bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of low titer O whole blood in infants and young children undergoing cardiac surgery with cardiopulmonary bypass
Authors: Griselli Massimo , Said Sameh M. , Spinella Philip C. , Evans Michael , Cohn Claudia S. , Joyner Nitasha , Richtsfeld Martina , Fahey‐Arndt Kayla , Welbig Julie , Beilman Greg , Zantek Nicole D. , Steiner Marie E. 
Published: September 2024

AbstractBackgroundLow titer group O whole blood (LTOWB) is commonly used for severe bleeding in trauma patients. LTOWB may also benefit young children requiring cardiac surgery with cardiopulmonary bypass (CPB) at risk of severe bleeding.Study Design and MethodsIn this retrospective study, children <2 years old who underwent cardiac surgery with CPB were included. Comparisons were performed between those receiving component therapy (CT) versus those receiving LTOWB plus CT (LTOWB+CT). Outcomes included drainage tube (DT) output and total transfusion volumes. Optimization‐based weighting was used for adjusted analyses between groups.ResultsThere were 117 patients transfused with only CT and 127 patients transfused with LTOWB+CT. In the LTOWB+CT group, 66 were Group non‐O and 61 were Group O. Total transfusion volumes given from the start of the operation until the first 24 h in the cardiac intensive care unit was a median (IQR) 41 (10, 93) mL/kg in the CT group and 48 (28, 77) mL/kg in the LTOWB+CT group, (p = .28). Median (IQR) DT output was 22 (15–32) in CT versus 22 (16–28) in LTOWB+CT groups, (p = .27). There were no differences in death, renal failure and a composite of death and renal failure between the two groups, but there were statistically fewer re‐explorations for bleeding in the LTOWB+CT group (p < .001).ConclusionsThe use of LTOWB appears to be safe in <2 years old undergoing cardiac surgery and may reduce re‐explorations for severe bleeding. Large trials are needed to determine the efficacy and safety of LTOWB in this population with severe bleeding.
Comparison of Rim Sealing Effectiveness in Different Geometrical Configurations
Authors: Orsini L. , Picchi A. , Facchini B. , Bonini A. , Innocenti L. 
Published: September 2024

Abstract
The flow field developing inside the stator–rotor cavities of gas turbines is characterized by a complex unsteady behavior which still requires expensive and time consuming computational fluid dynamics simulations to be accurately modeled. Hence, the experimental characterization of the rim sealing effectiveness by means of scaled down geometries that replicate the rim seals found in actual engines still represent a widely used approach in literature. However, the obtained results can greatly depend on the specific geometry of the tested rim seal. Moreover, different geometrical parameters can vary during the operation of the engine, especially under transient or off-design conditions, thus influencing the resulting effectiveness values. For this reason, the sealing performance of seven different configurations of radial rim seals has been investigated and the obtained dataset has been correlated by using the orifice model. Hence, a detailed comparison of the results allowed the evaluation of the impact of different values of axial overlap, different distances between the vanes trailing edge and the blades leading edge and different values of radial gap. In particular, a three times greater axial overlap and a modest increase in the distance between the trailing edge of the vanes and the leading edge of the blades were both found to provide a limited improvement in the sealing performance, with a respective average reduction in Φmin of approximately 5% and 6%. A radial gap 2.4 times greater was instead found to lead to an average increase in the required quantity of sealing flowrate of approximately 44%. Hence, the amount of purge flow required to fully seal a cavity was not found to exhibit a linear increase with the radial gap.
Preparing Future Change Agents: A Commitment to Social Justice
Authors: Ladda Shawn 
Published: September 2024

The 2024 American Kinesiology Association Undergraduate Education Network session included a keynote address titled “Preparing Future Change Agents: A Commitment to Social Justice.” From my lived experience, I learned much from being marginalized as a female athlete. Through reflecting on these experiences and my formal education, the question asked was, What were those pivotal experiences that developed attitudes and values toward all-consuming social justice? Besides having parents who reinforced that one can do anything they set their mind to do, living across the country and learning the value of diversity and having educationally impactful experiences in the “world classroom” had a huge impact on my valuing diversity. From my formal educational experiences, I remember few lecture-type classes. Content knowledge is important, but the more impactful classes and experiences were experiential and hands-on. The following are my reflections and recommendations for preparing future change agents.
Fire Recognition Method Based on PSO-BP Neural Network and ResNet50
Authors: Ren Jing , Shi Xiaoyan , Cao Xianghong 
Published: September 2024

The rapid development of modern society and continuous urbanization have resulted in a proliferation of functional buildings, which offer significant convenience to individuals, but pose significant fire hazards as well. How to detect the fire at the early stage is always the focus of research. This paper proposes a multi-information source fusion fire recognition method based on particle swarm optimization (PSO)-backpropagation (BP) neural networks and ResNet50. The PSO algorithm is applied to optimize the initial parameters of a BP neural network model, while data from three sensors — temperature, humidity and smoke — are integrated, through iterative training of the system, accurate recognition of sensor data can be achieved. Additionally, a method is proposed for the recognition of infrared fire images using ResNet50 and transfer learning. By improving the ResNet50 network model and migrating the ResNet50 pre-trained network weight, infrared fire image recognition accuracy is further enhanced. Then the sensor information recognition results and image information recognition results are input into the fuzzy system for fusion reasoning again, and the final decision is output according to the set fuzzy rules. Experimental findings demonstrate that the multi-information source fusion approach utilizing the PSO-BP neural network and ResNet50 significantly enhances the accuracy and response time of fire recognition, and achieves a remarkable recognition effect.
NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations
Authors: Lin Jessica J. , Horan Joshua C. , Tangpeerachaikul Anupong , Swalduz Aurélie , Valdivia Augusto , Johnson Melissa L. , Besse Benjamin , Camidge D. Ross , Fujino Toshio , Yoda Satoshi , Nguyen-Phuong Linh , Mizuta Hayato , Bigot Ludovic , Nobre Catline , Lee Jii Bum , Yu Mi Ra , Mente Scot , Sun Yuting , Kohl Nancy E. , Porter James R. , Shair Matthew D. , Zhu Viola W. , Felip Enriqueta , Cho Byoung Chul , Friboulet Luc , Hata Aaron N. , Pelish Henry E. , Drilon Alexander 
Published: September 2024

Abstract
Three generations of tyrosine kinase inhibitors (TKI) have been approved for anaplastic lymphoma kinase (ALK) fusion–positive non–small cell lung cancer. However, none address the combined need for broad resistance coverage, brain activity, and avoidance of clinically dose-limiting TRK inhibition. NVL-655 is a rationally designed TKI with &gt;50-fold selectivity for ALK over 96% of the kinome tested. In vitro, NVL-655 inhibits diverse ALK fusions, activating alterations, and resistance mutations, showing ≥100-fold improved potency against ALKG1202R single and compound mutations over approved ALK TKIs. In vivo, it induces regression across 12 tumor models, including intracranial and patient-derived xenografts. NVL-655 inhibits ALK over TRK with 22-fold to &gt;874-fold selectivity. These preclinical findings are supported by three case studies from an ongoing first-in-human phase I/II trial of NVL-655 which demonstrate preliminary proof-of-concept clinical activity in heavily pretreated patients with ALK fusion–positive non–small cell lung cancer, including in patients with brain metastases and single or compound ALK resistance mutations.
Significance: By combining broad activity against single and compound ALK resistance mutations, brain penetrance, and selectivity, NVL-655 addresses key limitations of currently approved ALK inhibitors and has the potential to represent a distinct advancement as a fourth-generation inhibitor for patients with ALK-driven cancers.
Self-Reproduction and Evolution in Cellular Automata: 25 Years After Evoloops
Authors: Sayama Hiroki , Nehaniv Chrystopher L. 
Published: September 2024

Abstract
The year 2024 marks the 25th anniversary of the publication of evoloops, an evolutionary variant of Chris Langton’s self-reproducing loops, which proved constructively that Darwinian evolution of self-reproducing organisms by variation and natural selection is possible within deterministic cellular automata. Over the last few decades, this line of Artificial Life research has since undergone several important developments. Although it experienced a relative dormancy of activity for a while, the recent rise of interest in open-ended evolution and the success of continuous cellular automata models have brought researchers’ attention back to how to make spatiotemporal patterns self-reproduce and evolve within spatially distributed computational media. This article provides a review of the relevant literature on this topic over the past 25 years and highlights the major accomplishments made so far, the challenges being faced, and promising future research directions.
Digital Technologies and Atrocity Risks
Authors: Pawnday Savita 
Published: September 2024

Abstract
From a practitioner’s perspective the intervention explores how digital technologies have enhanced the capacities of policy-makers in anticipating and responding to atrocity crimes including through development and access to sophisticated technologies to collect and verify evidence of crimes for justice and accountability. Digital technologies have also provided perpetrators with enhanced tools to target populations with greater precision and commit atrocities against them. The intervention argues that the harm perpetuated by digital technologies can be mitigated by holding developers of these technologies accountable for creating operating environments that are safe and by naming and shaming governments that use new technologies to target populations.
Extinguishing the Fiery Skies: The History and Modern Prospects of Lightning Suppression within Thunderstorms
Authors: Stepanian Phillip M. , Williams Earle R. 
Published: September 2024

Abstract
It has been over 75 years since the concept of directly suppressing lightning by modifying thunderstorm cloud processes was first proposed as a technique for preventing wildfire ignitions. Subsequent decades produced a series of successful field campaigns that demonstrated several techniques for interrupting storm electrification, motivated in part by the prospect of protecting Apollo-era rocket launches from lightning strike. Despite the technical success of these research programs, funding and interest diminished until the final field experiment in 1975 marked the last large-scale activity toward developing lightning prevention technology. Having lost widespread awareness over the ensuing 50 years, these pioneering efforts in experimental cloud physics have largely been forgotten, and this approach for mitigating lightning hazards has fallen into obscurity. At the present day, risks from lightning-ignited wildfires to lives, property, and infrastructure are once again a major topic of concern. Similarly, the rapid development of an emerging commercial space sector is placing new demands on airspace management and launch scheduling. These modern challenges may potentially be addressed by a seemingly antiquated concept—lightning suppression—but considerations must be made to understand the consequences of deploying this technology. Nonetheless, the possible economic, environmental, and societal benefits of this approach merit a critical reevaluation of this hazard mitigation technology in the current era.
Hypophysitis and central nervous system involvement in association with Sjögren’s syndrome along with hypoparathyroidism: a case report
Authors: Yum Jungyon , Lee Sang-Won , Rhee Yumie , Heo Kyoung 
Published: September 2024

Abstract
Background
Patients with autoimmune diseases can develop multiple autoimmune diseases over a long period of time, and the presence of more than one autoimmune disease in a single patient is defined as polyautoimmunity. Polyautoimmunity may be clinical evidence that autoimmune diseases share similar immunological mechanisms.

Case presentation
We report a 30-year-old woman with a unique combination of autoimmune diseases predominantly affecting the central nervous system, with hypoparathyroidism, hypophysitis, medulla involvement, and pons and temporal lobe involvement associated with primary Sjögren's syndrome (pSS), occurring independently over a long period. The patient who had a history of muscle cramps and one seizure incident, presented with vomiting and blurred vision. She was diagnosed with hypophysitis and hypoparathyroidism with calcifications in the basal ganglia and cerebellum. She recovered after four months of corticosteroid treatment for hypophysitis and was started on treatment for hypoparathyroidism. Eight months later, she developed vomiting, hiccups, vertigo, and ataxia with a focal lesion in the medulla. She recovered with immunosuppressive treatment for 2 years. Fifty-eight months after the onset of hypophysitis, she developed diplopia and dry mouth and eyes. MRI showed infiltrative lesions in the left pons and left temporal lobe. Based on positive anti-Sjögren's syndrome-related antigen A antibodies and low unstimulated whole salivary flow rate, pSS was diagnosed. She received corticosteroids and continued mycophenolate mofetil treatment with recovery of neurological symptoms.

Conclusion
This case highlights the need for long-term follow-up to detect autoimmune disease processes involving various organs.
Navigating chronic uncertainty: a theory synthesis for nursing communication in life-limiting illness
Authors: Grant Julie B. , Johnson-Koenke Rachel 
Published: September 2024

Abstract
Background
Despite the proven benefits of early palliative care, patient communication regarding these services remains elusive. Therefore, this paper aims to (a) provide a focused literature review on nurse palliative care communication addressing chronic uncertainty in life-limiting illness (LLI), (b) define the Reconceptualization of Uncertainty in illness Theory and Problematic Integration Theory within a nursing Unitary Caring Science philosophical worldview and, (c) synthesize these theories and literature review into a unique theoretical framework for early palliative care communication in acute care nursing.

Method
Turner’s theory synthesis methodology was combined with a PRISMA-style literature review. The literature search was conducted in July 2023 and updated in May 2024 using EBSCOhost, Pubmed, and PsychINFO databases. A second literature search was undertaken to identify applicable uncertainty theories in chronic or LLIs.

Results
This theory synthesis highlights the interconnectedness of all facets of uncertainty for those living with severe LLI (personal factors, types of uncertainty, and the nursing communicatory process) and conceptualizes uncertainty communication as a series of events happening simultaneously, not simply a cause-and-effect process.

Discussion
The framework resulting from this synthesis encourages nurses’ holistic understanding of the complex nature of uncertainty in LLI, highlights the integral communicatory role nurses have in their patients’ health and wellness, and promotes further nursing-specific communication research. Future research on enabling nurse-initiated early palliative care communication and narrative communication techniques will support patients’ values and dignity throughout more than a single hospital stay but their entire disease trajectory.
Quality indicators for occupational therapy: a scoping review
Authors: Ballmer Thomas , Frey Sara , Petrig Andrea , Gantschnig Brigitte E. 
Published: September 2024

Abstract
Background
Occupational therapists are increasingly asked to demonstrate the effectiveness, appropriateness, and efficiency of their interventions to funding bodies. However, the extent to which this is practiced and the health policy context within which such a practice is situated differs internationally. The aim of this scoping review was to establish which quality indicators are used internationally for this purpose.

Methods
We conducted a scoping review, limiting our search to Europe and the English-speaking world. To search for suitable literature, we used specialized databases from medicine, health sciences, and related fields, including CINAHL Complete and MEDLINE, as well as free internet search via Google. Furthermore, we contacted national occupational therapy associations from several countries asking for access to documents found within this search that were only accessible to association members.

Results
The screening process identified 32 studies and documents from six national contexts. We identified and described process-level indicators, functional outcome indicators, one outcome indicator based on individual goal attainment (the Goal Attainment Scale, or GAS), and PRO-Ergo, a patient-reported experience measure (PREM). There was little information on the use of quality indicators to demonstrate the effectiveness, appropriateness, and efficiency of occupational therapy services to funding bodies in Europe and the English-speaking world that was openly available. The identified process indicators were in most cases not specific to occupational therapy interventions. Functional outcome indicators were highly specific to certain client groups or health conditions and partially appropriate for use in occupational therapy. The GAS was found to be a highly customizable measure which allowed an evaluation on body structure and function levels as well as activity and participation levels. PRO-Ergo was focused on the clients’ subjective view and their experience with occupational therapy interventions.

Conclusions
All identified quality indicators have advantages and disadvantages. Process-level indicators specific to occupational therapy could be a chance to foster the use of best practice methods. GAS and PRO-Ergo seem to be the most versatile assessment, allowing an evaluation on the level of activity and participation. Functional outcome indicators that cover a broad area of client problems may be useful additional quality indicators for some areas of practice.
Patient-reported outcome measures for acute rhinosinusitis in adults and children: a systematic review of the quality of existing instruments
Authors: Baalmann Ann-Kristin , Nestler Sophie , Donhauser Theresa , Apfelbacher Christian , Piontek Katharina 
Published: September 2024

Abstract
Background
Acute rhinosinusitis (ARS) is a self-limiting inflammation of the nose and sinuses caused by viral or bacterial infections that requires primarily symptomatic treatment. Patient-reported outcome measures (PROMs) are suitable tools for the assessment of the effectiveness of remedies for ARS from the patient’s perspective in clinical trials and real-world studies. Data regarding the quality of existing PROMs for ARS are limited.

Purpose
To conduct a systematic review of the quality of existing disease-specific PROMs for use in adults and children with ARS according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology, and to derive recommendations for use of the identified instruments in future clinical studies.

Methods
We systematically searched PubMed, Web of Science and Embase for studies reporting on the development and/or validation of PROMs for ARS. We assessed the methodological quality of each included study, evaluated the quality of measurement properties per PROM and study, and graded the evidence. Based on the overall evidence, we derived recommendations for use of the instruments.

Results
We identified four studies on three PROMs measuring symptoms of ARS and quality of life in adults (Sinonasal Outcome Test-16, SNOT-16; Measurement of Acute Rhinosinusitis, MARS; Rhinosinusitis Quality-of-Life Assessment, RhinoQoL). For ARS in children, we identified two studies on two PROMs measuring symptoms of ARS (Pediatric Rhinosinusitis Symptom Scale, PRSS; Sinus Symptom Questionnaire, S5). Our assessment of measurement properties indicates that all instruments require further validation before they can be unrestrictedly recommended for use in future research (COSMIN category B). In particular, there were no content validity studies for any of the identified instruments, but also data on other important measurement properties, e.g., structural validity, are lacking.

Conclusion
Currently, no PROM for ARS in adults and children can be unrestrictedly recommended based on the evaluation of their quality. Further validation is required for all identified PROMs. Content validation involving patients and experts should be given priority.

Systematic review registration
OSF (https://doi.org/10.17605/OSF.IO/VAP8U).