bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Probiotic Effect towards Aspirin-induced Gastric Ulcer Healing Process as Measured by Mucous Thickness, Reepithelization, Gastric Glands Formation, and Angiogenesis in Animal Model
Authors: Lucretia Teresa , Achadiyani Achadiyani , Masria Sadeli 
Published: January 2018

Gastric Ulcer is a common side effect of Non-Steroid Anti Inflammatory Drugs (NSAIDs) use such as Aspirin. Probiotic has many benefits especially for the alimentary system, but the effect on gastric ulcer have yet to be explored. In this research we aimed to find the probiotic effect on histological structure changes during aspirin induced gastric ulcer healing process in animal model. This was simple random sampling animal experimental laboratory, that divided Wistar Rats into two main groups. Both groups were induced with Aspirin (300mg/Kg BW) per oral, once daily for three consecutive days,and subsequently the test group were given probiotic suspension (cfu >108/gr) per oral, once daily, for 14 days. Each subgroups were sacrified serially at day 0, 3, 7, 14. The gaster were collected and processed for histology examination. Better histological structures were shown in the test group at day 14. MANOVA result showed probiotic's effect in enhancing histological structure changes during gastric ulcer healing process. Better histological structure changes were observed in mucus thickness; reepitelization, gastric glands formation, and angiogenesis process of the test group. As a conclusion, probiotic enhanced mucus thickness, reepitelization, glands remodelling, and angiogenesis in Aspirin induced gastric ulcer healing process in animal model. Key words: probiotic, gastric ulcer, histological structure, aspirin, healing process
Synthesis and Biological Evaluation of New 3,4-diarylmaleimides as Enhancers (modulators) of Doxorubicin Cytotoxic Activity on Cultured Tumor Cells from a Real Case of Breast Cancer
Authors: Gutierrez-Cano Jessica R. , Nahide Pradip D. , Ramadoss Velayudham , Satkar Yuvraj , Ortiz-Alvarado Rafael , Alba-Betancourt Clara , Mendoza-Macías Claudia L. , Solorio-Alvarado César R. 
Published: January 2018

A series of new 3,4-diarylmaleimides were synthesized in an optimized and efficient lineal sequence of three steps, starting from commercial maleimide. The biological evaluation of these compounds as enhancers (activity modulators) in the co-administration with doxorubicin treatment in breast cancer cells directly obtained from a patient, were essayed. The cancerous tissue BT026-512N was provided by the National Institute of Cancerology (INCAN) of México. This tissue was obtained by biopsy from a patient diagnosed with stage IIB ductal breast cancer. The results obtained in the assays, show decreased cell viability on the cultured cells for all of the maleimides synthesized in combinatorial administration with doxorubicin. The highest mortality effect was determined for maleimides 9 and 29 increased in close to three times the effect compared with treatment using only doxorubicin. Based on previous functionalized maleimides core reports and Molinspiration chemoinformatic analysis, these results could possibly point out to the Pg-p glycoprotein as bio-molecular action target of maleimides by kinase phosphorylation-inhibition, although more experimental data is necessary.
Transformation of Ferulic Acid and Vanillin by Isolated Placentas of Capsicum chinense and Capsicum annuum
Authors: Vázquez-Flota Felipe , Monforte-González Miriam , Miranda-Ham María de Lourdes , Castro-Concha Lizbeth A. 
Published: January 2018

Isolated placentas of the highly pungent Capsicum chinense (Habanero pepper), readily transformed ferulic acid and vanillin into capsaicinoids, whereas those from a mild C. annuum cultivar showed a low transformation rate of ferulic acid, in comparison to vanillin. Cell cultures from both species showed low levels of capsaicinoids and exposure to both intermediaries did not increase their amounts. Results suggest that the transformation of ferulic acid to vanillin is a limiting step in capsaicinoids synthesis in C. annuum, but not in C. chinense and thus, may account for its higher pungency.
GPU Algorithm for the Scaled Opposite-Spin (SOS) MP2 Energy Evaluation
Authors: Martínez-Martínez Luis Ángel , Amador-Bedolla Carlos 
Published: January 2018

<p>The most computationally intensive part of the SOS-MP2 algorithm for the calculation of the correlation energy [1], as executed in Q-Chem, is implemented for use in a graphical processing unit (GPU). Our approach adds new routines to the library initially developed by Aspuru-Guzik and co-workers [2], aiming at maximization of bandwidth and performance, by taking advantage of the asynchronous CPU-GPU communication capability of modern GPUs. These changes permit an almost six-fold acceleration in the correlation energy calculation of linear alkanes. This was achieved employing a NVIDIA Tesla K40C (Kepler) GPU and the Compute Unified Device Architecture (CUDA).</p>
Tonantzitlolone A and other cytotoxic constituents of Sapium macrocarpum (Euphorbiaceae)
Authors: Novillo Fernando , Rosero Verónica , Chávez María Isabel , Hernández-Ortega Simón , Martínez Esteban M. , Delgado Guillermo 
Published: January 2018

Sapium macrocarpum (Euphorbiaceae) is a tropical tree located mainly in the southern part of Mexico and in Central America, and it is used in the Mayan traditional medicine for the treatment of several skin diseases. The dichloromethane-MeOH extract of the aerial parts displayed cytotoxic activity against certain cancer cell lines. Lupeol (1), lupenone (2), sitostenone (3), β-sitosterol (4), stigmasterol (5), sitosteryl β-D-glucopyranoside (6) and the rare diterpene tonantzitlolone A (7) were characterized from this extract. The structural analysis allowed the 1H NMR reassignments for H-12α and H-12β, and for H-13α and H-13β of tonantzitlolone A (7). The cytotoxic activity of compounds 1-3, 6 and 7 was evaluated against selected cancer cell lines. Compounds 3, 6 and 7 displayed clear activity against K562 (leukemia). This is the first report on the chemical constituents of S. macrocarpum, and points out that this species is an additional source of tonantzitlolone A. Compound 7 has only been reported previously from species of the Stillingia, Sebastiania and Sapium genera, which belong to the Hippomaninae subtribe of the family Euphorbiaceae.
Development of an item list to assess bilateral upper extremity function of stroke patients with hemiplegia
Authors: Lee Joo-Hyun , Park Ji-Hyuk 
Published: January 2018

BACKGROUND: Although there is a myriad of unilateral assessments for stroke survivors, few address bilateral function, which is critical for many daily living tasks. OBJECTIVE: To develop an activities of daily living list of tasks requiring bilateral upper extremity function for use when assessing patients with stroke. METHOD: A list of 938 items was generated based on a literature review, opinions of occupational therapists and patients with stroke. A panel of professional experts then validated that the items were bilateral and functional. Similar items were then combined and duplicates eliminated. RESULTS: The list was reduced to 69 items and 40 items were selected based on the content validity index. Based on the bilateral function, importance, expansion, and deletion criteria, the expert panel selected 27 items that best represented bilateral activities of daily living. CONCLUSIONS: A final list of 27 activities of daily living requiring bilateral function was generated and validated. Future work will focus on development of a tool to assess bilateral upper extremity function of patients with stroke.
Alternatives to the face-to-face consultation in general practice: focused ethnographic case study
Authors: Atherton Helen , Brant Heather , Ziebland Sue , Bikker Annemieke , Campbell John , Gibson Andy , McKinstry Brian , Porqueddu Tania , Salisbury Chris 
Published: January 2018

BackgroundNHS policy encourages general practices to introduce alternatives to the face-to-face consultation, such as telephone, email, e-consultation systems, or internet video. Most have been slow to adopt these, citing concerns about workload. This project builds on previous research by focusing on the experiences of patients and practitioners who have used one or more of these alternatives.AimTo understand how, under what conditions, for which patients, and in what ways, alternatives to face-to-face consultations present benefits and challenges to patients and practitioners in general practice.Design and settingFocused ethnographic case studies took place in eight UK general practices between June 2015 and March 2016.MethodNon-participant observation, informal conversations with staff, and semi-structured interviews with staff and patients were conducted. Practice documents and protocols were reviewed. Data were analysed through charting and the ‘one sheet of paper’ mind-map method to identify the line of argument in each thematic report.ResultsCase study practices had different rationales for offering alternatives to the face-to-face consultation. Beliefs varied about which patients and health issues were suitable. Co-workers were often unaware of each other’s practice; for example, practice policies for use of e-consultations systems with patients were not known about or followed. Patients reported benefits including convenience and access. Staff and some patients regarded the face-to-face consultation as the ideal.ConclusionExperience of implementing alternatives to the face-to-face consultation suggests that changes in patient access and staff workload may be both modest and gradual. Practices planning to implement them should consider carefully their reasons for doing so and involve the whole practice team.
Identifying Exoplanets with Deep Learning: A Five-planet Resonant Chain around Kepler-80 and an Eighth Planet around Kepler-90
Authors: Shallue Christopher J. , Vanderburg Andrew 
Published: January 2018

AbstractNASA’sKepler Space Telescopewas designed to determine the frequency of Earth-sized planets orbiting Sun-like stars, but these planets are on the very edge of the mission’s detection sensitivity. Accurately determining the occurrence rate of these planets will require automatically and accurately assessing the likelihood that individual candidates are indeed planets, even at low signal-to-noise ratios. We present a method for classifying potential planet signals using deep learning, a class of machine learning algorithms that have recently become state-of-the-art in a wide variety of tasks. We train a deep convolutional neural network to predict whether a given signal is a transiting exoplanet or a false positive caused by astrophysical or instrumental phenomena. Our model is highly effective at ranking individual candidates by the likelihood that they are indeed planets: 98.8% of the time it ranks plausible planet signals higher than false-positive signals in our test set. We apply our model to a new set of candidate signals that we identified in a search of knownKeplermulti-planet systems. We statistically validate two new planets that are identified with high confidence by our model. One of these planets is part of a five-planet resonant chain around Kepler-80, with an orbital period closely matching the prediction by three-body Laplace relations. The other planet orbits Kepler-90, a star that was previously known to host seven transiting planets. Our discovery of an eighth planet brings Kepler-90 into a tie with our Sun as the star known to host the most planets.
Characterizing TW Hydra
Authors: Sokal Kimberly R. , Deen Casey P. , Mace Gregory N. , Lee Jae-Joon , Oh Heeyoung , Kim Hwihyun , Kidder Benjamin T. , Jaffe Daniel T. 
Published: January 2018

Abstract
At 60 pc, TW Hydra (TW Hya) is the closest example of a star with a gas-rich protoplanetary disk, though TW Hya may be relatively old (3–15 Myr). As such, TW Hya is especially appealing for testing our understanding of the interplay between stellar and disk evolution. We present a high-resolution near-infrared spectrum of TW Hya obtained with the Immersion GRating INfrared Spectrometer (IGRINS) to re-evaluate the stellar parameters of TW Hya. We compare these data to synthetic spectra of magnetic stars produced by MoogStokes, and use sensitive spectral line profiles to probe the effective temperature, surface gravity, and magnetic field. A model with

K,

, and

kG best fits the near-infrared spectrum of TW Hya. These results correspond to a spectral type of M0.5 and an age of 8 Myr, which is well past the median life of gaseous disks.
Elucidating ΛCDM: Impact of Baryon Acoustic Oscillation Measurements on the Hubble Constant Discrepancy
Authors: Addison G. E. , Watts D. J. , Bennett C. L. , Halpern M. , Hinshaw G. , Weiland J. L. 
Published: January 2018

Abstract
We examine the impact of baryon acoustic oscillation (BAO) scale measurements on the discrepancy between the value of the Hubble constant (H
0) inferred from the local distance ladder and that from Planck cosmic microwave background (CMB) data. While the BAO data alone cannot constrain H
0, we show that combining the latest BAO results with WMAP, Atacama Cosmology Telescope (ACT), or South Pole Telescope (SPT) CMB data produces values of H
0 that are

lower than the distance ladder, independent of Planck, and that this downward pull was less apparent in some earlier analyses that used only angle-averaged BAO scale constraints rather than full anisotropic information. At the same time, the combination of BAO and CMB data also disfavors the lower values of H
0 preferred by the Planck high-multipole temperature power spectrum. Combining galaxy and Lyα forest BAO with a precise estimate of the primordial deuterium abundance produces

km s−1 Mpc−1 for the flat

model. This value is completely independent of CMB anisotropy constraints and is

lower than the latest distance ladder constraint, although

tension also exists between the galaxy BAO and Lyα BAO. These results show that it is not possible to explain the H
0 disagreement solely with a systematic error specific to the Planck data. The fact that tensions remain even after the removal of any single data set makes this intriguing puzzle all the more challenging to resolve.
Effect of Upstream ULF Waves on the Energetic Ion Diffusion at the Earth's Foreshock. I. Theory and Simulation
Authors: Otsuka Fumiko , Matsukiyo Shuichi , Kis Arpad , Nakanishi Kento , Hada Tohru 
Published: January 2018

Abstract
Field-aligned diffusion of energetic ions in the Earth’s foreshock is investigated by using the quasi-linear theory (QLT) and test particle simulation. Non-propagating MHD turbulence in the solar wind rest frame is assumed to be purely transverse with respect to the background field. We use a turbulence model based on a multi-power-law spectrum including an intense peak that corresponds to upstream ULF waves resonantly generated by the field-aligned beam (FAB). The presence of the ULF peak produces a concave shape of the diffusion coefficient when it is plotted versus the ion energy. The QLT including the effect of the ULF wave explains the simulation result well, when the energy density of the turbulent magnetic field is 1% of that of the background magnetic field and the power-law index of the wave spectrum is less than 2. The numerically obtained e-folding distances from 10 to 32 keV ions match with the observational values in the event discussed in the companion paper, which contains an intense ULF peak in the spectra generated by the FAB. Evolution of the power spectrum of the ULF waves when approaching the shock significantly affects the energy dependence of the e-folding distance.
Broadband Photometric Reverberation Mapping Analysis on SDSS-RM and Stripe 82 Quasars
Authors: Zhang Haowen , Yang Qian , Wu Xue-Bing 
Published: January 2018

Abstract
We modified the broadband photometric reverberation mapping (PRM) code, JAVELIN, and tested the availability to get broad-line region time delays that are consistent with the spectroscopic reverberation mapping (SRM) project SDSS-RM. The broadband light curves of SDSS-RM quasars produced by convolution with the system transmission curves were used in the test. We found that under similar sampling conditions (evenly and frequently sampled), the key factor determining whether the broadband PRM code can yield lags consistent with the SRM project is the flux ratio of the broad emission line to the reference continuum, which is in line with the previous findings. We further found a critical line-to-continuum flux ratio, about 6%, above which the mean of the ratios between the lags from PRM and SRM becomes closer to unity, and the scatter is pronouncedly reduced. We also tested our code on a subset of SDSS Stripe 82 quasars, and found that our program tends to give biased lag estimations due to the observation gaps when the R-L relation prior in Markov Chain Monte Carlo is discarded. The performance of the damped random walk (DRW) model and the power-law (PL) structure function model on broadband PRM were compared. We found that given both SDSS-RM-like or Stripe 82-like light curves, the DRW model performs better in carrying out broadband PRM than the PL model.
Evidence for Precession due to Supercritical Accretion in Ultraluminous X-Ray Sources
Authors: Weng Shan-Shan , Feng Hua 
Published: January 2018

Abstract
Most ultraluminous X-ray sources (ULXs) are thought to be supercritical accreting compact objects, where massive outflows are inevitable. Using the long-term monitoring data with the Swift X-ray Telescope, we identified a common feature in bright, hard ULXs: they display a quasi-periodic modulation in their hard X-ray band but not in their soft band. As a result, some sources show a bimodal distribution on the hardness intensity map. We argue that these model-independent results can be well interpreted in a picture that involves supercritical accretion with precession, where the hard X-ray emission from the central funnel is more or less beamed, while the soft X-rays may arise from the photosphere of the massive outflow and be nearly isotropic. It implies that precession may be ubiquitous in supercritical systems, such as the Galactic microquasar SS 433. How the hard X-rays are modulated can be used to constrain the angular distribution of the hard X-ray emission and the geometry of the accretion flow. We also find that two ULX pulsars (NGC 5907 ULX-1 and NGC 7793 P13) show similar behaviors but no bimodal distribution, which may imply that they have a different beaming shape or mechanism.
Empirical Temperature Measurement in Protoplanetary Disks
Authors: Weaver Erik , Isella Andrea , Boehler Yann 
Published: January 2018

Abstract
The accurate measurement of temperature in protoplanetary disks is critical to understanding many key features of disk evolution and planet formation, from disk chemistry and dynamics, to planetesimal formation. This paper explores the techniques available to determine temperatures from observations of single, optically thick molecular emission lines. Specific attention is given to issues such as the inclusion of optically thin emission, problems resulting from continuum subtraction, and complications of real observations. Effort is also made to detail the exact nature and morphology of the region emitting a given line. To properly study and quantify these effects, this paper considers a range of disk models, from simple pedagogical models to very detailed models including full radiative transfer. Finally, we show how the use of the wrong methods can lead to potentially severe misinterpretations of data, leading to incorrect measurements of disk temperature profiles. We show that the best way to estimate the temperature of emitting gas is to analyze the line peak emission map without subtracting continuum emission. Continuum subtraction, which is commonly applied to observations of line emission, systematically leads to underestimation of the gas temperature. We further show that once observational effects such as beam dilution and noise are accounted for, the line brightness temperature derived from the peak emission is reliably within 10%–15% of the physical temperature of the emitting region, assuming optically thick emission. The methodology described in this paper will be applied in future works to constrain the temperature, and related physical quantities, in protoplanetary disks observed with ALMA.
The Detection of Hot Cores and Complex Organic Molecules in the Large Magellanic Cloud
Authors: Sewiło Marta , Indebetouw Remy , Charnley Steven B. , Zahorecz Sarolta , Oliveira Joana M. , van Loon Jacco Th. , Ward Jacob L. , Chen C.-H. Rosie , Wiseman Jennifer , Fukui Yasuo , Kawamura Akiko , Meixner Margaret , Onishi Toshikazu , Schilke Peter 
Published: January 2018

Abstract
We report the first extragalactic detection of the complex organic molecules (COMs) dimethyl ether (CH3OCH3) and methyl formate (CH3OCHO) with the Atacama Large Millimeter/submillimeter Array (ALMA). These COMs, together with their parent species methanol (CH3OH), were detected toward two 1.3 mm continuum sources in the N 113 star-forming region in the low-metallicity Large Magellanic Cloud (LMC). Rotational temperatures (

K) and total column densities (

cm−2) have been calculated for each source based on multiple transitions of CH3OH. We present the ALMA molecular emission maps for COMs and measured abundances for all detected species. The physical and chemical properties of two sources with COMs detection, and the association with H2O and OH maser emission, indicate that they are hot cores. The fractional abundances of COMs scaled by a factor of 2.5 to account for the lower metallicity in the LMC are comparable to those found at the lower end of the range in Galactic hot cores. Our results have important implications for studies of organic chemistry at higher redshift.
Interroger la domination partisane : quand le parti hégémonique n’est pas le parti dirigeant
Authors: Fauconnier Clémentine 
Published: January 2018

Alors que le parti Russie unie, créé en 2001 pour soutenir Vladimir Poutine cette même année, domine le système partisan russe depuis quinze ans, son poids politique demeure paradoxalement faible. Il constitue ainsi un cas peu étudié dans la littérature sur les organisations partisanes : celui d’un parti hégémonique – au sens de Giovanni Sartori d’une organisation partisane qui évolue dans un système non compétitif – mais qui pourtant n’est pas un parti dirigeant et demeure un instrument entre les mains des dirigeants du pouvoir exécutif. Cet article vise à éclairer un des aspects de cette forme de domination partisane particulière en analysant les ressorts de ses victoires aux élections régionales puis législatives, dans un contexte de baisse du soutien de la part des électeurs. Il montre en effet de quelle façon, après le mouvement de protestation de l’hiver 2011-2012, les dirigeants de l’exécutif ont finalement choisi de maintenir le statu quo en garantissant la domination de Russie unie via une réforme de la législation électorale plutôt que de réformer le parti ou de renforcer son rôle dans la vie politique russe.