bluuebunny/crossref_metadata_2025_split huggingface dataset:
OMIP‐035: Functional analysis of natural killer cell subsets in macaques
Authors: Weisgrau Kim L. , Ries Moritz , Pomplun Nicholas , Evans David T. , Rakasz Eva G. 
Published: August 2016

AbstractThis panel was developed to measure the functional capability of natural killer (NK) cell subsets in rhesus macaques (Macaca mulatta). It includes markers to determine the frequency of cytokine secreting and cytotoxic NK cell subpopulations in peripheral blood mononuclear cell (PBMC) samples stimulated in vitro with human 721.221 cells. NK cell subsets were defined by the expression of killer cell immunoglobulin‐like receptors (KIRs) Mamu‐KIR3DL01 and Mamu‐KIR3DL05, and differentiation antigens CD16 and CD56. The panel can be used to assess the functional capability of NK cells in a range of normal and pathologic conditions of captive bred rhesus macaques of Indian origin. © 2016 International Society for Advancement of Cytometry
Habitat associations in a recolonizing, low‐density black bear population
Authors: Sollmann Rahel , Gardner Beth , Belant Jerrold L. , Wilton Clay M. , Beringer Jeff 
Published: August 2016

AbstractAmerican black bears are closely associated with forest habitat. They were nearly extirpated from the Central Interior Highlands, United States, in the early twentieth century, but have recolonized this part of the range since the 1960s. Due to lower population densities (as a result of recent recolonization), we hypothesized that bears in this region would show strong associations with forest habitat at both the home range and landscape scale. To test this, we analyzed hair snare and GPS telemetry data from five sampling grids with a combined spatial capture–recapture and resource selection function model to investigate individual space use within home ranges and landscape scale variation in density of black bears in the southern Missouri part of the Interior Highlands. We performed a linear discriminant analysis to identify habitat correlates of black bear density. We found that at the home range level, bears selected for more forested habitat and steeper slopes. Black bear density varied among sampling grids from 0.842 to 10.248 individuals/100 km2 which is at the low end of the spectrum of reported black bear densities. There were no clear habitat correlates for among‐grid variation in density, but in the three higher‐density grids, density declined with increasing forest cover and increasing distance from human settlements. This suggests that the bear populations benefited from more heterogeneous habitat and that rural settlements may represent food resources. Exploiting these anthropogenic resources could be facilitated by the fact that bears in our study were not hunted and were viewed as a novelty rather than a nuisance, which may lead to low perceived risk from anthropogenic sources. Our results highlight the need to interpret habitat associations of American black bears not only at local scales but also in the landscape context.
Large reptiles and cold temperatures: Do extreme cold spells set distributional limits for tropical reptiles in Florida?
Authors: Mazzotti Frank J. , Cherkiss Michael S. , Parry Mark , Beauchamp Jeff , Rochford Mike , Smith Brian , Hart Kristen , Brandt Laura A. 
Published: August 2016

AbstractDistributional limits of many tropical species in Florida are ultimately determined by tolerance to low temperature. An unprecedented cold spell during 2–11 January 2010, in South Florida provided an opportunity to compare the responses of tropical American crocodiles with warm‐temperate American alligators and to compare the responses of nonnative Burmese pythons with native warm‐temperate snakes exposed to prolonged cold temperatures. After the January 2010 cold spell, a record number of American crocodiles (n = 151) and Burmese pythons (n = 36) were found dead. In contrast, no American alligators and no native snakes were found dead. American alligators and American crocodiles behaved differently during the cold spell. American alligators stopped basking and retreated to warmer water. American crocodiles apparently continued to bask during extreme cold temperatures resulting in lethal body temperatures. The mortality of Burmese pythons compared to the absence of mortality for native snakes suggests that the current population of Burmese pythons in the Everglades is less tolerant of cold temperatures than native snakes. Burmese pythons introduced from other parts of their native range may be more tolerant of cold temperatures. We documented the direct effects of cold temperatures on crocodiles and pythons; however, evidence of long‐term effects of cold temperature on their populations within their established ranges remains lacking. Mortality of crocodiles and pythons outside of their current established range may be more important in setting distributional limits.
River Management and Stakeholders' Participation: The case of the Rhone River, a fragmented institutional setting
Authors: Bréthaut Christian 
Published: August 2016

AbstractThere have been many authors who have examined the question of participation and the extent of its influence in water management. The empowerment of stakeholders in decision‐making processes has been a major issue in this field. The involvement of different types of public actor can be enacted in different manners and depends strongly on how the decision‐making process works in reality, on the extent to which actors are truly able to be active in this new participatory process and on who holds the responsibility for its implementation. These variables underline the various obstacles that face the implementation of a true intersectoral participation, one that successfully involves all water users. This article uses the case study of the Rhone River to explore the issues of public participation within a transboundary river where no international basin organization has been able to successfully regroup the different initiatives. I consider this example to be particularly interesting, as it allows for a comparison between different arenas that are not linked, yet are active within the same river basin. In acknowledgement of the increasing number of participatory initiatives, the article highlights and considers the difficulties associated with the implementation of participation within and between fragmented participation arenas. This article proposes an analysis of the different participation arenas of the river through the lens of three analytical variables:social efficiency,substantial efficiencyandprocedural efficiency. The focus turns to the impact of such a participation structure and questions the increased number of arenas in which stakeholders participate regarding watershed management. Copyright © 2016 John Wiley & Sons, Ltd and ERP Environment
Two Novelties in Ion‐pair Formation‐based Potentiometric Titrations of Anionic Surfactants
Authors: Mikysek Tomáš , Stočes Matěj , Vytřas Karel 
Published: August 2016

AbstractTwo novel approaches in ion‐pair formation‐based potentiometric titrations of anionic surfactants are presented. First, a new type of the low ohmic coated‐wire ion‐selective electrode is introduced; the polymeric membrane containing a plasticizer mixed with carbon powder. Second, didecyldimethylammonium chloride as the cationic titrant is for the first time proposed and applied, providing the titration curves with the highest potential jump.
A Two‐step Strategy for the Selective and Sensitive Detection of Dopamine with Glassy Carbon Electrodes
Authors: Wang Jianan , Wang Jichang 
Published: August 2016

AbstractA new strategy is developed for using cyclic voltammetry technique to achieve sensitive and selective detection of dopamine on glassy carbon electrodes. The proposed method involves two steps, in which the cyclic voltammetric measurement is preceded by a brief period of potentiostatic treatment of the analyte solution. With this two‐step strategy redox peaks could be seen at dopamine concentration as low as 5 μM. In the co‐presence of ascorbic acid and uric acid, there are three well‐resolved anodic peaks with the peak separation between ascorbic acid and dopamine larger than 230 mV. The fact that no pre‐modification of the glassy carbon electrode is needed and the glassy carbon electrodes can be readily recovered after each measurement makes this new method attractive for the sensitive detection of dopamine.
Building and Leveraging Dynamic Capabilities: Insights from Accelerated Innovation in China
Authors: Williamson Peter J. 
Published: August 2016

Plain language summaryThis article explores what we can learn from a set of Chinese companies who have successfully pursued a strategy of accelerated innovation about building and leveraging dynamic capabilities. We conclude that creating flexible organizational structures and processes is key. The resulting dynamic capabilities can help achieve sustainable competitive advantage by spawning a series of innovations that enable a company to ‘run faster’ than competitors. These capabilities depend, in part, on the perceptions and behaviors of the firm's staff. Almost without exception, however, they have their roots in characteristics of the local environment. Such dynamic capabilities will be difficult to transfer and deploy overseas. A firm's ability to sustain competitive advantage abroad, therefore, depends on choosing foreign markets that share similarities with the firm's home base.Technical summaryThe dynamic capabilities framework was developed in the context of markets characterized by rapid technological change. Globalization means that firms in many industries now need similar capabilities to achieve and sustain competitive advantage. But the nature of these capabilities, their antecedents, and how they can underpin sustainable competitive advantage are incompletely understood. This article draws on a set of case studies of successful Chinese innovators to examine these questions. The dynamic capabilities we observe are underpinned by a set of processes that are themselves dynamic and flexible, rather than fixed, repeatable routines. Their antecedents mostly lie in qualities of the local environment. Hence, they tend to be context dependent, with consequent limitations in their transferability and applicability to sustaining competitive advantage in foreign markets. Copyright © 2016 Strategic Management Society.
Sex‐specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100 ppb embryonic lead exposure
Authors: Lee Jinyoung , Peterson Samuel M. , Freeman Jennifer L. 
Published: August 2016

AbstractDevelopmental lead (Pb) exposure is suggested in laboratory studies to be a trigger for neurodegenerative diseases such as Alzheimer's disease (AD). Sortilin‐related receptor, L (DLR class) A repeats‐containing (SORL1) is a recently identified AD genetic risk factor. SORL1 has limited characterization in vertebrate models in comparison to other AD genetic risk factors. To characterize SORL1 further, protein sequence homology between humans, mice and zebrafish was analyzed and showed conservation of functional repeats and domain orientation. Next, spatial expression of sorl1 in zebrafish larvae was completed and diffuse expression in neural tissue that was not restricted to the brain was observed. Influences of sex and age on quantitative expression of sorl1 in the brain of adult zebrafish were then assessed. Sex‐specific alteration of sorl1 expression transpired during the aging process in females. The zebrafish was then utilized to investigate the impacts of a 100 ppb embryonic Pb exposure on sorl1 expression and other known AD genetic risk factors. Sex‐specific quantitative gene expression analysis was completed with adult zebrafish brain to compare those developmentally exposed to Pb or a control treatment, but no significant difference in sorl1 expression or other AD genetic risk factors was observed. Overall, this study provided characterization of sorl1 with changes in brain expression during aging being female‐specific. This finding is in agreement with females being more prone to the onset of AD, but analysis of additional AD genetic risk factors is needed to facilitate our understanding of the impact of a 100 ppb embryonic Pb exposure. Copyright © 2016 John Wiley & Sons, Ltd.
“Black cloud” vs. “white cloud” physicians – Myth or reality in apheresis medicine?
Authors: Pham Huy P. , Raju Dheeraj , Jiang Ning , Williams Lance A. 
Published: August 2016

AbstractBackgroundMany practitioners believe in the phenomenon of either being labeled a “black cloud” or “white cloud” while on‐call. A “white‐cloud” physician is one who usually gets fewer cases. A “black‐cloud” is one who often has more cases. It is unclear if the designation is only superstitious or if there is some merit. Our aim is to objectively assess this phenomenon in apheresis medicine at our center.MethodsA one‐year prospective study from 12/2014 to 11/2015 was designed to evaluate the number of times apheresis physicians and nurses were involved with emergent apheresis procedures between the hours from 10 PM and 7 AM. Other parameters collected include the names of the physician, apheresis nurse, type of emergent apheresis procedure, day of the week, and season of the year.ResultsDuring the study period, 32 emergent procedures (or “black‐cloud” events) occurred. The median time between two consecutive events was 8 days (range: 1–34 days). We found no statistically significant association between the “black‐cloud” events and attending physicians, nurses, day of the week, or season of the year by Chi‐square and Fisher's analyses. However, exploratory analysis using association rule demonstrated that “black‐cloud” events were more likely to happen on Thursday (2.19 times), with attending physician 2 (1.18 times), and during winter (1.15 times).ConclusionThe results of this pilot study may support the common perception that some physicians or nurses are either “black cloud” or “white cloud”. A larger, multi‐center study population is needed to validate the results of this pilot study.
Elastic properties of hydrogels and decellularized tissue sections used in mechanobiology studies probed by atomic force microscopy
Authors: Giménez Alícia , Uriarte Juan José , Vieyra Joan , Navajas Daniel , Alcaraz Jordi 
Published: August 2016

AbstractThe increasing recognition that tissue elasticity is an important regulator of cell behavior in normal and pathologic conditions such as fibrosis and cancer has driven the development of cell culture substrata with tunable elasticity. Such development has urged the need to quantify the elastic properties of these cell culture substrata particularly at the nanometer scale, since this is the relevant length scale involved in cell‐extracellular matrix (ECM) mechanical interactions. To address this need, we have exploited the versatility of atomic force microscopy to quantify the elastic properties of a variety of cell culture substrata used in mechanobiology studies, including floating collagen gels, ECM‐coated polyacrylamide gels, and decellularized tissue sections. In this review we summarize major findings in this field from our group within the context of the state‐of‐the‐art in the field, and provide a critical discussion on the applicability and complementarity of currently available cell culture assays with tunable elasticity. In addition, we briefly describe how the limitations of these assays provide opportunities for future research, which is expected to continue expanding our understanding of the mechanobiological aspects that support both normal and diseased conditions. Microsc. Res. Tech. 80:85–96, 2017. © 2016 Wiley Periodicals, Inc.
Optimization and evaluation of reference region variable flip angle (RR‐VFA) and T1 Mapping in the Prostate at 3T
Authors: Rangwala Novena A. , Dregely Isabel , Wu Holden H. , Sung Kyunghyun 
Published: August 2016

PurposeTo optimize and evaluate the reference region variable flip angle (RR‐VFA) technique for simultaneous
and T1 mapping of the prostate at 3 Tesla (T).Materials and MethodsThe fat region surrounding the prostate was first identified using a fractional fat segmentation constant (tF) and a signal fat‐fraction threshold (rF), and the relative flip angle (FA) was characterized using an effective fat T1 (T1f) within the fat region. Optimal values of tF, rF, and T1f were chosen by comparing relative FA maps using RR‐VFA (ARR‐VFA) with a reference relative FA maps (AREF) in the surrounding fat and evaluating interpolation errors within the prostate. The optimized RR‐VFA was evaluated in volunteers at 3T on a single scanner (n = 10) and across three scanners (n = 4).ResultstF, rF and T1f were optimized as 0.5, 90%, and 320 ms, respectively. Prostate ARR‐VFA showed differences of 30% among volunteers on one scanner, with no significant differences between ARR‐VFA and AREF (P = 0.41). Prostate T1 after
correction was 1998 ± 113 ms with significantly (P = 0.004) lower standard deviation than T1 before
correction. The average coefficient of variation of prostate T1 across multiple scanners decreased from 15% to 5% after
correction.ConclusionThe optimized RR‐VFA can simultaneously measure
and T1 in the prostate without the need for an additional scan and improve T1 consistency within and across MRI scanners at 3T.Level of Evidence: 3J. Magn. Reson. Imaging 2017;45:751–760.
Thermal Decomposition Kinetics of Ginkgo biloba Leaves Polyprenol in Nitrogen Atmosphere
Authors: Zhang Chang‐Wei , Wang Cheng‐Zhang , Tao Ran 
Published: August 2016

ABSTRACTThe nonisothermal decomposition kinetics of Ginkgo biloba leaves polyprenol (GBP) and cleaved situation of its chemical bond during thermal decomposition process were first investigated using thermogravimetric (TG) and TG‐FTIR technology. The results of thermal decomposition kinetics revealed that the nonisothermal decomposition mechanism of GBP corresponds to first‐order chemical reaction with n = 1, integral form g(a) = –ln(1 – a) and differential form f(a) = 1 – a. TG‐FTIR results demonstrated that absorbance of –CH3, unsaturated C–H bond, =CH2, accumulated C=C, –OH, and so on constantly increased with thermal decomposition reaction went on. In addition, storage life of GBP was also evaluated. These data could provide theoretical guidance for purification under high temperature and other thermal application of GBP.
Prospective multi‐institutional transnasal esophagoscopy: Predictors of a change in management
Authors: Howell Rebecca J. , Pate Mariah B. , Ishman Stacey L. , Isseroff Tova F. , Rubin Adam D. , Soliman Ahmed M. , Postma Gregory N. , Pitman Michael J. 
Published: August 2016

Objectives/HypothesisTo evaluate clinical indications and endoscopic findings for patients undergoing transnasal esophagoscopy (TNE).Study DesignProspective, multi‐institutional, observational cohort study at four tertiary centers.MethodsDemographics, reflux finding score, reflux symptom index, Eating Assessment Tool (EAT‐10) scores, clinical indications, and endoscopic findings were compared among patients whose TNE findings resulted in a changes in management (FCIM), defined as a referral, new medication, or surgery recommendation.ResultsOf the 329 patients who were enrolled nine (3%) were unable to complete the exam. In an adjusted regression model, male gender and elevated body mass index were significantly predictive of a positive TNE (P =.013‐.045); 51% (n = 162/319) had TNE with FCIM. Common FCIM were esophageal stricture (7.5%), irregular Z‐line (27.4%), reflux esophagitis (12.8%), and infectious esophagitis (6.3%) (P <.001‐.010). Overall, the average EAT‐10 was higher for patients with FCIM (9.7 vs. 5.4) than in those without it (P =.014). Patients with a history of head and neck cancer (HNCA) had FCIM 64% of the time, which rose to 81% if they had both HNCA and dysphagia.ConclusionsIn treatment‐seeking patients TNE is predictive of a change in management in males and obese patients. In patients with HNCA and dysphagia, TNE is likely to yield findings that cause a change in management.Level of Evidence2b. Laryngoscope, 126:2667–2671, 2016
Psychosocial outcomes of an electronic self‐report assessment and self‐care intervention for patients with cancer: a randomized controlled trial
Authors: Fann Jesse R. , Hong Fangxin , Halpenny Barbara , Blonquist Traci M. , Berry Donna L. 
Published: August 2016

AbstractBackgroundThe use of Web‐based technology to facilitate self‐care and communication with health care providers has the potential to improve psychosocial outcomes for patients undergoing cancer treatment. This study reports an analysis of psychosocial outcomes of the electronic self‐report assessment for cancer study.MethodsAdult patients starting cancer therapy were randomized to receive usual education about symptoms and quality of life topics (control) or usual education plus self‐care instruction for symptoms and quality of life issues, communication coaching, and the opportunity to track symptoms and quality of life between clinic visits (intervention). Depression (Patient Health Questionnaire‐9) and social, emotional, and role functioning (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 subscales) were measured before treatment (T1), 3 to 6 weeks after starting treatment (T2), 2 weeks later (T3), and 2 to 4 weeks after treatment ended or at the next restaging visit for participants who continued to receive treatment (T4). Clinicians received summaries of participant reports at each time point in both groups.ResultsIn multivariable analysis, the depression scores were significantly lower (P = .04) and there was a trend to higher social and role functioning (P = .07) in the intervention group compared with the control. Working status was significantly associated with lower depression and better social and role functioning.ConclusionsA patient‐centered, Web‐based intervention that facilitates self‐care and communication can improve psychosocial outcomes in the cancer setting.
Response to: “Comment on benchmarking compressed sensing, super‐resolution, and filter diagonalization”
Authors: Markovich Thomas , Blau Samuel M. , Sanders Jacob N. , Aspuru‐Guzik Alán 
Published: August 2016

AbstractIn light of a recent comment by Vladimir Mandelshtam, we provide a brief, theoretically motivated, justification of our methodology. We show that our
error metric provides a valid lower bound for the parameter estimation error through both exact calculations and numerical examples. Additionally, we prove the validity of Parseval?s identity.