bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling
Authors: Harston George W.J. , Okell Thomas W. , Sheerin Fintan , Schulz Ursula , Mathieson Phil , Reckless Ian , Shah Kunal , Ford Gary A. , Chappell Michael A. , Jezzard Peter , Kennedy James 
Published: November 2016

Background and Purpose—
Perfusion-weighted imaging is used to select patients with acute ischemic stroke for intervention, but knowledge of cerebral perfusion can also inform the understanding of ischemic injury. Arterial spin labeling allows repeated measurement of absolute cerebral blood flow (CBF) without the need for exogenous contrast. The aim of this study was to explore the relationship between dynamic CBF and tissue outcome in the month after stroke onset.

Methods—
Patients with nonlacunar ischemic stroke underwent ≤5 repeated magnetic resonance imaging scans at presentation, 2 hours, 1 day, 1 week, and 1 month. Imaging included vessel-encoded pseudocontinuous arterial spin labeling using multiple postlabeling delays to quantify CBF in gray matter regions of interest. Receiver–operator characteristic curves were used to predict tissue outcome using CBF. Repeatability was assessed in 6 healthy volunteers and compared with contralateral regions of patients. Diffusion-weighted and T2-weighted fluid attenuated inversion recovery imaging were used to define tissue outcome.

Results—

Forty patients were included. In contralateral regions of patients, there was significant variation of CBF between individuals, but not between scan times (mean±SD: 53±42 mL/100 g/min). Within ischemic regions, mean CBF was lowest in ischemic core (17±23 mL/100 g/min), followed by regions of early (21±26 mL/100 g/min) and late infarct growth (25±35 mL/100 g/min; ANOVA
P
<0.0001). Between patients, there was marked overlap in presenting and serial CBF values.

Conclusions—
Knowledge of perfusion dynamics partially explained tissue fate. Factors such as metabolism and tissue susceptibility are also likely to influence tissue outcome.
Factors Influencing Likelihood of Voice Therapy Attendance: Report from the CHEER Network
Authors: Misono Stephanie , Marmor Schelomo , Roy Nelson , Mau Ted , Cohen Seth M. 
Published: November 2016

ObjectiveTo identify factors associated with the likelihood of attending voice therapy among patients referred for it in the CHEER (Creating Healthcare Excellence through Education and Research) practice‐based research network infrastructure.Study DesignProspectively enrolled cross‐sectional study.SettingCHEER network of community and academic sites.MethodsData were collected on patient‐reported demographics, voice‐related diagnoses, voice‐related handicap (Voice Handicap Index–10), likelihood of attending voice therapy (VT), and opinions on factors influencing likelihood of attending VT. The relationships between patient characteristics/opinions and likelihood of attending VT were investigated.ResultsA total of 170 patients with various voice‐related diagnoses reported receiving a recommendation for VT. Of those, 85% indicated that they were likely to attend it, regardless of voice‐related handicap severity. The most common factors influencing likelihood of VT attendance were insurance/copay, relief that it was not cancer, and travel. Those who were not likely to attend VT identified, as important factors, unclear potential improvement, not understanding the purpose of therapy, and concern that it would be too hard. In multivariate analysis, factors associated with greater likelihood of attending VT included shorter travel distance, age (40‐59 years), and being seen in an academic practice.ConclusionsMost patients reported plans to attend VT as recommended. Patients who intended to attend VT reported different considerations in their decision making from those who did not plan to attend. These findings may inform patient counseling and efforts to increase access to voice care.
Withdrawals and Retirements in Professional Tennis Players
Authors: Hartwell Matthew J. , Fong Sandra M. , Colvin Alexis C. 
Published: November 2016

Background: Injuries and illnesses for professional tennis athletes disrupt training, competition, and progression in the sport and represent a major reason for athlete withdrawal or retirement from a tournament. Few descriptive epidemiological studies have focused on these trends in elite tennis athletes. Purpose: To examine the causes of professional tennis player withdrawal or retirement from United States Tennis Association (USTA) Pro Circuit tournaments during 2013. Study Design: Descriptive epidemiology study. Level of Evidence: Level 4. Methods: Tournament records from the 2013 USTA Pro Circuit season were retrospectively reviewed for incidences of injury and illness that resulted in athlete withdrawal from the tournament. Data were reported as incidence rates per 1000 match exposures and rate ratios. Results: There were 70 medical conditions over the course of 27 competitions (20,988 match exposures), for an overall incidence rate of 3.34 per 1000 match exposures. Women were more likely to injure themselves on clay courts compared with hard courts (rate ratio, 4.67; 95% confidence interval [CI], 1.41-19.85) and in the first half of the season compared with the second half (rate ratio, 3.95; 95% CI, 1.13-21.17). Men had a higher injury rate than women (rate ratio, 1.88; 95% CI, 1.17-3.63), and muscle-/tendon-related injuries were 6 times more likely than all other injuries (95% CI, 2.81-14.69). Conclusion: Women were more likely to experience an injury when playing on clay court surfaces, and they also experienced more injuries during the first half of the season. Injury rates for men often peaked during the months that players could qualify for Grand Slam competitions. There was a predominance of injuries in men compared with women.
Optimal Lateral Row Anchor Positioning in Posterior-Superior Transosseous Equivalent Rotator Cuff Repair
Authors: Zumstein Matthias A. , Raniga Sumit , Labrinidis Agatha , Eng Kevin , Bain Gregory I. , Moor Beat K. 
Published: November 2016

Background: The optimal placement of suture anchors in transosseous-equivalent (TOE) double-row rotator cuff repair remains controversial. Purpose: A 3-dimensional (3D) high-resolution micro–computed tomography (micro-CT) histomorphometric analysis of cadaveric proximal humeral greater tuberosities (GTs) was performed to guide optimal positioning of lateral row anchors in posterior-superior (infraspinatus and supraspinatus) TOE rotator cuff repair. Study Design: Descriptive laboratory study. Methods: Thirteen fresh-frozen human cadaveric proximal humeri underwent micro-CT analysis. The histomorphometric parameters analyzed in the standardized volumes of interest included cortical thickness, bone volume, and trabecular properties. Results: Analysis of the cortical thickness of the lateral rows demonstrated that the entire inferior-most lateral row, 15 to 21 mm from the summit of the GT, had the thickest cortical bone (mean, 0.79 mm; P = .0001), with the anterior-most part of the GT, 15 to 21 mm below its summit, having the greatest cortical thickness of 1.02 mm ( P = .008). There was a significantly greater bone volume (BV; posterior, 74.5 ± 27.4 mm3; middle, 55.8 ± 24.9 mm3; anterior, 56.9 ± 20.7 mm3; P = .001) and BV as a percentage of total tissue volume (BV/TV; posterior, 7.3% ± 2.7%, middle, 5.5% ± 2.4%; anterior, 5.6% ± 2.0%; P = .001) in the posterior third of the GT than in intermediate or anterior thirds. In terms of both BV and BV/TV, the juxta-articular medial row had the greatest value (BV, 87.3 ± 25.1 mm3; BV/TV, 8.6% ± 2.5%; P = .0001 for both) followed by the inferior-most lateral row 15 to 21 mm from the summit of the GT (BV, 62.0 ± 22.7 mm3; BV/TV, 6.1% ± 2.2%; P = .0001 for both). The juxta-articular medial row had the greatest value for both trabecular number (0.3 ± 0.06 mm–1; P = .0001) and thickness (0.3 ± 0.08 μm; P = .0001) with the lowest degree of trabecular separation (1.3 ± 0.4 μm; P = .0001). The structure model index (SMI) has been shown to strongly correlate with bone strength, and this was greatest at the inferior-most lateral row 15 to 21 mm from the summit of the GT (2.9 ± 0.9; P = .0001). Conclusion: The inferior-most lateral row, 15 to 21 mm from the tip of the GT, has good bone stock, the greatest cortical thickness, and the best SMI for lateral row anchor placement. The anterior-most part of the GT 15 to 21 mm below its summit had the greatest cortical thickness of all zones. The posterior third of the GT also has good bone stock parameters, second only to the medial row. The best site for lateral row cortical anchor placement is 15 to 21 mm below the summit of the GT. Clinical Relevance: Optimal lateral anchor positioning is 15 to 21 mm below the summit of the greater tuberosity in TOE.
An Ecological Study of Anterior Cruciate Ligament Reconstruction, Part 1
Authors: McGrath Timothy M. , Waddington Gordon , Scarvell Jennie M. , Ball Nick , Creer Rob , Woods Kevin , Smith Damian , Adams Roger 
Published: November 2016

Background: Additional high-quality prospective studies are needed to better define the objective criteria used in relation to return-to-sport decisions after synthetic (ligament advanced reinforcement system [LARS]) and autograft (hamstring tendon [2ST/2GR]) anterior cruciate ligament (ACL) reconstruction in active populations. Purpose: To prospectively investigate and describe the recovery of objective clinical outcomes after autograft (2ST/2GR) and synthetic (LARS) ACL reconstructions, as well as to investigate the relationship between these clinimetric test outcomes and return-to-sport activity (Tegner activity scale [TAS] score) at 12 and 24 months postoperatively. Study Design: Case series; Level of evidence, 4. Methods: A total of 64 patients who underwent ACL reconstruction (32 LARS, 32 2ST/2GR autograft) and 32 healthy reference participants were assessed for joint laxity (KT-1000 arthrometer), clinical outcome (2000 International Knee Documentation Committee [IKDC] knee examination), and activity (TAS score) preoperatively and at 12, 16, 20, and 24 weeks and 12 and 24 months postoperatively. Results: There was no significant correlation observed between clinical results using the 2000 IKDC knee examination and TAS score at 24 months ( rs = 0.188, P = .137), nor were results for side-to-side difference ( rs = 0.030, P = .814) or absolute KT-1000 arthrometer laxity of the surgical leg at 24 months postoperatively ( rs = 0.076, P = .553) correlated with return-to-sport activity. Nonetheless, return-to-sport rates within the surgical cohort were 81% at 12 months and 83% at 24 months, respectively. No statistically significant differences were observed between physiological laxity of the uninjured knee within the surgical group compared with healthy knees within the reference group ( P = .522). Conclusion: The results indicate that although relatively high levels of return-to-sport outcomes were achieved at 24 months compared with those previously reported in the literature, correlations between objective clinical tests and return-to-sport outcomes may not occur. Clinical outcome measures may provide suitable baseline information; however, the results of this study suggest that clinicians may need to place greater emphasis on other outcome measures when seeking to objectively promote safe return to sport.
Empirical Simulation of the I-E Curves of a H2/Air PEM Fuel Cell at Asymmetric Relative Humidity
Authors: Al-Odail Faisal Abdellatif , Saleh Mahmoud M , Ohsaka Takeo 
Published: November 2016

Abstract
The present work is dedicated to study the performance of H2/Air proton exchange membrane (PEM) fuel cells (FC) by using an empirical modeling and experimental results at symmetric and asymmetric relative humidity. The empirical modeling is presented by Kim’s equation which was used in simulating the performance of the H2/Air PEM FC and in fitting the experimental data at different operating conditions. The simulation of the cell performance helps to understand the impacts of different kinetics, ohmic and mass-transfer resistances on the I-E curves and hence on the performance of the FC. By fitting the experimental data with the theoretical calculations, it is possible to extract important kinetics, ohmic and mass-transfer parameters at different temperatures and at different symmetric and asymmetric relative humidity. Although the exact physical meanings of some fitting parameters are quite clear, others are not.
BgeeDB, an R package for retrieval of curated expression datasets and for gene list expression localization enrichment tests
Authors: Komljenovic Andrea , Roux Julien , Robinson-Rechavi Marc , Bastian Frederic B. 
Published: November 2016

BgeeDB is a collection of functions to import into R re-annotated, quality-controlled and reprocessed expression data available in the Bgee database. This includes data from thousands of wild-type healthy samples of multiple animal species, generated with different gene expression technologies (RNA-seq, Affymetrix microarrays, expressed sequence tags, andin situhybridizations). BgeeDB facilitates downstream analyses, such as gene expression analyses with other Bioconductor packages. Moreover, BgeeDB includes a new gene set enrichment test for preferred localization of expression of genes in anatomical structures (“TopAnat”). Along with the classical Gene Ontology enrichment test, this test provides a complementary way to interpret gene lists.Availability:http://www.bioconductor.org/packages/BgeeDB/
Current knowledge about electronic cigarettes
Authors: Cope Graham 
Published: November 2016

As electronic cigarette usage becomes more common, practice nurses need to fully understand the health implications of e-cigs before they can advise their patients, writes Dr Graham Cope The emergence and growth of electronic cigarette (e-cig) usage has been one of the most significant changes to public health in recent times. The public are increasingly aware of the harmful effects of smoking and as a consequence many are looking to alternative, ‘healthier’ forms of nicotine delivery, either to maintain their addiction or, in some cases, to stop their smoking habit. The evidence suggests that e-cigs are a ‘healthier’ form of nicotine delivery than conventional cigarettes, but there are chemicals produced by these devices, including nicotine that have significant effects on health, especially if used long-term.
Hodgkin lymphoma in adults
Authors: Perry Margaret 
Published: November 2016

Hodgkin lymphoma is a rare blood cancer with a non-specific set of symptoms common to other illnesses. But with early diagnosis the prognosis for patients is good. This article looks at its symptoms, treatments and aftercare. By Margaret Perry Hodgkin lymphoma is a rare type of cancer of the blood. This article – the second of a three-part series, the first looked at Non-Hodgkin lymphoma – gives an overview of Hodgkin lymphoma, its diagnosis treatment management and prognosis. With an early diagnosis, Hodgkin's is one of the more easily cured cancers, and this article aims to enhance the knowledge of nurses about this rare condition and increase their confidence to instigate earlier diagnosis and treatment.
Issues and Challenges in Diagnostic Sequencing for Inherited Cardiac Conditions
Authors: Walsh Roddy , Cook Stuart A 
Published: November 2016

Abstract

BACKGROUND
Inherited cardiac conditions are a relatively common group of Mendelian diseases associated with ill health and death, often in the young. Research into the genetic causes of these conditions has enabled confirmatory and predictive diagnostic sequencing to become an integral part of the clinical management of inherited cardiomyopathies, arrhythmias, aortopathies, and dyslipidemias.

CONTENT
Currently, the principle benefit of clinical genetic testing is the cascade screening of family members of patients with a pathogenic variant, enabling targeted follow up of presymptomatic genotype-positive individuals and discharge of genotype-negative individuals to health. For the affected proband, diagnostic sequencing can also be useful in discriminating inherited disease from alternative diagnoses, directing treatment, and for molecular autopsy in cases of sudden unexplained death. Advances in sequencing technology have expanded testing panels for inherited cardiac conditions and driven down costs, further improving the cost-effectiveness of genetic testing. However, this expanded testing requires great rigor in the identification of pathogenic variants, with domain-specific knowledge required for variant interpretation.

SUMMARY
Diagnostic sequencing has the potential to become an integral part of the clinical management of patients with inherited cardiac conditions. However, to move beyond just confirmatory and predictive testing, a much greater understanding is needed of the genetic basis of these conditions, the role of the environment, and the underlying disease mechanisms. With this additional information it is likely that genetic testing will increasingly be used for stratified and preventative strategies in the era of genomic medicine.
Wirtschaftskrisen und Krisendiskurse: Vorwort der Herausgeber
Authors: Rossfeld Roman , Köhler Ingo 
Published: November 2016

Abstract
This volume examines the evolution of political, economic and media crisis discourses and semantics between the 18th century and the present. In the battle for opinion leadership, politicians, economists and the media frequently offer differing explanations and interpretations of economic crises. The metaphors used to describe such events can shape or even determine the dramaturgy and development of economic crises. The significance of the rhetorics of economics for the development of collective models or the behaviour of the various players involved in or affected by the crisis is an aspect that has not previously been examined. This volume makes a case for a stronger integration of cultural history and the history of knowledge in the analysis of economic crises in the 19th and 20th centuries. The focus is on the linguistic representation and construction of economic knowledge and the historical analysis of the complex relationship between economic crises and the rhetorics of economics.
Politik als Krankheit
Authors: Scholl Stefan 
Published: November 2016

Abstract
The article investigates the ways in which organic-medical metaphors were used to set the boundary of discourse between the economy and politics. The successful establishment of organic-medical metaphors for the economy is mainly explained by their connectivity to different political views. Concepts such as ‘Wirtschaftsleben’ or perceptions of the economy as an ‘organism’ laid the foundation for diagnosing sick or healthy conditions. From the end of the 19th to beyond the mid-20th century typical statements illustrate that the use of such metaphors supported the naturalization and stabilization of the boundary-setting discourse, insofar as it seemed natural that the relation between the two spheres should be formulated in terms of health and disease. Within liberal economic discourse in particular, politics was on the one hand targeted as a potential cause for economic disease, while on the other, it was claimed that politics had the task of keeping economic forces healthy.
Das Chaos beseitigen
Authors: Bemmann Martin 
Published: November 2016

Abstract
When in 1948 the United Nations’ Food and Agriculture Organization began to publish internationally comparable and reliable statistics on the global forestry and timber industry, it could rely on infrastructure and methods developed and established during the 1920s and 1930s as well as on personnel with experience of more than a decade. The article focuses on the actors involved and their motivation to develop and establish such international statistics. Given the frequent characterisation of the League of Nations’ Economic and Financial Organisation (EFO) as “path-breaking” and “pioneering” in statistical matters, this article then examines the EFO’s actual participation in the international standardisation of economic statistics. It is argued that its efforts in this field should be seen in a more differentiated way. EFO certainly became an indispensable player in the international standardisation of economic statistics. However, it neither defined the pace nor the direction of the process in every case. Instead, it rather had an accelerating effect on already existing efforts and served as a coordinating centre for a huge number of international organisations and actors involved in the standardisation process.
Zur Bedeutung nationalsozialistischer Statistiken und Statistiker nach dem Krieg
Authors: Fremdling Rainer 
Published: November 2016

Abstract
After the war, NS-statistics were put to manifold uses. Indeed, the industrial census of 1936 served both as a benchmark for the restrictions on German production imposed by the allied powers and as an indispensable input for the introduction of the planned economy in East Germany. In addition the NS-statisticians involved were also considered indispensable for interpreting and implementing these statistics.
In order to assess the economic effects of allied bombing during the war, John Kenneth Galbraith oversaw the Overall Economic Effects Division of the United States Strategic Bombing Survey. Wagenführ and other German statisticians were interrogated in order to elucidate the statistical files of Speer’s Planning Office (Planungsamt), the command centre of the German war economy. As the chief statistician in Speer’s Ministry for Armaments, Wagenführ had been in charge of the statistical information system for running the war economy.
The article focuses on a recently detected file on the kidnapping of Rolf Wagenführ by US-officers from Berlin to Bad Homburg in the summer of 1945. At that time, Wagenführ was working for the central command of the Soviet military administration of Germany. I found the report on the kidnapping and the ensuing interrogation which Wagenführ wrote for his Soviet command officer. It is part of the archival files of the German Democratic Republic hosted by the German Federal Archive (Bundesarchiv) in Berlin-Lichterfelde.
The article here concludes with both a brief presentation of those German production statistics (Statistische Schnellberichte) which had been compiled on a monthly basis for the inner political circle around Hitler during the war, and with some results from the USSBS.
Generalized sensitivity functions for multiple output systems
Authors: Kappel Franz , Munir Mohammad 
Published: November 2016

AbstractThe main purpose of this paper is to introduce the concept of generalized sensitivity matrices extending the usual concept of generalized sensitivity functions. We consider systems with finitely many measurable outputs, because this case occurs frequently. It is demonstrated that the generalized sensitivity matrix can be interpreted as the Jacobian of the estimated parameters with respect to the nominal parameter vector. This interpretation is supported by numerical results for two examples, the Verhulst–Pearl logistic growth model, which as been used frequently in the context of generalized sensitivity functions, and the so-called minimal model for the intravenous glucose tolerance test, which represents a system with two measurable outputs. Furthermore, we discuss the implications of linear behavior of the generalized sensitivity matrix at large sampling times for identifiability of system parameters.
Crystal structure of 1-methyl-3-[((naphthalen-2-ylsulfonyl)oxy)imino]indolin-2-one, C19H14N2O4S
Authors: El-Faham Ayman , Khattab Sherine N. , Ghabbour Hazem A. 
Published: November 2016

Abstract
C19H14N2O4S, triclinic, P1̅, a = 5.9059(2) Å, b = 10.1508(5) Å, c = 13.6286(6) Å, α = 88.499(2)°, β = 88.744(2))°, γ = 84.569(2)°, V = 812.93(6) Å3, Z = 2, Rgt(F
2) = 0.058, wR(F
2) = 0.147, T = 100 K.