bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mastocytoma and juvenile xanthogranuloma in children
Authors: Potekaev N. N. , Kasikhina E. I. , Ostretsova М. N. , Grebenyuk V. N. , Kochetkov M. A. , Katunina O. R. , Buzina K. I. 
Published: September 2024

The growing number of children with rare diseases such as cutaneous mastocytoma and juvenile xanthogranuloma turning to dermatologists, as well as their clinical similarity, dictate the need for specialists to pay careful attention to these diseases. cutaneous mastocytoma is a clinical form of cutaneous mastocytosis. According to the WHO classification (2022), isolated (one focus) and multiple cutaneous mastocytoma (no more than three foci) are distinguished. juvenile xanthogranuloma belongs to the group of non-Langerhans cell histiocytosis, a broad group of related diseases characterized by the proliferation of histiocytes other than Langerhans cells. We describe a case of an unusual clinical course of solitary juvenile xanthogranuloma in a 3-year-old boy referred to Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology with suspected cutaneous mastocytoma. The size, unusual shape, localization of the lesion and elevated levels of serum tryptase exceeding the age norm (<5 μg/l) determined the atypicality of this case. Dermoscopic examination revealed a central deep yellow coloration of the lesion in the center (the setting sun symptom), a vascular pattern and a clouds symptom. Pathological examination confirmed the diagnosis of juvenile xanthogranuloma. The article also reflects the results of a dynamic observation of a child with an isolated large-sized cutaneous mastocytoma. During the examination, an increase in tryptase levels (>20 μg/l), and AST values, as well as ultrasound signs of hepatomegaly were revealed. Features of the dermoscopic and pathomorphological picture demonstrated patterns characteristic of infiltration and increased activity of mast cells. Cutaneous mastocytoma and juvenile xanthogranuloma are rare and benign skin diseases that usually begin in childhood. Diagnosis of rare diseases often requires complex differential diagnosis. Features of the modern course of cutaneous mastocytoma and juvenile xanthogranuloma are an atypical clinical picture and a high risk of developing extracutaneous symptoms. The presented clinical cases demonstrate the need for interdisciplinary monitoring of patients with these diseases and change the stereotypes of treating them as independent and regressive processes without a trace.
Quality of life of patients with dyshidrotic eczema: a cross-sectional study
Authors: Shachnev A. S. , Zhukova O. V. , Kasikhina E. I. 
Published: September 2024

Introduction. Dyshidrotic eczema (DE) is a type of true eczema, prone to chronic recurrent course, which has a negative impact on the quality of life of patients. In the domestic literature, insufficient attention is paid to the study of the role and nature of the course of the disease on the daily life of patients with DE.Aim. To study the quality of life in patients of DE. Provide a description of a clinical cases of DE and experience with external therapy.Materials and methods. 105 patients with DE aged 18 to 52 years were included in the study, the mean age was 31.3 ± 8.1 years. The quality of life was assessed using the Dermatology Life Quality Index (DLQI). The Dyshidrotic Eczema Area and Severity Index (DASI) was used to clinically assess the severity of DE.Results. All patients suffering from DE noted a negative impact of the skin process on the quality of life. At the same time, the average DLQI score in all patients was 6.99 ± 4.6, which indicates a moderate undesirable effect of DE on the quality of life, without statistically significant differences by gender. The average DASI score was 12.6 ± 8.8, which indicates a predominance of mild DE in the sample. In women, a process of moderate severity was more often diagnosed and the DASI index was 13.2 ± 8.5. The study demonstrated that the female gender is more susceptible to the influence of DE symptoms on the quality of life, regardless of the severity and extent of the skin process, and minimal changes in the skin can have a negative impact on the quality of life. The article presents clinical examples of successful treatment of DE localized on the skin of the hands with an external preparation containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole.Conclusion. DE is a common condition and affects quality of life. Proper diagnosis is essential for effective and efficient treatment. External therapy with the inclusion of a cream (ointment) containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole gives better results and increases satisfaction with the treatment of patients with DE.
Dynamics of the level of interleukin 31 and 33, cortisol and filaggrin in the blood serum of pregnant women with atopic dermatitis during treatment with a combination of an emollient and a topical antipruritic agent
Authors: Orlova E. A. , Kandrashkina Yu. A. , Levashova O. A. , Kostina E. M. , Shtakh A. F. 
Published: September 2024

Introduction. The widespread prevalence of atopic dermatitis and decreased quality of life make the problem urgent and require the search for new treatment methods. In atopic dermatitis, excessive expression of interleukins 31 and 33 in keratinocytes is noted. In patients with atopic dermatitis, there is an increase in serum cortisol and filaggrin levels. In recent years, active development of drugs has been carried out, aimed mainly at the immune component of the pathogenesis of atopic dermatitis. However, clinical trials of these drugs are not conducted on pregnant women. For the treatment of atopic dermatitis during pregnancy, we have proposed a regimen of external therapy, including a topical moisturizer and a topical antipruritic agent.Aim. To evaluate the levels of interleukins 31, 33, cortisol and filaggrin in blood serum before and after treatment of atopic dermatitis with a combination of emollient and topical antipruritic agent.Materials and methods. The examination included 76 pregnant women during an exacerbation of atopic dermatitis. The levels of interleukins 31, 33, cortisol and filaggrin were determined in the blood serum at the first visit and after 4 weeks of using the proposed combination of emollient and topical antipruritic agent using enzyme-linked immunosorbent assay (ELISA).Results. Against the background of the proposed therapy, a statistically significant decrease in the concentration of interleukins 31 was noted from 28.98 to 2.08 pg/ml, filaggrin from 9.72 to 5.26 ng/ml, cortisol from 629.80 to 472.25 pg/ml (p = 0,001). There were no statistically significant fluctuations in interleukins 33 levels (p = 0,124).Conclusion. The combination of external therapy with the use of an emollient and a topical antipruritic agent reduces the production of interleukins 31, cortisol and filaggrin in the blood serum, but the content of interleukins 33 does not change significantly.
Hidradenitis suppurativa: latest insights on the etiology, pathogenesis and features of therapy
Authors: Svechnikova E. V. , Zhufina S. Е. 
Published: September 2024

Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory skin disease characterized by the appearance of painful, recurrent inflammatory nodules and abscesses that are prone to spontaneous opening, leading to the formation of fistulous tracts and scarring. Most often, lesions affect the apocrine glands in areas such as the armpits, groin and anogenital area. The pathogenesis of the disease is due to follicular occlusion, which occurs as a result of a number of biological inflammatory processes, including follicular epithelial hyperplasia and hyperkeratinization. According to data from various countries, the incidence ranges from 0.1% to 4%; women aged 18 to 29 years are more likely to suffer from HS, but the disease can also occur during perimenopause. Skin lesions are often accompanied by pain that can compromise daily activities, the presence of disfiguring skin lesions and foul-smelling purulent discharge negatively impact the personal and professional lives of patients. Acute and chronic pain significantly reduces quality of life and is a risk factor for the development of depression. An interdisciplinary approach plays an important role in the treatment of these patients. For treatment, systemic and local antibacterial drugs are used in various combinations and developed regimens, local anesthetics and antiseptics, non-steroidal anti-inflammatory drugs as symptomatic treatment, systemic and topical (intralesional administration) glucocorticosteroids, retinoids, physiotherapy, laser therapy, and biological drugs. Inhibitors of TNF-alpha, IL-17 act as modern pathogenetic therapy, showing good results in practice. The study of pathogenesis and the use of targeted therapy are priority areas in the study of this disease. Patients with HS need highly effective, safe drugs to maintain stable remission. This article provides an overview of current knowledge of HS, including diagnosis, pathogenesis, and treatment.
Adaptation to the impacts of climate and demographic changes on water supply and demand in Nairobi, Kenya
Authors: Munene Lydia Nduku , Maina Eunice Wanjiku , Singh Babel Mukand , Vojinovic Zoran , Gersonius Berry 
Published: September 2024

ABSTRACT

Uncertainties due to the impacts of climate change on water resources and demographic rise, pose challenges to the decision-making process in the management of water resources for urban cities thus, adequate planning ought to incorporate uncertainties. The study objective was to develop adaptation pathways using the Climate Risk Informed Decision Analysis (CRIDA) approach to enhance the water system performance. Using the hydrological model for the Thika-Chania Sub-catchment, prediction of future water flows for 30 years period was done. A multivariate econometric approach was used to investigate the socio-economic factors on water use and forecasts on future water demand. The demand scenarios were based on different population growth patterns corresponding to the exponential growth and decreasing rate of increase growth, with per capita consumption scenarios of 85 and 170 lpd. The system performance was evaluated through stress testing to determine the behavior under different scenarios. Results revealed an increasing supply–demand gap due to the impacts of climate and demographic changes. Adaptation strategies and their tipping points were established leading to the development of adaptation pathways. From assessment of the flexible adaptation pathways, it was concluded that the non-revenue water strategy be considered as a priority project by the utility.
Wastewater reclamation for the production of construction bricks: technical, economic, and environmental feasibility
Authors: Centeno Mora Erick , Padilla Carlos Montero , Cruz Zúñiga Nidia 
Published: September 2024

ABSTRACT

This study evaluates the technical, economic, and environmental impacts of using treated wastewater as a substitute for potable water (PW) in mortar bricks production. The study experimentally compared the reuse of raw sewage, UASB reactor effluent, activated sludge effluent, and filtered effluent to produce mortar bricks which were tested for mixture workability and compressive strength over curing periods of 3, 7, and 28 days. Slump values of the mixtures were close to 110 mm for all samples, and 28-day compressive strengths varied between 31.2 and 34.8 MPa, higher than the 17.2 MPa required for Type M mortars. Mortar made with activated sludge and filtered effluent exhibited properties comparable to those made with PW. Economic analysis revealed a slight cost increase of 1.7% due to effluent disinfection, but significant environmental benefits, such as reduced eutrophication due to the wastewater reclamation and water conservation, were noted, primarily due to the avoidance of discharging treated effluent into surface water bodies. These findings underscore the feasibility of using treated wastewater in construction, highlighting its potential to enhance sustainability in this field, and suggesting the necessity for further studies on the long-term effect of using reclaimed wastewater cementitious products.
Biocompatible Electrospun Hydrogel Fibers for Advanced Wound Healing Therapies
Authors: Yadav Pragya , Gupta Manas , Singh Satya Prakash , Parashar Poonam 
Published: September 2024

:
Wound healing is a complex cascade and is governed through a number of crucial factors. Conventional
wound dressing possesses numerous limitations which hinder wound healing process and may result in
serious infections and even mortality. A lot of effort have been put in through researchers to develop a multifaceted
dressing which can address these limitations and facilitate accelerated wound healing. Among various
newly developed dressings, electrospun hydrogel nanofibers have emerged as a promising class of biomaterials
for advanced wound care and tissue engineering applications. These biomimetic fibers closely mimic the
architect of the native extracellular matrix, providing an optimal environment that facilitates cellular proliferation
and fast generation required for effective wound healing. Electrospinning offers versatility in precisely
controlling fiber attributes such as diameter, alignment, and surface morphology and can entrap a variety of
drugs with high efficacy. Recently, such dressings have advanced through the incorporation of smart features
such as stimuli-responsive components, real-time wound monitoring sensors, and smart closed-loop systems.
The electrospun hydrogels are bestowed with extreme porosity, water-retention attribute, biocompatibility, and
modified drug release which make them superior over other wound dressings. The review gives an insight of
electrospun hydrogel fibers and their application in wound healing and the studies assessing wound healing potential
with underlying mechanisms have been critically analysed. Electrospun hydrogel fibers have significant
potential to revolutionize wound care through their biomimetic structure, versatile customization, and capacity
for integrating therapeutic and sensing capabilities, outlining future research directions toward next-generation
wound care products.
Transformative Potential and Healthcare Applications of 3D Printing
Authors: Prakash Aayush , Malviya Rishabha , Singh Deependra Pratap 
Published: September 2024

:
Additive manufacturing, sometimes referred to as 3D printing or AM, has numerous applications in
industries like manufacturing, aviation, aerospace, vehicles, and education. It has recently made considerable
inroads into the healthcare industry, backed by technology breakthroughs such as fused deposition modeling,
binder jetting, and inkjet printing. A variety of biomaterials, such as polycaprolactone, polycarbonate, polypropylene,
and polylactic acid, have contributed to this increase. This essay delves into the revolutionary possibilities
of 3D printing in healthcare, to shed light on the idea of customized medications via the improvement
of efficiency and cost. Researchers are using polymers and additive manufacturing to make customized medical
devices. However, obstacles including bureaucratic hurdles, technological developments, and the choice of
appropriate materials and printers stand in the way of widespread implementation. To fully realize the promise
of 3D printing in healthcare, these challenges must be overcome. The article highlights the revolutionary potential
of 3D printing in healthcare by following its development from art and construction to customized drugs
and patient-specific medical equipment. In addition to addressing issues like quality control and technological
limitations, it emphasizes its wide range of applications in surgical planning, dentistry, and anatomical models.
The necessity of adapting regulations and instructional programs is highlighted by discussing future trends like
bioprinting and FDA-approved innovations. In order to properly utilize 3D printing in healthcare, this adaption
is essential. Personalized prescriptions and increased efficacy from the incorporation of 3D printing could revolutionize
the healthcare industry. But even with these advances, problems like choosing the right materials and
getting over administrative roadblocks prevent widespread implementation. These challenges need to be successfully
overcome for 3D printing in healthcare to reach its full potential.
The Potential of Emerging Medicinal Plants and their Phytoconstituents in Treating Alzheimer's Disease
Authors: Agarwal Uma , Tonk Rajiv K. , Bhutani Rubina , Pannu Arzoo , S.L. Neha , Verma Ashish K. 
Published: September 2024

Backgrounds:
Alzheimer's disease (AD) impacts a total of 30 million individuals
worldwide, resulting in the impairment of brain cells. Despite the approval of medications, there are
still poor results and adverse effects that continue to exist, which has led to continued research for
more effective treatments.

Objectives:
In this study prioritize the medicinal plants and their bioactive chemicals to attract researchers
and pharmaceutical companies interested in producing powerful herbal medicines and
semi-synthetic drugs for the treatment of Alzheimer's disease, although minimizing any potential
adverse effects.

Methods:
This review investigate the effective use of medicinal plants and their phytochemicals in
the treatment of AD to manage its growth and relieve symptoms via improving cognitive deficits.

Results:
These medicinal plants and their phytochemicals contribute to the treatment of AD by protecting
against cell damage induced by beta amyloid, improving memory and learning abilities,
functioning as nerve tonics, and exhibiting strong antioxidant and anti-inflammatory activities. Furthermore,
they have demonstrated therapeutic benefits in the management of AD. The finding suggests
that several phytoconstituents/ plant metabolites are present in numerous anti-Alzheimer's
plants known for their anti-Alzheimer's properties such as rosmarinic acid, quercetin, kaempferol,
gallic acid, β-sitosterol, oleic acid and linalool. In addition, this article emphasizes the anti-
Alzheimer's disease significance of various important phytochemicals.

Conclusions:
The review proposes that medicinal plants and their bioactive phytochemicals hold potential
as a viable alternative treatment for AD. The utilization of these medicinal plants can improve
memory and decrease the likelihood of developing Alzheimer's disease in the future.
Navigating the Aquatic Challenges: Tribal Communities in India's Quest for Sustainable Solutions
Authors: Balkrishna Acharya , Sharma Nidhi , Arya Vedpriya 
Published: September 2024

:
India hosts the world's largest population of Scheduled Tribes (STs), constituting 8.6%
of its total populace and comprising about 700 distinct tribes. Despite their cultural richness and
environmental stewardship, tribal communities face significant socio-economic challenges, with
47% living below the poverty line. Predominantly residing in rural areas, these communities suffer
from acute water scarcity and poor water quality. Only 20% of ST households have access to
drinking water within their premises, and over 33% must travel long distances for water, exacerbating
their vulnerability to waterborne diseases like diarrhea, cholera, and typhoid. Efforts by the
Indian government, including the Ministry of Tribal Affairs and the Ministry of Jal Shakti, have
aimed to improve water access and quality through initiatives, such as the Jal Jeevan Mission and
watershed management programs. However, traditional water management strategies often fail to
address the unique geographical and cultural contexts of tribal regions. This paper explores the
multifaceted challenges of water scarcity and quality in India's tribal areas, analyzing the socioeconomic,
cultural, and geographic factors contributing to these issues. By synthesizing data and
research findings, it aims to provide a comprehensive understanding of the water-related hardships
faced by tribal communities and to offer insights for policymakers and stakeholders to develop
more effective, culturally sensitive, and sustainable water management solutions.
TOKSISITAS EKSTRAK CAMPURAN BIJI JARAK PAGAR DAN SERAI WANGI TERHADAP Callosobruchus chinensis
Authors: Ardiansyah Sigit , Nuryanti Ni Siluh Putu , Wahyudi Anung 
Published: September 2024

Callosobruchus chinensis L. merupakan hama gudang yang dapat menurunkan kualitas dan kuantitas produksi kacang hijau. Biasanya pengendalian C. chinensis dengan insektisida kimia, namun cara tersebut dapat menyebabkan masalah lingkungan dan risiko keamanan pangan. Sehingga, perlu pengadaan insektisida alternatif yang lebih aman dan ramah lingkungan yaitu menggunakan insektisida nabati. Biji jarak pagar dan serai wangi memiliki potensi yang besar sebagai insektisida nabati. Penelitian bertujuan untuk menguji toksisitas, penghambatan peneluran dan sifat interaksi ekstrak campuran biji jarak pagar dan serai wangi dalam berbagai rasio sebagai insektisida nabati terhadap hama C. chinensis pada biji kacang hijau. Metode penelitian meliputi perbanyakkan C. chinensis, pembuatan ekstrak, formulasi insektisida nabati, uji toksisitas ekstrak tunggal dan campuran, uji penghambatan peneluran, dan uji kompatibilitas ekstrak campuran. Hasil Penelitian menunjukkan bahwa toksisitas ekstrak campuran biji jarak pagar dan serai wangi pada rasio 2 : 1 lebih toksik daripada rasio 1 : 2 dan 1 : 1. Ekstrak campuran biji jarak pagar dan serai wangi pada rasio 2 :1 dengan konsentarsi 1% mampu menghambat peneluran sebesar 100%, Sifat Interaksi ekstrak campuran biji jarak pagar dan serai wangi terhadap C. chinensis terbaik pada rasio 2:1, sifat interaksi pada LC50 sinergi kuat dan pada LC95 sinergi lemah.
PERFORMA AGRONOMI TANAMAN JAGUNG YANG BERASAL DARI BENIH HIBRIDA REGENERASI
Authors: Sipi Surianto , Meithasari Dian 
Published: September 2024

Praktek budidaya jagung menggunakan benih turunan hibrida sudah umum dilakukan oleh petani jagung di Indonesia. Petani memilih menanam benih regenerasi karena pertimbangan harga benih hibrida F1 yang mahal dan sulit diperoleh khususnya bagi petani di wilayah timur Indonesia seperti Papua. Tujuan penelitian untuk melihat perbedaan performa agronomi antara generasi F1 dan F2 tiga varietas jagung hibrida yang banyak disebarluaskan melalui komersialisasi dan program diseminasi. Parameter yang diamati meliputi: umur berbunga, tinggi tanaman, jumlah buku, posisi tongkol, panjang tongkol, diameter tongkol, jumlah baris dan bobot biji per tongkol. Hasil penelitian menunjukkan adanya perubahan performa beberapa parameter agronomi tanaman jagung yang berasal dari generasi F2. Perubahan performa agronomi paling banyak terjadi pada generasi F2 varietas JH 27 meliputi: penurunan tinggi tanaman, posisi tongkol, diameter tongkol dan bobot biji per tongkol, serta pengurangan jumlah buku. Perubahan yang signifikan pada generasi F2 varietas Bima URI meliputi: peningkatan jumlah buku dan posisi tongkol serta penurunan diameter tongkol. Perubahan performa agronomi yang signifikan pada generasi F2 varietas Nasa 29 meliputi: penurunan tinggi tanaman dan posisi tongkol serta pengurangan jumlah buku dan panjang tongkol.