bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flame‐Resistant Inorganic Films by Self‐Assembly of Clay Nanotubes and their Conversion to Geopolymer for CO2 Capture
Authors: Lo Bianco Alessandro , Calvino Martina Maria , Cavallaro Giuseppe , Lisuzzo Lorenzo , Pasbakhsh Pooria , Milioto Stefana , Lazzara Giuseppe , Lvov Yuri 
Published: October 2024

AbstractSelf‐assembling of very long natural clay nanotubes represents a powerful strategy to fabricate thermo‐stable inorganic thin films suitable for environmental applications. In this work, self‐standing films with variable thicknesses (from 60 to 300 µm) are prepared by the entanglement of 20–30 µm length Patch halloysite clay nanotubes (PT_Hal), which interconnect into fibrosus structures. The thickness of the films is crucial to confer specific properties like transparency, mechanical resistance, and water uptake. Despite its completely inorganic composition, the thickest nanoclay film possesses elasticity comparable with polymeric materials as evidenced by its Young's modulus (ca. 1710 MPa). All PT_Hal‐based films are fire resistant and stable under high temperature conditions preventing flame propagation. After their direct flame exposure, produced films do not show neither deterioration effects nor macroscopic alterations. PT_Hal films are employed as precursors for the development of functional materials by alkaline activation and thermal treatment, which generate highly porous geopolymers or ceramics with a compact morphology. Due to its high porosity, geopolymer can be promising for CO2 capture. As compared to the corresponding inorganic film, the CO2 adsorption efficiency is doubled for the halloysite geopolymeric materials highlighting their potential use as a sorbent.
Analyzing Paxlovid: Examining Its Properties, Characteristics, and Analytical and Bio‐Analytical Methods–A Comprehensive Review
Authors: Gandi Anusha , Dudi Pavan Kumar , Pantala Eswar Sandeep , Y Srinivasa Rao , Challa Gangu Naidu 
Published: October 2024

ABSTRACTPaxlovid, a novel antiviral medication developed by Pfizer, has attracted considerable attention as a coronavirus disease 2019 therapeutic since it may be effective in treating the severe acute respiratory syndrome coronavirus type 2‐caused disease. Paxlovid is known as a combination therapy since it includes two agents, Nirmatrelvir and Ritonavir, which both are involved in the viral replication process inhibition. A further discussion of the molecular structure, pharmacokinetics, and pharmacodynamics of both components will help comprehend Paxlovid's mechanism of impact and effectiveness. High‐performance and spectroscopic methods, including high‐performance liquid chromatography (HPLC), infrared, and ultraviolet‐visible spectroscopy have been among the methods employed for compound identification, quantification, and structural elucidation. Bioanalytical methods have also made a significant contribution to the evaluation of Paxlovid's pharmacokinetic parameters, bioavailability, and metabolism in biological matrices. LC‐tandem mass spectrometry (LC‐MS/MS) is widely employed for the quantification of Paxlovid and its metabolites in plasma, serum, and other biological samples. This study brings forth an overview of the characteristics and properties of Paxlovid along with analytical and bioanalytical methods employed for its assessment and quantification.
The physiological determinants of symptom burden in cirrhosis with ascites
Authors: Mazumder Nikhilesh R. , Jezek Filip , Ansari Sardar , Tapper Elliot B. , Lok Anna S. 
Published: October 2024

AbstractBackground & AimsParacentesis is commonly used to manage patient discomfort due to ascites. The relationship between ascites pressure, ascites volume, and patient discomfort has not been elucidated.MethodsWe prospectively enrolled adult patients with non‐malignant ascites undergoing outpatient therapeutic paracenteses from 2021 to 2024 at a tertiary care hospital. Patients completed a validated symptom questionnaire (ASI‐7, maximum score 35) before, immediately after, and 1 week after paracentesis. An open‐ended manometer was used to measure ascites pressure at the beginning and end of paracentesis. Mixed effect linear regression was performed to evaluate the relationships between patient characteristics, pressure, volume, and symptoms.ResultsOne hundred and fifty paracentesis procedures among 48 unique patients with an average Model for End Stage Liver Disease‐Sodium 3.0 of 16.7 were included. An average of 6.5 L was drained, which reduced abdominal pressure from a mean of 13.7 to 6.0 cm H2O (10.1 to 4.4 mmHg, p < 0.001) and mean symptom score from 22.6 to 6.5 (p < 0.001). Regression models identified that symptoms and abdominal pressure linearly correlated above a pressure of 6 cm H2O or ASI‐7 score of 16 (p < 0.01). Taller patients required about 670 ml additional drainage per inch above the cohort mean height (5′8″) to achieve the same symptom relief.ConclusionsPressure measured at the bedside can be used to explore changes in abdominal pressure during paracentesis. Pressure, volume, and patient level factors such as height contribute to patient symptoms but cannot fully explain discomfort associated with ascites and relief after paracentesis.
A systematic quality-integrated diagnostic method for complex product assembly using multi-task spatial–temporal transfer learning
Authors: Cheng Xun , Huang Feihong , Qiu Linqiong 
Published: October 2024

AbstractThe assembly process is generally considered one of the primary factors influencing the quality of complex products. Currently, most existing quality-integrated diagnostic methods for products tend to deteriorate over different processes and degrade over time. To address this issue, this paper introduces a systematic quality-integrated diagnostic method for complex product assembly processes. First, the influence factors and error sources in the complex assembly process are analyzed using the 5M1E and FAHP methodologies. Next, similarity-based multi-task clustering and dismantling using RGMM is applied to divide the assembly tasks. Finally, MMD-MSE is employed to develop a quality prediction model for the complex assembly process using a spatial–temporal transfer learning approach. Experiments were conducted on an array antenna assembly task, comparing the proposed method with conventional methods. The results show that the accuracy and PrUP of the proposed model are 97.6% and 95.2%, respectively, for the quality-integrated diagnostic of complex assembly processes, with a fluctuation in accuracy of less than 6%. The diagnostic results effectively meet expert evaluations and provide a stable, reliable, and practical solution for addressing quality fluctuations in complex production assembly processes.
A reduced scapulo-humeral angle contributes to the development of scapular notching in reverse total shoulder arthroplasty
Authors: Minoli Carlo , Travi Martino , Compagnoni Riccardo , Radaelli Simone , Menon Alessandra , Marcolli Daniele , Tassi Alberto , Randelli Pietro S. 
Published: October 2024

Abstract
Purpose
Scapular Notching (SN) is one of the most common postoperative complications for a patient after Reverse Total Shoulder Arthroplasty (RTSA). Despite employing various strategies to mitigate SN risk, the overall incidence remains far from zero. This article introduces a new risk factor, the scapulo-humeral angle (SHA), as a key element influencing the risk for SN.

Methods
A retrospective analysis was conducted on all patients who underwent RTSA for rotator cuff arthropathy at the study centre. The preoperative SHA was measured, and the presence of SN was investigated and graded using the Nerot classification at the latest follow-up.

Results
42 patients were included. 12 presented SN (incidence 28.5%). A statistically significant Pearson coefficient correlation between pre-operative SHA and the incidence of SN was observed (r= -0.6954; 95% C.I. -0,8250 to -0,4963; p < 0.0001). A statistically significant Pearson coefficient correlation was also found between the degree of SN and the pre-operative SHA (r= -0,7045; 95% C.I. -0,8306 to -0,5096; P value (two-tailed) < 0,0001, alpha 0.05).

Conclusions
The primary finding is a statistically significant correlation between a reduced preoperative SHA and an increased incidence of postoperative SN. The secondary finding is that a smaller preoperative SHA is associated with a more severe degree of SN A SHA cut-off of 50° distinguished patients at high risk of SN from those at low risk. All patients with an SHA below 50° developed SN (10/10), whereas only 6.25% of patients with an SHA exceeding 50° experienced SN (2/32).
Peak-CNN: improved particle image localization using single-stage CNNs
Authors: Godbersen Philipp , Schanz Daniel , Schröder Andreas 
Published: October 2024

AbstractAn important step in the application of Lagrangian particle tracking (LPT) or in general for image-based single particle identification techniques is the detection of particle image locations on the measurement images and their sub-pixel accurate position estimation. In case of volumetric measurements, this constitutes the first step in the process of recovering 3D particle positions, which is usually performed by triangulation procedures. For two-component 2D measurements, the particle localization results directly serve as input to the tracking algorithm. Depending on the quality of the image, the shape and size of the particle images and the amount of particle image overlap, it can be difficult to find all, or even only the majority, of the projected particle locations in a measurement image. Advanced strategies for 3D particle position reconstruction, such as iterative particle reconstruction (IPR), are designed to work with incomplete 2D particle detection abilities but even they can greatly benefit from a more complete detection as ambiguities and position errors are reduced. We introduce a convolutional neural network (CNN) based particle image detection scheme that significantly outperforms current conventional approaches, both on synthetic and experimental data, and enables particle image localization with a vastly higher completeness even at high image densities.
Clinical outcomes of children with COVID-19 and appendicitis: a propensity score matched analysis
Authors: Odegard Marjorie N. , Keane Olivia A. , Ourshalimian Shadassa A. , Russell Christopher J. , Lee William G. , O’Guinn Makayla L. , Houshmand Laura M. C. , Kelley-Quon Lorraine I. 
Published: October 2024

Abstract
Objective
Early in the COVID-19 pandemic, many children with appendicitis and COVID-19 were initially treated non-operatively and later underwent interval appendectomy. Currently, children with both appendicitis and COVID-19 frequently undergo upfront appendectomy. The impact of this return to upfront surgical management on patient outcomes is unknown. This study compared outcomes of pediatric patients with and without COVID-19 infection undergoing appendectomy.

Study design
A retrospective cohort study of children < 21y who underwent appendectomy from 3/19/2020 to 7/31/2022 at 50 Pediatric Health Information System children’s hospitals was conducted. Children with documented COVID-19 were identified. Exclusions included preoperative ventilator or supplemental oxygen dependence, and missing data. To evaluate COVID-19 positive versus COVID-19 negative patients, we used a propensity score matched on sociodemographics, comorbidities, laparoscopy, perforation, and hospital. Chi-square and Mann–Whitney U tests identified differences between groups in length of stay, postoperative drain placement, 30-day re-admission, and mechanical ventilation requirements.

Results
Overall, 51,861 children of median age 11y (IQR: 8–14) underwent appendectomy, of whom 1,440 (2.3%) had COVID-19. Most were male (60.3%), White (72.1%) and non-Hispanic (61.4%). Public insurance was the most common (47.5%). We created a matched cohort of 1,360 COVID-19 positive and 1,360 COVID-19 negative children. Children with COVID-19 had shorter hospitalizations (1d, IQR: 1–4 vs. 2d, IQR: 1–5, p = 0.03), less postoperative peritoneal drain placement (2.4% vs. 4.1%, p = 0.01), and fewer 30-day readmissions (9.0% vs. 11.4%, p = 0.04). However, no difference in incidence or duration of mechanical ventilation (p > 0.05) was detected.

Conclusions
Our findings suggest that upfront appendectomy for children with appendicitis and COVID-19 has similar outcomes compared to children without COVID-19.

Level of evidence
Level III.
Real-world experience in initiation of treatment with the selective cardiomyosin inhibitor mavacamten in an outpatient clinic cohort during the 12-week titration period
Authors: Becker Finn , Novotny Julia , Jansen Nadine , Clauß Sebastian , Möller-Dyrna Florian , Specht Birge , Orban Madeleine , Massberg Steffen , Kääb Stefan , Reichart Daniel 
Published: October 2024

Abstract
Introduction
Lately, mavacamten emerged as a new therapeutic option for symptomatic patients with obstructive hypertrophic cardiomyopathy (oHCM). Clinical trials revealed reduction of serum biomarkers, and left ventricular outflow tract (LVOT) obstruction, as well as an improvement in clinical symptoms and exercise capacity. Nevertheless, clinical experience and manageability of patients in a real-world setting is still lacking.

Material and methods
22 patients with symptomatic oHCM (54.5% male, age 58.5 ± 16.2 years) and elevated LVOT gradients were started on mavacamten between March 2023 and June 2024. All patients were New York Heart Association (NYHA) class II or higher. Seven patients were excluded from primary analysis due to comedication with Angiotensin-converting-enzyme-inhibitors or Angiotensin-II receptor blockers. Cardiac imaging, laboratory work-up and clinical evaluation were assessed at three visits during the 12 weeks initiation phase; Dosing of mavacamten was adjusted according to manufacturer’s recommendations.

Results
At 12 weeks, the majority of patients described a significant improvement of their quality of life. Work-up at 12 weeks revealed a significant reduction of serum biomarkers and LVOT gradients. In four patients, mavacamten needed to be temporarily paused due to clinical complaints or transient left ventricular ejection fraction deterioration below 50% with subsequent full recovery.

Conclusion
We provide first insights into the usage of mavacamten in oHCM patients during the titration period in a real-world setting. Clinical findings are in line with previous clinical trials. In accordance with current recommendations, we highlight the need for standardized follow-up of patients on mavacamten treatment.
Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline
Authors: Liu Joan , Binding Lawrence , Puntambekar Isha , Patodia Smriti , Lim Yau Mun , Mryzyglod Alicja , Xiao Fenglai , Pan Shengning , Mito Remika , de Tisi Jane , Duncan John S. , Baxendale Sallie , Koepp Matthias , Thom Maria 
Published: October 2024

AbstractWhite matter microvascular alterations in temporal lobe epilepsy (TLE) may be relevant to acquired neurodegenerative processes and cognitive impairments associated with this condition. We quantified microvascular changes, myelin, axonal, glial and extracellular-matrix labelling in the gyral core and deep temporal lobe white matter regions in surgical resections from 44 TLE patients with or without hippocampal sclerosis. We compared this pathology data with in vivo pre-operative MRI diffusion measurements in co-registered regions and neuropsychological measures of cognitive impairment and decline. In resections, increased arteriolosclerosis was observed in TLE compared to non-epilepsy controls (greater sclerotic index, p < 0.001), independent of age. Microvascular changes included increased vascular densities in some regions but uniformly reduced mean vascular size (quantified with collagen-4, p < 0.05–0.0001), and increased pericyte coverage of small vessels and capillaries particularly in deep white matter (quantified with platelet-derived growth factor receptorβ and smooth muscle actin, p < 0.01) which was more marked the longer the duration of epilepsy (p < 0.05). We noted increased glial numbers (Olig2, Iba1) but reduced myelin (MAG, PLP) in TLE compared to controls, particularly prominent in deep white matter. Gene expression analysis showed a greater reduction of myelination genes in HS than non-HS cases and with age and correlation with diffusion MRI alterations. Glial densities and vascular size were increased with increased MRI diffusivity and vascular density with white matter abnormality quantified using fixel-based analysis. Increased perivascular space was associated with reduced fractional anisotropy as well as age-accelerated cognitive decline prior to surgery (p < 0.05). In summary, likely acquired microangiopathic changes in TLE, including vascular sclerosis, increased pericyte coverage and reduced small vessel size, may indicate a functional alteration in contractility of small vessels and haemodynamics that could impact on tissue perfusion. These morphological features correlate with white matter diffusion MRI alterations and might explain cognitive decline in TLE.
Lymphomas of the submandibular gland: a nationwide cohort study
Authors: Al-Shahrestani Fahd , Al-Khafaf Ahmed Ehsan , Asheer Zain , Jelicic Jelena , Chanchiri Iman , Blocher Catharina E. , Sørensen Anne Kathrine Aalling , Pedersen Lars Møller , Gjerdrum Lise Mette Rahbek , Heegaard Steffen , Homøe Preben 
Published: October 2024

Abstract
Objective
This study explores the epidemiology, incidence, and survival outcomes associated with lymphomas of the submandibular gland (SMG) and examines the influence of autoimmune diseases on these parameters.

Methods
This retrospective nationwide cohort study analysed data from patients diagnosed with SMG lymphomas in Denmark between 2000 and 2020. Information was extracted from medical records, the National Pathology Register, and the Danish Lymphoma Database. Survival analyses were conducted using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models, focusing on lymphoma subtypes and autoimmune diseases.

Results
The cohort consisted of 101 patients with a lymphoma diagnosis and involvement of the SMG. Large B-cell lymphoma (LBCL) was diagnosed in 33 cases (32.7%), follicular lymphoma (FL) in 29 cases (28.7%), extranodal marginal zone lymphoma (EMZL) in 27 cases (26.7%), and 12 cases (11.9%) with other subtypes. EMZL had a significantly longer overall survival (OS) compared to other subtypes, with a median OS of 12.4 years (95% CI 11.2–12.4) vs. 8.4 years (95% CI 6.0-12.2). EMZL and FL showed favourable 5-year OS rates of 95% and 89%, respectively. LBCL had a 5-year OS rate of 65%. Age over 60 significantly negatively impacted OS. Traditional poor prognostic indicators did not significantly affect OS. A notable association between EMZL and autoimmune diseases was observed, particularly with Sjögren’s syndrome, indicated by an increased relative risk of 2.67 (CI 95% 0.45–16.01).

Conclusions
Lymphomas of the SMG are rare and have ambiguous clinical presentations. This study provides novel epidemiological, clinical, and prognostic information.
Spatial and temporal mush heterogeneity during eruptions recorded in clinopyroxene from the 2021 paroxysms at Mt. Etna, Italy
Authors: MacDonald Alice , Ubide Teresa , Mollo Silvio , Taddeucci Jacopo 
Published: October 2024

AbstractTextural and compositional zoning of volcanic minerals archives pre-eruptive magma processes. Crystals erupted simultaneously may be sampled from different regions of the plumbing system and hence record variable histories due to complex magma dynamics. In addition, crystals erupted throughout the course of an eruption may record temporal variations in the plumbing system. To resolve mush variability on both spatial and temporal scales, we investigate clinopyroxene erupted during a series of paroxysmal episodes between February–April 2021 at Mt. Etna, Italy. Using a combination of high-resolution geochemical techniques, we observe that Cr enrichments in clinopyroxene mantle zones, grown upon eruption-triggering mafic rejuvenation, exhibit both temporal and spatial (sample-scale) variability. Temporal variability correlates with changes in glass compositions, attesting to the ability of clinopyroxene to track magma maficity throughout an eruption. Spatial variability, indicated by the scatter of Cr concentrations, is greatest for the first event and lowest for the final paroxysm. In conjunction with core textures, degree of sector enrichment and thermobarometry, our data suggest that the onset of the paroxysms was preceded by the remobilisation of a mid-crustal clinopyroxene mush (534 ± 46 MPa) by hot, mafic magma causing variable resorption of mush-derived crystal cores. Towards the end of the eruption, waning magma supply led to less efficient mush remobolisation and mixing, resulting in homogenous crystal populations. Our results highlight that clinopyroxene Cr contents and sector enrichment can be used to track mafic rejuvenation and magma evolution throughout eruptions, while also reflecting spatial heterogeneities within the plumbing system.
Unveiling STRs instability in a colorectal cancer FFPE sample: a case report
Authors: Soldati Giulia , Saccardo Chiara , Raniero Dario , De Leo Domenico , Turrina Stefania 
Published: October 2024

Abstract
In forensic genetics, sometimes formalin-fixed paraffin-embedded (FFPE) biopsy material taken during life is the only biological sample available for individual identification or paternity testing. In most cases, this biological tissue is characterized by the presence of tumor cells characterized by instability and loss of heterozygosity of microsatellites (MSI/LOH) compared to the DNA present in cells of normal tissue.In this case report, two FFPE samples from the same male subject were available for genetic investigation: one sample with colorectal cancer tissue and the other with normal tissue (no cancerous histopathological features). The comparison of the genetic profiles obtained from DNA extracted from the two tissues showed in the tumor tissue the presence of three genomic instability phenomena affecting FGA, CSF1P0, D21S2055 loci, located on three distinct autosomal chromosomes, and one duplication phenomenon affecting the DYS438. Therefore, due to the MSI/LOH phenomena, the genetic profile acquired from the tumor tissue was distorted and thus generated a fictitious genetic profile, not corresponding to the subject’s real one (normal tissue free of tumor cells).