bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Public Figures amidst Indonesia’s Early Social Restrictions Policy on Twitter (X): A Social Network Analysis
Authors: Setiadi Tatak , Pamuji Eko 
Published: October 2024

The Government of Indonesia implemented large-scale social restrictions (Indonesian: Pembatasan Sosial Berskala Besar, abbreviated as PSBB) following the first confirmed cases of COVID-19. Due to social media role in information propagation, this decision quickly became a trending topic on Twitter. This study investigates the main actors and the dynamics of these discussions surrounding PSBB. Utilizing RStudio software, tweets containing the keyword „psbb“ and the hashtag #psbb were mined as of May 6, 2020. The data were analyzed and compared with research conducted during May 2020. Key findings include the significant role of the musician Fiersa Besari in shaping discussions about social restrictions, the emergence of seven major opinion leaders, and the prominence of online news outlets like detikcom and CNN Indonesia in the conversation. Additionally, the study highlights critical commentary from actors affiliated with the Democratic Faction of the Indonesian House of Representatives regarding the government‘s social restrictions policies. These findings provide insights into the network dynamics and public opinion on social restrictions during the early social restrictions policy in Indonesia.
LEPR isoform expression changes in local fat depots in coronary atherosclerosis and acquired heart defects
Authors: Gorbatovskaya E. E. , Belik E. V. , Dyleva Yu. A. , Uchasova E. G. , Ponasenko A. V. , Fanaskova E. V. , Stasev A. N. , Gruzdeva O. V. 
Published: October 2024

Aim. To evaluate the expression of leptin receptor isoforms in local fat depots in patients with coronary artery disease (CAD) and acquired heart defects (AHDs).Material and methods. The study included 120 patients with CAD. The comparison group consisted of 96 patients with degenerative aortic stenosis (AS). Expression of six leptin receptor isoforms (LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4) was assessed using quantitative real-time polymerase chain reaction in subcutaneous (SAT), epicardial (EAT) and perivascular (PVAT) adipose tissue. Statistical processing was carried out using the Statistica 10.0 and SPSS 17.0 for Windows software package.Results. In EAT, minimal expression of LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4 was detected relative to SAT and PVAT in the group of CAD patients. In patients with CAD, mRNA levels of six LEPR isoforms were lower than in patients with AS. In indi­viduals with AHDs, a decrease in the expression of LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4 in SAT relative to EAT and PVAT was recorded. However, only the LEPR1 and LEPR2 isoforms were significantly lower in SAT in patients with AS when com­pared with patients with CAD. In PVAT, the maximum mRNA levels of six LEPR isoforms were found in both groups. There were no significant differences in LEPR1, LEPR2, LEPR2/2, LEPR3, LEPR3/2, LEPR4 expression between patients with CAD and AHDs.Conclusion. Patients with CAD are characterized by a marked decrease in the expression of six LEPR isoforms in EAT. A decrease in the expression of studied LEPR isoforms in EAT is associated with impaired adipogenesis, adipocyte hypertrophy, insulin resistance, increased proinflammatory factors, hyperleptinemia, and progression of atherosclerosis. The identified features of EAT in patients with СФВ can probably have both local and systemic negative effects on the cardiovascular system.
Atherosclerotic plaque structure according to optical coherence tomography in patients with coronary artery disease living in extreme weather conditions
Authors: Utegenov R. B. , Sapozhnikov S. S. , Bessonov I. S. 
Published: October 2024

Aim. To evaluate the plaque structural features in patients with coronary artery disease (CAD) permanently residing in the Far North of the Tyumen region in com­parison with patients in the South of the Tyumen region.Material and methods. This pilot case-control study included 32 patients with stable CAD (mean age 62,7±8,9 years, 24 (75%) men). The main group consisted of 16 patients permanently residing in the Far North of Tyumen region (non-indi­ge­nous population), while the comparison group consisted of 16 patients permanently residing in the South of the Tyumen region. In all patients, CAD was verified using paraclinical diagnostic methods. All patients underwent optical coherence tomography (OCT), according to which the plaque type was analyzed. The following plaque types were distinguished: fibrous, fibroatheroma, calcified fibroatheroma, thin-cap fibroatheroma (TCFA). TCFA was defined as the presence of a fibrous cap ≤65 μm thick and an arc of the necrotic core of at least 90о. In addition, a lipid-rich plaque was isolated, which was determined by a lipid arc of more than 180о.Results. According to clinical and angiographic characteristics, patients in the compared groups were statistically comparable. A total of 134 plaques were analyzed from 32 patients (main group — 65 plaques; control group — 69 plaques (p>0,05)). The most common plaque type in both groups was calcified fibroatheroma (46,2% in the Far North group and 50,7% in the South group, p=0,609). TCFA was significantly more often detected in patients living in far north (33,8% vs 17,4%, p=0,031). In this group of patients, thin (<65 µm) fibrous plaque cap was also more often determined (35,4% vs 18,8%, p=0,034). Lipid-rich plaques in both groups was determined with the same frequency (56,9% vs 62,3%, p=0,598).Conclusion. In patients with verified CAD living in extreme weather conditions, according to OCT, TCFA was more often determined, which could potentially be associated with a higher risk of adverse cardiovascular events.
Method of thromboembolism prediction in advanced atherosclerosis
Authors: Bykov A. V. 
Published: October 2024

Aim. To develop a method for thromboembolism prediction in patients with ad­vanced atherosclerosis.Material and methods. The study involved 170 patients with advanced atheroscle­rosis and 110 patients with local atherosclerotic lesions. At the first stage, speciali­zed experts generated signs characterizing the severity of prothrombotic conditions. To determine whether patients belonged to the first or second group, the multivariate statistics method was used. Decision rules (DRs) was developed based on soft computing (SC), as well as the methodology for the synthesis of hybrid fuzzy DRs.Results. According to the discriminant function coefficient (DFC), the division into classes was made with the formation of an intersection area, which affected the diagnostic sensitivity of this method (=86%). Due to difficulties of separating more heterogeneous groups with a small sample, RP was synthesized according to the atherosclerosis severity classification using SC technology. Atherosclerosis severity classification was adopted according to fuzzy DRs: initiation stage (up to 20%); reverse stage (21-40%); progressive stage (41-65%); critical stage (more than 65%). As­ses­sment of thromboembolism risk in advanced atherosclerosis in the examined pati­ents showed the following trends: progressive stage — 55% of patients; critical stage — 21% of patients; reverse stage — 16% of patients; initiation stage — 7% of patients.Conclusion. DFC for DRs makes it possible to identify groups with high and low thromboembolism risk. The resulting final fuzzy DRs make it possible to differentiate the atherothrombotic condition in advanced atherosclerosis by severity, which can help to timely determine preventive and therapeutic measures.
Surgical treatment of a newborn with critical aortic coarctation using palliative stenting: a case report
Authors: Lyapin A. A. , Shushpannikov P. A. , Khalivopulo I. K. , Tarasov R. S. 
Published: October 2024

Introduction. Coarctation of the aorta (CoA) is a congenital severe narrowing of the aortic isthmus, which in turn is often accompanied by impaired organ perfusion or even cardiogenic shock. In newborns with critical CoA in the case of patent ductus arteriosus (PDA) closure, the clinical condition of patients with this congenital heart defect (CHD) sharply worsens and leads to multiple organ failure. In this group of children, mortality ranges from 30 to 50% of infant mortality from CHD. This case demonstrates the positive effect of palliative stenting of a narrowed section of the aorta, which made it possible to safely perform radical surgery for CHD.Case description. Nine-year-old male patient with body weight of 3,5 kg and body length of 53 cm was admitted to the clinic with a diagnosis of CHD: Critical CoA. Secundum atrial septal defect. PDA. Multiple organ failure. Taking into account the severe comorbidity status in the form of multiple organ failure, the high risk of necrotizing enterocolitis, case conference decided to perform a step-by-step CHD treatment as follows: palliative endovascular stenting of critical CoA, followed by radical surgery after stabilization of the patient's condition. The plan was successfully implemented.Conclusion. Сritical CoA stenting can be used as a bridge to radical surgery of the defect in newborns with multiple organ failure. This palliative intervention helps to stabilize the child for up to 3 weeks and more safely perform radical surgery of CoA.
A Perspective on the Rupture States of Complex Earthquake Scenarios in the 2023 USGS Seismicity Model for the Western U.S. Faults
Authors: Mahdyiar Mehrdad 
Published: October 2024

Abstract
The 2023 U.S. Geological Survey (USGS) seismicity model for faults in the western United States (USGS-SMF-WUS) includes many earthquake scenarios (EQS) that rupture multifault sections (MFS), reflecting decades of observations that large crustal earthquakes often rupture sections of different neighboring faults in complex ways. Many of the complex MFS scenarios include rupture sections, on different faults, that are not contiguous, with spacing up to 15 km. The USGS-SMF-WUS uses an inversion methodology, referred to as magnitude-rate optimization, to optimally formulate the occurrence rates of the EQS in such a way that they collectively release the accumulating seismic moment rates on faults, at subsection level, defined by various types of geologic, geodetic, and seismologic data and constraints. This raises questions about the treatment of the MFS scenarios in the USGS-SMF-WUS regarding their rupture states and how that could potentially impact the magnitude-rate optimization and ground motions (GMs) for hazard analysis. Among many different possible rupture states for the MFS earthquakes, the two extreme scenarios could be visualized as (1) a series of noncontiguous sections rupturing in such a way that their total seismic moment and GM footprints are scaled with the sum of their rupture areas and (2) a series of noncontiguous triggered events, grouped together based on the spacing between the participating fault sections and other criteria, each releasing seismic moment and generating GM footprints that are scaled with its own rupture area. It will be shown later that the average slips on the participating sections for these two extreme rupture states would not be the same. In addition, the GM footprints from these two rupture states would be different and the differences are frequency dependent. This is especially the case when considering the complexity of rupture directivity on the participating fault sections in the USGS-SMF-WUS. It is the objective of this study to explore and discuss the implications of the triggered rupture state assumption in estimating the average slips and GM footprints of the MFS earthquakes in the USGS-SMF-WUS.
Implementation of mutual insurance “against fire” of buildings of the ecclesiastical department in Russia in 1910-1917 (based on materials from the Ust-Sysolsk Uyezd of the Vologda province)
Authors: Rozhina A. 
Published: October 2024

The paper deals with the study of the pre-revolutionary experience of mutual insurance against fires of real estate of the Russian Orthodox Church. Based on financial and office documents of the Ust-Sysolsk Uyezd of the Vologda province, the process of practical implementation of insurance of buildings of the ecclesiastical department on the principles of reciprocity is recreated.
The regulatory framework for mutual insurance was based on the legislative act of 1904, but the insurance assessment of buildings was carried out only in 1910. Information is provided on the structure of insurance documents, cases of fires and payments for damage “from fire” from sources deposited in the funds of the Russian State Historical Archive. By January 1, 1911, diocesan buildings in the Russian Empire were insured for over 800 million rubles, in the Ust-Sysolsk Uyezd – for over 859 thousand rubles. Information on the number of insured buildings and their insurance assessment, the amount of annual premiums and compensations for insurance cases in the Ust-Sysolsk Uyezd is systematized. The analyzed materials made it possible to correlate insurance premiums and insurance business costs, to access both the negative aspects and the benefits of mutual insurance for policyholders.
The author comes to the conclusion that the practices of mutual real estate insurance, organized by the Holy Synod, demonstrate valuable experience in finding solutions to eliminate material damage “from fire”, when fire losses were compensated through small contributions. Insurance on the principles of rerciprocity was most important for regional parishes, that did not have large incomes and were often unable to independantly restore destroyed buildings. Due to compensations, it was possible to repair and restore many buildings of the ecclesiastical department. Despite bureaucratic, travel, and clerical expenses for insurance business, the remaining funds allowed to form a “reserve capital”, that performed the function of a reserve fund.
Association between gut microbiome and locomotive syndrome risk in healthy Japanese adults: A cross-sectional study
Authors: Nakamura Sho , Nishiyama Minami , Matsuki Taizo , Narimatsu Hiroto 
Published: October 2024

Abstract

Japan faces challenges as a super-aging society, with increasing life expectancy and a prolonged unhealthy period burdening the social security system. Musculoskeletal dysfunction significantly contributes to this unhealthy period. While exercise may influence the gut microbiome, its role in age-related musculoskeletal decline remains unclear. This cross-sectional study used data from the Kanagawa "ME-BYO" Prospective Cohort Study to investigate the association between gut microbiome composition and musculoskeletal function. Participants with a 5-question Geriatric Locomotive Function Scale (GLFS-5) and gut microbiome data were included. Classification tree analysis was performed using GLFS-5 (≥ 6 indicating locomotive syndrome) as the objective variable. Explanatory variables included gut microbiome composition, age, sex, BMI, menopause status, medical history, nutritional intake, alcohol consumption, smoking history, physical activity, and sitting time. Among 568 participants (36.8% male, median age 58.5 years), three terminal nodes were identified as GLFS-5 positive, with one node involving gut microbiome composition. Participants aged ≥ 70.0 and < 78.0 years who did not consume probiotic foods and had ≥ 0.04% relative abundance of the Holdemania genus were classified as at risk for locomotive syndrome. This study suggests a potential association between gut microbiome composition and locomotive syndrome risk in older adults, particularly those with higher Holdemania abundance. However, the cross-sectional design limits causal inference. Further longitudinal and interventional research is needed to clarify the relationship between gut microbiome and musculoskeletal function, and to explore potential preventive strategies targeting the gut microbiome to reduce locomotive syndrome risk and extend healthy life expectancy.
Phytochemical characterization of aqueous and ethanol extracts from lime and orange rind in Guerrero, Mexico
Authors: Vazquez Jose Luis Arispe , Aguilar Rocio Toledo , Cantú David Heriberto Noriega , Victoriano Moisés Felipe , Hernández Luis Antonio Flores , Nájera Jose Francisco Díaz , Serna Sergio Arvar , Salgado José Terrones , Vidaña Mariel del Rosario Sánchez , Juárez Agustín Hernández , Hernández Juan Mayo , Zamudio Daniel Alejandro Cadena , Ramos Karla Vanessa De Lira 
Published: October 2024

Abstract

Background The phytochemicals that include both primary and secondary metabolites of the plants are of great interest in a variety of sectors, including the agricultural, pharmaceutical and cosmetic. Recently, it has been recognized that SMs could be used as a basis to develop biopesticides. The objective of this research was to identify and quantify compounds present in aqueous and ethanolic extracts from orange and lime rind from the state of Guerrero, Mexico.
Methods The objective of this study was to characterize aqueous and ethanol extracts of lime and orange rind. Lime and orange peel were collected and dried in the sun at room temperature. For characterization of plant extracts was it was done through gas chromatography-mass spectrometry (GC/MS) in an Agilent Technologies 7820A equipment, with mass selective detector (MSD, Agilent Technologies 5975), operated in the mode of complete radiofrequencies scan (full scan) in splitless mode, with an injection volume of 1 µL of sample.
Results The results from this study broaden the existing knowledge about the abundant phytochemical composition of aqueous and ethanol extracts of orange and lime. The aqueous extract of orange presented a dark brown color and the presence of 10 chemical compounds, of which D-limonene stood out as one of the predominant ones with a concentration of 95.66%, with a retention time of 4.1 min, followed by citric acid with 1.11%.
Conclusions This study represents a significant advance in the characterization and comprehension of orange and lime extracts, providing a solid base for future studies and practical applications in various scientific and commercial fields. The outstanding compounds in the extracts are D-limonene and citric acid. The continuous exploration of these compounds and their interactions promises continuing to drive discoveries that benefit both agriculture and public health globally.
Effectiveness of balloon occlusion in percutaneous transhepatic portal vein embolization with gelatin sponge: a single-institutional retrospective study
Authors: Kubo Hidemasa , Saiga Atsushi , Sato Rui , Otsuka Shimpei , Ashida Ryo , Ohgi Katsuhisa , Yamada Mihoko , Kato Yoshiyasu , Uesaka Katsuhiko , Notsu Akifumi , Sugiura Teiichi , Aramaki Takeshi 
Published: October 2024

Abstract

Background
Standard methods for percutaneous transhepatic portal vein embolization (PTPE) have not yet been established. This study aimed to elucidate the effectiveness of balloon occlusion in PTPE using gelatin sponges on the future liver remnant volume hypertrophy ratio. This retrospective study included 93 patients who underwent PTPE for right hepatectomy between January 2018 and September 2022. Based on the embolization procedure, patients were divided into balloon group (n = 13) and non-balloon group (n = 80). The clinical factors and the future liver remnant volume hypertrophy ratios were compared. Moreover, significant factors associated with the future liver remnant volume hypertrophy ratio between the groups were analyzed.
Results
The future liver remnant volume hypertrophy ratio was significantly higher in the balloon group than in the non-balloon group (1.44 [interquartile range, 1.37–1.89] vs. 1.29 [1.15–1.46], P = 0.011). The initial future liver remnant volume (289 [interquartile range, 259–454] vs. 400 [324–479] mL, P = 0.036) and number of gelatin sponge sheets (5 [interquartile range, 5–6] vs. 4 [3–5], P = 0.008) significantly differed. However, recanalization and severe complications were not different between groups. According to the multivariate linear regression analysis, diabetes mellitus (coefficient, -0.202; P = 0.009), initial future liver remnant volume (coefficient, -0.001; P < 0.001), and balloon occlusion (coefficient, 0.228; P = 0.007) were independent factors affecting the future liver remnant volume hypertrophy ratio.
Conclusion
Balloon occlusion may be effective in future liver remnant volume hypertrophy in PTPE using gelatin sponges.
Exosomes loaded Peptide Hydrogel scaffold with anti-inflammatory function and in situ stem cell recruitment properties for repairing sports-related cartilage injuries
Authors: He Jingzi , Fu Dongge , Mu Qichen , Huo Yanfang , Zhang Ningmei , Zhang Le , Hua Shu , Gao Baoquan 
Published: October 2024

Abstract

Sports-related injuries often cause damage to the articular cartilage, a structure characterized by the absence of blood vessels, nerves, and lymphatics, which hinders its ability to heal. Current clinical interventions fall short in reversing cartilage degeneration or regenerating fibrocartilage, leading to less than satisfactory outcomes. Furthermore, the use of hydrogel-based stem cell therapies has been hampered by the poor survival of transplanted stem cells in the inflamed environment of the injured cartilage, and by the uncontrolled differentiation of these cells due to cytokines, limiting their clinical application. In our study, we developed a novel approach using a biodegradable peptide hydrogel that incorporates anti-inflammatory exosomes known to stimulate stem cell growth and peptides that recruit endogenous stem cells to the site of injury. This system sidesteps the need for exogenous stem cells by utilizing the body's own healing mechanisms, guided by specific peptides. Once at the site of injury, these stem cells are stimulated to differentiate into cartilage tissue through a combination of TGF-β1 and the exosomes, which also help to suppress inflammation and promote healing. This research offers a promising new strategy for treating sports-related cartilage injuries, presenting a more effective and less invasive option for patients.