bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiplatelet therapy after stroke: should it differ in the acute and chronic phase after stroke
Authors: Leng Xinyi , Leung Thomas W. , Wong K.S. Lawrence 
Published: October 2017

Purpose of review
Reviewing existing evidence regarding well tolerated and effective antiplatelet treatment in patients with acute or chronic, noncardioembolic ischemic stroke and transient ischemic attack (TIA).

Recent findings
For patients with high-risk stroke or TIA, for instance, minor stroke or high-risk TIA, or stroke of atherosclerotic origin with evidence suggesting risk of artery-to-artery embolism or with high-grade, symptomatic arterial stenosis, early initiated, short-term dual antiplatelet (e.g. aspirin and clopidogrel) is effective in reducing the risk of recurrent stroke and other vascular events which does not increase the risk of severe or fatal bleeding, as compared with mono antiplatelet therapy. However, long-term application of aggressive antiplatelet therapies after a noncardioembolic stroke or TIA increases the bleeding risks. Triple antiplatelet therapy is not appropriate for noncardioembolic stroke or TIA, in view of the high bleeding risk. In addition, emerging antiplatelets such as ticagrelor and cilostazol may work better in certain subgroups of stroke patients, which warrants further investigation.

Summary
Antiplatelet therapies should differ in the acute and chronic phases among patients with high-risk stroke or TIA when more aggressive antiplatelet treatment is reasonable in the acute phase, but no solid evidence supports different antiplatelet strategies in acute and chronic phases in patients with low-risk noncardioembolic stroke.
New insights into cerebral small vessel disease and vascular cognitive impairment from MRI
Authors: Smith Eric E. , Beaudin Andrew E. 
Published: October 2017

Purpose of review
We review recent MRI research that addresses two important challenges in cerebral small vessel disease (SVD) research: early diagnosis, and linking SVD with cognitive impairment. First, we review studies of MRI measurements of blood flow and blood–brain barrier integrity. Second, we review MRI studies identifying neuroimaging correlates of SVD-related cognitive dysfunction, focusing on brain connectivity and white matter microarchitecture. This research is placed in context through discussion of recent recommendations for management of incidentally discovered SVD, and neuroimaging biomarker use in clinical trials.

Recent findings
Cerebral perfusion, cerebrovascular reactivity (CVR), blood–brain barrier permeability, and white matter microarchitecture are measurable using MRI, and are altered in SVD. Lower cerebral blood flow predicts a higher future risk for dementia, whereas decreased CVR occurs at early stages of SVD and is associated with future white matter hyperintensity growth. Two new approaches to analyzing diffusion tensor imaging (DTI) data in SVD patients have emerged: graph theory-based analysis of networks of DTI connectivity between cortical nodes, and analysis of histograms of mean diffusivity of the hemispheric white matter.

Summary
New, advanced quantitative neuroimaging techniques are not ready for routine radiological practice but are already being employed as monitoring biomarkers in the newest generation of trials for SVD.
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Authors: Bohère Jérôme , Mancheno-Ferris Alexandra , Akino Kohsuke , Yamabe Yuya , Inagaki Sachi , Chanut-Delalande Hélène , Plaza Serge , Kageyama Yuji , Osman Dani , Polesello Cédric , Payre François 
Published: October 2017

AbstractTo compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life yet remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) ofDrosophilaand required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult RNSCs further needs a post-translational processing mediated by Polished rice (Pri) smORF peptides and impairing Svb function leads to RNSC apoptosis. We show that Svb interacts both genetically and physically with Yorkie (YAP/TAZ in vertebrates), a nuclear effector of the Hippo pathway, to activate the expression of the inhibitor of apoptosisDIAP1. These data therefore identify Svb as a novel nuclear effector in the Hippo pathway, critical for the survival of adult somatic stem cells.
Mutualistic acacia-ants show that specialized bacteria are not required for the evolution of herbivory
Authors: Rubin Benjamin E.R. , Kautz Stefanie , Wray Brian D. , Moreau Corrie S. 
Published: October 2017

AbstractAcacia-ant mutualists in the genus Pseudomyrmex nest obligately in acacia plants and, through stable isotope analysis, we show that they are among the strictest of herbivores, feeding exclusively from their hosts. The diets of herbivorous insects such as these are often enriched by obligate bacterial endosymbionts through nitrogen recycling and even gaseous di-nitrogen fixation. We, therefore, examine the bacterial communities associated with mutualistic acacia-ants, comparing them with related non-mutualists in order to determine whether they host bacterial partners likely to contribute to the enrichment of their diets. However, despite their low trophic position, we find no evidence for bacteria-assisted nutrition in either adults or larvae. These acacia-ants do not host any species- or clade-specific bacteria, though several lineages of acetic acid bacteria present across social insects do differ in abundance between mutualists and non-mutualists, likely in response to the sugar-rich diets of their hosts. In addition, two novel lineages of Actinomycetales inhabit both mutualistic and non-mutualistic Pseudomyrmex and differ in abundance between the juveniles of these groups, potentially serving as defensive symbionts. Metagenomic sequencing of these taxa reveal substantial capacity for the production of defensive chemicals. Overall, we find little evidence for nutrition-associated bacteria in these strictly herbivorous ants, showing that bacteria are not as essential to animal nutrition as is often hypothesized.
MAK and CCRK kinases regulate kinesin-2 motility inC. elegansneuronal cilia
Authors: Yi Peishan , Xie Chao , Ou Guangshuo 
Published: October 2017

AbstractKinesin-2 motors power the anterograde intraflagellar transport (IFT), a highly ordered process that assembles and maintains cilia. It remains elusive how kinesin-2 motors are regulatedin vivo. Here we perform forward genetic screen to isolate suppressors that rescue the ciliary defects in the constitutive active mutation of OSM-3-kinesin (G444E) inC. eleganssensory neurons. We identify theC. elegansDYF-5 and DYF-18, which encode the homologs of mammalian male germ cell-associated kinase (MAK) and cell cycle-related kinase (CCRK). Using time-lapse fluorescence microscopy, we show that DYF-5 and DYF-18 are IFT cargo molecules and are enriched at the distal segments of sensory cilia. Mutations ofdyf-5anddyf-18generate the elongated cilia and ectopic localization of kinesin-II at the ciliary distal segments. Genetic analyses reveal thatdyf-5anddyf-18are also important for stabilizing the interaction between IFT particle and OSM-3-kinesin. Our data suggest that DYF-5 and DYF-18 act in the same pathway to promote handover between kinesin-II and OSM-3 in sensory cilia.
Nuclear Abl Drives miR-34c Transfer by Extracellular Vesicles to Induce Radiation Bystander Effects
Authors: Rastogi Shubhra , Hwang Amini , Chan Josolyn , Wang Jean YJ 
Published: October 2017

SUMMARYIonizing radiation stimulates nuclear accumulation of Abl tyrosine kinase that is required for directly irradiated cells to produce microRNA-34c-containing extracellular vesicles, which transfer the microRNA into non-irradiated cells to induce reactive oxygen species and bystander DNA damage.ABSTRACTIonizing radiation (IR) activates an array of DNA damage response (DDR) that includes the induction of bystander effects (BE) in cells not targeted by radiation. How DDR pathways in irradiated cells stimulate BE in non-targeted cells is mostly unknown. We show here that extracellular vesicles from irradiated cells (EV-IR) induce reactive oxygen species (ROS) and DNA damage when internalized by un-irradiated cells. We found that EV-IR from Abl-NLS-mutated cells could not induce ROS or DNA damage, and restoration of nuclear Abl rescued those defects. Expanding a previous finding that Abl stimulates miR-34c expression, we show here that nuclear Abl also drives the vesicular secretion of miR-34c. Ectopic miR-34c expression, without irradiation, generated EV-miR-34c capable of inducing ROS and DNA damage. Furthermore, EV-IR from miR34-knockout cells could not induce ROS and raised γH2AX to lesser extent than EV-IR from miR34-wild type cells. These results establish a novel role for the Abl-miR-34c DDR pathway in stimulating radiation-induced bystander effects.
Morphological phylogenetic analysis with inapplicable data
Authors: Brazeau Martin D. , Guillerme Thomas , Smith Martin R. 
Published: October 2017

AbstractNon-independence of characters is a real phenomenon in phylogenetic data matrices, even though phylogenetic reconstruction algorithms generally assume character independence. In morphological datasets, the problem results in characters that cannot be applied to certain terminal taxa, with this inapplicability treated as “missing data” in a popular method of character coding. However, this treatment is known to create spurious tree length estimates on certain topologies, potentially leading to erroneous results in phylogenetic searches. Here we present a single-character algorithm for ancestral states reconstruction in datasets that have been coded using reductive coding. The algorithm uses up to four traversals on a tree to resolve final ancestral states – which are required in full before a tree can be scored. The algorithm employs explicit criteria for the resolution of ambiguity in applicable/inapplicable dichotomies and the optimization of missing data. We score trees following a previously published procedure that minimizes homoplasy over all characters. Our analysis of published datasets shows that, compared to traditional methods, our new method identifies different trees as “optimal”; as such, correcting for inapplicable data may significantly alter the outcome of tree searches.
Recognition and reward in the academy
Authors: Hammarfelt Björn 
Published: October 2017

Purpose
The publication oeuvre of a researcher carries great value when academic careers are assessed, and being recognised as a successful candidate is usually equated with being a productive author. Yet, how publications are valued in the context of evaluating careers is so far an understudied topic. The paper aims to discuss these issues.

Design/methodology/approach
Through a content analysis of assessment reports in three disciplines – biomedicine, economics and history – this paper analyses how externalities are used to evaluate publication oeuvres. Externalities are defined as features such as reviews and bibliometric indicators, which can be assessed without evaluating the epistemological claims made in the actual text.

Findings
All three fields emphasise similar aspects when assessing: authorship, publication prestige, temporality of research, reputation within the field and boundary keeping. Yet, how these facets of quality are evaluated, and the means through which they are assessed differs between disciplines. Moreover, research fields orient themselves according to different temporal horizons, i.e. history looks to the past and economics to the future when research is evaluated.

Research limitations/implications
The complexities involved in the process of evaluating candidates are also reflected in the findings, and while the comparative approach taken effectively highlights domain specific differences it may also hide counter-narratives, and subtle intradisciplinary discussion on quality.

Originality/value
This study offers a novel perspective on how publications are valued when assessing academic careers. Especially striking is how research across different fields is evaluated through different time horizons. This finding is significant in the debate on more overarching and formal systems of research evaluation.
What makes a nursing home a home? Insights from family members and friends
Authors: Weeks Lori , Chamberlain Stephanie , Keefe Janice 
Published: October 2017

Purpose
The purpose of this paper is to explore the concept of homelikeness from the perspective of family members and friends of nursing home residents across different models of nursing homes.

Design/methodology/approach
This mixed-methods study examined survey data collected from 397 family members and friends of residents living in 23 nursing homes representing three models of care (traditional, new augmented, and full scope). Participants completed a homelikeness scale and a measure of the importance of nursing home spaces to family members and friends. This study also involved conducting three focus groups with 20 family members and friends to provide further insights into the findings.

Findings
Analysis of survey data indicated quite high levels of homelikeness overall. Significant differences did emerge between traditional model nursing homes compared to new full-scope and new augmented models for all items in the homelikeness scale and for many items about nursing home spaces. Qualitative results provided insights into how homelikeness can be fostered through public and private spaces and through care and relationships.

Research limitations/implications
As this study was conducted in one Canadian province, the results may not be applicable to other geographic areas. In addition, there are limitations in survey response rate.

Practical implications
Homelikeness can be supported across models of care by fostering relationships between residents and staff, ensuring that that family and friends feel welcome, and creating public and private physical spaces that are conducive to new and ongoing relationships.

Originality/value
The results provide evidence to nursing home decision makers about how to foster a homelike environment in various models of nursing homes.
Rapid rehousing of formerly homeless jail and prison inmates
Authors: Hignite Lance R. , R. Haff Darlene 
Published: October 2017

Purpose
The purpose of this paper is to assess the programmatic effectiveness of a post-incarceration support service, Jail In-Reach, to rapidly and permanently re-house newly released offenders with a documented history of homelessness, substance abuse and mental health disorders.

Design/methodology/approach
Data were obtained from SEARCH Homeless Services using the Adult Texas Recommended Assessment Guidelines survey instrument by the Texas Department of State Health Services. Repeated measures analysis of variance were performed to determine the effects of select predictors on the likelihood of permanent housing, which, for this research, is considered programmatic success.

Findings
Results indicate clients exhibited decreased risks of self-harm, employment problems, housing instability, co-occurring substance use, and criminal justice involvement as well as increased social support. Over half of the program participants either disappeared from the program or only secured temporary housing.

Research limitations/implications
This was a small pilot project with limited generalizability. There have been no follow-up studies to examine long term permanent housing success. No data were available as to why participants dropped out of the program.

Practical implications
Intensive advocacy and support services provided pre- and post-institutional release could provide formerly homeless inmates with co-occurring substance abuse and mental health issues with positive outcomes.

Social implications
Housing stability and connections to social service agencies are key factors for ensuring ex-offenders do not become re-incarcerated.

Originality/value
This paper contributes to the literature related to reducing homelessness among ex-offenders, to the effectiveness of critical time intervention-based programming, and the need for building social capital amongst this unique and underserved population.
The mediating role of tinnitus perception between hearing impairment and development of psychological problems in male and female tinnitus patients
Authors: Aqeel Muhammad , Ahmed Ammar , Akhtar Tanvir 
Published: October 2017

Purpose
The purpose of this paper is to investigate the mediating role of psychological problems (stress, anxiety, depression) between hearing impairment (HI) and tinnitus in tinnitus patients. Sample comprised of 110 patients (male, n=70; female, n=40).

Design/methodology/approach
The purposive sampling technique was used based on correlational design. Two scales, tinnitus handicap inventory developed by Newman et al. (1996), and depression, anxiety and stress scale developed by Lovibond and Lovibond (1995), were employed to assess tinnitus, anxiety, stress and depression among tinnitus patients.

Findings
The study revealed that tinnitus was positively significant correlated with depression (r=0.55, p<0.001), anxiety (r=0.63, p<0.001), stress (r=0.54, p<0.001) and hearing loss (r=0.81, p<0.001). The results also revealed that hearing loss was positively significant predictor for tinnitus (β=20.72, p<0.001). Further, it was revealed that tinnitus was positively significant predicted by anxiety (β=2.62, p<0.001), stress (β=2.33, p<0.001) and depression (β=2.71, p<0.001); the interaction between psychological symptoms and hearing loss was negatively significant predictor for stress (β=−0.51, p<0.001), anxiety (β=−0.57, p<0.001) and depression (β=−0.62, p<0.001). Moreover, it was revealed that female tinnitus patients were more predisposed to stress, anxiety and depression as compared to male tinnitus patients. Results also elaborated that those tinnitus patient who had profound HI were less inclined toward psychological problems as compared to those tinnitus patients who had mild to moderate level of HI. This study would be helpful for the clinical setting to tackle the psychological problems of tinnitus patients.

Research limitations/implications
This study consisted on population from urban cities of Pakistan; therefore, the findings cannot be generalized on overall population. In future, descriptive as well as experimental studies will be beneficial to describe the mechanism of tinnitus across gender in detail. Native tool for measuring gender-related problems would be effective in future as it integrates cultural aspects as well.

Originality/value
There is a consensus across researchers that tinnitus is one of the most important biological problem which initiates various other psychological problem (Minen et al., 2014; Vogel et al., 2014). Numerous studies have been conducted to find out the relationship of tinnitus with various psychological and biological factors (Boi et al., 2012; Li et al., 2014; Marciano et al., 2003; McCormack et al., 2015; Møller et al., 2010; Udupi et al., 2013; Zöger et al., 2006).
Gender differentials in feeding practices, health care utilization and nutritional status of children in Northern India
Authors: Singh Abhishek , Patel Sangram Kishor 
Published: October 2017

PurposeThe purpose of this paper is to determine the gender differentials in childhood feeding practices, health care utilization and nutritional status of children by birth order and sex composition of previous living children in Northern India.Design/methodology/approachIn this paper, data were drawn from India’s 2006 National Family Health Survey. A variety of different analytic methods were used to look for gender differentials in childhood feeding practices, health care utilization and nutritional status of children. Bi-variate analysis was applied to examine the raw values of gender differentials in childhood feeding, health care and nutritional status of children. Besides, gender differentials at the different birth order and sex composition of previous living children have been measured through multivariate logistic regression analysis.FindingsThe raw values of gender differentials in childhood feeding, health care and nutritional status of children, regardless of child’s birth order, mother’s number of living sons and other characteristics of the child or mother, shows that the proportion of children who received any liquid, proportion of children receiving solid/semi-solid food and the proportion of fully immunized children vary by their gender significantly. The results of standardized gender differentials by birth order and sex composition of previous living children in the selected indicators of childhood feeding, immunization and health care and nutritional status of children based on multivariate binary logistic regression show that among children of birth order 3+ (3 and higher), male children were less likely to receive solid/semi-solid foods during 24 hours prior to the survey in families with no living son, but two times were more likely to receive any solid/semi-solid food than female children in families with 1+ living sons (p<0.0001). Male children aged 12-23 months born to mothers with no living son were more likely to be fully immunized than female children, while male children born to mothers with 1+ living sons were less likely to be fully immunized than female children (p<0.05) at birth order 3+. However, the analysis showed no significant gender differentials in the nutritional status of children.Research limitations/implicationsThe authors observed a strong association between the extents of gender differentials and birth order of the index child and the sex composition of older living siblings. Strong evidence of sex bias against female children was found in families with no living sons and particularly at higher birth orders 2 and 3+ (3 and higher). Overall, the study demonstrates the need to focus on predominance of intra-household differential rather than inter-household differential.Originality/valueThis paper brings out the gender differentials in childhood feeding practices, health care utilization and nutritional status of children by birth order and sex composition of previous living children in Northern India.