bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binding of Chromium(III) to Transferrin Could Be Involved in Detoxification of Dietary Chromium(III) Rather than Transport of an Essential Trace Element
Authors: Levina Aviva , Pham T. H. Nguyen , Lay Peter A. 
Published: May 2016

AbstractCrIII binding to transferrin (Tf; the main FeIII transport protein) has been postulated to mediate cellular uptake of CrIII to facilitate a purported essential role for this element. Experiments using HepG2 (human hepatoma) cells, which were chosen because of high levels of the transferrin receptor, showed that CrIII binding to vacant FeIII‐binding sites of human Tf effectively blocks cellular CrIII uptake. Through bio‐layer interferometry studies of the Tf cycle, it was found that both exclusion and efflux of Cr2IIITf from cells was caused by 1) relatively low Cr2Tf affinity to cell‐surface Tf receptors compared to Fe2Tf, and 2) disruption of metal release under endosomal conditions and post‐endosomal Tf dissociation from the receptor. These data support mounting evidence that CrIII is not essential and that Tf binding is likely to be a natural protective mechanism against the toxicity and potential genotoxicity of dietary Cr through blocking CrIII cellular accumulation.
A Finite Frequency Approach to H∞ Filtering for T–S Fuzzy Systems with Unknown Inputs
Authors: Chibani Ali , Chadli Mohammed , Braiek Naceur Benhadj 
Published: May 2016

AbstractThis paper deals with the problem of state estimation of T–S fuzzy systems subject to unknown inputs. The proposed observer is designed in finite frequency domain to reduce the conservatism generated by those designed in the entire frequency domain when the unknown input frequency ranges are known beforehand. First, a finite frequency H∞ index is introduced to measure the robustness against unknown inputs. Then, design conditions are derived in linear matrix inequality terms. Finally, an illustrative example is introduced to check the developed methodology.
Rhodium‐Catalyzed Methanation and Methane Steam Reforming Reactions on Rhodium–Perovskite Systems: Metal–Support Interaction
Authors: Thalinger Ramona , Götsch Thomas , Zhuo Chen , Hetaba Walid , Wallisch Wolfgang , Stöger‐Pollach Michael , Schmidmair Daniela , Klötzer Bernhard , Penner Simon 
Published: May 2016

AbstractMetal–support interaction in rhodium–perovskite systems was studied using LSF (La0.6Sr0.4FeO3−δ) and STF (SrTi0.7Fe0.3O3−δ) supports to disentangle different manifestations of strong or reactive metal–support interaction. Electron microscopy and catalytic characterization in methane steam reforming/CO2 methanation reveal that reduction in hydrogen at 673 K and 873 K causes different extents of Fe exsolution. Depending on the perovskite reducibility, Fe–Rh alloy particles are observed. No signs of strong metal–support interaction (i.e., encapsulation of metal particles) by reduced oxide species were observed. As re‐oxidation in oxygen at 873 K did not fully restore the initial structures, the interaction between Rh and the perovskites manifests itself in irreversible alloy formation. Catalytic effects are the suppression of methane reactivity with increasing prereduction temperature. The results show the limits of the strong metal–support interaction concept in complex metal–oxide systems.
A Two‐Component Alkyne Metathesis Catalyst System with an Improved Substrate Scope and Functional Group Tolerance: Development and Applications to Natural Product Synthesis
Authors: Schaubach Sebastian , Gebauer Konrad , Ungeheuer Felix , Hoffmeister Laura , Ilg Marina K. , Wirtz Conny , Fürstner Alois 
Published: May 2016

AbstractAlthough molybdenum alkylidyne complexes such as 1 endowed with triarylsilanolate ligands are excellent catalysts for alkyne metathesis, they can encounter limitations when (multiple) protic sites are present in a given substrate and/or when forcing conditions are necessary. In such cases, a catalyst formed in situ upon mixing of the trisamidomolybenum alkylidyne complex 3 and the readily available trisilanol derivatives 8 or 11 shows significantly better performance. This two‐component system worked well for a series of model compounds comprising primary, secondary or phenolic ‐OH groups, as well as for a set of challenging (bis)propargylic substrates. Its remarkable efficiency is also evident from applications to the total syntheses of manshurolide, a highly strained sesquiterpene lactone with kinase inhibitory activity, and the structurally demanding immunosuppressive cyclodiyne ivorenolide A; in either case, the standard catalyst 1 largely failed to effect the critical macrocyclization, whereas the two‐component system was fully operative. A study directed toward the quinolizidine alkaloid lythrancepine I features yet another instructive example, in that a triyne substrate was metathesized with the help of 3/11 such that two of the triple bonds participated in ring closure, while the third one passed uncompromised. As a spin‐off of this project, a much improved ruthenium catalyst for the redox isomerization of propargyl alcohols to the corresponding enones was developed.
Peer‐counseling for women newly diagnosed with breast cancer: A randomized community/research collaboration trial
Authors: Giese‐Davis Janine , Bliss‐Isberg Caroline , Wittenberg Lynne , White Jennifer , Star Path , Zhong Lihong , Cordova Matthew J. , Houston Debra , Spiegel David 
Published: May 2016

BACKGROUNDWe conducted a randomized controlled trial of peer‐counseling for newly diagnosed breast cancer (BC) patients as a community/research collaboration testing an intervention developed jointly by a community‐based‐organization serving women with cancer and university researchers.METHODSWe recruited 104 women newly diagnosed with BC at any disease stage. Prior to randomization, all received a one‐time visit with an oncology nurse who offered information and resources. Afterwards, we randomized half to receive a match with a Navigator with whom they could have contact for up to 6 months. We recruited, trained, and supervised 30 peer counselors who became “Navigators.” They were at least one‐year post‐diagnosis with BC. Controls received no further intervention. We tested the effect of intervention on breast‐cancer–specific well‐being and trauma symptoms as primary outcomes, and several secondary outcomes. In exploratory analyses, we tested whether responding to their diagnosis as a traumatic stressor moderated outcomes.RESULTSWe found that, compared with the control group, receiving a peer‐counseling intervention significantly improved breast‐cancer–specific well‐being (p=0.01, Cohen's d=0.41) and maintained marital adjustment (p=0.01, Cohen's d=0.45) more effectively. Experiencing the diagnosis as a traumatic stressor moderated outcomes: those with a peer counselor in the traumatic stressor group improved significantly more than controls on well‐being, trauma and depression symptoms, and cancer self‐efficacy.CONCLUSIONSHaving a peer counselor trained and supervised to recognize and work with trauma symptoms can improve well‐being and psychosocial morbidity during the first year following diagnosis of BC. Cancer 2016;122:2408–2417. © 2016 American Cancer Society.
Clinical and molecular markers of long‐term survival after oligometastasis‐directed stereotactic body radiotherapy (SBRT)
Authors: Wong Anthony C. , Watson Sydeaka P. , Pitroda Sean P. , Son Christina H. , Das Lauren C. , Stack Melinda E. , Uppal Abhineet , Oshima Go , Khodarev Nikolai N. , Salama Joseph K. , Weichselbaum Ralph R. , Chmura Steven J. 
Published: May 2016

BACKGROUNDThe selection of patients for oligometastasis‐directed ablative therapy remains a challenge. The authors report on clinical and molecular predictors of survival from a stereotactic body radiotherapy (SBRT) dose‐escalation trial for oligometastases.METHODSPatients who had from 1 to 5 metastases, a life expectancy of >3 months, and a Karnofsky performance status of >60 received escalating SBRT doses to all known cancer sites. Time to progression, progression‐free survival, and overall survival (OS) were calculated at the completion of SBRT, and clinical predictors of OS were modeled. Primary tumor microRNA expression was analyzed to identify molecular predictors of OS.RESULTSSixty‐one evaluable patients were enrolled from 2004 to 2009. The median follow‐up was 2.3 years for all patients (range, 0.2‐9.3 years) and 6.8 years for survivors (range, 2.0‐9.3 years). The median, 2‐year, and 5‐year estimated OS were 2.4 years, 57%, and 32%, respectively. The rate of progression after SBRT was associated with an increased risk of death (hazard ratio [HR], 1.44; 95% confidence interval [CI], 1.24‐1.82). The time from initial cancer diagnosis to metastasis (HR, 0.98; 95% CI, 0.98‐0.99), the time from metastasis to SBRT (HR, 0.98; 95% CI, 0.98‐0.99), and breast cancer histology (HR, 0.12; 95% CI, 0.07‐0.37) were significant predictors of OS. In an exploratory analysis, a candidate classifier using expression levels of 3 microRNAs (miR‐23b, miR‐449a, and miR‐449b) predicted survival among 17 patients who had primary tumor microRNA expression data available.CONCLUSIONSA subset of oligometastatic patients achieves long‐term survival after metastasis‐directed SBRT. Clinical features and primary tumor microRNA expression profiling, if validated in an independent dataset, may help select oligometastatic patients most likely to benefit from metastasis‐directed therapy. Cancer 2016;122:2242–50. © 2016 American Cancer Society.
Double epigenetic modulation of high‐dose chemotherapy with azacitidine and vorinostat for patients with refractory or poor‐risk relapsed lymphoma
Authors: Nieto Yago , Valdez Benigno C. , Thall Peter F. , Jones Roy B. , Wei Wei , Myers Alan , Hosing Chitra , Ahmed Sairah , Popat Uday , Shpall Elizabeth J. , Qazilbash Muzaffar , Gulbis Alison , Anderlini Paolo , Shah Nina , Bashir Qaiser , Alousi Amin , Oki Yasuhiro , Fanale Michelle , Dabaja Bouthaina , Pinnix Chelsea , Champlin Richard , Andersson Borje S. 
Published: May 2016

BACKGROUNDMore active high‐dose chemotherapy (HDC) regimens are needed for refractory lymphomas. The authors previously combined infusional gemcitabine with busulfan and melphalan (Gem/Bu/Mel) pursuing DNA damage repair inhibition. Subsequently, they combined Gem/Bu/Mel with vorinostat, which facilitates chemotherapy access to DNA. The resulting regimen was safe and synergistic. However, vorinostat induced DNA methyltransferase up‐regulation, which could be preclinically abrogated by azacitidine, increasing tumor‐cell kill. Those observations led to a clinical combination of azacitidine with vorinostat/Gem/Bu/Mel.METHODSPatients ages 12 to 65 years with refractory or poor‐risk relapsed lymphomas were eligible. They received intravenous azacitidine on days −11 through −3 at doses from 15 to 35 mg/m2 daily (dose levels 1‐3), followed by oral vorinostat (1000 mg once daily on days −11 through −3), gemcitabine (2775 mg/m2 over 4.5 × 2), busulfan (at an area under the receiver operating characteristic curve of 4000 daily × 4), and melphalan (60 mg/m2 × 2). Patients who had tumors that were positive for CD20 (cluster of differentiation 20; B‐lymphocyte antigen) received rituximab on day −9.RESULTSIn total, 60 patients were enrolled, including 26 with diffuse large B‐cell lymphoma (DLBCL) (10 double hit/double expressors), 21 with Hodgkin lymphoma, 8 with T‐cell lymphoma, and 5 with other B‐cell lymphomas. The median patient age was 41 years (range, 16‐65 years), patients had received a median of 3 prior lines of chemotherapy (range, 2‐7 lines of chemotherapy); and 32% of tumors were positive on positron emission tomography studies at the time of HDC. Two patients died from treatment complications (respiratory syncytial virus pneumonia and sepsis, respectively). The maximum tolerated dose of azacitidine was encountered at dose level 1 (15 mg/m2 daily). The toxicity profile (mainly mucositis and dermatitis) was manageable and was identical to that of vorinostat/Gem/Bu/Mel. Neutrophils and platelets engrafted promptly. At a median follow‐up of 15 months (range, 8‐27 months), the event‐free and overall survival rates were 65% and 77%, respectively, among patients with DLBCL; 76% and 95%, respectively, among patients with Hodgkin lymphoma; and 88% for both among patients with T‐cell lymphoma.CONCLUSIONSDouble epigenetic modulation of Gem/Bu/Mel with azacitidine/vorinostat is feasible and highly active in patients with refractory/poor‐risk relapsed lymphomas, warranting further evaluation. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2680–2688. © 2016 American Cancer Society.
Extraocular motoneuron pools develop along a dorsoventral axis in zebrafish, Danio rerio
Authors: Greaney Marie R. , Privorotskiy Ann E. , D'Elia Kristen P. , Schoppik David 
Published: May 2016

ABSTRACTBoth spatial and temporal cues determine the fate of immature neurons. A major challenge at the interface of developmental and systems neuroscience is to relate this spatiotemporal trajectory of maturation to circuit‐level functional organization. This study examined the development of two extraocular motor nuclei (nIII and nIV), structures in which a motoneuron's identity, or choice of muscle partner, defines its behavioral role. We used retro‐orbital dye fills, in combination with fluorescent markers for motoneuron location and birthdate, to probe spatial and temporal organization of the oculomotor (nIII) and trochlear (nIV) nuclei in the larval zebrafish. We describe a dorsoventral organization of the four nIII motoneuron pools, in which inferior and medial rectus motoneurons occupy dorsal nIII, while inferior oblique and superior rectus motoneurons occupy distinct divisions of ventral nIII. Dorsal nIII motoneurons are, moreover, born before motoneurons of ventral nIII and nIV. The order of neurogenesis can therefore account for the dorsoventral organization of nIII and may play a primary role in determining motoneuron identity. We propose that the temporal development of extraocular motoneurons plays a key role in assembling a functional oculomotor circuit. J. Comp. Neurol. 525:65–78, 2017. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
An adaptive color similarity function suitable for image segmentation and its numerical evaluation
Authors: Alvarado‐Cervantes Rodolfo , Felipe‐Riverón Edgardo M. , Khartchenko Vladislav , Pogrebnyak Oleksiy 
Published: May 2016

AbstractIn this article, we present an adaptive color similarity function defined in a modified hue‐saturation‐intensity color space, which can be used directly as a metric to obtain pixel‐wise segmentation of color images among other applications. The color information of every pixel is integrated as a unit by an adaptive similarity function thus avoiding color information scattering. As a direct application we present an efficient interactive, supervised color segmentation method with linear complexity respect to the number of pixels of the input image. The process has three steps: (1) Manual selection of few pixels in a sample of the color to be segmented. (2) Automatic generation of the so called color similarity image (CSI), which is a gray level image with all the gray level tonalities associated with the selected color. (3) Automatic threshold of the CSI to obtain the final segmentation. The proposed technique is direct, simple and computationally inexpensive. The evaluation of the efficiency of the color segmentation method is presented showing good performance in all cases of study. A comparative study is made between the behavior of the proposed method and two comparable segmentation techniques in color images using (1) the Euclidean metric of thea* andb* color channels rejectingL* and (2) a probabilistic approach ona* andb* in the CIE L*a*b* color space. Our testing system can be used either to explore the behavior of a similarity function (or metric) in different color spaces or to explore different metrics (or similarity functions) in the same color space. It was obtained from the results that the color parametersa* andb* are not independent of the luminance parameterL* as one might initially assume in the CIE L*a*b* color space. We show that our solution improves the quality of the proposed color segmentation technique and its quick result is significant with respect to other solutions found in the literature. The method also gives a good performance in low chromaticity, gray level and low contrast images. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 156–172, 2017
The method of dynamic mode decomposition in shallow water and a swirling flow problem
Authors: Bistrian Diana A. , Navon Ionel M. 
Published: May 2016

SummaryIn this paper, a new vector‐filtering criterion for dynamic modes selection is proposed that is able to extract dynamically relevant flow features from dynamic mode decomposition of time‐resolved experimental or numerical data. We employ a novel modes selection criterion in parallel with the classic selection based on modes amplitudes, in order to analyze which of these procedures better highlight the coherent structures of the flow dynamics. Numerical tests are performed on two distinct problems. The efficiency of the proposed criterion is proved in retaining the most influential modes and reducing the size of the dynamic mode decomposition model. By applying the proposed filtering mode technique, the flow reconstruction error is shown to be significantly reduced. Copyright © 2016 John Wiley & Sons, Ltd.
A Hybrid Monte‐Carlo sampling smoother for four‐dimensional data assimilation
Authors: Attia Ahmed , Rao Vishwas , Sandu Adrian 
Published: May 2016

SummaryThis paper constructs an ensemble‐based sampling smoother for four‐dimensional data assimilation using a Hybrid/Hamiltonian Monte‐Carlo approach. The smoother samples efficiently from the posterior probability density of the solution at the initial time. Unlike the well‐known ensemble Kalman smoother, which is optimal only in the linear Gaussian case, the proposed methodology naturally accommodates non‐Gaussian errors and nonlinear model dynamics and observation operators. Unlike the four‐dimensional variational method, which only finds a mode of the posterior distribution, the smoother provides an estimate of the posterior uncertainty. One can use the ensemble mean as the minimum variance estimate of the state or can use the ensemble in conjunction with the variational approach to estimate the background errors for subsequent assimilation windows. Numerical results demonstrate the advantages of the proposed method compared to the traditional variational and ensemble‐based smoothing methods. Copyright © 2016 John Wiley & Sons, Ltd.
Option Pricing Under Skewness and Kurtosis Using a Cornish–Fisher Expansion
Authors: Aboura Sofiane , Maillard Didier 
Published: May 2016

AbstractThis paper revisits the pricing of options, in a context of financial stress, when the underlying asset's returns displays skewness and excess kurtosis. For that purpose, we use a Cornish–Fisher transformation for valuing option contracts with an exact formula allowing for heavy‐tails. An application to the S&P 500 stock index option contracts is carried out during both stress (October 2008) and calm (May 2015) periods. It provides evidence about the capability of the Cornish–Fisher model to fairly price options during a period of stress without violating the skewness–kurtosis boundaries given its large domain of validity. © 2016 Wiley Periodicals, Inc. Jrl Fut Mark 36:1194–1209, 2016
Climate change impacts on agricultural non‐point source pollution with consideration of uncertainty in CMIP5
Authors: Cho Jaepil , Oh Chansung , Choi Junghoon , Cho Youngkweon 
Published: May 2016

AbstractChanges in non‐point source pollutant loads in the Mankyeong River Basin for the 30‐year future period (2011–2040) were assessed with consideration of the uncertainties in the climate change scenario data. The downscaled weather variables from eleven Climate Models for the Representative Concentration Pathways (RCP) 8.5 scenario were used as input to the calibrated and validated Soil and Water Assessment Tool (SWAT) model for simulating the changes of future NPS pollutant loads. The bias‐corrected data appropriately reproduced the spatial and temporal patterns of the NPS pollutant load, which was derived by using observed weather data. The rates of change in sediment, total nitrogen (TN) and total phosphorus (TP) loads within each sub‐basin under the RCP8.5 future scenario showed an average increase of 13.1 to 143%, −13.4 to 49.5%, and 0.40 to 128%, respectively. It can be concluded that sediment and TP loads are sensitive to changes in the characteristics of climate variables by showing an increase trend in most of the sub‐basins. Looking at the temporal distribution, the uncertainty ranges for both sediment and TP were higher during the wet season from June to September. Copyright © 2016 John Wiley & Sons, Ltd.
Influence of deficit irrigation on strawberry (Fragaria × ananassa Duch.) fruit quality
Authors: Weber Nika , Zupanc Vesna , Jakopic Jerneja , Veberic Robert , Mikulic‐Petkovsek Maja , Stampar Franci 
Published: May 2016

AbstractBACKGROUNDThree different irrigation regimes – upper limit of field capacity (UFC), −12 kPa); lower limit of field capacity (LFC), −33 kPa; and deficit irrigation (DI), −70 kPa) were established on silty‐loam soil and monitored with tensiometers. Yield and fruit quality of ‘Flamenco’ and ‘Eva's Delight’ ever‐bearing strawberry cultivars were monitored. The aim of the study was to evaluate the effect of different irrigation regimes on the content of sugars, organic acids and phenolic compounds using high‐performance liquid chromatography–mass spectrometry HPLC/HPLC‐MS.RESULTSDeficit irrigation significantly increased the content of sugars (from 1.1‐ to 1.3 fold), organic acids (from 1.1‐ to 1.3‐fold), their ratio (from 1.1‐ to 1.2‐fold) and the content of most identified phenolics in cv. ‘Flamenco’. Conversely, higher amounts of total sugars and organic acids (1.7‐ to 1.8‐fold) were detected in ‘Eva's Delight’ strawberries at UFC and LFC irrigation. Deficit irrigation generally decreased strawberry yield of cv. ‘Eva's Delight’.CONCLUSIONThe results suggest superior fruit quality and taste of strawberries grown under minor deficit irrigation for cv. ‘Flamenco’. © 2016 Society of Chemical Industry
Agroindustrial composts to reduce the use of peat and fungicides in the cultivation of muskmelon seedlings
Authors: Morales Ana Belen , Ros Margarita , Ayuso Luis Miguel , Bustamante Maria de los Angeles , Moral Raul , Pascual Jose Antonio 
Published: May 2016

AbstractBACKGROUNDEnvironmental concerns about peat extraction in wetland ecosystems have increased. Therefore, there is an international effort to evaluate alternative organic substrates for the partial substitution of peat. The aim of this work was to use different composts (C1–C10) obtained from the fruit and vegetable processing industry (pepper, carrot, broccoli, orange, artichoke residues, sewage sludge (citric and pepper) and vineyard pruning wastes) to produce added‐value composts as growing media with suppressive effect against Fusarium oxysporum f.sp. melonis (FOM) in muskmelon.RESULTSComposts showed values of water‐soluble carbon fractions and dehydrogenase activity that allowed them to be considered mature and stabilized. All compost treatments produced significantly (F = 7.382; P < 0.05) higher fresh shoot weight than peat, treatment T‐C2 showing the highest values. Treatments T‐C5, T‐C7 and T‐C8 showed percentages of disease incidence that were significantly (F = 16.052; P < 0.05) the lowest, relative to peat, followed by T‐C6, T‐C10, T‐C1 and T‐C9 with values below 50%.CONCLUSIONComposts produced are suitable components of mixed compost–peat growing media, providing a 50% substitution of peat. Furthermore, some of these composts also showed an added value as a suppressive organic medium against Fusarium wilt in muskmelon seedling, a fact probably related to high pH and pepper wastes and high content of pruning waste as initial raw materials. © 2016 Society of Chemical Industry