bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Patient-reported Outcomes After Laparoscopic Fenestration of Symptomatic Liver Cysts
Authors: Kisiel Aaron , Vass David G. , Navarro Alex , John Annie K. , Isaac Johh , Marudanayagam Ravi , Mirza Darius F. , Muiesan Paolo , Roberts Keith , Sutcliffe Robert P. 
Published: July 2017

Background:
Laparoscopic fenestration is the treatment of choice for symptomatic liver cysts. Despite the benefits of minimally invasive surgery, there is limited data on long-term outcomes after laparoscopic fenestration, in terms of symptom recurrence and quality of life. The purpose of this study was to evaluate long-term patient-reported outcomes and satisfaction following this procedure.

Methods:
All patients who underwent laparoscopic liver cyst fenestration in a single center between 2001 and 2012 were identified from a prospectively maintained database. Long-term patient-reported outcomes including symptom relief and quality of life were prospectively evaluated by a structured telephone interview.

Results:
A total of 98 patients underwent laparoscopic liver cyst fenestration. The median follow-up was 62 months (range, 22 to 173 mo). Follow-up data was available in 48 patients. Four patients developed radiologically confirmed evidence of recurrence with 3 undergoing further surgery. No mortality was reported in the series. Four complications occurred and the median postoperative length of hospital stay was 2 days (range, 1 to 7 d). Thirty-nine patients received immediate symptomatic relief with 98% reporting long-term satisfaction.

Results:
Laparoscopic liver cyst fenestration is associated with low morbidity and long-term alleviation of symptoms. This should be considered the treatment modality of choice in managing patients with nonparasitic cysts.
Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens
Authors: Büerckert Jean-Philippe , Dubois Axel R.S.X. , Faison William J. , Farinelle Sophie , Charpentier Emilie , Sinner Regina , Wienecke-Baldacchino Anke , Muller Claude P. 
Published: July 2017

AbstractThe identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers for tracing back infections, measuring vaccine immunogenicity, and perhaps ultimately allow the reconstruction of the immunological history of an individual. Here, we immunized groups of transgenic rats expressing human Ig against tetanus toxoid (TT), Modified Vaccinia virus Ankara (MVA), measles virus hemagglutinin and fusion proteins expressed on MVA and the environmental carcinogen Benzo[a]Pyrene, coupled to TT. We showed that these antigens impose a selective pressure causing the Ig Heavy chain (IgH) repertoires of the rats to converge towards the expression of antibodies with highly similar IgH CDR3 amino acid sequences. We present a computational approach, similar to differential gene expression analysis, that selects for clusters of CDR3s with 80% similarity, significantly overrepresented within the different groups of immunized rats. These IgH clusters represent antigen-induced IgH signatures exhibiting stereotypic amino acid patterns including previously described TT and measles specific IgH sequences. Our data suggest, that with the presented methodology, transgenic Ig rats can be utilized as a model to identify antigen-induced, human IgH signatures to a variety of different antigens.
Network Curvature as a Hallmark of Brain Structural Connectivity
Authors: Farooq Hamza , Chen Yongxin , Georgiou Tryphon T. , Tannenbaum Allen , Lenglet Christophe 
Published: July 2017

AbstractStudies show that while brain networks are remarkably robust to a variety of adverse events, such as injuries and lesions due to accidents or disease, they may be fragile when the disturbance takes place in specific locations. This seems to be the case for diseases in which accumulated changes in network topology dramatically affect certain sensitive areas. To this end, previous attempts have been made to quantify robustness and fragility of brain functionality in two broadly defined ways: (i) utilizing model-based techniques to predict lesion effects, and (ii) studying empirical effects from brain lesions due to injury or disease. Both directions aim at assessing functional connectivity changes resulting from structural network variations. In the present work, we follow a more geometric viewpoint that is based on a notion of curvature of networks, the so-called Ollivier-Ricci curvature. A similar approach has been used in recent studies to quantify financial market robustness as well as to differentiate biological networks corresponding to cancer cells from normal cells. The same notion of curvature, defined at the node level for brain networks obtained from MRI data, may help identify and characterize the effects of diseases on specific brain regions. In the present paper, we apply the Ollivier-Ricci curvature to brain structural networks to: i) Demonstrate its unique ability to identify robust (or fragile) brain regions in healthy subjects. We compare our results to previously published work which identified a unique set of regions (calledstructural core) of the human cerebral cortex. This novel characterization of brain networks, complementary to measures such as degree, strength, clustering or efficiency, may be particularly useful to detect and monitor candidate areas for targeting by surgery (e.g. deep brain stimulation) or pharmaco-therapeutic agents; ii) Illustrate the power our curvature-derived measures to track changes in brain connectivity with healthy development/aging and; iii) Detect changes in brain structural connectivity in people with Autism Spectrum Disorders (ASD) which are in agreement with previous morphometric MRI studies.
Dynamic gain adjustments in descending corticofugal outputs from auditory cortex compensate for cochlear nerve synaptic damage
Authors: Asokan Meenakshi M , Williamson Ross S , Hancock Kenneth E , Polley Daniel B 
Published: July 2017

AbstractLayer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a compensatory plasticity in L5 auditory cortex (ACtx) projection neurons with axons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We used widefield calcium imaging to monitor daily changes in sound processing from the dense plexus of corticocollicular (CCol) axon terminals in awake adult mice. CCol sound level growth functions were stable in control conditions but showed bi-phasic gain changes following damage to cochlear afferent synapses. Auditory nerve and CCol growth functions were sharply reduced hours after cochlear synaptopathy, but CCol response gain rebounded above baseline levels by the following day and remained elevated for 2 weeks despite a persistent reduction in auditory nerve input. Sustained potentiation of excitatory ACtx projection neurons that innervate multiple limbic and subcortical auditory centers may underlie hyperexcitability and aberrant functional coupling of distributed brain networks in tinnitus.
An Algorithm for Cellular Reprogramming
Authors: Ronquist Scott , Patterson Geoff , Brown Markus , Lindsly Stephen , Chen Haiming , Muir Lindsey A. , Wicha Max , Bloch Anthony , Brockett Roger , Rajapakse Indika 
Published: July 2017

AbstractThe day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton’s laws of motion seems far away. Even so, quantitative approaches to cellular dynamics add to our understanding of cell biology, providing data-guided frameworks that allow us to develop better predictions about, and methods for, control over specific biological processes and system-wide cell behavior. In this paper, we describe an approach to optimizing the use of transcription factors (TFs) in the context of cellular reprogramming. We construct an approximate model for the natural evolution of a cell cycle synchronized population of human fibroblasts, based on data obtained by sampling the expression of 22,083 genes at several time points along the cell cycle. In order to arrive at a model of moderate complexity, we cluster gene expression based on the division of the genome into topologically associating domains (TADs) and then model the dynamics of the TAD expression levels. Based on this dynamical model and known bioinformatics, such as transcription factor binding sites (TFBS) and functions, we develop a methodology for identifying the top transcription factor candidates for a specific cellular reprogramming task. The approach used is based on a device commonly used in optimal control. Our data-guided methodology identifies a number of transcription factors previously validated for reprogramming and/or natural differentiation. Our findings highlight the immense potential of dynamical models, mathematics, and data-guided methodologies for improving strategies for control over biological processes.Significance StatementReprogramming the human genome toward any desirable state is within reach; application of select transcription factors drives cell types toward different lineages in many settings. We introduce the concept of data-guided control in building a universal algorithm for directly reprogramming any human cell type into any other type. Our algorithm is based on time series genome transcription and architecture data and known regulatory activities of transcription factors, with natural dimension reduction using genome architectural features. Our algorithm predicts known reprogramming factors, top candidates for new settings, and ideal timing for application of transcription factors. This framework can be used to develop strategies for tissue regeneration, cancer cell reprogramming, and control of dynamical systems beyond cell biology.
DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers
Authors: Li Wenshuai , Zhang Xu , Lu Xingyu , You Lei , Song Yanqun , Luo Zhongguang , Zhang Jun , Nie Ji , Zheng Wanwei , Xu Diannan , Wang Yaping , Dong Yuanqiang , Yu Shulin , Hong Jun , Shi Jianping , Hao Hankun , Luo Fen , Hua Luchun , Wang Peng , Qian Xiaoping , Yuan Fang , Wei Lianhuan , Cui Ming , Zhang Taiping , Liao Quan , Dai Menghua , Liu Ziwen , Chen Ge , Meckel Katherine , Adhikari Sarbani , Jia Guifang , Bissonnette Marc B. , Zhang Xinxiang , Zhao Yupei , Zhang Wei , He Chuan , Liu Jie 
Published: July 2017

AbstractDNA modifications such as 5-methylcytosines (5mC) and 5-hydroxymethylcytosines (5hmC) are epigenetic marks known to affect global gene expression in mammals(1, 2). Given their prevalence in the human genome, close correlation with gene expression, and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive and selective chemical labeling technology(3), we report here genome-wide 5hmC profiling in circulating cell-free DNA (cfDNA) and in genomic DNA of paired tumor/adjacent tissues collected from a cohort of 90 healthy individuals and 260 patients recently diagnosed with colorectal, gastric, pancreatic, liver, or thyroid cancer. 5hmC was mainly distributed in transcriptionally active regions coincident with open chromatin and permissive histone modifications. Robust cancer-associated 5hmC signatures in cfDNA were identified with specificity for different cancers. 5hmC-based biomarkers of circulating cfDNA demonstrated highly accurate predictive value for patients with colorectal and gastric cancers versus healthy controls, superior to conventional biomarkers, and comparable to 5hmC biomarkers from tissue biopsies. This new strategy could lead to the development of effective blood-based, minimally-invasive cancer diagnosis and prognosis approaches.
Being “adopted” into a teaching community
Authors: Bentley Erinn , Workman Madison , Overby Alex 
Published: July 2017

PurposeIn order to prepare new members of the education profession, it is imperative that teachers enter their classrooms with the confidence, knowledge, and skills to serve their students from day one. One method for preparing such teacher candidates or student teachers is through school-based field placements during their preparation program. The purpose of this paper is to describe one example of a yearlong field placement and the mentoring relationships that emerged among participants.Design/methodology/approachThis qualitative study used the following data sources: focus group interviews among the teacher candidates, focus group interviews among the mentor teachers, field placement reflections and teaching analyses composed by the teacher candidates, and interviews conducted among teacher candidates and mentor teachers.FindingsAnalysis of the data revealed that the yearlong field placement promoted positive mentoring relationships between teacher candidates and their classroom teachers. Specifically the following themes emerged: the “adoption” of teacher candidates into the high school classrooms, risk-taking within the classrooms, the mentor teachers’ use of constructive feedback, and collaborative “mentoring-down-the-hall.”Originality/valueIn recent years, various scholars have investigated the impact of field placement experiences on teacher candidates; however, these studies have lacked a detailed analysis of how such experiences impacted mentoring relationships among candidates and their mentor teachers in a collaborative setting. This paper provides an in-depth study of the perceived experiences of mentor teachers and their candidates.
The impact of service bundles on the mechanism through which functional value and price value affect WOM intent
Authors: Ranaweera Chatura , Karjaluoto Heikki 
Published: July 2017

Purpose
The purpose of this paper is to contribute toward the current limited understanding of service bundles by investigating how purchasers of combined product-service bundles (bundle customers) differ from those purchasing a product and associated service separately (non-bundle customers).

Design/methodology/approach
The hypothesized effects were tested on a representative sample of mobile phone subscribers in Finland, through a multi-group moderated analysis using variance-based structural equation modeling.

Findings
While functional value had a stronger effect on attitude for bundle customers, price value is a stronger determinant of attitude for non-bundle customers. There was no difference between the groups in terms of how attitude determines the word-of-mouth (WOM) intent. The total influence of functional value on positive WOM intent was stronger for bundle customers vs non-bundle customers; in contrast, the total influence of price value on positive WOM was weaker for the bundle customers.

Research limitations/implications
Two interrelated frameworks, prospect theory and mental accounting theory, are used to analyze customer response to service bundles. The results demonstrate that bundles play a powerful role in determining engagement behaviors critical to firms. Purchasing a service bundle vs a non-bundle influences how price value and functional value determine attitude and WOM intent in fundamentally different ways.

Practical implications
In devising communication strategies to maximize positive WOM, managers need to emphasize functional benefits for bundle purchasers and price benefits for non-bundle customers. The results also demonstrate that it is more important for firms to track perceived value, as value and not attitude differentiates WOM generation in the two groups.

Originality/value
This is the first study to demonstrate how bundle and non-bundle customers determine value, and how functional value and price value determine WOM generation and attitude toward service provider in fundamentally different ways. The comparison of the bundle group where the firm acts as the main resource integrator to a non-bundle group where the customer is the main resource integrator in creating value helps demonstrate the need for firms to treat the two groups in distinct ways.
The enhanced loyalty drivers of customers acquired through referral reward programs
Authors: Ramaseshan B. , Wirtz Jochen , Georgi Dominik 
Published: July 2017

PurposeThe purpose of this paper is to extend prior research on referral reward programs (RRPs) by examining if and how the mode of customer acquisition (RRP-acquired customers vs non-RRP-acquired new customers) moderates the relationships between customer satisfaction and attitudinal loyalty, perceived switching costs and attitudinal loyalty, and attitudinal loyalty and behavioral loyalty (i.e. recommendations, cross-buying, and total spend).Design/methodology/approachSet in a banking context, this study is the first in an RRP context to link survey data with actual purchase data from a bank’s CRM records. Specifically, the survey captured customers’ satisfaction, perceived switching costs and attitudinal loyalty, whereas the CRM data provided actual loyalty behaviors (cross-buying and total spend).FindingsThe findings show that the effect of satisfaction on attitudinal loyalty, and the effects of attitudinal loyalty on recommendations, cross-buying, and total spend were stronger for RRP-acquired customers than for non-RRP-acquired new customers. Furthermore, perceived switching costs had a lower effect on attitudinal loyalty for RRP-acquired customers than for non-RRP-acquired new customers.Practical implicationsThe findings offer managers a better understanding of how RRP-acquired customers differ from non-RRP-acquired new customers with regard to their satisfaction, perceived switching costs, and attitudinal and behavioral loyalty, thus enabling effective management of RRPs.Originality/valueThis is the first empirical study that explores the differences between RRP-acquired customers and non-RRP-acquired new customers with regard to the effects of satisfaction and perceived switching costs on attitudinal loyalty, and the effect of attitudinal loyalty on behavioral loyalty.
Children perceptions of emotional and rational appeals in social advertisements
Authors: Nicolini Valentina , Cassia Fabio , Bellotto Massimo 
Published: July 2017

PurposeThis study aims to understand the impact of rational and emotional appeals on children’s attitude towards two public service announcements (PSAs) that promoted eating fruits and vegetables.Design/methodology/approachA mixed-methods study was conducted with children aged 8 to 11. A convergent parallel design was selected that comprised a questionnaire for the quantitative approach and a semi-structured focus group for the qualitative approach.FindingsThe results from the quantitative and qualitative phases converged, showing that both components (i.e. emotional and rational) play a significant role in children’s preference towards an advertisement, but the emotional component appeared to be the preeminent.Research limitations/implicationsFuture studies should use other social subjects and children of different age brackets from various countries to test whether they continue to prefer emotional appeals in advertising.Practical implicationsAn understanding of which elements children prefer in PSAs will enable advertising campaigns and social marketing strategies with targeted approaches that respect children’s tastes to be planned.Social implicationsA properly designed social advertisement could have important effects on disseminating useful information, changing or preventing unhealthy habits and adopting good practices in children.Originality/valueFew studies have examined the effectiveness of PSAs, especially those targeted at children. This paper contributes to extend concepts from the commercial field of advertising directed to children to the field of social advertising. To date, this field has received little attention.
Undergraduates’ responses to factors affecting their money management behaviour: some new insights from a qualitative study
Authors: Bamforth Jill , Jebarajakirthy Charles , Geursen Gus 
Published: July 2017

Purpose
The money management behaviour of undergraduates is a noteworthy study for many stakeholders, as these students are more likely to carry forward this behaviour into later life. The literature on student money management behaviour heavily focuses on financial literacy. However, economic, social and psychological factors also affect undergraduates’ money management behaviour. Therefore, the purpose of this study is to empirically investigate how undergraduates respond to and account for these factors in their money management behaviour.

Design/methodology/approach
This study was carried out in Australia. This study adopted a qualitative exploratory approach. The data were collected using six focus group discussions (FGDs) held in one Australian university, in which 40 undergraduates participated.

Findings
The key themes identified from the thematic analysis include undergraduates’ understanding of money management and managing economic, social and psychological aspects relating to undergraduates’ money management behaviour. Several subthemes were identified under each theme, which specifically showed how undergraduates manage and respond to each of these factors relating to their money management behaviour.

Research limitations/implications
This study was conducted with the data collected from a relatively small sample of respondents and was limited only to undergraduates. Moreover, this study was conducted in Australia, indicating that some of the results might be specific to the Australian context.

Practical implications
The authors have suggested promoting multiple payment methods and internet usage to undergraduates, and providing them with stress management programmes will help them maintain prudent money management behaviour.

Originality/value
The extant literature on undergraduates’ money management behaviour tends to focus on financial literacy. This study extends the scope of the literature beyond financial literacy and has shown how undergraduates respond to economic, social and psychological aspects relating to money management behaviour. This study has applied a qualitative exploratory approach, in contrast to quantitative methods which have generally been applied for studies relating to undergraduates’ money management behaviour.