bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einfluss einer Betonbeschichtung auf die Mechanismen der Bewehrungskorrosion in gerissenem Stahlbeton
Authors: Keßler Sylvia , Hiemer Florian , Gehlen Christoph 
Published: April 2017

AbstractDie Dauerhaftigkeit von chloridexponierten Stahlbetonbauwerken kann durch Rissbildung erheblich reduziert werden. Durch die Risse können Chloride vergleichsweise rasch zur Bewehrung gelangen und Bewehrungskorrosion initiieren. Daher wird in einschlägigen Regelwerken [1, 2] vorgegeben, bei besonders gefährdeten Bauwerken wie Parkdecks dem Eindringen von Chloriden durch zusätzliche Maßnahmen dauerhaft entgegenzuwirken. Das DBV‐Merkblatt „Parkhäuser und Tiefgaragen” [3] enthält verschiedene Entwurfsgrundsätze und Ausführungsvarianten zur Sicherstellung der Dauerhaftigkeit. Eine Variante sieht vor, gemäß dem Instandsetzungsprinzip W‐Cl nach RL SIB [4] bzw. dem Verfahren 8.3 nach DIN EN 1504‐9 [5] die Betonoberfläche mit einem rissüberbrückenden Oberflächenschutzsystem (OS) nach abgeschlossener Rissbildung zu verschließen, um eine weitere Chlorid‐ und Feuchtezufuhr zu verhindern und damit den elektrischen Widerstand des Betons zu erhöhen.In einem umfangreichen Experimentalprogramm konnte für die Situation „bewehrungskreuzende Biegerisse” gezeigt werden, dass nach zeitweiser Chloridexposition, wie sie in Parkhäusern über eine Winterperiode im unbeschichteten Zustand zu erwarten ist, durch eine Betonbeschichtung zuvor bereits aktivierte Makroelementströme maßgeblich reduziert bis vollständig gestoppt wurden. Der Erfolg dieser Maßnahme beruht auf dem Anstieg des anodischen Polarisationswiderstands aufgrund von Deckschichtbildung und/oder unzureichendem Nachschub von Chloriden. Der Einfluss der Erhöhung des Elektrolytwiderstands auf das Makrokorrosionselement durch Austrocknung des Betons ist vernachlässigbar. Noch nicht abschließend geklärt ist die Frage nach dem höchstzulässigen Chloridgehalt, der im Beton verbleiben darf, damit auch nach einer Beschichtung keine Bewehrungskorrosion mit standsicherheitsrelevanten Querschnittsverlusten initiiert bzw. aufrecht erhalten wird.
Interaction between azo dye Acid Red 14 and pepsin by multispectral methods and docking studies
Authors: Zhao Ludan , Guo Ronghui , Sun Qiaomei , Lan Jianwu , Li Hui 
Published: April 2017

AbstractThe interaction of synthetic azo dye Acid Red 14 with pepsin was studied by fluorescence spectroscopy, UV–vis spectroscopy, circular dichroism and molecular docking. Results from the fluorescence spectroscopy show that Acid Red 14 has a strong capability to quench the intrinsic fluorescence of pepsin with static quenching. Binding constant, number of the binding sites and thermodynamic parameters were measured at different temperatures. The result indicates that Acid Red 14 interact with pepsin spontaneously by hydrogen bonding and van der Waals interactions. Three‐dimensional fluorescence spectra and circular dichroism spectra reveal that Acid Red 14 could slightly change the structure of pepsin. The hydrogen bond is formed between Acid Red 14 and Tyr‐189 and Thr‐218 residues of pepsin. Furthermore, the binding between Acid Red 14 and pepsin inhibits pepsin activity. The study can provide a way to analyze the biological safety of Acid Red 14 on digestive proteases or other proteins.
Randomized clinical trial of autologous skin cell suspension for accelerating re-epithelialization of split-thickness donor sites
Authors: Hu Z , Guo D , Liu P , Cao X , Li S , Zhu J , Tang B 
Published: April 2017

Abstract

Background
Split-thickness skin graft (STSG) is used frequently, but may result in complications at the donor site. Rapid healing of donor-site wounds is critical to relieving morbidity. This study investigated whether autologous skin cell suspension could improve healing of STSG donor-site wounds.

Methods
Between September 2014 and February 2016, patients requiring STSGs were randomized to receive autologous skin cell suspension plus hydrocolloid dressings (experimental group) or hydrocolloid dressings alone (control group) for the donor site. The primary outcome was time to complete re-epithelialization. Secondary outcomes included pain and itching scores measured on a visual analogue scale, and adverse events. Patients were followed for 12 weeks to evaluate quality of healing. Analysis was by intention to treat.

Results
Some 106 patients were included, 53 in each group. Median time to complete re-epithelialization was 9·0 (95 per cent c.i. 8·3 to 9·7) days in the experimental group, compared with 13·0 (12·4 to 13·6) days in the control group (P &lt; 0·001). Overall postoperative pain and itching scores were similar in both groups. No between-group differences in treatment-related complications were observed. Both patients and observers were more satisfied with healing quality after autologous skin cell suspension had been used.

Conclusion
The use of autologous skin cell suspension with hydrocolloid dressings accelerated epithelialization and improved healing quality of the donor site compared with hydrocolloid dressings alone. Registration number: UMIN000015000 (http://www.umin.ac.jp/ctr).
Survival analysis of the CEAwatch multicentre clustered randomized trial
Authors: Verberne C J , Zhan Z , van den Heuvel E R , Oppers F , de Jong A M , Grossmann I , Klaase J M , de Bock G H , Wiggers T 
Published: April 2017

Abstract

Background
The CEAwatch randomized trial showed that follow-up with intensive carcinoembryonic antigen (CEA) monitoring (CEAwatch protocol) was better than care as usual (CAU) for early postoperative detection of colorectal cancer recurrence. The aim of this study was to calculate overall survival (OS) and disease-specific survival (DSS).

Methods
For all patients with recurrence, OS and DSS were compared between patients detected by the CEAwatch protocol versus CAU, and by the method of detection of recurrence, using Cox regression models.

Results
Some 238 patients with recurrence were analysed (7·5 per cent); a total of 108 recurrences were detected by CEA blood test, 64 (55·2 per cent) within the CEAwatch protocol and 44 (41·9 per cent) in the CAU group (P = 0·007). Only 16 recurrences (13·8 per cent) were detected by patient self-report in the CEAwatch group, compared with 33 (31·4 per cent) in the CAU group. There was no significant improvement in either OS or DSS with the CEAwatch protocol compared with CAU : hazard ratio 0·73 (95 per cent 0·46 to 1·17) and 0·78 (0·48 to 1·28) respectively. There were no differences in survival when recurrence was detected by CT versus CEA measurement, but both of these methods yielded better survival outcomes than detection by patient self-report.

Conclusion
There was no direct survival benefit in favour of the intensive programme, but the CEAwatch protocol led to a higher proportion of recurrences being detected by CEA -based blood test and reduced the number detected by patient self-report. This is important because detection of recurrence by blood test was associated with significantly better survival than patient self-report, indirectly supporting use of the CEAwatch protocol.
Business Model Innovation for Sustainability: Towards a Unified Perspective for Creation of Sustainable Business Models
Authors: Evans Steve , Vladimirova Doroteya , Holgado Maria , Van Fossen Kirsten , Yang Miying , Silva Elisabete A. , Barlow Claire Y. 
Published: April 2017

AbstractBusiness model innovation has seen a recent surge in academic research and business practice. Changes to business models are recognized as a fundamental approach to realize innovations for sustainability. However, little is known about the successful adoption of sustainable business models (SBMs). The purpose of this paper is to develop a unified theoretical perspective for understanding business model innovations that lead to better organizational economic, environmental and social performance. The paper examines bodies of literature on business model innovation, sustainability innovation, networks theory, stakeholder theory and product–service systems. We develop five propositions that support the creation of SBMs in a unified perspective, which lays a foundation to support organizations in investigating and experimenting with alternative new business models. This article contributes to the emerging field of SBMs, which embed economic, environmental and social flows of value that are created, delivered and captured in a value network. It highlights gaps for addressing the challenges of business model innovation for sustainability and suggests avenues for future research. © 2017 The Authors. Business Strategy and the Environment published by ERP Environment and John Wiley & Sons Ltd
StrandAdvantage test for early‐line and advanced‐stage treatment decisions in solid tumors
Authors: Sen Manimala , Katragadda Shanmukh , Ravichandran Aarthi , Deshpande Gouri , Parulekar Minothi , Nayanala Swetha , Vittal Vikram , Shen Weiming , Phooi Nee Yong Melanie , Jacob Jemima , Parchuru Sravanthi , Dhanuskodi Kalpana , Eyring Kenneth , Agrawal Pooja , Agarwal Smita , Shanmugam Ashwini , Gupta Satish , Vishwanath Divya , Kumari Kiran , Hariharan Arun K. , Balaji Sai A. , Liang Qiaoling , Robolledo Belen , Gauribidanur Raghavendrachar Vijayashree , Oomer Farooque Mohammed , Buresh Cary J. , Ramamoorthy Preveen , Bahadur Urvashi , Subramanian Kalyanasundaram , Hariharan Ramesh , Veeramachaneni Vamsi , Sankaran Satish , Gupta Vaijayanti 
Published: April 2017

AbstractComprehensive genetic profiling of tumors using next‐generation sequencing (NGS) is gaining acceptance for guiding treatment decisions in cancer care. We designed a cancer profiling test combining both deep sequencing and immunohistochemistry (IHC) of relevant cancer targets to aid therapy choices in both standard‐of‐care (SOC) and advanced‐stage treatments for solid tumors. The SOC report is provided in a short turnaround time for four tumors, namely lung, breast, colon, and melanoma, followed by an investigational report. For other tumor types, an investigational report is provided. The NGS assay reports single‐nucleotide variants (SNVs), copy number variations (CNVs), and translocations in 152 cancer‐related genes. The tissue‐specific IHC tests include routine and less common markers associated with drugs used in SOC settings. We describe the standardization, validation, and clinical utility of the StrandAdvantage test (SA test) using more than 250 solid tumor formalin‐fixed paraffin‐embedded (FFPE) samples and control cell line samples. The NGS test showed high reproducibility and accuracy of >99%. The test provided relevant clinical information for SOC treatment as well as more information related to investigational options and clinical trials for >95% of advanced‐stage patients. In conclusion, the SA test comprising a robust and accurate NGS assay combined with clinically relevant IHC tests can detect somatic changes of clinical significance for strategic cancer management in all the stages.
The prognostic value of simultaneous tumor and serum RAS/RAF mutations in localized colon cancer
Authors: Thomsen Caroline Emilie B. , Appelt Ane Lindegaard , Andersen Rikke Fredslund , Lindebjerg Jan , Jensen Lars Henrik , Jakobsen Anders 
Published: April 2017

AbstractThe impact of RAS/RAF mutations in localized colon cancer needs clarification. Based on analysis of tumor‐specific DNA, this study aimed at elucidating the prognostic influence of mutational status in tumor and serum using an extended panel of mutations.The study retrospectively included 294 patients with curatively resected stage I–III adenocarcinoma of the colon. Mutations in tumor and serum were determined at time of surgery. Analyses were performed with droplet digital PCR technology. Hazard ratio (HR) for the association between mutational status and survival was estimated in multivariate analysis taking known prognostic factors into account.Mutational status in tumor did not on its own have significant prognostic impact (P = 0.22). Patients with a RAS mutation simultaneously in tumor and serum had a significantly worse prognosis, overall survival (OS) (HR = 2.30, 95% CI = 1.27–4.15, P = 0.0057), and disease‐free survival (DFS) (HR = 2.18, 95%CI = 1.26–3.77, P = 0.0053). BRAF mutation in the serum and proficient mismatch repair (pMMR) protein in tumor also indicated significantly worse prognosis, OS (HR = 3.45, 95% CI = 1.52–7.85, P = 0.0032) and DFS (HR = 3.61, 95% CI = 1.70–7.67, P = 0.0008). In conclusion, RAS mutations in serum, and BRAF mutation in serum combined with pMMR in tumor were strong independent prognostic factors in patients with RAS/RAF mutated tumors.
Cancer risk in patients with hepatitis C virus infection: a population‐based study in Sweden
Authors: Liu Xiangdong , Chen Yanqing , Wang Youxin , Dong Xiaohua , Wang Junming , Tang Jianhua , Sundquist Kristina , Sundquist Jan , Ji Jianguang 
Published: April 2017

AbstractIncreased risks of certain cancers have been observed in patients with hepatitis C virus (HCV) infection. However, data on other cancer sites/types are lacking. We analyzed systematically the risk of developing 35 common cancers in patients with HCV infection using a nationwide Swedish database. Patients with HCV infection were identified from the Swedish Hospital Inpatient and Outpatient Register and Primary Health Care Database, and followed until the diagnosis of cancer. Standardized incidence ratios (SIRs) were calculated for subsequent 35 common cancer sites/types between 1990 and 2010 in patients with HCV infection in Sweden. Increased risks were recorded for six cancers. The highest SIR was seen for liver cancer (36.67; 95% CI: 33.20–40.40). The decreased risk was for prostate cancer (0.73; 95% CI: 0.59–0.90) and melanoma (0.50; 95% CI: 0.30–0.79). A significant sex‐difference for cancer was observed only for liver cancer (40.72; 95% CI: 36.36–45.45 for men and 27.21; 95% CI: 21.90–33.41 for women). Also, increased SIRs were noted only for liver cancer during the entire period of follow‐up. HCV infection was associated with an increased incidence of liver cancer and additionally five other types of cancer. Active surveillance of other cancers may be needed in order to be diagnosed at an earlier stage.
New Resorcinol Derivatives from a Sponge‐Derived Fungus Hansfordia sinuosae
Authors: Wu Zehong , Li Yuan , Liu Dong , Ma Min , Chen Jianliang , Lin Wenhan 
Published: April 2017

Ten new resorcinol derivatives named hansfordiols A – J (1 – 10) were isolated from the fermentation broth of the sponge‐derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT‐IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher's method and their specific optical rotation. The structures of compounds 8 – 10 were featured with various chlorination at aromatic rings. Their antioxidant activities on ABTS, cytotoxicity on the HCT‐8, Bel‐7402, BGC‐823, A549, and A2780 cell lines, and antibacterial activities were evaluated.
Adult criminality among former residential school adolescents
Authors: Manninen Marko , Suvisaari Jaana , Marola Niko , Aaltonen Mikko 
Published: April 2017

AbstractBackgroundThere is evidence from around the world that disruptive behaviour during adolescence is associated with increased risk of later criminality. Outcomes for young people placed in the Finnish residential school because of severe conduct problems are not known.AimsOur aims were to investigate criminality after leaving a residential school placement during adolescence, and to compare trends in criminality between four successive graduate cohorts (1991, 1996, 2001 and 2006).MethodsWe used official records to study complete national cohort of all 861 people who had been resident in the Finnish residential school system on the last day of each of the years 1991, 1996, 2001 and 2006. They were compared with 4255 matched general population controls. The follow‐up time was up to 20 years.ResultsTwo‐thirds (66%) of all residential school graduates (N = 566: 448/78% men, 118/41% women) had at least one criminal conviction in adulthood, a 13‐fold elevation over the general population rate. The most prevalent crime categories were violence (N = 409, 48%: 331/58% men, 78/27% women) and property crimes (N = 405: 47%: 346/60% men, 51/21% women). The risk of violent crime was 18 times that among controls; 13 of residential school males (2.3%) had a homicide conviction. Once adult, the risk of offending decreased with age. There was a significant trend for improvement in offending rates between the earliest and latest residential school cohorts.ConclusionsThe risk of committing crimes after a residential school placement is sufficiently elevated that alternative strategies, perhaps particularly longer‐term post‐release supervision and aftercare, should be considered. Indications of lower crime rates in later cohorts suggest that some positive changes to the school regime and/or aftercare may have been made already. Copyright © 2017 John Wiley & Sons, Ltd.
Dynamics of Bulk Oxygen in the Selective Oxidation of Acrolein
Authors: Heid Maurice , Knoche Stefan , Gora Niklas , Ohlig Dominik , Drochner Alfons , Etzold Bastian J. M. , Vogel Herbert 
Published: April 2017

AbstractThe gas‐phase oxidation of acrolein to acrylic acid on a hydrothermally prepared mixed oxide catalyst was investigated by steady‐state isotopic transient kinetic analysis (SSIKTA) as well as different types of concentration‐programmed techniques (CPR‐pulse, CPO) under in situ or process‐relevant conditions. Balancing the amounts of active oxygen gives an overview of the quantities of participating bulk oxygen species. The dynamics of bulk oxygen lead to re‐oxidation processes on the catalyst surface and thus influence the selectivity pattern of the network of acrolein oxidation. Furthermore, the bulk dynamics are activated by temperature.
Synthesis and Catalysis of Redox‐Active Bis(imino)acenaphthene (BIAN) Iron Complexes
Authors: Villa Matteo , Miesel Dominique , Hildebrandt Alexander , Ragaini Fabio , Schaarschmidt Dieter , Jacobi von Wangelin Axel 
Published: April 2017

AbstractReactions of various substituted bis(imino)acenaphthenes (R‐BIANs) with FeCl2(thf)1.5 afforded the tetrahedral complexes (R‐BIAN)FeCl2 (2) from bulky α‐diimines and the octahedral complexes [Fe(R‐BIAN)3][FeCl4]2 (3) from less bulky ligands. The driving force for the formation of complexes 3 is the high ligand‐field stabilization of the low‐spin FeII center. The two sets of complexes exhibit distinct charge‐transfer band intensities and redox activities. (R‐BIAN)FeCl2 complexes showed reversible ligand‐centered reductions at −0.9 V (vs. FcH/FcH+; FcH: ferrocene); further reduction led to decomposition. Irreversible oxidations were observed at 0.2 and 0.4 V, associated with a reduction at −0.4 V, as well as a ligand‐centered redox event at 1.0 V. First applications of the Fe(BIAN) complexes to hydrogenations of alkenes indicated good catalytic activity under mild conditions.
Mechanistic Insights into the Catalytic Hydrolysis of Ammonia Borane with Proton‐Responsive Iridium Complexes: an Experimental and Theoretical Study
Authors: Wang Wan‐Hui , Tang Hui‐Peng , Lu Wen‐Duo , Li Yang , Bao Ming , Himeda Yuichiro 
Published: April 2017

AbstractFor the homogeneous catalytic hydrolysis of ammonia borane (AB), a series of water‐soluble proton‐responsive iridium complexes bearing hydroxyl groups were utilized. Among the examined catalysts, [Cp*Ir(6,6′‐(OH)2‐bpy)(OH2)]SO4 exhibited the best catalytic performance in AB aqueous solution. Results obtained from experimental and theoretical studies revealed that hydrolysis of AB is assisted by synergistic effects between the pendent hydroxyl groups and the metal center.
Highly Stable Intermetallic FeSn2‐Graphite Composite Anode for Sodium‐Ion Batteries
Authors: Edison Eldho , Ling Wong Chui , Aravindan Vanchiappan , Madhavi Srinivasan 
Published: April 2017

AbstractThe development of anodes with high capacity, long cycle life and good rate capability is essential to expedite the commercialization of sodium‐ion batteries for practical applications, including grid storage and electric vehicles (EV). Herein, we report the facile solvothermal synthesis of nanostructured iron distannide (FeSn2) intermetallic particles as an alloy‐type anode and the improvement of its cycle life by fabricating FeSn2‐graphite composites by a ball‐milling process. The influence of graphite concentration on the sodium storage properties is studied. The composite anode delivered over 400 mAh g−1 sodiation capacity over 200 cycles at a specific current of 100 mA g−1. In addition, the composite anode exhibited excellent rate performance at higher current rates. This result would certainly pave the way for the development of high‐performance anodes that would realize low‐cost sodium‐ion batteries with a longer calendar life.
Au Nanochains Anchored on 3D Polyaniline/Reduced Graphene Oxide Nanocomposites as a High‐Performance Catalyst for Ethanol Electrooxidation
Authors: Zhang Ke , Shi Yuting , Li Shumin , Wang Caiqin , Yan Bo , Xu Hui , Wang Jin , Guo Jun , Du Yukou 
Published: April 2017

AbstractA nanocomposite containing Au, polyaniline (PANI) and reduced graphene oxide (RGO) has been synthesized by a two‐step method. The PANI can intermix with graphene to build a three‐dimensional (3D) structure, which is beneficial for uniform dispersion of Au networks with a mean diameter of 5.6 nm. In addition to its role as the support of Au, the presence of PANI is also favorable for avoiding the heavy agglomeration of graphene when the reduction occurs. Additionally, the introduction of graphene can not only boost the connections with PANI, but also accelerate the electron transfer between the electrolyte solution and catalysts. Electrochemical tests indicate that the Au/PANI/RGO hybrid exhibits high catalytic activity and stability for ethanol electrooxidation in alkaline conditions. The superior performance can be ascribed to the uniform dispersion of the Au nanocatalyst on the PANI/RGO support with a particular 3D structure, resulting in an increase of the electrochemically active surface area together with a synergic effect between the PANI, graphene and Au.
Peroxotantalate‐Based Ionic Liquid Catalyzed Epoxidation of Allylic Alcohols with Hydrogen Peroxide
Authors: Ma Wenbao , Chen Chen , Kong Kang , Dong Qifeng , Li Kun , Yuan Mingming , Li Difan , Hou Zhenshan 
Published: April 2017

AbstractThe efficient and environmentally benign epoxidation of allylic alcohols has been attained by using new kinds of monomeric peroxotantalate anion‐functionalized ionic liquids (ILs=[P4,4,4,n]3[Ta(O)3(η‐O2)], P4,4,4,n=quaternary phosphonium cation, n=4, 8, and 14), which have been developed and their structures determined accordingly. This work revealed the parent anions of the ILs underwent structural transformation in the presence of H2O2. The formed active species exhibited excellent catalytic activity, with a turnover frequency for [P4,4,4,4]3[Ta(O)3(η‐O2)] of up to 285 h−1, and satisfactory recyclability in the epoxidation of various allylic alcohols under very mild conditions by using only one equivalent of hydrogen peroxide as an oxidant. NMR studies showed the reaction was facilitated through a hydrogen‐bonding mechanism, in which the peroxo group (O–O) of the peroxotantalate anion served as the hydrogen‐bond acceptor and hydroxyl group in the allylic alcohols served as the hydrogen‐bond donor. This work demonstrates that simple monomeric peroxotantalates can catalyze epoxidation of allylic alcohols efficiently.