bluuebunny/crossref_metadata_2025_split huggingface dataset:
The scaffold protein IQGAP1 promotes reorientation of epithelial cell polarity at the two‐cell stage for cystogenesis
Authors: Horikawa Michihiro , Hayase Junya , Kamakura Sachiko , Kohda Akira , Nakamura Masafumi , Sumimoto Hideki 
Published: October 2024

AbstractA single epithelial cell embedded in extracellular matrix (ECM) can proliferate to form an apical lumen‐harboring cyst, whose formation is a fundamental step in epithelial organ development. At an early two‐cell stage after cell division, the cell doublet typically displays “inverted” polarity, with apical and basolateral proteins being located to the ECM‐facing and cell–cell‐contacting plasma membranes, respectively. Correct cystogenesis requires polarity reorientation, a process containing apical protein endocytosis from the ECM‐abutting periphery and subsequent apical vesicle delivery to a cell–cell contact site for lumen formation. Here, we show that downstream of the ECM‐signal‐transducer β1‐integrin, Rac1, and its effector IQGAP1 promote apical protein endocytosis, contributing to polarity reorientation of mammalian epithelial Madin‐Darby canine kidney (MDCK) cells at a later two‐cell stage in three‐dimensional culture. Rac1–GTP facilitates IQGAP1 interaction with the Rac‐specific activator Tiam1, which also contributes to the endocytosis and enhances the effect of IQGAP1. These findings suggest that Tiam1 and IQGAP1 form a positive feedback loop to activate Rac1. With Rac1–GTP, IQGAP1 also binds to AP2α, an adaptor protein subunit for clathrin‐mediated endocytosis; depletion of the AP2 complex impairs apical protein endocytosis in MDCK doublets. Thus, Rac1 likely participates in polarity reorientation at the two‐cell stage via its interaction with IQGAP1.
Circular applied linguistics: A model for impactful, inclusive, and sustainable research
Authors: Jenks Christopher J. 
Published: October 2024

AbstractApplied linguists are committed to the investigation of language and real‐world problems. While this commitment leads to greater awareness of societal issues within the discipline, there are increasing pressures from societies and academic institutions to ensure that scholarship is available to, or has direct value for, the individuals and communities that are the target of our investigations. It is indeed difficult to enact social change through research when scholarship is not tailored to, and carried out with, the very individuals and communities that are being investigated. This paper attends to this opportunity by asking the following question. How do we engage in more impactful, inclusive, and sustainable research that explicitly involves the individuals and communities that we investigate? I introduce circular applied linguistics to consider the ways in which the discipline can be more impactful, inclusive, and sustainable in its research. I show how circular applied linguistics is based on the mutual benefit and shared knowledge of the researcher and the researched, creating a culture of ethical, open science, and leading to reflexive scholarship, that has greater relevance to societies.
Application of antioxidant peptide‐based coating on fresh‐cut apple
Authors: Ma Xia , Feng Jiya , Zhou Yefeng , Wang Lingling , He Yan , Zhang Hua 
Published: October 2024

SummaryFresh‐cut apples are susceptible to enzymatic browning and spoilage. The objective of this study was to evaluate the effect of different coatings on fresh‐cut apples and develop a predictive model for their shelf life. The apples were treated with antioxidant peptide from Candida utilis (CUH), carboxymethyl chitosan (CMCS), and composite coatings, and their physicochemical properties were subsequently evaluated. Key factors identified through correlation analysis of shelf life were used as input parameters for a partial least squares regression (PLSR) model to predict the shelf life of fresh‐cut apples treated with different coatings. The results indicate that CUH, CMCS, and CUH‐CMCS coatings effectively delay the deterioration of fresh‐cut apples. Notably, the CUH‐CMCS composite coating demonstrated superior performance, showing only a slight 3.50% increase in the browning index (BI) during storage. Minimal changes were observed in weight loss and firmness, while overall total acidity (TA) and pH exhibited slight decreases. Moreover, the levels of ascorbic acid (Vc), polyphenol oxidase (PPO), and peroxidase (POD) were significantly lower compared to the control group, and the total bacterial count increased by no more than 0.7 log CFU g−1. The PLSR model accurately predicted the shelf life of fresh‐cut apples treated with different coatings, with and values both exceeding 0.90. The research results indicate that the coating and model developed in this study offer a novel approach for preserving and managing fresh‐cut apples.
Investigation of Hemorheological Parameters in Ischemic Stroke Patients
Authors: Uygun Gursan Gunes , Caglar Sena Ebru , Tutkavul Kemal , Kosem Esra Gurdal , Karakoc Yunus 
Published: October 2024

ABSTRACTBackgroundThe aim of this study is to determine whether there are any changes in hemorheological parameters, including whole blood viscosity (WBV), plasma viscosity, erythrocyte aggregation, and erythrocyte deformability, in acute ischemic stroke patients, and to establish their relationship with stroke etiology. The study also aims to observe the changes in these parameters, if any, over time and after treatment, and to assess the correlation between risk factors for ischemic stroke and neuroimaging findings.MethodsThis was a prospective observational study including 70 patients diagnosed with acute ischemic stroke within the first 3 days of the onset of symptoms and 96 healthy controls. Stroke patients were categorized based on TOAST criteria, and hemorheological parameters were measured at admission and on the fifth day post‐treatment. Erythrocyte aggregation and deformability were measured using a laser ektacytometer, and viscosity assessment was conducted with a rotational viscometer.ResultsStroke patients exhibited significant differences from the control group in aggregation amplitude, aggregation index, and aggregation half‐time (p = 0.001, p = 0.013, p = 0.009, respectively) and showed elevated maximum value of elongation index (p = 0.000). No significant differences in WBV and plasma viscosity were observed between the groups. Post‐treatment, the small vessel occlusion subgroup demonstrated a notable reduction in WBV. Additionally, homocysteine levels showed a positive correlation with scattered white matter lesions in basal ganglia and infratentorial regions (p = 0.002, p = 0.039, respectively).ConclusionsIncreased predisposition to erythrocyte aggregation may contribute to the occurrence of acute ischemic stroke. Moreover, gaining the ability of erythrocytes to deform and increase blood flow may serve as a compensatory mechanism in the chronic vascular disease process. The risk factors for ischemic stroke may exhibit connections to specific areas within the brain.
Tissue adhesives for closure of intraoral surgical incisions: A systematic review and meta‐analysis
Authors: Medeiros Inês , Pascoal Selma , Castro Filipe , Macedo José Paulo , Lopes Otília , Pereira Jorge 
Published: October 2024

AbstractSurgical success includes a planned incision, achieving haemostasis, good mechanical closure and optimal maintenance of the surgical wound. New materials, as tissue adhesives, have been suggested as substitutes for sutures, to overcome their disadvantages. This study aimed at gathering the differences of using surgical adhesives in oral surgery compared with the conventional method of using sutures as a wound closure technique. PRISMA analyses, PICO criteria and PubMed/Medline database, EBSCO and Cochrane Library were used for research. Inclusion criteria included prospective, randomized controlled trials and case–control studies published in English with full access, where clinical advantages and demerits/limitations were reported in patients who underwent oral surgical incisions, without time restrictions. Exclusion criteria comprised literature with lower level of evidence. A total of 15 studies were assessed and analysed 15 parameters as alternatives to sutures (100%), cost‐effectiveness (6,6%), postoperative pain (53,3%), time consumption (73,3%), haemostasis (46,6%), homeostasis (13,3%), aids healing (26,6%), tissue inflammation (26,6%), safety (6,6%), graft dimension (3,13), biocompatibility (13,3%), adhesion to tissue (6,6%), bacteriostatic effect (20%), oedema (13,3%) and ease of application (26,6). Selected articles' results indicate that surgical glues can be a suitable alternative and/or adjuvant to oral sutures, presenting numerous advantages.
Microstructural basis of AI predictions for material properties: A case study of silicon nitride ceramics using t‐SNE
Authors: Furushima Ryoichi , Nakashima Yuki , Maruyama Yutaka , Zhou You , Hirao Kiyoshi , Ohji Tatsuki , Fukushima Manabu 
Published: October 2024

AbstractArtificial intelligence (AI) models such as a convolutional neural network (CNN) are powerful tools for predicting the properties of materials from their microstructural images, etc. It is, however, critically essential to understand how the AI models use images and information to predict the target properties. In this study, we tried to gain insight into the inner workings of two AI models trained to predict bending strength (BS) and thermal conductivity (TC) of silicon nitride ceramics. Focusing on the intermediate feature representation of the microstructural images in the networks, the high‐dimensional data points corresponding to sample images were mapped onto a two‐dimensional plane using t‐distributed stochastic neighbor embedding (t‐SNE). The maps demonstrated that the AI models predicted BS and TC primarily based on the porosity and grain sizes of the samples. The result indicates that t‐SNE is a useful technique for making the basis of models' predictions more understandable and well founded.
Reptile Diversity Patterns Under Climate and Land Use Change Scenarios in a Subtropical Montane Landscape in Mexico
Authors: Ramírez‐Arce Daniel G. , Ochoa‐Ochoa Leticia M. , Lira‐Noriega Andrés , Martorell Carlos 
Published: October 2024

ABSTRACTAimMountainous regions are rich in reptile biodiversity but face threats from climate and land use changes. Understanding how these factors affect reptile diversity in these regions can highlight key conservation hotspots that require effective conservation actions. Here, we explored reptile taxonomic and functional diversity patterns along the Sierra Madre del Sur region in southeast Mexico, and potential changes in future years caused by different climate and land use change scenarios.LocationSierra Madre del Sur, México.TaxonReptiles.MethodsWe used species distribution models and information on species traits to estimate taxonomic and functional diversity throughout the Sierra Madre del Sur (SMS) region under current and future climate and land use change scenarios.ResultsGreater taxonomic and functional diversity was observed in both temperate and tropical forests. Taxonomic diversity was higher in more drier areas at high elevations while higher functional diversity was observed in wetter areas at intermediate‐to‐high elevations. Lower diversity for both dimensions was associated with anthropic land uses. In future scenarios, both dimensions of diversity are expected to increase in temperate forest in highlands of central Oaxaca and decrease in the southcentral portion of the SMS, particularly for the worst scenarios due to increased deforestation rates.Main ConclusionsHigher taxonomic diversity in more drier areas at high elevations could be due to historical and evolutionary factors, while higher functional diversity in wetter areas at intermediate‐to‐high elevations may be explained by a higher environmental heterogeneity in forests within these conditions. Larger diversity losses in the southcentral portion of the SMS are probably due to larger predicted deforestation rates in those areas. Our results are valuable not just for informing conservation actions, such as the creation of protected natural areas but also to understand the underlying processes behind the patterns of reptile diversity.
The impact of biodiversity information on willingness to pay
Authors: Hörisch Jacob , Petersen Lars , Jacobs Kathleen 
Published: October 2024

AbstractBiodiversity loss is one of the planetary boundaries that is most urgently in need of action. However, very little is known about the consumers’ willingness to pay (WTP) for products with higher (or lower) levels of biodiversity performance. Therefore, this research was conducted to investigate how consumers’ WTP is influenced by a product's impact on biodiversity. To address this question, we collected representative data from 524 German consumers in a survey‐based experiment. Drawing on prospect theory, we identified the shape of the WTP reaction function for a given product in relation to its biodiversity performance. We demonstrate that consumers with sufficiently high levels of education and concern about biodiversity loss are willing to pay more for products with above‐average biodiversity performance and less for products with below‐average biodiversity performance. However, the extent to which a product outperforms the industry average does not influence consumers’ increased WTP. From a sustainable development perspective, these observed patterns highlight the problematic contrast between the pressing need for substantial improvements in product biodiversity performance and the limited incentives provided by consumers. Consequently, the findings suggest that the incentives that consumers currently provide for corporate biodiversity management are insufficient to assist in staying within the planetary boundaries.
Sustainability of bio‐based polyethylene: The influence of biomass sourcing and end‐of‐life
Authors: Ritzen Linda , Sprecher Benjamin , Bakker Conny , Balkenende Ruud 
Published: October 2024

AbstractBio‐based polymers may present a sustainable, circular way to reduce the environmental impact of plastics because they are produced from biomass that absorbs CO2 during its growth. However, sourcing (type of biomass used and cultivation location), production, and end‐of‐life affect the environmental impact of bio‐based plastics. We assessed the effect of sourcing and end‐of‐life options on the environmental impact of bio‐based high‐density polyethylene (bio‐HDPE) in 31 sourcing scenarios and five end‐of‐life options. Our study found that careful consideration of biomass sourcing (biomass type and production location) and end‐of‐life is needed to optimize the environmental impact of bio‐based plastics. If these aspects are not considered, the environmental impact of bio‐HDPE may exceed that of its petrochemical‐based counterpart. The direct availability of fermentable sugars indicated a lower environmental impact. The production location affected the resources needed for biomass cultivation and the environmental impact of processing due to the energy mix. Recently published guidelines do not allow biogenic carbon to be accounted for during the production stage, but only upon the incineration of the plastic. Our results show that this way of attributing biogenic carbon results in an apparent disadvantage for bio‐based plastics compared to petrochemical‐based plastics. Furthermore, it disadvantaged mechanical recycling of bio‐based plastics compared to incineration, a result out of line with circular economy principles.
Assessing the prospective environmental impacts and circularity potentials of building stocks: An open‐source model from Austria (PULSE‐AT)
Authors: Alaux Nicolas , Schwark Benedict , Hörmann Marius , Ruschi Mendes Saade Marcella , Passer Alexander 
Published: October 2024

AbstractBuilding stock models can provide information on the current and future environmental impacts of buildings. Therefore, these models are useful tools for identifying trajectories that are compatible with the objectives of the Paris Agreement. However, the models often lack detail, which can lead to underestimations of the actual impacts of national building stocks, resulting in misinformed decision‐making. This study presents the steps needed to create an archetype‐based bottom‐up building stock model that uses Python and Brightway2. Prospective environmental assessments, including circularity assessments, can be performed by combining life cycle assessment (LCA) with material flow analysis (MFA). An important facet of this model is that it supports the development of a practical and easily reproducible method for the high‐precision modeling of a building stock. This model is open source, is readily adaptable to other countries, and does not require programming knowledge. This combined LCA‐MFA method can be used to assess the potential to reduce greenhouse gas (GHG) emissions from the Austrian building stock in five future scenarios involving sufficiency, energy, material, and design‐related measures. The results show different reduction potentials for embodied and operational GHG emissions depending on the set of measures taken. In all scenarios, mineral and synthetic materials contribute the most to embodied GHG emissions. Finally, the issue of validating building stock models is addressed, and numerous cross‐evaluations are proposed to ensure the reliability of results.
Resolving complexity: Material flow analysis of a national wood flow system integrating the versatility of wood
Authors: Malinverno Nadia , Buschor Simon , Vogel Kealie , Schwarze Francis , Stadelmann Golo , Thürig Esther , Nowack Bernd , Nyström Gustav , Som Claudia 
Published: October 2024

AbstractA systemic understanding of the use of wood resources is required to defossilize society and promote bio‐based developments. This study provides a novel approach to represent a comprehensive material flow analysis (MFA) spanning the entire wood value chain; encompassing wood harvest to products, use in society, collection, reuse, recycle, energy generation, and trade. By recognizing wood as a complex material, with changing properties throughout its lifespan, we developed a method where we employed a color‐coded system for processes (27 boxes) and 110 flows to symbolize distinct life stages and the dynamic characteristics, including 23 different trade flows. The wood processes and flows are categorized (11 categories) into different wood types (e.g., softwood and hardwood) and harmonized to include all available data on each single step of the wood life cycle, improving data traceability and visualization, and allowing for replicable analysis with respective data noted for each process and flow. Methodological obstacles due to different units, uncertainty of flows, and discrepancies in data are addressed and adjustments proposed. Switzerland was chosen as a case study as a large number of various types of data were available to perform the analysis. The categorized and harmonized flows of woody biomass mapped and analyzed in the MFA provide a comprehensive basis to identify and recommend avenues to increase cascading use of wood as a carbon sink, by considering relevant aspects like the network of flows and processes, the quality and availability of the woody biomass, and the organization of the industry.
From schools of thought to an ecology of practices: Categorizing circular economy's futures
Authors: Nolan Ryan , Morasae Esmaeil Khedmati , Michael Mike 
Published: October 2024

AbstractIn response to pressing societal challenges, scholars are increasingly focusing on research aimed at fostering sustainable futures. We contribute to that discussion by theorizing the circular economy (CE) as an “ecology of practices.” The ecology of practices concept helps to make sense of a developing field that has been heavily practitioner‐driven. Through an analysis of the diverse CE practices in analytical and operational contexts, we investigate the roles, disciplinary influences, and visions for the future and categorize their trajectories. Drawing on the sociology of expectations, we consider the articulations of CE in practice, advocating for inclusive dialogue among stakeholders and collective engagement with ontological multiplicity in shaping CE futures. We propose a framework that contributes to broader debates in organization and management studies, emphasizing the significance of everyday practices in shaping sustainable futures beyond the realm of CE. In so doing, we focus on unpicking how sustainable futures are variously enacted as a way of enabling collaboration that might otherwise be hindered by disciplinary obligations.
Raising relational legal consciousness through co‐production research? Making law more accessible
Authors: HARDING ROSIE , KEELING AMANDA 
Published: October 2024

AbstractThis article offers co‐production as a new methodology for relational approaches to legal consciousness studies that allows for deeper analysis of and engagement with the everyday experience of law. We argue that the inherent relationality of co‐production has the potential to both expose and change legal consciousness. As an approach that equalizes status in the co‐production of knowledge, social structures and hierarchies are reproduced in real time, allowing the relational networks through which legal consciousness is formed to emerge. We demonstrate both the possibility and the value of this approach through a discussion of early findings from a co‐produced project focused on accessible legal information for disabled people with cognitive impairments. Our emerging data show that disabled people's experience as ‘outsiders’ in their communities, and the barriers to justice that they encounter through being not believed or information being given in inaccessible formats, creates uncertainty and distrust of the utility of legal professionals as routes for resolution – even as they express a desire for formal legal process. These data also show that engaging with co‐production work can increase the legal confidence of people from marginalized groups.