bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper(I) Bromide‐Dimethyl Sulfide‐Catalyzed Direct Sulfanylation of 4‐Hydroxycoumarins and 4‐Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch‐ On Sensing of Cadmium(II) Ion in Water
Authors: Paul Sanjay , Shrestha Rajeev , Edison T. N. J. I. , Lee Yong Rok , Kim Sung Hong 
Published: September 2016

AbstractAn efficient protocol for the direct sulfanylation of various 4‐hydroxycoumarins and 4‐hydroxyquinolinones in good yield with arylsulfonylhydrazides as sulfanylating agents was developed via copper(I) bromide⋅dimethyl sulfide‐catalyzed S–O, S–N bond cleavage and C–S cross‐coupling reactions. A highly selective fluorescence turning‐on sensing of cadmium(II) ions in water using the synthesized 3‐sulfanyl‐4‐hydroxycoumarin derivative was also investigated.magnified image
Efficient Hydrogenation of Nitrogen Heterocycles Catalyzed by Carbon‐Metal Covalent Bonds‐Stabilized Palladium Nanoparticles: Synergistic Effects of Particle Size and Water
Authors: Zhang Yu , Zhu Jie , Xia Yun‐Tao , Sun Xiao‐Tao , Wu Lei 
Published: September 2016

AbstractWe reveal here the first hydrogenation of nitrogen heterocycles catalyzed by carbon–metal covalent bonds‐stabilized palladium nanoparticles in water under mild conditions. Using a one‐phase reduction method, smaller metal–carbon covalent bond‐stabilized Pd nanoparticles were prepared with a size distribution of 2.5±0.5 nm, which showed extraordinary synergistic effects with water in the catalytic hydrogenation of nitrogen heterocycles. Water was supposed to accelerate substrate absorption and synergistic activation of molecular hydrogen on the Pd nanoparticles surface. The nanosized Pd catalyst could be easily recovered and reused for 5 runs.magnified image
Downstream Processing of Nucleoside‐Diphospho‐Sugars from Sucrose Synthase Reaction Mixtures at Decreased Solvent Consumption
Authors: Lemmerer Martin , Schmölzer Katharina , Gutmann Alexander , Nidetzky Bernd 
Published: September 2016

AbstractNucleoside‐diphospho‐sugars (NDP‐sugars) are highly demanded as specialty chemicals and as substrates for enzymatic glycosylations. Biocatalysis is efficient for their synthesis; however, downstream processing (DSP) is a bottleneck of the overall production. We describe two scalable DSP routes for recovery of NDP‐glucose (NDP‐glc) from sucrose synthase (SuSy) reaction mixtures. In both routes product precipitation with ethanol replaced size exclusion chromatography (SEC) which, due to high solvent consumption, constitutes the main limiting step of current DSP protocols. We also show that selective phosphomonoester hydrolysis by alkaline phosphatase, characterized in that it did not degrade the phosphodiester linkage in NDP‐glc, was a useful alternative to anion‐exchange chromatography (AEC) for capture and initial purification of the product. Based on comprehensive route optimization, we show uridine 5′‐diphosphate glucose (UDP‐glc) recovery at the ≥0.5 g scale in a yield of about 80% and in a purity of 86% (phosphatase route) and 95% (AEC route). Solvent savings of up to 38‐fold compared to the conventional AEC‐SEC route were achieved. There is a clear demand for both new routes, as requirements on DSP regarding purity and costs vary with the field of application. Both DSP routes seem to be applicable to other NDP‐sugars and different methods of their synthesis.magnified image
A novel missense mutation of CMT2P alters transcription machinery
Authors: Hu Bo , Arpag Sezgi , Zuchner Stephan , Li Jun 
Published: September 2016

ObjectiveCharcot–Marie–Tooth type 2P (CMT2P) has been associated with frameshift mutations in the RING domain of LRSAM1 (an E3 ligase). This study describes families with a novel missense mutation of LRSAM1 gene and explores pathogenic mechanisms of CMT2P.MethodsPatients with CMT2P were characterized clinically, electrophysiologically, and genetically. A neuronal model with the LRSAM1 mutation was created using CRISPR/Cas9 technology. The neuronal cell line along with fibroblasts isolated from the patients was used to study RNA‐binding proteins.ResultsThis American family with dominantly inherited axonal polyneuropathy reveals a phenotype similar to those in previously reported non‐US families. The affected members in our family cosegregated with a novel missense mutation Cys694Arg that alters a highly conserved cysteine in the RING domain. This mutation leads to axonal degeneration in the in vitro neuronal cell line. Moreover, using protein mass spectrometry, we identified a group of RNA‐binding proteins (including FUS, a protein critically involved in motor neuron degeneration) that interacted with LRSAM1. The interactions were disrupted by the Cys694Arg mutation, which resulted in reduction of intranuclear RNA‐binding proteins.InterpretationOur findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery. Given that a similar mechanism has been reported in motor neuron degeneration of amyotrophic lateral sclerosis, abnormalities of RNA/RNA‐binding protein complex may play a role in the neuronal degeneration of CMT2P. Ann Neurol 2016;80:834–845
Synthese, Charakterisierung und Anwendungen von Metall‐Nanopartikeln nach Fixierung auf N‐dotiertem Kohlenstoff: Katalyse jenseits der Elektrochemie
Authors: He Lin , Weniger Florian , Neumann Helfried , Beller Matthias 
Published: September 2016

AbstractMetall‐Nanopartikel, die auf N‐dotierten Kohlenstoffmaterialien fixiert wurden, haben sich als neuartige Katalysatoren für verschiedene organische Umwandlungen herausgestellt. In diesem Kurzaufsatz werden Strategien für die Synthese von auf N‐dotiertem Kohlenstoff fixierten Metallkompositen und ihre Charakterisierung nach neuestem Stand der Technik beschrieben. Die katalytischen Anwendungen dieser faszinierenden Materialien für industriell relevante Reaktionen wie Oxidationen, Hydrierungen, die Fischer–Tropsch‐Synthese und die H2‐Entwicklung werden zusammengefasst. Zudem werden die Auswirkungen eines N‐Einbaus in die verschiedenen katalytischen Systeme verdeutlicht.
Aligned MoOx/MoS2 Core–Shell Nanotubular Structures with a High Density of Reactive Sites Based on Self‐Ordered Anodic Molybdenum Oxide Nanotubes
Authors: Jin Bowen , Zhou Xuemei , Huang Li , Licklederer Markus , Yang Min , Schmuki Patrik 
Published: September 2016

AbstractThe present work demonstrates the self‐organized formation of anodic molybdenum oxide nanotube arrays. The amorphous tubes can be crystallized to MoO2 or MoO3 and be converted fully or partially into molybdenum sulfide. Vertically aligned MoOx/MoS2 nanotubes can be formed when, under optimized conditions, defined MoS2 sheets form in a layer by layer arrangement that provide a high density of reactive stacking misalignments (defects). These core–shell nanotube arrays consist of a conductive suboxide core and a functional high defect density MoS2 coating. Such structures are highly promising for applications in electrocatalysis (hydrogen evolution) or ion insertion devices.
Manganese(I)‐Catalyzed C−H Activation: The Key Role of a 7‐Membered Manganacycle in H‐Transfer and Reductive Elimination
Authors: Yahaya Nasiru P. , Appleby Kate M. , Teh Magdalene , Wagner Conrad , Troschke Erik , Bray Joshua T. W. , Duckett Simon B. , Hammarback L. Anders , Ward Jonathan S. , Milani Jessica , Pridmore Natalie E. , Whitwood Adrian C. , Lynam Jason M. , Fairlamb Ian J. S. 
Published: September 2016

AbstractManganese‐catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven‐membered MnI intermediate is detected and characterized that is effective for H‐transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnI by judicious choice of an electron‐deficient 2‐pyrone substrate containing a 2‐pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry.
Construction of Quaternary Stereocenters by Nickel‐Catalyzed Heck Cyclization Reactions
Authors: Desrosiers Jean‐Nicolas , Hie Liana , Biswas Soumik , Zatolochnaya Olga V. , Rodriguez Sonia , Lee Heewon , Grinberg Nelu , Haddad Nizar , Yee Nathan K. , Garg Neil K. , Senanayake Chris H. 
Published: September 2016

AbstractA nickel‐catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3‐disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active molecules. The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means to construct stereochemically complex frameworks by nonprecious‐metal catalysis.
Two‐Dimensional Mesoscale‐Ordered Conducting Polymers
Authors: Liu Shaohua , Zhang Jian , Dong Renhao , Gordiichuk Pavlo , Zhang Tao , Zhuang Xiaodong , Mai Yiyong , Liu Feng , Herrmann Andreas , Feng Xinliang 
Published: September 2016

AbstractDespite the availability of numerous two‐dimensional (2D) materials with structural ordering at the atomic or molecular level, direct construction of mesoscale‐ordered superstructures within a 2D monolayer remains an enormous challenge. Here, we report the synergic manipulation of two types of assemblies in different dimensions to achieve 2D conducting polymer nanosheets with structural ordering at the mesoscale. The supramolecular assemblies of amphipathic perfluorinated carboxylic acids and block co‐polymers serve as 2D interfaces and meso‐inducing moieties, respectively, which guide the polymerization of aniline into 2D, free‐standing mesoporous conducting polymer nanosheets. Grazing‐incidence small‐angle X‐ray scattering combined with various microscopy demonstrates that the resulting mesoscale‐ordered nanosheets have hexagonal lattice with d‐spacing of about 30 nm, customizable pore sizes of 7–18 nm and thicknesses of 13–45 nm, and high surface area. Such template‐directed assembly produces polyaniline nanosheets with enhanced π–π stacking interactions, thereby resulting in anisotropic and record‐high electrical conductivity of approximately 41 S cm−1 for the pristine polyaniline nanosheet based film and approximately 188 S cm−1 for the hydrochloric acid‐doped counterpart. Our moldable approach creates a new family of mesoscale‐ordered structures as well as opens avenues to the programmed assembly of multifunctional materials.
Generation of Sulfonyl Radicals from Aryldiazonium Tetrafluoroborates and Sulfur Dioxide: The Synthesis of 3‐Sulfonated Coumarins
Authors: Zheng Danqing , Yu Jiyao , Wu Jie 
Published: September 2016

AbstractA catalyst‐free approach for the generation of sulfonyl radicals from aryldiazonium tetrafluoroborates in the presence of DABCO⋅(SO2)2 is realized. The combination of aryldiazonium tetrafluoroborates, DABCO⋅(SO2)2, and aryl propiolates affords 3‐sulfonated coumarins in good to excellent yields. This tandem reaction process involves radical addition, spirocyclization, and 1,2‐migration of esters. Additionally, the in situ diazotization of a number of anilines allows the directional synthesis of desired 3‐sulfonated coumarins in a one‐pot, two‐step process.
Synthesis, Characterization, and Application of Metal Nanoparticles Supported on Nitrogen‐Doped Carbon: Catalysis beyond Electrochemistry
Authors: He Lin , Weniger Florian , Neumann Helfried , Beller Matthias 
Published: September 2016

AbstractMetal nanoparticles deposited on N‐doped carbon materials have emerged as novel catalysts for various organic transformations. In this Minireview, strategies for the synthesis of metal composites on N‐doped carbon supports and their state‐of‐the‐art characterization are briefly described. The catalytic application of these fascinating materials in several industrially relevant reactions, including oxidations, hydrogenations, Fischer–Tropsch syntheses, and H2generation, is also summarized. Furthermore, the effects of nitrogen incorporation on the different catalytic systems are highlighted.
The effect of solvent on postcuring in free radical photopolymerization
Authors: Zhang Huijing , Nie Jun , Muhyodin Ghulam , Zhu Xiaoqun 
Published: September 2016

ABSTRACTDuring free radical photopolymerization, with an increasing degree of conversion, the viscosity increased and vitrification occurred. The unreacted double bonds had difficulty diffusing to the reactive site in the vitrifying polymer. However, the free radicals generated in the vitrifying matrix could survive for a long time. Thus, the postcuring process occurred. In this study, free radical photopolymerization kinetics of methacrylate with or without solvent was investigated by real‐time FTIR, which was combined with a heating device. Results showed that without solvent, postcuring occurred only by heating at a higher temperature than the glass transition temperature of the polymer. However, with solvent, the postcuring occurred even at room temperature, where only a small amount of solvent was enough to cause postcuring. The lifespan of the free radicals inside the polymer was over 10 h. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44223.
Characterization of polyacrylonitrile, poly(acrylonitrile‐co‐vinyl acetate), and poly(acrylonitrile‐co‐itaconic acid) based activated carbon nanofibers
Authors: Faraji Sahand , Yardim M. Ferhat , Can Dilek Suadiye , Sarac A. Sezai 
Published: September 2016

ABSTRACTIn this study, three different acrylonitrile (AN)‐based polymers, including polyacrylonitrile (PAN), poly(acrylonitrile‐co‐vinyl acetate) [P(AN‐co‐VAc)], and poly(acrylonitrile‐co‐itaconic acid) [P(AN‐co‐IA)], were used as precursors to synthesize activated carbon nanofibers (ACNFs). An electrospinning method was used to produce nanofibers. Oxidative stabilization, carbonization, and finally, activation through a specific heating regimen were applied to the electrospun fibers to produce ACNFs. Stabilization, carbonization, and activation were carried out at 230, 600, and 750 °C, respectively. Scanning electron microscopy, thermogravimetric analysis (TGA), and porosimetry were used to characterize the fibers in each step. According to the fiber diameter variation measurements, the pore extension procedure overcame the shrinkage of the fibers with copolymer precursors. However, the shrinkage process dominated the scene for the PAN homopolymer, and this led to an increase in the fiber diameter. The 328 m2/g Brunauer–Emmett–Teller surface area for ACNFs with PAN precursor were augmented to 614 and 564 m2/g for P(AN‐co‐VAc) and P(AN‐co‐IA), respectively. The TGA results show that the P(AN‐co‐IA)‐based ACNFs exhibited a higher thermal durability in comparison to the fibers of PAN and P(AN‐co‐VAc). The application of these copolymers instead of AN homopolymer enhanced the thermal stability and increased the surface area of the ACNFs even in low‐temperature carbonization and activation processes. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44381.
The influence of paraffin wax addition on the isothermal crystallization of LLDPE
Authors: Gumede Thandi P. , Luyt Adriaan S. , Pérez‐Camargo Ricardo A. , Müller Alejandro J. 
Published: September 2016

ABSTRACTThe influence of paraffin wax addition on the isothermal crystallization kinetics of linear low density polyethylene (LLDPE) was studied in a temperature range where the wax was always in the molten state and could be considered a solvent for LLDPE. The LLDPE/wax blends were prepared by melt mixing in the following compositions: 100/0, 95/5, 90/10, 80/20, 70/30, and 60/40. The results obtained show that the rate of isothermal crystallization is depressed by wax addition at constant crystallization temperatures. LLDPE needs a higher amount of supercooling to start crystallizing as the content of wax increases in the blends. The Flory–Huggins theory (FH) for polymer/diluent mixtures was applied employing equilibrium melting temperature values obtained by extrapolation with the Hoffman–Weeks method. The results of the FH analysis indicate that the interactions between wax and LLDPE are nonlinear and strongly depend on composition. This nonlinear composition dependence of wax/LLDPE interactions is reflected in the complex way in which the overall crystallization kinetics rate depends on both supercooling and composition. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44398.
Development of dieldrin, endosulfan, and hexachlorobenzene‐imprinted polymers for dye‐displacement array sensing
Authors: Silverio Ofelia V. , So Regina C. , Elnar Katrina Jean S. , Malapit Christian A. , Nepomuceno Ma. Cristine M. 
Published: September 2016

ABSTRACTDue to the toxicity associated with the exposure to organochlorine pesticides, new materials capable of selectively capturing and detecting these compounds are highly desirable. In this study, imprinted polymers were prepared using three organochlorine pesticides—dieldrin (DE), endosulfan (EN), or hexachlorobenzene (HCB) as templates. The MIPs were polymerized via precipitation polymerization. The yields were over 90% with particle sizes ranging from 62 to 214 nm. Binding studies combined with GC‐ECD analysis showed that each template is more selective to its corresponding MIP compared with the other two structurally homologous templates. These results were consistent with those obtained using UV–vis where more bromocresol green (BCG) dye was released when higher template concentrations were introduced to the corresponding BCG‐impregnated MIPs. Since unique selectivity response pattern for each of the MIPs was obtained, this demonstrated that the MIPs were selective and can be potentially used in dye‐displacement array sensing. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44401.
Altered Mitochondrial Anatomy of Trigeminal Ganglia Neurons in Diabetes
Authors: Rusu M.C. , Mănoiu V.S. , Vrapciu A.D. , Hostiuc S. , Mirancea N. 
Published: September 2016

ABSTRACTNeurons from sensory ganglia are exposed to oxidative attack in diabetes. Altered mitochondrial morphologies are due to impaired dynamics (fusion, fission) and to cristae remodeling. This study aimed to evaluate using transmission electron microscopy mitochondrial changes in diabetic trigeminal ganglia suggestive for ignition of apoptosis, in absence of “classical” morphological signs of apoptosis. We used samples of trigeminal ganglia (from six type 2 diabetes human donors and five streptozotocin (STZ)‐induced diabetic rats). In human diabetic samples we found three main distributions of mitochondria: (a) small “dark” normal mitochondria, seemingly resulted from fission processes; (b) small “dark” damaged mitochondria, with side‐vesiculations (single‐ and double‐coated), large matrix vesicles and cytosolic leakage of reactive species, mixed with larger “light” mitochondria, swollen, and with crystolysis; (c) prevailing “light” mitochondria. In STZ‐treated rats a type (c) distribution prevailed, except for nociceptive neurons where we found a different distribution: large and giant mitochondria, suggestive for impaired mitochondrial fission, mitochondrial fenestrations, matrix vesicles interconnected by lamellar cristae, and mitochondrial leakage into the cytosol. Thus, the ultrastructural pattern of mitochondria damage in diabetic samples of sensory neurons may provide clues on the initiation of intrinsic apoptosis, even if the classical morphological signs of apoptosis are not present. Further studies, combining use of biochemical and ultrastructural techniques, may allow a better quantification of the degree in which mitochondrial damage, with membrane alterations and cytosolic leaks, may be used as morphological signs suggesting the point‐of‐no return for apoptosis. Anat Rec, 299:1561–1570, 2016. © 2016 Wiley Periodicals, Inc.
Identification of Endocrine Disrupting Chemicals using a Virus‐Based Colorimetric Sensor
Authors: Moon Jong‐Sik , Lee Yujin , Shin Dong‐Myeong , Kim Chuntae , Kim Won‐Geun , Park Minji , Han Jiye , Song Hyerin , Kim Kyujung , Oh Jin‐Woo 
Published: September 2016

AbstractA simple and portable colorimetric sensor based on M13 bacteriophage (phage) was devised to identify a class of endocrine disrupting chemicals, including benzene, phthalate, and chlorobenzene derivatives. Arrays of structurally and genetically modified M13 bacteriophage were fabricated so as to produce a biomimetic colorimetric sensor, and color changes in the phage arrays in response to several benzene derivatives were characterized. The sensor was also used to classify phthalate and chlorobenzene derivatives as representatives of endocrine disrupting chemicals. The characteristic color patterns obtained on exposure to various benzene derivatives enabled similar chemical structures in the vapor phase to be classified. Our sensing approach based on the use of a genetically surface modified M13 bacteriophage offers a promising platform for portable, simple environmental monitors that could be extended for use in numerous application areas, including food monitoring, security monitoring, explosive risk assessment, and point of care testing.
Homogeneous Control of Pneumatic Cylinders Based on Time Delay Model and Artstein Transformation
Authors: Edjekouane E. , Riachy S. , Ghanes M. , Barbot J.‐P. 
Published: September 2016

AbstractIn this paper, an experimental second order model with time delay is considered in order to design a robust control of pneumatic cylinders. This model is derived by using the well known Strejc identification method. The design of the proposed homogeneous control law is synthesized thanks to Artstein transformation which allows to deal with the delay on the input. Real‐time experimental tests and comparisons with some existing works are conducted to highlight the effectiveness of the proposed methodology.
Enzymatically prepared redox‐responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation
Authors: Moriyama Kousuke , Naito Shono , Wakabayashi Rie , Goto Masahiro , Kamiya Noriho 
Published: September 2016

AbstractCellular spheroids have been received much attention in the biological and biomedical fields, especially as a base material for drug assays, regenerative medicine, and tissue engineering. Hydrogels have potential for scalable preparation of spheroids because they provide a spatial environment suitable for three‐dimensional cell cultivation. Herein, the potential use of a redox‐responsive hydrogel as a scaffold for preparation and recovery of spheroids is reported. A hydrogel composed of poly(ethylene glycol) (PEG), which can be degraded using cysteine as a reducing agent under mild conditions, is prepared by mixing an octa‐thiolated PEG derivative (8‐arm PEG‐SH), horseradish peroxidase and a small phenolic compound (Glycyl‐L‐tyrosine). Human hepatocellular carcinoma cells (HepG2) are encapsulated in the hydrogel and cellular spheroids formed by proliferation within the scaffolds. After seven days of cultivation, the size of the HepG2 spheroids reached a diameter between ≈40 and 60 μm, depending on the 8‐arm PEG‐SH concentration. Liver‐specific functions of the HepG2 spheroids such as albumin secretion and urea production are retained at higher levels than those of cells prepared from traditional two‐dimensional mono layers. These results suggest that the system presented here has potential for preparation of cellular spheroids for tissue engineering applications.