bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Phase II Evaluation of Bevacizumab Versus Bevacizumab Plus Fosbretabulin in Recurrent Ovarian, Tubal, or Peritoneal Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study
Authors: Monk Bradley J. , Sill Michael W. , Walker Joan L. , Darus Christopher J. , Sutton Gregory , Tewari Krishnansu S. , Martin Lainie P. , Schilder Jeanne M. , Coleman Robert L. , Balkissoon Jai , Aghajanian Carol 
Published: May 2016

Purpose The vascular disrupting agent fosbretabulin tromethamine selectively targets pre-existing tumor vasculature, which causes vascular shutdown and leads to cancer cell death and necrosis. Antiangiogenesis agents such as bevacizumab, a humanized antivascular endothelial growth factor monoclonal antibody, might prevent revascularization during and after treatment with a vascular disrupting agent. Patients and Methods Patients with recurrent or persistent epithelial ovarian, tubal, or peritoneal carcinoma, measurable or detectable disease, and three or fewer prior regimens were randomly assigned to bevacizumab (15 mg/kg intravenously once every 3 weeks) or the combination of bevacizumab (15 mg/kg) plus fosbretabulin (60 mg/m2) intravenously once every 3 weeks until disease progression or toxicity. Randomization was stratified by disease status (measurable v nonmeasurable), prior bevacizumab, and platinum-free interval. The primary end point was progression-free survival (PFS). The study was designed with 80% power for a one-sided alternative at a 10% level of significance to detect a reduction in the hazard by 37.5%. Results The study enrolled 107 patients. Median PFS was 4.8 months for bevacizumab and 7.3 months for bevacizumab plus fosbretabulin (hazard ratio, 0.69; 90% two-sided CI, 0.47 to 1.00; one-sided P = .05). The proportion responding (overall response rate) to bevacizumab was 28.2% among 39 patients with measurable disease and 35.7% among 42 patients treated with the combination. The relative probability of responding was 1.27 (90% CI, 0.74 to 2.17; one-sided P = .24). Adverse events greater than grade 3 were more common in the combination regimen than in bevacizumab only for hypertension (35% v 20%). There was one grade 3 thromboembolic event in the combination arm and one intestinal fistula in the bevacizumab only arm. Conclusion On the basis of the PFS, overall response rate, and tolerability of these two antivascular therapies, further evaluation is warranted for this chemotherapy-free regimen. Fosbretabulin in combination with bevacizumab increases the risk of hypertension.
Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma
Authors: Goff Stephanie L. , Dudley Mark E. , Citrin Deborah E. , Somerville Robert P. , Wunderlich John R. , Danforth David N. , Zlott Daniel A. , Yang James C. , Sherry Richard M. , Kammula Udai S. , Klebanoff Christopher A. , Hughes Marybeth S. , Restifo Nicholas P. , Langhan Michelle M. , Shelton Thomas E. , Lu Lily , Kwong Mei Li M. , Ilyas Sadia , Klemen Nicholas D. , Payabyab Eden C. , Morton Kathleen E. , Toomey Mary Ann , Steinberg Seth M. , White Donald E. , Rosenberg Steven A. 
Published: May 2016

Purpose Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients with metastatic melanoma (52 of 93; 56%). Addition and intensification of total body irradiation (TBI) to the preparative lymphodepleting chemotherapy regimen in sequential trials improved objective partial and complete response (CR) rates. Here, we evaluated the importance of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a randomized fashion. Patients and Methods A total of 101 patients with metastatic melanoma, including 76 patients with M1c disease, were randomly assigned to receive nonmyeloablative chemotherapy with or without 1,200 cGy TBI before transfer of tumor-infiltrating lymphcytes. Primary end points were CR rate (as defined by Response Evaluation Criteria in Solid Tumors v1.0) and overall survival (OS). Clinical and laboratory data were analyzed for correlates of response. Results CR rates were 24% in both groups (12 of 50 v 12 of 51), and OS was also similar (median OS, 38.2 v 36.6 months; hazard ratio, 1.11; 95% CI, 0.65 to 1.91; P = .71). Thrombotic microangiopathy was an adverse event unique to the TBI arm and occurred in 13 of 48 treated patients. With a median potential follow-up of 40.9 months, only one of 24 patients who achieved a CR recurred. Conclusion Adoptive cell transfer can mediate durable complete regressions in 24% of patients with metastatic melanoma, with median survival > 3 years. Results were similar using chemotherapy preparative regimens with or without addition of TBI.
Endocrine Therapy for Hormone Receptor–Positive Metastatic Breast Cancer: American Society of Clinical Oncology Guideline
Authors: Rugo Hope S. , Rumble R. Bryan , Macrae Erin , Barton Debra L. , Connolly Hannah Klein , Dickler Maura N. , Fallowfield Lesley , Fowble Barbara , Ingle James N. , Jahanzeb Mohammad , Johnston Stephen R.D. , Korde Larissa A. , Khatcheressian James L. , Mehta Rita S. , Muss Hyman B. , Burstein Harold J. 
Published: May 2016

Purpose To develop recommendations about endocrine therapy for women with hormone receptor (HR) –positive metastatic breast cancer (MBC). Methods The American Society of Clinical Oncology convened an Expert Panel to conduct a systematic review of evidence from 2008 through 2015 to create recommendations informed by that evidence. Outcomes of interest included sequencing of hormonal agents, hormonal agents compared with chemotherapy, targeted biologic therapy, and treatment of premenopausal women. This guideline puts forth recommendations for endocrine therapy as treatment for women with HR-positive MBC. Recommendations Sequential hormone therapy is the preferential treatment for most women with HR-positive MBC. Except in cases of immediately life-threatening disease, hormone therapy, alone or in combination, should be used as initial treatment. Patients whose tumors express any level of hormone receptors should be offered hormone therapy. Treatment recommendations should be based on type of adjuvant treatment, disease-free interval, and organ function. Tumor markers should not be the sole criteria for determining tumor progression; use of additional biomarkers remains experimental. Assessment of menopausal status is critical; ovarian suppression or ablation should be included in premenopausal women. For postmenopausal women, aromatase inhibitors (AIs) are the preferred first-line endocrine therapy, with or without the cyclin-dependent kinase inhibitor palbociclib. As second-line therapy, fulvestrant should be administered at 500 mg with a loading schedule and may be administered with palbociclib. The mammalian target of rapamycin inhibitor everolimus may be administered with exemestane to postmenopausal women with MBC whose disease progresses while receiving nonsteroidal AIs. Among patients with HR-positive, human epidermal growth factor receptor 2–positive MBC, human epidermal growth factor receptor 2–targeted therapy plus an AI can be effective for those who are not chemotherapy candidates.
Zebrafish fin regeneration after cryoinjury-induced tissue damage
Authors: Chassot Bérénice , Pury David , Jaźwińska Anna 
Published: May 2016

ABSTRACTAlthough fin regeneration following an amputation procedure has been well characterized, little is known about the impact of prolonged tissue damage on the execution of the regenerative programme in the zebrafish appendages. To induce histolytic processes in the caudal fin, we developed a new cryolesion model that combines the detrimental effects of freezing/thawing and ischemia. In contrast to the common transection model, the damaged part of the fin was spontaneously shed within two days after cryoinjury. The remaining stump contained a distorted margin with a mixture of dead material and healthy cells that concomitantly induced two opposing processes of tissue debris degradation and cellular proliferation, respectively. Between two and seven days after cryoinjury, this reparative/proliferative phase was morphologically featured by displaced fragments of broken bones. A blastemal marker msxB was induced in the intact mesenchyme below the damaged stump margin. Live imaging of epithelial and osteoblastic transgenic reporter lines revealed that the tissue-specific regenerative programmes were initiated after the clearance of damaged material. Despite histolytic perturbation during the first week after cryoinjury, the fin regeneration resumed and was completed without further alteration in comparison to the simple amputation model. This model reveals the powerful ability of the zebrafish to restore the original appendage architecture after the extended histolysis of the stump.
Penerapan Metode Geolistrik Untuk Identifikasi Pola Penyebaran Zona Asin Di Bledug Kuwu, Grobogan, Jawa Tengah
Authors: D Darman , C Cari , D Darsono 
Published: May 2016

<span>Geoelectrical is one of geophysics methods which is used to investigate the early stage in <span>the shallow exploration. The research is conducted at Bledug Kuwu with Schlumberger <span>configuration method containing the two points of potential electrodes and the two points <span>of electrical current electrodes. The equipment used in this research are OYO model <span>2119C, GPS, meter roll, cable as current and potential electrodes. The purpose of the <span>research is to identify the spreading pattern of salty zone at Bledug Kuwu. The distribution <span>pattern of salty zone is characterized by thickness of 1.55 to 71.9 meters and range<br /><span>resistivity of 0.055 to 0.460 Ωm. At west of large Bledug, the salty zone is detected at the <span>depth of 5.0 to 10.0 meters and 30.0 to 50.0 meters. Meanwhile at east of large Bledug, the <span>salty zone is detected at the depth of 5.0 to 15.0 meters and 40.0 to 60.0 meters. The salty <span>zone spread from north to south at both west and east of large Bledug with resistivity of <span>0.05 to 0.50 Ωm at depth of 5.0 to 50.0 meters.</span></span></span></span></span></span></span></span></span></span></span><br /></span>
Attention on the edge: Ability to notice as a necessity in learning, teaching and survival
Authors: Fredriksen Biljana C. 
Published: May 2016

Abstract
This text reveals the process of my growing awareness about how attentiveness relates to learning, teaching and beyond. My research with young children uncovered their extraordinary abilities to be present and engaged in the moment. The children, my young co-researchers as well as my son, constantly challenged my understanding. The newly gained insights shaped my commitment to search for ways to cultivate mindfulness in my students. On the other hand, my experiences in research and teaching motivated explorations in my personal life where my selfawareness was truly put on test. Attentiveness is an embodied ability, nurtured in the arts where personal experiences matter, but often underestimated in school in general. Knowing that my students will be influencing new generations of children in the decades to come, I feel obligated to help them become attentive, responsible and affectionate teachers.
Can latitudes become forms? Unveiling purpose in higher education practice
Authors: Bastos Flávia M. C. 
Published: May 2016

Abstract
My praxis as teacher/scholar and the journey that led me here is marked by the political dimensions of education and visual art. For me, this relationship between education and politics is rooted in the Brazilian context of the mid-1960s, a time of great upheaval. Then and there, education and art provided strategies of resistance, with the arts articulating protest in veiled and codified language and transformative education methodologies providing tools to displace oligarchical assumptions about knowledge and society. This manuscript explores the motivations shaping my higher education work and its trajectory from my formative experiences in Brazil, and my professional training in the United States, to a global career.
A New Silver Complex with Ofloxacin – Preliminary Study
Authors: Rusu Aura , Popescu Gabriel-Cosmin , Imre Silvia , Ion Valentin , Vancea Szende , Grama Anda-Lavinia , Kelemen Hajnal , Hancu Gabriel 
Published: May 2016

Abstract

Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin.

Methods: To achieve our goals several spectroscopic methods (ultraviolet spectrophotometry, mass spectrometry, and Fourier transform infrared spectroscopy) and thermal methods (differential scanning calorimetry and thermogravimetric analysis) were used in order to elucidate the chemical structure of the complex.

Results: Using mass spectrometry we established the stoichiometric ratio silver:ofloxacin as 1:2. Experimental data suggest a particular coordination for ofloxacin, as a monodentate ligand, in the formation of a complex with silver, through the nitrogen atom from the methyl-piperazine cycle.

Conclusions: The obtained complex has a chemical structure likely [Ag(Ofloxacin)2]NO3, requiring evaluation through other physico-chemical methods.
Prevalence of Depression, Anxiety and Cognitive Impairment in Patients with Type 2 Diabetes from the Central Part of Romania
Authors: Cernea Simona , Zoltai Cristian , Berbecilă Daniela , Şular Floredana-Laura 
Published: May 2016

Abstract

Objective: The aim of this study was to assess the prevalence of depression, anxiety and cognitive impairment in patients with type 2 diabetes (T2D).

Material and methods: We conducted a cross-sectional study in patients with T2D. Depression and anxiety were assessed by questionnaires (PHQ-9, CES-D and GAD-7 respectively), cognitive function by the MoCA test. Additionally, 503 patients’ clinic charts were separately analyzed in order to compare the data recorded in the charts with that resulted from the active assessment.

Results: In the screening study 216 subjects with T2D were included (62.2 ± 7.8 years old). 34.3% of them had depression and 7.4% presented major depression. 44.9% of patients with T2D had anxiety (9.2% major anxiety) and this was highly correlated with depression (OR: 21.139, 95%CI: 9.767-45.751; p<0.0001). Women had significantly higher prevalence of depression and anxiety compared to men (42.1% vs. 21.7%; p: 0.0021 and 51.1% vs. 34.9%; p: 0.02), but severe depression was similar between genders (9.0% vs. 4.8%; p: 0.29). Significantly more patients had depression and anxiety than recorded in their charts (34.3% vs. 13.9% and 44.9% vs. 9.3%, respectively; p<0.0001 for both). 69.0% of T2D patients had mild, 6.0% had moderate and none had severe cognitive dysfunction, respectively. Significantly more patients with depression and anxiety had mild and moderate cognitive impairment (p: 0.03 and p: 0.04, respectively).

Conclusions: Patients with T2D had a high prevalence of comorbid depression, anxiety and cognitive impairment. Depression and anxiety were significantly more frequent in women. These conditions were under-evaluated and/or under-reported.
Data mining with Random Forests as a methodology for biomedical signal classification
Authors: Proniewska Klaudia 
Published: May 2016

Abstract
As the contribution of specific parameters is not known and significant intersubject variability is expected, a decision system allowing adaptation for subject and environment conditions has to be designed to evaluate biomedical signal classification. A decision support system has to be trained in its desirable functionality prior to being used for patient monitoring evaluation. This paper describes a decision system based on data mining with Random Forests, allowing the adaptation for subject and environment conditions. This methodology may lead to specific system scoring by an artificial intelligence-supported patient monitoring evaluation system, which may help find a way of making decisions concerning future treatment and have influence on the quality of patients’ life.
Light and temperature requirements for survival, growth and reproduction of the crustose coralline Lithophyllum stictaeforme from the Mediterranean Sea
Authors: Rodríguez-Prieto Conxi 
Published: May 2016

Abstract
Laboratory experiments were set up in order to assess light and temperature requirements for survival, growth and reproduction of specimens of Lithophyllum stictaeforme collected at 30–35 m depth in the NW Mediterranean. Three replicates were grown in a variety of regimes, with temperature varying from 10 to 26°C, photoperiod from 8:16 to 16:8 h light:dark, and irradiance from 5 to 75 μmol photons m-2 s-1. Other experiments were designed to imitate seasonal changes of temperature and photoperiod, and were maintained successively in temperature and photoperiod conditions of winter, spring, summer and autumn, and each set of conditions was combined with irradiances of 5, 10, 20, 50 and 75 μmol photons m-2 s-1. Survival of thalli depended on both irradiance and temperature, with a strong interaction between these factors. The longest survival of thalli (>5 years) was observed at 20 μmol photons m-2 s-1 combined with 10–12°C and an 8:16 h light:dark regime, while the lowest survival (<0.6 years) was observed at 75 μmol photons m-2 s-1 combined with 24–26°C and a 16:8 h light-dark regime. No marginal extension was observed in any of the culture conditions examined. The time required for reproductive structures to mature was always <1.5 years and was correlated with thallus survival; it was dependent on temperature/photoperiod and specimens living at higher temperatures released their reproductive cells earlier. In the culture conditions that simulated seasonal changes, conceptacles matured in autumn, in agreement with the behaviour of field specimens, except at 75 μmol photons m-2 s-1, when they matured earlier due to irradiance stress.
Plant extracts as “green” corrosion inhibitors for steel in sulphuric acid
Authors: Mo Shi , Luo Hong-Qun , Li Nian-Bing 
Published: May 2016

AbstractIn recent years, plant extracts have become the focus of corrosion inhibitor research due to their low toxicity, easy availability and economical preparation. This review presents most of the recent contributions made to the application of plant extracts as corrosion inhibitors for steel in sulphuric acid, as well as in both hydrochloric acid and sulphuric acid. The constituents, properties, adsorption modes and inhibition mechanisms of these natural products are discussed. Evaluation methods and the factors that influence the corrosion-inhibition efficiency of plant extracts are also summarised.
Symbolic Interaction Theory / Zur Theorie des symbolischen Interaktionismus
Authors: Peter W. 
Published: May 2016

Abstract
The status of Symbolic Interaction Theory as an explanatory system has rightly been called into question in recent descriptions, since symbolic interactionists have tended to stress empirical generalizations rather than the more explanatory aspects of the theory. In the present paper the theory is presented in a manner which permits both more systematic derivation of implications and more rigorous tests. Role taking is the principal construct in this formulation; the central propositions relate to the individual’s adaptive requirements and the adaptive consequences of role taking. Assuming that the present formulation is reasonably authentic, the writer argues that the theory has not been adequately developed and tested, leaving much of its promising potential untapped.
Soziologie ohne Soziologen? / Sociology without Sociologists
Authors: Matthes Joachim 
Published: May 2016

Abstract
Though there is a long and rich tradition of sociological thinking and research in Germany, a regular and scheduled teaching of this discipline has been established not earlier than in the fifties. In spite of a steadily growing number of students almost no efforts have been made to pay special regard to practical application of studies in sociology. Recent attempts to solve this problem are considerably hindered by a rapidly growing demand for contributions of sociological teaching to the curricula of other disciplines. The teaching capacity of sociology at West German universities ist heavily overloaded, and thus all the efforts to reshape sociological curricula are endangered as well as all the attempts to construct valuable contributions of sociology to the study of other disciplines. This precarious situation demands vigorous and effective measures. Discussions about the question who might take such measures are coinciding with deliberations as to the future structure of sociological curricula as well as to the teaching functions of sociology in the curricula of other disciplines. Special attention is drawn to the fact that social sciences and sociology are just - for the first time in Germany - introduced into the schools of secondary education, and it is criticized that there is no serious contribution to this development by academic sociology up to now.
Fragen zur Theorie der Statusinkonsistenz: Auf dem Wege zu einer Neuorientierung? / Status Inconsistency Theory: Towards a Reorientation?
Authors: Zimmermann Ekkart 
Published: May 2016

AbstractStatus inconsistency theory is criticized on the basis of some recent results. According to some of these studies additional variables should be added to the theory of status inconsistency, e.g. the mutual expectations which people have while interacting with one another, the subjective saliency of some of the status dimensions (and the respective combinations of status dimensions) as well as social visibility. Some questionable assumptions underlying the theory are being discussed. It turns out that numerous important assumptions are made which are considered to be plausible. In reality, however, they first have to be checked empirically.Other studies raise the question, whether a theory of status inconsistency is even necessary. Dimensions more relevant as to behavior are possibly covered in alternative theories. Also these theories may provide for more general statements so that status inconsistency theory appears to be only a sub-case.Among these theories discussed in the second half of the paper could be named: Role theory, reference group theory (with the sub-cases theory of relative deprivation and theory of cross pressures) as well as, above all, the theories of cognitive consistency.
Bedürfnisorientierungen und soziale Konflikte / Need-Orientations and Social Conflict
Authors: Hondrich Karl Otto 
Published: May 2016

Abstract
The terms of „need“ and „interest“ occupy a prominent place in contemporary social criticism and planning. As representatives of „person“ against „society“ their position is problematic since they are chronically influenced by changing social systems. Empirical research concerning the dynamics of differentiating need-orientations ought to go on within a theoretical concept of the relationship between personal needs and social structures. Structural functionalism, historical materialism, socialization theory, behavioral sociology, relative deprivation and symbolic interactionism are examined in this respect: A paradigm of systems analysis is proposed which interpretes exchange between material, social and personal systems by the medium of need-orientations. Need-orientations are seen as conflicts. Consequently, evolution of material and social systems is going on within personal systems by means of intrapersonal and social strategies of conflict resolution. Diagrams of the research project are intended to show how conflicts (need-orientations) and conflict solving strategies may be located empirically as differentiated variables and how those variables may be interconnected to form a body of hypotheses.