bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Genome Sequences of Lytic Bacteriophages of Xanthomonas arboricola pv. juglandis
Authors: Retamales Julio , Vasquez Ignacio , Santos Leonardo , Segovia Cristopher , Ayala Manuel , Alvarado Romina , Nuñez Pablo , Santander Javier 
Published: June 2016

ABSTRACTThree bacteriophages,f20-Xaj, f29-Xaj, andf30-Xaj, with lytic activity againstXanthomonas arboricolapv. juglandis were isolated from walnut trees (VIII Bío Bío Region, Chile). These lytic bacteriophages have double-stranded DNA (dsDNA) genomes of 43,851 bp, 41,865 bp, and 44,262 bp, respectively. These are the first described bacteriophages with lytic activity againstX. arboricolapv. juglandis that can be utilized as biocontrol agents.
Draft Genome Sequence of Bacillus subtilis ALBA01, a Strain with Antagonistic Activity against the Soilborne Fungal Pathogen of Onion
Setophoma terrestris
Authors: Albarracín Orio Andrea G. , Tobares Romina A. , Ducasse Daniel A. , Smania Andrea M. 
Published: June 2016

ABSTRACT

Bacillus subtilis
is a nonpathogenic bacterium that lives in soil and has long been used as biological control agent in agriculture. Here, we report the genome sequence of a
B. subtilis
strain isolated from rhizosphere of onion that shows strong biological activity against the soilborne fungal pathogen
Setophoma terrestris
.
Draft Genome Sequences of Mycobacterium kansasii Strains 1010001454, 1010001458, 1010001468, 1010001493, 1010001495, and 1010001469, Isolated from Environmental Sources
Authors: Strapagiel Dominik , Borówka Paulina , Marciniak Błażej , Bakuła Zofia , van Ingen Jakko , Safianowska Aleksandra , Brzostek Anna , Dziadek Jarosław , Jagielski Tomasz 
Published: June 2016

ABSTRACT

Mycobacterium kansasii
belongs to the nontuberculous mycobacteria (NTM) and causes opportunistic infections with both pulmonary and extrapulmonary manifestations. Here, we report the draft genome sequences of six environmental
M. kansasii
strains, designated 1010001495 (type I), 1010001469 (type II), 1010001468 (type III), 1010001458 (type IV), 1010001454 (type V), and 1010001493 (type V), originally isolated in five different European countries.
Draft Genome Sequences of Listeria monocytogenes Serotype 4b Strains 944 and 2993 and Serotype 1/2c Strains 198 and 2932
Authors: Casey Aidan , McAuliffe Olivia , Fox Edward M. , Leong Dara , Gahan Cormac G. M. , Jordan Kieran 
Published: June 2016

ABSTRACT

Listeria monocytogenes
is a foodborne pathogen and the causative agent of listeriosis among humans and animals. The draft genome sequences of
L. monocytogenes
serotype 4b strains 944 and 2993 and serotype 1/2c strains 198 and 2932 are reported here.
Complete Genome Sequence of Enterobacter cloacae B2-DHA, a Chromium-Resistant Bacterium
Authors: Rahman Aminur , Nahar Noor , Olsson Björn , Mandal Abul 
Published: June 2016

ABSTRACT

Previously, we reported a chromium-resistant bacterium,
Enterobacter cloacae
B2-DHA, isolated from the landfills of tannery industries in Bangladesh. Here, we investigated its genetic composition using massively parallel sequencing and comparative analysis with other known
Enterobacter
genomes. Assembly of the sequencing reads revealed a genome of ~4.21 Mb in size.
Draft Genome Sequence of a Mycobacterium africanum Clinical Isolate from Antioquia, Colombia
Authors: Hurtado U. A. , Solano J. S. , Rodriguez A. , Robledo J. , Rouzaud F. 
Published: June 2016

ABSTRACT

Mycobacterium africanum
is a member of the
Mycobacterium tuberculosis
complex. Most commonly found in West African countries, it has scarcely been described in South America. Here, we report the first genome sequence of a Colombian
M. africanum
clinical isolate. It is composed of 4,493,502 bp, with 4,069 genes.
Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK
Authors: Taylor Sylvia , Taylor Robert J , Lustig Roger L , Schuck-Paim Cynthia , Haguinet François , Webb David J , Logie John , Matias Gonçalo , Fleming Douglas M 
Published: June 2016

ObjectiveThe burden of respiratory syncytial virus (RSV) illness is not well characterised in primary care. We estimated the burden of disease attributable to RSV in children in the UK between 1995 and 2009.DesignTime-series regression modelling.SettingA multiple linear regression model based on weekly viral surveillance (RSV and influenza, Public Health England), and controlled for non-specific seasonal drivers of disease, estimated the proportion of general practitioner (GP) episodes of care (counted as first visit in a series within 28 days; Clinical Practice Research Datalink, CPRD), hospitalisations (Hospital Episode Statistics, HES) and deaths (Office of National Statistics, ONS) attributable to RSV each season.ParticipantsChildren 0–17 years registered with a GP in CPRD, or with a respiratory disease outcome in the HES or ONS databases.Primary outcome measuresRSV-attributable burden of GP episodes, hospitalisations and deaths due to respiratory disease by age. RSV-attributable burden associated with selected antibiotic prescriptions.ResultsRSV-attributable respiratory disease in the UK resulted in an estimated 450 158 GP episodes, 29 160 hospitalisations and 83 deaths per average season in children and adolescents, with the highest proportions in children <6 months of age (14 441/100 000 population, 4184/100 000 and 6/100 000, respectively). In an average season, there were an estimated 125 478 GP episodes for otitis media and 416 133 prescriptions for antibiotics attributable to RSV. More GP episodes, hospitalisations and deaths from respiratory disease were attributable to RSV than to influenza in children under 5 years.ConclusionsThe burden of RSV in children in the UK exceeds that of influenza. RSV in children and adolescents contributes substantially to GP office visits for a diverse range of illnesses, and was associated with an average 416 133 prescribed antibiotic courses per season. Effective antiviral treatments and preventive vaccines are urgently needed for the management of RSV infection in children.Trial registration numberNCT01706302.
Effect of sex and age on the association between suicidal behaviour and obesity in Korean adults: a cross-sectional nationwide study
Authors: Kim Dae-Kwon , Song Hyun Jin , Lee Eui-Kyung , Kwon Jin-Won 
Published: June 2016

ObjectivesTo examine the hypothesis that the relationship between obesity and the risk of suicidal behaviour would differ according to sex and age.SettingData from the 2007–2012 Korean National Health and Nutrition Examination Survey (KNHANES) were used.Participants36 211 adults with body mass index (BMI) data were included and the mean age was 49.6 years.Independent variableBMI.Primary and secondary outcome measuresSuicide ideation and attempts.Design and analysisA cross-sectional study was performed. Multiple logistic regressions after controlling for socioeconomic variables and concomitant diseases were applied to see the relationship between obesity level and suicidal ideation or attempt.ResultsWomen with severe obesity had the highest prevalence of suicide attempts and ideation, whereas among males, underweight men had the highest prevalence. After adjustment, obese men had a lower OR for suicide ideation (OR=0.87, 95% CI 0.76 to 1.00). Among women, the ORs of severely obese and underweight women were 1.27 (95% CI 1.06 to 1.52) and 1.24 (95% CI 1.06 to 1.45), respectively. When grouped by age category, the ORs for suicide ideation in severely obese women aged 18 to <30 years or attempts in severely obese women aged 30 to <50 years were 2.30 (95% CI 1.36 to 3.89) and 3.07 (95% CI 1.50 to 6.31), respectively. However, overweight and obese women aged more than 50 years exhibited significantly less ORs of suicide ideation, when compared with counterparts of normal weight.ConclusionsThe association between obesity and suicidal behaviour exhibited a different pattern by sex and age in South Korea. In particular, severely obese young women had a substantial risk of suicidal behaviour. Our study results highlighted the importance of obesity management in the prevention of suicide among young women, and may be helpful for the drafting of the health agenda in Asian countries with an obesity prevalence and culture similar to those in Korea.
Methamphetamine use in Central Germany: protocol for a qualitative study exploring requirements and challenges in healthcare from the professionals' perspective
Authors: Hoffmann Laura , Schumann Nadine , Fankhaenel Thomas , Thiel Carolin , Klement Andreas , Richter Matthias 
Published: June 2016

IntroductionThe synthetic drug methamphetamine with its high addiction potential is associated with substantial adverse health effects. In Germany, especially Central Germany, the increase in the consumption of methamphetamine has exceeded that of other illegal drugs. The treatment system and service providers are facing new challenges due to this rise in consumption. This qualitative study will explore the demand created by the increasing healthcare needs of methamphetamine-addicted persons in Central Germany, and the difficulty of rehabilitating addicted people.Methods and analysisThe collection of empirical data will take place in a consecutive, two-stage process. In the first part of data collection, the experiences and perspectives of 40 professionals from numerous healthcare sectors for methamphetamine-addicted persons will be explored with the help of semistructured face-to-face interviews and probed by the research team. These findings will be discussed in 2 focus groups consisting of the participants of the face-to-face interviews; these group discussions comprise the second part of the data collection process. The interviews will be audio recorded, transcribed, and then subjected to qualitative content analysis.Ethics and disseminationAll interviewees will receive comprehensive written information about the study, and sign a declaration of consent prior to the interview. The study will comply rigorously with data protection legislation. The research team has obtained the approval of the Ethical Review Committee at the Martin Luther University Halle-Wittenberg, Germany. The results of the study will be published in high-quality, peer-reviewed international journals, presented at several congresses and used to design follow-up research projects.Trial registration numberVfD_METH_MD_15_003600.
Community-based physical activity and nutrition programme for adults with metabolic syndrome in Vietnam: study protocol for a cluster-randomised controlled trial
Authors: Tran Van Dinh , Lee Andy H , Jancey Jonine , James Anthony P , Howat Peter , Thi Phuong Mai Le 
Published: June 2016

IntroductionMetabolic syndrome (MetS) is a cluster of risk factors for cardiovascular diseases and type II diabetes. In Vietnam, more than one-quarter of its population aged 50–65 have MetS. This cluster-randomised controlled trial aims to evaluate the effectiveness of interventions to increase levels of physical activity and improve dietary behaviours among Vietnamese adults aged 50–65 years with MetS.Method and analysisThis 6-month community-based intervention includes a range of strategies to improve physical activity and nutrition for adults with MetS in Hanam, a province located in northern Vietnam. 600 participants will be recruited from 6 communes with 100 participants per commune. The 6 selected communes will be randomly allocated to either an intervention group (m=3; n=300) or a control group (m=3; n=300). The intervention comprises booklets, education sessions, resistance bands and attending local walking groups that provide information and encourage participants to improve their physical activity and healthy eating behaviours during the 6-month period. The control group participants will receive standard and 1-time advice. Social cognitive theory is the theoretical concept underpinning this study. Measurements will be taken at baseline and postintervention to evaluate programme effectiveness.Ethics and disseminationThe research protocol was approved by the Curtin University Human Research Ethics Committee (approval number: HR139/2014). The results of the study will be disseminated through publications, reports and conference presentations.Trial registration numberACTRN12614000811606.
The effect of the thickness of tunneling layer on the memory properties of (Cu2O)0.5(Al2O3)0.5 high-k composite charge-trapping memory devices
Authors: Liu Jinqiu , Lu Jianxin , Yin Jiang , Xu Bo , Xia Yidong , Liu Zhiguo 
Published: June 2016

The charge-trapping memory devices namely Pt/Al2O3/(Al2O[Formula: see text](Cu2O)[Formula: see text]/SiO2/[Formula: see text]-Si with 2, 3 and 4 nm SiO2 tunneling layers were fabricated by using RF magnetron sputtering and atomic layer deposition techniques. At an applied voltage of ±11 V, the memory windows in the C–V curves of the memory devices with 2, 3 and 4 nm SiO2 tunneling layers were about 4.18, 9.91 and 11.33 V, respectively. The anomaly in memory properties among the three memory devices was ascribed to the different back tunneling probabilities of trapped electrons in the charge-trapping dielectric (Al2O[Formula: see text](Cu2O)[Formula: see text] due to the different thicknesses of SiO2 tunneling layer.
Lichen Sclerosus: Incidence and Risk of Vulvar Squamous Cell Carcinoma
Authors: Bleeker Maaike C.G. , Visser Pascal J. , Overbeek Lucy I.H. , van Beurden Marc , Berkhof Johannes 
Published: June 2016

Abstract
Background: The association between lichen sclerosus and vulvar squamous cell carcinoma (VSCC) has long been recognized, but large epidemiologic studies are lacking.
Methods: Data of women diagnosed with vulvar pathology in the Netherlands were retrieved from the Dutch Pathology Registry. All vulvar pathology reports of this historical cohort were reviewed to construct a research database, including 3,038 women with lichen sclerosus diagnosed between 1991 and 2011. The incidence rate of lichen sclerosus and the cumulative incidence of VSCC among women with lichen sclerosus were estimated.
Results: Between 1991 and 2011, the incidence rate of lichen sclerosus increased from 7.4 to 14.6 per 100,000 woman-years. The median age at time of lichen sclerosus diagnosis was 59.8 years and the cumulative VSCC incidence was 6.7%. The 10-year VSCC incidence in women with lichen sclerosus was associated with concurrent vulvar intraepithelial neoplasia (VIN; 18.8% in women with VIN and 2.8% in women without VIN) and age at time of lichen sclerosus diagnosis (5.9% in women of ≥70 years, 3% in women between 50 and 70 years, and 1.8% in women &lt;50 years). The effects of presence of VIN and age remained significant in adjusted Cox regression analysis.
Conclusion: This historical cohort showed a nearly 100% increase in incidence of lichen sclerosus between 1991 and 2011. Concurrent VIN and age ≥70 years at time of lichen sclerosus diagnosis are important risk factors for vulvar cancer development.
Impact: The incidence of lichen sclerosus is rising and special attention is needed in particular in women with concurrent VIN because of their high risk of cancer. Cancer Epidemiol Biomarkers Prev; 25(8); 1224–30. ©2016 AACR.
In Silico Analysis Guides Selection of BET Inhibitors for Triple-Negative Breast Cancer Treatment
Authors: Pérez-Peña Javier , Serrano-Heras Gemma , Montero Juan Carlos , Corrales-Sánchez Verónica , Pandiella Atanasio , Ocaña Alberto 
Published: June 2016

Abstract
Triple-negative breast cancer (TNBC) is an incurable disease with poor prognosis. At this moment, therapeutic options are limited to chemotherapy, and no targeted agent has reached the clinical setting. Bromodomain and extraterminal (BET) inhibitors are a new family of compounds that inhibit bromodomain-containing proteins affecting the expression of transcription factors, therefore modifying the expression of relevant oncogenic genes. In the present article, by using an in silico approach, we have identified the expression of upregulated transcription factors in TNBC compared with normal breast. Treatment with JQ1, a well-characterized BET inhibitor, modified some transcription factors, including DEP domain containing 1 (DEPDC), Forkhead box M1 (FOXM1), and Lim domain only 4 (LM04). In cell line models, administration of JQ1 or OTX015, another BET inhibitor, produced a significant antiproliferative effect and synergized with chemotherapies. Biochemical evaluation demonstrated an arrest at G1 as the main mechanism of action with a clear increase of p27. Addition of these compounds to chemotherapy induced apoptosis compared to each agent given alone. Evaluation of JQ1 in xenografted tumors in nude mice showed a profound antitumoral effect with a reduction of DEPDC, FOXM1, and LM04, in addition to an increase of p27. Globally, our data demonstrate the antitumor effect of this new family of compounds in TNBC, paving the way for its future clinical development. Mol Cancer Ther; 15(8); 1823–33. ©2016 AACR.
Senescence Can Be BETter without the SASP?
Authors: Vizioli Maria Grazia , Adams Peter D. 
Published: June 2016

Abstract
Summary: Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo. Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.Cancer Discov; 6(6); 576–8. ©2016 AACR.
See related article by Tasdemir et al., p. 612.
The Hannover Patient University: Advanced Mini-Med School concept and evaluation results
Authors: Seidel Gabriele , Kaiser Birgit , Lander Jonas , Dierks Marie-Luise 
Published: June 2016

Objective: To determine whether Hannover Medical School’s Patient University, which was developed as the first university-based health education institution in Germany, offers a valuable means of conveying health-related knowledge, competencies and the ability to reflect on health information to its participants. Design: Participatory health education formats included interactive lectures, learning stations and practical training with tutors. Setting: The Patient University was conducted at the facilities of Hannover Medical School, a major German maximum-care hospital and research institution. Methods: To evaluate the programme, data were prospectively collected from participants from 2007 to 2009 using standardised and anonymous questionnaires. One questionnaire included information on sociodemographic data, such as health status, age, gender and post code. A second questionnaire evaluated levels of participant satisfaction, new knowledge and skills gained and understanding of the information provided. Results: Approximately 1,935 participants enrolled in at least one of 60 events from 2007 to 2009. The response rate from the questionnaire collecting sociodemographic data was 61.4%. A total of 35.2% of participants responded to the event evaluation. After matching both questionnaires, 1,188 person-specific data sets were available for analysis. Most respondents were women (74.7%), and the median age was 62 years (range: 16–88 years). Satisfaction with the events was rated very positive (average 1.7 on a scale of 1 =  excellent to 6 =  poor). Nearly two-thirds of the participants acquired new health-related knowledge and were highly satisfied with the quality of the information received. Participants who self-rated their health status as ‘poor’ tended to be more critical of what they had received than those in good health. Conclusion: We consider the approach a viable health education advance, and future Mini-Med School programmes may benefit from its methodological and evaluative insights. The development of target group-specific information should be the focus of prospective initiatives and related research.
A novel approach for developing high thermal conductive artificial leather by utilizing smart electronic materials
Authors: Yang Chenxiao , Wang Jingping , Li Li 
Published: June 2016

Nowadays, artificial leather is an important commodity in daily life, especially in the fields of apparels, stationery and furniture. However, due to the maturity of producing technology and market segmentation, the industry trends to be saturated. Leather product manufacturers face intense competition and increasing production costs to survive on feeble profits. Thus, everyone is seeking a solution to break this predicament. Thanks to technical advancement and diversified intelligent electronics, a promising market opportunity has emerged that looks for innovative functional leather. This leather can exhibit high thermal conductivity and act as an essential component of electronic outside packages to prevent over-heating. This study aims to develop a high thermal conductive artificial leather (HTCAL). It incorporates smart electronic textile material (conductive yarn) into traditional artificial leather production through modifying the material and structure of its base layer. The result showed that the thermal conductivity of HTCAL was improved by 19.6% and, when wearing directly, a significant temperature gap between skin and the inner side of the leather occurred, which could offer a comfort cool feeling when worn in summer. This approach is a breakthrough to seize a new opportunity and offer an advancing direction. Further, this HTCAL can free the industry from periodical demand restriction, that is, seasonal limitation, and broaden product research and development into more fields. Thus, this approach can not only improve manufacturers' competitiveness and break them out of the current predicament, but also it creates new business opportunities.
The World Anti-Doping Code: can you have asthma and still be an elite athlete?
Authors: Fitch Ken 
Published: June 2016

Key pointsThe World Anti-Doping Code (the Code) does place some restrictions on prescribing inhaled β2-agonists, but these can be overcome without jeopardising the treatment of elite athletes with asthma.While the Code permits the use of inhaled glucocorticoids without restriction, oral and intravenous glucocorticoids are prohibited, although a mechanism exists that allows them to be administered for acute severe asthma.Although asthmatic athletes achieved outstanding sporting success during the 1950s and 1960s before any anti-doping rules existed, since introduction of the Code’s policies on some drugs to manage asthma results at the Olympic Games have revealed that athletes with confirmed asthma/airway hyperresponsiveness (AHR) have outperformed their non-asthmatic rivals.It appears that years of intensive endurance training can provoke airway injury, AHR and asthma in athletes without any past history of asthma. Although further research is needed, it appears that these consequences of airway injury may abate in some athletes after they have ceased intensive training.The World Anti-Doping Code (the Code) has not prevented asthmatic individuals from becoming elite athletes. This review examines those sections of the Code that are relevant to respiratory physicians who manage elite and sub-elite athletes with asthma. The restrictions that the Code places or may place on the prescription of drugs to prevent and treat asthma in athletes are discussed. In addition, the means by which respiratory physicians are able to treat their elite asthmatic athlete patients with drugs that are prohibited in sport are outlined, along with some of the pitfalls in such management and how best to prevent or minimise them.