bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reviving the poppy seed test for the diagnosis of colovesical fistula: A case report from a single rural center experience
Authors: Le Khang Duy Ricky , Haycock Shasha , Wang Annie Jiao , Yeaman Leslie 
Published: October 2024

Key Clinical MessageThe poppy seed test is a valuable, cost‐effective, and sensitive initial diagnostic investigation to identify the presence of colovesical fistula, particularly for clinicians in remote or rural areas with lack of access to specialist radiologic, endoscopic, surgical, or urological support. The poppy seed test therefore may act as a bridge toward the commencement of appropriate referral pathways for the management of colovesical fistula.AbstractThe diagnosis of colovesical fistula is resource intensive, often requiring a combination of radiological investigation and endoscopy. The poppy seed test is a non‐invasive and cost‐effective alternative that has been demonstrated to identify presence of colovesical fistula with high sensitivity. There is however a noticeable paucity of recommendations for the poppy seed test in the diagnostic approach to colovesical fistula due to significant advancements in alternative radiologic and endoscopic technologies. Despite this, in resource‐challenged areas with lack of specialist support, the poppy seed test is a cost‐effective, accessible and safe test that can be performed to confirm the presence of colovesical fistula. We report a case of a 79‐year‐old man with a past history of colorectal cancer managed surgically with adjuvant chemoradiotherapy who develops noisy micturition, pneumaturia, and fecaluria 22 years after treatment. Given the suspicion of colovesical fistula, computed tomography imaging and cystoscopy were performed which was unable to demonstrate an overt fistula. The poppy seed test was utilized and demonstrated presence of poppy seeds in the urine, confirming the presence of a fistula. The patient was referred to a specialist surgical center for consideration of further management. The poppy seed test is a valuable initial diagnostic investigation for clinicians in remote or rural areas with lack of access to specialist radiologic, endoscopic, surgical, or urological support in confirming the presence of a colovesical fistula and initiating referral pathways for the management of this condition.
A rare case of a 5‐year‐old girl with Klippel–Trénaunay syndrome and a bleeding focal vulvar hemangioma in Uganda
Authors: Peter Mundeli Simon , Gibu Sibali Gidimali , Kizito Mirembe Stephen 
Published: October 2024

Key Clinical MessageKlippel–Trénaunay syndrome can present with atypical manifestations such as a bleeding vulvar hemangioma. This case report, the first documented in Uganda, highlights the need for awareness of such presentations and underscores the importance of continuous follow‐up in female patients to manage potential complications throughout adolescence and pregnancy.AbstractKlippel–Trénaunay syndrome (KTS) is a rare congenital disorder marked by bone and soft tissue hypertrophy, port‐wine stains, and varicosities. Cases involving genital hemangiomas are rare. This report highlights a 5‐year‐old girl in Uganda with typical KTS features, including hypertrophy and port‐wine stains, along with a bleeding vulvar hemangioma, emphasizing its uncommon presentation and potential complications. Treatment involved compression bandaging and timolol 0.2% solution. This case underscores the importance of awareness of atypical manifestations of hemangiomas with KTS and continuous follow‐up for female patients, especially through adolescence and pregnancy, due to potential complications such as prepubertal per vaginal bleeding, menorrhagia, and post‐partum bleeding.
Reaction kinetics of molybdenum dissolution by hydrogen peroxide in acidic and alkaline solutions using tartaric acid and sodium hydroxide: A semi‐empirical model with rotating disc method
Authors: Motasim Mahmoud , Agacayak Tevfik , Eker Yasin Ramazan , Aydogan Salih , Abbaker Ahmed 
Published: October 2024

AbstractMolybdenum is an amphoteric metal that dissolves in both acidic and alkaline solutions. This fundamental study explores a sustainable process for the dissolution of molybdenum, focusing on the reaction kinetics in H2O2, H2O2‐NaOH, and H2O2‐C4H6O6 solutions. A rotating disc method was applied with the Levich's equation. Semi‐empirical models with activation energy were developed for the H2O2‐NaOH and H2O2‐C4H6O6 solutions. The study examined the effects of rotating speed, disc surface area, temperature, H2O2, NaOH, and C4H6O6 concentrations, along with rotating speed, disc surface area, and temperature. Hydrogen peroxide significantly impacted molybdenum dissolution rates across all three solutions. The reaction order of hydrogen peroxide concentration in the H2O2 solution was greater than that of the H2O2‐NaOH and H2O2‐C4H6O6 solutions. The complex of molybdenum peroxo was formed in H2O2 and H2O2‐NaOH solutions but decomposed at a temperature ≥50°C. The activation energies were determined to be 49.90, 43.60, and 41.10 kJ/mol for the H2O2, H2O2‐NaOH, and H2O2‐C4H6O6 solutions.
Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy
Authors: Wang Richard , Sacknovitz Ariel , Vazquez Sima , Dominguez Jose , McGoldrick Patty , Wolf Steven , Sukul Vishad , Muh Carrie , Patra Sanjay E. , Burdette David E. 
Published: October 2024

AbstractObjectiveTo describe four cases of Responsive Neurostimulation (RNS) in the bilateral pulvinar nuclei (PUL) in individuals with drug resistant epilepsy (DRE). This will show that due to widespread PUL connectivity, bilateral PUL RNS may be an option for some individuals with bilateral multifocal epilepsy.MethodsThis study comprises two centers' experience with bilateral PUL RNS for DRE. Patients treated with bilateral PUL RNS at Westchester Medical Center (Valhalla, NY) and Corewell Health (Grand Rapids, MI) between the years 2019 and 2022 were analyzed and described. Presented here are methods for target selection, device programming, and clinical outcomes.ResultsTwo patients with Lennox–Gastaut phenotype (aged 13 and 21 years) with posteriorly dominant discharges were implanted with bilateral PUL electrodes. Additionally, two patients (aged 20 and 31 years) with independent left and right occipital bilateral multifocal seizure onsets were implanted with bilateral RNS devices targeting the ipsilateral PUL and ipsilateral occipital cortex. Subclinical and clinical seizures were captured by RNS electrocorticography (ECoG) in all patients. RNS implantation and treatment was well‐tolerated without adverse effects in all patients. Relative to baseline, two patients had 25% and 50% reduction in disabling seizures, and two patients had 71% and 100% reduction in disabling seizures. Stimulation paradigms utilized high frequency stimulation in both Lennox–Gastaut phenotype patients. Low frequency (individualized to the terminal ictal frequencies) stimulation was effective in the two bioccipital patients.SignificanceRNS with electrode placement targeting bilateral PUL is safe, and no adverse effects have been attributable to the pulvinar electrode placement. PUL responsive neurostimulation is potentially effective for patients with bilateral multifocal, posteriorly dominant DRE. Both high and low frequency responsive stimulation are treatment options. Longer follow‐up will shed light on the ultimate reduction of seizure burden.Plain Language SummaryWe describe four cases where stimulation devices were placed in the Pulvinar area of the thalamus (central sensory area in the brain). This is very unique and different location than where these devices are typically placed. These patients all had great outcomes with marked seizure reduction, demonstrating that this placement is both safe and effective.
PS‐InSAR post‐processing for assessing the spatio‐temporal differential kinematics of complex landslide systems: A case study of DeBeque Canyon Landslide (Colorado, USA)
Authors: Zocchi Marta , Delchiaro Michele , Troiani Francesco , Scarascia Mugnozza Gabriele , Mazzanti Paolo 
Published: October 2024

AbstractThe complex superimposition of different kinematics and nested sectors within landslide systems amplifies the challenge of interpreting their heterogeneous displacement pattern and targeting effective mitigation solutions. As an example of such peculiar spatio‐temporal behaviour, the DeBeque Canyon Landslide (Colorado, USA) is emblematic of the application of interferometric post‐processing analysis for a detailed, remotely‐based investigation. We employed a multi‐geometry Persistent Scatterers (PS) InSAR dataset to provide continuous information on the spatio‐temporal scale and achieve a solid representation of the segmented kinematics and timings. Using an updated geomorphological map of the landslide system, we performed a two‐dimensional decomposition of the Persistent Scatterers (PS) dataset to determine the displacement orientation and inclination for each internal sector of the landslide system. We then conducted statistical analyses on the displacement vector characteristics and time series data. These analyses enabled us to spatially characterize the segmented activity patterns of the landslide system and identify abrupt changes in trends associated with preparatory and triggering factors. A clear differentiation of the rotational or translational kinematics within the landslide system was accomplished solely using surface displacement measures. Moreover, the application of a Bayesian model on the bi‐dimensional vector time series leads to the identification of significant differences in the deformational behaviour of each sector with respect to precipitation and temperature factors. Our approach represents a replicable method for local‐scale characterization and monitoring of landslides exhibiting complex spatio‐temporal displacement patterns and providing an effective, low‐cost solution for transportation agencies from a risk‐reduction perspective.
MiR‐149‐5p in Tfh Cell‐Derived Exosomes Promotes B Cell Proliferation and Maturation Through the Wnt3a/Axin2 Axis in Allergic Rhinitis
Authors: Cao Xue , Gao Xiaochen , Dong Yuhan , Liu Chengcheng , Li Xiaoming , Qi Wenwen , Yuan Fanyu , Li Chengzhilin , Zhao Xuening , Xia Ming 
Published: October 2024

ABSTRACTAllergic rhinitis (AR) is one of the most frequently observed diseases in otorhinolaryngology, a global issue that alters the quality of life of patients. Both B cells and follicular helper T cells (Tfhs) have important roles in allergic diseases. However, how Tfhs and B cells interact to modulate allergic rhinitis pathogenesis remains unclear. In this study, two models of allergic rhinitis were examined, including the co‐culture of follicular helper T cells (Tfhs) isolated from mouse spleen with B cells. To further define the mechanism, exosomes from Tfh cells were isolated and added to B cells. Bulk RNA sequencing (RNA‐seq) analysis was used to compare exosomes derived from Tfhs cells in a mouse model of allergic rhinitis and exosomes derived from Tfhs cells in wild‐type mice. Among them, miR‐149‐5p was observed to be lowly expressed in the allergic rhinitis group, which was confirmed using qPCR. miR‐149‐5p mimics or inhibitors were utilised to overexpress or knock down miR‐149‐5p in Tfhs, which were then co‐cultured with B cells, demonstrating that miR‐149‐5p is negatively correlated with B cell proliferation and maturation. The function of WNT3A, a target gene of miR‐149‐5p, and the downstream effector AXIN2 on the proliferation and maturation of B cells were predicted and verified. We show that miR‐149‐5p packaged in Tfhs‐derived exosomes induces B cell proliferation and maturation through the WNT3A/AXIN2 axis. The discovery will contribute to new ideas for the treatment of allergic rhinitis.
Indian hidden tuber “Ram Kand Mool” (Maerua oblongifolia A. Rich): Cultivation, phytochemistry and potential applications—A comprehensive review
Authors: Singh Poornima , Singh Anurag 
Published: October 2024

AbstractRam Kand Mool (Maerua oblongifolia A. Rich) is a little tree or shrub. It grows easily from seed or cuttings and requires minimal care. The leaves and roots of Maerua oblongifolia A. Rich have most commonly been used for ages. This shrub has a mythological importance in Indian beliefs. Maerua oblongifolia A. Rich has many ethnobotanical uses. Maerua oblongifolia A. Rich contains various phytochemicals, including terpenoids, flavonoids, phenolic acids, and alkaloids. These phytochemicals have antioxidant, anti‐inflammatory, antibacterial, and anticancer properties. Traditional medical practices use it to treat inflammation, pain, infections, skin diseases, and gastrointestinal concerns. Maerua oblongifolia A. Rich may be used in pharmaceutical, nutritional, and personal care products. It is useful in the kitchen, medical cabinet, and cosmetics sector. The information compiled indicates that Ram Kand Mool has enormous potential for utilization as a functional food and various other value‐added products. Pre‐treatments are needed to remove the anti‐nutritional factors present in it. This article describes the nutritional and medicinal benefits of Maerua oblongifolia A. Rich in detail. The information about the medicinal usage of Ram Kand Mool in traditional medical practices and nutritional benefits have been comprehensively compiled in this article.
Serpentinised Dunites of the Neoarchean Shimoga Greenstone Belt, Western Dharwar Craton, India: Insights on Ni‐PGE Mineralisation and Genesis
Authors: Dhanakumar Singh Th. , Manikyamba C. , Harshitha G. , Lingadevaru M. , Subramanyam K. S. V. , Pahari Arijit 
Published: October 2024

ABSTRACTUltramafic rocks of the Archean greenstone belts worldwide are potential hosts for Cu‐Ni, precious metal deposits like platinum group elements (PGEs) and gold. This study highlights the geochemical evidence and genesis of Ni‐PGE mineralisation in the ultramafic rocks of Shimoga greenstone belt of the Western Dharwar Craton, India. Petrographically, the studied rocks are identified to be serpentinised dunites, while their geochemical signatures indicate komatiitic affinity. Presence of disseminated sulphides and pronounced serpentinisation in these rocks suggest a combination of Type II (disseminated sulphides) and Type IV (post‐magmatic alterations) komatiite‐related Ni–Cu‐PGE deposits. Chondritic Al2O3/TiO2 (9.65–16.38) ratios, superchondritic Gd/YbN (1.3–1.6), depleted high‐field‐strength elements (HFSEs) (Zr, Hf), enrichment of LREE over HREE and negative Nb–Ta anomalies reflect the generation of parental melts from plume‐sourced Al‐depleted komatiites with significant crustal contamination during their emplacement. The major, trace element and PGE relationships (FeO vs. MgO, Cu vs. Pd, Ni/Cu vs. Pd/Ir) infer the origin of sulphur undersaturated primary melts through moderate to higher degrees of partial melting followed by crustal assimilation that led to PGE enrichment. These observations suggest their formation from melts derived from greater depths of the upper mantle (> 400 km) at high pressure (> 10 GPa), wherein, the mantle residue retained majorite garnet. The high Ni (avg. Ni = 6511 ppm) substantiated by high Kambalda ratio ([Ni:Cr] × [Cu:Zn] = 5.6), Ni/Cr ratios (> 1) with high concentration of PGEs (avg. ∑PGE = 3078 ppb) confirm the fertile/mineralised nature of the komatiitic source and potential Ni‐PGE mineralization in the ultramafic rocks of the Shimoga greenstone belt.
Optimising Neural Networks for Enhanced Fracture Density Prediction in Surrounding Rock of Coalbed Methane Reservoir
Authors: Men Xinyang , Chen Shida , Wu Heng , Zhang Bin , Zhang Yafei , Tao Shu 
Published: October 2024

ABSTRACTFractures influence the mechanical strength of coal roof and floor, constraining the design of hydraulic fracturing for coalbed methane production. Currently, the predominant approach involves the integration of petrophysical logging with machine learning for fracture prediction. Nevertheless, challenges exist regarding the model's accuracy. In this study, we present a novel approach to predict fracture density. Our method optimises a back‐propagation (BP) neural network and utilises principal component analysis for feature extraction. We employ logging parameters (density, compensated neutron and acoustic time difference) obtained from Shouyang Block well SY‐1 and fracture density data from electrical imaging logging to construct the FVDC model's dataset. The BP neural network model is optimised using the Sparrow Search algorithm and Tent Chaotic Mapping. The results demonstrate a substantial enhancement over the BP neural network model, with reductions of 80.102% in mean absolute error, 94.182% in mean square error, 75.879% in root mean square error and 79.764% in mean absolute percentage error. When considering accuracy, the optimised model (97.098%) surpasses the support vector regression model (96.478%), the random forest model (94.404%) and the BP neural network model (85.657%). Scalability testing for the optimised model was conducted using data from well SY‐2, yielding a remarkable prediction accuracy of 96.775%. This performance exceeds that of the BP neural network (with an accuracy of 85.102%), as well as the random forest and support vector regression models (with accuracies of 91.234% and 90.384%, respectively). These results underscore the potential of well logging and machine learning in FVDC prediction.
Three‐dimensional view of microglia—amyloid plaque interactions
Authors: Gotkiewicz Maria , Capra Janne , Miettinen Pasi O. , Natunen Teemu , Tanila Heikki 
Published: October 2024

AbstractRecent gene expression studies have revealed about 10 different states of microglia, some of which are characteristic for Alzheimer‐like amyloid plaque pathology. However, it is not presently known how these translate into morphological features that would reflect microglia interaction with amyloid plaques. With optimized conditions for confocal microscopy in amyloid plaque forming APP/PS1 transgenic mice we reveal new details of how microglia processes interact with amyloid plaques. The microglia contacts differed drastically between purely diffuse plaque and those with a fibrillar core. We identified microglia that extend their enlarged processes through the diffuse shell of the amyloid plaques and cover the fibrillar plaque core with snowplow‐like expanded end‐feet. These end‐feet were filled with the lysosomal marker CD68, while both non‐fibrillar and fibrillar amyloid was found in perinuclear vesicles of some “snowplower” microglia. In the organized dense‐core plaques, we consistently saw a layer of Apolipoprotein E (ApoE) between the fibrillar core and the microglial end‐feet. ApoE covered also loose fibrillar amyloid and diffuse amyloid plaques that were about 10 μm or larger in diameter. These findings are compatible with both amyloid plaque phagocytosis and compaction by microglia. Further, they support a chemotactic role of ApoE for microglia contacts with amyloid plaques.
Climate Change and Entrepreneurship: A Review and Research Agenda
Authors: Karadayı Talha , Yazıcı Selim , Akdemir Ömür Gökçe 
Published: October 2024

ABSTRACTAs climate change risks intensify, the role of entrepreneurial activities in addressing these challenges and promoting sustainable development becomes increasingly vital. Through a systematic literature review using a bibliometric analysis of 387 studies from Scopus up to December 31, 2023, this study focuses on the intersection of entrepreneurship and climate change. It contributes to academic understanding by offering insights into current trends for entrepreneurs, researchers, and policymakers. Our analysis examines publication trends, leading authors, countries/regions, and common themes to elucidate research efforts on entrepreneurial activities in the context of climate change. Contrary to typical trends in the geographical distribution, the study identifies a significant increase in contributions from developing countries such as China, India, and the Russian Federation. Furthermore, when evaluating entrepreneurship in the context of climate change, we observe a prominence of innovation and sustainability‐focused approaches. The primary finding of the study is the literature's attribution of significant responsibility to entrepreneurship in combating climate change and its consideration of entrepreneurship as a prerequisite for sustainable approaches. By demonstrating a sustainable attitude, entrepreneurs can contribute to the fight against climate change across various domains, ranging from policy to social life, and from collective efforts in the economy to individual endeavors.
Rapid Whole‐Organ Characterization via Quantitative Light‐Sheet Microscopy
Authors: Chen Lingmei , Su Yijun , Qian Shuhao , Zhou Lingxi , Han Tao , Wang Chuncheng , Jiang Rushan , Ding Zhihua , Guo Min , Liu Zhiyi 
Published: October 2024

AbstractWhole‐organ imaging and characterization at a submicron level provide abundant information on development and diseases while remaining a big challenge, especially in the context of time load. Herein, a quantitative light‐sheet microscopy platform that enabled highly time‐efficient assessments of fibrous structures within the intact cleared tissue is developed. Dual‐view inverted selective plane illumination microscopy (diSPIM), followed by improved registration and deconvolution, led to submicron isotropic imaging of mouse upper genital tract with one hundred‐fold speed‐ups than previous efforts. Further, optical metrics quantifying 3D local density and structural complexity of targets based on parallel and vectorized convolution in both spatial and frequency domains are developed. Collectively, ≈400–2000 fold increases in time efficiency counting for imaging, postprocessing, and quantitative characterization compared to the traditional method is gained. Using this platform, automatic identification of medulla and cortex within the mouse ovary at over 90% overlap with manual selection by anatomy experts is achieved. Additionally, heterogeneous distributions of immune cells in the mouse ovary and fallopian tube, offering a unique perspective for understanding the immune microenvironment are discovered. This work paves the way for future whole‐organ study, and exhibits potential with promise for offering mechanistic insights into physiological and pathological alterations of biological tissues.
Existence and regularity of strict solutions for a class of fractional evolution equations
Authors: Wu Guang Meng , He Jia Wei 
Published: October 2024

AbstractWe study the existence and Hölder regularity of solutions for fractional evolution equations of order . By means of an analytic resolvent, we construct an interpolation space, which can effectively lower the regularity of initial data. By virtue of the interpolation space and some properties of the analytic resolvent, we derive the existence and Hölder regularity of strict solutions for an inhomogeneous problem, as well as the existence and Hölder regularity of a nonlinear problem.