bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navien catheter experience in neuroendovascular interventions
Authors: Jindal Gaurav , Giacon Luciano , Iyoha Moronke , Miller Timothy , Aldrich Francois , Simard Marc , Shivashankar Ravishankar , Gandhi Dheeraj 
Published: September 2017

Purpose Advancements in catheter technology have allowed for greater flexibility and trackability. We report 265 consecutive, single-center neurointerventional cases using the Navien guide catheter. Materials and methods Retrospective analysis was performed of consecutive intracranial endovascular procedures utilizing the Navien catheter. Data collected included procedure type, catheters, guide catheter position, cervical access artery tortuosity grade and complications. Results The 5 French catheter was used in 130 cases. The 6 French catheter was used in 135 cases. Access was via the internal carotid artery in 204, external carotid artery in 10, and vertebral artery in 51 cases. Catheter tip position was in the petrous segment of the internal carotid artery in 36.6% (97/265), distal cervical internal carotid artery in 13.9% (37/265), cavernous internal carotid artery in 10.2% (27/265), proximal or mid cervical internal carotid artery in 5.6% (15/265), supraclinoid internal carotid artery in 0.8% (2/265), and intradural vertebral artery in 0.8% (2/265) of cases. Catheter position was not determined in 18.9% (50/265) of cases. Proximal vessel tortuosity (grade B or C) was present in 98 cases (37%), and the catheter was tracked distal to the tortuosity in 93% (91/98) of these cases. The overall success rate without catheter complication was 97% (258/265). The Navien was replaced by another catheter in 1.9% (5/265) of cases. There was one cervical artery dissection (0.4%) and one severe vasospasm (0.4%) necessitating Navien removal. Conclusions The Navien guide catheter provided distal access support for neuroendovascular interventions in nearly all cases, including cases with proximal artery tortuosity, with a low rate of catheter-related complications.
One-year efficacy and safety of the Trufill DCS Orbit and Orbit Galaxy detachable coils in the endovascular treatment of intracranial aneurysms: Results from the TRULINE study
Authors: Gory Benjamin , Huot Laure , Riva Roberto , Labeyrie Paul E , Levrier Olivier , Lebedinsky Ariel , Brunel Hervé , Gauvrit Jean-Yves , Blanc Raphael , Chabert Emmanuel , Derex Laurent , Emery Evelyne , Nicolas Arnaud , Desal Hubert , Rodesch Georges , Turjman Francis 
Published: September 2017

Background and purpose No series reported the mid-term results of Trufill DCS Orbit and Orbit Galaxy detachable coils with independent evaluation. We present the one-year safety and efficacy of these coils in real-life routine clinical practice. Methods A total of 167 patients with 167 aneurysms (39.1% ruptured) were enrolled in the prospective TRULINE study. The primary endpoint was the safety, assessed by the combined morbidity-mortality rate observed since the time of the procedure and up to one-year follow-up. For safety, primary analyses were performed on intent-to-treat population (attempted coils procedure) and all adverse events have been reviewed by an independent Data Safety Monitoring Board. For efficacy, primary analyses were performed on the per-protocol population (patients treated with more than 70% of Trufill coils and not retreated during the follow-up period) and an independent core laboratory evaluated angiographic results. Results At one-year post-procedure, neurologic impairment was observed in 6.5% (95% confidence interval: 3.5–11.8) of the patients, and 2.6% (95% confidence interval: 1.0–6.8) had a permanent neurological deterioration. Three deaths were observed, unrelated to the procedure or coils. At one year, complete occlusion was seen in 52 aneurysms (54.2%), neck remnant in 28 aneurysms (29.2%), and aneurysm remnant in 16 aneurysms (16.7%). During the one-year follow-up, the overall incidence of recurrence was 30.2% with a mean interval of 13.8 ± 4.5 months and the retreatment for major recanalization was needed in nine patients (6.3%). Conclusions The TRULINE study confirms that endovascular coiling with Trufill DCS Orbit and Orbit Galaxy detachable coils is safe and effective.
Trends Analysis of rhBMP Utilization in Single-Level Posterior Lumbar Interbody Fusion in the United States
Authors: Lao Lifeng , Cohen Jeremiah R. , Buser Zorica , Brodke Darrel S. , Youssef Jim A. , Park Jong-Beom , Yoon S. Tim , Wang Jeffrey C. , Meisel Hans-Joerg 
Published: September 2017

Study Design: Retrospective study. Objectives: Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used in spinal fusion surgery, but there is little information on rhBMP-2 utilization in single-level posterior lumbar interbody fusion (PLIF). The purpose of our study was to evaluate the trends and demographics of rhBMP-2 utilization in single-level PLIF. Methods: Patients who underwent single-level PLIF from 2005 to 2011 were identified by searching ICD-9 diagnosis and procedure codes in the PearlDiver Patient Records Database, a national database of orthopedic insurance records. The year of procedure, age, gender, and region of the United States were recorded for each patient. Results were reported for each variable as the incidence of procedures identified per 100 000 patients searched in the database. Results: A total of 2735 patients had single-level PLIF. The average rate of single-level PLIF with rhBMP-2 maintained at a relatively stable level (28% to 31%) from 2005 to 2009, but decreased in 2010 (9.9%) and 2011 (11.8%). The overall incidence of single-level PLIF without rhBMP-2 (0.68 cases per 100 000 patients) was statistically higher ( P < .01) compared to single-level PLIF with rhBMP-2 (0.21 cases per 100 000 patients). The average rate of single-level PLIF with rhBMP-2 utilization was the highest in West (30.1%), followed by Midwest (26.9%), South (20.5%), and Northeast (17.8%). The highest incidence of single-level PLIF with rhBMP-2 was observed in the age group <65 years (0.3 per 100 000 patients). Conclusions: To our knowledge, this is the first study to report on the demographics associated with rhBMP-2 use in single-level PLIF. There was a 3-fold increase in the rate of PLIF without rhBMP-2 compared to PLIF with rhBMP-2, with both procedures being mainly done in patients less than 65 years of age.
The Influence of National Health Insurance on Medication Adherence Among Outpatient Type 2 Diabetics in Southwest Nigeria
Authors: Ajibola Saka S , Timothy Fajemirokun O 
Published: September 2017

Purpose: Medication adherence (MA) is a challenge among patients with chronic diseases worldwide. Little has been reported on the influence of National Health Insurance Scheme (NHIS) on MA among diabetic patients in Nigeria. Objective: To assess the influence of NHIS on MA among outpatient type 2 diabetics in 2 public secondary health facilities in Southwest Nigeria. Method: A cross-sectional study involving 110 consecutively selected outpatient type 2 diabetics (insured, n = 42; uninsured, n = 68) was carried out. The patients’ perceptions of care and the influence of drug cost on MA between the insured and uninsured were compared. The patients’ perceptions of care were assessed using a 25-item pretested questionnaire. The MA was measured using the Morisky MA-8 scale. The use of oral antidiabetic drugs (OADs) was evaluated using a medical chart review. Information about patients’ sociodemographics, year of diagnosis, comorbidities, and types of OADs prescribed was retrieved from the medical records. Descriptive statistics were used for data presentation. A Pearson χ2 was used for test of associations. P values < .05 were considered significant. Results: Majority of the respondents (68 [61.8%]) were uninsured. The insured and the uninsured patients differed in their perceptions of the adequacy of time used by pharmacists for medication counseling ( P < .0005). The MA between the groups also differs ( P = .0002). The monthly drug cost for OADs was significantly associated with MA ( P = .037). Conclusion: The study concluded that the NHIS may positively influence MA among diabetic patients. The drug cost may have contributed significantly to the difference in MA between the groups. More time should be devoted to the counseling of the uninsured patients.
Triage of Women Testing Positive With the careHPV Test on Self-Collected Vaginal Samples for Cervical Cancer Screening in a Low-Resource Setting
Authors: Poli Usha Rani , Gowrishankar Swarnalata , Swain Meenakshi , Jeronimo Jose 
Published: September 2017

Purpose Human papillomavirus (HPV) DNA screening reduces cervical cancer incidence and mortality in low-resource settings. Self-collected vaginal samples tested with affordable HPV tests such as careHPV can increase the rate of screening in resource-constrained settings. We report the role of visual inspection with acetic acid (VIA) as a triage test for women testing positive with the careHPV test on self-collected vaginal samples. Methods As part of a multicountry demonstration study, 5,207 women 30 to 49 years of age were recruited from urban slums to undergo four cervical screening tests using the careHPV test on self-collected vaginal samples, provider-collected cervical samples, the Papanicolaou test, and VIA. All women who tested positive for any of the screening tests were evaluated with colposcopy and guided biopsies, followed by treatment if any cervical lesions were detected. The data from the 377 women who tested positive for HPV in the self-collected vaginal samples were also analyzed to assess the performance of VIA, conventional cytology, and colposcopy, as triage tests in the detection of cervical cancer and precancerous lesions. Results Nineteen percent of women who tested positive for vaginal HPV (V-HPV) also tested positive with the VIA test; cervical intraepithelial neoplasia 2+ lesions were detected in 58% of these women. In the 30 % of the women who tested positive for V-HPV with cytology triage, cervical intraepithelial neoplasia 2+ lesions were detected in 80% of these women. The colposcopy referrals for women who tested positive for V-HPV were reduced from 7.6% to 1.5% by VIA triage, and to 2.3% by cytology triage. Although the sensitivity was reduced, the positive predictive value improved after triage with VIA and cytology. Conclusion This study reflects the optimal role of VIA triaging for treatment selection of lesions among those who test positive for V-HPV in screen and treat screening programs that use an HPV test in low-resource settings.
Clinical Heterogeneity and Phenotypic Expansion of NaPi-IIa–Associated Disease
Authors: Demir Korcan , Yıldız Melek , Bahat Hilla , Goldman Michael , Hassan Nisreen , Tzur Shay , Ofir Ayala , Magen Daniella 
Published: September 2017

AbstractContextNaPi-IIa, encoded by SLC34A1, is a key phosphate transporter in the mammalian proximal tubule and plays a cardinal role in renal phosphate handling. NaPi-IIa impairment has been linked to various overlapping clinical syndromes, including hypophosphatemic nephrolithiasis with osteoporosis, renal Fanconi syndrome with chronic kidney disease, and, most recently, idiopathic infantile hypercalcemia and nephrocalcinosis.ObjectivesWe studied the molecular basis of idiopathic infantile hypercalcemia with partial proximal tubulopathy in two apparently unrelated patients of Israeli and Turkish descent.DesignGenetic analysis in two affected children and their close relatives was performed using whole-exome sequencing, followed by in vitro localization and trafficking analysis of mutant NaPi-IIa.ResultsMutation and haplotype analyses in both patients revealed a previously described homozygous loss-of-function inserted duplication (p.I154_V160dup) in NaPi-IIa, which is inherited identical-by-descent from a common ancestor. The shared mutation was originally reported by our team in two adult siblings with renal Fanconi syndrome, hypophosphatemic bone disease, and progressive renal failure who are family members of one of the infants reported herein. In vitro localization assays and biochemical analysis of p.I154_V160dup and of additional NaPi-IIa mutants harboring a trafficking defect indicate aberrant retention at the endoplasmic reticulum in an immature and underglycosylated state, leading to premature proteasomal degradation.ConclusionsOur findings expand the phenotypic spectrum of NaPi-IIa disruption, reinforce its link with proximal tubular impairment, enable longitudinal study of the natural history of the disease, and shed light on cellular pathways associated with loss of function and impaired trafficking of NaPi-IIa mutants.
Five-year follow-up of a prospective randomised trial comparing ceramic-on-metal and metal-on-metal bearing surfaces in total hip arthroplasty
Authors: Schouten R. , Malone A. A. , Frampton C. M. , Tiffen C. , Hooper G. 
Published: September 2017

Aims The primary aim of this independent prospective randomised trial was to compare serum metal ion levels for ceramic-on-metal (CoM) and metal-on-metal (MoM) bearing surfaces in total hip arthroplasty (THA). Our one-year results demonstrated elevation in metal ion levels above baseline with no significant difference between the CoM and MoM groups. This paper reviews the five-year data. Patients and Methods The implants used in each patient differed only in respect to the type of femoral head (ceramic or metal). At five-year follow-up of the 83 enrolled patients, data from 67 (36 CoM, 31 MoM) was available for comparison. Results The mean serum cobalt (Co) and chromium (Cr) ion levels remained above baseline in both groups (CoM: Co 1.16 μg/l (0.41 to 14.67), Cr 1.05 μg/l (0.16 to 12.58); MoM: Co 2.93 μg/l (0.35 to 30.29), Cr 1.85 μg/l (0.36 to 17.00)) but the increase was significantly less in the CoM cohort (Co difference p = 0.001, Cr difference p = 0.002). These medium-term results, coupled with lower revision rates from national joint registries, suggest that the performance of CoM THA may be superior to that of MoM. Conclusion While both bearing combinations have since been withdrawn these results provide useful information for planning clinical surveillance of CoM THAs and warrants continued monitoring. Cite this article: Bone Joint J 2017;99-B:1298–1303.
Do varus or valgus outliers have higher forces in the medial or lateral compartments than those which are in-range after a kinematically aligned total knee arthroplasty?
Authors: Shelton T. J. , Nedopil A. J. , Howell S. M. , Hull M. L. 
Published: September 2017

Aims The aims of this study were to determine the proportion of patients with outlier varus or valgus alignment in kinematically aligned total knee arthroplasty (TKA), whether those with outlier varus or valgus alignment have higher forces in the medial or lateral compartments of the knee than those with in-range alignment and whether measurements of the alignment of the limb, knee and components predict compartment forces. Patients and Methods The intra-operative forces in the medial and lateral compartments were measured with an instrumented tibial insert in 67 patients who underwent a kinematically aligned TKA during passive movement. The mean of the forces at full extension, 45° and 90° of flexion determined the force in the medial and lateral compartments. Measurements of the alignment of the limb and the components included the hip-knee-ankle (HKA) angle, proximal medial tibial angle (PMTA), and distal lateral femoral angle (DLFA). Measurements of the alignment of the knee and the components included the tibiofemoral angle (TFA), tibial component angle (TCA) and femoral component angle (FCA). Alignment was measured on post-operative, non-weight-bearing anteroposterior (AP) scanograms and categorised as varus or valgus outlier or in-range in relation to mechanically aligned criteria. Results The proportion of patients with outlier varus or valgus alignment was 16%/24% for the HKA angle, 55%/0% for the PMTA, 0%/57% for the DLFA, 25%/12% for the TFA, 100%/0% for the TCA, and 0%/64% for the FCA. In general, the forces in the medial and lateral compartments of those with outlier alignment were not different from those with in-range alignment except for the TFA, in which patients with outlier varus alignment had a mean paradoxical force which was 6 lb higher in the lateral compartment than those with in-range alignment. None of the measurements of alignment of the limb, knee and components predicted the force in the medial or lateral compartment. Conclusion Although kinematically aligned TKA has a high proportion of varus or valgus outliers using mechanically aligned criteria, the intra-operative forces in the medial and lateral compartments of patients with outlier alignment were comparable with those with in-range alignment, with no evidence of overload of the medial or lateral compartment of the knee. Cite this article: Bone Joint J 2017;99-B:1319–28.
Charting public art – a quantitative and qualitative approach to understanding sustainable social influences of art in the public realm
Authors: Cartiere Cameron 
Published: September 2017

Abstract
As public art continues to serve as a cultural cornerstone in the regeneration strategies of urban areas across North America and the European Union, the need for quantitative data on the sustainable economic, environmental and social impacts to support the beneficial claims of art in the public realm is becoming increasingly imperative. While much has been written to explore the development and expansion of public art, particularly as an agent of urban change, little by way of substantive evidence exists to support the anecdotal evidence and qualitative observations that underlie the argument of public art as a sustainable vehicle for urban regeneration and social change. This article explores some of the assumptions regarding the long-term effects of public art in the urban environment and outlines the development of a multi-disciplinary project in Vancouver, British Columbia that is endeavouring to develop a series of socially engaged public art projects to lay the foundation for research that aims to garner valuable qualitative and quantitative data reflecting the influences of public art within Canadian urban society.
Gesture in poetry, movement and music: Approaching the total artwork through Sufism in Say I am You and Deniz Küstü (The Sea-Crossed Fisherman)
Authors: Ellison Michael 
Published: September 2017

Abstract
In this article I speak about my experience of the connective thread of the gesture, and how metaphors of gesture across disciplines underpin relationships between music, poetry and dance. I explore the notion that, if there is a unifying force in the creation of Art and uncovering of Consciousness, it lies in some kind of Ur-gesture – a gesture that exists before translation into a certain medium – behind the forms a craftsman of music, dance or words of obligation ‘reduces it’ to. Further, I compare Rumi’s ideas on sema to those behind Whitehouse’s notion of Authentic Movement, and justify my approach to the staging of Rumi and sema in the opera Say I am You: as though the Mevlevi sema formal ritual had never been codified. Finally, I explore ideas surrounding Ur-gesture in interview with the foremost modern dance choreographer in Turkey today, Zeynep Tanbay, while probing her process of choreographing Deniz Küstü, my second opera.
Transmodernity and the heart: The unique position of the semazen-artist
Authors: McClure Hannah 
Published: September 2017

Abstract
This article looks at Sufi whirling as both a sacred act and a purifying process that sorts, sifts and reconfigures the ego. The article highlights the necessity of our spiritual and religious practices to a transmodern effort. By a renegotiation of ritual, practice and doctrine, ingenious solutions for both personhood and collective thriving may arise. The semazen-artist, an initiate who walks in the worlds of both spiritual submission and commercial arts production, emerges at a moment in time to hold the past, literally within their body and living practice, while consciously engaging the present towards a reimagined universal reality.
Surgical treatment of osteonecrosis associated with bisphosphonates: a case report
Authors: Barin Luisa Machado , Pillusky Fernanda Maia , Barcelos Raquel Cristine Silva , Escobar Carlos Alberto Bazaglia , Danesi Cristiane Cademartori 
Published: September 2017

Bisphosphonates (BP) are routinely used in the management of metastatic bone diseases and malignancies neoplasms, but there is an adverse effect of their chronic use called bisphosphonate-related osteonecrosis of the jaw (BRONJ). Treatment for BRONJ is challenging and complex, as there is still no definitive treatment protocols and the various treatments described in the literature have success variables indexes. In this sense, this study aims to emphasize the responsibility of dentist about the knowledge of BRONJ and report a clinical case that the surgical therapy was the best treatment option. Male patient, sixty-nine years old, asked for dental care complaining about bone exposure. On the anamneses, he reported the use of BP due to cancer history. The intra oral examination revealed exposed bone in the lower right molar region extending to retromolar trigon region on lingual side. There was conservative treatment with antibiotic therapy and mouth rinses of chlorhexidine 0.12 %, but not obtaining success. Therefore, we opted for the surgical removal of necrotic bone area and the tooth involved. The postoperative was within normal standard. The knowledge of dentist about this pathology is essential to prevent, diagnose and treat this disease the most appropriate way. Although the treatment of BRONJ remains challenging and complex, surgical therapy is a treatment option for lesions in early clinical stages and resistant to conservative treatment, providing a better prognosis and quality of life for the patient. KeywordsBisphosphonate-associated osteonecrosis; Mandible; Oral surgical procedures.
Ohne Zivilgesellschaft wäre es nicht gegangen
Authors: Speth Rudolf 
Published: September 2017

Zusammenfassung
Seit 2014 wurden steigende Zahlen Geflüchteter auf die Kommunen in Deutschland verteilt. Der Beitrag untersucht die Zusammenarbeit von zivilgesellschaftlichen Helfer*innengruppen, Verwaltung und Wohlfahrtsverbänden in den Kommunen Starnberg, Mannheim und Berlin. Ergebnis ist eine – bis auf Berlin – erstaunliche Kultur der Kooperation. Die zivilgesellschaftlichen Helfer*innengruppen haben in der Nothilfe Aufgaben des Staates übernommen, weil dieser nicht schnell genug reagieren konnte. Die diesem Beitrag zugrundeliegenden Interviews wurden in der ersten Phase der Nothilfe – im ersten Quartal 2016 – geführt. Heute geht es in der zweiten Phase um die komplexere und länger dauernde Aufgabe der Integration. Kaum eine zivilgesellschaftliche Gruppe hat ihre Arbeit eingestellt, vielmehr haben sie sich transformiert und den neuen Anforderungen angepasst.
Herausforderungen in der ehrenamtlichen Flüchtlingsarbeit
Authors: Sauer Madeleine , Vey Judith 
Published: September 2017

ZusammenfassungAuf Basis einer qualitativen Kurzstudie zu Ehrenamt in der Flüchtlingshilfe in Brandenburg beleuchtet der Beitrag das Verhältnis zwischen Ehrenamtlichen und Geflüchteten. Im Zentrum steht dabei eine Analyse der Bedürfnisse von Bewohner*innen von Gemeinschaftsunterkünften und wie diese durch die Angebote von ehrenamtlichen Unterstützungsgruppen befriedigt werden. Darüber hinaus wird gefragt, wie sich der konkrete Kontakt zwischen Hilfegebenden und -empfangenden gestaltet und welche Herausforderungen damit verbunden sind.