bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDTA influences reactivity of isolated aorta from hypercholesterolemic rabbits
Authors: Simon B. C. , Cohen R. A. 
Published: December 2017

Pages H1606–H1610: B. C. Simon and R. A. Cohen. “EDTA influences reactivity of isolated aorta from hypercholesterolemic rabbits.” Page H1608: Figures 1 and 2 should read as the following. (See PDF)
Characterization of E-selectin expression in vivo with use of a radiolabeled monoclonal antibody
Authors: Keelan E. T. M. , Licence S. T. , Peters A. M. , Binns R. M. , Haskard D. O. 
Published: December 2017

We have studied endothelial luminal surface expression of E-selectin in vivo in the pig. Intravenous interleukin-1 (IL-1, 5-μg/kg bolus ± 50-ng·kg-1·min-1 infusion for 2 h) induced E-selectin expression in many organs, as shown by immunostaining and selective clearance of intravenous 111In- or 99mTc-labeled anti-E-selectin monoclonal antibody MAb 1.2B6) compared with radiolabeled immunoglobulin G1 control. Specific clearance of MAb 1.2B6 commenced 30­45 min after intravenous IL-1. Skin sites injected with IL-1, tumor necrosis factor, phytohemagglutinin, or phorbol myristate acetate at various times (45 min­24 h) before exsanguination showed specific accumulation of MAb 1.2B6 when 99mTc-MAb 1.2B6 and 111In-control immunoglobulin G1 were injected intravenously 10 min before exsanguination. This was maximal in 2-h IL-1 and tumor necrosis factor lesions and after 9 h in phytohemagglutinin and phorbol myristate acetate lesions. This novel approach has allowed us to quantify changes in vascular luminal expression of E-selectin in models of inflammation involving systemic and localized endothelial cell activation and has considerable potential for analyzing these changes in relation to leukocyte traffic and other manifestations of inflammatory responses in vivo. endothelium; inflammation; radioimmunodetection Submitted on February 25, 1993 Accepted on June 23, 1993
Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte
Authors: Nordin Charles 
Published: December 2017

Pages H2117–H2136: Nordin, Charles. “Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte.” Figure 13: Units of time in Fig. 13B are seconds (not milliseconds). The output for concentration, using the equations of the appendix, is in units of 10−3 mol/l (millimolar). Equation A29 should read (See PDF) Equations A30a and A31a should read (See PDF) Note: All errors in equations, except for the term with asterisk in Eq. A31a and removal of the term (0.1 x iCa) from Eq. A30a, were made in transcribing the computer program to the set of printed equations and therefore do not involve any simulations of the paper. The other changes are refinements of the program that slightly reduce the rise in [Na+]myo and fall in [K+]myo with increasing stimulation rate (Fig. 5A) but do not affect other aspects of the behavior of the model in any significant way.
Action of Physostigmine (Eserine) Sulfate on Peripheral Nerve
Authors: Wright Ernest B. 
Published: December 2017

The effect of eserine (physostigmine) sulfate on frog and rabbit nerve has been studied. Concentrations ranging from 0.005–0.08 m caused: a) a reversible block of conduction in from 50–120 minutes in frog nerve, 20–40 minutes in rabbit nerve; b) the threshold (rheobase) to rise to three times normal value in frog nerve and up to five times normal value in rabbit nerve; c) No change in the value of the excitability constant k; d) The refractory periods to be greatly lengthened. Absolute periods of 10 msec., relative periods of 50 msec were obtained; e) a 60% reduction in the conduction velocity; f) a slight depolarization of less than 2 mv. A constant anodal voltage applied along 3 cm length of nerve partially relieves the eserine blocking action, cathodal voltage enhances the drug action. Nerve conduction is blocked much quicker with continuous stimulation, due to the lengthening of the refractory period. Following a brief interruption of continuous stimulation, a second or less, an action potential can be elicited again. This spike is almost identical with the action potential of a nonstimulated nerve subjected to eserine for the same period of time. The blocking action cannot be due to acetylcholine accumulation by the anticholinesterase activity of eserine, but rather is due to the inactivation of the sodium mechanism by the drug. Eserinized nerve loses some sodium quickly, large amounts of potassium more slowly.
Effect of external potassium concentrations, insulin and lactate on frog muscle potassium and respiratory rate
Authors: Smillie L. B. , Manery J. F. 
Published: December 2017

L. B. Smillie and J. F. Manery, "Effect of external potassium concentrations, insulin and lactate on frog muscle potassium and respiratory rate." Page 69: Table 1, Section 3, Insulin effect in the presence of lactate (May, June and July), column 3 (Exptl.) should read RIL for all solutions. Page 70: 1st column, 4th paragraph, 2nd sentence should read: A marked depression of the oxygen consumption. ... Page 71: 1st column, 3rd paragraph, 14th line should read: ... Ringer-lactate at the 5th and 6th hours being 136.9 and that in Ringer-insulin-lactate being 81.8 cu mm/gm/hr. Page 72: 1st column, 1st paragraph, 7th line should read: ... lactate when the metabolic changes invoked by high potassium were in operation. Page 73: 1st column, 2nd paragraph, 15th line should read: ... muscle and fluid analyses are presented in column 7. Page 73: 2nd column, 3rd paragraph, 6th line should read: That the depression of the potassium movement is specifically related to insulin and is unrelated to lactate is again implied. ... Page 74: 1st column, 1st paragraph, 8th line should read: ... the amounts of potassium taken from the medium. ... Page 76: 2nd column, 3rd paragraph, 9th line should read: ... that phosphocreatine began to be hydrolyzed. ... Page 77: Reference 1 should read: Manery, J. F., L. B. Smillie and K. E. Toye. J. Cell & Comp. Physiol. 44:336, 1954.
Effects of intense exercise training on plasma catecholamines in coronary patients
Authors: Ehsani Ali A. , Heath Gregory W. , Martin Wade H. , Hagberg James M. , Holloszy John O. 
Published: December 2017

This paper reports the effect of 12 mo of intense endurance exercise training on the plasma catecholamine response to exercise in 11 male patients [aged 50 ± 8 yr (mean ± SD)] with coronary artery disease. A substantial adaptation to training was attained as evidenced by a 42% increase in maximum O2uptake capacity. At rest, heart rate was lower after training, but resting blood pressure and plasma catecholamines were unchanged. At the same absolute work rate, plasma norepinephrine and epinephrine levels, rate pressure product, and ischemic S-T segment depression were all significantly lower aftertraining. A higher plasma norepinephrine level was attained at maximal exercise after training (2,049± 654 before vs. 3,408 ± 1,454 pg/ml after, P < 0.025); this was associated with a higher systolic blood pressure (175 ± 25 before vs. 188 ± 22 mmHg after, P < 0.025) and a higher rate-pressure product (25.3 x 103 ± 4.5 x 103 before vs. 27.6 x 103 ± 5.2 x 103 after, P < 0.025). Despite the higher plasma norepinephrine level and rate pressure product, S-T segment depression at maximal exercise was unchanged. These findings suggest that some patients with coronary arterial disease can attain a higher myocardial O2 requirement, without electrocardiographic evidence of increased ischemia, after prolonged strenuous exercise training. myocardial infarction; coronary arterial disease Submitted on July 5, 1983 Submitted on July 5, 1983
A memória da infância e a formação da nação emergente em Luís Cardoso
Authors: Queiroga Mariene de Fátima Cordeiro , Paulino Vicente 
Published: December 2017

Esse trabalho aborda a personagem da trilogia cardosiana, por hipótese, o próprio autor-narrador, como sujeito principal da sua obra e suas narrativas como a metáfora da formação do Estado nação Timor-Leste. O romancista é um sujeito que na expressão de Homi Bhabha: aquele “que representa uma diferença ‘interior’, um sujeito que habita a borda de uma realidade ‘intervalar’. E a inscrição dessa existência fronteiriça consiste numa quietude do tempo e uma estranheza de enquadramento que ‘cria a imagem discursiva na encruzilhada entre história e literatura” (Bhabha, 1998:35).
ABO blood group A transferases catalyze the biosynthesis of FORS blood group FORS1 antigen upon deletion of exon 3 or 4
Authors: Yamamoto Miyako , Cid Emili , Yamamoto Fumiichiro 
Published: December 2017

Key PointsABO blood group A transferases possess intrinsic FS activity upon deletion of exon 3 or 4 of A transferase messenger RNAs. Cointroduction of exon 3 or 4 deletion and GlyGlyAla substitution synergistically confers human A transferases with strong FS activity.
Root-originating dentinal defects: methodological aspects and clinical relevance
Authors: Tawil Peter Zahi , Arnarsdottir Elisa Kristin , Coelho Marcelo Santos 
Published: December 2017

Abstract
It was in the 1980s when the association between root-filling procedures and dentinal microcracks was made. Nowadays, root-originating microcracks, also known as dentinal defects, are recognized as a possible precursor that is part of the longitudinal process of root-originating fractures. The presence of dentinal defects has been shown to significantly decrease the outcome through a periapical microsurgery model. Several in vitro articles have been published in the past years in regards to dentinal defects, but most of them have serious methodology concerns that will be discussed in this review.
A total grasp of the development and the role dentinal defects play in endodontics is crucial to the specialty. This review aims to discuss dentinal defects and their causative factors and the research models that have been used and their clinical significance. Through a comprehensive critical review of the literature, this article will express the need for further in vivo clinical research and better ex vivo methods that can replicate the clinical setting to answer several remaining questions about the development of and the role dentinal defects play in endodontics.
Prescribing an App? Oncology Providers’ Views on Mobile Health Apps for Cancer Care
Authors: Berkowitz Callie M. , Zullig Leah L. , Koontz Bridget F. , Smith Sophia K. 
Published: December 2017

Introduction Although there are over 500 mobile health (mHealth) applications (apps) available for download in the field of oncology, little research has addressed their acceptability among health care providers. In addition, the providers’ perspectives regarding patient app use has been largely unexamined. We conducted a qualitative study to explore opportunities and barriers for mHealth app use for oncology care. Methods We developed a structured interview guide focusing on acceptability, appropriateness, feasibility, and sustainability of the use of apps in cancer care. We interviewed 15 oncology providers about their attitudes and preferences. De-identified audio recordings were transcribed and coded for emerging themes. Results Providers interviewed included physicians (n = 8) and advanced practice (n = 3) and supportive services (n = 4) providers who care for a wide range of cancer types; ages ranged from 32 to 68 years. Interviews lasted approximately 30 minutes. Oncology providers reported limited exposure to mHealth apps in patient care, but were generally open to recommending or prescribing apps in the future. Key themes included opportunities for mobile app use (including general health promotion, tracking symptoms, and engaging patients) and barriers to implementation (including access to technology, responsibility, workflow, and the source of the app itself). Conclusion Our results show openness among oncology providers to using mHealth technology as part of patient care, but concerns regarding implementation. Designing acceptable apps may be challenging and require involvement of key stakeholders, partnering with trustworthy institutions, and outcome-based research.
Doutrina Chevron no Brasil: uma alternativa à insegurança jurídica
Authors: Silveira Andre Bueno da 
Published: December 2017

Chevron Doctrine in Brazil: an alternative to legal uncertainty Analisa-se neste artigo a possibilidade de se utilizar a Doutrina Chevron como alternativa para o atual problema de insegurança jurídica no direito administrativo no Brasil. Inicia-se o artigo com a evolução do controle judicial sobre o mérito do ato administrativo. Em seguida, aborda-se o problema central da análise: a crise de insegurança jurídica decorrente da amplificação da legalidade, particularmente sentida quando o Poder Judiciário revê decisões proferidas após o devido processo administrativo. Em seguida, passa-se à apresentação de uma proposta de solução com base no direito comparado: a utilização da Doutrina Chevron. Faz-se uma ponderação sobre a necessidade de fortalecimento das instituições no Brasil como condição para a adoção da Doutrina Chevron. Conclui-se que essa doutrina pode ser uma solução interessante a longo prazo para o problema da insegurança jurídica no Brasil. In this article I assess the possibility of using the Chevron doctrine as an alternative to the current problem of legal uncertainty in the administrative law in Brazil. I begin with the evolution of judicial review of the merit of administrative decisions. Then, I present the main problem to be analyzed: the crisis of legal uncertainty caused by the enlargement of the notion of legality, particularly felt when the Judiciary reviews decisions enacted after the due administrative process. After that, I present a solution proposal based on comparative law: the use of the Chevron doctrine. I consider the need of strengthening the public institutions in Brazil as a condition to the adoption of the Chevron doctrine. In conclusion, I argue that this doctrine can be an interesting solution in the long term to the problem of legal uncertainty in Brazil.
Training Aspiring Entrepreneurs to Pitch Experienced Investors: Evidence from a Field Experiment in the United States
Authors: Clingingsmith David , Shane Scott 
Published: December 2017

Accredited investors finance more than 75,000 U.S. startups annually. We explain how training aspiring entrepreneurs to pitch their new business ideas to these investors affects their odds of continued funding discussions. We model accredited investors’ decision to continue investigation as a real option whose value is a function of their experience and the information contained in the entrepreneurs’ pitches. We derive four hypotheses from the model, which we test through a field experiment that randomly assigns pitch training at four elevator pitch competitions. The data support all four hypotheses and are inconsistent with alternative explanations. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2882 . This paper was accepted by Ashish Arora, entrepreneurship and innovation.
An improved structural model of the human iron exporter ferroportin. Insight into the role of pathogenic mutations in hereditary hemochromatosis type 4
Authors: Tortosa Valentina , Bonaccorsi di Patti Maria Carmela , Brandi Valentina , Musci Giovanni , Polticelli Fabio 
Published: December 2017

Abstract
Ferroportin (Fpn) is a membrane protein representing the major cellular iron exporter, essential for metal translocation from cells into plasma. Despite its pivotal role in human iron homeostasis, many questions on Fpn structure and biology remain unanswered. In this work, we present two novel and more reliable structural models of human Fpn (hFpn; inward-facing and outward-facing conformations) obtained using as templates the recently solved crystal structures of a bacterial homologue of hFpn, Bdellovibrio bacteriovorus Fpn. In the absence of an experimentally solved structure of hFpn, the structural predictions described here allow to analyze the role of pathogenic mutations in the Fpn-linked hereditary hemochromatosis disease and represent a valuable alternative for reliable structure-based functional studies on this human iron exporter.
UWB Filtering Power Divider with Two Narrow Notch-bands and Wide Stop-band
Authors: Wei Feng , Wang Xin-Yi , Zou Xin Tong , Shi Xiao Wei 
Published: December 2017

AbstractA compact filtering ultra-wideband (UWB) microstrip power divider (PD) with two sharply rejected notch-bands and wide stopband is analyzed and designed in this paper. The proposed UWB PD is based on a conventional Wilkinson power divider, while two stub loaded resonators (SLRs) are coupled into two symmetrical output ports to achieve a bandpass filtering response. The simplified composite right/left-handed (SCRLH) resonators are employed to generate the dual notched bands. Defected ground structure (DGS) is introduced to improve the passband performance. Good insertion/return losses, isolation and notch-band rejection are achieved as demonstrated in both simulation and experiment.
Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives
Authors: Dofe Vidya S. , Sarkate Aniket P. , Shaikh Zarina M. , Gill Charansingh H. 
Published: December 2017

Abstract
New tetrazole-based pyrazole and pyrimidine derivatives were synthesized by an ultrasound irradiation method. All compounds were characterized by infrared spectroscopy (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectrometry (MS) and elemental analysis and assessed in vitro for their efficacy as antimicrobial agents against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus niger). Compounds 8a, 8e, 9a, 9b and 9e show potent activity against the tested strains compared to the reference drugs chloramphenicol and clotrimazole.
Influence of timber moisture content on wave time-of-flight and longitudinal natural frequency in coniferous species for different instruments
Authors: Llana Daniel F. , Íñiguez-González Guillermo , Martínez Roberto D. , Arriaga Francisco 
Published: December 2017

AbstractNon-destructive techniques (NDTs) are well suited for rapid estimation of timber properties, but NDT results are affected by several factors, the most important of which is the moisture content (MC) of wood. Much of the research in this context was limited to ultrasound measurement of a few wood species, mainly to Norway spruce. The present paper investigates the MC influence on the NDT results obtained by instruments based on ultrasound (two devices), impact stress waves (one device) and longitudinal vibrations (two devices). A hundred large cross-section specimens of four timber species were tested, namely: radiata pine, Scots pine, Salzmann pine and maritime pine. The influence of MC on velocity was found to be stronger below the fiber saturation point (FSP) than above FSP. MC adjustment factors below FSP are proposed for these wood species.
Simulation and Analysis of Flow Field in Sludge Anaerobic Digestion Reactor based on Computational Fluid Dynamics
Authors: Cao Xiuqin , Jiang Kun , Ding Hao , Yang Ping , Zhao Zhendong , Xu Guoqing 
Published: December 2017

Abstract
Because of the complexity of flow and the opacity of sludge, usually we can’t gain a precise and comprehensive sight of sludge flow type and its associated flow characteristics in the anaerobic digestion (AD) reactor. In the present study, we focused on the sludge rheological properties as well as the flow behavior in the digester. The viscosity decreased with the increase of shear rate, and sludge as a kind of pseudo-plastic fluid was proved. Based on computational fluid dynamics (CFD), taking sludge rheological index and rotational speed into consideration, then the flow field distribution in the digester was obtained. The fluid velocity raised with increase in rotational speed, moreover, fluid near blades had higher velocity while it was almost stagnant in the areas near reactor bottom and top as well as reactor wall and stirring shaft. The effect of rheological index on improving the velocity of fluid farther from impeller exceeded the influence on fluid at the impeller installation height. Regarding dead zone fraction as an indicator of the mixing effect, it was recommended that the suitable rotational speed for AD of 96 % moisture content sludge is 40 r/min. Finally, the reactor performance was optimized respectively from impeller form and reactor configuration, the results showed that both combined impellers and oval reactor can reduce dead zone volumes and produce a better mixing effect.
Amla (Emblica officinalis) improves hepatic and renal oxidative stress and the inflammatory response in hypothyroid female wistar rats fed with a high-fat diet
Authors: Muthu P. Rajaa , Bobby Zachariah , Sankar P. , Vickneshwaran V. , Jacob Sajini Elizabeth 
Published: December 2017

Abstract

Background:
We investigated the protective effects of amla (Emblica officinalis) on the pathogenesis of oxidative stress (OS) and inflammatory response in hypothyroid rats fed with a high-fat diet (HFD) as an experimental model of hypothyroidism (HT) with obesity.

Methods:
A total of 80 female wistar rats (5-months-old) were divided into eight different groups. Propylthiouracil (PTU) and HFD were used to induce the experimental HT and obesity, respectively. The euthyroid and hypothyroid rats were fed either normal chow or HFD with and without amla extract (AE, 100 mg/kg bw/day) for 6 weeks. The blood and tissues, liver and kidney OS and inflammatory parameters were studied using appropriate biochemical and molecular techniques.

Results:
PTU and HFD per se caused OS and inflammatory response as evidenced by increased plasma MDA, TNF-α, CRP and GPx in association with decreased levels of TAS and reduced glutathione (GSH). The proteomic analysis revealed that the expressions of pERK, pP38, TNF-α, IL6, COX2 and NOX-4 were up-regulated in the liver and kidney of these rats. In addition, all these metabolic derangements were further augmented when HT was followed by the addition of HFD. This suggested that there was a synergism between HT and the intake of HFD on the development of OS and inflammatory response.

Conclusions:
The treatment with amla fruit extract significantly restored the redox imbalance and inflammatory signaling and ameliorated OS and inflammatory response, suggesting the use of this natural compound as an alternative remedy or adjuvant for the management of metabolic complications concomitant with HT.
WHO 2006 Child Growth Standards overestimate short stature and underestimate overweight in Japanese children
Authors: Inokuchi Mikako , Matsuo Nobutake , Takayama John I. , Hasegawa Tomonobu 
Published: December 2017

AbstractBackground:It is unclear whether the World Health Organization (WHO) 2006 Child Growth Standards are applicable to East Asian populations. We investigated the applicability of the WHO standards of length/height and weight to a cohort representing middle-class children in Japan.Methods:A cohort of children aged 0–5 years (3430 boys, 3025 girls) in the Tokyo Child Care Center Survey consecutively recruited from 2007 to 2013 were studied. Age- and sex-specific z-scores of length/height, weight and weight for length/height were calculated relative to either the WHO standards or the Japanese 2000 Growth References (nationally representative cross sectional survey data).Results:Compared with the WHO standards, Japanese children at birth, 1, 3, 5 years were shorter (length/height standard deviation score [SDS] −0.26, −0.82, −0.81, −0.63 for boys, and −0.15, −0.67, −0.84, −0.62 for girls, respectively) and lighter (weight SDS −0.62, −0.36, −0.34, −0.42 for boys and −0.60, −0.17, −0.29, −0.43 for girls, respectively). Weight for length/height showed smaller differences at various length/height points (SDS −0.05 to 0.15 for boys, 0.01 to 0.29 for girls, respectively).Conclusions:Adoption of the WHO standards would substantially alter the prevalence of short stature, underweight and overweight in Japanese children 0–5 years of age. These findings advocate the use of the national references in Japan.