bluuebunny/crossref_metadata_2025_split huggingface dataset:
Based on the local image of the visual involute gear pitch measurement method
Authors: Zhi Shan , Ji Changli , Wang Zihao , Du Po 
Published: October 2024

Abstract

This paper aims to rapidly measure the small and medium module spur gear pitch in industry and solve the complex problem of visual measurement. It proposes an algorithm for a single-gear pitch based on the statistical information of the tooth profile image edge’s transition zone. Firstly, the local image of the involute gear was processed; Then, based on the geometric characteristics of the involute tooth profile edge, a pixel point parameter database has been established, the transition zone's pixel information is inversely mapped to the base circle to calculate the initial phase angle of the tooth profile edge involute. Finally, the gear pitch is calculated by using the initial phase angles of two adjacent tooth profiles with the same name. In addition, through theoretical analysis and simulation calculation, the sine curve model of the initial phase Angle error of the tooth profile caused by the eccentricity of the base circle positioning is obtained. The results show that: 1.When the eccentricity e ≤ 40 µm, when the positioning error Δψj ≤ 1°, it can meet the measurement requirements of 5-level precision gear; 2. Measuring the pitch of the same 5th-grade precision gear, the difference between the two pitches measured by the visual gear measuring instrument and the Coordinate Measuring Machine is 0.4 µm and 0.2 µm, respectively; 3. The maximum single-pitch deviation of the visual gear measuring instrument and the M&M3525 gear measuring center is on the same pitch. The difference between the two is 0.7 µm, and the total deviation of the pitch accumulation is 3.3 µm. It indicates that this gear pitch visual measurement method can meet the rapid measurement requirements of the 5th-grade precision spur gear pitch.
Research on Mathematical Model of Rolling Force for Asymmetrical Rolling of Cu/Al Clad Plate
Authors: Chen Suwen , Ding Wenjie , Zhang Zhiquan , Sun Jianliang , Gu Dapeng 
Published: October 2024

Abstract

Based on the principal stress method, the mathematical model of rolling force for asymmetrical rolling of Cu/Al clad sheet is established.The lengths of different deformation intervals are solved based on the geometric relationship and the deformation characteristics of clad shee. The stress of differential element in different deformation zones is analyzed, combined with the equilibrium differential equation, geometric relationship of deformation zones, boundary conditions and yield criterion, and the rolling pressure in different deformation zones is solved. According to the calculation results, the influence law of process parameters on rolling force, neutral point position and cross-shear zone length is analyzed, which provides a theoretical basis for further research on rolling process.
How cultural and creative tourism product design affects the psychological generation of cultural confidence：evidence from the Three Gorges Museum in China
Authors: Xia Jinjun , Li Yashi , He Yuanheng 
Published: October 2024

Abstract

Cultural confidence is a critical social psychological phenomenon with respect to efforts to promote cultural development, social harmony, and personal spiritual growth. Advances in economic development and improved living standards lead to increased demand for cultural and creative tourism products that offer humanistic experiences and spiritual fulfillment. An important task is thus to explore how the cultural creative tourism products design (CCTPD), which serve as crucial media for cultural dissemination, influence the psychological generation of cultural confidence. The CCTPD items was classified into five dimensions based on the strategic experiential model (SEMs): SENSE, FEEL, ACT, THINK, and RELATE. This study investigated the Cultural and Creative Experience Pavilion at the Three Gorges Museum in Chongqing, China, using 321 responses collected via a field survey. Structural equation modelling (SEM) was employed to investigate the mechanism underlying the psychological generation of cultural confidence and the specific impacts of CCTPD on this mechanism. The results indicated that the psychological generation of cultural confidence is characterized by a sequential progression from cultural cognition to cultural identity and, ultimately, to cultural confidence. As a cultural carrier, CCTPD significantly influences each stage of this process and has the strongest impacts on cultural cognition. Furthermore, different dimensions of CCTPD affect the stages of the process by which cultural confidence is generated in different ways. Specifically, sense experience, act experience, and think experience significantly affect cultural cognition; think experience and relate experience significantly affect cultural identity; and sense experience, relate experience, and feel experience significantly influence cultural confidence. The findings of this research provide insight for both cultural psychology and design studies, and can serve as a reference for policy-makers to promote cultural confidence and designers in implement targeted practices.
Aging and semantic transparency effects during Chinese reading: Evidence from eye movements
Authors: Cao Xuran , Du Yaxin , Wang Jingxin 
Published: October 2024

Abstract

Background
Semantic transparency of radicals is the degree to which constituent radicals are semantically related to the meaning of a whole character. Semantic transparency is important in compound words processing. Previous studies mostly used priming paradigm to examine semantic transparency effects on young adults. However, considering that vision typically changes with age, it is important to establish whether semantic transparency effects are equivalent across adulthood.
Methods
Young (18–25 years) and older (65 + years) adults were recorded while reading sentences with transparent and opaque target words. In Experiment 1, these target words were present throughout reading. In contrast, Experiment 2 used a gaze-contingent paradigm.
Results
Both groups showed greater difficulty processing opaque words than transparent words. In Experiment 1, however, there were no interactions, confirming that semantic transparency effects are similar for both age groups. In Experiment 2, semantic transparency effects were greater for older adults. Therefore, opaque words are more difficult to process than transparent words.
Conclusions
Semantic transparency effects are not significantly moderated by age during normal reading, although the interaction effects in Experiment 2 suggests that older adults rely on character-based reading strategies to compensate for decreased parafoveal processing abilities, as lexical representation is especially important for transparent words processing.
Pyrophosphate-Free Glycolysis in Clostridium thermocellum Increases Both Thermodynamic Driving Force and Ethanol Titers
Authors: Sharma Bishal Dev , Hon Shuen , Thusoo Eashant , Stevenson David M. , Amador-Noguez Daniel , Guss Adam M. , Lynd Lee R. , Olson Daniel G. 
Published: October 2024

Abstract

Background
Clostridium thermocellum is a promising candidate for production of cellulosic biofuels, however its final product titer is too low for commercial application, and this may be due to thermodynamic limitations in glycolysis. Previous studies in this organism have revealed a metabolic bottleneck at the phosphofructokinase (PFK) reaction in glycolysis. In the wild type organism, this reaction uses pyrophosphate (PPi) as an energy cofactor, which is thermodynamically less favorable compared reactions that use ATP as a cofactor. Previously we showed that replacing the PPi-linked PFK reaction with an ATP-linked reaction increased the thermodynamic driving force of glycolysis, but only had a local effect on intracellular metabolite concentrations, and did not affect final ethanol titer.
Results
In this study, we substituted PPi-pfk with ATP-pfk, deleted the other PPi-requiring glycolytic gene pyruvate:phosphate dikinase (ppdk), and expressed a soluble pyrophosphatase (PPase) and pyruvate kinase (pyk) genes to engineer PPi-free glycolysis in C. thermocellum. We demonstrated a decrease in the reversibility of the PFK reaction, higher levels of lower glycolysis metabolites, and an increase in ethanol titer by an average of 38% (from 15.1 g/L to 21.0 g/L) by using PPi-free glycolysis.
Conclusions
By engineering PPi-free glycolysis in C. thermocellum, we achieved an increase in ethanol production. These results demonstrate that optimizing the thermodynamic landscape through metabolic engineering can enhance product titers. While further increases in ethanol titers are necessary for commercial application, this work represents a significant step toward engineering glycolysis in C. thermocellum to increase ethanol titers.
O USO DOS BLOQUEADORES NEUROMUSCULARES E AS AÇÕES DE ENFERMAGEM
Authors: Bárbara de Castro Oliveira Barbosa  , Flávia dos Santos Lugão de Souza  , Roberta Mendes Von Randow  
Published: October 2024

O presente estudo tem como objetivo descrever as características dos bloqueadores, elucidar os principais diagnósticos de enfermagem e possíveis planos de cuidados para o paciente em uso de bloqueadores neuromusculares. Foram coletados artigos de 2013 a 2023 na Biblioteca Virtual em Saúde nos meses de maio a junho de 2023 tendo como resultado 14 artigos inerentes ao assunto que se encontraram pertencentes a linha do tempo escolhida. Os bloqueadores neuromusculares são medicamentos usados comumente na rotina de cuidados da Unidade de Terapia Intensiva, sendo utilizados em procedimentos como a intubação orotraqueal e na manutenção de sedação dos pacientes. Assim, concluiu-se que os Bloqueadores Neuromusculares são medicamentos que se usados com cautela e parcimônia se mostram de grande ajuda no tanto no âmbito emergencial, como numa intubação orotraqueal como também podem ser utilizados para manutenção da sedação de pacientes.
Positive eWOM and Consumers with a Fear of Missing Out
Authors: Putri Ni Luh Debby Maharani Eka , Sulhaini Sulhaini , Saufi Akhmad 
Published: October 2024

The study aims at examing the effect of positive electronic word of mouth (eWOM) and consumers with Fear Of Missing Out (FOMO) of local skincare products. This research is quantitative in nature. the population are Indonesians who have shopped for local skincare products through s-commerce applications. the number of samples were 150. The data analysis is Structural Equation Modeling (SEM) approach, especially Partial Least Square (PLS) method. The results showed that positive eWOM had no significant effect on impulse buying, while price discount showed the opposite. The study also found that FOMO strengthens the effect of eWOM on impulse buying, suggesting that if the fear of missing out is high, positive eWOM prompts consumers to buy products impulsively.
Homocysteine Blood Levels and Mandatory Folic Acid Fortification in Serbia
Authors: Vasiljevic Zorana , Zlatic Natasa , Rajic Dubravka , Mitrovic Predrag , Viduljevic Mihajlo , Matic Dragan , Asanin Milika , Stankovic Sanja 
Published: October 2024

Introduction:
The current study aims to investigate the blood Hcy levels in patients with CAD and
hypertension in Serbia, a country with a high incidence and mortality of both diseases

Methods:
The level of Hcy in the Serbian population was assessed in 123 patients with chronic coronary
artery disease (CAD) and hypertension. There were 53 patients with chronic CAD and 70 patients with hypertension
(HTA), but without CAD.

Results:
The Hcy levels were high in both groups of patients (the mean Hcy level of 16.0 ± 7.0 μmol/L) without
a statistical difference between the patients in the CAD (14.9 ± 7.3 μmol/L) and hypertension (16.7 ± 6.7
μmol/L) groups. Hypercholesterolemia was found in 81% of the patients with CAD and 92.0% of the patients
with HTA, as a common concern across both clinical conditions. It was also found that not a single conventional
risk factor (diabetes, hypertension, the smoking status, the family history of CAD, and hyperlipidemia) may
individually influence Hcy levels. By contrast, the low levels of vitamin B12 may be related to the high levels
of Hcy.

Conclusion:
Given the fact that it is known that various factors interact and influence Hcy levels and associated
cardiovascular risks, specific dietary habits, lifestyle and the other Serbia-specific possible factors were
done.
Dihydroartemisinin Modulates Prostate Cancer Progression by Regulating Multiple Genes via the Transcription Factor NR2F2
Authors: Shao Yong , Chan Yunhui , Zhang Chuan , Zhao Rong , Zu Yuxin 
Published: October 2024

Objective:
This study aimed to investigate the effect of dihydroartemisinin (DHA) on
DU145 cells and the role of NR2F2 (COUP-TFII) and its potential target genes in this process.

Methods:
GSE122625 was used to identify differentially expressed genes (DEGs) between the
DHA-treated and control groups. Protein-protein interaction (PPI) network analysis was performed
to identify hub genes, and the ChEA3 database was used to identify potential transcription
factors. qRT-PCR and Western blot were used to validate the expression of genes of interest
and functional assays were performed to evaluate the effect of DHA on DU145 and PC-3 cells.
To solidify the regulatory relationship of NR2F2 with EFNB2, EBF1, ETS1, and VEGFA, a
Chromatin Immunoprecipitation (ChIP) experiment was performed.

Results:
We identified 85 DEGs in DU145 cells treated with DHA, and PPI network analysis
identified NR2F2 as a hub gene and potential transcription factor. The regulatory network of
NR2F2 and its potential target genes (EFNB2, EBF1, ETS1, and VEGFA) was constructed, and
the expression of these genes was upregulated in DHA-treated cells compared to control cells.
Functional assays showed that DHA treatment inhibited epithelial-mesenchymal transition, reduced
inflammation, and promoted apoptosis in DU145 and PC-3 cells. Furthermore, NR2F2
knockdown receded the DHA-induced upregulation of target genes and functional changes of
DU145 and PC-3 cells. The outcomes of ChIP unequivocally pointed to a positive regulatory
role of NR2F2 in these gene expressions.

Conclusion:
Our study suggests that DHA treatment affects the functions of DU145 and PC-3
cells by regulating the expression of NR2F2 and its potential target genes, and NR2F2 may serve
as a potential therapeutic target for prostate cancer.

result:
We identified 85 DEGs in DU145 cells treated with DHA, and PPI network analysis identified NR2F2 as a hub gene and potential transcription factor. The regulatory network of NR2F2 and its potential target genes (EFNB2, EBF1, ETS1, and VEGFA) was constructed, and the expression of these genes was found to be upregulated in DHA-treated cells compared to control cells. Functional assays showed that DHA treatment inhibited epithelial-mesenchymal transition, reduced inflammation, and promoted apoptosis in DU145 and PC-3 cells. Furthermore, NR2F2 knockdown receded the DHA-induced upregulation of target genes and functional changes of DU145 and PC-3 cells. ChIP’s outcomes unequivocally pointed to a positive regulatory role of NR2F2 in these gene expressions.
Identifying Prostaglandin D2 Synthase in Urine: A Potential Biomarker for Bladder Cancer
Authors: Tan Lia-Beng , Tyan Yu-Chang , Hsu Jen-Yi , Hsen Kun-Hung , Liao Pao-Chi , Guo How-Ran 
Published: October 2024

Introduction:
Proteins present in body fluids harbor the potential to act as markers for
both diagnosing diseases and exploring their underlying mechanisms. As urine can be easily obtained
non-invasively, analyzing its proteins is an ideal approach to identifying biomarkers for
bladder cancer. This study aimed to identify proteins in urine that could serve as biomarkers for
bladder cancer.

Method:
Urine samples were collected from patients with primary transitional cell carcinoma of
the bladder and their age and sex-matched healthy individuals. The protein pellet underwent resolubilization
and trypsin digestion to facilitate analysis using reverse phase nano-high performance
liquid chromatography/electrospray ionization tandem mass spectrometry.

Result:
In samples obtained from 16 patients and 8 controls, 3192 peptides were identified, corresponding
to 934 unique proteins, of which 60 were identified with higher confidence levels.
Among them, Transferrin and Prostaglandin D2 Synthase (PTGDS) were found as potential markers
of bladder cancer. In particular, the absence of PTGDS has a specificity of 100% and a sensitivity
of 81%.

Conclusion:
This study, which used proteomic approaches, identified PTGDS in urine as a potential
biomarker of bladder cancer.
Design, Synthesis, Biological Evaluation, Molecular Docking, and Molecular Dynamics Simulation Studies of Fmoc-L-Lysine Carboxamides as Promising Cytotoxic Agents
Authors: Parepalli Mahalakshmi C.S. , Galla Rajitha 
Published: October 2024

Background:
Despite advancements in treatment modalities, the search for new cytotoxic
agents remains vital in the fight against cancer. This ongoing effort aims to introduce novel molecules
that serve as potent cytotoxic agents while minimizing adverse effects.

Objective:
The objective of the study is to design, synthesize, and evaluate Fmoc-L-Lysine Carboxamides
for cytotoxic activities.

Methods:
The title compounds 4a-l were synthesized by esterification followed by reduction of
Fmoc-Lys (Boc)-OH to alcohol, then coupled with various aryl/alkyl/alicyclic carboxylic acids. These
compounds were then analysed using 13C NMR, 1H NMR, FT-IR, and Mass spectroscopic techniques
and evaluated for cytotoxic activity by MTT assay, apoptosis induction, cell cycle analysis,
EGFR-TK inhibition activity, molecular docking, and molecular dynamics simulation studies.

Results:
The results obtained by MTT assay indicated that compounds 4f and 4i demonstrated significant
cytotoxicity against A549 and SKOV3 cell lines, with IC50 values of 2.75 and 1.91μM compared
to doxorubicin. Further, the analysis of the Cell cycle and apoptosis proposed that 4f arrested
the cell cycle in the G0/G1 phase, whereas 4i arrested the cell cycle in the G2/M phase and triggered
apoptosis in cancer cells. Notably, compound 4i demonstrated the highest inhibition of EGFR with
IC50, 0.189μM, and acted as its potential inhibitor. Molecular docking and dynamics simulation studies
further confirmed the stability of 4i in the active site of EGFR.

Conclusion:
Overall, these results suggested that the synthesized derivatives offer a promising approach
for the advancement of new and effective cancer therapies.
Cross-River Transmission Corridor Scheme Evaluation Based on Hierarchical Analysis Method
Authors: Cai Chenlin , Tang Bo , Qi Daokun , Li Xianxin , Zhang Linfeng , Zhang Longbin 
Published: October 2024

Background:
In order to solve the problems of single influencing factors and inconsistency
of subjective experience of multiple experts under different working conditions in the
evaluation of existing cross-river transmission corridor schemes, a cross-river transmission corridor
scheme evaluation method based on hierarchical analysis has been proposed in this work.

Method:
Firstly, six evaluation indices, including planning and important facility areas, environmentally
sensitive points, geological conditions, hydrological conditions, safety and economy,
have been established to construct a system for assessing the impact factors of cross-river transmission
corridors. Then, the hierarchical analysis method has been combined with the improved
grey correlation analysis to synthesize the weight judgement values of multiple experts, construct
a unified scoring system for the weights of qualitative and quantitative indexes, effectively improve
the stability of the indexes' weights, and realize the scientific assessment of the cross-river
transmission channel scheme. Finally, the engineering scheme of a cross-river transmission channel
has been evaluated.

Results:
Through practical engineering analysis, the selected cross-river transmission channel using
this method has been found to be consistent with the actual project.

Conclusion:
The results have shown that the method could effectively achieve the evaluation of
various cross-river transmission channel schemes by comprehensively considering a variety of
factors in the selection of cross-river corridors for transmission lines and effectively protecting the
empirical roles of different experts.
Optimizing Federated Reinforcement Learning Algorithm for Data Management of Distributed Energy Storage Network
Authors: Li Yuan , Li YuanCheng 
Published: October 2024

Background:
The development of energy storage networks has facilitated the rapid
expansion of new energy-based power systems. However, the emergence of large-scale energy
storage devices has also led to a significant increase in energy data volumes. Federated learning
provides a solution by allowing energy data owners to train AI models without sharing local energy
data, which is particularly advantageous for handling heterogeneous data.

Objective:
This paper explores the application of federated learning in managing energy data within
distributed energy storage networks. Specifically, we leverage deep reinforcement learning algorithms
to optimize the selection of device subsets, aiming to mitigate data bias caused by nonidentically
and independently distributed (non-IID) data while enhancing convergence rates.

Method:
To achieve our objectives, we employ deep reinforcement learning to dynamically select
the optimal subset of devices in the federated learning process. Additionally, we introduce a reputation
replay array mechanism to address the issue of free-rider users and ensure fair modeling
without payment penalties. We analyze energy data characteristics within distributed energy storage
networks and simulate unstructured short data fragments using datasets such as 20 Newsgroups
and AG News.

Results:
Our experiments show that our proposed model outperforms FedAvg and TiFL on the 20
Newsgroups and AG News datasets, especially under non-iid conditions. Our model significantly
reduces communication rounds by up to 47% and 39%, respectively. It also maintains high accuracy
and resilience against dishonest nodes, ensuring the quality of the training model.

Conclusion:
Our research concludes that combining federated learning with deep reinforcement
learning not only solves the problems of data management and privacy protection in distributed
energy storage networks, but also promotes the sustainable development of new energy systems.