bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining bidirectional effects between the autism spectrum disorder (ASD) core symptom domains and anxiety in children with ASD
Authors: Duvekot Jorieke , van der Ende Jan , Verhulst Frank C. , Greaves‐Lord Kirstin 
Published: October 2017

BackgroundAlthough a bidirectional relationship between autism spectrum disorder (ASD) and anxiety symptoms is assumed, few studies have investigated this. Moreover, little is known about potential differential relationships of the two core symptom domains of ASD – social communication impairment and restricted, repetitive behavior – with anxiety over time.MethodParticipants were 130 children with an ASD (M age 6.7 years, 81.5% boys) of whom 79 participated in a follow‐up assessment 2 years later. We used cross‐lagged models to test whether social communication impairment and restricted, repetitive behavior at T0 predicted anxiety at T2 and vice versa.ResultsCrossed‐lagged models showed that anxiety symptoms predicted social communication impairment over time (β = .22, p = .008), but not vice versa (β = −.07, p = .49). There were no significant paths from anxiety symptoms to later restricted, repetitive behavior (β = .11, p = .34) or vice versa (β = −.11, p = .27).ConclusionsOur results do not support a bidirectional relationship between the ASD core symptom domains and anxiety, but suggest that higher levels of anxiety symptoms increase the risk of more social communication impairment over time in children with ASD. This underlines the importance of treating anxiety symptoms to improve both social and emotional functioning.
“Un Favorzote”: Gender and Reciprocity in the Andes
Authors: Wilhoit Mary Elena 
Published: October 2017

ResumenEn este estudio analizo trabajos recíprocos de mujeres en una comunidad rural en Ayacucho, Perú. Se ha estudiado prácticas formales de reciprocidad durante muchas décadas en los Andes, como fundamental para formación social allí, pero esa literatura se ha centrado en los arreglos convocados para la construcción y producción agrícola. Como consecuencia, la reciprocidad ha sido analizado como fenómeno masculino. Investigación etnográfica con mujeres demuestra que su ayuda mutua en crianza de hijos y otras tareas les permitía entrar a mercados laborales y aprovecharse de programas estatales que buscaban mejorar sus circunstancias, mientras les proveía entornos de apoyo mutuo que muchas habían carecido en el matrimonio. Comprensión de esta forma de reciprocidad es fundamental en Ayacucho, donde el número de madres solteras ha aumentado desde las décadas de guerra. Este estudio presenta un complemento fundamental para descripciones tradicionales de ayni, analizando practicas de mujeres para prosperar en condiciones difíciles. [Andes, clase, género, labor, Perú]
Revisiting the God/World Difference
Authors: Holmes Christopher R.J. 
Published: October 2017

AbstractOn what basis do we distinguish God from the world? I argue that the doctrine of creation, more specifically the analogical notion of causa, supplies a salutary foundation. My conversation partners are Karl Barth and Thomas Aquinas. I take up the former's five conditions for a right theological use of causa, demonstrating that despite his basic misreading of Thomas, both theologians share some basic convictions regarding God's independence. I argue, moreover, that Thomas provides a more theologically satisfying anchor for what distinguishes God from what is not God. I conclude by reflecting on the importance of experience in articulating the distinction.
Contribution of the β‐glucosidase BglC to the onset of the pathogenic lifestyle of Streptomyces scabies
Authors: Jourdan Samuel , Francis Isolde M. , Deflandre Benoit , Tenconi Elodie , Riley Jennifer , Planckaert Sören , Tocquin Pierre , Martinet Loïc , Devreese Bart , Loria Rosemary , Rigali Sébastien 
Published: October 2017

SummaryCommon scab disease on root and tuber plants is caused by Streptomyces scabies and related species which use the cellulose synthase inhibitor thaxtomin A as the main phytotoxin. Thaxtomin production is primarily triggered by the import of cello‐oligosaccharides. Once inside the cell, the fate of the cello‐oligosaccharides is dichotomized: (i) the fuelling of glycolysis with glucose for the saprophytic lifestyle through the action of β‐glucosidase(s) (BGs); and (ii) elicitation of the pathogenic lifestyle by the inhibition of CebR‐mediated transcriptional repression of thaxtomin biosynthetic genes. Here, we investigated the role of scab57721, encoding a putative BG (BglC), in the onset of the pathogenicity of S. scabies. Enzymatic assays showed that BglC was able to release glucose from cellobiose, cellotriose and all other cello‐oligosaccharides tested. Its inactivation resulted in a phenotype opposite to that expected, as reduced production of thaxtomin was monitored when the mutant was cultivated on medium containing cello‐oligosaccharides as unique carbon source. This unexpected phenotype could be attributed to the highly increased activity of alternative intracellular BGs, probably as a compensation for bglC inactivation, which then prevented cellobiose and cellotriose accumulation to reduce the activity of CebR. In contrast, when the bglC null mutant was cultivated on medium devoid of cello‐oligosaccharides, it instead constitutively produced thaxtomin. This observed hypervirulent phenotype does not fit with the proposed model of the cello‐oligosaccharide‐mediated induction of thaxtomin production, and suggests that the role of BglC in the route to the pathogenic lifestyle of S. scabies is more complex than currently presented.
On Ground as a Guide to Realism
Authors: Atiq Emad H. 
Published: October 2017

AbstractAccording to Fine (among others), a nonbasic factual proposition must be grounded in facts involving those of its constituents that are both real and fundamental. But the principle is vulnerable to several dialectically significant counterexamples. It entails, for example, that a logical Platonist cannot accept that true disjunctions are grounded in the truth of their disjuncts; that a Platonist about mathematical objects cannot accept that sets are grounded in their members; and that a colour primitivist cannot accept that an object's being scarlet grounds its not being chartreuse. The Finean might try to defend these implications, but it generates further problems. Instead, the principle should be rejected. An important upshot is that the principle cannot be relied on to distinguish robust realism from anti‐realism about a propositional domain, for the principle obscures ways of taking features to be both real and fundamental.
Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis
Authors: Osman Kim , Yang Jianhua , Roitinger Elisabeth , Lambing Christophe , Heckmann Stefan , Howell Elaine , Cuacos Maria , Imre Richard , Dürnberger Gerhard , Mechtler Karl , Armstrong Susan , Franklin F. Christopher H. 
Published: October 2017

SummaryDuring meiosis, the formation of crossovers (COs) generates genetic variation and provides physical links that are essential for accurate chromosome segregation. COs occur in the context of a proteinaceous chromosome axis. The transcriptomes and proteomes of anthers and meiocytes comprise several thousand genes and proteins, but because of the level of complexity relatively few have been functionally characterized. Our understanding of the physical and functional interactions between meiotic proteins is also limited. Here we use affinity proteomics to analyse the proteins that are associated with the meiotic chromosome axis protein, ASY1, in Brassica oleracea anthers and meiocytes. We show that during prophase I ASY1 and its interacting partner, ASY3, are extensively phosphorylated, and we precisely assign phosphorylation sites. We identify 589 proteins that co‐immunoprecipitate with ASY1. These correspond to 492 Arabidopsis orthologues, over 90% of which form a coherent protein–protein interaction (PPI) network containing known and candidate meiotic proteins, including proteins more usually associated with other cellular processes such as DNA replication and proteolysis. Mutant analysis confirms that affinity proteomics is a viable strategy for revealing previously unknown meiotic proteins, and we show how the PPI network can be used to prioritise candidates for analysis. Finally, we identify another axis‐associated protein with a role in meiotic recombination. Data are available via ProteomeXchange with identifier PXD006042.
Quantity restrictions and price adjustment of Chinese Textile Exports to the US
Authors: Bernhofen Daniel , Upward Richard , Wang Zheng 
Published: October 2017

AbstractThe elimination of the Multifibre Arrangement (MFA) in 2005 provides an unusual opportunity to examine the effects of a trade policy shock on export prices and firm behaviour. It was massive in scale, discrete in timing and exogenous to firms and consumers in the textile industry. Since the MFA quota removal did not affect all textile products at the same time, we are able to use a difference‐in‐difference approach to estimate the causal effects of the MFA. Using transaction‐level data from the Chinese Customs Trade Statistics over the period 2000–06, we find that the MFA removal reduced average export prices by about 25%. This fall was mainly caused by a combination of the entry of new low‐price exporters and new low‐price products, rather than a fall in prices of existing firm–product combinations. We also find that price reductions are twice as large for heterogeneous than for homogeneous products.
An Advanced Energy Efficient Rack Server Design With Distributed Battery Subsystem
Authors: Wang Chun , Sun Xiaoguang , Zhang Jun , Ahuja Nishi 
Published: October 2017

Data centers concern not just energy usage, but also other important overall considerations such as the actual computational work, the energy efficiency and the performance of servers. The server, as one of the key ingredients of a data center, plays an increasingly crucial role in contributing to the overall energy use, especially in cases where the efficiency of the infrastructure has been optimized. Baidu has been exploring the sweet zone between power and performance in efficient rack server design and deployment for their self-built data center energy efficiency optimization from all the aspects. Recent deployment of rack server with distributed backup battery (Li-ion) subsystem (BBS) is one typical example to demonstrate their advanced rack server design for energy efficiency. Compared with lead acid battery based traditional UPS in data center, distributed BBS design in Baidu rack server has an advantage in lower power loss, data center power delivery and topology simplification, data center real estate saving, scalable deployment on demand without overprovision and so on, which overall contributes to a total cost ownership (TCO) reduction on both cap-ex (i.e., power infrastructure investment) and op-ex (i.e., electricity bill).
This paper introduces overall architecture and design of Baidu rack server with distributed BBS. Furthermore details energy efficiency design methodology of power peak draw trimming based on workload power characterization; Also the related lab data collection, experiments result, ongoing work and future plan are summarized in the end. This paper also recaps TCO saving points benefiting from distributed BBS design into rack server system.
Methods for Theoretical Assessment of Delamination Risks in Electronic Packaging
Authors: Hauck Torsten , Schmadlak Ilko , Lakhera Nishant , Shantaram Sandeep , Samet David , Rambhatla V. N. N. Trilochan , Sitaraman Suresh 
Published: October 2017

Fracture mechanics is an essential field of study towards the improvement and development of electronic packages. In combination with modern simulation method such as finite element analysis (FEA), fracture mechanics is widely used and appreciated in the industry. Many different approaches have been developed to calculate the fracture parameters for interfaces or bulk material under given loads in order to compare them against previously measured failure criteria. While many publications are available that have described the different simulation approaches in detail or compare the different fracture test methods, there have been few comparisons of these simulation approaches with respect to their use in research and development of electronic packages.
The objective of this work is to compare different delamination modeling methodologies and their applications for electronic packaging. The work highlights the differences in theory behind each approach as well as the differences in their practical use to predict delamination or asses a fracture risk in electronic packages. The intention was to use commercially available FE-codes in conjunction with a well-defined set of adhesion strength tests. During this work, energy based fracture criteria were applied by means of the virtual crack closure technique (VCCT), the J-integral and the cohesive zone material model (CZM) methods. These methodologies are most commonly used but can differ significantly from each other as will be shown in this comparison. To demonstrate the use of these techniques, copper lead frame to epoxy mold compound (EMC) delamination was assessed, representing a very common packaging failure mode. Critical energy release rates were measured on multiple Copper-EMC test specimens under varying load phase angles. ANSYS was used to build mechanical simulation models of a selected device. Existing post processing procedures were applied to assess delamination risk based on above mentioned techniques. The simulation study considers realistic monotonic loading conditions and results will also be compared to existing failure analysis images for demonstration and validation purpose. As an outcome, the paper will include a ranking of the approaches as well as a summary of advantages and disadvantages, based method and accuracy. An outlook on future developments such as fatigue or aging phenomena will finish the work.
Transient Thermal Performance of Rear Door Heat Exchanger in Local Contained Environment During Water Side Failure
Authors: Nemati Kourosh , Alissa Husam A. , Tradat Mohammad I. , Sammakia Bahgat 
Published: October 2017

The constant increase in data center computational and processing requirements has led to increases in the IT equipment power demand and cooling challenges of high-density (HD) data centers. As a solution to this, the hybrid and liquid systems are widely used as part of HD data centers thermal management solutions.
This study presents an experimental based investigation and analysis of the transient thermal performance of a stand-alone server cabinet. The total heat load of the cabinet is controllable remotely and a rear door heat exchanger is attached with controllable water flow rate. The cooling performances of two different failure scenarios are investigated. One is in the water chiller and another is in the water pump for the Rear Door Heat eXchanger (RDHX). In addition, the study reports the impact of each scenario on the IT equipment thermal response and on the cabinet outlet temperature using a mobile temperature and velocity mesh (MTVM) experimental tool. Furthermore, this study also addresses and characterizes the heat exchanger cooling performance during both scenarios.
Thermo-Mechanical Study of AlN Thin-Films As Heat Spreaders in III-V Photonic Devices
Authors: Lei Shenghui , Kardemir Ertugrul , McCloskey David , Donegan John F. , Enright Ryan 
Published: October 2017

Ridge-type hybrid III-V active waveguides on silicon-on-insulator (SOI) substrates demonstrate poor thermal performance due to several factors. One aspect of their typical design that leads to large thermal resistance is the use of polymer-based optical cladding around the waveguide. To address this issue, we have been exploring the use of deposited aluminium nitride (AlN) as an alternative optical cladding material. AlN is an excellent dielectric with optical properties making it suitable as a cladding around III-V waveguides. Crucially, this material can demonstrate thermal conductivities ∼100 times larger than current polymer cladding materials such as benzocyclobutene (BCB). Electro-thermo simulation results suggest that replacing BCB with AlN could reduce device thermal resistance by ∼2 times. However, our previous linear elastic mechanical modelling indicates that mismatched thermal expansion has the potential to cause mechanical tensile failure in the III-V waveguide when cooled from the processing temperature to room temperature if AlN is deposited in a neutral residual stress state.
Here, to facilitate the design of encapsulated reliable hybrid semiconductor lasers, we extend our finite element, electro-thermo-mechanical model to include a residual stress in the deposited AlN. Using the Christensen criterion to define the maximum allowable stress in the device, our simulations indicate that there is a window of residual compressive stress in the AlN where mechanical failure may be avoided. To assess the feasibility of accessing this region of compressive residual stress while maintaining suitable thermal properties in the deposited AlN, we measure the thermal conductivity of AlN thin films (∼1.6 μm thick) deposited on silicon using a time-domain thermo reflectance (TDTR) setup. Stress measurements demonstrate compressive residual stresses ranging from ∼0 to −0.5 GPa. The TDTR measurement results reveal a similar thermal conductivity of ∼155 Wm−1K−1 over the entire range of compressive residual stress. These results strengthen the promise of encapsulating III-V active waveguides with AlN that simultaneously satisfy both thermal and mechanical requirements.
Abundance and Multilocus Sequence Analysis of Vibrio Bacteria Associated with Diseased Elkhorn Coral (Acropora palmata) of the Florida Keys
Authors: Kemp Keri M. , Westrich Jason R. , Alabady Magdy S. , Edwards Martinique L. , Lipp Erin K. 
Published: October 2017

ABSTRACT

The critically endangered elkhorn coral (
Acropora palmata
) is affected by white pox disease (WPX) throughout the Florida Reef Tract and wider Caribbean. The bacterium
Serratia marcescens
was previously identified as one etiologic agent of WPX but is no longer consistently detected in contemporary outbreaks. It is now believed that multiple etiologic agents cause WPX; however, to date, no other potential pathogens have been thoroughly investigated. This study examined the association of
Vibrio
bacteria with WPX occurrence from August 2012 to 2014 at Looe Key Reef in the Florida Keys, USA. The concentration of cultivable
Vibrio
was consistently greater in WPX samples than in healthy samples. The abundance of
Vibrio
bacteria relative to total bacteria was four times higher in samples from WPX lesions than in adjacent apparently healthy regions of diseased corals based on quantitative PCR (qPCR). Multilocus sequence analysis (MLSA) was used to assess the diversity of 69
Vibrio
isolates collected from diseased and apparently healthy
A. palmata
colonies and the surrounding seawater.
Vibrio
species with known pathogenicity to corals were detected in both apparently healthy and diseased samples. While the causative agent(s) of contemporary WPX outbreaks remains elusive, our results suggest that
Vibrio
spp. may be part of a nonspecific heterotrophic bacterial bloom rather than acting as primary pathogens. This study highlights the need for highly resolved temporal sampling
in situ
to further elucidate the role of
Vibrio
during WPX onset and progression.

IMPORTANCE
Coral diseases are increasing worldwide and are now considered a major contributor to coral reef decline. In particular, the Caribbean has been noted as a coral disease hot spot, owing to the dramatic loss of framework-building acroporid corals due to tissue loss diseases. The pathogenesis of contemporary white pox disease (WPX) outbreaks in
Acropora palmata
remains poorly understood. This study investigates the association of
Vibrio
bacteria with WPX.
Genomes of Novel Microbial Lineages Assembled from the Sub-Ice Waters of Lake Baikal
Authors: Cabello-Yeves Pedro J. , Zemskaya Tamara I. , Rosselli Riccardo , Coutinho Felipe H. , Zakharenko Alexandra S. , Blinov Vadim V. , Rodriguez-Valera Francisco 
Published: October 2017

ABSTRACT

We present a metagenomic study of Lake Baikal (East Siberia). Two samples obtained from the water column under the ice cover (5 and 20 m deep) in March 2016 have been deep sequenced and the reads assembled to generate metagenome-assembled genomes (MAGs) that are representative of the microbes living in this special environment. Compared with freshwater bodies studied around the world, Lake Baikal had an unusually high fraction of
Verrucomicrobia
. Other groups, such as
Actinobacteria
and
Proteobacteria
, were in proportions similar to those found in other lakes. The genomes (and probably cells) tended to be small, presumably reflecting the extremely oligotrophic and cold prevalent conditions. Baikal microbes are novel lineages recruiting very little from other water bodies and are distantly related to other freshwater microbes. Despite their novelty, they showed the closest relationship to genomes discovered by similar approaches from other freshwater lakes and reservoirs. Some of them were particularly similar to MAGs from the Baltic Sea, which, although it is brackish, connected to the ocean, and much more eutrophic, has similar climatological conditions. Many of the microbes contained rhodopsin genes, indicating that, in spite of the decreased light penetration allowed by the thick ice/snow cover, photoheterotrophy could be widespread in the water column, either because enough light penetrates or because the microbes are already adapted to the summer ice-less conditions. We have found a freshwater SAR11 subtype I/II representative showing striking synteny with
Pelagibacter
ubique
strains, as well as a phage infecting the widespread freshwater bacterium
Polynucleobacter
.

IMPORTANCE
Despite the increasing number of metagenomic studies on different freshwater bodies, there is still a missing component in oligotrophic cold lakes suffering from long seasonal frozen cycles. Here, we describe microbial genomes from metagenomic assemblies that appear in the upper water column of Lake Baikal, the largest and deepest freshwater body on Earth. This lake is frozen from January to May, which generates conditions that include an inverted temperature gradient (colder up), decrease in light penetration due to ice, and, especially, snow cover, and oligotrophic conditions more similar to the open-ocean and high-altitude lakes than to other freshwater or brackish systems. As could be expected, most reconstructed genomes are novel lineages distantly related to others in cold environments, like the Baltic Sea and other freshwater lakes. Among them, there was a broad set of streamlined microbes with small genomes/intergenic spacers, including a new nonmarine
Pelagibacter
-like (subtype I/II) genome.
Complete Genome Sequence of West Nile Virus (WNV) from the First Human Case of Neuroinvasive WNV Infection in Cyprus
Authors: Richter Jan , Tryfonos Christina , Tourvas Aristomenis , Floridou Dora , Paphitou Niki I. , Christodoulou Christina 
Published: October 2017

ABSTRACT
We report here the complete genome sequence of a West Nile virus (WNV) strain from the first laboratory-confirmed human case of neuroinvasive WNV infection in Cyprus. Phylogenetic analysis showed that this WNV strain grouped clearly into genetic lineage 1, clade 1a, cluster 2.