bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biased optimal guidance law with specified velocity rendezvous angle constraint
Authors: Xu X. , Liang Y. 
Published: February 2016

Abstract
In order to increase the effectiveness of interceptor missile, velocity rendezvous angle control is required in the terminal phase. The purpose of this paper is to obtain an optimal guidance law which can achieve specified velocity rendezvous angle as well as zero terminal miss distance. A biased optimal guidance law based on a simplified mathematical model is deduced for interceptors engaging against invasion aircraft. Different from previous literatures on this issue, the presented guidance law suitable for intercepting high-speed maneuvering target. Another advantage is, under centimeter level miss distance setting, the guidance law needs smaller guidance command near the terminal time, which can successfully avoid command saturation. Simulation results demonstrate the effectiveness of the presented guidance law.
Numerical investigation of symmetry breaking and multi-loop hysteresis phenomena in a symmetric supersonic combustor
Authors: Cui T. , Liu Z. 
Published: February 2016

AbstractNumerical investigations are performed to study the features of symmetry breaking phenomena in a symmetric supersonic combustor. By changing the fuel equivalence ratio, the symmetry breaking phenomena are numerically observed. Further, the hysteresis behaviours are observed along with the phenomena of symmetry breaking by increasing and then decreasing the the fuel equivalence ratio. Furthermore, more complex hysteresis phenomenon, i.e., multi-loop hysteresis, is observed numerically. The multi-loop hysteresis consists of both major and minor loops, and is associated with the interaction between multiple flow structures. Due to the fact that different flow structures would result in different flow conditions, the findings regarding the existence of hysteresis behaviours can significantly affect the combustion process and even the performance of the engine. It is hoped that the observation of the (multi-loop) hysteresis phenomenon may bring it to the attention of those investigators whose experiments maybe affected by its occurrence.
Consideration of structural constraints in passive rotor blade design for improved performance
Authors: Lim J. W. 
Published: February 2016

AbstractThis design study applied parameterisation to rotor blade for improved performance. In the design, parametric equations were used to represent blade planform changes over the existing rotor blade model. Design variables included blade twist, sweep, dihedral, and radial control point. Updates to the blade structural properties with changes in the design variables allowed accurate evaluation of performance objectives and realistic structural constraints – blade stability, steady moments (flap bending, chord bending, and torsion), and the high g manoeuvring pitch link loads. Performance improvement was demonstrated with multiple parametric designs. Using a parametric design with advanced aerofoils, the predicted power reduction was 1·0% in hover, 10·0% at μ = 0·30, and 17·0% at μ = 0·40 relative to the baseline UH-60A rotor, but these were obtained with a 35% increase in the steady chord bending moment at μ = 0·30 and a 20% increase in the half peak-to-peak pitch link load during the UH-60A UTTAS manoeuvre Low vibration was maintained for this design. More rigorous design efforts, such as chord tapering and/or structural redesign of the blade cross section, would enlarge the feasible design space and likely provide significant performance improvement.
Some Effects of Rice Quality on Rough Rice Prices
Authors: Brorsen B. Wade , Grant Warren R. , Rister M. Edward 
Published: February 2016

AbstractQuality discounts and premiums for rough rice in Texas rice bid/acceptance markets are analyzed. The most important quality factors determining the value of rough rice are head yield and peck. A one percentage point reduction in peck damage raises the price received per hundredweight of rough rice by $.13 to $.68 across markets and years. Since peck damage can be reduced by controlling the rice stinkbug, evaluation of alternative methods for better control of this pest in Texas rice fields is needed.
Differences in the quality of life of two groups of drug users
Authors: Rooney Siobhan , Freyne Aideen , Kelly Gabrielle , O'Connor John 
Published: February 2016

AbstractObjectives: The aim of this study was to compare aspects of the quality of life of drug users on a methadone maintenance programme to drug users on a harm minimisation programme.Method: Thirty-six clients attending the harm minimisation programme in the National Drug Treatment Centre, Dublin, were matched for age and sex to 36 clients on the methadone maintenance programme. All were interviewed with the SF-36 Health Survey Questionnaire to measure health related quality of life and with the Hospital Anxiety and Depression Scale (HADs) to measure psychological morbidity.Results: More clients from the harm minimisation programme had previous psychiatric problems than clients on the methadone maintenance programme, with an odds ratio of 4.3 CI(1.2,15.2). On the HADs, clients on the methadone maintenance programme had significantly lower depression scores than clients on the harm minimisation programme. In addition more clients on the harm minimisation programme were severely depressed than clients on the methadone maintenance programme. On the UK SF-36 Scale, clients on the harm minimisation programme perceived a significantly greater deterioration in ‘change in health’ over the previous year than clients on the methadone maintenance programme.Conclusions: Although clients on a methadone maintenance programme had an improved perception of their quality of life in relation to psychological and overall health function from the previous year, compared to clients on a harm minimisation programme, there still existed varying degrees of psychopathology in both groups which need to be considered when providing future services for drug users.
Whole genome sequencing reveals extensive community-level transmission of group AStreptococcusin remote communities
Authors: BOWEN A. C. , HARRIS T. , HOLT D. C. , GIFFARD P. M. , CARAPETIS J. R. , CAMPBELL P. T. , McVERNON J. , TONG S. Y. C. 
Published: February 2016

SUMMARYImpetigo is common in remote Indigenous children of northern Australia, with the primary driver in this context beingStreptococcus pyogenes[or group AStreptococcus(GAS)]. To reduce the high burden of impetigo, the transmission dynamics of GAS must be more clearly elucidated. We performed whole genome sequencing on 31 GAS isolates collected in a single community from children in 11 households with ⩾2 GAS-infected children. We aimed to determine whether transmission was occurring principally within households or across the community. The 31 isolates were represented by nine multilocus sequence types and isolates within each sequence type differed from one another by only 0–3 single nucleotide polymorphisms. There was evidence of extensive transmission both within households and across the community. Our findings suggest that strategies to reduce the burden of impetigo in this setting will need to extend beyond individual households, and incorporate multi-faceted, community-wide approaches.
Core Temperature Monitoring of Firefighters During Hazardous Materials Training Sessions
Authors: Menze Roger , McMullen Mary Jo , White Lynn J. , Dougherty James M. 
Published: February 2016

AbstractObjective:To determine core temperature (Tc) elevations in hazardous materials (HazMat) technicians wearing level-A fully encapsulated, chemically resistive suits (FECRSs) during training scenarios.Design:Cross-sectional, observational feasibility study with Institutional Review Board approval.Setting:HazMat training scenarios held during the summer of 1994. Weather conditions included both rainy and sunny days, with a mean ambient temperature of 75.8°F(24.3°C) (range 69–83° F [20.6–28.3°C).Participants:Nine male firefighters participating in training scenarios in the Midwestern United States.Interventions:Each volunteer swallowed a capsule containing a Tc sensor developed by the National Aeronautics and Space Administration. The capsule continuously monitored Tc and stored data in an ambulatory recorder worn under the level-A FECRS during training.Results:Mean age of the volunteers was 34 years, mean weight was 92.6 kg, and average baseline Tc was 36.7°C (97.1°F) (range 35.3–38.2°C [95.5–100°F]). Time in the FECRS averaged 25.4 minutes (range 14–35 minutes). All subjects demonstrated increased Tc while in the suit; the mean Tc increase was 0.8°C (1.4°F) (range 0.2–1.3°C [0.4–2.3°F]). The Tc continued to increase during wet decontamination procedures and after suit removal. Mean heat storage values (ΔTcx LBMx 3.47 kJ) were calculated, and found to be moderately elevated to 3.6 kJ/kg (range 2.1–4.6 kJ/kg).Conclusion:These observations support the validity and significance of implementing prophylactic measures for firefighters using protective clothing. Simple protective measures include enforced time limitations, hydration, and efforts to minimize heat buildup by avoiding both direct sunlight and unnecessary time encapsulated in the suit.
ON THE EXCEPTIONAL SPECIALIZATIONS OF BIG HEEGNER POINTS
Authors: Castella Francesc 
Published: February 2016

We extend the$p$-adic Gross–Zagier formula of Bertoliniet al.[Generalized Heegner cycles and$p$-adic Rankin$L$-series,Duke Math. J.162(6) (2013), 1033–1148] to the semistable non-crystalline setting, and combine it with our previous work [Castella, On the$p$-adic variation of Heegner points, Preprint, 2014,arXiv:1410.6591] to obtain a derivative formula for the specializations of Howard’s big Heegner points [Howard, Variation of Heegner points in Hida families,Invent. Math.167(1) (2007), 91–128] at exceptional primes in the Hida family.
Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa
Authors: Shinde V , Kotla P , Strang C , Gorbatyuk M 
Published: February 2016

AbstractThe molecular mechanism of autosomal dominant retinitis pigmentosa (ADRP) in rats is closely associated with a persistently activated unfolded protein response (UPR). If unchecked, the UPR might trigger apoptosis, leading to photoreceptor death. One of the UPR-activated cellular signaling culminating in apoptotic photoreceptor cell death is linked to an increase in intracellular Ca2+. Therefore, we validated whether ADRP retinas experience a cytosolic Ca2+ overload, and whether sustained UPR in the wild-type retina could promote retinal degeneration through Ca2+-mediated calpain activation. We performed an ex vivo experiment to measure intracellular Ca2+ in ADRP retinas as well as to detect the expression levels of proteins that act as Ca2+ sensors. In separate experiments with the subretinal injection of tunicamycin (UPR inducer) and a mixture of calcium ionophore (A231278) and thapsigargin (SERCA2b inhibitor) we assessed the consequences of a sustained UPR activation and increased intracellular Ca2+ in the wild-type retina, respectively, by performing scotopic ERG, histological, and western blot analyses. Results of the study revealed that induced UPR in the retina activates calpain-mediated signaling, and increased intracellular Ca2+ is capable of promoting retinal degeneration. A significant decline in ERG amplitudes at 6 weeks post treatment was associated with photoreceptor cell loss that occurred through calpain-activated CDK5-pJNK-Csp3/7 pathway. Similar calpain activation was found in ADRP rat retinas. A twofold increase in intracellular Ca2+ and up- and downregulations of ER membrane-associated Ca2+-regulated IP3R channels and SERCA2b transporters were detected. Therefore, sustained UPR activation in the ADRP rat retinas could promote retinal degeneration through increased intracellular Ca2+ and calpain-mediated apoptosis.
Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters
Authors: Crowell Samuel , Korniliev Pavel , Falcão Alexandre , Ismail Abdelbagi , Gregorio Glenn , Mezey Jason , McCouch Susan 
Published: February 2016

AbstractRice panicle architecture is a key target of selection when breeding for yield and grain quality. However, panicle phenotypes are difficult to measure and susceptible to confounding during genetic mapping due to correlation with flowering and subpopulation structure. Here we quantify 49 panicle phenotypes in 242 tropical rice accessions with the imaging platform PANorama. Using flowering as a covariate, we conduct a genome-wide association study (GWAS), detect numerous subpopulation-specific associations, and dissect multi-trait peaks using panicle phenotype covariates. Ten candidate genes in pathways known to regulate plant architecture fall under GWAS peaks, half of which overlap with quantitative trait loci identified in an experimental population. This is the first study to assess inflorescence phenotypes of field-grown material using a high-resolution phenotyping platform. Herein, we establish a panicle morphocline for domesticated rice, propose a genetic model underlying complex panicle traits, and demonstrate subtle links between panicle size and yield performance.
Probabilistic modelling of chromatin code landscape reveals functional diversity of enhancer-like chromatin states
Authors: Zhou Jian , Troyanskaya Olga G. 
Published: February 2016

AbstractInterpreting the functional state of chromatin from the combinatorial binding patterns of chromatin factors, that is, the chromatin codes, is crucial for decoding the epigenetic state of the cell. Here we present a systematic map of Drosophila chromatin states derived from data-driven probabilistic modelling of dependencies between chromatin factors. Our model not only recapitulates enhancer-like chromatin states as indicated by widely used enhancer marks but also divides these states into three functionally distinct groups, of which only one specific group possesses active enhancer activity. Moreover, we discover a strong association between one specific enhancer state and RNA Polymerase II pausing, linking transcription regulatory potential and chromatin organization. We also observe that with the exception of long-intron genes, chromatin state transition positions in transcriptionally active genes align with an absolute distance to their corresponding transcription start site, regardless of gene length. Using our method, we provide a resource that helps elucidate the functional and spatial organization of the chromatin code landscape.
Selective silicate-directed motility in diatoms
Authors: Bondoc Karen Grace V. , Heuschele Jan , Gillard Jeroen , Vyverman Wim , Pohnert Georg 
Published: February 2016

AbstractDiatoms are highly abundant unicellular algae that often dominate pelagic as well as benthic primary production in the oceans and inland waters. Being strictly dependent on silica to build their biomineralized cell walls, marine diatoms precipitate 240 × 1012 mol Si per year, which makes them the major sink in the global Si cycle. Dissolved silicic acid (dSi) availability frequently limits diatom productivity and influences species composition of communities. We show that benthic diatoms selectively perceive and behaviourally react to gradients of dSi. Cell speed increases under dSi-limited conditions in a chemokinetic response and, if gradients of this resource are present, increased directionality of cell movement promotes chemotaxis. The ability to exploit local and short-lived dSi hotspots using a specific search behaviour likely contributes to micro-scale patch dynamics in biofilm communities. On a global scale this behaviour might affect sediment–water dSi fluxes and biogeochemical cycling.
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
Authors: Husain Afzal , Begum Nasim A. , Taniguchi Takako , Taniguchi Hisaaki , Kobayashi Maki , Honjo Tasuku 
Published: February 2016

AbstractTopoisomerase 1, an enzyme that relieves superhelical tension, is implicated in transcription-associated mutagenesis and genome instability-associated with neurodegenerative diseases as well as activation-induced cytidine deaminase. From proteomic analysis of TOP1-associated proteins, we identify SMARCA4, an ATP-dependent chromatin remodeller; FACT, a histone chaperone; and H3K4me3, a transcriptionally active chromatin marker. Here we show that SMARCA4 knockdown in a B-cell line decreases TOP1 recruitment to chromatin, and leads to increases in Igh/c-Myc chromosomal translocations, variable and switch region mutations and negative superhelicity, all of which are also observed in response to TOP1 knockdown. In contrast, FACT knockdown inhibits association of TOP1 with H3K4me3, and severely reduces DNA cleavage and Igh/c-Myc translocations, without significant effect on TOP1 recruitment to chromatin. We thus propose that SMARCA4 is involved in the TOP1 recruitment to general chromatin, whereas FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage.
Elastic spheres can walk on water
Authors: Belden Jesse , Hurd Randy C. , Jandron Michael A. , Bower Allan F. , Truscott Tadd T. 
Published: February 2016

AbstractIncited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water impact physics. Here we show that upon water impact, very compliant spheres naturally assume a disk-like geometry and dynamic orientation that are favourable for water-skipping. Experiments and numerical modelling reveal that the initial spherical shape evolves as elastic waves propagate through the material. We find that the skipping dynamics are governed by the wave propagation speed and by the ratio of material shear modulus to hydrodynamic pressure. With these insights, we explain why softer spheres skip more easily than stiffer ones. Our results advance understanding of fluid-elastic body interaction during water impact, which could benefit inflatable craft modelling and, more playfully, design of elastic aquatic toys.
Realization of mid-infrared graphene hyperbolic metamaterials
Authors: Chang You-Chia , Liu Che-Hung , Liu Chang-Hua , Zhang Siyuan , Marder Seth R. , Narimanov Evgenii E. , Zhong Zhaohui , Norris Theodore B. 
Published: February 2016

AbstractWhile metal is the most common conducting constituent element in the fabrication of metamaterials, graphene provides another useful building block, that is, a truly two-dimensional conducting sheet whose conductivity can be controlled by doping. Here we report the experimental realization of a multilayer structure of alternating graphene and Al2O3 layers, a structure similar to the metal-dielectric multilayers commonly used in creating visible wavelength hyperbolic metamaterials. Chemical vapour deposited graphene rather than exfoliated or epitaxial graphene is used, because layer transfer methods are easily applied in fabrication. We employ a method of doping to increase the layer conductivity, and our analysis shows that the doped chemical vapour deposited graphene has good optical properties in the mid-infrared range. We therefore design the metamaterial for mid-infrared operation; our characterization with an infrared ellipsometer demonstrates that the metamaterial experiences an optical topological transition from elliptic to hyperbolic dispersion at a wavelength of 4.5 μm.
Graphene-Iodine Nanocomposites: Highly Potent Bacterial Inhibitors that are Bio-compatible with Human Cells
Authors: Some Surajit , Sohn Ji Soo , Kim Junmoo , Lee Su-Hyun , Lee Su Chan , Lee Jungpyo , Shackery Iman , Kim Sang Kyum , Kim So Hyun , Choi Nakwon , Cho Il-Joo , Jung Hyo-Il , Kang Shinill , Jun Seong Chan 
Published: February 2016

AbstractGraphene-composites, capable of inhibiting bacterial growth which is also bio-compatible with human cells have been highly sought after. Here we report for the first time the preparation of new graphene-iodine nano-composites via electrostatic interactions between positively charged graphene derivatives and triiodide anions. The resulting composites were characterized by X-ray photoemission spectroscopy, UV-spectroscopy, Raman spectroscopy and Scanning electron microscopy. The antibacterial potential of these graphene-iodine composites against Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirobilis, Staphylococcus aureus and E. coli was investigated. In addition, the cytotoxicity of the nanocomposite with human cells [human white blood cells (WBC), HeLa, MDA-MB-231, Fibroblast (primary human keratinocyte) and Keratinocyte (immortalized fibroblast)], was assessed. DGO (Double-oxidizes graphene oxide) was prepared by the additional oxidation of GO (graphene oxide). This generates more oxygen containing functional groups that can readily trap more H+, thus generating a positively charged surface area under highly acidic conditions. This step allowed bonding with a greater number of anionic triiodides and generated the most potent antibacterial agent among graphene-iodine and as-made povidone-iodine (PVP-I) composites also exhibited nontoxic to human cells culture. Thus, these nano-composites can be used to inhibit the growth of various bacterial species. Importantly, they are also very low-cytotoxic to human cells culture.
Inhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo-Indolin-3-ylidene] Amino] Thiourea(MBZM-N-IBT)
Authors: Mishra Priyadarsee , Kumar Abhishek , Mamidi Prabhudutta , Kumar Sameer , Basantray Itishree , Saswat Tanuja , Das Indrani , Nayak Tapas Kumar , Chattopadhyay Subhasis , Subudhi Bharat Bhusan , Chattopadhyay Soma 
Published: February 2016

AbstractChikungunya virus (CHIKV) infection is one of the most challenging human Arboviral infections with global significance and without any specific antiviral. In this investigation, 1-[(2-methylbenzimidazol-1-yl) methyl]-2-oxo-indolin-3-ylidene] amino] thiourea (MBZM-N-IBT) was synthesised as a molecular hybrid of 2-methyl benzimidazole and isatin-β-thiosemicarbazone and its anti-CHIKV property was evaluated. The release of infectious virus particles was calculated by plaque assay, expression profile of viral RNA was estimated by RT-PCR and viral protein profiles were assessed by Western blot and FACS analyses. The safety index of MBZM-N-IBT was found to be >21. The CHIKV infectious viral particle formation was abrogated around 76.02% by MBZM-N-IBT during infection in mammalian system and the viral RNA synthesis was reduced by 65.53% and 23.71% for nsP2 and E1 respectively. Surprisingly, the viral protein levels were reduced by 97% for both nsP2 and E2. In the time-of-addition experiment it abrogated viral infection at early as well as late phase of viral life cycle, which indicates about multiple mechanisms for its anti-CHIKV action.In silicoanalysis justified development of MBZM-N-IBT with good affinities for potential target proteins of CHIKV and related virus. With predictions of good drug-likeness property, it shows potential of a drug candidate which needs further experimental validation.