bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Mediasi Citra Merek dan Persepsi Risiko pada Hubungan antara Electronic Word of Mouth (E-WOM) dan Minat Beli (Studi pada Konsumen Kosmetik E-Commerce di Solo Raya)
Authors: Eriza Zahra Noor 
Published: October 2017

AbstrakElectronic word of mouth (E-WOM) banyak dimanfaatkan konsumen untuk menggali informasi mengenai suatu produk. Informasi yang diperoleh dari berbagai sumber di internet akan mempengaruhi persepsi konsumen terhadap citra merek, risiko dan mendorong minat beli konsumen. Penelitian ini menganalisis peran mediasi citra merek dan persepsi risiko pada hubungan E-WOM dan minat beli. Sampel penelitian ini terdiri dari 149 konsumen di Solo Raya yang telah melakukan pembelian kosmetik melalui e-commerce. Hasil penelitian menunjukkan bahwa E-WOM berpengaruh positif terhadap minat beli dan citra merek. Pengujian regresi mediasi menyimpulkan bahwa citra merek memediasi secara parsial hubungan E-WOM dan minat beli. Hasil tersebut mengartikan bahwa aktivitas membaca ulasan produk di internet akan memberikan informasi mengenai manfaat dan keunggulan produk sehingga konsumen akan merasa yakin bahwa mereka memilih produk yang tepat dan mendorong minat beli konsumen. Sedangkan E-WOM berpengaruh negatif terhadap persepsi risiko namun tidak memediasi hubungan E-WOM dan minat beli. Kata kunci : E-WOM, Minat Beli, Citra Merek, Persepsi Risiko.
Kualitas Pelayanan Publik dalam Perizinan di Pelayanan Terpadu Satu Pintu (PTSP) Kantor Badan Penanaman Modal dan Pelayanan Perizinan Terpadu (BPMP2T) Kabupaten Boyolali
Authors: Enggarani Nuria Siswi 
Published: October 2017

Penelitian ini bersifat penelitian hukum normatif-empiris dengan menggunakan pendekatan perundang-undangan (statute approach) dan pendekatan konseptual (conceptual approach). yang merupakan perpaduan antara penelitian hukum normatif (kepustakaan) dan penelitian hukum empiris (lapangan). Penelitian ini bertujuan untuk menguraikan konsep perizinan di Pelayanan Terpadu Satu Pintu (PTSP) di kantor BPMP2T Kabupaten Boyolali, menjelaskan maklumat dan standar pelayanan di kantor BPMP2T dan perbandingannya sesuai UU No. 25 tahun 2009 tentang pelayanan publik dan juga menjelaskan mekanisme / alur pelayanan dan pengaduan masyarakat sebagai tolok ukur kualitas pelayanan publik di kantor BPMP2T Boyolali. Penelitian ini dimaksudkan guna melakukan pengukuran kualitas pelayanan publik dalam perizinan PTSP di Kantor BPMP2T Boyolali yang dapat diukur berdasarkan indikator: tangible, reability, responsiveness, assurance, dan emphaty. Dalam mencapai tujuan, digunakan metode wawancara dengan indeepht interview dan kuesioner untuk pelaksana pelayanan publik di kantor BPMP2T Boyolali dan dengan metode kepustakaan
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENERIMAAN PAJAK (Studi Empirik di Kantor Pelayanan Pajak Pratama Surakarta)
Authors: Cahyono Yuli Tri 
Published: October 2017

This research is aimed to examine and analyze the influence of tax evasion, tax compliance by tax payer, self assessment system, awareness of tax payer, the comprehension on tax laws, and perceptions of service quality towards the level of tax income. The total sample of this research were 95 individual tax payers. The technique to collect sample in this research is convenience sampling. The data analysis method is multiple linear regression. The results of this research shows that the variable of perceptions of service quality give the influence towards the tax income, meanwhile the variable of tax evasion, tax compliance by tax payer, self assessment system, awareness of tax payer, the comprehension on tax laws are not influence towards the tax income. Keywords: tax evasion, self assessment system, perceptions of service quality, the level of tax income
التأشير والتباعد بين القدماء والمحدثين مقاربة تداولية
Authors: Dizayi Delxosh J. H 
Published: October 2017

أراد هذا البحث الموسوم بـ ( التأشير والتباعد بين القدماء والمحدثين - مقاربة تداولية) أن يعالج محوراً أساسياً من التداولية ؛ليبحث عن جذوره وتأصيل مفاهيمه في الإرث اللغوي العربي بقراءته قراءة تداولية ثانية ؛لإبراز معالم التداولية في توجهات القدماء وطروحاتهم اللغوية عموماً ، وذلك بتعمق البحث في التعابير الإشارية - المتفرعة إلى (الإشاريات الشخصية و المكانية والزمانية والخطابية والاجتماعية) المُعالجة في مباحث مخصصة في هذا البحث- وكيفيات استعمالها ودواعي تناولها واقتضاءاتها الاجتماعية بإجراء مقاربة تداولية بين المفاهيم التأشيرية بالوقوف عند الكفاية التفسيرية والوصفية للإشاريات ،ثم تطبيقها في التحليلات اللغوية القديمة ؛لكشف خصوبة البحث اللساني العربي بمثل هذه المستجدات اللغوية وثراء معالجات القدماء بهذه الرؤى والتفسيرات المعرفية والخطابية،فتولد هذا البحث بثوبه الجديد وبإجراء متابعة عميقة ودقيقة لجهود القدماء في حقل النحو والبلاغة والتفسير الذي فاض بمفاهيم تلك الإشاريات وأنماطها الخطابية المحدِّدة للأبعاد الشخصية والزمانية والمكانية والخطابية والاجتماعية المستعملة في النماذج العربية الفصيحة أو النصوص القرآنية التي أبانها العلماء بالتفسير والتحليل.
Etnobotánica y sistemas de extracción para compuestos fenolicos, actividad antioxidante y toxicidad de plantas de paramos y bosques nublados del norte peruano
Authors: Torres-Guevara Fidel A. , Ganoza-Yupanqui Mayar L. 
Published: October 2017

Objetivo. Realizar una investigación etnobotánica con enfoque participativo, para identificar especies originarias de los paramos y bosques de neblina de los andes del norte peruano, promisorias desde el punto de vista nutricional y terapeútico, mediante cinco sistemas de extracción que den precisión al análisis de la presencia de las sustancias bioactivas responsables de sus propiedades. Materiales y Metodos. Estudio etnobotanico. Se realizó por consenso de asambleas y participación activa de las organizaciones comunales en la determinación de objetivos, programación, ejecucion de acciones, encuestas, viajes de colecta y eleccion de las especies de interes de las comunidades. Se prepararon extractos al 10% P/V de 19 especies de interes, usando cinco sistemas: tres hidroalcoholicos (etanol a 96° GL, etanol a 70° GL y etanol a 45° GL) y dos acuosos (infusion y decoccion) a los cuales se aplicaron los metodos Folin Ciocalteu, para evaluar compuestos fenolicos; DPPH para evaluar la actividad antioxidante, y bioensayos de toxicidad mediante exposicion de Artemia salina, a fin de determinar la concentracion letal media (CL50). Resultados. Tres especies del paramo y dos del bosque nublado, de las 19 estudiadas, muestran valores significativos de compuestos fenolicos, actividad antioxidante y no poseen toxicidad: Myrcianthes myrsinoides, Bejaria resinosa, Acaena ovalifolia, Cuphea ciliata, Muehlenbeckia hastulata. Conclusión. El enfoque de investigación participativa en la etnobotánica optimizo el registro de los conocimientos tradicionales y permitio la identificación de cinco especies, con sus respectivos métodos de extracción, promisorias para futuras investigaciones preclínicas de efectos específicos, acordes con el uso tradicional.
Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis
Authors: Filkova Maria , Carvalho João , Norton Sam , Scott David , Mant Tim , Molokhia Mariam , Cope Andrew , Galloway James 
Published: October 2017

Objective.Polypharmacy (PP), the prescribing of multiple drugs for an individual, is rising in prevalence. PP associates with an increased risk of adverse drug reactions (ADR) and hospital admissions. We investigated the relationship between PP, characteristics of rheumatoid arthritis (RA), and the risk of unplanned hospital admissions.Methods.Patients from a hospital RA cohort were retrospectively analyzed. Information was collected from electronic medical records. Cox proportional hazards were used to compare hospitalization risk according to levels of PP. Admissions were adjudicated to determine whether an ADR was implicated.Results.The study included 1101 patients; the mean number of all medications was 5. PP correlated with increasing age, disease duration, disease activity, and disability. At least 1 unplanned admission occurred for 16% of patients. Patients taking ≥ 10 medications had an adjusted HR for hospitalization of 3.1 (95% CI 2.1–4.5), compared to those taking 0–5 medications. Corticosteroid use associated with a doubling in adjusted risk of admission of 1.7 (95% CI 1.2–2.4). The most common reason for hospitalization was infection (28%). While in half of all admissions an ADR was a possible contributing factor, only 2% of admissions were found to directly result from an ADR.Conclusion.PP is common in RA and is a prognostic marker associated with increased risk of acute hospitalizations. Our data suggest that PP may be an indicator of comorbidity burden rather than a contributing cause of a drug-related toxicity. PP should be monitored to minimize inappropriate combination of prescribed medications. PP may be a useful predictor of clinical outcomes in epidemiologic studies.
Aplicación de la metodología de aprendizaje basado en problemas a la docencia de Veterinaria Legal
Authors: Henríquez Hernández Luis Alberto , Pérez Luzardo Octavio , Domínguez Boada Luis , Almeida González Maira , Zumbado Peña Manuel 
Published: October 2017

El aprendizaje basado en problemas (ABP) es una estrategia de enseñanza centrada en el alumno, que adquirirá conceptos complejos llevando a la práctica conocimientos previos sobre una disciplina concreta. En el campo de la Veterinaria Legal, el peritaje forense forma parte central de los conocimientos que el alumno debe adquirir. Desde el curso 2010/2011, los alumnos de Veterinaria de la Universidad de Las Palmas de Gran Canaria, realizan un peritaje forense mediante ABP. Los alumnos, divididos en grupos de 6-8 individuos, trabajan un problema desde dos puntos de vista diferentes: el del demandado y el del demandante. Durante el proceso, los alumnos son tutorizados y las dos posturas se enfrentan en el aula para defender su postura, donde el profesor ejerce de juez, y el resto de compañeros de jurado. La actividad es valorada con 1-3 puntos. Durante 5 cursos, un total de 275 alumnos han realizado la actividad, con el 50,91% de los alumnos obteniendo la máxima calificación. Los alumnos se muestran satisfechos con la actividad. Concluimos por tanto que la metodología de ABP en Veterinaria Legal es bien aceptada por los alumnos, que perciben que les aporta una importante cantidad de conocimientos de forma autónoma. El trabajo en grupo es estimulante y favorece la comunicación entre los alumnos.
OVAM: Museo de Anatomía Veterinaria Virtual: Resumen de lo hecho hasta ahora y futuros modelos para sostenibilidad y mantenimiento
Authors: Gaitskell-Phillips Gemma , Short Nick , López-Albors Octavio , Latorre Rafael 
Published: October 2017

<p>A día de hoy OVAM (<a href="http://www.onlineveterinaryanatomy.net">www.onlineveterinaryanatomy.net</a>) es el proyecto interfacultativo más grande de anatomía veterinaria. El museo es repositorio online de acceso libre para el uso de materiales de anatomía veterinaria de alta calidad y valor pedagógico de múltiples grupos de trabajo, disponible al publico, estudiantes, investigadores, docentes y profesionales veterinarios.</p><div data-canvas-width="274.088">Para asegurar una máxima difusión se están diseñando nuevas formas de desarrollo y su integración en el currículo. Además, recientemente se ha introducido un proceso de evaluación por pares, lo que asegura una mayor calidad del contenido. En este artículo se describen las novedades del proyecto y las estrategias de desarrollo hasta la fecha. Asegurar la financiación es un gran reto, en parte porque los usuarios no esperan tener que pagar por el contenido ya que existen recursos gratis en internet. Posibles fuentes de financiación incluirían acuerdos de subscripción o licencias, asociaciones con grupos relevantes, mecenazgo, apoyo comercial y la participación de estudiantes de Master tras identificación de temas adecuados de investigación. Hasta ahora el proyecto OVAM ha contado con una financiación incipiente y el apoyo de los socios fundadores. Sin embargo, como todos los proyectos sin ánimo de lucro de cara al futuro deberá contar con un sistema financiero continuado que garantice su supervivencia y actualización futuras.</div>
Palladium-103 plaque radiation therapy for ciliary body melanoma through a functioning glaucoma filtering bleb
Authors: Pathan Arif H.K. , Barash Alexander , Tena Lawrence B. , Finger Paul T. 
Published: October 2017

Purpose: To provide a clinical description of the long-term outcome of a 103Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb. Methods: A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a 103Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. At plaque insertion, amniotic membrane grafts were used to cover the plaque and protect the filtering site. Results: The tumor was successfully treated without clinical evidence of harm to the filtering bleb, with resultant stable intraocular pressure. However, the patient developed blebitis 1.5 years later. Though it resolved with topical antibiotic therapy, the bleb became less succulent. Two years postoperatively, she developed a spontaneous hyphema that resolved after one injection of transscleral bevacizumab 1.25 mg. Her tumor continually regressed in thickness. Without additional glaucoma surgery, her intraocular pressure remained well-controlled on topical medications for 6 years. Conclusions: Ciliary body melanoma with minimal extrascleral extension beneath a functioning filtering bleb can be treated using radioactive plaque therapy. In this case, we were able to achieve both tumor regression and glaucoma control by covering the plaque with an amniotic membrane graft.
A Modern Radiologic Treatment for Pelvic Congestion Syndrome Associated with Chronic Pelvic Pain and Menstrual Abnormalities
Authors: Kanter Jessica R. , Looney Christopher B. , Lue John , Gavrilova-Jordan Larisa P. 
Published: October 2017

Introduction With greater than one-tenth of outpatient gynecology visits attributed to chronic pelvic pain, research into etiology and management of the spectra of chronic pain disorders is very important. One such etiology, pelvic congestion syndrome (PCS), is a disease in which pelvic varicosities are present as a result of dysfunctional venous valves, retrograde blood flow, venous hypertension, and dilation. The presence of these varicosities, which exist in up to 10% of women between 18 and 76 years of age, can be detected by various imaging techniques including ultrasound, contrasted computed tomography, and magnetic resonance imaging. Various treatment methodologies have been described for the management of this chronic pain disorder, including medical, endovascular, and surgical therapies. With advancements in imaging, and the opportunity for endovascular intervention via interventional radiology, minimally invasive left ovarian vein embolization is at the forefront of therapeutic efforts for this nefarious condition. Methods We present here our clinical experience of 9 patients with PCS who underwent left ovarian vein embolization using a standardized protocol. Results Subjective pain relief was noted in 8 of 9 patients; 7 of the 9 patients reported complete resolution of pain at the 4-week follow-up, and associated symptoms similarly resolved. Conclusions Any thorough evaluation of a patient with chronic pelvic pain should include an evaluation for PCS when the diagnosis is not immediately available. Increased physician awareness of PCS is imperative for the future. With these astounding results, we recommend an excellent option for treatment of patients with left ovarian vein embolization.
Tocilizumab is a promising treatment option for therapy resistant juvenile localized scleroderma patients
Authors: Foeldvari Ivan , Anton Jordi , Friswell Mark , Bica Blanca , de Inocencio Jaime , Aquilani Angela , Helmus Nicola 
Published: October 2017

Introduction Juvenile localized scleroderma (jlSc) usually responds well to treatment with methotrexate or mycophenolate. In case of nonresponse or partial response, tocilizumab (TOC) appears to be a promising option. Methods Participants of the Pediatric Rheumatology Email Board were asked to report patients with jlSc treated with TOC. Results Six centers responded and reported 11 patients. The mean age at disease onset was 5.5 years. Disease duration at time of the initiation of TOC was 4.5 years. A total of 5 patients had linear subtype, 2 Parry Romberg syndrome, and 1 morphea en coup de sabre. Three had a generalized subtype, 2 a mixed subtype, and 1 a limited subtype/morphea. Before starting TOC, 10 of 11 patients received methotrexate, 7/11 combination methotrexate and mycophenolate, 1 abatacept, and 1 antitumor necrosis factor therapy. The indications for starting TOC were: (i) an increase in the score of the Localized Scleroderma Activity Index (mLoSSI) in 9 patients; and (ii) evidence of increased extra-cutaneous activity in 2 patients. The mean duration of TOC therapy was 14.75 months. Three of 11 patients received TOC as monotherapy, and 8/11 as combination therapy. Therapy success was reflected by a decreased mLoSSI in 9/11 patients, no new lesion occurrence, and – with Parry Romberg syndrome subtype – no increase in facial atrophy. In 8/8 patients, both the physicians’ and patients’ global assessment of disease activity decreased. In 3/3 patients, the number of active joints decreased. The mean modified Rodnan skin score decreased from 8.7 to 5.6. Conclusions In this small cohort of patients, TOC seems to be a promising rescue medication.
Efficacy of Idelalisib as Bridge to Allogeneic Stem Cell Transplant in Relapsed Follicular Lymphoma: A Case Report
Authors: Marangon Miriam , Pellegrini Cinzia , Argnani Lisa , Zinzani Pier Luigi 
Published: October 2017

Purpose A large number of new therapeutic agents have been studied for patients with relapsed/refractory follicular lymphoma (FL). Among new therapies, idelalisib, a novel PI3K inhibitor, shows promising results in the management of this disease. Case report We describe the case of a 39-year-old patient with a diagnosis of grade 3a FL and a Follicular Lymphoma International Prognostic Index score of 2, who underwent several lines of therapy (including autologous stem cell transplant) with transient responses or no response at all. The patient was subsequently treated with 5 courses of idelalisib monotherapy, achieving a partial response. No relevant toxicities occurred. The patient underwent allogeneic stem cell transplant (allo-SCT) from an unrelated donor and obtained a complete response, which was confirmed after 3, 6, 9, and 12 months, and is still ongoing. Conclusions As previously reported, the achievement of a good response is predictive for a better outcome after allo-SCT: idelalisib represents an effective treatment option for patients with relapsed/refractory FL, which can also be adopted as a bridge to allo-SCT.
Dicentric Translocation (9;12) in Acute Lymphoblastic Leukemia: A Chromosomal Abnormality with an Excellent Prognosis?
Authors: Illade Laura , Fioravantti Victoria , Andion Maitane , Hernandez-Marques Carmen , Madero Luis , Lassaletta Alvaro 
Published: October 2017

Purpose Recurrent chromosomal abnormalities present in the leukemic cells of pediatric patients with acute lymphoblastic leukemia (ALL) often allow us to classify patients according to their prognosis, in order to establish further treatment. The dicentric translocation (9;12) consists of the rearrangement of the short arms of chromosomes 9 and 12 generating a dicentric chromosome (9;12). Patients with this alteration present a very good response to treatment and an excellent prognosis. Methods We present the case of an adolescent with ALL in which the dicentric translocation (9;12) was observed in the karyotype of the blasts at diagnosis. Results and conclusion Given the excellent results of our patient and most of the series published to date, an international study is necessary to determine the true prognostic significance of this molecular alteration.
Uncommon Somatic Mutations in Metastatic NUT Midline Carcinoma
Authors: Cavalieri Stefano , Stathis Anastasios , Fabbri Alessandra , Sonzogni Angelica , Perrone Federica , Tamborini Elena , Pelosi Giuseppe , de Braud Filippo , Platania Marco 
Published: October 2017

Introduction NUT midline carcinoma (NMC) is a rare and aggressive epithelial cancer arising from median organs. It is driven by chromosomal translocation t(15;19) involving the rearrangement of NUT (nuclear protein in testis) and BRD4 (bromodomain 4) genes leading to fusion oncoprotein BRD4-NUT. Case presentation We report the case of a woman who was previously treated with induction chemotherapy, surgery, radiotherapy and adjuvant trastuzumab for HER-2 positive invasive ductal carcinoma of the breast. After 6 months of follow-up a lung nodule appeared. A biopsy showed an adenocarcinoma fetal type/lung blastoma, so a left inferior lobectomy was performed: NMC harboring BRD4-NUT rearrangement was diagnosed. After 9 months of follow-up, bone and soft tissue metastases occurred, so the patient was given radiotherapy. Next-generation sequencing technology identified somatic mutations in deleted in colorectal cancer (DCC), mixed lineage leukemia protein 3 (MLL3), and splicing factor 3B subunit 1 (SF3B1) genes in NMC cells from both primitive cancer and metastases. The patient was treated with the experimental BRD4 inhibitor for 10 months, until the disease progressed to the lung and bone. After spinal cord compression, the patient was offered palliative radiotherapy to bone and eventually died aged 39 years. Conclusions To the best of our knowledge, our case is the first DCC, MLL3, and SF3B1 mutated NUT midline carcinoma reported in the literature. If these mutations were confirmed to play a role in this neoplasm, clinical trials analyzing targeted therapies should be considered, eg. colorectal cancer-like chemotherapies for DCC mutations, hypomethylating agents for MLL3 mutations or SF3B1 inhibitors in case of specific somatic mutations.
Original Flow Chart for the Management of Hydroureteronephrosis Caused by Pessary Placement
Authors: Balzarro Matteo , Rubilotta Emanuele , Porcaro Antonio B. , Trabacchin Nicolò , D'Amico Antonio , Cerruto Maria Angela , Artibani Walter 
Published: October 2017

Hydroureteronephrosis due to pessary is a dangerous complication that can become critical if urosepsis is present. We propose a flow chart to manage the condition. Introduction The use of a pessary to treat a pelvic organ prolapse (POP) is a valid non-invasive option. Severe complications are usually associated with neglected, oversized, or misplaced pessaries. Major complications include fistulas, bowel or bladder erosion, and hydroureteronephrosis (HUN). Materials and Methods We reviewed the literature and our experience in the management of HUN in the last decade, as a consequence of pessary placement. Results We used flow charts to take an accurate medical history of each patient. Blood and urine analyses were taken at admission to assess the potential presence of sepsis, renal failure, and urinary tract infection. Physical examination included vaginal examination. In cases of pessary presence with a concomitant increase of serum creatinine value, a possible ureteral obstruction is suspected. In order to assess the presence of HUN and its underlying causes, a computed tomography (CT) scan should be performed to assess the mechanism of urinary tract obstruction. However, in case of renal insufficiency, abdominal ultrasonography (US) could be sufficient. If HUN is detected in a patient with no signs of urosepsis, we suggest a conservative management by the removal of the pessary and catheter placement. When urosepsis is suspected, it is mandatory to administer antibiotic therapy and evaluate the HUN drainage by nephrostomy. Conclusions There is no uniform management of women with HUN and a concomitant pessary. For this reason, and based on the literature and our experience, we propose an original management flowchart.