bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synovial sarcoma of the ethmoid sinus with extension to the cavernous sinus: a case report and literature review
Authors: Sharabati Haneen H , Innab Laila R , Hussein Saja S , Salman Ayman A , Naser Anis M , Bakri Izzeddin A 
Published: October 2024

Abstract
Synovial sarcomas are rare soft tissue tumors primarily affecting the extremities but can occasionally manifest in unusual locations such as the ethmoid sinus, posing diagnostic challenges. We present a case of a 38-year-old male with a 7-month history of recurrent throbbing headaches, left eye pain, and facial nerve palsy, evolving into multiple stroke episodes. Radiological studies showed extension to the cavernous sinus, raising an initial suspicion of vasculitis. Histological findings of an endoscopic biopsy, however, confirmed a monophasic synovial sarcoma. The patient was referred to a specialized center for further management. Unfortunately, he developed another stroke before receiving treatment. Management included chemotherapy and definitive radiation therapy targeting the ethmoid sinus. The patient is currently receiving ongoing palliative care for symptom management. This case underscores the importance of early diagnosis and a multidisciplinary approach in managing rare and aggressive tumors such as synovial sarcoma of the ethmoid sinus.
Revisiting the early light-induced protein hypothesis in the sustained thermal dissipation mechanism in yew leaves
Authors: Ye Zihao , Sawada Mina , Iwasa Makiko , Moriyama Ryo , Dey Debayan , Furutani Miyu , Kitao Mitsutoshi , Hara Toshihiko , Tanaka Ayumi , Kishimoto Junko , Yokono Makio , Akimoto Seiji , Takabayashi Atsushi , Tanaka Ryouichi 
Published: October 2024

Abstract
Overwintering evergreen trees in boreal regions continuously convert absorbed light energy into heat through a process known as sustained thermal dissipation. To better understand this mechanism, this study examined the alterations in the photosynthetic apparatus and transcriptomes of yew (Taxus cuspidata) leaves throughout the year, comparing sun-exposed and shaded leaves. The Y(II) parameter, conventionally used to estimate the quantum yield of photosystem II (PSII), indicated the occurrence of temperature-dependent thermal dissipation during winter. On the other hand, the levels of photosystem subunits, including the D1 subunit of the PSII reaction center, remained relatively stable year-round, indicating that typical photoinhibition is unlikely to occur. Time-resolved chlorophyll fluorescence analysis revealed that heat dissipation at the PSII antenna is prominent in winter. Winter transcriptomes are notably characterized by a predominance of Elip transcripts encoding early light-induced protein (ELIP), which constitute 20% of the total transcripts, as deduced from RNA-seq analysis. Furthermore, ELIP protein concentration increased to nearly half that of the major light-harvesting complexes. The predicted structure of ELIP includes potential chlorophyll a and carotenoid binding sites. These findings, taken together with a previous report showing ELIP capacity for energy dissipation, lead to a re-evaluation of its significant role in sustained thermal dissipation.
Alleviating the Hubble tension using the Barrow holographic dark energy cosmology with Granda–Oliveros IR cut-off
Authors: Yarahmadi M , Salehi A 
Published: October 2024

ABSTRACT
In this study, we investigate the Barrow holographic dark energy (BHDE) model with the Granda–Oliveros(G–O) infrared (IR) cut-off in the presence of neutrino masses, utilizing the latest observational data to address the Hubble tension. The GO cut-off is defined as $L_{\mathrm{ IR}}=(\alpha H^2 + \beta \dot{H})^{-1/2}$. We place constraints on the total neutrino mass $\sum m_{\nu }$ using data from Type Ia supernovae (SN) Pantheon, cosmic chronometers (CC), cosmic microwave background (CMB), Baryon Acoustic Oscillation (BAO) data sets, and Planck Lensing. Specifically, the comprehensive CMB + BAO + CC + Pantheon data set provides a total neutrino mass of $0.118\, \text{eV}$. The parameters for the Barrow-GO model are determined to be $\Delta = 0.0055^{+0.0086}_{-0.0086}$, $\alpha = 0.997^{+0.060}_{-0.060}$, and $\beta = 0.598^{+0.080}_{-0.080}$, showing good agreement with previous studies. One of the key findings of this study is the model’s ability to alleviate the Hubble tension, as evidenced by the comparison of $H_0$ measurements. Specifically, the tension value for the combination of data set (CMB + BAO + CC + Pantheon + Lensing) is $1.5\sigma$ with the Planck 2018 and $1.4\sigma$ with R22. These results underscore the importance of multi-data set integration in refining constraints on neutrino properties and highlight the model’s efficacy in probing fundamental aspects of neutrino physics. Our results demonstrate that the BHDE model with the GO cut-off can effectively address the Hubble tension, offering a coherent framework that reconciles local and cosmological measurements of the Hubble constant.
Asteroseismology of the mild Am δ Sct star HD 118660: TESS photometry and modelling
Authors: Sarkar Mrinmoy , Joshi Santosh , Dupret Marc-Antoine , Trust Otto , De Cat Peter , Semenko Eugene , Lampens Patricia , Goswami Aruna , Mkrtichian David , Karinkuzhi Drisya , Yakunin Ilya , Gupta Archana 
Published: October 2024

ABSTRACT
We present the results of an asteroseismic study of HD 118660 (TIC 171729860), being a chemically peculiar (mild Am) star exhibiting $\delta$ Scuti ($\delta$ Sct) pulsations. It is based on the analysis of two sectors of time-series photometry from the space mission TESS (Transiting Exoplanet Survey Satellite) and seismic modelling. It yielded the detection of 15 and 16 frequencies for TESS sectors 23 and 50, respectively. The identified pulsation modes include four radial ($\ell =0$) and five dipolar ($\ell =1$) ones. The radial modes are overtones with order n ranging from 3 and 6. Such high values of n are theoretically not expected for stars with the effective temperature of HD 118660 ($T_{\rm eff}\approx 7550\,\rm K$) located near the red edge of the $\delta$ Sct instability strip. To estimate the asteroseismic parameters, we have generated a grid of stellar models assuming a solar metallicity ($Z=0.014$) and different values for the convective overshooting parameter ($0.1\le \alpha _{\rm ov}\le 0.3$). We conclude that the analysis of the radial modes is insufficient to constrain $\alpha _{\rm ov}$ and Z for $\delta$ Sct stars. The value for the equatorial velocity of HD 118660 derived from the seismic radius and the rotational frequency is consistent with values found in the literature.
STK19 is a transcription-coupled repair factor that participates in UVSSA ubiquitination and TFIIH loading
Authors: Tan Yuanqing , Gao Meng , Huang Yanchao , Zhan Delin , Wu Sizhong , An Jiao , Zhang Xiping , Hu Jinchuan 
Published: October 2024

Abstract
Transcription-coupled repair (TCR) is the major pathway to remove transcription-blocking lesions. Although discovered for nearly 40 years, the mechanism and critical players of mammalian TCR remain unclear. STK19 is a factor affecting cell survival and recovery of RNA synthesis in response to DNA damage, however, whether it is a necessary component for TCR is unknown. Here, we demonstrated that STK19 is essential for human TCR. Mechanistically, STK19 is recruited to damage sites through direct interaction with CSA. It can also interact with RNA polymerase II in vitro. Once recruited, STK19 plays an important role in UVSSA ubiquitination which is needed for TCR. STK19 also promotes TCR independent of UVSSA ubiquitination by stimulating TFIIH recruitment through its direct interaction with TFIIH. In summary, our results suggest that STK19 is a key factor of human TCR that links CSA, UVSSA ubiquitination and TFIIH loading, shedding light on the molecular mechanisms of TCR.
Spatially restricted ecto‐5′‐nucleotidase expression promotes the growth of uterine leiomyomas by modulating Akt activity
Authors: Guo Xiaofang , Okuka Maja , Short Brittney , Ozmen Asli , Gunay Nihan Semerci , Rymer Jake , Un Burak , Guzeloglu‐Kayisli Ozlem , Rutherford Thomas J. , Kayisli Umit , Anderson Matthew L. 
Published: October 2024

AbstractFound in as many as 80% of women, uterine leiomyomas are a frequent cause of abnormal uterine bleeding, pelvic pain, and infertility. Despite their significant clinical impact, the mechanisms responsible for driving leiomyoma growth remain poorly understood. After obtaining IRB permission, expression of ecto‐5′‐nucleotidase (NT5E, CD73) was assessed in matched specimens of myometrium and leiomyoma by real‐time qPCR, Western blot, and immunohistochemistry (IHC). Adenosine concentrations were measured by enzyme‐linked assay. Primary cultures were used to assess the impact of adenosine and/or adenosine receptor agonists on proliferation, apoptosis, and patterns of intracellular signaling in vitro. When compared to matched specimens of healthy myometrium, uterine leiomyomas were characterized by reduced CD73 expression. Largely limited to thin‐walled vascular structures and the pseudocapsule of leiomyomas despite diffuse myometrial distribution. Restricted intra‐tumoral CD73 expression was accompanied by decreased levels of intra‐tumoral adenosine. In vitro, incubation of primary leiomyoma cultures with adenosine or its hydrolysis‐resistant analog 2‐chloro‐adenosine (2‐CL‐AD) inhibited proliferation, induced apoptosis, and reduced proportion of myocytes in S‐ and G2‐M phases of the cell cycle. Decreased proliferation was accompanied by reduced expression of phospho‐Akt, phospho‐Cdk2‐Tyr15, and phospho‐Histone H3. Enforced expression of the A2B adenosine receptor (ADORA2B) and ADORA2B‐selective agonists similarly suppressed proliferation and inhibited Akt phosphorylation. Collectively, these observations broadly implicate CD73 and reduced extracellular concentrations of adenosine as key regulators of leiomyoma growth and potentially identify novel strategies for clinically managing these common tumors.
Removal of Retro-Corporeal Compressive Pathology Using Guttering Osteotomy During Anterior Cervical Discectomy and Fusion
Authors: Lee Dong-Ho , Hwang Chang Ju , Cho Jae Hwan , Park Sehan 
Published: October 2024

Study Design:
A retrospective cohort study.

Objective:
Guttering is a technique that creates a tunnel through the vertebral body adjacent to the endplate to remove compressive pathologies behind the vertebral body during anterior cervical discectomy and fusion (ACDF). In this study, we investigated cases of patients who underwent gutter-shaped osteotomy (guttering) to decompress retro-corporeal compressive lesions.

Summary of Background Data:
Retro-corporeal pathologies causing cord compression cannot be removed using conventional ACDF.

Materials and Methods:
A total of 217 patients who underwent ACDF to treat cervical myelopathy and were followed up for ≥1 year were retrospectively reviewed. The fusion rate, subsidence, neck pain visual analog scale (VAS), arm pain VAS, and neck disability index (NDI) were assessed. Results were compared between the guttering (patients for whom guttering was performed) and nonguttering (patients for whom guttering was not performed) groups.

Results:
Thirty-five patients (16.1%) were included in the guttering group, while 182 patients (83.8%) were included in the nonguttering group. Fusion rates assessed by interspinous motion (P=0.559) and bone bridging on computed tomography (CT) (P=0.541 and 0.715, respectively) were not significantly different between the 2 groups at 1 year after surgery. Furthermore, neck pain VAS (P=0.492), arm pain VAS (P=0.099), and NDI (P=1.000) 1 year after surgery did not demonstrate significant intergroup differences. All patients in the guttering group exhibited healed guttering on 1-year postsurgery CT.

Conclusions:
Guttering as an adjunct to ACDF could provide a more expansive workspace for complete decompression when compressive pathology extends retrocorporeal. This additional bone resection is not associated with increased pseudarthrosis or subsidence or related to aggravation of patient symptoms.

Level of Evidence:
Level III.
Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study
Authors: Worm Jacob , Jørgensen Isabella Friis , Davídsson Ólafur Birgir , Hjalgrim Henrik , Röder Timo , Ostrowski Sisse Rye , Pedersen Ole Birger , Erikstrup Christian , Bruun Mie Topholm , Jensen Bitten Aagaard , Sørensen Erik , Ullum Henrik , Björnsdóttir Gyða , Thorgeirsson Thorgeir , Stefánsson Hreinn , Sveinsson Ólafur Árni , Stefánsson Kári ,   DBDS Genomic Consortium, Schytz Henrik Winther , Bendtsen Lars , Brunak Søren , Hansen Thomas Folkmann , Maarbjerg Stine 
Published: October 2024

Abstract
There is a limited understanding of risk factors and comorbidities in trigeminal neuralgia, a disease characterized by paroxysms of severe unilateral facial pain and a higher incidence in women. We aim to identify temporally associated comorbidities involving trigeminal neuralgia by analyzing nationwide disease trajectories. Using data from 7.2 million unique individuals in the Danish National Patient Register between 1994 and 2018, each individual diagnosed with trigeminal neuralgia was compared with 10,000 matched controls to identify co-occurring diseases. The sequential disease associations were identified in sex-stratified disease trajectories. A Cox-regression analysis investigated whether treatment with carbamazepine or oxcarbazepine, as compared with gabapentin, pregabalin, or lamotrigine, was associated with stroke risk. Finally, we investigated the stroke polygenic risk score and its association with stroke incidence in a subset of genotyped individuals with trigeminal neuralgia. We included 7141 individuals with trigeminal neuralgia (64.2% female, mean age at diagnosis 58.7 years) and identified 18 diseases associated with subsequent trigeminal neuralgia. After diagnosis, trigeminal neuralgia was associated with 9 diseases, including ischemic stroke (relative risk 1.55). Carbamazepine or oxcarbazepine treatment increased the ischemic stroke risk (hazard ratio 1.78; 95% confidence interval 1.47-2.17); however, the polygenic risk of stroke showed no association. In the Danish population, a trigeminal neuralgia diagnosis is temporally associated with 27 diseases revealed in systematic disease trajectories. Trigeminal neuralgia itself and its first-line treatment, but not a stroke polygenic risk score, was associated with an increased risk of ischemic stroke indicating that vascular risk factors should be routinely assessed in individuals with trigeminal neuralgia.
Integrating Evidence-Based Screening, Brief Intervention, and Referral to Treatment Into a Family Nurse Practitioner Program
Authors: Fetterhoff Kelly , Kuhns Kelly , Minter Cayleigh 
Published: October 2024

Abstract
Screening, Brief Intervention, and Referral to Treatment (SBIRT) is used to screen for substance use, provide a brief intervention, and refer patients with consequential substance use for treatment. Over the past decade, consequential substance use and substance use-related deaths have dramatically increased. SBIRT has been implemented in a variety of settings across the world as a strategy to decrease substance use and prevent further deaths.

Problem Statement
Substance use disorder (SUD)—and more specifically opioid use disorder—is a national epidemic. With the increasing amounts of people suffering from SUD, all healthcare professionals should be educated to identify substance abuse, provide a brief intervention, and refer patients for treatment when indicated.

Purpose
The purpose of this project is to integrate the SBIRT into the curriculum of a graduate-level family nurse practitioner (FNP) program in southeastern Pennsylvania and to determine if educating FNP students on the SBIRT process increases their knowledge of SUDs and their treatment and increases their motivation to work with patients with SUD.

Measurements
The measurements used were as follows: shortened Alcohol and Alcohol Problems Perception Questionnaire (S-AAPPQ), shortened Drug and Drug Problems Perception Questionnaire (S-DDPPQ), a 10-question knowledge test, and demographic data.

Results
All subscales of the S-DDPPQ, the S-AAPPQ, and the knowledge test showed a statistically significant change from the pretest score means and to posttest means. This evidence-based practice project supports the integration of SBIRT education into FNP programs to increase their ability to identify and treat individuals with SUDs.
Importance of a thorough history and physical examination: Case report of atypical necrotizing fasciitis
Authors: Costa-Pattison Denise , Rush Nicole , Gillespie Sherrie , Danford Cynthia A. , Siedlecki Sandra L. 
Published: October 2024

ABSTRACT
This case report presents a 34-year-old Middle Eastern woman with atypical symptoms of Type II Necrotizing Soft Tissue Infection (NSTI). Due to the difficulty in diagnosing Type II NSTI, the patient experienced protracted illness. Once diagnosed, the patient underwent multiple surgical debridement procedures requiring antibiotic and pain management therapy before being successfully discharged home. Initial diagnosis of Type II NSTI is challenging to the provider due to vague symptoms and late occurrence of cutaneous changes. When cutaneous lesions are identified, rapid surgical evaluation is imperative to minimize morbidity and mortality. This paper emphasizes the complexity of diagnosing Type II NSTI and the need for a comprehensive history and frequent physical examinations.
Prediction of preoperative lymph-vascular space invasion and survival outcomes of cervical squamous cell carcinoma by utilizing 18F-FDG PET/CT imaging at early stage
Authors: Li Jiatong , Cui Nan , Wang Yanmei , Li Wei , Jiang Zhiyun , Liu Wei , Guo Chenxu , Wang Kezheng 
Published: October 2024

Objective
To establish nomograms for predicting preoperative lymph-vascular space invasion (LVSI) and survival outcomes of cervical squamous cell carcinoma (CSCC) based on PET/CT radiomics.

Methods
One hundred and twenty-three patients with CSCC and LVSI status were enrolled retrospectively. Independent predictors of LVSI were identified through clinicopathological factors and PET/CT metabolic parameters. We extracted 1316 features from PET and CT volume of interest, respectively. Additionally, four models (PET-RS: radiomic signature of PET only; CT-RS: radiomic signature of CT only; PET/CT-RS + clinical data; PET/CT-RS: radiomic signature of PET and CT) were established to predict LVSI status. Calculation of radiomics scores of PET/CT was executed for assessment of the survival outcomes, followed by development of nomograms with radiomics (NR) or without radiomics (NWR).

Results
One hundred and twenty-three patients with pathologically confirmed CSCC had been categorized into two sets (training and testing sets). It was found that only maximum standardized uptake value (SUVmax) and squamous cell carcinoma antigen were independent predictors of LVSI. Meanwhile, the PET/CT-RS + clinical data outperformed the other three models in the training set [area under the curve (AUC): 0.91 vs. 0.861 vs. 0.81 vs. 0.814] and the testing set (AUC: 0.885 vs. 0.857 vs. 0.783 vs. 0.798). Additionally, SUVmax and LVSI had been demonstrated to be independent prognostic indicators for progression-free survival and overall survival. Decision curve analysis and calibration curve indicated that NRs were superior to NWRs. The survival outcomes were assessed.

Conclusion
PET/CT-based radiomic signature nomogram enables a new method for preoperative prediction of LVSI and survival prognosis for patients with CSCC.
Rare presentation of huge ectopic ureterocele in an adult female: a case report
Authors: Jawaid Muhammad D. , Anwaar Adeel , Athar Hamna , Wahaj Zainab , Ali Masab , Saeed Humza , Ahmad Muhammad Husnain 
Published: October 2024

Introduction and importance:
Ectopic ureteroceles are primarily found in children, often detected incidentally during antenatal ultrasonography or due to urinary tract infection (UTI) symptoms. However, they are rare in adults, with limited published cases.

Case presentation:
This report details a case of a 24-year-old woman who experienced recurrent UTIs and sudden urinary retention, ultimately needing manual compression to urinate due to poor urine flow. Intravenous urography revealed a large right ectopic ureterocele that protruded through the urethra during urination. Cystoscopy confirmed extensive right-sided ureteroceles affecting the bladder and causing her urinary difficulties.

Clinical discussion:
Although ectopic ureteroceles in adults can present with a range of symptoms, including obstruction and recurrent infections, the management approach is often individualized based on the clinical presentation and imaging findings. In this case, endoscopic incision was chosen for its minimally invasive nature, leading to full recovery without complications. Despite the risks of recurrence and potential scarring, the patient showed no recurrence at follow-up and remains symptom-free.

Conclusion:
This case underscores the rarity of symptomatic giant ectopic ureteroceles in adult females and highlights the importance of considering this condition in women with recurrent UTIs.
Physical Therapy Management of Congenital Muscular Torticollis: A 2024 Evidence-Based Clinical Practice Guideline From the American Physical Therapy Association Academy of Pediatric Physical Therapy
Authors: Sargent Barbara , Coulter Colleen , Cannoy Jill , Kaplan Sandra L. 
Published: October 2024

Background:
Congenital muscular torticollis (CMT) is a postural condition evident shortly after birth. The 2013 CMT Clinical Practice Guideline (2013 CMT CPG) set standards for the identification, referral, and physical therapy management of infants with CMT, and its implementation resulted in improved clinical outcomes. It was updated in 2018 to reflect current evidence and 7 resources were developed to support implementation. Purpose: This 2024 CMT CPG is intended as a reference document to guide physical therapists, families, health care professionals, educators, and researchers to improve clinical outcomes and health services for children with CMT, as well as to inform the need for continued research. Results/Conclusions: The 2024 CMT CPG addresses: education for prevention, screening, examination and evaluation including recommended outcome measures, consultation with and referral to other health care providers, classification and prognosis, first-choice and evidence-informed supplemental interventions, discontinuation from direct intervention, reassessment and discharge, implementation and compliance recommendations, and research recommendations.
Development and Implementation of an Evidenced-Based Practice (EBP) Educational Program for a Multidisciplinary Rehabilitation Department
Authors: Hedgecock James B. , Muir Nancy B. , Mahnken Heather , Silveira Lori J. , Ziegler Katelyn , Judd Dana L. 
Published: October 2024

Objective:
Describe the development and implementation of an evidence-based practice (EBP) training program for occupational and physical therapists in a large pediatric hospital.

Context:
EBP is valued, but a known knowledge-to-practice gap between academic training and clinical practice limits routine use. This gap was addressed through an academic-clinical partnership to develop an EBP training program.

Results:
Sixty-one therapists completed the program. Therapists demonstrated improved EBP skills, knowledge, and confidence following training and a positive trend in change score for clinical outcomes and decision-making scores was noted.

Conclusion:
Academic-clinical partnerships have a unique and valuable role to support professional EBP knowledge and skill development. Stakeholder support and engagement supported program development, execution, and meaningful outcomes.

Impact Statement:
The knowledge-to-practice gap for EBP is a challenge to regular EBP use. The described program addressed this challenge and improved therapists’ knowledge, skills, and confidence. It provides a model for professional development.