bluuebunny/crossref_metadata_2025_split huggingface dataset:
STONE SPACE OF CYLINDRIC ALGEBRAS AND TOPOLOGICAL MODEL SPACES
Authors: PINTER CHARLES C. 
Published: September 2016

AbstractThe Stone representation theorem was a milestone for the understanding of Boolean algebras. From Stone’s theorem, every Boolean algebra is representable as a field of sets with a topological structure. By means of this, the structural elements of any Boolean algebra, as well as the relations between them, are represented geometrically and can be clearly visualized. It is no different for cylindric algebras: Suppose that ${\frak A}$ is a cylindric algebra and ${\cal S}$ is the Stone space of its Boolean part. (Among the elements of the Boolean part are the diagonal elements.) It is known that with nothing more than a family of equivalence relations on ${\cal S}$ to represent quantifiers, ${\cal S}$ represents the full cylindric structure just as the Stone space alone represents the Boolean structure. ${\cal S}$ with this structure is called a cylindric space.Many assertions about cylindric algebras can be stated in terms of elementary topological properties of ${\cal S}$. Moreover, points of ${\cal S}$ may be construed as models, and on that construal ${\cal S}$ is called a model space. Certain relations between points on this space turn out to be morphisms between models, and the space of models with these relations hints at the possibility of an “abstract” model theory. With these ideas, a point-set version of model theory is proposed, in the spirit of pointless topology or category theory, in which the central insight is to treat the semantic objects (models) homologously with the corresponding syntactic objects so they reside together in the same space.It is shown that there is a new, purely algebraic way of introducing constants in cylindric algebras, leading to a simplified proof of the representation theorem for locally finite cylindric algebras. Simple rich algebras emerge as homomorphic images of cylindric algebras. The topological version of this theorem is especially interesting: The Stone space of every locally finite cylindric algebra ${\frak A}$ can be partitioned into subspaces which are the Stone spaces of all the simple rich homomorphic images of ${\frak A}$. Each of these images completely determines a model of ${\frak A}$, and all denumerable models of ${\frak A}$ appear in this representation.The Stone space ${\cal S}$ of every cylindric algebra can likewise be partitioned into closed sets which are duals of all the types in ${\frak A}$. This fact yields new insights into miscellaneous results in the model theory of saturated models.
Casting wider nets for anxiety and depression: disability-driven cross-diagnostic subtypes in a large cohort
Authors: Wanders R. B. K. , van Loo H. M. , Vermunt J. K. , Meijer R. R. , Hartman C. A. , Schoevers R. A. , Wardenaar K. J. , de Jonge P. 
Published: September 2016

BackgroundIn search of empirical classifications of depression and anxiety, most subtyping studies focus solely on symptoms and do so within a single disorder. This study aimed to identify and validate cross-diagnostic subtypes by simultaneously considering symptoms of depression and anxiety, and disability measures.MethodA large cohort of adults (Lifelines, n = 73 403) had a full assessment of 16 symptoms of mood and anxiety disorders, and measurement of physical, social and occupational disability. The best-fitting subtyping model was identified by comparing different hybrid mixture models with and without disability covariates on fit criteria in an independent test sample. The best model's classes were compared across a range of external variables.ResultsThe best-fitting Mixed Measurement Item Response Theory model with disability covariates identified five classes. Accounting for disability improved differentiation between people reporting isolated non-specific symptoms [‘Somatic’ (13.0%), and ‘Worried’ (14.0%)] and psychopathological symptoms [‘Subclinical’ (8.8%), and ‘Clinical’ (3.3%)]. Classes showed distinct associations with clinically relevant external variables [e.g. somatization: odds ratio (OR) 8.1–12.3, and chronic stress: OR 3.7–4.4]. The Subclinical class reported symptomatology at subthreshold levels while experiencing disability. No pure depression or anxiety, but only mixed classes were found.ConclusionsAn empirical classification model, incorporating both symptoms and disability identified clearly distinct cross-diagnostic subtypes, indicating that diagnostic nets should be cast wider than current phenomenology-based categorical systems.
Network analysis of depression and anxiety symptom relationships in a psychiatric sample
Authors: Beard C. , Millner A. J. , Forgeard M. J. C. , Fried E. I. , Hsu K. J. , Treadway M. T. , Leonard C. V. , Kertz S. J. , Björgvinsson T. 
Published: September 2016

BackgroundResearchers have studied psychological disorders extensively from a common cause perspective, in which symptoms are treated as independent indicators of an underlying disease. In contrast, the causal systems perspective seeks to understand the importance of individual symptoms and symptom-to-symptom relationships. In the current study, we used network analysis to examine the relationships between and among depression and anxiety symptoms from the causal systems perspective.MethodWe utilized data from a large psychiatric sample at admission and discharge from a partial hospital program (N= 1029, mean treatment duration = 8 days). We investigated features of the depression/anxiety network including topology, network centrality, stability of the network at admission and discharge, as well as change in the network over the course of treatment.ResultsIndividual symptoms of depression and anxiety were more related to other symptoms within each disorder than to symptoms between disorders. Sad mood and worry were among the most central symptoms in the network. The network structure was stable both at admission and between admission and discharge, although the overall strength of symptom relationships increased as symptom severity decreased over the course of treatment.ConclusionsExamining depression and anxiety symptoms as dynamic systems may provide novel insights into the maintenance of these mental health problems.
Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
Authors: Spitzer Philipp , Condic Mateja , Herrmann Martin , Oberstein Timo Jan , Scharin-Mehlmann Marina , Gilbert Daniel F. , Friedrich Oliver , Grömer Teja , Kornhuber Johannes , Lang Roland , Maler Juan Manuel 
Published: September 2016

AbstractAmyloid-β (Aβ) peptides are the main components of the plaques found in the brains of patients with Alzheimer’s disease. However, Aβ peptides are also detectable in secretory compartments and peripheral blood contains a complex mixture of more than 40 different modified and/or N- and C-terminally truncated Aβ peptides. Recently, anti-infective properties of Aβ peptides have been reported. Here, we investigated the interaction of Aβ peptides of different lengths with various bacterial strains and the yeast Candida albicans. The amyloidogenic peptides Aβ1-42, Aβ2-42 and Aβ3p-42 but not the non-amyloidogenic peptides Aβ1-40 and Aβ2-40 bound to microbial surfaces. As observed by immunocytochemistry, scanning electron microscopy and Gram staining, treatment of several bacterial strains and Candida albicans with Aβ peptide variants ending at position 42 (Aβx-42) caused the formation of large agglutinates. These aggregates were not detected after incubation with Aβx-40. Furthermore, Aβx-42 exerted an antimicrobial activity on all tested pathogens, killing up to 80% of microorganisms within 6 h. Aβ1-40 only had a moderate antimicrobial activity against C. albicans. Agglutination of Aβ1-42 was accelerated in the presence of microorganisms. These data demonstrate that the amyloidogenic Aβx-42 variants have antimicrobial activity and may therefore act as antimicrobial peptides in the immune system.
An APOC3 3′UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site
Authors: Hu Sen-Lin , Cui Guang-Lin , Huang Jin , Jiang Jian-Gang , Wang Dao-Wen 
Published: September 2016

AbstractApolipoprotein C-III (APOC3) is a key regulator of plasma triglycerides levels. Increasing evidence has shown that loss-of-function mutations in APOC3 is associated with reduction in plasma triglycerides levels and will confer a benefit in patients at high risk for cardiovascular disease. However, these favorable mutations were extremely distribution discrepant among different ethnics. In this study, the APOC3 gene was resequenced and we identified a common variant which located in the microRNA-binding site in APOC3 and would affect its expression and the risk of coronary heart disease (CHD). The molecular mechanism was explored. We found that the T allele of rs4225 suppressed APOC3 translation by facilitating miR-4271 binding, but not the G allele. Subjects carrying the GG genotype had higher plasma APOC3 levels (p for trend = 0.03) than those with the TT genotype. Furthermore, the T allele was significantly associated with decreased triglyceride levels [Beta (SE): −0.024 (0.020), P = 0.03]. Finally, the case-control study suggested that the TT genotype resulted in a significant reduction in overall CHD risk [OR, 0.89 (95% confidence interval, 0.77–0.98), P = 0.009]. In conclusion, our results provide evidence that the rs4225 in the 3′-UTR of APOC3 might contribute to the risk of CHD by interfering with miR-4271 binding.
Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions
Authors: Sawant Kirti V. , Poluri Krishna Mohan , Dutta Amit K. , Sepuru Krishna Mohan , Troshkina Anna , Garofalo Roberto P. , Rajarathnam Krishna 
Published: September 2016

AbstractThe chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting and activating neutrophils for microbial killing at the tissue site. CXCL1 exists reversibly as monomers and dimers, and mediates its function by binding glycosaminoglycans (GAG) and CXCR2 receptor. We recently showed that both monomers and dimers are potent CXCR2 agonists, the dimer is the high-affinity GAG ligand, lysine and arginine residues located in two non-overlapping domains mediate GAG interactions, and there is extensive overlap between GAG and receptor-binding domains. To understand how these structural properties influence in vivo function, we characterized peritoneal neutrophil recruitment of a trapped monomer and trapped dimer and a panel of WT lysine/arginine to alanine mutants. Monomers and dimers were active, but WT was more active indicating synergistic interactions promote recruitment. Mutants from both domains showed reduced GAG heparin binding affinities and reduced neutrophil recruitment, providing compelling evidence that both GAG-binding domains mediate in vivo trafficking. Further, mutant of a residue that is involved in both GAG binding and receptor signaling showed the highest reduction in recruitment. We conclude that GAG interactions and receptor activity of CXCL1 monomers and dimers are fine-tuned to regulate neutrophil trafficking for successful resolution of tissue injury.
Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon
Authors: Li Tianda , Shuai Ling , Mao Junjie , Wang Xuepeng , Wang Mei , Zhang Xinxin , Wang Leyun , Li Yanni , Li Wei , Zhou Qi 
Published: September 2016

AbstractRats with fluorescent markers are of great value for studies that trace lineage-specific development, particularly those assessing the differentiation potential of embryonic stem cells (ESCs). The piggyBac (PB) transposon is widely used for the efficient introduction of genetic modifications into genomes, and has already been successfully used to produce transgenic mice and rats. Here, we generated transgenic rats carrying either the desRed fluorescent protein (RFP) gene or the enhanced green fluorescent protein (eGFP) gene by injecting pronuclei with PB plasmids. We showed that the transgenic rats expressed the RFP or eGFP gene in many organs and had the capability to transmit the marker gene to the next generation through germline integration. In addition, rat embryonic stem cells (ESCs) carrying an RFP reporter gene can be derived from the blastocysts of the transgenic rats. Moreover, the RFP gene can be detected in chimeras derived from RFP ESCs via blastocyst injection. This work suggests that PB-mediated transgenesis is a powerful tool to generate transgenic rats expressing fluorescent proteins with high efficiency, and this technique can be used to derive rat ESCs expressing a reporter protein.
A Simple Adaptive Transfer Function for Deriving the Central Blood Pressure Waveform from a Radial Blood Pressure Waveform
Authors: Gao Mingwu , Rose William C. , Fetics Barry , Kass David A. , Chen Chen-Huan , Mukkamala Ramakrishna 
Published: September 2016

AbstractGeneralized transfer functions (GTFs) are available to compute the more relevant central blood pressure (BP) waveform from a more easily measured radial BP waveform. However, GTFs are population averages and therefore may not adapt to variations in pulse pressure (PP) amplification (ratio of radial to central PP). A simple adaptive transfer function (ATF) was developed. First, the transfer function is defined in terms of the wave travel time and reflection coefficient parameters of an arterial model. Then, the parameters are estimated from the radial BP waveform by exploiting the observation that central BP waveforms exhibit exponential diastolic decays. The ATF was assessed using the original data that helped popularize the GTF. These data included radial BP waveforms and invasive reference central BP waveforms from cardiac catheterization patients. The data were divided into low, middle, and high PP amplification groups. The ATF estimated central BP with greater accuracy than GTFs in the low PP amplification group (e.g., central systolic BP and PP root-mean-square-errors of 3.3 and 4.2 mm Hg versus 6.2 and 7.1 mm Hg; p ≤ 0.05) while showing similar accuracy in the higher PP amplification groups. The ATF may permit more accurate, non-invasive central BP monitoring in elderly and hypertensive patients.
Simple and rapid detection of Tilletia horrida causing rice kernel smut in rice seeds
Authors: Chen Yu , Yang Xue , Yao Jian , Kyaw Ei Phyu , Zhang Ai-Fang , Li Yun-Fei , Gu Chun-Yan , Zang Hao-Yu , Gao Tong-Chun 
Published: September 2016

AbstractA simple and rapid method for the detection of Tilletia horrida, the causal agent of rice kernel smut, in rice seeds is developed based on specific polymerase chain reaction (PCR). To design the specific primers for the detection of T. horrida, partial sequences of internal transcribed spacer (ITS) DNA region of T. horrida, T. controversa, T. walkeri, T. ehrhartae, T. indica and T. caries were analyzed and compared. A 503-bp fragment was amplified with the designed primers from the T. horrida genomic DNA. However, no PCR product was obtained from the DNA of other five Tilletia species and 22 fungal plant pathogens tested in the present work indicating the specificity of the primers for the detection of T. horrida. The PCR was performed by directly using the spores, isolated from the 21 different rice seed samples, as template DNA. The T. horrida was detected in 6 of the samples, indicating that 28.6% of the rice samples were contaminated with the kernel smut pathogen. This simple PCR based diagnostic assay can be applied for the direct and rapid detection and identification of T. horrida to screen large numbers of rice seed samples.
Emergence of event cascades in inhomogeneous networks
Authors: Onaga Tomokatsu , Shinomoto Shigeru 
Published: September 2016

AbstractThere is a commonality among contagious diseases, tweets, and neuronal firings that past events facilitate the future occurrence of events. The spread of events has been extensively studied such that the systems exhibit catastrophic chain reactions if the interaction represented by the ratio of reproduction exceeds unity; however, their subthreshold states are not fully understood. Here, we report that these systems are possessed by nonstationary cascades of event-occurrences already in the subthreshold regime. Event cascades can be harmful in some contexts, when the peak-demand causes vaccine shortages, heavy traffic on communication lines, but may be beneficial in other contexts, such that spontaneous activity in neural networks may be used to generate motion or store memory. Thus it is important to comprehend the mechanism by which such cascades appear, and consider controlling a system to tame or facilitate fluctuations in the event-occurrences. The critical interaction for the emergence of cascades depends greatly on the network structure in which individuals are connected. We demonstrate that we can predict whether cascades may emerge, given information about the interactions between individuals. Furthermore, we develop a method of reallocating connections among individuals so that event cascades may be either impeded or impelled in a network.
Decreasing prevalence and time trend of gastroschisis in 14 cities of Liaoning Province: 2006–2015
Authors: Li Na , Chen Yan-Ling , Li Jing , Li Li-Li , Jiang Cheng-Zhi , Zhou Chen , Liu Cai-Xia , Li Da , Gong Ting-Ting , Wu Qi-Jun , Huang Yan-Hong 
Published: September 2016

AbstractTo identify trends in the prevalence of gastroschisis on the basis of a large population-based observation study with cases identified by the Liaoning Birth Defects Registry including 14 cities over the course of a 10-year period. Data were obtained from the aforementioned registry which was maintained by the Liaoning Women and Children’s Health Hospital, a comprehensive care institution as well as being responsible for the women’s and children’s health care guidance in this province. Gastroschisis prevalence, percent change, annual percent change (APC), and contribution rates of each city were calculated. We observed 747 cases of gastroschisis among 3,248,954 live births, for a prevalence of 2.30 per 10,000 births. The gastroschisis prevalence significantly decreased by 12.63% per year in Liaoning Province. Although the decreasing trends were observed in all these 14 cities, significant results were only observed in Shenyang (APC = −16.31%), Tieling (APC = −20.23%), and Chaoyang (APC = −13.50%). Notably, Tieling, Shenyang, and Yingkou were the three major cities which contributed almost 37.17% of the decreasing trend of gastroschisis in Liaoning Province. In conclusion, our findings demonstrate that the prevalence of gastroschisis has been decreasing during the recent decade among 14 cities in Liaoning Province.
Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration
Authors: Noailles Agustina , Maneu Victoria , Campello Laura , Gómez-Vicente Violeta , Lax Pedro , Cuenca Nicolás 
Published: September 2016

AbstractMicroglia act as the resident immune cells of the central nervous system, including the retina. In response to damaging stimuli microglia adopt an activated state, which can progress into a phagocytic phenotype and play a potentially harmful role by eliciting the expression and release of pro-inflammatory cytokines. The aim of the present study was to assess longitudinal changes in microglia during retinal degeneration in the homozygous P23H rat, a model of dominant retinitis pigmentosa. Microglial phenotypes, morphology and density were analyzed by immunohistochemistry, flow cytometry, and cytokine antibody array. In addition, we performed electroretinograms to evaluate the retinal response. In the P23H retina, sclera, choroid and ciliary body, inflammatory cells increased in number compared with the control at all ages analyzed. As the rats became older, a higher number of amoeboid MHC-II+ cells were observed in the P23H retina, which correlated with an increase in the expression of pro-inflammatory cytokines. These findings suggest that, in the P23H model, retinal neuroinflammation persists throughout the rat’s life span even after photoreceptor depletion. Therefore, the inclusion of anti-inflammatory drugs at advanced stages of the neurodegenerative process may provide better retinal fitness so the remaining cells could still be used as targets of cellular or gene therapies.
Integrin α6/Akt/Erk signaling is essential for human breast cancer resistance to radiotherapy
Authors: Hu Ting , Zhou Rui , Zhao Yanxia , Wu Gang 
Published: September 2016

AbstractIntegrin α6 (ITGA6), a transmembrane glycoprotein adhesion receptor protein, is widely upregulated in many types of tumors and promotes migration and invasion in cancer cells. However, the role that the ITGA6-associated signaling network plays in radiosensitivity in breast cancer has not been described. The expression of ITGA6 was examined in human breast cancer and normal breast cell lines using western blot analysis. We also explored the role of ITGA6 in the regulation of radiation sensitivity in breast cancer using the colony formation assays, cell cycle analyses, apoptosis assays and immunofluorescence analyses. The results showed that the protein and mRNA expression levels of ITGA6 was higher in breast cancer cells than in normal cells. ITGA6 protectived responses to radiotherapy in breast cancer cells by altering cell apoptosis, DNA damage repair and cell-cycle regulation. Furthermore, ITGA6 enhanced radiation resistance via PI3K/Akt and MEK/Erk signaling. In addition, overexpressing ITGA6 promoted radiation resistance in cells, and this effect was neutralized by the PI3K inhibitor LY294002 and MEK inhibitor U0126. Taken together, these findings indicate that ITGA6 might be involved in a mechanism that underlies radiation resistance and that ITGA6 could be a potential target for therapies aimed at overcoming radiation resistance in breast cancer.
Topological band-order transition and quantum spin Hall edge engineering in functionalized X-Bi(111) (X = Ga, In, and Tl) bilayer
Authors: Kim Youngjae , Yun Won Seok , Lee J. D. 
Published: September 2016

AbstractFunctionalized X-Bi bilayers (X = Ga, In, and Tl) with halogens bonded on their both sides have been recently claimed to be the giant topological insulators due to the strong band inversion strengths. Employing the first-principles electronic structure calculation, we find the topological band order transition from the order p – p – s of the X-Bi bilayers with halogens on their both sides to the new order p – s – p of the bilayers (especially for X = Ga and In) with halogen on one side and hydrogen on the other side, where the asymmetric hydrogen bonding simulates the substrate. We further find that the p – s bulk band gap of the bilayer bearing the new order p – s – p sensitively depends on the electric field, which enables a meaningful engineering of the quantum spin Hall edge state by controlling the external electric field.
High‐frequency InGaAs tri‐gate MOSFETs with fmax of 400 GHz
Authors: Zota C.B. , Lindelöw F. , Wernersson L.‐E. , Lind E. 
Published: September 2016

Extremely scaled down tri‐gate RF metal‐oxide‐semiconductor field‐effect transistors (MOSFETs) utilising lateral nanowires as the channel, with gate length and nanowire width both of 20 nm are reported. These devices exhibit simultaneous extrapolated ft and fmax of 275 and 400 GHz at VDS = 0.5 V, which is the largest combined ft and fmax, as well as the largest fmax reported for all III–V MOSFETs.