bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life, symptoms and treatment satisfaction in patients with aortic aneurysm using new abdominal aortic aneurysm-specific patient-reported outcome measures
Authors: Peach G , Romaine J , Holt P J E , Thompson M M , Bradley C , Hinchliffe R J 
Published: June 2016

AbstractBackgroundThe aim of this study was to present preliminary data on quality of life (QoL), symptoms and treatment satisfaction gathered using three new abdominal aortic aneurysm (AAA)-specific patient-reported outcome measures (PROMs).MethodsPatients with AAA were recruited from five National Health Service Trusts to complete the three new PROMs: the AneurysmDQoL, AneurysmSRQ and AneurysmTSQ. Patients were either under surveillance or had undergone AAA repair (open or endovascular) during the preceding 24 months. Data were initially collected as part of a study assessing the psychometric properties of the new measures, before being used in the observational analysis of outcomes presented here.ResultsResults, although largely non-significant, showed interesting trends. The impact of AAA repair on QoL appeared to worsen progressively after open repair (OR) and improve progressively after endovascular aneurysm repair (EVAR). Conversely, symptoms seemed to become progressively worse after EVAR and progressively better after OR. Information and understanding were key sources of dissatisfaction before the intervention, whereas postoperative dissatisfaction was related to bother from symptoms, follow-up and feedback about scan results.ConclusionAlthough a larger, prospective data set is necessary to explore outcomes more fully with the new AAA-specific PROMs, the observational data presented here suggest there may be clinically important differences in the symptoms, impact on QoL and treatment satisfaction associated with OR and EVAR.
Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin‐Targeting Thiazole Analogue of Bisebromoamide
Authors: Johnston Heather J. , Boys Sarah K. , Makda Ashraff , Carragher Neil O. , Hulme Alison N. 
Published: June 2016

AbstractSystematic alanine scanning of the linear peptide bisebromoamide (BBA), isolated from a marine cyanobacterium, was enabled by solid‐phase peptide synthesis of thiazole analogues. The analogues have comparable cytotoxicity (nanomolar) to that of BBA, and cellular morphology assays indicated that they target the actin cytoskeleton. Pathway inhibition in human colon tumour (HCT116) cells was explored by reverse phase protein array (RPPA) analysis, which showed a dose‐dependent response in IRS‐1 expression. Alanine scanning reveals a structural dependence to the cytotoxicity, actin targeting and pathway inhibition, and allows a new readily synthesised lead to be proposed.
Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues
Authors: Abugrain Mostafa E. , Lu Wanli , Li Yuexin , Serrill Jeffrey D. , Brumsted Corey J. , Osborn Andrew R. , Alani Adam , Ishmael Jane E. , Kelly Jane X. , Mahmud Taifo 
Published: June 2016

AbstractPactamycin is a bacteria‐derived aminocyclitol antibiotic with a wide‐range of biological activity. Its chemical structure and potent biological activities have made it an interesting lead compound for drug discovery and development. Despite its unusual chemical structure, many aspects of its formation in nature remain elusive. Using a combination of genetic inactivation and metabolic analysis, we investigated the tailoring processes of pactamycin biosynthesis in Streptomyces pactum. The results provide insights into the sequence of events during the tailoring steps of pactamycin biosynthesis and explain the unusual production of various pactamycin analogues by S. pactum mutants. We also identified two new pactamycin analogues that have better selectivity indexes than pactamycin against malarial parasites.
Capture‐Tag‐Release: A Strategy for Small Molecule Labeling of Native Enzymes
Authors: Van Dyke Aaron R. , Etemad Lily S. , Vessicchio Michael J. , Naclerio George A. , Jedson Victoria 
Published: June 2016

AbstractA strategy for labeling native enzymes in a manner that preserves their activity is reported: capture–tag–release (CTR). Key to this approach is the small molecule CTR probe that contains an enzyme inhibitor, benzophenone crosslinker, and aryl phosphine ester. After UV‐derived capture of the enzyme, addition of an azide‐containing tag triggers a Staudinger ligation that labels the enzyme. A further consequence of the Staudinger ligation is fragmentation of the CTR probe, thus releasing the inhibitor and restoring enzymatic activity. As a proof‐of‐principle, the CTR strategy was applied to the hydrolase β‐galactosidase. The enzyme was efficiently labeled with biotin, and the kinetic data for the biotinylated enzyme were comparable to those for unlabeled β‐galactosidase. The CTR probe exhibits excellent targeting specificity, as it selectively labeled β‐galactosidase in a complex protein mixture.
Cultivation of Microalgae Using Sewage and Organic Component Evaluation
Authors: Inoue Kenichiro , Uchida Tsutomu 
Published: June 2016

AbstractOutdoor cultivation of microalgae was carried out in 20‐L tanks using sewage influent or effluent, at an actual sewage treatment plant. The microalgae could be cultured by supplying only sewage influent or effluent without additional microalgal stock or nutrient salts. Adding air and CO2 to the culture water promoted not only the cultivation of green algae but also the consumption of nitrogen. Increasing the hydraulic retention time also promoted consumption and cultivation. In particular, adding CO2 to the sewage influent achieved a 59‐fold increase in the cell number of specific Scenedesmus species useful as components for fuel. The microalgae culture progressed even in the autumn/winter. The major organic components eluted by n‐hexane were fatty acids such as palmitic and 11‐hexadecenoic acid. The applicability of sewage culture microalgae as biofuel was demonstrated.
Structured Raney Nickel Catalysts for Liquid‐Phase Hydrogenation
Authors: Wolf Aurel , Turek Thomas , Mleczko Leslaw 
Published: June 2016

AbstractStructured catalysts consisting of metal sheets on which Raney nickel was deposited by the thermal spraying method were tested for the liquid‐phase hydrogenation of glucose to sorbitol and 2‐nitrotoluene to 2‐methylaniline, used as model reactions. Catalytic tests performed in a bench‐scale (1 L) reactor showed that the catalytic activity of Raney Ni sheets is significantly higher than the one of the pellets used for fixed‐bed applications, but lower than the activity of the powder catalyst used in slurry mode. The activity could be significantly improved when applying a two‐phase co‐current flow through a monolith. In this case, the activity was superior to the one obtained with the slurry catalyst. These results confirm the potential of Raney Ni monoliths as structured catalysts.
A Selective RhI‐Catalyzed Substrate‐Controlled C−C Bond Activation of Benzyl Sulfonamide/Alcohol‐Tethered Alkylidenecyclopropanes
Authors: Chen Kai , Liu Jia‐Xin , Tang Xiang‐Ying , Shi Min 
Published: June 2016

AbstractBenzyl sulfonamide/alcohol‐tethered alkylidenecyclopropanes undergo a rhodium‐catalyzed and substrate‐controlled selective C−C bond activation, producing three types of common organic structural units: benzo[c]azepine/oxepines, dihydronaphthalen‐1‐amines, and conjugated dienes. Epoxidation and aromatization of these products to construct two useful compounds have also been achieved.
An Atomically Precise Au10Ag2 Nanocluster with Red–Near‐IR Dual Emission
Authors: Lei Zhen , Guan Zong‐Jie , Pei Xiao‐Li , Yuan Shang‐Fu , Wan Xian‐Kai , Zhang Jin‐Yuan , Wang Quan‐Ming 
Published: June 2016

AbstractA red–near‐IR dual‐emissive nanocluster with the composition [Au10Ag2(2‐py−C≡C)3(dppy)6](BF4)5 (1; 2‐py−C≡C is 2‐pyridylethynyl, dppy=2‐pyridyldiphenylphosphine) has been synthesized. Single‐crystal X‐ray structural analysis reveals that 1 has a trigonal bipyramidal Au10Ag2 core that contains a planar Au4(2‐py−C≡C)3 unit sandwiched by two Au3Ag(dppy)3 motifs. Cluster 1 shows intense red–NIR dual emission in solution. The visible emission originates from metal‐to‐ligand charge transfer (MLCT) from silver atoms to phosphine ligands in the Au3Ag(dppy)3 motifs, and the intense NIR emission is associated with the participation of 2‐pyridylethynyl in the frontier orbitals of the cluster, which is confirmed by a time‐dependent density functional theory (TD‐DFT) calculation.
ChemInform Abstract: Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters.
Authors: Trost Barry M. , Saget Tanguy , Hung Chao‐I 
Published: June 2016

AbstractThe first direct asymmetric Mannich reaction by using α‐branched ketones as nucleophilic partners is presented and gives an enantio‐ and diastereoselective access to various β‐amino ketones.
ChemInform Abstract: Palladium‐Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3Br.
Authors: Beller Matthias , et al.  
Published: June 2016

AbstractThe first palladium‐catalyzed trifluoromethylation of arenes and heteroarenes using CF3Br as trifluoromethyl source is presented.
ChemInform Abstract: Synergistic Gold and Enamine Catalysis: Intermolecular α‐Alkylation of Aldehydes with Allenamides.
Authors: Fernandez‐Casado Jaime , Nelson Ronald , Mascarenas Jose L. , Lopez Fernando 
Published: June 2016

AbstractAldehydes are α‐alkylated with allenamides by the combined action of an organocatalyst and a gold complex.
ChemInform Abstract: A New Solid Acid Catalyst FeCl3/Bentonite for Aldol Condensation under Solvent‐Free Condition.
Authors: Muthuvel I. , Dineshkumar S. , Thirumurthy K. , Rajasri S. , Thirunarayanan G. 
Published: June 2016

AbstractA series of diarylpropenones is synthesized under microwave‐assisted solvent‐free conditions using FeCl3/bentonite as a stable acid catalyst system which can be reused several times without iron leaching.
ChemInform Abstract: Nickel‐Catalyzed Activation of Acyl C—O Bonds of Methyl Esters.
Authors: Hie Liana , Fine Nathel Noah F. , Hong Xin , Yang Yun‐Fang , Houk Kendall N. , Garg Neil K. 
Published: June 2016

AbstractIt is established for the first time that the C—O bonds of simple esters can be activated using a distinct catalytic system.
ChemInform Abstract: Screening, Synthesis, and in vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement‐Dependent Cytotoxicity in Neuromyelitis Optica.
Authors: Kim Sung Min , et al.  
Published: June 2016

AbstractCompound (IIIb) exhibits inhibitory effects against neuromyelitis optica (NMO)‐IgG/CDC and may be a potential therapeutic candidate for NMO treatment.
ChemInform Abstract: Three‐Component Reductive Alkylation of 2‐Hydroxy‐1,4‐naphthoquinones with Lactols.
Authors: Kim Eliana E. , Onyango Evans O. , Pace Jennifer R. , Abbot Timothy M. , Fu Liangfeng , Gribble Gordon W. 
Published: June 2016

AbstractLactols in equilibrium with their open chain hydroxyaldehyde isomers react with naphthoquinone (II) in the presence of Hantzsch ester and catalytic amounts of L‐proline to form the corresponding alkylated products.
ChemInform Abstract: Asymmetric α‐Amination of 3‐Substituted Oxindoles Using Chiral Bifunctional Phosphine Catalysts.
Authors: Jin Qiao‐Wen , Chai Zhuo , Huang You‐Ming , Zou Gang , Zhao Gang 
Published: June 2016

AbstractA variety of chiral 2‐oxindoles is prepared by the title amination of oxindoles with azodicarboxylates in high yields and excellent enantioselectivities.
ChemInform Abstract: Synthesis of Cyclic Carbonates Catalyzed by Chromium and Aluminum Salphen Complexes.
Authors: Castro‐Osma Jose A. , North Michael , Wu Xiao 
Published: June 2016

AbstractNovel aluminium and chromium salphen complexes are prepared (not shown) and applied to the synthesis of cyclic carbonates from a range of epoxides and carbon dioxide.
ChemInform Abstract: Microwave‐Assisted Nickel‐Catalyzed One‐Pot Synthesis of 2,4,5‐Trisubstituted Imidazoles.
Authors: Chundawat Tejpal Singh , Sharma Nutan , Kumari Poonam , Bhagat Sunita 
Published: June 2016

AbstractA N‐(4‐Bromophenyl)salicylidenimine‐derived nickel catalyst is used in the novel microwave‐assisted 3‐component reaction of benzil, arylaldehydes, and ammonium acetate to furnish the title compounds in high yields.
ChemInform Abstract: One‐Pot Four Component Synthesis of Novel 3‐Furyl Coumarin Derivatives.
Authors: Jalli Venkata Prasad , Krishnamurthy Suvratha , Moriguchi Tetsuji , Tsuge Akihiko 
Published: June 2016

AbstractThe four‐component one‐pot reaction of benzopyran (I), secondary amines, dialkyl acetylenedicarboxylates, and isocyanides gives different 3‐furyl coumarin derivatives (V) or (IX) depending on the molar ratio of the reaction partners.
ChemInform Abstract: Fe+3‐Montmorillonite K10 as an Efficient Reusable Heterogeneous Catalyst for the Grind Mediated Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes.
Authors: Fekri Leila Z. , Nikpassand Mohammad , Fard Hajar S. , Marvi Omid 
Published: June 2016

AbstractThe catalyst is inexpensive, non‐toxic, easily to handle, and reusable.
ChemInform Abstract: Synergistic Effect of the TiCl4/p‐TsOH Promoter System on the Aza‐Prins Cyclization.
Authors: Durel Vianney , Lalli Claudia , Roisnel Thierry , van de Weghe Pierre 
Published: June 2016

AbstractIt is shown that the synergism between TiCl4 and p‐TosOH·H2O influences the cyclization reaction of N‐alkyl, N‐aryl, and nonprotected homoallylic amines with various aldehydes.
ChemInform Abstract: Palladium‐Catalyzed Direct C—H Arylation of Pyridine N‐Oxides with Potassium Aryl‐ and Heteroaryltrifluoroborates.
Authors: Li Mengli , Li Xing , Chang Honghong , Gao Wenchao , Wei Wenlong 
Published: June 2016

AbstractA general method for preparation of 2‐arylpyridine N‐oxides from pyridine N‐oxides and (hetero)aryltrifluoroborates is developed.
ChemInform Abstract: C6‐Selective Direct Alkylation of Pyridones with Diazo Compounds under Rh(III)‐Catalyzed Mild Conditions
Authors: Das Debapratim , Biswas Aniruddha , Karmakar Ujjwal , Chand Santanu , Samanta Rajarshi 
Published: June 2016

Abstractusing a pyridyl substituent attached to the nitrogen of the pyridinone ring as directing group
ChemInform Abstract: Synthesis of 4‐Phenyl‐5,6‐dihydrobenzo[h]quinazolines and Their Evaluation as Growth Inhibitors of Carcinoma Cells.
Authors: Maurya Hardesh K. , Hasanain Mohammad , Singh Sarita , Sarkar Jayanta , Dubey Vijaya , Shukla Aparna , Luqman Suaib , Khan Feroz , Gupta Atul 
Published: June 2016

AbstractA cyclization of chalcones with guanidine yields benzo[h]quinazolines which can be easily further converted to compounds (VII) or (IX).
ChemInform Abstract: Gold‐Catalyzed Direct Alkynylation of Tryptophan in Peptides Using TIPS‐EBX.
Authors: Tolnai Gergely L. , Brand Jonathan P. , Waser Jerome 
Published: June 2016

AbstractThe alkynylation of tryptophan in peptides is carried out under mild reaction conditions using the hypervalent iodine reagent (II).
ChemInform Abstract: A Highly Regio‐ and Stereoselective Selenoxide Elimination of 1,2‐Bis[4‐(trimethylsilyl)phenylseleno]alkanes to Give (E)‐Alkenyl Selenoxides and Its Mechanistic Study.
Authors: Tarao Asami , Niki Aya , Komagawa Shinsuke , Arimitsu Kenji , Uchimoto Hitomi , Kawasaki Ikuo , Yamaguchi Kentaro , Nishide Kiyoharu 
Published: June 2016

AbstractOxidation of organo‐selenium compounds (I) with MCPBA generates bisselenoxide intermediates which undergo elimination to give products (II) with high regio‐ and E/Z‐selectivity.
Katalysatoren des Leuna Werkes 1945 – 1988: Von der Empirie zur Wissenschaft. Teil III: Hydroraffinationskatalysatoren
Authors: Becker Karl 
Published: June 2016

AbstractIn Teil 1 dieser Berichtsreihe wurde der Weg der Entwicklung und Fertigung technischer Katalysatoren im Leuna Werk in den Jahren 1921 – 1945, in Teil 2 die Entwicklung von Reformier‐ und Isomerisierungskatalysatoren in den Jahren von 1950 – 1991 dargestellt. Der vorliegenden dritte Teil verfolgt den Weg der für die Wirtschaft der DDR wichtigen Gruppe der Hydroraffinationskatalysatoren. 36 Katalysatoren und 15 spezielle Aluminiumoxide sowie röntgenamorphe und kristalline Alumosilikate wurden für die Leunaer Hydrierung und weitere Raffineriebetriebe der DDR einwickelt und zum technischen Einsatz gebracht. Neue Verfahren wurden erarbeitet und mit maßgeschneiderten Katalysatoren ausgestattet.
Selective Introduction of Carbazole and Diphenylamine into Spirofluorenexanthene Core for Different Phosphorescent Hosts
Authors: Sun Mingli , Yue Shouzhen , Cao Hongtao , Ou Changjin , Qian Yan , Wang Ting , Chen Ligang , Zhao Yi , Huang Wei 
Published: June 2016

AbstractBuilt on the spiro[fluorene‐9,9′‐xanthene] (SFX) core and two frequently‐used hole‐transporting groups such as carbazole and diphenylamine, two SFX derivatives, namely SFXCz and SFXDPA, have been synthesized by one‐step reaction for red, green and blue phosphorescent organic light‐emitting devices (PHOLEDs). Though the properties of these two groups are very similar, the devices based on SFXCz and SFXDPA exhibit distinct performances. In blue PHOLEDs, the device based on SFXCz exhibited much better performances than that based on SFXDPA. However, the latter was superior to the former in green and red PHOLEDs. And the red PHOLED based on SFXDPA exhibited maximum current efficiency (CE) of 27.1 cd·A−1, power efficiency (PE) of 25.0 lm·W−1, and external quantum efficiency (EQE) of 15.0%. The results show that the introduction of diphenylamine group is suitable for constructing green and red host materials, whereas the introduction of carbazole group is suitable for constructing blue host materials.
Accommodation of Symptoms in Anorexia Nervosa: A Qualitative Study
Authors: Fox John R. E. , Whittlesea Anna 
Published: June 2016

Anorexia nervosa (AN) continues to remain poorly understood within eating disorders. Recent research and theory have moved away from understanding its aetiological causes, addressing instead potential maintaining factors. This study is focused on interpersonal maintenance factors: the response of close others. Relatives of those with AN typically carry the main burden of care, and research has found high levels of carer distress and unmet needs. Recent theories have proposed this emotional impact to contribute to expressed emotion and other unhelpful caregiver interactions which inadvertently maintain AN. One such understudied response is accommodation, described as a ‘process’ whereby caregivers ‘assist or participate’ in symptomatic behaviours of the cared for individual. There is a dearth of research relating to accommodation within eating disorders, particularly qualitative accounts. This study utilized a grounded theory methodology to explore caregivers' responses to managing AN, focusing particularly on carers' experience of accommodation. Eight participants with experience of caring for an individual diagnosed with AN were interviewed. Participants were recruited from a national eating disorder charity and regional eating disorder service. A number of themes emerged, including the importance of caregivers' emotional resources in mediating accommodation responses. Low‐perceived efficacy over AN contributed to caregiver burnout. Decreased emotional resources influenced a shift in caregiving aims conducive with accommodation. Nevertheless, carers perceived accommodation as counterproductive to recovery and consequently experienced internal conflict (cognitive dissonance). Dissonance was reduced using a number of cognitive and behavioural strategies. The implications of these findings are discussed with reference to existing literature. Copyright © 2016 John Wiley & Sons, Ltd.Key Practitioner Message

Anorexia nervosa (AN) can be difficult to manage. Over time, carers can feel powerless, and their emotional resources diminish.
Diminished resources led to a shift in caregiving aims and responses. Subsequently, carers accommodated AN‐related behaviours.
Carers recognized accommodation as counterproductive and experienced internal conflict (dissonance). This was reduced using a number of strategies.
Skill‐based interventions designed to empower carers to manage difficult AN behaviours are recommended.
Motivational interviewing to develop discrepancies between caregiving aims and responses may promote a shift in the caregiving approach.
Multilateral Institutions and Conflict Resolution
Authors: Grigorescu Alexandru , Melin Molly M. 
Published: June 2016

AbstractStates have a multitude of tools for territorial dispute resolution at their disposal ranging from direct bilateral negotiations to third‐party states to international organizations (IOs). While the literature explores when states are more likely to accept a third party in their negotiations and when they are more likely to seek a resolution to their disputes bilaterally, we have little understanding of why states are more likely to seek IOs for such tasks. We examine the disputants that prefer certain conflict managers, with a focus on the distinguishing characteristics of IO‐led conflict management. We derive a set of hypotheses based on our expectations that, due to the institutional and multilateral characteristics of IOs, certain states will turn to them to resolve their disputes while others will avoid them. Using the Issue Correlates of War data, we find support for our hypotheses. We conclude that the institutional and multilateral characteristics of negotiations indeed affect states’ conflict resolution choices.
Understanding the Interactions of CO2 with Doped and Undoped SrTiO3
Authors: Wu Qiyuan , Cen Jiajie , Goodman Kenneth R , White Michael G. , Ramakrishnan Girish , Orlov Alexander 
Published: June 2016

AbstractSrTiO3 and doped SrTiO3 have a wide range of applications in different fields. For example, Rh‐doped SrTiO3 has been shown to have photocatalytic activity for both hydrogen production and CO2 conversion. In this study, both undoped and Rh‐doped SrTiO3 were synthesized by hydrothermal and polymerizable complex methods. Different characterizations techniques including X‐ray photoelectron spectroscopy (XPS), XRD, Raman, and UV/Vis spectroscopy were utilized to establish correlations between the preparation methods and the electronic/structural properties of Rh‐doped SrTiO3. The presence of dopants and oxygen vacancies substantially influenced the CO2 interactions with the surface, as revealed by the in situ infrared spectroscopic study. The presence of distinctly different adsorption sites was correlated to oxygen vacancies and oxidation states of Ti and Rh.
Nanocarbon‐based Electrochemical Detection of Heavy Metals
Authors: Pandey Shailendra Kumar , Singh Priti , Singh Jyoti , Sachan Sadhana , Srivastava Sameer , Singh Sunil Kumar 
Published: June 2016

AbstractHeavy metal species are toxic, non‐decomposable molecules which exist in our ecological systems and food chains, eventually exposing us to serious health hazards and economic damage. In this context, various attempts have been made for sensitive detection of heavy metal ions through electrochemical sensor. Carbon nanomaterials endowed with unique physiochemical properties were found to be most suitable for electrochemical detection of heavy metal due to their ease to modify, high sensitivity, good selectivity and high reproducibility. Here, we present a critical review about detection of heavy metals using nanocarbon with focus on graphene and carbon nanotubes in various sources of water, soil, and foods for fast and sensitive detection of heavy metal ions. We have evaluated the current trends and discussed the major challenges associated with electrode modification and electrochemical analysis with the aim to achieve the best sensing performance.