bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory myofibroblastic tumor mimicking a relapse in a patient with Hodgkin's lymphoma: report of an unusual case and review of the literature
Authors: Özbalak Murat , Torun Ege Sinan , Özdemirli Metin , Uçar Ali Rıza , Akpınar Timur Selçuk , Taşçıoğlu Cemil , Ferhanoğlu Burhan 
Published: May 2017

Key Clinical MessageNew PET‐positive lesions in previously treated patients with lymphomatous malignancies need further investigations. Relapse, sarcoidosis and secondary malignancies are the most important differential diagnosis. Inflammatory myofibroblastic tumors (IMT) is a rare complication after treatment of Hodgkin's disease and every PET‐positive lesion should be biopsied to prevent unnecessary intervention.
Cs‐Corrected STEM Imaging of both Pure and Silver‐Supported Metal‐Organic Framework MIL‐100(Fe)
Authors: Mayoral Alvaro , Mahugo Rubén , Sánchez‐Sánchez Manuel , Díaz Isabel 
Published: May 2017

AbstractMetal‐organic frameworks (MOFs) are a family of porous solids combining organic and inorganic moieties with tunable porosity. Their structural parameters have converted MOFs into suitable compounds for gas storage or drug delivery. However, despite the excellent crystallinity they tend to exhibit their analysis through transmission electron microscopy is extraordinarily complicated owing to the high instability under the electron beam irradiation. In here, high‐resolution Cs‐corrected STEM imaging was used for the observation of the building units of MIL‐100(Fe), and special attention was paid to the electron beam current. In addition, MIL‐100(Fe) was reacted with AgNO3 through a solid‐state reaction technique, which resulted into the formation of metal nanoparticles on the surface. The incorporation of Ag into the porous network has been also investigated.
Palladium‐Catalyzed Carbonylative Cyclization of Azoarenes
Authors: Wang Zechao , Yin Zhiping , Zhu Fengxiang , Li Yahui , Wu Xiao‐Feng 
Published: May 2017

AbstractIn this communication, we established an interesting palladium‐catalyzed carbonylation protocol for the intramolecular cyclization of azoarenes. With Mo(CO)6 as the solid CO source and through C(sp2)−H bond activation, a series of azoarenes were transformed into the corresponding 2‐arylindazolones in moderate to good yields. Notably, not only symmetrical azoarenes, but also unsymmetrical substrates underwent the reaction with excellent regioselectivity.
Influence of Liquid‐Liquid Phase Separation on the Crystallization of L‐Menthol from Water
Authors: de Albuquerque Ian , Mazzotti Marco 
Published: May 2017

AbstractThe crystallization of L‐menthol in water was investigated, with the intent of understanding the effect that liquid‐liquid phase separation (LLPS) has on the properties of product crystals. First, the binary phase diagram was measured, comprising both solid‐liquid and liquid‐liquid equilibrium regions. Calibration for the online monitoring of solid and liquid‐liquid suspension densities was performed using Raman spectroscopy, thus enabling the detection of LLPS and crystallization. Crystallization was monitored online also by Raman spectroscopy. Offline characterization was performed using differential scanning calorimetry, powder X‐ray diffraction, and Karl‐Fisher. Crystallization followed by LLPS led to the formation of the most stable polymorphic form, yet those solids contained solvent inclusions. The initial amount of inclusions proved to be a function of operating conditions, namely cooling rate and suspension density.
CO2 Capture from Air Using Amine‐Functionalized Kaolin‐Based Zeolites
Authors: Thakkar Harshul , Issa Ahlam , Rownaghi Ali A. , Rezaei Fateme 
Published: May 2017

AbstractSeveral inexpensive zeolites such as ZSM‐5 (MFI), zeolite Y (FAU), and SAPO‐34 (CHA) were developed from kaolin clay and applied for CO2 capture from air. These molecular sieves were functionalized with tetraethylenepentamine (TEPA) in order to further improve their CO2 capacity. The obtained kaolin‐based zeolites exhibited similar properties than those of zeolites prepared with other sources. They also revealed a bimodal pore network consisting of both micropores and mesopores. The effect of amine loading on CO2 capture was investigated and the results demonstrated that TEPA‐modified zeolite Y with 10 wt % TEPA had a higher capacity than other zeolites due to its larger mesopore volume. The presence of mesopores in the zeolite Y framework facilitated a better accessibility of CO2 molecules to the amine sites.
Bidirectional Access to Radical Cation Diels‐Alder Reactions by Electrocatalysis
Authors: Ozaki Atsushi , Yamaguchi Yusuke , Okada Yohei , Chiba Kazuhiro 
Published: May 2017

AbstractUmpolung is a classic and central concept in synthesis that produces a reversal of the normal reactivity of the molecules under study. The most straightforward method for umpolung involves an electron transfer reaction. The present study describes bidirectional access to radical cation Diels‐Alder reactions by electrocatalysis. The radical cation either of trans‐anethole or 9‐methylanthracene could trigger the reaction, which was confirmed unambiguously through the use of silica‐gel‐supported substrates.
Modeling Fungal Melanin Buildup: Biomimetic Polymerization of 1,8‐Dihydroxynaphthalene Mapped by Mass Spectrometry
Authors: Cecchini Martina Maya , Reale Samantha , Manini Paola , d'Ischia Marco , De Angelis Francesco 
Published: May 2017

AbstractDue to the emerging biomedical relevance and technological potential of fungal melanins, and prompted by the virtual lack of information about their structural arrangement, an optimized synthetic protocol has been devised for a potential structural model of Ascomyces allomelanin through enzyme‐catalyzed oxidative polymerization of 1,8‐dihydroxynaphthalene (1,8‐DHN). Electrospray ionization mass spectrometry (ESI‐MS) measurements of freshly synthesized DHN‐polymer recorded in the negative ion mode allowed detection of oligomers up to m/z 4000, separated by 158 Da, corresponding to the in‐chain DHN‐unit. The dominant peaks were assigned to singly‐charged distribution, up to 23 repeating units, whereas a doubly charged polymer distribution was also detectable. Chemical derivatization, ultra‐performance liquid chromatography (UPLC)‐ESI MS, and MS/MS data confirmed that oxidative polymerization of 1,8‐DHN proceeds through C−C coupling of the naphthalene rings. The new insights reported here into synthetic 1,8‐DHN oligomers/polymers as a mimic of fungal melanins may guide novel interesting advances and applications in the field of biomimetic functional materials.
Cancer as a stressful life event: Perceptions of children with cancer and their peers
Authors: Sharp Katianne M. Howard , Lindwall Jennifer J. , Willard Victoria W. , Long Alanna M. , Martin‐Elbahesh Karen M. , Phipps Sean 
Published: May 2017

BACKGROUNDThe medical traumatic stress model is commonly applied to childhood cancer, assuming that the diagnosis of cancer is a traumatic event. However, to the authors' knowledge, little is known regarding what specifically children perceive as stressful about cancer or how it compares with other stressful events more often experienced by children.METHODSChildren with cancer (254 children) and demographically similar peers without a history of serious illness (202 children) identified their most stressful life event as part of a diagnostic interview assessing for symptoms of posttraumatic stress disorder (PTSD). The events identified as most stressful were categorized thematically, with categories established separately for cancer‐related and non‐cancer‐related events. Events also were examined to assess whether they met Diagnostic and Statistical Manual of Mental Disorders (DSM) A criteria for PTSD.RESULTSIn the group of children with cancer, 54% described a cancer‐related event as the most stressful event they had experienced. Six distinct categories of cancer‐related events and 10 categories of non‐cancer‐related events were identified. The same noncancer events were identified by children in both groups, and occurred at similar frequencies. The percentage of cancer‐related events that met DSM A criteria for PTSD differed dramatically depending on which version of the DSM was applied.CONCLUSIONSChildren do not necessarily view their cancer experience as their most stressful life event. The findings of the current study suggest that the diagnosis of cancer might be better viewed as a manageable stressor rather than a major trauma, and are consistent with the change in the fifth edition of the DSM to eliminate the diagnosis of a life‐threatening illness as a qualifying trauma for PTSD. Cancer 2017;123:3385‐93. © 2017 American Cancer Society.
Impact of travel distance to the treatment facility on overall mortality in US patients with prostate cancer
Authors: Vetterlein Malte W. , Löppenberg Björn , Karabon Patrick , Dalela Deepansh , Jindal Tarun , Sood Akshay , Chun Felix K.‐H. , Trinh Quoc‐Dien , Menon Mani , Abdollah Firas 
Published: May 2017

BACKGROUNDThe objective of this study was to investigate the impact of travel distance to the treating facility on the risk of overall mortality (OM) among US patients with prostate cancer (PCa).METHODSIn total, 775,999 patients who had PCa in all stages and received treatment with different strategies (radical prostatectomy, radiation therapy, observation, androgen‐deprivation therapy, multimodal treatment, and chemotherapy) were drawn from the National Cancer Data Base from 2004 through 2012. Independent predictors of travel distance (intermediate [12.5‐49.9 miles] and long [49.9‐249.9 miles] vs short[<12.5 miles]) and its effect on OM were calculated using multivariable regression analyses. Additional analyses evaluated the distance effect on OM in selected subgroups.RESULTSIn total, 54.5%, 33.4%, and 12.1% of patients traveled short, intermediate, and long distances, respectively. Residency in rural areas and the receipt of treatment at academic/high‐volume centers independently predicted long travel distance. Non‐Hispanic black men and Medicaid‐insured men were less likely to travel long distances (all P < .001). Overall, traveling a long distance (hazard ratio, 0.87; 95% confidence interval, 0.83‐0.92; P < .001) was associated with lower OM risk compared with traveling a short distance. This held true among non‐Hispanic white men; privately insured and Medicare‐insured men; those who underwent radical prostatectomy, received radiation therapy, and received multimodal strategies; and those who received treatment at academic/high‐volume centers (P < .01), but not among non‐Hispanic black men (P = .3). Long travel distance was associated with an increased OM in Medicaid‐insured patients (P < .001).CONCLUSIONSAn OM benefit was observed among men who traveled long distances for PCa treatment, which is likely to be a reflection of centralization of care and more favorable patient‐level characteristics in those travelers. Furthermore, the survival benefit mediated by long travel distances appears to be influenced by baseline socioeconomic, treatment, and facility‐level factors. Cancer 2017;123:3241‐52. © 2017 American Cancer Society.
Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain
Authors: Merchan‐Sala Paloma , Nardini Diana , Waclaw Ronald R. , Campbell Kenneth 
Published: May 2017

AbstractThe striatum is the major component of the basal ganglia and is well known to play a key role in the control of motor function via balanced output from the indirect (iSPNs) and direct pathway striatal projection neurons (dSPNs). Little is known, however, about the molecular genetic mechanisms that control the formation of the iSPNs versus dSPNs. We show here that the SoxE family member, Sox8, is co‐expressed with the dSPN markers, Isl1 and Ebf1, in the developing striatum. Moreover, dSPNs, as marked by Isl1‐cre fate map, express Sox8 in the embryonic striatum and Sox8‐EGFP BAC transgenic mice specifically reveal the direct pathway axons during development. These EGFP+ axons are first observed to reach their midbrain target, the substantia nigra pars reticulata (SNr), at E14 in the mouse with a robust connection observed already at birth. The selective expression of EGFP in dSPNs of Sox8‐EGFP BAC mice is maintained at postnatal timepoints. Sox8 is known to be expressed in oligodendrocyte precursor cells (OPCs) together with other SoxE factors and we show here that the EGFP signal co‐localizes with the OPC markers throughout the brain. Finally, we show that Sox8‐EGFP BAC mice can be used to interrogate the altered dSPN development in Isl1 conditional mutants including aberrant axonal projections detected already at embryonic timepoints. Thus, Sox8 represents an early and specific marker of embryonic dSPNs and the Sox8‐EGFP BAC transgenic mice are an excellent tool to study the development of basal ganglia circuitry.
Multiple cell types form the VIP amacrine cell population
Authors: Pérez de Sevilla Müller Luis , Solomon Alexander , Sheets Kristopher , Hapukino Hinekura , Rodriguez Allen R. , Brecha Nicholas C. 
Published: May 2017

AbstractAmacrine cells are a heterogeneous group of interneurons that form microcircuits with bipolar, amacrine and ganglion cells to process visual information in the inner retina. This study has characterized the morphology, neurochemistry and major cell types of a VIP‐ires‐Cre amacrine cell population. VIP‐tdTomato and ‐Confetti (Brainbow2.1) mouse lines were generated by crossing a VIP‐ires‐Cre line with either a Cre‐dependent tdTomato or Brainbow2.1 reporter line. Retinal sections and whole‐mounts were evaluated by quantitative, immunohistochemical, and intracellular labeling approaches. The majority of tdTomato and Confetti fluorescent cell bodies were in the inner nuclear layer (INL) and a few cell bodies were in the ganglion cell layer (GCL). Fluorescent processes ramified in strata 1, 3, 4, and 5 of the inner plexiform layer (IPL). All tdTomato fluorescent cells expressed syntaxin 1A and GABA‐immunoreactivity indicating they were amacrine cells. The average VIP‐tdTomato fluorescent cell density in the INL and GCL was 535 and 24 cells/mm2, respectively. TdTomato fluorescent cells in the INL and GCL contained VIP‐immunoreactivity. The VIP‐ires‐Cre amacrine cell types were identified in VIP‐Brainbow2.1 retinas or by intracellular labeling in VIP‐tdTomato retinas. VIP‐1 amacrine cells are bistratified, wide‐field cells that ramify in strata 1, 4, and 5, VIP‐2A and 2B amacrine cells are medium‐field cells that mainly ramify in strata 3 and 4, and VIP‐3 displaced amacrine cells are medium‐field cells that ramify in strata 4 and 5 of the IPL. VIP‐ires‐Cre amacrine cells form a neuropeptide‐expressing cell population with multiple cell types, which are likely to have distinct roles in visual processing.
Innervation of the syrinx of the zebra finch (Taeniopygia guttata)
Authors: Faunes Macarena , Botelho João F. , Wild J. Martin 
Published: May 2017

AbstractIn songbirds, the learning and maintenance of song is dependent on auditory feedback, but little is known about the presence or role of other forms of sensory feedback. Here, we studied the innervation of the avian vocal organ, the syrinx, in the zebra finch. Using a combination of immunohistochemistry, immunofluorescence and neural tracing with subunit B of cholera toxin (CTB), we analysed the peripheral and central endings of the branch of the hypoglossal nerve that supplies the syrinx, the tracheosyringeal nerve. In the syringeal muscles, we show the presence of numerous choline acetyl transferase‐like immunoreactive en plaque motor endplates and substance P‐like immunoreactive, thin and varicose free nerve endings. Substance P‐like immunoreactive free nerve endings were also present in the luminal syringeal tissues, especially in the luminal epithelium of the trachea and pessulus. Also, by a combination of immunofluorescence and transganglionic tracing following injections of CTB in the tracheosyringeal nerve, we identified as central targets of the syringeal receptors the caudolateral part of the interpolaris subnucleus of the descending trigeminal tract, a caudolateral region of the nucleus tractus solitarius, and a lateral band of the principal sensory trigeminal nucleus. Further studies are required to determine the sensory modalities of these receptors and the connections of their specific synaptic targets.
Cross‐Linked Sulfur–Selenium Polymers as Hole‐Transporting Materials in Dye‐Sensitized Solar Cells and Perovskite Solar Cells
Authors: Liu Peng , Kloo Lars , Gardner James M. 
Published: May 2017

AbstractNovel inverse‐vulcanized polymeric sulfur–selenium materials (SeS2:S:DIB, where DIB=1,3‐diisopropenylbenzene) have been prepared and utilized for solid‐state dye‐sensitized solar cells and perovskite solar cells. Under standard AM 1.5G illumination (1000 W m−2), a power conversion efficiency of 1.70 % was recorded for polymeric sulfur–selenium–based (SeS2:S:DIB) solid‐state solar cells, which is higher than that of polymeric sulfur‐based (S:DIB) devices (1.09 %). For perovskite solar cells, a relatively high efficiency has been achieved for polymeric sulfur–selenium‐based (SeS2:S:DIB) solar cells (10.21 %) and polymeric sulfur‐based (S:DIB; 7.32 %) solar cells, respectively. The conductivity of the polymeric SeS material has been determined to 2.24×10−4 S cm−1, which is higher than for the polymeric sulfur material under the same doping conditions. Photoinduced absorption and steady‐state photoluminescence measurements were performed to investigate the charge‐transfer properties relevant for the solar cells. The results in the present study qualify the new polymeric sulfur–selenium materials as candidates for low‐cost hole‐transport materials for photovoltaic devices.
Remarkable Solvatofluorochromism of a [2.2]Paracyclophane‐Containing Organoboron Complex: A Large Stokes Shift Promoted by Excited State Intramolecular Charge Transfer
Authors: Tanaka Mirai , Muraoka Shunsuke , Matsui Yasunori , Ohta Eisuke , Sakai Atsushi , Ogaki Takuya , Yoshimoto Yuichi , Mizuno Kazuhiko , Ikeda Hiroshi 
Published: May 2017

AbstractThe front cover artwork is provided by the group of Prof. Dr. Hiroshi Ikeda at Osaka Prefecture University (Japan). The picture represents the luminescence associated with geometrical changes of a molecule in the photoexcited state. Drops of rainwater from the π‐electron clouds accumulate in a water bottle. When water finally flows out of a tilted bottle, luminescence is observed. Read the full text of the article at 10.1002/cptc.201600028.
Sustainable Gel Electrolyte Containing Pyrazole as Corrosion Inhibitor and Dendrite Suppressor for Aqueous Zn/LiMn2O4 Battery
Authors: Hoang Tuan K. A. , Doan The Nam Long , Cho Julie Hyeonjoo , Su Jane Ying Jun , Lee Christine , Lu Changyu , Chen P. 
Published: May 2017

AbstractThe Zn anode in secondary aqueous batteries suffers from dendrite formation and corrosion. In this work, dendrite formation was suppressed by using a simple but new gel electrolyte containing fumed silica and an additive. The dendrite suppression was evidenced by chronoamperometry and ex situ scanning electron microscopy examinations. Pyrazole was implemented as the additive in the electrolyte. It was found that the presence of 0.2 wt % pyrazole in the electrolyte helped minimize both corrosion and dendrite formation. The Zn/LiMn2O4 battery using pyrazole‐containing gel electrolytes exhibited high cyclability up to 85 % capacity retention after 500 charge–discharge cycles at 4C. This was 8 % higher than the performance of the reference battery (using aqueous electrolyte containing 2 m Li2SO4 and 1 m ZnSO4). Furthermore, self‐discharge of the battery with the pyrazole‐containing gel electrolyte was suppressed, as evidenced by an open‐circuit voltage loss that was 20 % lower than for the reference battery after 24 h monitoring. Float‐charge current density under constant voltage (2.1 V) also significantly decreased from approximately 8.0 to 3–6 μA.
Nullor‐based circuits for quantum technology
Authors: Hoekstra J. 
Published: May 2017

SummaryThe purpose of this paper is to review and derive circuit models to support the synthesis of circuits and systems to be used for reading out devices based on quantum technology. In quantum technology, reading out devices is difficult; measuring may destroy the information stored in the quantum system. Optimal design can be achieved by signal processing circuits based on the nullor that, theoretically, do not extract power and thus energy from the system. Because of the nullator properties at the input of the nullor two‐port and the norator properties of the output of the nullor, signals can be tapped from the quantum system without absorbing power from it; energy to do so is provided by external sources. Circuits based on the nullor are theoretically circuits for reading out signals from devices in quantumtimal circuits for reading out signals from devices in quantum systems and for processing this data afterwards. In the paper, basic sensing circuit concepts based on the nullor and their descriptions based on the chain‐matrix (K‐matrix) are presented. Some possible candidates for implementing the theoretical schemes are discussed, and as a possible application, a single‐electron tunneling electrometer is described. Copyright © 2017 John Wiley & Sons, Ltd.
A 300‐mA load CMOS low‐dropout regulator without an external capacitor for SoC and embedded applications
Authors: Huang S. , Duan Quanzhen , Guo Tian , Cheng Yaping , Yin Jiaqi , Ding Yue Min 
Published: May 2017

SummaryThis study proposes a 300‐mA external capacitor‐free low‐dropout (LDO) regulator for system‐on‐chip and embedded applications. To achieve a full‐load range from 0 to 300 mA, a two‐scheme (a light‐load case and a heavy‐load case) operation LDO regulator with a novel control circuit is proposed. In the light‐load case (0–0.5 mA), only one P‐type metal–oxide–semiconductor input‐pair amplifier with a 10‐pF on‐chip capacitor is used to obtain a load current as low as 0. In the heavy‐load case (0.5 to 300 mA), both P‐type metal–oxide–semiconductor and N‐type metal–oxide–semiconductor differential input‐pair amplifiers with an assistant push‐pull stage are utilized to improve the stability of the LDO regulator and achieve a high slew rate and fast‐transient response. Measurements show an output voltage of 3.3 V and a full output load range from 0 to 300 mA. A line regulation of 1.66 mV/V and a load regulation of 0.0334 mV/mA are achieved. The measured power‐supply rejection ratio at 1 kHz is −65 dB, and the measured output noise is only 34 μV. The total active chip size is approximately 0.4 mm2 with a standard 0.5 μm complementary metal–oxide–semiconductor process. Copyright © 2017 John Wiley & Sons, Ltd.