bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Ratiometric Fluorescence Assay for Detection of Ascorbic Acid Based on N,S Co‐Doped Carbon Dots Combined With Ce4+
Authors: Hu Congcong , Wang Wenjuan , Li Qianwen , Liu Bin , Xiao Fubing , Liu Jinquan , Yang Shengyuan 
Published: October 2024

ABSTRACTHence, N,S‐CDs with photoluminescent property were simply synthesized via a one‐step hydrothermal method. Combined with the commercial reagent Ce4+, a ratiometric fluorescence assay for ascorbic acid (AA) detection was established. Ce4+, possessing oxidization, could directly oxidize o‐phenylenediamine (OPD) to form the yellow fluorescent product oxOPD. Under the excitation wavelength of 370 nm, oxOPD had a maximum fluorescence emission at 562 nm. Meanwhile, due to the occurrence of the inner filter effect (IFE), oxOPD quenched the fluorescence of N,S‐CDs. However, ascorbic acid (AA) inhibited the oxidation of Ce4+, causing the fluorescence of oxOPD at 562 nm to decrease, accompanied by an increase in the fluorescence belonging to N,S‐CDs at 450 nm. Thus, a Ce4+‐assisted ratiometric fluorescence method was established for AA detection. The two fluorescence output signals in this method had opposite changing trends, which could reduce system errors and improve the accuracy. This method was successfully applied to the determination of AA in drugs and fruits.
Haloxylon salicornicum Phytochemicals Suppress NF‐κB, iNOS and Pro‐Inflammatory Cytokines in Lipopolysaccharide‐Induced Macrophages
Authors: Alruhaimi Reem S. , Hussein Omnia E , Alnasser Sulaiman M. , Elbagory Ibrahim , Alzoghaibi Mohammed A. , Kamel Emadeldin M. , El Mohtadi Mohamed , Mahmoud Ayman M. 
Published: October 2024

AbstractHaloxylon salicornicum is traditionally used for the treatment of several disorders associated with inflammation. Despite it is a defense response against tissue injury and infections, inflammation can become a chronic condition that can negatively impact the body. This study investigated the effect of H. salicornicum phytochemicals nuclear factor‐kappaB (NF‐κB), inducible nitric oxide synthase (iNOS) and cytokines release by lipopolysaccharide (LPS)‐challenged macrophages in vitro. The binding affinity of the tested phytochemical towards NF‐κB and iNOS was investigated using molecular docking. Ten compounds (four coumarins, three sterols and three flavonoids) were isolated from the ethanolic extract of H. salicornicum. Treatment of LPS‐challenged macrophages with the compounds resulted in remarkable decrease in NF‐κB p65 and iNOS mRNA abundance. All compounds suppressed the production of nitric oxide (NO) and the pro‐inflammatory cytokines (tumor necrosis factor (TNF)‐α and interleukin (IL)‐6) from macrophages challenged with LPS. Molecular docking revealed the ability of the isolated phytochemicals to bind NF‐κB p65 and iNOS. In conclusion, H. salicornicum is a rich source of phytochemicals with anti‐inflammatory properties. The anti‐inflammatory efficacy of H. salicornicum phytoconstituents is mediated via their ability to modulate NF‐κB and iNOS, and suppress the release of NO, TNF‐α, and IL‐6 from macrophages.
Optimizing Transfection Efficiency of Spermine Polar Head Cholesterol‐Based Cationic Lipids with Amino Acid Linker
Authors: Thongbamrer Chopaka , Kunkeaw Nawapol , Nguitragool Wang , Roobsoong Wanlapa , Sattabongkot Jetsumon , Opanasopit Praneet , Yingyongnarongkul Boon‐ek 
Published: October 2024

AbstractIn this work, a series of spermine polar head cholesterol‐based cationic lipids with various amino acid spacers were synthesized and evaluated as non‐viral gene delivery systems. The physicochemical properties of the resulting lipoplexes, formed from these lipids and DOPE, were assessed, including zeta‐potential, DNA binding and DNA protection from serum. Transfection efficiency and cytotoxicity were examined under serum‐free and 10–40 % serum‐containing conditions. The results showed that the physicochemical properties of cationic lipids, both with and without amino acid spacers, were not significantly different. Cationic liposomes composed of lipid Sper‐Ahx‐Chol, which has a 6‐aminohexanoic acid spacer, and DOPE exhibited greater transfection efficiency in HeLa cells compared to Lipofectamine3000, both in the absence and presence of 10–40 % serum. Additionally, lipid Sper‐His‐Chol with a histidine spacer and Sper‐Ahx‐Chol showed higher efficiency than Lipofectamine3000 against HEK293T under 40 % serum conditions. These results suggest that the incorporation of amino acids into the cationic lipids can significantly enhance their DNA delivery efficiency. Specifically, certain amino acid modifications improved transfection efficiency while maintaining low cytotoxicity. Our findings highlight the potential of amino acid‐tailored cationic lipids as promising vectors for enhanced DNA delivery.
Challenges in the diagnosis and management of dry tamponade
Authors: Tiwana Jasleen , Kearney Kathleen E. , Lombardi William L. , Azzalini Lorenzo 
Published: October 2024

AbstractDry tamponade is a rare complication of percutaneous coronary intervention. It encompasses a heterogenous pathophysiology and is used to describe hemodynamic compromise secondary to a coronary artery perforation, without free‐flowing fluid in the pericardium. Tamponade physiology can result from compressive epicardial, intramyocardial, subepicardial hematomas, or dissecting intramyocardial hematomas. The diagnosis of dry tamponade requires hemodynamic derangement in the context of a compressive hematoma as demonstrated by imaging. Although echocardiography can often help identify dry tamponade, additional studies including right heart catheterization, computed tomography, or cardiac magnetic resonance imaging can inform the exact mechanism and help guide management. This article describes a case of dry tamponade, reviews the existing literature on the topic, and offers expert recommendations on diagnosis and management.
Carina: A major determinant in the pathophysiology and treatment of coronary bifurcation lesions
Authors: Zuin Marco , Chiastra Claudio , Morbiducci Umberto , Gallo Diego , Bilato Claudio , Rigatelli Gianluca 
Published: October 2024

AbstractOver the last decade, several in vivo and computational investigations have significantly advanced our understanding of the pathophysiology of coronary bifurcations, contributing to the enhancement of their percutaneous revascularization. The carina of the coronary bifurcations plays a substantial role in generating their main hemodynamic features, including distinctive flow patterns with secondary flows and specific shear stress patterns. These factors play a pivotal role in determining the susceptibility, development, and progression of atherosclerosis. The underlying pathophysiological mechanisms of atherosclerosis in coronary bifurcations are complex and multifactorial. Understanding these mechanisms is fundamental to comprehending lesions at the bifurcation level and informing future treatment strategies. This review aims to present the currently available data regarding the pathophysiological and prognostic role of the carina in coronary bifurcations, offering an interpretation of these findings from the perspective of interventional cardiologists, providing valuable insights for their clinical practice.
Multilevel Dynamic System as Molecular Morning‐After Timer
Authors: Riera Micaela B. , Salazar Mario O. , Furlan Ricardo L. E. 
Published: October 2024

AbstractSystems chemistry aims to develop molecular systems that display emerging properties arising from their network and absent in their individual constituents. Employing reversible chemistry under thermodynamic control represents a valuable tool for generating dynamic combinatorial libraries of interconverting molecules, which may exhibit intriguing collective behaviour. A simple dynamic combinatorial library was prepared using dithioacetal/thiol/disulfide exchanges. Because of the relative reactivities of these reversible reactions, the library constitutes a two‐layer dynamic system with one layer active in an acid medium (thiol/dithioacetal exchange) and one layer active in a basic medium (thiol/disulfide exchange). This property enables the system to respond to momentary changes in acidity of the medium by activating different network regions, channeling some building blocks from one layer to another through shared thiol reagents (nodes). This momentaneous change in wiring affects the final steady state composition of the library, measured the next day, even though the event that caused it vanishes without leaving any residue. Therefore, the final composition of this dynamic system provides information about this transient past perturbation in the environment such as: when it occurred, how long it was, or how intense it was.
Ammonothermal Synthesis of Luminescent Imidonitridophosphate Ba4P4N8(NH)2:Eu2+
Authors: Engelsberger Florian M. , Pritzl Reinhard M. , Steinadler Jennifer , Witthaut Kristian , Bräuniger Thomas , Schmidt Peter J. , Schnick Wolfgang 
Published: October 2024

AbstractThe structural variability of a compound class is an important criterion for the research into phosphor host lattices for phosphor‐converted light‐emitting diodes (pc‐LEDs). Especially, nitridophosphates and the related class of imidonitridophosphates are promising candidates. Recently, the ammonothermal approach has opened a systematic access to this substance class with larger sample quantities. We present the successful ammonothermal synthesis of the imidonitridophosphate Ba4P4N8(NH)2:Eu2+. Its crystal structure is solved by X‐ray diffraction and it crystallizes in space group Cc (no. 9) with lattice parameters a=12.5250(3), b=12.5566(4), c=7.3882(2) Å and β=102.9793(10)°. For the first time, adamantane‐type (imido)nitridophosphate anions [P4N8(NH)2]8− are observed next to metal ions other than alkali metals in a compound. The presence of imide groups in the structure and the identification of preferred positions for the hydrogen atoms are performed using a combination of quantum chemical calculations, Fourier‐transform infrared, and solid‐state NMR spectroscopy. Eu2+ doped samples exhibit cyan emission (λmax=498 nm, fwhm=50 nm/1981 cm−1) when excited with ultraviolet light with an impressive internal quantum efficiency (IQE) of 41 %, which represents the first benchmark for imidonitridophosphates and is promising for potential industrial application of this compound class.
Investigation on the influence of particle size and porosity on solid phase fluidization and heat transfer in carbon fibre porous media
Authors: Wang Licheng , Zhang Wenwen , Yang Zhouzhe 
Published: October 2024

AbstractIn this paper, the 3D pore structure was reconstructed and solid phase fluidization in porous media was investigated. Based on the two fluid model, a computational fluid dynamics (CFD) model of gas–solid fluidization was established and the influence of particle size and porosity were investigated. When porosity was constant, during the fluidization process, the particle velocity and solid concentration standard deviation gradually decreased, and the bed height increased. At the same time, the smaller the particle size was, the smaller the solid concentration standard deviation was, the faster the bed height increased, and the more the particle temperature decreased. Based on the fixed value of particle size, when studying the effect of porosity on fluidization, it was found that with the enhancement of solid‐phase fluidization, particle velocity, solid concentration standard deviation, and particle temperature decreased, and bed height increased. Moreover, when porosity was large, particle velocity decreased rapidly, and solid concentration standard deviation reached a smaller minimum value, which took a longer time. Within the same time, the particle temperature also decreased less.
A physics‐constrained hybrid residual neural network for the prediction of moisture content in a closed‐cycle drying system
Authors: Zhou Mengfei , Wang Ruizhen , Cheng Rong , Sun Qin , Yu Qiqing , Xia Luyue , Sun Xiaofang 
Published: October 2024

AbstractClosed‐cycle drying technology has the advantages of safety, energy saving, and environmental protection, and has a wide application prospect. Due to the multi‐physics and multi‐scale nature of heat/mass transfer in the closed‐cycle drying process, as well as the characteristics of drying medium circulation and energy integration, it is difficult to obtain the product moisture content prediction model in closed‐cycle process based on rigorous closed‐cycle drying process mechanism model. However, accurate monitoring of product moisture content in the closed‐cycle drying process is the key to improving drying quality and process optimization. Aiming at the challenges in predicting moisture content, this paper proposes a physics‐constrained hybrid residual neural network (PC‐HRNN) for soft sensor modelling within a designed closed‐cycle drying system. The characteristic of this proposed method lies in its effective fusion of physics, knowledge, and data. First, a hybrid residual neural network (HRNN) is constructed based on the integration of a physics model and a data‐driven model. The HRNN takes the knowledge from the physics model as its auxiliary features and learns the prediction residuals of the physics model through a neural network model. Then, a new loss function that takes into account physical laws is introduced into HPNN to standardize model training and improve the generalization performance of the model. The experimental results show that the PC‐HRNN model improves prediction accuracy and model robustness, reduces the demand for data, and demonstrates stronger extrapolation capabilities under limited data.
Photocatalytic Aldehyde Allylation for Site‐Specific DNA Functionalization
Authors: Zhang Yixin , Huang Ying , Che Qiaoling , Chen Yiyun 
Published: October 2024

Comprehensive SummaryEnhancing the DNA toolbox with innovative photochemical reactions is pivotal for advancing nucleic acid‐based technologies. Aldehyde groups, versatile bioorthogonal handles for imine formation under acidic conditions, are particularly valuable due to their roles in nucleic acid epigenetics. Here, we present the first photocatalytic on‐DNA aldehyde allylation, enabling precise DNA functionalization under mild, neutral aqueous conditions. Our approach utilizes a photocatalytic polarity‐reversal reaction between DNA‐conjugated benzaldehydes and allyl sulfones. This reaction demonstrates exceptional chemoselectivity while preserving DNA integrity. By varying allyl sulfones, we achieve site‐specific labeling of non‐native DNA with the aldehyde group and cross‐linking with DNA‐bearing allyl sulfones. Furthermore, our method facilitates selective labeling and pull‐down enrichment of 5‐formylpyrimidine nucleotides among complex cellular DNA. This photocatalytic on‐DNA aldehyde transformation expands the limited bioorthogonal photochemical toolboxes, providing novel avenues for functionalizing both non‐native and native aldehyde modifications on DNA.
A Hardware Circuit for Extracting Weak Damage Characteristics of Steel Wire Rope Using an Asymmetric Monostable System
Authors: Huang Shengping , Liu Zihan , Li Ao , Yang Jianhua , Sanjuán Miguel A. F. , Wang Zhongqiu 
Published: October 2024

ABSTRACTNon‐destructive testing of steel wire rope is significant in lifting machinery. However, it is still challenging to extract weak damage characteristics of steel wire rope under noise caused by harsh working conditions. Currently, extracting damage characteristics mostly involves secondary processing through software, which is cumbersome and inefficient. Stochastic resonance is a typical stochastic dynamic phenomenon of a nonlinear system, and it can extract weak damage characteristics through the cooperation of noise, weak signals, and nonlinear system models. Among different nonlinear system models, the asymmetric monostable system, which has only one fixed point, is advantageous for achieving a more stable response under pulse excitation. In this work, a hardware circuit based on an asymmetric monostable system is constructed to extract weak damage characteristics of steel wire rope. This hardware circuit can efficiently extract damage characteristics without secondary processing. Additionally, the denoising performance of the nonlinear circuit, focusing on weak signals with damage characteristics under a noisy background, is evaluated using the cross‐correlation coefficient and local cross‐correlation coefficient. The results demonstrate that the proposed method provides high recovery in the non‐destructive testing of steel wire rope.
Characterization of the reproductive strategy of invasive Round Goby (Neogobius melanostomus) in the Upper Danube River
Authors: Klarl Melina , Pander Joachim , Geist Juergen 
Published: October 2024

AbstractOriginating from the Black and Caspian seas, the Round Goby (Neogobius melanostomus) has become one of the most successful invaders of freshwater ecosystems. In this study, we provide a characterization of the reproductive strategy of an established population of Round Gobies in the Upper Danube river including sex ratio, fluctuations of gonadosomatic index (GSI), analysis of timing of spawning as well as of clutch and egg size. We compare these results to other studies from the native and invaded range. In the Danube, the Round Goby population was found to be female dominated, however fluctuations in magnitude of female bias were observed between months. Monitoring of the population across 1.5 years revealed that GSI was highest from April to June, while lowest values were observed in August and September. Using time‐series analysis, a delayed effect of temperature on GSI was found for females and males, while a quicker response of GSI levels to photoperiod and discharge was observed for females. GSI increased with body size for females and eggs were found to be significantly larger in May, however clutch sizes did not differ between months. Results of a literature review revealed great differences in timing and length of spawning season as well as sex ratio between populations throughout the distribution range, which can probably be explained by climatic and photoperiodic conditions together with the time since invasion and the high plasticity of Round Gobies.
A global database of soil seed bank richness, density, and abundance
Authors: Auffret Alistair G. , Ladouceur Emma , Haussmann Natalie S. , Daouti Eirini , Elumeeva Tatiana G. , Kačergytė Ineta , Knape Jonas , Kotowska Dorota , Low Matthew , Onipchenko Vladimir G. , Paquet Matthieu , Rubene Diana , Plue Jan 
Published: October 2024

AbstractA soil seed bank is the collective name for viable seeds that are stored naturally in the soil. At the species or population level, the ability to form a seed bank represents a strategy for (re)colonization following a disturbance or other change in the local environmental conditions. At the community level, seed banks are thought to buffer local diversity during periods of environmental change and are often studied in relation to the potential for passive habitat restoration. The role that seed banks play in plant population and community dynamics, as well as their importance in the agricultural sector, means that they have been widely studied in ecological research. This database is the result of a comprehensive literature search, including all seed bank studies from the Web of Science from which data could be extracted, as well as an additional search of the Russian language literature. The database contains information on the species richness, seed density, and/or seed abundance in 3096 records from at least 1929 locations across the world's seven continents, extracted from 1442 studies published between 1940 and 2020. Records are grouped into five broad habitat categories (aquatic, arable, forest, grassland—including shrubland—and wetland), including information relating to habitat degradation from, or restoration to other habitats (total 14 combinations). Sampling protocols were also extracted for each record, and the database was extensively checked for errors. The location of each record was then used to extract summary climate data and biome classification from external published databases. The database has several potential uses. The large geographical spread relative to many other global biodiversity datasets is relevant for investigating patterns of diversity in biogeographical or macroecological contexts. Habitat type and status (intact, degraded, and restored) can be used to provide insights for biodiversity conservation, while the potential effects of sampling method and effort can be used to inform optimized data collection for future seed bank studies. This database is released under the CC‐BY license.
Treatment with brivaracetam has no apparent long‐term effects on body weight in pediatric patients with epilepsy
Authors: Floricel Florin I. , Reichel Paula E. , Dickson Najla , Fleyshman Sofia , Reichel Christoph , Elshoff Jan‐Peer 
Published: October 2024

AbstractObjectiveThe objective of this study is to evaluate possible long‐term effects of treatment with brivaracetam (BRV) on body weight in children with epilepsy.MethodPost hoc analysis of data from patients (aged 1 month to <17 years) with ≥6 months of BRV treatment in a long‐term, open‐label trial (N01266 [NCT01364597]). Outcomes included body weight and body mass index (BMI) over time (z‐score growth curves), and treatment‐emergent adverse events (TEAEs). Previous/ongoing medical conditions that may affect body weight (gastrointestinal and metabolic/nutritional disorders); concomitant antiseizure medications (ASMs) were also evaluated.ResultsTwo hundred nine patients (mean [standard deviation] age 7.9 [4.6] years) were analyzed. Most (154 [73.7%]) had focal‐onset seizures. At study initiation, median (range) BRV dose was 1.0 (0.4–7.5) mg/kg/day. Overall, 189 (90.4%) patients had a previous or ongoing medical condition (gastrointestinal disorders: 43 [20.6%]; metabolism/nutritional disorders: 26 [12.4%]). Most patients followed z‐score curves for body weight and BMI during BRV treatment, although there were outliers in both directions. Incidences of appetite/weight‐change TEAEs were low. Twenty‐three (11.0%) patients had a TEAE of decreased appetite and 14 (6.7%) had a TEAE of weight decreased.SignificanceLong‐term adjunctive BRV was well tolerated in growing children with no indication of detrimental effects on body weight.Plain Language SummaryBrivaracetam is an antiseizure medication (ASM) used to treat seizures in people with epilepsy. Some ASMs can lead to changes in people's appetite and weight. Knowing the effect a drug has on appetite and weight is particularly important in children. We looked at 209 children with epilepsy taking brivaracetam and studied changes in their body weight and body mass index over time. The number of reported side effects related to appetite or weight change was low. There was no apparent long‐term effect on their body weight, even when taking their medical history and use of other ASMs into account.