bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amisulpride - An Athypical Antipsychotic?
Authors: George Echim , Cucuiet Sorina , Osz Bianca , Grosan Alexandra , Zsolt Gal , Dogaru Maria 
Published: January 2016

Abstract

Aim: the purpose of the present study was to determine the effects of amisulpride at different doses on body weight, glucidic and lipidic metabolism.

Material and method: Thirty-six white Wistar rats were treated daily for 9 weeks with amisulpride 1mg/kg and 10mg/kg body weight. Another group received distilled water and served as control group. At the end of the treatment period blood samples were collected and the follow biochemical parameters were determined: serum cholesterol, triglycerides, blood glucose, GOT, GPT. Body weight gain was also assessed weekly.

Results: After treatment with amisulpride in doses of 1mg/kg and 10 mg/kg for a period of nine weeks, weight gains were recorded for both groups compared with the initial weight and the control group. Blood glucose concentrations in the group treated with 1 mg amisulpride/kg body weight were significantly increased (p<0.05 vs control group), but in the group treated with 10 mg/kg body weight glucose levels were not statistically significant increased compared to controls. Other biochemical parameters (cholesterol, triglycerides, GOT, GPT) showed no statistically significant differences compared to control group.

Conclusions: amisulpride administered over a period of 9 weeks, in doses of 1mg/kg and 10mg/kg showed a slight increase of body weight regardless of gender, increased blood glucose only when was administered in the low dose, and does not affect lipid metabolism, even though decreased cholesterol and triglycerides levels. This results highlight a real benefit of treatment with amisulpride, comparatively with other athypical antipsychotics.
The Monitoring of Immunosuppressive Therapy with Tacrolimus in Patients with Kidney Transplant, Based on the Pharmacokinetic Criteria
Authors: Mihai Stoica Ciprian , Denise Căldăraru Carmen , Eugen Vari Camil , Ionuţ Tarţa Dorin , Titica Dogaru Maria , Emilian Caraşca , Aloiziu Dogaru Grigore 
Published: January 2016

Abstract

Background: Therapeutic drug monitoring (TDM) in patients with Chronic Kidney Disease (CKD) with kidney transplant, represents a major post transplant concern due to the characteristics of this special category of patients, particularities which can generate changes of the pharmacokinetic profile of the administered medication.

Material and methods: The current study is a retrospective pharmacokinetic study, over a period of 50 months, including a group of 36 kidney transplanted patients with CKD. Tacrolimus blood concentration was determined by a validated high-performance liquid chromatography method (HPLC), at a 12 hour time interval from the last administration of the immunosuppressive medication and before the following dose (Residual concentration, Cmin(trough)).

Results: During the monitoring of therapy, based on the pharmacokinetic criteria, 252 measurements of blood concentration were determined, 58 of these being outside the therapeutic window.

Conclusions: The results obtained show that it is mandatory to continue to monitor closely medical therapy based on the pharmacokinetic criteria in view of improving drug administration. The other ways of monitoring therapy: the clinical and biochemical criteria should not be overlooked. In addition, the interindividual variability of patients should be considered, as well as drug interaction which can alter the pharmacokinetics of tacrolimus.
Surgical Management of Renal Hyperparathyroidism: Case Series and Review of the Literature
Authors: Mircea Neagoe Radu , Mircea Mureşan , Smaranda Văcar , Ioan Hossu , Ionela Paşcanu , Angela Borda , Daniela Sala 
Published: January 2016

Abstract
Secondary hyperparathyroidism (sHPT) occurs most commonly in the setting of chronic renal failure (CRF) being frequently referred to as “renal” hyperparathyroidism The “classical” medical treatment with oral calcium and vitamin D supplementation is generally sufficient to lower parathyroid hormone levels in the majority of these patients. However, we frequently encounter cases of severe refractory sHPT, a state in which even recently available therapeutic agents, i.e. calcimimetics, new phosphate binders, vitamin D analogues, remain inefficient, thus parathyroidectomy and/or renal transplant becoming necessary. Three types of surgeries have been proposed in sHPT: two of them are grouped as remnant-conserving techniques, i.e. subtotal parathyroidectomy (sPtx) and total parathyroidectomy with autotransplantation (tPtx+AT), the third one being total parathyroidectomy without autotransplantation (tPtx). There was a continuous debate concerning the best surgical approach in renal hyperparathyroidism, starting very soon after those techniques were described; without pretending to solve these controversies, this paper aims to review the surgical treatment options in sHPT, based on our 5-year experience in dealing with the disease.
The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats
Authors: Bianca-Liana Grigorescu , Ştefania Fodor Raluca , Alina Scridon , Marcel Perian , Iudita Badea , Adrian Dan Cioc , Simion Cotoi Ovidiu , Sanda-Maria Copotoiu , Leonard Azamfirei 
Published: January 2016

Abstract

Objective: The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the hind limbs in healthy versus diabetic ischemic preconditioned rats.

Method: The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic preconditioned group. Acute ischemia was induced, followed by reperfusion. The assessment of reperfusion injury used biochemical, histopathological and functional determinations (peak tetanic tension-PTT, specific tension-ST).

Results: Ischemia-reperfusion injury was more severe in control group regarding creatine-kinase (CK) (CK1=470.13 IU/L versus CK2=230.88 IU/L, p=0.0001) and myoglobin (390.25 ng/mL versus 47.99 ng/mL, p=0.025). Cytolysis enzymes were significantly increased in diabetic preconditioned rats (Alanine aminotransferase ALAT1=46 IU/L, ALAT2=167.8 IU/L, p=0.02; Aspartate aminotransferase ASAT1=106 IU/L, ASAT2=237.5 IU/L, p=0.016). Functional assessment (PTT and ST) highlighted roughly equal values. A paradoxical response occurred in diabetic rats (the contractile force increased during the period of the stimulation). Histopathological findings showed that rhabdomyolysis was more severe in the control group, while inflammatory systemic response due to reperfusion injury was less expressed in diabetic ischemic preconditioned rats.

Conclusions: Ischemic preconditioning reduces the severity of reperfusion injury and allows the preservation of contractile muscle function in diabetic rats.
Ambulatory Blood Pressure and Arterial Stiffness in Obese Children and Adolescents
Authors: Carmen Duicu , Oana Mărginean Cristina , Maria Pitea Ana , Elena Melit Lorena 
Published: January 2016

Abstract
The aim of the present study was to investigate differences regarding 24-hour blood pressure and arterial stiffness in a cohort of office normotensive obese and non-obese children and adolescents, and to evaluate correlations of these parameters with some anthropometric indices. We retrospectively evaluated ABPM records in 71 children (42 boys); 31 obese compared with 40 normal-weight children.

Results: Mean 24-hour, day-time and night-time SBP was significantly higher in the obese group than in the control group (p <0.01 during the entire period). Significantly higher AASI values were found in obese children compared to controls (0.45 vs. 0.41, p <0.05), the difference being more obvious for day-time AASI (p <0.001).

Conclusions: This research confirms that SBP and AASI are increased in obese children. AASI is a useful index of arterial stiffness that can be easily measured under ambulatory circumstances in children.
The Prevalence and Distribution of High Risk Human Papillomavirus Genotypes in Patients with Dysplastic Lesions: a Population Study
Authors: Septimiu Voidăzan , Silviu-Horia Morariu , Mihai Căpâlnă , Claudiu Mărginean , Minodora Dobreanu 
Published: January 2016

Abstract

Background. Cervical cancer (CC) is a major public health problem worldwide. Knowledge of human papillomavirus (HPV) genotype prevalence and distribution is important for the introduction of an effective vaccination program and the corresponding epidemiological monitoring. The aim of this study was to identify and analyze the distribution of high-risk HPV genotypes.

Methods. Data were collected from 136 patients for the detection of circulating HPV genotypes, where Pap test results revealed the presence of koilocytes or high risk (HR) dysplastic lesions, elements that raise the suspicion of HPV infection.

Results. HPV infection was identified in 72 (55.4%) of the patients tested, 34 (47.3%) with single infection, and 38 (52.7%) with multiple infections. Twenty-two different types of HPV were identified: 14 high risk HPV types, 7 low risk HPV types, 1 probable high risk HPV type. HPV 16 was the most frequently detected (55.6%) one, it was involved in single (15 cases) and multiple (25 cases) infections, primarily associated with type 18 (12 cases), and type 52 (11 cases). The presence of HPV 18 (29.2%) and HPV 52 (23.6%) was identified after HPV type 16.

Conclusions. Oncogenic HPV genotypes 16, 18, and 52 were most frequently associated in women with dysplastic lesions, which require the use of polyvalent HPV vaccines when assessing cross-protective effects of specific immunoprophylaxis programs.
The Role of Urodynamic Investigations in Management of Stress Urinary Incontinence
Authors: Ghirca Veronica Maria , Porav-Hodade D , Chibelean C , Voidazan S , Vartolomei M , Boja R , Martha Orsolya 
Published: January 2016

Abstract

Objective: The aim of this study is to establish the importance of urodynamic investigations in women diagnosed with stress urinary incontinence (SUI) who have indication of surgical treatment.

Methods: We performed a retrospective study over a period of 3 years (January 2012-December 2014) in Clinic of Urology from Tirgu Mures. The inclusion criteria were: female patients diagnosed with SUI having indication of surgical treatment and the existence of urodynamic investigations (uroflowmetry and pressure-flow study). We evaluated 118 patients with SUI. From this patients, 24 cases (20.3%) accomplished the criteria from above.

Results: We included in this study 24 patients aged 64.25+/−8.25 (standard deviation). Pressure-flow study revealed an impaired detrusor contraction in 13 cases. Statistical anaysis pouved a relation between existence of post void residual urine (PVR) and underactive detrusor (UD) (p=0.01). There is no correlation between maximum flow rate (Qmax) and UD, r=0.18 (CI= −0.2-0.5), p=0.3 and between normal value of Qmax and normal detrusor pressure (Pdet), r= 0,28(CI=−0.6-0.8), p=0.58. Also there is no relation between a low Qmax and UD, p=0,5. There is a statistical relation between increased abdominal pressure (Pabd) and UD, p=0.02.

Conclusions: Uroflowmetry has the role to guide us concerning the micturition process Pressure-flow study is indicated in management of SUI, in selected cases, in patients with voiding symptomatology, the suspicion of a detrusor contractility dysfunction, abnormal uroflowmetry results, existence of PVR, in prediction of the surgical treatment outcome or if we think that the findings can change the choice of treatment.
Ein einfacher Zustandsreglerentwurf im Zuge der Erweiterung der Systemstruktur um Reglerintegratoren und Rechentotzeiten
Authors: Nuß Uwe 
Published: January 2016

Zusammenfassung
Im vorliegenden Beitrag wird beschrieben, wie bereits entworfene Zustandsregler für proportional geregelte Systeme ohne Rechentotzeit auf einfache Art und Weise für Systeme mit Reglerintegratoren bzw. mit Rechentotzeit erweitert werden können. Das Ziel ist hierbei, den Aufwand zur Ermittlung der Reglermatrix zu reduzieren. Hierbei soll die bereits vorhandene, optimierte Regelkreisdynamik so wenig wie möglich verändert werden, wodurch bei Mehrgrößensystemen hinzukommende Freiheitsgrade sinnvoll festgelegt werden. Die Betrachtungen erfolgen für lineare zeitdiskrete Systeme und werden anhand eines Beispiels aus der elektrischen Antriebstechnik veranschaulicht.
Multiple Human Biometrics Fusion in Support of Cyberthreats Identification
Authors: Minchev Zlatogor 
Published: January 2016

Abstract
The paper is outlining an experimentally created framework for multiple human biometrics fusion in support to constantly evolving complex cyberthreats landscape identification. A “scenario method” approach, in combination with experts’ based decision support and users’ biometric “validation-in-advance”, are considered. Practical examples are also given to the proposed ideas, providing a comprehensive outlook to the problem.
The Impact of the Quality Assessment of Optimal Assignment for Data Association in a Multitarget Tracking Context
Authors: Dezert J. , Tchamova A. , Konstantinova P. 
Published: January 2016

Abstract
The main purpose of this paper is to apply and to test the performance of a new method, based on belief functions, proposed by Dezert et al. in order to evaluate the quality of the individual association pairings provided in the optimal data association solution for improving the performances of multisensor-multitarget tracking systems. The advantages of its implementation in an illustrative realistic surveillance context, when some of the association decisions are unreliable and doubtful and lead to potentially critical mistake, are discussed. A comparison with the results obtained on the base of Generalized Data Association is made.
Cloud Based Patient Monitoring Platform Using Android Smartphone Sensors
Authors: Nikolovski Vlatko , Lameski Petre , Chorbev Ivan 
Published: January 2016

Abstract
This paper presents a proof of the concept cloud based patient monitoring and self-care platform, powered by measurements provided from various smartphone sensors. The Cloud platform provides the infrastructure and computational capacity for calculation of the navigation and motion tracking system, fall detection monitoring, as well as emergency notifications. The navigation system uses the pedometer and fusion of the accelerometer, gyroscope and magnetometer sensors. It aims to estimate precisely the patient’s movement and location. While both navigation and tracking systems can independently determine the incremental movement and indoor localization of the patients, they are fused in order to provide more accurate estimations. The fall detection monitoring is enabled by processing the raw data collected from the smartphone’s accelerometer and gyroscope. Furthermore, the cloud system provides various statistics for the physical activity of the patients, based on measurements from the pedometer. Consequently, this paper proposes a proof of the concept cloud based platform that is scalable and highly responsive, used for real-time monitoring and tracking a large number of patients. It also provides indoor navigation and other self-care features.
On (n+1)-Hom-Lie algebras induced by n-Hom-Lie algebras
Authors: Kitouni Abdennour , Makhlouf Abdenacer , Silvestrov Sergei 
Published: January 2016

Abstract
The purpose of this paper is to study the relationships between an n-Hom-Lie algebra and its induced (n+1)-Hom-Lie algebra. We provide an overview of the theory and explore structure properties such as ideals, centers, derived series, solvability, nilpotency, central extensions, and the cohomology.
Manganese Oxides in Heterogeneous (Photo)Catalysis: Possibilities and Challenges
Authors: Ristig Simon , Cibura Niklas , Strunk Jennifer 
Published: January 2016

Abstract
The aim to develop active photocatalysts based on abundant elements for solar energy conversion reactions has sparked wide interest in manganese oxides as visible light-absorbing alternative to TiO2. Today, a multitude of different routes are available for the synthesis of MnO
x
species with specific stoichiometry, crystal structure, morphology, size or surface properties. Still, even for the bulk manganese oxides, some controversy remains, for example, with respect to the band gap, which hinders the targeted development of specific manganese oxide catalysts for photocatalysis. In classical heterogeneous catalysis and electrocatalysis, manganese oxides have been successfully used for a wide range of reactions, in particular in the field of (selective) oxidations. Photocatalytic applications have also been reported, but a true photocatalyst for the famous water-splitting reaction, deep insight into the prevailing mechanisms and an understanding of the involved processes has yet to be found. With this review, we aim to give a comprehensive overview over the structural, physical and catalytic properties of manganese oxides, together with an overview over suitable synthesis procedures. This will then serve as a basis for the discussion of the state of the art in the application of manganese oxides in catalysis and photocatalysis.
MAXNET Energy – Focusing Research in Chemical Energy Conversion on the Electrocatlytic Oxygen Evolution
Authors: Auer Alexander A. , Cap Sébastien , Antonietti Markus , Cherevko Serhiy , Deng Xiaohui , Papakonstantinou Georgios , Sundmacher Kai , Brüller Sebastian , Antonyshyn Iryna , Dimitratos Nikolaos , Davis Robert J. , Böhm Karl-Heinz , Fechler Nina , Freakley Simon , Grin Yuri , Gunnoe Brent T. , Haj-Hariri Hossein , Hutchings Graham , Liang Haiwei , Mayrhofer Karl J. J. , Müllen Klaus , Neese Frank , Ranjan Chinmoy , Sankar Meenakshisundaram , Schlögl Robert , Schüth Ferdi , Spanos Ioannis , Stratmann Martin , Tüysüz Harun , Vidakovic-Koch Tanja , Yi Youngmi , Zangari Giovanni 
Published: January 2016

Abstract
MAXNET Energy is an initiative of the Max Planck society in which eight Max Planck institutes and two external partner institutions form a research consortium aiming at a deeper understanding of the electrocatalytic conversion of small molecules. We give an overview of the activities within the MAXNET Energy research consortium. The main focus of research is the electrocatalytic water splitting reaction with an emphasis on the anodic oxygen evolution reaction (OER). Activities span a broad range from creation of novel catalysts by means of chemical or material synthesis, characterization and analysis applying innovative electrochemical techniques, atomistic simulations of state-of-the-art x-ray spectroscopy up to model-based systems analysis of coupled reaction and transport mechanisms. Synergy between the partners in the consortium is generated by two modes of cooperation – one in which instrumentation, techniques and expertise are shared, and one in which common standard materials and test protocols are used jointly for optimal comparability of results and to direct further development. We outline the special structure of the research consortium, give an overview of its members and their expertise and review recent scientific achievements in materials science as well as chemical and physical analysis and techniques. Due to the extreme conditions a catalyst has to endure in the OER, a central requirement for a good oxygen evolution catalyst is not only its activity, but even more so its high stability. Hence, besides detailed degradation studies, a central feature of MAXNET Energy is a standardized test setup/protocol for catalyst stability, which we propose in this contribution.
The role of silicon (Si) in increasing plant resistance against fungal diseases
Authors: Sakr N. 
Published: January 2016

Summary
The use of silicon (Si) in agriculture has attracted a great deal of interest from researchers because of the numerous benefits of this element to plants. The use of silicon has decreased the intensity of several diseases in crops of great economic importance. In this study, the relationship between silicon nutrition and fungal disease development in plants was reviewed. The current review underlines the agricultural importance of silicon in crops, the potential for controlling fungal plant pathogens by silicon treatment, the different mechanisms of silicon-enhanced resistance, and the inhibitory effects of silicon on plant pathogenic fungi in vitro. By combining the data presented in this paper, a better comprehension of the relationship between silicon treatments, increasing plant resistance, and decreasing severity of fungal diseases could be achieved.
Swarming motility in plant-associated bacteria
Authors: Venieraki A. , Tsalgatidou P.Ch. , Georgakopoulos D.G. , Dimou M. , Katinakis P. 
Published: January 2016

Summary
Plant-associated environments harbor a huge number of diverse bacteria that compete and/or cooperate for the occupation of the most nutrient-rich ecological niches. Motility, a common trait among bacteria, has long been assumed to provide a survival advantage to skilful bacteria in invading these environments. Bacterial surface motility, such as swarming, a flagella-driven type of surface movement, although mostly observed and studied on agar substrates, is emerging as a major trait involved in many functions of plant-associated bacteria in regard to their ability to colonize and spread on their host. In this review, we address some novel swarming motility strategies, which enable bacteria to colonize, disperse and compete in plant surfaces.
Effectiveness of salicylic acid, Pseudomonas fluorescens CHA0 and Trichoderma viride to control Meloidogyne incognita race 2 on different tomato cultivars
Authors: Esfahani L. , Jamali S. , Saeedizadeh A. , Pedramfar H. 
Published: January 2016

Summary
The effects of salicylic acid (SA), Trichoderma viride and Pseudomonas fluorescens CHA0 were studied on the root-knot nematode Meloidogyne incognita race 2 in resistant and susceptible tomato cultivars (Gina VF, Falat CH, Falat 111, Karoon) during 2012-2013. Four-leaf tomato seedlings were used, grown in pots containing 1000 g of sterilized soil; each seedling receiving 20 ml of T. viride suspension containing 1×106 spores, 30 ml of P. fluorescens CHA0 with 109 cfu/ml, 5mM of salicylic acid and 2000 second stage nematode juveniles. Parameters relevant to nematode population and plant growth were evaluated. The biocontrol agents and salicylic acid were effective in nematode control in combined and single treatments. High reductions in root galling and egg mass indices were observed with combination of SA and biocontrol agents. The greatest increase in plant growth was obtained when cv. Falat CH was treated with SA followed by P. fluorescens CHA0 and T. viride. The highest number of galls was recorded in cv. Karoon, followed by cvs. Falat 111, Gina VF and Falat CH. Pseudomonas fluorescens CHA0 provoked the highest increase in fresh and dry root weight, fresh and dry shoot weight and plant length in all free nematode treatments. The results indicated that chemical inducer (salicylic acid), in combination with biocontrol agents (T. viride and P. fluorescens CHA0), stimulated and eventually increased plant growth.
First report of the nematodes Filenchus orientalis and Hemicriconemoides californianus on faba bean in Iran
Authors: Azimi S. , Mahdikhani-Moghadam E. , Rouhani H. , Rajabi Memari H. 
Published: January 2016

Summary
During a survey in Iran, two known species of plant-parasitic nematodes of the families Tylenchidae and Criconematidae were reported for the first time. The morphological and morphometric characters of Iranian populations of the two recovered species are discussed and illustrated based on morphological and morphometrics data. Iranian population of Filenchus orientalis is characterized by having a 601-755μm body length, stylet length of 9.0-11.3 μm, lateral field with four incisures, tail length of 100-118 μm and males with 15-21 μm long spicules. Hemicriconemoides californianus population is characterized by having a body length of 430-550μm, lip region with two annuli, stylet length of 75-83μm and tail length of 20-28 μm. The morphological and morphometric characters of both species are in agreement with those in original descriptions.