bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subventricular zone involvement in Glioblastoma – A proteomic evaluation and clinicoradiological correlation
Authors: Gollapalli Kishore , Ghantasala Saicharan , Kumar Sachendra , Srivastava Rajneesh , Rapole Srikanth , Moiyadi Aliasgar , Epari Sridhar , Srivastava Sanjeeva 
Published: April 2017

AbstractGlioblastoma multiforme (GBM), the most malignant of all gliomas is characterized by a high degree of heterogeneity and poor response to treatment. The sub-ventricular zone (SVZ) is the major site of neurogenesis in the brain and is rich in neural stem cells. Based on the proximity of the GBM tumors to the SVZ, the tumors can be further classified into SVZ+ and SVZ−. The tumors located in close contact with the SVZ are classified as SVZ+, while the tumors located distantly from the SVZ are classified as SVZ−. To gain an insight into the increased aggressiveness of SVZ+ over SVZ− tumors, we have used proteomics techniques like 2D-DIGE and LC-MS/MS to investigate any possible proteomic differences between the two subtypes. Serum proteomic analysis revealed significant alterations of various acute phase proteins and lipid carrying proteins, while tissue proteomic analysis revealed significant alterations in cytoskeletal, lipid binding, chaperone and cell cycle regulating proteins, which are already known to be associated with disease pathobiology. These findings provide cues to molecular basis behind increased aggressiveness of SVZ+ GBM tumors over SVZ− GBM tumors and plausible therapeutic targets to improve treatment modalities for these highly invasive tumors.
Impact of platinum/pemetrexed combination versus other platinum-based regimens on adjuvant chemotherapy in resected lung adenocarcinoma
Authors: Zhai Xiaoyu , Zheng Qiwen , Yang Lu , Zhu Yixiang , Li Junling , Liu Yutao , Wang Ziping 
Published: April 2017

AbstractFor advanced non-squamous non-small cell lung cancer (NSCLC), although platinum/pemetrexed is known to result in a longer survival compared with other regimens, the outcome in the adjuvant setting is still unknown. In this study, the difference of the disease-free survival (DFS) between lung adenocarcinoma patients treated with platinum/pemetrexed and with other platinum-based doublets was concerned. A total of 389 radically resected lung adenocarcinoma patients received adjuvant chemotherapy with platinum/pemetrexed chemotherapy (Group A, n = 143) or other third generation platinum-based regimens (Group B, n = 246) were analyzed in terms of DFS. Propensity score matching (PSM) allowed generation of best matched pairs for the two categories. DFS was proved to be considerably better in pemetrexed doublets group (P = 0.0079); and platinum/pemetrexed was found to be associated with lower rates of several hematological and non-hematological adverse events (AEs), when compared with gemcitabine containing chemotherapy (leukopenia: RR 0.514, p = 0.001; neutropenia: RR 0.688, p = 0.002), or taxanes-doublets treatment (leukopenia: RR 0.685, p = 0.019; neutropenia: RR 0.805, p = 0.032). For patients with radically resected pulmonary adenocarcinoma, adjuvant chemotherapy with platinum/pemetrexed results in a better DFS and a less clinical toxicity in comparison with non-pemetrexed based doublets.
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis
Authors: Li Na , Xu Wenwen , Yuan Ying , Ayithan Natarajan , Imai Yasutomo , Wu Xuesong , Miller Halli , Olson Michael , Feng Yunfeng , Huang Yina H. , Jo Turk Mary , Hwang Samuel T. , Malarkannan Subramaniam , Wang Li 
Published: April 2017

AbstractV-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. Vsir−/− mice developed loss of peripheral tolerance and multi-organ chronic inflammatory phenotypes. Vsir−/− CD4+ and CD8+ T cells were hyper-responsive towards self- and foreign antigens. Whether or not VISTA regulates innate immunity is unknown. Using a murine model of psoriasis induced by TLR7 agonist imiquimod (IMQ), we show that VISTA deficiency exacerbated psoriasiform inflammation. Enhanced TLR7 signaling in Vsir−/− dendritic cells (DCs) led to the hyper-activation of Erk1/2 and Jnk1/2, and augmented the production of IL-23. IL-23, in turn, promoted the expression of IL-17A in both TCRγδ+ T cells and CD4+ Th17 cells. Furthermore, VISTA regulates the peripheral homeostasis of CD27− γδ T cells and their activation upon TCR-mediated or cytokine-mediated stimulation. IL-17A-producing CD27− γδ T cells were expanded in the Vsir−/− mice and amplified the inflammatory cascade. In conclusion, this study has demonstrated that VISTA critically regulates the inflammatory responses mediated by DCs and IL-17-producing TCRγδ+ and CD4+ Th17 T cells following TLR7 stimulation. Our finding provides a rationale for therapeutically enhancing VISTA-mediated pathways to benefit the treatment of autoimmune and inflammatory disorders.
Evaluating the utility of syndromic case management for three sexually transmitted infections in women visiting hospitals in Delhi, India
Authors: Sonkar Subash Chandra , Wasnik Kirti , Kumar Anita , Sharma Vineeta , Mittal Pratima , Mishra Prashant Kumar , Bharadwaj Mausumi , Saluja Daman 
Published: April 2017

AbstractUtility of syndromic case management (SCM) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. Consequently, antibiotic resistance has accelerated along with increased risk of infection to the partners. To understand the effectiveness and/or inadequacies of SCM, 11000 women were recruited and examined by clinicians for infection by Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), Bacterial vaginosis (BV) and others. Amongst these patients, 1797 (16.3%) reported vaginal discharge (VD). Other symptoms included: vaginitis (97%), cervicitis (75%), genital ulcers (60%), abnormal vaginal discharge (55%) and lower abdominal pain (48%). The patients were treated for single or co-infections using pre-packed National Aids Control Program III STI/RTI Kits. However, based on PCR diagnostics, 1453/1797 (81%) subjects were uninfected for NG/TV/CT. Amongst 344 (19%) infected patients, 257 (75%) carried infection with single pathogen (TV/NG/CT) while 87/344 (25%) were co-infected with multiple pathogens. Prevalence of TV, NG & CT was 4%, 7% and 8% respectively. Co-infection with CT + NG was highest, 51% (44/87), whereas, co-infection with CT + TV was 21% and NG + TV was 18% while co-infection with all three pathogens was 1.3%. We conclude that SCM is imprecise and successful intervention requires accurate and confirmatory diagnostic approach.
Correlates of insulin clearance in apparently healthy non-obese Japanese men
Authors: Kaga Hideyoshi , Tamura Yoshifumi , Takeno Kageumi , Kakehi Saori , Funayama Takashi , Furukawa Yasuhiko , Nishitani-Yokoyama Miho , Shimada Kazunori , Daida Hiroyuki , Aoki Shigeki , Giacca Adria , Kanazawa Akio , Kawamori Ryuzo , Watada Hirotaka 
Published: April 2017

AbstractHyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m2), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SSSI) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SSSI in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO2peak and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.
Omega-3 Long-Chain Polyunsaturated Fatty Acid Content and Oxidation State of Fish Oil Supplements in New Zealand
Authors: Bannenberg Gerard , Mallon Craig , Edwards Holly , Yeadon Derek , Yan Kevin , Johnson Holly , Ismail Adam 
Published: April 2017

AbstractForty-seven fish oil products available on the New Zealand market were analyzed for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) content, as well as for oxidative status in a collaborative effort by several analytical laboratories. Of the tested products, 72%, 86% and 77% complied with voluntary industry-set maximum limits on Peroxide Value (PV), para-Anisidine Value (p-AV), and TOTOX, respectively. 91% of the products complied with EPA/DHA content claims. All fish oils complied with a p-AV limit of 30, 98% with a PV limit of 10 meq O2/kg, and 96% with a calculated TOTOX value of 50, which are less stringent limits used by the European and British Pharmacopeia and the Australian authorities. The results are in stark contrast to the very low percentage of fish oil products reported to be in compliance with primary oxidation limits and EPA/DHA content by a recently published assessment of fish oil supplements in New Zealand. Possible reasons for this discrepancy are evaluated and discussed.
Spindle pole cohesion requires glycosylation-mediated localization of NuMA
Authors: Magescas Jérémy , Sengmanivong Lucie , Viau Amandine , Mayeux Adeline , Dang Tien , Burtin Martine , Nilsson Ulf J. , Leffler Hakon , Poirier Françoise , Terzi Fabiola , Delacour Delphine 
Published: April 2017

AbstractGlycosylation is critical for the regulation of several cellular processes. One glycosylation pathway, the unusual O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) has been shown to be required for proper mitosis, likely through a subset of proteins that are O-GlcNAcylated during metaphase. As lectins bind glycosylated proteins, we asked if specific lectins interact with mitotic O-GlcNAcylated proteins during metaphase to ensure correct cell division. Galectin-3, a small soluble lectin of the Galectin family, is an excellent candidate, as it has been previously described as a transient centrosomal component in interphase and mitotic epithelial cells. In addition, it has recently been shown to associate with basal bodies in motile cilia, where it stabilizes the microtubule-organizing center (MTOC). Using an experimental mouse model of chronic kidney disease and human epithelial cell lines, we investigate the role of Galectin-3 in dividing epithelial cells. Here we find that Galectin-3 is essential for metaphase where it associates with NuMA in an O-GlcNAcylation-dependent manner. We provide evidence that the NuMA-Galectin-3 interaction is important for mitotic spindle cohesion and for stable NuMA localization to the spindle pole, thus revealing that Galectin-3 is a novel contributor to epithelial mitotic progress.
Transition from Coherent to Stochastic electron heating in ultrashort relativistic laser interaction with structured targets
Authors: Cristoforetti G. , Londrillo P. , Singh P. K. , Baffigi F. , D’Arrigo G. , Lad Amit D. , Milazzo R. G. , Adak A. , Shaikh M. , Sarkar D. , Chatterjee G. , Jha J. , Krishnamurthy M. , Kumar G. R. , Gizzi L. A. 
Published: April 2017

AbstractRelativistic laser interaction with micro- and nano-scale surface structures enhances energy transfer to solid targets and yields matter in extreme conditions. We report on the comparative study of laser-target interaction mechanisms with wire-structures of different size, revealing a transition from a coherent particle heating to a stochastic plasma heating regime which occurs when migrating from micro-scale to nano-scale wires. Experiments and kinetic simulations show that large gaps between the wires favour the generation of high-energy electrons via laser acceleration into the channels while gaps smaller than the amplitude of electron quivering in the laser field lead to less energetic electrons and multi-keV plasma generation, in agreement with previously published experiments. Plasma filling of nano-sized gaps due to picosecond pedestal typical of ultrashort pulses strongly affects the interaction with this class of targets reducing the laser penetration depth to approximately one hundred nanometers. The two heating regimes appear potentially suitable for laser-driven ion/electron acceleration schemes and warm dense matter investigation respectively.
Serum anion gap at admission as a predictor of mortality in the pediatric intensive care unit
Authors: Kim Min Jung , Kim Yoon Hee , Sol In Suk , Kim Soo Yeon , Kim Jong Deok , Kim Ha Yan , Kim Kyung Won , Sohn Myung Hyun , Kim Kyu-Earn 
Published: April 2017

AbstractAn accurate method to predict the mortality in the intensive care unit (ICU) patients has been required, especially in children. The aim of this study is to evaluate the value of serum anion gap (AG) for predicting mortality in pediatric ICU (PICU). We reviewed a data of 461 pediatric patients were collected on PICU admission. Corrected anion gap (cAG), the AG compensated for abnormal albumin levels, was significantly lower in survivors compared with nonsurvivors (p < 0.001). Multivariable logistic regression analysis identified the following variables as independent predictors of mortality; cAG (OR 1.110, 95% CI 1.06–1.17; p < 0.001), PIM3 [OR 7.583, 95% CI 1.81–31.78; p = 0.006], and PRISM III [OR 1.076, 95% CI 1.02–1.14; p = 0.008]. Comparing AUCs for mortality prediction, there were no statistically significant differences between cAG and other mortality prediction models; cAG 0.728, PIM2 0.779, PIM3 0.822, and PRISM III 0.808. The corporation of cAG to pre-existing mortality prediction models was significantly more accurate at predicting mortality than using any of these models alone. We concluded that cAG at ICU admission may be used to predict mortality in children, regardless of underlying etiology. And the incorporation of cAG to pre-existing mortality prediction models might improve predictability.
Nonlinear graphene quantum capacitors for electro-optics
Authors: Khorasani Sina , Koottandavida Akshay 
Published: April 2017

AbstractOwing to its peculiar energy dispersion, the quantum capacitance property of graphene can be exploited in a two-dimensional layered capacitor configuration. Using graphene and boron nitride, respectively, as the electrodes and the insulating dielectric, a strongly nonlinear behavior at zero bias and small voltages is obtained. When the temperature is sufficiently low, the strong nonlinear interaction emerging from the quantum capacitance exhibits a diverse range of phenomena. The proposed structure could take over the functionalities of nonlinear elements in many cryogenic quantum systems, and in particular, quantum electro-optics. It is shown that ultrastrong coupling is easily reached with small number of pump photons at temperatures around 1 K and capacitor areas of the order of 1 μm2. A measure of anharmonicity is defined and as potential applications, a qubit design as well as schemes for non-reciprocal devices such as an electromagnetic frequency circulator are discussed.
Genome-wide identification, characterization, and expression profile of aquaporin gene family in flax (Linum usitatissimum)
Authors: Shivaraj S. M. , Deshmukh Rupesh K. , Rai Rhitu , Bélanger Richard , Agrawal Pawan K. , Dash Prasanta K. 
Published: April 2017

AbstractMembrane intrinsic proteins (MIPs) form transmembrane channels and facilitate transport of myriad substrates across the cell membrane in many organisms. Majority of plant MIPs have water transporting ability and are commonly referred as aquaporins (AQPs). In the present study, we identified aquaporin coding genes in flax by genome-wide analysis, their structure, function and expression pattern by pan-genome exploration. Cross-genera phylogenetic analysis with known aquaporins from rice, arabidopsis, and poplar showed five subgroups of flax aquaporins representing 16 plasma membrane intrinsic proteins (PIPs), 17 tonoplast intrinsic proteins (TIPs), 13 NOD26-like intrinsic proteins (NIPs), 2 small basic intrinsic proteins (SIPs), and 3 uncharacterized intrinsic proteins (XIPs). Amongst aquaporins, PIPs contained hydrophilic aromatic arginine (ar/R) selective filter but TIP, NIP, SIP and XIP subfamilies mostly contained hydrophobic ar/R selective filter. Analysis of RNA-seq and microarray data revealed high expression of PIPs in multiple tissues, low expression of NIPs, and seed specific expression of TIP3 in flax. Exploration of aquaporin homologs in three closely related Linum species bienne, grandiflorum and leonii revealed presence of 49, 39 and 19 AQPs, respectively. The genome-wide identification of aquaporins, first in flax, provides insight to elucidate their physiological and developmental roles in flax.
Grand-maternal smoking in pregnancy and grandchild’s autistic traits and diagnosed autism
Authors: Golding Jean , Ellis Genette , Gregory Steven , Birmingham Karen , Iles-Caven Yasmin , Rai Dheeraj , Pembrey Marcus 
Published: April 2017

AbstractAlthough there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother’s (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism. We find an association between maternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communication and Repetitive Behaviour measures that are independently predictive of diagnosed autism. In line with this, we show an association with actual diagnosis of autism in her grandchildren. Paternal grandmothers smoking in pregnancy showed no associations.
Integrated relaxation oscillator with no comparator for energy harvesting
Authors: Ma Yanzhao , Wang Danghui , Zhang Shengbing , Fan Xiaoya 
Published: April 2017

A fully‐integrated 12 kHz relaxation oscillator for energy harvesting application is presented. The oscillator has no comparator and no reference voltage. A conventional comparator has been replaced by a pseudo‐inverter chain to avoid comparator offset effect. Moreover, inverter threshold variation has no impact on the frequency. The circuit has been designed with 0.18 µm standard CMOS process. The oscillator operates in subthreshold region and consumes an ultra‐low power of 120 nW. A temperature coefficient of 31 ppm/°C has been achieved over −40 to 90°C.
Ocean Size and Corresponding Life History Diversity among the Four Run Timings of California Central Valley Chinook Salmon
Authors: Satterthwaite William H. , Carlson Stephanie M. , Criss Anne 
Published: April 2017

AbstractWe used coded wire tag data to compare spawner age structure and seasonal patterns of age‐specific size at date among fish harvested in the ocean from the four seasonal run timings (fall, late‐fall, winter, and spring) of Chinook Salmon Oncorhynchus tshawytscha from the Central Valley, California, and we examined differences between the fall‐run fish (the most abundant run) from the Sacramento and San Joaquin River basins. The runs varied in their ocean size at a common age and date, and within each run, monthly mean ocean sizes appeared to stop increasing when spawners began to return to freshwater. Despite support for multiple hypotheses, no single factor explained all of the variation among and within runs. Ocean size at a common date was well explained by a “juvenile head‐start” hypothesis, predicting larger sizes for the spring and fall runs due to earlier ocean entry. Month of spawner return was well explained by a “premature adult migration” hypothesis, predicting earlier returns (within years, regardless of age) by winter‐ and spring‐run fish spawning further upstream. However, neither release timing nor spawning elevation could fully explain observed patterns in spawner age structure, such as an unusually high occurrence of age‐2 San Joaquin River fall‐run spawners and the near absence of age‐4 or older spawners in the winter run. Larger smolt size might explain earlier maturation by the San Joaquin versus Sacramento River fall run, but smolt size could not explain patterns in age structure across runs. Metabolic costs of holding upstream with large size might explain the lack of older spawners among the winter run but are inconsistent with the late‐fall run having the highest frequency of age‐4 and older spawners. Our results demonstrate multiple pathways by which differences both within and among the runs may contribute to differences in their fishery vulnerability and demographic decoupling, which could contribute to a stabilizing portfolio effect.Received August 29, 2016; accepted February 2, 2017 Published online April 27, 2017
The Economic Impacts of 2015 Avian Influenza Outbreak on the U.S. Turkey Industry and the Loss Mitigating Role of Free Trade Agreements
Authors: Çakır Metin , Boland Michael A , Wang Yanghao 
Published: April 2017

AbstractWe investigate the economic impacts of the 2015 HPAI outbreak on turkey producers in Minnesota and the United States. Using a partial equilibrium model of the meat and poultry industry we find that the cost of the outbreak to U.S turkey producers was $225 million; $207 million of which were due to the loss in exports. However, it could have been worse if not for implementation of regional bans by trading partners who have negotiated free trade agreements with the United States. Our results show that for every percentage point of additional exports, U.S. turkey producers avoided a loss of about $6 million.