bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mixed Model Approach to Genome-Wide Association Studies for Selection Signatures, with Application to Mice Bred for Voluntary Exercise Behavior
Authors: Xu Shizhong , Garland Theodore 
Published: August 2017

AbstractSelection experiments and experimental evolution provide unique opportunities to study the genetics of adaptation because the target and intensity of selection are known relatively precisely. In contrast to natural selection, where populations are never strictly “replicated,” experimental evolution routinely includes replicate lines so that selection signatures—genomic regions showing excessive differentiation between treatments—can be separated from possible founder effects, genetic drift, and multiple adaptive solutions. We developed a mouse model with four lines within a high running (HR) selection treatment and four nonselected controls (C). At generation 61, we sampled 10 mice of each line and used the Mega Mouse Universal Genotyping Array to obtain single nucleotide polymorphism (SNP) data for 25,318 SNPs for each individual. Using an advanced mixed model procedure developed in this study, we identified 152 markers that were significantly different in frequency between the two selection treatments. They occurred on all chromosomes except 1, 2, 8, 13, and 19, and showed a variety of patterns in terms of fixation (or the lack thereof) in the four HR and four C lines. Importantly, none were fixed for alternative alleles between the two selection treatments. The current state-of-the-art regularized F test applied after pooling DNA samples for each line failed to detect any markers. We conclude that when SNP or sequence data are available from individuals, the mixed model methodology is recommended for selection signature detection. As sequencing at the individual level becomes increasingly feasible, the new methodology may be routinely applied for detection of selection.
Nutritional and Albumin Content of Swamp Fishes from Merauke, Papua, Indonesia
Authors: Susilowati Rini , Sugiyono Sugiyono , Chasanah Ekowati 
Published: August 2017

Study on chemical content of swamp fishes from Merauke has been conducted to obtain nutritional status of these fishes. Sampling was conducted twice (August and November 2015) in Merauke. There were six dominant fish species, namely striped snakehead (Channa striata), nile tilapia (Oreochromis niloticus), tade gray mullet (Liza tade), philippine catfish (Clarias batrachus), barramundi (Lates calcarifer), and climbing perch (Anabas testudineus). Result on proximate analysis showed that the fishes had moisture content of 75.73±0.25%-81.45±0.04%, ash 0.94±0.01%-1.26±0.21%, protein 17.11±0.09%-18.92±0.05%, and lipid 0.59±0.19%-3.80±0.63%. The dominant essential amino acid of 6 swamp fishes from Merauke was lysine followed by leucine. Meanwhile the dominant non-essential amino acid was glutamic acid (32.26+0.61 mg/g), followed by aspartic acid. Calcium (Ca) was the dominant macro mineral for all fishes studied, being the highest was in nile tilapia (328.76±8.14 mg/100 g). Micro mineral was dominated by the presence of Selenium (Se) which the highest was in nile tilapia (0.084±0.005 mg/100g). These fishes were also rich in albumin, being the highest was stripe snakehead (138.59±1.68 mg/g). The average of total fatty acid showed that the fishes had saturated fatty acid (SFA) content of 46.30±0.27%, monosaturated fatty acid (MUFA) 9.20±1.6% and polyunsaturate fatty acid (PUFA) 34.49±0.44% of total fatty acid. From the result, it can be concluded that fish harvested from swamp of Merauke and surrounding area had a good nutritional value.
Alarm anti‐protease trappin‐2 negatively correlates with proinflammatory cytokines in patients with periodontitis
Authors: Afacan Beral , Öztürk Veli Özgen , Emingil Gülnur , Köse Timur , Bostanci Nagihan 
Published: August 2017

AbstractBackgroundTrappin‐2 is a potent biologically active serine protease inhibitor with anti‐inflammatory properties that has also been characterized as an “alarm anti‐protease.” Although the importance of trappin‐2 in several chronic infections has been demonstrated, its potential involvement in periodontitis remains undefined. This study aims to investigate salivary levels of trappin‐2 and interleukin (IL)‐1β in periodontally healthy individuals and patients with gingivitis or generalized chronic periodontitis (CP) or aggressive periodontitis (GAgP).MethodsWhole unstimulated saliva samples were collected from 80 systemically healthy and non‐smoking individuals before full‐mouth periodontal examination. Trappin‐2 and IL‐1β were analyzed by enzyme‐linked immunosorbent assay and reported as nanograms per milligram after calibration for total protein levels.ResultsCorrelation analysis revealed negative association between trappin‐2 and IL‐1β levels. Trappin‐2 also showed strong negative correlation with clinical periodontal parameters, in contrast to IL‐1β, which showed positive correlation. Trappin‐2 levels were significantly lower in individuals with CP and GAgP, but not gingivitis, compared with healthy individuals. Reduced salivary concentrations of trappin‐2 had high sensitivity and specificity to distinguish health from periodontitis.ConclusionsTrappin‐2 is abundant in the saliva of individuals with healthy periodontium in line with its role as an “anti‐alarm” protease. Decreased salivary trappin‐2 and increased IL‐1β levels in individuals with periodontitis, compared with healthy individuals, may implicate a potential antiprotease/proinflammatory cytokine imbalance, resulting in impaired host protective capacity.
How Data From Reuse of Electrical-Submersible-Pump Components Can Help in Predicting System Failure
Authors: Bailey William J. , Weir Iain S. , Couët Benoît 
Published: August 2017

SummaryA statistical study using extensions to the semiparametric survival analysis (SA) was applied to an individual component of an electrical-submersible-pump (ESP) system. Since its proposal in 1972, the Cox proportional hazards (CPH) semiparametric model (Cox 1972) has become the primary tool for regression analysis of censored data. However, CPH assumes that observations are time-independent and that censoring is noninformative.With extensions to the standard CPH formulation, we demonstrate the analysis procedure by considering a specific component of an ESP system (a motor) such that informative censoring and time-dependent variables may be accommodated. We track this motor from its first deployment, and subsequent redeployments, in different ESP systems to provide an estimate of how its reuse affects ESP run life. Exploiting such model extensions, however, demands a more-involved analysis undertaking than is typical for conventional SA studies. Model limitations and applicability are also discussed.
Measurement of Microemulsion Viscosity and Its Implications for Chemical Enhanced Oil Recovery
Authors: Tagavifar Mohsen , Herath Sumudu , Weerasooriya Upali P. , Sepehrnoori Kamy , Pope Gary 
Published: August 2017

Summary
The rheological behavior of microemulsion systems was systematically investigated with mixtures of oil, brine, surfactant, cosolvent, and in some cases polymer to determine their effects. A microemulsion-rheology model was developed and used to interpret the experimental results. The optimal microemulsion/oil-viscosity ratio without cosolvent was roughly 5:6, but it can be reduced to a more favorable ratio of approximately 2 by adding cosolvent. Even though the amount of cosolvent needed is case dependent, a clear trend of microemulsion-viscosity reduction with increasing cosolvent concentration was observed. Limited evidence suggests that large hydrolyzed polyacrylamide (HPAM) molecules with a narrow molecular-weight (MW) distribution have negligible partitioning to Type II and Type III microemulsions.
Recent Innovations in Collagen Corneal Cross-linking; a Mini Review
Authors: Vastardis Iraklis , Pajic-Eggspuehler Brigitte , Nichorlis Charis , Mueller Jörg , Pajic Bojan 
Published: August 2017

Background:
The introduction of corneal cross-linking (CXL) with ultraviolet-A (UVA) and Riboflavin photosensitizer (Vit B2) from Seiler et al., revolutionized the treatment of Keratoconus and other corneal ectatic diseases.
Today, the commonly known epithelium off Dresden protocol is in clinical use for the last 15 years with great success and regarded by many as the golden standard.

Methods:
With several studies demonstrating its simplicity, efficacy and safety this revolutionary method, paved the way for new therapies and strategies in the treatment of corneal ectatic diseases and changed our understanding in corneal biomechanics. Recent scientific and technological advances enabled the creation of various modifications of the initial CXL protocol and the formation of new ones.

Conclusion:
This work highlights the recent advances of CXL, such as the role of oxygen, higher fluence and shorter irradiation times as well as the various clinical applications and updates of this method.
Indian Influences on Balinese Culture : The Role of Hinduism and Buddhism in Present Day Bali
Authors: Ardhana I Ketut , Wijaya I Nyoman 
Published: August 2017

Indian culture has dominantly influenced the Indonesian people, particularly in the western part of the archipelago. This, which started centuries ago, can still be seen in the peoples’ daily lives in social, cultural, economic and political matters. Both the Hindu and Buddhist lessons have been practiced in Bali, although it is argued that the Buddhist lessons had been developed earlier than the Hindu ones. These developments have strongly characterized Balinese daily life, so, it is very important to understand how the people anticipate and solve some crucial issues regarding the processes of modernization and globalization. There are some important questions that need to be addressed on the Indian influences in strengthening the Balinese culture from the earlier periods until the modern and even postmodern times. In this case, the specific questions are: Firstly, how did the Balinese accept these two lessons in their daily lives in the context of Balinization processes? Secondly, what kinds of tangible and intangible cultures of the Hindu and Buddhist lessons can be seen in the present day Bali? Thirdly, how do they strengthen the Bali identity or Balinization, known as “Ajeg Bali”? Through this analysis, it is expected to have a better understanding of the issues of social, cultural, economic and political changes in Indonesia in general and Bali in particular in modern and postmodern times.
Furosemide/Fludrocortisone Test and Clinical Parameters to Diagnose Incomplete Distal Renal Tubular Acidosis in Kidney Stone Formers
Authors: Dhayat Nasser A. , Gradwell Michael W. , Pathare Ganesh , Anderegg Manuel , Schneider Lisa , Luethi David , Mattmann Cedric , Moe Orson W. , Vogt Bruno , Fuster Daniel G. 
Published: August 2017

Background and objectives
Incomplete distal renal tubular acidosis is a well known cause of calcareous nephrolithiasis but the prevalence is unknown, mostly due to lack of accepted diagnostic tests and criteria. The ammonium chloride test is considered as gold standard for the diagnosis of incomplete distal renal tubular acidosis, but the furosemide/fludrocortisone test was recently proposed as an alternative. Because of the lack of rigorous comparative studies, the validity of the furosemide/fludrocortisone test in stone formers remains unknown. In addition, the performance of conventional, nonprovocative parameters in predicting incomplete distal renal tubular acidosis has not been studied.

Design, setting, participants, & measurements
We conducted a prospective study in an unselected cohort of 170 stone formers that underwent sequential ammonium chloride and furosemide/fludrocortisone testing.

Results
Using the ammonium chloride test as gold standard, the prevalence of incomplete distal renal tubular acidosis was 8%. Sensitivity and specificity of the furosemide/fludrocortisone test were 77% and 85%, respectively, yielding a positive predictive value of 30% and a negative predictive value of 98%. Testing of several nonprovocative clinical parameters in the prediction of incomplete distal renal tubular acidosis revealed fasting morning urinary pH and plasma potassium as the most discriminative parameters. The combination of a fasting morning urinary threshold pH <5.3 with a plasma potassium threshold >3.8 mEq/L yielded a negative predictive value of 98% with a sensitivity of 85% and a specificity of 77% for the diagnosis of incomplete distal renal tubular acidosis.

Conclusions
The furosemide/fludrocortisone test can be used for incomplete distal renal tubular acidosis screening in stone formers, but an abnormal furosemide/fludrocortisone test result needs confirmation by ammonium chloride testing. Our data furthermore indicate that incomplete distal renal tubular acidosis can reliably be excluded in stone formers by use of nonprovocative clinical parameters.
Latvijas Universitātes studentes (1919–1920) – mūžīgā studenta piemērs
Authors: Rozīte Zane 
Published: August 2017

Rakstā aplūkotas 1919./1920. gadā Latvijas Universitātē iestājušās sievietes kā piemērs ilggadējo jeb mūžīgo studentu problēmai, kas bija raksturīgs augstskolas darbības aspekts. Balstoties uz gandrīz nepētītajām studenšu personas lietām, raksturoti galvenie studiju procesa pagarināšanas iemesli: augstskolas iekšējās problēmas – telpu, mācību līdzekļu, pasniedzēju trūkums, latviešu valodas prasmes, lekciju noslodze, kā arī ārējie apstākļi – ekonomiskā un sociālā situācija, ģimene, nodarbošanās, slimības. Turpinājumā aplūkota sabiedrības reakcija un risinājumi, lai novērstu studiju procesa ieilgšanu. Studijas ieilga gan vīriešiem, gan sievietēm, tomēr sievietes bija vairāk pakļautas ikdienas dzīves sociālajām un ekonomiskajām problēmām, un tas pagarināja studiju procesu ilgāk par desmit gadiem.
Ileana Rodríguez, House/garden/nation. Space, gender, and etnicity in Postcolonial Latin American literatures by women. Duke University Press, Durham-London, 1994; 223 pp.
Authors: Araújo Nara 
Published: August 2017

Se reseñó el libro: House/garden/nation. Space, gender, and etnicity in postcolonial Latin American literatures by women.
Donatella Montalto Cessi, Itinerari di Spagna. L'idea di impero nella Spagna degli "Austrias". La questione del regionalismo spagnolo. Marcos y Marcos, Milano, 1992; 77 pp.
Authors: González Aurelio 
Published: August 2017

Se reseñó el libro: Itinerari di Spagna. L'idea di impero nella Spagna degli "Austrias". La questione del regionalismo spagnolo.
Odette Bresson, Catalogue du fonds hispanique ancien (1492-1808) de la Bibliothèque Sainte-Geneviève de Paris. Préface d'Augustin Redondo. Presses de la Sorbone Nouvelle-Publications de la Sorbonne, Paris, 1994; 411 pp. (Textes et Documents du "Centre de Recherche sur l'Espagne des XVIe et XVIIe siècles [CRES]", 4).
Authors: Rodríguez González Yliana 
Published: August 2017

Se reseñó el libro: Catalogue du fonds hispanique ancien (1492-1808) de la Bibliothèque Sainte-Geneviève de Paris.
José Luis Iturrioz y Paula Gómez (eds.), Aspecto. Modos de acción. Clases de predicados. Número monográfico de la revista Función, 1993, núms. 13/14; 330 pp.
Authors: Capistrán Garza Bert Alejandra 
Published: August 2017

Se reseñó el libro: Aspecto. Modos de acción. Clases de predicados. Número monográfico de la revista Función, núms. 13/14.
Studi Penempatan Titik Pentanahan Kawat Tanah Pada Penyulang Serangan
Authors: Baskara I Wayan Agus Teja , Arjana I G Dyana , Rinas I W 
Published: August 2017

Ground wire is one of the lighning protection instrument used in medium voltage distribution network with the intention to reduce interference due to lightning strikes. On the feeder Serangan the ground wire put 4 – 5 wicket. To know effective gap of ground wire is put on the feeder Serangan then used effectiveness ground wire parameters and total of disorder by lightning strikes directly or indirectly. From the analysis is obtained the effective gap on scenario 4 by 3 – 4 wicket. Choosing scenario 4 is as effective gap because seen by economic aspect, as longest gap point put of ground wire then the cost needed to use material and the installation of ground wire will be cheaper. DOI: 10.24843/MITE.1501.05
Perbandingan Metode Extreme Learning Machine dan Particle Swarm Optimization Extreme Learning Machine untuk Peramalan Jumlah Penjualan Barang
Authors: Handika Susila , Gririantari IAD , Dharma Agus 
Published: August 2017

Extreme Learning Machine (ELM) merupakan salah satu metode pembelajaran dari Artificial Neural Network yang memberikan tingkat akurasi dan kecepatan yang lebih baik dari pada metode pembelajaran lainnya. Salah satu kelemahan dari metode ELM adalah jumlah hidden nodes ditentukan dengan cara try and error, sehingga tidak bisa diketahui berapa jumlah hidden nodes yang tepat untuk mendapatkan hasil peramalan menggunakan metode ELM. Untuk mengatasi masalah tersebut digunakan metode optimasi Particle Swarm Optimization untuk mencari jumlah hidden nodes yang optimal. Data yang digunakan untuk keperluan analisis adalah data time series penjualan barang salah satu minimarket di Bali. Hasil peramalan akan diukur mengunggunakan Mean Square Error (MSE) dengan data uji yang sama. Hasil penelitian menunjukkan metode PSO dapat diterapkan pada metode ELM untuk mengoptimasi jumlah hidden nodes. MSE yang dihasilkan oleh metode PSO ELM lebih kecil dibanding metode ELM. Selain itu range error yang dihasilkan oleh metode PSO ELM juga lebih kecil dibanding metode ELM DOI: 10.24843/MITE.1501.15
PENGEMBANGAN INFRASTRUKTUR JALAN SEBAGAI IMPLEMENTASI RENCANA TATA RUANG WILAYAH KABUPATEN KETAPANG
Authors: Juniardi Ferry , Azwansyah Heri 
Published: August 2017

Kabupaten Ketapang merupakan kabupaten yang sedang berkembang perlu didukung dengan infrstruktur jaringan jalan yang baik. Studi ini bertujuan mengembangkan infrastruktur jaringan jalan untuk mendukung pergerakan kendaraan di Kabupaten Ketapang. Studi ini membutuhkan data-data pergerakan kendaraan dan jaringan jalan yang diperoleh dari instansi terkait dan survei lapangan. Model bangkitan pergerakan kendaraan dipengaruhi oleh jumlah sarana kesehatan (X3), sedangkan model tarikan pergerakaan kendaraan dipengaruhi oleh jumlah penduduk (X1) dan jumlah sarana kesehatan(X3). Jaringan jalan arteri primer yang dikembangkan meliputi : ruas Jalan batas Kabupaten Sanggau Batas Kecamatan Balai Berkuak; ruas Jalan Batas Kecamatan Balai Berkuak Aur Kuning; ruas Jalan Aur Kuning Sandai; ruas Jalan Sandai Nanga Tayap; dan ruas Jalan Nanga Tayap Batas Provinsi Kalimantan Tengah. Sementara itu, untuk meningkatkan aksesibilitas juga dilakukan peningkatan dan pengembangan terhadap beberapa jalan kolektor primer. Ketapang regency is growing and need to be supported by a good road network infrastructure. This study aims to develop a network infrastructure to support the movement of vehicles in Ketapang regency. This study requires data of movement of vehicles and the road network, obtained from the relevant agencies/departments and field survey. Vehicles trip generation models influenced by number of health facilities (X3), while pull models of vehicle movement influenced by number of residents (X1) and number of health facilities ( X3). Primary artery roads network that was developed include: regency’s boundary road of Sanggau – district’s boundary road of Balai Bekuak; district’s boundary road of Balai Bekuak - Aur Kuning; road segment of Aur Kuning - Sandai; road segment of Sandai - Nanga Tayap, and road segment of Nang Tayap – province’s boundary of Central Kalimantan. In addition, to improve accessibility, it also necessary to makes ​​some improvement and development of the primary collector roads
PENGARUH PEMBARUAN FASAD BANGUNAN TERHADAP KARAKTER VISUAL KAWASAN, STUDI KASUS: JALAN TANJUNGPRA PONTIANAK
Authors: Misavan Derry Feriyan , Gultom Bontor Jumaylinda 
Published: August 2017

Jalan Tanjungpura merupakan kawasan yang sudah ada sejak lama di Kota Pontianak sebagai koridor yang bersisi deretan pertokoan. Sebagai kawasan yang bergerak dibidang ekonomi dan jasa perdagangan, pertokoan pada kawasan ini telah melakukan pembaruan fasad mereka sebagai pendukung untuk melancarkan usaha mereka. Namun pembaruan fasad yang dirasakan tidak terarah dan cenderung menyimpang dari citra fasad lama pada masa lalu. Maka dari itu dilakukan sebuah penelitian yang bertujuan untuk mencari karakter visual dari kawasan jalan Tanjungpura yang kemudian berguna untuk sebuah rekomendasi pengolahan fasad untuk tetap menjaga karakter visual kawasan. Penelitian ini menggunakan metode kuantitatif yang dimulai dengan acuan terhadap teori tentang karakter visual untuk kemudian di analisis dari fakta lapangan dalam mencari karakter visual kawasan yang menjadi tujuan penelitian ini. Dari hasil penelitian diperoleh temuan karakter visual kawasan Jalan Tanjungpura Pontianak adalah setiap elemen fasad memiliki pola, kesegarisan bangunan, ukuran dan bentuk yang seirama, selaras dan seimbang. Selain itu, ditemukan juga beberapa bagian bangunan yang menyimpang dari karakter visual koridor tersebut sehingga muncul sebuah rekomendasi pengolahan fasad yang ditujukan kepada pemerintah, pemilik bangunan, serta pihak terkait lainnya untuk mengembalikan karakter visual pada pada beberapa bangunan sehingga dapat menjaga kualitas visual kawasan dengan baik Tanjungpura street is an area that since longtime ago exist in Pontianak as a corridor of shopping stores . As the region engaged in the aspects of economy and trade services, this corridor used to updated their facades to support their business activities. However, this modification of facade perceived as an unfocused sight and tend to deviate from the old facade images of the past. Therefore this research conducted to find the visual character on the area of the Tanjungpura street that can be useful for façade’s recommendation to maintain the visual character of this corridor as the shopping stores. This research uses quantitative methods where the research begins with a reference to the theory of the visual character and after that the analysis is performed based on the facts of the survey datas to find the visual character of the area as the purpose of this research. Result of this research is found the visual character of the Tanjungpura street corridor derivated that each elements of the facade has a pattern, Buillding line, the size and shape with a rhythm, harmony and balance. Furthermore, there is also found some parts of the building that deviate from the visual character of it corridor that makes a recommendation of facade modification addressed to the city government, building owners and other stakeholders to redecorations visual character of several bulidings so that will maintain the quality of visual character of the area