bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty acid is a potential agent for bone tissue induction: In vitro and in vivo approach
Authors: Cardoso Guinea BC , Chacon Erivelto , Chacon Priscila GL , Bordeaux-Rego Pedro , Duarte Adriana SS , Saad Sara T Olalla , Zavaglia Cecilia AC , Cunha Marcelo R 
Published: September 2017

Our hypothesis was to investigate the fatty acid potential as a bone induction factor. In vitro and in vivo studies were performed to evaluate this approach. Oleic acid was used in a 0.5 wt.% concentration. Polycaprolactone was used as the polymeric matrix by combining solvent-casting and particulate-leaching techniques, with a final porosity of 70 wt.%, investigated by SEM images. Contact angle measurements were produced to investigate the influence of oleic acid on polycaprolactone chains. Cell culture was performed using adipocyte-derived stem cells to evaluate biocompatibility and bioactivity properties. In addition, in vivo studies were performed to evaluate the induction potential of oleic acid addition. Adipocyte-derived stem cells were used to provide differentiation after 21 days of culture. Likewise, information were obtained with in vivo data and cellular invagination was observed on both scaffolds (polycaprolactone and polycaprolactone /oleic acid); interestingly, the scaffold with oleic acid addition demonstrated that cellular migrations are not related to the surrounding tissue, indicating bioactive potential. Our hypothesis is that fatty acid may be used as a potential induction factor for bone tissue engineering. The study’s findings indicate oleic acid as a possible agent for bone induction, according to data on cell differentiation, proliferation, and migration. Impact statement The biomaterial combined in this study on bone regeneration is innovative and shows promising results in the treatment of bone lesions. Polycaprolactone (PCL) and oleic acid have been studied separately. In this research, we combined biomaterials to assess the stimulus and the speed of bone healing.
Recurrent Graves’ hyperthyroidism after prolonged radioiodine-induced hypothyroidism
Authors: Salman Fariha , Oktaei Hooman , Solomon Solomon , Nyenwe Ebenezer 
Published: September 2017

Background: Radioactive iodine (RAI) is the most cost effective therapy for Graves’ disease (GD). Patients with GD who have become hypothyroid after therapeutic RAI, rarely develop recurrence of disease. Herein we describe a case of recurrence of thyrotoxicosis after 2 years of hypothyroidism. Methods: We present the clinical features, laboratory findings, imaging and management of an unusual case of recurrent hyperthyroidism. Results: A 48-year-old male presented to the emergency room with a 2-day history of palpitation, chest discomfort and 30 pounds of weight loss. Examination was remarkable for rapid and irregular pulse, diffuse thyromegaly and brisk deep tendon reflexes but no eye changes or tremors. Laboratory tests showed thyroid-stimulating hormone (TSH) of <0.004 (0.3–5.6 mIU/ml), free thyroxine (FT4) 4.96 (0.9–1.8 ng/dl), free triiodothyronine (FT3) >20 (1.8–4.7 pg/ml), total thyroxine >800 (80–200 ng/dl). Electrocardiogram showed atrial fibrillation with rapid ventricular response. RAI uptake and scan showed a homogenous gland with 54% uptake in 6 h and 45% in 24 h. He was treated with propranolol and propylthiouracil with some clinical improvement. He subsequently underwent RAI therapy and developed hypothyroidism after 8 weeks. Hypothyroidism was treated with levothyroxine. At 2 years after RAI ablation, he again developed symptoms of hyperthyroidism and had suppressed TSH. The levothyroxine dose was stopped, 3 weeks after discontinuing levothyroxine, he remained hyperthyroid with TSH of 0.008 and FT4 of 1.62 and FT3 of 4.8. RAI uptake demonstrated 17% uptake at 24 h. Conclusion: Recurrent hyperthyroidism in GD is uncommon after development of post-ablative hypothyroidism. Our case illustrates the need for continued surveillance.
Undiagnosed and diagnosed diabetes mellitus among hospitalised acute heart failure patients in Botswana
Authors: Mwita Julius Chacha , Magafu Mgaywa Gilbert Mjungu Damas , Omech Bernard , Tsima Billy , Dewhurst Matthew J , Goepamang Monkgogi , Mashalla Yohana 
Published: September 2017

Objective: The objective of this study was to determine the burden of diagnosed and undiagnosed type 2 diabetes mellitus among patients hospitalised with acute heart failure in Botswana. Methods: The study enrolled 193 consecutive patients admitted with acute heart failure to the medical wards at Princess Marina Hospital in Gaborone. Patients were classified as previously known diabetics, undiagnosed diabetics (glycated haemoglobin ≥ 6.5%) or as non-diabetics (glycated haemoglobin < 6.5%). Data on other comorbid conditions such as hypertension, atrial fibrillation, ischaemic heart disease, stroke, and renal failure were also collected. Results: The mean (SD) age of the participants was 54.2 (17.1) years and 53.9% were men. The percentage of known and undiagnosed diabetes mellitus was 15.5% and 12.4%, respectively. Diabetic patients were significantly more likely to have hypertension (77.8% vs 46.0%, p < 0.001), ischaemic heart disease (20.4% vs 5.0%, p < 0.001), chronic kidney disease (51.3% vs 23.0%, p  < 0.001), and stroke (20.4% vs 5.8%, p  < 0.01). In addition, diabetics were older than non-diabetics (61.0 years vs 51.6 years, p  < 0.001). Conclusion: About 27.9% of patients admitted with acute heart failure in Botswana had diabetes, and almost half of them presented with undiagnosed diabetes. These findings indicate that all hospitalised patients should be screened for diabetes.
Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians
Authors: Stanojevic Sanja , Graham Brian L. , Cooper Brendan G. , Thompson Bruce R. , Carter Kim W. , Francis Richard W. , Hall Graham L. 
Published: September 2017

There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide (T LCO); however, it is not always clear which reference set should be used in clinical practice. The aim of the study was to develop the Global Lung Function Initiative (GLI) all-age reference values forT LCO.Data from 19 centres in 14 countries were collected to defineT LCOreference values. Similar to the GLI spirometry project, reference values were derived using the LMS (lambda, mu, sigma) method and the GAMLSS (generalised additive models for location, scale and shape) programme in R.12 660T LCOmeasurements from asymptomatic, lifetime nonsmokers were submitted; 85% of the submitted data were from Caucasians. All data were uncorrected for haemoglobin concentration. Following adjustments for elevation above sea level, gas concentration and assumptions used for calculating the anatomic dead space volume, there was a high degree of overlap between the datasets. Reference values for Caucasians aged 5–85 years were derived forT LCO, transfer coefficient of the lung for carbon monoxide and alveolar volume.This is the largest collection of normativeT LCOdata, and the first global reference values available forT LCO.
The Newborn Infant Physical Examination: Incorporating the theory into midwifery education
Authors: Jones Tracey , Furber Christine 
Published: September 2017

Background The Newborn Infant Physical Examination (NIPE) can be performed by any qualified health professional, although changes to the roles of health professionals has led to an increase in midwives undertaking continuing professional development (CPD) modules, in order to embrace the NIPE role. Aim The curriculum planning team at the University of Manchester recognised the diverse structures of CPD modules throughout the UK and sought to incorporate the theoretical component of NIPE training into pre-registration midwifery education. Methods The team consulted with local and national stakeholders to assess the need for NIPE education, and the possible challenges. Findings Evaluations from the first cohort of students have been positive, especially in relation to increased employability. Conclusions Including the theory of the NIPE into pre-registration midwifery education has been successful, although support to develop the clinical elements of the NIPE is still needed.
Strategi Advokasi Perempuan Difabel Korban Kekerasan di SAPDA
Authors: Ardiyantika Sulistyary 
Published: September 2017

There two objectives of the current study: First, it is to explain the advocacy strategy used by SAPDA (one prominent Yogyakarta based NGO) for the victims of violence among women with disabilities. Second, barriers they face in doing the advocacy for the women with disabilities. This study identifies three levels of advocacy by SAPDA: micro, mezzo, and macro – modelling them with the typical social work intervensions. The research shows that SAPDA mostly use the mezzo level of advocacy. It is related to the barriers they face in developing advocacy at the other levels. These barriers include the internal barriers such as the human resources; lack of control over advocacy policy; poor planning and management. In addition, there are also what consitute external barriers: management, staffs recruitment, and poor training.[Penelitian ini mempunyai dua tujuan: Pertama, untuk menjelaskan strategi advokasi yang dilakukan SAPDA (Satuan Advokasi Perempuan dan Anak Difabel) terhadap perempuan difabel korban kekerasan. Kedua, menjelaskan hambatan yang dihadapi SAPDA dalam melaksanakan advokasi terhadap perempuan difabel korban kekerasan. Penelitian menunjukkan bahwa strategi advokasi yang dilakukan SAPDA dapat dibedakan menjadi tiga jenis yaitu (1). Mikro, (2). Mezzo dan (3). Makro. Dalam implementasinya, strategi Mezzo merupakan strategi yang paling dominan digunakan oleh SAPDA hingga saat ini. Adapun faktor penghambat terlaksananya advokasi secara internal adalah: (a) Lemahnya sumber daya manusia; (b) Kontrol yang kurang memadai; dan (c) Sistem perencanaan dan pengembangan manajemen yang lemah. Sedangkan kendala dari faktor eksternal meliputi: (a) Manajemen yang belum maksimal, (b) Rekrutmen dan seleksi yang kurang tepat; dan (c) Training yang kurang mengenai pendataan klien.]
Tworzenie kultury jakości: Ustawa 2.0
Authors: Żylicz Maciej 
Published: September 2017

Doskonałości naukowej nie da się zadekretować. Można i trzeba natomiast dążyć do niej poprzez wprowadzenie systemowych projakościowych rozwiązań w finansowaniu nauki oraz wykształcenie w naszym środowisku kultury jakości. Uczelnie badawcze powinny być wyłaniane w otwartym, dwuetapowym konkursie. Kandydujące szkoły wyższe przedstawiałyby swój plan restrukturyzacji organizacyjno-zarządczej oraz koncepcję poprawy jakości prowadzonej przez nie dydaktyki i badań naukowych. Aby poprawić system oceny jakości badań i dydaktyki oraz proces uzyskiwania stopni i tytułu naukowego należy przede wszystkim wprowadzić nową kategoryzację dziedzin naukowych (na wzór ERC). Ocenę parametryczną opartą na punktacji czasopism naukowych trzeba zastąpić oceną opartą na parametrach bardziej odzwierciedlających indywidualny wkład danej publikacji w rozwój odpowiedniej dziedziny/dyscypliny naukowej (mean normalized citation score, MNCS oraz PP, top 10%). Rektor w przyszłym ustroju uczelni powinien mieć silną władzę wykonawczą, ale jego działania powinny być transparentne. Powinien on ponosić odpowiedzialność za podjęte decyzje przed profesjonalnie przygotowanym ciałem, które uczestniczyło w jego powołaniu i które w skrajnych przypadkach może go odwołać. Dla prawidłowej komercjalizacji wyników badań niezbędne jest stworzenie całego „ekosystemu” wspomagającego ten proces (tworzenie wokół uczelni firm typu spin off, sprzedawanie przez centra transferu technologii licencji dotyczących patentów powstałych w uczelniach, zachęty finansowe do współpracy z przemysłem).
O poprawianiu (ale też i o psuciu) systemu przeprowadzania awansów naukowych w Polsce w latach 1990-2017
Authors: Brzeziński Jerzy Marian 
Published: September 2017

Artykuł przedstawia kluczowe problemy polskiego systemu awansów naukowych przeprowadzanych na uczelniach oraz w instytutach PAS i instytutach badawczych. Idzie o nadawanie – przez uprawnione jednostki naukowe – stopni naukowych: doktora i doktora habilitowanego. Autor, po krótkim przedstawieniu tej problematyki w czasach Polski Ludowej (lata 1945-1989) skupia się na ukazaniu ewolucji – i tej pozytywnej i tej złej, psującej ten system – systemu awansów naukowych. Artykuł odwołuje się (w warstwie „dowodowej”) do podstawowych aktów prawnych (ustaw i rozporządzeń) regulujących funkcjonowanie uczelni wyższych oraz – w szczególności – procedury nadawania stopni naukowych. Zdaniem autora w ostatnich kilkunastu latach zaczęły zachodzić w tym obszarze niepokojące zjawiska, które wymagają podjęcia (ale nie pozbawiających autonomii uczelni) działań usprawniających ten ważny system. Aby to uczynić, potrzebny jest konstruktywny dialog obu stron: państwa i uniwersytetu.
Genetic polymorphisms of hemostatic factors and thrombotic risk in non BCR-ABL myeloproliferative neoplasms: A pilot study
Authors: Dambrauskienė R , Gerbutavičius R , Ugenskienė R , Jankauskaitė R , Savukaitytė A , Šimoliūnienė R , Rudžianskienė M , Gerbutavičienė R , Juozaitytė E 
Published: September 2017

Abstract
The most important complications of Philadelphianegagive (non BCR-ABL) myeloproliferative neoplasms (MPNs) are vascular events. Our aim was to evaluate the effects of single nucleotide polymorphisms (SNPs), platelet glycoproteins (GPs) (Ia/IIa, Ibα, IIb/IIIa and VI), von Willebrand factor (vWF), coagulation factor VII (FVII), β-fibrinogen, and the risk of thrombosis in patients with non BCR-ABL MPNs at the Lithuanian University of Health Sciences. Kaunas, Lithuania. Genotyping was done for 108 patients. The TT genotype of the GP Ia/IIa c.807C>T polymorphism was more frequently found in the group of MPN patients with arterial thrombosis compared to MPN patients who were thrombosis-free [26.5 vs. 11.5%, p = 0.049; odds ratio (OR) 2.68; 95% confidence interval (95% CI) 1.01-7.38]. The CT genotype of the β-fibrinogen c.-148C>T polymorphism occurred more frequently in MPN patients with arterial, and total thrombosis compared to the wild or homozygous genotype (57.7 vs. 40.0 vs. 12.5%; p = 0.027), (64.7 vs. 44.4 vs. 25%; p = 0.032), respectively. The carrier state for the c.-323P10 variant of FVII SNP (summation of P10/10 and P0/10) was more frequent in MPN patients with thrombosis compared to the wild-type genotype carriers (71.4 vs. 43.4%; p = 0.049; OR 3.26; 95% CI 1.01-11.31). The coexistence of heterozygous β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP, increased the risk of arterial thrombosis (21.1 vs. 3.7%, p = 0.008; OR 6.93; 95% CI 1.38-34.80). The TT genotype of GP Ia/IIa c.807C>T, the CT genotype of β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP could be associated with risk of thrombosis in MPN patients.
Assessing the Effects of Word Exposure Frequency on Incidental Vocabulary Acquisition from Reading and Listening
Authors: Xiaoning Chen , Feng Teng 
Published: September 2017

AbstractThis study investigated the effects of the frequency at which English as a foreign language (EFL) students were exposed to words from the input modes of reading and listening. Accordingly, 15 words of three frequency groups were selected. A total of 60 Chinese EFL students were recruited. The four test types of recall of form, recognition of form, recall of meaning, and recognition of meaning were administered to measure participants’ ability in building a form-meaning link. Immediate posttests were administered for assessing vocabulary development, and delayed posttests were administered two weeks later for assessing retention. The results revealed that new words could be learned incidentally in both modes, but more word knowledge was gained in reading. The effect of word exposure frequency on incidental vocabulary gains was significant for the four test types in both of the two modes. Since only partial word knowledge was acquired by both modes, it appeared that for the two modes to be a valuable source for incidental vocabulary learning, not only word exposure frequency, but also elaborate word processing is needed. Relevant implications for teaching and learning vocabulary are discussed.
Replication of micro-structured injection molds using physical vapor deposition coating and dynamic laser mold tempering
Authors: Hopmann Christian , Bobzin Kirsten , Brögelmann Tobias , Orth Magnus , Kruppe Nathan , Naderi Mona 
Published: September 2017

AbstractPlastics parts with micro-structured surfaces enable the development of innovative products such as optical components in sensors or light management systems for laser and LED applications. Moreover, micro-structured parts can be utilized in the medical and packaging industry for hydrophobic or antibacterial products. The production of micro-structured parts causes challenges in molding and demolding. Rough surfaces of the laser-structured mold inserts offer flow resistance during injection phase as well as increased demolding forces which cause failures of the replicated structures during ejection. Therefore, an innovative approach combines coated mold inserts by means of physical vapor deposition (PVD) and a highly dynamic laser tempering system to improve the replication of micro-structured plastics parts. Both uncoated and coated micro-structured mold inserts were used in a series of molding experiments by means of conventional and dynamic mold tempering. Based on the results, it can be shown that significant improvements of the replication of micro-structures of different sizes can be achieved by use of PVD mold coatings. This is attributed to the tribological interactions between coating and plastics melt. Furthermore, results indicate an influence of the thermal conductivity of PVD coatings to enhance replication quality.
The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent
Authors: Acharya Kalpana D. , Nettles Sabin A. , Sellers Katherine J. , Im Dana D. , Harling Moriah , Pattanayak Cassandra , Vardar-Ulu Didem , Lichti Cheryl F. , Huang Shixia , Edwards Dean P. , Srivastava Deepak P. , Denner Larry , Tetel Marc J. 
Published: September 2017

AbstractProgestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study, proteins from female mouse hypothalamus that associate with PR were isolated using affinity pull-down assays with glutathione S-transferase–tagged mouse PR-A and PR-B. Using complementary proteomics approaches, reverse phase protein array (RPPA) and mass spectrometry, we identified hypothalamic proteins that interact with PR in a ligand-dependent and isoform-specific manner and were confirmed by Western blot. Synaptic proteins, including synapsin-I and synapsin-II, interacted with agonist-bound PR isoforms, suggesting that both isoforms function in synaptic plasticity. In further support, synaptogyrin-III and synapsin-III associated with PR-A and PR-B, respectively. PR also interacted with kinases, including c-Src, mTOR, and MAPK1, confirming phosphorylation as an integral process in rapid effects of PR in the brain. Consistent with a role in transcriptional regulation, PR associated with transcription factors and coactivators in a ligand-specific and isoform-dependent manner. Interestingly, both PR isoforms associated with a key regulator of energy homeostasis, FoxO1, suggesting a novel role for PR in energy metabolism. Because many identified proteins in this PR interactome are synaptic proteins, we tested the hypothesis that progestins function in synaptic plasticity. Indeed, progesterone enhanced synaptic density, by increasing synapsin-I–positive synapses, in rat primary cortical neuronal cultures. This novel combination of RPPA and mass spectrometry allowed identification of PR action in synaptic remodeling and energy homeostasis and reveals unique roles for progestins in brain function and disease.
'EL CONTADOR ANTE LA TRANSFORMACIÓN SOCIOECONÓMICA DE AMÉRICA LATINA'
Authors: Cova Velásquez Beltrán 
Published: September 2017

Pues bien, les traigo un mensaje de fe, esperanza, optimismo, fraternidad, hermandad, deseo de trabajar en común por el bien de nuestros países en el presente, con un entroncamiento en nuestro pasado común y con visión de futuro. No podría ser de otra forma. Representamos QUINIENTOS (500) MILLONES de seres humanos, desperdigados en una extensa área geográfica, que partiendo de los Pirineos en Europa, se extiende entre los Océanos Atlántico y Pacífico, hasta la tierra del fuego. Un bloque humano caracterizado por: Una unidad lingüística, histórica, religiosa, étnica:	IN ­ DIOS AMERICANOS, IBEROS, ESPAÑOLES Y PORTUGUESES, NEGROS provenientes de varias zonas de África. Nuestros antepasados a los que rendimos nuestro recuerdo y homenaje sincero. En nombre de la CONFEDERACIÓN IBEROAMERI­CANA DE CONTADORES PÚBLICOS SECCIONAL VENEZUELA, realizaré algunas reflexiones acerca del Tema general: "POR UN CONTADOR EFICIENTE COMPROMETIDO CON LA TRANSFORMACIÓN SOCIAL DE AMÉRICA LATINA" y específicamente, sobre "EL CONTADOR ANTE LA TRANSFORMACIÓN SOCIOECONÓMICA DE AMÉRICA LATINA".
EL PROCESO DE CAMBIO ORGANIZATIVO Y LAS ORGANIZACIONES INTELIGENTES
Authors: Talla Ramos Sabino 
Published: September 2017

Actualmente estamos asistiendo a una de las olas de cambio más notables en la historia de la humanidad; ahora, estamos ante un nuevo fenómeno de comunicación que está provocando u na nueva revolución: Internet, que permite emitir y recibir todo tipo de información independientemente de la distancia y a un costo muy bajo; así mismo los planteamientos sobre las organizaciones han ido evolucionando a la par de las cambian tes pe respectivas culturales y socioeconómicas. "El actual es un tiempo de gran agitación empresarial, en el que las instituciones antiguas y formal es se encuentran repentinamente con que tienen que volverse muy flexibles" (Drucker, 1993). Así pues, las organizaciones actuales están sometidas a un proceso de cambio, este ritmo de cambio hace que el nuevo valor de las organizaciones sea la adaptación: adaptarse para sobrevivir. Una de las respuestas a esta situación actual son las "Organizaciones Inteligentes", que plantea soluciones: -	Frente a la variedad: unificación. -	Frente al cambio: capacidad de aprendizaje. -	Frente a la necesidad de conseguir mayor calidad: trabajo en equipo. Las organizaciones hoy en día tienden a ser organizaciones del conocimiento. Las organizaciones que cobrarán relevancia en el futuro serán las que descubran cómo aprovechar el entusiasmo y la capacidad de aprendizaje de la gente en todos los ni veles de la organización, al respecto Arie de Geus advierte que: "La capacidad de aprender puede llegar a ser nuestra única ven taja competitiva".