bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances and gaps in policy, practice, and research in transition for students with intellectual and developmental disabilities across four countries
Authors: Šiška Jan , Beadle‐Brown Julie , Tichá Renáta , Stancliffe Roger , Abery Brian , Káňová Šárka 
Published: September 2024

AbstractThe difficulties faced by youth with intellectual and developmental disabilities (IDDs) and their families as they move into adulthood are widely documented. The aim of the paper is to explore the current situation in terms of transition processes and outcomes in four countries (the US, UK, Australia and Czech Republic) and identify commonalities and differences that help elucidate what might determine different outcomes. Two research methods—expert knowledge and rapid literature review—were combined to identify sources from which information on transition policy, processes, support practices and outcomes was extracted and synthesised. This review identified gaps in the research evidence including inadequate collection and use of data to drive policy and determine effectiveness, limited evidence‐based models or frameworks for successful transition. There was little transition research that included the voices of young people with IDD. More research is necessary to study the practices of highly successful programmes, and to explore the impact of transition programmes and disability support services on a broader range of outcomes, capturing the experiences of young people themselves and identifying factors that determine successful outcomes.
Waitlist and transplant outcomes in patients with metabolic dysfunction‐associated steatotic liver disease and autoimmune hepatitis
Authors: Medina‐Morales Esli , Ismail Mohamed , Goyal Ritik M. , Marenco‐Flores Ana , Saberi Behnam , Fricker Zachary , Bonder Alan , Trivedi Hirsh D. 
Published: September 2024

AbstractBackground and AimsMetabolic dysfunction‐associated steatotic liver disease (MASLD), in the context of autoimmune hepatitis (AIH) among liver transplantation (LT) candidates or recipients remains poorly understood. This study compares waitlist and post‐LT outcomes in patients with MASLD/AIH to MASLD and AIH alone.MethodsUsing the united network organ sharing database (2002–2022), we compared waitlist outcomes and post‐LT survival among patients with MASLD/AIH (n = 282), AIH (n = 5812), and MASLD (n = 33 331). Competing risk, Kaplan Meier estimates and Cox proportional hazard analyses were performed.ResultsMASLD/AIH group had the highest rates of encephalopathy and ascites, and highest MELD scores. MASLD/AIH patients had higher transplantation incidence (adjusted subdistribution hazard ratio [aSHR] 1.64, 95% CI 1.44–1.85; p < .001) and lower waitlist removal risk (aSHR .30, 95% CI .20–.44; p < .001) compared to MASLD alone. One‐year post‐LT survival favoured MASLD compared to AIH (patient: 92% vs. 91%, p < .001; graft: 89% vs. 88%, p < .001) and MASLD/AIH (patient: 92% vs. 90%, p = .008; graft: 89% vs. 88%, p = .023). Recipients with MASLD/AIH showed no significant difference in survival at 10‐year post‐LT compared to MASLD (patient: 63% vs. 61%, p = .68; graft 60% vs. 59%, p = .83) and AIH (patient: 63% vs. 70%, p = .07; graft: 60% vs. 64%, p = .42).ConclusionsOur study showed that MASLD/AIH patients demonstrate higher LT incidence and lower dropout rates. Long‐term post‐LT outcomes did not significantly differ between groups. Further prospective multicenter studies are needed to validate these findings.
A sex chromosome polymorphism maintains divergent plumage phenotypes between extensively hybridizing yellowhammers (Emberiza citrinella) and pine buntings (E. leucocephalos)
Authors: Nikelski Ellen , Rubtsov Alexander S. , Irwin Darren 
Published: September 2024

AbstractUnder allopatric speciation, populations of a species become isolated by a geographic barrier and develop reproductive isolation through genetic differentiation. When populations meet in secondary contact, the strength of evolved reproductive barriers determines the extent of hybridization and whether the populations will continue to diverge or merge together. The yellowhammer (Emberiza citrinella) and pine bunting (E. leucocephalos) are avian sister species that diverged in allopatry on either side of Eurasia during the Pleistocene glaciations. Though they differ greatly in plumage and form distinct genetic clusters in allopatry, these taxa show negligible mitochondrial DNA differentiation and hybridize extensively where they overlap in central Siberia, lending uncertainty to the state of reproductive isolation in the system. To assess the strength of reproductive barriers between taxa, we examined genomic differentiation across the system. We found that extensive admixture has occurred in sympatry, indicating that reproductive barriers between taxa are weak. We also identified a putative Z chromosome inversion region that underlies plumage variation in the system, with the ‘pine bunting’ haplotype showing dominance over the ‘yellowhammer’ haplotype. Our results suggest that yellowhammers and pine buntings are currently at a crossroads and that evolutionary forces may push this system towards either continued differentiation or population merging. However, even if these taxa merge, recombination suppression between putative chromosome Z inversion haplotypes may maintain divergent plumage phenotypes within the system. In this way, our findings highlight the important role hybridization plays in increasing the genetic and phenotypic variation as well as the evolvability of a system.
Autosomal dominant nephrogenic diabetes insipidus in one family caused by a novel AQP2 mutation
Authors: Huang Hou‐Xuan , Sullivan Monika , Zayas Borges Paola , Kennedy Sabina 
Published: September 2024

AbstractA 9‐month‐old male presented with vomiting and dehydration with mild hypernatremia in the context of failure to thrive. He was later diagnosed with nephrogenic diabetes insipidus (NDI) during this hospitalisation and was also found to have eosinophilic esophagitis (EoE). He has since been growing well after EoE and NDI were properly managed. Molecular genetic testing revealed an unreported deletion in AQP2 which was deemed pathogenic and of autosomal dominant inheritance when correlated with his clinical findings and family history. This case report describes the clinical course of this patient in comparison to his family members and reviews current literature on autosomal dominant NDI caused by AQP2 mutations.
Automated visual acuity estimation by optokinetic nystagmus using a stepped sweep stimulus
Authors: Turuwhenua Jason , LinTun Zaw , Norouzifard Mohammad , Edmonds Misty , Findlay Rebecca , Black Joanna , Thompson Benjamin 
Published: September 2024

AbstractPurposeTo describe an automatic system for objective measurement of visual acuity (VA) using optokinetic nystagmus (OKN). This pilot study tested the system's sensitivity and specificity for detecting reduced VA in healthy adults by comparing VA‐OKN to VA with an Early Treatment of Diabetic Retinopathy Study (ETDRS) chart (VA‐ETDRS).MethodsAdult participants (age 30 ± 12 years) with either reduced VA (n = 11, VA‐ETDRS > 0.20 logMAR) or normal VA (n = 12, VA‐ETDRS ≤ 0.20 logMAR) completed monocular VA‐OKN measurements in each eye. The VA‐OKN stimulus was an array of drifting (5°/s) vanishing discs presented in descending/ascending size order (0.00–1.00 logMAR in 0.10 steps). The stimulus was stepped every 2 s, and 10 sweeps were shown per eye (five ascending and five descending). Eye‐tracking data determined when OKN activity ceased (descending sweep) or began (ascending sweep), which was used to determine VA‐OKN for each sweep. The estimates were averaged across sweeps to produce an automated VA‐OKN. The automated sweeps were then provided in randomised order to a reviewer blinded to the VA‐ETDRS findings who determined a final VA‐OKN for an eye.ResultsA single randomly selected eye from each observer was used for analysis. The sensitivity and specificity of VA‐OKN using the same 0.20 logMAR threshold as VA‐ETDRS was 100%. Comparisons between the VA‐OKN and VA‐ETDRS measures were made for participants in the reduced VA group. There was no significant difference between VA‐OKN and VA‐ETDRS (p = 0.55) and the two measures produced comparable values (r2 = 0.84, 95% limits of agreement = 0.19 logMAR, intra‐class correlation coefficient = 0.90 [95% CI:0.68–0.97]).ConclusionsVisual acuity using optokinetic nystagmus correctly identified a VA deficit in adults and for those with a VA deficit, VA‐OKN was strongly correlated with the gold‐standard clinical measure of VA. OKN is a promising method which has the potential for use in cognitively impaired adults and pre‐verbal children.
Deciphering the Role of SVP‐Like Genes and Their Key Regulation Networks During Reproductive Cone Development in Pinus tabuliformis
Authors: Zhou Chengcheng , Liu Hongmei , Wang Huili , Niu Shihui , El‐Kassaby Yousry A. , Li Wei 
Published: September 2024

ABSTRACTReproductive development plays an essential role in the perpetuation of genetic material and environmental adaptation. In angiosperms, the Short Vegetative Phase (SVP) serves as a flowering repressor, influencing the development of floral organs. In this study, heterologous transformation of Arabidopsis thaliana with SVP‐like genes (PtSVL1 and PtSVL2) derived from Pinus tabuliformis significantly impacted stamen formation and pollen fertility, without altering flowering time. Gene co‐expression networks revealed that SVP‐like and SOC1‐like genes function as key coregulatory transcription factors during the initial stages of cone development in P. tabuliformis. Interestingly, the regulatory module of SOC1 regulated by SVP in angiosperms is absent in conifers and conifer SVP‐like exercises its function in a form that is physically bound to SOC1‐like. Furthermore, combining the yeast one‐hybrid scanning with co‐expression network analysis, revealed that SPLs and TPSs were the principal downstream target genes of PtSVL1. Notably, the PtSPL16 promoter is positively regulated by PtSVL1, and overexpression of PtSPL16 results in delayed flowering in Arabidopsis, suggesting that the PtSVL1‐PtSPL16 module plays a crucial role in regulating reproductive development in conifers. Collectively, these findings enhance our understanding of the roles of SVP‐like genes in conifers and the key regulatory networks centred on PtSVL1 during reproductive cone development.
Clinical significance of direct fast scarlet staining on the diagnosis of eosinophilic colitis: A comparative study focusing on the eosinophil degranulation in colonic mucosal tissue
Authors: Ikeda Mina , Kato Hiroyuki , Arakawa Satoshi , Kobayashi Takashi , Hashimoto Senju , Katano Yoshiaki , Inada Ken‐ichi , Kiriyama Yuka , Ishihara Takuma , Yamamoto Satoshi , Asano Yukio , Horiguchi Akihiko 
Published: September 2024

AbstractThis study aimed to validate the DFS (direct fast scarlet) staining in the diagnosis of EC (eosinophilic colitis). The study included 50 patients with EC and 60 with control colons. Among the 60 control samples, 39 and 21 were collected from the ascending and descending colons, respectively. We compared the median number of eosinophils and frequency of eosinophil degranulation by HE (hematoxylin and eosin) and DFS staining between the EC and control groups. In the right hemi‐colon, eosinophil count by HE was useful in distinguishing between EC and control (41.5 vs. 26.0 cells/HPF, p < 0.001), but the ideal cutoff value is 27.5 cells/HPF (high‐power field). However, this method is not useful in the left hemi‐colon (12.5 vs. 13.0 cells/HPF, p = 0.990). The presence of degranulation by DFS allows us to distinguish between the groups even in the left hemi‐colon (58% vs. 5%, p < 0.001). DFS staining also enabled a more accurate determination of degranulation than HE. According to the current standard to diagnose EC (count by HE staining ≥20 cells/HPF), mucosal sampling from left hemi‐colon is problematic since the number of eosinophils could not be increased even in EC. Determination of degranulated eosinophils by DFS may potentiate the diagnostic performance even in such conditions.
Synergistic effects of melatonin and glycine betaine on seed germination, seedling growth, and biochemical attributes of maize under salinity stress
Authors: Su Wennan , Qiu Jiaoqi , Soufan Walid , El Sabagh Ayman 
Published: September 2024

AbstractSalinity stress represents a major threat to crop production by inhibiting seed germination, growth of seedlings, and final yield and, therefore, to the social and economic prosperity of developing countries. Recently, plant growth‐promoting substances have been widely used as a chemical strategy for improving plant resilience towards abiotic stresses. This study aimed to determine whether melatonin (MT) and glycine betaine (GB) alone or in combination could alleviate the salinity‐induced impacts on seed germination and growth of maize seedlings. Increasing NaCl concentration from 100 to 200 mM declined seed germination rate (4.6–37.7%), germination potential (24.5–46.7%), radical length (7.7–40.0%), plumule length (2.2–35.6%), seedling fresh (1.7–41.3%) and dry weight (23.0–56.1%) compared to control (CN) plants. However, MT and GB treatments lessened the adverse effects of 100 and 150 mM NaCl and enhanced germination comparable to control plants. In addition, results from the pot experiments show that 200 mM NaCl stress disrupted the osmotic balance and persuaded oxidative stress, presented by higher electrolyte leakage, hydrogen peroxide, superoxide radicals, and malondialdehyde compared to control plants. However, compared to the NaCl treatment, NaCl+MT+GB treatment decreased the accumulation of malondialdehyde (24.2–42.1%), hydrogen peroxide (36.2–44.0%), and superoxide radicals (20.1–50.9%) by up‐regulating the activity of superoxide dismutase (28.4–51.2%), catalase (82.2–111.5%), ascorbate peroxidase (40.3–59.2%), and peroxidase (62.2–117.9%), and by enhancing osmolytes accumulation, thereby reducing NaCl‐induced oxidative damages. Based on these findings, the application of MT+GB is an efficient chemical strategy for improving seed germination and growth of seedlings by improving the physiological and biochemical attributes of maize under 200 mM NaCl stress.
Introduction and overview on Autogenous Platelet Concentrates
Authors: Quirynen Marc , Sculean Anton , Blanco Juan , Wang Hom‐Lay , Donos Nikos 
Published: September 2024

AbstractThis special issue on autologous platelet concentrates (APCs) provides clinicians with an overview on the current understanding of the use of these biomaterials for soft and hard tissue regeneration. The included papers summarize scientific evidence and the clinical findings, presented in simple tables that outline potential benefits including Patient Reported Outcome Measures (PROMs). This approach enables clinicians to assess clinical relevance and researchers to identify significant gaps in the literature. The first part provides a comprehensive summary of the basic science surrounding APC, with particular focus on their preparation methods. Clear recommendations are outlined, which are crucial for obtaining high‐quality APCs, alongside an exploration of how APCs may influence both soft and hard tissue healing processes. Part 2 delves into the clinical evidence for the potential benefits of APCs across a range of applications: alveolar ridge preservation, sinus floor elevation, periodontal plastic surgery, guided tissue regeneration, guided bone regeneration, the healing of Medication‐Related Osteonecrosis of the Jaw (MRONJ), and endodontic surgery. In the part 3, the discussion turns to the effects of APCs on the healing of extra‐oral wounds, including diabetic foot ulcers, venous leg ulcers, pressure injuries, burns, and more. The fourth section offers a detailed, step‐by‐step flowchart for each treatment modality, providing a clear guide for clinical application.
A Visibility‐Based Multitree of a Space Subdivision for Indoor Localization
Authors: Aleksandrov Mitko , Amoozandeh Kimia , Winter Stephan , Zlatanova Sisi , Tomko Martin 
Published: September 2024

ABSTRACTIn an era where localization is increasingly vital for daily activities, determining an individual's location and providing suggestions is crucial for successful navigation. Central to our method is the concept of visibility areas, defined as spaces from which a landmark is at least partially visible. We tessellate space into a grid and use raycasting to determine these visibility areas. Visibility areas are further subdivided into sub‐spaces, each representing a unique set of visible landmarks. To efficiently manage and query these sub‐spaces, we create a tree of options for each landmark and merge them into one compact multitree. This structure represents a hierarchical composition of sub‐spaces and enhances query efficiency while storing each sub‐space only once in the memory. The multitree is designed to support the rapid identification of sub‐spaces based on observed landmarks, resulting in efficient localization within the environment is presented to calculating the optimal localization point in a visibility area based on suggested visible landmarks. The paper concludes with a discussion of the approach targeting indoor localization but highlights also its potential for further research and some limitations.
Trait association and prediction through integrative k‐mer analysis
Authors: He Cheng , Washburn Jacob D. , Schleif Nathaniel , Hao Yangfan , Kaeppler Heidi , Kaeppler Shawn M. , Zhang Zhiwu , Yang Jinliang , Liu Sanzhen 
Published: September 2024

SUMMARYGenome‐wide association study (GWAS) with single nucleotide polymorphisms (SNPs) has been widely used to explore genetic controls of phenotypic traits. Alternatively, GWAS can use counts of substrings of length k from longer sequencing reads, k‐mers, as genotyping data. Using maize cob and kernel color traits, we demonstrated that k‐mer GWAS can effectively identify associated k‐mers. Co‐expression analysis of kernel color k‐mers and genes directly found k‐mers from known causal genes. Analyzing complex traits of kernel oil and leaf angle resulted in k‐mers from both known and candidate genes. A gene encoding a MADS transcription factor was functionally validated by showing that ectopic expression of the gene led to less upright leaves. Evolution analysis revealed most k‐mers positively correlated with kernel oil were strongly selected against in maize populations, while most k‐mers for upright leaf angle were positively selected. In addition, genomic prediction of kernel oil, leaf angle, and flowering time using k‐mer data resulted in a similarly high prediction accuracy to the standard SNP‐based method. Collectively, we showed k‐mer GWAS is a powerful approach for identifying trait‐associated genetic elements. Further, our results demonstrated the bridging role of k‐mers for data integration and functional gene discovery.
Placemaking in the nuclear sensorium
Authors: Lusztig Irene , Cram Shannon 
Published: September 2024

AbstractThis dialogue considers Irene Lusztig's 2023 film Richland, a place‐based documentary about a nuclear company town in southeastern Washington State. Built by the US government as part of the Manhattan Project, Richland fueled thousands of weapons in the nation's nuclear arsenal, including the bomb dropped on Nagasaki, Japan. Lusztig speaks with interdisciplinary scholar Shannon Cram about how this community inhabits the complex and contradictory relations of atomic violence and nuclear pride. So too, they discuss Lusztig's listening‐centered documentary method with a specific focus on what it means to facilitate listening across political and ideological difference.
Bioreactance noninvasive cardiac output monitoring in euvolemic adult horses subjected with 7.2% saline and 6% hydroxyethyl starch (130/0.4) solution infusions
Authors: Long Alicia E. , Hurcombe Samuel , Hopster Klaus 
Published: September 2024

AbstractObjectiveTo compare the ability of bioreactance noninvasive cardiac output (BR‐NICO) with thermodilution cardiac output (TDCO) for the measurement of cardiac output (CO) in healthy adult horses receiving 2 different IV volume replacement solutions.DesignProspective randomized crossover study from September to November 2021.SettingUniversity teaching hospital.AnimalsSix university‐owned adult horses.InterventionsHorses were randomly assigned to receive 7.2% hypertonic saline solution (HSS) or 6% hydroxyethyl starch (130/0.4) solution (HETA). BR‐NICO and TDCO were measured simultaneously at baseline, 10, 20, 30, 40, 50, 60, 90, and 120 minutes before fluid administration and again at the same times after starting a bolus infusion of IV volume replacers. All solutions were administered within 10 minutes.Measurements and Main ResultsBR‐NICO and TDCO were strongly correlated (Pearson r2 = 0.93; P < 0.01). Regression analysis showed the relationship between TDCO and BR‐NICO was BR‐NICO = 0.48 × TDCO + 0.6. For the corrected BR‐NICO values, the Bland–Altman agreement mean bias and lower/upper limits of agreement were −0.62 and −5.3 to 3.9 L/min, respectively. Lin's concordance (95% confidence interval) between methods was 0.894 (0.825–1.097). Compared with baseline, HSS increased the CO at 10 and 20 minutes (TDCO and BR‐NICO). Compared with baseline, HETA decreased the CO at 10 and 20 minutes (TDCO and BR‐NICO) and increased the CO at 90 (TDCO only) and 120 minutes (TDCO and BR‐NICO).ConclusionsBR‐NICO strongly agreed with TDCO in the measurement of CO in healthy unsedated adult horses. HSS administration significantly increased CO in the first 30 minutes, while HETA initially decreased CO at 10 minutes but increased CO to above baseline values by 90 minutes.
Description of a new genus and species of deep‐sea mysids (Malacostraca, Peracarida, Mysida) from the Caroline Ridge, Northwest Pacific, with a systematic analysis of the order
Authors: Kou Qi , Meland Kenneth , Li Xinzheng 
Published: September 2024

AbstractThe order Mysida Boas, 1883 is a group of small, shrimp‐like peracarid crustaceans with surprisingly high morphological and ecological diversity. In this study, a new genus and species of deep‐sea mysids, Muscamysis carolinensis gen. et sp. n., is described based on a solitary specimen recently collected from the Caroline Ridge, Northwest Pacific. To determine the phylogenetic position of the new genus within Mysida, we reconstruct a comprehensive multi‐gene phylogeny of the order, incorporating 45 species from 10 sub‐families and two families. Our analysis reveals strong support for a close relationship between the new genus and Mysidellinae Czerniavsky, 1882, with both forming a clade nested within Heteromysinae Norman, 1892. Notably, our findings do not support the current delineation or monophyly of most mysid sub‐families, emphasizing the necessity for further taxonomic revisions. Specifically, Palaumysinae Wittmann, 2013 is now synonymized with Erythropinae Hansen, 1910, while Heteromysinae is synonymized with Mysidellinae. Bayesian divergence time estimation uncovers, for the first time, multiple independent coastal subterranean colonizations of mysids during the Mesozoic. Ancestral state reconstruction analyses suggest that characters, such as the cleft telson and reduced male pleopods, are the results of parallel evolution, indicating that certain diagnostic characters may not be apomorphic, thereby necessitating more substantial revisions to the current higher‐level classification of the order.