bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silane modified upconversion nanoparticles with multifunctions: imaging, therapy and hypoxia detection
Authors: Xu Shihan , Zhang Xinran , Xu Hongwei , Dong Biao , Qu Xuesong , Chen Boting , Zhang Shuang , Zhang Tianxiang , Cheng Yu , Xu Sai , Song Hongwei 
Published: February 2016

AbstractHerein, we report a facile route to synthesize silane coated upconversion nanoparticles (UCNPs@silane) with an ultrathin layer (the thickness: 1–2 nm), which not only provides good biocompatibility, but also affords hydrophobic interspace to load organic molecules to realize multifunctions. Besides the function of upconversion imaging of UCNPs, cancer therapy and oxygen level detection can also be realized by the addition of chemotherapy drug, PTX, and oxygen sensitive molecules, Platinum (II) octaethylporphine (PtOEP). In bio-experiments, besides the MTT assays, therapy efficacy of UCNPs@PTX@silane can also be detected with the confocal laser scanning microscopy (CLSM) by staining methods. UCNPs@PtOEP@silane can afford minimally invasive analysis of dissolved oxygen and then respond sensitively to the variance of intracellular oxygen concentration affected by therapeutic UCNPs@PTX@silane.
Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
Authors: Rim Tyler Hyungtaek , Han John Seungsoo , Oh Jaewon , Kim Dong Wook , Kang Seok-Min , Chung Eun Jee 
Published: February 2016

AbstractThe goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. Patients with RVO in 2002 were excluded. The RVO group was composed of patients who received an initial RVO diagnosis between January 2003 and December 2007 (n = 1677). The comparison group was selected (five patients per RVO patient; n = 8367) using propensity score matching according to sociodemographic factors and the year of enrolment. Each patient was tracked until 2013. The Cox proportional hazard regression model was used. AMI developed in 7.6% of the RVO group and 5.3% of the comparison group (p < 0.001) for 7.7 median follow-up periods. RVO increased the risk of AMI development [hazard ratio (HR) = 1.25; 95% Confidence Interval (CI) 1.02 to 1.52]. In the subgroup analysis, RVO patients aged <65 years and the males within this age group had an adjusted HR of 1.47 (95% CI 1.10 to 1.98) and an adjusted HR of 2.00 (95% CI 1.38 to 2.91) for AMI development, respectively. RVO was significantly associated with AMI development.
A novel hepatovirus identified in wild woodchuck Marmota himalayana
Authors: Yu Jie-mei , Li Li-li , Zhang Cui-yuan , Lu Shan , Ao Yuan-yun , Gao Han-chun , Xie Zhi-ping , Xie Guang-cheng , Sun Xiao-man , Pang Li-li , Xu Jian-guo , Lipkin W. Ian , Duan Zhao-Jun 
Published: February 2016

AbstractHepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide. Here, we report on the identification of a novel hepatovirus tentatively named Marmota Himalayana hepatovirus (MHHAV) in wild woodchucks (Marmota Himalayana) in China. The genomic and molecular characterization of MHHAV indicated that it is most closely related genetically to HAV. MHHAV has wide tissue distribution but shows tropism for the liver. The virus is morphologically and structurally similar to HAV. The pattern of its codon usage bias is also consistent with that of HAV. Phylogenetic analysis indicated that MHHAV groups with known HAVs but forms an independent branch and represents a new species in the genus Hepatovirus within the family Picornaviridae. Antigenic site analysis suggested MHHAV has a new antigenic property to other HAVs. Further evolutionary analysis of MHHAV and primate HAVs led to a most recent common ancestor estimate of 1,000 years ago, while the common ancestor of all HAV-related viruses including phopivirus can be traced back to 1800 years ago. The discovery of MHHAV may provide new insights into the origin and evolution of HAV and a model system with which to explore the pathogenesis of HAV infection.
Biological movement and the encoding of its motion and orientation
Authors: Benton Christopher P. , Thirkettle Martin , Scott-Samuel Nicholas E. 
Published: February 2016

AbstractAre you walking at me? Biological movement and the encoding of its motion and orientation. A person’s motion conveys a wealth of information that ranges from the complex, such as intention or emotional state, to the simple, such as direction of locomotion. How we recognise and recover people’s motion is addressed by models of biological motion processing. Single channel models propose that this occurs through the operation of form template neurons which respond to viewpoint dependent snapshots of posture. More controversially, a dual channel approach proposes a second stream containing motion template neurons sensitive to view dependent snapshots of biological movement’s characteristic local velocity field. We used behavioural adaptation to look for the co-encoding of viewpoint and walker motion, a hallmark of motion template analysis. We show that opposite viewpoint aftereffects can simultaneously be induced for forwards and reversed walkers. This demonstrates that distinct populations of neurons encode forwards and reversed walking. To account for such aftereffects, these units must either be able to inhibit viewpoint-encoding neurons, or they must encode viewpoint directly. Whereas current single channel models would need extending to incorporate these characteristics, the idea that walker motion is encoded directly, such that viewpoint and motion are intrinsically interlinked, is a fundamental component of the dual channel model.
Critical phenomenon of the near room temperature skyrmion material FeGe
Authors: Zhang Lei , Han Hui , Ge Min , Du Haifeng , Jin Chiming , Wei Wensen , Fan Jiyu , Zhang Changjin , Pi Li , Zhang Yuheng 
Published: February 2016

AbstractThe cubic B20 compound FeGe, which exhibits a near room temperature skyrmion phase, is of great importance not only for fundamental physics such as nonlinear magnetic ordering and solitons but also for future application of skyrmion states in spintronics. In this work, the critical behavior of the cubic FeGe is investigated by means of bulk dc-magnetization. We obtain the critical exponents (β = 0.336 ± 0.004, γ = 1.352 ± 0.003 and β = 5.276 ± 0.001), where the self-consistency and reliability are verified by the Widom scaling law and scaling equations. The magnetic exchange distance is found to decay as "Equation missing"r−4.9, which is close to the theoretical prediction of 3D-Heisenberg model (r−5). The critical behavior of FeGe indicates a short-range magnetic interaction. Meanwhile, the critical exponents also imply an anisotropic magnetic coupling in this system.
Smart three-dimensional lightweight structure triggered from a thin composite sheet via 3D printing technique
Authors: Zhang Quan , Zhang Kai , Hu Gengkai 
Published: February 2016

AbstractComplex fabrication process and expensive materials have restricted the development of smart three-dimensional (3D) lightweight structures, which are expected to possess self-shaping, self-folding and self-unfolding performances. Here we present a simple approach to fabricate smart lightweight structures by triggering shape transformation from thin printed composite sheets. The release of the internal strain in printed polymer materials enables the printed composite sheet to keep flat under heating and transform into a designed 3D configuration when cooled down to room temperature. The 3D lightweight structure can be switched between flat and 3D configuration under appropriate thermal stimuli. Our work exploits uniform internal strain in printed materials as a controllable tool to fabricate smart 3D lightweight structures, opening an avenue for possible applications in engineering fields.
Na-ion Storage Performances of FeSex and Fe2O3 Hollow Nanoparticles-Decorated Reduced Graphene Oxide Balls prepared by Nanoscale Kirkendall Diffusion Process
Authors: Park Gi Dae , Cho Jung Sang , Lee Jung-Kul , Kang Yun Chan 
Published: February 2016

AbstractUniquely structured FeSex-reduced graphene oxide (rGO) composite powders, in which hollow FeSex nanoparticles are uniformly distributed throughout the rGO matrix, were prepared by spray pyrolysis applying the nanoscale Kirkendall diffusion process. Iron oxide-rGO composite powders were transformed into FeSex-rGO composite powders by a two-step post-treatment process. Metallic Fe nanocrystals formed during the first-step post-treatment process were transformed into hollow FeSex nanoparticles during the selenization process. The FeSex-rGO composite powders had mixed crystal structures of FeSe and FeSe2 phases. A rGO content of 33% was estimated from the TG analysis of the FeSex-rGO composite powders. The FeSex-rGO composite powders had superior sodium-ion storage properties compared to those of the Fe2O3-rGO composite powders with similar morphological characteristics. The discharge capacities of the FeSex- and Fe2O3-rGO composite powders for the 200th cycle at a constant current density of 0.3 A g−1 were 434 and 174 mA h g−1, respectively. The FeSex-rGO composite powders had a high discharge capacity of 311 mA h g−1 for the 1000th cycle at a high current density of 1 A g−1.
Simultaneous quasi-one-dimensional propagation and tuning of upconversion luminescence through waveguide effect
Authors: Gao Dangli , Tian Dongping , Zhang Xiangyu , Gao Wei 
Published: February 2016

AbstractLuminescence-based waveguide is widely investigated as a promising alternative to conquer the difficulties of efficiently coupling light into a waveguide. But applications have been still limited due to employing blue or ultraviolet light as excitation source with the lower penetration depth leading to a weak guided light. Here, we show a quasi-one-dimensional propagation of luminescence and then resulting in a strong luminescence output from the top end of a single NaYF4:Yb3+/Er3+ microtube under near infrared light excitation. The mechanism of upconversion propagation, based on the optical waveguide effect accompanied with energy migration, is proposed. The efficiency of luminescence output is highly dependent on the concentration of dopant ions, excitation power, morphology and crystallinity of tube as an indirect evidence of the existence of the optical actived waveguide effect. These findings provide the possibility for the construction of upconversion fiber laser.
Microwave detection performance of In0.53Ga0.47As/GaAs0.5Sb0.5 quantum‐well tunnel field‐effect transistors
Authors: Li Wenjun , Fay Patrick , Yu Tao , Hoyt Judy 
Published: February 2016

The performance of In0.53Ga0.47As/GaAs0.5Sb0.5 quantum‐well tunnel field‐effect transistors (TFETs) for microwave‐frequency detection is explored experimentally. The strong nonlinearity of the TFET transfer characteristic, which arises from a combination of band‐to‐band tunnelling between source and channel and gate modulation of the tunnel junction, can be utilised for high‐sensitivity microwave detection. Using an analytical model, it is shown that TFET detection current sensitivity is approximately proportional to the second‐order derivative of the transfer current‐voltage characteristic. Though unoptimised, the large‐area TFET detectors evaluated experimentally exhibit an unmatched voltage sensitivity of 112 kV/W, an impedance‐matched noise equivalent power of 7.0 pW/Hz0.5, and a bandwidth of 4 GHz. The microwave detection performance of TFETs can be enhanced by mitigating parasitic effects, improving the semiconductor/oxide interface quality, and scaling the gate area.
Perfusionsanalyse innerhalb von Speicheldrüsentumoren bei der kontrastmittelverstärkten Sonografie
Authors: Küstermeyer J. , Klingelhöfer G. , Welkoborsky H.-J. 
Published: February 2016

Zusammenfassung
Hintergrund: Ergänzend zur konventionellen Sonografie erlaubt die kontrastverstärkte Ultraschalluntersuchung (CEUS) eine genauere Perfusionsanalyse von Speicheldrüsentumoren zur Einschätzung ihrer Dignität. Bisher wurde bei der Anwendung von CEUS noch kein Vergleich der Perfusion in unterschiedlichen regions of interest (ROI) innerhalb von Speicheldrüsentumoren durchgeführt. Diese Arbeit soll die Perfusion verschiedener Areale innerhalb von Speicheldrüsentumoren untersuchen und vergleichen.
Material und Methoden: In dieser Studie wurden 25 Patienten mit Speicheldrüsentumoren mittels B-Mode- Sonografie, Farbdopplersonografie sowie CEUS untersucht. Die Parameter: Durchmesser, Echoverhalten, Abgrenzbarkeit und insbesondere das Perfusionsverhalten wurden bestimmt. Die vorliegende Arbeit beschreibt eine neue Methode zur Perfusionsanalyse in 6 peripheren und 2 zentralen standardisierten ROI, welche in den Tumoren verteilt wurden. Die Perfusion wurde dabei zwischen den Tumordignitäten und vor allem innerhalb der Tumoren in den standardisiert angelegten ROI miteinander verglichen.
Ergebnisse: Es zeigte sich ein auffälliges Areal der Perfusion (sog. „hotspots“) in der Tiefe der Peripherie der Raumforderungen, welches besondere Charakteristika ihrer Perfusion aufwies. Dabei bestanden signifikante Unterschiede zwischen den benignen und malignen Tumoren.
Schlussfolgerungen: Die beschriebene neue Methode der Auswertung scheint daher die Aussagekraft der CEUS im Bezug auf die Dignitätsdiagnose zu verbessern.
Enantioselective GC–MS analysis of volatile components from rosemary (Rosmarinus officinalis L.) essential oils and hydrosols
Authors: Tomi Kenichi , Kitao Makiko , Konishi Norihiro , Murakami Hiroshi , Matsumura Yasuki , Hayashi Takahiro 
Published: February 2016

Abstract
Essential oils and hydrosols were extracted from rosemary harvested in different seasons, and the chemical compositions of volatile components in the two fractions were analyzed by gas chromatography–mass spectrometry (GC–MS). Enantiomers of some volatile components were also analyzed by enantioselective GC–MS. Classification of aroma components based on chemical groups revealed that essential oils contained high levels of monoterpene hydrocarbons but hydrosols did not. Furthermore, the enantiomeric ratios within some volatile components were different from each other; for example, only the (S)-form was observed for limonene and the (R)-form was dominant for verbenone. These indicate the importance of determining the enantiomer composition of volatile components for investigating the physiological and psychological effects on humans. Overall, enantiomeric ratios were determined by volatile components, with no difference between essential oils and hydrosols or between seasons.
Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages
Authors: Higuchi Hiroshi , Shoji Toru , Iijima Shinji , Nishijima Ken-ichi 
Published: February 2016

Abstract
Siglecs recognize the sialic acid moiety and regulate various immune responses. In the present study, we compared the expression levels of Siglecs in human monocytes and macrophages using a quantitative real-time reverse transcription–polymerase chain reaction analysis. The differentiation of monocytes into macrophages by macrophage colony-stimulating factor or granulocyte macrophage colony-stimulating factor enhanced the expression of Siglec-7 and Siglec-9. The differentiated macrophages were stimulated by lipopolysaccharide (LPS) plus interferon (IFN)-γ or interleukin (IL)-4. The expression of Siglec-10 was enhanced by IL-4, whereas that of Siglec-7 was reduced by LPS plus IFN-γ. The expression of Siglec-9 was not affected by these stimuli. The knockdown of Siglec-9 enhanced the expression of CCR7 induced by the LPS or the LPS plus IFN-γ stimulation, and decreased the IL-4-induced expression of CD200R. These results suggest that Siglec-9 is one of the main Siglecs in human blood monocytes/macrophages and modulates innate immunity.
An enantioselective NADP+-dependent alcohol dehydrogenase responsible for cooxidative production of (3S)-5-hydroxy-3-methyl-pentanoic acid
Authors: Takeda Minoru , Matsumura Aline Tiemi , Kurosaki Kaishi , Chhetri Rajan Thapa , Motomatsu Shigekazu , Suzuki Ichiro , Sahabi Danladi Mahuta 
Published: February 2016

Abstract
A soil bacterium, Mycobacterium sp. B-009, is able to grow on racemic 1,2-propanediol (PD). The strain was revealed to oxidize 3-methyl-1,5-pentanediol (MPD) to 5-hydroxy-3-methyl-pentanoic acid (HMPA) during growth on PD. MPD was converted into an almost equimolar amount of the S-form of HMPA (S-HMPA) at 72%ee, suggesting the presence of an enantioselective MPD dehydrogenase (MPD-DH). As expected, an NADP+-dependent alcohol dehydrogenase, which catalyzes the initial step of MPD oxidation, was detected and purified from the cell-free extract. This enzyme was suggested to be a homodimeric medium-chain alcohol dehydrogenase/reductase (MDR). The catalytic and kinetic parameters indicated that MPD is the most suitable substrate for the enzyme. The enzyme was encoded by a 1047-bp gene (mpd1) and several mycobacterial strains were found to have putative MDR genes similar to mpd1. In a phylogenetic tree, MPD-DH formed an independent clade together with the putative MDR of Mycobacterium neoaurum, which produces opportunistic infections.
Tunicamycin-induced inhibition of protein secretion into culture medium of Arabidopsis T87 suspension cells through mRNA degradation on the endoplasmic reticulum
Authors: Iwata Yuji , Hayashi Noriko , Tabara Kazuki , Mishiba Kei-ichiro , Koizumi Nozomu 
Published: February 2016

Abstract
The N-glycosylation inhibitor tunicamycin triggers endoplasmic reticulum stress response and inhibits efficient protein secretion in eukaryotes. Using Arabidopsis suspension cells, we showed that the reduced secretion of mannose-binding lectin 1 (MBL1) protein by tunicamycin is accompanied by a significant decrease in MBL1 mRNA, suggesting that mRNA destabilization is the major cause of the inhibition of protein secretion in plants.
Transcriptomic features associated with energy production in the muscles of Pacific bluefin tuna and Pacific cod
Authors: Shibata Mami , Mekuchi Miyuki , Mori Kazuki , Muta Shigeru , Chowdhury Vishwajit Sur , Nakamura Yoji , Ojima Nobuhiko , Saitoh Kenji , Kobayashi Takanori , Wada Tokio , Inouye Kiyoshi , Kuhara Satoru , Tashiro Kosuke 
Published: February 2016

AbstractBluefin tuna are high-performance swimmers and top predators in the open ocean. Their swimming is grounded by unique features including an exceptional glycolytic potential in white muscle, which is supported by high enzymatic activities. Here we performed high-throughput RNA sequencing (RNA-Seq) in muscles of the Pacific bluefin tuna (Thunnus orientalis) and Pacific cod (Gadus macrocephalus) and conducted a comparative transcriptomic analysis of genes related to energy production. We found that the total expression of glycolytic genes was much higher in the white muscle of tuna than in the other muscles, and that the expression of only six genes for glycolytic enzymes accounted for 83.4% of the total. These expression patterns were in good agreement with the patterns of enzyme activity previously reported. The findings suggest that the mRNA expression of glycolytic genes may contribute directly to the enzymatic activities in the muscles of tuna.
Early signaling events induced by the peptide elicitor PIP-1 necessary for acetosyringone accumulation in tobacco cells
Authors: Kim Yonghyun , Miyashita Masahiro , Miyagawa Hisashi 
Published: February 2016

Abstract
A peptide elicitor PIP-1 induces defense-related secondary metabolites such as phytoalexin capsidiol in tobacco cells. In this study, we identified one of other metabolites induced by PIP-1 as acetosyringone. Unlike capsidiol accumulation that requires long-term stimulation with PIP-1, acetosyringone was induced by short-term stimulation with PIP-1. The importance of NADPH oxidase in the acetosyringone induction was also demonstrated.
A single aldehyde group can serve as a structural element for recognition by transmembrane protein CD36
Authors: Tsuzuki Satoshi , Amitsuka Takahiko , Okahashi Tatsuya , Kozai Yuki , Matsumura Shigenobu , Inoue Kazuo , Fushiki Tohru 
Published: February 2016

Abstract
Transmembrane protein CD36 is considered to bind its distinct ligands such as long-chain fatty acids primarily by recognizing their terminal carboxyl moiety. In this study, we provide evidence that long-chain fatty aldehydes, such as oleic aldehyde, can be recognized by CD36. We suggest that a single aldehyde group may also serve as one of the structural elements recognizable by CD36.
Talent identification and selection in elite youth football: An Australian context
Authors: O'Connor Donna , Larkin Paul , Mark Williams A. 
Published: February 2016

AbstractWe identified the perceptual–cognitive skills and player history variables that differentiate players selected or not selected into an elite youth football (i.e. soccer) programme in Australia. A sample of elite youth male football players (n = 127) completed an adapted participation history questionnaire and video‐based assessments of perceptual–cognitive skills. Following data collection, 22 of these players were offered a full‐time scholarship for enrolment at an elite player residential programme. Participants selected for the scholarship programme recorded superior performance on the combined perceptual–cognitive skills tests compared to the non‐selected group. There were no significant between group differences on the player history variables. Stepwise discriminant function analysis identified four predictor variables that resulted in the best categorization of selected and non‐selected players (i.e. recent match‐play performance, region, number of other sports participated, combined perceptual–cognitive performance). The effectiveness of the discriminant function is reflected by 93.7% of players being correctly classified, with the four variables accounting for 57.6% of the variance. Our discriminating model for selection may provide a greater understanding of the factors that influence elite youth talent selection and identification.
Plasma 12‐ and 15‐Hydroxyeicosanoids are Predictors of Survival in Pulmonary Arterial Hypertension
Authors: Al‐Naamani Nadine , Sagliani Kristen D. , Dolnikowski Gregory G. , Warburton Rod R. , Toksoz Deniz , Kayyali Usamah , Hill Nicholas S. , Fanburg Barry L. , Roberts Kari E. , Preston Ioana R. 
Published: February 2016

This study aimed to characterize alterations in select eicosanoids in experimental and human pulmonary arterial hypertension (PAH) and to assess their potential utility as predictors of outcome. Using liquid chromatography–mass spectrometry, we performed targeted lipidomic analyses of the lungs and right ventricles (RVs) of chronically hypoxic rats and plasma of consecutive PAH patients and healthy controls. In rat lungs, chronic hypoxia was associated with significantly decreased lung prostacyclin (PGI2)/thromboxane B2 (TXB2) ratio and elevated lung 8‐hydroxyeicosanoid (HETE) acid concentrations. RV eicosanoids did not exhibit any changes with chronic hypoxia. PAH treatment–naïve patients had significantly increased plasma concentrations of TXB2 and 5‐, 8‐, 12‐, and 15‐HETE. The PGI2/TXB2 ratio was lower in PAH patients than in controls, especially in the treatmentnaïve cohort (median: 2.1, 0.3, and 1.3 in controls, treatmentnaïve, and treated patients, respectively, P = 0.001). Survival was significantly worse in PAH patients with 12‐HETEhigh (≥57 pg/mL) and 15‐HETEhigh (≥256 pg/mL) in unadjusted and adjusted analyses (hazard ratio [HR]: 2.8 [95% confidence interval (CI): 1.1–7.3], P = 0.04 and HR: 4.3 [95% CI: 1.6–11.8], P = 0.004, respectively; adjustment was performed with the REVEAL [Registry to Evaluate Early and Long‐Term PAH Disease Management] risk score). We demonstrate significant alterations in eicosanoid pathways in experimental and human PAH. We found that 12‐ and 15‐HETE were independent predictors of survival in human PAH, even after adjusting for the REVEAL score, suggesting their potential role as novel biomarkers.