bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-silico identification of cis- acting regulatory elements in 5’ regulatory region of Betaine aldehyde dehydrogenase isoenzymes of selected monocot and dicot
Authors: Sharma Hemani , Govil Sumit , Shrivastava Divya 
Published: January 2018

It’s challenging to understand the multifarious gene regulatory networks. Diverse biological processes, are mostly conferred by nature of cis-acting regulatory elements (CARE) located within the regulatory region which include abiotic stress responses, hormone responses and developmental processes. Thus, the identification of CARE and their organization is a crucial step for better understanding of spatiotemporal expression of the gene. The putative cis-acting element that are located within the 5' regulatory region of BADH isozymes of Hordeum vulgare , Oryza sativa, Sorghum bicolor, Leymus chinensis, Zoysia tenuifolia, Arabidopsis thaliana, Amaranthus hypochondriacus, Chrysanthemum lavandulifolium, Populus euphratica and Atriplex prostrate were identified using bioinformatics tools. Several probable cis-acting regulatory elements that are coupled with cellular development, hormonal and stress response were identified as: Me-JA, GARE, GT-1, MYB, W-box, I-box, Pyrimidine-box, ANAERO, ARF, CARE, ASF1, SORLIP, SURE, TAAAGSTKST1, GCC Box, CICADIAN, Sp1 and CGCG Box. These results shed light on probable cis-acting regulatory elements these BADH isoenzyme that confer their expression and regulation during cellular, hormonal and stress response.
RELATION OF HEART WEIGHT WITH AGE AND WEIGHT OF CADAVER
Authors: Agarwal Jolly , Kumar Virendra 
Published: January 2018

Introduction: Height, weight, and age of person has significant impact on the normal size of
heart. These parameters need to be considered when cut-off values indicating the need for
treatment or even surgery are established. The aim of present work is to study the relation of
weight of the heart with age and weight of cadaver.
Material and Methods: The study was performed in the Department of Anatomy, Shri Ram
Murti Smarak Institute of Medical Sciences, Bareilly on 30 hearts from embalmed cadavers.
The hearts were procured from the cadavers available in our department. The heart was
thoroughly cleaned and measurements were taken.
Results: The mean heart weight was 223.37 ± 57.78 g. Significant relationship between age of
the cadaver and weight of the heart (p=0.0004), weight of cadaver and weight of heart
(p=0.0001) was observed.
Conclusion: The above study provides valuable data of the heart in our geographical location,
which may be useful for cardiac surgeons and physicians.
PROSPECTIVE RANDOMIZED STUDY ON TWO DOSE FRACTIONATION REGIMENS OF HIGH DOSE RATE BRACHYTHERAPY FOR CARCINOMA CERVIX: COMPARISON OF CLINICAL RESPONSE AND COMPLICATIONS IN ORGANS AT RISK
Authors: Goswami Saurabh , Kumar Piyush , Chauhan Arvind Kumar , Nigam Jitendra , Singh D. P. 
Published: January 2018

Introduction: Cancer Cervix is treated with a combination of external beam radiotherapy and
intracavitary brachytherapy. With the recent American Brachytherapy Society consensus
guidelines for locally advanced carcinoma of the cervix, atleast Equivalent Dose 2 > 80 Gy for
patients with complete response or partial response with residual disease less than 4cm is
recommended. For non responders or those with tumors larger than 4cm at the time of
brachytherapy, tumor dose escalation to an Equivalent Dose 2 of 85-90 Gy is recommended to
point A. Present study was designed to see the feasibility of these guidelines in terms of local
tumor control and toxicities to rectum and bladder in our group of patients.
Material and Methods: Fifty patients of biopsy proven cancer cervix were enrolled. After
pre-treatment evaluation all patients were delivered external beam radiotherapy 50 Gy in 25
fractions at 200 cGy/day with concurrent cisplatin on weekly basis. Patients were then
randomized into three applications (Group A), four applications (Group B) of HDR
Brachytherapy of 6 Gy each so that total treatment time does not exceed 8 weeks. BED and
LQED were calculated and assessment of response and complications were assessed.
Statistical analysis was done using Chi square test.
Results: Mean age of the patients was 50 years. No significant hematological toxicities and
radiation reactions were seen during external beam radiotherapy. The mean BED of group A
for tumor, rectum & bladder was 137.3 Gy, 112.53 Gy & 103.23 Gy respectively and of group
B was 155.3 Gy, 120.98 Gy and 111.95 Gy respectively. The mean EQD2 in group A at tumor,
rectum & bladder was 74 Gy, 54.08 Gy and 61.94 Gy respectively and in group B was 82 Gy,
59.18 Gy and 66.60 Gy respectively. There was no statistically significant difference in local
response and early & late bladder reactions in both the groups.
Conclusion: In a follow-up of six months we did not find any significant difference in
toxicities of rectum and bladder. Long-term follow-up is needed to see for late rectal and
bladder toxicities.
ORAL MUCOSITIS IN PATIENTS OF HEAD AND NECK CANCERS TREATED WITH CHEMORADIOTHERAPY: ASSOCIATED FACTORS AND TREATMENT OUTCOME
Authors: Sharma Manish Kumar , Singh D.P. , Kumar Piyush 
Published: January 2018

Introduction: Oral Mucositis develops in nearly all patients receiving radiation therapy for
head and neck cancers. Number of risk factors has been reported to influence the frequency and
severity of Mucositis. The goal of the present study is to evaluate some of the patient and
treatment related factors which make impact on oral mucositis and also to evaluate the impact
of oral Mucositis on treatment outcome.
Material and Methods: Fifty patients were included in this study from July 2014 to June
2016. All the patients were treated with concurrent radiotherapy (70 Gy in 35 fractions in 7
weeks) and chemotherapy (Cisplatin 35 mg/m2 weekly). Clinical Response Assessment was
done as per RTOG Grading and Radiation toxicity was assessed by RTOG Acute & Late
Morbidity Scoring criteria. Statistical analysis was done using Chi Square test and Fischer
Test.
Results: In a patient population of fifty, the intensity of oral Mucositis was correlated with
various patient and treatment related factors. Patient related factors- body mass index ≤18.5
and patients taking tobacco had a higher incidence of Grade III/IV Mucositis (p<0.00 &
p=0.04 respectively). Other factors like age, gender, stage, site of disease and co morbidities
did not show statistical difference in Grade III/IV oral Mucositis. None of the treatment related
factors- total dose of Cisplatin, number of chemotherapy cycles and radiation dose showed
statistical difference in the occurrence of oral Mucositis.
Conclusion: Severe oral Mucositis leads to additional supportive care & even hospitalization.
Targeted interventions need to be developed to reduce the incidence of oral Mucositis.
Structural transformation and economic development in the best performing sub-Saharan African states
Authors: Świerczyńska Katarzyna 
Published: January 2018

Research background: Economic development in sub-Saharan Africa is of paramount importance, yet it escapes most of the attempts to understand it better in the economic dis-course, and it remains a sensitive issue in politics, contradicting stakeholders at national and international levels. The region still lags behind others in terms of technological advancement and economic development. It has grown significantly in the precedent decade, but the extent of growth has not sufficiently translated to its development. Determining strategies for sub-Saharan Africa is a scientific challenge, which requires more attention. In the globalized, interconnected reality, solving problems of the South is in the best interest of the North.
Purpose of the article: The aim of this research is to analyze structural changes as factors of economic development in the best performing sub-Saharan African countries on the grounds of new structural economics in order to provide policy implications. Methods: Namibia, Botswana, South Africa and Gabon were selected as best performing economies in the region. Based on the literature review and the analysis of descriptive statis-tics, profiles of sample countries were set. This in turn allowed to determine the potential explanatory variables for OLS model of economic development. In the model, factors relating to labour productivity, technology and structural change were included. The data was sourced from WDI (World Development Indicators) database, Gretl software was used for computations.
Findings & Value added: This paper contributes to the literature by attempting to explain structural changes in the process of economic development in the sub-Saharan region on the sample of best performing states. The paradigm of new structural economics provided theo-retical grounds for empirical analysis. Based on the results, policy implications were proposed with respect to technology promotion, natural resources management, and quality of institutions. The research was limited by data availability and reliability.
Bcl-2 Immunoexpression as Radiotherapy Response Predictor in Undifferentiated Nasopharynx Carcinoma
Authors: Damayanti Beby S. , Afiati . , Hassan Abdul H. , Hernowo Bethy S. 
Published: January 2018

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy originating from the surface of the lateral and posterior wall of the nasopharynx. Bcl-2 is an oncoprotein that plays an important role in disrupting the process of apoptosis. Expression of Bcl-2 in biopsy samples of undifferentiated NPC also related to the nature of more aggressive tumor mass and unfavorable clinical radiotherapy response. The purpose of this study was to assess the relationship of Bcl-2 expression with radiotherapy response in undifferentiated NPC. The method of this study areusing 40 samples of paraffin blocks were diagnosed as undifferentiated NPC by histopathologic examination with H&E staining. The samples were divided into 2 groups who respond and do not respond to radiotherapy. All samples examined by Bcl-2 immunohistochemistry and the expression willanalyzed and assess therelationship to radiotherapy response. Of the 40 cases of undifferentiated NPC show imunoekspresi Bcl-2 positive in 39 cases (97.5%) and 1 case (2.5%) negative from response group. The results of statistical analysis of the Bcl-2 obtained significant results with p value <0.05 so we can conclude there is a relationship between Bcl-2 expression with radiotherapy response. Conclusion, Bcl-2 can be used as a predictor for the success of radiotherapy in undifferentiated NPC. Keywords: Bcl-2, undifferentiated NPC, radiotherapy response
Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts
Authors: Anwar Ruswana , Alif Muhammad , Pribadi Adhi 
Published: January 2018

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst
The Effect of Ethanol Extract from Mangosteen Pericarps towards Parasitemia in Plasmodium berghei-Inoculated Mice
Authors: Marito Debora R. , Tjahjani Susy , Khiong Khie 
Published: January 2018

Mangosteen pericarps contains fenolic antioxidant, such as xanthone that acts as free radical scavenging substances and preventing heme polymerization. In this research we evaluated the effect of ethanolic extract of mangosteen pericarps on the parasitemia in Plasmodium berghei-inoculated mice and compared its antimalarial activity with artemisinin monotherapy in reducing the parasitemia in Plasmodium berghei-inoculated mice. Deutschland Denken Yoken (DDY) mice were randomly divided into 5 groups and inoculated by Plasmodium berghei and given 0.1 mL aquadest (KN), 0.1 mg of artemisinin (KP), 2.5 mg (E1), 0.5 mg (E2) and 0,1 mg (E3) of ethanolic extract from mangosteen pericarps in 0.1 mL aquadest in 3 days. The parasitemia was observed on one day before the treatment, namely on the first day and on the day after the last treatment. We found a highly significant decrease highly significant decrease of the parasitemia in each treatment group compared to the Negative Control group (p < 0.01), and the decrease of parasitemia level in E1 group is similar to the artemisinin monotherapy group (p < 0.05). Keywords: ethanol extract of mangosteen pericarps, artemisinin, Plasmodium berghei, malaria
Hubungan Usia Hamil dengan Kejadian Abortus di Wilayah Kerja Puskesmas Mungkid Kabupaten Magelang Tahun 2012
Authors: Ananti Yustina , Hanafi Muh. , Susilowati C.H. Sri 
Published: January 2018

Background : Abortion is more common in women aged over 30 years and increases at the age above 35 years. There is a relationship with the incidence of maternal age abortion (miscarriage) is one of the causes of bleeding that occurs in the first and second trimesters of pregnancy.
Objective : Determine the relationship of maternal age with the incidence of abortion.
Method : This research is the type of analytical survey, using a case-control design. The number of samples in this study were 77 respondents.
Results : There are maternal age relationship with the incidence of abortion in Puskesmas Mungkid Magelang Regency in the results of the x2 count of 41.627 41.627> 3.841 (Table x2) and Contingency Coefficient is equal to 0.592.
Conclusions : There are maternal age relationship with the incidence of abortion.
Pengaruh Infusa Daun Sambiloto (Andrographis paniculata Nees) Terhadap Pertumbuhan Bakteri Shigella dysenteriae Secara In Vitro
Authors: Nadifah Fitri , Fatimah Siti , Lamablawa Indah Yuliana Barekola 
Published: January 2018

Background: Bacteria Shigella dysenteriae is pathogenic bacterium which cause diarrheal diseases that enter into inside the body through intestine. Shigella dysenteriae constitute one of the gram negative bacterium which causes inflammation on intestinal, pain abdominal, tenesmus, and a bowel movements which accompanied with blood and mucus. Bad impact irational use of synthethic drugs and antibiotics can cause organ damage and germs resistance. Utilization of herbs as traditional medicine evolving rapidly and alternatively used by most. Traditional medicine has relatively low of side effect and affordable prices. Sambiloto (Andrographis paniculata Nees) is a plant which is ordinary used as a traditional medicine that can easily found around Indonesian islands. Sambiloto constitute one of the medicinal plants which is allegedly has the antibacterial effect because its chemical content of flavonoid saponins and tannin.
The objective of this study is to know the influence of sambiloto (Andrographis paniculata Nees) leaves infuse against the growth of Shigella dysenteriae bacteria.
Method: This is an experimental research using diffusion method. Statistical test who used namely analysis of variant one road (One Way anova). Analysis data were done descriptively and statistically and presented with of tables or graphs.
Results: There is influence of sambiloto leaf infusa (Andrographis paniculata Nees) against the growth of Shigella dysenteriae bacteria in vitro with a mean diameter zone of radical on concentrations the smallest 20% is 12 mm and the greatest concentration 100% is 24.3 mm.
Conclusion: Infuse leaf has a strong and positive influence in inhibit the growth of bacteria Shigella dysenteriae bacterium.
Hubungan Antara Perilaku Hidup Bersih dan Sehat dengan Kejadian Pneumonia pada Balita di Wilayah Kerja Puskesmas Mlati II Yogyakarta
Authors: Fitrianingsih Nining , Huriah Titih , Muryati Sri 
Published: January 2018

Background: The United Nations Children's Fund (UNICEF) and the World Health Organization (WHO) in 2006 stated, pneumonia is the most important child killer. Every year, more than 2 million children die from pneumonia, means that 1 in 5 infants died in the world. Health status is not only determined by health service, but the most dominant are environment and people’s behavior. One efffort to change people’s behavior, in order to support the improvement of health is by implemented of Clean And Healthy Life Behavior Program.
Aim: To know the correlation between the behavior of clean and healthy life with incident pneumonia in children in the work area of Mlati II Primary Health Center Yogyakarta.
Methods: The reseach method used an analytical survey research with cross sectional survey design. Total population in this study were 2.243 childrens, while the technical sampling is done with cluster techniques obtained as 96 samples of children. Statistical tests used chi square and than analized the relationship using Prevalence Ratio (PR).
Results:Result showed p value = 0.000 and PR = 2.88 on the relationship between the incidence of pneumonia with clean and healthy life behavior. Exclusive breastfeeding variables showed p value 0.00 and PR = 3.811. Variabel wash hand shows the results p value 0.034 and PR= 1.277. Variable smoking habits of family members is p value 0.026. and PR = 9.831.
Conclusion: There are relation between the behavior of clean and healthy life, exclusive breastfeeding, hand washing with soap and smoking habits of family members with the incidence of pneumonia.
Hubungan Pemberian Susu Formula dengan Kejadian Diare pada Bayi 0-6 Bulan di Wilayah Kerja Puskesmas Tegalrejo Kabupaten Magelang Provinsi Jawa Tengah Tahun 2013
Authors: Sari Fatimah , Rahayu Tri Budi 
Published: January 2018

Background : Babies who consume complementary feeding (MP-ASI) before the age of 6 months, are more prone of diarrhea, constipation, cough, runny nose, and heat than infants who are solely breastfed exclusively and get MP-ASI in a timely manner. When infant formula given to the baby instead of breast milk, side effects often affect with the baby's health.
Method: This research is using analytical survey method, using the approach of cross-sectional survey, to explore how health phenomenon that happens, then analyzing the dynamics of the correlation between risk factors and factor in the effects of time together. The population in this study were infants aged 0-6 months in Puskesmas Tegalrejo Magelang. Proportional sampling method with random sampling and the number of samples in this study were 79 respondents.
Results : There is a relationship between infant formula feeding with the incidence of diarrhea in infants 0-6 months infant formula given in the Work Area Health Center Tegalrejo Magelang regency with p value 0.000.
Conclusion : There is a relationship between formula feeding with diarrhea in infants 0-6 months in the given formula. In other words, formula feeding in infants 0-6 months increase the risk of diarrhea in babies.
Persentase Pediculosis capitis pada Anak Usia 9-12 Tahun di RW XI Kampung Gampingan Kota Yogyakarta
Authors: Muhajir Nurlaili Farida , Arisandi Desto , Prasetyaningsih Yuliana 
Published: January 2018

Background : Pediculosis capitis disease can be found all over the world without the restrictions of age, gender, race, economic status, and social status. Pediculosis capitis mainly affects young children and quickly spread in a dense environment such as dorm, orphanages, large cities and densely populated elementary school with bad hygiene, such behavior is rarely clean the hair. Factors that can help spread Pediculus humanus capitis infestation is socio-economic factors, level of knowledge, personal hygiene, environment, and individual characteristics (age, hair length, and hair type).
Methods : This was descriptive study. The population in this study was children who were stayed in kampung Gampingan kota Yoyakarta. Sample was taken by purposive sampling with criteria of inclusion and exclusion. The instrument used laboratory examination about Pediculus humanus capitis with direct examination. Analysis of data used univariate analysis.
Result & Conclusion : Pediculosis capitis children who have age 9-12 years in Kampung Gampingan RW XI Yogyakarta was 86.84%.
Pengaruh Infusa Daun Jambu Biji (Psidium guajava Linn.) Terhadap Pertumbuhan Bakteri Escherichia coli Secara In Vitro
Authors: Nadifah Fitri , Fatimah Siti , Susanti Lisa 
Published: January 2018

Background: Diarrhea is still a major health problem in Indonesia. This is due to the lack of knowledge about society hygiene and sanitation as well as there are still many people who haven't got health access. Guava (Psidium guajava) is a plant that has long been known by locals as traditional medicine. Some research has shown that extracts of the guava flesh is effective as an antidiarrheal. In addition, guava possessed efficacy as an anti-inflammatory, anti-mutagenic, anti-microbial and analgesic.
Objective: To determine the effect of various concentrations of guava infusion leaves inhibiting E. coli growth in vitro.
Methods: Third, fourth and fifth leaf from the tip were used as the materials. Leaves infusion concentration used was 20%, 40%, 60%, 80% and 100%. Each concentration infusion loaded into wells of Mueller-Hinton (MH) agar media. Radical zone around the wells measured as bacterial growth inhibition. The data were analyzed using one way analysis of variance (One-way ANOVAs).
Results: There is the influence of infusion of guava leaves (Psidium guajava) on the growth of E. coli in vitro with a mean diameter of the smallest concentration of radicals zone which is 20% of 15.3 mm and the greatest concentration of 100% by 22 mm.
Conclusion: Infusion of guava leaves have a strong influence in inhibiting E. coli growth as it has antibacterial chemical components.
Analisis Kualitatif Rhodamin B pada Kue Ku yang Beredar di Pasar Tradisional Kabupaten Sleman Yogyakarta
Authors: Fatimah Siti , Astuti Dian Wuri , Lestari Suryani Dwi 
Published: January 2018

Background : A food additive used to obtain food products that taste delicious, attractive, durable, easy in its distribution. Food additives that are often used in society is dye. Many fraud by producers to attract consumers such as the use of non-food grade dyes or food grade with doses exceeding the rules. Rhodamine B is a dangerous synthetic dyes are often added to foods as a dye. Kue Ku is made from a mixture of potatoes, coconut milk, glutinous rice flour, salt, sugar and red dye. The red color on my cake due to the addition of the dye rhodamine B. The use of rhodamine B can cause negative impacts on the health of consumers, thus attracting researchers to examine the presence of rhodamine B dye on my cake circulating in traditional markets Sleman, Yogyakarta.
Method : The method is a descriptive study with the aim to describe or illustrate the existence of rhodamine B on kue Ku samples circulating in traditional markets Sleman, Yogyakarta. The method used for laboratory test is by thin-layer chromatography.
Results : In this study showed 15,38% of Kue Ku samples have been investigated positive for rhodamine B.
Conclusion : There dye rhodamine B on Kue Ku circulating in traditional markets Sleman, Yogyakarta.