bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomography-based radiomics nomogram for prediction of lympho-vascular and perineural invasion in esophageal squamous cell cancer patients: a retrospective cohort study
Authors: Tang Bin , Wu Fan , Peng Lin , Leng Xuefeng , Han Yongtao , Wang Qifeng , Wu Junxiang , Orlandini Lucia Clara 
Published: October 2024

Abstract
Purpose
Lympho-vascular invasion (LVI) and perineural invasion (PNI) have been established as prognostic factors in various types of cancers. The preoperative prediction of LVI and PNI has the potential to guide personalized medicine strategies for patients with esophageal squamous cell cancer (ESCC). This study investigates whether radiomics features derived from preoperative contrast-enhanced CT could predict LVI and PNI in ESCC patients.

Methods and materials
A retrospective cohort of 544 ESCC patients who underwent esophagectomy were included in this study. Preoperative contrast-enhanced CT images, pathological results of PNI and LVI, and clinical characteristics were collected. For each patient, the gross tumor volume (GTV-T) and lymph nodes volume (GTV-N) were delineated and four categories of radiomics features (first-order, shape, textural and wavelet) were extracted from GTV-T and GTV-N. The Mann–Whitney U test was used to select significant features associated with LVI and PNI in turn. Subsequently, radiomics signatures for LVI and PNI were constructed using LASSO regression with ten-fold cross-validation. Significant clinical characteristics were combined with radiomics signature to develop two nomogram models for predicting LVI and PNI, respectively. The area under the curve (AUC) and calibration curve were used to evaluate the predictive performance of the models.

Results
The radiomics signature for LVI prediction consisted of 28 features, while the PNI radiomics signature comprised 14 features. The AUCs of the LVI radiomics signature were 0.77 and 0.74 in the training and validation groups, respectively, while the AUCs of the PNI radiomics signature were 0.69 and 0.68 in the training and validation groups. The nomograms incorporating radiomics signatures and significant clinical characteristics such as age, gender, thrombin time and D-Dimer showed improved predictive performance for both LVI (AUC: 0.82 and 0.80 in the training and validation group) and PNI (AUC: 0.75 and 0.72 in the training and validation groups) compared to the radiomics signature alone.

Conclusion
The radiomics features extracted from preoperative contrast-enhanced CT of gross tumor and lymph nodes have demonstrated their potential in predicting LVI and PNI in ESCC patients. Furthermore, the incorporation of clinical characteristics has shown additional value, resulting in improved predictive performance.
High levels of bisphenol A among infertile men can impair spermatogenesis by oxidative stress and elevated levels of microRNA-337
Authors: Ahmad Manar A. , Ismail Nashaat Nabil , Ghaleb Sherien S. , Hassan Dalia Abd Elwhab , Al-Fakharany Reham S. , Ghoneim Mohammed M. , Ahmed Amany M. , Lotfy Amr Mohamed , AboSief Ahmed Fathy Mohamed 
Published: October 2024

Abstract
Background
Studies have shown that Bisphenol A may interfere with the process of spermatogenesis and result in a decrease in the quality of semen. Nevertheless, the fundamental processes remain unclear. This study was done to investigate the connections between exposure to Bisphenol A, spermatogenesis with microRNA-337, and malondialdehyde in infertile men.

Methods
This study was a case–control study on 73 participants. Infertile group (1a): azoospermia (n = 16), infertile group (1b): oligozoospermia (n = 22), and control group (2): normospermic (n = 35) were enrolled in this study. Full history, local examination, semen analysis, and urine and blood samples were taken from all participants. Urinary Bisphenol A, malondialdehyde, and serum microRNA-337 were measured.

Results
The mean Bisphenol A level in azoospermia group shows statistically significant increase comparing to fertile control group. The mean microRNA-337 level in oligozoospermia and azoospermia group shows statistically significant increase comparing to fertile controls. The mean malondialdehyde level in infertility groups shows statistically significant increase comparing to fertile control group. No linear correlations were recorded between Bisphenol A levels with semen quality parameters, hormonal profile, and microRNA-337.

Conclusion
While there is no significant change in the levels of Bisphenol A between normal fertile males and infertile males with oligozospermia, a significant elevation in the BPA level was observed in infertile males with azoospermia. A significant upregulation of the miRNA-337 gene expression in infertile males either oligozospermia or azoospermia was also observed. In addition, lipid peroxidation as evident by the significant elevation of MDA levels was marked among infertile patients.
Anesthesia for Posterior Tracheopexy in Pediatric Patients
Authors: Muñoz Carlos J. , Kuo Frederick H. , Hernández Michael R. , Alrayashi Walid , Sullivan Cornelius A. , Wang Jue T. , Jennings Russell W. 
Published: October 2024

Tracheobronchomalacia refers to an abnormally excessive collapse of the trachea and/or bronchi during exhalation. In the pediatric population, tracheobronchomalacia is increasingly recognized as a cause of morbidity and mortality. Historically, options for medical management and surgical intervention were limited, and patient outcomes were poor.
Over the last decade, select US pediatric institutions have devoted significant resources to the establishment of dedicated surgery and anesthesia teams and the development of novel techniques for the successful identification, assessment, and surgical correction of tracheobronchomalacia in a highly complex subset of the pediatric population. The close communication, collaboration, and evolution of anesthesia techniques to meet the unique requirements of new surgical procedures have greatly improved patient safety and optimized outcomes. More than 800 cases have been performed across 2 US pediatric institutions using these techniques. This article reviews the posterior tracheopexy procedure, a newer but increasingly common surgery designed to address tracheobronchomalacia, and provides an overview of related anesthesia considerations and unique challenges. In addition, this article describes novel anesthesia techniques developed specifically to facilitate optimal diagnosis of tracheobronchomalacia and intraoperative management of posterior tracheopexy and similar airway surgeries. These include methods to safely enable 3-phase rigid dynamic bronchoscopy for accurate tracheobronchomalacia diagnosis, recurrent laryngeal nerve monitoring during cervical and thoracic surgical dissection, continuous intraoperative bronchoscopy to enable real-time images during airway reconstruction, and intraoperative assessment of airway repair adequacy to ensure successful correction of tracheobronchomalacia.
Implications in dental treatment during the use of antiresorptive drugs - a literature review
Authors: Dziewulska Aleksandra , Kiełt Weronika , Kozłowska Julia , Broniec Gabriela , Wajdowicz Barbara , Kudła Aleksandra , Czapiewska Rozalia , Wróbel Aleksandra , Pacek Laura , Kowalska Klaudia 
Published: October 2024

Introduction: Antiresorptive drugs such as bisphosphonates and denosumab are crucial for treating osteoporosis, metastatic bone disease, and hypercalcemia by inhibiting osteoclast function. They can lead to medication-related osteonecrosis of the jaw (MRONJ) following invasive dental procedures, requiring careful management to mitigate potential adverse effects.
Purpose of work: Synthesis of knowledge about the impact of taking antiresorptive drugs on aspects of dental treatment.
Materials and methods: Materials used in this study were found in the PubMed and Google Scholar database, using the following key words “antiresorptives”, “bisphosphonates”, “dental treatment”, “osteonecrosis of the jaw”
Summary: Antiresorptive drugs like bisphosphonates and denosumab are essential for managing osteoporosis and other bone diseases but pose challenges in dental care, notably with risks such as medication-related osteonecrosis of the jaw (MRONJ). These medications influence treatment strategies across orthodontics, implantology, periodontal therapy, and endodontics, necessitating careful management to balance therapeutic benefits with potential dental complications.
Possible advantages of sodium induced hyperhydration before physical activity
Authors: Mączka Jakub , Pyc Grzegorz , Kowalewski Jan , Dąbrowska Aleksandra , Bęben Damian , Dudzik Maria , Majewski Kornel , Pakos Kinga , Durmała Kamila , Sielicka Urszula 
Published: October 2024

Introduction and objective:
Athlete’s performance depends both on training and nutrition. Although athletes analyze macronutrients intake, micronutrients are often omitted, with sodium among them. It is proven to boost performance, due to its hydrating qualities. The aim of this study is to explore positive effects of salt induced hyperhydration, its effect on muscle cramps, exercise associated hyponatremia, prevention of dehydration and possible endurance gain.
Purpose of the study: The aim of this study is to look further into the positive effects of sodium loading induced hyperhydration, its effect on muscle cramps, exercise associated hyponatremia, prevention of dehydration and possible endurance gain using PubMed databases from the last 25 years.

Review methods:
Articles were searched by entering keywords in PubMed databases. Scientific articles written from 2016 to 2024 make up 76% of the literature. Guidelines from global societies of dietary health and sport. Studies from specialized research centers including meta-analyses and double-blind randomized trials were included. Ones conducted with methodological errors were rejected.

Basic results and conclusions:
We can draw a conclusion that salt-loading might indeed prove useful in endurance training preparation, and should be included in an athlete's supplements arsenal. Dehydrating nature of heat and long training make salt induced hyperhydration more efficient in such conditions. Sportsmen can improve results in both endurance performance and reduction of the occurrence of possible negative outcomes connected with metabolic and physical strain. Presented studies also advocate for the importance of sodium loading in prevention of hyponatremia and muscle cramps.
The applicability of the Teachers' Inclusive Education Attitude Scale on Chinese preservice physical education teachers
Authors: Wei Qian , Luo Changxin , Li Yun 
Published: October 2024

Purpose: This study aims to translate and culturally adapt the revised The Teachers' Attitudes Towards Inclusion Scale Adjusted (TAISA) into Chinese and to evaluate its reliability and validity among Chinese preservice physical educators.
Methodology: The English version of The Teachers' Attitudes Towards Inclusion Scale Adjusted (TAISA) was translated through a rigorous process that included a comprehensive literature review and consultations with subject matter experts. A survey was administered to 500 preservice physical educators in Chongqing. The adapted scale underwent thorough analysis, encompassing demographic frequency analysis, item analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and evaluation of test-retest reliability.
Results: The analysis revealed that the Chinese version of The Teacher Attitude toward Inclusive Education Scale for Preservice Physical Educators (TAISA-P) retained the original three-factor structure, comprising positive affect, training and perceived competence, and negative affect. After the removal of four items, the final scale consisted of 17 items, with each dimension containing 5 to 6 items. Factor loadings ranged from 0.442 to 0.705, and the model demonstrated a χ²/df ratio of 1.350, a root mean square error of approximation (RMSEA) of 0.066, a non-normed fit index (NNFI) of 0.825, a comparative fit index (CFI) of 0.946, an incremental fit index (IFI) of 0.948, and a goodness-of-fit index (GFI) of 0.834. The overall internal consistency reliability of TAISA-P was 0.759, with dimension-specific reliabilities of 0.835, 0.790, and 0.779. The test-retest reliability coefficient was 0.743 (P < 0.001).
Conclusion: The Teacher Attitude toward Inclusive Education Scale for Preservice Physical Educators (TAISA-P) demonstrates strong reliability and validity, thereby establishing it as a suitable instrument for assessing the attitudes of Chinese preservice physical educators toward inclusive education.
Quality of Life in Primary Biliary Cholangitis - Advances in the Treatment
Authors: Kuzio Agnieszka , Cieplińska Aleksandra , Jama Grzegorz , Ziojła-Lisowska Kinga , Pliszka Marzena , Piasecka Zuzanna , Haczkur-Pawłowska Karolina , Borowiak Maciej , Kolano Patrycja , Karnas-Bogacka Patrycja 
Published: October 2024

Primary sclerosing cholangitis (PSC) is an inflammatory, cholestatic and progressively fibrotic liver disease devoid of effective medical intervention. PBC is a presumed immune-mediated liver disease of middle-aged women associated with significant morbidity and mortality. People living with PBC are frequently symptomatic, experiencing a quality-of-life burden dominated by fatigue, itch, abdominal pain, and sicca complex. Many drugs have been studied for treatment, including agents with choleretic and immunosuppressive properties. Future PBC licensed therapy will likely include peroxisome proliferator activated receptor (PPAR) pathway agonists, including specific PPAR-delta agonism (seladelpar), as well as elafibrinor and saroglitazar (both with broader PPAR agonism). Effective therapy reduces the need for transplantation and improves life expectancy.
How EFL teachers perceive and self-evaluate the knowledge components in forming Technological Pedagogical Content Knowledge (TPACK)
Authors: Shi Leimin , Jiang Lili 
Published: October 2024

Technology is widely involved across the learning environment including its integration into teaching English as a foreign language (EFL); however, few studies have explored EFL teachers’ perceptions of technological pedagogical content knowledge (TPACK). This study investigates how EFL teachers perceive and self-evaluate knowledge of content (CK), pedagogy (PK), and technology (TK), the interplay of these with each other (TPACK), and the underlying influential factors for TPACK construction. The data were gathered in China from an online survey (n = 64) comprising 35 items on the TPACK components, and self-evaluation by nine survey participants of their TPACK in follow-up interviews. WeChat, the most popular social media App in China, was utilised as the data collection tool. The survey reveals teachers’ strong beliefs in the value of PK, CK and PCK and their positive beliefs about technological applications in EFL instruction. Consistent with these results, interviewees’ self-evaluation of TPACK demonstrates that they felt a high level of confidence in CK, PK and PCK but relatively less confidence when technology was integrated despite commonly applying technology to instruction. Influential factors include: 1) contextual factors; 2) knowledge of students; 3) demographic background; and 4) availability of quality training. Decision-makers’ financial support and policy-making, technological training in the integration of CK and/or PK, and a collaborative learning strategy are recommended.
CoGTEx: Unscaled system-level coexpression estimation from GTEx data forecast novel functional gene partners
Authors: Cortes-Guzman Miguel-Angel , Treviño Víctor 
Published: October 2024

Motivation
Coexpression estimations are helpful for analysis of pathways, cofactors, regulators, targets, and human health and disease. Ideally, coexpression estimations should consider as many diverse cell types as possible and consider that available data is not uniform across tissues. Importantly, the coexpression estimations accessible today are performed on a “tissue level”, which is based on cell type standardized formulations. Little or no attention is paid to overall gene expression levels. The tissue-level estimation assumes that variance expression levels are more important than mean expression levels. Here, we challenge this assumption by estimating a coexpression calculation at the “system level”, which is estimated without standardization by tissue, and show that it provides valuable information. We made available a resource to view, download, and analyze both, tissue- and system-level coexpression estimations from GTEx human data.

Methods
GTEx v8 expression data was globally normalized, batch-processed, and filtered. Then, PCA, clustering, and tSNE stringent procedures were applied to generate 42 distinct and curated tissue clusters. Coexpression was estimated from these 42 tissue clusters computing the correlation of 33,445 genes by sampling 70 samples per tissue cluster to avoid tissue overrepresentation. This process was repeated 20 times, extracting the minimum value provided as a robust estimation. Three metrics were calculated (Pearson, Spearman, and G-statistic) in two data processing modes, at the system-level (TPM scale) and tissue levels (z-score scale).

Results
We first validate our tissue-level estimations compared with other databases. Then, by specific analyses in several examples and literature validations of predictions, we show that system-level coexpression estimation differs from tissue-level estimations and that both contain valuable information reflected in biological pathways. We also show that coexpression estimations are associated to transcriptional regulation. Finally, we present CoGTEx, a valuable resource for viewing and analyzing coexpressed genes in human adult tissues from GTEx v8 data. We introduce our web resource to list, view and explore the coexpressed genes from GTEx data.

Conclusion
We conclude that system-level coexpression is a novel and interesting coexpression metric capable of generating plausible predictions and biological hypotheses; and that CoGTEx is a valuable resource to view, compare, and download system- and tissue- level coexpression estimations from GTEx data.

Availability
The web resource is available at http://bioinformatics.mx/cogtex.
Arreta partekatzen Pepper robot sozialarekin
Authors: Samaniego Miren , Rodriguez Igor , Lazkano Elena 
Published: October 2024

Robot sozialek arreta soziala erakutsi behar dute eta, horretarako, ezinbestekoa da gizaki(ar)ekin elkarrekintzan ari denean intereseko objektua detektatzeko gaitasuna. Lan honetan, pertsonak begiradaren bidez fokatzen duen objektua identifikatu eta lokalizatzeko sistema garatu da eta baita Pepper robotean integratu ere. YOLOv8 erabili da irudi bidez pertsona detektatu eta bere aurpegia lokalizatzeko. Begiradaren fokua lortzeko VGG16 neurona sare konboluzionala entrenatu da, erregresio moduan, emaitza onargarriak erakutsiz. Eredu honen erantzunak bero mapa batean bihurtu eta sakoneraren informazioarekin konbinatuz, ResNet101 sareak emango digu azken erantzuna: begiradaren gunea non den eta zer den. Portaera hau robotera eraman da eta arreta konpartitua erakusteko robotak objektu berari begiratzeko mugimendua gauzatzen du erabiltzaileari ahoz odu egokian erantzuteko. Era honetan, erabiltzaileari arreta partekatuaren sensazioa transmititzen zaio. Bideo batean erakusten da portaera orokorraren emaitza.
Le Dauphin ontziaren euskarazko gutuneriaz (Baiona, 1757)
Authors: Videgain Xarles 
Published: October 2024

Xabier Lamikizek egin zuen presari esker dator Le Dauphin ontziak zeraman gutuneriaren aurkezpena. 1757an Baionatik Louisbourgera joateko zen Le Dauphin Ingalaterrako ontzidiaren presa izan zen eta haren barnean zegoen dokumentazioa ediren zuen X. Lamikizek Londreseko artxiboetan. Lapurdiko gutun-igorleek (gehienetan emazte) lapurteraz idatzitako 50 gutun Louisbourgeko hartzaileei igorri zizkieten. Euskararen historiarentzat lekukotasun nagusi dela ageri da. Orduko Zazpi Urtetako Gerla, Baionako kortsu jardunaldia eta Louisbourgeko ekonomia aipatu ondoan, gutunen pasarte labur batzuk ematen dira, edozein gutunek betetzen ohi dituen funtzioen, berri franko ematen digutelo orduko jendeen bizimoduaz. X. Elosegik gutunen protagonistei buruz bildu duenaz ere parte ematen da: laguntza ekonomikoa eskatzen edo eskaintzen dute igorleek, hasarrea adierazten dute hartzailea ez delakoan ongi portatu edo bere buruaren berririk ez duelako ematen, eta oroz gainetik hartzailea otoizten dute Euskal Herrira itzul dadin ahal bezain laster : « Zato, zato etxera ». Azkenik, indarrean dagoen proiektuak ideki behar dituen ildoak aipatzen dira.
Black American Agricultural Experts and the Vernacularization of American Science in Liberia Prior to Decolonization in Africa
Authors: Mark-Thiesen Cassandra 
Published: October 2024

Abstract
Studies continue to assume an unbridgeable gap between scientific representations and ontological realities in Africa. Histories of foreign scientific interventions on the continent have often emphasized the role of scientists as agents of empire. However, there is a growing body of historiography that explores how adaptation and translation took place against the backdrop of the massive power imbalances that characterized such knowledge transfers, including in relation to the complex and shifting positions of the scientists themselves. This article focuses on black American agricultural scientists who advised the Liberian government on how to grow surplus crops nationally. It examines their practice of linking science to local knowledge. It also explores their personal negotiations with American empire as they infused their work with black internationalist theories of liberation and racial uplift. By looking at scientists on the ground or in the field, we can learn more about embedded processes of epistemic and political negotiation and critique.
A Review: Classification, Chemical Compositions and Antioxidant Properties of Red, Brown and Green Macroalgae
Authors: Nguyen Ngoc Trang Thuy , Tran Thanh Men 
Published: October 2024

In human body, free radicals cause oxidative stress which is reported to be the main reason of many life style human diseases. This stress induced by the imbalance of antioxidants and oxidants. Many deadly diseases induced by oxidative stress as it forms the root cause of several degenerative changes in the cells and tissues. Nucleic acids, lipids and proteins in our body are demaged by this stress, made changes to cellular functions and lead to apoptosis or necrosis. Antioxidants have an important role in protection human body from oxidative damages and prevention of many chronic diseases, for example, diabetes, cardiovascular disease, aging, even diseases related to the nervous system. Currently, the exploration of natural antioxidants is trends in the pharmaceutical industries because synthetic antioxidants are reported to cause major side effects. Antioxidants of natural origin are considered safe and highly effective. These substances are abundant in many medicinal herbs including algae, fungi, plants and animals. Among them, seaweed is believed to be a potential source of medicinal herbs capable of synthesizing compounds with good biological activity. Off these, macroalgae, including red, brown, and green macroalgae, are considered a natural source of antioxidant components that can provide a valuable contribution to the innovation of pharmaceutical and industrial fields. Since algal products' antioxidant properties and nutritional benefits have been increasingly recognized, their properties as antioxidants require further investigative studies. This review provides information on various aspects of antioxidants, including algal sources containing antioxidants, the chemical composition of macroalgae, and antioxidant components, as well as their benefits to human health.