bluuebunny/crossref_metadata_2025_split huggingface dataset:
Filling the void—enriching the feature space of successful stopping
Authors: Huster René J. , Schneider Signe , Lavallee Christina F. , Enriquez‐Geppert Stefanie , Herrmann Christoph S. 
Published: November 2016

AbstractThe ability to inhibit behavior is crucial for adaptation in a fast changing environment and is commonly studied with the stop signal task. Current EEG research mainly focuses on the N200 and P300 ERPs and corresponding activity in the theta and delta frequency range, thereby leaving us with a limited understanding of the mechanisms of response inhibition. Here, 15 functional networks were estimated from time–frequency transformed EEG recorded during processing of a visual stop signal task. Cortical sources underlying these functional networks were reconstructed, and a total of 45 features, each representing spectrally and temporally coherent activity, were extracted to train a classifier to differentiate between go and stop trials. A classification accuracy of 85.55% for go and 83.85% for stop trials was achieved. Features capturing fronto‐central delta‐ and theta activity, parieto‐occipital alpha, fronto‐central as well as right frontal beta activity were highly discriminating between trial‐types. However, only a single network, comprising a feature defined by oscillatory activity below 12 Hz, was associated with a generator in the opercular region of the right inferior frontal cortex and showed the expected associations with behavioral inhibition performance. This study pioneers by providing a detailed ranking of neural features regarding their information content for stop and go differentiation at the single‐trial level, and may further be the first to identify a scalp EEG marker of the inhibitory control network. This analysis allows for the characterization of the temporal dynamics of response inhibition by matching electrophysiological phenomena to cortical generators and behavioral inhibition performance. Hum Brain Mapp 38:1333–1346, 2017. © 2016 Wiley Periodicals, Inc.
Transcranial direct current stimulation effects on neural processing in post‐stroke aphasia
Authors: Darkow Robert , Martin Andrew , Würtz Anna , Flöel Agnes , Meinzer Marcus 
Published: November 2016

AbstractNon‐invasive transcranial direct current stimulation (tDCS) can enhance recovery after stroke. However, fundamental knowledge about how tDCS impacts neural processing in the lesioned human brain is currently lacking. In the present study, it was investigated how tDCS modulates brain function in patients with post‐stroke language impairment (aphasia). In a cross‐over, randomized trial, patients named pictures of common objects during functional magnetic resonance imaging (fMRI). Concurrently, excitatory (anodal‐) or sham‐tDCS (1 mA, 20 min, or 30 s, respectively) was administered to the left primary motor cortex, a montage with demonstrated potential to improve aphasic language. By choosing stimuli that could reliable be named by the patients, the authors aimed to derive a pure measure of stimulation effects that was independent of treatment or performance effects and to assess how tDCS interacts with the patients' residual language network. Univariate fMRI data analysis revealed reduced activity in domain‐general regions mediating high‐level cognitive control during anodal‐tDCS. Independent component functional network analysis demonstrated selectively increased language network activity and an inter‐correlated shift from higher to lower frequency bands, indicative of increased within‐network communication. Compared with healthy controls, anodal‐tDCS resulted in overall “normalization” of brain function in the patients. These results demonstrate for the first time how tDCS modulates neural processing in stroke patients. Such information is crucial to assure that behavioral treatments targeting specific neural circuits overlap with regions that are modulated by tDCS, thereby maximizing stimulation effects during therapy. Hum Brain Mapp 38:1518–1531, 2017. © 2016 Wiley Periodicals, Inc.
Investigation of submarine groundwater discharge to tidal rivers: Evidence for regional and local scale seepage
Authors: Tamborski Joseph J. , Rogers A. Deanne , Bokuniewicz Henry J. 
Published: November 2016

AbstractFluxes of submarine groundwater discharge (SGD) were investigated into two tidal rivers on the north and south shore of Long Island, NY, during July 2015. Ground‐based handheld thermal infrared (TIR) imagery, combined with direct push‐point piezometer sampling, documented spatially heterogeneous small‐scale intertidal seepage zones. Pore waters were relatively fresh and enriched in nitrogen (N) within these small‐scale seeps. Pore waters sampled just 20 cm away, outside the boundary of the ground‐based TIR‐located seepage zone, were more saline and lower in N. These ground‐based TIR‐identified seeps geochemically represented the terrestrial fresh groundwater endmember, whereas N in pore waters sampled outside of the TIR‐identified seeps was derived from the remineralization of organic matter introduced into the sediment by tidal seawater infiltration. A 222Rn (radon‐222) time‐series was used to quantify fresh SGD‐associated N fluxes using the N endmembers sampled from the ground‐based TIR pore water profiles. N fluxes were up‐scaled to groundwater seepage zones identified from high‐resolution airborne TIR imagery using the two‐dimensional size of the airborne TIR surface water anomalies, relative to the N flux from the time‐series sampling location. Results suggest that the N load from the north‐shore tidal river to Long Island Sound is underrepresented by at least 1.6–3.6%, whereas the N load from SGD to a south‐shore tidal river may be up to 9% higher than previous estimates. These results demonstrate the importance of SGD in supplying nutrients to the lower reaches of tidal rivers and suggest that N loads in other tidal river environments may be underestimated if SGD is not accounted for.
Quantifying the growth ofchlamydia suisin cell culture using high‐content microscopy
Authors: De Puysseleyr Leentje , De Puysseleyr Kristien , Vanrompay Daisy , De Vos Winnok H. 
Published: November 2016

AbstractThe porcine pathogenChlamydia suisis widespread in pig farming. Isolation ofChlamydia suisin cell culture is crucial for the generation and characterization of new isolates. However, isolation ofChlamydia suisstrains from field samples is fastidious. Therefore, we exploited high‐content microscopy to quantify the growth ofChlamydia suisstrains in different cell lines. We found that the cell line yielding optimal propagation of Chlamydia suis differed among isolates, and we identified cell lines outperforming those routinely used for chlamydial isolation. We conclude that adaptation of the propagation procedure to the origin of the putative field isolate is highly recommended to improve the recovery rate.
Impact of pancreatectomy on long‐term patient‐reported symptoms and quality of life in recurrence‐free survivors of pancreatic and periampullary neoplasms
Authors: Cloyd Jordan M. , Tran Cao Hop S. , Petzel Maria Q.B. , Denbo Jason W. , Parker Nathan H. , Nogueras‐González Graciela M. , Liles Joseph S. , Kim Michael P. , Lee Jeffrey E. , Vauthey Jean‐Nicolas , Aloia Thomas A. , Fleming Jason B. , Katz Matthew H.G. 
Published: November 2016

BackgroundLong term patient‐reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy.MethodsWe conducted a cross‐sectional survey of recurrence‐free survivors of pancreatic ductal adenocarcinoma, periampullary carcinomas, and pancreatic neuroendocrine tumors who had undergone prior pancreatectomy. QOL and symptom burden were measured using the Functional Assessment of Cancer Therapy–Hepatobiliary Questionnaire, and psychosocial distress was measured using the Hospital Anxiety and Depression Scale.ResultsOf 331 eligible patients surveyed, 217 (66%) participated at a median of 53.3 (range, 7.6–214.8) months following pancreatoduodenectomy (PD, n = 165) or distal pancreatectomy (DP, n = 52). Among all patients, overall QOL scores were favorable and influenced by race, histology, and type of surgery. The most common significant symptoms reported were fatigue (82%), back pain (32%), and difficulty with digestion (31%). In general, PD survivors reported better QOL, lower levels of anxiety/depression, greater levels of diarrhea, and improved appetite, constipation, fatigue, anxiety, and depression (P < 0.05) than DP survivors. On both univariate and multivariate regression analysis, DP was negatively associated with QOL.ConclusionsMost disease‐free survivors of pancreatic neoplasms report favorable QOL, but gastrointestinal and psychosocial symptoms may exist long after pancreatectomy. J. Surg. Oncol. 2017;115:144–150. © 2016 Wiley Periodicals, Inc.
Diffusion (DOSY) 1H NMR as an Alternative Method for Molecular Weight Determination of Poly(ethylene furanoate) (PEF) Polyesters
Authors: Rosenboom Jan‐Georg , De Roo Jonathan , Storti Giuseppe , Morbidelli Massimo 
Published: November 2016

Poly(ethylene furanoate) (PEF) is a promising 100% biomass‐derived alternative to poly(ethylene terephthalate) (PET), but challenges all solution characterization methods due to its insolubility in most common solvents. Diffusion (DOSY) 1H NMR can be an alternative, reliable and fast method to analyze molecular weights of PEF polyesters. Calibration with PET standards yields excellent agreement of DOSY predictions with the absolute Mn and Mw values obtained via size exclusion chromatography equipped with multi‐angle light scattering detector in the range of commercial relevance (Mw < 100 000 g mol−1). Mean square displacement analysis shows unhindered molecular diffusion for all tested concentrations (from 0.4 to 30 mg mL−1). The DOSY procedure can be optimized toward shorter analysis times (down to 1 min) and a more straightforward implementation, making it a powerful and fast tool for molecular weight analysis in the laboratory as well as in industrial process applications.
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CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis
Authors: Leung Gordon K. C. , Ying Dingge , Mak Christopher C. Y. , Chen Xin‐Ying , Xu Weiyi , Yeung Kit‐San , Wong Wai‐Lap , Chu Yoyo W. Y. , Mok Gary T. K. , Chau Christy S. K. , McLuskey Jenna , Ong Winnie P. T. , Leong Huey‐Yin , Chan Kelvin Y. K. , Yang Wanling , Chen Jeng‐Haur , Li Albert M. , Sham Pak C. , Lau Yu‐Lung , Chung Brian H. Y. , Lee So‐Lun 
Published: November 2016

AbstractBackgroundCystic fibrosis (CF) is a rare condition in Asians. Since 1985, only about 30 Chinese patients have been reported with molecular confirmation.MethodUsing our in‐house next‐generation sequencing (NGS) pipeline for childhood bronchiectasis, we identified disease‐causing CFTR mutations in CF patients in Hong Kong. After identifying p.I1023R in multiple patients, haplotype analysis was performed with genome‐wide microarray to ascertain the likelihood of this being a founder mutation. We also assessed the processing and gating activity of the mutant protein by Western hybridization and patch‐clamp test.ResultsMolecular diagnoses were confirmed in four patients, three of whom shared a missense mutation: CFTR:c.3068T>G:p.I1023R. The results suggested that p.I1023R is a founder mutation in southern Han Chinese. In addition, the processing and gating activity of the mutant protein was assessed by gel electrophoresis and a patch‐clamp test. The mutant protein exhibited trafficking defects, suggesting that the dysfunction is caused by reduced cell surface expression of the fully glycosylated proteins.ConclusionTogether with other previously reported mutations, the specific founder mutation presented herein suggests a unique CFTR mutation spectrum in the southern Chinese populations, and this finding has vital implications for improving molecular testing and mutation‐specific treatments for Chinese patients with CF.
Classifying child and adolescent psychiatric disorder by problem checklists and standardized interviews
Authors: Boyle Michael H. , Duncan Laura , Georgiades Kathy , Bennett Kathryn , Gonzalez Andrea , Van Lieshout Ryan J. , Szatmari Peter , MacMillan Harriet L. , Kata Anna , Ferro Mark A. , Lipman Ellen L. , Janus Magdalena 
Published: November 2016

AbstractThis paper discusses the need for research on the psychometric adequacy of self‐completed problem checklists to classify child and adolescent psychiatric disorder based on proxy assessments by parents and self‐assessments by adolescents. We put forward six theoretical arguments for expecting checklists to achieve comparable levels of reliability and validity with standardized diagnostic interviews for identifying child psychiatric disorder in epidemiological studies and clinical research. Empirically, the modest levels of test–retest reliability exhibited by standardized diagnostic interviews – 0.40 to 0.60 based on kappa – should be achievable by checklists when thresholds or cut‐points are applied to scale scores to identify a child with disorder. The few studies to conduct head‐to‐head comparisons of checklists and interviews in the 1990s concurred that no construct validity differences existed between checklist and interview classifications of disorder, even though the classifications of youth with psychiatric disorder only partially overlapped across instruments. Demonstrating that self‐completed problem checklists can classify disorder with similar reliability and validity as standardized diagnostic interviews would provide a simple, brief, flexible way to measuring psychiatric disorder as both a categorical or dimensional phenomenon as well as dramatically lowering the burden and cost of assessments in epidemiological studies and clinical research.
Review of patient‐reported outcome measures for use in myotonic dystrophy type 1 patients
Authors: Symonds Tara , Randall Jason A. , Campbell Patrick 
Published: November 2016

ABSTRACTIntroductionThe heterogeneity of symptoms experienced by myotonic dystrophy type 1 (DM1) patients means patient‐reported outcome (PRO) assessments are uniquely suited to address this through questionnaires.MethodsA structured literature review of PRO measures used in DM1 populations, comparing psychometric data from this population was undertaken.ResultsOne health status measure, 3 activities of daily living (ADL) scales, 3 health‐related quality of life (HRQOL) assessments, and 5 sleep and fatigue measures have validity and reliability information from DM1 populations. The Myotonic Dystrophy Health Index and DM1 Activity and Participation Scale (DM1‐Activ) have the strongest validity and reliability evidence. The DM1‐Activc has been published recently and builds on the DM1‐Activ by adding more relevant items.ConclusionsThe PRO instruments we identified have varying psychometric evidence in DM1 populations; all require further testing to be confident of their ability to make accurate and valid measurements of symptoms, HRQOL, and ADL in a DM1 population. Muscle Nerve 56: 86–92, 2017.
Adenosine Producing Mesenchymal Stem Cells
Authors: Schuler Patrick J. , Brandau Sven 
Published: November 2016

Abstract
Recent findings support the importance of the adenosine pathway in human immunology. Tissue specific differences exist with respect to the capacity of mesenchymal stem cells (MSC) to produce immune regulatory ATP metabolites. While some MSC may produce adenosine in a cell-autonomous fashion, other types of MSC require the cooperative activity of T-cells.
A new technique for promoting cyclic utilization of cyclodextrins in biotransformation
Authors: Shen Yanbing , Yu Ziqi , Yang Xu , Wang Fang , Luo Jianmei , Wang Min 
Published: November 2016

Abstract
Cyclodextrins (CDs) can improve the productivity of steroid biotransformation by enhancing substrate solubility. CDs can be recycled by grafting them with appropriate carriers. Loofah fiber is an excellent grafting material for CDs, and can be applied to the biotransformation and recycling of β-cyclodextrin (β-CD). In this work, a technique for recycling β-CD in cortisone acetate (CA) biotransformation by Arthrobacter simplex CPCC 140451 was studied. Loofah fiber-grafted β-CD (LF-β-CD) was prepared using epichlorohydrin, which is a cross-linking agent. The grafting yield of β-CD was 74.8 mg g−1 dried fibers. LF-β-CD could increase the solubility of CA and enhance biotransformation. The initial conversion rate of CA was 1.5-fold higher than that of the blank group. LF-β-CD was also used in biocatalytic reactions for eight cycles, and it maintained the conversion ratio of CA at approximately 90%. Given the above positive results, LF-β-CD can be utilized in biotechnological recycling applications. This method can also be applied to CD derivatives and hydrophobic compounds.
Does forest fragmentation cause an increase in forest temperature?
Authors: Arroyo‐Rodríguez Víctor , Saldaña‐Vázquez Romeo A. , Fahrig Lenore , Santos Bráulio A. 
Published: November 2016

AbstractForest fragmentation is considered by many to be a primary cause of the current biodiversity crisis. The underlying mechanisms are poorly known, but a potentially important one is associated with altered thermal conditions within the remaining forest patches, especially at forest edges. Yet, large uncertainty remains about the effect of fragmentation on forest temperature, as it is unclear whether temperature decreases from forest edge to forest interior, and whether this local gradient scales up to an effect of fragmentation (landscape attribute) on temperature. We calculated the effect size (correlation coefficient) of distance from forest edge on air temperature, and tested for differences among forest types surrounded by different matrices using meta‐analysis techniques. We found a negative edge‐interior temperature gradient, but correlation coefficients were highly variable, and significant only for temperate and tropical forests surrounded by a highly contrasting open matrix. Nevertheless, it is unclear if these local‐scale changes in temperature can be scaled up to an effect of fragmentation on temperature. Although it may be valid when considering “fragmentation” as forest loss only, the landscape‐scale inference is not so clear when we consider the second aspect of fragmentation, where a given amount of forest is divided into a large number of small patches (fragmentation per se). Therefore, care is needed when assuming that fragmentation changes forest temperature, as thermal changes at forest edges depend on forest type and matrix composition, and it is still uncertain if this local gradient can be scaled up to the landscape.
Synthesis, Surface and Antimicrobial Activity of Piperidine‐Based Sulfobetaines
Authors: Wieczorek Daria , Dobrowolski Adam , Staszak Katarzyna , Kwaśniewska Dobrawa , Dubyk Patrycja 
Published: November 2016

AbstractA new method for the preparation of new heterocyclic amine surfactants based on sulfobetaines is proposed. Interfacial activities of the surfactants obtained in aqueous solution were studied by surface tension measurements. The critical micelle concentration, surface excess concentration, minimum area per surfactant molecule, and standard Gibbs energy of adsorption were determined. The adsorption properties of these compounds depend significantly on the alkyl chain length. Alkyl chain length also affects biological properties of the new surfactants, determining the minimum inhibitory concentration and size of inhibited growth zone. The compounds have high antimicrobial activity.
Temporospatial Characterization of Nutritional and Bioactive Components of Soybean Cultivars in China
Authors: Wu Tingting , Yao Yang , Sun Shi , Wang Caijie , Jia Hongchang , Man Weiqun , Fu Lianshun , Song Wenwen , Wu Cunxiang , Jiang Bingjun , Hou Wensheng , Ren Guixing , Han Tianfu 
Published: November 2016

AbstractNutritional and bioactive constituents, apart from protein and oil, have many beneficial functions and are of great importance in determining the quality and nutritional value of soybeans [Glycine max (L.) Merr.]. However, the temporospatial trends in soybean constituents have not been determined. The objective of this study was thus to identify the temporospatial trends in seed constituents among 89 widely grown soybean cultivars over a period of nine decades (1923–2007) in four soybean‐producing regions of China. A combination of analytical techniques was used to quantify eight categories of 35 seed constituents. The results include the following: (1) The temporal pattern (the genetic change) after nine decades of breeding was characterized by significantly increasing trends in the concentration of isoflavones, tocopherol, starch, sucrose, Ca, Mn, phospholipids and lectin, and decreasing trends in Zn, Cu and lutein concentrations. (2) The spatial distribution showed higher stachyose, Zn, isoflavone, saponin and lectin content in the cultivars from lower latitudes versus higher latitudes, and the content of tocopherol, carotenoid, oligosaccharides and phospholipids exhibited the reverse pattern. (3) According to principal component analysis, carotenoid, Fe and Mn, saponin components and glycitin were the most important contributors to the total variation across the 89 cultivars. These results provide us with a comprehensive profile for manipulating chemical constituents and improving various functional ingredients through breeding.
The effect of uniform electric field on the cross-stream migration of a drop in plane Poiseuille flow
Authors: Mandal Shubhadeep , Bandopadhyay Aditya , Chakraborty Suman 
Published: November 2016

The effect of a uniform electric field on the motion of a drop in an unbounded plane Poiseuille flow is studied analytically. The drop and suspending media are considered to be Newtonian and leaky dielectric. We solve for the two-way coupled electric and flow fields analytically by using a double asymptotic expansion for small charge convection and small shape deformation. We obtain two important mechanisms of cross-stream migration of the drop: (i) shape deformation and (ii) charge convection. The second one is a new source of cross-stream migration of the drop in plane Poiseuille flow which is due to an asymmetric charge distribution on the drop surface. Our study reveals that charge convection can cause a spherical non-deformable drop to migrate in the cross-stream direction. The combined effect of charge convection and shape deformation significantly alters the drop velocity, drop trajectory and steady state transverse position of the drop. We predict that, depending on the orientation of the applied uniform electric field and the relevant drop/medium electrohydrodynamic parameters, the drop may migrate either towards the centreline of the flow or away from it. We obtain that the final steady state transverse position of the drop is independent of its initial transverse position in the flow field. Most interestingly, we show that the drop can settle in an off-centreline steady state transverse position. Two-dimensional numerical simulations are also performed to study the drop motion in the combined presence of plane Poiseuille flow and a tilted electric field. The drop trajectory and steady state transverse position of the drop obtained from numerical simulations are in qualitative agreement with the analytical results.