bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panobinostat plus bortezomib and dexamethasone: impact of dose intensity and administration frequency on safety in the PANORAMA 1 trial
Authors: San‐Miguel Jesús F. , Hungria Vania T. M. , Yoon Sung‐Soo , Beksac Meral , Dimopoulos Meletios A. , Elghandour Ashraf , Jedrzejczak Wieslaw W. , Guenther Andreas , Na Nakorn Thanyaphong , Siritanaratkul Noppadol , Schlossman Robert L. , Hou Jian , Moreau Philippe , Lonial Sagar , Lee Jae‐Hoon , Einsele Hermann , Salwender Hans , Sopala Monika , Redhu Suman , Paul Sofia , Corrado Claudia , Richardson Paul G. 
Published: June 2017

SummaryPanobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression‐free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in Multiple Myeloma 1) trial. Despite this benefit, patients in the panobinostat arm experienced higher rates of adverse events (AEs) and higher rates of discontinuation due to AEs. This PANORAMA 1 subanalysis examined AEs between 2 treatment phases of the study (TP1 and TP2), in which administration frequency of bortezomib and dexamethasone differed per protocol. The incidences of several key AEs were lower in both arms following the planned reduction of bortezomib dosing frequency in TP2. In the panobinostat arm, rates of thrombocytopenia (grade 3/4: TP1, 56·7%; TP2, 6·0%), diarrhoea (grade 3/4: TP1, 24·1%; TP2, 7·1%), and fatigue (grade 3/4: TP1, 16·3%; TP2, 1·8%) were lower in TP2 compared with TP1. Dose intensity analysis of panobinostat and bortezomib by cycle in the panobinostat arm showed reductions of both agent doses during cycles 1–4 due to dose adjustments for AEs. Exposure‐adjusted analysis demonstrated a reduction in thrombocytopenia frequency in TP1 following dose adjustment. These results suggest that optimization of dosing with this regimen could improve tolerability, potentially leading to improved patient outcomes.
Internet use, risks and online behaviour: The view of internet users with intellectual disabilities and their caregivers
Authors: Chiner Esther , Gómez‐Puerta Marcos , Cardona‐Moltó María Cristina 
Published: June 2017

Accessible summary

Going online is important because we can learn, meet people and get information. But some actions by others or by ourselves can be harmful.

We wanted to find out how people with intellectual disabilities in Spain go online and the problems they have using the Web.

We asked 77 adults with intellectual disabilities and 68 caregivers to answer questions about how people with intellectual disabilities use the Web.

We found that people with intellectual disabilities prefer smartphones to go online and that they listen to music, watch videos or chat with friends online.

We also found out that sometimes they have problems such as receiving insults or being blocked.

AbstractBackgroundInternet offers opportunities to people with intellectual disabilities, but it also involves some risks. The aim of this study was to explore these issues considering caregivers and people with intellectual disabilities’ perspectives.Materials and MethodsA descriptive, cross‐sectional study was conducted. The sample consisted of 77 adults with intellectual disabilities and 68 caregivers from a Spanish service provider organisation.ResultsCompared to previous research, findings show an increasing use of electronic devices such as smartphones and the Internet by people with intellectual disabilities. Some online risks (e.g., being insulted, being threatened, someone using their personal information) and undesirable behaviours of this group (e.g., insulting, threatening or flirting with someone who did not want to) were also identified. Differences between the responses of people with intellectual disabilities and their caregivers were found with regard to people with intellectual disabilities’ online behaviour.ConclusionsIt is important to design, validate and implement strategies to promote risk management and positive risk‐taking actions for people with intellectual disabilities.
Dividing Attention Between Tasks: Testing Whether Explicit Payoff Functions Elicit Optimal Dual‐Task Performance
Authors: Farmer George D. , Janssen Christian P. , Nguyen Anh T. , Brumby Duncan P. 
Published: June 2017

AbstractWe test people's ability to optimize performance across two concurrent tasks. Participants performed a number entry task while controlling a randomly moving cursor with a joystick. Participants received explicit feedback on their performance on these tasks in the form of a single combined score. This payoff function was varied between conditions to change the value of one task relative to the other. We found that participants adapted their strategy for interleaving the two tasks, by varying how long they spent on one task before switching to the other, in order to achieve the near maximum payoff available in each condition. In a second experiment, we show that this behavior is learned quickly (within 2–3 min over several discrete trials) and remained stable for as long as the payoff function did not change. The results of this work show that people are adaptive and flexible in how they prioritize and allocate attention in a dual‐task setting. However, it also demonstrates some of the limits regarding people's ability to optimize payoff functions.
Antibacterial resistance and the success of tailored triple therapy in Helicobacter pylori strains isolated from Slovenian children
Authors: Butenko Tita , Jeverica Samo , Orel Rok , Homan Matjaž 
Published: June 2017

AbstractBackgroundPrimary Helicobacter pylori (H. pylori) infection occurs predominantly in childhood. Antimicrobial resistance is the leading cause for H. pylori eradication failure. The aims of this study were (i) to establish for the first time the antimicrobial resistance of H. pylori strains in infected Slovenian children not previously treated for H. pylori infection and (ii) to evaluate the effectiveness of tailored triple therapy, assuming that eradication rate with tailored triple therapy will be >90%.MethodsData on all treatment‐naive children 1‐18 years old and treated for H. pylori infection according to susceptibility testing were retrospectively analyzed. All relevant clinical information and demographical information were retrospectively collected from the hospital information systems and/or patients’ medical documentation.ResultsThe inclusion criteria were met by 107 children (64.5% girls) with a median age of 12.0 years (range 2.0‐17.6 years). Primary antimicrobial resistance rates of H. pylori were 1.0% to amoxicillin (AMO), 23.4% to clarithromycin (CLA), 20.2% to metronidazole (MET), 2.8% to levofloxacin (LEV), and 0.0% to tetracycline (TET). Dual resistances were detected to CLA and MET in 11.5% (n=12) of strains, to CLA and LEV in 2.8% (n=3), and to MET and LEV in 2.9% (n=3). Results of treatment success were available for 71 patients (66.2% girls). Eradication of H. pylori was evaluated using the 13C‐urea breath test, monoclonal stool antigen test or in some cases with repeated upper GI endoscopy with histology and cultivation/molecular tests. Eradication was achieved in 61 of 71 (85.9%) patients.ConclusionsThe primary resistance rates of H. pylori to CLA and MET in Slovenia are high. Our data strongly support the fact that in countries with high prevalence of resistant H. pylori strains susceptibility testing and tailored therapy is essential.
El miedo al fracaso: problemas de empleo juvenil en China
Authors: SCHUCHER Günter 
Published: June 2017

ResumenLos medios ofrecen datos contradictorios sobre la situación laboral de los jóvenes chinos. Las tasas de desempleo son bajas pero preocupan mucho a los dirigentes y a la población. El autor responde a esta contradicción demostrando con su examen del empleo juvenil en China que los jóvenes se quejan más del empleo inadecuado que del desempleo. En concreto, lo que preocupa a los titulados universitarios, que representan en torno a la mitad de la población joven que inicia su vida activa cada año, son las ofertas de empleo y los salarios iniciales por debajo de las expectativas y una disminución de las oportunidades de movilidad ascendente.
Prima por calificación y cambio tecnológico. Nueva evidencia sobre las manufacturas estadounidenses
Authors: MALLICK Sushanta K. , SOUSA Ricardo M. 
Published: June 2017

ResumenCon datos de la NBER‐CES Manufacturing Industry Database, los autores identifican una relación positiva entre la tecnología inferida a partir de la productividad total de los factores y las razones entre trabajadores calificados y no calificados y entre sus salarios, pero solo en sectores de base científica e intensivos en producción, mientras que es negativa en los dominados por el proveedor. Confirman la prima salarial por calificación y el aumento del sesgo tecnológico hacia el trabajo calificado desde 1980. Las diferencias de productividad entre trabajadores calificados y no calificados aumentan la demanda relativa de los primeros cuando ambos no son intercambiables. Concluyen que los gobiernos deberían promover la innovación de base científica.
Presencia sindical y prácticas de formación en el empleo. Perspectivas de Quebec
Authors: HASSI Abderrahman , FOUCHER Roland 
Published: June 2017

ResumenCon datos de una encuesta a 301 pymes de Quebec, se examina la influencia de los sindicatos en la formación en el empleo en estas empresas. Los autores se centran en la inclusión de cláusulas al respecto en convenios colectivos y concluyen que tales cláusulas establecen un marco reglamentario para ciertas medidas de fomento de la formación y el aprendizaje en el lugar de trabajo, lo que pone de relieve la influencia de los sindicatos. Sin embargo, en general la inclusión o ausencia de estas cláusulas no se traduce necesariamente en mayor o menor participación real en este tipo de actividades.
Poly‐ADP ribose polymerase‐14 limits severity of allergic skin disease
Authors: Krishnamurthy Purna , Da‐Silva‐Arnold Sonia , Turner Matthew J. , Travers Jeffrey B. , Kaplan Mark H. 
Published: June 2017

SummaryPoly‐ADP ribose polymerase‐14 (PARP14 or ARTD8) was initially identified as a transcriptional co‐activator for signal transducer and activator of transcription 6 (Stat6), where the presence of interleukin‐4 (IL‐4) and activated Stat6 induces the enzymatic activity of PARP14 that promotes T helper type 2 differentiation and allergic airway disease. To further our understanding of PARP14 in allergic disease, we studied the function of PARP14 in allergic inflammation of skin using mice that express constitutively active Stat6 in T cells (Stat6VT) and develop spontaneous inflammation of the skin. We mated Stat6VT mice to Parp14−/− mice and observed that approximately 75% of the Stat6VT × Parp14−/− mice develop severe atopic dermatitis (AD)‐like lesions, compared with about 50% of Stat6VT mice, and have increased morbidity compared with Stat6VT mice. Despite this, gene expression in the skin and the cellular infiltrates was only modestly altered by the absence of PARP14. In contrast, we saw significant changes in systemic T‐cell cytokine production. Moreover, adoptive transfer experiments demonstrated that decreases in IL‐4 production reflected a cell intrinsic role for PARP14 in Th2 cytokine control. Hence, our data suggest that although PARP14 has similar effects on T‐cell cytokine production in several allergic disease models, the outcome of those effects is distinct, depending on the target organ of disease.
Thermal phenotyping of stomatal sensitivity in spring barley
Authors: Rischbeck P. , Cardellach P. , Mistele B. , Schmidhalter U. 
Published: June 2017

AbstractThermometry and thermography are alternative methods used for measuring stomatal conductivity via transpirative cooling. However, the influence of mixed soil–plant information contained in thermal images compared to thermometric spot measurements on the measurement quality and relationships to agronomic traits remains unclear. To evaluate their respective influence, canopy temperature was measured simultaneously by two infrared thermometers (thermometry), which were oriented oblique to the plant canopy and mounted on a tractor, and a hand‐held, nadir oriented thermal camera (thermography) in irrigated and drought‐stressed spring barley cultivar trials in 2011. Canopy temperatures were separated from soil temperatures and extracted from the thermal images by matching thermal and RGB images. Thermometric measurements conducted at the beginning of shooting during a stable period of high radiation were more closely related to total plant biomass and straw yield at harvest than thermography under both irrigated and drought‐stressed conditions. Taking into account the results of this evaluation, thermometry was used for assessing the agronomic importance of stomatal sensitivity, the earliness of stomatal closure, of spring barley cultivars subjected to different water supply in 2013. In this year, 16 spring barley cultivars were grown under mild drought stress and rainfed conditions. A stomatal sensitivity index was derived relating canopy temperatures of the cultivars grown under rainfed and drought‐stressed conditions to each other. Under rainfed conditions, stomatal sensitivity was negatively related to grain protein yield with a coefficient of determination of R2 = .43. Under increasing terminal drought stress, positive regression slopes of stomatal sensitivity to grain yield, biomass yield and culms/m2 were observed with coefficients of determination amounting to R2 = .22, .31 and .36, respectively. Stomatal sensitivity negatively impacts agricultural production under well‐watered conditions, but maintains productivity under conditions of terminal drought.
Earnings quality and short selling: Evidence from real earnings management in the United States
Authors: Park KoEun 
Published: June 2017

AbstractPrior research provides evidence consistent with managers using real earnings management (REM) to increase earnings. This study examines whether short sellers exploit the overvaluation of firms employing REM. I find that firms with more REM have higher subsequent short interest. The positive relation between REM and short interest is more pronounced in settings where the costs associated with accrual‐based earnings management are high, such as when a firm has low accounting flexibility or faces greater scrutiny from a high quality auditor. I also find some evidence that short sellers respond to REM more than to other fundamental signals of firm overvaluation. My inferences are robust to the use of propensity score matching. Collectively, my evidence suggests that short sellers not only trade on REM information, but they also trade as if they understand the substitutive nature of alternative earnings management methods. This study provides additional insight into the important role that short sellers play in monitoring managerial operating decisions and overall earnings quality.
MicroRNA‐30e‐5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma
Authors: Zhuang Li , Shou Tao , Li Ke , Gao Chun‐Lin , Duan Lin‐Can , Fang Li‐Zhou , Zhang Qin‐Yong , Chen Zong‐Ning , Zhang Chao , Yang Shou‐Tao , Li Gao‐Feng 
Published: June 2017

AbstractAberrant microRNA expression is involved in the regulation of various cellular processes, such as proliferation and metastasis in multiple diseases including cancers. MicroRNA‐30e‐5p (miR‐30e) was previously reported as an oncogenic or tumour suppressing miRNA in some malignancies, but its function in lung adenocarcinoma (LAC) remains largely undefined. In this study, we found that the expression of miR‐30e was increased in LAC tissues and cell lines, associated with tumour size and represented an independent prognostic factor for overall survival and recurrence of LAC patients. Further functional experiments showed that knockdown of miR‐30e suppressed cell growth while its overexpression promoted growth of LAC cells and xenografts in vitro and in vivo. Mechanistically, PTPN13 was identified as the direct target of miR‐30e in LAC, in which PTPN13 expression was down‐regulated in LAC tissues and showed the inverse correlation with miR‐30e expression. Overexpression of PTPN13 inhibited cell growth and rescued the proliferation‐promoting effect of miR‐30e through inhibition of the EGFR signalling. Altogether, our findings suggest that miR‐30e could function as an oncogene in LAC via targeting PTPN13 and act as a potential therapeutic target for treating LAC.
A novel technique for reference point generation to aid in intraoral scan alignment
Authors: Renne Walter G. , Evans Zachary P. , Mennito Anthony , Ludlow Mark 
Published: June 2017

AbstractObjectiveWhen using a completely digital workflow on larger prosthetic cases it is often difficult to communicate to the laboratory or chairside Computer Aided Design and Computer Aided Manufacturing system the provisional prosthetic information. The problem arises when common hard tissue data points are limited or non‐existent such as in complete arch cases in which the 3D model of the complete arch provisional restorations must be aligned perfectly with the 3D model of the complete arch preparations. In these instances, soft tissue is not enough to ensure an accurate automatic or manual alignment due to a lack of well‐defined reference points. A new technique is proposed for the proper digital alignment of the 3D virtual model of the provisional prosthetic to the 3D virtual model of the prepared teeth in cases where common and coincident hard tissue data points are limited.Clinical considerations: A technique is described in which fiducial composite resin dots are temporarily placed on the intraoral keratinized tissue in strategic locations prior to final impressions. These fiducial dots provide coincident and clear 3D data points that when scanned into a digital impression allow superimposition of the 3D models.ConclusionsComposite resin dots on keratinized tissue were successful at allowing accurate merging of provisional restoration and post‐preparation 3D models for the purpose of using the provisional restorations as a guide for finalCLINICAL SIGNIFICANCEComposite resin dots placed temporarily on attached tissue were successful at allowing accurate merging of the provisional restoration 3D models to the preparation 3D models for the purposes of using the provisional restorations as a guide for final restoration design and manufacturing. In this case, they allowed precise superimposition of the 3D models made in the absence of any other hard tissue reference points, resulting in the fabrication of ideal final restorations.
Evaluation of change in dietitians’ perceived comprehensibility and difficulty of the Patient‐Generated Subjective Global Assessment (PG‐SGA) after a single training in the use of the instrument
Authors: Sealy M. J. , Ottery F. D. , van der Schans C. P. , Roodenburg J. L. N. , Jager‐Wittenaar H. 
Published: June 2017

AbstractBackgroundThe Patient‐Generated Subjective Global Assessment (PG‐SGA) is an instrument used to assess malnutrition and its risk factors. Some items of the PG‐SGA may be perceived as hard to comprehend or as difficult by healthcare professionals. The present study aimed to determine whether and how dietitians’ perceptions of comprehensibility and difficulty of the PG‐SGA change after a single training in PG‐SGA use.MethodsIn this prospective evaluation study, Dutch PG‐SGA‐naïve dietitians completed a questionnaire regarding perceived comprehensibility and difficulty of the PG‐SGA before (T0) and after (T1) receiving a single training in the use of the instrument. Perceived comprehensibility and difficulty were operationalised by calculating item and scale indices for comprehensibility (I‐CI, S‐CI) and difficulty (I‐DI, S‐DI) at T0 and T1. An item index of 0.78 was considered acceptable, a scale index of 0.80 was considered acceptable and a scale index of 0.90 was considered excellent.ResultsA total of 35 participants completed the questionnaire both at T0 and T1. All item indices related to comprehensibility and difficulty improved, although I‐DI for the items regarding food intake and physical examination remained below 0.78. Scale indices for difficulty and comprehensibility of the PG‐SGA changed significantly (P < 0.001) from not acceptable at T0 (S‐CI = 0.69; S‐DI = 0.57) to excellent for comprehensibility (S‐CI = 0.95) and acceptable for difficulty (S‐DI = 0.86) at T1.ConclusionsThe findings of the present study suggest that significant improvement in PG‐SGA‐naïve dietitians’ perception of comprehensibility and difficulty of the PG‐SGA can be achieved quickly by providing a 1 day of training in the use of the PG‐SGA.
Pontamine fast scarlet 4B bifluorescence and measurements of cellulose microfibril angles
Authors: THOMAS J. , IDRIS N.A. , COLLINGS D.A. 
Published: June 2017

SummaryPontamine fast scarlet 4B is a red paper and textiles dye that has recently been introduced as a fluorescent probe for plant cell walls. Pontamine exhibits bifluorescence, or fluorescence dependent on the polarization of the excitation light: Because cellulose is aligned within the cell wall, pontamine‐labelled cell walls exhibit variable fluorescence as the excitation polarization is modulated. Thus, bifluorescence measurements require polarized excitation that can be directly or indirectly modulated. In our confocal microscopy observations of various cellulose samples labelled with pontamine, we modulated excitation polarization either through sample rotation or by the confocal's scanfield rotation function. This variably rotated laser polarizations on Leica confocal microscopes, but not those from other makers. Beginning with samples with directly observable microfibril orientations, such as purified bacterial cellulose, the velamen of orchid roots and the inner S2 layer of radiata pine compression wood, we demonstrate that modelling the variations in pontamine fluorescence with a sine curve can be used to measure the known microfibril angles. We then measured average local microfibril angles in radiata pine samples, and showed similar microfibril angles in compression and normal (opposite) wood. Significantly, bifluorescence measurements might also be used to understand the degree of local cellulose alignment within the cell wall, as opposed to variations in the overall cellulose angle.