bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Book of Genesis and other allegorical origin stories of games
Authors: Walther Bo Kampmann 
Published: October 2024

AbstractThis essay delves into the complex interplay between the sacred and the ludic, with a particular emphasis on allegorical origin stories from various religious and mythological traditions, highlighting their portrayal of games and the concept of play. The analysis includes the Judaeo‐Christian Book of Genesis and the Babylonian Enuma Elish. In addition, I explore ‘secular’ texts such as Miguel de Cervantes' Don Quixote, Mark Twain's The Diaries of Adam and Eve, and Tom Stoppard's Rosencrantz and Guildenstern Are Dead. These latter works share a common theme: whimsical characters who originate from game rules and persistently seek to comprehend the underlying mechanisms of their existence and the ‘scripted’ actions they are compelled to perform.
Meeting Report From the 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Philadelphia, PA, November 2023
Authors: Seedor Rino S. , Aplin Andrew E. , Bertolotto Corine , Carvajal Richard D. , Deacon Nigel , Doble Katie , Hamid Omid , Haq Rizwan , Kadosh Miriam , Khan Shaheer , Kraska Jacqueline , Lutzky Jose , McKean Meredith , Montazeri Kamaneh , Moser Justin , Onken Michael , Orloff Marlana , Sacco Joseph J. , Smalley Keiran , Selig Sara M. 
Published: October 2024

ABSTRACTThe 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting was held in Philadelphia on November 6, 2023. There is increased awareness and dedicated research in uveal melanoma (UM), but unmet needs remain in the prevention, detection, and treatment of UM. The purpose of this meeting was to provide an international forum for the exchange of research ideas, to allow for discussion of basic science as well as clinical research on UM, and to gather input about advocacy and patient needs.
Perioperative Complications After Pediatric Liver Transplantation—A Retrospective Analysis of 421 Cases
Authors: Weigle Clara A. , Wiemann Bengt A. , Tessmer Philipp , Störzer Simon , Novikova Valeriya , Richter Nicolas , Klempnauer Jürgen , Pfister Eva‐D. , Baumann Ulrich , Leiskau Christoph , Vondran Florian W. R. , Oldhafer Felix , Beetz Oliver 
Published: October 2024

ABSTRACTBackgroundDue to the low incidence of pediatric liver transplantations, short‐ and long‐term data regarding their outcome, details on early postoperative complications and their risk factors are under‐represented in the literature.MethodsWe retrospectively reviewed 1645 LTx performed at Hannover Medical School between January 2005 and December 2021. Of these, 421 transplantations were performed in 405 pediatric recipients. Univariate and multivariate binary logistic regressions were performed to identify independent risk factors for the onset of selected perioperative complications requiring intervention within the first 30 days following transplantation and their influence on graft and patient survival.ResultsPleural effusions represent the most common postoperative complication observed in 49.4% (n = 208) of cases, followed by vascular complications in 22.6% (n = 95) and biliary complications in 20.0% (n = 84) of cases. Donor age (OR: 1.019; p = 0.010) and recipient age between 3 and 12 years (OR: 1.849; p = 0.008) were identified as independent risk factors for the onset of pleural effusions. Retransplantations within the first year after LTx were necessary in 11.4% of all cases (n = 48). Twenty (4.8%) patients died within the first year after LTx.ConclusionPleural effusions requiring postoperative intervention were observed in approximately half of the pediatric recipients. Therefore, the preemptive intraoperative placement of a chest drain under sterile conditions and general anesthesia should be considered. Our data further indicate that a two‐stage procedure for biliary reconstruction may be the preferred procedure in patients at risk of early bile duct complications and retransplantation within the first year.
Using a virtual reality game to train biofeedback‐based regulation under stress conditions
Authors: Daniel‐Watanabe Lucie , Cook Benjamin , Leung Grace , Krstulović Marino , Finnemann Johanna , Woolley Toby , Powell Craig , Fletcher Paul 
Published: October 2024

AbstractPhysiological regulation strategies can be effective in reducing anxiety. However, while these strategies are often learned and practised under low‐stress conditions, they are more likely to be required under conditions of high stress. We created virtual reality (VR) biofeedback games to both teach participants a breathing technique and then practise that technique under stress. We present two studies: the first provides a proof of concept, demonstrating that participants can apply the breathing technique during stress, with a significant lowering of both respiration rate and increase in heart rate variability (HRV) under stress (p < .001). The second study explicitly evaluated the effectiveness of training by comparing trained and untrained groups. Training was associated with a significantly greater HRV (p = .008) under stress. In within‐group comparisons of HRV during stress compared to a baseline stressor presented before training, the trained group showed a significantly greater increase compared to untrained controls (p = .025). Our results show the feasibility and potential effectiveness of VR‐based games for biofeedback training under experimentally applied stress. This may offer the opportunity for clinical techniques to more closely reflect the circumstances under which those techniques will be required.
Influence of Dietary Fatty Acids on Fish Sperm Tolerance to Cryopreservation
Authors: Figueroa Villalobos Elías , Pereira Wellison Amorim , Pérez‐Atehortúa Maritza , Sandoval‐Vargas Leydy , Romero J. , Oliveira Ricardo P. S. , Valdebenito Iván , Villasante Alejandro 
Published: October 2024

ABSTRACTTo meet growing fish demand, aquaculture must develop sustainable, cost‐effective, and high‐performance fish feed formulations for industry advancement. Plant‐based lipids are a viable alternative to forage fish ingredients in finfish diets. However, most plant‐derived lipids lack long‐chain polyunsaturated fatty acids (LC‐PUFA) like EPA and DHA, which are nutritionally essential for fish. This review summarizes recent findings on the nutritional aspects of fish brood stock and sperm quality, emphasizing the effects of fatty acids on reproductive outcomes. Studies indicate that substituting fish oil with plant oils alters the fatty acid profiles in fish tissues and gametes, potentially compromising sperm quality, cryopreservation success, and progeny viability. Sperm membrane lipids, including EPA, DHA, and ARA, are vital for motility and fertilization rates post‐thaw. Additionally, cryopreservation has been linked to molecular and epigenetic alterations in sperm, which may negatively affect offspring quality. The role of mRNA and noncoding RNA in regulating sperm function and embryonic development is well known, and thus any damage to these molecules as a consequence of cryopreservation might induce long‐term effects on offspring. Proteomic analyses reveal that cryopreservation can lead to significant protein loss in sperm, diminishing their functional and fertilization capabilities. Optimizing cryoprotectant protocols and freezing techniques is crucial to reduce damage, while dietary fatty acids play a key role in preserving sperm quality during cryopreservation stress. Further research with omic technologies is crucial to fully understand sperm tolerance to cryopreservation, which will improve reproductive outcomes and enhance sustainability and quality in aquaculture.
Biosafety in Norwegian Aquaculture—Risks and Measures in RAS Facilities and Well‐Boats
Authors: Slette Hans Tobias , Salomonsen Cecilie , Størkersen Kristine , Tveit Guro Møen , Misund Andreas , Lona Eivind 
Published: October 2024

ABSTRACTBiosafety is a central concern in Norwegian salmon farming, as diseases and parasites are common. Continued production depends on preventing and controlling diseases and parasites. A critical part of the farmed salmon's life is during smolt production and the following well‐boat transport out to sea. Biosafety here is thus essential, and there is a need for an overview of risk factors and measures. Biosafety is related to the technical solutions' design, construction, cleaning, and maintenance, that can be studied through field work, interviews, and document analysis. This paper presents results from a study identifying risk factors related to technical solutions in smolt production (with RAS—recirculating aquaculture systems) and well‐boats, and potential measures to reduce risk. Risk factors for RAS facilities are divided into four main groups: Introduction of pathogens to the facility, spread of pathogens inside the facility, growth of pathogens inside the facility, and additional risks. Risk factors for well‐boats are divided into three main groups: Introduction of pathogens through intake water, spread of pathogens between fish groups, and spread of pathogens from well‐boat to the environment. Measures are proposed to mitigate the identified risk factors. The lists are not exhaustive, and risk magnitude is not quantified, so effect of measures is not calculated. Still, the measures' potential for risk reduction and implementation (cost/benefit) are discussed, suggesting measures vital for biosafety in RAS facilities and well‐boats.
Low Testosterone Concentration Improves Colonisation and Viability in the Co‐Cultured Goat Spermatogonial Stem Cell With Sertoli Cells
Authors: Salimi Hossein , Rahimi Feyli Peyman , Yari Kheirollah , Wong Alexei , Moghaddam Ali Asghar 
Published: October 2024

ABSTRACTSpermatogonial stem cells (SSCs) maintain spermatogenesis through self‐renewal and differentiation. The proliferation of SSCs in culture systems can provide a valuable source of germ cells. Several studies have investigated new reproductive technologies, including the production of transgenic animals and recombinant proteins secreted from milk in goats. While studies in other species exist, research on goat SSC culture remains limited. We investigated the impact of different testosterone concentrations on the survival and colonisation of cocultured goat SSCs with Sertoli cells. Cells were isolated from immature goats using two‐step enzymatic digestion and enriched by differential exclusion method. DMEM/F12 culture medium containing 1% antibiotic and 5% FBS, supplemented with GDNF (20 ng/mL), EGF, bFGF and LIF (10 ng/mL), was used with different testosterone concentrations (0, 60, 120 and 240 μg/mL) and cultured for 10 days. SC subpopulations were confirmed using PGP9.5 immunocytochemistry, and the expression of germ cell markers (ID‐4, UCHL‐1, THY‐1, β1‐integrin, BCL6B, VASA, PLZF and OCT‐4) was evaluated through RT‐PCR. Alkaline phosphatase activity provided additional SSC presence. The survival rate of SSCs after isolation and the number and area of colonies on Days 4, 7 and 10 were measured using an inverted microscope. The presence of PGP 9.5 antigens and germ cell markers (ID‐4, UCHL‐1, THY‐1, β1‐integrin, BCL6B, VASA, PLZF and OCT‐4) was confirmed by immunocytochemistry and RT‐PCR, respectively. According to the results, the group with 60 μg/mL testosterone had the highest number and area of colonies. The number of colonies in the 60 μg/mL testosterone group was significantly higher than the control group (p < 0.05), but no significant difference was observed compared to other groups (p ≥ 0.05). This study suggests that a low testosterone concentration (60 μg/mL) is optimal for goat SSC colonisation and viability in coculture with Sertoli cells, potentially leading to advancements in goat reproductive technologies.
Parental time investments and instantaneous well‐being in the United States
Authors: Bosworth Steven J. , Gimenez‐Nadal José Ignacio , Sevilla Almudena 
Published: October 2024

AbstractThis study investigates the relationship between maternal education, child‐care time, and well‐being in the United States, with a particular focus on the role of societal norms. Highly educated mothers spend more time on childcare compared to their less educated counterparts. Drawing on data from the American Time Use Survey's Well‐Being Modules (2012, 2013, 2021), this research provides a comprehensive examination of maternal activities and well‐being. Notably, educated mothers consistently experience reduced instantaneous happiness during childcare, across various caregiving tasks, despite investing greater time in them. To better understand this pattern, we introduce an identity economics model whose predictions are consonant with the empirical findings. Our model illustrates how societal gender roles differentially influence patterns of time allocation by mothers' education and impact their instantaneous and overall well‐being.
Towards a Decolonial and Anti‐Racist Analysis of the Nation‐State and Nationalism
Authors: Dragoș Simina 
Published: October 2024

ABSTRACTThis paper addresses two calls emerging out of Sociological theory—against methodological nationalism and methodological whiteness—in relation to the study of nations, nation‐states and nationalisms. Building on Meghji's synergy of decolonial and race critical theory, I propose a historicized and globalized analysis of nationalisms and the nation‐state which can respond to these calls whilst also being attentive to the nation‐state and nationalism as sites of violence. I insist upon the importance of understanding ‘race’ and coloniality as foundational aspects to the emergence and functioning of nationalisms and nation‐states. I do so based on the empirical case of the nation‐state Romania and Romanian nationalism, what I call a ‘colonial gray zone’. I argue: (1) that modern colonialism and imperialism shaped the emergence of nation‐states and that, as a result, coloniality shapes the functioning of nation‐states and nationalisms; (2) that modern/colonial ‘race’ is central to the emergence and operation of nation‐states and nationalisms. Ultimately, I urge those concerned with the study of nations, nation‐states and nationalisms to shift their analytical tools towards coloniality and racism, and the scholarship and struggles against them.
Metabolomic differences between exanthematous drug eruption and infectious mononucleosis
Authors: Liu Yanqiu , Guan Qizhen , Liu Liyuan , Ma Lina , Duan Xinsuo , Che Jiaozi 
Published: October 2024

AbstractBackgroundExanthematous drug eruption and infectious mononucleosis (IM) are both exanthematous diseases. Current research on exanthematous drug eruption and IM mainly targets identifying these disorders, the resulting differences at the metabolism level have not yet been systematically analyzed.Materials and methodsA total of 30 cases of exanthematous drug eruption and IM, 10 patients without exanthema and 10 healthy volunteers were enrolled, 3 mL of fasting venous blood was collected, the serum metabolite content was detected by gas chromatography‐mass spectrometry metabolomics.ResultsA total of 165 metabolites were identified, exhibiting significant differences in plasma metabolic trends between exanthematous drug eruption and IM, and pinpointed 28 potential biomarkers. Notable changes were seen in the metabolic activities of the pentose phosphate pathway (PPP), tricarboxylic acid cycle (TCA‐cycle), and galactose metabolism, characterized by increased levels of gluconate, gluconolactone, glucose, galactaric acid, and mannose, along with decreased amounts of pyruvic acid, succinic acid, malic acid, and glycerol, indicating an impairment in the exanthematous drug eruption group's capacity to endure oxidative stress and regulate energy metabolism. In contrast to its medication without rash counterpart, the exanthematous drug eruption group's plasma displayed distinct metabolic routes, predominantly in the processing of arginine and proline, along with the TCA. This resulted in a marked reduction in urea levels and a rise in pyruvate, citrate, and ornithine, indicating hypoxic stress as the primary cause of these rashes. In contrast to the healthy control group, the IM group showed 26 potential biomarkers, marked by increased levels of ketoglutaric acid, malic acid, pyruvic acid, and oxoglutaric acid, and reduced amounts of glutamine, galacturonic acid, arachidonic acid, trimethylphosphonic acid ester, gluconolactone, and indole acetic acid. Mainly, the metabolic pathways included the TCA, breaking down alanine, aspartate and glutamate metabolism, and the processing of D‐glutamine and D‐glutamate metabolism, underscoring the body's crucial role in generating energy and inflammatory agents through the citric acid cycle.ConclusionsThe comparison of serum metabolomic features of exanthematous drug eruptions and IM outlines a unique pattern closely related to the differences in the pathogenesis of these two exanthematous diseases.
Functional Properties and Components of Koenigia alpina Extract
Authors: Lee Kwan‐Woo , Mun Su‐Hyun , Kim Yeon‐A , Kim Hyo‐Rim , Jin Qinglong , Lee Min‐Ki , Park Soo Nam 
Published: October 2024

ABSTRACTBackgroundKoenigia alpina (All.) T.M.Schust. & Reveal (alpine knotweed) is a perennial herb belonging to the Polygonaceae family. Several studies have examined Polygonaceae species’ potential applications as cosmeceutical materials; however, the potential of K. alpina as a cosmeceutical has not yet been studied.Materials and MethodsHydrogen peroxide (H2O2) and lipopolysaccharide were used to induce an inflammatory response in RAW 264.7 cells. 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) radicals and H2O2 were used to evaluate the free‐radical scavenging activity of K. alpina extract and its protective effect against reactive oxygen species (ROS)‐induced cell damage. The whitening, antiaging, and cell proliferation/migration effects of the extracts were evaluated via tyrosinase inhibition, collagenase/elastase inhibition, and wound healing assays, respectively. The anti‐inflammatory effect was confirmed by evaluating nitric oxide (NO) production in RAW 264.7 cells. High‐performance liquid chromatography (HPLC), UV, and MS/MS were used to determine the main components of the extract and fractions.ResultsThe ethyl acetate (EA) fraction and its aglycone fraction showed very high free‐radical scavenging activities (47.5 and 47.1 µg/mL, respectively). The extract/fractions also showed significant tyrosinase inhibition (IC50 = 0.38 mg/mL in EA fraction), collagenase inhibition (IC50 = 0.21 mg/mL in EA fraction), and elastase inhibition (IC50 = 0.57 mg/mL in aglycone fraction). NO production in lipopolysaccharide‐induced RAW 264.7 cells was inhibited by the extract/fractions. The extract also promoted the closure of scratch wounds in HaCaT cells. The K. alpina extract/fractions contained cardamonin, quercetin, and quercitrin.ConclusionK. alpina extracts/fractions showed antioxidant, antiaging, whitening, and anti‐inflammatory activities, suggesting they may have potential as antiaging cosmeceuticals.
Synergistic Commutative Algorithm for Securing Vector Spatial Data via GD‐PBIBD Fingerprint Encoding and Data Encryption
Authors: Yan Qingbo , Yan Haowen , Zhang Liming 
Published: October 2024

ABSTRACTAs a fundamental component that supports business connectivity and enables intelligent decision‐making, vector spatial data encounter increasing copyright and security challenges throughout their lifecycle. There is an imminent need for a comprehensive lifecycle protection solution to ensure data security and adherence to copyright laws. This study introduces an integrated protection scheme designed to address copyright and security issues across the entire lifecycle of vector spatial data. First, DNA encryption is applied to the vector spatial data, with the key subsequently encrypted using the RSA public key. Concurrently, GD‐PBIBD fingerprint encoding is used to generate a fingerprint sequence. Thereafter, this sequence is scrambled using logistic mapping, and a quantization mechanism embeds the scrambled fingerprint sequence into the coordinates. Subsequently, the RSA private key is used to decrypt the key and extract the fingerprint information. Finally, logistic mapping is employed to restore the fingerprint sequence, and Hamming distance calculations are used to identify colluding users and trace potential data leaks. Experimental studies indicate that the proposed DNA encryption algorithm is effective for various types of vector spatial data, including point, polyline, and polygon data. It features a large key space and high key sensitivity. Furthermore, the GD‐PBIBD fingerprint encoding is simple to construct, offers excellent imperceptibility, and provides robust resistance to both single‐ and multi‐user attacks. This research addresses the gap in full lifecycle copyright and security protection for vector spatial data and offers a holistic solution for secure data circulation, thereby demonstrating significant practical value.
Computed tomographic features of severe horn infection in a male Scimitar‐horned oryx (Oryx dammah)
Authors: Le Kayla , Riggs Victoria , Yap Seng Wai , Ernestova Martina , Sebastian Kimberley 
Published: October 2024

AbstractA 3‐year‐old male Scimitar‐horned oryx presented for evaluation of an acutely deformed right horn with right head tilt and right facial pain. Computed tomographic evaluation revealed an increased volume of central fluid/soft tissue attenuation with gas‐attenuating foci within the right horn. The right horn was amputated at the right horn base. Imaging and histopathologic features were consistent with emphysematous osteomyelitis. Following treatment, the patient returned to normal behavior. This is the first veterinary report describing the computed tomographic features of a horn infection in a Scimitar‐horned oryx.
Radiographic findings in dogs with 360 degrees gastric dilatation and volvulus
Authors: Mur Pablo Espinosa , Appleby Ryan , Phillips Kathryn L. , Singh Ameet , Monteith Gabrielle , Gilmour Lindsey J. , Keenihan Erin , Daniaux Lise , Linden Alex zur 
Published: October 2024

AbstractGastric dilatation and volvulus (GDV) is a life‐threatening emergency that requires urgent intervention. Radiographic features associated with 360‐GDV in dogs have not been investigated. The aim of this retrospective observational study is to describe radiographic features and clinical variables in dogs affected with 360‐GDV and to report agreement rates between different radiologists. We also report the sensitivity and specificity of radiographs to diagnose 360‐GDV in dogs. Confirmed 360‐GDV cases were retrieved, and the radiographic findings were compared with dogs presenting with gastric dilatation (GD) and 180‐GDV. Images were reviewed and graded by three blinded board‐certified radiologists. A total of 16 dogs with confirmed 360‐GDV were identified. The median age was 10 years old (2–13 years). The sensitivity for detection of 360‐GDV ranged between 43.7% and 50%, and the specificity between 84.6% and 92.1%. Interobserver agreement on final diagnosis was substantial (Kappa = 0.623; 0.487–0.760, 95% CI). The highest agreement rate was in cases of 180‐GDV (87%), followed by the GD cases (72%) and 360‐GDV (46%). Severe esophageal distension and absence of small intestinal dilation were the only radiographic features specifically associated with 360‐GDV. A similar pyloric position was found between GD and 360‐GDV. Additional radiographic variables that could help differentiate GD from 360‐GDV include the degree of gastric distension and the peritoneal serosal contrast. Two cases with 360‐GDV were misdiagnosed by the three radiologists as GD. In conclusion, radiographically, 360‐GDV cases can reassemble GD and vice versa. Radiologists and clinicians should be aware of the low sensitivity of radiographs for the detection of 360‐GDV.
Oriented Birkhoff sections of Anosov flows
Authors: Asaoka Masayuki , Bonatti Christian , Marty Théo 
Published: October 2024

AbstractThis paper gives three different proofs (independently obtained by the three authors) of the following fact: given an Anosov flow on an oriented 3‐manifold, the existence of a positive Birkhoff section is equivalent to the fact that the flow is ‐covered positively twisted.