bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia
Authors: O’Connor David , Moorman Anthony V. , Wade Rachel , Hancock Jeremy , Tan Ronald M.R. , Bartram Jack , Moppett John , Schwab Claire , Patrick Katharine , Harrison Christine J. , Hough Rachael , Goulden Nick , Vora Ajay , Samarasinghe Sujith 
Published: February 2017

Purpose Our aim was to determine the role of end-of-induction (EOI) minimal residual disease (MRD) assessment in the identification and stratification of induction failure in patients with pediatric acute lymphoblastic leukemia (ALL) and to identify genetic abnormalities that drive disease in these patients. Patients and Methods Analysis included 3,113 patients who were treated in the Medical Research Council UKALL2003 multicenter randomized trial (NCT00222612) between 2003 and 2011. MRD was measured by using standardized real-time quantitative PCR. Median follow-up was 5 years 9 months. Results Fifty-nine patients (1.9%) had morphologic induction failure with 5-year event-free survival (EFS) of 50.7% (95% CI, 37.4 to 64.0) and 5-year overall survival of 57.7% (95% CI, 44.2 to 71.2). Of these, a small proportion of patients with M2 marrow (6 of 44) and a low EOI MRD level (< 0.01%) had 5-year EFS of 100%. Conversely, among patients with morphologic remission 2.3% (61 of 2,633) had high MRD (≥ 5%) and 5-year EFS of 47.0% (95% CI, 32.9 to 61.1), which was similar to those with morphologic induction failure. Redefining induction failure to include morphologic induction failure and/or MRD ≥ 5% identified 3.9% (120 of 3,133 patients) of the trial cohort with 5-year EFS of 48.0% (95% CI, 39.3 to 58.6). Induction failure (morphologic or MRD ≥ 5%) occurred most frequently in T-ALL (10.1%; 39 of 386 T-ALL cases) and B-other ALL, that is, lacking established chromosomal abnormalities (5.6%; 43 of 772 B-other cases). Genetic testing within the B-other group revealed the presence of PDGFRB gene fusions, particularly EBF1-PDGFRB, in almost one third of B-other ALL cases. Conclusion Integration of EOI MRD level with morphology identifies induction failure more precisely than morphology alone. Prevalence of EBF1-PDGFRB fusions in this group highlights the importance of genetic screening to identify abnormalities that may be targets for novel agents.
Management of Small Renal Masses: American Society of Clinical Oncology Clinical Practice Guideline
Authors: Finelli Antonio , Ismaila Nofisat , Bro Bill , Durack Jeremy , Eggener Scott , Evans Andrew , Gill Inderbir , Graham David , Huang William , Jewett Michael A.S. , Latcha Sheron , Lowrance William , Rosner Mitchell , Shayegan Bobby , Thompson R. Houston , Uzzo Robert , Russo Paul 
Published: February 2017

PurposeTo provide recommendations for the management options for patients with small renal masses (SRMs).MethodsBy using a literature search and prospectively defined study selection, we sought systematic reviews, meta-analyses, randomized clinical trials, prospective comparative observational studies, and retrospective studies published from 2000 through 2015. Outcomes included recurrence-free survival, disease-specific survival, and overall survival.ResultsEighty-three studies, including 20 systematic reviews and 63 primary studies, met the eligibility criteria and form the evidentiary basis for the guideline recommendations.RecommendationsOn the basis of tumor-specific findings and competing risks of mortality, all patients with an SRM should be considered for a biopsy when the results may alter management. Active surveillance should be an initial management option for patients who have significant comorbidities and limited life expectancy. Partial nephrectomy (PN) for SRMs is the standard treatment that should be offered to all patients for whom an intervention is indicated and who possess a tumor that is amenable to this approach. Percutaneous thermal ablation should be considered an option if complete ablation can reliably be achieved. Radical nephrectomy for SRMs should only be reserved for patients who possess a tumor of significant complexity that is not amenable to PN or for whom PN may result in unacceptable morbidity even when performed at centers with expertise. Referral to a nephrologist should be considered if chronic kidney disease (estimated glomerular filtration rate < 45 mL/min/1.73 m2) or progressive chronic kidney disease occurs after treatment, especially if associated with proteinuria.
Contrasting effects of increased yolk testosterone content on development and oxidative status in gull embryos
Authors: Parolini Marco , Romano Andrea , Possenti Cristina Daniela , Caprioli Manuela , Rubolini Diego , Saino Nicola 
Published: February 2017

ABSTRACTHormone-mediated maternal effects generate variation in offspring phenotype. In birds, maternal egg testosterone (T) exerts differential effects on offspring traits after hatching, suggesting that mothers experience a trade-off between contrasting T effects. However, there is very little information on T pre-natal effects. In the yellow-legged gull (Larus michahellis), we increased yolk T concentration within physiological limits and measured the effects on development and oxidative status of late-stage embryos. T-treated embryos had a larger body size but a smaller brain than controls. Males had a larger brain than females, controlling for overall size. T treatment differentially affected brain mass and total amount of pro-oxidants in the brain depending on laying order. T-treatment effects were not sex dependent. For the first time in the wild, we show contrasting T pre-natal effects on body mass and brain size. Hence, T may enforce trade-offs between different embryonic traits, but also within the same trait during different developmental periods.
Den Alltag beleuchten. Beobachtungen zu Andachten in der Deutschschweiz
Authors: Köhler-Andereggen Andreas 
Published: February 2017

Zusammenfassung
Der Beitrag nimmt Andachten und Alltagsminiaturen in den Blick, die im Radio und Fernsehen in der Deutschschweiz gesendet wurden, zum Angebot der Zürcher Bahnhofkirche gehörten oder auf der Homepage der Reformierten Zürcher Landeskirche aufgeschaltet sind. Die hier verwendeten Gattungen werden beschrieben und theologisch analysiert.
Priestertum aller Glaubenden? Digitale Formen von Andacht und Partizipationsmöglichkeiten
Authors: Luthe Swantje 
Published: February 2017

Zusammenfassung
Mit der Mediatisierung der Kommunikationszusammenhänge ins Digitale ergeben sich neue Räume, neue (Teil-)Öffentlichkeiten mitten im Alltag, in denen religiöse Rede generiert wird. Dieser Beitrag will der Frage nachgehen, inwiefern die Ausdrucksformen in sozialen Netzwerken sich als Formen von Andacht verstehen lassen. Nach einer Annäherung an den Begriff Andacht und einem explorativen Blick auf digitale Formate wird der Versuch einer theoretischen Einordnung unternommen.
Inactivation of GIRK channels weakens the pre‐ and postsynaptic inhibitory activity in dorsal raphe neurons
Authors: Llamosas Nerea , Ugedo Luisa , Torrecilla Maria 
Published: February 2017

AbstractThe serotonergic tone of the dorsal raphe (DR) is regulated by 5‐HT1A receptors, which negatively control serotonergic activity via the activation of G protein‐coupled inwardly rectifying K+ (GIRK) channels. In addition, DR activity is modulated by local GABAergic transmission, which is believed to play a key role in the development of mood‐related disorders. Here, we sought to characterize the role of GIRK2 subunit‐containing channels on the basal electrophysiological properties of DR neurons and to investigate whether the presynaptic and postsynaptic activities of 5‐HT1A, GABAB, and GABAA receptors are affected by Girk2 gene deletion. Whole‐cell patch‐clamp recordings in brain slices from GIRK2 knockout mice revealed that the GIRK2 subunit contributes to maintenance of the resting membrane potential and to the membrane input resistance of DR neurons. 5‐HT1A and GABAB receptor‐mediated postsynaptic currents were almost absent in the mutant mice. Spontaneous and evoked GABAA receptor‐mediated transmissions were markedly reduced in GIRK2 KO mice, as the frequency and amplitude of spontaneous IPSCs were reduced, the paired‐pulse ratio was increased and GABA‐induced whole‐cell currents were decreased. Similarly, the pharmacological blockade of GIRK channels with tertiapin‐Q prevented the 5‐HT1A and GABAB receptor‐mediated postsynaptic currents and increased the paired‐pulse ratio. Finally, deletion of the Girk2 gene also limited the presynaptic inhibition of GABA release exerted by 5‐HT1A and GABAB receptors. These results indicate that the properties and inhibitory activity of DR neurons are highly regulated by GIRK2 subunit‐containing channels, introducing GIRK channels as potential candidates for studying the pathophysiology and treatment of affective disorders.
Rare birds in Slovenia in 2015 – Slovenian Rarities Committee’s Report
Authors: Hanžel Jurij 
Published: February 2017

Summary
This report by the Slovenian Rarities Committee presents records of rare bird species in Slovenia in 2015, with some addenda for previous years. The numbers in brackets refer to the number of records (first number) and individuals (second number) recorded between 1 Jan 1950 and 31 Dec 2014. Since 1 Jan 2013, submission to the Committee has been required for 37 additional species, 17 of which are regional rarities. Records of these species are not numbered, since records from previous years were not collected by the Committee. One new species, the Desert Wheatear Oenanthe deserti, was added to category A. Other notable observations were the first record of Parrot Crossbill Loxia pytyopsittacus after 1909, the second record of Baillon’s Crake Zapornia pusilla, the third and fourth records of Calandra Lark Melanocorypha calandra, the fourth of Long-legged Buzzard Buteo rufinus, the fifth of Richard’s Pipit Anthus richardi and the sixth of Grey Phalarope Phalaropus fulicarius. Four species were added to category E: Bahama Pintail Anas bahamensis, Rosy-billed Pochard Netta peposaca, Harris’s Hawk Parabuteo unicinctus and Alexandrine Parakeet Psittacula eupatria. The list of birds recorded in Slovenia (as of 31 Dec 2015) contains 386 species (371 in category A, 6 in category B, 9 exclusively in category C; 4 species are both in categories A and C). Category D contains 6 species, while category E contains 38, two of which are classified into subcategory E*. These two categories are not part of the list.
The effects of integrating goal setting and reading strategy instruction on English reading proficiency and learning motivation: A quasi-experimental study
Authors: Shih Ying-Chun , Reynolds Barry Lee 
Published: February 2017

AbstractAn English as a Foreign Language (EFL) reading class was transformed by integrating goal setting with reading strategy instruction for one academic year. This intervention class was compared to a traditionally taught class to determine whether any differences in terms of motivation towards learning English and reading proficiency would be found. The goals set by the intervention class were analyzed to determine (1) whether they were met and (2) what actions were performed to reach those goals. In addition, it was further investigated whether adolescent Taiwanese students are willing to be taught English reading using an approach incorporating goal setting and reading strategy instruction. Results indicate that goal setting integrated reading strategy instruction seems to be more effective in increasing reading proficiency and learner motivation than the traditional approach as well as encouraging learner autonomy and self-efficacy. Analysis of the actions performed by the intervention group to meet goals revealed two sub-groups of learners: static action students and dynamic action students. Data analysis further indicated the actions performed by dynamic action students consisted of more diverse and concrete learning strategies whereas static action students performed mostly classroom-centered review. Pedagogical implications of the results and future research directions are discussed.
Results on (UN)Published Wet Runs on Pulsating DB White Dwarfs
Authors: Handler G. 
Published: February 2017

AbstractI have collected all the WET archival data on the pulsating DB white dwarf stars (DBVs) and re-reduced them. In addition, the WET has recently observed three DBVs. Preliminary results on PG 1115+158, PG 1351+489, KUV 05134+2605, PG 1654+160 and PG 1456+103 are presented, and the future use of the data is outlined.
PG 1605+072 in Wet XCov22: Support for the Multi Site Spectroscopic Telescope
Authors: Schuh S. L. , Heber U. , Dreizler S. , O’Toole S. , Jeffery C. S. , Falter S. , Woolf V.M. , Riddle R. L. , Handler G. , Hürkal Ö. , Pakštiene E. , Klumpe E.W. , Laurance T. , Vuckovic M. , Zoła S. , Kawaler S. D. , Kanaan A. , Monteiro H. , Giovannini O. , Kepler S. O. , Mukadam A. , Provencal J.L. , Nitta A. , Shipman H. , Mullally F. , Grauer A. , Wood M.A. , Bradley P.A. , Kilic M. , Sekiguchi K. , Crowe R. , Sullivan D. J. , Rosen R. , Clemens C. , Xiaojun J. , Janulis R. , O’Donoghue D. , Ogloza W. , Baran A. , Silvotti R. , Marinoni S. , Vauclair G. , Dolez N. , Chevreton M. , Deetjen J. L. , Nagel T. , Pérez J.M. González , Solheim J.-E. , Østensen R. , Ulla A. , Burleigh M. , Good S. , Metcalfe T. S. , Costa A. F.M. da , Costa J. E. S. , O’Brien M.S. , Kim S.-L. , Lee H. , Sergeev A. , Akan C. , Cakirli Ö. , Paparo M. , Viraghalmy G. 
Published: February 2017

AbstractThe Multi-site spectroscopic telescope is a virtual instrument and the name of a collaboration that opens up a new observational window by combining continuous observations of spectroscopic variations and simultaneous photometric monitoring. This constitutes an enormous observational effort, but in return promises to finally provide access to a mode identification for and an asteroseismological analysis of the pulsating sdB star PG 1605+072. Multi-Site Spectroscopic Telescope observations for this object have been secured during a large coordinated campaign in May and June of the year 2002. The frequency resolution and coverage of the photometric time series has been noticeably enhanced by a significant contribution from the Whole Earth Telescope, which was used to observe PG 1605+072 as an alternate target during the WET XCov22 campaign, also conducted in May 2002. This paper briefly outlines the motivation for the MSST project and tries to give a first assessment of the overall quality of the data obtained, with a focus on the Whole Earth Telescope observations.
Constraining the Evolution of ZZ Ceti
Authors: Mukadam A. S. , Kepler S. O. , Winget D. E. , Nather R. E. , Kilic M. , Mullally F. , Hippel T. von , Kleinman S. J. , Nitta A. , Guzik J. A. , Bradley P. A. , Matthews J. , Sekiguchi K. , Sullivan D. J. , Shobbrook R. R. , Birch P. , Jiang X. J. , Xu D. W. , Joshi S. , Ashoka B.N. , Ibbetson P. , Leibowitz E. , Ofek E. O. , Meištas E. G. , Janulis R. , Ališauskas D. , Kalytis R. , Handler G. , Kilkenny D. , O’Donoghue D. , Kurtz D. W. , Müller M. , Moskalik P. , Ogłoza W. , Zoła S. , Krzesiński J. , Johannessen F. , Gonzalez-Perez J. M. , Solheim J-E. , Silvotti R. , Bernabei S. , Vauclair G. , Dolez N. , Fu J. N. , Chevreton M. , Manteiga M. , Súarez O. , Ulla A. , Cunha M. S. , Metcalfe T. S. , Kanaan A. , Fraga L. , Costa A. F. M. , Giovannini O. , Fontaine G. , Bergeron P. , O’Brien M. S. , Sanwal D. , Wood M. A. , Ahrens T. J. , Silvestri N. , Klumpe E. W. , Kawaler S. D. , Riddle R. , Reed M. D. , Watson T. K. 
Published: February 2017

AbstractWe report our analysis of the stability of pulsation periods in the DAV star (pulsating hydrogen atmosphere white dwarf) ZZ Ceti, also called R548. Based on observations that span 31 years, we conclude that the period 213.132605 s observed in ZZ Ceti drifts at a rate dP/dt≤(5.5±1.9)×10Constraining the cooling rate of ZZ Ceti aids theoretical evolutionary models and white dwarf cosmochronology. The drift rate of this clock is small enough that reflex motion caused by any orbital planets is detectable within limits; our Ṗ constraint places limits on the mass and/or distance of any orbital companions.
High Precision with the Whole Earth Telescope: Lessons and Some Results from XCov20 for the roAp Star HR 1217
Authors: Kurtz D. W. , Kawaler S.D. , Riddle R. L. , Reed M.D. , Cunha M. S. , Wood M. , Silvestri N. , Watson T.K. , Dolez N. , Moskalik P. , Zola S. , Pallier E. , Guzik J.A. , Metcalfe T. S. , Mukadam A. , Nather R.E. , Winget D.E. , Sullivan D. J. , Sullivan T. , Sekiguchi K. , Jiang X.J. , Shobbrook R.R. , Birch P.V. , Ashoka B. N. , Seetha S. , Joshi S. , Girish V. , O’Donoghue D. , Handler G. , Mueller M. , Perez J.M. Gonzalez , Solheim J.-E. , Johannessen F. , Ulla A. , Kepler S.O. , Kanaan A. , Costa A.da , Fraga L. , Giovannini O. , Matthews J. M. , Cameron C. , Vauclair G. , Nitta A. , Kleinman S. J. 
Published: February 2017

AbstractHR1217 is a prototypical rapidly oscillating Ap star that has presented a test to the theory of nonradial stellar pulsation. Prior observations showed a clear pattern of five modes with alternating frequency spacings of 33.3 μHz and 34.6 μHz, with a sixth mode at a problematic spacing of 50.0 μHz (which equals 1.5 × 33.3 μHz) to the highfrequency side. Asymptotic pulsation theory allowed for a frequency spacing of 34 μHz, but hipparcos observations rule out such a spacing. Theoretical calculations of magnetoacoustic modes in Ap stars by Cunha (2001) predicted that there should be a previously undetected mode 34 μHz higher than the main group, with a smaller spacing between it and the highest one. The 20th extended coverage campaign of the Whole Earth Telescope (XCov20) has discovered this frequency as predicted by Cunha (2001). Amplitude modulation of several of the pulsation modes between the 1986 and 2000 data sets has also been discovered, while important parameters for modelling the geometry of the pulsation modes have been shown to be unchanged. With stringent selection of the best data from the WET network the amplitude spectrum shows highest peaks at only 50 μmag and formal errors on the determined amplitudes are 14 μmag. Some lessons for future use of WET for the highest precision photometry on bright stars are discussed.
Mauna Kea High Speed Photometry of Transits of the Extrasolar Planet HD 209458B
Authors: Sullivan Denis J. , Sullivan Tiri 
Published: February 2017

AbstractUsing high-speed photometry techniques, three transits of the extrasolar planet across the disk of the star HD 209458 have been observed. The combination of a WET-style 3-channel photometer and an excellent site yielded millimagnitude photometric precision. The various techniques used to reduce the raw data obtained under different observing conditions are presented along with modelling of the transit light curves. Finally, a summary of what we have learned about this unique extrasolar planet is provided.
Mt. Dushak-Erekdag Observatory: A Chance to Close the Asian Gaps in WET Coverage
Authors: Dorokhova T. N. , Dorokhov N. I. 
Published: February 2017

AbstractThe Mt. Dushak-Erekdag Observatory (Central Asia, Turkmenistan, 58° E longitude) is located just in the longitudes gap of asteroseismological networks. It is the southernmost observatory of the former Soviet Union, its latitude is +38°. The sky seeing at the site is one of the best in Central Asia: a low light pollution, high and stable sky transparency, over 200 usable nights per year. The altitude is above 2000 m.Odessa Astronomical Observatory has its 0.8 m telescope with a two-star high-speed photometer there, which frequently participates in international programs and multi-site campaigns. An accuracy of the photometry amounts to 1 mmag. Besides, a 1 m wide-angle telescope and a dual-tube telescope with 0.5m mirrors are installed at the observatory.The developed infrastructure at the site and the stable economy in Turkmenistan make the Mt. Dushak-Erekdag Observatory very interesting for the WET observations.
The Depth of the Heavens – Belief and Knowledge During 2500 Years
Authors: Høg Erik 
Published: February 2017

Abstract
For Dante Alighieri (1265-1321) the spiritual cosmos contained the Heavens, Earth and Hell, and it was compatible with the physical cosmos known from Aristotle (384-322 B.C.). Dante’s many references in his Divine Comedy to physical and astronomical subjects show that he wanted to treat these issues absolutely correctly. Tycho Brahe proves three hundred years later by his observations of the Stella Nova in 1572 and of comets that the spheres of heavens did not really exist. It has ever since become more and more difficult to reconcile the ancient ideas of a unified cosmos with the increasing knowledge about the physical universe. Ptolemaios derived a radius of 20 000 Earth radii for the sphere of fixed stars. This radius of the visible cosmos at that time happens to be nearly equal to the true distance of the Sun, or 14 micro-light-years. Today the radius of the visible universe is a million billion (1015) times larger than Tycho Brahe believed. The lecture gave an overview of astronomical distances and their dramatic change during two and a half millennia, the following text is an extract hereof.
The Reduction of CCD Images for Stellar Photometry on the Vatt
Authors: Janusz R. , Boyle R. P. , Philip A. G. Davis 
Published: February 2017

Abstract
We briefly describe a method of organizing all the star field exposures taken in a complete CCD observational run. By a “CommandLog” (to be published in J. Astron. Data) one can organize all the observations and process them within IRAF in an orderly, automated manner to arrive at stellar photometry calibrated into a standard photometric system (in our case, Strömvil). During the course of this processing we determine the error of the flat and try to correct it.
Calibration of the Strömvil Photometric System
Authors: Kazlauskas A. , Straižys V. , Boyle R. P. , Philip A. G. Davis , Laugalys V. , Černis K. , Sperauskas J. 
Published: February 2017

Abstract
A calibration of color indices of the Strömvil photometric system in terms of physical parameters of stars is presented. The calibration is based on photoelectric photometry of about 1000 stars with known effective temperatures, distances, gravities and metallicities. The observations were accomplished in 2000-2003 with the 1.5 meter telescope of the Steward Observatory. The distances were taken from the Hipparcos catalog, and Te, log g, [Fe/H]) were collected from several literature sources and averaged.
Large-Scale Errors In CCD Photometry of M67
Authors: Laugalys V. , Boyle R. P. , Kazlauskas A. , Vrba F. J. , Philip A. G. Davis , Straižys V. 
Published: February 2017

Abstract
The accuracy of new CCD photometry in the Vilnius system of the M67 cluster is analyzed. The observational material is obtained during six observing runs in 1994-2001 with the 1 meter telescope of the USNO Flagstaff Station. The main task was to establish CCD standards of high accuracy and to eliminate large-scale errors from our CCD photometry. We compare our results with the published CCD photometric data in other photometric systems. The comparison reveals considerable systematic errors in some datasets.
Variations of the Ratio of Total-To-selective Extinction in the Galaxy
Authors: Sūdžius J. , Raudeliūnas S. 
Published: February 2017

Abstract
The results of the study of variations of total-to-selective extinction RV near the Galactic plane (-12° ≤ b ≤+12°) are presented. It is shown that variations of RV range from 1.9 to 3.4 and it is not possible to determine its typical value for the Galaxy. The conclusion that variations of the parameter RV closely correlates with the distribution of interstellar extinction is confirmed.