bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance spectroscopy as a diagnostic model for assessment of liver steatosis in metabolic dysfunction-associated steatotic liver disease in non-diabetic patients
Authors: El-Nakeep Sarah , Foda Enas , Sheha Aliaa S. , Abdelazeem Sara Mohamed , Mohamed Ghada Abdelrahman 
Published: September 2024

Abstract
Background
Metabolic dysfunction-associated steatotic liver (MASLD) disease is the commonest hepatic cause of liver fibrosis and cirrhosis after the introduction of the direct acting antivirals and eradication of hepatitis C. MASLD is usually associated with metabolic syndrome and elevated inflammatory markers. Magnetic resonance spectroscopy (MRS) offers a non-invasive diagnostic, alternative to liver biopsy. This is a case–control diagnostic-accuracy study conducted on 40 patients in the Hepato-gastroenterology Unit in the Internal Medicine Department, Ain Shams University Hospitals, to study the role of MRI spectroscopy as a new diagnostic model for assessment of liver steatosis in non-diabetic MASLD patients compared to the standard ultrasound and clinical criteria. MASLD was diagnosed by a combination of a validated ultrasound hepatic steatosis score grading system and hepatic steatosis index using clinical and laboratory parameters. MRS was performed in all patients and fat peak, water peak, and fat fraction % were measured, and diagnostic accuracy of different MRS is compared to the US scoring and different laboratory and clinical parameters. To our knowledge this is the first study conducted on MRS in our region and Egypt.

Results
This study revealed no statistically significant difference between the two groups regarding HbA1C, creatinine, while there was highly statistically significant difference regarding fasting blood sugar, 2 h post-prandial glucose level, urine albumin, and low-density lipoprotein levels. Hepatic steatosis score grading by abdominal ultrasound on the 20 controls showed no fatty changes with grade 0 (50%), and on the 20 MASLD patients showed that 2 cases were grade 1 steatosis (5%), 9 cases were grade 2 steatosis (22.5%), and 9 cases were grade 3 steatosis (22.5%). The diagnostic accuracy of predicting hepatic steatosis using different MRS parameters: fat peak, water peak, and fat fraction had area under the curve of 99.9%, 88.6%, and 100%, respectively. The sensitivity and specificity of fat fraction in detecting hepatic steatosis were 100%. The sensitivity and specificity of the fat peak in detecting hepatic steatosis were 100% and 95%, respectively. Moreover, the sensitivity and specificity of the water peak in detecting the hepatic steatosis were 88.6% and 85%, respectively. There is a statistically significant correlation between the three MRS parameters and the abdominal ultrasound hepatic steatosis score grades.

Conclusion
MRS parameters: fat fraction, fat peak, and water peak, have high diagnostic accuracy for predicting the liver steatosis. Moreover, MRS has the added advantage of being a non-invasive and a tool with low radiation risk. MRS also shows the metabolic changes in the liver and could be an eligible outcome in therapeutic clinical trials.
In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method
Authors: Abd El‑Fattah Marwa A. , El-Demerdash Asmaa O. , Eassa Heba A. , Mohammed Kamilia H. A. , Khalil Israa A. , Esmaeil Asmaa H. , Abdel Aziz Shimaa E. , Amin Omnia M. 
Published: September 2024

Abstract
Background
Wound healing is a natural but complex process that can be delayed by infection. Rosuvastatin calcium (RVS) is an anti-hyperlipidemic that was recently reported to have a wound healing capability. The study aimed to investigate the impact of combining RVS with Levofloxacin (LV) on wound healing. A physically crosslinked polyvinyl alcohol (PVA) film loaded with RVS and LV was formulated as wound dressing. Formulation optimization was carried out using Box–Behnken design. The effect of independent variables (PVA and propylene glycol concentrations and the number of freeze–thaw cycles) on tensile strength (TS), elongation to break (%EB) and in vitro drugs’ release was studied. For simultaneous RVS and LV quantification in the formulations and pure form, three spectrophotometric methods: derivative of ratio spectrophotometry, first derivative and mean centering, were developed. Also, their greenness was evaluated by the Analytical Eco-Scale and the Green Analytical Procedure Index. Then, the wound healing effect of the optimized wound dressing was evaluated in rat models.

Results
The optimized dressing had sufficient mechanical strength (9.45 ± 0.67 MPa), adequate flexibility (112.6 ± 3.8% EB) and suitable drug release (52.3 ± 1.4% for LV and 38.99 ± 1.6% for RVS after 12 h). The proposed methods were validated following ICH guidelines, and greenness assessment suggested their very low environmental effect. The wound healing evaluation showed a higher wound contraction percentage when RVS was combined to LV. A histopathological study confirmed marked improvement in animals treated with combined formula with lowest inflammatory infiltration and optimum epithelialization, compared to other groups.

Conclusion
Study findings suggest that combined LV-RVS dressing would be a beneficial platform with potentiated wound healing capacity.

Graphic abstract
Patient satisfaction with endoscopic ear surgery technique: a comparative study with the postauricular incision microscopic technique
Authors: Metwaly Osama , Salah Mohamed , Ali Abdelrahman 
Published: September 2024

Abstract
Background
Endoscopic ear surgery has numerous benefits, such as the capacity to obtain high-resolution pictures and visualize normally inaccessible locations such as the retrotympanum, sinus tympani, and facial recess. These areas are generally difficult to access with traditional microscopic techniques. Endoscopic ear surgery reduces operating time when performed by skilled surgeons, without the need for a postauricular incision wound.
An essential aspect to consider when evaluating the effects of any procedure on individual satisfaction is the assessment of health-associated quality of life. It is a tool used for subjective assessment, which is regarded as a reliable measure of the satisfaction perceived—whether physically or mentally—resulting from a certain procedure.
The goal of this study was to identify the benefits of middle ear surgery when done endoscopically compared to postauricular microscopic techniques in middle ear surgery. This was achieved by evaluating and comparing the level of satisfaction among patients who underwent either microscopic or endoscopic ear surgery.

Methods
The Chronic Ear Surgery Survey (CESS), a 13-point Likert scale survey designed specifically for assessing outcomes of surgery for chronic middle ear disease, was implemented to measure patient satisfaction. The survey comprises three subscales. We performed a retrospective study at the Otorhinolaryngology Department, Cairo University, Egypt. The study encompassed individuals who underwent surgery on the middle ear between March 2018 and September 2021.
The patients were scheduled into two categories according to the technique of surgery (whether endoscopic or microscopic) in order to assess postoperative satisfaction using the Chronic Ear Surgery Survey (CESS).

Results
Our research findings demonstrated a statistically significant difference between the two categories in terms of the overall scores and all subscale scores of the Chronic Ear Surgery Survey (CESS), with patients who had middle ear surgery endoscopically (EES) showing better outcomes.

Conclusions
Identifying the elements that are strongly associated with subjective outcomes can assist surgeons in identifying patients who are more likely to have poorer satisfaction. This knowledge can be valuable in preoperative counseling. Endoscopic ear surgery (EES) seems to have a higher level of cosmetic acceptability, especially in terms of enhancing the socially related aspects of a patient's pleasure. This work thus supports the ongoing integration of endoscope utilization in otological surgical procedures.
Usability of an at-home tablet-based cognitive test in older adults with and without cognitive impairment
Authors: Bayer Thomas A. , Liu Yanchen , Vishnepolskiy Igor , Baez Day , Sanders Lisbeth , Williams Rebecca , Sanders Jeff , Serpico Anthony , Gravenstein Stefan 
Published: September 2024

Abstract
Background
Mobile device-based cognitive screening has the potential to overcome the limitations in diagnostic precision and efficiency that characterize conventional pen and paper cognitive screening. Several mobile device-based cognitive testing platforms have demonstrated usability, but the usability of take-home mobile device-based cognitive screening in typical adult primary care patients requires further investigation.

Methods
This study set out to test the usability of a prototype mobile device-based cognitive screening test in older adult primary care patients across a range of cognitive performance. Participants completed the St. Louis University Mental Status Examination (SLUMS) and then used a study-supplied mobile device application at home for 5 days. The application presented 7 modules lasting approximately 15 min. Participants completed the System Usability Scale (SUS) after using the application.

Results
A total of 51 individuals participated, with a median (IQR) age of 81 (74–85) years. Cognitive impairment (SLUMS score < 27) was present in 30 (59%) of participants. The mean (95% Confidence Interval [CI]) SUS score was 76 (71–81), which indicates good usability. Usability scores were similar across ranges of cognitive impairment. A Lower SLUMS score predicted early withdrawal from the study with an area under the receiver operating characteristic curve (95% CI) of 0.78 (0.58–0.97).

Conclusion
Take-home mobile device-based cognitive testing is a usable strategy for many older adult primary care patients. Depending on patient preferences and abilities, it could be part of a flexible cognitive testing and follow-up strategy that includes mobile device-based testing in healthcare settings and pen-and-paper cognitive testing.
Personal independence payments among people who access mental health services: results from a novel data linkage
Authors: Stevelink Sharon A. M. , Bakolis Ioannis , Dorrington Sarah , Downs Johnny , Leal Ray , Madan Ira , Phillips Ava , Geiger Ben , Hotopf Matthew , Fear Nicola T. 
Published: September 2024

BackgroundPersonal independence payment (PIP) is a benefit that covers additional daily living costs people may incur from a long-term health condition or disability. Little is known about PIP receipt and associated factors among people who access mental health services, and trends over time. Individual-level data linking healthcare records with administrative records on benefits receipt have been non-existent in the UK.AimsTo explore how PIP receipt varies over time, including PIP type, and its association with sociodemographic and diagnostic patient characteristics among people who access mental health services.MethodA data-set was established by linking electronic mental health records from the South London and Maudsley NHS Foundation Trust with administrative records from the Department for Work and Pensions.ResultsOf 143 714 working-age patients, 37 120 (25.8%) had received PIP between 2013 and 2019, with PIP receipt steadily increasing over time. Two in three patients (63.2%) had received both the daily living and mobility component. PIP receipt increased with age. Those in more deprived areas were more likely to receive PIP. The likelihood of PIP receipt varied by ethnicity. Patients diagnosed with a severe mental illness had 1.48 odds (95% CI 1.42–1.53) of having received PIP, compared with those with a different psychiatric diagnosis.ConclusionsOne in four people who accessed mental health services had received PIP, with higher levels seen among those most likely in need, as indicated by a severe mental illness diagnosis. Future research using this data-set could explore the average duration of PIP receipt in people who access mental health services, and re-assessment patterns by psychiatric diagnosis.
Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking
Authors: el Azhar Yasmine , Schulthess Pascal , van Oostrom Marek J. , Weterings Sonja D. C. , Meijer Wilke H. M. , Tsuchida-Straeten Nobuko , Thomas Wouter M. , Bauer Marianne , Sonnen Katharina F. 
Published: September 2024

ABSTRACT
The intricate dynamics of Hes expression across diverse cell types in the developing vertebrate embryonic tail have remained elusive. To address this, we have developed an endogenously tagged Hes1-Achilles mouse line, enabling precise quantification of dynamics at the single-cell resolution across various tissues. Our findings reveal striking disparities in Hes1 dynamics between presomitic mesoderm (PSM) and preneural tube (pre-NT) cells. While pre-NT cells display variable, low-amplitude oscillations, PSM cells exhibit synchronized, high-amplitude oscillations. Upon the induction of differentiation, the oscillation amplitude increases in pre-NT cells. Additionally, our study of Notch inhibition on Hes1 oscillations unveils distinct responses in PSM and pre-NT cells, corresponding to differential Notch ligand expression dynamics. These findings suggest the involvement of separate mechanisms driving Hes1 oscillations. Thus, Hes1 demonstrates dynamic behaviour across adjacent tissues of the embryonic tail, yet the varying oscillation parameters imply differences in the information that can be transmitted by these dynamics.
Local Agglomeration and Household Mortgage Debt
Authors: Chen Fengqin Freya , Saffar Walid , Shang Longfei 
Published: September 2024

Using detailed household data, we find that households working in locally agglomerated economies have high mortgage loans and are more likely to have mortgage loans. Channel testing shows that local agglomeration increases housing and mortgage demand as well as mortgage supply. The increase in mortgage loans is driven by purchases of larger houses and smaller down payments. Mechanism analyses document that local agglomeration affects mortgage loans by increasing career upward potential and providing downside protection. Specifically, we find that the impact of local agglomeration is stronger for skilled employees with enhanced prospects. In addition, local agglomeration weakens the negative relation between unemployment and mortgage loans, which supports the downside-protection role of local agglomeration. These results hold under instrumental variables analysis, difference-in-difference analysis, and a set of robustness checks. Overall, our findings highlight the importance of local labor market composition in household mortgage debt. This paper was accepted by Kay Giesecke, finance. Funding: F. F. Chen acknowledges the financial support provided by the Fundamental Research Funds for the Central Universities; the MOE Project of Key Research Institute of Humanities and Social Science in University [Grant 22JJD790094]; and the 111 Project [Grant B18033]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.03486 .
Design and performance of a dual-band plasmonic perfect absorber for infrared refractive index sensing
Authors: Zahra Tazeen , Mohemine M. Abdul , Syed Aqeel A. , Liu Fengguang , Ali Wajid , Muhammad Zahir 
Published: September 2024

In this study, we introduce what we believe is an innovative design for a plasmonic perfect absorber (PPA) that is based on half-cut disk resonator metamaterials. This design exhibits remarkable stability and versatility, demonstrating effective functionality across a wide range of incident angles for both transverse electric (TE) and transverse magnetic (TM) polarization. The distinct operational characteristics of the PPA are highlighted by the presence of two corresponding absorption peaks at wavelengths of 870 and 1599 nm, where it achieves outstanding maximum absorption rates of 98.99% and 97.5%, respectively. The design’s ultra-narrow resonance peaks are indicative of its high-quality factors, which are vital for enhancing sensitivity in plasmonic sensory applications. This characteristic renders our PPA an exceptional candidate for refractive index (RI) sensing, where precision is critical. The dual-band perfect absorber (PA)-based sensor demonstrates significant RI sensitivity, with values approximately equal to 365 nm/RIU at the first absorption peak and 733 nm/RIU at the second. Our findings elucidate the exceptional potential inherent in this novel dual-band perfect absorber design. The versatility and efficiency across varied applications not only contribute to the existing body of knowledge but also pave the way for future advancements in plasmonic sensor technologies and metamaterial research.
Ultra-compact silicon nitride dual-polarization mode converter for visible light demonstrated on a thinned 320  nm silicon wafer
Authors: Alkaliby Ali M. , Nasr Mohamed E. , El-Khobby Heba A. , Abu-Elmaaty Basma E. 
Published: September 2024

A dual-polarization higher-order mode converter is proposed for visible light, which operates within the (400–700) nm range, to enhance data capacity in on-chip visible light communication systems. The proposed structure is optimized at wavelengths of 410 nm, 560 nm, and 660 nm to cover the entire visible spectrum. These three optimized designs, in particular, have an intrinsic property wherein they can be optimized to simultaneously convert both polarized fundamental (TE0) and fundamental (TM0) modes to the second higher-order (TE2) and (TM2) modes, providing significant advantages for hybrid multiplexing systems like PDM-MDM and PDM-WDM schemes. The mode converters are constructed on a silicon nitride waveguide. This waveguide is etched and filled with silicon dioxide material to create two dielectric substrips, followed by an additional rectangle shape etched using the same process into the propagating waveguide. This alteration enhances insertion loss and diminishes crosstalk to the fundamental mode. The devices achieve a broad operating bandwidth of approximately 100 nm while maintaining a compact footprint of only 1µm×1.754µm for the entire device at the center wavelength of 560 nm. Upon optimizing the suggested structure, a TE0-to-TE2 mode converter with a modal conversion efficiency of 94% is designed at the wavelength of 410 nm. The insertion loss is 0.6025 dB, and the crosstalk with the transverse electric fundamental mode TE0 is 35 dB. The reported devices feature a straightforward structure with low insertion loss and minimal crosstalk.
Der gut strukturierte Tod
Authors: Baur Kilian 
Published: September 2024

Abstract

Based on the example of King Conrad I’s death, this paper wants to contribute to the question of how medieval historiography chose and arranged its contents. It postulates that chroniclers narrated their histories just like medieval authors of fictional literature by using plot schemes. Before King Conrad I died, Ottonian sources tell us, he had called for his brother and designated the Saxonian Duke Henry I king. Former research saw vast similarities between the sources as either evidence for their reliability, as textual references, or regarded them as written result of an oral tradition at the Ottonian court. A comparison with several ( East-/West- ) Franconian and English narratives about other rulers’ deaths ( e. g. Pepin the Younger, William the Conqueror or Saladin ) shows us that not only Ottonian, but chroniclers in general used the same textual elements, which they arranged in a similar order. One reason for this might be references to the Bible and hagiography. However, since there are no obvious linguistic borrowings tangible between the narratives, the death of Conrad I in the Ottonian sources can be interpreted as a variation of narratives, based on a more widespread scheme used probably all over Latin Europe. This scheme was distributed in different ways: by the use of textual models, but also by the adaption of oral narratives.
Global existence and extinction for a fast diffusion p-Laplace equation with logarithmic nonlinearity and special medium void
Authors: Liu Dengming , Chen Qi 
Published: September 2024

Abstract
This article is devoted to the global existence and extinction behavior of the weak solution to a fast diffusion

p

p

-Laplace equation with logarithmic nonlinearity and special medium void. By applying energy estimates approach, Hardy-Littlewood-Sobolev inequality, and some ordinary differential inequalities, the global existence result is proved and the sufficient conditions on the occurrence of the extinction and nonextinction phenomena are given.
Semarang Business Incubator and Commercial Space Center with Sustainable Architecture Design
Authors: Ilham Rendi Noor , Setyowati Wiwit , Prihanto Teguh , Wibowo Ardiyan Adhi 
Published: September 2024

Increasingly, Semarang City is experiencing significant MSME business growth. Judging from the economic, social, and environmental problems in this city, everyone is competing in advancing their region. With MSMEs, there are various entities that benefit, such as business owners and other people. These benefits can be in the form of financial benefits that can be a solution to problems in Semarang City, namely poverty and unemployment. The more income-generating entities, the faster economic problems are resolved. Therefore, a forum is needed that can be a place for business people, both old and new business people, to improve their therapy in business. The architectural planning and design program carried by the author is the design of "Semarang Business Incubator and Commercial Space Center with Sustainable Architecture Design Approach". Sustainable Architecture was chosen because in planning a building must have the concept of sustainability by managing waste and utilizing resources optimally. In addition, the use of environmentally friendly materials can also keep the ecosystem around the building maintained and unpolluted. Therefore, this building is expected to be the spearhead in overcoming three main problems in Semarang City, namely, economic problems, social problems, and environmental problems which if not immediately addressed will become a boomerang for the government and citizens of Semarang City.