bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasar radiation dramatically transforms the gas in a merging companion galaxy
Authors: Balashev Sergei , Noterdaeme Pasquier , Gupta Neeraj , Krogager Jens-Kristian , Combes Francoise , Lopez Sebastian , Petitjean Patrick , Omont Alain , Srian Ranghunathan , Cuellar Rodrigo 
Published: September 2024

Abstract

Quasars, powered by gas accretion onto supermassive black holes at the centers of massive galaxies, rank among the Universe’s most energetic objects. Galaxy mergers have been proposed as pivotal events in fueling these supermassive black holes, igniting quasars into their active, luminous phase. The subsequent tremendous energy release is then anticipated to impact the quasar’s surroundings, influencing morphology, gas and star-formation properties, not only in the quasar host but also in companion galaxies. However, evidence supporting merging galaxies as primary feeding mechanism remains scarce and feedback effects on gas properties lack observational constraints, in particular on its small-scale structure. Here we unveil a major merging system at redshift 𝑧 ≈ 2.7 (approximately 2.5 billion years post Big Bang), and demonstrate that the gas properties in the merging companion galaxy are directly and dramatically altered by the quasar radiation. Our findings reveal that the quasar-host and companion galaxies, with centroids separated by only a few kiloparsecs and approaching each other at speed ≈ 550 km s−1, are both massive, form stars, and contain a substantial molecular mass. Yet, dusty molecular gas seen in absorption against the quasar nucleus is highly excited and confined within cloudlets of sizes <0.01 pc and densities ∼ 105 - 106 cm−3, several orders of magnitude more compact than those observed in non-quasar environments and approximately 105 times smaller than the scales attainable in emission. We infer that, wherever exposed to the quasar radiation, molecular gas is disrupted, leaving behind surviving dense clouds too small to give birth to new stars. Our results not only underscore the role of major galaxy mergers in triggering quasar and star-formation activity, but also reveal localized negative feedback as a profound alteration of internal gas structure which hampers star formation.
PIM Kinase Inhibitors as Novel Promising Therapeutic Scaffolds in Cancer Therapy
Authors: Karati Dipanjan , Saha Ankur , Roy Souvik , Mukherjee Swarupananda 
Published: September 2024

:
Cancer involves the uncontrolled, abnormal growth of cells and affects other tissues.
Kinase has an impact on proliferating the cells and causing cancer. For the purpose of treating cancer,
PIM kinase is a potential target. The pro-viral Integration site for moloney murine leukaemia
virus (PIM) kinases is responsible for the tumorigenesis, by phosphorylating the proteins that control
the cell cycle and cell proliferation. PIM-1, PIM-2, and PIM-3 are the three distinct isoforms of
PIM kinases. The JAK/STAT pathway is essential for controlling how PIM genes are expressed.
PIM kinase is also linked withPI3K/AKT/mTOR pathway in various types of cancers. The overexpression
of PIM kinase will cause cancer. Currently, there are significant efforts being made in
medication design and development to target its inhibition. A few small chemical inhibitors (E.g.,
SGI-1776, AZD1208, LGH447) that specifically target the PIM proteins' adenosine triphosphate
(ATP)-binding domain have been identified. PIM kinase antagonists have a remarkable effect on
different types of cancer. Despite conducting clinical trials on SGI-1776, the first PIM inhibitory
agent, was prematurely withdrawn, making it unable to generate concept evidence. On the other
hand, in recent years, it has aided in hastening the identification of multiple new PIM inhibitors.
Cyanopyridines and Pyrazolo[1,5-a]pyrimidinecan act as potent PIM kinase inhibitors for cancer
therapy. We explore the involvement of oncogenic transcription factor c-Mycandmi-RNA in relation
to PIM kinase. In this article, we highlight the oncogenic effects, and structural insights into PIM
kinase inhibitors for the treatment of cancer.
Design, Synthesis, Anti-Proliferative Effects, and Mechanistic Details of Fluorine-Containing Biguanide Derivatives with Various Carbon Rings
Authors: Xie Yijun , Zhang Qingtong , Xiao Di , Deng Meiling , Liu Yan , Duan Huaxin , Yang Xiaoping 
Published: September 2024

Introduction/Objective:
Biguanide derivatives are small molecules with promising antitumor
activity. However, the effect of different carbon rings at the end of one guanide group of
these compounds on anti-proliferation activity is unknown. Therefore, we synthesized novel fluorine-
containing biguanide compounds with various carbon rings, evaluated their anticancer activities,
and explored their anti-proliferative mechanisms.

Methods:
Guanidine derivatives containing trifluoromethoxy or 3,4-difluorophenyl with nine different
carbon rings were synthesized using established chemical methods. The phenyl side chain
was fixed to trifluoromethoxy or 3,4-difluorophenyl with changes in the number of cyclic aminocyclic
carbons. The effects of these derivatives were evaluated using MTT and clonogenic assays,
while the underlying mechanisms were investigated by analyzing protein expression levels via
western blotting.

Results:
This study analyzed the effects of new biguanide derivatives on cell growth in three different
cell lines: HepG2, Ovcar3, and T24. The results showed that T24 cells were the most sensitive
cell line to these biguanides. All biguanide derivatives significantly inhibited the growth of T24
cells, while compound 4b exhibited the strongest inhibition in all three cell lines by MTT assay.
The inhibitory effects of 4b were further confirmed using colony formation experiments. Western
blotting results indicated that the representative biguanide derivative, 4b, inhibited the EGFR signaling
pathway, thereby inhibiting tumor growth.

Conclusion:
1a-5a and 1b-4b, the cyclooctyl-containing 3,4-difluorophenyl biguanide analogs,
have demonstrated significant potential in developing novel anticancer drugs. The 3,4-
difluorophenyl biguanide containing cyclooctyl showed the best antitumor activity among the nine
derivatives. This finding offers a novel perspective in developing anticancer drugs and a further
improvement in biguanide activity in the future.
Epidemiology and Genetic Architecture of Type 2 Diabetes Mellitus in Geographically Different Indian Populations: A Review
Authors: Singh Jyotsna , Tripathi Vijay , Kant Rajiv , Lal Jonathan A. 
Published: September 2024

:
Type 2 Diabetes Mellitus (T2DM) has been a severe public health issue
worldwide for many years. The primary cause and risk factor of T2DM is hereditary and
complicated interaction between epigenetics. Identification and understanding of genetic
markers may help to detect, prevent, and manage T2DM. This review examined the effect
of single-gene and gene-gene interactions for predicting diabetes mellitus. Based on the
literature survey, common and unique Single Nucleotide Polymorphisms (SNPs) and
genes were explored in the Indian Populations, including PPARG, TCF7L2, KCNJ11,
CDKN2A, IGF2BP2, SLC30A8, HHEX and CDKAL1. Identifying common and specific
markers may help in risk prediction and early detection of T2DM. Future research and
Genome-wide association studies are also required to predict the gene-gene interaction,
generate large data sets for removing non-representative groups, and focus only on specific
marker-associated traits.
Short-term Uridine Treatment Alleviates Endoplasmic Reticulum Stress via Regulating Inflammation and Oxidative Stress in Lithium-Pilocarpine Model of Status Epilepticus
Authors: Aydin Birnur , Koc Cansu , Cansev Mehmet , Alkan Tulin 
Published: September 2024

Background:
Status Epilepticus (SE) leads to the development of epilepsy with the contribution of Endoplasmic Reticulum (ER) stress. Uridine, a pyrimidine
nucleoside, has been shown to have neuroprotective and antiepileptogenic effects in animal models. This study aimed to determine whether uridine
ameliorates ER stress and apoptosis following epileptogenic insult. Secondly, this study aimed to establish the effect of uridine on inflammatory
and oxidative stress parameters that contribute to ER stress.

Methods:
Status epilepticus was induced using lithium-pilocarpine in adult male Sprague-Dawley rats. Following SE termination, rats were treated with
uridine, 4-phenylbutyric acid (4-PBA), or saline twice daily for 48 h. Expressions of hippocampal glucose-regulated protein 78 (GRP78), Inositol-
Requiring Protein 1 (IRE1α), Protein kinase RNA-like Endoplasmic Reticulum Kinase (PERK), and C/EBP Homologous Protein (CHOP) were
determined by western blotting 48 h after SE. Uridine's effects on apoptosis, inflammation or oxidation were evaluated by analyses of cleaved
caspase-3 and poly(ADP-ribose) polymerase 1 (PARP1) protein expressions or pro-inflammatory cytokine levels or levels of oxidative stress
markers, respectively.

Results:
Expressions of all ER stress-related proteins significantly increased 48 h after SE. Uridine treatment markedly decreased GRP78, IRE1α, and
CHOP levels. A decrease in the PERK level was observed following the administration of 4-PBA; however, uridine had no effect. Cleaved
caspase-3 and PARP1 levels were increased in the SHAM group, while uridine and 4-PBA treatment effectively decreased their expressions.
Treatment with uridine significantly reduced Myeloperoxidase (MPO) and Malondialdehyde (MDA) levels while tending to increase Catalase
(CAT) and Glutathione Peroxidase (GPx) levels. Uridine treatment also significantly attenuated levels of TNF-α and IL-1β, the pro-inflammatory
cytokines, which increased 48 h post-SE.

Conclusion:
Our data indicate that uridine alleviates ER stress after SE. This effect may be attributed to the regulation of inflammation and oxidative stress.
Uridine shows promise as a potential preventive agent for epilepsy.
The Biological Effects and Mechanisms of Fisetin on Hepatotoxicity, Liver Injury, and Liver Fibrosis: A Systematic Review
Authors: Rahimian Ghorbanali , Heidari-Soureshjani Saeid , Kasiri Karamali 
Published: September 2024

Background:
Liver disease is a common cause of death worldwide.

Objectives:
This study aims to investigate the effects and mechanisms of Fisetin on hepatotoxicity,
liver injury, and liver fibrosis.

Methods:
We adhered to the PRISMA 2020 guidelines in this systematic review. Our search used
MeSH keywords encompassed Embase, PubMed, Web of Science, Scopus, and Cochrane Library for
articles published before March 2, 2024. Relevant data was extracted from the publications, meticulously
recorded in a standard form, and subsequently reviewed for outcomes and mechanisms.

Results:
Fisetin protects hepatocytes from oxidative stress by neutralizing free radicals (O2
−and
H2O2), reduces oxidative stress, prevents lipid peroxidation, and increases endogenous antioxidants.
It also reduces inflammation via lowering the production of tumor necrosis factor α (TNF-α), interleukins
(IL)1α, IL-6, IL-18, IL-1β suppressing nuclear factor kappa B (NF-κB) activation, and cyclooxygenase-
2 (COX-2), inducible nitric oxide synthase (iNOS) inhibition, reducing monocyte
chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor 1 (PAI-1), NLR family pyrin
domain-containing 3 (NLRP3) inflammasome and interferon-gamma (IFN‐γ). Moreover, it inhibited
apoptosis-modulated enzyme activity and detoxification enzymes via modulating the activity of cytochrome
P450 and Phase II detoxification enzymes. Fisetin prevented fibrosis by inhibiting the activation
of hepatic stellate cells (HSCs), attenuating extracellular matrix (ECM) remodeling-associated
genes, and suppressing transforming growth factor-β (TGF-β) signaling pathway and attenuating
collagen production. It decreased lipid accumulation and liver function tests.

Conclusion:
In vivo and in vitro studies indicated that Fisetin can enhance detoxification, attenuate
liver injury, and reduce fibrosis, which helps maintain liver health.
A Review of the Impact of the COVID-19 Pandemic on Lifestyle Behaviors
Authors: Mehraeen Esmaeil , Pashaei Ava , Mousavi Heydar , Yarmohammadi Soudabeh 
Published: September 2024

Introduction/Objective:
Although the COVID-19 pandemic primarily affected human
health and medicine, it has also had positive and negative impacts on various aspects of life. Hence,
this research aimed to explore the impact of the COVID-19 epidemic on lifestyle behaviors.

Methods:
The current research was a review conducted in 2023. PubMed, Scopus, and Google
Scholar databases were searched using standard keywords. Related articles were included in the
study after qualitative review and inclusion and exclusion criteria were applied, and data were extracted.

Results:
In the current research, 32 articles were included. Most reviewed studies referred to decreased
physical activity (78.12%), unhealthy dietary habits (65.62%), and sleep disturbance (56.25),
as the most affected lifestyle behaviors following the COVID-19 situation. Among the age groups,
the 18-89-year-old group reported more smoking and alcohol consumption than the other groups, and
the 1-21-year-old group reported the least smoking and alcohol consumption. Also, the age groups of
1 to 21 years and 18 to 69 years reported psychological problems, such as depression, anxiety, and
stress, compared to other age groups. There has been a relationship between overweight and reduced
physical activity, increased consumption of fast food and sweets, and also between decreased income
and increased mental problems, increased consumption of cigarettes and alcoholic beverages, and
decreased consumption of fruits and vegetables.

Conclusion:
The outbreak of the COVID-19 pandemic has had a significant impact on people's lifestyles,
which can negatively affect overall health and well-being. The combination of reduced physical
activity, unhealthy eating habits, and poor sleep has become a common consequence of the pandemic.
By recognizing the potential negative impacts of reduced physical activity, unhealthy eating
habits, and poor sleep, individuals can take steps to mitigate these effects.
Amplitude do rastreio e diagnóstico do câncer de mama no estado do Piauí e o impacto da pandemia da COVID-19
Authors: Silva Pedro Henrique dos Santos , Basso Fernandes Silva Franciele 
Published: September 2024

Introduction: The COVID-19 pandemic has brought about a new epidemiological reality worldwide that is responsible for altering the entire dynamics of addressing health issues globally. Cancer management policies were directly impacted, potentially leading to a decline in early case detection and a consequent increase in morbidity and mortality among patients with cancer. Objective: To analyze the impacts of the pandemic on breast cancer screening measures in the state of Piauí. Method: This epidemiological study used secondary data provided by the Department of Health Information of the Brazilian Unified Health System regarding the performance of mammograms and breast cancer diagnoses in the state of Piauí between 2017 and 2021. Results: Between 2017 and 2019, an average of 39,165 mammograms were performed annually, compared with an average of 22,367 exams in each year between 2020 and 2021. The data presented in this study indicate a significant decrease in the number of exams performed, associated with a decline in the absolute number of diagnoses, as well as delayed diagnoses. Conclusions: The scenario described in this study suggests the possibility of developing an epidemiological emergency related to breast cancer, both due to the structural incapacity of the state of Piauí to provide adequate assistance to patients and the increasing observation of more advanced cases. Therefore, we highlight the need for intensified efforts to strengthen breast cancer management and early diagnosis strategies in the state of Piauí.
Upaya Preventif UNICEF Dalam Pencegahan Kejahatan Seksual Pada Anak
Authors: Suryani Ita 
Published: September 2024

Upaya pencegahan kejahatan seksual pada anak tidak dapat menggandalkan semata-mata pada penindakan yang menjadi kewenangan institusi penegak hukum. Upaya pencegahan kejahatan seksual pada anak juga harus menjadi perhatian khusus bagi UNICEF dan keluarga. Sebagai salah satu elemen penting, keluarga diharapkan dapat berperan dalam memberikan pengetahuan dan pemahaman mengenai pencegahan kejahatan seksual pada anak. Tulisan ini menjelaskan mengenai upaya preventif yang dilakukan oleh UNICEF melalui video animasi pendidikan anak “Kisah si Geni”. Video tersebut memberikan edukasi kepada anak untuk mengetahui apa yang harus dilakukan agar terhindar dari kejahatan seksual. Pada video animasi bertajuk “kisah si Geni” yang di rilis oleh UNICEF diperuntukan bagi anak usia 3 s/d 12 tahun, yang didalamnya juga terdapat nomor telepon bantuan yang dapat dihubungi. Metode yang digunakan dalam penelitian ini yaitu metode studi kasus yaitu metode riset yang menggunakan berbagai sumber data yang bisa digunakan untuk meneliti, menguraikan dan menjelaskan secara komprehensif berbagai aspek individu, kelompok, suatu program, organisasi atau peristiwa secara sistematis. Kesimpulan menunjukkan bahwa video “Kisah si Geni” yang di rilis oleh UNICEF memberikan informasi dan pengetahuan kepada orang tua khususnya agar selalu dapat lebih respect dan memperhatikan anak-anak demi tercapainya tumbuh kembang anak yang lebih baik.
Pengaruh Tayangan Promosi Food Vlogger Chanel Youtube Mgdalenaf Terhadap Minat Beli Produk Kuliner
Authors: Prasetio Deni 
Published: September 2024

Penelitian ini bertujuan untuk menganalisis pengaruh tayangan promosi food vlogger chanel youtube mgdalenaf terhadap minat beli produk kuliner. Penelitian ini menggunakan teori SOR yaitu stimulus, organism, dan respon. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian survey. Penelitian survey di gunakan untuk menggambarkan atau menjelaskan sikap, pendapat, pikiran, dan prilaku terkini yang yang melingkupi suatu isu atau peristiwa tertentu dengan melibatkan sejumlah orang.Survey adalah metode riset dengan mengunakan kuesioner sebagai instrument pengumpulan datanya. Tujuanya untuk memperoleh informasi tentang sejumlah responden yang dianggap mewakili populasi tertentu. Dalam survey proses pengumpulan data dana analisis data sosial bersifat sangat terstruktur dan mendetail melalui kuesioner sebagai instrument utama untuk mendapatkan informasi dari sejumlah responden yang diasumsiakn mewakili populasi secara spesifik. Apabila Mahasiswa/i Mercu Buana Jurusan Advertising & Marcomm Angkatan 2016-2017 tidak memiliki kebutuhan mengkonsumsi produk kuliner, maka tayangan promosi food vlogger chanel youtube Mgdalenaf tidak akan berpengaruh terhadap minat beli produk kuliner Mahasiswa/i Mercu Buana
Strategi Komunikasi Promosi Iklan Produk Herbal Pada Media Sosial
Authors: Budiwidodo Andri , Rahmawati Yeni 
Published: September 2024

PT Mahkota Dewa Indonesia (MDI) yang merupakan perusahaan jamu herbal yang mengawali usaha sejak tahun 1999 dan resmi menjadi sebuah Perseroan Terbatas (PT) sejak 1 Januari 2003 yang sampai saat ini masih kosisten mengembangkan produknya dikategori herbal. PT Mahkota Dewa mau meningkatkan kesadaran produk Maducil. Dengan positioning perusahaan PT Mahkota Dewa Indonesia yang merupakan perusahaan pertama pengolah buah mahkota dewa menjadi suatu produk kesehatan tradisional dengan merek “Mahkota Dewa” dan logonya Ny. Ning Harmanto. Tantangan dan peluang bagi pelaku industri dalam membuat rancangan promosi iklan di media sosial. penulis dalam membuat rancangan strategi promosi Maducil menjadi karya skripsi aplikatif dengan membuat content planning untuk di aplikasikan di media sosial. Kata kunci: Strategi; Promosi; Iklan; Produk Herbal; Media sosial.
Learning Relationships Between Disparate Representations of Objects with Transformers and Contrastive Losses
Authors: Ramachandra Nesar , Wells Azton , Frontiere Nick , Habib Salman 
Published: September 2024

Large language models are moving into a multi-modal space covering text,
images, audio, and other media, yet scientific datasets possess features
that are not represented by this paradigm. In cosmology, for instance,
galaxies are embedded within dark matter-dominated collapsed objects,
termed halos. A galaxy can be described in many ways: star formation
history (SFH) characterizing the evolution of stellar content,
magnitudes describing luminosity across different wavelengths (MAG),
images, or matter distribution of the hosting halo. Despite their
differences, these descriptions represent the same cosmological
object. We propose the Object Foundation Model (OFM) to learn disparate
representations of objects in scientific domains. OFM learns the general
underlying representation of sparse and indeterminate data and
facilitates robust predictions on diverse inputs. Unlike traditional
deep learning with architecture-specific predictions, the OFM
predictions are requested via a language-based key that varies with the
user query.
RESPON PETERNAK PLASMA TERHADAP PROGRAM BERTANI UNTUK NEGERI (Studi Kasus pada Peternak Plasma Ayam Broiler di Kecamatan Susukan Kabupaten Semarang Provinsi Jawa Tengah)
Authors: Heryadi Fitria Roselinda , Mauludin Mochammad Ali , Sulaeman Munandar 
Published: September 2024

Program Bertani Untuk Negeri (BUN) yang diadakan oleh Yayasan EduFarmers International yang berkerja sama dengan kemendikbudristek menjawab permasalahan peternak mengenai manajemen pemeliharaan ayam broiler. Penelitian bertujuan untuk mengetahui mekanisme, respon peternak plasma, dan dinamika perubahan peternak plasma dengan adanya program BUN. Penelitian dilakukan kepada Peternak Plasma PT Ciomas Adisatwa yang tergabung dalam Program BUN di Kecamatan Susukan, Kabupaten Semarang, Provinsi Jawa Tengah pada tanggal 15 September 2022 – 30 Oktober 2022 dengan metode studi kasus melibatkan sepuluh informan yang terdiri dari pihak Yayasan EduFarmers International, para peternak, dan buruh peternak. Hasilnya menunjukkan program BUN menerapkan lima fungsi manajemen yakni perencanaan model rasional, pengorganisasian, pengarahan secara tertulis dan lisan, pengawasan dilaksanakan secara rutin, dan evaluasinya yakni meningkatnya pendapatan peternak dan peserta yang mengikuti program BUN, respon peternak plasma terhadap program BUN menghasilkan respon kognitif 91,84% positif, respon afektif 85,71% positif, dan respon psikmotorik 78,57% positif, dan dinamika perubahan yang dialami peternak yakni memberikan suatu perubahan baik, yakni dari segi teknis maupun non teknis yang dialami masing-masing peternak.
REFLEKSI IDEOLOGI DALAM TINDAK TUTUR ILOKUSI PADA PIDATO VIKTOR ORBAN
Authors: Harmia Citra Dewi 
Published: September 2024

Pidato politik kerap merepresentasikan ideologi atau sikap tertentu dari partai atau golongan tersebut terhadap permasalahan yang terdapat di berbagai sektor publik. Analisis terhadap pidato politik menjadi krusial sebagai alat untuk memahami makna dari wacana yang disampaikan. Artikel ini bertujuan untuk mengidentifikasi jenis dan fungsi tindak tutur ilokusi yang ditunjukkan Viktor Orban melalui tuturan dalam pidatonya pada pembukaan Conservative Political Action Conference (CPAC) 2022 di Texas, Amerika Serikat. Penelitian ini menggunakan metodologi campuran kuantitatif-kualitatif dengan pendekatan interpretasi studi kasus dan data temuan dalam pidato Viktor Orban. Sumber data berupa tuturan dalam bahasa Inggris yang ditranskripsikan dari video rekaman pidato Viktor Orban yang diunggah di kanal Youtube VOKS.News. Data dianalisis dengan mengidentifikasi dan mengelompokkan jenis tindak tutur ilokusi yang muncul, kemudian dilakukan analisis terhadap fungsi tindak tutur tersebut dalam konteks pidato. Hasil analisis menunjukkan adanya representasi ideologi dan sikap dari Viktor Orban terhadap isu imigran yang dicerminkan melalui tindak tutur asertif, ekspresif, dan direktif. Tindak tutur asertif ditemukan sebagai jenis tindak tutur yang mendominasi pidato Viktor Orban, menunjukkan konstruksi ideologi Viktor Orban dibangun melalui pernyataan dan klaim yang bersifat persuasif terhadap isu imigran dan nasionalisme.