bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggregation‐Induced Emission and Sensing Characteristics of Triarylborane–Oligothiophene–Dicyanovinyl Triads
Authors: Kumar George Rajendra , Sarkar Samir Kumar , Thilagar Pakkirisamy 
Published: September 2016

AbstractThe design, synthesis and aggregation‐induced emission properties of a new series of triarylborane–oligothiophene–dicyanovinyl (DCV) conjugates 4–6 (A–D–A’ type molecular configuration) are reported. The optical properties of 4–6 can be modulated by judiciously varying the number of thiophene units between electron deficient boryl and dicyanovinyl units. Compound 6 with terthiophene spacer showed highly red‐shifted absorption and emission compared to 5 and 4 with bithiophene and monothiophene spacers, respectively. Compounds 5 and 6 show aggregation‐induced emission enhancement in water/THF mixtures. Compounds 5 and 6 also showed solvent viscosity dependent emission characteristics. All the three compounds show distinct optical responses for small anions such as fluoride and cyanide. Filter paper strips coated with compounds 5 and 6 can detect F− and CN− in aqueous media with different colorimetric responses.
ChemInform Abstract: Composite Icosahedron/Cube Endohedral Clusters in Rh2Cd15.
Authors: Xie Weiwei , Liu Minhao , Wang Zhijun , Ong Nai‐Phuan , Cava Robert J. 
Published: September 2016

AbstractSingle crystals of Rh2Cd15 are obtained in the initial search for M3Cd97 (M: transition metals) by heating the elements in the respective proportions (evacuated silica tubes, 600 °C, 1 d; cooling to 400 °C at a rate of 3 °C/h, 2 d).
ChemInform Abstract: Copper Selenidophosphates Cu4P2Se6, Cu4P3Se4, Cu4P4Se3, and CuP2Se, Featuring Zero‐, One‐, and Two‐Dimensional Anions.
Authors: Kuhn Alexander , Schoop Leslie M. , Eger Roland , Moudrakovski Igor , Schwarzmueller Stefan , Duppel Viola , Kremer Reinhard K. , Oeckler Oliver , Lotsch Bettina V. 
Published: September 2016

AbstractFive new compounds in the Cu—P—Se system are prepared from stoichiometric mixtures of the elements (550‐1000 °C, 1‐3 d).
ChemInform Abstract: High Ionic Conductivity with Low Degradation in A‐Site Strontium‐Doped Nonstoichiometric Sodium Bismuth Titanate Perovskite.
Authors: Yang Fan , Zhang Huairuo , Li Linhao , Reaney Ian M. , Sinclair Derek C. 
Published: September 2016

AbstractPolycrystalline phase‐pure Na0.5Bi0.47Sr0.02TiO2.975 is prepared by calcination of appropriate amounts of Na2CO3, Bi2O3, TiO2, and SrCO3 (800 °C, 2 h) followed by ball milling, pelletizing, and final annealing (1150 °C, 2 h).
ChemInform Abstract: The Structure Feature of Layered M1/3TiNbO5 (M: Fe, Ce) and Their Photocatalytic Oxidization Performance for Ethyl Mercaptan.
Authors: Dong Rui , Wang Yuan , Wang Ningning , Xu Lei , He Jie , Wu Shanshan , Lan Yunxiang , Hu Jinsong 
Published: September 2016

AbstractLayered photocatalytic M1/3TiNbO5 (M: Fe, Ce) is prepared by ion‐exchange of KTiNbO5 with 2 M M(NO3)3 (96 h).
ChemInform Abstract: Synthesis, Crystal Structure, Theoretical, and Resistivity Study of BaUSe3.
Authors: Prakash Jai , Tarasenko Maria S. , Mesbah Adel , Lebegue Sebastien , Malliakas Christos D. , Ibers James A. 
Published: September 2016

AbstractSingle crystals of BaUSe3 are prepared by heating stoichiometric amounts of the elements in a CsCl flux (evacuated quartz tubes, 1.
ChemInform Abstract: Sr2OsO5 and Sr7Os4O19, Two Structurally Related, Mott Insulating Osmates(VI) Exhibiting Substantially Reduced Spin Paramagnetic Response.
Authors: Mohitkar Shrikant A. , Schnelle Walter , Felser Claudia , Jansen Martin 
Published: September 2016

AbstractThe title compounds are prepared by solid state reactions of SrO2, OsO2, and Os metal (quartz ampule, 1073 K, 24 h) and characterized by powder XRD and magnetic measurements.
ChemInform Abstract: Ring‐Opening Reaction of Aziridines with Amines under the Influence of Dimethyl Sulfoxide.
Authors: Isobe Toshihiro , Oriyama Takeshi 
Published: September 2016

AbstractThis 1,2‐diamine synthesis can be performed with a wide range of aziridines and amines under mild conditions and does not require a metal reagent.
ChemInform Abstract: Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides.
Authors: Pace Vittorio , de la Vega‐Hernandez Karen , Urban Ernst , Langer Thierry 
Published: September 2016

AbstractAddition of the in situ generated Schwartz reagent to isocyanates constitutes a chemoselective, high‐yielding, and versatile approach to the synthesis of functionalized formamides.
ChemInform Abstract: Directed, Regiocontrolled Hydroamination of Unactivated Alkenes via Protodepalladation.
Authors: Gurak John A. Jr. , Yang Kin S. , Liu Zhen , Engle Keary M. 
Published: September 2016

AbstractA hydroamination of terminal and internal olefins affords γ‐amino acids in good yields with high regioselectivity, utilizing an 8‐aminoquinoline directing group.
ChemInform Abstract: A General Alkyl‐Alkyl Cross‐Coupling Enabled by Redox‐Active Esters and Alkylzinc Reagents.
Authors: Qin Tian , Cornella Josep , Li Chao , Malins Lara R. , Edwards Jacob T. , Kawamura Shuhei , Maxwell Brad D. , Eastgate Martin D. , Baran Phil S. 
Published: September 2016

AbstractThe C—C bond formation proceeds in the presence of a simple, inexpensive nickel catalyst and the method exhibits a remarkably broad scope across a range of substrates (<70 examples).
ChemInform Abstract: Magnetic Iron Oxide Nanoparticles—N‐Heterocyclic Carbene—Palladium(II): A New, Efficient and Robust Recyclable Catalyst for Mizoroki—Heck and Suzuki—Miyaura Coupling Reactions.
Authors: Hajipour Abdol R. , Tadayoni Nayereh S. , Khorsandi Zahra 
Published: September 2016

AbstractThe novel catalyst can be recovered and reused at least ten times without significant loss of activity.
ChemInform Abstract: An Efficient Protocol for Formylation of Amines Using Carbon Dioxide and PMHS under Transition‐Metal‐Free Conditions.
Authors: Nale Deepak B. , Bhanage Bhalchandra M. 
Published: September 2016

AbstractPrimary, secondary, and aromatic amines are utilized in formylation reactions using a highly efficient, green, and simple base catalytic system.
ChemInform Abstract: Selective Hydrogenation of Nitriles to Secondary Amines Catalyzed by a Pyridyl‐Functionalized and Alkenyl‐Tethered NHC—Ru(II) Complex.
Authors: Saha Sayantani , Kaur Mandeep , Singh Kuldeep , Bera Jitendra K. 
Published: September 2016

AbstractThe Ru‐catalyzed hydrogenation of nitriles leads to symmetrical secondary amines, whilst the reaction in the presence of amines (III) gives rise to unsymmetrical secondary amines.
ChemInform Abstract: 1‐(1‐Alkylsulfonic)‐3‐methylimidazolium Chloride as a Reusable Broensted Acid Catalyst for the Regioselective Azidolysis of Epoxides under Solvent‐Free Conditions.
Authors: Rezayati Sobhan , Nezhad Eshagh Rezaee , Hajinasiri Rahimeh 
Published: September 2016

Abstract1‐(1‐Propylsulfonic)‐3‐methylimidazolium chloride is used as a green and reusable catalyst for the regioselective ring‐opening reactions of various epoxides with sodium azide to afford the corresponding β‐azido alcohols in excellent yields within short reaction times under mild conditions.
ChemInform Abstract: Palladium‐Catalyzed Carboxylation of Activated Vinylcyclopropanes with CO2.
Authors: Mita Tsuyoshi , Tanaka Hiroyuki , Higuchi Yuki , Sato Yoshihiro 
Published: September 2016

AbstractThe intermediate in this reaction seems to be a nucleophilic η1‐allylethylpalladium species, arising from π‐allylpalladium and ZnEt2 (umpolung).
ChemInform Abstract: Cinchona Alkaloid and Di‐tert‐butyldicarbonate—DMAP Promoted Efficient Synthesis of (E)‐Nitroolefins.
Authors: Poomathi Nataraj , Perumal Paramasivan T. 
Published: September 2016

AbstractVarious β‐nitroolefins are prepared from arylidinemalononitriles and nitromethane with total E‐selectivity under metal‐free reaction conditions.
ChemInform Abstract: A Cu‐Catalyzed Four‐Component Cascade Reaction to Construct β‐Ester‐γ‐amino Ketones.
Authors: Ling Jiayue , Zhang Jie , Zhao Yanwei , Xu Yudong , Wang Hanghang , Lv Yuanzheng , Ji Meishan , Ma Liang , Ma Meihua , Wan Xiaobing 
Published: September 2016

AbstractThe title ketones are prepared from readily available styrenes, diazo compounds, and amines.
ChemInform Abstract: Highly Efficient and Reusable Polystyrene‐Supported Copper(II) Catalytic System for S‐Arylation of Potassium Thiocyanate by Aryl Halides in Water.
Authors: Hajipour Abdol R. , Jajarmi Saeideh 
Published: September 2016

AbstractA range of arylthioethers is synthesized.
ChemInform Abstract: TBAI—HBr System Mediated Generation of Various Thioethers with Benzenesulfonyl Chlorides in PEG400.
Authors: Wang Dingyi , Guo Shengmei , Zhang Rongxing , Lin Sen , Yan Zhaohua 
Published: September 2016

AbstractAryl sulfides are prepared by direct sulfenylation of various compounds such as phenols, indoles, pyrazolones, and related heteroarenes in good to excellent yields.
ChemInform Abstract: Synthesis of 2H‐Azirines by Iridium‐Catalyzed Decarboxylative Ring Contraction of Isoxazol‐5(4H)‐ones
Authors: Okamoto Kazuhiro , Shimbayashi Takuya , Yoshida Masato , Nanya Atsushi , Ohe Kouichi 
Published: September 2016

Abstractunder phosphine‐free and environmentally benign conditions
ChemInform Abstract: Revisited Mechanistic Implications of the Joullie—Ugi Three‐Component Reaction.
Authors: Katsuyama Akira , Matsuda Akira , Ichikawa Satoshi 
Published: September 2016

AbstractThe Joullie—Ugi three‐component reaction proceeds in hexafluoro‐2‐propanol through SN1‐type mechanism to generate the trans‐isomer, whereas in toluene the cis‐isomer is generated selectively via a SN2‐type mechanism.
ChemInform Abstract: Cross‐Cycloaddition of Two Different Isocyanides: Chemoselective Heterodimerization and [3 + 2]‐Cyclization of 1,4‐Diazabutatriene.
Authors: Hu Zhongyan , Yuan Haiyan , Men Yang , Liu Qun , Zhang Jingping , Xu Xianxiu 
Published: September 2016

AbstractThe title reaction of isocyanochalcones with aromatic and aliphatic isonitriles produces 1,4‐diazabutatriene intermediates by a hetero isonitrile dimerization followed by intramolecular [3 + 3] cycloaddition.
ChemInform Abstract: AgX@carbon (X: Br and I) as Robust and Efficient Catalysts for the Reaction of Propargylic Alcohols and CO2 to Carbonates under Ambient Conditions.
Authors: Qiu Jikuan , Zhao Yuling , Wang Huiyong , Cui Guokai , Wang Jianji 
Published: September 2016

Abstractα‐Alkylidene cyclic carbonates are prepared in high yields using AgI supported on activated carbon as catalyst.
ChemInform Abstract: Synthesis of Substituted Pyrazole N‐Oxide and Pyrazole from Propargyl Amine.
Authors: Unnava Ramanjaneyulu , Saikia Anil K. 
Published: September 2016

AbstractPropargyl amine can react with NaNO2 in acetic acid using AgOTf as the catalyst to give pyrazole N‐oxides, which can be further converted to other pyrazole derivatives.
ChemInform Abstract: Synthesis of 2,4,5‐Trisubstituted Imidazoles over Reusable CoFe2O4 Nanoparticles: An Efficient and Green Sonochemical Process.
Authors: Eidi Esmaiel , Kassaee M. Z. , Nasresfahani Zahra 
Published: September 2016

AbstractThe catalyst can be reused for over five runs without significant loss of activity.
ChemInform Abstract: Asymmetric Dual Catalysis via Fragmentation of a Single Rhodium Precursor Complex.
Authors: Song Liangliang , Gong Lei , Meggers Eric 
Published: September 2016

AbstractA newly synthesized single rhodium complex is used as an efficient catalyst in the Michael reaction of 2‐acyl imidazoles with α,α‐disubstituted aldehydes.
ChemInform Abstract: NH‐Heterocyclic Aryliodonium Salts and Their Selective Conversion into N1‐Aryl‐5‐iodoimidazoles.
Authors: Wu Yichen , Izquierdo Susana , Vidossich Pietro , Lledos Agusti , Shafir Alexandr 
Published: September 2016

AbstractNew (NH‐imidazolyl)aryl iodonium acetates can be easily prepared from imidazole and aryliodonium diacetates and their Cu(II)‐catalyzed rearrangement is studied to provide a synthesis of N1‐aryl‐5‐iodoimidazoles.
ChemInform Abstract: A One‐Pot Tandem Approach for the Synthesis of 5‐(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides.
Authors: Vinay Kumar Koravangala , Swaroop Toreshettahally R. , Rajeev Narasimhamurthy , Vinayaka Ajjampura C. , Lingaraju Gejjalagere S. , Rangappa Kanchugarakoppal S. , Sadashiva Maralinganadoddi P. 
Published: September 2016

AbstractThe title oxazoles are prepared from (het)aryl methyl alcohols or benzyl bromides by a new modified van Leusen reaction under basic conditions.
ChemInform Abstract: The Annulation of Vinyl Azides with Potassium Ethyl Xanthogenate: A Straightforward Synthesis of Thiazole‐2(3H)‐thiones.
Authors: Rajaguru Kandasamy , Mariappan Arumugam , Muthusubramanian Shanmugam , Bhuvanesh Nattamai 
Published: September 2016

AbstractThe title synthesis is a domino reaction including the Michael addition of xanthogenate to vinyl azide, nitrogen elimination, intramolecular nucleophilic addition‐elimination, and 1,3‐hydride shift.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Diastereo‐ and Enantioselective Mannich‐Type Reaction Between Enamides and Thiazolones.
Authors: Kikuchi Jun , Momiyama Norie , Terada Masahiro 
Published: September 2016

AbstractThe optically active thiazolone product (IIIa) undergoes a ring‐opening reaction upon treatment with benzylamine to afford α,β‐diamino amide (V) without loss of enantioselectivity.
ChemInform Abstract: A Multicomponent Reaction on a ′Free′ KCC‐1 Catalyst at Room Temperature under Solvent Free Conditions by Visible Light.
Authors: Sadeghzadeh Seyed Mohsen 
Published: September 2016

AbstractA green method for the preparation of triazoloindazoles by multicomponent reaction of dimedone, benzaldehydes, and phenylurazole using fibrous nanosilica (KCC‐1) as catalyst is developed.
ChemInform Abstract: Synthesis of Isochroman Derivatives via Oxa‐Pictet—Spengler Reaction of Vinylogous Esters.
Authors: Sarkar Sujit , Sultana Sabera , Indukuri Kiran , Unnava Ramanjaneyulu , Saikia Anil K. 
Published: September 2016

AbstractTrimethylsilyl triflate is efficiently used for the synthesis of isochromans via Pictet—Spengler type reaction of vinylogous esters in good yields.
ChemInform Abstract: Facile and Eco‐Friendly Synthesis of Chromeno[4,3‐b]pyrrol‐4(1H)‐one Derivatives Applying Magnetically Recoverable Nano Crystalline CuFe2O4 Involving a Domino Three‐Component Reaction in Aqueous Media.
Authors: Saha Moumita , Pradhan Koyel , Das Asish R. 
Published: September 2016

AbstractThe catalyst can be reused for at least six runs without significant loss of activity.
ChemInform Abstract: Copper‐Catalyzed Imino C—N Bond Formation with Aryl Boronic Acids under Aerobic Conditions.
Authors: Mandal Prashant S. , Kumar A. Vijay 
Published: September 2016

AbstractN‐arylated iminochromenes are prepared by ligand‐ and base‐free cross‐couplings of iminochromenes with arylboronic acids in moderate to good yields.
ChemInform Abstract: An Intramolecular Cycloaddition of Nitrones with Tethered Olefins: A Versatile Synthesis of Hexahydro‐3H‐xantheno[1,2‐c]isoxazoles.
Authors: Rao Y. Jayaprakash , Reddy E. Pravardhan , Sridhar B. , Lakshmi J. K. , Reddy B. V. Subba 
Published: September 2016

AbstractNitrones generated in situ from aldehydes (I) and hydroxylamines undergo intramolecular cycloaddition to give isoxazolines (II) and isoxazolidines (IV) with high diastereoselectivity.
ChemInform Abstract: The p‐Toluenesulfonic Acid Catalyzed Single Pot Synthesis of Tetracyclic 1,2‐Dihydroquinolines: A Metal Free Approach.
Authors: Hajare Anil K. , Jagdale Arun R. , Shenoy G. Gautham , Sinha Neelima 
Published: September 2016

AbstractA simple and efficient methodology for the synthesis of polysubstituted 1,2‐dihydroquinoline derivatives via a one‐pot tandem process is developed using Tos‐OH as catalyst.
ChemInform Abstract: Tetrahydroquinolines via Stereospecific [3 + 3]‐Annulation of Donor—Acceptor Cyclopropanes with Nitrosoarenes.
Authors: Das Saikat , Chakrabarty Shyamal , Daniliuc Constantin G. , Studer Armido 
Published: September 2016

AbstractThe [3+3]‐annulation of donor‐acceptor cyclopropanes with nitrosoarenes under the influence of MgBr2 as a Lewis acid proceeds stereospecifically and offers a novel approach to C‐8 brominated tetrahydroquinolines.
ChemInform Abstract: Palladium‐Catalyzed Radical Cascade Difluoroalkylation/Cyclization of Acrylamide with Ethyl Difluorobromoacetate.
Authors: Xia Xiao‐Feng , Zhu Su‐Li , Li Yuan , Wang Haijun 
Published: September 2016

AbstractThis reaction delivered a new method for synthesis of difluoromethylated isoquinoline‐1,3‐dione.
ChemInform Abstract: Cy‐SaBOX/Copper(II)‐Catalyzed Highly Diastereo‐ and Enantioselective Synthesis of Bicyclic N,O Acetals.
Authors: Liu Qiong‐Jie , Wang Lijia , Kang Qi‐Kai , Zhang X. Peter , Tang Yong 
Published: September 2016

AbstractThe products are obtained with excellent stereoselectivities.
ChemInform Abstract: Synthesis of 1,5‐Disubstituted Tetrazoles Containing a Fragment of the Anticancer Drug Imatinib via a Microwave‐Assisted Ugi‐Azide Reaction.
Authors: Cortes‐Garcia Carlos J. , Islas‐Jacome Alejandro , Renteria‐Gomez Angel , Gamez‐Montano Rocio 
Published: September 2016

AbstractThe title tetrazoles (30 examples) may exhibit cytotoxicity and/or tyrosine‐kinase inhibitory properties because of their structural similarities with potent cancer drugs such as imatinib.
ChemInform Abstract: A Novel Copper‐Catalyzed Preparation of Pyrido[1,2‐a]pyrimidine Derivatives
Authors: Mahdavi Mohammad , Fazli Estabragh Roxana , Moghimi Setareh , Sayahi Mohammad Hosein , Shafiee Abbas , Foroumadi Alireza 
Published: September 2016

Abstractstarting from aminopropynylpyridinium bromide derivatives and aromatic sulfonyl azides involving a novel application of ketenimines
ChemInform Abstract: Stereoselective Nucleophilc Substitution of α‐Bromo Tertiary Amides for Asymmetric Synthesis of Highly Substituted 2,5‐Diketopiperazines.
Authors: Lee Myung‐su , Kim Yongtae , Youk Eunjee , Park Yong Sun 
Published: September 2016

AbstractTri‐ and tetrasubstituted diketopiperazines are synthesized by cyclization reaction of α‐bromo tertiary acetamides bearing a sterically bulky N‐alkyl group in high stereoselectivity.
ChemInform Abstract: Synthesis of Cyclooctatetraenes Through a Palladium‐Catalyzed Cascade Reaction.
Authors: Blouin Sarah , Gandon Vincent , Blond Gaelle , Suffert Jean 
Published: September 2016

AbstractA unique pathway for the synthesis of fully substituted cyclooctatetraenes is developed using Pd‐catalyzed cyclization of trialkynyl derivatives in the presence of tributyltin organyls.
ChemInform Abstract: An Unusual 1(10→19)abeo Steroid from a Jellyfish‐Derived Fungus.
Authors: Kim Eun La , Li Jian Lin , Hong Jongki , Yoon Won Duk , Kim Hyung Sik , Liu Yonghong , Wei Xiaoyi , Jung Jee H. 
Published: September 2016

Abstractisolation and structure elucidation of the structurally unique C25 steroid, phomarol (I)
ChemInform Abstract: New Antiinflammatory Sterols from a Gorgonian Pinnigorgia sp.
Authors: Su Yin‐Di , Cheng Ching‐Hsiao , Wen Zhi‐Hong , Wu Yang‐Chang , Sung Ping‐Jyun 
Published: September 2016

AbstractTwo new sterols (I) and (II) are isolated from a gorgonian Pinnigorgia sp.
ChemInform Abstract: Palcernuine, the First [5/6/6/6]‐Cernuane‐Type Alkaloid from Palhinhaea cernua f. sikkimensis
Authors: Tang Yu , Xiong Juan , Zou Yike , Nay Bastien , Wang Li‐Jun , Hu Jin‐Feng 
Published: September 2016

Abstractisolation and structure elucidation of palcernuine (I)
ChemInform Abstract: Progress on the Synthesis and Catalytic and anti‐Migration Properties of Ferrocene‐Based Burning Rate Catalysts
Authors: Zhou Weidong , Wang Li , Yu Haojie , Tong Rongbai , Chen Qing , Wang Junhua , Yang Xianpeng , Zain‐ul‐Abdin Xianpeng , Saleem Muhammad 
Published: September 2016

AbstractReview: 93 refs.
ChemInform Abstract: Synthesis of Multisubstituted Olefins Through Regio‐ and Stereoselective Addition of Interelement Compounds Having B—Si, B—B, and Cl—S Bonds to Alkynes, and Subsequent Cross‐Couplings
Authors: Iwasaki Masayuki , Nishihara Yasushi 
Published: September 2016

AbstractReview: 123 refs.
ChemInform Abstract: Odyssey in Polyphasic Catalysis by Metal Nanoparticles
Authors: Denicourt‐Nowicki Audrey , Roucoux Alain 
Published: September 2016

AbstractReview: use of metallic nanoparticles, either in water or liquids, as relevant and retrievable catalysts in various reactions (hydrogenation, C—C coupling, asymmetric transformations, oxidation...); 110 refs.
ChemInform Abstract: Catalytic Efficiency of Primary β‐Amino Alcohols and Their Derivatives in Organocatalysis
Authors: Reddy Ummareddy Venkata Subba , Chennapuram Madhu , Seki Chigusa , Kwon Eunsang , Okuyama Yuko , Nakano Hiroto 
Published: September 2016

AbstractReview: [81 refs.
15‐Methylene‐Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia
Authors: Gunasekara Dilini C. , Zheng Mary M. , Mojtahed Tara , Woods James R. , Fandy Tamer E. , Riofski Mark V. , Glackin Carlotta A. , Hassan Hazem E. , Kirshner Julia , Colby David A. 
Published: September 2016

AbstractRecent studies suggest that leukemia stem cells (LSCs) play a critical role in the initiation, propagation, and relapse of leukemia. Herein we show that (−)‐15‐methylene‐eburnamonine, a derivative of the alkaloid (−)‐eburnamonine, is cytotoxic against acute and chronic lymphocytic leukemias (ALL and CLL) and acute myelogenous leukemia (AML). The agent also decreases primary LSC frequency in vitro. The cytotoxic effects appear to be mediated via the oxidative stress pathways. Furthermore, we show that the compound kills AML, ALL, and CLL stem cells. By the use of a novel humanized bone marrow murine model of leukemia (huBM/NSG), it was found to decrease progenitor cell engraftment.
Utilization of surgical treatment for local and locoregional esophageal cancer: Analysis of the National Cancer Data Base
Authors: Taylor Lauren J. , Greenberg Caprice C. , Lidor Anne O. , Leverson Glen E. , Maloney James D. , Macke Ryan A. 
Published: September 2016

BACKGROUNDPrevious studies have suggested that esophagectomy is severely underused for patients with resectable esophageal cancer. The recent expansion of endoscopic local therapies, advances in surgical techniques, and improved postoperative outcomes have changed the therapeutic landscape. The impact of these developments and evolving treatment guidelines on national practice patterns is unknown.METHODSPatients diagnosed with clinical stage 0 to III esophageal cancer were identified from the National Cancer Database (2004‐2013). The receipt of potentially curative surgical treatment over time was analyzed, and multivariate logistic regression was used to identify factors associated with surgical treatment.RESULTSThe analysis included 52,122 patients. From 2004 to 2013, the overall rate of potentially curative surgical treatment increased from 36.4% to 47.4% (P < .001). For stage 0 disease, the receipt of esophagectomy decreased from 23.8% to 17.9% (P < .001), whereas the use of local therapies increased from 34.3% to 58.8% (P < .001). The use of surgical treatment increased from 43.4% to 61.8% (P < .001), from 36.1% to 45.0% (P < .001), and from 30.8% to 38.6% (P < .001) for patients with stage I, II, and III disease, respectively. In the multivariate analysis, divergent practice patterns and adherence to national guidelines were noted between academic and community facilities.CONCLUSIONSThe use of potentially curative surgical treatment has increased for patients with stage 0 to III esophageal cancer. The expansion of local therapies has driven increased rates of surgical treatment for early‐stage disease. Although the increased use of esophagectomy for more advanced disease is encouraging, significant variation persists at the patient and facility levels. Cancer 2017;123:410–419. © 2016 American Cancer Society.