bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early evaluation of severity in patients with severe sepsis: a comparison with “septic shock” — subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM‐SR)
Authors: Tarui Takehiko , Yamaguchi Yoshihiro , Suzuki Koichiro , Tsuruta Ryosuke , Ikeda Hiroto , Ogura Hiroshi , Kushimoto Shigeki , Kotani Joji , Shiraishi Shin‐ichiro , Suzuki Yasushi , Takuma Kiyotsugu , Takeyama Naoshi , Fujishima Seitaro , Mayumi Toshihiko , Miki Yasuo , Yamashita Norio , Aikawa Naoki , Gando Satoshi 
Published: July 2017

AimThe purpose of this subgroup analysis of a Japanese multicenter registry, the Japanese Association for Acute Medicine Sepsis Registry Advanced (JAAM‐SR‐Advanced), was to identify early outcome indicators for severe sepsis that are useful and more objective than “septic shock.”MethodsAmong 624 patients with severe sepsis registered in JAAM‐SR‐Advanced, 554 with valid serum lactate data were retrospectively studied. Hypotension before and after fluid resuscitation and the highest lactate values over the initial 24 h were compared for their ability to predict in‐hospital mortality.ResultsOf the study group, 155 (28.0%) patients were non‐survivors and had significantly lower systolic blood pressures and higher lactate peaks. The mortality of 364 patients with initial hypotension was higher than those patients without it (32.7% versus 19.1%, P < 0.01). Patients with the worst lactate values ≥4 mmol/L had much higher mortality than other patients (P < 0.001). In an attempt to predict outcomes, we combined initial hypotension and the worst lactate values. The patient group with initial hypotension and the worst lactate values ≥4 mmol/L (183 patients, 33.0%) had a significantly higher mortality rate of 48.6% than the other groups (P < 0.01).ConclusionThe novel combined criterion of initial hypotension and the worst lactate values ≥4 mmol/L within the initial 24 h is potentially useful as a single outcome predictor for severe sepsis.
Myelopathy in Behçet's disease: The Bagel Sign
Authors: Uygunoglu Ugur , Zeydan Burcu , Ozguler Yesim , Ugurlu Serdal , Seyahi Emire , Kocer Naci , Islak Civan , Kantarci Kejal , Saip Sabahattin , Siva Aksel , Kantarci Orhun H. 
Published: July 2017

ObjectiveTo describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease (BD).MethodsWe evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow‐up duration ≥ 1 year after initial MRI evaluation. Patients not fulfilling all inclusion criteria and having MRIs with poor quality or missing sequences were excluded.ResultsIn 11 patients (9 men, 2 women), we studied 14 MRIs during distinct myelopathy episodes and nine follow‐up MRIs. Two distinct MRI patterns of spinal cord involvement were described according to T2‐weighted (T2W) axial images: (1) “Bagel Sign” pattern: a central lesion with hypointense core and hyperintense rim with or without contrast enhancement; and (2) “Motor Neuron” pattern: a symmetric involvement of the anterior horn cells. Bagel Sign was present in 13 of 14 myelopathy episodes whereas Motor Neuron pattern was observed in 1 of 14 MRIs. Of the 13 MRIs with Bagel Sign long myelopathy (n = 9), both long and short myelopathy (n = 2) and short myelopathy (n = 2) was observed. All patterns cleared with some residual lesions after steroid use and immunomodulation with associated clinical recovery in patients.InterpretationThe signal characteristics of the Bagel Sign potentially represent venous engorgement and/or acute blood products within the spinal cord. To our knowledge, Bagel Sign has not been observed in other forms of longitudinal myelopathy outside of BD, including neuromyelitis optica. Ann Neurol 2017;82:288–298
Copper‐Catalyzed Amination of Congested and Functionalized α‐Bromocarboxamides with either Amines or Ammonia at Room Temperature
Authors: Ishida Syo , Takeuchi Kentaro , Taniyama Nobuhiro , Sunada Yusuke , Nishikata Takashi 
Published: July 2017

AbstractThere are several reports on the synthesis of alkylamines, but most of the reported methods are not suitable for the synthesis of hindered amines. In this research, we found that a copper catalyst is effective for the formation of congested C−N bonds at room temperature. Control experiments revealed that a copper amide is a key intermediate. Moreover, when a chiral amine was used, a quaternary carbon stereogenic center was created with good selectivity.
A ferrocene‐containing porous organic polymer linked by tetrahedral silicon‐centered units for gas sorption
Authors: Ma Qingyu , Qi Yipeng , Li Jianquan , Wang Weiguo , Sun Xuejiao 
Published: July 2017

A novel ferrocene‐containing porous organic polymer (FPOP) has been prepared by Sonogashira‐Hagihara coupling reaction of 1,1′‐dibromoferrocene and tetrakis(4‐ethynylphenyl)silane. Compared with other polymers, the resulting polymer possesses excellent thermal stability with the decomposition temperature of 415°C and high porosity with Brunauer–Emmett–Teller (BET) surface area of 542 m2 g−1 as measured by nitrogen adsorption‐desoprtion isotherm at 77 K. For applications, it shows moderate carbon dioxide uptakes of up to 1.42 mmol g−1 (6.26 wt%) at 273 K/1.0 bar and 0.82 mmol g−1 (3.62 wt%) at 298 K/1.0 bar, and hydrogen capacity of up to 0.45 mmol g−1 (0.91 wt%) at 77 K/1.0 bar, indicating that FPOP might be utilized as a promising candidate for storing carbon dioxide and hydrogen. Although FPOP possesses lower porosity than many porous polymers, the gas capacities are higher or comparable to them, thereby revealing that the incorporation of ferrocene units into the network is an effective strategy to enhance the affinity between the framework and gas.
CuO nanoparticles supported on three‐dimensional nitrogen‐doped graphene as a promising catalyst for thermal decomposition of ammonium perchlorate
Authors: Hosseini Seyed Ghorban , Khodadadipoor Zahra , Mahyari Mojtaba 
Published: July 2017

In the present work, CuO nanoparticles grown on three‐dimensional nitrogen‐doped graphene‐based frameworks (CuO@3D‐(N)GFs) were synthesized using a two‐step method. After the synthesis of three‐dimensional nitrogen‐doped graphene, CuO nanoparticles were deposited on it, by adding cupric acetate followed by thermal treatment. Different analysis methods were used to characterize the products. The as‐prepared nanocomposite was used as a promising catalyst for thermal decomposition of ammonium perchlorate (AP) as one of the most common oxidizer in composite propellants. Differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA) techniques were used to investigate the thermal decomposition of ammonium perchlorate. According to the DSC/TGA, high temperature decomposition of AP decreased to 111 °C in the presence of 4% CuO@3D‐(N)GFs and the total heat release (ΔH) from decomposition of AP increased to 1893 J g−1 which is much more than 590 J g−1 for pure AP.
Microwave‐assisted rapid fabrication of antibacterial polyacrylonitrile microfibers/nanofibers via nitrile click chemistry and electrospinning
Authors: Wang Wenxiang , Wang Yuxue , Liu Ye , Jiang Linlin , Bai Liangjiu , Chen Hou , Cheng Zhenping 
Published: July 2017

ABSTRACTPostmodified polyacrylonitrile (PAN) microfibers/nanofibers with durable antibacterial performance was fabricated by a rapid and green method of microwave irradiation and electrospinning technologies. The fibers were endowed with antibacterial activity because of silver ions, which were embedded into PAN by nitrile click chemistry with microwave irradiation; they were then electrospun into neat and smooth microfibers/nanofibers. The obtained microfibers/nanofibers were tested against Staphylococcus aureus and exhibited powerful and long‐lasting antibacterial properties. The production of endurable antibacterial materials could effectively prevent the spread of microbes and beautify the living environment. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45490.
Cationization of cellulose/polyamide on UV protection, bio‐activity, and electro‐conductivity of graphene oxide‐treated fabric
Authors: Hasani Mahfam , Montazer Majid 
Published: July 2017

ABSTRACTIn this work, cationized cotton/nylon fabric was treated with reduced graphene oxide (rGO) to produce highly conductive fabric. The fabric was cationized with 3‐chloro‐2‐hydroxy propyl trimethyl ammonium chloride to attract more anionic GO. The fabric was then treated with GO followed by reduction with sodium dithionite. The results of energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, and X‐ray photoelectron spectroscopy indicated entire coverage of the fabric surface with rGO. The color of fabrics changed to gray‐black and the electrical resistance decreased to 0.6 × 103 Ω sq−1. The washing fastness was measured according to ISO 105‐CO5 for color change and also electrical resistance of the samples demonstrated well stability of rGO on the fabric surface. The antibacterial activities of the treated fabrics improved against Gram‐negative bacteria including Escherichia coli (84.8%) and Pseudomonas aeruginosa (96.4%) and also Gram‐positive bacteria consisting Staphylococcus aureus (100%) and Enterococcus faecalis (98.4%). Further, the treated fabrics indicated an excellent UV reflectance of 100%. Finally heating of the cationized rGO fabric at 220 °C displayed a lower electrical resistance of 0.5 × 103 Ω sq−1. The thermogravimetric analysis showed that heating has a slight effect on the dimensional thermal stability of the treated fabric as shrunk 2.43%. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45493.
Improving adhesion between aramid fibers and natural rubber through morphological and synthetic modification of the fibers
Authors: Kanbargi Nihal , Lesser Alan J. 
Published: July 2017

ABSTRACTIn this article, we present new methods to improve the adhesion between poly(paraphenylene terephthalamide) fibers and a natural rubber for tire reinforcement. Fiber pretreatments are applied to create new surface morphologies on the fiber that enables enhanced adhesion between the fiber and rubber matrix. The pretreated fibers are then subject to treatments with coupling agents in the presence of supercritical carbon dioxide (scCO2) in an attempt to permeate the fiber surface and chemically bind the fiber to the rubber matrix. Shear lag analysis using a Kelly Tyson approach is compared to more refined models to evaluate optimum test parameters for fiber pull‐out adhesion tests. The results show that the adhesion increases by approximately 100% when compared to conventional composites. Failure analysis of fiber surface reveals a suppression of interfacial failure. The effects of pretreatments on fiber properties are also characterized, and the optimization between fiber properties, fiber–matrix interface properties, and overall composite properties are discussed. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45520.
Influence of TFAP2B and KCTD15 genetic variability on personality dimensions in anorexia and bulimia nervosa
Authors: Gamero‐Villarroel Carmen , González Luz M. , Rodríguez‐López Raquel , Albuquerque David , Carrillo Juan A. , García‐Herráiz Angustias , Flores Isalud , Gervasini Guillermo 
Published: July 2017

AbstractIntroductionTFAP2B and KCTD15 are obesity‐related genes that interact to regulate feeding behavior. We hypothesize that variability in these loci, isolated or in combination, could also be related to the risk of eating disorders (ED) and/or associated psychological traits.MethodsWe screened 425 participants (169 ED patients, 75 obese subjects, and 181 controls) for 10 clinically relevant and tag single‐nucleotide polymorphisms (SNPs) in KCTD15 and TFAP2B by the Sequenom MassARRAY platform and direct sequencing. Psychometric evaluation was performed with EDI‐2 and SCL‐90R inventories.ResultsThe KCTD15 rs287103 T variant allele was associated with increased risk of bulimia nervosa (BN) (OR = 4.34 [1.47–29.52]; p = .003) and with scores of psychopathological scales of these patients. Haplotype *6 in KCTD15 was more frequent in controls (OR = 0.40 [0.20–0.80], p = .009 for anorexia nervosa), while haplotype *4 in TFAP2B affected all three scales of the SCL‐90R inventory in BN patients (p ≤ .01). Epistasis analyses revealed relevant interactions with body mass index of BN patients (p < .001). Genetic profiles in obese patients did not significantly differ from those found in ED patients.ConclusionsThis is the first study that evaluates the combined role of TFAP2B and KCTD15 genes in ED. Our preliminary findings suggest that the interaction of genetic variability in these loci could influence the risk for ED and/or anthropometric and psychological parameters.
Multiple myeloma presenting in association with gastric phytobezoar
Authors: Appleton Elizabeth S. , Lee Natasha A. , Ford Alexander C. 
Published: July 2017

Key Clinical MessageWe present a rare case of a patient with delayed gastric emptying, gastric phytobezoar formation, and osteosclerotic bone lesions as an atypical association with multiple myeloma. Associated gastric features in myeloma, which include diffuse infiltration, gastric plasmacytomas, or delayed gastric emptying, are rare and have a poor prognosis.
Formation of Spherical Agglomerates in Cooling Crystallization of Hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine
Authors: Lee Jae-Eun , Kim Jae-Kyeong , Kim Hyoun-Soo , Koo Kee-Kahb 
Published: July 2017

AbstractThe production of spherical agglomerates of hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine (RDX) from acetone by cooling crystallization with poly(vinylpyrrolidone) (PVP) is described. It was found that PVP suppresses the nucleation of RDX at the initial stage, but tremendous nucleation of RDX occurred abruptly after the induction period. The rapid nucleation may be associated with the primary nucleation due to the presence of PVP. It can be concluded that the addition of PVP results in the formation of RDX particles with sufficient number density for spherical agglomeration. It was found that such spherical agglomeration propagates very rapidly after nucleation within one minute and the size of spherical agglomerates is affected by the cooling rate.
The Stepwise Reaction of Rhodium and Iridium Complexes of Formula [MCl2(κ4C,N,N′,P−L)] with Silver Cations: A Case of trans‐Influence and Chiral Self‐Recognition
Authors: Carmona María , Tejedor Leyre , Rodríguez Ricardo , Passarelli Vincenzo , Lahoz Fernando J. , García‐Orduña Pilar , Carmona Daniel 
Published: July 2017

AbstractAcetonitrile suspensions of the dichlorido complexes [MCl2(κ4C,N,N′,P−L)] [M=Rh (1), Ir (2)] react with AgSbF6 in a 1:2 molar ratio affording the bis‐acetonitrile complexes [M(κ4C,N,N′,P−L)(NCMe)2][SbF6]2 (3 and 4). The reaction takes place in a sequential manner and the intermediates can be isolated varying the M:Ag molar ratio. In a 2:1 molar ratio, it affords the dimetallic monochlorido‐bridged compounds [{MCl(κ4C,N,N′,P−L)}2(μ‐Cl)][SbF6] (5 and 6). In a 1:1 molar ratio, the monosubstituted solvato‐complexes [MCl(κ4C,N,N′,P−L)(Solv)][SbF6] (Solv=H2O, MeCN, 7–10) were obtained. Finally, in a 2:3 molar ratio, it gives complexes 11 and 12 of formula [{M(κ4C,N,N′,P−L)(NCMe)(μ‐Cl)}2Ag][SbF6]3 in which a silver cation joints two cationic monosubstituted acetonitrile‐complexes [MCl(κ4C,N,N′,P−L)(NCMe)]+ through the remaining chlorido ligands and two Ag⋅⋅⋅C interactions with one of the phenyl rings of each PPh2 group. In all the complexes, the aminic nitrogen and the central metal atom are stereogenic centers. In the trimetallic complexes 11 and 12, the silver atom is also a stereogenic center. The formation of the cation of the dimetallic complexes 5 and 6, as well as that of the trimetallic complexes 11 and 12, takes place with chiral molecular self‐recognition. Experimental data and DFT calculations provide plausible explanations for the observed molecular recognition. The new complexes have been characterized by analytical, spectroscopic means and by X‐ray diffraction methods.
Fast further purification of diastereomeric salts of a nonracemic acid by gas antisolvent fractionation
Authors: Kőrösi Márton , Madarász János , Sohajda Tamás , Székely Edit 
Published: July 2017

AbstractA novel, green possibility of the further purification of the diastereomeric salt of 4‐chloromandelic acid and 1‐phenylethane‐1‐amine was developed. Gas antisolvent method using supercritical carbon dioxide was applied for the first time to precipitate the diastereomeric salts with increased purity followed by the supercritical fluid extraction of the dissolved diastereomers. The RR‐salt can be purified to >99%, while fractionation‐based purification of the SR‐salt is limited to ~80%. The limiting initial diastereomeric excess correlates strongly with the atmospheric melting eutectic composition of the same salts, which suggests that despite the fast precipitation, the diastereomeric excess of the solid product is not kinetically determined. The efficiency of the diastereomeric enrichment is in the same range as that of the atmospheric reference experiments; however, technological advantages provided by the antisolvent precipitation method such as fast processing and dry product obtained suggest that this novel procedure is a promising alternative to the atmospheric methods.
Modification des propriétés du brai de goudron de houille utilisé dans la fabrication des anodes
Authors: Bureau Julie , Kocaefe Duygu , Kocaefe Yasar , Bhattacharyay Dipankar , Morais Brigitte 
Published: July 2017

RésuméLa fabrication de l'aluminium par le procédé d'électrolyse nécessite l'utilisation des anodes. Or, la qualité des anodes a un impact direct sur le coût du métal, la consommation d'énergie et les émissions environnementales. Une liaison satisfaisante entre le coke et le brai affecte fortement les propriétés finales de l'anode. Une des avenues les plus prometteuses pour améliorer cette liaison est la modification des propriétés du brai. L'objectif de ce travail est d'améliorer la mouillabilité du coke par le brai en modifiant les propriétés du brai par l'ajout de produits chimiques. Des tensioactifs ou agents de modification de surface sont sélectionnés afin d'enrichir les groupements fonctionnels requis pour augmenter la mouillabilité. De plus, les additifs chimiques sont choisis en fonction de l'impact environnemental de même que l'impact économique de cet ajout d'additif pour l'industrie tout en prévenant la contamination des anodes. La méthodologie prévoit d'analyser la composition chimique des brais modifiés par la spectroscopie infrarouge à transformée de Fourier (FTIR) afin d'évaluer l'enrichissement des groupements fonctionnels requis. Puis, l'interaction du brai modifié en présence du coke est vérifiée par la méthode goutte‐sessile afin d'en évaluer la mouillabilité du coke par le brai. Une amélioration de la mouillabilité signifie une possible amélioration de l'interaction entre les deux matériaux pouvant améliorer les propriétés anodiques. Dans cette étude, deux des additifs sélectionnés ont permis de démontrer une modification significative des propriétés du brai favorisant l'amélioration de la compatibilité du brai avec le coke.
A new type of neurons for machine learning
Authors: Fan Fenglei , Cong Wenxiang , Wang Ge 
Published: July 2017

AbstractIn machine learning, an artificial neural network is the mainstream approach. Such a network consists of many neurons. These neurons are of the same type characterized by the 2 features: (1) an inner product of an input vector and a matching weighting vector of trainable parameters and (2) a nonlinear excitation function. Here, we investigate the possibility of replacing the inner product with a quadratic function of the input vector, thereby upgrading the first‐order neuron to the second‐order neuron, empowering individual neurons and facilitating the optimization of neural networks. Also, numerical examples are provided to illustrate the feasibility and merits of the second‐order neurons. Finally, further topics are discussed.
Four years comparative follow‐up evaluation of community‐based, step‐down, and residential specialist psychodynamic programmes for personality disorders
Authors: Chiesa Marco , Cirasola Antonella , Fonagy Peter 
Published: July 2017

Although the fulcrum of service provision for personality disorder (PD) has shifted from hospital‐based to psychodynamically‐ and cognitively‐oriented outpatient programmes, very few studies have attempted to compare specialist moderate intensity outpatient programmes with specialist high‐intensity residential models, or to explore whether a period of inpatient treatment may be necessary to improve outcome and prognosis. In this article, we prospectively compare changes over a 4‐year period in 3 groups of patients with personality disorders (N = 162) treated in a specialist community‐based (CBP, N = 30), a step‐down (RT‐CBP, N = 87), and a specialist residential programme (RT, N = 45) in psychiatric distress, deliberate self‐injury, and suicide attempt using multilevel modelling and multivariate logistic regression analyses. The results showed that percentages of early‐dropout were significantly different (p = .0001) for the 3 programmes (CBP = 13.4%, RT‐CBP = 10.2%, and RT = 41.4%). A significant interaction between treatment model and time was found for psychiatric distress (p = .001), with CBP and RT‐CBP achieving more marked changes (g = 1.20 and g = 0.68, respectively) compared to RT (g = 0.30) at 48‐month follow‐up. CBP and RT‐CBP were found to significantly reduce impulsive behaviour (deliberate self‐injury and suicide attempt) compared to RT. Severity of presentation was not found to be a significant predictor of outcome. Long‐term RT showed no advantage over long‐term CBP, either as stand‐alone or as step‐down treatment. Replication may be needed to confirm generalizability of results, and a number of limitations in the study design may moderate the inferences that can be drawn from the results.
An ECC‐based authenticated group key exchange protocol in IBE framework
Authors: Gupta Daya Sagar , Biswas G. P. 
Published: July 2017

SummaryWith the rapid demand for various increasing applications, the internet users require a common secret key to communicate among a group. The traditional key exchange protocols involve a trusted key generation center for generation and distribution of the group key among the various group members. Therefore, the establishment of a trusted key generation center server and the generation (and distribution) of common session key require an extra overhead. To avoid this difficulty, a number of group key exchange protocols have been proposed in the literature. However, these protocols are vulnerable to many attacks and have a high computational and communication cost. In this paper, we present an elliptic curve cryptography–based authenticated group key exchange (ECC‐AGKE) protocol, which provides better security and has lower computational cost compared to related proposed schemes. Further, a complexity reduction method is deployed to reduce the overall complexity of the proposed elliptic curve cryptography–based authenticated group key exchange protocol. The security of proposed work is ensured by the properties of elliptic curves. A security adversarial model is given and an extensive formal security analysis against our claim is done in the random oracle model. We also made a comparison of our proposed protocol with similar works and found that ours have better complexity, security and efficiency over others.