bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of Resistive Switching Behavior in Crossbar Core–Shell Ni/NiO Nanowires Memristor
Authors: Ting Yi‐Hsin , Chen Jui‐Yuan , Huang Chun‐Wei , Huang Ting‐Kai , Hsieh Cheng‐Yu , Wu Wen‐Wei 
Published: December 2017

AbstractThe crossbar structure of resistive random access memory (RRAM) is the most promising technology for the development of ultrahigh‐density devices for future nonvolatile memory. However, only a few studies have focused on the switching phenomenon of crossbar RRAM in detail. The main purpose of this study is to understand the formation and disruption of the conductive filament occurring at the crossbar center by real‐time transmission electron microscope observation. Core–shell Ni/NiO nanowires are utilized to form a cross‐structure, which restrict the position of the conductive filament to the crosscenter. A significant morphological change can be observed near the crossbar center, which results from the out‐diffusion and backfill of oxygen ions. Energy dispersive spectroscopy and electron energy loss spectroscopy demonstrate that the movement of the oxygen ions leads to the evolution of the conductive filament, followed by redox reactions. Moreover, the distinct reliability of the crossbar device is measured via ex situ experiments. In this work, the switching mechanism of the crossbar core–shell nanowire structure is beneficial to overcome the problem of nanoscale minimization. The experimental method shows high potential to fabricate high‐density RRAM devices, which can be applied to 3D stacked package technology and neuromorphic computing systems.
High‐Throughput Block Optical DNA Sequence Identification
Authors: Sagar Dodderi Manjunatha , Korshoj Lee Erik , Hanson Katrina Bethany , Chowdhury Partha Pratim , Otoupal Peter Britton , Chatterjee Anushree , Nagpal Prashant 
Published: December 2017

AbstractOptical techniques for molecular diagnostics or DNA sequencing generally rely on small molecule fluorescent labels, which utilize light with a wavelength of several hundred nanometers for detection. Developing a label‐free optical DNA sequencing technique will require nanoscale focusing of light, a high‐throughput and multiplexed identification method, and a data compression technique to rapidly identify sequences and analyze genomic heterogeneity for big datasets. Such a method should identify characteristic molecular vibrations using optical spectroscopy, especially in the “fingerprinting region” from ≈400–1400 cm−1. Here, surface‐enhanced Raman spectroscopy is used to demonstrate label‐free identification of DNA nucleobases with multiplexed 3D plasmonic nanofocusing. While nanometer‐scale mode volumes prevent identification of single nucleobases within a DNA sequence, the block optical technique can identify A, T, G, and C content in DNA k‐mers. The content of each nucleotide in a DNA block can be a unique and high‐throughput method for identifying sequences, genes, and other biomarkers as an alternative to single‐letter sequencing. Additionally, coupling two complementary vibrational spectroscopy techniques (infrared and Raman) can improve block characterization. These results pave the way for developing a novel, high‐throughput block optical sequencing method with lossy genomic data compression using k‐mer identification from multiplexed optical data acquisition.
Context‐dependent reconfiguration of autonomous vehicles in mixed traffic
Authors: Horcas José Miguel , Monteil Julien , Bouroche Mélanie , Pinto Mónica , Fuentes Lidia , Clarke Siobhán 
Published: December 2017

AbstractHuman drivers naturally adapt their behaviour depending on the traffic conditions, such as the current weather and road type. Autonomous vehicles need to do the same, in a way that is both safe and efficient in traffic composed of both conventional and autonomous vehicles. In this paper, we demonstrate the applicability of a reconfigurable vehicle controller agent for autonomous vehicles that adapts the parameters of a used car‐following model at runtime, so as to maintain a high degree of traffic quality (efficiency and safety) under different weather conditions. We follow a dynamic software product line approach to model the variability of the car‐following model parameters, context changes and traffic quality, and generate specific configurations for each particular context. Under realistic conditions, autonomous vehicles have only a very local knowledge of other vehicles' variables. We investigate a distributed model predictive controller agent for autonomous vehicles to estimate their behavioural parameters at runtime, based on their available knowledge of the system. We show that autonomous vehicles with the proposed reconfigurable controller agent lead to behaviour similar to that achieved by human drivers, depending on the context.
The Exploitation of Enzymatically‐Derived cis‐1,2‐Dihydrocatechols and Related Compounds in the Synthesis of Biologically Active Natural Products
Authors: Taher Ehab S. , Banwell Martin G. , Buckler Joshua N. , Yan Qiao , Lan Ping 
Published: December 2017

AbstractThe title compounds of the general form 1 can be produced at large scale and in essentially enantiomerically pure form (when X≠H) through the whole cell biotransformation of the corresponding aromatic. The “dense” and varied functionality associated with these metabolites mean that they have become increasingly useful chirons for the total synthesis of a range of natural product types. This personal account details the outcomes of a nearly three‐decade long campaign within our group to exploit these compounds in the synthesis of a diverse range of small molecule natural product targets. The work is subdivided according to the key transformation(s) employed in each synthesis. The development of newer chirons that “complement” the utility of the cis‐1,2‐dihydrocatechols are also described.
Serum relaxin and cervical length for prediction of spontaneous preterm birth in second‐trimester symptomatic women
Authors: Pantelis A. , Sotiriadis A. , Chatzistamatiou K. , Pratilas G. , Dinas K. 
Published: December 2017

ABSTRACTObjectiveTo investigate whether serum relaxin level is associated with preterm birth in symptomatic women, either as a standalone test or in the context of a combined model of serum relaxin and cervical length (CL).MethodsThis was a case–control study of women with a singleton pregnancy who presented between 24 + 0 and 26 + 6 weeks' gestation with threatened preterm labor and intact membranes. CL, full blood count, C‐reactive protein level and maternal demographics were recorded at presentation, and blood samples were taken for relaxin measurement. Parameters were compared between women who delivered preterm (before 37 weeks) (n = 46) and those delivering at term (n = 66). Logistic regression with receiver–operating characteristics (ROC) curve analysis was used to assess significant predictors for birth before 37 and before 34 weeks.ResultsWomen delivering before 37 weeks had higher mean serum relaxin levels and lower mean CL than those delivering at term (P < 0.0001). Relaxin alone had 63% (95% CI, 49–75%) sensitivity for birth before 37 weeks and 61% (95% CI, 47–74%) for birth before 34 weeks, at a 10% false‐positive rate (FPR). Serum relaxin levels did not correlate with CL; a combined model of the two predictors had an area under the ROC curve of 0.895 (95%CI, 0.835–0.954) for the prediction of birth before 37 weeks and 0.869 (95% CI, 0.802–0.937) for birth before 34 weeks (n =  44). Serum relaxin > 1010 pg/mL had 58% sensitivity for prediction of preterm birth in women with a CL > 15 mm, at a 10% FPR.ConclusionsHigh serum relaxin level is associated with an increased risk of preterm birth in second‐trimester symptomatic women with intact membranes. A combination of serum relaxin and CL increases predictive accuracy for preterm birth. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Increase of prostaglandin E2 in the reversal of fetal ductal constriction after polyphenol restriction
Authors: Vian I. , Zielinsky P. , Zílio A. M. , Schaun M. I. , Brum C. , Lampert K. V. , De Ávila N. , Baldissera G. , Klanovicz T. M. , Zenki K. , Zurita‐Peralta J. , Olszewski A. , Piccoli A. , Nicoloso L. H. , Sulis N. , Van Der Sand L. , Markoski M. 
Published: December 2017

ABSTRACTObjectiveAnti‐inflammatory substances that inhibit the synthesis of prostaglandins, such as non‐steroidal anti‐inflammatory drugs (NSAIDs) and polyphenol‐rich foods, can cause constriction of the fetal ductus arteriosus. This study aimed to test the hypothesis that reversal of fetal ductal constriction after maternal restriction of polyphenol‐rich foods, in the third trimester of pregnancy, is accompanied by increased plasma levels of prostaglandin E2 (PGE2).MethodsThis was a controlled clinical trial of women with singleton pregnancy ≥ 28 weeks undergoing fetal echocardiography. The intervention group included pregnancies with diagnosis of fetal ductal constriction and not exposed to NSAIDs. The control group consisted of third‐trimester normal pregnancies. Both groups answered a food frequency questionnaire to assess the amount of total polyphenols in their diet, underwent Doppler echocardiographic examination and had blood samples collected for analysis of plasma levels of PGE2. Intervention group participants received dietary guidance to restrict the intake of polyphenol‐rich foods. The assessments were repeated after 2 weeks in both groups.ResultsForty normal pregnancies were assessed in the control group and 35 with fetal ductal constriction in the intervention group. Mean maternal age (26.6 years) and mean body mass index (30.12 kg/m2) were similar between the two groups. Intragroup analysis showed that dietary guidance reduced the median consumption of polyphenols (from 1234.82 to 21.03 mg/day, P < 0.001), increasing significantly the plasma concentration of PGE2 (from 1091.80 to 1136.98 pg/mL, P < 0.05) in the intervention group after 2  weeks. In addition, Doppler echocardiography showed reversal of fetal ductal constriction in the intervention group. No significant changes were observed in the control group.ConclusionsDietary intervention for maternal restriction of polyphenol‐rich foods in the third trimester of pregnancy is accompanied by increase in plasma levels of PGE2 and reversal of fetal ductal constriction. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Resetting scheme for plastic strain surface in constitutive modeling of cyclic plasticity
Authors: Ohno Nobutada , Yamamoto Ryohei , Sasaki Tatsuya , Okumura Dai 
Published: December 2017

AbstractA resetting scheme is proposed for correctly evaluating the plastic strain range to analyze structural components subjected to regular cyclic loading following pre‐loading. In this scheme, a plastic strain surface, referred to as the plastic‐strain‐range surface in the present paper, is reset to a point and re‐evolves every cycle, with its size at the end of the last cycle considered to be the plastic strain range of the current cycle. This resetting scheme provides a definite value for the evolution parameter of the plastic‐strain‐range surface irrespective of the amounts of cyclic hardening, pre‐straining, and ratcheting. The resetting scheme is implemented in a cyclic viscoplastic model in finite element methods, and is applied to analyze a notched bar subjected to cyclic loading at its ends. Furthermore, the validity of the resetting scheme for non‐proportional cyclic loading is examined by analyzing the cyclic behavior along elliptic and rhombic strain paths. It is shown that the resetting scheme allows the use of a definite value for the evolution parameter of the plastic‐strain‐range surface in the presence of any cyclic hardening and/or ratcheting. Moreover, it is shown that the resetting scheme can be valid for cyclic loading with a certain degree of non‐proportionality.
Introduction: War and Memory in Russia, Ukraine, and Belarus
Authors: Fedor Julie , Lewis Simon , Zhurzhenko Tatiana 
Published: December 2017

Abstract
This introductory essay begins with a discussion of World War II memory in Russia, Ukraine, and Belarus, in light of the recent and ongoing war in Ukraine. It outlines the main contours of the interplay between “memory wars” and real war, and the important “post-Crimean” qualitative shift in local memory cultures in this connection. Next, the essay sketches out the specifics of the war memory landscapes of the region, and then of each of the three individual countries, before moving on to introduce the key organizing themes and findings of the book.
The “Partisan Republic”: Colonial Myths and Memory Wars in Belarus
Authors: Lewis Simon 
Published: December 2017

AbstractThis chapter combines trauma theory and postcolonial theory in the study of memory in post-war and post-Soviet Belarus. It argues that the Soviet myth of Belarus as the “Partisan Republic” displaced trauma, attempting to delimit the contours of memory but only deferring the painful process of coming to terms with the past. In addition, it examines the creation of a monolithic image of Soviet Belarusianness based on the memory of the war, i.e. the construct of the “Partisan Republic,” as a form of colonial discourse a means of imposing hegemonic identity norms on a dominated population. Both the Soviet-era resistance to this myth and the unmaking of the edifice in the post-Soviet era are analyzed in terms of postcolonial theory through discussion of the works of several Soviet and post-Soviet authors, musicians, and artists.
Plasma lipidomics as a diagnostic tool for peroxisomal disorders
Authors: Herzog Katharina , Pras‐Raves Mia L. , Ferdinandusse Sacha , Vervaart Martin A. T. , Luyf Angela C. M. , van Kampen Antoine H. C. , Wanders Ronald J. A. , Waterham Hans R. , Vaz Frédéric M. 
Published: December 2017

AbstractPeroxisomes are ubiquitous cell organelles that play an important role in lipid metabolism. Accordingly, peroxisomal disorders, including the peroxisome biogenesis disorders and peroxisomal single‐enzyme deficiencies, are associated with aberrant lipid metabolism. Lipidomics is an emerging tool for diagnosis, disease‐monitoring, identifying lipid biomarkers, and studying the underlying pathophysiology in disorders of lipid metabolism. In this study, we demonstrate the potential of lipidomics for the diagnosis of peroxisomal disorders using plasma samples from patients with different types of peroxisomal disorders. We show that the changes in the plasma profiles of phospholipids, di‐ and triglycerides, and cholesterol esters correspond with the characteristic metabolite abnormalities that are currently used in the metabolic screening for peroxisomal disorders. The lipidomics approach, however, gives a much more detailed overview of the metabolic changes that occur in the lipidome. Furthermore, we identified novel unique lipid species for specific peroxisomal diseases that are candidate biomarkers. The results presented in this paper show the power of lipidomics approaches to enable the specific diagnosis of different peroxisomal disorders.
Development and Evaluation of a Telephone Communication Protocol for the Delivery of Personalized Melanoma Genomic Risk to the General Population
Authors: Fenton Georgina L. , Smit Amelia K. , Freeman Lucinda , Badcock Caro , Dunlop Kate , Butow Phyllis N. , Kirk Judy , Cust Anne E. 
Published: December 2017

AbstractCommunicating personalized genomic risk results for common diseases to the general population as a form of tailored prevention is novel and may require alternative genetic counseling service delivery models. We describe the development and evaluation of a communication protocol for disclosing melanoma genomic risk information to the asymptomatic general population and assess participants’ satisfaction and acceptability. Participants (n = 117) were aged 22–69 years, living in New South Wales, Australia and unselected for family history. They provided a saliva sample and had genomic testing for melanoma for low to moderate penetrant melanoma susceptibility variants in 21 genes. Participants could choose to receive their results from a genetic counselor via telephone, followed by a mailed booklet or to receive their risk result via mailed booklet only with a follow‐up call for those at high risk. A follow‐up questionnaire was completed by 85% of participants 3‐months later. Most participants (80%) elected to receive their result via telephone. Participants were highly satisfied with the delivery of results (mean 3.4 out of 4, standard deviation 0.5), and this did not differ by delivery mode, risk category, age or sex. On follow‐up, 75% accurately recalled their risk category, 6% indicated a preference for a different delivery mode, either electronic or face‐to‐face. The process of disclosing genomic risk results to the general population over the telephone with accompanying written material was feasible and acceptable, and may be useful for communicating polygenic risk for common diseases in the context of increasing demands for genomic testing.
A National Referral Laboratory’s Experience with the Implementation of SNP-Based Non-invasive Prenatal Screening for Fetal Aneuploidy and Select Microdeletion Syndromes
Authors: Santamaria Raul , Bermejo Blanca , Cigarrán Sergio , Benn Peter 
Published: December 2017

AbstractTo retrospectively evaluate the successful test rate and performance of non-invasive prenatal screening (NIPS) for aneuploidies and microdeletions with international transportation of samples. Blood samples from Iberian women with singleton pregnancies were sent to a US laboratory for NIPS for aneuploidy and microdeletion syndromes (22q11.2, 1p36, Cri-du-chat, Prader Willi and Angelman). The NIPS methodology involved the analysis of single nucleotide polymorphisms in cell-free DNA in maternal plasma. Women with high-risk results were offered karyotyping and/or microarray confirmatory studies. Based on 14,175 women with successful testing (98.76% of all referrals), the overall test positive rate was 2.37% (1.9% for aneuploidy and 0.47% for microdeletion syndromes). Based on cases with known outcome, the positive predictive values (PPVs) were: for trisomy 21, 98.6%; trisomy 18, 85.7%; trisomy 13, 71.4%; monosomy-X, 87.5%; other sex chromosome aneuploidies, 100%; 22q11.2 deletion, 15.4%; and other microdeletions combined, 20%. With a protocol change that involved selective use of resequencing at a higher depth of read, the PPV for 22q11.2 deletion increased to 33.3 and 75% for the other microdeletions. Effective NIPS for both aneuploidies and select microdeletion syndromes can be provided even when this involves international transportation of blood specimens.
Work Motivation among Occupational Therapy Graduates in Malaysia
Authors: Chai Siaw Chui , Teoh Rui Fen , Razaob Nor Afifi , Kadar Masne 
Published: December 2017

Objective/Background Occupational therapy that focuses on servicing clients demands motivated workers for quality service delivery. The objectives of this study were: (a) to determine the level of work motivation among occupational therapy graduates in Malaysia and (b) to determine if there is a difference in work motivation among these graduates based on work sector, job position, length of work experience, and gender. Methods This cross-sectional study recruited occupational therapy bachelor's degree graduates using an online survey. The Work Extrinsic and Intrinsic Motivation Scale (WEIMS) was used to measure level of work motivation. Results Responses from 82 (60.3%) graduates (male: 26.8%; female: 73.2%) were analysed. Sixty-two (75.6%) graduates worked locally and 20 (24.4%) worked in foreign countries. The average Work Self-Determination Index (W-SDI) score for WEIMS is +11.38 with 78 (95.1%) of graduates demonstrated a self-determined motivational profile and 4 (4.9%) demonstrated a nonself-determined profile. Graduates in the private sector (13.10 ± 6.47) show significantly higher W-SDI score compared to those in the public sector (9.40 ± 6.06), p = 0.01. W-SDI scores appeared higher among clinician (11.67 ± 6.40), case manager (13.33), and others (14.90 ± 8.23); and those with work experience of 5–6 years (13.11 ± 6.90) and less than one year (12.65 ± 7.12). Male (10.29 ± 6.86) and female (11.79 ± 6.39) graduates shared equally high score. There is no significant difference in W-SDI score based on job position, length of work experience, and gender. Conclusion Occupational therapy graduates have high work motivation as evident by their self-determined profile. Only work sector imposes difference in work motivation among these graduates. Copyright © 2017, Hong Kong Occupational Therapy Association. Published by Elsevier (Singapore) Pte Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ).
Partnering With Patients Undergoing Hemodialysis to Prevent Catheter-Associated Bloodstream Infections
Authors: Mariano Victor D. , Castro-Sánchez Enrique 
Published: December 2017

Abstract
The threat of catheter-associated bloodstream infections (CABSIs) among hemodialysis patients is present beyond health care settings. With the rise of antimicrobial-resistant infections, the benefits of partnering with patients in preventing CABSIs cannot be overemphasized. Patient education is the cornerstone of patient engagement, and a prerequisite for other involvement strategies. The responsibility for educating patients is multidisciplinary and must be accentuated at all stages of hemodialysis care. Enhancing patient self-efficacy in preventing CABSIs requires them to have an adequate level of knowledge on infection prevention and the skills and confidence to self-care in the community. Providing patient education is the first step to empower patients, facilitating their ownership of their journey in care and safeguarding them from infections.
Model-based view planning for building inspection and surveillance using voxel dilation, Medial Objects, and Random-Key Genetic Algorithm
Authors: Jing Wei , Shimada Kenji 
Published: December 2017

Abstract
Model-based view planning is to find a near-optimal set of viewpoints that cover the surface of a target geometric model. It has been applied to many building inspection and surveillance applications with Unmanned Aerial Vehicle (UAV). Previous approaches proposed in the past few decades suffer from several limitations: many of them work exclusively for 2D problems, generate only a sub-optimal set of views for target surfaces in 3D environment, and/or generate a set of views that cover only part of the target surfaces in 3D environment. This paper presents a novel two-step computational method for finding near-optimal views to cover the surface of a target set of buildings using voxel dilation, Medial Objects (MO), and Random-Key Genetic Algorithm (RKGA). In the first step, the proposed method inflates the building surfaces by voxel dilation to define a sub-volume around the buildings. The MO of this sub-volume is then calculated, and candidate viewpoints are sampled using Gaussian sampling around the MO surface. In the second step, an optimization problem is formulated as (partial) Set Covering Problem and solved by searching through the candidate viewpoints using RKGA and greedy search. The performance of the proposed two-step computational method was measured with several computational cases, and the performance was compared with two previously proposed methods: the optimal-scan-zone method and the randomized sampling-based method. The results demonstrate that the proposed method outperforms the previous methods by finding a better solution with fewer viewpoints and higher coverage ratio compared to the previous methods.
Highlights A two-step “generate-test” view planning method is proposed. Voxel dilation, Medial Objects and Gaussian sampling are used to generate viewpoints. Random-Key GA and Greedy search are combined to solve the Set Covering Problem. The proposed method is benchmarked and outperforms two existing methods.