bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent therapeutic community treatment – an Australian perspective
Authors: Northam Jaimie Chloe , Magor-Blatch Lynne Elizabeth 
Published: November 2016

Purpose
The purpose of this paper is to provide an overview of the adolescent therapeutic community (ATC) literature – drawing on studies primarily from the USA with consideration made to the Australian context.

Design/methodology/approach
A review of the efficacy research for ATCs is considered, and the characteristics of Australians accessing ATC treatment are discussed in the context of developmental needs.

Findings
Similarities are found in what precipitates and perpetuates adolescent substance use in the USA and Australia, and therefore, what appears to facilitate effective treatment utilising the therapeutic community model.

Originality/value
The paper provides a valuable perspective for Australian services, and explores the application of the ATC model within the Australian treatment context.
Understanding personal change through storytelling in a therapeutic community
Authors: Clarke Jenelle Marie 
Published: November 2016

Purpose
The purpose of this paper is to explore the potential for personal and community transformation through storytelling within a therapeutic community (TC) through the analysis of one narrative case study.

Design/methodology/approach
The paper uses a narrative research design to describe and theorise the individual narrative of a TC client member, “Emily”, who self-identified areas of therapeutic change. Emily’s story is a single case of personal and community transformation. Analysis focussed on story of her weight loss to understand her changing role to herself and the community.

Findings
Emily’s story reveals the social complexities underpinning individual transformations within a community context. This complexity is particularly evident as Emily experienced visible weight loss but identified that the meaningful change is her changed relationship with herself and others. Using theories on symbolic interactionism, analysis of Emily’s narrative indicates the TC played a role in facilitating personal change and that through sharing her story with the wider TC, the community shifted its perspective on food and weight loss.

Originality/value
The paper expands the discussion on how storytelling practices within a TC contribute to therapeutic change. It is argued that community relationships play a key role in facilitating a changed relationship with self and others, and that stories themselves play an active role in shaping community meanings.
Faculty use of a learning object repository in higher education
Authors: Xu Hong 
Published: November 2016

Purpose
The purpose of this study was to learn faculty’s usage behavior in learning object repositories (LORs).

Design/methodology/approach
This paper is a case study. Research subjects were the faculty users from an LOR: Wisconsin Online Resource Center. The study used a survey instrument to collect data from 92 respondents, and data were analyzed by descriptive statistics and a Fisher exact test.

Findings
The study found four important channels by which the faculty learn about a LOR, six ways in which the faculty often use a LOR and an important factor affecting the faculty visiting a LOR.

Research limitations/implications
Research subjects were from one LOR and non-probability sampling was used; thus, the generalization of findings may be limited.

Practical implications
This study implemented advancing of the service and design of LORs from the perspectives of promotion, content development, connection to learning management systems and technology assistant.

Social implications
The findings and results may be applied in practice to draw more faculty users toward learning object repository.

Originality/value
The results and findings of the study contribute to understanding the faculty’s needs for and usage patterns of using LORs, and provide foundations for designing strategies to increase faculty use of LORs.
Effects of workplace spirituality and trust mediated by perceived risk towards knowledge sharing behaviour
Authors: Rahman Muhammad Sabbir , Mat Daud Nuraihan , Hassan Hasliza , Osmangani Aahad M. 
Published: November 2016

PurposeThis research paper aims to provide an empirical examination to explain the relationship between trust, workplace spirituality, perceived risk and knowledge sharing behaviour among the non-academic staff of private higher learning institutions.Design/methodology/approachA quantitative methodology was adopted to examine the proposed relationship between trust, workplace spirituality, perceived risk and knowledge sharing behaviour. The study used survey data from 240 non-academic staff of private higher learning institutions in Malaysia. This research applied confirmatory factor analysis and structural equation modelling to test the stated hypotheses of the proposed conceptual framework.FindingsThe empirical findings indicate that workplace spirituality has a significant positive influence on knowledge sharing behaviour, whereas trust is found to have a positive effect, mediated by perceived risk, on the knowledge sharing behaviour among the non-academic staff of private higher learning institutions.Research limitations/implicationsThe study was limited to private higher learning institutions in Malaysia, and used a cross-sectional research design. Further investigations into the moderating effect of socio-demographic variables are necessary.Practical implicationsThe results of this survey provide constructive information towards understanding the extent of knowledge sharing predictors at the individual and non-academic staff levels in the context of private higher learning institutions in Malaysia. Thus, this empirical study serves as a baseline research for this unexplored scope as it provides new information in this field.Originality/valuePrevious studies have not tested the function of trust and workplace spirituality from the perspective of non-academic staff employed in private higher learning institutions.
Knowledge sharing among healthcare professionals in Ghana
Authors: Assem Patrick Boateng , Pabbi Kwaku Agyepong 
Published: November 2016

Purpose
Knowledge management is very useful to the most departments and sectors of the economy, and the healthcare sector is no exception. Thus, this paper aims to explore how healthcare professionals share knowledge in the Ghanaian healthcare sector. It also ascertains challenges faced by healthcare professionals in Ghana with regards to knowledge sharing.

Design/methodology/approach
The study used a case study research design. Data were collected from some healthcare professions working in the Ejisu-Juaben Municipality in Ghana using face-to-face interview. Data were analysed using thematic analysis technique.

Findings
The results show that the healthcare facilities studied do not have any formal knowledge management systems, and therefore healthcare professionals rely on informal conversations and seminars to share knowledge. Again, it was found that lack of trust, lack of technological facilities, lack of organizational policy regarding, fear of getting extra task or responsibility, network failure (both mobile phone and internet) and culture are some of the challenge healthcare professionals face in sharing knowledge.

Originality/value
This study contributes to the knowledge sharing literature especially in the healthcare sector in Ghana, as limited studies have been conducted in this area.
Towards a framework for strategic knowledge management practice
Authors: Huang Fang , Gardner Scott , Moayer Sanaz 
Published: November 2016

Purpose
This paper aims to address the limitations of current knowledge management (KM) models by presenting a strategic knowledge management (SKM) framework based on a unique configuration of literature concerned with optimising learning and knowledge creation at the interface between human (soft) and information and communication technology (hard) networks.

Design/methodology/approach
This paper revisits the key tenets and most frequently cited models in the existing literature, summarises their common elements, clarifies the interrelationships between the hard and soft KM processes and practices and systemically incorporates these previously separate and independent elements into a new integrated conceptual framework. Then, it identifies key organisational factors which could facilitate this integration and leverage the value generated from different systems embedded in this model.

Findings
The paper highlights the key elements and applications of a new SKM conceptual model for actively and purposefully integrating explicit and tacit knowledge embedded within organisation systems and broader social and business intelligence networks.

Practical implications
The application of the thinking, organising principles and management practices derived from the SKM framework with its unique characteristics that are hard to substitute or imitate may support improvement and/or innovation of processes, products, services and brands contributing to sustainable competitive advantage of the firm.

Originality/value
While both hard and soft KM systems have been individually identified by previous studies as integral to KM, the research is amongst the first attempts to explore how to integrate both systems within a strategic KM framework with supporting organisational design principles for creating firm competitive advantage.
Age‐related common miRNA polymorphism associated with severe toxicity in lung cancer patients treated with platinum‐based chemotherapy
Authors: Fang Chao , Li Xiang‐Ping , Gong Wei‐Jing , Wu Na‐Yiyuan , Tang Jie , Yin Ji‐Ye , Li Xi , Zhang Wei , Zhou Hong‐Hao , Liu Zhao‐Qian 
Published: November 2016

SummaryPlatinum‐based chemotherapy toxicity severely impedes successful treatment in lung cancer patients. MicroRNAs (miRs) have a significant impact on the occurrence and survival rate of lung cancer. The purpose of this study was to investigate the association between common miRNA variants and platinum‐based chemotherapy toxicity in lung cancer patients. A total of eight functional single nucleotide polymorphisms (SNPs) of miRNA were genotyped in 408 lung cancer patients by MALDI‐TOF mass spectrometry. All the patients were histologically confirmed as lung cancer, and were treated with platinum‐based chemotherapy for at least two cycles. It was found that the polymorphism rs2042553 of miR‐5197 had a significant association with overall severe toxicity in both additive (P=.031, odds ratio [OR]=1.41, 95% confidence interval [CI] 1.03‐1.93) and dominant (P=.009, OR=1.80, 95% CI 1.16‐2.80) models. MiR‐605 rs2043556 was significantly related to severe hepatotoxicity in dominant model (P=.022, OR=2.51, 95% CI 1.12‐4.14). In addition, rs2910164 of miR‐146a had marginal statistical effect on severe hepatotoxicity in additive model (P=.054). The subgroup analyses showed that miR‐27a rs895819 was related to gastrointestinal toxicity in age >56 years old, smoking and non‐smoking patients. Taken together, our results revealed that polymorphisms of miR‐5197, miR‐605, miR‐146a, and miR‐27a contributed to the chemotherapy toxicity of lung cancer, which may serve as a predictive tool for toxicity evaluation of platinum‐based chemotherapy in lung cancer patients.
Piperine—The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations
Authors: Gorgani Leila , Mohammadi Maedeh , Najafpour Ghasem D. , Nikzad Maryam 
Published: November 2016

AbstractPiperine is the major bio‐active component of pepper, which imparts pungency and biting taste to it. This naturally occurring alkaloid has numerous demonstrated health effects and beneficial therapeutic properties; nevertheless, its biological applications are limited due to its poor solubility in aqueous environments. This emphasizes an implementation of advanced extraction approaches which could enhance the extraction yield of piperine from pepper and also the development of new formulations containing piperine to improve its in vivo bioavailability. This paper presents a review on the therapeutic and medicinal effects of piperine, its isolation from pepper fruit and the development of new formulations for its medicinal (pharmaceutical) applications. A thorough review on conventional and advanced separation techniques for the extraction of piperine from pepper is presented and an outline of the most significant conditions to improve the extraction yield is provided and discussed. Different methods used to measure and quantify the isolated piperine are also reviewed. An overview of biotechnological advancements for nanoparticle formulations of piperine or its incorporation in lipid formulations, which could enhance its bioavailability, is also presented.
Passive Drip Stain Formation Dynamics of Blood onto Hard Surfaces and Comparison with Simple Fluids for Blood Substitute Development and Assessment,
Authors: Stotesbury Theresa , Taylor Michael C. , Jermy Mark C. 
Published: November 2016

AbstractThe spreading dynamics of blood dripping onto hard surfaces is compared to two spreading models. Samples of human blood, porcine blood, and Millipore® water were dripped onto cardboard, foamcore, and glass surfaces in low velocity passive drip simulations. Final stain diameter, the total number of spines and scallops, and angle of impact were measured and analyzed. Spreading is best predicted by applying the concept of effective viscosity to the Scheller and Bousfield (R2 = 0.91) and Roisman (R2 = 0.89) spreading models. In the tested conditions, blood spreads with Newtonian tendencies; however, has quantifiable differences in stain appearance to Newtonian fluids like water. This is encouraging for the development of water‐based fluids as synthetic blood substitutes (SBSs). The work presents an assessment platform to quantify and score the performance of simple water‐based fluids using final stain diameter (6 points) and number of spines and scallops (6 points) at six dripping heights between 20 and 120 cm. The angle of impact of a stain alone is not a sensitive measure of SBS performance, but stain formation scores the SBS's performance with another 1 point. Together these features generate a quantitative relative ranking system, of a maximum possible 13 points, that can be used to support the use of a particular fluid for the creation of a drip stain. The performance of twenty simple fluids in the simulated dripping assessment test is described.
Lessons Learned from Autopsying an Unidentified Body with Iodine‐125 Seeds Implanted for Prostate Brachytherapy
Authors: Idota Nozomi , Nakamura Mami , Masui Koji , Kakiuchi Yasuhiro , Yamada Kei , Ikegaya Hiroshi 
Published: November 2016

AbstractWe report here lessons learned from an autopsy case involving radioactive materials. We performed an autopsy of an unidentified mummified man with no available medical history whom from imaging findings we suspected had received radioactive seed implants for prostate brachytherapy. We returned the excised prostate and seeds to the body. A few days later, the body was identified by DNA matching and cremated. According to the man's medical record, he had undergone iodine‐125 seeds implantation for prostate cancer 11 months earlier. We should have removed the radioactive seeds from the body to prevent radiation exposure to the bereaved family and/or environmental pollution due to cremation. Surprisingly, one seed was found in the stored prostate specimen. Forensic experts should be cognizant of the risk of both radiation exposure in the autopsy room and environmental pollution. We must remain abreast of the latest advances in medicine.
Retrospective review of Prothrombinex use by SAAS MedSTAR
Authors: Fischer Roy , Brettig Simon , Pearce Andrew 
Published: November 2016

AbstractObjectiveThe aim of this study was to review and describe the use of Prothrombinex by a physician‐led retrieval service based remote from a hospital blood bank.MethodsThis is a retrospective observational study. Patients to whom Prothrombinex was administered by the retrieval team were identified from the retrieval service patient database. The paper case cards of the identified patients were then manually reviewed and the data matched to patients in the state‐wide electronic laboratory record.ResultsBetween 1 January 2010 and 30 November 2013 38 cases were identified. For 28 the indication was warfarinisation associated with life‐threatening bleeding (most commonly intracranial or gastrointestinal tract). In the remaining 10 cases, Prothrombinex was used to treat coagulopathy associated with liver disease or massive haemorrhage. The median time saved by the retrieval team administering PTX‐VF, rather than waiting to the receiving centre, was 120 min (interquartile range: 85–195 min). The median dose of PTX‐VF administered was 23.25 IU/kg (interquartile range: 20–33 IU/kg). Paired international normalised ratios (INRs) were available for 33 of the 38 patients. In the warfarin group, all patients had an improvement in their INR and 21 of 25 had correction of their INR. In the non‐warfarin group, the effect on INR was more variable.ConclusionProthrombinex is a clinically useful product that can be relatively easily stored and used by retrieval services, even if they are based in isolation from a hospital blood bank. More research is required to look at the utility of Prothrombinex for non‐warfarin‐related bleeding in the pre‐hospital and retrieval environment.
The role of microbiota in compensatory growth of protein‐restricted rats
Authors: Zhu Yizhi , Niu Qingyan , Shi Chao , Wang Jing , Zhu Weiyun 
Published: November 2016

SummaryCompensatory growth is a physiological phenomenon found in both humans and animals. However, the underlying mechanisms are unclear. In this study, for the first time, we investigated the role of microbiota in compensatory growth induced by protein restriction using a rat model. Weaned Sprague‐Dawley rats were fed a low protein diet (L group), a normal protein diet (N group) and a low protein diet for 2 weeks followed by a normal protein diet (LN group). The results showed that in contrast with the inhibited growth of rats in the L group, compensatory growth was observed in the LN group. Meanwhile, rats in the LN group had increased concentrations of total short chain fatty acids, particularly butyrate, and an altered bacterial composition with modified abundances of Peptostreptococcaceae, Bifidobacteriaceae, Porphyromonadaceae and Prevotellaceae in the colonic content. Furthermore, gene expression analysis indicated that the rats that experienced compensatory growth had improved barrier function and innate immune function in the colon. Our data revealed the importance of colonic microbiota in achieving compensatory growth.
The Spectatorial Gaze: Viewer–Voyeur Dynamics in Book Illustrations of Diderot's La Religieuse
Authors: Pierse Síofra 
Published: November 2016

AbstractThis article analyses the manner in which Diderot's novel La Religieuse (1796) has been interpreted in book illustration. There has long been an assumption that Jean‐François Le Barbier was the first illustrator of La Religieuse, whereas this article posits that a number of significant artists preceded him: an anonymous artist (1796), the designer P. J. Challiou (1797) and another unknown illustrator (1797). This analytical investigation is followed by an overview of viewer–voyeur trends in the subsequent illustration of La Religieuse, suggesting that core representation dilemmas, together with the interpretative strategies adopted, vary remarkably little across more than two centuries of reception and illustration.
The Other Pamela: Readership and the Illustrated Chapbook Abridgement
Authors: Jung Sandro 
Published: November 2016

AbstractThis article investigates questions of readership, pricing and visual literacy by relating eighteenth‐century illustrated chapbook abridgements of Samuel Richardson's Pamela (1740) to the author's 1742 edition, featuring illustrations by Hubert‐François Gravelot and Francis Hayman. It focuses on the affordability of chapbook abridgements and the straightforward readability of their illustrations, which would have been accessible to many readers. While few readers would have had access, financially, to the Gravelot–Hayman de luxe edition, Pamela chapbooks reached larger groups of readers and shaped the text's popular reception.
Visual Sterneana: Graphic Afterlives and a Sense of Infinite Mobility
Authors: Friant‐Kessler Brigitte 
Published: November 2016

AbstractThis article explores how the notion of mobility resonates with visual responses to Sterne's fiction (1996‐2016). With a specific focus on migration patterns of the Sterne/Tristram/Yorick triad, it is argued that artists have created, in a variety of media, a body of visual Sterneana characterised by embedded imaginary spaces and multiple interpretative frames through a fluctuating proximity with the text and the enduring ubiquity of eighteenth‐century images in the form of graphic afterlives. Emblematic motifs and isolated fragments, as well as circulation in cyberspace, also raise the issue of how the word and image relationship is continuously reconfigured.
Intermedial Approaches to Marivaux's La Vie de Marianne: Text, Illustration, Film
Authors: Lewis Ann 
Published: November 2016

AbstractUsing the theoretical framework of ‘intermediality’, this article examines the ways in which Marivaux's novel La Vie de Marianne (1731‐42) has been pictured through time. It explores the relationship between text and image in various illustrations and in Benoît Jacquot's film adaptation Marianne (1995), focusing on episodes involving Marianne and her benefactor M. de Climal. Not only do these transpositions suggest complex forms of reception of Marivaux's text, but in their anticipation of and engagement with other media (theatre, painting, cinema) they also provide a richly suggestive interrogation of the conditions of theatricality and of what it means to become a ‘spectacle’.
Temperature, invaders and patchy habitat interact to limit the distribution of a vulnerable freshwater fish
Authors: Boddy Nixie C. , McIntosh Angus R. 
Published: November 2016

AbstractInteracting global‐change drivers such as invasive species and climate warming are likely to have major and potentially unexpected influences on aquatic ecosystems. In river networks, modified water temperature combined with patchy physical conditions will likely cause shifts in the amount and distribution of suitable habitat, with influential invasive species further altering habitat availability. We examined how distributions of a thermally sensitive galaxiid fish native to the alpine rivers of New Zealand, Galaxias paucispondylus, were influenced by these drivers using spatially extensive presence–absence electrofishing surveys of 46 sites spread over four subcatchments. A unimodal response to water temperature and an interaction with substratum size meant G. paucispondylus were limited to streams with average summer water temperatures between 10.6 and 13.8 °C and were absent when average substratum sizes were <36 mm, regardless of temperature. In addition, non‐native trout >150 mm long excluded G. paucispondylus, but were only found in streams with average summer water temperatures <10.6 °C. These influences of trout likely strengthened the unimodal temperature response of G. paucispondylus and led to a very small G. paucispondylus realized niche. When predicted temperature increases were applied to catchment models, G. paucispondylus distributions were patchy and variable across subcatchments. Moreover, local physical characteristics of river networks were particularly important because of the non‐linear and interactive influences of temperature and substratum size on the outcome of species interactions. Therefore, substratum sizes, water temperature and a non‐native predator combined to influence the distribution of this thermally sensitive fish, illustrating how the effects of climate warming will likely be strongly context‐dependent and interactive.