bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Border Evidence Gathering in Transnational Criminal Investigation: Is the Microsoft Ireland Case the “Next Frontier”?
Authors: CURRIE ROBERT J. 
Published: August 2017

AbstractA recent and prominent American appeals court case has revived a controversial international law question: can a state compel a person on its territory to obtain and produce material that the person owns or controls, but which is stored on the territory of a foreign state? The case involved, United States v Microsoft, features electronic data stored offshore that was sought in the context of a criminal prosecution. It highlights the current legal complexity surrounding the cross-border gathering of electronic evidence, which has produced friction and divergent state practice. The author here contends that the problems involved are best understood — and potentially resolved — via an examination through the lens of the public international law of jurisdiction and, specifically, the prohibition of extraterritorial enforcement jurisdiction. An analysis of state practice reveals that unsanctioned cross-border evidence gathering is viewed by states as an intrusion on territorial sovereignty, engaging the prohibition, and that this view properly extends to the kind of state activity dealt with in the Microsoft Ireland case.
Boardthink: Exploring the discourses and mind-sets of directors
Authors: Carroll Brigid , Ingley Coral , Inkson Kerr 
Published: August 2017

AbstractIn a context of institutionalized regulation and academic framing determined by agency theory, we note paradoxes in board governance literature and practice. These paradoxes concern boards’ conflicting roles of monitoring/control, and innovation/strategy-making. We explore directors’ mind-sets about governance on which their resolution of paradoxes and their decisions and actions will be based. We do this by applying discourse analysis to the transcripts of 60 semistructured interviews conducted with New Zealand directors who described and evaluated their experience of board governance. We identify and discuss their various discourses, which we label discourses of conformance, of deliberation, of enterprise and of bounded innovation. We note the homogeneity of discourses across different organization types, the dominance of conformance, the nonresolution of paradoxes, and the likely effects in inhibiting board strategy-making and contribution to innovation. We recommend attention by boards to their mind-sets and processes, and the development of generativity.
Khwaja sara, hijra, and the Struggle for Rights in Pakistan
Authors: KHAN SHAHNAZ 
Published: August 2017

AbstractDrawing upon interviews with individuals in Pakistan who cannot be identified as heterosexual or be contained by the gender binary, I argue that in recent years post-colonial legacies of colonial laws have been challenged in Pakistan in ways that suggest a complicated relationship among sexuality, gender, and modernity. I draw upon Partha Chatterjee's notion of political society to situate this relationship. As such, I seek to strengthen prior discussions located in India and Pakistan. Further, this article challenges the problematic assumptions in mainstream queer politics that Muslim societies are static and ahistorical assumptions that appear to assume progress and struggle for sexual rights to be a Western attribute. In so doing, I extend earlier critiques arguing for a more complex understanding of the rule of non-normative sexualities in Muslim societies and suggest that colonial policies that regulated and criminalized the more fluid forms of sexuality in Muslim societies were incorporated in the imperial project of civilizing non-European cultures. The stability of colonial policies regarding sexuality was challenged in 2009 when the Pakistani state gave political recognition to trans* communities, identifying them as citizens of a modern state. These changes, I argue, pave the way for a potential shift from the fluid sexuality and irreverence that khwaja sara are usually associated with middle-class norms of respectability and encouragement towards assimilation into the social order.
Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art
Authors: CHARLTON REBECCA L. , ROSSI-BERGMANN BARTIRA , DENNY PAUL W. , STEEL PATRICK G. 
Published: August 2017

SUMMARYLeishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genusLeishmaniafor which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-economic hardship, best measured in 2·4 million disability adjusted life years, with greatest impact on the poorest communities, which means that desperately needed new antileishmanial treatments have to be both affordable and accessible. Established medicines with cheaper and faster development times may hold the cure for this neglected tropical disease. This concept of using old drugs for new diseases may not be novel but, with the ambitious target of controlling or eradicating tropical diseases by 2020, this strategy is still an important one. In this review, we will explore the current state-of-the-art of drug repurposing strategies in the search for new treatments for leishmaniasis.
Larval development of Angiostrongylus chabaudi, the causative agent of feline angiostrongylosis, in the snail Cornu aspersum
Authors: COLELLA V. , CAVALERA M. A. , DEAK G. , TARALLO V. D. , GHERMAN C. M. , MIHALCA A. D. , OTRANTO D. 
Published: August 2017

SUMMARYNematodes of the Angiostrongylidae family, such as Angiostrongylus vasorum and Angiostrongylus cantonensis, may cause potentially life-threatening diseases in several mammal species. Alongside these well-known species, Angiostrongylus chabaudi has been recently found affecting the cardiopulmonary system of domestic and wild cats from Italy, Germany, Greece, Romania and Bulgaria. Nonetheless, significant gaps in the understanding of A. chabaudi epidemiology include the lack of information of species acting as intermediate host and of the morphological description of larval stages. Cornu aspersum (n = 30) land snails were infected with 100 first-stage larvae of A. chabaudi collected from a naturally infected wildcat in Romania. Larvae at different developmental stages were found in 29 out of 30 (96·7%) infected snails and a total of 282 (mean 9·8 ± 3·02 larvae per each specimen) were collected from the gastropods. Here we demonstrate that A. chabaudi develops in snails and report C. aspersum as potential intermediate host for this parasitic nematode. Findings of this study are central to understand the ecological features of feline angiostrongylosis and its epidemiology within paratenic and intermediate hosts.
The in vitro anthelmintic activity of the ethanol leaf extracts of Terminalia catappa L. on Fasciola gigantica
Authors: ANURACPREEDA PANAT , CHAWENGKIRTTIKUL RUNGLAWAN , NGAMNIYOM ARIN , PANYARACHUN BUSABA , PUTTARAK PANUPONG , KOEDRITH PREEYAPORN , INTARATAT NOPPADOL 
Published: August 2017

SUMMARYAt present, there are no medicinal plant extracts currently available for treatment and control of fasciolosis. The present work could provide, for the first study, conclusions on the in vitro fasciolicidal properties of the ethanol extract of Terminalia catappa L. (TcCE) leaves against adult Fasciola gigantica after incubation with RPMI-1640 medium containing the TcCE at various concentrations and times when compared with triclabendazole (TCZ). The relative motility and survival index values of the TcCE-treated flukes decreased at a more rapid rate than the TCZ-treated flukes. The death of the parasites was observed after exposed to TcCE at 3 h incubation with 400, 800 and 1000 µg mL−1, and at 6 h incubation in 100 and 200 µg mL−1. Vacuolization, blebbings and partial disruption on the parasites’ tegument were observed by light microscopy. When examined by scanning electron microscopy, TcCE caused similar tegumental alterations in the parasites as those observed in TCZ treatment but with larger damage at comparative incubation periods, consisting of swelling, blebbing, disrupted blebs, loss of spines, leading to the erosion, lesion and eventual disruption of the total tegument. Therefore, the TcCE may exert its fasciolicidal effect against F. gigantica by initially causing the tegumental alteration.
Buffering effects of safe, supportive, and nurturing relationships among women with childhood histories of maltreatment
Authors: Jaffee S. R , Takizawa R. , Arseneault L. 
Published: August 2017

BackgroundAdults who were victims of childhood maltreatment tend to have poorer health compared with adults who did not experience abuse. However, many are in good health. We tested whether safe, supportive, and nurturing relationships buffer women with a history of childhood maltreatment from poor health outcomes in later life.MethodsParticipants included women from the Environmental Risk (E-Risk) Longitudinal Twin Study who were involved in an intimate relationship at some point by the time their twin children were 10 years old. Women were initially interviewed in 1999–2000 (mean age = 33 years) and 2, 5, and 7 years later. They reported on their physical and mental health, and their health-risk behaviours.ResultsCompared with women who did not experience abuse in childhood, women with histories of maltreatment were at elevated risk for mental, physical, and health-risk behaviours, including major depressive disorder, sleep, and substance use problems. Cumulatively, safe, supportive, and nurturing relationships characterized by a lack of violence, emotional intimacy, and social support buffered women with a history of maltreatment from poor health outcomes.ConclusionsOur findings emphasize that negative social determinants of health – such as a childhood history of maltreatment – confer risk for psychopathology and other physical health problems. If, however, a woman's current social circumstances are sufficiently positive, they can promote good health, particularly in the face of past adversity.
Latent traits of impulsivity and compulsivity: toward dimensional psychiatry
Authors: Chamberlain S. R. , Stochl J. , Redden S. A. , Grant J. E. 
Published: August 2017

BackgroundThe concepts of impulsivity and compulsivity are commonly used in psychiatry. Little is known about whether different manifest measures of impulsivity and compulsivity (behavior, personality, and cognition) map onto underlying latent traits; and if so, their inter-relationship.MethodsA total of 576 adults were recruited using media advertisements. Psychopathological, personality, and cognitive measures of impulsivity and compulsivity were completed. Confirmatory factor analysis was used to identify the optimal model.ResultsThe data were best explained by a two-factor model, corresponding to latent traits of impulsivity and compulsivity, respectively, which were positively correlated with each other. This model was statistically superior to the alternative models of their being one underlying factor (‘disinhibition’) or two anticorrelated factors. Higher scores on the impulsive and compulsive latent factors were each significantly associated with worse quality of life (both p < 0.0001).ConclusionsThis study supports the existence of latent functionally impairing dimensional forms of impulsivity and compulsivity, which are positively correlated. Future work should examine the neurobiological and neurochemical underpinnings of these latent traits; and explore whether they can be used as candidate treatment targets. The findings have implications for diagnostic classification systems, suggesting that combining categorical and dimensional approaches may be valuable and clinically relevant.
Hybrid ant colony optimization for capacitated multiple-allocation cluster hub location problem
Authors: Mirabi Mohammad , Seddighi Parya 
Published: August 2017

AbstractThe hub location problems involve locating facilities and designing hub networks to minimize the total cost of transportation (as a function of distance) between hubs, establishing facilities and demand management. In this paper, we consider the capacitated cluster hub location problem because of its wide range of applications in real-world cases, especially in transportation and telecommunication networks. In this regard, a mathematical model is presented to address this problem under capacity constraints imposed on hubs and transportation lines. Then, a new hybrid algorithm based on simulated annealing and ant colony optimization is proposed to solve the presented problem. Finally, the computational experiments demonstrate that the proposed heuristic algorithm is both effective and efficient.
Elliptic Fourier analysis and perceptual matching for the evaluation of bioinspired sketching in conceptual design
Authors: Yang Zhongliang , Chen Yumiao , Liu Zheng 
Published: August 2017

AbstractBiologically inspired design can be used to aid in conceptual design. Sketching is an important ideation process in conceptual design for recording and evaluating flashing moments of inspiration. The present study aims to provide a framework for exploring the effects of biological examples on the sketching contours of products, as well as the perceptual matching degree between design ideas generated via sketching and the desired functions. Elliptic Fourier descriptors with principal component analysis and perceptual matching were used to evaluate and compare the effects of biological examples, no examples, and human-engineered examples from different product categories and within one product category on the sketches in an experiment that involved 28 participants. The application of elliptic Fourier descriptors with principal component analysis shows that there are significant differences in the third and seventh principal components. It is also found that exposure to biological examples can produce more sketches with high perceptual matching degree than the other three conditions, but there are no significant effects of the example exposure on the Pearson correlation coefficients of semantic differential evaluation value vectors between design problems and sketches. These results demonstrate that exposure to biological examples will correlate with Elliptic Fourier descriptors of sketches and will not significantly increase the perceptual matching degree between sketches and the desired function.
Estimating the risk of invasive group A Streptococcus infection in care home residents in England, 2009–2010
Authors: SAAVEDRA-CAMPOS M. , SIMONE B. , BALASEGARAM S. , WRIGHT A. , USDIN M. , LAMAGNI T. 
Published: August 2017

SUMMARYInvasive group A streptococcal (iGAS) infections cause severe disease and death, especially in residents of long-term care facilities (LTCFs). In order to inform iGAS prevention, we compared the risk of iGAS in LTCF residents and community residents. We identified LTCF residents among cases of iGAS from national surveillance (2009–2010) using postcode matching, and cases of hospital-acquired infections via hospital admission records. We used Poisson regression to calculate incidence rate ratios (IRR) and logistic regression to explore factors associated with case fatality rate (CFR). A total of 2741 laboratory-confirmed iGAS cases were matched to a hospital admission: 156 (6%) were defined as hospital-acquired. Out of the total cases, 96 (3·5%) were LTCF residents. Compared with community residents, LTCF residents over 75 years of age had a higher risk of iGAS infection (IRR = 1·7; 95% CI 1·3–2·1) and CFR (OR = 2·3; 95% CI 1·3–3·8). Amongst community-acquired cases, the risk of iGAS in LTCF residents between 75 and 84 years of age doubled (IRR = 2·7; 95% CI 1·8–3·9) compared with their community counterparts. The CFR among community-acquired cases was higher in LTCF residents than community residents (21% vs. 11%). Age remained associated with death in our final model. Our study showed that, even controlling for age, LTCF residents have a higher risk of acquiring and dying from iGAS. Whilst existing co-morbidities may explain this, it is reasonable to assume that the institutional setting may facilitate transmission. Therefore, cases in LTCF require prompt investigation together with a better understanding of factors contributing to the acquisition of infection.
Evidence of exposure of laughing doves (Spilopelia senegalensis) to West Nile and Usutu viruses in southern Tunisian oases
Authors: AYADI T. , HAMMOUDA A. , POUX A. , BOULINIER T. , LECOLLINET S. , SELMI S. 
Published: August 2017

SUMMARYIt has previously been suggested that southern Tunisian oases may be suitable areas for the circulation of flaviviruses. In order to anticipate and prevent possible epidemiological spread of flaviviruses in humans and domestic animals, the ecology of their transmission in the oasis system needs to be better understood. Thus, the aim of this study was to assess the seroprevalence of anti-flavivirus antibodies in the laughing dove (Spilopelia senegalensis), an abundant resident bird in Tunisian oases. Anti-flavivirus antibodies were detected in 17% of sampled doves. Ten per cent of the total tested doves were West Nile virus (WNV) seropositive and 4% were Usutu virus (USUV) seropositive, which provides the first evidence of USUV circulation in Tunisian birds. We also found that the occurrence probability of anti-flavivirus antibodies in dove plasma increased with decreasing distance to coast, suggesting that doves inhabiting coastal oases were more exposed to flaviviruses compared with those inhabiting inland oases. We also found significantly higher antibody occurrence probability in adult doves compared with young doves, which underlines the effect of exposure time. Overall, our results suggest that the laughing dove may be used for WNV and USUV surveillance in southern Tunisia. They also stress the need for investigations combining data on birds and mosquitoes to better understand the ecological factors governing the circulation of flaviviruses in this area.
History of child maltreatment and telomere length in immune cell subsets: Associations with stress- and attachment-related hormones
Authors: Boeck Christina , Krause Sabrina , Karabatsiakis Alexander , Schury Katharina , Gündel Harald , Waller Christiane , Kolassa Iris-Tatjana 
Published: August 2017

AbstractExperiencing maltreatment during childhood can have long-lasting consequences for both mental and physical health. Immune cell telomere length (TL) shortening might be one link between child maltreatment (CM) experiences and adverse health outcomes later in life. While the stress hormone cortisol has been associated with TL attrition, the attachment-related hormone oxytocin may promote resilience. In 15 mothers with and 15 age- and body mass index-matched mothers without CM, we assessed TL in peripheral blood mononuclear cells and selected immune cell subsets (monocytes, naive, and memory cytotoxic T cells) by quantitative fluorescence in situ hybridization, as well as peripheral cortisol and oxytocin levels. Memory cytotoxic T cells showed significantly shorter TL in association with CM, whereas TL in monocytes and naive cytotoxic T cells did not significantly differ between the two groups. Across both groups, cortisol was negatively associated with TL, while oxytocin was positively associated with TL in memory cytotoxic T cells. These results indicate that long-lived memory cytotoxic T cells are most affected by the increased biological stress state associated with CM. Keeping in mind the correlational and preliminary nature of the results, the data suggest that cortisol may have a damaging and oxytocin a protective function on TL.
Nutrition Facts Panel use is associated with diet quality and dietary patterns among Latinos with type 2 diabetes
Authors: Kollannoor-Samuel Grace , Segura-Pérez Sofia , Shebl Fatma M , Hawley Nicola L , Damio Grace , Chhabra Jyoti , Vega-López Sonia , Fernandez Maria Luz , Pérez-Escamilla Rafael 
Published: August 2017

AbstractObjectiveThe study aims were to (i) identify determinants of Nutrition Facts Panel (NFP) use and (ii) describe the association between NFP use and dietary intake among Latinos with type 2 diabetes.DesignBaseline cross-sectional data from a clinical trial were used to assess the association between NFP use and dietary intake. Diet was measured using two methods: (i) a diet quality score (the Healthy Eating Index-2010) derived from a single 24 h recall and (ii) dietary pattern (exploratory factor analyses) from an FFQ. Multivariable logistic and non-parametric quantile regressions were conducted, as appropriate.SettingsHartford County, Connecticut, USA.SubjectsLatino adults (n 203), ≥21 years of age, with diagnosed type 2 diabetes, glycosylated Hb≥7 %, and without medical conditions limiting physical activity.ResultsParticipants’ education level, diabetes-related knowledge and English speaking were positively associated with NFP use. At the higher percentiles of diet quality score, NFP use was significantly associated with higher diet quality. Similarly, NFP users were more likely to consume a ‘healthy’ dietary pattern (P=0·003) and less likely to consume a ‘fried snack’ pattern (P=0·048) compared with NFP non-users.ConclusionsThe association between reported NFP use and diet quality was positive and significantly stronger among participants who reported consuming a healthier diet. While NFP use was associated with a healthier dietary pattern, not using NFP was associated with a less-healthy, fried snack pattern. Longitudinal studies are needed to understand whether improving NFP use could be an effective intervention to improve diet quality among Latinos with type 2 diabetes.
Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids
Authors: Andaloussi Abdeljabar El , Habib Samar , Soylemes Gizem , Laknaur Archana , Elhusseini Heba , Al-Hendy Ayman , Ismail Nahed 
Published: August 2017

AbstractUterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were described in neoplasms; however, the contribution of autophagy to the pathogenesis of UF remains unknown. In this study, we demonstrate that autophagy is deregulated in human UF as evidenced by significant accumulation of autophagosome in human UF cells compared to normal myometrium cells. Analysis of the autophagy markers revealed an enhanced initiation of the autophagy in UF tissues compared to their adjacent myometrial tissues (MyoF). However, autophagosome maturation and flux was blocked in UF tissues, as marked by accumulation of LC3-B and P62 protein. This block was associated with defective expression of autophagy-related protein 4 (ATG4) in the UF tissues compared to MyoF in ~90% of patient samples. Silencing of ATG4D in normal human myometrial cells resulted in defective autophagy flux, enhanced cell proliferation and increased extracellular matrix production, which phenocopy UF cell line. This study indicates that impairment of autophagy flux secondary to defective expression of ATG4D expression is a new mechanistic aberration that contributes to UF pathogenesis. Targeting autophagy pathway could provide novel medical therapeutic approach for non-surgical treatment of UF.