bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of regional climate and teleconnection on hydrological change in the Bosten Lake Basin, arid region of northwestern China
Authors: Wang Huaijun , Pan Yingping , Chen Yaning 
Published: October 2017

AbstractThis investigation examined effects of climate change, measured as annual, seasonal, and monthly air temperature and precipitation from 1958 to 2010, on water resources (i.e., runoff) in the Bosten Lake Basin. Additionally, teleconnections of hydrological changes to large-scale circulation indices including El Nino Southern Oscillation (ENSO), Arctic Oscillation (AO), North Atlantic Oscillation (NAO), Tibetan High (XZH), westerly circulation index (WI), and northern hemisphere polar vortex area index (VPA) were analyzed in our study. The results showed the following. (1) Annual and seasonal air temperature increased significantly in the Bosten Lake Basin. Precipitation exhibited an increasing trend, while the significance was less than that of temperature. Abrupt changes were observed in 1996 in mountain temperature and in 1985 in plain temperature. (2) Runoff varied in three stages, decreasing before 1986, increasing from 1987 to 2003, and decreasing after 2003. (3) Precipitation and air temperature have significant impacts on runoff. The hydrological processes in the Bosten Lake Basin were (statistically) significantly affected by the northern hemisphere polar vortex area index (VPA) and the Tibetan High (XZH). The results of this study are good indicators of local climate change, which can enhance human mitigation of climate warming in the Bosten Lake Basin.
A Validated Stability-Indicating HPTLC Method for the Estimation of Capecitabine in its Tablet Dosage Form
Authors: Thorat Sonali , Chikhale Rupesh , Rode Vanita , Tajne Madhukar 
Published: October 2017

Background:Capecitabine is an orally available prodrug of 5-flurouracil used in the treatment of breast cancer, metastatic colorectal cancer and stage III colorectal cancer. Various studies have reported the HPLC, HPLC-MS, MS/MS methods for estimation of capecitabine. However, till date HPTLC method for estimation of capecitabine and its validation is not reported in tablet dosage form.Introduction:Presented study deals with the development and validation of stability indicating high performance thin layer chromatography method for the determination of Capecitabine in tablet dosage form.Methods:The method was developed using precoated HPTLC plates with silica gel 60 F254 as stationary phase and toluene-methanol the ratio of 7.5:2.5 v/v as the mobile phase. Capecitabine (RF 0.48 ± 0.03) and its degradation products were well resolved. The wavelength selected for study was 240 nm. The method was linear in the concentration range 50–550 ng/band with a correlation coefficient of 0.994. The repeatability for six samples was 1.25% RSD. The intraday and interday precisions were 1.46-1.71%RSD and 1.31-1.67% RSD, respectively. The accuracy (recovery) was found to be in the range of 99.10-101.23% with LOD and LOQ were found to be 0.650 and 1.765 mg/band. The mean content of drug in tablet dosage form was found to be 101.51% with a % RSD of 1.20. The drug was subjected to stress conditions such as hydrolysis, oxidation, photolysis, and heat.Results:Degradation products produced as a result of the stress conditions did not interfere with the detection of Capecitabine; therefore, the proposed technique can be considered stability-indicating. Capecitabine did not degrade under thermal and photolytic conditions but showed degradation under acidic and alkaline conditions with 15 and 11% decompositions respectively.Conclusion:The developed method was found to be facile, simple, specific, precise, and stabilityindicating. It can be employed for the routine analysis of capecitabine in tablet dosage form.
Hospital cost impact of orbital atherectomy with angioplasty for critical limb ischemia treatment: a modeling approach
Authors: Shammas Nicolas W , Boyes Christopher W , Palli Swetha R , Rizzo John A , Martinsen Brad J , Kotlarz Harry , Mustapha JA 
Published: October 2017

Aim:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated.Materials & methods:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incremental cost of OAS + BA versus BA-only included differential utilization during the procedure and adverse-event costs at 3, 6 and 12-months.Results:For every 100 procedures, incremental annual costs to the hospital were US$350,930 lower with OAS + BA compared with BA-only. Despite higher upfront costs, savings were realized due to reduced need for revascularization, amputation and end-of-life care over 6–12-month postoperative period.Conclusion:Atherectomy with OAS prior to BA was associated with cost savings to the hospital.
Correlation between periodontal soft tissue and hard tissue surrounding incisors in skeletal Class III patients
Authors: Park Jeong-Ho , Hong Ji-Yeon , Ahn Hyo-Won , Kim Su-Jung 
Published: October 2017

ABSTRACTObjectives:To investigate the association between the periodontal soft tissue, alveolar bone and dental parameters surrounding the incisors at baseline in patients with skeletal Class III malocclusion.Materials and Methods:The study sample comprised 154 teeth from 28 patients with skeletal Class III malocclusion (19 men and 9 women, 21.15 ± 4.02 years). Periodontal soft tissue examination and hard tissue measurements with cone-beam computed tomography (CBCT) were performed. Factor analysis was used to reduce the CBCT variables, and correlation analysis between the hard tissue factors and soft tissue parameters was performed. Differences in hard tissue parameters between thick and thin gingival types were evaluated.Results:CBCT measurements were reduced to three hard tissue factors: lingual plate, coronal-buccal plate, and apical-buccal plate. Keratinized gingiva width and thickness were positively correlated with the coronal-buccal plate factor and negatively correlated with the apical-buccal plate factor. In the thin gingival biotype, mandibular incisors were more proclined, and the apical part of the buccal alveolar plate and the coronal part of lingual alveolar plate were thicker than in the thick gingival biotype.Conclusions:In the anterior teeth in cases of skeletal Class III malocclusion, hard tissue structures on the buccal side can be grouped based on coronal and apical factors that are significantly correlated with keratinized gingival width and thickness. Thick and thin gingival biotypes exhibited differences in tooth inclination and alveolar plate thickness with regard to the mandibular incisors.
Influences on Diabetes Self-Management Education Participation in a Low-Income, Spanish-Speaking, Latino Population
Authors: Testerman Jill , Chase Dian 
Published: October 2017

Objective.
To investigate influences on participation in diabetes self-management education (DSME) classes in a low-income, Spanish-speaking, Latino population.

Methods.
Fifteen patients from an Oregon clinic participated in semi-structured interviews designed to understand influences on their participation in DSME classes, and the authors conducted a thematic analysis.

Results.
Four themes characterized the data: 1) limited resources, 2) culture, 3) relationship with diabetes, and 4) relationship with clinic. Barriers to class attendance included lack of time, childcare, and transportation; male participants’ shame of illness and lack of interest in health; and difficulty contacting participants by telephone. Motivators of class attendance included interest in being healthy for the sake of family; interest in nutrition; knowledge of the effects of diabetes on self, friends, and family; and positive experiences with group support and self-efficacy in class.

Practice implications and conclusion.
Participation in DSME classes in this low-income, Spanish-speaking, Latino population was influenced by many factors. Understanding these factors is an important step toward creating classes that are successful in increasing attendance rates for this and similar populations. Creative, targeted approaches to designing DSME classes for low-income, Spanish-speaking, Latino patients and similar populations are needed. These may include classes that remove the barriers of shame and lack of interest for male participants; focus on family involvement, celebration of culturally appropriate foods, group support, and self-efficacy; are accessible to resource-limited participants; and use alternative methods to recruit hard-to-reach participants.
Estado, individuo e identidad
Authors: Arrúa Néstor Nicolás 
Published: October 2017

El derrumbe del campo socialista y la reestructuración capitalista del trabajo consolidó la emergencia del neoliberalismo a escala mundial apoyado en la caída de los grandes relatos de la modernidad, que concebían sujetos de la historia hacia una meta de progreso cultural y económico. El neoliberalismo produjo reformas laborales y productivas que desencadenaron un redimensionamiento del mapa demográfico y económico mundial, con consecuencias de desplazamientos masivos de poblaciones ante la guerra y la penuria económica. Esto pone en jaque a los Estados nacionales que deben atravesar procesos de desterritorialización/territorialización de diversos sectores de su población, afectando las concepciones de ciudadanía y democracia dominantes en dichas sociedades.
El individuo deseado por las políticas e ideologías neoliberales como autosufi ciente y dueño de sí mismo, repercute en la conformación de políticas dirigidas a atender la cuestión social, bajo una perspectiva ligada al empoderamiento y el emprendedorismo. Estas se encuentran atravesadas por procesos combinados de explotación del trabajo en las sociedades periféricas, que transforman las identidades colectivas y formas de protesta en la coyuntura actual. De esta manera, ante un individuo autoabastecido, conminado al consumo y el placer, la construcción de lo colectivo está a la orden del día.
Palabras claves: Neoliberalismo - individuo - identidad- Estado - Ideología
The Study of a Possible Correlation between Serum Levels of Interleukin 17 and Clinical Severity in Patients with Allergic Rhinitis
Authors: Aly Mai Aly Gharib , El Tabbakh Mohamed Tawfik , Heissam Waheed Fawzy , Abbadi Said Hamed 
Published: October 2017

Introduction Allergic rhinitis (AR) is one of the most common allergic diseases, which affects ~20% of the world's population. T-helper (Th) type 2 cells produce interleukin (IL) 4 and IL-13, and mediate allergic responses, and these cytokines have been extensively studied as key players in the atopic airway diseases. However, the involvement of Th17 cells and IL-17 in AR has not been clearly examined. Aim To reevaluate AR clinical severity with serum IL-17, whether IL-17 affects the disease alone or in contribution with the atopic predisposition. Patients and Methods During an 18-month period, 39 individuals were divided into three groups: A, (13 control), B (13 with mild-to-moderate AR), and C (13 with severe AR). Both group B and group C patients (26) were subjected to clinical examination and allergy skin testing, and to measurement of both total serum immunoglobulin E (IgE) and IL-17 levels. Eleven patients with AR then were exposed to 6 months of cluster immunotherapy, whereas the rest of the patients were not exposed. Results Revealed a significant elevation of serum IL-17 levels with an associated increase in serum IgE in the patients with AR compared with controls and revealed that the serum levels of both total serum IgE and IL-17 decreased significantly after cluster immunotherapy. Conclusion These preliminary results added new data about the use of injective immunotherapy as well as reported on the use of sublingual immunotherapy.
Long-term follow-up of a Patient with Malignant Transformation of Inverted Papilloma into Sinonasal Undifferentiated Carcinoma
Authors: Orgain Carolyn A. , Shibuya Terry Y. , Thompson Lester D. , Keschner David B. , Garg Rohit , Lee Jivianne T. 
Published: October 2017

Introduction Inverted papillomas (IP) are benign sinonasal neoplasms, which account for 0.5–4% of all nasal tumors. IPs have been known to transform into squamous cell carcinoma in 5–15% of cases. Rarely, transformations to other malignancies have been reported. Here we report a unique case of malignant transformation of an IP into sinonasal undifferentiated carcinoma (SNUC). Methods A case report with a literature review; institutional review board exempted. The clinical presentation, radiographic features, surgical intervention, histopathologic analysis, treatment, and outcome of the case were examined. Results A 62-year-old man presented with a 3-month history of nasal airway obstruction, rhinorrhea, and postnasal drip refractory to medical therapy. He had a long history of exposure to fumes, chemicals, dusts, and solvents as a professional painter as well as a 45 pack-year history of smoking and alcohol abuse. The patient was ultimately found to have a left ethmoidal IP with a focus of malignant transformation into SNUC. Endoscopic resection was performed, followed by concurrent chemoradiation and adjuvant chemotherapy. After surgery, he had no evidence of recurrent disease after 9 years of follow-up. Conclusions IP is known to transform into squamous cell carcinoma. Here we report a rare case of malignant transformation into SNUC, a much more uncommon and aggressive lesion. Although traditionally associated with a poorer prognosis, the positive outcome for SNUC observed in this patient may potentially be attributed to early detection and timely therapeutic intervention.
Multiple Doses of Icatibant used during Pregnancy
Authors: Kaminsky Lauren W. , Kelbel Theodore , Ansary Fay , Craig Timothy 
Published: October 2017

Background Hereditary angioedema (HAE) is a life-long disease that often manifests by puberty. Treatment of attacks is essential to improve quality of life and to decrease morbidity and mortality. During pregnancy, treatment is limited because multiple treatment options, including icatibant, are not approved for use during pregnancy. Objective We report the outcomes of three pregnancies during which icatibant was used by a patient with HAE with normal C1-inhibitor for treatment of attacks. We also reviewed the literature for reports of icatibant use during pregnancy for outcomes and adverse events. Methods We report on a patient who treated herself with icatibant during three separate pregnancies. Postpartum follow-up verified the health of the mother and children. We also performed a complete literature search of medical literature data bases on icatibant use during pregnancy. Results The patient in our report administered multiple doses of icatibant during three pregnancies. The child born from the first pregnancy and the child from the third pregnancy were born at term and without congenital anomalies. The child from the second pregnancy was 1-month preterm. All three children were developmentally normal. The literature search identified two case reports and one abstract of limited icatibant use without adverse events during pregnancy in patients with HAE. These pregnancies resulted in the births of healthy infants. Conclusion From a search of the literature, three cases of icatibant use during pregnancy resulted in healthy infants. In addition, we report that from icatibant use in three separate pregnancies, one infant was born prematurely, but there were no birth defects. From follow-up, the children continued meeting developmental milestones. This report adds to the acquisition of knowledge for drug adverse events during postmarketing surveillance for icatibant use during pregnancy.
Prenatal Maternal Depression Related to Allergic Rhinoconjunctivitis in the first 5 Years of Life in Children of the EDEN Mother-Child Cohort Study
Authors: Zhou Cailiang , Ibanez Gladys , Miramont Vincent , Steinecker Magali , Baiz Nour , Banerjee Soutrik , Just Jocelyne , Annesi-Maesano Isabella , Chastang Julie ,   EDEN Mother-Child Cohort Study Group, Charles Marie Aline , de Agostini Maria , Forhan Anne , Heude Barbara , Ducimetère Pierre , Kaminski Monique , Saurel-Cubizolles Marie-Josèphe , Dargent-Molina Partricia , Fritel Xavier , Larroque Beatrice , Lelong Nathalie , Marchand Laetitia , Nabet Cathy , Annesi-Maesano Isabella , Slama Remy , Goua Valŕie , Nlagnin Guillaume , Hankard Régis , Thiebaugeorges Olivier , Schweitzer Michel , Foliguet Bernard , Job-Spira Nadine 
Published: October 2017

Backgroud Evidence about the relationship between prenatal maternal depression and the development of childhood asthma and allergies in early life is scarce. We aimed to examine this relationship by using data set of EDEN mother-child cohort study. A total of 1139 children were followed-up until the age of 5 years. Methods Prenatal maternal depression was self-reported by using the Centre for Epidemiological Studies-Depression scale (CES-D) questionnaire and was classified into binary variable (maternal depression [CES-D score of≥16] and no maternal depression [CES-D score of <16]). Asthma and allergies in the first 5 years were assessed by using the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC). Adjusted odds ratio (aOR) was estimated for the relationship between prenatal maternal depression and early life asthma and allergies by marginal models through the method of generalized estimating equation (GEE) when adjusting for the confounders. Results In our study population, 13.67 % of the mothers had clinical significant depression (the total scores for CES-D ≥16) during pregnancy. For children ages 5 years, the prevalence of wheezing, physician-diagnosed asthma, physician-diagnosed eczema and allergic rhinoconjunctivitis were 46.78, 20.99, 29.17, and 22.54%, respectively. Prenatal maternal depression was associated with ever allergic rhinoconjunctivitis (aOR 1.87 [95% confidence interval {CI}, 1.33–2.62]). No significant relationships were found between prenatal maternal depression and wheezing, physician-diagnosed asthma and physician-diagnosed eczema (aOR 1.12 [95% CI, 0.91–1.39], aOR 1.23 [95% CI, 0.81–1.85] and aOR 1.17 [95% CI, 0.86–1.61], respecitvely). Conclusion Prenatal maternal depression was related to ever allergic rhinoconjunctivitis in the first 5 years of life in children of EDEN mother-child cohort study.
An Ergonomic Assessment of Operating Table and Surgical Stool Heights for Seated Otolaryngology Procedures
Authors: Azimuddin Anam F. , Weitzel Erik K. , McMains Kevin C. , Chen Philip G. 
Published: October 2017

Background Musculoskeletal injuries, such as neck and back pain, during a surgeon's career are common. However, studies on ergonomics are limited with regard to seated otolaryngologic procedures. Key elements of an ergonomic operating environment include the height of operating tables and surgical chairs. Surgeons benefit from proper support and positioning to prevent musculoskeletal injuries and reduce occupational risk. Objective The purpose of this study was to evaluate operating table and surgical seat heights, and determine whether adjustments can be made for various surgeon physiques. Methods Operating tables and surgical seat dimensions were measured at local hospitals, and the information was complemented by an online search of other models. Results Five unique operating tables and five unique surgical stools were identified, both in the local hospital and in a search on the Internet. Of available tables, the greatest range was 63.5–124.5 cm, which reaches above the maximum suggested working height of 76.2 cm. The surgical stool with the widest range was adjustable from heights of 50.8–72.4 cm. This combination of operative table and surgical stool provided the greatest range of heights. Conclusion Of the available tables and stools measured, the combination of surgical table with a range of 63.5–125.7 cm and surgical stool with a range of 50.8–72.4 cm provided the greatest versatility for diverse physician heights. In ergonomic terms, this combination may reduce physical fatigue and create a potentially safer working environment for seated surgeons.
A Multicenter, Prospective, Noninterventional Study in a Norwegian Cohort of Patients with Moderate-to-Severe Allergic Rhinitis Treated with MP-AzeFlu
Authors: Dollner Ralph , Larsen Petter Lorentz , Dheyauldeen Sinan , Steinsvåg Sverre 
Published: October 2017

Background Allergic Rhinitis and its Impact on Asthma guidelines recently recommended a treatment strategy for allergic rhinitis (AR) based on disease control rather than symptom severity by using a visual analog scale (VAS) to categorize control Objectives To evaluate the effectiveness of MP-AzeFlu (Dymista®) by using this VAS in routine clinical practice in Norway. MP-AzeFlu comprises a novel formulation that contains azelastine hydrochloride, fluticasone propionate and excipients delivered in a single spray. Methods This multicenter, prospective, noninterventional study enrolled patients (n = 160) with moderate-to-severe AR and acute symptoms who were eligible to receive treatment with MP-AzeFlu according to its summary of product characteristics. Patients assessed symptom severity by using a VAS from 0 (not at all bothersome) to 100 mm (very bothersome) in the morning before MP-AzeFlu use on days 0, 1, 3, 7, and after ~14 days. On day 3, the patients assessed their level of disease control as well controlled, partly controlled, or uncontrolled. The proportion of Norwegian patients who achieved defined VAS score cutoffs for “well-controlled” and “partly controlled” AR were also calculated. Results MP-AzeFlu reduced the mean ± standard deviation VAS score from 68.1 ± 16.4 mm at baseline to 37.4 ± 25.9 mm on the last day, a reduction of 30.8 ± 27.2 mm. The results were consistent, irrespective of disease severity, phenotype (i.e., seasonal AR [SAR], perennial AR [PAR], SAR plus PAR, unknown) or age (i.e., 12–17, 18–65, and >65 years). Of the patients (with recorded data), 88.1% considered their symptoms to be partly or well controlled at day 3; and 19.5, 32.0, 50.0, and 61.0% of the patients achieved a ≤38 mm well-controlled VAS score cutoff on days 1, 3, 7, and the last day, respectively. Conclusions MP-AzeFlu provided rapid sustained symptom control in a routine clinical practice in Norway, which provided support for its effectiveness for the treatment of AR in real life.
Factors Determining the Effective Role of Microfinance
Authors: Imran Shahina , Arshad Rana M Imran 
Published: October 2017

The focus of this study is on the effectiveness of economic, social and institutional factors in manipulating the role of microfinance. It is a primary data research conducted in the Bahawalpur division, Pakistan. The sample consists of 773 respondents, belonging to different microfinance providers of Pakistan that are NRSP, AKHU, FMFB, KASHF, KB, NRSP-B, TMFB. Data has been collected through face to face structured interviewing using a questionnaire. It has been found that economic wellbeing and economic empowerment of borrowers after availing microfinance is positively affected by consumer protection, education of borrowers, experience, business training, number of employed persons, length of membership, relation to household head, area and family reaction to business activity but negatively by diversion of loan, interest rate, age of the borrowers and number of dependents.