bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the Cross‐Sectional Area of Longus Colli Muscle Between Patients With Cervical Radicular Pain and Healthy Controls
Authors: Noormohammadpour Pardis , Dehghani‐Firouzabadi Azime , Mansournia Mohammad Ali , Mohseni‐Bandpei Mohammad Ali , Moghaddam Navid , Miri Mojtaba , Kordi Ramin 
Published: June 2016

AbstractBackgroundPrevious studies have shown atrophy of paravertebral lumbar muscles in patients with lumbar radicular pain and have proposed rehabilitative approaches based on these findings. However, changes in cervical paravertebral muscles in patients with cervical radicular pain are still unknown.ObjectiveThe aim of this study was to compare the cross‐sectional area (CSA) of the longus colli muscle (LCM) in patients with cervical radicular pain and healthy controls via ultrasound measurement.Study DesignCase‐control study.SettingOutpatients who came for treatment to the neurosurgery clinic.ParticipantsA total of 20 patients with more than 4 weeks of cervical radicular pain and 20 healthy matched (for body mass index, age, and gender) control subjects.InterventionsUltrasound measurements.Main Outcome MeasuresThe CSA of the LCM at the level of C5‐C6 was measured by ultrasound with the subject in supine position. Also, Neck Disability Index (NDI), and visual analogue scale (VAS) scores were reported by patients. An independent‐sample t test was used for investigation of differences in CSA and other variables in both groups.ResultsA total of 20 patients with cervical radicular pain with a mean age of 42.4 years (standard deviation [SD] = 7 years) and 20 healthy matched controls with mean age of 40.7 years (SD = 7 years) participated in the study. Patients with cervical radicular pain showed smaller CSA of the LCM bilaterally compared with controls (mean difference: 0.37 [SD = 0.15]; P < .001). In the patient group, there were no significant differences between the CSA of the LCM in the involved and noninvolved sides. No correlations between the CSA of the LCM and VAS, Neck Disability Index, symptom duration, gender, BMI, and age of the patients were found.ConclusionsThis is the first study to show via ultrasound assessment that patients with cervical radicular pain had smaller bilateral CSA of the LCM in comparison with healthy controls. It is also not clear whether atrophy of the LCM in patients with cervical radicular pain is a consequence or a cause of the pain. Reduction in the stability of the neck due to atrophy of the LCM could make the cervical spine region susceptible to more injuries, which might be prevented by functional and strengthening exercises.Level of EvidenceIII
The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study
Authors: Ong Yi Lin , Quah Phaik Ling , Tint Mya Thway , Aris Izzuddin M. , Chen Ling Wei , van Dam Rob M. , Heppe Denise , Saw Seang-Mei , Godfrey Keith M. , Gluckman Peter D. , Chong Yap Seng , Yap Fabian , Lee Yung Seng , Foong-Fong Chong Mary 
Published: June 2016

AbstractMaternal vitamin D status during pregnancy has been associated with infant birth and postnatal growth outcomes, but reported findings have been inconsistent, especially in relation to postnatal growth and adiposity outcomes. In a mother–offspring cohort in Singapore, maternal plasma vitamin D was measured between 26 and 28 weeks of gestation, and anthropometric measurements were obtained from singleton offspring during the first 2 years of life with 3-month follow-up intervals to examine birth, growth and adiposity outcomes. Associations were analysed using multivariable linear regression. Of a total of 910 mothers, 13·2 % were vitamin D deficient (<50 nmol/l) and 26·5 % were insufficient (50–75 nmol/l). After adjustment for potential confounders and multiple testing, no statistically significant associations were observed between maternal vitamin D status and any of the birth outcomes – small for gestational age (OR 1·00; 95 % CI 0·56, 1·79) and pre-term birth (OR 1·16; 95 % CI 0·64, 2·11) – growth outcomes – weight-for-age z-scores, length-for-age z-scores, circumferences of the head, abdomen and mid-arm at birth or postnatally – and adiposity outcomes – BMI, and skinfold thickness (triceps, biceps and subscapular) at birth or postnatally. Maternal vitamin D status in pregnancy did not influence infant birth outcomes, postnatal growth and adiposity outcomes in this cohort, perhaps due to the low prevalence (1·6 % of the cohort) of severe maternal vitamin D deficiency (defined as of <30·0 nmol/l) in our population.
U–Pb geochronology of bentonites from the Upper Cretaceous Kanguk Formation, Sverdrup Basin, Arctic Canada: constraints on sedimentation rates, biostratigraphic correlations and the late magmatic history of the High Arctic Large Igneous Province
Authors: DAVIS WILLIAM J. , SCHRÖDER-ADAMS CLAUDIA J. , GALLOWAY JENNIFER M. , HERRLE JENS O. , PUGH ADAM T. 
Published: June 2016

AbstractU–Pb ages of zircon from bentonites within the upper Cretaceous Bastion Ridge and Kanguk formations, Sverdrup Basin, provide constraints on sedimentation rates, biostratigraphic correlations, timing of Oceanic Anoxic Event 2 (OAE2) in the High Arctic, and the late magmatic history of the High Arctic Large Igneous Province (HALIP). A late Cenomanian to early Turonian age for the base of the Kanguk Formation is confirmed that supports correlations of the global OAE2 in the High Arctic. Sedimentation rates varied from 19 m Ma−1between 93 and 91 Ma to 26 m Ma−1between 91 and 83 Ma at Axel Heiberg Island. At Ellef Ringnes Island, the lower Kanguk Formation records high rates of ~70 m Ma−1between 94 and 93 Ma, which decrease to rates comparable to those of the upper Axel Heiberg section. Differences in sedimentation rates may reflect differences in setting prior to the major transgression in the latest Cenomanian to early Turonian. The timing of Arctic occurrences of theScaphites nigricollensisandScaphites depressusammonite zones is shown to be broadly comparable to that of lower-latitude occurrences within the Western Interior Seaway. An eruption frequency of 0.5–2.5 Ma characterizes the late alkaline phase of HALIP magmatism. Volcanic bed thicknesses of 10–50 cm suggest ash transport distances of less than 1000 km. Long-lived volcanic centres, in the area of the Alpha Ridge, northern Ellesmere Island or northern Greenland, were the likely source of volcanic ash over a period of 10–15 Ma.
Perceptions of the Antarctic wilderness: views from emerging adults in Spain and the United States
Authors: Peden John , Tin Tina , Pertierra Luis R. , Tejedo Pablo , Benayas Javier 
Published: June 2016

ABSTRACTThe preambles of the 1959 Antarctic Treaty and the 1991 Protocol on Environmental Protection to the Antarctic state that Antarctica is to be managed in the interest of all mankind. However, key phrases such as ‘interest of all mankind’ and ‘wilderness and aesthetic values’ are subject to interpretation. The objective of this study is to gain a better understanding of public perceptions of the Antarctic wilderness, proceeding from the assumption that public views should be incorporated into the consultative parties’ decision making process. The study expands on previous research by exploring whether perceptions of the Antarctic environment varied between students at two comparably sized public universities in Spain and the United States. Four hundred undergraduate students were asked about their values, beliefs and attitudes with respect to environmental management practices in Antarctica. After controlling for course type, responses showed little variation based on nationality. A large proportion of students valued Antarctica as a science laboratory for the benefit of mankind, as one of the world's last great wildernesses, and an important component of the climate system. Students did not support an increase in the number of people going to Antarctica, and favoured limitations on infrastructure development.
The whys and hows of a cooperative mechanism for the Arctic marine environment
Authors: Eichbaum William M. 
Published: June 2016

ABSTRACTArctic ministers agreed at the latest 2015 Arctic Council ministerial meeting in Iqaluit to establish a ‘Task Force to assess future needs for a regional seas program or other mechanism, as appropriate, for increased cooperation in Arctic marine areas.’ Involving the Arctic Council in increased coordination of national marine management measures, and in drawing on experts from international organisations or treaty bodies to address related questions, is consistent with the longstanding advisory role of the Arctic Council. It also builds prudently on the council's emerging role as convener to accomplish discrete tasks critical to the health of the Arctic environment and the wellbeing of Arctic peoples. In order to strengthen Arctic marine cooperation and governance, the Arctic Council should adopt some instrument or arrangement through which it can more effectively coordinate among national management efforts affecting the Arctic marine environment and increase the effectiveness of the interplay with global governance mechanisms. The purpose of this commentary is to present World Wide Fund for Nature (WWF) perspectives on two important dimensions of this proposal. First, the commentary is to review the arguments as to why a strong regional seas program for the Arctic is required. Second, it is to address a series of questions that arise in considering the design of a framework mechanism necessary to create the program. The paper will provide WWF's views with regards to the mandate and scope of a future cooperative mechanism, its relationship to the Arctic Council and membership, and its legal form.
Childhood dietary patterns and cardiovascular risk factors in adolescence: results from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
Authors: Bull Caroline J , Northstone Kate 
Published: June 2016

AbstractObjectiveTo investigate the prospective associations between dietary patterns in childhood and CVD risk in adolescence.DesignProspective cohort study. Exposures were dietary patterns at age 7, 10 and 13 years derived by cluster analysis. Outcomes were physiological and biochemical cardiovascular risk markers.SettingAvon Longitudinal Study of Parents and Children (ALSPAC), UK.SubjectsChildren (n2311, 44.1 % male) with complete data available.ResultsAfter adjustment for known confounders, we observed an association between being in the ‘Processed’ and ‘Packed lunch’ dietary pattern clusters at age 7 and BMI at age 17. Compared with the ‘healthy’ cluster, the OR (95 % CI) for being in the top 10 % for BMI was 1·60 (1·01, 2·55;P=0·05) for the ‘Processed’ cluster and 1·96 (1·22, 3·13;P=0·005) for the ‘Packed lunch’ cluster. However, no association was observed between BMI and dietary patterns at age 10 and 13. Longitudinal analyses showed that being in either the ‘Processed’ or ‘Packed lunch’ cluster at age 7 was associated with increased risk of being in the top 10 % for BMI regardless of subsequent cluster membership. No associations between other cardiovascular risk measures and dietary patterns were robust to adjustment for confounders.ConclusionsWe did not find any consistent evidence to support an association between dietary patterns in childhood and cardiovascular risk factors in adolescence, with the exception of BMI and dietary pattern at age 7 only. However, the importance of dietary intake in childhood upon health later in life requires further investigation and we would encourage the adoption of a healthy diet as early in life as possible.
The associations of vitamin D status and dietary calcium with the metabolic syndrome: an analysis of the Victorian Health Monitor survey
Authors: Pannu Poonam K , Zhao Yun , Soares Mario J , Piers Leonard S , Ansari Zahid 
Published: June 2016

AbstractObjectiveTo examine the associations between serum 25-hydroxyvitamin D (25(OH)D), dietary Ca intake and presence of the metabolic syndrome (MetS).DesignA stratified cluster sample of a population aged 18–75 years from the Victorian Health Monitor survey.SettingNon-institutionalized adults living in private dwellings in Victoria, Australia.SubjectsAdults (n 3404) with complete data and without type 1 or type 2 diabetes.ResultsAdjusted for sociodemographic factors, physical characteristics and dietary covariates including Ca intake, every 10 nmol/l increase in serum 25(OH)D was significantly associated with decreased odds of MetS (adjusted odds ratio (AOR)=0·85, 95 % CI 0·80, 0·89; P<0·001). Relative to the low 25(OH)D tertile (median 33 nmol/l), there was a progressive decrease in odds of MetS that reached significance with the high 25(OH)D tertile (median 77 nmol/l; AOR=0·35, 95 % CI 0·26, 0·48; P<0·001). Every 500 mg/d increase in Ca intake adjusted for 25(OH)D did not reduce odds of MetS (AOR=0·81, 95 % CI 0·66, 1·06; P=0·141) but approached significance if unadjusted for 25(OH)D in the final model (AOR=0·81, 95 % CI 0·64, 1·02; P=0·073). No significant effect was obtained for tertiles of Ca intake. However, Ca and vitamin D tertile combinations suggested a beneficial effect of high Ca (median 1233 mg/d) only at low and medium 25(OH)D. The high 25(OH)D tertile was associated with significantly decreased odds of MetS regardless of Ca intake.ConclusionsA high vitamin D status significantly reduced the odds of MetS. A high Ca intake may have a similar favourable outcome but only at lower circulating concentrations of 25(OH)D.
Life Satisfaction and Value Congruence
Authors: Khaptsova Alyona , Schwartz Shalom H. 
Published: June 2016

Abstract. Congruence between own and reference group values promotes life satisfaction. Does this effect extend to value congruence with others with whom one does not interact but who share socio-demographic characteristics? We constructed 36 socio-demographic categories in a representative Russian national sample (N = 961). Correlations of individuals’ values with the mean value of their category indexed value congruence. Both a meta-analysis across the constructed groups and an individual level regression analysis confirmed a positive value congruence – life satisfaction effect. This effect held even when controlling for age, gender, education, religiosity, region, religion, and the 19 values on which the congruence score was based. Self-direction-action values moderated the effect: it was stronger the less important independence of action was to individuals.
Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4
Authors: Xiao J , Pan Y , Li X H , Yang X Y , Feng Y L , Tan H H , Jiang L , Feng J , Yu X Y 
Published: June 2016

AbstractCardiac progenitor cells derived from adult heart have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are known to mediate cell–cell communication by transporting cell-derived proteins and nucleic acids, including various microRNAs (miRNAs). Here we investigated the cardiac progenitor cell (CPC)-derived exosomal miRNAs on protecting myocardium under oxidative stress. Sca1+CPCs-derived exosomes were purified from conditional medium, and identified by nanoparticle trafficking analysis (NTA), transmission electron microscopy and western blotting using CD63, CD9 and Alix as markers. Exosomes production was measured by NTA, the result showed that oxidative stress-induced CPCs secrete more exosomes compared with normal condition. Although six apoptosis-related miRNAs could be detected in two different treatment-derived exosomes, only miR-21 was significantly upregulated in oxidative stress-induced exosomes compared with normal exosomes. The same oxidative stress could cause low miR-21 and high cleaved caspase-3 expression in H9C2 cardiac cells. But the cleaved caspase-3 was significantly decreased when miR-21 was overexpressed by transfecting miR-21 mimic. Furthermore, miR-21 mimic or inhibitor transfection and luciferase activity assay confirmed that programmed cell death 4 (PDCD4) was a target gene of miR-21, and miR-21/PDCD4 axis has an important role in anti-apoptotic effect of H9C2 cell. Western blotting and Annexin V/PI results demonstrated that exosomes pre-treated H9C2 exhibited increased miR-21 whereas decreased PDCD4, and had more resistant potential to the apoptosis induced by the oxidative stress, compared with non-treated cells. These findings revealed that CPC-derived exosomal miR-21 had an inhibiting role in the apoptosis pathway through downregulating PDCD4. Restored miR-21/PDCD4 pathway using CPC-derived exosomes could protect myocardial cells against oxidative stress-related apoptosis. Therefore, exosomes could be used as a new therapeutic vehicle for ischemic cardiac disease.
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
Authors: Shostak Anton , Ruppert Bianca , Ha Nati , Bruns Philipp , Toprak Umut H. ,   ICGC MMML-Seq Project, Lawerenz Chris , Lichter Peter , Radlwimmer Bernhard , Eils Jürgen , Brors Benedikt , Radomski Sylwester , Scholz Ingrid , Richter Gesine , Siebert Reiner , Wagner Susanne , Haake Andrea , Richter Julia , Aukema Sietse , Ammerpohl Ole , Lopez Christina , Nagel Inga , Vater Inga , Wagner Rabea , Borst Christoph , Haas Siegfried , Rohde Marius , Burkhardt Birgit , Lisfeld Jasmin , Claviez Alexander , Dreyling Martin , Eberth Sonja , Trümper Lorenz , Kube Dieter , Stadler Christina , Einsele Hermann , Frickhofen Norbert , Hansmann Martin-Leo , Karsch Dennis , Kneba Michael , Mantovani-Löffler Luisa , Staib Peter , Stilgenbauer Stephan , Ott German , Küppers Ralf , Weniger Marc , Hummel Michael , Lenze Dido , Szczepanowski Monika , Klapper Wolfram , Kostezka Ulrike , Möller Peter , Rosenwald Andreas , Leich Ellen , Pischimariov Jordan , Binder Vera , Borkhardt Arndt , Hezaveh Kebria , Hoell Jessica , Rosenstiel Philip , Schilhabel Markus , Schreiber Stefan , Bernhart Stephan H. , Doose Gero , Hoffmann Steve , Kretzmer Helene , Langenberger David , Binder Hans , Hopp Lydia , Kreuz Markus , Loeffler Markus , Rosolowski Maciej , Korbel Jan , Sungalee Stefanie , Stadler Peter F. , Zenz Thorsten , Eils Roland , Schlesner Matthias , Diernfellner Axel , Brunner Michael 
Published: June 2016

AbstractThe circadian clock and the cell cycle are major cellular systems that organize global physiology in temporal fashion. It seems conceivable that the potentially conflicting programs are coordinated. We show here that overexpression of MYC in U2OS cells attenuates the clock and conversely promotes cell proliferation while downregulation of MYC strengthens the clock and reduces proliferation. Inhibition of the circadian clock is crucially dependent on the formation of repressive complexes of MYC with MIZ1 and subsequent downregulation of the core clock genes BMAL1 (ARNTL), CLOCK and NPAS2. We show furthermore that BMAL1 expression levels correlate inversely with MYC levels in 102 human lymphomas. Our data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression.
Circadian regulation of human cortical excitability
Authors: Ly Julien Q. M. , Gaggioni Giulia , Chellappa Sarah L. , Papachilleos Soterios , Brzozowski Alexandre , Borsu Chloé , Rosanova Mario , Sarasso Simone , Middleton Benita , Luxen André , Archer Simon N. , Phillips Christophe , Dijk Derk-Jan , Maquet Pierre , Massimini Marcello , Vandewalle Gilles 
Published: June 2016

AbstractProlonged wakefulness alters cortical excitability, which is essential for proper brain function and cognition. However, besides prior wakefulness, brain function and cognition are also affected by circadian rhythmicity. Whether the regulation of cognition involves a circadian impact on cortical excitability is unknown. Here, we assessed cortical excitability from scalp electroencephalography (EEG) responses to transcranial magnetic stimulation in 22 participants during 29 h of wakefulness under constant conditions. Data reveal robust circadian dynamics of cortical excitability that are strongest in those individuals with highest endocrine markers of circadian amplitude. In addition, the time course of cortical excitability correlates with changes in EEG synchronization and cognitive performance. These results demonstrate that the crucial factor for cortical excitability, and basic brain function in general, is the balance between circadian rhythmicity and sleep need, rather than sleep homoeostasis alone. These findings have implications for clinical applications such as non-invasive brain stimulation in neurorehabilitation.
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
Authors: Evrard Solene M. , Lecce Laura , Michelis Katherine C. , Nomura-Kitabayashi Aya , Pandey Gaurav , Purushothaman K-Raman , d’Escamard Valentina , Li Jennifer R. , Hadri Lahouaria , Fujitani Kenji , Moreno Pedro R. , Benard Ludovic , Rimmele Pauline , Cohain Ariella , Mecham Brigham , Randolph Gwendalyn J. , Nabel Elizabeth G. , Hajjar Roger , Fuster Valentin , Boehm Manfred , Kovacic Jason C. 
Published: June 2016

AbstractEndothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells including fibroblasts are prominent in atherosclerosis, with key functions including regulation of: inflammation, matrix and collagen production, and plaque structural integrity. However, little is known about the origins of atherosclerosis-associated fibroblasts. Here we show using endothelial-specific lineage-tracking that EndMT-derived fibroblast-like cells are common in atherosclerotic lesions, with EndMT-derived cells expressing a range of fibroblast-specific markers. In vitro modelling confirms that EndMT is driven by TGF-β signalling, oxidative stress and hypoxia; all hallmarks of atherosclerosis. ‘Transitioning’ cells are readily detected in human plaques co-expressing endothelial and fibroblast/mesenchymal proteins, indicative of EndMT. The extent of EndMT correlates with an unstable plaque phenotype, which appears driven by altered collagen-MMP production in EndMT-derived cells. We conclude that EndMT contributes to atherosclerotic patho-biology and is associated with complex plaques that may be related to clinical events.
A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
Authors: Matsuki Takahiro , Yahagi Kana , Mori Hiroshi , Matsumoto Hoshitaka , Hara Taeko , Tajima Saya , Ogawa Eishin , Kodama Hiroko , Yamamoto Kazuya , Yamada Takuji , Matsumoto Satoshi , Kurokawa Ken 
Published: June 2016

AbstractRecent studies have demonstrated that gut microbiota development influences infants’ health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affect infant health. Genome analysis of infants’ bifidobacteria reveals an ABC transporter as a key genetic factor for FL utilization. Thus, the ability of bifidobacteria to utilize FL and the presence of FL in breast milk may affect the development of the gut microbiota in infants, and might ultimately have therapeutic implications.