bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELECTRICAL POTENTIAL AND ELECTRICAL FIELD DISTRIBUTION OF SQUARE ELECTRICAL CAPACITANCE TOMOGRAPHY
Authors: Din Mohammad , Pei Ling Leow , Abdul Rahim Ruzairi , Mohd Razali Nur Adila , Pusppanathan Jaysuman , Pei Song Chee , Azmi Aizat 
Published: December 2015

Electrical Capacitance Tomography (ECT) system helps user to understand the flow distribution inside the close pipe by detecting the variation of permittivity distribution in the inspection area. Generally, most reported ECT systems are implemented to circular shape pipe only. However, square shape pipes are sometimes found in power industry and chemical reactor, therefore this paper is studying the electrical distribution of ECT system within a square pipe. ECT is able to provide fast response, low cost and non-radiation system but similar to all other electrical tomography system, ECT suffers from soft-field effect. This paper proposes segmentation excitation to overcome this problem. Segmentation excitation applies when more than one electrode excited at one time. This paper focuses Protocol 2 or 2-electrode excitation for 8-electrode square ECT system. The simulation was done by using COMSOL Multiphysics. The images of the excitations are presented in this paper. The electrical potential is recorded at the center of the system to analyses the strength of the electrical potential. In addition for square ECT system, the corner configuration provides 3.40% higher electrical potential compared to side excitation configuration.
PROTYPE IMPLEMENTATION OF INFORMATION SERVER FOR SEAMLESS NETWORK HANDOVER OVER IPTV APPLICATION
Authors: R. Mohamed Rajina , Hashim Wahidah , Sameon Sera Syarmila 
Published: December 2015

The use of mobile phone increases exponentially in our daily activities because it is light, mobile and handy that can be used anytime and anywhere. Checking emails, updating our daily status and diary, reading the latest news and online purchasing requires continuous network connection as well as a battery that can last. But sometimes the performance of internet speed is too weak where users are experiencing some problems and eventually leads to network disruption. Hence, users should be given the option to choose the internet connection or internet service provider that offer better service at that time moreover during an emergency. In this paper, we propose a development of Information Server to provide information to consumers about the available network surrounding within a reasonable time upon requested. This method is applied in the user terminal to allow the user freedom to decode on the best network handover.
SOCIAL NETWORK NEWS SENTIMENTS AND STOCK PRICE MOVEMENT: A CORRELATION ANALYSIS
Authors: Sukprasert Anupong , Kanchymalay Kasturi , Salim Naomie , Khan Atif 
Published: December 2015

The stock market prediction is one of the most important issues extensively investigated in the existing academic literatures. Researchers have discovered that real–time news has much bearing on the movement of stock prices. Analysts now have to deal with vast amounts of real time, unstructured streaming data due to the advent of electronic and online news sources. This paper aims to investigate the relationship between online news and actual stock price movement. R programming together with R package are applied to capture and analyze the online news data from Yahoo Financial. The data are plotted into graphs to analyze the relationship between the two variables. In addition, to ensure the levels of the relationship, the Pearson’s correlation and Spearman’s Rank are applied to test whether there is a statistical association between these two variables. This initial analysis of dynamic online news based on sentimental words is relatively constructive.
Microbial community assembly and metabolic function during mammalian corpse decomposition
Authors: Metcalf Jessica L. , Xu Zhenjiang Zech , Weiss Sophie , Lax Simon , Van Treuren Will , Hyde Embriette R. , Song Se Jin , Amir Amnon , Larsen Peter , Sangwan Naseer , Haarmann Daniel , Humphrey Greg C. , Ackermann Gail , Thompson Luke R. , Lauber Christian , Bibat Alexander , Nicholas Catherine , Gebert Matthew J. , Petrosino Joseph F. , Reed Sasha C. , Gilbert Jack A. , Lynne Aaron M. , Bucheli Sibyl R. , Carter David O. , Knight Rob 
Published: December 2015

Decomposition spawns a microbial zooThe death of a large animal represents a food bonanza for microorganisms. Metcalfet al.monitored microbial activity during the decomposition of mouse and human cadavers. Regardless of soil type, season, or species, the microbial succession during decomposition was a predictable measure of time since death. An overlying corpse leaches nutrients that allow soil- and insect-associated fungi and bacteria to grow. These microorganisms are metabolic specialists that convert proteins and lipids into foul-smelling compounds such as cadaverine, putrescine, and ammonia, whose signature may persist in the soil long after a corpse has been removed.Science, this issue p.158
Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort
Authors: Dent Arlene E. , Malhotra Indu , Wang Xuelie , Babineau Denise , Yeo Kee Thai , Anderson Timothy , Kimmel Rhonda J. , Angov Evelina , Lanar David E. , Narum David , Dutta Sheetij , Richards Jack , Beeson James G. , Crabb Brendan S. , Cowman Alan F. , Horii Toshihiro , Muchiri Eric , Mungai Peter L. , King Christopher L. , Kazura James W. 
Published: December 2015

ABSTRACT

IgG antibodies to
Plasmodium falciparum
are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic antibodies to 3 preerythrocytic and 10 blood-stage antigens subsequently increased, reaching peak prevalence by 36 months. In contrast, antibodies measured by VSA, GIA, and IIA remained low even up to 36 months. Infants sensitized to
P. falciparum in utero
, defined by cord blood lymphocyte recall responses to malaria antigens, acquired antimalarial antibodies at the same rate as those who were not sensitized
in utero
, indicating that fetal exposure to malaria antigens did not affect subsequent infant antimalarial responses. Infants with detectable serologic antibodies at 12 months of age had an increased risk of
P. falciparum
infection during the subsequent 24 months. We conclude that serologic measures of antimalarial antibodies in children 36 months of age or younger represent biomarkers of malaria exposure rather than protection and that functional antibodies develop after 36 months of age in this population.
Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination
Authors: Martinez David R. , Permar Sallie R. , Fouda Genevieve G. 
Published: December 2015

ABSTRACTExtensive studies have demonstrated that infant immune responses are distinct from those of adults. Despite these differences, infant immunization can elicit protective immune responses at levels comparable to or, in some cases, higher than adult immune responses to many vaccines. To date, only a few HIV vaccine candidates have been tested in infant populations, and none of them evaluated vaccine efficacy. Recent exciting studies showing that HIV-infected infants can develop broad neutralizing antibody responses and that some HIV vaccine regimens can elicit high levels of potentially protective antibodies in infants provide support for the development and testing of HIV vaccines in pediatric populations. In this review, we discuss the differences in adult and infant immune responses in the setting of HIV infection and vaccination.
The Immunologic Complexity of Growing Up with Malaria—Is Scientific Understanding Coming of Age?
Authors: Laurens Matthew B. 
Published: December 2015

ABSTRACT

In the current issue of
Clinical and Vaccine Immunology
, Mandala et al. report changes in lymphocyte populations in children with uncomplicated malaria, severe malarial anemia, and cerebral malaria compared to controls (W. L. Mandala et al., Clin Vaccine Immunol 23:95–103, 2016,
http://dx.doi.org/10.1128/CVI.00564-15
). This commentary discusses the importance of understanding both helpful and detrimental aspects of the antimalarial immune response that are critical to malaria vaccine development and considers how these responses may relate to antimalarial vaccine safety and efficacy.
Complete Genome Sequences of Hepatitis B Virus from North India Using Ion Torrent
Authors: Prakash Shantanu , Jain Amita , Seth Akanksha , Jain Bhawana 
Published: December 2015

ABSTRACT
Hepatitis B virus (HBV) is among the most common causes of liver cirrhosis. We report the full-genome sequences of seven molecular clones of HBV genotype A, amplified from an HBV-infected North Indian patient. This is probably the first report of the HBV genome sequencing using Ion Torrent from India.
Genome Sequence of a Chromium-Reducing Strain, Bacillus cereus S612
Authors: Wang Dongping , Boukhalfa Hakim , Ware Doug S. , Reimus Paul W. , Daligault Hajnalka E. , Gleasner Cheryl D. , Johnson Shannon L. , Li Po-E 
Published: December 2015

ABSTRACTWe report here the genome sequence of an effective chromium-reducing bacterium,Bacillus cereusstrain S612. The size of the draft genome sequence is approximately 5.4 Mb, with a G+C content of 35%, and it is predicted to contain 5,450 protein-coding genes.
Complete Genome Sequences of an Escherichia coli Laboratory Strain and Trimethoprim-Resistant (TMP32XR) Mutant Strains
Authors: Mohan Abhilash , Bhosle Amrisha , Chandra Nagasuma 
Published: December 2015

ABSTRACT

We report the whole-genome sequences of an
Escherichia coli
laboratory wild-type strain and trimethoprim-resistant strains (two biological replicates, TMP32XR1 and TMP32XR2). Compared to the U00096.3 strain, a widely used strain in laboratory experiments, the laboratory wild-type strain and the drug-resistant strains evolved from this (TMP32XR1 and TMP32XR2) are 13, 24, and 37 bp longer, respectively.
Draft Genome Sequence of Lactobacillus plantarum WLPL04, Isolated from Human Breast Milk
Authors: Tao XueYing , Jiang Meiling , Zhang Feng , Xu Feng , Wei Hua 
Published: December 2015

ABSTRACT

Lactobacillus plantarum
WLPL04, a novel strain, was isolated from a breast milk sample from a healthy woman and demonstrated several probiotic functions. Here, we present the draft genome sequence of this strain, which contains 3,192,587 bp, a G+C content of 44.52%, 3,158 protein-coding genes, and 53 tRNA genes.
The Draft Genome Sequence of
Xanthomonas
sp. Strain Mitacek01 Expands the Pangenome of a Genus of Plant Pathogens
Authors: Couger M. B. , Hanafy Radwa A. , Mitacek Rachel M. , Budd Connie , French Donald P. , Hoff Wouter D. , Elshahed Mostafa S. , Youssef Noha H. 
Published: December 2015

ABSTRACT

We report the draft genome sequence of
Xanthomonas
sp. strain Mitacek01, isolated from an indoor environment vending machine surface with frequent human use in Stillwater, Oklahoma, USA, as part of the Student-Initiated Microbial Discovery project. The genome has a total size of 3,617,426 bp and a contig
N
50
of 1,906,967 bp.
MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol
Authors: Venturini Monica Aida , Zappa Sergio , Minelli Cosetta , Bonardelli Stefano , Lamberti Laura , Bisighini Luca , Zangrandi Marta , Turin Maddalena , Rizzo Francesco , Rizzolo Andrea , Latronico Nicola 
Published: December 2015

IntroductionMagnesium exerts analgaesic effects in several animal pain models, as well as in patients affected by acute postoperative pain and neuropathic chronic pain. There is no evidence that magnesium can modulate pain in patients with peripheral arterial occlusive disease (PAOD). We describe the protocol of a single-centre randomised double-blind clinical trial aimed at assessing the efficacy of oral magnesium supplementation in controlling severe pain in patients with advanced PAOD.Methods and analysisAdult patients affected by PAOD at stages III and IV of Lèriche-Fontaine classification, who are opioid-naïve, and who have been admitted to our Acute Pain Service for intractable pain, will be eligible. Patients will be randomised to the control group, treated with standard therapy (oxycodone and pregabalin) plus placebo for 2 weeks, or to the experimental group (standard therapy plus magnesium oxide). Patients will be evaluated on days 0, 2, 4, 6, 8, 12 and 14; the following information will being collected: daily oxycodone dose; average and maximum pain (Numerical Rating Scale); pain relief (Pain Relief Scale); characteristics of the pain (Neuropathic Pain Scale); impact of pain on the patient's daily activities (Brief Pain Inventory). The primary outcome will be oxycodone dosage needed to achieve satisfactory analgaesia on day 14. Secondary outcomes will be pain relief on day 2, time needed to achieve satisfactory analgaesia and time needed to achieve a pain reduction of 50%. A sample size calculation was performed for the primary outcome, which estimated a required sample size of 150 patients (75 per group).Ethics and disseminationEthical approval of the study protocol has been obtained from Comitato Etico Provinciale di Brescia, Brescia, Italy. Trial results will be disseminated through scientific journal manuscripts and scientific conference presentations.Trial registration numberNCT02455726.
Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer
Authors: Concha-Benavente Fernando , Srivastava Raghvendra M. , Trivedi Sumita , Lei Yu , Chandran Uma , Seethala Raja R. , Freeman Gordon J. , Ferris Robert L. 
Published: December 2015

AbstractMany cancer types, including head and neck cancers (HNC), express programmed death ligand 1 (PD-L1). Interaction between PD-L1 and its receptor, programmed death 1 (PD-1), inhibits the function of activated T cells and results in an immunosuppressive microenvironment, but the stimuli that induce PD-L1 expression are not well characterized. Interferon gamma (IFNγ) and the epidermal growth factor receptor (EGFR) utilize Janus kinase 2 (JAK2) as a common signaling node to transmit tumor cell–mediated extrinsic or intrinsic signals, respectively. In this study, we investigated the mechanism by which these factors upregulate PD-L1 expression in HNC cells in the context of JAK/STAT pathway activation, Th1 inflammation, and HPV status. We found that wild-type, overexpressed EGFR significantly correlated with JAK2 and PD-L1 expression in a large cohort of HNC specimens. Furthermore, PD-L1 expression was induced in an EGFR- and JAK2/STAT1-dependent manner, and specific JAK2 inhibition prevented PD-L1 upregulation in tumor cells and enhanced their immunogenicity. Collectively, our findings suggest a novel role for JAK2/STAT1 in EGFR-mediated immune evasion, and therapies targeting this signaling axis may be beneficial to block PD-L1 upregulation found in a large subset of HNC tumors. Cancer Res; 76(5); 1031–43. ©2015 AACR.
Late Pseudoprogression in Glioblastoma: Diagnostic Value of Dynamic O-(2-[18F]fluoroethyl)-L-Tyrosine PET
Authors: Kebir Sied , Fimmers Rolf , Galldiks Norbert , Schäfer Niklas , Mack Frederic , Schaub Christina , Stuplich Moritz , Niessen Michael , Tzaridis Theophilos , Simon Matthias , Stoffels Gabriele , Langen Karl-Josef , Scheffler Björn , Glas Martin , Herrlinger Ulrich 
Published: December 2015

Abstract
Purpose: Pseudoprogression (PsP) is characterized by therapy-associated but not tumor growth–associated increases of contrast-enhancing glioblastoma lesions on MRI. Although typically occurring during the first 3 months after radiochemotherapy, PsP may occur later in the course of the disease and may then be particularly difficult to distinguish from true tumor progression. We explored PET using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET-PET) to approach the diagnostic dilemma.
Experimental Design: Twenty-six patients with glioblastoma that presented with increasing contrast-enhancing lesions later than 3 months after completion of radiochemotherapy underwent 18F-FET–PET. Maximum and mean tumor/brain ratios (TBRmax and TBRmean) of 18F-FET uptake as well as time-to-peak (TTP) and patterns of the time-activity curves were determined. The final diagnosis of true progression versus late PsP was based on follow-up MRI using RANO criteria.
Results: Late PsP occurred in 7 patients with a median time from radiochemotherapy completion of 24 weeks while the remaining patients showed true tumor progression. TBRmax and TBRmean were significantly higher in patients with true progression than in patients with late PsP (TBRmax 2.4 ± 0.1 vs. 1.5 ± 0.2, P = 0.003; TBRmean 2.1 ± 0.1 vs. 1.5 ± 0.2, P = 0.012) whereas TTP was significantly shorter (mean TTP 25 ± 2 vs. 40 ± 2 min, P &lt; 0.001). ROC analysis yielded an optimal cutoff value of 1.9 for TBRmax to differentiate between true progression and late PsP (sensitivity 84%, specificity 86%, accuracy 85%, P = 0.015).
Conclusions: O-(2-[18F]fluoroethyl)-L-tyrosine PET provides valuable information in assessing the elusive phenomenon of late PsP. Clin Cancer Res; 22(9); 2190–6. ©2015 AACR.
Ankle-Brachial Index and Recurrent Stroke Risk
Authors: Hong Ja Bin , Leonards Christopher O. , Endres Matthias , Siegerink Bob , Liman Thomas G. 
Published: December 2015

Background and Purpose—
The ankle-brachial index (ABI) is a fast, cheap, noninvasive indicator of atherosclerotic burden that may also be a predictor of stroke recurrence. In this systematic review and meta-analysis, we sought to explore ABI’s merit as a marker for stroke recurrence and vascular risk by synthesizing the data currently available in stroke literature.

Methods—
We searched Embase, MEDLINE, and Pubmed databases for prospective cohort studies that included consecutive patients with stroke and transient ischemic attack, measured ABI at baseline, and performed a follow-up assessment at least 12 months after initial stroke or transient ischemic attack. The following end points were chosen for our analysis: recurrent stroke and combined vascular end point (recurrent vascular event or vascular death). Crude risk ratios and adjusted Cox proportional hazard ratios were combined separately using the random-effects model. Study-level characteristics (eg, percent of cohort with a history of hypertension, average cohort age, level of adjustment, and mean follow-up duration) were included as covariates in a metaregression analysis.

Results—
We identified 11 studies (5374 patients) that were not significantly heterogeneous. Pooling adjusted hazard ratios showed that low ABI was associated with both an increased hazard of recurrent stroke (hazard ratio, 1.70; 95% confidence interval, 1.10–2.64) and an increased risk of vascular events or vascular death (hazard ratio, 2.22; 95% confidence interval, 1.67–2.97).

Conclusion—
Our results confirm the positive association between ABI and stroke recurrence. Further studies are needed to see whether inclusion of ABI will help improve the accuracy of prediction models and management of stroke patients.
Enrollment Yield and Reasons for Screen Failure in a Large Prehospital Stroke Trial
Authors: Kim Dae-Hyun , Saver Jeffrey L. , Starkman Sidney , Liebeskind David S. , Ali Latisha K. , Restrepo Lucas , Kim-Tenser May , Valdes-Sueiras Miguel , Eckstein Marc , Pratt Frank , Stratton Samuel , Hamilton Scott , Conwit Robin , Sanossian Nerses 
Published: December 2015

Background and Purpose—
The enrollment yield and reasons for screen failure in prehospital stroke trials have not been well delineated.

Methods—
The Field Administration of Stroke Therapy–Magnesium (FAST-MAG) trial identified patients for enrollment using a 2 stage screening process—paramedics in person followed by physician-investigators by cell phone. Outcomes of consecutive screening calls from paramedics to enrolling physician-investigators were prospectively recorded.

Results—
From 2005 to 2012, 4458 phone calls were made by paramedics to physician-investigators, an average of 1 call per vehicle every 135.7 days. A total of 1700 (38.1%) calls resulted in enrollments. The rate of enrollment of stroke mimics was 3.9%. Among the 2758 patients not enrolled, 3140 reasons for screen failure were documented. The most common reasons for nonenrollment were >2 hours from last known well (17.2%), having a prestroke condition causing disability (16.1%), and absence of a consent provider (9.5%). Novel barriers for phone informed consent specific to the prehospital setting were infrequent, but included: cell phone connection difficulties (3.2%), patient being hard of hearing (1.4%), insufficient time to complete consent (1.3%), or severely dysarthric (1.3%).

Conclusions—
In this large, multicenter prehospital trial, nearly 40% of every calls from the field to physician-investigators resulted in trial enrollments. The most common reasons for nonenrollment were out of window last known well time, prestroke confounding medical condition, and absence of a consent provider.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00059332.
Genome sequences of two closely related strains of Escherichia coli K-12 GM4792
Authors: Zhang Yan-Cong , Zhang Yan , Zhu Bi-Ru , Zhang Bo-Wen , Ni Chuan , Zhang Da-Yong , Huang Ying , Pang Erli , Lin Kui 
Published: December 2015

AbstractEscherichia coli lab strains K-12 GM4792 Lac+ and GM4792 Lac- carry opposite lactose markers, which are useful for distinguishing evolved lines as they produce different colored colonies. The two closely related strains are chosen as ancestors for our ongoing studies of experimental evolution. Here, we describe the genome sequences, annotation, and features of GM4792 Lac+ and GM4792 Lac-. GM4792 Lac+ has a 4,622,342-bp long chromosome with 4,061 protein-coding genes and 83 RNA genes. Similarly, the genome of GM4792 Lac- consists of a 4,621,656-bp chromosome containing 4,043 protein-coding genes and 74 RNA genes. Genome comparison analysis reveals that the differences between GM4792 Lac+ and GM4792 Lac- are minimal and limited to only the targeted lac region. Moreover, a previous study on competitive experimentation indicates the two strains are identical or nearly identical in survivability except for lactose utilization in a nitrogen-limited environment. Therefore, at both a genetic and a phenotypic level, GM4792 Lac+ and GM4792 Lac-, with opposite neutral markers, are ideal systems for future experimental evolution studies.
Complete genome sequence of the molybdenum-resistant bacterium Bacillus subtilis strain LM 4–2
Authors: You Xiao-Yan , Wang Hui , Ren Guang-Yue , Li Jing-Jing , Duan Xu , Zheng Hua-Jun , Jiang Zheng-Qiang 
Published: December 2015

AbstractBacillus subtilis LM 4–2, a Gram-positive bacterium was isolated from a molybdenum mine in Luoyang city. Due to its strong resistance to molybdate and potential utilization in bioremediation of molybdate-polluted area, we describe the features of this organism, as well as its complete genome sequence and annotation. The genome was composed of a circular 4,069,266 bp chromosome with average GC content of 43.83 %, which included 4149 predicted ORFs and 116 RNA genes. Additionally, 687 transporter-coding and 116 redox protein-coding genes were identified in the strain LM 4–2 genome.