bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploratory analysis of osteoarthritis progression among medication users: data from the Osteoarthritis Initiative
Authors: Driban Jeffrey B. , Lo Grace H. , Eaton Charles B. , Lapane Kate L. , Nevitt Michael , Harvey William F. , McCulloch Charles E. , McAlindon Timothy E. 
Published: August 2016

Background: We conducted an exploratory analysis of osteoarthritis progression among medication users in the Osteoarthritis Initiative to identify interventions or pathways that may be associated with disease modification and therefore of interest for future clinical trials. Methods: We used participants from the Osteoarthritis Initiative with annual medication inventory data between the baseline and 36-month follow-up visit ( n = 2938). Consistent medication users were defined for each medication classification as a participant reporting at all four annual visits that they were regularly using an oral prescription medication at the time of the visit. The exploratory analysis focused on medication classes with 40 or more users. The primary outcome measures were medial tibiofemoral joint space width change and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) knee pain score change (12–36-month visits). Within each knee, we explored eight comparisons between users and matched or unmatched nonusers (defined two ways). An effect size of each comparison was calculated. Medication classes had potential signals if (a) both knees had less progression among users compared with nonusers, or (b) there was less progression based on structure and symptoms in one knee. Results: We screened 28 medication classes. Six medication classes had signals for fewer structural changes and better knee pain changes: alpha-adrenergic blockers, antilipemic (excluding statins and fibric acid), anticoagulants, selective serotonin reuptake inhibitors, antihistamines, and antineoplastic agents. Four medication classes had signals for structural changes alone: anti-estrogen (median effect size = 0.28; range = −0.41–0.64), angiotensin-converting enzyme inhibitors (median effect size = 0.13; range = −0.08–0.28), beta-adrenergic blockers (median effect size = 0.09; range = 0.01–0.30), and thyroid agents (median effect size = 0.04; range = −0.05–0.14). Thiazide diuretics had evidence for symptom modification (median effect size = −0.12; range = −0.24–0.04). Conclusions: Users of neurovascular, antilipemic, or hormonal interventions may have less disease progression compared with nonusers.
T2* Mapping for Hip Joint Cartilage Assessment: Pre-MRI Exercise and Time of Imaging Do Not Bias the T2* Measurement in Asymptomatic Volunteers
Authors: Hesper Tobias , Hosalkar Harish S. , Schleich Christoph , Antoch Gerald , Welsch Götz H. , Krauspe Rüdiger , Zilkens Christoph , Bittersohl Bernd 
Published: August 2016

Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo steady state (DESS) sequence for morphological cartilage assessment and a multi-echo data image combination sequence for the T2* measurement. T2* values were obtained between 8 and 11 a.m., between 3 and 6 p.m., and after 50 knee-bends at several time points of each measurement (0, 15, 30, 45, 60 minutes). Results We observed no differences ( P = 0.47) between the T2* values obtained in the morning (T2* = 22.9 ± 3.0 ms) and those measured in the afternoon (T2* = 23.2 ± 3.2 ms). We also observed no statistically significant differences between the T2* values at different time points ( P = 0.67) or after 50 knee-bends ( P = 0.43). Conclusions Timing of the scan and pre-imaging exercise clearly did not matter in this modality. This study consolidates the value of T2* imaging in hip joint cartilage that seems to be independent of diurnal effects and physical activity prior to MRI.
Assessment of diffusion tensor imaging metrics in differentiating low-grade from high-grade gliomas
Authors: El-Serougy Lamiaa , Abdel Razek Ahmed Abdel Khalek , Ezzat Amani , Eldawoody Hany , El-Morsy Ahmad 
Published: August 2016

Aim The aim of this article is to assess diffusion tensor imaging (DTI) metrics in differentiating low-grade from high-grade gliomas. Patients and methods A prospective study was conducted on 35 patients with gliomas who underwent DTI. Gliomas were classified into low-grade and high-grade gliomas. The fractional anisotropy (FA), mean diffusivity (MD), linear coefficient (CL), planar coefficient (CP) and spherical coefficient (CS) of the solid tumoral part and peri-tumoral regions were calculated. Results There was significant difference ( p = 0.001) in MD of the solid tumoral part of low-grade (1.78 ± 0.33 × 10−3 mm2/s) and high-grade (1.16 ± 0.22 × 10−3 mm2/s) gliomas. The selection of 1.42 × 10−3 mm2/s as a cutoff value of MD of the tumoral part was used to differentiate low-grade and high-grade gliomas; the best results were obtained with area under the curve (AUC) of 0.957 and accuracy of 91.4%. There was a significant difference in FA, MD, CP and CS of peri-tumoral regions of both groups with p values of 0.006, 0.042, 0.030 and 0.037, respectively. The cutoff values of MD, FA, CS and CP of the peri-tumoral region used to differentiate low-grade from high-grade gliomas were 1.24, 0.315, 0.726 and 0.321 with AUC of 0.694, 0.773, 0.734 and 0.724 and accuracy of 68.6%, 80.0%, 74.3% and 74.3%, respectively. The combined MD of the solid tumoral part and FA of the peri-tumoral region used to differentiate low-grade from high-grade gliomas revealed AUC of 0.974 and accuracy of 88.6%. Conclusion We conclude that the combination of MD of the solid tumoral part and FA of the peri-tumoral region is a noninvasive method to differentiate low-grade from high-grade gliomas.
Statistical inference for time course RNA-Seq data using a negative binomial mixed-effect model
Authors: Sun Xiaoxiao , Dalpiaz David , Wu Di , S. Liu Jun , Zhong Wenxuan , Ma Ping 
Published: August 2016

AbstractBackgroundAccurate identification of differentially expressed (DE) genes in time course RNA-Seq data is crucial for understanding the dynamics of transcriptional regulatory network. However, most of the available methods treat gene expressions at different time points as replicates and test the significance of the mean expression difference between treatments or conditions irrespective of time. They thus fail to identify many DE genes with different profiles across time. In this article, we propose a negative binomial mixed-effect model (NBMM) to identify DE genes in time course RNA-Seq data. In the NBMM, mean gene expression is characterized by a fixed effect, and time dependency is described by random effects. The NBMM is very flexible and can be fitted to both unreplicated and replicated time course RNA-Seq data via a penalized likelihood method. By comparing gene expression profiles over time, we further classify the DE genes into two subtypes to enhance the understanding of expression dynamics. A significance test for detecting DE genes is derived using a Kullback-Leibler distance ratio. Additionally, a significance test for gene sets is developed using a gene set score.ResultsSimulation analysis shows that the NBMM outperforms currently available methods for detecting DE genes and gene sets. Moreover, our real data analysis of fruit fly developmental time course RNA-Seq data demonstrates the NBMM identifies biologically relevant genes which are well justified by gene ontology analysis.ConclusionsThe proposed method is powerful and efficient to detect biologically relevant DE genes and gene sets in time course RNA-Seq data.
Chloride content of solutions used for regional citrate anticoagulation might be responsible for blunting correction of metabolic acidosis during continuous veno-venous hemofiltration
Authors: Jacobs Rita , Honore Patrick M. , Diltoer Marc , Spapen Herbert D. 
Published: August 2016

Abstract

Background
Citrate, the currently preferred anticoagulant for continuous veno-venous hemofiltration (CVVH), may influence acid-base equilibrium.

Methods
The effect of 2 different citrate solutions on acid-base status was assessed according to the Stewart-Figge approach in two consecutive cohorts of critically ill adult patients. The first group received Prismocitrate 10/2 (PC10/2; 10 mmol citrate/L). The next group was treated with Prismocitrate 18/0 (PC18; 18 mmol citrate/L). Both groups received bicarbonate-buffered fluids in post-dilution.

Results
At similar citrate flow, the metabolic acidosis present at baseline in both groups was significantly attenuated in PC18 patients but persisted in PC10/2 patients after 24 h of treatment (median pH 7,42 vs 7,28; p = 0.0001). Acidosis in the PC10/2 group was associated with a decreased strong ion difference and an increased strong ion gap (respectively 43 vs. 51 mmol/L and 17 vs. 12 mmol/L, PC10/2 vs. PC18; both p = 0.001). Chloride flow was higher in PC10/2 than in PC18 subjects (25.9 vs 14.3 mmol/L blood; p < 0.05).

Conclusion
Correction of acidosis was blunted in patients who received 10 mmol citrate/L as regional anticoagulation during CVVH. This could be explained by differences in chloride flow between the applied citrate solutions inducing hyperchloremic acidosis.
Respondent driven sampling of wheelchair users: A lack of traction?
Authors: Bourke John A. , Schluter Philip J. , Hay-Smith E. Jean C. , Snell Deborah L. 
Published: August 2016

Background: Internationally, wheelchair users are an emerging demographic phenomenon, due to their increased prevalence and rapidly increasing life-span. While having significant healthcare implications, basic robust epidemiological information about wheelchair users is often lacking due, in part, to this population’s ‘hidden’ nature. Increasingly popular in epidemiological research, Respondent Driven Sampling (RDS) provides a mechanism for generating unbiased population-based estimates for hard-to-reach populations, overcoming biases inherent within other sampling methods. This paper reports the first published study to employ RDS amongst wheelchair users. Methods: Between October 2015 and January 2016, a short, successfully piloted, internet-based national survey was initiated. Twenty seeds from diverse organisations were invited to complete the survey then circulate it to peers within their networks following a well-defined protocol. A predetermined reminder protocol was triggered when seeds or their peers failed to respond. All participants were entered into a draw for an iPad. Results: Overall, 19 people participated (nine women); 12 initial seeds, followed by seven second-wave participants arising from four seeds. Completion time for the survey ranged between 7 and 36 minutes. Despite repeated reminders, no further people were recruited. Discussion: While New Zealand wheelchair user numbers are unknown, an estimated 14% of people have physical impairments that limited mobility. The 19 respondents generated from adopting the RDS methodology here thus represents a negligible fraction of wheelchair users in New Zealand, and an insufficient number to ensure equilibrium required for unbiased analyses. While successful in other hard-to-reach populations, applying RDS methodology to wheelchair users requires further consideration. Formative research exploring areas of network characteristics, acceptability of RDS, appropriate incentive options, and seed selection amongst wheelchair users is needed.
The Sources of the Communication Gap
Authors: He Simin , Offerman Theo , van de Ven Jeroen 
Published: August 2016

Face-to-face communication drastically increases cooperation rates in social dilemmas. We test which factors are the most important drivers of this communication gap. We distinguish three main categories. First, communication may decrease social distance. Second, communication may enable subjects to assess their opponent’s cooperativeness (“type detection”) and condition their own action on that information. Third, communication allows subjects to make promises, which create commitment for subjects who do not want to break a promise. We find that communication increases cooperation very substantially. In our experiment, we find that commitment value is an important factor, but the largest part of the increase can be attributed to type detection. We do not find evidence that social distance plays a role. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2016.2518 . This paper was accepted by Uri Gneezy, operations management.
Maid to serve: ‘Self-fashioning’ and the domestic worker trope in contemporary South Africa
Authors: Mahali Alude 
Published: August 2016

Abstract
This article investigates how the domestic worker sartorial trope is reflected and embodied in contemporary South African culture. Domestic work has received very little public or media attention from feminists, trade unionists, or even political activists broadly until the recent movement of the Economic Freedom Fighters (EFF). This article observes how the South African political party, the EFF, use the domestic worker dress as a subversionary tactic in sociopolitical culture. By appropriating the archetypal domestic worker dress, the EFF demonstrate both identification with the domestic worker and a subversion of what the domestic worker dress has, for so long, inferred. In the context of post-apartheid South Africa, the author examines the domestic worker trope and the significance of dress. This article uses critical discourse analysis and Pierre Bourdieu’s theory of habitus to explicate both the personal and political significance of the domestic worker dress in contemporary South Africa.
Zimbabwe’s state-controlled public media and the mediation of the 1980s genocide 30 years on
Authors: Mpofu Shepherd 
Published: August 2016

Abstract
Since the end of genocide in 1987 Zimbabwe has remained a zone of ‘conflicts’, and the enduring debates surrounding this genocide, especially in public-owned but state-controlled media, call for critical attention. Three years after independence, in 1980, Zimbabwe was plunged into a genocide named ‘Gukurahundi’ (meaning the rain that washes the chaff away after harvest) that lasted until 1987. This article argues that there has been a clash of ‘interests’ playing out in the mediation of this yet-to-be-officially addressed genocide. Through evidence from public-owned media, the media that carry the official voice of the ruling party, I argue that public media have seen genocide from conflicting and complex angles, making it difficult to reach a consensus suitable for national building based on genocide truths, meanings and effects to Zimbabweans. I specifically use the Unity Accord-associated holiday, the Unity Day, and its associated debates to pursue two arguments. First, public media have played an ambiguous role in appreciating the conflictual and multipronged nature of the genocide within ZANU-PF. Second, public media have largely been supportive of, and even complicit in, official silences on genocide debates and memory. The article uses public sphere and narrative analysis as frameworks for understanding the operations of public media journalism in the mediation of genocide nearly 30 years after its occurrence.
Tweeting democracy: An ethnographic content analysis of social media use in the differing politics of Senegal and Ethiopia’s newspapers
Authors: Lemke Jeslyn , Chala Endalk 
Published: August 2016

Abstract
This descriptive, empirical study gives context to how print journalists in two politically different African nations, Senegal and Ethiopia, use Twitter and Facebook to report the news and to what extent. We ask, ‘how is this new model of online reporting manifesting itself in Ethiopian and Senegalese newsrooms, given Senegal’s track record of democratic government and free press and Ethiopia’s infamously authoritarian control and censorship of the country’s journalists?’. The method is a content analysis of 60 days of posts on ten print newspapers’ Twitter and Facebook pages, to establish a comparative assessment of the two nations. Findings are also given context by comparing the print newspapers’ popularity on Twitter and Facebook against each nation’s top 20 most popular Twitter and Facebook pages. Results show Ethiopia to be markedly behind in Twitter posts, but the newspapers of each country show similar rates of posting to Facebook. Journalists in both nations are not livetweeting events, but instead are linking content on social media to the newspaper’s main home page.
Lovers in Time – practice research in the times of patriotic journalism in Zimbabwe
Authors: Piotrowska Agnieszka 
Published: August 2016

Abstract
This article features my practice research in Zimbabwe. In particular, I focus on the issues surrounding the staging of the most controversial theatrical play during the Harare International Festival of the Arts in 2014, Lovers in Time, written by Zimbabwean Blessing Hungwe and produced and directed by myself. I present the case against the background of the media furore that surrounded the production. I see the press reactions, which changed from very positive to irrationally vitriolic, as an example of patriotic journalism and Althusserian interpellation. Under the particular circumstances in Zimbabwe, my whiteness, gender and European background were also an issue discussed both in the media and among the members of our theatrical company when decisions had to be made regarding where the lines of belonging lie and why. The article suggests that open discussions of this nature might be helpful in terms of de-mystifying the cultural challenges and subverting patriarchal notions of production of knowledge in which the myth of objectivity is still advanced as the only valid scholarly interrogation.
Wu Jianren’s New Story of the Stone and interrogating turn-of-the-century urbanist ideology in China
Authors: Marling Tom 
Published: August 2016

Abstract
Chinese cities experienced both significant material and conceptual changes in the late nineteenth century, but this was not well represented in popular fiction. The influence of an emerging discourse of urbanism does however make its presence felt, and novels like New Story of the Stone turned a satirical eye towards such a discourse. This article considers how New Story comically inhabits the contrast between the ‘barbarian’ and ‘civilized’ cities that was shaping proto-urbanism in China, but in doing so engages with more complex issues of ‘inhabiting’ and ‘habitat’. By considering the polyphony inherent to the concept of urban barbarity, and contrasting this with the anodyne homogeneity of civility in the city, Wu Jianren leverages his own personal engagement with ‘writing’ cities to undermine a burgeoning functionalism and positivism surrounding the city in modernizing China.
A Bildungsroman for a waterfront development: Literary genre and the planning narratives of Jätkäsaari, Helsinki
Authors: Ameel Lieven 
Published: August 2016

Abstract
This article examines the narratives involved in the planning of Jätkäsaari (Helsinki), an industrial harbour environment currently being redeveloped. It starts out with an analysis of Hyvä jätkä/Good Chap (Hannu Mäkelä, 2009), a literary novel commissioned by the city to promote the area, arguing that this cultural product should not be seen merely as a piece of cultural branding. Rather, the novel’s fictional construction of the area’s past and future draws attention to the narrative characteristics of planning itself. Using the concepts of literary genre and metaphor, an examination of Jätkäsaari’s planning narratives shows the ambivalent and often contradictory planning visions of the area. This study aims at re-examining the considerable research tradition in urban and planning studies that sees urban planning as a form of storytelling, by applying concepts from literary and narrative theory to the analysis of planning narratives.
Festival and tradition in contemporary Florence
Authors: Frost Christian 
Published: August 2016

Abstract
Certain sectors of the heritage and tourist industry argue that cities with art historical significance should be re-categorized as ‘museum cities’ because visitors intent on acquiring particular limited ‘consumer’ experiences outnumber the local population. Using the Feast Day of San Giovanni in Florence, Italy, as a focus this article questions this assumption. By evaluating the form of the feast day events and their relationship to the urban landscape, some of the historical conditions that have shaped the city are revealed. These conditions, understood as civic praxis, are accessible to everyone (to different degrees) and suggest Florence is anything but a museum.
Tracing the Politics of Urbanism and Abjection: Space and Identity in Trainspotting
Authors: Salvador D’Ambrosio Gabriela 
Published: August 2016

Abstract
Given the fundamental role cities play in the experience of modernity and postmodernity, this article studies the interaction existing between urban space and the individuals who inhabit it in the context of Irvine Welsh’s novel, Trainspotting. A multidisciplinary approach combining theories on the city and queer theory explores the subject/space dialectics by which each of them intervenes in the construction of the other. The analysis of this process centres around three main issues – urbanism, abjection and movement – and their underlying ideology.
The Rheological Properties of Redcurrant and Highbush Blueberry Berries
Authors: Bohdziewicz Jerzy , Czachor Gabriel 
Published: August 2016

Abstract
The load values corresponding to the compressive strength of high-bush blueberry and redcurrant fruits during the compression test between two rigid plates were measured. The changes of coefficient of elasticity and coefficient of viscosity values during the creep and the relaxation tests were studied in the selected interval of time, also direction of load application in relation to the longitudinal axis of fruit was considered. The creep and relaxation tests were carried out with the load of 40% of determined compressive strength of berries. To describe behavior of testing the material rheological standard, Maxwell and Kelvin models as well as experimental models were used. Comparatively small changes of parameter values of assumed empirical models were reported in the course of tests. It may be recognized as characteristic for the investigated material.
The Use of Precise Agriculture Technology in a Farm in Podlasie Region
Authors: Borusiewicz Andrzej , Kapela Krzysztof , Drożyner Paulina 
Published: August 2016

Abstract
The article presents advantages resulting from implementation of the precise agriculture technology in a farm. The objective of the paper was to analyse devices used in precise agriculture on the example of the selected agricultural farm located in Podlaskie Voivodeship. Documentation of the farm and data included in the questionnaire of the survey carried out with the farm owner were the source of indispensable information. For determination of the costs of return of investments planned in the farm, the method of data analysis and TeeJeet calculation were used. Implementation of the precise agriculture technology in the investigated farm caused reduction of the costs related to running a farm. The introduced changes allowed saving approximately PLN 14 thousand annually on crop protection treatments and approximately PLN 19 thousand annually on the precise sowing of mineral fertilizers. Costs related to the purchase of devices which allow generation of such savings return after 3-4 years.