bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cross-sectional study to assess any possible linkage of C/T polymorphism in CYP17A1 gene with insulin resistance in non-obese women with polycystic ovarian syndrome
Authors: Banerjee Ushasi , Dasgupta Anindya , Khan Aparna , Ghosh Mrinal Kanti , Roy Pranab , Rout Jayanta Kumar , Roy Priyankar , Dhara Suparna 
Published: October 2016

Background & objectives:
Insulin resistance (IR) is a major confounding factor in polycystic ovarian syndrome (PCOS) irrespective of obesity. Its exact mechanism remains elusive till now. C/T polymorphism in the -34 promoter region of the CYP17 gene is inconsistently attributed to elucidate the mechanism of IR and its link to hyperandrogenemia in obese PCOS patients. In the present study we aimed to evaluate any association of this polymorphism with IR in non-obese women with PCOS.

Methods:
Polymorphism study was performed by restriction fragment length polymorphism (RFLP) analysis of the Msp A1 digest of the PCR product of the target gene in 75 PCOS cases against 73 age and BMI matched control women. Serum testosterone, BMI and HOMA-IR (homeostatic model of assessment-insulin resistance) were analyzed by standard techniques. A realistic cut-off value for the HOMA-IR was obtained through receiver operating characteristic (ROC) curve for exploring any possible link between IR and T/C polymorphism in the case group.

Results:
Significant increases in serum testosterone and HOMA-IR values were observed among the case group (P<0.001) without any significant elevation in BMI and FBG compared to controls. Cut-off value for IR in the PCOS patients was 1.40 against a maximum sensitivity of 0.83 and a minimum false positivity of 0.13. The analysis revealed an inconclusive link between the C/T polymorphic distribution and insulin resistant case subjects.

Interpretation & conclusions:
The results showed that CYP17A1 gene was not conclusively linked to either IR or its associated increased androgen secretion in non-obese women with PCOS. We propose that an increased sensitivity of insulin on the ovarian cells may be the predominant reason for the clinical effects and symptoms of androgen excess observed in non-obese PCOS patients in our region.
The making of indigenous vascular prosthesis
Authors: Unnikrishnan Madathipat , Viswanathan Sidharth , Balasubramaniam K. , Muraleedharan C.V. , Lal Arthur Vijayan , Mohanan P.V. , Mohanty Meera , Kapilamoorthy Tirur Raman 
Published: October 2016

Background & objectives:
Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies.

Methods:
The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate) graft at its research wing. Further characterization and testing followed by clinical trials were conducted at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. Fifteen in vivo experiments were carried out in 1992-1994 in pigs as animal model. Controlled (phase I) clinical trial in ten patients was performed along with control graft. Thereafter, phase II trial involved 22 patients who underwent multi-centre clinical trial in four centres across India.

Results:
Laboratory testing showed that polyester graft was non-toxic, non-leeching and non-haemolytic with preserved long-term quality, further confirming in pigs by implanting in thoracic aorta, comparable to control Dacron grafts. Perigraft incorporation and smooth neointima formation which are prime features of excellent healing characteristics, were noted at explantation at planned intervals. Subsequently in the phase I and II clinical trials, all patients had excellent recovery without mortality or device-related adverse events. Patients receiving the test graft were followed up for 10 and 5 years, respectively. Serial clinical, duplex scans and CT angiograms performed periodically confirmed excellent graft performance.

Interpretation & conclusions:
Indigenously developed Chitra vascular graft was comparable to commercially available Dacron graft, ready for clinical use at affordable cost to patients as against costly imported grafts.
“A Strange, Ventriloquous Voice”: Louisiana Creole, Whiteness, and the Racial Politics of Writing Orality
Authors: Gipson Jennifer 
Published: October 2016

Abstract
Documents of nineteenth-century Louisiana Creole folklore have largely been equated with the black Creole-speaker’s voice—and studied separately from white writers’ literary or satirical uses of the language. Building on Jordan and de Caro (1996), who show how early folklore study in Louisiana offered a mechanism of white self-situation, this article considers folklore collection alongside other modes of representing orality in writing. From Reconstruction Era satires or supposed folktales to blackface theater of the 1930s, these texts shape ideologies of language across disciplinary and generic boundaries, racialize orality, enact literacy, and even help to claim the ethnic label Creole as “whites only.”
The Pathology of the Dual-Career Couples: A Qualitative Study
Authors: Gerami Mohammad Hassan , Etemadi Ozra , Ahmadi Sayyed Ahmad , Fatehizade Maryam 
Published: October 2016

<p><strong>INTRODUCTION:</strong> The structure of traditional family was now changing towards the dual-career ones and due to the impacts that dual-career couples have on the structure of the family, it was necessary to investigate these effects from a discovery perspective. On this base, the present study aims to investigate the pathology of the Iranian dual-career couples’ life.</p><p><strong>METHOD:</strong> In terms of methodology, the study was done qualitatively and it was validated by the grounded theory. The participants were dual-career couples in Yazd. The sampling was done purposefully with 24 participants in a half-organized interview. A theoretically codified method and grounded theory were used to analyze and validate data gathered in this respect.</p><p><strong>FINDINGS:</strong> The findings of the study showed that the pathology of the dual-career couples based on three issues and aspects include entity and conceptual and abstract contents. It included A: reasons and elements (career- family and family-career conflicts, the hierarchical order for power and influence, issues and management of financial and economic affairs), B: actions (the responsibility division, the problem of sexual and marital relations in, the issues of child raising and child rearing, decrease of intimacy and the time of being together), and C: consequences (lack of happiness and joy, decrease of the relations with the relatives, nutritional, spiritual and psychological issues).</p><p><strong>CONCLUSION:</strong> Generally, the results of the study showed that dual-career couples’ experience the pathology and conflicts influence their job and these pathologies were presented in the form of a conceptual model.</p>
La terapia de la coherencia: un enfoque constructivista apoyado por la neurociencia contemporánea
Authors: Jasiński Michał , Paz Clara , Feixas Guillem 
Published: October 2016

ResumenEn el presente artículo se describe la terapia de la coherencia (TC). Con el fin de presentar este enfoque se realiza una breve descripción del constructivismo y su influencia tanto en la TC, como en la psicoterapia en general. Se continúa con la explicación detallada de la historia, teoría y metodología de la TC. Se describe también la reconsolidación de la memoria, un fenómeno descubierto recientemente en el campo de la neurociencia que parece ocurrir en el proceso de la TC y se presentan sus implicaciones para la psicoterapia. Se utiliza un breve estudio de caso para explicar el proceso de la TC de forma práctica. Finalmente, se describe el estado acual y el futuro de este enfoque terapéutico. AbstractCoherence therapy (CT) is described in the present article. Constructivism´s influence on psychotherapy in general and on CT specifically is discussed briefly, followed by a detailed presentation of CT´s history, theory and methodology. Memory reconsolidation, a recently discovered phenomenon which is stated to occur in CT process, is described as well together with its implications for psychotherapy field. A brief case study is presented to show CT´s process in prac­tice and the future and limitations of CT are dis­cussed in the final part of the article
Diferencias en función del sexo en la percepción del riesgo asociado al consumo de drogas en jóvenes
Authors: Herruzo Carlos , Lucena Valentina , Ruiz-Olivares Rosario , Raya Antonio , Pino María José 
Published: October 2016

ResumenEl objetivo de este estudio consiste en caracterizar la percepción del riesgo asociado tanto a sustancias legales (alcohol, tabaco e inhalantes) como ilegales (cannabis, cocaína, heroína, anfetaminas, drogas de diseño, alucinógenos) entre los jóvenes de 18 a 29 años en seis dimensiones (problemas para la salud física, salud psíquica, tráfico, capacidad para realizar tareas, relaciones interpersonales y problemas legales) y, además, si existen diferencias de percepciones en función del sexo. Con un diseño ex post facto de grupo único se han estudiado los perfiles perceptivos de 3819 jóvenes andaluces en las nueve drogas citadas. La percepción de los jóvenes muestra patrones diferentes para cada droga, destacando que existen ciertos sesgos los problemas psíquicos derivados del alcohol, que son vistos como menos peligrosos que los problemas de salud o los efectos sobre la salud del cannabis, que se ven como menos peligrosos que los del tabaco. Con respecto a la variable sexo, las mujeres perciben las drogas estudiadas como más peligrosas, salvo el caso de los inhalantes y ciertas dimensiones específicas de otras drogas, en concreto, el riesgo para la salud física en la cocaína, y los accidentes de tráfico y el riesgo para la salud física en el caso de las anfetaminas. Se sugieren enfatizar estos aspectos en las campañas informativas y preventivas. AbstractThe aim of this study was to characterize the perception of the risk associated to both legal substances (alcohol, tobacco and inhalants) as illegal (cannabis, cocaine, heroin, amphetamines, designer drugs, hallucinogens) among youth 18 to 29 years old in six dimensions (problems for the physical health, mental health, traffic, ability to perform tasks, interpersonal relations and legal problems), and also, if weather such perceptions are different by sex. With a ex post facto single group design, were studied the perceptual profiles of 3,819 Andalusian young people about cited drugs. The perceptions of young people show different patterns for each drug, enhancing that there are certain biases about the psychic problems derivatives of alcohol, which are viewed as less dangerous than the problems of health; or the health effects of cannabis, which are seen as less dangerous than the tobacco. With regard to sex variable, women perceive drugs studied as more dangerous, except in the case of inhalants and certain specific dimensions of other drugs, in particular, the risk to the physical health in cocaine, and traffic accidents and the risk to the physical health in the case of amphetamines. Emphasizing these aspects in information campaigns and preventive measures is suggested.
Patrón de Conducta Tipo A y B, y su relación con las adicciones conductuales
Authors: Belmonte Steibel Gisele , Ruiz-Olivares Rosario , Herruzo Cabrera Javier 
Published: October 2016

ResumenEl objetivo de esta investigación fue relacionar el patrón de conducta Tipo A y B (PCTA y PCTB) con la posibilidad de presentar adicciones a Internet, juego, compras y abuso del teléfono móvil en una muestra de jóvenes de la provincia de Córdoba (España). Con un diseño prospectivo expost-facto con dos grupos, se elaboró un cuestionario con el que se recogieron datos sociodemográficos, y en el que se incluyeron otros cuestionarios como el Test de adicción a las compras, el Test de adicción a Internet de Echeburúa (2003), el Cuestionario Breve de Juego Patológico de Fernández-Montalvo, Echeburúa y Baéz (1997); algunos ítems sobre el uso del teléfono móvil; y el cuestionario de PCTA de Jenkins. Participaron 3815 jóvenes de la provincia de Córdoba (España) con un rango de edad entre los 18 y 29 años. Los resultados indican que los jóvenes PCTA son los que más compran, juegan, se conectan a Internet y usan el móvil. En conclusión se puede inferir que los jóvenes con patrón de personalidad Tipo A tienen más posibilidades de presentar conductas adictivas que los jóvenes de patrón de conducta Tipo B. AbstractThis research aimed to relate the possibility of sub­mitting the Type A and the Type B behavior patterns to the no-substance addiction. We investigated the Internet addiction, the gambling, the shopping, and the misuse of mobile in a sample of youth people. With a prospective design ex-post-facto two groups, a questionnaire was developed to collect sociodemo­graphic data, in which we included the Test of Shop­ping Addiction, the Test of Internet Addiction from Echeburúa (2003), the Pathological Gambling Brief Questionnaire from Fernandez-Montalvo Echeburúa y Baez (1997), some items on Mobile Phone Usage, and the Jenkins Activity Survey. Young people from the Province of Córdoba, Spain, have participated (N = 3815, age range between 18 and 29). Results in­dicated that young people characterized as Type A behavior pattern show bigger propension to shop­ping, to playing, to Internet connection, and to use of mo­bile phone. According to logistic regression, The Type B behavior pattern showed to be a protective factor for addiction to shopping. In conclusion it can be inferred that young people of Type A behavior pattern are more likely to have addictive behaviors that young people of Type B behavior pattern.
Novel fully vertical GaN p–n diode on Si substrate grown by metalorganic chemical vapor deposition
Authors: Mase Suguru , Urayama Yuya , Hamada Takeaki , Freedsman Joseph J. , Egawa Takashi 
Published: October 2016

Abstract
We report novel GaN fully vertical p–n diode on Si grown by metalorganic chemical vapor deposition. The thick strained layer superlattice is effective in controlling a doping level of 1016 cm−3 in an n−-GaN drift layer. The GaN p–n diode exhibits a differential on-resistance R
on of 7.4 mΩ cm2, a turn-on voltage of 3.4 V, and a breakdown voltage V
B of 288 V. The corresponding Baliga’s figure of merit (FOM)

is 11.2 MW/cm2. A good FOM value for the GaN-on-Si vertical p–n diode is realized for a drift layer thickness of 1.5 µm without using substrate removal technology.
P‐gp activity and inhibition in the different regions of human intestine ex vivo
Authors: Li Ming , de Graaf Inge A.M. , de Jager Marina H. , Groothuis Geny M.M. 
Published: October 2016

AbstractAlthough intestinal P‐glycoprotein (P‐gp) has been extensively studied in vitro and in animals, its activity and the consequences of P‐gp inhibition for drug disposition and toxicity in humans are still difficult to accurately extrapolate from these studies. Moreover, existing in vitro models do not take into consideration that the intestine is heterogeneous with respect to P‐gp expression. Recently, we reported rat precision‐cut intestinal slices (PCIS) as a physiological ex vivo model to study the regional gradient of P‐gp activity and inhibition. Here we extended the application of PCIS to the human intestine. For this purpose rhodamine 123 (R123) accumulation in the presence or absence of the P‐gp inhibitors verapamil, cyclosporine A, quinidine, ketoconazole, PSC833 and CP100356 was measured in PCIS of human duodenum, jejunum, ileum and colon. R123 accumulation in the presence of the P‐gp inhibitors appeared to be most enhanced in the ileum compared to the other regions. Moreover, the regional differences in accumulation are in line with published differences in abundance of P‐gp. The rank order of the potency of the P‐gp inhibitors, reflected by their IC50, was comparable to that in rat PCIS. However, the increase in accumulation of the P‐gp substrate R123 by the inhibitors was larger in human ileum PCIS than in rat PCIS, indicating species difference in P‐gp abundance. These data show that human PCIS are an appropriate ex vivo model to study the activity of intestinal P‐gp and predict the inhibitory effect of drugs and of transporter‐mediated drug‐drug interactions in the human intestine. Copyright © 2016 John Wiley & Sons, Ltd.
The (Un)reliability of Alibi Corroborators: Failure to Recognize Faces of Briefly Encountered Strangers Puts Innocent Suspects at Risk
Authors: Charman Steve D. , Reyes Andrea , Villalba Daniella K. , Evans Jacqueline R. 
Published: October 2016

AbstractSome innocent suspects rely on the memory of strangers to corroborate their alibis. However, no research has examined whether such potential alibi corroborators can accurately recognize an innocent suspect with whom they previously interacted. We developed a novel alibi corroboration paradigm in which undergraduate students (representing innocent suspects who would later provide an alibi) interacted with naïve university employees (representing potential alibi corroborators). Each student briefly interacted with a different naïve university employee (n = 60), and were also each yoked to a different employee with whom they did not interact (n = 60). Employees were presented 24 hours later with either a single photograph of the student or a six‐person array containing a photograph of the student and were asked if they recognized anyone. The majority of employees failed to make a correct recognition of the student. False recognitions, however, were rare. Students exhibited overconfidence that they would be recognized. Findings imply that innocent suspects who rely on strangers to corroborate their alibis may be at risk. Copyright © 2016 John Wiley & Sons, Ltd.
The Third Rail of Interventional Cardiology: Revascularization of Non‐Infarct‐Related Arteries During Primary PCI
Authors: Safian Robert D. 
Published: October 2016

Key Points

Despite current guidelines, there is expanding evidence for the safety and efficacy of routine multivessel PCI for STEMI patients.
FFR has incremental value for assessing stenosis severity in STEMI patients with multivessel disease.
Further studies of vulnerable plaque are needed to obtain a complete risk assessment in STEMI patients.
Surgical vs. Percutaneous Approaches to Paravalvular Leak: Is Closure Too Little Too Late, or Just Not Soon Enough
Authors: Feldman Ted , Nietlispach Fabian 
Published: October 2016

Key Points

Percutaneous paravalvular leak (PVL) closure has lower procedure mortality than surgical closure in a non‐randomized comparison
Both percutaneous and surgical PVL closure have high long‐term mortality with nearly half of patients dead after 2.5 years
Multivariate analysis showed age, worse NYHA class, and renal failure were associated with worse prognosis
Earlier detection and treatment of PVL should be considered to improve late results
Small Acute Mechanical Circulatory Support Pumps for Small People
Authors: Kapur Navin K. , Esposito Michele 
Published: October 2016

Key Points

Webb and Dimas identify that use of vascular chimney grafts is better than direct cannulation for delivering the Impella 2.5 axial flow pump via the carotid artery in a swine model.
Given the growing demand for acute mechanical circulatory support (AMCS) pumps among pediatric patients, this report highlights vascular access techniques and equipment as a major unmet need for the pediatric population.
New vascular sheaths, grafts, and techniques are required for greater adoption of AMCS devices in pediatric patients.
Cathode Stability Provided by New Electrolyte containing Cyano‐benzimidazole‐based Lithium Salt: Insights From In Situ DRIFTS Analysis
Authors: Teshager Minbale Admas , Hwang Bing‐Joe , Chern Yaw‐Terng , Lin Shawn D. 
Published: October 2016

AbstractNew electrolytes with good thermal and electrochemical stabilities can improve lithium‐ion batteries for applications at high temperatures and high‐potential working conditions. In this study, the solid–electrolyte interphase (SEI) formed in the presence of the new 5‐cyano‐bis(trifluoroborane)‐trifluoromethyl‐benzimidazole lithium salt is examined on two cathodes, that is, commercial LiCoO2 and Li‐rich Li1.2Ni0.2Mn0.6O2 cathodes, using in situ diffuse reflectance infrared Fourier‐transform spectroscopy (DRIFTS). The SEI species contain no decomposition products related to the new electrolyte, up to a potential of 5.0 V. During the first charging process, SEI formation starts at an onset potential of 4.4 or 4.5 V for LiCoO2 or Li1.2Ni0.2Mn0.6O2, respectively, which is higher than that observed by using commercial LiPF6 electrolyte. SEI species of acid anhydride, alkyl carbonates, and Li2CO3 are identified at and beyond the onset potential, which can be attributed to the decomposition of organic carbonates. Furthermore, SEI formation is relatively insignificant in the second‐cycle charging, indicating the formation of a passivating layer in the first cycle, in contrast to the continuing SEI formation through cycling with LiPF6 electrolyte. The different SEI formed with the new electrolyte can be attributed to the adsorption of the electrolyte anion on the electrode surface. This study demonstrates changes in SEI formation chemistry with the new electrolyte, which appears to be a suitable candidate for transition‐metal‐oxide cathodes at high voltage conditions.
Stereodivergent Aminocatalytic Synthesis of Z‐ and E‐Trisubstituted Double Bonds from Alkynals
Authors: Marzo Leyre , Luis‐Barrera Javier , Mas‐Ballesté Rubén , Ruano José Luis García , Alemán José 
Published: October 2016

AbstractA highly diastereoselective synthesis of trisubstituted Z‐ or E‐enals, which are important intermediates in organic synthesis, as well as being present in natural products, is described using different alkynals and nucleophiles as starting materials. Diastereocontrol is mainly governed by the appropriate catalyst. Therefore, those reactions controlled by steric effects, such as the Jørgensen–Hayashi's catalyst, give access to E isomers, and those catalysts that facilitate hydrogen bonding, such as tetrazol‐pyrrolidine Ley's catalyst, allow the synthesis of Z isomers. A stereochemical model based on DFT calculations is proposed.
Solution and Solid‐State Studies on the Halide Binding Affinity of Perfluorophenyl‐Armed Uranyl–Salophen Receptors Enhanced by Anion–π Interactions
Authors: Leoni Luca , Puttreddy Rakesh , Jurček Ondřej , Mele Andrea , Giannicchi Ilaria , Mihan Francesco Yafteh , Rissanen Kari , Dalla Cort Antonella 
Published: October 2016

AbstractThe enhancement of the binding between halide anions and a Lewis acidic uranyl–salophen receptor has been achieved by the introduction of pendant electron‐deficient arene units into the receptor skeleton. The association and the occurrence of the elusive anion–π interaction with halide anions (as tetrabutylammonium salts) have been demonstrated in solution and in the solid state, providing unambiguous evidence on the interplay of the concerted interactions responsible for the anion binding.