bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of antenatalChlamydia trachomatisandNeisseria gonorrhoeaescreening on postdelivery prevalence and vertical transmission in Gaborone, Botswana: findings from an exploratory study
Authors: Mussa Aamirah , Wynn Adriane , Ryan Rebecca , Babalola Chibuzor M , Hansman Emily , Simon Selebaleng , Bame Bame , Moshashane Neo , Masole Maitumelo , Wilson Melissa L , Klausner Jeffrey D , Morroni Chelsea 
Published: October 2024

ObjectivesChlamydia trachomatisandNeisseria gonorrhoeaeare common sexually transmitted infections (STIs). Untreated infection in pregnancy can result in adverse neonatal outcomes, including vertical transmission. Screening for these infections is not routine in low- and middle-income countries (LMICs).MethodsThe Maduo Study was a non-randomised cluster crossover trial in Botswana to provide preliminary data on the effect of antenatalC. trachomatisandN. gonorrhoeaescreening and treatment on postdelivery prevalence and vertical transmission to infants. Pregnant women asymptomatic for STIs were enrolled at four clinics (seven clusters). The intervention arm receivedC. trachomatisandN. gonorrhoeaescreening at first antenatal care, third trimester and postdelivery. The standard-of-care arm received postdelivery screening only. Infants of women with a positive test postdelivery in both arms were screened. A cluster-level analysis was performed to compare the risk of postdelivery infection between intervention and standard-of-care arms.ResultsThe study enrolled 500 women; 206 (82.1%) and 187 (75.1%) were retained in the intervention and standard-of-care arms, respectively and screened ≤12 weeks postdelivery.C. trachomatisprevalence in the intervention arm reduced from 22.7% at first antenatal care to 1.0% postdelivery.N. gonorrhoeaeprevalence reduced from 1.2% at first antenatal care to 0% postdelivery. The risk ofC. trachomatisand/orN. gonorrhoeaewas lower in the intervention arm postdelivery (0.6%) compared with the standard-of-care arm (15.7%); adjusted risk difference: −14.7% (95% CI −23.0%, −6.4%). Among 26 infants born to women with either infection postdelivery, 10 (38.5%) tested positive (C. trachomatis: 9;N. gonorrhoeae: 1).ConclusionsPostdelivery prevalence ofC. trachomatiswas significantly lower among pregnant women in Botswana who received diagnostic antenatal screening. Among women withC. trachomatisand/orN. gonorrhoeaepostdelivery, more than one-third transmitted the infection to their infants. This exploratory study suggests antenatal STI screening has the potential to reduce infection in newborns in similar LMIC settings.Trial registration numberNCT04955717.
A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study
Authors: Vandenberghe Camille , Hardy Elisabelle , Morin Marie Christine , St-Pierre Valérie , Groulx Karine , Fortier Mélanie , Tessier Daniel , Leclerc Paul , Cunnane Stephen C. 
Published: October 2024

Poor glucose regulation associated with gradual insulin resistance is a significant risk factor in several age-related chronic diseases. An eating plan that promotes a lower carbohydrate intake may have a beneficial effect on glucose metabolism. This study aimed to evaluate how a diet reduced in carbohydrate by 32% (RCHO) over a 2 month period would influence the metabolic profile of older individuals ( N = 24) living in a retirement home (RH). A continuous glucose monitor was used to measure blood glucose during four periods: the standard diet before (baseline) and after (washout) the intervention, during the 4 initial days of the RCHO diet (RCHO-early), and the final days of the 2 month intervention (RCHO-end). The blood metabolic profile was also measured (glucose, ketones, insulin, triglycerides, and cholesterol). RCHO intake decreased average blood glucose compared to the standard diet in hyperglycemic participants: RCHO-early 7.8 ± 1.0 vs 7.5 ± 1.1 mM ( p = 0.012) and RCHO-end 7.8 ± 1.0 vs 7.0 ± 0.9 mM ( p = 0.050). In the hyperglycemic participants, the percentage of time spent in hyperglycemia (>10.0 mM) decreased by 50% during the RCHO-early ( p = 0.012) and by 66% at RCHO-end ( p = 0.021) compared to baseline. Glycated hemoglobin was significantly lower at RCHO-end in both hyperglycemic and normoglycemic participants compared to baseline ( p < 0.008). Plasma ketones increased threefold in hyperglycemic participants at RCHO-end compared to baseline ( p < 0.028). This study shows that an RCHO diet has metabolic health benefits in an older population and confirms its safety, tolerability, and acceptability in an RH (NCT06022094).
Outbreak Response to Circulating Vaccine‐Derived Poliovirus in Three Northern Regions of Ghana, 2019
Authors: Odoom John Kofi , Dzotse Emmanuel Kofi , Nii-Trebi Nicholas Israel , Opare David , Akyereko Ernest , Attiku Keren , Duker Ewurabena Oduma , Eshun Miriam , Boahene Bismarck Banahene , Gberbi Emmanuel , Houphouet Ekua Essumanma , Diamenu Stanley , Adjabeng Michael , Asamoah-Frimpong Joseph , Ameme Donne , Opare Joseph Kojo Larbi , Obodai Evangeline 
Published: October 2024

Background: Circulating Vaccine‐Derived Poliovirus Type 2 (cVDPV2) was isolated in sewage and later in stool samples from children with acute flaccid paralysis (AFP) in northern Ghana.Method: A multidisciplinary and multisectoral team investigated this outbreak and reported on epidemiological and laboratory investigations. Sewage/wastewater samples were collected from the environment, while stool samples were collected from AFP/contact children under 5 years of age. The samples were processed for virus isolation, and positive isolates were sequenced. We also conducted a descriptive investigation involving a review of records, active case search, and Monovalent Oral Polio Vaccine 2 campaigns. Additionally, we interviewed caregivers about the vaccination status of their children, as well as their knowledge on polio prevention. Water quality, sanitation, hygiene practices, and health‐seeking behaviours were also assessed.Results: A total of 18 cVDPV2 were confirmed in the three regions of Ghana during the outbreak in 2019–2020. All strains were genetically linked to a Nigerian cVDPV2 strain NIE‐KWS‐KSB‐18‐006HC29 that circulated in 2018. Evaluation of the surveillance system shows that officers have good knowledge of AFP and know how to collect samples, package them, and ship them to the laboratory. Few communities had access to potable water. Open defecation was common, and the water supply, sanitation, and hygiene practices of the communities were poor.Conclusion: The cVDPV2 outbreak represents the first time cVDPV2 has circulated in the country since Ghana embarked on the polio eradication program in 1996. However, with quality mOPV2 mop‐up campaigns, a nationwide IPV catch‐up campaign coupled with enhanced surveillance measures, transmission was interrupted.
Cross‐Validation of Paranoid and Depressive Scales: Results From Functional MRI Group Independent Component Analysis
Authors: Stoyanov Drozdstoy , Paunova Rossitsa , Najar Diyana , Zlateva Gabriela , Kandilarova Sevdalina , Khorev Vladimir , Kurkin Semen A. 
Published: October 2024

Objective: Based on earlier research, we hypothesized that patient response to diagnostically relevant items (paranoid (DP) and depressive (DS)) from clinical self‐assessment scale (PD‐S) could be cross‐validated when performed simultaneously with task‐based fMRI, resulting in specific and common neural circuit activations in response to the PDS items. In the current study, we tried to overcome one of the limitations of our previous research, namely, the lack of a healthy control (HC) group. Thus, our aim was to investigate the possible differences between patients with schizophrenia (SCZ) and depression and HCs using independent component analysis.Methods: A total of 72 subjects participated in this study, including 21 HCs, 26 patients with SCZ, and 25 patients with major depressive episode (DEP). Patients were scanned on a 3Т MRI system using a functional MRI task representing statements from DP‐DS scale and diagnostically neutral (DN) statements. The data were processed using group independent component analysis for fMRI toolbox (GIFT).Results: Five components were identified as task‐related, but only three of them were found to demonstrate statistical difference between SCZ, DEP, and HC, namely, components 6, 7, and 9. The contrast between SCZ and HC was presented by Component 6 (cingulate gyrus and basal ganglia), which exhibited significant difference when comparing all three active conditions. On the other hand, SCZ and DEP group differences were presented by Component 7 for DS‐DN comparison (frontoparietal network and superior temporal gyrus) and Component 9 (medial frontal gyrus, precuneus, angular gyrus, and among others) which highlighted preferential processing related to the DP‐DN and the DS‐DP comparison.Conclusion: Our results demonstrate differences in brain circuits processing preferentially diagnostic stimuli across the three groups. Those circuits involve mainly networks of cognitive and affective functioning, which provides insights in their role for pathophysiology of SCZ and DEP. This evidence fosters the theory of transdisciplinary validation, where neurobiological measure such as functional MRI is determined as external validity operation for the diagnostic assessment scales. This can facilitate the use of clinical evaluation methods as proxy measures of brain functions.
LSD1 and CoREST2 Potentiate STAT3 Activity to Promote Enteroendocrine Cell Differentiation in Mucinous Colorectal Cancer
Authors: Ladaika Christopher A. , Ghobashi Ahmed H. , Boulton William C. , Miller Samuel A. , O’Hagan Heather M. 
Published: October 2024

Abstract
Neuroendocrine cells have been implicated in therapeutic resistance and worse overall survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for enteroendocrine cells (EEC), the neuroendocrine cells of the normal colon epithelium, as compared with non-mCRC. Therefore, targeting EEC differentiation may have clinical value in mCRC. In this study, single-cell multiomics uncovered epigenetic alterations that accompany EEC differentiation, identified STAT3 as a regulator of EEC specification, and discovered a rare cancer-specific cell type with enteric neuron–like characteristics. Furthermore, lysine-specific demethylase 1 (LSD1) and CoREST2 mediated STAT3 demethylation and enhanced STAT3 chromatin binding. Knockdown of CoREST2 in an orthotopic xenograft mouse model resulted in decreased primary tumor growth and lung metastases. Collectively, these results provide a rationale for developing LSD1 inhibitors that target the interaction between LSD1 and STAT3 or CoREST2, which may improve clinical outcomes for patients with mCRC.
Significance: STAT3 activity mediated by LSD1 and CoREST2 induces enteroendocrine cell specification in mucinous colorectal cancer, suggesting disrupting interaction among LSD1, CoREST2, and STAT3 as a therapeutic strategy to target neuroendocrine differentiation.
Ethnographies of Unimagined Possibilities: Toward a Conversational Paradigm for Human-Centered Design Research
Authors: Celikoglu Ozge Merzali , Krippendorff Klaus 
Published: October 2024

Abstract
Relying on Krippendorff's description of “authentic conversation” we describe the ethnography of unimagined possibilities in the intersection of ethnography and human-centered design research. Possibilities are what inspire human-centered designers to create products, practices, and services that could satisfy currently unimagined yet real needs and desires. Although possibilities are not observable as such, they can be constructed in conversations of designers and other stakeholders. Hence, they can become extensions of real situations that are co-constructed as new realities.
A default mode network subsystem supports both item and associative word encoding: Insights from a meta-analysis
Authors: Kim Hongkeun 
Published: October 2024

Abstract
Recent meta-analytic evidence has underscored the significant role of the default mode network (DMN) in facilitating item word encoding. This study builds on this finding through a comprehensive meta-analysis of fMRI-based subsequent memory studies that use words as stimuli. The results highlight several key functions within the DMN. Firstly, the dorsomedial prefrontal cortex (dmPFC) subsystem of the DMN plays a pivotal role in enhancing successful word encoding, suggesting its vital involvement in the semantic processing of incoming verbal information. Secondly, the utility of the dmPFC subsystem extends beyond item word encoding to associative word encoding tasks, demonstrating its broad applicability in verbal information encoding. Thirdly, regions within the left inferior frontal cortex, a core component of the dmPFC subsystem, show increased activity during associative compared to item word encoding, emphasizing their role in integrating verbal information with contextual details. Contrary to previous research that linked the DMN with encoding interference—often attributed to the core subsystem’s tendency for mind-wandering—this study highlights the facilitative role of the dmPFC subsystem in memory encoding. The contrasting roles of the DMN subsystems, both interfering and facilitating, challenge traditional views and advocate for a more nuanced understanding of the network’s role in memory encoding.
Cerebral artery and brain pathology correlates of antemortem cerebral artery 4D flow MRI
Authors: Schroeder Brooke E. , Rivera-Rivera Leonardo A. , Barger Madeleine R. , de Chavez Elena Ruiz , Ospina-Romero Monica , Langhough Rebecca E. , Teague Jordan P. , Carey Finnuella J. , Asthana Sanjay , Johnson Sterling C. , Johnson Kevin M. , Eisenmenger Laura , Wieben Oliver , Salamat M. Shahriar , Betthauser Tobey J. 
Published: October 2024

Abstract
Large-scale clinical research studies often incorporate neuroimaging biomarkers to understand underlying pathologic changes that occur in aging and neurodegenerative disease and are associated with cognitive decline and clinical impairment. Of particular interest are neuroimaging methods designed to understand various aspects of cerebrovascular disease that can lead to dementia and also co-occur with neurodegenerative diseases such as Alzheimer’s disease. Neurovascular 4D flow magnetic resonance imaging is one such method that measures hemodynamic characteristics of medium-large cerebral vessels, but it remains unclear how measures derived from 4D flow imaging including pulsatility index, cerebral blood flow, and cross-sectional area relate to underlying pathologic changes in cerebral arteries and downstream cerebrovascular pathology. For example, pulsatility index is thought to be a marker of vessel compliance, which may be due to fibrotic and/or atherosclerotic changes. This observational study investigates imaging-pathologic correlates of cerebral artery 4D flow MRI in 20 initial brain donors (mean (SD) age at death 78.2 (10.3) years; 3.2 (1.4) years from MRI to autopsy) from the Wisconsin Alzheimer’s Disease Research Center who underwent antemortem imaging and postmortem assessment of cerebral artery and brain pathology to identify possible pathologic correlates of 4D flow MRI. Our results suggest that 4D flow MRI measures recapitulate expected hemodynamic and structural relationships across cerebral arteries, but also that measures like MRI cross-sectional area may reflect arterial fibrosis whereas mean blood flow may indicate downstream cerebrovascular disease, including white matter rarefaction and arteriolosclerosis. In contrast, associations were minimal with pulsatility index and cerebral artery or brain pathology across participants but were moderate across arterial segments. To our knowledge, this is the first study to investigate pathologic correlates of antemortem 4D flow MRI in cerebral arteries. These results provide preliminary insights regarding the pathologic processes contributing to cerebral artery hemodynamics measured with 4D flow MRI that will help inform interpretation of large-scale clinical aging and dementia studies utilizing this method. Future work with larger samples is needed to confirm these findings.
Archaeologies and Organologies: Toward an Alternative History of Early Synthetic Video and Image Processing Practices, 1939–1969
Authors: King Chris Jan 
Published: October 2024

Abstract
This article focuses on the early history of two related techniques used within artistic contexts: distorting preexisting television raster images and generating synthetic images through the application of external signals to cathode-ray tube deflection systems. Organology and media archaeological techniques are used to begin to trace an additional technical history of these complex visual instruments.
As Freely as Picasso: Nam June Paik, WGBH-TV, and the Video Synthesizer
Authors: Koh Helen 
Published: October 2024

Abstract
During an artist’s residency at WGBH-TV, Nam June Paik invented a new method of image production that created complex feedback, brilliant color, and nonstop mixing from multiple sources. The Paik-Abe Video Synthesizer allowed him to distort images and produce electronic disturbances that transformed the language, content, and geopolitics of television. This article highlights Paik’s transnationalism and the centrality of collaboration in his video projects.
Gamma frequency connectivity in frontostriatal networks associated with social preference is reduced with traumatic brain injury
Authors: Salimi Morteza , Tang Tianzhi , Nazari Milad , Mishra Jyoti , Afshar Houtan Totonchi , Koloski Miranda Francoeur , Ramanathan Dhakshin S. 
Published: October 2024

Abstract
Among the myriad of complications associated with traumatic brain injury (TBI), impairments in social behaviors and cognition have emerged as a significant area of concern. Animal models of social behavior are necessary to explore the underlying brain mechanisms contributing to chronic social impairments following brain injury. Here, we utilize large-scale brain recordings of local field potentials to identify neural signatures linked with social preference deficits following frontal brain injury. We used a controlled cortical impact model of TBI to create a severe bilateral injury centered on the prefrontal cortex. Behavior (social preference and locomotion) and brain activity (power and coherence) during a three-chamber social preference task were compared between sham and injured animals. Sham rats preferred to spend time with a social conspecific over an inanimate object. An analysis of local field oscillations showed that social preference was associated with a significant increase in coherence in gamma frequency band across widespread brain regions in these animals. Animals with a frontal TBI showed a significant reduction in this social preference, visiting an inanimate object more frequently and for more time. Reflecting these changes in social behavior, these animals also showed a significant reduction in gamma frequency (25–60 Hz) coherence associated with social preference.
Thalamocortical interactions reflecting the intensity of flicker light–induced visual hallucinatory phenomena
Authors: Amaya Ioanna A. , Nierhaus Till , Schmidt Timo T. 
Published: October 2024

Abstract
Aberrant thalamocortical connectivity occurs together with visual hallucinations in various pathologies and drug-induced states, highlighting the need to better understand how thalamocortical interactions may contribute to hallucinatory phenomena. Flicker light stimulation (FLS) at 10-Hz reliably and selectively induces transient visual hallucinations in healthy participants. Arrhythmic flicker elicits fewer hallucinatory effects while delivering equal amounts of visual stimulation, together facilitating a well-controlled experimental setup to investigate the neural correlates of visual hallucinations driven by flicker rhythmicity. Using rhythmic and arrhythmic FLS during fMRI scanning, we found that rhythmic FLS elicited stronger activation in higher order visual cortices compared with arrhythmic control. Consistently, we found that rhythmic flicker selectively increased connectivity between ventroanterior thalamic nuclei and higher order visual cortices, which was also positively associated with the subjective intensity of visual hallucinatory effects. As these thalamic and cortical areas do not receive primary visual inputs, it suggests that the thalamocortical connectivity changes relate to a higher order function of the thalamus, such as in the coordination of cortical activity. In sum, we present novel evidence for the role of specific thalamocortical interactions with ventroanterior nuclei within visual hallucinatory experiences. Importantly, this can inform future clinical research into the mechanistic underpinnings of pathologic hallucinations.
Promoting a Positive Shared Future through Transnational Chinese in Thailand: a Case Study of a Self-Styled Sino-Thai Folk Diplomat
Authors: Lee Kian Cheng 
Published: October 2024

Abstract
This research report argues that the promotion of a positive shared future for all humanity can be accomplished through dual-embedded transnational People’s Republic of China (PRC) Chinese social actors who are self-styled Sino-Thai folk diplomats making multiple contributions in countries both of origin and of residence. Conceptually, this research report remedies unilateral state-centric diplomacy, scarcity of intra-Asian Chinese migrant studies, the limited scope of non-state actors, dichotomous categorization of transnational Chinese, and an over-emphasis on exhibitive and pretentious unilateral exports in Chinese foreign policy. Through the research-based case study of a transnational Chinese residing in Bangkok, Thailand, this research report exemplifies the multiple folk contributions to both Thailand and China. As policy considerations, this research report proffers: (1) avoiding the generalization of Chinese transnationals in Southeast Asia; (2) appreciating the growing realm of social actors and their contributions; and (3) applying a sophisticated developmental perspective to domestic governance. Against rising protectionism, xenophobia, and precarious global challenges, this research report advocates a positive shared future for all humanity through the lens of Sino-Thai folk diplomacy.
Amid the Alien Corn: Capitalism and Animal Life
Authors: Soper Kate 
Published: October 2024

Abstract
This essay considers the multiple, and often conflicting, ways in which capitalism may be said to have impacted on animal experience. Capitalism has intensified a perennial division in human culture between instrumental and affective responses to animals. In their engagement with animals, left and Marxist critics of capitalism have either ignored animals or argued for naturalist and anti-humanist positions of a kind carried over into the contemporary post-humanist paradigm, with its emphasis on human-animal affinities and continuities. I, by contrast, put the case for grounding a more animal-friendly eco-politics in recognition of what is distinctive to human beings, both as agents of environmental crisis and as alone in a position to take action to counter it. In the process, I point to some ways to improve the experience of animals in a post-capitalist society and consider the problems they might encounter.