bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel Electric Fields and Electron Heating Observed in the Young Solar Wind
Authors: Mozer F. S. , Agapitov O. V. , Choi K.-E. , Sydora R. D. 
Published: February 2025

Abstract
The largest electric fields between 18 and 30 solar radii are in narrowband waves simultaneously observed at a few Hz (somewhat above the local proton gyrofrequency) and a few hundred Hz (far below the lower hybrid frequency), with the higher-frequency wave triggered at specific phases of the lower-frequency wave. This wave pair, called “triggered ion-acoustic waves” (TIAWs), has been shown to both be physical and to occur at times of electron heating. A theory of electron heating and acceleration by the low-frequency wave has been presented. While this theory and the TIAW results strongly suggest the presence of low-frequency electric fields that are parallel to the local magnetic field, such fields have not been directly observed. In this paper, such parallel electric field observations are reported, and TIAWs are further described to conclude that they occur during about 75% of the Parker Solar Probe passes through 18–30 solar radii, and when present, they are the dominant wave signal, lasting for hours. In the presence of these parallel electric fields, electrons are heated while, in their absence, there is no electron heating. That there is no heating between 18 and 30 solar radii in the absence of TIAWs is a most significant result because it invalidates other proposed mechanisms that predict heating in this radial range all of the time.
Des mathématiques à la docte ignorance selon Nicolas de Cues
Authors: Pasqua Hervé 
Published: February 2025

La vérité mathématique se propose à Nicolas de Cues comme précision absolue : un égale un. Sur ce modèle, il définit l’objet de la métaphysique comme l’Un en tant qu’Égalité absolue. En tant que tel, l’Un n’est rien d’étant. Au-delà de l’être, il n’est pas adéquation à l’être, mais égalisation de soi à soi dans le non-être. L’Égalité est sans contenu, elle est un acte pur par lequel l’Un se féconde comme Un. La connaissance n’est donc plus conçue comme adéquation de la pensée à son objet, elle tourne le dos à la définition de la vérité comme adequatio rei et intellectus. La correspondance avec la réalité disparaît. L’approche indéfinie de son objet constitue désormais la connaissance elle-même : approche conjecturale, ou symbolique, d’un objet toujours insaisissable, toujours lointain, reculant toujours à mesure qu’on l’approche. Telle est la méthode – le chemin – de la docte ignorance, qui inaugure la modernité selon Hans Blumenberg.
T-CELL RECEPTOR (TCR)-VΒ REPERTOIRE FLOW CYTOMETRY FOR T-CELL LYMPHOPROLIFERATIVE DISORDER: A RETROSPECTIVE ANALYSIS OF A SINGLE-CENTER REAL-LIFE LABORATORY EXPERIENCE
Authors: Antonacci Marco , Micozzi Jacopo , Costa Alessandro , Laganà Alessandro , Milani Maria Laura , Intoppa Stefania , Bellomarino Vittorio , Nardacci Maria Grazia , Biglietto Mario , Imperatore Stefano , Bisegna Maria Laura , Martelli Maurizio , Della Starza Irene , De Propris Maria Stefania 
Published: February 2025

Background: Discrimination between clonal and reactive cell proliferation is critical for the correct management of T-cell lymphocytosis. Multiparametric flow cytometry (MFC) represents a valuable tool, particularly because it allows to evaluate the T-cell receptor (TCR) Vβ repertoire to pinpoint eventual clonality in T-cell lymphocytosis. A restricted expansion of a single out of the 24 evaluable families or a “clonogram-off” pattern are highly suggestive of the presence of a clonal T-cell population. However, data available on the concordance between MFC TCR-Vβ repertoire and molecular analysis of TCR gene rearrangements, which is regarded as the gold standard for assessing T-cell clonality, are limited.
Objective and methods: We performed a retrospective monocentric study including 307 patients referred to our center for lymphocytosis between 2003 and 2024. The aim of our study was to investigate the diagnostic accuracy of MFC TCR-Vβ repertoire analysis and to compare its performance with molecular analysis of TCR gene rearrangements, for the identification of T-cell clonality.
Results: MFC TCR-Vβ repertoire analysis demonstrated a restricted expansion of a single Vβ family in 67.5% of cases, while clonality in the remaining 32.5% was inferred by a “clonogram-off” pattern. For 215 (70%) patients both MFC TCR-Vβ repertoire analysis and molecular analysis of TCR gene rearrangements were available, showing an absolute concordance (215 out of 215 cases, 100%) between the two methods.
Conclusion: MFC TCR-Vβ repertoire analysis is a rapid, cheap, sensitive, and reliable tool to identify clonal T-cell lymphocytosis. It represents an absolute valid first-line diagnostic approach, and it should be included into the routinely laboratory work-up performed MFC analysis for peripheral lymphocytosis.
Successful Management of Steroid-Resistant cutaneous Acute Graft-versus-Host Disease, Toxic Epidermal Necrolysis-Like, with Ruxolitinib
Authors: Ozturk Fahir , Pepeler Mehmet Sezgin , Ucaryilmaz Ozhamam Esra , Korkmaz Gulten 
Published: February 2025

A case of Acute graft-versus-host disease (aGVHD) with severe cutaneous manifestations resembling Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is presented.
Enablers for good governance based on open government initiatives for a South African municipality
Authors: Phahlane Mampilo , Malungana Lario 
Published: February 2025

Background: Open government policies, strategic documents and the use of information and communication technology tools are enablers of good governance, which is reflected in citizens’ satisfaction. Despite numerous open government initiatives introduced by various governments worldwide, there is insufficient literature detailing how open government influences governance in a typical municipality.Objectives: The main objective of this research is to investigate the adoption of open government initiatives in a typical South African municipality.Method: This study utilised institutional theory as a lens, as it accurately describes the setting of government, specifically at the municipal level. The researchers chose a purposeful sample of employees from the Buffalo City Metropolitan Municipality and employed an interpretive inductive qualitative case study method to uncover how open government policies and strategic documents facilitate good governance.Results: Data were collected through interviews, and thematic and content analysis were applied to analyse the collected data, uncovering depth and richness. The identified themes emerged from the website, call centres, social media and letters used to communicate with citizens.Conclusion: The study concludes that it is necessary to develop applications to assist government administration and enable citizens to interact in real time through live chats, discussions and online document reviews.Contribution: This study contributes to our understanding of institutional theory, which is inherently complex because of the governmental environment. It particularly focusses on the linkages, networks and couplings between public problems and public jurisdictions, highlighting their high interdependence.
The moderating effect of environmental dynamism on entrepreneurship and open innovation
Authors: Li Shichao , Zhang Kecheng 
Published: February 2025

Background: The effect of entrepreneurship on open innovation under challenging environmental dynamics remains an unresolved issue critical for global economic progress, as the environmental dynamics alter businesses’ capacity for entrepreneurship.Aim: This study aims to examine how entrepreneurship influences open innovation in Chinese companies by investigating the moderating role of environmental dynamism.Setting: A survey questionnaire collected data from 329 middle and senior managers in Shandong, Shanghai, Beijing and other provinces.Method: This study used hierarchical regression analysis as the data analysis method to test the causal relationships and mediating and moderating effects of each hypothesis.Results: It was found that entrepreneurship has a significant positive impact on open innovation in firms. Specifically, entrepreneurial risk-taking and anticipation positively affected open innovation behaviour and strategic orientation of innovation. Moreover, environmental dynamism moderated the relationship between entrepreneurial mechanisms and open innovation.Conclusion: The findings provided new insights into how environmental dynamism shapes the emergence of innovative companies in China. The study suggests entrepreneurs should adjust efforts to promote open innovation behaviour according to the degree of dynamism.Contribution: The study expands and improves the development of the resource-based view and the capability-based view from a theoretical perspective. Furthermore, it broadens the theoretical lens by examining how the strategic orientation of innovation towards entrepreneurship supports open innovation practices to improve the operational performance of organisations. Finally, this research empirically examined the moderating impact of environmental dynamism on the relationship between entrepreneurial strategic orientation and open innovation-based environmental dynamism on company performance.
Transitioning from Industry 4.0 to 5.0: Sustainable supply chain management and talent management insights
Authors: Samuels Alexander B. , Pelser Anna-Marie 
Published: February 2025

Orientation: A systematic literature review emphasises the importance of building a resilient and forward-looking industrial sector that can adapt to the evolving demands of Industry 5.0 as it transitions from Industry 4.0. The strategic recommendations from this review underscore the significance of sustainable supply chain management (SSCM) and effective talent management.Research purpose: This study aims to investigate how the transition from Industry 4.0 to Industry 5.0 impacts SSCM and talent management, based on a systematic review and synthesis of existing literature.Motivation for the study: The significance of the study lies in understanding the profound implications of Industry 5.0 on supply chain sustainability and workforce development, particularly in the context of integrating human-centric and sustainable practices with advanced digital technologies.Research approach/design and method: The study employs the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to conduct a comprehensive systematic review. It synthesises existing literature focussing on the technological advancements, human resource challenges and sustainable practices adopted by industries transitioning from Industry 4.0 to Industry 5.0.Main findings: The study reveals that industries are increasingly integrating advanced technologies such as artificial intelligence (AI), big data analytics and blockchain to improve supply chain efficiency and sustainability. Significant emphasis is placed on reskilling and upskilling the workforce to align with the demands of new technologies and human-centric industrial processes.Practical/managerial implications: The findings highlight the key role of policymakers, industry leaders, and educational institutions in driving the successful adaptation to Industry 5.0. Policymakers must prioritise funding and supportive regulations, while industry leaders need to embrace ongoing upskilling initiatives.Contribution/value-add: The study proposes several strategic recommendations, including the development of inclusive digital infrastructure, encouraging industry collaborations to align educational curricula with market needs and promoting continuous professional development for employees. These recommendations aim to facilitate a resilient and forward-thinking industrial sector capable of meeting the evolving demands of Industry 5.0.
Geloofsontwikkeling: ’n Geloofsreis met roetemerkers
Authors: Greyling Anandie , Nel Malan 
Published: February 2025

Faith development: A journey through faith with route markers. The article explores the stage of adolescence and its characteristics, specifically concerning faith formation. It discusses the theological rationale for reaffirming one’s faith at various life transitions and rites of passage, focusing on how it can be implemented during adolescence.Intradisciplinary and/or interdisciplinary implications: This article draws on research regarding ‘roetemerkers’ and the efforts of a task team from the Dutch Reformed church. Furthermore, it forms part of a series of articles based on research within certain Afrikaans Reformed Churches, focusing on children and adolescents’ faith formation.
Toerusting van begeleiers op die geloofsreis
Authors: Hoffman Lyzette 
Published: February 2025

Equipping companions on the journey of faith. Faith formation is a multifaceted process involving various role players. Parents, pastors, mentors, catechists, youth leaders, and church board members all play a significant role in a congregation’s faith formation. This article examines the need to equip individuals engaged in this process. The specific roles they undertake will determine the type of training required. Using didache as a foundation, the focus will be on mentoring and serving as role models. Encouraging adults to participate in training presents its own challenges, which can be addressed through a variety of approaches. The research identified key training needs, including the faith development of catechists, an understanding of the lifeworld of children and adolescents (their developmental stages), and the skills required to convey content effectively. Another crucial area of training is koinonia – the building of relationships.Intradisciplinary and/or interdisciplinary implications: Transformative leadership is essential to inspire those involved in faith formation to commit to becoming equipped to achieve excellence in their roles.
Disseminated BCGosis in an infant with mendelian susceptibility to mycobacterial diseases: A case report
Authors: Mena Ganesh Shashank , Rangaswamy Darshan Rajatadri , Kamble Niranjan , Kumar Vikram S 
Published: February 2025

Rationale:
Primary immunodeficiency disorders can be fatal especially in infants. Prompt recognition with a comprehensive medical history, genetic evaluation, and appropriate treatment can be lifesaving in a few subtypes.

Patient concerns:
A 4-month-old male infant presented with axillary swelling, fever, and ulcerative lesions. Despite care at multiple facilities, symptoms persisted, raising concern for an underlying immunodeficiency. The patient's sibling had similar symptoms and died at six months, suggesting a genetic predisposition.

Diagnosis:
Mendelian susceptibility to mycobacterial disease, IFNGR2 deficiency.

Interventions:
The patient was treated with tailored anti-tubercular therapy and azithromycin prophylaxis.

Outcomes:
Following treatment, the patient’s symptoms have resolved. At 20 months, he is thriving with normal development.

Lessons:
This case highlights the importance of a thorough medical history and genetic testing in infants with recurrent or unusual infections. Early diagnosis of mendelian susceptibility to mycobacterial disease can lead to effective treatment and better outcomes.
COVID-19 vaccination in patients on biologic or targeted-synthetic disease modifying anti-rheumatic drug therapy: A multi center real-world data
Authors: Yildirim Tuba Demirci , Akleylek Cansu , Yıldırım Derya , Cinakli Haluk , Hakbilen Selda , Coşkun Belkıs Nihan , Okyar Burak , Işık Özlem Özdemir , Sağır Rabia Pişkin , Apaydın Hakan , Karakaş Ali , Erez Yeşim , İnel Tuba Yüce , Gülle Semih , Tufan Abdurrahman , Akar Servet , Yılmaz Sema , Yılmaz Neslihan , Pehlivan Yavuz , Çetin Gözde Yıldırım , Çefle Ayşe , Koca Süleyman Serdar , Erten Şükran , Dalkılıç Ediz , Yazıcı Ayten , Şen Gerçek , Sarı İsmail , Birlik Ahmet Merih , Onen Fatoş 
Published: February 2025

Objective:
To assess the effectiveness of COVID-19 vaccination in patients with rheumatic diseases undergoing biologic (bDMARDs) or targeted-synthetic disease-modifying anti-rheumatic drugs (tsDMARDs).

Methods:
This cross-sectional study was conducted at ten rheumatology clinics in Turkey between May 1, 2021, and October 30, 2022. Patients with rheumatic diseases on bDMARD or tsDMARD therapy who received at least two doses of an mRNA or inactivated SARS-CoV-2 vaccine were included. After vaccination, COVID-19 infection rates, adverse events, and rheumatic disease flares were recorded. Data were collected via face-to-face or telephone interviews.

Results:
A total of 963 participants were included in the final analysis; 44% were male, and the median age was 49 years. The most frequently observed rheumatic diseases were ankylosing spondylitis and rheumatoid arthritis, accounting for 37.2% and 32.6% of cases, respectively. Adalimumab (19.2%) and infliximab (17.8%) were the most commonly used bDMARDs. Of the participants, 634 (65.9%) received an inactivated vaccine (CoronaVac) and 329 (34.1%) an mRNA vaccine (BioNTech). A total of 502 (52.1%) patients received a booster dose. Following the first, second, and third vaccine doses, adverse event rates were 19.9%, 15.9%, and 26.7%, respectively. Forty-two (4.4%) patients experienced a disease flare within six months after their first vaccination dose. COVID-19 infection occurred in 79 participants (8.2%) after two vaccine doses; most cases were symptomatic but did not require hospitalization. The COVID-19 infection rate was lower in participants who received a booster dose than those who did not (3.4% vs. 8.2%, P<0.001).

Conclusions:
Our study indicates that both mRNA and inactivated SARS-CoV-2 vaccines are effective in preventing severe COVID-19 outcomes, with an acceptable rate of adverse events and disease flares among patients with rheumatic diseases on bDMARD or tsDMARD therapy.
Clinical Study for Validation of Safety and Efficacy of Sharbat Zufa Murakkab in Su‘āl-i-Ratb (Productive Cough) in Eastern India
Authors: Rasheed Abdur , Khan Hakimuddin , Kumar Kishore , Singh Narendra , Zakir Mohammad , Jamali Akhtar Hussain , Siddiqui Ziaul Haq , Saifi Mustehsan 
Published: February 2025

Abstract

Background:
Cough is the most common symptom of respiratory tract disease. It is caused by the mechanical or chemical stimulation of the cough receptors in the epithelium of the pharynx, larynx, trachea, and bronchi. It is an explosive expiration that provides a normal protective mechanism for clearing the tracheobronchial tree of secretions and foreign material. Cough can be initiated by a variety of irritant triggers either from an exogenous source (smoke, dust, fumes foreign bodies, etc.) or from an endogenous origin (upper airway secretions and/or gastric contents).

Aims and Objectives:
The present clinical study was performed to validate the safety and efficacy of Unani Pharmacopoeial formulation “Sharbat Zufa Murakkab” on scientific parameters, in patients of Su‘āl-i-Ratb (productive cough).

Material and Method:
This study was carried out at the Regional Research Institute of Unani Medicine, Bhadrak (Odisha) during the year 2013–2015. A total of 67 patients completed the study out of all registered cases. The treatment duration was of 15 days and the patients of either sex in the age group of 18–65 years were selected for the study with the complaints of cough for more than 3 days associated with expectoration, Khushūna al-Halaq (sore throat), Buhha al-Sawt (hoarseness of voice), and chest tightness.

Result:
Nearly 91% of cases have shown more than 60% relief in signs and symptoms of the disease as compared to baseline. The variations in the values of liver function tests and kidney function tests before and after treatment were found within normal limits.

Conclusion:
The test drug has shown very good results. It was found well tolerated and no adverse effects were observed during the study. The study is asserting the safety and efficacy of “Sharbat Zufa Murakkab” in the treatment of Su‘āl-i-Ratb (productive cough).
Therapeutic Values of Frequently Used Unani Drug Turbud (Operculina turpethum (L.) Silva Manso: A Comprehensive Review
Authors: Ahmad Ishtiyaq , Siddiqui Javed Inam , Alam Abrar , Kazmi Munawwar Husain , Zahid Uzma 
Published: February 2025

Abstract
Plants are always considered for their multidimensional approach from livelihood to medicinal use. Traditional Systems of Medicine including the Unani System of Medicine (USM) have a treasure of important Medicinal plants. Turbud is one of the important Medicinal plants of the USM. The root powder of the drug is used for the treatment of rheumatism, flatulence, paralysis, scorpion sting, snakebite, and skin disorders (such as Vitiligo, eczema, abscesses, acne, scabies, and warts). It is used frequently for Mushil (i.e., therapeutic purgation) in USM. The rhizomes/roots are phlegm-purgative and used for the treatment of phlegmatic and nervous diseases, such as Wajʻal Mafāsil (Arthritis), Irqun Nisa (Sciatica) Niqras (Gout), Fālij (Paralysis) Laqwa (facial palsy), Ḍῑq al-Nafas (bronchial asthma), and Suʻal (cough). The present review comprehensively integrates the pharmacognosy, therapeutic uses, and pharmacology and some evidence-based scientific studies of O. Turpethum related to its efficacy like anti-inflammatory, anticancer, cytotoxic, antisecretory, ulcer protective, hepatoprotective, and antibacterial activities also incorporated.
A systematic review of occupation- and activity-based health management interventions for adult patients with severe mental disorders
Authors: Nasiri Elham , Karbalaei Nouri Ashraf , Hosseini Seyed Ali , Mandani Ghazaleh 
Published: February 2025

BACKGROUND:
Considering the negative effects of severe mental disorders (SMDs) on the patient’s social and occupational functioning and general health, besides accumulating evidence on the effectiveness of occupation- and activity-based health management interventions for these patients and the novelty of research on this topic, it is important to review, evaluate, and categorize relevant studies. The present study aimed to systematically review occupation- and activity-based health management interventions for adult patients with SMDs.

MATERIALS AND METHODS:
The present study is a systematic review. We conducted a literature search in Medline, OTseeker, Cochrane Library, Embase, CINAHL, PubMed, PsycINFO, ISI Web of Science, MagIran, ISC, and SID databases from 2000 until October 2021. The study population consisted of patients clinically diagnosed with SMDs (e.g., schizophrenia, bipolar disorder, and major depression). After the literature search, we investigated the screening, quality, and inclusion and exclusion criteria of the articles. In the primary search, we extracted 238 relevant articles, and after appraising their titles and abstracts, we identified 55 relevant articles. After reviewing the full text of the articles and removing duplicates, 17 articles met the inclusion criteria of this study, while we excluded two articles from the quality assessment. Finally, we reviewed 15 studies. The outcomes included all positive and negative treatment effects and outcomes of the interventions.

RESULTS:
According to the results, there were multiple occupation- and activity-based interventions for patients with SMDs, which could directly or indirectly improve their general functioning and health management.

CONCLUSION:
The reviewed studies had numerous blind spots and limitations, such as common shortcomings of randomized clinical trials, lack of long follow-ups, and ambiguity or dispersion of intervention protocols. Besides addressing these limitations, we also discussed research proposals in this study.