bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deformation twinning induced decomposition of lamellar LPSO structure and its re-precipitation in an Mg-Zn-Y alloy
Authors: Shao X. H. , Zheng S. J. , Chen D. , Jin Q. Q. , Peng Z. Z. , Ma X. L. 
Published: July 2016

AbstractThe high hardness or yield strength of an alloy is known to benefit from the presence of small-scale precipitation, whose hardening effect is extensively applied in various engineering materials. Stability of the precipitates is of critical importance in maintaining the high performance of a material under mechanical loading. The long period stacking ordered (LPSO) structures play an important role in tuning the mechanical properties of an Mg-alloy. Here, we report deformation twinning induces decomposition of lamellar LPSO structures and their re-precipitation in an Mg-Zn-Y alloy. Using atomic resolution scanning transmission electron microscopy (STEM), we directly illustrate that the misfit dislocations at the interface between the lamellar LPSO structure and the deformation twin is corresponding to the decomposition and re-precipitation of LPSO structure, owing to dislocation effects on redistribution of Zn/Y atoms. This finding demonstrates that deformation twinning could destabilize complex precipitates. An occurrence of decomposition and re-precipitation, leading to a variant spatial distribution of the precipitates under plastic loading, may significantly affect the precipitation strengthening.
Coastal Cutthroat Trout Redd Counts Impacted by Natural Water Supply Variations
Authors: Vadas Robert L. , Beecher Hal A. , Boessow Steven N. , Kohr Jonathan H. 
Published: July 2016

Abstract
During 2001–2003, we counted redds of Coastal Cutthroat Trout Oncorhynchus clarkii clarkii and measured microhabitat variables at fresh redds in Irely Creek upstream of Irely Lake in a largely undisturbed watershed within Olympic National Park, Washington. Redd numbers declined abruptly in 2003, the year after a dry summer caused the dewatering of Irely Lake; therefore, we continued the redd counts during 2004–2012 to determine whether pond dewatering was a factor in the decline and whether redd counts would track Irely Lake surface area. The estimated number of redds varied from a high of 51 (in 2002) to a low of 2 (in 2006, 2007, and 2010); increases in estimated redd number occurred after wetter summers, and decreases were observed after drier summers. This pattern was significant in chi-square tests for redd number and the change in redd number with Irely Lake condition in the preceding year (dry, semi-dry, or wet). Rather than indicating juvenile mortality, the lack of a lag in response suggests the mortality of adults that would otherwise have spawned during the subsequent spring. The clear impact of dry summers in one of the wettest regions of North America underscores the important influence of hydrology on fish, even in the absence of other disturbances.
Received September 16, 2015; accepted March 15, 2016 Published online July 20, 2016
A Regional Evaluation of Suwannee Bass and Largemouth Bass Exploitation in North Florida Rivers
Authors: Middaugh Christopher R. , Alfermann Ted , Strickland P. Andrew , Nguyen Phong 
Published: July 2016

Abstract
Suwannee Bass Micropterus notius are a riverine species inhabiting a restricted range within the states of Florida and Georgia. However, little is known about exploitation of Suwannee Bass, which are currently managed in Florida under a single harvest regulation with black basses (genus Micropterus). Regional exploitation of Suwannee Bass in Florida has never been examined in comparison with Largemouth Bass Micropterus salmoides, though such a comparison would allow fisheries managers to assess the efficacy of the current regulation. We estimated regionwide exploitation of both Suwannee Bass and Largemouth Bass in rivers, as facilitated via high-reward ($100), plastic-tipped dart tags. In fall 2013, we tagged 108 legal-sized Suwannee Bass (≥305 mm) across 7 rivers and 160 legal-sized Largemouth Bass across 10 rivers in northern Florida. At the end of 1 year, we found that exploitation rates of Suwannee Bass (0.15) and Largemouth Bass (0.10) in rivers were similar. These estimates were also similar to estimates of Largemouth Bass exploitation in lakes across northern and central Florida.
Received October 30, 2015; accepted March 31, 2016 Published online July 20, 2016
An Assessment of Calcified Structures for Estimating Northern Pike Ages
Authors: Blackwell Brian G. , Kaufman Todd M. , Moos Tyrel S. 
Published: July 2016

Abstract
An important component of effective fisheries management is estimating fish ages. Age estimates can be used to estimate recruitment, relative abundance of age-groups, total mortality, and growth. Because of difficulty in estimating Northern Pike Esox lucius ages using scales and whole cleithra, we compared precision and bias of age estimates from whole cleithra, sectioned cleithra, metapterygoid bones, otoliths, and scales. Metapterygoid bones and sectioned cleithra represent two novel structures for estimating ages in North America, and the assessment of otoliths is limited. Complete agreement and consensus agreement rates were greatest for otoliths, sectioned cleithra, and metapterygoid bones. Otoliths provided the most precise age estimates and whole cleithra were the least precise. Consensus age estimates for sectioned cleithra were lower than whole cleithrum estimates. Consensus age estimates from sectioned otoliths were lower than mean age estimates from scales, sectioned cleithra, and whole cleithra, and y-intercepts from the age-bias plots were significantly different than zero. We suggest that otoliths, sectioned cleithra, and metapterygoid bones can be used to estimate Northern Pike ages, but recommend the use of sectioned otoliths because they had the highest precision and otoliths have become a common means of estimating ages for many species.
Received December 8, 2015; accepted March 31, 2016 Published online July 20, 2016
A method for controlled target strength measurements of pelagic fish, with application to European anchovy (Engraulis encrasicolus)
Authors: Doray Mathieu , Berger Laurent , Le Bouffant Naig , Coail Jean Yves , Vacherot Jean Philippe , de La Bernardie Xavier , Morinière Pierre , Lys Elisabeth , Schwab Romain , Petitgas Pierre 
Published: July 2016

Abstract
Measuring fish target strength (TS) in the wild is challenging because: (i) TS varies versus physical (orientation relative to the incident sound wave, size, and depth) and physiological fish attributes (maturity and condition), (ii) the target species and its aforementioned attributes are difficult to assess in near real time, and (iii) in the case of packed fish schools, accepted echoes may originate from multiple unresolved targets. We propose a method for controlled TS measurements of densely packed small pelagic fish during daytime, based on the joint use of a Remotely Operated Towed Vehicle, “EROC”, with a pelagic trawl fitted with a codend opening system, “ENROL”. EROC, equipped with a 70-kHz split-beam echosounder (Simrad EK60) and a low-light black and white camera, can be moved inside the fishing trawl. Pelagic fish are funnelled into the open trawl and their TS is measured in the middle of the net, where small groups actively swim towards the trawl mouth. The swimming behaviour allows for near-dorsal TS to be measured, minimizing the large effect of incidence angle on TS variability. The EROC camera, located near the open codend, provides optical identification of the species. This method was used to measure the TS of European Anchovy, Engraulis encrasicolus in the Bay of Biscay during 2014. The mean, near dorsal TS was −43.3 dB, for a mean fork length of 12.5 cm. This value is compared to published values of clupeiforms mean TS obtained for a range of natural incidence angles and discussed in the light of TS modelling results obtained for E. encrasicolus.
Single Versus Combined Procedures for Severely Involved Legg-Calvé-Perthes Disease
Authors: Kamegaya Makoto , Morita Mitsuaki , Saisu Takashi , Kakizaki Jun , Oikawa Yasuhiro , Segawa Yuko 
Published: July 2016

Background:
The concept of containment as an effective approach to reduce the risk of femoral head deformity has been questioned because modest results have been achieved after nonoperative and operative treatments for severely involved Legg-Calvé-Perthes disease. Several reports have shown the limited effectiveness of some conventional single procedures. However, there is limited data on the effectiveness of combined procedures.

Methods:
The surgical group comprised 77 patients (mean age 8.3 y) and involved 79 hips. The average follow-up term was 9.5 years. Sixty-five patients were unilaterally involved and 12 patients were bilaterally involved (although 10 of the latter patients only received surgery on 1 hip). Among patients, 28 hips were classified as Herring class B/C border (>8 y old) and 51 hips were Herring class C. The 79 hips were divided into 2 treatment groups for further analysis: group 1, single procedures (femoral varus osteotomy) (n=47); group 2, combined procedures [femoral varus osteotomy+Dega (Pemberton) osteotomy] (n=32).

Results:
Using Stulberg classification I and II (acceptable outcome), the final outcome was statistically significant for group 2 (21 hips, 65.6%) compared with group 1 (18 hips, 38.3%) (P=0.031). The average remodeling efficacy, defined as the change in caput index between preoperation and postoperation, was better in group 2 (12.7%) than in group 1 (3.9%) (P=0.005). The acetabulum-head index and α-angle were also statistically significant in group 2 than in group 1 at the last follow-up. Clinical evaluations were statistically significant in group 2 compared with group 1.

Conclusions:
Both clinically and radiologically, the combined procedure group demonstrated significantly better outcomes with accelerated remodeling in both the severely affected femoral heads and the acetabula compared with the single procedure group. With this procedure, we anticipate the increased likelihood of preventing or delaying coxarthroses in adulthood.

Level of Evidence:
Level III—therapeutic study.
Use of Newly Covered Versus Established Preventive Care Screening: Comparison of Depression and Smoking Screening
Authors: Pfoh Elizabeth R. , Berger Zackary , Mojtabai Ramin , Bailey Jenny , Dy Sydney M. 
Published: July 2016

Abstract:
Pay-for-value initiatives include both depression and smoking screening. Evaluating how patterns of care differ for an established screening (smoking) versus newer screening (depression) can help programs better implement these measures. Our objective is to evaluate (1) patterns of smoking and depression screening and (2) how patient factors affect screening patterns. We analyzed retrospectively collected electronic health record data from 4,763 Medicare-patients in 34 primary care practices between 2010 and 2012. The relationship between multimorbidity, history of stroke, and having depression on receipt of screening was evaluated. The outcome variables were no screening, smoking screening only, or concurrent smoking and depression screening. Fifty percent of patients were screened for smoking at every visit and never screened for depression (n = 2,378). Twelve percent of patients with ≥five visits received both depression and smoking-status screens on each of their first five visits. Screening patterns varied significantly across sites. For example, one site screened approximately 87% of patients for both depression and smoking-status at every visit. Another site screened 93% of patients for smoking during the first visit but did not conduct depression screening. Programs considering initiating new screenings should evaluate the clinic-specific workflow of successful screenings and integrate new screenings using the same strategy.
Applying the New Institute for Healthcare Improvement Inpatient Waste Tool to Identify “Waste” in the Intensive Care Unit
Authors: Almoosa Khalid F. , Luther Katharine , Resar Roger , Patel Bela 
Published: July 2016

Abstract:
Healthcare waste—the inappropriate use of healthcare resources that provides no benefit to patients yet contributes to cost and even harm—is a potentially significant contributor to high healthcare costs. This project aimed to apply a new locally modified Institute for Healthcare Improvement (IHI)–developed waste identification tool to measure the prevalence of and reason for the inappropriate use of intensive care unit (ICU) beds, one type of potential waste. Unnecessary days (i.e., waste) and their causes in a 16-bed “closed” medical ICU (MICU) and a 10-bed “semi-closed” transplant surgical ICU (TSICU) were identified by physicians over a 3-month period. Data on 513 patients admitted to both ICUs for a total of 1,631 patient-days demonstrated that 15% of MICU days and 25.8% of TSICU days were unnecessary. Although causes of waste in each ICU differed, delays in transfer of patients out of the ICU, end-of-life decision-making, and delays in procedures were among the commonest. Determination of waste also varied among physicians, ranging from 4.5% to 27.7% in the MICU and 0%–37.5% in the TSICU. This study found that the IHI waste tool can be effectively used to identify waste in the ICU, which is common and varies based on the ICU type and physician perceptions.
Radiologic Features of World Trade Center–related Sarcoidosis in Exposed NYC Fire Department Rescue Workers
Authors: Girvin Francis , Zeig-Owens Rachel , Gupta Deepti , Schwartz Theresa , Liu Yang , Weiden Michael D. , Prezant David J. , Naidich David P. 
Published: July 2016

Purpose:
An increased incidence of sarcoidosis has been demonstrated in firefighters, supporting the concern that occupational/environmental exposure may pose an etiologic risk factor. This incidence increased further after September 11, 2001 following exposure to World Trade Center (WTC) dust and gases. We review computed tomography (CT) features in this population, comparing the range of findings and physiological correlates with those typically reported in unexposed individuals with pulmonary sarcoidosis.

Materials and Methods:
With CT imaging we retrospectively identified 46 patients with WTC-related sarcoidosis, between March 18, 2002 and April 5, 2014. Scans were independently reviewed by 2 dedicated thoracic radiologists and assessed for disease patterns and correlation with pulmonary functions.

Results:
The majority (37/46; 80%) had symmetric mediastinal and hilar lymphadenopathy. Similarly, most (38/46; 83%) had perilymphatic nodules. Foci of ill-defined ground glass attenuation were present in 6 (13%). Coalescent nodularity was present in 15 (33%). Only 3 (7%) had parenchymal reticulation. A mixed pattern of lung findings was present in 21 (46%). When all forms of parenchymal disease were scored by zonal distribution, 21 (46%) had parenchymal disease predominantly involving mid and upper lungs; 11/46 (24%) had a random distribution without zonal predominance; 6/46 (13%) demonstrated atypical lower zone predominance. Whereas 15/46 (33%) had obstructive airways disease on pulmonary function tests, there were no CT findings that were predictive of obstructive airways disease.

Conclusions:
The majority of cases of WTC-related sarcoidosis demonstrated typical radiographic appearances of sarcoidosis, with symmetric hilar and mediastinal lymphadenopathy and mid to upper lung perilymphatic nodules; these findings were consistent with other previously reported cases of sarcoid-like granulomatous disease in association with various alternate underlying etiologies. There was no correlation between disease patterns or extent on CT and pulmonary function testing, likely at least in part due to the overall mild extent of disease in this population.
Comparing the Effectiveness and Safety of the Addition of and Switching to Aripiprazole for Resolving Antipsychotic-Induced Hyperprolactinemia: A Multicenter, Open-Label, Prospective Study
Authors: Yoon Hui Woo , Lee Jung Suk , Park Sang Jin , Lee Seon-Koo , Choi Won-Jung , Kim Tae Yong , Hong Chang Hyung , Seok Jeong-Ho , Park Il-Ho , Son Sang Joon , Roh Daeyoung , Kim Bo-Ra , Lee Byung Ook 
Published: July 2016

Objectives
Hyperprolactinemia is an important but often overlooked adverse effect of antipsychotics. Several studies have shown that switching to or adding aripiprazole normalizes antipsychotic-induced hyperprolactinemia. However, no study has directly compared the effectiveness and safety of the 2 strategies.

Methods
A total of 52 patients with antipsychotic-induced hyperprolactinemia were recruited. Aripiprazole was administered to patients with mild hyperprolactinemia (serum prolactin level < 50 ng/mL). Patients with severe hyperprolactinemia (serum prolactin level > 50 ng/mL) were randomized to an aripiprazole-addition group (adding aripiprazole to previous antipsychotics) or a switching group (switching previous antipsychotics to aripiprazole). Serum prolactin level, menstrual disturbances, sexual dysfunction, psychopathologies, and quality of life were measured at weeks 0, 1, 2, 4, 6, and 8.

Results
Both the addition and switching groups showed significantly reduced serum prolactin level and menstrual disturbances and improved sexual dysfunction. In patients with severe hyperprolactinemia, the numbers of patients with hyperprolactinemia and menstrual disturbance in the switching group were significantly lower than those in the addition group at week 8.

Conclusions
Both the addition and switching strategies were effective in resolving antipsychotic-induced hyperprolactinemia and hyperprolactinemia-related adverse events, including menstrual disturbances and sexual dysfunction. In addition, these findings suggest that switching to aripiprazole may be more effective than addition of aripiprazole for normalizing hyperprolactinemia and improving hyperprolactinemia-related adverse events in patients with schizophrenia.
Whose sample is it anyway? Widespread misannotation of samples in transcriptomics studies
Authors: Toker Lilah , Feng Min , Pavlidis Paul 
Published: July 2016

AbstractConcern about the reproducibility and reliability of biomedical research has been rising. An understudied issue is the prevalence of sample mislabeling, one impact of which would be invalid comparisons. We studied this issue in a corpus of human genomics studies by comparing the provided annotations of sex to the expression levels of sex-specific genes. We identified apparent mislabeled samples in 46% of the datasets studied, yielding a 99% confidence lower-bound estimate for all studies of 33%. In a separate analysis of a set of datasets concerning a single cohort of subjects, 2/4 had mislabelled samples, indicating laboratory mix-ups rather than data recording errors. While the number of mixed-up samples per study was generally small, because our method can only identify a subset of potential mix-ups, our estimate is conservative for the breadth of the problem. Our findings emphasize the need for more stringent sample tracking, and that re-users of published data must be alert to the possibility of annotation and labelling errors.
Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy
Authors: Byars Sean G. , Huang Qin Qin , Gray Lesley-Ann , Ripatti Samuli , Abraham Gad , Stearns Stephen C. , Inouye Michael 
Published: July 2016

AbstractTraditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals underlying coronary artery disease (CAD) in worldwide populations, using novel approaches to quantify relationships between polygenic selection signals and CAD genetic risk. We identified new candidate adaptive loci that appear to have been directly modified by disease pressures given their significant associations with CAD genetic risk. These candidates were all uniquely and consistently associated with many different male and female reproductive traits suggesting selection may have also targeted these because of their direct effects on fitness. This suggests the presence of widespread antagonistic-pleiotropic tradeoffs on CAD loci, which provides a novel explanation for the maintenance and high prevalence of CAD in modern humans. Lastly, we found that positive selection more often targeted CAD gene regulatory variants using HapMap3 lymphoblastoid cell lines, which further highlights the unique biological significance of candidate adaptive loci underlying CAD. Our study provides a novel approach for detecting selection on polygenic traits and evidence that modern human genomes have evolved in response to CAD-induced selection pressures and other early-life traits sharing pleiotropic links with CAD.Author SummaryHow genetic variation contributes to disease is complex, especially for those such as coronary artery disease (CAD) that develop over the lifetime of individuals. One of the fundamental questions about CAD — whose progression begins in young adults with arterial plaque accumulation leading to life-threatening outcomes later in life — is why natural selection has not removed or reduced this costly disease. It is the leading cause of death worldwide and has been present in human populations for thousands of years, implying considerable pressures that natural selection should have operated on. Our study provides new evidence that genes underlying CAD have recently been modified by natural selection and that these same genes uniquely and extensively contribute to human reproduction, which suggests that natural selection may have maintained genetic variation contributing to CAD because of its beneficial effects on fitness. This study provides novel evidence that CAD has been maintained in modern humans as a byproduct of the fitness advantages those genes provide early in human lifecycles.
Beyond APs and VPs: evidences of chaos and self-organized criticality in electrical signals in plants
Authors: Saraiva G. F. R. , Ferreira A. S. , Souza G. M. 
Published: July 2016

AbstractStudies on plant electrophysiology are mostly focused on specific traits of action potentials (APs) and/or variation potentials (VPs), often in single cells. Inspired by the complexity of the signaling network in plants and by analogies with some traits of neurons in human brains, we have sought for evidences of high complexity in the electrical dynamics of plant signaling, beyond APs and VPs responses. Thus, from EEG-like data analyses of soybean plants, we showed consistent evidences of chaotic dynamics in the electrical time series. Furthermore, we have found that the dynamic complexity of electrical signals is affected by the plant physiological conditions, decreasing when plant was stressed. Surprisingly, but not unlikely, we have observed that, after stimuli, electrical spikes arise following a power law distribution, which is indicative of self-organized criticality (SOC). Since, as far as we know, these were the first evidences of chaos and SOC in plant electrophysiology, we have asked follow-up questions and we have proposed new hypotheses, seeking for improving our understanding about these findings.