bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation of a nucleoplasmic reticulum requires de novo assembly of nascent phospholipids and shows preferential incorporation of nascent lamins
Authors: Drozdz Marek M. , Jiang Haibo , Pytowski Lior , Grovenor Chris , Vaux David J. 
Published: August 2017

AbstractStructure of interphase cell nuclei remains dynamic and can undergo various changes of shape and organisation, in health and disease. The double-membraned envelope that separates nuclear genetic material from the rest of the cell frequently includes deep, branching tubular invaginations that form a dynamic nucleoplasmic reticulum (NR). This study addresses mechanisms by which NR can form in interphase nuclei. We present a combination of Nanoscale Secondary Ion Mass Spectrometry (NanoSIMS) approach and light microscopy techniques to follow formation of NR by using pulse-chase experiments to examine protein and lipid delivery to nascent NR in cultured cells. Lamina protein incorporation was assessed using precursor accumulation (for lamin A) or a MAPLE3 photoconvertible tag (for lamin B1) and membrane phospholipid incorporation using stable isotope labelling with deuterated precursors followed by high resolution NanoSIMS. In all three cases, nascent molecules were selectively incorporated into newly forming NR tubules; thus strongly suggesting that NR formation is a regulated process involving a focal assembly machine, rather than simple physical perturbation of a pre-existing nuclear envelope.
Vibronic Boson Sampling: Generalized Gaussian Boson Sampling for Molecular Vibronic Spectra at Finite Temperature
Authors: Huh Joonsuk , Yung Man-Hong 
Published: August 2017

AbstractMolecular vibroic spectroscopy, where the transitions involve non-trivial Bosonic correlation due to the Duschinsky Rotation, is strongly believed to be in a similar complexity class as Boson Sampling. At finite temperature, the problem is represented as a Boson Sampling experiment with correlated Gaussian input states. This molecular problem with temperature effect is intimately related to the various versions of Boson Sampling sharing the similar computational complexity. Here we provide a full description to this relation in the context of Gaussian Boson Sampling. We find a hierarchical structure, which illustrates the relationship among various Boson Sampling schemes. Specifically, we show that every instance of Gaussian Boson Sampling with an initial correlation can be simulated by an instance of Gaussian Boson Sampling without initial correlation, with only a polynomial overhead. Since every Gaussian state is associated with a thermal state, our result implies that every sampling problem in molecular vibronic transitions, at any temperature, can be simulated by Gaussian Boson Sampling associated with a product of vacuum modes. We refer such a generalized Gaussian Boson Sampling motivated by the molecular sampling problem as Vibronic Boson Sampling.
Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
Authors: Wang Li , Yin Mingru , Liu Yali , Chen Qiuju , Wang Yun , Ai Ai , Fu Yonglun , Yan Zhiguang , Jin Wei , Long Hui , Lyu Qifeng , Kuang Yanping 
Published: August 2017

AbstractAmong women undergoing IVF, high BMI negatively affects pregnancy outcomes when using the conventional ovary stimulating protocols combined with fresh embryo transfer. Therefore, finding a proper treatment for these high BMI women is more important and urgent when obesity is prevalent. In our study, we reported a retrospective study of 4457 women who were divided into normal BMI group (18.5 kg/m2–24.9 kg/m2) and high BMI group (≥25 kg/m2) undergoing 4611 IVF treatment cycles with frozen embryo transfer (FET). We found the high BMI group originally had the poor oocytes performance, but after FET they got the similar pregnancy outcomes as the normal BMI group. Then under FET we analyzed the IVF outcomes of our new progestin-primed ovary stimulation (PPOS) protocol, indicating that the hMG + MPA (4 or 10 mg/d) groups had the obvious better pregnancy results than the conventional short group in the high BMI group, and binary logistic regression analysis showed the hMG + MPA (10 mg/d) group was associated with better pregnancy outcomes than the hMG + MPA (4 mg/d) group. These results indicate PPOS - hMG + MPA (10 mg/d) combined with FET might be a new potential treatment choice for the high BMI women undergoing IVF treatments.
RETRACTED ARTICLE: Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b
Authors: Niu Ruichao , Xiao Xuping , Liu Bin , Li Yunqiu , zhong Yu , Ma Lijuan 
Published: August 2017

AbstractMicroRNAs (miRNAs) play powerful roles in immune function by regulating target genes that mediate cell behavior. It is well known that mast cells have essential effector and immune regulatory functions in IgE-associated allergic disorders and in innate and adaptive immune responses. However, the role of miRNAs in mediating mast cell functions and the relevant mechanisms require further exploration. The roles of miR-33b in airway inflammation and mast cell functions are still unknown. To examine the role of miR-33b in mouse mast cells in cockroach allergen-induced asthma, we developed a lentiviral system for miRNA-33b overexpression to examine whether miRNA-33b mediates airway inflammation by regulating mast cell function and to evaluate the underlying mechanism. The results showed that miR-33b inhibited cockroach allergen-induced asthma in vivo: in particular, it inhibited TH2 cytokine production. In addition, we found that in cells in which miRNA-33b had been transfected, mast cell degranulation was inhibited through suppression of the calcium release and IgE/FcεRI pathway. Our study provides new insight into the roles of miR-33b in asthma and mast cell biology and identifies novel mechanisms that may contribute to mast cell-related pathological conditions in airway inflammation.
Helical and skyrmion lattice phases in three-dimensional chiral magnets: Effect of anisotropic interactions
Authors: Chen J. , Cai W. P. , Qin M. H. , Dong S. , Lu X. B. , Gao X. S. , Liu J.-M. 
Published: August 2017

AbstractIn this work, we study the magnetic orders of a classical spin model with anisotropic exchanges and Dzyaloshinskii-Moriya interactions in order to understand the uniaxial stress effect in chiral magnets such as MnSi. Variational zero temperature calculations demonstrate that various helical orders can be developed depending on the interaction anisotropy magnitude, consistent with experimental observations at low temperatures. Furthermore, the uniaxial stress induced creation and annihilation of skyrmions can be also qualitatively reproduced in our Monte Carlo simulations. Our work suggests that the interaction anisotropy tuned by applied uniaxial stress may play an essential role in modulating the magnetic orders in strained chiral magnets.
Broadband All-angle Negative Refraction by Optimized Phononic Crystals
Authors: Li Yang Fan , Meng Fei , Zhou Shiwei , Lu Ming-Hui , Huang Xiaodong 
Published: August 2017

AbstractAll-angle negative refraction (AANR) of phononic crystals and its frequency range are dependent on mechanical properties of constituent materials and their spatial distribution. So far, it is impossible to achieve the maximum operation frequency range of AANR theoretically. In this paper, we will present a numerical approach for designing a two-dimensional phononic crystal with broadband AANR without negative index. Through analyzing the mechanism of AANR, a topology optimization problem aiming at broadband AANR is established and solved by bi-directional evolutionary structural optimization method. The optimal steel/air phononic crystal exhibits a record AANR range over 20% and its refractive properties and focusing effects are further investigated. The results demonstrate the multifunctionality of a flat phononic slab including superlensing effect near upper AANR frequencies and self-collimation at lower AANR frequencies.
In Vivo Ribbon Mobility and Turnover of Ribeye at Zebrafish Hair Cell Synapses
Authors: Graydon Cole W. , Manor Uri , Kindt Katie S. 
Published: August 2017

AbstractRibbons are presynaptic structures that mediate synaptic vesicle release in some sensory cells of the auditory and visual systems. Although composed predominately of the protein Ribeye, very little is known about the structural dynamics of ribbons. Here we describe the in vivo mobility and turnover of Ribeye at hair cell ribbon synapses by monitoring fluorescence recovery after photobleaching (FRAP) in transgenic zebrafish with GFP-tagged Ribeye. We show that Ribeye can exchange between halves of a ribbon within ~1 minute in a manner that is consistent with a simple diffusion mechanism. In contrast, exchange of Ribeye between other ribbons via the cell’s cytoplasm takes several hours.
Suppression of diabetic retinopathy with GLUT1 siRNA
Authors: You Zhi-Peng , Zhang Yu-Lan , Shi Ke , Shi Lu , Zhang Yue-Zhi , Zhou Yue , Wang Chang-yun 
Published: August 2017

AbstractTo investigate the effect of glucose transporter-1 (GLUT1) inhibition on diabetic retinopathy, we divided forty-eight mice into scrambled siRNA, diabetic scrambled siRNA, and GLUT1 siRNA (intravitreally injected) groups. Twenty-one weeks after diabetes induction, we calculated retinal glucose concentrations, used electroretinography (ERG) and histochemical methods to assess photoreceptor degeneration, and conducted immunoblotting, leukostasis and vascular leakage assays to estimate microangiopathy. The diabetic scrambled siRNA and GLUT1 siRNA exhibited higher glucose concentrations than scrambled siRNA, but GLUT1 siRNA group concentrations were only 50.05% of diabetic scrambled siRNA due to downregulated GLUT1 expression. The diabetic scrambled siRNA and GLUT1 siRNA had lower ERG amplitudes and ONL thicknesses than scrambled siRNA. However, compared with diabetic scrambled siRNA, GLUT1 siRNA group amplitudes and thicknesses were higher. Diabetic scrambled siRNA cones were more loosely arranged and had shorter outer segments than GLUT1 siRNA cones. ICAM-1 and TNF-α expression levels, adherent leukocyte numbers, fluorescence leakage areas and extravasated Evans blue in diabetic scrambled siRNA were higher than those in scrambled siRNA. However, these parameters in the GLUT1 siRNA were lower than diabetic scrambled siRNA. Together, these results demonstrate that GLUT1 siRNA restricted glucose transport by inhibiting GLUT1 expression, which decreased retinal glucose concentrations and ameliorated diabetic retinopathy.
Anti-inflammatory effect of hydroxyproline-GQDGLAGPK in desiccation stress-induced experimental dry eye mouse
Authors: Lee Hyesook , Kim Chae Eun , Ahn Byul-Nim , Yang Jaewook 
Published: August 2017

AbstractThe purpose of this study has been the investigation of the effect of novel peptide hydroxyproline-GQDGLAGPK (Hyp-GQDGLAGPK) in desiccation stress-induced dry eye mouse model and compared medicines for dry eye disease including cyclosporine, diquafosol and sodium hyaluronate. Seventy eight NOD.B10.H2
b
mice were injected with scopolamine and exposed to an air draft for 10 days, and then the mice were treated with normal saline (n = 13), 1% Hyp-GQDGLAGPK (n = 13), 0.05% cyclosporine (n = 13), 3% diquafosol (n = 13), and 0.1% hyaluronate (n = 13) for 10 days. Thirteen mice were used for histopathologic analysis at DS 10d. The desiccation stress significantly decreased tear production, but the topical treatment of Hyp-GQDGLAGPK recovered to the baseline levels, which was similar to cyclosporine and diquafosol. In addition, Hyp-GQDGLAGPK improved facilitating epithelium stabilization including the corneal irregularity score, fluorescein score and detachment of the corneal epithelium. These improvements in stabilization of the corneal epithelium was superior to that in the cyclosporine and sodium hyaluronate groups. Furthermore, desiccation stress markedly induced expression of autoimmune inflammation-related factors in the lacrimal glands, but it was significantly suppressed by Hyp-GQDGLAGPK treatment. Overall, we found that novel peptide Hyp-GQDGLAGPK has multi-functional effects such as stabilizing the tear film and inhibiting inflammation.
Junction‐less charge plasma TFET with dual drain work functionality for suppressing ambipolar nature and improving radio‐frequency performance
Authors: Tirkey Sukeshni , Raad Bhagwan Ram , Gedam Anju , Sharma Dheeraj 
Published: August 2017

This work deals with a distinct concept to realise the junction‐less tunnel field effect transistor (JL TFET) by creating the plasma of charges. The crux of this study is to reduce ambipolar conduction and to improve high‐frequency figure of merits. To construct a JL TFET, initially silicon film is considered and then metal electrodes are used to form drain and channel region. The drain electrode is separated into two sections and the work function of section adjacent to channel is selected higher than the other section. This provides a non‐uniform doping profile in the drain region creating large barrier at the drain/channel junction to prevent the ambipolar conduction. Ambipolarity is reduced to from at . The selection of work function and length of drain electrode adjunct to channel is crucial for optimising device performance. This optimisation provides information that work function >4.0 eV and length = 10 nm completely suppresses the ambipolarity which is around with little degradation in ON‐current. The high work function for the section of drain electrode adjunct to channel provides lower gate‐to‐drain capacitance () and superior high‐frequency responses. Furthermore, performance assessment at circuit level is done by implementing primary digital circuits as inverter and NAND logic with lookup table based Verilog‐A model.
Fabrication of TiO2‐WO3 hollow spheres via a templating technique for photocatalytic applications
Authors: Deng Anquan , Zhu Yufu , Zhou Lei , Lin Yuebin 
Published: August 2017

TiO2‐WO3 hollow spheres were successfully fabricated by a two‐step synthesis method, which combines the polystyrene template‐assisted method and chemical deposition method. Scanning electron microscope, energy dispersive spectrometer, and X‐ray diffractometer were used to characterise the obtained products. The results indicate that the as‐fabricated nanocomposites are double‐shelled TiO2‐WO3 hollow spherical structures. The photocatalytic properties of the obtained products were determined by the degradation of rhodamine B aqueous solution under simulated solar irradiation. The results reveal that the TiO2‐WO3 hollow spheres and pure TiO2 hollow spheres all have superior photocatalytic degradation ability. Compared with P25 nanoparticles and TiO2 hollow spheres, TiO2‐WO3 hollow spheres exhibit the best photocatalytic performance.
Deep insight into linearity and NQS parameters of tunnel FET with emphasis on lateral straggle
Authors: Ghosh Sayani , Koley Kalyan , Sarkar Chandan K. 
Published: August 2017

Tunnel field‐effect transistor (TFET) is considered to have superior device performance compared with DG‐metal–oxide–semiconductor FET in terms of reduced off‐state current and lower subthreshold swing. However, performance of a device solely depends on the accuracy in the fabrication process. This work presents a systematic methodology in small‐signal‐radio‐frequency (RF) and linearity domain to analyse the effect of variation in lateral straggle caused by the variation tilt angle during ion implantation process. From previously published researches, it is intuitively established fact that the accurate evaluation of intrinsic components and estimation of linearity in short channel devices is crucial to access the range of application of the device. In this work, the authors have investigated the RF intrinsic parameter performances of a silicon double gate TFET having variation in lateral straggle from 1 to 5 nm. This study includes the analysis of non‐quasi‐static RF bias‐dependent parameters such as intrinsic capacitances (Cgs, Cgd), gate‐to‐drain intrinsic resistance (Rgd) and intrinsic time delay (τ). Similarly, the device linearity and reliability are investigated here in terms of higher‐order transconductances (gm2 and gm3), VIP2, VIP3, IMD3, IIP3 and 1 dB compression point.
Influence of interface wettability on normal and explosive boiling of ultra‐thin liquid films on a heated substrate in nanoscale: a molecular dynamics study
Authors: Zhang Haiyan , Li Cunhui , Zhao Meiwen , Zhu Yingmin , Wang Weidong 
Published: August 2017

Wettability, as one of the important properties of solid surface, may influence heat and mass transfer in boiling process. Molecular dynamics method is employed to investigate the effects of wettability on normal and explosive boiling of ultra‐thin liquid argon film absorbed on a heated solid aluminium surface in a confined space in present work. The initial three‐phase molecular system is comprised of solid aluminium wall, liquid argon and vapour argon and is run for three different solid–liquid interfacial wettability (lyophilic, lyophobic and neutral surfaces), which achieves a balance at 90 K. After equilibrium period, two different jump temperatures degree, 150 and 350 K, are set on heat source layers separately to characterise the boiling phenomena, namely, low‐temperature degree for normal boiling and high‐temperature degree for explosive boiling in which temperature of solid wall is far beyond the critical temperature of liquid argon. The simulation results indicate that the wetting condition of solid–liquid interfacial surface have significant effects on both cases of boiling phenomena. Furthermore, the heat transfer rate with good wettability (lyophilic) is much higher than bad wettability (lyophobic) with same jump temperature degree.
Formation of gold nanoparticle dimers on silicon by sacrificial DNA origami technique
Authors: Yamashita Naoki , Ma Zhipeng , Park Seongsu , Kawai Kentaro , Hirai Yoshikazu , Tsuchiya Toshiyuki , Tabata Osamu 
Published: August 2017

To create a nanogap‐based device for single‐molecule label‐free detection using surface‐enhanced Raman spectroscopy (SERS), a new approach utilising DNA origami (DO) as a sacrificial nanostructure is proposed. In this approach, 15‐nm diameter gold nanoparticles (AuNPs) are precisely self‐assembled to form a dimer structure on opposite faces of a rectangular DO structure. The AuNPs are then fixed on a silicon chip supporting an amino‐terminated monolayer and the DO is selectively removed by vacuum ultraviolet (VUV) treatment followed by ultrapure water cleaning. X‐ray photoelectron spectroscopy measurements confirmed the successful removal of the DNA nanostructures and the VUV treatment had little effect on the diameter of the AuNPs. Quantitative evaluations showed that the original gap distance of about 3.8 nm was reduced to <2 nm after the DO structures were removed by the VUV treatment and ultrapure water rinse. The proposed technique can therefore be considered a simple and low‐cost alternative to EB lithography approaches.
Single-Stage Surgery Using Calcium Sulfate Pellets in Association with Tumor Resection as Treatment for Intraosseous Hemangioma of the Radius Shaft in a 2-Year-Old Boy
Authors: Andreacchio Antonio , Alberghina Flavia , Giacometti Vanessa , Marengo Lorenza , Canavese Federico 
Published: August 2017

AbstractIntraosseous hemangiomas are uncommon benign vascular tumors. Here the authors report a case of intraosseous hemangioma of the radial shaft in a 2-year-old boy, surgically treated by tumor mass resection and application of calcium sulfate pellets with no signs of relapse over a 2-year follow-up. Moreover, the lesion healed with new bone formation, and the last plain radiographs suggested homogenous normal trabecular bone density. The radius grew in length and remodeled to an almost normal shape. Clinically, elbow flexion-extension and forearm pronation and supination were within normal limits at the last follow-up visit.This report points to calcium sulfate pellets as a valid alternative to autologous bone grafting as void filler in large bone defects. Calcium sulfate pellets enable fast osteoinduction without interfering in follow-up imaging.
ESC-Leitlinie 2016 – Herzinsuffizienz
Authors: Adrian Lucas , Werner Christian , Laufs Ulrich 
Published: August 2017

Was ist neu?
Neue Einteilung Die neuen Leitlinien der Europäischen Gesellschaft für Kardiologie (ESC) unterscheiden eine Herzinsuffizienz (HF) mit reduzierter (HRrEF), mittelgradig eingeschränkter (HFmrEF) und erhaltener (HFpEF) Ejektionsfraktion (EF).
Diagnostik Für Patienten mit Verdacht auf Herzinsuffizienz (nicht-akuter Beginn) wird in der Leitlinie ein neuer diagnostischer Algorithmus vorgestellt.
Prävention Nach den Ergebnissen der EMPA-REG-OUTCOME-Studie wird Empagliflozin zur Senkung der Mortalität bei Patienten mit Diabetes mellitus Typ 2 empfohlen.
Therapie Der Angiotensinrezeptor-Neprilysin-Inhibitor (ARNI) Sacubitril/Valsartan erhält eine IB-Empfehlung für Patienten, die mit einer linksventrikulären Ejektionsfraktion (LVEF) < 40 % trotz der Gabe von ACE-Hemmer, Betablocker und Mineralokortikoid-Rezeptorantagonist weiterhin symptomatisch sind.
Komorbiditäten Für Typ-2-Diabetes, Eisenmangel, Asthma bronchiale und adaptive Servoventilation wurden Änderungen der Empfehlung im Vergleich zur vorherigen Leitlinie vorgenommen.
Akute Herzinsuffizienz Die neuen ESC-Leitlinien betonen die Wichtigkeit der klinischen Evaluation des Patienten mit der Erhebung des Perfusions- und Stauungszustandes zur Ableitung therapeutischer Maßnahmen.
4.4.11 Product Subclass 11: Silyllithium and Related Silyl Alkali Metal Reagents
Authors: Kleeberg C. 
Published: August 2017

AbstractThis chapter is a revision of the earlier Science of Synthesis contribution describing methods for the synthesis of silyllithium reagents and related compounds of the heavier alkali metals. Various synthetic routes to silyl alkali metal reagents are presented, employing different reaction types including reductive or nucleophilic cleavage of disilanes, reductive metalation of silyl halides, and cleavage of Si—H bonds.
34.2.2 Fluorocyclopropanes (Update 2017)
Authors: Jubault P. , Poisson T. , Pannecoucke X. 
Published: August 2017

AbstractThis chapter is an update to the earlier Science of Synthesis contribution (Section 34.2) describing methods for the synthesis of fluorocyclopropanes. The most important breakthrough described in this update is the development of asymmetric syntheses of fluorocyclopropanes based on various approaches, such as the use of chiral fluorinated scaffolds or the development of catalytic enantioselective sequences. This review focuses on the contributions published between 2005 and 2016.
34.10.5 β-Fluoroamines (Update 2017)
Authors: Hunter L. 
Published: August 2017

AbstractThis chapter is an update to the earlier Science of Synthesis contribution (Section 34.10) describing methods for the synthesis of β-fluoroamines. This topic has continued to attract signficant attention from the synthetic community, largely due to the medicinal importance of this class of compounds. A wide variety of new methods have been developed, and this review focuses on examples that were published between 2005 and 2015.
34.1.1.8 Synthesis of Fluoroalkanes by Substitution of Hydrogen (Update 2017)
Authors: Rueda-Becerril M. , Sammis G. M. 
Published: August 2017

AbstractThis chapter is an update to the earlier Science of Synthesis contribution (Section 34.1.1) describing methods for the synthesis of fluoroalkanes by substitution of hydrogen. The increasing importance of fluorine-containing molecules in the health, pharmaceutical, and agrochemical sectors has resulted in the rapid development of more-selective, more-controlled, and safer methods for the insertion of a fluorine atom into structurally diverse molecules. Herein, the most synthetically useful methods reported from 2006 until mid-2016 to achieve such transformations are described.