bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis ofDICER1in familial and sporadic cases of Transposition of the Great Arteries
Authors: Sabbaghian Nelly , Digilio M. Cristina , Blue Gillian M , Winlaw David S. , Foulkes William D 
Published: April 2017

AbstractBackgroundDICER1plays a major role in development and in generating mature microRNAs that are important in gene expression. We screened forDICER1mutations in a family with DICER1 syndrome and we discovered a pathogenic mutation in a child with transposition of the great arteries (TGA). In view of a report linkingDICER1knock-out in murine cardiomyocytes to cardiac outflow defects, we investigated the involvement of DICER1 in TGA.FindingsWe screened 129 germline DNA samples from children with either sporadic or familial forms of TGA forDICER1mutations using a Fluidigm access array, followed by next-generation sequencing. We identified 16 previously reported variants (5 synonymous, 6 intronic, and 5 missense) and 2 novel variants (1 intronic and 1 missense). We did not find any apparent pathological mutation in our cohort.ConclusionHere we report thatDICER1mutations do not appear to play a major role in TGA.
Functional Implications of Disordered Terminal Regions ofMacrotyloma uniflorumBowman-Birk Inhibitors: A Molecular Dynamics Study
Authors: Acharya Abhishek 
Published: April 2017

AbstractBowman-Birk Inhibitors (BBI) – a class of serine protease inhibitors is of considerable interest due to their anti-inflammatory and anti-carcinogenic properties. Recent efforts have focused on understanding the structure and dynamics of these inhibitors, and the molecular mechanism behind its bioactive properties. BBI derived from Horsegram seeds is an interesting member of the class that exists as a number of isoforms that differ in length at the C- and N-terminal disordered regions. Interestingly, the length (or conversely, truncation) of the terminal regions affect whether the protein exists as a dimer or monomer. Here, we have investigated the mechanism of dimerization in Horsegram BBI. A recent study has proposed that the dimerization occur via a C-terminal hook that forms a salt bridge with the opposite monomer and is pivotal to the dimerization process. We have employed long computational simulation methods to predict the stability of the proposed C-terminal hook; we show that the terminal regions are highly disordered and the salt bridges are significantly solvent exposed. Further, using Hamiltonian replica exchange method, we have sought to obtain the conformational ensemble of the disordered terminal regions and have identified a conformational state that provides an interaction hot-spot that aids in the dimerization of HGI. Our analysis predicts an alternate model of dimerization that largely agrees with previous experimental studies and yet again, highlights the importance of intrinsically disordered region in tailoring the protein function.
Contextual leadership of a multi-partner approach to health care innovation
Authors: Meyer Ellenore , Scheepers Caren 
Published: April 2017

Subject area
Organisational behaviour; Leadership; Organisational development; Public–Private partnership; Health care management; Public health.

Study level/applicability
Masters students in Business Administration, Post Graduate Diploma, Clinical Training of Medical Professionals, Health Leadership Programme.

Case overview
Prof Jannie Hugo, the protagonist in the case, was considering his dilemma of aligning the multiple partners involved in public health care. A high level of collaboration was required of a multitude of stakeholders in developing the Daspoort clinic into a pilot site for the Tshwane district’s implementation of the National Health Insurance system. In addition, the re-engineering of primary health care with the focus on the patient and community orientated approach were launched on this site.

Expected learning outcomes
Gaining insight into international and national landscapes and principles of health care systems. Critically analyse the role of technology in delivering innovative health and social services. Present judgment of Prof Jannie Hugo’s contextual leadership effectiveness in enhancing collaboration between the multiple stakeholders and recommend next steps.

Supplementary materials
2 × DVDs on Vimeo, Slides and teaching plan with discussion or exam questions with model answers.

Subject code
CSS 7: Management Science.
Integrated marketing communication – from an instrumental to a customer-centric perspective
Authors: Bruhn Manfred , Schnebelen Stefanie 
Published: April 2017

Purpose
Despite decades of scientific and practical experience in the field of integrated marketing communication (IMC), little is known about the role of IMC in the era of new media. The purpose of the present paper is to undertake a first step to close this gap by proposing thought-provoking impulses for customer-centric IMC. This is done by discussing central premises of customer-centric IMC in terms of the changed conditions on the media markets, its challenges and principles and its implementation issues.

Design/methodology/approach
The paper provides a conceptual approach to customer-centric IMC by deriving new lines of thinking from a review of existing literature relating to the concept of IMC.

Findings
The paper positions customer-centric IMC as an important advancement of IMC. It shows that the most important new lines of thinking which could be adopted as strategic components of customer-centric IMC are relationship orientation, content orientation and process orientation. The paper thus suggests that customer-centric IMC is a balancing act between a company’s own branding activities and the integration of customer-centered issues.

Originality/value
The originality of this paper resides in a detailed conceptual discussion of new insights into a customer-centric IMC. In contrast to existing work on IMC, this paper threads together the existing perspectives on IMC (inside-out and outside-in) to highlight the potential role of IMC in the era of social media (customer-centric IMC) by adding an outside-out view to the concept of IMC.
Integrating identity, strategy and communications for trust, loyalty and commitment
Authors: Melewar T.C. , Foroudi Pantea , Gupta Suraksha , Kitchen Philip J. , Foroudi Mohammad M. 
Published: April 2017

PurposeThis paper aims to operationalise and juxtapose variables related to identity, strategy and communications, and then examine the impact of such integration on organisational stakeholders’ trust, loyalty and commitment by using commitment/trust theory.Design/methodology/approachThis research design utilises explanatory research at the preliminary stage, as informed by the literature and conceptual framework. The subsequent model was examined via a positivist survey carried out among stakeholders in high-end retail stores in London. Structural equation modelling (SEM) via AMOS was conducted to gain insight into the various relevant influences and relationships.FindingsThe results indicate that identity and strategy are key drivers of integrated corporate communication, and they serve to build stakeholder trust, loyalty and commitment.Originality/valueThe paper shows that while practitioners have indicated that integrated marketing communication is important for organisations, there are a few other areas of concern with regard to consequences related to trust, loyalty and commitment, especially in a retail context. This paper empirically examined relationships between these constructs by validating a conceptual model by using SEM.
Application of the RBF collocation method to transient coupled thermoelasticity
Authors: Mavrič Boštjan , Šarler Božidar 
Published: April 2017

Purpose
In this study, the authors aim to upgrade their previous developments of the local radial basis function collocation method (LRBFCM) for heat transfer, fluid flow, electromagnetic problems and linear thermoelasticity to dynamic-coupled thermoelasticity problems.

Design/methodology/approach
The authors solve a thermoelastic benchmark by considering a linear thermoelastic plate under thermal and pressure shock. Spatial discretization is performed by a local collocation with multi-quadrics augmented by monomials. The implicit Euler formula is used to perform the time stepping. The system of equations obtained from the formula is solved using a Newton–Raphson algorithm with GMRES to iteratively obtain the solution. The LRBFCM solution is compared with the reference finite-element method (FEM) solution and, in one case, with a solution obtained using the meshless local Petrov–Galerkin method.

Findings
The performance of the LRBFCM is found to be comparable to the FEM, with some differences near the tip of the shock front. The LRBFCM appears to converge to the mesh-converged solution more smoothly than the FEM. Also, the LRBFCM seems to perform better than the MLPG in the studied case.

Research limitations/implications
The performance of the LRBFCM near the tip of the shock front appears to be suboptimal because it does not capture the shock front as well as the FEM. With the exception of a solution obtained using the meshless local Petrov–Galerkin method, there is no other high-quality reference solution for the considered problem in the literature yet. In most cases, therefore, the authors are able to compare only two mesh-converged solutions obtained by the authors using two different discretization methods. The shock-capturing capabilities of the method should be studied in more detail.

Originality/value
For the first time, the LRBFCM has been applied to problems of coupled thermoelasticity.
Research on qualities of compact spun silk yarn
Authors: Liu Xinjin , Wang Xingfeng 
Published: April 2017

Purpose
Spun silk is one of the top grade textile materials, and its products have high added value and meet the needs of the market. However, the technology level and process design of silk spinning are still much lower than cotton spinning; especially singeing is applied on spun silk yarn, and generates waste materials. The purpose of this paper is to introduce a kind of pneumatic compact spinning, four-line compact spinning (FLCS), into silk spinning and study the corresponding spun yarn qualities.

Design/methodology/approach
First, taking the silk spinning frame FK501 as an example, the process of modification of FLCS is presented. Then, three kinds of spun silk yarns, 80 Nm (12.5tex), 100 Nm (10tex) and 120 Nm (8.3tex), are spun on the common silk spinning frame FK501 and the spinning frame modified with FLCS. The evenness, breaking strength and hairiness of spun yarns are tested and comparatively analyzed. After the ply yarn production, three singeing procedures should be applied on the ring ply yarns, while only two singeing procedures should be applied on the compact ply yarns, which is beneficial for material saving.

Findings
The results show that compared with ring spun silk yarns, the comprehensive quality of compact spun silk yarns is improved, especially the harmful long hairiness (=3 mm) of yarn. Compared with the single spun silk yarn, the comprehensive qualities of the ply yarn are improved; especially, the breaking strength of the ply yarns is two times larger than the single yarn. After singeing, the hairiness of the ply yarn is decreased greatly, and the evenness is also improved, while the strength is decreased. Compared with ring spun silk yarn, the singeing times of compact spun silk yarn can be decreased, and the gas consumption in each singeing is also decreased, which is beneficial for material saving.

Originality/value
In this paper, a kind of pneumatic compact spinning, FLCS, is introduced into the silk spinning. It is shown that compared with ring spun silk yarns, the comprehensive quality of compact spun silk yarns is improved, especially the harmful long hairiness (=3 mm) of yarn. After the ply yarn production, three singeing procedures should be applied on the ring ply yarns, while only two singeing procedures should be applied on the compact ply yarns, which is beneficial for material saving.
The effect of Islamic values on voluntary corporate governance disclosure
Authors: Albassam Waleed M. , Ntim Collins G. 
Published: April 2017

PurposeThe study aims to examine the effect of Islamic values on the extent of voluntary corporate governance (CG) disclosure. In addition, the authors investigate the effect of traditional ownership structure and CG mechanisms on the extent of voluntary CG disclosure.Design/methodology/approachThe authors distinctively construct Islamic values and voluntary CG disclosure indices using a sample of 75 Saudi-listed firms over a seven-year period in conducting multivariate regressions of the effect of Islamic values on the extent of voluntary CG disclosure. The analyses are robust to controlling for firm-level characteristics, fixed-effects, endogeneities and alternative measures.FindingsThe authors find that corporations that depict greater commitment towards incorporating Islamic values into their operations through high Islamic values disclosure index score engage in higher voluntary CG disclosures than those that are not. Additionally, the authors find that audit firm size, board size, government ownership, institutional ownership and the presence of a CG committee are positively associated with the level of voluntary CG disclosure, whereas block ownership is negatively associated with the extent of voluntary CG disclosure.Practical implicationsThe study has clear practical implications for future research, practice and broader society by demonstrating empirically that corporations that voluntarily incorporate Islamic values into their operations are more likely to be transparent about their CG practices and thereby providing new crucial insights on the effect of Islamic values on voluntary CG compliance and disclosure.Originality/valueThis is the first empirical attempt at explicitly examining the effect of Islamic values on the extent of voluntary CG disclosure. The authors also offer evidence on the effect of traditional CG and ownership structures on the extent of voluntary CG disclosure.
The effects of expertise and brand schematicity on the perceived importance of choice criteria: a Bordeaux wine investigation
Authors: Carsana Laurence , Jolibert Alain 
Published: April 2017

Purpose
The purpose of this research is to understand the effects of expertise and brand schematicity on the perceived importance of choice criteria in the context of purchasing red wine purchase.

Design/methodology/approach
Data were collected via an online survey of 307 French wine consumers. The interaction effects of expertise and brand schematicity on the importance assigned to choice criteria were then investigated.

Findings
First, the results show that commercial brand is more important for brand-schematic consumers (novice and expert) than for brand-aschematic (novice and expert) consumers. Second, to make their choice, brand-schematic consumers place a greater reliance on quality cues than brand-aschematic consumers, whether they are novices or experts. Third, brand-aschematic novice consumers are only interested in two quality cues [Appellation d'Origine Contrôlée (AOC) label and wine category], but French brand-schematic novice and brand-aschematic expert consumers look for five quality cues (AOC label, wine category, vintage, commercial brand and place of bottling). Fourth, brand-schematic expert consumers take into account all quality cues.

Practical implications
The individual characteristics of consumers, that is, level of expertise and schematicity, influence the importance assigned to the information contained on the label. Care should be taken when designing a wine label, especially when consumers make their purchases in supermarkets and have no opportunity to seek advice. To convince these customers, it is essential that the font and size of the label ensure that the AOC label, wine category, vintage, commercial brand and place of bottling can be easily read. Brand-schematic consumers are interested in many quality cues to make their choice, and therefore, such information should be available in supermarkets (e.g. flyers and posters). Managers should also focus on brand content strategy to influence and hit brand-aschematic consumers.

Originality/value
There has been little research on the effect of brand schematicity on the importance of choice criteria. The interaction of brand schematicity and degree of expertise regarding product category has not been previously studied in relation to wine selection. Brand schematicity may be used as a segmentation criterion by managers in communication campaigns and brand content strategies.
Consumer attitudes toward online video advertisement: YouTube as a platform
Authors: Yang Keng-Chieh , Huang Chia-Hui , Yang Conna , Yang Su Yu 
Published: April 2017

Purpose
Online video advertisement is a wide-ranging phenomenon on the internet that provides huge opportunities for business enterprises. The revenues of website service providers come primarily from advertisement. However, it is rare to find research focusing on consumer attitudes toward online video advertisement. This study aims to investigate consumer attitudes toward advertisement while they are watching online videos on YouTube.

Design/methodology/approach
The paper followed Brackett and Carr’s (2001) Web Advertising Attitudes Model and combined it with the theory of reasoned action (TRA) and the flow theory. This study investigates consideration of the factors affecting attitudes toward advertisement and the influence on shopping intention and purchase behavior.

Findings
The findings indicate that entertainment, informativeness, irritation and credibility have a shopping influence on purchase attitudes. Flow, on the other hand, does have an influence on shopping intention and purchase behavior. The discussion and conclusion have been further discussed.

Originality/value
This study provides a comprehensive model for online video advertisement. This model was based on Brackett and Carr’s model, combining the users and gratifications theory, TRA and flow theory to develop an online video advertisement model. Researchers can consider this model as a framework and use it to capture a more complete picture of the relevant phenomena in their works.
The dynamics of transmission and the dynamics of networks
Authors: Farine Damien 
Published: April 2017

A toy example depicted here highlighting the results of a study in this issue of theJournal of Animal Ecologythat investigates the impact of network dynamics on potential disease outbreaks. Infections (stars) that spread by contact only (left) reduce the predicted outbreak size compared to situations where individuals can become infected by moving through areas that previously contained infected individuals (right). This is potentially important in species where individuals, or in this case groups, have overlapping ranges (as depicted on the top right). Incorporating network dynamics that maintain information about the ordering of contacts (central blocks; including the ordering of spatial overlap as noted by the arrows that highlight the blue group arriving after the red group in top‐right of the figure) is important for capturing how a disease might not have the opportunity to spread to all individuals. By contrast, a static or ‘average’ network (lower blocks) does not capture any of these dynamics. Interestingly, although static networks generally predict larger outbreak sizes, the authors find that in cases when transmission probability is low, this prediction can switch as a result of changes in the estimated intensity of contacts among individuals. [Colour figure can be viewed atwileyonlinelibrary.com].In Focus: Springer, A., Kappeler, P.M. & Nunn, C.L. (2017) Dynamic vs. static social networks in models of parasite transmission: PredictingCryptosporidiumspread in wild lemurs.Journal of Animal Ecology,86, 419–433.The spread of disease or information through networks can be affected by several factors. Whether and how these factors are accounted for can fundamentally change the predicted impact of a spreading epidemic. Springer, Kappeler & Nunn (2017) investigate the role of different modes of transmission and network dynamics on the predicted size of a disease outbreak across several groups of Verreaux's sifakas, a group‐living species of lemur. While some factors, such as seasonality, led to consistent differences in the structure of social networks, using dynamic vs. static representations of networks generated differences in the predicted outbreak size of an emergent disease. These findings highlight some of the challenges associated with studying disease dynamics in animal populations, and the importance of continuing efforts to develop the network tools needed to study disease spread.
Benefits of the destinations, not costs of the journeys, shape partial migration patterns
Authors: Yackulic Charles B. , Blake Stephen , Bastille‐Rousseau Guillaume 
Published: April 2017

Summary

The reasons that lead some animals to seasonally migrate, and others to remain in the same area year‐round, are poorly understood. Associations between traits, such as body size, and migration provide clues. For example, larger species and individuals are more likely to migrate.

One explanation for this size bias in migration is that larger animals are capable of moving faster (movement hypothesis). However, body size is linked to many other biological processes. For instance, the energetic balances of larger animals are generally more sensitive to variation in food density because of body size effects on foraging and metabolism and this sensitivity could drive migratory decisions (forage hypothesis).

Identifying the primary selective forces that drive migration ultimately requires quantifying fitness impacts over the full annual migratory cycle. Here, we develop a full annual migratory cycle model from metabolic and foraging theory to compare the importance of the forage and movement hypotheses. We parameterize the model for Galapagos tortoises, which were recently discovered to be size‐dependent altitudinal migrants.

The model predicts phenomena not included in model development including maximum body sizes, the body size at which individuals begin to migrate, and the seasonal timing of migration and these predictions generally agree with available data. Scenarios strongly support the forage hypothesis over the movement hypothesis. Furthermore, male Galapagos tortoises on Santa Cruz Island would be unable to grow to their enormous sizes without access to both highlands and lowlands.

Whereas recent research has focused on links between traits and the migratory phases of the migratory cycle, we find that effects of body size on the non‐migratory phases are far more important determinants of the propensity to migrate. Larger animals are more sensitive to changing forage conditions than smaller animals with implications for maintenance of migration and body size in the face of environmental change.