bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene networks show associations with seed region connectivity
Authors: Forest Marie , Iturria‐Medina Yasser , Goldman Jennifer S. , Kleinman Claudia L. , Lovato Amanda , Oros Klein Kathleen , Evans Alan , Ciampi Antonio , Labbe Aurélie , Greenwood Celia M.T. 
Published: March 2017

AbstractPrimary patterns in adult brain connectivity are established during development by coordinated networks of transiently expressed genes; however, neural networks remain malleable throughout life. The present study hypothesizes that structural connectivity from key seed regions may induce effects on their connected targets, which are reflected in gene expression at those targeted regions. To test this hypothesis, analyses were performed on data from two brains from the Allen Human Brain Atlas, for which both gene expression and DW‐MRI were available. Structural connectivity was estimated from the DW‐MRI data and an approach motivated by network topology, that is, weighted gene coexpression network analysis (WGCNA), was used to cluster genes with similar patterns of expression across the brain. Group exponential lasso models were then used to predict gene cluster expression summaries as a function of seed region structural connectivity patterns. In several gene clusters, brain regions located in the brain stem, diencephalon, and hippocampal formation were identified that have significant predictive power for these expression summaries. These connectivity‐associated clusters are enriched in genes associated with synaptic signaling and brain plasticity. Furthermore, using seed region based connectivity provides a novel perspective in understanding relationships between gene expression and connectivity. Hum Brain Mapp 38:3126–3140, 2017. © 2017 Wiley Periodicals, Inc.
The cerebellum shrinks faster than normal ageing in Alzheimer's disease but not in mild cognitive impairment
Authors: Tabatabaei‐Jafari Hossein , Walsh Erin , Shaw Marnie E. , Cherbuin Nicolas ,   for the Alzheimer's Disease Neuroimaging Initiative (ADNI)
Published: March 2017

AbstractBackgroundWhile acceleration in age‐related cerebral atrophy has been well documented in Alzheimer's disease, the cerebellar contributions to this effect have not been thoroughly investigated. Objective: This study investigated cerebellar volume and atrophy rate using magnetic resonance imaging in individuals with normal cognition (CN), mild cognitive impairment (MCI), and Alzheimer's disease (AD). Methods: Two hundred twenty‐nine CN, 398 MCI and 191 AD participants of stage I ADNI database with screening scans were evaluated for cerebellar volume. Of those, 758 individuals with two or more follow‐up scans were categorized into stable, converted, and reverted CN, MCI and AD and evaluated for cerebellar atrophy rate. Results: Cerebellar volume was 2.5% larger in CN than in those with AD but there were no differences between CN and MCI and MCI and AD in cross‐sectional analysis. Similarly, the atrophy rate was 49% larger in AD and 64% larger in MCI who converted to AD but no difference was detected between CN and MCI. There were no association between education and APOEe4 and cerebellar volume or cerebellar atrophy across the diagnostic groups. Conclusion: Cerebellar atrophy contributes to Alzheimer's clinical progression but mostly at the late stage of the disease. However, even in the late stage shrinkage rate is less than the average of the shrinkage in the cerebrum and is not associated with AD moderators. This suggests that cerebellar involvement is secondary to cerebral involvement and can be due to network connection spread regardless of the primary pathology. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc. Hum Brain Mapp 38:3141–3150, 2017. © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. Hum Brain Mapp 38:3141–3150, 2017. © 2017 Wiley Periodicals, Inc.
Rapid differentiating colorectal cancer and colorectal polyp using dried blood spot mass spectrometry metabolomic approach
Authors: Jing Yu , Wu Xue , Gao Peng , Fang Zhongze , Wu Jingjing , Wang Qingjun , Li Chen , Zhu Zhitu , Cao Yunfeng 
Published: March 2017

AbstractColorectal cancer (CRC) is the third leading causes of cancer mortality, and the early‐stage detection could significantly enhance survival rates. Cancer influences the important metabolic pathways and the changes in metabolite levels had been used in many studies as the potential biomarkers. This study is aimed at screening metabolite biomarkers with CRC diagnosis potentials. The direct infusion mass spectrometry (MS) metabolomic analysis based on dried blood spot was used to distinguish CRC from polyp. The target metabolites were composed of 23 amino acids and 26 acylcarnitines. The 21 metabolites in blood were selected via multivariate analysis. A regression model was established based on parameters C16, Arg, C4/C8, C5/C3, Val, Phe/Tyr, Ala, C4/C3. Tenfold cross validation (CV) method was used to test this model and showed sensitivity of 81.18% and specificity of 83.95%. The metabolomic analysis is a practicable method for CRC detection. The use of direct MS analysis in metabolite screening could be finished in several minutes and served as a higher‐throughput method to distinguish CRC and polyps. © 2017 IUBMB Life, 69(5):347–354, 2017
Decomposition of Graphs into (k,r)‐Fans and Single Edges
Authors: Hou Xinmin , Qiu Yu , Liu Boyuan 
Published: March 2017

AbstractLet be the largest integer such that, for all graphs G on n vertices, the edge set can be partitioned into at most parts, of which every part either is a single edge or forms a graph isomorphic to H. Pikhurko and Sousa conjectured that for and all sufficiently large n, where denotes the maximum number of edges of graphs on n vertices that do not contain H as a subgraph. A ‐fan is a graph on vertices consisting of k cliques of order r that intersect in exactly one common vertex. In this article, we verify Pikhurko and Sousa's conjecture for ‐fans. The result also generalizes a result of Liu and Sousa.
Synthesis, Characterization, and Energetic Properties of Alkaline and Alkaline Earth Salts of 5,5′‐bistetrazole‐1,1′‐diolate
Authors: Wang Xiao Jun , Su Qiang , Li Li Jie , Jin Shao Hua , Niu Hu , Chen Shu Sen , Shu Qing Hai 
Published: March 2017

5,5′‐Bistetrazole‐1,1′‐diolate‐based energetic salts from alkaline (Li+, K+, and Na+) and alkaline earth metal salts (Mg2+, Ca2+, and Ba2+) were synthesized in a simple, straightforward manner and were characterized by IR and NMR spectroscopy, and elemental analysis. Single‐crystal X‐ray diffraction of 4 salts (Li+, Na+, K+, and Mg2+) is given. The X‐ray structures show that in the title compounds, the metal atoms are bonded to the nitrogen and oxygen in the bistetrazole ring to form the sandwich structure. In addition, thermal stabilities of all title compounds were determined with differential thermal analysis‐thermal gravity analysis. All these new materials exhibit excellent thermal stabilities, high density, and excellent insensitivity to impact (h50 > 60 cm). Especially, the potassium salt is of interest as potential “green heat‐resistance explosive” with high density and high thermal stability as well as low sensitivity.
Synthesis of naproxen‐imprinted polymer using Pickering emulsion polymerization
Authors: Kujawska Małgorzata , Zhou Tongchang , Trochimczuk Andrzej W. , Ye Lei 
Published: March 2017

AbstractFor the last decades, molecular imprinting is developing intensively, especially in the case of the application of new imprinting techniques. In this work, for the first time, a Pickering emulsion polymerization was used to synthesize the S‐naproxen–imprinted polymer spheres following a noncovalent protocol. To enhance the knowledge about imprinting process using mentioned technique, thorough analysis of the synthesis process was performed. Optimization of polymerization conditions included the selection of functional monomer, cross‐linking agent, type of porogen, surfactant, and the choice of appropriate amount of the template and porogen. Prepared materials were characterized using scanning electron microscopy and nitrogen adsorption. To study the binding properties, the sorption studies, including adsorption isotherms and competitive binding, were performed. Investigation of the effect of the functional monomer on the selective recognition of S‐naproxen showed that the interactions between the template molecule and 4‐vinylpyridine resulted in the best recognizing ability. Moreover, the synthesis with application of ethylene glycol dimethacrylae as a cross‐linker, toluene as a porogen, and Tween 20 as an additional emulsion stabilizer gave the most desired result. The optimal ratio of the porogen to monomers mixture was 0.1, due to the fact that the increase of the porogen volume resulted in the significant increase of nonspecific uptake. In addition, the tenfold molar excess of functional monomer relative to the template turned out to be optimal. Subsequent binding studies demonstrated that the material synthesized using optimized polymerization conditions consists of imprinted sites that are sensitive for the S‐naproxen.
A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation
Authors: Braun Jürgen , Tzschätzsch Heiko , Körting Clara , Ariza de Schellenberger Angela , Jenderka Marika , Drießle Toni , Ledwig Michael , Sack Ingolf 
Published: March 2017

PurposeTo develop a method of compact tabletop magnetic resonance elastography (MRE) for rheological tests of tissue samples and to measure changes in viscoelastic powerlaw constants of liver and brain tissue during progressive fixation.MethodsA 10‐mm bore, 0.5‐T permanent‐magnet–based MRI system was equipped with a gradient‐amplifier–controlled piezo‐actuator and motion‐sensitive spin echo sequence for inducing and measuring harmonic shear vibrations in cylindrical samples. Shear modulus dispersion functions were acquired at 200–5700 Hz in animal tissues at different states of formalin fixation and fitted by the springpot powerlaw model to obtain shear modulus μ and powerlaw exponent α.ResultsIn a frequency range of 300–1500 Hz, unfixed liver tissue was softer and less dispersive than brain tissue with μ = 1.68 ± 0.17 kPa and α = 0.51 ± 0.06 versus μ = 2.60 ± 0.68 kPa and α = 0.68 ± 0.03. Twenty‐eight hours of formalin fixation yielded a 400‐fold increase in liver μ, 25‐fold increase in brain μ, and two‐fold reduction in α of both tissues.ConclusionCompact 0.5‐T MRE facilitates automated measurement of shear modulus dispersion in biological tissue at low costs. Formalin fixation changes the viscoelastic properties of tissues from viscous‐soft to elastic‐stiff more markedly in liver than brain. Magn Reson Med 79:470–478, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Acceleration of ASL‐based time‐resolved MR angiography by acquisition of control and labeled images in the same shot (ACTRESS)
Authors: Suzuki Yuriko , Fujima Noriyuki , Ogino Tetsuo , Meakin James Alastair , Suwa Akira , Sugimori Hiroyuki , Van Cauteren Marc , van Osch Matthias J. P. 
Published: March 2017

PurposeNoncontrast 4D‐MR‐angiography (MRA) using arterial spin labeling (ASL) is beneficial because high spatial and temporal resolution can be achieved. However, ASL requires acquisition of labeled and control images for each phase. The purpose of this study is to present a new accelerated 4D‐MRA approach that requires only a single control acquisition, achieving similar image quality in approximately half the scan time.MethodsIn a multi‐phase Look‐Locker sequence, the first phase was used as the control image and the labeling pulse was applied before the second phase. By acquiring the control and labeled images within a single Look‐Locker cycle, 4D‐MRA was generated in nearly half the scan time of conventional ASL. However, this approach potentially could be more sensitive to off‐resonance and magnetization transfer (MT) effects. To counter this, careful optimizations of the labeling pulse were performed by Bloch simulations. In in‐vivo studies arterial visualization was compared between the new and conventional ASL approaches.ResultsOptimization of the labeling pulse successfully minimized off‐resonance effects. Qualitative assessment showed that residual MT effects did not degrade visualization of the peripheral arteries.ConclusionThis study demonstrated that the proposed approach achieved similar image quality as conventional ASL‐MRA approaches in just over half the scan time. Magn Reson Med 79:224–233, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Coronary MR angiography using image‐based respiratory motion compensation with inline correction and fixed gating efficiency
Authors: Henningsson Markus , Smink Jouke , van Ensbergen Gerald , Botnar Rene 
Published: March 2017

PurposeThe purpose of this study was to evaluate a new inline motion compensation approach called image‐based navigation with Constant Respiratory efficiency UsIng Single End‐expiratory threshold (iNAV‐CRUISE) for coronary MR angiography (CMRA).MethodsThe CRUISE gating technique was combined with iNAV motion correction and implemented inline for motion‐compensated CMRA on a 1.5 Tesla scanner. The approach was compared to conventional diaphragmatic navigator gating (dNAVG) in 10 healthy subjects. The CMRA images were compared for vessel sharpness and visual score of the right coronary artery (RCA), left anterior descending artery (LAD), left circumflex, and scan time.ResultsThe scan time was similar between the methods (dNAVG: 6:32 ± 1:09 vs. iNAV‐CRUISE: 6:58 ± 0:17, P = not significant). However, the vessel sharpness of the RCA (dNAVG: 60.2 ± 10.1 vs. iNAV‐CRUISE: 71.8 ± 8.9, P = 0.001) and LAD (dNAVG: 58.0 ± 8.0 vs. iNAV‐CRUISE: 67.4 ± 7.1, P = 0.008) were significantly improved using iNAV‐CRUISE. The visual score of the RCA was higher using iNAV‐CRUISE compared to dNAVG (dNAVG: 3,4,3 vs. iNAV‐CRUISE: 4,4,3, P < 0.01).ConclusionThe iNAV‐CRUISE approach out‐performs the conventional respiratory motion compensation technique in healthy subjects. Although scan time was comparable, the image quality was improved using iNAV‐CRUISE. Magn Reson Med 79:416–422, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Acute fatigue, and perceptual responses to resistance exercise
Authors: Fisher James Peter , Farrow Joshua , Steele James 
Published: March 2017

ABSTRACTIntroductionDespite assumptions, there is an absence of research on acute fatigue responses to high‐ and low‐load and advanced technique resistance exercise.MethodsTrained males (n = 8; age 27.2 ± 7.4 years, height 180.0 ± 6.6 cm, weight: 86.6 ± 10.3 kg) were assessed for decrement in maximal voluntary isometric torque (MVIT) and perceived effort and discomfort after heavier load (HL; 80% MVIT), lighter load (LL; 30% MVIT), forced repetition (FR), and breakdown set (BD) training protocols.ResultsAnalyses revealed a significant reduction in MVIT (P < 0.05) with a significant between‐condition effect, and significant post‐hoc pairwise comparisons between LL and both HL (P = 0.044) and FR (P = 0.013). There were no significant between‐condition effects for effort or discomfort (P > 0.05).DiscussionFatigue as a decrement in force production appears to follow a more complex relationship than simply 100% minus the force requirements of the task relative to a maximal voluntary contraction. Muscle Nerve 56: E141–E146, 2017
Electromechanical response times in the knee muscles in young and old women
Authors: Szpala Agnieszka , Rutkowska‐Kucharska Alicja 
Published: March 2017

ABSTRACTIntroductionThe aim of the study was to compare electromechanical response times [total reaction time (TRT), pre‐motor time (PMT), and electromechanical delay] in the knee muscles in groups of young and older women during release of peak torque (PT).MethodsFifty women (1 group approximately 20 years of age and the other approximately 60 years of age) participated in the study. PT and electromyographic activity were measured for flexors and extensors of the right and left knee in static conditions in response to a visual stimulus.ResultsSignificantly longer TRTs (P = 0.05) and PMTs (P = 0.05) were found in the group of older women compared with the younger participants. Asymmetry was found between the older and the younger group of women in PT of knee flexors.DiscussionSignificantly longer TRT and PMT phases in the group of older women suggests a longer time for information processing in the central nervous system in older people. Muscle Nerve 56: E147–E153, 2017
Sputtered Zn(O,S) buffer layers for CIGS solar modules—from lab to pilot production
Authors: Wachau André , Schulte Jonas , Agoston Peter , Hübler Florian , Steigert Alexander , Klenk Reiner , Hergert Frank , Eschrich Heinz , Probst Volker 
Published: March 2017

AbstractSputtering of Zn(O,S) from ZnO/ZnS compound targets has been proven to be a promising buffer layer process for Cd‐free CIGS modules due to easy in‐line integration, low cost and high efficiency on lab scale. In this publication, we report on successful upscaling of the lab process to pilot production. A record aperture efficiency of 13.2% has been reached on a 50 × 120 cm2 sized module. Neither a non‐doped ZnO layer nor additional annealing steps are required. Moreover, this very reproducible process yields a standard deviation comparable with that of the CdS base line. In contrast to lab experiments, strong performance gain after light soaking has been observed. The light‐soak‐induced power increase depends on the preparation of the window layer. Accelerated aging tests show high stability of module power. This is confirmed by outdoor testing for 20 months. Copyright © 2017 John Wiley & Sons, Ltd.
Uncovering allostery and regulation in SAMHD1 through molecular dynamics simulations
Authors: Patra Kajwal Kumar , Bhattacharya Akash , Bhattacharya Swati 
Published: March 2017

ABSTRACTThe human sterile alpha motif and HD domain‐containing protein 1 (SAMHD1) is a retroviral restriction factor in myeloid cells and non‐cycling CD4+ T cells, a feature imputed to its phosphohydrolase activity—the enzyme depletes the cellular dNTP levels inhibiting reverse transcription. The functionally active form of SAMHD1 is an allosterically triggered tetramer which utilizes GTP‐Mg+2‐dNTP cross bridges to link and stabilize adjacent monomers. However, very little is known about how it assembles into a tetramer and how long the tetramer stays intact. In this computational study, we provide a molecular dynamics based analysis of the structural stability and allosteric site dynamics in SAMHD1. We have investigated the allosteric links which assemble and hold the tetramer together. We have also extended this analysis to a regulatory mutant of SAMHD1. Experimental studies have indicated that phosphorylation of T592 downregulates HIV‐1 restriction. A similar result is also achieved by a phosphomimetic mutation T592E. While a mechanistic understanding of the process is still elusive, the loss of structural integrity of the enzyme is conjectured to be the cause of the impaired dNTPase activity of the T592E mutant. MD simulations show that the T592E mutation causes slightly elevated local motions which remain confined to the short helix (residues 591‐595), which contains the phosphorylation site and do not cause long‐range destabilization of the SAMHD1 tetramer within the timeframe of the simulations. Thus, the regulatory mechanism of SAMHD1 is a more subtle mechanism than has been previously suspected. Proteins 2017; 85:1266–1275. © 2017 Wiley Periodicals, Inc.
A systematic review of the literature reveals trends and gaps in integrated pest management studies conducted in the United States
Authors: Young Stephen L 
Published: March 2017

AbstractIntegrated pest management (IPM) is a broad‐based approach for addressing pests that negatively affect human and environmental health and economic profitability. Weeds, insects and disease‐causing pathogens (diseases) are the pests most often associated with IPM. A systematic review, widely used in other scientific disciplines, was employed to determine the most commonly studied IPM topics and summarize the reasons for these trends and the gaps. In a field synopsis of the literature, 1679 relevant published papers were identified and categorized into one of the following five broad areas: IPM and organic (organic), climate change and pests (climate), rural and urban IPM (rural and urban), next‐generation education (education) and advanced production systems (technology). Papers were examined in greater detail for at least one of the three main pests in a systematic review. A majority (85%) of IPM papers have been in the area of rural and urban IPM, primarily addressing agriculture (78%). Professionals, landowners and the general public were the focus of a majority (95%) of IPM papers on education. Technology is an increasing area of focus in the literature. Over the past 40 years, IPM papers have primarily (75%) addressed insects and been limited mostly to rural and urban settings. Climate change, technology and education specific to pest management studies are increasingly being published and will help broaden the focus that could result in increased adoption and development of IPM. © 2017 Society of Chemical Industry
Vectorisation of agrochemicals via amino acid carriers: influence of the spacer arm structure on the phloem mobility of phenylpyrrole conjugates in the Ricinus system
Authors: Marhadour Sophie , Wu Hanxiang , Yang Wen , Marivingt‐Mounir Cécile , Bonnemain Jean‐Louis , Chollet Jean‐François 
Published: March 2017

AbstractBACKGROUNDExcessive agrochemical use poses significant threats to environmental safety and human health. Reducing pesticide use without reducing yield is necessary for sustainable agriculture. Therefore, we developed a vectorisation strategy to enhance agrochemical delivery through plant amino acid carriers.RESULTSIn addition to a fenpiclonil conjugate recently described, three new amino acid conjugates were synthesised by coupling fenpiclonil to an l‐α‐amino acid. Phloem mobility of these conjugates, which exhibit different structures of the spacer arm introduced between fenpiclonil and the α‐amino acid function, was studied using the Ricinus model. Conjugate L‐14, which contains a triazole ring with the shortest amino acid chain, showed the best phloem systemicity among the four conjugates. By contrast, removing the triazole ring in the spacer arm did not improve systemicity. L‐14 exhibited phloem systemicity at all reported pH values (pH values from 5.0 to 6.5) of the foliar apoplast, while acidic derivatives of fenpiclonil were translocated only at pH values near 5.0.CONCLUSIONThe conjugates were recognised by a pH‐dependent transporter system and translocated at distance in the phloem. They exhibited a broader phloem systemicity than fenpiclonil acidic derivatives within the pH value range of the foliar apoplast. © 2017 Society of Chemical Industry