bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes
Authors: Jax Thomas , Stirban Alin , Terjung Arne , Esmaeili Habib , Berk Andreas , Thiemann Sandra , Chilton Robert , von Eynatten Maximilian , Marx Nikolaus 
Published: January 2017

Abstract
Background
Studies of dipeptidyl peptidase (DPP)-4 inhibitors report heterogeneous effects on endothelial function in patients with type 2 diabetes (T2D). This study assessed the effects of the DPP-4 inhibitor linagliptin versus the sulphonylurea glimepiride and placebo on measures of macro- and microvascular endothelial function in patients with T2D who represented a primary cardiovascular disease prevention population.

Methods
This crossover study randomised T2D patients (n = 42) with glycated haemoglobin (HbA1c) ≤7.5%, no diagnosed macro- or microvascular disease and on stable metformin background to linagliptin 5 mg qd, glimepiride 1–4 mg qd or placebo for 28 days. Fasting and postprandial macrovascular endothelial function, measured using brachial flow-mediated vasodilation, and microvascular function, measured using laser-Doppler on the dorsal thenar site of the right hand, were analysed after 28 days.

Results
Baseline mean (standard deviation) age, body mass index and HbA1c were 60.3 (6.0) years, 30.3 (3.0) kg/m2 and 7.41 (0.61)%, respectively. After 28 days, changes in fasting flow-mediated vasodilation were similar between the three study arms (treatment ratio, gMean [90% confidence interval]: linagliptin vs glimepiride, 0.884 [0.633–1.235]; linagliptin vs placebo, 0.884 [0.632–1.235]; glimepiride vs placebo, 1.000 [0.715–1.397]; P = not significant for all comparisons). Similarly, no differences were seen in postprandial flow-mediated vasodilation. However, under fasting conditions, linagliptin significantly improved microvascular function as shown by a 34% increase in hyperaemia area (P = 0.045 vs glimepiride), a 34% increase in resting blow flow (P = 0.011 vs glimepiride, P = 0.003 vs placebo), and a 25% increase in peak blood flow (P = 0.009 vs glimepiride, P = 0.003 vs placebo). There were no significant differences between treatments in postprandial changes. Linagliptin had no effect on heart rate or blood pressure. Rates of overall adverse events with linagliptin, glimepiride and placebo were 27.5, 61.0 and 35.0%, respectively. Fewer hypoglycaemic events were seen with linagliptin (5.0%) and placebo (2.5%) than with glimepiride (39.0%).

Conclusions
Linagliptin had no effect on macrovascular function in T2D, but significantly improved microvascular function in the fasting state.
Trial registration ClinicalTrials.gov identifier—NCT01703286; registered October 1, 2012
Clinically insignificant trunnionosis in large-diameter metal-on-polyethylene total hip arthroplasty
Authors: Hothi H. S. , Kendoff D. , Lausmann C. , Henckel J. , Gehrke T. , Skinner J. , Hart A. 
Published: January 2017

Objectives Mechanical wear and corrosion at the head-stem junction of total hip arthroplasties (THAs) (trunnionosis) have been implicated in their early revision, most commonly in metal-on-metal (MOM) hips. We can isolate the role of the head-stem junction as the predominant source of metal release by investigating non-MOM hips; this can help to identify clinically significant volumes of material loss and corrosion from these surfaces. Methods In this study we examined a series of 94 retrieved metal-on-polyethylene (MOP) hips for evidence of corrosion and material loss at the taper junction using a well published visual grading method and an established roundness-measuring machine protocol. Hips were retrieved from 74 male and 20 female patients with a median age of 57 years (30 to 76) and a median time to revision of 215 months (2 to 324). The reasons for revision were loosening of both the acetabular component and the stem (n = 29), loosening of the acetabular component (n = 58) and infection (n = 7). No adverse tissue reactions were reported by the revision surgeons. Results Evidence of corrosion was observed in 55% of hips. The median Goldberg taper corrosion score was 2 (1 to 4) and the annual rate of material loss at the taper was 0.084 mm3/year (0 to 0.239). The median trunnion corrosion score was 1 (1 to 3). Conclusions We have reported a level of trunnionosis for MOP hips with large-diameter heads that were revised for reasons other than trunnionosis, and therefore may be clinically insignificant. Cite this article: H. S. Hothi, D. Kendoff, C. Lausmann, J. Henckel, T. Gehrke, J. Skinner, A. Hart. Clinically insignificant trunnionosis in large-diameter metal-on-polyethylene total hip arthroplasty. Bone Joint Res 2017;6:52–56. DOI: 10.1302/2046-3758.61.BJR-2016-0150.R2.
Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear
Authors: Gumucio J. P. , Flood M. D. , Bedi A. , Kramer H. F. , Russell A. J. , Mendias C. L. 
Published: January 2017

Objectives Rotator cuff tears are among the most frequent upper extremity injuries. Current treatment strategies do not address the poor quality of the muscle and tendon following chronic rotator cuff tears. Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that activates many genes that are important in skeletal muscle regeneration. HIF-1α is inhibited under normal physiological conditions by the HIF prolyl 4-hydroxylases (PHDs). In this study, we used a pharmacological PHD inhibitor, GSK1120360A, to enhance the activity of HIF-1α following the repair of a chronic cuff tear, and measured muscle fibre contractility, fibrosis, gene expression, and enthesis mechanics. Methods Chronic supraspinatus tears were induced in adult rats, and repaired 28 days later. Rats received 0 mg/kg, 3 mg/kg, or 10 mg/kg GSK1120360A daily. Collagen content, contractility, fibre type distribution and size, the expression of genes involved in fibrosis, lipid accumulation, atrophy and inflammation, and the mechanical properties of the enthesis were then assessed two weeks following surgical repair. Results At two weeks following repair, treatment groups showed increased muscle mass but there was a 15% decrease in force production in the 10 mg/kg group from controls, and no difference between the 0 mg/kg and the 3 mg/kg groups. There was a decrease in the expression of several gene transcripts related to matrix accumulation and fibrosis, and a 50% decrease in collagen content in both treated groups compared with controls. Additionally, the expression of inflammatory genes was reduced in the treated groups compared with controls. Finally, PHD inhibition improved the maximum stress and displacement to failure in repaired tendons. Conclusions GSK1120360A resulted in improved enthesis mechanics with variable effects on muscle function. PHD inhibition may be beneficial for connective tissue injuries in which muscle atrophy has not occurred. Cite this article: J. P. Gumucio, M. D. Flood, A. Bedi, H. F. Kramer, A. J. Russell, C. L. Mendias. Inhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear. Bone Joint Res 2017;6:57–65. DOI: 10.1302/2046-3758.61.BJR-2016-0232.R1.
Whole body hyperthermia, but not skin hyperthermia, accelerates brain and locomotor limb circulatory strain and impairs exercise capacity in humans
Authors: Trangmar Steven J. , Chiesa Scott T. , Kalsi Kameljit K. , Secher Niels H. , González‐Alonso José 
Published: January 2017

AbstractCardiovascular strain and hyperthermia are thought to be important factors limiting exercise capacity in heat‐stressed humans, however, the contribution of elevations in skin (Tsk) versus whole body temperatures on exercise capacity has not been characterized. To ascertain their relationships with exercise capacity, blood temperature (TB), oxygen uptake (V̇O2), brain perfusion (MCA Vmean), locomotor limb hemodynamics, and hematological parameters were assessed during incremental cycling exercise with elevated skin (mild hyperthermia; HYPmild), combined core and skin temperatures (moderate hyperthermia; HYPmod), and under control conditions. Both hyperthermic conditions increased Tsk versus control (6.2 ± 0.2°C; P < 0.001), however, only HYPmod increased resting TB, leg blood flow and cardiac output (Q̇), but not MCA Vmean. Throughout exercise, Tsk remained elevated in both hyperthermic conditions, whereas only TB was greater in HYPmod. At exhaustion, oxygen uptake and exercise capacity were reduced in HYPmod in association with lower leg blood flow, MCA Vmean and mean arterial pressure (MAP), but similar maximal heart rate and TB. The attenuated brain and leg perfusion with hyperthermia was associated with a plateau in MCA and two‐legged vascular conductance (VC). Mechanistically, the falling MCA VC was coupled to reductions in PaCO2, whereas the plateau in leg vascular conductance was related to markedly elevated plasma [NA] and a plateau in plasma ATP. These findings reveal that whole‐body hyperthermia, but not skin hyperthermia, compromises exercise capacity in heat‐stressed humans through the early attenuation of brain and active muscle blood flow.
Reduced firing rates of high threshold motor units in response to eccentric overload
Authors: Balshaw Tom G. , Pahar Madhu , Chesham Ross , Macgregor Lewis J. , Hunter Angus M. 
Published: January 2017

AbstractAcute responses of motor units were investigated during submaximal voluntary isometric tasks following eccentric overload (EO) and constant load (CL) knee extension resistance exercise. Ten healthy resistance‐trained participants performed four experimental test sessions separated by 5 days over a 20 day period. Two sessions involved constant load and the other two used eccentric overload. EO and CL used both sessions for different target knee eccentric extension phases; one at 2 sec and the other at 4 sec. Maximal voluntary contractions (MVC) and isometric trapezoid efforts for 10 sec at 70% MVC were completed before and after each intervention and decomposed electromyography was used to measure motor unit firing rate. The firing rate of later recruited, high‐threshold motor units declined following the 2‐sec EO but was maintained following 2sec CL (P < 0.05), whereas MUFR for all motor units were maintained for both loading types following 4‐sec extension phases. MVC and rate of force development where maintained following both EO and CL and 2 and 4 sec phases. This study demonstrates a slower firing rate of high‐threshold motor units following fast eccentric overload while MVC was maintained. This suggests that there was a neuromuscular stimulus without cost to the force‐generating capacity of the knee extensors.
Method for Identification of Results of Dynamic Overloads in Assessment of Safety Use of the Mine Auxiliary Transportation System
Authors: Tokarczyk Jarosław 
Published: January 2017

Abstract
Method for identification the effects of dynamic overload affecting the people, which may occur in the emergency state of suspended monorail is presented in the paper. The braking curve using MBS (Multi-Body System) simulation was determined. For this purpose a computational model (MBS) of suspended monorail was developed and two different variants of numerical calculations were carried out. An algorithm of conducting numerical simulations to assess the effects of dynamic overload acting on the suspended monorails’ users is also posted in the paper. An example of computational model FEM (Finite Element Method) composed of technical mean and the anthropometrical model ATB (Articulated Total Body) is shown. The simulation results are presented: graph of HIC (Head Injury Criterion) parameter and successive phases of dislocation of ATB model. Generator of computational models for safety criterion, which enables preparation of input data and remote starting the simulation, is proposed.
Visual accounts of Finnish and Greek teenagers’ perceptions of their multilingual language and literacy practices
Authors: Pitkänen-Huhta Anne , Rothoni Anastasia 
Published: January 2017

AbstractThis paper uses visual methods to explore how teenagers in two different European countries (Finland and Greece) personally relate to their first language and to English, which is widely used in the everyday lives of young people in both countries. Our data comprise sets of self-made visualizations in which 14- to 16-year-old teenagers depict their personal relationship to their first language (Finnish/Greek) and to English. Theoretically and methodologically, we subscribe to socio-culturally oriented research on (foreign language) literacy and language learning and recent studies on multilingualism. Overall, by offering a detailed account of the variety of representation forms and meaning-making symbols employed by our participants in their visual products, our analysis in this paper highlights the common but also diverse perceptions, values and attitudes that young people from two different European contexts bring to their practices and their encounters with English and other languages in their lives. By revealing the personal meanings and values attached by teenagers to English, our analysis also provides indirect insights into the multiple ways English is locally encountered, appropriated and drawn upon by young people in two different countries to serve their own purposes.
Exploring the Ways Cinematography Affects Viewers’ Perceived Empathy towards Onscreen Characters
Authors: Lotman Elen 
Published: January 2017

Abstract
In the history of cinematography there is a noticeable tradition to deliberately highlight the elements that accentuate space and spatiality in the shots. At the same time, there is also a contrary tradition, i.e. the conscious reduction of spatiality with the help of artistic tools in order to evoke a feeling of alienation. In this article I will argue that it is highly likely that the visual reinforcement of depth has become one of a cinematographer’s most frequently used tools, because it plays an important role in the audience’s perceived empathy towards onscreen characters. Since the practices of art-making – e.g. cinematography – represent a way that the empirical experience accumulated in professional practices reflects underlying neural processes, this article will first draw upon evidence from the common tenets of cinematography and reflect on how these correspond to the respective phenomena in human perception and cognition. The second part of the article examines the theory of the para-dramatic and eso-dramatic factors established by Gal Raz and Talma Hendler as it applies to cinematography; thereby suggesting possibilities for broadening the theoretical foundations of the twofold division of the causes for the viewers’ empathetic responses. The article will also introduce the results from a pilot experiment. However, I will not argue that the rendering of cinematographic space and drawing attention to certain areas are superior tools for creating filmic empathy. I will rather point out that they are often used by cinematographers when they want to create an immersive experience, and therefore, there is reason to believe that a connection exists between emotional empathy and the usage of these cinematographic tools.
High Temperature Mechanical Behavior of MgAl2O4-YAG Eutectic Ceramic In Situ Composites by Float Zone Method
Authors: Abalı Serkan 
Published: January 2017

AbstractThe directionally solidified eutectic MgAl2O4-Y3Al5O12 crystal was prepared at a pressure of 0.4 MPa of ambient nitrogen gas by the high frequency induction heated floating zone furnace. In order to determine the high temperature characteristics, directionally solidified MgAl2O4-Y3Al5O12 eutectic phase has been analyzed with creep test, tensile strength, young modulus and fracture toughness at the various temperatures and the microstructural variations have been studied according to the analysis results. It has been seen that directionally solidified with zone melting MgAl2O4-YAG eutectic ceramic which has given the value of 168 MPa below 10−6/s strain rate at 1,700 °C temperature has revealed minimum stress.
Compact Discrete Gradient Schemes for Nonlinear Schrödinger Equations
Authors: Yin Xiuling , Zhang Chengjian , Zhang Jingjing 
Published: January 2017

Abstract
This paper proposes two schemes for a nonlinear Schrödinger equation with four-order spacial derivative by using compact scheme and discrete gradient methods. They are of fourth-order accuracy in space. We analyze two discrete invariants of the schemes. The numerical experiments are implemented to investigate the efficiency of the schemes.
Mixed Convection Boundary Layer Flow of Williamson Fluid with Slip Conditions Over a Stretching Cylinder by Using Keller Box Method
Authors: Salahuddin T. , Malik M. Y. , Hussain Arif , Awais M. , Bilal S. 
Published: January 2017

Abstract
The aim of the present analysis is to examine the effects of slip boundary conditions and mixed convection flow of Williamson fluid over a stretching cylinder. The boundary layer partial differential equations are transformed into ordinary differential equations by using group theory transformations. The required ordinary differential equations are solved numerically by using implicit finite difference method known as Keller box method. The influence of dimensionless physical parameters on velocity and temperature profile as well as skin friction coefficient and local Nusselt number are presented graphically. Comparison has been made to the previous literature in order to check the accuracy of the method.
The seasonal variability of the amount of global solar radiation reaching the ground in urban and rural areas on the example of Warsaw and Belsk
Authors: Nelken Kinga , Leziak Kamil 
Published: January 2017

Abstract
The aim of this paper is to determine the contemporary differences in the inflow of global solar radiation in Warsaw (urban station) and Belsk (rural station). The meteorological data used comprised daily sums of global solar radiation (in MJ•m−2) and the duration of sunshine (in hours) for the period 2008 2014. On clear days in spring and summer, the rural area receives more solar radiation in comparison to the urban area, whereas in autumn a reverse relationship occurs. On cloudy days in all seasons, the rural area receives more solar radiation than the urban area, and the relationship is the strongest in winter. Differences between urban and rural areas on cloudy days are smaller than those observed on clear days.
Financial Planning and Management Practices of Electrical Contractors
Authors: Lucko Gunnar 
Published: January 2017

Abstract
Contractors must carefully manage their cash outflows (e.g., for materials to enable their work) and inflows (after the work) to be profitable, particularly in an economy that is still recovering from the 2008–2012 recession that grew out of the mortgage crisis. Their importance for business success is undisputed, as bankruptcies due to insufficient cash flow underline. Therefore, this study investigated current business practices of electrical contracting companies of different sizes with respect to their financial planning and management. A detailed questionnaire was developed with best guidelines on survey studies and pilot testing. It was sent to members of the National Electrical Contractors Association. Respondent anonymity was ensured. The survey recorded demographics, business practices, operating conditions, and other important factors using 57 subquestions. Each section allowed feedback to clarify the numerical responses. Responses were well distributed across company sizes, so that the results are representative for the entire industry. The results indicated that contractors generally have a substantial amount of experience in financial decision making. Their approach is conservative and focuses on healthy growth. Yet, opportunities to fine-tune business practices are identified, e.g., immediate invoicing, considering discounts to accelerate payment receipts, attempting to negotiate and use favorable credit terms, reviewing payment performance, and performing frequent cash flow forecasts. Some of the differences in the responses can be attributed to different company sizes. To help especially smaller companies in planning their cash flow, a spreadsheet for implementation has been created.
Factorizing the Changes in CO2 Emissions from Indian Road Passenger Transport: A Decomposition Analysis
Authors: Gupta Monika , Singh Sanjay 
Published: January 2017

Abstract
The main aim of this paper is to analyse the role of different factors responsible for CO2 emission from Indian road passenger transport with the help of Logarithmic Mean Divisia Index over the period of 1971-2011. CO2 emission increase is decomposed into five major factors - emission coefficient, transport energy intensity, transport activity, economic growth, and population. Findings suggest that economic growth, transport activity and population have a significant positive role in increasing CO2 emission from road passenger transport, whereas energy intensity plays a negative role in CO2 emission increase. Emission coefficient has also a negative role in CO2 emission increase during all the periods except during 1971-81. Therefore, emission coefficient and energy intensity are the two most important factors for policy design and implementation to reduce CO2 emission from the sector.
Relationship between Toxic Leadership and Job Stress of Knowledge Workers
Authors: Hadadian Zagross , Zarei Jamileh 
Published: January 2017

Abstract
Nowadays, different levels of stress and nervousness can be found in organizations. Owing to the fact that employees spend most of their time in organizations, stress may affect the health of employees. Hence, study of stress and the factors that make stress can be a viable decision in that by eliminating these factors organizations can have healthier employees. This study is a correlation study which aims to determine the possible relationship between toxic leadership and job stress. Data collection tools including two standard questionnaires were used. The questionnaire adopted from toxic leadership (Schmidt and Hanges 2009) to measure the toxic leadership in organizations and the NIOSH Generic Job Stress Questionnaire (Hurrell and McLaney 1988) to measure the job stress. In order to analyze the data SPSS software was used. Results show that there is a significant direct relationship between toxic leadership and the job stress of employees. In other words, the more toxic leadership perceived by employees, the more job stress they feel.
Computational Fluid Dynamics Methods and Their Applications in Medical Science
Authors: Kowalewski Wojciech , Roszak Magdalena , Kołodziejczak Barbara , Ren-Kurc Anna , Bręborowicz Andrzej 
Published: January 2017

Abstract
As defined by the National Institutes of Health: “Biomedical engineering integrates physical, chemical, mathematical, and computational sciences and engineering principles to study biology, medicine, behavior, and health”. Many issues in this area are closely related to fluid dynamics. This paper provides an overview of the basic concepts concerning Computational Fluid Dynamics and its applications in medicine.