bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bivalirudin versus heparin in patients undergoing percutaneous transcatheter aortic valve interventions: A systematic review and meta‐analysis
Authors: Villablanca Pedro A. , Al‐Bawardy Rasha , Mohananey Divyanshu , Maraboto Carola , Weinreich Michael , Gupta Tanush , Briceno David F. , Ramakrishna Harish 
Published: August 2017

BackgroundBivalirudin may be an effective anticoagulation alternative to heparin as anticoagulant agent in percutaneous transcatheter aortic valve interventions (PAVI). We aimed to compare safety and efficacy of bivalirudin versus heparin as the procedural anticoagulant agent in patients undergoing PAVI.MethodsWe conducted an electronic database search of all published data. The primary efficacy endpoints were all‐cause mortality, cardiovascular mortality, myocardial infarction, and stroke. Safety endpoints include major and life‐threatening bleed according to VARC and BARC bleeding, blood transfusion, vascular complications, and acute kidney injury. Odds ratios (OR) and 95% confidence intervals (CI) computed using the Mantel‐Haenszel method.ResultsThree studies (n = 1690 patients) were included, one randomized trial and two observational studies. There was a significant difference favoring bivalirudin over heparin for myocardial infarction (OR 0.41, 95%CI 0.20‐0.87). There was no significant difference in all‐cause mortality at 30 days (OR 0.97, 95%CI 0.62‐1.52), cardiovascular mortality (OR 1.03, 95%CI 0.52‐2.05), stroke (OR 1.23, 95%CI 0.62‐2.46), vascular complications (OR 0.96, 95%CI 0.70‐1.32), acute kidney injury (OR 1.03, 95%CI 0.53‐2.00), blood transfusion (OR 0.67, 95% CI 0.45‐1.01), major and life‐threatening bleed (OR 0.74, 95%CI 0.37‐1.49), and BARC bleeding (OR 0.52, 95%CI 0.23‐1.18).ConclusionsIn patient undergoing aortic valve interventions, no difference was seen between the use of bivalirudin and heparin as the procedural anticoagulant agent, except for a significant lower myocardial infarction events when bivalirudin was used. Further large randomized trials are needed to confirm current results.
Automatic affective responses towards the bed in patients with primary insomnia: evidence for a negativity bias
Authors: Koranyi Nicolas , Meinhard Marie , Bublak Peter , Witte Otto W. , Rupprecht Sven 
Published: August 2017

SummaryRuminating about sleep problems and negatively valenced thinking play a key role in the maintenance of sleep complaints in patients with insomnia. Based on associative learning principles, we hypothesized that repeated co‐occurrence of negative thoughts (unconditioned stimulus) and the bedroom environment (conditioned stimulus) results in automatic negative affective responses towards the bed (conditioned response). Twenty‐two insomniacs and 22 good sleepers performed a Single‐Target Implicit Association Test measuring the strength of automatically triggered affective responses towards the bed. Results revealed a significant group difference, indicating a stronger negative affective response towards the bed in patients with insomnia. No correlations were found between the strength of negative affective responses towards the bed and subjective measures of sleep quality. As it might increase the stress experience further during bedtime, automatic negative responses towards the bed are likely to represent an additional factor accounting for the development and maintenance of sleep disorders and represent a potential target for therapeutic interventions.
Gene copy number variations in adaptive evolution: The genomic distribution of gene copy number variations revealed by genetic mapping and their adaptive role in an undomesticated species, white spruce (Picea glauca)
Authors: Prunier Julien , Caron Sébastien , Lamothe Manuel , Blais Sylvie , Bousquet Jean , Isabel Nathalie , MacKay John 
Published: August 2017

AbstractGene copy number variation (CNV) has been associated with phenotypic variability in animals and plants, but a genomewide understanding of their impacts on phenotypes is largely restricted to human and agricultural systems. As such, CNVs have rarely been considered in investigations of the genomic architecture of adaptation in wild species. Here, we report on the genetic mapping of gene CNVs in white spruce, which lacks a contiguous assembly of its large genome (~20 Gb), and their relationships with adaptive phenotypic variation. We detected 3,911 gene CNVs including de novo structural variations using comparative genome hybridization on arrays (aCGH) in a large progeny set. We inferred the heterozygosity at CNV loci within parents by comparing haploid and diploid tissues and genetically mapped 82 gene CNVs. Our analysis showed that CNVs were distributed over 10 linkage groups and identified four CNV hotspots that we predict to occur in other species of the Pinaceae. Significant relationships were found between 29 of the gene CNVs and adaptive traits based on regression analyses with timings of bud set and bud flush, and height growth, suggesting a role for CNVs in climate adaptation. The importance of CNVs in adaptive evolution of white spruce was also indicated by functional gene annotations and the clustering of 31% of the mapped adaptive gene CNVs in CNV hotspots. Taken together, these results illustrate the feasibility of studying CNVs in undomesticated species and represent a major step towards a better understanding of the roles of CNVs in adaptive evolution.
Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome
Authors: Davydov D. M. , Naliboff B. , Shahabi L. , Shapiro D. 
Published: August 2017

AbstractBackgroundObjective measures of pain severity remain ill defined, although its accurate measurement is critical. Reciprocal baroreflex mechanisms of blood pressure (BP) control were found to impact differently on pain regulation, and thus their asymmetry was hypothesized to also connect to chronic pain duration and severity.MethodsSeventy‐eight female patients with irritable bowel syndrome (IBS) and 27 healthy women were assessed for IBS severity and chronicity, negative affect, and various measures of resting autonomic function including BP, heart rate and its variability (HRV), baroreceptor‐sensitivity to activations and inhibitions, gains of brady‐ and tachy‐cardiac baro‐responses, gains of BP falls/rises, and BP start points for these spontaneous baroreflexes.Key ResultsIBS directly and indirectly (through increased negative affect) was associated with asymmetry between baroreceptor activations/inhibitions compared to symmetrical baroreflex reciprocity in the healthy women. In the IBS group, independently of specific IBS symptoms, pain chronicity was associated with (i) decreased BP falls coupled with either (a) decreased tachycardia associated with lower disease severity (earlier “pain resilience” mechanism), or (b) decreased bradycardia associated with higher disease severity (later “pain decompensation” mechanism), or (ii) increased BP start point for baroreceptor activations coupled with either (a) BP increase (delayed “pain adaptation” mechanism) or (b) affect‐related HRV decrease (delayed “pain aggravation” mechanism).Conclusion and InferencesWe anticipate the findings to be a starting point for validating these autonomic metrics of pain suffering and pain coping mechanisms in other chronic pain syndromes to suggest them as biomarkers of its severity and duration for profiling and correct management of chronic pain patients.
A case of congenital lipomatous overgrowth, vascular malformations, epidermal nevi, spinal/skeletal anomalies and/or scoliosis syndrome with lipoatrophy as an important clinical manifestation
Authors: Schreiber Ariane , Grenier Pierre‐Olivier , Auger Isabelle 
Published: August 2017

AbstractCongenital lipomatous overgrowth, vascular malformations, epidermal nevi, spinal/skeletal anomalies and/or scoliosis syndrome is a PIK3CA‐related overgrowth spectrum presenting with congenital, asymmetric, disproportionate overgrowth associated with dysregulated adipose tissue, enlarged bony structures, and mixed primarily truncal vascular malformations. We present this case to raise awareness that very thin body habitus (lipoatrophy) contrasting with areas of overgrowth can be an important clinical feature of this syndrome and, if not recognized, can lead to unnecessary investigations.
Validity of Single Question for Screening Intimate Partner Violence among Urban Latina Women
Authors: Kim Young‐Ju , Montano Nilda Peragallo 
Published: August 2017

AbstractObjectiveThe purpose of this study was to test the validity of a single violence question compared with revised Conflict Tactics Scales (CTS2) as an initial tool which can be easily used in community‐based health care settings to detect IPV in Latina women.Design and SampleThe study was conducted using secondary analyses of the baseline data from a culturally tailored HIV risk prevention project SEPA. A total of 657 Mexican and Puerto‐Rican women aged 18–40, who reported sexual activities were interviewed.MeasuresWe used data regarding sociodemographic factors, Latino acculturation, a single violence question of “Did your partner hit or hurt you in any way?” and the CTS2 measuring intimate partner violence.ResultsUsing the CTS2 as a gold standard, the sensitivity and specificity of a single question for screening partner physical violence was 45.9% and 94.7%, respectively. The positive likelihood ratio of a single question for physical violence was 8.59. The sensitivity, specificity, and likelihood ratio of a single question for screening psychological aggression were 17.9%, 98.5%, and 11.89, respectively.ConclusionWhile a single question used in our study needs further improvement for desirable sensitivity, it may be usable as an initial question for detecting IPV.
The effect of peer support groups on family adaptation from the perspective of wives of war veterans with posttraumatic stress disorder
Authors: Vagharseyyedin Seyyed Abolfazl , Gholami Mojtaba , Hajihoseini Morteza , Esmaeili Aliakbar 
Published: August 2017

AbstractObjectiveThe aim of this study was to examine the effect of peer group support on family adaptation of wives of war veterans suffering from post‐traumatic stress disorder (PTSD).Design and SampleIn this randomized controlled trial, 80 wives of war veterans with PTSD were incorporated, and selected participants were randomly assigned into intervention and control groups (n = 40 per group). The intervention group was divided into four subgroups, with each participating in eight weekly based 1.5‐hr peer support group sessions and the control group received no intervention.MeasuresDemographics form and Family Adaptation Scale (FAS) developed by Antonovsky and Sourani (1988) were applied.ResultsThe total mean scores of family adaptation increased significantly more in the intervention group than in the control group (p = .033). Furthermore, the time × group interaction effects were significant for internal family fit (p = .013) and a combination of both family fit and family community fit (p = .020) dimensions. Nonetheless family fit dimensions mean scores had no significant increase in the intervention group than the control group over time (p = .948).ConclusionsPeer support group can be a useful tool for health care professionals to enhance family adaptation in spouses of war veterans with PTSD.
Maternal Body Mass Index and Regional Anaesthesia Use at Term: Prevalence and Complications
Authors: Biel Frances M. , Marshall Nicole E. , Snowden Jonathan M. 
Published: August 2017

AbstractBackgroundThere is an evidence gap regarding the use of regional anaesthesia (epidural, spinal, or combined epidural/spinal anaesthesia) and associated complications by maternal body mass index (BMI). We examine associations between regional anaesthesia, mode of delivery, and regional anaesthesia complications by pre‐pregnancy BMI categories among term deliveries.MethodsRetrospective cohort study of births in California, 2007‐2010, utilizing linked birth certificate data and patient discharge data. Outcomes were mode of delivery (among laboured deliveries) and select regional anaesthesia complications. Multivariable Poisson regression was used to adjust for maternal characteristics.ResultsIn women undergoing labour (i.e. laboured delivery), women with higher BMI categories were more likely to receive regional analgesia in a dose–response fashion (adjusted risk ratio [RR] 1.10, 95% confidence interval [CI] 1.10, 1.11 for primiparous women with category I obesity), and in those receiving regional anaesthesia, were less likely to deliver vaginally (e.g. RR 0.85, 95% CI 0.84, 0.85 for the same category of women). Regional anaesthesia complications displayed a complex relationship with maternal BMI, with women in intermediate obesity categories having decreased odds as compared to normal‐weight women, and women in the highest BMI category having a twofold increased risk of complications (RR 2.34, 95% CI 1.37, 4.02 for primiparous women).ConclusionLabouring women in higher BMI categories were more likely to receive regional anaesthesia and more likely to deliver via caesarean compared to normal weight women and women without regional anaesthesia. Rates of anaesthesia complications were highest among women in the highest BMI category.
A Naturalist Ontology of Instantiation
Authors: Cumpa Javier 
Published: August 2017

AbstractThe aim of this paper is to defend a naturalistic approach to instantiation and the Principle of Instantiation. I argue that the instantiation of an ordinary property F consists of two coordinated relationships at the levels of the manifest and scientific images, namely, constituency and entailment. Also, I offer an account of the Principle of Instantiation related to this conception of instantiation based on the notion of scientific prediction.
Genotype and attachment technique influence the growth and survival of line nursery corals
Authors: Goergen Elizabeth A. , Ostroff Zachary , Gilliam David S. 
Published: August 2017

AbstractThe Caribbean staghorn coral, Acropora cervicornis, was once a dominant habitat creating coral, but its populations have declined dramatically in recent decades. Numerous restoration efforts now utilize coral gardening techniques to cultivate this species, growing colonies on fixed structures or from line/suspended nurseries. Line nurseries have become increasingly popular because of their small footprint and ease of use, replacing fixed structures in many nurseries. To evaluate the efficacy of the line technique, this study evaluated growth, condition, and survivorship of A. cervicornis nursery colonies of three distinct genotypes grown via two line nursery techniques (suspended and direct line attachment [vertical]). Direct line attachment of nursery colonies resulted in poor survival (43%) and growth (9.5 ± 1.33 cm/year), whereas suspended culture had 100% survival and increased growth (61.1 ± 4.19 cm/year). Suspended culture had significantly reduced disease prevalence and prevented colony predation. Suspended coral growth was also comparable to a neighboring fixed structure nursery (55.2 ± 7.86 cm/year), and found to be as effective in propagating corals as fixed structures.
Rapid understory plant recovery following forest floor protection on temporary drilling pads
Authors: Jones Caren E. , Bachmann Sascha , Lieffers Victor J. , Landhäusser Simon M. 
Published: August 2017

AbstractOil sands exploration fragments the boreal landscape by constructing numerous drilling pads to assess underground petroleum reserves. Reclamation of these pads is challenging and slow, particularly for forest understory species. We investigated the feasibility of accelerated forest understory restoration on these temporary pads by taking advantage of the propagule bank and clonal regeneration strategy of many boreal plants. We covered and protected the forest floor (FF) with subsoil during winter pad construction. This forest floor protection (FFP) method was then compared with the current practice of stripping off, stockpiling, and then replacing the FF during the reclamation phase (rollback, RB) and to conventional clearcut (CC) harvesting. In the first growing season, surface disturbance as well as richness and cover of plant regeneration was evaluated; vegetation assessment was repeated in the fifth growing season. Although there were some slight differences between the communities in the FFP and CC treatments, likely associated with varying levels of residual slash and subsoil material, there were striking differences between the communities in the RB and FFP treatments. In addition, while establishment of deciduous tree species was similar between the FFP and CC treatments, there were very few trees found in the RB treatment. The study indicates that protection and careful uncovering of the FF during temporary drilling pad construction should be a technique of choice for forest reclamation used in the boreal forest. However, as RB will still play a part in the reclamation of these sites, management intervention will be required to achieve reclamation goals.
Bumble bee colony growth and reproduction on reclaimed surface coal mines
Authors: Lanterman Jessie , Goodell Karen 
Published: August 2017

AbstractReclamation of coal mine lands in the eastern United States creates pockets of grassland habitat in an otherwise predominantly forested region. These sites may represent an opportunity for pollinator conservation if they provide valuable foraging habitat for wild bees. To determine site characteristics that influence bee success on reclamation lands, we monitored growth and reproduction of 24 commercially reared bumble bee (Bombus impatiens) colonies placed on 12 former coal mines (aged 2 to 30+ years post‐reclamation) in Ohio, U.S.A. Twenty colonies survived the duration of the experiment (May–August 2014). All colonies produced both new queens (mean 21.0 ± 37.0 SD) and males (36.5 ± 36.5), in proportion to overall colony size. Results of generalized linear models indicate that colony growth and reproduction increased with floral diversity and species turnover, and declined with site area and the proportion of forest in the surrounding landscape. The sex ratio of reproductive offspring was significantly more male‐biased on sites with low flower diversity, underscoring the importance of floral diversity for meeting the higher resource demands of queen production. Floral resource composition and consistency were influenced by site age and surrounding landscape. Older sites had higher floral diversity and species turnover throughout the season than younger sites, and included high‐quality native bee forage plants. We discuss the implications of this study for reclamation project managers seeking to promote bee reproduction and conservation.
VEGF synthesis is induced by prostacyclin and TGF‐β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling
Authors: Westergren‐Thorsson Gunilla , Bagher Mariam , Andersson‐Sjöland Annika , Thiman Lena , Löfdahl Claes‐Göran , Hallgren Oskar , Bjermer Leif , Larsson‐Callerfelt Anna‐Karin 
Published: August 2017

ABSTRACTBackground and objectiveInvolvement of pulmonary vascular remodelling is a characteristic sign in COPD. Vascular mediators such as vascular endothelial growth factor (VEGF) and prostacyclin may regulate fibroblast activity. The objective was to study the synthesis of VEGF and interactions with prostacyclin and transforming growth factor (TGF)‐β1 in lung fibroblasts from patients with COPD and healthy control subjects. To further explore the autocrine role of synthesized VEGF on fibroblast activity, studies were performed in human lung fibroblasts (HFL‐1).MethodsPrimary distal lung fibroblast cultures were established from healthy individuals and from COPD patients (GOLD stage IV). Lung fibroblasts were stimulated with the prostacyclin analogue iloprost and the profibrotic stimuli TGF‐β1. VEGF synthesis was measured in the cell culture medium. Changes in proliferation rate, migration and synthesis of the extracellular matrix (ECM) proteins proteoglycans were analysed after stimulations with VEGF‐A isoform 165 (VEGF165; 1–10 000 pg/mL) in HFL‐1.ResultsIloprost and TGF‐β1 significantly increased VEGF synthesis in both fibroblasts from COPD patients and control subjects. TGF‐β1‐induced VEGF synthesis was significantly reduced by the cyclooxygenase inhibitor indomethacin in fibroblasts from COPD patients. VEGF significantly increased proliferation rate and migration capacity in HFL‐1. VEGF also significantly increased synthesis of the ECM proteins biglycan and perlecan. The VEGF receptors (VEGFR), VEGFR1, VEGFR2 and VEGFR3, were all expressed in primary lung fibroblasts and HFL‐1.ConclusionVEGF is synthesized in high amounts by distal lung fibroblasts and may have a crucial role in ongoing vascular remodelling processes in the distal lung compartments.
Identifying foreign suppliers in U.S. import data
Authors: Kamal Fariha , Monarch Ryan 
Published: August 2017

AbstractRelationships between firms and their foreign suppliers are the foundation of international trade, but data limitations and reliability concerns make studying such relationships challenging. We evaluate and enhance supplier information in U.S. import data and present new facts about importer–exporter relationships. Count of foreign exporters from U.S. import data tends to exceed those from source country data, especially from China. The pattern of U.S. imports from origin countries changes substantially by tracing trade back to the supplier's location instead. Related‐party relationships trade more, while larger countries have more relationships.
Two‐Aggregate Games: Demonstration Using a Production–Appropriation Model
Authors: Cornes Richard , Hartley Roger , Tamura Yuji 
Published: August 2017

AbstractWe expand the scope of the two‐aggregate method by applying it to a situation in which many heterogeneous players are free to contribute to both aggregates. Such situations naturally arise in various resource allocation problems. Hence, our method is useful in many applications. A production–appropriation model is employed to illustrate how the problem of establishing the Nash equilibrium can be reduced from solving n>2 best‐response functions in n unknowns to solving two consistency conditions in two unknowns. We then conduct a comparative static exercise that the conventional approach could not handle easily, if at all, to demonstrate the power of our method.
The psychometric properties of the Portuguese version of the Personality Inventory for DSM‐5
Authors: Pires Rute , Sousa Ferreira Ana , Guedes David 
Published: August 2017

The DSM‐5 Section III proposes a hybrid dimensional‐categorical model of conceptualizing personality and its disorders that includes assessment of impairments in personality functioning (criterion A) and maladaptive personality traits (criterion B). The Personality Inventory for the DSM‐5 is a new dimensional tool, composed of 220 items organized into 25 facets that delineate five higher order domains of clinically relevant personality differences, and was developed to operationalize the DSM‐5 model of pathological personality traits. The current studies address the internal consistency (study 1), the test‐retest reliability (study 2) and the criterion validity (studies 3 and 4) of the Portuguese version of the PID‐5 in samples of native speaking psychology students. Results indicated good internal consistency reliabilities and good temporal stability reliabilities for the majority of the PID‐5 traits. The correlational pattern of the PID‐5 traits with two measures of personality was in accordance with theoretical expectations and showed its concurrent validity.