bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bactericidal and antimicrobial effects of pure titanium and titanium alloy treated with short-term, low-energy UV irradiation
Authors: Itabashi T. , Narita K. , Ono A. , Wada K. , Tanaka T. , Kumagai G. , Yamauchi R. , Nakane A. , Ishibashi Y. 
Published: March 2017

Objectives The surface of pure titanium (Ti) shows decreased histocompatibility over time; this phenomenon is known as biological ageing. UV irradiation enables the reversal of biological ageing through photofunctionalisation, a physicochemical alteration of the titanium surface. Ti implants are sterilised by UV irradiation in dental surgery. However, orthopaedic biomaterials are usually composed of the alloy Ti6Al4V, for which the antibacterial effects of UV irradiation are unconfirmed. Here we evaluated the bactericidal and antimicrobial effects of treating Ti and Ti6Al4V with UV irradiation of a lower and briefer dose than previously reported, for applications in implant surgery. Materials and Methods Ti and Ti6Al4V disks were prepared. To evaluate the bactericidal effect of UV irradiation, Staphylococcus aureus 834 suspension was seeded onto the disks, which were then exposed to UV light for 15 minutes at a dose of 9 J/cm2. To evaluate the antimicrobial activity of UV irradiation, bacterial suspensions were seeded onto the disks 0, 0.5, one, six, 24 and 48 hours, and three and seven days after UV irradiation as described above. In both experiments, the bacteria were then harvested, cultured, and the number of colonies were counted. Results No colonies were observed when UV irradiation was performed after the bacteria were added to the disks. When the bacteria were seeded after UV irradiation, the amount of surviving bacteria on the Ti and Ti6Al4V disks decreased at 0 hours and then gradually increased. However, the antimicrobial activity was maintained for seven days after UV irradiation. Conclusion Antimicrobial activity was induced for seven days after UV irradiation on both types of disk. Irradiated Ti6Al4V and Ti had similar antimicrobial properties. Cite this article: T. Itabashi, K. Narita, A. Ono, K. Wada, T. Tanaka, G. Kumagai, R. Yamauchi, A. Nakane, Y. Ishibashi. Bactericidal and antimicrobial effects of pure titanium and titanium alloy treated with short-term, low-energy UV irradiation. Bone Joint Res 2017;6:108–112. DOI: 10.1302/2046-3758.62.2000619.
O PROCESSO DE CONSTRUÇÃO IDENTITÁRIA EM ORGANIZAÇÕES: UMA RELEITURA SOBRE IDENTIDADE
Authors: Vieira Colares André Felipe , Saraiva Luiz Alex Silva 
Published: March 2017

O presente caso de ensino busca explorar o estudo das identidades pessoal, social, no trabalho e nas organizações. A identidade pessoal não é constituída apenas pelas escolhas isoladas dos indivíduos, tendo o contexto, os agentes sociais e as instituições grande influência neste processo. E é com base na história da vida de Marko Zikyr que este trabalho se desenvolve. Aos seus vinte e poucos anos e homossexual, foi aprovado em um processo seletivo de uma multinacional com escritório na capital mineira. Passados alguns meses nesse
novo contexto, Marko pôde começar a constituir-se – sua identidade pessoal começa a criar traços de emancipação. Seu comportamento, modo de se portar e visão do ser gay se modificaram. No entanto, em seu trabalho, a organização não aceitava que empregados em altos cargos fossem homossexuais, de maneira a “preservar” a imagem da empresa. Marko passou então a viver um dilema – “parecer” ou “não parecer” gay, eis a questão – que ia além da sua imagem, e dizia respeito à sua própria identidade. Após diversas situações, para continuar o emprego, Marko aceitou as condições impostas por seu superior, adequando-se à
heteronormatividade.
Information Acquisition in Vertical Relations
Authors: Baake Pio , Harasser Andreas , Heiny Friederike 
Published: March 2017

Abstract
We analyse a simple supply chain with one supplier, one retailer and uncertainty about market demand. Focusing on the incentives of the supplier and the retailer to enhance their private information about the actual market conditions, we show that choices on information acquisition are strategic complements. While the retailer’s incentives are mainly driven by the information rent that he can earn, the supplier will choose to acquire information only if the retailer is rather well informed, even though the information is free of charge.
A note on the Hilali conjecture
Authors: Amann Manuel 
Published: March 2017

Abstract
In this short note we observe that the Hilali conjecture holds for 2-stage spaces, i.e. we argue that the dimension of the rational cohomology is at least as large as the dimension of the rational homotopy groups for these spaces. We also prove the Hilali conjecture for a class of spaces which puts it into the context of fibrations.
An answer to a conjecture on an integral sequence
Authors: Gavrea Ioan , Ivan Mircea 
Published: March 2017

Abstract
We answer a conjecture and an open problem
concerning integral sequences of the form

∫
0
1

f
⁢

(
x
)

⁢
f
⁢

(

x
2

)

⁢
⋯
⁢
f
⁢

(

x
n

)

⁢

d
x

n

,
n

≥
2

.

\sqrt[n]{\int_{0}^{1}f(x)f(x^{2})\cdots f(x^{n})\,\mathrm{d}x},\quad n\geq 2.
Effect of the Basicity on the Crystallization Behavior of Titanium Bearing Blast Furnace Slag
Authors: Meilong Hu , Ruirui Wei , Leizhang Gao , Lu Liu , Chenguang Bai 
Published: March 2017

AbstractBasicity of titanium bearing blast furnace (BF) slag is critical for its crystallization behavior. Thermodynamics calculation indicates that rutile is the main phase after crystallization (or at room temperature). It precipitates during the cooling when the basicity of the slag is lower than 0.7. With increasing basicity, perovskite appears and becomes the main phase instead which contains titanium. Crystallization temperature of perovskite is higher than that of rutile and the other phases. Namely, perovskite crystallizes firstly from the molten slag during decreasing temperature. XRD analysis shows that CaTi21O38 is the main phase with a basicity of 0.6. CaMg0.39Al0.87Ti0.48Si1.26O6, CaTiSiO5 and CaMgSi2O6 are the main crystallization phases with a basicity of 0.8. The difference between experimental and thermodynamics calculation is due to the complicate crystallization behavior of the multiple slag under super cooling rate. When the slag basicity increases to 1.1, the main precipitatied phase is perovskite, which agrees well with theory calculation. In addition, the crystal structure of the synthesized titanium bearing slag is basically similar regardless of the basicity.
The results of interconnection of the evidence of professional exposure to genotoxic factors (regex) and cancer registry in the Czech Republic
Authors: Lehocká Hana , Závacká Ivona , Vavrošová Jana , Janout Vladimír 
Published: March 2017

Abstract
The aim of this study is to analyze the genotoxic risks in the Moravian-Silesian Region in the Czech Republic and assess the significance of genotoxic factors in the etiology of cancer by bringing together the Registry of Occupational Exposure to Genotoxic Factors and the Cancer Registry and compare the rate of detected cancer in persons exposed to genotoxic factors via their work in the Moravian-Silesian Region with the occurrence of cancer in the population of the Czech Republic. The results show: (a) For the monitored group (748 person) for the period 1996–2008, according to gender, was no statistically significant difference in the incidence of oncological diseases compared to the population of the Czech Republic. (b) But statistically significant difference was found in the cases of oncological diseases in groups according to % AB.C. using the Cytogenetic analysis of human peripheral lymphocytes (CAPL). The highest incidence was in the group with a higher incidence of % AB.C. High values of % AB.C. may predict the development of oncological diseases.
The robustness of generalized random Bayesian abstract fuzzy economy models
Authors: Saipara Plern , Kumam Poom 
Published: March 2017

Abstract
In the present article, we study an economic model that was suggested by Anderlini and Canning and which applies to a class of generalized Bayesian abstract fuzzy economy for product measurable spaces together with a related abstract rationality function. We prove that this model is structurally stable which implies that it is robust to ε-equilibria.
Reflected solutions of generalized anticipated backward double stochastic differential equations
Authors: Xu Liping , Li Zhi , Luo Jiaowa 
Published: March 2017

Abstract
In this paper, we deal with a new type of differential equations called
generalized anticipated backward doubly stochastic differential equations (GA-BDSDEs).
The coefficients of these BDSDEs depend on the future value of the solution

(
Y
,
Z
)

${(Y,Z)}$

.
We obtain an existence and uniqueness theorem and a comparison theorem for the reflected solutions of these equations.
On the mechanisms of modal damping in FRP/honeycomb sandwich panels
Authors: Abbasloo Aslan , Maheri Mohamad Reza 
Published: March 2017

AbstractSandwich panels made of fibre-reinforced plastic (FRP) skins and a honeycomb core can be effectively damped through the choice of the skin and especially of the core materials. Because the core is often highly damped, a lateral deflection that causes more shearing of the core than bending of the skin increases sandwich damping. Aside from the skin and the core material properties, the shearing/bending ratio depends on a number of other, often interacting, factors, including the sandwich planar as well as transverse dimensions, the particular modal pattern in which the panel vibrates and its relationship to the type of skin layup, as well as the panel end conditions. In the present work, using a simple, first-order shear deformation theory, damping results have been produced for simple modes of vibration of a sandwich panel comprising composite skins and a damped honeycomb core, demonstrating the mechanisms by which the above factors affect the FRP skin/honeycomb core sandwich damping.
Computer-aided design of aptamers for SMMC-7721 liver carcinoma cells
Authors: Yu Xinliang , Deng Jiyong , Guo Qiuping 
Published: March 2017

Abstract

Objective
A pattern recognition model was developed for aptamers against SMMC-7721 by applying the support vector machine (SVM) algorithm. Subsequently, according to computer-aided aptamer design, eight DNA aptamer sequences were synthesized and tested.

Methods
Candidate aptamer sequences selected for SMMC-7721 liver carcinoma cells were obtained with whole cell-SELEX. Their reverse-complement sequences were used for descriptor calculation to develop structure-activity relationships (SAR) model. SVM was adopted for the pattern recognition for candidate aptamer sequences with high or low affinity against SMMC-7721 liver carcinoma cells. By the model predictions, we designed, synthesized and tested eight DNA aptamer sequences against SMMC-7721.

Results
Five molecular descriptors from reverse-complement sequences were obtained to develop the SAR model of pattern recognition. The predicted fractions of winner aptamers with high affinity for the 3rd, 5th, 7th, 9th, 11th, and 13th rounds of SELEX selection are 0.09, 0.17, 0.69, 0.84, 0.90 and 0.98, respectively. Their fitting curve and the corresponding exponential equation conform to the aptamer evolutionary principles of SELEX based screening. These new designed sequences belonging to the class of sequences with high binding affinity have experimental dissociation constants K
d in the nanomolar range.

Conclusion
The feasibility of applying computer-aided aptamer design has been demonstrated.
Using Quality Improvement to Introduce and Standardize the National Early Warning Score (NEWS) for Adult Inpatients at a Children’s Hospital
Authors: Conway-Habes Erin E. , Herbst Brian F. , Herbst Lori A. , Kinnear Benjamin , Timmons Kristen , Horewitz Deborah , Falgout Rachel , O’Toole Jennifer K. , Vossmeyer Michael 
Published: March 2017

INTRODUCTION:
The population of adults with childhood-onset chronic illness is growing across children’s hospitals and constitutes a high risk population. National Early Warning Score (NEWS) is among the most recently validated adult early warning scores (EWSs) for early recognition of and response to clinical deterioration. Our aim was to implement and standardize NEWS scoring in 80% of patients age 21 and older admitted to a children’s hospital.

METHODS:
Our intervention was tested on a single unit of our children’s hospital. The primary process measure was the percentage of NEWS documented within 1 hour of routine nursing assessments, and was tracked using a run chart. Improvement activities focused on effective training, key stakeholder buy-in, increased awareness, real-time mitigation of failures, accountability for adherence, and action-oriented response. We also tracked the distribution of NEWS values and medical emergency team calls.

RESULTS:
The percentage of NEWS documented with routine nursing assessments for patients age 21 and over increased from 0% to 90% within 15 weeks and remained at 77% or greater for 17 weeks. Our distribution of NEWS values was similar to previously reported NEWS distribution.

CONCLUSIONS:
A nurse-driven adult early warning system for inpatients age 21 and older at a children’s hospital can be achieved through a standardized EWS assessment process, incorporation into the electronic health record, and charge nurse and key stakeholder oversight. Furthermore, implementation of an adult EWS being used at a pediatric institution and our distribution of NEWS values were comparable to distribution published from adult hospitals.
Effectiveness of Fundoplication or Gastrojejunal Feeding in Children With Neurologic Impairment
Authors: Stone Bryan , Hester Gabrielle , Jackson Daniel , Richardson Troy , Hall Matt , Gouripeddi Ramkiran , Butcher Ryan , Keren Ron , Srivastava Rajendu 
Published: March 2017

BACKGROUND AND OBJECTIVES:Gastroesophageal reflux (GER), aspiration, and secondary complications lead to morbidity and mortality in children with neurologic impairment (NI), dysphagia, and gastrostomy feeding. Fundoplication and gastrojejunal (GJ) feeding can reduce risk. We compared GJ to fundoplication using first-year postprocedure reflux-related hospitalization (RRH) rates.METHODS:We identified children with NI, dysphagia requiring gastrostomy tube feeding and GER undergoing initial GJ placement or fundoplication from January 1, 2007 to December 31, 2012. Data came from the Pediatric Health Information Systems augmented by laboratory, microbiology, and radiology results. GJ placement was ascertained using radiology results and fundoplication by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Subjects were matched within hospital using propensity scores. The primary outcome was first-year postprocedure RRH rate (hospitalization for GER disease, other esophagitis, aspiration pneumonia, other pneumonia, asthma, or mechanical ventilation). Secondary outcomes included failure to thrive, death, repeated initial intervention, crossover intervention, and procedural complications.RESULTS:We identified 1178 children with fundoplication and 163 with GJ placement, matching 114 per group. Matched sample RRH incident rate per child-year (95% confidence interval) for GJ was 2.07 (1.62–2.64) and for fundoplication 1.67 (1.28–2.18), P = .19. Odds of death were similar between groups. Failure to thrive, repeat of initial intervention, and crossover intervention were more common in the GJ group.CONCLUSIONS:In children with NI, GER, and dysphagia: fundoplication and GJ feeding have similar RRH outcomes. Either intervention can reduce future aspiration risk; the choice can reflect non-RRH-related complication risks, caregiver preference, and clinician recommendation.
Development and Testing of the

P

ediatric

R

espiratory

I

llness

Me

asurement

S

ystem (PRIMES) Quality Indicators
Authors: Mangione-Smith Rita , Roth Carol P. , Britto Maria T. , Chen Alex Y. , McGalliard Julie , Boat Thomas F. , Adams John L. , McGlynn Elizabeth A. 
Published: March 2017

OBJECTIVES:
To develop and test quality indicators for assessing care in pediatric hospital settings for common respiratory illnesses.

PATIENTS:
A sample of 2796 children discharged from the emergency department or inpatient setting at 1 of the 3 participating hospitals with a primary diagnosis of asthma, bronchiolitis, croup, or community-acquired pneumonia (CAP) between January 1, 2010, and December 31, 2011.

SETTING:
Three tertiary care children’s hospitals in the United States.

METHODS:
We developed evidence-based quality indicators for asthma, bronchiolitis, croup, and CAP. Expert panel–endorsed indicators were included in the Pediatric Respiratory Illness Measurement System (PRIMES). This new set of pediatric quality measures was tested to assess feasibility of implementation and sensitivity to variations in care. Medical records data were extracted by trained abstractors. Quality measure scores (0–100 scale) were calculated by dividing the number of times indicated care was received by the number of eligible cases. Score differences within and between hospitals were determined by using the Student’s t-test or analysis of variance.

RESULTS:
CAP and croup condition-level PRIMES scores demonstrated significant between-hospital variations (P &lt; .001). Asthma and bronchiolitis condition-level PRIMES scores demonstrated significant within-hospital variation with emergency department scores (means [SD] 82.2(6.1)–100.0 (14.4)] exceeding inpatient scores (means [SD] 71.1 (2.0)–90.8 (1.3); P &lt; .001).

CONCLUSIONS:
PRIMES is a new set of measures available for assessing the quality of hospital-based care for common pediatric respiratory illnesses.
Social skills deficits and their association with Internet addiction and activities in adolescents with attention-deficit/hyperactivity disorder
Authors: Chou Wen-Jiun , Huang Mei-Feng , Chang Yu-Ping , Chen Yu-Min , Hu Huei-Fan , Yen Cheng-Fang 
Published: March 2017

Background and aims
The aims of this study were to examine the association between social skills deficits and Internet addiction and activities in adolescents with attention-deficit/hyperactivity disorder (ADHD) as well as the moderators for this association.

Methods
A total of 300 adolescents, aged between 11 and 18 years, who had been diagnosed with ADHD participated in this study. Their Internet addiction levels, social skills deficits, ADHD, parental characteristics, and comorbidities were assessed. The various Internet activities that the participants engaged in were also examined.

Results
The associations between social skills deficits and Internet addiction and activities and the moderators of these associations were examined using logistic regression analyses. Social skills deficits were significantly associated with an increased risk of Internet addiction after adjustment for the effects of other factors [odds ratio (OR) = 1.049, 95% confidence interval (CI) = 1.030–1.070]. Social skills deficits were also significantly associated with Internet gaming and watching movies. The maternal occupational socioeconomic levels of the participants moderated the association between social skills deficits and Internet addiction.

Conclusions
Social skills deficits should be considered targets in prevention and intervention programs for treating Internet addiction among adolescents with ADHD.
El Problema de patrones de corte, clasificación y enfoques/Cutting stock problem, classification and approaches
Authors: Gil Gonzalez Cristiam Andres , Orejuela Cabrera Juan Pablo , Peña Diana 
Published: March 2017

Cutting stock problem abarca el tema de cortar grandes rollos de algún material (papel, textil, acero, madera, etc) en pequeñas tiras de diferentes anchos, que se utilizan como materia prima para la fabricación de un producto final. En este trabajo se presenta inicialmente una introducción de lo que significa en complejidad la solución de un problema de este tipo en una empresa. Luego se enuncian sus antecedentes mediante los trabajos más importantes encontrados en la literatura, destacando algunos trabajos Colombianos. Posteriormente, recordamos la clasificación propuesta por Dyckhoff en 1990 y se aportan sugerencias de otros aspectos a tener en cuenta cuando se aborda el Cutting stock problema. Finalmente se enmarcan los cuatro enfoques de solución más comunes dando ideas para investigaciones futuras.
Remoción de Zinc (II) de soluciones acuosas usando cáscara de yuca (Manihot esculenta): Experimentos en columna/Removal of zinc (II) from aqueous solutions using cassava peel (Manihot esculenta): column experiments
Authors: Albis Arrieta Alberto Ricardo , Martínez Jader , Santiago Pablo 
Published: March 2017

Se realizó un estudio en una columna de lecho fijo a escala de laboratorio para determinar el comportamiento del tiempo de ruptura para la adsorción de Zinc (II) en soluciones acuosas usando como lecho cáscara de yuca (Manihot esculenta), la cual fue pretratada y posteriormente caracterizada. Se evaluó la influencia de la variación de parámetros como la altura del lecho (7 - 23 cm), la concentración inicial de Zinc (II) (132 - 468 mg/L) y el flujo de alimentación (7 - 23 mL/min) para determinar el comportamiento del tiempo de ruptura. Los resultados de los experimentos muestran que hay un mayor rendimiento cuando se utilizan el flujo de alimentación y la concentración inicial más bajos, así como la mayor altura del lecho con cáscara de yuca. El tiempo de ruptura óptimo (25 min) se alcanza con una concentración inicial de Zinc de 480.23 mg/L, un caudal de alimentación de 23.35 mL/min y una altura de lecho de 12.86 cm, que constituyen la mejor configuración de parámetros. Adicionalmente, se determinó que el comportamiento del tiempo de ruptura puede ser completamente predicho en los rangos de interés por el modelo BDST.
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma
Authors: Hecht J. Randolph , Benson Al B. , Vyushkov Dmitry , Yang Yingsi , Bendell Johanna , Verma Udit 
Published: March 2017

Abstract

Lessons Learned
The safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group. The addition of simtuzumab to chemotherapy with FOLFIRI does not improve clinical outcomes in patients with metastatic KRAS mutant colorectal carcinoma.

Background
Simtuzumab, a humanized IgG4 monoclonal antibody to lysyl oxidase-like 2 (LOXL2), blocks desmoplastic reaction in colorectal carcinoma (CRC) cells in vitro.

Methods
Patients with metastatic Kirsten rat sarcoma viral oncogene homolog (KRAS) mutant CRC were randomized to receive second-line 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) with either 200 or 700 mg simtuzumab or placebo every 2 weeks in cycles of 28 days. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and safety were assessed.

Results
In total, 249 patients were randomized and treated with FOLFIRI/simtuzumab 700 mg (n = 84), FOLFIRI/simtuzumab 200 mg (n = 85), and FOLFIRI/placebo (n = 80). After a median follow-up of 5.1, 3.8, and 5.5 months, respectively, median PFS for each of the respective treatment groups was 5.5 months (adjusted HR [95% CI], p value versus placebo; 1.32 [0.92, 1.89]; p = .10), 5.4 months (1.45 [1.01, 2.06]; p = .04), and 5.8 months. Median OS was 11.4 months (1.23 [0.80, 1.91]; p = .25), 10.5 months (1.50 [0.98, 2.30]; p = .06), and 16.3 months, respectively. ORR was 11.9%, 5.9%, and 10%, respectively. Simtuzumab was tolerable in metastatic KRAS mutant CRC patients.

Conclusion
The addition of simtuzumab to FOLFIRI did not improve clinical outcomes in patients with metastatic KRAS mutant CRC.