bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unintended readmissions and reoperations within 30 and 90 days following adult spinal deformity surgery
Authors: Seo Seung-Ho , Hyun Seung-Jae , Lee Jae-Koo , Kim Ki-Jeong 
Published: October 2024

OBJECTIVE
This study investigated the rates and etiologies of unintended readmissions and reoperations within 30 and 90 days after adult spinal deformity (ASD) surgery. The authors aimed to identify the risk factors for readmission and reoperation by analyzing patient demographic and surgical characteristics.

METHODS
This retrospective cohort study included 307 consecutive patients who underwent surgery for ASD from 2012 to 2022 at a single academic institution. Data were collected on patient demographic characteristics, comorbidities, operative details, and postoperative complications. Chi-square and multivariable logistic regression models were used to identify the risk factors associated with 30- and 90-day readmissions and reoperations.

RESULTS
The mean ± SD age at surgery was 66.6 ± 10.5 years, and the majority (80.8%) of patients were female. The 30-day and 90-day readmission rates were 11.7% and 15.3%, respectively. Multivariable regression for 30-day readmissions revealed that length of hospital stay (LOS) after index surgery of > 20 days (OR 2.48) and surgical factors such as vertebral column resection (VCR) (OR 4.26) and pelvic fixation (OR 4.38) were risk factors. Other factors such as the American Society of Anesthesiologists Physical Status Classification System (ASA) class, prior spine surgery, and age were not associated with 30-day readmissions. Ninety-day readmission was associated with high ASA class (OR 2.37) and LOS > 20 days (OR 2.82). The 30- and 90-day reoperation rates were 7.8% and 10.1%, respectively. The variables associated with 30-day reoperations were intraoperative VCR (OR 3.34) and LOS > 20 days (OR 9.38). Ninety-day reoperations were associated with dural tears (OR 3.33) and LOS > 20 days (OR 3.68).

CONCLUSIONS
This study provides valuable insights into the incidence of unintended readmission and reoperation within 30 and 90 days after ASD surgery in an Asian population. By identifying the associated risk factors, healthcare providers can customize surgical strategies and optimize perioperative care to effectively mitigate these events.
Identificación de analogías de pertenencia e inclusión en adultos jóvenes
Authors: Parra Cuamba Imelda , Villuendas González Erwin Rogelio 
Published: October 2024

Current research data on identifying analogies between word pairs has often overlooked the implications of the type of relations used. However, although the identification of different types of relations clearly involves distinct processes, not enough attention has been given to the identification of these differences. This study aimed to compare two semantic relations (analogies of belonging and inclusion) regarding the accuracy and response time in identification. 79 college students (age 18-26) participated. Data analysis revealed a better performance and reduced response time to detect analogies of the belonging type. The theoretical implications of these findings are discussed.
Analysis of Post-agonism Reconciliation in a Captive Group of the Wedge-Capped Capuchin Monkey, Cebus olivaceus: a Pilot Study.
Authors: Tárano Zaida , Flores Ruth Marina 
Published: October 2024

Agonism was often associated to an increase in inter-individual distances in social individuals; however, many evidences indicate that individuals affiliate after a dispute ( “reconciliate”). The post-agonism behavior of individuals in a captive troop of the wedge-capped capuchin monkey was described and conciliatory tendency (CT) was estimated by using the PC-MC (Post-Conflict – Matched Control) method; here PA-MC (Post-Agonism – Matched-Control). Males initiated more agonistic interactions toward females than to other males while females avoided initiating them toward males. Interestingly, females were more prone to initiate reconciliation than males, both toward males (CT: 0.20-0.42) and toward other females (CT: 0.24-0.25). Overall, the CT in the group ranged from 0.127 to 0.198. We compared our results with those from other capuchins and propose that reconciliation may not be fundamental in maintaining social cohesion in Cebidae; nonetheless, due to our small sample, this is a preliminary conclusion.
Faria de Vasconcelos: um pioneiro no movimento da Escola Nova na Europa e na América Latina
Authors: Sousa Machado Teresa 
Published: October 2024

The relevance of education, namely the education of children, during the period of the installation of Republic in Portugal, in 1910, takes on a particular role that moves many authors, such as doctors, educators, professors and politicians. It was believed that all (the social problems) could be arranged through school-education, forgetting the individual and social factors (out of control). Among others, Faria de Vasconcelos is a portuguese that stands out in Portugal, in the rest of Europe and in Latin America. In line with republican reforms, advocates education for all, and implements numerous projects, of which we report here the twelve lessons of pedagogy and pedology, in the spirit of Escola Nova, that lead to the foundation of the Bierges-les-Wavre school (Belgium) which makes history in psychology. His lessons portray great critical knowledge of psychological’ thesis of the first decades of XXth century, become themselves a testimony of psychology and pedagogy. We also report his contribution to adult education, as innovative and representing the urgency to accomplish a reform of Portuguese mentality, throughout education.Key Words:
Integrating session recording and eye-tracking: development and evaluation of a Chrome extension for user behavior analysis
Authors: Zelinskyi Serhii , Boyko Yuriy 
Published: October 2024

The subject of this article is the development, implementation, and evaluation of a Chrome extension designed to record and replay web sessions using integrated eye-tracking data. The goal is to develop a tool that enhances user interaction analysis by combining session recordings with eye-tracking capabilities. The tasks to be solved are as follows: create a functional Chrome extension that utilizes rrweb for session recording and WebGazer.js for eye tracking; implement features, such as session recording, replay with eye-tracking data overlays, and session management; and provide options for exporting and importing recorded sessions. The methods used are: architectural modeling using UML diagrams to design the system architecture, software engineering techniques for developing the extension, integration testing to ensure the smooth operation of combined features, and data preprocessing techniques to prevent redundancy and reduce noise in eye-tracking data. Additionally, a structured user study with detailed questionnaires combining both Likert-scale questions and open-ended responses and feedback analysis were conducted to evaluate usability and gather feedback. The following results were obtained: the extension was successfully developed and evaluated with 25 participants aged 18–35 years in a controlled environment. High usability ratings were obtained, with an average score of 4.5 out of 5 for the session recording, replay, and session management features. However, the eye-tracking feature received a lower rating of 3.8 out of 5 due to occasional inaccuracies in the eye-tracking data. The qualitative feedback indicated the usefulness of the eye-tracking feature and highlighted the need for improved data accuracy. Conclusions. The scientific novelty of this study lies in the integration of session recording and eye tracking within a Chrome extension, which represents a novel and comprehensive tool for user interaction analysis on the web. The tool's ability to capture both behavioral data and visual attention without requiring website code modifications is particularly valuable for researchers, marketing specialists, UI/UX designers, and product developers. The usability study and feedback analysis provided a clear direction for future improvements, including enhancing the eye-tracking accuracy and integrating advanced analytics and customizable reporting options. Future work will also explore the integration of machine learning algorithms to automatically analyze recorded data to provide deeper insights and actionable recommendations.
Gambaran Tingkat Stres dan Pola Makan pada Penderitagastritis di Puskesmas Tanjung Paku Kota Solok Tahun 2024
Authors: Mirawati Anita , Apriliani Indah , Zulharmaswita Zulharmaswita , Deswita Desi 
Published: October 2024

Gastritis adalah peradangan pada mukosa lambung yang disertai kerusakan atau erosi pada mukosa, berdasarkan data angka kejadian gastritis di seluruh puskesmas di Kota Solok selama setahun adalah 538 penderita, Puskesmas dengan penderita yang paling tinggi adalah Puskesmas Tanjung Paku dengan jumlah penderita yaitu sebanyak 222 penderita. Tujuan penelitian ini untuk mendeskripsikan bagaimana gambaran tingkat stres dan pola makan penderita gastritis di Puskesmas Tanjung Paku Kota Solok Tahun 2023. Desain penelitian ini adalah deskriptif yang bertujuan untuk mengetahui gambaran tingkat stres dan pola makan yang berperan dalam mempengaruhi kejadian gastritis di Puskesmas Tanjung Paku Kota Solok Tahun. Tempat penelitian di Puskesmas Tanjung Paku Kota Solok. Subjeknya yaitu pasien yang telah di diagnosa Gastritis sebanyak 40 orang. Waktu penelitian selama 14 hari dimulai tanggal 15-26 April 2024.Hasil penelitian ini menunjukkan bahwa penderita gastritis memiliki tingkat stres ringan sebagian kecil (45,0%) dan pola makan yang kurang baik sebagian besar (57,5%). Penderita Gastritis biasanya dianjurkan untuk menerapkan diet lambung/gastritis. Tujuan diberikannya diet lambung diantarannya menetralkan kelebihan asam lambung dengan memberikan makanan yang adekuat dan tidak merangsang. Penelitian ini diharapkan dapat bermanfaat sebagai bahan informasi dan pengetahuan mengenai stres dan pola makan yang dapat menyebabkan gastritis, sehingga dapat digunakan untuk referensi dalam mengembangkan ilmu pengetahuan dan acuan pengembangan penelitian dalam praktik keperawatan medikal bedah.
Apoptosis, inflammatory and innate immune responses induced by infection with a novel goose astrovirus in goose embryonic kidney cells
Authors: Hou Zhanpeng , Jin Shaobing , Liang Yu , Wang Haiyue , Jiang Danli , Cao Nan , Sun Minhua , Tian Yunbo , Liu Wenjun , Xu Danning , Fu Xinliang 
Published: October 2024

IntroductionSince 2016, a highly lethal visceral gout induced by infection with the novel goose astrovirus (GoAstV) resulted in an ongoing outbreak in goslings in China, with a mortality rate ranging from 10% to 50%, and causing considerable economic losses in the goose industry. However, the pathogenesis of GoAstV and the molecular mechanism by which kidney lesions are induced by GoAstV infection are unclear.MethodsIn the present study, a GEK cell infection model for GoAstV was established, and the apoptosis, inflammatory and innate immune responses induced by GoAstV were investigated in GEK cells.ResultsThe results shown that the expression of proapoptotic proteins, including Bax, caspase-3, caspase-9 and cytochrome c, increased in the infection group; however, the expression of the antiapoptotic protein Bcl-2 decreased, indicating that apoptosis was induced by GoAstV infection in GEK cells. Besides, the activation of the RIG-I/MDA5 pathway and the downstream upregulation of proinflammatory cytokines, including the adapter proteins MAVS, IRF7 and NF-κB and the proinflammatory cytokines IL-6, IL-8 and TNF-α, were detected in GEK cells infected with GoAstV. In addition, GoAstV infection induces the activation of the NLPR3 pathway and further stimulates the increased production of IL-1β. In summary, the present study revealed that GoAstV infection could induce apoptosis and the activation of the RIG-I/MDA5 and NLRP3 pathways in GEK cells, as well as the massive release of proinflammatory cytokines.DiscussionThese results are helpful for elucidating the molecular mechanism of pathological lesions in the kidney in gout goslings infected with GoAstV and the interaction between GoAstV and the innate immune system of the host.
Genomic epidemiology and evolutionary dynamics of the Omicron variant of SARS-CoV-2 during the fifth wave of COVID-19 in Pakistan
Authors: Razzaq Aroona , Disoma Cyrollah , Iqbal Sonia , Nisar Ayesha , Hameed Muddassar , Qadeer Abdul , Waqar Muhammad , Mehmood Sardar Azhar , Gao Lidong , Khan Sawar , Xia Zanxian 
Published: October 2024

IntroductionThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed extraordinary challenges to global health systems and economies. The virus’s rapid evolution has resulted in several variants of concern (VOCs), including the highly transmissible Omicron variant, characterized by extensive mutations. In this study, we investigated the genetic diversity, population differentiation, and evolutionary dynamics of the Omicron VOC during the fifth wave of COVID-19 in Pakistan.MethodsA total of 954 Omicron genomes sequenced during the fifth wave of COVID-19 in Pakistan were analyzed. A Bayesian framework was employed for phylogenetic reconstructions, molecular dating, and population dynamics analysis.ResultsUsing a population genomics approach, we analyzed Pakistani Omicron samples, revealing low within-population genetic diversity and significant structural variation in the spike (S) protein. Phylogenetic analysis showed that the Omicron variant in Pakistan originated from two distinct lineages, BA.1 and BA.2, which were introduced from South Africa, Thailand, Spain, and Belgium. Omicron-specific mutations, including those in the receptor-binding domain, were identified. The estimated molecular evolutionary rate was 2.562E-3 mutations per site per year (95% HPD interval: 8.8067E-4 to 4.1462E-3). Bayesian skyline plot analysis indicated a significant population expansion at the end of 2021, coinciding with the global Omicron outbreak. Comparative analysis with other VOCs showed Omicron as a highly divergent, monophyletic group, suggesting a unique evolutionary pathway.ConclusionsThis study provides a comprehensive overview of Omicron’s genetic diversity, genomic epidemiology, and evolutionary dynamics in Pakistan, emphasizing the need for global collaboration in monitoring variants and enhancing pandemic preparedness.
The role of circulating cytokines in heart failure: a bidirectional, two-sample Mendelian randomization study
Authors: Zheng Haoran , Mao Xinxin , Fu Zhenyue , Chen Chunmei , Lv Jiayu , Wang Yajiao , Wang Yuxin , Wu Huaqin , Li Yvmeng , Tan Yong , Gao Xiya , Zhao Lu , Xu Xia , Zhang Bingxuan , Song Qingqiao 
Published: October 2024

BackgroundCytokines play a pivotal role in the progression of heart failure (HF) by modulating inflammatory responses, promoting vasoconstriction, and facilitating endothelial injury. However, it is now difficult to distinguish the causal relationship between HF and cytokines in observational studies. Mendelian randomization (MR) analyses of cytokines probably could enhance our comprehension to the underlying biological processes of HF.MethodsThis study was to explore the correlation between 41 cytokines with HF at the genetic level by MR analysis. We selected a HF dataset from the Heart Failure Molecular Epidemiology for Therapeutic Targets (HERMES) 2018 and a cytokine dataset from a meta-analysis of cytokine levels in Finns. Two-sample, bidirectional MR analyses were performed using Inverse Variance Weighted (IVW), Weighted Median and MR- egger, and the results were tested for heterogeneity and pleiotropy, followed by sensitivity analysis.ResultsGenetic prediction of high levels of circulating Macrophage inflammatory pro-tein-1β(MIP-1β) (P = 0.0389), Interferon gamma induced protein 10(IP-10) (P = 0.0029), and Regu-lated on activation, normal T cell expressed and secreted(RANTES) (P = 0.0120) expression was associated with an elevated risk of HF. HF was associated with the increased levels of circulating Interleukin-2 receptor, alpha subunit(IL-2ra) (P = 0.0296), Beta nerve growth fac-tor(β-NGF) (P = 0.0446), Interleukin-17(IL-17) (P = 0.0360), Basic fibroblast growth factor(FGF-basic) (P = 0.0220), Platelet derived growth factor BB(PDGF-BB) (P = 0.0466), and Interferon-gamma(IFN-γ) (P = 0.0222); and with decreased levels of Eotaxin (P = 0.0133). The heterogeneity and pleiotropy of the cytokines were acceptable, except for minor heterogeneity of FGF-basic and IL-17.ConclusionThese findings provide compelling evidence for a genetically predictive relationship between cytokines and HF, emphasizing a great potential of targeted modulation of cytokines in slowing the progression of HF. This study draws further conclusions at the genetic level, providing a basis for future large-scale clinical trials.
Safety and efficacy of DEB-TACE in combination with lenvatinib and camrelizumab for the treatment of unresectable hepatocellular carcinoma (uHCC): a two-centre retrospective study
Authors: Xuexian Zhang , Ruidong Wang , Yuhan Ding , Qingwei Li , Feng Xiong , Hong Ren , Jun Zhang , Wei Li 
Published: October 2024

ObjectivesThe purpose of this study was to compare the safety and efficacy of drug-eluting bead (DEB) transarterial chemoembolization combined with lenvatinib and camrelizumab (DEB-TACE-Len-C) and DEB-TACE-Len for the treatment of unresectable hepatocellular carcinoma (uHCC).MethodsThis retrospective study consecutively included uHCC patients who underwent DEB-TACE-Len-C or DEB-TACE-Len treatment at our hospital and Qujing Second People’s Hospital from April 2020 to April 2022. In total, 85 patients were enrolled. There were 42 patients in the DEB-TACE-Len-C group and 43 patients in the DEB-TACE-Len group. The disease control rate (DCR), objective response rate (ORR), overall survival (OS), progression-free survival (PFS), and adverse events (AEs) were compared between the two groups, and the factors influencing OS and PFS were analysed.ResultsThe ORR, DCR, PFS and OS were significantly greater in the DEB-TACE-Len-C group than in the DEB-TACE-Len group (ORR: 76.2% vs. 46.5%, P = 0.005; DCR: 88.1% vs. 67.8%, P = 0.039; PFS: 10 months vs. 6 months, P &lt;0.0001; OS: 24 months vs. 16 months, P = 0.0038). Multivariate Cox proportional hazard regression analysis revealed that portal tumour thrombus (PVTT) and therapeutic approach were independent factors affecting PFS and OS. There were no statistically significant differences in the incidence of AEs between the two groups (P &gt; 0.05).ConclusionCompared with DEB-TACE-Len, DEB-TACE-Len-C is an effective treatment option that can improve the tumour therapeutic response and prolong the OS and PFS in uHCC patients.
Acute-phase innate immune responses in SIVmac239-infected Mamu-B*08+ Indian rhesus macaques may contribute to the establishment of elite control
Authors: Rosen Brandon C. , Sawatzki Kaitlin , Ricciardi Michael J. , Smith Elise , Golez Inah , Mauter Jack T. , Pedreño-López Núria , Yrizarry-Medina Aaron , Weisgrau Kim L. , Vosler Logan J. , Voigt Thomas B. , Louw Johan J. , Tisoncik-Go Jennifer , Whitmore Leanne S. , Panayiotou Christakis , Ghosh Noor , Furlott Jessica R. , Parks Christopher L. , Desrosiers Ronald C. , Lifson Jeffrey D. , Rakasz Eva G. , Watkins David I. , Gale Michael 
Published: October 2024

IntroductionSpontaneous control of chronic-phase HIV/SIV viremia is often associated with the expression of specific MHC class I allotypes. HIV/SIV-specific CD8+ cytotoxic T lymphocytes (CTLs) restricted by these MHC class I allotypes appear to be critical for viremic control. Establishment of the elite controller (EC) phenotype is predictable in SIVmac239-infected Indian rhesus macaques (RMs), with approximately 50% of Mamu-B*08+ RMs and 20% of Mamu-B*17+ RMs becoming ECs. Despite extensive characterization of EC-associated CTLs in HIV/SIV-infected individuals, the precise mechanistic basis of elite control remains unknown. Because EC and non-EC viral load trajectories begin diverging by day 14 post-infection, we hypothesized that hyperacute innate immune responses may contribute to viremic control.MethodsTo gain insight into the immunological factors involved in the determination of EC status, we vaccinated 16 Mamu-B*08+ RMs with Vif and Nef to elicit EC-associated CTLs, then subjected these 16 vaccinees and an additional 16 unvaccinated Mamu-B*08+ controls to repeated intrarectal SIVmac239 challenges. We then performed whole-blood transcriptomic analysis of all 32 SIVmac239-infected Mamu-B*08+ RMs and eight SIVmac239-infected Mamu-B*08– RMs during the first 14 days of infection.ResultsVaccination did not provide protection against acquisition, but peak and setpoint viremia were significantly lower in vaccinees relative to controls. We did not identify any meaningful correlations between vaccine-induced CTL parameters and SIVmac239 acquisition rate or chronic-phase viral loads. Ultimately, 13 of 16 vaccinees (81%) and 7 of 16 controls (44%) became ECs (viremia ≤ 10,000 vRNA copies/mL plasma for ≥ 4 weeks). We identified subsets of immunomodulatory genes differentially expressed (DE) between RM groupings based on vaccination status, EC status, and MHC class I genotype. These DE genes function in multiple innate immune processes, including the complement system, cytokine/chemokine signaling, pattern recognition receptors, and interferon-mediated responses.DiscussionA striking difference in the kinetics of differential gene expression among our RM groups suggests that Mamu-B*08-associated elite control is characterized by a robust, rapid innate immune response that quickly resolves. These findings indicate that, despite the association between MHC class I genotype and elite control, innate immune factors in hyperacute SIV infection preceding CTL response development may facilitate the establishment of the EC phenotype.
Comprehensive evaluation of clinical outcomes in hepatic epithelioid hemangioendothelioma subsets: insights from SEER Database and departmental cohort analysis
Authors: Wang Bingchen , Chen Xiao , Li Rongxuan , Ai Bolun , Ye Feng , Zhao Jianjun , Zhang Yefan , Huang Zhen , Li Zhiyu , Bi Xinyu , Zhao Hong , Cao Dayong , Cai Jianqiang , Zhou Jianguo , Yan Tao 
Published: October 2024

BackgroundEpithelioid hemangioendothelioma (EHE), is an uncommon, intermediate-grade malignant vascular tumor that can manifest in diverse organs, including the liver, lungs, and bones. Given its unique malignancy profile and rarity, there lacks a consensus on a standardized treatment protocol for EHE, particularly for hepatic epithelioid hemangioendothelioma (HEHE). This study aims to elucidate factors influencing the clinical prognosis of EHE by analyzing data from the SEER database, complemented with insights from a departmental cohort of 9 HEHE cases. Through this, we hope to shed light on potential clinical outcomes and therapeutic strategies for HEHE.MethodsUsing SEER data from 22 registries, we analyzed 313 liver cancer patients with ICD-O-3 9130 and 9133 histology. Twelve variables were examined using Cox regression and mlr3 machine learning. Significant variables were identified and compared. Clinical data, imaging characteristics, and treatment methods of nine patients from our cohort were also presented.ResultIn univariate and multivariate Cox regression analyses, Age, Sex, Year of diagnosis, Surgery of primary site, Chemotherapy, and Median household income were closely related to survival outcomes. Among the ten survival-related machine learning models, CoxPH, Flexible, Mboost, and Gamboost stood out based on Area Under the Curve(AUC), Decision Curve Analysis(DCA), and Calibration Curve Metrics. In the feature importance analysis of these four selected models, Age and Surgery of primary site were consistently identified as the most critical factors influencing prognosis. Additionally, the clinical data of nine patients from our cohort not only demonstrated unique imaging characteristics of HEHE but also underscored the importance of surgical intervention.ConclusionFor patients with resectable HEHE, surgical treatment is currently a highly important therapeutic approach.