bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROPOSTAS PARA CAPACITAÇÃO DE AGENTES INSTITUCIONAIS E COMUNITÁRIOS PARA O ATENDIMENTO DA CRIANÇA DE 0 A 6 ANOS NO BRASIL
Authors: Siqueira Arnaldo Augusto Franco de , Correa Maria Elena G. 
Published: March 2017

São apresentados aqui os relatórios dos grupos de trabalho sobre temas pertinentes à capacitação de recursos humanos para o atendimento da criança d~ 0 a 6 anos em nosso meio. Foram abordados os temas: formação participativa de recursos humanos em educação, comunicação e informação; as modalidades de atendimento em educação e saúde com crianças de 0 a 6 anos; o desenvolvimento e a aprendizagem; capacitação de multiplicadores e a legislação. Buscou-se,ésempre, além da contextuação do tema, definir os referenciais teóricos e metodológicos, bem como chegar a propostas de capacitação que garantissem a perspectiva teórico-metodológica da participação.
IDENTIDADE E SEXUALIDADE NO DISCURSO ADOLESCENTE
Authors: Domingues Carla Magda Allan Santos , Alvarenga Augusta Thereza de 
Published: March 2017

Tendo em vista interpretar a concepção de adolescência a partir do discurso dos próprios sujeitos sociais, o presente trabalho objetivou caracterizar o processo de construção da identidade do adolescente, a partir de múltiplas identificações que o conformam. Considerando que na adolescência relações de género emergentes e manifestações da sexualidade assumem significações particulares no processo de formação dessa identidade procurou-se, igualmente, reter tais aspectos com a finalidade de apreender as características assumidas no processo considerando o espaço social tia qual se movimentam. Nesse sentido, a identificação de padrões culturais, valores sociais e ideológicos, que formam e conformam tal processo, passam a representar o universo no qual se inscreve o grupo estudado, caracterizado por 31 adolescentes estudantes, entre 15 a 19 anos, de ambos os sexos, categorizados em três segmentos sociais, pertencentes a dada área do Município de São Paulo.
A CRECHE COMO CONTEXTO SOCIO-AFETIVO DE DESENVOLVIMENTO: OS PADROES INTERACIONAIS E O AJUSTAMENTO DAS CRIANÇAS
Authors: Bussab Vera Silvia Raad , Maluf Maria Paula Costacurta 
Published: March 2017

O estudo do comportamento de crianças em creches tornou-se de fundamental importancia na vida contemporânea, em virtude da substancial adesão a esse modo de criação eda compreensão da importância do contexto sócio-afetivo cotidiano para o desenvolvimento do individuo. A presente pesquisa visou estudar os tipos de interações sociais de crianças de 4 anos, em uma creche pública estadual, com o objetivo de estabelecer relações entre os vários comportamentos das crianças e identificar possíveis padrões de ajustamento social e afetivo à creche. Foram feitas gravações em video, pelo método sujeito focal, de 22 crianças em recreação livre, em 6 sessões de 10 minutos para cada sujeito, distribuídas ao longo de 2 meses. Os dados da totalização das frequências de cada categoria observada foram analisados estatisticamente através de testes de correlação de Pearson e de testes t de comparação de médias. Estas análisesrevelaram a existência de padrões interacionais definidos, especialmente em função do nivel de ir^lteruçõés positivas. Crianças que se envolveram em poucas interações positivas tenderam a apresentar uma distribuição tipica dos demais comportamentos, oposta à verificada no caso das crianças que interagiram muito. Níveis baixos de interações positivas apareceram correlacionados com: 1- níveis altos de observar os demais, o que enfraquece uma suposição de desinteressesocial como explicação para a falta de intonações positivas; 2- níveis altos de apatia, sugestivos de dificuldade no ajustamento à situação; 3- níveis baixos de alguns padrões agressivos. No presente estudo, estes efeitos não foram modulados por tempo de creche, talvez pela ausência detempos menores do que 2 anos, e nem por sexo, possivelmente pela complexidade de interação desta variável com as demais.
SAÚDE E SAGRADO: REPRESENTAÇÕES DA DOENÇA E PRÁTICAS DE ATENDIMENTO DOS SACERDOTES SUPREMOS DO CANDOMBLÉ JÊJE-NAGÔ DO BRASIL
Authors: Santos Alessandro De Oliveira dos 
Published: March 2017

O objetivo deste artigo é caracterizar a figura dos sacerdotes supremos do Candomblé Jejê-Nagô do Brasil, bem como as principais práticas de atendimento utilizadas por eles para promover a saúde, prevenir e lidar com a doença. No Brasil estes sacerdotes vêm se responsabilizando pelo atendimento a uma grande demanda por busca de alívio e ou tratamento no âmbito da doença, oferecendo, através de uma orientação transcendente, elementos para organizar a experiência caótica do sofredor e daqueles diretamente envolvidos no caso.
NECESSIDADES (DE SAÚDE) DE ADOLESCENTES DO D.A. RAPOSO TAVARES, SP, REFERIDAS À FAMILIA, ESCOLA E BAIRRO
Authors: Soares Cássia B. , Avila Livia K. de , Salvetti Marina De G. 
Published: March 2017

Este estudo, de natureza epidemiológica descritiva, objetiva caracterizar as necessidades de saúde dos adolescentes do Distrito Administrativo Raposo Tavares - município de São Paulo, que apresenta diversas situações de vulnerabilidade social. Foram estudados 133 adolescentes e suas famílias, inscritos em 1 2 escolas públicas e I Centro de Juventude, buscando localizar as suas necessidades de saúde a partir das suas formas de inserção social (plenamente incluidos, precariamente incluidos e excluidos). Os resultados indicam que às formas de reprodução evidenciadas na amostra estudada se associavam necessidades diferenciados, seja do ponto de vista quantitativo, seja do ponto de vista qualitativo, relacionadas às agências e ao espaço de socialização: família, escola e bairro. São necessárias ações intersetoriais, não só de incremento das políticas sociais públicas, mas de capacitação dos adolescentes para que exerçam seus direitos sociais e possam dispor de processos de socialização acolhedores e protetores.
CRIANÇAS DO SERTÃO: MODOS DE VIDA. UM ESTUDO ETNOGRÁFICO DAS FAMÍLIAS DE SANTA CRUZ DO BANABUIÚ, CEARÁ
Authors: Silva Francileide Santana da , Azevedo Maria Raquel de Carvalho 
Published: March 2017

Este estudo etnográfico é parte integrante da primeira etapa do projeto Lugar de Criança~. Objetivou-se conhecer o modo de vida- organização familiar, as práticas culturais de cuidado das crianças na faixa etária de zero a sete anos e suas farnilias, ambos residentes no semiárido. Inicialmente foram visitadas 81 familias pertencentes a zona urbana e rural do distrito de Santa C^luz do Banabuiú, municipio de Pedra Branca. Em um segundo momento, 24 destas famílias foram revisitadas, entrevistadas e observadas, utilizando a metodologia de observação participante e diário de campo centrados no ambito familiar. As entrevistas foram realizadas com as mães, e as observações da familia seguiram um roteiro semi-estruturado. Percebeu-se a relação entre as práticas familiares e o ambiente de seca revelados no cuidado com a alimentação e higiene, a arquitetura das casas e nas falas da religiosidade popular. Frente à escassez de água, à baixa produção agrícola, aos empregos altamente rotativos e às questões de saúde, as familias criam suas próprias estratégias de convivência com o ambiente, cabendo à criança ajudar a familia.
Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross‐sectional study in Papua New Guinea
Authors: Vallely Andrew J , MacLaren David , David Matthew , Toliman Pamela , Kelly‐Hanku Angela , Toto Ben , Tommbe Rachael , Kombati Zure , Kaima Petronia , Browne Kelwyn , Manineng Clement , Simeon Lalen , Ryan Claire , Wand Handan , Hill Peter , Law Greg , Siba Peter M , McBride W John H , Kaldor John M 
Published: March 2017

AbstractIntroduction: Various forms of penile foreskin cutting are practised in Papua New Guinea. In the context of an ecological association observed between HIV infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level.Methods: We conducted a cross‐sectional study among men attending voluntary confidential HIV counselling and testing clinics. Following informed consent, participants had a face‐to‐face interview and an examination to categorize foreskin status. HIV testing was conducted on site and relevant specimens collected for laboratory‐based Herpes simplex type‐2 (HSV‐2), syphilis, Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) testing.Results: Overall, 1073 men were enrolled: 646 (60.2%) were uncut; 339 (31.6%) had a full dorsal longitudinal cut; 72 (6.7%) a partial dorsal longitudinal cut; and 14 (1.3%) were circumcised. Overall, the prevalence of HIV was 12.3%; HSV‐2, 33.6%; active syphilis, 12.1%; CT, 13.4%; NG, 14.1%; and TV 7.6%. Compared with uncut men, men with a full dorsal longitudinal cut were significantly less likely to have HIV (adjusted odds ratio [adjOR] 0.25, 95%CI: 0.12, 0.51); HSV‐2 (adjOR 0.60, 95%CI: 0.41, 0.87); or active syphilis (adjOR 0.55, 95%CI: 0.31, 0.96). This apparent protective effect was restricted to men cut prior to sexual debut. There was no difference between cut and uncut men for CT, NG or TV.Conclusions: In this large cross‐sectional study, men with a dorsal longitudinal foreskin cut were significantly less likely to have HIV, HSV‐2 and syphilis compared with uncut men, despite still having a complete (albeit morphologically altered) foreskin. The protective effect of the dorsal cut suggests that the mechanism by which male circumcision works is not simply due to the removal of the inner foreskin and its more easily accessible HIV target cells. Exposure of the penile glans and inner foreskin appear to be key mechanisms by which male circumcision confers protection.Further research in this unique setting will help improve our understanding of the fundamental immunohistologic mechanisms by which male circumcision provides protection, and may lead to new biomedical prevention strategies at the mucosal level.
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium
Authors: Hernandez-Cascales Jesús 
Published: March 2017

BackgroundResveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity. Thus, it is possible that resveratrol increases the inotropic effect of sympathomimetic agents, as PDE inhibitors do but, unlike other PDE inhibitors, its effect may not be accompanied by proarrhythmia due to its antiarrhythmic action. This work is aimed to test this hypothesis.MethodsThis is an “in vitro” concentration-response relationship study. The effects of noradrenaline, tyramine and isoproterenol, alone or in combination with either resveratrol or with the typical PDE inhibitor 3-isobutylmethylxantine (IBMX), were studied in electrically driven strips of right ventricle or in the spontaneously beating free wall of the right ventricle of rat heart in order to investigate inotropic or proarrhythmic effects respectively. Also, the effects of resveratrol or IBMX on the sinoatrial node rate were examined in the isolated right atria of rat heart.ResultsResveratrol (10 µM and 100 µM) produces a leftward shift in the concentration-response curves for the contractile effects of noradrenaline, tyramine or isoproterenol and reduces the –log EC50values of these three agents. IBMX produces similar effects. The spontaneous ventricular beating rate was increased by all three compounds, an effect that was further enhanced by the addition of IBMX. In contrast, resveratrol (100 µM) abolished the effects of these sympathomimetic agents on the ventricular rate. Resveratrol (1–100 µM) had no effect on the sinoatrial node rate, while IBMX produce a concentration dependent sinoatrial tachycardia.DiscussionTaken together, the finding, indicate that resveratrol, like the PDE inhibitor IBMX enhances the contractile effects of sympathomimetic agents but, in contrast to IBMX, it does not enhance their proarrhythmic effect or produce sinoatrial tachycardia. This is most probably consequence of the antiarrhythmic effect of resveratrol which protect against the proarrhythmic effects resulting from PDE inhibition.
A direct examination of the dynamics of dipolarization fronts using MMS
Authors: Yao Z. H. , Rae I. J. , Guo R. L. , Fazakerley A. N. , Owen C. J. , Nakamura R. , Baumjohann W. , Watt C. E. J. , Hwang K. J. , Giles B. L. , Russell C.T. , Torbert R. B. , Varsani A. , Fu H. S. , Shi Q. Q. , Zhang X.‐J. 
Published: March 2017

AbstractEnergy conversion on the dipolarization fronts (DFs) has attracted much research attention through the suggestion that intense current densities associated with DFs can modify the more global magnetotail current system. The current structures associated with a DF are at the scale of one to a few ion gyroradii, and their duration is comparable to a spacecraft's spin period. Hence, it is crucial to understand the physical mechanisms of DFs with measurements at a timescale shorter than a spin period. We present a case study whereby we use measurements from the Magnetospheric Multiscale (MMS) Mission, which provides full 3‐D particle distributions with a cadence much shorter than a spin period. We provide a cross validation amongst the current density calculations and examine the assumptions that have been adopted in previous literature using the advantages of MMS mission (i.e., small‐scale tetrahedron and high temporal resolution). We also provide a cross validation on the terms in the generalized Ohm's law using these advantageous measurements. Our results clearly show that the majority of the currents on the DF are contributed by both ion and electron diamagnetic drifts. Our analysis also implies that the ion frozen‐in condition does not hold on the DF, while electron frozen‐in condition likely holds. The new experimental capabilities allow us to accurately calculate Joule heating within the DF, which shows that plasma energy is being converted to magnetic energy in our event.
Thermal effect of climate change on groundwater‐fed ecosystems
Authors: Burns Erick R. , Zhu Yonghui , Zhan Hongbin , Manga Michael , Williams Colin F. , Ingebritsen Steven E. , Dunham Jason B. 
Published: March 2017

AbstractGroundwater temperature changes will lag surface temperature changes from a changing climate. Steady state solutions of the heat‐transport equations are used to identify key processes that control the long‐term thermal response of springs and other groundwater discharge to climate change, in particular changes in (1) groundwater recharge rate and temperature and (2) land‐surface temperature transmitted through the vadose zone. Transient solutions are developed to estimate the time required for new thermal signals to arrive at ecosystems. The solution is applied to the volcanic Medicine Lake highlands, California, USA, and associated springs complexes that host groundwater‐dependent ecosystems. In this system, upper basin groundwater temperatures are strongly affected only by recharge conditions. However, as the vadose zone thins away from the highlands, changes in the average annual land‐surface temperature also influence groundwater temperatures. Transient response to temperature change depends on both the conductive time scale and the rate at which recharge delivers heat. Most of the thermal response of groundwater at high elevations will occur within 20 years of a shift in recharge temperatures, but the large lower elevation springs will respond more slowly, with about half of the conductive response occurring within the first 20 years and about half of the advective response to higher recharge temperatures occurring in approximately 60 years.
Stereoselective Synthesis of 7‐(E)‐Arylidene‐2‐chloro‐6‐azabicyclo[3.2.1]octanes via Aluminum Chloride‐Promoted Cyclization/Chlorination of Six‐Membered Ring 3‐Enynamides
Authors: Yeh Ming‐Chang P. , Chang Yi‐Mei , Lin Hsin‐Hui 
Published: March 2017

AbstractAn efficient stereoselective synthesis of 7‐(E)‐arylidene‐2‐chloro‐6‐azabicyclo[3.2.1]octanes is described. The aluminum chloride‐promoted cyclization/chlorination of six‐membered ring 3‐enynamides enables a straightforward approach to the 6‐azabicyclo[3.2.1]octane nucleus that is incorporated in many biologically active compounds. Acid treatment of the resultant chlorinated arylideneazabicyclooctanes furnishes 3‐alkanoyl‐4‐chlorocyclohexanamines in excellent yields and high stereoselectivity.magnified image
Cardiac arrest caused by sibutramine obtained over the Internet: a case of a young woman without pre‐existing cardiovascular disease successfully resuscitated using extracorporeal membrane oxygenation
Authors: Bunya Naofumi , Sawamoto Keigo , Uemura Shuji , Kyan Ryoko , Inoue Hiroyuki , Nishida Junichi , Kouzu Hidemichi , Kokubu Nobuaki , Miura Tetsuji , Narimatsu Eichi 
Published: March 2017

CaseSibutramine is a weight loss agent that was withdrawn from the market in the USA and European Union because it increases adverse events in patients with cardiovascular diseases. However, non‐prescription weight loss pills containing sibutramine can be still easily purchased over the Internet.A 21‐year‐old woman without history of cardiovascular diseases developed cardiac arrest. She was a user of a weight loss pills, containing sibutramine and hypokalemia‐inducing agents, imported from Thailand over the Internet.OutcomeShe was successfully resuscitated without any neurological deficits by using extracorporeal membrane oxygenation for refractory ventricular fibrillation.ConclusionThis case indicates that sibutramine can cause cardiac arrest even in subjects without pre‐existing cardiovascular disease when combined with agents that promote QT prolongation.
Die anellierende Erweiterung von π‐Systemen (APEX‐Reaktion): ein rascher Zugang zu kondensierten Arenen, Heteroarenen und Nanographenen
Authors: Ito Hideto , Ozaki Kyohei , Itami Kenichiro 
Published: March 2017

AbstractDie anellierende Erweiterung von π‐Systemen (APEX‐Reaktion) hat das Potential, die Materialwissenschaften, das Bioimaging und die pharmazeutische/agrochemische Industrie enorm zu beeinflussen, da sie einen Zugang zu kondensierten aromatischen Systemen ausgehend von relativ simplen aromatischen Verbindungen in einem einzigen Schritt ermöglicht. Üblicherweise vereinfacht eine APEX‐Reaktion die Erweiterung eines π‐Systems im Eintopfverfahren, ohne präfunktionalisierte aromatische Verbindungen zu benötigen. Diese vorteilhafte Eigenschaft ist zur Einstellung und Modifikation molekularer Eigenschaften im letzten Schritt einer Synthese besonders nützlich. In diesem Aufsatz werden die Fortschritte und Anwendungen von APEX‐Reaktionen unfunktionalisierter Arene und Heteroarene beschrieben.
Cyanobacterial ent‐Sterol‐Like Natural Products from a Deviated Ubiquinone Pathway
Authors: Moosmann Philipp , Ueoka Reiko , Grauso Laura , Mangoni Alfonso , Morinaka Brandon I. , Gugger Muriel , Piel Jörn 
Published: March 2017

AbstractNatural products from marine animals show high potential for the development of new medicines, but drug development based on these compounds is commonly hampered by their low natural abundance. Since many of these metabolites are suspected or known to be produced by uncultivated bacterial symbionts, the rapidly growing diversity of sequenced prokaryotic genomes offers the opportunity to identify alternative, culturable sources of natural products computationally. In this work, we investigated the potential of using this sequenced resource to facilitate the production of meroterpenoid‐like compounds related to those from marine sources. This genome‐mining strategy revealed a biosynthetic gene cluster for highly modified cytotoxic meroterpenoids related to pelorol and other compounds isolated from sponges. Functional characterization of the terpene cyclase MstE showed that it generates an ent‐sterol‐like skeleton fused to an aryl moiety from an open‐chain precursor and is therefore a promising tool for the chemoenzymatic preparation of synthetically challenging chemical scaffolds.
A Challenging Pie to Splice: Drugging the Spliceosome
Authors: León Brian , Kashyap Manoj K. , Chan Warren C. , Krug Kelsey A. , Castro Januario E. , La Clair James J. , Burkart Michael D. 
Published: March 2017

AbstractSince its discovery in 1977, the study of alternative RNA splicing has revealed a plethora of mechanisms that had never before been documented in nature. Understanding these transitions and their outcome at the level of the cell and organism has become one of the great frontiers of modern chemical biology. Until 2007, this field remained in the hands of RNA biologists. However, the recent identification of natural product and synthetic modulators of RNA splicing has opened new access to this field, allowing for the first time a chemical‐based interrogation of RNA splicing processes. Simultaneously, we have begun to understand the vital importance of splicing in disease, which offers a new platform for molecular discovery and therapy. As with many natural systems, gaining clear mechanistic detail at the molecular level is key towards understanding the operation of any biological machine. This minireview presents recent lessons learned in this emerging field of RNA splicing chemistry and chemical biology.
Electrochemical and photocatalytic hydrogen evolution by an electron‐deficient cobalt tris(ethoxycarbonyl)corrole complex
Authors: Yuan Hui‐Qing , Wang Hua‐Hua , Kandhadi Jaipal , Wang Hui , Zhan Shu‐Zhong , Liu Hai‐Yang 
Published: March 2017

An electron‐deficient flat 5,10,15‐tris(ethoxycarbonyl)corrole (TECC) cobalt complex, [Co(TECC)(Py)2] (1; py = pyridine), was prepared and employed as a catalyst for homogeneous hydrogen evolution. It turns out that water can be successfully used as a proton source in acetonitrile–water (2:3 v/v) solvent system for electrocatalytic hydrogen evolution. Complex 1 is also an efficient photocatalyst for hydrogen generation from aqueous solution, an example of the first application of metal corrole as photocatalyst for hydrogen production.
Factors Influencing Consumer Willingness to Pay for Low‐Carbon Products: A Simulation Study in China
Authors: Liu Yong , Yang Dewei , Xu Hengzhou 
Published: March 2017

AbstractConsumer choice behavior is crucial to supporting cleaner production and plays an essential role in low‐carbon development and environmental policy‐making. Therefore, combining system dynamics with an agent‐based model (SD–AB), the present study explores influencing factors on both providers' and consumers' sides. Using empirical data from selected firms and a questionnaire survey of residents in China, the simulation results revealed that consumers' low‐carbon awareness and income have little effect on their willingness to pay for low‐carbon products. In contrast, some factors have an obvious effect on consumers' willingness to pay for low‐carbon products, including the delivery speed of low‐carbon products, consumers' patience and degree of satisfaction. Thus, companies that provide low‐carbon products should be more focused on customer expectations and should ensure timely and efficient delivery to consumers. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment