bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN HASIL BELAJAR PESERTA DIDIK MELALUI MEDIA ULAR TANGGA PADA MATA PELAJARAN IPS KELAS VIII SMP NUSANTARA INDAH SINTANG
Authors: Pelipa Emilia Dewiwati , Relita Dessy Triana , Wulandari Wulandari 
Published: September 2024

The purpose of this study was to describe the use of snakes and ladders learning media in improving student learning outcomes in social studies subjects in Class VIII of Nusantara Indah Sintang Junior High School in the 2023/2024 academic year. The method used in this research is qualitative research method. The subjects in this study were all students in class VIII of Nusantara Indah Junior High School Sintang in the 2023/2024 academic year, totalling 13 students, including 10 female students and 3 male students. The data collection techniques used were observation, interviews, documentation and test questions. Based on data analysis, the research results are as follows: (1) the application of snakes and ladders learning media is in accordance with the steps specified on the observation sheet. Judging from the results of teacher activity observations in cycle I was 90% and in cycle II was 100% with the assessment criteria for teacher activity observation results very well. (2) the improvement of students' learning outcomes can be seen from the test results, average scores, and classical completeness of each cycle. Where the average value of cycle I was 63.07 and the classical completeness was 53.84%, while the average value of cycle II was 88.46 and the classical completeness was 92.30%, meaning that snakes and ladders learning media can improve student learning outcomes. (3) Students' responses to the snakes and ladders learning media expressed positive responses based on statements on the students' interview sheets. It can be concluded that through snakes and ladders media can improve the learning outcomes of students in social studies class VIII SMP Nusantara Indah Sintang in the 2023/2024 academic year. Keywords: Learning Outcomes, Snakes and Ladders Learning Media
MEMBENTUK KARAKTER PELAJAR BEBAS NARKOBA DI SMPN 2 SINTANG
Authors: Suseka Septha , Fingky Winarto , Anjela Tersia 
Published: September 2024

The purpose of this article is to provide an overview of the phenomenon of drug abuse among teenagers and the efforts made to prevent it. This study was conducted with a qualitative approach and is descriptive in nature. Meanwhile, there are several steps that need to be taken to deal with the problem of drug abuse among teenagers. This includes prevention and education, anti-drug campaigns, and massive enforcement actions starting from families, schools, and communities. Therefore, parents must act democratically by treating their children or teenagers well and giving them enough attention. To prevent drug abuse among teenagers, schools must provide education and various information about the dangers of drugs. In society, every member of society must act firmly and consistently as social control to prevent drug abuse. The research results show that drugs have spread in Indonesia today, especially among teenagers. There is already a drug emergency in Indonesia, and everyone must pay attention to this. Meanwhile, there are several steps that need to be taken to deal with the problem of drug abuse among teenagers. This includes prevention and education, anti-drug campaigns, and massive enforcement actions starting from families, schools, and communities. Therefore, parents must act democratically by treating their children or teenagers well and giving them enough attention. To prevent drug abuse among teenagers, schools must provide education and various information about the dangers of drugs. In society, every member of society must act firmly and consistently as social control to prevent drug abuse.Keywords: Preventing Drug Abuse, Drug Abuse, Teenager
Advancing Parkinson’s Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort
Authors: Cressatti Marisa , Pinilla-Monsalve Gabriel D. , Blais Mathieu , Normandeau Catherine P. , Degroot Clotilde , Kathol Iris , Bogard Sarah , Bendas Anna , Camicioli Richard , Dupré Nicolas , Gan-Or Ziv , Grimes David A. , Kalia Lorraine V. , MacDonald Penny A. , McKeown Martin J. , Martino Davide , Miyasaki Janis M. , Schlossmacher Michael G. , Stoessl A. Jon , Strafella Antonio P. , Fon Edward A. , Monchi Oury 
Published: September 2024

Background: Enhancing the interactions between study participants, clinicians, and investigators is imperative for advancing Parkinson’s disease (PD) research. The Canadian Open Parkinson Network (C-OPN) stands as a nationwide endeavor, connecting the PD community with ten accredited universities and movement disorders research centers spanning, at the time of this analysis, British Columbia, Alberta, Ontario, and Quebec. Objective: Our aim is to showcase C-OPN as a paradigm for bolstering national collaboration to accelerate PD research and to provide an initial overview of already collected data sets. Methods: The C-OPN database comprises de-identified data concerning demographics, symptoms and signs, treatment approaches, and standardized assessments. Additionally, it collects venous blood-derived biomaterials, such as for analyses of DNA, peripheral blood mononuclear cells (PBMC), and serum. Accessible to researchers, C-OPN resources are available through web-based data management systems for multi-center studies, including REDCap. Results: As of November 2023, the C-OPN had enrolled 1,505 PD participants. The male-to-female ratio was 1.77:1, with 83% ( n = 1098) residing in urban areas and 82% ( n = 1084) having pursued post-secondary education. The average age at diagnosis was 60.2±10.3 years. Herein, our analysis of the C-OPN PD cohort encompasses environmental factors, motor and non-motor symptoms, disease management, and regional differences among provinces. As of April 2024, 32 research projects have utilized C-OPN resources. Conclusions: C-OPN represents a national platform promoting multidisciplinary and multisite research that focuses on PD to promote innovation, exploration of care models, and collaboration among Canadian scientists.
Recognizing facially expressed emotions in videos of people with visual impairments in online settings
Authors: Kim Hyung Nam 
Published: September 2024

BACKGROUND Facial expressions are critical for conveying emotions and facilitating social interaction. Yet, little is known about how accurately sighted individuals recognize emotions facially expressed by people with visual impairments in online communication settings. OBJECTIVE This study aimed to investigate sighted individuals’ ability to understand facial expressions of six basic emotions in people with visual impairments during Zoom calls. It also aimed to examine whether education on facial expressions specific to people with visual impairments would improve emotion recognition accuracy. METHODS Sighted participants viewed video clips of individuals with visual impairments displaying facial expressions. They then identified the emotions displayed. Next, they received an educational session on facial expressions specific to people with visual impairments, addressing unique characteristics and potential misinterpretations. After education, participants viewed another set of video clips and again identified the emotions displayed. RESULTS Before education, participants frequently misidentified emotions. After education, their accuracy in recognizing emotions improved significantly. CONCLUSIONS This study provides evidence that education on facial expressions of people with visual impairments can significantly enhance sighted individuals’ ability to accurately recognize emotions in online settings. This improved accuracy has the potential to foster more inclusive and effective online interactions between people with and without visual disabilities.
Effect of pelvic floor muscle exercise combined with infrared physiotherapy on postpartum urinary incontinence
Authors: Li Chunbo , Li Kejun 
Published: September 2024

BACKGROUND: Scientific treatments for postpartum urinary incontinence, including pelvic floor muscle exercises (such as Kegel exercises) and infrared therapy, can effectively improve pelvic floor and urethral function, thus enhancing quality of life. However, clinical research on the combined use of these interventions for postpartum urinary incontinence is limited. OBJECTIVE: To investigate the combining efficacy of pelvic floor muscle exercises with infrared physiotherapy on postpartum urinary incontinence. METHODS: Clinical information of 102 patients with postpartum urinary incontinence (June 2021–June 2022) were collected and analyzed. Patients were randomly divided into control (conventional intervention) and observation (pelvic floor muscle exercises combined with infrared physiotherapy) groups, with 52 and 50 cases respectively. We compared pelvic floor muscle strength, urodynamic indicators, leakage volume, quality of life, and overall clinical efficacy between the two groups. RESULTS: Before intervention, both groups had similar pelvic floor function scores and urodynamic indicators. Post-intervention, the pelvic floor function scores in the observation group were significantly lower than control. The urodynamic indicator levels of the observation group were markedly higher than control after 2 months of intervention. Leakage volume was similar before intervention, while the observation group had significantly lower volumes after 1 and 2 months of intervention. Quality of life scores were similar initially, but after 2 months, the observation group scored higher. The observation group showed notably better pelvic floor rehabilitation at 2 months post-intervention. CONCLUSION: Combining pelvic floor muscle exercise with infrared physiotherapy has been shown to be a highly effective approach in enhancing pelvic floor muscle strength and improving the quality of life for postpartum women experiencing urinary incontinence. This combined therapy also demonstrates positive effects on urodynamic indicators, reducing leakage volume, and facilitating pelvic floor rehabilitation.
Effect of patient position on the EEG bispectral index and entropy index under general anaesthesia
Authors: Chen Wending , Wang Jialin , Wang Luyang , Hu Wenwen , Chen Xinzhong , Jin Lin 
Published: September 2024

BACKGROUND: Perioperative depth monitoring techniques, such as electroencephalography bispectral index (BIS), entropy index, and auditory evoked potential, are commonly used to assess anesthesia depth. However, the influence of patient positioning changes, particularly in gynecological surgeries where a head-down position is often required, on the accuracy of these monitoring indices remains unexplored. OBJECTIVE: The aim of the our study was to observe the impact of patient position changes on the monitoring value of entropy and BIS to identify a more sensitive method of anaesthesia depth monitoring for gynaecological surgery patients. METHODS: We conducted a study involving 40 women undergoing general anesthesia, during which routine monitoring of vital signs, including electrocardiogram (ECG), heart rate (HR), noninvasive arterial blood pressure (NIBP), oxyhemoglobin saturation (SpO2), and end-expiratory carbon dioxide (PetCO2), was initiated. Entropy and BIS devices were affixed to the patients’ foreheads after alcohol sterilization to record brain activity. Tracheal intubation was performed following anesthesia induction. Throughout anesthesia maintenance, the value of BIS and response entropy (RE) were monitored and maintained between 40 and 50 by adjusting the infusion rate of propofol and remifentanil with Target Controlled Infusion (TCI, Mintopharmacokinetics model). Dosing for infusion control utilized corrected weight (height-105). Data were recorded before and after position changes, including tilting the operating table to head-down positions of 15 and 25 degrees, returning to a supine position, and elevating the head to 15 and 25-degree angles. BIS and entropy values at different time points were compared between the groups. RESULTS: Both BIS and entropy values increased from supine to head-down position and decreased from supine to head-up position, with entropy changes preceding those of BIS. Heart rate increased after head-up and decreased after head-down, while mean blood pressure (MBP) exhibited the opposite effect on heart rate. Significant correlations were found between heart rate and BIS (correlation coefficient: [Formula: see text]0.43) and RE (correlation coefficient: [Formula: see text]0.416), as well as between MBP and BIS (correlation coefficient: 0.346) and RE (correlation coefficient: 0.384). CONCLUSION: Changes in patient position can significantly affect the value of RE and BIS, as changes in entropy occur earlier than changes in the BIS.
Application of whole genome sequencing to assess the relatedness of Salmonella Enteritidis strains isolated in the Silesian Voivodeship
Authors: Rozwadowska Beata Irena , Albertyńska Marta , Hudzik Grzegorz 
Published: September 2024

BackgroundGram-negative Salmonella bacilli are one of the most common bacterial causes of gastrointestinal infections. Well-selected and targeted microbiological diagnostics enable the detection and identification of the etiological agent of infection, however, standardized, routine and recommended methods do not always allow for the identification of the biological agent in an unambiguous manner. Next-generation sequencing has become an ideal tool for identifying microorganisms and tracking infection transmission in outbreaks for epidemiological purposes.ObjectiveThe aim of the study was to assess the genomic relatedness of Salmonella Enteritidis strains using whole genome sequencing in the foodborne outbreak in August-September 2023 in the Silesian Voivodeship.Material and methodsThe research material consisted of 11 strains of S. Enteritidis for which whole genome sequencing was performed using Illumina technology and the relationship between serotypes was assessed using bioinformatics tools.ResultsThe genomes of all S. Enteritidis isolates were assigned to HC2_53128, which may indicate a very close relationship between the strains.ConclusionsWhole genome sequencing enabled the assessment of the genomic relatedness of S. Enteritidis strains in the foodborne outbreak in August-September 2023 in the Silesian Voivodeship.
A PRAGMATICS STUDY OF EXPRESSIVE ILLOCUTIONARY ACTS IN SEASON 2 OF THE SUMMER I TURNED PRETTY
Authors: Anastasya Fitri , Supri Ida Zuraida 
Published: September 2024

This thesis is entitled "A Pragmatic Study of Expressive Illocutionary Acts in Season 2 of The Summer I Turned Pretty". This research aims to identify the type of expressive illocutionary acts and also identify the context situation. The theory of expressive illocutionary act types by Searle and context situation by Hymes are used in this research. The method used is qualitative descriptive method. This research begins with choosing a research topic, formulating a research title, choosing a research method, collecting data, identifying data, classifying data, analyzing data, and finally making conclusions and suggestions. The results showed that from 40 research data found in The Summer I Turned Pretty season 2 series, there are 6 types of expressive illocutionary acts with the following description, 15 data (37.5%) expressive illocutionary acts of Thank you, 14 data (35%) expressive illocutionary acts of Forgive, 4 data (10%) expressive illocutionary acts of Welcome, 3 data (7.5%) expressive illocutionary acts of Condole, 3 data (7.5%) expressive illocutionary acts of Deplore, and 1 data (2.5%) expressive illocutionary acts of Congratulations. In terms of the SPEAKING context, there are 16 data (28.09%) of End, 6 data (10.91%) of Act Sequence, 12 data (21.82%) of Key and 21 data (338.18%) of Norm. This research concludes that expressive illocutionary acts in the series The summer I Turned Pretty season 2 are dominated by the types of expressive illocutionary acts of Thank you and Forgive. Meanwhile, the most dominant context situation is Norm.
Propuesta metodológica para el uso de la prosopografía en el Centro Universitario de Ciencias Económico Administrativas
Authors: Ruiz Ortega Mario 
Published: September 2024

Este artículo es una propuesta para la enseñanza de la prosopografía en el Centro Universitarios de Ciencias Económico Administrativas. Bosqueja sus inicios como herramienta de las ciencias sociales, hasta su consolidación como un método aceptado para la segunda mitad del siglo XX. Describe las dos grandes escuelas que identifican las estudios prosopográficos. Detalla una crisis metodológica sufrida en el último tercio del siglo. Aborda los principales pasos para su uso, acompañada esta última sección por reflexiones adecuadas para estudiantes universitarios de ciencias económico administrativas.
Comparative evaluation of serum and gingival crevicular fluid levels of interleukin 21 in periodontally diseased and healthy patients
Authors: Gulfishan Shabnam , Ahmed Syed Suhail , Reddy Pathakota Krishnanjeya , Krishnan Preethi , B Reddy Aravinda , Fazal Ibrahim 
Published: September 2024

Background: Periodontitis is an inflammatory reaction to subgingival pathogenic microorganisms that causes gradual deterioration of the gingiva, periodontal ligament, and alveolar bone. Interleukin (IL)-21 is the most recently found member of type I cytokine family that is upregulated during inflammation. The current study aims to investigate the biological plausibility of IL-21 as a biomarker for chronic periodontitis.
Materials and methods: This cross-sectional clinico-biochemical investigation included 15 systemically healthy, 15 periodontally healthy, 15 chronic gingivitis, and 15 chronic periodontitis subjects aged 25 to 60 years. Following subject enrollment, gingival crevicular fluid (GCF) and blood samples were then taken from each subject. The concentration of IL-21 in all samples was determined using enzyme-linked immunosorbent assay (ELISA) kit. The data was examined using the Kruskal-Wallis test and the Spearman correlation test.
Results: Serum IL-21 levels in chronic periodontitis patients were substantially greater than in periodontally healthy individuals. GCF IL-21 levels were substantially greater in gingivitis and chronic periodontitis patients compared to periodontally healthy individuals. In terms of clinical indicators, serum IL-21 levels correlated significantly with bleeding index (BI) in the chronic periodontitis group. In chronic periodontitis group, disease severity as evaluated by probing pocket depth (PPD) and clinical attachment loss (CAL) did not correlate with serum or GCF IL-21 levels.
Conclusion: According to the current study’s findings, periodontally involved patients had higher IL-21 levels than periodontally healthy patients, suggesting it can be used as biomarker. Further studies with larger sample size can shed more light on the clinical advantage of IL-21 as a possible marker for disease activity and progression.
Óbitos neonatais na 7ª Regional de Saúde do Estado do Paraná no período de 2017 a 2021
Authors: Marcolina Vanessa , Marcolina Rafaela , Nesi Camille Figueiró , Silva Jackson Antunes da , Andrade Mariana Maria Ferreira de , Mattei Taynara 
Published: September 2024

Objetivo: Analisar a frequência de óbitos neonatais e suas causas na 7ª Regional de Saúde do Estado do Paraná entre os anos de 2017 e 2021. Métodos: Trata-se de um estudo retrospectivo, ecológico realizado na região Sudoeste do estado do Paraná, na 7ª Regional de Saúde. A coleta de dados foi realizada a partir dos sistemas de informação de mortalidade infantil disponíveis sobre banco de dados nacional TABNET/DATASUS. A mortalidade foi analisada de acordoo com a causa descrita no CID-10 e com o período ocorrido sendo: neonatal precoce (0 a 6 dias) e neonatal tardio (7 a 27 dias). Resultados: Foram identificados 178 óbitos no primeiro mês de vida correspondendo a uma taxa de mortalidade de 8,6/1000 nascidos vivos. A maioria dos óbitos ocorreram em neonatais precoces (n= 138, 77,5%). A maioria dos óbitos ocorreu em decorrência de afecções originadas no período perinatal tanto para neonatais precoces (73,2%) quanto para os neonatais tardios (65,0%). Conclusão: Verificou-se uma taxa de mortalidade de 8,6/1000 nascidos vivos no período de 2017 a 2021 e que as afecções do período neonatal são a principal causa de óbitos neonatais na 7º Regional de Saúde do Estado do Paraná.
СУЧАСНЕ УКРАЇНСЬКЕ КОЗАЦТВО: ПАРАМІЛІТАРНИЙ ФАНТОМ МИНУЛОГО
Authors: Гула Руслан Володимирович , Михайловський Руслан Анатолійович 
Published: September 2024

У статті розкрито основні складники процесу відродження та розвитку сучасного козацького руху у період 1991–2015 рр. Проаналізовано його характерні риси організаційного оформлення та партійного будівництва в системі діалектичних протиріч. Виявлені тенденції трансформації ідеології козацького руху. З’ясовано особливості управлінсько-адміністративної діяльності козацьких керманичів, їхніх ролі та місця в процесах державотворення. Різноманіття основних напрямів козацтва розкрито через аналіз їх змісту та сутності. Окреслені суперечливі результати діяльності козацького руху в ході антитерористичної операції 2014–2015 рр.
YTHDF3 modulates the progression of breast cancer cells by regulating FGF2 through m6A methylation
Authors: Gong R. F. , Zhang Z. H. , Sun T. T. , Zhao Y. X. , Fang Wen 
Published: September 2024

IntroductionBreast cancer (BC) is a prevailing malignancy among women, and its inconspicuous development contributes significantly to mortality. The RNA N6-methyladenosine (m6A) modification represents an emerging mechanism for gene expression regulation, with the active involvement of the YTH N6-methyladenosine RNA binding protein 3 (YTHDF3) in tumor progression across multiple cancer types. Nonetheless, its precise function in breast cancer necessitates further investigation.MethodsThe expression of YTHDF3 in both cell lines and patient tissues was examined using Western blotting, reverse transcription quantitative PCR (RT-qPCR), and immunohistochemistry (IHC) techniques. Bioinformatics analysis of methylated RNA immunoprecipitation sequencing (MeRIP-seq) and transcriptome RNA sequencing (RNA-seq) data was employed to screen for the target genes of YTHDF3. The main focus of this study was to investigate the in vitro biological functions of YTHDF3. The specific binding of YTHDF3 to its target genes and its correlation with m6A methylation were studied through RNA pull-down, RNA immunoprecipitation, and co-immunoprecipitation experiments. The protein regulatory mechanisms of downstream genes of YTHDF3 were assessed using protein stability analysis. Furthermore, the biological functions of YTHDF3 and its target genes in breast cancer cells were validated through CRISPR-Cas9 technology and rescue experiments.ResultsBy constructing a risk model using the TCGA database, YTHDF3 was identified as a high-risk factor among m6A methylation factors. Subsequent investigations revealed its elevated expression in various subtypes of breast cancer, accompanied by poor prognosis. MeRIP-seq analysis further revealed fibroblast growth factor 2 (FGF2) as a downstream gene of YTHDF3. Knockdown of YTHDF3 in breast cancer cells led to significant inhibition of cell self-renewal, migration, and invasion abilities in vitro. Mechanistically, YTHDF3 specifically recognized the methylated transcript of FGF2 within its coding sequence (CDS) region, leading to the inhibition of FGF2 protein degradation. Moreover, depletion of FGF2 markedly suppressed the biological functions of breast cancer cells, while reducing FGF2 expression in YTHDF3-overexpressing breast cancer cell lines substantially alleviated the malignant progression.ConclusionsIn summary, our study elucidates the role of YTHDF3 as an oncogene in maintaining FGF2 expression in BC cells through an m6A-dependent mechanism. Additionally, we provide a potential biomarker panel for prognostic prediction in BC.