bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of transradial and transfemoral access in patients undergoing percutaneous coronary intervention for complex coronary lesions
Authors: Koifman Edward , Gaglia Michael A. , Escarcega Ricardo O. , Bernardo Nelson L. , Lager Robert A. , Gallino Robert A. , Ben‐Dor Itsik , Pichard Augusto D. , Baker Nevin C. , Lipinski Michael J. , Kiramijyan Sarkis , Negi Smita I. , Torguson Rebecca , Gai Jiaxiang , Suddath William O. , Satler Lowell F. , Waksman Ron 
Published: November 2016

ObjectiveComparison of transradial versus transfemoral access for complex percutaneous coronary intervention (PCI) with regard to both complications and long‐term outcomes.BackgroundRadial access has been shown to confer superior results in patients undergoing PCI, especially in patients with acute coronary syndromes. However, radial access has limitations of sheath and device size, which may increase procedure time and result in inferior outcomes.MethodsPatients undergoing PCI for complex lesions, defined as type C according the ACC/AHA classification system, were included in this study. Propensity matching was performed to adjust for differences in baseline characteristics. Transradial patients were then compared to transfemoral patients in regard to procedural, in‐hospital, and 6‐month outcomes.ResultsAmong 2142 patients with 2591 lesions treated, 1876 had femoral access and 267 had radial access. Radial access patients were more likely to be male (75% vs. 66%, P = 0.003) and less likely to present with acute myocardial infarction (27% vs. 42%, P < 0.001). Procedural characteristics demonstrated lower use of heparin in the femoral group (17% vs. 73%, P < 0.001) with similarly low use of glycoprotein inhibitors (5.6% vs. 3.4%, P = 0.14). Patients in the femoral group had higher rates of transfusions (3.7% vs. 0%, P = 0.004) and vascular complications (1.7% vs. 0%, P = 0.03). Following propensity matching, there was no difference in mid‐term outcomes between radial and femoral groups.ConclusionsIn patients with complex coronary lesions undergoing PCI, the radial approach demonstrates similar mid‐term outcomes as the femoral approach with a potentially lower rate of complications. © 2016 Wiley Periodicals, Inc.
Safety and efficacy of rotational atherectomy for the treatment of undilatable underexpanded stents implanted in calcific lesions
Authors: Ferri Luca A. , Jabbour Richard J. , Giannini Francesco , Benincasa Susanna , Ancona Marco , Regazzoli Damiano , Mangieri Antonio , Montorfano Matteo , Colombo Antonio , Latib Azeem 
Published: November 2016

ObjectivesCoronary stent underexpansion is a known risk factor for in‐stent restenosis and stent thrombosis. There are limited options once noncompliant balloons have failed to achieve optimal stent expansion. Excimer Laser Coronary Angioplasty with contrast medium injection is one possibility, but not readily available. Rotational atherectomy is an alternative, and has been described in case reports, but concerns exist regarding safety.MethodsAll consecutive patients undergoing rotational atherectomy for symptomatic in‐stent restenosis due to stent underexpansion resistant to noncompliant balloon postdilatation between January 2005 and December 2015 were analysed.ResultsA total of 16 patients underwent treatment during the study period and the procedure was successful in 14 cases (87.5%). The mean postprocedural minimal lumen diameter increased by 2.3 ± 0.8 mm and percentage diameter stenosis decreased from 82.17% ± 17.2% to 11.9% ± 9.1%. Intraprocedural complications occurred in two patients (burr entrapment successfully managed percutaneously and periprocedural myocardial infarction). At 1‐year follow‐up, the incidence of target lesion revascularisation was 13.3% (2 out of 15 patients), and one patient died from noncardiac death.ConclusionIn this small series of underexpanded stents, rotational atherectomy was an effective treatment for resistant stent underexpansion with acceptable outcomes. © 2016 Wiley Periodicals, Inc.
Coronary artery spatial distribution of chronic total occlusions: Insights from a large US registry
Authors: Garcia Santiago , Alraies M. Chadi , Karatasakis Aris , Yannopoulos Demetris , Karmpaliotis Dimitri , Alaswad Khaldoon , Jaffer Farouc A. , Yeh Robert W. , Patel Mitul P. , Bahadorani John , Karacsonyi Judit , Kalsaria Pratik , Danek Barbara , Banerjee Subhash , Brilakis Emmanouil S. 
Published: November 2016

ObjectiveTo assess the spatial distribution of chronic total occlusions (CTOs) within the coronary arteries and describe procedural strategies and outcomes during CTO percutaneous coronary intervention (PCI).BackgroundAcute occlusions due to plaque rupture tend to cluster within the proximal third of the coronary artery.MethodsWe examined the clinical and procedural characteristics of 1,348 patients according to lesion location within the coronary tree.ResultsA total of 1,369 lesions in 1,348 patients (mean age 66 ± 10 years, 85% male) were included. CTO PCI of proximal segments (n = 633, 46%) was more common than of mid (n = 557, 41%) and distal segments (n = 179, 13%). Patients undergoing CTO PCI of proximal segments were more likely to be smokers (P < 0.01), have prior coronary artery bypass graft surgery (P = 0.03) and lower ejection fraction (P = 0.04). CTOs occurring in proximal segments had longer length (P <0.01), proximal cap ambiguity (P < 0.01), and moderate/severe calcification (P < 0.01) compared to mid or distally located CTOs. Interventional collaterals were more often present in CTO PCI of proximal segments (64%, 53%, 56%, P < 0.01) consistent with the higher use of retrograde approach (47%, 33%, 37%, P < 0.01) relative to antegrade wire escalation (67%, 82%, 82%, P < 0.01). Procedural complexity was higher in CTO PCI of proximal segments (vs. mid and distal): contrast volume= 275 ml (200–375), 260 ml (200–350), 250 ml (175–350), P = 0.01; fluoroscopy time 53 minutes (32–83), 39 minutes (24–65), 40 minutes (22–72), P < 0.01. However, procedural success (87%, 90%, 85%, P = 0.1), technical success (89%, 91%, 88%, P = 0.24), and complications rates (2.8%, 2.5%, 2.2%, P = 0.88) were not different.ConclusionsThe most common target vessel location for CTO PCI is the proximal coronary segment. PCI of proximal occlusions is associated with adverse clinical and angiographic characteristics and often requires use of the retrograde approach, but can be accomplished with high procedural and technical success and low complication rates. © 2016 Wiley Periodicals, Inc.
Closure of very large PDA with pulmonary hypertension: Initial clinical case‐series with the new Occlutech® PDA occluder
Authors: Lehner Anja , Ulrich Sarah , Happel Christoph M. , Fischer Marcus , Kantzis Marinos , Schulze‐Neick Ingram , Haas Nikolaus A. 
Published: November 2016

ObjectiveWe report our recent experience with the new Occlutech® PDA Occluder, which seems suitable especially for closure of large patent ductus arteriosus (PDA) sizes with elevated pulmonary artery pressure (PAH).BackgroundAlthough considered a standard procedure in pediatric cath labs, closure of very large PDA (PDA/Aorta ratio > 0.5) and PAH remains a challenge.Methods/ResultsThe Occlutech® PDA occluder was used in eight children and adolescents (age 4–16, median 10.75 years), body weight from 14 to 54 kg (median 21 kg) with very large PDA and PAH: PDA diameter was 5–13 mm (median 10 mm); PAP/Aortic pressure ratio was 0.58–0.96. Sufficient occlusion of the PDA was documented by angiography and/or echocardiography in all cases. Four different device sizes were selected: Minimal diameter 6–14 mm (median 12 mm), length 6.3–16 mm (median 14 mm), aortic disc 13–24 mm (median 20 mm), size at the pulmonary end 8–18 mm (median 15 mm). A balloon test occlusion of the PDA was performed in five patients in order to evaulate the decline of pulmonary artery pressure or to delineate the exact anatomy of the PDA. Before release of the device, a careful “wiggle manoevre” was performed to assess the stability of the implanted device and to proof the inability to embolize to the aorta.ConclusionsWith the new Occlutech® PDA Occluder closure of very large PDAs and PAH is feasible and efficient. The wider pulmonary artery end of the Occlutech® PDA Occluder offers enhanced stability and reduces the risk of embolization. © 2016 Wiley Periodicals, Inc.
Feasibility and 1‐Year outcomes of subintimal revascularization with supera® stenting of long femoropopliteal occlusions in critical limb ischemia
Authors: Palena Luis M. , Diaz‐Sandoval Larry J. , Sultato Enrico , Brigato Cesare , Candeo Alessandro , Brocco Enrico , Manzi Marco 
Published: November 2016

BackgroundStent‐based revascularization of long femoro‐popliteal (FP) lesions has been mainly studied in claudicants and compromised by restenosis and stent fractures. The Supera® stent's biomimetic design allows enhanced fracture resistance. Data for Supera® stenting to treat long chronic total occlusions (CTOs) in patients with critical limb ischemia (CLI), are scarce.ObjectiveTo assess long‐term outcomes of subintimal revascularization with Supera® stenting, for long FP CTOs in patients with CLI.MethodsProspective, single‐center, single‐arm study of 34 consecutive CLI patients with FP TASC C and D CTOs, who underwent Supera® stenting after subintimal crossing. Primary efficacy endpoint was 1‐year patency and freedom from target lesion revascularization (TLR). Primary safety endpoint was the composite rate of freedom from death from any cause, major amputations, and TLR at a year. Secondary endpoints were stent integrity, clinical improvement, amputation free‐survival, quality of life, and cost‐efficiency.ResultsMean lesion length was 27.9 ± 10.2 cm. Acute technical success was 100%. Primary patency was 94.1%. Freedom from TLR was 97.1%. Limb salvage was 100%. Clinical improvement was observed in 100% of patients: TCPO2 increased from 12.7 ± 6.2 to 54.8 ± 8.4 mm Hg (p < 0,0001); and 100% of patients experienced a shift in Rutherford to class 0 (p < 0.0001). There were no stents fractures. Amputation free‐survival was 82.4%.ConclusionsSubintimal revascularization with Supera® stenting in CLI patients with long FP occlusions, is feasible and superior to validated efficacy performance goals. Larger multicenter studies are needed to validate the safety and efficacy of this novel alternative approach. © 2016 Wiley Periodicals, Inc.
Comprehensive Understanding of the Role of Brønsted and Lewis Acid Sites in Glucose Conversion into 5‐Hydromethylfurfural
Authors: Li Xiangcheng , Peng Kaihao , Liu Xiaohui , Xia Qineng , Wang Yanqin 
Published: November 2016

AbstractThe conversion of glucose and selectivity into 5‐hydromethylfurfural (HMF) were investigated over various silica–alumina composite (AlSiO) catalysts. The type, amount, and strength of the acidic sites were characterized by using NH3 temperature‐programmed desorption and FTIR spectroscopy and then correlated to the catalytic conversion of glucose into HMF to provide a quantitative relationship between the acidity and product selectivity. Lewis acid sites played an important role in glucose conversion, which can enhance the isomerization of glucose to fructose, whereas Brønsted acid sites had a detrimental effect. HMF selectivity had an almost linear relationship with the weak/total Lewis acid ratio (L*/L), indicating that weak Lewis acids could promote formation of HMF. The medium‐to‐strong Lewis acid sites can enhance the formation of undesired byproducts (levulinic acid, humins). The Brønsted to Lewis acid ratio (B/L) had an influence on the HMF selectivity; at similar L*/L ratios, volcano curves were obtained with the increase of the B/L ratio, but the influence was not as great as that of the L*/L ratio. Nb‐doped AlSiO catalysts were prepared and used in the conversion of glucose into HMF, which also confirmed the above findings. Under the optimized conditions, the HMF selectivity can reach 71 % at 92.6 % conversion of glucose with no clear decline after four catalytic cycles.
Towards Understanding Structure–Activity Relationships of Ni–Mo–W Sulfide Hydrotreating Catalysts
Authors: Hein Jennifer , Gutiérrez Oliver Y. , Albersberger Sylvia , Han Jinyi , Jentys Andreas , Lercher Johannes A. 
Published: November 2016

AbstractThe relation between activity and selectivity of a series of unsupported Ni–Mo, Ni–W, and Ni–Mo–W sulfides and the physicochemical properties of the sulfides and oxide precursors were explored. Bimetallic oxide precursors were a crystalline molybdate with layered structure ((NH4)HNi2(OH)2(MoO4)2) or a wolframite‐type nickel tungstate (NiWO4). Trimetallic precursors were mixed Mo–W–Ni phases appearing amorphous in XRD analysis, in which metal cations had environments similar to those in the bimetallic precursors. The XRD‐amorphous layered structure (obtained for a Ni–Mo–W precursor) led to the fastest sulfidation of Ni cations. The proximity of metal cations in precursors was retained after sulfidation, which lead to intralayer mixed Mo1−xWxS2 (in trimetallic materials) and varying concentrations of Ni at the perimeter of the Mo(W)S2 slabs. At MoS2 and WS2 edges, Ni has a square‐pyramidal coordination, which is significantly distorted at the Mo–W mixed edges. The catalyst with the lowest Mo/W–Ni coordination had the lowest rates for hydrodenitrogenation of o‐propylaniline and hydrodesulfurization of dibenzothiophene. Among the materials with significant Ni–Mo(W) coordinations, the most active sulfide catalyst at low temperatures was Ni–W with highly defective slabs, at high temperatures the Ni–Mo–W sulfide with the highest Ni concentration at the perimeter was the most active catalyst.
Hydrogen and Chemicals from Renewable Alcohols by Organometallic Electroreforming
Authors: Bellini Marco , Filippi Jonathan , Miller Hamish A. , Oberhauser Werner , Vizza Francesco , He Qinggang , Grützmacher Hansjorg 
Published: November 2016

AbstractThe selective and simultaneous production of hydrogen and chemicals from renewable alcohols was accomplished by using an electrolyzer, for which the anode electrocatalyst was an organometallic complex, [Rh(OTf)(trop2NH){P(4‐BuC6H4)3}] (trop2NH=bis(5H‐dibenzo[a,d]cyclohepten‐5‐yl)amine; −OTf=CF3SO3−), deposited on amorphous carbon and appropriately designed to promote the partial and selective oxidation of alcohols. The electrolyzer converted alcohols into industrially relevant chemicals and high‐purity hydrogen at high volume and with very low energy consumption.
9,10‐Diaminoanthracenes Revisited: The Influence of N‐Substituents on Their Electronic States
Authors: Uebe Masashi , Kato Tatsuhisa , Tanaka Kazuyoshi , Ito Akihiro 
Published: November 2016

AbstractThe electronic and molecular structures of 9,10‐diamino‐substituted anthracenes with different N‐substituents have been re‐examined. In particular, different N‐substituents influence both the electronic and molecular structures of the oxidized species of 9,10‐diaminoanthracenes. The anthrylene moiety of 9,10‐bis(N,N‐di(p‐anisyl)amino)anthracene retains its planarity during the course of two successive one‐electron oxidations, whereas 9,10‐bis(N,N‐dimethylamino)anthracene and 9,10‐bis(N‐p‐anisyl‐N‐methylamino)anthracene undergo a substantial structural change to a butterfly‐like structure through a two‐electron oxidation process. The structural changes observed for the oxidized states are ascribed to significant differences in the frontier molecular orbitals of the above‐mentioned three kinds of 9,10‐diaminoanthracenes due to different extents of mixing between the amine‐localized and anthrylene‐localized orbitals.
Alkyne Addition and Insertion Reactions of [(Me3Si)3Si]2Ge⋅PMe3
Authors: Walewska Małgorzata , Baumgartner Judith , Marschner Christoph , Albers Lena , Müller Thomas 
Published: November 2016

AbstractSilylated germylene–PMe3 adducts exchange their phosphane moiety smoothly for an N‐heterocyclic carbene or isocyanide species to form their respective base adducts. Reaction of the silylated germylene–PMe3 adducts with monosubstituted alkynes produce germylene adducts with the alkyne inserted into a Ge−Si bond. A computational study of this process provides evidence for the initial formation of a germirene, which rearranges to a vinylgermylene species. The thermodynamic driving force for this reaction is provided by subsequent adduct formation with PMe3. Reaction of the PMe3 adduct of bis[(trimethylsilyl)silyl]germylene with disubstituted alkynes leads to the formation of stable germirenes, which can be isomerized further to silagermetes.
Identification of Compounds that Selectively Stabilize Specific G‐Quadruplex Structures by Using a Thioflavin T‐Displacement Assay as a Tool
Authors: Jamroskovic Jan , Livendahl Madeleine , Eriksson Jonas , Chorell Erik , Sabouri Nasim 
Published: November 2016

AbstractSmall molecules are used in the G‐quadruplex (G4) research field in vivo and in vitro, and there are increasing demands for ligands that selectively stabilize different G4 structures. Thioflavin T (ThT) emits an enhanced fluorescence signal when binding to G4 structures. Herein, we show that ThT can be competitively displaced by the binding of small molecules to G4 structures and develop a ThT‐displacement high‐throughput screening assay to find novel and selective G4‐binding compounds. We screened approximately 28 000 compounds by using three different G4 structures and identified eight novel G4 binders. Analysis of the structural conformation and stability of the G4 structures in presence of these compounds demonstrated that the four compounds enhance the thermal stabilization of the structures without affecting their structural conformation. In addition, all four compounds also increased the G4‐structure block of DNA synthesis by Taq DNA polymerase. Also, two of these compounds showed selectivity between certain Schizosaccharomyces pombe G4 structures, thus suggesting that these compounds or their analogues can be used as selective tools for G4 DNA studies.
Stereoelectronic Chameleons: The Donor–Acceptor Dichotomy of Functional Groups
Authors: Vatsadze Sergey Z. , Loginova Yulia D. , dos Passos Gomes Gabriel , Alabugin Igor V. 
Published: November 2016

AbstractStereoelectronic factors account for the apparent reversal of donor–acceptor properties of a variety of functional groups by a simple change of their orientation in space. The new reactivity patterns that arise from spatial anisotropy are associated with chameleonic behavior of common organic functionalities.
Structure–Property Relationships in Click‐Derived Donor–Triazole–Acceptor Materials
Authors: Kautny Paul , Bader Dorian , Stöger Berthold , Reider Georg A. , Fröhlich Johannes , Lumpi Daniel 
Published: November 2016

AbstractTo shed light on intramolecular charge‐transfer phenomena in 1,2,3‐triazole‐linked materials, a series of 1,2,3‐triazole‐linked push–pull chromophores were prepared and studied experimentally and computationally. Investigated modifications include variation of donor and/or acceptor strength and linker moiety as well as regioisomers. Photophysical characterization of intramolecular charge‐transfer features revealed ambipolar behavior of the triazole linker, depending on the substitution position. Furthermore, non‐centrosymmetric materials were subjected to second‐harmonic generation measurements, which revealed the high nonlinear optical activity of this class of materials.
Layered Post‐Transition‐Metal Dichalcogenides (X−M−M−X) and Their Properties
Authors: Luxa Jan , Wang Yong , Sofer Zdenek , Pumera Martin 
Published: November 2016

AbstractAIIIBVI chalcogenides are an interesting group of layered semiconductors with several attractive properties, such as tunable band gaps and the formation of solid solutions. Unlike the typically sandwiched structure of transition‐metal dichalcogenides, AIIIBVI layered chalcogenides with hexagonal symmetry are stacked through the X−M−M−X motif, in which M is gallium and indium, and X is sulfur, selenium, and tellurium. In view of the inadequate study of the electrochemical properties and great interest in layered materials towards energy‐related research, herein the inherent electrochemistry of GaS, GaSe, GaTe, and InSe has been studied, as well as the exploration of their potential as hydrogen evolution reaction (HER) electrocatalysts. All four materials show redox peaks during cyclic voltammetry measurements. Furthermore, insights into catalysis of the HER are provided; these indicate the conductivity and number of active sites of the materials. All of these findings have important implications on their possible applications.
Boroquinol Complexes with Fused Extended Aromatic Backbones: Synthesis and Optical Properties
Authors: Elbert Sven M. , Wagner Philippe , Kanagasundaram Thines , Rominger Frank , Mastalerz Michael 
Published: November 2016

AbstractBoron‐based dyes are attractive synthetic targets due to their large variability of absorption and emission wavelengths. Through Pictet–Spengler cyclizations, followed by oxidation, π‐extended boroquinols have been synthesized. During optimization of the reaction conditions, an unusual dearylation has been found and mechanistically investigated. For two of the synthesized boroquinols, mechanochromic effects with bathochromic shifts up to 50 nm were found upon grinding.
The First Casbane Hydroperoxides EBC‐304 and EBC‐320 from the Australian Rainforest
Authors: Maslovskaya Lidiya A. , Savchenko Andrei I. , Gordon Victoria A. , Reddell Paul W. , Pierce Carly J. , Parsons Peter G. , Williams Craig M. 
Published: November 2016

AbstractInvestigation of the Australian rainforest plant Croton insularis led to isolation of the first casbane hydroperoxide diterpenes EBC‐304 and EBC‐320. Extensive DFT and electronic circular dichroism (ECD) calculations in combination with 2D NMR spectroscopy determined the absolute configurations. EBC‐304 and EBC‐320 both display significant cytotoxicity.
An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation
Authors: Kang Juhye , Lee Shin Jung C. , Nam Jung Seung , Lee Hyuck Jin , Kang Myeong‐Gyun , Korshavn Kyle J. , Kim Hyun‐Tak , Cho Jaeheung , Ramamoorthy Ayyalusamy , Rhee Hyun‐Woo , Kwon Tae‐Hyuk , Lim Mi Hee 
Published: November 2016

AbstractAggregates of amyloidogenic peptides are involved in the pathogenesis of several degenerative disorders. Herein, an iridium(III) complex, Ir‐1, is reported as a chemical tool for oxidizing amyloidogenic peptides upon photoactivation and subsequently modulating their aggregation pathways. Ir‐1 was rationally designed based on multiple characteristics, including 1) photoproperties leading to excitation by low‐energy radiation; 2) generation of reactive oxygen species responsible for peptide oxidation upon photoactivation under mild conditions; and 3) relatively easy incorporation of a ligand on the IrIII center for specific interactions with amyloidogenic peptides. Biochemical and biophysical investigations illuminate that the oxidation of representative amyloidogenic peptides (i.e., amyloid‐β, α‐synuclein, and human islet amyloid polypeptide) is promoted by light‐activated Ir‐1, which alters the conformations and aggregation pathways of the peptides. Additionally, their potential oxidation sites are identified as methionine, histidine, or tyrosine residues. Overall, our studies on Ir‐1 demonstrate the feasibility of devising metal complexes as chemical tools suitable for elucidating the nature of amyloidogenic peptides at the molecular level, as well as controlling their aggregation.