bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra–low‐dose radiotherapy for definitive management of ocular adnexal B‐cell lymphoma
Authors: Pinnix Chelsea C. , Dabaja Bouthaina S. , Milgrom Sarah A. , Smith Grace L. , Abou Zeinab , Nastoupil Loretta , Romaguera Jorge , Turturro Francesco , Fowler Nathan , Fayad Luis , Westin Jason , Neelapu Sattva , Fanale Michelle A. , Rodriguez Maria A. , Hagemeister Frederick , Lee Hun Ju , Oki Yasuhiro , Wang Michael , Samaniego Felipe , Chi Linda , Esmaeli Bita 
Published: April 2017

ABSTRACTBackgroundThe purpose of this study was to report the response to and toxicity of ultra–low‐dose radiotherapy (RT) for B‐cell ocular adnexal lymphoma (OAL).MethodsWe conducted a retrospective review of patients with indolent B‐cell and mantle cell OAL treated with 4 Gy to the orbit(s) in two 2‐Gy fractions. Disease response was assessed clinically and/or radiographically at 2 to 4‐month intervals after RT. Data collected included rates of overall response, complete response (CR), partial response (PR), and treatment‐related toxic effects.ResultsTwenty‐two patients (median age, 65 years) had the following histologic subtypes: mucosa‐associated lymphoid tissue (MALT; 14 patients; 64%); follicular lymphoma (5 patients; 23%); mantle cell lymphoma (MCL; 2 patients; 9%); and unclassifiable (1 patient, 4%). The overall response rate was 100%; 19 patients (86%) had a CR and 3 patients (14%) had a PR. The only acute toxic effect was grade 1 dry eye syndrome in 1 patient.ConclusionUltra–low‐dose RT in patients with OAL is associated with high response rates and minimal toxic effects, and is much shorter in duration and cost. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1095–1100, 2017
Reviewing the genetic alterations in high‐risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets
Authors: Ashford Bruce G. , Clark Jonathan , Gupta Ruta , Iyer N. Gopalakrishna , Yu Bing , Ranson Marie 
Published: April 2017

AbstractCutaneous squamous cell carcinoma (SCC) is second only in incidence to basal cell carcinoma (BCC), effecting up to 500 000 people in the United States annually. Metastasis to regional lymph nodes occurs in approximately 5% of cases and imparts significant morbidity. Standard treatment in this group involves a combination of surgery and adjuvant radiation. Currently, there are no clinically useful biomarkers of metastatic potential in primary cutaneous SCC and histological predictors can be unreliable. The high level of mutational burden in normal UV‐exposed skin has hampered the search for novel drivers of invasive disease, and indeed metastatic potential. This review outlines the clinical problems in high‐risk and metastatic cutaneous SCCs, reviews the known genetic events and molecular mechanisms in high‐risk primary cutaneous SCC and metastasis, and identifies avenues for further investigation and potential therapy.
Minimally invasive wire‐guided balloon catheter puncture for voice prosthesis insertion
Authors: Tobed Secall Marc , Bores Toni , Sambola Ignacio , Lop Joan , García Rica Eduardo , Lluansi Jordi 
Published: April 2017

AbstractBackgroundTracheoesophageal puncture is an effective and reliable method for voice restoration after total laryngectomy that may be performed as a primary or secondary procedure.MethodsWe describe our technique for secondary tracheoesophageal puncture using a wire‐guided balloon catheter in an office setting. A 72‐year‐old patient with a total laryngectomy performed 2 years ago was selected for wire‐guided balloon catheter puncture and voice prosthesis insertion.ResultsSuccessful tracheoesophageal puncture placement was achieved without complications and the patient tolerated the procedure well. The voice result was satisfactory and immediate.ConclusionWe conclude that balloon catheter tracheoesophageal puncture can be a simple and safe option for secondary voice prosthesis insertion in total laryngectomy for selected patients. It can be performed in an office setting using only local anesthetic for secondary puncture.
Follicular lymphoma: State‐of‐the‐art ICML workshop in Lugano 2015
Authors: Gascoyne Randy D. , Nadel Bertrand , Pasqualucci Laura , Fitzgibbon Jude , Payton Jacqueline E. , Melnick Ari , Weigert Oliver , Tarte Karin , Gribben John G. , Friedberg Jonathan W. , Seymour John F. , Cavalli Franco , Zucca Emanuele 
Published: April 2017

AbstractThe 13th International Conference on Malignant Lymphoma held in Lugano in June 2015 was preceded by a closed workshop (organized in collaboration with the American Association for Cancer Research and the European School of Oncology) with the aim of developing an up‐to‐date understanding of the biology of follicular lymphoma and the clinical implications of new findings in the field. Discussed topics included the mutational spectrum at diagnosis, the clinical correlates of genetic and epigenetic alterations, the mechanisms of clonal evolution and histological transformation, the cross talk between tumor cells and microenvironment, and the development of novel treatments. This report represents a summary of the workshop.
Review of clinical indicators, including serum anti‐Müllerian hormone levels, for identification of women who should consider egg freezing
Authors: Martyn Fiona , O'Brien Yvonne M. , Wingfield Mary 
Published: April 2017

AbstractObjectiveTo identify women, on the basis of clinical history and serum anti‐Müllerian hormone (AMH) levels, who are at risk of premature ovarian insufficiency and thereby guide appropriate early referral for egg freezing.MethodsIn a retrospective study, data were reviewed from women attending two fertility clinics in Dublin, Ireland, between August 2011 and December 2012. Case histories of women aged 35 years or younger were assessed to identify risk factors for reduced ovarian reserve, including endometriosis, ovarian surgery, and family history of premature ovarian failure (POF).ResultsAmong 490 women aged 35 years or younger, 195 (39.7%) had an AMH level below 10 pmol/L, 94 (19.2%) had an AMH below 5 pmol/L, and 21 (4.3%) had an AMH below 1 pmol/L. Among 104 women aged 30 years or younger, the respective numbers were 28 (26.9%), 15 (14.4%), and 9 (8.7%). Among the 490 women, significantly lower AMH levels were observed for those with endometriosis (P=0.017) and a family history of POF (P=0.006). However, 53 (56.4%) of 94 women aged 35 years or younger with low AMH levels had no clinical risk factors.ConclusionUniversal AMH screening should be considered for all women in their 30s who are not ready to try to conceive; clinical risk factors will only identify approximately 50% of women at risk of low ovarian reserve.
Graphene as multifunctional delivery platform in cancer therapy
Authors: Nejabat Mojgan , Charbgoo Fahimeh , Ramezani Mohammad 
Published: April 2017

AbstractThe biomedical applications of graphene‐based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene‐based materials in introducing an effective cargo delivery system for cancer therapy. Different approaches for reducing cytotoxic impacts of graphene oxide and production of biocompatible delivery platform were also reviewed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2355–2367, 2017.
The Long Non‐Coding RNA TP73‐AS1 Interacted With miR‐142 to Modulate Brain Glioma Growth Through HMGB1/RAGE Pathway
Authors: Zhang Rong , Jin Hekun , Lou Fan 
Published: April 2017

ABSTRACTP73 antisense RNA 1T (non‐protein coding), also known as TP73‐AS1 or PDAM, is a long non‐coding RNA which may regulate apoptosis via regulation of p53‐dependent anti‐apoptotic genes. An abnormal change of TP73‐AS1 expression was noticed in cancers. The effects of TP73‐AS1 in brain glioma growth and the underlying mechanism remain unclear so far. In the present study, TP73‐AS1 was specifically upregulated in brain glioma tissues and cell lines, and was associated with poorer prognosis in patients with glioma. TP73‐AS1 knocking down suppressed human brain glioma cell proliferation and invasion in vitro, as well as HMGB1 protein. MiR‐142 has been reported to play a pivotal role in cancers; here we observed that TP73‐AS1 and miR‐142 could negatively regulate each other. Results from luciferase assays suggested that TP73‐AS1 might compete with HMGB1 for miR‐142 binding. Further, HMGB1/RAGE was involved in TP73‐AS1/miR‐142 regulation of glioma cell proliferation and invasion. In glioma tissues, TP73‐AS1 and HMGB1 expression was up‐regulated, whereas miR‐142 expression was down‐regulated. Data from the present study revealed that TP73‐AS1 promoted the brain glioma growth and invasion through acting as a competing endogenous RNA (ceRNA) to promote HMGB1 expression by sponging miR‐142. In conclusion, we regarded TP73‐AS1 as an oncogenic lncRNA promoting brain glioma proliferation and invasion, and a potential target for human brain glioma treatment. J. Cell. Biochem. 119: 3007–3016, 2018. © 2017 Wiley Periodicals, Inc.
Increased von Willebrand factor over decreased ADAMTS‐13 activity is associated with poor prognosis in patients with advanced non‐small‐cell lung cancer
Authors: Guo Renyong , Yang Jiezuan , Liu Xia , Wu Jianping , Chen Yu 
Published: April 2017

BackgroundHypercoagulability induced by the imbalance between von Willebrand factor (VWF) secretion and its cleaving protease (ADAMTS‐13) has been correlated with cancer metastasis. The aim of this study was to explore the prognostic significance of the VWF/ADAMTS‐13 ratio in advanced non‐small‐cell lung cancer (NSCLC).MethodsPre‐treatment sera/plasma levels of VWF, ADAMTS‐13, VWF/ADAMTS‐13 ratio, factor (F) VIII, and other clinical/laboratory parameters were measured in 119 patients with advanced NSCLC and 102 healthy controls. All patients were followed up to determine the predictive value of these parameters for prognosis of advanced NSCLC.ResultsElevated VWF, VWF/ADAMTS‐13 ratio, and reduced ADAMTS‐13 were significantly correlated with the stage and grade of advanced NSCLC and the final status of disease (P<.05). VWF levels and the VWF/ADAMTS‐13 ratio were also associated with response to chemotherapy (P<.05). Multivariate analysis identified the VWF/ADAMTS‐13 ratio and D‐dimer as significant independent predictors of patient mortality. The area under the curve showed that the VWF/ADAMTS‐13 ratio was more useful than VWF, ADAMTS‐13, and D‐dimer to predict mortality. Kaplan‐Meier analysis showed that a low VWF/ADAMTS‐13 ratio was significantly predictive of improved survival (P=.004).ConclusionThese results suggest that the imbalance between VWF secretion and ADAMTS‐13 may play a critical role in the hypercoagulability state in advanced NSCLC. Moreover, elevation of the plasma VWF/ADAMTS‐13 ratio may serve as an independent predictive factor for mortality in patients with advanced NSCLC.
Determinant roles of gender and age on SII, PLR, NLR, LMR and MLR and their reference intervals defining in Henan, China: A posteriori and big‐data‐based
Authors: Meng Xianchun , Chang Qian , Liu Yuying , Chen Ling , Wei Gaohui , Yang Jingjing , Zheng Peiguo , He Fucheng , Wang Wanhai , Ming Liang 
Published: April 2017

ObjectivesBy now, there are few data of the reference intervals (RIs) of SII, PLR, NLR, LMR and MLR. We aimed to establish RIs of SII, PLR, NLR, LMR and MLR for healthy persons.MethodsA retrospective analysis on a cohort of ostensibly healthy, aged no <18 years old physical examinees who took health examination from January to December in 2013 was conducted to explore influences of age and gender on SII, PLR, NLR, LMR and MLR and to establish their RIs. And another cohort of 450 persons in our hospital from January to July in 2016 is included for validations of RIs.ResultsNLR, LMR and MLR were significantly different between gender groups (P=.010; P<.001; P<.001, separately), while SII and PLR were not (P=.137; P=.267, separately). While SII was not changed much between age groups (P=.842), PLR, NLR, LMR and MLR were significantly different (all with P<.001). RIs of SII, PLR, NLR, LMR and MLR were: SII: [161,701]; PLR: 18‐65 year‐old: [61,179]/>65 year‐old: [55,179]; NLR: 18‐65 year‐old male: [0.90,2.94]/18‐65 year‐old female: [0.85,3.06]/>65 year‐old male: [0.95,3.57]/aged >65 year‐old female: [0.83,3.30]; LMR: 18‐65 year‐old male: [2.50,7.50]/18‐65 year‐old female: [2.75,8.50]/>65 year‐old male: [2.16,7.41]/>65 year‐old female: [2.40,8.33]; MLR: 18‐65 year‐old male: [0.12,0.35]/18‐65 year‐old female: [0.10,0.32]/>65 year‐old male: [0.12,0.41]/>65 year‐old male: [0.11,0.33].ConclusionsRIs of SII, PLR, NLR, LMR and MLR of people in central China were established and validated. It will benefit experimental design of the related studies and lead to better standardizations of SII, PLR, NLR, LMR and MLR for their clinical applications.
Nuclear spatial and spectral features based evolutionary method for meningioma subtypes classification in histopathology
Authors: Fatima Kiran , Majeed Hammad , Irshad Humayun 
Published: April 2017

AbstractMeningioma subtypes classification is a real‐world multiclass problem from the realm of neuropathology. The major challenge in solving this problem is the inherent complexity due to high intra‐class variability and low inter‐class variation in tissue samples. The development of computational methods to assist pathologists in characterization of these tissue samples would have great diagnostic and prognostic value. In this article, we proposed an optimized evolutionary framework for the classification of benign meningioma into four subtypes. This framework investigates the imperative role of RGB color channels for discrimination of tumor subtypes and compute structural, statistical and spectral phenotypes. An evolutionary technique, Genetic Algorithm, in combination with Support Vector Machine is applied to tune classifier parameters and to select the best possible combination of extracted phenotypes that improved the classification accuracy (94.88%) on meningioma histology dataset, provided by the Institute of Neuropathology, Bielefeld. These statistics show that computational framework can robustly discriminate four subtypes of benign meningioma and may aid pathologists in the diagnosis and classification of these lesions.
Travel medicine: Part 2—Special situations
Authors: Kamata Kazuhiro , Birrer Richard B , Tokuda Yasuharu 
Published: April 2017

AbstractTravel should be educational, fun, and safe if the appropriate care is rendered by counseling physicians and travelers take an active role in their health. In the second paper of the 2‐part special articles, we provide a practical summary of up‐to‐date travel medicine about special situations for primary care physicians. We focus on in‐flight emergencies, pregnancy, and specific precautions for injury and infectious disease as special situations. Physicians are frequently called upon to examine patients with in‐flight emergencies, and thus, they should have knowledge and skills for effectively caring patients. Common health problems over the flights include syncope, chest pain, dyspnea, and gastrointestinal symptoms. Cautious and prudent behaviors should be recommended for travelers to prevent injury and infectious disease. Follow‐up after the return home optimizes a positive outcome.
Influence of biofilm surface layer protein A (BslA) on the gel structure of myofibril protein from chicken breast
Authors: Ullah Niamat , Wang Xuejiao , Chen Lin , Xu Xinglian , Li Zhixi , Feng Xianchao 
Published: April 2017

AbstractBACKGROUNDDifferent techniques have been applied to alter myofibril protein (MP) structure, which further promotes protein–protein interactions and influencing the MP gelling characteristics. Influence of BslA from natto food (protein concentration, 30 mg mL−1; at 0.001, 0.005, 0.01, 0.05 and 0.1 g kg−1) on the characteristics of MP gel of chicken breast was investigated.RESULTSResults show that cooking loss significantly (P < 0.05) decreased with increased percentage of BslA. Hardness of MP gel did not significantly change at 0.01 g kg−1 BslA. Differential scanning calorimetry disclosed that MP was modified by the addition of BslA. Moreover, BslA produced a high value of storage modulus (G′) and low value of phase angle (tan δ) during heating, especially at 0.01 g kg−1. Analysis by sodium dodecyl sulfate–polyacrylamide gel electrophoresis analysis proved the formation of higher‐molecular‐weight polymers by developing non‐disulfide covalent bonds between MP at 0.01 g kg−1 BslA. Surface hydrophobicity of the MP gel was decreased with increased percentage of BslA. Scanning electron microscopy confirmed the increasing number of uniform cavities of MP gel with the increased percentage of BslA.CONCLUSIONAddition of 0.01 g kg−1 BslA significantly improved the water holding capacity and rheological properties of MP by developing non‐disulfide covalent bonds. © 2017 Society of Chemical Industry
Phenolic compounds, antioxidant potential and antiproliferative potential of 10 common edible flowers from China assessed using a simulated in vitro digestion–dialysis process combined with cellular assays
Authors: Huang Weisu , Mao Shuqin , Zhang Liuquan , Lu Baiyi , Zheng Lufei , Zhou Fei , Zhao Yajing , Li Maiquan 
Published: April 2017

AbstractBACKGROUNDPhenolic compounds could be sensitive to digestive conditions, thus a simulated in vitro digestion–dialysis process and cellular assays was used to determine phenolic compounds and antioxidant and antiproliferative potentials of 10 common edible flowers from China and their functional components.RESULTSGallic acid, ferulic acid, and rutin were widely present in these flowers, which demonstrated various antioxidant capacities (DPPH, ABTS, FRAP and CAA values) and antiproliferative potentials measured by the MTT method. Rosa rugosa, Paeonia suffruticosa and Osmanthus fragrans exhibited the best antioxidant and antiproliferative potentials against HepG2, A549 and SGC‐7901 cell lines, except that Osmanthus fragrans was not the best against SGC‐7901 cells. The in vitro digestion–dialysis process decreased the antioxidant potential by 33.95–90.72% and the antiproliferative potential by 13.22–87.15%. Following the in vitro digestion–dialysis process, phenolics were probably responsible for antioxidant (R2 = 0.794–0.924, P < 0.01) and antiproliferative (R2 = 0.408–0.623, P < 0.05) potential. Moreover, gallic acid may be responsible for the antioxidant potential of seven flowers rich in edible flowers.CONCLUSIONThe antioxidant and antiproliferative potential of 10 edible flowers revealed a clear decrease after digestion and dialysis along with the reduction of phenolics. Nevertheless, they still had considerable antioxidant and antiproliferative potential, which merited further investigation in in vivo studies. © 2017 Society of Chemical Industry
Seed priming with KNO3 mediates biochemical processes to inhibit lead toxicity in maize (Zea mays L.)
Authors: Nawaz Fahim , Naeem Muhammad , Akram Asim , Ashraf Muhammad Y , Ahmad Khawaja S , Zulfiqar Bilal , Sardar Hasan , Shabbir Rana N , Majeed Sadia , Shehzad Muhammad A , Anwar Irfan 
Published: April 2017

AbstractBACKGROUNDAccumulation of lead (Pb) in agricultural soils has become a major factor for reduced crop yields and poses serious threats to humans consuming agricultural products. The present study investigated the effects of KNO3 seed priming (0 and 0.5% KNO3) on growth of maize (Zea mays L.) seedlings exposed to Pb toxicity (0, 1300 and 2550 mg kg−1 Pb).RESULTSPb exposure markedly reduced the growth of maize seedlings and resulted in higher Pb accumulation in roots than shoots. Pretreatment of seeds with KNO3 significantly improved the germination percentage and increased physiological indices. A stimulating effect of KNO3 seed priming was also observed on pigments (chlorophyll a, b, total chlorophyll and carotenoid contents) of Pb‐stressed plants. Low translocation of Pb from roots to shoots caused an increased accumulation of total free amino acids and higher activities of catalase, peroxidase, superoxide dismutase and ascorbate peroxidase in roots as compared to shoot, which were further enhanced by exogenous KNO3 supply to prevent Pb toxicity.CONCLUSIONMaize accumulates more Pb in roots than shoot at early growth stages. Priming of seeds with KNO3 prevents Pb toxicity, which may be exploited to improve seedling establishment in crop species grown under Pb contaminated soils. © 2017 Society of Chemical Industry
The changing face of petrous apicitis—a 40‐year experience
Authors: Gadre Arun K. , Chole Richard A. 
Published: April 2017

Objectives/HypothesisPetrous apicitis (PA) is a rare complication of otitis media. Gradenigo syndrome, with the classic triad of otitis, deep pain, and abducens paralysis, is rarer still. The objective of this study was to determine if clinical presentation and management has changed over time.Study DesignRetrospective chart review.MethodsForty‐four patients with PA over a 40‐year period were studied. Symptoms, signs, and management outcomes were studied. Historical review, surgical anatomy and approaches, pathology, and microbiology, and an illustrative case are included as appendices.ResultsThe classical Gradenigo triad of retro‐orbital pain, otitis, and abducens palsy occurred in only six of 44 patients (13.6%). Over the 40‐year observation period, those needing surgery has decreased.ConclusionsAntibiotics remain the primary treatment modality. Surgery is reserved for cases failing to respond to antibiotics. One of the 44 patients in this series died of his disease. Diagnosis and management algorithms based on these observations are suggested.Level of Evidence4. Laryngoscope, 128:195–201, 2018
Novel assessment tool based on laser speckle contrast imaging to diagnose severe ischemia in the lower limb for patients with peripheral arterial disease
Authors: Katsui Sotaro , Inoue Yoshinori , Igari Kimihiro , Toyofuku Takahiro , Kudo Toshifumi , Uetake Hiroyuki 
Published: April 2017

ObjectiveWe propose a new assessment tool to diagnose severe ischemia of the lower limb in peripheral arterial disease, using laser speckle contrast imaging to evaluate heating‐induced microcirculatory fluctuations in the proximal and distal sites of the dorsal foot.Study DesignA cross‐sectional study.MethodsWe recorded the slope describing the behavior of perfusion values (decrease or plateau) following the initial, heating‐induced increase in perfusion in 63 feet of patients with clinical signs of peripheral arterial disease.ResultsThe plateau and decrease groups were defined as having perfusion slopes of <0.20 and ≥0.20 PU/min, respectively. Transcutaneous oxygen tension was significantly lower (P < 0.001) in the plateau than in the decrease group (8 vs. 45 mmHg), indicating more severe ischemia. The laser speckle contrast imaging thermal load test discriminated transcutaneous oxygen tension <30 mmHg with good sensitivity (78.7%) and specificity (96.2%), and an area under the curve of 0.908.ConclusionsBoth transcutaneous oxygen tension and the laser speckle contrast imaging thermal load test are useful in diagnosing severe ischemia in the foot. Lasers Surg. Med. 49:645–651, 2017. © 2017. The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.