bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Clinical Results between Heparin Surface Modified Hydrophilic Acrylic and Hydrophobic Acrylic Intraocular Lens
Authors: Kang S. , Kim M.-J. , Park S.-H. , Joo C.-K. 
Published: January 2018

Purpose To compare the clinical results of heparin surface modified (HSM) hydrophilic acrylic intraocular lens (IOL) with those of hydrophobic acrylic IOL. Methods One hundred patients with cataract were randomized to receive one of acrylic foldable IOLs after phacoemulsification: HSM hydrophilic acrylic IOL (n=50) BioVue3® (BioVue, OII, Ontario, CA, USA) and hydrophobic acrylic IOL (n=50) Sensar® (AR40e, AMO, Santa Ana, CA, USA). Best-corrected visual acuity and refractive error were measured at 1 week, 2 months, 6 months and 12 months after surgery in both IOL groups. To assess posterior capsular opacification (PCO), digital retroillumination image of posterior capsule was analyzed at 12 months using POCOman software. Results Best-corrected visual acuity (log MAR) was 0.032±0.082 in BioVue3® group and 0.034±0.077 in Sensar® group at 12 months. There was no statistically significant difference between the two groups (p=0.554). Refractive error was −0.247±0.821 diopter in BioVue3® group and −0.264±0.808 diopter in Sensar® group at 12 months. There was no statistically significant difference of refractive error between the two groups (p=0.909). At 12 months, BioVue3® IOL group had a lower percentage area and severity of PCO than Sensar® group. However, it was not statistically significant (p=0.349, p=0.288). No Nd:YAG capsulotomy was performed in BioVue3® group while it was required in two eyes (4.0%) in Sensar® group. Conclusions There was no statistically significant difference of postoperative visual acuity, refractive error and degree of PCO between HSM hydrophilic acrylic IOL and hydrophobic acrylic IOL.
Primary Phacoemulsification and Aspiration Combined with 25-Gauge Single-Port Vitrectomy for Management of Acute Angle Closure
Authors: Miura S. , Ieki Y , Ogino K. , Tanaka Y 
Published: January 2018

Purpose To describe a technique using phacoemulsification and aspiration (PEA) combined with 25-gauge single-port vitrectomy as a primary treatment for acute angle closure (AAC). Methods Seventeen consecutive cases of AAC were treated with 1) transconjunctival limited single-port vitrectomy with a 25-gauge vitrector and 2) transcorneal PEA and cortex removal followed by implantation of foldable intraocular lenses (IOL). Results Intraocular pressure (IOP) control was achieved in all 17 eyes examined. Mean preoperative IOP was 51.8±13.1 mmHg, and mean IOP on postoperative day 1 was 18.3±8.5 mmHg. Additional anti-glaucoma surgery was necessary in one eye. IOL could not be implanted because of zonular dialysis in one eye. Postoperative complications were seen in three cases (one retinal hemorrhage and two papilledema). Conclusions The PEA procedure is efficient as a primary treatment of AAC. Single-port vitrectomy with a 25-gauge vitrector facilitated PEA and IOL implantation.
Incomplete Posterior Hyaloid Detachment after Intravitreal Pegaptanib Injection in Diabetic Macular Edema
Authors: Montero J.A. , Ruiz-Moreno J.M. , De La Vega C. 
Published: January 2018

Purpose Posterior hyaloid adherences play a role in the pathogenesis of diabetic macular edema (DME). Intravitreal antivascular endothelial growth factor (VEGF) drugs are presently being used to treat DME. The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME. This case shows a combined mechanism of DME resolution by anti VEGF and PHD. Methods Prospective, interventional, single case report. One male patient with bilateral DME was treated by intravitreal pegaptanib in his right eye every 6 weeks for 6 months (five injections) and followed for 42 months. Results Central macular thickness decreased from 511 to 376 μm at month 4 in the treated eye and remained within 10% of this value during follow-up. The posterior hyaloid became taut and partially detached after the third injection and was almost completely detached 1 year later. Visual acuity remained unchanged in both eyes during follow-up. Conclusions PHD may play an important role in cases where macular thickness is successfully reduced or better acuity is achieved after intravitreal injections.
Metastatic Renal Cell Carcinoma Presenting as a Circumscribed Orbital Mass
Authors: Mudiyanselage S.Y. , Prabhakaran V.C. , Davis G.J. , Selva D. 
Published: January 2018

Purpose To report a case of renal cell carcinoma presenting as a well-circumscribed orbital tumor. Methods Retrospective interventional case report. Results A 60-year-old woman presented with proptosis of the left eye. Imaging showed a well circumscribed tumor in the region of the medial rectus muscle. Excision biopsy revealed a diagnosis of metastatic renal cell carcinoma that was confirmed on abdominal imaging. Conclusions Renal cell carcinoma can rarely present as a well-circumscribed orbital mass and should be included in the differential diagnosis of such lesions.
Strabismus in Developmental Cataract
Authors: Magli A. , Iovine A. , Bruzzese D. , Giani U. , Fimiani F. 
Published: January 2018

Purpose To evaluate the presence of strabismus in patients with developmental cataract rendered pseudophakic and how this influences their visual acuity. Methods A retrospective study was carried out on 113 patients with developmental cataract who came under the authors' observation at the outpatient department of the Pediatric Ophthalmology Unit of the University of Federico II of Naples from 1990 to 2005. All patients were followed up for a long period (mean 62 months, range 36–144 months). Age at diagnosis, sex, laterality, age at cataract extraction, morphology, and cataract density were all considered as possible factors associated with strabismus. Visual acuity and ocular motility before and after cataract extraction surgery were especially noted. Statistical evaluation was performed using t-test, Chisquare test, and Fisher exact test. Results Out of the 113 patients a total of 181 eyes were affected: 68 patients (60%) presented bilateral cataract, 45 patients (40%) monolateral cataract. Strabismus was present in 39 patients (34%) before cataract surgery. Age at cataract diagnosis, age at surgery, sex, and cataract morphology were not found to be statistically associated with strabismus. However, laterality was found to be statistically associated with the onset of strabismus. Cataract density was found to be statistically associated with poor vision. Patients with strabismus presented a non statistically significant lower visual acuity. Conclusions Strabismus has a greater incidence in developmental cataract compared to the general population, and can influence visual acuity, especially in monolateral and total cataracts. Intraocular lens implants produced satisfactory visual rehabilitation.
Loxosceles Reclusa Bite to the Eyelid
Authors: Keklikci U. , Akdeniz S. , Sakalar Y.B. , Cakmak S.S. , Unlu K. 
Published: January 2018

Purpose The authors report a case of Loxosceles reclusa infestation on the eyelid. Methods The specimen collected by swabbing the lesions with gauze was tested by using a venom-specific enzyme-linked immunosorbent assay Loxosceles venom was detected in specimen. The patient was managed with conservative therapy that included saline compresses and ocular lubrication. Results The case presented with severe edema and necrosis on the left upper eyelid. On laboratory examination, a significant left shift of white blood cell count was detected. Although residual scar of the eyelid and punctate epitheliopathy on the inferior of cornea was detected, vision was not impaired. Conclusions Supportive therapy may be reasonable treatment for Loxosceles reclusa infestation on the eyelids. The presence of venom proteins detected with an enzyme-linked immunosorbent assay technique is beneficial for supporting the diagnosis of Loxosceles envenomatio.
Short-Term Anatomic Effect of Ranibizumab for Polypoidal Choroidal Vasculopathy
Authors: Reche-Frutos J. , Calvo-Gonzalez C. , Donate-Lopez J. , Garcia-Feijoo J. , Leila M. , Garcia-Sanchez J. 
Published: January 2018

Purpose To assess the short-term anatomic effect of intravitreal ranibizumab for polypoidal choroidal vasculopathy. Methods All patients had undergone a full ophthalmic examination. A monthly injection of ranibizumab was performed for 3 months. Indocyanine angiography (ICG) and optical coherence tomography (OCT) were performed 1 month after the third-month ranibizumab injection. Results Polyps disappeared on ICG angiography in 9 out of 13 lesions (69.2%). Retinal thickness diminished significantly on OCT (p=0.02). In our series we noticed a significant reduction of the percentage of patients presenting with subretinal fluid (p=0.02) and pigment epithelium detachment between the initial and final visits (0.016). In addition, we noticed that BCVA increased significantly (p 0.02). Conclusions Monthly intravitreal injection of ranibizumab for 3 months has a short-term beneficial anatomic effect.
Amniotic Membrane Transplantation in Severe Ocular Surface Disorders
Authors: Kaup M. , Redbrake C. , Plange N. , Arend K.O. , Remky A. 
Published: January 2018

Purpose Amniotic membrane transplantation is currently being used as an alternative approach to treat severe corneal surface disorders refractory to medical therapy. The authors report complications of corneal surface disorders after successful amniotic membrane transplantation. Methods Case series. Results Twenty-eight patients with corneal surface disorders due to severe chemical burns, corneal ulceration, or persistent epithelium defects were treated with amniotic membrane transplantation. Four of these patients showed a spontaneous perforation and three patients developed a descemetocele within 6 weeks after the amniotic membrane transplantation. Conclusions In this case series, descemetocele and corneal perforation occurred in 25% of the patients after amniotic membrane transplantation. This might be due to the severity of the underlying disease or to the impact of amniotic membrane on corneal fibroblasts and collagenases. The risk of corneal thinning and perforation should be considered in the decision of treatment with amnion and follow-up regimen.
Comparison of Higher Order Aberrations with Spherical and Aspheric Iols Compared to Normal Phakic Eyes
Authors: Rękas M. , Krix-Jachym K. , Żelichowska B. 
Published: January 2018

Purpose To compare higher order aberrations (HOA) in AcrySof SN60AT and Acrysof IQ SN60WF intraocular lenses (IOLs) and natural crystalline lenses in an age-matched population. Methods Sixty-nine eyes of 55 patients were examined. Group I included AcrySof spheric lenses, group II AcrySof aspheric lenses, and group III included patients with the natural crystalline lens. The HOA data were obtained with a LADARWave aberrometer (Alcon Inc.). Analysis was based on the RMS of coma, spherical aberrations (SA), and HOA. Statistical comparisons were performed with Kruskal Wallis variance analysis. Results In the case of coma, there were statistically significant differences between spheric and aspheric AcrySof (p<0.005) and between spheric AcrySof and natural crystalline lenses (p<0.005). The differences between aspheric AcrySof and natural crystalline lens group were not significant (p>0.05). SA were significantly different between spheric and aspheric AcrySof group, and spheric AcrySof and natural crystalline lens group (p<0.005), as well as between aspheric AcrySof and natural crystalline lens group (p<0.05). In case of HOA no significant differences were observed between aspheric AcrySof and natural crystalline lens group (p>0.05), but differences between groups AcrySof spheric and aspheric, and spheric AcrySof and natural crystalline lens, showed high significance (p<0.005). Conclusions The AcrySof Natural IQ aspheric model SN60WF IOL did not change the optical quality of vision compared to a healthy population of 60–80 years of age. The AcrySof Natural model SN60AT spherical IOL resulted in higher HOAs relative to both the natural crystalline lens population and eyes after aspheric AcrySof IQ model SN60WF IOL implantation.
Macular Sensitivity in Eyes with Central Serous Chorioretinopathy
Authors: Ozdemir H. , Senturk F. , Karacorlu M. , Arf Karacorlu S. , Uysal O. 
Published: January 2018

Purpose To determine macular sensitivity and fixation characteristics in eyes with central serous chorioretinopathy (CSC) using fundus-related microperimetry. Methods The authors reviewed 19 eyes with serous elevation within the central 10° due to CSC and 15 normal healthy eyes that had undergone fundus-related microperimetry. The macular sensitivity was measured using the fundus-related microperimeter, MP-1. The best-corrected visual acuity (BCVA), mean retinal sensitivity in the central 10° (central microperimetry, cMP-1) and in the paracentral 10° to 20° (paracentral microperimetry, pMP-1), and fixation stability and location were determined and compared with that of control eyes. Results Eyes with CSC showed significantly lower logMAR BCVA (p<0.001), cMP-1, and pMP-1 sensitivity than control eyes (p<0.001, p<0.01, respectively). Eyes with CSC were not significantly different in fixation location (p=1.00) or fixation stability than control eyes (p=0.45). Fixation location was predominantly central in all eyes with CSC; fixation was stable in 17 (89%) and relatively unstable in 2 (11%). Conclusions Eyes with CSC showed significantly lower retinal sensitivity not only at the central but also in the paracentral area. Even with decreased BCVA and retinal sensitivity, our patients showed central and stable fixation in their affected eyes.
Fetal Birthweight and Diastolic Blood Pressure: Association with Retinopathy in Severe Preeclampsia
Authors: Kaliaperumal S. , Setia S. , Gupta A. , Rao V.A. 
Published: January 2018

Purpose To find the association of retinopathy in preeclampsia with fetal birthweight and systolic and diastolic blood pressure (BP) in patients with mild and severe preeclampsia. Methods Medical records of patients with preeclampsia who delivered at term between January 2002 and December 2006 were included in the study Patients with preterm delivery, eclampsia, intrauterine fetal death, congenital defect in the fetus, and other systemic disorders were excluded. Parameters analyzed were retinopathy, systolic and diastolic BP, and fetal birthweight. Multivariable linear regression was used for statistical analysis. p value ≤0.05 was considered significant. Results The patients were divided into two groups: mild preeclampsia (MP) and severe preeclampsia (SP). The MP had 156 patients and SP had 104 patients. The mean systolic BP in MP and SP was 147.2 mmHg and 164.6 mmHg, while the mean diastolic BP in MP and SP was 98.6 mmHg and 112.7 mmHg. Severity of retinopathy was inversely associated with fetal birthweight (p=0.022) in SP, while it was insignificant in the MP (p=0.082). Low birthweight was due to intrauterine growth retardation of the fetus. Diastolic BP in the SP showed significant correlation with retinopathy (p=0.041). The systolic (p=0.55) and diastolic BP (p=0.248) in MP and systolic BP (p=0.803) in SP were insignificantly correlated with the retinopathy. Conclusions Retinopathy in preeclampsia may indirectly indicate the level of placental insufficiency and intrauterine growth retardation. The severity of retinopathy is more closely related with diastolic BP rather than systolic BP and the significance of this correlation increases in severe preeclampsia.
Cytomegalovirus Retinitis in the Absence of HIV or Immunosuppression
Authors: Sloan D.J. , Taegtmeyer M. , Pearce I.A. , Hart I.J. , Miller A.R.O. , Beeching N.J. 
Published: January 2018

Purpose Cytomegalovirus (CMV) retinitis classically occurs in advanced human immunodeficiency virus (HIV) infection but is rare in other forms of immunosuppression. The authors report a case of CMV retinitis in an HIV-negative man with idiopathic CD4 lymphocytopenia (ICL). This is the first such case to be confirmed by polymerase chain reaction (PCR) of aqueous humor. Methods Case report. Results A 69-year-old retired Chinese seaman presented with gradual visual deterioration. He was a diet controlled diabetic on regular steroids for presumed asthma. Examination showed no diabetic eye disease but confirmed acute retinal necrosis (ARN). Anterior chamber tapping of the aqueous humor was PCR positive for CMV. HIV antibody and RNA tests were negative but his full blood count revealed lymphocytopenia, with a low CD4+ subset. He responded to a 3-week course of intravenous ganciclovir therapy followed by suppressive oral valganciclovir. Conclusions CMV is associated with sight-threatening retinitis in HIV infection at CD4+ counts below 50 cells/μL and in transplant recipients or heavily immunosuppressed patients. Systemic steroids are a risk factor for clinical disease in these groups. It is extremely rare to report CMV eye disease in previously healthy individuals. This case illustrates that the condition does occur in association with ICL. Corticosteroids may be implicated in disease reactivation. Molecular methods are necessary to confirm the diagnosis.
Angle-Closure Glaucoma after Piggyback Intraocular Lens Implantation
Authors: García-Feijoo J. , Sáenz-Francés F , Martínez-De-La-Casa J.M. , Méndez-Hernández C. , Fernández-Vidal A. , Elías-De-Tejada M. , Reche-Frutos J. , García-Sánchez J. 
Published: January 2018

Purpose To report a case of angle closure glaucoma after piggyback intraocular lens implantation and its treatment. Methods The authors present the case of a 75-year-old woman who was seen in the emergency department with angle closure glaucoma. Two years before she had undergone piggyback intraocular lens (IOL) implantation in order to correct a refractive error after cataract surgery. Ultrasound biomicroscopy revealed a closed angle with synechiae in 360° as well as the presence of two IOLs: one in the capsular bag and the other in the ciliary sulcus. Extraction of the anterior IOL was precluded due to the poor endothelial count. Peripheral iridotomy and trabeculectomy were ineffective to lower the intraocular pressure (IOP); the authors decided to implant with an Ahmed valve and to place the valve's tube between the two IOLs to protect the endothelium. Results After Ahmed valve implantation, IOP maintains stable around 10–12 mmHg without medical treatment. Conclusions Ahmed valve implantation is a good option in angle closure glaucoma due to piggyback. The placement of the valve's tube between the two IOLs is a good option to protect corneal endothelium.
Laser in Situ Keratomileusis for Mixed Astigmatism Using a Modified Formula for Bitoric Ablation
Authors: De Ortueta D. , Haecker C. 
Published: January 2018

Purpose To evaluate the results of treatment of mixed astigmatism with laser in situ keratomileusis (LASIK) by means of a modified Chayet formula for bitoric ablation and personalized nomogram calculations. Methods A retrospective study was conducted in 19 consecutive eyes of 13 patients who underwent LASIK treatment of mixed astigmatism with a mean sphere of +1.63±1.23 D and a mean cylinder of −3.55±1.17 D. The authors used the Schwind ESIRIS Laser platform. The ablation was shifted from the pupil center to the vertex normal of the cornea. Results Three months postoperatively the mean sphere was 0.08±0.24 D and the mean astigmatism −0.45±0.31 D. At 3 months, an uncorrected visual acuity (UCVA) of 20/50 or better could be found in 100% of the eyes, and of 20/25 or better in 59%. All eyes were within ±0.5 D spherical equivalent (SE) at 3, 6, and 12 months. No eye lost more than one line of best spectacle-corrected visual acuity (BSCVA). Postoperatively, the corneal wavefront showed a reduction of spherical aberrations and coma, which were analyzed at 4 and 6 mm pupil diameter. The postoperative higher-order aberrations decreased at 4 mm and increased at 6 mm pupil sizes after surgery. Conclusions Modified bitoric treatment with the Schwind ESIRIS laser showed an excellent postoperative UCVA and BSCVA with applying external nomogram adjustments. The method demonstrated good predictability, safety, and effectiveness in the treatment of mixed astigmatism.
Management of Postkeratoplasty Ametropia: Intralasik after Penetrating Keratoplasty
Authors: Kucumen R.B. , Yenerel N.M. , Gorgun E. , Alimgil M.L. 
Published: January 2018

Purpose The authors describe a technique of laser in situ keratomileusis (LASIK) for the management of postkeratoplasty ametropia using a femtosecond laser for flap creation. Methods The first step was the placement of a disposable suction fixation ring to ensure that it was well-centered on the graft. The applanation cone was applied; the border of the flap was adjusted according to the edge of the graft. The hinge was at the 12 o'clock position; the mean flap diameter was 7.93 mm and the flap depth was 113.33 μm. The flap creation was made with the IntraLase femtosecond laser in a raster pattern. Twenty minutes after the flap creation, it was lifted and the treatment was completed with the Allegretto Wavelight excimer laser. Results Three patients were treated with this technique and no significant intraoperative or postoperative complications were observed. Conclusions IntraLASIK is a promising and accurate procedure for the correction of postkeratoplasty ametropia and astigmatism.
Serum Prolactin Levels in Hla-B27-Associated Uveitis
Authors: Proença H. , Ferreira C. , Miranda M. , Castanheira-Dinis A. , Monteiro-Grillo M. 
Published: January 2018

Purpose To evaluate basal serum prolactin levels in patients with HLA-B27-associated uveitis. Methods Prospective, nonrandomized comparative trial. Thirty-three patients with HLA-B27-associated uveitis and 30 age- and sex-matched healthy control subjects were included. Age, systemic disease, treatment, and uveitis activity were recorded for comparative analysis between groups. Fourteen out of 23 patients with arthritic disease had ankylosing spondylitis. Basal serum prolactin levels were determined by electrochemiluminescence immunoassay on a Modular Analytics E170 analyzer. Results Prolactinemia was significantly higher (mean=15.84 ng/mL) in patients vs controls (mean=11.50 ng/mL) (p=0.026). Subgroup analysis revealed prolactinemia in arthritic disease patients (mean=17.21 ng/mL) significantly higher than controls (mean=11.50 ng/mL) (p=0.009) and in ankylosing spondylitis (mean=17.65 ng/mL) vs controls (mean=11.50 ng/mL) (p=0.006). No correlation was found between prolactinemia and systemic treatment. Prolactinemia did not correlate with disease activity. Autoimmunity features also correlated with higher prolactinemia (mean=17.26 ng/mL) vs controls (mean=11.50 ng/mL) (p=0.015). Conclusions These results suggest the role of serum prolactin levels in HLA-B27-associated uveitis pathogenesis and its subgroups. There was no correlation with disease activity.