bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grammar Learning Strategy (GLS): Male and Female EFL Students’ Preferences
Authors: Yuliana Yuliana , Heriyanti  , Rinda Hardianti  , Tsalisa Syifa Afia  
Published: September 2024

This research compares the preference for Grammar Learning Strategies (GLS) between male and female EFL students of Universitas Muhammadiyah Sorong. The research aims to identify the preferred strategies for learning grammar among males and females students and determine if a statistically significant disparity exists in preference for grammar learning strategies among males and females students. A total of 70 students, comprising 35 males and 35 females, took part in the research. They were obtained from 48% of the entire population. A Simple Random Technique was employed to randomly select 35 males and 35 female students from all the classes. The data were gathered using Pawlak's Grammar Learning Strategy Inventory (GLSI) questionnaire. The acquired data were analyzed using the Independent sample t-test procedure using SPSS version 29. The results indicate that male students preferred social grammar learning strategies (GLS). The preference for cognitive grammar learning strategies (GLS) was found among female students, particularly for dealing with Corrective Feedback (CF). Male and female English as a Foreign Language (EFL) Students at Universitas Muhammadiyah Sorong did not differ significantly with regard to their preferred strategies for learning grammar. Based on the analysis of the data, the researchers found that there was no statistically significant distinction between males and females regarding the strategies they preferred to learn grammar. Both males and females are utilizing a Grammar Learning Strategy at a medium level.
Efektivitas Media Komik Digital dalam Pembelajaran Perubahan Lingkungan terhadap Hasil Belajar Siswa di SMA Kristen Abdi Wacana Pontianak
Authors: Kristina  , Qurbaniah Mahwar , Mukti Rahayu Hanum 
Published: September 2024

Penelitian ini dilatarbelakangi oleh rendahnya hasil belajar siswa pada mata pelajaran Biologi yang ditandai dengan nilai yang belum mencapai KKM di kelas X IPA SMA Kristen Abdi Wacana Pontianak. Tujuan dilakukan penelitian ini adalah untuk mengukur efektivitas media komik digital terhadap hasil belajar siswa kelas X. Metode penelitian yang digunakan adalah metode eksperimen. Pengambilan sampel menggunakan teknik sampling jenuh. Sampel penelitian ini adalah semua siswa kelas X IPA SMA Kristen Abdi Wacana Pontianak. Alat pengumpulan data menggunakan soal tes pilihan ganda dan lembar observasi. Analisis data menggunakan SPSS 23.0 for windows. Hasil rata-rata nilai pretest dan posttest pada kelas kontrol berturut-turut sebesar 28,33 dan 69,16 serta rata-rata nilai pretest dan posttest pada kelas eksperimen berturut-turut sebesar 30 dan 79,23. Diperoleh angka signifikansi hasil Uji U-Mann Whitney hasil belajar sebesar 0.021(0.021 < 0.05), maka Ha dalam penelitian ini diterima. Hasil perhitungan Effect Size diperoleh nilai sebesar 3.33 (tergolong tinggi). Berdasarkan hasil penelitian yang diperoleh dapat disimpulkan bahwa terdapat pengaruh penggunaan media komik digital dalam pembelajaran perubahan lingkungan terhadap hasil belajar siswa di SMA Kristen Abdi Wacana Pontianak.

Kata kunci: Hasil Belajar, Komik Digital, Perubahan Lingkungan
Pengaruh Model Pembelajaran Jelajah Alam Sekitar (JAS) Menggunakan QR-Code Terhadap Hasil Belajar Siswa di SMAN 1 Simpang Hilir
Authors: Sonia  , Setiadi Anandita Eka , Rahayu Hanum Mukti 
Published: September 2024

JAS digunakan untuk memanfaatkan lingkungan alam sekitar sebagai objek pengetahuan. Penelitian ini bertujuan untuk mengetahui pengaruh model JAS menggunakan QR-Code terhadap hasil belajar siswa di SMAN 1 Simpang Hilir. Penelitian ini menggunakan metode Quasi eksperimen, pendekatan kuantitatif. Hasil penelitian kelas eksperimen menghasilkan rata-rata nilai pretest 22,36, rata-rata nilai posttest 85,76. Kelas kontrol nilai pretest 24,67, nilai posttest 56,01. Data dianalisis secara statistik menggunakan uji normalitas dengan Shapiro Wilk dikelas eksperimen memperoleh hasil nilai pretest dengan sig 0,141>0,005 dan nilai posttest 0,056>0,005, kelas eksperimen berdistribusi normal, dan pada kelas kontrol data pretest nilai sig 0,000<0,005 dan posttest sig 0,000<0,005, pada kelas kontrol tidak normal. Dilakukan uji U Mann-Whitney sig 0,001<0,005, tidak terdapat perbedaan signifikan dengan model JAS menggunakan QR-Code. Uji Effet Size memperoleh hasil 1,07 (Kreteria Tinggi), terdapat pengaruh dengan model JAS Menggunakan QR-Code.
Occlusion of functional high-volume intra-atrial shunts in older patients after embolic stroke of undetermined source
Authors: Schrader Helene , Boldt Leif-Hendrik , Parwani Abdul S. , Blaschke Florian , Wiedenhofer Julia M. , Trippel Tobias D. , Hindricks Gerhard , Starck Christoph , Dreger Henryk , Sherif Mohammad , Primessnig Uwe 
Published: September 2024

BackgroundIntra-atrial shunts are associated with an elevated risk of embolic stroke of undetermined source (ESUS). Percutaneous occluder implantation is recommended as secondary prevention in younger patients. This study aims to compare the outcome after shunt occlusion between younger and older patients with a history of presumed paradox embolism and to evaluate the impact of high-volume shunting in an elderly population.MethodsWe conducted a single-center, retrospective, observational study, involving 187 patients who underwent interventional percutaneous PFO or ASD occlusion at our center between 2013 and 2023.ResultsThe mean age of participants was 51.8 ± 11.8 years, with 76 patients aged ≤50 years and 111 patients aged &gt;50 years. Older patients presented more cardiovascular risk factors. The presence of atrial septum aneurysm or large shunting was evenly distributed (ASA 26.3% vs. 28.8%, p = 0.833, mean shunt defect size 6.67 vs. 7.23 mm, p = 0.151). There were no significant differences in procedural or intrahospital complications. The event rate during the 6-month follow-up was low. Recurrence of arterial embolism occurred in 1.6% of the younger and 3.8% of the older patients (p = 0.817). Comparison of high-volume shunts (defect size ≥10 mm or passage ≥20 bubbles during bubble study) with low-volume shunts in this elderly cohort with a mean age ≥50 years showed no significant difference in outcomes. There was a statistically non-significant trend toward a higher rate of residual shunt at the end of the procedure in the high-volume shunt group (2.9% vs. 9.8%, p = 0.0894). This difference was not observed at the 6-month follow-up anymore (14.5 vs. 12.1%, p = 0.628). Two unsuccessful implantation attempts were reported in the high-volume shunt group, while none were observed in the low-volume shunt group (p = 0.372). No intervention-related deaths occurred in this patient cohort during follow-up.ConclusionOcclusion of relevant, intra-atrial shunting is a safe and effective option for secondary prevention of cryptogenic embolism in patients over 50 years of age. The beneficial outcome was irrespective of a high-volume shunting before implantation.
Temperature management in acute type A aortic dissection treatment: deep vs. moderate hypothermic circulatory arrest. Is colder better?
Authors: Abdulwahab Hend Abdulwahab Muftah , Kolashov Alish , Haneya Assad , Klump Hannes , Moza Ajay , Arab Mohamad Fateh , Shoaib Mohammed , Zayat Rashad , Khattab Mohammad Amen 
Published: September 2024

IntroductionThe impact of different degrees of hypothermia in patients undergoing type A aortic dissection (TAAD) repair remains controversial. The purpose of this study was to compare the clinical outcomes of patients who received deep hypothermic circulatory arrest (DHCA) (&lt;20°C) and those of patients who received moderate hypothermic circulatory arrest (MHCA) (20–28°C).MethodsBetween January 2011 and December 2020, 143 patients underwent surgical treatment for TAAD with CA and unilateral antegrade selective cerebral perfusion (uSCP). In this retrospective analysis, we evaluated the clinical outcomes of 143 individuals (103 who received DHCA vs. 40 who received MHCA). The primary outcome was the composite of major events (CMEs) including delirium, acute kidney injury (AKI), and in-hospital mortality. The secondary outcomes were overall mortality, bleeding, rethoracotomy, and length of intensive care unit (ICU) stay, among other things.ResultsCompared with the MHCA group, the DHCA group presented a greater incidence of postoperative complications, as follows: AKI (26 (25.2%) vs. 3 (7.5%), p = 0.020), delirium (23 (22.3%) vs. 2 (5%), p = 0.014), re-exploration rate (21 (20.4%) vs. 2 (5.0%), p = 0.024), and prolonged intensive care unit (ICU) stay (7.8 (4.4, 14.1) vs. 5.7 (2.4, 10) days, p = 0.019). The median cardiopulmonary bypass time (255 (210, 280) vs. 210 (190, 251) min, p = 0.010) and median cross-clamp time (140 (110, 180) vs. 125 (100, 160) min, p = 0.023) were significantly longer in the DHCA group. The German Registry for Acute Aortic Dissection Type A (GERAADA) score was significantly higher in the MHCA group (22.7 ± 9.1 vs. 19 ± 7.2, p = 0.012). The adjusted odds ratio for CME in the MHCA group was 0.78 (95% CI: 0.52–1.17, p = 0.001). The use of MHCA demonstrated a protective effect on reducing postoperative delirium (OR: 0.28, 95% CI: 0.14–0.46, p &lt; 0.01) and postoperative AKI (OR: 0.29, 95% CI: 0.14–0.49, p &lt; 0.01). Overall survival after two years did not differ between the two groups (log-rank, p = 0.16).ConclusionThe principal findings of our study indicate that DHCA elevates the risk of postoperative AKI and delirium. As a result, the duration of hospitalization and intensive care unit stay was markedly extended. Consequently, MHCA should be favored over DHCA when the clinical circumstances permit, since DHCA remains a secure alternative in intricate dissection instances.
The impact of successful chronic total occlusion percutaneous coronary intervention on clinical outcomes: a tertiary single-center analysis
Authors: Will Maximilian , Schwarz Konstantin , Aufhauser Simone , Leibundgut Gregor , Schmidt Elisabeth , Mayer David , Vock Paul , Borovac Josip A. , Kwok Chun Shing , Lamm Gudrun , Mascherbauer Julia , Weiss Thomas 
Published: September 2024

BackgroundThe benefit of chronic total occlusion (CTO)-percutaneous coronary intervention (PCI) is controversial because of a lack of high-quality evidence. We aim to evaluate the impact of CTO-PCI on symptoms, quality of life and mortality.MethodsWe conducted a retrospective single center study of patients with CTO-PCI in a tertiary center in Austria. The study outcomes were Canadian Cardiovascular Society (CCS) angina score, quality of life measured by Seattle Angina Questionnaire (SAQ), and death at median follow up for patients with successful vs. failed CTO-PCI.ResultsA total of 300 patients underwent CTO-PCI for coronary artery disease, of which 252 (84%) were technically successful with median follow up of 3.4 years. There were no significant differences in in-hospital or all-cause mortality, major adverse cardiovascular event, or stent-related complications between the groups of failed and successful CTO-PCI. Among patients with successful CTO-PCI there was a significant improvement in CCS score, which was not found for the group with failed CTO-PCI. Successful reopening was associated with significant benefits of the SAQ domains of angina with stressful activity [3.7 ± 0.9 vs. 3.1 ± 0.5, p = 0.004, use of nitrates (4.7 ± 0.5 vs. 3.0 ± 1.0) p = 0.005] and satisfaction from angina relief (4.4 ± 1.1 vs. 3.6 ± 1.4 p &lt; 0.001).ConclusionWhile there was no significant difference in mortality, successful CTO-PCI was associated with greater reduction in angina and the use of nitrates compared to unsuccessful CTO-PCI.
Shared diagnostic genes and potential mechanisms between polycystic ovary syndrome and recurrent miscarriage revealed by integrated transcriptomics analysis and machine learning
Authors: He Juanjuan , Liu Ahui , Shen Haofei , Jiang Yanbiao , Gao Min , Yu Liulin , Du Wenjing , Zhang Xuehong , Fu Fen 
Published: September 2024

ObjectiveMore and more studies have found that polycystic ovary syndrome (PCOS) is significantly associated with recurrent spontaneous abortion (RSA), but the specific mechanism is not yet clear.MethodsBased on the GEO database, we downloaded the PCOS (GSE10946, GSE6798 and GSE137684) and RSA (GSE165004, GSE26787 and GSE22490) datasets and performed differential analysis, weighted gene co-expression network (WGCNA), functional enrichment, and machine learning, respectively, on the datasets of the two diseases, Nomogram and integrated bioinformatics analysis such as immune infiltration analysis. Finally, the reliability of the diagnostic gene was verified by external verification and collection of human specimens.ResultsIn this study, PCOS and RSA datasets were obtained from Gene Expression Omnibus (GEO) database, and a total of 23 shared genes were obtained by differential analysis and WGCNA analysis. GO results showed that the shared genes were mainly enriched in the functions of lipid catabolism and cell cycle transition (G1/S). DO enrichment revealed that shared genes are mainly involved in ovarian diseases, lipid metabolism disorders and psychological disorders. KEGG analysis showed significant enrichment of Regulation of lipolysis in adipocytes, Prolactin signaling pathway, FoxO signaling pathway, Hippo signaling pathway and other pathways. A diagnostic gene FAM166 B was obtained by machine learning and Nomogram screening, which mainly played an important role in Cellular component. GSEA analysis revealed that FAM166B may be involved in the development of PCOS and RSA by regulating the cell cycle, amino acid metabolism, lipid metabolism, and carbohydrate metabolism. CIBERSORT analysis showed that the high expression of FAM166 B was closely related to the imbalance of multiple immune cells. Further verification by qPCR suggested that FAM166 B could be used as a common marker of PCOS and RSA.ConclusionsIn summary, this study identified FAM166B as a common biomarker for PCOS and RSA, and conducted in-depth research and analysis of this gene, providing new data for basic experimental research and early prognosis, diagnosis and treatment of clinical diseases.
Effects of aquatic and land high-intensity interval trainings on selected bio- and physiological variables among obese adolescents
Authors: Liao Ting , Zheng Chuanbo , Xue Jungang , Wang Yong “Tai” 
Published: September 2024

BackgroundObesity among adolescents have become a global public health problem. Exercises can effectively improve the bio-physiological factors of obese adolescents. High-intensive interval training (HIIT) has been applied to obese adolescents. Studies have reported that the Aquatic environment may bring the same or more positive exercise effects as the land environment. Therefore, the purpose of this study was to examine the effects of aquatic and land interventions on selected bio-and physiological variables among obese adolescences.MethodsTwenty-eight obese adolescents who met the requirements participated in and completed this study. The participants were randomly assigned to Aquatic HIIT group (n=17) or Land HIIT group (n=11) for a four-week exercise intervention, 3 time/week. Each Intervention program was one-hour long, including 20 minutes of warm-up, 30 minutes of HIIT and 10 minutes of stretching and relaxation. Bio- and physiological variables including Anthropometry and body composition, Physical Function and blood pressure, and Lipid metabolism indexes were collected before and after the Aquatic and Land interventions.ResultsAfter four weeks of exercise interventions, the body mass, BMI, body fat rate, waist circumference, hip circumference and body water content were significantly reduced (p&lt;0.05), and the lean body mass were significantly increased (p&lt;0.05) in both groups. Both group exhibited significant effects in decreasing, systolic blood pressure (p&lt;0.05), diastolic blood pressure (p&lt;0.01), and increasing vital capacity and total energy consumption (p&lt;0.05). The Aquatic HIIT group showed significant effects on reducing Rest heart rate (p&lt;0.05), but no significant changes in Rest heart rate in Land HIIT group (p=0.364). The low-density lipoprotein cholesterol in both groups was significantly decreased (p&lt;0.05). Moreover, the Aquatic HIIT group had significant better improvements (p&lt;0.05) in lean body mass, waist circumference, waist-to-hip ratio, vital capacity and total energy consumption than Land HIIT group did.ConclusionsThe results of the present study demonstrated that in a short-term (4 weeks) both Aquatic and Land HIIT interventions may improve the body composition, physical function, blood pressure and low-density lipoprotein cholesterol (LDL-C) of overweight and obese adolescents. Furthermore, the Aquatic HIIT may be superior than the Land HIIT in weight control among the obese adolescents.
Associations between cardiovascular health and low thyroid function among US adults: a population-based study
Authors: Fang Xiaoxiao , Hu Rui , Fei Shani , Ding Zhiguo , Zhao Jiuli , Shang Jianwei 
Published: September 2024

BackgroundHigher thyroid-stimulating hormone (TSH) amidst normal thyroid hormone (TH) levels may contribute to a negative impact on cardiovascular health (CVH). We sought to probe the associations between Life’s Essential 8 (LE8), a newly revised CVH evaluation, and low thyroid function among US adults.MethodsThe datasets from the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were applied to the study. Low-normal thyroid function and subclinical hypothyroidism (SCH) were both regarded to be low thyroid function. Multivariable logistic regressions were utilized to inquire about the relationship between LE8 and low thyroid function.ResultsAmong the 6,315 participants (age ≥20 years), 1,375 (21.77%) were ascertained to be low thyroid function. After adjusting possible confounders, a higher LE8 score was linked to a lower probability of experiencing low thyroid function (Odds ratio [OR] for each 10-point increase: 0.923 [95% CI, 0.884-0.964]). A similar correlation was found between the health factors score and low thyroid function (OR for each 10-point increase: 0.905 [95% CI, 0.876-0.935]). Also, scoring better on physical activity (PA), body mass index (BMI), blood lipid, blood glucose (BG), and blood pressure (BP) may be conducive to reducing the rates of low thyroid function. Furthermore, subgroup and sensitivity analyses indicated that the negative correlations were generally robust.ConclusionsThe LE8 score and health factors score were nonlinearly and negatively related to the prevalence concerning low thyroid function. Promoting the regulation of optimum CVH levels could work on mitigating the load of low thyroid function and cardiovascular diseases (CVDs).
The effect of window proportions in low-rise residential buildings on annual energy consumption in humid temperate climate (case study: Rasht city in Iran)
Authors: Bagheri Sara , Moradinasab Hossien , Yeganeh Mansour 
Published: September 2024

The proportions of exterior windows in low-rise residential buildings are crucial for optimizing energy consumption. This study investigates and optimizes these proportions for buildings in the temperate climate of Rasht City, Iran. A building was simulated in DesignBuilder software to explore how different window-to-wall ratios affect energy consumption. Using a parametric algorithm, the percentage of windows on each building facade was varied from 10% to 100%, and heating, cooling, and lighting loads were calculated. The results revealed that optimizing window proportions can significantly reduce annual energy consumption. For the north-facing facade, the optimal window-to-wall ratio is between 26% and 33%. On the south side, the most efficient window proportion is 21%–25%, resulting in the lowest energy consumption of 2,102 kWh/m2 per year. The optimal window proportions for the east and west facades are 54%–57%, and 58%, respectively. The study found a strong correlation between energy consumption and the window-to-wall ratio for the south-facing facade, with a correlation coefficient of 0.97. For the north, east, and west facades, the correlation coefficients are 0.72, 0.17, and 0.33, respectively. These findings can predict energy consumption for residential buildings in Rasht and similar climates. Optimizing window proportions is an effective strategy to reduce energy use and enhance residents’ quality of life, applicable to both new constructions and renovations of existing buildings.
Genetic architecture of kernel-related traits in sweet and waxy maize revealed by genome-wide association analysis
Authors: Qu Jingtao , Yu Diansi , Gu Wei , Khalid Muhammad Hayder Bin , Kuang Huiyun , Dang Dongdong , Wang Hui , Prasanna Boddupalli , Zhang Xuecai , Zhang Ao , Zheng Hongjian , Guan Yuan 
Published: September 2024

IntroductionMaize (Zea mays L.) is one of the most important crops worldwide, the kernel size-related traits are the major components of maize grain yield.MethodsTo dissect the genetic architecture of four kernel-related traits of 100-kernel weight, kernel length, kernel width, and kernel diameter, a genome-wide association study (GWAS) was conducted in the waxy and sweet maize panel comprising of 447 maize inbred lines re-sequenced at the 5× coverage depth. GWAS analysis was carried out with the mixed linear model using 1,684,029 high-quality SNP markers.ResultsIn total, 49 SNPs significantly associated with the four kernel-related traits were identified, including 46 SNPs on chromosome 3, two SNPs on chromosome 4, and one SNP on chromosome 7. Haplotype regression analysis identified 338 haplotypes that significantly affected these four kernel-related traits. Genomic selection (GS) results revealed that a set of 10,000 SNPs and a training population size of 30% are sufficient for the application of GS in waxy and sweet maize breeding for kernel weight and kernel size. Forty candidate genes associated with the four kernel-related traits were identified, including both Zm00001d000707 and Zm00001d044139 expressed in the kernel development tissues and stages with unknown functions.DiscussionThese significant SNPs and important haplotypes provide valuable information for developing functional markers for the implementation of marker-assisted selection in breeding. The molecular mechanism of Zm00001d000707 and Zm00001d044139 regulating these kernel-related traits needs to be investigated further.
Human complex mixture analysis by “FD Multi-SNP Mixture Kit”
Authors: Chen Anqi , Li Lun , Zhou Junfei , Li Tiantian , Yuan Chunyan , Peng Hai , Li Chengtao , Zhang Suhua 
Published: September 2024

IntroductionMultiple linked single nucleotide polymorphisms (SNPs) have shown potential in personal identification and mixture detection. However, the limited number of marker and sequencing errors have obstructed accurate DNA typing.MethodsTo develop more candidate loci, the diversity value (D-value) was introduced as a new parameter for screening the novel polymorphic multiple linked-SNP markers, referred to as multi-SNP. In this study, a “FD Multi-SNP Mixture Kit” comprising 567 multi-SNPs was developed for mixture detection. Additionally, a new computational error correction method was applied as a quality control approach for sequencing data.ResultsThe results demonstrated higher typing success rates than the conventional CE typing method. For single-source DNA, approximately 70–80 loci were detected with a DNA input of 0.009765625 ng. More than 65% of the minor alleles were distinguishable at 1 ng DNA with a frequency of 0.5% in 2- to 4-person mixtures.ConclusionThis study offers a polymorphic and high-resolution detection method for DNA genotyping and complex mixture detection, providing an alternative strategy for addressing challenging mixed DNA traces.