bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of 1 week of repeated ischaemic leg preconditioning on simulated Keirin cycling performance: a randomised trial
Authors: Lindsay Angus , Petersen Carl , Blackwell Gavin , Ferguson Hamish , Parker Greg , Steyn Nina , Gieseg Steven P 
Published: June 2017

BackgroundCoaches continually seek new ways of doing things and also refine existing techniques to improve sporting performance. Coaches are currently experimenting using ischaemic preconditioning (IPC) over consecutive days in the hope of improving competitive performances.AimsFirst, to quantify the physiological impact of 1 week of IPC on simulated Keirin cycling performance. Second, to investigate if biochemical stress markers are affected over the treatment period.MethodsUsing a randomised, sham-controlled design, 18 active adults undertook seven consecutive days of IPC treatment (4×5 min occlusion/reperfusion) applied to each leg at either 220 mm Hg (treatment, n=9) or 20 mm Hg (sham, n=9). Urinary measures of inflammation, oxidative stress and indirect nitric oxide synthesis were undertaken daily. A simulated Keirin cycling competition (4×30 s Wingate tests) was performed on day 10, with baseline and postintervention cycling VO2max (days 1, 11 and 18) and 30 s Wingate tests (day 2) undertaken for comparison.ResultsThe treatment group had enhanced mean cycling power (3.4%), while neopterin and biopterin in conjunction with total neopterin were significantly lower (p<0.05) and total biopterin significantly greater (p<0.05) during the simulated Keirin. Aerobic fitness measures significantly improved from baseline to postintervention (VO2peak: 12.8% ↑, maximal aerobic power: 18.5% ↑).ConclusionsSeven consecutive days of IPC improved aerobic and anaerobic capacity measures, with modulations in oxidative stress, immune system activation and nitric oxide/catecholamine synthesis.
Temperature compensation effects of TiO2 on Ca[(Li1/3Nb2/3)0.8Sn0.2]O3−δ microwave dielectric ceramic
Authors: Hu Mingzhe , Wei Huanghe , Xiao Lihua , Zhang Kesheng , Hao Yongde 
Published: June 2017

The crystal structure and dielectric properties of TiO2-modified Ca[(Li[Formula: see text]Nb[Formula: see text])[Formula: see text]Sn[Formula: see text]]O[Formula: see text] microwave ceramics are investigated in the present paper. The crystal structure is probed by XRD patterns and their Rietveld refinement, results show that a single perovskite phase is formed in TiO2-modified Ca[(Li[Formula: see text]Nb[Formula: see text])[Formula: see text]Sn[Formula: see text]]O[Formula: see text] ceramics with the crystal structure belonging to the orthorhombic Pbnm 62 space group. Raman spectra results indicate that the [Formula: see text]-site order–disorder structure transition is a key point to the dielectric loss of TiO2-modified Ca[(Li[Formula: see text]Nb[Formula: see text])[Formula: see text]Sn[Formula: see text]]O[Formula: see text] ceramics at microwave frequencies. After properly modified by TiO2, the large negative temperature coefficient of Ca[(Li[Formula: see text]Nb[Formula: see text])[Formula: see text]Sn[Formula: see text]]O[Formula: see text] ceramic can be compensated and the optimal microwave dielectric properties can reach [Formula: see text] = 25.66, [Formula: see text] = 18,894 GHz and TCF = −6.3 ppm/[Formula: see text]C when sintered at 1170[Formula: see text]C for 2.5 h, which manifests itself for potential use in microwave dielectric devices for modern wireless communication.
Regional distribution and controls on the development of post-rift turbidite systems: insights from the Paleocene of the eastern North Viking Graben, offshore Norway
Authors: Dmitrieva Evelina , Jackson Christopher A.-L. , Huuse Mads , Kane Ian A. 
Published: May 2017

Abstract
Paleocene deep-water deposits of the Norwegian sector of the North Sea Basin are prospective for oil and gas, although little is known about their sedimentology and distribution, or the controls on their stratigraphic evolution. To help unlock the potential of this poorly explored interval, we integrate 3D seismic reflection, well logs and core data from the eastern North Viking Graben, offshore Norway. We show that thick (up to 80 m), high net to gross (N:G) (up to 90%), sandstone-rich channel-fills and sheet-like, likely lobe deposits occur on the slope–proximal basin floor, forming part of an aerially extensive fan system. Sediment dispersal and the resultant stratigraphic architecture are controlled by slope morphology. Bypass occurred on the northern, passive margin-type slope; whereas, in the south, sediment gravity currents were deflected around, and deep-water sandstones onlap and pinch-out onto an exposed rift-related fault block that generated intra-basin bathymetric relief. Pinchout of deep-water sandstone into mudstone suggests that future exploration should focus on identifying subtle stratigraphic traps on fault block flanks or at the fan fringe. This trapping style contrasts with that encountered in the UK sector of the Northern North Sea, where most Paleocene fields and discoveries are in structural traps related to the flow of Zechstein Supergroup salt.
Tamoxifen Acceptance and Adherence among Patients with Ductal Carcinoma In Situ (DCIS) Treated in a Multidisciplinary Setting
Authors: Karavites Lindsey C. , Kane Anna K. , Zaveri Shruti , Xu Yanfei , Helenowski Irene , Hansen Nora , Bethke Kevin P. , Rasmussen-Torvik Laura J. , Khan Seema A. 
Published: May 2017

Abstract
Tamoxifen and other endocrine agents have proven benefits for women with ductal carcinoma in situ (DCIS), but low patient acceptance is widely reported. We examined factors associated with tamoxifen acceptance and adherence among DCIS patients who received a recommendation for therapy in a multidisciplinary setting. Using our institutional database, we identified women diagnosed with DCIS, 1998 to 2009, who were offered tamoxifen. We recorded data on demographics, tumor and therapy variables, tamoxifen acceptance, and adherence to therapy for ≥4 years. Univariable and multivariable analyses were conducted using logistic regression to identify factors specific to each group that were related to acceptance and adherence. A total of 555 eligible women identified, of whom 369 were offered tamoxifen; 298 (81%) accepted, among whom 214 (72%) were adherent, 59 of 298 (20%) were nonadherent, and for 25 (8%), adherence was undetermined. After stepwise elimination in adjusted logistic regression models, acceptance of breast radiotherapy was associated with acceptance of tamoxifen [OR, 2.22; 95% confidence interval (CI), 1.26–3.90; P &lt; 0.01], as was a medical oncology consultation (OR, 1.76; 95% CI, 0.99–3.15; P = 0.05). Insured patients were more likely to adhere to tamoxifen (OR, 6.03; 95% CI, 2.60–13.98; P &lt; 0.01). The majority of nonadherent women (n = 38/56, 68%) discontinued the drug during the first year of treatment with 48 (86%) citing adverse effect(s) as the reason. In a multidisciplinary, tertiary care setting, we observed relatively high rates of acceptance and adherence of tamoxifen. Acceptance of tamoxifen and radiotherapy were associated, and adherence was influenced by insurance status.
Key Message: Tamoxifen acceptance and adherence following resection of DCIS of the breast is related to acceptance of radiotherapy and may be improved by confirmation of the recommendation by a medical oncologist. Despite the low cost of tamoxifen, adherence to therapy is significantly impacted by lack of insurance; those who discontinue therapy report adverse effects as a major reason. Cancer Prev Res; 10(7); 389–97. ©2017 AACR.
Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology Keystone Symposia Meeting Summary
Authors: Gubin Matthew M. 
Published: June 2017

Abstract
The Keystone Symposia conference on Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology was held at the Fairmont Chateau in Whistler, British Columbia, Canada, on March 19–23, 2017. The conference brought together a sold-out audience of 654 scientists, clinicians, and others from both academia and industry to discuss the latest developments in cancer immunology and immunotherapy. This meeting report summarizes the main themes that emerged during the four-day conference. Cancer Immunol Res; 5(6); 434–8. ©2017 AACR.
New records of harvestmen (Arachnida, Opiliones) from Minnesota, USA
Authors: SHOEMAKER A. KENJI , BURNS MERCEDES , BOYER SARAH L. 
Published: June 2017

Harvestmen (Opiliones) are a diverse order of arachnids composed of more than 6,600 described species which together span an almost global distribution. Although these animals may occur in extremely high abundance in both pristine and disturbed habitats, much of harvestman diversity remains undescribed, undocumented, and/or in need of taxonomic attention. In the current study, we focus on the harvestman diversity of the state of Minnesota, USA, where a lack of local expertise and effort has left the species richness of the state largely undocumented. We document two genera and seven species previously unrecorded in the state.—Leiobunum aldrichi, L. calcar, L. flavum, L. politum, L. ventricosum, L. vittatum, and Odiellus pictus.
Precipitation Characteristics in West and East Africa from Satellite and in Situ Observations
Authors: Dezfuli Amin K. , Ichoku Charles M. , Mohr Karen I. , Huffman George J. 
Published: June 2017

Abstract
Using in situ data, three precipitation classes are identified for rainy seasons of West and East Africa: weak convective rainfall (WCR), strong convective rainfall (SCR), and mesoscale convective systems (MCSs). Nearly 75% of the total seasonal precipitation is produced by the SCR and MCSs, even though they represent only 8% of the rain events. Rain events in East Africa tend to have a longer duration and lower intensity than in West Africa, reflecting different characteristics of the SCR and MCS events in these two regions. Surface heating seems to be the primary convection trigger for the SCR, particularly in East Africa, whereas the WCR requires a dynamical trigger such as low-level convergence. The data are used to evaluate the performance of the recently launched Integrated Multisatellite Retrievals for Global Precipitation Measurement (IMERG) project. The IMERG-based precipitation shows significant improvement over its predecessor, the Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA), particularly in capturing the MCSs, due to its improved temporal resolution.
Self-Reported Versus Accelerometer-Assessed Daily Physical Activity in Childhood Obesity Treatment
Authors: Schnurr Theresia M. , Bech Bianca , Nielsen Tenna R. H. , Andersen Ida G. , Hjorth Mads F. , Aadahl Mette , Fonvig Cilius E. , Hansen Torben , Holm Jens-Christian 
Published: May 2017

We investigated the relationship between interview-based subjective ratings of physical activity (PA) engagement and accelerometer-assessed objectively measured PA in children and adolescents with overweight or obesity. A total of 92 children and adolescents (40 males, 52 females) with BMI ≥ 90th percentile for sex and age, aged 5–17 years had valid GT3X + accelerometer-assessed PA and interview-assessed self-reported information on PA engagement at the time of enrollment in a multidisciplinary outpatient tertiary treatment for childhood obesity. Accelerometer-derived mean overall PA and time spent in moderate to vigorous physical intensity were generated, applying cut-offs based on Vector Magnitude settings as defined by Romanzini et al. (2014), and a physical activity score (PAS) based on self-reported data. Overall, a higher self-reported PAS was correlated with higher accelerometer-assessed daily total PA levels ( r = 0.34, p < .01) and children who reported a high PAS were more physically active compared with children who reported a low PAS. There was a fair level of agreement between self-reported PAS and accelerometer-assessed PA (Kappa agreement = 0.23; 95% CI = [0.03, 0.43]; p = .01). PAS, derived from self-report, may be a useful instrument for evaluating PA at a group level among children and adolescents enrolled in multidisciplinary obesity treatment.
Potential for Interfraction Motion to Increase Esophageal Toxicity in Lung SBRT
Authors: Pham Anthony Hoai-Nam , Yorke Ellen , Rimner Andreas , Wu Abraham Jing-Ching 
Published: June 2017

Purpose: To characterize the effect of the relative motion of esophagus and tumor on radiation doses to the esophagus in patients treated with stereotactic body radiation therapy for central lung tumors. Methods and Materials: Fifty fractions of stereotactic body radiation therapy in 10 patients with lung tumors within 2.5 cm of the esophagus were reviewed. The esophagus was delineated on each treatment’s cone-beam computed tomography scan and compared to its position on the planning scan. Dose–volume histograms were calculated using the original treatment beams to determine the actual dose delivered to the esophagus for each fraction of stereotactic body radiation therapy. Results: Median interfraction right–left shift of the esophagus was 0.9 mm (range, −5.4 to 3.3 mm) toward the left. Median interfraction anteroposterior shift was 0.7 mm (range, −3.7 to 11.5 mm) posteriorly. The median percentage increase in dose to 1 cm3, dose to 3.5 cm3, and dose to 5 cm3 was 1.7%, 5.6%, and 6.6%, respectively. Two cases of significant late esophageal toxicity were observed, with change in esophageal position relative to the planning target volume resulting in significantly higher D5cc values than anticipated. Conclusion: Interfraction shifts between the internal target volume and esophagus can lead to unanticipated increases in the volume of esophagus receiving high doses when treating central lung tumors with stereotactic body radiation therapy. Certain practical steps, such as considering deep breath hold for internal target volume reduction, using a planning risk volume for esophagus, and carefully visualizing and considering esophageal position at the time of stereotactic body radiation therapy, can be taken to minimize unanticipated dose increases that could cause unexpected esophageal toxicity.
Irreversible Electroporation Ablation of an Unresectable Fibrous Sarcoma With 2 Electrodes: A Case Report
Authors: Qin Zilin , Zeng Jianying , Liu Guifeng , Long Xinan , Fang Gang , Li Zhonghai , Xu Kecheng , Niu Lizhi 
Published: May 2017

Purpose: To explore the safety and efficacy of irreversible electroporation ablation in unresectable fibrous sarcoma with 2 electrodes. Methods: A 74-year-old woman with unresectable retroperitoneal malignant fibrous sarcoma was treated with percutaneous irreversible electroporation. Four ablations were performed on the mass, which measured 7.3 × 7.0 × 7.5 cm, with 2 electrodes. Results: A contrast-enhanced computed tomography scan 2 months postoperatively showed that the tumor had reduced to 5.1 × 4.0 × 5.2 cm, without obvious enhancement. Any adverse reactions were evaluated as level 1. Conclusion: In the short term, the treatment with 2 electrodes for fibrous sarcoma appears to be safe and effective.
Predictors of Adamkiewicz artery and anterior spinal artery detection through computerized tomographic angiography
Authors: Amato Alexandre Campos Moraes , Parga Filho Jose Rodrigues , Stolf Noedir Antonio Groppo 
Published: June 2017

Background: The detection of the Adamkiewicz artery and the anterior spinal artery has been associated with the ability to prevent adverse spinal cord outcomes after aortic surgical procedures. Yet, to our knowledge, no previous studies have attempted to use modern predictive models to identify the most important variables in determining artery detectability. Aims: To develop a model to predict the odds of visualizing the Adamkiewicz artery or anterior spinal artery in patients undergoing computerized tomographic angiography. Methods: We conducted a prospective, cross-sectional study. Outcomes of interest were the non-detection of the Adamkiewicz artery and anterior spinal artery, and their corresponding level of origin. Axial images were inspected in high definition in search of two dense spots characterizing the Adamkiewicz artery and anterior spinal artery. A multiplanar three-dimensional reconstruction was then performed using the OsiriX® software. Results: A total of 110 participants were part of this analysis. When evaluating risks for the Adamkiewicz artery being undetectable, significant factors could be classified into three broad categories: risk factors for arterial disease, established arterial disease, and obesity. Factors in the former category included metabolic syndrome, hypertension, and smoking status, while factors in the arterial disease included descending aortic aneurysm, mural thrombi, aortic aneurysm without a dissection, and aortic disease in general. In relation to anterior spinal artery not being detectable, significant risk factors included hypertension, smoking status, and metabolic syndrome, while those associated with arterial disease involved aortic disease and arterial thrombi. When evaluating the importance of individual clinical factors, the presence of higher body mass index was the single most important risk factor. Conclusion: Arterial disease, established arterial disease, and increased body mass index are risk factors in the detection of Adamkiewicz artery and anterior spinal artery. Specific diagnostic protocols should be in place for patients with these underlying conditions, thus enhancing the likelihood of detection when the Adamkiewicz artery is indeed present.
Concurrent BRAF and PTEN mutations in melanoma of unknown origin presenting as a breast mass
Authors: Agosto-Arroyo Emmanuel , Rosa Marilin , Chau Alec , Khazai Laila 
Published: May 2017

Background: Metastases represent a small percentage of the malignancies affecting the breast, and only 5% of melanomas originate from non-cutaneous sites. Multiple genetic aberrations have been associated with the development of melanocytic lesions, including BRAF V600E mutation. Mutations in PTEN gene have also been related to the pathogenesis of multiple malignancies. Purpose/Method: This is the case of a 28-year-old female who presented with a tender, palpable mass in the upper outer quadrant of the right breast. Ultrasound showed a 1-cm solid mass, initially diagnosed as invasive ductal carcinoma on biopsy. During pre-operative workup, a second mass was identified and biopsied. Immunohistochemical stains performed on the second mass biopsy demonstrated that the neoplastic cells were positive for cytokeratin AE1/3, pan-melanoma, tyrosinase, and SOX-10 and negative for CK7, CAM5.2, and GATA-3. Subsequent workup showed widespread metastatic disease involving the liver, lungs, bones, and brain. The brain metastasis tested positive for BRAF p.V600E and PTEN p.R130Efs*4 mutations. Thorough skin and eye examination did not reveal a primary melanoma. Conclusion: Only few reports have been published of melanoma presenting as a breast mass. This is an interesting case due to the clinical presentation, diagnostic challenges, and genetic mutations profile.
Lymph node transfer for refractory infectious sites caused by trauma
Authors: Mihara Makoto , Hara Hisako , Kikuchi Kazuki 
Published: June 2017

Objective: In this report, we placed focus on the immunological function of lymph nodes and performed lymph node transfer via a free flap to a site of refractory infection. Case and Results: Case 1 describes a 34-year-old male suffering from compound fractures with severe crush injuries and burns in the right ankle joint. A 20 × 15 cm skin defect was observed around the right malleolus medialis, along with denuded tendons with bacterial infection. After conservative treatment, we transferred a lymph-node-containing free superficial circumflex iliac artery perforator flap to the region, with minimum debridement. No recurrence of wound infection appeared. Case 2 describes a 73-year-old male patient suffering from extensive contused wound in the right crus. Despite conservative treatment, the tibia gradually became denuded with computed tomography and magnetic resonance imaging revealing degeneration of the tibial cortex. We performed a free superficial circumflex iliac artery perforator flap containing lymph nodes to the chronic infection area. The wound area healed successfully. Conclusion: In conclusion, lymph node transfer has a potential of treatment infection sites.
A Levering Technique Using Small Parallel Rods for Open Reduction of High-Grade Thoracolumbar Dislocation
Authors: Hadgaonkar Shailesh , Shah Kunal , Khurjekar Ketan , Krishnan Vibhu , Shyam Ashok , Sancheti Parag 
Published: May 2017

Study Design: Technical report. Objective: Dorsolumbar vertebral dislocations, with or without associated fractures, occur secondary to very high velocity trauma. The reduction procedures and techniques, which may be adopted in these situations, have been multifariously discussed in the literature. Our objective was to assess the outcome of a novel reduction maneuver, using parallel rods which we have employed in reduction of high-grade thoracolumbar fractures to achieve precise sagittal balance as well as accurate vertebral alignment with minimal soft tissue damage. Methods: The study included a total of 11 cases of thoracolumbar dislocations, who had presented to our emergency spine services following high-velocity trauma. After appropriate systemic stabilization and necessary investigations, all patients were surgically treated using the described technique. Results: There were no surgical complications at 2-year follow-up. Radiographs showed good reduction and maintained sagittal balance. Conclusion: We believe that this technique is an excellent means of achieving safer, easier, and accurate reduction for restoration of sagittal/coronal balance and alignment in high-grade thoracolumbar dislocations. It is easily reproducible and predictable.
Outcome & Survival Analysis of Conventional Measured Resection, Neutral Alignment Attune TKA vs CAS Anatomic Tibia, Balanced Femur, Constitutional Alignment Attune TKA
Authors: Clatworthy Mark 
Published: May 2017

Objectives: Arthroplasty knee surgeons have traditionally performed a measured resection technique with a neutral mechanical axis. We have recently developed a new total knee arthroplasty technique whereby the tibia is cut anatomically and the femoral component position is determined using a balanced approach utilizing a computer assisted ligament tension device with aim of restoring constitutional alignment. This study compares the Oxford scores and survival of these two techniques for Attune TKA’s. Method: The New Zealand Joint Registry has requested Oxford Knee Scores at six months on all Attune Total Knee Replacements performed. 1088 scores have been returned. 716 have been performed using a conventional measured resection technique aiming for a neutral mechanical axis. 362 have been performed using the CAS anatomic tibia, balanced femur (ATBF) technique aiming for constitutional alignment. Oxford scores are compared alone and with a multivariate analysis including age, sex, surgeon level, fixed vs mobile, public vs private, operative time and cruciate retaining vs cruciate substituting Results: Mean Oxford Conventional TKA univariate Oxford Score is 38.1 Mean Oxford CAS ATBF TKA univariate Oxford Score is 40.7 p=<0.001 Mean Oxford Conventional TKA multivariate Oxford Score is 36.9 Mean Oxford CAS ATBF TKA multivariate Oxford Score is 39.1 p=<0.001 The CAS ATBF had 10% less poor and fair scores and 15% more excellent scores Non infection conventional TKA has 0.71 failures per 100 component years Non infection CAS ATBF TKA has 0.25 failures per 100 component years. Conclusion: The CAS assisted anatomic tibia balanced femur TKA has a significantly higher Oxford score with a three times lower non infection failure rate at three years