bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Stable Copper Nanoparticles Linked to Organic Frameworks as Recyclable Catalyst for Three‐Component Click Cycloaddition in Water
Authors: Prakash Sadasivan P. , Gopidas Karical R. 
Published: September 2016

AbstractSynthesis, characterization and catalytic applications of highly stable copper‐nanoparticles linked to aromatic frameworks are reported. Synthesis of these nanoparticles was achieved in a one‐pot reaction which involved the simultaneous reduction of CuCl2.2H2O and 4,4’‐biphenylene‐bis‐diazonium tetrafluoroborate using sodium borohydride. Copper atoms formed upon reduction of Cu ions undergo clustering, leading to the formation of copper nanoparticles. At the same time, 4,4’‐biphenylene‐bis‐diazonium tetrafluoroborate are converted to biphenylene biradicals, which undergoes rapid addition reactions with each other and also on to the nanoparticle surfaces resulting in the formation of aromatic framework linked Cu nanoparticles. Four different types of nanoparticles were prepared by varying the concentration of the metal salts and the ligands. The structure and morphology of these materials were studied using XRD, XPS, SEM and HRTEM analysis. The materials were found to be very good catalysts for click reactions between azides and alkynes and exhibited TOF values as high as 305400 h−1. They also efficiently catalyzed the one‐pot click reactions involving azide precursors, sodium azide and alkyne. TOF up to 99000 h−1 were observed for these reactions.
Propionibacterium acnes Host Inflammatory Response During Periprosthetic Infection Is Joint Specific
Authors: Nodzo Scott R. , Boyle K. Keely , Bhimani Samrath , Duquin Thomas R. , Miller Andy O. , Westrich Geoffrey H. 
Published: September 2016

Background Propionibacterium acnes ( P. acnes) has become increasingly recognized as a cause of periprosthetic joint infection (PJI). Questions/Purposes It is not currently known if the clinical presentation of P. acnes varies depending on the joint being infected. Methods We retrospectively reviewed patients infected with P. acnes after total hip, knee, and shoulder arthroplasty from two institutions. Patients were classified as having a PJI based on the Musculoskeletal Infection Society criteria and were excluded if they had a polymicrobial culture. Patient demographics, preoperative laboratory values, and microbiology data were analyzed. Results Eighteen knees, 12 hips, and 35 shoulders with a P. acnes PJI were identified. Median ESR was significantly higher in the knee (38.0 mm/h, IQR 18.0–58.0) and hip (33.5 mm/h, IQR 15.3–60.0) groups compared to the shoulder group (11.0 mm/h, IQR 4.5–30.5). C-reactive protein levels were higher in the knee (2.0 mg/dl, IQR 1.3–8.9) and hip (2.4 mg/dl, IQR 0.8–4.9) groups compared to the shoulder group (0.7 mg/dl, IQR 0.6–1.5). Median synovial fluid WBC was significantly higher in the knee group than shoulder group (19, 950 cells/mm3, IQR 482–60, 063 vs 750 cells/mm3, IQR 0–2825, respectively). Peripheral blood WBC levels were similar between groups, as was mean time of P. acnes growth in culture. Clindamycin resistance was present in all groups. Conclusion The manner in which a patient with P. acnes PJI presents is joint specific. Inflammatory markers were significantly higher in the knee and hip groups compared to the hip and shoulder groups, and long hold anaerobic cultures up to 14 days are necessary to accurately identify this organism.
Robust Flash Calculation Algorithm for Microemulsion Phase Behavior
Authors: Khorsandi Saeid , Johns Russell T. 
Published: September 2016

AbstractThe HLD‐NAC model was recently modified to match and predict microemulsion phase behavior experimental data for Winsor type III regions. Until now, the HLD‐NAC model could not generate realistic phase behavior for type II− and type II+ two‐phase regions, leading to significant saturation and composition discontinuities when catastrophe theory is applied. These discontinuities lead to significant failures in modeling surfactant applications. We modify the HLD‐NAC equations to ensure consistency over the entire composition space including type II− and II+ regions. A robust and efficient algorithm is developed that always converges and provides continuous estimates with any formation variable of tie lines and triangles for all Winsor types. Discontinuities are eliminated and limiting tie lines near critical points are determined analytically. The tuning procedure is demonstrated using several sets of experimental data. Excellent predictability of tie lines and tie triangles, and solubilization ratios are shown.
Metal‐Catalyzed Alkene Functionalization Reactions Towards Production of Detergent and Surfactant Feedstocks
Authors: Alam Mohd. Gulfam , Tshabalala Thandeka A. , Ojwach Stephen O. 
Published: September 2016

AbstractMetal complexes have been used as catalysts in alkene transformation reactions to produce alcohols, esters, and organic acids as potential raw materials for the manufacture of detergents, perfumes, and other fine chemicals. Herein, we report the use of palladium(II) and ruthenium complexes as efficient catalyst precursors for the methoxycarbonylation, hydrogenolysis, and ethoxylation reactions of higher alkenes. The palladium catalysts showed high chemoselectivity (>98 %) and regioselectivities of about 40 % towards the formation of esters and branched isomers, respectively. Subsequent hydrogenolysis of the esters to the corresponding alcohols was achieved using ruthenium catalysts. Reactions of the esters and alcohols with ethylene oxide using calcinated aluminum oxide catalysts produced the corresponding alcohol and methyl ester ethoxylates, respectively. The identity of the phosphine derivatives, catalyst loading, reaction time, temperature, and pressure were found to influence the catalytic activity and regioselectivity of the complexes.
Productivity, Rank, and Returns in Polygamy
Authors: Matz Julia Anna 
Published: September 2016

Abstract
This study sheds light on the development of family structures in a polygamous context with a particular emphasis on wife order, and offers an explanation for the association between outcomes of children and the status of their mothers among wives based on observable maternal characteristics. In a simple framework, I propose that selection into rank among wives with respect to female productivity takes place: highly productive women are more strongly demanded in the marriage market than less productive women, giving them a higher chance of becoming first wives. Furthermore, productivity is positively associated with a wife’s bargained share of family income to be spent on consumption and investment for herself and her offspring because of greater contributions to family income and larger outside options. The findings are empirically supported by a positive relationship between indicators of female productivity and women’s levels of seniority among wives, and by a concise replication of existing evidence relating wife order to children’s educational outcomes in household survey data from rural Ethiopia.
Patient Discussion About Sexual Health with Health Care Providers After Cancer—A National Survey
Authors: Ben Charif Ali , Bouhnik Anne-Déborah , Courbiere Blandine , Rey Dominique , Préau Marie , Bendiane Marc-Karim , Peretti-Watel Patrick , Mancini Julien 
Published: September 2016

ABSTRACTIntroductionA discussion about sexuality should become a routine part of the personalized care pathway for patients with cancer.AimTo assess rates of patient discussion about sexuality with health care providers after cancer.MethodsWe used data from the representative French nationwide 2012 VICAN survey, which included 4,349 adults 18 to 82 years old who were still alive 2 years after diagnosis at 12 cancer sites.Main Outcome MeasuresSelf-reported rates of discussion about sexuality with health care providers were assessed, and associated factors were tested after systematic adjustment for a sexual health indicator (created from six items of the Relationship and Sexuality Scale).ResultsOf 4,181 respondents to the question on a discussion about sexuality, 54.7% reported that nobody had proposed a discussion to them, 21.9% did not want any discussion, and 23.4% had had a discussion. Women had less discussion about sexuality with health care providers (11.1% vs 36.7% of men, P &lt; .001) and were more likely to request a discussion at their own initiative (62.9% vs 48.0% of men, P &lt; .001). Discussion about sexuality was more frequent with patients with prostate (56.3%) and cervical (39.6%) cancer, but increasing age was associated with a greater reluctance to discuss this issue (odds ratio = 1.17, 95% CI = 1.04–1.2). The likelihood of discussion increased with severe sexual problems, radiotherapy, general sequelae, having an information-seeker profile, previous professional psychological help, and initial treatment in private centers. Patients initially wishing for psychological help were more likely to desire a discussion about sexuality.ConclusionSexuality receives little attention in French patients with cancer. Inequalities in the discussion about sexuality were observed in relation to the type of care center where the patient was initially managed. Information on supportive interventions, including more systematic referral for professional psychological help, should be developed to facilitate discussion and should be offered to all patients, irrespective of severity of sexual problems, age, sex, cancer site, and care center.
Reperfusion treatment delays amongst patients with painless ST segment elevation myocardial infarction
Authors: Pek Pin Pin , Loy En Yun , Wah Win , Ho Andrew Fu Wah , Zheng Huili , Fook-Chong Stephanie Man Chung , Chua Terrance Siang Jin , Koh Tian Hai , Chow Khuan Yew , Liu Nan , Ong Marcus Eng Hock 
Published: September 2016

AbstractObjectiveEarly reperfusion therapy in the treatment of ST segment elevation myocardial infarction (STEMI) patients can improve outcomes. Silent myocardial infarction is associated with poor prognosis, but little is known about its effect on treatment delays. We aimed to characterize STEMI patients presenting without complaints of pain to the emergency departments (EDs) in Singapore.MethodsRetrospective data were requested from the Singapore Myocardial Infarction Registry (SMIR), a national level registry in Singapore. Painless STEMI was defined as the absence of pain (chest, back, shoulder, jaw, and epigastric pain) during ED presentation. The primary outcome was door-to-balloon (D2B) time, defined as the earliest time a patient arrived in the ED to balloon inflation. Secondary outcomes were 1-month and 1-year mortality and occurrence of adverse events.ResultsFrom January 2010 to December 2012, the SMIR collected 6412 cases; 10.9% of patients presented without any pain. These patients were older (median age =75 v. 58 years old), more likely to be females (39.9% v. 16.1%), Chinese (74.9% v. 62.7%), obese (median body mass index [BMI] =24.5 v. 22.1), and with history of hypertension (71.1% v. 54.6%), diabetes mellitus (48.6% v. 37.0%), and acute myocardial infarction (20.0% v. 12.3%). They had a longer median D2B (80.5 v. 63 minutes, p<0.001) and a higher occurrence of 30-day (38.4% v. 5.7%) and 1-year mortality rates (47.3% v. 8.5%).ConclusionA small proportion of STEMI patients presented without any pain to the ED. They tended to have a higher D2B and risks of mortality. Targeted effort is required to improve diagnostic and treatment efficiency in this group.
ASSESSMENT OF NUTRIENT MANAGEMENT TECHNOLOGIES FOR EGGPLANT PRODUCTION UNDER SUBTROPICAL CONDITIONS: A COMPREHENSIVE APPROACH
Authors: BATABYAL K. , MANDAL B. , SARKAR D. , MURMU S. 
Published: September 2016

SUMMARYWe developed a protocol for comprehensive evaluation of nutrient management (NM) technologies for production of eggplant taking its yield, produce quality, profitability, energy balance and environmental sustainability in terms of upkeeping soil quality as the goal variables. Fifteen NM technologies comprising of three sources of nutrients viz., organics [vermicompost (VC), farmyard manure (FYM) and mustard oil cake (MOC)], inorganic fertilizations [recommended N–P–K at the rate of 100–22–42 kg ha−1and 150% of recommended N–P–K (NPK^)] and their selected combinations were tested for growing the plants. Integrated NM technology was proved to be socio-economically sound and environment-friendly practice. It helped to upkeep soil quality by improving soil organic carbon stock, microbial biomass carbon, bulk density and available nutrients in soils. Combining all the parameters by employing non-parametric evaluation of regression factor scores through principal component analysis, the NM technology of VC3 Mg ha−1+NPK^ was found to be the best when considering the marketable fruits (12.27 Mg ha−1), economic return (benefit-cost ratio 3.3; marginal rate of return 8.7), energy conserving efficiency (net energy 113.8 GJ ha−1), soil and crop quality for human welfare. Only organics were less productive and profitable, and energetically less efficient than the integrated and inorganic NM systems and as such may not be sustainable for eggplant production in subtropical India.
Seroprevalence of Trichinella infections in domestic dogs from Slovakia
Authors: Miterpáková M. , Antolová D. , Hurníková Z. , Březinová N. , Čabanová V. , Reiterová K. 
Published: September 2016

AbstractTrichinellosis is constantly present in the sylvatic cycle in Slovakia, with several sporadic human outbreaks registered since the 1960s. The largest outbreak of trichinellosis occurred in 1998 and was related to the consumption of dog meat that had been added to smoked pork sausages. The aim of this study was to estimate the seroprevalence of Trichinella infection in domestic dogs in various regions of Slovakia. Out of 439 dogs tested, 56 (12.8%) were classified as a seropositive based on the enzyme-linked immunosorbent assay (ELISA), with confirmation by Western blotting. The highest seropositivity was recorded among dogs from the eastern part of Slovakia, in the Prešov (22.9%) and Košice (17.1%) regions, long considered to be highly endemic for Trichinella occurrence and where the prevalence of infection in the vulpine population is also the highest in Slovakia. Trichinella-seropositive animals were detected significantly more often in dogs kept in rural areas (21.1%) when compared with animals living in towns or suburban localities (7.7%). On the other hand, neither age, nor gender and size of the dogs were shown to be a significant factor for Trichinella infection (P > 0.05). The present results indicate that the dog population in Slovakia is at high risk of exposure to Trichinella parasites and could potentially represent a suitable host group for serological monitoring of Trichinella infection as convenient sentinel animals.
The impact of postpartum post-traumatic stress disorder symptoms on child development: a population-based, 2-year follow-up study
Authors: Garthus-Niegel S. , Ayers S. , Martini J. , von Soest T. , Eberhard-Gran M. 
Published: September 2016

BackgroundAgainst the background of very limited evidence, the present study aimed to prospectively examine the impact of maternal postpartum post-traumatic stress disorder (PTSD) symptoms on four important areas of child development, i.e. gross motor, fine motor, communication and social–emotional development.MethodThis study is part of the large, population-based Akershus Birth Cohort. Data from the hospital's birth record as well as questionnaire data from 8 weeks and 2 years postpartum were used (n= 1472). The domains of child development that were significantly correlated with PTSD symptoms were entered into regression analyses. Interaction analyses were run to test whether the influence of postpartum PTSD symptoms on child development was moderated by child sex or infant temperament.ResultsPostpartum PTSD symptoms had a prospective relationship with poor child social–emotional development 2 years later. This relationship remained significant even when adjusting for confounders such as maternal depression and anxiety or infant temperament. Both child sex and infant temperament moderated the association between maternal PTSD symptoms and child social–emotional development, i.e. with increasing maternal PTSD symptom load, boys and children with a difficult temperament were shown to have comparatively higher levels of social–emotional problems.ConclusionsExamining four different domains of child development, we found a prospective impact of postpartum PTSD symptoms on children's social–emotional development at 2 years of age. Our findings suggest that both boys and children with an early difficult temperament may be particularly susceptible to the adverse impact of postpartum PTSD symptoms. Additional studies are needed to further investigate the mechanisms at work.
Effects of early life stress on depression, cognitive performance and brain morphology
Authors: Saleh A. , Potter G. G. , McQuoid D. R. , Boyd B. , Turner R. , MacFall J. R. , Taylor W. D. 
Published: September 2016

BackgroundChildhood early life stress (ELS) increases risk of adulthood major depressive disorder (MDD) and is associated with altered brain structure and function. It is unclear whether specific ELSs affect depression risk, cognitive function and brain structure.MethodThis cross-sectional study included 64 antidepressant-free depressed and 65 never-depressed individuals. Both groups reported a range of ELSs on the Early Life Stress Questionnaire, completed neuropsychological testing and 3T magnetic resonance imaging (MRI). Neuropsychological testing assessed domains of episodic memory, working memory, processing speed and executive function. MRI measures included cortical thickness and regional gray matter volumes, with a priori focus on the cingulate cortex, orbitofrontal cortex (OFC), amygdala, caudate and hippocampus.ResultsOf 19 ELSs, only emotional abuse, sexual abuse and severe family conflict independently predicted adulthood MDD diagnosis. The effect of total ELS score differed between groups. Greater ELS exposure was associated with slower processing speed and smaller OFC volumes in depressed subjects, but faster speed and larger volumes in non-depressed subjects. In contrast, exposure to ELSs predictive of depression had similar effects in both diagnostic groups. Individuals reporting predictive ELSs exhibited poorer processing speed and working memory performance, smaller volumes of the lateral OFC and caudate, and decreased cortical thickness in multiple areas including the insula bilaterally. Predictive ELS exposure was also associated with smaller left hippocampal volume in depressed subjects.ConclusionsFindings suggest an association between childhood trauma exposure and adulthood cognitive function and brain structure. These relationships appear to differ between individuals who do and do not develop depression.
LAST RESORT OR KEY RESOURCE? WOMEN WORKERS FROM THE NAZI-OCCUPIED SOVIET TERRITORIES, THE REICH LABOUR ADMINISTRATION AND THE GERMAN WAR EFFORT
Authors: Harvey Elizabeth 
Published: September 2016

ABSTRACTForeign labour was an essential resource for the Nazi war economy: by September 1944, around six million civilian labourers from across Europe were working in the Reich. Any initial readiness on the part of the peoples of Nazi-occupied Europe to volunteer for work in the Reich had quickly dissipated as the harsh and often vicious treatment of foreign workers became known. The abuse and exploitation of foreign forced labourers by the Nazi regime is well documented. Less well understood is why women formed such a substantial proportion of the labour recruited or forcibly deported from occupied eastern Europe: in September 1944, a third of Polish forced labourers and just over over half of Soviet civilian forced labourers were women. This article explores the factors influencing the demand for and the supply of female labour from the Nazi-occupied territories of the Soviet Union, particularly after the appointment of Fritz Sauckel as Plenipotentiary for Labour in March 1942. It explores the attitudes of labour officials towards these women workers and shows how Nazi gender politics and the Nazi hierarchy of race intersected in the way they were treated.
Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury
Authors: Gong Wei , Guo Mengzheng , Han Zhibo , Wang Yan , Yang Ping , Xu Chang , Wang Qin , Du Liqing , Li Qian , Zhao Hui , Fan Feiyue , Liu Qiang 
Published: September 2016

AbstractThe loss of stem cells residing in the base of the intestinal crypt has a key role in radiation-induced intestinal injury. In particular, Lgr5+ intestinal stem cells (ISCs) are indispensable for intestinal regeneration following exposure to radiation. Mesenchymal stem cells (MSCs) have previously been shown to improve intestinal epithelial repair in a mouse model of radiation injury, and, therefore, it was hypothesized that this protective effect is related to Lgr5+ ISCs. In this study, it was found that, following exposure to radiation, transplantation of MSCs improved the survival of the mice, ameliorated intestinal injury and increased the number of regenerating crypts. Furthermore, there was a significant increase in Lgr5+ ISCs and their daughter cells, including Ki67+ transient amplifying cells, Vil1+ enterocytes and lysozyme+ Paneth cells, in response to treatment with MSCs. Crypts isolated from mice treated with MSCs formed a higher number of and larger enteroids than those from the PBS group. MSC transplantation also reduced the number of apoptotic cells within the small intestine at 6 h post-radiation. Interestingly, Wnt3a and active β-catenin protein levels were increased in the small intestines of MSC-treated mice. In addition, intravenous delivery of recombinant mouse Wnt3a after radiation reduced damage in the small intestine and was radioprotective, although not to the same degree as MSC treatment. Our results show that MSCs support the growth of endogenous Lgr5+ ISCs, thus promoting repair of the small intestine following exposure to radiation. The molecular mechanism of action mediating this was found to be related to increased activation of the Wnt/β-catenin signaling pathway.
Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis
Authors: Livne-Bar Izhar , Lam Susy , Chan Darren , Guo Xiaoxin , Askar Idil , Nahirnyj Adrian , Flanagan John G , Sivak Jeremy M 
Published: September 2016

AbstractReactive gliosis is an early pathological feature common to most neurodegenerative diseases, yet its regulation and impact remain poorly understood. Normally astrocytes maintain a critical homeostatic balance. After stress or injury they undergo rapid parainflammatory activation, characterized by hypertrophy, and increased polymerization of type III intermediate filaments (IFs), particularly glial fibrillary acidic protein and vimentin. However, the consequences of IF dynamics in the adult CNS remains unclear, and no pharmacologic tools have been available to target this mechanism in vivo. The mammalian retina is an accessible model to study the regulation of astrocyte stress responses, and their influence on retinal neuronal homeostasis. In particular, our work and others have implicated p38 mitogen-activated protein kinase (MAPK) signaling as a key regulator of glutamate recycling, antioxidant activity and cytokine secretion by astrocytes and related Müller glia, with potent influences on neighboring neurons. Here we report experiments with the small molecule inhibitor, withaferin A (WFA), to specifically block type III IF dynamics in vivo. WFA was administered in a model of metabolic retinal injury induced by kainic acid, and in combination with a recent model of debridement-induced astrocyte reactivity. We show that WFA specifically targets IFs and reduces astrocyte and Müller glial reactivity in vivo. Inhibition of glial IF polymerization blocked p38 MAPK-dependent secretion of TNF-α, resulting in markedly reduced neuronal apoptosis. To our knowledge this is the first study to demonstrate that pharmacologic inhibition of IF dynamics in reactive glia protects neurons in vivo.