bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYSTERY AND THE EVIDENTIAL IMPACT OF UNEXPLAINABLES
Authors: Klein Dominik , Colombo Matteo 
Published: May 2017

ABSTRACTWhat's the evidential impact of learning that something is a mystery? To answer this question, we first explicate the notion of a mystery in terms of unexplainability. After distinguishing different ways in which something can be unexplainable, we develop a test to evaluate the evidential impact of two distinct types of unexplainables: symmetrical and asymmetrical unexplainables. We argue that only asymmetrical unexplainables have evidential impact. We finally clarify how our explication of mysteries as unexplainables complements existing accounts of abduction and contributes to the literature on the mystery of consciousness.
Maternal protein restriction depresses the duodenal expression of iron transporters and serum iron level in male weaning piglets
Authors: Ma Wenqiang , Lu Jingyu , Jiang Shuxia , Cai Demin , Pan Shifeng , Jia Yimin , Zhao Ruqian 
Published: May 2017

AbstractTo investigate the effects of maternal dietary protein restriction on offspring Fe metabolism, twenty-four second-parity Landrace×Yorkshire sows were randomly allocated to standard-protein (SP) and low-protein (LP) groups. The SP sows were fed diets containing 15 and 18 % crude protein throughout pregnancy and lactation, respectively, whereas the LP sows were subjected to 50 % dietary protein restriction. Offspring birth weight was not affected, but the body weight at weaning (P=0·06) and average daily gain (P=0·01) of the female piglets were significantly decreased. Serum Fe level in the LP piglets was markedly decreased at weaning, especially in males (P=0·03). Serum ferritin level (P=0·08) tended to be lower, yet serum transferrin was greatly higher (P=0·01) in male weaning piglets of the LP group. Duodenal expression of the divalent metal transporter 1 (DMT1) and ferroportin (FPN) was surprisingly reduced (P<0·05) at the level of protein, but not at the mRNA level, in male weaning piglets of the LP group. Male weaning piglets born to the LP sows exhibited higher hepatic hepcidin levels (P=0·09), lower hepatic expression of transferrin (P<0·01) and transferrin receptor 1 (P<0·05) at the level of mRNA. However, no significant differences were observed for hepatic Fe storage, ferritin, transferrin and transferrin receptor 1 protein expression in male weaning piglets of the two groups. These results indicate that maternal protein restriction during pregnancy and lactation influences growth of female offspring at weaning, reduces duodenal expression of Fe transporters (DMT1 and FPN) and decreases serum Fe level in male weaning piglets.
Global phylogenetic relationships, population structure and gene flow estimation of Trialeurodes vaporariorum (Greenhouse whitefly)
Authors: Wainaina J.M. , De Barro P. , Kubatko L. , Kehoe M. A. , Harvey J. , Karanja D. , Boykin L. M. 
Published: May 2017

AbstractTrialeurodes vaporariorum (Westwood, 1856) (Greenhouse whitefly) is an agricultural pest of global importance. It is associated with damage to plants during feeding and subsequent virus transmission. Yet, global phylogenetic relationships, population structure, and estimation of the rates of gene flow within this whitefly species remain largely unexplored. In this study, we obtained and filtered 227 GenBank records of mitochondrial cytochrome c oxidase I (mtCOI) sequences of T. vaporariorum, across various global locations to obtain a final set of 217 GenBank records. We further amplified and sequenced a ~750 bp fragment of mtCOI from an additional 31 samples collected from Kenya in 2014. Based on a total of 248 mtCOI sequences, we identified 16 haplotypes, with extensive overlap across all countries. Population structure analysis did not suggest population differentiation. Phylogenetic analysis indicated the 2014 Kenyan collection of samples clustered with a single sequence from the Netherlands to form a well-supported clade (denoted clade 1a) nested within the total set of sequences (denoted clade 1). Pairwise distances between sequences show greater sequence divergence between clades than within clades. In addition, analysis using migrate-n gave evidence for recent gene flow between the two groups. Overall, we find that T. vaporariorum forms a single large group, with evidence of further diversification consisting primarily of Kenyan sequences and one sequence from the Netherlands forming a well-supported clade.
Maize root morphology responses to soil penetration resistance related to tillage and drought in a clayey soil
Authors: HE Y. B. , LIN L. R. , CHEN J. Z. 
Published: May 2017

SUMMARYCrops often experience combined soil stresses. Root responses to soil penetration resistance (PR) and drought stress can be an important basis for crop management. In 2013/14, a 2-year experiment was conducted to evaluate the effect of tillage treatment and drought stress (no irrigation for 4, 12 and 20 days during the V10–V16 growth stage) on the root length, diameter, cortex and cortical cell, and grain yield of maize (Zea mays L.) in a clayey red soil in southern China. Total root length and average root diameter were significantly correlated with soil PR and moisture. The cortical cell file number increased with soil PR and drought stress, while cortical cell size increased only with soil PR. Soil PR and moisture played different roles in maize root morphology modifications, but were both affected by tillage practices. Deep ploughing and conventional tillage increased soil moisture under severe drought stress conditions, whereas soil compaction and no-till significantly increased soil PR. The results indicate that high PR in clayey red soil was responsible for a decrease in maize root size and grain yield under drought conditions.
Opportunities and challenges in metabarcoding approaches for helminth community identification in wild mammals
Authors: AIVELO TUOMAS , MEDLAR ALAN 
Published: May 2017

SUMMARYDespite metabarcoding being widely used to analyse bacterial community composition, its application in parasitological research remains limited. What interest there has been has focused on previously intractable research settings where traditional methods are inappropriate, for example, in longitudinal studies and studies involving endangered species. In settings such as these, non-invasive sampling combined with metabarcoding can provide a fast and accurate assessment of component communities. In this paper we review the use of metabarcoding in the study of helminth communities in wild mammals, outlining the necessary procedures from sample collection to statistical analysis. We highlight the limitations of the metabarcoding approach and speculate on what type of parasitological study would benefit from such methods in the future.
A review of biological and geomorphological processes involved in the initiation and development of incipient foredunes
Authors: Hesp Patrick A. 
Published: May 2017

SynopsisThe evolution, ecological processes, aerodynamics, and morphology of incipient or new foredunes on the upper beach is reviewed. Four types of incipient foredunes may be distinguished, namely: type 1, those initiated by shadow dune formation within zones of discrete individual pioneer annuals (e.g. Cakile spp.), and perennials (e.g. Spinifex spp.; Ammophila spp.); type 2, those initiated by dunelet or hummock formation within discrete colonies of perennial grasses and herbs; type 3, those initiated by sand deposition within laterally extensive colonies of pioneer seedlings; and type 4, those initiated by sand deposition within a laterally extensive plant rhizome cover.Type 1 dunes are dominated by high, local flow deceleration and 3-D flow separation. Shadow dunes form within and downwind of the discrete plants. If colonised by annual plants, invasion by perennial plants is necessary for survival. Later lateral plant spread and accretion produces hummocky terraces and ridges. Type 2 dunes (dunelets) are characterised by local landward flow deceleration and marginal high velocity side flows. Sand deposition results in the formation of low, discrete, semi-circular convex mounds (seedlings), or more elongate hummocks and mounds (rhizomes). Types 3 and 4 dunes are characterised by laterally extensive, often homogeneous vegetation canopies. High canopies display more rapid landward flow deceleration than low canopies, thus narrow, asymmetric ridges and longer convex ridges result respectively. High plant densities result in rapid down-canopy flow deceleration, maximum traction load retardation and the formation of narrow asymmetric ridges. Dune height decreases and dune length increases as plant densities decrease. Maximum deposition zones occur for each wind velocity range. Whether ramp, terrace or ridge morphologies are formed depends on mode of beach colonisation, plant density and distribution, sand volume, wind speed, and plant species type and morphology.A range of variables which affect foredune morphology and evolution, including plant canopy density, height and distribution, wind velocity, and various ecological environmental processes are examined.
Invertebrates of Scottish sand dunes
Authors: Welch R. Colin 
Published: May 2017

SynopsisThe first comparative study in Britain of the invertebrate fauna of a large number of coastal sites was carried out in Scotland in 1976/77. Fifty-eight sites were selected at fifty-four locations in four geographic areas: East Coast, Moray Firth, North & North-west Coast and the Outer Hebrides. Lepidoptera were collected in MV light traps, while Coleoptera, Araneae, Mollusca and Diplopoda were caught in pitfall traps. The results are analysed to show the relationships between the faunal elements of each region and how species distribution correlates with latitude and is affected by climate. Examples are given to illustrate the great range of distribution patterns of selected species in the five major invertebrate groups studied. Some priority areas for site conservation are listed and recommendations made for a different approach to dune management.
On toposes generated by cardinal finite objects
Authors: HENRY SIMON 
Published: May 2017

AbstractWe give a characterisations of toposes which admit a generating set of objects which are internally cardinal finite (i.e. Kuratowski finite and decidable) in terms of “topological” conditions. The central result is that, constructively, a hyperconnected separated locally decidable topos admit a generating set of cardinal finite objects. The main theorem is then a generalisation obtained as an application of this result internally in the localic reflection of an arbitrary topos: a topos is generated by cardinal finite objects if and only if it is separated, locally decidable, and its localic reflection is zero dimensional.
Use of Ambulatory Electrocardiography for the Detection of Paroxysmal Atrial Fibrillation in Patients with Stroke
Authors: Bell Chaim , Kapral Moira ,   The Canadian Task Force on Preventive Health Care
Published: May 2017

ABSTRACT:Background:Patients with stroke commonly undergo investigations to determine the underlying cause of stroke. These investigations often include ambulatory electrocardiography to detect paroxysmal atrial fibrillation. There is conflicting evidence in the literature regarding whether routine ambulatory electrocardiography should be performed in all or selected stroke patients. This paper reviews the available evidence on (1) the yield of ambulatory electrocardiography in detecting paroxysmal atrial fibrillation in patients with stroke or transient ischemic attack and (2) the effectiveness of anticoagulation in preventing recurrent stroke in patients with paroxysmal atrial fibrillation.Methods:A MEDLINE search for primary articles was performed, and the references were reviewed manually. In addition, citations were obtained from experts. The evidence was systematically reviewed using the evidence-based methodology of the Canadian Task Force on Preventive Health Care.Results:Ambulatory electrocardiography can detect atrial fibrillation not found on initial electrocardiogram in between 1% and 5 % of people with stroke. Ambulatory electrocardiography is generally safe. The risk of recurrent stroke in the setting of paroxysmal atrial fibrillation is uncertain, but appears to be similar to that seen with chronic atrial fibrillation (about 12% per year). Therapy with warfarin may reduce this risk by about two-thirds as compared to placebo. The annual risk of major bleeding with warfarin therapy is between 1% and 3% but rates for individual patients depend on various specific risk factors.Interpretation:There is insufficient evidence to recommend for or against the use of ambulatory electrocardiography for the detection of paroxysmal atrial fibrillation in either selected or unselected patients with stroke (C Recommendation). There is fair evidence to recommend therapy with warfarin for patients with stroke and paroxysmal atrial fibrillation (B Recommendation).
Predictors of Poor Outcome in Patients with a Spontaneous Cerebellar Hematoma
Authors: Louis Erik K. , Wijdicks Eelco F. M. , Li Hongzhe , Atkinson John D. 
Published: May 2017

ABSTRACT:Background and purpose:The authors studied the clinical and neuroimaging features of cerebellar hematomas to predict poor outcome using comprehensive statistical models.Methods:We retrospectively reviewed clinical and neuroimaging features in 94 patients with spontaneous cerebellar hematomas to identify predictive features for a poor neurologic outcome, defined as death or dismissal to long-term care facility. Data were analyzed using chi square and Fisher's exact test with calculation of odd's ratios together with 95% confidence intervals.Results:Clinical and neuroradiologic predictors for a poor outcome at p < 0.05 were admission systolic blood pressure > 200 mm Hg, hematoma size >3cm, visible brain stem distortion, and acute hydrocephalus. Presenting findings predicting subsequent death at p < 0.05 were abnormal corneal and oculocephalic responses, Glasgow coma sum score less than 8, motor response less than localization to pain, acute hydrocephalus and intraventricular hemorrhage.Conclusion:A tree-based analysis model using binary recursive partitioning showed that cornea reflex, hydrocephalus, doll's eyes, age, and size were the most important discriminating factors. Absent corneal reflexes on admission highly predicts poor outcome (86 percent, confidence limits 67-96 percent). When a cornea reflex is present, acute hydrocephalus predicts poor outcome but only when doll's eyes are additionally absent.
Generic Substitution for Brand Name Antiepileptic Drugs: A Survey
Authors: Guberman A. , Corman Céline 
Published: May 2017

ABSTRACT:Background/Objective:There are presently 26 different generic preparations for five brand name antiepileptic drugs (AEDs) on the Canadian market with others likely to be released in the near future. The purpose of this review is to examine the basis for the controversy surrounding generic substitution for brand name antiepileptic drugs, to present the results of a survey of neurologists' and patients' attitudes toward generic substitution and to increase neurologists'awareness of the issues.Methods:The current federal and provincial regulations pertaining to generic drug approval and substitution are reviewed. Published anecdotal and survey reports of the effectiveness and tolerability of generic substitution for AEDs are reviewed. A pilot questionnaire survey of 83 patients from four adult epilepsy clinics and 46 neurologists from across Canada was undertaken to determine attitudes toward generic substitution.Results and Conclusions:Several authors have suggested that some AEDs, particularly those with a narrow therapeutic index, may pose problems with generic substitution. Although generic AEDs are lower in price, possible increased side effects and morbidity and the need for closer monitoring could partially offset the cost savings. The results of our survey highlight significant unawareness of the process of generic substitution among both patients and neurologists and reveal a general level of discomfort among neurologists to prescribe generic AEDs. Further data should be obtained about the potential consequences of generic substitution in epilepsy patients.
Craniotomy Revisited: Techniques for Improved Access and Reconstruction
Authors: Cusimano Michael D. , Suhardja Agustinus S. 
Published: May 2017

ABSTRACT:Objective:To describe simple modifications of the technique of opening and closure of the craniotomy to improve basal exposure and reconstruction.Methods:The modifications involve: a) additional soft-tissue dissection which is carried downward to the base of the ear and to the orbital rim, exposing the orbital rim and malar eminence without removing the bone; b) cutting the bone flap so that ‘bridges’ of bone remain that help to stabilize the flap when it is returned to the cranium at the end of the operation; c) the wedging of bone chips between the bone flap and native cranium at the time the bone is being reaffixed so as to provide firm stability by diminishing movement of the bone flap; d) the use of bone dust and bone chips mixed with the patient's blood to seal and bridge the gap between the bone flap and the native bone; e) reattachment of the temporalis muscle with the bone flap sutures. An ‘inlay’ technique of duraplasty is also described.Results and Conclusion:These simple modifications of craniotomy provide better basal exposure and reconstruction with little additional operating time at no additional cost.
Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation
Authors: Pfeffer Peter L. , Smith Craig S. , Maclean Paul , Berg Debra K. 
Published: May 2017

SummaryIn cattle early gastrulation-stage embryos (Stage 5), four tissues can be discerned: (i) the top layer of the embryonic disc consisting of embryonic ectoderm (EmE); (ii) the bottom layer of the disc consisting of mesoderm, endoderm and visceral hypoblast (MEH); (iii) the trophoblast (TB); and (iv) the parietal hypoblast. We performed microsurgery followed by RNA-seq to analyse the transcriptome of these four tissues as well as a developmentally earlier pre-gastrulation embryonic disc. The cattle EmE transcriptome was similar at Stages 4 and 5, characterised by the OCT4/SOX2/NANOG pluripotency network. Expression of genes associated with primordial germ cells suggest their presence in the EmE tissue at these stages. Anterior visceral hypoblast genes were transcribed in the Stage 4 disc, but no longer by Stage 5. The Stage 5 MEH layer was equally similar to mouse embryonic and extraembryonic visceral endoderm. Our data suggest that the first mesoderm to invaginate in cattle embryos is fated to become extraembryonic. TGFβ, FGF, VEGF, PDGFA, IGF2, IHH and WNT signals and receptors were expressed, however the representative members of the FGF families differed from that seen in equivalent tissues of mouse embryos. The TB transcriptome was unique and differed significantly from that of mice. FGF signalling in the TB may be autocrine with both FGFR2 and FGF2 expressed. Our data revealed a range of potential inter-tissue interactions, highlighted significant differences in early development between mice and cattle and yielded insight into the developmental events occurring at the start of gastrulation.
Relationships between blood hormonal concentrations and secondary fibre shedding in young cashmere-bearing goats at their first moult
Authors: Celi P. , Seren E. , Celi R. , Parmeggiani A. , Di Trana A. 
Published: May 2017

AbstractThe aim of this study was to evaluate secondary fibre shedding in relation to seasonal hormonal changes in young cashmere-bearing goats reared in southern Italy. We used 14 cashmere-bearing kids, seven males and seven females, of a Scottish breed-population of goats specialized in cashmere production. Monthly, a hair patch of 4 cm2was clipped from both left and right mid sides alternately and cashmere length and its yield were determined. Blood samples were taken every 2 weeks and plasma was assayed for prolactin (PRL), growth hormone (GH), tri-iodothyronine (T3), thyroxine (T4), progesterone and testosterone. With the same frequency, animals were monitored for onset of moult. Our data indicate that in young cashmere goats at their first moult, secondary fibre shedding is a seasonal event that is strictly related to changes in photoperiod and that PRL has a pivotal rôle in regulating this phenomenon. This corresponds with findings in adults. The observation that both thyroid hormones and sex steroids varied seasonally suggests that they are involved in the regulation of the moult cycle, but their precise rôle remains to be elucidated. Our data also indicate that GH seems to be implicated in the control of the moult cycle. The finding that maximal fibre shedding occurred earlier in males than females could be ascribed to differences in GH levels and to the earlier increase in plasma concentration of PRL observed in males.
Influence of floor type and stocking density on leg weakness, osteochondrosis and claw disorders in slaughter pigs
Authors: Jørgensen B. 
Published: May 2017

AbstractThe effects of floor type and stocking density on leg weakness, osteochondrosis and claw disorders in slaughter pigs were studied. Three hundred pigs were housed in pens with either solid floors with plenty of straw, solid floors without straw or fully slatted floors at either high (0·65 m2per pig) or low (1·2 m2per pig) stocking density from 25 to 105 kg. In each pen half of the pigs were boars and half gilts of the breeds Landrace and Yorkshire ✕ Landrace crossbred. There was no difference in growth rate between the three floor types. The growth rate of the boars was higher at low compared with high stocking density, while no effect of stocking density was seen in the gilts. The prevalence of leg weakness and claw disorders was different for the various floor types, while no effect of floor type could be found on joint changes. With regard to leg weakness, slatted flooring was significantly worse than solid floors with or without straw for standing under position on hind legs, while pens with plenty of straw were significantly better than the other floor types with regard to stiff movement and forelegs turned out. A calculated sum of the nine leg weakness symptoms showed that pens with straw were the best followed by solid floor without straw, while slatted floors were the worst. Regarding claw disorders, solid floors without straw were the worst. High stocking density affected four leg weakness variables (buck-kneed forelegs, turned-out fore- and hind legs, standing under position on hind legs), one joint change and three claw disorders negatively. Boars scored worse than gilts with regard to one leg weakness trait and one claw disorder and thickening of cartilage in two joints. Differences between breeds differed for the examined variables. Claw hardness was affected by floor type with regard to medial claws, which were softer on slatted floors. The hind claws were softer than the foreclaws on the volar surface, while there was no difference between the hardness of the topside of the fore- and hind claws. Claw hardness was not affected by sex. In conclusion, it can be said that the examined floor types do not have the same effect on the different aspects of leg weaknesses and claw disorders. Thus, clinical leg problems are worst on slatted floors and best in pens with straw, but claw disorders are worst on solid floors without straw. Further, high stocking density specifically affects the clinical leg weaknesses and claw disorders. Joint changes were not affected by floor type or stocking density.