bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Skeletal Muscle Pathology in Patients With Heart Failure and Reduced Ejection Fraction
Authors: Wood Nathanael , Critchlow Annabel , Cheng Chew W. , Straw Sam , Hendrickse Paul W. , Pereira Marcelo G. , Wheatcroft Stephen B. , Egginton Stuart , Witte Klaus K. , Roberts Lee D. , Bowen T. Scott 
Published: October 2024

BACKGROUND:
Women with heart failure and reduced ejection fraction (HFrEF) have greater symptoms and a lower quality of life compared with men; however, the role of noncardiac mechanisms remains poorly resolved. We hypothesized that differences in skeletal muscle pathology between men and women with HFrEF may explain clinical heterogeneity.

METHODS:
Muscle biopsies from both men (n=22) and women (n=16) with moderate HFrEF (New York Heart Association classes I–III) and age- and sex-matched controls (n=18 and n=16, respectively) underwent transcriptomics (RNA-sequencing), myofiber structural imaging (histology), and molecular signaling analysis (gene/protein expression), with serum inflammatory profiles analyzed (enzyme-linked immunosorbent assay). Two-way ANOVA was conducted (interaction sex and condition).

RESULTS:

RNA-sequencing identified 5629 differentially expressed genes between men and women with HFrEF, with upregulated terms for catabolism and downregulated terms for mitochondria in men. mRNA expression confirmed an effect of sex (
P
<0.05) on proatrophic genes related to ubiquitin proteasome, autophagy, and myostatin systems (higher in all men versus all women), whereas proanabolic
IGF1
expression was higher (
P
<0.05) in women with HFrEF only. Structurally, women compared with men with HFrEF showed a pro-oxidative phenotype, with smaller but higher numbers of type I fibers, alongside higher muscle capillarity (
P
interaction
<0.05) and higher type I fiber areal density (
P
interaction
<0.05). Differences in gene/protein expression of regulators of muscle phenotype were detected between sexes, including
HIF1α
,
ESR1
,
VEGF
(vascular endothelial growth factor), and PGC1α expression (
P
<0.05), and for upstream circulating factors, including VEGF, IL (interleukin)-6, and IL-8 (
P
<0.05).

CONCLUSIONS:
Sex differences in muscle pathology in HFrEF exist, with men showing greater abnormalities compared with women related to the transcriptome, fiber phenotype, capillarity, and circulating factors. These preliminary data question whether muscle pathology is a primary mechanism contributing to greater symptoms in women with HFrEF and highlight the need for further investigation.
Evidence of the Double Amplification of Traveling Planetary Waves during the January 2021 Sudden Stratospheric Warming
Authors: Rhodes C. Todd , Barton Cory , Eckermann Stephen , Kuhl David , Ma Jun 
Published: October 2024

Abstract
The in situ generation and characteristics of planetary waves (PWs) in the mesosphere and lower thermosphere (MLT) during the January 2021 sudden stratospheric warming (SSW) are investigated using the Navy Global Environmental Model. During SSW, upward-propagating PWs can be absorbed, refracted, or amplified, the latter implying in situ PW generation. Additionally, asymmetric dissipation of gravity wave (GW) drag in the MLT due to varying stratospheric winds may also seed PW generation. Ultimately, the interaction of waves with instability can enhance three components of PWs [westward-propagating PWs (WPWs), quasi-stationary PWs (QSPWs), and eastward-propagating PWs (EPWs)]. The propagation pathway of a wave is diagnosed by its refractive index and is dependent on factors such as the baroclinic/barotropic stability of the atmosphere, the wave’s relative phase velocity, and the wavenumber. Through these pathways, waves are able to transfer heat and momentum throughout the atmosphere. Under particular conditions, the waves can amplify in situ by extracting energy from the background wind. Our study identifies two scenarios in which WPWs and EPWs were amplified successively. Amplified WPWs propagated upward and influenced the MLT, while amplified EPWs propagated downward and influenced the upper troposphere.
Risk Factors for High Repair Tension During Rotator Cuff Repair
Authors: Miyake Satoshi , Shibata Terufumi , Kobayashi Shunsuke , Matsunaga Kei , Hata Naofumi , Shibata Yozo , Izaki Teruaki , Yamamoto Takuaki 
Published: October 2024

Background: Excessively high repair tension, especially tension ≥10 N, can lead to unsuccessful rotator cuff repair. Purpose/Hypothesis: The purpose of this study was to identify the preoperative risk factors for high repair tension in rotator cuff repair. It was hypothesized was that older age, longer symptom duration, nontraumatic (ie, degenerative) tear onset, progressive fatty degeneration, and larger tear size would be among the risk factors. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This retrospective study involved 80 patients (80 shoulders) diagnosed with rotator cuff tears by magnetic resonance imaging between July 2018 and August 2020. Repair tension was measured intraoperatively using a digital tension meter. Risk factors for high repair tension (≥10 N) were evaluated. The t test was used to assess the relationship of repair tension with patient characteristics and surgical parameters. Parameters with a P value of <.05 in the univariate analysis were entered into a multivariate logistic regression model to determine their relationship with repair tension ≥10 N. Results: Symptom duration of ≥4 months, nontraumatic tear onset, large/massive tears, mediolateral (ML) tear length of ≥20 mm, and anteroposterior (AP) tear length of ≥18 mm were associated with high odds of repair tension ≥10 N ( P≤ .013 for all). Multivariate analysis showed that nontraumatic onset, ML tear length of ≥20 mm, and AP tear length of ≥18 mm were independent risk factors for repair tension ≥10 N ( P≤ .035 for all). Conclusion: The independent risk factors for high repair tension (≥10 N) during rotator cuff repair were nontraumatic tear onset, ML tear length of ≥20 mm, and AP tear length of ≥18 mm. Symptom duration of ≥4 months and large/massive tears were associated with high odds of repair tension ≥10 N, although they were not considered independent risk factors. Prospective cohort studies with larger sample sizes are needed to confirm the clinical value of the risk factors identified in this study.
Surgical Treatment of Insertional Achilles Tendinopathy Augmented With Human Acellular Dermal Matrix: A Retrospective Case Series
Authors: Corlee Bryce , Bloomquist Mitchell , Brantley Branden , Hamilton Curtis , Ringus Vytautas 
Published: October 2024

Background: Insertional Achilles tendinopathy (IAT) is often surgically treated with Achilles tendon partial or total detachment, debridement and repair of the Achilles tendon, excision of retrocalcaneal exostosis, and suture anchor reattachment. To date, there is no report that examines the use of acellular dermal matrix (ADM) augmentation in this procedure without the use of suture anchor reattachment. Methods: Thirty-two female and 10 male patients (mean age 52 years) with IAT underwent surgical treatment including partial detachment of the Achilles tendon, excision of the retrocalcaneal exostosis, debridement and repair of the Achilles tendon, and augmentation with human acellular dermal matrix allograft. Outcomes measured were the visual analog scale (VAS) score, time to weightbearing, major and minor complications. Results: Forty-two patients were followed for a mean of 20.8 months. The VAS score improved from a mean of 5.1 to 1.9 at final follow-up. The mean time to weightbearing was 4.4 weeks. Eleven patients (26.2%) experienced complications. One patient (2.4%) suffered a rupture of the Achilles in the early postoperative period. Three patients (7.1%) had delayed wound healing, with 1 (2.4%) requiring surgical debridement. Two (4.8%) experienced continued pain requiring further surgical treatment. Conclusion: This protocol for surgical treatment of IAT with the use of human ADM allograft augmentation resulted in improved VAS scores and was associated with a low risk of postoperative infection without a prolonged nonweightbearing period. Level of Evidence: Level IV, retrospective case series.
Association of dietary inflammatory index and dietary oxidative balance score with gastrointestinal cancers in NHANES 2005–2018
Authors: Chang Yu , Yu Chanjiao , Dai Xianyu , Sun Haibo , Tang Tongyu 
Published: October 2024

Abstract
Background&Aims
Gastrointestinal (GI) cancers, including gastric, liver, esophageal, pancreatic, and colorectal cancers, represent significant global health burdens. Emerging evidence suggests that dietary patterns, particularly their inflammatory and oxidative properties, may influence cancer risk. The Dietary Inflammatory Index (DII) and Dietary Oxidative Balance Score (DOBS) assess the inflammatory and oxidative effects of diets, respectively. This study aims to explore the association between DII, DOBS, and the combined risk of GI cancers, and investigates the potential mediating roles of serum albumin and red cell distribution width (RDW).

Methods
Data from 26,320 participants in the NHANES 2005–2018 cycles were analyzed. DII was calculated based on 28 dietary components, and DOBS included 17 nutrients (3 pro-oxidants and 14 antioxidants). Logistic regression models assessed the associations between DII, DOBS, and GI cancers. Restricted cubic spline (RCS) models examined dose-response relationships. Mediation analysis evaluated the roles of serum albumin and RDW. Subgroup analyses explored interactions with demographic and health-related factors.

Results
Higher DII was associated with increased GI cancer risk (OR: 1.26, 95% CI: 1.07–1.49 per unit increase), while higher DOBS was associated with reduced risk (OR: 0.90, 95% CI: 0.76–0.99 per unit increase). RCS analysis indicated a significant nonlinear relationship between DII and GI cancer risk. Serum albumin and RDW partially mediated the associations between DII, DOBS, and GI cancers. Subgroup analyses showed stronger associations for DII among certain demographics, and significant interactions were found between DII and BMI. For DOBS, significant interactions were observed with age and BMI.

Conclusion
This study reveals significant associations between dietary inflammatory and oxidative balance scores and GI cancer risk. Higher DII is linked to increased risk, while higher DOBS is protective. The mediating roles of serum albumin and RDW provide insights into underlying mechanisms. These findings underscore the potential of dietary modifications in GI cancer prevention and management, emphasizing the importance of anti-inflammatory and antioxidant-rich diets.
Tezepelumab for severe asthma: elevating current practice to recognize epithelial driven profiles
Authors: Caminati Marco , Vatrella A. , Rogliani P. , Carpagnano E. , Spanevello A. , Senna G. 
Published: October 2024

Abstract
Background
An increasing amount of evidence supports the relevance of epithelium across the wide spectrum of asthma pathobiology. On a clinical ground tezepelumab, selectively binding TSLP, a major epithelial cytokine, has demonstrated to be effective in asthma patients regardless their specific phenotype. In order to avoid the risk of considering tezepelumab as a not-specific option, the present perspective aims to sketch the tezepelumab best eligible patient profile and to propose some hallmarks of epithelial-driven disease by reviewing the published evidence on the drug mechanism of action and efficacy data.

Main body
Although it cannot rely on standardised or exclusive “markers”, the relationship between environment and poor asthma control might suggest a major relevance of the epithelial barrier dysfunction. In that light, allergy and asthma exacerbations concomitant with specific exposures (pathogens, pollutants, chemicals), as well as increased susceptibility to infections can be considered as the hallmark of an impaired epithelial immune response. Tezepelumab is effective in allergic patients, being able to reduce asthma exacerbations precipitated by the exposure to seasonal or perennial aeroallergens, including fungi. In addition, tezepelumab reduced the incidence of co-occurring respiratory illness and asthma exacerbations. In terms of inflammation, epithelial immune response has been related to an impaired mucus hypersecretion and plugging. A placebo-controlled trial demonstrated a significant reduction of mucus plugging in treated patient. Airways hyperreactivity (AHR), airways obstruction and remodelling have been described as an expression of epithelial orchestrated immunological activation. Of note, a significantly higher incidence of mannitol negative test in patients treated with tezepelumab when compared to placebo group has been observed. In addition, A 130 mL improvement in pre-BD FEV1 has been described in patients assuming Tezepelumab. The above-mentioned data suggest that bronchial reversibility and AHR can be considered “functional biomarkers” supporting patients’ phenotyping and the identification of tezepelumab best responders.

Conclusion
Integrating “functional biomarkers” to the inflammatory ones and a better characterization of asthma exacerbations might pave the way to a different and more transversal phenotyping, which overcomes the “restrictive” labels including T2 high, allergic/atopic or T2 low asthma. Precisely defining the disease characteristics and potential targets for a better control even in tezepelumab eligible subjects is essential to avoid the block buster temptation and optimize the personalized medicine approach according to each patient’s individuality.
24-hour Movement Questionnaire (QMov24h) for adults: development process and measurement properties
Authors: Rodrigues Bruno , Júdice Pedro B. , Marques Adilson , Carraça Eliana V. , Lopes Luís , Sousa-Sá Eduarda , Encantado Jorge , Videira-Silva António , Cliff Dylan P. , Mendes Romeu , Santos Rute ,   on behalf of the QMov24h working group, Silva Analiza M. , Palmeira António L. , Machado-Rodrigues Aristides M. , Sampaio Arnaldina , Moreira Carla , Agostinis-Sobrinho César , Lima Diogo , Biscoito Filipe , Rocha João , Martins Raul , Abreu Sandra , Vale Susana , Figueiras Teresa , Pereira Teresa , Simões Vera 
Published: October 2024

Abstract
Background
Sleep, sedentary behaviour, and physical activity are essential components within the 24-hour time frame. Existing questionnaires used to measure these behaviours have insufficient measurement properties and are unsuitable for assessing compliance with the WHO Physical Activity and 24-hour Movement Guidelines. To describe the development process of the 24-hour Movement Questionnaire (QMov24h) and its testing. The QMov24h was developed to gather detailed information on sleep, sedentary behaviour, and physical activity.

Methods
The sample comprised 117 participants (58% women), aged 30.95 ± 13.56 years. The development process of the QMov24h followed the COSMIN guidelines: (i) Construction of items; (ii) Face validity with end-users; (iii) Content validity with experts; (iv) Criterion validity against accelerometry and convergent validity against diary assessments; and (v) 7-day test-retest reliability.

Results
The QMov24h presented adequate content and face validity. The QMov24h showed moderate criterion validity for sleep (rho=0.343;p<0.001), light physical activity (rho=0.31;p=0.002) and total aerobic physical activity (rho=0.343;p<0.001), as well as strong criterion validity for sedentary behaviour (rho=0.428;p<0.001) and aerobic moderate-to-vigorous physical activity (rho=0.534;p<0.001). Reliability varied from poor to excellent (ICC from 0.38 to 0.962;p<0.001) for all questionnaire variables. Regarding compliance of the 24-hour movement guidelines, the questionnaire also showed a strong to almost perfect percentage of agreement with accelerometry (from 69% to 94.3%), and minimal to strong reliability (k from 0.38 to 0.87) between the first and second administrations of the QMov24h.

Conclusions
The QMov24h questionnaire is a valid and reliable tool for assessing levels of movement behaviours and compliance with guidelines in adults. Its measurement properties are comparable to, or even better than, those of existing questionnaires, while posing a similar burden to participants. The QMov24h is useful for research, clinical practice, and public health surveillance. The QMov24h has strong psychometric properties, making it suitable for translation, cultural adaptation, and testing in diverse populations for broader international use.
Pottery evolution pattern discovery based on deep learning: case study of Miaozigou culture in China
Authors: Pang Honglin , Qi Xiujin , Xiao Chengjun , Xu Ziying , Ding Guangchen , Chang Yi , Yang Xi , Duan Tianjing 
Published: October 2024

Abstract
Potteries, one of the tools widely used by early humans, encapsulates rich historical information. Deep neural networks have been applied to analyzing pottery digital images, bypassing the need for intricate handcrafted features. However, existing models focus solely on pottery shape comparison, neglecting the analysis of their evolution across different historical periods. In this work, we propose a method based on deep learning to assist experts in identifying the evolutionary patterns of a given pottery type within their specified chronological divisions. First we train a convolutional neural network for pottery classification, extracting low and high level features that represent different ages of pottery samples. Next, we employ clustering algorithms to identify representative potteries for each historical period based on high level features. To facilitate intuitive comparisons across different ages, we use shallow features and compute cosine similarities between potteries, visualizing shape and decoration differences. This approach enhances understanding of pottery evolution patterns directly through visual analysis. The effectiveness and efficiency of our proposed method are evaluated by validating it on three distinct era division cases using data from the Dabagou and Miaozigou archaeological sites, which represent the Miaozigou culture and exhibit clear evolutionary patterns. Our method identifies representative artifacts for each era and uncovers their evolutionary patterns effectively and efficiently, achieving conclusions comparable to those of experts while significantly reducing time compared to traditional manual methods.
Management of gastroschisis in an extremely low birth weight infant: report of a case
Authors: Oyachi Noboru , Numano Fuminori , Shinohara Tamao , Murakami Yasushi , Nemoto Atsushi , Naito Atsushi 
Published: October 2024

Abstract
Background
Gastroschisis is a rare congenital anomaly in which abdominal organs herniate through a defect in the abdominal wall. Managing gastroschisis in extremely low birth weight (ELBW) infants presents significant challenges because of their immature physiologies and increased risk of complications.
Case presentation: This report discusses the case of a female ELBW infant born via an emergency cesarean section at 29 weeks of gestation, weighing 768 g, who had a prenatal diagnosis of gastroschisis. Postnatal management included immediate surgical intervention using a hand-made silo manufactured from expanded polytetrafluoroethylene (ePTFE) sheets that were sutured to the patient’s abdominal wall to accommodate her small abdominal cavity and preserve mesenteric blood flow. Necrotizing enterocolitis with bowel perforation emerged as a complication, which led to the excision of a 10 cm segment of the ileum and the creation of an ileostomy. The infant experienced insufficient weight gain and liver dysfunction. However, she was eventually discharged on day 142 of life, weighing 2774 g, on oral feeding, without significant complications.

Conclusions
This case emphasizes how prematurity significantly affected the patient’s clinical outcomes, and highlights the importance of individualized management strategies. Our experience demonstrates that custom silo placement allows for the size to be adapted to the abdominal defect, and highlights the critical need to prioritize postnatal bowel perfusion in ELBW infants with gastroschisis.
Disabling foot pain and its impact on daily living among people with psoriatic arthritis in Singapore: a cross-sectional observational investigation
Authors: Teo Vanessa H. Y. , Chia Kai Li , Bowen Catherine , Lahiri Manjari , Cheung Peter P. M. , Turner Deborah E. , Carter Kate 
Published: October 2024

Abstract
Background
Psoriatic Arthritis (PsA)-related foot involvement has been shown to have a profound impact on daily functioning, with most studies having focused on predominantly Caucasian populations. The aim was to describe disabling foot pain (DFP) and its impact on daily living in PsA in Singapore.

Methods
A cross-sectional, retrospective study was conducted using clinical data collected during a single-visit to a rheumatology clinic in Singapore. Records for adults with physician-diagnosed PsA were reviewed for sociodemographic information, disease characteristics, global disease activity and burden. Foot-specific measures included clinical assessment and the Manchester Foot Pain and Disability Index used to define DFP and evaluate between-group differences.

Results
Forty-two participants with PsA (83% female, 57% Chinese, 31% Malay, 9.5% Indian, mean (SD) age 54-years (16)) attended the rheumatology clinic over the study-period. The median (IQR) disease duration was 2-years (11) and all were taking current DMARDs. Global disease measures demonstrated mild-to-moderate global disease activity and mild functional impairment, and were significantly higher in those with DFP. Despite 90% reporting to be coping well with their condition, self-care and having emotional support (n = 38), this study sample demonstrated high levels of anxiety/depression (29%), sleep disturbance (34%) and fatigue (24%), and a lack of disease- and drug-specific knowledge (64%). Further management was indicated for medication adherence counselling (48%), occupational therapy (43%), physiotherapy (36%) and podiatry (30%). Nearly half had current foot pain with 40% reporting DFP (n = 17), which caused significantly greater difficulty walking 3 km than those without DFP (p < 0.05). Rearfoot enthesitis (plantar fasciitis, Achilles enthesitis) was the most common cause of DFP (67%) with pain lasting longer than 1-year. 72% were overweight or obese, with a high proportion not engaging in any cardiovascular exercise (70%). Three of 42 participants had previously seen a podiatrist.

Conclusions
People with DFP in PsA experience more severe global disease activity, reduced mobility and higher levels of negative impact on their daily lives in Singapore. In the absence of working in a multidisciplinary-team, there is value in comprehensive assessments that have potential to capture a holistic view of personal impact and improve person-centred care in PsA.