bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staging the “Stolen Transition”: Conspiracy and Collusion in Postsocialist Crime Fiction
Authors: Pluwak Anita 
Published: September 2024

AbstractThis article explores how three popular crime novels from the 2000s articulate postsocialist Poland’s most prevalent conspiracy narrative: that of a hidden network (układ) of communist-era secret service agents that have allegedly penetrated the structures and economy of the post-1989 state, thus “stealing” the transition to democracy and capitalism, and making it impossible for the new system to thrive. Whereas previous research has dealt mainly with the political content of this narrative and the way it has been employed in political discourse, this article focuses on its cultural significance and the multiple anxieties from which it stems, including a growing sense of diminished human autonomy and a generalized suspicion of social systems. The paper contributes to a growing body of work on postsocialist conspiracy narratives that takes an increasingly transnational and comparative approach. The novels analyzed in the paper are Zygmunt Miłoszewski’s Uwikłanie (Entanglement, 2007), Marcin Wolski’s Noblista (Nobel Prize Winner, 2008) and Szczepan Twardoch’s Przemienienie (Transfiguration, 2008).
Archeologists Imagine Ukraine: Social Scientists and Nation Building in the Nineteenth Century
Authors: McReynolds Louise 
Published: September 2024

AbstractRussia’s brutal invasion in February 2022 revitalized considerations about how Ukraine can contribute to historiographical issues related to the origins of nation-statehood. This essay contributes to that discussion by returning to the 19th century and exploring how the participants in multiple archeological congresses, nascent social scientists confident in the empirical objectivity of their evidence, envisioned Ukraine. Borrowing from Benedict Anderson’s commonplace about a nation as an “imagined community,” I highlight the contestation between nationalist and imperialist discourses in the emergent social sciences. Although the Versailles Peace Conference, which denied Ukraine the opportunity to “self-determine” as a modern political entity, revealed the limits of the Western political imagination in 1919, many of the ideas presented at these congresses continue to inform the cultural and geographical borders of Ukraine.
The Politics of Anti-Imperial Nostalgia: South Africa's Response to the Russian Invasion of Ukraine
Authors: Loyd Thom 
Published: September 2024

AbstractWhen the UN General Assembly condemned the Russian invasion of Ukraine and called for the immediate withdrawal of Russian forces in March 2022, barely half of African states voted in favor. This lukewarm support contrasted with strong support for Ukraine elsewhere in the world. Among those abstaining from the vote was South Africa, a country with a long history of interaction with the post-Soviet space. This essay considers the interplay of historical remembering and forgetting that has contributed to the South African response to Russia’s invasion of Ukraine. A longstanding commitment to non-alignment, the long shadow of the anti-colonial struggle, and the complicated legacy of the Soviet Union, its collapse, and who rightly carries its anti-apartheid mantle, have all played a role in shaping the South African response.
Is Russia Losing in Ukraine but Winning in the Global South?
Authors: Stoner Kathryn 
Published: September 2024

AbstractRussia’s war in Ukraine has been roundly condemned in the West. NATO members have continued to supply Ukraine with weaponry while the EU, US and their allies have ensured that the Russian economy remains under the most extensive and intensive set of sanctions in history. Yet many leaders of countries in the global south have been far more hesitant to condemn Russian actions. Some have merely abstained in United Nations resolutions criticizing Russia, while others have remained neutral. This paper will endeavor to explain why the global south has such a different perspective from the global north on Russia’s war in Ukraine. I argue that this is a result of America’s withdrawal from the global south over the last two decades and Russia’s reemergence in many parts of the Middle East, Sub Saharan Africa, Latin America and Asia.
Mixing and Water Mass Transformation Over Discovery Bank, in the Weddell‐Scotia Confluence of the Southern Ocean
Authors: Brearley J. Alexander , Girton James B. , Lucas Natasha S. , Thurnherr Andreas M. , Abrahamsen E. Povl , Meredith Michael P. , Meijers Andrew S. , Venables Hugh J. 
Published: September 2024

AbstractThe South Scotia Ridge, in the Atlantic sector of the Southern Ocean, is a key region for water mass modification. It is the location of the Weddell‐Scotia Confluence, an area of reduced stratification which separates the Weddell Gyre to the south and the Antarctic Circumpolar Current to the north, and which receives input of shelf waters from the tip of the Antarctic Peninsula. To elucidate the transformations over the ridge, we focus on one of its largest seamounts, Discovery Bank, which has previously been observed as hosting a stratified Taylor column that retains water for months to years, during which time water masses are entrained from north and south of the Weddell Front and steadily mixed. Data from ship‐deployed sensors and autonomous platforms are analyzed to quantify and understand the diapycnal mixing, heat fluxes and water mass transformations over the bank. Ocean glider and free‐profiling drifting float data show that the mid‐depth temperature maximum of the Circumpolar Deep Water (CDW) is eroded between the northern and southern sides of the bank, while diapycnal diffusivity is enhanced by up to an order‐of‐magnitude over its steeply sloping portions. This is accompanied by heat fluxes from the CDW layer being increased by up to a factor of six, which may contribute to a reduction in mid‐depth stratification. Tidal model analysis shows that the southern side of the bank hosts strong barotropic to baroclinic energy conversion (>150 N m−2), emphasizing the role of internal tides in modulating water mass transformations in the Confluence.
One Billion Years of Stability in the North American Midcontinent Following Two‐Stage Grenvillian Structural Inversion
Authors: Hodgin Eben B. , Swanson‐Hysell Nicholas L. , Kylander‐Clark Andrew R. C. , Turner Andrew C. , Stolper Daniel A. , Ibarra Daniel E. , Schmitz Mark D. , Zhang Yiming , Fairchild Luke M. , Fuentes Anthony J. 
Published: September 2024

AbstractThe North American craton interior preserves a >1 Ga history of near surface processes that inform ongoing debates regarding timing and drivers of continental‐scale deformation and erosion associated with far‐field orogenesis. We tested various models of structural inversion on a major segment of the Midcontinent Rift along the Douglas Fault in northern Wisconsin, which accommodated ≳10 km of total vertical displacement. U‐Pb detrital zircon and vein calcite Δ47/U‐Pb thermochronometry from the hanging wall constrain the majority of uplift (≳8.5 km) and deformation to 1052–1036 Ma during the Ottawan phase of the Grenvillian orogeny. Combined U‐Pb zircon dates, Δ47/U‐Pb calcite thermochronometry, and field data that document syn‐ to early post‐depositional deformation in the footwall constrain a second stage of uplift (1–1.5 km) ca. 995–980 Ma during the Rigolet phase of the Grenvillian orogeny. A minor phase of Appalachian far‐field orogenesis is associated with minimal thrust reactivation. Our combined analyses identified the 995–980 Ma Bayfield Group as a Grenvillian foreland basin with an original thickness 0.5–2 km greater than currently preserved. By quantifying flexural loading and other subsidence mechanisms along the Douglas Fault, we identify dynamic subsidence as a mechanism that could be consistent with the development of late‐Grenvillian transcontinental fluvial systems. Minimal post‐Grenvillian erosion (0.5–2 km) in this part of the craton interior has preserved the Bayfield Group and equivalent successions, limiting the magnitude of regional erosion that can be attributed to Neoproterozoic glaciation.
Improving Discharge Predictions in Ungauged Basins: Harnessing the Power of Disaggregated Data Modeling and Machine Learning
Authors: Muhebwa Aggrey , Gleason Colin J. , Feng Dongmei , Taneja Jay 
Published: September 2024

AbstractCurrent machine learning methods for discharge prediction often employ aggregated basin‐wide hydrometeorological data (lumped modeling) for parametric and non‐parametric training. This approach may overlook the spatial heterogeneity of river systems and their impact on discharge patterns. We hypothesize that integrating spatiotemporal hydrologic knowledge into the data modeling process (distributed/disaggregated modeling) can improve the performance of discharge prediction models. To test this hypothesis, we designed experiments comparing the performance of identical Long Short‐Term Memory Recurrent Neural Network (LSTM‐RNN) models forced with either lumped or distributed features. We gather meteorological forcing and static attributes for the Mackenzie basin in Canada‐ a large and unique basin. Importantly, discharge performance is assessed out‐of‐sample with k‐fold replication across gauges. Training LSTMs with disaggregated data significantly improved model accuracy. Specifically, there was a 9.6% increase in the mean Nash‐Sutcliffe Efficiency and a 4.6% increase in the mean Kling‐Gupta Efficiency, indicating a better agreement between predicted and actual observations in terms of mean, variability, and correlation. These experiments and results demonstrate the importance of integrating topologically guided geomorphologic and hydrologic information (distributed modeling) in data‐driven discharge predictions.
BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma
Authors: Bisceglia Luisa , Morani Federica , Guerrieri Lara , Santoni-Rugiu Eric , Çakılkaya Pınar , Scatena Cristian , Scarpitta Rosa , Engelholm Lars H. , Behrendt Niels , Gemignani Federica , Landi Stefano 
Published: September 2024

AbstractMalignant pleural mesothelioma (MPM) is an aggressive cancer with a poor prognosis and the identification of novel druggable targets is urgently needed. In previous work, we identified 15 deregulated genes highly expressed in MPM tissues and correlated with a poor prognosis. Here, we validated these findings on an independent dataset of 211 MPM patients (EGA, EGAD00001001915) and on a panel of MPM cell lines. Furthermore, we carried out in vitro gene silencing followed by proliferation, cytotoxicity, caspase, and migration assays to define whether these targets could be cancer-driver genes. We ended up with three novel candidates (i.e., BAG2, MAD2L1, and MDK), whose encoded proteins could be exploited as druggable targets. Moreover, of novelty, immunohistochemistry analysis on tissues revealed that the overexpression of BAG2 and MAD2L1 could differentiate MPM from RMP patients. Furthermore, when we tested Neratinib (an inhibitor of MAD2L1) and iMDK (an inhibitor of MDK) we found that they are effective on MPM cells, in part phenocopying the effects of MAD2L1 and MDK gene silencing. In summary, in the present work, we report that BAG2, MAD2L1, and MDK are bona fide cancer-driver genes for MPM worth of further studies.
The functional role of m6A demethylase ALKBH5 in cardiomyocyte hypertrophy
Authors: Meng Chen , Su Haibi , Shu Meiling , Shen Feng , Lu Yijie , Wu Shishi , Su Zhenghua , Yu Mengyao , Yang Di 
Published: September 2024

AbstractCardiomyocyte hypertrophy is a major outcome of pathological cardiac hypertrophy. The m6A demethylase ALKBH5 is reported to be associated with cardiovascular diseases, whereas the functional role of ALKBH5 in cardiomyocyte hypertrophy remains confused. We engineered Alkbh5 siRNA (siAlkbh5) and Alkbh5 overexpressing plasmid (Alkbh5 OE) to transfect cardiomyocytes. Subsequently, RNA immunoprecipitation (RIP)-qPCR, MeRIP-qPCR analysis and the dual-luciferase reporter assays were applied to elucidate the regulatory mechanism of ALKBH5 on cardiomyocyte hypertrophy. Our study identified ALKBH5 as a new contributor of cardiomyocyte hypertrophy. ALKBH5 showed upregulation in both phenylephrine (PE)-induced cardiomyocyte hypertrophic responses in vitro and transverse aortic constriction (TAC)/high fat diet (HFD)-induced pathological cardiac hypertrophy in vivo. Knockdown or overexpression of ALKBH5 regulated the occurrence of hypertrophic responses, including the increased cardiomyocyte surface areas and elevation of the hypertrophic marker levels, such as brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP). Mechanically, we indicated that ALKBH5 activated JAK2/STAT3 signaling pathway and mediated m6A demethylation on Stat3 mRNA, but not Jak2 mRNA, resulting in the phosphorylation and nuclear translocation of STAT3, which enhances the transcription of hypertrophic genes (e.g., Nppa) and ultimately leads to the emergence of cardiomyocytes hypertrophic growth. Our work highlights the functional role of ALKBH5 in regulating the onset of cardiomyocyte hypertrophy and provides a potential target for hypertrophic heart diseases prevention and treatment.
Effect of fruits granola (Frugra®) consumption on blood pressure reduction and intestinal microbiome in patients undergoing hemodialysis
Authors: Nagasawa Hajime , Suzuki Shogo , Kobayashi Takashi , Otsuka Tomoyuki , Okuma Teruyuki , Matsushita Satoshi , Amano Atsushi , Shimizu Yoshio , Suzuki Yusuke , Ueda Seiji 
Published: September 2024

AbstractCardiovascular diseases (CVDs) are a major cause of death in patients undergoing hemodialysis (HD). Blood pressure (BP) and uremic toxins are well-known risk factors for CVDs, which are influenced by diet. Dietary fiber supplementation in patients undergoing HD may reduce the risk of CVDs by improving lipid profiles and inflammatory status and lowering the levels of the uremic toxin indoxyl sulfate (IS). In this study, we investigated the relationship between the intestinal microbiota and risk factors for CVDs, such as BP and serum IS, in patients undergoing HD who consumed fruits granola (FGR). The study participants were selected from patients undergoing HD at the Izu Nagaoka Daiichi Clinic and consumed FGR for 2 months. Body composition and blood samples were tested at months 0, 1, 2 and fecal samples were collected at months 0 and 2 for intestinal microbiota analysis. FGR consumption decreased systolic and diastolic BP, estimated salt intake, and serum IS levels and improved the stool characteristics according to the Bristol Stool Form Scale (N = 24). Gut microbiota analysis showed an increase in the alpha diversity and abundance of Blautia and Neglecta. The abundance of lactic acid- and ethanol-producing bacteria also significantly increased, whereas the abundance of indole-producing bacteria significantly decreased. FGR consumption could be a useful tool for salt reduction, fiber supplementation, and improvement of the intestinal environment, thus contributing to improvement of BP and the reduction of other risk factors for CVDs in patients undergoing HD.
Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections
Authors: Nooruzzaman Mohammed , Johnson Katherine E. E. , Rani Ruchi , Finkelsztein Eli J. , Caserta Leonardo C. , Kodiyanplakkal Rosy P. , Wang Wei , Hsu Jingmei , Salpietro Maria T. , Banakis Stephanie , Albert Joshua , Westblade Lars F. , Zanettini Claudio , Marchionni Luigi , Soave Rosemary , Ghedin Elodie , Diel Diego G. , Salvatore Mirella 
Published: September 2024

AbstractWe investigated the impact of antiviral treatment on the emergence of SARS-CoV-2 resistance during persistent infections in immunocompromised patients (n = 15). All patients received remdesivir and some also received nirmatrelvir-ritonavir (n = 3) or therapeutic monoclonal antibodies (n = 4). Sequence analysis showed that nine patients carried viruses with mutations in the nsp12 (RNA dependent RNA polymerase), while four had viruses with nsp5 (3C protease) mutations. Infectious SARS-CoV-2 with a double mutation in nsp5 (T169I) and nsp12 (V792I) was recovered from respiratory secretions 77 days after initial COVID-19 diagnosis from a patient sequentially treated with nirmatrelvir-ritonavir and remdesivir. In vitro characterization confirmed its decreased sensitivity to remdesivir and nirmatrelvir, which was overcome by combined antiviral treatment. Studies in golden Syrian hamsters demonstrated efficient transmission to contact animals. This study documents the isolation of SARS-CoV-2 carrying resistance mutations to both nirmatrelvir and remdesivir from a patient and demonstrates its transmissibility in vivo.
SymProFold: Structural prediction of symmetrical biological assemblies
Authors: Buhlheller Christoph , Sagmeister Theo , Grininger Christoph , Gubensäk Nina , Sleytr Uwe B. , Usón Isabel , Pavkov-Keller Tea 
Published: September 2024

AbstractSymmetry in nature often emerges from self-assembly processes and serves a wide range of functions. Cell surface layers (S-layers) form symmetrical lattices on many bacterial and archaeal cells, playing essential roles such as facilitating cell adhesion, evading the immune system, and protecting against environmental stress. However, the experimental structural characterization of these S-layers is challenging due to their self-assembly properties and high sequence variability. In this study, we introduce the SymProFold pipeline, which utilizes the high accuracy of AlphaFold-Multimer predictions to derive symmetrical assemblies from protein sequences, specifically focusing on two-dimensional S-layer arrays and spherical viral capsids. The pipeline tests all known symmetry operations observed in these systems (p1, p2, p3, p4, and p6) and identifies the most likely symmetry for the assembly. The predicted models were validated using available experimental data at the cellular level, and additional crystal structures were obtained to confirm the symmetry and interfaces of several SymProFold assemblies. Overall, the SymProFold pipeline enables the determination of symmetric protein assemblies linked to critical functions, thereby opening possibilities for exploring functionalities and designing targeted applications in diverse fields such as nanotechnology, biotechnology, medicine, and materials and environmental sciences.
Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia
Authors: Peretz Cheryl A. C. , Kennedy Vanessa E. , Walia Anushka , Delley Cyrille L. , Koh Andrew , Tran Elaine , Clark Iain C. , Hayford Corey E. , D’Amato Chris , Xue Yi , Fontanez Kristina M. , May-Zhang Aaron A. , Smithers Trinity , Agam Yigal , Wang Qian , Dai Hai-ping , Roy Ritu , Logan Aaron C. , Perl Alexander E. , Abate Adam , Olshen Adam , Smith Catherine C. 
Published: September 2024

AbstractDespite recent work linking mixed phenotype acute leukemia (MPAL) to certain genetic lesions, specific driver mutations remain undefined for a significant proportion of patients and no genetic subtype is predictive of clinical outcomes. Moreover, therapeutic strategy for MPAL remains unclear, and prognosis is overall poor. We performed multiomic single cell profiling of 14 newly diagnosed adult MPAL patients to characterize the inter- and intra-tumoral transcriptional, immunophenotypic, and genetic landscapes of MPAL. We show that neither genetic profile nor transcriptome reliably correlate with specific MPAL immunophenotypes. Despite this, we find that MPAL blasts express a shared stem cell-like transcriptional profile indicative of high differentiation potential. Patients with the highest differentiation potential demonstrate inferior survival in our dataset. A gene set score, MPAL95, derived from genes highly enriched in the most stem-like MPAL cells, is applicable to bulk RNA sequencing data and is predictive of survival in an independent patient cohort, suggesting a potential strategy for clinical risk stratification.
Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Authors: Engesser Jonas , Khatri Robin , Schaub Darius P. , Zhao Yu , Paust Hans-Joachim , Sultana Zeba , Asada Nariaki , Riedel Jan-Hendrik , Sivayoganathan Varshi , Peters Anett , Kaffke Anna , Jauch-Speer Saskia-Larissa , Goldbeck-Strieder Thiago , Puelles Victor G. , Wenzel Ulrich O. , Steinmetz Oliver M. , Hoxha Elion , Turner Jan-Eric , Mittrücker Hans-Willi , Wiech Thorsten , Huber Tobias B. , Bonn Stefan , Krebs Christian F. , Panzer Ulf 
Published: September 2024

AbstractAntineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN relies on non-specific immunosuppressive agents, which may have serious adverse effects and be only partially effective. Here, using spatial and single-cell transcriptome analysis, we characterize inflammatory niches in kidney samples from 34 patients with ANCA-GN and identify proinflammatory, cytokine-producing CD4+ and CD8+ T cells as a pathogenic signature. We then utilize these transcriptomic profiles for digital pharmacology and identify ustekinumab, a monoclonal antibody targeting IL-12 and IL-23, as the strongest therapeutic drug to use. Moreover, four patients with relapsing ANCA-GN are treated with ustekinumab in combination with low-dose cyclophosphamide and steroids, with ustekinumab given subcutaneously (90 mg) at weeks 0, 4, 12, and 24. Patients are followed up for 26 weeks to find this treatment well-tolerated and inducing clinical responses, including improved kidney function and Birmingham Vasculitis Activity Score, in all ANCA-GN patients. Our findings thus suggest that targeting of pathogenic T cells in ANCA-GN patients with ustekinumab might represent a potential approach and warrants further investigation in clinical trials.
Maintenance and transformation of representational formats during working memory prioritization
Authors: Pacheco-Estefan Daniel , Fellner Marie-Christin , Kunz Lukas , Zhang Hui , Reinacher Peter , Roy Charlotte , Brandt Armin , Schulze-Bonhage Andreas , Yang Linglin , Wang Shuang , Liu Jing , Xue Gui , Axmacher Nikolai 
Published: September 2024

AbstractVisual working memory depends on both material-specific brain areas in the ventral visual stream (VVS) that support the maintenance of stimulus representations and on regions in the prefrontal cortex (PFC) that control these representations. How executive control prioritizes working memory contents and whether this affects their representational formats remains an open question, however. Here, we analyzed intracranial EEG (iEEG) recordings in epilepsy patients with electrodes in VVS and PFC who performed a multi-item working memory task involving a retro-cue. We employed Representational Similarity Analysis (RSA) with various Deep Neural Network (DNN) architectures to investigate the representational format of prioritized VWM content. While recurrent DNN representations matched PFC representations in the beta band (15–29 Hz) following the retro-cue, they corresponded to VVS representations in a lower frequency range (3–14 Hz) towards the end of the maintenance period. Our findings highlight the distinct coding schemes and representational formats of prioritized content in VVS and PFC.