bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms
Authors: Emadali Anouk , Hoghoughi Neda , Duley Samuel , Hajmirza Azadeh , Verhoeyen Els , Cosset Francois-Loic , Bertrand Philippe , Roumier Christophe , Roggy Anne , Suchaud-Martin Céline , Chauvet Martine , Bertrand Sarah , Hamaidia Sieme , Rousseaux Sophie , Josserand Véronique , Charles Julie , Templier Isabelle , Maeda Takahiro , Bruder-Costa Juliana , Chaperot Laurence , Plumas Joel , Jacob Marie-Christine , Bonnefoix Thierry , Park Sophie , Gressin Remy , Tensen Cornelis P. , Mecucci Cristina , Macintyre Elizabeth , Leroux Dominique , Brambilla Elisabeth , Nguyen-Khac Florence , Luquet Isabelle , Penther Dominique , Bastard Christian , Jardin Fabrice , Lefebvre Christine , Garnache Francine , Callanan Mary B. 
Published: April 2016

Key Points
NR3C1 haploinsufficiency is found in patients with a plasmacytoid dendritic cell neoplasm characterized by very poor clinical outcome. Overexpression of lincRNA-3q is a consistent feature of malignant cells in these patients and can be abrogated by BET protein inhibition.
Structured feature selection using coordinate descent optimization
Authors: Ghalwash Mohamed F. , Cao Xi Hang , Stojkovic Ivan , Obradovic Zoran 
Published: April 2016

Abstract
Background
Existing feature selection methods typically do not consider prior knowledge in the form of structural relationships among features. In this study, the features are structured based on prior knowledge into groups. The problem addressed in this article is how to select one representative feature from each group such that the selected features are jointly discriminating the classes.
The problem is formulated as a binary constrained optimization and the combinatorial optimization is relaxed as a convex-concave problem, which is then transformed into a sequence of convex optimization problems so that the problem can be solved by any standard optimization algorithm. Moreover, a block coordinate gradient descent optimization algorithm is proposed for high dimensional feature selection, which in our experiments was four times faster than using a standard optimization algorithm.

Results
In order to test the effectiveness of the proposed formulation, we used microarray analysis as a case study, where genes with similar expressions or similar molecular functions were grouped together. In particular, the proposed block coordinate gradient descent feature selection method is evaluated on five benchmark microarray gene expression datasets and evidence is provided that the proposed method gives more accurate results than the state-of-the-art gene selection methods. Out of 25 experiments, the proposed method achieved the highest average AUC in 13 experiments while the other methods achieved higher average AUC in no more than 6 experiments.

Conclusion
A method is developed to select a feature from each group. When the features are grouped based on similarity in gene expression, we showed that the proposed algorithm is more accurate than state-of-the-art gene selection methods that are particularly developed to select highly discriminative and less redundant genes. In addition, the proposed method can exploit any grouping structure among features, while alternative methods are restricted to using similarity based grouping.
A review of the trends in Ghana’s power sector
Authors: Eshun Maame Esi , Amoako-Tuffour Joe 
Published: April 2016

Abstract
Power generation in Ghana has gone through a number of phases: starting with diesel generators and stand-alone electricity supply systems owned by industrial mines and factories, to the hydro phase following the construction of the Akosombo dam, and now to a thermal complement phase powered by gas and/or light crude oil. A power crisis has also become a perennial development challenge in Ghana, with increasing severity that threatens the country’s economic growth and transformation. The troubling rationing system, the slowdown in industrial activity, job and income losses, and disruptions in social life are telling reminders of what now seems a perennial drag on Ghana’s development agenda. While Ghana has committed itself to universal electricity access by 2020, the real challenge is the capacity to meet this goal and, most important, to ensure that supply is reliable and adequate. This paper outlines the state of current electricity demand and supply gap and the major impediments to resolving the supply bottlenecks and in managing demand, highlights institutional and regulatory constraints, and identifies some key issues that should be the focus of policy decision-making going forward.
Hyperpigmentation after surgery for a deep dermal burn of the dorsum of the hand: partial-thickness debridement followed by medium split-thickness skin grafting vs full-thickness debridement followed by thick split-thickness skin grafting
Authors: Kubota Yoshitaka , Mitsukawa Nobuyuki , Chuma Kumiko , Akita Shinsuke , Sasahara Yoshitaro , Rikihisa Naoaki , Satoh Kaneshige 
Published: April 2016

Abstract

Background
Early excision and skin grafting are commonly used to treat deep dermal burns (DDBs) of the dorsum of the hand. Partial-thickness debridement (PTD) is one of the most commonly used procedures for the excision of burned tissue of the dorsum of the hand. In contrast, full-thickness debridement (FTD) has also been reported. However, it is unclear whether PTD or FTD is better.

Methods
In this hospital-based retrospective study, we compared the outcomes of PTD followed by a medium split-thickness skin graft (STSG) with FTD followed by a thick STSG to treat a DDB of the dorsum of the hand in Japanese patients. To evaluate postoperative pigmentation of the skin graft, quantitative analyses were performed using the red, green, and blue (RGB) and the hue, saturation, and brightness (HSB) color spaces. We have organized the manuscript in a manner compliant with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement.

Results
Data from 11 patients were analyzed. Six hands (five patients) received grafts in the PTD group and eight hands (six patients) received grafts in the FTD group. Graft take was significantly better in the FTD group (median 98 %, interquartile range 95–99) than in the PTD group (median 90 %, interquartile range 85–90) (P &lt; 0.01). Quantitative skin color analyses in both the RGB and HSB color spaces showed that postoperative grafted skin was significantly darker than the adjacent control area in the PTD group, but not in the FTD group.

Conclusions
There is a possibility that FTD followed by a thick STSG is an option that can reduce the risk of hyperpigmentation after surgery for DDB of the dorsum of the hand in Japanese patients. Further investigation is needed to clarify whether the FTD or the thick STSG or both are the factor for the control of hyperpigmentation.
Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody
Authors: Yin Yongjun , Ren Xiaodi , Smith Craig , Guo Qianxu , Malabunga Maria , Guernah Ilhem , Zhang Yiwei , Shen Juqun , Sun Haijun , Chehab Nabil , Loizos Nick , Ludwig Dale L. , Ornitz David M. 
Published: April 2016

ABSTRACT
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed in 10% of primary resected non-small cell lung cancer (NSCLC) specimens. Furthermore, in a mouse model where FGF9 can be induced in lung epithelial cells, epithelial proliferation and ensuing tumorigenesis is dependent on FGFR3. To develop new customized therapies for cancers that are dependent on FGFR3 activation, we have used this mouse model to evaluate a human monoclonal antibody (D11) with specificity for the extracellular ligand-binding domain of FGFR3, that recognizes both human and mouse forms of the receptor. Here, we show that D11 effectively inhibits signaling through FGFR3 in vitro, inhibits the growth of FGFR3-dependent FGF9-induced lung adenocarcinoma in mice, and reduces tumor-associated morbidity. Given the potency of FGF9 in this mouse model and the absolute requirement for signaling through FGFR3, this study validates the D11 antibody as a potentially useful and effective reagent for treating human cancers or other pathologies that are dependent on activation of FGFR3.
DREAMTools: a Python package for scoring collaborative challenges
Authors: Cokelaer Thomas , Bansal Mukesh , Bare Christopher , Bilal Erhan , Bot Brian M. , Chaibub Neto Elias , Eduati Federica , de la Fuente Alberto , Gönen Mehmet , Hill Steven M. , Hoff Bruce , Karr Jonathan R. , Küffner Robert , Menden Michael P. , Meyer Pablo , Norel Raquel , Pratap Abhishek , Prill Robert J. , Weirauch Matthew T. , Costello James C. , Stolovitzky Gustavo , Saez-Rodriguez Julio 
Published: April 2016

DREAM challenges are community competitions designed to advance computational methods and address fundamental questions in system biology and translational medicine. Each challenge asks participants to develop and apply computational methods to either predict unobserved outcomes or to identify unknown model parameters given a set of training data. Computational methods are evaluated using an automated scoring metric, scores are posted to a public leaderboard, and methods are published to facilitate community discussions on how to build improved methods. By engaging participants from a wide range of science and engineering backgrounds, DREAM challenges can comparatively evaluate a wide range of statistical, machine learning, and biophysical methods. Here, we describe DREAMTools, a Python package for evaluating DREAM challenge scoring metrics. DREAMTools provides a command line interface that enables researchers to test new methods on past challenges, as well as a framework for scoring new challenges. As of March 2016, DREAMTools includes more than 80% of completed DREAM challenges. DREAMTools complements the data, metadata, and software tools available at the DREAM website http://dreamchallenges.org and on the Synapse platform at https://www.synapse.org.Availability: DREAMTools is a Python package. Releases and documentation are available at http://pypi.python.org/pypi/dreamtools. The source code is available at http://github.com/dreamtools/dreamtools.
DEMOGRAPHIC FACTOR OF MODERNIZATION OF MODERN RUSSIA
Authors: Меркулов  , Merkulov Pavel 
Published: April 2016

The author reveals the problem of interdependence of demographic dynamics of social and economic development of the country. The features of demographic modernization of modern Russian society are shown.
The demographic factor of modernization, considered both as quantitative and qualitative aspects, is the basis of innovative growth in Russia. In the first decade of the XXI century there were positive developments in the main indicators of the natural reproduction of population fertility and mortality. The author substantiated the tasks that would improve the human potential of the Russians, and linked them to the urgent need to change the paradigm of social policy.
Volatility of yields of government bonds among GIIPS countries during the sovereign debt crisis in the euro area
Authors: Heryan Tomas , Ziegelbauer Jan 
Published: April 2016

The aim of the paper is to estimate, how the volatility of yields of the Greek bonds affects yields’ volatilities of bonds in selected European countries during the period of the sovereign debt crisis in the euro area. We obtained data for 10-year bonds in a weekly frequency from January 2006 till the end of December 2014. To make a comparison of pre-crisis period, we firstly investigate a bond yields’ volatility before 15th September 2008, when U.S. Leman Brothers bankrupted and the global financial crisis had been reflected in full. However, the period of the global financial crisis could also negatively affect the development of government bonds. Therefore, the period after Leman Brothers’ bankruptcy has been excluded and our crisis period starts after 23rd April 2010, when Greece asked the IMF for financial help and the sovereign debt crisis had been reflected in full. Volatility models GARCH (1,1), IGARCH (1,1) and TARCH (1,1) were used as an estimation method. To examine the risk premium of all GIIPS economies (Greece, Ireland, Italy, Portugal and Spain), we also compared the whole investigation with the developments of each spread against the yields of German government bonds. Our results clearly proved not only big differences between pre-crisis and crisis period, but also differences in output with the bond yield spreads. It was concluded that there has been a higher impact of the Greek bond yields, as well as yield spreads volatility in 2010 and 2011, while it is on the lower level in pre-crisis period.
Research roundup: April 2016
Authors: Greener Mark 
Published: April 2016

In brief 1 in 20 children show food hypersensitivity; but just half of these express IgE Taking aspirin long-term protects against gastrointestinal cancers Pioglitazone reduces the risk of stroke, myocardial infarction and diabetes in patients with insulin resistance who recently experienced ischaemic cerebrovascular events Migraines seem to be linked to irritable bowel syndrome and ischemic stroke
Brunner’s gland hamartoma: a cause of the double-duct sign
Authors: Kostalas M , Jackson P , Karanjia N 
Published: April 2016

Introduction Brunner’s glands are submucosal glands found in the duodenum. Proliferation of these glands can lead to the formation of Brunner’s gland hamartomas (BGHs), which are uncommon, asymptomatic and usually found incidentally. They are predominantly benign lesions, but instances of malignant transformation have been reported. Case History We describe a rare case in which a periampullary lesion was causing biliary obstruction on a background of weight loss, and was associated with dilatation of the common bile duct and pancreatic duct on computed tomography and magnetic resonance imaging. Further investigation with endoscopic ultrasound and biopsy did not provide a definitive diagnosis. Given the symptoms and findings upon investigations, we proceeded to pylorus-preserving pancreatoduodenectomy. Conclusions This was a rare case in which BGH gave rise to biliary obstruction against a background of weight loss. Due to a high index of suspicion (weight loss and evidence of dilatation of the common bile duct and pancreatic duct), this procedure was justified because the consequences of a missed periampullary cancer far outweighed surgical risks.
What happens when we do not operate? Survival following conservative bowel cancer management
Authors: Bethune R , Sbaih M , Brosnan C , Arulampalam T 
Published: April 2016

Introduction While surgery is the cornerstone of bowel cancer treatment, it comes with significant risks. Among patients aged over 80 years, 30-day mortality is 13%–15%, and additionally 12% will not return home and go on to live in supportive care. The question for patients and clinicians is whether operative surgery benefits elderly, frail patients. Methods Multidisciplinary team outcomes between October 2010 and April 2012 were searched to conduct a retrospective analysis of patients with known localised colorectal cancer who did not undergo surgery due to being deemed unfit. Results Twenty six patients survived for more than a few weeks following surgery, of whom 20% survived for at least 36 months. The average life expectancy following diagnosis was 1 year and 176 days, with a mean age at diagnosis of 87 years (range 77–93 years). One patient survived for 3 years and 240 days after diagnosis. Conclusions Although surgeons are naturally focused on surgical outcomes, non-operative outcomes are equally as important for patients. Elderly, frail patients benefit less from surgery for bowel cancer and have higher risks than younger cohorts, and this needs to be carefully discussed when jointly making the decision whether or not to operate.
Social stratification in the social sharing network: Advertisement texts against to conservative bourgeoisie<p>Toplumsal paylaşım ağlarında sosyal tabakalaşma: Muhafazakâr burjuvaziye yönelik reklam metinleri
Authors: Sezgin Ayşe Aslı , Karabacak Zaliha İnci 
Published: April 2016

Making themselves felt in various areas from political and economic changes and transformations across the world to the practices of daily life, social networks have started building a virtual culture within the network environment. Today, great social changes are observed and, maybe, one of the most important factors of this change is technology. With the changes caused by the technological development, different perspectives, values and perceptions can create and relay their own contents via social networks. The conservative bourgeoisie which can consequently be evaluated within the scope of transformations, changes and consequently innovations and as a consequence of the social stratification is addressed in terms of its representation on social networks and within the scope of Weber's social stratification theory. While the social stratification on social networks is emphasized in this evaluation, the advertisement texts used on these networks are examined based on the characteristics of the conservative bourgeoisie from a sociological perspective. ÖzetDünya’da siyasi ve ekonomik değişim ve dönüşümlerin yaşanmasından, gündelik hayatın pratiklerine kadar birçok alanda etkisini hissedilir şekilde gösteren toplumsal paylaşım ağları, sanal ortamda sanal bir kültürün de inşasına başlamıştır. Sosyal anlamda büyük değişimlerin yaşandığı günümüzde bu değişimde belki de en önemli etkenlerden biri gelişen teknolojidir. Teknolojik gelişimin getirdiği değişimlerin etkisiyle farklı bakış açıları, değerler, algılar toplumsal paylaşım ağları vasıtasıyla kendi içeriklerini oluşturmakta ve bunu yansıtabilmektedir. Dönüşümler, değişimler ve nihayet yenilikler kapsamında ve sosyal tabakalaşmanın bir neticesi olarak değerlendirilebilecek muhafazakâr burjuvazi, bu çalışmada toplumsal paylaşım ağlarındaki temsili çerçevesinde ve Weber’in sosyal tabakalaşma kuramı kapsamında ele alınacaktır. Bu değerlendirmede toplumsal paylaşım ağlarındaki sosyal tabakalaşma vurgulanırken, özellikle bu ağlarda yer alan reklam metinleri sosyolojik perspektiften muhafazakâr burjuvazi hedef kitlesinin özellikleri dikkate alınarak içerik analizi yöntemiyle incelenecektir.
ВИКОРИСТАННЯ ПРОГРАМИ «SIMPLY TAGGING» ДЛЯ ПРОГНОЗУВАННЯ ГУСТОТИ ПТАХІВ У ГНІЗДОВИХ БІОТОПАХ
Authors: Matsyura О. V. , Matsyura М. V. , Zimaroyeva А. А. 
Published: April 2016

<p>For the analysis of long-term observations data on dynamics of bird populations the most suitable methods could be the stochastic processes. Abundance (density) of birds is calculated on the integrated area of studied habitats. Using the method of autocorrelation the correlogram of changes in number of birds drawn during the study period in all the area. After that, the calculation of the autocorrelation coefficients and partial autocorrelation are performed. The most appropriate model is the mixed autoregressive moving average (ARIMA). Ecological significance of autoregressive parameters is to display the frequency of changes in the number of birds in the seasonal and long-term aspects. The sliding average is one of the simplest methods, which allows reject the random fluctuations of the empirical regression line. Validation of the model could be conducted on truncated data series (10 years). The forecast is calculated for the next two years and compared with empirical data. Calculation of correlation coefficients between the real data and the forecast is performed using non-parametric Spearman correlation coefficient. The residual rows of selected models are estimated by residual correlogram. The constructed model can be used to analyze and forecast the number of birds in breeding biotopes.</p> <p><em>Keywords: analysis, density, indirect methods, birds, Simply Tagging.</em></p> <p> </p>
АГРЕГАТНАЯ СТРУКТУРА ТЕХНОЗЕМОВ НИКОПОЛЬСКОГО МАРГАНЦЕВО–РУДНОГО БАСЕЙНА
Authors: Zhukov A. V. , Zadorozhnaja G. A. , Ljadskaja I. V. 
Published: April 2016

<p>The profile distribution of industrial soil’s aggregate structure in the experimental polygon of the Nikopol manganese ore basin has been studied. The soil type and layer depth were the most powerful factors of formation of aggregate structure of industrial soils. The distinctive abilities of aggregate structure dynamics for differentiation of industrial soil type according to their profiles have been defined. The variability of indices of fractions between 10 and 0.25 mm was depended on the industrial soil type and to a lesser degree from the profile allocation. Percentage of structural aggregates with a size 3-1 and 1-0,5 mm were typical for certain levels of a profile also is similar in different industrial soils. There was certain specificity of profile allocation of fractions with a size 10-7 and 7-5 mm, distinguishing industrial soil type from each other.</p> <p><em>Keywords</em><em>: </em><em>aggregate structure, industrial soils,</em><em> </em><em>recultivation</em><em>.</em></p>
ЗОО- И ФИТОИНДИКАЦИЯ РОЛИ АВТОТРОФНОЙ И ГЕТЕРОТРОФНОЙ КОНСОРЦИЙ В ОРГАНИЗАЦИИ БИОГЕОЦЕНОЗА
Authors: Kunakh O. N. , Tryfanova M. V. , Ganzha D. S. 
Published: April 2016

<p>The main results of ecomorfology structure of soil mesofauna in the adjacent area of Dneprovsko-Orylskiy Natural Reserve (Ireland Pogorily ore Dyka Kosa) have been presented by the methods of OMI- and RLQ – analysis. The components of variability of the soil animal world (in colony of <em>Ardea</em><em> </em><em>cinerea</em> L.), which is conditioned by auto- and heterotrophic consortia and also by influence of edaphically properties of biogeocoenoses were determined. Also we registered the high level and dynamics of mineral feed and presence of nitrogen in the soil. The results of description of taxonomic and ecological diversity in association of mesopedobionts were presented. We proved that the coenomorphic type of the animals was bog-forest. On the basic of joint measuring of edaphically descriptions and features of fauna structure we estimated the properties of ecological niche of soil mesofauna.</p> <p><em>Key words:</em><em> estimation of phytoindication, soil mesofauna, ecomorphic analysis, consortia, bird colonies.</em></p>
Impact of the Aggressive Scaling on the Performance of FinFETs: the Role of a Single Dopant in the Channel
Authors: Aldegunde Manuel , Martinez Antonio 
Published: April 2016

ABSTRACTNon-equilibrium Green’s functions (NEGF) simulations are carried out to determine the impact of an unintentional dopant in the middle of the channel of a FinFET. We consider two different geometries scaled according to the ITRS and two different types of dopants, donors and acceptors. We show that there is a degradation of the subthreshold characteristics with the scaling of the smooth device and also a stronger impact of the stray dopants in the middle of the channel, with variations up to 32% in the current in on-state conditions.