bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Small Reimbursement Changes Enough to Change Cancer Care? Reimbursement Variation in Prostate Cancer Treatment
Authors: Ellis Shellie D. , Chen Ronald C. , Dusetzina Stacie B. , Wheeler Stephanie B. , Jackson George L. , Nielsen Matthew E. , Carpenter William R. , Weinberger Morris 
Published: April 2016

Purpose: The Centers for Medicare and Medicaid Services recently initiated small reimbursement adjustments to improve the value of care delivered under fee-for-service. To estimate the degree to which reimbursement influences physician decision making, we examined utilization of gonadotropin-releasing hormone (GnRH) agonists among urologists as Part B drug reimbursement varied in a fee-for-service environment. Methods: We analyzed treatment patterns of urologists treating 15,128 men included in SEER-linked Medicare claims who were diagnosed with localized prostate cancer between January 1, 2000, and December 31, 2003. We calculated a reimbursement generosity index to measure differences in GnRH agonist reimbursement among regional Medicare carriers and over time. We used multilevel analysis to control for patient and provider characteristics. Results: Among urologists treating early-stage and lower grade prostate cancer, variation in reimbursement was not associated with overuse of GnRH agonists from 2000 to 2003, a period of guideline stability (odds ratio, 1.00; 95% CI, 0.99 to 1.00). Conclusion: Small differences in androgen-deprivation therapy reimbursement generosity were not associated with differential use. Fee-for-service reimbursement changes currently being implemented to improve quality in fee-for-service Medicare may not affect patterns of cancer care.
Clinical Trial Accrual Targeting Genomic Alterations After Next-Generation Sequencing at a Non-National Cancer Institute–Designated Cancer Program
Authors: Mantripragada Kalyan C. , Olszewski Adam J. , Schumacher Andrew , Perez Kimberly , Birnbaum Ariel , Reagan John L. , Mega Anthony , Khurshid Humera , Bartley Carolyn , Lombardo Alise , Rossiter Rachael , Papa Alessandro , Bakalarski Pamela , Safran Howard 
Published: April 2016

Purpose: Successful clinical trial accrual targeting uncommon genomic alterations will require broad national participation from both National Cancer Institute (NCI)–designated comprehensive cancer centers and community cancer programs. This report describes the initial experience with clinical trial accrual after next-generation sequencing (NGS) from three affiliated non–NCI-designated cancer programs. Materials and Methods: Clinical trial participation was reviewed after enrollment of the first 200 patients undergoing comprehensive genomic profiling by NGS as part of an institutional intuitional review board–approved protocol at three affiliated hospitals in Rhode Island and was compared with published experience from NCI-designated cancer centers. Results: Patient characteristics included a median age of 64 years, a median of two lines of prior therapy, and a predominance of GI carcinomas (58%). One hundred sixty-four of 200 patients (82%) had adequate tumor for NGS, 95% had genomic alterations identified, and 100% had variants of unknown significance. Fifteen of 164 patients (9.2%) enrolled in genotype-directed clinical trials, and three patients (1.8%) received commercially available targeted agents off clinical trials. The reasons for nonreceipt of NGS-directed therapy were no locally available matching trial (48.6%), ineligibility (33.6%) because of comorbidities or interim clinical deterioration, physician's choice of a different therapy (6.8%), or stable disease (11%). Conclusion: This experience demonstrates that a program enrolling patients in specific targeted agent clinical trials after NGS can be implemented successfully outside of the NCI-designated cancer program network, with comparable accrual rates. This is important because targetable genes have rare mutation rates and clinical trial accrual after NGS is low.
A Possible Link Between Parathyroid Hormone Secretion and Local Regulation of GABA in Human Parathyroid Adenomas
Authors: Hong A Ram , Kim Young A , Bae Jae Hyun , Min Hye Sook , Kim Jung Hee , Shin Chan Soo , Kim Seong Yeon , Kim Sang Wan 
Published: April 2016

Abstract

Context:
γ-Aminobutyric acid-B receptor 1 (GABABR1) forms a heterodimeric complex with calcium-sensing receptor (CaSR) in human brain tissue. However, the expression and implication of GABABR1 in human parathyroid adenoma has not yet been examined.

Objective:
The objective of the study was to examine a possible link between GABABR1 and PTH secretion in human parathyroid adenoma

Design and Methods:
Sixty-five patients who underwent parathyroidectomy for primary hyperparathyroidism (PHPT) and 29 control patients with normal parathyroid glands were retrospectively included. All patients diagnosed with PHPT had parathyroid adenomas. We evaluated the protein expression of GABABR1, glutamic acid decarboxylase 65/67 (GAD65/67), and various factors proposed as regulators of PTH secretion including CaSR, vitamin D receptor (VDR), CYP24A1, CYP27B1, fibroblast growth factor, and α-klotho in parathyroid tissues from patients with parathyroid adenomas using immunohistochemistry.

Results:
Expressions of CaSR, GABABR1, and VDR were significantly lower in PHPT patients than in control subjects (P &lt; .001 for CaSR and GABABR1; P = .006 for VDR). Protein expression of GAD65/67, which indicates local production and regulation of GABAergic pathway, was significantly increased in PHPT (P &lt; .001). There were no significant differences in CYP24A1, CYP27B1, fibroblast growth factor, and α-klotho expression between the two groups. Expression of GAD65/67 was significantly correlated with VDR, CYP24A1, CYP27B1, and α-klotho in PHPT (all P &lt; .01) but not in the control groups. CaSR expression was positively associated with serum phosphorus level (r = 0.274, P = .029) and GAD65/67 was negatively correlated with serum PTH level (r = −0.342, P = .005).

Conclusions:
Local production and action of GABA may be regulated in human parathyroid adenomas. This suggests a possible link between PTH secretion and local regulation of GABA in parathyroid adenomas.
Functional characterisation of human synaptic genes expressed in theDrosophilabrain
Authors: Zografos Lysimachos , Tang Joanne , Hesse Franziska , Wanker Erich E. , Li Ka Wan , Smit August B. , Davies R. Wayne , Armstrong J. Douglas 
Published: April 2016

ABSTRACTDrosophila melanogaster is an established and versatile model organism. Here we describe and make available a collection of transgenic Drosophila strains expressing human synaptic genes. The collection can be used to study and characterise human synaptic genes and their interactions and as controls for mutant studies. It was generated in a way that allows the easy addition of new strains, as well as their combination. In order to highlight the potential value of the collection for the characterisation of human synaptic genes we also use two assays, investigating any gain-of-function motor and/or cognitive phenotypes in the strains in this collection. Using these assays we show that among the strains made there are both types of gain-of-function phenotypes investigated. As an example, we focus on the three strains expressing human tyrosine protein kinase Fyn, the small GTPase Rap1a and human Arc, respectively. Of the three, the first shows a cognitive gain-of-function phenotype while the second a motor gain-of-function phenotype. By contrast, Arc, which has no Drosophila ortholog, shows no gain-of-function phenotype.
Prevalence and characteristics of lymphoedema at a wound-care clinic
Authors: Wang W. , Keast D.H. 
Published: April 2016

Objective: Lymphoedema is estimated to affect up to 300,000 Canadians but remains underrecognised and undertreated. A retrospective chart review was conducted to determine the clinical characteristics and treatment practices of lymphoedema in a Canadian wound care clinic. Method: Data were collected retrospectively from dictated clinic notes of 326 lymphoedema patients at a wound clinic in a regional rehabilitation hospital. Results: The mean age (±SD) of diagnosis was 66.8 (±15.5). Patients had 7.3 (±3.3) comorbidities and took 8.4 (±4.6) concomitant medications. The most common comorbidities were venous disease (73%), hypertension (60%), and obesity (46%). Clinic patients were less likely to be women, have arm lymphoedema, or have cancer-related aetiology compared with previous studies, reflecting a two-tiered model of care delivery in the area. Treatments prescribed by the clinic were consistent best practice recommendations for conservative treatment. Conclusion: A significant proportion of the wound clinic's patients had lymphoedema. Lack of resources, lack of awareness among primary care providers, and patient adherence are barriers to lymphoedema care.
Making sense of Chinese TV’s past, present and future
Authors: Zhao Jing Jamie 
Published: April 2016

Abstract
Television and The Modernization Ideal in 1980S China: Dazzling the Eyes, Huike Wen (2014) Lanham, MD: Lexington Books, 155 pp., ISBN: 9780739178867, h/bk, $75.00
Family Revolution: Marital Strife in Contemporary Chinese Literature and Visual Culture, Hui Faye Xiao (2014) Seattle, WA: The University of Washington Press, 247 pp., ISBN: 9780295993492, h/bk, $75.00
Staging Corruption: Chinese Television and Politics, Ruoyun Bai (2015) Hong Kong: Hong Kong University Press, 276 pp., ISBN: 9789622091832, h/bk, $99.00
Chinese Television in The Twenty-First Century: Entertaining the Nation, Ruoyun Bai and Geng Song (Eds) (2015), New York: Routledge, 200 pp., ISBN: 9780415745123, h/bk, $145.00
The aesthetics, creativity and craftsmanship of fourth graders’ compositions
Authors: Downton Michael P. 
Published: April 2016

Abstract
Fourth-grade students (N=36) engaged in a twenty-hour computer-aided composition curriculum using the computer software Impromptu. Analysis of the compositions used Hickey’s general assessment rubric for composition that specifically targets the composition’s creativity, craftsmanship and aesthetic appeal. Compositions were evaluated on a scale of 1–4 (1 meaning ‘Needs Work’ and 4 meaning ‘Terrific!’), and a repeated-measure analysis of variance (ANOVA) was used to measure changes at the beginning, middle and end of the study. Findings indicate that students do not simply tinker with their composition but pay attention to how their song is put together over time, which is a trait seen in professional composers as well. However, this may be a result of the pedagogical approaches used during the curriculum. Limitations and implications are discussed.
Designing Patient-facing Health Information Technologies for the Outpatient Settings: A Literature Review
Authors: Yang Yushi , Asan Onur 
Published: April 2016

Introduction: The implementation of health information technologies (HITs) has changed the dynamics of doctor–patient communication in outpatient settings. Designing patient-facing HITs provides patients with easy access to healthcare information during the visit and has the potential to enhance the patient-centred care. Objectives: The objectives of this study are to systematically review how the designs of patient-facing HITs have been suggested and evaluated, and how they may potentially affect the doctor–patient communication and patient-centred care. Method: We conducted an online database search to identify articles published before December 2014 relevant to the objectives of this study. A total of nine papers have been identified and reviewed in this study. Results: Designing patient-facing HITs is at an early stage. The current literature has been exploring the impact of HITs on doctor–patient communication dynamics. Based on the findings of these studies, there is an emergent need to design more patient-centred HITs. There are also some papers that focus on the usability evaluation of some preliminary prototypes of the patient-facing HITs. The design styles of patient-facing HITs included sharing the health information with the patients on: (1) a separate patient display, (2) a projector, (3) a portable tablet, (4) a touch-based screen and (5) a shared computer display that can be viewed by both doctors and patients. Each of them had the strengths and limitations to facilitate the patient-centred care, and it is worthwhile to make a comparison of them in order to identify future research directions. Conclusion: The designs of patient-facing HITs in outpatient settings are promising in facilitating the doctor-patient communication and patient engagement. However, their effectiveness and usefulness need to be further evaluated and improved from a systems perspective.
The Manufacturing of Textile Products with Incorporated Electrodes
Authors: Curteza Antonela , Cretu Viorica , Macovei Laura , Poboroniuc Marian 
Published: April 2016

Abstract
One of the main causes of disabling deficits is neurological affections. Many times, the evolution of the condition leads to a diminution of the patient’s life quality. Functional electrical stimulation (FES) is part of the neurological rehabilitation process that comprises all the actions one can take in order to increase a patient’s integration and autonomy degree from a social and financial point of view. FES is a method based on substituting the commands that are usually transmitted by the nervous system with an electric impulse. The use of such a method on different body areas required the development of some adequate devices, starting with the stimulator itself and finishing with the way in which the stimulus is conveyed to the effectors. Textile materials that incorporate sensors and, mainly, the clothing products that have such components in their structure, have a high applicability potential; they can be used for preventing illnesses and for the rehabilitation of seniors, of people who are confined to bed, sportsmen, people who suffer from long-term illnesses, disabled people, thus diminishing the time one spends in the hospital. A possible solution for manufacturing incorporated textile electrodes consists in the insertion of some electro-conductive yarns onto textile surfaces by using a variety of technologies. The project approaches the use of knitting, a widespread textile technology. The incorporated knitted electrodes were accomplished by applying the knitting technology on single circular small diameter machines. Thus, we were able to obtain a variety of knitted articles as two-dimensional or three-dimensional tubular knitted fabric. Their dimensions, structures, and parameters correspond to the typo-dimensions of the human body and to the purpose for which the clothing product was designed. The knitted versions were tested by using a Microstim2v2 (PW = 300 μs, 40 Hz) neurostimulator for which the current intensity was adjusted to approx. 30 mA.
Experimental investigation of commercial small diameter dental implants in porcine mandibular segments
Authors: Hasan Istabrak , Heinemann Friedhelm , Schwegmann Monika , Keilig Ludger , Stark Helmut , Bourauel Christoph 
Published: April 2016

AbstractSmall diameter (mini) dental implants have become more popular in recent years as alternatives to classical implant treatment in clinical cases with critical bony situations. However, an in-depth scientific analysis of the mechanical and biomechanical effects of small diameter implants has not yet been published. The aim of the present study was to investigate experimentally different commercial mini implants by measuring their displacements under immediate loading. Twelve commercially available mini implants were measured. Implants were inserted into porcine mandibular segments and loaded by means of a predefined displacement of 0.5 mm of the loading system. The implants were loaded at an angle of 30° to the implant long axis using the self-developed biomechanical hexapod measurement system. Implant displacements were registered. The experimental results were compared to the numerical ones from a previous study. Measured implant displacements were within the range of 39–194 μm. A large variation in the displacements was obtained among the different implant systems due to the different designs and thread profiles. Comparing experimental and numerical results, the displacements that were obtained numerically were within the range of 79–347 μm. The different commercial mini implants showed acceptable primary stability and could be loaded immediately after their insertion.
Optimizing Signal De-Noising Algorithm for Acoustic Emission Leakage of Wavelet
Authors: Wang Xin-Hua , Jiao Yu-Lin , Niu Yong-Chao , Yang Jie 
Published: April 2016

Abstract
Traditional wavelet denoising method cannot eliminate complex high-pressure pipe signals effectively. In the updated wavelet adaptive algorithm, this thesis defines the constraints in order to reconstruct the signals accurately. According to the minimum mean square error criterion, the results predict the weight coefficient and get the optimal linear predictive value. Adopting the improved algorithm under the same condition, this thesis concluded that Db6 increased the complexity of wavelet algorithm by 50% by comparative experiments. It will be more conducive to the realization of hardware and the feasibility of real-time denoising. Dual adaptive wavelet denoising method improved SNR by 50%. This denoising method will play a key role in the detection rate of high-pressure pipe in the online leakage detection system.
Analysis of CO2 concentration distribution inside and outside small boiler plants
Authors: Cichowicz Robert , Wielgosiński Grzegorz , Targaszewska Agata 
Published: April 2016

Abstract
Analysis of the distribution of CO2 concentrations was performed for a water-and-steam boiler plant located in a detached building supplying thermal energy to a hospital. The boiler plant was equipped with two low-temperature boilers and one high-temperature steam boiler. The maximum thermal energy demand of the hospital was 4280, 3500 kW of which came from the hot-water boilers and the remaining 780 kW from the steam boiler. Due to the operating system there were no permanent job positions in the boiler plant. Servicing consisted only in the supervision, periodic adjustment and maintenance of the equipment. These kinds of working conditions release the employer from the necessity to perform tests and measurements of working conditions in such a building. On the other hand, continuous measurements are made because of the installation safety and emissions of pollutants into the environment. The article presents results of the measurements and analysis of the distribution of CO2 concentrations inside and outside a small boiler plant, due to which it was found that the level of carbon dioxide concentration did not depend on the ambient air temperature. The resulting values are similar regardless of whether the measurements were taken in December 2012 or April 2013. However, there is an evident impact of seasons on the concentrations in the indoor air associated primarily with the demand for heat during the given period, the stay of people in the workplace and the number of working devices.
Spatial and chemical patterns of PM2.5 - differences between a maritime and an inland country
Authors: Werner Małgorzata , Kryza Maciej , Dore Anthony J. 
Published: April 2016

Abstract
The Fine Resolution Atmospheric Multi-pollutant Exchange model was used to calculate the mean annual concentration of PM2.5 at a resolution of 5 km × 5 km for the United Kingdom (UK) and Poland for the year 2007. The modelled average PM2.5 concentration is higher for Poland than the UK and amounts to 9.2 µg · m−3 and 5.6 µg · m−3, respectively. The highest concentrations concern London and coastal areas (due to the sea salt contribution) for the UK and urban agglomerations in the case of Poland. Maximum values occurring close to the UK coastline can reach 18 µg · m−3. The average contribution of natural particles amounts to 34 and 20% of total PM2.5 concentration, respectively for the UK and Poland. Among anthropogenic particles for both countries the highest contribution falls on secondary inorganic aerosols and the lowest contribution is for secondary organic aerosols.
Suitability of combined sewers for the installation of heat exchangers
Authors: Stransky David , Kabelkova Ivana , Bares Vojtech , Stastna Gabriela , Suchorab Zbigniew 
Published: April 2016

Abstract
The present paper deals with the classification of the suitability of combined sewers for the installation of heat exchangers and with assessment of the theoretical potential of wastewater in the sewer system for heating of buildings. A classification scheme involving criteria like theoretically available heat, sewer diameter, number of the heat exchanger parallel modules in the sewer cross-section, hydraulic conditions (hydraulic capacity of the sewer, pressurized flow), and potential fouling by biofilm growth was developed. First, individual sewers in the pilot catchment were assessed based on monitoring the flow characteristics and wastewater temperatures and on pipe flow modelling. Second, connectivity of the suitable and partly suitable sewers was examined with respect to the length necessary for the installation of the heat exchanger with the minimum required power of 100 kW. For the continuous sewer sections, the maximum potential power was calculated. The presented approach is generally applicable, however, for other heat exchanger types and other climatic and economic conditions, values of the suitability criteria for the heat exchanger installation must be adapted.
Treatment of dairy waste by anaerobic co-digestion with sewage sludge
Authors: Pilarska Agnieszka A. , Pilarski Krzysztof , Witaszek Kamil , Waliszewska Hanna , Zborowska Magdalena , Waliszewska Bogusława , Kolasiński Marek , Szwarc-Rzepka Karolina 
Published: April 2016

Abstract
The results of anaerobic digestion (AD) of buttermilk (BM) and cheese whey (CW) with a digested sewage sludge as inoculum is described. The substrate/inoculum mixtures were prepared using 10% buttermilk and 15% cheese whey. The essential parameters of the materials were described, including: total solids (TS), volatile solids (VS), pH, conductivity, C/N ratio (the quantitative ratio of organic carbon (C) to nitrogen (N)), alkalinity, chemical oxygen demand (COD). The potential directions of biodegradation of the organic waste types, as used in this study, are also presented. Appropriate chemical reactions illustrate the substrates and products in each phase of anaerobic decomposition of the compounds that are present in buttermilk and cheese whey: lactic acid, lactose, fat, and casein. Moreover, the biogas and biomethane production rates are compared for the substrates used in the experiment. The results have shown that buttermilk in AD generates more biogas (743 m3/Mg VS), including methane (527 m3/Mg VS), when compared with cheese whey (600 m3/Mg VS, 338 m3/Mg VS for biogas and methane, respectively).