bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjoint-based shape optimization for compressible flow based on volume penalization method
Authors: Liu Ming , Hasegawa Yosuke 
Published: September 2024

AbstractReducing the resistance of compressible flow around a blunt body is of great interest in engineering applications, while an efficient shape optimization method for compressible flows remains far from well established, especially for high Mach numbers. To this end, a volume penalization method for simulating compressible flows past a no-slip and isothermal solid is established by introducing an artificial body force and a heat sink into the governing equations. The level-set functions are introduced as design variables, and the cost functional is defined as the total drag acting on the solid. Then, a continuous adjoint-based shape optimization algorithm for drag reduction is developed by deriving the adjoint equations, the adjoint boundary conditions, and the shape update formula. Both the forward and adjoint simulations are verified by existing studies. The results show that the relative deviations of the drag coefficients obtained in the present study from those reported in the reference studies are around 5% at most, and also a comparable drag reduction rate and also optimal shapes can be reproduced by the present optimization scheme for benchmark problems at relatively low Mach numbers considered in previous studies. Finally, the present method is applied to shape optimization of an initially two-dimensional cylinder and also a three-dimensional sphere in the transonic regime of Ma∞ = 1.2. The drag reduction of over 20% is achieved for both two-dimensional and three-dimensional cases.
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion
Authors: Braczko Felix , Skyschally Andreas , Lieder Helmut , Kather Jakob Nikolas , Kleinbongard Petra , Heusch Gerd 
Published: September 2024

AbstractInfarct size (IS) is the most robust end point for evaluating the success of preclinical studies on cardioprotection. The gold standard for IS quantification in ischemia/reperfusion (I/R) experiments is triphenyl tetrazolium chloride (TTC) staining, typically done manually. This study aimed to determine if automation through deep learning segmentation is a time-saving and valid alternative to standard IS quantification. High-resolution images from TTC-stained, macroscopic heart slices were retrospectively collected from pig experiments (n = 390) with I/R without/with cardioprotection to cover a wide IS range. Existing IS data from pig experiments, quantified using a standard method of manual and subsequent digital labeling of film-scan annotations, were used as reference. To automate the evaluation process with the aim to be more objective and save time, a deep learning pipeline was implemented; the collected images (n = 3869) were pre-processed by cropping and labeled (image annotations). To ensure their usability as training data for a deep learning segmentation model, IS was quantified from image annotations and compared to IS quantified using the existing film-scan annotations. A supervised deep learning segmentation model based on dynamic U-Net architecture was developed and trained. The evaluation of the trained model was performed by fivefold cross-validation (n = 220 experiments) and testing on an independent test set (n = 170 experiments). Performance metrics (Dice similarity coefficient [DSC], pixel accuracy [ACC], average precision [mAP]) were calculated. IS was then quantified from predictions and compared to IS quantified from image annotations (linear regression, Pearson’s r; analysis of covariance; Bland–Altman plots). Performance metrics near 1 indicated a strong model performance on cross-validated data (DSC: 0.90, ACC: 0.98, mAP: 0.90) and on the test set data (DSC: 0.89, ACC: 0.98, mAP: 0.93). IS quantified from predictions correlated well with IS quantified from image annotations in all data sets (cross-validation: r = 0.98; test data set: r = 0.95) and analysis of covariance identified no significant differences. The model reduced the IS quantification time per experiment from approximately 90 min to 20 s. The model was further tested on a preliminary test set from experiments in isolated, saline-perfused rat hearts with regional I/R without/with cardioprotection (n = 27). There was also no significant difference in IS between image annotations and predictions, but the performance on the test set data from rat hearts was lower (DSC: 0.66, ACC: 0.91, mAP: 0.65). IS quantification using a deep learning segmentation model is a valid and time-efficient alternative to manual and subsequent digital labeling.
What every paediatrician needs to know about mechanical ventilation
Authors: ter Horst Jeroen , Rimensberger Peter C. , Kneyber Martin C. J. 
Published: September 2024

AbstractInvasive mechanical ventilation (MV) is one of the most practiced interventions in the intensive care unit (ICU) and is unmistakably lifesaving for children with acute respiratory failure (ARF). However, if delivered inappropriately (i.e. ignoring the respiratory system mechanics and not targeted to the need of the individual patient at a specific time point in the disease trajectory), the side effects will outweigh the benefits. Decades of experimental and clinical investigations have resulted in a better understanding of three important detrimental effects of MV. These are ventilation-induced lung injury (VILI), patient self-inflicted lung injury (P-SILI), and ventilation-induced diaphragmatic injury (VIDD). VILI, P-SILI, and VIDD have in common that they occur when there is either too much or too little ventilatory assistance.Conclusion: The purpose of this review is to give the paediatrician an overview of the challenges to prevent these detrimental effects and titrate MV to the individual patient needs.
Allogenic haematopoietic stem cell transplantation in VEXAS: A review of 33 patients
Authors: Ali Syed B. , Gurnari Carmelo 
Published: September 2024

AbstractVacuolation, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a multisystem disease due to a genetic mutation in the ubiquitin-activating enzyme (UBA1). Allogeneic haematopoietic stem cell transplantation (allo-HSCT) offers both therapeutic and cure but also carries significant risks. A review of VEXAS and HSCT cases was undertaken. Thirty-three patients were identified; majority males (n = 32, 97.0%), median time from symptoms to HSCT: 3 years (IQR 2.0–4.8) and median age of 59 years (IQR 52.5–65.5). UBA1 mutation Met41Thr was most common (11/32, 34.4%). The median variant allele frequency was 56.5% (IQR 43.0–73.5) with no correlation with increasing age. Prior to HSCT, 4.5 (IQR 2.8–6) treatments were trialled. Peripheral blood HSCT (30/31, 96.8%) and HLA-matched, unrelated donor (18/32, 56.3%) were most common. Conditioning regimens varied, with reduced intensity treatment with fludarabine as a co-agent most frequently administered (12/31, 38.7%). Both acute and/or chronic GVHD (18/32, 56.3%) and infections were common (12/32, 37.5%). Overall, 27 individuals (81.8%) were alive, and those undergoing HSCT prospectively had median follow up of 9 months (IQR 3.8–14.4). Of the six deceased, infection was implicated in four. In 11 cases with post-HSCT molecular data, a complete eradication of UBA1 mutation was reported. In summary, while consensus treatment strategy regarding VEXAS is lacking, this review highlights HSCT may remain not only a therapeutic option but also enable cure. However, considerations regarding comorbidities, concurrent haematological disorders as well as overall risks of GVHD and infections need to be made.

Key points• Very few reported prospective cases of VEXAS and allogeneic haematopoietic stem cell transplantation (allo-HSCT) have been reported.• While risks of graft versus host disease and infection remain barriers, this treatment modality remains an option for selected patients.• Allo-HSCT is the only treatment strategy which can remove the UBA1 mutation.
Analytical modeling of piezoelectric meta-beams with unidirectional circuit for broadband vibration attenuation
Authors: Mao Jiawei , Gao Hao , Zhu Junzhe , Gao Penglin , Qu Yegao 
Published: September 2024

AbstractBroadband vibration attenuation is a challenging task in engineering since it is difficult to achieve low-frequency and broadband vibration control simultaneously. To solve this problem, this paper designs a piezoelectric meta-beam with unidirectional electric circuits, exhibiting promising broadband attenuation capabilities. An analytical model in a closed form for achieving the solution of unidirectional vibration transmission of the designed meta-beam is developed based on the state-space transfer function method. The method can analyze the forward and backward vibration transmission of the piezoelectric meta-beam in a unified manner, providing reliable dynamics solutions of the beam. The analytical results indicate that the meta-beam effectively reduces the unidirectional vibration across a broad low-frequency range, which is also verified by the solutions obtained from finite element analyses. The designed meta-beam and the proposed analytical method facilitate a comprehensive investigation into the distinctive unidirectional transmission behavior and superb broadband vibration attenuation performance.
Elastic wave insulation and propagation control based on the programmable curved-beam periodic structure
Authors: Mao Jiajia , Cheng Hong , Ma Tianxue 
Published: September 2024

AbstractCurved-beams can be used to design modular multistable metamaterials (MMMs) with reprogrammable material properties, i.e., programmable curved-beam periodic structure (PCBPS), which is promising for controlling the elastic wave propagation. The PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap, analyze the wave propagation mechanisms, and further form its geometrical and physical criteria for tuning the elastic wave propagation. With the equivalent model, we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability, and investigate the wave propagation characteristics through the PCBPS. To validate the equivalent system, the finite element method (FEM) is employed. It is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical characteristics. The findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control.
Nonlinear metamaterial enabled aeroelastic vibration reduction of a supersonic cantilever wing plate
Authors: Sheng Peng , Fang Xin , Yu Dianlong , Wen Jihong 
Published: September 2024

AbstractThe violent vibration of supersonic wings threatens aircraft safety. This paper proposes the strongly nonlinear acoustic metamaterial (NAM) method to mitigate aeroelastic vibration in supersonic wing plates. We employ the cantilever plate to simulate the practical behavior of a wing. An aeroelastic vibration model of the NAM cantilever plate is established based on the mode superposition method and a modified third-order piston theory. The aerodynamic properties are systematically studied using both the timedomain integration and frequency-domain harmonic balance methods. While presenting the flutter and post-flutter behaviors of the NAM wing, we emphasize more on the pre-flutter broadband vibration that is prevalent in aircraft. The results show that the NAM method can reduce the low-frequency and broadband pre-flutter steady vibration by 50%–90%, while the post-flutter vibration is reduced by over 95%, and the critical flutter velocity is also slightly delayed. As clarified, the significant reduction arises from the bandgap, chaotic band, and nonlinear resonances of the NAM plate. The reduction effect is robust across a broad range of parameters, with optimal performance achieved with only 10% attached mass. This work offers a novel approach for reducing aeroelastic vibration in aircraft, and it expands the study of nonlinear acoustic/elastic metamaterials.
Local resonance metamaterial-based integrated design for suppressing longitudinal and transverse waves in fluid-conveying pipes
Authors: Han Donghai , Jia Qi , Gao Yuanyu , Jin Qiduo , Fang Xin , Wen Jihong , Yu Dianlong 
Published: September 2024

AbstractTo solve the problem of low broadband multi-directional vibration control of fluid-conveying pipes, a novel metamaterial periodic structure with multi-directional wide bandgaps is proposed. First, an integrated design method is proposed for the longitudinal and transverse wave control of fluid-conveying pipes, and a novel periodic structure unit model is constructed for vibration reduction. Based on the bandgap vibration reduction mechanism of the acoustic metamaterial periodic structure, the material parameters, structural parameters, and the arrangement interval of the periodic structure unit are optimized. The finite element method (FEM) is used to predict the vibration transmission characteristics of the fluid-conveying pipe installed with the vibration reduction periodic structure. Then, the wave/spectrum element method (WSEM) and experimental test are used to verify the calculated results above. Lastly, the vibration attenuation characteristics of the structure under different conditions, such as rubber material parameters, mass ring material, and fluid-structure coupling effect, are analyzed. The results show that the structure can produce a complete bandgap of 46 Hz–75 Hz in the low-frequency band below 100 Hz, which can effectively suppress the low broadband vibration of the fluid-conveying pipe. In addition, a high damping rubber material is used in the design of the periodic structure unit, which realizes the effective suppression of each formant peak of the pipe, and improves the vibration reduction effect of the fluid-conveying pipe. Meanwhile, the structure has the effect of suppressing both bending vibration and longitudinal vibration, and effectively inhibits the transmission of transverse waves and longitudinal waves in the pipe. The research results provide a reference for the application of acoustic metamaterials in the multi-directional vibration control of fluid-conveying pipes.
Virtues of routine suprahyoid release during tracheal resection and anastomosis in patients with post intubation stenosis
Authors: Elsayed Hany Hasan , El-Nori Ahmed Anwar , Mostafa Ahmed , Elsayegh Mohamed Tarek , Bassiouny Samia , Refaat Ahmed , Elkahely Mohamed Attia , Zaki Mina 
Published: September 2024

AbstractPostintubation tracheal stenosis is the most common cause of benign tracheal stenosis. Surgical treatment is more challenging in long-segment stenosis. Suprahyoid release can increase tracheal length resected without anastomotic tension in patients with post-intubation tracheal stenosis. Its effect on swallowing has not been objectively studied and this article aims to explore its virtues and potential complications in a tertiary center for airway surgery. A prospective cohort study was conducted on forty consecutive patients from June 2020 till December 2023. Patients of both genders had tracheal resection anastomosis surgery with routine suprahyoid muscle release for resected tracheal segment of more than 2.5 cm in length aiming to decrease the anastomotic tension. Within two weeks postoperatively, a video naso-laryngoscope was done on all the patients to detect any vocal cord disorders, then they were examined by video fluoroscopy swallowing study VFSS to detect swallowing problems. Follow up was done for 6 months postoperatively. 40 patients were studied. Twenty-five patients (62.5%) were males. 21 patients (52.5%) had a cricotracheal resection. VFSS was performed on 38 patients (two patients excluded for serious morbidity). Six (15.7%) and four (10.5%) patients had residual semisolid and solid food in the vallecula and pyriform fossa respectively during swallowing. Five patients (13%) out of eight patients with abnormal VFSS had aspiration and dysphagia. Video nasolaryngoscopy was done pre- and post-operatively and showed that 7 patients (17.5%) had unilateral vocal cord paralysis, two of them had the same lesion preoperatively. Two patients developed postoperative anastomotic complications. All symptoms of dysphagia improved within 3 weeks of the procedure and improvement persisted for 6 months. Suprahyoid muscle release had a considerable reversible drawback on the process of swallowing. Its routine use in high-risk patients requiring long segment tracheal resections could be considered.
Engineered Cancer Nanovaccines: A New Frontier in Cancer Therapy
Authors: Wang Yijie , Liu Congrui , Fang Chao , Peng Qiuxia , Qin Wen , Yan Xuebing , Zhang Kun 
Published: September 2024

AbstractVaccinations are essential for preventing and treating disease, especially cancer nanovaccines, which have gained considerable interest recently for their strong anti-tumor immune capabilities. Vaccines can prompt the immune system to generate antibodies and activate various immune cells, leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and surgery. To enhance the flexibility and targeting of vaccines, nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level, enabling more controlled and precise drug delivery to enhance immune responses. Cancer nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within nanomaterials. The small size of these nanomaterials allows for precise targeting of T cells, dendritic cells, or cancer cells, thereby eliciting a more potent anti-tumor response. In this paper, we focus on the classification of carriers for cancer nanovaccines, the roles of different target cells, and clinically tested cancer nanovaccines, discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation, while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.
Mesomorphic thermal stabilities and nonlinear optical properties of fluorine containing liquid crystals
Authors: Kumari P. Preethi , Bhattacharjee Debanjan , Sonali M. K. , Nayak Sandesha , Moorkoth Sudheer , Gupta Ashutosh , Angadiyavar Priya , Bhagavath Poornima 
Published: September 2024

AbstractH-bonded liquid crystals (HBLCs) are newly synthesized with PyBF viz., (4-pyridyl)-benzylidene-4′-fluoro aniline as the proton acceptor which is non-mesogenic and alkyloxy benzoic acids viz., nOBAs (n = 3, 12) as the mesogenic proton donors. The H-bond formed is confirmed by FTIR spectroscopy. Polarizing Optical Microscopy confirmed the H-bonded compound’s mesomorphic textures, and the thermal analysis is carried out using a Differential Scanning Calorimeter. The influence of fluorine atom on mesomorphic stability is studied. The nonlinear optical properties of the H-bonded compound is studied using DFT theoretical approach. This work supports the SDG-9 of the United Nations.
Graphical abstract
Gram-Negative Colonization and Bacterial Translocation Drive Neonatal Sepsis in the Indian Setting
Authors: Iqbal Faiza , Barche Apurv , Shenoy Padmaja A. , Lewis Leslie Edward S. , Purkayastha Jayashree , Vandana K. E. 
Published: September 2024

Abstract
Background
The gut microbiota, comprising billions of microorganisms, plays a pivotal role in health and disease. This study aims to investigate the effect of sepsis on gut microbiome of neonates admitted to the Neonatal Intensive Care Unit.

Methods
A prospective cohort study was carried out in the NICU of tertiary care hospital in Karnataka, India, from January 2021 to September 2023. Preterm neonates with birth weight < 1500 g and gestational age < 37 weeks were recruited, excluding those with congenital gastrointestinal anomalies, necrotizing enterocolitis, or blood culture-negative infections. The study population was divided into three groups: healthy neonates (Group A), neonates with drug-sensitive GNB sepsis (Group B), and neonates with pan drug-resistant GNB sepsis (Group C). Stool samples were collected aseptically, snapped in liquid nitrogen, and stored at -80⁰C for extraction of DNA and microbiome analysis.

Results
The gut microbiota of healthy neonates (Group A) was dominated by Proteobacteria (24.04%), Actinobacteria (27.13%), Firmicutes (12.74%), and Bacteroidetes (3%). Predominant genera included Bifidobacterium (55.17%), Enterobacter (12.55%), Enterococcus (50.69%), Streptococcus (7.92%), and Bacteroides (3.58%).Groups B and C, the microbiota exhibited higher Proteobacteria abundance (57.16% and 66.58%, respectively) and reduced diversity of beneficial bacteria. Notably, the presence of sepsis was associated with an increase in pathogenic bacteria and a decrease in beneficial commensal bacteria.

Conclusion
Neonates with sepsis exhibited significant gut microbiome dysbiosis, characterized by increased Proteobacteria and reduced beneficial bacteria diversity. These findings highlight the potential of microbiome profiling as a diagnostic tool and underscore the importance of gut microbiota modulation in managing neonatal sepsis.
The Shadow Prices of Voluntary Caregiving: Using Well-Being Panel Data to Estimate the Cost of Informal Care
Authors: McDonald Rebecca , Powdthavee Nattavudh 
Published: September 2024

Abstract
This article uses the well-being valuation (WV) approach to estimate and monetize the well-being impacts of informal care provision on caregivers. Using nationally representative longitudinal data from the UK, the British Household Panel Survey, we address two challenging methodological issues related to the economic valuation of informal care: (i) the anticipatory nature of informal care; and (ii) the sensitivity of income estimates used in valuation. We address the anticipatory issue by focusing on well-being impacts associated with caring for a relative who had recently suffered a serious accident. We use the fixed effects filtered (FEF) estimator to estimate a “time-invariant income” coefficient free from individual fixed effects bias, which helps to partially improve the quality of the income estimate as an alternative to using instrumental variables. This estimate is used in the calculation of shadow prices of informal care. Our estimates suggest that, focusing on the first year of unanticipated care provision, those experiencing the well-being losses from providing unanticipated informal care would be willing to pay approximately £13,167 on average to avoid it.
Provocation and the Reasonable Asian: Applying the Reasonable Person Standard to Asian Defendants Asserting the Provocation Defense
Authors: Hyun Kaitlyn 
Published: September 2024

AbstractThis Article examines the criminal law defense of provocation in the U.S., which employs an objective reasonable person standard, as applied to recent Asian immigrants. It discusses approaches taken in other countries and describes the cultural defense. The Article concludes with different possibilities for a hypothetical Asian defendant who was provoked: Improving education about U.S. laws as a preventative measure, using expert cultural witnesses at trial, and taking the defendant’s characteristics into consideration during the sentencing stage.
The Public Trust as an International Solution to Climate Inaction
Authors: LoPreiato Elizabeth 
Published: September 2024

AbstractThe public trust doctrine holds promise as a tool for combatting international climate inaction. A global public trust in the Earth’s atmosphere may be a feasible avenue for generating international cooperation in this issue. The public trust doctrine is a viable and underutilized mechanism of understanding our collaborative obligations with respect to natural resources. This Article looks to the historical origins and current presentations of public trusts to extract features which indicate its effectiveness and appeal for modern climate change applications. Additionally, it presents two circumstances under which a global public trust in the atmosphere could eventually develop.