bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m
Authors: Garousi Javad , Lindbo Sarah , Mitran Bogdan , Buijs Jos , Vorobyeva Anzhelika , Orlova Anna , Tolmachev Vladimir , Hober Sophia 
Published: November 2017

AbstractABD-Derived Affinity Proteins (ADAPTs) is a novel class of engineered scaffold proteins derived from an albumin-binding domain of protein G. The use of ADAPT6 derivatives as targeting moiety have provided excellent preclinical radionuclide imaging of human epidermal growth factor 2 (HER2) tumor xenografts. Previous studies have demonstrated that selection of nuclide and chelator for its conjugation has an appreciable effect on imaging properties of scaffold proteins. In this study we performed a comparative evaluation of the anti-HER2 ADAPT having an aspartate-glutamate-alanine-valine-aspartate-alanine-asparagine-serine (DEAVDANS) N-terminal sequence and labeled at C-terminus with 99mTc using a cysteine-containing peptide based chelator, glycine-serine-serine-cysteine (GSSC), and a similar variant labeled with 111In using a maleimido derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator. Both 99mTc-DEAVDANS-ADAPT6-GSSC and 111In-DEAVDANS-ADAPT6-GSSC-DOTA accumulated specifically in HER2-expressing SKOV3 xenografts. The tumor uptake of both variants did not differ significantly and average values were in the range of 19–21%ID/g. However, there was an appreciable variation in uptake of conjugates in normal tissues that resulted in a notable difference in the tumor-to-organ ratios. The 111In-DOTA label provided 2–6 fold higher tumor-to-organ ratios than 99mTc-GSSC and is therefore the preferable label for ADAPTs.
Enhanced and Stable Upconverted White-light Emission in Ho3+/Yb3+/Tm3+-doped LiNbO3 Single Crystal via Mg2+ Ion Doping
Authors: Xing Lili , Yang Weiqi , Lin Jincheng , Huang Mei , Xue Yuqi 
Published: November 2017

AbstractA strategy to enhance the upconversion white-light intensity via Mg2+ ion doping was demonstrated in Ho3+/Yb3+/Tm3+/LiNbO3 single crystal. It is found Mg2+ ion doping affects the crystal field symmetry around RE3+ ions and enhance the upconversion emission intensity. Bright white-light is obtained when the Mg2+ ion concentration is 0.5 mol% in the melt. And the CIE coordinates are hardly changed with Mg2+ ion doping. In addition, the upconversion mechanism is discussed in detail. It is observed the longer lifetimes of intermediate levels result in the lower upconversion photon numbers, which are beneficial to the upconversion process. Therefore, Mg2+ ion doped Ho3+/Yb3+/Tm3+/LiNbO3 single crystals would have potential applications in stable white-light devices and photoelectric instruments.
Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context
Authors: Saladino Raffaele , Bizzarri Bruno M. , Botta Lorenzo , Šponer Jiří , Šponer Judit E. , Georgelin Thomas , Jaber Maguy , Rigaud Baptiste , Kapralov Mikhail , Timoshenko Gennady N. , Rozanov Alexei , Krasavin Eugene , Timperio Anna Maria , Mauro Ernesto Di 
Published: November 2017

AbstractThe formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo- and 2′-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate the presumptive conditions in space or on an early Earth fluxed by slow protons from the solar wind, potentially mimicking a plausible prebiotic scenario. The reaction (i) requires neither pre-activated precursors nor intermediate purification/concentration steps, (ii) is based on a defined radical mechanism, and (iii) is characterized by stereoselectivity, regioselectivity and (poly)glycosylation. The yield is enhanced by formamide and meteorite relative to the control reaction.
Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous system
Authors: Francescatto Margherita , Lizio Marina , Philippens Ingrid , Pardo Luba M. , Bontrop Ronald , Sakai Mizuho , Watanabe Shoko , Itoh Masayoshi , Hasegawa Akira , Lassmann Timo , Severin Jessica , Harshbarger Jayson , Abugessaisa Imad , Kasukawa Takeya , Carninci Piero , Hayashizaki Yoshihide , Forrest Alistair R. R. , Kawaji Hideya , Rizzu Patrizia , Heutink Peter 
Published: October 2017

AbstractRhesus macaque was the second non-human primate whose genome has been fully sequenced and is one of the most used model organisms to study human biology and disease, thanks to the close evolutionary relationship between the two species. But compared to human, where several previously unknown RNAs have been uncovered, the macaque transcriptome is less studied. Publicly available RNA expression resources for macaque are limited, even for brain, which is highly relevant to study human cognitive abilities. In an effort to complement those resources, FANTOM5 profiled 15 distinct anatomical regions of the aged macaque central nervous system using Cap Analysis of Gene Expression, a high-resolution, annotation-independent technology that allows monitoring of transcription initiation events with high accuracy. We identified 25,869 CAGE peaks, representing bona fide promoters. For each peak we provide detailed annotation, expanding the landscape of ‘known’ macaque genes, and we show concrete examples on how to use the resulting data. We believe this data represents a useful resource to understand the central nervous system in macaque.
A dataset quantifying polypharmacy in the United States
Authors: Quinn Katie J. , Shah Nigam H. 
Published: October 2017

AbstractPolypharmacy is increasingly common in the United States, and contributes to the substantial burden of drug-related morbidity. Yet real-world polypharmacy patterns remain poorly characterized. We have counted the incidence of multi-drug combinations observed in four billion patient-months of outpatient prescription drug claims from 2007–2014 in the Truven Health MarketScan® Databases. Prescriptions are grouped into discrete windows of concomitant drug exposure, which are used to count exposure incidences for combinations of up to five drug ingredients or ATC drug classes. Among patients taking any prescription drug, half are exposed to two or more drugs, and 5% are exposed to 8 or more. The most common multi-drug combinations treat manifestations of metabolic syndrome. Patients are exposed to unique drug combinations in 10% of all exposure windows. Our analysis of multi-drug exposure incidences provides a detailed summary of polypharmacy in a large US cohort, which can prioritize common drug combinations for future safety and efficacy studies.
Electrochemical properties of NiCoO2synthesized by hydrothermal method
Authors: Wang Xianwei , Li Weixia , Wang Xiaoer , Zhang Jingjie , Sun Lingyun , Gao Chang , Shang Jun , Hu Yanchun , Zhu Qianqian 
Published: November 2017

NiCoO2microspheres were successfully synthesizedviaan easy hydrothermal method, followed by an annealing process at 350 °C under a nitrogen atmosphere.
Three-dimensional Fusion Imaging without Contrast Medium for Carotid Endarterectomy
Authors: Mizutani Tohru , Sumi Kenji , Shimizu Katsuyoshi , Matsumoto Masaki 
Published: November 2017

AbstractCarotid endarterectomy (CEA) is a popular surgical procedure for patients with carotid artery stenosis. Before performing CEA, radiologic information about carotid artery stenosis must be obtained using three-dimensional (3D) computed tomography angiography (CTA). However, it is difficult to perform 3D-CTA in patients with renal dysfunction and an allergy to contrast medium. To solve this problem, 3D fusion images (3D-FI) with magnetic resonance angiography and 3D computed tomography are created. In this report, we describe the utility of 3D-FI.
Rates and Locations of Regional Metastases in Sinonasal Malignancies: The Mayo Clinic Experience
Authors: Peck Brandon , Van Abel Kathryn , Moore Eric , Price Daniel 
Published: November 2017

Objectives The objective of this study was to identify factors that may influence the rate and location of regional metastasis in sinonasal malignancies (SNMs).
Design This is a retrospective review.
Setting This study was set at the single-institution tertiary referral center.
Participants A total of 299 patients were treated for SNMs from 1994 to 2014.
Main Outcome Measures The main outcome measures were incidence and distribution of regional metastases.
Results Several histologic subtypes were treated, with squamous cell carcinoma (28.4%), esthesioneuroblastoma (18.1%), and mucosal melanoma (12.4%) being the most common. Of the 299 patients, 59 (19.7%) developed a regional metastasis, either at presentation or during follow-up. Higher cumulative incidence of regional metastases was significantly associated with histologic type (p ≤0.001) and invasion of the dura (p = 0.005), infratemporal fossa (p = 0.036), orbit (p = 0.020), or palate (p = 0.016). Ipsilateral level II lymph nodes were the most commonly involved nodes. Contralateral regional metastases were associated with higher risk histologic types (p = 0.005) and dural invasion (p = 0.008). Parotid metastases were associated with invasion of the facial soft tissue (p = 0.028), and retropharyngeal metastases were associated with invasion of the pterygoid plates and musculature (p = 0.030).
Conclusion Histologic type of SNM appears to be the most important factor in predicting the rate of regional metastases. Histologic type and invasion of certain neighboring structures may help define which lymphatic basins are at highest risk for metastasis.
Locoregional Therapy for Hepatic Neuroendocrine Metastases
Authors: Bercu Zachary , Mitchell Jason , Camacho Juan , Kies Darren , Friedberg Eric , Martin Charles , Prologo J. 
Published: November 2017

AbstractNeuroendocrine tumors are a heterogeneous group of malignancies with diverse biological and clinical behavior. Locoregional treatments available for the initial and temporal management of neuroendocrine tumors involving the liver include transarterial embolization, transarterial chemoembolization, selective internal radiotherapy, and ablative techniques. These therapies are best employed as part of a multidisciplinary management team focusing on appropriate histopathology, timing, and individuality of each intervention.
Application of texture inheritance on manufacturing ultra-high strength pearlitic steel wire
Authors: Fang Feng , Wang Liping , Zhou Lichu , Min Xuegang , Jiang Jianqing 
Published: November 2017

To obtain both ultra-high strength and good ductility in pearlitic steel wires, a new processing technique was proposed following the principle of inherited texture. Microstructure evolution of pearlitic wires was investigated by FE-SEM, EBSD and TEM, and while mechanical properties were determined by tensile and torsional tests. Two types of wires with different ferrite <110> texture intensity were obtained by varying pre-drawing strain. The orientation between ferrite <110> and drawing direction exhibited a great effect on the deformation behaviour of pearlite. For the ferrite <110> parallel to drawing direction, cementite lamellae were straightened and dislocations within ferrite were evenly distributed. However, for the ferrite <110> at an angle to drawing direction, the cementite was bent and the distribution of dislocations within ferrite was uneven. Consequently, pearlitic wires with a higher texture level exhibited an extremely high tensile strength, coupled with a remarkable torsion tolerance. This is part of a thematic issue on Pearlitic Steel Wires.
Application of response surface methodology for optimizing evacuation time in enclosed car park
Authors: Tharima Ahmad Faiz , Rahman Md Mujibur , Yusoff Mohd Zamri 
Published: November 2017

Abstract
Smoke fills the car park area due to smoke back layering occurred during a fire. The presence of the beam which leads to the smoke back layering phenomena is investigated to remain smoke layer longer at the upper level with fewer occurrences of backflow. In the current study, a combination of Design of Experiment (DOE); Central Composite Design, (CCD) and statistical tools Response Surface Methodology, (RSM) were utilised to evaluate an optimal design for longer smoke residing time. The Fire Dynamic Simulator (FDS), a CFD model for the fire-driven fluid flow, was employed as a flow simulation tool. The result of six replication model produced by DOE, the error that ranged from 0.48% to 1.77% indicating that the model is reliable. It was also found that the polynomial regression result was linear with predicted R2 of 97.64%, which was within the actual R2 (99.45%). The effects of five control parameters such as ceiling height, beam spacing, transversal beam, extraction rate and longitudinal beam on the smoke descend time has been found to be significant. In the optimal design, the smoke remained longer at the upper level with the percentage of improvement 217.95%. The contribution of the study is the time measured in this analysis is adequate within the beam span only. Interestingly, it effects to the overall geometry with having a lengthier time of smoke to descend. The polynomial model should be used for future engineering design in an enclosed car park.
Estimation of QTL heritability based on pooled sequencing data
Authors: Tang Weiqi , Huang Likun , Bu Suhong , Zhang Xuzhang , Wu Weiren 
Published: November 2017

AbstractMotivationBulked segregant analysis combined with next generation sequencing has proven to be a simple and efficient approach for fast mapping of quantitative trait loci (QTLs). However, how to estimate the proportion of phenotypic variance explained by a QTL (or termed QTL heritability) in such pooled QTL mapping is an unsolved problem.ResultsIn this paper, we propose a method called PQHE to estimate QTL heritability using pooled sequencing data obtained under different experimental designs. Simulation studies indicated that our method is correct and feasible. Four practical examples from rice and yeast are demonstrated, each representing a different situation.Availability and implementationThe R scripts of our method are open source under GPLv3 license at http://genetics.fafu.edu.cn/PQHE or https://github.com/biotangweiqi/PQHE. The R scripts require the R package rootSolve.Supplementary informationSupplementary data are available at Bioinformatics online.
Using Contact Theory to Assess Staff Perspectives on Training Initiatives of an Intergenerational Programming Intervention
Authors: Weaver Raven H , Naar Jill J , Jarrott Shannon E 
Published: November 2017

Abstract

Background and Objectives
Project TRIP (Transforming Relationships through Intergenerational Programs) was developed as a sustainable intergenerational community project involving child care participants and elders attending an elder care program or volunteering at the children’s program. The project focused on staff development of evidence-based intergenerational practices. To enhance available intervention research, contact theory provided a theoretical framework to explore how staff members’ and administrators’ perceptions of the intervention influenced their ability to implement programming in social care settings.

Research Design and Methods
We used a directed content analysis approach to analyze small group and individual interviews with 32 participants from 6 program sites over 5 years.

Results
Participants highlighted inherent challenges and subsequent benefits of academic–community partnerships. Greater on-site presence, open communication, and relationship-building proved critical to improve community partnerships, project fidelity, and program sustainability. When interactions reflected contact theory tenets, collaborators reported positive attitudes toward and interactions with research partners.

Discussion and Implications
Contact theory provided a useful framework to understand the researcher–practitioner partnership. Researchers should plan for partnerships that: (a) are supported by authority figures, including staff and participants, (b) utilize a shared expertise approach where partners have equal group status, (c) involve close cooperation; (d) align research and program goals, and (e) foster positive communication through frequent contact using practitioners’ preferred methods and including in-person contact. We recommend future intergenerational programming interventions build on a foundation of both theory and practice.
Robotic Stereotaxy in Cranial Neurosurgery: A Qualitative Systematic Review
Authors: Fomenko Anton , Serletis Demitre 
Published: November 2017

Abstract

BACKGROUND
Modern-day stereotactic techniques have evolved to tackle the neurosurgical challenge of accurately and reproducibly accessing specific brain targets. Neurosurgical advances have been made in synergy with sophisticated technological developments and engineering innovations such as automated robotic platforms. Robotic systems offer a unique combination of dexterity, durability, indefatigability, and precision.

OBJECTIVE
To perform a systematic review of robotic integration for cranial stereotactic guidance in neurosurgery. Specifically, we comprehensively analyze the strengths and weaknesses of a spectrum of robotic technologies, past and present, including details pertaining to each system's kinematic specifications and targeting accuracy profiles.

METHODS
Eligible articles on human clinical applications of cranial robotic-guided stereotactic systems between 1985 and 2017 were extracted from several electronic databases, with a focus on stereotactic biopsy procedures, stereoelectroencephalography, and deep brain stimulation electrode insertion.

RESULTS
Cranial robotic stereotactic systems feature serial or parallel architectures with 4 to 7 degrees of freedom, and frame-based or frameless registration. Indications for robotic assistance are diversifying, and include stereotactic biopsy, deep brain stimulation and stereoelectroencephalography electrode placement, ventriculostomy, and ablation procedures. Complication rates are low, and mainly consist of hemorrhage. Newer systems benefit from increasing targeting accuracy, intraoperative imaging ability, improved safety profiles, and reduced operating times.

CONCLUSION
We highlight emerging future directions pertaining to the integration of robotic technologies into future neurosurgical procedures. Notably, a trend toward miniaturization, cost-effectiveness, frameless registration, and increasing safety and accuracy characterize successful stereotactic robotic technologies.
Galaxy interactions trigger rapid black hole growth: An unprecedented view from the Hyper Suprime-Cam survey
Authors: Goulding Andy D , Greene Jenny E , Bezanson Rachel , Greco Johnny , Johnson Sean , Leauthaud Alexie , Matsuoka Yoshiki , Medezinski Elinor , Price-Whelan Adrian M 
Published: October 2017

Abstract
Collisions and interactions between gas-rich galaxies are thought to be pivotal stages in their formation and evolution, causing the rapid production of new stars, and possibly serving as a mechanism for fueling supermassive black holes (BHs). Harnessing the exquisite spatial resolution (∼0${^{\prime\prime}_{.}}$5) afforded by the first ∼170 deg2 of the Hyper Suprime-Cam (HSC) survey, we present our new constraints on the importance of galaxy–galaxy major mergers (1 : 4) in growing BHs throughout the last ∼8 Gyr. Utilizing mid-infrared observations in the WISE all-sky survey, we robustly select active galactic nuclei (AGN) and mass-matched control galaxy samples, totaling ∼140000 spectroscopically confirmed systems at i &lt; 22 mag. We identify galaxy interaction signatures using a novel machine-learning random forest decision tree technique allowing us to select statistically significant samples of major mergers, minor mergers / irregular systems, and non-interacting galaxies. We use these samples to show that galaxies undergoing mergers are a factor of ∼2–7 more likely to contain luminous obscured AGN than non-interacting galaxies, and this is independent of both stellar mass and redshift to z &lt; 0.9. Furthermore, based on our comparison of AGN fractions in mass-matched samples, we determine that the most luminous AGN population (LAGN ≳ 1045 erg s−1) systematically reside in merging systems over non-interacting galaxies. Our findings show that galaxy–galaxy interactions do, on average, trigger luminous AGN activity substantially more often than in secularly evolving non-interacting galaxies, and we further suggest that the BH growth rate may be closely tied to the dynamical time of the merger system.
Cervical Sagittal Range of Motion as a Predictor of Symptom Severity in Cervical Spondylotic Myelopathy
Authors: Nicholson Kristen J. , Millhouse Paul W. , Pflug Emily , Woods Barrett , Schroeder Gregory D. , Anderson D. Greg , Hilibrand Alan S. , Kepler Christopher K. , Kurd Mark F. , Rihn Jeffrey A. , Vaccaro Alexander , Radcliff Kris E. 
Published: November 2017

Study Design.
A retrospective review of radiographic data and functional outcomes.

Objective.
The aim of this study was to evaluate whether myelopathy symptom severity upon presentation corresponds to sagittal plane alignment or nonmyelopathy symptoms, such as pain, in patients with cervical spondylotic myelopathy (CSM).

Summary of Background Data.
Cervical sagittal balance is an important parameter in the outcome of surgical reconstruction. However, the effect of sagittal alignment on symptom severity in patients who have not undergone spine surgery is not well defined.

Methods.
A consecutive series of CSM patients was identified at an academic institution. Preoperative radiographs were analyzed for sagittal vertical axis (C2SVA), C7 slope (C7S), C2-C7 angle in neutral (C27N), flexion (C27F), and extension (C27E), and range of motion (C27ROM). Neutral alignment was categorized as lordotic, kyphotic, or sigmoid/straight. Outcomes collected were SF-12, neck disability index, arm pain, neck pain, and modified JOA (mJOA). Pearson coefficients determined correlations between radiographic and outcome parameters. Multivariate regression evaluated predictive factors of mJOA.

Results.
Radiographic parameters did not correlate with pain. Increasing age, smaller C27ROM, and smaller flexion angles correlated to lower (more severe) baseline mJOA scores. ROM (and not static alignment) was the only significant predictor of mJOA in the multivariate regression. Despite significant radiographic differences between lordotic, kyphotic, and sigmoid/straight alignment groups, myelopathy severity did not differ between these groups.

Conclusion.
Static, neutral alignment, including SVA and lordosis, did not correlate with myelopathy or pain symptoms. Greater C27ROM and increased maximal flexion corresponded to milder myelopathy symptoms, suggesting that patients with myelopathy may compensate for cervical stenosis with hyperflexion, similar to that which is observed in the lumbar spine. In a CSM patient population, dynamic motion and compensatory deformities may play a more significant role in myelopathy symptom severity than what can be discerned from standard, neutral position radiographs.

Level of Evidence: 3