bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic urinary bladder hyperactivity by reducing TRPV1 and P2X3
Authors: Li Guang-Yong , Ren Shuai , Huang Bin-Cheng , Feng Jia-Jin , Wang Qiang-Qiang , Peng Qing-Jie , Tian Hai-Fu , Yu Le-Yi , Ma Cun-Ling , Fan Shu-Zhe , Chen Xiao-Jiang , Al-Qaisi Mohammed Abdulkarem , He Rui 
Published: February 2025

BACKGROUND
Diabetes mellitus (DM) is linked to an earlier onset and heightened severity of urinary complications, particularly bladder dysfunction, which profoundly impacts patient quality of life. Overactive bladder (OAB) is a common storage disorder of the lower urinary tract and is characterized by urgency, frequency, and nocturia. Several factors contribute to bladder dysfunction in diabetic individuals, including changes in urothelial signaling, detrusor morphology, and central nervous system regulation. The transient receptor potential vanilloid type 1 channel, expressed by bladder urothelial cells, is upregulated in OAB and plays a crucial role in ATP release during bladder filling. This ATP release subsequently activates purinergic receptor P2X3, further exacerbating OAB symptoms.
AIM
To clarify the mechanism of Roux-en-Y gastric bypass (RYGB) metabolic surgery to improve OAB in type 2 DM (T2DM).
METHODS
The model of T2DM was induced by feeding a high-fat diet to mice for 16 weeks. After 16 weeks, sham operation and RYGB operation were performed. The related indexes of glucose metabolism were also detected to evaluate the therapeutic effect, and the recovery degree of bladder function and micturition behavior of mice was assessed by urodynamics and micturition spot analysis.
RESULTS
Compared with the normal mice in the sham group, T2DM mice had increased urine spot count, uncontrolled urination behavior, shortened urination interval, and reduced bladder capacity. Immunohistochemistry and immunofluorescence costaining showed that Transient receptor potential vanilloid type 1 (TRPV1) and purinergic receptor P2X3 were both expressed in mouse bladder epithelial layer, and they had the same localization. In the bladder of T2DM mice, the mRNA and protein expression of TRPV1 and P2X3 were significantly increased. The ATP content in urine of T2DM mice was significantly higher than that of the sham group. After RYGB operation, the glucose metabolism index of the RYGB group was significantly improved compared with the OAB group. Comparing the results of urine spots, urodynamics, and histology, it was found that the function and morphological structure of the bladder in the RYGB group also recovered obviously. Compared with the OAB group, the expression of TRPV1 and P2X3 in the RYGB group was downregulated, and the level of inflammatory factors was significantly decreased. RYGB significantly decreased the content of ATP in urine and activated AMPK signaling.
CONCLUSION
RYGB downregulated the expression of TRPV1 by inhibiting inflammatory factors, thus inhibiting the enhancement of P2X3 by TRPV1. RYGB directly inhibited the activity of P2X3 by inhibiting ATP synthesis in the bladder epithelium to improve OAB.
Could vitamin supplementation unlock the hidden potential of the indigenous Gerze chicken?
Authors: Cilavdaroglu E. , Yamak U.S. 
Published: February 2025

In this study, the broiler performance of Turkish Gerze chickens was investigated. One hundred and thirty day-old chicks were reared under intensive conditions until 20 weeks of age to examine whether administering a vitamin supplement via their drinking water would affect broiler performance. During this period, one group received the vitamin supplement, starting at four weeks of age, and the other (the control group) did not. At 20 weeks old, the chickens given the vitamin supplement had an average live weight of 1686 g and a feed conversion ratio of 4.47, while the control group was significantly lighter, at 1408 g, with a feed conversion ratio of 4.63. Dressing percentages were not significantly affected by vitamin supplementation, and averaged around 68%. The proportion of edible giblets also did not significantly differ between the two groups, contributing approximately 5%–6% of the carcass. The largest carcass component in both treatment groups was the legs, constituting 32%–33% of the carcass in males and 28% in females. Breast meat made up 22%–27% of the carcass, and this was not significantly influenced by vitamin supplementation. The pH and colour of the breast and leg meat were evaluated as meat quality traits, and these quality parameters were within acceptable limits for poultry meat for all groups.
The Satisfaction Degree of Parents and Teachers toward Lower Basic Stage Students' Through Distance Learning and Obstacles They Faced and their Suggestions of Solution
Authors: Aljarrah Abdelmuhdi Ali 
Published: February 2025

The current study aimed to investigate the degree of satisfaction toward distance Learning for Parents and teachers of the primary school’s students in Jordan during the period of Corona pandemic, in addition to investigate the obstacles degree that faced them and their suggestions to solve those obstacles. To achieve the objectives of the study, the descriptive survey methodology was used, whereby a questionnaire was developed as a tool for data collection, as its validity and reliability were confirmed. The study sample consisted of (185) parents and (57) teachers. The results of the study showed that the means and standard deviations related to the degree of parents and teacher’s satisfaction towards distance learning ranged from low to medium, and for the obstacles degree they faced during the use of distance learning in light of the Corona pandemic was medium to high, in addition to that some suggestion from parents and teachers where obtained.
The Degree of Secondary School Principals Practicing their Role in Activating the Community Partnership to Confront the Corona Pandemic within the Greenline
Authors: Assi Yathreb K. , Olimat Saleh Naser 
Published: February 2025

This study aimed at investigating the degree of secondary school principals practicing their role in activating the community partnership to confront the Corona pandemic within the Greenline from school administrators and nurses’ point of view. The study sample consisted of (224) Administrators and Nurses. The descriptive survey methodology was used, the study questionnaire consisted of (30) items, its validity and reliability were confirmed. The study results showed that the degree of secondary school principals practicing their role in activating the community partnership to confronting the Corona pandemic within the Greenline came with large degree, and there was no statistically significant differences in all study questionnaire dimensions and as a whole due to gender, years of experience.
Inovasi Pembelajaraan Ilmu Pengetahuan Sosial untuk Membangun Karakter dan Keterampilan Abad-21 di Sekolah
Authors: Syapurrohman Purnama , Nastiah Najwa Alya , Rahmawati Lulu , Ruslan Ahmad 
Published: February 2025

Social studies learning is a science that considers various social studies disciplines and basic human activities and combines them naturally so as to provide deep insight and understanding to students. Social studies learning in schools currently aims to improve the quality of education and enable social studies to truly gain understanding, critical thinking and problem solving skills in everyday life. Teachers must be able to adapt their learning methods to current developments. Nowadays, not only teachers convey information, but students also participate in the learning process. In the 21st century, information technology continues to develop. Development is increasingly advanced and rapid. The aim of this literature study is to: 1) Find out whether social studies learning at school is related to the skills needed in the 21st century. 2) Identify what skills can be obtained through social studies learning at school. 3) Explain how to learn and apply the development of 21st century skills in social studies learning. The articles analyzed are the results of empirical and conceptual studies. The research results show that the 2006 Curriculum, the 2013 Curriculum, and the Merdeka Curriculum utilize K21 differently in social studies learning. The findings show that studying the social sciences is still relevant for skills development in the 21st century. Skills gained through the study of social sciences include interpersonal skills, collaboration skills, networking skills, and communication skills. In order to effectively incorporate 21st century skills into social studies learning, the learning model needs innovation.
Sustainable Development Goals and Energy Efficiency in Educational Institutions Through Smart Buildings and Machine Learning
Authors: Tabaku Eda , Vyshka Eli , Kapçiu Rinela 
Published: February 2025

Objective: This study aims to identify key characteristics of smart buildings that enhance sustainability and energy efficiency in educational institutions. By leveraging artificial intelligence, particularly machine learning, the study seeks to optimize energy consumption and improve learning environments.

Theoretical Framework: Smart buildings integrate digital and communication technologies to enhance educational infrastructure. Despite their benefits, adoption in developing countries remains limited. This study builds on theories of sustainable energy management and computational optimization, emphasizing machine learning’s role in predictive energy modeling.

Method: A machine learning model was developed to predict energy consumption in educational institutions. The k-nearest neighbor (k-NN) algorithm was applied using open-access data from the University of Durrës Building Energy Management System. Model validation was conducted through comparative analysis, assessing prediction accuracy and energy-saving potential.

Results and Discussion: The model achieved an average relative error of 18.26%, confirming its predictive capability. Smart features enabled energy savings between 44.8% and 58.3%, depending on analyzed spaces. Additionally, an AI-powered interactive dashboard was proposed for real-time energy monitoring and optimization, aiding facility managers.

Research Implications: This study underscores the role of smart buildings in promoting sustainability and reducing operational costs. AI-driven energy management systems can significantly enhance institutional sustainability practices.

Originality/Value: This research demonstrates the effectiveness of machine learning in energy consumption prediction and proposes an AI-based solution for sustainable energy management in educational buildings. The findings provide valuable insights into integrating smart technologies for sustainability and efficiency.
Women in Leadership Roles: A Case Study of Gender Diversity in Saudi Corporate Management
Authors: Alsalman Asmahan Ibrahim 
Published: February 2025

Objectives: This study investigates the representation and experiences of women in leadership roles within Saudi Arabian corporate management, with a focus on gender diversity. It aims to assess the progress of gender diversity initiatives, identify challenges faced by women in leadership, and explore the cultural and organizational barriers that influence their career advancement. The research seeks to provide a comprehensive understanding of the factors shaping women's leadership experiences in Saudi corporate settings.

Methods: The study employs a mixed-methods approach, combining both quantitative and qualitative research. The quantitative component involved surveying a diverse sample of 250 corporate employees to assess perceptions of gender diversity, challenges, and progress in leadership representation. Simultaneously, qualitative insights were gathered through in-depth interviews with 70 women in leadership positions. These interviews explored their personal experiences, career trajectories, and the structural and cultural obstacles they encounter in corporate management.

Results: The findings reveal a complex landscape of both progress and persistent challenges. While there have been improvements in gender diversity in corporate leadership over recent years, women continue to face significant barriers in achieving higher leadership positions. Cultural norms, organizational biases, and structural limitations remain key obstacles. However, personal narratives from female leaders highlight resilience, adaptive strategies, and gradual shifts in corporate policies that are fostering greater inclusion.

Conclusion: This study contributes to the broader discourse on gender diversity in leadership by providing empirical evidence and personal accounts of women’s experiences in Saudi corporate management. It underscores the intricate interplay of cultural, organizational, and individual factors shaping women’s leadership opportunities. The research offers policy and practice recommendations aimed at creating a more inclusive and equitable corporate environment, ultimately supporting greater gender representation in leadership roles.
Comparative Analysis of Laws in AI
Authors: Basu Nibedita , Dave Rhishikesh 
Published: February 2025

Objectives: This article aims to examine the global efforts in regulating artificial intelligence (AI), highlighting the diverse approaches taken by different countries. It focuses on key regulatory parameters such as ethical concerns, privacy, security, and economic impact. Additionally, the study explores the legislative gap in India, where policy frameworks exist but no specific AI law has been enacted.

Methods: The research adopts a qualitative approach, utilizing comparative analysis to assess AI regulations across various countries. The study evaluates how the European Union, the United States, China, and India implement AI governance, with a particular focus on India's regulatory landscape and the need for a vigilant approach in an emerging economy.

Results: The findings reveal that while the EU has implemented comprehensive AI regulations, other nations, including the US, China, and India, rely on sector-specific and strategic frameworks. Most regulations primarily address commercial and human rights concerns. In India, although policy frameworks exist, the absence of a dedicated AI law creates a legislative gap, raising concerns about market disruptions and ethical oversight.

Conclusion: Regulating AI remains a global challenge, with different nations adopting varied approaches. For an emerging economy like India, balancing innovation with regulation is crucial to prevent market disruption. The study suggests that a well-structured AI regulatory framework is necessary to ensure ethical AI deployment while fostering economic growth and technological advancement.
TINJAUAN KELENGKAPAN PENULISAN DIAGNOSIS DAN KETEPATAN KODE DIAGNOSIS PASIEN RAWAT JALAN OBGYN DI RUMAH SAKIT UMUM AISYIYAH PADANG TAHUN 2024
Authors: Rahmadhani Rahmadhani , Dewi Siti Handam , Mardiawati Dewi , Putra Heru Rahmat Wibawa , Azizah Putri Aulia 
Published: February 2025

ABSTRAK
Ketepatan diagnosis utama yang ditetapkan pada akhir episode pengobatan pasien mempengaruhi kualitas berkas rekam medis dan dinilai dari kesesuaian diagnosis dengan ICD-10. Tujuan dalam penelitian ini adalah untuk diketahuinya bagaimana tinjauan ketepatan kode diagnosis dan kelengkapan penulisan diagnosis pasien rawat jalan obgyn di RSU Aisyiyah Padang tahun 2024. Penelitian kuantitatif deskriptif ini dilakukan di RSU Aisyiyah Padang dari 01 hingga 06 Mei 2024, dengan populasi 303 lembar SBPK dan sampel 75 lembar SBPK. Teknik pengumpulan sampel yang digunakan adalah accidental sampling. Pengumpulan data menggunakan teknik observasi dengan instrumen tabel checklist dan pengolahan data menggunakan teknik editing, coding, processing, dan cleaning. Data yang didapatkan dianalisis menggunakan analisa univariat. Hasil penelitian menunjukkan kelengkapan penulisan diagnosis sebanyak (33.3%) dari 25 lembar SBPK yang tidak lengkap dan sebanyak (66.7%) dari 50 lembar SBPK yang lengkap dan ketepatan kode diagnosis sebanyak (36.0%) dari 27 lembar SBPK yang tidak tepat dan sebanyak (64.0%) dari 48 lembar SBPK yang tepat. Berdasarkan hasil penelitian disimpulkan bahwa masih banyak terdapat ketidaklengkapan penulisan diagnosis dan ketidaktepatan kode diagnosis. Diharapkan dokter menuliskan diagnosis penyakit dengan lengkap dan tepat sesuai kaidah dan aturan yang ada dalam ICD-10.
Optimization of Medium Components for Enhancing Antibacterial Activity of Marine Streptomyces aureofaciens A3 through Response Surface Methodology
Authors: Srikandace Yoice , Kamarisima Kamarisima , Putri Sastia Prama , Adiatiawati Pingkan 
Published: February 2025

This study is the first to report on the statistical optimization of an antibacterial production medium for the marine bacterium Streptomyces aureofaciens A3. Glycolic and furoic acids have not been previously documented as metabolites produced by Streptomyces, especially by S. aureofaciens A3. The antibacterial metabolites were generated in an ISP4 medium enriched with artificial seawater with different concentrations of starch, NaCl, and ammonium sulfate. Media components were optimized through the Response Surface Method (RSM) using the Box-Behnken design (BBD) in submerged fermentation. Antibacterial metabolites produced during fermentation were extracted with ethyl acetate (EA) to obtain EA extracts. The extract activities were tested using the Kirby-Bauer method, and the extract compounds were annotated using GC/MS. The results showed that the specific concentrations of starch, ammonium sulfate, and NaCl enhanced the antibacterial activity for each tested bacteria were 11.06 - 12.07 g/L for starch and 1.39 - 1.56 g/L for ammonium sulfate and 1.76 - 2.45 g/L for NaCl. The media increased higher antibacterial activity against pathogens with rising percentages of inhibition zones of E. coli (62.33 %), S. aureus (9.41 %), S. typhimurium (48.69 %), P. aeruginosa (39.16 %) and B. subtilis (8.58 %), respectively. The inhibition zones of each test bacteria were 10.88 - 17.97 mm and categorized as strong antibacterial activity. GC/MS derivatization results showed that the annotated compounds in EA extracts consisted of primary metabolites such as glycolic acid, palmitic acid, stearic acid, lauric acid, myristic acid, oleic acid and secondary metabolites were furoic acid, phthalate acid, benzoic acid, methylmalonic acid. This study showed that the RSM method is efficient and effective for improving the activity of broad-spectrum antibacterial agents produced by S. aureofaciens A3. The application of RSM to optimize ISP4 medium enables the large-scale production of antibacterial metabolites for the pharmaceutical industry.
HIGHLIGHTS

The antibacterial activity of marine Streptomyces aureofaciens A3 was first optimized using the Response Surface Method with ISP4-modified media.
Broad-spectrum antibacterial activity increases against all pathogenic bacteria with a media composition similar to seawater.
The low ammonium sulfate concentration induces higher antibacterial activity against bacterial pathogens.

GRAPHICAL ABSTRACT
Comparison of P-Possum and Esas (Emergency Surgery Acuity Score) For Prediction of 30-Day Mortality in Patients Undergoing Emergency Laparotomy
Authors: Ibn E Ali Paras , Ilyas Sohail , Ashraf Sohaib , Zafar Hamayal , Kazmi Farwa , Siddiqui Ubaid Ullah 
Published: February 2025

Objective: To evaluate the validity of the Portsmouth Physiological and Operative Severity Score for the enumeration of Mortality and morbidity (P-POSSUM) and Emergency Surgery Acuity Score (ESAS) scoring system and compare the positive predictive value of both in predicting 30 days’ mortality in patients undergoing emergency laparotomy.
Study Design: Prospective longitudinal study.
Place and Duration of Study: Department of Surgery and Department of Accident and Emergency, Combined Military Hospital Rawalpindi, Pakistan from Aug 2021 to Mar 2022.
Patients and methods: A total of 210 patients were enrolled in the study, with 30-day post-operative mortality as the primary outcome of interest. P-POSSUM and ESAS scores were calculated for all patients upon presentation to the surgical emergency. A cutoff of 19 for ESAS and 63 for P-POSSUM was used to predict 30-day post-operative mortality in emergency laparotomy patients.
Results: The observed mortality rate among the recruited patients was 9.5%. The mean age was 46.24±11.13 years, with 62.4% of the population being male. Among those who died within 30 days of follow-up, the majority were aged over 50 years (p=0.002) and predominantly male (p=0.460), with most having ileal or jejunal perforation. The AUROC for ESAS in predicting 30-day post-operative mortality was 0.974, while for P-POSSUM it was 0.885.
Conclusion: ESAS and P-POSSUM can both be employed in emergency surgical situations. As ESAS can be calculated pre-operatively, it should be preferred over P-POSSUM.
An updated non-intrusive, multi-scale, and flexible coupling interface in WRF 4.6.0
Authors: Masson Sébastien , Jullien Swen , Maisonnave Eric , Gill David , Samson Guillaume , Le Corre Mathieu , Renault Lionel 
Published: February 2025

Abstract. The Weather Research and Forecasting (WRF) model has been widely used for various applications, especially for solving mesoscale atmospheric dynamics. Its high-order numerical schemes and nesting capability enable high spatial resolution. However, a growing number of applications are demanding more realistic simulations through the incorporation of coupling with new model compartments and an increase in the complexity of the processes considered in the model (e.g., ocean, surface gravity wave, land surface, and chemistry). The present paper details the development and the functionalities of the coupling interface we implemented in WRF. It uses the Ocean–Atmosphere–Sea–Ice–Soil Model Coupling Toolkit (OASIS3-MCT) coupler, which has the advantage of being non-intrusive, efficient, and very flexible to use. OASIS3-MCT has already been implemented in many climate and regional models. This coupling interface is designed with the following baselines: (1) it is structured with a two-level design through two modules: a general coupling module and a coupler-specific module, allowing for easy additions of other couplers if required; (2) variable exchange, coupling frequency, and any potential time and grid transformations are controlled through an external text file, offering great flexibility; and (3) the concepts of external domains and a coupling mask are introduced to facilitate the exchange of fields to/from multiple sources (different models, fields from different models/grids/zooms, etc.). Finally, two examples of applications of ocean–atmosphere coupling are proposed. The first is related to the impact of ocean surface current feedback to the atmospheric boundary layer, and the second concerns the coupling of surface gravity waves with the atmospheric surface layer.