bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two converging paths: behavioural sciences and social marketing for better policies
Authors: Dessart François J. , van Bavel René 
Published: October 2017

PurposeThis commentary argues that social marketing and the application of behavioural sciences to policy constitute two converging paths towards better policies. It highlights points of convergence and divergence between both disciplines and the potential benefits of further embedding social marketing principles and methods within the recent trend of applying behavioural sciences to policy.Design/methodology/approachThe commentary relies on a review of the behavioural sciences and social marketing literatures and on an analysis of institutional reports reviewing cases of behaviourally informed policies.FindingsBehavioural sciences are increasingly informing policies to promote societal well-being. Social marketing has seldom been explicitly considered as being part of this phenomenon, although it isde facto. Both disciplines share similar end-goals, inform similar policy applications and are rooted in behavioural analysis. They diverge in their theoretical frameworks, their relative emphasis on behaviour change and the span of interventions they generate. Several benefits of embedding social marketing principles and methods within the current way of applying behavioural sciences to policy are identified.Practical implicationsScholars applying behavioural sciences to policy are encouraged, when appropriate, to use the insights and methods from social marketing. Social marketing can engage in a dialogue with behavioural sciences to explore how to pilot the convergence of both approaches in practice.Originality/valueThe novelty of this contribution lies in providing the first comparison of the application of behavioural sciences to policy with social marketing, and in using the policy-making cycle framework to map the contributions and complementarities of both disciplines.
Value capturing in Floorball
Authors: Gabrielsson Carl , Dolles Harald 
Published: October 2017

Purpose
Floorball is a Swedish sports innovation which emerged and started to be played about 40 years ago. The purpose of this paper is to explore value capturing in this relatively new sport and the various contributions made by different actors towards market development of the sport.

Design/methodology/approach
The research utilizes a theoretical framework of value capturing in professional team sports for research. The analysis is based upon 13 semi-structured interviews with representatives from three groups, “players/coaches,” “board members and “manufacturers/retailers.”

Findings
All economic actors within the research framework contribute to various extents to the market development of the sport, yet they all need to cooperate, exemplifying that innovation for market development and value for the sport can only be co-created.

Research limitations/implications
The sample is taken from the Swedish market and may, thus, be considered biased.

Practical implications
All economic actors within the research framework contribute to market development of the sport to various degrees, yet they all need to cooperate, exemplifying that innovation for market development and value for the sport can only be co-created.

Originality/value
This paper provides unique insights into the development of floorball as a “new” sport.
Re-conceptualizing reverse meaning transfer: the moderating influence of meaning type
Authors: Baker III Thomas A. , Byon Kevin K. , Brison Natasha T. 
Published: October 2017

Purpose
The purpose of this paper is to determine whether negative meanings consumers attribute to a corporation transfer to the endorser and to examine the moderating effects of corporate-specific and product-specific negative meanings on an endorser’s credibility.

Design/methodology/approach
Following a protocol designed by Till and Shimp (1998), two experiments were conducted to examine if meaning transfer exists (experiment 1) and if meaning type moderates reverse meaning transfer (experiment 2). A doubly repeated multivariate analysis of variance was conducted to investigate changes in the endorser’s credibility and attitudes toward the brand.

Findings
The results revealed that the negative meanings consumers associated with these corporate crises influence consumer perceptions of the endorser as well as attitude toward the brand.

Research limitations/implications
This finding supports the position that meaning type moderates reverse meaning transfer and may explain variances in the literature on the significance of reverse meaning transfer. Based on these findings, brand crises have a negative effect on the endorser’s credibility.

Practical implications
The results lead the authors to suggest that endorsers as well as marketers should closely scrutinize brand partnerships, as the relationship may positively and negatively influence consumer perceptions of the athlete endorser.

Social implications
Based on the findings from this study, brand managers need to appreciate differences in brand crisis type by tailoring brand image remediation strategies to fit the type(s) of meaning(s) associated with a specific controversy.

Originality/value
The results from the current study add, significantly, to the literature by being the first to evidence that different meanings associated with different types of brand crises produce different attitudes toward the brand.
Prorenin receptor mediates inflammation in renal ischemia
Authors: Quadri Syed S , Culver Silas , Siragy Helmy M 
Published: October 2017

SummaryWe hypothesized that PRR contributes to renal inflammation in the 2‐kidney, 1‐clip (2K1C) renal ischaemia model. Male Sprague‐Dawley rats were fed normal sodium diet. Blood pressure (BP) was obtained on days 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%. Renal expression of TNF‐α, COX‐2, NF‐κB, IL‐1β, MCP‐1 and collagen type I were assessed in sham and 2K1C rats with or without left renal administration of scramble or PRR shRNA. At baseline, there were no differences in BP. Compared to sham, MAP significantly increased in clipped animals (sham 102 ± 1.9 vs 2K1C 131.8 ± 3.09 mmHg, P < .05) and was not influenced by scramble or PRR shRNA treatment. Compared to sham and contra lateral (non‐clipped) kidney, there was upregulation in mRNA and protein expression of PRR (99% and 45%, P < .01), TNF‐α (72% and 50%, P < .05), COX‐2 (72% and 39%, P < .05), p‐NF‐κB (92%, P < .05), MCP‐1 (87%, P < .05) and immunostaining of collagen type I in the clipped kidney. These increases were not influenced by scramble shRNA. Compared to 2K1C and scramble shRNA, PRR shRNA treatment in the clipped kidney significantly reduced the expression of PRR (62% and 57%, P < .01), TNF‐α (51% and 50%, P < .05), COX‐2 (50% and 56%, P < .05), p‐NF‐κB by 68% (P < .05), MCP‐1 by 73% (P < .05) and collagen type I respectively. Ang II was increased in both kidneys and did not change in response to scramble or PRR shRNA treatments. We conclude that PRR mediates renal inflammation in renal ischaemia independent of blood pressure and Ang II.
The use of Singapore flaps for vaginal reconstruction in women with vaginal stenosis with obstetric fistula: a surgical technique
Authors: Pope RJ , Brown RH , Chipungu E , Hollier LH , Wilkinson JP 
Published: October 2017

Gynecologic and plastic surgeons collaborate to improve vaginal reconstruction for women with vaginal stenosis and obstetric fistula. As these cases occur typically in low‐resource settings, the Singapore flap is a useful technique given its reliability, safety, ease of dissection, and minimal need for additional supplies. The fasciocutaneous flap maintains cutaneous innervation and vasculature and does not require stenting. The surgical collaboration has made it possible to provide functional vaginal reconstruction as a part of the overall care of obstetric fistula patients. The technique shows promise for improving sexual function for women with obstetric fistula and may also enhance healing.Tweetable abstractGynecologic & plastic surgeons collaborate to improve vaginal reconstruction for women with obstetric fistula.
TOWARD A BIFURCATED THEORY OF EMOTIONAL DETERRENCE
Authors: PICKETT JUSTIN T. , ROCHE SEAN PATRICK , POGARSKY GREG 
Published: October 2017

AbstractSince Hobbes (1957 [1651] and Beccaria (1963 [1764]), scholars have theorized that the emotion of fear is critical for deterrence. Nevertheless, contemporary deterrence researchers have mostly overlooked the distinction between perceived sanction risk and fear of apprehension. Whereas perceived risk is a cognitive judgment, fear involves visceral feelings of anxiety or dread. Equally important, a theory explicating the influence of deterrence on both criminal propensity and situational offending has remained elusive. We develop a theoretical model in which perceived risk and fear are distinguished at both the general and situational levels. We test this theoretical model with data from a set of survey‐based experiments conducted in 2016 with a nationwide sample of adults (N = 965). We find that perceived risk and fear are empirically distinct and that perceived risk is positively related to fear at both the general and situational levels. Certain background and situational factors have indirect effects through perceived risk on fear. In turn, perceived risk has indirect effects through fear on both criminal propensity and situational intentions to offend. Fear's inclusion increases explanatory power for both criminal propensity and situational offending intentions. Fear is a stronger predictor than either self‐control or prior offending of situational intentions to offend.
Fostering a culture of research within a clinical radiation oncology department
Authors: Hanlon Mary‐Claire , Ludbrook Joanna , Jovanovic Karen , Greer Peter , Martin Jarad Marcus 
Published: October 2017

AbstractIntroductionSupport and investment in increasing a research‐active culture in clinical practice needs to be translated at the department and hospital levels as well as regional, state and national levels. We aimed to improve the research culture of our department, to enable more clinical staff to become more research competent and research active.MethodsWe describe and discuss the appointment of a Director of Research and a Research Coordinator into our already‐research‐active department and the interactions at the research–clinical interface. By identifying barriers and instituting enablers which ameliorate their effect, we explore how a clinical department can utilize the resources already available with the goal of developing a more confident and competent clinician‐researcher culture as measured by a range of research metrics.ResultsWe observed an improved research culture within our department. Our department's improved research culture was reflected by increased numbers of peer‐reviewed publications (of 30%), research students/supervisions (of 60%) and engagement of external speakers. We also observed double the number of first‐authored peer‐reviewed articles and a growth in conference presentations, posters and speaker invitations/awards. In the majority of the research performance metrics tracked, there was a steady improvement noted over the four years monitored.ConclusionsBy responding to the barriers of staff (such as time, expertise and ideas) with structural and personal enablers, as well as funded resources, it is possible to develop research capacity and confidence in a clinical setting.
Utilizing 18F‐fluoroethyl‐l‐tyrosine positron emission tomography in high grade glioma for radiation treatment planning in patients with contraindications to MRI
Authors: Jaymanne Dasantha T , Kaushal Sneha , Chan David , Schembri Geoff , Brazier David , Bailey Dale , Wheeler Helen , Back Michael 
Published: October 2017

AbstractIntroductionPatients with high grade glioma (HGG) and contraindications to magnetic resonance imaging (MRI) are dependent on contrast‐enhanced computerized tomography (CT) scan imaging for radiation therapy (RT) target volume delineation. This study reviews the experience with the utilization of 18F‐fluoroethyl‐l‐tyrosine positron emission tomography (FET‐PET) to define residual disease post craniotomy and optimize RT planning.MethodsPatients with HGG and a contraindication to MRI managed with radiation therapy between 2007 and 2015 were identified. RT target volumes including gross tumour volume (GTV) defined by CT‐alone and the biological target volume (BTV) defined by PET‐CT were recorded. Clinical target volumes (CTV) were created from the GTV and BTV respectively using standard protocol volume expansion. The expanded BTV was termed clinical target volume biological (CTV‐B). Union and intersection between CTV and CTV‐B, conformity index, volumetric parameters and individual patient outcomes were analysed.ResultsSix patients fit study criteria. There was a mean increase in CTV‐B from CTV by 31.6% with a conformity index of 0.78. Two out of six patients had FET‐PET avid disease outside the constructed PTV when delineated by CT‐alone. One patient with CT‐only planning had a new contrast‐enhancing mass within 1 month of completing RT, suggesting potential geographical miss.ConclusionPatients with contraindication to MRI the addition of FET‐PET can improve target volume delineation for RT Planning.
Contributors to the substantial variation in on‐treatment testosterone levels in men receiving transdermal testosterone gels in randomized trials
Authors: Bhasin S. , Travison T. G. , O'Brien L. , MacKrell J. , Krishnan V. , Ouyang H. , Pencina K. , Basaria S. 
Published: October 2017

SummaryThere is substantial inter‐individual variability in serum testosterone levels in hypogonadal men treated with testosterone gels. We aimed to elucidate participant‐level factors that contribute to inter‐individual variability in testosterone levels during testosterone therapy. An exploratory aim was to determine whether polymorphisms in genes encoding testosterone‐metabolizing enzymes could explain the variation in on‐treatment testosterone concentrations in men who were randomized to testosterone arm in TOM Trial. We used data from three randomized trials that used 1% transdermal testosterone gels and had testosterone levels measured 2–4 weeks after randomization for dose adjustment: Testosterone in Older Men with Mobility Limitation (TOM), Effects of Testosterone on Pain Perception (TAP), and Effects of Testosterone on Atherosclerosis Progression (TEAAM). Forty‐seven percent, 38%, and 9% of participants in TAP, TEAAM, and TOM trials, respectively, failed to raise testosterone levels >400 ng/dL; 6, 8, and 30% of participants had on‐treatment testosterone levels >1000 ng/dL. Even after dose adjustment, there was substantial variation in on‐treatment levels at subsequent study visits. Baseline characteristics (age, height, weight, baseline testosterone, SHBG, hematocrit, and creatinine) accounted for only a small fraction of the variance (<8%). Polymorphisms in SHBG and AKR1C3 genes were suggestively associated with on‐treatment testosterone levels. To conclude, baseline participant characteristics account for only a small fraction of the variance in on‐treatment testosterone levels investigated. Multiple dose titrations are needed to maintain on‐treatment testosterone levels in the target range. The role of SHBG and AKR3C1 polymorphisms as contributors to variations in on‐treatment testosterone levels should be investigated.
Pancreatoduodenectomy in a public versus private teaching hospital is comparable with some minor variations
Authors: Chua Terence C. , Mittal Anubhav , Nahm Chris , Hugh Thomas J. , Arena Jenny , Gill Anthony J. , Samra Jaswinder S. 
Published: October 2017

BackgroundThe impact of the public and private hospital systems on major abdominal operations that are demanding on clinical resources, such as pancreatic surgery, has not been explored in an Australian setting. This study examines the perioperative outcome of patients undergoing pancreatoduodenectomy (PD) at a major public and private hospital.MethodsPatients undergoing PD between January 2004 and October 2015 were classified based on their health insurance status and location of where the surgery was performed. Clinical variables relating to perioperative outcome were retrieved and compared using univariate and multivariate analyses.ResultsFour hundred and twenty patients underwent PD of whom 232 patients (55%) were operated on in the private hospital. Overall, there was no difference in morbidity and mortality in the public versus the private hospital. However, there were variations in public versus private hospital, this included longer duration of surgery (443 min versus 372 min; P < 0.001), increased estimated blood loss (683 mL versus 506 mL; P < 0.001) and more patients requiring perioperative blood transfusion (25% versus 13%; P = 0.001). Of the 10 complications compared, post‐operative bleeding was higher in the private hospital (11% versus 5%; P = 0.051) and intra‐abdominal collections were more common in the public hospital (11% versus 5%; P = 0.028). Independent predictive factors for major complications were American Society of Anesthesiologists score (odds ratio (OR) = 1.91; P = 0.050), patients requiring additional visceral resection (OR = 3.36; P = 0.014) and post‐operative transfusion (OR = 3.37; P < 0.001). The hospital type (public/private) was not associated with perioperative outcome.ConclusionComparable perioperative outcomes were observed between patients undergoing PD in a high‐volume specialized unit in both the public and private hospital systems.
Diffuse gliomas with FGFR3‐TACC3 fusion have characteristic histopathological and molecular features
Authors: Bielle Franck , Di Stefano Anna‐Luisa , Meyronet David , Picca Alberto , Villa Chiara , Bernier Michèle , Schmitt Yohann , Giry Marine , Rousseau Audrey , Figarella‐Branger Dominique , Maurage Claude‐Alain , Uro‐Coste Emmanuelle , Lasorella Anna , Iavarone Antonio , Sanson Marc , Mokhtari Karima 
Published: October 2017

AbstractAdult glioblastomas, IDH‐wildtype represent a heterogeneous group of diseases. They are resistant to conventional treatment by concomitant radiochemotherapy and carry a dismal prognosis. The discovery of oncogenic gene fusions in these tumors has led to prospective targeted treatments, but identification of these rare alterations in practice is challenging. Here, we report a series of 30 adult diffuse gliomas with an in frame FGFR3‐TACC3 oncogenic fusion (n = 27 WHO grade IV and n = 3 WHO grade II) as well as their histological and molecular features. We observed recurrent morphological features (monomorphous ovoid nuclei, nuclear palisading and thin parallel cytoplasmic processes, endocrinoid network of thin capillaries) associated with frequent microcalcifications and desmoplasia. We report a constant immunoreactivity for FGFR3, which is a valuable method for screening for the FGFR3‐TACC3 fusion with 100% sensitivity and 92% specificity. We confirmed the associated molecular features (typical genetic alterations of glioblastoma, except the absence of EGFR amplification, and an increased frequency of CDK4 and MDM2 amplifications). FGFR3 immunopositivity is a valuable tool to identify gliomas that are likely to harbor the FGFR3‐TACC3 fusion for inclusion in targeted therapeutic trials.
Sweet's syndrome: diagnostic criteria revisited
Authors: Nofal Ahmad , Abdelmaksoud Ayman , Amer Hala , Nofal Eman , Yosef Ayman , Gharib Khaled , Albalat Waleed , Eldesouky Fatma , Ebrahim Howyda M. , Abdelshafy Ahmed Said , Fayed Hala 
Published: October 2017

SummaryThe diagnosis of Sweet's syndrome (SS) is based on a set of criteria that requires the presence of two major and at least two minor criteria. In some cases, however, the diagnosis is not as straightforward due to the absence of certain criteria. The objective of the present study was to review the clinical, histopathological, and laboratory features of the current diagnostic criteria for SS, and to evaluate their validity in the cases reported in the literature as well as in 40 patients treated at our institution. Our comprehensive review of the current criteria for SS reveals that the two major criteria have been consistently present in all cases – including ours – since the first description of SS in 1964. With regard to the minor criteria, on the other hand, there has been marked variability between different studies, and many cases failed to fulfill the requirement of showing two minor criteria. In order to simplify the diagnosis, avoid misdiagnosis, and allow for prompt treatment, we propose two sets of revised diagnostic criteria for SS. The first set comprises constant clinical and histopathological features that must be present and are by themselves sufficient for the diagnosis of SS to be established. The second set includes variable features whose absence does not warrant ruling out SS.
Comparison of two blood sampling techniques for the determination of coagulation parameters in the horse: Jugular venipuncture and indwelling intravenous catheter
Authors: Mackenzie C. J. , McGowan C. M. , Pinchbeck G. , Carslake H. B. 
Published: October 2017

SummaryBackgroundEvaluation of coagulation status is an important component of critical care. Ongoing monitoring of coagulation status in hospitalised horses has previously been via serial venipuncture due to concerns that sampling directly from the intravenous catheter (IVC) may alter the accuracy of the results. Adverse effects such as patient anxiety and trauma to the sampled vessel could be avoided by the use of an indwellingIVCfor repeat blood sampling.ObjectivesTo compare coagulation parameters from blood obtained by jugular venipuncture withIVCsampling in critically ill horses.Study designProspective observational study.MethodsA single set of paired blood samples were obtained from horses (n = 55) admitted to an intensive care unit by direct jugular venipuncture and, following removal of a presample, via an indwellingIVC. The following coagulation parameters were measured on venipuncture andIVCsamples: whole blood prothrombin time (PT), fresh plasmaPTand activated partial thromboplastin time (aPTT) and stored plasma antithrombin activity (AT) and fibrinogen concentration. D‐dimer concentration was also measured in some horses (n = 22). Comparison of venipuncture andIVCresults was performed using Lin's concordance correlation coefficient. Agreement between paired results was assessed using Bland Altman analysis.ResultsCorrelation was substantial and agreement was good between sample methods for all parameters exceptATand D‐dimers.Main limitationsEach coagulation parameter was tested using only one assay. Sampling was limited to a convenience sample and timing of sample collection was not standardised in relation to when the catheter was flushed with heparinised saline.ConclusionsWith the exception ofATand D‐dimers, coagulation parameters measured on blood samples obtained via anIVChave clinically equivalent values to those obtained by jugular venipuncture.