bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived Interpersonal Dimensions and Its Effect on Rating Bias: How Neuroticism as a Trait Matters in Rating Creative Works
Authors: Cheng Kevin H. C. 
Published: September 2016

AbstractUnderstanding any inter‐ and intra‐personal dynamic that affects bias in the judgment of creative output is among numerous areas of focus for researchers in Psychology (or subset field). Notably, as a result of changes in interpersonal dynamics, conditions of subjective construal can induce bias either leniently or severely without any due awareness by the evaluator. Based on 153 Cantonese‐English bilinguals, the present study explored two potentially relevant conditions in each of two separate experiments. The first condition (N = 90) examined whether the perceived dominance of the creator differentially affected individuals high in neuroticism in rating involving creativity performance. A generic and robust measure of creativity performance was operationalized and transformed to a score representing the extent the bias was embedded in the rating. In the second condition (N = 63), the perceived friendliness of the evaluation target was manipulated and neuroticism was also assessed. The results indicated raters low in neuroticism exhibited lenient rating bias irrespective of the perceived friendliness or dominance of the rating target. Raters high in neuroticism reported severe rating bias when their targets were perceived as non‐dominant. The study demonstrates the application of the meta‐theoretical framework of the cognitive‐affective personality system. The discussion also emphasizes how the results contribute to development in creativity research—namely the perception and evaluation of creativity. Practical implications of using the findings in managing public expectations from art works to human resource management are posited.
Yeast factories for the production of aromatic compounds: from building blocks to plant secondary metabolites
Authors: Suástegui Miguel , Shao Zengyi 
Published: September 2016

Abstract
The aromatic amino acid biosynthesis pathway is a source to a plethora of commercially relevant chemicals with very diverse industrial applications. Tremendous efforts in microbial engineering have led to the production of compounds ranging from small aromatic molecular building blocks all the way to intricate plant secondary metabolites. Particularly, the yeast Saccharomyces cerevisiae has been a great model organism given its superior capability to heterologously express long metabolic pathways, especially the ones containing cytochrome P450 enzymes. This review contains a collection of state-of-the-art metabolic engineering work devoted towards unraveling the mechanisms for enhancing the flux of carbon into the aromatic pathway. Some of the molecules discussed include the polymer precursor muconic acid, as well as important nutraceuticals (flavonoids and stilbenoids), and opium-derived drugs (benzylisoquinoline alkaloids).
Treatment with pentosan polysulphate in patients with MPS I: results from an open label, randomized, monocentric phase II study
Authors: Hennermann Julia B. , Gökce Seyfullah , Solyom Alexander , Mengel Eugen , Schuchman Edward H. , Simonaro Calogera M. 
Published: September 2016

AbstractCurrent treatment options for MPS I have limited effects on some organs, including the skeletal system. In MPS animal models pentosan polysulphate (PPS) reduces the concentrations of glycosaminoglycans (GAGs) in tissues and body fluids and improves cartilaginous and osseous pathologies. The goals of this study were to investigate primarily the safety and secondary the clinical effects, concerning mobility and pain, of PPS treatment in MPS I patients. Four MPS I‐Hurler‐Scheie/‐Scheie patients aged 35.6 ± 6.4 years with one male were included in the study. All patients were on enzyme replacement therapy since 9.45 ± 3.75 years. PPS was applied subcutaneously in two patients with 1 mg/kg and in two patients with 2 mg/kg, weekly for 12 weeks and then biweekly for 12 weeks. The 24‐week treatment with PPS was well tolerated by all patients. Urinary GAG concentrations were reduced from 4.13 ± 1.17 at baseline to 2.69 ± 0.36 mg/mmol creatinine after 24‐week treatment with 1 mg/kg PPS, and from 6.71 ± 0.62 to 2.65 ± 0.09 mg/mmol creatinine with 2 mg/kg PPS. An improvement in range of motion was noted in three out of four patients. The pain intensity score was reduced from 4.5 ± 1.77 at baseline to 1.8 ± 0.47 after 24‐week treatment with 1 mg/kg PPS; patients with 2 mg/kg PPS already had minimal pain at the start of the study. In conclusion, PPS treatment in a small number of adult MPS I patients was well tolerated and resulted in a significant reduction of urinary GAG excretion and in an improvement of joint mobility and pain.
Forest–farm edge effects on communities of ground beetles (Coleoptera: Carabidae) under different landscape structures
Authors: Jung Jong‐Kook , Lee Joon‐Ho 
Published: September 2016

AbstractIn fragmented landscapes, ecological processes may be significantly influenced by edge effects, but few data are available for edge effects across forest–farmland edges. We investigated patterns of species richness, abundance, and species composition in ground beetles across forest–farm edges in two different agro‐forest landscapes in Korea. Nine and five sites were selected from Hwaseong, a fragmented landscape, in 2011 and 2012, respectively, while eight sites were selected from Hoengseong, a relatively well‐protected landscape, in 2012. Ground beetles were collected by pitfall trapping. Species richness was higher in the surrounding habitat than in the forest interior or edge in both Hwaseong and Hoengseong. However, in Hwaseong, species richness of the forest edge was similar to that of the forest interior, while in Hoengseong forest edge species richness was intermediate between that of the forest interior and surrounding areas. In addition, non‐metric multidimensional scaling based on the combined data of both locations showed that the species composition of ground beetles in the forest edge was more similar to that of the forest interior than the surrounding areas, although some open‐habitat species occurred at the forest edges. Three characteristic groups (forest specialists, edge‐associated species, and open‐habitat species) of ground beetle species were detected by indicator value analysis. In our study, ground beetle assemblages differed in the forest edges of two agro‐forest landscapes, suggesting that the edge effect on biota can be influenced by landscape structure.
Experimental Study of In‐Situ CO2Foam Technique and Application in Yangsanmu Oilfield
Authors: Jin Fayang , Liu Zhezhi , Pu Wanfen , Zhong Dong , Yuan ChengDong , Wei Bing 
Published: September 2016

AbstractThe Yangsanmu oilfield of Dagang is a typical heavy oil reservoir. After the maximum primary production (waterflooding), more than half of the original oil is still retained in the formation. Therefore, the implementation of an enhanced oil recovery (EOR) process to further raise the production scheme is inevitable. In this work, a novel in‐situ CO2foam technique which can be used as a potential EOR technique in this oilfield was studied. A screening of gas producers, foam stabilizers and foaming agents was followed by the study of the properties of the in‐situ CO2foam systems through static experiments. Core‐flooding experiments and field application were also conducted to evaluate the feasibility of this technique. The results indicated that the in‐situ CO2foam system can improve both the sweep and displacement efficiencies, due to the capacity of this system in reducing oil viscosity and interfacial tension, respectively. The EOR performance of the in‐situ CO2foam system is better than the single‐agent and even binary system (surfactant‐polymer) flooding. The filed data demonstrated that the in‐situ CO2technique can significantly promote oil production and control water cuts. These results are believed to be beneficial in making EOR strategies for similar reservoirs.
Eco‐friendly Pretreatment of Oil with High Free Fatty Acid Content Using a Sulfamic Acid/Ethanol System
Authors: de Oliveira Patrick Martins , Farias Luana Machado , Morón‐Villarreyes Joaquín A. , Montes D'Oca Marcelo G. 
Published: September 2016

AbstractIn recent years, sulfamic acid (SA, NH2SO3H) has emerged as a novel green catalyst for organic synthesis because of several advantages, including its non‐volatility, non‐hygroscopicity, non‐corrosivity, and low cost. This work reports the use of sulfamic acid as a catalyst in the pretreatment of oil with a high content of free fatty acids (10 and 20 % FFA) in ethanol or methanol. The process (esterification reaction) used in the pretreatment of the oil was carried out under a variety of conditions, initial fatty acid content, temperature, type of alcohol, and % catalyst. The experiments using an NH2SO3H/ethanol system resulted in a high fatty acid ethyl ester conversion, 88.53 % (±0.95) from an initial acidity of 40 mg KOH/g (20 % FFA), using 8 % NH2SO3H as the catalyst. According to the results, the methodology using sulfamic acid and ethanol demonstrated elevated potential for a environmentally‐friendly means of biodiesel production.
Characterizing a lubricant additive for 1,3,4-tri-(2-octyldodecyl) cyclopentane: Computational study and experimental verification
Authors: Nian Jingyan , Si Yifan , Guo Zhiguang , Gao Ping , Liu Weimin 
Published: September 2016

Abstract
In order to increase the life of spacecraft, it is important to improve the comprehensive lubrication performance. Multiple alkylated cyclopentane (MAC) lubricants are presently gaining wide acceptance for actual space applications; adding extreme pressure additive is a strategy to improve lubrication performance. In this study, taking 1,3,4-tri-(2-octyldodecyl) cyclopentane as base oil, tricresol phosphate (traditional additive) and tri-(2-octyldodecyl) phosphate (developmental additive) have been screened computationally for compatibility, shear film forming and energy dissipation. Theoretical results indicate that (a) tricresol phosphate additive is not suited for addition to 1,3,4-tri-(2-octyldodecyl) cyclopentane lubricant due to limited compatibility; (b) tri-(2-octyldodecyl) phosphate is an excellent lubricant additive due to its perfect compatibility, ease of forming a shear film on the surface of friction pairs, higher strength, and low energy dissipation; and (c) lubrication occurs through the solid-liquid composite lubrication mechanism. These theoretical results were confirmed experimentally.
Exposure to and Attitudes Regarding Transgender Education Among Urology Residents
Authors: Dy Geolani W. , Osbun Nathan C. , Morrison Shane D. , Grant David W. , Merguerian Paul A. ,   Transgender Education Study Group
Published: September 2016

ABSTRACT

Introduction
Transgender individuals are underserved within the health care system but might increasingly seek urologic care as insurers expand coverage for medical and surgical gender transition.

Aim
To evaluate urology residents' exposure to transgender patient care and their perceived importance of transgender surgical education.

Methods
Urology residents from a representative sample of U.S. training programs were asked to complete a cross-sectional survey from January through March 2016.

Main Outcome Measures
Respondents were queried regarding demographics, transgender curricular exposure (didactic vs clinical), and perceived importance of training opportunities in transgender patient care.

Results
In total, 289 urology residents completed the survey (72% response rate). Fifty-four percent of residents reported exposure to transgender patient care, with more residents from Western (74%) and North Central (72%) sections reporting exposure (P ≤ .01). Exposure occurred more frequently through direct patient interaction rather than through didactic education (psychiatric, 23% vs 7%, P &lt; .001; medical, 17% vs 6%, P &lt; .001; surgical, 33% vs 11%, P &lt; .001). Female residents placed greater importance on gender-confirming surgical training than did their male colleagues (91% vs 70%, P &lt; .001). Compared with Western section residents (88%), those from South Central (60%, P = .002), Southeastern (63%, P = .002), and Mid-Atlantic (63%, P = .003) sections less frequently viewed transgender-related surgical training as important. Most residents (77%) stated transgender-related surgical training should be offered in fellowships.

Conclusion
Urology resident exposure to transgender patient care is regionally dependent. Perceived importance of gender-confirming surgical training varies by sex and geography. A gap exists between the direct transgender patient care urology residencies provide and the didactic transgender education they receive.
Use of a biodegradable, oversized stent in a child with tracheomalacia secondary to vascular external compression
Authors: Di Dedda Giovanni , Mirabile Cristian 
Published: September 2016

AbstractWe describe the implantation of an absorbable, custom-made stent of polydioxanone to treat tracheomalacia in a 5-month-old patient with extrinsic compression by a double aortic arch. The use of an absorbable, oversized stent treated the tracheal collapse caused by vascular compression, avoided removal procedures, and allowed the infant’s growth. The use of an oversized stent prevented stent migration and gave minimal problems of granulation.
Comparison of self-expandable and balloon-expanding stents for hybrid ductal stenting in hypoplastic left heart complex
Authors: Goreczny Sebastian , Qureshi Shakeel A. , Rosenthal Eric , Krasemann Thomas , Nassar Mohamed S. , Anderson David R. , Morgan Gareth J. 
Published: September 2016

AbstractObjectivesWe aimed to compare the procedural and mid-term performance of a specifically designed self-expanding stent with balloon-expandable stents in patients undergoing hybrid palliation for hypoplastic left heart syndrome and its variants.BackgroundThe lack of specifically designed stents has led to off-label use of coronary, biliary, or peripheral stents in the neonatal ductus arteriosus. Recently, a self-expanding stent, specifically designed for use in hypoplastic left heart syndrome, has become available.MethodsWe carried out a retrospective cohort comparison of 69 neonates who underwent hybrid ductal stenting with balloon-expandable and self-expanding stents from December, 2005 to July, 2014.ResultsIn total, 43 balloon-expandable stents were implanted in 41 neonates and more recently 47 self-expanding stents in 28 neonates. In the balloon-expandable stents group, stent-related complications occurred in nine patients (22%), compared with one patient in the self-expanding stent group (4%). During follow-up, percutaneous re-intervention related to the ductal stent was performed in five patients (17%) in the balloon-expandable stent group and seven patients (28%) in self-expanding stents group.ConclusionsHybrid ductal stenting with self-expanding stents produced favourable results when compared with the results obtained with balloon-expandable stents. Immediate additional interventions and follow-up re-interventions were similar in both groups with complications more common in those with balloon-expandable stents.
Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in patients with newly diagnosed multiple myeloma on the ECOG-ACRIN E4A03 randomized clinical trial: long-term follow-up
Authors: Biran N , Jacobus S , Vesole D H , Callander N S , Fonseca R , Williams M E , Abonour R , Katz M S , Rajkumar S V , Greipp P R , Siegel D S 
Published: September 2016

AbstractIn Eastern Cooperative Oncology Group-ACRIN E4A03, on completion of four cycles of therapy, newly diagnosed multiple myeloma patients had the option of proceeding to autologous peripheral blood stem cell transplant (ASCT) or continuing on their assigned therapy lenalidomide plus low-dose dexamethasone (Ld) or lenalidomide plus high-dose dexamethasone (LD). This landmark analysis compared the outcome of 431 patients surviving their first four cycles of therapy pursuing early ASCT to those continuing on their assigned therapy. Survival distributions were estimated using the Kaplan–Meier method and compared with log-rank test. Ninety patients (21%) opted for early ASCT. The 1-, 2-, 3-, 4- and 5-year survival probability estimates were higher for early ASCT versus no early ASCT at 99, 93, 91, 85 and 80% versus 94, 84, 75, 65 and 57%, respectively. The median overall survival (OS) in the early versus no early ASCT group was not reached (NR) versus 5.78 years. In patients <65 years of age, median OS in the early versus no early ASCT groups was NR in both, hazard ratio 0.79, 95% confidence interval: (0.50, 0.25). In patients ⩾65 years of age, median OS in the early versus no early ASCT was NR versus 5.11 years. ASCT dropped out of statistical significance (P=0.080). Patients opting for ASCT after induction Ld/LD had a higher survival probability and improvement in OS regardless of dexamethasone dose density.
A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma
Authors: Bolli N , Li Y , Sathiaseelan V , Raine K , Jones D , Ganly P , Cocito F , Bignell G , Chapman M A , Sperling A S , Anderson K C , Avet-Loiseau H , Minvielle S , Campbell P J , Munshi N C 
Published: September 2016

AbstractGenomic lesions are not investigated during routine diagnostic workup for multiple myeloma (MM). Cytogenetic studies are performed to assess prognosis but with limited impact on therapeutic decisions. Recently, several recurrently mutated genes have been described, but their clinical value remains to be defined. Therefore, clinical-grade strategies to investigate the genomic landscape of myeloma samples are needed to integrate new and old prognostic markers. We developed a target-enrichment strategy followed by next-generation sequencing (NGS) to streamline simultaneous analysis of gene mutations, copy number changes and immunoglobulin heavy chain (IGH) translocations in MM in a high-throughput manner, and validated it in a panel of cell lines. We identified 548 likely oncogenic mutations in 182 genes. By integrating published data sets of NGS in MM, we retrieved a list of genes with significant relevance to myeloma and found that the mutational spectrum of primary samples and MM cell lines is partially overlapping. Gains and losses of chromosomes, chromosomal segments and gene loci were identified with accuracy comparable to conventional arrays, allowing identification of lesions with known prognostic significance. Furthermore, we identified IGH translocations with high positive and negative predictive value. Our approach could allow the identification of novel biomarkers with clinical relevance in myeloma.
Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
Authors: Scholefield Janine , Henriques Ricardo , Savulescu Anca F. , Fontan Elisabeth , Boucharlat Alix , Laplantine Emmanuel , Smahi Asma , Israël Alain , Agou Fabrice , Mhlanga Musa M. 
Published: September 2016

AbstractThe NF-κB pathway has critical roles in cancer, immunity and inflammatory responses. Understanding the mechanism(s) by which mutations in genes involved in the pathway cause disease has provided valuable insight into its regulation, yet many aspects remain unexplained. Several lines of evidence have led to the hypothesis that the regulatory/sensor protein NEMO acts as a biological binary switch. This hypothesis depends on the formation of a higher-order structure, which has yet to be identified using traditional molecular techniques. Here we use super-resolution microscopy to reveal the existence of higher-order NEMO lattice structures dependent on the presence of polyubiquitin chains before NF-κB activation. Such structures may permit proximity-based trans-autophosphorylation, leading to cooperative activation of the signalling cascade. We further show that NF-κB activation results in modification of these structures. Finally, we demonstrate that these structures are abrogated in cells derived from incontinentia pigmenti patients.
Non-destructive imaging of buried electronic interfaces using a decelerated scanning electron beam
Authors: Hirohata Atsufumi , Yamamoto Yasuaki , Murphy Benedict A. , Vick Andrew J. 
Published: September 2016

AbstractRecent progress in nanotechnology enables the production of atomically abrupt interfaces in multilayered junctions, allowing for an increase in the number of transistors in a processor. However, uniform electron transport has not yet been achieved across the entire interfacial area in junctions due to the existence of local defects, causing local heating and reduction in transport efficiency. To date, junction uniformity has been predominantly assessed by cross-sectional transmission electron microscopy, which requires slicing and milling processes that can potentially introduce additional damage and deformation. It is therefore essential to develop an alternative non-destructive method. Here we show a non-destructive technique using scanning electron microscopy to map buried junction properties. By controlling the electron-beam energy, we demonstrate the contrast imaging of local junction resistances at a controlled depth. This technique can be applied to any buried junctions, from conventional semiconductor and metal devices to organic devices.
Morphological and molecular convergences in mammalian phylogenetics
Authors: Zou Zhengting , Zhang Jianzhi 
Published: September 2016

AbstractPhylogenetic trees reconstructed from molecular sequences are often considered more reliable than those reconstructed from morphological characters, in part because convergent evolution, which confounds phylogenetic reconstruction, is believed to be rarer for molecular sequences than for morphologies. However, neither the validity of this belief nor its underlying cause is known. Here comparing thousands of characters of each type that have been used for inferring the phylogeny of mammals, we find that on average morphological characters indeed experience much more convergences than amino acid sites, but this disparity is explained by fewer states per character rather than an intrinsically higher susceptibility to convergence for morphologies than sequences. We show by computer simulation and actual data analysis that a simple method for identifying and removing convergence-prone characters improves phylogenetic accuracy, potentially enabling, when necessary, the inclusion of morphologies and hence fossils for reliable tree inference.
Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra
Authors: Ayton Scott , Lei Peng , Mclean Catriona , Bush Ashley I , Finkelstein David I 
Published: September 2016

AbstractIron deposition in Parkinson’s disease (PD) is a potential disease-modifying target. We previously showed that supplementation of the iron-exporter, ceruloplasmin, selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model. Ceruloplasmin delivers iron to transferrin (Tf), the extracellular iron-transporting protein. We show that Tf protein levels are decreased in the nigra of post-mortem PD brains compared with controls (−35%; n=10 each). Because Tf traffics iron away from iron-replete tissues, we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in PD. In cultured neurons, Tf treatment corrected iron accumulation, and subcutaneous Tf to mice ameliorated iron accumulation and motor deficits in the MPTP model of PD. Although these data support a role for Tf in the disease mechanism for PD, and its potential use for correcting disorders of iron overload, Tf therapy also caused systemic iron depletion, which could limit its application for PD.