bluuebunny/crossref_metadata_2025_split huggingface dataset:
On placental and lactational transfer of IgG‐based therapeutic proteins – Current understanding and knowledge gaps from a clinical pharmacology perspective
Authors: Guinn Daphne , Kratz Katherine , Baisden Kristie , Ridge Sarah , McClymont Sonaly , Fletcher Elimika Pfuma , Johnson Tamara , Wang Yow‐Ming 
Published: October 2024

AbstractMaternal medication use may expose the developing fetus through placental transfer or the infant through lactational transfer. Because pregnant and lactating individuals have been historically excluded from early drug development trials, there is often limited to no human data available to inform pharmacokinetics (PK) and safety in these populations at the time of drug approval. We describe the known mechanisms of placental or lactational transfer of IgG‐based therapeutic proteins and use clinical examples to highlight the potential for fetal or infant exposure during pregnancy and lactation. Placental transfer of IgG‐based therapeutic proteins may result in systemic exposure to the developing fetus. A lactational transfer may be associated with local gastrointestinal (GI) exposure in the infant and may also result in systemic exposure, although data are very limited as proteins have shown instability in the GI tract. Understanding of PK and pharmacodynamic (PD) effects of IgG‐based therapeutic proteins in infants exposed in utero as well as the potential exposure through human milk and its clinical implications is critical for developing treatment strategies for pregnant or lactating individuals. We share the current knowledge gaps and considerations for future evaluations to inform PK, PD, and the safety of IgG‐based therapeutic proteins for safe use during pregnancy and lactation. With the increasing use of IgG‐based therapeutic proteins in treating chronic diseases during pregnancy and lactation, there is a need to improve the quantity and quality of data to inform the safe use in pregnant and lactating individuals.
Measuring the U.S. monetary noise shocks
Authors: Wu Yi‐Hua , Lai Ching‐Chong 
Published: October 2024

AbstractAgents' beliefs regarding future monetary policy changes influence their current decisions. However, these expectations may not always materialize in the future. This study shows that the monetary fundamental shocks (exogenous changes consistent with expectations) stabilize output and inflation, while the noise shocks (biased beliefs that fail to be realized in the future) increase economic fluctuations. Moreover, factors that amplify financial frictions—the spread between the capital return of entrepreneurs and the risk‐free interest rate of a central bank—can increase anticipation effects associated with these two types of monetary policy shocks.
Dentigerous cysts in horses: A retrospective study
Authors: Schläpfer M. , Donati B. , Fürst A. E. , Jackson M. A. 
Published: October 2024

SummaryBackgroundDentigerous cysts are well‐known congenital defects in horses, and the literature on this condition is extensive. Recently, a third type of dentigerous cyst, associated with an exostosis arising from the temporal bone, has been described. Today, computed tomography (CT) is often available and provides detailed information about the exact location and extent of dentigerous cysts, allowing for the description of new findings.Study designThis is a case series outlining the clinical, radiographic and computed tomographic features of dentigerous cysts in seven horses presented to the Equine Clinic at the Vetsuisse Faculty, University of Zurich, Switzerland.ObjectivesThe aim of this case series was to describe the radiographic and computed tomographic findings, and the occurrence of exostoses arising from the temporal bone, in horses with dentigerous cysts.MethodsThe medical records of the Equine Hospital at the University of Zurich were reviewed for horses admitted with dentigerous cysts between 2007 and 2023. Data collected and analysed included patient signalment, clinical history, clinical signs and their duration prior to referral, diagnostic imaging results, treatment and outcomes.ResultsThe most common location for the cysts was the base of the ear, although in one case, the maxillary sinus was involved. Of the seven cases, four were Icelandic horses. CT proved superior to standard radiography for determining the extent and precise location of the cysts, as well as for identifying dental material and exostoses in the temporal region. CT also facilitated detailed surgical planning. All cysts were surgically removed with good long‐term outcomes.Main limitationsOverall, the incidence of dentigerous cysts in horses was low. The relatively high occurrence of dentigerous cysts in Icelandic horses in this study is an interesting finding, though the small sample size calls for further research.ConclusionsTwo of the cases in this series were similar to a recently described variant of a ‘temporal dentigerous cyst associated with an exostosis in the temporal region’ and were closely connected to the bony structure and draining tract.
Surviving academia: Narratives on identity work and intersectionality
Authors: Tekeste Milena , Zakariah Amalina , Azer Evronia , Salahuddin Sarah 
Published: October 2024

AbstractThis paper examines the lived experiences of four early career researchers (ECRs), from various intersecting backgrounds, who pursued their degrees at a prestigious UK university. Bonded through solidarity and care, the authors came together in an online writing group (OWG), which serves as a means of liberation from structural, colonial, and patriarchal oppression. Built upon autoethnographic vignettes, this paper reveals fragile narratives to capture subjective experiences of neglect through the lens of intersectionality and Goffmanian “passing” and “revealing”. Motivated to explore the coping mechanisms of marginalized ECRs, this paper's co‐constructed data collection and co‐generative analysis unpack how a meso‐organization (here, the OWG) allows foreign identities to transcend the constraints of the expected academic professional identity; thus freeing authors from stigma. This paper calls for help and advocates for the urgency of support groups for ECRs as they face issues around finances, political conflicts, and family from pre‐ to post‐COVID‐19 pandemic. Additionally, the research challenges internalized norms of academic productivity and responsibilization and calls for a re‐examination of systemic inequalities. By advocating for collaborative autoethnography and embodied personal storytelling, this study contributes to a richer, more inclusive exploration of intersectionality in academia and emphasizes the need for structural reforms to create more equitable academic environments.
Predictive value of urine microscopy and urine culture in bacteraemic adults without localising urinary features
Authors: Young Nicholas , Beaumont Jenna , Maling Alexandra , Hopkins Christopher 
Published: October 2024

AbstractBackgroundUrine microscopy (UM) and urine culture (UC) are used in bacteraemic patients to identify a urinary focus of infection. However, their positive and negative predictive values (PPV and NPV) in patients without localising urinary features are uncertain.AimsWe aimed to determine the predictive value of UM/UC for diagnosing bacteraemic urinary tract infection (bUTI) in bacteraemic patients without localising urinary features.MethodsA retrospective study of bacteraemic adults was conducted. PPV and NPV of UM/UC for bacteraemic urinary tract infection (bUTI) was determined in two subgroups of patients without localising urinary features: those with an unclear focus of infection, and those with a suspected non‐urinary focus of infection. In those with an unclear focus, univariate analysis for risk factors associated with bUTI was performed.ResultsA total of 871 patients were included. Localising urinary features were absent in 110 of 342 patients (32.2%) with bUTI. In patients with an unclear focus, UM had a PPV of 51.5% and an NPV of 96% for bUTI, and UC had a PPV of 75% and an NPV of 88.6%. In patients with a suspected non‐urinary focus, UM had a PPV of 5.2% and an NPV of 100%, and UC had a PPV of 25% and an NPV of 99.5%. While some risk factors for bUTI in patients with an unclear focus were identified, 22 of 98 patients (22.4%) had bUTI despite no risk factors.ConclusionsbUTI without localising urinary features is common. In bacteraemia of unclear focus, UM/UC has a high NPV for excluding bUTI, although PPV is limited and non‐urinary foci require consideration despite a positive result. UM/UC is low yield in those with a suspected non‐urinary focus of infection.
Unveiling the role of managerial ability in driving productivity, efficiency, and technological change: Insights from the Asian banking sector
Authors: Amirteimoori Alireza , Jradi Samah , Ruggiero John 
Published: October 2024

AbstractIn today's competitive banking industry, the role of capable managers is crucial for the success of banks in facing various challenges and threats. The importance of measuring managerial ability has gained significant attention among researchers. In this study, we focus on assessing the managerial ability of 166 Asian banks from six different countries over the period of 2014–2020. From a rational point of view, productivity growth in banks can be directly related to effective management, as capable managers enhance the bank's productivity. Therefore, our study investigates the relationship between productivity change in banks and managerial ability. Furthermore, we examine the impact of managerial ability on the components of productivity change, specifically efficiency change and technological change. The findings of our study indicate a positive association between managerial ability and both productivity and efficiency change (EC). However, no significant association is observed between managerial ability and technological change.
Obstetric and neonatal outcomes of immune thrombocytopenic purpura in pregnancy and the role of delta hemoglobin index: A case–control study from a tertiary center
Authors: İpek Göksun , Tanaçan Atakan , Demet Ilım , Ağaoğlu Zahid , Yıldız Esra Gülen , Şahin Dilek 
Published: October 2024

AbstractObjectivesTo evaluate the effect of idiopathic thrombocytopenic purpura (ITP) on pregnancies and the role of the delta hemoglobin indices in the evaluation of treatment effectiveness.MethodsThis case–control study was conducted with 23 ITP and 115 low‐risk pregnancies. Obstetric outcomes (fetal growth retardation (FGR), preterm delivery) and neonatal outcomes (weights, APGAR scores, NICU admissions, thrombocytopenia) were recorded. ITP group was subgrouped based on the platelet ratio at the admission for delivery and evaluated the impact of platelet ratios on blood loss amounts at delivery by using delta hemoglobin indices.ResultsEleven patients received treatment during pregnancy. The gestational age at birth and fetal APGAR scores were lower, and the preterm delivery and FGR rates were higher in the ITP group. Four newborns (17.4%) had thrombocytopenia. There were two postpartum hemorrhages. Newborn platelet counts did not correlate with maternal platelet counts. The study showed no difference in delta hemoglobin counts between the ITP and control groups.ConclusionsITP is associated with an increased risk of maternal and fetal complications. The presented study showed by using the delta hemoglobin indices that, hemorrhagic complications could be prevented with appropriate management. Neonatal thrombocytopenia should be considered for all ITP patients.
Comparison of Micro‐CT and Morphometric Outcomes in a Modified Experimental Rat Model of Periodontitis
Authors: Bueno Jaime , Martínez María , Ambrosio Nagore , del Rosal Juan , Robledo‐Montaña Javier , Gamonal Juan D. , Virto Leire , Montero Eduardo , Martín‐Hernández David , Marín María José , Herrera David , Sanz Mariano , García‐Bueno Borja , Leza Juan C. , Haugen Håvard J. , Figuero Elena 
Published: October 2024

ABSTRACTAimTo assess the correlation between micro‐computed tomography (micro‐CT) and linear morphometric measurements in terms of mandibular bone levels in a modified experimental periodontitis model in rodents to study the mechanisms of association between periodontal destruction and neuroinflammation.MethodsThe proposed in vivo experimental periodontitis model involves the administration of oral rinses with Porphyromonas gingivalis and Fusobacterium nucleatum, four times per week during 4, 8 or 12 weeks, in 24 male Wistar Hannover rats (180 g, 5 weeks old). After euthanasia, hemi‐mandibles were collected. One hemi‐mandible was analysed using morphometry, while the other was assessed with micro‐CT. Linear measurements were taken at the buccal aspect and furcation level for both techniques, and volumetric measurements were also obtained with micro‐CT. Passing–Bablok regression analysis was used to compare the results of both techniques, with morphometric measurements serving as the reference. Moreover, Lin's Concordance correlation coefficient was calculated to assess the level of agreement. Periodontal clinical variables with neuroinflammatory parameters from the frontal cortex were used to evaluate the association between the resulting condition and neuroinflammation.ResultsTwenty‐one out of the initial 24 rats were analysed. The micro‐CT linear measurements demonstrated high concordance values with the linear morphometric measurements at the buccal surfaces of the roots in molars (r = 0.714) but not at the furcation area (r = 0.052). At 12 weeks, there was a significant impact on neuroinflammation with significant decreases in iNOS levels and p‐mTOR levels at 4 and 8 weeks.ConclusionThe proposed in vivo experimental periodontitis model demonstrated a high degree of correlation between morphometric and micro‐CT measurements in buccal areas but not at the furcation level. Concomitantly, there was a significant temporary modulation of the neuroinflammatory response.
Caffeic acid: A game changer in pine wood nematode overwintering survival
Authors: Wang Jianan , Chen Qiaoli , Xu Bihe , Yu Qi , Shen Yulan , Wu Hao , Jiang Shengwei , Zhou Yantao , Li Danlei , Wang Feng 
Published: October 2024

AbstractFollowing the invasion by the pine wood nematode (PWN) into north‐east China, a notable disparity in susceptibility was observed among Pinaceae species. Larix olgensis exhibited marked resilience and suffered minimal fatalities, while Pinus koraiensis experienced significant mortality due to PWN infection. Our research demonstrated that the PWNs in L. olgensis showed a 13.43% reduction in lipid content compared to P. koraiensis (p < 0.05), which was attributable to the accumulation of caffeic acid in L. olgensis. This reduction in lipid content was correlated with a decreased overwintering survival of PWNs. The diminished lipid reserves were associated with substantial stunting in PWNs, including reduced body length and maximum body width. The result suggests that lower lipid content is a major factor contributing to the lower overwintering survival rate of PWNs in L. olgensis induced by caffeic acid. Through verification tests, we concluded that the minimal fatalities observed in L. olgensis could be attributed to the reduced overwintering survival of PWNs, a consequence of caffeic acid‐induced stunting. This study provides valuable insights into PWN–host interactions and suggests that targeting caffeic acid biosynthesis pathways could be a potential strategy for managing PWN in forest ecosystems.
The effect of end‐of‐life care awareness education on the knowledge, attitudes and behaviours of intensive care nurses: A randomized controlled trial
Authors: Demir Fırat , Polat Dunya Cansu , Özkan İlknur 
Published: October 2024

AbstractBackgroundEducation in end‐of‐life care (EoLC) is essential for improving the knowledge, attitudes and behaviours of intensive care nurses.AimThis study aimed to evaluate the effect of online awareness education, based on the End‐of‐Life Nursing Education Consortium, on the knowledge levels, attitudes and behaviours of intensive care nurses.Study designThis single‐centre randomized controlled study. This study was performed in a tertiary intensive care unit in a university‐affiliated hospital. Seventy‐six intensive care nurses were selected and equally randomized. In the education, the group was given an EoLC awareness education programme on an online platform as 40–60‐min sessions once a week for 4 weeks. The descriptive Information Form, EoLC Knowledge Test and the Nurses' Attitudes and Behaviours towards the EoLC Scale were used. In the study, intensive care nurses' knowledge, attitude and behaviour levels towards EoLC were evaluated before and after 4 weeks (±3 days) following the education.ResultsWhen the mean post‐education scores of the nurses in the education group were compared with the control group, it was found that their mean scores on the EoLC Knowledge Test (p = .001, Cohen's d = 1.354, 95% CI = 3.240–6.549), the attitude sub‐dimension (p = .001, Cohen's d = 1.520, 95% CI = 4.510–7.858), the behaviour sub‐dimension (p = .001, Cohen's d = 1.425, 95% CI = 3.206–6.214) and the total attitude and behaviour (p = .001, Cohen's d = 1.927, 95% CI = 8.408–13.643) were statistically significantly higher than those of the control group.ConclusionThis study showed that EoLC awareness education positively affected nurses' knowledge, attitudes and behaviours. Accordingly, planning EoLC awareness education online at regular intervals may be recommended for intensive care nurses.Relevance to Clinical PracticeIntensive care nurses may be given online EoLC awareness education to positively affect their knowledge, attitudes and behaviours about EoLC. Online EoLC education can be effective in terms of reaching a large number of nurses, time and cost.
Immunohistochemical Evaluation of p300, H2AacK5 and H3AcK27 in Odontogenic Cysts and Tumors
Authors: Carvalho Luciane De Jesus , Guimarães Douglas Magno , Souza Alann Thaffarell Portilho , Balbinot Karolyny Martins , Kataoka Maria Sueli da Silva , Alves Junior Sérgio de Melo , Nunes Fabio Daumas , da Silva Marcos José Custódio Neto , Pinheiro João de Jesus Viana 
Published: October 2024

ABSTRACTThe acetylation of histones H2A on lysine 5 (H2AacK5) and H3 on lysine 27 (H3AcK27) modulate several cellular mechanisms through the p300 enzyme in pathological lesions; however, their role in odontogenic lesions has not been addressed. This study aims to evaluate the immunoexpression of p300, H2AacK5, and H3AcK27 in samples of ameloblastoma (AMB) (n = 30), odontogenic keratocyst (OK) (n = 15), adenomatoid odontogenic tumor (AOT) (n = 10), odontogenic fibroma (OF) (n = 8), calcifying odontogenic cyst (COC) (n = 8), odontogenic myxoma (MIX) (n = 10), and ameloblastic fibroma (AF) (n = 06). The percentage of p300‐positive cells was higher in AOT and decreased in COC, OK, AMB, AF, OF, and MIX. H2AacK5‐positive cells were higher in AF and decreased in AOT, COC, OK, OF, AMB, and MIX, whereas H3acK27‐positive cells were higher in AOT and decreased in COC, OK, AF, OF, AMB, and MIX. The expression of these proteins was higher in nonaggressive lesions in comparison to aggressive lesions. There was a positive correlation between p300 and H2AacK5, and H3acK27 in AMB, MIX, and OF, whereas there was a positive correlation between p300 and H2AacK5 in AOT and COC. The histone acetylation may be involved in the biological behavior of these lesions, which could be used to improve their diagnosis and treatment.
Shared anthropology of the Middle East: Essays on media in honor of Faye Ginsburg
Authors: Hamdy Sherine , Bishara Amahl 
Published: October 2024

AbstractThe articles in this special issue are the outcome of the panel: “Papers in Honor of Faye Ginsburg: Visual and Media Anthropology in the Middle East,” which was held virtually for the American Anthropological Association Annual Meetings of November 2021. The reach of Ginsburg's work as well as her mentorship through the creation of NYU's Graduate Program in Culture & Media has shaped the ethnography of media and visual anthropology across a diversity of geographic regions. In this particular issue, we bring together scholars of SWANA (Southwest Asia and North Africa, a term that more broadly encompasses what is often referred to as the Middle East) whose projects are deeply influenced by Ginsburg's scholarship on shared anthropology, collaborative media practices and cultural activism. This introduction includes excerpts from a conversation with Ginsburg.
Control Strategy Optimization for Electrostatic Precipitator System of Coal-Fired Power Plant Integrated With the Waste Heat Recovery System During Load Cycling Dynamic Processes
Authors: Gao Wei , Liu Ming , Zhao Yongliang , Wang Chaoyang , Yan Junjie 
Published: October 2024

Abstract
Coal-fired power plants will undertake more and more peak shaving and frequency regulation tasks to accommodate high penetration of fluctuating renewables. As a result, they often operate in load cycling dynamic processes, and the emissions of particulate matter (PM) are unavoidably affected by operation mode. Electrostatic precipitator (ESP) is widely applied in coal-fired power plants for collecting PM from flue gas, and the wet flue gas desulfurization (WFGD) system also removes PM while achieving efficient desulfurization. Because the flue gas temperature is an important factor affecting the PM removal efficiency, the regulation of the waste heat recovery system integrated within coal-fired power plants, which will influence the temperature of flue gas to ESP, will affect the operation of ESP. To achieve efficient PM removal, the dynamic characteristics and control strategies for the electrostatic precipitator system during load cycling dynamic processes should be further studied. In this study, the dynamic model of ESP was developed based on the Deutsch’s model, and the dynamic model of PM removal in WFGD system was developed with neural networks. These models were coupled with the dynamic model of a coal-fired power plant integrated with the waste heat recovery system. Then, changes in PM emissions were dynamically simulated during the load cycling processes. Dynamic characteristics of PM emissions influenced by the waste heat recovery system and WFGD system during the transient processes were obtained. Furthermore, an optimization control strategy for the electrostatic precipitator system was proposed based on the dynamic characteristics of PM emissions. When the proposed control strategy was adopted, the transient overshoot of PM emissions during the loading up processes could be avoided, and the power consumption of electrostatic precipitator system could be reduced considerably during the loading down processes.