bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological classification of anatomical variants of the intra-articular portion of the long head of the biceps brachii tendon and analysis of the incidence and the relationship with shoulder disease for each subtype
Authors: Jeong Jeung Yeol , Park Seung Min , Park Young Eun , Yoo Jae Chul 
Published: November 2017

Purpose: Although several cases of anatomical variants of the proximal portion of the long head of the biceps brachii tendon have been reported, most are case reports on single patients; few studies have investigated the classification and incidence of this phenomenon. We aimed to classify the variants of the long head of the biceps brachii tendon by their morphology and characterize them in regard to incidence, demography, and the relationship with biceps tendon or other shoulder diseases. Methods: We retrospectively reviewed 760 arthroscopic images spanning 31 months from October 2008 and found 45 variations of the proximal portion of the long head of the biceps brachii tendon. We classified the variants using Dierickx classification system and calculated the incidence of each subtype. We investigated age, gender, bicipital morbidity rate, procedure rate, and the frequency of related shoulder disease among the variant groups using patient data and compared the groups to normal patients. Results: The overall incidence of variants was 6.5% (67.4%, mesotenon; 32.6%, adherent; 0% split (SPL); and 0% absent (ABS) type). Morbidity and procedure rates of the long head of the biceps (LHB) tendon in the variant group (27.9% and 25.6%, respectively) were lower than in the normal group (40.5% and 38.9%, respectively), but the difference was not statistically significant ( p = 0.102 and 0.082, respectively). Rotator cuff tear was significantly less common in the mesotenon (44.8%) group than in the normal group (62.4%; p = 0.004). Shoulder joint instability was more prevalent in the mesotenon (27.6%) group than in the normal group (14.9%), but the difference was not significant ( p = 0.305). The distribution of other shoulder diseases in the adherent group was similar to that in the normal group. Conclusions: The incidence of variants of the long head of the biceps brachii tendon was 6.5%, and most variants were mesotenon or adherent type. The SPL and ABS types were rare. Morbidity and procedure rates of the LHB were not significantly different between the variant group and the normal group, and rotator cuff tear was less common in the mesotenon group.
Evaluation of the Schöttle Technique in the Pediatric Knee
Authors: Huston Kellen L. , Okoroafor Ugochi C. , Kaar Scott G. , Wentt Christa L. , Saluan Paul , Farrow Lutul D. 
Published: November 2017

Background: The Schöttle point is commonly used for anatomic femoral tunnel placement during medial patellofemoral ligament (MPFL) reconstruction. This technique has not been previously validated in the skeletally immature patient, in whom femoral tunnel placement may put the distal femoral physis at risk of iatrogenic injury. Hypothesis: Interobserver reliability for femoral tunnel placement will be higher in adult knees compared with pediatric knees. Study Design: Cross-sectional study (diagnosis); Level of evidence, 3. Methods: We selected 30 perfect lateral radiographs for this study: 20 from pediatric knees (mean patient age, 10 years; range, 8-11 years) and 10 from adult knees (mean patient age, 18.5 years; range, 18-23 years). Six observers with varying levels of clinical experience evaluated each radiograph and approximated the site of the MPFL femoral tunnel using the Schöttle technique. Intra- and interobserver reliabilities for femoral tunnel placement were evaluated. Statistical analysis was used to compare measurements. Results: During initial interobserver measurements, the diameter of the composite perfect circles averaged 9.0 and 6.8 mm in adult and pediatric knees, respectively ( P = .004). At repeat measurement, circles averaged 9.8 and 7.3 mm in adult and pediatric knees, respectively ( P = .0001). Femoral tunnel placement intraobserver variance averaged 2.9 mm in adult knees (range, 1.9-4.0 mm) and 2.3 mm in pediatric knees (range, 1.9-2.9 mm). This difference was not significant ( P = .14). Conclusion: This study demonstrated that interobserver variance is actually greater in adult knees compared with pediatric knees, although interobserver variance was significantly different for both populations. Additionally, intraobserver variance is small on repeat measures, demonstrating that the Schöttle technique is reproducible for individual observers. Sources of this increased variance between observers are differences in agreement on the bony landmarks required for the Schöttle technique. Due to this variability in tunnel placement, we recommend caution when the Schöttle technique is used in pediatric knees to avoid iatrogenic injury to the distal femoral physis during femoral tunnel placement.
Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice
Authors: Zhou Yuan , Cai Wei , Zhao Zilong , Hilton Tristan , Wang Min , Yeon Jason , Liu Wei , Zhang Fangyi , Shi Fu-Dong , Wu Xiaoping , Thiagarajan Perumal , Li Min , Zhang Jianning , Dong Jing-fei 
Published: November 2017

Key PointsLactadherin promotes the clearance of circulating microvesicles through phagocytosis. Promoting microvesicle clearance prevents coagulopathy, reduces cerebral edema, and improves neurological function in severe TBI mice.
High emergency organ allocation rule in lung transplantation: a simulation study
Authors: Riou Julien , Boëlle Pierre-Yves , Christie Jason D. , Thabut Gabriel 
Published: November 2017

The scarcity of suitable organ donors leads to protracted waiting times and mortality in patients awaiting lung transplantation. This study aims to assess the short- and long-term effects of a high emergency organ allocation policy on the outcome of lung transplantation.We developed a simulation model of lung transplantation waiting queues under two allocation strategies, based either on waiting time only or on additional criteria to prioritise the sickest patients. The model was informed by data from the United Network for Organ Sharing. We compared the impact of these strategies on waiting time, waiting list mortality and overall survival in various situations of organ scarcity.The impact of a high emergency allocation strategy depends largely on the organ supply. When organ supply is sufficient (>95 organs per 100 patients), it may prevent a small number of early deaths (1 year survival: 93.7% against 92.4% for waiting time only) without significant impact on waiting times or long-term survival. When the organ/recipient ratio is lower, the benefits in early mortality are larger but are counterbalanced by a dramatic increase of the size of the waiting list. Consequently, we observed a progressive increase of mortality on the waiting list (although still lower than with waiting time only), a deterioration of patients’ condition at transplant and a decrease of post-transplant survival times.High emergency organ allocation is an effective strategy to reduce mortality on the waiting list, but causes a disruption of the list equilibrium that may have detrimental long-term effects in situations of significant organ scarcity.
Reinnervation of the diaphragm by the inferior laryngeal nerve to the phrenic nerve in ventilator-dependent tetraplegic patients with C3-5 damage
Authors: Verin Eric , Morelot-Panzini Capucine , Gonzalez-Bermejo Jesus , Veber Benoit , Perrouin Verbe Brigitte , Soudrie Brigitte , Leroi Anne Marie , Marie Jean Paul , Similowski Thomas 
Published: November 2017

The aim of this study was to evaluate the feasibility of unilateral diaphragmatic reinnervation in humans by the inferior laryngeal nerve. This pilot study included chronically ventilated tetraplegic patients with destruction of phrenic nerve motoneurons.Five patients were included. They all had a high level of tetraplegia, with phrenic nerve motor neuron destruction. They were highly dependent on ventilation, without any possibility of weaning. They did not have other chronic pathologies, especially laryngeal disease. They all had diaphragmatic explorations to diagnose the destruction of the motoneurons of the phrenic nerves and nasoendoscopy to be sure that they did not have laryngeal or pharyngeal disease. Then, surgical anastomosis of the right phrenic nerve was performed with the inferior laryngeal nerve, by a cervical approach. A laryngeal reinnervation was performed at the same time, using the ansa hypoglossi.One patient was excluded because of a functional phrenic nerve and one patient died 6 months after the surgery of a cardiac arrest. The remaining three patients were evaluated after the anastomosis every 6 months. They did not present any swallowing or vocal alterations. In these three patients, the diaphragmatic explorations showed that there was a recovery of the diaphragmatic electromyogram of the right and left hemidiaphragms after 1 year. Two patients had surgical diaphragmatic explorations for diaphragmatic pacing 18–24 months after the reinnervation with excellent results. At 36 months, none of the patients could restore their automatic ventilation.In conclusion, this study demonstrated that diaphragmatic reinnervation by the inferior laryngeal nerve is effective, without any vocal or swallowing complications.
RETRACTED ARTICLE: Normal families of solutions for modified equilibrium equations and their applications
Authors: Tan Yili , Ding Weiyong , Wang Yourong , Jiang Zongjing 
Published: November 2017

AbstractUsing boundary behaviors of solutions for certain Laplace equation proved by Yan and Ychussie (Adv. Difference Equ. 2015:226, 2015) and applying a new method to dispose of the impulsive term with finite mass subject presented by Shi and Liao (J. Inequal. Appl. 2015:363, 2015) from another point of view, we prove that there exists a supra-open in $(X,\tau)$
(
X
,
τ
)
for each $V \in\sigma$
V
∈
σ
in which the modified equilibrium equation has normal families of solutions. Moreover, we establish a new expression of a harmonic multifunction for the above equation. As applications, we not only prove the existence of normal families of solutions for modified equilibrium equations but also obtain several characterizations and fundamental properties of these new classes of superharmonic multifunctions.
Statistical methods for mechanical characterization of randomly reinforced media
Authors: Tashkinov Mikhail 
Published: November 2017

AbstractAdvanced materials with heterogeneous microstructure attract extensive interest of researchers and engineers due to combination of unique properties and ability to create materials that are most suitable for each specific application. One of the challenging tasks is development of models of mechanical behavior for such materials since precision of the obtained numerical results highly depends on level of consideration of features of their heterogeneous microstructure. In most cases, numerical modeling of composite structures is based on multiscale approaches that require special techniques for establishing connection between parameters at different scales. This work offers a review of instruments of the statistics and the probability theory that are used for mechanical characterization of heterogeneous media with random positions of reinforcements. Such statistical descriptors are involved in assessment of correlations between the microstructural components and are parts of mechanical theories which require formalization of the information about microstructural morphology. Particularly, the paper addresses application of the instruments of statistics for geometry description and media reconstruction as well as their utilization in homogenization methods and local stochastic stress and strain field analysis.
Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study
Authors: van der Tuin Karin , Mensenkamp Arjen R , Tops Carli M J , Corssmit Eleonora P M , Dinjens Winand N , van de Horst-Schrivers Anouk N , Jansen Jeroen C , de Jong Mirjam M , Kunst Henricus P M , Kusters Benno , Leter Edward M , Morreau Hans , van Nesselrooij Bernadette M P , Oldenburg Rogier A , Spruijt Liesbeth , Hes Frederik J , Timmers Henri J L M 
Published: November 2017

Abstract

Context
Paraganglioma (PGL) has the highest degree of heritability among human neoplasms. Current clinical understanding of germline SDHA mutation carriers is limited.

Objective
To estimate the contribution of SDHA mutations in PGL and to assess clinical manifestations and age-related penetrance.

Design
Nationwide retrospective cohort study.

Setting
Tertiary referral centers in the Netherlands (multicenter).

Patients
Germline SDHA analysis was performed in 393 patients with genetically unexplained PGL. Subsequently, 30 index SDHA mutation carriers and 56 nonindex carriers were studied.

Main Outcome Measures
SDHA mutation detection yield, clinical manifestations, and SDHA-related disease penetrance.

Results
Pathogenic germline SDHA variants were identified in 30 of the 393 referred patients with PGL (7.6%), who had head and neck PGL (21 of 174 [12%]), pheochromocytoma (4 of 191 [2%]), or sympathetic PGL (5 of 28 [18%]). The median age at diagnosis was 43 years (range, 17 to 81 years) in index SDHA mutation carriers compared with 52 years (range, 7 to 90 years) in nonmutation carriers (P = 0.002). The estimated penetrance of any SDHA-related manifestation was 10% at age 70 years (95% confidence interval, 0% to 21%) in nonindex mutation carriers.

Conclusion
Germline SDHA mutations are relatively common (7.6%) in patients with genetically unexplained PGL. Most index patients presented with apparently sporadic PGL. In this SDHA series, the largest assembled so far, we found the lowest penetrance of all major PGL predisposition genes. This suggests that recommendations for genetic counseling of at-risk relatives and stringency of surveillance for SDHA mutation carriers might need to be reassessed.
Differential spatial distribution of miR165/6 determines variability in plant root anatomy
Authors: Di Ruocco Giovanna , Bertolotti Gaia , Pacifici Elena , Polverari Laura , Tsiantis Miltos , Sabatini Sabrina , Costantino Paolo , Dello Ioio Raffaele 
Published: November 2017

ABSTRACT
A clear example of interspecific variation is the number of root cortical layers in plants. The genetic mechanisms underlying this variability are poorly understood, partly because of the lack of a convenient model. Here, we demonstrate that Cardamine hirsuta, unlike Arabidopsis thaliana, has two cortical layers that are patterned during late embryogenesis. We show that a miR165/6-dependent distribution of the HOMEODOMAIN LEUCINE ZIPPER III (HD-ZIPIII) transcription factor PHABULOSA (PHB) controls this pattern. Our findings reveal that interspecies variation in miRNA distribution can determine differences in anatomy in plants.
Homeodomain-interacting protein kinase promotes tumorigenesis and metastatic cell behavior
Authors: Blaquiere Jessica A. , Wong Kenneth Kin Lam , Kinsey Stephen D. , Wu Jin , Verheyen Esther M. 
Published: November 2017

ABSTRACT
Aberrations in signaling pathways that regulate tissue growth often lead to tumorigenesis. Homeodomain-interacting protein kinase (Hipk) family members are reported to have distinct and contradictory effects on cell proliferation and tissue growth. From these studies, it is clear that much remains to be learned about the roles of Hipk family protein kinases in proliferation and cell behavior. Previous work has shown that Drosophila Hipk is a potent growth regulator, thus we predicted that it could have a role in tumorigenesis. In our study of Hipk-induced phenotypes, we observed the formation of tumor-like structures in multiple cell types in larvae and adults. Furthermore, elevated Hipk in epithelial cells induces cell spreading, invasion and epithelial-to-mesenchymal transition (EMT) in the imaginal disc. Further evidence comes from cell culture studies, in which we expressed Drosophila Hipk in human breast cancer cells and showed that it enhances proliferation and migration. Past studies have shown that Hipk can promote the action of conserved pathways implicated in cancer and EMT, such as Wnt/Wingless, Hippo, Notch and JNK. We show that Hipk phenotypes are not likely to arise from activation of a single target, but rather through a cumulative effect on numerous target pathways. Most Drosophila tumor models involve mutations in multiple genes, such as the well-known RasV12 model, in which EMT and invasiveness occur after the additional loss of the tumor suppressor gene scribble. Our study reveals that elevated levels of Hipk on their own can promote both hyperproliferation and invasive cell behavior, suggesting that Hipk family members could be potent oncogenes and drivers of EMT.
A novel fluorescent reporter detects plastic remodeling of mitochondria–ER contact sites
Authors: Yang Zhaoying , Zhao Xiaocui , Xu Jiashen , Shang Weina , Tong Chao 
Published: November 2017

ABSTRACT
Mitochondria–ER contact sites (MERCs) enable communication between the ER and mitochondria and serve as platforms for many cellular events, including autophagy. Nonetheless, the molecular organization of MERCs is not known, and there is no bona fide marker of these contact sites in mammalian cells. In this study, we designed a genetically encoded reporter using split GFP protein for labeling MERCs. We subsequently analyzed its distribution and dynamics during the cell cycle and under stressful cellular conditions such as starvation, apoptosis and ER stress. We found that MERCs are dynamic structures that undergo remodeling within minutes. Mitochondrial morphology, but not ER morphology, affected the distribution of MERCs. We also found that carbonyl cyanidem-chlorophenyl hydrazone (CCCP) and oligomycin A treatment enhanced MERC formation. The stimulations that led to apoptosis or autophagy increased the MERC signal. By contrast, increasing cellular lipid droplet load did not change the pattern of MERCs.
Increased static postural sway after energy drink consumption: A randomized trial
Authors: Rosario Martin G. , Collazo Henry , Mateo Milagros , Gonzalez-Sola Maryví , Bayron Flavia 
Published: November 2017

Background: Energy drinks consumption continues to grow since its appearance in the United States in 1997. Available evidence indicates that caffeine, their main ingredient, can alter the central nervous system (CNS). However, it is unknown how energy drinks alter the CNS postural control mechanism. The purpose of this study was to investigate how energy drinks can affect postural control after sensory perturbations during stance. Methods: 20 healthy adults, (11 males; 9 females) averaging 26.1 years of age, stood on a MatScan™ pressure mat, which measured center of pressure (CoP), anteroposterior (AP) and mediolateral (ML) postural sways during eight different balance tests (BALT’s). BALT's were designed to alter or cancel the systems involved in postural control: visual, vestibular and somatosensory. Subjects were randomly assigned to a caffeine group and an energy drink group. MANOVA analysis was performed for all variables of interest. Results: In the caffeine group, the AP sway of the Eyes Closed test on a stable surface was statistically significant. In the energy drinks group, we observed a general tendency of participants to increase CoP slightly, AP and ML sway in most of the BALT’s after the consumption of an energy drink. However, this increase was not statistically significant. These results suggest that in healthy young adults, the sensory re-weighting mechanism can overcome postural perturbation and maintain overall postural control. Conclusions: We observed an overall tendency to increase postural instability after the ingestion of energy drinks.
Family-Professional Partnerships Within Schoolwide Positive Behavior Interventions and Support (SWPBIS): Preliminary Evidence for the Partnering for Positive Behavior (PPB) Meeting Strategy
Authors: Kyzar Kathleen B. , Strickland-Cohen M. Kathleen 
Published: November 2017

AbstractSchoolwide Positive Behavior Interventions and Support (SWPBIS) has been shown to be effective in improving prosocial student behaviors, which increases the likelihood of inclusive placements for students within school settings. However, to date, the SWPBIS model has lacked research-based knowledge about partnership-oriented family engagement practices that involve families and educators of students with mild to moderate problem behavior (i.e., problem behavior that does not require intensive, individualized intervention) using shared decision making to address student behavioral outcomes across home and school settings. This article reports the results of a pilot study examining Partnering for Positive Behavior (PPB), a partnership-oriented teacher-family member meeting strategy designed to address the needs of students struggling to meet classwide behavioral expectations. Participants were five educators in elementary and middle school settings. Data were analyzed utilizing a qualitative approach to generate themes. Results suggested participants and family members addressed positively stated behavioral expectations and defined them in a similar manner across the home and school settings. Overall, participants were satisfied with the PPB process, especially the strengths-based aspect of the meeting, and they judged PPB as usable and feasible given their current resources. Discussion and implications of these findings are offered.
Individual and Family Correlates of Community Living Options Among Adults With Intellectual and Developmental Disabilities
Authors: Burke Meghan M. , Lee Chung eun , Chung Moon Y. , Rios Kristina , Arnold Catherine K. , Owen Aleksa 
Published: November 2017

Abstract
With recent policy changes and case-law decisions, there are more opportunities for adults with intellectual and developmental disabilities (IDD) to live independently in inclusive settings. It is necessary to identify malleable correlates of community living options to develop interventions to increase inclusive, independent living. To this end, 546 parents and siblings of adults with IDD responded to a national survey. According to parent and sibling report, adults with IDD were more likely to live outside of the family home when the family engaged in future planning, the individual had more informal supports and more functional abilities and had parents with fewer caregiving abilities. Among the 187 adults with IDD who lived outside of the family home, individuals with more problem behaviors and fewer functional abilities were more likely to live in larger group homes (versus independently with or without supports). Further, when the family engaged in more future planning activities, adults with disabilities were more likely to live in a group home (versus independently). When parents had fewer caregiving abilities, adults with disabilities were more likely to live in bigger group homes (versus independently). Implications for policymakers, practitioners, and research are discussed.
In-corporeal diagrams: Drawing from dance to architecture
Authors: Charron Renée 
Published: November 2017

Abstract
This article is one of the offsprings of an ongoing enquiry that set out to revisit drawing’s role in architecture, by weaving a field of relations between pedagogical and epistemological theories of dance, drawing and architecture. The theories situate the affective/haptic kinaesthetic body at the centre of all in-corporeal experience, perception and conception. This article examines drawing’s potential to revive the body in architectural practices, by unveiling forces and processes that compose bodies and intertwine with the corporeality of architecture. It establishes drawing as a form of dance capable of inscribing the kinaesthetic vitality of the body into architecture. It examines architect Frank Gehry’s sketches as dynamic tracings of embodied gestures and bodily logos that mediate body and environment, interior and exterior.