bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Charge Transport Layer for Perovskite Light‐Emitting Diodes
Authors: Li Yuqing , Guan Xiang , Zhao Yaping , Zhang Qin , Chen Xi , Zhang Shaopeng , Lu Jianxun , Wei Zhanhua 
Published: October 2024

AbstractPerovskite light‐emitting diodes (Pero‐LEDs) have garnered significant attention due to their exceptional emission characteristics, including narrow full width at half maximum, high color purity, and tunable emission colors. Recent efficiency and operational stability advancements have positioned Pero‐LEDs as a promising next‐generation display technology. Extensive research and review articles on the compositional engineering and defect passivation of perovskite layers have substantially contributed to the development of multi‐color and high‐efficiency Pero‐LEDs. However, the crucial aspect of charge transport layer (CTL) modulation in Pero‐LEDs remains relatively underexplored. CTL modulation not only impacts the charge carrier transport efficiency and injection balance but also plays a critical role in passivating the perovskite surface, blocking ion migration, enhancing perovskite crystallinity, and improving light extraction efficiency. Therefore, optimizing CTLs is pivotal for further enhancing Pero‐LED performance. Herein, this review discusses the roles of CTLs in Pero‐LEDs and categorizes both reported and potential CTL materials. Then, various CTL optimization strategies are presented, alongside an analysis of the selection criteria for CTLs in high‐performance Pero‐LEDs. Finally, a summary and outlook on the potential of CTL modulation to further advance Pero‐LED performances are provided.
Narrow‐Band Emission of Asymmetric 1,3‐Substituted Pyrene‐Based Deep‐Blue Emitters and Application in OLEDs
Authors: Liu Wei , Jin Pengcheng , Zhang Sheng , Wang Xiaohui , Xie Zhixin , Xiao Ye , Hu Jian‐Yong , Redshaw Carl , Feng Xing 
Published: October 2024

AbstractHigh‐efficiency organic blue light‐emitting materials with narrow‐band emission are fundamental components for constructing high color purity and high resolution in high‐performance organic light‐emitting diode (OLED) devices. Herein, new pyrene‐based blue emitters (8–10) with narrow‐band emission are synthesized by asymmetrically introducing biphenyl and triphenylamine units at the 1‐ and 3‐positions of pyrene, respectively. Due to the steric effect and through‐space conjugation, the synergistic effects of both groups not only boost these emitters 8–10 (CIEy < 0.11) with aggregation‐induced emission (AIE) characteristics and high fluorescence quantum yield (>0.68), but also endow narrow full width at half maxima (FWHM) emission (≤36 nm) in the crystallized state (FWHM ≤ 55 nm in the film state). The EL spectra of pyrene‐based 8–10 in nondoped OLEDs exhibit blue emission with a maximum emission (λmax em) in the range of 448–453 nm (CIEy ≤ 0.12). The compounds 8–10 in doped‐OLEDs show a blue emission with a λmax em in the range of 443–445 nm and CIEy ≤ 0.08, with FWHM emission of 57–61 nm. The compound 10‐based doped OLED displays an impressive EL performance with a maximum brightness of 9756 cd m−2 and a maximum external quantum efficiency of 2.58%.
Investigation of the Physical Properties of 211 MAX Phase Material Cr2TlN${\rm Cr}_2{\rm TlN}$ with DFT and DFT+U Methods
Authors: Srinivasan Vijay , Rana Tushar H 
Published: October 2024

AbstractThis study utilizes Perdew‐Burke‐Ernzerhof (PBE) and PBE+U exchange‐correlation functionals to investigate the electronic, magnetic, and structural properties of . The spin polarization calculations indicate that the predicted material exhibits ferromagnetic properties in bulk when U = 0 eV. As the U parameter increases from 0 to 1 eV, it demonstrates antiferromagnetic behavior with the spin magnetic moment per Cr atom of 2.17 . The supercell method reveals that the in‐plane antiferromagnetic 1 (in‐AFM1) state is more stable than the ferromagnetic state, in‐AFM2, and in‐AFM3 when U equals 0 eV and 1 eV, respectively. The analysis of the electron band structures and density of states suggests that displays metallic characteristics due to the hybridization of Cr‐d with N‐p and Cr‐d with Tl‐p states. The predicted compound is found to be mechanically stable as per the Born–Huang criteria. The elastic moduli are successfully assessed using the Voigt–Reuss–Hill approximation. Poisson's and Pugh's ratios show that is ductile in nature. The low Young's modulus value and minimum thermal conductivity suggest that could be an excellent candidate for thermal barrier coating applications. Further, the projected material undergoes confirmation of its dynamic stability via phonon spectra analysis, showing no negative or imaginary frequencies.
Prolonged Survival of Neutrophils Induced by Tumor‐Derived G‐CSF/GM‐CSF Promotes Immunosuppression and Progression in Laryngeal Squamous Cell Carcinoma
Authors: Zhu Xiaoke , Heng Yu , Ma Jingyu , Zhang Duo , Tang Di , Ji Yangyang , He Changding , Lin Hanqing , Ding Xuping , Zhou Jian , Tao Lei , Lu Liming 
Published: October 2024

AbstractTumor‐associated neutrophils (TANs) play a crucial role in tumor progression and exhibit prolonged survival. However, the mechanism underlying their extended lifespan and significance in laryngeal squamous cell carcinoma (LSCC) remains unclear. Herein, it is observed that apoptosis of TANs is significantly delayed owing to induction by tumor‐derived G‐CSF and GM‐CSF through the activation of the PI3K‐AKT signaling pathway, upregulation of anti‐apoptotic Mcl‐1 expression, and downregulation of activated Caspase‐3 levels. It is found that prolonged survival of TANs leads to the accumulation of aged CXCR4+ neutrophils that exhibit potent immunosuppressive properties and are associated with poor patient prognosis. Furthermore, extended survival promotes the enhanced immunosuppressive function of CD8+ T cells by TANs, thereby facilitating the in vitro and in vivo progression and growth of human LSCC tumors. Importantly, this effect could be reversed by blocking G‐CSF and GM‐CSF stimulation of neutrophils. These findings elucidate the pivotal role of pathologically prolonged neutrophil survival in impairing CD8+ T cell immunity and suggest targeting it as a potential therapeutic strategy for tumors.
Microfabrication Technologies for Nanoinvasive and High‐Resolution Magnetic Neuromodulation
Authors: Ge Changhao , Masalehdan Tahereh , Shojaei Baghini Mahdieh , Duran Toro Vicente , Signorelli Lorenzo , Thomson Hannah , Gregurec Danijela , Heidari Hadi 
Published: October 2024

AbstractThe increasing demand for precise neuromodulation necessitates advancements in techniques to achieve higher spatial resolution. Magnetic stimulation, offering low signal attenuation and minimal tissue damage, plays a significant role in neuromodulation. Conventional transcranial magnetic stimulation (TMS), though noninvasive, lacks the spatial resolution and neuron selectivity required for spatially precise neuromodulation. To address these limitations, the next generation of magnetic neurostimulation technologies aims to achieve submillimeter‐resolution and selective neuromodulation with high temporal resolution. Invasive and nanoinvasive magnetic neurostimulation are two next‐generation approaches: invasive methods use implantable microcoils, while nanoinvasive methods use magnetic nanoparticles (MNPs) to achieve high spatial and temporal resolution of magnetic neuromodulation. This review will introduce the working principles, technical details, coil designs, and potential future developments of these approaches from an engineering perspective. Furthermore, the review will discuss state‐of‐the‐art microfabrication in depth due to its irreplaceable role in realizing next‐generation magnetic neuromodulation. In addition to reviewing magnetic neuromodulation, this review will cover through‐silicon vias (TSV), surface micromachining, photolithography, direct writing, and other fabrication technologies, supported by case studies, providing a framework for the integration of magnetic neuromodulation and microelectronics technologies.
RGB‐Single‐Chip OLEDs for High‐Speed Visible‐Light Communication by Wavelength‐Division Multiplexing
Authors: Yoshida Kou , Chen Cheng , Haas Harald , Turnbull Graham A. , Samuel Ifor D. W. 
Published: October 2024

AbstractOrganic light‐emitting diodes (OLEDs) have been developed for high‐speed transmitters of visible‐light communication (VLC) but so far the possibility of direct fabrication of multiple colors on a single substrate has not been exploited for multi‐Gbps data transmission. Very fast red‐, green‐, and blue (RGB)‐emitting OLEDs are developed on a single substrate to realize high data transmission speed by wavelength division multiplexing (WDM). −6 dB electrical bandwidth of over 100 MHz is achieved for all colors by selecting fluorescent materials with nanosecond emission lifetimes and little overlap between their emission spectra and incorporating them into OLEDs designed for high‐speed operation. Optical microcavities in top‐emitting OLED structures are used to minimize spectral overlap. A record data transmission rate for an OLED transmitter system of 3.2 Gbps is demonstrated, by transmitting data with the 3 colors simultaneously and separating each data by dichroic mirrors. The results show that WDM with integrated RGB pixels is a useful way to increase the data transmission rate of a VLC system based on OLED transmitters, which has the potential to enable multi‐gigabit transmission by displays. The availability of high‐speed multiple‐color devices as developed here also expands applications of OLEDs for spectroscopy, sensing, and ranging.
Unfractionated Heparin Enhances Sepsis Prognosis Through Inhibiting Drp1‐Mediated Mitochondrial Quality Imbalance
Authors: Liu Ruixue , Huang He , Hou Dongyao , Hao Shuai , Guo Qiao , Liao Haitang , Song Rui , Tian Yu , Chen Qian , Luo Zhenchun , Ma Daqing , Liu Liangming , Duan Chenyang 
Published: October 2024

AbstractUnfractionated heparin (UFH) is commonly used as an anticoagulant in sepsis treatment and has recently been found to have non‐anticoagulant effects, but underlying mechanisms remain unclear. This retrospective clinical data showed that UFH has significant protective effects in sepsis compared to low‐molecular‐weight heparin and enoxaparin, indicating potential benefits of its non‐anticoagulant properties. Recombinant protein chip screening, surface plasmon resonance, and molecular docking data demonstrated that UFH specifically bound to the cytoplasmic Drp1 protein through its zone 2 non‐anticoagulant segment. In‐vitro experiments verified that UFH's specific binding to Drp1 suppressed Drp1 translocation to mitochondria following “sepsis” challenge, thereby improving mitochondrial morphology, function and metabolism in vascular endothelial cells. Consequently, UHF comprehensively protected mitochondrial quality, thus reducing vascular leakage and improving prognosis in a sepsis rat model. These findings highlight the potential of UFH as a sepsis treatment strategy targeting non‐anticoagulation mechanism.
Intralayer/Interlayer Codoping Stabilizes Polarity Modulation in 2D Semiconductors for Scalable Electronics
Authors: Qiu Guitian , Kong Lingan , Han Mengjiao , Zhang Qian , Rehman Majeed Ur , Yi Jianxian , Xian Lede , Lin Xiankai , Abbas Aumber , Chen Jiwei , Luo Yingjie , Li Wenbo , Wei Zhongchao , Meng Hongyun , Ma Xiuliang , Liang Qijie 
Published: October 2024

Abstract2D semiconductors show promise as a competitive candidate for developing future integrated circuits due to their immunity to short‐channel effects and high carrier mobility at atomic layer thicknesses. The inherent defects and Fermi level pinning effect lead to n‐type transport characteristics in most 2D semiconductors, while unstable and unsustainable p‐type doping by various strategies hinders their application in many areas, such as complementary metal‐oxide‐semiconductor (CMOS) devices. In this study, an intralayer/interlayer codoping strategy is introduced that stabilizes p‐type doping in 2D semiconductors. By incorporating oppositely charged ions (F and Li) with the intralayer/interlayer of 2D semiconductors, remarkable p‐type doping in WSe2 and MoTe2 with air stability up to 9 months is achieved. Notably, the hole mobility presents a 100‐fold enhancement (0.7 to 92 cm2 V−1 s−1) with the codoping procedure. Structural and elemental characterizations, combined with theoretical calculations validate the codoping mechanism. Moreover, a CMOS inverter and more complex logic functions such as NOR and XNOR, as well as large‐area device arrays are demonstrated to showcase its applications and scalability. These findings suggest that stable and straightforward intralayer/interlayer codoping strategy with charge‐space synergy holds the key to unlocking the potential of 2D semiconductors in complex and scalable device applications.
Total Synthesis of Berkeleyone A and Preaustinoid A through Epoxypolyene Cyclization
Authors: Li Xingyi , Chang Zhifang , Duan Shengfu , Xie Zhixiang 
Published: October 2024

AbstractA bioinspired Lewis acid‐catalyzed epoxypolyene cyclization was developed to construct the tetracyclic framework containing a bicyclo[3.3.1]nonane core and seven chiral centers. The usage of this approach for assembling these natural products of 6/6/6/6 tetracyclic skeleton with bicyclo[3.3.1]nonane core is demonstrated by the total synthesis of highly oxidized berkeleyone A and preaustinoid A.
Application of Hard and Soft Acid‐base Theory to Construct Heterometallic Materials with Metal‐oxo Clusters
Authors: Qi Xiao , Xie Yu‐Long , Niu Jing‐Yang , Zhao Jun‐Wei , Li Ya‐Min , Fang Wei‐Hui , Zhang Jian 
Published: October 2024

AbstractHeterometallic cluster‐based materials offer the potential to incorporate multiple functionalities, leveraging the aggregation effects of clusters and translating this heterogeneity and complexity into unexpected properties that are more than just the sum of their components. However, the rational construction of heterometallic cluster‐based materials remains challenging due to the complexity of metal cation coordination and structural unpredictability. This minireview provides insights into a general synthetic strategy based on Hard and Soft Acids and Bases (HSAB) theory, summarizing its advantages in the designed synthesis of discrete heterometallic clusters (intracluster assembly) and infinite heterometallic cluster‐based materials (intercluster assembly). Furthermore, it emphasizes the potential to exploit the intrinsic properties of mixed components to achieve breakthroughs across a broad range of applications. The insights from this review are expected to drive the progress of heterometallic cluster‐based materials in a controllable and predictable manner.
Efficient Photodegradation of High Concentration Dye Pollutants by 3‐OH‐Ph‐C≡C‐Cu Under Sunlight Irradiation
Authors: Hou Jiawei , Jia Yibing , Liu Ya‐Ge , Jing Biyun , Mu Yueru , Zhang Yuanyuan , Wang Panfeng , Jiang Hai‐Ying 
Published: October 2024

ABSTRACTThis work designed and synthesized a series of functionalized copper phenylacetylides (R‐Ph‐C≡C‐Cu) for highly efficient degradation of dye pollutants with light irradiation. Different growth modes caused by the introduction of different functional groups were studied and demonstrated. Among all the prepared samples, 3‐OH‐Ph‐C≡C‐Cu performed the highest activity for methyl orange (MO) degradation under full spectrum light irradiation. Under full spectrum light and sunlight irradiation, the highest photodegradation capability of MO with the concentration of 600 mg/L can be achieved to 595.73 mg/g, which is about 30 times higher than the raw Ph‐C≡C‐Cu, 6.5 times higher than that by P25, and 18 times higher than that by g‐C3N4. It shows good universality for the conditions of basic room temperatures (20–50 °C), pH of 4–9 and the co‐existence of most ions. It also has good photodegradation effect on other dye pollutants, such as carmine, malachite green (MG), congo red (CR), and sunset yellow (SY). This highly efficient photodegradation of MO by 3‐OH‐Ph‐C≡C‐Cu is demonstrated to its strong hydrophilicity with the water contact angle of 35.1°, which results in the good contact of dye molecules on its surface. This work prepared an efficient photodegradation material and significantly improved the photodegradation capacity of dye pollutants. It is highly expected to achieve practical application in the treatment of industrial printing and dyeing wastewater.
2024: A “nucleoid space” odyssey featuring H‐NS
Authors: Rashid Fatema‐Zahra M. , Dame Remus T. 
Published: October 2024

AbstractThe three‐dimensional architecture of the bacterial chromosome is intertwined with genome processes such as transcription and replication. Conspicuously so, that the structure of the chromosome permits accurate prediction of active genome processes. Although appreciation of this interplay has developed rapidly in the past two decades, our understanding of this subject is still in its infancy, with research primarily focusing on how the process of transcription regulates and is regulated by chromosome structure. Here, we summarize the latest developments in the field with a focus on the interplay between chromosome structure and transcription in Escherichia coli (E. coli) as mediated by H‐NS—a model nucleoid structuring protein. We describe how the organization of chromosomes at the global and local scales is dependent on transcription, and how transcription is regulated by chromosome structure. Finally, we take note of studies that highlight our limited knowledge of structure‐function relationships in the chromosome, and we point out research tracks that will improve our insight in the topic.
Cytoskeletal mechanisms regulating attaching/effacing bacteria interactions with host cells: It takes a village to build the pedestal
Authors: Naydenov Nayden G. , Marino‐Melendez Armando , Campellone Kenneth G. , Ivanov Andrei I. 
Published: October 2024

AbstractThe actin cytoskeleton is a key cellular structure subverted by pathogens to infect and survive in or on host cells. Several pathogenic strains of Escherichia coli, such as enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC), developed a unique mechanism to remodel the actin cytoskeleton that involves the assembly of actin filament‐rich pedestals beneath the bacterial attachment sites. Actin pedestal assembly is driven by bacterial effectors injected into the host cells, and this structure is important for EPEC and EHEC colonization. While the interplay between bacterial effectors and the actin polymerization machinery of host cells is well‐understood, how other mechanisms of actin filament remodelling regulate pedestal assembly and bacterial attachment are poorly investigated. This review discusses the gaps in our understanding of the complexity of the actin cytoskeletal remodelling during EPEC and EHEC infection. We describe possible roles of actin depolymerizing, crosslinking and motor proteins in pedestal dynamics, and bacterial interactions with the host cells. We also discuss the biological significance of pedestal assembly for bacterial infection.
Construction of mitochondrial quality regulation genes‐related prognostic model based on bulk‐RNA‐seq analysis in multiple myeloma
Authors: Li Xiaohui , Zhang Ling , Liu Chengcheng , He Yi , Li Xudong , Xu Yichuan , Gu Cuiyin , Wang Xiaozhen , Wang Shuoting , Zhang Jingwen , Liu Jiajun 
Published: October 2024

AbstractMitochondrial quality regulation plays an important role in affecting the treatment sensitivity of multiple myeloma (MM). We aimed to develop a mitochondrial quality regulation genes (MQRGs)‐related prognostic model for MM patients. The Genomic Data Commons‐MM of bulk RNA‐seq, mutation, and single‐cell RNA‐seq (scRNA‐seq) dataset were downloaded, and the MQRGs gene set was collected previous study. “maftools” and CIBERSORT were used for mutation and immune‐infiltration analysis. Subsequently, the “ConsensusClusterPlus” was used to perform the unsupervised clustering analysis, “survminer” and “ssGSEA” R package was used for the Kaplan–Meier survival and enrichment analysis, “limma” R, univariate and Least Absolute Shrinkage and Selection Operator Cox were used for RiskScore model. The “timeROC” R package was used for Receiver Operating Characteristic Curve analysis. Finally, the “Seurat” R package was used for scRNA‐seq analysis. These MQRGs are mainly located on chromosome‐1,2,3,7, and 22 and had significant expression differences among age, gender, and stage groups, in which PPARGC1A and PPARG are the high mutation genes. Most MQRGs expression are closely associated with the plasma cells infiltration and can divide the patients into 2 different prognostic clusters (C1, C2). Then, 8 risk models were screened from 60 DEGs for RiskScore, which is an independent prognostic factor and effectively divided the patients into high and low risk groups with significant difference of immune checkpoint expression. Nomogram containing RiskScore can accurately predict patient prognosis, and a series of specific transcription factor PRDM1 and IRF1 were identified. We described the based molecular features and developed a high effective MQRGs‐related prognostic model in MM.
The association of diabetes mellitus and routinely collected patient‐reported outcomes in patients with cancer. A real‐world cohort study
Authors: Ose Dominik J. , Adediran Emmanuel , Mark Bayarmaa , Ocier Krista , Dunson JR William A. , Turner Cindy , Taylor Belinda , Svoboda Kim , Post Andrew R. , Leiser Jennifer , Colman Howard , Ulrich Cornelia M. , Hashibe Mia 
Published: October 2024

AbstractObjectiveCurrent studies have indicated that diabetes mellitus (DM) is highly prevalent in patients with cancer, but there is little research on consequences on the well‐being of patients during cancer treatment. This analysis evaluates the relationship between DM and patient‐reported outcomes (PRO) in patients with cancer, using a large and well‐characterized cohort.MethodsThis study utilized the Total Cancer Care protocol at the University of Utah Huntsman Cancer Institute. For this analysis, we integrated data from electronic health records, the Huntsman Cancer Registry, and routinely collected PRO questionnaires. We assessed the association between DM in patients with cancer and PRO scores for anxiety, depression, fatigue, pain interference, and physical function using multiple linear regression and t‐tests.ResultsThe final cohort comprised 3512 patients with cancer, with a mean age of 57.8 years at cancer diagnosis. Of all patients, 49.1% (n = 1724) were female, with 82.0% (n = 2879) patients reporting PROs at least at one time point. Compared with patients who responded, nonresponders were more often female (p = 0.0035), less frequently non‐Hispanic White (p = 0.0058), and had a higher BMI (p = 0.0759). Patients with cancer and diabetes had worse PRO scores for anxiety (p = 0.0003), depression (p < 0.0001), fatigue (p < 0.0001), pain interference (p < 0.0001), and physical function (p < 0.0001) compared to patients with cancer without diabetes. Significant associations between diabetes and PRO scores were observed for anxiety (β ± SE: 1.27 ± 0.48; p = 0.0076), depression (β ± SE: 1.46 ± 0.45; p = 0.0011), fatigue (β ± SE: 2.11 ± 0.52; p < 0.0001), pain interference (β ± SE: 1.42 ± 0.50; p = 0.0046), and physical function (β ± SE: −2.74 ± 0.48; p < 0.0001).ConclusionsThe results of this study suggest that patients with cancer and diabetes may be at greater risk for anxiety, depression, fatigue, higher pain interference, and reduced physical function. Strengthening diabetes management is imperative to address the negative impact of diabetes on PROs. In particular, this may be true for patients with skin, breast, prostate, and kidney cancer.