphometry. Immunofluorescent imaging was used to evaluate Schwann cell proliferation and epidermal growth factor receptor (EGFR) activation in the regenerating nerves.ResultsHerceptin administration increased the rate of motor and sensory neuron regeneration and the number of proliferating Schwann cells in the distal stump after the first week. Herceptin also increased the number of myelinated axons that regenerated 4 weeks after immediate and delayed repair. Reduced EGFR activation was observed using immunofluorescent imaging.InterpretationInhibition of the ErbB2 receptor with Herceptin unexpectedly enhances nerve regeneration after acute and delayed nerve repair. This finding raises the possibility of using targeted molecular therapies to improve outcomes of peripheral nerve injuries. The mechanism may involve a novel inhibitory association between ErbB2 and EGFR. Ann Neurol 2016;80:112–126
A β‐Lactamase‐Imprinted Responsive Hydrogel for the Treatment of Antibiotic‐Resistant Bacteria
Authors: Li Wen , Dong Kai , Ren Jinsong , Qu Xiaogang 
Published: May 2016

AbstractAntibiotics play important roles in infection treatment and prevention. However, the effectiveness of antibiotics is now threatened by the prevalence of drug‐resistant bacteria. Furthermore, antibiotic abuse and residues in the environment cause serious health issues. In this study, a stimuli‐responsive imprinted hydrogel was fabricated by using β‐lactamase produced by bacteria for deactivating antibiotics as the template molecule. The imprinted hydrogel could initially trap β‐lactamase excreted by drug‐resistant bacteria, thus making bacteria sensitive to antibiotics. After the bactericidal treatment, the “imprinted sites” on the hydrogel could be reversibly abolished with a temperature stimulus, which resulted in the reactivation of β‐lactamase to degrade antibiotic residues. We also present an example of the use of this antibacterial design to treat wound infection.
Trace H2O2‐Assisted High‐Capacity Tungsten Oxide Electrochromic Batteries with Ultrafast Charging in Seconds
Authors: Zhao Jinxiong , Tian Yuyu , Wang Zhen , Cong Shan , Zhou Di , Zhang Qingzhu , Yang Mei , Zhang Weikun , Geng Fengxia , Zhao Zhigang 
Published: May 2016

AbstractA recent technological trend in the field of electrochemical energy storage is to integrate energy storage and electrochromism functions in one smart device, which can establish efficient user–device interactions based on a friendly human‐readable output. This type of newly born energy storage technology has drawn tremendous attention. However, there is still plenty of room for technological and material innovation, which would allow advancement of the research field. A prototype Al‐tungsten oxide electrochromic battery with interactive color‐changing behavior is reported. With the assistance of trace amount of H2O2, the battery exhibits a specific capacity almost seven times that for the reported electrochromic batteries, up to 429 mAh g−1. Fast decoloration of the reduced tungsten oxide affords a very quick charging time of only eight seconds, which possibly comes from an intricate combination of structure and valence state changes of tungsten oxide. This unique combination of features may further advance the development of smart energy storage devices with suitability for user–device interactions.
Induced Potential in Porous Carbon Films through Water Vapor Absorption
Authors: Liu Kang , Yang Peihua , Li Song , Li Jia , Ding Tianpeng , Xue Guobin , Chen Qian , Feng Guang , Zhou Jun 
Published: May 2016

AbstractSustainable electrical potential of tens of millivolts can be induced by water vapor adsorption on a piece of porous carbon film that has two sides with different functional group contents. Integrated experiments, and Monte Carlo and ab initio molecular dynamics simulations reveal that the induced potential originates from the nonhomogeneous distribution of functional groups along the film, especially carboxy groups. Sufficient adsorbed water molecules in porous carbon facilitate the release of protons from the carboxy groups, resulting in a potential drop across the carbon film because of the concentration difference of the released free protons on the two sides. The potential utilization of such a phenomenon is also demonstrated by a self‐powered humidity sensor.
Regio‐, Stereo‐, and Atropselective Synthesis of C60 Fullerene Bisadducts by Supramolecular‐Directed Functionalization
Authors: Bottari Giovanni , Trukhina Olga , Kahnt Axel , Frunzi Michael , Murata Yasujiro , Rodríguez‐Fortea Antonio , Poblet Josep M. , Guldi Dirk M. , Torres Tomás 
Published: May 2016

AbstractThe regio‐ and stereocontrolled synthesis of fullerene bisadducts is a topic of increasing interest in fullerene chemistry and a key point for the full exploitation of these derivatives in materials science. In this context, while the tether‐directed remote functionalization strategy offers a valid approach to this synthetic challenge, no examples of such control have yet been reported using nontethered species. Presented here is a conceptually novel, supramolecular‐directed functionalization approach in which noncovalent interactions between untethered residues have been used, for the first time, to amplify (>2800‐fold) the regio‐, stereo‐, and atropselective formation of a C60 fullerene bisadduct racemate from a complex mixture of 130 bisadducts. Remarkably, both enantiomers, which present a sterically demanding cis‐1 C60 addition pattern, represent the first examples of fullerene derivatives which combine central, axial, and helical chirality.
Flexible Aqueous Lithium‐Ion Battery with High Safety and Large Volumetric Energy Density
Authors: Dong Xiaoli , Chen Long , Su Xiuli , Wang Yonggang , Xia Yongyao 
Published: May 2016

AbstractA flexible and wearable aqueous lithium‐ion battery is introduced based on spinel Li1.1Mn2O4 cathode and a carbon‐coated NASICON‐type LiTi2(PO4)3 anode (NASICON=sodium‐ion super ionic conductor). Energy densities of 63 Wh kg−1 or 124 mWh cm−3 and power densities of 3 275 W kg−1 or 11.1 W cm−3 can be obtained, which are seven times larger than the largest reported till now. The full cell can keep its capacity without significant loss under different bending states, which shows excellent flexibility. Furthermore, two such flexible cells in series with an operation voltage of 4 V can be compatible with current nonaqueous Li‐ion batteries. Therefore, such a flexible cell can potentially be put into practical applications for wearable electronics. In addition, a self‐chargeable unit is realized by integrating a single flexible aqueous Li‐ion battery with a commercial flexible solar cell, which may facilitate the long‐time outdoor operation of flexible and wearable electronic devices.
Disposable potentiometric citrate sensor based on polypyrrole‐doped films for indirect determination of sildenafil in pharmaceuticals formulations
Authors: Ochiai Leticia M. , Bindewald Eduardo H. , Mengarda Priscilla , Marcolino‐Junior Luiz H. , Bergamini Márcio F 
Published: May 2016

ABSTRACTA new sensitive and selective disposable potentiometric sensor based on polypyrrole (PPy) films for determination of sildenafil citrate (SC) was proposed. The pyrrole polymerization was performed in presence of citrate ions under galvanostatic conditions which resulted in a membrane of PPy doped with citrate anion at graphite pencil electrode surface. Experimental conditions (e.g., pH and conditioning time) and instrumental parameters (e.g., current density and electrical charge) were evaluated in order to reach the best potentiometric response for the proposed sensor. Under optimized conditions, the device presented a linear dynamic range (LDR) for citrate ions concentrations varying from 0.034 to 1.7 mmol L−1 with a Nernstian slope of 57.2 mV dec−1 and a limit of detection (LOD) of 30 µmol L−1. The developed potentiometric sensor was applied for sildenafil citrate (SC) determination (pharmaceutical formulations) and results compared with an official spectrophotometric method indicating a good agreement for a confidence level of 95%. Effect of concomitants species on the potentiometric response of the proposed device and morphologic characterization using microscopy of atomic force (AFM) were realized. The surface roughness of PPy films (synthesized in citrate solution and chloride) showed poorly affected by changing the doping anion, probably because the polypyrrole nodules grow three‐dimensionally simultaneously. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43762.
Effect of surface modification on the interface quality between hemp and linear medium‐density polyethylene
Authors: Chimeni Désiré Yomeni , Toupe Jean Luc , Dubois Charles , Rodrigue Denis 
Published: May 2016

ABSTRACTIn this work, hemp fibers (mercerized or not) were modified by a coupling agent (maleated polyethylene) to evaluate the level of interfacial improvement related to wettability or adhesion in LMDPE composites. To do so, different analyses in the solid (thermogravimetric analysis, dynamic mechanical analysis, and scanning electron microscopy) and melt (rheology) states were combined. From the results obtained, it can be shown that mercerization mostly controls the level of wettability (physical contact) of the fibers, while the addition of a coupling agent mostly controls interfacial adhesion (chemical interactions). These conclusions were obtained based on shifts in transition temperatures (Tg and Tα), as well as maxima in van Gurp–Palmen plots. Overall, the best properties were obtained when mercerization was combined with coupling agent addition under optimized processing conditions. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43802.
Effect of ultrafine talc on crystallization and end‐use properties of poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate)
Authors: Vandewijngaarden Jens , Murariu Marius , Dubois Philippe , Carleer Robert , Yperman Jan , D'Haen Jan , Peeters Roos , Buntinx Mieke 
Published: May 2016

ABSTRACTPoly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHBHHx) is a highly versatile polyhydroxyalkanoate. To enhance its slow crystallization, the performance of ultra‐fine talc (median diameter of 1 µm) as a nucleating agent is studied. This study focuses on crystallization, but also on the effect on fundamental properties (i.e., thermal stability) and selected end‐use properties (i.e., color, opacity, tensile properties, and gas permeability), to assess its applicability for food packaging purposes. Samples containing 0.5, 1, and 2 wt % were prepared through melt blending and compression molding. First, it was proven that ultra‐fine talc is a highly performant nucleating agent for PHBHHx. The isothermal crystallization half time at 70 °C was reduced to 97% by adding 2 wt % of talc, which could greatly improve the processability of PHBHHx. Thermal stability increased with 3–4 °C, due to increased barrier effect. Permeability for O2, CO2, and water vapor increased slightly upon addition of 0.5 wt % and 1 wt % talc, but decreased at 2 wt % talc. Nevertheless, the results remained within the same applicability range. An acceptable total color change of 0.9 was observed. Furthermore, the PHBHHx matrix was rendered stiffer (Young's modulus increased with 100 MPa), while showing hardly any change in elongation at break or tensile strength. Overall, it can be concluded that ultrafine talc is a very efficient nucleating agent for PHBHHx. Besides the beneficial effect on crystallization, the ultrafine talc hardly influenced any other property, which could prove to be of high added value for the application of these composites as food packaging material. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43808.
Silver nanowire network embedded in polydimethylsiloxane as stretchable, transparent, and conductive substrates
Authors: Kim JinHoon , Park Jaeyoon , Jeong Unyong , Park Jin‐Woo 
Published: May 2016

ABSTRACTHighly stretchable transparent conductors where Ag nanowire networks (AgNWs) are reliably embedded into a polydimethylsiloxane (PDMS) substrate are presented. In spite of the weak physical and chemical interaction between Ag nanowires and PDMS, a significantly high transfer efficiency and uniform embedding of AgNW percolation mesh electrodes into PDMS was achieved by simply coating aerogels onto the AgNWs and using water‐assisted transfer. By the failure‐free transfer and reliable bonding with the substrate, the conductive PDMS with embedded AgNWs that exhibits a sheet resistance (Rs) of 15 Ω/sq and 80% optical transmittance (T) are reported here. The PDMS films accommodate tensile strains up to 70% and a cyclic strain of 25% for more than 100 cycles, with subsequent Rs values as low as 90 and 27 Ω/sq, respectively. The T of this conductive PDMS is more than 25% higher than that of networks of CNTs, Cu nanowires, and hybrid composites of CNTs and graphene embedded in elastomer films such as PDMS, polyurethane, and Ecoflex. The simple and reproducible fabrication allows the extensive study and optimization of the stretchability of the meanders in terms of humidity, thickness, and substrate. The results provide new insights for designing stretchable electronics. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43830.