bluuebunny/crossref_metadata_2025_split huggingface dataset:
PH‐Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2‐Propionic‐3‐Methyl‐maleic Anhydrides with Cholesteryl End Groups
Authors: Heck Alina G. , Medina‐Montano Carolina , Zhong Zifu , Deswarte Kim , Eigen Katharina , Stickdorn Judith , Kockelmann Johannes , Scherger Maximilian , Sanders Niek N. , Lienenklaus Stefan , Lambrecht Bart N. , Grabbe Stephan , De Geest Bruno G. , Nuhn Lutz 
Published: September 2024

AbstractGaining spatial control over innate immune activation is of great relevance during vaccine delivery and anticancer therapy, where one aims at activating immune cells at draining lymphoid tissue while avoiding systemic off‐target innate immune activation. Lipid‐polymer amphiphiles show high tendency to drain to lymphoid tissue upon local administration. Here, pH‐sensitive, cholesteryl end group functionalized polymers as stimuli‐responsive carriers are introduced for controlled immunoactivation of draining lymph nodes. Methacrylamide‐based monomers bearing pendant 2‐propionic‐3‐methylmaleic anhydride groups are polymerized by Reversible Addition‐Fragmentation Chain Transfer (RAFT) polymerization using a cholesterol chain‐transfer agent (chol‐CTA). The amine‐reactive anhydrides are conjugated with various amines, however, while primary amines afforded irreversible imides, secondary amines provided pH‐responsive conjugates that are released upon acidification. This can be applied to fluorescent dyes for irreversibly carrier labeling or immunostimulatory Toll‐like receptor (TLR) 7/8 agonists as cargos for pH‐responsive delivery. Hydrophilization of remaining anhydride repeating units with short PEG‐chains yielded cholesteryl‐polymer amphiphiles that showed efficient cellular uptake and increased drug release at endosomal pH. Moreover, reversibly conjugated TLR 7/8 agonist amphiphiles efficiently drained to lymph nodes and increased the number of effectively maturated antigen‐presenting cells after subcutaneous injection in vivo. Consequently, cholesteryl‐linked methacrylamide‐based polymers with pH‐sensitive 2‐propionic‐3‐methylmaleic anhydride side groups provide ideal features for immunodrug delivery.
Microlens Encapsulation of Thixotropic Siloxane/Silica Nanocomposites for Highly Efficient and Reliable Micro‐Light‐Emitting Diodes
Authors: Um Byung Jo , Kweon Hyungshin , Joo Jiho , Kang Seung‐Mo , Kim Seungwan , Choi Gwang‐Mun , Lee Chanmi , Eom Yong Sung , Choi Kwang‐Seong , Jang Junho , Bae Byeong‐Soo 
Published: September 2024

AbstractEncapsulating materials for light‐emitting diodes (LEDs) with optical‐grade polymeric resin is essential to protect from external environments and to improve light‐extraction efficiency (LEE) in micro‐scale LED (µ‐LED). In addition, the formation of microlens can further enhance the optical performance of µ‐LED. However, previously developed materials have limitations due to a lack of rheological properties and thermal stability. Here, the fabrication of sol–gel derived phenyl siloxane hybrid (PSH) that has a high refractive index (n), for use as an encapsulating material for µ‐LEDs is reported. Fumed silica nanoparticles (FSNs) are mixed with the PSH to yield siloxane/silica nanocomposites that have thixotropic properties, which enable the formation of microlens arrays. Optimizing the concentration of FSN in the nanocomposites yields a siloxane/silica nanocomposite that has a high n = 1.590 at 486 nm, high thixotropic index = 3.956, and increased optical haze (79.83% at 550 nm) makes light scattering. The use of PSH significantly increases the LEE of the LED (124.6% increase compared to an LED that does not use it). Finally, the siloxane/silica nanocomposite is used to direct‐dispense microlenses on µ‐LEDs in arrays. The encapsulation strategy can increase both the LEE and reliability of µ‐LEDs.
Net Zero Energy‐Ready Buildings: A Canadian Construction Perspective and Evaluation
Authors: Mohammed Noushad Ahamed Chittoor , Grewal Kuljeet Singh , Adesanya Misbaudeen Aderemi , Debnath Sudipta , Farooque Aitazaz A. , Selopal Gurpreet Singh 
Published: September 2024

AbstractTo attain net zero energy‐ready building (NZErB) status, various research efforts have focused on identifying potential strategies and creating stringent code compliances for builders. This review presents a comparative assessment of Canadian newly constructed, retrofitted, and potential retrofit buildings from the mid‐1900s to 1990, all aiming for NZErB status. 22 case studies from climate zones 5, 6, and 7a are evaluated, including 12 new constructions and 4 retrofitted, and 6 potential retrofit buildings. A life cycle assessment (LCA) analysis is conducted to understand the environmental impacts of different insulation materials. Additionally, this review highlights retrofitted buildings measures toward climate resilience, challenges inretrofitting, andstrategies for achieving high‐quality retrofits. The work concluded that 83.3% of new buildings achieved level 5 in thermal energy demand intensity (TEDI), while 70% of completed and potential retrofits reached level 5 in mechanical energy usage intensity (MEUI). Cellulose insulation showed the lowest global warming potential (GWP) at 12.07 kg CO₂‐e·m−3. By comparing the performance of new constructions with completed and potential retrofits, this review provides valuable insights into the feasibility and effectiveness of retrofitting older buildings to attain net zero energy readiness.
Strong Electron Coupling Effect of Prussian Blue Analogs Derived Ultrathin Nitrogen‐Doped Carbon Wrapped Fe‐CoP for Enhanced Wide Spectrum Photocatalytic H2 Evolution
Authors: Jing Jiejie , Wang Xue , Hao Xuqiang , Jin Zhiliang 
Published: September 2024

AbstractWith the advantages of large specific surface area and high porosity of general metal‐organic frame materials, russian blue analogs have broad application prospects in catalysis. In this work, a series of ultra‐thin N‐doped carbon coated Fe‐CoP (Fe‐CoP@NC) are prepared by phosphating Fe‐Co‐Co Prussian blue analogs (Fe‐Co‐Co PBA) in different degrees for the broad‐spectrum photocatalytic hydrogen evolution. The results show that Fe‐CoP@NC‐3 has the highest photocatalytic hydrogen production rate of 16.6 mmol h−1 g−1, which is 83 times greater than that of Fe‐Co‐Co PBA. The excellent stability of Fe‐CoP@NC‐3 is proved by cyclic experiments. The outstanding photocatalytic H2 production activity of Fe‐CoP@NC‐3 can be ascribed to the strong electron coupling effect between Fe‐CoP and N‐doped carbon layer. The photogenerated electrons of Fe‐CoP are transferred to the N‐doped carbon layer, which is electron transport mediator accelerating the electron transfer and synergetic improving the hydrogen evolution efficiency. This work provides an effective strategy for designing an ultra‐thin N‐doped carbon layer coated phosphide photocatalyst with strong electron coupling effect.
Drug Discovery and Screening Tool Development for Tauopathies by Focusing on Pathogenic Tau Repeat 3 Oligomers
Authors: Yoon Soljee , Kim Hye Yun , Park Sohui , Cha Minhae , Kim Kyeonghwan , Lee Songmin , Kim JiMin , Bhang Saeyun , Kim YoungSoo 
Published: September 2024

AbstractComprehending early amyloidogenesis is essential for the development of effective therapeutic strategies. In tauopathies like Alzheimer's disease (AD), the abnormal accumulation of tau protein is initiated by pathological tau seeds. Mounting evidence implies that the microtubule binding domain, consisting of three to four repeats, plays a pivotal role in this process, yet the exact region driving the formation of pathogenic species needs to be further scrutinized. Here, we chemically synthesized individual tau repeats to identify those exhibiting pathogenic prion‐like characteristics. Notably, repeat 3 (R3) displayed a remarkable propensity to polymerize, form toxic filaments, and induce cognitive impairment, even in the absence of an aggregation‐promoting inducer, highlighting its physiological relevance. Additionally, oligomeric R3 was identified as a particularly pathological form, prompting the establishment of a screening platform. Through screening, tolcapone was found to possess therapeutic efficacy against pathological tau aggregates in PS19 transgenic mice. This screening platform provides a valuable avenue for identifying compounds that selectively interact with peptides implicated in the progression of tauopathies.
A Novel ⋅OH‐Monitor ER‐Targeted Probe to Expose the Function of Sorafenib
Authors: Kong Lingyu , Zhao Manfen , Zhu Xiaofei , Liu Jianfei , Zhang Di , Ye Yong 
Published: September 2024

AbstractThe hydroxyl radical (⋅OH), widely recognized as the most potent free radical, plays a crucial role in numerous physiological and pathological pathways due to its strong oxidizability.Ferroptosis, as a novel mode of cell death, is initiated by the accumulation of iron‐dependent lipid peroxidation. Among them, ⋅OH as the original reactive oxygen species (ROSs)is mass‐produced due to Fenton reaction in vivo and closely related to cancer treatment.Besides, endoplasmic reticulum (ER) as a membrane‐rich structure organelle, is a crucial organelle in all eukaryotes where excessive expression of ROSs, including ⋅OH can triggerER stress which was reported thatwasclosely related toferroptosis. So developing a new probe for their interrelationship research is important. In this paper, we constructed a1,8‐naphthalimide‐based ER‐targeted fluorescence probe named M‐1 to monitor ⋅OH variation in vitro and vivo. What's more, we achieved the monitor of ⋅OH during ER stress andferroptosis processesin cancer cells, andfurther explored the important role of ER stress and ferroptosis processes in SF (sorafenib) involved cancer cells.
How the persuasiveness of statistical evidence compared to personal testimonials depends on the recipient's distance from the message issue
Authors: Wieluch Marina I. , Praxmarer‐Carus Sandra 
Published: September 2024

AbstractStatistical facts and personal testimonials (anecdotal evidence) are two common types of evidence used in health education, warning messages, and charitable appeals. While statistical evidence provides aggregated numerical information, messages that use anecdotal evidence typically describe an individual experience. Because research has not found a stable advantage of one type of evidence over the other, the literature has sought to identify moderators that predict when statistical or anecdotal evidence is more persuasive. This paper shows that the relative persuasiveness of statistical versus anecdotal evidence depends on the psychological distance between the message recipient and the message issue. An increase (decrease) in recipients' message‐issue distance increases the relative persuasiveness of statistical (anecdotal) evidence. In addition, we show that message‐issue distance determines how personally useful message recipients find statistical and anecdotal evidence. We also demonstrate that recipients' more abstract (concrete) thinking about the message issue prior to message exposure increases the persuasiveness of statistical (anecdotal) evidence. Based on our findings, we recommend that social marketers use statistical (anecdotal) evidence when the recipients' distance from the message issue is high (low) and the recipients' thinking about the message issue is abstract (concrete). Before deciding on the type of evidence, message designers may need to assess how abstract or concrete their target audience thinks about the message issue. The short measure used in Experiment 1b of this paper may be useful. It is adaptable to different message contexts and could easily be implemented in pretests to decide when to use statistical or anecdotal evidence.
Substrate‐Multiplexed Assessment of Aromatic Prenyltransferase Activity
Authors: Higgins Peyton M. , Wehrli Nicolette G. , Buller Andrew R. 
Published: September 2024

AbstractAn increasingly effective strategy to identify synthetically useful enzymes is to sample the diversity already present in Nature. Here, we construct and assay a panel of phylogenetically diverse aromatic prenyltransferases (PTs). These enzymes catalyze a variety of C−C bond forming reactions in natural product biosynthesis and are emerging as tools for synthetic chemistry and biology. Homolog screening was further empowered through substrate‐multiplexed screening, which provides direct information on enzyme specificity. We perform a head‐to‐head assessment of the model members of the PT family and further identify homologs with divergent sequences that rival these superb enzymes. This effort revealed the first bacterial O−Tyr PT and, together, provide valuable benchmarking for future synthetic applications of PTs.
Magnetic Nanoparticles and Radio Frequency Induction: From Specific Heating to Magnetically Induced Catalysis
Authors: Mazarío Jaime , Ghosh Sourav , Varela‐Izquierdo Víctor , Martínez‐Prieto Luis M. , Chaudret Bruno 
Published: September 2024

AbstractThis comprehensive review explores the potential of radio frequency (RF) induction heating in chemical reactions, explicitly focusing on magnetically induced catalysis using magnetic nanoparticles (NPs). We trace the recent historical progress of induction heating and highlight the advancements in liquid and gas‐phase reactions, particularly in its integration with heterogeneous catalysis. The review finds that induction heating profoundly impacts reaction kinetics, and selectivity, and can even reduce overpotentials in electrocatalytic processes. A final outlook unveils the challenges and opportunities associated with aspects such as fundamental research and reactor design, with a particular focus on expanding its use to higher pressures and necessary optimizations to improve energy efficiency. Moreover, it highlights the pressing need for standardized reporting in induction‐heated catalysis. The study underscores the significance of this brand‐new field in developing efficient and sustainable catalytic processes, which are essential for meeting the growing demand for clean energy and sustainable chemical production.
Engineering of Active Sites in Metal‐Organic Frameworks for Friedel–Crafts Alkylation
Authors: Lawrence Arputham Shophia , Sivakumar Balasubramanian , Rokhum Samuel Lalthazuala , Biswas Shyam , Cirujano Francisco G. , Dhakshinamoorthy Amarajothi 
Published: September 2024

AbstractFriedel–Crafts alkylation reaction is one of the C─C bond forming reactions catalyzed by homogeneous or heterogeneous catalysts possessing Lewis and Bronsted acids. Metal organic frameworks (MOFs) with Lewis acid/Bronsted acid sites or hydrogen bonding donor sites are potential catalysts to promote the widely employed Friedel–Crafts alkylation to form C─C bonds between arenes and electron‐poor olefins, alcohols, or alkyl bromides. Such acid‐active sites are present either at the organic linkers or inorganic clusters of the crystalline porous framework, resulting in well‐dispersed heterogeneous active sites able to compete with well‐established homogeneous minerals and organocatalysts. The available literature data are grouped based on the nature of active sites. Whenever possible, the comparison of the activity of MOFs with other heterogeneous and homogeneous catalysts is provided to illustrate the possible benefits of MOFs compared to other catalysts. The concluding section provides our views and future developments in this field.
H/D Isotope Effects in the Electrochemistry of Electrochromic Iron Hexacyanoruthenate
Authors: Gerhards Lena , Brand Izabella , Wittstock Gunther 
Published: September 2024

AbstractThe electrochemical deposition of iron hexacyanoruthenate (Fe−HCR) on gold electrodes was studied in electrolytes prepared with light and heavy water. Cyclic voltammetry of the material during preparation and after transfer to a precursor‐free solution exhibits two reductions peaks in H2O‐based electrolytes but only one reduction peak in D2O‐based electrolytes. The voltammetric behavior changes reversibly upon transfer of the material between D2O‐based and H2O‐based 1 mol L−1 KCl solutions. No clear structural differences between samples prepared in D2O and H2O were detected by means of X‐ray photoelectron spectroscopy (XPS) and polarization modulation infrared reflection absorption spectroscopy (PM IRRAS). We noted a relatively slow exchange of coordinated water and a fast exchange of zeolitic water. Using voltammetric experiments we could rule out simple effects of solution conductivity for K+, participation of H+/D+ in the charge compensation and surface effects on the observed dependence of the peak splitting on the isotopic composition of the solvent. The most likely reason for the observed behavior is the different structure of the H‐bonded water network of coordinated H2O and zeolitic H2O/D2O which is supported by the PM IRRAS data.
A Novel Banana‐Shaped Mixed‐Metal Co/Fe Polyoxometalate Cluster
Authors: Quirós‐Huerta Javier , Troya José , Clemente‐León Miguel , Clemente‐Juan Juan Modesto , Coronado Eugenio , Soriano‐López Joaquín 
Published: September 2024

AbstractThe synthesis and characterization of a Co/Fe mixed‐metal banana‐shaped polyoxometalate with the formula [(Co2.5Fe0.5(H2O)PW9O34)2(PW6O26)]16− (Co5Fe) is reported. This transition‐metal‐substituted polyoxometalate readily assembles from its components in a one‐pot reaction and crystallizes in the monoclinic space group P21/c. The structure of Co5Fe can be considered a double sandwich composed by two B‐α‐{Co2.5Fe0.5PW9O40} Keggin units, in which one coordinatively saturated octahedral metal position is equally occupied by Co(II) and Fe(III) ions with a 50 % of site occupancy. These Keggin units are linked via a hexalacunary Keggin unit {PW6O26}. Single crystal X‐ray diffraction and magnetic measurements support the proposed atom arrangement within the crystal structure. Magnetic measurements of these double trimeric unit {Co2.5Fe0.5O13}2 show a combination of antiferromagnetic interactions, the presence of spin frustration, and the first‐order spin‐orbit coupling of Co(II) ions. Electrocatalytic water oxidation measurements show that Co5Fe displays low stability in both homogeneous and heterogeneous conditions. This is evidenced by the constant increase on the catalytic currents over time together with the appearance of polyoxometalate‐derived electrode‐bound species that can be responsible for the observed catalytic activity.
Challenges and Modification Strategies on High‐Voltage Layered Oxide Cathode for Sodium‐Ion Batteries
Authors: Li Yuesen , Zhang Tong , Song Zihao , Huang Yaohui , Li Fei , Chen Aibing , Li Fujun 
Published: September 2024

AbstractSodium‐ion batteries (SIBs) have attracted great attention due to their advantages on resource abundance, cost and safety. Layered oxide cathodes (LOCs) of SIBs possess high theoretical capacity, facile synthesis and low cost, and are promising candidates for large scale energy storage application. Increasing operating voltage is an effective strategy to achieve higher specific capacity and also high energy density of SIBs. However, at high operating voltages, LOCs will undergo a series of phase transitions in bulk phase, leading to huge change of volume and layer spacings accompanied by severe lattice stress and cracking formation. Degeneration of surface also occurs between LOCs and electrolytes, resulting in sustained growth of cathode electrolyte interphase (CEI) and release of O2 and CO2. These induce structural destruction and electrochemical performance degradation in high voltage regions. Recently, many strategies have been proposed to improve electrochemical performance of LOCs under high voltages, including bulk element doping, structural design, surface coating and gradient doping. This review describes pivotal challenges and occurrence mechanisms at high voltages, and summarizes strategies to improve stability of bulk and surface. Viewpoints will be provided to promote development of high energy density SIBs.
One‐Pot, Solvent Free Synthesis of 2,5‐Furandicarboxylic Acid from Deep Eutectic Mixtures of Sugars as Mediated by Bifunctional Catalyst
Authors: Niakan Mahsa , Qian Chao , Zhou Shaodong 
Published: September 2024

AbstractCurrently one‐pot conversion of sugars to 2,5‐furandicarboxylic acid (FDCA) is of significant interest due to the attainability of sugars as a feedstock and the enormous potential of FDCA as a bioplastic monomer. However, it remains challenging to construct efficient catalysts for this process. In this study, Co3O4 species were anchored to a sulfonated covalent organic framework thus affording a bifunctional catalyst (Co3O4@COF‐SO3H). The sulfonic acid sites dehydrate sugars to 5‐hydroxymethylfurfural (HMF), which is next oxidized to FDCA as catalyzed by the Co3O4 species. Such a process was applied in the conversion of various binary and ternary deep eutectic mixtures involving choline chloride and sugars without additional solvent. The maximum FDCA yield of 84 % was obtained using glucose‐fructose eutectic mixture as the substrates. Moreover, the catalyst was recyclable and stable under the applied reaction conditions. Our process eliminates the employment of organic solvents and expensive noble metal catalysts, resulting in green and economic biomass conversions.
Understanding the social and emotional domains of physical literacy in post‐secondary education: A scoping review
Authors: Van Wyk Nadine , Lafave Mark , Lafave Lynne , Eubank Breda , Clark Marty , Christiansen Erik 
Published: September 2024

AbstractWhile a variety of definitions persist, a common definition of physical literacy is that it encompasses the motivation, confidence, physical competence, knowledge and understanding to value and take responsibility for engagement in physical activities over the lifespan. While this perspective to physical literacy is broad, a great deal of curricular outcomes still focus on the physical competence, knowledge and understanding aspects of the framework leaving a gap in the holistic nature of the construct. This scoping review explores the construct of physical literacy within post‐secondary education, focusing on how social and emotional dimensions are integrated in teaching, delivery and assessment. This scoping review followed PRISMA‐ScR guidelines. Five online databases were used to identify papers published that used physical literacy in combination with post‐secondary as the educational setting with a focus on curriculum. The findings underscore a substantial gap in the literature. It was identified that the physical aspects of physical literacy were predominant with limited attention to the social and emotional domains. The gap implies that the comprehensive construct of physical literacy, which encompasses non‐physical facets, is often omitted in post‐secondary curricula. The review highlights an unexplored opportunity for post‐secondary institutions to intentionally construct more comprehensive physical literacy programmes. By incorporating social and emotional dimensions into these programmes, students gain a more holistic understanding of physical literacy. Subsequent research can delve into effective integration strategies and the potential benefits of such an approach.