bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zielartenkonzepte als Instrument für den strategischen Schutz und das Monitoring der Biodiversität in Großschutzgebieten
Authors: Jedicke Eckhard 
Published: November 2016

Due to its complexity biodiversity cannot be measured easily – its quantification requires the selection of species which represent biodiversity. The systematic and criteria-based selection of target species provides a pragmatic solution. These target species are representative for the biocoenoses in the characteristic types of biotopes and ecosystems within a planning area. This approach allows to qualitatively and quantitatively derive and justify aims of nature conservation, to use them as simple indicators e. g. to prove the sustainability of a certain land use or the success of conservation measures, and to publicly communicate conservation objectives. This can be particularly helpful in large protected areas since they have to fulfil certain aims of conservation and sustainability as large-scale sections of the landscape. This paper defines the term and the functions of target species with a particular focus on large protected areas. It describes the methodical approach to establish a concept of target species including the applicable criteria using the examples of the nature parks Spessart and Diemelsee. For the nature park Diemelsee a particular emphasis has been laid on plant and animal species reacting sensitively to climate change since they require specific protection. Another innovative approach describes the use of target species in the context of the marketing of organic products from biosphere reserves which verifiably improve biodiversity. The selection of the target species has to ensure that their spatial demands are compatible with the respective planning level. Then the target species can integrate the planning target of biodiversity in spatially relevant planning projects. An evaluation based on target species allows the early identification of possible conflict issues and their mastering in the course of the planning process. This can help to relieve, accelerate and even cheapen the later planning process.
Allergens and molecular diagnostics of shellfish allergy
Authors: Lopata Andreas L. , Kleine-Tebbe Jörg , Kamath Sandip D. 
Published: November 2016

Abstract
Shellfish belongs to “The Big 8” food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans. However, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca2+-binding protein. Other allergens include myosin light chain, troponin C, triosephosphate isomerase, and actin. This review summarizes the current advances on the molecular characterization of shellfish allergens, clinical cross-reactivity, and current diagnostic approaches for the management of this life-threatening disease.
Acute effects of methylphenidate on impulsivity and attentional behavior among adolescents comorbid for ADHD and conduct disorder
Authors: Dougherty Donald M. , Olvera Rene L. , Acheson Ashley , Hill‐Kapturczak Nathalie , Ryan Stacy R. , Mathias Charles W. 
Published: November 2016

ABSTRACTAdolescents with Attention Deficit Hyperactivity Disorder (ADHD) and Conduct Disorder (CD) experience deficits in neuropsychological measures of attention, inhibition, and reward processes. Methylphenidate treatment for ADHD and CD has acute effects on these processes. Some of these same aspects of performance are separately described in the Behavioral Model of Impulsivity, which uses a modified approach to measurement. This study characterized the acute effects of methylphenidate attention, initiation, inhibition, and reward processes described in this model of impulsivity. Thirty‐one adolescents from the United States of America with comorbid ADHD and CD completed measures of impulsivity (response initiation, response inhibition, and consequence) and attention following placebo, 20 mg, and 40 mg of a long‐acting dose of methylphenidate. Methylphenidate effects on attentional performance was more robust than on any of the measures of impulsivity. Adolescent performance from this behavioral perspective is interpreted in the context of divergence from previous neuropsychological tests of acute methylphenidate effects.
Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients
Authors: Li Yi‐Nan , Shapiro Bryan , Kim Jun Chul , Zhang Min , Porszasz Janos , Bross Rachelle , Feroze Usama , Upreti Rajeev , Martin David , Kalantar‐Zadeh Kamyar , Kopple Joel David 
Published: November 2016

AbstractObjectiveMaintenance hemodialysis (MHD) patients often have impaired quality of life (QOL), anxiety, depression, and reduced daily physical activity (DPA) and physical performance. The contributions of these latter factors to reduced QOL in MHD are poorly understood. We examined the association of QOL with anxiety, depression, DPA, and physical performance.MethodsSeventy‐two relatively healthy adult MHD patients, vintage ≥6 months, and 39 normals of similar age range and gender distribution were studied. QOL was assessed using the Kidney Disease Quality of Life‐Short Form (KDQOL‐SF). Anxiety and depression were each evaluated with two questionnaires. DPA and physical performance were assessed with a physical activity monitor, Human Activity Profile, and 6‐minute walk, sit‐to‐stand, and stair‐climbing tests.ResultsMost KDQOL components were reduced in MHD patients versus normals. KDQOL components in patients were commonly inversely correlated with measures of anxiety and depression (P < 0.05) and were more reduced in patients with both anxiety and depression. KDQOL was often impaired in patients with either anxiety or depression. However, most KDQOL scores did not differ between patients and normals without anxiety or depression. DPA, Human Activity Profile, and physical performance often correlated with KDQOL scores in adjusted models, but after further adjustment for anxiety and depression, DPA, Human Activity Profile, and physical performance correlated less frequently with KDQOL scores. This reduction in significant correlations after adjustment for anxiety and depression was particularly pronounced for the association between KDQOL and DPA.ConclusionIn relatively healthy MHD patients, KDQOL scores are usually decreased in those with anxiety and/or depression but are usually normal in those without anxiety or depression. Lower DPA in MHD patients with reduced KDQOL scores often appears to be associated with anxiety and depression. The relationship between QOL and physical performance appears to be less influenced by anxiety and/or depression. These data suggest that treatment of anxiety and depression in MHD patients may improve their QOL, DPA, and possibly physical performance.
Power in time: The influence of power posing on metaphoric perspectives on time
Authors: DUFFY SARAH E. , FEIST MICHELE I. 
Published: November 2016

abstractIn English, the Moving Ego metaphor conceptualizes the ego as moving forward through time and the Moving Time metaphor construes time as moving forward toward the ego. Recent research has provided evidence that people’s metaphorical perspectives on deictic time may be influenced by experiences—both spatial and non-spatial—that are connected to approach motivations (Moving Ego) and avoidance motivations (Moving Time). We extend this research further, asking whether there are differences in preferred temporal perspective between those who exhibit higher and lower degrees of power, as high power has been connected to approach motivations and low power, to avoidance motivations. Across two temporal tasks, participants in our study who adopted high-power poses demonstrated a greater preference for the Moving Ego perspective, compared to those adopting low-power poses. These results suggest an embodied connection between approach and avoidance motivations and the Moving Ego and Moving Time metaphors, respectively.
The ‘Voordelta’, the contiguous ebb-tidal deltas in the SW Netherlands: large-scale morphological changes and sediment budget 1965–2013; impacts of large-scale engineering
Authors: Elias Edwin P.L. , van der Spek Ad J.F. , Lazar Marian 
Published: November 2016

AbstractThe estuaries in the SW Netherlands, a series of distributaries of the rivers Rhine, Meuse and Scheldt known as the Dutch Delta, have been engineered to a large extent as part of the Delta Project. The Voordelta, a coalescing system of the ebb-tidal deltas of these estuaries, extendsc.10 km offshore and coversc.90 km of the coast. The complete or partial damming of the estuaries had an enormous impact on the ebb-tidal deltas. The strong reduction of the cross-shore directed tidal flow triggered a series of morphological changes that continue until today. This paper aims to give a concise overview of half a century of morphological changes and a sediment budget, both for the individual ebb-tidal deltas and the Voordelta as a whole, based on the analysis of a unique series of frequent bathymetric surveys. The well-monitored changes in the Voordelta, showing the differences in responses of the ebb-tidal deltas, provide clear insight into the underlying processes. Despite anthropogenic dominance, knowledge based on natural inlets can still explain the observed developments. Complete damming of the three northern estuaries Brielse Maas, Haringvliet and Grevelingen resulted in a regime shift, from mixed-energy to wave-dominated, and sediments are transported in landward and downdrift direction. This results in large morphodynamic changes – sediments are redistributed from the delta front landward – but small net volume changes – a 0.1–0.2 × 106m3a−1increase in volume over the period 1965–2010 – since the dams block sediment transport into the estuaries. Sediment volume losses of 106m3a−1are observed on the ebb-tidal delta of the partially closed Eastern Scheldt and still open Western Scheldt estuary. As a result of a reduction of the estuarine tide in the mouth of the Eastern Scheldt, the north–south-running North Sea tidal wave has gained impact on its ebb-tidal delta, which causes morphological adjustments and erosion of the Banjaard shoal area. Moreover, the Eastern Scheldt ebb-tidal delta delivers sediment to its neighbours. The stable ebb-tidal delta configuration in the Western Scheldt, despite major dredging activities, illustrates that these large inlet systems are robust and resilient to significant anthropogenic change, as long as the balance between the dominant hydrodynamic processes (tides and waves) does not alter significantly.
Paternal age at childbirth and eating disorders in offspring
Authors: Javaras K. N. , Rickert M. E. , Thornton L. M. , Peat C. M. , Baker J. H. , Birgegård A. , Norring C. , Landén M. , Almqvist C. , Larsson H. , Lichtenstein P. , Bulik C. M. , D'Onofrio B. M. 
Published: November 2016

BackgroundAdvanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age's relationship with eating disorders in offspring. In a large, population-based cohort, we examined the association between paternal age and offspring eating disorders, and whether that association remains after adjustment for potential confounders (e.g. parental education level) that may be related to late/early selection into fatherhood and to eating disorder incidence.MethodData for 2 276 809 individuals born in Sweden 1979–2001 were extracted from Swedish population and healthcare registers. The authors used Cox proportional hazards models to examine the effect of paternal age on the first incidence of healthcare-recorded anorexia nervosa (AN) and all eating disorders (AED) occurring 1987–2009. Models were adjusted for sex, birth order, maternal age at childbirth, and maternal and paternal covariates including country of birth, highest education level, and lifetime psychiatric and criminal history.ResultsEven after adjustment for covariates including maternal age, advanced paternal age was associated with increased risk, and younger paternal age with decreased risk, of AN and AED. For example, the fully adjusted hazard ratio for the 45+ years (v. the 25–29 years) paternal age category was 1.32 [95% confidence interval (CI) 1.14–1.53] for AN and 1.26 (95% CI 1.13–1.40) for AED.ConclusionsIn this large, population-based cohort, paternal age at childbirth was positively associated with eating disorders in offspring, even after adjustment for potential confounders. Future research should further explore potential explanations for the association, including de novo mutations in the paternal germline.
‘Writing to make ageing new’: Dutch poets' understandings of late-life creativity
Authors: SWINNEN AAGJE 
Published: November 2016

ABSTRACTThis article presents the results of a study that examines how older professional writers experience and understand creativity in later life. In psychological, humanities' and gerontological approaches to ageing and creativity, this question is still under-explored. The study's data-set consists of transcriptions of lengthy interviews conducted in spring 2015 with five Dutch poets over 65 who have achieved some eminence in the field. By means of interpretative phenomenological analysis, three superordinate and 12 subordinate themes came to the fore that offer an account of the ideas, thoughts and feelings characteristic of the way these writers perceive the later stages in their career. The first superordinate theme, Securing Sustainable Writing Practices, comprises the subordinate themes of maintaining continuity in writing approach; drawing on wealth of experience; emancipating from earlier literary conceptions; and reinventing oneself as artist throughout the years. The second superordinate theme, Negotiating the Literary Field, encompasses the following subordinate themes: challenges regarding finding or keeping a publisher in later life; developing self-acceptance and relativising literary awards; handling continuity of reception, or the way literary work is pigeonholed by critics; and staying visible in the literary scene. The third and final superordinate theme, Writing as Art of Living, refers to: not feeling old(er); writing as a practice of good living; writing as a way to recreate what is lost or unknown; and confronting cognitive decline. Together, these superordinate and subordinate themes diversify ideas of late-life creativity that are based on questionable generalising conceptualisations of the psychology of later life and artistic careers.
Aetiological characteristics of adult acute diarrhoea in a general hospital of Shanghai
Authors: ZHAO X. , NI B. , WANG Y. , SHEN X. , ZHANG C. , LIU J. , LI S. 
Published: November 2016

SUMMARYEpidemic surveillance is an effective means to determine the characteristics of acute diarrhoea and the benefits of disease control and prevention. The epidemiological, clinical, and aetiological data of adult (aged ⩾15 years) acute diarrhoea in a general hospital in Shanghai were collected and analysed. Out of 2430 acute diarrhoea patients, 162 subjects were sampled (sample ratio 15:1). The sampled subjects had an average age (±s.d.) of 44 ± 18 years; 142 (87·7%) had a history that indicated ingestion of contaminated food; and 40 (24·7%), 54 (33·3%), and 73 (45·1%) patients had diarrhoea that was attributed to viral, bacterial, and unknown aetiological origins respectively. Viral diarrhoea is mainly prevalent during the winter and spring months, while bacterial and diarrhoea of unknown aetiology occur mainly in the summer months. The average age of the unknown aetiology group (48 ± 19 years) was significantly older than that of the viral diarrhoea group (39 ± 16 years). The number of patients with vomiting in the viral group (30·6%) was significantly higher than that in the bacterial (17·1%) and unknown aetiology (8·2%) groups. Viral and bacterial infections are the main cause of acute diarrhoea in Shanghai. However, further effective technological means are needed to improve the surveillance, control, and prevention of acute diarrhoea.
Frenchil y aclefts, existential sentences and the Focus-Marking Hypothesis
Authors: KARSSENBERG LENA 
Published: November 2016

ABSTRACTThis article presents the results of a corpus analysis of the information structure properties ofil y aclefts (e.g.Il y a Claude qui chante‘There is Claude who is singing’ / ‘Claude is singing’). I will show thatil y aclefts and existential sentences introduced byil y acan express the same three information structure articulations. Furthermore, it will be argued thatil y aclefts and existential sentences function as focus markers, and that this hypothesis is further supported by psycholinguistic findings concerning constructions related toil y a.
Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis
Authors: Toot Sandeep , Swinson Tom , Devine Mike , Challis David , Orrell Martin 
Published: November 2016

ABSTRACTBackground:Up to half of people with dementia in high income countries live in nursing homes and more than two-thirds of care home residents have dementia. Fewer than half of these residents report good quality of life and most older people are anxious about the prospect of moving into a nursing home. Robust evidence is needed as to the causes of admission to nursing homes, particularly where these risk factors are modifiable.Methods:We conducted a systematic literature search to identify controlled comparison studies in which the primary outcome was admission to nursing home of older adults with dementia. Identified studies were assessed for validity and 26 (17 cohort and 9 case-control) were included. Qualitative and quantitative analyses were conducted, including meta-analysis of 15 studies.Results:Poorer cognition and behavioral and psychological symptoms of dementia (BPSD) were consistently associated with an increased risk of nursing home admission and most of our meta-analyses demonstrated impairments in activities of daily living as a significant risk. The effects of community support services were unclear, with both high and low levels of service use leading to nursing home placement. There was an association between caregiver burden and risk of institutionalization, but findings with regard to caregiver depression varied, as did physical health associations, with some studies showing an increased risk of nursing home placement following hip fracture, reduced mobility, and multiple comorbidities.Conclusion:We recommend focusing on cognitive enhancement strategies, assessment and management of BPSD, and carer education and support to delay nursing home placement.
The location choice of US foreign direct investment: how do institutions matter?
Authors: SEN KUNAL , SINHA CHAITALI 
Published: November 2016

AbstractWe look at the institutional determinants of both within- and across-country variations in US foreign direct investment (FDI) flows over time. The strength of our approach is that in contrast to the previous work that has focused on average FDI flows across countries, we are able to explain both the variations in FDI flowsacrossandwithincountries for a given year. Our core hypothesis is that in countries with high quality of contract enforcement, multinationals are more likely to invest in the industries, where by their very nature investments are relationship specific. Conversely, in countries with low quality of contract enforcement, multinationals are more likely to invest in industries where investments to a large degree are not relationship specific. Using-three dimensional panel data for US FDI flows to 50 countries and 6 sectors for the period 1984–2010, we find strong support for our hypothesis. Our findings suggest that countries that want to attract US FDI in sectors that are highly intensive in technology and institutions such as transportation and electronics should improve their property rights and contracting environment.
Freedom from community: Individual rights, group life, state authority and religious freedom under the Indian Constitution
Authors: BHATIA GAUTAM 
Published: November 2016

Abstract:The religious freedom clauses of the Indian Constitution attempt to mediate between the competing claims of individuals, religious groups and the state, in a manner that is born out of specific historical circumstances. This article examines the controversial questions of whether, and to what extent, the Constitution grants individuals (specifically, dissenters) rights against the religious communities to which they belong. Taking as its point of departure a landmark Supreme Court judgment that struck down an anti-excommunication law, the article argues that the Indian Constitution is committed to an ‘anti-exclusion principle’: that is, group rights and group integrity are guaranteed to the extent – and only to the extent – that religious groups do not block individuals’ access to the basic public goods required to sustain a dignified life. Moreover – and unlike most other Constitutions – an individual may vindicate this right directly against her community in a court of law, by invoking the Constitution. This remedy is justified both philosophically, and in the specific context of Indian history. In this manner, Indian constitutionalism offers a novel and innovative solution to the perennial problem of balancing individual rights to religious freedom against the claims of community.
Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis
Authors: Chu Qiaoqiao , Huang Hongbing , Huang Tiejun , Cao Li , Peng Lixia , Shi Simei , Zheng Lisheng , Xu Liang , Zhang Shijun , Huang Jialing , Li Xinjian , Qian Chaonan , Huang Bijun 
Published: November 2016

AbstractSerglycin is a proteoglycan that was first found to be secreted by hematopoietic cells. As an extracellular matrix (ECM) component, serglycin promotes nasopharyngeal carcinoma (NPC) metastasis and serves as an independent, unfavorable NPC prognostic indicator. The detailed mechanism underlying the roles of serglycin in cancer progression remains to be clarified. Here, we report that serglycin knockdown in NPC cells inhibited cell sphere formation and tumor seeding abilities. Serglycin downregulation enhanced high-metastasis NPC cell sensitivity to chemotherapy. It has been reported that serglycin is a novel ligand for the stem cell marker CD44. Interestingly, we found a positive correlation between serglycin expression and CD44 in nasopharyngeal tissues and NPC cell lines. Further study revealed that CD44 was an ERK-dependent downstream effector of serglycin signaling, and serglycin activated the MAPK/β-catenin axis to induce CD44 receptor expression in a positive feedback loop. Taken together, our novel findings suggest that ECM serglycin upregulated CD44 receptor expression to maintain NPC stemness by interacting with CD44 and activating the MAPK/β-catenin pathway, resulting in NPC cell chemoresistance. These findings suggest that the intervention of serglycin/CD44 axis and downstream signaling pathway is a rational strategy for targeting NPC cancer stem cell therapy.