bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOCCCDTA-based Current Mode Tunable Universal Biquad Filter for Bluetooth Applications
Authors: Sharma Jyoti , Chakraborty Shantanu 
Published: October 2016

<p>In the last decade, there has been much effort to reduce the supply voltage of electronic circuits due to the demand for portable and battery-powered equipment. Since a low-voltage operating circuit becomes necessary, the current-mode technique is ideally suited for this purpose more than the voltage-mode one. In this paper, performance of multi output current controlled current differencing transconductance amplifier (MOCCCDTA) is evaluated using 180nm, 90nm and 45nm CMOS technology. It is found that the 45nm CMOS-based<br />MOCCCDTA provides highest frequency i.e. 33GHz. Further a Universal biquad filter has been designed using a single MOCCCDTA as an active element and two capacitors. Filter offers high frequency in GHz. Tunability of all the filter outputs with respect to a bias current has been analyzed. The tunability of the filter circuit for Bluetooth applications is also shown in this work. The performances of MOCCCDTA circuit and Universal biquad filter are illustrated by HSPICE. The simulation results are found to be in agreement with the theoretical predictions.</p>
Hybrid Approach for Prediction of Cardiovascular Disease Using Class Association Rules and MLP
Authors: Konda Srinivas , Balmuri Kavitha Rani , Basireddy Ramasubba Reddy , Mogili Ravindar 
Published: October 2016

<strong><span>: </span></strong><span>In data mining classification techniques are used to predict group membership for data instances. These techniques are capable of processing a wider variety of data and the output can be easily interpreted. The aim of any classification algorithm is the design and conception of a standard model with reference to the given input. The model thus generated may be deployed to classify new examples or enable a better comprehension of available data. Medical data classification is the process of transforming descriptions of medical diagnoses and procedures used to find hidden information. Two experiments are performed to identify the prediction accuracy of Cardiovascular Disease (CVD).A hybrid approach for classification is proposed in this paper by combining the results of the associate classifier and artificial neural networks (MLP). The first experiment is performed using associative classifier to identify the key attributes which contribute more towards the decision by taking the 13 independent attributes as input. Subsequently classification using Multi Layer Perceptrons (MLP) also performed to generate the accuracy of prediction using all attributes. In the second experiment, identified key attributes using associative classifier are used as inputs for the feed forward neural networks for predicting the presence or absence of CVD.</span>
Non-Reentrant Fascicular Tachycardia
Authors: Talib Ahmed Karim , Nogami Akihiko , Morishima Itsuro , Oginosawa Yasushi , Kurosaki Kenji , Kowase Shinya , Komatsu Yuki , Kuroki Kenji , Igarashi Miyako , Sekiguchi Yukio , Aonuma Kazutaka 
Published: October 2016

Background—
The most common form of idiopathic Purkinje-related ventricular tachycardia (VT) is the reentrant type. We describe the clinical and electrophysiological characteristics of focal non-reentrant fascicular tachycardia.

Methods and Results—
Among 530 idiopathic VT patients who were referred for ablation, we identified 15 (2.8%) with non-reentrant fascicular tachycardia (11 men, 45±21 years). Sinus rhythm ECG showed normal conduction intervals with a His–ventricular interval of 41±4 ms. All patients had monomorphic VT (cycle length: 337±88 ms) with a relatively narrow QRS (123±12 ms), and they did not respond to verapamil during the initial presentation. VT exhibited right bundle-branch block/superior axis configuration in 11 patients (73%) and inferior axis in 3 (20%). In 1 patient (7%), VT exhibited left bundle-branch block/superior axis configuration. During ablation, spontaneous VT occurred in 3 patients (20%) and nonentraintable VT or identical premature ventricular complex was induced in 9 (60%). A high-frequency presystolic Purkinje potential was recorded during VT/premature ventricular complex, preceding the QRS by 25±16 ms. VT recurrence was observed in 4 patients (27%), and among them, 3 underwent pacemap-guided ablation during the first session. A second ablation with activation mapping guidance eliminated the VT during the 88±8-month follow-up.

Conclusions—
Among idiopathic VT cases referred for ablation, 2.8% were focal non-reentrant fascicular tachycardia, which had distinct clinical characteristics and usually originated from the left posterior fascicle, and less commonly from the left anterior fascicle and right ventricular Purkinje network. Catheter ablation is effective, whereas pacemap-guided approach is less efficacious.
Association Between Left Atrial Dilatation and Invasive Hemodynamics at Rest and During Exercise in Asymptomatic Aortic Stenosis
Authors: Christensen Nicolaj Lyhne , Dahl Jordi Sanchez , Carter-Storch Rasmus , Bakkestrøm Rine , Jensen Kurt , Steffensen Flemming Hald , Søndergaard Eva Vad , Videbæk Lars , Møller Jacob Eifer 
Published: October 2016

Background—
Transition from an asymptomatic to symptomatic state in severe aortic stenosis is often difficult to assess. Identification of a morphological sign of increased hemodynamic load may be important in asymptomatic aortic stenosis to identify patients at risk.

Methods and Results—

Thirty-nine patients with asymptomatic severe aortic stenosis (aortic valve area <1 cm
2
, peak jet velocity >3.5 m/s) underwent exercise testing with simultaneous invasive hemodynamic monitoring and Doppler echocardiography. Cardiac index, pulmonary artery pressure, and pulmonary capillary wedge pressure (PCWP) were recorded. Patients were followed up for the composite end point of death, unplanned hospitalization, or aortic valve replacement. Patients were stratified into 2 groups according to left atrial (LA) volume index ≥35 mL/m
2
. In 25 patients (64%) LA volume index was ≥35 mL/m
2
. Aortic valve area was similar between groups (0.81±0.15 versus 0.84±0.18 cm
2
;
P
=0.58). PCWP was higher at rest and during exercise in patients with LA volume index ≥35 mL/m
2
(
P
<0.01), despite similar cardiac index. At rest, PCWP was <12 mm Hg in 11 patients (44%) with LA dilatation, whereas PCWP was <25 mm Hg in 1 patient (4%) with exercise. LA volume index and E/e′ predicted exercise PCWP>30 mm Hg with areas under the receiver operating curve of 0.75 and 0.84, respectively. During follow-up, 14 cardiac events were recorded. LA volume was associated with a hazard ratio of 1.90 (95% confidence interval, 0.92–4.15).

Conclusions—
LA size reflects hemodynamic burden in patients with asymptomatic severe aortic stenosis. Quantitative measurements of LA and diastolic function are associated with left ventricular filling pressures with exercise and could be used to identify asymptomatic patients with increased hemodynamic burden.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02395107.
Effects of Concurrent Depressive Symptoms and Perceived Stress on Cardiovascular Risk in Low‐ and High‐Income Participants: Findings From the Reasons for Geographical and Racial Differences in Stroke (REGARDS) Study
Authors: Sumner Jennifer A. , Khodneva Yulia , Muntner Paul , Redmond Nicole , Lewis Marquita W. , Davidson Karina W. , Edmondson Donald , Richman Joshua , Safford Monika M. 
Published: October 2016

Background

Psychosocial risk for cardiovascular disease (
CVD
) may be especially deleterious in persons with low socioeconomic status. Most work has focused on psychosocial factors individually, but emerging research suggests that the confluence of psychosocial risk may be particularly harmful. Using data from the Reasons for Geographical and Racial Differences in Stroke (
REGARDS
) study, we examined associations among depressive symptoms and stress, alone and in combination, and incident
CVD
and all‐cause mortality as a function of
socioeconomic status
.

Methods and Results

At baseline, 22 658 participants without a history of
CVD
(58.8% female, 41.7% black, mean age 63.9±9.3 years) reported on depressive symptoms, stress, annual household income, and education. Participants were classified into 1 of 3 psychosocial risk groups at baseline: (1) neither depressive symptoms nor stress, (2) either depressive symptoms or stress, or (3) both depressive symptoms and stress. Cox proportional hazards models were used to predict physician‐adjudicated incident total
CVD
events (nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death) and all‐cause mortality over a median of 7.0 years (interquartile range 5.4–8.3 years) of follow‐up. In fully adjusted models, participants with both depressive symptoms and stress had the greatest elevation in risk of developing total
CVD
(hazard ratio 1.48, 95%
CI
1.21–1.81) and all‐cause mortality (hazard ratio 1.33, 95%
CI
1.13–1.56) but only for those with low income (<$35 000) and not high (≥$35 000) income. This pattern of results was not observed in models stratified by education.

Conclusions

Findings suggest that screening for a combination of elevated depressive symptoms and stress in low‐income persons may help identify those at increased risk of incident
CVD
and mortality.
Cepolacanthus kimi, a new genus and species of copepod (Cyclopoida: Taeniacanthidae) parasitic on Bandfish Acanthocepola abbreviata (Valenciennes, 1835) (Actinopterygii: Cepolidae) caught off the Iraqi coast
Authors: MARAN BALU ALAGAR VENMATHI , MOON SEONG YONG , ADDAY THAMIR KATEA , TANG DANNY 
Published: October 2016

A new genus and species, Cepolacanthus kimi, of the family Taeniacanthidae is established based on adult female specimens collected from the gills of Bandfish Acanthocepola abbreviata (Valenciennes, 1835) (Actinopterygii: Perciformes: Cepolidae) caught off the coast of Iraq. The new genus is characterised by the following combination of features: 1) the urosome is composed of five somites, with the last urosomite probably being a compound somite formed from the failure of the third and fourth abdominal somites to separate; 2) the seta on the maxillary basis is displaced proximally from the free spinulated element; 3) the terminal claw (endopod) of the maxilliped is long and attenuate; 4) the endopod of legs 2–4 is 2-segmented; and 5) the terminal exopodal segment of leg 4 bears a prominent distolateral protuberance. Cepolacanthus kimi gen. et sp. nov. is the first copepod reported from A. abbreviata and the second taeniacanthid species recorded from the Iraqi coast. A new replacement name, Suncheonacanthus nom. nov., is proposed for the preoccupied generic name, Triacanthus Kim & Moon, 2013.
Precursors to suicidality and violence on antidepressants: systematic review of trials in adult healthy volunteers
Authors: Bielefeldt Andreas Ø , Danborg Pia B , Gøtzsche Peter C 
Published: October 2016

Objective To quantify the risk of suicidality and violence when selective serotonin and serotonin-norepinephrine reuptake inhibitors are given to adult healthy volunteers with no signs of a mental disorder. Design Systematic review and meta-analysis. Main outcome measure Harms related to suicidality, hostility, activation events, psychotic events and mood disturbances. Setting Published trials identified by searching PubMed and Embase and clinical study reports obtained from the European and UK drug regulators. Participants Double-blind, placebo-controlled trials in adult healthy volunteers that reported on suicidality or violence or precursor events to suicidality or violence. Results A total of 5787 publications were screened and 130 trials fulfilled our inclusion criteria. The trials were generally uninformative; 97 trials did not report the randomisation method, 75 trials did not report any discontinuations and 63 trials did not report any adverse events or lack thereof. Eleven of the 130 published trials and two of 29 clinical study reports we received from the regulatory agencies presented data for our meta-analysis. Treatment of adult healthy volunteers with antidepressants doubled their risk of harms related to suicidality and violence, odds ratio 1.85 (95% confidence interval 1.11 to 3.08, p = 0.02, I2 = 18%). The number needed to treat to harm one healthy person was 16 (95% confidence interval 8 to 100; Mantel-Haenszel risk difference 0.06). There can be little doubt that we underestimated the harms of antidepressants, as we only had access to the published articles for 11 of our 13 trials. Conclusions Antidepressants double the occurrence of events in adult healthy volunteers that can lead to suicide and violence.
Evaluating complex medical treatment options: a case report
Authors: Fernando Irosh , Henskens Frans , Talebian Masoud 
Published: October 2016

Objective: Complex treatment decisions can be suboptimal due to lack of a reliable decision-making model, a need this paper aims to meet. Method: A model for making complex treatment decisions is introduced. Results: The utility of the proposed method is demonstrated by making a complex treatment decision involving evaluation of clozapine treatment in a treatment-resistant patient. Conclusion: The proposed method implemented as a software tool can provide a framework for shared decision-making involving the patient.
Assessment of pedestrian discomfort glare from urban LED lighting
Authors: Villa C , Bremond R , Saint-Jacques E 
Published: October 2016

Due to different visual tasks and gaze patterns, the discomfort glare experienced by pedestrians may differ from that experienced by drivers. This paper investigates the discomfort glare experienced by pedestrians under various urban LED luminaires through psychovisual experiments conducted on a test track. The ability of state-of-the-art models to predict the level of discomfort glare, measured on the de Boer rating scale, for this application is also investigated. With one exception, the models all overestimate the mean subjective discomfort glare compared to the experimental data. Models proposed by Lin et al. (2015) and Bullough et al. (2008, 2011) perform well. However, the implementation of these models is not straightforward because choices are needed to estimate some of the variables such as the background luminance and the glare source area.
Adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital
Authors: Wahlang Julie Birdie , Laishram Purnima Devi , Brahma Dhriti Kumar , Sarkar Chayna , Lahon Joonmoni , Nongkynrih Banylla Shisha 
Published: October 2016

Background: An adverse drug reaction (ADR) is defined by World Health Organization (WHO) as ‘Any response to a drug which is noxious, unintended and occurs at doses used in man for prophylaxis, diagnosis or therapy’. ADRs associated with cancer chemotherapy warrant analysis on their severity and preventability. The outcome would create awareness among health care providers and prevent their recurrence. We have performed a hospital-based prospective observational study designed to analyze the pattern of ADRs to chemotherapeutic agents in cancer patients of a tertiary care hospital. Methods: A total of 119 cancer patients were monitored for suspected ADRs during the course of chemotherapy from November 2014 to December 2015. Clinical events were recorded and analyzed with regard to the demographics and drug details of the patients. Results: A total of 106 ADRs were recorded from 119 cases. The ADRs commonly encountered included constipation, nausea, vomiting, alopecia and hematological changes. Cisplatin, cyclophosphamide, paclitaxel and 5-FU were used for the treatment of commonly found cancers in this region affecting the lungs, esophagus and lymphomas. Naranjo’s causality assessment showed 86.7% possible (score 4) and 13.2% probable (score 5–6). Severity of adverse reactions showed 77.4% mild, 18.9% moderate and 3.8% severe. A total of 45.3% of ADRs were preventable reactions such as nausea, vomiting and constipation. Conclusions: This study highlights the role of active monitoring as an important tool for early detection, assessment and timely management of ADRs in patients undergoing cancer chemotherapy. The observed ADRs were preventable although ADRs such as hiccough, anemia, neutropenia and alopecia were not preventable.
Cognitive impairment and assistive devices: Outcomes and adverse effects
Authors: Alkadri Jamal , Jutai Jeffrey 
Published: October 2016

Purpose The goal of this review was to investigate the relationship between cognitive impairment and assistive device use in elderly persons. Methods English-language articles for people aged 65 and over were identified by searching MEDLINE and Embase (1985–June 2015) with the keywords “self-help devices” and “cognition disorders” and relevant synonyms. Bibliographies of retrieved articles were also examined; 510 articles were selected for further evaluation. Abstracts of the remaining articles were evaluated and all of the studies that concerned one or more of the following criteria were included: geriatric, long-term care residents or cognitively impaired patients using assistive devices that addressed benefits, risks, adverse effects, or other problems. Ultimately, 15 articles were analyzed and included in the review. Results Very few good-quality studies that specifically addressed the research question were found. We found that cognitively impaired elderly patients were more likely to use assistive devices ineffectively than cognitively intact elders. In addition, the literature describes promising approaches to assistive device training and technologies to accommodate cognitive impairment in this population. Conclusion The evidence basis for recommendations and training for assistive devices for cognitively impaired elders is weak. More research is needed on safety and effectiveness of devices for this population.
The Relationship Between Humeral Retrotorsion and Shoulder Range of Motion in Baseball Players With an Ulnar Collateral Ligament Tear
Authors: Lee Bobby Jean S. , Garrison J. Craig , Conway John E. , Pollard Kalyssa , Aryal Subhash 
Published: October 2016

Background: Humeral retrotorsion has been investigated in relation to shoulder range of motion (ROM) in healthy baseball players. Currently, there is limited information on the osseous anatomy and development of ulnar collateral ligament (UCL) tears. Purpose: To determine the relationship between humeral retrotorsion and shoulder ROM in baseball players with a UCL tear. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Fifty-four baseball players (mean age, 18.5 ± 2.0 years) with a UCL tear volunteered for this study. Participants were measured bilaterally for shoulder internal (IR) and external rotation (ER) ROM and humeral retrotorsion. Differences between sides (involved to uninvolved) were used to calculate the glenohumeral internal rotation deficit (GIRD), external rotation ROM difference (ERDiff), total rotational motion difference (TRM), and humeral retrotorsion difference (HTDiff). A multivariate regression analysis was performed with GIRD, ERDiff, and TRM regressing on HTDiff. Univariate analysis was performed to further evaluate the effect of the predictors on each outcome separately. To control for the effect of age, weight, duration of symptoms, and years of experience, the variables were included as covariates. An a priori level was set at P < .05. Results: There was a statistically significant relationship between the GIRD, ERDiff, and TRM results compared with HTDiff ( P = .003). Independent analysis revealed a statistically significant relationship between GIRD and HTDiff ( P = .004) and between ERDiff and HTDiff ( P = .003) but no significant relationship between TRM and HTDiff ( P = .999). After adjusting for age, weight, duration of symptoms, years of experience, dominant arm, and position, a significant relationship was found between GIRD and HTDiff ( P = .05) and between ERDiff and HTDiff ( P = .01). No significant relationship was found between TRM and HTDiff ( P = .54). Adjusted univariate regression analysis determined that HTDiff explains approximately 16% of the variance in GIRD ( r2 = 0.158) and approximately 24% of the variance in ERDiff ( r2 = 0.237). Conclusion: In baseball players with a UCL tear, approximately 16% of the variance in GIRD and 24% of the variance in ERDiff can be attributed to differences found in humeral retrotorsion between sides. This indicates that humeral retroversion contributes significantly to GIRD and increased ER ROM in baseball players. Recognition of differences in humeral retrotorsion between the dominant and nondominant upper extremities may help explain some but not all of the changes in shoulder ROM commonly seen in baseball players.
Psychoeducational Intervention to Reduce Fear of Cancer Recurrence in People at High Risk of Developing Another Primary Melanoma: Results of a Randomized Controlled Trial
Authors: Dieng Mbathio , Butow Phyllis N. , Costa Daniel S.J. , Morton Rachael L. , Menzies Scott W. , Mireskandari Shab , Tesson Stephanie , Mann Graham J. , Cust Anne E. , Kasparian Nadine A. 
Published: October 2016

Purpose People with a history of melanoma commonly report a fear of cancer recurrence (FCR), yet psychologic support is not routinely offered as part of ongoing melanoma care. This randomized controlled trial examined the efficacy of a psychoeducational intervention to reduce FCR and improve psychologic adjustment in this patient group compared with usual care. Methods The intervention comprised a newly developed psychoeducational resource and three telephone-based psychotherapeutic sessions over a 1-month period timed in accordance with dermatologic appointments. Participants were randomly assigned to intervention (n = 80) or usual care (n = 84). Assessments were completed at baseline, 1 month, and 6 months after dermatologic appointments. Linear mixed models were used to examine differences between treatment and control groups for patient-reported outcomes, including FCR, anxiety, stress, depression, melanoma-related knowledge, health behaviors, satisfaction with melanoma care, unmet needs, and health-related quality of life. Results At 6 months, the intervention group reported lower FCR severity, trigger, and distress scores than the control group in the baseline-adjusted models; the between-group mean difference was −1.9 for FCR severity (95% CI, −3.1 to −0.7; P = .002), −2.0 for FCR triggers (95% CI, −3.3 to −0.7; P = .003), and −0.7 for FCR distress (95% CI, −1.3 to −0.1; P = .03). The decrease in FCR severity (but not triggers or distress) remained statistically significant after adjustment for other covariates ( P = .04). At 6 months, the intervention group also reported lower stress (−1.6; 95% CI, −3.1 to −0.2; P = .03) and improved melanoma-related knowledge (1.7; 95% CI, 0.8 to 2.6; P < .001) compared with the control group. No differences were found between groups for other secondary outcomes. Conclusion This newly developed evidence-based psychoeducational intervention was effective in reducing FCR and stress and increasing melanoma-related knowledge in people at high risk for another melanoma.