bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating extracellular vesicles as novel biomarkers for pulmonary arterial hypertension in patients with systemic lupus erythematosus
Authors: Ding Zhe , Qi Fumin , Liu Li , Wang Zhouming , Zhang Na , Lyu Xing , Sun Wenwen , Du Jun , Song Haoming , Hou Hou , Guo Ying , Wang Xiaomei , Liu Ming-Lin , Wei Wei 
Published: September 2024

IntroductionPulmonary arterial hypertension (PAH) is a serious complication of systemic lupus erythematosus (SLE) with increased mortality. A prothrombotic state may contribute to pathogenesis of SLE-PAH. Extracellular vesicles (EVs) are known to be associated with thrombosis. Here, we investigated circulating EVs and their associations with SLE-PAH.MethodsEighteen SLE-PAH patients, 36 SLE-non-PAH patients, and 36 healthy controls (HCs) were enrolled. Flow cytometry was used to analyze circulating EVs from leukocytes (LEVs), red blood cells (REVs), platelets (PEVs), endothelial cells (EEVs), and Annexin V+ EVs with membrane phosphatidylserine (PS) exposure.ResultsPlasma levels of all EV subgroups were elevated in SLE patients with or without PAH compared to HCs. Furthermore, plasma Annexin V+ EVs, LEVs, PEVs, REVs, EEVs, and Annexin V+ REVs were significantly elevated in SLE-PAH patients compared to SLE-non-PAH patients. Additionally, PAH patients with moderate/high SLE showed a significant increase in LEVs, PEVs, REVs, Annexin V+ EVs, and Annexin V+ REVs compared to SLE-non-PAH patients. However, PAH patients with inactive/mild SLE only exhibited elevations in Annexin V+ EVs, REVs, and Annexin V+ REVs. In the SLE-PAH patients, EEVs were positively correlated with pulmonary arterial systolic pressure, while PEVs and EEVs were positively correlated with right ventricular diameter. Moreover, the receiver operating characteristic curve indicated that Annexin V+ EVs, LEVs, PEVs, REVs, EEVs and Annexin V+ REVs could predict the presence of PAH in SLE patients. Importantly, multivariate logistic regression analysis showed that circulating levels of LEVs or REVs, anti-nRNP antibody, and serositis were independent risk factors for PAH in SLE patients.DiscussionFindings reveal that specific subgroups of circulating EVs contribute to the hypercoagulation state and the severity of SLE-PAH. Higher plasma levels of LEVs or REVs may serve as biomarkers for SLE-PAH.
The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study
Authors: Ozkan Hasan , Duman Nuray , Tuzun Funda , Narter Fatma , Akyildiz Can , Altuncu Emel , Satar Mehmet , Ozdemir Mustafa , Kurt Abdullah , Tugcu Ali U. , Konak Murat , Uygun Saime Sundus , Yilmaz Semerci Seda , Dikmen Rahime T. , Baysal Bora , Zeybek Cemile K. , Kostekci Yasemin Ezgi , Sahin Suzan , Tutal Merve , Anik Ayse , Buyuktiryaki Mehmet , Karagol Belma S. , Tunç Gaffari , Colak Derya , Cetin Hasan , Orman Aysen , Olukman Ozgur , Deveci Mehmet Fatih , Sarici Dilek , Cakir Salih C. , Keskinoglu Pembe 
Published: September 2024

ObjectiveThe objective of this study was to evaluate the efficacy and safety of isotonic and hypotonic intravenous fluids in maintenance fluid therapy for term infants.MethodsThis was a multi-centre, prospective, observational study conducted in 21 participating centres from December 30, 2020, to June 30, 2023. The study included term newborns requiring parenteral fluid therapy for maintenance (NCT04781361). The fluid treatment was divided into two groups based on the concentration of sodium in the parenteral fluid, designated as hypotonic (NaCl &lt;130 mmol/L) and isotonic (NaCl = 130–154 mmol/L). The primary outcomes were the change in mean plasma sodium (pNa) levels per hour (∆pNa mmol/L/h), the incidence of hyponatremia (pNa &lt;135 mmol/L) and hypernatremia (pNa &gt;145 mmol/L), and the occurrence of clinically significant changes in sodium levels (∆pNa &gt;0.5 mmol/L/h).ResultsA total of 420 patients from 21 centers were included. The ∆pNa was negative in the hypotonic fluid group and positive in the isotonic fluid group, with a significant difference between the groups [respectively −0.07 ± 0.03 (95% CI: −0.13 to −0.02); 0.04 ± 0.03 (95%CI: −0.02 to 0.09), p = 0.04]. There was no difference between the groups in terms of the development of hypernatremia or a clinically meaningful pNa increase. The hypotonic fluid group had a higher incidence of hyponatremia and a clinically meaningful sodium decrease compared to the isotonic fluid group [7.9% vs. 1.2% (OR:6.5, p:0.03)] and [12.2% vs.4.2% (OR:2.9, p = 0.03)].ConclusionContrary to current understanding, this large-scale study is the first to demonstrate that the use of hypotonic fluids in maintenance fluid therapy for newborns poses a risk of hyponatremia development, whereas isotonic fluid therapy appears safe.
Preoperative prediction of lymph node metastasis in endometrial cancer patients via an intratumoral and peritumoral multiparameter MRI radiomics nomogram
Authors: Yan Bin , Zhao Tingting , Deng Ying , Zhang Yili 
Published: September 2024

IntroductionWhile lymph node metastasis (LNM) plays a critical role in determining treatment options for endometrial cancer (EC) patients, the existing preoperative methods for evaluating the lymph node state are not always satisfactory. This study aimed to develop and validate a nomogram based on intra- and peritumoral radiomics features and multiparameter magnetic resonance imaging (MRI) features to preoperatively predict LNM in EC patients.MethodsThree hundred and seventy-four women with histologically confirmed EC were divided into training (n = 220), test (n = 94), and independent validation (n = 60) cohorts. Radiomic features were extracted from intra- and peritumoral regions via axial T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) mapping. A radiomics model (annotated as the Radscore) was established using the selected features from different regions. The clinical parameters were statistically analyzed. A nomogram was developed by combining the Radscore and the most predictive clinical parameters. Decision curve analysis (DCA) and the net reclassification index (NRI) were used to assess the clinical benefit of using the nomogram.ResultsNine radiomics features were ultimately selected from the intra- and peritumoral regions via ADC mapping and T2WI. The nomogram combining the Radscore, serum CA125 level, and tumor area ratio achieved the highest AUCs in the training, test and independent validation sets (nomogram vs. Radscore vs. clinical model: 0.878 vs. 0.850 vs. 0.674 (training), 0.877 vs. 0.838 vs. 0.668 (test), and 0.864 vs. 0.836 vs. 0.618 (independent validation)). The DCA and NRI results revealed the nomogram had greater diagnostic performance and net clinical benefits than the Radscore alone.ConclusionThe combined intra- and peritumoral region multiparameter MRI radiomics nomogram showed good diagnostic performance and could be used to preoperatively predict LNM in patients with EC.
Physical activity and sedentary behavior among ambulatory children with cerebral palsy using accelerometer: a cross-sectional study
Authors: Alamoudi Njoud Aydhah , Algabbani Maha F. , Al-Heizan Muhammad O. , Alhusaini Adel A. 
Published: September 2024

Background and objectivePhysical activity (PA) is paramount for childhood development and growth. However, children diagnosed with Cerebral Palsy (CP) were often considered sedentary, and their physical inactivity was associated with adverse health conditions and complications. Therefore, this study aimed to objectively describe and compare the PA levels and SB levels of children with and without CP of the same age group. It also studied the factors correlating with PA, SB, and step count per day in children with CP.Subjects and methodsA cross-sectional study using a wrist-worn accelerometer was conducted. PA and SB were measured over seven consecutive days.ResultsEighty-five children aged 6–12 years, consisting of 41 children with CP and 44 TD children, participated in this study with a mean age of 9.18 ± 1.95 and 8.45 ± 1.78 years, respectively. According to the gross functional measures, 53.6% of children with CP were classified as first classification. A significant amount of time was spent in SB and Light PA (LPA) by children with CP compared to TD children, and no significant differences were observed in moderate PA (MPA) or step count. Gender mainly affected MPA as girls spent more time in MPA than boys. The age, height, and weight of children with CP correlate significantly with SB. As children's age, height, and weight increase, SB increases. Additionally, children with higher weights have lower step counts per day.ConclusionThis study showed that children with CP spend more time in LPA and SB than typically developed children. Therefore, concerted efforts are needed to encourage physical activity and reduce the sedentary lifestyle, to take into account the gender and anthropometric measures of children to enhance the quality of life among children with CP, and to consider gender and anthropometric measures of the children.
أفكار ابـن وهب في كتابه (البرهان في وجـوه البيان): قـراءة مـن المنظـور التداولـي
Authors: جمعة يوسف إبراهيم خلف 
Published: September 2024

يتغيا هذا البحث الكشف عن كُنه الأفكار الواردة في كتاب «البرهان في وجوه البيان» لابن وهب، وذلك من خلال قراءته قراءة فاحصة، ويرصد البحث علة عدم اقتصار المؤلف على التنظير لبلاغة الجنسين الأدبيين: الشعر والنثر. ولجنوح المؤلف إلى رصد بلاغة زوايا اجتماعية كالأحاديث والمناظرة؛ اتجه البحث إلى الدراسات الاجتماعية التداولية، ونحا في ضوء ذلك منحيين، اختص الأول منهما بجانب رصد المفاهيم الشائعة حول البلاغة وتمييزها عن الحد الذي تخيّره المؤلف، وارتكز الثاني على الجانب الذي يظهر فيه الاعتداد بالجوانب الاجتماعية التداولية؛ ليقدم أفكار ابن وهب بصورة تسهم في إعادة النظر بأهميتها.
ВЛИЯНИЕ СОВРЕМЕННОЙ ЦИФРОВОЙ ЭРЫ НА РАЗВИТИЕ ГУМАНИТАРНЫХ НАУК
Authors: Карыбекова Н.М. 
Published: September 2024

Макалада «педагогикалык колдоо» жана «жеңилдетүү» түшүнүктөрү аныкталды, куруунун кеңири, тар, локалдык, бирдиктүү мааниде аныкталат. Азыркы педагогикалык методологиянын идеяларын ишке ашыруу структурасында кеңири, жергиликтүү, тар, бирдиктүү маанилер жөнүндөгү түшүнүктөр такталган. Документте студенттин инсандыгын өнүктүрүү маселелерин персонификацияланган детерминисттик жана талап кылынган педагогикалык колдоонун каражаттары жана методдору аркылуу чечүүнүн сапатын оптималдаштыруунун педагогикалык шарттарынын концепциясы жана мазмуну берилген. Санариптик цивилизация тилчилер үчүн жаңы профессионалдык мүмкүнчүлүктөрдү ачып, санариптик технологиялардын, интернет-ресурстардын, табигый гана эмес жасалма тилдердин да мүмкүнчүлүктөрүнүн кесилишиндеги интеграцияланган функцияларды өз ичине камтыйт.
В статье понятия «педагогическая поддержка» и «фасилитация» определяются в широком, узком, локальном и унифицированном понимании. В структуре реализации идей современной педагогической методологии уточняются понятия широкого, локального, узкого и унифицированного значений. В документе представлены понятия и содержание педагогических условий оптимизации качества решения задач развития личности студента средствами и методами персонализированного, детерминированного и требовательного педагогического сопровождения. Цифровая цивилизация открывает перед лингвистами новые профессиональные возможности и включает в себя интегрированные функции на стыке цифровых технологий, интернетресурсов и возможностей не только естественных, но и искусственных языков.
In the article, the concepts of "pedagogical support" and "facilitation" are defined in a broad, long, local and unified sense. In the structure of the implementation of modern pedagogical methodology, the concepts of broad, local, long and unified meanings are clarified. The document presents the concept and content of pedagogical conditions for optimizing the quality of solving tasks for the development of a student's personality with the means and methods of personalized deterministic and demanding pedagogical support. Digital civilization opens up new professional opportunities for linguists and includes integrated functions at the junction of digital technologies, Internet resources and opportunities of not only natural, but also artificial languages.
Evaluation of Kenten Main Substation Grounding System Based on IEEE 80-2013
Authors: Muhammad Abu Bakar Sidik  , Jambak Muhammad Irfan , Arifin Amir , Sodik Imanudin Momon , Syarifah Fitria  , Dodo Nugraha  , Muhammad Alif Wicaksono  
Published: September 2024

Grounding system in a Substation has an important role in human and equipment safety therefore the grounding system condition should always be under observation. Maintenance and evaluation regularly should be carried out in line with the possibility of fault current increasing that embark in the system and disturbances from lightning strokes. In this study, the grounding system at the Kenten substation was analysed by using an analytic calculation method and a numerical method software. The calculation was based on IEEE Std. 80-2013 (IEEE Guide for Safety in AC Substations Grounding). From the study, it was obtained that the grounding system of Kenten substation just fulfils the safety standard regulation.
How does emotional content influence visual word recognition? A meta-analysis of valence effects
Authors: Ferré Pilar , Sánchez-Carmona Alberto J. , Haro Juan , Calvillo-Torres Rocío , Albert Jacobo , Hinojosa José Antonio 
Published: September 2024

AbstractResearch on the interplay between language and emotion has shown evidence that the affective content of words influences their recognition. However, the direction of the effects is not clear, as there are mixed findings regarding the role of positive and, especially, negative valence. We conducted a Bayesian multi-level meta-analysis to examine the role of valence in visual word recognition, focusing on the lexical decision task. The results revealed a facilitative effect of positive valence on lexical decision times. That is, positive words led to faster responses than both negative and neutral words. In contrast, negative valence did not have any effect, although the analysis of several moderator variables suggested that there might be a facilitative effect in some cases, specifically, when negative words elicit very strong and intense emotions. These results shed light on the complexities of emotional word processing. They also point to the need for psycholinguistic models to take affective information into account, and thus provide a complete view of visual word recognition.
A Raster-oriented Method for Creating Eclipse Maps
Authors: Wright Ernie , Young C. Alex 
Published: September 2024

Abstract
Traditional total solar eclipse maps based on 19th-century calculation methods do not take full advantage of important refinements recently made possible by fast computers and high-resolution digital elevation models of both the Earth and the Moon. Ignoring the terrain of both bodies introduces errors on the order of kilometers in the ground track of the umbra and seconds in the duration and contact times of totality. While this has been understood to some degree for decades, it has not been visualized in maps until quite recently, revealing only in the last decade the surprising polygonal shape of the umbra. Beginning in December of 2016, we published maps and animations of the 2017 August 21 total solar eclipse created with a raster-oriented approach that relies on remote-sensing data sets and computer graphics techniques to produce more accurate maps and professional-quality animations. These were an important component of NASA’s public outreach for the 2017 eclipse.
FAST Survey of H i and OH Absorption toward Extragalactic Radio Sources
Authors: Chandola Yogesh , Saikia D. J. , Ma Yin-Zhe , Zheng Zheng , Tsai Chao-Wei , Li Di , Tramonte Denis , Pan Hengxing 
Published: September 2024

Abstract
Neutral atomic hydrogen and molecular gas in the host galaxies of radio active galactic nuclei can be traced using H i 21 cm and OH-1667 MHz absorption lines to understand the fueling and feedback processes. We present the results of an H i and OH absorption survey with the Five-hundred-meter Aperture Spherical radio Telescope toward 40 radio sources of low–intermediate radio luminosity (∼1023–1026 W Hz−1 at 1.4 GHz), red mid-infrared color (W2[4.6 μm]–W3[12 μm] > 2.5 mag), and redshift up to 0.35. From 13 sources with good data at H i observing frequencies, we report the detection of H i absorption toward eight sources, five of which are new detections, including four in the redshift range 0.25–0.35. Our detection rates are consistent with our previous results, with the dependence on the star formation history of the host galaxies reflected in the mid-infrared Wide-field Infrared Survey Explorer W2−W3 colors and the compactness of the radio sources. We find no significant dependence of the detection rates on radio luminosity or redshift. We also find that the H i column densities are anticorrelated with the low-frequency spectral indices (

α

150

MHz

1.4

GHz

, S

ν
∝ ν
−α
). We do not have any detections from 23 sources with good data at OH observing frequencies. However, by stacking the spectra, we estimate the 3σ upper limit of the OH column density to be 2.27 × 1014
T
ex/10 K × 1/f
c cm−2. By stacking the OH spectra for seven associated H i absorbers, we get a 3σ upper limit of 3.47 × 1014
T
ex/10 K × 1/f
c cm−2 on the OH column density and 1.78 × 10−7 on the [OH]/[H i] ratio.
A Targeted Search for Variable Gravitationally Lensed Quasars
Authors: Sheu William , Huang Xiaosheng , Cikota Aleksandar , Suzuki Nao , Palmese Antonella , Schlegel David J. , Storfer Christopher 
Published: September 2024

Abstract
We present a pipeline to identify photometric variability within strong gravitationally lensing candidates, in the Dark Energy Spectroscopic Instrument Legacy Imaging Surveys. In our first paper, we laid out our pipeline and presented seven new gravitationally lensed supernovae candidates in a retrospective search. In this companion paper, we apply a modified version of that pipeline to search for gravitationally lensed quasars. From a sample of 5807 strong lenses, we have identified 13 new gravitationally lensed quasar candidates (three of them quadruply lensed). We note that our methodology differs from most lensed quasar search algorithms that solely rely on the morphology, location, and color of the candidate systems. By also accounting for the temporal photometric variability of the posited lensed images in our search via difference imaging, we have discovered new lensed quasar candidates. While variability searches using difference imaging algorithms have been done in the past, they are typically performed over vast swathes of the sky, whereas we specifically target strong gravitationally lensed candidates. We also have applied our pipeline to 655 known gravitationally lensed quasar candidates from past lensed quasar searches, of which we identified 13 that display significant variability (one of them quadruply lensed). This pipeline demonstrates a promising search strategy to discover gravitationally lensed quasars in other existing and upcoming surveys.
A Kinetic-magnetohydrodynamic Model with Adaptive Mesh Refinement for Modeling Heliosphere Neutral-plasma Interaction
Authors: Chen Yuxi , Toth Gabor , Powell Erick , Arshad Talha , Bair Ethan , Kornbleuth Marc , Opher Merav 
Published: September 2024

Abstract
The charge exchange between the interstellar medium and the solar wind plasma is crucial for determining the structures of the heliosphere. Since both the neutral-ion and neutral–neutral collision mean free paths are either comparable to or larger than the size of the heliosphere, the neutral phase space distribution can deviate far away from the Maxwellian distribution. A kinetic description for the neutrals is crucial for accurately modeling the heliosphere. It is computationally challenging to run three-dimensional time-dependent kinetic simulations due to the large number of macroparticles. In this paper, we present the new highly efficient Solar Wind with Hydrogen Ion Exchange and Large-scale Dynamics-2 model with a kinetic model of neutrals and a magnetohydrodynamic model for the ions and electrons. To improve the simulation efficiency, we implement adaptive mesh refinement and particle splitting and merging algorithms for the neutral particles to reduce the particle number that is required for an accurate simulation. We present several tests to verify and demonstrate the capabilities of the model.
Observational Evidence of Particle Acceleration by Relativistic Magnetic Reconnection in Gamma-Ray Bursts
Authors: Peng Cheng-Feng , Lu Rui-Jing , Liang Wen-Qiang , Chen Zhe-geng 
Published: September 2024

Abstract
Gamma-ray bursts (GRBs) as the most energetic explosions in the modern universe have been studied for over half a century, but the physics of the particle acceleration and radiation responsible for their observed spectral behaviors are still not well understood. Based on the comprehensive analysis of the pulse properties in both bright GRB 160625B and GRB 160509A, for the first time, we identify evidence of particle acceleration by relativistic magnetic reconnection from the evolutionary behavior of the two spectral breaks E
p and E
cut. Meanwhile, the adiabatic cooling process of the emitting particles in the magnetic reconnection regions produces a relation between the spectral index and the flux. We also discuss the physics behind spectral energy correlations. Finally, we argue that the identification of an anticorrelation between E
cut and L
iso may open a new avenue for diagnostics of the physics of the particle acceleration and radiation in a variety of astrophysical sources.
Three Types of Solar Coronal Rain during Magnetic Reconnection between Open and Closed Magnetic Structures
Authors: Qiao Fangfang , Li Leping , Tian Hui , Hou Zhenyong , Song Hongqiang , Ji Kaifan , Sun Zheng 
Published: September 2024

Abstract
Coronal rain (CR) is a crucial part of the mass cycle between the corona and chromosphere. It includes flare-driven CR and two types of quiescent CR, along nonflaring active region closed loops and along open structures, separately, labeled as type I, type II, and type III CR, respectively. Among them, type I and type III CR are generally associated with magnetic reconnection. In this study, employing data taken by the Solar Dynamics Observatory and the Solar Upper Transition Region Imager on 2022 October 11, we report three types of CR during an interchange reconnection between open and closed magnetic field structures above the southeastern solar limb. The open and closed structures converge, with the formation of the current sheet at the interface, and reconnect. The newly formed closed and open structures then recede from the reconnection region. During the reconnection, coronal condensation occurs along the reconnecting closed loops and falls toward the solar surface along both loop legs, as type II CR. Subsequently, condensation happens in the newly formed closed loops and moves down toward the solar surface along both loop legs, as type I CR. Magnetic dips of the reconnecting open structures form during the reconnection. In the dips, condensation occurs and propagates along the open structures toward the solar surface as type III CR. Our results suggest that the reconnection rate may be crucial for the formation of type I and type III CR during reconnection.