bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Silver‐Mediated Oxidative Trifluoromethylation of Alcohols to Alkyl Trifluoromethyl Ethers.
Authors: Liu Jian‐Bo , Xu Xiu‐Hua , Qing Feng‐Ling 
Published: February 2016

AbstractThe practical method is efficiently applied to primary, secondary, and tertiary alcohols including natural products such as steroid, amino acid, and glucopyranose derivatives as well as complex pharmacologically relevant compounds.
ChemInform Abstract: Studies on the Synthesis of Specifically Fluorinated 4‐Aminopyridine Derivatives by Regioselective Nucleophilic Aromatic Substitution and Catalytic Hydrodefluorination.
Authors: Podolan Gabriel , Jungk Phillip , Lentz Dieter , Zimmer Reinhold , Reissig Hans‐Ulrich 
Published: February 2016

AbstractWhile pentafluoropyridine (Ib) gives always the 4‐aminated products, trifluoropyridine (Ia) gives regioisomeric mixtures favouring the 4‐aminated product in dependence of bulkiness of the secondary amine reactant.
ChemInform Abstract: Palladium‐Catalyzed Catellani ortho‐Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones.
Authors: Huang Yunze , Zhu Rui , Zhao Kun , Gu Zhenhua 
Published: February 2016

AbstractThis norbornene‐mediated acylation reaction uses acyl chlorides as acylating reagents.
ChemInform Abstract: Synthetic and Predictive Approach to Unsymmetrical Biphenols by Iron‐Catalyzed Chelated Radical—Anion Oxidative Coupling.
Authors: Libman Anna , Shalit Hadas , Vainer Yulia , Narute Sachin , Kozuch Sebastian , Pappo Doron 
Published: February 2016

AbstractAn interesting cross coupling of two different phenols is achieved in the presence of FeCl3 as catalyst in hexafluoroisopropanol as solvent to give the unsymmetrical biphenol coupling products.
ChemInform Abstract: Zinc Triflate Catalyzed C‐Benzylation: Chemo‐ and Regioselective Route to Amido Substituted Diaryl and Arylheteroarylmethanes.
Authors: Deshmukh Mahesh Subhashrao , Srivastava Ananya , Das Biswajit , Jain Nidhi 
Published: February 2016

AbstractThe para‐selective C‐benzylation of anilines with a range of electron‐rich benzyl chlorides using Zn(OTf)2 as catalyst is developed.
ChemInform Abstract: An Abnormal N‐Heterocyclic Carbene‐Based Palladium Dimer: Aqueous Oxidative Heck Coupling under Ambient Temperature.
Authors: Hota Pradip Kumar , Vijaykumar Gonela , Pariyar Anand , Sau Samaresh Chandra , Sen Tamal K. , Mandal Swadhin K. 
Published: February 2016

AbstractA novel Pd catalyst IPA is examined in the title reaction giving exclusively the E‐isomers of the cinnamic acid derivatives (III) and (V) in a E/Z‐ and regioselective manner when electron‐deficient olefins (acrylates and acrylonitrile) are used.
ChemInform Abstract: An Electrophilic Approach to the Palladium‐Catalyzed Carbonylative C—H Functionalization of Heterocycles.
Authors: Tjutrins Jevgenijs , Arndtsen Bruce A. 
Published: February 2016

AbstractThe Pd‐catalyzed carbonylation of N‐methylpyrrole (I) with aryl iodides leads to 2‐aroylpyrroles (IV), whilst the analogous reaction with o‐bromoiodobenzene (V) followed by an intramolecular arylation in an one‐pot manner gives rise to the tricyclic ketone (VI).
ChemInform Abstract: Hydrodecarboxylation of Carboxylic and Malonic Acid Derivatives via Organic Photoredox Catalysis: Substrate Scope and Mechanistic Insight.
Authors: Griffin Jeremy D. , Zeller Mary A. , Nicewicz David A. 
Published: February 2016

AbstractThe direct photolytic decarboxylation of a variety of carboxylic acids is presented.
ChemInform Abstract: KAl(SO4)2·12H2O(Alum): An Efficient Catalyst for the Synthesis of Novel Bis[spiro(quinazoline‐oxindole)] Derivatives via One‐Pot Pseudo Five‐Component Reactions.
Authors: Mohammadi Ali A. , Taheri Salman , Askari Saber , Ahdenov Reza 
Published: February 2016

AbstractThe applied catalyst can be reused at least for four times.
ChemInform Abstract: NaOH/Et3N‐Promoted Stereoselective One‐Pot Synthesis of α‐Diazo Oxime Ethers via Diazo Transfer Reaction.
Authors: Kuruba Bharath Kumar , Shariff Nusrathulla , Vasanthkumar Samuel , Emmanuvel Lourdusamy 
Published: February 2016

AbstractAn unusual synergistic effect of two base pairs, Et3N/NaOH or Py/NaOH, in the title diazo transfer reaction is observed.
ChemInform Abstract: Synthesis of Alkynyl‐Glycinols by Lewis Acid Catalyzed Propargylic Substitution of Bis‐Imidates.
Authors: Sirotkina Jekaterina , Grigorjeva Liene , Jirgensons Aigars 
Published: February 2016

AbstractA broad spectrum of bis‐imidates is prepared starting from alkynyl‐glycols.
ChemInform Abstract: Allenic Esters from Cyclopropenones by Lewis Base Catalysis: Substrate Scope, the Asymmetric Variant from the Dynamic Kinetic Asymmetric Transformation, and Mechanistic Studies.
Authors: Wei Yin , Zhao Wen‐Tao , Yang Yuan‐Liang , Zhang Zhen , Shi Min 
Published: February 2016

AbstractThe reaction of cyclopropenones (I) and (IV) with alcohols and phenols (II) is used to synthesize allenic esters (III).
ChemInform Abstract: Synthesis of Ketones Through Microwave Irradiation Promoted Metal‐Free Alkylation of Aldehydes by Activation of C(sp3)—H Bond.
Authors: Zhang Xinying , Wang Zhangxin , Fan Xuesen , Wang Jianji 
Published: February 2016

AbstractThis method for the preparation of ketones utilizes microwave irradiation promoted direct alkylation of aldehydes by activation of the inert C(sp3)‐H bond.
ChemInform Abstract: Direct Synthesis of Nitriles from Aldehydes Using an O‐Benzoyl Hydroxylamine (BHA) as the Nitrogen Source.
Authors: An Xiao‐De , Yu Shouyun 
Published: February 2016

AbstractA scalable and efficient protocol for the oxidation of multiple functionalized aldehydes to the corresponding nitriles is described, including the successful transformation of chiral and non‐chiral primary and secondary aliphatic aldehydes, dialdehydes, aromatic and hetaromatic aldehydes, 2‐substituted as well as 1,2‐and 2,2‐disubstituted alkenyl aldehydes.
ChemInform Abstract: Decarboxylative Alkylcarboxylation of α,β‐Unsaturated Acids Enabled by Copper‐Catalyzed Oxidative Coupling.
Authors: Gao Bao , Xie Yinjun , Shen Zhiqiang , Yang Lei , Huang Hanmin 
Published: February 2016

AbstractThe (E)‐selective title reaction of cinnamic acid derivatives or unsaturated ketoacids with dimethyl 2,2′‐azobis(2‐methylpropionate) is described, and depending on the electronic properties of the substituents β,γ‐unsaturated carboxylic esters are formed in low to often high yields.
ChemInform Abstract: Titanium Superoxide — A Stable Recyclable Heterogeneous Catalyst for Oxidative Esterification of Aldehydes with Alkylarenes or Alcohols Using TBHP as an Oxidant.
Authors: Dey Soumen , Gadakh Sunita K. , Sudalai A. 
Published: February 2016

AbstractAn efficient procedure is elaborated for the direct esterification of aldehydes with alcohols using titanium superoxide as heterogeneous catalyst.
ChemInform Abstract: Highly Regioselective Radical Amination of Allenes: Direct Synthesis of Allenamides and Tetrasubstituted Alkenes.
Authors: Zhang Ge , Xiong Tao , Wang Zining , Xu Guoxing , Wang Xuedan , Zhang Qian 
Published: February 2016

AbstractA wide range of terminal and internal allenes are selectively converted into allenamides or fluorinated tetrasubstituted alkenes upon reaction with N‐fluoroarylsulfonamides under mild conditions.
ChemInform Abstract: Base‐Promoted Coupling of Carbon Dioxide, Amines, and Diaryliodonium Salts: A Phosgene‐ and Metal‐Free Route to O‐Aryl Carbamates.
Authors: Xiong Wenfang , Qi Chaorong , Peng Youbin , Guo Tianzuo , Zhang Min , Jiang Huanfeng 
Published: February 2016

AbstractThe title reaction with symmetric bismesityliodonium triflate gives O‐mesityl carbamates (IV) in generally good yields.
ChemInform Abstract: Catalytic Decarboxylative Cross‐Coupling of Aryl Chlorides and Benzoates Without Activating ortho Substituents.
Authors: Tang Jie , Biafora Agostino , Goossen Lukas J. 
Published: February 2016

AbstractA bimetallic Pd(II)/Cu(I) catalytic system is included in the reaction conditions A) and found to be more active in a dilute solution.
ChemInform Abstract: Zinc Chloride Catalyzed Stereoselective Construction of Spiropyrazolone Tetrahydroquinolines via Tandem [1,5]‐Hydride Shift/Cyclization Sequence.
Authors: Zhao Tuan , Zhang Huanrui , Cui Longchen , Qu Jingping , Wang Baomin 
Published: February 2016

AbstractSpiropyrazolone tetrahydroquinoline derivatives are directly synthesized through the title reaction in good to high yields and diastereoselectivities.
ChemInform Abstract: Squaramide‐Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites.
Authors: Sun Qiang‐Sheng , Zhu Hua , Chen Yong‐Jian , Yang Xiao‐Di , Sun Xing‐Wen , Lin Guo‐Qiang 
Published: February 2016

AbstractThis method for the construction of five‐membered spirocyclic oxindoles is based on a Michael—Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine‐derived squaramide.
ChemInform Abstract: Efficient Synthesis of Tetrahydronaphthalene‐ or Isochroman‐Fused Spirooxindoles Using Tandem Reactions.
Authors: Wang Biao , Leng Hai‐Jun , Yang Xue‐Yuan , Han Bo , Rao Chao‐Long , Liu Li , Peng Cheng , Huang Wei 
Published: February 2016

AbstractA flexible and simple cascade reaction involving a Michael‐aldol or a vinylogous Henry‐acetalization relay is reported to assemble functionalized tetrahydronaphthalene (IV) and isochroman‐fused drug‐like spirocyclic scaffolds (VI).
ChemInform Abstract: Calcium‐Catalyzed Dynamic Multicomponent Reaction.
Authors: Gao Shuang , Stopka Tobias , Niggemann Meike 
Published: February 2016

AbstractAn air and moisture insensitive calcium‐based catalytic system is developed for the reversible formation of covalent bonds allowing for the diastereoselective amplification of a pharmacologically relevant bicyclic amine scaffold.
ChemInform Abstract: Silver(I)—Ferrophox Catalyzed Enantioselective Desymmetrization of Cyclopentenedione: Synthesis of Highly Substituted Bicyclic Pyrrolidines.
Authors: Das Tapas , Saha Prasenjit , Singh Vinod K. 
Published: February 2016

AbstractA scalable, operationally simple [3 + 2]‐cycloaddition reaction of cyclopentenediones with azomethine ylides is described which provides 5,5‐fused bicyclopyrrolidine derivatives with five stereocenters in moderate to high yields and with very high enantiomeric excesses.
ChemInform Abstract: 5(4H)‐Oxazolones as Novel Antitubercular Agents: Synthesis, Characterization and Structure Activity Study.
Authors: Suhasini K. P. , Chintakindi Praveen K. , Chaguruswamy K. , Murthy Y. L. N. 
Published: February 2016

Abstract5(4H)‐Oxazolone derivatives (III) are synthesized by a modified Erlenmeyer—Ploechl azlactone synthesis.
ChemInform Abstract: Iron‐Catalyzed Regioselective Direct Coupling of Aromatic Aldehydes with Coumarins Leading to 3‐Aroyl Coumarins.
Authors: Yuan Jin‐Wei , Yin Qiu‐Yue , Yang Liang‐Ru , Mai Wen‐Peng , Mao Pu , Xiao Yong‐Mei , Qu Ling‐Bo 
Published: February 2016

AbstractThe reaction conditions are also applicable to the direct coupling of N‐methylquinolines furnishing the corresponding 3‐aroylquinoline derivatives (V) in good yields.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Activation of Esters of N‐Hydroxyphthalimide: A Highly Enantioselective Route to Chiral Dihydropyridinones Bearing an All Carbon Quaternary Stereogenic Center.
Authors: Zhang Zhiming , Zeng Xiaofei , Xie Danbo , Chen Dongdong , Ding Liyuan , Wang Anna , Yang Limin , Zhong Guofu 
Published: February 2016

AbstractThe [3 + 3]‐cyclization reaction of N‐hydroxyphthalimide acrylates with N‐tosyl ketimines proceeds in moderate to high yields and with excellent enantiomeric excess.
ChemInform Abstract: Efficient Organocatalytic Construction of C4‐Alkyl Substituted Piperidines and Their Application to the Synthesis of (+)‐α‐Skytanthine.
Authors: Shiomi Shinya , Sugahara Erika , Ishikawa Hayato 
Published: February 2016

AbstractThe scalable three‐step reaction sequence of thiomalonamates and functionalized α,β‐unsaturated aldehydes in the presence of a chiral prolinol‐derived catalyst delivers the title products in high yields and with very high enantiomeric excesses.
ChemInform Abstract: Two New Dyes with Carboxypyridinium Regioisomers as Anchoring Groups for Dye‐Sensitized Solar Cells.
Authors: Mordini Alessandro , et al.  
Published: February 2016

AbstractThree‐step preparations of the new dyes DF39A (I) and DF39C (II) and their spectroscopic as well as electrochemically properties are described.
ChemInform Abstract: Construction of 3,5‐Dinitrated 1,4‐Dihydropyridines Modifiable at 1,4‐Positions by a Reaction of β‐Formyl‐β‐nitroenamines with Aldehydes.
Authors: Asahara Haruyasu , Hamada Mai , Nakaike Yumi , Nishiwaki Nagatoshi 
Published: February 2016

AbstractA variety of 2,6‐unsubstituted 3,5‐dinitro‐dihydropyridines is obtained under metal‐free and environmentally benign reaction conditions.
ChemInform Abstract: Quinolines Formation by Condensation of Heteroaromatic Ketones and 2‐Aminobenzophenones under MW Irradiation.
Authors: Cho Soo Kyung , Song Ju Hyun , Lee Eon Jin , Lee Do‐Hun , Hahn Jung‐Tai , Jung Dai‐Il 
Published: February 2016

AbstractThe title quinolines are obtained from benzophenones and heteroaromatic ketones by Friedlaender condensation.
ChemInform Abstract: Regioselective Synthesis of Indolizines, Pyrrolo[2,1‐a]isoquinolines, and Quinolines
Authors: Hashemi Seyed Abolghasem , Khalili Gholamhossein 
Published: February 2016

Abstractvia PPh3‐mediated reactions of corresponding N‐substituted pyridinium/quinolinium salts with propiolates (II)
ChemInform Abstract: Synthesis of Aza and Carbocyclic β‐Carbolines for the Treatment of Alcohol Abuse. Regiospecific Solution to the Problem of 3,6‐Disubstituted β‐ and Aza‐β‐carboline Specificity.
Authors: Phani Babu Tiruveedhula V. V. N. , Methuku Kashi Reddy , Deschamps Jeffrey R. , Cook James M. 
Published: February 2016

AbstractAn improved method is elaborated for the synthesis of azacarbolines (IV) and carbolines (VII) by a Buchwald—Hartwig amination followed by an intramolecular Heck‐type cyclization.
ChemInform Abstract: Enantioselective Synthesis of 3‐Arylquinazolin‐4(3H)‐ones via Peptide‐Catalyzed Atroposelective Bromination.
Authors: Diener Matthew E. , Metrano Anthony J. , Kusano Shuhei , Miller Scott J. 
Published: February 2016

AbstractA tertiary amine‐containing β‐turn peptide is developed and used as catalyst for the atroposelective bromination of various quinazolinones with high levels of enantioinduction.
ChemInform Abstract: Functionalization of Styrenes by Copper‐Catalyzed Borylation/ortho‐Cyanation and Silver‐Catalyzed Annulation Processes.
Authors: Zhao Wanxiang , Montgomery John 
Published: February 2016

AbstractVarious vinyl arene substrates undergo copper‐catalyzed hydroboration of the alkene and ortho cyanation of the benzene unit.
ChemInform Abstract: Ynones Merge Activation/Conjugate Addition of Chalcogenoborates ArE‐Bpin (E: Se, S).
Authors: Civit Marc G. , Sanz Xavier , Vogels Christopher M. , Bo Carles , Westcott Stephen A. , Fernandez Elena 
Published: February 2016

AbstractThe pull‐push effect of the Bpin moiety is applied in the addition of substrates (II) and (IV) to ynones (I) favouring the Z isomers of resulting β‐sulfanyl/selenyl‐enones.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Taiwaniaquinol F and Related Taiwaniaquinoids.
Authors: Kakde Badrinath N. , Kumari Pooja , Bisai Alakesh 
Published: February 2016

AbstractA Nazarov‐type cyclization of aryldienyl carbinols is used as key‐step in the synthesis of racemic taiwaniaquinol F (III) and related products.
ChemInform Abstract: Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae).
Authors: Silva Carmelita G. , Santos Junior Helvecio M. , Barbosa Jussara P. , Costa Gisela L. , Rodrigues Felipe A. R. , Oliveira Denilson F. , Costa‐Lotufo Leticia V. , Alves Ruy J. V. , Eleutherio Elis C. A. , Rezende Claudia M. 
Published: February 2016

AbstractA new halimane diterpene is isolated from Vellozia kolbekii Alves (Velloziaceae) and identified as (5R,8R,9S,13R)‐halim‐1,10‐ene‐15,16‐diol.
ChemInform Abstract: Large Micro‐Sized K2TiF6:Mn4+ Red Phosphors Synthesised by a Simple Reduction Reaction for High Colour‐Rendering White Light‐Emitting Diodes.
Authors: Han Tao , Lang Tianchun , Wang Jun , Tu Mingjing , Peng Lingling 
Published: February 2016

AbstractLarge K2TiF6:Mn4+ particles of 50‐100 μm size are prepared by direct Mn reduction from a purple aqueous solution containing KMnO4, KF, and K2TiF6 in HF to which a 10% H2O2 solution is added slowly.
ChemInform Abstract: Synthesis, Structure and Properties of a Co‐Crystallized Complex Based on Polyoxovanadate [VIV12VV6O42] 6‐ and a Mononuclear Vanadium Complex [VON(CH2CH2O)3].
Authors: Wang Lijuan , Fan Huitao , Du Chaojun , Xing Xiaojing , Zhao Yingying , Chen Baokuan , Wang Liya 
Published: February 2016

AbstractThe co‐crystallized compound (III), based on mixed valence polyoxovanadate [VIV12VV6O42] 6‐ and compound (IV) are solvothermally synthesized and characterized by single crystal XRD, IR, XPS, and magnetic and luminescence measurements.
Oxygen consumption rate model in HCl oxidation over a supported CuO‐CeO2 composite oxide catalyst under lean oxygen condition
Authors: Dai Yong , Fei Zhaoyang , Xu Xihua , Chen Xian , Tang Jihai , Cui Mifen , Qiao Xu 
Published: February 2016

AbstractLean‐oxygen oxidation of HCl, in which O2 conversion can reach as high as ∼60 to ∼90 %, can greatly simplify the process of recycling Cl2 using gas‐phase catalysis technology. The O2 consumption rate in lean‐oxygen HCl oxidation over a supported CuO‐CeO2 composite oxide catalyst was studied using an integral tube reactor. After eliminating the diffusion effects, three empirical kinetic models were proposed, which assumed O2 adsorption, surface reaction, and Cl2 desorption as the rate‐controlling steps, respectively. Based on O2 adsorption as the rate‐controlling step, the results indicate that the kinetic Model I best describes the coincidence between the predicted results and the experimental data. The results laid an essential foundation for reactor simulation, scale‐up, and optimization of the industrial process.
The Role of the Myocardial Microvasculature in Mental Stress–Induced Myocardial Ischemia
Authors: Ma Huan , Guo Lan , Huang Daozheng , Wang Lei , Guo Liheng , Geng Qingshan , Zhang Minzhou 
Published: February 2016

ABSTRACTThere is increasing evidence that mental stress can manifest as physical diseases. One such condition is mental stress–induced myocardial ischemia (MSIMI); a silent, transient, myocardial ischemic response to stressful conditions. We propose that the cardiac microvasculature may be an important site for the interplay between mental stress and MSIMI. This study is a review of the literature discussing the prevalence and emerging mechanisms underlying MSIMI. We identified several aspects underlying MSIMI, including psychological, genetic, and physiological causes. Several sources suggested that dysfunctional cardiac microvasculature might be a contributing factor in the development of stress‐induced myocardial ischemia. The literature also suggested that although MSIMI has distinct features and pathophysiology, its occurrence might indicate an increased future risk of cardiovascular events. We found that dysfunctional cardiac microvasculature may be the key point of interaction between mental stress and transient myocardial ischemia and that the development of MSIMI might be a “silent” indicator for future cardiac events.
Activated‐Carbon‐Templated Crystalline Tantalates for Photocatalytic Water Splitting
Authors: Grewe Tobias , Tüysüz Harun 
Published: February 2016

AbstractHerein, we report a facile nanocasting route for the preparation of crystalline mesoporous Ta2O5 and NaTaO3 with a high surface area using activated carbon as the structure‐directing hard template. The crystalline particles of Ta2O5 and NaTaO3 have mean sizes of 6 and 9 nm, constructing mesoporous networks with surface areas of 91 and 75 m2 g−1, respectively. The photocatalytic performances of the tantalum‐based replicas were investigated for the water splitting reaction by using methanol as sacrificial agent and better photocatalytic performances were observed in comparison with bulk and amorphous counterparts. Loading the templated Ta2O5 and NaTaO3 with 1 wt % NiOx boosted their photocatalytic activity. The most‐active sample, NaTaO3/NiOx, was also tested for overall water splitting and it produced hydrogen and oxygen in stoichiometric ratios at rates of 129 and 66 μmol h−1, respectively.
Niobium Doping Enhances Charge Transport in TiO2 Nanorods
Authors: Wang Hsin‐Yi , Yang Hongbin , Zhang Liping , Chen Jiazang , Liu Bin 
Published: February 2016

AbstractThe charge‐transport behavior of nanostructured titanium dioxide (TiO2) is of great interest because of the wide range of applications. In this work, we demonstrate a facile approach to improve electron transport in TiO2 nanorods (NRs) by introducing niobium (Nb) dopant into the lattice of TiO2. The TiO2‐NRs doped with Nb were grown directly on fluorine doped tin oxide (FTO) substrates by a facile hydrothermal method and used directly as the photoanodes for water oxidation. The TiO2 nanorod electrode doped with 0.25 % of Nb showed 65 % improvement in photocurrent as compared with the pristine TiO2 nanorod electrode. Furthermore, by simply changing the light illuminating direction, the improvement of charge transport induced by Nb doping could be easily identified.
Effect of Confinement on the Properties of Sequestered Mixed Polar Solvents: Enzymatic Catalysis in Nonaqueous 1,4‐Bis‐2‐ethylhexylsulfosuccinate Reverse Micelles
Authors: Durantini Andres M. , Falcone R. Dario , Silber Juana J. , Correa N. Mariano 
Published: February 2016

AbstractThe influence of different glycerol, N,N‐dimethylformamide (DMF) and water mixtures encapsulated in 1,4‐bis‐2‐ethylhexylsulfosuccinate (AOT)/n‐heptane reverse micelles (RMs) on the enzymatic hydrolysis of 2‐naphthyl acetate by α‐chymotrypsin is demonstrated. In the case of the mixtures with DMF and protic solvents it has been previously shown, using absorption, emission and dynamic light‐scattering techniques, that solvents are segregated inside the polar core of the RMs. Protic solvents anchor to the AOT, whereas DMF locates to the polar core of the aggregate. Thus, DMF not only helps to solubilize the hydrophobic substrate, increasing its effective concentrations but surprisingly, it does not affect the enzyme activity. The importance of ensuring the presence of RMs, encapsulation of the polar solvents and the corrections by substrate partitioning in order to obtain reliable conclusions is highlighted. Moreover, the effect of a constrained environment on solvent–solvent interactions in homogenous media and its impact on the use of RMs as nanoreactors is stressed.