bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of makerspace health and student tool usage during and after the COVID-19 pandemic
Authors: Kaat Claire , Blair Samuel , Layton Astrid , Linsey Julie 
Published: September 2024

Abstract
Prior research emphasizes the benefits of university makerspaces, but overall, quantitative metrics to measure how a makerspace is doing have not been available. Drawing on an analogy to metrics used for the health of industrial ecosystems, this article evaluates changes during and after COVID-19 for two makerspaces. The COVID-19 pandemic disturbed normal life worldwide and campuses were closed. When students returned, campus life looked different, and COVID-19-related restrictions changed frequently. This study uses online surveys distributed to two university makerspaces with different restrictions. Building from the analysis of industrial ecosystems, the data were used to create bipartite network models with students and tools as the two interacting actor groups. Modularity, nestedness and connectance metrics, which are frequently used in ecology for mutualistic ecosystems, quantified the changing usage patterns. This unique approach provides quantitative benchmarks to measure and compare makerspaces. The two makerspaces were found to have responded very differently to the disruption, though both saw a decline in overall usage and impact on students and the space’s health and had different recoveries. Network analysis is shown to be a valuable method to evaluate the functionality of makerspaces and identify if and how much they change, potentially serving as indicators of unseen issues.
On the factors influencing confidence in models and simulations for decision-making: a survey
Authors: Schwarzburg Johannes , Trauer Jakob , Rebentisch Eric 
Published: September 2024

Abstract
Over the last decades, modeling and simulation have become central methods in engineering design. Today’s technologies enable previously unachievable levels of sophistication and accuracy. However, if decision-makers are unaware of the confidence they can place in models and simulations (M&S), they either fail to leverage their potential by not involving them in processes or make judgments based on unreliable results. Assessments to evaluate M&S exist, but factors that enable decision-makers to have confidence and improve acceptance of using M&S need to be researched in more detail. Therefore, a literature review analyzing design requirements and an online survey to measure factors associated with confidence were conducted. As a result, the survey identified nine predictors of confidence: (1) capability, (2) history, (3) validity, (4) reliability and (5) accessibility of the model. Further, (6) integrity and (7) competence of the modeler, as well as (8) trusting nature and (9) risk awareness of the stakeholder were identified. Having confidence in M&S results significantly increases the reliance on them and leads to better-informed decision-making. Therefore, based on the findings, a framework and an initial application model were developed. The results were initially evaluated and are described.
Large herbivore δ18O as a proxy for aridity in the South African winter and year-round rainfall zone
Authors: Luyt Julie , Faith J. Tyler , Sealy Judith 
Published: September 2024

AbstractThis study explores patterning in δ18O values of tooth enamel in contemporary African herbivores from mainly C3-dominated ecosystems. Evapotranspiration causes plants to lose H216O to a greater extent than H218O, leaving leaves enriched in 18O. In eastern Africa, ES species (evaporation-sensitive species: those obtaining water from food) tend to have more positive δ18Oenamel values than EI species (evaporation-insensitive species: those heavily dependent on drinking water); the magnitude of the difference increases with increasing aridity. We find the same pattern applies in the winter and year-round rainfall region of southern Africa, allowing us to use δ18Oenamel in fossil animals to examine paleo-aridity. We apply this approach to infer aridity at Quaternary fossil assemblages from present-day winter and year-round rainfall zones, including Elandsfontein (ca. 1–0.6 Ma), Hoedjiespunt (ca. 300–130 ka), and Nelson Bay Cave (23.5–3 ka). This analysis suggests that (1) at various times during the Pleistocene, Elandsfontein and Hoedjiespunt environments were wetter than last glacial maximum (LGM) to Holocene environments at Nelson Bay Cave (year-round rainfall zone); and (2) considered alongside other evidence from the year-round rainfall zone, wetter conditions across the Pleistocene–Holocene transition at Nelson Bay Cave suggests that climate changes at near-coastal sites may be out of phase with the adjacent interior.
Christian Humanism
Authors: Fransen Peter 
Published: September 2024

'Therefore, if anyone is in Christ, he is a new creature; the old has
passed away, behold, the new has come’ (2 Cor. 5.17). ‘Neither circumcision
or lack of circumcision means anything, but a new creation’ (Gal. 6. 15).
Such is St Paul's clear teaching.
The life of a Christian is a new life, a new life in Christ and in the
Spirit. We find this divine promise of a newness of life even in the Old
Testament, in prophecies which can be said to have announced the mysteries
of God's grace in a unique way. In Ezekiel God tells us about the last
times, the days of Yahweh, the days in which he will manifest his glory,
that is, his living presence among us in this world of ours, the days of the
redemption in Christ. ‘Cast away from you all your transgressions, and make
yourselves a new heart and a new spirit’ (Ez. 18.31).
Love Among The Saints
Authors: Vann Gerald 
Published: September 2024

Nature abhors a vacuum: and terrible things can happen to a man with an
empty heart. That is one reason why it can be more difficult for a priest or
a religious to be a good Christian, living a really vital Christian life,
than for happily-married lay people. The latter can without too much
difficulty integrate their love of each other into their shared love of God,
sanctifying the one and deepening the other. What of the priest and the
religious?
One sometimes meets among lay people a dangerously romanticised idea of
this vocation. For them, these are men and women set apart, dedicated,
living in the sanctuary, their whole lives are spent close to God, their
minds and hearts filled with God, and with a charity which causes them to
think of all other human beings as ‘souls’ to be served and saved. And to
move the more sentimental, there is that appalling painting of the young
monk with cowled head gazing wistfully through the narrow gothic windows of
his tiny cell at the world he has lost for ever…
Charles de Foucauld: Thirty Years Afterwards
Authors: Sheppard Lancelot C. 
Published: September 2024

Charles de Foucauld’s silent death at Tamanrasset on December 1st, 1916,
was the crowning proof, in a life full of them, of the falsity of that
remark of an Arab’s to Ernest Paichari: Oui, vous autres
français, vous avez le royaume de la terre; nous, les Maures, nous avons
le royaume du ciel. The kingdom of heaven was surely
opened to this Frenchman who had lived prepared for such a death; for in one
of his notebooks, found after his death, was discovered this sentence,
written at the head of the page: Vivre comme si tu devain
mourir martyr aujourd’hui.
His life is too well known for it to be recounted once again; but it is
useful for many reasons to attempt an estimate of the influence of that
life, and to try and fathom to some degree Père Charles’s intentions and
motives, to seek, even, an interpretation of that living martyrdom that was
his life.
He died to all outward seeming a failure; yet how often is that. the lot
of the saints. His diaries, his letters, all record his great desire for
some companions to share his solitude.
The Mariology of Polish Christmas Carols
Authors: Wisniewsky Julien 
Published: September 2024

Our Lady has a prominent place in the mystery of the Incarnation. The
time when the Church celebrates this mystery, that is, Christmastide—Advent,
Christmas, Epiphany—is a sort of prolonged feast of Mary. No wonder that her
place in Christmas carols and especially in Polish ones is
outstanding.
The Blessed Trinity: The significance of our
Lady can only be fully understood if it is viewed from the most fundamental
truth, namely, the Blessed Trinity ‘from whom all things proceed”.
In the Polish carols there is full awareness of this fact:

I believe in one God in heaven
The Father who created this world for
himself
And in Jesus his Son,
In all things equal to the Father
Our Lord.
He desiring to save our human race
From the high heaven descended on
earth
And was conceived of the Holy Ghost
Is born among beasts
From the maiden Mary…

This carol, which seems to be the Creed specially arranged for
Christmastide, gives the proper setting for the whole problem. It introduces
the right order. But it does not exhaust all the ways in which this truth is
presented.
Total Magnetic Field Perturbations at Martian Low Altitudes (≤500 km): MAVEN Observations in 2014–2023
Authors: Park Jaeheung 
Published: September 2024

AbstractMagnetic perturbations in the Martian ionosphere are often considered as representing plasma irregularities, but thorough statistical comparisons between the two independent phenomena have been rarely conducted. In this study, we investigate the statistical relationship between total magnetic field perturbations and those of O2+ density as observed by the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft at altitudes below 500 km in 2014–2023. From the 1 Hz time series of magnetic field strength, perturbation intensity is estimated by subtracting a signal smoothed with a Savitzky‐Golay filter (window size ∼36 km). Statistically, the magnetic perturbations are stronger on the dayside than at night, in the local summer hemisphere than in winter, and away from crustal magnetic anomalies than nearby. Also, day‐to‐day variability of the magnetic perturbations exhibits a weak but significant correlation with that of solar wind electron density. The statistical behavior of total magnetic field perturbations is not the same as that of O2+ density perturbations: that is, the former is not a perfect proxy for the latter. The seemingly counter‐intuitive discrepancy can be explained by effects of inhomogeneous background magnetic field strength (participating in total pressure balance across plasma perturbations) and localized ionospheric currents at altitudes unreachable by MAVEN.
Potent combination benefit of the AKT inhibitor capivasertib and the BCL-2 inhibitor venetoclax in diffuse large B cell lymphoma
Authors: Willis Brandon S. , Mongeon Kevin , Dry Hannah , Neveras India L. , Bryan Nadezda , Pandya Meghana , Roderick-Richardson Justine , Xu Wendan , Yang Li , Rosen Alan , Reimer Corinne , Tuskova Liliana , Klener Pavel , Mettetal Jerome T. , Lenz Georg , Barry Simon T. 
Published: September 2024

AbstractThe therapeutic potential of targeting PI3K/AKT/PTEN signalling in B-cell malignancies remains attractive. Whilst PI3K-α/δ inhibitors demonstrate clinical benefit in certain B-cell lymphomas, PI3K signalling inhibitors have been inadequate in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) in part, due to treatment related toxicities. Clinically, AKT inhibitors exhibit a differentiated tolerability profile offering an alternative approach for treating patients with B-cell malignancies. To explore how AKT inhibition complements other potential therapeutics in the treatment of DLBCL patients, an in vitro combination screen was conducted across a panel of DLCBL cell lines. The AKT inhibitor, capivasertib, in combination with the BCL-2 inhibitor, venetoclax, produced notable therapeutic benefit in preclinical models of DLBCL. Capivasertib and venetoclax rapidly induced caspase and PARP cleavage in GCB-DLBCL PTEN wildtype cell lines and those harbouring PTEN mutations or reduced PTEN protein, driving prolonged tumour growth inhibition in DLBCL cell line and patient derived xenograft lymphoma models. The addition of the rituximab further deepened the durability of capivasertib and venetoclax responses in a RCHOP refractory DLBCL in vivo models. These findings provide preclinical evidence for the rational treatment combination of AKT and BCL-2 inhibitors using capivasertib and venetoclax respectively alongside anti-CD20 antibody supplementation for treatment of patients with DLBCL.
Comparison between AH plus sealer and total fill bioceramic sealer performance in previously untreated and retreatment cases of maxillary incisors with large-sized periapical lesion: a randomized controlled trial
Authors: Wahbi Eisa , Achour Hassan , Alsayed Tolibah Yasser 
Published: September 2024

Abstract
Objective
This study aims to assess the efficacy of bioceramic (BC) sealer when applied using the single cone technique (SCT), in comparison to AH Plus sealer applied with the cold lateral condensation technique (LCT), concerning their impact on the healing of large-sized periapical lesions in both untreated and retreatment cases.

Materials and methods
A randomized controlled trial was conducted on 41 patients who had 60 permanent teeth in the maxillary incisors that were accompanied by large-sized periapical lesions. The included teeth were radiographed with cone beam computed tomography (CBCT) images and divided equally into two groups according to the endodontic treatment statute (30 untreated previous cases and 30 retreated cases). Subsequently, teeth received uniform preparation, irrigation, and dressing procedures. Then each group was divided equally according to the used sealer (15 teeth obturated using AH plus sealer with LCT and 15 teeth obturated using BC sealer with SCT). All cases were followed up after 6 and 12 months with CBCT images. Subsequently, the change in periapical lesion diameter (PLD) was observed as an indicator to determine the treatment outcome score. One-way ANOVA and Mann–Whitney U test were used to analyze the PLD changing and scoring the treatment outcome during the follow-up periods. The significance level was set at α = 0.05.

Results
There were no statistically significant differences between untreated and retreatment cases neither using AH plus sealer with LCT nor BC sealer with SCT regarding changes in PLD in the follow-up periods. Moreover, there were no significant differences between groups regarding treatment outcome scores in the follow-up periods. All groups showed a high success rate.

Conclusions
Successful treatment was achieved for untreated or retreatment maxillary incisor cases accompanied by large-sized periapical lesions using either BC sealer with the SCT or AH Plus sealer with LCT with a similar high success rate up to 12 months follow-up period.
Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions
Authors: Saito Kiyoka , van der Garde Mark , Umemoto Terumasa , Miharada Natsumi , Sjöberg Julia , Sigurdsson Valgardur , Shirozu Haruki , Kamei Shunsuke , Radulovic Visnja , Suzuki Mitsuyoshi , Nakano Satoshi , Lang Stefan , Hansson Jenny , Olsson Martin L. , Minami Takashi , Gouras Gunnar , Flygare Johan , Miharada Kenichi 
Published: September 2024

AbstractHematopoietic stem cells (HSCs) react to various stress conditions. However, it is unclear whether and how HSCs respond to severe anemia. Here, we demonstrate that upon induction of acute anemia, HSCs rapidly proliferate and enhance their erythroid differentiation potential. In severe anemia, lipoprotein profiles largely change and the concentration of ApoE increases. In HSCs, transcription levels of lipid metabolism-related genes, such as very low-density lipoprotein receptor (Vldlr), are upregulated. Stimulation of HSCs with ApoE enhances their erythroid potential, whereas HSCs in Apoe knockout mice do not respond to anemia induction. VldlrhighHSCs show higher erythroid potential, which is enhanced after acute anemia induction. VldlrhighHSCs are epigenetically distinct because of their low chromatin accessibility, and more chromatin regions are closed upon acute anemia induction. Chromatin regions closed upon acute anemia induction are mainly binding sites of Erg. Inhibition of Erg enhanced the erythroid differentiation potential of HSCs. Our findings indicate that lipoprotein metabolism plays an important role in HSC regulation under severe anemic conditions.
3D printed Ti3C2@Polymer based artificial forest for autonomous water harvesting system
Authors: Vaghasiya Jayraj V. , Sonigara Keval K. , Mayorga-Martinez Carmen C. , Pumera Martin 
Published: September 2024

AbstractThe escalating scarcity of freshwater resources presents significant challenges to global sustainability, demanding innovative solutions by integrating cutting-edge materials and technologies. Here we introduce an autonomous artificial forest (3D AF) for continuous freshwater acquisition. This system features a three-dimensional (3D) architecture incorporating a carbon nanofiber (CNF) network and MXene@polypyrrole (Ti3C2@PPy), enhancing surface area, light absorption, heat distribution, and surface wettability to improve solar vapor generation and fog collection efficiency. The autonomous operation is facilitated by an integrated photothermal actuator that adjusts to the day and night conditions. During daylight, the 3D AF tilts downward to maximize solar exposure for water evaporation, while at night, it self-adjusts to optimize fog particle collection. Notably, our device demonstrates the ability to harvest over 5.5 L m−2 of freshwater daily outdoors. This study showcases the potential of integrating advanced materials and technologies to address pressing global freshwater challenges, paving the way for future innovations in water harvesting.
Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics
Authors: Lok Si , Lau Timothy N. H. , Trost Brett , Tong Amy H. Y. , Paton Tara , Wintle Richard F. , Engstrom Mark D. , Gunn Anne , Scherer Stephen W. 
Published: September 2024

AbstractThe muskox (Ovibos moschatus), an integral component and iconic symbol of arctic biocultural diversity, is under threat by rapid environmental disruptions from climate change. We report a chromosomal-level haploid genome assembly of a muskox from Banks Island in the Canadian Arctic Archipelago. The assembly has a contig N50 of 44.7 Mbp, a scaffold N50 of 112.3 Mbp, a complete representation (100%) of the BUSCO v5.2.2 set of 9225 mammalian marker genes and is anchored to the 24 chromosomes of the muskox. Tabulation of heterozygous single nucleotide variants in our specimen revealed a very low level of genetic diversity, which is consistent with recent reports of the muskox having the lowest genome-wide heterozygosity among the ungulates. While muskox populations are currently showing no overt signs of inbreeding depression, environmental disruptions are expected to strain the genomic resilience of the species. One notable impact of rapid climate change in the Arctic is the spread of emerging infectious and parasitic diseases in the muskox, as exemplified by the range expansion of muskox lungworms, and the recent fatal outbreaks of Erysipelothrix rhusiopathiae, a pathogen normally associated with domestic swine and poultry. As a genomics resource for conservation management of the muskox against existing and emerging disease modalities, we annotated the genes of the major histocompatibility complex on chromosome 2 and performed an initial assessment of the genetic diversity of this complex. This resource is further supported by the annotation of the principal genes of the innate immunity system, genes that are rapidly evolving and under positive selection in the muskox, genes associated with environmental adaptations, and the genes associated with socioeconomic benefits for Arctic communities such as wool (qiviut) attributes. These annotations will benefit muskox management and conservation.
Progressive cervical cord atrophy parallels cognitive decline in Alzheimer’s disease
Authors: Emmenegger Tim M. , Seiler Raoul , Unschuld Paul G. , Freund Patrick , Klohs Jan ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: September 2024

AbstractAlzheimer’s disease (AD) is characterized by progressive episodic memory dysfunction. A prominent hallmark of AD is gradual brain atrophy. Despite extensive research on brain pathology, the understanding of spinal cord pathology in AD and its association with cognitive decline remains understudied. We analyzed serial magnetic resonance imaging (MRI) scans from the ADNI data repository to assess whether progressive cord atrophy is associated with clinical worsening. Cervical cord morphometry was measured in 45 patients and 49 cognitively normal controls (CN) at two time points over 1.5 years. Regression analysis examined associations between cord atrophy rate and cognitive worsening. Cognitive and functional activity performance declined in patients during follow-up. Compared with controls, patients showed a greater rate of decline of the anterior–posterior width of the cross-sectional cord area per month (− 0.12%, p = 0.036). Worsening in the mini-mental state examination (MMSE), clinical dementia rating (CDR), and functional assessment questionnaire (FAQ) was associated with faster rates of cord atrophy (MMSE: r = 0.320, p = 0.037; CDR: r = − 0.361, p = 0.017; FAQ: r = − 0.398, p = 0.029). Progressive cord atrophy occurs in AD patients; its rate over time being associated with cognitive and functional activity decline.
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro
Authors: Harracksingh Alicia N. , Singh Anhadvir , Mayorova Tatiana D. , Bejoy Brian , Hornbeck Jillian , Elkhatib Wassim , McEdwards Gregor , Gauberg Julia , Taha Abdul , Islam Ishrat Maliha , Erclik Ted , Currie Mark A. , Noyes Marcus , Senatore Adriano 
Published: September 2024

AbstractPDZ domain mediated interactions with voltage-gated calcium (CaV) channel C-termini play important roles in localizing membrane Ca2+ signaling. The first such interaction was described between the scaffolding protein Mint-1 and CaV2.2 in mammals. In this study, we show through various in silico analyses that Mint is an animal-specific gene with a highly divergent N-terminus but a strongly conserved C-terminus comprised of a phosphotyrosine binding domain, two tandem PDZ domains (PDZ-1 and PDZ-2), and a C-terminal auto-inhibitory element that binds and inhibits PDZ-1. In addition to CaV2 chanels, most genes that interact with Mint are also deeply conserved including amyloid precursor proteins, presenilins, neurexin, and CASK and Veli which form a tripartite complex with Mint in bilaterians. Through yeast and bacterial 2-hybrid experiments, we show that Mint and CaV2 channels from cnidarians and placozoans interact in vitro, and in situ hybridization revealed co-expression in dissociated neurons from the cnidarian Nematostella vectensis. Unexpectedly, the Mint orthologue from the ctenophore Hormiphora californiensis strongly bound the divergent C-terminal ligands of cnidarian and placozoan CaV2 channels, despite neither the ctenophore Mint, nor the placozoan and cnidarian orthologues, binding the ctenophore CaV2 channel C-terminus. Altogether, our analyses suggest that the capacity of Mint to bind CaV2 channels predates bilaterian animals, and that evolutionary changes in CaV2 channel C-terminal sequences resulted in altered binding modalities with Mint.