bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computerized cognitive training improves cognitive function in primary breast cancer survivors
Authors: Kleinknecht Karl R. , Bierend Mira , Keim Lisa-Maria , Bartels Frederik , Lampit Amit , Finke Carsten 
Published: September 2024

AbstractCancer-related cognitive impairment has a significant impact on the quality of life and perceived cognitive ability of breast cancer patients and frequently affects attention, working memory, and executive function. Several interventional approaches to treat these deficits have been studied, including web-based cognitive training, but methods and timing in relation to cancer treatment are heterogeneous. Only few interventions start early after primary breast cancer treatment, a time when many patients report the greatest impairments in quality of life and cognition. In this randomized controlled pilot study, 31 breast cancer survivors with subjective cognitive deficits and a mean post-treatment duration of 6.6 months (SD = 9.3) were assigned to either 14 weeks of a web-based cognitive training program (training group, n = 16) or a control group (n = 15). All patients underwent detailed neuropsychological assessment, evaluation of patient-reported outcomes (PROMs), and neurological examination before (baseline, T1) and after (follow-up, T2) the intervention. Longitudinal (T1 vs. T2) and cross-sectional (T2) cognitive performance was assessed for both groups. Overall cognitive impairment significantly improved in the training group following training (56% vs 25%; p = 0.03, Phi = 0.51), but not in the control group (73% vs. 73%; p = 1) in the longitudinal analysis (T1 vs. T2). Specifically, the training group showed statistically significant improvement of executive functions (p = 0.004, Phi = 0.32). No effects of training on subjective cognitive deficits or PROMs were observed. Comparing cross-sectional cognitive performance at follow-up (T2), the training group showed a significantly lower rate of cognitive impairment overall (p = 0.007, Phi = 0.48) and a better cognitive performance for executive function (p = 0.04, Phi = 0.32) compared to the control group. In this prospective pilot study, web-based cognitive training was efficacious in improving overall cognitive performance and executive function. Importantly, this study investigated a web-based cognitive training for the immediate post-treatment phase, when up to 75% of breast cancer patients experience cognitive decline. These results indicate that cognitive training may improve neuropsychological outcomes for patients with breast cancer.
Mosaic HIV-1 vaccine and SHIV challenge strain V2 loop sequence identity and protection in primates
Authors: Vanshylla Kanika , Tolboom Jeroen , Stephenson Kathryn E. , Feddes-de Boer Karin , Verwilligen Annemiek , Rosendahl Huber Sietske Karla , Rutten Lucy , Schuitemaker Hanneke , Zahn Roland C. , Barouch Dan H. , Wegmann Frank 
Published: September 2024

AbstractThe failure of human vaccine efficacy trials assessing a mosaic HIV-1 vaccine calls into question the translatability of preclinical SHIV challenge studies that demonstrated high efficacy of this vaccine in primates. Here we present a post hoc immune correlates analysis of HIV-1 Env peptide-binding antibody responses from the NHP13-19 study identifying the V2 loop as the principal correlate of protection in primates. Moreover, we found high V2 loop sequence identity between the Mos1 vaccine component and the SHIV challenge strain, while the vaccine showed considerably lower V2 identity to globally circulating HIV-1 sequences. Thus, the induction of immune responses against the V2 epitope, which had exceptional identity between the vaccine and challenge Env strains, may have contributed to the high protection in primates.
Large-scale analysis of CDH1 mutations defines a distinctive molecular subset with treatment implications in gastric cancer
Authors: Wang Jingyuan , Xiu Joanne , Battaglin Francesca , Arai Hiroyuki , Soni Shivani , Zhang Wu , Goldberg Richard M. , Philip Philip A. , Seeber Andreas , Hwang Jimmy J. , Shields Anthony F. , Marshall John L. , Astaturov Igor , Liu Tianshu , Lockhart A. Craig , Korn W. Michael , Shen Lin , Lenz Heinz-Josef 
Published: September 2024

AbstractAlthough histological and molecular classifications have been extensively studied for gastric cancer (GC), targeted therapies for GC remain limited. CDH1 mutations (MT) are characteristic of genomically stable GC and are associated with poor prognosis, but lack effective or targeted therapies. Here, we showed the overall mutation frequency of CDH1 was 9.7% (155 of 1596). CDH1-MT GC showed significantly lower rates of PD-L1 positivity (CPS score ≥1) than CDH1-wildtype (WT) GC (56.7% vs. 73.3%, p < 0.05). Compared to CDH1-WT GC, mutations of ARID1A, WRN, POT1, CDK12, and FANCC were significantly higher, while TP53 and APC were significantly lower in CDH1-MT GC (p < 0.05); The rates of KRAS and HER2 amplifications were significantly lower, while CRKL and IGF1R amplifications were significantly higher in CDH1-MT GC, compared to CDH1-WT GC (p < 0.05). Frequently altered genes in CDH1-MT GC were especially enriched in DNA damage repair and cell cycle checkpoint pathways. Inhibition of E-cadherin sensitized GC cell lines to PARP and Wee1 inhibitors by disrupting DNA damage repair pathway and cell cycle checkpoint. This is the largest study to investigate the distinct genomic landscape of CDH1-MT GC. Our data indicated GC patients with CDH1 mutations could potentially benefit from agents targeting PARP and Wee1.
Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases
Authors: Ludwig Megan L. , Moline David , Horrmann Alec , Boytim Ella , Larson Gabrianne , Arafa Ali T. , Sayeda Masooma , Lozada John R. , Bergom Hannah E. , Day Abderrahman , Dasaraju Sandhyarani , Dehm Scott M. , Murugan Paari , Hwang Justin , Drake Justin M. , Antonarakis Emmanuel S. 
Published: September 2024

AbstractMetastases to the brain are rare in prostate cancer. Here, we describe a patient with two treatment-emergent metastatic lesions, one to the brain with neuroendocrine prostate cancer (NEPC) histology and one to the dural membrane of adenocarcinoma histology. We performed genomic, transcriptomic, and proteomic characterization of these lesions and the primary tumor to investigate molecular features promoting these metastases. The two metastatic lesions had high genomic similarity, including TP53 mutation and PTEN deletion, with the most striking difference being the additional loss of RB1 in the NEPC lesion. Interestingly, the dural lesion expressed both androgen receptor and neuroendocrine markers, suggesting amphicrine carcinoma (AMPC). When analyzing pioneer transcription factors, the AMPC lesion exhibited elevated FOXA1 activity while the brain NEPC lesion showed elevated HOXC10, NFYB, and OTX2 expression suggesting novel roles in NEPC formation or brain tropism. Our results highlight the utility of performing multi-omic characterization, especially in rare cancer subtypes.
Overcoming biases of individual level shopping history data in health research
Authors: Skatova Anya 
Published: September 2024

AbstractNovel sources of population data, especially administrative and medical records, as well as the digital footprints generated through interactions with online services, present a considerable opportunity for advancing health research and policymaking. An illustrative example is shopping history records that can illuminate aspects of population health by scrutinizing extensive sets of everyday choices made in the real world. However, like any dataset, these sources possess specific limitations, including sampling biases, validity issues, and measurement errors. To enhance the applicability and potential of shopping data in health research, we advocate for the integration of individual-level shopping data with external datasets containing rich repositories of longitudinal population cohort studies. This strategic approach holds the promise of devising innovative methodologies to address inherent data limitations and biases. By meticulously documenting biases, establishing validated associations, and discerning patterns within these amalgamated records, researchers can extrapolate their findings to encompass population-wide datasets derived from national supermarket chain. The validation and linkage of population health data with real-world choices pertaining to food, beverages, and over-the-counter medications, such as pain relief, present a significant opportunity to comprehend the impact of these choices and behavioural patterns associated with them on public health.
STAT1 as a tool for non-invasive monitoring of NK cell activation in cancer
Authors: Min Jin Young , Kim Hye Min , Lee Hyunseung , Cho Mi Young , Park Hye Sun , Lee Sang-Yeop , Park Min Sung , Ha Sang Keun , Kim Donghwan , Jeong Hye Gwang , Kim Tae-Don , Hong Kwan Soo , Han Eun Hee 
Published: September 2024

AbstractNatural killer (NK) cells play a crucial role in immunotherapy for cancer due to their natural ability to target and destroy cancer cells. However, current methods to visualize NK cells’ activity against tumors in live organisms are limited. We introduce an imaging method that non-invasively tracks NK cell activation by cancer cells through the STAT1 protein. To achieve this, we modified NK cells to include a specific genetic sequence that binds to STAT1 when activated. These engineered NK cells (GAS-NK) demonstrate their functionality through various biological tests and analysis. Observations of changes in cancer environments and patient-derived cancer organoid models further confirm the effectiveness of this approach. Our method provides a way to monitor NK cell activity, which could improve the prediction and effectiveness of NK cell-based cancer therapies, contributing to advances in cancer treatment.
Gate tunable edge magnetoplasmon resonators
Authors: Frigerio Elric , Rebora Giacomo , Ruelle Mélanie , Souquet-Basiège Hubert , Jin Yong , Gennser Ulf , Cavanna Antonella , Plaçais Bernard , Baudin Emmanuel , Berroir Jean-Marc , Safi Inès , Degiovanni Pascal , Fève Gwendal , Ménard Gerbold C. 
Published: September 2024

AbstractQuantum Hall systems are platforms of choice to study topological properties of condensed matter systems and anyonic exchange statistics. In this work we have developed a tunable radiofrequency edge magnetoplasmonic resonator controlled by both the magnetic field and a set of electrostatic gates, meant to serve as a versatile platform for future interferometric devices designed to evidence non-abelian anyons. In our device, gates allow us to change both the size of the resonant cavity and the electronic density of the two-dimensional electron gas. We show that we can continuously control the frequency response of our resonator, making it possible to develop an edge magnetoplasmon interferometer. As we reach smaller sizes of our resonator, finite size effects caused by the measurement probes manifest. In the future, such device will be a valuable tool to investigate the properties of non-abelian anyons in the fractional quantum Hall regime.
Correction of a widespread bias in pooled chemical genomics screens improves their interpretability
Authors: Kim Lili M , Todor Horia , Gross Carol A 
Published: September 2024

AbstractChemical genomics is a powerful and increasingly accessible technique to probe gene function, gene–gene interactions, and antibiotic synergies and antagonisms. Indeed, multiple large-scale pooled datasets in diverse organisms have been published. Here, we identify an artifact arising from uncorrected differences in the number of cell doublings between experiments within such datasets. We demonstrate that this artifact is widespread, show how it causes spurious gene–gene and drug–drug correlations, and present a simple but effective post hoc method for removing its effects. Using several published datasets, we demonstrate that this correction removes spurious correlations between genes and conditions, improving data interpretability and revealing new biological insights. Finally, we determine experimental factors that predispose a dataset for this artifact and suggest a set of experimental and computational guidelines for performing pooled chemical genomics experiments that will maximize the potential of this powerful technique.
Against linkage: A novel generative face anonymization framework with style diversification
Authors: Zhu Mingcheng , He Peisong , Zhang Yuhao , Li Jinghan , Qiu Yupeng 
Published: September 2024

AbstractWith the advent of the digital era, millions of facial images are shared online daily, posing severe privacy threats. Generative face anonymization (GFA) methods generate virtual faces to conceal original identities, protecting sensitive information while preserving utility. However, deep learning based user identity linkage (UIL) methods can link similar faces to the same identity and leverage the linked profiles for malicious purposes, including localization and behaviour prediction. These UIL methods pose a significant challenge to the diversity of virtual faces, a challenge that existing GFA methods have not adequately addressed. To address this research gap, we propose Style Diversification‐based Generative Face Anonymization (SD‐GFA), a framework that generates virtual faces with diverse identities and high visual quality. SD‐GFA features an equalized control module to balance input faces and user‐specified keys, a face generation module with a re‐connection strategy for high‐quality synthesis, and a maximum probability simulation module to enhance diversity. Our experiments demonstrate that SD‐GFA effectively mitigates linkage risk by improving the diversity of virtual faces, while also enhancing their utility and visual quality. This study provides a robust solution to enhance the security of anonymized faces shared on the internet.
Ambulante Durchführung rhinochirurgischer Operationen unter Berücksichtigung des Einsatzes von Nasentamponaden
Authors: Weber Rainer K. , Deitmer Thomas , Löhler Jan , Aletsee Christoph , Baumann Ingo , Betz Christian , Beule Achim , Böscke Robert , Dietz Andreas , Harnischmacher Vanessa , Haubner Frank , Heppt Werner , Hoffmann Anna Sophie , Hoffmann Thomas K. , Hosemann Werner , Kuehnel Thomas , Laudien Martin , Olzowy Bernhard , Seibert Kim-Victoria , Sommer Fabian , Verse Thomas , Wiegand Susanne , Hildenbrand Tanja 
Published: September 2024

Zusammenfassung
Hintergrund Die Ambulantisierung rhinochirurgischer Eingriffe wird derzeit intensiv diskutiert und insbesondere von politischer Seite stark propagiert. Viele Fragen zur Stratifizierung in ambulante oder stationäre Durchführung sind unklar. Insbesondere das Vorgehen bei Anwendung von Nasentamponaden ist bisher nicht ausreichend diskutiert.
Material und Methoden Entwicklung einer Checkliste zur ambulanten Durchführung rhinochirurgischer Operationen unter Berücksichtigung der aktuellen Literatur.
Ergebnisse und Schlussfolgerungen Nach umfassender Auswertung der Literatur und Analyse von Risikofaktoren wird eine Liste von stationär durchzuführenden rhinochirurgischen Operationen definiert. Es wird eine Checkliste für die ambulante oder stationäre Durchführung rhinochirurgischer Operationen vorgelegt, die soziale, allgemeine medizinische und spezifische operationsbedingte Gründe berücksichtigt und hierbei die Anwendung von Nasentamponaden einschließt. Sie wird ergänzt durch eine Checkliste, anhand derer Kriterien die Entlassungsfähigkeit von Patienten nach einer ambulant geplanten rhinochirurgischen Operation bewertet wird.
A Review of Third-Trimester Complications in Pregnancies Complicated by Diabetes Mellitus
Authors: Welsey Shaun R. , Day Jessica , Sullivan Scott , Crimmins Sarah D. 
Published: September 2024

Pregnancies affected by both pregestational and gestational diabetes mellitus carry an increased risk of adverse maternal and neonatal outcomes. While the risks associated with diabetes in pregnancy have been well documented and span across all trimesters, maternal and neonatal morbidity have been associated with select third-trimester complications. Further, modifiable risk factors have been identified that can help improve pregnancy outcomes. This review aims to examine the relationship between select third-trimester complications (large for gestational age, intrauterine fetal demise, hypertensive disorders of pregnancy, preterm birth, perineal lacerations, shoulder dystocia, and cesarean delivery) and the aforementioned modifiable risk factors, specifically glycemic control, blood pressure control, and gestational weight gain. It also highlights how early optimization of these modifiable risk factors can reduce adverse maternal, fetal, and neonatal outcomes.
Key Points
Effect of Low Dose Glucocorticoid Inhalation on Bronchopulmonary
Dysplasia in Premature Infants
Authors: Li Xiaohua , Liu Heng 
Published: September 2024

AbstractThe aim of the study was to explore the effect of low dose glucocorticoid on
bronchopulmonary dysplasia in premature infants, to provide new ideas for
clinical prevention and cure of bronchopulmonary dysplasia in premature infants.
The 144 cases of premature infants were divided into 72 each: control group and
experimental group. Control group received routine clinical prevention and cure,
while experimental group was received low dose glucocorticoid on the basis of
control group. The serum interleukin-10 (IL-10) , interleukin-8 (IL-8), and
transforming growth factor-1 (TGF-β1) before and after treatment were compared
between two groups. The incidence and severity of bronchopulmonary dysplasia was
compared between two groups. The mechanical ventilation time, oxygen inhalation
time and hospitalization time in two groups were recorded, and the body mass,
head circumference and body length at 30 days after birth were assessed in both
groups. After treatment, the serum IL-10 level in experimental group was
increased and IL-8, TGF-β1 levels were decreased compared with control group (p
<0.05). The incidence rate of bronchopulmonary dysplasia in experimental
group was 13.89% and the disease severity in experimental group was
significantly reduced (p<0.05). Both groups exhibited no notable adverse
reactions (p>0.05). Low-dose glucocorticoids have a significant preventive
and therapeutic effect on bronchopulmonary dysplasia in preterm infants, and
have a high safety, showing high clinical application value for bronchopulmonary
dysplasia in preterm infants.
Ethylene Glycol Mediated, Catalyst-Free Synthesis of Bis(pyrazolo) pyridines and Their Photophysical Studies
Authors: Ramesh Subburethinam , Shanthi Markabandhu , Janani Ravichandran , Puhazhendhi Arulmozhi , Shankar Bhaskaran , Sivalingam Soumya 
Published: September 2024

AbstractA new hetero-annulation procedure for the selective synthesis of bis(pyrazolo)-fused pyridines using pyrazole-5-amines and aryl glyoxal monohydrate is described. This distinct hetero-annulation, carried out under catalyst-free conditions with ethylene glycol as the medium, illustrates a domino reaction that involves the formation of two C–C bonds and one C–N bond. The photophysical properties of the synthesized derivatives were briefly analyzed. The emission spectra of the derivatives exhibited distinct charge transfer peaks, which depends on the structure of the derivatives. The green metrics calculation for the protocol to quantify the waste, reaction efficiency, and sustainability was evaluated.
Visible-Light Organophotoredox-Catalyzed Phosphonoalkylation of Alkenes via Deaminative Three-Component Radical–Radical Coupling
Authors: Jana Ranjan , Das Subhodeep , Banerjee Amit , Das Pritha 
Published: September 2024

AbstractHere, we have reported a visible-light-mediated organic photoredox-catalyzed difunctionalization of vinyl arenes via radical–radical coupling. A stabilized benzylic radical at the α-position is generated via the regioselective addition of phosphonyl radical at the β-position of the styrene. Subsequently, benzyl or allyl radical, generated via the deaminative pathway from the Katritzky salt, combines with the α-radical of the styrene to furnish the functionalised C–P and C–C bonds in a single reaction.
Transition-Metal-Mediated Radiohalogenation using Aryl Boron Reagents
Authors: Sutherland Andrew , Burianova Valeria K. , McErlain Holly 
Published: September 2024

AbstractBiomolecules labeled with radioisotopes of iodine and fluorine play a major role in science and medicine, with a range of applications including molecular imaging of disease, as radiopharmaceuticals for therapy and as tools for drug discovery. Due to the relative stability of Csp2–halogen bonds, radioiodine and radiofluorine labels are commonly incorporated into tracers via arene substitution. The wide availability of aryl boron reagents has led to their use for the development of radioiodination and radiofluorination methods, particularly using transition-metal complexes for accelerated reactions. Here, we review the range of transition-metal-mediated methods that have been developed for radiohalogenation of aryl boron compounds. Applications of these transformations for the preparation of molecular imaging agents and the use of new technologies to advance automated synthesis or high-throughput discovery are also described.1	Introduction2	Radioiodination Using Aryl Boron Reagents2.1	Applications of Copper-Mediated Radioiodination Reactions3	Radiofluorination Using Aryl Boron Reagents3.1	Radiofluorination Using Palladium, Nickel and Silver Complexes3.2	Radiofluorination Using Copper Complexes3.3	Applications of Copper-Mediated Radiofluorination Reactions3.4	New Technology for Copper-Mediated Radiofluorination Reactions4	Conclusions
Management of Compound Depressed Fractures over Venous Sinuses
Authors: Elbaroody Mohammad , Marei Ahmed A. , Sawy Karim Fathy , Mahmoud Alaa Eldin , Amin Mark Charl , Elkatatny Amr A.M. , badea Hazem Abd Al 
Published: September 2024

Abstract
Objective The aim of this study was to report our experience in the surgical treatment of compound depressed fractures over the venous sinuses with special highlights on the prediction and dealing with intraoperative sinus injury.
Materials and Methods We conducted a retrospective review of all patients who underwent surgery for compound depressed fractures overlying the dural venous sinuses in our hospital between January 2019 and December 2021.
Results A total of 34 patients were included in our study. The mean age of the patients was 19.85 years, most of our patients were males 27 (79.4%), and isolated head trauma was the most common mode of trauma (76.5%). The superior sagittal sinus (SSS) was distinguished as the most commonly involved venous sinus below the fractures in 28 patients (82.4%). An intraoperative tear in the sinus was found in 17 patients (50%), which was easily controlled with different methods. In two patients who had a severe head injury with a Glasgow Coma Scale (GCS) score of ≤8 associated with a fissure fracture crossing the sinus, there was a complete tear of the sinus followed by massive bleeding, which required sinus ligation. We lost both of them in following days.
Conclusion In experienced tertiary neurotrauma centers, compound depressed fractures over the venous sinuses should be surgically elevated in most cases, taking into consideration that bleeding from the sinus can be controlled in most cases, and complete tear of the sinus with massive bleeding is the least scenario faced in reality and is usually associated with a severe head injury. If expert opinion favors the conservative approach, then close follow-up for months is recommended due to the high possibility of sinus thrombosis and intracranial hypertension, especially in children.