bluuebunny/crossref_metadata_2025_split huggingface dataset:
Susceptibility to oral squamous cell carcinoma: correlation with variants of CYP1A1-MspI, GSTT1, GSTM1, ALDH2, EC-SOD and Lifestyle factors
Authors: Dong T-T , Wang L-J , Liu L-Z , Ma S-N 
Published: March 2017

Abstract
In order to investigate the association between polymorphisms in genes encoding metabolizing enzymes (CYP1A1-MspI, EC-SOD (extracellular superoxide dismutase), GSTT1, GSTM1, ALDH2), cigarette and alcohol consumption, and the risk of oral squamous cell carcinoma, we conducted a prospective case-control study comprised of 750 individuals with oral squamous cell carcinoma (OSCC) and 750 healthy individuals. Data about smoking and drinking habits were collected along with other demographic and clinical information. Peripheral blood samples were collected for DNA extraction, and polymerase chain reaction (PCR) and PCR-RFLP (restriction fragment length polymorphism) were used to determine genotypes of CYP1A1, EC-SOD, GSTT1, GSTM1, ALDH2. The results showed that smoking and alcohol consumption were significantly more common among patients than controls (p <0.05). There were significant differences in the genotype distribution for each locus between groups, with the CYP1A1 (m2/ m2), EC-SOD (C/G), GSTT1 [–], GSTM1 [–] and ALDH2 (non G/G) genotypes being more common among patients (p <0.05). Furthermore, the majority of patients had at least two or more variant genotypes, while controls had one or no variant genotype (p <0.05). Finally, multiple variant genotypes combined with smoking, drinking, or both smoking and drinking significantly increased the risk of OSCC, with greater increase for heavier smoking/drinking. In brief, genetic polymorphism of CYP1A1, EC-SOD, GSTT1, GSTM1, and ALDH2 and smoking and drinking history are closely associated with susceptibility to OSCC.
Deliberate Metaphor Theory: Basic assumptions, main tenets, urgent issues
Authors: Steen Gerard 
Published: March 2017

AbstractIn response to two recent publications about Deliberate Metaphor Theory (DMT) in this journal, I argue that DMT advances metaphor studies into a period with new and exciting research challenges and possibilities for application between various disciplines. I will first spell out my basic assumptions about eleven core concepts in all verbal metaphor research. Then I will present the main tenets of DMT about the difference between deliberate and non-deliberate metaphor. Finally I will briefly discuss which urgent issues still need to be addressed.
Platelet-rich fibrin (PRF) in implants dentistry in combination with new bone regenerative flapless technique: evolution of the technique and final results
Authors: Cortese Antonio , Pantaleo Giuseppe , Amato Massimo , Howard Candace M. , Pedicini Lorenzo , Claudio Pier Paolo 
Published: March 2017

Abstract
Most common techniques for alveolar bone augmentation are guided bone regeneration (GBR) and autologous bone grafting. GBR studies demonstrated long-term reabsorption using heterologous bone graft. A general consensus has been achieved in implant surgery for a minimal amount of 2 mm of healthy bone around the implant.
A current height loss of about 3-4 mm will result in proper deeper implant insertion when alveolar bone expansion is not planned because of the dome shape of the alveolar crest. To manage this situation a split crest technique has been proposed for alveolar bone expansion and the implants’ insertion in one stage surgery. Platelet-rich fibrin (PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration without inflammatory reactions, and may be used alone or in combination with bone grafts, promoting hemostasis, bone growth, and maturation.

Aim
The aim of this study was to demonstrate the clinical effectiveness of PRF combined with a new split crest flapless modified technique in 5 patients vs. 5 control patients.

Materials and methods
Ten patients with horizontal alveolar crests deficiency were treated in this study, divided into 2 groups: Group 1 (test) of 5 patients treated by the flapless split crest new procedure; Group 2 (control) of 5 patients treated by traditional technique with deeper insertion of smaller implants without split crest. The follow-up was performed with x-ray orthopantomography and intraoral radiographs at T0 (before surgery), T1 (operation time), T2 (3 months) and T3 (6 months) post-operation.

Results
All cases were successful; there were no problems at surgery and post-operative times. All implants succeeded osteointegration and all patients underwent uneventful prosthetic rehabilitation. Mean height bone loss was 1 mm, measured as bone-implant most coronal contact (Δ-BIC), and occurred at immediate T2 post-operative time (3 months). No alveolar bone height loss was detected at implant insertion time, which was instead identified in the control group because of deeper implant insertion.

Conclusion
This modified split crest technique combined with PRF appears to be reliable, safe, and to improve the clinical outcome of patients with horizontal alveolar crests deficiency compared to traditional implanting techniques by avoiding alveolar height-loss related to deeper insertion of smaller implants.
Comparing Performance During Morning vs. Afternoon Training Sessions in Intercollegiate Basketball Players
Authors: Heishman Aaron D. , Curtis Michael A. , Saliba Ethan N. , Hornett Robert J. , Malin Steven K. , Weltman Arthur L. 
Published: March 2017

Abstract
Heishman, AD, Curtis, MA, Saliba, EN, Hornett, RJ, Malin, SK, and Weltman, AL. Comparing performance during morning vs. afternoon training sessions in intercollegiate basketball players. J Strength Cond Res 31(6): 1557–1562, 2017—Time of day is a key factor that influences the optimization of athletic performance. Intercollegiate coaches oftentimes hold early morning strength training sessions for a variety of factors including convenience. However, few studies have specifically investigated the effect of early morning vs. late afternoon strength training on performance indices of fatigue. This is athletically important because circadian and/or ultradian rhythms and alterations in sleep patterns can affect training ability. Therefore, the purpose of the present study was to examine the effects of morning vs. afternoon strength training on an acute performance index of fatigue (countermovement jump height, CMJ), player readiness (Omegawave), and self-reported sleep quantity. We hypothesized that afternoon training sessions would be associated with increased levels of performance, readiness, and self-reported sleep. A retrospective analysis was performed on data collected over the course of the preseason on 10 elite National Collegiate Athletic Association Division 1 male basketball players. All basketball-related activities were performed in the afternoon with strength and conditioning activities performed either in the morning or in the afternoon. The average values for CMJ, power output (Power), self-reported sleep quantity (sleep), and player readiness were examined. When player load and duration were matched, CMJ (58.8 ± 1.3 vs. 61.9 ± 1.6 cm, p = 0.009), Power (6,378.0 ± 131.2 vs. 6,622.1 ± 172.0 W, p = 0.009), and self-reported sleep duration (6.6 ± 0.4 vs. 7.4 ± 0.25 p = 0.016) were significantly higher with afternoon strength and conditioning training, with no differences observed in player readiness values. We conclude that performance is suppressed with morning training and is associated with a decrease in self-reported quantity of sleep.
The Influence of Resistance Training Experience on the Between-Day Reliability of Commonly Used Strength Measures in Male Youth Athletes
Authors: Weakley Jonathon J.S. , Till Kevin , Darrall-Jones Joshua , Roe Gregory A.B. , Phibbs Padraic J. , Read Dale B. , Jones Ben L. 
Published: March 2017

Abstract
Weakley, JJS, Till, K, Darrall-Jones, J, Roe, GAB, Phibbs, PJ, Read, DB, and Jones, BL. The influence of resistance training experience on the between-day reliability of commonly used strength measures in male youth athletes. J Strength Cond Res 31(7): 2005–2010, 2017—The purpose of this study was to determine the between-day reliability of commonly used strength measures in male youth athletes while considering resistance training experience. Data were collected on 25 male athletes over 2 testing sessions, with 72 hours rest between, for the 3 repetition maximum (3RM) front squat, chin-up, and bench press. Subjects were initially categorized by resistance training experience (inexperienced; 6–12 months, experienced; >2 years). The assessment of the between-day reliability (coefficient of variation [CV%]) showed that the front squat (experienced: 2.90%; inexperienced: 1.90%), chin-up (experienced: 1.70%; inexperienced: 1.90%), and bench press (experienced: 4.50%; inexperienced: 2.40%) were all reliable measures of strength in both groups. Comparison between groups for the error of measurement for each exercise showed trivial differences. When both groups were combined, the CV% for the front squat, bench press, and chin-up were 2.50, 1.80, and 3.70%, respectively. This study provides scientists and practitioners with the between-day reliability reference data to determine real and practical changes for strength in male youth athletes with different resistance training experience. Furthermore, this study demonstrates that 3RM front squat, chin-up, and bench press are reliable exercises to quantify strength in male youth athletes.
Effect of Cold Water Immersion Performed on Successive Days on Physical Performance, Muscle Damage, and Inflammatory, Hormonal, and Oxidative Stress Markers in Volleyball Players
Authors: de Freitas Victor H. , Ramos Solange P. , Bara-Filho Maurício G. , Freitas Daniel G.S. , Coimbra Danilo R. , Cecchini Rubens , Guarnier Flávia A. , Nakamura Fábio Y. 
Published: March 2017

Abstract
de Freitas, VH, Ramos, SP, Bara-Filho, MG, Freitas, DGS, Coimbra, DR, Cecchini, R, Guarnier, FA, and Nakamura, FY. Effect of cold water immersion performed on successive days on physical performance, muscle damage, and inflammatory, hormonal, and oxidative stress markers in volleyball players. J Strength Cond Res 33(2): 502–513, 2019—The aim of this study was to investigate the effects of daily cold water immersion (CWI) on physical performance, muscle damage, and inflammatory, hormonal, and oxidative stress markers in volleyball. Six players were submitted to CWI and six players to a placebo, during 5 training days. Thigh circumference, squat jump, and agility were measured on the first, third, and sixth days. On the first and sixth days, blood and saliva were collected for analysis of oxidative stress, muscle damage, and inflammatory and hormonal levels. Muscle soreness and countermovement jump were quantified daily. The physical performance comparisons did not present differences and the only between group comparison with a large effect size (ES = −1.39) was in Δ% between day 1 and day 2 for countermovement jump. Delayed onset muscle soreness and creatine kinase increased in both groups and the ESs of between group comparisons of Δ% between moments were not more than moderate. Thigh circumference increased only in the placebo group (p = 0.04) and the ES of the between group comparisons of Δ% between moments was large (1.53). No differences were found in oxidative stress, or inflammatory markers. Cortisol decreased only in the CWI-group (p ≤ 0.05) and the ESs of the between group comparisons of Δ% between moments of the testosterone to cortisol ratio (−1.94) and insulin-like growth-1 (−1.34) were large. Despite the positive effects of daily CWI on muscle edema and hormonal status, the limited effects of CWI on performance, muscle damage, inflammation markers, and reactive oxygen species mediators signal the unimportance of the daily practice of this recovery method in volleyball players.
Perceived Exertion Is Affected by the Submaximal Set Configuration Used in Resistance Exercise
Authors: Mayo Xian , Iglesias-Soler Eliseo , Kingsley J. Derek 
Published: March 2017

Abstract
Mayo, X, Iglesias-Soler, E, and Kingsley, JD. Perceived exertion is affected by the submaximal set configuration used in resistance exercise. J Strength Cond Res 33(2): 426–432, 2019—Previously, perceived exertion in submaximal resistance exercise protocols was reported to be affected by the intensity of load followed by work-to-rest ratio. Nevertheless, the effect of set configuration, which entails the metabolic, hormonal, and neuromuscular implication of the session, is currently unknown, despite the fact that perceived exertion discriminates these differences. We aimed to analyze the effect of 3 submaximal set configurations on perceived exertion and their relationship with velocity as a mechanical measure of fatigue. Seventeen healthy subjects (23 ± 2 years) performed with the 10-repetition maximum load on the leg press (211 ± 45 kg) a total of 40 repetitions with 720 seconds of rest in 3 randomized experimental sessions with the same work-to-rest ratio. The sessions consisted of an interrepetition rest design performing individual repetitions, a cluster design performing groups of 4 repetitions, and a traditional design performing groups of 8 repetitions. At the end of the session, the nonparametric analysis of variance–type test revealed differences between protocols (p < 0.001), with lower values of perceived exertion in the interrepetition rest design in comparison with the cluster design (p = 0.003) and traditional design (p < 0.001). In addition, Spearman's rank correlations (p < 0.001) were observed for the interrepetition rest design (rho = −0.72) and traditional design (rho = −0.8) between perceived exertion and velocity. Our findings suggest that the submaximal set configuration is a determinant of perceived exertion by itself, and that perceived exertion represents similar mechanisms as velocity, such as fatigue and certain characteristics of the session and the individual.
Body Composition and Bone Mineral Density of Division 1 Collegiate Football Players: A Consortium of College Athlete Research Study
Authors: Bosch Tyler A. , Carbuhn Aaron F. , Stanforth Philip R. , Oliver Jonathan M. , Keller Kathryn A. , Dengel Donald R. 
Published: March 2017

Abstract
Bosch, TA, Carbuhn, AF, Stanforth, PR, Oliver, JM, Keller, KA, and Dengel, DR. Body composition and bone mineral density of Division 1 collegiate football players: a consortium of college athlete research study. J Strength Cond Res 33(5): 1339–1346, 2019—The purpose of this study was to generate normative data for total and regional body composition in Division 1 collegiate football players using dual-energy x-ray absorptiometry (DXA) and examine positional differences in total and regional measurements. Data were used from the Consortium of College Athlete Research (C-CAR) group. Four hundred sixty-seven players were included in this study. Height, body mass, total and regional fat mass, lean mass, and bone mineral density were measured in each athlete in the preseason (June–August). Players were categorized by their offensive or defensive position for comparisons. Linemen tended to have the higher fat and lean mass measures (p ≤ 0.05 for all) compared with other positions. Positions that mirror each other (e.g. linemen) had similar body composition and body ratios. All positions were classified as overweight or obese based on body mass index (BMI) (>25 kg·m−2), yet other than offensive and defensive linemen, all positions had healthy percent body fat (13–20%) and low visceral fat mass (<500 g). The data presented here provide normative positional data for total and regional fat mass, lean mass, and bone density in Division 1 collegiate football players. Player position had a significant effect on body composition measures and is likely associated with on-field positional requirements. From a player's health perspective, although all positions had relatively high BMI values, most positions had relatively low body fat and visceral fat, which is important for the health of players during and after their playing career. The increased accuracy and reliability of DXA provides greater information, regarding positional differences in college football players compared with other methods.
Physiological Factors Associated With Declining Repeated Sprint Performance in Hypoxia
Authors: Gatterer Hannes , Menz Verena , Untersteiner Christian , Klarod Kultida , Burtscher Martin 
Published: March 2017

Abstract
Gatterer, H, Menz, V, Untersteiner, C, Klarod, K, and Burtscher, M. Physiological factors associated with declining repeated sprint performance in hypoxia. J Strength Cond Res 33(1): 211–216, 2019—Performance loss in hypoxia might not only be caused by reduced oxygen availability, but might also be influenced by other factors, as for example, oxidative stress, perceived exertion, or breathing patterns. This study aimed to investigate the influence of these factors on running performance during hypoxic and normoxic shuttle-run sprinting. Eight male amateur soccer players performed shuttle-run sprints in hypoxia (FiO2 ∼14.8%) and normoxia (random order). Each session comprized 3 sets of 5 × 10 seconds back and forth sprints (4.5 m), with recovery times between repetitions and sets of 20 seconds and 5 minutes, respectively. Sprinting distance, acceleration patterns, heart rate (HR) and breathing frequency were measured during each session (Zephyr-PSM Training System). Redox state and lactate concentration ([La]) were determined before and after each session, whereas rating of perceived exertion (RPE) was assessed after the sprint sessions. Overall distance covered was similar during hypoxia and normoxia sprinting (Δ −8.3 ± 14.3 m, 95% CI −20.2 to 3.6, p > 0.05). During the third set, distance tended to be reduced in hypoxia compared with normoxia (169 ± 6 m, 95% CI 164–174 vs. 175 ± 4 m, 95% CI 171–178, p = 0.070). Differences in breathing frequency during sprinting in hypoxia and normoxia were associated with individual reductions in sprinting distance (r = −0.792, p = 0.019). Despite a somewhat lower running distance during the third set and similar [La], RPE, HR, and redox responses, the preserved overall running distance indicates that the training stimulus might be enhanced in hypoxia compared with normoxia. Alteration of the respiratory patterns during repeated sprinting in hypoxia might be one factor, besides others, responsible for a potential performance loss. It could be hypothesized that respiratory pattern adaptations are involved in potential performance improvements after hypoxia repeated sprint training.
Axonal Degeneration in Retinal Ganglion Cells Is Associated with a Membrane Polarity-Sensitive Redox Process
Authors: Almasieh Mohammadali , Catrinescu Maria-Magdalena , Binan Loïc , Costantino Santiago , Levin Leonard A. 
Published: March 2017

Axonal degeneration is a pathophysiological mechanism common to several neurodegenerative diseases. The slow Wallerian degeneration (WldS) mutation, which results in reduced axonal degeneration in the central and peripheral nervous systems, has provided insight into a redox-dependent mechanism by which axons undergo self-destruction. We studied early molecular events in axonal degeneration with single-axon laser axotomy and time-lapse imaging, monitoring the initial changes in transected axons of purified retinal ganglion cells (RGCs) from wild-type and WldSrat retinas using a polarity-sensitive annexin-based biosensor (annexin B12-Cys101,Cys260-N,N′-dimethyl-N-(iodoacetyl)-N′-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) ethylenediamine). Transected axons demonstrated a rapid and progressive change in membrane phospholipid polarity, manifested as phosphatidylserine externalization, which was significantly delayed and propagated more slowly in axotomized WldSRGCs compared with wild-type axons. Delivery of bis(3-propionic acid methyl ester)phenylphosphine borane complex, a cell-permeable intracellular disulfide-reducing drug, slowed the onset and velocity of phosphatidylserine externalization in wild-type axons significantly, replicating the WldSphenotype, whereas extracellular redox modulation reversed the WldSphenotype. These findings are consistent with an intra-axonal redox mechanism for axonal degeneration associated with the initiation and propagation of phosphatidylserine externalization after axotomy.SIGNIFICANCE STATEMENTAxonal degeneration is a neuronal process independent of somal apoptosis, the propagation of which is unclear. We combined single-cell laser axotomy with time-lapse imaging to study the dynamics of phosphatidylserine externalization immediately after axonal injury in purified retinal ganglion cells. The extension of phosphatidylserine externalization was slowed and delayed in Wallerian degeneration slow (WldS) axons and this phenotype could be reproduced by intra-axonal disulfide reduction in wild-type axons and reversed by extra-axonal reduction in WldSaxons. These results are consistent with a redox mechanism for propagation of membrane polarity asymmetry in axonal degeneration.
Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4
Authors: Pfeiffer Annika , Luijsterburg Martijn S , Acs Klara , Wiegant Wouter W , Helfricht Angela , Herzog Laura K , Minoia Melania , Böttcher Claudia , Salomons Florian A , van Attikum Haico , Dantuma Nico P 
Published: March 2017

AbstractThe SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response. We find that ataxin‐3 negatively regulates ubiquitylation of the checkpoint mediator MDC1, a known RNF4 substrate. Loss of ataxin‐3 markedly decreases the chromatin dwell time of MDC1 at DSBs, which can be fully reversed by co‐depletion of RNF4. Ataxin‐3 is recruited to DSBs in a SUMOylation‐dependent fashion, and in vitro it directly interacts with and is stimulated by recombinant SUMO, defining a SUMO‐dependent mechanism for DUB activity toward MDC1. Loss of ataxin‐3 results in reduced DNA damage‐induced ubiquitylation due to impaired MDC1‐dependent recruitment of the ubiquitin ligases RNF8 and RNF168, and reduced recruitment of 53BP1 and BRCA1. Finally, ataxin‐3 is required for efficient MDC1‐dependent DSB repair by non‐homologous end‐joining and homologous recombination. Consequently, loss of ataxin‐3 sensitizes cells to ionizing radiation and poly(ADP‐ribose) polymerase inhibitor. We propose that the opposing activities of RNF4 and ataxin‐3 consolidate robust MDC1‐dependent signaling and repair of DSBs.