bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A
Authors: Kahle Joerg , Orlowski Aleksander , Stichel Diana , Healey John F. , Parker Ernest T. , Jacquemin Marc , Krause Manuela , Tiede Andreas , Schwabe Dirk , Lollar Pete , Königs Christoph 
Published: May 2017

Key Points
The fVIII C1 domain contributes significantly to the immune response against fVIII in acquired and congenital hemophilia inhibitor patients. B-cell epitopes identified for monoclonal murine and human C1 inhibitors are recognized by antibodies present in patients with hemophilia.
A low-frequency deghosting method: Analysis and numerical tests
Authors: Wang Ying , Ramirez Adriana Citlali , Osen Are 
Published: May 2017

The low-frequency component of seismic data can be beneficial for several reasons: improved signal penetration into the earth, enhanced resolution, and better constrained inversion results. We have developed a detailed analysis of a deghosting solution for the low-frequency spectrum of marine seismic pressure data. The advantages of this low-frequency deghosting method are: (1) it can be applied in the spatial domain, (2) it is applicable for horizontal streamers and for streamers with a mild depth variation, and (3) it is a fast-track solution that can be used flexibly as a preprocessing, or premigration step. The disadvantages of this method are: (1) it is an approximation to the full-deghosting operator and cannot infill the ghost notches of the spectrum, except near 0 Hz, and (2) it has decreasing effectiveness with a larger source/receiver depth. Numerical tests on the synthetic and field data sets indicate that this method is promising in deghosting data, up to at least half the frequency of the first nonzero ghost notch.
Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
Authors: Kamalesh Kumari , Trivedi Deepti , Toscano Sarah , Sharma Sanjeev , Kolay Sourav , Raghu Padinjat 
Published: May 2017

ABSTRACT
Endocytic turnover is essential for the regulation of the protein composition and function of the plasma membrane, and thus affects the plasma membrane levels of many receptors. In Drosophila melanogaster photoreceptors, photon absorption by the G-protein-coupled receptor (GPCR) rhodopsin 1 (Rh1; also known as NinaE) triggers its endocytosis through clathrin-mediated endocytosis (CME). We find that CME of Rh1 is regulated by phosphatidylinositol 5 phosphate 4-kinase (PIP4K). Flies lacking PIP4K show mislocalization of Rh1 on expanded endomembranes within the cell body. This mislocalization of Rh1 was dependent on the formation of an expanded Rab5-positive compartment. The Rh1-trafficking defect in PIP4K-depleted cells could be suppressed by downregulating Rab5 function or by selectively reconstituting PIP4K in the PI3P-enriched early endosomal compartment of photoreceptors. We also found that loss of PIP4K was associated with increased CME and an enlarged Rab5-positive compartment in cultured Drosophila cells. Collectively, our findings define PIP4K as a novel regulator of early endosomal homeostasis during CME.
The impact of simulated motion blur on lesion detection performance in full-field digital mammography
Authors: Abdullah Ahmed K , Kelly Judith , Thompson John D , Mercer Claire E , Aspin Rob , Hogg Peter 
Published: May 2017

Objective:
Motion blur is a known phenomenon in full-field digital mammography, but the impact on lesion detection is unknown. This is the first study to investigate detection performance with varying magnitudes of simulated motion blur.

Methods:
7 observers (15 ± 5 years' reporting experience) evaluated 248 cases (62 containing malignant masses, 62 containing malignant microcalcifications and 124 normal cases) for 3 conditions: no blurring (0 mm) and 2 magnitudes of simulated blurring (0.7 and 1.5 mm). Abnormal cases were biopsy proven. Mathematical simulation was used to provide a pixel shift in order to simulate motion blur. A free-response observer study was conducted to compare lesion detection performance for the three conditions. The equally weighted jackknife alternative free-response receiver operating characteristic was used as the figure of merit. Test alpha was set at 0.05 to control probability of Type I error.

Results:
The equally weighted jackknife alternative free-response receiver operating characteristic analysis found a statistically significant difference in lesion detection performance for both masses [F(2,22) = 6.01, p = 0.0084] and microcalcifications [F(2,49) = 23.14, p &lt; 0.0001]. The figures of merit reduced as the magnitude of simulated blurring increased. Statistical differences were found between some of the pairs investigated for the detection of masses (0.0 vs 0.7 and 0.0 vs 1.5 mm) and all pairs for microcalcifications (0.0 vs 0.7, 0.0 vs 1.5 and 0.7 vs 1.5 mm). No difference was detected between 0.7 and 1.5 mm for masses.

Conclusion:
The mathematical simulation of motion blur caused a statistically significant reduction in lesion detection performance. These false-negative decisions could have implications for clinical practice.

Advances in knowledge:
This research demonstrates for the first time that motion blur has a negative and statistically significant impact on lesion detection performance in digital mammography.
Evaluation of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in pure mineral hydrocarbon-based cosmetics and cosmetic raw materials using 1H NMR spectroscopy
Authors: Lachenmeier Dirk W. , Mildau Gerd , Rullmann Anke , Marx Gerhard , Walch Stephan G. , Hartwig Andrea , Kuballa Thomas 
Published: May 2017

Mineral hydrocarbons consist of two fractions, mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). MOAH is a potential public health hazard because it may include carcinogenic polycyclic compounds. In the present study, 400 MHz nuclear magnetic resonance (NMR) spectroscopy was introduced, in the context of official controls, to measure MOSH and MOAH in raw materials or pure mineral hydrocarbon final products (cosmetics and medicinal products). Quantitative determination (qNMR) has been established using the ERETIC methodology (electronic reference to access in vivo concentrations) based on the PULCON principle (pulse length based concentration determination). Various mineral hydrocarbons (e.g., white oils, paraffins or petroleum jelly) were dissolved in deuterated chloroform. The ERETIC factor was established using a quantification reference sample containing ethylbenzene and tetrachloronitrobenzene. The following spectral regions were integrated: MOSH δ 3.0 – 0.2 ppm and MOAH δ 9.2 - 6.5, excluding solvent signals. Validation showed a sufficient precision of the method with a coefficient of variation <6% and a limit of detection <0.1 g/100 g. The applicability of the method was proven by analysing 27 authentic samples with MOSH and MOAH contents in the range of 90-109 g/100 g and 0.02-1.10 g/100 g, respectively. It is important to distinguish this new NMR-approach from the hyphenated liquid chromatography-gas chromatography methodology previously used to characterize MOSH/MOAH amounts in cosmetic products. For mineral hydrocarbon raw materials or pure mineral hydrocarbon-based cosmetic products, NMR delivers higher specificity without any sample preparation besides dilution. Our sample survey shows that previous methods may have overestimated the MOAH amount in mineral oil products and opens new paths to characterize this fraction. Therefore, the developed method can be applied for routine monitoring of consumer products aiming to minimize public health risks.
Node, Edge, Arc Routing and Turn Penalties: Multiple Problems—One Neighborhood Extension
Authors: Vidal Thibaut 
Published: May 2017

This article explores a structural neighborhood decomposition for arc routing problems, in which the decisions about traversal orientations during services are made optimally as part of neighbor evaluation procedures. Using memory structures, bidirectional dynamic programming, and lower bounds, we show that a large neighborhood involving classical moves on the sequences of services along with optimal orientation decisions can be searched in amortized O(1) time per move evaluation instead of O(n) as in previous works. Because of its generality and now-reduced complexity, this approach can be efficiently applied to several variants of arc routing problems, extended into large neighborhoods such as ejection chains, and integrated into two classical metaheuristics. Our computational experiments lead to solutions of high quality on the main benchmark sets for the capacitated arc routing problem (CARP), the mixed capacitated general routing problem (MCGRP), the periodic CARP, the multidepot CARP, and the min-max k-vehicles windy rural postman problem, with a total of 1,528 instances. We also report sensitivity analyses for new MCGRP instances with turn penalties, which are uncommonly challenging yet critical for many practical applications. The e-companion is available at https://doi.org/10.1287/opre.2017.1595
EXPERIENCIAS PEDAGÓGICAS: Estudio interdisciplinario y experiencia educativa sobre la alimentación Mocoví
Authors: Benzi Marina , Wicky Mariel , Camargo Ana , Escobar Yamila 
Published: May 2017

En el presente trabajo se pretende destacar tres acontecimientos que merecen ser conocidos y difundidos. Los mismos tuvieron lugar en la carrera de Lic. en Nutrición, FBCB, de la UNL. En primer lugar, la realización de la tesina de las licenciadas en Nutrición, Ana L. Camargo y Yamila A. Escobar sobre los hábitos alimentarios y de consumo en la población Mocoví Aim Mokoilek de Colonia Dolores, los cambios en las últimas décadas y relación con el estado nutricional actual. Por otro lado, en el transcurso del dictado de la materia de Socioantropología de la Alimentación del 2016, Ana Camargo ofrece una clase expositivasobre el trabajo de investigación, la cual aborda la cuestión alimentaria desde una mirada interdisciplinaria, y comparte con el alumnado su aprendizaje y vivencia respecto a cuestionesteóricas-metodológicas específicas de su proyecto. Para finalizar, es meritorio reflexionar el lugar de Ana Camargo desde la cuestión metodológica, ya que al pertenecer a la comunidad mocoví de Colonia Dolores, su rol como investigadora debe ser problematizado. Los sucesos imprimen en la formación de los docentes y el alumnado, un compromiso humanitario; porlo tanto, se logra rescatar valores y formas de vida de la comunidad mocoví en y desde el ámbito universitario.
INVESTIGACIONES EDUCATIVAS 87: Licenciatura en nutrición de la Universidad Nacional del Litoral: la mirada de sus graduados recientes
Authors: Paulini Rosario B. , Dezar Gimena V. 
Published: May 2017

El presente trabajo se sustenta en el reconocimiento de que los estudios de seguimiento de egresados constituyen una estrategia de investigación evaluativa de las instituciones de educación superior, en tanto permiten indagar sobre el impacto de la formación en los procesos de inserción, desarrollo profesional y personal de sus egresados.Este trabajo de investigación tiene como objetivos describir el perfil de los graduados de Licenciatura en Nutrición de la Facultad de Bioquímica y Ciencias Biológicas (FBCB); y la evaluación sobre la formación de grado recibida. Se realizó una investigación cuali-cuantitativa, de corte transversal, descriptiva e interpretativa. La población de estudio estuvo constituida por profesionales graduados de la Licenciatura en Nutrición de la FBCB-UNL, en el periodo 2010-2013.Se realizó un cuestionario que fue cargado en el programa Google Drive, y la modalidad para contestar on-line e individual.Respecto al perfil de los graduados existe un predominio del sexo femenino, y provienendel interior de la provincia de Santa Fe. La evaluación de los mismos sobre la formación de grado recibida fue positiva. Además volverían a elegir la carrera de Licenciatura en Nutrición, y se sienten orgullosos de ser egresados de esta casa de estudio.
The teachers’ role in the process of prevention child sexual abuse<p>Çocuk cinsel istismarını önleme sürecinde öğretmenlerin rolü
Authors: Küçük Sibel , Faydalı Saide , Yeşülyurt Maide 
Published: May 2017

Teachers who are in communication with the children along their professional life and could observe physical and behavioral changes have very important roles in determination of sexual abuse, legal and social process. This study was conducted to determine the knowledge of teachers about determination of child sexual abuse, legal and social process.The study was conducted with 331 voluntary teachers who work a city at Central Anatolia Region between September 2014 and February 2015. For statistical analysis; mean, percentage, chi-square tests were used.It is determined that the mean age of the teachers was 39.0±8.0; the most of them were men, married, worked at primary school first stage and as branch teacher. It is found that physical and sexual abuse were most known, while abuse symptoms and required approaches, first reporting office, punishment when not reporting, legal and social process were least known by the teachers. It is determined that teachers who are in the Guidance and Psychological Counseling (GPC) and have been previous educated, their knowledge on determination of child sexual abuse, legal and social process were significantly higher than the others. Extended English abstract is in the end of PDF (TURKISH) file. ÖzetProfesyonel yaşamları boyunca çocuklarla iletişim halinde olan, çocuktaki fiziksel ve davranışsal değişiklikleri gözlemleyebilen öğretmenler çocuk cinsel istismarının belirlenmesinde, adli ve sosyal süreçte önemli roller üstlenmektedir. Çalışma öğretmenlerin çocuk cinsel istismarının belirlenmesine, adli ve sosyal sürece ilişkin bilgilerini saptanmak amacıyla gerçekleştirilmiştir.Orta Anadolu’da bir şehirde çalışmaya gönüllü olarak katılan 331 öğretmenle Eylül 2014 - Şubat 2015 tarihleri arasında veriler toplanmıştır. Değerlendirmede ortalama, sayı, yüzde, ki-kare testleri kullanılmıştır.Öğretmenlerin yaş ortalamalarının 39.0±8.0, çoğunluğunun erkek, evli, lisans mezunu olduğu, ilköğretim I. kademede, branş öğretmeni olarak çalıştığı belirlenmiştir. En fazla fiziksel ve cinsel istismarın bilindiği, çocuk cinsel istismarı konusunda eğitim alma, istismarla karşılaşma, istismar belirtileri ve yapılması gerekenler, ilk ihbar makamı, istismarı bildirmeme durumundaki cezalar, adli ve sosyal süreç konularında bilgi düzeyinin düşük olduğu saptanmıştır. PDR branşında çalışma ve çocuk istismarına dair daha önce eğitim alma ile çocuk cinsel istismarını anlama, belirtilerini ve yapılması gerekenleri bilme arasındaki farkın istatistiksel olarak anlamlı olduğu belirlenmiştir (p=0.00).
Dancing manly men: Gender analaysis of experiements of male dancers<p>Dans eden “erkek adamlar”: Erkek dansçıların deneyimlerine toplumsal cinsiyet analizi
Authors: Kavasoğlu İrem , Rençbereli Merve , Yenel İbrahim Fatih 
Published: May 2017

Gendered nature of sports excludes women and also men in some sports. The patriarchal culture’s way of coding dance as a feminine act is creating some restrictions for men. The aim of this study is to examine the meaning and limits of being a male dancer in Adana. Datas were collected by semi-structured interviews using phemonologhy which is one of research methods of qualitative research method. The participants was constituted by 5 male dancer (salsa). Data were analyzed by the content analysis method. The findings of the data obtained from the analysis collected under three themes: 1 Masculine Norms: Does a man dance? 2 Humiliated femininity: Do not wiggle like a girl, 3 Homophobia: You look like a gay son, you have to wear this? As a result, a significant domination generated by the dominance over the body acts set by gender differences over male dancers was observed. The strategy to get rid of prejudice and oppression is to insist, to prove that they are successful and not to wear tights.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetSpor dallarının toplumsal cinsiyetlendirilmiş yapısı bazı sporlarda kadınları bazılarında ise erkekleri dışlamaktadır. Ataerkil kültürün dansı dişil bir edim olarak kodlaması, erkekler için bir takım kısıtlamalar yaratmaktadır. Bu çalışmanın amacı, Adana’da erkek dansçı olmanın anlam ve sınırlarını incelemektir. Nitel araştırma yöntemlerinden fenemonoloji yönteminin kullanıldığı araştırmanın verileri yarı yapılandırılmış görüşme yöntemi ile toplanmıştır. Araştırmanın katılımcılarını 5 erkek dansçı (salsa) oluşturmuştur. Veriler içerik analizi yöntemi ile analiz edilmiştir. Veri analizi sonucunda elde edilen bulgular 3 tema altında toplanmıştır: 1 Eril Normlar: Erkek adam dans eder mi? 2 Aşağılanan Kadınlık: Karı gibi kıvırtma, 3 Homofobi: Oğlum gey gibi olmuşsun bunu giymek zorunda mısın? Sonuç olarak, cinsiyet farklılıklarının bedenin edimleri üzerinde kurduğu hakimiyetin, erkek dansçılar üzerinde önemli bir tahakküm oluşturduğu görülmüştür. Dansçılar için önyargı ve baskıdan kurtulma stratejisi ise ısrarcı olmak, başarılı olduklarını ispat etmek ve tayt giymemektir.
Dichotomy of global capacity density in metric measure spaces
Authors: Aikawa Hiroaki , Björn Anders , Björn Jana , Shanmugalingam Nageswari 
Published: May 2017

Abstract
The variational capacity

cap
p

{\operatorname{cap}_{p}}

in Euclidean spaces is known to enjoy the
density dichotomy at large scales, namely that for every

E
⊂

ℝ
n

{E\subset{\mathbb{R}}^{n}}

,

inf

x
∈

ℝ
n

⁡

cap
p

⁡

(

E
∩

B
⁢

(
x
,
r
)

,

B
⁢

(
x
,

2
⁢
r

)

)

cap
p

⁡

(

B
⁢

(
x
,
r
)

,

B
⁢

(
x
,

2
⁢
r

)

)

\inf_{x\in{\mathbb{R}}^{n}}\frac{\operatorname{cap}_{p}(E\cap B(x,r),B(x,2r))}%
{\operatorname{cap}_{p}(B(x,r),B(x,2r))}

is either zero or tends to 1 as

r
→
∞

{r\to\infty}

.
We prove that this property still holds in unbounded
complete geodesic metric spaces equipped
with a doubling measure supporting a p-Poincaré inequality,
but that it can fail in nongeodesic metric spaces and also for the Sobolev
capacity in

ℝ
n

{{\mathbb{R}}^{n}}

.
It turns out that
the shape of balls impacts the validity of the density dichotomy.
Even in more general metric spaces, we construct families of sets, such as
John domains, for which the density dichotomy holds.
Our arguments include an exact formula for the variational capacity of
superlevel sets for capacitary potentials
and a quantitative approximation from inside of
the variational capacity.
Actively managed products: Think-aloud data and methods in applied linguistics research
Authors: Deschambault Ryan 
Published: May 2017

AbstractVerbal reports, specifically in the form of concurrent verbalizations (i.e., think-alouds [TAs]), have played a foundational role in the production of knowledge in applied linguistics. Most often drawn upon because the talk they generate is deemed to accurately reflect individual learners’ thought or cognitive processes as they complete an L2 task, concurrent verbalization methods have been central to investigations of and claims about the learning, use, and assessment of L2 vocabulary, listening, speaking, reading, and writing (among others). And although critical discussion concerning the quality of spoken data obtained through concurrent verbalization methods continues among L2 researchers (e.g., Cohen, Andrew D. 1987. Using verbal reports in research on language learning. In Claus Færch & Gabriele Kasper (eds.),Introspection in second language research, 82–95. Philadelphia: Multilingual Matters; Cohen, Andrew D. 1996. Verbal reports as a source of insights into second language learner strategies.Applied Language Learning7(1–2). 5–24; Cohen, Andrew D. 2013. Verbal report. In Carol A. Chapelle (ed.),The encyclopedia of applied linguistics. Oxford: Wiley-Blackwell), the majority of this discussion has focused primarily on how best to generate talk which “more accurately reflect[s] the actual thought processes” of L2 users (Cohen, Andrew D. 2013. Verbal report. In Carol A. Chapelle (ed.),The encyclopedia of applied linguistics. Oxford: Wiley-Blackwell: 1). The result has been to further naturalize approaches to concurrent verbalizations which treat language as a neutral means for accessing cognition, and similarly, which treat the verbalizations themselves as individually accomplished events. In this article, my aim is to diversify the critical discussion by describing how discursive psychology (e.g., Edwards, Derek & Jonathan Potter. 1992.Discursive psychology. New York: Sage; Potter, Jonathan. 2006. Cognition and conversation.Discourse Studies8(1). 131–140) and a conversation analytic perspective (e.g., Kasper, Gabriele. 2009. Locating cognition in second language interaction and learning: Inside the skull or in public view?International Review of Applied Linguistics47. 11–36; Markee, Numa & Mi-Suk Seo. 2009. Learning talk analysis.International Review of Applied Linguistics47. 37–63) can be combined to present an alternative to both ‘naturalized’, as well as sociocultural, understandings of concurrent verbalization data and methods. To this end, after establishing some of the key differences between information processing, sociocultural, and discursive approaches, I draw on data from two recently published TA-based studies in an attempt to accomplish two goals: the first is to shift critical discussion towards issues of epistemology, methodology, and research representation, and the second is to identify methodological issues about which researchers working from different conceptual orientations might engage in cross-paradigmatic dialogue.
Two new epizoic Achnanthes species (Bacillariophyta) living on marine turtles from Costa Rica
Authors: Majewska Roksana , De Stefano Mario , Ector Luc , Bolaños Federico , Frankovich Thomas A. , Sullivan Michael J. , Ashworth Matt P. , Van de Vijver Bart 
Published: May 2017

AbstractIt has been known for a long time that marine mammals, such as whales and dolphins, host a very specific epizoic community on their skin. Whether or not a similar community exists on the carapaces of sea turtles is less studied. The present paper describes two new epizoic diatoms from the genus
Intellectual Property Rights, Foreign Direct Investment and Economic Freedom
Authors: Saravia Antonio , Canavire-Bacarreza Gustavo J. , Rios-Avila Fernando 
Published: May 2017

Abstract: The relationship between intellectual property rights (IPR) protection and foreign direct investment (FDI) continues to pose a challenging puzzle. While several studies have found that these two variables are positively correlated, others have not been able to find conclusive results. We contend that a partial explanation resides on institutional differences among host countries. We find that increases in IPR protection encourage FDI in countries in which the institutional environment, as proxied by indices of economic freedom, is efficient but not otherwise. We use threshold regression techniques on samples ranging from 81 to 102 countries during the 1990 - 2010 period.
Time Series Data Storage System Based on Big Data Technologies: Architecture and Implementation
Authors: Wu Kehe , Zhu Yayun , Chen Zuge 
Published: May 2017

AbstractA steady usage growth of various smart meters/sensors types comes along with the development of Smart Grid. Due to that smart meters/sensors usually produce data continuously, the state-of-the-art storage architecture will no longer be sustainable under such a dramatic data increase circumstance. It is crucial that these data shall be stored for both short and long term analysis to seek valuable information. This paper proposed a scalable and distributed storage architecture for time series data, and further substantiated the proposed storage framework on a proof-of-concept testbed using a cluster of low-cost and credit-card-sized single-board computers. We evaluated the proposed distributed storage framework and proof-of-concept testbed with a comprehensive set of performance measures. Results showed that low-cost hardware and open source technologies could be utilized for large-scale time series data storage.