bluuebunny/crossref_metadata_2025_split huggingface dataset:
Test Dose Pharmacokinetics in Pediatric Patients Receiving Once‐Daily IV Busulfan Conditioning for Hematopoietic Stem Cell Transplant: A Reliable Approach?
Authors: Brooks Kristina M. , Jarosinski Paul , Hughes Thomas , Kang Elizabeth , Shah Nirali N. , Gall John B. Le , Hickstein Dennis D. , De Ravin Suk See , George Jomy M. , Kumar Parag 
Published: December 2017

AbstractIntravenous (IV) busulfan test dose pharmacokinetics (PK) has been shown to accurately predict once‐daily dose requirements and improve outcomes in adult transplant patients, but there are limited data to support this approach in children. Test doses of busulfan ∼0.8 mg/kg were infused over 2 to 3 hours, followed by serial sampling to 4‐6 hours postinfusion in pediatric hematopoietic stem cell transplant recipients (n = 5). Once‐daily busulfan doses were calculated based on a myelosuppressive area under the concentration‐time curve (AUC) target of ∼3700 to 4000 μmol·min/L and assumed dose‐proportionality to the test dose. PK analysis was then repeated at full daily doses within 6‐8 days of test dose administration. Plasma PK samples collected under test and full‐dose conditions were analyzed using validated commercial assays and noncompartmental methods. In 4 out of 5 patients, PK estimates after once‐daily IV busulfan administration differed in comparison to test dose estimates (AUC range –38.2% to +49.7%, clearance range –34.3% to +61.8%). Patients 1, 2, and 3 required increases in remaining daily busulfan doses to achieve AUC targets, and no adjustment was required in patient 4. Patient 5's AUC was 49.7% higher than expected, and he subsequently developed fatal sinusoidal obstruction syndrome. In our experience with pediatric patients, test dose PK failed to reliably predict daily dosing requirements with large discrepancies from predicted AUC targets. This article highlights the necessity for therapeutic drug monitoring of IV busulfan and inadvisability of relying solely on test‐dose busulfan PK in pediatric patients. Furthermore, clinicians should consider strategies to expedite dose adjustments in real time.
Cross‐country Evidence of the Relationship Between Resilience and the Subjective Perception of Well‐being and Social Inclusion: Evidence from the Regions of Matam (Senegal) and the Triangle of Hope (Mauritania)
Authors: d'Errico Marco , Grazioli Francesca , Pietrelli Rebecca 
Published: December 2017

AbstractResilience, commonly perceived as an unobservable household characteristic, has been defined differently according to each measurement approach utilized. This paper contributes to the literature, both conceptually, by reviewing the link between resilience, subjective well‐being and social inclusion; and analytically, by providing statistical evidence of whether subjective measures of well‐being are associated with higher household resilience. The paper shows that those who perceive themselves and their community to be involved in the decision‐making process related to policies and service provision are associated with greater resilience capacity. The empirical evidence is based on two household surveys in Senegal and Mauritania. Copyright © 2017 John Wiley & Sons, Ltd.
Employee reactions to talent management: Assumptions versus evidence
Authors: De Boeck Giverny , Meyers Maria Christina , Dries Nicky 
Published: December 2017

SummaryTwo assumptions about employee reactions are currently driving debates around talent management (TM): First, that TM leads to positive outcomes in employees identified as talents; and second, that TM creates differences between talents and employees not identified as talents. This review critically evaluates these assumptions by contrasting theoretical arguments from the non‐empirical literature on employee reactions to TM with the empirical evidence available. Our analysis partly supports both assumptions. Although positive reactions to TM were indeed found in terms of affective, cognitive, and behavioral employee outcomes, our review also found evidence for negative affective reactions in employees identified as talents. Significant differences between talents and non‐talents were found for behavioral reactions, but not for affective and cognitive reactions; for the latter types of reactions, our review found mixed effects. We summarize these findings in an integrative framework on the basis of social exchange theory, which our review shows is the dominant theory underlying assumptions about employee reactions to TM. We propose that 3 elements are missing in our current understanding, which can help explain our review findings: uncertainty, power, and social identity. We conclude with recommendations for TM research and practice.
Proteomic changes of the porcine skeletal muscle in response to chronic heat stress
Authors: Cui Yanjun , Hao Yue , Li Jielei , Gao Yanli , Gu Xianhong 
Published: December 2017

AbstractBACKGROUNDHeat stress (HS) has an adverse effect on meat quality; however, the underlying molecular mechanisms altering meat quality due to muscle responses to stress remain unclear. Sixteen castrated male crossbreeds between Landrace × Yorkshire sows and Duroc boars (79.00 ± 1.50 kg body weight) were exposed to either thermal neutral (22 °C, n = 8) or HS (30 °C, n = 8) conditions for 3 weeks. Subsequently, the longissimus dorsi (LD) muscle of all pigs was assayed for meat quality parameters and proteome analysis.RESULTSHS decreased post mortem (24 h) pH and intramuscular fat, changed ultimate L*, a* and b* values and increased drip loss and shear force. Proteome analysis of the LD was conducted by two‐dimensional gel electrophoresis and mass spectrometry. A total of 23 differentially expressed proteins were identified, of which three were verified by western blotting analysis. The identified proteins were involved in six types of biological process: carbohydrate metabolism, myofibrillar and cytoskeleton structure, stress response, antioxidant and detoxification, calcium binding and cellular apoptosis. Interestingly, HS induced higher levels of heat shock protein, antioxidants and calcium binding proteins, which are involved in the mechanisms of defense and homeostasis.CONCLUSIONThe results indicate that HS‐induced changes in the expression of myofibrillar proteins, glucose and energy metabolism‐related proteins, heat shock protein and antioxidant enzymes might, at least partly, contribute to increase in meat tenderness. These findings will provide the foundation for developing future mitigating solutions and preventative therapies to reduce the detrimental effects of chronic HS on muscle function, metabolism and meat quality. © 2017 Society of Chemical Industry
Ultrasensitive determination of highly polar trimethyl phosphate in environmental water by molecularly imprinted polymeric fiber headspace solid‐phase microextraction
Authors: Cai Cuicui , Zhang Pengcheng , Deng Jiali , Zhou Hongbin , Cheng Jing 
Published: December 2017

AbstractA sensitive, accurate, and cost effective method for the quantification of trimethyl phosphate, which is highly polar and volatile, in environmental water is presented. Trimethyl phosphate was headspace solid‐phase microextracted on a molecularly imprinted polymeric fiber, and then the fiber was thermally desorbed in the gas chromatograph injector, and the compound was determined. The trimethyl phosphate imprinted polymeric fiber was prepared by copolymerization in a fused silica capillary tube and obtained by removal of the wall of fused silica capillary tube. The monolithic fiber displayed good selectivity toward trimethyl phosphate among its structural analogues. It was thermally stable up to 320°C so that it can withstand the high temperature of the gas chromatograph injector for desorption. The factors influencing the performance of its headspace solid‐phase microextraction were studied. Under the optimal conditions, the method for quantification of trimethyl phosphate in environmental water was well developed. It exhibited significant linearity, the lowest limit of quantification to date, and good recoveries. Using this method, trimethyl phosphate was detected in five out of seven environmental water samples at concentration levels from 0.28 to 1.22 μg/L, illustrating the heavy pollution of trimethyl phosphate in environmental water.
Polysaccharide‐based chiral stationary phases as halogen bond acceptors: A novel strategy for detection of stereoselective σ‐hole bonds in solution
Authors: Peluso Paola , Mamane Victor , Dallocchio Roberto , Dessì Alessandro , Villano Rosaria , Sanna Daniele , Aubert Emmanuel , Pale Patrick , Cossu Sergio 
Published: December 2017

AbstractIn the last few years, halogen bonds have been exploited in a variety of research areas both in the solid state and in solution. Nevertheless, several factors make formation and detection of halogen bonds in solution challenging. Moreover, to date, few chiral molecules containing electrophilic halogens as recognition sites have been reported. Recently, we described the first series of halogen‐bond‐driven enantioseparations performed on cellulose tris(3,5‐dimethylphenylcarbamate) by high‐performance liquid chromatography. Herein the performances of amylose tris(3,5‐dimethylphenylcarbamate) as halogen bond acceptor were also investigated and compared with respect to cellulose tris(3,5‐dimethylphenylcarbamate). With the aim to explore the effect of polysaccharide backbone on the enantioseparations, the thermodynamic parameters governing the halogen‐dependent enantioseparations on both cellulose and amylose polymers were determined by a study at variable temperature and compared. Molecular dynamics were performed to model the halogen bond in polysaccharide‐analyte complexes. Chiral halogenated 4,4′‐bipyridines were used as test compounds (halogen bond donors). On this basis, a practical method for detection of stereoselective halogen bonds in solution was developed, which is based on the unprecedented use of high‐performance liquid chromatography as technical tool with polysaccharide polymers as molecular probes (halogen bond acceptors). The analytical strategy showed higher sensitivity for the detection of weak halogen bonds.
Effect of rural and urban geography on larynx cancer incidence and survival
Authors: Zuniga Steven A. , Lango Miriam N. 
Published: December 2017

Objectives/HypothesisInvestigate the impact of rural geography on larynx cancer incidence and survival.Study DesignSurveillance, Epidemiology, and End Results (SEER) database study.MethodsIncidence and survival rates by Rural–Urban Continuum codes for larynx squamous cell carcinoma patients diagnosed from 2004 to 2012 were evaluated using SEER statistical software and Cox proportional hazards survival analysis.ResultsThe lowest age‐adjusted incidence rates for larynx cancer were seen in densely populated urban regions, with mean rates of 2.8 per 100,000 person years (95% confidence interval [CI]: 2.7‐2.8); the highest were in the most rural areas, with mean rates of 5.3 per 100,000 person years (95% CI: 4.7‐5.9). Nevertheless, of 23,659 larynx cancer patients diagnosed over this period, 19,556 (82.7%) arose in urban residents, compared with 1,428 or 6% from rural areas. Urban larynx cancer patients more likely lived in counties with an American College of Surgeons–approved cancer center and/or a fourfold greater otolaryngology physician supply. Nevertheless, frequency of advanced stage at initial presentation was similar. Cause‐specific and overall survival were no different, both on univariable and multivariable analyses.ConclusionsCompared with urban populations, Rural populations are at greater risk of developing larynx cancer, but initial stage and survival after diagnosis are comparable. Priority should be given to prevention strategies to decrease incidence rates.Level of Evidence4 Laryngoscope, 1874–1880, 2018
Dialectical mind can be sweet toward crisis‐associated products/brands
Authors: Shi Bing , Wang Haizhong , Liu Wumei 
Published: December 2017

AbstractConsumers’ thinking style (e.g., dialectical thinking), which is fundamental to cognition, has been paid inadequate attention in the consumer literature. This research explores the impact of dialectical thinking on Chinese consumer responses toward crisis‐associated products/brands. Findings in three experimental studies indicate that, in comparison to those primed with nondialectical thinking, consumers primed with dialectical thinking report higher levels of purchase intention and trust for a crisis‐associated product/brand. This is the case not just for products with Chinese cultural background, but also for products with western cultural background. Consumers’ perceived severity of crises moderates the impact of dialectical thinking, with a stronger impact in a highly severe crisis situation than in a less severe one. A survey study indicates a similar pattern. These findings are important in suggesting ways of encouraging Chinese consumers to be insistent on quality standard in order to better protect their consumer rights, and moreover, for multinational corporations on how best to respond and formulate strategies of handling product‐harm crises in the Chinese market.
Oh my gosh, I got to get out of this place! A qualitative study of vicarious embarrassment in service encounters
Authors: Kilian Thomas , Steinmann Sascha , Hammes Eva 
Published: December 2017

AbstractVicarious embarrassment is a negative emotion, which is experienced by an individual when others misbehave. People can feel vicariously embarrassed when observing other people's pratfalls or awkward appearance. For instance, vicarious embarrassment is elicited when watching reality TV or in service encounters where many other customers are present. However, the relevance of vicarious embarrassment in physical service environments has not yet been thoroughly analyzed in the context of service encounters. The objective of the present study is to close this research gap and to introduce the phenomenon of vicarious embarrassment to service research. The findings of 25 in‐depth interviews indicate that vicariously embarrassing incidents mostly occur in service encounters and that these incidents are triggered by the violation of social norms in both customer‐to‐customer and customer‐to‐employee interactions. The authors of the present paper identified closeness of relationship, the service context, and parties involved as important situational variables influencing vicarious embarrassment and further emotional, cognitive, and behavioral consequences for the observing person. From a managerial point of view, the relevance of vicarious embarrassment in physical service environments is caused by negative spillover effects of the service experience, which lead to decreasing customer satisfaction, negative word‐of‐mouth and purchase intentions, and a negative impact on the overall image of the service provider.
Assessing hydrological impacts of climate change using bias‐corrected downscaled precipitation in Mae Klong basin of Thailand
Authors: Sharma Devesh , Babel Mukand S. 
Published: December 2017

ABSTRACTThe objective of the present study was to analyse the impacts of climate change on streamflow in the Mae Klong basin in Thailand using improved daily gridded precipitation data of the ECHAM4/OPYC global climate model. Bias correction and spatial downscaling methods are frequently used to improve global climate model precipitation. For bias correction, gamma−gamma transformation and ratio methods were used to correct the frequency and quantity of raw global circulation model (GCM) precipitation data. Spatial disaggregation, based on a multiplicative random cascade, was applied to downscale coarse resolution climate projected precipitation spatially. A rainfall‐runoff model (Hydrologic Engineering Center Hydrologic Modelling System, HEC‐HMS) was used to simulate future streamflow scenarios for three 5 year windows: the 2025s, the 2050s and the 2095s. The downscaling model parameters (β and σ2) were estimated separately for each month using the Mandelbrot−Kahane−Peyrière function. Both methods have proved useful in improving the quality, compared to historical trends and rainfall variability, of raw GCM precipitation data by reducing bias. There will not be much impact on water resources and water availability due to climate change in the coming decades in the Mae Klong River. There is some chance that, in the future, the monsoons will start before their regular period. There is also a chance of an increase in streamflow in the dry period and a decrease of streamflow in the wet period in the basin.
Extensions, dilations, and spectral problems of singular Hamiltonian systems
Authors: Allahverdiev Bilender P. 
Published: December 2017

In this paper, we construct a space of boundary values for minimal symmetric 1D Hamiltonian operator with defect index (1,1) (in limit‐point case at a(b) and limit‐circle case at b(a)) acting in the Hilbert space
In terms of boundary conditions at a and b, all maximal dissipative, accumulative, and self‐adjoint extensions of the symmetric operator are given. Two classes of dissipative operators are studied. They are called “dissipative at a” and “dissipative at b.” For 2 cases, a self‐adjoint dilation of dissipative operator and its incoming and outgoing spectral representations are constructed. These constructions allow us to establish the scattering matrix of dilation and a functional model of the dissipative operator. Further, we define the characteristic function of the dissipative operators in terms of the Weyl‐Titchmarsh function of the corresponding self‐adjoint operator. Finally, we prove theorems on completeness of the system of root vectors of the dissipative operators.
Physiological gas exchange mapping of hyperpolarized 129Xe using spiral‐IDEAL and MOXE in a model of regional radiation‐induced lung injury
Authors: Zanette Brandon , Stirrat Elaine , Jelveh Salomeh , Hope Andrew , Santyr Giles 
Published: December 2017

PurposeTo map physiological gas exchange parameters using dissolved hyperpolarized (HP) 129Xe in a rat model of regional radiation‐induced lung injury (RILI) with spiral‐IDEAL and the model of xenon exchange (MOXE). Results are compared to quantitative histology of pulmonary tissue and red blood cell (RBC) distribution.MethodsTwo cohorts (n = 6 each) of age‐matched rats were used. One was irradiated in the right‐medial lung, producing regional injury. Gas exchange was mapped 4 weeks postirradiation by imaging dissolved‐phase HP 129Xe using spiral‐IDEAL at five gas exchange timepoints using a clinical 1.5 T scanner. Physiological lung parameters were extracted regionally on a voxel‐wise basis using MOXE. Mean gas exchange parameters, specifically air‐capillary barrier thickness (δ) and hematocrit (HCT) in the right‐medial lung were compared to the contralateral lung as well as nonirradiated control animals. Whole‐lung spectroscopic analysis of gas exchange was also performed.Resultsδ was significantly increased (1.43 ± 0.12 μm from 1.07 ± 0.09 μm) and HCT was significantly decreased (17.2 ± 1.2% from 23.6 ± 1.9%) in the right‐medial lung (i.e., irradiated region) compared to the contralateral lung of the irradiated rats. These changes were not observed in healthy controls. δ and HCT correlated with histologically measured increases in pulmonary tissue heterogeneity (r = 0.77) and decreases in RBC distribution (r = 0.91), respectively. No changes were observed using whole‐lung analysis.ConclusionThis work demonstrates the feasibility of mapping gas exchange using HP 129Xe in an animal model of RILI 4 weeks postirradiation. Spatially resolved gas exchange mapping is sensitive to regional injury between cohorts that was undetected with whole‐lung gas exchange analysis, in agreement with histology. Gas exchange mapping holds promise for assessing regional lung function in RILI and other pulmonary diseases.
NMR elucidation of monomer–dimer transition and conformational heterogeneity in histone‐like DNA binding protein of Helicobacter pylori
Authors: Jaiswal Nancy , Raikwal Nisha , Pandey Himanshu , Agarwal Nipanshu , Arora Ashish , Poluri Krishna Mohan , Kumar Dinesh 
Published: December 2017

AbstractHelicobacter pylori (H. pylori) colonizes under harsh acidic/oxidative stress conditions of human gastrointestinal tract and can survive there for infinitely longer durations of host life. The bacterium expresses several harbinger proteins to facilitate its persistent colonization under such conditions. One such protein in H. pylori is histone‐like DNA binding protein (Hup), which in its homo‐dimeric form binds to DNA to perform various DNA dependent cellular activities. Further, it also plays an important role in protecting the genomic DNA from oxidative stress and acidic denaturation. Legitimately, if the binding of Hup to DNA is suppressed, it will directly impact on the survival of the bacterium, thus making Hup a potential therapeutic target for developing new anti‐H. pylori agents. However, to inhibit the binding of Hup to DNA, it is necessary to gain detailed insights into the molecular and structural basis of Hup‐dimerization and its binding mechanism to DNA. As a first step in this direction, we report here the nuclear magnetic resonance (NMR) assignments and structural features of Hup at pH 6.0. The study revealed the occurrence of dynamic equilibrium between its monomer and dimer conformations. The dynamic equilibrium was found to shifting towards dimer both at low temperature and low pH; whereas DNA binding studies evidenced that the protein binds to DNA in its dimeric form. These preliminary investigations correlate very well with the diverse functionality of protein and will form the basis for future studies aiming to develop novel anti‐H. pylori agents employing structure‐based‐rational drug discovery approach.
A local iterative approach for solving the stochastic Hamilton‐Jacobi‐Bellman equation (SHJBE) arising in the stochastic control of affine nonlinear systems
Authors: Aliyu M.D.S. 
Published: December 2017

SummaryIn this paper, local iterative methods for solving the stochastic Hamilton‐Jacobi‐Bellman equation arising in the stochastic optimal control of affine nonlinear systems are discussed. Superquadratic and quadratic convergence of the methods is established under fairly mild assumptions, and an example is solved to demonstrate the effectiveness of the methods. Finally, as a by‐product, an existence result for the solution to the stochastic Hamilton‐Jacobi‐Bellman equation is also established under the same assumptions.
Prenatal diagnosis of urinary tract anomalies, a cohort study in the Northern Netherlands
Authors: Bakker Marian K. , Bergman Jorieke E.H. , Fleurke‐Rozema Hanneke , Streefland Esther , Gracchi Valentina , Bilardo Caterina M. , De Walle Hermien E.K. 
Published: December 2017

AbstractObjectiveTo describe prevalence, time of diagnosis, and type of birth in children and fetuses with urinary tract (UT) anomalies after the introduction of the anomaly scan in the Netherlands in 2007.MethodsWe selected, from a population‐based congenital anomaly registry, children and fetuses with UT anomalies born between 2008 and 2014. Cases were defined according to type of UT anomaly and whether isolated or with associated anomalies. Information was collected on time of diagnosis and type of birth.ResultsWe included 487 cases. Total prevalence increased from 34.0 in 2008 to 42.3 per 10 000 births in 2014, mainly by an increase in anomalies of the collecting system. Almost 70% presented as isolated. Anomalies of the renal parenchyma were more often associated with genetic or other anomalies (47.3%) than anomalies of the collecting system (19.0%). The proportion of prenatally diagnosed cases increased from 59.3% in 2008 to 80.9% in 2014. Termination of pregnancy occurred in 14.8%, of which the majority were UT anomalies associated with a genetic disorder or other anomalies.ConclusionIn the period after the introduction of the anomaly scan, we observed an increasing prevalence of anomalies of the collecting system, but no increase in termination of pregnancies.