bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calibration-free quantitative elemental analysis of meteor plasma using reference laser-induced breakdown spectroscopy of meteorite samples
Authors: Ferus Martin , Koukal Jakub , Lenža Libor , Srba Jiří , Kubelík Petr , Laitl Vojtěch , Zanozina Ekaterina M. , Váňa Pavel , Kaiserová Tereza , Knížek Antonín , Rimmer Paul , Chatzitheodoridis Elias , Civiš Svatopluk 
Published: December 2017

Aims. We aim to analyse real-time Perseid and Leonid meteor spectra using a novel calibration-free (CF) method, which is usually applied in the laboratory for laser-induced breakdown spectroscopic (LIBS) chemical analysis.
Methods. Reference laser ablation spectra of specimens of chondritic meteorites were measured in situ simultaneously with a high-resolution laboratory echelle spectrograph and a spectral camera for meteor observation. Laboratory data were subsequently evaluated via the CF method and compared with real meteor emission spectra. Additionally, spectral features related to airglow plasma were compared with the spectra of laser-induced breakdown and electric discharge in the air.
Results. We show that this method can be applied in the evaluation of meteor spectral data observed in real time. Specifically, CF analysis can be used to determine the chemical composition of meteor plasma, which, in the case of the Perseid and Leonid meteors analysed in this study, corresponds to that of the C-group of chondrites.
Fibromyalgia Management with Homeopathy
Authors: Wandile Pranali 
Published: December 2017

AbstractFibromyalgia is one of the most common genetically inherited chronic affective spectrum disorders (ASD). Other ASD disorders are psychiatric and medical conditions such as irritable bowel syndrome (IBS), migraine, cataplexy—attention-deficit/hyperactivity disorder, bulimia nervosa, dysthymic disorder, generalised anxiety disorder, major depressive disorder (MDD), obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, premenstrual dysphoric disorder, rheumatoid arthritis, and social phobia. Apart from genetic factors, neuroendocrine, autonomic nervous system abnormalities, psychosocial variables and environmental stressors contribute in the pathophysiology of fibromyalgia and other associated disorders. In this article, we reviewed etiology, pathophysiology, maintaining and triggering factors, and various treatment options for fibromyalgia. Apart from the pain management, this condition can be managed by ancillary method of treatment. However, due to the genetic cause of the disease, there is very little to offer for its complete cure. Homeopathic miasmatic treatment focuses on the genetic cause of the disease for its complete annihilation while also providing various acute remedies for the temporary pain management. We reviewed homeopathy treatment management and various remedies, which have much to offer for this chronic condition while considering its genetic, triggering and maintaining factors.
An Electronic Referral Initiative to Facilitate Referral to a Chronic Disease Self-Management Program for Persons with Transient Ischemic Attack
Authors: Kessler Dorothy , Afkham Amir , Bourgoin Aline , Gocan Sophia , Sivakumar Brammiya , Windsor Mary , Liddy Clare 
Published: December 2017

Background Transient ischemic attack (TIA) is a strong predictor of subsequent stroke. Measures to decrease stroke incidence following TIA include medical management, risk factor optimization, and lifestyle modification. Best practice recommendations for stroke care promote individualized education on self-management across transitions from hospital to community settings. In the study region, patients with TIA are referred to the stroke prevention clinic where they receive rapid stroke assessment, risk factor management, education, and referral to risk reduction programs. Long-term management is typically the responsibility of primary care providers who may have limited resources for self-management support. Promotion of existing chronic disease self-management (CDSM) programs can complement this support.
Objective The objective of our project was to examine the feasibility and acceptability of an electronic referral system to an existing CDSM program to facilitate self-management support for persons with TIA.
Methods We performed a descriptive evaluation of a quality improvement project that involved development and implementation of a new electronic referral (eReferral) process. A partnership between the stroke prevention clinic and the regional Living Healthy CDSM program was developed alongside a clinical information system redesign implementing an eReferral system.
Results Referral to the Living Healthy CDSM program was offered to each patient at the stroke prevention clinic. Of 912 patients seen over a 6-month period, 62 (7%) agreed to be referred. Of these, 23 (37%) were registered or waitlisted.
Conclusion Formation of a partnership and implementation of the eReferral system facilitated referral to the Living Healthy CDSM program. Despite low referral and enrollment rates, the eReferral system provides one option to enhance self-management support for persons with TIA.
Who Is Safe to Extubate in the Neuroscience Intensive Care Unit?
Authors: Bösel Julian 
Published: December 2017

AbstractPatients admitted to the neuroscience intensive care unit (NICU) may have respiratory compromise from either central or peripheral neurological pathology, and may hence require intubation and mechanical ventilation for very diverse reasons. Liberation from invasive ventilation, that is, extubation, at the earliest possible time is a widely accepted principle in intensive care. For this, classic extubation criteria have been established in the general critical care setting, mainly targeting pulmonary function and cooperativeness of the patient. However, classic extubation criteria have failed to predict successful extubation in many studies on NICU patients, and extubation failure (EF) rates range between ∼20 and 40% in these. Not necessarily impaired consciousness, but neurological impairment of securing the airway and handling secretions (dysphagia, low pharyngeal muscle tone, weak cough, etc.) may be mainly responsible for this dilemma. Attempts have been made to identify predictors of EF or success, and to establish extubation scores for the NICU, but results have been partially controversial and the database is still weak. It is very important to have a stepwise protocol to approach extubation in the NICU patient and to be prepared for reintubation (at times in a difficult airway) and alternatives (such as tracheostomy). The particular challenges of safely extubating the NICU patient will be the focus of this review, including a suggestion for a standardized approach.
The Snake: A Slithery Patient, Difficult to Grasp
Authors: Heijnen Denise , Leupen Alex 
Published: December 2017

AbstractAlex Leupen has worked in the Homeopathic Doctors Centre in Utrecht, the Netherlands, since 1990. Nine colleagues work in this centre, including Jan Scholten. Alex is an experienced teacher (the Netherlands, Belgium and Germany) on the underlying systems in the plant families, animal kingdom, sarcodes, nosodes, fungi and the periodic table of the elements pertaining to homeopathic practice. In this column, he shares clinical tips.This edition of his column is written together with veterinary surgeon Denise Heijnen.
Magnesiummangel und Demenz
Authors: Kisters Klaus , Gröber Uwe 
Published: December 2017

ZUSAMMENFASSUNGDemenzerkrankungen schränken die Lebensqualität und -erwartung deutlich ein. Eine Zunahme der Inzidenz in den nächsten Jahren ist zu erwarten. In der Prophylaxe verschiedener Demenzformen hat Magnesium einen besonderen Stellenwert, erste Studien belegen die Wirksamkeit des Minerals auch in der Therapie. Pathophysiologisch liegt der Wirkung im Wesentlichen ein Kalzium/Magesiumantagonismus zugrunde.
Glutamin in der Krebstherapie
Authors: Meyer Alfons 
Published: December 2017

ZUSAMMENFASSUNGGlutamin ist die häufigste Aminosäure des Organismus und kommt in allen Geweben in hohen Konzentrationen vor. Im Gegensatz zur Glykolyse findet die Glutaminolyse nur unter aeroben Bedingungen in den Mitochondrien statt. Da Krebszellen ausschließlich Glukose zur Energiegewinnung nutzen und ihre Mitochondrien abgeschaltet bzw. defekt sind, ist eine Glutaminolyse kaum möglich. Die Wirkung von Glutamin auf das Tumorwachstum ist umstritten.
Medikamentöse Tumortherapie des metastasierten nicht kastrationsresistenten Prostatakarzinoms
Authors: Florian Jentzmik , Christian Fischer 
Published: December 2017

ZusammenfassungÜber Jahrzehnte galt die Androgendeprivation (ADT) als alleiniger Standard beim fortgeschrittenen metastasierten hormonnaiven
Prostatakarzinom in der Erstlinientherapie. 2016 wurde die Therapie durch die Kombination der Androgendeprivation mit dem Chemotherapeutikum
Docetaxel revolutioniert. Durch diese Chemohormontherapie konnte eine signifikante Verlängerung des progressionsfreien Überlebens und des
Gesamtüberlebens erreichet werden.Aktuell konnte in der STAMPEDE- und der LATITUDE-Studie ein signifikanter Zusatznutzen für eine Kombination von Abirateron plus Prednison
plus Androgendeprivation gezeigt werden. Sowohl das Gesamtüberleben, das progressionsfreie Überleben als auch die Zeit bis zum
radiologischen Progress konnten im Vergleich zur alleinigen Hormontherapie verbessert werden.Der Überlebensvorteil der Kombinationstherapie von ADT + Abirateron/Prednison ist mit dem der Chemohormontherapie gleichwertig. Aktuell kann
nach einer Stellungnahme des Arbeitskreises Onkologie (AKO) und der Arbeitsgemeinschaft urologische Onkologie (AUO) Patienten mit einem
hormonsensitiven metastasierten Prostatakarzinom alternativ zur Chemotherapie mit Docetaxel die Kombination aus ADT und Abirateron/Prednison
angeboten werden.Die Frage, ob Patienten mit metastasiertem nicht kastrationsresistenten Prostatakarzinom mehr von der Chemohormontherapie oder von der
Hormonkombinationstherapie mit Abirateron profitieren, kann zum aktuellen Zeitpunkt nicht abschließend geklärt werden. Aufgrund der besseren
Verträglichkeit kann die Kombinationstherapie ADT + Abirateron/Prednison jenen Patienten angeboten werden, die für eine Chemotherapie nicht
in Frage kommen. Ökonomisch zu berücksichtigen sind die beträchtlichen Mehrkosten durch höhere Kosten des Präparats und eine längere
Therapiedauer.
Vom Nutzen der Chirurgie und vom Nachteil der Narben
Authors: Von den Hoff Johannes , Ongkosuwito Edwin , Kuijpers-Jagtman Anne , Wagener Frank , Latif Abdul , Kuijpers Mette , Monroy PaolaL. 
Published: December 2017

ZusammenfassungDie chirurgische Versorgung von Patienten mit Lippen-Kiefer-Gaumenspalte hat die Rekonstruktion der anatomischen Verhältnisse, der Funktionalität und der Ästhetik des Gesichts zum Ziel. Bei Kindern mit vollständiger Spalte sind mind. 3 chirurgische Eingriffe erforderlich: Schließen der Lippenspalte, Schließen des harten und des weichen Gaumens sowie Füllen der Spalte im Alveolarfortsatz mit Knochenmaterial. Bei Patienten mit geschlossenen Spalten kommt es zur Störung des maxillofazialen Wachstums in allen 3 Raumebenen, die mit zunehmendem Alter immer deutlicher in Erscheinung treten. Beim Verschluss der Spalte im weichen Gaumen ist die Rekonstruktion der Muskulatur der entscheidende Faktor. Die häufigste Störung nach einer Rekonstruktion des weichen Gaumens ist die velopharyngeale Dysfunktion. Man ist bisher davon ausgegangen, dass die iatrogenen Folgen eines chirurgischen Eingriffs im Gaumen von der Wundkontraktion verursacht werden. Die Bildung von Narbengewebe sowie die damit einhergehende Verbindung des Narbengewebes mit dem Gaumenknochen und den parodontalen Fasern sind jedoch wahrscheinlich die wichtigsten Faktoren. Sie behindern das Oberkieferwachstum und führen zur Kippung von durchbrechenden Zähnen nach palatinal. Die gestörte Muskelregeneration und die Fibrose im weichen Gaumen behindern die funktionelle Rekonstruktion des weichen Gaumens. Neuartige Therapieansätze auf Grundlage von Tissue Engineering könnten neue Perspektiven für die Behandlung von Spaltpatienten eröffnen. Mithilfe von Scaffolds, einer Art Gerüste, die Wachstumsfaktoren kontrolliert freisetzen, lässt sich möglicherweise die Narbenbildung und die Muskelregeneration nach der chirurgischen Korrektur des weichen Gaumens beeinflussen. Zur Entwicklung solcher funktionalisierter Gerüste ist jedoch weitere Forschung erforderlich.
Folsäure
Authors: Gröber Uwe 
Published: December 2017

ZUSAMMENFASSUNGFolsäure erfüllt in seiner Wirkform Tetrahydrofolsäure essenzielle Funktionen in Zellwachstum und -teilung. Zur Verhinderung von Embryopathien durch Folsäuremangel in der Frühschwangerschaft wird die präkonzeptionelle Einnahme von Folsäure empfohlen. Im späteren Leben geht ein Mangel mit einer Risikoerhöhung für Demenz und kardiovaskuläre Komplikationen wie Schlaganfall einher. Diabetikern, Patienten mit kardiovaskulären Erkankungen und älteren Menschen sind Kontrollen des Homocysteinspiegels sowie ggf. Supplementierung von Folsäure und anderen B-Vitaminen anzuraten.
Editorial
Authors: Crismani Adriano 
Published: December 2017

Sehr geehrte Kolleginnen und Kollegen,es ist mir ein Vergnügen, Ihnen das 4. Heft 2017 der IOK präsentieren zu dürfen. Sie werden sicher einen oder sogar mehrere interessante Beiträge, von Autoren aus Deutschland, Österreich und Niederlande verfasst, finden. An dieser Stelle möchte ich mich aufrichtig bei den Verfassern für ihr Engagement und ihre Professionalität bedanken! Kurz zusammengefasst, werden in der vorliegenden Ausgabe unterschiedliche aktuelle Themen aus unserem Fach wie zum Beispiel Rezidiv und Stabilität nach transversaler Erweiterung, Erfolgskriterien für die skelettale Verankerung mit Minischrauben, neuartige Therapieansätze zur Behandlung von Spaltpatienten vorgestellt.
Patientenbeispiel: Schwere Hypomagnesiämie durch Venlafaxin
Authors: Gröber Uwe , Sprenger Jutta , Kisters Klaus 
Published: December 2017

ZUSAMMENFASSUNGDie 50-jährige Patientin wurde aufgrund ihrer Depression mit Venlafaxin in hoher Dosierung behandelt. Die laborchemische Kontrolle ergab eine schwere Hypomagnesiämie. Nach der Supplementierung stabilisierte sich der Zustand der Patientin rasch.Nach Recherchen der Autoren ist dies der erste internationale Fall, bei dem über eine Hypomagnesiämie unter Venlafaxin berichtet wird. Bisher sind bekannt eine Hyponatriämie und Hypokaliämie. Die Autoren empfehlen bei Venlafaxingabe die Kontrolle des Magnesiumstatus.
« La cena será en el restaurante La Rueda, que está en la calle San Miguel »
Authors: Azzopardi Sophie , Huyghe Richard 
Published: December 2017

Résumé
It is well known that the distribution of the Spanish verbs ser and estar, both equivalent of
be in English, depends upon the stage or individual level of the predicates. Ser and
estar are used to express respectively inherent or episodic properties. As a consequence, spatial location is
denoted by means of estar and not ser. There is an exception to this principle: event-denoting
nouns (ENs) combine only with ser in locative expressions. In this article, we further investigate the
construction of ser with ENs. By comparing the semantics of ENs with that of object-denoting nouns, we claim that
spatial location is treated as an inherent property of events because of the temporal features of ENs. Evidence for this
correlation can be found in the nonprototypical use of ENs as adverbials of place, and in the variations of spatial denotation
between ENs depending upon their variations of temporal denotation.
Final report of the SIM.QM-S8 supplementary comparison, trace metals in drinking water
Authors: Yang Lu , Nadeau Kenny , Pihillagawa Indu Gedara , Meija Juris , Mester Zoltan , Napoli Romina , Pérez Zambra Ramiro , Ferreira Elizabeth , Forigua Diego Alejandro Ahumada , Gamba Johanna Paola Abella 
Published: December 2017

After completing a supplementary comparison SIM.QM-S7, the National Metrology Institute of Colombia (NMIC) requested to National Research Council of Canada (NRC) a subsequent bilateral comparison, because INMC considered that its results in SIM.QM-S7 unrepresentative of its standards. In this context, NRC agreed to coordinate this bilateral comparison with the aim of demonstrating the measurement capabilities of trace elements in fresh water. Participants included NMIC and LATU. No measurement method was prescribed by the coordinating laboratory. Therefore, NMIs used measurement methods of their choice. However, the majority of NMIs/DIs used ICP-MS.
This SIM.QM-S8 Supplementary Comparison provides NMIs with the needed evidence for CMC claims for trace elements in fresh waters and similar matrices.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
eHistology image and annotation data from the Kaufman Atlas of Mouse Development
Authors: Baldock Richard A , Armit Chris 
Published: December 2017

Abstract
“The Atlas of Mouse Development” by Kaufman is a classic paper atlas that is the de facto standard for the definition of mouse embryo anatomy in the context of standard histological images. We have redigitized the original haematoxylin and eosin–stained tissue sections used for the book at high resolution and transferred the hand-drawn annotations to digital form. We have augmented the annotations with standard ontological assignments (EMAPA anatomy) and made the data freely available via an online viewer (eHistology) and from the University of Edinburgh DataShare archive. The dataset captures and preserves the definitive anatomical knowledge of the original atlas, provides a core image set for deeper community annotation and teaching, and delivers a unique high-quality set of high-resolution histological images through mammalian development for manual and automated analysis.
Prominence formation and ejection in cool stars
Authors: Villarreal D'Angelo Carolina , Jardine Moira , See Victor 
Published: December 2017

Abstract
The observational signatures of prominences have been detected in single and binary G and K type stars for many years now, but recently this has been extended to the M dwarf regime. Prominences carry away both mass and angular momentum when they are ejected and the impact of this mass on any orbiting planets may be important for the evolution of exoplanetary atmospheres. By means of the classification used in the massive star community, that involves knowledge of two parameters (the co-rotation and Alfvén radii, rK and rA), we have determined which cool stars could support prominences. From a model of mechanical support, we have determined that the prominence mass mp/M⋆ = (EM/EG)(r⋆/rK)2F where $E_MB_\star ^2r_\star ^3$ and $E_G = GM_\star ^2/r_\star$ are magnetic and gravitational energies and F is a geometric factor. Our calculated masses and ejection frequencies (typically 1016 − 1017 g and 0.4 d, respectively) are consistent with observations and are sufficient to ensure that an exoplanet orbiting in the habitable zone of an M dwarf could suffer frequent impacts.
Pediatric In-Hospital Cardiac Arrest Secondary to Acute Pulmonary Embolism
Authors: Morgan Ryan W. , Stinson Hannah R. , Wolfe Heather , Lindell Robert B. , Topjian Alexis A. , Nadkarni Vinay M. , Sutton Robert M. , Berg Robert A. , Kilbaugh Todd J. 
Published: December 2017

Objectives:
Pulmonary embolism is a rarely reported and potentially treatable cause of cardiac arrest in children and adolescents. The objective of this case series is to describe the course of five adolescent patients with in-hospital cardiac arrest secondary to pulmonary embolism.

Design:
Case series.

Setting:
Single, large academic children’s hospital.

Patients:
All patients under the age of 18 years (n = 5) who experienced an in-hospital cardiac arrest due to apparent pulmonary embolism from August 1, 2013, to July 31, 2017.

Interventions:
All five patients received systemic thrombolytic therapy (IV tissue plasminogen activator) during cardiac arrest or periarrest during ongoing resuscitation efforts.

Measurements and Main Results:
Five adolescent patients, 15–17 years old, were treated for pulmonary embolism–related cardiac arrests during the study period. These accounted for 6.3% of all children and 25% of adolescents (12–17 yr old) receiving at least 5 minutes of in-hospital cardiopulmonary resuscitation during the study period. All five had venous thromboembolism risk factors. Two patients had known, extensive venous thrombi at the time of cardiac arrest, and one was undergoing angiography at the time of arrest. The diagnoses of pulmonary embolism were based on clinical suspicion, bedside echocardiography (n = 4), and low end-tidal Co
2 levels relative to arterial Co
2 values (n = 5). IV tissue plasminogen activator was administered during cardiopulmonary resuscitation in three patients and after the return of spontaneous circulation, in the setting of severe hemodynamic instability, in the other two patients. Four of five patients were successfully resuscitated and survived to hospital discharge.

Conclusions:
Pulmonary embolism was recognized as the etiology of multiple adolescent cardiac arrests in this single-center series and may be more common than previously reported. Recognition, high-quality cardiopulmonary resuscitation, and treatment with thrombolytic therapy resulted in survival in four of five patients.
The Cumulative Partial Pressure of Arterial Oxygen Is Associated With Neurological Outcomes After Cardiac Arrest Treated With Targeted Temperature Management
Authors: Youn Chun Song , Park Kyu Nam , Kim Soo Hyun , Lee Byung Kook , Oh Sang Hoon , Jeung Kyung Woon , Choi Seung Pill 
Published: December 2017

Objective:
Hyperoxia could lead to a worse outcome after cardiac arrest. The aim of this study was to investigate the relationship between the cumulative partial pressure of arterial oxygen (Pao
2) and neurological outcomes after cardiac arrest treated with targeted temperature management.

Design:
Retrospective analysis of a prospective cohort.

Setting:
An academic tertiary care hospital.

Patients:
A total of 187 consecutive patients treated with targeted temperature management after cardiac arrest.

Interventions:
None.

Measurements and Main Results:
The area under the curve of Pao
2 for different cutoff values of hyperoxia (≥ 100, ≥ 150, ≥ 200, ≥ 250, and ≥ 300 mm Hg) with different time intervals (0–24, 0–6, and 6–24 hr after return of spontaneous circulation) was calculated for each patient using the trapezoidal method. The primary outcome was the neurologic outcome, as defined by the cerebral performance category, at 6 months after cardiac arrest. Of 187 subjects, 77 (41%) had a good neurologic outcome at 6 months after cardiac arrest. The median age was 54 (43–69) years, and 128 (68%) were male. The area under the curve of Pao
2 with cutoff values of greater than or equal to 200, greater than or equal to 250, and greater than or equal to 300 was higher in the poor outcome group at 0–6 and 0–24 hours. The adjusted odds ratios of area under the curve of Pao
2 greater than or equal to 200 mm Hg were 1.659 (95% CI, 1.194–2.305) for 0–24 hours after return of spontaneous circulation and 1.548 (95% CI, 1.086–2.208) for 0–6 hours after return of spontaneous circulation. With a higher cumulative exposure to oxygen tension, we found significant increasing trends in the adjusted odds ratio for poor neurologic outcomes.

Conclusion:
In a new method for Pao
2 analysis, cumulative exposure to hyperoxia was associated with neurologic outcomes in a dose-dependent manner. Greater attention to oxygen supply during the first 6 hours appears to be important for outcome after cardiac arrest.