bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome Sequences of Salmonella enterica subsp.
enterica
Serovar Lubbock Strains Isolated from Liver Abscesses of Feedlot Cattle
Authors: Amachawadi Raghavendra G. , Thomas Milton , Nagaraja Tiruvoor G. , Scaria Joy 
Published: May 2016

ABSTRACT

The genome sequencing of 13
Salmonella enterica
subsp.
enterica
serovar Lubbock strains isolated from liver abscesses of feedlot cattle is reported here. The availability of these genomes will help to further understand the etiologic role of
Salmonella
strains in liver abscesses of cattle and will serve as references in microbial trace-back studies to improve food safety.
Genome Sequence of the Banana Plant Growth-Promoting Rhizobacterium Pseudomonas fluorescens PS006
Authors: Gamez Rocío M. , Rodríguez Fernando , Ramírez Sandra , Gómez Yolanda , Agarwala Richa , Landsman David , Mariño-Ramírez Leonardo 
Published: May 2016

ABSTRACT

Pseudomonas fluorescens
is a well-known plant growth-promoting rhizobacterium (PGPR). We report here the first whole-genome sequence of PGPR
P. fluorescens
evaluated in Colombian banana plants. The genome sequences contains genes involved in plant growth and defense, including bacteriocins, 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, and genes that provide resistance to toxic compounds.
Genome Sequence of Riemerella anatipestifer Strain RCAD0122, a Multidrug-Resistant Isolate from Ducks
Authors: Song Xiao-Heng , Zhou Wang-Shu , Wang Jiang-Bo , Liu Ma-Feng , Wang Ming-Shu , Cheng An-Chun , Jia Ren-Yong , Chen Shun , Sun Kun-Feng , Yang Qiao , Wu Ying , Chen Xiao-Yue , Zhu De-Kang 
Published: May 2016

ABSTRACT

Riemerella anatipestifer
is an important pathogenic bacterium in waterfowl and other avian species. We present here the genome sequence of
R. anatipestifer
RCAD0122, a multidrug-resistant strain isolated from infected ducks. The isolate contains at least nine types of antibiotic resistance-associated genes.
Draft Genome Sequence of
Pseudomonas
sp. EpS/L25, Isolated from the Medicinal Plant
Echinacea purpurea
and Able To Synthesize Antimicrobial Compounds
Authors: Presta Luana , Bosi Emanuele , Fondi Marco , Maida Isabel , Perrin Elena , Miceli Elisangela , Maggini Valentina , Bogani Patrizia , Firenzuoli Fabio , Di Pilato Vincenzo , Rossolini Gian Maria , Mengoni Alessio , Fani Renato 
Published: May 2016

ABSTRACT

We announce here the draft genome sequence of
Pseudomonas
sp. strain EpS/L25, isolated from the stem/leaves of the medicinal plant
Echinacea purpurea
. This genome will allow for comparative genomics in order to identify genes associated with the production of bioactive compounds and antibiotic resistance.
Genome Sequence of the Multiantibiotic-Resistant Enterococcus faecium Strain C68 and Insights on the pLRM23 Colonization Plasmid
Authors: García-Solache Mónica , Rice Louis B. 
Published: May 2016

ABSTRACT

Enterococcus faecium
infections are a rising concern in hospital settings. Vancomycin-resistant enterococci colonize the gastrointestinal tract and replace nonresistant strains, complicating the treatment of debilitated patients. Here, we present a polished genome of the multiantibiotic-resistant strain C68, which was obtained as a clinical isolate and is a useful experimental strain.
Draft Genome Sequence of Vancomycin-Susceptible, Ampicillin-Intermediate Enterococcus faecium Strain D344RRF
Authors: García-Solache Mónica , Rice Louis B. 
Published: May 2016

ABSTRACT

Enterococcus faecium
is an important nosocomial pathogen, causing a substantial health burden due to high resistance to antibiotics and its ability to colonize the gastrointestinal tract. Here, we present the draft genome of vancomycin-susceptible, ampicillin-intermediate strain D344RRF, a rifampicin/fusidic acid-resistant and commonly used laboratory strain, which is useful in studying the transfer of antibiotic resistance.
A customised ENT admissions proforma and novel online ‘clerking collaborative’
Authors: Hariri Ahmad A , Edmiston Rachel , Mani Navin , Lloyd Simon K 
Published: May 2016

ObjectivesAdmissions clerking proformas are commonly used in hospitals to aid complete patient assessment. Much variation remains in the format of these forms and they frequently fail to account for local-specific and specialty-specific factors. We developed and piloted the use of a novel ear, nose and throat (ENT) clinic admissions clerking proforma and created a national online ‘clerking collaborative’.MethodsDoctors completed ‘mock clerkings’ for 6 common acute ENT presentations by both traditional methods (freehand) and using our customised ENT diagrams. Participants were timed throughout the process and asked to complete a feedback survey. A senior ENT clinician provided structured feedback comparing the quality of each type of clerking.Results9 junior doctors participated in the exercise. 5 participants started with freehand drawings while the remainder used our clerking proforma first. Our customised diagrams provided accurate representations of the clinical scenarios, and were easier and faster to complete than free drawings. They were also easier to interpret and best represented the clinical findings compared with freehand clerkings. A website (MyClerking.co.uk) was created to disseminate the clerking proforma and to allow other clinicians to contribute improvements.ConclusionsAccurate and legible clerkings are essential to allow for continuity of care and management. This is particularly important in ENT, where drawings are frequently used to describe clinical findings. Our predrawn diagrams speed up the clerking process and allow for more accurate depiction of findings. We have designed an online ‘clerking collaborative’ where doctors can download our proforma, contribute improvements and upload their own ideas for other specialties.
Primary care interventions to improve transition of youth with chronic health conditions from paediatric to adult healthcare: a systematic review
Authors: Bhawra Jasmin , Toulany Alene , Cohen Eyal , Moore Hepburn Charlotte , Guttmann Astrid 
Published: May 2016

ObjectiveTo determine effective interventions to improve primary care provider involvement in transitioning youth with chronic conditions from paediatric to adult care.DesignSystematic review. Multiple electronic databases were searched including Ovid MEDLINE, EMBASE and Web of Science (from 1 January 1947 to 5 August 2015). Evidence quality was assessed using a 36-point scoring system for disparate study designs.SettingStudies with paediatric-to-adult transition programmes and interventions involving primary care providers or in primary care settings.ParticipantsYouth aged 16 years and over.OutcomesRelevant outcomes were grouped into 3 main domains based on the Triple Aim Framework: experience of care, population health, cost.ResultsA total of 1888 unique citations were identified, yielding 3 studies for inclusion. Overall, primary care provider roles were not well defined. 2 studies used case managers to facilitate referrals to primary care, and the remaining study was the only 1 situated in a primary care setting. None of the studies examined transition in all 3 Triple Aim Framework domains. The most commonly reported outcomes were in the cost domain.ConclusionsThere is limited empiric evidence to guide primary care interventions to improve transition outcomes for youth with chronic conditions. Future research and policy should focus on developing and evaluating coordinated transition interventions to better integrate primary care for high need populations.
How can we help family carers manage pain medicines for patients with advanced cancer? A systematic review of intervention studies
Authors: Latter Sue , Hopkinson Jane B , Richardson Alison , Hughes Jane A , Lowson Elizabeth , Edwards Deborah 
Published: May 2016

BackgroundFamily carers play a significant role in managing pain and associated medicines for people with advanced cancer. Research indicates that carers often feel inadequately prepared for the tasks involved, which may impact on carers’ and patients’ emotional state as well as the achievement of optimal pain control. However, little is known about effective methods of supporting family carers with cancer pain medicines.AimsTo systematically identify and review studies of interventions to help carers manage medicines for pain in advanced cancer. To identify implications for practice and research.MethodA systematic literature search of databases (MEDLINE, CINAHL, PsycINFO and AMED) was carried out to identify studies of pain medication management interventions that involved family carers of patients with advanced cancer, and reported specific outcomes for family carers. Patient pain outcomes were also sought. Studies were quality appraised; key aspects of study design, interventions and outcomes were compared and a narrative synthesis of findings developed.Results8 studies were included; all had significant methodological limitations. The majority reported improvements in family carer knowledge and/or self-efficacy for managing pain medicines; no effect on patient pain outcomes; and no adverse effects. It was not possible to discern any association between particular intervention characteristics and family carer outcomes.ConclusionsCurrent evidence is limited, but overall suggests face-to-face educational interventions supported by written and/or other resources have potential to improve carers’ knowledge and self-efficacy for pain management. Further research is needed to identify how best to help family carers manage pain medicines for patients with advanced cancer.
Hospital Variation in Premature Clopidogrel Discontinuation After Drug‐Eluting Stent Placement in the Veterans Affairs (VA) Healthcare System
Authors: Vigen Rebecca , Maddox Thomas M. , O'Donnell Colin I. , Grunwald Gary K. , Bhatt Deepak L. , Tsai Thomas T. , Rumsfeld John S. , Ho P. Michael 
Published: May 2016

Background

Premature clopidogrel discontinuation after drug‐eluting stent placement is associated with adverse outcomes. Little is known about patient and hospital factors associated with premature discontinuation or whether less variation in premature discontinuation exists in integrated health care systems such as the
Veterans Affairs
(VA).

Methods and Results

We evaluated the frequency of premature clopidogrel discontinuation, defined as a gap between clopidogrel refills of ≥90 days during the first 6 months of treatment, among 12 707 patients who received drug‐eluting stents in
VA
hospitals between 2008 and 2010. We evaluated the association between premature discontinuation and all‐cause mortality and/or acute myocardial infarction, variation in the proportion of premature discontinuation among hospitals, the patient and hospital characteristics associated with premature discontinuation, and the extent to which unexplained hospital characteristics contribute to premature discontinuation. Of the patients, 963 (7.6%) discontinued clopidogrel prematurely. Premature discontinuation was associated with acute myocardial infarction and all‐cause mortality (hazard ratio 1.65, 95% CI 1.37–1.99,
P
<0.001). The proportion of patients with premature discontinuation varied across hospitals from 0% to 16.5% (
P
<0.001). We found a median of 24% greater odds of patients with identical covariates with premature discontinuation at one randomly selected hospital compared with another (median odds ratio 1.24, 95% CI 1.17–1.44). Patient factors associated with premature discontinuation included lack of cardiology follow‐up within 30 days of discharge and smaller initial clopidogrel fill.

Conclusion
One in 13 patients prematurely discontinued clopidogrel, and variation in discontinuation across hospitals was observed. Patient factors were associated with premature discontinuation that may represent targets for quality improvement.
Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale
Authors: Agis Daniel , Goggins Maria B. , Oishi Kumiko , Oishi Kenichi , Davis Cameron , Wright Amy , Kim Eun Hye , Sebastian Rajani , Tippett Donna C. , Faria Andreia , Hillis Argye E. 
Published: May 2016

Background and Purpose—
The National Institutes of Health Stroke Scale (NIHSS) includes minimal assessment of cognitive function, particularly in right hemisphere (RH) stroke. Descriptions of the Cookie Theft picture from the NIHSS allow analyses that (1) correlate with aphasia severity and (2) identify communication deficits in RH stroke. We hypothesized that analysis of the picture description contributes valuable information about volume and location of acute stroke.

Methods—
We evaluated 67 patients with acute ischemic stroke (34 left hemisphere [LH]; 33 RH) with the NIHSS, analysis of the Cookie Theft picture, and magnetic resonance imaging, compared with 35 sex- and age-matched controls. We evaluated descriptions for total content units (CU), syllables, ratio of left:right CU, CU/minute, and percent interpretive CU, based on previous studies. Lesion volume and percent damage to regions of interest were measured on diffusion-weighted imaging. Multivariable linear regression identified variables associated with infarct volume, independently of NIHSS score, age and sex.

Results—
Patients with RH and LH stroke differed from controls, but not from each other, on CU, syllables/CU, and CU/minute. Left:right CU was lower in RH compared with LH stroke. CU, syllables/CU, and NIHSS each correlated with lesion volume in LH and RH stroke. Lesion volume was best accounted by a model that included CU, syllables/CU, NIHSS, left:right CU, percent interpretive CU, and age, in LH and RH stroke. Each discourse variable and NIHSS score were associated with percent damage to different regions of interest, independently of lesion volume and age.

Conclusions—
Brief picture description analysis complements NIHSS scores in predicting stroke volume and location.
Comparison of Climate Response to Anthropogenic Aerosol versus Greenhouse Gas Forcing: Distinct Patterns
Authors: Wang Hai , Xie Shang-Ping , Liu Qinyu 
Published: May 2016

Abstract
Spatial patterns of climate response to changes in anthropogenic aerosols and well-mixed greenhouse gases (GHGs) are investigated using climate model simulations for the twentieth century. The climate response shows both similarities and differences in spatial pattern between aerosol and GHG runs. Common climate response between aerosol and GHG runs tends to be symmetric about the equator. This work focuses on the distinctive patterns that are unique to the anthropogenic aerosol forcing. The tropospheric cooling induced by anthropogenic aerosols is locally enhanced in the midlatitude Northern Hemisphere with a deep vertical structure around 40°N, anchoring a westerly acceleration in thermal wind balance. The aerosol-induced negative radiative forcing in the Northern Hemisphere requires a cross-equatorial Hadley circulation to compensate interhemispheric energy imbalance in the atmosphere. Associated with a southward shift of the intertropical convergence zone, this interhemispheric asymmetric mode is unique to aerosol forcing and absent in GHG runs. Comparison of key climate response pattern indices indicates that the aerosol forcing dominates the interhemispheric asymmetric climate response in historical all-forcing simulations, as well as regional precipitation change such as the drying trend over the East Asian monsoon region. While GHG forcing dominates global mean surface temperature change, its effect is on par with and often opposes the aerosol effect on precipitation, making it difficult to detect anthropogenic change in rainfall from historical observations.
Physiological Motion Axis for the Seat of a Dynamic Office Chair
Authors: Kuster Roman Peter , Bauer Christoph Markus , Oetiker Sarah , Kool Jan 
Published: May 2016

Objective The aim of this study was to determine and verify the optimal location of the motion axis (MA) for the seat of a dynamic office chair. Background A dynamic seat that supports pelvic motion may improve physical well-being and decrease the risk of sitting-associated disorders. However, office work requires an undisturbed view on the work task, which means a stable position of the upper trunk and head. Current dynamic office chairs do not fulfill this need. Consequently, a dynamic seat was adapted to the physiological kinematics of the human spine. Method Three-dimensional motion tracking in free sitting helped determine the physiological MA of the spine in the frontal plane. Three dynamic seats with physiological, lower, and higher MA were compared in stable upper body posture (thorax inclination) and seat support of pelvic motion (dynamic fitting accuracy). Spinal kinematics during sitting and walking were compared. Results The physiological MA was at the level of the 11th thoracic vertebra, causing minimal thorax inclination and high dynamic fitting accuracy. Spinal motion in active sitting and walking was similar. Conclusion The physiological MA of the seat allows considerable lateral flexion of the spine similar to walking with a stable upper body posture and a high seat support of pelvic motion. Application The physiological MA enables lateral flexion of the spine, similar to walking, without affecting stable upper body posture, thus allowing active sitting while focusing on work.
Consideration of Insulin Pumps or Continuous Glucose Monitors by Adolescents With Type 1 Diabetes and Their Parents
Authors: Wysocki Tim , Hirschfeld Fiona , Miller Louis , Izenberg Neil , Dowshen Steven A. , Taylor Alex , Milkes Amy , Shinseki Michelle T. , Bejarano Carolina , Kozikowski Chelsea , Kowal Karen , Starr-Ashton Penny , Ross Judith L. , Kummer Mark , Carakushansky Mauri , Lyness D’Arcy , Brinkman William , Pierce Jessica , Fiks Alexander , Christofferson Jennifer , Rafalko Jessica , Lawson Margaret L. 
Published: May 2016

Purpose This article describes the stakeholder-driven design, development, and testing of web-based, multimedia decision aids for youth with type 1 diabetes who are considering the insulin pump or continuous glucose monitoring and their parents. This is the initial phase of work designed to develop and evaluate the efficacy of these decision aids in promoting improved decision-making engagement with use of a selected device. Methods Qualitative interviews of 36 parents and adolescents who had previously faced these decisions and 12 health care providers defined the content, format and structure of the decision aids. Experts in children’s health media helped the research team to plan, create, and refine multimedia content and its presentation. A web development firm helped organize the content into a user-friendly interface and enabled tracking of decision aid utilization. Throughout, members of the research team, adolescents, parents, and 3 expert consultants offered perspectives about the website content, structure, and function until the design was complete. Results With the decision aid websites completed, the next phase of the project is a randomized controlled trial of usual clinical practice alone or augmented by use of the decision aid websites. Conclusions Stakeholder-driven development of multimedia, web-based decision aids requires meticulous attention to detail but can yield exceptional resources for adolescents and parents contemplating major changes to their diabetes regimens.
Sphenopalatine ganglion stimulation in cluster headache and other types of headache
Authors: Láinez Miguel JA , Marti Ana Suller 
Published: May 2016

Objectives The cluster headache is the most excruciatingly painful primary headache. In some patients, neither preventive treatment nor acute treatment is effective or treatment is poorly tolerated. The sphenopalatine ganglion (SPG) has an important role in the pathophysiology of cluster headache and, for this reason, SPG stimulation has been used to treat cluster headache. Methods We have reviewed the published literature on the role of the SPG in cluster headache and the use of different treatments targeting the SPG. Results Multiple procedures have been used over the SPG to treat pain and trigemino-autonomic symptoms in patients with refractory cluster headache. After obtaining good results in a small number of patients, a miniaturized stimulator was developed. Stimulation of the SPG with this device proved to be efficacious in acute and preventive treatment in a clinical trial involving patients with chronic refractory cluster headache. Implantation of the device is minimally invasive and the most frequent side-effects are mild, such as paraesthesia and pain over the maxillary area. In patients who have used the SPG device for longer than one year, the therapeutic effect remains effective and the side-effects decrease. Conclusions The reported studies have demonstrated that SPG stimulation is a safe and effective treatment for chronic cluster headache. Long-term studies have shown that the effect remains over time and this treatment could be a good choice in patients with chronic refractory headache. We need more data about its potential use in other forms of headache, such as other trigemino-autonomic headaches or migraine.
Physiological and psychological factors associated with onset of high-altitude headache in Chinese men upon acute high-altitude exposure at 3700 m
Authors: Guo Wen-Yun , Bian Shi-Zhu , Zhang Ji-Hang , Li Qian-ning , Yu Jie , Chen Jian-Fei , Tang Cai-Fa , Rao Rong-Sheng , Yu Shi-Yong , Jin Jun , Huang Lan 
Published: May 2016

Aim We aimed to identify clinical characteristics and risk factors associated with onset of high-altitude headache (HAH) after acute exposure at 3700 m. Method In two hours, 163 individuals ascended by plane to 3700 m. Demographic information, physiological and psychological measurements, cognitive function, physical work capacity tests and profile of mood states within one week prior to the departure and within 24 hours after arrival were examined. Results HAH patients featured significantly higher vertebral artery diastolic velocity (Vd), heart rate (HR) and pulmonary artery diameter. HAH was also associated with a more negative mood state, including scores for tension anxiety, depression, hostility, fatigue and confusion, as well as lower vigor (all p values <0.05). Furthermore, negative emotions were positively related to HAH severity. HAH slightly decreased cognitive functioning. HR, Vd, lack of vigor, confusion and self-reported anxiety (all p values <0.05) were independent risk factors for HAH. We have identified three independent baseline predictors for HAH including internal diameter of the left ventricle (LVD), Athens Insomnia Scale (AIS) and confusion score. Conclusions Higher HR, Vd, confusion and self-reported anxiety and insufficient vigor were independent risk factors for HAH. Furthermore, higher baseline LVD, AIS and confusion score are independent predictors of HAH.