bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide
Authors: Di Giglio Maria Giulia , Muttenthaler Markus , Harpsøe Kasper , Liutkeviciute Zita , Keov Peter , Eder Thomas , Rattei Thomas , Arrowsmith Sarah , Wray Susan , Marek Ales , Elbert Tomas , Alewood Paul F. , Gloriam David E. , Gruber Christian W. 
Published: February 2017

AbstractCharacterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger), identified and cloned its cognate receptor and determined its pharmacological properties on the insect and human oxytocin/vasopressin receptors. Subsequently, we identified a functional dichotomy: inotocin activated the insect inotocin and the human vasopressin V1b receptors, but inhibited the human V1aR. Replacement of Arg8 of inotocin by D-Arg8 led to a potent, stable and competitive V1aR-antagonist ([D-Arg8]-inotocin) with a 3,000-fold binding selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R. The Arg8/D-Arg8 ligand-pair was further investigated to gain novel insights into the oxytocin/vasopressin peptide-receptor interaction, which led to the identification of key residues of the receptors that are important for ligand functionality and selectivity. These observations could play an important role for development of oxytocin/vasopressin receptor modulators that would enable clear distinction of the physiological and pathological responses of the individual receptor subtypes.
MONETARY AND FISCAL POLICIES INTERACTION IN MONETARY UNIONS
Authors: Foresti Pasquale 
Published: February 2017

AbstractIn this paper, the literature on the interaction between monetary and fiscal policies in a monetary union is surveyed. By adopting the concept of symbiosis as a starting point, the paper highlights the importance of uncertainty, policy makers' preferences and targets. Then, the role of commitment to policy rules and coordination is addressed. The analysis also focuses on the importance of the data considered for the generation of the policy mix. As a final step, the paper discusses the main results in the literature on public debt management in a monetary union. All the reported theoretical results are then adopted to retrieve policy and institutional implications for the European Monetary Union.
Modified cranial closing wedge osteotomy for treatment of cranial cruciate ligament insufficiency in dogs with excessive tibial plateau angles: Technique and complications in 19 cases
Authors: Frederick Steven W. , Cross Alan R. 
Published: February 2017

AbstractObjectiveTo describe short‐term outcomes of a modified cranial closing wedge osteotomy (CCWO) for treatment of dogs with cranial cruciate ligament disease and excessive tibial plateau angle (eTPA).Study DesignRetrospective clinical study.Animals18 client‐owned dogs (19 stifles) with cranial cruciate ligament disease and eTPA (>34°).MethodsA modified CCWO was performed with Kirschner wires as osteotomy alignment aids. A juxta‐articular neutral wedge osteotomy equal in angle to the preoperative TPA was performed. Fixation was achieved with a tibial plateau leveling osteotomy (TPLO) plate and tension band wire apparatus (89%) or a TPLO plate (11%). Preoperative and postoperative, and recheck TPA, cranial tibial long axis shift, and major and minor complications were recorded.ResultsThe mean preoperative TPA (49.5° ± 6.7°) was reduced postoperatively (8.3° ± 4.8°). Four of 19 joints (21%) developed 2 major and 3 minor complications during the intraoperative and follow‐up period (577 day mean in‐hospital recheck). Two cases were diagnosed with surgical site infections requiring implant removal for resolution. Fixation failure or implant complications were not observed in any dog during the limited radiographic follow‐up period. All dogs were sound or recovering as expected, with 15/19 dogs (79%) showing complete radiographic osteotomy healing at their final in‐hospital follow‐up examination.ConclusionModified CCWO should be considered for the treatment of cranial cruciate ligament disease in dogs with eTPA. In this case series, the described technique was associated with uneventful osteotomy healing without implant failures in all dogs, although radiographic follow‐up was limited in some cases.
Konflik Kerja-Keluarga Dalam Kalangan Pensyarah: Satu Tinjauan
Authors: Chew Abdullah Nor Azimah 
Published: February 2017

The main objective of this study was to explore the relationships between work-family conflict, job involvement and family involvement among lecturers from the higher education institution in the northern region of Malaysia, who had child under the age of seventeen and below. The sample size was 151 respondents. Respondents were later classified into 97 male lecturers (64.2%) and 54 female lecturers (35.8%). Data was collected using questionnaires. Data analysis was done using descriptive statistics, t-test, Pearson correlation and regression. The Pearson correlations showed that job involvement and family involvement were not highly correlated with work-family conflict. The t-test also showed no significant differences between male and female lecturers in work-family conflict. Job involvement and family involvement do not explained the variation in work-family conflict.
Konsepsual Model Bagi Mengukur Kualiti Perkhidmatan Perpustakaan Akademik
Authors: Taib Che Azlan 
Published: February 2017

The Ninth Malaysia Plan (RMK-9) is the second phase of a national mission to achieve Vision 2020. The Eleventh Malaysia Plan (RMK-11), 2016-2020, is the latest five-year development plan towards realizing Vision 2020. One of the core the main is to increase knowledge and innovation and nurture first class mentality among Malaysians. Higher Education Institutions (HEIs) have a big responsibility to realize this vision. Thus, learning assessment instruments analyzed by Asif and Searcy should be improved to make it more comprehensive and relevant to current needs. For this purpose, an empirical study was conducted in which the data accessed across multiple groups of library user’s background from 5 HEIs (private and public) in the north of Peninsular Malaysia. This study involved 381 respondents as the sample. The reliability tests through 3 criteria displayed the internal consistencies of the seven factors were satisfactorily (α=0.70): Coefficient Alpha (CA), Corrected Item-Total Correlation (CITC) and Alpha if Item Deleted (IID). It shows all constructs have to comply with three criteria, namely CA, CITC and the IID. Meanwhile for the content validity views of experts was conducted. All comments have been improved before final questionnaire distributed. As a conclusion, the result indicated that the model was highly goodness fit for measuring library services, and all dimensional constructs supported the proposed theoretical model.
Thyroid Ultrasound: State of the Art Part 1 – Thyroid Ultrasound reporting and Diffuse Thyroid Diseases
Authors: Dighe Manjiri , Barr Richard , Bojunga Jörg , Cantisani Vito , Chammas Maria Cristina , Cosgrove David , Cui Xin Wu , Dong Yi , Fenner Franziska , Radzina Maija , Vinayak Sudhir , Xu Jun Mei , Dietrich Christoph F 
Published: February 2017

Accurate differentiation of focal thyroid nodules (FTL) and thyroid abnormalities is pivotal for proper diagnostic and therapeutic work-up. In these two part articles, the role of ultrasound techniques in the characterization of FTL and evaluation of diffuse thyroid diseases is described to expand on the recently published World Federation in Ultrasound and Medicine (WFUMB) thyroid elastography guidelines and review how this guideline fits into a complete thyroid ultrasound exam.
Periodontitis in early and chronic rheumatoid arthritis: a prospective follow-up study in Finnish population
Authors: Äyräväinen Leena , Leirisalo-Repo Marjatta , Kuuliala Antti , Ahola Kirsi , Koivuniemi Riitta , Meurman Jukka H , Heikkinen Anna Maria 
Published: February 2017

ObjectivesTo investigate the association between rheumatoid arthritis (RA) and periodontitis with special emphasis on the role of antirheumatic drugs in periodontal health.DesignProspective follow-up study. Patients with early untreated RA and chronic active RA were examined at baseline and 16 months later. Controls were examined once.Settings and participantsThe study was conducted in Finland from September 2005 to May 2014 at the Helsinki University Hospital. Overall, 124 participants were recruited for dental and medical examinations: 53 were patients with early disease-modifying antirheumatic drug (DMARD) naїve RA (ERA), 28 were patients with chronic RA (CRA) with insufficient response to conventional DMARDs. After baseline examination, patients with ERA started treatment with synthetic DMARDs and patients with CRA with biological DMARDs. Controls were 43 age-matched, gender-matched and community-matched participants.Outcome measuresDegree of periodontitis (defined according to the Center for Disease Control and Prevention and the American Academy of Periodontology). Prevalence of periodontal bacteria (analysed from plaque samples), clinical rheumatological status by Disease Activity Score, 28-joint count (DAS28), function by Health Assessment Questionnaire (HAQ) and treatment response by European League Against Rheumatism (EULAR) criteria.ResultsModerate periodontitis was present in 67.3% of patients with ERA, 64.3% of patients with CRA and 39.5% of control participants (p=0.001). Further, patients with RA had significantly more periodontal findings compared with controls, recorded with common periodontal indexes. In the re-examination, patients with RA still showed poor periodontal health in spite of treatment with DMARDs after baseline examination. The prevalence ofPorphyromonas gingivaliswas higher in patients with ERA with periodontal probing depth ≥4 mm compared with patients with CRA and controls. Antirheumatic medication did not seem to affect the results.ConclusionsModerate periodontitis was more frequent in patients with RA than in controls. Patients with ERA and CRA exhibited poorer periodontal health parameters when compared with controls. There was no association between antirheumatic treatment and periodontal parameters.
Generalized pairing strategies-a bridge from pairing strategies to colorings
Authors: Győrffy Lajos , Pluhár András 
Published: February 2017

Abstract
In this paper we define a bridge between pairings and colorings of the hypergraphs by introducing a generalization of pairs called t-cakes for t ∈ ℕ, t ≥ 2. For t = 2 the 2-cakes are the same as the well-known pairs of system of distinct representatives, that can be turned to pairing strategies in Maker-Breaker hypergraph games, see Hales and Jewett [12]. The two-colorings are the other extremity of t-cakes, in which the whole ground set of the hypergraph is one big cake that we divide into two parts (color classes). Starting from the pairings (2-cake placement) and two-colorings we define the generalized t-cake placements where we pair p elements by q elements (p, q ∈ ℕ, 1 ≤ p, q < t, p + q = t).
The method also gives bounds on the condition of winnings in certain biased Chooser-Picker games, which can be introduced similarly to Beck [3]. We illustrate these ideas on the k-in-a-row games for different values of k on the infinite chessboard.
Some Hermite-Hadamard type integral inequalities for operator AG-preinvex functions
Authors: Taghavi Ali , Nazari Haji Mohammad , Darvish Vahid 
Published: February 2017

AbstractIn this paper, we introduce the concept of operator AG-preinvex functions and prove some Hermite-Hadamard type inequalities for these functions. As application, we obtain some unitarily invariant norm inequalities for operators.
Specifying temporal knowledge for workflows
ontologies
Authors: Plesniewicz Gerald , Karabekov Baurzhan 
Published: February 2017

Abstract
A workflow is an automation of a process, in
which participants (people or programs) are involved in
activities for solving a set of tasks according to certain
rules and constraints in order to attain a common goal.
The concept of workflow appeared in business informatics.
Currently the workflow techniques are used in many
other fields such as medical informatics, bioinformatics,
automation of scientific research, computer-aided design
and manufacturing, etc. An ontology is a formal description
(in terms of concepts, entities, their properties and relationships)
of knowledge for solving a given class of problems.
In particular, ontologies can be used in problems related
to workflows. In this paper, we introduce a formalism
that extends the language of the interval Allen’s logic,
and show how this formalism can be applied to specify
temporal knowledge in ontologies for workflows. For the
extended Allen’s logic, we construct a deduction system
based on the analytic tableaux method. We also show (by
examples) how to apply the deduction method to query
answering over ontologies written in the extended Allen’s
logic.
GUW-7 and KW-2 igniters types in the long-time storage process
Authors: Ampuła Dariusz 
Published: February 2017

Abstract
A statistical analysis of multiyear test results of GUW-7 and KW-2 artillery igniters type is presented in this article as representative ones to examine natural ageing process influence on indicators of quality during long-time storage. The influence of storage time on decisions connected with the quality of the lots after tests and on inconsistencies characterising the advancement level of the natural ageing process were analysed. The influence analysis of testing cycles on occurrence of inconsistences in definite classes and for the next quality decisions were carried out. The performed analysis can be essential for tests methodology of artillery igniters relevant modifications.
Rebuilding Nepal for next earthquake
Authors: Nyachhyon B. L. 
Published: February 2017

Rebuilding Nepal for next earthquakeABSTRACTThe paper is prepared to draw attention of local and international community including the government and donors to gear up for policy reform and create an environment for investing in proactive earthquake safety initiatives before the next earthquake strikes. The paper focuses on the outcome of the author’s continuous interaction with local community since 1985 on the need for extended earthquake safety initiatives through stakeholders’ easy access to technical assistance and financial resources. The most neglected aspect in the earthquake initiatives of Nepal is the lack of state ownership and lack of dedicated responsible institutions resulting in a massive toll of life and property. It is time to use the opportunity created by the April 2015 earthquake.Keywords: policy reform; proactive initiatives; conservation; strengthening. Reconstruyendo Nepal para el siguiente terremotoRESUMENEl documento está preparado para llamar la atención de la comunidad local e internacional, incluyendo el gobierno y los donantes, para prepararse para la reforma de políticas y crear un ambiente para invertir en iniciativas proactivas de seguridad ante terremotos antes del próximo terremoto. El documento se centra en los resultados de la interacción continua del autor con la comunidad local desde 1985 sobre la necesidad de ampliar las iniciativas de seguridad de terremotos a través del fácil acceso de los interesados a asistencia técnica y recursos financieros. El aspecto más desatendido en las iniciativas con respecto a terremotos en Nepal es la falta de propiedad estatal y de instituciones responsables, lo que da lugar a un gran número de pérdida de vidas y bienes. Ya es hora de utilizar la oportunidad creada por el terremoto de abril de 2015.Palabras clave: reforma de políticas; iniciativas proactivas; conservación; fortalecimiento.Reconstruindo Nepal para o próximo terremotoRESUMOO documento é preparado para chamar a atenção da comunidade local e internacional, incluindo o governo e os doadores, para se preparar para a reforma das políticas e criar um ambiente de investir em proativo de segurança iniciativas terremoto antes do próximo terremoto. O documento centra-se nos resultados de uma interação contínua do autor com a comunidade local desde 1985 sobre a necessidade de ampliar as iniciativas de segurança terremotos através de fácil acesso das partes interessadas a assistência técnica e recursos financeiros. O aspecto mais negligenciado em iniciativas relativas aos terremotos no Nepal é a falta de instituições estatais e responsáveis, o que leva a um grande número de perda de vidas e bens. É hora de aproveitar a oportunidade criada pelo terremoto em abril de 2015.
Leveraging the Value of Human Relationships to Improve Health Outcomes
Authors: Kasthurirathne Suranga , Mamlin Burke , Cullen Theresa 
Published: February 2017

SummaryObjectives: Despite significant awareness on the value of leveraging patient relationships across the healthcare continuum, there is no research on the potential of using Electronic Health Record (EHR) systems to store structured patient relationship data, or its impact on enabling better health-care. We sought to identify which EHR systems supported effective patient relationship data collection, and for systems that do, what types of relationship data is collected, how this data is used, and the perceived value of doing so.Materials and methods: We performed a literature search to identify EHR systems that supported patient relationship data collection. Based on our results, we defined attributes of an effective patient relationship model. The Open Medical Record System (OpenMRS), an open source medical record platform for underserved settings met our eligibility criteria for effective patient relationship collection. We performed a survey to understand how the OpenMRS patient relationship model was used, and how it brought value to implementers.Results: The OpenMRS patient relationship model has won widespread adoption across many implementations and is perceived to be valuable in enabling better health care delivery. Patient relationship information is widely used for community health programs and enabling chronic care. Additionally, many OpenMRS implementers were using this feature to collect custom relationship types for implementation specific needs.Conclusions: We believe that flexible patient relationship data collection is critical for better healthcare, and can inform community care and chronic care initiatives across the world. Additionally, patient relationship data could also be leveraged for many other initiatives such as patient centric care and in the field of precision medicine.
Cover Image, Volume 97, Issue 4
Authors: Xu Ting , Li Yan , Zeng Xiadong , Yang Xiaolu , Yang Yuanzhu , Yuan Shanshan , Hu Xiaochun , Zeng Jiarui , Wang Zhenzhen , Liu Qian , Liu Yuqing , Liao Hongdong , Tong Chunyi , Liu Xuanming , Zhu Yonghua 
Published: February 2017

The cover image, by Ting Xu et al., is based on the Research Article Isolation and evaluation of endophytic Streptomyces endus OsiSh‐2 with potential application for biocontrol of rice blast disease, DOI: 10.1002/jsfa.7841.
image
Biophysikalische Chemie: Leuchten nach dem Vorbild der Natur
Authors: Schramm Stefan , Weiss Dieter , Beckert Rainer 
Published: February 2017

AbstractBisher war unklar, wie die Lumineszenz von Glühwürmchen funktioniert, dabei ist der Mechanismus unter Lebewesen weit verbreitet. Bei der Aufklärung hilft ein chemisches Modellsystem – die chemilumineszenten 2‐Coumaranone.
Review on penetration and transport phenomena in porous media during slot die coating
Authors: Ding Xiaoyu , Harris Tequila A. L. 
Published: February 2017

ABSTRACTA distinctive field in the coatings industry is coating of porous media, which has broad applications including paper, textiles, electronics, filtration, and energy sectors. Fluid penetration is an important issue during direct coating of a liquid bead on porous media, which is driven by the pressure from an external flow field and the surface tension in the porous media. Generally, during the coating process, some level of penetration is desirable to obtain specific material properties, but inadequate or excessive penetration is detrimental. To help control the level of penetration, understanding relationships between operating parameters and penetration are highly desirable. In this article, the current state of academic research on modeling penetration in porous media during common coating processes, especially the slot die coating process, is reviewed. Specifically, the challenges, basic ideas, advantages, and disadvantages of macroscale, microscale, and pore‐network models on penetration in porous media are discussed. This article concludes with some recommendations for future work. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 1669–1680
Alternative realities: Explaining security in the Asia-Pacific
Authors: Beeson Mark 
Published: February 2017

AbstractThe central argument of this article is that constructivists in particular underestimate or even ignore the importance of the ‘real’ structural inheritance that shapes state (and the political elites that represent them) behaviour. Even though the future is indeterminate, some outcomes are decidedly more likely than others, especially where policymakers believe they inhabit a strategic universe of zero sum outcomes and where self-reliance and assertion remain important. I suggest that ‘critical realism’ offers a way of accounting for the institutional structures that shape international behaviour. The first half of this article makes the case for a critical realist approach. The second half illustrates the possible importance of this claim with reference to the contemporary geopolitics of the Asia-Pacific region.
Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells
Authors: Rivero-Hinojosa Samuel , Kang Sungyun , Lobanenkov Victor V. , Zentner Gabriel E. 
Published: February 2017

AbstractDespite sharing the same sequence specificity in vitro and in vivo, CCCTC-binding factor (CTCF) and its paralog brother of the regulator of imprinted sites (BORIS) are simultaneously expressed in germ cells. Recently, ChIP-seq analysis revealed two classes of CTCF/BORIS-bound regions: single CTCF target sites (1xCTSes) that are bound by CTCF alone (CTCF-only) or double CTCF target sites (2xCTSes) simultaneously bound by CTCF and BORIS (CTCF&BORIS) or BORIS alone (BORIS-only) in germ cells and in BORIS-positive somatic cancer cells. BORIS-bound regions (CTCF&BORIS and BORIS-only sites) are, on average, enriched for RNA polymerase II (RNAPII) binding and histone retention in mature spermatozoa relative to CTCF-only sites, but little else is known about them. We show that subsets of CTCF&BORIS and BORIS-only sites are occupied by several testis-specific transcriptional regulators (TSTRs) and associated with highly expressed germ cell-specific genes and histone retention in mature spermatozoa. We also demonstrate a physical interaction between BORIS and one of the analyzed TSTRs, TATA-binding protein (TBP)-associated factor 7-like (TAF7L). Our data suggest that CTCF and BORIS cooperate with additional TSTRs to regulate gene expression in developing male gametes and histone retention in mature spermatozoa, potentially priming certain regions of the genome for rapid activation following fertilization.