bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anwendung der organerhaltenden Nierentumorchirurgie in der Behandlung von Patienten mit Nierenzellkarzinom im Stadium pT1/pT2 – eine unizentrische Trendanalyse
Authors: Ralla Bernhard , Buhl Stephanie , Goranova Irena , Pohle Margit , Maxeiner Andreas , Friedersdorff Frank , Magheli Ahmed , Hinz Stefan , Fuller Tom , Miller Kurt , Busch Jonas 
Published: November 2017

Zusammenfassung
Einleitung Für lokal begrenzte Nierenzellkarzinome (NZK) besteht die einzige kurative Therapie in der operativen Entfernung. Aktuelle nationale und europäische Leitlinien fordern bei kleinen Tumoren anstelle einer radikalen Nephrektomie (RN) eine organerhaltende Operation als offene oder minimal-invasive partielle Nephrektomie (PN). Ziel dieser Arbeit war es, die zeitliche Entwicklung des Verhältnisses der Anwendung von RN und PN als minimal-invasive bzw. offene Verfahren, in Abhängigkeit der Tumorstadien pT1-pT2 an unserem Zentrum zu untersuchen.
Patienten und Methoden In dieser retrospektiven Studie wurden Patienten eingeschlossen, die sich von 01/2008 bis 10/2014 wegen eines Nierenzellkarzinoms im Stadium pT1/pT2 einer chirurgischen Therapie an der Klinik für Urologie der Charité – Universitätsmedizin Berlin unterzogen. Die Patienten erhielten eine PN bzw. RN als offene (OPN bzw. ORN), laparoskopische (LPN bzw. LRN) oder Roboter-assistierte laparoskopische (RAPN) Operation. Operative Daten wurden retrospektiv aus elektronisch gespeicherten Dokumenten des Klinikinformationssystems (KIS) erhoben. Die statistische Auswertung erfolgte deskriptiv.
Ergebnisse 758 Patienten mit histopathologisch nachgewiesenem Nierenzellkarzinom im Stadium pT1 /pT2 wurden in die Studie eingeschlossen. Bei 439 Patienten (57,9 %) wurde eine PN durchgeführt, die bei 254 (57,9 %) als LPN und 185 (42,1 %) als OPN durchgeführt wurde. Bei 319 Patienten (42,1 %) wurde eine RN durchgeführt, die bei 250 Patienten (78,4 %) als LRN und bei 69 Patienten (21,6 %) als ORN durchgeführt wurde. Im untersuchten Zeitraum zeigte sich ein Trend zur PN vor allem bei den Tumorstadien pT1a und pT1b. Patienten mit einem pT2 NZK wurden zum überwiegenden Teil durch eine RN behandelt, die in 40 – 53,9 % der Fälle als LRN durchgeführt wurde.
Diskussion Zusammenfassend zeigen die Ergebnisse dieser Zentrumsanalyse eine in allen Tumorstadien häufige Anwendung von organerhaltenden bzw. minimal-invasiven Verfahren, wie von den aktuellen nationalen und europäischen Leitlinien gefordert.
Neufassung der Standard-Terminologie in der gastroenterologischen Endoskopie – Ergebnis eines Konsensusprojekts der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten
Authors: Meining Alexander , Schmidbauer Werner , Schumacher Brigitte , Denzer Ulrike , Keuchel Martin , Rosien Ulrich , Moog Gero , Götz Martin , Toermer Hans-Joachim , Jacobs Ralf , Hochberger Jürgen , von Delius Stefan , Lerch Markus , Lammert Frank , Wehrmann Till 
Published: November 2017

ZusammenfassungEine einheitliche und umfassende Terminologie ist essenziell in der korrekten Befunderfassung in der diagnostischen oder therapeutischen Endoskopie. Die bisher im deutschsprachigen Raum verfügbare Standard-Terminologie beruht auf einer im Jahr 1999 publizierten Version. Bedingt durch vielfältige Änderungen, neue Diagnosen und neue endoskopische Verfahren erfolgte koordiniert durch die Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) eine umfassende Überarbeitung und Neustrukturierung der Terminologie. Die von einzelnen Arbeitsgruppen erarbeiteten Vorgaben wurden im Konsens verabschiedet und stehen nun (als Online-Dokument unter https://doi.org/10.1055/s-0043-121167 abrufbar) zur Modifikation der gängigen EDV-Dokumentationssysteme zur Verfügung. Um eine zeitgemäße Dokumentation auch in Zukunft zu gewährleisten, wurde beschlossen, dass in jährlichem Abstand die Updates oder Neuauflagen der Dokumentations-EDV einzelner Software-Firmen auf die Vorgaben der DGVS überprüft werden.
Sichtbarkeit onkologisch-klinischer Studien bei Ärzteschaft und Prüfzentren
Authors: Zippel C , Giesel F , Kopka K , Moosmann A 
Published: November 2017

ZusammenfassungEin Schwerpunkt translationaler Forschung ist die Initiierung und Durchführung von klinischen Studien früher Phasen. In diesem Beitrag wird
dargestellt, wie durch das Kommunikationsmittel eines Studienflyers die Sichtbarkeit onkologisch-klinischer Studien erhöht und der damit
verbundene Wissenstransfer in der Ärzteschaft gezielt unterstützt und gefördert werden kann. Darüber hinaus wird am Beispiel des
prospektiven PSMA-Multicenter Trials der Phasen-I/–II diskutiert, wie durch einen Studienflyer wesentliche inhaltliche und
organisationsbezogene Eckpunkte einer klinischen Studie wie Studienziel und -design kompakt und kostengünstig in der Ärzteschaft vermittelt
werden können. Die bessere Sichtbarkeit klinischer (Forschungs-)Studien – und insbesondere akademisch getriebener prospektiver Studien in
der Ärzteschaft – kann schließlich dazu führen, dass hierfür geeignete Patienten frühzeitig in den Prüfzentren identifiziert und nach
Einwilligung unmittelbar eingeschlossen werden. Schließlich geben wir allgemeine Hinweise zu Flyeraufbau und -inhalten, die Forschergruppen
als unterstützende Hilfe bei der Erstellung von Flyern für weitere klinische Studien dienen können.
ESGE-ESGENA technical specification for process validation and routine testing of endoscope reprocessing in washer-disinfectors according to EN ISO 15883, parts 1, 4, and ISO/TS 15883-5
Authors: Beilenhoff Ulrike , Biering Holger , Blum Reinhard , Brljak Jadranka , Cimbro Monica , Dumonceau Jean-Marc , Hassan Cesare , Jung Michael , Neumann Christiane , Pietsch Michael , Pineau Lionel , Ponchon Thierry , Rejchrt Stanislav , Rey Jean-François , Schmidt Verona , Tillett Jayne , van Hooft Jeanin 
Published: November 2017

Statements
1 Prerequisites. The clinical service provider should obtain confirmation from the endoscope washer-disinfector (EWD) manufacturer that all endoscopes intended to be used can be reprocessed in the EWD.
2 Installation qualification. This can be performed by different parties but national guidelines should define who has the responsibilities, taking into account legal requirements.
3 Operational qualification. This should include parametric tests to verify that the EWD is working according to its specifications.
4 Performance qualification. Testing of cleaning performance, microbiological testing of routinely used endoscopes, and the quality of the final rinse water should be considered in all local guidelines. The extent of these tests depends on local requirements. According to the results of type testing performed during EWD development, other parameters can be tested if local regulatory authorities accept this. Chemical residues on endoscope surfaces should be searched for, if acceptable test methods are available.
5 Routine inspections. National guidelines should consider both technical and performance criteria. Individual risk analyses performed in the validation and requalification processes are helpful for defining appropriate test frequencies for routine inspections.
2.7.1 Biphasic Systems
Authors: Claver C. , Godard C. , Lombardía A. 
Published: November 2017

AbstractTo overcome the inherent issue of catalyst recycling in homogeneous catalysis, much effort has been devoted to the heterogenization of catalysts onto solid supports and to the separation of the reactants (and/or products) and the catalyst using immiscible liquid phases (liquid multiphase catalysis). For these latter systems, solvents such as water, alcohols, ionic liquids, fluorous media, supercritical fluids, and gas-expanded liquids have been employed successfully as the catalyst phase. In this chapter, the most relevant biphasic catalytic systems involving NHC complexes are discussed. Particular attention is devoted to alkene metathesis, which is considered to be one of the most important processes that uses complexes with carbene ligands. Sulfonated or related water-soluble carbene ligands are also described for biphasic reactions, such as cyclization, C–C bond formation, and hydroformylation.
Targeting Target with a 100 million dollar data breach
Authors: Pigni Federico , Bartosiak Marcin , Piccoli Gabriele , Ives Blake 
Published: November 2017

In January 2014, the CEO of the renowned U.S. discount retailer Target wrote an open letter to its customers apologizing for the massive data breach the company experienced during the 2013 holiday season. Attackers were able to steal credit card data of 40 million customers and more were probably at risk. Share prices, profits, but above all reputation were all now at stake. How did it happen? What was really stolen? What happened to the data? How could Target win consumer confidence back? While the company managed the consequences of the attack, and operations were slowly back to normal, in the aftermath the data breach costs hundreds of million dollars. Customers, banks, and all the major payment card companies took legal action against Target. Some of these litigations remained unsettled 3 years later. The importance of the breach lays in its far broader consequences, rippling through the U.S. Congress, and raising consumer and industry awareness on cyber security. The case provides substantial data and information, allowing students to step into the shoes of Target executives as they seek answers to the above questions.
Explicit formulas for 𝐶^{1,1} Glaeser-Whitney extensions of 1-Taylor fields in Hilbert spaces
Authors: Daniilidis Aris , Haddou Mounir , Le Gruyer Erwan , Ley Olivier 
Published: November 2017

We give a simple alternative proof for the

C

1
,
1

C^{1,1}

–convex extension problem which has been introduced and studied by D. Azagra and C. Mudarra (2017). As an application, we obtain an easy constructive proof for the Glaeser-Whitney problem of

C

1
,
1

C^{1,1}

extensions on a Hilbert space. In both cases we provide explicit formulae for the extensions. For the Glaeser-Whitney problem the obtained extension is almost minimal, that is, minimal up to a multiplicative factor in the sense of Le Gruyer (2009).
Presenting affine Schur algebras
Authors: Fu Qiang , Liu Mingqiang 
Published: November 2017

The universal enveloping algebra

U

(

g
l

^

n

)

\mathcal {U}(\widehat {\frak {gl}}_n)

of

g
l

^

n

\widehat {\frak {gl}}_n

was realized in [A double Hall algebra approach to affine quantum Schur–Weyl theory, Cambridge University Press, Cambridge, 2012, Ch. 6] using affine Schur algebras. In particular some explicit multiplication formulas in affine Schur algebras were derived. We use these formulas to study the structure of affine Schur algebras. In particular, we give a presentation of the affine Schur algebra

S

△

(
n
,
r

)

Q

{\mathcal S}_{{\!\vartriangle }}(n,r)_{\mathbb Q}

over

Q

\mathbb {Q}

.
The Effect of Land Access on Youth Employment and Migration Decisions: Evidence from Rural Ethiopia
Authors: Kosec Katrina , Ghebru Hosaena , Holtemeyer Brian , Mueller Valerie , Schmidt Emily 
Published: November 2017

AbstractHow does the amount of land that youth expect to inherit affect their migration and employment decisions? We explore this question in the context of rural Ethiopia using a 2014 cross‐sectional dataset indicating whether or not youth household members from a previous 2010 survey had migrated by 2014, and in which sector they worked in 2014. We estimate a household fixed effects model and exploit exogenous variation in the timing of land redistributions to overcome endogenous household decisions about how much land to bequeath to descendants. We find that larger expected land inheritances significantly lower the likelihood of long‐distance permanent migration and of permanent migration to urban areas. Inheriting more land also leads to a significantly higher likelihood of employment in agriculture and a lower likelihood of employment in the non‐agricultural sector. Conversely, the decision to attend school is unaffected. These results appear to be most heavily‐driven by males and by the older half of our youth sample. We also find suggestive evidence that several mediating factors matter. Land inheritance is a much stronger predictor of rural‐to‐urban permanent migration and non‐agricultural‐sector employment in areas with less vibrant land markets, in relatively remote areas (those far from major urban centers), and in areas with lower soil quality. Overall, these results affirm the importance of push factors in dictating occupation and migration decisions in Ethiopia.
Modeling Heterogeneous Farm Responses to European Union Biofuel Support with a Random Parameter Multicrop Model
Authors: Koutchadé Obafèmi Philippe , Carpentier Alain , Femenia Fabienne 
Published: November 2017

AbstractAlthough there is now widespread evidence of substantial variability in economic agents' responses to economic drivers in many applied economics fields, this variability has been largely overlooked by econometric agricultural production models. This article sets out to fill this gap by providing methodological contributions and empirical results. First, we consider panel data multicrop models featuring random intercept and slope parameters to account for the heterogeneous responses of crop producers to economic drivers. Second, we show that Monte Carlo expectation‐maximization algorithms are particularly well‐suited to estimating this type of model. Third, based on an application of our empirical modeling framework with a sample of French grain crop producers, we demonstrate substantial variability in farmers' responses to economic incentives. Fourth, we use the estimated model and a simple “statistical calibration” procedure to build farm‐specific simulation models, which are then used to evaluate the effects of the rapeseed price increase induced by European Union (EU) biofuel support. Our simulation results demonstrate that ignoring the variability in the considered farmers' responses to the economic incentives results in significant overestimation of the increases in rapeseed yield levels and variable input use levels induced by EU biofuel support, as well as significant underestimation of the variability in the congruent increases in rapeseed acreages.
Patient perceptions of receiving test results via online portals: a mixed-methods study
Authors: Giardina Traber D , Baldwin Jessica , Nystrom Daniel T , Sittig Dean F , Singh Hardeep 
Published: November 2017

AbstractObjectiveOnline portals provide patients with access to their test results, but it is unknown how patients use these tools to manage results and what information is available to promote understanding. We conducted a mixed-methods study to explore patients’ experiences and preferences when accessing their test results via portals.Materials and MethodsWe conducted 95 interviews (13 semistructured and 82 structured) with adults who viewed a test result in their portal between April 2015 and September 2016 at 4 large outpatient clinics in Houston, Texas. Semistructured interviews were coded using content analysis and transformed into quantitative data and integrated with the structured interview data. Descriptive statistics were used to summarize the structured data.ResultsNearly two-thirds (63%) did not receive any explanatory information or test result interpretation at the time they received the result, and 46% conducted online searches for further information about their result. Patients who received an abnormal result were more likely to experience negative emotions (56% vs 21%; P = .003) and more likely to call their physician (44% vs 15%; P = .002) compared with those who received normal results.DiscussionStudy findings suggest that online portals are not currently designed to present test results to patients in a meaningful way. Patients experienced negative emotions often with abnormal results, but sometimes even with normal results. Simply providing access via portals is insufficient; additional strategies are needed to help patients interpret and manage their online test results.ConclusionGiven the absence of national guidance, our findings could help strengthen policy and practice in this area and inform innovations that promote patient understanding of test results.
What Does the Sleeping Brain Say? Syntax and Semantics of Sleep Talking in Healthy Subjects and in Parasomnia Patients
Authors: Arnulf Isabelle , Uguccioni Ginevra , Gay Frederick , Baldayrou Etienne , Golmard Jean-Louis , Gayraud Frederique , Devevey Alain 
Published: November 2017

AbstractObjectivesSpeech is a complex function in humans, but the linguistic characteristics of sleep talking are unknown. We analyzed sleep-associated speech in adults, mostly (92%) during parasomnias.MethodsThe utterances recorded during night-time video-polysomnography were analyzed for number of words, propositions and speech episodes, frequency, gaps and pauses (denoting turn-taking in the conversation), lemmatization, verbosity, negative/imperative/interrogative tone, first/second person, politeness, and abuse.ResultsTwo hundred thirty-two subjects (aged 49.5 ± 20 years old; 41% women; 129 with rapid eye movement [REM] sleep behavior disorder and 87 with sleepwalking/sleep terrors, 15 healthy subjects, and 1 patient with sleep apnea speaking in non-REM sleep) uttered 883 speech episodes, containing 59% nonverbal utterance (mumbles, shouts, whispers, and laughs) and 3349 understandable words. The most frequent word was “No”: negations represented 21.4% of clauses (more in non-REM sleep). Interrogations were found in 26% of speech episodes (more in non-REM sleep), and subordinate clauses were found in 12.9% of speech episodes. As many as 9.7% of clauses contained profanities (more in non-REM sleep). Verbal abuse lasted longer in REM sleep and was mostly directed toward insulting or condemning someone, whereas swearing predominated in non-REM sleep. Men sleep-talked more than women and used a higher proportion of profanities. Apparent turn-taking in the conversation respected the usual language gaps.ConclusionsSleep talking parallels awake talking for syntax, semantics, and turn-taking in conversation, suggesting that the sleeping brain can function at a high level. Language during sleep is mostly a familiar, tensed conversation with inaudible others, suggestive of conflicts.
Delirium monitoring and management in the acute care setting
Authors: Cullen Elizabeth , Balas Michele C. 
Published: November 2017

Abstract:
Associated with substantial morbidity and mortality, delirium is a syndrome commonly experienced by hospitalized adults. This article presents a case study highlighting how delirium may go unrecognized by the healthcare team and provides 10 suggestions for improving delirium assessment, prevention, and management in the acute care setting.
Chromosomal Microarray Testing For Children With Unexplained Neurodevelopmental Disorders
Authors: Martin Christa Lese , Ledbetter David H. 
Published: November 2017

(Abstracted from JAMA 2017;317(24):2545–2546)
Chromosomal microarray analysis (CMA) has emerged as a robust means to detect chromosomal abnormalities including unbalanced chromosomal rearrangements, as well as smaller chromosomal abnormalities than those detectable by karyotype. Chromosomal microarray analysis has replaced conventional G-banded karyotyping due to its greater sensitivity and resolution; G-banding effectively identifies imbalances of DNA greater than 5 to 10 megabases (millions of base pairs), whereas CMA can detect genome-wide imbalances of more than 400 kilobases (thousands of base pairs).
A Retrospective Cohort Study of Hospital Versus Home Care for Pregnant Women With Preterm Prelabor Rupture of Membranes
Authors: Palmer Lynne , Grabowska Kirsten , Burrows Jason , Rowe Hilary , Billing Erin , Metcalfe Amy 
Published: November 2017

(Abstracted from Int J Gynecol Obstet 2017;137:180–184)
Pregnancies with preterm prelabor rupture of membranes (PPROM) are at risk of preterm labor, and further risks of infection or adverse cord or placental events increase perinatal morbidity and mortality. Monitoring pregnancies with PPROM in the hospital setting until at least 34 weeks is the standard practice to prevent prematurity-related complications.
Rotational Forceps Versus Manual Rotation and Direct Forceps: A Retrospective Cohort Study
Authors: O’Brien Stephen , Day Fiona , Lenguerrand Erik , Cornthwaite Katie , Edwards Sian , Siassakos Dimitrios 
Published: November 2017

(Abstracted from Eur J Obstet Gynecol Reprod Biol 2017;212:119–125)
In case of malposition, both rotational forceps (RF) and manual rotation (MR) followed by direct forceps are used to perform rotational operative vaginal birth (OVB), but evidence regarding the safest and most effective method to assist birth in such cases is still unclear. Although higher rates of complications were reported with the use of RF in the past, in recent times it has been associated with high rates of successful vaginal birth and lower rates of adverse outcomes than alternative modes of birth.
Pediatric CIDP: Clinical Features and Response to Treatment
Authors: Harada Yohei , Herrmann David N. , Logigian Eric L. 
Published: November 2017

Abstract

Objectives:
Childhood chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) responds favorably to immunomodulatory treatment. However, the optimal sequencing and selection of immunotherapy is uncertain.

Methods:
Using accepted diagnostic criteria, pediatric patients with CIDP seen at our center from 1999 to 2015 were identified retrospectively through medical record review. Clinical details and treatment responses were tabulated.

Results:
Ten patients (age 4–16, 6 women) with definite (N = 8) or possible (N = 2) CIDP met criteria. All were initially treated with IVIg; 6 responded but 4 did not. All 4 IVIG nonresponders improved with twice-weekly high-dose oral prednisone, as did 1 IVIg responder who was also treated with twice-weekly oral prednisone when IVIg was discontinued. Pulse steroids were well tolerated.

Conclusions:
Pulse oral corticosteroid therapy holds promise as an alternative treatment to IVIG in pediatric CIDP. Future multicenter studies are warranted to determine the comparative efficacy and safety of weekly pulse oral corticosteroids versus IVIg in pediatric CIDP.