bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of implementing a patient-ventilator asynchrony (PVA) management protocol on clinical outcomes in ICU patients
Authors: Ahvazy Maryam Roze , Adineh Mohammad , Savaie Mohsen , ghanbari Saeed 
Published: October 2024

Abstract

Background
Mechanical ventilation is a critical life support for ICU patients. However, this intervention can be associated with complications such as patient-ventilator asynchrony (PVA) and subsequent adverse events. This study aimed to investigate the impact of implementing a PVA management protocol on clinical outcomes in ICU patients.
Methods
In this randomized controlled trial conducted in 2023, 66 mechanically ventilated patients admitted to the ICU of a hospital affiliated with Ahvaz Jundishapur University of Medical Sciences, Ahvaz, were randomly assigned to either an intervention or control group. For the intervention group, PVA was assessed twice daily during the morning and evening shifts, and interventions were performed according to the protocol if necessary. The control group did not receive any specific protocol for PVA management. Data were collected using a checklist and analyzed using SPSS version 22.
Results
There was a significant difference between the intervention and control groups in terms of duration of mechanical ventilation (p < 0.001), length of ICU stay (p < 0.001), and successful weaning from the ventilator (p = 0.026). In all three dimensions, the intervention group showed better outcomes. However, there was no significant difference between the two groups in terms of ICU mortality (p = 0.138) or self-extubation (p = 0.85).
Conclusion
The use of a PVA management protocol can lead to positive outcomes such as reduced duration of mechanical ventilation, shorter ICU stay, and increased successful weaning from the ventilator for ICU patients. Given the promising results of this study, it is recommended that this easy-to-implement and cost-effective PVA management protocol be widely adopted in ICU settings. Further research is needed to solidify these findings and explore potential variations in implementation.
Septate Gallbladder In Adult:Case Report
Authors: Wani Imtiaz 
Published: October 2024

Abstract

Introduction
Septate gallbladder is rare in surgery. This may be an incidental finding during laparoscopic cholecystectomy.
Case History
A 42 year old female had laparoscopic cholecystectomy for symptomatic cholelithiasis. She had diagnosis of longitudinal septum during decompression of of gallbladder through port for retrieval of gallstones.
Conclusion
Septum of gallbladder is rare and may be diagnosed intraoperatively during laparoscopic cholecystectomy. This septate gallbladder has usually multiple calculi inside lumen.
Association of the beta-2-adrenergic receptor (ADRB2) rs1042714 variant with retinopathy of prematurity: case-control and functional pathways analysis
Authors: Chmielarz-Czarnocińska Anna , Durska Anna , Skulimowski Bartosz , Sobaniec Alicja , Gotz-Więckowska Anna , Strauss Ewa 
Published: October 2024

Abstract

Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness globally. The clinical progression of ROP exhibits notable similarities to infantile hemangioma (IH), suggesting shared risk factors and underlying mechanisms. This study aimed to investigate the influence of variants in genes postulated for IH—specifically, anthrax toxin receptor 1 (ANTXR1), beta-2-adrenergic receptor (ADRB2), Fms-related tyrosine kinase 4 receptor (FLT4), kinase insert domain receptor (KDR), and insulin-like growth factor 1 receptor (IGF1R)—on the development and severity of ROP. In our analysis of 210 infants born at a gestational age of less than 33 weeks, we identified the ADRB2 rs1042714G variant allele as a significant risk factor for ROP, particularly its proliferative form. This risk was exacerbated by interactions with factors associated with neonatal respiratory failure, such as surfactant therapy, postnatal resuscitation, and mechanical ventilation, as well as the angiotensin II type 1 receptor variant (AGTR1 rs5186A > C), previously linked to ROP risk in meta-analyses. Moreover, STRING protein-protein interaction analysis revealed that the ADRB2 protein interacts directly with a component of the vascular endothelial growth factor signaling pathway. These findings highlight potential pharmacological targets for ROP interventions, emphasizing the importance of understanding genetic contributions to this complex condition.
NIR Spectroscopy Application for Quality Control of Wheat Grain Produced in Albania
Authors: Mato Lorena , Osmanaj Arben , Topi Ardiana , Topi Dritan , Bajraktari Naser 
Published: October 2024

Abstract

Wheat and its processed flour-based items have been one of the main staple foods of Europeans, including Albanians. Its nutritional importance is attributed to its role as a crucial source of microelements and its versatility for conversion into many processed products, including bread, pasta, and pastries. Global marketplaces are concentrating on their quality indicators about safety and security. The study utilized near-infrared spectroscopy to assess the quality of domestically grown wheat by analyzing physicochemical characteristics, including protein, gluten, starch, moisture, and sedimentation index. This study included the application of NIRS in tandem with machine learning as a sustainable processing and quality assessment tool in cereals. Seventy-five samples were gathered from various areas throughout the 2022 harvesting season, either straight from the field or from silos. The protein content varied from 9.6–15.0%, with a mean of 12.7%. The gluten concentration varied between 19.4% and 37.5%, with a mean of 27.5%. The starch content ranged from 66.3–71.5%, with a mean value of 68.9%. The sedimentation index was measured between 21.1 and 57.8 cm3, with an average of 37.6 cm3. The moisture level varied between 9.8% and 12.5%, indicating that all wheat samples remained within the maximum limit of 14.5% stipulated by national and European Union food regulations. The crop quality indicators generated in Albania met the quality criteria established by EU and state food legislation.
Effects of nalbuphine and sufentanil on stress response and immune response in patients undergoing thoracoscopic unilateral lobectomy : A randomized controlled trial
Authors: Du Chengxu , Cheng Qianyi , Chen Pan , Xin Wenqi 
Published: October 2024

Abstract

Background:
According to the statistics of the American Cancer Society in 2024, the incidence of lung cancer ranks second, but its mortality rate ranks first. Thoracoscopy is one of the commonly used surgical methods in recent years. This study was to investigate the effects of nalbuphine on stress response, immune function and analgesic effect in patients after thoracoscopic surgery.
Methods
This study was a prospective trial of patients after thoracoscopic lung cancer resection. The cohort was randomly divided into two groups : nalbuphine group ( RN group ) and sufentanil group ( RS group ). Thoracic paravertebral nerve block was performed before surgery in both groups. RN group : 0.75% ropivacaine ( 10ml ) + nalbuphine ( 0.2mg / kg ) + normal saline = 20ml. RS group : 0.75% ropivacaine ( 10ml ) + sufentanil ( 0.2µg / kg ) = 20ml. After surgery, all patients were rescued with PCIA. RN group : nalbuphine 2 mg / kg + normal saline = 150 ml, RS group : sufentanil (2 µg / kg ) + normal saline = 150 ml.
Results:
Compared with RS group, ( 1 ) CD3 in T2 and T3 RN group was higher ( P < 0.05 ). ( 2) ACTH in RN group was lower at T3 ( P < 0.05 ). ( 3 ) IL-6 in RN group was lower at T3 ( p < 0.05 ) ; ( 4 ) compared with RS group, the VAS scores of patients in RN group were significantly lower within 2 hours and 24 hours after operation ( P < 0.05 ).
Conclusion :
In patients undergoing thoracoscopic lobectomy, nalbuphine can reduce stress response and immunosuppression, reduce postoperative inflammatory response, relieve postoperative rest pain, and facilitate postoperative rehabilitation.
Groundwater Quality of Bogoberi in Calabar Municipality in Cross River State, Southeastern Nigeria.
Authors: Chukwura-Osoagba Uche Ogugua , Igwilo Paul Chinedu , Opara Clinton Chijioke , Akam Allen Dibang 
Published: October 2024

Abstract

Groundwater quality investigation was carried out in Bogoberi community in Calabar Municipality Local Government Area in Cross River State, Nigeria. The study was conducted to determine the quality of groundwater for drinking and other domestic purposes. Borehole water samples were collected and subjected to standard field and laboratory techniques, and analyzed for the physicochemical parameters. The groundwater samples were slightly acidic and soft when compared with the WHO standards and Nigerian Standards for Drinking water Quality. The electrical conductivity ranged from 97.2 to 254 µS/cm. The alkalinity ranged from 15 to 25 mg/L. The dissolved oxygen and biochemical oxygen demand ranged from 2.5 to 5.2 and 0 to 0.06 mg/L, respectively. The total dissolved solids ranged from 65.12 to 170.18 mg/L. The nitrate and sulphate ranged from 0.15 to 0.48 and 0 to 10.03 mg/L, respectively. The study area is dominated by the Calabar Flank unit. It is underlained by Teritary and Quarternary to Recent sediments known as the Benin Formation (Coastal Plain sands). The Benin Formation consists of alternating sequences of gravel and sand of various grain size, silt, clay and alluvium. In the area, the alternating sediments built up a multi-aquifer system. The Cretaceous sediments include mostly conglomerate, limestone, sandstone, mudstone, shale and marl of Calabar Flank. Statistical analysis gave significant correlation (at 0.05) between electrical conductivity, total dissolved solids, total hardness, alkalinity, and many other elements. The study aids in the understanding of chemistry of groundwater and setting background for related detailed study for long-term monitoring and management.
Factor structure and psychometric properties of the German version of the Reward-based Eating Drive scale
Authors: Herhaus Benedict , Barlang Marlene , Berth Hendrik , Vainik Uku , Epel Elissa S. , Tomiyama A. Janet , Mason Ashley E. , Petrowski Katja 
Published: October 2024

Abstract

Objective: The reward-based eating drive (RED) scales are well-established self-report scales that measure reward-related eating behavior. However, German versions of the RED has not yet been created and validated. Therefore, the aim of the present study was to develop and psychometrically evaluate a German version of the RED.
Method: A German university sample (N=311 medical undergraduates) completed a survey including the RED-9 and the RED-13, as well as several related measures, to test the established factor structure using a confirmatory factor analysis. Construct validity was assessed by correlation analysis with standardized and internationally established questionnaires measuring reward-related eating.
Results: The German 9-item RED (RED-9) with the 3-factor model showed the best psychometric properties in terms of fit indices with acceptable internal consistency, good item rest correlation, and good construct validity with other reward eating scales. There was also a positive association between the German RED-9 total score and BMI.
Conclusions: In conclusion, the German RED-9 is a valid and reliable instrument for the assessment of reward-related eating behavior in non-pathological populations. Further research is needed to better understand associations among reward-related eating, obesity, and diabetes in the German population.
The effect of combined treatment with cold atmospheric plasma and doxorubicin on melanoma: a critical umbrella systematic review and meta-analysis of experimental studies
Authors: Rostami Zeinab , Alizadeh-Navaei Reza , Golpoor Monireh , Yazdani Zahra , Rafiei Alireza 
Published: October 2024

Abstract

Objective: Melanoma is responsible for the majority of skin cancer deaths, but there are several ways to combat this deadly disease. One method involves the use of anti-neoplastic agents, such as doxorubicin (DOX). Unfortunately, DOX can be toxic and may lead to drug resistance. However, researchers are excited about the potential of cold atmospheric plasma (CAP) to selectively target cancer cells and overcome drug resistance. To gain a better understanding of the effectiveness of the combination of CAP and DOX on melanoma cell viability, cytotoxicity, and cell death, we conducted a comprehensive evaluation and meta-analysis in this study.
Results: A total of 41 studies out of 121 met our inclusion criteria. Pooled analysis revealed that the CAP and DOX combination had a significant effect on cell viability (ES =6.75, 95% CI: 1.65--11.85, and I2 = 71%) and cytotoxicity (ES =11.71, 95% CI: 3.69--19.73, and I2 = 56%). However, no statistically significant association was found between cell death and thecombination treatment.
Conclusions: Our studies confirmed that combined treatment with CAP and DOX has a synergistic effect on reducing cell viability and increasing cytotoxicity in melanoma cells. These results can assist researchers in selecting more effective treatment methods to address melanoma.
Application and nursing cooperation of immediate implant placement supported by dynamic navigation: a retrospective study
Authors: Deng Hua , Geng Ningbo , Dou Xiaolan , Yang Shuling , Wang Haishang , Huang Liufang 
Published: October 2024

Abstract

Background
The dynamic navigation technique is used in implant surgery, and there are many instruments and complex procedures during the operation. Therefore, standardized and smooth doctor-nurse cooperation is particularly important. The purpose of this study is to summarize the practical application of dynamic navigation system in immediate implant placement (IIP), and to preliminarily discuss the perioperative nursing cooperation.
Methods
In this study, 40 patients who underwent IIP using a dynamic navigation system in the Department of dentistry of our hospital from 1 January 2021 to 31 March 2024 were collected and the postoperative implantation accuracy was measured, including cervical deviation, apical deviation, depth deviation and angular deviation, and the key points of nursing cooperation were summarised.
Results
62 implants were successfully placed in 40 patients, and all implants had good initial stability. The deviations of the neck and root under navigation guidance were (1.36 ± 0.65) mm and (1.48 ± 0.65) mm, respectively, and the angular deviation was (3.71 ± 1.32) °. Patients were generally satisfied with the results of the implantation and no serious complications occurred.
Conclusion
The dynamic navigation system can improve the precision and success rate of IIP. The preoperative quality nursing care, the full preparation of instruments and items, and the skilled operative nursing coordination can improve the surgical efficiency and reduce complications.
Clinical trial number: not applicable
Association of Frailty and Quality of Life in Elderly Patients with Permanent Pacemaker
Authors: Gunawan Hendra , Salim Simon , Alwi Idrus , Setiati Siti 
Published: October 2024

Abstract

Background: Understanding quality of life status (QoL) is essential to know patient’s well being after pacemaker implantation. Most of the pacemaker’s recipients are elderly. Elderly patients have been associated with multiple comorbities that may interact one another with frailty is the major comorbid in elderly patients. However, there is not much known about the relationships of frailty and its associate factors towards patient’s quality of life status in pacemaker population. Aim: To analyze the association of frailty status and other factors such as age, gender, BMI, hypertension, diabetes, LVEF to QoL in bradyarrhythmic patients post permanent pacemaker implantation.
Methods: This is a cross-sectional study in cardiovascular outpatient department at Cardiocerebrovascular Integrated Unit in Cipto Mangunkusumo Hospital, Jakarta. Frailty status was assessed with FI-40 score and quality of life was assessed with AQUAREL questionnaire. Data analysis was conducted with bivariate analysis and logistic regression to assess the interaction of risk factors to the quality of life.
Results: There were 135 subjects, 68 (50.4%) people were men, aged 69 (64-78) years old, 64 (47.4%) people was a retiree, with 55 (40.9%) people had high school as education background. There were 101 (74.8%) people with a history of dual chamber permanent pacemaker implantation, with TAVB (40.7%) and SND (30.4%) as the most common etiology. The median duration of permanent pacemaker implantation was 4 (2-5.5) years. After adjusting for confounding factors such as age, sex, LVEF, BMI, frailty status was associated with all domain in AQUAREL questionnaire [8.934 (95%CI: 2.66-30.02) for dyspnea domain, 21.56 (95%CI: 5.09-91.33) for chest dyscomfort domain, and 19.78 (95%CI: 4.93-79.43) for arryhthmia domain].
Conclusion: Frailty status was associated with quality of life in elderly bradyarrhythmic patients post permanent pacemaker implantation in Cipto Mangunkusumo hospital.
Elucidating the Functions of fabF1 and fabF2 in Pseudomonas aeruginosa: Implications for Fatty Acid Metabolism and Pathogenicity
Authors: Hu Zhe , Yu Junfei , Li Mengchen , Liu Xiangru , Zhu Lei 
Published: October 2024

Abstract

Background
Pseudomonas aeruginosa is an opportunistic pathogen associated with severe infections in immunocompromised individuals, including burn patients and those with cystic fibrosis. β-ketoacyl-ACP synthases are a class of key enzymes in bacterial fatty acid metabolism, with functions that directly impact basic cellular metabolism and pathogenicity. Two types of long-chain β-ketoacyl-ACP synthases have been identified: FabB and FabF. This study investigates the roles of fabF1 and fabF2 genes in the fatty acid biosynthesis and virulence of P. aeruginosa PAO1.
Results
Complementation assays in Escherichia coli demonstrated that fabF2can substitute for the E. coli FabB enzyme, while FabF1 exhibits FabF-like activity. In P. aeruginosa PAO1, deletion of fabF1significantly decreased cis-vaccenic acid levels and increased palmitoleic acid, whereas deletion of fabF2 had no effect. The double mutant showed a marked reduction in cis-vaccenic acid. Virulence assays revealed that the ΔfabF1strain exhibited a 63% reduction in rhamnolipid production, while the ΔfabF2strain showed a 45% reduction. The double mutant retained only 28% of wild-type rhamnolipid levels. Additionally, pyoverdine secretion was substantially reduced in the double mutant, and both LasA protease activity and pyocyanin production were compromised. Motility assays indicated reduced swimming, twitching, and swarming abilities in the mutants.
Conclusions
These findings underscore the crucial roles of fabF1 and fabF2 in the fatty acid biosynthesis, virulence factor production, and motility of P. aeruginosa, providing insights into potential targets for antimicrobial development.
Impact of pharmacy clinical service redesign on quantity and quality of pharmacy interventions in a tertiary teaching hospital: a Pre-Post Cohort Study
Authors: Chubaty Adriana J , Wills Carly , Saran Harsheen K , Bordia Aagam S , Yeung Kingston , Widjaja Gabrielle , Penm Jonathan 
Published: October 2024

Abstract

Background
Pharmacists are integral to the multidisciplinary team; however, staffing and resource challenges limit pharmacists' impact. Aligning pharmacists by specialty, rather than traditional ward-based models, may address these challenges.
Aim
This study aims to evaluate the impact of a clinical pharmacy redesign on medication reviews.
Method
The pre-post observational cohort study was conducted at a 550-bed tertiary teaching hospital. The redesign of the clinical pharmacy service was conceived and implemented using redesign methodology. Implemented solutions involved alignment of pharmacists to specialty teams, multidisciplinary teamwork, pharmacist clinical specialisation, an emphasis on clinical documentation, and prioritisation of patients requiring medication review. Pharmacist interventions documented pre- and post-clinical redesign were compared. Two independent reviewers reviewed interventions to classify the type of intervention and determine the impact and significance.
Results
In total, 226 patients were included in the pre-cohort and 468 post. Age (mean 70 vs 69, p-value = 0.404) and other demographics were similar between the cohorts. Pharmacist interventions increased after the clinical pharmacy redesign (n = 310 vs n = 1,106). After the implementation of the clinical pharmacy redesign, there was a significant increase in the median number of clinical interventions per Full-time Equivalent pharmacist (13.5 [0–64] vs 81.5 [3-166], p = 0.004) despite no change in staffing. The redesign showed a positive impact and increase in all interventions, including Process of care interventions (45.2% vs 57.4%, p-value < 0.001).
Conclusion
The redesign of pharmacy services increased pharmacist impact without increasing resource requirements or using screening tools, resulting in improved prioritisation of patients, identifying DRPs and increased interventions.
The lateral acromial angle in patients with rotator cuff tears: MRI vs radiographic measurements
Authors: Nachawati Sofian , Nedelea Georgiana Dana , Dragosloveanu Serban , Capitanu Bogdan Sorin , Gheorghievici Gavril , Haritinian Emil-George 
Published: October 2024

Abstract

Background: The lateral acromial angle (LAA) was first described in 1995 by Banas. The angle is measured using two lines, one is drawn just inferior to the sclerotic line of the acromion undersurface and a second line connects the superior and inferior border of the glenoid fossa. Values of the LAA lower than 78 degrees are associated with a higher prevalence of rotator cuff disease. Originally described on magnetic resonance imaging (MRI), this measurement has since been utilized by other authors on true antero-posterior (AP) radiographs. However, no study has yet described a difference between measuring the LAA on MRI or true AP radiographs, nor has evaluated the importance of scapular kinematics in influencing the value of this angle.
Methods: The clinical data of 610 patients with shoulder pain that came to our clinic from January 2018 and March 2023 were retrospectively analyzed. After applying the inclusion and exclusion criteria, 50 patients were included in the final study population. Patients included were those with a full-thickness rotator cuff tear (n=23, 64%) and partial rotator cuff tears (n=17, 34%) diagnosed on an MRI of the shoulder. All the patients had a true AP radiograph of the shoulder taken in our institution. We measured the lateral acromial angle of all 50 patients on MRI and true AP radiograph.
Results: The Wilcoxon signed-rank test showed a significant difference in LAA measurements between MRI and true AP radiographs, with MRI granting higher values (median 77.57°) compared to radiographs (median 73.05°), and a median difference of 4.84°. The mean age was 54.5 ± 9.8 years (range, 29-74 years), 54% of them were female. Pearson correlation indicated a moderate correlation between the two methods. The Intraclass Correlation Coefficient (ICC) suggested moderate to good agreement, but with notable variability. A Bland-Altman Plot was used to assess the agreement between the two measurement techniques.
Conclusion: MRI provides significantly higher LAA measurements compared to true AP radiographs. Scapular kinematics likely influences these differences, making measurements from MRI and radiographs not perfectly interchangeable with a potential impact on clinical decision making.