bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conclusion: sustainability, smart tourism destinations and evolving visitor preferences
Authors: Akbaba Atilla 
Published: October 2024

PurposeThe primary aim of this themed issue is to highlight the incorporation of sustainability principles in the progress of tourism and the monitoring of tourists' evolving preferences, all within the sustainability framework and smart tourism destinations. The strategic question underlying this theme issue is how can we interpret, relate and monitor the rapidly evolving visitor preferences within sustainability and smart tourism destinations?Design/methodology/approachThis issue’s critical outcomes as they relate to the strategic question are reviewed, with reference to the contributions made to knowledge, policy and practice and the implications for future applied research concerning sustainability, smart tourism destinations and evolving visitor preferences.FindingsArising from the analysis and synthesis of recommendations, the following themes were proposed as critical concentration points for rapidly evolving visitor preferences within sustainability and smart tourism destinations: as in all areas of life, sustainability will continue to be a prominent concept in the tourism sector. Smart solutions and the use of technology have also been identified as determining factors in creating sustainable destinations. On the other hand, changing and evolving tourist preferences are emerging as a driving force for smart destinations and sustainability. Tourism destinations must take steps toward sustainability by considering the changing visitor structure, evolving demands and needs. Some articles in this special issue also analyze tourist demands and sustainability efforts of destinations in specific destinations and provide invaluable insights.Originality/valueAs it is essential for all stakeholders of the tourism industry to achieve competitiveness while securing sustainability, this particular article suggests ways for the industry as a whole, its players, destination administrations, local and national policymakers and other major stakeholders of the tourism industry to address some issues faced by the industry. Factors such as changing customer structure, use of technology and increasing environmental awareness make it necessary for destination management and all players individually to take vital measures. This paper and the collection of articles in this thematic issue offer crucial insights for academics, professionals and decision-makers in creating a complete framework to assess, connect and regularly track changing visitor preferences. The papers include recommendations for creating robust tourism locations that effectively tackle challenges, promote inclusion and prepare for future advancements. This is achieved by examining the convergence of sustainability, smart tourism and changing tourist tastes.
Asia‐Pacific consensus recommendations on the management of generalized pustular psoriasis
Authors: Choon Siew Eng , Foley Peter Anthony , Asawanonda Pravit , Fujita Hideki , Jo Seong‐Jin , Shi Yu‐ling , Theng Colin , Affandi Azura Mohd , Bang Chul Hwan , Frez Maria Lorna , Huei Huang Yu , Le Huu Doanh , Kim Tae‐Gyun , Morita Akimichi , Oon Hazel H. , Fernández‐Peñas Pablo , Rajatanavin Natta , Robinson Suganthy , Selvarajah Latha , Tsai Tsen‐Fang 
Published: October 2024

AbstractGeneralized pustular psoriasis (GPP) is a rare, chronic, heterogeneous, and potentially life‐threatening disease characterized by primary, sterile, and macroscopically visible pustules with or without systemic symptoms. There are ethnic differences in the genetic mutations associated with GPP that might affect the clinical manifestations and treatment responses. Currently, there is limited evidence from the patient population in the Asia‐Pacific (APAC) region, resulting in a general paucity of information on the effective management of patients with GPP in this region. This modified Delphi panel study aimed to identify current evidence and gain advanced insights to facilitate the development of a regionally tailored APAC consensus on the management of GPP. A systematic literature review (SLR) was conducted to identify published literature and develop consensus statements on (i) definition and clinical course, (ii) diagnosis of GPP, (iii) treatment outcomes, goals, and monitoring measures, and (iv) optimal management strategies and clinical practices. Statements were rated by a panel of dermatologists in two rounds, with the threshold for consensus at ≥80% agreement. Twenty experts from the APAC region reached consensus on 106 statements that were developed based on the SLR and experts' collective expertise. The experts agreed that GPP is a rare, severe, and potentially life‐threatening condition that is distinct from plaque psoriasis. This consensus emphasized the importance of a tailored treatment strategy taking into account the GPP flare severity and each patient's unique clinical circumstances. The experts reached consensus on the severity classification of GPP flares and recommended first‐line and maintenance treatment options for adult GPP, childhood GPP, and GPP in pregnancy. These consensus outcomes have been synthesized into treatment algorithms to guide dermatologists in the APAC region in their clinical decision‐making processes.
Chromosome‐level genome of diamondback terrapin provides insight into the genetic basis of salinity adaptation
Authors: JIANG Hui , WANG Zhongkai , ZHAI Xiaofei , MA Guangwei , WANG Tongliang , KONG Fei , LUO Wenkai , YU Ziwei , LI Haorong , REN Yandong , GUO Rui , JIAN Li , ZHAO Longhui , ZUO Ziye , PAN Shoupeng , QI Zan , ZHANG Yuxin , LIU Zhuoya , RAO Dingqi , LI Yongxin , WANG Jichao 
Published: October 2024

AbstractDiamondback terrapins (Malaclemys terrapin centrata) exhibit strong environmental adaptability and live in both freshwater and saltwater. However, the genetic basis of this adaptability has not been the focus of research. In this study, we successfully constructed a ∼2.21‐Gb chromosome‐level genome assembly for M. t. centrata using high‐coverage and high‐depth genomic sequencing data generated on multiple platforms. The M. t. centrata genome contains 25 chromosomes and the scaffold N50 of ∼143.75 Mb, demonstrating high continuity and accuracy. In total, 53.82% of the genome assembly was composed of repetitive sequences, and 22 435 protein‐coding genes were predicted. Our phylogenetic analysis indicated that M. t. centrata was closely related to the red‐eared slider turtle (Trachemys scripta elegans), with divergence approximately ∼23.6 million years ago (Mya) during the early Neogene period of the Cenozoic era. The population size of M. t. centrata decreased significantly over the past ∼14 Mya during the Cenozoic era. Comparative genomic analysis indicated that 36 gene families related to ion transport were expanded and several genes (AQP3, solute carrier subfamily, and potassium channel genes) underwent specific amino acid site mutations in the M. t. centrata genome. Changes to these ion transport‐related genes may have contributed to the remarkable salinity adaptability of diamondback terrapin. The results of this study not only provide a high‐quality reference genome for M. t. centrata but also elucidate the possible genetic basis for salinity adaptation in this species.
Effect of orange‐fleshed sweet potato (Ipomoea batatas)–Bambara groundnut (Vigna subterranea) composite flour on quality properties of pasta
Authors: Makhuvha Makgwatla Consolerlia , Laurie Sunette , Mosala Mmathaha 
Published: October 2024

AbstractNon‐wheat flours are gaining attention as substitutes for wheat flour, offering the potential to optimize local resource utilization and alleviate the demand for wheat. The study investigates the use of non‐wheat flours, particularly a blend of orange‐fleshed sweet potato (OFSP) (Ipomoea batatas) and Bambara groundnut (BG) (Vigna subterranean), as a partial replacement for wheat flour in pasta production. The aim is to improve the utilization of local resources, reduce the reliance on wheat, and enhance the nutritional quality of pasta. The production of OFSP and BG flour took place at Agricultural Research Council Roodeplaat Campus. The data were analyzed using analysis of variance, and significant means were separated using the Duncan multiple range test. The research found that pasta made from composite flour significantly influenced its composition and cooking characteristics when compared to 100% wheat pasta. The most nutritionally enriched pasta was achieved with a blend of 50% wheat, 25% OFSP, and 25% BG, featuring higher protein, ash, and fiber content. Consumers preferred pasta made from a composite flour of 70% wheat, 15% OFSP, and 15% BG. This research suggests the potential for producing pasta using OFSP and BG composite flour as a viable option.Practical ApplicationThe practical application of the research on orange‐fleshed sweet potatoes–Bambara groundnut‐based pasta has the potential to improve nutrition, stimulate local economies, enhance agricultural sustainability, and promote food security in regions where vitamin A deficiency is a concern and wheat importation is high.
Association between coffee consumption and metabolic syndrome: A cross‐sectional and Mendelian randomization study
Authors: Wong Tommy Hon Ting , Luo Shan , Au Yeung Shiu Lun , Louie Jimmy Chun Yu 
Published: October 2024

AbstractBackgroundThis study investigates the associations between coffee consumption and metabolic syndrome and its components, as well as the effect of milk, sugar, and artificial sweeteners on these associations.MethodsA cross‐sectional analysis was conducted with 351805 UK Biobank participants. Coffee consumption data were collected via food frequency questionnaires and 24‐h recall. Metabolic syndrome was identified through blood biochemistry and self‐reported medication use. Odds ratios were calculated using multivariable logistic regression, and results were verified with two‐sample Mendelian randomization.ResultsConsuming up to two cups of coffee per day was inversely associated with metabolic syndrome (1 cup/day: odds ratio [OR]: 0.88, 95% confidence interval [CI]: 0.85–0.92; 2 cups/day: OR: 0.90, 95% CI: 0.86–0.93). Higher intakes showed near‐null associations. Mendelian randomization did not support a causal link between coffee intake and metabolic syndrome. Both self‐reported and genetically predicted high coffee consumption (four cups per day or more) were associated with central obesity. The inverse association between coffee consumption and metabolic syndrome was more profound among drinkers of ground coffee than those of instant coffee. Results were similar when stratified by the use of milk and sugar, yet the use of artificial sweetener with coffee was positively associated with metabolic syndrome and all component conditions.ConclusionsCoffee consumption may increase the risk of central obesity but is unlikely to impact the risk of metabolic syndrome. The potential health effects of artificial sweeteners in coffee need further investigation.image
Indocyanine green localization for preoperative CT‐guided localization of multiple pulmonary nodules
Authors: Zhang Shenbo , Cao Jian , Wang Kefei , Wang Zhiwei , Jin Zhengyu 
Published: October 2024

AbstractObjectivesThis study assesses the safety and efficacy of using indocyanine green (ICG) for preoperative CT‐guided localization of multiple pulmonary nodules.MethodsWe included patients who underwent CT‐guided preoperative ICG localization followed by video‐assisted thoracoscopic surgery (VATS). Four primary outcomes were evaluated: technical success, pneumothorax, pulmonary hemorrhage, and postoperative hospital stay (PHS). Patients were classified into single nodule and multiple nodules groups, with further subgroups based on the side of localization including unilateral and bilateral subgroups. Univariate and multivariate analyses were used to evaluate risk factors for PHS and pneumothorax.ResultsA total of 374 patients (54.8 ± 11.4 years, 99 with multiple nodules). The success rate in the multiple nodules group was 98.3%, similar to single nodules. Apart from PHS, no significant differences were observed in outcomes between patients with single and multiple nodules. Longer PHS was observed for patients with multiple nodules (3 [2–4] days vs. 3 [3–4] days, p = 0.022). Multivariable analysis indicated longer stays were associated with pulmonary hemorrhage during localization, surgical blood loss, postoperative complications, and non‐segmentectomy procedures. Advanced age emerged as the sole independent risk factor for pneumothorax. The success rate in the unilateral subgroup and the bilateral subgroup was 97.8% and 99%, respectively, with higher pneumothorax rates in the unilateral subgroup (38.3% vs. 20%).ConclusionCT‐guided preoperative ICG localization of multiple pulmonary nodules is safe and effective. It can be applied to both unilateral and bilateral nodules, supporting simultaneous VATS resection.
Postoperative analgesic effectiveness of ultrasound‐guided bilateral erector spinae plane block vs. rectus sheath block for midline abdominal surgery in a low‐ and middle‐income country: a randomised controlled trial
Authors: Urmale Kusse Alemu , Legesse Mebratu , Assefa Andualem , Tila Mebratu , Sintayhu Ashagrie , Mequanint Addisu , Markos Mekdes , Kussia Wendafrash , Dendir Getahun , Gebremedhin Tsegaye Demeke , Sidamo Temesgen , Obsa Mohammed Suleiman 
Published: October 2024

SummaryIntroductionThe use of erector spinae plane block and rectus sheath block for postoperative analgesia in midline abdominal procedures is becoming more common. However, the most effective and appropriate method remains unclear. We aimed to compare the postoperative analgesic effecacy of ultrasound‐guided bilateral erector spinae plane blocks with rectus sheath blocks for midline abdominal surgery in a low‐ and middle‐income country.MethodsWe allocated randomly 72 patients aged 18–65 y undergoing midline abdominal surgery to an erector spinae plane block (n = 36) or a rectus sheath block (n = 36) utilising a prospective, parallel study design. Patients, care providers and outcome assessors were blinded to the interventions. The primary outcome measures were total postoperative analgesia consumption, postoperative pain severity and time to first rescue analgesic administration. Secondary outcomes included the incidence of postoperative complications and adverse events.ResultsOf 78 patients assessed for eligibility, six were excluded, leaving 72 for analysis. Patients allocated to erector spinae plane block had a lower mean (SD) postoperative opioid consumption compared with those allocated to rectus sheath block (3.5 (8.7) morphine milligram equivalents vs. 8.2 (2.8) morphine milligram equivalents, respectively; p = 0.003). Time to first analgesic request was greater in patients allocated to erector spinae plane block compared with those allocated to rectus sheath block (mean (95%CI) 16 (13–17) h vs. 12 (11–13) h, respectively; p < 0.001). There were no block‐related complications in either group.DiscussionErector spinae plane blocks are more effective than rectus sheath blocks for the management of postoperative pain following midline abdominal surgery. Integration of erector spinae plane blocks into multimodal opioid‐sparing analgesic strategies after midline abdominal surgeries may promote enhanced patient recovery in low‐and middle‐income countries.
Cross‐Cultural Differences in the Pathways to Internet Gaming Disorder
Authors: Chew Peter K. H. , Lin Patrick K. F. , Yow Yong Jie 
Published: October 2024

ABSTRACTBackgroundNo research to date has examined cross‐cultural differences in the pathways to internet gaming disorder (IGD). The current study aimed to address this limitation by examining the relationships between nationality (Singaporeans vs. Australians), culture orientation, gaming motivations, and IGD.MethodsParticipants were 101 Singaporeans (55.4% males) and 98 Australians (52.0% males). They completed the Culture Orientation Scale, the Motives for Online Gaming Questionnaire, and the Internet Gaming Disorder Scale‐Short‐Form.ResultsA series of mediational analyses showed that Singaporeans tend to be more collectivistic (both horizontally and vertically). In turn, this culture orientation motivates them to play games for social reasons, increasing the risk for IGD. In contrast, Australians tend to be more individualistic (vertically only). In turn, this culture orientation motivates them to play games for competitive reasons, increasing the risk for IGD.ConclusionLimitations include the use of samples from two countries only, precluding a generalization of the results. Future research directions include examining the role of game genres as a mediator in the nationality‐IGD relationship.
Training young co‐researchers to interview their parents: The transformative potential of intergenerational interviews
Authors: Walker Catherine , van Holstein Ellen 
Published: October 2024

AbstractThe turn to co‐production in geographical research is underpinned by the social justice aim to democratise academic practice, and in recent years this has extended to training young people as co‐researchers. However, discussions of intergenerational dynamics in co‐produced research are limited, and there are no accounts of family members interviewing one another. This paper responds to this oversight by presenting a reflective account of a research project centring on intergenerational family discussions and negotiations of climate change knowledge, in which young co‐researchers interviewed parents. We share key considerations for developing bespoke interview training and preparing co‐researchers to undertake interviewing, and we highlight the strengths and opportunities of intergenerational interviews in families. Our core contention is that, when planned and supported with tact and consideration, intergenerational interviews can boost young people's confidence in their skills and generate rich dialogues that may lead to decisions and outcomes that will outlive the research. However, engaging co‐researchers and their pre‐existing familial relationships in research requires careful consideration, practical training, and ongoing reflection, because these relationships are defined by intergenerational dynamics that precede and outlast the research.
Healthcare for People With Intellectual Disabilities: An Exploration of Intellectual Disability Service Providers' Experiences of Joint Working With Acute Service Providers When People With Intellectual Disabilities Access Healthcare in Acute Services
Authors: Kelleher Eileen , Caples Maria , Wills Teresa , Martin Anne‐Marie 
Published: October 2024

ABSTRACTBackgroundIndividuals with intellectual disabilities often require various supports in their everyday lives. Many access both acute and intellectual disability services depending on their needs. Previous research has highlighted suboptimal experiences of care provided in acute services. Joint working between both services has been recognised as a measure of improving healthcare for this group. Although there is some evidence regarding this issue from the perspective of acute service providers, further research is required to understand the perspective of intellectual disability service providers.MethodsTen nurses working in various roles in intellectual disability services across Ireland took part in semistructured interviews. The data were analysed using thematic analysis.FindingsIssues with inter‐service communication and insufficient policies, protocols and pathways were found to negatively impact joint working. Acute services seemed to have a limited understanding of the role and capacity of intellectual disability services. Acute services do not always identify the individual needs of the people in their care. Despite this, there were examples of joint working taking place that benefited those with intellectual disabilities.ConclusionsJoint working needs to include improving communication between both services, co‐developing policies, protocols and pathways and appointing acute care liaison nurses.
Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction
Authors: Machicoane Mickaël , Tonellato Marika , Zainotto Marica , Onillon Paul , Stazi Marco , Corso Mattia Dal , Megighian Aram , Rossetto Ornella , Le Doussal Jean‐Marc , Pirazzini Marco 
Published: October 2024

AbstractBackground and PurposeBotulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine. Notwithstanding great effectiveness, strategies to accelerate the onset and prolong BoNT/A action would significantly ameliorate its pharmacological effects with beneficial outcomes for clinical use.Experimental ApproachHere, we combined BoNT/A with two fast‐acting inhibitors of excitation–contraction coupling inhibitors (ECCI), either the μ‐conotoxin CnIIIC or dantrolene, and tested the effect of their co‐injection on a model of hind‐limb paralysis in rodents using behavioural, biochemical, imaging and electrophysiological assays.Key ResultsThe BoNT/A‐ECCI combinations accelerated the onset of muscle relaxation. Surprisingly, they also potentiated the peak effect and extended the duration of the three BoNT/A commercial preparations OnabotulinumtoxinA, AbobotulinumtoxinA and IncobotulinumtoxinA. ECCI co‐injection increased the number of BoNT/A molecules entering motoneuron terminals, which induced a faster and greater cleavage of SNAP‐25 during the onset and peak phases, and prolonged the attenuation of nerve‐muscle neurotransmission during the recovery phase. We estimate that ECCI co‐injection yields a threefold potentiation in BoNT/A pharmacological activity.Conclusions and ImplicationsOverall, our results show that the pharmacological activity of BoNT/A can be combined and synergized with other bioactive molecules and uncover a novel strategy to enhance the neuromuscular effects of BoNT/A without altering the neurotoxin moiety or intrinsic activity, thus maintaining its exceptional safety profile.