bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemosensory anhedonia facilitates depressive symptoms and cognitive impairment in late‐life depression
Authors: Li Jiafu , Chen Ben , Wang Qiang , Xu Danyan , Lu Hanna , Lin Gaohong , Yang Mingfeng , Lao Jingyi , Zeng Yijie , Liang Shuang , Yao Kexin , Liu Qin , Huang Yuanling , Liu Xiaoxi , Zhong Xiaomei , Ning Yuping 
Published: September 2024

AimChemosensory anhedonia refers to the lack of hedonic ability to experience pleasure through the senses of smell and taste, which reduces the pleasure and comfort of food, and increases the risk of nutritional and immune deficiencies. However, there is no direct scientific evidence regarding chemosensory anhedonia in patients with late‐life depression (LLD). The aim of this study was to investigate chemosensory anhedonia in patients with LLD, and its potential association with depressive symptoms and cognitive function.MethodsA total of 114 patients with LLD and 92 normal controls were included in this study. They experienced clinical assessment, Chemosensory Pleasure Scale assessment, 17‐item Hamilton Depression Rating Scale assessment and cognitive assessments, which contain the Verbal Fluency Test. The associations between chemosensory pleasure and depressive symptoms or cognitive function in patients with LLD were explored using partial correlation analysis and mediation analysis.ResultsThe Chemosensory Pleasure Scale scores were lower in the LLD group than in the normal control group, and were negatively correlated with the total scores and factors' scores (retardation, cognitive bias and anxiety/somatization) of the 17‐item Hamilton Depression Rating Scale, and positively correlated with the Verbal Fluency Test scores. The scores for the Food and Imagination dimensions of the Chemosensory Pleasure Scale showed partial mediating effects on the differences in Cognitive bias (a factor of the 17‐item Hamilton Depression Rating Scale) between patients with LLD and normal controls.ConclusionsPatients with LLD showed significant chemosensory anhedonia, and both depressive symptoms and cognitive impairment were associated with the severity of chemosensory anhedonia. Enhancing chemosensory pleasure in patients with LLD could potentially ameliorate their depressive symptoms. Geriatr Gerontol Int 2024; ••: ••–••.
Heightened migraine risk in patients with rheumatoid arthritis: A national retrospective cohort study
Authors: Kang Seonyoung , Eun Yeonghee , Han Kyungdo , Jung Jinhyung , Kim Hyungjin , Min Ju‐Hong , Lee Seulkee , Cha Hoon‐Suk , Shin Dong Wook , Lee Jaejoon 
Published: September 2024

AbstractObjectiveThis study aimed to evaluate the association between rheumatoid arthritis (RA) and subsequent migraine risk using the Korean National Health Insurance Service database.BackgroundMigraine may be related to immune dysfunction and previous studies have suggested an association with chronic inflammatory rheumatic diseases; however, the relationship between RA and migraine remains unclear.MethodsThis was a population‐based, nationwide, retrospective, longitudinal cohort study. Participants were enrolled from 2010 to 2017 and followed up until 2019. A total of 42,674 patients who had undergone a health checkup within 2 years prior to the initial diagnosis of RA were included in the study, after applying the exclusion criteria (previous migraine, other rheumatic disease, missing variables of interest). A non‐RA control was obtained by age and sex‐matching (1:5). Finally, 42,644 patients with RA were enrolled, with 213,370 individuals without RA included as controls. Among the patients with RA, 29,744 had seropositive RA (SPRA), and 12,900 had seronegative RA (SNRA). SPRA was defined by the International Classification of Diseases 10th revision (ICD‐10) code M05, prescription of disease‐modifying anti‐rheumatic drugs (DMARDs), and enrollment in a special copayment reduction program. SNRA was defined by the ICD‐10 code M06 and prescription of any DMARD. The primary endpoint was the occurrence of migraine incidents, defined using the ICD‐10 code of migraine (G43).ResultsA total of 22,294 migraine cases (17,912/213,370 [8.3%] in controls and 4382/42,674 [10.2%] in RA) were reported during a mean follow‐up of 4.4 years after a 1‐year lag period. Patients with RA had a 1.2‐fold higher risk of migraine compared with controls (adjusted hazard ratio [aHR] 1.21, 95% confidence interval [CI] 1.17–1.26). Increased risk of migraine was found in both patients with SNRA and SPRA compared with controls (aHR 1.20, CI 1.15–1.24 in SPRA; aHR 1.26, CI 1.19–1.34 in SNRA). Compared to patients with SNRA, those with SPRA did not demonstrate a heightened risk (aHR 0.94, CI 0.88–1.01). A significant interaction was confirmed between covariates (male, current smoker, those with diabetes mellitus, and dyslipidemia) and the risk of migraine (p for interaction of <0.05).ConclusionRA was linked to a higher migraine risk, regardless of seropositivity.
Investigating the impact of product‐to‐package volume ratio on strawberry quality within modified humidity packaging systems
Authors: Zhang Qing , Yu Jiang , Wang Zhen 
Published: September 2024

SummaryTo reduce high humidity, minimise postharvest losses and optimise packaging volume, this study examines the effects of different product‐to‐package volume ratios (G/P) in modified humidity packaging systems using perforated containers and moisture conditioning agents. Strawberries were stored at 20 °C and 50% RH for 7 days with G/P ratios of 1:24, 1:12, 1:6 and 1:4, and their sensory and physicochemical properties were evaluated. The results show that moisture‐controlled packaging effectively preserves strawberry quality compared to non‐humidified packaging. Strawberries with a G/P of 1:24 in humidified packs had the best colour, aroma and texture on day 7. Higher G/P ratios correlated with increased quality deterioration. The lowest deterioration rates were observed in the G/P 1:24 and 1:12 groups, which also had the highest levels of vitamin C (54.72 mg/100 g and 55.40 mg/100 g), anthocyanins (1.086 ΔOD g−1 and 0.966 ΔOD g−1) and flavonoids (0.748 ΔOD g−1 and 0.726 ΔOD g−1). Although hardness, TSS and TA showed no significant correlation, these parameters were better in moderate G/P groups (1:12 and 1:6). These findings suggest that combining perforation with humidifiers in packaging can enhance the storage quality of fruits and vegetables while reducing packaging costs.
Effect of green extraction techniques on the quality and functional attributes of protein isolates from cereals and pseudo cereals: a review
Authors: Bharti Priyanka , Mohapatra Minati , Sah Rameswar Prasad , Pradhan Asit , Priyadarsani Supriya , Rayaguru Kalpana 
Published: September 2024

SummaryCereals and pseudo cereals (CPC) constitute the main staple diet of the global population. These are great source of carbohydrate, however, ignored as a potential source of protein. Cereals and Pseudo cereals can provide adequate amount of protein if taken in right quantity. Concerns over foods security, nutritional deficiencies, chronic hunger, and sustainability have brought attention to sustainable and alternative sources of protein derived from food and its byproducts. This review explains the extraction of protein from different cereals and pseudo cereals sources, novel extraction techniques, e.g., microwave assisted, ultrasound, pulsed electric field or high‐pressure processing etc., as well as pre‐treatment efficiencies of the recovery of protein, effects of process parameters on the amount of protein extractions, its isolations and possible utilisation in diversified fields. Commercial attempts have been made to extract and use the protein from CPC, but they remain largely underutilised and generally applicable to a small‐scale level. According to the current investigation, protein extraction from CPC is not only an extensive integration of extraction perspectives, process parameters, yield potential and quality, but also should focus on the nutritional aspects, functionality and bioavailability of the separated protein as a desirable dietary component is in the near future.
Screening of fermented milks with Lactococcus and Lactobacillus strains isolated from artisanal Mexican cheeses by the evaluation of the in vitro inhibition of enzymes associated to neurodegeneration
Authors: Castro‐Salomón Maritza , Beltrán‐Barrientos Lilia M. , González‐Córdova Aarón F. , Hernández‐Mendoza Adrián , Torres‐Llanez María J. , Vallejo‐Cordoba Belinda 
Published: September 2024

SummaryThe objective was to evaluate the in vitro inhibition of enzymes related to neurodegeneration (prolyl endopeptidase, PEP; acetylcholinesterase, AChE; butyrylcholinesterase, BChE; lipoxygenase, LOX) and the antioxidant activity from fermented milks (FM) with Lactococcus and Lactobacillus spp. All FM presented antioxidant activity (ABTS and ORAC); however, FM with Lactococcus NRRL B‐50571 (FM‐571) presented higher (P < 0.05) oxidative haemolysis inhibition. Additionally, FM‐571 presented the lowest IC₅₀ for LOX (1.78 mg/mL), PEP (3.16 mg/mL), AChE (3.22 mg/mL) and BChE (2.14 mg/mL). Thus, FM‐571 was selected for in silico analysis for the prediction of binding sites of peptides present in this FM with enzymes active sites. Altogether, thirty peptides showed (P < 0.01) high binding potential to AChE, seventeen to BChE and LOX and sixteen to PEP. Thus, FM‐571 shows potential for the development of dairy products with potential neuroprotective effects.
Effect of carbon dioxide on anthocyanins and sucrose synthesis of red onion (Allium cepa L.) during post‐harvest storage
Authors: Nassarawa Sanusi Shamsudeen , Oluwalana Isaac Babatunde , Rafique Hamad , Alsulami Tawfiq , Nayik Gulzar Ahmad 
Published: September 2024

SummaryThis study examined the impact of CO2 on the quality of onions stored at 23 °C for 6 weeks, focussing on bioactive compounds, antioxidant capacity, individual anthocyanins, flavonoids and anthocyanin biosynthesis during the storage period. The findings revealed that a 20% CO2 treatment was markedly more effective than the control in maintaining higher levels of phenolics, flavonoids, flavanols and anthocyanins. Moreover, the 20% CO2 treatment preserved significantly higher quantities of individual anthocyanins and flavonoids compared to the control. Throughout storage, the 20% CO2 treatment significantly boosted the activity of enzymes related to anthocyanin biosynthesis and sucrose metabolism relative to the control groups. In summary, the innovation of this study lies in the use of CO2 to maximise anthocyanin and flavonoid content in stored onions, which are usually diminished by extended storage at room temperature. This method could help extend the shelf life of onions while preserving their quality attributes.
Fc‐FcγR interactions during infections: From neutralizing antibodies to antibody‐dependent enhancement
Authors: Edgar Julia E. , Bournazos Stylianos 
Published: September 2024

SummaryAdvances in antibody technologies have resulted in the development of potent antibody‐based therapeutics with proven clinical efficacy against infectious diseases. Several monoclonal antibodies (mAbs), mainly against viruses such as SARS‐CoV‐2, HIV‐1, Ebola virus, influenza virus, and hepatitis B virus, are currently undergoing clinical testing or are already in use. Although these mAbs exhibit potent neutralizing activity that effectively blocks host cell infection, their antiviral activity results not only from Fab‐mediated virus neutralization, but also from the protective effector functions mediated through the interaction of their Fc domains with Fcγ receptors (FcγRs) on effector leukocytes. Fc‐FcγR interactions confer pleiotropic protective activities, including the clearance of opsonized virions and infected cells, as well as the induction of antiviral T‐cell responses. However, excessive or inappropriate activation of specific FcγR pathways can lead to disease enhancement and exacerbated pathology, as seen in the context of dengue virus infections. A comprehensive understanding of the diversity of Fc effector functions during infection has guided the development of engineered antiviral antibodies optimized for maximal effector activity, as well as the design of targeted therapeutic approaches to prevent antibody‐dependent enhancement of disease.
Harambee as a decolonial digital fundraising approach
Authors: Frimpong Bright , Ayaburi Emmanuel W. , Andoh‐Baidoo Francis Kofi 
Published: September 2024

AbstractDeployment of digital crowdfunding platforms, which predominantly are designed in line with Western norms, into Indigenous communities often leads to significant cultural tensions. This study uses the Kenyan Indigenous tradition of Harambee to elucidate how these cultural tensions manifest and are navigated in the context of digital crowdfunding. The study employs a qualitative approach, conducting narrative interviews with individuals experienced in both Harambee and digital crowdfunding within the Kenyan context, to advance our understanding of decolonial digital crowdfunding. The findings reveal significant cultural tensions, including those related to inclusive access, diminished communal engagement and erosion of social capital. These tensions highlight the marginalisation of Indigenous cultures and the reinforcement of colonial tendencies in digital spaces. Additionally, the study uncovers the ingenuity of Indigenous users who are integrating Indigenous knowledge and Harambee norms with digital technologies, to balance cultural sensitivity, strengthen technological inclusivity and preserve their communal values within decolonial digital fundraising. This study advances decolonial scholarship by demonstrating how the integration of both Indigenous and local practices with digital technology not only advances digital decoloniality but also enriches the technology's cultural responsiveness. The findings have practical implications for designing inclusive digital crowdfunding platforms that acknowledge and align with local cultural norms.
Hidradenitis suppurativa and its association with obesity, smoking, and diabetes mellitus: A systematic review and meta‐analysis
Authors: Elzawawi Khaled E. , Elmakaty Ibrahim , Habibullah Mohammad , Ahmed Mohamed Badie , Al Lahham Salim , Al Harami Sara , Albasti Habib , Alsherawi Abeer 
Published: September 2024

AbstractOur meta‐analysis aimed to quantify the association between Hidradenitis suppurativa (HS) and several risk factors including obesity, smoking, and type 2 diabetes mellitus (T2DM). We searched PubMed, Scopus, Embase, Web of Science, and cumulative index to nursing and allied health literature for articles reporting either the odds ratio (OR) or the numbers of HS cases associated with obesity, smoking, or T2DM, and including HS negative controls. Risk of bias was assessed against the risk of bias in non‐randomized studies of interventions tool. Data synthesis was done using the random effects model with heterogeneity being evaluated with I2 statistic. Twenty‐three studies with a total of 29 562 087 patients (average age of 36.6 years) were included. Ten studies relied on country‐level data, while six studies collected their data from HS clinics. The analysis showed a significant association between HS and female sex (OR 2.34, 95% CI 1.89–2.90, I2 = 98.6%), DM (OR 2.78, 95% CI 2.23–3.47, I2 = 98.9%), obesity (OR 2.48, 95% CI 1.64–3.74, I2 = 99.9%), and smoking (OR 3.10 95% CI 2.60–3.69, I2 = 97.1%). Our meta‐analysis highlights HS links to sex, DM, obesity, and smoking, with emphasis on holistic management approach. Further research is needed on molecular mechanisms and additional risk factors for improved patient care.
Strategies to improve oxidation resistance of MgO–C refractories by decreasing oxygen potential through MgSiN2
Authors: Meng Fanqiang , Luo Yixin , Liu Zhenglong , Yu Chao , Deng Chengji , Ding Jun 
Published: September 2024

AbstractMgO–C refractories are of paramount importance in the converter side blowing system, requiring outstanding oxidation resistance under harsh conditions including high temperature, oxygen atmosphere, and high‐speed airflow. In this study, MgSiN2 phase reconstruction was used to improve the oxidation resistance of MgO–C refractories, as well as the mechanical properties and oxidation resistance of MgO–C refractories were evaluated. The results indicated that the cold modulus of rupture of the sample with 9 wt% MgSiN2 was increased by 93.3% compared with the MgO–C refractories without MgSiN2. After oxidation tests, the oxidation index and rate constant (k) of the sample with 9 wt% MgSiN2 were reduced by 38.9% and 35.3%. Furthermore, incorporating MgSiN2 facilitated the formation of layered dense structures consisting of plate‐like Mg‐Sialon and MgO–Mg2SiO4–MgAl2O4. This structural optimization effectively inhibited oxygen diffusion and reaction within the material, resulting in gradual oxygen potential mitigation.
Using a Capability Approach to Explore How People With Intellectual Disabilities Can Lead Flourishing Lives
Authors: Ryan Sara , O'Brien Rosaleen 
Published: September 2024

ABSTRACTBackgroundPeople with intellectual disabilities remain disadvantaged in many aspects of everyday life. Capability approach is an underused approach in social care research and has at its core the importance of having capabilities or opportunities to do what we value. We use this approach to explore how people with intellectual disabilities can be supported to lead flourishing lives.MethodsInterviews and focus groups were conducted with 50 people with intellectual disabilities and 28 family carers. Data were analysed using an adapted template approach and conceptual analysis.ResultsOur analysis led to the identification of one overarching theme; ‘Doing what you love and growing’ and sub‐themes; ‘Choice, opportunity and empowerment’, ‘Being out in the world’ and ‘Lowered expectations and static lives’.ConclusionPeople with intellectual disabilities can lead capability‐deprived lives. Methodological and practice innovation is needed to better understand what people value and ensure they have capability sets that enable flourishing lives.
Reshuffling of Azorean Coastal Marine Biodiversity Amid Climate Change
Authors: González‐Trujillo Juan David , Naimi Babak , Assis Jorge , Araújo Miguel B. 
Published: September 2024

ABSTRACTAimClimate change poses a challenge to the Azores' biodiversity, with consequences that remain unexplored. To shed light on the potential impacts of climate change, we have developed a large ensemble of species distribution models (SDMs) for species found in the coastal marine environments and examined their spatiotemporal turnover and stability.LocationThe Azorean archipelago.TaxonCoastal marine species (mammals, fish, turtles, seabirds, kelp forest and corals).MethodsSDMs were fitted a large ensemble comprising 10 machine learning algorithms and a fivefold cross‐validation resampling procedure, thus yielding a maximum number of 50 models fitted per species. These models were then utilised for projecting species distribution under different future scenarios. The projected distributions of the species were employed to assess changes in the stability of their ranges throughout the entire modelled period (2030–2100) and in their community compositions by examining changes in alpha diversity and beta diversity over 10‐year periods.ResultsWe show that under our model assumptions over 12% of the modelled units could lose suitable climate by the end of the century, with this number increasing up to 25% under a high carbon emissions scenario. Climate change refugia, which are areas of long‐term species range stability, are expected to be mainly located in the coastal areas in the northernmost part of the archipelago. A substantial loss of suitable climate is anticipated for mammals and birds, which is likely to trigger a major loss of species on the islands of Santa Maria, São Miguel, Pico and Faial. For fish, the loss of suitable climates is less pronounced. However, climate change is expected to cause a major reshuffling of the pelagic fish assemblage, with important consequences for local fisheries on each island.Main ConclusionsOur models provide insights into how climate change may alter the distribution of Azorean marine coastal species, offering important guidance for conservation and management efforts in these important North Atlantic ecosystems.
Levering AI to enhance students' conceptual understanding and confidence in mathematics
Authors: Canonigo Allan Mesa 
Published: September 2024

AbstractMotivationThis research investigates the transformative impact of integrating AI into mathematics education, aiming to enhance students' conceptual understanding and self‐efficacy. It addresses the crucial need for innovative teaching methods in response to contemporary challenges in education and aims to fill gaps in understanding the potential drawbacks and benefits of AI implementation.ObjectivesThe primary goal of this study is to investigate the effects of AI tools, such as GeoGebra and ChatGPT, on students' conceptual understanding and self‐efficacy in a mathematics classroom setting, with a focus on collaborative learning, teacher‐led discussions, and problem‐solving.MethodsEmploying a mixed‐methods approach, the research involves pre‐ and post‐implementation surveys, supplemented by qualitative data from interviews, focus groups, and classroom observations. The study emphasises the utilisation of AI in collaborative learning environments and explores the challenges and opportunities associated with its integration.Results and ConclusionsThe study reveals a noteworthy enhancement in students' conceptual understanding and self‐efficacy belief when AI tools are incorporated into mathematics education. However, it highlights concerns such as technological challenges, potential teacher replacement fears, biases in AI systems, and difficulties related to pacing and social interaction. To optimise the use of AI, the paper suggests strategies like adaptive learning platforms, real‐world simulations, intelligent tutoring systems, and data‐driven instruction, positioning AI as a complement rather than a substitute for traditional teaching methods. The study recommends addressing challenges through additional support resources and transparent communication, emphasising the need for a thoughtful integration of AI in education.