bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intratracheal Dilation-injection Technique in the Treatment of Granulomatosis with Polyangiitis Patients with Subglottic Stenosis
Authors: Fijolek Justyna , Wiatr Elzbieta , Gawryluk Dariusz , Martusewicz-Boros Magdalena Maria , Orlowski Tadeusz Maria , Dziedzic Dariusz , Polubiec-Kownacka Malgorzata , Oniszh Karina , Langfort Renata , Roszkowski-Sliz Kazimierz 
Published: September 2016

Objective.An analysis of subglottic stenosis (SGS) occurrence frequency in patients with granulomatosis with polyangiitis (GPA) based on the time of appearance of clinical symptoms, and an assessment of treatment effectiveness, in particular with the intratracheal dilation-injection technique (IDIT).Methods.Review and treatment with IDIT of 34 patients with SGS associated with GPA.Results.SGS developed in 34 of 250 patients with GPA (13.6%) and was not reflective of disease activity in the organs in 15 of 34 patients (44%): 11 cases after and 4 cases during immunosuppressive therapy (IST) when patients did not have organ symptoms. All patients underwent IDIT and in total, the treatment resulted in immediate improvement. In addition, in 21 cases, IST was applied because of other organ involvement or of the lack of longterm efficacy of IDIT. The median time of response was 37 months and the median interval between sessions was 5 months. None of the patients required tracheostomy after beginning IDIT in our hospital.Conclusion.SGS often occurs independently of other features of active GPA. IDIT is a safe and effective technique in the treatment of GPA-related SGS. It should be performed in all patients with GPA who develop significant SGS and in those with multiorgan disease concomitantly with IST. In patients with isolated SGS, IDIT also makes IST and tracheostomy unnecessary.
Beta2-glycoprotein I Expression in Lupus Nephritis Patients with Antiphospholipid-associated Nephropathy
Authors: Gao Ruitong , Yu Wenqing , Wen Yubing , Li Hang 
Published: September 2016

Objective.Antiphospholipid-associated nephropathy (aPLN) is a severe condition in patients with lupus nephritis (LN). aPLN should be distinguished from other reasons for renal ischemia. The most important cofactor of antiphospholipid antibodies (aPL), β2-glycoprotein I (β2GPI), was shownin vitroto bind endothelial cells and to induce a procoagulant phenotype. The objectives of this study were to investigate whether β2GPI expression was involved in patients with LN with aPLN and to determine its specificity.Methods.We retrospectively investigated β2GPI expression in 231 renal biopsy specimens of patients with LN. Data from biopsy reports and clinical information were collected. Immunohistochemical staining for β2GPI expression was performed.Results.Histological aPLN was detected in 88 patients with LN (38.1%). The LN with aPLN consisted of 43 patients (18.6%). Expression of β2GPI was detected in endothelial cells in 14 (32.6%) in renal arteries or arterioles, 11 (25.6%) in glomerular or peritubular capillaries, and a total of 15 (34.9%) of the 43 patients with LN with aPLN. It was mainly expressed in the endothelial cells in patients with LN with aPLN (p < 0.05). The specificity of β2GPI expression in patients with LN with aPLN was 97.5%.Conclusion.Expression of β2GPI may be involved in the formation of aPLN in patients with LN. This expression in endothelial cells in kidney tissue may be considered a useful marker for aPLN.
Correlation of clivoaxial angle to skeletal malocclusions: A prescreening for future risk of neurodegenerative disorders
Authors: Bhusri Navdeep , Lim Dennis C. 
Published: September 2016

Objectives
To find out if there exists any correlation between clivoaxial angle (CXA) and skeletal malocclusions.

Materials
and Methods: Lateral cephalograms of 33 filipino patients equally divided in three types of skeletal malocclusions were traced, and cephalometric parameters CXA, BaSN, ANB, SNMPA, FMA, MMPA, and Y-axis were traced. Data underwent bivariate correlation and curve estimation analysis in SPSS 17.0 statistical software at confidence interval of 95% and 0.05 significance level.

Results
A highly significant (P = 0.003) strong negative correlation was revealed in Class III patients between CXA and BaSN.

Conclusion
Class III patients seem to have higher chances of craniocervical junction anomalies and thus might be at risk of developing neurodegenerative disorders in future.
Maxillary bone defects and their relationship to transverse maxillary discrepancies
Authors: Peña-Montero Claludia A. , Rivas-Gutierrez Rafael , Sierra-Rosales Enrique , Diaz-Peña Rogelio 
Published: September 2016

Objectives
The relationship between the presence of bone defects (fenestrations and dehiscences) observed in lateral slices in computerized axial tomography (CAT) images and maxillomandibular transverse discrepancies was determined.

Methods
The sample was composed of 160 CAT scan files, corresponding to 9–25-year-old patients, which had been taken prior to orthodontic treatment at a radiology center in Guadalajara, México, from 2009 to 2012. They were grouped by age, and we identified bone defects in maxillary teeth (first and second premolars and first molars). The maxillary (JL-JR) and mandibular (GA-AG) widths were measured, and the maxillomandibular discrepancy ([GA-AG]-[JL-JR]) was calculated. Chi-square and t-tests were performed.

Results
The values of maxillomandibular discrepancies increased with the age of the patient. There was no association between the magnitude of the maxillomandibular discrepancy and the presence of bone defects. The gender of the individual was not a decisive factor in whether bone defects were present.

Conclusion
Bone defects occur in the vast majority of patients pretreatment regardless of the magnitude of the maxillomandibular discrepancy.
Análisis de la relación entre disciplinas a través del uso de tesis doctorales. El caso de Televisión, Radio, Cine y Fotografía en España
Authors: Repiso Rafael , Torres-Salinas Daniel , Delgado López-Cózar Emilio 
Published: September 2016

El presente trabajo propone un nuevo método de análisis de la interdisciplinariedad a partir de la medición de la participación académica en las tesis doctorales en diferentes disciplinas. Metodología: Para construir las relaciones interdisciplinares se utilizan las tesis doctorales y las relaciones que se producen a partir de las direcciones de tesis y coparticipación en tribunales. Como muestra se utilizan las tesis doctorales defendidas en España en Comunicación Audiovisual (Televisión, Radio, Cine y Fotografía) en el periodo 1976-2007. El Escalamiento Multidimensional nos permite generar una representación bidimensional de las especialidades estudiadas, calcular distancias y cuantificar el grado de error de la representación. Resultados y conclusiones: Los resultados demuestran cómo se producen dos grupos diferenciados, por una parte Televisión y Radio, en segundo lugar, Cine y Fotografía. Televisión es la especialidad más representativa del conjunto. Apenas existen variaciones utilizando los diferentes tipos de participaciones.
Cadaveric dissection by students-monitors in human anatomy discipline: experience report
Authors: Moraes G. , Falcão J. , Sandes A. , Rodrigues B. , Nascimento I. , Schwingel P. , Silva Júnior E. 
Published: September 2016

Abstract
Introduction: Monitoring allows students the basic cycle of higher-level courses, principally, a deeper understanding of all content been living in class, in this case, the Human Anatomy classes. Through it the student develops various daily activities at the Human Anatomy Laboratory to that add up to the didactic and pedagogical activities required in this process, like the cadaveric dissection. Dissect derives from the Latin meaning to separate, cut, etymologically being equivalent to anatomy. The present study aimed to report the student-monitor experience the discipline of Human Anatomy in cadaveric dissection. Methods: The study is an experience report of a qualitative approach, with an exploratory descriptive analysis, whose objective was to describe, in the words of Physiotherapy course monitors, the importance in the dissection technique. For this, has been made the reading for each reporting for the identification of the central issues described by each monitor. Results: The reports were obtained in February 2014 soon after the end of the I Course of cadaveric dissection of Upper and Lower Limbs, sponsored by the Human Anatomy Laboratory of the University of Pernambuco, Petrolina, as a process of training to those student-monitors who had been selected for the period between 2014.1 and 2014.2 monitoring. Conclusion: It could be perceived that the cadaveric dissection was seen as a way to strengthen the humanization of future health professionals, which resulted in its ethical and social practice, and it has allowed an improvement in teacher-monitor-student relationship.
Regeneration of experimental long bone defect after implantation in its cavity of osteoplastic material “Calc-i-oss®”
Authors: Korenkov O. 
Published: September 2016

Abstract
Introduction: There is a significant divergence of data on the rate of resorption and replacement by the bone tissue of osteoplastic materials based on β-tricalcium phosphate in cancellous bone. At the same time in literature missing morphometric and electron microscopic features of bone tissue of the regenerate of compact substance of bone in these conditions. This study was aimed at the assessment of the healing of compact bone tissue defect after implantation of osteoplastic material “Calc-i-oss®” with the definition of the dynamics of resorption and morphological characteristics of bone tissue of the regenerate. Material and Methods: In the middle third of the diaphysis of the femur of rats there was reproduced the perforated defect to the bone-brain channel that was filled with osteoplastic material “Calc-i-oss®”. After surgery the fragments of injured bones were studied at the 60th and 120th day by methods of light microscopy with morphometry and scanning electron microscopy. Results: The conducted research revealed no inflammatory reaction at the site of the defect, signs of necrobiosis and necrosis of osteocytes in adjacent to the site of implantation maternal bone. The site of defect was filled with lamellar bone tissue high in osteoblasts, osteocytes and with integrated into its structure remains of “Calc-i-oss®”. On the surface and inside the implant there were found osteogenic cells and bone foci. It was established that the osteoplastic material throughout the observation period is subjected to development and replacement by bone tissue of the regenerate, the ratio of which on the 60th day of the experiment was 25.72 ± 2.06% to 74.28 ± 2.06%, and on the 120th day - 18.31 ± 1.54% to 81.69 ± 1.54%. Conclusion: Osteoplastic material “Calc-i-oss®” exhibits biocompatibility, osteoconductive properties, ability to resorption and is replaced by bone tissue, with which it integrates well.
Effects of diabetes mellitus type I on skeletal muscle: an integrative review
Authors: Santos A. , Silva E. , Albuquerque Y. , Oliveira B. , Caiaffo V. 
Published: September 2016

Abstract
Introduction: The Diabetes Mellitus (DM) is considered a serious public health problem in Brazil and in the world, increased by the modern life style, characterized by reduced physical activity, increased obesity and aging of the population. The diabetic myopathy is characterized as a complication in the striated skeletal muscles caused by diabetes, characterized by decreased muscle mass, weakness and reduced physical capacity. Thus the present study aimed to review in the literature the main changes suffered by muscle cells associated with Diabetes Mellitus type I. Material and Methods: The present review regards to the major studies in digital databases about the effects of DM type I on the morphology of the skeletal muscles. The search for references was performed in the following databases: Medical Literature and Retrieval System Online (MEDLINE/ PUBMED), Google Scholar and Scientific Electronic Library Online (SCIELO). Articles should have the following criteria to enter in the research: articles published in the last ten years, in English, Portuguese or Spanish and available online. Results: The database that had the highest number of publications was MEDLINE (98), followed by SCIELO (56) and Google Scholar (43). Only, 4 articles were selected. The articles were described according to the year of publication, title of work, journal and objectives. Conclusion: This review shows a clear association between diabetes mellitus type I and changes in skeletal muscle. The risks of atrophy in the muscles, especially the members, were significantly higher in patients with this syndrome than in normal patients. Which makes the issue of fundamental importance to the area of health.
Morphometric analysis of the masseter muscle post unilateral lower molar exodonty: experimental study
Authors: Benigno M. , Amstalden E. , Liberti E. , Leal N. , Rodrigues K. , Mota V. 
Published: September 2016

Abstract
Introduction: To check the morphological changes of the masseter muscle after surgical extraction of inferior molar teeth. Methods: 24 Wistar rats had samples of their masseter muscles analysed in the Optical Microscope (OM). The rats were randomly divided into three groups as follows: GI-15, GII-30, GII-60 days after surgical extraction of inferior molar teeth. Each group had 5 experimental and 3 normal control rats for OM observation. The OM allowed the morphometric study of the masseter muscle. The morphometric study was based on the measurement of the fiber's area by AXION-VISION software. ANOVA test was applied for data analysis. Results: No alteration was detected in all morphometric analysis of the masseter muscle. Conclusion: The masseter muscle adapts to the occlusal modiication caused by the extraction of the molar teeth during the analysed periods.
Could sugar intake initiate or aggravate non-alcoholic fatty liver during aging? An integrative review
Authors: Teodoro A. , Nucci R. , Gama E. , Rodrigues G. , Machado-Lima A. 
Published: September 2016

Abstract
Introduction: Non-alcoholic fatty liver disease (NAFLD) is part of the metabolic syndrome (MS) which is a clustering of risk factors that increase the incidence of cardiovascular events and diabetes mellitus (DM). The population aging process brings with it higher prevalence of MS. The prevalence of NAFLD has increased considerably, simultaneously with the expansion of MS, ranging from 15% to 25% in the general population. In Brazil, overweight plus obesity corresponds to 40% of the adult population and the prevalence found in the elderly age group reaches 81%. Thus, the carbohydrate intake has been identified as a key factor for the development of NAFLD. Objective: The purpose of this integrative review is to assess whether the sugar consumption by adults and elders may influence in the development and progression of NAFLD in individuals with or without metabolic syndrome. Materials and methods: The integrative review search was performed on PubMed database during September 2015. The selection criteria was adults and elderly people; sugar intake, such as, glucose or fructose; liver fat or NAFLD. Our major outcome was the hepatic profile because it is related to the sugar intake. We excluded review papers and studies with animals, as well as papers that were not related to our selection criteria. Results: The studies analyzed the sugar intake on hepatic de novo lipogenesis or NAFLD. Conclusion: We conclude in the most of the articles sugar intake and NAFLD have a positive correlation. However further studies are needed to elucidate the mechanism that sugars intake, mainly fructose, leads to NAFLD, or aggravating it.
Negative sensitive items and the discourse-configurational nature of Japanese
Authors: Miyagawa Shigeru , Nishioka Nobuaki , Zeijlstra Hedde 
Published: September 2016

We take up three Negative Sensitive Items (NSIs) in Japanese, Wh-MO plain negative indefinites, exceptive XP-sika, and certain minimizing indefinites, such as rokuna N (‘any decent N’). Although these three NSIs behave differently, we demonstrate that the two traditional NSI categories of Negative Concord Items (NCIs) and Negative Polarity Items (NPIs) are sufficient for characterizing these items. We argue that Wh-MO and XP-sika are NCIs, thus they contain a neg feature ([uneg]) which enters into (upward) agreement with its corresponding an uninterpretable feature ([ineg]). The third NSI, rokuna N, is an NPI. Two issues arise with XP-sika. First, it has an inherent focus feature, which distinguishes it from the other two. Second, this focus feature is syntactically active – meaning that movement is forced – only for the argument XP-sika. We argue that these properties of XP-sika associated with focus are independent of NP-sika as an NSI, and should be dealt with as an overall property of Japanese being a discourse configurational language. We introduce a case-theoretic solution to how focus becomes syntactically active solely with argument XP-sika.
Análise das Receitas do ITBI nos Principais Municípios do Rio Grande do Sul
Authors: Santos Rogelio Gerônimo dos , Nascimento Sidnei Pereira do , Fiuza-Moura Flavio Kaue 
Published: September 2016

As arrecadações das receitas tributárias fazem-se necessária para fazer frente às despesas com serviços característicos de Estados que são demandados pela sociedade. Desta forma, o objetivo deste estudo é aferir o comportamento das receitas per capita do Imposto sobre Transferências de Bens Imóveis (ITBI) entre o Município de Porto Alegre e as cidades de Caxias do Sul, Pelotas, Canoas, Santa Maria, Gravataí, Viamão, Novo Hamburgo e São Leopoldo, no período de 1998 a 2011, sob os impactos da Lei de Responsabilidade Fiscal (LRF). Para isso, utiliza-se o modelo econométrico de Ajuste de Poligonais para medir se houve quebra estrutural, em 2004 dos nove municípios avaliados e identificar o comportamento das receitas do ITBI no segundo período a partir do Município de Porto Alegre. Os resultados econométricos demostraram que os demais municípios avaliados alcançaram taxas de variações positivas na participação per capita do ITBI, no período de 2005-2011, comparados a Porto Alegre.
Elasticidades de transmissão espacial de preço do milho no Brasil: Um estudo para o Mato Grosso
Authors: Costa Junior Geraldo , Popova Nataliya Dimitrova , Canaan Thomé Tanus Tarik , Martines Filho João Gomes 
Published: September 2016

No presente estudo buscou-se analisar o milho, que dada a sua liderança no mercado de grãos, em termos de produção mundial e sua versatilidade de uso, tem ampliado sua importância em termos de segurança alimentar e como fonte de energia renovável. No Brasil, destaca-se o estado do Mato Grosso, que além de sua representatividade produtiva, tem ampliado sua integração com o mercado externo desse cereal. Nesse contexto, o presente estudo objetiva analisar o processo de transmissão de preços entre as praças produtoras de milho no estado do Mato Grosso e o mercado externo, no período de janeiro de 2009 à abril de 2015. Para tal, utilizou-se como arcabouço teórico, a lei do preço único e como instrumental metodológico, o modelo de causalidade de Granger e o modelo vetorial de correção de erros. Como resultado, no teste de Causalidade, no sentido de Granger, verificou-se uma relação de causalidade unidirecional, de Paranaguá em relação as praças de comercialização de Mato Grosso. Quanto aos testes de cointegração, apenas as regiões de Canarana, Lucas do Rio Verde e Sapezal apresentam uma relação de longo prazo com Paranaguá, entretanto no comparativo somente entre as praças do Mato Grosso, existe cointegração entre todas elas, tipificando um mercado integrado.
Determination of Lutein and Zeaxanthin Esters and Their Geometric Isomers in Carotenoid Ester Concentrates Used as Ingredients in Nutritional Supplements: Validation of a Combined Spectrophotometric-HPLC Method
Authors: Lombeida Wagner O , Rubio Fernando , Levy Luis W 
Published: September 2016

Abstract
A combined spectrophotometric-LC method is described for the determination of total lutein and zeaxanthin ester content in carotenoid ester concentrates, including their main geometrical isomers. The concept of composite-specific absorbance is introduced for this purpose. The method is applicable to carotenoid ester concentrates used as ingredients in oil suspensions and dosage forms. The sample is dissolved in a hexane–2-propanol mixture (95 + 5, v/v) for spectrophotometric measurement at a maximum absorption of ~445 nm. Subsequently, in parallel, a sample is saponified and chromatographed on a normal-phase HPLC column to determine the relative percentage profile of the main geometrical isomers of both carotenoid esters. This, in turn, is used to calculate the composite-specific absorbance of the sample for the final calculation of results. The method, which solely uses reference standards to validate chromatographic conditions, avoids the common error of applying the specific absorbance of only the trans isomer for the calculation of total carotenoid content when cis isomers are present.
Vitamin C in Infant Formula and Adult/Pediatric Nutritional Formula by Liquid Chromatography with UV Detection: Collaborative Study, Final Action 2012.22
Authors: Giménez Esther Campos , Martin Frédéric ,   Collaborators:, Schimpf K , Butler Thompson L , Aoude-Werner D , Grandois J Dalmas-Le , Wong J , Chia J , Malaviole I , Mapar M , Nguyen T , Hoard M , Joseph G , Ma L , Wu B , Rogers T , Austad J , Jensen B M , Pedersen I , Jensen S Meng , Zhang Y , Jobgen W , Weihong C , Xiuying L , Chanyuan H , Woollard D , Kneeteman E , Hernández O Hernández , Beltrán E , Weerasekera G , Frueh J , González P , Román E , Carreño M , Jaudzems G , Nijman R , Noorloos T , Yap L K , Chooi S H , Lautenschlager G J , Christiansen S , Piot D , Barba Le Brun M 
Published: September 2016

Abstract
To determine the repeatability and reproducibility values of the AOAC INTERNATIONAL First Action Method 2012.22, Vitamin C in Infant Formula and Adult/Pediatric Nutritional Formula by Liquid Chromatography with UV Detection, a collaborative study was organized The study was dividedinto two parts: method setup and qualification of participants (part 1) and collaborative study participation (part 2). During part 1, each laboratory was asked to analyze two practice samples using the aforementioned method Laboratories that provided results within a range of expected levels were qualified for part 2, where they analyzed 10 samples in blind duplicates Two of the samples were suspected of spoilage during the test and new cans of the same type of product were analyzed by a subset of laboratories in part 3. The results were compared with Standard Method Performance Requirement (SMPR®) 2012.012 established for vitamin C The precision results were within the requirements stated in the SMPR: 1.4–7.3% and 3.2–11.4% respectively, for repeatability and reproducibility Finally, Horwitz ratio values were all &lt;2 (0.5–1.7). The Expert Review Panel for Stakeholder Panel for Infant Formula and Adult Nutritionals Nutrient Methods determined that the data presented met the SMPR and therefore recommended the method be granted Final Action status.