bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk tolerance and decision‐making processes of Australian women regarding medication trials in pregnancy
Authors: Quattrini Eva , Ireland Demelza J. , Keelan Jeffrey A. 
Published: September 2024

BackgroundPregnant women have historically been excluded from participation in medication trials, in part due to the perceived risks of drug exposure to mothers and fetuses. However, little is known about pregnant women's attitudes toward risk and participation in such trials.AimsTo address this knowledge gap and to identify factors that influence trial participation.Materials and methodsAustralian women over the age of 18, currently pregnant or within six months of delivery, were recruited to participate in an online survey (n = 623) and follow‐up interviews (n = 11). The survey investigated willingness to participate in five hypothetical drug trial scenarios of varying risk. Demographic and obstetric information, including COVID‐19 vaccination status, was also collected. The impact of these factors on trial participation was analysed using ordinal regression. Interviews were subjected to thematic framework analysis using a priori and emergent themes.ResultsNearly half of the respondents (48%) indicated a willingness to participate in at least one of the hypothetical trials. As trial risk increased participation likelihood decreased, especially if the risk was to the fetus, regardless of benefits to the mother. COVID‐19 vaccination status and medication hesitancy were predictors of an unwillingness to participate. Three broad themes emerged from the qualitative data: risk–benefit analysis, quality of evidence, and trust.ConclusionsOverall, participants expressed a positive attitude toward research and medication trials during pregnancy, but were concerned about fetal risk. The findings of this study may help enhance trial design and the participation of pregnant women in medication trials.
Significant kidney disease in pregnancy: Feasibility and outcomes of a national population‐based study using the Australasian Maternity Outcomes Surveillance System
Authors: Jesudason Shilpanjali , Safi Nadom , Li Zhuoyang , Brown Mark , Hague William , Makris Angela , McDonald Stephen , Peek Michael J. , Sullivan Elizabeth 
Published: September 2024

BackgroundCurrent understanding of clinical practice and care for maternal kidney disease in pregnancy in Australia is hampered by limitations in available renal‐specific datasets.AimsTo capture the epidemiology, management, and outcomes of women with significant kidney disease in pregnancy and demonstrate feasibility of a national cohort study approach.Materials and MethodsAn Australian prospective study (2017–2018) using a new kidney disease‐specific survey within the Australasian Maternity Outcomes Surveillance System (AMOSS). Women who gave birth with acute kidney injury (AKI), advanced chronic kidney disease (CKD), dialysis dependence or a kidney transplant were included. Demographic data, renal and obstetric management, and perinatal outcomes were collected.ResultsAmong 58 case notifications from 12 hospitals in five states, we included 23 cases with kidney transplant (n = 12), pre‐existing CKD (n = 8), newly diagnosed CKD (n = 2) and dialysis (n = 1). No cases of AKI were reported. Reporting rates were better in states with study investigators and, overall, cases were likely under‐reported. Nearly 35% of women had a non‐delivery‐related antenatal admission. Nephrology involvement was 78.3% during pregnancy and 91% post‐partum. Adverse events were increased, including pre‐eclampsia (21.7%), and preterm birth (60.9%). Women had high rates of aspirin (82.6%) and antihypertensive (73.9%) use, indwelling catheter for labour/delivery (65.2%), caesarean delivery (60.9%), and blood transfusion (21.7%).ConclusionsThis first‐ever Australian prospective study of significant kidney diseases in pregnancy provided novel insights into renal‐specific clinical patterns and practices. However, under‐reporting was likely. Future studies need to overcome the challenges of case identification and data collection burden.
Clinical utility analysis of the Hoxb8 mast cell activation test for the diagnosis of peanut allergy
Authors: Bachmeier‐Zbären Noemi , Celik Alper , van Brummelen Robin , Roos Nadine , Steinmann Melanie , Hoang Jennifer A. , Yin Xiaojun , Ditlof Christina M. , Duan Lucy , Upton Julia E. M. , Kaufmann Thomas , Eggel Alexander , Eiwegger Thomas ,   MONAS working group
Published: September 2024

AbstractBackgroundPeanut allergy is among the most severe and common food allergies. The diagnosis has a significant impact on the quality of life for patients and their families. An effective management approach depends on accurate, safe, and easily implementable diagnostic methods. We previously developed a cell‐based assay using Hoxb8 mast cells (Hoxb8 MCs) aimed at improving clinical allergy diagnosis. In this study, we assessed its diagnostic performance by measuring blinded sera from a prospectively enrolled and pre‐validated peanut allergy cohort.MethodsHoxb8 MCs were passively sensitized with sera from peanut‐allergic and peanut tolerant children and adolescents (n = 112). Degranulation of Hoxb8 MCs was quantified upon stimulation with dose‐titrated peanut extract by means of flow cytometry, using CD107a as activation marker. The results from the Hoxb8 mast cell activation test (Hoxb8 MAT) were compared to established diagnostic assays such as the skin prick test (SPT), specific IgE (sIgE) levels, and the basophil activation test (BAT). Additionally, serum samples from BAT nonresponders were assessed with the Hoxb8 MAT.ResultsHoxb8 MAT displayed a robust dose‐dependent activation to peanut extract, with a cutoff value of ≤5.2% CD107a positive cells. The diagnostic accuracy was highest at allergen concentrations ≥100 ng/mL, with an area under the receiver operating characteristic curve (AUROC) of 0.97, 93% sensitivity, and 96% specificity, outperforming traditional SPT and sIgE tests. When compared to BAT, Hoxb8 MAT exhibited comparable diagnostic efficacy. Moreover, sera from BAT nonresponders were accurately classified into allergics and nonallergics by the Hoxb8 MAT.ConclusionsThe Hoxb8 MAT demonstrated a very good diagnostic precision in patients prospectively assessed for peanut allergy comparable to the fresh whole blood‐based BAT. Additionally, it demonstrated its value for accurate classification of BAT nonresponders into allergic and nonallergic individuals. Further investigations into its utility in the routine clinical setting are warranted.
Full Bayesian analysis of triple seasonal autoregressive models
Authors: Amin Ayman A. 
Published: September 2024

SummarySeasonal autoregressive (SAR) time series models have been extended to fit time series exhibiting multiple seasonalities. However, hardly any research in Bayesian literature has been done on modelling multiple seasonalities. In this article, we propose a full Bayesian analysis of triple SAR (TSAR) models for time series with triple seasonality, considering identification, estimation and prediction for these TSAR models. In this Bayesian analysis of TSAR models, we assume the model errors to be normally distributed and the model order to be a random variable with a known maximum value, and we employ the g prior for the model coefficients and variance. Accordingly, we first derive the posterior mass function of the TSAR order in closed form, which then enables us to identify the best order of TSAR model as the order value with the highest posterior probability. In addition, we derive the conditional posteriors to be a multivariate normal for the TSAR coefficients and to be an inverse gamma for the TSAR variance; also, we derive the conditional predictive distribution to be a multivariate normal for future observations. Since these derived conditional distributions are in closed forms, we introduce the Gibbs sampler to present the Bayesian analysis of TSAR models and to easily produce multiple‐step‐ahead predictions. Using Julia programming language, we conduct an extensive simulation study, aiming to evaluate the accuracy of our proposed full Bayesian analysis for TSAR models. In addition, we apply our work on time series to hourly electricity load in some European countries.
Social cognitive consequences of leader artistic literacy
Authors: Duan Jinyun , Wang Tingxi , Xu Yue , Yin Yishuai 
Published: September 2024

AbstractDespite an increasing interest in developing leaders' artistic capacities to address the complexities and uncertainties of the business environment, there is a scarcity of empirical research on the interpersonal effects of those capacities. To fill this gap, we introduce the concept of “leader artistic literacy” (a leader's proficiency and understanding of various forms of art and their ability to incorporate artistic elements into their communication and behaviors when interacting with followers) and delve into its effects for subordinates. Drawing upon the warmth and competence framework and implicit leadership theory, we investigated how leaders' artistic literacy in different industries influences leadership effectiveness through social cognition of warmth and competence. The results of two experiments (Study 1: N = 146; Study 2: N = 209) with participants from different industries demonstrated that higher artistic literacy in art‐related industries leads to positive social cognition (warmth and competence perception), which in turn promotes subordinates' liking and perceived leaders' promotability. By contrast, in nonart‐related industries, higher artistic literacy may be detrimental to leaders. Theoretical and practical implications are discussed.
A valence and arousal circumplex examination of affect and creativity at work
Authors: Madrid Hector P. , Patterson Malcolm G. 
Published: September 2024

AbstractWhether and how affect is related to creativity is a central inquiry in work and organizational psychology. Research has demonstrated that, in general, both positive and negative feelings have the potential to foster the development of novel ideas in the workplace. Nevertheless, drawing on core affect theory, we argue that in addition to affective valence, arousal of feelings should also be taken in account, using a circumplex approach for a complete and finer‐grained approach to this phenomenon. Therefore, we revisit this question by asking Do affective experiences compounded of different blends of valence and arousal relate to creativity at work? Results of a diary study showed that the function of affect relative to creativity in the workplace could be positive, negative, or null depending on one of the 12 valence and arousal compounds examined. Theory and research developed here suggest that the interplay between affect and creativity is more complex than many scholars have believed, which has implications for affect management in organizations.
Conceptualization and measurement of Islamophobia: A systematic review
Authors: Kathawalla Ummul‐Kiram , Gulamhussein Quratulain , Chan Fei Bi , Riegelman Amy , Syed Moin 
Published: September 2024

AbstractThe term Islamophobia is used in research studies; however, it is evident many researchers do not similarly use the term and, subsequently, measure the construct. We evaluate measures based upon their alignment with one first definition of Islamophobia that includes: (1) a perceived fear or threat of Islam/Muslims and (2) an engagement in prejudicial attitudes and/or discriminatory actions. We conducted a systematic literature search of 15 databases to identify Islamophobia‐related measures used in the literature from 1992 to 2018 (updated 2022). The measures were reviewed to examine alignment with the definition of Islamophobia and their psychometric properties. We identified 12 validated measures of Islamophobia and provided an in‐depth review of each measure. Additionally, we cataloged the 249 validated and nonvalidated measures of Islamophobia (N = 24), and the five remaining content areas—prejudicial attitudes (N = 80), discriminatory actions (N = 21), fear of Muslims (N = 23), anti‐other group (N = 52), and experiences of discrimination for Muslims (N = 49) by validity, measure structure, and other criteria (Tables 1–12). This systematic review can assist researchers in identifying and selecting the most reliable and valid measure related to their definition of Islamophobia.
Percutaneous endoscopic intragastric surgery for gastric metastases of renal cell carcinoma: A case report
Authors: Hayashi Saki , Tsuji Toshikatsu , Tanaka Hiroyuki , Takenaka Shunsuke , Machi Ryosuke , Mitta Kazuyoshi , Doden Kenta , Suzuki Hayato , Shimada Mari , Saito Hiroto , Yamamoto Daisuke , Moriyama Hideki , Kinoshita Jun , Inaki Noriyuki 
Published: September 2024

AbstractTo our knowledge, this is the first report of percutaneous endoscopic intragastric surgery (PEIGS) for gastric metastases from other organs. A 70‐year‐old male with a history of renal cell carcinoma (RCC) was referred to our department for the treatment of gastric metastasis of RCC. Partial gastrectomy was performed using single‐incision PEIGS. Two years after the surgery, a follow‐up esophagogastroduodenoscopy revealed a tumor located on the middle greater curvature of the stomach. The diagnosis was metastatic renal cell carcinoma, prompting a similar surgery. No recurrence was observed after the second surgery. PEIGS is a minimally invasive option for the treatment of metastatic gastric tumors.
In vitro rumen fermentation characteristics of bakery by‐products containing high starch and sugar
Authors: Nayohan Sandi , Sekoguchi Miyu , Nishikawa Yoshimasa , Matamura Masaya , Jayanegara Anuraga , Matsui Hiroki , Kondo Makoto 
Published: September 2024

AbstractThe objectives of this study were to evaluate the nutritional characteristics of bakery by‐products (castella, pancake, baumkuchen) and their effect on rumen fermentation in vitro as compared with steam‐flaked corn and barley as human‐edible grains. The fermentation pattern of sugar and starch as pure components was also investigated. Additionally, rumen pH was evaluated using a low‐capacity buffer. Bakery by‐products contained high sugar (212–590 g/kg DM) and starch (262–545 g/kg DM). Castella exhibited the highest sugar content, whereas pancake and baumkuchen were rich in starch and ether extract within bakery by‐products, respectively. The gas production rate at the early phase of incubation was higher in bakery by‐products than in grains, and the highest in castella among all feeds. Bakery by‐products produced higher total organic acids and propionate than grains. Bakery by‐products also exhibited a lower rumen pH than grains during twenty‐four hours of incubation with a low‐capacity buffer. As pure components, sucrose showed a higher gas production rate and lower pH than starch. Overall, compared with grains, bakery by‐products have the potential not only to supply more energy to ruminants but also decrease rumen pH because sugar and starch in bakery by‐products ferment rapidly and produce higher organic acids in the rumen.
Experiencing enjoyment in visual programming tasks promotes self‐efficacy and reduces the gender gap
Authors: Smit Robbert , Schmid Rahel , Robin Nicolas 
Published: September 2024

AbstractSecondary school students (N = 269) participated in a daylong visual programming course held in a stimulating environment for start‐up enterprises. The tasks were application‐oriented and partly creative. For example, a wearable device with light‐emitting diodes, (ie, LEDs) could be applied to a T‐shirt and used for optical messages. Our research questions related to the control‐value model of achievement emotions. We measured experienced enjoyment four times and examined the dependence of enjoyment on the individual tasks. Experience of enjoyment was also tested for the prediction of students' self‐efficacy for programming. The results showed that momentary enjoyment was not significantly dependent on the task situation, but it was dependent on the general enjoyment of programming. However, students with lower enjoyment scores showed higher increases in enjoyment during the final tasks than those with higher initial scores. The emotion score of the girls increased more than those of the boys but the girls' overall enjoyment scores were lower than those of the boys. Students' self‐efficacy beliefs of both genders increased over the course, and some of the differences in beliefs can be explained by the enjoyment of the course. In conclusion, our teaching approach seemed beneficial for the motivation to learn programming, particularly among girls.
Practitioner notesWhat is already known about this topic

Lower secondary students often report a lack of self‐efficacy beliefs for visual programming, especially girls whose confidence in their abilities seems to be missing.
Activities that show how programming can be used in everyday life or at work promote interest and enjoyment, especially among girls.
What this paper adds

Experiencing enjoyment did not depend on individual task types (more structured vs. more open), but proved to be stable across all tasks.
The experience of positive emotions in our computer science course had an impact on the secondary school students' self‐efficacy beliefs.
Implications for practice and/or policy

The combination of smart textiles and programming was viewed as a motivating learning experience with the potential to foster secondary school students' confidence and problem‐solving skills in computer science.
A guided sequence of learning to debug can provide a self‐enhancing foundation for the students' own activities with following tasks that are more open and creative approaches.
Mega‐dose decitabine conditioning and prophylactic donor lymphocyte infusion for patients with relapsed/refractory AML with active disease at the time of allogeneic haematopoietic cell transplantation: A multicenter prospective phase II study
Authors: Lv Meng , Yan Chen‐Hua , Ma Rui , He Yun , Zhang Yuan‐Yuan , Wang Zhi‐Dong , Chen Yu‐Hong , Han Wei , Kong Jun , Han Ting‐Ting , Liu Jing , Zheng Hao , Mo Xiao‐Dong , Sun Yu‐Qian , Wang Yu , Xu Lan‐Ping , Zhang Xiao‐Hui , Huang Xiao‐Jun 
Published: September 2024

SummaryPatients with relapsed/refractory acute myeloid leukaemia (R/R AML), especially those who failed in novel target agents are related to dismal survival. We developed a multi‐institutional, single‐arm, prospective phase II trial, to investigate intensified conditioning with ‘Mega‐Dose’ decitabine (MegaDAC) following allogeneic haematopoietic cell transplantation (allo‐HCT) for R/R AML. From 2019 to 2023, 70 heavily treated R/R AML patients in active disease were consecutively enrolled. Significantly, every patient (n = 18) harbouring specific mutations exhibited no response to their best available target agents (BATs). Moreover, 74.3% of the enrolled patients did not reach remission following venetoclax‐based regimens. All patients underwent intravenous decitabine (400 mg/m2) along with busulfan and cyclophosphamide. Median follow‐up was 26 months (8–65) after HCT. All engrafted patients achieved MRD negativity post‐HCT, with a median 3.3‐log reduction in recurrent genetic abnormalities. The regimen was well tolerated, without irreversible grades III–IV toxicity peri‐engraftment. The estimated 2‐year CIR was 29.6% (18.4%–41.7%) and the est‐2‐year NRM was 15.5% (7.8%–25.5%). The est‐2‐year LFS, OS, and GRFS were 55.0% (43.5%–69.4%), 58.6% (47.0%–73.0%), and 42.9% (31.9%–57.6%), respectively. Multivariate analysis showed that pre‐HCT drug exposures had no significant impact on primary outcomes. MegaDAC is highlighted as an effective and safe option for R/R AML in the new era of targeted therapies.
Impact of Glycine Powder Air‐Abrasive Debridement on Peri‐Implant Mucositis: A Randomized Control Trial of Clinical, Microbial, and Immunological Changes
Authors: Partido Brian , Saraswat Shweta , Kumar Purnima S. 
Published: September 2024

ABSTRACTAimPeri‐implant mucositis, a dysbiosis‐driven inflammatory disease, is a precursor to peri‐implantitis, underscoring the need for early disease management. Therefore, we investigated the efficacy of glycine powder in resolving clinical inflammation and restoring host‐microbial homeostasis.MethodsThirty subjects were randomized to receive either glycine powder air‐abrasive debridement or ultrasonic instrumentation. Clinical parameters (probe depth [PD], modified Sulcular Bleeding Index [mSBI], modified Plaque Index [mPlI]), biofilm and peri‐implant crevicular fluid were collected at baseline and at 1‐day, 1‐, 3‐, 6‐weeks and 3‐ and 6‐months post‐therapy. Microbial recolonization was examined using 16S rDNA sequencing and immune response was semi‐quantified using a bead‐based 17‐plex microarray.ResultsAt 6‐months, both groups demonstrated non‐significant reductions in mSBI when compared to baseline (p > 0.05, Wald test, mixed model for repeated measures). However, mSBI and PD decreased in the test group from week‐1 to 3‐months, while control group decreased at 1‐ and 3‐weeks only. mSBI was lower in the test group when compared to controls from Week‐1 to 3‐months, while PD differed between groups at 6 weeks and 3‐months. Glycine group demonstrated significant microbial shifts after 24‐h, increases in species richness and health‐compatible species, and loss of pathobionts (p < 0.001, Dunn test). Pro‐inflammatory cytokines decreased from 1‐ to 6‐weeks or 3‐months (p < 0.05, Wald test). Comparable results were obtained in the ultrasonic group at 3‐weeks and sustained over 6‐weeks post‐therapy.ConclusionsGlycine therapy leads to early and sustained change in host‐microbial interactions when compared to ultrasonics, however, the changes wrought by both therapies were sustained for a maximum of 3 months.Trial RegistrationClinicalTrials.gov identifier: NCT05810558
Cross‐reactivity between thiuram disulfides and dithiocarbamates. A study of TETD and ZDEC using mouse models
Authors: Kursawe Larsen Christoffer , Funch Anders Boutrup , Vaher Helen , Lohmann Rebecca Kitt Davidson , Jee Mia Hamilton , Schwensen Jakob F. B. , Zachariae Claus , Svedman Cecilia , Bergendorff Ola , Bonefeld Charlotte Menné , Johansen Jeanne D. 
Published: September 2024

AbstractBackgroundRubber accelerators are used in the vulcanization of rubber. However, rubber accelerators for example tetraethylthiuram disulfide (TETD) and zinc diethyldithiocarbamate (ZDEC) may cause contact allergy. Concomitant reactions between ZDEC and TETD have been observed in patients which could be explained by co‐ or cross‐reactivity.ObjectivesTo investigate cross‐reactivity between TETD and ZDEC and vice versa.MethodsGroups of mice were sensitized with TETD or ZDEC based on reported EC3‐values. Proliferation of lymphocytes were measured on day 5. To test cross‐reactivity, mice were sensitized and challenged 3 weeks later with TETD or ZDEC. The inflammatory response was measured by changes in ear thickness and the proliferative response in CD4+ and CD8+ T cells in the submandibular and cervical draining lymph nodes.ResultsSensitization of mice with doses of ZDEC 3%, TETD 5.6% or TETD 16.2% induced significant increased ear thickness and proliferation of CD4+ and CD8+ T cells. Challenge with ZDEC or TETD in these groups induced significant increased ear thickness. Challenge with ZDEC in mice sensitized to TETD 5.6% or TETD 16.2% induced significant increased proliferation of CD4+ and CD8+ T cells.ConclusionsWe show cross‐reactivity between TETD and ZDEC. Patients sensitized to TETD or ZDEC should avoid exposure to both ZDEC and TETD.