bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of the case mix experienced by chiropractic students during a clinical internship
Authors: Puhl Aaron A. , Reinhart Christine J , Injeyan H. Stephen , Tibbles Anthony 
Published: June 2017

Objective:
The primary objective of this study was to describe the case mix experienced by chiropractic students during their clinical internship at the Canadian Memorial Chiropractic College. Secondary objectives were to characterize teaching clinic patient populations, assess the similarity to previously published data for practicing chiropractors, and describe the treatment plans being recommended by interns.

Methods:
A prospective, observational study was conducted using a convenience sample of 24 chiropractic interns. Data were collected by interns using a standardized form that was completed for each new patient and each new complaint examined during the 1-year internship. Standardized forms included data regarding patient demographics, complaint characteristics, and treatment recommendations.

Results:
Data were included for 23 of 24 participating interns, who described 828 patients and a total of 948 unique complaint presentations. Overall, 60% of patients were female, 86% were 18 to 64 years old, and 23% were naive to chiropractic care. Of all presenting complaints, 93% were pain-based, 67% were chronic, 65% included spinal complaints, and 7% presented with red flags; individual interns' experiences were variable and are described. On average, treatment recommendations called for 9.4 visits and often included multimodal treatment approaches, most commonly soft-tissue therapies (91%), home-based active care (84%), and spine manipulation (70%).

Conclusions:
The findings of this study suggest that patients presenting to CMCC teaching clinics are similar to those reported previously to attend private chiropractic clinics. While all participating interns encountered multiple complex clinical cases, very few had experience with pediatric populations. This study adds to the few that detail the characteristics of patients attending chiropractic teaching clinics; to our knowledge it is the first to describe average case loads of chiropractic interns.
Ranking attention multiple instance learning for lymph node metastasis prediction on multicenter cervical cancer MRI
Authors: Jin Shan , Xu Hongming , Dong Yue , Wang Xiaofeng , Hao Xinyu , Qin Fengying , Wang Ranran , Cong Fengyu 
Published: October 2024

AbstractPurposeIn the current clinical diagnostic process, the gold standard for lymph node metastasis (LNM) diagnosis is histopathological examination following surgical lymphadenectomy. Developing a non‐invasive and preoperative method for predicting LNM is necessary and holds significant clinical importance.MethodsWe develop a ranking attention multiple instance learning (RA‐MIL) model that integrates convolutional neural networks (CNNs) and ranking attention pooling to diagnose LNM from T2 MRI. Our RA‐MIL model applies the CNNs to derive imaging features from 2D MRI slices and employs ranking attention pooling to create patient‐level feature representation for diagnostic classification. Based on the MIL and attention theory, informative regions of top‐ranking MRI slices from LNM‐positive patients are visualized to enhance the interpretability of automatic LNM prediction. This retrospective study collected 300 female patients with cervical cancer who underwent T2‐weighted magnetic resonance imaging (MRI) scanning and histopathological diagnosis from one hospital (289 patients) and one open‐source dataset (11 patients).ResultsOur RA‐MIL model delivers promising LNM prediction performance, achieving the area under the receiver operating characteristic curve (AUC) of 0.809 on the internal test set and 0.833 on the public dataset. Experiments show significant improvements in LNM status prediction using the proposed RA‐MIL model compared with other state‐of‐the‐art (SOTA) comparative deep learning models.ConclusionsThe developed RA‐MIL model has the potential to serve as a non‐invasive auxiliary tool for preoperative LNM prediction, offering visual interpretability regarding informative MRI slices and regions in LNM‐positive patients.
Considerations for widespread implementation of blood‐based biomarkers of Alzheimer's disease
Authors: Mielke Michelle M. , Anderson Matthew , Ashford J. Wesson , Jeromin Andreas , Lin Pei‐Jung , Rosen Allyson , Tyrone Jamie , VandeVrede Lawren , Willis Deanna , Hansson Oskar , Khachaturian Ara S. , Schindler Suzanne E. , Weiss Joan , Batrla Richard , Bozeat Sasha , Dwyer John R. , Holzapfel Drew , Jones Daryl Rhys , Murray James F. , Partrick Katherine A. , Scholler Emily , Vradenburg George , Young Dylan , Braunstein Joel B. , Burnham Samantha C. , de Oliveira Fabricio Ferreira , Hu Yan Helen , Mattke Soeren , Merali Zul , Monane Mark , Sabbagh Marwan Noel , Shobin Eli , Weiner Michael W. , Udeh‐Momoh Chinedu T. 
Published: October 2024

AbstractDiagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood‐based biomarkers (BBMs) for AD holds promise in enabling early detection of pathology and timely intervention. However, several critical considerations, such as the lack of consistent guidelines for assessing cognition, limited understanding of BBM test characteristics, insufficient evidence on BBM performance across diverse populations, and the ethical management of test results, must be addressed for widespread clinical implementation of BBMs in the United States. The Global CEO Initiative on Alzheimer's Disease BBM Workgroup convened to address these challenges and provide recommendations that underscore the importance of evidence‐based guidelines, improved training for health‐care professionals, patient empowerment through informed decision making, and the necessity of community‐based studies to understand BBM performance in real‐world populations. Multi‐stakeholder engagement is essential to implement these recommendations and ensure credible guidance and education are accessible to all stakeholders.
The origins of ADNI
Authors: Potter William Z. , Buckholtz Neil S. , Paul Steven M. 
Published: October 2024

AbstractA brief history of events surrounding the conceptualization and original implementation of the Alzheimer's Disease Neuroimaging Initiative (ADNI) as a public–private partnership (PPP) is provided from the perspective of three individuals directly involved from the outset. Potential barriers and how they were addressed are summarized, especially the decision to make all data freely accessible in real‐time. Decisions made at the beginning of ADNI are revisited in light of what has been learned over the past 20 years, especially the importance of the investment in cerebrospinal fluid (CSF) and blood measures and the commitment to data sharing. The key elements of ADNI's success from the authors’ perspective are also summarized.Highlights
Informal interactions among colleagues were the beginning of something big.
An NIH Director's personal decision on open data sharing has had perhaps the greatest impact of any single decision in the past several decades in terms of advancing clinical biomarker research.
After 20 years, blood‐based biomarkers of brain disease may soon take the place of brain imaging for purposes of diagnosis and drug development.
Synergistic Dual Activation Catalysis by Saccharin‐Based Ionic Liquids for Diastereoselective Synthesis of Ferrocene‐Appended Furopyranones, Furochromenones, and Benzofuranones
Authors: Srivastava Suman 
Published: October 2024

ABSTRACTA practical and straightforward strategy for the synthesis of ferrocene appended furopyranone, furochromenone, and benzofuranone via a metal‐free annulation reaction of imidazolium ylide with enone mediated by saccharin‐based ionic liquid has been reported. The mechanistic studies show an approach through synergistic dual activation of enone and imidazolium ylide via cation and anion of ionic liquid, respectively. This operationally simple protocol offers an easy and rapid access to a library of ferrocene appended furopyranone, furochromenone, and benzofuranone in moderate to good yields through the involvement of a six‐membered transition state.
The food industry supply chain: Synergy of environmental orientation and collaboration in implementing circularity
Authors: Varma Soumya , Patra Pradipta , Shankar Ravi 
Published: October 2024

AbstractCircularity within supply chains can be realized through the seamless integration of ecological concerns into business strategies, coupled with stakeholder collaboration throughout the supply chain. A study of a supply chain aiming for circularity was conducted in a real setting for a renowned multinational company in the food processing industry to explore how environmental orientation shapes collaborative practices. The model was applied to reveal the significance of the circular practices that supply chain members follow within the case company. The interpretive ranking process (IRP) was further applied to rank the stakeholders in the supply chain of this company. Results reveal that raw material suppliers, farmers, customers, and volunteers occupy a significant position in implementing circularity in this supply chain. It is essential to provide incentives to suppliers in order to encourage them to adopt practices that promote circular supply chains. Simultaneously, local communities need to play an active role in implementing effective waste management practices. This case study underscores the critical imperative of nurturing a pro‐environmental mindset while fostering synergetic collaboration among stakeholders, thereby paving the path towards achieving circularity.
Advancing interactive evidence maps: Visualising service commissioning options alongside research
Authors: Burchett Helen , Stansfield Claire , Macdowall Wendy , Richardson Michelle , Dick Samantha , Dickson Kelly , D'Souza Preethy , Khouja Claire , Kwan Irene , Raine Gary , Sowden Amanda , Sutcliffe Katy , Thomas James 
Published: October 2024

AbstractBackgroundInteractive evidence maps typically visualise characteristics of research evidence, and gaps in evidence, in a particular field.Aims, Materials & MethodsHere we present an example of an evidence map on digital drug and alcohol interventions in which the research evidence is supplemented with information about interventions in use (or available for use) in England. We used systematic review methods to identify systematic reviews of intervention effectiveness and an online survey to identify interventions in England.ResultsEighteen reviews and 40 interventions were included in the online map.Discussion & ConclusionTo our knowledge, this is the first map to juxtapose research and practice in this way. By extending evidence maps to include data on service provision, it becomes easier to see whether research and practice are aligned and where gaps in either evidence or practice (or both) exist.
Dietary quality and chemotherapy‐induced peripheral neuropathy in colon cancer
Authors: Compton Stephanie L. E. , Yang Shengping , Madere Joseph , Weltzien Erin K. , Caan Bette J. , Meyerhardt Jeffrey A. , Schmitz Kathryn H. , Brown Justin C. 
Published: October 2024

ABSTRACTBackgroundChemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting chemotoxicity caused by oxaliplatin. This study investigated the relationship between dietary quality and the development of moderate and/or severe CIPN in colon cancer survivors using data from the Focus on Reducing Dose‐Limiting Toxicities in Colon Cancer with Resistance Exercise trial (ClinicalTrials.gov identifier NCT03291951).MethodsDiet quality was collected using a 127‐item food‐frequency questionnaire and was scored using the Alternative Healthy Eating Index‐2010 (AHEI‐2010). CIPN was assessed with the Patient‐Reported Outcomes version of the Common Terminology Criteria for Adverse Events at each chemotherapy cycle. The association of dietary quality with time to the first moderate‐to‐severe (moderate‐severe) or severe event of CIPN was estimated using Cox proportional hazards models. Only participants who received oxaliplatin were included in this analysis (n = 132).ResultsSeventy‐four participants (56.1%) reported moderate‐severe CIPN. Higher dietary quality was associated with a significantly decreased risk of moderate‐severe CIPN (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.93–0.99) and severe CIPN (HR, 0.91; 95% CI, 0.85–0.98). Consumption of red and processed meat (HR, 1.78; 95% CI, 1.07–2.83) and sugar‐sweetened beverages (HR, 1.33; 95% CI, 1.10–1.59) was associated with an increased risk of moderate‐severe CIPN. Consumption of sugar‐sweetened beverages also was associated with an increased risk of severe CIPN (HR, 1.57; 95% CI, 1.14–2.18), whereas vegetable consumption was associated with a reduced risk of severe CIPN (HR, 0.29; 95% CI, 0.09–0.73).ConclusionsAmong patients with colon cancer who received oxaliplatin‐based chemotherapy, higher baseline dietary quality was associated with a reduced risk of moderate‐severe CIPN.
The optimal surgical treatment for canal‐wall‐up mastoidectomy of external auditory canal cholesteatoma
Authors: Pan Xiaodan , Gu Qin , Sun Xuan , Zhao Yahan , Liu Dongxin , Li Yi 
Published: October 2024

AbstractPurposeTo explore the optimal surgical excision treatment for external auditory canal (EAC) cholesteatoma involving the posterior wall and partial mastoid process.MethodsThis study included 115 inpatients (152 ears) diagnosed with EAC cholesteatoma involving posterior wall and partial mastoid from April 2022 to April 2024. Each patient underwent a canal‐wall‐up mastoidectomy, canaloplasty, and tympanoplasty. Preoperative clinical symptoms and hearing were compared with postoperative outcomes during follow‐ups.ResultsAll patients achieved a dry‐ear status and remained relapse‐free over the 0.5–2 years' follow‐ups. The most salient improvements were observed in hearing loss, oltagia, and aural fullness after the surgical intervention.ConclusionFor EAC cholesteatoma with the posterior canal wall and partial mastoid invasion, canal‐wall‐up mastoidectomy with reconstruction of the posterior canal wall is preferable, provided there are no severely extensive cholesteatomas present in the mastoid.
High malignancy rate in IgE‐deficient children
Authors: Uygun Dilara Fatma Kocacik , Uygun Vedat , Başaran Ayşen , Kocatepe Gaye , Kazlı Tuğba , Bingöl Ayşen 
Published: October 2024

AbstractRecent epidemiological studies have increasingly highlighted the antitumor efficacy of IgE owing to the increased malignancy rate in IgE‐deficient patients. The purpose of this study, the largest for children, was to determine whether malignant diagnoses in children are associated with IgE deficiency (IgE <2.5 kIU/L). A total of 6821 pediatric patients were reviewed, focusing on patients with IgE below 2.5 kIU/L (n = 599). The causes of IgE testing were evaluated by categorizing them as having cancer, allergies, suspected or diagnosed immunodeficiency, and other conditions. In all but one patient with malignancy, IgE levels were measured after the diagnosis of the disease. Malignancies were observed much more frequently in the low IgE group than in the normal group (10/599, 1.7% and 7/6222, 0.11%; OR = 15.07; 95% CI: 5.72–39.75; p <.0001). According to our analysis, 70% of the patients had leukemia/lymphoma, which is consistent with studies showing that hematologic malignancies are the most frequent cancers linked to IgE deficiency. No increase in the prevalence of cancer was observed in IgE‐deficient patients with suspected or diagnosed immunodeficiency. In conclusion, we observed a higher rate of previous malignancy (particularly hematologic cancer) in children with low serum IgE levels. Larger investigations would offer insightful information about the function of low IgE levels in predicting malignancy risk and improving the present diagnostic procedures.
Does scaffold enhancement show significant superiority over microfracture alone for treating knee chondral defects? A systematic review and meta‐analysis of randomised clinical trials
Authors: Pałka Karol , Kubisa Marta , Akbas Anna , Kubisa Michał , Dobrakowski Michał 
Published: October 2024

AbstractPurposeChondral and osteochondral lesions in the knee are common conditions that significantly impair individuals' well‐being and can lead to osteoarthritis, imposing substantial burdens on healthcare systems. The limited natural healing capacity of articular cartilage necessitates innovative treatment strategies. Microfracture (MF) is a widely used technique for knee chondral defects, but its long‐term efficacy is often inadequate. Although recent randomised controlled trials have compared microfractures with scaffold‐enhanced therapies, a comprehensive systematic review and meta‐analysis are lacking.MethodsAn extensive literature search was conducted in PubMed and EMBASE databases following PRISMA guidelines. Inclusion criteria focused on randomised controlled trials (RCTs) comparing microfractures alone to matrix‐induced chondrogenesis for knee chondral defects with at least a 12‐month follow‐up. Ten randomised controlled trials conducted between 2013 and 2024, enroling 378 patients, were included.ResultsThe meta‐analysis showed no significant superiority of scaffolds over MF (p > 0.05) in International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome, Visual Analog Scale, and Magnetic Resonance Observation of Cartilage Repair Tissue scores at 12 and 24 months. However, individual studies suggested the potential benefits of scaffolds, especially in long‐term outcomes. Clinical improvements from MF typically decline after 2–3 years, underscoring the need for long‐term follow‐up in future research.ConclusionOur meta‐analysis shows no significant difference between MF and MF with scaffold in treating knee cartilage defects, though some long‐term RCTs demonstrate statistically significant differences. The absence of a universally accepted algorithm for analysing knee chondral defects limits this study. Establishing reliable guidelines and standardised study protocols is essential to improve long‐term patient outcomes and the quality of future papers.Level of EvidenceLevel I
The impact of generative AI on the scholarly communications of early career researchers: An international, multi‐disciplinary study
Authors: Nicholas David , Swigon Marzena , Clark David , Abrizah Abdullah , Revez Jorge , Herman Eti , Rodríguez Bravo Blanca , Xu Jie , Watkinson Anthony 
Published: October 2024

AbstractThe Harbingers study of early career researchers (ECRs), their work life and scholarly communications, began by studying generational—Millennial—change (c.2016), then moved to pandemic change (c.2020) and is now investigating another potential agent of change: artificial intelligence (2024–). We report here on a substantial scoping pilot study that looks at the impact of AI on the scholarly communications of international ECRs and, extends this to the arts and humanities. It aims to fill the knowledge gap concerning ECRs whose millennial mindset may render them especially open to change and, as the research workhorses they are, very much in the frontline. The data was collected via in‐depth interviews in China, Malaysia, Poland, Portugal, Spain and (selectively) the United Kingdom/United States. The data show ECRs to be thinking, probing and, in some cases, experimenting with AI. There was a general acceptance that AI will be responsible for the growth of low‐quality scientific papers, which could lead to a decline in the quality of research. Scholarly integrity and ethics were a big concern with issues of authenticity, plagiarism, copyright and poor citation practices raised. The most widespread belief was AI would prove to be a transformative force and would exacerbate existing scholarly disparities and inequalities.
Field‐specific gold open access dynamics in the Chinese mainland: Overviews, disparities, and strategic insights
Authors: Chen Xinyi , Liu Zhiqiang 
Published: October 2024

AbstractGold Open Access (OA) journals are crucial for scholarly communication, highlighting the need for a thorough evaluation of their academic influence on different research fields. This study leverages the InCites platform to examine article‐level characteristics relating to 22 Essential Science Indicators (ESI) research fields, with a focus on the dynamics of gold OA articles, including gold OA uptake in the Chinese mainland and gold OA adoption in the domestic English‐language academic journal publishing of the Chinese mainland. The findings reveal that disparities in gold OA adoption across 22 ESI fields are more pronounced in the Chinese mainland compared with the world scenario. In the Chinese mainland, there is a significant polarization in gold OA publishing volumes across different ESI fields, particularly in Chemistry, Clinical Medicine, and Engineering. This study builds on the understanding of OA citation advantage (OACA) by incorporating gold OA publishing volume into a two‐dimensional framework, resulting in the development of a “distance” metric. It further categorizes gold OA citation effects into four quadrants: positive citation effects (quadrants A and B) and negative citation effects (quadrants C and D), based on category normalized citation impact (CNCI) and journal normalized citation impact (JNCI) indicators from the InCites database. The findings underscore the importance of developing tailored strategies to address field‐specific challenges and promote gold OA dynamics in the Chinese mainland; while prioritizing high‐quality gold OA journals is essential for fostering gold OA development in the rest of the world.
Isotopic signature of N2O produced during sulfur‐ and thiosulfate‐driven chemoautotrophic denitrification in freshwaters
Authors: Li Shengjie , Wang Shuo , Pang Yunmeng , Ji Guodong 
Published: October 2024

AbstractChemoautotrophic denitrification plays an important role in nitrogen removal and the formation of a greenhouse gas (N2O) in aquatic environments. Natural stable isotopes support the tracing of nitrogen sources and the identification of biogeochemical processes in field research. However, the isotopic characteristics of N2O produced during chemoautotrophic denitrification have not been investigated so far. In this study, we analyzed isotopic signatures of nitrate and N2O in sulfur‐ and thiosulfate‐dependent denitrifying enrichments obtained from freshwater lakes. Chemoautotrophic denitrification exhibited a nitrate isotope pattern similar to heterotrophic denitrification: the 18ε/15ε‐nitrate followed a ratio close to 1. However, chemoautotrophic denitrification produced N2O with lower δ15N, δ18O, and higher site preference (SP = δ15Nα‐δ15Nβ) values, compared to heterotrophic denitrification. The SP value, approximately 5.1‰, was characteristic in detecting chemoautotrophic denitrification driven by different sulfur forms. δ18O varied with specific electron donors, around 20‰ and 40‰ during sulfur‐ and thiosulfate‐dependent denitrification, respectively. The unique N2O isotope characteristics were likely regulated by nitric oxide reductases of Burkholderiaceae populations during sulfur‐dependent denitrification and Sulfurovum during thiosulfate‐dependent denitrification. These findings improve our understanding of N2O production processes and have important implications for predicting N2O emissions at a greater spatial and temporal resolution.