bluuebunny/crossref_metadata_2025_split huggingface dataset:
8-Cl-cAMP, The Old Dog with New Tricks: A Review
Authors: Vladan Bajic  , Lada Živkovic  , Andrea Cabarkapa  , Biljana Spremo Potparevic  
Published: November 2015

Current chemotherapeutic drugs act for the most part by killing cancer cells directly. Treatment with these drugs often can be harmful to normal cells and may cause incomplete elimination of the target cells, resulting in the recurrence of the disease. To coop with current treatments the path of biomodulation rather than cytotoxicity, has been seen in the role of cAMP in normal versus malignant cells. It has been found that an increase of cAMP levels in normal cells stimulates proliferation, and that in the same time cancerous cells are inhibited to proliferate. This inverted reaction has given the momentum for synthesis of various cAMP analogues and investigation of there antitumor activity. A number of analogues, such as 8-PIP-cAMP, 8-Br-CAMP or 8-HA-cAMP showed efficacy only in millimolar concentrations. Only one of them, 8-Cl-cAMP as specific analogue has achieved inhibition of proliferation and stimulation of apoptosis of malignant cells in low or micromole concentrations. Still, 25 years later the mechanism of action of 8-clcAMP has not been fully elucidated or defined. This review is to challenge these mechanisms of action and to set a view of the nature of 8-Cl-cAMP action.
Progressively Worsening Cyclic Rash: Diagnosis and Approach to Care
Authors: DeRosa Angela , Adams Shellee , Fee Erin Kathleen 
Published: November 2015

Abstract
Autoimmune progesterone dermatitis (AIPD) is an uncommon condition in which allergic dermatitis to endogenous progesterone manifests in cyclic cutaneous eruptions. In this case series, we present 3 patients with AIPD, each with unique presentations and medical histories emblematic of the disease. Cyclic dermatitis related to menses in a premenopausal woman should raise high clinical suspicion for AIPD, especially in the primary care or emergency setting. Because of the rarity of this disorder, this case series seeks to describe AIPD to medical providers of young women, as well as present relevant literature related to the disease. We propose clinical considerations for women of reproductive age with AIPD.
Fabrication and photoelectric properties of Er3+ and Yb3+ co-doped ZnO films
Authors: Feng Wei , Wang Xiangfu , Meng Lan , Yan Xiaohong 
Published: November 2015

Abstract
In this paper, the Er3+ and Yb3+ co-doped ZnO films deposited by a novel thermal decomposition method under different annealing temperature process have been reported. The effects of annealing temperature on the morphology and properties of the films are systematically studied. The resulting spectra demonstrate that the Er3+ and Yb3+ co-doped ZnO films possessed the property of up-conversion, converting IR light into visible light that can be absorbed by amorphous silicon solar cell. After all, inner photoelectric effect of the Er3+ and Yb3+ co-doped ZnO films in the amorphous as a light scattering layer are also found with an infrared 980 nm laser as excitation source.
Investigation of NH3 input partial pressure for N-polarity InGaN growth on GaN substrates by tri-halide vapor phase epitaxy
Authors: Hirasaki Takahide , Hasegawa Tomoyasu , Meguro Misaki , Thieu Quang Tu , Murakami Hisashi , Kumagai Yoshinao , Monemar Bo , Koukitu Akinori 
Published: November 2015

Abstract
The influence of NH3 input partial pressure on N-polarity InGaN grown by tri-halide vapor phase epitaxy was investigated. It was found that surface morphology, solid composition and optical properties were affected by NH3 input partial pressure. As shown in thermodynamic analyses, the indium content increased due to an increase in the driving force for InN deposition caused by increased NH3 input partial pressure. In addition, the deep level emission around 2.1 eV in photoluminescence measurements drastically decreased at higher NH3 input partial pressures. Ab initio calculations and subsequent secondary ion mass spectrometry measurements suggested the reduction of metal-vacancies and/or carbon impurity incorporation in the InGaN layers.
Subduction system and flat slab beneath the Eastern Cordillera of Colombia
Authors: Chiarabba Claudio , De Gori Pasquale , Faccenna Claudio , Speranza Fabio , Seccia Danilo , Dionicio Viviana , Prieto Germán A. 
Published: November 2015

AbstractSeismicity at the northern terminus of the Nazca subduction is diffused over a wide area containing the puzzling seismic feature known as the Bucaramanga nest. We relocate about 5000 earthquakes recorded by the Colombian national seismic network and produce the first 3‐D velocity model of the area to define the geometry of the lithosphere subducting below the Colombian Andes. We found lateral velocity heterogeneities and an abrupt offset of the Wadati‐Benioff zone at 5°N indicating that the Nazca plate is segmented by an E‐W slab tear, that separates a steeper Nazca segment to the south from a flat subduction to the north. The flat Nazca slab extends eastward for about 400 km, before dip increases to ∼50° beneath the Eastern Cordillera, where it yields the Bucaramanga nest. We explain this puzzling locus of intermediate‐depth seismicity located beneath the Eastern Cordillera of Colombia as due to a massive dehydration and eclogitization of a thickened oceanic crust. We relate the flat subducting geometry to the entrance at the trench at ca. 10 Ma of a thick ‐ buoyant oceanic crust, likely a volcanic ridge, producing a high coupling with the overriding plate. Sub‐horizontal plate subduction is consistent with the abrupt disappearance of volcanism in the Andes of South America at latitudes > 5°N.
Prediction of MeV electron fluxes throughout the outer radiation belt using multivariate autoregressive models
Authors: Sakaguchi Kaori , Nagatsuma Tsutomu , Reeves Geoffrey D. , Spence Harlan E. 
Published: November 2015

AbstractThe Van Allen radiation belts surrounding the Earth are filled with MeV‐energy electrons. This region poses ionizing radiation risks for spacecraft that operate within it, including those in geostationary orbit (GEO) and medium Earth orbit. To provide alerts of electron flux enhancements, 16 prediction models of the electron log‐flux variation throughout the equatorial outer radiation belt as a function of the McIlwain L parameter were developed using the multivariate autoregressive model and Kalman filter. Measurements of omnidirectional 2.3 MeV electron flux from the Van Allen Probes mission as well as >2 MeV electrons from the GOES 15 spacecraft were used as the predictors. Model explanatory parameters were selected from solar wind parameters, the electron log‐flux at GEO, and geomagnetic indices. For the innermost region of the outer radiation belt, the electron flux is best predicted by using the Dst index as the sole input parameter. For the central to outermost regions, at L ≧ 4.8 and L ≧ 5.6, the electron flux is predicted most accurately by including also the solar wind velocity and then the dynamic pressure, respectively. The Dst index is the best overall single parameter for predicting at 3 ≦ L ≦ 6, while for the GEO flux prediction, the KP index is better than Dst. A test calculation demonstrates that the model successfully predicts the timing and location of the flux maximum as much as 2 days in advance and that the electron flux decreases faster with time at higher L values, both model features consistent with the actually observed behavior.
New insights on the seismogenic potential of the Eastern Betic Shear Zone (SE Iberia): Quaternary activity and paleoseismicity of the SW segment of the Carrascoy Fault Zone
Authors: Martín‐Banda Raquel , García‐Mayordomo Julián , Insua‐Arévalo Juan M. , Salazar Ángel E. , Rodríguez‐Escudero Emilio , Álvarez‐Gómez Jose A. , Medialdea Alicia , Herrero María J. 
Published: November 2015

AbstractThe Carrascoy Fault (CAF) is one of the main active faults that form part of the Eastern Betic Shear Zone, a 450 km fault system that accommodates most of the convergence between the Eurasian (Iberia) and Nubian plates in the Betic Cordillera, south Spain. Although the CAF represents a major earthquake threat to the nearby City of Murcia, studies on its Quaternary tectonics and seismogenic potential are scarce to date. We present evidence that supports the division of the CAF into two overlapping segments with contrasting tectonic structure, Quaternary activity, and landform control: a SW segment, characterized by a broad fold‐and‐thrust zone similar to the forebergs defined in the Gobi‐Altai region, and a NE segment, characterized by a sharp mountain front controlled by strike‐slip tectonics. We attribute the differentiation into these two segments to the stresses associated with topography, which in turn is a consequence of the shortening component, at the middle Pleistocene, after circa 217.4 ka. For the SW segment we infer the occurrence of 9 to 11, Mw 6.7 paleoearthquakes in the last 30.2 kyr, and a slip rate of 0.37 ± 0.08 m/kyr. We date the occurrence of the last surface rupture event after 2750 B.P., and we estimate an average recurrence period of major events of 3.3 ± 0.7 kyr.
Copper‐Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2‐a]pyrimidin‐4(10H)‐ones using Cyanamide as a Building Block
Authors: Lou Zhenbang , Wu Xudong , Yang Haijun , Zhu Changjin , Fu Hua 
Published: November 2015

AbstractAn efficient and practical copper‐catalyzed domino synthesis of benzo[4,5]imidazo[1,2‐a]pyrimidin‐4(10H)‐ones has been developed. The protocol uses N‐(2‐halophenyl)‐3‐alkylpropiolamides and cyanamide as the starting materials, inexpensive copper(I) iodide and pipecolinic acid as the catalyst and ligand, and the corresponding products were obtained in moderate to good yields.magnified image
The role of acoustic signaling for spacing and group coordination in a nocturnal, pair‐living primate, the western woolly lemur (Avahi occidentalis)
Authors: Ramanankirahina Rindrahatsarana , Joly Marine , Scheumann Marina , Zimmermann Elke 
Published: November 2015

ABSTRACTObjectivesHow social groups govern their distribution in time and space is a central question in socioecology. The aim of this study is to explore the role of acoustic signaling for spacing and cohesiveness in a nocturnal, cohesive, pair‐living strepsirrhine.Material and MethodsThe study was conducted in northwestern Madagascar. Six pairs ofAvahi occidentaliswere radio‐collared and home range usage, vocalizations and call‐associated behavior recorded using GPS‐based focal animal sampling. Home range size was analyzed using ArcView GIS 3.3. Calls were characterized by a multiparametric sound analysis.ResultsThree frequently used, acoustically distinct call types were identified: the avahee call, the whistle call, and the growling call, the latter is a soft; the two others are loud calls. Call types are given by both sexes and convey individually‐specific signatures. Call types are used primarily in the locomotion context in the non‐core‐area of home ranges. The least common avahee call is responded by the avahee call from farther away. The more common whistle call, given when partners become visually isolated, and the growling call emitted at close distances, were answered by the whistle and the growling call. Results suggest a spacing function for the avahee call and group coordination functions for the other call types.DiscussionOur study provides first empirical evidence for a nocturnal, cohesive pair‐living strepsirrhine that vocal signaling represents an important mechanism for spacing, group coordination and decision making. Findings contribute to a better understanding of the evolutionary roots of primate vocal communication. Am J Phys Anthropol 159:466–477, 2016. © 2015 Wiley Periodicals, Inc.
Lichtgesteuerte Umwandlung zwischen einem selbstassemblierten Dreieck und einer rhombenkuboktaedrischen Sphäre
Authors: Han Muxin , Luo Yuansu , Damaschke Bernd , Gómez Laura , Ribas Xavi , Jose Anex , Peretzki Patrick , Seibt Michael , Clever Guido H. 
Published: November 2015

AbstractDurch äußere Stimuli ausgelöste Strukturumwandlungen spielen bei vielen biologischen Vorgängen eine wichtige Rolle, oft als Teil kinetisch gesteuerter Szenarien. Licht hat sich bei supramolekularen Nachbildungen solcher Systeme als perfekter externer Trigger erwiesen. Hier berichten wir über die lichtgesteuerte Strukturumwandlung eines kleinen, selbstassemblierten Pd3L6‐Ringes, aufgebaut aus photochromen Dithienylethen(DTE)‐Liganden, zu einer rhombenkuboktaedrischen Pd24L48‐Sphäre mit einem Durchmesser von 6.4 nm. Je nach Wahl der Wellenlänge kann dieser Prozess vollständig umgekehrt werden, wie durch NMR‐, UV/Vis‐ und MS‐Messungen gezeigt werden konnte. Zudem konnte die Bildung der Sphäre mittels AFM, TEM und GISAXS nachgewiesen werden. Aufgrund unterschiedlicher Konformationen der Photoschalter in den isomeren Konstrukten zeigen die Geschwindigkeitskonstanten der Umwandlung zwischen beiden Strukturen eine starke Abhängigkeit von der Schaltrichtung.
Goldkatalysierte C‐H‐Anellierung von Anthranilen mit Alkinen: flexible, atomökonomische Synthese ungeschützter 7‐Acylindole
Authors: Jin Hongming , Huang Long , Xie Jin , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: November 2015

AbstractDie goldkatalysierte C‐H‐Anellierung von Anthranilderivaten mit Alkinen eröffnet eine einfache, flexible und atomökonomische einstufige Route zu ungeschützten 7‐Acylindolen. Über eine α‐Iminogoldcarben‐Zwischenstufe, die in einer intermolekularen Reaktion generiert wird, erfolgt eine ortho‐Aryl‐C‐H‐Funktionalisierung zur Zielverbindung. Die Transformation zeichnet sich durch ein breites Substratspektrum und milde Bedingungen aus. Darüber hinaus stellen die erhaltenen Indole eine vielseitige Plattform für den Aufbau verschiedenster Indolyl‐Grundgerüste dar.
Li2C2, a High‐Capacity Cathode Material for Lithium Ion Batteries
Authors: Tian Na , Gao Yurui , Li Yurong , Wang Zhaoxiang , Song Xiaoyan , Chen Liquan 
Published: November 2015

AbstractAs a typical alkaline earth metal carbide, lithium carbide (Li2C2) has the highest theoretical specific capacity (1400 mA h g−1) among all the reported lithium‐containing cathode materials for lithium ion batteries. Herein, the feasibility of using Li2C2 as a cathode material was studied. The results show that at least half of the lithium can be extracted from Li2C2 and the reversible specific capacity reaches 700 mA h g−1. The CC bond tends to rotate to form C4 (CC⋅⋅⋅CC) chains during lithium extraction, as indicated with the first‐principles molecular dynamics (FPMD) simulation. The low electronic and ionic conductivity are believed to be responsible for the potential gap between charge and discharge, as is supported with density functional theory (DFT) calculations and Arrhenius fitting results. These findings illustrate the feasibility to use the alkali and alkaline earth metal carbides as high‐capacity electrode materials for secondary batteries.
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity
Authors: Zhao Weining , Lorenz Nicola , Jung Kirsten , Sieber Stephan A. 
Published: November 2015

AbstractVibrio is a model organism for the study of quorum sensing (QS) signaling and is used to identify QS‐interfering drugs. Naturally occurring fimbrolides are important tool compounds known to affect QS in various organisms; however, their cellular targets have so far remained elusive. Here we identify the irreversible fimbrolide targets in the proteome of living V. harveyi and V. campbellii via quantitative mass spectrometry utilizing customized probes. Among the major hits are two protein targets with essential roles in Vibrio QS and bioluminescence. LuxS, responsible for autoinducer 2 biosynthesis, and LuxE, a subunit of the luciferase complex, were both covalently modified at their active‐site cysteines leading to inhibition of activity. The identification of LuxE unifies previous reports suggesting inhibition of bioluminescence downstream of the signaling cascade and thus contributes to a better mechanistic understanding of these QS tool compounds.
Light‐Controlled Interconversion between a Self‐Assembled Triangle and a Rhombicuboctahedral Sphere
Authors: Han Muxin , Luo Yuansu , Damaschke Bernd , Gómez Laura , Ribas Xavi , Jose Anex , Peretzki Patrick , Seibt Michael , Clever Guido H. 
Published: November 2015

AbstractStimuli‐responsive structural reorganizations play an important role in biological processes, often in combination with kinetic control scenarios. In supramolecular mimics of such systems, light has been established as the perfect external trigger. Here, we report on the light‐driven structural rearrangement of a small, self‐assembled Pd3L6 ring based on photochromic dithienylethene (DTE) ligands into a rhombicuboctahedral Pd24L48 sphere measuring about 6.4 nm across. When the wavelength is changed, this interconversion can be fully reversed, as confirmed by NMR and UV/Vis spectroscopy as well as mass spectrometry. The sphere was visualized by AFM, TEM, and GISAXS measurements. Due to dissimilarities in the photoswitch conformations, the interconversion rates between the two assemblies are drastically different in the two directions.
Numerical simulation of soot combustion process in a bubbling fluidized bed with segregation behavior
Authors: Zhong Hanbin , Lan Xingying , Gao Jinsen 
Published: November 2015

AbstractAlthough only about 1 wt.% soot is formed after asphalt gasification, it is generally recognized that handling of the soot places a considerable financial burden on the integrated deasphalting–gasification process, because the disposal of the filter soot to landfill or other destinations causes serious environment problems. The bubbling fluidized bed combustion process, which takes the advantage of segregation behavior, was proposed to solve soot handling problem. A multi‐fluid model based on an Eulerian–Eulerian approach was developed to reveal the characteristics of segregation and combustion behavior. The distributions of flow, temperature, and species concentration were obtained, and the simulation results demonstrate that the segregation behavior is beneficial to discharge particle mixtures with low soot content at the bottom of the bed, which will favor the following vanadium recovering process. The effects of several key operating conditions, such as excess air coefficient, superficial gas velocity and initial static bed height were also discussed. © 2015 Curtin University of Technology and John Wiley & Sons, Ltd.
A Fast Model‐Predictive Speed Controller for Minimised Charge Consumption of Electric Vehicles
Authors: Schwickart Tim , Voos Holger , Hadji‐Minaglou Jean‐Régis , Darouach Mohamed 
Published: November 2015

AbstractThis paper presents the design of a real‐time implementable energy‐efficient model‐predictive cruise controller for electric vehicles including the driving speed reference generation. The controller is designed to meet the properties of a series‐production electric vehicle whose characteristics are identified and validated by measurements. The predictive eco‐cruise controller aims at finding the best compromise between speed‐reference tracking and energy consumption of the vehicle using an underlying dynamic model of the vehicle motion and charge consumption. The originally non‐linear motion model is transformed into a linear model mainly by using a coordinate transform. To obtain a piecewise linear approximation of the charge consumption map, the measured characteristics are approximated by a convex piecewise linear function represented as the maximum of a set of linear constraint functions. The reformulations finally lead to a model‐predictive control approach with quadratic cost function, linear prediction model and linear constraints that corresponds to a piecewise linear system behaviour and allows a fast real‐time implementation with guaranteed convergence. Simulation results of the closed‐loop operation finally illustrate the effectiveness of the approach.
Climatology of convective available potential energy (CAPE) inERA‐Interim reanalysis over West Africa
Authors: Meukaleuni Cyrille , Lenouo André , Monkam David 
Published: November 2015

AbstractSeasonal study of convective available potential energy (CAPE) is done using 6‐hERA‐Interim data over West Africa during 35 years (1979–2014). Climatology ofCAPEpresented in terms of seasonal means, variances and trends shows large values toward 12°–16°N with maxima during summer, according to higher relative humidity due to the arrival of monsoon in West Africa. Spectral analysis in the zone 10°–20°N/20°W–30°E, centered on the latitudes of maxima ofCAPEtrends at 12°–16°N toward inter‐tropical convergence zone (ITCZ) mean position in summer, shows significant power in the 3–5 day within the regions of tropical deep convection in connection with African easterly waves.
Risk adjustment models for short-term outcomes after surgical resection for oesophagogastric cancer
Authors: Fischer C , Lingsma H , Hardwick R , Cromwell D A , Steyerberg E , Groene O 
Published: November 2015

Abstract

Background
Outcomes for oesophagogastric cancer surgery are compared with the aim of benchmarking quality of care. Adjusting for patient characteristics is crucial to avoid biased comparisons between providers. The study objective was to develop a case-mix adjustment model for comparing 30- and 90-day mortality and anastomotic leakage rates after oesophagogastric cancer resections.

Methods
The study reviewed existing models, considered expert opinion and examined audit data in order to select predictors that were consequently used to develop a case-mix adjustment model for the National Oesophago-Gastric Cancer Audit, covering England and Wales. Models were developed on patients undergoing surgical resection between April 2011 and March 2013 using logistic regression. Model calibration and discrimination was quantified using a bootstrap procedure.

Results
Most existing risk models for oesophagogastric resections were methodologically weak, outdated or based on detailed laboratory data that are not generally available. In 4882 patients with oesophagogastric cancer used for model development, 30- and 90-day mortality rates were 2·3 and 4·4 per cent respectively, and 6·2 per cent of patients developed an anastomotic leak. The internally validated models, based on predictors selected from the literature, showed moderate discrimination (area under the receiver operating characteristic (ROC) curve 0·646 for 30-day mortality, 0·664 for 90-day mortality and 0·587 for anastomotic leakage) and good calibration.

Conclusion
Based on available data, three case-mix adjustment models for postoperative outcomes in patients undergoing curative surgery for oesophagogastric cancer were developed. These models should be used for risk adjustment when assessing hospital performance in the National Health Service, and tested in other large health systems.