bluuebunny/crossref_metadata_2025_split huggingface dataset:
APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy (C) plus trastuzumab (T) plus placebo (Pla) versus chemotherapy plus trastuzumab (T) plus pertuzumab (P) as adjuvant therapy in patients (pts) with HER2-positive early breast cancer (EBC).
Authors: Von Minckwitz Gunter , Procter Marion Jennifer , De Azambuja Evandro , Zardavas Dimitrios , Knott Adam , Viale Giuseppe , Suter Thomas M. , Arahmani Amal , Rouchet Nathalie , Clark Emma , Benyunes Mark , Lang Istvan , Levy Christelle , Yardley Denise A. , Bines Jose , Gelber Richard D. , Piccart-Gebhart Martine J. , Baselga Jose 
Published: June 2017

LBA500 Background: In previous trials P significantly prolonged progression free and overall survival and increased pCR rates when added to T+C in pts with HER2-positive breast cancer (BC). The APHINITY trial was designed to test whether the addition of P to adjuvant T+C improves pt outcomes. Methods: Pts with adequately excised HER2-positive, pT1-3 EBC were randomly assigned to receive standard adjuvant C plus one year of either T + P or T + Pla. Eligible pts had either node-positive disease, or node-negative disease (pN0) and a tumor size of > 1.0 cm. Pts with pN0, T1b tumors with high risk features were initially eligible. The primary efficacy endpoint was invasive disease-free survival (IDFS); we assumed a 3-year IDFS of 91.8% with P and 89,.2% with Pla. Results: 4805 pts were randomized to C and T plus either P (n = 2400) or Pla (n = 2405). Baseline demographics and tumor characteristics between the arms were well balanced, with 63% and 36% of pts having node-positive and hormone receptor negative EBC respectively. P and Pla treatments were completed in 84.5% and 87.4% of patients, respectively. IDFS events occurred in 171 (7.1%) P pts and 210 (8.7%) Pla pts (hazard ratio (HR) 0.81 (95% CI 0.68-1.00), P = 0.045). Estimates of IDFS at 3 years were 94.1% and 93.2% in the P and Pla arms, respectively. The node-positive cohort had a 3-year IDFS rate of 92.0% for P compared with 90.2% for Pla (HR 0.77 (95% CI 0.62-0.96), P = 0.019). The pN0 cohort had a 3-year IDFS rate of 97.5% for P and 98.4% for Pla; HR = 1.13 (95% CI 0.68-1.86). The safety profile of P was consistent with previous trials. For the primary cardiac endpoint (heart failure or cardiac death) and secondary cardiac endpoint (asymptomatic or mildly symptomatic LVEF decline) rates were low, 0.7% vs 0.3% and 2.7% vs 2.8%, in the P and Pla arms, respectively. Diarrhea grade ≥3 was more frequent with P (9.9% vs 3.7%). Conclusions: The APHINITY trial met its primary endpoint: P significantly improved IDFS in patients with HER2-positive EBC when added to T+C. No new safety signals were identified. Clinical trial information: NCT01358877.
Adding abiraterone for men with high-risk prostate cancer (PCa) starting long-term androgen deprivation therapy (ADT): Survival results from STAMPEDE (NCT00268476).
Authors: James Nicholas D. , De Bono Johann S. , Spears Melissa Ruth , Clarke Noel , Mason Malcolm David , Dearnaley David P. , Ritchie Alastair W S , Russell J. Martin , Gilson Clare , Jones Robert J. , Gillessen Silke , Matheson David , Aung San , Birtle Alison J. , Chowdhury Simon , Gale Joanna , Malik Zafar , O'Sullivan Joe M. , Parmar Mahesh K B , Sydes Matthew Robert 
Published: June 2017

LBA5003 Background: Abiraterone showed a survival advantage in men with castration-refractory prostate cancer. We assessed whether abiraterone would work earlier in the disease. STAMPEDE is a randomized controlled trial using a multi-arm multi-stage platform design. It recruits patients (pts) with high-risk locally advanced or metastatic PCa starting long-term ADT. We report the first comparative survival data. Methods: The standard-of-care (SOC) was ADT for 2+yrs; radiotherapy (RT) was mandated for men with N0M0 disease & encouraged for N+M0. Stratified randomization allocated pts 1:1 to SOC or SOC+abiraterone 1000mg + prednisolone 5mg daily. Treatment duration depended on stage & intent to give radical RT: pts not having RT or M1 disease, treatment continued until PSA, radiological & clinical progression; otherwise treatment continued until the earlier of 2 years or all types of progression. The primary outcome measure was death from any cause. Comparison to control for survival had 90% power at 2.5% 1-sided alpha for hazard ratio (HR) of 0.75, requiring ~267 control arm deaths, accounting for 3 intermediate lack-of-benefit analyses on failure-free survival (FFS). Analyses used Cox proportional hazards & flexible parametric models, adjusted for stratification factors. Results: 1,917 pts were contemporaneously randomized to these arms (Nov 2011- Jan 2014). Groups were balanced: median age 67yrs; 52% metastatic, 20% N+/X M0, 28% N0M0; 95% newly-diagnosed; median PSA 53ng/ml. Median follow-up was 40m. There were 262 control arm deaths (82% PCa). The adjusted HR = 0.63 (95% CI 0.52-0.76; p=0.115x10-7; 184 deaths) for SOC+Abi vs SOC, with 3yr OS improved from 76% to 83%. There were 535 control arm FFS events; the adjusted HR = 0.29 (95% CI 0.25-0.34; p = 0.377x10-63, 248 FFS events) for SOC+Abi vs SOC. Grade 3 & 4 adverse events were seen in 29% & 3% SOC, 41% & 5% SOC+Abi; Grade 5: 3 & 9 (1 & 2 related). Conclusions: The results show a clinically & statistically significant effect on overall survival & failure-free survival from adding abiraterone at start of ADT with a manageable increase in toxicity. ADT (+/- RT) + abiraterone is a new standard of care for this group. Clinical trial information: NCT00268476.
Data of physiological measurements and quality of life in subjects with mild to moderate COPD compared to asymptomatic current smokers, former smokers and never-smokers
Authors: Chaudhary Nveed , Luettich Karsta , Peck Michael J. , Pierri Elena , Felber-Medlin Loyse , Vuillaume Gregory , Leroy Patrice , Hoeng Julia , Peitsch Manuel C. 
Published: June 2017

Chronic obstructive pulmonary disease (COPD) is a common inflammatory airway disease predominantly associated with cigarette smoking, and its incidence is increasing worldwide. According to the Global Initiative for Obstructive Lung Disease (GOLD) guidelines, spirometry is used to diagnose the disease. However, owing to its complexity, spirometry alone may not account for the multitude of COPD phenotypes or the early, asymptomatic lung damage seen in younger smokers. In addition, suitable biomarkers enabling early diagnosis, guiding treatment and estimating prognosis are still scarce, although large scale ‘omics analyses have added to the spectrum of potential biomarkers that could be used for these purposes. The aim of the current study was to comprehensively profile patients with mild-to-moderate COPD and compare the profiles to i) a group of currently smoking asymptomatic subjects, ii) a group of healthy former smokers, and iii) a group of healthy subjects that had never smoked. The assessment was conducted at the molecular level using proteomics, transcriptomics, and lipidomics and complemented by a series of measurements of traditional and emerging indicators of lung health (ClinicalTrials.gov identifier: NCT01780298). In this data note, we provide a comprehensive description of the study population’s physiological characteristics including full lung function, lung appearance on chest computed tomography, impulse oscillometry, and exercise tolerance and quality of life (QoL) measures.
Case Article—A Prescription for Budget Woes at Gracious University Hospital
Authors: Hicklin Karen , Ivy Julie S. , Vila-Parrish Anita R. 
Published: June 2017

This case study focuses on pharmacy operations from the standpoint of the chief financial officer for Gracious University Hospital. Her charge was to reduce operational expenses on top of pre-established budget cuts. Her first order of business was to handle inventory of the automated dispensing cabinets (ADCs) located on each floor of the hospital which contains a limited supply of medication supplied by the central pharmacy. In order to develop an effective inventory plan, a tiger team was developed consisting of physicians, patients, nurses, and pharmacists who developed a physical simulation competition between hospital unit floors which focused on the medication delivery process from prescription entry to medication administration. While observing the process, data would be captured and teams would attempt to derive better inventory policies for the medications kept in the ADCs. This case introduces students to healthcare operations by providing background on pharmacy medication delivery systems. The learning objectives of the case and accompanying simulation activity are to (1) explore the challenges of inventory management in healthcare (2) develop and analyze inventory policies based on data collection and observation (3) understand the impact of variability and perishability on inventory management. An electronic companion is available at https://doi.org/10.1287/ited.2016.0159ca .
Analyst Information Discovery and Interpretation Roles: A Topic Modeling Approach
Authors: Huang Allen H. , Lehavy Reuven , Zang Amy Y. , Zheng Rong 
Published: June 2017

This study examines analyst information intermediary roles using a textual analysis of analyst reports and corporate disclosures. We employ a topic modeling methodology from computational linguistic research to compare the thematic content of a large sample of analyst reports issued promptly after earnings conference calls with the content of the calls themselves. We show that analysts discuss exclusive topics beyond those from conference calls and interpret topics from conference calls. In addition, we find that investors place a greater value on new information in analyst reports when managers face greater incentives to withhold value-relevant information. Analyst interpretation is particularly valuable when the processing costs of conference call information increase. Finally, we document that investors react to analyst report content that simply confirms managers’ conference call discussions. Overall, our study shows that analysts play the information intermediary roles by discovering information beyond corporate disclosures and by clarifying and confirming corporate disclosures. The Internet appendix is available at https://doi.org/10.1287/mnsc.2017.2751 . This paper was accepted by Suraj Srinivasan, accounting.
Equivalent Inventory Metrics: A Behavioral Perspective
Authors: Stangl Tobias , Thonemann Ulrich W. 
Published: June 2017

We analyze how performance metrics that contain equivalent information affect actual decisions. We consider two such performance metrics from supply chain management, days of supply and inventory turn rate, where one is the inverse of the other. We argue that individuals’ assessment of performance is also affected by the metric as opposed to solely based on the inventory value that actually matters. We perform three laboratory studies and analyze how decisions are affected by the metric used to indicate inventory performance. The first study considers alternative inventory optimizations, out of which one must be selected. The second study analyzes a decision maker who must decide on the effort to invest in optimizing inventory of a specific product. The third study corresponds to the economic order quantity model. Our behavioral models suggest that decisions are affected by the metric that is used to indicate performance, and we find support for the predictions in laboratory experiments with human subjects: Under the inventory turn rate metric, individuals overvalue inventory reductions. Compared to decisions under the days of supply metric, they choose worse inventory optimization options, invest more effort optimizing inventory of specific products, and choose higher ordering cost. The e-companion is available at https://doi.org/10.1287/msom.2017.0620 .
Predictors of Risky Behavior and Offending for Adolescents With Mild Intellectual Disability
Authors: Savage Melissa N. , Bouck Emily C. 
Published: June 2017

Abstract
Adolescents with intellectual disability (ID) engage in risky behavior and offending. However, little is known on the impact school-related predictors have on engagement in risky behaviors for adolescents with ID. This study analyzed secondary data from the National Longitudinal Transition Study-2 (NLTS2) to determine levels of engagement in risky behaviors and offending for adolescents with mild and moderate/severe ID. School-related predictors of engagement for adolescents with mild ID were also explored. Results indicated adolescents with mild ID engage in risky behaviors and offending at significantly higher rates as compared to adolescents with moderate/severe ID. Participation in a social skills or life skills class was a significant predictor of less engagement in risky behaviors for individuals with mild ID.
Parent Perspectives of Applying Mindfulness-Based Stress Reduction Strategies to Special Education
Authors: Burke Meghan M. , Chan Neilson , Neece Cameron L. 
Published: June 2017

Abstract
Parents of children with (versus without) intellectual and developmental disabilities report greater stress; such stress may be exacerbated by dissatisfaction with school services, poor parent-school partnerships, and the need for parent advocacy. Increasingly, mindfulness interventions have been used to reduce parent stress. However, it is unclear whether parents apply mindfulness strategies during the special education process to reduce school-related stress. To investigate whether mindfulness may reduce school-related stress, interviews were conducted with 26 parents of children with intellectual and developmental disabilities who completed a mindfulness-based stress reduction intervention. Participants were asked about their stress during meetings with the school, use of mindfulness strategies in communicating with the school, and the impact of such strategies. The majority of parent participants reported: special education meetings were stressful; they used mindfulness strategies during IEP meetings; and such strategies affected parents' perceptions of improvements in personal well-being, advocacy, family-school relationships, and access to services for their children. Implications for future research, policy, and practice are discussed.
Expressões idiomáticas em dicionários bilíngues pedagógicos francês-português brasileiro: uma análise comparativa por amostragem das letras A e P
Authors: Parreira Maria Cristina , Robayo García Maria Camila , Chrispolim Júlia Garcia 
Published: June 2017

Este estudo decorre do trabalho prático da colaboração internacional com uma editora que propôs um dicionário bilíngue pedagógico contemplando a variante brasileira do português com a língua francesa. O trabalho gerou um corpus de 102 arquivos .DOC do qual foram compiladas as unidades fraseológicas em novo corpus, aqui denominado corpus Kernerman, em arquivos .XLS, contendo 2696 linhas de A a Z, das quais foram selecionadas as letras A e P. Autores como Zuluaga (1980), Corpas Pastor (1997), Xatara (1998b), Ortiz Álvares (2000), Biderman (2001, 2005), Krieger (2006), Welker (2006, 2011) e Xatara e Parreira (2011) constituíram o arcabouço teórico da pesquisa. A análise consiste na identificação dessas unidades e no levantamento das expressões idiomáticas, para comparação quantitativa do material em dicionários bilíngues usuais no Brasil, das editoras Larousse (2005) e Melhoramentos (2002), com a hipótese de que, nos dicionários mais antigos, não há tratamento adequado dessa parcela do léxico, como os dados demonstraram ao final.
Annular split level shear tester sebagai alat pengukur karakteristik aliran bahan padat butiran
Authors: Sasongko Setia Budi 
Published: June 2017

Jenike Shear Tester telah dikenal dengan baik sebagai suatu instrumen untuk mengetahui sifat pengaliran dari suatu bahan padat butiran. Hasil pengukuran bahan berdasarkan Jenike Shear Tester ini telah direkomendasikan sebagai suatu standar. Akan tetapi instrument ini memiliki eberapa keterbatasan antara lain: keterbatasan untuk geseran horizontal demikian juga dengan jumlah titik untuk membuat kurve patahan, diperlukan beberapa sample untuk membuat kurve patahan, dan juga adanya ketidak uniform antara bagian yang dekat dengan cincin dengan bagian tengah cincin. Untuk mengatasi hal ini, kemudian Peshcl mengembangkan shear tester jenis totational (RO 200), akan tetapi pada kenyataan masih terdapat beberapa kelemahan. Dengan mengurangi kelemahan yang terdapat pada Peschl Shear Tester, maka pada penelitian ini, dikembangkan Shear Tester jenis Annular Split Level dengan hasil pengukuran yang mendekati hasil Jenike Shear Tester.Keyword : Shear Tester, Rotational Shear Tester, Annular Split Level Shear Tester
Parameter Kga- Enhancement Factor Dalam Sistem Absorbs CO2 Dengan Larutan NaOH
Authors: Hadiyanto Hadiyanto , K. Andri C. , Djaeni Moh. 
Published: June 2017

Absorbsi merupakan proses perpindahan massa untuk memisahkan suatu gas dari campurannya dengan cairan penyerap NaOH, MEA atau K2CO3. Pada penelitian ini, campuran gas yang mengandung CO2 dikontakkan dengan larutan NaOH sebagai penyerap dalam suatu kolom unggun tetap. Penelitian ini juga mempelajari pengaruh laju alir larutan NaOH sebesar 0,026-0,042 liter /detik dan suhu operasi 30-70 0C. Sedangkan tekanan, laju alir gas udara, jenis dan ukuran packing serta komposisi awal CO2 (56,8%) dijaga tetap.Analisis secara fisis dan fisis-kimia dilakukan dengan suatu model mathematic untuk menentukan koefisien perpindahan massa gas-cair (kga), enhangement factor (E) dantetapan-tetapan perancangan yang lain. Koefisien –koefisien tersebut ditentukan untuk melengkapi data-data perancangan kolom absorbs CO2, yang lebih akurat dan sesuai untuk diterapkan dalam industri.Hasil penelitian menunjukkan bahwa harga koefisien perpindahan massa (kga)untuk absorbs gas CO2 dengan NaOH dipengaruhi oleh laju alir cairan penyerap dan temperature. Semakin besar laju alir maka harga kga makin besar pula dan semakin tinggi temperatur makaharga kga juga semakin besar. Harga kga yang didapat berkisar antara 2,44x 10-2 sampai 5,77x 10-2 untuk variabel proses T= 30-70 0C dan laju alir cairan 0,026 -0,042 l/detik. Sedangkan untuk Enhancement factor (E) berkisar antara 4,2156 sampai 7,1414.Kata kunci : Absorpsi, kga, Enhancement factor
Pemakaian Asam Askorbat Untuk Produksi Koenzim Quinine Dengan Induksi Sel Nicotiana Tabaccum
Authors: Nurdin Said , Huzaimi Afnizar 
Published: June 2017

Koenzim quinine merupakan produk intraseluler nicotiana tobaccum, sehingga untuk mengisolasikannya diperlukan penambahan antioksidan. Penelitian penambahan antioksidan berupa sam askobat dengan variasi konsentrasi bertujuan untuk menyelidiki tingkat efektifitas pemakaian senyawa tersebut dengan proses induksi sel menurut perubahan waktu. Proses induksi berlangsung melalui penambahan inokulum ke dalam nutrient sampai terbentukkan callus. Callus dipindahkan ke dalam media pemeliharaan yang telah diberikan nutrien, sehingga tumbuh dan berkembang menjadi sel baru. Pertumbuhan sel di dalam medium cair diamati melalui berat sel segar yang diperoleh. Perkembangan berat sel segar dan produksi koenzim quinine kasar pada berbagai konsentrasi vitamin C tersebut ditentukan dengan menggunakan HPLC dan pendeteksiannya spectrometer Shimadzu SPD-10 A pada panjang gelombang 275 nm. Hasil pembentukan koenzim quinine diuji pada hari ke- 1, 3, 5,6 dan 7 dengan konsentrasi 0,5 mg/l. nilai optimalnya dicapai sebesar 0,3598 ppm, 0,3641 ppm, 0,3675 ppm, 0,3699 ppm dan 0,3718 ppm, dan pada konsentrasi asam askorbat = 0,7 mg/l menunjukkan produksi koenzim quinine, sbanyak 0,3920 ppm, 0,3791 ppm, 0,3996 ppm, 0,4005 ppm dam 0,4030 ppm.Kata kunci : asam askorbat, antioksidan, coenzim quinine, induksi sel, nicotiana tabaccum, inokulum, nutrient, callus, medium
Pengaruh Waktu Tunggal Biomassa (SRT) Terhadap Kualitas Limbah Cair Indistri Tekstil Dengan Proses Lumpur Aktif-Membran
Authors: Suwardiyono Suwardiyono 
Published: June 2017

Penelitian proses gabungan lumpur aktif- membrane ini merupakan penggabungan proses lumpur aktif konvensional, dalam rangka upaya peningkatan kinerja proses. Dalam system ini, membrane berfungsi sebagai pengganti bak sedimentasi. Proses pengolahan diharapkan bias beroprasi pada konsentrasi biomassa dan waktu tinggal iomassa yang tinggi serta menghasilkan sitem yang kompak.Pada penelitian ini digunakan limbah cair industry tekstil dengan COD 795-1148 mg/l dan mikroorganisme dari sistem proses lumpur aktif konvensional. Proses membrane yang digunakan adalah mikrofiltrasi crossflow dengan modul hollow fiber terbuat dari polipropilen,ukuran pori 0,2 mikron dan luas permukaan membran 0,0226 m2. Proses pengolahan berlangsung pada waktu tinggal cairan (hydraulic retention time, HRT) tetap 9 jam dan waktu tinggal lumpur ( solid retention time, SRT) divariasikan, yaitu 24, 32, 40, dan 48 hari. Dengan variasi SRT tersebut dapat diketahui pengaruh SRT terhadap kinerja proses dan kualitas keluaran.Kondisi proses membrane pada penelitian ini TMP 0,4 bar dan laju alir silang 0,88 m/s serta tekanan back backflushing 1,6 bar, selang waktu 1,5 menit dan lama back fluching 1 detik. Dengan kondisi ini, diperoleh fluks stabil 5,04 l/(jam.m2) pada berbagai SRT. Pada keadaan tunak, didapatkan MLSS semakin besar, dengan peningkatan SRT. Konsentrasi COD keluaran semakin kecil seiring dengan kenaikan SRT, yaitu pada SRT 24,32, 40 dan 48 hari berturut-turut 198, 126,79 dan 38 mg/ l. Dan efisiensi penyisihan COD yang diperoleh semakin besar seiring dengan kenaikan SRT, yaitu pada SRT 24, 32, 40, dan 48 hari berturut-turut 80,85%; 87,59%; 92,08% dan 96,26%.Kata kunci : kualitas limbah, limbah cair, proses lumpur aktif-membran, waktu tinggal biomassa (solid retention time, SRT)
Pemanfaatan Hati Dan Biji Kapuk Serta Asam Lemak Bebas Untuk Pembuatan Sabun Lunak
Authors: Pandia Setiaty 
Published: June 2017

Hati dan biji kapuk dapat dimanfaatkan sebagai basa alternatif, demikian pula asam lemak bebas (ALB) sebagai sumber lemak untuk pembuatan sabun lunak. Perlakuan awal dilakukan terhadap basa dari hati dan biji kapuk berupa pemisahan K dan Na, demikian pula dengan sumber lemak dari asam lemak bebas melalui tahap proses hidrogenasi asam lemak tak jenuhnya.Dengan memvariasikan jumlah basa dan lemak yang digunakan, pada kondisi pembakaran 400 0C, waktu perendaman 18 hari, rasio massa abu hasil pembakaran dengan air sebesar 1 : 1 serta campuran basa (16 gram kristal KOH dan 10 gram ekstrak basa) dengan 80 gram asam lemak bebas dan 5,5 gram H2O2, diperoleh sabun lunak dengan kandungan alkali bebas 0,12%, lemak tak tersabunkan 2,45% asam lemak bebas 88,3% serta pH 7,07. Kata kunci : Asam Lemak Bebas (ALB), hati dan biji kapuk, hidrogenasi, pembakaran dan ekstraksi, sabun lunak, saponifikasi
The moving-slab Heating in the furnace for various production plans
Authors: Istadi Istadi , Bindar Y. , Koswara Koswara 
Published: June 2017

The reheating furnace in occasional production time has to be charged with slabs having fifferent sizes in length, ridth and thickness. This production plan was put due to economical and productivity consideration. Moreover in the future development, the slab grade might be improved to hight grades. It is our expectation that the furnace can be fire for different production plans above. The strategy for firing the burners from zone to zone has to be determined precisely to meet the designed heating curves for the various slab. A suggest to guide in the formulations of the furnace firing strategy was developed in this work. This suggestion is based on three-dimentional mathematical model for heated slab in the furnace. This mathematical model was coded for the computational simulation. The code was able to simulate furnacthree-dimentional effect of fuenace operational parameters and variety of slab length group. The result reasonably represent the slab-heating curve for different operational parameters. Unsymmetrical firing practices can be shown their effect to the 3D temperature distribution of the slab. Keywords : 3Dtemperature distribution, reheating furnace, slab heating, slab length group