bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults
Authors: Harrison Theresa M. , Mahmood Zanjbeel , Lau Edward P. , Karacozoff Alexandra M. , Burggren Alison C. , Small Gary W. , Bookheimer Susan Y. 
Published: June 2016

AbstractVariants at 21 genetic loci have been associated with an increased risk for Alzheimer’s disease (AD). An important unresolved question is whether multiple genetic risk factors can be combined to increase the power to detect changes in neuroimaging biomarkers for AD. We acquired high-resolution structural images of the hippocampus in 66 healthy, older human subjects. For 45 of these subjects, longitudinal 2-year follow-up data were also available. We calculated an additive AD genetic risk score for each participant and contrasted this with a weighted risk score (WRS) approach. Each score includedAPOE(apolipoprotein E),CLU(clusterin),PICALM(phosphatidylinositol binding clathrin assembly protein), and family history of AD. Both unweighted risk score (URS) and WRS correlated strongly with the percentage change in thickness across the whole hippocampal complex (URS:r= −0.40;p= 0.003; WRS:r= −0.25,p= 0.048), driven by a strong relationship to entorhinal cortex thinning (URS:r= −0.35;p= 0.009; WRS:r= −0.35,p= 0.009). By contrast, at baseline the risk scores showed no relationship to thickness in any hippocampal complex subregion. These results provide compelling evidence that polygenic AD risk scores may be especially sensitive to structural change over time in regions affected early in AD, like the hippocampus and adjacent entorhinal cortex. This work also supports the paradigm of studying genetic risk for disease in healthy volunteers. Together, these findings will inform clinical trial design by supporting the idea that genetic prescreening in healthy control subjects can be useful to maximize the ability to detect an effect on a longitudinal neuroimaging endpoint, like hippocampal complex cortical thickness.
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease
Authors: Villaescusa J Carlos , Li Bingsi , Toledo Enrique M , Rivetti di Val Cervo Pia , Yang Shanzheng , Stott Simon RW , Kaiser Karol , Islam Saiful , Gyllborg Daniel , Laguna‐Goya Rocio , Landreh Michael , Lönnerberg Peter , Falk Anna , Bergman Tomas , Barker Roger A , Linnarsson Sten , Selleri Licia , Arenas Ernest 
Published: June 2016

AbstractPre‐B‐cell leukemia homeobox (PBX) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mDAn) as well as their role in neurodegenerative diseases are unknown. Here, we show that PBX1 controls a novel transcriptional network required for mDAn specification and survival, which is sufficient to generate mDAn from human stem cells. Mechanistically, PBX1 plays a dual role in transcription by directly repressing or activating genes, such as Onecut2 to inhibit lateral fates during embryogenesis, Pitx3 to promote mDAn development, and Nfe2l1 to protect from oxidative stress. Notably, PBX1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 levels increases damage by oxidative stress in human midbrain cells. Thus, our results reveal novel roles for PBX1 and its transcriptional network in mDAn development and PD, opening the door for new therapeutic interventions.
Parental Country of Birth and Childhood Vaccination Uptake in Washington State
Authors: Wolf Elizabeth , Rowhani-Rahbar Ali , Tasslimi Azadeh , Matheson Jasmine , DeBolt Chas 
Published: June 2016

BACKGROUND:
Underimmunization of certain immigrant populations can place them at high risk of experiencing vaccine-preventable disease outbreaks.

METHODS:
We conducted a retrospective cohort study between January 1, 2008, and May 1, 2013, among children included in the Washington State Immunization Information System. We assessed receipt of 1 or more doses of measles-containing, hepatitis A, pneumococcal, and diphtheria-tetanus-acellular pertussis-containing vaccines between 12 and 23 months of age. We compared children with 1 or more parents born in Somalia, Ukraine, Russia, Mexico, or India to children with 2 parents born in the United States. Poisson regression models with robust SEs were used to provide prevalence ratios adjusted for maternal education and number of prenatal visits.

RESULTS:
We identified 277 098 children, including 65 466 with foreign-born parents. Children of Somali-born parents were less likely to be immunized against measles than children of US-born parents (prevalence ratio: 0.82; 95% confidence interval: 0.80–0.84); this decrease became more pronounced over time (P &lt; .01). No such disparity between these groups was observed with other vaccines. Compared with children of US-born parents, children of Ukrainian-born and Russian-born parents were less likely to be immunized, whereas children of Mexican-born and Indian-born parents were more likely to be immunized with any of the specified vaccines.

CONCLUSIONS:
We found country-specific patterns of immunization that may reflect underlying cultural or other beliefs. Certain immigrant communities with higher rates of immunization refusal may be at risk for vaccine-preventable diseases and require new forms of public health outreach.
Editorial
Authors: Figueroa Muñoz Mario Bernardo 
Published: June 2016

<p>Desde el Jardín de Freud se encuentra indexada en el IBN-Publindex (Colciencias), en categoría C, y en las siguientes bases de datos y catálogos: EBSCO, ProQuest, CLASE, Latindex, Dialnet, Rebiun, Doaj, e-Revistas y Biblioteca virtual Luis Ángel Arango.</p>
Tomar la palabra: el acontecimiento de la verdad en el testimonio
Authors: Hernández Iván 
Published: June 2016

<p>La cuestión de la verdad ocupa un lugar de gran importancia en la consolidación de los procesos de negociación política que conducen al fin de la guerra y a la reconstrucción del lazo social en el posconflicto. En ese contexto, el testimonio de las víctimas corre el riesgo de terminar siendo instrumentalizado, por los dispositivos jurídicos y los archivos de la memoria histórica, en la empresa política del establecimiento de una verdad conveniente. Sin embargo, el psicoanálisis advierte sobre esa dimensión de acontecimiento de la verdad, que impugna al discurso en su pretensión de domesticarla, de hacerla dócil a los límites que él mismo le señala. En tanto que el testimonio supone una toma de la palabra, se hace necesario preguntarse por el lugar del sujeto que allí adviene y la verdad que le concierne.</p>
Nietzsche y Freud ante el problema de la verdad
Authors: Drivet Leandro 
Published: June 2016

<p>Este trabajo se propone reflexionar acerca del problema de la verdad en las obras de Friedrich Nietzsche y Sigmund Freud, a las que se considera estrechamente vinculadas. Esta perspectiva permitirá identificar el carácter específico de la “verdad”, cuyos vestigios detectaron ambos “psicólogos” transvaloradores; apreciar la doble valoración nietzscheana de la verdad, usualmente reducida a un rechazo unilateral; y repensar la pretensión de cientificidad del psicoanálisis, actualmente despreciada en nombre de una sospechosa reivindicación anticientífica. Se concluye con el postulado de que Nietzsche y Freud conciben a la verdad como una lucha contra las resistencias, lo que les conduce a fundar una nueva escucha.</p>
¿Qué tanto le debe Freud a Brentano?
Authors: Bustamante Zamudio Guillermo 
Published: June 2016

<p>Sigmund Freud tomó clases con el filósofo Franz Brentano. ¿Implica que los conceptos del psicoanalista tengan una deuda con los del filósofo? Freud tenía un anclaje en la clínica y temía al pensamiento sin ataduras. Brentano tenía por anclaje la lógica de los argumentos. Las decisiones de Freud se alejan de los criterios de Brentano; de manera que si hemos de tomar el paquete de la clínica y de la teoría que intenta estar a su altura, el psicoanálisis poco tiene que ver con la psicología empírica brentaniana. Se analiza el texto La negación de Freud, contrastándolo con el intento de Agustín Kripper para ubicar en ese texto la presencia de Brentano.</p>
El cardo, el ave y la verdad. Entrevista con el pintor Antonio López
Authors: Peynot Jean-Philippe 
Published: June 2016

<p>Antonio López es reconocido como uno de los más grandes pintores actuales por numerosas instituciones y por un público muy amplio. Al escoger pintar su entorno más cercano, de manera realista y sin imponer siquiera un estilo, supo que su camino sería difícil y solitario, lejos de los críticos de arte, curadores, galeristas y otros actores de la escena contemporánea. De la fidelidad de su mirada nació una obra, y de esta obra nació el pintor, que nos habla en esta entrevista, al horizonte de una verdad. Entre otros reconocimientos Antonio López recibió el Premio Príncipe de Asturias de las Artes en 1985 y el Premio Velázquez de Artes Plásticas en 2006.</p>
Adaptación de dos medidas de apoyo social en estudiantes universitarios argentinos
Authors: Zalazar Jaime Mauricio Federico , Cupani Marcos 
Published: June 2016

<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>El soporte social constituye un importante constructo en el ámbito educativo, el cual influye en términos comportamentales, cognitivos y afectivos. Aunque en la literatura internacional existen numerosos instrumentos que permiten evaluar dicho constructo, en Argentina no se dispone de escalas que permitan evaluar el apoyo percibido por los estudiantes. Por tanto, el objetivo de este trabajo consistió en adaptar las escalas de Apoyo Social para Niños y Adolescentes (Malecki, Demaray &amp; Elliot, 2003) y Soporte Académico (Lent et al., 2005) en estudiantes universitarios. Para ello, en este estudio participaron 551 estudiantes de diferentes carreras dictadas en la Universidad Nacional de Córdoba (Argentina). Para ambos instrumentos, los resultados indicaron valores satisfactorios de consistencia interna (confiabilidad compuesta, </span><span>ρ </span><span>&gt; .70) y, además, se logró replicar la estructura original de cada medida mediante análisis factorial confirmatorio. Se destacan las limitaciones y se sugieren nuevas líneas de estudio. </span></p></div></div></div></div>
Опыт моделирования культуры как социальной системы
Authors: Флиер Андрей Яковлевич 
Published: June 2016

<p>Теоретическое осмысление культуры включает в себя множество вопросов, варианты ответов на которые формируют определенную концепцию научной интерпретации феномена культуры. Иерархию вопросов определяет каждый ученый в соответствии со своим мировоззрением и восприятием культуры. Автор считает, что главным инструментом научного самоопределения являются индивидуальные познавательные интересы ученого. Соответственно, и авторская модель теории культуры отражает определенный историко-социологический подход к пониманию культуры.</p><p>В ракурсе этой научной позиции автор ставит и решает следующие вопросы. Что такое культура, каковы ее основные социальные функции и морфология? Что является основной причиной исторической устойчивости культуры и наиболее значимым двигателем ее исторической изменчивости? Каковы возможные принципы научного познания культуры?</p><p>Культуру автор определяет как поведенческую программу обеспечения коллективного характера жизнедеятельности людей. Таким образом, вопрос о сущности культуры расширяется до проблемы человеческого социального поведения, включающего в качестве главных составляющих и деятельность, и взаимодействие. Культура — это основной инструмент нормативно-поведенческого и коммуникативного обеспечения человеческой жизнедеятельности в коллективных формах, т. е. главное проявление социальности людей. Структура культуры соответствует основным направлениям социальной практики.</p><p>Основными причинами исторической устойчивости и изменчивости культуры являются устойчивость и изменчивость технологий деятельности человека и предпочитаемых форм продуктов (результатов) этой деятельности (как материальных, так и интеллектуальных, художественных, социальных, политических и пр.).</p><p>Проблему разнообразия методологий научного познания культуры автор основывает на трех парадигмальных этапах развития рациональности (по В. С. Степину): классическом, неклассическом и постнеклассическом.</p><p>Главная научная проблема культурологии, считает автор, состоит в поиске адекватного понимания культурных артефактов и их актуального интерпретирования. И здесь многое зависит от точности выбора познавательного ракурса исследования. </p>
Социально-психологические факторы, способствующие и препятствующие первичному отказу от табакокурения (на примере исследования курящих девушек)
Authors: Максименко Александр Александрович , Пичугина Екатерина Георгиевна 
Published: June 2016

<p>В статье представлены программа и результаты исследования факторов и механизмов, способствующих и препятствующих вовлечению в курение и отказу от него (на примере исследования курящих молодых девушек). В основе данного исследования лежит предположение, что мотивы курения сильно дифференцированы и обусловливают разную расположенность к отказу от курения. Целью исследования является выделение факторов и механизмов, способствующих и препятствующих вовлечению девушек в курение и отказу от него, и выделение на этой основе сегментов курильщиц. Исследование было проведено в 2011–2012 гг., объектом выступили курящие девушки 15–24 лет (жители г. Кострома, Россия). Для сбора эмпирических данных использована авторская анкета «Факторы вовлечения и отказа от курения».</p><p>На основании факторного анализа были выделены группы мотивов курения, которые легли в основу сегментации курильщиц. Группы респондентов можно дифференцировать по содержанию компонентов мотивации к табакокурению (имиджмейкеры, гедонисты, социальные, иррациональные курильщицы). Выявлен важный факт изменения мотивации к курению с увеличением стажа: среди курильщиц с наибольшим стажем преобладают «социальные курильщицы» и «курильщицы-гедонисты».</p><p>Также были выявлены компоненты мотивации к отказу от табакокурения — негативные физиологические ощущения, разочарование в тех или иных выгодах от курения, осознание нелогичности курения, серьезные заболевания в будущем. При этом для разных групп курильщиц отмечается различный набор стимулов к отказу, что определяет дифференцированный подход к воздействию на курильщиц в рамках антитабачных мероприятий.</p><p>Результаты такого исследования могут являться основанием для разработки антитабачных мероприятий. Актуальной и перспективной научной проблемой является изучение социально-психологических факторов первичного отказа от табакокурения и психологических особенностей некурящих людей (потенциальных курильщиков).</p>
New occurrences and biological aspects to four species of rodents (Mammalia: Cricetidae) from Brazil
Authors: Machado Felipe Santana , Lima Ivan Junqueira , Lopes Arina Pacheco Magalhães , Moura Aloysio Souza de , Abreu Thamíris Christina Karlovic de 
Published: June 2016

The most representative group among mammals are rodents for presenting high ratio to the total of species. However, rodents are considered a "taxonomic chaos" and some species such as Blarinomys breviceps, Bibimys labiosus, Akodon lindberghi and Pseudoryzomys simplex are little known. That can be explained because of low occurrence of small terrestrial mammals in wildlife inventories and/or reduced abundance. The objective is to describe the occurrence of these species and analyze these locations presenting descriptive comments about their biological aspects. Therefore, in addition to specimens collected in the field, some scientific collections were visited and reviews in relevant literature were conducted in order to obtain information about the locations and biological aspects. Akodon lindberghi was found in five sites, Bibimys labiosus was found in 15, Blarinomys breviceps in 39 and Pseudoryzomys simplex in 13. Each species has specific information and they are included in two threatened areas, Atlantic Forest and Cerrado. The occurrences are disconnected and related to taxonomic and methodological problems.Keywords: New records. Rodentia. Sigmodontinae. Occurence area.
ARQUEOLOGIA COLABORATIVA NA AMAZÔNIA: TERRA INDÍGENA KUATINEMU, RIO XINGU, PARÁ
Authors: Silva Fabíola Andréa , Bespalez Eduardo , Stuchi Francisco Forte 
Published: June 2016

Apresentaremos os procedimentos e primeiros resultados da pesquisa arqueológica e etnoarqueológica realizada em maio de 2010, com o objetivo de localizar os antigos assentamentos Asurini às margens do igarapé Ipiaçava e verificar o potencial arqueológico dessa parte da T.I. Kuatinemu. Mostraremos que os arqueólogos e os Asurini protagonizaram o projeto, contribuindo com diferentes interesses e expertises na sua elaboração, organização logística, cronograma de atividades ena interpretação dos vestígios materiais encontrados. Relatando esta experiência, queremos contribuir ao debate sobre as práticas reflexivas e multivocais, destacando as contribuições que o diálogo multicultural e a expressão de diferentes formas de conhecimento e historicidade trazem à Arqueologia. Palavras-chave: arqueologia colaborativa, multivocalidade, Asurini do Xingu.
JUNTANDO CACOS: UMA REFLEXÃO SOBRE A CLASSIFICAÇÃO DA FASE KORIABO NO AMAPÁ
Authors: Cabral Mariana Petry 
Published: June 2016

Ao ampliar a pesquisa arqueológica no Amapá, emergiram contextos inéditos, exigindo reflexão sobre como classificar o material. A discussão que realizo aqui tem início com uma investigação sobre a forma como a fase Koriabo tem sido utilizada em outras áreas do Escudo Guianense. Os usos que têm sido feitos, na maior parte dos casos, do termo Koriabo na arqueologia da região, como busco demonstrar, têm um caráter generalizador. Como decorrência, as semelhanças são ressaltadas e as diferenças negligenciadas, com uma forte tendência à homogeneização. No entanto, escavações recentes na Guiana Francesa e no Amapá apontam para contextos diversos de deposição desta cerâmica característica. A partir daí, volto-me ao contexto no Amapá, salientando o quanto escavações amplas com informações detalhadas oferecem novas bases para refletirmos sobre as classificações, já que enriquecem nosso conhecimento sobre os contextos arqueológicos de deposição. A partir da reflexão que apresento aqui, sugiro que, no contexto da arqueologia das Guianas, é necessário ampliar o foco em contextos particulares antes de nos voltarmos às classificações generalistas, a fim de refinar dados e nossas interpretações. Palavras-chave: fase Koriabo, arqueologia das Guianas, classificação.
A New Matrix/Fracture Multiscale Coupled Model for Flow in Shale-Gas Reservoirs
Authors: Le Tien Dung , Murad Márcio A. , Pereira Patrícia A. 
Published: June 2016

Summary
A new computational model for coupled gas flow in hydraulic fractures and multiporosity shale matrix is developed within the framework of multiscale modeling. The hydrodynamics in the network of hydraulic fractures are constructed by averaging the mass-conservation equation across the fracture aperture, giving rise to an averaged balance law supplemented by a source term arising from the jump in the gas flux from the shale matrix. The resultant flow equation in the fracture is coupled with a new pressure equation that governs the averaged gas movement in the shale matrix. Such a pressure equation exhibits a new storage coefficient and is rigorously derived by homogenizing the pore-scale model of gas flow in the interparticle pores, partially saturated with water, lying adjacent to the nanopores within the kerogen and impermeable inorganic matter composed of a reactive clay and an inert solid. The free gas at the interparticle pores is assumed at local thermodynamic equilibrium with the dissolved gas in the water and adsorbed gas lying in the nanopores of the kerogen aggregates and at the surface of the active clay. The constitutive laws for the partition coefficients, which appear in the pressure equation, are derived from the adsorption isotherms, which are rigorously constructed from the thermodynamics of confined gases on the basis of the density-functional-theory (DFT) approach. Numerical simulations of both canonical and real computational examples of gas primary recovery in the Barnett, Marcellus, and Eagle Ford formations illustrate the potential of the multiscale approach proposed herein in computing production in different flow regimes.
Evaluation of Nitrogen Fertilizer and Cultivation Methods for Agronomic Performance of Rice
Authors: Mi Wenhai , Yang Xin , Wu Lianghuan , Ma Qingxu , Liu Yanling , Zhang Xuan 
Published: June 2016

Nitrogen fertilization and cultivation methods are the two principal management approaches used in agronomy to determine the growth and grain yield of rice. In this study, a field experiment was conducted to evaluate the performance of three cultivation methods (conventional manual transplanting of field‐grown seedlings [TFS], direct seeding [DS], and transplantation of glasshouse‐grown seedlings followed by manual transplanting [TGS]) under two N management treatments (split applications of urea [PU] vs. a single basal application of a controlled‐release fertilizer [CRF]) for growing rice under a subtropical monsoon climate in China (2011–2014). Annual grain yield, yield components, and total biomass were determined at maturity over the 4‐yr experiment. We also measured the dry matter, leaf area index, leaf area duration, and leaf chlorophyll “greenness” of rice at key growth stages. Over the 4 yr, the comparative grain yield of CRF significantly exceeded that of PU with TFS and TGS by 7.7 and 5.2%, respectively, suggesting that CRF was best for transplanted rice. In the case of DS, however, CRF reduced grain yield by 3% compared with PU. The grain yields of TFS and TGS were significantly higher than that of DS rice (by 8.2 and 11.6%, respectively) under the PU treatment and were higher under the CRF treatment (by 20 and 21%, respectively). Our results suggest that these two transplanting methods, when coupled to controlled‐release fertilizer management, could be an effective way to achieve higher rice grain yields.Core Ideas

Controlled‐release fertilizer increased the grain yield compared with urea for transplanting rice.
Split applications of urea produced more grain yield than controlled‐release fertilizer for direct seeding rice.
Conventional manual transplanting of field‐grown seedlings and glasshouse‐grown seedlings followed by manual transplanting produced higher grain yield than direct seeding, irrespective of how N was managed.
Apuntes desde la ciencia económica ¿el sujeto racional o el sujeto complejo
Authors: Gómez Rodríguez Dustin Tahisin 
Published: June 2016

El siguiente artículo es un breve análisis del imaginario del sujeto racional del discurso hegemónico de la ciencia económica actual, en contraposición con el sujeto complejo propuesto por Morin, como ápice de una posible revolución científica denominada bioeconomía. La metodología es de tipo documental y exploratoria, en la cual se hace una revisión de literatura especializada por medio de matrices. La conclusión más relevante es que el discurso oficial de la ciencia económica del sujeto racional ha pasado por alto, que su desmedido afán depredador de la naturaleza, eventualmente, estimulará su propia extinción.