bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive Insular Sampling in Pediatric Epilepsy: A Single-Institution Experience
Authors: Tomycz Luke D , Hale Andrew T , Haider Ali S , Clarke Dave F , Lee Mark R 
Published: December 2017

Abstract

BACKGROUND
It has been increasingly recognized that the insular cortex plays an important role in frontotemporal-parietal epilepsy in children. The insula, however, cannot be properly interrogated with conventional subdural grids, and its anatomy makes it difficult to implicate the insula with semiology or noninvasive modalities. Frame-based, stereotactic placement of insular depth electrodes for direct extraoperative monitoring is a relatively low-risk maneuver that allows for conclusive interrogation of this region, and, in select cases, can easily be replaced with a laser applicator for minimally invasive treatment via thermoablation.

OBJECTIVE
To describe the largest reported series of pediatric patients with refractory epilepsy undergoing insular depth electrode placement.

METHODS
We used current procedural terminology billing records to identify cases of depth electrode insertion performed at our institution. Clinical information from patients undergoing invasive insular sampling was then retrospectively collected.

RESULTS
Seventy-four insular depth electrodes were placed in 49 patients for extraoperative, inpatient monitoring. The decision to place insular depth electrodes was determined by a multidisciplinary epilepsy team. In 65.3% of cases, direct invasive sampling implicated the insula in seizure onset and prompted either thermoablation or surgical resection of some portion of the insula. There were no serious adverse effects or complications associated with the placement of insular depth electrodes.

CONCLUSION
Given the low morbidity of insular depth electrode insertion and the high proportion of patients who exhibited insular involvement, it is worth considering whether insular depth electrodes should be part of the standard presurgical evaluation in children with treatment-refractory frontotemporal-parietal epilepsy.
Clozapine and Norclozapine Concentrations in Paired Human Plasma and Serum Samples
Authors: Handley Simon A. , Silk Stuart W. , Fisher Danielle S. , Subramaniam Krithika , Flanagan Robert J. 
Published: December 2017

Background:
Plasma and serum are often used interchangeably for therapeutic drug monitoring (TDM) purposes, and concentrations of some drugs are reported to be lower in serum than in plasma when collected into blood collection tubes containing a gel separator. TDM is recommended for clozapine, although few studies have compared concentrations between plasma and serum. Therefore, we investigated the comparability of dipotassium ethylenediaminetetraacetic acid human plasma and serum from blood collection tubes containing a gel separator for the measurement of clozapine and norclozapine.

Methods:
Whole blood from patients (N = 93) prescribed clozapine was collected into a polypropylene Vacuette dipotassium ethylenediaminetetraacetic acid–containing blood collection tube (Greiner Bio-One), and a polypropylene Vacuette serum separator blood collection tube (Greiner Bio-One) containing a clotting activator (silica particles) and a polymer gel.

Results:
Mean clozapine concentrations were significantly (P ≤ 0.05) lower in serum (0.37 mg/L) than in plasma (0.39 mg/L), as were concentrations of norclozapine (0.17 and 0.18 mg/L, respectively). Bland–Altman plots indicated mean serum clozapine and norclozapine were 0.018 mg/L (5.3%) and 0.004 mg/L (3.6%), respectively, lower in serum than plasma.

Conclusions:
Despite the finding that clozapine and norclozapine were significantly higher in plasma than in serum when obtained from blood collected into Vacuette serum separator collection tubes, this difference is insignificant in the clinical interpretation of clozapine and norclozapine TDM results.
Simulation Training Facilitates Physical Therapists' Self-efficacy in the Intensive Care Unit
Authors: Silberman Nicki J. , Mintz Sarah B. , Zych Natalie , Bloch Naomi , Tal Eric R. , Rios Lorena 
Published: December 2017

Purpose:
Physical therapists (PTs) perform early mobilization in the intensive care unit (ICU), but specialized knowledge, skills, and behaviors for ICU clinical practice pose unique challenges. High-fidelity human simulation (HFHS) training prepares medical professionals for ICU practice, but evidence on HFHS training for PTs is limited. The purpose was to develop and evaluate an HFHS-based training program focused on improving PTs' self-efficacy for ICU clinical practice.

Methods:
Six PTs participated in 3 immersive HFHS experiences, each including a simulation and group debriefing. All participants completed self-efficacy surveys pre- and posttraining. A focus group was conducted to gather participant perspectives on the learning experience.

Results:
Significant improvements in 3 self-efficacy categories occurred: performing a chart review, understanding precautions/medications, and implementing early mobilization. Qualitative analysis of the focus group revealed 4 themes: simulation facilitates positive reinforcement and confidence building; collaborative learning in a safe environment promotes skill acquisition, teamwork in training improves clinical collaboration; and simulation provides effective orientation to complex line management. The small sample size and unknown psychometric properties of the self-efficacy scale limit these results.

Conclusions:
The HFHS program facilitated PTs' teamwork, collaboration, and self-efficacy for ICU clinical practice. Further investigation is recommended to evaluate the efficacy of HFHS as a training tool to enhance PT practice in the ICU.
Transition from fractional to classical Stokes–Einstein behaviour in simple fluids
Authors: Coglitore Diego , Edwardson Stuart P. , Macko Peter , Patterson Eann A. , Whelan Maurice 
Published: December 2017

An optical technique for tracking single particles has been used to evaluate the particle diameter at which diffusion transitions from molecular behaviour described by the fractional Stokes–Einstein relationship to particle behaviour described by the classical Stokes–Einstein relationship. The results confirm a prior prediction from molecular dynamic simulations that there is a particle size at which transition occurs and show it is inversely dependent on concentration and viscosity but independent of particle density. For concentrations in the range 5 × 10
−3
to 5 × 10
−6
mg ml
−1
and viscosities from 0.8 to 150 mPa s, the transition was found to occur in the diameter range 150–300 nm.
Adsorption and photocatalysis for methyl orange and Cd removal from wastewater using TiO
2
/sewage sludge-based activated carbon nanocomposites
Authors: Rashed M. Nageeb , Eltaher M. A. , Abdou A. N. A. 
Published: December 2017

Nanocomposite TiO
2
/ASS (TiO
2
nanoparticle coated sewage sludge-based activated carbon) was synthesized by the sol-gel method. The changes in surface properties of the TiO
2
/ASS nanocomposite were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and X-ray fluorescence. The prepared TiO
2
/ASS nanocomposite was applied for simultaneous removal of methyl orange dye (MO) and Cd
2+
from bi-pollutant solution. The factors influencing photocatalysis (TiO
2
: ASS ratios, initial pollutant concentrations, solution pH, nanocomposite dosage and UV irradiation time) were investigated. The results revealed that high removal efficiency of methyl orange dye (MO) and Cd
2+
from bi-pollutant solution was achieved with TiO
2
/ASS at a ratio (1 : 2). The obtained results revealed that degradation of MO dye on the TiO
2
/ASS nanocomposite was facilitated by surface adsorption and photocatalytic processes. The coupled photocatalysis and adsorption shown by TiO
2
/ASS nanocomposite resulted in faster and higher degradation of MO as compared to MO removal by ASS adsorbent. The removal efficiency of MO by ASS adsorbent and TiO
2
/ASS (1 : 2) nanocomposite at optimum pH value 7 were 74.14 and 94.28%, respectively, while for Cd
2+
it was more than 90%. The experimental results fitted well with the second-order kinetic reaction.
incR: a new R package to analyse incubation behaviour
Authors: Capilla-Lasheras Pablo 
Published: December 2017

AbstractIncubation represents a life stage of crucial importance for the optimal development of avian embryos. For most birds, incubation poses a trade-off between investing in self-maintenance and offspring care. Furthermore, incubation is affected by environmental temperatures and, therefore, will be likely impacted by climate change. Despite its relevance and readily available temperature logging methods, avian incubation research is hindered by recognised limitations in available software. In this paper, a new quantitative approach to analyse incubation behaviour is presented. This new approach is embedded in a free R package, incR. The flexibility of the R environment eases the analysis, validation and visualisation of incubation temperature data. The core algorithm in incR is validated here and it is shown that the method extracts accurate metrics of incubation behaviour (e.g. number and duration of incubation bouts). This paper also presents a suggested workflow along with detailed R code to aid the practical implementation of incR.
Genetic and cellular sensitivity ofCaenorhabditis elegansto the chemotherapeutic agent cisplatin
Authors: García-Rodríguez Francisco Javier , Martínez-Fernández Carmen , Brena David , Nadal Ernest , Boxem Mike , Honnen Sebastian , Miranda-Vizuete Antonio , Villanueva Alberto , Cerón Julián 
Published: December 2017

ABSTRACTCisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties: (i) the onset of resistance to the drug, and (ii) the cytotoxic effect in patients. Here we useCaenorhabditis elegansto investigate factors influencing the response to cisplatin in multicellular organisms. In this hermaphroditic model organism, we observed that sperm failure is a major cause in cisplatin-induced infertility. RNA-seq data indicate that cisplatin triggers a systemic stress response in which DAF-16/FOXO and SKN-1/Nrf2, two conserved transcription factors, are key regulators. We determined that inhibition of the DNA-damage induced apoptotic pathway does not confer cisplatin protection to the animal. However, mutants for the pro-apoptotic BH3-only geneced-13are sensitive to cisplatin, suggesting a protective role of the intrinsic apoptotic pathway. Finally, we demonstrate that our system can also be used to identify mutations providing resistance to cisplatin and therefore potential biomarkers of innate cisplatin-refractory patients. We show that mutants for the redox regulatortrxr-1, ortholog of the mammalian Thioredoxin-Reductase-1 TrxR1, display cisplatin resistance and that such resistance relies on a single selenocysteine residue.
Outbreak of invasive wound mucormycosis in a burn unit due to multiple strains of Mucor circinelloides f. circinelloides resolved by whole genome sequencing
Authors: Garcia-Hermoso Dea , Criscuolo Alexis , Lee Soo chan , Legrand Matthieu , Chaouat Marc , Denis Blandine , Lafaurie Matthieu , Rouveau Martine , Soler Charles , Schaal Jean-Vivien , Mimoun Maurice , Mebazaa Alexandre , Heitman Joseph , Dromer Françoise , Brisse Sylvain , Bretagne Stéphane , Alanio Alexandre 
Published: December 2017

AbstractMucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole genome sequencing (WGS) analysis.We analyzed M. circinelloides isolates from patients in our burn unit (BU1) together with non-outbreak isolates from burn unit 2 (BU2, Paris area) and from France over a two-year period (2013-2015). For each isolate, WGS and a de novo genome assembly was performed from read data extracted from the aligned contig sequences of the reference genome (1006PhL).A total of 21 isolates were sequenced including 14 isolates from six BU1 patients. Phylogenetic classification showed that the clinical isolates clustered in four highly divergent clades. Clade1 contained at least one of the strains from the six epidemiologically-linked BU1 patients. The clinical isolates seemed specific to each patient. Two patients were infected with more than two strains from different clades suggesting that an environmental reservoir of clonally unrelated isolates was the source of contamination. Only two patients shared one strain in BU1, suggesting direct transmission or contamination with the same environmental source.WGS coupled with precise epidemiological data and analysis of several isolates per patients revealed in our study a complex situation with both potential cross-transmission and multiple contaminations with a heterogeneous pool of strains from a cryptic environmental reservoir.ImportanceInvasive wound mucormycosis (IWM) is a severe infection due to the environmental molds belonging to the order Mucorales. Severely burned patients are particularly at risk for IWM. Here, we used Whole Genome Sequencing (WGS) analysis to resolve an outbreak of IWM due to Mucor circinelloides that occurred in our hospital (BU1). We sequenced 21 clinical isolates, including 14 from BU1 and 7 unrelated isolates, and compared them to the reference genome (1006PhL). This analysis revealed that the outbreak was mainly due to multiple strains that seemed patient-specific, suggesting that the patients were more likely infected from a pool of diverse strains from the environment rather than from direct transmission between the patients. This study revealed the complexity of a Mucorales outbreak in the settings of IWM in burn patients, which has been highlighted based on whole genome sequencing and careful sampling.
P-like controllers with collision avoidance for passive bilateral teleoperation of a UAV
Authors: Sun Huiyu , Song Guangming , Wei Zhong , Zhang Ying 
Published: December 2017

Purpose
This paper aims to tele-operate the movement of an unmanned aerial vehicle (UAV) in the obstructed environment with asymmetric time-varying delays. A simple passive proportional velocity errors plus damping injection (P-like) controller is proposed to deal with the asymmetric time-varying delays in the aerial teleoperation system.

Design/methodology/approach
This paper presents both theoretical and real-time experimental results of the bilateral teleoperation system of a UAV for collision avoidance over the wireless network. First, a position-velocity workspace mapping is used to solve the master-slave kinematic/dynamic dissimilarity. Second, a P-like controller is proposed to ensure the stability of the time-delayed bilateral teleoperation system with asymmetric time-varying delays. The stability is analyzed by the Lyapunov–Krasovskii function and the delay-dependent stability criteria are obtained under linear-matrix-inequalities conditions. Third, a vision-based localization is presented to calibrate the UAV’s pose and provide the relative distance for obstacle avoidance with a high accuracy. Finally, the performance of the teleoperation scheme is evaluated by both human-in-the-loop simulations and real-time experiments where a single UAV flies through the obstructed environment.

Findings
Experimental results demonstrate that the teleoperation system can maintain passivity and collision avoidance can be achieved with a high accuracy for asymmetric time-varying delays. Moreover, the operator could tele-sense the force reflection to improve the maneuverability in the aerial teleoperation.

Originality/value
A real-time bilateral teleoperation system of a UAV for collision avoidance is performed in the laboratory. A force and visual interface is designed to provide force and visual feedback of the slave environment to the operator.
Fuzzy logic PD controller for trajectory tracking of an autonomous differential drive mobile robot (i.e. Quanser Qbot)
Authors: Alouache Ali , Wu Qinghe 
Published: December 2017

Purpose
The aim of this paper is to propose a robust robot fuzzy logic proportional-derivative (PD) controller for trajectory tracking of autonomous nonholonomic differential drive wheeled mobile robot (WMR) of the type Quanser Qbot.

Design/methodology/approach
Fuzzy robot control approach is used for developing a robust fuzzy PD controller for trajectory tracking of a nonholonomic differential drive WMR. The linear/angular velocity of the differential drive mobile robot are formulated such that the tracking errors between the robot’s trajectory and the reference path converge asymptotically to zero. Here, a new controller zero-order Takagy–Sugeno trajectory tracking (ZTS-TT) controller is deduced for robot’s speed regulation based on the fuzzy PD controller. The WMR used for the experimental implementation is Quanser Qbot which has two differential drive wheels; therefore, the right/left wheel velocity of the differential wheels of the robot are worked out using inverse kinematics model. The controller is implemented using MATLAB Simulink with QUARC framework, downloaded and compiled into executable (.exe) on the robot based on the WIFI TCP/IP connection.

Findings
Compared to other fuzzy proportional-integral-derivative (PID) controllers, the proposed fuzzy PD controller was found to be robust, stable and consuming less resources on the robot. The comparative results of the proposed ZTS-TT controller and the conventional PD controller demonstrated clearly that the proposed ZTS-TT controller provides better tracking performances, flexibility, robustness and stability for the WMR.

Practical implications
The proposed fuzzy PD controller can be improved using hybrid techniques. The proposed approach can be developed for obstacle detection and collision avoidance in combination with trajectory tracking for use in environments with obstacles.

Originality/value
A robust fuzzy logic PD is developed and its performances are compared to the existing fuzzy PID controller. A ZTS-TT controller is deduced for trajectory tracking of an autonomous nonholonomic differential drive mobile robot (i.e. Quanser Qbot).
POLIBOT – POwer Lines Inspection RoBOT
Authors: Lima Eduardo José , Bomfim Marcelo Henrique Souza , Mourão Miguel Augusto de Miranda 
Published: December 2017

Purpose
Several studies have aimed to develop robotic systems which move in transmission lines. Until this moment, all of them have a high weight and cost associated with the equipment and reduced battery autonomy time. In this context, this paper aims to propose the POLIBOT (POwer Lines Inspection roBOT) with low cost and weight, enabling the movement over the lines and an easier installation and remove.

Design/methodology/approach
The designed robot uses the Profiles Manufacturing Methodology (PMM). The construction of the robot mechanical structure uses modularized aluminum parts built through square profiles. Thus, it’s possible a drastic reduction in production time as well as cost reduction and weight when comparing this method with other manufacturing processes like foundry, for example. For hardware and software systems, the use of free and open source software causes a significant reduction in cost and project execution time. The benefits of using open source systems are immeasurable, both from academic and industrial applications.

Findings
The POLIBOT platform is one solution to the problem of inspection in power lines. With this robot, more lines are maintained with lower time. In its constructive aspect, the robotic mechanism is designed using principles of bioengineering. The use of this principle was successful, considering that obstacle transposition is performed with stability and low energy consumption.

Research limitations/implications
The suggestion for future researches is to replace the battery for solar energy and construction in polymeric material to avoid high magnetic fields.

Practical implications
The commercial application is evident because manual inspections are inefficient, very expensive and dangerous. Thus, it is growing the number of researches that develop mechatronics systems for this kind of inspection.

Social implications
The impact is the reduction of accidents because the present procedure requires precision of movements, where the pilot and electrical technician are close to high electrical and magnetic fields. In addition, for some tasks, the worker has to walk on the line to reach some important points. Thus, those tasks involve high risk of death.

Originality/value
The PMM methodology represents an innovation to the state of the art because others robotic mechanisms proposed for inspection tasks present total structure mass between 50 and 100 kg and POLIBOT has only 9 kg. Other fact is its price for implementation as this robot used the robot operating system (ROS) framework, what dispense the use of licenses. Other important features are that the robot performs the tasks autonomously, which reduces errors introduced by the operator and its low manufacturing cost as compared with other projects.
Influencing consumer boycott: between sympathy and pragmatic
Authors: Ishak Suraiya , Khalid Kartini , Sulaiman Nidzam 
Published: December 2017

Purpose
This paper aims to examine consumers’ responses to products that are influenced by their moral justification. Specifically, this paper examines the factors related to consumers’ moral response and choices, including religious affiliation and obligation, group memberships, group reference, type of product and link of egregious conduct to particular products. This study explicates Adam Smith’s concept of people’s proprietary emotion that potentially affects their purchasing behavior.

Design/methodology/approach
This study uses focus group discussion with nine consumers across ethnic groups in Malaysia. A recent boycott case was used to stimulate the group discussion. Their statements are displayed in the findings to show their expressions verbatim.

Findings
The findings outline that consumers’ participation in the boycott of products is influenced by their moral judgment with frequent addressing of the religious affiliation and obligation, group reference and group membership factors. Additionally, there is a tendency that certain issue(s), although perceived as a universal humanistic issue, would be relatively closer to people with backgrounds similar to the majority of the victims of a particular issue. However, such a boycott action has issues such as duration of action, consistency of action and choice of pragmatic over moral decision that weigh the efficacy of the boycott action toward products related to certain egregious actions. Overall, the non-participation decision had been attached to factors such as type of product, boycotting cost, brand attraction and function or usefulness of products. These factors may also moderate consumers’ sentiment to boycott a particular product(s) in the long term.

Originality/value
This paper offers new insight regarding factors influencing participation in the boycott of products which were suspected to have link with egregious conduct towards certain Muslim groups. This paper offers a different perspective by integrating ethical theory into the discussion. In addition, it explores the influence of Muslims’ brotherhood concept on participation in boycott activities.