bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADNOC’s Journey to Turn Social Risk Management into Action
Authors: Luca C. W. F. , van Cranenburgh K. C. , Aguirre J. D. Correa 
Published: September 2024

Abstract
In 2020, ADNOC started introducing social risk management (SRM) in project delivery and operations to prepare for the increasingly complex social performance demands of local and international stakeholders. Effective implementation requires early assessment of social impacts and proactive engagement of stakeholders, which can only be achieved if all technical and non-technical (outward-looking) disciplines work seamlessly together. This paper describes an integrated and multi-disciplinary approach to achieve this, aligned with international standards, yet adapted to local customs.
ADNOC’s HSE Management System was chosen as the backbone of the program to which a dedicated SRM policy and standard were added. This SRM standard includes requirements, processes, reporting templates and tools to perform social impact assessments and engage external stakeholders. Key topics of the standard were aligned with international standards on social performance and stakeholder engagement, and blended with local culture and customs. A company-wide training program, appointment of SRM specialists, and coaching by specialized consultants were provided to support implementation. An internal organizational structure was designed to ensure internal alignment between the various disciplines, a prerequisite for consistent communication with external stakeholders. Implementation of the foundations of the SRM program was completed over a period of three years with external help. Internal resources are now continuing implementation.
The prerequisite of internal alignment across all layers of ADNOC was and is the most important and challenging part of the program. ADNOC is a conglomerate of many different companies and ventures in which cross-organizational and cross-disciplinary alignment at operational level does not come naturally. Therefore, the program design had to address both the organizational and behavioral aspects of this situation. The speed of implementation could only happen thanks to strong and direct involvement of ADNOC senior management.
Several more years are needed until SRM is fully embedded as a new discipline, adequately resourced and experienced, and until its policy and procedures are implemented as a matter of business-as-usual, not only within ADNOC, but also amongst its partners, suppliers and contractors. In addition, SRM will need to be kept up to date with international developments such as new directives by the European Union that are turning international standards into regulation.
ADNOC’s program is the first and most comprehensive approach to social performance in the Gulf region that successfully blends local customs and international requirements for social performance. A key novelty of the program is the organizational model that enhances internal cooperation and alignment between disciplines and operating companies in ADNOC to ensure consistency of implementation and a single voice to external stakeholders.
PAM Water Salinity Evaluation to Enhance Deep-Water Disposal Strategy in Amin Formation
Authors: AL Isaee Omar , Smirnov Dmitrii 
Published: September 2024

Abstract
Injecting disposal water at Haima Group intervals give us an additional overlaying volume of rocks that helps to control and contain the water injected in the bottom. The main criterion for selecting the Haima group to inject the produced water, is that the in-situ aquifer water salinity meets the legal requirement which is above 35,000 ppm. This work was done to enhance deep-water disposal strategy in Water Bearing Formation.
The pressure data analysis model (PAM) is introduced using the re pre-computation module "Water properties from temperature, pressure and salinity" to estimate formation water density. Formation temperature and pressure values used as an input for the calculation are based on wireline pressure measurements. Different water salinity values are used to find a good match between the calculated water density in the pressure data analysis model (PAM) and water density from pressure gradient and hence water salinity for known water density, temperature and pressure can be estimated.
It is likely that deep invasion occurred in most DWD (Deep Water disposals) wells while drilling. This has significant effect in the resistivity data, which lead to wider range of the calculated mud filtrate salinity. However, results of formation pressure measurements are not affected by mud invasion. Therefore, the pressure data analysis model (PAM) provides reasonable confidence in the formation water salinity in DWD (Deep Water disposals) area. Safe top perforation depth range is easily determined considering the uncertainties. Uncertainty for the water salinity estimate is mainly depending on the uncertainty for the formation pressure gradient. Pressure gradient uncertainty is related to the water density & salinity change with the depth. the pressure data analysis model (PAM) helps to meet the legal requirement for water disposal strategy (above 35,000 ppm) in in-situ aquifers. Pickett plot analysis and MDT water sampling are not recommended in the DWD (Deep Water disposals) area due to expected deep invasion profile.
The novelty of the pressure data analysis model (PAM) for evaluating the formation water salinity is that this method provides reasonable confidence of the water salinity across the entire interval without the need to have BH fluid sampling (much expensive). This helps to have a better deployment in executing the future DWD (Deep Water disposals) in the area and optimizing the injecting interval.
The Future of Field Operations: Unmanned Aerial Systems Innovating Safety and Efficiency in Khurais
Authors: Alhamraa Abdulla Mashan , Shahrani A. O. , Dossary B. N. , Obayaih S. N. 
Published: September 2024

Abstract
This paper explores the transformative impact of unmanned aerial systems (UAS) on operational efficiency, safety, and emergency response within the Khurais oil fields. By integrating sophisticated drone technology, significant improvements have been achieved in routine inspections, leak detection, and emergency scenarios. The study highlights the pivotal role of drones in enhancing operational excellence, providing a model for innovation in the oil and gas industry.
Managing Societal Aspects of Exploration & Production Operations in Sensitive Area: Case in Mahakam Block
Authors: _ Suripno , Arini Frisca , Rahmaningrum Riana , Yuli Ahmad 
Published: September 2024

Abstract
Stakeholders are one of the important actors in operations in the Block Mahakam Working Area. PT Pertamina Hulu Mahakam (PHM) has conducted Identification, Mapping and Assessment of stakeholders to determine key stakeholders. PHM has challenges in its operational activities to continue to find new sources of oil and gas reserves through exploration and exploitation to achieve production targets in the mature block Mahakam in meeting Indonesia's energy needs. The drilling and production process can have an impact on communities around the operating area that intersect directly which makes the location/ area can be a sensitive area. Geographically unique, which is a forestry area that administratively records 3 villages in the Mahakam Delta, namely Sepatin Village, Muara Pantuan Village and Tani Baru Village, are included in the sensitive area with a total population of 13,025 people (in 2019). Low income and education levels are a concern for the company. In addition, basic needs such as clean water, electricity, and communication networks are difficult to access. Problems that occur around the operation area can create social jealousy for the local community. This is a special concern to measure the risks that impact the company to determine the action plan.
Digital Lockout/Tagout Tracking and Control System
Authors: Khawi H. A. , Asmary A. M. 
Published: September 2024

Abstract
The effectiveness of the Lockout/Tagout (LOTO) system is vital to achieving optimum workplace safety in the oil and gas industry. As a traditional method, LOTO can be considered as much a tool as the training provided to the industrial workforce for awareness of the system. It is necessary but not adequate alone to ensure a foolproof LOTO system. This paper examines the conversion of the LOTO system into a computerized configuration, which will consequently shoot it another notch with an additional layer of safeguarding protection toward a better overall safety measurement. The tracking of every lock used or removed on any piece of equipment within the plant is therefore done meticulously by this digital LOTO system. Besides, it continuously monitors for any leak in the system and reports the occurrence. In this regard, safety was being observed from all angles.
The electronic interface is developed to be user-friendly. For instance, isolation equipment and details of the LOTO can be documented and replace age-old manual paperwork that was in use. This changeover to an electronic system makes the whole exercise easy and, in the process, makes the entire exercise efficient and minimizes the chances of human error taking place. Among the benefits of system digitalization is that the LOTO system integrates with the Power BI dashboard. Hence, the safety compliance coordinators and company management are in a position to monitor the LOTO system from far places in real time. The real-time data availed by the dashboard makes decisions timely and assures that issues are dealt with on time to sustain a high level of safety compliance. Digital lockout/tag-out systems also benefit operational policies. It reduces downtime during quarterly assessments since the digital records are more accessible and easily audited than paper logs. The system also minimizes errors that can be made in manual entry and record-keeping. This, therefore, heightens safety in workplaces.
A digital system improves efficiency and access in LOTO and ensures a safer working environment for the oil and gas industry. By adopting digital solutions, companies can be assured of a more reliable and robust LOTO system, thus ensuring more protection for their workforce and assets.
Systemic and local immune responses to glioblastoma surgery help tailoring combinatory regimens
Authors: Bastiancich Chiara , Snacel-Fazy Emmanuel , Fernandez Samantha , Robert Stephane , Stacchini Roberta , Plantureux Lea , Boissonneau Sebastien , Testud Benoit , Guillet Benjamin , Debarbieux Franck , Luche Hervé , Figarella-Branger Dominique , Estève Marie-Anne , Tabouret Emeline , Tchoghandjian Aurélie 
Published: September 2024

Abstract

Glioblastoma (GBM), an incurable primary brain tumor, typically requires surgical intervention followed by chemoradiation; however, recurrences remain fatal. Our previous work demonstrated that a nanomedicine hydrogel (GemC12-LNC) delays recurrence when administered post-surgery. However, tumor debulking also triggers time-dependent immune reactions that promote recurrence at the resection cavity borders. We hypothesized that combining the hydrogel with an immunomodulatory drug could enhance therapeutic outcomes. A thorough characterization of the post-surgical microenvironment (SMe) is crucial to guide combinatorial approaches.
In this study, we performed cellular resolution imaging and flow cytometry to characterize the SMe in a syngeneic mouse model of tumor resection. Owing to our dynamic approach, we observed transient opening of the blood-brain barrier (BBB) during the first week after surgery. BBB permeability post-surgery was also confirmed in GBM patients. In our murine model, we also observed changes in immune cell morphology and spatial location post-surgery over time in resected animals as well as the accumulation of reactive microglia and anti-inflammatory macrophages in recurrences compared to unresected tumors. Therefore we investigated whether starting a systemic treatment with the SMAC mimetic small molecule (GDC-0152) directly after surgery would be beneficial for enhancing microglial anti-tumoral activity and decreasing the number of anti-inflammatory macrophages around the GemC12-LNC hydrogel-loaded tumor cavity. The efficacy of this combination therapeutic approach was confirmed by survival analysis and correlated with reversal of the immune profile as well as delayed tumor recurrence.
This comprehensive study identified critical time frames and immune cellular targets within the SMe, aiding in the rational design of combination therapies to delay recurrence onset. Our findings suggest that post-surgical systemic injection of GDC-0152 in combination with GemC12-LNC local treatment is a promising and innovative approach for managing GBM recurrence, with potential for future translation to human patient.
NUCKS1 promotes invasion and metastasis of colorectal cancer by stabilizing HDAC2 and activating AKT
Authors: Song Yang , Zhu Liaoliao , Zhao ting , Su Haichuan , Li Junqiang , Shen jing , Zhang liang , Chen jun 
Published: September 2024

Abstract

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) functions as an oncogene in colorectal cancer (CRC), promotes the progression of CRC, and is associated with poor prognosis in patients. Studies have found that NUCKS1 promotes tumor cell metastasis, yet its role in CRC invasion and metastasis remains unclear. To investigate this, transwell migration and invasion assay, wound healing assay, and immunofluorescence assay were performed in vitro. Additionally, label-free protein quantification, coimmunoprecipitation (Co-IP), q-PCR, and Western blotting were utilized to analyze NUCKS1's molecular mechanisms in CRC. In vivo, CRC cells were injected into the tail vein to examine NUCKS1's impact on lung and liver metastasis in mice, with hematoxylin-eosin (HE) staining used to evaluate metastatic lesion sizes. Results indicated higher NUCKS1 expression in metastatic CRC compared to non-metastatic samples. Knockdown of NUCKS1 in vitro inhibited CRC invasion and metastasis. Moreover, NUCKS1 was initially found to upregulate HDAC2 expression by inhibiting the lysosomal pathway, activating AKT, and thus promoting CRC invasion and metastasis. In vivo, overexpression of NUCKS1-induced lung and liver metastasis was suppressed by HDAC2 knockdown or intraperitoneal administration of the HDAC2 inhibitor Santacruzamate A. These findings suggest that NUCKS1 contributes to CRC invasion and metastasis by stabilizing HDAC2 and activating AKT, highlighting NUCKS1 and HDAC2 as potential therapeutic targets for CRC.
Strategies for Implementing GlobalConsent to Prevent Sexual Violence in University Men (SCALE): Study Protocol for a National Implementation Trial
Authors: Yount Kathryn M , Whitaker Daniel , Fang Xiangming , Trang Quach Thu , Macaulay Meghan , Hung Minh Tran 
Published: September 2024

Abstract

Background
Globally, women 15–24 years are at heightened risk of sexual violence victimization, a risk factor for adverse mental, physical, and behavioral health outcomes. Sexual violence is common at universities and most often perpetrated by men, yet few evidence-based prevention strategies targeting men have been tested in low- and middle-income countries. GlobalConsent is a six-module, web-based educational program adapted from an efficacious U.S.-based program. Nine months post-treatment in a randomized trial in Vietnam, GlobalConsent reduced men’s sexually violent behavior (Odds Ratio [OR] = 0.71, 95%CI 0.50-1.00) and increased prosocial intervening behavior (OR = 1.51, 1.00-2.28) relative to an attention-control. Evidence regarding optimal implementation strategies for scale up is needed.
Methods
We will randomize six medical universities in North, Central, and South Vietnam to deliver GlobalConsent using two different packages of implementation strategies that vary in intensity. Higher-intensity strategies will include greater 1) pre- and post-implementation engagement with university leaders and faculty, and 2) greater pre-implementation outreach, follow-up, and incentives for students to promote engagement and completion of GlobalConsent. Higher intensity universities will receive additional training and support for their added activities. We will compare implementation drivers and outcomes, intervention effectiveness, and cost-effectiveness across the two implementation bundles. Our mixed-methods comparative interrupted time-series design includes 1) qualitative interviews and quantitative surveys with university leaders and implementation teams to assess implementation barriers and facilitators; 2) repeated surveys with leaders and faculty, implementation teams, and male students to assess multilevel implementation drivers and outcomes, 3) repeated surveys with male students to assess behavioral outcomes (sexual violence and intervening behavior) and mediating variables (knowledge, attitudes, affect, and capacities), and 4) time diaries and cost tracking to assess cost effectiveness of the two implementation-strategies bundles.
Discussion
This project is the first to assess packages of implementation strategies to deliver an efficacious web-based sexual-violence-prevention program for undergraduate men across all regions of Vietnam and synergizes with a violence-prevention training initiative (D43TW012188). This approach will produce rigorous evidence about how to disseminate GlobalConsent nationally, which holds promise to reduce gender-based health inequities linked to sexual violence as GlobalConsent is brought to scale.
Trial registration
NCT06443541. Retrospectively registered with clinicaltrials.gov.
Association of single and combined effects of blood heavy metals with cognitive function in older adults of the United States: A cross-sectional study
Authors: Wang Na , Guo Liang , Shi Menglian , Wang Long , Zhou Ying , Liu Huanbing , Xu Xin qun 
Published: September 2024

Abstract

Background
Heavy metal exposure has been associated with various diseases. The purpose of this study was to determine the single and combined effects between blood heavy metals and cognitive function in older adults.
Methods
This observational study utilizes data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014 and involved 1460 participants aged ≥ 60 years. The concentrations of blood lead (Pb), cadmium (Cd), mercury (Hg), selenium (Se), and manganese (Mn) were measured using inductively coupled plasma mass spectrometry (ICP-MS). Cognitive function was assessed using the immediate Recall test (IRT), delayed recall test (DRT), animal fluency test (AFT), and digit symbol substitution test (DSST). Linear regression, restricted cubic spline (RCS), and subgroup analyses were used to assess the relationship between blood heavy metal concentrations and cognitive function.
Results
Multiple linear regression analysis showed a negative correlation between Cd concentrations and comprehensive cognitive scores (β=-2.698, 95% CI: -4.842, -0.554). Blood Se levels were positively correlated with comprehensive cognitive scores (β = 0.049, 95% CI: 0.022, 0.076) and all four cognitive domains. The RCS showed that the dose-response association between Cd and comprehensive cognitive scores appeared to be linear (P-nonlinear = 0.566), while Se exhibited a parabolic shape tilted to the left relationship with comprehensive cognitive scores (P-nonlinear = 0.013).
Conclusions
A high concentration of Cd is strongly associated with cognitive decline. However, the protective effect of Se on cognitive function plateaus after reaching a certain concentration. These findings may have significance for the development of interventions aimed at alleviating cognitive impairment.
GINNA, a 33 resting-state networks atlas with meta-analytic decoding-based cognitive characterization
Authors: Gillig Achille , Cremona Sandrine , Zago Laure , Mellet Emmanuel , de Schotten Michel Thiebaut , Joliot Marc , Jobard Gaël 
Published: September 2024

Abstract

Since resting-state networks were first observed using magnetic resonance imaging (MRI), their cognitive relevance has been widely suggested. These networks have often been labeled based on their visual resemblance to task activation networks, suggesting possible functional equivalence. However, to date, the empirical cognitive characterization of these networks has been limited. The present study introduces the Groupe d’Imagerie Neurofonctionnelle Network Atlas, a comprehensive brain atlas featuring 33 resting-state networks. Based on the resting-state data of 1812 participants, the atlas was developed by classifying independent components extracted individually, ensuring that the GINNA networks are consistently detected across subjects. We further explored the cognitive relevance of each GINNA network using meta-analytic decoding and generative null hypothesis testing, linking each network with cognitive terms derived from Neurosynth meta-analytic maps. Six independent authors then assigned one or two cognitive processes to each network based on significant terms. The GINNA atlas showcases a diverse range of topological profiles, including cortical, subcortical, and cerebellar gray matter, reflecting a broad spectrum of the known human cognitive repertoire. The processes associated with each network are named according to the standard Cognitive Atlas ontology, informed by two decades of task-related functional magnetic resonance imaging, thus providing opportunities for empirical validation.
The SUPERMAN orthologous Genes PaSUP1/2/3 of Platanus × acerifolia Have Functional Differentiation in Transgenic Arabidopsis
Authors: Zhou Zheng , Zhang Jiaqi , Bao Manzhu 
Published: September 2024

Abstract

The gene SUP (SUPERMAN) encodes a transcription factor that plays an important role in floral organ development in Arabidopsis thaliana. There are three SUP orthologous genes PaSUP1/2/3 in London plane (Platanus × acerifolia) that contain two conserved domains involving C2H2-type zinc finger motif and EAR-like repression motif. The spatial expression pattern of PaSUP1 indicated its sex-specific expression at female inflorescences, while the temporal expression pattern in flower-bud reflected its role in the differentiation of unisexual flowers. Nevertheless, other two orthologous genes PaSUP2/3 had inactive expression patterns around the year. The subcellular localizations of PaSUP1/2/3 implied that they were more than nuclear-localized. Both 35S::PaSUP1 transgenic Arabidopsis and tobacco showed developmental defects in floral organs similar to the ectopic expression of SUP, whereas 35S::PaSUP2/3 transgenic Arabidopsis showed only abnormal leaf phenotype. In 35S::PaSUP1 transgenic Arabidopsis and tobacco, floral organs were smaller than wild-type and the outer three whorls had been more strongly suppressed compared to the fourth whorl. The epidermal cells on floral organs of 35S::PaSUP1 transgenic Arabidopsis were smaller than wild-type through scanning electron microscopy observation. Transcriptome analysis at inflorescences of 35S::PaSUP1 transgenic Arabidopsis indicated that anther and pollen developmental related genes were significantly downregulated. Meanwhile, the yeast two-hybrid assay and BiFC analysis demonstrated interactions between PaSUP1 and TFL2, which may lead to the downregulation of auxin-related genes YUC1/4 in inflorescences of transgenic Arabidopsis. Moreover, transgenic Arabidopsis with pPI::PaSUP1 showed normal vegetative growth without fruits. In the future, PaSUP1 transgenic modification in London plane may help to cultivate sterile germplasm, which can solve problems of pollen allergy and seed hairs in practical applications.