bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimizers and EVEN
Authors: Shyu Shu-ing 
Published: November 2016

AbstractIt is widely acknowledged that polarity sensitivity pertains to the lexical nature of NPI minimizers, phrases denoting a minimal quantity, extent or degree. This paper, however, proposes that so-called “negative polarity” of Mandarin Chinese minimizers (yi-CL-N ‘one.CL+N’ andyidian-N ‘one.point N’) is not lexically determined, but is facilitated by utilizing the existinglian... dou‘including... all’ EVEN construction. Specifically, total negation is decomposed into a scalar operatorlian, which evokes a set of order ranked alternatives determined in context, and the maximizing/universal operatordou‘all’ that quantifies over the contextual alternatives plus the focused minimizer, which is placed at the end of the scale. The scalar minimizer syntactically scopes over the negation to represent the logic of ∀¬. This paper further distinguishes minimizers from lexical NPIrenhe‘any’ with respect to (i) scoping out of the negation for the former, (ii)beingirrelevant to the non-veridical licensing conditions that otherwise licenseanyand NPI-renhe, (iii) a clausemate relation betweendouand negation, and (iv) the lack of intervention effects of strong quantifiers between the minimizers and negation. The study lends further support to the claim that scalar EVEN is construed with minimizers. A comparison of Chinese minimizers with those in Hindi and Japanese has an implication for varieties of coding polarity ranging from purely lexical to syntactical means crosslinguistically.
High-performance Nanocavities-based Meta-crystals for Enhanced Plasmonic Sensing
Authors: Rippa M. , Castagna R. , Pannico M. , Musto P. , Bobeico E. , Zhou J. , Petti L. 
Published: November 2016

AbstractWe report on a novel procedure of fabrication to easily obtain highly reproducible nanocavities-shaped photonic crystals with strong plasmonic performances. Thus, we also report on the morphological and optical characterization of the obtained structures. They are classifiable as 2-layers (organic and inorganic) photonic crystals based on iso-Y-shaped nano-cavities. Such novel designed structures are compelling candidates for the development of highly sensitive biosensors due to their unique surface plasmon resonances (SPRs) and SPR enabled surface-enhanced Raman spectroscopy (SERS). The planar photonic crystal comprises a polymeric (ZEP520A) layer (thickness ~80 nm) sandwiched between a layer of gold (~50 nm thickness) and a glass substrate. For what concerns the cavities’ shape, iso-Y units are chosen on the basis of their third order nonlinearity and are coupled in hexagonal-based configuration to produce extended meta-structures. The substrates are functionalized with a probe made by a self-assembling monolayer (SAM) of 4-mercaptobenzoic acid (4-MBA). The average SERS Enhancement Factor >106 and SPR sensitivity of ~300 nm/RIU confirm that the proposed 2-layers iso-Y meta-structure is very suitable for high sensitive label-free plasmonic sensing.
Mounting Fans – Don’t Get in a Flap
Authors: Burt Yuki 
Published: November 2016

Abstract
Over the centuries, fans have been produced in a large range of shapes, styles, sizes and a variety and combination of materials. Each one, therefore, requires its own tailor-made mount, as poor display can cause severe damage. Long term display or storage in the open position, for instance, can lead to a fan becoming ‘set’ in that position, and if it can no longer be closed, its integrity is compromised. This article outlines some of the likely weaknesses of fans and the way in which they can deteriorate if not properly supported while on display. The vulnerabilities inherent in fans with a paper element are, more often than not, equally applicable to those incorporating other materials such as vellum or textiles. An understanding of the potential causes of degradation will guide good mount design and display practices.
Antenatal characteristics of Roma female population in Virovitica-Podravina County, Croatia
Authors: Šegregur Jadranko , Šegregur Domagoj 
Published: November 2016

AbstractIntroductionThis study reports about antenatal characteristics of Roma minority population. The study was designed to investigate data about health behaviours known to be associated with reproductive outcomes of Roma women that have very good living conditions and relatively high resource availability.MethodsA retrospective study included 204 Roma and 408 non-Roma hospitalised singleton births that occurred in the Maternity Ward of the General Hospital Virovitica in the period from 1991 to 2010. Data about women’s age, marital status, smoking, reproductive health (abortions, delivery), antenatal care, perinatal complications and gestational age were taken from hospital records and analysed.ResultsRoma women were averagely more than three years younger than non-Roma women, only 10.8% were married. Smoking was more frequent. The average number of births of Roma and non-Roma women was similar, averagely two children per woman. The rate of induced abortions in the Roma women was higher, while the frequency of spontaneous abortions was equal. Inadequate antenatal care of Roma women was associated with two times higher incidence of perinatal complications. A higher frequency of deliveries at home without professional assistance in Roma pregnancy resulted in lower perinatal outcomes. It was confirmed that Roma mothers give birth earlier (38+6 vs. 39+4 weeks) and have a higher incidence of premature births (9.3% vs. 2.2%).ConclusionsIn the comparison of antenatal parameters between the two researched groups, poorer prenatal outcomes in the Roma population were found, despite full integration and considerable improvement in living standards of this ethnic Roma population.
The influence of parental education and other socio-economic factors on child car seat use
Authors: Rok Simon Mateja , Korošec Aleš , Bilban Marjan 
Published: November 2016

Abstract

Introduction
The behaviour of parents in ensuring car passenger safety for their children is associated with socio-economic (SE) status of the family; however, the influence of parental education has rarely been researched and the findings are contradictory. The aim of the study was to clarify whether parental education influences the use of a child car seat during short rides.

Methods
A cross-sectional survey was carried out in outpatient clinics for children’s healthcare across Slovenia. 904 parents of 3-year-old children participated in the study; the response rate was 95.9%. A self-administered questionnaire was used. A binary multiple logistic regression was applied to assess the association between parental unsafe behaviour as dependent variable, and education and other SE factors as independent variables.

Results
14.6% of parents did not use a child car seat during short rides. Families where mother had low or college education had higher odds of the non-use of a child car seat than families where mother had a university education. Single-parent families and those who lived in areas with low or medium SE status also had higher odds of the non-use of a child car seat.

Conclusions
Low educational attainment influences parents’ behaviour regarding the non-use of a child car seat. Low parental education is not the only risk factor since some highly educated parents also have high odds of unsafe behaviour. All parents should therefore be included in individually tailored safety counselling programmes. SE inequalities could be further reduced with provision of free child car seats for eligible families.
Effects of resveratrol on diabetes-induced vascular tissue damage and inflammation in male rats
Authors: Pektaş Ayhan , Pektaş Mehmet Bilgehan , Koca Halit Buğra , Tosun Murat , Aslan Esra , Koca Selcan , Sadi Gökhan 
Published: November 2016

Abstract

Objective
The present study aims to investigate the short-term effects of resveratrol on histopathological characteristics and inflammatory cytokines of the heart and thoracic aorta tissues in animal models of streptozotocin (STZ)-induced diabetes.

Methods
Male Wistar rats were randomly divided into four groups; (1) control/vehicle, (2) control/20 mg/kg resveratrol, (3) diabetic/vehicle, (4) diabetic/20 mg/kg resveratrol. Heart and thoracic aorta were examined histopathologically and the levels of interleukin (IL)-1β, IL-18 and tissue necrosis factor (TNF)-α were analyzed by ELISA. Malondialdehyde (MDA) contents were determined with HPLC.

Results
Diabetes group had significantly higher vascular MDA content (p<0.05) as compared with the control and resveratrol treated groups. Resveratrol significantly reduced vascular MDA level in diabetic animals (p<0.05). Significant elevation in IL-1β and TNF-α contents in thoracic aorta and IL-18 contents in cardiac and arterial tissues with diabetes were almost normalized with resveratrol treatment. Additionally, diabetic animals demonstrated significant endothelial damage, irregularities in smooth muscle fibers and degeneration of elastic fibers in thoracic aortas together with significant irregularities and hypertrophy in cardiac muscle fibers. Resveratrol significantly improved most of these histopathological alterations.

Conclusion
Four-week-long intraperitoneal administration of resveratrol may restore the diabetes related inflammation and oxidative stress within the cardiovascular system.
Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure–activity relationships of the 1-aryl group and 9-position
Authors: Mohamed Hany M. , Fouda Ahmed M. , Khattab Essam S.A.E.H. , Agrody Ahmed M. El- , Afifi Tarek H. 
Published: November 2016

Abstract
A series of 1H-benzo[f]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring at 1-position of 1H-benzo[f]chromene nucleus with the specific group, H atom, or methoxy group at 9-position increases the ability of the molecule against the different cell lines.
Clinical Research Informatics for Big Data and Precision Medicine
Authors: Kahn M.G. , Weng C. 
Published: November 2016

Summary
Objectives: To reflect on the notable events and significant developments in Clinical Research Informatics (CRI) in the year of 2015 and discuss near-term trends impacting CRI.
Methods: We selected key publications that highlight not only important recent advances in CRI but also notable events likely to have significant impact on CRI activities over the next few years or longer, and consulted the discussions in relevant scientific communities and an online living textbook for modern clinical trials. We also related the new concepts with old problems to improve the continuity of CRI research.
Results: The highlights in CRI in 2015 include the growing adoption of electronic health records (EHR), the rapid development of regional, national, and global clinical data research networks for using EHR data to integrate scalable clinical research with clinical care and generate robust medical evidence. Data quality, integration, and fusion, data access by researchers, study transparency, results reproducibility, and infrastructure sustainability are persistent challenges.
Conclusion: The advances in Big Data Analytics and Internet technologies together with the engagement of citizens in sciences are shaping the global clinical research enterprise, which is getting more open and increasingly stakeholder-centered, where stakeholders include patients, clinicians, researchers, and sponsors.
Methods for Addressing Technology-induced Errors: The Current State
Authors: Dexheimer J. W. , Cossio C. Hullin Lucay , Gong Y. , Jensen S. , Kaipio J. , Kennebeck S. , Kirkendall E. , Kushniruk A. W. , Kuziemsky C. , Marcilly R. , Röhrig R. , Saranto K. , Senathirajah Y. , Weber J. , Takeda H. , Borycki E. 
Published: November 2016

SummaryObjectives: The objectives of this paper are to review and discuss the methods that are being used internationally to report on, mitigate, and eliminate technology-induced errors.Methods: The IMIA Working Group for Health Informatics for Patient Safety worked together to review and synthesize some of the main methods and approaches associated with technology-induced error reporting, reduction, and mitigation. The work involved a review of the evidence-based literature as well as guideline publications specific to health informatics.Results: The paper presents a rich overview of current approaches, issues, and methods associated with: (1) safe HIT design, (2) safe HIT implementation, (3) reporting on technology-induced errors, (4) technology-induced error analysis, and (5) health information technology (HIT) risk management. The work is based on research from around the world. Conclusions: Internationally, researchers have been developing methods that can be used to identify, report on, mitigate, and eliminate technology-induced errors. Although there remain issues and challenges associated with the methodologies, they have been shown to improve the quality and safety of HIT. Since the first publications documenting technology-induced errors in healthcare in 2005, we have seen in a short 10 years researchers develop ways of identifying and addressing these types of errors. We have also seen organizations begin to use these approaches. Knowledge has been translated into practice in a short ten years whereas the norm for other research areas is of 20 years.
The Virtuous Circles of Clinical Information Systems: a Modern Utopia
Authors: Degoulet P. 
Published: November 2016

Summary
Context: Clinical information systems (CIS) are developed with the aim of improving both the efficiency and the quality of care.
Objective: This position paper is based on the hypothesis that such vision is partly a utopian view of the emerging eSociety.
Methods: Examples are drawn from 15 years of experience with the fully integrated Georges Pompidou University Hospital (HEGP) CIS and temporal data series extracted from the data warehouses of Assistance Publique - Hôpitaux de Paris (AP-HP) acute care hospitals which share the same administrative organization as HEGP. Three main virtuous circles are considered: user satisfaction vs. system use, system use vs. cost efficiency, and system use vs quality of care.
Results: In structural equation models (SEM), the positive bidirectional relationship between user satisfaction and use was only observed in the early HEGP CIS deployment phase (first four years) but disappeared in late post-adoption (≥8 years). From 2009 to 2013, financial efficiency of 20 AP-HP hospitals evaluated with stochastic frontier analysis (SFA) models diminished by 0.5% per year. The lower decrease of efficiency observed between the three hospitals equipped with a more mature CIS and the 17 other hospitals was of the same order of magnitude than the difference observed between pediatric and non-pediatric hospitals. Outcome quality benefits that would bring evidence to the system use vs. quality loop are unlikely to be obtained in a near future since they require integration with population-based outcome measures including mortality, morbidity, and quality of life that may not be easily available.
Conclusion: Barriers to making the transformation of the utopian part of the CIS virtuous circles happen should be overcome to actually benefit the emerging eSociety.
Building a Privacy, Ethics, and Data Access Framework for Real World Computerised Medical Record System Data: A Delphi Study
Authors: Liyanage H. , Liaw S.-T. , Di Iorio C. T. , Kuziemsky C. , Schreiber R. , Terry A. L. , de Lusignan S. 
Published: November 2016

Summary
Background: Privacy, ethics, and data access issues pose significant challenges to the timely delivery of health research. Whilst the fundamental drivers to ensure that data access is ethical and satisfies privacy requirements are similar, they are often dealt with in varying ways by different approval processes. Objective: To achieve a consensus across an international panel of health care and informatics professionals on an integrated set of privacy and ethics principles that could accelerate health data access in data-driven health research projects.
Method: A three-round consensus development process was used. In round one, we developed a baseline framework for privacy, ethics, and data access based on a review of existing literature in the health, informatics, and policy domains. This was further developed using a two-round Delphi consensus building process involving 20 experts who were members of the International Medical Informatics Association (IMIA) and European Federation of Medical Informatics (EFMI) Primary Health Care Informatics Working Groups. To achieve consensus we required an extended Delphi process.
Results: The first round involved feedback on and development of the baseline framework. This consisted of four components: (1) ethical principles, (2) ethical guidance questions, (3) privacy and data access principles, and (4) privacy and data access guidance questions. Round two developed consensus in key areas of the revised framework, allowing the building of a newly, more detailed and descriptive framework. In the final round panel experts expressed their opinions, either as agreements or disagreements, on the ethics and privacy statements of the framework finding some of the previous round disagreements to be surprising in view of established ethical principles.
Conclusion: This study develops a framework for an integrated approach to ethics and privacy. Privacy breech risk should not be considered in isolation but instead balanced by potential ethical benefit.
A Survey of the Literature on Unintended Consequences Associated with Health Information Technology: 2014–2015
Authors: Abraham J. , Novak L. L. , Reynolds T. L. , Gettinger A. , Zheng K. 
Published: November 2016

SummaryObjective: To summarize recent research on unintended consequences associated with implementation and use of health information technology (health IT). Included in the review are original empirical investigations published in English between 2014 and 2015 that reported unintended effects introduced by adoption of digital interventions. Our analysis focuses on the trends of this steam of research, areas in which unintended consequences have continued to be reported, and common themes that emerge from the findings of these studies.Method: Most of the papers reviewed were retrieved by searching three literature databases: MEDLINE, Embase, and CINAHL. Two rounds of searches were performed: the first round used more restrictive search terms specific to unintended consequences; the second round lifted the restrictions to include more generic health IT evaluation studies. Each paper was independently screened by at least two authors; differences were resolved through consensus development.Results: The literature search identified 1,538 papers that were potentially relevant; 34 were deemed meeting our inclusion criteria after screening. Studies described in these 34 papers took place in a wide variety of care areas from emergency departments to ophthalmology clinics. Some papers reflected several previously unreported unintended consequences, such as staff attrition and patients’ withholding of information due to privacy and security concerns. A majority of these studies (71%) were quantitative investigations based on analysis of objectively recorded data. Several of them employed longitudinal or time series designs to distinguish between unintended consequences that had only transient impact, versus those that had persisting impact. Most of these unintended consequences resulted in adverse outcomes, even though instances of beneficial impact were also noted. While care areas covered were heterogeneous, over half of the studies were conducted at academic medical centers or teaching hospitals. Conclusion: Recent studies published in the past two years represent significant advancement of unintended consequences research by seeking to include more types of health IT applications and to quantify the impact using objectively recorded data and longitudinal or time series designs. However, more mixed-methods studies are needed to develop deeper insights into the observed unintended adverse outcomes, including their root causes and remedies. We also encourage future research to go beyond the paradigm of simply describing unintended consequences, and to develop and test solutions that can prevent or minimize their impact.
Some Innovative Approaches for Public Health and Epidemiology Informatics
Authors: Toubiana L. , Griffon N. ,   Section Editors for the IMIA Yearbook Section on Public Health and Epidemiology Informatics
Published: November 2016

Summary
Objectives: Summarize excellent current research published in 2015 in the field of Public Health and Epidemiology Informatics.
Methods: The complete 2015 literature concerning public health and epidemiology informatics has been searched in PubMed and Web of Science, and the returned references were reviewed by the two section editors to select 14 candidate best papers. These papers were then peer-reviewed by external reviewers to allow the editorial team an enlightened selection of the best papers.
Results: Among the 1,272 references retrieved from PubMed and Web of Science, three were finally selected as best papers. The first one presents a language agnostic approach for epidemic event detection in news articles. The second paper describes a system using big health data gathered by a statewide system to forecast emergency department visits. The last paper proposes a rather original approach that uses machine learning to solve the old issue of outbreak detection and prediction.
Conclusions: The increasing availability of data, now directly from health systems, will probably lead to a boom in public health surveillance systems and in large-scale epidemiologic studies.
Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans
Authors: Zhang Cecilia J , Bidlingmaier Martin , Altaye Mekibib , Page Laura C , D’Alessio David , Tschöp Matthias H , Tong Jenny 
Published: November 2016

ObjectiveTo compare the effects of acyl ghrelin (AG) and desacyl ghrelin (DAG) on blood pressure (BP), heart rate (HR) and other autonomic parameters in healthy humans and to elucidate the hormonal mechanisms through which AG could exert its cardiovascular effects.DesignSeventeen healthy participants underwent frequent monitoring of systolic (sBP) and diastolic blood pressure (dBP), HR, respiratory rate (RR) and body surface temperature (Temp) during continuous infusion of AG, DAG, combined AG + DAG or saline control before and during an IV glucose tolerance test on 4 separate days. Plasma catecholamines, renin and aldosterone levels were also measured. Differences in outcome measures between treatment groups were assessed using mixed-model analysis.ResultsCompared to the saline control, AG and combined AG + DAG infusions decreased sBP, dBP, mean arterial blood pressure (MAP), HR and Temp. In contrast, DAG infusion did not alter BP, RR or Temp, but did decrease HR. The AG and AG + DAG infusions also raised plasma aldosterone levels compared to saline (P < 0.001) without affecting renin or catecholamine levels.ConclusionsThe decrease in BP, HR, RR and Temp with AG infusion suggests mediation through the autonomic nervous system. The lack of response to DAG suggests that these autonomic effects require activation of the ghrelin receptor.