bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copy-number signatures and mutational processes in ovarian carcinoma
Authors: Macintyre Geoff , Goranova Teodora E. , De Silva Dilrini , Ennis Darren , Piskorz Anna M. , Eldridge Matthew , Sie Daoud , Lewsley Liz-Anne , Hanif Aishah , Wilson Cheryl , Dowson Suzanne , Glasspool Rosalind M. , Lockley Michelle , Brockbank Elly , Montes Ana , Walther Axel , Sundar Sudha , Edmondson Richard , Hall Geoff D. , Clamp Andrew , Gourley Charlie , Hall Marcia , Fotopoulou Christina , Gabra Hani , Paul James , Supernat Anna , Millan David , Hoyle Aoisha , Bryson Gareth , Nourse Craig , Mincarelli Laura , Sanchez Luis Navarro , Ylstra Bauke , Jimenez-Linan Mercedes , Moore Luiza , Hofmann Oliver , Markowetz Florian , McNeish Iain A. , Brenton James D. 
Published: August 2017

AbstractGenomic complexity from profound copy-number aberration has prevented effective molecular stratification of ovarian and other cancers. Here we present a method for copy-number signature identification that decodes this complexity. We derived eight signatures using 117 shallow whole-genome sequenced high-grade serous ovarian cancer cases, which were validated on a further 497 cases. Mutational processes underlying the copy-number signatures were identified, including breakage-fusion-bridge cycles, homologous recombination deficiency and whole-genome duplication. We show that most tumours are heterogeneous and harbour multiple signature exposures. We also demonstrate that copy number signatures predict overall survival and changes in signature exposure observed in response to chemotherapy suggest potential treatment strategies.
MHCflurry: open-source class I MHC binding affinity prediction
Authors: O’Donnell Timothy , Rubinsteyn Alex , Bonsack Maria , Riemer Angelika , Hammerbacher Jeff 
Published: August 2017

AbstractMachine learning prediction of the interaction between major histocompatibility complex I (MHC I) proteins and their small peptide ligands is important for vaccine design and other applications in adaptive immunity. We describe and benchmark a new open-source MHC I binding prediction package, MHCflurry. The software is a collection of allele-specific binding predictors incorporating a novel neural network architecture and adhering to software development best practices. MHCflurry outperformed the standard predictors NetMHC 4.0 and NetMHCpan 3.0 on a benchmark of mass spec-identified MHC ligands and showed competitive accuracy on a benchmark of affinity measurements. The accuracy improvement was due to substantially better prediction of non-9-mer peptide ligands, which offset a narrowly lower accuracy on 9-mers. MHCflurry was on average 8.6X faster than NetMHC and 44X faster than NetMHCpan; performance is further increased when a graphics processing unit (GPU) is available. MHCflurry is freely available to use, retrain, or extend, includes Python library and command line interfaces, and may be installed using standard package managers.
A catch-bond drives stator mechanosensitivity in the Bacterial Flagellar Motor
Authors: Nord AL , Gachon E , Perez-Carrasco R , Nirody JA , Barducci A , Berry RM , Pedaci F 
Published: August 2017

AbstractThe bacterial flagellar motor (BFM) is the rotary motor which powers the swimming and swarming of many motile bacteria. The torque is provided by stator units, ion motive force powered ion channels known to assemble and disassemble dynamically in the BFM. This turnover is mechano-sensitive, with the number of engaged units dependent upon the viscous load experienced by the motor through the flagellum. However, the molecular mechanism driving BFM mechano-sensitivity is unknown. Here we directly measure the kinetics of arrival and departure of the stator units in individual wild-type motors via analysis of high-resolution recordings of motor speed, while dynamically varying the load on the motor via external magnetic torque. Obtaining the real-time stator stoichiometry before and after periods of forced motor stall, we measure both the number of active stator units at steady-state as a function of the load and the kinetic association and dissociation rates, by fitting the data to a reversible random sequential adsorption model. Our measurements indicate that BFM mechano-sensing relies on the dissociation rate of the stator units, which decreases with increasing load, while their association rate remains constant. This implies that the lifetime of an active stator unit assembled within the BFM increases when a higher force is applied to its anchoring point in the cell wall, providing strong evidence that a catch-bond mechanism can explain the mechano-sensitivity of the BFM.
Sniff invariant odor coding
Authors: Shusterman Roman , Sirotin Yevgeniy B. , Smear Matthew C. , Ahmadian Yashar , Rinberg Dmitry 
Published: August 2017

SummarySampling regulates stimulus intensity and temporal dynamics at the sense organ. Despite variations in sampling behavior, animals must make veridical perceptual judgments about external stimuli. In olfaction, odor sampling varies with respiration, which influences neural responses at the olfactory periphery. Nevertheless, rats were able to perform fine odor intensity judgments despite variations in sniff kinetics. To identify the features of neural activity supporting stable intensity perception, in awake mice we measured responses of Mitral/Tufted (MT) cells to different odors and concentrations across a range of sniff frequencies. Amplitude and latency of the MT cells’ responses vary with sniff duration. A fluid dynamics (FD) model based on odor concentration kinetics in the intranasal cavity can account for this variability. Eliminating sniff waveform dependence of MT cell responses using the FD model significantly improves concentration decoding. This suggests potential schemes for sniff waveform invariant odor concentration coding.HighlightsOdor concentration discrimination does not depend on sniff frequencyAmplitude and latency of MT cell responses vary with sniff frequencyA fluid dynamic based model accounts for sniff dependent variability in the responsesTransforming MT cell responses with this model achieves sniff invariant coding
Mobile banking services adoption in Pakistan: are there gender differences?
Authors: Glavee-Geo Richard , Shaikh Aijaz Ahmed , Karjaluoto Heikki 
Published: August 2017

Purpose
The purpose of this paper is to provide a comprehensive insight into the deciding factors affecting an individual’s intention to adopt mobile banking (m-banking) services in Pakistan.

Design/methodology/approach
A survey approach was used with a sample of 189 responses from across Pakistan. Multi-group analysis was performed in order to detect gender differences among men and women in the process of adopting m-banking.

Findings
The paper found support for the positive effect of perceived behavioral control (PBC) and attitudes (ATT) toward m-banking adoption intentions. Significant differences between men and women were found to affect subjective norms (SN) on adoption intention, even though the combined sample of men and women was insignificant. The effect of SN on m-banking adoption is stronger for women than for men. Interestingly, the paper provides contradictory findings on the role of PBC on adoption intention. The effect of PBC on m-banking adoption intention was found to be significantly stronger for men than for women.

Practical implications
The results present implications of consumer behavior and marketing communication for bank marketing. Although men and women do not differ in their ATT toward m-banking service adoption in general, the succinct nuance between men and women in terms of the influence of SN and PBC with adoption intention calls for a strategic reorientation of how men and women as consumers of m-banking services should be appropriately segmented, targeted and communicated. The formulation of marketing strategies to target potential consumers and to reinforce the usefulness of m-banking to existing consumers should not be “one size fits all.” The marketing of m-banking services to segments of men and women should be approached strategically in order to increase adoption rates in developing/emerging economies.

Originality/value
This is the first study on m-banking services adoption in Pakistan to examine the role of gender in the innovation adoption process. The differences between the two genders and the insightful results that we found in our study help shed light on the uniqueness of the context. This study is also one of the first to test a combined technology acceptance model and theory of planned behavior model in the context of m-banking adoption in a developing country using a variance-based modeling technique.
The Performance Effect of Feedback Frequency and Detail: Evidence from a Field Experiment in Customer Satisfaction
Authors: CASAS‐ARCE PABLO , LOURENÇO SOFIA M. , MARTÍNEZ‐JEREZ F. ASÍS 
Published: August 2017

ABSTRACTThis paper presents the results from a field experiment that examines the effects of nonfinancial performance feedback on the behavior of professionals working for an insurance repair company. We vary the frequency (weekly and monthly) and the level of detail of the feedback that the 800 professionals receive. Contrary to what we would expect if these professionals conformed to the model of the Bayesian decision maker, more (and more frequent) information does not always help improve performance. In fact, we find that professionals achieve the best outcomes when they receive detailed but infrequent (monthly) feedback. The treatment groups with frequent feedback, regardless of how detailed it is, perform no better than the control group (with monthly and aggregate information). The results are consistent with the information in the latest feedback report being most salient and professionals in the weekly treatments overweighting their most recent performance, hampering their ability to learn.
Relationship between alanine aminotransferase levels and type 2 diabetes mellitus in the general Chinese population
Authors: Liu Aihua , Chen Shuang , Guo Xiaofan , Li Zhao , Zheng Liqiang , Sun Yingxian 
Published: August 2017

Highlights

The present large‐scale study of rural participants aged ≥35 years in the general Chinese population showed that the prevalence of type 2 diabetes mellitus (T2DM) increased with increments in alanine aminotransferase (ALT) concentrations and that increased ALT concentrations were significantly associated with the risk of T2DM.
Concentrations of ALT >40 U/L were significantly associated with the increased prevalence of T2DM in addition to hypertriglyceridemia and hypertension.
‘Every body took notice of the scene of the drawing room’: Performing Emotions at the Early Georgian Court, 1714‐60
Authors: Holloway Sally , Worsley Lucy 
Published: August 2017

AbstractThis article interrogates the court's reputation as ‘the residence of dullness’ to reveal a multivalent emotional space with a practised grammar of emotional concealment and display. The performance of emotions by the royal family and courtiers in the State Apartments acted as a powerful draw to court events, as the display of joy or cheer acquired national significance. Under such scrutiny the king and his courtiers routinely limited displays of grief or pain to more restricted spaces such as the closet. The article analyses the court as a unique micro‐community in order to recreate the emotional character of London's palaces.
A sequential case series of 23 intubations in a rural emergency department in New Zealand
Authors: Powell Eleanor , Alkhouri Hatem , McCarthy Sally , Mackenzie John , Fogg Toby , Vassiliadis John , Cresswell Chris 
Published: August 2017

AbstractObjectiveTo describe the practice and procedure of emergency intubation in Whanganui Emergency Department, New Zealand and determine whether intubation can be carried out effectively in the rural setting.MethodA prospective observational study using the Australia and New Zealand Airway Registry proforma to collect data on the indication, lead intubator, first‐pass success rate and peri‐procedural complications. Data were also collected on whether a formal airway assessment was carried out and whether a checklist was used.ResultsTwenty‐three patients were intubated in the emergency department over a 12‐month period. Sixty‐two percent (14/23 cases) were medical encounters and the remaining 38% of indications due to a trauma. Head injury was the most common indication (23%). Ninety‐two percent of primary intubators were emergency department‐based Fellowship of the Australasian College for Emergency Medicine or resident medical officers, while anaesthetic‐trained operators accounted for just 8%. Our first‐pass intubation success rate was 87% and 16% of cases had procedural complications. Sixty‐five percent (15/23) carried out a formal airway assessment and a checklist was only used in 23% of cases.ConclusionThis sequential case series is the first study looking at airway management in rural New Zealand emergency department airway practice. Overall intubation success rates were comparable to larger tertiary centres across Australasia. We have demonstrated that with adequate resources and adherence to interventions, a rural emergency department can provide effective airway management.
Redo coloanal anastomosis for anastomotic leakage after low anterior resection for rectal cancer: an analysis of 59 cases
Authors: Westerduin E. , Borstlap W. A. A. , Musters G. D. , Westerterp M. , van Geloven A. A. W. , Tanis P. J. , Wolthuis A. M. , Bemelman W. A. , D'Hoore A. 
Published: August 2017

AbstractAimThe construction of a new coloanal anastomosis (CAA) following anastomotic leakage after low anterior resection (LAR) is challenging. The available literature on this topic is scarce. The aim of this two‐centre study was to determine the clinical success and morbidity after redo CAA.MethodThis retrospective cohort study included all patients with anastomotic leakage after LAR for rectal cancer who underwent a redo CAA between 2010 and 2014 in two tertiary referral centres. Short‐ and long‐term morbidity were analysed, including both anastomotic leakage and permanent stoma rates on completion of follow‐up.ResultsA total of 59 patients were included, of whom 45 (76%) were men, with a mean age of 59 years (SD ± 9.4). The median interval between index and redo surgery was 14 months [interquartile range (IQR) 8–27]. The median duration of follow‐up was 27 months (IQR 17–36). The most frequent complication was anastomotic leakage of the redo CAA occurring in 24 patients (41%), resulting in a median of three reinterventions (IQR 2–4) per patient. At the end of follow‐up, bowel continuity was restored in 39/59 (66%) patients. Fourteen (24%) patients received a definitive colostomy and six (10%) still had a diverting ileostomy. In a multivariable model, leakage of the redo CAA was the only risk factor for permanent stoma (OR 0.022; 95% CI 0.004–0.122).ConclusionRedo CAA is a viable option in selected patients with persisting leakage after LAR for rectal cancer who want their bowel continuity restored. However, patients should be fully informed about the relatively high morbidity and reintervention rates.
A reassessment of the blood–brain barrier transport of large neutral amino acids during acute systemic inflammation in humans
Authors: Dahl Rasmus H. , Berg Ronan M. G. , Taudorf Sarah , Bailey Damian M. , Lundby Carsten , Larsen Fin S. , Møller Kirsten 
Published: August 2017

SummaryWe reassessed data from a previous study on the transcerebral net exchange of large neutral amino acids (LNAAs) using a novel mathematical model of blood–brain barrier (BBB) transport. The study included twelve healthy volunteers who received a 4‐h intravenous lipopolysaccharide (LPS) infusion (total dose: 0·3 ng/kg), a human experimental model of the systemic inflammatory response during the early stages of sepsis. Cerebral blood flow and arterial‐to‐jugular venous LNAA concentrations were measured prior to and after LPS, and the BBB transport and brain extracellular concentrations of LNAAs were calculated. The arterial concentration and unidirectional cerebral influx of phenylalanine increased after LPS. The BBB transport of tyrosine was unaffected, while its concentration in the brain extracellular fluid increased. These findings suggest that LPS infusion leads to an increased cerebral uptake of phenylalanine, which is then metabolized to tyrosine. This may reflect a neuroprotective mechanism that ‘detoxifies’ excess intracerebral phenylalanine in the clinical setting of sepsis.
Measuring the end of the European financial crisis
Authors: Lin Ya‐Chi , Yeh Kuo‐Chun 
Published: August 2017

AbstractIn 2013 it was declared that ‘the eurozone crisis is over’. However, in fact, the series of financial crises since 2008 may have interrupted the process of EMU enlargement, which in turn triggered a continuing crisis of confidence in the euro. In this paper we extend the sigma‐convergence test to provide a more precise understanding of real interest rate parity (RIP) convergence. On the basis of this, we predict the timing for eliminating the cost of economic asymmetric shocks. Our estimation indicates the RIP among EMU members and accessions were still valid after the disruptions of the 2008 financial crisis. However, the situation has been even worse since the 2010 European sovereign debt crisis, and ceteris paribus, symmetry cannot be achieved without further policy actions. This implies that the EMU authority must do its best to strengthen symmetry and thereby solidify the EMU, at which point it will be better able to re‐start the process of enlargement.
Development and validation of a logic model for comprehensive medication management services
Authors: Sousa Samuel R A e , Shoemaker Sarah Joyce , do Nascimento Mariana M G , Costa Marianne S , Ramalho de Oliveira Djenane 
Published: August 2017

Abstract

Objectives
To develop and validate a theoretical logic model for comprehensive medication management (CMM) services.

Methods
The components of a logic model were constructed after a literature review and interviews with 4 CMM professionals. To validate the logic model, a panel of 17 CMM experts participated in three online Delphi method rounds to achieve consensus on the model. The consensus between the experts on each component of the logic model was evaluated using the Content Validity Index and Inter-rater Agreement in each of the rounds.

Key findings
A logic model for CMM services containing 51 items was constructed and validated. Both the items of each component of the model and the linkage between the main components were agreed upon among the experts.

Conclusions
A logic model for CMM services was developed and validated. It is an innovative tool that, if used as a theoretical framework for the implementation of CMM, can ensure greater reproducibility of CMM services in different scenarios of practice and levels of care.
Does perianth colour affect the seed germination of two desert shrubs under different storage periods and conditions?
Authors: Bhatt Arvind , Santo Andrea 
Published: August 2017

Haloxylon salicornicumandSalsola vermiculata(Amaranthaceae) are two perennial shrubs producing fruits with differently coloured perianths (yellow vs pink) on separate individuals. To test the impact of different storage periods (four, eight and twelve months) and temperature conditions (freezing, room temperature and natural field temperatures) on the seed germination of the two seed categories, germination tests were carried out on both species.For both species, collected from wild plants in the Arabian desert (Qatar), seed germination was tested under two photoperiods (light 12/12; dark 24 hours) at 20/30°C for winged (intact) and de‐winged seeds. For each species, all the considered factors (perianth colour, wing presence, photoperiod, storage period and storage conditions) had significant effects on seed germination (p < 0.001), while the interactions among factors varied in their level of significance depending on the species.In both species, yellow seeds germinated considerably better than the pink ones, the presence of wings slowed the germination, and both storage period and temperature conditions highly influenced their germination ability. Our results indicate that seeds from different perianth colours have different germination strategies to delay their germination and distribute the species through time by escaping germination time by imposing some kind of after‐ripening or seed dormancy. The variation in storage time and storage conditions might help in extending their germination period, where one set of seeds germinate immediately, and the other set of seeds becomes dormant and thus contributes to the formation of a soil seed bank for the long‐term recruitment of seedlings. This study highlights an ecological advantageous strategy for these two species growing in the unpredictable desert habitat.
Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain
Authors: Mosley Grace E. , Evashwick‐Rogler Thomas W. , Lai Alon , Iatridis James C. 
Published: August 2017

AbstractOrthopedic research into chronic discogenic back pain has commonly focused on aging‐ and degeneration‐related changes in intervertebral disc structure, biomechanics, and biology. However, the primary spine‐related reason for physician office visits is pain. The ambiguous nature of the human condition of discogenic low back pain motivates the use of animal models to better understand the pathophysiology. Discogenic back pain models must consider both emergent behavioral changes following pain induction and changes in the nervous system that mediate such behavior. Looking beyond the intervertebral disc, we describe the different ways to classify pain in human patients and animal models. We describe several behavioral assays that can be used in rodent models to augment disc degeneration measurements and characterize different types of pain. We review rodent models of discogenic pain that employed behavioral pain assays and highlight a need to better integrate neuroscience and orthopedic science methods to extend current understanding of the complex and multifactorial pathophysiology of discogenic back pain.
Foreign workers and productivity in an emerging economy: The case of Malaysia
Authors: Jordaan Jacob A. 
Published: August 2017

AbstractMany developed and developing countries are experiencing large and growing levels of international migration of labor. However, the large majority of research on the economic impact of inflows of migrant workers on host economies focuses exclusively on developed countries. In this paper, we address this gap in the literature by examining migrant‐induced productivity effects in the emerging economy of Malaysia. Importantly, the Malaysian case is typical for many Asian economies where, next to high skilled foreign workers, large numbers of migrants consist of low skilled workers that are employed in host economies on a temporary basis. Using detailed industry level data for the period 2005 to 2009, we find that both high skilled and low skilled foreign workers generate positive productivity effects in Malaysian manufacturing industries. Furthermore, our results identify a strong presence of industry heterogeneity, as the effects of foreign workers, in general, and low skilled foreign workers, in particular, are pronounced in labor and assembly intensive modern industries with a strong export focus. This indicates the importance of foreign workers for the contemporary international competitiveness of the Malaysian manufacturing sector. As such, our findings provide important new input to the debate on the role of low skilled foreign workers in processes of development of the Malaysian economy.