bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blockchain and the lifecycle of components—An approach
Authors: Meinen Heiko , Dreyer Julian , Kock Katrin , Huebner Roman 
Published: September 2024

AbstractBuildings involve multiple participants and materials that must work together throughout their life cycle, from initial planning to decommissioning and recycling. This can create safety concerns, particularly with regard to critical components. Detailed documentation and tracking of product characteristics are necessary, as well as outlining the related obligations of the parties involved. Currently, this problem is often addressed by numerous contracts and paper‐based building documentation. Blockchain technology could prove to be a future‐oriented solution to such use cases. Additionally, so‐called Smart Contracts, which are custom‐designed applications running on the given Blockchain platform, can be an appropriate way for documentation in the construction and facility management process since they allow distribution of their execution to the entirety of the involved Blockchain participants. Based on this approach, this paper presents a platform solution that provides up‐to‐date product information on various components. The outcome is a system that facilitates digital documentation on a secure legal foundation, with an interface tailored to the specific terms and conditions of each partner involved in the construction and maintenance process.
Pyridalthiadiazole‐Based Molecular Chromophores for Defect Passivation Enables High‐Performance Perovskite Solar Cells
Authors: Min Zhangtao , Wang Bei , Kong Yuxin , Guo Junjun , Ling Xufeng , Ma Wanli , Yuan Jianyu 
Published: September 2024

AbstractPassivation of defects at the surface and grain boundaries of perovskite films has become one of the most important strategies to suppress nonradiative recombination and improve optoelectronic performance of perovskite solar cells (PSCs). In this work, two conjugated molecules, abbreviated as CPT and SiPT, are designed and synthesized as the passivator to enhance both efficiency and stability of PSCs. The CPT and SiPT contain pyridalthiadiazole (PT) units, which can coordinate with undercoordinated Pb2+ at the surface and grain boundaries to passivate the defects in perovskite films. In addition, with the incorporation of CPT, the crystallized perovskite films exhibit more uniform grain size and smoother surface morphology relative to the control ones. The efficient passivation by CPT also results in better charge extraction and less carrier recombination in PSCs. Consequently, the CPT‐passivated PSCs yield the highest power conversion efficiency (PCE) of 23.14 % together with better storage stability under ambient conditions, which is enhanced relative to the control devices with a PCE of 22.14 %. Meanwhile, the SiPT‐passivated PSCs also show a slightly enhanced performance with a PCE of 22.43 %. Our findings provide a new idea for the future design of functional passivating molecules towards high‐performance PSCs.
A case of gastrointestinal perforation following transarterial embolization for an intramural hematoma after cold snare polypectomy of an adenoma in the transverse colon
Authors: Kodama Yuu , Mizokami Yuji , Toyama Yuzo , Kusaka Hiroyasu , Maeda Gen , Asahara Shingo , Nagahama Ryuji , Horiguchi Shin‐ichiro , Aoyama Hiroki 
Published: September 2024

AbstractWe encountered a case of a large hematoma developing with perforation shortly after a cold snare polypectomy for a colorectal adenoma. The patient underwent cold snare polypectomy for a 3‐mm type Is lesion in the transverse colon at another facility. Two hours later, she visited the emergency room due to abdominal pain. Contrast‐enhanced computed tomography revealed a 70 mm, high‐intensity mass in the transverse colon with contrast extravasation. We attempted transcatheter arterial embolization to stop the bleeding. Several hours later, the anemia had not worsened, but the severe abdominal pain persisted. Urgent laparoscopic right hemicolectomy was performed due to the possibility of gastrointestinal perforation. The surgery was successfully completed. Pathology reports confirmed the presence of an intramural hematoma in the proximal transverse colon with hemorrhagic infiltration of all layers, along with extensive ischemic changes. A perforation was identified in this area, with mucosal defects observed near the hole, possibly due to cold snare polypectomy.
Numerical study of dynamic stall effects on VR‐12 airfoil with pitch oscillation and accelerated inflow
Authors: Zolghadr Behzad , Khoshnevis Abdolamir B. 
Published: September 2024

AbstractThis study investigates the effects of positive horizontal acceleration of the freestream velocity on a pitch‐oscillating VR‐12 airfoil using computational fluid dynamics. The shear stress transport k–ω model, coupled with a low‐Reynolds number correction, was employed for Re <105 during dynamic stall. The flow equations were solved in two‐dimensional, incompressible form using the finite volume method. The study examined various parameters, including positive acceleration values of the inflow and the angle of attack of the airfoil, to determine their impact on lift and drag coefficients, as well as the ratio. Additionally, the maximum lift coefficient was analyzed under different inflow and airfoil motion conditions. The results indicate that aerodynamic force coefficients and the ratio are influenced by both the attack angle and the acceleration of the inflow. Furthermore, inflow acceleration affects the onset of dynamic stall conditions. Generally, inflow acceleration modifies the lift coefficient of the airfoil during the upstroke, while having minimal effect on the drag coefficient, except near dynamic stall points. The findings also suggest that, for a specific airfoil, the sequence of factors with the greatest influence on lift force generation before static stall occurs is as follows: asymmetric airfoil oscillation, symmetrical airfoil oscillation, accelerated inflow, constant velocity inflow, and static airfoil.
Analysis of the load‐bearing characteristics of hydraulic supports for top‐coal caving under the impact of coal and gangue
Authors: Cao Lianmin , Xu Yongxin , He Can , Zhang Enming , Miao Yingfa 
Published: September 2024

AbstractTo study the effect of different sizes and speeds of coal gangue falling on hydraulic supports for top‐coal caving discharge hydraulic support on the bearing characteristics of the hydraulic support, the ADAMS hydraulic support rigid‐flexible coupling analysis model was established. HyperMesh is used to flexibly process the hydraulic support, and the column and jack are equivalently replaced by spring damping system. By applying step loads of different sizes and speeds to simulate the impact force generated when the coal gangue falls on different positions of the cover beam, the dynamic response characteristics of the column, balance jack and other articulation points are obtained. Analyses show that: when the impact load is closer to the roof beam, the articulation point of the roof beam‐cover beam and the balancing jack are easy to be damaged. When the same impact load is applied to the cover beam, the faster the load is applied, the hydraulic support column and balancing jack may not be able to absorb and disperse the pressure effectively in time, resulting in the articulation points being subjected to a larger impact force, which is easy to cause damage or destruction. When different sizes and speeds of impact loads are applied to the cover beam, the latter has a greater impact on the dynamic response of the front and rear connecting rod articulation points and the cover beam‐roof beam articulation point than the former, and the hydraulic bracket will be more prone to vibration, deformation, and stress concentration, thus affecting the stability and safety of the bracket. The article is of guiding significance for designing and optimizing the structure and parameters of the hydraulic support, and improving the support performance and stability of the hydraulic support in the comprehensive release working face.
Comparing lactic acid bacteria biodiversity in irritable bowel syndrome and healthy gut microbiota
Authors: Azimi Aysooda , Yavarmanesh Masoud , Gholamin Mehran 
Published: September 2024

AbstractIrritable bowel syndrome (IBS) is a prevalent gut disorder linked to changes in the gut microbiota, including lactic acid bacteria (LAB). However, research on LAB biodiversity in IBS patients is limited. This study aimed to compare LAB microbiota in healthy individuals and those with IBS through biochemical and molecular techniques. Fecal samples from 15 IBS patients and 13 healthy individuals were collected, and LAB were isolated using biochemical methods. Fifty isolates were chosen based on Gram staining and catalase tests and identified through 16S rRNA gene sequencing. A phylogenetic tree was used to analyze strain diversity, and correlation diagrams and swarm plots were employed to explore variable relationships. The study revealed a significant difference in LAB numbers between IBS and healthy subjects, with average of 5.91 and 6.63, respectively. Most bacteria were Gram‐positive cocci or bacilli, with homofermentative characteristics, except for one heterofermentative sample from the healthy group. Both IBS and healthy groups exhibited strains from Lactobacillus and Enterococcus genera, with Enterococcus faecium being predominant in both. Demographic analysis showed higher IBS prevalence among individuals aged 20–40, with IBS‐C more common in women and IBS‐D in men. The study concluded that individuals with IBS had significantly lower LAB microbiota counts, potentially impacting intestinal defense function. Further exploration of LAB behavioral and immunomodulatory traits may enhance understanding of intestinal microbiota's role in IBS and aid in developing treatment strategies.
Efficacy of virtual reality therapy versus pharmacological sedation for reducing pain and anxiety during coronary catheterisation procedures: A prospective randomised controlled trial
Authors: Verain Julien , Trouillet Charlotte , Moulin Fréderic , Christophe Charles 
Published: September 2024

AbstractBackground and AimsThe use of virtual reality (VR) therapy has grown considerably, as it is effective for reducing pain and anxiety in different clinical areas. However, it has not been well evaluated for coronary angiography and angioplasty. This study aimed to compare VR therapy with pharmacological sedation (Sedation) for reducing pain in patients undergoing a planned coronary angiography or coronary/peripheral angioplasty.MethodsIn this prospective randomized controlled trial, patients were randomly allocated to one of two groups before catheterization: a Sedation group (injection of midazolam and fentanyl) or a VR group (Deepsen VR headset). The primary outcome measure was the maximum pain during the procedure (visual analogue scale: 0–10). The secondary outcome measures were anxiety following the procedure (Spielberger State Anxiety Inventory: 20–80), the occurrence of arterial spasm, the haemodynamic profile and patient satisfaction.ResultsThe VR group (n = 63) had a mean pain rating of 2.5; for the Sedation group (n = 59) this was 1.0. This did not meet the criterion for non‐inferiority. Anxiety was comparable between the two groups (VR: 25.4; Sedation: 24.7), as was the occurrence of arterial spasm (VR: 7.9%; Sedation: 8.5%; p = 0.91), but blood pressure was higher in the VR group (140.2/71.7 mmHg vs. 121.8/64.7 mmHg). There were no VR‐related adverse effects, and patient satisfaction was high for both groups.ConclusionsVirtual reality therapy was not non‐inferior to pharmacological sedation for reducing pain during coronary angiography or angioplasty. However, it reduced anxiety to a comparable level. Virtual reality therapy represents an alternative to pharmacological sedation, which is well accepted by patients.
The trends and outcomes of inflammatory bowel disease surgery during the COVID‐19 pandemic: A retrospective propensity score‐matched analysis from a multi‐institutional research network
Authors: Wu Fiona , Ibarburu Gema H. , Grimes Caris 
Published: September 2024

AbstractBackground and AimsThe coronavirus disease 2019 (COVID‐19) pandemic has affected the management of inflammatory bowel disease (IBD) patients. Elective operations and surveillance endoscopies were postponed for IBD patients to preserve healthcare resources and to prevent the spread of COVID‐19. This study aimed to describe the trends and outcomes of IBD surgery during the pandemic.MethodsThis was a retrospective propensity score‐matched analysis using data extracted from TriNetX, a multi‐institutional research database. IBD patients admitted for surgery were identified between March 2019 to February 2020 (prepandemic) and March 2020 to February 2023 (pandemic). The monthly volume of IBD surgical procedures was compared during the pandemic to the prepandemic period. After matching, the risk of adverse outcomes following IBD surgery was compared between the 3 years of the pandemic compared to the prepandemic cohort.ResultsThere was a reduction in both elective and emergency IBD operations during the pandemic. These trends were not significant. After matching, the risks of returning to theaters and hospital readmission were comparable across the 3 years of the pandemic. In the first and second years of the pandemic, elective patients were at a greater risk of mortality (risk ratio [RR], 2; 95% confidence interval [CI], 1.160–3.448 and RR, 1.778; 95% CI, 1.003–3.150, respectively) and the emergency cohort had a higher risk of critical care admission (RR, 1.759; 95% CI, 1.126–2.747 and RR, 1.742; 95% CI, 1.131–2.682, respectively).ConclusionOur study highlights the impact of the COVID‐19 pandemic on the management of IBD patients undergoing surgery. These results provide insights into the management of IBD surgery during times of crisis and can help guide decision‐making and resource allocation for IBD patients requiring surgical intervention.
Potential association between allergenic food exposure and skin disease in Bangladesh: An application of principal component logistic regression (PCLR)
Authors: Khan Md. Abrar Ashfaq , Babu Md. Rashed , Tasnim Sumaiya , Tarannum Atiya , Haque Mohammad Anamul , Sultana Nahid , Ullah Mohammad Ohid 
Published: September 2024

AbstractBackground and AimAllergenic foods can trigger skin conditions, yet their impact in Bangladesh remains underexplored. This study aims to investigate the potential association between exposure to allergenic foods and the development of skin disease across Bangladesh.MethodsWe conducted a cross‐sectional survey with 970 respondents from the divisions of Dhaka, Sylhet, Rangpur, and Chattogram who self‐reported skin disease triggered by food allergens. We analyzed the data using multiple response analysis and principal component logistic regression.ResultsApproximately 64% of respondents had skin disease attributable to allergenic foods, with a relatively higher proportion among females (52%) than males (48%). Beef (67%), Brinjal (47.1%), Hilsa (45.8%), and Shrimp (23.7%) were the most frequently cited allergenic foods. Principal component logistic regression identified two highly significant principal components: the first representing Hilsa, Beef, and Brinjal (odds ratio = 2.256), and the sixth reflecting Corn (odds ratio = 1.342). Individuals who consumed foods with high loadings of the first principal component were 125.6% more likely to develop skin disease than nonconsumers, while those exposed to Corn had a 34.2% higher risk.ConclusionThe findings highlight prevalent allergenic foods in Bangladesh and their substantial impact on skin health, underscoring the need for dietary awareness and tailored interventions to mitigate allergic skin conditions in this population.
Embracing complexities in agricultural water management through nexus planning
Authors: Smith Mark D. , Sikka Alok , Taguta Cuthbert , Dirwai Tinashe L. , Mabhaudhi Tafadzwanashe 
Published: September 2024

AbstractA major challenge for agricultural water management (AWM) in the 21st century is to feed a growing population in the face of increasing intersectoral resource competition, evolving diets, degradation, pandemics, geopolitical conflicts and climate change. This has to be achieved within the planetary boundaries and without compromising the livelihood and environmental (ecosystem) objectives linked to water, including provisioning, supporting and regulating services. This paper uses a systems and nexus lens to unravel the centrality and complexities in AWM, with particular emphasis on the interconnected dimensions and objectives of AWM, as well as its practices and technologies. AWM exists beyond water and food with linkages to human and environmental well‐being. AWM needs to catalyse transformation and integrate approaches across systems, users and scales to meet its objectives in a changing climate. It must provide perspectives beyond productivity, managing water risks and safeguarding food security – as important as these are – and integrate our understanding of the interconnected climate, land, water, food and ecosystems to address planetary health outcomes. By doing so, AWM could catalyse contextualised, equitable, innovative solutions that acknowledge local socio‐economic and institutional structures and limitations while catalysing sustainable development and climate resilience.
Assessing the Inhibitory Potential of Pregnenolone Sulfate on Pentraxin 3 in Diabetic Kidney Disease: A Molecular Docking and Simulation Study
Authors: Das Soumik , Ramanathan Gnanasambandan 
Published: September 2024

ABSTRACTDiabetic Kidney Disease (DKD), a frequent consequence of diabetes, has substantial implications for both morbidity and mortality rates, prompting the exploration of new metabolic biomarkers due to limitations in current methods like creatinine and albumin measurements. Pentraxin 3 (PTX3) shows promise for assessing renal inflammation in DKD. This study investigates how DKD metabolites could influence PTX3 expression through molecular docking, ADMET profiling, and dynamic simulation. Network and pathway analyses were conducted to explore metabolite interactions with DKD genes and their contributions to DKD pathogenesis. Thirty‐three DKD‐associated metabolites were screened, using pentoxifylline (PEN) as a reference. The pharmacokinetic properties of these compounds were evaluated through molecular docking and ADMET profiling. Molecular dynamics simulations over 200 ns assessed the stability of PTX3 (apo), the PRE‐PTX3 complex, and PEN‐PTX3 across multiple parameters. Cytoscape identified 1082 nodes and 1381 edges linking metabolites with DKD genes. KEGG pathway analysis underscored PTX3's role in inflammation. Molecular docking revealed pregnenolone sulfate (PRE) with the highest binding affinity (−6.25 kcal/mol), followed by hydrocortisone (−6.03 kcal/mol) and 2‐arachidonoylglycerol (−5.92 kcal/mol), compared to PEN (−5.35 kcal/mol). ADMET profiling selected PRE for dynamic simulation alongside PEN. Analysis of RMSD, RMSF, RG, SASA, H‐bond, PCA, FEL, and MM‐PBSA indicated stable complex behavior over time. Our findings suggest that increasing PRE levels could be beneficial in managing DKD, potentially through isolating PRE from fungal sources, synthesizing it as dietary supplements, or enhancing endogenous PRE synthesis within the body.
A Novel Assay Reveals the Early Setting‐Up of Membrane Repair Machinery in Human Skeletal Muscle Cells
Authors: d'Agata Léna , Rassinoux Phoebe , Gounou Céline , Bouvet Flora , Bouragba Dounia , Mamchaoui Kamel , Bouter Anthony 
Published: September 2024

ABSTRACTDefect in membrane repair contributes to the development of muscular dystrophies such as limb girdle muscular dystrophy (LGMD) type R2 or R12. Nevertheless, many other muscular dystrophies may also result from a defect in this process. Identifying these pathologies requires the development of specific methods to inflict sarcolemma damage on a large number of cells and rapidly analyze their response. We adapted a protocol hitherto used to study the behavior of cancer cells to mechanical constraint. This method is based on forcing the passage of cells through a thin needle, which induces shear stress. Due to size considerations, this method requires working with mononuclear muscle cells instead of myotubes or muscle fibers. Although functional sarcolemma repair was thought to be restricted to myotubes and muscle fibers, we show here that 24h‐differentiated myoblasts express a complete machinery capable of addressing membrane damage. At this stage, muscle cells do not yet form myotubes, revealing that the membrane repair machinery is set up early throughout the differentiation process. When submitted to the shear‐stress assay, these cells were observed to repair membrane damage in a Ca2+‐dependent manner, as previously reported. We show that this technique is able to identify the absence of membrane resealing in muscle cells from patient suffering from LGMDR2. The proposed technique provides therefore a suitable method for identifying cellular dysregulations in membrane repair of dystrophic human muscle cells.
Assessing gaps in predoctoral dental curriculum for LGBTQ+ specific content
Authors: Tamayo‐Cabeza Guillermo , Albright Amanda , Yalamanchi Sriha , Newton April D. , Weber Zachary A. , Shukla Anubhuti 
Published: September 2024

ABSTRACTBackgroundDespite growing recognition of health disparities faced by the Lesbian, Gay, Bisexual, Transgender, Queer (or Questioning) (LGBTQ+) population, significant gaps remain for inclusion of LGBTQ+ content in health professions education, particularly dental curricula. This study aims to address these gaps by investigating the integration of LGBTQ+ content in a midwestern dental school curriculum.MethodsCurriculum mapping and focus group discussions were utilized to identify gaps and recommend integrating LGBTQ+ content into a predoctoral dental curriculum. The Doctor of Dental Surgery program was mapped to identify LGBTQ+ specific content relevant to cultural competency. A focus group of nine faculty members provided insights and recommendations, with data transcribed and analyzed for themes.ResultsOut of 121 courses, 28 included or had potential for LGBTQ+ content, with 16 already inclusive and 12 involving direct patient interaction. Integration varied, highest in the first year (28.6%) and lowest in the fourth year (5%). Focus group themes included the need for broader awareness and education about LGBTQ+ health, integrating topics into basic and behavioral science courses, and addressing practical clinical skills (e.g., using pronouns). Barriers included personal discomfort, lack of formal training, and potential conflicts with personal or religious beliefs.ConclusionsThis study highlighted the need for increased faculty awareness and enhanced inclusion of LGBTQ+ content throughout the predoctoral dental curriculum to prepare future practitioners for culturally competent care.