bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a function-based IT platform for variants redesign of household appliances
Authors: Peruzzini Margherita , Raffaeli Roberto , Malatesta Marco , Germani Michele 
Published: September 2017

AbstractModular product design is an efficient strategy to let manufacturing companies meet the customers’ requirements by offering a wide variety and customization of products and significantly saving time and cost during engineering and production (Fei et al., 2011). Despite numerous approaches for function modeling and modular product design (Srinivasan et al., 2012; Eckert, 2013; Vermaas, 2013) that have been developed in the last decades, carrying out an efficient product variants’ design process is still an open issue for many manufacturing companies. The proposed approaches offer numerous ways to model information about product functionality, but each approach is useful and particularly well suited for different applications and domains (Summers et al., 2013). The present research compares the existing approaches for product variants design and defines a function-based model to support product design and redesign according to a modular framework, merging qualitative technical issues with business-oriented evaluation. Such a framework has been used to develop a multiuser IT platform, composed of a knowledge-based engine and four different tools to support designers and engineers in product variants creation, management, and configuration, from product functional modeling to cost estimation and life cycle assessment. The proposed model has been tested on industrial cases in the context of household appliances. Experimental results demonstrates that, after a preliminary context analysis and a proper knowledge base creation, such a model supports a more conscious decision-making and promote collaboration within an interdisciplinary design team. Finally, the case study shows the necessity, but in the meanwhile the insufficiency, of a functional decomposition as the only representation viewpoint.
Function in engineering: Benchmarking representations and models
Authors: Summers Joshua D. , Eckert Claudia , Goel Ashok K. 
Published: September 2017

AbstractThis paper presents the requirements and needs for establishing a benchmarking protocol that considers representation characteristics, supported cognitive criteria, and enabled reasoning activities for the systematic comparison of function modeling representations. Problem types are defined as reverse engineering, familiar products, novel products, and single-component systems. As different modeling approaches share elements, a comparison of modeling approaches on multiple levels was also undertaken. It is recommended that researchers and developers of function modeling representations collaborate to define a canonically acceptable set of benchmark tests and evaluations so that clear benefits and weaknesses for the disparate collection of approaches can be compared. This paper is written as a call to action for the research community to begin establishing a benchmarking standard protocol for function modeling comparison purposes. This protocol should be refined with input from developers of the competing approaches in an academically open environment. At the same time, the benchmarking criteria identified should also serve as a guide for validating a modeling approach or analyzing its failure.
An outbreak of mumps with genetic strain variation in a highly vaccinated student population in Scotland
Authors: WILLOCKS L. J. , GUERENDIAIN D. , AUSTIN H. I. , MORRISON K. E. , CAMERON R. L. , TEMPLETON K. E. , DE LIMA V. R. F. , EWING R. , DONOVAN W. , POLLOCK K. G. J. 
Published: September 2017

SUMMARYAn outbreak of mumps within a student population in Scotland was investigated to assess the effect of previous vaccination on infection and clinical presentation, and any genotypic variation. Of the 341 cases, 79% were aged 18–24. Vaccination status was available for 278 cases of whom 84% had received at least one dose of mumps containing vaccine and 62% had received two. The complication rate was 5·3% (mainly orchitis), and 1·2% were admitted to hospital. Genetic sequencing of mumps virus isolated from cases across Scotland classified 97% of the samples as genotype G. Two distinct clusters of genotype G were identified, one circulating before the outbreak and the other thereafter, suggesting the virus that caused this outbreak was genetically different from the previously circulating virus. Whilst the poor vaccine effectiveness we found may be due to waning immunity over time, a contributing factor may be that the current mumps vaccine is less effective against some genotypes. Although the general benefits of the measles–mumps–rubella (MMR) vaccine should continue to be promoted, there may be value in reassessing the UK vaccination schedule and the current mumps component of the MMR vaccine.
Quantifying the decline of the Martial EaglePolemaetus bellicosusin South Africa
Authors: AMAR ARJUN , CLOETE DANIËL 
Published: September 2017

SummaryHuman populations in Africa are growing at a faster rate than in any other region; this growth will exert increasing pressures on the continent’s wildlife resources and declines in wildlife are already being observed. Species occupying higher trophic levels may be amongst the most useful indicators of this pressure and raptorial birds have already proven to be particularly useful in highlighting problems with their environment. The Martial Eagle is an African endemic which is thought to be declining and was recently uplisted to globally Vulnerable, although data on population trends are almost entirely lacking. The Southern African Bird Atlas Project (SABAP) 1 and 2 are citizen science projects that represent a rare opportunity, within an African context, to quantify population changes over a 20-year period. We use data from these surveys to explore changes in reporting rates for this species in South Africa between SABAP 1 (1987–1992) and SABAP 2 (2007–2012) at the scale of quarter-degree grid cells. Previous research suggests that such comparisons accurately reflect changes in breeding numbers for this species. We found an overall decline in reporting rates of c.60%, with more cells showing loss or declines (75%) than those showing colonisation or increases (25%). No differences in reporting rate change were found between provinces, suggesting a relative uniform decline across the country. There were, however, differences between biomes with declines recorded in all biomes apart from Albany Thicket, Succulent Karoo and Fynbos (south-western biomes). Declines differed inside and outside protected areas, with larger declines outside (64%) than inside (42%) protected areas, although even within large protected areas significant declines were observed. These results support the uplisting of the species’ conservation status and suggest that even within protected areas the species is not immune to the drivers of decline.
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy
Authors: Wang Hongsheng , Li Wen , Xu Jing , Zhang Tao , Zuo Dongqing , Zhou Zifei , Lin Binhui , Wang Gangyang , Wang Zhuoying , Sun Wei , Sun Mengxiong , Chang Shimin , Cai Zhengdong , Hua Yingqi 
Published: September 2017

AbstractCombretastatin A-4 (CA-4), a tubulin-depolymerizing agent, shows promising antitumor efficacy and has been under several clinical trials in solid tumors for 10 years. Autophagy has an important pro-survival role in cancer therapy, thus targeting autophagy may improve the efficacy of antitumor agents. N-myc downstream-regulated gene 1 (NDRG1) is a significant stress regulatory gene, which mediates cell survival and chemoresistance. Here we reported that CA-4 could induce cell-protective autophagy, and combination treatment of CA-4 and autophagy inhibitor chloroquine (CQ) exerted synergistic cytotoxic effect on human osteosarcoma (OS) cells. Meanwhile, CA-4 or CQ could increase the expression of NDRG1 independently. We further performed mechanistic study to explore how CA-4 and CQ regulate the expression of NDRG1. Using luciferase reporter assay, we found that CA-4 transcriptionally upregulated NDRG1 expression, whereas CQ triggered colocalization of NDRG1 and lysosome, which subsequently prevented lysosome-dependent degradation of NDRG1. Further, we showed that knockdown of NDRG1 caused the defect of lysosomal function, which accumulated LC3-positive autophagosomes by decreasing their fusion with lysosomes. Moreover, NDRG1 inhibition increased apoptosis in response to combination treatment with CA-4 and CQ. Taken together, our study revealed abrogation of NDRG1 expression sensitizes OS cells to CA-4 by suppression of autophagosome–lysosome fusion. These results provide clues for developing more effective cancer therapeutic strategies by the concomitant treatment with CA-4 and clinical available autophagy inhibitors.
Endocast of the Late Triassic (Carnian) dinosaur Saturnalia tupiniquim: implications for the evolution of brain tissue in Sauropodomorpha
Authors: Bronzati Mario , Rauhut Oliver W. M. , Bittencourt Jonathas S. , Langer Max C. 
Published: September 2017

AbstractThe evolutionary history of dinosaurs might date back to the first stages of the Triassic (c. 250–240 Ma), but the oldest unequivocal records of the group come from Late Triassic (Carnian – c. 230 Ma) rocks of South America. Here, we present the first braincase endocast of a Carnian dinosaur, the sauropodomorph Saturnalia tupiniquim, and provide new data regarding the evolution of the floccular and parafloccular lobe of the cerebellum (FFL), which has been extensively discussed in the field of palaeoneurology. Previous studies proposed that the development of a permanent quadrupedal stance was one of the factors leading to the volume reduction of the FFL of sauropods. However, based on the new data for S. tupiniquim we identified a first moment of FFL volume reduction in non-sauropodan Sauropodomorpha, preceding the acquisition of a fully quadrupedal stance. Analysing variations in FFL volume alongside other morphological changes in the group, we suggest that this reduction is potentially related to the adoption of a more restricted herbivore diet. In this context, the FFL of sauropods might represent a vestigial trait, retained in a reduced version from the bipedal and predatory early sauropodomorphs.
Longitudinal analysis of colon crypt stem cell dynamics in sulindac treated Familial Adenomatous Polyposis patients
Authors: Ma Huiying , Brosens Lodewijk A. A. , Elias Sjoerd G. , Morsink Folkert H. M. , Nijman Isaac J. , Hylind Linda M. , Montgomery Elizabeth A. , Offerhaus G. Johan A. , Giardiello Francis M. , de Leng Wendy W. J. 
Published: September 2017

AbstractThe non-steroidal anti-inflammatory drug sulindac decreases size and number of adenomas after 4-6 months of treatment for familial adenomatous polyposis (FAP) patients. However, the underlying mechanism remains unknown. As stem cells are thought to be the tumor precursor cells, visualizing their behavior is crucial for monitoring tumor progression. Increased tag diversity in inactive genes is indicative of a protracted clonal evolution and consequently, increased risk for tumor formation. Therefore, the effect of sulindac on stem cell dynamics was studied. Normal appearing single crypts were laser microdissected in placebo- and sulindac- treated FAP patient tissue after which the methylation patterns were visualized by Next Generation Sequencing. A significant difference in tag diversity over time was found in the sulindac group compared to the placebo group (*p = 0.018), indicative of a shortened clonal evolution treated sulindac. The rate of change in tag diversity over time was correlated with polyp number change over time. No significant difference over time was observed in the percent methylation when comparing placebo vs sulindac. In conclusion, daily sulindac administration in FAP patients significantly altered colorectal stem cell dynamics, which might explain the chemopreventive action of this drug indicating that tag diversity may be used as a predictive biomarker.
New views on phototransduction from atomic force microscopy and single molecule force spectroscopy on native rods
Authors: Maity Sourav , Ilieva Nina , Laio Alessandro , Torre Vincent , Mazzolini Monica 
Published: September 2017

AbstractBy combining atomic force microscopy (AFM) imaging and single-molecule force spectroscopy (SMFS), we analyzed membrane proteins of the rod outer segments (OS). With this combined approach we were able to study the membrane proteins in their natural environment. In the plasma membrane we identified native cyclic nucleotide-gated (CNG) channels which are organized in single file strings. We also identified rhodopsin located both in the discs and in the plasma membrane. SMFS reveals strikingly different mechanical properties of rhodopsin unfolding in the two environments. Molecular dynamic simulations suggest that this difference is likely to be related to the higher hydrophobicity of the plasma membrane, due to the higher cholesterol concentration. This increases rhodopsin mechanical stability lowering the rate of transition towards its active form, hindering, in this manner, phototransduction.
Ultrasensitive Quantitation of Anti-Phospholipase A2 Receptor Antibody as A Diagnostic and Prognostic Indicator of Idiopathic Membranous Nephropathy
Authors: Zhang Qiuhua , Huang Biao , Liu Xiaobin , Liu Bin , Zhang Yi , Zhang Zhijian , Hua Jia , Fan Yun , Hu Ling , Meng Meijuan , Wu Mian , Wang Liang , Hu Zhigang , Sun Zhuxing 
Published: September 2017

AbstractAnti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful for affirming the diagnosis of idiopathic membranous nephropathy (IMN). Time-resolved fluoroimmunoassay (TRFIA) is highly sensitive and quantitative for measuring serum PLA2R-Ab immunoglobulin (IgG). We measured PLA2R-Ab levels with TRFIA in sera from 172 patients with IMN (n = 69), secondary MN (n = 9), and those with other glomerulonephritis (n = 94) at the time of renal biopsy compared to healthy controls (n = 286). Serum anti-PLA2R-IgG levels in healthy volunteers ranged from 0.09–0.91 mg/L. We set the cutoff value of the anti-PLA2R-IgG titer at 0.91 mg/L, with a sensitivity of 84.06% for diagnosing IMN. Increasing the cut-off value to 2.025 mg/L altered the sensitivity for diagnosing IMN to 71.01%, but with 100% specificity. IMN patients had significantly higher serum anti-PLA2R-IgG levels compared to those with secondary MN. PLA2R-Ab titers negatively correlated with estimated glomerular filtration rate (eGFR). Patinets with high titers had significantly lower serum albumin and eGFR, higher proteinuria and serum creatinine levels, accompanied by a lower complete remission rate. High titers of PLA2R-Ab were associated with poor prognosis of patients with IMN. TRFIA-based quantification of anti-PLA2R-IgG can be a reliable approach for the diagnosis and prognostication of patients with IMN.
Dipstick proteinuria and risk of myocardial infarction and all-cause mortality in diabetes or pre-diabetes: a population-based cohort study
Authors: Wang Jinwei , Li Junjuan , Wang Anxin , Wang Jianli , Yang Yaozheng , Chen Shuohua , Wu Shouling , Zhao Minghui , Guo Xiuhua , Zhang Luxia 
Published: September 2017

AbstractTo evaluate the association between dipstick proteinuria and myocardial infarction (MI) or all-cause mortality, a cohort study was conducted among 16,573 general Chinese population with diabetes or pre-diabetes, which were defined as self-reported history of diabetes or fasting blood glucose ≥5.6 mmol/L or under blood glucose lowering therapy. Proteinuria was detected biennially during 2006–2013 by dipstick test. MI and all-cause mortality were recorded through the end of 2014. Mean age (standard deviation) of study participants was 51.16 (10.63) years, with 82.24% of male. During a median follow-up of 8.03 years, 211 MI and 403 all-cause mortality occurred. Multivariable Cox regression revealed occasional or persistent detection of trace or higher in proteinuria increased the risk of all-cause mortality, with hazard ratios (HRs) of 1.42 (95% confidence intervals [CI]: 1.10, 1.83) and 2.23 (95% CI: 1.66, 3.01), respectively, compared to sustained negative in proteinuria. A time-dependent analysis also revealed the association between degree of proteinuria and all-cause mortality, with HRs of 1.80 (95% CI: 1.31, 2.48) for trace and 3.34 (95% CI: 2.40, 4.65) for one plus or higher in proteinuria, compared to negative. The associations regarding MI lost statistical significance after multivariable adjustment. In conclusion, dipstick proteinuria was associated with an increased risk of MI and all-cause mortality among a general population with diabetes or pre-diabetes.
Derivation and Validation of Shock Index as a parameter for Predicting Long-term Prognosis in Patients with Acute Coronary Syndrome
Authors: Yu Tongtong , Tian Chunyang , Song Jia , He Dongxu , Sun Zhijun , Sun Zhaoqing 
Published: September 2017

AbstractThe objective of this study was to examine whether shock index (SI), defined by ratio of heart rate and systolic blood pressure, can predict long-term prognosis of acute coronary syndrome (ACS) in patients undergoing percutaneous coronary intervention (PCI) and to compare prognostic accuracy of SI with the Global Registry of Acute Coronary Events (GRACE) risk score. This study included individuals from 2 independent cohorts: derivation cohort (n = 2631) and validation cohort (n = 963). In the derivation cohort, we derived that higher admission SI was associated with a greater risk of long-term all-cause mortality [HR = 4.104, 95% CI 1.553 to 10.845, p = 0.004] after adjusting for covariates. We validated this finding in the validation cohort [HR = 10.091, 95% CI 2.205 to 46.187, p = 0.003]. Moreover, admission SI had similar performance to the GRACE score in determining all-cause mortality risk in both cohorts (derivation cohort, admission SI vs. GRACE, z = 1.919, p = 0.055; validation cohort, admission SI vs. GRACE, z = 1.039, p = 0.299). In conclusion, admission SI is an independent predictor of adverse outcome in ACS patients undergoing PCI, and can identify patients at high risk of death. SI and the GRACE score showed similar performance in predicting all-cause mortality, and SI is more readily obtained than the GRACE score.
Fast Fourier single-pixel imaging via binary illumination
Authors: Zhang Zibang , Wang Xueying , Zheng Guoan , Zhong Jingang 
Published: September 2017

AbstractFourier single-pixel imaging (FSI) employs Fourier basis patterns for encoding spatial information and is capable of reconstructing high-quality two-dimensional and three-dimensional images. Fourier-domain sparsity in natural scenes allows FSI to recover sharp images from undersampled data. The original FSI demonstration, however, requires grayscale Fourier basis patterns for illumination. This requirement imposes a limitation on the imaging speed as digital micro-mirror devices (DMDs) generate grayscale patterns at a low refreshing rate. In this paper, we report a new strategy to increase the speed of FSI by two orders of magnitude. In this strategy, we binarize the Fourier basis patterns based on upsampling and error diffusion dithering. We demonstrate a 20,000 Hz projection rate using a DMD and capture 256-by-256-pixel dynamic scenes at a speed of 10 frames per second. The reported technique substantially accelerates image acquisition speed of FSI. It may find broad imaging applications at wavebands that are not accessible using conventional two-dimensional image sensors.
High-throughput targeted screening in triple-negative breast cancer cells identifies Wnt-inhibiting activities in Pacific brittle stars
Authors: Blagodatski Artem , Cherepanov Vsevolod , Koval Alexey , Kharlamenko Vladimir I. , Khotimchenko Yuri S. , Katanaev Vladimir L. 
Published: September 2017

AbstractPro-proliferative oncogenic signaling is one of the hallmarks of cancer. Specific targeting of such signaling pathways is one of the main approaches to modern anti-cancer drug discovery, as opposed to more traditional search for general cytotoxic agents. Natural products, especially from marine sources, represent a largely untapped source of chemical diversity, which so far have mostly been screened for cytotoxicity. Here we present a pioneering pipeline of high-throughput screening of marine-based activities targeted against the Wnt signaling pathway, which is one of the key factors in oncogenic transformation, growth and metastasis in different cancers, including the devastating triple-negative breast cancer (TNBC) currently lacking any targeted therapies. This pipeline consisted of collection and characterization of numerous invertebrates during the SokhoBio expedition to the Kuril Basin in North Pacific, preparation of extracts from these specimen, and their screening in dedicated assays monitoring Wnt signaling in TNBC cells. This approach yielded a number of promising hits, including highly specific anti-Wnt activities targeting multiple levels within the Wnt pathway from Ophiura irrorata and other Pacific brittle stars.
A single question regarding mobility in the World Health Organization quality of life questionnaire predicts 3-year mortality in patients receiving chronic hemodialysis
Authors: Wang Hsiu-Ho , Ho Miao-Chun , Hung Kuan-Yu , Cheng Hui-Teng 
Published: September 2017

AbstractLow quality of life, depression and poor quality of sleep are associated with increased mortality in hemodialysis patients. It is not clear which factor has the highest predictive power and what the core element is to explain the predictability. We thus conducted a prospective cohort study that included 151 hemodialysis adults. Three traits of interest were assessed by World Health Organization Quality of Life questionnaire, an abbreviated version (WHOQOL-BREF), Taiwanese Depression Questionnaire, and Athens Insomnia Scale, respectively. They were followed for more than 3 years and the all-cause mortality was 30.5%. The prevalence of quality of life at the lowest tertile, depression and poor quality of sleep was 19.9%, 43.0% and 74.2%, respectively. Discriminant analysis showed the standardized coefficient of each factor as 0.813, −0.289 and 0.066, indicating the highest discriminating power by quality of life to predict mortality. Question 15 “how well are you able to get around?” in the physical health domain of WHOQOL-BREF independently associated a hazard ratio of mortality 0.623 (95% confidence interval 0.423-0.918). Subjective perception of overall quality of life was more related to psycho-social-environmental factors. In conclusion, mobility is an independent and powerful predictor to long term mortality in patients on chronic hemodialysis.
Decoherence Control of Nitrogen-Vacancy Centers
Authors: Lei Chao , Peng Shijie , Ju Chenyong , Yung Man-Hong , Du Jiangfeng 
Published: September 2017

AbstractQuantum mechanical systems lose coherence through interacting with external environments—a process known as decoherence. Although decoherence is detrimental for most of the tasks in quantum information processing, a substantial degree of decoherence is crucial for boosting the efficiency of quantum processes, for example, in quantum biology and other open systems. The key to the success in simulating those open quantum systems is therefore the ability of controlling decoherence, instead of eliminating it. Motivated by simulating quantum open systems with Nitrogen-Vacancy centers, which has become an increasingly important platform for quantum information processing tasks, we developed a new set of steering pulse sequences for controlling various coherence times of Nitrogen-Vacancy centers; our method is based on a hybrid approach that exploits ingredients in both digital and analog quantum simulations to dynamically couple or decouple the system with the physical environment. Our numerical simulations, based on experimentally-feasible parameters, indicate that decoherence of Nitrogen-Vacancy centers can be controlled externally to a very large extend.