bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive experience in treating patients with Duchenne muscular dystrophy caused by a nonsense mutation: family clinical case
Authors: Kraeva L. S. , Fadeeva E. V. 
Published: September 2024

Duchenne muscular dystrophy is a severe genetic disease caused by mutations in the dystrophin gene (DMD), which lead to a significant decrease or complete absence of the protein of the same name in muscle fibers. The disease manifests itself in boys from the age of 2–5 years in the form of progressive muscular weakness, cardiomyopathy and respiratory failure. As a result of progression, patients lose the ability to move by adolescence and die in the third decade from cardiopulmonary complications. However, timely pathogenetic therapy for Duchenne muscular dystrophy can prolong the life of patients and improve its quality. In this regard, early diagnosis of the disease and early initiation of pathogenetic therapy are very important.The article describes two clinical cases of the disease in siblings with onset at 2 years of age and different ages of diagnosis. Pathogenetic therapy in the first case made it possible to prolong the patient’s outpatient stay and improve the quality of life, and early diagnosis and initiation of pathogenetic therapy in the second case avoided disease progression and contributed to the development of new motor skills. The presented clinical case demonstrates the need for early diagnosis of the disease even before the onset of clinical manifestations.
Effectiveness of an object moving depending on its orientation in the environment: a kinematic analysis of motor planning and execution
Authors: Vyazmin A. O. , Ragimova A. A. , Si G. L. , Behera S. , Shevtsov O. I. , Feurra M. 
Published: September 2024

Background. Grasping objects with the hand is one of the most common movements in everyday life. It requires training involving the cognitive processes of goal selection and motor planning.Aim. To investigate the effect of object rotation on motor planning using an experiment where participants moved abstract objects that sometimes required rotation, and movement was assessed using a kinematic analysis system. We hypothesized that reaction times and movements would be longer for tasks with rotation.Materials and methods. Sixteen subjects participated in the study (11 females and 5 males), mean age – 23.375 ± 2.277 years. Participants were required to perform a task of moving 4 abstract objects onto corresponding platforms with their right hand, while periodically rotating the object by 90°, 180°, or 270°. The motion tracking system monitored the movement of trackers located on the subject’s right thumb and index finger, on the subject’s right wrist, and on the object and the subject’s special glasses.Results. To assess the effect of object rotation on motor planning, the data were grouped according to the angle of rotation. A one-factor analysis of variance with repeated measures was used. The results showed statistically significant differences:total movement time as a function of turning angle: F(3.45) = 5.014, p = 0.004;time to reach the grasping target: F(3.45) = 61.79, p = 0.001;object motion time: F(3.45) = 14.641, p = 0.001;time to reach maximum capture aperture: F(3.45) = 8.559, p = 0.001.Conclusion. Overall, our results support the hypothesis that object rotation during movement affects both the preparation and execution of the movement itself. The planning and executing the movement with the object rotated 180° was easier and faster than with 90° and 270° rotations. The testing allows distinguishing the stages of planning and preparation of the movement from the execution of the movement itself. Using this approach in patients with central nervous system lesions helps to assess and monitor the state of motor function, which is important for monitoring the recovery process.
Floral Morphological Variation in Black Pepper (Piper nigrum L.) Varieties and Hybrid Lines
Authors: Wahyuni Sri , Susilowati Mariana , Sirait Nursalam , Bermawie Nurliani 
Published: September 2024

The inter-variety crossing is a promising approach to increase black pepper production. However, successful hybridization hinges on floral characteristics. This study investigated the floral morphology of diverse pepper varieties and their hybrid offspring. Eighteen genotypes, including parent varieties and F1 hybrids, were cultivated in pots under greenhouse conditions at the Indonesian Spice and Medicinal Crops Research Institute, Bogor. Flower and fruit traits were observed. Results indicated variability in spike morphology. While most ripe spikes were yellowish-green, exceptions included LH 20-1 and LH 22-1. Ciinten and LH 4-5 displayed superior spike length and fruit set, contrasting with the shorter, less productive spikes of 20-1, 22-1, and 455-N2-97. Stigma receptivity and another dehiscence coincided in Ciinten, N2BK, LH 6-2, and LH 4-5, simplifying the hybridization process. Conversely, earlier stigma receptivity in Petaling 1, Petaling 2, Natar 1, Natar 2, LH 44-9, LH 20-1, and LH 22-1 facilitated castration procedures. These findings offer valuable insights for optimizing pepper breeding programs.
Observatorios de Salud Mental: dispositivos en construcción
Authors: Campelo de Macedo Mauricio Ricardo 
Published: September 2024

Este artículo trata de la emergencia y posibilidades de los observatorios de Salud Mental y presenta los resultados de una Revisión Integrativa de la producción científica sobre el tema de los observatorios, identificando conceptos, metodologías y categorías deanálisis, instrumentos de evaluación y tecnologías de información, comunicación y producción de memoria en el campo de la Salud Mental, orientados por los principios éticos de los Derechos Humanos. Es reciente el surgimiento de observatorios de esta subárea, en particular en América Latina, la mayoría de estos volcados para monitorear situaciones y procesos de sufrimiento psíquico y trastornos mentales en las poblaciones y territorios, y el desarrollo de políticas, modelos asistenciales, prácticas y cuidados para responder a los problemas de este campo.
La macrotemática principal priorizada por estos dispositivos es la de la "reforma psiquiátrica", y estos pueden constituirse como un puesto de observación estratégico para el monitoreo del campo de la salud mental en territorios, como catalizadores de procesos colectivos, como espacios de concertación entre los actores involucrados en este campo de acción para la toma de decisiones y formulación de políticas. Asimismo, surgieron de las publicaciones analizadas macrotemáticas como: políticas de salud mental, derechos humanos y ciudadanía, gestión del cuidado, rehabilitación psicosocial, participación, epidemiología y determinantes de los problemas, evaluación y monitoreo, uso problemático de sustancias psicoactivas, salud mental de niños y adolescentes.
Las publicaciones analizadas refieren la importancia de los observatorios para la construcción y validación de indicadores, sobre todo de evaluación de las condiciones de salud mental de la población, de los cuidados y servicios ofrecidos y de las violaciones de derechos humanos, como temas de gran complejidad. Además, se destacan como fundamentales el análisis del proceso de estructuración de estos dispositivos, sus posibilidades de sustentabilidad, sus proyectos teórico-conceptuales y metodológicos y acciones desarrolladas en el campo de la Salud Mental.
La financiación, la estabilidad de su inserción institucional, la credibilidad y legitimidad ante otras instituciones y la población del territorio al que se vincula, son fundamentales para su factibilidad y viabilidad. Además de la importancia de quien opera el observa-torio, su disponibilidad, compromiso para actuar y su formación; claves para el desempeño de sus actividades con efectividad.
Um retrato sobre o conhecimento tecnológico pedagógico do conteúdo de professores de química durante a pandemia a partir do olhar discente
Authors: Bedin Everton , Cleophas Maria das Graças 
Published: September 2024

Esta pesquisa apresenta uma visão geral sobre a possível presença do perfil conceitual do Conhecimento Tecnológico Pedagógico do Conteúdo (CTPC) de professores de química durante a pandemia. Para tanto, investigou-se as concepções de 324 discentes de diferentes regiões do Brasil na busca de indícios que possam denotar predominâncias de domínios do conhecimento que compõem a estrutura CTPC. A estatística descritiva e a análise indutiva foram utilizadas para analisar os dados constituídos a partir de um questionário na escala Likert. Os achados indicam haver uma compreensão básica do domínio do Conhecimento Tecnológico pelos professores, ao invés de um conhecimento mais integrado do CTPC, bem como que os docentes demonstraram uma combinação dos conhecimentos da tecnologia, da pedagogia e do conteúdo em vez de uma integração dos três domínios necessários para formar a intersecção central do CTPC.
Slapstick in the Wayang Kulit Arena: Gender Domination Practices Lead to Symbolic Violence
Authors: Saepudin Asep , Fitriani Tri Sat , Pambayun Gandes 
Published: September 2024

<p>This paper aims to explain the phenomenon of <em>dagelan</em> dalang and sinden in Yogyakarta's shadow puppet <em>limbukan</em> scene. <em>Dagelan</em> in Wayang is a humor/joke show to entertain the audience, usually done by dalang with sinden. For some people, <em>dagelan</em> is commonplace because it is generally presented in <em>limbukan</em> scenes for entertainment. However, <em>dagelan</em> in the <em>limbukan</em> section is not just entertainment but causes symbolic exploitation of sinden by the puppeteer with his various practices. Of course, this phenomenon is very paradoxical; on the one hand, the existence of sinden is significant because it supports the success of the shadow puppet show last night, but on the other hand, sinden becomes a victim of ridicule/laughter in a helpless condition because it is dominated and controlled by the puppeteer. The audience and group members even confirmed this dominance. In <em>limbukan</em> scenes, a sinden follows the puppeteer's instructions to sing a song while standing up and dancing. In addition, sinden is also the object of entertainment and even mockery of the mastermind with verbal and nonverbal language that causes discomfort. This is symbolic violence because sinden is a victim of entertainment exploitation. The conclusion shows that the extended exploitation of the mastermind against the sinden in the <em>limbukan</em> scene occurred because of the position of the sinden in a weak place in the ownership of capital compared to the mastermind. Sinden, however, is a part of the domination by the mastermind. On the contrary, puppeteers have various capital to become the dominant class with dominance and power. This leads to symbolic violence by the mastermind against Sinden and can even lead to mental violence.</p>
Ideological narratives of liberalism and socialism
Authors: Volchik V. V. , Shiriaev I. M. 
Published: September 2024

Objective: to compare the ideologies of liberalism and socialism in economic science in the context of the current stage of their evolution. For this purpose, the paper identifies the goals of these ideologies by analyzing the scientific narratives of economists. The study is also aimed at identifying similarities and differences between the ideologies of liberalism andsocialism. Methods: qualitative methods, narrative analysis, review of scientific literature. Results: the comparison of common interpretations of the “ideology” concept in various branches of economics and in other social sciences shows differences in terminology. The comparison of the liberalism and socialism ideologies in economics shows the difference between the declared goals of liberals and socialists. The goal of liberalism ideology is human freedom,and of socialism ideology – distribution equality. The ideologies considered are internally heterogeneous and have evolved over time. At present, liberalism is continued in neoliberalism, which aims at increasing the population wealth rather than freedom as an end in itself. There are non-egalitarian interpretations of the essence of socialism, which reduce it to the economy governmentalization. There are also debates about the advantages of the market over centralized planning in socialism. The extremes of the ideologies of liberalism and socialism can be clearly distinguished, but in practice, many studies take an intermediate position. A common feature of liberalism and socialism is their modernist character and criticism of archaic economic institutions designed to redistribute wealth from the poor to the rich. Scientific novelty: it consists in identifying the economic goals proclaimed by the ideologies of liberalism and socialism, based on the analysis of the relevant theoretical narratives in scientific literature. Practical significance: it is determined by the need to understand the factors influencing the economists’ worldview. Studying the ideologies of liberalism and socialism is useful for understanding the intent of the authors of recommendations for improving the institutions of the modern Russian economic order.
New approach to researching the development level of the creatosphere in human-centered economy in Russia
Authors: Nasyrova S. I. 
Published: September 2024

Objective: to develop conceptual provisions of human-centered economy by forming a new approach to the study of the creatosphere as a constituent element of the said economic system in order to develop its management. Methods: analysis, synthesis, content analysis, scheme of contradiction, linear scaling method, minimax normalization. Results: the characteristic of the creatosphere of the human-centered economy is revealed from the viewpoint of satisfying the individual’s needs in creativity; the creatosphere structure is analyzed as an element covering all spheres of the economic system under consideration; the model of homeostasis of the human-centered economy is developed through identifying its elements-opposites (on the one hand – natural and material spheres, services, social sphere, infosphere, digital and cognitive spheres, on the other hand – creatosphere), as well as the model of the basic resource (flow of ideas) and regulator (human needs); the predetermining role of the creatosphere in the development of the said economic system is outlined; the contradictions are revealed at the level of human-centered economy, the resolution of which contributes to the development of an individual and the economic system as a whole. Scientific novelty: it consists in the development of a methodology for assessing the creatosphere and testing it on the Russian subjects. Unlike those available in the literature, the methodology allows comprehensively assessing the creatosphere development as an element that affects the human-centered economy as a whole. The novelty consists also in defining a vector in the creatosphere management based on the formed approach to its research through the upscaling of best regional practices. Practical significance: the results of comprehension of the human-centered economy creatosphere through the scheme of contradictions may serve as a basis for further research in order to build a scientifically sound theory of the said economic system and to form directions for resolving the identified contradictions. The study results are the basis to further define the development level of the Russian human-centered economy in order to develop measures for its effective management.
Subsidizing as a tool to ensure economic sovereignty: a quantitative analysis
Authors: Kapoguzov E. A. , Gordeev V. A. , Pakhalov A. M. 
Published: September 2024

Objective: to assess the relationship between the basic monetary instrument of state support for industry – subsidies – and basic macro-indicators of its effectiveness in the context of economic sovereignty. Methods: content analysis of publications, statistical analysis of macroeconomic indicators, econometric analysis on a wide sample of countries. Results: 1) the analysis of mentioning the category “subsidies” in Russian, English and Chinese printed publications confirmed the high interest to subsidies in China; 2) the analysis of correlation between the level of subsidies and the basic macro-indicators by countries on IMF data showed statistically significant correlations of the level of subsidies with the level of current account balance (low correlation) and GDP per capita (moderate correlation); 3) the evaluation showed no significant relationship between the level of subsidies and GDP per capita. According to the study results, conclusions were drawn about the absence of dependence between the level of transfers provided and the decrease of dependence on import. Scientific novelty: the hypothesis was checked that the level of subsidies in the state has a statistically significant impact on the country’s current account balance. The model is based on earlier studies with the added analysis of the role of subsidies in reaching the economic development goals. The novelty of this study consists in the absence of a significant relationship between the level of subsidies and the current account balance. Practical significance: the study results can be useful to specialists in the field of industrial policy. They provide a basis for a fuller understanding of the tools to ensure technological sovereignty. Modifications of the regression model can be used in further studies of the factors of the current account balance.
Digital Transformation, Green Transformation and Corporate Risk Taking——Evidence from ChiNext Listed Companies
Authors: Wang Juan , Kharuddin Khairul Ayuni Binti Mohd , Ismail Rina Fadhilah Binti 
Published: September 2024

Abstract

China's economic development is significantly advancing through digital and green synergy transformation. ChiNext listed companies have the traits of higher growth and higher innovation, which lead to smoother and easier corporate digital and green synergy transformation. Corporate digital transformation and corporate green transformation have a profound impact on the operation and management activities of companies and have become important factors affecting corporate risk taking. Based on the samples of ChiNext listed companies from 2012 to 2022, this paper examines the impact of digital and green synergy transformation on corporate risk taking. This paper draws the following conclusions: Both digital transformation and green transformation significantly enhance corporate risk taking, and dual synergy transformation significantly enhances corporate risk taking. Further research shows that compared with state-owned companies, non-state-owned companies ' dual transformation have more significant influence on corporate risk taking. Compared with labor-intensive companies, the synergy transformation of capital-intensive companies and technology-intensive companies significantly promotes corporate risk taking. These conclusions have certain practical significance for promoting dual synergy transformation of companies and improving corporate risk taking behavior.
DDX3X aggravates neuronal pyroptosis and inhibits autophagy via NLRP3 inflammasome after experimental subarachnoid hemorrhage
Authors: Hao Guangzhi , Wang Yiwei , Huan Yu , Han Yuwei , Shi Zuolin , Yang Xinyu , Dong Yushu , Pan Pengyu , Liang Guobiao 
Published: September 2024

Abstract

Neuronal cell death was considered as the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism was still unclear. DDX3X, a member of DEAD-box helicase family, has a major effect on many biological processes, such as immune inflammation, growth and development, by mediating RNA metabolism. Recent study reported that DDX3X regulated the balance of NLRP3 inflammasome and stress granules in stress condition, but the role of DDX3X in SAH was still unknown. Therefore, we conduced the in-vivo and in-vitro experiments for the role and mechanism of DDX3X in SAH. Western blot and immunofluorescence showed that SAH promoted DDX3X expression, especially in the cortical neurons. After up-regulation of DDX3X, NLRP3 inflammasome was activated and autophagy was inhibited, resulting in the neurological dysfunction and damage of blood brain barrier. Further rescue experiments confirmed that DDX3X aggravated neuronal pyroptosis and inhibited autophagy via NLRP3 inflammasome after SAH. Hence, DDX3X might be a potential therapeutic target for early brain injury of SAH.
Host-induced gene silencing of specific genes of Plasmodiophora brassicae as an approach to control clubroot disease
Authors: Yang Hui , Zhang Y.H. , Zhao Y.S. , Shu Y.P. , Xu Y.S. , Du Junbo 
Published: September 2024

Abstract

Clubroot disease, caused by the biotrophic pathogen Plasmodiophora brassicae, poses a significant threat to global cruciferous crops production. Current prevention and control strategies are ineffective against P. brassicae. Therefore, new control approach is needed. We have identified two putative effectors, Pb48 and Pb52, which possess secretory functions and exert influence on plant defense. Instantaneous expression of hairpin RNAi constructs with sequence homology to P. brassicae effector Pb48 or Pb52 was performed in Brassica rapa. The successful expression in host and their uptake by P. brassicae were confirmed through observation of green fluorescence in root hair and root epidermal cells as well as within P. brassicae zoosporangia. Successful silencing of either Pb48 or Pb52 resulted in reduced root gall size and enhanced resistance of the host to P. brassicae infection. Especially, silencing of Pb48 led to a decrease in zoosporangia numbers within root hair and epidermal cells. Silencing either Pb48 or Pb52 also resulted in decreased expressions of cytokinin biosynthesis gene IPT1 and auxin homeostasis GH3.5 associated with hormone regulation pathways involved in clubroot development. The transient expression of short interfering RNAs from P. brassicae demonstrates its potential as an effective strategy against this pathogen, thereby paving the way for future developments that confer disease resistance to susceptible host.
Comparison of air pollution before, during, and after restrictions on the activities of residents to prevent the transmission of COVID-19 in Jakarta, Indonesia
Authors: Raksanagara Ardini Saptaningsih , Hilfi Lukman , Rinawan Fedri Ruluwedrata , Ma’ruf Tisa Layalia Hanifah , Khoerotunnisya Desie 
Published: September 2024

Abstract

The study aimed to compare air pollution levels in Jakarta, Indonesia before, during, and after the implementation of COVID-19-related restrictions on residents' activities. Data on air quality indicators such as PM2.5, PM10, nitrogen dioxide, and sulfur dioxide were collected and analyzed. The findings revealed significant variations in air pollution levels in response to the restrictions. Before the restrictions, air pollution levels were notably higher, attributed to increased industrial and vehicular activities. During the restrictions, there was a substantial decline in air pollution levels as a result of reduced human activities and transportation. After the restrictions were eased, air pollution levels began to rise again, albeit not reaching the same high levels as before. The study provides valuable insights into the impact of human activities on air quality and emphasizes the potential benefits of implementing policies to reduce air pollution. The findings contribute to the understanding of the environmental consequences of societal changes during the COVID-19 pandemic and have implications for future urban planning and air quality management in Jakarta.