bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic musculoskeletal pain in European older adults: Cross‐national and gender differences
Authors: Cimas M. , Ayala A. , Sanz B. , Agulló‐Tomás M.S. , Escobar A. , Forjaz M.J. 
Published: December 2017

AbstractBackgroundIn an ageing Europe, chronic pain is a major public health problem, but robust epidemiological data are scarce. This study aimed to analyse the prevalence of and factors associated with chronic musculoskeletal pain by gender in older adults of 14 European countries.MethodsA cross‐sectional study was performed from wave 5 of the Survey of Health, Ageing and Retirement in Europe (SHARE). The study included people ≥50 years residing in Austria, Belgium, Czech Republic, Denmark, Estonia, France, Germany, Italy, Luxembourg, the Netherlands, Slovenia, Spain, Sweden and Switzerland. Chronic pain was defined as being bothered by joint and/or back pain for the previous 6 months. Multivariable Poisson regression models with robust variance were performed to analyse prevalence ratio by covariates, stratified by sex.ResultsA total of 61,157 participants were included. Overall prevalence of chronic musculoskeletal pain was 35.7% (28.8–31.7), ranging from 18.6% (17.1–20.1) for Switzerland to 45.6% (43.3–47.8) for France. Prevalence was higher in women than in men: 41.3% (40.2–42.4) versus 29.1% (28.0–30.3). Chronic musculoskeletal pain was lower in men aged >75 years (PR = 0.82; 0.72–0.92) than the younger (50–59) group. Separated/divorced status presented opposite effects among men (PR = 0.85; 0.76–0.96) and women (PR = 1.12; 1.03–1.21) compared with married, and unemployment was a significant factor in men (PR = 1.21; 95% CI 1.02–1.43) compared with employed.ConclusionsMusculoskeletal pain in older European adults is very frequent, especially in women, with large differences depending on the country of residence. Health policy makers should prioritize strategies aimed at improving the prevention and management of chronic musculoskeletal pain in Europe.SignificanceThis study provides epidemiological data of chronic musculoskeletal pain in older adults. Reported differences contribute to highlight the relevance of considering a gender perspective in chronic musculoskeletal pain research. Cross‐national comparison also offers a map of differences that improves the knowledge of this chronic condition in Europe.
A Graphene Oxide‐DNA Electrochemical Sensor Based on Glassy Carbon Electrode for Sensitive Determination of Methotrexate
Authors: Chen Jincheng , Fu Bo , Liu Tailin , Yan Zhihong , Li Kang 
Published: December 2017

AbstractMethotrexate (MTX) was used as an anti‐cancer drug, but its excessive use can cause serious side effects, it was necessary to monitor MTX in vivo. In this report, DNA was immobilized on a glassy carbon electrode (GCE) modified with graphene oxide (GO) to develop an electrochemical sensor for sensitive determination of MTX for the first time. The adsorptive voltammetric behaviors of MTX on DNA sensor were investigated using differential pulse voltammetry (DPV). The peak current response of guanine in DNA was used as a determination signal of MTX in acetate buffer solution pH 4.6. Voltammetric investigations revealed that the proposed method could determine MTX in the concentration range from 5.5×10−8 to 2.2×10−6 mol L−1 with a lower detection limit of 7.6×10−9 mol L−1 (S/N=3). The method was applied to detect MTX in human blood serum and diluted urine samples with excellent recoveries of 97.4–102.5 %. Compared with the previous studies, the DNA/GO/GCE electrode constructed by us based on the change rate of guanine current (R%) in DNA, proportionally reflecting the MTX concentration, is simple and sensitive.
1‐Ethyl‐3‐Methyl‐Imidazolium Bis (Trifluoromethane‐ sulfonyl) Imide as an Electrolyte Additive in LiFePO4‐ Based Batteries for Suppressing Aluminum Corrosion
Authors: Shangguan Xuehui , Jia Guofeng , Li Faqiang , Liu Suqin , Yang Guowei , Wu Kang , Wu Zhijian 
Published: December 2017

AbstractLithium bis (trifluoromethanesulfonyl) imide (LiTFSI) is a potentially useful electrolyte salt for use in Li‐ion batteries. LiTFSI, however, is associated with severe corrosion of Al current collectors. This study investigates the ionic liquid 1‐ethyl‐3‐methyl‐imidazolium bis (trifluoromethanesulfonyl) imide (EMITFSI) as an Al corrosion inhibitor in LiTFSI electrolytes. Different concentrations of EMITFSI are used as additives in 1 m LiTFSI‐based electrolytes to systematically assess the performance of lithium iron phosphate (LiFePO4) cathodes. The results from electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), Cyclic voltammetry (CV) indicate that adding EMITFSI into LiTFSI‐based electrolytes can effectively prevent severe corrosion of Al caused by LiTFSI‐based electrolytes. The LiFePO4 cells that use 1 m LiTFSI+11 % EMITFSI‐based electrolytes demonstrate a superior rate capability and cycling stability when compared to cells that use the LiTFSI‐based electrolyte.
Numerical Simulation of the Crack Formation in the Quenched Poly(l‐lactic acid) Spherulites
Authors: Liu Yanping , Wei Hanghang , Wang Junli , Li Qian 
Published: December 2017

AbstractThe quenching process of poly(l‐lactic acid) spherulites obtained by isothermal crystallization is simulated by ANSYS software in order to study the mechanism of crack formation. Regular concentric circular or hexagon crack is found by polarizing optical microscope and scanning electron microscope. The rapid temperature variation which brings large thermal stress is considered to be the main reason for the crack, so a spherulite with diameter of 160 µm is modeled by ANSYS to compute the transient change of thermal stress. According to the temperature nephogram, it is found that the spherulites temperature almost reduces to zero during 1 s, also the thermal stress dropped by five orders of magnitude. The stress fluctuation of 35 nodes, which are equally spaced from spherulite center to outer, present regular attenuation of vibration periodically from 10−6 to 10−4 s while the peak values are different from each other. Furthermore, the differential result of the peak value shows a bell‐shaped curve while the maximum difference between two adjacent nodes reaches 0.12 MPa. Although insufficient of boundary condition will introduce error of calculation, this research is still an important attempt for simulation technique to solve problem in polymer crystallization.
Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice
Authors: Russell Aaron P. , Ghobrial Lobna , Ngo Shyuan , Yerbury Justin , Zacharewicz Evelyn , Chung Roger , Lamon Séverine 
Published: December 2017

ABSTRACTIntroduction: The pathology of amyotrophic lateral sclerosis (ALS) is associated with impaired RNA processing and microRNA (miRNA) dysregulation. Here we investigate the regulation of the members of the miRNA biogenesis pathways and total miRNA levels at different stages of the disease. Methods: Muscle, brain, and spinal cord tissue were obtained from presymptomatic, symptomatic, and end‐stage superoxide dismutase 1 (SOD1)G93A mice. miRNA and transcript levels were measured by quantitative polymerase chain reaction. Results: As the diseases progresses, several genes involved in miRNA biogenesis as well as the miRNA/total RNA (totRNA) ratio increased in the tibialis anterior (TA) muscle but not in the soleus or in neural tissue. Discussion: We propose that a dysregulation in the miRNA/totRNA ratio in the TA muscle from SOD1G93A mice reflects a pathological increase in miRNA biogenesis machinery. Alterations in the miRNA/totRNA ratio influence the levels of reference noncoding RNAs and may therefore potentially compromise the accuracy of commonly used miRNA normalization strategies. Muscle Nerve 57: 838–847, 2018
Association of Higher Daptomycin Dose (7 mg/kg or Greater) with Improved Survival in Patients with Methicillin‐Resistant Staphylococcus aureus Bacteremia
Authors: Timbrook Tristan T. , Caffrey Aisling R. , Luther Megan K. , Lopes Vrishali , LaPlante Kerry L. 
Published: December 2017

Study ObjectiveCurrent guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin‐resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this recommendation is from in vitro and case series studies. This study evaluated the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia.DesignRetrospective national cohort study.SettingVeterans Affairs medical centers.PatientsA total of 371 adults with MRSA bacteremia who were admitted between 2002 and 2015 and treated initially with vancomycin within 24 hours of initial culture collection and then switched to daptomycin therapy within 7 days; 138 patients (37.2%) received daptomycin doses higher than the daptomycin label dose (7 mg/kg or greater), and 233 (62.8%) received the daptomycin label dose (6 mg/kg).Measurements and Main ResultsClinical outcomes were compared among those who received the daptomycin label dose and those who received the higher dose using propensity score–matched Cox proportional hazards regression models. To identify dose partitioning associated with optimal survival, classification and regression tree (CART) analysis was used among patients, controlling for confounding with a 30‐day mortality disease risk score. Propensity score–matched 30‐day mortality was 8.6% (6/70 patients) among the higher dose group versus 18.6% (13/70 patients) among the label dose group (hazard ratio 0.31, 95% confidence interval 0.10–0.94). No significant differences were observed in inpatient mortality, length of stay, 30‐day readmission, or 30‐day S. aureus reinfection between groups. CART analysis resulted in doses of 7 mg/kg or greater providing benefit only among patients with higher (more than 51%) predicted probabilities of 30‐day mortality (p<0.001).ConclusionTo our knowledge, this is the first comparative effectiveness study of daptomycin doses in patients with MRSA bacteremia. Survival benefits were observed with doses higher than the daptomycin label dose (7 mg/kg or greater) for the treatment of MRSA bacteremia. These data suggest that higher doses than the daptomycin label dose may be preferred over the label dose for improving clinical outcomes in patients with MRSA bacteremia.
Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites
Authors: Kumar Ammu Prasanna , Nguyen Minh N. , Verma Chandra , Lukman Suryani 
Published: December 2017

AbstractCatalytic proteins such as human protein tyrosine phosphatase 1B (PTP1B), with conserved and highly polar active sites, warrant the discovery of druggable nonactive sites, such as allosteric sites, and potentially, therapeutic small molecules that can bind to these sites. Catalyzing the dephosphorylation of numerous substrates, PTP1B is physiologically important in intracellular signal transduction pathways in diverse cell types and tissues. Aberrant PTP1B is associated with obesity, diabetes, cancers, and neurodegenerative disorders. Utilizing clustering methods (based on root mean square deviation, principal component analysis, nonnegative matrix factorization, and independent component analysis), we have examined multiple PTP1B structures. Using the resulting representative structures in different conformational states, we determined consensus clustroids and used them to identify both known and novel binding sites, some of which are potentially allosteric. We report several lead compounds that could potentially bind to the novel PTP1B binding sites and can be further optimized. Considering the possibility for drug repurposing, we discovered homologous binding sites in other proteins, with ligands that could potentially bind to the novel PTP1B binding sites.
Assessment of data‐assisted prediction by inclusion of crosslinking/mass‐spectrometry and small angle X‐ray scattering data in the 12th Critical Assessment of protein Structure Prediction experiment
Authors: Tamò Giorgio E. , Abriata Luciano A. , Fonti Giulia , Dal Peraro Matteo 
Published: December 2017

AbstractIntegrative modeling approaches attempt to combine experiments and computation to derive structure‐function relationships in complex molecular assemblies. Despite their importance for the advancement of life sciences, benchmarking of existing methodologies is rather poor. The 12th round of the Critical Assessment of protein Structure Prediction (CASP) offered a unique niche to benchmark data and methods from two kinds of experiments often used in integrative modeling, namely residue‐residue contacts obtained through crosslinking/mass‐spectrometry (CLMS), and small‐angle X‐ray scattering (SAXS) experiments. Upon assessment of the models submitted by predictors for 3 targets assisted by CLMS data and 11 targets by SAXS data, we observed no significant improvement when compared to the best data‐blind models, although most predictors did improve relative to their own data‐blind predictions. Only for target Tx892 of the CLMS‐assisted category and for target Ts947 of the SAXS‐assisted category, there was a net, albeit mild, improvement relative to the best data‐blind predictions. We discuss here possible reasons for the relatively poor success, which point rather to inconsistencies in the data sources rather than in the methods, to which a few groups were less sensitive. We conclude with suggestions that could improve the potential of data integration in future CASP rounds in terms of experimental data production, methods development, data management and prediction assessment.
Brain biopsy performed with the RONNA G3 system: a case study on using a novel robotic navigation device for stereotactic neurosurgery
Authors: Dlaka Domagoj , Švaco Marko , Chudy Darko , Jerbić Bojan , Šekoranja Bojan , Šuligoj Filip , Vidaković Josip , Almahariq Fadi , Romić Dominik 
Published: December 2017

AbstractBackgroundRobotic neuronavigation is becoming an important tool for neurosurgeons. We present a case study of a frameless stereotactic biopsy guided by the RONNA G3 robotic neuronavigation system.MethodsA 45 year‐old patient with a history of vertigo, nausea and vomiting was diagnosed with multiple periventricular lesions. Neurological status was unremarkable. A frameless robotic biopsy of a brain lesion was performed.ResultsThree tissue samples were obtained. There were no intraoperative or postoperative complications. Histological analysis showed a B‐cell lymphoma. After merging the preoperative CT scan with the postoperative MRI and CT scans, the measured error between the planned and the postoperatively measured entry point was 2.24 mm and the measured error between the planned and postoperatively measured target point was 2.33 mm.ConclusionsThe RONNA G3 robotic system was used to navigate a Sedan brain biopsy needle to take tissue samples and could be a safe and precise tool for brain biopsy.
Zirconia‐Supported Cobalt Catalysts: Activity and Selectivity in NO Reduction by CO
Authors: Lima Thiago M. , Pereira Cristiane A. , Castelblanco William N. , Santos Camila M. B. , da Silva Sebastião W. , Santana Ricardo C. , Urquieta‐González Ernesto A. , Sartoratto Patrícia P. C. 
Published: December 2017

AbstractCobalt catalysts supported on tetragonal and monoclinic zirconia were prepared using a one‐pot procedure through the incorporation of a Co3O4 colloidal suspension during the support synthesis and evaluated in the reaction of NO reduction by CO. A better dispersion of the active phase was obtained by this method when compared to the conventional impregnation one. Furthermore, the crystalline phase of zirconia in the supports had a crucial effect in the dispersion of the cobalt species, being that the pure tetragonal phase led to a higher dispersion of the active phase. The one‐pot prepared tetragonal zirconia led to cobalt active species that consisted in well‐dispersed small agglomerates of Co3O4 and Co2+ species as oxo‐ions which displayed the best catalytic performance among the studied catalysts, with the highest NO conversion (75%) and high selectivity to N2 (85%) at 300 °C. These results show that the one‐pot methodology employed in this work has a strong potential to produce suitable catalysts for the abatement of NOx emissions.
MVP and College Success for First‐Year Students
Authors: Becker Karen A. 
Published: December 2017

AbstractThis chapter describes a Reading and Study Skills program and course that are offered to first‐year students who are underprepared or reluctant and who may be at risk for failure in other courses as well as at risk for long‐term retention and graduation. The course is discussed with respect to its parallels to the MVP model, and initial evidence of its success is provided. The MVP cycle is reflected in course design and process and in a textbook created specifically to accompany the course.
Assessing Motivation to Improve Learning: Practical Applications of Keller's MVP Model and ARCS‐V Design Process
Authors: Angelo Thomas A. 
Published: December 2017

AbstractThis chapter applies John Keller's MVP model and, specifically, adapts the ARCS‐V components of that model—defined and described in Chapter 1 of this issue of New Directions for Teaching and Learning—as a frame for exploring practical, research‐based assessment, and feedback strategies and tools teachers can use to help students enhance, manage, and sustain their own motivation to learn.
Phyllis M. Tookey Kerridge and the science of audiometric standardization in Britain
Authors: VIRDI JAIPREET , MCGUIRE COREEN 
Published: December 2017

AbstractThe provision of standardized hearing aids is now considered to be a crucial part of the UK National Health Service. Yet this is only explicable through reference to the career of a woman who has, until now, been entirely forgotten. Dr Phyllis Margaret Tookey Kerridge (1901–1940) was an authoritative figure in a variety of fields: medicine, physiology, otology and the construction of scientific apparatus. The astounding breadth of her professional qualifications allowed her to combine features of these fields and, later in her career, to position herself as a specialist to shape the discipline of audiometry. Rather than framing Kerridge in the classic ‘heroic-woman’ narrative, in this article we draw out the complexities of her career by focusing on her pursuit of standardization of hearing tests. Collaboration afforded her the necessary networks to explore the intricacies of accuracy in the measurement of hearing acuity, but her influence was enhanced by her ownership of Britain's first Western Electric (pure-tone) audiometer, which she placed in a specially designed and unique ‘silence room’. The room became the centre of Kerridge's hearing aid clinic that, for the first time, allowed people to access free and impartial advice on hearing aid prescription. In becoming the guardian expert and advocate of the audiometer, Kerridge achieved an objectively quantified approach to hearing loss that eventually made the latter an object of technocratic intervention.
Online prevention of disordered eating in at-risk young-adult women: a two-country pragmatic randomized controlled trial
Authors: Wilksch Simon M. , O'Shea Anne , Taylor C. Barr , Wilfley Denise , Jacobi Corinna , Wade Tracey D. 
Published: December 2017

AbstractBackgroundDisordered eating (DE) is a widespread, serious problem. Efficacious prevention programs that can be delivered at-scale are needed.MethodsA pragmatic randomized controlled trial of two online programs was conducted. Participants were young-adult women from Australia and New Zealand seeking to improve their body image.Media Smart-Targeted(MS-T) andStudent Bodies(SB) were both 9-module interventions released weekly, whilst control participants received positive body image information. Primary [Eating Disorder Examination–Questionnaire (EDE-Q) Global], secondary (DE risk factors) and tertiary (DE) outcome measures were completed at baseline, post-program, 6- and 12-month follow-up.ResultsBaseline was completed by 608 women (Mage = 20.71 years); 33 were excluded leaving 575 randomized to:MS-T(N= 191); SB(N= 190) or control (N= 194). Only 66% of those randomized toMS-TorSBaccessed the intervention and were included in analyses with controls; 78% of this sample completed measures subsequent to baseline. Primary intent-to-treat (ITT) analyses revealed no differences between groups, while measure completer analyses foundMS-Thad significantly lower EDE-Q Global than controls at 12-month follow-up. Secondary ITT analyses foundMS-Tparticipants reported significantly higher quality of life–mental relative to bothSBand controls (6-month follow-up), whileMS-Tand controls had lower clinical impairment relative toSB(post-program). Amongst measure completers,MS-Tscored significantly lower than controls andSBon 5 variables. Of those with baseline DE,MS-Tparticipants were significantly less likely than controls to have DE at 12-month follow-up.ConclusionsGiven both programs were not therapist-moderated,MS-Thas potential to achieve reductions in DE risk at low implementation costs.
The functional and developmental role of imitation in the (a)typical brain
Authors: Casartelli Luca , Parma Valentina 
Published: December 2017

AbstractKeven & Akins (K&A) propose a biologically plausible view of neonatal imitation based on the analysis of sensorimotor development. Here, we consider imitation in the general context of motor cognition, taking examples from both typical and atypical development. Specifically, we will discuss the functional role of imitation, its multi-level nature, and its anomalous features in autism.
Does early motor development contribute to speech perception?
Authors: Choi Dawoon , Kandhadai Padmapriya , Danielson D. Kyle , Bruderer Alison G. , Werker Janet F. 
Published: December 2017

AbstractAt the end of the target article, Keven & Akins (K&A) put forward a challenge to the developmental psychology community to consider the development of complex psychological processes – in particular, intermodal infant perception – across different levels of analysis. We take up that challenge and consider the possibility that early emerging stereotypies might help explain the foundations of the link between speech perception and speech production.
When dyadic interaction is the context: Mimicry behaviors on the origin of imitation
Authors: Campos Ruth , Nieto Carmen 
Published: December 2017

AbstractKeven & Akins (K&A) redefine some of the neonatal imitation (NI) behaviors as developmental stereotypes. From a neuroconstructivist framework, those early gestures are also far from being considered as imitative behaviors. The cognitive substrate of imitation requires an interactive context to develop. Prior to intentional imitation, the dyad shows mimicry behaviors, which are automatic, but do not fade through development.
A major blow to primate neonatal imitation and mirror neuron theory
Authors: Fitch W. Tecumseh 
Published: December 2017

AbstractKeven & Akins' (K&A's) compelling new hypothesis explaining the developmental and neural basis of neonatal tongue protrusion has important implications for current understanding of primate imitation and the explanatory value of mirror neurons. If correct, this hypothesis eliminates a major source of evidence for neonatal imitation. I explore the implications this has for mirror neuron research and the arguments building upon them.