bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing impulsivity in individuals with methamphetamine and methcathinone use disorders
Authors: Yin Jie , Cheng Xinyu , Zhou Chendi , Xu Lin , Yang Bo , Yuan Ti-Fei 
Published: October 2024

BackgroundIndividuals with substance use disorder (SUD) are characterized by loss of control in drug use, such as increased impulsivity. Methamphetamine and methcathinone are psychostimulants, the use of which is accompanied by a high level of impulsivity. Whether individuals with methamphetamine use disorder (MUD) and methcathinone use disorder (MCUD) differ in different aspects of impulsivity is unclear.MethodsWe investigated impulsivity traits and behaviors in individuals with MUD and MCUD. The Barratt Impulsiveness Scale (BIS), Sensation Seeking Scale (SSS), and delay discounting task (DDT) were assessed in individuals with MUD and MCUD and in healthy controls (HCs); then, we performed network-based analysis and computational modeling to understand the potential differences among the three groups.ResultsMUD subjects scored higher than MCUD subjects in terms of motor impulsivity, nonplanning impulsivity, and total BIS scores. The network analysis revealed that there were no significant differences between MUD and MCUD subjects in any centrality indices. The discount rate of MUD and MCUD subjects was significantly greater than that of HCs, whereas there was no difference in the discount rate between the two addiction groups.ConclusionsThese findings suggest that MUD and MCUD participants differ in impulsivity traits but not in impulsive behaviors, implying that impulsive traits and behaviors represent different aspects of impulsivity.
Hypnotherapy modulating early and late event-related potentials components of face processing in social anxiety
Authors: Zhang Han , Xue Xinrong , Wen Jialin , Li Yongyi , Fan Chuan , Ma Lijun , Wang Huixue , Zhang Mi , Zhang Shuyu , Hu Die , Wang Kai , Li Xiaoming 
Published: October 2024

BackgroundHypnotherapy has a potential role in modulating attention bias to treat social anxiety disorder (SAD). This study aimed to verify whether hypnotherapy can reduce social anxiety by changing attentional bias. The primary objective of our study is to explore the influence of hypnosis on various aspects of attention processes, specifically focusing on how it affects attention bias and social anxiety.MethodsThis study included 69 participants with SAD who were assigned to three groups based on their scores on the Liebowitz Social Anxiety Scale (LSAS). The experimental group (n = 23) received a hypnosis treatment once a week, for a total of six sessions, while the control group (n = 23) and the baseline group (n = 23) did not receive any treatment. To evaluate whether hypnosis could alleviate SAD and attention bias towards threatening stimuli, we employed questionnaires and an odd-one-out task accompanied by electroencephalography (EEG) recordings.ResultsUnder the attention sensitivity conditions, the experimental group exhibited a reduced N170 and LPP at the posttest stage, and a similar N170 and LPP reduction under the attention disengagement conditions. Notably, the symptom improvements were positively correlated with the reduction in N170 and LPP amplitude across conditions.ConclusionHypnosis treatment modulates the early face processing and late emotional evaluation of threat-related stimuli in SAD patients. These findings suggest that N170 and LPP are important biomarkers for the treatment of SAD.
Qualitative analysis of emotional distress in burns, plastic and reconstructive surgery patients from the perspectives of cognitive and metacognitive models
Authors: Taylor-Bennett Joseph , Capobianco Lora , Wisely Julie , Wells Adrian 
Published: October 2024

IntroductionBurns and other injuries requiring plastic and/or reconstructive surgery (BPRS) are lifechanging, often unexpected, and increase the risk of psychiatric morbidity. There are no published studies we are aware of that explores the applicability of psychological models to BPRS patients. Cognitive behavioural therapy (CBT) is the benchmark treatment in mental health but may be less effective in physical health settings. Metacognitive therapy (MCT)can be more effective than CBT in mental health settings and shows promise in reducing anxiety and depression symptoms in people with cancer and cardiac disease. The present study explored the psychological experiences (feelings, thoughts, and coping strategies) of BPRS patients, and whether the concepts underpinning cognitive and metacognitive models can be elicited from these accounts.MethodSemi structured interviews were conducted with 11 patients recruited from a BPRS psychology service. Data was analysed using Thematic Analysis. Patients described a range of emotions including low mood, anxiety, anger, guilt, loss, and negative thinking.ResultsFrom the perspective of the cognitive model, there were examples of each of 10 pre-specified distorted thinking types (cognitive distortions), and patient talk seemed to fit problem-specific cognitive models. From the perspective of the metacognitive model, all patients described the “cognitive attentional syndrome,” i.e., how they engaged in repetitive negative thinking (worry, rumination) and thought-focused regulation strategies. Patient talk also demonstrated both positive and negative metacognitive beliefs.ConclusionThe implications of applying the findings from each model to clinical practice are discussed. The metacognitive model may offer benefits in clinical practice that should be investigated further.
Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature
Authors: Halliday Amanda R. , Vucic Samuel N. , Georges Brianna , LaRoche Madison , Mendoza Pardo María Alejandra , Swiggard Liam O. , McDonald Kaylee , Olofsson Michelle , Menon Sahit N. , Francis Sunday M. , Oberman Lindsay M. , White Tonya , van der Velpen Isabelle F. 
Published: October 2024

BackgroundA growing body of literature classifies autism spectrum disorder (ASD) as a heterogeneous, complex neurodevelopmental disorder that often is identified prior to three years of age. We aim to provide a narrative review of key structural and functional properties that differentiate the neuroimaging profile of autistic youth from their typically developing (TD) peers across different neuroimaging modalities.MethodsRelevant studies were identified by searching for key terms in PubMed, with the most recent search conducted on September 1, 2023. Original research papers were included if they applied at least one of seven neuroimaging modalities (structural MRI, functional MRI, DTI, MRS, fNIRS, MEG, EEG) to compare autistic children or those with a family history of ASD to TD youth or those without ASD family history; included only participants &lt;18 years; and were published from 2013 to 2023.ResultsIn total, 172 papers were considered for qualitative synthesis. When comparing ASD to TD groups, structural MRI-based papers (n = 26) indicated larger subcortical gray matter volume in ASD groups. DTI-based papers (n = 14) reported higher mean and radial diffusivity in ASD participants. Functional MRI-based papers (n = 41) reported a substantial number of between-network functional connectivity findings in both directions. MRS-based papers (n = 19) demonstrated higher metabolite markers of excitatory neurotransmission and lower inhibitory markers in ASD groups. fNIRS-based papers (n = 20) reported lower oxygenated hemoglobin signals in ASD. Converging findings in MEG- (n = 20) and EEG-based (n = 32) papers indicated lower event-related potential and field amplitudes in ASD groups. Findings in the anterior cingulate cortex, insula, prefrontal cortex, amygdala, thalamus, cerebellum, corpus callosum, and default mode network appeared numerous times across modalities and provided opportunities for multimodal qualitative analysis.ConclusionsComparing across neuroimaging modalities, we found significant differences between the ASD and TD neuroimaging profile in addition to substantial heterogeneity. Inconsistent results are frequently seen within imaging modalities, comparable study populations and research designs. Still, converging patterns across imaging modalities support various existing theories on ASD.
Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
Authors: Ciapponi Agustín , Palermo María Carolina , Sandoval María Macarena , Baumeister Elsa , Ruvinsky Silvina , Ulloa-Gutierrez Rolando , Stegelmann Katharina , Ruesjas Sofía Ardiles , Cantos Joaquín , LaRotta Jorge , de Almeida Rodrigo Sini , Bardach Ariel 
Published: October 2024

BackgroundRespiratory Syncytial Virus (RSV) is a common cause of lower respiratory tract infections (LRTI) and hospitalization worldwide. The impact of RSV in Latin America and the Caribbean (LAC) including expensive treatment options, such as palivizumab, have been extensively discussed. However, publications on the impact of RSV disease burden in the region are scarce. This systematic review aimed to determine the incidence and prevalence of RSV in LAC by age and RSV subtype.MethodsWe conducted a systematic review following Cochrane methods to evaluate the disease burden of RSV in LAC countries. We searched studies from January 2012 to January 2023 in literature databases and grey literature without language restrictions. We included guidelines, observational, economic, and surveillance studies from LAC countries. Pairs of reviewers independently selected, and extracted data from included studies. The risk of bias was assessed using the Study Quality Assessment Tools (NHLBI) and AGREE-II. We performed proportion meta-analyses using methods to stabilize the variance. The protocol was registered in PROSPERO (CRD42023393731).ResultsWe included 156 studies, mainly from Brazil (25%), Colombia (14.5%), and Argentina (13.8%), as well as four clinical practice guidelines. Most studies were cross-sectional (76.9%) and were classified as low risk of bias (52.6%). The majority included inpatients (85.6%), pediatric (73.7%), and normal-risk patients (67.1%). The highest pooled prevalence was estimated in patients &lt;1 year old (58%), with type A and B prevalence of 52 and 34%, respectively. The RSV-LRTI incidence was 15/100 symptomatic infants aged &lt;2 years old, and the ICU admission was 42%. The RSV-LRTI lethality was 0.6, 3% in patients aged &lt;2 and 0–5 years old, respectively, and 23% among &gt;65 years old high-risk patients. The identified guidelines lack methodological rigor and have limitations in their applicability. The seasonality was more evident in South America than in Central America and The Caribbean, with a clear gap during the pandemic.ConclusionThis is the most exhaustive and updated body of evidence describing a significant burden of RSV in LAC, particularly at the extremes of life, and its seasonality patterns. Our findings could contribute could contribute facilitating effective prevention and treatment strategies for this significant public health problem.Systematic review registrationPROSPERO CRD UK (registration number: CRD42023393731).
Major air pollution and climate policies in NYC and trends in NYC air quality 1998–2021
Authors: Lau Kathleen , Guo Jia , Miao Yuqi , Ross Zev , Riley Kylie W. , Wang Shuang , Herbstman Julie , Perera Frederica 
Published: October 2024

IntroductionAir pollution poses serious health risks to humans, with particular harm to children.ObjectivesTo address the gap in understanding the efficacy of policies to reduce exposure to air pollution, we sought to assess the temporal relationship between the enactment of major air pollution and climate policies in NYC and trends in air quality during the period 1998–2021. We used previously available data from citywide monitoring and new data from the Columbia Center for Children’s Environmental Health (CCCEH) longitudinal cohort studies of mothers and children living in communities in Northern Manhattan and the South Bronx.MethodsWe utilized publicly available citywide air monitoring data for particulate matter (PM2.5) and nitrogen dioxide (NO2) from 2009 to 2021 from the New York City Community Air Survey (NYCCAS) database and CCCEH cohort data on residential exposure to PM2.5 and NO2 and personal exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancies occurring from 1998–2016 and 1998–2021, respectively. We compared annual and overall reductions in PM2.5 and NO2 citywide and reductions in PAH concentrations in the cohort studies.ResultsAs previously reported, annual average concentrations of pollutants in NYC dropped significantly over time. Between 1998 and 2021, PM2.5 and NO2 concentrations were reduced citywide by 37 and 31%, respectively. In our CCCEH cohorts, between 1998 and 2016, the annual average PM2.5 and NO2 concentrations also decreased significantly by 51 and 48%, respectively. Between 1998 and 2020, PAH concentrations decreased significantly by 66%.Discussion/conclusionWhile it is not possible to link improved air quality to a single policy, our analysis provides evidence of a cumulative beneficial effect of clean air and climate policies enacted between 1998 and 2021 both city-wide and in our cohorts residing in communities that have been disproportionately affected by air pollution. There are important implications for health benefits, particularly for children, who are known to be especially vulnerable to these exposures. The results support further environmental and social policy changes to prevent the serious health impacts of air pollution from fossil fuel emissions.
Evaluation of caries risk assessment practices among dental practitioners in Guangzhou, China: a cross-sectional study
Authors: Nie Ermin , Jiang Rui , Islam Rafiqul , Li Xiang , Yu Jiali 
Published: October 2024

IntroductionThis cross-sectional study aimed to investigate dental practitioners’ knowledge and practices regarding Caries risk assessment (CRA) in routine clinical practice in Guangzhou, China.MethodsAn online questionnaire was disseminated to dental practitioners to gather socio-demographic information, factors associated with CRA, the implementation of preventive treatment, and the level of awareness regarding personalized preventive treatment in relation to CRA. Statistical analyses included descriptive statistics, Chi-square tests, ANOVA, MANCOVA, linear regression, and scatter plots.Results and discussionOut of the 695 dental practitioners who were contacted, 206 dentists participated in the online survey. However, out of the total number of dentists, 198 were successfully recruited, while the remaining 8 dentists had incomplete data in their questionnaires. 92.4% of dentists provided in-office fluoride treatments, and 73.2% held a strong belief in the correlation between current oral hygiene and tooth cavities. 23.7% of dentists evaluated caries risk on an individual basis, and a significant 41.9% never utilized a particular type of CRA. 53.5% of dentists recommended non-prescription fluoride rinses, whereas 51% advocated prescription fluoride treatments. Significant statistical relationships were found between the use of in-office fluoride and the effectiveness of restorative treatment (P &lt; 0.05). Additionally, a significant association was discovered between the use of a specific form for CRA and the kind of dental school (P &lt; 0.05). The study suggests that a significant number of dental practitioners in Guangzhou, China, do not utilize dedicated assessment forms for CRA in their routine professional activities. These findings highlight the im-portance of encouraging dentists to utilize CRA systems to effectively identify patients who are at risk of acquiring dental caries.
Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants
Authors: Burny Claire , Potočnjak Mia , Hestermann Annika , Gartemann Sophie , Hollmann Michael , Schifferdecker-Hoch Frank , Markanovic Nina , Di Sanzo Simone , Günsel Michael , Solis-Mezarino Victor , Voelker-Albert Moritz 
Published: October 2024

BackgroundWith its high and increasing lifetime prevalence, back pain represents a contemporary challenge for patients and healthcare providers. Monitored exercise therapy is a commonly prescribed treatment to relieve pain and functional limitations. However, the benefits of exercise are often gradual, subtle, and evaluated by subjective self-reported scores. Back pain pathogenesis is interlinked with epigenetically mediated processes that modify gene expression without altering the DNA sequence. Therefore, we hypothesize that therapy effects can be objectively evaluated by measurable epigenetic histone posttranslational modifications and proteome expression. Because epigenetic modifications are dynamic and responsive to environmental exposure, lifestyle choices—such as physical activity—can alter epigenetic profiles, subsequent gene expression, and health traits. Instead of invasive sampling (e.g., muscle biopsy), we collect easily accessible buccal swabs and plasma. The plasma proteome provides a systemic understanding of a person's current health state and is an ideal snapshot of downstream, epigenetically regulated, changes upon therapy. This study investigates how molecular profiles evolve in response to standardized sport therapy and non-controlled lifestyle choices.ResultsWe report that the therapy improves agility, attenuates back pain, and triggers healthier habits. We find that a subset of participants' histone methylation and acetylation profiles cluster samples according to their therapy status, before or after therapy. Integrating epigenetic reprogramming of both buccal cells and peripheral blood mononuclear cells (PBMCs) reveals that these concomitant changes are concordant with higher levels of self-rated back pain improvement and agility gain. Additionally, epigenetic changes correlate with changes in immune response plasma factors, reflecting their comparable ability to rate therapy effects at the molecular level. We also performed an exploratory analysis to confirm the usability of molecular profiles in (1) mapping lifestyle choices and (2) evaluating the distance of a given participant to an optimal health state.ConclusionThis pre-post cohort study highlights the potential of integrated molecular profiles to score therapy efficiency. Our findings reflect the complex interplay of an individual's background and lifestyle upon therapeutic exposure. Future studies are needed to provide mechanistic insights into back pain pathogenesis and lifestyle-based epigenetic reprogramming upon sport therapy intervention to maintain therapeutic effects in the long run.
Rural household resilience to food insecurity in Mekiet district, Ethiopia
Authors: Dessie Tadsual Asfaw , Demsie Birhan Sisay 
Published: October 2024

IntroductionFood insecurity remains a global issue and a top national priority in Ethiopia. However, it continues to pose a serious challenge in rural areas. Therefore, this study investigated household resilience to food insecurity among rural residents in Mekiet district.MethodsA cross-sectional research design was used, focusing on two agroecological zones of Mekiet district—lowland and midland—involving 228 respondents. The study employed both quantitative and qualitative approaches. Multistage sampling techniques were employed to select the sample households, and factor analysis was employed to analyze the data.Results and discussionThe results from the factor analysis using the TANGO approach showed that the latent variables of absorptive and adaptive capacities had factor loadings of 0.98 and 0.79, respectively. On the other hand, transformative capacity showed a negative loading (−0.78), with all variables being statistically significant. The mean household resilience capacity index was 0.51. The variables of absorptive and adaptive capacities were positively associated with household resilience capacity, while transformative capacity exhibited a strong negative association. All factor loadings were significant, exceeding the recommended absolute value of 0.364 for sample sizes of 200 or more. Additionally, these variables were also highly correlated with resilience capacity. The study recommends that resilience programs be implemented at district, community, and household levels to enhance resilience to food insecurity.
Evaluating robotic assistance on the learning curve and efficiency of mandibular angle ostectomy: an animal model study
Authors: Han Wenqing , Yan Yingjie , Sun Mengzhe , Zhang Ziwei , Lin Li , Zhang Yan , Chai Gang 
Published: October 2024

IntroductionThis study evaluated the efficacy and learning curve of a maxillofacial surgical robotic system (MSRS) guided by electromagnetic navigation for mandibular angle ostectomy (MAO), compared to traditional surgical methods.MethodsThe study utilized a controlled experiment involving thirty rabbits, paired divided into experimental and control groups. The experimental group underwent MAO using the MSRS, while the control group was treated with conventional surgical techniques. The surgeons performing the procedures were inexperienced in robotic surgery and MAO to assess the learning curve and the impact of robotic assistance. Key parameters measured included the accuracy of ostectomy, setup time, and ostectomy efficiency, with data analyzed through a paired-t test to compare the performance between the two groups.ResultsThe study indicated a significant reduction in ostectomy time for the experimental group, with improved accuracy and efficiency in ostectomy. The study found that robotic assistance could decrease the risk of complications and enhance surgical outcomes. It also highlighted the presence of an initial learning curve when adopting new robotic technologies, which could be mitigated through adequate training and simulation practices.DiscussionUsing MSRS for MAO could lead to faster early learning curves and increased ostectomy efficiency compared to traditional surgical methods. It demonstrated the potential benefits of integrating robotic systems into craniofacial surgery, suggesting a promising direction for future surgical practices.
Experimental Study on Ice Shedding Behaviors for Aero-Engine Fan Blade Icing during Ground Idle
Authors: Wang Liping , Yang Kun , Yu Fang , Wang Fuxin 
Published: October 2024

Fan blade icing can affect efficiency and aerodynamic stability, and the shed ice may be sucked into the core of the engine, causing adverse effects or even damage to the compressor components. Ice accretion and shedding are among the key issues in engine design and tests. But they have not been clearly understood. In this work, ice shedding from rotating aero-engine fan blades during continuous icing is experimentally investigated under the relevant airworthiness requirements. The phenomena of icing and ice shedding under different ambient temperatures and engine speeds are recorded to obtain the ice-shedding time and the characteristic length of the residual ice. Force analysis is used to understand the corresponding behavior. The degree of ice-shedding balance Db is defined to explore the symmetry of ice shedding. The results show that the shedding time is significantly affected by the rotational speed, and the characteristic length will first shorten and then grow as the ambient temperature decreases. When the ice shedding is completed instantaneously, Db will show a violent shock. There is a critical ambient temperature, below which the ice accretion will worsen significantly as temperature decreases. For aero-engine fan blade icing tests during ground idle, the critical ambient temperature ranges from −5 ∘C to −9 ∘C. In order for the ice to shed faster, the engine speed has to reach a threshold. This study can shed light on the preliminary characteristics of ice shedding from rotating components and provide guidance and a data basis for the numerical simulation of fan blade icing and the design of an aero-engine.