bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain angiogenic gene expression in fetuses with congenital heart disease
Authors: Sánchez O. , Ruiz‐Romero A. , Domínguez C. , Ferrer Q. , Ribera I. , Rodríguez‐Sureda V. , Alijotas J. , Arévalo S. , Carreras E. , Cabero L. , Llurba E. 
Published: December 2017

ABSTRACTObjectiveTo assess potential differences in the expression of antiangiogenic and angiogenic factors and of genes associated with chronic hypoxia in cerebral tissue of euploid fetuses with congenital heart disease (CHD) vs those without.MethodsCerebral tissue was obtained from 15 fetuses with CHD and 12 control fetuses that had undergone termination of pregnancy. Expression profiles of the antiangiogenic factor soluble fms‐like tyrosine kinase‐1 (sFlt‐1), the angiogenic vascular endothelial growth factor‐A (VEGF‐A) and placental growth factor (PlGF), and of genes associated with chronic hypoxia were determined by real‐time polymerase chain reaction in tissue from the frontal cortex and the basal ganglia of the fetuses.ResultsExpression of sFlt‐1 was 48% higher in the frontal cortex (P = 0.0431) and 72% higher in the basal ganglia (P = 0.0369) of CHD fetuses compared with controls. The expression of VEGF‐A was 60% higher (P = 0.0432) and that of hypoxia‐inducible factor 2‐alpha was 98% higher (P = 0.0456) in the basal ganglia of CHD fetuses compared with controls. No significant differences were observed between the two groups in the expression of PlGF and hypoxia‐inducible factor 1‐alpha.ConclusionAn overall dysregulation of angiogenesis with a net balance towards an antiangiogenic environment was observed in the cerebral tissue of fetuses with CHD, suggesting that these fetuses may have an intrinsic angiogenic impairment that could contribute to impaired brain perfusion and abnormal neurological development later in life. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
In silicotoxicology: comprehensive benchmarking of multi‐label classification methods applied to chemical toxicity data
Authors: Raies Arwa B. , Bajic Vladimir B. 
Published: December 2017

One goal of toxicity testing, among others, is identifying harmful effects of chemicals. Given the high demand for toxicity tests, it is necessary to conduct these tests for multiple toxicity endpoints for the same compound. Current computational toxicology methods aim at developing models mainly to predict a single toxicity endpoint. When chemicals cause several toxicity effects, one model is generated to predict toxicity for each endpoint, which can be labor and computationally intensive when the number of toxicity endpoints is large. Additionally, this approach does not take into consideration possible correlation between the endpoints. Therefore, there has been a recent shift in computational toxicity studies toward generating predictive models able to predict several toxicity endpoints by utilizing correlations between these endpoints. Applying such correlations jointly with compounds' features may improve model's performance and reduce the number of required models. This can be achieved through multi‐label classification methods. These methods have not undergone comprehensive benchmarking in the domain of predictive toxicology. Therefore, we performed extensive benchmarking and analysis of over 19,000 multi‐label classification models generated using combinations of the state‐of‐the‐art methods. The methods have been evaluated from different perspectives using various metrics to assess their effectiveness. We were able to illustrate variability in the performance of the methods under several conditions. This review will help researchers to select the most suitable method for the problem at hand and provide a baseline for evaluating new approaches. Based on this analysis, we provided recommendations for potential future directions in this area.This article is categorized under:Computer and Information Science > ChemoinformaticsComputer and Information Science > Computer Algorithms and Programming
Wind and solar resource data sets
Authors: Clifton Andrew , Hodge Bri‐Mathias , Draxl Caroline , Badger Jake , Habte Aron 
Published: December 2017

The range of resource data sets spans from static cartography showing the mean annual wind speed or solar irradiance across a region to high temporal and high spatial resolution products that provide detailed information at a potential wind or solar energy facility. These data sets are used to support continental‐scale, national, or regional renewable energy development; facilitate prospecting by developers; and enable grid integration studies. This review first provides an introduction to the wind and solar resource data sets, then provides an overview of the common methods used for their creation and validation. A brief history of wind and solar resource data sets is then presented, followed by areas for future research. WIREs Energy Environ 2018, 7:e276. doi: 10.1002/wene.276This article is categorized under:

Wind Power > Climate and Environment
Solar Heating and Cooling > Climate and Environment
Energy Infrastructure > Climate and Environment
From the Trauma of Stalinism to the Triumph of Stalingrad: The Toponymic Dispute Over Volgograd
Authors: Kangaspuro Markku , Lassila Jussi 
Published: December 2017

Abstract
This chapter examines the Putin-era debates over the name of Volgograd/Stalingrad, the site of the historic Battle of Stalingrad. The case of the symbolic politics around the name of this city offers rich material for studying the dynamics of triumph and trauma in Russia. While the theme of Stalingrad continues to represent the core symbol of national triumph, it also inescapably refers to the most acute trauma of the state’s past: the Stalin era. The chapter shows how the debate over the name of Stalingrad reveals a twofold, and somewhat paradoxical, dynamic between the state’s bid for hegemony, on the one hand, and the inexorable pluralization of commemorations of the national past in today’s Russia, on the other.
The Drone Sector in Europe
Authors: de Miguel Molina Blanca , Segarra Oña Marival 
Published: December 2017

AbstractThe aim of this chapter is to review the industry sector in Europe, which involves big companies as well as SMEs. The leading European countries, the main competitors, and the main competitive advantages of the industry are analysed. We have identified five different segments in which companies compete based on distinctive features (toys, hobby/leisure, professional, commercial, and military). The homogenization of the industry, especially in the toy, hobby, and commercial subsectors, is mainly led by big companies, which at the same time also represent the largest market share. We have concluded that there are no entry barriers besides technology and commercial distribution, but the main difficulty that is hampering the industry’s expansion is regulation. This affects in particular the hobby/leisure and commercial drone segments, some areas more than others; while agricultural and military drones are expanding and evolving rapidly, professional filming and photography and toys are still too dependent on safety or legal issues, such as privacy concerns. It is also remarkable that companies from China and the USA are reaching the top positions. This should be taken into consideration by European policy makers, as the decisions made in the next years will be the key to the development of the sector in Europe.
Nieuw gedachtegoed te over
Authors: van der Poel Henk G. 
Published: December 2017

Samenvatting
Opnieuw overvloedig veel nieuwe gedachten en voer voor discussie in dit abstractnummer. De selectiecriteria van de PRIAS-studie zijn er niet voor niets: tumoren die er niet aan voldoen, hebben echt slechtere histologie na prostatectomie en de beoordeling van een positief chirurgisch snijvlak blijft subjectief en mogelijk een minder goede kwaliteitsmaat.
Abstracts najaarsvergadering NVU, 3 november 2017, Nieuwegein
Authors: van der Poel Henk G. 
Published: December 2017

Samenvatting
De studie had tot doel om te bepalen of preoperatieve anatomische structuren van prostaat en kleine bekken, en intraoperatieve fascie preservatie (FP), herstel van continentie voorspellen na robotgeassisteerde laparoscopische prostatectomie (RARP).
Understanding ownership of patient care: A&nbsp;dual-site qualitative study of faculty and residents from medicine and psychiatry
Authors: Cowley Deborah S. , Markman Jesse D. , Best Jennifer A. , Greenberg Erica L. , Grodesky Michael J. , Murray Suzanne B. , Corning Kelli A. , Levy Mitchell R. , Greenberg William E. 
Published: December 2017

Introduction With changes in duty hours and supervision requirements, educators have raised concerns about erosion of patient care ownership by resident physicians. However, the definition of ownership is unclear. This qualitative study investigated definitions of ownership in medicine and psychiatry faculty and residents.
Methods The authors distributed an anonymous online survey regarding definitions of ownership to faculty and residents at the psychiatry and internal medicine residency programs at the University of Washington and the Harvard Longwood psychiatry residency and conducted a qualitative analysis of free-text responses to identify emergent themes.
Results 225 faculty (48.6%) and 131 residents (43.8%) across the three programs responded. Responses yielded themes in five domains: Physician Actions, Physician Attitudes, Physician Identity, Physician Qualities, and Quality of Patient Care. All groups identified themes of advocacy, communication and care coordination, decision-making, follow through, knowledge, leadership, attitudes of going ‘above and beyond’ and ‘the buck stops here’, responsibility, serving as primary provider, demonstrating initiative, and providing the best care as central to ownership. Residents and faculty had differing perspectives on ‘shift work’ and transitions of care and on resident decision-making as elements of ownership.
Discussion This study expanded and enriched the definition of patient care ownership. There were more similarities than differences across groups, a reassuring finding for those concerned about a decreasing understanding of ownership in trainees. Findings regarding shared values, shift work, and the decision-making role can inform educators in setting clear expectations and fostering ownership despite changing educational and care models.
Tunneled Catheter Placement in a Pediatric Patient: A Novel Approach
Authors: Goel Dewansh , Yadav Bhupender , Lewis Paul , Sharma Karun , Vellody Ranjith 
Published: December 2017

Abstract
Establishing venous access can be an important and often complex aspect of care for pediatric patients. When stable central venous access is required for long-term intravenous infusions, several options are available including peripherally inserted central catheters (PICC), tunneled catheters and ports. Both PICC placement and tunneled catheter placement include an exposed external segment of catheter, either in an extremity or on the chest. We present a pediatric patient with complex behavioral history who required long-term intravenous therapy. After careful review, the best option for the patient was determined to be a tunneled catheter that exited the skin in the right upper back, making it difficult to grab and pull out. The catheter was successfully placed and the patient appropriately completed his intravenous antibiotic course. Upon completion, the catheter was removed without complications. This tunneling technique to the scapular region may be useful for patients with psychiatric or neurodegenerative disorders where purposeful dislodgement may be a problem.
First results of study of Lake Baunt bottom sediments (northern Transbaikalia)
Authors: Krainov M.A. , Bezrukova E.V. , Kerber E.V. , Levina O.V. , Ivanov E.V. , Shchetnikov A.A. , Filinov I.A. 
Published: December 2017

Abstract
In March 2014, the Lake Baunt bottom sediments were drilled in the deepest part of the lake basin (33 m). The penetrated interval is 13.7 m thick, with the age of the base being evaluated at 28–30 ka. Lithological study of the penetrated sediments demonstrates the upper part of the section dominated by diatom ooze, whose concentration decreases gradually downward the section, up to the replacement of the ooze by silty clay. The obtained data on variations in petromagnetic parameters, concentration of biogenic silica, and sediment compaction indicate considerable variations of sedimentary environments during the Late Pleistocene and Holocene. Being compared with the previously reconstructed landscape and climate dynamics for the sedimentary succession of Lake Kotokel for this time interval, the above parameters reveal that the Lake Baunt bottom sediments reliably fix the regional paleoclimate signal. For the first time for lakes of the Baikal region, Gothenburg and Mono Lake magnetic excursions are identified in the paleomagnetic record of the Lake Baunt section.
Analysis and experimental validation of morphing UAV wings
Authors: Chanzy Q. , Keane A.J. 
Published: December 2017

ABSTRACTThe development of new technologies – such as rapid prototyping – and the use of materials with improved properties – such as highly resistant extruded polystyrene foam which can be easily and precisely shaped, while conserving its mechanical properties – allow researchers to improve design concepts. This article details the development of a new set of morphing wings for a 15-kg maximum take-off weight Unmanned Aerial Vehicle (UAV) from concept design, to flight tests, including modelling, design optimisation, construction and wind-tunnel tests. A set of comparator-equivalent conventional wings have been used throughout in order to be able to judge any benefits stemming from the adoption of morphing technology. This article shows that the morphing wings provide a controllable aircraft while reducing drag by a factor of 40% compared to the comparator wings with conventional ailerons in a deflected position.
Octreotide for the treatment of intentional insulin aspart overdose in a non-diabetic patient
Authors: Dewaal Catherine M. , McGillis Eric , Mink Matt , Lucyk Scott 
Published: December 2017

AbstractIntentional insulin overdose may lead to severe and refractory hypoglycemia. Exogenous dextrose administration is the mainstay of therapy for these patients and is effective in most cases. However, in patients with a functional pancreas, exogenous dextrose administration may precipitate endogenous insulin release leading to rebound hypoglycemia. We describe a case report of a 41-year-old woman who injected 300 units of insulin aspart with suicidal intent. Her initial blood glucose was 2.3 mmol/L (41 mg/dL). Over the next 12 hours, she experienced recurrent hypoglycemic episodes despite 10% dextrose infusions and 14 ampoules of 50% dextrose. Our patient experienced complications, including peripheral edema, related to the large volumes of intravenous dextrose required to attempt to maintain euglycemia. Octreotide, a somatostatin analogue, may help prevent dextrose-induced hypoglycemia and improve the management in select insulin overdose patients; large infusion volumes resulted in significant peripheral edema. Treatment with octreotide was initiated 12.5 hours post-injection and was followed by a stabilization of blood glucose concentration in this non-diabetic patient.
Comparison of the meteorology and surface energy fluxes of debris-free and debris-covered glaciers in the southeastern Tibetan Plateau
Authors: YANG WEI , YAO TANDONG , ZHU MEILIN , WANG YONGJIE 
Published: December 2017

ABSTRACTKnowledge of debris-free and debris-covered glaciers is important for understanding the varying response of glaciers to climate change. Measurements at the debris-free Parlung No. 4 Glacier and the debris-covered 24 K Glacier in the southeastern Tibetan Plateau were carried out to compare the meteorology and surface energy fluxes and to understand the factors controlling the melting process. The meteorological comparisons displayed temporally synchronous fluctuations in air temperature, relative humidity and incoming longwave radiation (Lin), but notable differences in precipitation, incoming shortwave radiation (Sin) and wind speed. Under the prevailing regional precipitation and debris conditions, more Lin (42 W m−2) was supplied from warmer and more humid air and more Sin (58 W m−2) was absorbed at the 24 K Glacier. The relatively high energy supply led mainly to an increased energy output via turbulent heat fluxes and outgoing longwave radiation, rather than glacier melting beneath the thick debris. The sensitivity experiment showed that melt rates were sensitive to energy supply at debris thicknesses <~10 cm. In contrast, energy supply to the Parlung No. 4 Glacier mainly resulted in snow/ice melting, the magnitude of which was significantly influenced by energy supplied by Sin and the sensible heat flux.
A new late Carboniferous coleoid from Oklahoma, USA: implications for the early evolutionary history of the subclass Coleoidea (Cephalopoda)
Authors: Doguzhaeva Larisa A. , Mapes Royal H. 
Published: December 2017

AbstractThe limited record of the bactritoid-like coleoid cephalopods is here expanded due to discovery of a late Carboniferous (Moscovian) orthocone comprising a phragmocone and a body chamber with a proostracum-like structure, a sheath-like rostrum, an ink sac, and a muscular mantle preserved on top of the conch. The specimen comes from the Wewoka Formation in the vicinity of the city of Okmulgee, Oklahoma, which previously yielded an orthocone indicative of an evolutionary branch of the Carboniferous cephalopods described as the order Donovaniconida Doguzhaeva, Mapes, and Mutvei, 2007a within the subclass Coleoidea Bather, 1888. Here, we describe from that site a bactritoid-like coleoid,Oklaconus okmulgeensisn. gen. n. sp. in Oklaconidae n. fam. A broad lateral lobe of the suture line and a compressed conch with a narrowed dorsal side and a broadly rounded ventral side distinguish this genus fromDonovaniconusDoguzhaeva, Mapes, and Mutvei, 2002b. The muscular mantle is preserved as a dense sheet-like structure, with a crisscross pattern and a globular-lamellar ultrastructure. Recent knowledge on the early to late Carboniferous coleoids is discussed. Carboniferous coleoids show a high morphological plasticity with a capacity for being altered to create the diverse combinations of ‘bactritoid’ and ‘coleoid’ structures. This could be the principle evolutionary driver of their radiation in the late Carboniferous.
Technological Innovation Research in China and India: A Bibliometric Analysis for the Period 1991–2015
Authors: Chatterjee Debabrata , Sahasranamam Sreevas 
Published: December 2017

ABSTRACTAlthough a substantial literature on the management of technological innovation exists, several scholars argue that much of this research has been rooted in Western contexts, where key assumptions are very different from those in emerging economies. Building on this viewpoint, we investigate the current state of knowledge on technological innovation in two of the largest and fastest growing emerging economies: China and India. We undertook a bibliometric analysis of author keywords and combined different quantitative approaches – frequency analysis, cluster analysis, and co-word analysis – to review 162 articles on technological innovation published about China and India for the period 1991–2015. From the analyses, the trends in technological innovation research in the two countries and the dominant themes of discussion were identified. These themes were further classified into eight sub-themes. Our key findings indicate a near absence of research on the management of technological innovation based on India, limited volume of research on indigenous aspects of innovation, and a lack of theory-building based on these countries’ contexts. Several suggestions for future research are offered based on the gaps identified.
Failure to detect the action of antidepressants in the forced swim test in Swiss mice
Authors: Suman Patrick R. , Zerbinatti Nathalia , Theindl Lais Cristina , Domingues Karolina , Lino de Oliveira Cilene 
Published: December 2017

ObjectiveThe aims of this study were to replicate previously published experiments and to modify the protocol to detect the effects of chronic antidepressant treatment in mice.MethodsMale Swiss mice (n=6–8/group) housed in reversed light/dark cycle were randomly assigned into receive vehicle (10% sucrose), sub-effective doses (1 and 3 mg/kg) or effective doses (10 and 30 mg/kg) of bupropion, desipramine, and fluoxetine and a candidate antidepressant, sodium butyrate (1–30 mg/kg) per gavage (p.o.) 1 h before the forced swim test (FST). Treatments continued daily for 7 and 14 days during retests 1 and 2, respectively. In an additional experiment, mice received fluoxetine (20 mg/kg) or vehicle (10% sucrose or 0.9% saline) p.o. or i.p. before the FST. Mice housed in reversed or standard light/dark cycles received fluoxetine (20 mg/kg) prior FST. Video recordings of behavioural testing were used for blind assessment of the outcomes.ResultsAccording to the expected, doses of antidepressants considered sub-effective failed to affect the immobility time of mice in the FST. Surprisingly, acute and chronic treatment with the high doses of bupropion, desipramine, and fluoxetine or sodium butyrate also failed to reduce the immobility time of mice in the FST. Fluoxetine 20 mg/kg was also ineffective in the FST when injected i.p. or in mice housed in normal light/dark cycle.ConclusionData suggest the lack of efficacy of orally administered bupropion, desipramine, fluoxetine in the FST in Swiss mice. High variability, due to high and low immobility mice, may explain the limited effects of the treatments.
The validity of a web-based FFQ assessed by doubly labelled water and multiple 24-h recalls
Authors: Medin Anine C. , Carlsen Monica H. , Hambly Catherine , Speakman John R. , Strohmaier Susanne , Andersen Lene F. 
Published: December 2017

AbstractThe aim of this study was to validate the estimated habitual dietary intake from a newly developed web-based FFQ (WebFFQ), for use in an adult population in Norway. In total, ninety-two individuals were recruited. Total energy expenditure (TEE) measured by doubly labelled water was used as the reference method for energy intake (EI) in a subsample of twenty-nine women, and multiple 24-h recalls (24HR) were used as the reference method for the relative validation of macronutrients and food groups in the entire sample. Absolute differences, ratios, crude and deattenuated correlations, cross-classifications, Bland–Altman plot and plots between misreporting of EI (EI–TEE) and the relative misreporting of food groups (WebFFQ–24HR) were used to assess the validity. Results showed that EI on group level was not significantly different from TEE measured by doubly labelled water (0·7 MJ/d), but ranking abilities were poor (r −0·18). The relative validation showed an overestimation for the majority of the variables using absolute intakes, especially for the food groups ‘vegetables’ and ‘fish and shellfish’, but an improved agreement between the test and reference tool was observed for energy adjusted intakes. Deattenuated correlation coefficients were between 0·22 and 0·89, and low levels of grossly misclassified individuals (0–3 %) were observed for the majority of the energy adjusted variables for macronutrients and food groups. In conclusion, energy estimates from the WebFFQ should be used with caution, but the estimated absolute intakes on group level and ranking abilities seem acceptable for macronutrients and most food groups.