bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of Resistance Training, Electroacupuncture and Huang Qi supplementation on skeletal muscle function and GLUT4 protein concentration in rats
Authors: Lee Sukho , Kim Kijeong , Lambrecht Nathalie J , Hong Junyoung , Liao Yi-Hung , Yoon Aram , Bernard Jeffrey R 
Published: July 2016

Objective To determine the effects and potential synergy of resistance training (RT), Huang Qi (HQ) herbal supplementation, and electroacupuncture (EA) on skeletal muscle mass, contractile properties, and components of the insulin signalling pathway in healthy Sprague Dawley rats. Methods Female Sprague Dawley rats were randomly assigned to one of five groups (n=8 each): control (CON), RT only, RT with EA (RT-EA), RT with HQ (RT-HQ), and RT combined with both EA and HQ (RT-EA-HQ). RT was performed using ladder climbing every other day for 8 weeks. Sparse-wave EA was applied for 15 min/day, 3 times/week for 8 weeks. HQ supplementation was provided via oral gavage daily for 8 weeks. Results RT significantly increased the muscle mass of the flexor hallucis longus (FHL) compared to CON. The isometric twitch and tetanic tension of the FHL in the RT-EA, RT-HQ, and RT-EA-HQ groups were significantly higher compared to CON and RT groups. RT-EA treatment (with or without HQ) significantly increased GLUT4 protein concentration but had no impact on Akt-2. Conclusions EA appears to be an effective treatment modality for increasing muscle mass and function when combined with RT. RT-EA may also be an effective method for improving glucose tolerance as a result of increases in GLUT4 protein concentration.
Validation of a portable, deployable system for continuous vital sign monitoring using a multiparametric wearable sensor and personalised analytics in an Ebola treatment centre
Authors: Steinhubl Steven R , Feye Dawit , Levine Adam C , Conkright Chad , Wegerich Stephan W , Conkright Gary 
Published: July 2016

BackgroundThe recent Ebola epidemic in West Africa strained existing healthcare systems well beyond their capacities due to the extreme volume and severity of illness of the patients. The implementation of innovative digital technologies within available care centres could potentially improve patient care as well as healthcare worker safety and effectiveness.MethodsWe developed a Modular Wireless Patient Monitoring System (MWPMS) and conducted a proof of concept study in an Ebola treatment centre (ETC) in Makeni, Sierra Leone. The system was built around a wireless, multiparametric ‘band-aid’ patch sensor for continuous vital sign monitoring and transmission, plus sophisticated data analytics. Results were used to develop personalised analytics to support automated alerting of early changes in patient status.ResultsDuring the 3-week study period, all eligible patients (n=26) admitted to the ETC were enrolled in the study, generating a total of 1838 hours of continuous vital sign data (mean of 67.8 hours/patient), including heart rate, heart rate variability, activity, respiratory rate, pulse transit time (inversely related to blood pressure), uncalibrated skin temperature and posture. All patients tolerated the patch sensor without problems. Manually determined and automated vital signs were well correlated. Algorithm-generated Multivariate Change Index, pulse transit time and arrhythmia burden demonstrated encouraging preliminary findings of important physiological changes, as did ECG waveform changes.ConclusionsIn this proof of concept study, we were able to demonstrate that a portable, deployable system for continuous vital sign monitoring via a wireless, wearable sensor supported by a sophisticated, personalised analytics platform can provide high-acuity monitoring with a continuous, objective measure of physiological status of all patients that is achievable in virtually any healthcare setting, anywhere in the world.
What are the factors associated with good mental health among Aboriginal children in urban New South Wales, Australia? Phase I findings from the Study of Environment on Aboriginal Resilience and Child Health (SEARCH)
Authors: Williamson Anna , D'Este Catherine , Clapham Kathleen , Redman Sally , Manton Toni , Eades Sandra , Schuster Leanne , Raphael Beverley 
Published: July 2016

ObjectiveTo identify the factors associated with ‘good’ mental health among Aboriginal children living in urban communities in New South Wales, Australia.DesignCross-sectional survey (phase I of a longitudinal study).Setting4 Aboriginal Community Controlled Health Services that deliver primary care. All services were located in urban communities in New South Wales, Australia.Participants1005 Aboriginal children aged 4–17 years who participated in phase I of the Study of Environment on Aboriginal Resilience and Child Health (SEARCH).Primary outcome measureCarer report version of the Strengths and Difficulties Questionnaire. Scores <17 were considered to indicate ‘good’ mental health for the purposes of this article.ResultsThe majority (72%) of SEARCH participants were not at high risk for emotional or behavioural problems. After adjusting for the relative contributions of significant demographic, child and carer health factors, the factors associated with good mental health among SEARCH children were having a carer who was not highly psychologically distressed (OR=2.8, 95% CI 1.6 to 5.1); not suffering from frequent chest, gastrointestinal or skin infections (OR=2.8, 95% CI 1.8 to 4.3); and eating two or more servings of vegetables per day (OR=2.1, 95% CI 1.2 to 3.8). Being raised by a foster carer (OR=0.2, 95% CI 0.01 to 0.71) and having lived in 4 or more homes since birth (OR=0.62, 95% CI 0.39 to 1.0) were associated with significantly lower odds of good mental health. Slightly different patterns of results were noted for adolescents than younger children.ConclusionsMost children who participated in SEARCH were not at high risk for emotional or behavioural problems. Promising targets for efforts to promote mental health among urban Aboriginal children may include the timely provision of medical care for children and provision of additional support for parents and carers experiencing mental or physical health problems, for adolescent boys and for young people in the foster care system.
Protocol of the Australasian Malignant Pleural Effusion-2 (AMPLE-2) trial: a multicentre randomised study of aggressive versus symptom-guided drainage via indwelling pleural catheters
Authors: Azzopardi Maree , Thomas Rajesh , Muruganandan Sanjeevan , Lam David C L , Garske Luke A , Kwan Benjamin C H , Rashid Ali Muhammad Redzwan S , Nguyen Phan T , Yap Elaine , Horwood Fiona C , Ritchie Alexander J , Bint Michael , Tobin Claire L , Shrestha Ranjan , Piccolo Francesco , De Chaneet Christian C , Creaney Jenette , Newton Robert U , Hendrie Delia , Murray Kevin , Read Catherine A , Feller-Kopman David , Maskell Nick A , Lee Y C Gary 
Published: July 2016

IntroductionMalignant pleural effusions (MPEs) can complicate most cancers, causing dyspnoea and impairing quality of life (QoL). Indwelling pleural catheters (IPCs) are a novel management approach allowing ambulatory fluid drainage and are increasingly used as an alternative to pleurodesis. IPC drainage approaches vary greatly between centres. Some advocate aggressive (usually daily) removal of fluid to provide best symptom control and chance of spontaneous pleurodesis. Daily drainages however demand considerably more resources and may increase risks of complications. Others believe that MPE care is palliative and drainage should be performed only when patients become symptomatic (often weekly to monthly). Identifying the best drainage approach will optimise patient care and healthcare resource utilisation.Methods and analysisA multicentre, open-label randomised trial. Patients with MPE will be randomised 1:1 to daily or symptom-guided drainage regimes after IPC insertion. Patient allocation to groups will be stratified for the cancer type (mesothelioma vs others), performance status (Eastern Cooperative Oncology Group status 0–1 vs ≥2), presence of trapped lung (vs not) and prior pleurodesis (vs not). The primary outcome is the mean daily dyspnoea score, measured by a 100 mm visual analogue scale (VAS) over the first 60 days. Secondary outcomes include benefits on physical activity levels, rate of spontaneous pleurodesis, complications, hospital admission days, healthcare costs and QoL measures. Enrolment of 86 participants will detect a mean difference of VAS score of 14 mm between the treatment arms (5% significance, 90% power) assuming a common between-group SD of 18.9 mm and a 10% lost to follow-up rate.Ethics and disseminationThe Sir Charles Gairdner Group Human Research Ethics Committee has approved the study (number 2015-043). Results will be published in peer-reviewed journals and presented at scientific meetings.Trial registration numberACTRN12615000963527; Pre-results.
Association between psychological distress and dietary intake among evacuees after the Great East Japan Earthquake in a cross-sectional study: the Fukushima Health Management Survey
Authors: Uemura Mayu , Ohira Tetsuya , Yasumura Seiji , Otsuru Akira , Maeda Masaharu , Harigane Mayumi , Horikoshi Naoko , Suzuki Yuriko , Yabe Hirooki , Takahashi Hideto , Nagai Masato , Nakano Hironori , Zhang Wen , Hirosaki Mayumi , Abe Masafumi 
Published: July 2016

ObjectivePsychological distress is generally associated with poor dietary intake, but this has never been investigated among residents after a major disaster. We attempted to reveal the associations between dietary intake and non-specific mental health distress as well as traumatic symptoms among evacuees after the Great East Japan Earthquake of 2011.MethodsIn this cross-sectional analysis of 63 047 evacuees (27 901 men, 35 146 women) who responded to The Fukushima Health Management Survey in 2012, non-specific mental health distress was assessed using the Kessler-6 (K6) scale, while traumatic symptoms were evaluated using the Post-traumatic Stress Disorder (PTSD) Checklist—Stressor-Specific Version (PCL-S). The outcome was ‘low frequency’—meaning a daily consumption in the 25th centile or less according to the food frequency questionnaire (FFQ)—of 19 targeted food items. Logistic regression analysis was used to estimate ORs and 95% CIs adjusted for demographic, lifestyle-related and disaster-related factors.ResultsOf the participants, 14.7% suffered non-specific mental health distress, and 21.2% exhibited traumatic symptoms. Multivariable adjusted logistic regression analysis showed that the former were likely to have a low intake frequency of certain foods, such as rice and bread, fish, meat, vegetables or fruit (non-juice), soya bean products, milk, and yogurt or lactobacillus drinks; the latter were also likely to have a low intake frequency of certain foods, including rice and bread, fish, meat, vegetables (non-juice), milk and yogurt or lactobacillus drinks, but conversely consumed vegetable and fruit juices more often. These associations between dietary intake and non-specific mental health distress, as well as traumatic symptoms, were predominantly observed in women.ConclusionsPsychological distress after the Great East Japan Earthquake among evacuees was associated with a low intake frequency of certain foods, and the association was predominantly observed in women.
Identifying process and outcome indicators of successful transitions from child to adult mental health services: protocol for a scoping review
Authors: Cleverley Kristin , Bennett Kathryn , Jeffs Lianne 
Published: July 2016

IntroductionA significant proportion of youth need to transition from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS); however, the transition process is not well understood and often experienced poorly by youth. In the effort to design and evaluate standards of practice for transitions, there is a need to identify key elements of a successful transition. The objectives of this scoping review are to: (1) identify definitions of successful transitions from CAMHS to AMHS; and (2) identify indicators that have been used to measure CAMHS–AMHS transition care processes and quality, and outcomes.MethodsWe will search 8 electronic bibliographic databases from 1980 to 2016 (eg, Medline, EMBASE, PsycINFO), professional associations, policy documents, and other grey literature to identify relevant material. We will include experimental, quasi-experimental, observational studies, and non-research studies (guidelines, narrative reviews, policy documents) examining the transition from CAMHS to AMHS. 2 raters will independently screen each retrieved title and abstract for eligibility using the study inclusion criteria (level 1), and then will independently assess full-text articles to determine if these meet the inclusion criteria (level 2). Data extraction will be completed and results will be synthesised both quantitatively and qualitatively.Ethics and disseminationThe results of the scoping review will be used to develop a set of indicators that will be prioritised and evaluated in a Delphi consensus study. This will serve as a foundation for the development of the first instrument to assess the quality and success of CAMHS–AMHS transitions. Ethics approval is not required for this scoping study.
Optimal Levels of All Major Cardiovascular Risk Factors in Younger Age and Functional Disability in Older Age
Authors: Vu Thanh-Huyen T. , Lloyd-Jones Donald M. , Liu Kiang , Stamler Jeremiah , Garside Daniel B. , Daviglus Martha L. 
Published: July 2016

Background—
The associations of optimal levels of all major cardiovascular disease risk factors, that is, low risk, in younger age with subsequent cardiovascular disease morbidity and mortality have been well documented. However, little is known about associations of low-risk profiles in younger age with functional disability in older age.

Methods and Results—

The sample included 6014 participants from the Chicago Heart Association Detection Project in Industry Study. Low-risk status, defined as untreated systolic/diastolic blood pressure ≤120/≤80 mm Hg, untreated serum total cholesterol <5.18 mmol/l, not smoking, body mass index < 25 kg/m
2
, and no diabetes mellitus, was assessed at baseline (1967 to 1973). Functional disability, categorized as (1) any disability in activities of daily living (ADLs), (2) any disability in instrumental ADLs but not in ADL, or (3) no disability, was assessed from the 2003 health survey. There were 39% women, 4% Black, with a mean age of 43 years and 6% low-risk status at baseline. After 32 years, 7% reported having limitations in performing any ADL and 11% in any instrumental ADL only. The prevalence of any ADL limitation was lowest in low-risk people and increased in a graded fashion with less-favorable risk factor groups (
P
trend <0.001). Compared with those with 2+ high-risk factors, the multivariable-adjusted odds of having any disability in ADLs versus no disability in people with low risk, any moderate risk, and 1 high-risk factor at baseline were lower by 58%, 48%, and 37%, respectively. Results were similar for instrumental ADLs, in both men and women.

Conclusions—
Having an optimal cardiovascular disease risk factor profile at younger age is associated with the lowest rate of functional disability in older age.
Does Population Affect the Location of Flash Flood Reports?
Authors: Marjerison Rebecca D. , Walter M. Todd , Sullivan Patrick J. , Colucci Stephen J. 
Published: July 2016

AbstractFlash floods cause more fatalities than any other weather-related natural hazard and cause significant damage to property and infrastructure. It is important to understand the underlying processes that lead to these infrequent but high-consequence events. Accurately determining the locations of flash flood events can be difficult, which impedes comprehensive research of the phenomena. While some flash floods can be detected by automated means (e.g., streamflow gauges), flash floods (and other severe weather events) are generally based on human observations and may not reflect the actual distribution of event locations. The Storm Data–Storm Events Database, which is produced from National Weather Service reports, was used to locate reported flash floods within the forecast area of the Binghamton, New York, Weather Forecast Office between 2007 and 2013. The distribution of those reports was analyzed as a function of environmental variables associated with flood generation including slope, impervious area, soil saturated hydraulic conductivity ksat, representative rainfall intensity, and representative rainfall depth, as well as human population. A spatial conditional autoregressive model was used to test the hypothesis that flash flood reports are made more frequently in areas with higher populations, even when other flood-generating processes are considered. Slope, soil saturated hydraulic conductivity, and impervious area are significant predictors of flash flood reports. When population is added as a predictor, the model is similarly robust, but impervious area and ksat are no longer significant predictors. These results may challenge the assumption that flash flood reports are strongly biased by population.
Aircraft Measurements and Numerical Simulations of an Expansion Fan off the California Coast
Authors: Parish Thomas R. , Rahn David A. , Leon David C. 
Published: July 2016

AbstractMountains along the California coastline play a critical role in the dynamics of marine atmospheric boundary layer (MBL) airflow in the vicinity of the shoreline. Large changes in the MBL topology have been known to occur downwind of points and capes along the western coast of the United States. Large spatial gradients in wind and temperature become established that can cause anomalous electromagnetic wave propagation. Detailed airborne measurements using the University of Wyoming King Air were conducted to study the adjustment of the MBL to the Point Arguello and Point Conception headlands. Pronounced thinning of the MBL consistent with an expansion fan occurred to the south of Point Conception on 13 June 2012. A sharp cloud edge was collocated with the near collapse of the MBL. D-value cross sections derived from differential GPS altitude measurements allow assessment of the vertical profile of the horizontal pressure gradient force and hence thermal wind forcing in response to the near collapse of the MBL. The Weather Research and Forecasting Model was run with a 1-km grid spacing to examine the atmospheric adjustment around Point Conception during this period. Results from the simulations including the vertical cross sections of the horizontal pressure gradient force were consistent with the aircraft observations. Model results suggest that divergence occurs as the flow rounds Point Conception, characteristic of an expansion fan. Wind speeds in the MBL increase coincident with the decrease in MBL thickness, and subsiding flow associated with the near collapse of the MBL is responsible for the sharp cloud edge.
Evaluation of Cerebral Hemodynamics and Tissue Morphology of In Vivo Rat Brain Using Spectral Diffuse Reflectance Imaging
Authors: Nishidate Izumi , Ishizuka Tomohiro , Mustari Afrina , Yoshida Keiichiro , Kawauchi Satoko , Sato Shunichi , Sato Manabu 
Published: July 2016

We investigated a quantitative imaging of reduced scattering coefficients μs’( λ) and the absorption coefficients μa( λ) of in vivo cortical tissues in the range from visible to near-infrared (NIR) wavelengths based on diffuse reflectance spectral imaging technique. In this method, diffuse reflectance images of in vivo cortical tissue are acquired at nine wavelengths (500, 520, 540, 560, 570, 580, 600, 730, and 760 nm). A multiple regression analysis aided by the Monte Carlo simulation for the absorbance spectra is then utilized to estimate the optical coefficients of cortical tissue. This analysis calculates the concentration of oxygenated hemoglobin and that of deoxygenated hemoglobin, the scattering amplitude a and the scattering power b. The spectrum of absorption coefficient is deduced from the estimated concentrations of oxygenated hemoglobin and deoxygenated hemoglobin. The spectrum of reduced scattering coefficient is determined by the estimated scattering amplitude and scattering power. The particle size distribution of microstructure is calculated from the estimated scattering power b for evaluating the morphological change in brain tissue quantitatively. Animal experiments with in vivo exposed brain of rats demonstrated that the responses of the absorption properties to hyperoxic and anoxic conditions are in agreement with the expected well-known cortical hemodynamics. The average particle size was significantly reduced immediately after the onset of anoxia and then it was changed into an increase, which implied the swelling and shrinkage of the cellular and subcellular structures induced by loss of tissue viability in brain tissue.
Treatment outcomes and lessons learned from 5134 cases of outpatient office-based endovascular procedures in a vascular surgical practice
Authors: Lin Peter H , Yang Keun-Ho , Kollmeyer Kenneth R , Uceda Pablo V , Ferrara Craig A , Feldtman Robert W , Caruso Joseph , Mcquade Karen , Richmond Jasmine L , Kliner Cameron E , Egan Kaitlyn E , Kim Walter , Saines Marius , Leichter Rhoda , Ahn Samuel S 
Published: July 2016

Introduction The office-based endovascular facility has increased in number recently due in part to expedient patient experience. This study analyzed treatment outcomes of procedures performed in our office-based endovascular suite. Methods Treatment outcomes of 5134 consecutive procedures performed in our office-based endovascular suites from 2006 to 2013 were analyzed. Five sequential groups (group I–V) of 1000 consecutive interventions were compared with regard to technical success and treatment outcomes. Results Our patients included 2856 (56%) females and 2267 (44%) males. Procedures performed included diagnostic arteriogram, arterial interventions, venous interventions, dialysis access interventions, and venous catheter management, which were 1024 (19.9%), 1568 (30.6%), and 3073 (60.0%), 621(12.1%), and 354 (6.9%), respectively. The complication rates for group I, II, III, IV, and V were 3%, 1.5%, 1%, 1.1%, and 0.7%, respectively. The complication rate was higher in group I when compared to each of the remaining four groups ( p < 0.05). Nine patients (0.18%) died within the 30-day period following their procedures, and none were procedure related. Conclusions Endovascular procedure can be performed safely in an office-based facility with excellent outcomes. Lessons learned in establishing office-based endovascular suites with efforts to reduce procedural complications and optimize quality patient care are discussed.