bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disposable Sandwich‐type Electrochemical Sensor for Selective Detection of Glucose Based on Boronate Affinity
Authors: Li Jian , Bai Zhanming , Mao Yanjun , Sun Qingqing , Ning Xiaohui , Zheng Jianbin 
Published: July 2017

AbstractA disposable sandwich‐type electrochemical sensor for selective detection of glucose was established. The primary receptor, 3‐aminophenylboronic acid was grafted covalently onto the surface of screen‐printed carbon electrodes through an in situ‐generated diazo‐reaction. Glucose was first captured by boronic acid group on the electrode, followed by captureing an electroactive ferroceneboronic acid (FcBA) as the secondary receptor to form bidentate glucose‐boronic complex. Electrochemical impedance spectroscopy was applied to characterize the construction of sandwich‐type disposable sensor. In the sandwich assay, current response of captured FcBA on the electrode was dependent on the concentration of glucose. The sandwich assay showed higher selectivity for glucose than that for fructose, mannose, galactose and other electroactive interferences including uric acid, ascorbic acid and dopamine, and exhibited a dynamic concentration range of glucose from 0.5 to 20.0 mmol L−1. The disposable sensor demonstrated a good reproducibility with 2.2 % relative standard deviation (RSD). In addition, the disposable glucose sensor was used in detection of the trace glucose in the clinical urine samples.
Subtypes of Personality and ‘Locus of Control’ in Bariatric Patients and their Effect on Weight Loss, Eating Disorder and Depressive Symptoms, and Quality of Life
Authors: Peterhänsel Carolin , Linde Katja , Wagner Birgit , Dietrich Arne , Kersting Anette 
Published: July 2017

AbstractThe present study subdivided personality types in a bariatric sample and investigated their impact on weight loss and psychopathology 6 and 12 months after surgery. One hundred thirty participants answered questionnaires on personality (NEO‐FFI), ‘locus of control’ (IPC), depression severity (BDI‐II), eating disorder psychopathology (EDE‐Q), and health‐related quality of life (HRQoL; SF‐12). K‐means cluster analyses were used to identify subtypes. Two subtypes emerged: an ‘emotionally dysregulated/undercontrolled’ cluster defined by high neuroticism and external orientation and a ‘resilient/high functioning’ cluster with the reverse pattern. Prior to surgery, the first subtype reported more eating disorder and depressive symptoms and less HRQoL. Differences persisted regarding depression and mental HRQoL until 12 months after surgery, except in the areas weight loss and eating disorders. Personality seems to influence the improvement or maintenance of psychiatric symptoms after bariatric surgery. Future research could elucidate whether adapted treatment programmes could have an influence on the improvement of procedure outcomes. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Quantitative structure-reactivity relationships of hydroxyl radical rate constants for linear and cyclic volatile methylsiloxanes
Authors: Kim Jaeshin , Xu Shihe 
Published: July 2017

Abstract

An accurate understanding of the fate of volatile methylsiloxanes (VMS) in air is crucial for determining their persistence and concentrations in the environment. Although oxidation by atmospheric hydroxyl radicals (•OH) is considered as a major degradation mechanism for airborne VMS, the existing bimolecular rate constants with •OH measured and modeled for any given VMS compound varied greatly, depending on the approaches used to generate the data. The objectives of the present study were to measure •OH reaction rate constants for 4 cyclic and 4 linear VMS based on a relative rate method using a newly designed atmospheric chamber and to establish structure–reactivity relationships for the kinetics. In the past, the reaction rate constants for VMS were generally recognized to increase with the number of the methyl groups per molecule, the only differential factor in the existing models. However, the new measurements indicated that molecular structure should also be considered in the prediction of the reaction rates. Better empirical models were developed by simple and multiple linear regressions of the measured values from the present study and the literature. A high correlation existed for the reaction rates with the number of the methyl group attached at 2 distinct siloxane structures (i.e., linear and cyclic VMS). Even better correlations were obtained with one or 2 molecular descriptors that are directly related to the size of VMS, which, in turn, not only depend on the number of methyl groups, but the linear/cyclic structures as well for permethylsiloxanes. Environ Toxicol Chem 2017;36:3240–3245. © 2017 SETAC
Photodegradation kinetics, transformation, and toxicity prediction of ketoprofen, carprofen, and diclofenac acid in aqueous solutions
Authors: Li Jian , Ma Li-yun , Li Lu-shuang , Xu Li 
Published: July 2017

Abstract

Photodegradation of 3 commonly used nonsteroidal anti-inflammatory drugs, ketoprofen, carprofen, and diclofenac acid, was conducted under ultraviolet (UV) irradiation. The kinetic results showed that the 3 pharmaceuticals obeyed the first-order reaction with decreasing rate constants of 1.54 × 10−4, 5.91 × 10−5, and 7.78 × 10−6 s−1 for carprofen, ketoprofen, and diclofenac acid, respectively. Moreover, the main transformation products were identified by ion-pair liquid–liquid extraction combined with injection port derivatization-gas chromatography-mass spectrometry and high-performance liquid chromatography-quadrupole-time of flight mass spectrometric analysis. There were 8, 3, and 6 transformation products identified for ketoprofen, carprofen, and diclofenac acid, respectively. Decarboxylation, dechlorination, oxidation, demethylation, esterification, and cyclization were proposed to be associated with the transformation of the 3 pharmaceuticals. Toxicity prediction of the transformation products was conducted on the EPI Suite software based on ECOSAR model, and the results indicate that some of the transformation products were more toxic than the parent compounds. The present study provides the foundation to understand the transformation behavior of the studied pharmaceuticals under UV irradiation. Environ Toxicol Chem 2017;36:3232–3239. © 2017 SETAC
Model identification of reduced order fluid dynamics systems using deep learning
Authors: Wang Z. , Xiao D. , Fang F. , Govindan R. , Pain C. C. , Guo Y. 
Published: July 2017

SummaryThis paper presents a novel model reduction method: deep learning reduced order model, which is based on proper orthogonal decomposition and deep learning methods. The deep learning approach is a recent technological advancement in the field of artificial neural networks. It has the advantage of learning the nonlinear system with multiple levels of representation and predicting data. In this work, the training data are obtained from high fidelity model solutions at selected time levels. The long short‐term memory network is used to construct a set of hypersurfaces representing the reduced fluid dynamic system. The model reduction method developed here is independent of the source code of the full physical system.The reduced order model based on deep learning has been implemented within an unstructured mesh finite element fluid model. The performance of the new reduced order model is evaluated using 2 numerical examples: an ocean gyre and flow past a cylinder. These results illustrate that the CPU cost is reduced by several orders of magnitude whilst providing reasonable accuracy in predictive numerical modelling.
How to achieve benefits from diversity in international alliances: Mechanisms and cultural intelligence
Authors: Pesch Robin , Bouncken Ricarda B. 
Published: July 2017

Research SummaryDespite interest in alliance management in the global strategy field, we have only limited insights into how firms can manage diversity‐related conflicts in international alliances. By referring to the conflict literature, our study introduces task discourse as a crucial mechanism allowing task conflict resolution. We further describe conflict resolution via socializing practices, including social events, joint workshops, and interorganizational teams. Socializing practices and discourse take advantage of cultural intelligence, empowering managers to interact efficiently in intercultural settings. Data on 148 international alliances in the photonics and biotechnology industries reveal that managerial cultural intelligence improves task discourse, thus enhancing performance, especially in young alliances. Socializing practices, however, decrease performance with increasing cultural distance and without sufficient levels of managerial cultural intelligence.Managerial SummaryInternational alliances face a dilemma. Cross‐national differences offer valuable complementarities, but they can also spark a negative spiral of dysfunctional conflict. Our study shows that task discourse is an important mechanism for achieving advantages from the different perspectives offered by international alliances. Interestingly, our results further reveal that socializing practices including interorganizational teams, social events, and joint workshops do not per se have beneficial effects for international alliances. Putting people together who are unable to perform in intercultural settings is damaging to alliance performance. Our study indicates the specific conditions under which socializing practices have negative and positive effects and, thus, provokes a discussion about the appropriate application of these practices.
Overweight is associated with lower resting state functional connectivity in females after eliminating genetic effects: A twin study
Authors: Doornweerd Stieneke , van Duinkerken Eelco , de Geus Eco J. , Arbab‐Zadeh Parniane , Veltman Dick J. , IJzerman Richard G. 
Published: July 2017

AbstractObesity is related to altered functional connectivity of resting state brain networks that are involved in reward and motivation. It is unknown to what extent these associations reflect genetic confounding and whether the obesity‐related connectivity changes are associated with differences in dietary intake. In this study, resting state functional MRI was performed after an overnight fast in 16 female monozygotic twin pairs (aged 48.8 ± 9.8 years) with a mean BMI discordance of 3.96 ± 2.1 kg/m2(range 0.7–8.2). Functional connectivity of the salience, basal ganglia, default mode and anterior cingulate–orbitofrontal cortex networks was examined by independent component analysis. Dietary intake was assessed using 3‐day 24‐hour recalls. Results revealed that within the basal ganglia network, heavier versus leaner co‐twins have decreased functional connectivity strength in bilateral putamen(P < 0.05, FWE‐corrected). There were no differences in connectivity in the other networks examined. In the overall group, lower functional connectivity strength in the left putamen was correlated with higher intake of total fat (P < 0.01). It was concluded that, after eliminating genetic effects, overweight is associated with lower resting state functional connectivity in bilateral putamen in the basal ganglia network. The association between lower putamen connectivity and higher fat intake suggests an important role of the putamen in appetitive mechanisms. The cross‐sectional nature of our study cannot discriminate cause and consequence, but the findings are compatible with an effect of lower putamen connectivity on increased BMI and associated higher fat intake.Hum Brain Mapp 38:5069–5081, 2017. ©2017 Wiley Periodicals, Inc.
The effect of state laws designed to prevent nonmedical prescription opioid use on overdose deaths and treatment
Authors: Popovici Ioana , Maclean Johanna Catherine , Hijazi Bushra , Radakrishnan Sharmini 
Published: July 2017

AbstractNonmedical use of prescription opioids has reached epidemic levels in the United States and globally. In response, federal, state, and local governments are taking actions to address substantial increases in prescription opioid addiction and its associated harms. This study examines the effect of two state laws specifically designed to curtail access to prescription opioids to nonmedical users: pain management clinic and doctor shopping laws. We use administrative data on overdose deaths and admissions to specialty substance use disorder treatment coupled with a differences‐in‐differences design. Our findings suggest that both pain management clinic and doctor shopping laws have the potential to reduce prescription opioid overdose deaths. Moreover, doctor shopping laws appear to reduce prescription opioid treatment admissions. As many states have adopted these laws in recent years, the full effects of the laws may not yet be realized. Future research using more postlaw passage data should reevaluate the effectiveness of these laws.
Association between maternal vascular murmur and the small‐for‐gestational‐age fetus with abnormal umbilical artery Doppler flow
Authors: Riknagel Diana , Farlie Richard , Hedegaard Morten , Humaidan Peter , Struijk Johannes J. 
Published: July 2017

AbstractObjectiveTo investigate the association between maternal vascular murmurs (MVMs) and fetal growth restriction (defined as small‐for‐gestational‐age [SGA] fetus) and abnormal Doppler pulsatility index (PI) of the uterine and/or umbilical arteries.MethodsA cross‐sectional study of women aged 18 years or older with a singleton pregnancy at 28–34 weeks was conducted at Regional Hospital Viborg, Denmark, between May 1 and August 1, 2013. Ultrasound fetal biometry was performed and the Doppler PI of the umbilical and uterine arteries was determined. An estimated fetal weight (EFW) at or below the 10th percentile was defined as SGA. Microphone recordings from the lower abdomen were divided into heart valve sounds and MVMs.ResultsThe final analysis included 63 participants, with 25 classified as SGA and 38 as non‐SGA. The mean pregnancy duration was 32.4 ± 1.4 weeks. In total, 17 participants had MVMs. There was a clear association between MVMs and a composite of SGA and an abnormal PI of the uterine and/or the umbilical artery (P<0.001), but not between MVMs and SGA only (P=0.154).ConclusionMaternal vascular murmurs are significantly associated with fetal growth restriction, but not with SGA per se.
Multilingual Literacies: Invisible Representation of Literacy in a Rural Classroom
Authors: Kiramba Lydiah Kananu 
Published: July 2017

AbstractIn many countries, educational policies typically mandate school activities that promote a homogeneous and narrow range of academic literacies for all learners despite the diverse nature of human learning. This ethnographic case study examines how a 12‐year‐old Kenyan fourth‐grade student performing below average on all standardized tests used multiple invisible literacies while documenting his knowledge and life experiences in a rural context. Invisible literacies are covert meaning‐making literacy practices that are not privileged in the classroom. Examination of these practices shows a convergence between school and home literacies, suggesting a need for education stakeholders to identify literacies that are otherwise marginalized and to reposition multilingual learners in nondeficit ways by centering and integrating these literacies. This study demonstrates that a monolithic and monolingual approach to literacy, in isolation from other visual, oral, and practical forms of literacy used by multilingual rural students, denies such learners access to and development of literacy in general.
Diagnosis of chronic heart failure by the soluble suppression of tumorigenicity 2 and N‐terminal pro‐brain natriuretic peptide
Authors: Jin Xiao‐Ling , Huang Ning , Shang Hui , Zhou Ming‐Cheng , Hong Yi , Cai Wen‐Zheng , Huang Jie 
Published: July 2017

ObjectiveOur study was to explore the roles between serum soluble suppression of tumorigenicity 2 (sST2) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) while evaluating ventricular function to properly diagnose chronic heart failure (CHF).MethodsIn total, 197 CHF patients were recruited and classified into ventricular function's II, III, and IV groups, and 106 healthy people into normal control group. To detect concentrations of Sst2 and NT‐proBNP, ELISA and electro‐chemiluminescence immuno assay were implemented. An automatic biochemical analyzer was used to determine the levels of the following: blood urea nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and uric acid (UA). A receiver operating characteristic (ROC) curve was adopted to detect the diagnostic value sST2 and NT‐ProBNP in CHF and the logistic regression analysis involving the risk factors of CHF.ResultsSerum sST2 and NT‐proBNP concentrations were increased significantly in the ventricular function's II, III, and IV groups in a manner dependent on concentration as opposed to the manner the normal control group occupied. The area under the curve (AUC) of sST2, found NT‐proBNP and sST2+NT‐proBNP to be 0.942 (95% CI: 0.917‐0.966), 0.920 (95% CI: 0.891‐0.948), and 0.968 (95% CI: 0.953‐0.984), respectively. sST2, NT‐proBNP, UA, and Cr were verified as important risk factors of CHF.ConclusionSerum sST2 and NT‐ProBNP could act as diagnostic indicators for CHF.
Multimodal analgesia as an alternative to the risks of opioid monotherapy in surgical pain management
Authors: Savarese John J. , Tabler Norman G. 
Published: July 2017

Clinicians have long been aware of the danger of overreliance on opioids to manage acute pain, such as the pain accompanying surgery. The risk of adverse drug events is higher with opioids than with any other common class of drugs. Overreliance on opioids increases length of stay and hospital costs, while decreasing patient satisfaction. Opioids can lead to problems that continue well after discharge, including chronic pain, abuse and addiction, and even death. Increasingly, prescribed opioids have proved to lead to heroin addiction. Studies show that the same professionals who prescribe, administer, and monitor opioids lack basic knowledge about their safe and effective use.The alternative to opioid monotherapy in controlling acute pain is multimodal analgesia, an approach that relies on a nonopioid foundation with addition of adjunctive opioids as needed. An increasing number of nonopioid analgesics have proved effective in this role, with fewer side effects and a higher degree of safety than opioids. Accordingly, multimodal analgesia is recommended as best practice by most recognized authorities.Increasingly, governmental authorities hold prescribing clinicians and institutions legally liable for the downstream negative effects of opioids, including abuse and addiction. Addressing this issue should be a top priority for hospital risk managers.
A novel cell‐cell communication mechanism in the nervous system: exosomes
Authors: Zhang Guan , Yang Ping 
Published: July 2017

AbstractExosomes are small extracellular membrane‐based vesicles with a variety of cargoes that are involved in numerous physiological and pathological processes in the nervous system. Accumulating evidence has implicated that exosomes are emerging as a novel form of intercellular communication within the nervous system. In this review, we first illustrate exosome metabolism including its formation, secretion, transport, and uptake. Second, we compare exosomes to synaptic vesicles in terms of intercellular messengers and communicators. Third, we discuss the roles and prospects of exosomes in the diagnosis and treatment of neurodegenerative diseases.
Maturation‐related changes of carrot lignins
Authors: Schäfer Judith , Trierweiler Bernhard , Bunzel Mirko 
Published: July 2017

AbstractBACKGROUNDLignified cell walls are important factors for textural and physiological properties of plant‐based foods. However, carrot lignins and their modifications during maturation are poorly described. The objective of this study was to describe carrot lignins in detail and to study lignin structural alterations at later stages of maturity.RESULTSKlason and acetyl bromide soluble lignin contents of insoluble fibers of carrots harvested at different times (26, 29 and 35 weeks after seeding) ranged between 46.38 and 62.68 g kg−1 and between 19.79 and 28.08 g kg−1, respectively. As determined by both 2D‐nuclear magnetic resonance and the derivatization followed by reductive cleavage method, coniferyl alcohol heavily dominated the traditional monolignol composition in carrot lignins, independently of harvest times. By using 2D‐nuclear magnetic resonance experiments on isolated lignins, p‐hydroxybenzoate was identified as a less common lignin constituent, attached to lignin γ‐hydroxyl groups and being increasingly incorporated with maturation. β‐Aryl ethers, phenylcoumaran, resinol and dibenzodioxocin structures were identified as lignin interunit linkages, largely independent of harvest times and with β‐aryl ethers being expectedly dominant.CONCLUSIONCarrots contain guaiacyl‐rich lignins that incorporate increasing amounts of p‐hydroxybenzoate with maturation. All other lignin characteristics appear to be widely independent of harvest times. © 2017 Society of Chemical Industry
Microcapsules biologically prepared using Perilla frutescens (L.) Britt. essential oil and their use for extension of fruit shelf life
Authors: Li Na , Zhang Zhi‐Jun , Li Xiao‐Jun , Li Hui‐Zhen , Cui Li‐Xia , He Dong‐Liang 
Published: July 2017

AbstractBACKGROUNDPerilla essential oil (EO) possesses high antioxidant, antimicrobial and insecticidal activities, and has proven to be more reliable than chemically synthesized food preservatives. Nevertheless, EOs have disadvantages of facile photo‐degradation and oxidation, which limit their use in agriculture and food industries. Microencapsulation technology that generates a polymeric coating surrounding EOs could overcome these disadvantages.RESULTSThe EO concentration had a significant effect on encapsulation efficiency (EE) and loading capacity (LC). The best encapsulation conditions were obtained with 2% v/v EO, for which EE and LC were 57% and 36%, respectively. EO‐loaded microspheres exhibited a crimped surface with phanic lumps by scanning electron microscopy. Thermal stability experiments revealed droplets that began to decompose sharply at 108 °C, with a 61% weight, loss, which was much lower than EOs of 98%. EO‐loaded microcapsules demonstrated good antibacterial activity. Strawberry preservation studies showed that EO‐loaded microcapsules could significantly inhibit strawberry decay, maintain the quality of strawberries and prolong shelf life.CONCLUSIONPerilla EO‐loaded microcapsules were successfully prepared by ionic gelation and were effective at inhibiting several bacterial strains. EO–alginate microcapsules could effectively delay the volatilization of EO. Perilla EO‐loaded microcapsules therefore have potential for use as an antimicrobial and preservative agent in the food industry. © 2017 Society of Chemical Industry