bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Quality Improvement Interventions at Reducing Inappropriate Cardiac Imaging
Authors: Chaudhuri Dipayan , Montgomery Alison , Gulenchyn Karen , Mitchell Morgan , Joseph Philip 
Published: January 2016

Background—
Between 5% and 25% of cardiac imaging tests are performed for inappropriate indications. Studies have examined the impact of appropriate use criteria–based quality improvement initiatives on inappropriate testing, but they have not been systematically evaluated.

Methods and Results—

We performed a systematic review of studies evaluating quality improvement initiatives aimed at reducing inappropriate cardiac imaging. The primary outcome was the proportion of inappropriate tests based on appropriate use criteria. Studies were analyzed using a random effects meta-analysis model, and heterogeneity was examined using subgroup analyses. We identified 6 observational studies and 1 randomized control trial. Most interventions (n=6) had a formal education component, and 5 included a mechanism for physician audit and feedback. Although these interventions were associated with lower odds of inappropriate testing (odds ratio, 0.44 [95% confidence interval, 0.32–0.61];
P
<0.001), significant heterogeneity was observed (
I
2
=70%), which was best explained by the utilization of physician audit and feedback. Interventions that employed physician audit and feedback were associated with significantly lower odds of inappropriate testing (odds ratio, 0.36 [95% confidence interval, 0.31–0.41];
P
<0.001;
I
2
=0%), whereas those that did not had no effect (odds ratio, 0.89 [95% confidence interval, 0.61–1.29];
P
=0.51;
I
2
=0%;
P
value for difference <0.001). All studies had potential sources of bias that could have affected the observed estimates.

Conclusions—
Interventions using physician audit and feedback are associated with lower odds of inappropriate cardiac testing. Further research is needed to evaluate a greater diversity of intervention types, with improved study designs.
Analysis of changes in expression of IL-4/IL-13/STAT6 pathway and correlation with the selected clinical parameters in patients with atopic asthma
Authors: Antczak Adam , Domańska-Senderowska Daria , Górski Paweł , Pastuszak-Lewandoska Dorota , Nielepkowicz-Goździńska Agnieszka , Szewczyk Karolina , Kurmanowska Zofia , Kiszałkiewicz Justyna , Brzeziańska- Lasota Ewa 
Published: January 2016

Introduction: Asthma is associated with activation of interleukin-4 (IL-4)/interleukin-13 (IL-13)/signal transducer and activator of transcription factor-6(STAT6) inflammatory response via overexpression of all pathway components: IL-4, IL-13, and STAT6. Objectives: To evaluate the association of IL-4, IL-13, and STAT6 expression and immunoexpression with atopic asthma development. Patients and methods: Fifty patients with atopic asthma and 20 healthy controls were enrolled into the study. Relative gene expression was analyzed by qPCR method. Immunoexpression was assessed by ELISA method. Results: The expression levels of IL-4, IL-13, and STAT6 were higher in patients compared to the controls, but a statistically significant difference was observed only for IL-13 ( P = 0.03). In immunoexpression analysis, a statistically significant difference between patients and controls was found for IgE ( P = 0.03). Significant positive correlations in the patient group were found between IL-13 gene expression and total level of serum IgE (rho = 0.230, P = 0.033), STAT6 gene/STAT6 protein and total level of serum IgE ( STAT6: rho = 0.077, P = 0.038; STAT6: rho = 0.049, P = 0.042), IL-4, and STAT6 expression (rho = 0.098, P = 0.048). Any significant correlations were found between expression/immunoexpression levels of the studied genes and clinical classification, clinical features, or lung function parameters. Conclusions: Our data support the role of Th2 cytokines (IL-4, IL-13) and STAT6 in Th1/Th2 imbalance and highlight the etiological relationship between IL-4/IL-13/STAT6 signaling and atopy and asthma.
Psychiatric care at a national mental institution during the Spanish Civil War (1936–39): Santa Isabel de Leganés
Authors: Vázquez de la Torre Paloma , Villasante Olga 
Published: January 2016

The scanty research available regarding the health of the mentally ill during the Spanish Civil War is largely due to the loss of most documents, and to the difficulty in accessing the existing archives for decades. Up to the present time, historiography has described overcrowded facilities for the mentally disturbed and the fact that old buildings such as convents and spas were turned into establishments for treating patients with mental problems during the Civil War. However, research reviewing the institutional life and conditions of psychiatric patients during this war is still rather scarce. The aim of our article is to discuss the characteristics of the patients at Santa Isabel National Mental Asylum between 1936 and 1939, as well as the functioning of this institution located in Leganés, a city to the south of Madrid (Spain). The method for this study includes a review of the medical records, statistical registers and other documents kept in the institution’s Historical Archive. In addition, using documents from other Spanish archives, as well as information obtained from contemporary and secondary sources, we attempt to describe similarities to and differences from other mental institutions.
Nebulizer Characteristics for Certification Tests of Biosafety Cabinets with Bacteria and Simulants
Authors: First Melvin W. , Macher Janet , Gussman Robert , Stuart David , Webb Terence 
Published: January 2016

NSF International Standard 49–1992, that covers certification of biological safety cabinets, makes “special note” that a “stainless steel 6-jet Collison refluxing nebulizer will deliver the [required] bacterial spore aerosol” when certain stated conditions are met and “need not be retested for performance before use” (Appendix-C, page C1) (1). The basis on which this nebulizer was vetted was presented at the XXV Biological Safety Conference (Boston, MA, 1984) but never published in the open literature. In view of the importance of this device for the procedures used to certify the performance of biological safety cabinets, the authors are of the opinion that the test protocols and test data on which the selection was based should be made a matter of record. Collison nozzle studies were conducted to determine (a) whether all 6 Collison nozzles manufactured by BGI give the same spore output when operated at 140 kPa (20 psig) with an equal number spore suspension in the flask (b) whether spore delivery by the 6-jet Collison nozzle equals or exceeds the minimum number specified by NSF 49 when charged with the recommended spore suspension (c) whether performance of Collison nozzles with a bacterial spore aerolsol can be predicted accurately with a monodisperse 1.1 μm polystyrene latex spherical simulant, and (d) the optimum nebulizer flask geometry.
Permitting, the Public and the Future of Animal Biosafety Facilities
Authors: Quimby Fred W. 
Published: January 2016

Biocontainment facilities for animals are complex structures which must comply with numerous, sometimes conflicting, federal, state and local regulations. Agencies responsible for funding the construction of or permitting of such facilities must address the environmental impacts of the operation including the treatment and disposal of regulated medical waste. Our experience illustrates the complex nature of the biocontainment facility permitting process. Furthermore, these experiences have taught us to seek public input early in the planning process and incorporate the public's concerns during the environmental quality review process. Finally, the recent decision in New York to regulate ABSL-3 facilities as regulated medical waste treatment facilities has added significant new requirements and resulted in a cost escalation that threatens the entire project.
Open-field study comparing an essential oil-based shampoo with miconazole/chlorhexidine for haircoat disinfection in cats with spontaneous microsporiasis
Authors: Nardoni Simona , Costanzo Angela Grazia , Mugnaini Linda , Pisseri Francesca , Rocchigiani Guido , Papini Roberto , Mancianti Francesca 
Published: January 2016

Objectives The goal of the present study was to compare the antifungal efficacy of an essential oil (EO) shampoo proven to be effective against Microsporum canis with miconazole/chlorhexidine for topical haircoat disinfection in cats treated concurrently with oral itraconazole. Methods Cats received treatment with oral itraconazole (Itrafungol) at a dose of 5 mg/kg/day pulse administration for 1 week, every 2 weeks for at least 6 weeks and were washed twice a week with a neutral shampoo with added EOs of Thymus serpyllum (2%), Origanum vulgare and Rosmarinus officinalis (5% each) for the period of systemic treatment. This protocol was compared with a conventional treatment (oral itraconazole + 2% miconazole/2% chlorhexidine shampoo). Results The treatment was well tolerated and adverse effects were not recorded. All cats were clinically negative at week 11. With respect to animals with extensive lesions, the speed of resolution was higher in cats with focal lesions. The animals showing diffuse lesions required more than a course of treatment to achieve a mycological cure. There was no significant difference between the number of weeks to obtain mycological cure for cats treated with EOs and animals treated conventionally. Conclusions and relevance The treatment appeared to be effective and well appreciated by the owners. The use of shampoo with the added EOs of T serpyllum, O vulgare and R officinalis would seem an interesting, natural alternative to conventional topical treatment.
OPTIMA: sensitive and accurate whole-genome alignment of error-prone genomic maps by combinatorial indexing and technology-agnostic statistical analysis
Authors: Verzotto Davide , Teo Audrey S M , Hillmer Axel M , Nagarajan Niranjan 
Published: January 2016

Abstract

Background
Resolution of complex repeat structures and rearrangements in the assembly and analysis of large eukaryotic genomes is often aided by a combination of high-throughput sequencing and genome-mapping technologies (for example, optical restriction mapping). In particular, mapping technologies can generate sparse maps of large DNA fragments (150 kilo base pairs (kbp) to 2 Mbp) and thus provide a unique source of information for disambiguating complex rearrangements in cancer genomes. Despite their utility, combining high-throughput sequencing and mapping technologies has been challenging because of the lack of efficient and sensitive map-alignment algorithms for robustly aligning error-prone maps to sequences.

Results
We introduce a novel seed-and-extend glocal (short for global-local) alignment method, OPTIMA (and a sliding-window extension for overlap alignment, OPTIMA-Overlap), which is the first to create indexes for continuous-valued mapping data while accounting for mapping errors. We also present a novel statistical model, agnostic with respect to technology-dependent error rates, for conservatively evaluating the significance of alignments without relying on expensive permutation-based tests.

Conclusions
We show that OPTIMA and OPTIMA-Overlap outperform other state-of-the-art approaches (1.6–2 times more sensitive) and are more efficient (170–200 %) and precise in their alignments (nearly 99 % precision). These advantages are independent of the quality of the data, suggesting that our indexing approach and statistical evaluation are robust, provide improved sensitivity and guarantee high precision.
Negotiating solidarity with potential donors: a study of the images in fundraising letters by not-for-profit organizations
Authors: Lipovsky Caroline 
Published: January 2016

AbstractLetters mailed by not-for-profit organizations in their fundraising campaigns derive their persuasive appeal from a complex interplay of verbal text, typographic features and images, combined in a visual design by means of layout. Drawing on an analysis of photographs from a corpus of fundraising letters and using the visual grammar developed by Kress and van Leeuwen (2006), this study highlights the significant role played by images in orienting potential donors attitudinally towards the text that follows, thus contributing to the persuasive appeal of fundraising letters. More specifically, the study investigates how photographs might contribute to overcoming futility thinking from potential donors. The study also contributes to a richer account of the persuasive appeal of fundraising letters than is currently available in the fields of linguistics and psychology through an integrated methodology that draws on the fields of multimodal analysis and decision-making research.
The Origin of Relative Stability of Di-µ-oxo M–M Chiral Salen Complexes [M–M = Ti(IV)–Ti(IV), V(IV)–V(IV), Cr(IV)–Cr(IV), and Mn(IV)–Mn(IV)]: A Quantum-Chemical Analysis
Authors: Narayanan Radhika , Velloth Archana , Kurahashi Takuya , Fujii Hiroshi , Hada Masahiko 
Published: January 2016

Abstract
Di-µ-oxo dimetal cores can form dinuclear complexes with definite stereochemistries. Recent studies describing the synthesis and evaluation of titanium(IV) and manganese(IV) di-µ-oxo dimetal chiral salen complexes prompted us to explore the corresponding vanadium(IV) and chromium(IV) complexes. We therefore modeled a series of di-µ-oxo dimetal complexes of titanium(IV), vanadium(IV), chromium(IV), and manganese(IV) with tetradentate salen ligands bearing different degrees of steric bulk. Quantum mechanical calculations were conducted to compare the stabilities and molecular structures of these complexes. The results of natural population analysis gave an insight into the charge distribution characteristics of the di-µ-oxo dimetal cores of these complexes. Our calculations showed that the di-µ-oxo dimetal complexes bearing the least sterically encumbered model ligand 1 preferred the M-helical form over the P-helical one. In the titanium(IV) and chromium(IV) complexes containing a practical chiral salen ligand 2, the P-helical form was found to be more stable than the corresponding M-form. In contrast, the corresponding vanadium(IV) and manganese(IV) complexes preferred to exist in the M-helical form. The degree of distortion of the di-µ-oxo dimetal core and the inter ligand interactions were key factors for determining the stability of these complexes.
Selective and Sensitive Chromogenic Detection of Trivalent Metal Cations in Water
Authors: Lozano-Torres Beatriz , El Sayed Sameh , Costero Ana M , Gil Salvador , Parra Margarita , Martínez-Máñez Ramón , Sancenón Félix 
Published: January 2016

Abstract
An azopyridine derivative for the selective and sensitive chromogenic detection of trivalent metal cations in water is described.
Research of the Interaction Problem Between Universities and Employers (Regional Aspect)
Authors: ��������  , Saburova Marina 
Published: January 2016

This article presents the view of government, business and higher education of the Ulyanovsk region in determining the problems of interaction between
the labor market and the market of educational services of high school. The author of the article presents data obtained by means of a fi eld marketing
research in the Ulyanovsk region. In-depth interviews of the expert group was the basic method of research. An expert assessment of the present relations
between universities and employers as in the country as a whole as in the region was obtained. Besides it, experts vision of prospects of these relations for
the next 3-5 years was determined as well as factors and eff ective ways of improving the interaction between universities and business.
Technological and Supplementary Education in Terms of Standardization
Authors: ������  , Bychkov Anatoliy 
Published: January 2016

The work discloses the possibility of usage of an additional education as a resource to ensure primary school pupils mastering with FGOS requirements
for the course �Technology�.
Personal and metasubject learning outcomes taken as the system forming start of the process of technological education. Personal achievements of the
students acquire qualitative new content according to modern state of the technosphere and society.
The problem of making a connection and content succession between educative &amp; research and project activities of scholars as an important part of
FGOS (2nd generation) for school and contents of creative labour of students in the additional education system is revealed in the work.
Substantiated that the work of teachers is directed to ensure the compatibility and interoperability of general (the course �Technology�) and additional
education.
The Quality of Expertise
Authors: Van Wesep Edward D. 
Published: January 2016

Policy makers and managers often turn to experts when in need of information, but we should expect experts to be systematically biased. This is because the decision to research a question implies a belief that research will be fruitful. If priors about the impact of one’s work are correct on average, then those who choose to research a question are optimistic about the quality of their work. The bias varies predictably with attributes of the question being studied. This fact has implications for a variety of mechanism design applications and yields predictions in accordance with a large literature in psychology. This paper was accepted by Teck-Hua Ho, behavioral economics.
When 3 + 1 > 4: Gift Structure and Reciprocity in the Field
Authors: Gilchrist Duncan S. , Luca Michael , Malhotra Deepak 
Published: January 2016

Do higher wages elicit reciprocity and lead to increased productivity? In a field experiment with 266 employees, we find that paying higher wages, per se, does not have a discernible effect on productivity in a context with no future employment opportunities. However, structuring a portion of the wage as a clear and unexpected gift—by offering an unconditional raise after the employee has accepted the contract—leads to higher productivity for the duration of the job. Gifts are roughly as efficient as hiring more workers. This paper was accepted by Uri Gneezy, behavioral economics.
Multiplicity results for elliptic Kirchhoff-type problems
Authors: Baraket Sami , Molica Bisci Giovanni 
Published: January 2016

Abstract
The aim of this paper is to establish the existence of multiple solutions for a perturbed Kirchhoff-type problem depending on two real parameters. More precisely, we show that an appropriate oscillating behaviour of the nonlinear part, even under small perturbations, ensures the existence of at least three nontrivial weak solutions. Our approach combines variational methods with properties of nonlocal fractional operators.
Quantification of β region IgA paraproteins – should we include immunochemical “heavy/light chain” measurements? Counterpoint
Authors: Paolini Lucia 
Published: January 2016

AbstractSerum protein electrophoresis (SPE), serum immunofixation (s-IFE), free light chain measurement (FLC) and nephelometric measurements of total immunoglobulin in serum (IgTot) are some of the laboratory tests required for the management of plasma cell proliferative disorders. The monoclonal protein is usually visible on SPE as a spike (M-spike) in the γ region and the derived densitogram is used to quantify it relative to serum total protein concentration. IgA M-protein, however, often migrates in the β region on SPE and its quantification can be masked by other serum proteins that migrate in this region. The immunoassay Hevylite™ (heavy/light chain, HLC) seems to solve this problem: it quantifies the involved/uninvolved isotype, calculating the ratio IgAκ/IgAλ, considered indicative of clonal proliferation. However, this test seems redundant in the case of artifacts on SPE such as obvious hemolysis or lipemia, or if the IgA M-spike is clearly visible in the β region. In conclusion whereas the IgA HLC assay does not represent an alternative to SPE and s-IFE in the diagnostic patient workup, it may prove to be an alternative to SPE, s-IFE and total IgA quantification in risk stratification and evaluation of response to therapy in patients affected by MM and other monoclonal plasma proliferative disorders.
Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA)
Authors: van de Donk Niels W.C.J. , Otten Henny G. , El Haddad Omar , Axel Amy , Sasser A. Kate , Croockewit Sandra , Jacobs Joannes F.M. 
Published: January 2016

AbstractDaratumumab is a fully human anti-CD38 IgG1-κ monoclonal antibody (mAb) currently being evaluated in several Phase 2 and 3 clinical studies for the treatment of multiple myeloma (MM). In this clinical case study we demonstrate that daratumumab can be detected as an individual monoclonal band in serum immunofixation electrophoresis (IFE). M-protein follow-up by IFE is part of the International Myeloma Working Group (IMWG) criteria to assess treatment response. Therefore, it is crucial that the daratumumab band is not confused with the endogenous M-protein of the patient during IFE interpretation. Moreover, a significant number of IgG-κ M-proteins co-migrate with daratumumab. Co-migration introduces a bias in the M-protein quantification since pharmacokinetic studies show that daratumumab peak plasma concentrations reach up to 1 g/L. More importantly, co-migration can mask clearance of the M-protein by IFE which is necessary for classification of complete response by IMWG criteria (negative serum IFE). For optimal M-protein monitoring the laboratory specialist needs to be informed when patients receive daratumumab, and it is essential that the laboratory specialist is aware that a slow migrating band in the γ-region in those patients may be derived from the daratumumab. A daratumumab specific IFE reflex assay (DIRA) has been developed and can be utilized to abrogate interference. The here described mAb interference is not limited to daratumumab, and as therapeutic antibodies gain approval and enter into common clinical practice, laboratory specialists will need additional processes to characterize IFE interference and distinguish endogenous M-protein from therapeutic antibodies.
A Fitted Finite-Volume Method Combined with the Lagrangian Derivative for the Weather Option Pricing Model
Authors: Chang Shuhua , Tang Wenguang 
Published: January 2016

Abstract
The purpose of weather option is to allow companies to insure themselves against fluctuations in the weather.
However, the valuation of weather option is complex, since the underlying process has no negotiable price. Under the assumption of mean-self-financing, by hedging with a correlated asset which follows a geometric Brownian motion with a jump diffusion process,
this paper presents a new weather option pricing model on a stochastic underlying temperature following a mean-reverting Brownian motion. Consequently, a two-dimensional partial differential equation is
derived to value the weather option. The numerical method applied in this paper is based on a fitted finite-volume technique combined with the Lagrangian derivative. In addition, the monotonicity, stability, and the convergence of the discrete scheme are also derived. Lastly, some numerical examples are provided to value a series of European HDD-based weather put options, and the effects of some parameters on weather option prices are discussed.