bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Key Competencies of Health Professionals in the Assessment and Care of Adults at Risk of Suicide Through Education and Technology
Authors: Ryan Kathryn , Tindall Claudia , Strudwick Gillian 
Published: August 2017

Purpose:
This article describes efforts undertaken to improve the clinical competencies of health professionals in the area of suicide risk assessment, documentation, and care planning.

Description of the Project:
Best practices that fit the mental health and addictions setting were identified from the Registered Nurses’ Association of Ontario Best Practice Guideline on Assessment and Care of Adults at Risk for Suicidal Ideation and Behaviour. A variety of methods were used to implement the guidelines at the Centre for Addiction and Mental Health in Toronto, Ontario, Canada. These included 3 in-person educational modules, an e-learning module, and the creation of an electronic health record suicide risk assessment documentation form.

Outcome:
Results showed that interprofessional team members improved their suicide awareness and increased their confidence and knowledge in suicide risk assessment and the identification of interventions for clients at risk. Organizational level performance and quality improvement activities after implementation of the education and the electronic suicide risk assessment documentation form are being implemented through a collaboration between performance improvement, clinical education and informatics, and professional practice.

Conclusion:
The success of an interprofessional educational program of this nature is dependent on the collaboration of a number of stakeholders from a variety of areas of the organization.
Acellular Dermal Matrix in Immediate Expander/Implant Breast Reconstruction: A Multicenter Assessment of Risks and Benefits
Authors: Sorkin Michael , Qi Ji , Kim Hyungjin M. , Hamill Jennifer B. , Kozlow Jeffrey H. , Pusic Andrea L. , Wilkins Edwin G. 
Published: August 2017

Background:
Acellular dermal matrix has gained widespread acceptance in immediate expander/implant reconstruction because of perceived benefits, including improved expansion dynamics and superior aesthetic results. Although previous investigators have evaluated its risks, few studies have assessed the impact of acellular dermal matrix on other outcomes, including patient-reported measures.

Methods:
The Mastectomy Reconstruction Outcomes Consortium Study used a prospective cohort design to evaluate patients undergoing postmastectomy reconstruction from 10 centers and 58 participating surgeons between 2012 and 2015. The analysis focused on women undergoing immediate tissue expander reconstruction following mastectomies for cancer treatment or prophylaxis. Medical records and patient-reported outcome data, using the BREAST-Q and Numeric Pain Rating Scale instruments, were reviewed. Bivariate analyses and mixed-effects regression models were applied.

Results:
A total of 1297 patients were evaluated, including 655 (50.5 percent) with acellular dermal matrix and 642 (49.5 percent) without acellular dermal matrix. Controlling for demographic and clinical covariates, no significant differences were seen between acellular dermal matrix and non–acellular dermal matrix cohorts in overall complications (OR, 1.21; p = 0.263), major complications (OR, 1.43; p = 0.052), wound infections (OR, 1.49; p = 0.118), or reconstructive failures (OR, 1.55; p = 0.089) at 2 years after reconstruction. There were also no significant differences between the cohorts in the time to expander/implant exchange (p = 0.78). No significant differences were observed in patient-reported outcome scores, including satisfaction with breasts, psychosocial well-being, sexual well-being, physical well-being, and postoperative pain.

Conclusions:
In this multicenter, prospective analysis, the authors found no significant acellular dermal matrix effects on complications, time to exchange, or patient-reported outcome in immediate expander/implant breast reconstruction. Further studies are needed to develop criteria for more selective use of acellular dermal matrix in these patients.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, II.
Subependymal Heterotopia Mimicking Mass in Conventional Magnetic Resonance Imaging: Demonstration With 3T Advanced Neuroimages
Authors: Aktas Filiz , Ogul Hayri 
Published: August 2017

Abstract
The authors reported a rare patient with large subependymal heterotopia mimicking cerebral neoplasia. A 22-year-old female was admitted with a history of right-sided paresthesia accompanied by progressive headache. Cerebral magnetic resonance (MR) imaging showed a large solid lesion in the left frontal lobe. Advanced MR images proved that the lesion was compatible with subependymal heterotopia. Large subependymal heterotopia may mimick cerebral neoplasia.
Classification of the Residual Cranial Defects and Selection of Reconstruction Materials
Authors: Sahoo Nanda Kishore , N Mohan Rangan , Tomar Kapil , Bhat Sudarshan 
Published: August 2017

Abstract
The cranial defects are complex in nature and are due to various causes. Therefore, there is a need for a common term of reference to these defects. This requirement stood as a prime reason for proposing a classification system for cranial defects. The classification is based on 2 decades of experience in cranioplasty. This efficient and simple way of representation would fill the existing lacunae for a systematic communication on cranial defects. Over the ages the evolution of reconstruction and grafting had undergone a massive progress. Therefore, it is essential to enumerate all available graft and bio-materials for restoring the cranial defects. The aetiology for these defects, age and sex of the patient, site and size of the defect, associated systemic conditions, cost factor, and operator's choice are the factors that play key role in the selection of the reconstructive material. This article discusses on these factors in cranioplasty. High success rate with excellent function and cosmetic outcome in using a variety of materials, as shared in this article. The advantages of autografts cannot be matched by any existing alloplast. However, in case of larger defects, for a better cosmetic outcome and to reduce the donor site morbidity, alloplasts are the most widely preferred material of choice.
Environmental deformations dynamically shift the grid cell spatial metric
Authors: Keinath Alexandra T , Epstein Russell A , Balasubramanian Vijay 
Published: August 2017

AbstractEnvironmental deformations induce stereotyped distortions in the time-averaged activity of grid and place cells. We hypothesized that these effects are partly driven by border cell inputs which reset the spatial phase of grid cells, maintaining learned relationships between grid phase and environmental boundaries without altering inherent grid scale. A computational model of this mechanism reproduced diverse distortions during deformations, including scale-dependent and local distortions of grid fields, and stretched, duplicated, and fractured place fields. This model predicted a striking new effect: dynamic, history-dependent, boundary-tethered ‘shifts’ in grid phase during deformations. We reanalyzed two rodent grid cell rescaling datasets and found direct evidence of these shifts, which have not been previously reported and contribute to the appearance of rescaling. These results demonstrate that the grid representation of geometrically deformed environments is not fixed, but rather dynamically changes with the specific experience of the navigator.
DNA-PK facilitates HIV transcription by regulating the activity of RNA polymerase II and the recruitment of transcription machinery at HIV LTR
Authors: Zicari Sonia , Sahu Geetaram , Dubrovsky Larisa , Sun Lin , Yue Han , Jada Tejaswi , Ochem Alex , Bukrinsky Michael , Simon Gary , Tyagi Mudit 
Published: August 2017

ABSTRACTDespite the use of highly effective antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents cure and eradication of HIV infection. These transcriptionally silent proviruses are well protected from both the immune system and HAART regimens. Thus, in order to tackle the problem of latent HIV reservoirs, it is a prerequisite to define all the pathways that regulate HIV transcription. We have previously reported that DNA-PK facilitates HIV transcription by interacting with the RNA polymerase II (RNAP II) complex recruited at HIV LTR. To extend those studies further, here we demonstrate that DNA-PK promotes HIV transcription by supporting it at several stages, including initiation, pause-release and elongation. We discovered that DNA-PK increases phosphorylation of RNAP II C-terminal domain (CTD) at serine 5 (Ser5) and serine 2 (Ser2) by both directly catalyzing and by augmenting the recruitment of P-TEFb at HIV LTR. We found that DNA-PK facilitates the establishment of euchromatin structure at HIV LTR, which further supports HIV gene expression. DNA-PK inhibition or knockdown leads to the severe impairment of HIV gene expression and conversion of euchromatin to heterochromatin at HIV LTR. It also profoundly restricts HIV replication and reactivation of latent provirus. DNA-PK promotes the recruitment of TRIM28 at LTR and facilitates the release of paused RNAP II through TRIM28 phosphorylation. The results were reproduced in cell lines belonging to both lymphoid and myeloid lineages and were confirmed in primary CD4+T cells and peripheral blood mononuclear cells (PBMCs) from HIV-infected patients.IMPORTANCE:Our results reveal the important role of DNA-PK in supporting HIV transcription, replication and latent proviral reactivation. Intriguingly, this study sheds light on an important pathway that affects HIV gene expression. These findings provide strong rationale for developing and using transcriptional inhibitors, such as DNA-PK inhibitors, as supplement to HAART regimens in order to further enhance their effectiveness and to suppress toxicity due to HIV proteins.
Accelerated human liver progenitor generation from pluripotent stem cells by inhibiting formation of unwanted lineages
Authors: Ang Lay Teng , Tan Antson Kiat Yee , Autio Matias Ilmari , Goh Joanne Su-Hua , Choo Siew Hua , Lee Kian Leong , Tan Jianmin , Pan Bangfen , Hui Lee Jane Jia , Xin Yeo Isabelle Kai , Yee Wong Chloe Jin , Lum Jen Jen , Loh Chet Hong , Lim Ying Yan , Li Oh Jueween Ling , Lynn Chia Cheryl Pei , Chen Angela , Chen Qing Feng , Weissman Irving L. , Loh Kyle M. , Lim Bing 
Published: August 2017

AbstractDespite decisive progress in differentiating pluripotent stem cells (PSCs) into diverse cell-types, the often-lengthy differentiation and functional immaturity of such cell-types remain pertinent issues. Here we address the first challenge of prolonged differentiation in the generation of hepatocyte-like cells from PSCs. We delineate a roadmap describing the extracellular signals controlling six sequential branching lineage choices leading from pluripotency to endoderm, foregut, and finally, liver progenitors. By blocking formation of unwanted cell-types at each lineage juncture and manipulating temporally-dynamic signals, we accelerated generation of 89.0±3.1% AFP+human liver bud progenitors and 87.3±9.4% ALBUMIN+hepatocyte-like cells by days 6 and 18 of PSC differentiation, respectively. 81.5±3.2% of hepatocyte-like cells expressed metabolic enzyme FAH (as assayed by a new knock-in reporter line) and improved short-term survival in theFah-/-Rag2-/-Il2rg-/-mouse model of liver failure. Collectively the timed signaling interventions indicated by this developmental roadmap enable accelerated production of human liver progenitors from PSCs.
Salad cream formulated with tofu and coconut oil
Authors: Sirison Jiraporn , Rirermwong Awika , Tanwisuit Nattawadee , Meaksan Taviyaporn 
Published: August 2017

Purpose
The purpose of this paper is to develop a new salad cream formulation from a mixture of tofu and coconut oil for replacement of egg yolk and soy oil, respectively.

Design/methodology/approach
A salad cream formulation mainly composing of edible oil, egg and vinegar was formulated. Ratios of egg yolk and soy oil were replaced by tofu and coconut oil, respectively. The formulated salad creams were determined for pH, color, viscosity, protein and fat. Sensory acceptances of formulated products was evaluated by using a seven-point hedonic scale test and untrained panelists (n=30). The formulated salad creams were stored in a refrigerator for 14 days and determined for pH, color and viscosity.

Findings
The results showed that the formulated salad creams using the mixture of 50 percent tofu and 50 percent egg yolk (RE) by weight of egg yolk ratio in control presented 4.25+0.01 of pH which was comparable to control. The highest scores in the sensory test were obtained in the formula using 37 percent coconut oil by weight of salad cream. The formulated salad creams using tofu and coconut oil (REC) presented 4.42+0.03 of pH, 4.25+0.05 cm. of viscosity, and 87.36+0.44 (L), −1.13+0.04 (a), 16.32+0.22 (b) of color values. Protein and fat contents were 4.79 and 27.59 percent (w/w) in the REC, respectively. After storage under refrigerated, pH, color and viscosity of the modified product were less changed.

Originality/value
Replacement of egg yolk and soy oil with tofu and coconut oil in salad creams was feasible. The REC was less changed in its quality both fresh and after storage. It was accepted in sensory evaluation. The REC could prepare at home and being a food choice for consumers.
The use of electronic resources by undergraduate students at the University of Venda, South Africa
Authors: Tlakula Tintswalo Pascalis , Fombad Madeleine 
Published: August 2017

Purpose
This paper aims to establish the level of use of the electronic resources at the University of Venda, which is one of the previously disadvantaged universities in South Africa. It identifies the different electronic resources used at the university, determines the level of awareness and training in the use of these resources and suggests ways in which electronic resources may be enhanced. The rapid changes in the information and communication technology (ICTs) have influenced service delivery in academic libraries in terms of how information is gathered, accessed, retrieved and used. Hence, electronic resources are invaluable research tools in academic libraries in the twenty-first century.

Design/methodology/approach
A qualitative research methodology was adopted, and semi-structured interviews were conducted with each participant to get in-depth information. The target population was all third-year students registered with the School of Human and Social Sciences at the University of Venda. The third year undergraduate students from this particular school where chosen because statistics revealed that these students where ranked among the top in the use of computers.

Findings
The findings revealed that the level of usage of these resources by undergraduate students is elementary and limited to SABINET and EBSCO host. Undergraduate student’s level of awareness of the different electronic resources is low. They confused electronic resources to Web-based internet sources. It also revealed that the level of awareness and training in the use of these resources is still generic, as training is mostly a once off orientation at the first year.

Research limitations/implications
This paper focuses on third year undergraduate students who were using computers because the researchers were interested in finding out whether students using computers were also using electronic resources. It excluded other profiles such as age, gender and computer usage behaviour of electronic resources.

Practical implications
Adequate use and knowledge of electronic resources at universities is instrumental towards realisation of the country’s ICT Strategy and the outcome-based education (OBE) model of teaching movement. Suggestions are made to the university, the university library, university librarians and the Library Association of South Africa on how to enhance the use of electronic resources.

Originality/value
It establishes the level of use of electronic resources in one of South African historically disadvantaged universities, a point of contact to other previously South African disadvantaged universities and make suggestions on how electronic resources may be enhanced. It adds to the body of knowledge on the use of electronic resources in academic libraries in South African universities.
Older LGB&T housing in the UK: challenges and solutions
Authors: Wathern Tina , Green Robert William 
Published: August 2017

Purpose
This paper considers the challenges and solutions in relation to older lesbian, gay, bisexual and trans (LGB&T) housing in the UK. The purpose of this paper is to identify the key housing issues and concerns affecting older LGB&T people in the UK, and ways in which these might be addressed.

Design/methodology/approach
This is a practical discussion which focusses on the issues of policies and provision in relation to older LGB&T housing in the UK, both specialist and mainstream housing.

Findings
There is a growing body of literature from both the voluntary sector and academic researchers highlighting the housing issues affecting older LGB&T people. There is a need for both specialist and appropriate mainstream housing provision. However, policy and funding issues constrain the creation and/or development of such provision.

Practical implications
Policy makers and housing providers in the UK need to address, and meet, the diverse housing needs of older LGB&T people.

Social implications
Until their housing needs are met, many older LGB&T people remain concerned about their housing futures, and may end up living in housing which is not their preference and which is not suitable for them.

Originality/value
This paper is the first to provide a comprehensive overview of the work of Stonewall Housing’s network for older LGB&T people, and the challenges and solutions which have been identified in relation to their housing issues and concerns.
Quality control of constructions: European trends and developments
Authors: Meijer Frits , Visscher Henk 
Published: August 2017

Purpose
This paper aims to evaluate the quality control systems for constructions in seven countries in Europe with the purpose to trace innovative approaches and best practices that can serve as examples for other countries.

Design/methodology/approach
The paper is based on a series of research projects carried out over a number of years. The research results were updated in 2016 with a desktop research project in seven European countries. The results from this latest project form the heart of this paper. The information is organised into tables that describe and analyse the main features of the quality control systems of the countries (e.g. scope, focus and main characteristics of the procedures and quality demands on building professionals).

Findings
Several similar trends can be recognised in the quality control systems of the various European Union (EU) countries. Quality control is getting more and more privatised and the control framework is setting checks and balances throughout the construction process. Other findings are that scope and focus of the statutory control is unbalanced. Within the control processes emphasis is put on the safety aspects of complex constructions. Far fewer demands are made on the quality of the builders. Re-orientation of the building regulatory framework seems to be needed.

Research limitations/implications
The paper only focusses on European countries where private quality control is established and on selected topics. The findings are based on desktop research and not on the practical experiences of the stakeholders involved in the countries studied.

Practical implications
The paper draws some important recommendations for policymakers in the building regulatory field. It suggests both an enhancement of the effectiveness of the quality control procedure as well as the commitment of builders to comply with the regulations.

Social implications
The quality of constructions is essential for the wellbeing and safety of its users, its occupants or its visitors. This applies to the whole range of quality aspects: structural- and fire safety, health, sustainability and usability aspects. The analyses and recommendations of this paper aim to contribute to an improvement of the overall construction quality.

Originality/value
The paper makes an original contribution to the (limited) literature that is available in this field. The results can be used to situate the quality control systems of each member state within the EU, to assess the main trends, and it can be used as a guide to develop strategic choices on possible improvements in each country.
Attitudes toward crowdsourced, community-involved new product development
Authors: Wu Juanjuan , Kim Angella J. , Chen Lili , Johnson Kim K.P. 
Published: August 2017

PurposeIn the context of crowdsourced new product development (NPD), the purpose of this paper is to investigate the optimal level of community involvement (CI) (e.g. zero, limited, and high) when creating products from the perspectives of both ordinary and advanced users. The authors also investigate the influence of design interest and need for social affiliation on users’ attitudes toward and willingness to use community co-design.Design/methodology/approachThe authors conducted two survey studies using ordinary (Study 1,n=199) and advanced users (Study 2,n=131) to evaluate the co-designed T-shirts reflecting varying levels of CI (i.e. zero, limited, and high). The stimuli for both studies were the same and included ten sets of T-shirt co-designs generated from a CI crowdsourced website, Threadless. Fishbein’s (1963) multi-attribute attitude model was used to compute subjects’ overall attitude score toward the T-shirt co-designs.FindingsResults showed both ordinary and advanced user groups rated the design quality of products reflecting limited CI lower than those of zero CI. Advanced users also rated the design quality and sales potential of products from limited CI lower than those of high CI. Further, advanced users indicated that products resulting from high CI reflected significantly better designs with regard to color, shape/line, size, general theme, and overall design as compared to products from limited CI. Design interest as well as need for social affiliation influenced users’ willingness to use community co-design and their attitudes toward a community co-design experience.Originality/valueThe research made an important differentiation between zero, limited, and high CI during the co-design process as well as between ordinary users and advanced users contributed to the extant literature addressing crowdsourcing in NPD.