bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition
Authors: Stuhlmiller Timothy J. , Zawistowski Jon S. , Chen Xin , Sciaky Noah , Angus Steven P. , Hicks Sean T. , Parry Traci L. , Huang Wei , Beak Ju Youn , Willis Monte S. , Johnson Gary L. , Jensen Brian C. 
Published: October 2017

Background
Most novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe. The basis for this distinction is unclear, as are the molecular effects of kinase inhibitors in the heart.

Methods and Results

We administered clinically relevant doses of sorafenib, sunitinib (cardiotoxic multitargeted kinase inhibitors), or erlotinib (a cardiosafe epidermal growth factor receptor inhibitor) to mice daily for 2 weeks. We then compared the effects of these 3 kinase inhibitors on the cardiac transcriptome using
RNA
seq and the cardiac kinome using multiplexed inhibitor beads coupled with mass spectrometry. We found unexpectedly broad molecular effects of all 3 kinase inhibitors, suggesting that target kinase selectivity does not define either the molecular response or the potential for cardiotoxicity. Using in vivo drug administration and primary cardiomyocyte culture, we also show that the cardiosafety of erlotinib treatment may result from upregulation of the cardioprotective signal transducer and activator of transcription 3 pathway, as co‐treatment with erlotinib and a signal transducer and activator of transcription inhibitor decreases cardiac contractile function and cardiomyocyte fatty acid oxidation.

Conclusions
Collectively our findings indicate that preclinical kinome and transcriptome profiling may predict the cardiotoxicity of novel kinase inhibitors, and suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription/epidermal growth factor receptor inhibition for cancer treatment.
Prolyl 4‐Hydroxylase Domain Protein 3 Overexpression Improved Obstructive Sleep Apnea—Induced Cardiac Perivascular Fibrosis Partially by Suppressing Endothelial‐to‐Mesenchymal Transition
Authors: Zhang Guang‐hao , Yu Fu‐chao , Li Yang , Wei Qin , Song Song‐song , Zhou Fang‐ping , Tong Jia‐yi 
Published: October 2017

Background
Intermittent hypoxia (IH) induced by obstructive sleep apnea is the key factor involved in cardiovascular fibrosis. Under persistent hypoxia condition, endothelial cells respond by endothelial‐to‐mesenchymal transition (EndMT), which is associated with cardiovascular fibrosis. Prolyl 4‐hydroxylase domain protein 3 (PHD3) is a cellular oxygen sensor and its expression increased in hypoxia. However, its role in obstructive sleep apnea–induced EndMT and cardiovascular fibrosis is still uncertain. We investigated the potential mechanism of obstructive sleep apnea–induced cardiac perivascular fibrosis and the role of PHD3 in it.

Methods and Results
In vivo, C56BL/6 mice were exposed to IH for 12 weeks. PHD3 expression was changed by lentivirus‐mediated short‐hairpin PHD3 and lentivirus carrying PHD3 cDNA. EndMT related protein levels, histological and functional parameters were detected after 12 weeks. In vitro, human umbilical vein endothelial cells were treated with IH/short‐hairpin PHD3/lentivirus carrying PHD3 cDNA to explore the mechanism of PHD3 in altered function of human umbilical vein endothelial cells. We found that chronic intermittent hypoxia increase PHD3 expression and EndMT. In vivo, IH accelerate cardiac dysfunction and aggravate collagen deposition via the process of EndMT. And, when PHD3 were overexpressed, cardiac dysfunction and collagen excessive deposition were improved. In vitro, IH induced EndMT, which endow human umbilical vein endothelial cells spindle morphology and an enhanced ability to migration and collagen secretion. PHD3 overexpression in cultured human umbilical vein endothelial cells ameliorated IH–induced EndMT through inactivating hypoxia‐inducible factor 1 alpha and small mothers against decapentaplegic 2 and 3.

Conclusions
Obstructive sleep apnea–induced cardiac perivascular fibrosis is associated with EndMT, and PHD3 overexpression might be beneficial in the prevention of it by inhibiting EndMT. PHD3 overexpression might have therapeutic potential in the treatment of the disease.
Contrasting Contrastive Left-Dislocation Explications
Authors: den Dikken Marcel , Surányi Balázs 
Published: October 2017

AbstractOf the three logically possible approaches to contrastive left-dislocation (CLD) (base-generation cum deep anaphora; movement cum surface anaphora; elliptical clausal juxtaposition cum resumption), two are represented prominently in the recent literature. Ott’s (2014) account treats CLD uniformly in terms of clausal juxtaposition, the first clause being stripped down to its contrastive topic via an ellipsis operation said to be akin to sluicing. He argues that this analysis is superior to Grohmann’s (2003) approach, featuring movement within a single prolific domain and late spell-out of a resumptive element. Using data mainly from Hungarian and Dutch, we reveal problems for Ott’s biclausal account that undermine its apparent conceptual appeal and compromise its descriptive accuracy. We show that the ellipsis operation required is sui generis, that the approach fails to assimilate the crosslinguistic variation attested in the availability of multiple CLD to known cases of parametric variation in the left periphery, and that it undergenerates in several empirical domains, including P-stranding and “floated” arguments. Grohmann’s movement-cum-surface-anaphora analysis as it stands also cannot handle all these data, but it can be fixed to fit the facts. For Ott’s analysis, no patches seem available. Some further empirical properties of CLD appear underivable from either of these approaches. For these, the base-generation-cum-deep-anaphora analysis can be considered.
Models for Jewish Bible Theologies
Authors: Kalimi Isaac 
Published: October 2017

Abstract
Against continuing attempts to define “Old Testament theology” or “biblical theology” in exclusively Christian terms, and in light of ongoing methodological diversity and confusion between proponents of Jewish biblical theology, this article suggests three models for the latter. The first one investigates the theologies of the different parts of the Hebrew Bible on their own, diachronically, without interference from later theology or practice. The second one focuses synchronically on the form of the Hebrew Bible as canonized, and is as objective as this basic biblical text allows. The third one is explicitly subjective and confessional, reading the Hebrew Bible in relation to the larger canon of Judaism, that is, the Oral Torah (= talmudic and midrashic literature). All three models have a legitimate place in the construction of a genuinely Jewish biblical theology, but they must not be confused. They all begin with different presuppositions and pursue different goals, but when properly distinguished, they can also complement one another, each exploring different aspects of the theology of the Jewish Bible.
Christological Monotheism
Authors: Gaston Thomas , Perry Andrew 
Published: October 2017

Abstract
Richard Bauckham and N. T. Wright have proposed that in 1 Corinthians 8:6 Paul consciously expands upon the Shema, and would be understood to be doing so by his intended readers, and thus Paul includes Jesus within the unique divine identity. In this paper we question this proposal on several grounds. We argue that it is unlikely that 1 Corinthians 8:6 would be read as an expansion of the Shema. We demonstrate that κύριος in this context is unlikely to stand for Yhwh. We also raise doubts over the concept of “inclusion” within the divine identity. We conclude that 1 Corinthians 8:6 is better understood as an expression of monotheism simpliciter.
Gender differences in the prevalence of nonalcoholic fatty liver disease in the Northeast of Thailand: A population-based cross-sectional study
Authors: Summart Ueamporn , Thinkhamrop Bandit , Chamadol Nittaya , Khuntikeo Narong , Songthamwat Metha , Kim Christina Sunyoung 
Published: October 2017

Background. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. A large number of studies have strongly described larger proportions of men being afflicted with NAFLD than women; however, recent studies investigating the role of gender and NAFLD have exposed the contrary. Methods. This cross-sectional study utilized data from the baseline survey of an ongoing cohort study called the Cholangiocarcinoma Screening and Care Program (CASCAP), conducted in the northeastern region of Thailand between March 2013 and September 2015. Information regarding socio-demographic, including gender, was collected using a standardized self-administered questionnaire. NAFLD was diagnosed with ultrasonography by board-certified radiologists. A binomial regression was used for estimating the prevalence differences, odds ratios (OR) and the 95% confidence intervals (CI) of NAFLD between men and women. Results. A total of 34,709 participants (27,073 females and 7,636 males) were recruited. The prevalence of NAFLD in women was 22.9% (95% CI: 22.5 to 23.5), whereas it was only 18.3% (95% CI: 17.4 to 19.2) in men. After adjusting for age and presence of diabetes mellitus and other underlying diseases, the prevalence was significantly higher in women, with adjusted prevalence difference of 4.2% (95% CI: 3.2 to 5.2) and adjusted OR of 1.3 (95% CI: 1.2 to 1.4). Women had a higher prevalence of NAFLD than men in all age groups and the largest difference was found in those aged 56-60 years (prevalence = 27.4% versus 21.2%; adjusted prevalence difference = 9.4%; 95% CI: 7.9 to 10.9; adjusted OR = 1.8; 95% CI: 1.8 to 2.0). Conclusion. NAFLD is more likely to affect women more than men, in particular, among the population 56-60 years of age, which is the post-menopausal transitional period. Therefore, post-menopausal women should be the target for interventions or further investigation for NAFLD.
The surgical treatment of acromioclavicular joint injuries
Authors: Boffano Michele , Mortera Stefano , Wafa Hazem , Piana Raimondo 
Published: October 2017

Acromioclavicular joint (ACJ) injuries are common, but their incidence is probably underestimated. As the treatment of some sub-types is still debated, we reviewed the available literature to obtain an overview of current management. We analysed the literature using the PubMed search engine. There is consensus on the treatment of Rockwood type I and type II lesions and for high-grade injuries of types IV, V and VI. The treatment of type III injuries remains controversial, as none of the studies has proven a significant benefit of one procedure when compared with another. Several approaches can be considered in reaching a valid solution for treating ACJ lesions. The final outcome is affected by both vertical and horizontal post-operative ACJ stability. Synthetic devices, positioned using early open or arthroscopic procedures, are the main choice for young people. Type III injuries should be managed surgically only in cases with high-demand sporting or working activities. Cite this article: EFORT Open Rev 2017;2:432–437. DOI: 10.1302/2058-5241.2.160085.
Increasing the Regional Economic Groth through Small and Medium Entreprises
Authors: Riwayati Hedwigis Esti 
Published: October 2017

This study aimed to analyze the influence of regional revenue, capital expenditures, labor and small and medium enterprises towards the regional economic growth in the Regencies in Sulawesi Island. This study uses a quantitative approach with secondary data obtained from the Central Statistics Agency. Based on the results of the panel data analysis using EViews 8.0 program processing tools, the results indicate that in partial local revenue, capital expenditures, labor, small and medium enterprises have significant positive effect on regional economic growth in the Regency/City of the island of Sulawesi. Another Â conclusion Â ofÂ the Â results Â in Â this Â research Â are Â feasible Â estimated regression model is used to explain the economic growth of the Regency/City of the island of Sulawesi.
ANALISIS FORMAL DAN INFORMAL FISIK PERMUKIMAN TEPIAN SUNGAI KAHAYAN KOTA PALANGKA RAYA
Authors: Hamidah Noor , Rijanta R , Setiawan Bakti , Marfai Muh. Aris 
Published: October 2017

Most of the settlement in Indonesia are located along big river. Kampung Pahandut is one of riverside settlement, thatis to observe in this research. Kampung Pahandut is a first settlement before growth to urban area. Kampung Pahandut is a source of life and ease to access of transport between regions. Research of settlement integration is one of alternative to solve of settlement problem in Indonesia. Settlement consist of: (1) nature; (2) shell/house; (3) network; (4) man; and (5) community. This research only focus on analysis of physical integration (1) nature; (2) shell/house; and (3) network especially natural settlement with the unique of riverside architecture. The objective of this research was to explore the pattern of settlements as an adaptation to the physical environment riverside area and to analyses the physical, economic and social apart of integration of urban riverside settlement. Research method used a combination (mix-used method) based on field observation and quesioner with 50 sample representated on one villages of Pahandut. The results showed there are threevariables that affect to riverside settlement, namely: (1) nature; (2) settlement; and (3) network.. The three variable of the settlement pattern support settlements in those areas riverside towards sustainable development through to riverside area.
Microstructure and Plastic Properties of Mg-Li Alloys Smelted in Vacuum Induction Furnaces after Hot Working
Authors: Hadasik E. , Kuc D. , Mikuszewski T. , Schindler I. 
Published: October 2017

AbstractThe paper analyses the characteristics of plasticity and microstructure of magnesium alloys with lithium meant for hot plastic working with different lithium content. The alloys were prepared in conditions of vacuum smelting. Achieved ingots were subject to hot extrusion. Tests on Gleeble simulator were conducted to assess the susceptibility of tested alloys to plastic forming in conditions of hot plastic working. For tested alloy the activation energy was marked for hot plastic deformation and plasticity characteristics in function of Zener-Hollomon parameter. After the analysis of the influence of temperature on the deformability of tested alloys it was stated that the alloy containing 8%Li (LAZ831) has better susceptibility to plastic treatment than alloy containing 4%Li (LAZ431), but higher than in case of classic magnesium alloys - AZ31.
Control over the Biological Synthesis of Ag Nanoparticles by Selection of the Specific Algal Species
Authors: Sedlakova-Kadukova J. , Velgosova O. , Vosatka M. , Lukavsky J. , Dodd J. , Willner J. , Fornalczyk A. 
Published: October 2017

AbstractThe application of green synthesis in the nano-science and technology is of great importance in the area of the preparation of various materials. In this work, three selected algal species Parachlorella kessleri, Dictyosphaerium chlorelloides and Desmodesmus quadricauda were successfully used for the preparation of silver nanoparticles (AgNPs). Presence of AgNPs was confirmed by UV-vis spectroscopy and transmission electron microscopy. AgNPs produced by P. kessleri had narrow size distribution and average sizes of 7.6 nm. However, nanoparticle production lasted for long time. Nanoparticle formation by D. chlorelloides was the fastest, although, their average sizes were 23.4 nm with broad size distribution. Nanoparticles produced by D. quadricauda had average sizes 23.9 nm but they were the least stable, aggregated and precipitated from solutions within 3 days. These results confirmed that the size distribution and mean diameter of the nanoparticles, crucial for various applications, can be controlled by the organism selection.
3D Model Studies on the Effect of Bed and Powder Type Upon Radial Static Pressure and Powder Distribution in Metallurgical Shaft Furnaces
Authors: Panic B. 
Published: October 2017

AbstractThe flow of gases in metallurgical shaft furnaces has a decisive influence on the course and process efficiency. Radial changes in porosity of the bed cause uneven flow of gas along the radius of the reactor, which sometimes is deliberate and intentional. However, holdup of solid particles in descending packed beds of metallurgical shaft furnaces can lead to unintentional changes in porosity of the bed along the radial reactor. Unintentional changes in porosity often disrupt the flow of gas causing poor performance of the furnace. Such disruptions of flow may occur in the blast furnace due to high level of powder content in gas caused by large amount of coal dust/powder insufflated as fuel substitute. The paper describes the model test results of radial distribution of static pressure and powder hold up within metallurgical reactor. The measurements were carried out with the use of 3D physical model of two-phase flow gas-powder in the moving (descending) packed bed. Sinter or blast furnace pellets were used as packed bed while carbon powder or iron powder were used as the powder. Wide diversity within both static pressure distribution and powder distribution along the radius of the reactor were observed once the change in the type of powder occurred.
Physical Modelling of Tundish Slag Entrainment under Various Technological Conditions
Authors: Michalek K. , Gryc K. , Socha L. , Tkadlečková M. , Saternus M. , Pieprzyca J. , Merder T. , Pindor L. 
Published: October 2017

AbstractThis paper deals with the issue of physical modelling of vortexes creation and tundish slag entrainment over the mouth of the nozzle into the individual casting strands. Proper physical model is equivalent to the operational continuous casting machine No. 2 in TŘINECKÉ ŽELEZÁRNY, a.s. Physical modelling methodology and simulated operational conditions are shortly described. Physical modelling was used for the evaluation of current conditions of steel casting at the application of different impact pads in the tundish. Further, laboratory measurement on the physical model aiming the determination of exact critical periods of vortexes creation and study of the slag entrainment as a consequence of changes in surface level during the tundish refilling to standard level were realised. The obtained results were analysed and discussed.
Properties and Structure of Nanocrystalline Layers Obtained by Manual Metal Arc Welding (MMA)
Authors: Górka J. , Czupryński A. , Adamiak M. 
Published: October 2017

AbstractThe present paper is the result of the investigations of the properties and structure of nanocrystalline layers deposited from iron-based nanoalloy on steel S355N substrate by manual metal arc welding method (MMA). In the process of welding a 100 A current intensity was used with desiccation preheating at 80°C while maintaining the interpass temperature at range of 200°C. The resultant deposit welds were subjected to macro and microscopic metallographic examination, X-ray phase analyses and crystallite size was analyzed by X-ray diffractometry (XRD), additionally EDX chemical composition analysis of precipitates during scanning electron microscopy was performed. Working properties of the obtained nanocrystalline deposit welds were evaluated based on hardness and metal-to-mineral abrasive wear. The results of the deposit welds working properties measurements were compared with the properties of wear resistant steel HARDOX 400 type used as the reference material.
Electrorefining of High Carbon Ferromanganese in Molten Salts to Produce Pure Ferromanganese
Authors: Xiao S. J. , Liu W. , Gao L. , Zhang J. 
Published: October 2017

AbstractHigh carbon ferromanganese is used as a starting material to prepare pure ferromanganese by electrorefining in molten salts. High carbon ferromanganese was applied as the anode, molybdenum was the cathode and Ag/AgCl was the reference electrode. The anodic dissolution was investigated by linear polarization in molten NaCl-KCl system. Then potentiostatic electrolysis was carried out to produce pure ferromanganese from high carbon ferromanganese. The cathodic product was determined to be a mixture of manganese and iron by x-ray diffraction (XRD). The content of carbon in the product was analyzed by carbon and sulfur analyzer. The post-electrolysis anode was characterized by scanning electron microscope (SEM). The mechanism of the anode dissolution and the distribution of the main impurity of carbon and silicon after electrolysis were discussed.
Factors Affecting the Wear Resistance of Forging Tools
Authors: Zwierzchowski M. 
Published: October 2017

AbstractThe durability of forging tools is a function of many variables: tool heat treatment, surface quality, temperature, pressure, number of forgings, diffusion layers (nitriding) and many others. The objective of study was to analyze and compare the working conditions of forging tools. For the analysis of selected flat surfaces of tools. Analyzed forging dies subjected to normal use. Presented results of laboratory tests . The effect of temperature and time on the properties of the surface layer of forging tools. The results were compared with the literature data. This article shows the results of microhardness tests for forging dies which have forged the corresponding number of forgings. The results of laboratory studies on microhardness of hot working steel 1.2344 in the furnace at various temperatures and time are also presented. The working conditions of the forging tools are very complex. The most often described in the literature are: thermal fatigue, abrasive wear, mechanical fatigue and cracks. The article discusses the effects of increased temperature on the surface properties of forging tools. Forging dies were made of hot work tool steel 1.2344. FEM modeling of changes in the surface layer should take into account changes in tool hardness as a function of time (number of forgings).
Behavior of Steel Branch Connections during Fatigue Loading
Authors: Sládek A. , Patek M. , Mičian M. 
Published: October 2017

AbstractFatigue behavior of the branch connection made of low-alloyed steel with yield stress of 355 MPa during low-cycle bending test is investigated in the article. Numerical prediction of the stress and strain distribution are described and experimentally verified by fatigue test of the branch connection sample. Experimental verification is based on low-cycle bending testing of the steel pipes welded by manual metal arc process and loaded by external force in the appropriate distance. Stresses and displacement of the samples induced by bending moment were measured by unidirectional strain gauges and displacement transducers. Samples were loaded in different testing levels according to required stress for 2.106 cycles. Increase of the stress value was applied until the crack formation and growth was observed. Results showed a high agreement of numerical and experimental results of stress and displacement.