bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline
Authors: Wedzicha Jadwiga A. , Calverley Peter M.A. , Albert Richard K. , Anzueto Antonio , Criner Gerard J. , Hurst John R. , Miravitlles Marc , Papi Alberto , Rabe Klaus F. , Rigau David , Sliwinski Pawel , Tonia Thomy , Vestbo Jørgen , Wilson Kevin C. , Krishnan Jerry A. 
Published: September 2017

This document provides clinical recommendations for the prevention of chronic obstructive pulmonary disease (COPD) exacerbations. It represents a collaborative effort between the European Respiratory Society and the American Thoracic Society.Comprehensive evidence syntheses were performed to summarise all available evidence relevant to the Task Force's questions. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach and the results were summarised in evidence profiles. The evidence syntheses were discussed and recommendations formulated by a multidisciplinary Task Force of COPD experts.After considering the balance of desirable (benefits) and undesirable consequences (burden in the form of adverse effects and cost), quality of evidence, feasibility, and acceptability of various interventions, the Task Force made recommendations for mucolytic, long-acting muscarinic antagonist, phosphodiesterase-4 inhibitor (roflumilast) and macrolide therapy, as well as a conditional recommendation against fluoroquinolone therapy. All of the recommendations were conditional, except for a strong recommendation for the use of a long-acting antimuscarinic agentversusa long-acting β2-adrenergic, indicating that there was uncertainty about the balance of desirable and undesirable consequences of the intervention, and that well-informed patients may make different choices regarding whether to have or not have the specific intervention.The guideline summarises the evidence and provides recommendations for pharmacological therapy for the prevention of COPD exacerbations.
The mediatization of politics in the hybrid media system: The case of Italian political journalism
Authors: Splendore Sergio , Rega Rossella 
Published: September 2017

Abstract
Despite the major changes that have occurred in the ecology of media, this article considers mediatization to be still a concept valuable for grasping and interpreting relations among political communication actors. This article analyses the use of Twitter by politicians as evidenced by journalists’ accounts (and practices). In particular, it focuses on journalistic uses of Twitter in the context of political current affairs. This article investigates how and to what degree the use of social media has changed journalists’ practices in gathering political news. Moreover, it analyses how journalists describe politicians’ use of Twitter and how they reflexively conceive whether adjustments by those politicians to the media logic exist. To this end, the studies present results from 25 semi-structured interviews with Italian journalists occupying prominent roles within the Italian news organizations most important in terms of newspaper circulations and unique visitors to their websites. The research proves that mediatization is still an important framework within which to interpret practices in the new media environment.
The world as seen by a Prime Minister: Italian PM Matteo Renzi on his spin doctor’s Instagram page
Authors: Buscemi Francesco 
Published: September 2017

Abstract
This article analyses the representation of the Italian Prime Minister Matteo Renzi on the Instagram page nomfup, which is managed by Renzi’s spin doctor, Filippo Sensi. nomfup’s photos are frequently published in the Italian media, and thus contribute to the construction of Renzi’s public image. The article draws on Bourdieu’s perspectives on cultural production, on the cultural studies link between media and ideology, and on Barthes’ idea that photography relates to the past. Methodologically, it analyses nomfup’s photos through social semiotics, focusing on images depicting Renzi from the back and in black and white. The results show that first, when Renzi is represented from his back, the viewer sees the world as a Prime Minister does. Second, the images representing Renzi in black and white refer to the 1950s and 1960s, to the old Catholic party Democrazia Cristiana and to an idealized Italy still pre-modern and extraneous to Berlusconi’s excesses and scandals.
Political communication in an age of visual connectivity: Exploring Instagram practices among Swedish politicians
Authors: Ekman Mattias , Widholm Andreas 
Published: September 2017

Abstract
This article explores the specific features of Instagram as a platform for visual political communication. Drawing on theories of mediatization and celebrity politics, it analyses how various forms of symbolic connectivity are expressed and performed by sixteen leading politicians in Sweden, and moreover how their social media use relates to news media. The study leans on a content analysis (n=800) and results show that journalism still holds a strong symbolic value, even when politicians are in charge of the political discourse. In addition, it reveals how the platform logic of Instagram contributes to the formation of digital lifestyle politics, where symbolic connections between politicians and a variety of actors are staged through new mediatized relations. Visual political communication does inherit a democratic and interactive potential. However, according to the analysed data, most politicians avoid public interaction. Instead, they are preoccupied with the branding of their public persona.
Facebook and local newspapers’ effect on local politicians’ popularity
Authors: Elvestad Eiri , Johannessen Marius Rohde 
Published: September 2017

Abstract
While there has been much research on how national politicians’ popularity is related to their participation in both traditional and social media, less research has been undertaken in order to understand the role of media for local politicians. In this article, we discuss how local politicians’ appearance in local newspapers, on Facebook and how their network of Facebook ‘friends’ can be explanation factors of their popularity in Norwegian local elections. The sample consists of 605 local politicians from two municipalities who were on the list of party candidates in these two municipalities in the 2015 election. Our findings show that the local newspaper is more important for the local politicians’ popularity than Facebook, but the politicians’ use of Facebook and numbers of Facebook ‘friends’ show a significant positive correlation with the numbers of preference votes the politicians receive. The effect of Facebook ‘friends’ on local politicians’ popularity shows the importance of connections, which again stresses the need for a greater awareness of the consequences of local politicians’ social networks both offline and online in local political processes.
Image, self-presentation and political communication in the age of interconnection: An alternative understanding of the mediatization of politics
Authors: Archetti Cristina 
Published: September 2017

Abstract
The way politicians ‘look’ is taken to be one of the essential aspects of the ‘mediatization’ and ‘professionalization’ of politics. Yet there is very little research about the role of image and self-presentation in political communication. This article presents the results of a study that aims to fill this gap by mapping where and how image fits within broader processes of identity and meaning construction in contemporary politics. On the basis of 51 interviews, it compares the role of personal image in the everyday political practices of both British and Italian local politicians and members of the European Parliament. The analysis develops an alternative conceptual framework to make sense of the role of image in twenty-first century politics, showing that the alleged deleterious effects of a ‘cult of appearances’ on democracy reflects more the narrowness of academic enquiry and the legacy of outdated linear models of politics-media relationships than the much more variegated and networked reality of contemporary politics.
Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn
Authors: Sharifi-Rad J. , Salehi B. , Schnitzler P. , Ayatollahi S. A. , Kobarfard F. , Fathi M. , Eisazadeh M. , Sharifi-Rad M. 
Published: September 2017

In recent years, with increased the prevalence of viral infections and having no specific for their treatment and also the continuous appearance of resistant viral strains, the finding of novel antiviral agents is necessary. In this study, monoterpenes of thymol, carvacrol, p-cymene and essential oils from Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn. were screened for their inhibitory effect against herpes simplex virus type 1 (HSV-1) in vitro on Vero cell line CCL-81-ATCC using a plaque reduction assay. The antiviral activity of three monoterpenes (thymol, carvacrol and p-cymene) and three essential oils were evaluated by cytotoxicity assay, direct plaque test. In addition, the modes of antiviral action of these compounds were investigated during the viral infection cycle. Results showed that the inhibitory concentrations (IC50) were determined at 0.002%, 0.037%, >0.1%, 0.035%, 0.018% and 0.001% for thymol, carvacrol, p-cymene, S. arvensis oil, L. royleana oil and P. vulgaris oil, respectively. A manifestly dose-dependent virucidal activity against HSV-1 could be exhibited for compounds tested. In order to determine the mode of the inhibitory effect, compounds were added at different stages during the viral infection cycle. At maximum noncytotoxic concentrations of the compounds, plaque formation was significantly reduced by more than 80% when HSV-1 was preincubated with p-cymene. However, no inhibitory effect could be observed when the compounds were added to the cells prior to infection with HSV-1 or after the adsorption period. Conclusion: These results indicate that compounds affected HSV-1 mostly before adsorption and might interact with the viral envelope. Thymol exhibited a high selectivity index and seems to be a promising candidate for topical therapeutic application as antiviral agent for treatment of herpetic infections.
New insights into the expression profile of MicroRNA-34c and P53 in infertile men spermatozoa and testicular tissue
Authors: Rahbar S. , Novin M. G. , Alizadeh E. , Shahnazi V. , Pashaei-Asl F. , AsrBadr Y. A. , Farzadi L. , Ebrahimie E. , Pashaiasl M. 
Published: September 2017

Spermatogenesis is proliferation and differentiation processes of stem spermatogonia into mature spermatozoa controlled by the genes responsible for transcription and post transcription levels. MicroRNAs (miRNA) are the key factors during gene expression in RNA silencing and post-transcriptional regulation. They play main roles in regulation of early and late spermatogenesis, and reproduction. In this study, we investigate the role of miRNAs in infertile males.The patients were assigned to five groups based on semen analysis (n=55), including normozoospermic (N), moderate oligoasthenoteratozoospermic (MOAT), severe oligoasthenoteratozoospermic (SOAT), obstructive azoospermia (OA) and non-obstructive azoospermia (NOA). Quantitative RT-PCR was recruited to study the expression of miR-34c and tumor suppressor p53 gene. In addition, malondialdehyde (MDA) and DNA fragmentation was measured. Network analysis was performed using Pathway Studio web tool (Elsevier). Our results revealed statistically significant increased expression of miR-34c in moderate oligoasthenoteratozoospermic, non-obstructive azoospermia and an increased expression of p53 in MOAT, SOAT and NOA males. Also, the percentage of DNA fragmentation and oxidative stress was significantly higher in infertile groups (MOAT and SOAT) than other groups. These findings provide a novel molecular mechanism of gene regulation during cell-cycle and apoptosis in sperm, which gives a new regulatory insight into male infertility in terms of molecular diagnosis.
Investigation of the irisin, preptin and adropin levels in the blood serum of Alburnus tarichi
Authors: Caf F. , Algul S. , Koyun M. 
Published: September 2017

Irisin, preptin and adropin are three newly discovered peptides that play critical roles in regulating energy homeostasis in various vertebrates.The purposes of this study were to measure the serum concentrations of preptin, adropin and irisin in the Alburnus tarichi and to investigate the relationship of these peptides to the weight, gender and length of this the fish, which will provide useful information for future biotechnology purposes aimed at improvements in aquaculture production. This study used 12 adult A. tarichi (6 female and 6 male) obtained from Van Lake (Van, Turkey). The serum irisin, preptin and adropin levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit to determine correlations between the levels of these three hormones and fish body weight and length. No statistically significant correlations were detected between the serum irisin, adropin and preptin levels and A. tarichi body weight (p = 0.921, r = -0.031; p = 0.08, r = 0.519; p = 0.461, r = -0.235, respectively) or length (p = 0.901, r = -0.040; p = 0.105, r = 0.490; p = 0.236, r = -0.369, respectively).Thus, serum levels of these hormones are independent of fish gender, body weight and length.
Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population
Authors: Attar R. , Yilmaz S. G. , í‡akmakoğlu B. , Duman S. , Yildirim G. , Görmüş U. , ć°sbir T. 
Published: September 2017

The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52).There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x2=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.
Atypical bacterial etiology of acute respiratory infections and clinical characterizations among Iranian children
Authors: Halaji M. , Hashempour T. , Pouladfar G. R. , Ghasabi F. , Khashei R. 
Published: September 2017

Acute respiratory infections (ARIs) in children younger than 5 years of age are one of the leading causes of morbidity and mortality, particularly in developing countries. Mycoplasma pneumoniae and Chlamydophila pneumoniae are prevalent causative agents of ARIs, worldwide. We sought M. pneumoniae and C. pneumoniae in respiratory samples from Iranian children with ARIs. From November 2014 to April 2015, respiratory samples of 150 children aged 1 month to 15 years old were screened for presence of M. pneumoniae and C. pneumoniae. Polymerase chain reaction (PCR) and culture methods were used to detect these bacteria in respiratory samples in the form of throat swabs and nasopharyngeal aspirates. A questionnaire containing demographic and clinical information has been filled up for all participants in this study. Our obtained data showed that out of 150 tested samples, 7 (4.7%) were PCR positive for M. pneumoniae and only one (0.7%) positive sample for C. pneumoniae was detected. However, none of the tested samples was detected M. pneumoniae using the bacterial culture method. All patients with ARIs due to M. pneumoniae showed up with sore throat and flu like symptoms. According to our data, PCR method is more sensitive than culture for detection of M. pneumoniae. With regards to our results, it appears that M. pneumoniae and especially C. pneumoniae were infrequent causative agents in our studied population.
On the regularity of solutions to the plastoelasticity problem
Authors: Cellina Arrigo 
Published: September 2017

Abstract
We prove the local regularity of solutions to the problem of minimizing

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Restriction on the re-export of medicinal products and the supervision of compliance with it by public administration bodies
Authors: Peráček T. , Vojtech F. , Srebalová M. , Pekár B. , Mikušová-Meričková B. , Horvat M. 
Published: September 2017

Abstract
After years of mainly expert discussions (not only in the Slovak legal environment), the concept of and legislation on re-export offer a sort of solution provided for in the Act no. 306/2016 Coll. Said act amends the key legislation in this field, namely the Act no. 362/2011 Coll. on Medicinal Products and Medical Devices and on the amendment of certain acts, as amended (hereinafter referred to as the “Act on Medicinal Products”) and the Act no. 363/2011 Coll. on the Scope and Conditions of Payments for Medicinal Products, Medical Devices and Dietetic Foods from Public Health Insurance and on the amendment of certain acts, as amended (hereinafter referred to as the “Act on Payments”). The topic of the paper belongs in the area of medicinal products and pharmaceutical services, it offers, however, significant overlaps in the area of the constitutional, administrative and European law and is aimed at multidisciplinary research into the issue of the reverse export (re-export) of medicinal products. Besides these laws, also the Constitution of the Slovak Republic (“SR”) and the sources of the European Law have to be taken into account in relation to the subject in question. The main aim of legislation in this area of law was restriction on the re-export of selected products and protection of patients from adverse impacts of such business activity. The aim of the paper is the authors’ effort to analyse the issue of the re-export of medicinal products within the context of the adopted Act no. 306/2016 Coll., whose legislative solution is inevitable for the protection of life and health of the population of the Slovak Republic.
GNU Radio Based Testbed (GRaTe-BED) for Evaluating the Communication Link of Unmanned Aerial Systems
Authors: Szabó András 
Published: September 2017

Abstract
UAS (Unmanned Aerial Systems) are commonly used in 3D (dull, dirty and dangerous) missions, because these are not endangering the operators life, while reduce maintenance costs and increase maneuvering capabilities. Despite of these advantages we should consider the possible vulnerabilities of this technology as well. Unmanned vehicles can be controlled via direct communication link, or they can work in a preprogrammed mode. Usually the preprogrammed mode is based on radio navigation systems, so we can draw a conclusion that both depend on the RF environment. In this paper I analyze a possibility to effectively evaluate the communication link of an UAS. Developers have to consider several key factors (type of operation, endurance, payload type and size, propulsion, communication link, etc.) during the development process. They are also responsible that the final product meets the predefined requirements. On the other side commercial UAS owners should have a possibility to compare and evaluate the UAS before the acquisition. Finally, operators and frequency management entities need tools to diagnose the possible sources of interference regarding the unmanned vehicles. To understand the consequences of interference in the RF spectrum we have to be able to measure the quality of the communication link in different usage scenarios. In my research I evaluate the usage of SDRs (Software Defined Radios) in RF Test and Evaluation processes. After analyzing the possibilities for a flexible testbed, I demonstrate the usability with some measurements in the GNU Radio signal processing framework.
Der Beitrag der Gebäudeautomation zum energieeffizienten
Gebäudebetrieb
Authors: Felsmann Clemens 
Published: September 2017

Zusammenfassung
Die energetischen Aufwendungen, die im Zusammenhang mit
der Nutzung von Gebäuden entstehen, lassen sich mit
Hilfe energieeffizienter Gebäudesysteme minimieren.
Die Gebäudeautomation ist unverzichtbarer Bestandteil dieser Systeme und
sichert über die Steuerung, Regelung und das
Management der gebäudetechnischen Anlagen die bedarfsgerechte
Energieversorgung. Im Rahmen
öffentlich-rechtlicher Nachweise zur Einhaltung von
Mindestanforderungen oder für optimierte Investitionsentscheidungen
sollte die Effektivität von Gebäudeautomationssystemen und deren
Beitrag zur Gesamtenergieeffizienz von Gebäuden quantifiziert werden
können. Im folgenden Beitrag werden geeignete
Berechnungsansätze beschrieben.
Automatically enabled analytics in buildings and smart homes
Authors: Dibowski Henrik 
Published: September 2017

Abstract
Building analytics are critical
for detecting faults, initiating appropriate maintenance
actions and ensuring a faultless and energy-efficient
operation. Their setup however is
cost-expensive, as it requires
considerable effort of qualified engineers. Besides
that, analytics are typically
equipment-centric, but unaware of
other parts of a building and how things are
interrelated. To improve that, this
article presents a knowledge-based approach that is
based on a rich ontology model for Building Automation System
(BAS). Complemented by a specification of the
analytics, an automatic setup of analytics can be
enabled. Furthermore, a fault
propagation approach is presented that can determine how faults propagate in
BAS. It can interrelate and combine the analytics and
create an overall picture and improved comprehension of BAS and their
behavior.
Vorausschau in frühen Planungsphasen der Gebäudeautomation
Authors: Kabitzsch Klaus , Mai Tuan Linh , Lehmann Matthias , Wollschlaeger Bastian , Engelien Heike , Eichenberg Elke 
Published: September 2017

Zusammenfassung
Die Planung der
Gebäudeautomation (GA) wird durch zahlreiche Brüche in fachlicher
(Gewerketrennung) und zeitlicher Hinsicht (Planungsphasen)
behindert. Eine integrale Herangehensweise kann nur
durch Stärkung der frühen Planungsphasen erreicht
werden. Dafür wird eine wissensbasierte
Methoden- und Toolunterstützung
vorgestellt, die nur wenig Mehraufwand
kostet.
Modellbasierte Inbetriebnahme und online-Konfiguration von Gebäudeautomationssystemen
Authors: Scholz André , Becker Uwe , Fay Alexander 
Published: September 2017

Zusammenfassung
Ein Gebäudeautomationssystem (GA-System) ist durch eine Vielzahl
von automatisierten Funktionen geprägt. Die Planung und Auslegung
eines GA-Systems ist daher ein aufwändiger und
fehlerträchtiger Vorgang. Um eine frühzeitige Funktionsanalyse
und Fehlererkennung zu gewährleisten, wurde ein Ansatz für
eine effiziente Erstellung eines funktionalen Modells für die GA
entwickelt, mit dem ein GA-System simuliert, ausgelegt und
konfiguriert werden kann. Dieser Ansatz wurde nun weiterentwickelt, um
die Parameter aus dem Modell für die Inbetriebnahme, die
online-Diagnose und die online-Anpassung des GA-Systems zu nutzen.