bluuebunny/crossref_metadata_2025_split huggingface dataset:
National Differences in Trends for Heart Failure Hospitalizations by Sex and Race/Ethnicity
Authors: Ziaeian Boback , Kominski Gerald F. , Ong Michael K. , Mays Vickie M. , Brook Robert H. , Fonarow Gregg C. 
Published: June 2017

Background—
National heart failure (HF) hospitalization rates have not been appropriately age standardized by sex or race/ethnicity. Reporting hospital utilization trends by subgroup is important for monitoring population health and developing interventions to eliminate disparities.

Methods and Results—

The National Inpatient Sample (NIS) was used to estimate the crude and age-standardized rates of HF hospitalization between 2002 and 2013 by sex and race/ethnicity. Direct standardization was used to age-standardize rates to the 2000 US standard population. Relative differences between subgroups were reported. The national age-adjusted HF hospitalization rate decreased 30.8% from 526.86 to 364.66 per 100 000 between 2002 and 2013. Although hospitalizations decreased for all subgroups, the ratio of the age-standardized rate for men compared with women increased from 20% greater to 39% (
P
trend=0.002) between 2002 and 2013. Black men had a rate that was 229% (
P
trend=0.141) and black women, 240% (
P
trend=0.725) with reference to whites in 2013 with no significant change between 2002 and 2013. Hispanic men had a rate that was 32% greater in 2002 and the difference narrowed to 4% (
P
trend=0.047) greater in 2013 relative to whites. For Hispanic women, the rate was 55% greater in 2002 and narrowed to 8% greater (
P
trend=0.004) in 2013 relative to whites. Asian/Pacific Islander men had a 27% lower rate in 2002 that improved to 43% (
P
trend=0.040) lower in 2013 relative to whites. For Asian/Pacific Islander women, the hospitalization rate was 24% lower in 2002 and improved to 43% (
P
trend=0.021) lower in 2013 relative to whites.

Conclusions—
National HF hospitalization rates have decreased steadily during the recent decade. Disparities in HF burden and hospital utilization by sex and race/ethnicity persist. Significant population health interventions are needed to reduce the HF hospitalization burden among blacks. An evaluation of factors explaining the improvements in the HF hospitalization rates among Hispanics and Asian/Pacific Islanders is needed.
Effectiveness and Safety of Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin in Patients With Nonvalvular Atrial Fibrillation and Previous Stroke or Transient Ischemic Attack
Authors: Coleman Craig I. , Peacock W. Frank , Bunz Thomas J. , Alberts Mark J. 
Published: June 2017

Background and Purpose—
Limited real-world data exist comparing each non–vitamin K antagonist oral anticoagulant (NOAC) to warfarin in patients with nonvalvular atrial fibrillation who have had a previous ischemic stroke or transient ischemic attack.

Methods—
Using MarketScan claims from January 2012 to June 2015, we identified adults newly initiated on oral anticoagulation, with ≥2 diagnosis codes for nonvalvular atrial fibrillation, a history of previous ischemic stroke/transient ischemic attack, and ≥180 days of continuous medical and prescription benefits before anticoagulation initiation. Three analyses were performed comparing 1:1 propensity score–matched cohorts of apixaban versus warfarin (n=2514), dabigatran versus warfarin (n=1962), and rivaroxaban versus warfarin (n=5208). Patients were followed until occurrence of a combined end point of ischemic stroke and intracranial hemorrhage (ICH) or major bleed, switch/discontinuation of index oral anticoagulation, insurance disenrollment, or end of follow-up. Mean follow-up was 0.5 to 0.6 years for all matched cohorts.

Results—
Using Cox regression, neither apixaban nor dabigatran reduced the combined primary end point of ischemic stroke or ICH (hazard ratio [HR], 0.70; 95% confidence interval [CI], 0.33–1.48 and HR, 0.53; 95% CI, 0.26–1.07) and had nonsignificant effect on hazards of major bleeding (HR, 0.79; 95% CI, 0.38–1.64 and HR, 0.58; 95% CI, 0.26–1.27) versus warfarin. Rivaroxaban reduced the combined end point of ischemic stroke or ICH (HR, 0.45; 95% CI, 0.29–0.72) without an effect on major bleeding (HR, 1.07; 95% CI, 0.71–1.61). ICH occurred at rates of 0.16 to 0.61 events per 100 person-years in the 3 NOAC analyses, with no significant difference for any NOAC versus warfarin.

Conclusions—
Results from our study of the 3 NOACs versus warfarin in nonvalvular atrial fibrillation patients with a previous history of stroke/transient ischemic attack are relatively consistent with their respective phase III trials and previous stroke/transient ischemic attack subgroup analyses. All NOACs seemed no worse than warfarin in respect to ischemic stroke, ICH, or major bleeding risk.
In-Patient Code Stroke
Authors: Kassardjian Charles D. , Willems Jacqueline D. , Skrabka Krystyna , Nisenbaum Rosane , Barnaby Judith , Kostyrko Pawel , Selchen Daniel , Saposnik Gustavo 
Published: June 2017

Background and Purpose—
Stroke is a relatively common and challenging condition in hospitalized patients. Previous studies have shown delays in recognition and assessment of inpatient strokes leading to poor outcomes. The goal of this quality improvement initiative was to evaluate an in-hospital code stroke algorithm and educational program aimed at reducing the response times for inpatient stroke.

Methods—
An inpatient code stroke algorithm was developed, and an educational intervention was implemented over 5 months. Data were recorded and compared between the 36-month period before and the 15-month period after the intervention was implemented. Outcome measures included time from last seen normal to initial assessment and from last seen normal to brain imaging.

Results—
During the study period, there were 218 inpatient strokes (131 before the intervention and 87 after the intervention). Inpatient strokes were more common on cardiovascular wards (45% of cases) and occurred mainly during the perioperative period (60% of cases). After implementation of an inpatient code stroke intervention and educational initiative, there were consistent reductions in all timed outcome measures (median time to initial assessment fell from 600 [109–1460] to 160 [35–630] minutes and time to computed tomographic scan fell from 925 [213–1965] to 348.5 [128–1587] minutes).

Conclusions—
Our study reveals the efficacy of an inpatient code stroke algorithm and educational intervention directed at nurses and allied health personnel to optimize the prompt management of inpatient strokes. Prompt assessment may lead to faster stroke interventions, which are associated with better outcomes.
Seeing the Way: the Role of Vision in Conversation Turn Exchange Perception
Authors: Latif Nida , Alsius Agnès , Munhall K. G. 
Published: June 2017

During conversations, we engage in turn-taking behaviour that proceeds back and forth effortlessly as we communicate. In any given day, we participate in numerous face-to-face interactions that contain social cues from our partner and we interpret these cues to rapidly identify whether it is appropriate to speak. Although the benefit provided by visual cues has been well established in several areas of communication, the use of visual information to make turn-taking decisions during conversation is unclear. Here we conducted two experiments to investigate the role of visual information in identifying conversational turn exchanges. We presented clips containing single utterances spoken by single individuals engaged in a natural conversation with another. These utterances were from either right before a turn exchange (i.e., when the current talker would finish and the other would begin) or were utterances where the same talker would continue speaking. In Experiment 1, participants were presented audiovisual, auditory-only and visual-only versions of our stimuli and identified whether a turn exchange would occur or not. We demonstrated that although participants could identify turn exchanges with unimodal information alone, they performed best in the audiovisual modality. In Experiment 2, we presented participants audiovisual turn exchanges where the talker, the listener or both were visible. We showed that participants suffered a cost at identifying turns exchanges when visual cues from the listener were not available. Overall, we demonstrate that although auditory information is sufficient for successful conversation, visual information plays an important role in the overall efficiency of communication.
Multisensory Congruency Enhances Explicit Awareness in a Sequence Learning Task
Authors: Silva Andrew E. , Barakat Brandon K. , Jimenez Luis O. , Shams Ladan 
Published: June 2017

We examined the effect of audiovisual training on learning a repeated sequence of motor responses. Participants were trained with either congruent or incongruent audiovisual cues to produce motor responses. Learning was tested by comparing reaction times to untrained sequences and by asking participants to recreate the trained sequence. A strong association was found between the two measures and the majority of high-scoring participants belonged to the congruent audiovisual condition. Because the second measure requires explicit knowledge of the trained sequence, we conclude that audiovisual congruency facilitates explicit learning.
Northern Hemisphere Jet Stream Position Indices as Diagnostic Tools for Climate and Ecosystem Dynamics
Authors: Belmecheri Soumaya , Babst Flurin , Hudson Amy R. , Betancourt Julio , Trouet Valerie 
Published: June 2017

Abstract
The latitudinal position of the Northern Hemisphere jet stream (NHJ) modulates the occurrence and frequency of extreme weather events. Precipitation anomalies in particular are associated with NHJ variability; the resulting floods and droughts can have considerable societal and economic impacts. This study develops a new climatology of the 300-hPa NHJ using a bottom-up approach based on seasonally explicit latitudinal NHJ positions. Four seasons with coherent NHJ patterns were identified (January–February, April–May, July–August, and October–November), along with 32 longitudinal sectors where the seasonal NHJ shows strong spatial coherence. These 32 longitudinal sectors were then used as NHJ position indices to examine the influence of seasonal NHJ position on the geographical distribution of NH precipitation and temperature variability and their link to atmospheric circulation pattern. The analyses show that the NHJ indices are related to broad-scale patterns in temperature and precipitation variability, in terrestrial vegetation productivity and spring phenology, and can be used as diagnostic/prognostic tools to link ecosystem and socioeconomic dynamics to upper-level atmospheric patterns.
Making Complexity Your Friend: Reframing Social Theory for the Anthropocene
Authors: Smith-Nonini Sandy 
Published: June 2017

Abstract
This article uses the dilemma of climate change as an entry point to explore the utility of a complexity framework for a more comprehensive social science of environmental sustainability. A theory of complex adaptive systems (CAS) is especially appropriate for the Anthropocene, a newly proposed geological period defined around humanity’s impact on the biosphere. Aspects of complexity theory have been entering public consciousness through popular accounts of climate “tipping points” and “emergent” change—the risk that Earth’s climate could shift into a new pattern in a relatively short time period. Social structures, including capitalism, are complex systems, as are social movements. The paper reviews CAS research with special attention to applications in social ecology. It discusses two case studies of exemplary research on human management of environmental resources and one case study of the antiglobalization movement, all conceived within a complexity framework. The central argument is that complexity thinking will enhance social studies of sustainability and efforts to create a more resilient economy and biosphere.
Newborn screening for sickle cell disorders using tandem mass spectrometry: three years’ experience of using a protocol to detect only the disease states
Authors: Moat Stuart J , Rees Derek , George Roanna S , King Lawrence , Dodd Alan , Ifederu Adeboye , Ramgoolam Tejswurree , Hillier Sharon 
Published: June 2017

Background Tandem mass spectrometry (MS/MS) has recently become an alternative method for the newborn screening of sickle cell disorders (SCD), as it is able to detect haemoglobin (Hb) peptides following digestion of bloodspots with trypsin. Using the SpOtOn Diagnostics Reagent Kit, we previously developed a screening protocol to detect only the disease states of SCD, using action values based on the ratio between the variant Hb peptide to wild-type peptide abundances for the HbS, C, DPunjab, OArab, E and Lepore peptides. Methods Action values using the ratios between the wild type HbA (ßT1-3) peptides and the foetal Hb (γT2) peptide were developed to identify bloodspot samples from premature and transfused infants. An evaluation was undertaken to assess the transferability of the action values onto an additional MS/MS instrument. We report here our experience using this MS/MS protocol. Results During a three-year period, we screened 100,456 babies and identified 10 SCD cases (1 HbS/HPFH, 5 HbS/S and 4 HbS/C) and a case of HbE/ß-thalassaemia that was identified as a by-product. The Hb variant to wild-type peptide ratio action values were transferable to a second MS/MS instrument. Our protocol prevented the identification of an estimated 810 carrier infants. Gestational age-related action values for HbA to HbF peptide ratios were required to minimize the number of samples referred for second-line testing to exclude ß-thalassaemia. Conclusion MS/MS is a robust alternative screening technology for SCD; in addition, it also optimizes the use of equipment and expertise that currently exist in newborn screening laboratories.
Bone turnover marker determinants in young women: results from the Safe-D study
Authors: Callegari Emma T , Garland Suzanne M , Gorelik Alexandra , Chiang Cherie Y , Wark John D 
Published: June 2017

Background Bone turnover markers (BTMs) may provide insight into bone health in young women, but have been little studied in this demographic. We aimed to explore the association between body composition, hormonal contraception, bone mineral density and biochemical parameters and BTMs in young women. Methods Participants were community-dwelling females aged 16–25 years, living in Victoria, Australia. Carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX) and total procollagen type 1 N-propeptide (P1NP) were analysed on the Roche Elecsys automated analyzer. A total of 305 were evaluated, after excluding participants with medical conditions or medications (except hormonal contraceptives), which may affect bone metabolism. Results Median (Q1, Q3) BTM values were 540 (410, 690) ng/L for CTX and 61.7 (46.2, 83.7) µg/L for P1NP. Serum CTX and P1NP were inversely associated with chronological age ( P < 0.001), transferrin ( P < 0.020) and serum dehydroepiandrosterone sulphate concentration ( P < 0.001). BTM values were up to 22% lower in combined oral contraceptive (COC) pill users ( P < 0.001). Serum CTX was inversely associated with per cent body fat ( P = 0.009) and tibial cortical volumetric bone mineral density (vBMD; P = 0.003). Serum P1NP concentrations were 23  µg/L higher in participants who reported using an osteopath in the previous year ( P = 0.007). Conclusions These data suggest that BTMs are influenced by age, COC use, body composition, iron status and hormonal profiles. Higher CTX values were associated with lower tibial cortical vBMD. Examining BTMs in relation to interventions aimed at improving bone health in young women is warranted.
Coercive Inclusion in the Mexican War on Drugs: A Field Study of Human Rights and the State in Michoacán
Authors: Wolfesberger Philipp 
Published: June 2017

Qualitative ethnographic study of the human rights violations committed in the course of the militarized combat against drug trafficking organizations in rural Michoacán unmasks state practices of coercive inclusion. The violation of human rights and the subsequent processing of human rights claims paradoxically bind the marginalized population to the formal state and foster its subordination. The practical configuration of the current arena of human rights is not the lever for a democratic, inclusive Mexico but a curtain that conceals the repressive practices that it makes possible. In the processing of human rights complaints, the legal rights of physical integrity and private property become moral rights with no effect of legal justice. Un estudio etnográfico cualitativo sobre las violaciones a los derechos humanos cometidas durante la lucha militarizada contra las organizaciones de tráfico de drogas en el Michoacán rural sirve para desenmascarar las prácticas de inclusión coercitiva del Estado. Las violaciones y el posterior procesamiento de las denuncias paradójicamente vinculan a la población marginada con el Estado oficial, fomentando su subordinación. La configuración práctica del actual contexto de los derechos humanos no funge como la palanca de un México democrático e inclusivo, sino como una cortina que oculta las prácticas represivas que el Estado hace posibles. En la tramitación de las denuncias sobre violación de derechos humanos, los derechos legales de la integridad física y la propiedad privada se convierten en derechos morales sin ningún efecto de justicia legal.
Successful Return to Sport After Arthroscopic Shoulder Stabilization Versus Nonoperative Management in Contact Athletes With Anterior Shoulder Instability: A Prospective Multicenter Study
Authors: Dickens Jonathan F. , Rue John-Paul , Cameron Kenneth L. , Tokish John M. , Peck Karen Y. , Allred C. Dain , Svoboda Steven J. , Sullivan Robert , Kilcoyne Kelly G. , Owens Brett D. 
Published: June 2017

Background: The debate continues regarding the optimal treatment of intercollegiate contact athletes with in-season anterior shoulder instability. Purpose: To examine return to sport and recurrent instability in the season after the index in-season anterior instability event. Study Design: Cohort study; Level of evidence, 2. Methods: Forty-five contact intercollegiate athletes treated nonoperatively or with arthroscopic stabilization were prospectively followed in a multicenter observational study to evaluate return to play (RTP) and recurrent instability in the season after an initial in-season anterior glenohumeral instability event. Baseline data collection included sport played, previous instability events, direction of instability, type of instability (subluxation or dislocation), and treatment method (nonoperative management or arthroscopic stabilization). All nonoperatively treated athletes underwent a standardized accelerated rehabilitation program without shoulder immobilization. Surgical stabilization was performed arthroscopically in all cases, and successful RTP was evaluated during the next competitive season after complete rehabilitation. Results: Thirty-nine of 45 intercollegiate contact athletes had remaining National Collegiate Athletic Association eligibility and were followed through the subsequent competitive season after the index instability event. Of the 10 athletes electing nonoperative treatment, 4 (40%) successfully returned to play without recurrence during the subsequent season. Of the 29 athletes treated surgically, 26 (90%) were able to successfully return to play without recurrence the following season (recurrence: n = 1; inadequate function: n = 2). Athletes who underwent surgical reconstruction before the next season were 5.8 times (95% CI, 1.77-18.97; P = .004) more likely to complete the subsequent season without recurrent instability. Of the 29 athletes electing surgical stabilization, there was no difference (risk ratio, 0.95; 95% CI, 0.10-9.24; P > .99) in RTP between the 9 stabilized after a single instability event (90% RTP rate) and the 20 stabilized after multiple in-season recurrent instability events (89% RTP rate). Conclusion: Collegiate contact and collision athletes with in-season anterior shoulder instability are significantly more likely to successfully return to sport without subsequent instability events the next season if they undergo surgical repair in the off-season.
Relationship between treatment of erectile dysfunction and future risk of cardiovascular disease: A nationwide cohort study
Authors: Vestergaard Nanna , Søgaard Peter , Torp-Pedersen Christian , Aasbjerg Kristian 
Published: June 2017

Abstract

Aims
Erectile dysfunction is associated with increased risk of cardiovascular disease; however, little is known about patients seeking treatment for erectile dysfunction. This study investigated the risk of cardiovascular disease for patients receiving medication for erectile dysfunction.

Methods and results
This nationwide cohort study included 71,710 men aged 40–80 years receiving their first erectile dysfunction medication from 2000 to 2012. Their adjusted risk of cardiovascular events in time intervals after the first erectile dysfunction medication was compared to the general male population using multivariate Poisson regression models and was expressed as a risk ratio (RR). The risk for overall cardiovascular disease was decreased in the first 3 years: the RR in the first year was 0.92 (95% confidence interval [CI] 0.87–0.97, p = 0.003; incidence: 23.68 per 1000 patient-years), and after 1–3 years the RR was 0.94 (95% CI 0.90–0.97, p = 0.002; incidence: 24.92 per 1000 patient-years). After 3 years, there was no significant difference. The risk of myocardial infarction was decreased in all time intervals: the RR in the first year was 0.60 (95% CI 0.50–0.73, p &lt; 0.001; incidence: 1.82 per 1000 patient-years), after 1–3 years the RR was 0.72 (95% CI 0.63–0.82, p &lt; 0.001; incidence: 2.16 per 1000 patient-years) and after 3 years the RR was 0.80 (95% CI 0.73–0.88, p &lt; 0.001; incidence: 2.25 per 1000 patient-years). The risk of heart failure was decreased in the first 3 years.

Conclusion
Receiving medication for erectile dysfunction was associated with a decreased risk of myocardial infarction and cardiovascular diseases for the first 3 years.
Is minimally invasive surgery superior to open surgery for treatment of lumbar spinal stenosis? A systematic review
Authors: Ka Man Ng Karen , Pui Yin Cheung Jason 
Published: June 2017

Purpose: The purpose of this study is to review the updated evidence comparing outcomes between minimally invasive surgery (MIS) and conventional open surgery (COS) for lumbar spinal stenosis (LSS). Methods: All randomized controlled trials (RCTs) published from January 2005 to August 2016 were identified through PubMed and MEDLINE databases. Only RCTs including patients with LSS and with direct comparison between COS and MIS were selected for analysis. The intra- and post-operative effects of different MIS and COS on patients with LSS were evaluated for any differences. Results: We reviewed 10 RCTs comparing the effect of MIS and COS for LSS. Most trials showed that MIS rendered a shorter duration of hospital stay, lower reoperation rate, visual analogue scale (VAS), 36-Item Form Health Survey (SF-36) score, creatinine phosphokinase-skeletal muscle (CPK-MM) levels and a higher Japanese Orthopaedic Association (JOA) score. However, the intergroup differences were not statistically significant for all comparisons and were only present for selected mild cases of spinal stenosis. Conclusions: This systematic review suggests that MIS reduces operating time, duration of hospital stay and CPK-MM levels. However, the evidence for these parameters is weak. Moreover, there is no conclusive evidence that MIS reduces reoperation or has better improvement in pain and outcome scores like VAS, SF-36 and JOA scores. The evidence is limited due to poor standardization of MIS definition, methodology and details of surgeon experience. MIS techniques should not be studied as a group, as each procedure is vastly different from each other.