bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence and Incidence of Dementia Due to Alzheimer’s Disease: a Systematic Review and Meta-Analysis
Authors: Fiest Kirsten M. , Roberts Jodie I. , Maxwell Colleen J. , Hogan David B. , Smith Eric E. , Frolkis Alexandra , Cohen Adrienne , Kirk Andrew , Pearson Dawn , Pringsheim Tamara , Venegas-Torres Andres , Jetté Nathalie 
Published: June 2016

AbstractBackgroundUpdated information on the epidemiology of dementia due to Alzheimer’s disease (AD) is needed to ensure that adequate resources are available to meet current and future healthcare needs. We conducted a systematic review and meta-analysis of the incidence and prevalence of AD.MethodsThe MEDLINE and EMBASE databases were searched from 1985 to 2012, as well as the reference lists of selected articles. Included articles had to provide an original population-based estimate for the incidence and/or prevalence of AD. Two individuals independently performed abstract and full-text reviews, data extraction and quality assessments. Random-effects models were employed to generate pooled estimates stratified by age, sex, diagnostic criteria, location (i.e., continent) and time (i.e., when the study was done).ResultsOf 16,066 abstracts screened, 707 articles were selected for full-text review. A total of 119 studies met the inclusion criteria. In community settings, the overall point prevalence of dementia due to AD among individuals 60+ was 40.2 per 1000 persons (CI95%: 29.1-55.6), and pooled annual period prevalence was 30.4 per 1000 persons (CI95%: 15.6-59.1). In community settings, the overall pooled annual incidence proportion of dementia due to AD among individuals 60+ was 34.1 per 1000 persons (CI95%: 16.4-70.9), and the incidence rate was 15.8 per 1000 person-years (CI95%: 12.9-19.4). Estimates varied significantly with age, diagnostic criteria used and location (i.e., continent).ConclusionsThe burden of AD dementia is substantial. Significant gaps in our understanding of its epidemiology were identified, even in a high-income country such as Canada. Future studies should assess the impact of using such newer clinical diagnostic criteria for AD dementia such as those of the National Institute on Aging–Alzheimer’s Association and/or incorporate validated biomarkers to confirm the presence of Alzheimer pathology to produce more precise estimates of the global burden of AD.
“GRACEFUL PILLARS”: LAW, RELIGION, AND THE ETHICS OF THE “DAUGHTER TRACK”
Authors: Green M. Christian 
Published: June 2016

AbstractIn this essay, analyzing the “daughter track” of daughter-provided elder care, through feminist philosopher Lisa Tessman's “burdened virtues” framework, I examine the ethical questions surrounding gender, sacrifice, and elder care on the daughter track, particularly concerning contexts of virtue and necessity. Second, I examine how Tessman's “burdened virtues” framework applies to the “daughter track” situation, particularly regarding virtues born of necessity. Third, I examine some wider legal and social justice issues that remain unresolved in eldercare provision by daughters. Finally, I conclude with some reflections on the “daughter track” as a law and religion issue and how law, in particular, might better support women in being not only “dutiful daughters,” but “graceful pillars,” in the care of their elders.
COSMOPOLITANISM AND COMPETITION: PROBING THE LIMITS OF EGALITARIAN JUSTICE
Authors: Wiens David 
Published: June 2016

Abstract:This paper develops a novelcompetition criterionfor evaluating institutional schemes. Roughly, this criterion says that one institutional scheme is normatively superior to another to the extent that the former engenders more widespread political competition than the latter. I show that this criterion should be endorsed by both global egalitarians and their statist rivals, as it follows from their common commitment to the moral equality of all persons. I illustrate the normative import of the competition criterion by exploring its potential implications for the scope of egalitarian principles of distributive justice. In particular, I highlight the challenges it raises for global egalitarians’ efforts to justify extending the scope of egalitarian justice beyond the state.
Depression risk in patients with heart failure in primary care practices in Germany
Authors: Konrad Marcel , Bohlken Jens , Rapp Michael A , Kostev Karel 
Published: June 2016

ABSTRACTBackground:The goal of this study was to estimate the prevalence of and risk factors for diagnosed depression in heart failure (HF) patients in German primary care practices.Methods:This study was a retrospective database analysis in Germany utilizing the Disease Analyzer® Database (IMS Health, Germany). The study population included 132,994 patients between 40 and 90 years of age from 1,072 primary care practices. The observation period was between 2004 and 2013. Follow-up lasted up to five years and ended in April 2015. A total of 66,497 HF patients were selected after applying exclusion criteria. The same number of 66,497 controls were chosen and were matched (1:1) to HF patients on the basis of age, sex, health insurance, depression diagnosis in the past, and follow-up duration after index date.Results:HF was a strong risk factor for diagnosed depression (p < 0.0001). A total of 10.5% of HF patients and 6.3% of matched controls developed depression after one year of follow-up (p < 0.001). Depression was documented in 28.9% of the HF group and 18.2% of the control group after the five-year follow-up (p < 0.001). Cancer, dementia, osteoporosis, stroke, and osteoarthritis were associated with a higher risk of developing depression. Male gender and private health insurance were associated with lower risk of depression.Conclusions:The risk of diagnosed depression is significantly increased in patients with HF compared to patients without HF in primary care practices in Germany.
Person-centred medicines optimisation policy in England: an agenda for research on polypharmacy
Authors: Heaton Janet , Britten Nicky , Krska Janet , Reeve Joanne 
Published: June 2016

AimTo examine how patient perspectives and person-centred care values have been represented in documents on medicines optimisation policy in England.BackgroundThere has been growing support in England for a policy of medicines optimisation as a response to the rise of problematic polypharmacy. Conceptually, medicines optimisation differs from the medicines management model of prescribing in being based around the patient rather than processes and systems. This critical examination of current official and independent policy documents questions how central the patient is in them and whether relevant evidence has been utilised in their development.MethodsA documentary analysis of reports on medicines optimisation published by the Royal Pharmaceutical Society (RPS), The King’s Fund and National Institute for Health and Social Care Excellence since 2013. The analysis draws on a non-systematic review of research on patient experiences of using medicines.FindingsThe reports varied in their inclusion of patient perspectives and person-centred care values, and in the extent to which they drew on evidence from research on patients’ experiences of polypharmacy and medicines use. In the RPS report, medicines optimisation is represented as being a ‘step change’ from medicines management, in contrast to the other documents which suggest that it is facilitated by the systems and processes that comprise the latter model. Only The King’s Fund report considered evidence from qualitative studies of people’s use of medicines. However, these studies are not without their limitations.We suggest five ways in which researchers could improve this evidence base and so inform the development of future policy: by facilitating reviews of existing research; conducting studies of patient experiences of polypharmacy and multimorbidity; evaluating medicines optimisation interventions; making better use of relevant theories, concepts and tools; and improving patient and public involvement in research and in guideline development.
Geology reviewed for the Falkland Islands and their offshore sedimentary basins, South Atlantic Ocean
Authors: Stone Philip 
Published: June 2016

ABSTRACTThe position of the Falkland Islands adjacent to the South American continental margin belies the close association of their geology with that of South Africa. A Mesoproterozoic basement is unconformably overlain by a Silurian to Devonian succession of fluvial to neritic and shallow marine, siliciclastic strata. This is disconformably succeeded by a largely Permian succession that, near its base, includes a glacigenic diamictite and, thence, passes upwards into a succession of deltaic and lacustrine strata. The lithological succession and the character of its deformation bear striking similarities to the Cape Fold Belt and Karoo retroarc foreland basin. Swarms of Early Jurassic dykes were coeval with the Karoo magmatism and the initial break-up of Gondwana; Early Cretaceous dykes were intruded during the opening of the South Atlantic Ocean. Offshore sedimentary basins surrounding the archipelago contain Late Jurassic to Palaeogene successions and are currently the focus of hydrocarbon exploration. Best known is the North Falkland Basin, a classic failed rift. To the SE, the passive margin, Falkland Plateau Basin may also be rift-controlled, whilst the South Falkland Basin is a foreland basin created at the boundary of the South American and Scotia plates. The role of the Falkland Islands during the breakup of Gondwana remains controversial. Compelling evidence from the onshore geology favours rotation of an independent microplate from an original position adjacent to the Eastern Cape, South Africa. Alternative interpretations, justified largely from offshore geology, favour extension of the Falkland Plateau as a fixed promontory from the South American margin.
Structure and inference in annotated networks
Authors: Newman M. E. J. , Clauset Aaron 
Published: June 2016

AbstractFor many networks of scientific interest we know both the connections of the network and information about the network nodes, such as the age or gender of individuals in a social network. Here we demonstrate how this ‘metadata’ can be used to improve our understanding of network structure. We focus in particular on the problem of community detection in networks and develop a mathematically principled approach that combines a network and its metadata to detect communities more accurately than can be done with either alone. Crucially, the method does not assume that the metadata are correlated with the communities we are trying to find. Instead, the method learns whether a correlation exists and correctly uses or ignores the metadata depending on whether they contain useful information. We demonstrate our method on synthetic networks with known structure and on real-world networks, large and small, drawn from social, biological and technological domains.
Pliocene-Quaternary crustal melting in central and northern Tibet and insights into crustal flow
Authors: Wang Qiang , Hawkesworth Chris J. , Wyman Derek , Chung Sun-Lin , Wu Fu-Yuan , Li Xian-Hua , Li Zheng-Xiang , Gou Guo-Ning , Zhang Xiu-Zheng , Tang Gong-Jian , Dan Wei , Ma Lin , Dong Yan-Hui 
Published: June 2016

AbstractThere is considerable controversy over the nature of geophysically recognized low-velocity–high-conductivity zones (LV–HCZs) within the Tibetan crust, and their role in models for the development of the Tibetan Plateau. Here we report petrological and geochemical data on magmas erupted 4.7–0.3 Myr ago in central and northern Tibet, demonstrating that they were generated by partial melting of crustal rocks at temperatures of 700–1,050 °C and pressures of 0.5–1.5 GPa. Thus Pliocene-Quaternary melting of crustal rocks occurred at depths of 15–50 km in areas where the LV–HCZs have been recognized. This provides new petrological evidence that the LV–HCZs are sources of partial melt. It is inferred that crustal melting played a key role in triggering crustal weakening and outward crustal flow in the expansion of the Tibetan Plateau.
Genetics affects choice of academic subjects as well as achievement
Authors: Rimfeld Kaili , Ayorech Ziada , Dale Philip S. , Kovas Yulia , Plomin Robert 
Published: June 2016

AbstractWe have previously shown that individual differences in educational achievement are highly heritable throughout compulsory education. After completing compulsory education at age 16, students in England can choose to continue to study for two years (A-levels) in preparation for applying to university and they can freely choose which subjects to study. Here, for the first time, we show that choosing to do A-levels and the choice of subjects show substantial genetic influence, as does performance after two years studying the chosen subjects. Using a UK-representative sample of 6584 twin pairs, heritability estimates were 44% for choosing to do A-levels and 52–80% for choice of subject. Achievement after two years was also highly heritable (35–76%). The findings that DNA differences substantially affect differences in appetites as well as aptitudes suggest a genetic way of thinking about education in which individuals actively create their own educational experiences in part based on their genetic propensities.
Continous application of bioorganic fertilizer induced resilient culturable bacteria community associated with banana Fusarium wilt suppression
Authors: Fu Lin , Ruan Yunze , Tao Chengyuan , Li Rong , Shen Qirong 
Published: June 2016

AbstractFusarium wilt of banana always drives farmers to find new land for banana cultivation due to the comeback of the disease after a few cropping years. A novel idea for solving this problem is the continuous application of bioorganic fertilizer (BIO), which should be practiced from the beginning of banana planting. In this study, BIO was applied in newly reclaimed fields to pre-control banana Fusarium wilt and the culturable rhizobacteria community were evaluated using Biolog Ecoplates and culture-dependent denaturing gradient gel electrophoresis (CD-DGGE). The results showed that BIO application significantly reduced disease incidences and increased crop yields, respectivly. And the stabilized general bacterial metabolic potential, especially for the utilization of carbohydrates, carboxylic acids and phenolic compounds, was induced by BIO application. DGGE profiles demonstrated that resilient community structure of culturable rhizobacteria with higher richness and diversity were observed in BIO treated soils. Morever, enriched culturable bacteria affiliated with Firmicutes, Gammaproteobacteria and Actinobacteria were also detected. In total, continuous application of BIO effectively suppressed Fusarium wilt disease by stabilizing culturable bacterial metabolic potential and community structure. This study revealed a new method to control Fusarium wilt of banana for long term banana cultivation.
Contribution of mono and polysaccharides to heterotrophic N2 fixation at the eastern Mediterranean coastline
Authors: Rahav E. , Giannetto M. J. , Bar-Zeev E. 
Published: June 2016

AbstractN2 fixation should be a critical process in the nitrogen-poor surface water of the eastern Mediterranean Sea. Despite favorable conditions, diazotroph abundance and N2 fixation rates remains low for reasons yet explained. The main goal of this study was to investigate the limiting nutrients for diazotrophy in this oligotrophic environment. Hence, we conducted dedicated bottle-microcosms with eastern Mediterranean Sea water that were supplemented with mono and polysaccharides as well as inorganic nitrogen and phosphorous. Our results indicate that the diazotrophic community expressing nifH was primarily represented by heterotrophic Proteobacteria. N2 fixation and heterotrophic bacterial activity increased up-to tenfold following two days of dark incubations, once seawater was supplemented with organic carbon substrate in the form of glucose (monosaccharides) or gum-xanthan (polysaccharide surrogate). Furthermore, our results point that carbon-rich polysaccharides, such as transparent exopolymer particles, enhance heterotrophic N2 fixation, by forming microenvironments of intense metabolic activity, high carbon: nitrogen ratio, and possibly low O2 levels. The conclusions of this study indicate that diazotrophs in the eastern Mediterranean coast are primarily limited by organic carbon substrates, as possibly in many other marine regions.
NG2 expression in microglial cells affects the expression of neurotrophic and proinflammatory factors by regulating FAK phosphorylation
Authors: Zhu Lie , Su Qing , Jie Xiang , Liu Antang , Wang Hui , He Beiping , Jiang Hua 
Published: June 2016

AbstractNeural/glial antigen 2 (NG2), a chondroitin sulfate proteoglycan, is significantly upregulated in a subset of glial cells in the facial motor nucleus (FMN) following CNS injury. NG2 is reported to promote the resulting inflammatory reaction, however, the mechanism by which NG2 mediates these effects is yet to be determined. In this study, we examined the changes in NG2 expressing microglial cells in the FMN in response to facial nerve axotomy (FNA) in mice. Our findings indicated that NG2 expression was progressively induced and upregulated specifically in the ipsilateral facial nucleus following FNA. To further investigate the effects of NG2 expression, in vivo studies in NG2-knockout mice and in vitro studies in rat microglial cells transfected with NG2 shRNAs were performed. Abolition of NG2 expression both in vitro and in vivo resulted in increased expression of neurotrophic factors (nerve growth factor and glial derived neurotrophic factor), decreased expression of inflammatory mediators (tumor necrosis factor-α and interleukin-1β) and decreased apoptosis in the ipsilateral facial nucleus in response to FNA. Furthermore, we demonstrated the role of FAK in these NG2-induced effects. Taken together, our findings suggest that NG2 expression mediates inflammatory reactions and neurodegeneration in microglial cells in response to CNS injury, potentially by regulating FAK phosphorylation.
Multi-class texture analysis in colorectal cancer histology
Authors: Kather Jakob Nikolas , Weis Cleo-Aron , Bianconi Francesco , Melchers Susanne M. , Schad Lothar R. , Gaiser Timo , Marx Alexander , Zöllner Frank Gerrit 
Published: June 2016

AbstractAutomatic recognition of different tissue types in histological images is an essential part in the digital pathology toolbox. Texture analysis is commonly used to address this problem; mainly in the context of estimating the tumour/stroma ratio on histological samples. However, although histological images typically contain more than two tissue types, only few studies have addressed the multi-class problem. For colorectal cancer, one of the most prevalent tumour types, there are in fact no published results on multiclass texture separation. In this paper we present a new dataset of 5,000 histological images of human colorectal cancer including eight different types of tissue. We used this set to assess the classification performance of a wide range of texture descriptors and classifiers. As a result, we found an optimal classification strategy that markedly outperformed traditional methods, improving the state of the art for tumour-stroma separation from 96.9% to 98.6% accuracy and setting a new standard for multiclass tissue separation (87.4% accuracy for eight classes). We make our dataset of histological images publicly available under a Creative Commons license and encourage other researchers to use it as a benchmark for their studies.
An Acinetobacter trimeric autotransporter adhesin reaped from cells exhibits its nonspecific stickiness via a highly stable 3D structure
Authors: Yoshimoto Shogo , Nakatani Hajime , Iwasaki Keita , Hori Katsutoshi 
Published: June 2016

AbstractTrimeric autotransporter adhesins (TAAs), cell surface proteins of Gram-negative bacteria, mediate bacterial adhesion to host cells and extracellular matrix proteins. However, AtaA, a TAA in the nonpathogenic Acinetobacter sp. strain Tol 5, shows nonspecific, high adhesiveness to abiotic material surfaces as well as to biotic surfaces. AtaA is a homotrimer of polypeptides comprising 3,630 amino acids and forms long nanofibers; therefore, it is too large and structurally complex to be produced as a recombinant protein. In this study, we isolated AtaA’s passenger domain (AtaA PSD), which is translocated to the cell surface through the C-terminal transmembrane domain and exhibits biological functions, using a new method. We introduced a protease recognition site and reaped AtaA nanofibers 225 nm in length from the cell surface through proteolytic cleavage with a specific protease. Biochemical and biophysical analyses of the purified native AtaA PSD revealed that it has a stable structure under alkaline and acidic conditions. Temperatures above 80 °C, which disrupted AtaA’s higher-order structure but maintained the full-length AtaA polypeptide, inactivated AtaA’s nonspecific adhesiveness, suggesting that the stickiness of AtaA requires its 3D structure. This finding refutes the widespread but vague speculation that large unfolded polypeptides readily stick to various surfaces.
Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder
Authors: Tian Yanghua , Du Jing , Spagna Alfredo , Mackie Melissa-Ann , Gu Xiaosi , Dong Yi , Fan Jin , Wang Kai 
Published: June 2016

AbstractAttention plays an essential role in supporting other cognitive functions and behavior and disturbance of attention is one of the most common symptoms in major depressive disorder (MDD). Although treatment with venlafaxine for MDD symptoms has been shown to reduce deficits in cognition and emotion regulation, it remains unclear whether venlafaxine improves specific attentional functions. We used the Attention Network Test to measure the attentional functions of alerting, orienting and executive control before and after treatment with venlafaxine in patients with MDD compared to untreated healthy controls. Before treatment, the MDD group showed a selective impairment in alerting and executive control of attention, while there were no significant group differences in the orienting function. The interaction between group and session was significant for executive control and after treatment with venlafaxine, the performance of the MDD group on executive control of attention was not significantly different from that of controls. Reported symptoms of MDD were also significantly reduced after treatment with venlafaxine. These results demonstrate that treatment with venlafaxine selectively normalizes the executive control function of attention in addition to improving clinical symptoms in MDD.
Morphology evolution and pure red upconversion mechanism of β-NaLuF4 crystals
Authors: Lin Hao , Xu Dekang , Li Anming , Teng Dongdong , Yang Shenghong , Zhang Yueli 
Published: June 2016

AbstractA series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb3+, Tm3+, Er3+ and Li+ doped β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+. Based on the rate equations, we report the theoretical model about the pure red UC mechanism in Yb3+/Tm3+/Er3+ doped system. It is proposed that the pure red UC luminescence is mainly ascribed to the energy transfer UC from Tm3+:3F4 → 3H6 to Er3+:4I11/2 → 4F9/2 and the cross-relaxation (CR) effect [Er3+:4S3/2 + 4I15/2 → 4I9/2 + 4I13/2] rather than the long-accepted mechanism [CR process among Er3+:4F7/2 + 4I11/2 → 4F9/2 + 4F9/2]. In addition, compared to the Li+-free counterpart, the pure red UC luminescence in β-NaLuF4:20% Yb3+, 1% Tm3+, 20% Er3+ with 15 mol% Li+ doping is enhanced by 13.7 times. This study provides a general and effective approach to obtain intense pure red UC luminescence, which can be applied to other synthetic strategies.