bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Frenchmen in Cannabis”: A Folklore Motif in Ethnolinguistic Perspective
Authors: Белова О.В. 
Published: September 2024

В статье рассматриваются варианты русских и белорусских исторических преданий о борьбе с воинственными противниками (литовцы, шведы, татары, турки, французы). Среди локальных вариантов данного сюжета, зафиксированных в Смоленской области, встречается неординарное упоминание о том, что завоеватели боялись конопли, и это обеспечивало местным жителям возможность укрытия и спасения в зарослях этого растения. Анализ данного фольклорного мотива в этнолингвистическом ракурсе (стереотипный образ этнического «чужака» как возможной ипостаси демонического персонажа; представления о конопле как растении-обереге; диалектная лексика, связанная с аграрной обрядностью и магическими апотропейными ритуалами) позволяет наметить возможные пути становления мотива, его обусловленность локальной системой народных верований и подкрепленность диалектной лексикой и фразеологией (паремиологией). Основной массив фольклорных, языковых и этнографических данных, послуживших базой для исследования, содержится в архивных материалах начала XX в. и полевых записях конца XX в. В статье также представлены результаты текстологического анализа ряда книжных источников, содержащих сведения о фольклорном «тексте конопли», и показано, как в ходе заимствования информации из одного источника в другой и ее интерпретации могут создаваться мифологемы, относящиеся к символам языка культуры.
This article examines variants of Russian and Belarusian historical legends about the struggle against military opponents including Lithuanians, Swedes, Tatars, Turks, and Frenchmen. In one story recorded in the Smolensk region, there is the surprising statement that the invaders were afraid of cannabis, and that this provided residents with the opportunity to escape from them by hiding among these plants. This article analyzes this folklore motif from an ethnolinguistic perspective. It considers the stereotypical image of an ethnic “alien” as a demonic character; ideas about cannabis as a talismanic plant; and the dialect associated with agrarian rituals and magical apotropaic rituals. This suggests possible ways the motif originated, as well as how it was conditioned by the local system of folk beliefs and reinforced by dialect and phraseology (paremiology). The main body of folklore, linguistic and ethnographic data which served as the basis for the study consists of archival materials from the early twentieth century and field records of the late twentieth century. The article also presents textual analysis of several literary sources that contain information about the folkloric “cannabis text,” and shows how, during the process of borrowing and interpretation, mythologems related to a culture’s linguistic symbols may be generated.
EFFECT OF CAPITAL MARKET ON THE ECONOMIC DEVELOPMENT OF EMERGING ECONOMIES; THE NIGERIA EXPERIENCE
Authors: Njoku Charles Odinakachi , Ugwu Kelechi Enyinna , Nwaimo Chilaka Emmanuel , Kekeocha Mary Ezinne , Nwoko Nnenna Mercy , Onyechere Patricia Onyinyechi , Chukwu Oluchi Ebere , Obieche Nkechi Precious 
Published: September 2024

Purpose: This study examined the effect of Nigeria's capital market on the economic development the country. The aim of this study is to determine how much the capital market has contributed to Nigeria's Human Development and Unemployment Reduction in the country. The specific objectives are to determine the effect of: Market Capitalization, All Shares Index, Volume of market Transactions, Value of market Transactions affect both Unemployment rate and Human Development Index.

Methodology: The secondary data for this study came from the World Bank report for the period 1991 to 2022 and the CBN statistical bulletin. The Augmented Dickey-Fuller Unit Root test was conducted to check for the stationarity of the data set, the Johansen co-integration test was used to determine if the relationship in the models exists in either the short run or long run, and the Granger Causality was also conducted. The dependent variables were the Unemployment Rate and the Human Development Index, whereas the independent variables were Market Capitalization, All Shares Index, Transaction Volume, and Transaction Value.

Findings and Conclusion: Market capitalization and the All-Shares Index are significantly correlated with the Human Development Index, although there is no correlation between the Human Development Index and Transaction Volume or Value, according to a review of the regression data. In the second model, the correlations between market capitalization, the All Shares Index, the quantity and value of transactions, and the unemployment rate are not statistically significant. The study's conclusions indicate that while the capital market has a small effect on unemployment, it has a large impact on the Human Development Index. Therefore, in order to eliminate fraud and other unethical actions that breach investor trust, we implore the regulatory authorities to take regulatory measures that tend to improve and maintain the market's Market Capitalization and All Share Index.

Originality: This study contributes to the existing literature by examining how capital market affects economic development in Nigeria. This research has also successfully developed a model that could be used to predict the effect of Capital Market on both Human Development Index and Unemployment Reduction in Nigeria.
PARENTING MANAGEMENT TO PREVENT TOXIC PARENTS
Authors: El-Faradis Fayruzah , Amuzaqiah Anik 
Published: September 2024

Abstract this research described the implementation of parenting that has big role in children improvement. The wrong parenting style could made toxic parenting. Toxic parenting will influence children improvement such as their emotional- less self-confidence, anxiety, etc that impacts the children in their early childhood or their future. This research aim to describe how was the toxic parenting and what are causes and effects of toxic parenting at Ketapang. This research used qualitative, case studies. The sample used simple random sampling and used interview, observation. Data analyzed by triangulation. The result shows that many parents hope the best for their children but delivered in wrong way, in this case they compared their children to others, also disrespect their children and and less of reward from parents of children as their abilities and achievement. So the effect of toxic parents make the children have not enough self-esteem, less confidence, inferior to reach their self-objectives.
Balance del contenido vaginal para detección de patologías asociadas en mujeres en edad fértil
Authors: Gómez Capará L. G. , Goicoechea P. N. , Leyes Pedrozo E. A. , Martemucci C. N. 
Published: September 2024

La microbiota vaginal, compuesta principalmente por Lactobacillus spp., desempeña un papel crucial en la salud genital femenina. La disrupción de este equilibrio puede llevar a diversas patologías, como vaginosis bacteriana (VB) y vaginitis microbiana inespecífica (VMI). Este trabajo se llevó a cabo en colaboración con el Instituto de Formación Docente "José Manuel Estrada" y la Facultad de Bioquímica de la UNNE, involucrando a estudiantes en la recolección y análisis de muestras vaginales. El método BACOVA permitió clasificar las muestras en cinco Estados Vaginales Básicos (EVBs), proporcionando un diagnóstico diferencial preciso de las disfunciones vaginales. De las 14 muestras analizadas, el 86% presentó algún grado de disfunción vaginal, destacando la prevalencia de la microbiota normal con reacción inflamatoria (EVB II). Además, se identificaron casos de infección por levaduras, predominando Candida albicans, y micoplasmas urogenitales, especialmente en estados avanzados de disfunción vaginal. Los resultados subrayan la eficacia del método BACOVA en la identificación temprana de patologías vaginales, su aplicabilidad en contextos de atención primaria y su potencial para optimizar la salud ginecológica y reproductiva. Este proyecto no solo aportó datos valiosos para la salud pública, sino que también fomentó la integración de la docencia con el trabajo comunitario, reforzando la formación práctica y el compromiso social de los estudiantes de Bioquímica.
Genome-Wide Mendelian Randomization Identifies Ferroptosis-Related Drug Targets for Alzheimer’s Disease
Authors: Wang Ying , Song Xinhua , Wang Rui , Xu Xinzi , Du Yaming , Chen Guohua , Mei Junhua 
Published: September 2024

Background: Alzheimer’s disease (AD) currently lacks effective disease-modifying treatments. Recent research suggests that ferroptosis could be a potential therapeutic target. Mendelian randomization (MR) is a widely used method for identifying novel therapeutic targets. Objective: Employ genetic information to evaluate the causal impact of ferroptosis-related genes on the risk of AD. Methods: 564 ferroptosis-related genes were obtained from FerrDb. We derived genetic instrumental variables for these genes using four brain quantitative trait loci (QTL) and two blood QTL datasets. Summary-data-based Mendelian randomization (SMR) and two-sample MR methods were applied to estimate the causal effects of ferroptosis-related genes on AD. Using extern transcriptomic datasets and triple-transgenic mouse model of AD (3xTg-AD) to further validate the gene targets identified by the MR analysis. Results: We identified 17 potential AD risk gene targets from GTEx, 13 from PsychENCODE, and 22 from BrainMeta (SMR p < 0.05 and HEIDI test p > 0.05). Six overlapping ferroptosis-related genes associated with AD were identified, which could serve as potential therapeutic targets (PEX10, CDC25A, EGFR, DLD, LIG3, and TRIB3). Additionally, we further pinpointed risk genes or proteins at the blood tissue and pQTL levels. Notably, EGFR demonstrated significant dysregulation in the extern transcriptomic datasets and 3xTg-AD models. Conclusions: This study provides genetic evidence supporting the potential therapeutic benefits of targeting the six druggable genes for AD treatment, especially for EGFR (validated by transcriptome and 3xTg-AD), which could be useful for prioritizing AD drug development in the field of ferroptosis.
Association Between Kidney Disease Index and Decline in Cognitive Function with Mediation by Arterial Stiffness in Asians with Type 2 Diabetes
Authors: Low Serena , Moh Angela , Goh Kiat Sern , Khoo Jonathon , Ang Keven , Liu Allen Yan Lun , Tang Wern Ee , Lim Ziliang , Subramaniam Tavintharan , Sum Chee Fang , Lim Su Chi 
Published: September 2024

Background: Decline in renal function impairs systemic clearance of amyloid-β which characterizes Alzheimer’s disease while albuminuria is associated with blood-brain barrier disruption due to endothelial damage. Arterial stiffness adversely affects the brain with high pulsatile flow damaging cerebral micro-vessels. Objective: To examine association between a novel kidney disease index (KDI), which is a composite index of estimated glomerular filtration (eGFR) and urinary albumin-to-creatinine ratio (uACR), and cognitive function with potential mediation by arterial stiffness. Methods: This was a longitudinal multi-center study of participants with type 2 diabetes (T2D) aged 45 years and above. We assessed cognitive function with Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Pulse wave velocity (PWV), an index of arterial stiffness, was measured using applanation tonometry method. KDI was calculated as geometric mean of 1/eGFR and natural logarithmically-transformed (ln)(ACR*100). Results: There were 1,303 participants with mean age 61.3±8.0 years. LnKDI was associated with lower baseline RBANS total score with adjusted coefficient –2.83 (95% CI –4.30 to –1.35; p < 0.001). 590 participants were followed over up to 8.6 years. LnKDI was associated with lower follow-up RBANS score in total, immediate memory, visuo-spatial/construction and attention domains with corresponding adjusted coefficients –2.35 (95% CI –4.50 to –0.20; p = 0.032), –2.93 (95% CI –5.84 to –0.02; p = 0.049), –3.26 (95% CI –6.25 to –0.27; p = 0.033) and –4.88 (95% CI –7.95 to –1.82; p = 0.002). PWV accounted for 19.5% of association between and follow-up RBANS total score. Conclusions: KDI was associated with lower cognitive function globally, and in immediate memory, visuo-spatial/construction and attention domains. Arterial stiffness mediated the association between KDI and cognitive decline in patients with T2D.
Effectiveness of Second-Line Cabozantinib in Metastatic Clear Cell Renal Cell Carcinoma Patients After First-Line Treatment with Immune Checkpoint Inhibitor-based Combinations
Authors: Narang Arshit , Gebrael Georges , Jo Yeonjung , Thomas Vinay Mathew , Li Haoran , Fortuna Gliceida Galarza , Sayegh Nicolas , Tandar Clara , Tripathi Nishita , Chigarira Beverly , Srivastava Ayana , Hage Chehade Chadi , Nordblad Blake , Maughan Benjamin L. , Agarwal Neeraj , Swami Umang 
Published: September 2024

Background: Cabozantinib, a tyrosine kinase inhibitor (TKI), is a prevalent second-line (2 L) therapy and was approved for use after progression on TKIs. However, the 1 L treatment setting has changed since the approval of cabozantinib monotherapy in salvage therapy settings. Objective: To assess the differential effectiveness of cabozantinib after prior progression on 1 L ipilimumab with nivolumab (IPI + NIVO) compared to programmed death receptor-1 (PD-1) or PD-1 ligand (PD-L1) inhibitors (PD1/L1i) with TKIs. Methods: Utilizing a nationwide electronic health record (EHR)-derived de-identified database, we included patients with metastatic clear cell renal cell carcinoma (mccRCC) who received 1 L treatment with an immune checkpoint inhibitor (ICI)-based combination and 2 L treatment with cabozantinib monotherapy. These patients were categorized based on the type of 1 L ICI-based combination received: IPI + NIVO vs. PD1/L1i with TKI. Real-world time to next therapy (rwTTNT) and real-world overall survival (rwOS) were summarized using Kaplan-Meier curves and compared using Cox-proportional hazard models adjusted for International mRCC Database Consortium (IMDC) risk groups. Results: Among 12,285 patients with metastatic renal cell carcinoma, 237 were eligible and included. Median rwTTNT was 8 months for the IPI + NIVO subgroup and 7.5 months for the PD1/L1i + TKI subgroup (HR 1.05, 95% CI: 0.74–1.49, p = 0.8). Median rwOS was 17 months for IPI + NIVO and 16 months for PD1/L1i + TKI subgroup (HR 0.79, 95% CI: 0.52–1.20, p = 0.3). Conclusions: Cabozantinib remains effective as a 2 L therapy for mccRCC independent of the type of prior 1 L ICI-based combination. Further research is needed to validate these findings and explore the ideal sequencing of therapies.
The Efficacy of Desmopressin and Imipramine in Retaining the Instilled Suspension in the Bladder
Authors: Bitaraf Masoud , Tanourlouee Saman Behboodi , Amini Erfan , Azimzadeh Ashkan , Muhammadnejad Samad , Mohammdi Sara , Majidi Zolbin Masoumeh , Kajbafzadeh Abdol-Mohammad 
Published: September 2024

OBJECTIVE: To assess the efficacy of desmopressin and imipramine in reducing urination frequency, and retaining the instilled suspension in the bladder without maintaining the mouse under anesthesia.

METHOD: Twenty-four mice were divided into four groups: (1) control, (2) four-hour water deprivation, (3) two µg/kg intraperitoneal desmopressin, and (4) two µg/kg intraperitoneal desmopressin plus 30 mg/kg imipramine gavage. Micturition frequency was recorded using voiding spot assay. Animals were catheterized and 50 µl of methylene blue was instilled into the bladder. The mice were then placed on a white paper to recover. Blue voiding was documented.

RESULTS: Urination frequency was significantly lower in the desmopressin group. The water-deprived and desmopressin/imipramine-combination groups did not differ significantly compared to control group. All animals voided methylene blue upon recovery.

CONCLUSION: Desmopressin notably reduced urination frequency. In contrast, water deprivation did not do so. Desmopressin and imipramine failed to cause suspension retention in awake mice.
Pengaturan Hukum Biota Laut Dalam Kawasan Ombo Laut Dalam Perspektif Pluralisme Hukum di Desa Wabula
Authors: Failu Ismail , Salam Safrin 
Published: September 2024

Ombo Laut yang dimiliki oleh Masyarakat Hukum Adat Wabula telah mendapatkan pengakuan dan perlindungan hukum. Penelitian hukum ini menggunakan jenis penelitian hukum socio-legal. Lokasi penelitian ini dilakukan di Desa Wabula, Kecamatan Wabula, Kabupatan Buton. Adapun waktu penelitian adalah tahun 2023. Hasil analisis data akan diolah melalui aplikasi JASP dan hasilnya dihubungkan dengan peraturan perundang-undangan melalui metode penafsiran hukum. Hasil penelitian menunjukan bahwa Pengaturan hukum biota laut dalam kawasan Ombo Laut dalam perspektif pluralisme hukum telah terakomodir di dalam Peraturan Bupati Buton Nomor 13 Tahun 2018 dan Peraturan Desa No. 3 Tahun 2006 tentang Aturan Pelaksanaan Pengelolaan Terumbu Karang Terpadu Desa Wabula Kecamatan Wabula Kabupaten Buton sedangkan sanksi hukum atas pelanggaran pengelolaan biota laut dalam kawasan ombo diatur beberapa ketentuan hukum yakni a) Subjek pelanggar ; b) Penggunaan alat mancing diatur; c) Terdapat variasi penggunaan sanksi mulai dari sanksi perdata berupa denda dan juga sanksi pidana berupa pidana penjara dan yang terakhir adalah sanksi berupa sanksi adat.
Perlindungan Hukum Terhadap Pejabat Notaris Yang Membuat Perjanjian Perkawinan Selama Perkawinan Berlangsung
Authors: Muhtar Achmad , Rato Dominikus , Dwi Anggono Bayu 
Published: September 2024

Pada mulanya proses perkawinan dimulai dari adanya perjanjian perkawinan atau disebut dengan pranikah. terdapat kegelisahan akademis yang mana dapat diinventarisir terkait dengan permasalahan perjanjian perkawinan yakni terdapat konflik norma hal tersebut ditandai dengan adanya putusan Mahkamah Konstitusi pada amar putusannya menegaskan bahwa Pejabat notaris diberi kewenangan untuk mengesahkan perjanjian perkawinan. Sedangkan di dalam Undang-Undang Nomor 2 Tahun 2014 tentang Perubahan atas UU No. 30 Tahun 2004 tentang Jabatan Notaris yang mana pada undang-undang tersebut tidak ada ketentuan yang mengatur tentang kewenangan notaris untuk mengesahkan perjanjian Kawin yang dibuat oleh para Pihak selama masa perkawinan, sehingga Pejabat notaris tidak ada alasan hukum yang kuat sebagai landasan Pembuatan Perjanjian Kawin. Adapun rumusan masalah dalam penelitian ini ialah Pertama, Apa Hakekat Perjanjian Perkawinan menurut Hukum Positif di Indonesia? Kedua, Bagaimana bentuk perlindungan hukum bagi pejabat notaris dalam Perjanjian Perkawinan yang dibuat setelah perkawinan? Ketiga, Bagaimana Perumusan Perjanjian Perkawinan yang dibuat selama masa Perkawinan (postnuptial agreement) dapat memberikan kepastian Hukum? Adapun metode yang digunakan ialah metode yuridis normatif. Adapun hasil dalam penelitian ini ialah perjanjian perkawinan dibuat sebelum dan pada saat perkawinan berlangsung. Selain itu apabila tidak ada perkawinan perjanjian yang dilakukan sebelumnya maka harta asal atau harta yang diperoleh selama perkawinan tidak adanya pemisahan terhadap harta tersebut (harta bersama). Selain itu notaris yang diberikan wewenang apabila dalam membuat perjanjian harus sesuai dengan syarat sahnya perjanjian dan apabila tidak sesuai dengan syarat sahnya perjanjian maka akan dibatalkan oleh hakim. Adanya hal tersebut tentunya dapat memberikan kepastian hukum bagi notaris.
Pelatihan Pengelasan dan Inspeksi kepada Siswa SMAN 3 Sampang sebagai Upaya Penguatan Indeks Pembangunan Manusia (IPM)
Authors: Syarifuddin Arief , Ilmah Aurista M. , Prasetyo Taufan , Aldara Desta Rifky , Abdullah Mohammad 
Published: September 2024

Pulau Madura memiliki potensi alam dan pariwisata yang sangat luar biasa, namun potensi tersebut belum bisa dikelola secara maksimal dikarenakan rendahnya kemampuan Sumber Daya Manusia yang dimiliki untuk mengelolanya. Bukti dari rendahnya kualitas SDM masyarakat pulau Madura ditunjukkan oleh Indeks Pembangunan Manusia (IPM) yang juga sangat rendah. Politeknik Negeri Madura (POLTERA) sebagai institusi pendidikan melalui Jurusan Teknologi Kemaritiman berupaya mengambil peran untuk bisa meningkatkan IPM masyarakat pulau Madura dengan membuat pelatihan pengelasan dan inspeksi. Sasaran dari pelatihan ini adalah siswa SMAN 3 Sampang yang memiliki rekam jejak baik dengan POLTERA. Pelatihan dilaksanakan selama dua hari dengan rincian satu hari untuk pemaparan teori dan satu hari untuk praktik pengelasan dan inspeksi. Hasil pelatihan pengelasan dan inspeksi menunjukkan tren yang positif, terbukti dari peningkatan nilai post test jika dibandingkan dengan pre test. Perbaikan perlu dilakukan untuk kegiatan pelatihan selanjutnya berdasarkan hasil kuisioner khususnya terkait materi pelatihan dan konsumsi. Pelatihan sejenis ini bisa dijadikan agenda rutin tahunan untuk meningkatkan ketertarikan siswa SMA dan SMK di Pulau Madura melanjutkan studi hingga perguruan tinggi, sehingga berdampak kepada kenaikan IPM.
Enhancing speech perception in challenging acoustic scenarios for cochlear implant users through automatic signal processing
Authors: Buechner Andreas , Bardt Michael , Kliesch Sven , Lenarz Thomas , Brendel Martina 
Published: September 2024

ObjectivesThis clinical study investigated the impact of the Naída M hearing system, a novel cochlear implant sound processor and corresponding hearing aid, featuring automatic scene classification systems which combine directional microphones and noise reduction algorithms, on speech perception in various acoustic scenarios.MethodsSpeech perception was assessed in 20 cochlear implant (CI) recipients, comprising both bilaterally implanted and bimodal listeners. Participants underwent the adaptive matrix sentence test in both quiet and noisy environments. The automatic scene classifier (ASC, AutoSense OS 3.0) involving different microphone settings was evaluated against the omni-directional microphone on the Naída M hearing system. The predecessor hearing system Naída Q served as reference. Furthermore, the automatic focus steering feature (FSF, Speech in 360°) of the Naída M hearing system was compared to the manual FSF of the Naída Q hearing system in a multi-loudspeaker setup.ResultsWhile both sound processor models yielded comparable outcomes with the omni-directional microphone, the automatic programs demonstrated an enhancement in speech perception: up to 5 dB or 40% in noise for the latest sound processor relative to its predecessor. Subjective feedback further underscored the positive experience with the newer generation system in everyday listening scenarios.ConclusionThe Naída M hearing system features advanced classification systems combined with superior processing capabilities, significantly enhancing speech perception in noisy environments compared to its predecessor, the Naída Q hearing system.