bluuebunny/crossref_metadata_2025_split huggingface dataset:
RENTABILIDADE DA CAFEICULTURA TRADICIONAL NA REGIÃO SUL DE MINAS GERAIS NO PERÍODO DE 1995 A 2004
Authors: Gonçalves Múcio Tosta , Pontes Rodrigo de Almeida , Miranda Alberto Magno Borges 
Published: September 2024

A cafeicultura mineira registrou na ultima década uma sucessio de preços que remuneram a atividade, Chegando a registrar em 2002 o menor preço recebido pelos produtores nos últimos 30 anos. Desta forma, o período de 1995 a 2004 caracterizou-se por uma brutal transferência de tenda dos cafeicultores, e em especial dos produtores de Minas Gerais (o maior produtor nacional), para as empresas internacionais compradoras do produto e para os países consumidores. A partir da análise das condigöes de evolução da produção e da tecnologia adotada pelos produtores tradicionais de café, o presente artigo tem como objetivo analisar a rentabilidade obtida do café do sul de Minas Gerais (maior região produtora do estado). A investigaqäo foi realizada por meio da análise do custo médio de produto, das relações de troca e dos valores de venda do produto, e suas implicações no desempenho econômico de lavouras de café arábica que utilizam um sistema tradicional de produção. Pretende-se através desta análise, sensibilizar as diversas lideranças que representam os segmentos da cadeia de produção do café em Minas Gerais; os poderes públicos, produtores e técnicos envolvidos com a atividade, visando formulação de políticas públicas e privadas, que minimizem a ocorrência dos efeitos danosos ocorridos neste período e sua repetição num futuro próximo.
Performance of GPM-IMERG satellite precipitation for rainfall-runoff modeling in Indonesia
Authors: Hidayah Entin , Saifurridzal Saifurridzal , Wiyono Retno Utami Agung , Widiarti Wiwik Yunarni , Martini Resa , Juliastuti Juliastuti , Riduwan Mohammad 
Published: September 2024

ABSTRACT
Accurate discharge predictions are essential for effective water resource management, including irrigation, drinking water supply, hydropower, reservoir management, environmental flow, and flood assessment. Satellite precipitation data, such as GPM-IMERG, offers a viable solution for estimating river discharge, especially in ungauged or sparsely gauged watersheds. This study evaluates the use of GPM-IMERG data in the HEC-HMS hydrological model to predict discharge in the Mayang Watershed, Jember Regency, Indonesia. The study employs the Arithmetic, Polygon Thiessen, and Isohyet methods to analyze rainfall distribution. Results indicate that the Polygon Thiessen method, when paired with GPM-IMERG data, provides more reliable precipitation estimates due to its consideration of rain gauge proximity. Calibration and validation confirm the superiority of GPM-IMERG data over traditional observational data, particularly under high-flow conditions. Despite some limitations in detecting low-intensity precipitation, GPM-IMERG outperforms other satellite products like TRMM in terms of accuracy. Sensitivity analysis highlights the significant influence of parameters such as curve Number and time of concentration on model outcomes. Further research should explore emerging rainfall data products to improve hydrological modeling accuracy.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome with Multiple Drugs (Leflunomide and Cefuroxime): A Case Report
Authors: Yadav Pooja , Rao Gopal Krishna , Rataboli Padmanabh V. , Gurav Shailendra S. 
Published: September 2024

Background:
Adverse Drug Reactions (ADRs) are unexpected reactions to a medicine
administered in the correct manner and at the proper dosage. Drug Rash with Eosinophilia and
Systemic Symptoms syndrome (DRESS syndrome) is a Severe Cutaneous Adverse Reaction (SCAR)
type of ADR with complicated clinical features involving several organ systems of the
body; frequently involved organs are the liver, kidney, lungs, and other organs. Prompt recognition
and correct diagnosis, followed by withdrawal of the causative agent, can promote appropriate
treatment, accelerate recovery, and reduce the related morbidity and mortality.

Case presentation:
We have, herein, presented a case of a 42-year-old female with a history of leflunomide
intake for plantar fasciitis. The patient subsequently developed fever, gastrointestinal
tract disturbance, facial edema, liver injury, skin rash, hematologic abnormalities (eosinophilia),
hepatosplenomegaly, and lymph node enlargement. The probability of leflunomide-induced
DRESS syndrome was rated as “definite”, with seven scores graded by RegiSCAR. The suspected
causative agent was withdrawn, and the patient was managed symptomatically. Following her management
and discharge, she again encountered similar complaints after administration of the cefuroxime
tablet. The causality assessment of the reactions was done using the WHO-UMC scale
and Naranjo’s assessment scale, and a “probable” reaction was found for both drugs.

Conclusion:
The presented case contributes to the existing global literature regarding exceptional
clinical presentations. Leflunomide and cefuroxime drugs have the potential to cause DRESS syndrome.
Thus, they should be handled cautiously, and if such a reaction occurs, it should be reported
to the responsible authorities.
MGCN-PolyA: An Integrated Computational Framework for Predicting
Poly(A) Signals with Multiscale-gated Convolutional Networks
Authors: Zhuang Jujuan , Gao Wanquan , Huang Xinru , Chen Guoyan 
Published: September 2024

Background:
The accurate recognition of the polyadenylation signal (PAS) from DNA
sequences is essential for understanding gene transcriptional regulation. A variety of machine learning-based computational methods have been developed to predict PAS in recent years; however,
their performance and their generalization ability are unsatisfactory. It is highly desirable to design
more preferable computational approaches for PAS prediction.

Methods:
In this work, we developed an integrated framework MGCN-PolyA for PAS prediction
across four species, including Homo sapiens, Bos taurus, Mus musculus, and Drosophila melanogaster. MGCN-Poly(A) benefits from the diversity of feature engineering and the effectiveness of
the model architecture. We combined features from different perspectives, such as word embedding, One-hot encoding, K-mer frequency, and Enhanced Nucleic Acid Composition (ENAC),
which complement each other and provide rich and comprehensive information for model learning.
In model architecture, MGCN-Poly(A) leverages a two-channel multi-scale gated convolutional
network to effectively learn high-level feature representations at different scales, and then combines
the statistical features to predict PAS using random forest algorithm. These designs not only speed
up network training, but also improves the generalization ability

Results:
The benchmarking experiments on the independent test datasets demonstrate that MGCNPolyA outperforms other state-of-the-art algorithms in identifying PAS. MGCN-PolyA has the
highest accuracy on all test datasets, and its excellent performance on cross-species validation also
demonstrates the robustness of our model.

Conclusion:
Extracting features from different perspectives is important for PAS recognition, and
the integration of DNNs and shallow machine learning algorithms can improve the model performance.
Chemical Identification of Purified Molecule (3-Ethyl-6,7-dihydroxy-2- phenyl-chromen-4-one) Prepared from Alpinia officinarum with Anti- Cryptococcus neoformans Potential
Authors: Nasr Samar , Mahmoud Yehia A.G. , Elsilk Sobhy E. , Salah Ahmed M. , Amin Basma H. 
Published: September 2024

Background:
Plants contain a large number of molecules with various potentials, including antifungal impact. Cryptococcus neoformans (C. neoformans) is a yeast that causes Cryptococcosis infection in both immunocompromised and normal individuals worldwide.

Objective:
This study aimed to investigate the inhibitory impact of plant extracts on C. neofor-mans and perform purification of the most bioactive product for further chemical identifica-tion.

Methods:
The anti-C. neoformans potential of fourteen plants extracted by using various sol-vents, including water, methanol, and benzene, was tested. The most promising compound with anti-C. neoformans was purified. The minimal inhibitory level of the purified sub-frac-tion as compared to fluconazole as a standard drug was determined. The chemical identifica-tion of the purified product was carried out using FTIR, 1HNMR, elemental analysis, and Mass spectroscopy.

Results:
Alpinia officinarum (A. officinarum) methanolic extract has the highest antifungal impact on C. neoformans and showed an inhibition zone of 3.2±0.2 cm. The methanolic ex-tract was separated into 14 fractions, where the fifth fraction showed the highest activity. It was further separated into four sub-fractions that were tested to characterize the most promis-ing molecule with anti-C. neoformans impact, which was further chemically identified as 3-Ethyl-6,7-dihydroxy-2-phenyl-chromen-4-one. The purified product led to significant altera-tions in the ultra-structure of C. neoformans relative to the standard drug.
Antioxidant and Cytoprotective Effects of Different Compounds on Cyclophosphamide-induced Nephrotoxicity
Authors: Almeida Machado Dayane , Moreira de Castro Oliveira Natasha , Speroni Ceron Carla , Tavares do Vale Gabriel 
Published: September 2024

Abstract:
Cyclophosphamide is a drug derived from nitrogenous mustards and is mainly indicated
for the anti-neoplastic clinic. When it is metabolized in the liver, it produces acrolein, a cytotoxic
metabolite capable of generating damage to the body. The oxidative, nitrative and nitrosative
stress are responsible for mediating this side effect since the toxicity of the drug induces the production
of reactive species of oxygen (ROS) and nitrogen (RNS). These radicals are unstable and
react with other molecules that can result in cellular lesions such as lipid peroxidation, enzymatic
inactivation, and excessive activation of pro-inflammatory genes, producing molecules such as
malonaldehyde (MDA) and nitric oxide (NO), representing oxidative stress markers. One of the
consequences of these mechanisms is nephrotoxicity. In contrast, some compounds have direct or
indirect antioxidante action, which are the objects of this study: gallic acid, aminoguanidine,
chrysin, hesperidine, naringin, morin-5'-sulfonic acid sodium salt and spirulina. All of them are responsible
for the nephroprotective activity when administered during experiments in vitro or in
vivo. Thus, this observational bibliographic research is characterized as qualitative descriptive and
explanatory, since it focuses on analyzing the antioxidant properties of compounds with possible
potentials to inhibit the nephrotoxicity induced by cyclophosphamide and describe the results, in
addition to clarifying the biochemical activities involved in the process.
Under Three Heavy Mountains—Identity Construction and Subjectivity Struggle of Chinese Women Workers
Authors: Yu Linhao 
Published: September 2024

This paper examines contemporary Chinese women workers, whose experiences have gained increasing attention as rural labor forces migrate to urban areas and China’s status as the “factory of the world” evolves. It utilizes Pun Ngai’s ethnography “Made in China” as the primary text, alongside supporting texts such as “Rural Women in Urban China” (Jacka, 2006), “The change of factory regime in China and its impacts on workers” (Zhao, 2010). This paper provides a detailed analysis of the construction of these workers’ identities and their struggle for subjectivity. Confronted with triple oppression, female workers navigate and reshape their identities amidst the tensions between urban and rural settings.
Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study
Authors: Hedlund Emma , Tojjar Jasaman , Lilja Lisa , Elding Larsson Helena , Forsander Gun , Ludvigsson Johnny , Marcus Claude , Norström Fredrik , Persson Martina , Carlsson Annelie 
Published: September 2024

OBJECTIVE
To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes.

RESEARCH DESIGN AND METHODS
Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA.

RESULTS
Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P &lt; 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002).

CONCLUSIONS
A family history of T2D and being overweight may contribute to increased risk of T1D.
A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity
Authors: Retnakaran Ravi , Pu Jiajie , Ye Chang , Emery Alexandra , Harris Stewart B. , Reichert Sonja M. , Gerstein Hertzel C. , McInnes Natalia , Kramer Caroline K. , Zinman Bernard 
Published: September 2024

OBJECTIVE
Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed among patients with type 2 diabetes (T2D). However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve β-cell function in early T2D. Thus, for evidence of recovery of glucotoxicity-associated β-cell dysfunction, we sought to determine whether there exists a baseline fasting glucose threshold above which the post-IIT improvement in both β-cell function and glycemia is amplified.

RESEARCH DESIGN AND METHODS
IIT (glargine, lispro) was administered for 3 weeks to 108 adults with T2D (mean duration 1.8 ± 1.4 years). Oral glucose tolerance tests before and after IIT enabled assessment of β-cell function by Insulin Secretion-Sensitivity Index-2 and insulinogenic index/HOMA-insulin resistance. For each level of baseline fasting glycemia from 6.0 to 10.5 mmol/L, we modeled the difference in IIT-induced percentage change in β-cell function between those at/above the indicated glucose level and those below it.

RESULTS
The relationship between baseline fasting glucose and the differential change in β-cell function was nonlinear. Instead, this relationship was best fit by a cubic regression model with inflection (amplification) at fasting glucose at 9.3 mmol/L. Moreover, baseline fasting glucose at 9.3 mmol/L also identified the inflection point at which nonlinear reductions in fasting glucose and 2-h glucose, respectively, were both amplified.

CONCLUSIONS
The respective improvements in β-cell function and glycemia in response to short-term IIT are amplified in those in whom baseline fasting glucose exceeds a defined threshold, consistent with reversal of glucotoxicity.
<b>A Glycemic Threshold above which the Improvement of Beta-cell Function and Glycemia in Response to Insulin Therapy is Amplified in early Type 2 Diabetes:</b><b>The Reversal of Glucotoxicity</b>
Authors: Retnakaran Ravi , Pu Jiajie , Ye Chang , Emery Alexandra , B Harris Stewart , M Reichert Sonja , C Gerstein Hertzel , McInnes Natalia , K Kramer Caroline , Zinman Bernard 
Published: September 2024

<p dir="ltr">OBJECTIVE: Alleviation of unrecognized glucotoxicity, with resultant recovery of beta-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed amongst patients with T2DM. However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve beta-cell function in early T2DM. Thus, for evidence of recovery of glucotoxicity-associated beta-cell dysfunction, we sought to determine whether there exists a baseline fasting glucose threshold above which the post-IIT improvement in both beta-cell function and glycemia is amplified.	</p><p dir="ltr">RESEARCH DESIGN AND METHODS: One-hundred-and-eight adults with T2DM (mean duration 1.8±1.4 years) received 3-weeks of IIT (glargine, lispro). Oral glucose tolerance tests before and after IIT enabled assessment of beta-cell function by Insulin Secretion-Sensitivity Index-2 and insulinogenic index/HOMA-IR. For each level of baseline fasting glycemia from 6.0 to 10.5 mmol/l, we modelled the difference in IIT-induced percentage change in beta-cell function between those at/above the indicated glucose level and those below it.	</p><p dir="ltr">RESULTS: The relationship between baseline fasting glucose and the differential change in beta-cell function was non-linear. Instead, this relationship was best fit by cubic regression model with inflection (amplification) at fasting glucose 9.3 mmol/l. Moreover, baseline fasting glucose 9.3 mmol/l also identified the inflection point at which non-linear reductions in fasting glucose and 2-hour glucose, respectively, were both amplified.	</p><p dir="ltr">CONCLUSION: The respective improvements in beta-cell function and glycemia in response to short-term IIT are amplified in those in whom baseline fasting glucose exceeds a defined threshold, consistent with reversal of glucotoxicity.	</p>
Pengembangan Elektronik Lembar Kerja Peserta Didik (e-LKPD) Pada Mata Pelajaran Informatika Kelas VII SMP
Authors: Ridhoni Rahmi , Zen Zelhendri 
Published: September 2024

The background for conducting the research was due to the lack of teaching materials for Informatics class VII in junior high school. The lack of teaching materials is due to the fact that Informatics is a new subject in the Independent Curriculum. This lack of teaching materials resulted in a lot of student learning outcomes under the KKTP. The research was conducted using Research & Development (R&D) development research with the ADDIE development model. Data collection instruments in this study used validation sheets, student response questionnaires, and pre-test post-test questions. Based on the results of the media validation assessment conducted by experts in the media field I obtained a value of 3.58 which means very valid. From experts in the field of media II, a value of 3.87 is obtained, which means it is very valid. For validation from material experts, a value of 3.80 is obtained, which means it is very valid. Product practicality test results obtained a value of 3.72 which means very practical. The effectiveness test shows tcount>ttable so that there is a significant difference between the pre-test and post-test scores. It can be concluded that this E-LKPD teaching material product is effective and can be used.
Por qué antropólogos y odontólogos deberían trabajar en coordinación para mejorar la salud bucodental (en América Latina)
Authors: Fornai Cinzia 
Published: September 2024

Varios aspectos del sistema craneomandibular deben ser investigados para profundizar nuestra comprensión de las causas próximas y evolutivas de las enfermedades orales más comunes en poblaciones humanas. Las poblaciones de América Central y América del Sur se ven afectadas por una elevada prevalencia de caries y, en general, padecen una salud bucodental deficiente. Por otra parte, tienen un acceso limitado a la atención sanitaria profesional, lo que hace aún más urgente la necesidad de centrar la investigación en estas regiones.
Dada la naturaleza multifactorial de los determinantes que subyacen a las enfermedades bucodentales, y considerando la complejidad del sistema estomatognático, el trabajo interdisciplinar entre antropólogos, odontólogos, especialistas en dolor orofacial, entre otros, parece ser el más adecuado para llevar a cabo investigaciones que aborden las enfermedades bucodentales más comunes y sus posibles efectos funcionales y sociales en el individuo.
Antropólogos y odontólogos comparten un interés común en el sistema craneomandibular, su variación morfológica y sus dolencias, y tradicionalmente han utilizado métodos similares para su investigación. Combinando los diferentes conjuntos de habilidades que poseen, estos profesionales podrían trabajar sinérgicamente para generar conocimientos relevantes que apoyen a las partes interesadas y puedan llegar a los responsables políticos de la atención de la salud bucodental. Su estrecha colaboración ayudaría a identificar los problemas de salud más relevantes, recopilar datos epidemiológicos y comprender sus implicaciones en el bienestar individual, respondiendo así a las necesidades de las poblaciones de estudio y cumpliendo la normativa ética local.
Exploring the Role of Employer Branding in Promoting Diversity Management: A Study on IT Companies in Poland
Authors: Szkudlarek Ewa 
Published: September 2024

Abstract

Objective
The main goal of this research paper is to investigate the role of employer branding in endorsing diversity management among IT companies in Poland.

Methodology
Using a combination of research methods such as a critical review of literature and secondary data analysis, the author investigated the interconnection between employer branding and its influence on policies and practices related to diversity management.

Findings
The research shows a strong link between employer branding and diversity and inclusion management. However, the study found that awareness and engagement level among employees from the Polish IT industry toward diversity management initiatives are relatively low.

Value Added
The research findings provide critical insight into the increasingly essential area of diversity management, underlining the strategic importance of an effective employer brand within the IT industry.

Recommendations
Research results suggest a need for improved communication strategies to help employees understand the importance and benefits of workplace diversity. When correctly implemented, employer branding can promote diversity and inclusion, contributing to the company’s overall success. Future research is suggested to further understand the relationship between employer branding and diversity management in various sectors and countries.