bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases
Authors: Adogwa Owoicho , Elsamadicy Aladine A. , Sergesketter Amanda , Vuong Victoria D. , Mehta Ankit I. , Vasquez Raul A. , Cheng Joseph , Bagley Carlos A. , Karikari Isaac O. 
Published: June 2017

OBJECTIVEWound infections following spinal surgery for deformity place a high toll on patients, providers, and the health care system. The prophylactic application of intraoperative vancomycin powder has been shown to lower the infection risk after thoracolumbar decompression and fusion for deformity correction. The purpose of this study was to assess the microbiological patterns of postoperative surgical site infections (SSIs) after prophylactic use of vancomycin powder in adult patients undergoing spinal deformity surgery.METHODSAll cases involving adult patients who underwent spinal deformity reconstruction at Duke University Medical Center between 2011 and 2013 with a minimum of 3 months of clinical follow-up were retrospectively reviewed. In all cases included in the study, crystalline vancomycin powder was applied to the surgical bed for infection prophylaxis. Baseline characteristics, operative details, rates of wound infection, and microbiological data for each case were gathered by direct medical record review.RESULTSA total of 1200 consecutive spine operations were performed for deformity between 2011 and 2013. Review of the associated records demonstrated 34 cases of SSI, yielding an SSI rate of 2.83%. The patients’ mean age (± SD) was 62.08 ± 14.76 years. The patients’ mean body mass index was 30.86 ± 7.15 kg/m2, and 29.41% had a history of diabetes. The average dose of vancomycin powder was 1.41 ± 2.77 g (range 1–7 g). Subfascial drains were placed in 88% of patients. All SSIs occurred within 30 days of surgery, with deep wound infections accounting for 50%. In 74% of the SSIs cultures were positive, with about half the organisms being gram negative, such as Citrobacter freundii, Proteus mirabilis, Morganella morgani, and Pseudomonas aeruginosa. There were no adverse clinical outcomes related to the local application of vancomycin.CONCLUSIONSOur study suggests that in the setting of prophylactic vancomycin powder use, the preponderance of SSIs are caused by gram-negative organisms or are polymicrobial. Further randomized control trials of prophylactic adjunctive measures are warranted to help guide the choice of empirical antibiotic therapy while awaiting culture data.
Online appendix 1: A new checklist of lichenised, lichenicolous and allied fungi reported from South Africa
Authors: Fryday Alan M. 
Published: June 2017

Background: The last comprehensive list of lichenised, lichenicolous and allied fungi reported from South Africa was published in 1950. A checklist is important to provide basic information on the extent of the diversity, and to provide the most recent name and classification.Objective: To present a list of all the lichenised, lichenicolous and allied fungi reported from South Africa.Methods: The list presented is entirely literature based and no attempt has been made to check the report of any taxa or their status by checking the specimens upon which they are based. Firstly, all taxa that were not reported from within the modern boundaries of South Africa were excluded. Next, the Recent literature on lichens database was searched for literature on South African lichens since 1945 and all references checked for new species or new reports, which were then added to the list. These names were then checked against Index Fungorum to ensure that the most current name was being used. Finally, the list was rationalised by excluding all synonyms and dubious infraspecific taxa.Results: The current list includes 1750 taxa in 260 genera from mainland South Africa, with an additional 100 species and 23 genera from the sub-Antarctic Prince Edward Islands, which are treated separately. The replacement name Verrucaria dagolavii Fryday is proposed for Verrucaria umbilicata Øvstedal.Conclusion: It is estimated that, when fully explored, the lichen biota of South Africa will consist of somewhere between 2500 and 3000 taxa.
Are precipitation anomalies associated with aerosol variations over eastern China?
Authors: Xu Xiangde , Guo Xueliang , Zhao Tianliang , An Xingqin , Zhao Yang , Quan Jiannong , Mao Fei , Gao Yang , Cheng Xinghong , Zhu Wenhui , Wang Yinjun 
Published: June 2017

Abstract. In eastern China (EC), the strong anthropogenic emissions deteriorate the atmospheric environment, building a south–north zonal distribution of high aerosols harbored by the upstream Tibetan and Loess plateaus in China. This study climatologically analyzed the interannual variability in precipitation with different intensities in association with aerosol variations over the EC region from 1961 to 2010 by using precipitation and visibility data from more than 50 years and aircraft and surface aerosol data from recent years in China, and the impacts of aerosol variations on interannual variability in the intensity of precipitation events and their physical causes are investigated. We found that the frequency of light rain has significantly decreased and the occurrence of rainstorms, especially severe rainstorms, has significantly increased over recent decades. The extreme precipitation events presented an interannual variability pattern similar to that of the frequent haze events over EC. Accompanied by the frequent haze events in EC, light rain frequency significantly decreased and extremely heavy precipitation events have occurred more frequently. During the 1980s, the regional precipitation trends in EC showed an obvious transform from more light rain to more extreme rainstorms. The running correlation analysis of interdecadal variation further verified that the correlation between the increasing aerosols and frequencies of abnormal precipitation events tended to be more significant in EC. The correlation between atmospheric visibility and low cloud amounts, which are both closely related to aerosol concentrations, was positive in the north and negative in the south, and the spatial distribution of the variability in regional rainstorm frequency was positive in the south and negative in the north. After the 1990s, the visibility in summer season deteriorated more remarkably, light rain frequency decreased noticeably, and rainstorms and extraordinarily heavy rainfall occurred more frequently. There were significant differences in the interdecadal variation trends in light rain and rainstorm events between the highly aerosol-polluted area in EC and the relatively clean area on the western plateaus of China. The aircraft measurements over EC confirmed that the diameters of cloud droplets decreased under high aerosol concentration conditions, thereby inhibiting weak precipitation process.
Climate and basin drivers of seasonal river water temperature dynamics
Authors: Laizé Cédric L. R. , Bruna Meredith Cristian , Dunbar Michael J. , Hannah David M. 
Published: June 2017

Abstract. Stream water temperature is a key control of many river processes (e.g. ecology, biogeochemistry, hydraulics) and services (e.g. power plant cooling, recreational use). Consequently, the effect of climate change and variability on stream temperature is a major scientific and practical concern. This paper aims (1) to improve the understanding of large-scale spatial and temporal variability in climate–water temperature associations, and (2) to assess explicitly the influence of basin properties as modifiers of these relationships. A dataset was assembled including six distinct modelled climatic variables (air temperature, downward short-wave and long-wave radiation, wind speed, specific humidity, and precipitation) and observed stream temperatures for the period 1984–2007 at 35 sites located on 21 rivers within 16 basins (Great Britain geographical extent); the study focuses on broad spatio-temporal patterns, and hence was based on 3-month-averaged data (i.e. seasonal). A wide range of basin properties was derived. Five models were fitted (all seasons, winter, spring, summer, and autumn). Both site and national spatial scales were investigated at once by using multi-level modelling with linear multiple regressions. Model selection used multi-model inference, which provides more robust models, based on sets of good models, rather than a single best model. Broad climate–water temperature associations common to all sites were obtained from the analysis of the fixed coefficients, while site-specific responses, i.e. random coefficients, were assessed against basin properties with analysis of variance (ANOVA). All six climate predictors investigated play a role as a control of water temperature. Air temperature and short-wave radiation are important for all models/seasons, while the other predictors are important for some models/seasons only. The form and strength of the climate–stream temperature association vary depending on season and on water temperature. The dominating climate drivers and physical processes may change across seasons and across the stream temperature range. The role of basin permeability, size, and elevation as modifiers of the climate–water temperature associations was confirmed; permeability has the primary influence, followed by size and elevation. Smaller, upland, and/or impermeable basins are the most influenced by atmospheric heat exchanges, while larger, lowland and permeable basins are the least influenced. The study showed the importance of accounting properly for the spatial and temporal variability of climate–stream temperature associations and their modification by basin properties.
Sensitivity analysis and calibration of a dynamic physically based slope stability model
Authors: Zieher Thomas , Rutzinger Martin , Schneider-Muntau Barbara , Perzl Frank , Leidinger David , Formayer Herbert , Geitner Clemens 
Published: June 2017

Abstract. Physically based modelling of slope stability on a catchment scale is still a challenging task. When applying a physically based model on such a scale (1 : 10 000 to 1 : 50 000), parameters with a high impact on the model result should be calibrated to account for (i) the spatial variability of parameter values, (ii) shortcomings of the selected model, (iii) uncertainties of laboratory tests and field measurements or (iv) parameters that cannot be derived experimentally or measured in the field (e.g. calibration constants). While systematic parameter calibration is a common task in hydrological modelling, this is rarely done using physically based slope stability models. In the present study a dynamic, physically based, coupled hydrological–geomechanical slope stability model is calibrated based on a limited number of laboratory tests and a detailed multitemporal shallow landslide inventory covering two landslide-triggering rainfall events in the Laternser valley, Vorarlberg (Austria). Sensitive parameters are identified based on a local one-at-a-time sensitivity analysis. These parameters (hydraulic conductivity, specific storage, angle of internal friction for effective stress, cohesion for effective stress) are systematically sampled and calibrated for a landslide-triggering rainfall event in August 2005. The identified model ensemble, including 25 behavioural model runs with the highest portion of correctly predicted landslides and non-landslides, is then validated with another landslide-triggering rainfall event in May 1999. The identified model ensemble correctly predicts the location and the supposed triggering timing of 73.0 % of the observed landslides triggered in August 2005 and 91.5 % of the observed landslides triggered in May 1999. Results of the model ensemble driven with raised precipitation input reveal a slight increase in areas potentially affected by slope failure. At the same time, the peak run-off increases more markedly, suggesting that precipitation intensities during the investigated landslide-triggering rainfall events were already close to or above the soil's infiltration capacity.
Winter mass balance of Drangajökull ice cap (NW Iceland) derived from satellite sub-meter stereo images
Authors: Belart Joaquín M. C. , Berthier Etienne , Magnússon Eyjólfur , Anderson Leif S. , Pálsson Finnur , Thorsteinsson Thorsteinn , Howat Ian M. , Aðalgeirsdóttir Guðfinna , Jóhannesson Tómas , Jarosch Alexander H. 
Published: June 2017

Abstract. Sub-meter resolution, stereoscopic satellite images allow for the generation of accurate and high-resolution digital elevation models (DEMs) over glaciers and ice caps. Here, repeated stereo images of Drangajökull ice cap (NW Iceland) from Pléiades and WorldView2 (WV2) are combined with in situ estimates of snow density and densification of firn and fresh snow to provide the first estimates of the glacier-wide geodetic winter mass balance obtained from satellite imagery. Statistics in snow- and ice-free areas reveal similar vertical relative accuracy (<  0.5 m) with and without ground control points (GCPs), demonstrating the capability for measuring seasonal snow accumulation. The calculated winter (14 October 2014 to 22 May 2015) mass balance of Drangajökull was 3.33 ± 0.23 m w.e. (meter water equivalent), with ∼ 60 % of the accumulation occurring by February, which is in good agreement with nearby ground observations. On average, the repeated DEMs yield 22 % less elevation change than the length of eight winter snow cores due to (1) the time difference between in situ and satellite observations, (2) firn densification and (3) elevation changes due to ice dynamics. The contributions of these three factors were of similar magnitude. This study demonstrates that seasonal geodetic mass balance can, in many areas, be estimated from sub-meter resolution satellite stereo images.
Incidence and Evolution of Subretinal Precipitates in Optic Disc Pit Maculopathy
Authors: Chatziralli Irini , Theodossiadis George , Brouzas Dimitrios , Theodossiadis Panagiotis 
Published: June 2017

Purpose To study the evolution of subretinal precipitates coexistent with optic disc pit (ODP) maculopathy from their appearance at baseline examination until their absorption after successful treatment. Methods Participants in this retrospective, multicenter study were 42 patients with ODP maculopathy, in whom complete ocular examination was performed, including visual acuity (VA) measurement, slit-lamp examination, color or red-free fundus photography, and optical coherence tomography at baseline after surgical treatment. Results Out of 42 cases, 17 (40.5%) cases of ODP maculopathy, which were examined between 2002 and 2015, were found to have subretinal precipitates associated with multilayer fluid accumulation at baseline. Precipitates were located at the outer part of the photoreceptor layer and remained for 3-6 months after successful treatment and absorption of subretinal fluid. The mean VA was 0.99 ± 0.21 logMAR at baseline and improved to 0.54 ± 0.25 logMAR at the final examination. Conclusions Macular precipitates in association with signs of disease chronicity, such as multilayer fluid accumulation, became evident at baseline examination. Precipitates’ disappearance in 15 out of 17 cases coincided with the absorption of subretinal fluid. The relative low VA at baseline probably could be attributed to the chronicity of the disease.
Effect of Artificial Saliva with Different pH Levels on the Cytotoxicity of Soft Denture Lining Materials
Authors: Akay Canan , Taniş Merve Ç. , Sevim Handan 
Published: June 2017

Background The aim of this study was to evaluate the cytotoxic effects of 9 different soft denture liners on the viability of L-929 mouse fibroblast cells at different incubation periods by storing them in artificial saliva (AS) with different pH levels. Methods 96 disk samples from each lining material were prepared and divided into 4 groups: GI: No treatment; GII: Stored in artificial saliva with pH 3 for 21 days; Group III: Stored in artificial saliva with pH 7 for 21 days; and Group IV: Stored in artificial saliva with pH 14 for 21 days. The cytotoxicity of the extracts to cultured mouse fibroblasts (L-929) was measured by MTT (tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-dipHnyltetrazolium bromide) assay. Data were analyzed using 1-way analysis of variation (ANOVA). Results It was found that for the pH 3 values of New Truliner, Trusoft, Mollosil Plus, Dentusil, TDV, and HydroCast®; for the pH 7 values of Ufi Gel P and Elite plus; and for the pH 14 values of HydroCast®, there was a noncytotoxic effect during both the 24-hour and 48-hour incubation periods. In the control group 48-hour incubation period, HydroCast®, TDV, Mollosil, 24-hour incubation period Elite plus, for pH 3 values; Elite Plus 24-hour incubation period, for pH 7 values Trusoft 48-hour incubation period there was a moderately cytotoxic effect. Conclusions This in vitro study revealed that storage in artificial saliva with different pH levels can affect the cytotoxicity of soft lining materials.
High Expression of IL-4R Enhances Proliferation and Invasion of Hepatocellular Carcinoma Cells
Authors: Guo Changkuo , Ouyang Yuming , Cai Jing , Xiong Le , Chen Yajie , Zeng Xiaoli , Liu Anwen 
Published: June 2017

Objective In this study, we aimed to investigate the expression and function of interleukin-4 receptor (IL-4R) in hepatocellular carcinoma (HCC). Methods We collected 40 pairs of human HCC and adjacent normal tissue specimens and examined the expression levels of IL-4R. After IL-4R knockdown in HCC cell lines, cell proliferation and invasion ability were examined. Cell cycle and apoptosis were analyzed by flow cytometry. The activity of multiple signaling pathways was examined by Western blot. Results IL-4R was overexpressed in HCC tumors compared with adjacent normal control tissues and was associated with tumor differentiation status. IL-4R knockdown resulted in enhanced apoptosis, impaired proliferation and reduced invasion of HCC cells. Furthermore, IL-4R knockdown abolished IL-4-induced activation of the Janus Kinase 1 (JAK1)/signal transducer and activator of transcription 6 (STAT6) and JUN N-terminal kinase (JNK)/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways. Conclusions IL-4R plays an important role in regulating HCC cell survival and metastasis, and regulates the activity of the JAK1/STAT6 and JNK/ERK1/2 signaling pathways. We therefore suggest that IL-4/IL-4R may be a new therapeutic target for HCC.
Ischemic Monomelic Neuropathy: A Long-Term follow-up of Two Cases
Authors: Singh Vikas , Qaisar Huzaif , Masud Avais , Mehandru Sushil , Sadiang-Abay Elmer , Costanzo Eric J. , Salman Loay 
Published: June 2017

Introduction Ischemic monomelic neuropathy (IMN) is the most dreaded complication of an arteriovenous access creation. While uncommon, it can lead to pain, paresthesia or/and hand weakness. Creation of an arteriovenous connection causing a sudden diversion of blood away from the nerves can lead to ischemic injury to the neural tissue and cause IMN. Immediate surgical ligation has been traditionally recommended to limit ongoing neural tissue injury. Case description We present two diabetic patients who developed IMN after the creation of a left upper extremity brachial-cephalic fistula and refused to undergo surgical ligation. The clinical examination revealed paresthesia localized to the volar aspect of the left forearm with mild weakness of the thumb, index and middle finger. Rehabilitation therapy was initiated in both and revealed a significant improvement in weakness but paresthesia persisted. Fistula maturation was achieved in both patients with an access flow of 1100-1200 cc/min. At 4 months, fistula was used successfully for dialysis in both patients. At a follow-up of 11 months, hand weakness did not progress and paresthesia disappeared. Conclusions These cases demonstrate sensory-motor improvement with time and rehabilitation therapy and challenge the traditional approach of fistula ligation. The approach presented in this paper also results in the preservation of the lifeline of a patient. Future investigations should focus on identifying candidates who could benefit from physical therapy and rehabilitation.
Effect of delayed radical cystectomy for invasive bladder tumors on lymph node positivity, cancer-specific survival and total survival
Authors: Türk Hakan , Ün Sıtkı , Cinkaya Ahmet , Kodaz Hilmi , Parvizi Murtaza , Zorlu Ferruh 
Published: June 2017

Introduction: Radical cystectomy (RC) is the main treatment option for patients with muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC), which carry the highest risk of progression. In this study, we investigated the effect of time from transurethral resection of the bladder (TUR-B) to cystectomy on lymph node positivity, cancer-specific survival and overall survival in patients with MIBC. Methods: The records were reviewed of 530 consecutive patients who had RC and pelvic lymphadenectomy procedures with curative intent performed by selected surgeons between May 2005 and April 2016. Our analysis included only patients with transitional cell carcinoma of the bladder; we excluded 23 patients with other types of tumor histology. Results: Patients who underwent delayed RC were compared with patients who were treated with early RC; both groups were similar in terms of age, gender, T stage, tumor grade, tumor differentiation, lymph node status and metastasis status. However, when both groups were compared for disease-free survival and overall survival, patients of the early-RC group had a greater advantage. Conclusions: The optimal time between the last TUR-B and RC is still controversial. A reasonable time for preoperative preparation can be allowed, but long delays, especially those exceeding 3 months, can lead to unfavorable outcomes in cancer control.
Outcomes of Surgery followed by Local Brain Radiotherapy Compared with Surgery followed by Whole Brain Radiotherapy for Single Brain Metastasis
Authors: Igaki Hiroshi , Harada Ken , Umezawa Rei , Miyakita Yasuji , Ohno Makoto , Takahashi Masamichi , Sumi Minako , Inaba Koji , Murakami Naoya , Ito Yoshinori , Narita Yoshitaka , Itami Jun 
Published: June 2017

Purpose To determine the clinical efficacy of surgery followed by local brain radiotherapy (LBRT) for patients with a single brain metastasis, by comparing the results with those of postoperative whole brain radiotherapy (WBRT). Methods We performed a retrospective analysis to compare the survival rate, recurrence-free rates, and causes of death for single brain metastasis patients who underwent surgery followed by LBRT or WBRT in the 2010-2015 period. Results After their surgery, 22 and 32 patients were treated by LBRT and WBRT, respectively. The median survival times for these LBRT and WBRT groups were 18.3 months and 19.2 months, respectively (p = 0.356). The local recurrence-free rates were 81.2% at 1 year and 81.2% at 2 years after LBRT, and 63.8% at 1 year and 58.9% at 2 years after WBRT (p = 0.589). The distant brain recurrence-free rates were 42.5% at 1 year and 25.5% at 2 years after LBRT, and 69.8% at 1 year and 52.4% at 2 years after WBRT (p = 0.044). Distant brain recurrences were observed significantly more frequently in the LBRT group, but the rates of salvage treatment application and survival were not significantly different between the LBRT and WBRT groups. The probability of neurologic death was not significantly higher in the LBRT group compared with the WBRT group. Conclusions Surgery followed by LBRT for single brain metastasis is not inferior to postoperative WBRT, because survival and the necessity of salvage treatment after LBRT were equivalent to those after WBRT.