bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vulvar Concerns in Women With a History of Abdominoplasty: A Case Series
Authors: Whitis Avery , Elas Diane E. , O'Shea Andrea , Stockdale Colleen K. 
Published: August 2016

Objectives
The aim of the study was to present a series of women with a history of traditional abdominoplasty or circumferential abdominoplasty (belt lipectomy) with vulvar concerns and anatomic changes.

Methods
We describe 5 women with a history of abdominoplasty who were referred with symptoms of vulvar pain, dyspareunia, lower urinary tract symptoms, and/or lesion/mass. Physical examination revealed elevation of the clitoris on the pubic symphysis with or without retraction of the clitoral hood in each.

Results
Abdominoplasty can result in anatomic changes to the female pubic region after elevation of the mons pubis and consequent elevation of the clitoris with or without retraction of the clitoral hood. Although causation cannot be confirmed from this series, a temporal association of vulvar/clitoral pain, pelvic floor dysfunction, and anatomic alterations with or without lesions after abdominoplasty was present in each case.

Conclusions
Awareness regarding potential sequelae from anatomic alteration may lead to improved patient counseling and modified surgical techniques to avoid significant elevation of the mons pubis and vulvar commissure.
The Intragastric Pressure Measurement
Authors: Carbone Florencia , Tack Jan , Hoffman Ilse 
Published: August 2016

ABSTRACTBackground:Impaired gastric accommodation (GA) is proposed as a main pathophysiological mechanism for functional dyspepsia (FD). At present, the gastric barostat is the criterion standard to measure GA. Hence, this procedure is invasive and it may alter gastric physiology. Recently, we proposed the measurement of intragastric pressure (IGP) by means of high‐resolution manometry during nutrient intake as a potential alternative for assessing GA in adults.Objectives:Our aim was first to study the feasibility of the IGP measurement with nutrient tolerance in children with FD and second to compare these results with young healthy adults.Methods:A high‐resolution manometry probe and a feeding tube were positioned in the proximal stomach. The IGP was measured before and during intragastric infusion of a nutrient drink (ND, 300 kcal, 60 mL/min). Subjects were asked to score their satiation and epigastric symptoms. The test ended when the subjects scored maximal satiation.Results:A total of 15 healthy volunteers (HVs, 21.7 ± 4.7 years, 21.1 ± 0.3 kg/m2) and 17 patients with FD (14.4 ± 0.7 years, 19.6 ± 0.7 kg/m2) participated. Patients with FD experienced mainly from postprandial fullness (86%), epigastric pain (71%), and bloating (62%). In both groups, intragastric infusion of ND induced a drop in IGP (area above the IGP curve FD: −15.5 ± 3.5 mmHg vs HVs: −18.0 ± 8.7 mmHg; P = 0.57). Patients showed impaired nutrient tolerance compared with HVs (587.6 ± 80.2 vs 936 ± 66.2 kcal; P = 0.003). All patients and HVs tolerated the catheters and could finalize the study.Conclusions:The measurement of IGP during intragastric ND infusion was well tolerated in children. Nutrient tolerance was reduced in children with FD compared with HVs. In the future, this may be a useful tool to assess GA accommodation and nutrient tolerance in children.
Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Results of a Prospective Trial
Authors: Dinkin Marc J. , Patsalides Athos 
Published: August 2016

Background:
Our goal was to evaluate the safety and efficacy of stenting of venous sinus stenosis (VSS) in patients with medically-refractory, medically-intolerant or fulminant idiopathic intracranial hypertension (IIH) in a prospective, observational study.

Methods:
Thirteen patients with IIH who were refractory or intolerant to medical therapy or who presented with fulminant visual field (VF) loss underwent stenting of VSS at the transverse-sinus sigmoid sinus junction, using a Precise Pro carotid stent system (Cordis). Inclusion criteria included papilledema-related VF loss with mean deviation (MD) worse than or equal to −6.00 dB, elevated opening pressure (OP) on lumbar puncture (LP), VSS (either bilateral or unilateral in a dominant sinus), and an elevated (≥8 mm Hg) trans-stenotic gradient (TSG). The main outcome measures were pre- to post-stent change in symptoms related to intracranial hypertension, MD (in dB) on automated (Humphrey) VFs, grade of papilledema (1–5), retinal nerve fiber layer (RNFL) thickness as measured by spectral domain optical coherence tomography (SD-OCT), TSG (mm Hg), and OP on LP (cm H20).

Results:
Improvement or resolution of headaches occurred in 84.7% of patients, pulse-synchronous tinnitus in 100%, diplopia in 100%, and transient visual obscuration in 100%. Out of 26 eyes, 21 showed an improvement in MD, with an average improvement of +5.40 dB. Of 24 eyes with initial papilledema, 20 showed an improvement in Frisen grade, (mean change in grade of 1.90). Of 23 eyes undergoing SD-OCT, 21 (91.3%) demonstrated a reduction in RNFL thickness, with a poststent mean thickness of 90.48 μm. Mean change in OP was −20 cm H2O (reduction in mean from 42 to 22 cm H20) with all subjects demonstrating a reduction, although a second stenting procedure was necessary in one patient. Complications of the stenting procedure included one small, self-limited retroperitoneal hemorrhage, transient head or pelvic pain, and one allergic reaction to contrast. No serious adverse events occurred.

Conclusions:
Stenting of VSS is safe and results in reduction of intracranial pressure in patients with IIH. This is associated with improvement in papilledema, RNFL thickness, VF parameters, and symptoms associated with intracranial hypertension.
Compound Muscle Action Potential Decrement to Repetitive Nerve Stimulation Between Hirayama Disease and Amyotrophic Lateral Sclerosis
Authors: Zheng Chaojun , Zhu Dongqing , Lu Feizhou , Zhu Yu , Ma Xiaosheng , Xia Xinlei , Weber Robert , Jiang Jianyuan 
Published: August 2016

Purpose:
To compare repetitive nerve stimulation (RNS) between Hirayama disease (HD) and amyotrophic lateral sclerosis (ALS).

Methods:
The 3-Hz RNS test was performed on bilateral abductor pollicis brevis, abductor digiti minimi, middle deltoid, and upper trapezius muscles in 33 HD patients and 37 ALS patients.

Results:
In HD patients, none of tested muscles showed any abnormal decrements (≥10%). Significant decrements were observed in 73% of the ALS patients, and decrements were more frequently observed in proximal muscles (deltoid: 70.3%; trapezius: 48.6%). Illness duration did not correlate with decrement percentage in either patient group, and there was no relationship between decrement incidence and ALS diagnostic category (P > 0.05).

Conclusions:
The significantly different RNS results between ALS and HD patients support the application of RNS, especially performing RNS in proximal muscles, as a supplementary test in distinguishing these two diseases, even in the early stages. These results may also imply a difference in underlying pathophysiology between ALS and HD.
Machine learning as a tool for predicting insincere effort in power grips
Authors: Hahn Peter , Cenik Eren , Prommersberger Karl-Josef , Mühldorfer-Fodor Marion 
Published: August 2016

AbstractBackgroundIt was not possible to detect the common problem of insincere grip effort in grip strength evaluation until now. The usually used JAMAR dynamometer has low sensitivity and specificity in distinguishing between maximal and submaximal effort. The manugraphy system may give additional information to the dynamometer measurements used to assess grip force, as it also measures the load distribution of the hand while it grips a cylinder. Until now, the data of load distribution evaluation were analyzed by comparing discrete variables (e.g., load values of a defined area). From another point of view, the results of manugraphy measurements form a pattern. Analyzing patterns is a typical domain of machine learning.MethodsWe used data from several studies that assessed load distribution with maximal and submaximal effort. They consisted of 2016 total observations, including 324 patterns of submaximal effort. The rest were from grips with maximal effort. After preparation and feature selection, XGBoost machine learning was used for classification of the patterns.FindingsAfter applying machine learning to the given data, we were able to predict submaximal grip effort based on the inherent pattern with a sensitivity of 94% and a specificity of 100%.InterpretationUsing techniques from applied predictive modeling, submaximal effort in grip strength testing could be detected with high accuracy through load distribution analysis. Machine learning is a suitable method for recognizing altered grip patterns.
High-resolution DNA accessibility profiles increase the discovery and interpretability of genetic associations
Authors: Madar Aviv , Chang Diana , Gao Feng , Sams Aaron J. , Waldman Yedael Y. , Cunninghame Graham Deborah S. , Vyse Timothy J. , Clark Andrew G. , Keinan Alon 
Published: August 2016

AbstractGenetic risk for common autoimmune diseases is influenced by hundreds of small effect, mostly non-coding variants, enriched in regulatory regions active in adaptive-immune cell types. DNaseI hypersensitivity sites (DHSs) are a genomic mark for regulatory DNA. Here, we generated a single DHSs annotation from fifteen deeply sequenced DNase-seq experiments in adaptive-immune as well as non-immune cell types. Using this annotation we quantified accessibility across cell types in a matrix format amenable to statistical analysis, deduced the subset of DHSs unique to adaptive-immune cell types, and grouped DHSs by cell-type accessibility profiles. Measuring enrichment with cell-type-specific TF binding sites as well as proximal gene expression and function, we show that accessibility profiles grouped DHSs into coherent regulatory functions. Using the adaptive-immune-specific DHSs as input (0.37% of genome), we associated DHSs to six autoimmune diseases with GWAS data. Associated loci showed higher replication rates when compared to loci identified by GWAS or by considering all DHSs, allowing the additional discovery of 327 loci (FDR<0.005) below typical GWAS significance threshold, 52 of which are novel and replicating discoveries. Finally, we integrated DHS associations from six autoimmune diseases, using a network model (bird’-eye view) and a regulatory Manhattan plot schema (per locus). Taken together, we described and validated a strategy to leverage finely resolved regulatory priors, enhancing the discovery, interpretability, and resolution of genetic associations, and providing actionable insights for follow up work.
ResistoMap — online visualization of human gut microbiota antibiotic resistome
Authors: Yarygin Konstantin , Kovarsky Boris , Bibikova Tatyana , Melnikov Damir , Tyakht Alexander , Alexeev Dmitry 
Published: August 2016

AbstractSummaryWe created ResistoMap — a Web-based interactive visualization of the presence of genetic determinants conferring resistance to antibiotics, biocides and heavy metals in human gut microbiota. ResistoMap displays the data about more than 1600 published gut metagenomes of the world populations including both healthy subjects and patients. Multiparameter display filters allow visual assessment of the associations between the meta-data and proportions of resistome. The geographic map navigation layer allows to state hypotheses regarding the global trends of antibiotic resistance and correlate the gut resistome variations with the national clinical guidelines on antibiotics application.Availability and implementationResistoMap is publicly available athttp://resistomap.datalaboratory.ru
PAPCcouples the Segmentation Clock to somite morphogenesis by regulating N-cadherin dependent adhesion
Authors: Chal Jérome , Guillot Charlène , Pourquié Olivier 
Published: August 2016

SUMMARYVertebrate segmentation is characterized by the periodic formation of epithelial somites from the mesenchymal presomitic mesoderm (PSM). How the rhythmic signaling pulse delivered by the Segmentation Clock is translated into the periodic morphogenesis of somites remains poorly understood. Here, we focused on the role ofParaxial protocadherin(PAPC/Pcdh8) in this process. We show that in chicken and mouse embryos, PAPC expression is tightly regulated by the Clock and Wavefront system in the posterior PSM. We observed that PAPC exhibits a striking complementary pattern to N-Cadherin (CDH2), marking the interface of the future somite boundary in the anterior PSM. Gain and loss of function ofPAPCin chicken embryos disrupt somite segmentation by altering the CDH2-dependent epithelialization of PSM cells. Our data suggest that clathrin-mediated endocytosis is increased in PAPC expressing cells, subsequently affecting CDH2 internalization in the anterior compartment of the future somite. This in turn generates a differential adhesion interface, allowing formation of the acellular fissure that defines the somite boundary. Thus periodic expression of PAPC downstream of the Segmentation Clock triggers rhythmic endocytosis of CDH2, allowing for segmental de-adhesion and individualization of somites.
Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
Authors: Zhang Feiran , Hammack Christy , Ogden Sarah C. , Cheng Yichen , Lee Emily M. , Wen Zhexing , Qian Xuyu , Nguyen Ha Nam , Li Yujing , Yao Bing , Xu Miao , Xu Tianlei , Chen Li , Wang Zhiqin , Feng Hao , Huang Wei-Kai , Yoon Ki-jun , Shan Chao , Huang Luoxiu , Qin Zhaohui , Christian Kimberly M. , Shi Pei-Yong , Xu Mingjiang , Xia Menghang , Zheng Wei , Wu Hao , Song Hongjun , Tang Hengli , Ming Guo-Li , Jin Peng 
Published: August 2016

AbstractZika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed to Asian ZIKVC, African ZIKVM, and dengue virus (DENV). In contrast to the robust global transcriptome changes induced by DENV, ZIKV has a more selective and larger impact on expression of genes involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes and TP53. P53 inhibitors can block the apoptosis induced by both ZIKVCand ZIKVMin hNPCs, with higher potency against ZIKVC-induced apoptosis. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. These datasets will help to investigate ZIKV-host interactions and identify neurovirulence determinants of ZIKV.
Network Identification Methods
Authors: Chang Young Hwan , Clair Tomlin J. ,   ICBP Member
Published: August 2016

AbstractRecently, network inference algorithms have grown tremendously in the field of systems biology because network identification is essential for understanding relationships between regulation mechanisms for genes, elucidating functional mechanisms underlying cellular processes, as well as identifying molecular targets for discoveries in medicines. This article provides a brief overview of different approaches used to identify biological networks and reviews recent advances in network identification.
The evolution of business ethics research in the realm of tourism and hospitality
Authors: Köseoglu Mehmet Ali , Sehitoglu Yasin , Ross Gary , Parnell John A. 
Published: August 2016

Purpose
This paper aims to illustrate how business ethics research is progressing in the tourism and hospitality (T/H) industries and suggest a research agenda.

Design/methodology/approach
This study applies bibliometric analysis to articles related to business ethics topics in the T/H fields published between 1995 and 2014 in six, nine and five leading hospitality-, tourism- and business ethics-oriented journals, respectively.

Findings
This study provides a broad view on business ethics research in the T/H fields based on leading authors, institutions, themes and methods used over the past two decades.

Research limitations/implications
This study assesses the progress of business ethics research in the hospitality and tourism fields. Only articles published in select, prominent Social Sciences Citation Index journals were analyzed.

Practical implications
This analysis focuses on published articles related to business ethics in the T/H fields. As such, it facilitates researchers, academic scholars and professionals in contributing to the field more effectively and advancing scientific progress in the literature. It aids practitioners by evaluating the extent to which scholars have investigated key issues in the field.

Originality/value
This study is the first to utilize bibliometric analysis to assess business ethics research focusing on T/H activities published in leading tourism, hospitality and business ethics journals.
Environmental management strategy and organizational citizenship behaviors in the hotel industry
Authors: Yoon Donghwan , Jang Jichul , Lee JungHoon (Jay) 
Published: August 2016

PurposeRecently, the hotel industry has increased its adoption of environmental management practices. Because the research on hotel environmental management often overlooks organizational factors, this study aims to investigate the effects of an environmental management strategy (EMS) on organizational citizenship behavior and tested the mediating roles of organizational trust and commitment in explaining those effects.Design/methodology/approachAn online survey of US hotel employees yielded 373 complete responses. Data were analyzed with structural equation modeling.FindingsEMS positively affected organizational trust and commitment, which ultimately influenced organizational citizenship behavior. Furthermore, organizational trust and commitment fully mediated the relationship between EMS and organizational citizenship behavior.Practical implicationsThe results establish the foundation for applying EMS in organizational operations. The findings can benefit managers, as they show how hotel firms’ prosocial practices can enhance employees’ positive behaviors.Originality/valueDespite the importance of employee attitudes and behaviors, little is known about the mechanism by which employees perceive the influence of an EMS on organizational citizenship behaviors. Therefore, the study examined organizational trust and commitment as mediators of the relationship between EMS and organizational citizenship behavior.
Factors affecting memorability of service failures: a longitudinal analysis
Authors: Kim Jong-Hyeong , Jang SooCheong (Shawn) 
Published: August 2016

PurposeThis study aims to identify the influences that lead to better memorability of a service by focusing on type of service failure, recovery condition and frequency of occurring.Design/methodology/approachThis study used a quasi-experimental design in which customers answered questions about a restaurant they had recently patronized and then evaluated experimentally generated failure and recovery scenarios. Two follow-up contacts were made (by phone and e-mail) to assess their memory of the imagined service failures stimulated by the scenarios. Participants were asked how clearly and vividly they could recollect the service failure and to indicate their behavioral intentions at the time of recall.FindingsThe type of service failure and the subsequent recovery efforts significantly affect whether negative service experiences are memorable. Specifically, individuals showed a higher likelihood of vividly recalling a core service failure than an interactional one. Moreover, service recoveries were found to be helpful in decreasing the memorability of service failures, and that they were effective in decreasing the resulting negative customer behavioral intentions (i.e. switching behaviors and negative word-of-mouth). However, frequently occurred service failures did not significantly influence the memorability of the failures.Practical implicationsThe current study suggested what characteristics of service failures and situations lead to strong memorability and significantly affect future behavior. Thus, the findings provide important implications for avoiding and handling the failures that trigger strong memorability.Originality/valuePrevious researchers have emphasized on the importance and urgency of preventing critical service failures. However, it is still unclear what type of service failures and/or factors are critical ones. The current study expands the knowledge by incorporating service failures with memory and investigates the characteristics of memorable service failures, which are likely to be remembered more vividly.
Antecedents and outcomes of marketing innovation
Authors: Nieves Julia , Diaz-Meneses Gonzalo 
Published: August 2016

PurposeThe purpose of this paper is to analyze the influence of knowledge resources on marketing innovation and the way learning capability mediates this relationship. In addition, it evaluates the effect of marketing innovation on the financial performance of hotel firms.Design/methodology/approachData from a survey conducted in companies that operate hotel establishments are analyzed using structural equation modelling (SEM). The SEM technique makes it possible to evaluate the multiple and intersected relationships existing among the variables under study.FindingsCollective knowledge has a direct influence on marketing innovation and an indirect effect through the learning capability, but the influence of the knowledge held by individuals on marketing innovation is exercised through the learning capability. In turn, both the learning capability and marketing innovation favor the financial performance of hotel firms.Research limitations/implicationsThe study shows that intangible resources play an important role in achieving marketing innovation and financial performance. Because the hospitality industry is composed of firms with different characteristics, it would be relevant to confirm the model in other hospitality businesses. Future studies could analyze possible links between marketing innovation and other types of performance.Practical implicationsHotel firms can reach higher performance levels if they invest in developing the employees’ knowledge and, fundamentally, in fomenting a higher level of collective knowledge related to the business environment in general. Likewise, the learning capability plays a relevant role in achieving performance in hotels firms.Originality/valueTo date, studies on innovation in the field of hospitality have mainly focused on developing new services, while other types of innovation, such as marketing innovation, have taken a backseat. Likewise, the hospitality literature has paid little attention to knowledge assets. This study deals with both topics, analyzing knowledge resources and the learning capability as possible antecedents of marketing innovation activities. Furthermore, the effect of marketing innovation on the firm’s performance is evaluated.