bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel insights into the early histopathogenesis of immunodeficiency‐associated Burkitt lymphoma: a case report of Burkitt microlymphoma arising within HIV lymphadenitis
Authors: Park David , Ozkaya Neval , Hariharan Aparna 
Published: March 2016

AimsTo report a case detailing the early histopathogenesis of Burkitt lymphoma (BL), Epstein‐Barr virus (EBV) positive, in the clinical setting of HIV infection.Methods and resultsWe describe a 57 year‐old woman with newly diagnosed HIV infection who presented with unilateral localized axillary lymphadenopathy. Histopathological, immunohistochemical, and flow cytometric analyses were performed and showed EBV‐positive nests of Burkitt cells, including rare nests also positive for cytomegalovirus, exclusively located within hyperplastic monocytoid B‐cell areas of HIV lymphadenitis. Due to positron emission tomography/computed tomography findings of persistent localized lymphadenopathy with markedly increased fludeoxyglucose avidity a core needle biopsy was performed. Histopathological, immunohistochemical, fluorescence in situ hybridization, and flow cytometric analyses confirmed BL.ConclusionsEarly histopathogenesis of HIV‐associated BL occurred as nests of EBV‐positive Burkitt cells within prominent monocytoid B‐cell areas in our case. The results equip the pathologist to identify a very subtle Burkitt microlymphoma which would allow for prompt and appropriate chemotherapeutic intervention and may promote research into the possible relationship between monocytoid B cells and BL.
Species‐specific foraging strategies and segregation mechanisms of sympatric Antarctic fulmarine petrels throughout the annual cycle
Authors: Delord Karine , Pinet Patrick , Pinaud David , Barbraud Christophe , De Grissac Sophie , Lewden Agnes , Cherel Yves , Weimerskirch Henri 
Published: March 2016

Determining the year‐round distribution and behaviour of birds is necessary for a better understanding of their ecology and foraging strategies. Petrels form an important component of the high‐latitude seabird assemblages in terms of species and individuals. The distribution and foraging ecology of three sympatric fulmarine petrels (Southern Fulmar Fulmarus glacialoides, Cape Petrel Daption capense and Snow Petrel Pagodroma nivea) were studied at Adélie Land, East Antarctica, by combining information from miniaturized saltwater immersion geolocators and stable isotopes from feathers. During the breeding season at a large spatial scale (c. 200 km), the three species overlapped in their foraging areas located in the vicinity of the colonies but were segregated by their diet and trophic level, as indicated by the different chick δ15N values that increased in the order Cape Petrel < Southern Fulmar < Snow Petrel. During the non‐breeding season, the three fulmarines showed species‐specific migration strategies along a wide latitudinal gradient. Snow Petrels largely remained in ice‐associated Antarctic waters, Southern Fulmars targeted primarily the sub‐Antarctic zone and Cape Petrels migrated further north. Overall, birds spent less time in flight during the non‐breeding period than during the breeding season, with the highest percentage of time spent sitting on the water occurring during the breeding season and at the beginning of the non‐breeding period before migration. This activity pattern, together with the δ13C values of most feathers, strongly suggests that moult of the three fulmarine petrels occurred at that time in the very productive high Antarctic waters, where birds fed on a combination of crustaceans and fish. The study highlights different segregating mechanisms that allow the coexistence of closely related species, specifically, prey partitioning during the breeding season and spatial segregation at sea during the non‐breeding season.
Angiogenic mechanisms of human dental pulp and their relationship with substance P expression in response to occlusal trauma
Authors: Caviedes‐Bucheli J. , Gomez‐Sosa J. F. , Azuero‐Holguin M. M. , Ormeño‐Gomez M. , Pinto‐Pascual V. , Munoz H. R. 
Published: March 2016

AbstractAngiogenesis is the formation of new blood vessels based on a pre‐existing vasculature. It comprises two processes, sprouting of endothelial cells and the division of vessels due to abnormal growth of the microvasculature. It has been demonstrated that substance P (SP) can induce angiogenesis either by modulating endothelial cell growth (direct mechanism) or by attracting cells with angiogenic potential to the injury site (indirect mechanism). Therefore, the purpose of this article is to review the angiogenic mechanisms that regulate mineralized tissue formation in human dental pulp tissue and their relationship with SP expression as a defence response to stimuli such as the masticatory function and occlusal trauma. Articles included in this review were searched in PubMed, Scopus and ISI Web of Science databases, combining the following keywords: human dentine pulp, angiogenesis, angiogenic growth factors, neuropeptides, substance P, neurogenic inflammation, dentine matrix, dentinogenesis, occlusal trauma and dental occlusion. It is concluded that human dental pulp tissue responds to occlusal trauma and masticatory function with a neurogenic inflammatory phenomenon in which SP plays an important role in the direct and indirect mechanisms of angiogenesis by the action evoked via NK1 receptors at different cells, such as fibroblasts, endothelial and inflammatory cells, leading to new blood vessel formation which are needed to stimulate mineralized tissue formation as a defence mechanism.
Social Effects of Movement Synchrony: Increased Infant Helpfulness only Transfers to Affiliates of Synchronously Moving Partners
Authors: Cirelli Laura K. , Wan Stephanie J. , Trainor Laurel J. 
Published: March 2016

Interpersonal synchrony increases cooperation among adults, children, and infants. We tested whether increased infant helpfulness transfers to individuals uninvolved in the movement, but shown to be affiliates of a synchronously moving partner. Initially, 14‐month‐old infants (N = 48) watched a live skit by Experimenters 1 and 2 that either demonstrated affiliation or individuality. Infants in both groups were then randomly assigned to be bounced to music either synchronously or asynchronously with Experimenter 1. Infant instrumental helpfulness toward Experimenter 2 was then measured. If the two experimenters were affiliates, infants from the synchronous movement condition were significantly more helpful toward Experimenter 2 than infants from the asynchronous movement condition. However, if the two experimenters were not affiliated, synchrony effects on prosociality did not transfer to Experimenter 2. These results show the importance of musical synchrony for social interaction and suggest that infants may use an understanding of third‐party social relationships when directing their own social behaviors.
Impact of alcohol consumption on clinical aspects of gambling disorder
Authors: del Pino‐Gutiérrez Amparo , Fernández‐Aranda Fernando , Granero Roser , Tárrega Salomé , Valdepérez Ana , Agüera Zaida , Håkansson Anders , Sauvaget Anne , Aymamí Neus , Gómez‐Peña Mónica , Moragas Laura , Baño Marta , Honrubia María , Menchón José M. , Jiménez‐Murcia Susana 
Published: March 2016

AbstractSimilarities between gambling disorder and substance use disorders have been extensively described. To date, however, few studies using large clinical samples have been carried out that reliably assess the relationship between different levels of alcohol consumption and gambling disorders. The present study aimed to assess the impact of baseline alcohol consumption levels on the clinical profile in a large sample of treatment‐seeking individuals. Nine hundred and fifty‐one consecutive outpatients diagnosed with gambling disorder according to DSM‐IV criteria were compared after being included in three alcohol consumption groups (low risk, abuse and risk of dependence) based on their total raw scores on the AUDIT questionnaire. Results showed a high prevalence of risk of alcohol dependence in GD patients who were immigrants, unemployed, and had a low level of education. A positive linear trend was also found between alcohol consumption level and the prevalence of other current and life‐time comorbid mental disorders, and for the presence of drug abuse. Statistically significant differences were found between the three alcohol consumption groups in terms of the evolution and severity of the gambling disorder, self‐directedness personality trait, and levels of general psychopathology, hostility and paranoid ideation. In conclusion, the results showed an association between increased alcohol consumption and greater dysfunction.
Erythrocyte sedimentation rate and C‐reactive protein to monitor treatment outcomes in diabetic foot osteomyelitis
Authors: van Asten Suzanne AV , Jupiter Daniel C , Mithani Moez , La Fontaine Javier , Davis Kathryn E , Lavery Lawrence A 
Published: March 2016

AbstractThis study sought to evaluate the effectiveness of the inflammatory markers, erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP), in monitoring treatment of osteomyelitis in the diabetic foot. We screened 150 charts of patients admitted to our hospital with diabetic foot osteomyelitis (DFO), confirmed by positive results of bone culture and/or histopathology. We included patients who had an initial ESR/CRP within 72 hours of admission and two reported follow‐up values. We dichotomised patients based on the outcomes wound healing, re‐infection, recurrent ulceration, re‐hospitalisation, additional surgery, re‐amputation and death, all within 12 months, and analysed the trajectories of the markers over time. Our primary outcome, DFO remission, was defined as wound healing within 12 months of follow‐up without re‐infection. We included 122 subjects; 65 patients (53·3%) had a combination of positive culture and histopathology. Factors associated with DFO remission (n = 46) were a lower white blood count (WBC) at admission (P = 0·006) and a higher glomerular filtration rate (GFR, P = 0·049). Factors associated with healing were a lower WBC (P = 0·004), a higher GFR (P = 0·01), longer wound duration before admission (P = 0·01), location of the ulcer on the great toe (P = 0·01) and higher glycated haemoglobin (P = 0·03). Logistic regression analysis demonstrated no associations between DFO remission and other variables collected. Trajectories of the inflammatory markers showed an association between stagnating values of ESR and CRP and poor clinical outcomes. In this study population, the trajectories of both ESR and CRP during 12 months follow‐up suggest a predictive role of both inflammatory markers when monitoring treatment of DFO.
Family, Peer, and Pubertal Determinants of Dating Involvement Among Adolescents
Authors: Low Sabina , Shortt Joann Wu 
Published: March 2016

This study examines the influence of family, peer, and biological contributors to dating involvement among early adolescents (11–14 years of age; n = 244). Further, we assess how parental monitoring may be modified by pubertal maturation and older sibling risky behavior. Data on delinquent peer affiliation, pubertal maturation, parental monitoring, older sibling risky behavior, and dating involvement were gathered through observations and surveys from adolescents, mothers, older siblings, and teachers. Results indicate that lower levels of parental monitoring and higher levels of older sibling risky behavior were related to adolescents' dating involvement through delinquent peer affiliation. Pubertal maturation was directly related to dating involvement for early daters. Findings emphasize the value of examining social and biological factors, in concert, over time.
Effects of multistrain probiotics on growth performance, nutrient digestibility, blood profiles, faecal microbial shedding, faecal score and noxious gas emission in weaning pigs
Authors: Lan R. X. , Lee S. I. , Kim I. H. 
Published: March 2016

SummaryThis experiment was conducted to investigate the efficacy of multistrain probiotics in weaning pigs. A total of 125 28‐day‐old weaning pigs [(Landrace × Yorkshire) × Duroc] with an initial average body weight (BW) of 7.26 ± 0.76 kg were randomly allotted into 5 treatments, 5 replicate pens/treatment with 5 pigs/pen for 42‐day experiment. Dietary treatments were as follows: CON, basal diet; PC1, CON + 0.01% multistrain probiotics; PC2, CON + 0.03% multistrain probiotics; PC3, CON + 0.06% multistrain probiotics; PC4, CON + 0.1% multistrain probiotics. On day 14, pigs fed the PC4 diet had higher BW gain than pigs fed the CON diet. On day 42, pigs fed multistrain probiotics supplementation diets had higher BW gain than pigs fed the CON diet. From days 1 to 14, pigs fed the PC2, PC3 and PC4 diets had higher (p < 0.05) ADG than pigs fed the CON diet. From day 15 to 42, pigs fed the multistrain probiotics supplementation diets had higher (p < 0.05) average daily gain (ADG) and gain: feed ratio (G:F) than pigs fed the CON diet. In the overall period, pigs fed the multistrain probiotics supplementation diets had higher (p < 0.05) ADG and pigs fed the PC2 and PC4 diets had higher (p < 0.05) G:F than pigs fed the CON diet. On day 42, pigs fed the PC4 diet had higher (p < 0.05) apparent total tract digestibility (ATTD) of dry matter (DM), nitrogen (N) and gross energy (GE), faecal Lactobacillus counts and lower (p < 0.05) E. coli counts and NH3 emission than pigs fed the CON diet. Pigs fed the multistrain probiotics supplementation diets had lower (p < 0.05) H2S and total mercaptans emissions than pigs fed the CON diet. Conclusions, dietary supplementation with 0.1% probiotics improved growth performance, nutrition digestibility and intestinal microflora balance and decreased faecal noxious gas emissions in weaning pigs.
New Constellations of Difference in Europe's 21st‐Century Museumscape
Authors: Macdonald Sharon 
Published: March 2016

AbstractThis article addresses some of the recent, ongoing, and planned reconfigurations of museums in Europe in light of their implications for the making of cultural difference, diversity, and citizenship. It argues that these are configured not only through the internal content of particular museums but also through divisions of classificatory labor and hierarchies of value between kinds of museums and their locations within cities and within nations—that is, through constellations of difference within museumscapes. It examines this in relation to examples of planned and realized new museums, including of Europe, national history, and world museums. Particular attention is given here to the fate of ethnographic or ethnological museums—museums that have had especially significant places in the coordination of difference and identity—and to the consequences of this within shifting grounds of belonging and cultural citizenship. The article then discusses some potential consequences of museum configuration within one city by looking at plans for reconfiguring Berlin's museumscape, especially in relation to the Humboldt Forum, in reconstructed facades of a former palace in the center of the urban and national museumscape.
On Not Showing Scalps: Human Remains and Multisited Debate at the National Museum of Denmark
Authors: Marselis Randi 
Published: March 2016

AbstractMuseums are increasingly taking the cultural values of source communities into account in their representational strategies, and that means that they now face the challenge of explaining to their publics how social responsibility toward distant source communities informs the choices each museum makes. This article examines how the National Museum of Denmark attempted to inform and discuss with the Danish public the museum's decision to not exhibit scalps in their temporary exhibition on Native American culture,Powwow: We Dance, We're Alive. Building on the new, contingent museum ethics proposed by Janet Marstine, the editor of theRoutledge Companion to Museum Ethics, I show how the museum succeeded in engaging users in questions of museum ethics. However, this specific debate on human remains in museums developed into an encounter between a global, museological discourse on the responsibility of museum institutions toward indigenous groups and a common discourse in Danish political debates that views consideration toward the sensibilities of specific ethnic groups as a threat toward free speech and rational knowledge.
Novel calcium infusion regimen after parathyroidectomy for renal hyperparathyroidism
Authors: Tan Jih Huei , Tan Henry Chor Lip , Loke Seng Cheong , Arulanantham Sarojah A/P 
Published: March 2016

AbstractAimCalcium infusion is used after parathyroid surgery for renal hyperparathyroidism to treat postoperative hypocalcaemia. We compared a new infusion regimen to one commonly used in Malaysia based on 2003 K/DOQI guidelines.MethodsRetrospective data on serum calcium and infusion rates was collected from 2011–2015. The relationship between peak calcium efflux (PER) and time was determined using a scatterplot and linear regression. A comparison between regimens was made based on treatment efficacy (hypocalcaemia duration, total infusion amount and time) and calcium excursions (outside target range, peak and trough calcium) using bar charts and an unpaired t‐test.ResultsFifty‐one and 34 patients on the original and new regimens respectively were included. Mean PER was lower (2.16 vs 2.56 mmol/h; P = 0.03) and occurred earlier (17.6 vs 23.2 h; P = 0.13) for the new regimen. Both scatterplot and regression showed a large correlation between PER and time (R‐square 0.64, SE 1.53, P < 0.001). The new regimen had shorter period of hypocalcaemia (28.9 vs 66.4 h, P = 0.04), and required less calcium infusion (67.7 vs 127.2 mmol, P = 0.02) for a shorter duration (57.3 vs 102.9 h, P = 0.001). Calcium excursions, peak and trough calcium were not significantly different between regimens. Early postoperative high excursions occurred when the infusion was started in spite of elevated peri‐operative calcium levels.ConclusionThe new infusion regimen was superior to the original in that it required a shorter treatment period and resulted in less hypocalcaemia. We found that early aggressive calcium replacement is unnecessary and raises the risk of rebound hypercalcemia.
Functional total anomalous pulmonary venous connection via levoatriocardinal vein
Authors: Hayashi Taiyu , Ozawa Katsusuke , Sugibayashi Rika , Wada Seiji , Ono Hiroshi 
Published: March 2016

AbstractWe report a fetal case of double outlet right ventricle, mitral atresia, and intact atrial septum. Although the pulmonary veins were connected to the left atrium, pulmonary venous blood drained into the right superior vena cava via the stenotic levoatriocardinal vein (LACV), which resulted in a circulation resembling total anomalous pulmonary venous connection (TAPVC) with pulmonary venous obstruction. Since the pulmonary veins were connected to both the stenotic LACV and the “dead‐end” left atrium, the pulmonary venous flow had a to‐and‐fro pattern along with atrial relaxation and contraction. Postnatal echocardiography and computed tomography confirmed the diagnosis of normally connected but anomalously draining pulmonary veins via the LACV. Surgical creation of an atrial septal defect on the day of birth successfully relieved pulmonary venous obstruction. Normally connected but anomalously draining pulmonary veins via the LACV should be considered for TAPVC differential diagnosis in fetuses with a left‐side heart obstruction.
Lifetime and 12‐Month Nonsuicidal Self‐Injury and Academic Performance in College Freshmen
Authors: Kiekens Glenn , Claes Laurence , Demyttenaere Koen , Auerbach Randy P. , Green Jennifer G. , Kessler Ronald C. , Mortier Philippe , Nock Matthew K. , Bruffaerts Ronny 
Published: March 2016

We examined whether nonsuicidal self‐injury (NSSI) is associated with academic performance in college freshmen, using census‐based web surveys (N = 7,527; response = 65.4%). NSSI was assessed with items from the Self‐Injurious Thoughts and Behaviors Interview and subsequently linked with the administratively recorded academic year percentage (AYP). Freshmen with lifetime and 12‐month NSSI showed a reduction in AYP of 3.4% and 5.9%, respectively. The college environment was found to moderate the effect of 12‐month NSSI, with more strongly reduced AYPs in departments with higher‐than‐average mean departmental AYPs. The findings suggest that overall stress and test anxiety are underlying processes between NSSI membership and academic performance.
B‐cell lymphoma with Mott cell differentiation in a cat
Authors: Kanehara Tomomi , Matsui Naoko , Murakami Mami , Maruo Kohji , Mori Takashi , Hirata Akihiro , Yanai Tokuma , Sakai Hiroki 
Published: March 2016

AbstractA 12‐year‐old, male castrated Domestic Shorthair cat was presented to Animal Medical Center of Gifu Univeristy with anorexia and vomiting. Physical examination revealed an enlarged left tonsil and right mandibular lymph node (approximately 2–3× the normal size), and a submucosal mass on the right side of the epiglottis (1.5 × 2.0 cm). On computed tomography images, an enlarged left tonsil, and enlarged right mandibular, right pharyngeal, and left and right cervical lymph nodes were observed. Cytologic examination of smears of tonsil and lymph nodes revealed numerous medium‐ to large‐sized neoplastic lymphoid cells, approximately half of which contained one or several light‐blue homogenous globoid cytoplasmic inclusions (5–10 μm), which stained magenta with periodic acid–Schiff (PAS) stain. Histopathologic examination of the left tonsil revealed diffuse proliferation of medium‐ to large‐sized neoplastic lymphoid cells effacing the original lymphoid architecture. Half of the cells contained one or several eosinophilic globoid cytoplasmic inclusions, which stained magenta with PAS and showed positive immunohistochemical reactions for immunoglobulin M (IgM) and λ light chain. Neoplastic lymphoid cells were also CD20+, Pax5+, and MUM1+, and CD3−. Thus, the neoplastic lymphoid cells expressed a B‐cell immunophenotype, and the globoid cytoplasmic inclusions represented an aberrant IgM λ light chain accumulation, similar to Russell bodies. B‐cell lymphoma with Mott cell differentiation was diagnosed based on cytologic, histopathologic, and immunohistochemical features. This is the first report of B‐cell lymphoma with Mott cell differentiation in a cat.
Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V‐ATPase generated voltage gradient as the driving force
Authors: Zhong Xi Zoë , Cao Qi , Sun Xue , Dong Xian‐Ping 
Published: March 2016

Key points
SLC17A9 proteins function as a lysosomal ATP transporter responsible for lysosomal ATP accumulation.
P2X4 receptors act as lysosomal ion channels activated by luminal ATP.
SLC17A9‐mediated ATP transport across the lysosomal membrane is suppressed by Bafilomycin A1, the V‐ATPase inhibitor.
SLC17A9 mainly uses voltage gradient but not pH gradient generated by the V‐ATPase as the driving force to transport ATP into the lysosome to activate P2X4.
AbstractThe lysosome contains abundant ATP which plays important roles in lysosome functions and in cell signalling. Recently, solute carrier family 17 member 9 (SLC17A9, also known as VNUT for vesicular nucleotide transporter) proteins were suggested to function as a lysosomal ATP transporter responsible for lysosomal ATP accumulation, and P2X4 receptors were suggested to be lysosomal ion channels that are activated by luminal ATP. However, the molecular mechanism of SLC17A9 transporting ATP and the regulatory mechanism of lysosomal P2X4 are largely unknown. In this study, we report that SLC17A9‐mediated ATP transport across lysosomal membranes is suppressed by Bafilomycin A1, the V‐ATPase inhibitor. By measuring P2X4 activity, which is indicative of ATP transport across lysosomal membranes, we further demonstrated that SLC17A9 mainly uses voltage gradient but not pH gradient as the driving force to transport ATP into lysosomes. This study provides a molecular mechanism for lysosomal ATP transport mediated by SLC17A9. It also suggests a regulatory mechanism of lysosomal P2X4 by SLC17A9.