bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jejunoileal Neuroendocrine Tumors Complicated by Intestinal Ischemic Necrosis Are Associated With Worse Overall Survival
Authors: Landau Michael , Wisniewski Stephen , Davison Jon 
Published: April 2016

Context.—Jejunoileal neuroendocrine tumors (JINETs) are slow-growing, malignant tumors that are often associated with protracted survival, despite their frequent presentation at an advanced stage. A subset of JINETs is complicated by intestinal ischemic necrosis (IIN), which leads to their initial clinical presentation.
Objective.—To assess the effect of IIN on overall survival in patients with JINETs.
Design.—Ten JINETs with IIN during a 14-year period and a control group of 52 JINETs without IIN were identified retrospectively. The hematoxylin-eosin slides and gross descriptions were reviewed, and pathologic features were assessed. Overall survival was compared between the 2 groups using the Kaplan Meier method and Cox proportional hazards model.
Results.—At 1 year postresection, only 40% (4 of 10) of the patients with IIN were alive, whereas 94% (49 of 52) of those without IIN were alive (P &lt; .001). Patients with IIN were significantly older than those without IIN (median, 83 years versus 65.5 years, P = .001). By univariate Cox proportional hazards regression, IIN was associated with a 4.30-fold increased risk of death (95% confidence interval 1.75–10.56; P = .001). When controlling for age, advanced stage (stage III or IV), tumor grade, and synchronous carcinoma in a multivariate analysis, IIN showed a trend toward prognostic significance (2.31-fold increased risk of death; 95% confidence interval, 0.85–6.27; P = .10).
Conclusions.—The pathologic identification of tumor-associated IIN portends a worse overall survival among patients with JINETs.
Molecular Subtypes of Colorectal Cancer and Their Clinicopathologic Features, With an Emphasis on the Serrated Neoplasia Pathway
Authors: Bae Jeong Mo , Kim Jung Ho , Kang Gyeong Hoon 
Published: April 2016

Context.—Colorectal cancer is a heterogeneous disease entity with 3 molecular carcinogenesis pathways and 2 morphologic multistep pathways. Right-sided colon cancers and left-sided colon and rectal cancers exhibit differences in their incidence rates according to geographic region, age, and sex. A linear tendency toward increasing frequencies of microsatellite instability–high or CpG island methylator phenotype–high cancers in subsites along the bowel from the rectum to the cecum or the ascending colon accounts for the differences in tumor phenotypes associated with these subsites. The molecular subtypes of colorectal cancers exhibit different responses to adjuvant therapy, which might be responsible for differences in subtype-specific survival.
Objectives.—To review the clinicopathologic and molecular features of the molecular subtypes of colorectal cancer generated by combined CpG island methylator phenotype and microsatellite statuses, to integrate these features with the most recent findings in the context of the prognostic implications of molecular subtypes, and to emphasize the necessity of developing molecular markers that enable the identification of adenocarcinomas involving the serrated neoplasia pathway.
Data Sources.—Based on the authors' own experimental data and a review of the pertinent literature.
Conclusions.—Because colorectal cancers arise from 2 different morphologic multistep carcinogenesis pathways with varying contributions from 3 different molecular carcinogenesis pathways, colorectal cancer is a heterogeneous and complex disease. Thus, molecular subtyping of colorectal cancers is an important approach to characterizing their heterogeneity with respect to not only prognosis and therapeutic response but also biology and natural history.
Effect of Inflammation on Fibrosis Staging Measured by Quantitative Elasticity Parameters in Rats With Immune Hepatitis
Authors: Hao Lei , Tu Ji-Zheng , Wang Xing-Hua , Shi Ying , Liu Xiao-Li , Zhang Huan-Hu 
Published: April 2016

ObjectivesTo investigate the effect of inflammation on fibrosis staging measured by quantitative elasticity parameters in rats with immune hepatitis.MethodsFifty‐two rats were injected with swine serum as a model group, whereas 8 rats were injected with saline as a control group. Rats were randomly subjected to real‐time tissue elastography biweekly. Tissue dispersion quantitative analysis was performed to obtain 12 quantitative elasticity parameters: relative mean value, standard deviation, blue area percentage, complexity, kurtosis, skewness, contrast, entropy, inverse difference moment, angular second moment, correlation, and liver fibrosis index. Subsequently, rats were euthanized, and liver specimens were taken for pathologic examination. The Kruskal‐Wallis test was used for comparisons among groups. Spearman rank correlation analysis was used for correlation analysis. Receiver operating characteristic curves were used to optimize cutoff values and evaluate the diagnostic performance of the liver fibrosis index.ResultsExcept for complexity, kurtosis, and correlation, the other 9 parameters had statistical differences (P < .05), and among these 9 parameters, the liver fibrosis index had the strongest correlation with fibrosis staging (r = 0.809; P < .05). Except for kurtosis and correlation, the other 10 parameters had statistical differences (P < .05), and among these 10 parameters, the liver fibrosis index had the highest correlation with inflammation grading (r= 0.766; P< .05). The fibrosis index cutoff values were 2.35 for stage S1 or higher (area under the curve [AUC], 0.940; sensitivity, 97.1%; specificity, 73.3%), 2.99 for stage S2 or higher (AUC, 0.865; sensitivity, 78.6%; specificity, 81.0%), 3.48 for stage S3 or higher (AUC, 0.924; sensitivity, 94.4%; specificity, 87.1%), and 4.05 for stage S4 (AUC, 0.933; sensitivity, 87.5%; specificity, 95.1%).ConclusionsReal‐time elastography could be used to noninvasively evaluate fibrosis staging in rats with immune hepatitis. However, inflammation had an effect on the accuracy of this technique.
Simulation of energy‐dependent electron diffusion processes in the Earth's outer radiation belt
Authors: Ma Q. , Li W. , Thorne R. M. , Nishimura Y. , Zhang X.‐J. , Reeves G. D. , Kletzing C. A. , Kurth W. S. , Hospodarsky G. B. , Henderson M. G. , Spence H. E. , Baker D. N. , Blake J. B. , Fennell J. F. , Angelopoulos V. 
Published: April 2016

AbstractThe radial and local diffusion processes induced by various plasma waves govern the highly energetic electron dynamics in the Earth's radiation belts, causing distinct characteristics in electron distributions at various energies. In this study, we present our simulation results of the energetic electron evolution during a geomagnetic storm using the University of California, Los Angeles 3‐D diffusion code. Following the plasma sheet electron injections, the electrons at different energy bands detected by the Magnetic Electron Ion Spectrometer (MagEIS) and Relativistic Electron Proton Telescope (REPT) instruments on board the Van Allen Probes exhibit a rapid enhancement followed by a slow diffusive movement in differential energy fluxes, and the radial extent to which electrons can penetrate into depends on energy with closer penetration toward the Earth at lower energies than higher energies. We incorporate radial diffusion, local acceleration, and loss processes due to whistler mode wave observations to perform a 3‐D diffusion simulation. Our simulation results demonstrate that chorus waves cause electron flux increase by more than 1 order of magnitude during the first 18 h, and the subsequent radial extents of the energetic electrons during the storm recovery phase are determined by the coupled radial diffusion and the pitch angle scattering by EMIC waves and plasmaspheric hiss. The radial diffusion caused by ULF waves and local plasma wave scattering are energy dependent, which lead to the observed electron flux variations with energy dependences. This study suggests that plasma wave distributions in the inner magnetosphere are crucial for the energy‐dependent intrusions of several hundred keV to several MeV electrons.
Three‐Dimensional Carbon‐Coated SnO2/Reduced Graphene Oxide Foam as a Binder‐Free Anode for High‐Performance Lithium‐Ion Batteries
Authors: Tao Huachao , Zhu Shouchao , Xiong Lingyun , Yang Xuelin , Zhang Lulu 
Published: April 2016

AbstractA three‐dimensional carbon‐coated SnO2/reduced graphene oxide (SnO2/RGO/C) foam has been prepared by using glucose as the carbon source and cross‐linking agent through a one‐step hydrothermal process followed by freeze drying. The foam, as a free‐standing anode for lithium‐ion batteries, exhibits a large capacity and excellent cycling stability (717 mAh g−1 after 130 cycles at 100 mA g−1). The outstanding electrochemical performance could be related to the synergistic effect between the nano‐sized high‐capacity SnO2, the excellent electronic conductivity and large specific surface area of RGO, and the carbon coating layer, which could enhance the bonding strength of SnO2 nanoparticles and RGO nanosheets, keep the structural integrity, and increase the electronic conductivity. The strong interaction between SnO2 and RGO, the high electronic conductivity, and the porous structure of the composite result in high electrochemical activity and stable cycling performance as a binder‐free anode for lithium‐ion batteries.
ChemInform Abstract: THE STRUCTURE OF NICKEL(II) BROMIDE IN HIGHLY CONCENTRATED AQUEOUS SOLUTION BY X‐RAY DIFFRACTION ANALYSIS
Authors: WAKITA H. , ICHIHASHI M. , MIBUCHI T. , MASUDA I. 
Published: April 2016

AbstractIn wäßrigen NiBr2 ‐Lösungen der Konzentrationen 2.004, 4.064 und 4.845 mol dm′3 liegt der inner sphere‐Komplex (I) mit Ni‐Br‐Abständen zwischen 2.52 und 2.58 Å und Ni‐OHZ‐Abständen von 2.04‐2.05 Å vor.
ChemInform Abstract: ELECTROORGANIC REACTIONS. PART 18. THE COMPETITION BETWEEN CLEAVAGE AT ARYL‐OXYGEN AND AT TETRAZOL‐5‐YL‐OXYGEN BONDS IN THE CATHODIC REDUCTION OF ARYL TETRAZOLYL ETHERS
Authors: AKBULUT U. , TOPPARE L. , UTLEY J. H. P. 
Published: April 2016

AbstractDie kathodische Spaltung der Ether (Ia) und (Ib) führt über einen 2F‐Prozeß zu den Phenolen (IIa) und (IIb), die im ersten Fall von den Kohlenwasserstoffen (IIIa) begleitet werden.
ChemInform Abstract: MODELING HETEROGENEOUS CATALYSTS WITH HOMOGENEOUS CATALYSTS. 2. MODELING CATALYTIC HYDRODENITROGENATION
Authors: LAINE R. M. , THOMAS D. W. , CARY L. W. 
Published: April 2016

AbstractIm Rahmen der Suche nach einem wirtschaftlichen Verfahren zur N‐Entfernung aus Brennstoffen wird die Wirksamkeit von Katalysatoren bei der Hydrierung von Trialkylaminen geprüft.
ChemInform Abstract: ELECTROPHILIC IPSO‐SUBSTITUTIONS. PART 2. REACTIONS OF 3‐SUBSTITUTED INDOLES AND 4‐SUBSTITUTED N,N‐DIMETHYLANILINES WITH ARENEDIAZONIUM IONS
Authors: COLONNA M. , GRECI L. , POLONI M. 
Published: April 2016

AbstractAls Zwischenprodukte bei den Reaktionen der Indole (I) und der Aniline (IV) mit Arendiazoniumkationen sind o‐Komplexe anzusehen, die unter Abspaltung der Fluchtgruppe als Kation in die entsprechenden Azoverbindungen (III) bzw. (VI) übergehen.
ChemInform Abstract: LEWIS ACID‐CATALYZED REACTIONS OF ARYL CYCLOPROPYL KETONES. SCOPE AND MECHANISM
Authors: MURPHY W. S. , WATTANASIN S. 
Published: April 2016

AbstractDie Cyclisierung der Cyclopropylketone (I) zu den Tetralonen (II) ist stark von der Substitution, der Reaktionszeit und dem Lösungsmittel (untersucht CH2C12, Nitromethan und Benzol) abhängig.
ChemInform Abstract: SYNTHESIS OF HETEROCYCLES USING A NEW IMMONIUM SALT DERIVED FROM N,N‐DIMETHYLTHIOUREA
Authors: YOKOYAMA M. , ARAI K. , IMAMOTO T. 
Published: April 2016

AbstractDas Immonium‐Salz (II) wird durch Reaktion des Thioharnstoffs (I) mit CS2 und nachfolgende Methylierung erhalten.
ChemInform Abstract: STABLE CARBOCATIONS. PART 239. PREPARATION AND CARBON‐13 AND NITROGEN‐15 NMR SPECTROSCOPIC STUDY OF CYANOCARBENIUM IONS. SUBSTITUENT EFFECTS ON THE EXTENT OF MESOMERIC NITRENIUM ION CHARACTER IN CYANODIPHENYLMETHYL CATIONS. THE SEARCH FOR RELATED STABLE α‐CYANOCARBENIUM IONS
Authors: OLAH G. A. , ARVANAGHI M. , PRAKASH G. K. S. 
Published: April 2016

AbstractBenzophenoncyanhydrin bildet bei ‐78°C in superacidem Medium das Methylkation (Ia); das Ausmaß des mesomeren Nitreniumcharakters läßt sich durch den elektronischen Effekt der p‐Substituenten in (Ib) verändern.
ChemInform Abstract: OXIDATION OF KETALS TO ORTHOCARBONATES: A DOUBLE BAEYER‐VILLIGER REACTION
Authors: BAILEY W. F. , SHIH M.‐J. 
Published: April 2016

AbstractDie Ketale bzw. die Orthoester (I), (IV), (V), (VII), (VIII) und (X) werden mit Persäure in meist exothermer Reaktion zu den Orthocarbonaten (II), (VI), (IX) und (XI) sowie zu Diethylcarbonat (III) oxidiert.
ChemInform Abstract: CATALYTIC REDUCTIVE DEBROMINATION AS A NEW METHOD OF SYNTHESIZING DEUTERO‐SUBSTITUTED THIOPHENE AND FURAN DERIVATIVES
Authors: SHARF V. Z. , BELEN'KII L. I. , GUROVETS A. S. , KARMANOVA I. B. 
Published: April 2016

AbstractDie reduktive Enthalogenierung der Bromthiophene (I) und (IIIa) sowie des Furans (IIIb) mit Wasserstoff über einem Palladiumkatalysator, der sich auf einem mit γ‐Aminopropylgruppen modifizierten Silicagelträger befindet, wird untersucht.
ChemInform Abstract: REACTION OF (9‐ANTHRYL)ARYLMETHYL CHLORIDES WITH GRIGNARD AND LITHIUM REAGENTS
Authors: TAKAGI M. , NOJIMA M. , KUSABAYASHI S. 
Published: April 2016

AbstractDie Reaktion der Anthryl‐ary1‐methylchloride (I) mit den Organometall‐Reagenzien (II) und (III) kann zu Gemischen aus den Alkylierungs‐ (IV)+(V) , Dimerisierungs‐ (VI)‐(VIII) und Reduktionsprodukten (IX)+(X) führen.
ChemInform Abstract: INTERACTION OF COPPER COMPLEXES DERIVED FROM 1,2‐QUINONE MONOOXIMES (2‐NITROSOPHENOLS) WITH AMINES
Authors: BUCKLEY R. G. , CHARALAMBOUS J. , BRAIN E. G. 
Published: April 2016

AbstractDie Reaktion von Anilin (II) mit den Cu(II)‐Komplexen (I) bzw. (V) führt zu dem Komplex‐Addukt (IIIa) bzw. zu den Naphthalin‐Derivaten (VI) + (VII); (IIIa) reagiert mit Pyridin zu dem Dipyridin‐Addukt (IIIb), aus dem der Komplex (IIIc) bzw. das Aminonaphthochinon (IV) zugänglich sind.
ChemInform Abstract: REACTIONS OF NORCARANE AND OF 2‐NORBORNENE WITH IODINE(I) AZIDE AND IODINE(I) CHLORIDE
Authors: CAMBIE R. C. , DIXON G. , RUTLEDGE P. S. , WOODGATE P. D. 
Published: April 2016

AbstractNorcaran (I) reagiert mit IN3 (erzeugt in situ aus ICI und NaN3) bzw. ICl unter Ringöffnung und/ oder Fragmentierung gefolgt von Addition zu den Produkten (II)‐(IV) bzw. (V)‐(VII), wobei die Produktverteilung vom eingesetzten Lösungsmittel beeinflußt wird.
ChemInform Abstract: ALLENES AND ACETYLENES. XXIII. SYNTHESIS OF α‐ALLENIC AMINES VIA ALLENIC IMINES OBTAINED FROM ORGANOCOPPER REACTIONS
Authors: CLAESSON A. , SAHLBERG C. 
Published: April 2016

AbstractAus dem Imin (I) und BuLi wird das Li‐ Derivat dargestellt und mit dem Komplex (II) zu dem Kupfer‐Reagenz (III) umgesetzt, das in situ mit dem Tosylat (IVa) bzw. mit den Mesylaten (IVb)‐(IVg) zu den entsprechenden α‐allenischen Iminen (V) reagiert.
ChemInform Abstract: 1,5‐BIS(TRIMETHYLSILOXY)‐1,5‐DIMETHOXY‐1,4‐PENTADIENES. CYCLOPROPANE SYNTHESIS VIA INTRAMOLECULAR COUPLING
Authors: CHAN T. H. , WALLACE H. M. 
Published: April 2016

AbstractAus den 1,3‐Dicarbonsäureestern (I) erhält man mit Lithiumdiisopropylamid und Trimethylchlorsilan die Bis‐ketenacetale (II), die mit TiCl4 zu den Cyclopropanen (III) kondensiert werden können.
ChemInform Abstract: PARTICIPATION OF THE PERCHLORATE ANION IN ADDITION REACTIONS OF ARYLTHIO CHLORIDES AND HALOGENS WITH UNSATURATED DERIVATIVES OF TRICYCLO(4.2.2.02,5)DECANE. SYNTHESIS OF STABLE COVALENT PERCHLORATES
Authors: ZEFIROV N. S. , KOZ'MIN A. S. , ZHDANKIN V. V. 
Published: April 2016

AbstractDie Reaktionen der olefinischen Tricyclodecan‐Derivate (II), (VI), (VIII) bzw. (XII) mit den Nucleophilen (I) in Gegenwart von 2, 10 oder 16 Moläquiv. Lithiumperchlorat in nichtnucleophilen Lösungsmitteln wie Diethylether, Ethylacetat oder Methylenchlorid werden untersucht; die Umsetzungen mit lod (Ia) und den Sulfenylchloriden (Id) und (Ie) werden bei 25°C, die mit Chlor (Ib) und Brom (Ic) bei ‐ 75°C durchgeführt.
ChemInform Abstract: ORGANOPALLADIUM APPROACHES TO PROSTAGLANDINS. 1. SYNTHESIS OF THIOPHENE‐CONTAINING PROSTAGLANDIN ENDOPEROXIDE ANALOGS VIA THIENYLPALLADATION OF BICYCLIC OLEFINS
Authors: LAROCK R. C. , LEACH D. R. , BJORGE S. M. 
Published: April 2016

AbstractThiophen‐acrylsäure (Ia) wird zu (Ib) verestert, bzw. zur entsprechenden Propionsäure hydriert und anschließend zu (IIa) verestert.
ChemInform Abstract: REACTION OF SOME 1,4‐BENZOQUINONE MONOOXIMES WITH METHANOLIC HYDROGEN CHLORIDE
Authors: SARGENT M. V. 
Published: April 2016

AbstractDie p‐Benzochinon‐monooxime (I) reagieren mit methanolischem HCl bei 25‐30°C zu den o‐Chloranilinen (II); unter analogen Bedingungen geben die Chinonoxime (III) bzw. (V) die o‐Chloraniline (IV) bzw. (VI).
ChemInform Abstract: SYNTHESIS AND PROPERTIES OF NUCLEAR HYDROXYLATED DERIVATIVES OF FLUFENAMIC ACID AND ETOFENAMATE
Authors: BOLTZE K.‐H. , BAECKER U. + , KREISFELD H. 
Published: April 2016

AbstractDie Trifluormethylanilinobenzoesäuren (VIII) werden auf den skizzierten Synthesewegen dargestellt.
ChemInform Abstract: MOLECULAR INCLUSION IN FUNCTIONALIZED MACROCYCLES. PART 3. SYNTHESIS, PROTON AND CARBON‐13 NMR SPECTRA, AND CONFORMATIONAL PREFERENCE OF OPEN CHAIN LIGANDS ON LIPOPHILIC MACROCYCLES
Authors: BOCCHI V. , FOINA D. , POCHINI A. , UNGARO R. , ANDREETTI G. D. 
Published: April 2016

AbstractBasen‐katalysierte Kondensation der Phenole (Ia) und (Ib) mit Formaldehyd nach der Methode von Cornforth liefert die Calix[n]arene (IIa)‐(IIc); das Analoge (IId) entsteht durch Desalkylierung von (IIb) oder (IIc) mit AlCl3 in Toluol (3 h, 20°C).
ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW β‐LACTAM AND THIAZOLIDINONES CONTAINING A SULFANILAMIDE MOIETY
Authors: HASSAN K. M. , EL‐SHAFEI A. K. , EL‐KASHEF H. S. , MASHALY M. M. 
Published: April 2016

AbstractAus den Sulfonamiden (I) und den aromatischen Aldehyden (II) werden die Schiffschen Basen (III) erhalten, aus denen mit Chloracetyl‐ Chlorid (IV) und Triethylamin die Azetidinone (V) und mit Thioglykolsäure (VI) die Thiazolidinone (VII) hergestellt werden.
ChemInform Abstract: NUCLEAR ANALOGS OF β‐LACTAM ANTIBIOTICS. 8. STEREOSPECIFIC SYNTHESIS OF A C‐3 METHOXYLATED MONOCYCLIC β‐LACTAM
Authors: DEMARINIS R. M. , BRYAN W. M. 
Published: April 2016

AbstractAus dem cis‐Azetidinon (Ia) erhält man mit Lithiummethylat und tert.‐Butylhypochlorit definiert die Methoxy‐Verbindung (Ib), die mit Persulfat direkt zu (IIa) deblockiert wird.
ChemInform Abstract: SYNTHESIS AND CNS ACTIVITY OF N,N‐DISUBSTITUTED 1‐(AMINOMETHYL)‐5‐ALKYL‐3‐(ARYLOXYACETYLHYDRAZONO)INDOLIN‐2‐ONES
Authors: AGARWAL R. , MISRA S. , SATSANGI R. K. , TIWARI S. S. 
Published: April 2016

AbstractAus Isatin (I) erhält man mit den Alkyloxyacetylhydrazinen (II) die Hydrazone (III), die mit Formaldehyd (IV) und den Aminen (V) die Mannich‐Basen (VI) ergeben.
ChemInform Abstract: SYNTHESIS OF PYRROLO(3,2‐B)INDOLE DERIVATIVES
Authors: GRINEV A. N. , RYABOVA S. YU. 
Published: April 2016

AbstractDas Hydrazon (I) des N‐Acetylindoxyls reagiert mit Ketonen (II) zu unsymmetrischen Ketazinen (III), die unter dem Einfluß von Essigsäure zu Pyrroloindolen (IV) cyclisieren.
ChemInform Abstract: POLYSUBSTITUTED PYRAZOLES. PART 3. NEW O‐ AND C‐ALLYL DERIVATIVES OF 4‐HYDROXYPYRAZOLES OF POSSIBLE BIOLOGICAL INTEREST
Authors: SOLIMAN F. S. G. , LABOUTA I. M. 
Published: April 2016

AbstractDie Allylierung der Hydroxypyrazole (I) mit Allylbromid (II) führt zu den O‐Allyl‐Verbindungen (III), die bei der Claisen‐ Umlagerung die C‐Allyl‐Verbindungen (IV) ergeben.
ChemInform Abstract: REACTIVITY AND BIOLOGICAL EFFECT IN THE THIAZOLE SERIES. PART 5. SYNTHESIS OF F Ω‐(5‐AROYL‐4‐ARYLTHIAZOL‐2‐YL)ACETOPHENONES
Authors: KREY P. , DEHNE H. 
Published: April 2016

AbstractDie N‐Acylthioacetamide (I) werden mit den Bromacetophenonen (II) zu den Thiazolen (III) umgesetzt.
ChemInform Abstract: REACTIONS OF ALDONITRONES WITH PHENYLPHOSPHONOTHIOIC DICHLORIDE AND RELATED COMPOUNDS. FORMATION OF 2‐ARYLBENZOTHIAZOLES FROM α,N‐DIARYLNITRONES
Authors: YOSHIFUJI M. , NAGASE R. , KAWASHIMA T. , INAMOTO N. 
Published: April 2016

AbstractDie Reaktion der cx‐Aryl‐N‐methylnitrone (I) mit dem Dichlorid (II) bzw. ‐monochlorid (V) liefert die Benzamide (III) und die Thiobenzamide (IV).
ChemInform Abstract: STEREOSELECTIVE REACTIONS OF CHIRAL ENOLATES. APPLICATION TO THE SYNTHESIS OF (+)‐PRELOG‐DJERASSI LACTONIC ACID
Authors: EVANS D. A. , BARTROLI J. 
Published: April 2016

AbstractAus dem chiralen Oxazolidon (I) erhält man nach vorheriger Metallierung mit Methallyliodid (II) überwiegend das Diastereomere (III) (97% im Diastereomerengemisch), das mit Lithjumalanat zum Alkohol (IV) reduziert und anschließend mit Pyridin‐Schwefeltrioxid zum Aldehyd (V) oxidiert werden kann.
ChemInform Abstract: SYNTHESIS OF N‐(CARBONYLAMINO)‐1,2,3,6‐TETRAHYDROPYRIDINES WITH ANALGESIC, ANTIINFLAMMATORY, AND HYPERGLYCEMIC ACTIVITY
Authors: YEUNG J. M. , CORLETO L. A. , KNAUS E. E. 
Published: April 2016

AbstractDurch Umsetzung der Pyridiniumverbindungen (I) mit den Carbonsäurehydraziden (II) erhält man über (III) die Pyridinium‐Ylide (IV), die zu den gesuchten Tetrahydropyridinen (V) reduziert werden.
ChemInform Abstract: 1,4‐DIHYDROPYRIDINE‐3‐ AND 3,5‐CARBOTHIOLIC ACID ESTERS
Authors: VIGANTE B. A. , OZOLS YA. YA. , DUBUR G. YA. , BEILIS YU. I. , BELASH E. M. , PREZHDO V. V. 
Published: April 2016

AbstractDurch Kondensation von β‐Aminocrotonsäureethyk, bzw. ‐S‐ethyl und ‐S‐benzylestern (I) mit α‐Alkylidenacetessigsäure‐ bzw. α‐Alkyliden‐thioacetessigsäureestern (II) werden die Dihydropyridine (III) hergestellt.
ChemInform Abstract: SYNTHESES AND REACTIONS OF PYRIDAZINE DERIVATIVES. XIV: SYNTHESES OF VINYL PYRIDAZINECARBOXYLIC ALDEHYDES
Authors: HEINISCH G. , MAYRHOFER A. , WAGLECHNER R. 
Published: April 2016

AbstractDie Pyridazinaldehyde (I) werden mit dem Wittig‐Reagenz (II) zu den trans‐konfigurierten gib‐ungesättigten Aldehyden (III) umgesetzt.
ChemInform Abstract: DIAZABICYCLOALKANES WITH NITROGEN ATOMS AT NODAL POSITIONS. 8. EFFECT OF C‐SUBSTITUENTS ON THE N‐METHYLATION OF 1,4‐DIAZABICYCLO(2.2.2)OCTANES AND DEMETHYLATION OF THEIR BISQUATERNARY SALTS
Authors: VYSOCHIN V. I. , SHISHKIN G. V. 
Published: April 2016

AbstractDie Untersuchung der Monomethylierung von Diazabicycloalkanen (I) mit Methyliodid oder Benzoesäuremethylester zeigt, daß die Methylierung mit Methyliodid ohne Einfluß der Substituenten verläuft, daß aber eine Erhöhung der Akzeptoreigenschaften der Substituenten in 2‐Stellung zu einer Verminderung der Reaktionsfähigkeit sowohl bereits bei der Monomethylierung mit Benzoesäuremethylester als auch bei der N,N′‐Dimethylierung führt.
ChemInform Abstract: 1,3‐THIAZINES. XVIII: PREPARATION OF 3‐AMINO‐2‐THIOXOTETRAHYDRO‐1,3‐THIAZIN‐4‐ONES, NOVEL CYCLIC DITHIOCARBAZATES
Authors: HANEFELD W. , GLAESKE G. , STAUDE H.‐J. 
Published: April 2016

AbstractDurch Addition von Schwefelkohlenstoff (II) an die Hydrazinderivate (I) und nachfolgende Alkylierung mit β‐Propiolactonen (III) erhält man die Dithiocarbamate (IV), die sich zu den Thiazinen (V) kondensieren lassen.
ChemInform Abstract: A NOVEL SYNTHESIS OF 3‐ARYL‐1,2,4‐BENZOTRIAZINES VIA N‐(PHENYLSULFONYL)‐N“‐ARYLBENZAMIDRAZONES
Authors: ITO S. , TANAKA Y. , KAKEHI A. 
Published: April 2016

AbstractOxidation der Sulfonylbenzamidrazone (III) ‐ zugänglich aus den Arylsulfonylbenzohydrazonoylchloriden (I) und den Anilinen (II) ‐ mit HgO liefert die Arylbenzotriazine (IV) und die Benzanilide (V).
ChemInform Abstract: Some Reactions with 6‐Phenyl‐1,2,3,4(or 2,3,4,5)‐tetrahydro‐4‐thioxo‐1,3,5‐triazin‐2‐one and Its S‐Alkylated Derivatives.
Authors: BASYOUNI M. N. , HABASHY M. M. , EL‐KHAMRY A. A. , EL‐ADLY M. M. 
Published: April 2016

AbstractDie Umsetzung der Triazinone (I) mit den sekundären Aminen (IIa)‐(IIc) führt zu den Salzen (III).
ChemInform Abstract: AZONIA‐AZULENE SALTS. PART 5. SYNTHESIS OF 5H‐PYRROLO(1,2‐A)AZEPINE AND OF 7H‐PYRROLO(1,2‐A)AZEPIN‐7‐ONE
Authors: JONES G. , RADLEY P. M. 
Published: April 2016

AbstractDie Alkene (I) reagieren mit Iodazid ‐ erzeugt aus ICI und Natriumazid ‐ zu den Addukten (II), die beim Behandeln mit KO‐tBu unter HI‐Eliminierung in die Azido‐diphenylpropene (III) übergehen.