bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully inkjet-printed two-dimensional material field-effect heterojunctions for wearable and textile electronics
Authors: Carey Tian , Cacovich Stefania , Divitini Giorgio , Ren Jiesheng , Mansouri Aida , Kim Jong M. , Wang Chaoxia , Ducati Caterina , Sordan Roman , Torrisi Felice 
Published: October 2017

AbstractFully printed wearable electronics based on two-dimensional (2D) material heterojunction structures also known as heterostructures, such as field-effect transistors, require robust and reproducible printed multi-layer stacks consisting of active channel, dielectric and conductive contact layers. Solution processing of graphite and other layered materials provides low-cost inks enabling printed electronic devices, for example by inkjet printing. However, the limited quality of the 2D-material inks, the complexity of the layered arrangement, and the lack of a dielectric 2D-material ink able to operate at room temperature, under strain and after several washing cycles has impeded the fabrication of electronic devices on textile with fully printed 2D heterostructures. Here we demonstrate fully inkjet-printed 2D-material active heterostructures with graphene and hexagonal-boron nitride (h-BN) inks, and use them to fabricate all inkjet-printed flexible and washable field-effect transistors on textile, reaching a field-effect mobility of ~91 cm2 V−1 s−1, at low voltage (<5 V). This enables fully inkjet-printed electronic circuits, such as reprogrammable volatile memory cells, complementary inverters and OR logic gates.
Integrated Pound−Drever−Hall laser stabilization system in silicon
Authors: Idjadi Mohamad Hossein , Aflatouni Firooz 
Published: October 2017

AbstractLow noise stable lasers have far-reaching applications in spectroscopy, communication, metrology and basic science. The Pound−Drever−Hall laser stabilization technique is widely used to stabilize different types of lasers in these areas. Here we report the demonstration of an integrated Pound−Drever−Hall system that can stabilize a low-cost laser to realize a compact inexpensive light source, which can ultimately impact many fields of science and engineering. We present an integrated architecture utilizing an electronically reconfigurable Mach−Zehnder interferometer as the frequency reference to reduce the frequency noise of semiconductor lasers by more than 25 dB and the relative Allan deviation by more than 12 times at 200 μs averaging time. Compared to the bench-top implementations, the integrated Pound−Drever−Hall system has significantly lower power consumption, less sensitivity to the environmental fluctuations and occupies an area of only 2.38 mm2. The photonic and electronic devices are integrated on a standard 180 nm complementary metal-oxide semiconductor silicon-on-insulator process.
Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s
Authors: Yang Jiao , Zong Yinong , Su Jiayue , Li Hongtao , Zhu Huanyu , Columbus Linda , Zhou Lei , Liu Qinglian 
Published: October 2017

AbstractCellular protein homeostasis depends on heat shock proteins 70 kDa (Hsp70s), a class of ubiquitous and highly conserved molecular chaperone. Key to the chaperone activity is an ATP-induced allosteric regulation of polypeptide substrate binding and release. To illuminate the molecular mechanism of this allosteric coupling, here we present a novel crystal structure of an intact human BiP, an essential Hsp70 in ER, in an ATP-bound state. Strikingly, the polypeptide-binding pocket is completely closed, seemingly excluding any substrate binding. Our FRET, biochemical and EPR analysis suggests that this fully closed conformation is the major conformation for the ATP-bound state in solution, providing evidence for an active release of bound polypeptide substrates following ATP binding. The Hsp40 co-chaperone converts this fully closed conformation to an open conformation to initiate productive substrate binding. Taken together, this study provided a mechanistic understanding of the dynamic nature of the polypeptide-binding pocket in the Hsp70 chaperone cycle.
Structural determinants and functional consequences of protein affinity for membrane rafts
Authors: Lorent Joseph H. , Diaz-Rohrer Blanca , Lin Xubo , Spring Kevin , Gorfe Alemayehu A. , Levental Kandice R. , Levental Ilya 
Published: October 2017

AbstractEukaryotic plasma membranes are compartmentalized into functional lateral domains, including lipid-driven membrane rafts. Rafts are involved in most plasma membrane functions by selective recruitment and retention of specific proteins. However, the structural determinants of transmembrane protein partitioning to raft domains are not fully understood. Hypothesizing that protein transmembrane domains (TMDs) determine raft association, here we directly quantify raft affinity for dozens of TMDs. We identify three physical features that independently affect raft partitioning, namely TMD surface area, length, and palmitoylation. We rationalize these findings into a mechanistic, physical model that predicts raft affinity from the protein sequence. Application of these concepts to the human proteome reveals that plasma membrane proteins have higher raft affinity than those of intracellular membranes, consistent with raft-mediated plasma membrane sorting. Overall, our experimental observations and physical model establish general rules for raft partitioning of TMDs and support the central role of rafts in membrane traffic.
Functional mapping of brain synapses by the enriching activity-marker SynaptoZip
Authors: Ferro Mattia , Lamanna Jacopo , Ripamonti Maddalena , Racchetti Gabriella , Arena Alessandro , Spadini Sara , Montesano Giovanni , Cortese Riccardo , Zimarino Vincenzo , Malgaroli Antonio 
Published: October 2017

AbstractIdeally, elucidating the role of specific brain circuits in animal behavior would require the ability to measure activity at all involved synapses, possibly with unrestricted field of view, thus even at those boutons deeply located into the brain. Here, we introduce and validate an efficient scheme reporting synaptic vesicle cycling in vivo. This is based on SynaptoZip, a genetically encoded molecule deploying in the vesicular lumen a bait moiety designed to capture upon exocytosis a labeled alien peptide, Synbond. The resulting signal is cumulative and stores the number of cycling events occurring at individual synapses. Since this functional signal is enduring and measurable both online and ex post, SynaptoZip provides a unique method for the analysis of the history of synaptic activity in regions several millimeters below the brain surface. We show its broad applicability by reporting stimulus-evoked and spontaneous circuit activity in wide cortical fields, in anesthetized and freely moving animals.
Anomalous elastic properties across the γ to α volume collapse in cerium
Authors: Lipp Magnus J. , Jenei Zs. , Cynn H. , Kono Y. , Park C. , Kenney-Benson C. , Evans W. J. 
Published: October 2017

AbstractThe behavior of the f-electrons in the lanthanides and actinides governs important macroscopic properties but their pressure and temperature dependence is not fully explored. Cerium with nominally just one 4f electron offers a case study with its iso-structural volume collapse from the γ-phase to the α-phase ending in a critical point (pC, VC, TC), unique among the elements, whose mechanism remains controversial. Here, we present longitudinal (cL) and transverse sound speeds (cT) versus pressure from higher than room temperature to TC for the first time. While cL experiences a non-linear dip at the volume collapse, cT shows a step-like change. This produces very peculiar macroscopic properties: the minimum in the bulk modulus becomes more pronounced, the step-like increase of the shear modulus diminishes and the Poisson’s ratio becomes negative—meaning that cerium becomes auxetic. At the critical point itself cerium lacks any compressive strength but offers resistance to shear.
Distributed optical fibre sensing for early detection of shallow landslides triggering
Authors: Schenato Luca , Palmieri Luca , Camporese Matteo , Bersan Silvia , Cola Simonetta , Pasuto Alessandro , Galtarossa Andrea , Salandin Paolo , Simonini Paolo 
Published: October 2017

ABSTRACTA distributed optical fibre sensing system is used to measure landslide-induced strains on an optical fibre buried in a large scale physical model of a slope. The fibre sensing cable is deployed at the predefined failure surface and interrogated by means of optical frequency domain reflectometry. The strain evolution is measured with centimetre spatial resolution until the occurrence of the slope failure. Standard legacy sensors measuring soil moisture and pore water pressure are installed at different depths and positions along the slope for comparison and validation. The evolution of the strain field is related to landslide dynamics with unprecedented resolution and insight. In fact, the results of the experiment clearly identify several phases within the evolution of the landslide and show that optical fibres can detect precursory signs of failure well before the collapse, paving the way for the development of more effective early warning systems.
Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles
Authors: Inocencio Ishmael M. , Bischof Robert J. , Xiang Sue D. , Zahra Valerie A. , Nguyen Vy , Lim Tammy , LaRosa Domenic , Barbuto Jade , Tolcos Mary , Plebanski Magdalena , Polglase Graeme R. , Moss Timothy J. 
Published: October 2017

AbstractMechanical ventilation of preterm neonates causes lung inflammation and injury, with potential life-long consequences. Inert 50-nm polystyrene nanoparticles (PS50G) reduce allergic inflammation in the lungs of adult mice. We aimed to confirm the anti-inflammatory effects of PS50G in a sheep asthma model, and investigate the effects of prophylactic administration of PS50G on ventilation-induced lung injury (VILI) in preterm lambs. We assessed lung inflammatory cell infiltration, with and without PS50G, after airway allergen challenge in ewes sensitised to house dust mite. Preterm lambs (0.83 gestation) were delivered by caesarean section for immediate tissue collection (n = 5) or ventilation either with (n = 6) or without (n = 5) prophylactic intra-tracheal administration of PS50G nanoparticles (3% in 2 ml). Ventilation was continued for a total of 2 h before tissue collection for histological and biomolecular assessment of lung injury and inflammation. In ewes with experimental asthma, PS50G decreased eosinophilic infiltration of the lungs. Ventilated preterm lambs showed molecular and histological signs of lung injury and inflammation, which were exacerbated in lambs that received PSG50G. PS50G treatment decreased established inflammation in the lungs of asthmatic sheep. However, prophylactic administration of PSG50 exacerbated ventilation-induced lung injury and lung inflammation in preterm lambs.
In vivo near-infrared imaging of ErbB2 expressing breast tumors with dual-axes confocal endomicroscopy using a targeted peptide
Authors: Gao Zhenghong , Li Gaoming , Li Xue , Zhou Juan , Duan Xiyu , Chen Jing , Joshi Bishnu P. , Kuick Rork , Khoury Basma , Thomas Dafydd G. , Fields Tina , Sabel Michael S. , Appelman Henry D. , Zhou Quan , Li Haijun , Kozloff Ken , Wang Thomas D. 
Published: October 2017

AbstractErbB2 expression in early breast cancer can predict tumor aggressiveness and clinical outcomes in large patient populations. Accurate assessment with physical biopsy and conventional pathology can be limited by tumor heterogeneity. We aim to demonstrate real-time optical sectioning using a near-infrared labeled ErbB2 peptide that generates tumor-specific contrast in human xenograft breast tumorsin vivo. We used IRDye800CW as the fluorophore, validated performance characteristics for specific peptide binding to cellsin vitro, and investigated peak peptide uptake in tumors using photoacoustic tomography. We performed real-time optical imaging using a handheld dual-axes confocal fluorescence endomicroscope that collects light off-axis to reduce tissue scattering for greater imaging depths. Optical sections in either the vertical or horizontal plane were collected with sub-cellular resolution. Also, we found significantly greater peptide binding to pre-clinical xenograft breast cancerin vivoand to human specimens of invasive ductal carcinoma that express ErbB2ex vivo. We used a scrambled peptide for control. Peptide biodistribution showed high tumor uptake by comparison with other organs to support safety. This novel integrated imaging strategy is promising for visualizing ErbB2 expression in breast tumors and serve as an adjunct during surgery to improve diagnostic accuracy, identify tumor margins, and stage early cancers.
Microbes affected the TYLCCNV transmission rate by the Q biotype whitefly under high O3
Authors: Hong Yanyun , Yi Tuyong , Tan Xiaoling , Su Jianwei , Ge Feng 
Published: October 2017

AbstractOzone (O3) is a major air pollutant that has a profound effect on whole ecosystems. In this study we studied how hO3 affected the transmission of theTomato yellow leaf curl China virus(TYLCCNV), a begomovirus, by the Q biotypeBemisia tabaciin a persistent, circulative manner. We found hO3 affected the transmission ofTYLCCNVvia the effect of it on the microbial community of the transmitting insect, such asCandidatus Hamiltonella,Ralstonia,Diaphorobacter,Caldilineaceae,Deinococcus,Rickettsia,Thysanophora penicillioidesandWallemia ichthyophaga. We concluded that hO3decreased the resistance of acquiring virus tomatoes, and decreased the immune response and increased the endurance to extreme environments of viruliferous whiteflies by altering the composition and abundance of the microbial environments inside the body and on the surface of whitefly, as a result, it enhanced the TYLCV transmission rate by the Q biotype whitefly.
Elastic evolution of a self-healing ionomer observed via acoustic and ultrasonic resonant spectroscopy
Authors: Pestka K. A. , Buckley J. D. , Kalista S. J. , Bowers N. R. 
Published: October 2017

AbstractSelf-healing poly (ethylene co-methacrylic acid) ionomers (EMAA) are thermoplastic materials that when punctured, cut, shot or damaged in a variety of ways, are capable of autonomously reorganizing their physical structure to heal and, in many instances, permanently seal the damaged location. However, a complete picture of the mechanisms responsible for their unusual behavior is not well understood. In this article we report the observation of time dependent acoustic and ultrasonic spectral evolution, measured using resonant acoustic and ultrasonic spectroscopy, for both pre and post-damage EMAA samples. The results provide a means to differentiate healing phases, quantify healing timescales, and potentially elucidate the composition parameters that most significantly impact healing behavior.
Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice
Authors: Wang Na , Tian Xiong , Chen Yu , Tan Hui-qi , Xie Pei-jian , Chen Shao-jun , Fu Yu-cai , Chen Yi-xin , Xu Wen-can , Wei Chi-ju 
Published: October 2017

AbstractThe aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal fat, Lee’s index, and liver cholesterol. Blood HDL-cholesterol increased, but total cholesterol and aspartate transaminase decreased. Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products. Islet number, β-cell percentage and mass increased, while islet size decreased. Consistently, less apoptosis but more β-cell proliferation were found in islets of treated mice. Freshly isolated islets from treated mice showed higher insulin content and enhanced glucose stimulated insulin secretion (GSIS). In addition, purified islets of Balb/c mice showed increased GSIS after cultivation in vitro with doxycycline, but not with chloramphenicol and levofloxacin. Inflammation markers, including lipopolysaccharides (LPS) and C-reactive protein (CRP) in serum as well as CD68-positive cells in treated islets, decreased significantly. Finally, LPS stimulated the production of inflammatory factors but inhibited GSIS of MIN6 cells; however, the effects were completely reversed by doxycycline. The results support further study of possible long-term usage of sub-antimicrobial doxycycline in diabetic patients.
Quantitative proteomic Analysis Reveals up-regulation of caveolin-1 in FOXP3-overexpressed human gastric cancer cells
Authors: Pan Duyi , Gao Jing , Zeng Xiaoqing , Ma Guifen , Li Na , Huang Xiaoquan , Du Xuanling , Miao Qing , Lian Jingjing , Xu Lili , Zhou Hu , Chen Shiyao 
Published: October 2017

AbstractForkhead box protein 3 (FOXP3) is implicated in tumor progression and prognosis in various types of tumor cells. We have recently reported that FOXP3 inhibited proliferation of gastric cancer (GC) cells through activating the apoptotic signaling pathway. In this study, we found that over-expression of FOXP3 inhibited GC cell migration, invasion and proliferation. Then, the label-free quantitative proteomic approach was employed to further investigating the down-stream proteins regulated by FOXP3, resulting in a total of 3,978 proteins quantified, including 186 significantly changed proteins. Caveolin-1 (CAV1), as a main constituent protein of caveolae, was one of those changed proteins up-regulated in FOXP3-overexpressed GC cells, moreover, it was assigned as one of the node proteins in the protein-protein interaction network and the key protein involved in focal adhesion pathway by bioinformatics analysis. Further biological experiments confirmed that FOXP3 directly bound to the promoter regions of CAV1 to positively regulate CAV1 transcription in GC cells. In summary, our study suggested that FOXP3 can be considered as a tumor suppressor in GC via positively regulating CAV1 through transcriptional activation, and this FOXP3-CAV1 transcriptional regulation axis may play an important role in inhibiting invasion and metastasis of GC cells. Data are available via ProteomeXchange under identifier PXD007725.
Reversible tuning of magnetocaloric Ni-Mn-Ga-Co films on ferroelectric PMN-PT substrates
Authors: Schleicher Benjamin , Niemann Robert , Schwabe Stefan , Hühne Ruben , Schultz Ludwig , Nielsch Kornelius , Fähler Sebastian 
Published: October 2017

AbstractTuning functional properties of thin caloric films by mechanical stress is currently of high interest. In particular, a controllable magnetisation or transition temperature is desired for improved usability in magnetocaloric devices. Here, we present results of epitaxial magnetocaloric Ni-Mn-Ga-Co thin films on ferroelectric Pb(Mg1/3Nb2/3)0.72Ti0.28O3 (PMN-PT) substrates. Utilizing X-ray diffraction measurements, we demonstrate that the strain induced in the substrate by application of an electric field can be transferred to the thin film, resulting in a change of the lattice parameters. We examined the consequences of this strain on the magnetic properties of the thin film by temperature- and electric field-dependent measurements. We did not observe a change of martensitic transformation temperature but a reversible change of magnetisation within the austenitic state, which we attribute to the intrinsic magnetic instability of this metamagnetic Heusler alloy. We demonstrate an electric field-controlled entropy change of about 31 % of the magnetocaloric effect - without any hysteresis.
Postural Screening for Adolescent Idiopathic Scoliosis with Infrared Thermography
Authors: Kwok Garcia , Yip Joanne , Yick Kit-Lun , Cheung Mei-Chun , Tse Chi-Yung , Ng Sun-Pui , Luximon Ameersing 
Published: October 2017

AbstractAdolescent idiopathic scoliosis (AIS) is a multifactorial, three-dimensional deformity of the spine and trunk. School scoliosis screening (SSS) is recommended by researchers as a means of early detection of AIS to prevent its progression in school-aged children. The traditional screening technique for AIS is the forward bending test because it is simple, non-invasive and inexpensive. Other tests, such as the use of Moiré topography, have reduced the high false referral rates. The use of infrared (IR) thermography for screening purposes based on the findings of previous studies on the asymmetrical paraspinal muscle activity of scoliotic patients compared with non-scoliotic subjects was explored in this study. IR thermography is performed with an IR camera to determine the temperature differences in paraspinal muscle activity. A statistical analysis showed that scoliotic subjects demonstrate a statistically significant difference between the left and right sides of the regions of interest. This difference could be due to the higher IR emission of the convex side of the observed area, thereby creating a higher temperature distribution. The findings of this study suggest the feasibility of incorporating IR thermography as part of SSS. However, future studies could also consider a larger sample of both non-scoliotic and scoliotic subjects to further validate the findings.
Innervation of the lophophore suggests that the phoronid Phoronis ovalis is a link between phoronids and bryozoans
Authors: Temereva Elena N. 
Published: October 2017

AbstractThe validity of the Lophophorata as a monophyletic group remains controversial. New data on the innervation of the lophophore, which is a unique feature of the lophophorates, may help clarify the status of the Lophophorata and provide new information on the early evolution of the group. In this paper, the organization of the nervous system of the lophophore is described in adults of the minute phoronid Phoronis ovalis. The lophophore nervous system includes a dorsal ganglion, a tentacular nerve ring, an inner ganglion, an inner nerve ring, and six nerves in each tentacle. The inner ganglion and inner nerve ring, which is associated with sensory cells, are described for the first time in adult phoronids. The general plan of the nervous system of the lophophore and tentacles is similar in P. ovalis and bryozoans. These new results suggest the presence of two nerve centers and two nerve rings in the last common ancestor of phoronids and bryozoans. During evolution, bryozoans may have lost the outer nerve center and outer nerve ring, whereas phoronids may have lost the inner nerve center and inner nerve ring. These morphological results evidence the lophophorates are monophyletic.