bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between TyG index and hypertension in middle-aged and elderly Chinese patients: data from CHALRS
Authors: Xie Zhijie , Lv Xuan , Ma Yijun , Dai Shanshan , Zhu Suijun , Wang Jun 
Published: September 2024

Abstract

Background
The TyG index is thought to be a trustworthy substitute indicator of insulin resistance. Increasing research evidence shows the correlation between TyG and various cardiovascular and cerebrovascular diseases and adverse prognosis. However, the effect of diabetes on the connection between TyG and hypertension has not been extensively studied. In order to identify high-risk individuals, our research aimed to investigate the potential relationship between the TyG index and the risk of hypertension in middle-aged and elderly Chinese individuals.
Methods
This study analyzed and collected information of the middle-aged and elderly population from the 2015 China Health and Retirement Longitudinal Study (CHARLS) database, and three groups were created based on the tertiles of TyG. First, the clinical characteristics of patients in different groups were analyzed univariately, and logistic regression analysis and RCS model were utilized to further clarify the relationship between the TyG index and hypertension. Finally, subgroup analysis was performed to distinguish the effects of different baseline characteristics on the connection between TyG and hypertension.
Results
9695 patients in all were enrolled, including 4548 males (46.9%) and 5147 females (53.1%). The incidence of hypertension in all patients was 33.7%. As displayed in Table 1, as the TyG index rises, the incidence of Diabetes, Heart disease, and Stroke in patients increased accordingly. Similarly, in terms of laboratory indicators, White blood cell, Platelets, Triglycerides, Uricacid, and Hbg increased with the rises of TyG; while the incidence of lung diseases, BUN, and HDL levels showed a downward trend. The RCS model showed that there was a nonlinear certain correlation between TyG and hypertension (p value < 0.001, nonlinear p = 0.008);Subgroup analysis showed that different baseline characteristics may influence the association between TyG and hypertension risk.
Conclusion
Our study's findings demonstrate a substantial correlation between TyG index and hypertension, showing a positive correlation in both adjusted and unadjusted logistic regression models, which may help identify individuals at risk for hypertension and have great potential through early improvement of blood pressure management. It has great potential to reduce the occurrence related to cardiovascular and cerebrovascular disorders.
Factors influencing implementation of health-promoting interventions at workplaces: A scoping review
Authors: Bhandari Aliza K C , Lwin Kaung Suu , Nguyen Phuong The , Htay Zin Wai , Shrestha Drishti , Saito Junko , Yaguchi-Saito Akiko , Ota Erika , Shimazu Taichi 
Published: September 2024

Abstract

Background:Health promotion interventions in the workplace are effective in improving employee health. However, many interventions are temporary and cannot be sustained, and a comprehensive understanding of the factors influencing their implementation is limited. Therefore, this scoping review aimed to identify the barriers and facilitators influencing the implementation of health promotion interventions in the workplace using the implementation framework.Methods:We searched PubMed, Web of Science, and Scopus from January 1986 to August 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Consistent with the Arksey and O’Malley framework, two independent reviewers reviewed the titles and abstracts for its eligibility followed by full-text screening using a data extraction form. A narrative summary of the barriers and facilitators identified from the included articles was then synthesized and categorized into the Consolidated Framework of Implementation Research (CFIR). The barriers and facilitators identified were stratified according to implementation outcomes.Results:Ofthe 38,384 articles identified, 610 articles wereeligible for the full-text screening, and 53 articles were included in the final analysis. Over 80% of the studies applied a qualitative or mixed-methods approach, and the most common topics of the interventions were reducing physical inactivity and promoting exercise (36%); and over 60% of studies targeted interventions in medium- to large- size organizations. Most of the factors were identified in the inner setting domain of the CFIR. Evidence strength and quality and leadership engagement were the predominant facilitators whereas structural characteristics, relative priority, and available resources were the most identified predominant barriers to the implementation of a workplace health promotion interventions.Conclusion:The barriers and facilitators identified in this study can be used to implement a process to develop a strategy that targets the identified determinants to improve workplace health promotion interventions and their implementation.
The Effect of Grazing Intensity on Properties of Mountain Steppe Pasture Vegetation and Soils
Authors: Sargsyan Tatevik , Babayan Gayane , Daveyan Harutyun , Navasardyan Marine 
Published: September 2024

Abstract

Purpose
Delivering sustainable management of mountain pasturelands with steppe vegetation is a concern to many nations including Armenia. Yet, to date, no unambiguous answer has been generated about the limiting impact domestic animal grazing has on the ecological status of such pastures. This research was designed to study the effect of different grazing management strategies (free grazing, reduced grazing, no grazing) on pastureland productivity including below-ground biomass and biodiversity, nutrient content of plants and soils.
Methods
ANOVA (Тukey’s test), Pearson correlation coefficient and the Redundancy analysis (RDA) was employed.
Results
The studies have indicated that livestock grazing has a strong impact upon biomass and diversity of plant groups., and the nutritive value of forages. Both below-ground biomass and root-to-shoot ratio are less dependen on the management strategy and increase the reduced grazing and free grazing sites. The effect of grazing on the nutrient contents of soils and vegetation is less pronounced; as a result of trampling the bulk density of soil and the contents of nitrogen, phosphorus, and potassium in above-ground and below-ground biomass increase.
Conclusions
The conducted studies and outcomes of grazing-imitation models allows us to conclude that regulation of grazing intensity and grazing regime in the ecosystems of mountain pasturelands are an effective approach to maintain and increase the capacity of natural fodder resources. The research results have already been used to develop measures to preserve the studied ecosystems.
The relationship between duration, bleeding volume, and activity for women in the progress of drug abortion: a cross-sectional study.
Authors: Wu wenbo , wang Liyan , wan wenjuan , yuan waixiang , zhu xiangfei , jiang qianqian , gao yun , cheng wei , Zheng Yuehui , Du Yanhong 
Published: September 2024

Abstract

Background: To investigate the influential factors associated with abortion time, bleeding volume, pain scores, and anxiety during the progress of drug abortion (DA).
Methods：Participants were randomly assigned to: (Ⅰ) The control group was given routine DA education and nursing, and the activity of subjects was not increased.（Ⅱ） The experimental group as same as the control, but appropriately increased their activity time.
Results: The mean age was 32.14±0.26 years. Advanced age exhibited positive correlation with abortion duration (rs=0.0102, P<0.05), but a negative association with pain scores (rs=-0.178, P<0.001). Dysmenorrhea emerged as a risk factor for prolonged abortion duration (rs=-0.097, P<0.05), but increase pain scores (rs=0.106, P<0.05) and anxiety levels (rs=0.119, P<0.05). Furthermore, history of cesarean section exhibited a positive influence on pain relief (rs=-0.226, P<0.001) and reduction in anxiety (rs=-0.129, P<0.001) during DA.
Conclusions: Women who have a history of vaginal delivery have earlier ovulation time than those who have not given birth, and women who have more activities have earlier ovulation time than those who have less activities under the same conditions;
Mountains as key areas for Carnivore Connectivity in Neotropical Grasslands
Authors: Aranguren María Florencia , Simoy María Verónica , Pizzarello María Gimena , Trofino-Falasco Clara , Velasco Melina Alicia , Leber Virginia , Moss Daniella Franzoia , Dopazo Judit , Berkunsky Igor 
Published: September 2024

Abstract

Habitat loss and fragmentation threaten biodiversity, particularly for carnivores whose dispersion and population viability are compromised by reduced available habitat and anthropic elements in the landscape, such as roads and crops. The world's grasslands have experienced considerable degradation and replacement by crops and are currently limited to natural patches scattered throughout the region. In Argentina, the last remaining grassland remnants that persist are associated within the Pampean mountain systems, which act as crucial refuges for the species that inhabit them in the region. Our objectives were to identify and map priority sites and areas that can act as ecological corridors between highland grassland patches of high conservation priority. We performed connectivity analyses using Least-cost Path Models and Circuit Theory. To do this, we generated habitat suitability models by combining environmental and anthropic variables, from which resistance surfaces were generated. We highlight areas of high habitat suitability for carnivores in the Pampas ecoregion, with particular emphasis on highland grassland. We identified potential corridors and least-cost paths for five carnivore species, obtaining multi-species corridors which highlight the importance of landscape connectivity for maintaining healthy populations. Centrality analyses revealed crucial grassland remnants and valuable corridors. These findings address the challenges associated with habitat fragmentation in the Pampas ecoregion and provide guidelines for future research and carnivore conservation actions.
Comprehensive Insights into Cnidarian Phylogenetics: cox3-Based Phylogeny, Mitochondrial Genome Variability, Introns, and Gene Rearrangements
Authors: Gao Ying , Kong Lingming 
Published: September 2024

Abstract

Cnidarians, an ecologically and culturally significant group, possess mitochondrial genomes that exhibit several features deviating from conventional textbook descriptions. In this study, we analyzed mitochondrial genomes across various cnidarian orders, revealing significant variation in gene rearrangement patterns. Notably, we found that Anthozoa exhibits highly variable gene arrangements despite slow evolutionary rates, while Hydrozoa demonstrates relatively high levels of gene rearrangement coupled with faster molecular evolution. Our analysis of the cytochrome c oxidase subunit III (cox3) gene provides new insights into cnidarian phylogeny, supporting the monophyly of both Anthozoa and Medusozoa, which aligns more closely with nuclear data and the currently accepted taxonomic scheme. Within Medusozoa, our cox3-based phylogenetic tree reveals strong support for monophyly at the class level. Our reconstruction also suggests a novel topology wherein Staurozoa, Hydrozoa, and Scyphozoa form a sister group to Cubozoa. This finding is particularly significant given the frequent inconsistencies observed in previous mitochondrial gene studies. The cox3 gene's predominant distribution on the heavy(+) strand and limited intron presence in most cnidarian species potentially reduces the impact of strand bias on phylogenetic signal, making it a valuable marker for phylogenetic reconstruction. However, our study also highlights the challenges inherent in using mitochondrial genes for deep phylogenetic reconstructions within Cnidaria. We observed incongruences between nuclear and mitochondrial phylogenies, as well as conflicts among different mitochondrial gene-based studies. These discrepancies underscore the complex nature of cnidarian evolution and the potential limitations of relying on a single type of genetic marker.
Scrutinization of hybrid nanofluid flow over a stretching/shrinking sheet with waste discharge concentration and chemical reaction
Authors: Mishra Ashish 
Published: September 2024

Abstract

This study examines the hydrothermal characteristics of hybrid nanofluid flow over a sheet in the presence of thermal radiation, chemical reaction, and waste discharge concentration to develop effective waste treatment and pollution control methods. The partial differential equations (PDEs) governing the conservation of mass, momentum, energy, and concentration, which are nonlinear, are transformed into ordinary differential equations (ODEs) using similarity transformations. The next stage in the process is to solve these ordinary differential equations (ODEs) using the bvp4c technique available in MATLAB. The study thoroughly explores several nondimensional parameters including suction/blowing, Darcy number, stretching/shrinking parameter, local pollutant external source parameter, and chemical reaction parameter, visually illustrating their impacts on flow patterns, thermal distribution, and concentration profiles. The scrutiny focuses on key engineering parameters such as skin friction coefficient, heat transfer rate, and mass transfer rate, supported by tabular data that enhances the quantitative evaluation of these parameters. It is found that the velocity of hybrid nanofluid upsurges with the increment in the stretching/shrinking parameter and Darcy number. Also, results obtained reveal that the concentration profiles experience an upward shift with an increase in unsteadiness parameter and local pollutant external source parameter.
Differences on the count of blood cells in pre-chemotherapy and post chemotherapy of patient with cancer in northern Ethiopia 2022, a longitudinal study
Authors: Kassie Tadele Derbew , Yimenu Bayu Wondimneh , Temesgen Gelagay Baye , Shimelash Rahel Asres , Abneh Ayisheshim Asnake 
Published: September 2024

Abstract

Introduction: Cancer is a disorder involving uncontrolled growing cells that have the ability to invade and spread to other areas of the body. Drugs for chemotherapy cause damage to non-cancer cells and leads to low count of blood cells. There are controversial findings on the difference of the count on blood cell types. Studies are limited on the count of blood cell type before and after chemotherapy. Therefore, this study aimed to address this gap.
Method: Institutional based longitudinal study design was done on 354 patients to compare blood cell types profile in pre and post-operative from September1, 2022 to October 1, 2022. Data extraction format was used to collection data source. To assure data quality, first data were entered and cleaned to epidata version 4.6 then exported to SPSS version 23 for analysis. Paired t-test was used to analysis data.
Result: data was collected from 354 patients. The mean age of the respondent was 41.26 (±16.67). In the first diagnosis, nearly all of them reached stage III 167 (47%) and stage IV 159 (45%). All profiles of blood cell type showed decrement in post chemotherapy compared to pre-chemotherapy. The mean decrement of platelet is 23. 51×103cells/mm3 (p=0.001), red blood cell is 0.63×106cells/mm3 (p=0.08) and white blood cell is 2.49 ×106 cells/mm3 (p=0.012) respectively.
Conclusion: After chemotherapy, all profiles of blood cells count decreased. This means chemotherapy had significant effect on the number of all type of blood cells.
Numerical Investigation of Modifying the Design Parameters in Vortex Tube Separators for Enhanced Cooling Performance
Authors: Jawad Layth H. 
Published: September 2024

Abstract

In This paper presents a thorough numerical analysis of how different design parameters and operating conditions affect the thermal performance of vortex tube separators. We investigated two models: one with a complete cone valve and the other with a truncated cone valve. The purpose of the research was to simulate and evaluate the efficiency of both designs using the RSM turbulence model in Ansys Fluent. The simulations validated the model's reliability by showing strong agreement with experimental data. The findings showed that improved thermal performance is an obvious result of higher intake pressure. More specifically, compared to the truncated cone model, the complete cone valve model performed better, exhibiting a 122% increase in heat pump efficiency and a 57% increase in cooling capacity. Furthermore, the research determined the ideal cold fraction values to optimize the vortex tube's performance. These results indicate that vortex tube separators may be made far more successful in real-world applications by implementing certain design changes, including adding a complete cone valve. The knowledge gathered from this study provides important direction for enhancing vortex tube technology in different thermal management systems.
Energy-efficient field-free unconventional spin-orbit torque magnetization switching dynamics in van der Waals heterostructures
Authors: Dash Saroj , Pandey Lalit , Zhao Bing , Bangar Himanshu , Sjöström Lars , Ngaloy Roselle , Rout Prasanna , Ali Aya , Abdel-Hafiez Mahmoud , Zhang Gaojie , Wu Hao , Chang Haixin 
Published: September 2024

Abstract

The van der Waals (vdW) heterostructure of emerging two-dimensional (2D) quantum materials, with control over their quantum geometries, crystal symmetries, spin-orbit coupling, and magnetic anisotropies, provides a new platform for generating unconventional nonlinear Hall effects, spin polarization and efficiently controlling the magnetization dynamics for non-volatile spin-based computing. However, so far, the generation of a large out-of-plane spin polarization is limited to achieve energy-efficient field-free magnetization switching and spin dynamics measurements in all-2D vdW heterostructure are so far missing, where the interplay between spins and magnetization dynamics should enable the design of ultrafast spintronic devices. Here, we demonstrate magnetization dynamics and energy-efficient field-free spin-orbit torque (SOT) switching of out-of-plane magnet Fe3GaTe2 due to unconventional Berry curvature-induced out-of-plane spin polarization from a topological Weyl semimetal TaIrTe4 in a vdW heterostructure at room temperature. We observed a large non-linear 2nd harmonic Hall signal at room temperature and evaluated the SOT-induced magnetization dynamics with a large damping-like torque of 4.83±0.59 mT per MAcm(-2). Deterministic field-free SOT magnetization switching in vdW heterostructure of TaIrTe4/Fe3GaTe2 is observed at room temperature with a low current and power density of 1.81 ×1010 A/m2 and 0.175×1015 W/m3 , respectively, which is an order of magnitude better than that of conventional systems. From the magnetization switching experiments, the SOT efficiency is found to be 3.95 with a very large spin Hall conductivity of 7.39×106 ħ/2e (Ω m)(–1) . These findings on all-vdW heterostructures offer a promising route to energy-efficient and external field-free ultrafast spintronic technologies.
Access to optimal treatment of acute myeloid leukemia patients is affected by sociodemographic factors: a French population-based study.
Authors: ATSOU Kueshivi Midodji , RACHET Bernard , MARINGE Camille , CORNET Edouard , CHRETIEN Marie-Lorraine , ROSSI Cédric , REMONTET Laurent , GIORGI Roch , WASSE Stéphane Kroudia , GAUTHIER Sophie , GIRARD Stéphanie , BÖCKLE Johann , RACHOU Helene , BOUZID Laila , PONCET Jean-Marc , ORAZIO Sébastien , MONNEREAU Alain , TROUSSARD Xavier , MAYNADIE Marc 
Published: September 2024

Abstract

Background
During their care pathway, AML patients not admitted to Specialized Hematology Units (SHU) have less access to curative treatment. We aim to determine whether access to optimal curative treatment is affected by sociodemographic factors.
Methods
We included 1,033 incidents AML-cases diagnosed between 2012–2016 from three French “départements”. We considered patients managed in reference hospitals SHU within 5 days(n = 297) received “gold-standard” treatment. Treatment was "curative-treatment” if intensive chemotherapy and “non-curative” otherwise. Firstly, we trained a Gradian Boosting Machine (GBM) algorithm on 80%(n = 238) of "gold-standard" cases to learn how they were treated and validated the model on the remaining 20%(n = 59). Next, GBM predictions were contrasted with actual treatment. Using multivariable logistic regression, we examined how non-optimal treatment (discrepancy between predicted curative and observed non-curative treatment) was associated with sociodemographic factors. Patients with predicted non-curative treatment were excluded as uninformative on access to curative treatment (n = 471).
Results
The rate of “curative treatment” was 84.8% (252/297) for gold-standard patients vs. 33.5% (247/736) for others. The three most influential predictive factors in gold-standard patients were age (68.3%-influence), t-AML/MDS (15.8%), and the AML-others subtypes (5.4%). A total of n = 102(9.9%) patients were in non-optimal treatments. Living in Basse-Normandie (0.65-times;95%CI [0.5,0.8]) and over 30minutes from a reference hospital were strongly associated with a non-optimal treatment.
Conclusion
There are geographical disparities in access to optimal treatment, potentially linked to medical desert situations or medical system organization which must be addressed.
Hypermethylation of Hif3a and Ifltd1 Is Associated with Atrial Remodeling in Pressure- overload Murine Model
Authors: Abe Keiko , Sasano Tetsuo , Soejima Yurie , Fukayama Haruhisa , Maeda Shigeru , Furukawa Tetsushi 
Published: September 2024

Abstract

Atrial remodeling is one of major pathophysiological mechanisms of atrial fibrillation (AF). Atrial remodeling progresses based on aging, background diseases including hypertension and heart failure, and AF itself. However, its mechanism and reversibility have not been completely elucidated. In this study, we focused on the involvement of DNA methylation in atrial remodeling. Mice underwent transverse aortic constriction (TAC) procedure to generate pressure overload model. After 14 days, TAC-operated mice showed a significant increase in atrium/body weight ratio and deposition of collagen fiber in atria. Comprehensive analysis of RNA-Sequencing (RNA-Seq) and Methyl-CpG-Binding Domain Sequencing (MBD-Seq) in left atrial tissue identified Hif3a and Ifltd1 showing increased DNA methylation in their promoter regions and decreased RNA expression. We also performed transient pressure overload model by removing aortic constriction at 3 or 7 days after initial TAC procedure (R3 or R7 groups). The reduction of RNA expression was achieved at R3 for Hif3a, and in R7 for Ifltd1. The heterozygous Dnmt1 gene targeting mouse (Dnmt1 mut) showed disappearance of the reduction in RNA expression and increase in atrium/body weight ratio. DNA methylation was thought to contribute to at least part of the atrial remodeling in the pressure overload mouse model.