bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolved astrometric orbits of ten O-type binaries
Authors: Le Bouquin J.-B. , Sana H. , Gosset E. , De Becker M. , Duvert G. , Absil O. , Anthonioz F. , Berger J.-P. , Ertel S. , Grellmann R. , Guieu S. , Kervella P. , Rabus M. , Willson M. 
Published: August 2016

Aims. Our long-term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2).
Methods. We followed-up ten O+O binaries with AMBER, PIONIER and GRAVITY at the VLTI. Here, we report on 130 astrometric observations over the last seven years. We combined this dataset with distance estimates to compute the total mass of the systems. We also computed preliminary individual component masses for the five systems with available SB2 radial velocities.
Results. Nine of the ten binaries have their three-dimensional orbit well constrained. Four of them are known to be colliding wind, non-thermal radio emitters, and thus constitute valuable targets for future high angular resolution radio imaging. Two binaries break the correlation between period and eccentricity tentatively observed in previous studies. This suggests either that massive star formation produces a wide range of systems, or that several binary formation mechanisms are at play. Finally, we found that the use of existing SB2 radial velocity amplitudes can lead to unrealistic masses and distances.
Conclusions. If not understood, the biases in radial velocity amplitudes will represent an intrinsic limitation for estimating dynamical masses from SB2+interferometry or SB2+Gaia. Nevertheless, our results can be combined with future Gaia astrometry to measure the dynamical masses and distances of the individual components with an accuracy of 5 to 15%, completely independently of the radial velocities.
A new correlation clustering method for cancer mutation analysis
Authors: Hou Jack P. , Emad Amin , Puleo Gregory J. , Ma Jian , Milenkovic Olgica 
Published: August 2016

Motivation: Cancer genomes exhibit a large number of different alterations that affect many genes in a diverse manner. An improved understanding of the generative mechanisms behind the mutation rules and their influence on gene community behavior is of great importance for the study of cancer.
Results: To expand our capability to analyze combinatorial patterns of cancer alterations, we developed a rigorous methodology for cancer mutation pattern discovery based on a new, constrained form of correlation clustering. Our new algorithm, named C3 (Cancer Correlation Clustering), leverages mutual exclusivity of mutations, patient coverage and driver network concentration principles. To test C3, we performed a detailed analysis on TCGA breast cancer and glioblastoma data and showed that our algorithm outperforms the state-of-the-art CoMEt method in terms of discovering mutually exclusive gene modules and identifying biologically relevant driver genes. The proposed agnostic clustering method represents a unique tool for efficient and reliable identification of mutation patterns and driver pathways in large-scale cancer genomics studies, and it may also be used for other clustering problems on biological graphs.
Availability and Implementation: The source code for the C3 method can be found at https://github.com/jackhou2/C3
Contacts: jianma@cs.cmu.edu or milenkov@illinois.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Temporal Trends in Anesthesia-related Adverse Events in Cesarean Deliveries, New York State, 2003 to 2012
Authors: Guglielminotti J. , Wong C.A. , Landau R. , Li G. 
Published: August 2016

(Anesthesiology. 2015;123(5):1013–1023)
In 2010, 1.3 million women in the United States underwent cesarean delivery, making it the most common inpatient surgery in the country. Despite the pervasiveness of this procedure, it is associated with a heightened risk of anesthesia-related adverse events when compared with vaginal delivery. It is also associated with an increased risk of nonanesthetic perioperative morbidity and mortality. The goal of this study was to evaluate these anesthesia-related adverse events in terms of temporal trends. The authors also examined nonanesthetic perioperative complications, and overall mortality related to cesarean deliveries.
Determination of Base Excess in Umbilical Cord Blood at Birth: Accessory or Excess?
Authors: Olofsson P. 
Published: August 2016

(Am J Obstet Gynecol. 2015;213(3):259–261)
In newborns, acidemia can be common, but if it is caused by hypoxia with anaerobic metabolism, it can signal future morbidities. Since it was first proposed in the 1950s, base excess in umbilical cord blood at birth has been used to measure nonrespiratory acid-base status in infants. As most base excess scores are negative at birth, the phrase base deficit can be used synonymously. The reasoning behind considering this measure in relation to pH levels is to differentiate respiratory and metabolic acidemia.
Failed Tracheal Intubation During Obstetric General Anaesthesia: A Literature Review
Authors: Kinsella S.M. , Winton A.L. , Mushambi M.C. , Ramaswamy K. , Swales H. , Quinn A.C. , Popat M. 
Published: August 2016

(Int J Obstet Anesth. 2015;24(4):356–374)
Failed tracheal intubation guidelines for obstetrics were first developed by Michael Tunstall at Aberdeen Maternity Hospital in the 1970s. Multiple versions of these original guidelines spread through local adaptation. The American Society of Anesthesiologists produced official national guidelines on management of the difficult airway in 1992, and these were last updated in 2013. Similar guidelines were developed by the Difficult Airway Society (DAS) for the United Kingdom in 2004. These do not address issues specific to the obstetric patient, however. Developments in obstetric anesthesia practice that have taken place since Tunstall introduced his guidelines include availability of supraglottic airway devices (SAD), antacid and oral intake protocols during labor, rapid onset nondepolarizing neuromuscular blocking drugs, and rapid neuromuscular reversal agents. Use of neuraxial anesthesia for cesarean section has increased, and up to one third of obstetric general anesthetics are now administered after failed neuraxial anaesthesia. The Obstetric Anaesthetists’ Association (OAA) and DAS have just published stand-alone obstetric failed intubation guidelines. The primary aim of this study was to search the relevant literature for evidence to support these guidelines, with special focus on quantitative data to estimate incidences of difficult airway management, management options, and maternal and neonatal outcomes.
Uterine Exteriorization Compared With In Situ Repair for Cesarean Delivery: A Systematic Review and Meta-Analysis
Authors: Zaphiratos V. , George R.B. , Boyd J.C. , Habib A.S. 
Published: August 2016

(Can J Anaesth. 2015;62(11):1209–1220)
In 2009, a meta-analysis was published comparing 2 different methods of uterine repair: uterine exteriorization and in situ repair. Over 3000 patients were included in this analysis, which showed no noticeable difference in outcomes between the 2 methods. Since then, 5 trials have been published comparing these 2 methods, increasing the studied patient population to over 16,000. With this wealth of data coming from a series of new trials, the authors of this paper undertook a systematic review and meta-analysis comparing perioperative outcomes for uterine exteriorization versus in situ repair during cesarean delivery.
Morbidity Associated With Cesarean Delivery in the United States: Is Placenta Accreta an Increasingly Important Contributor?
Authors: Creanga A.A. , Bateman B.T. , Butwick A.J. , Raleigh L. , Maeda A. , Kuklina E. , Callaghan W.M. 
Published: August 2016

(Am J Obstet Gynecol. 2015;213(3):384.e1–e11)
In the United States, 1.3 million women underwent cesarean delivery in 2012 alone. The fact that this is such a common surgery may have led to a heightened sense of safety surrounding the procedure despite the fact that it is associated with serious risks such as placenta accreta, which can result in major obstetric morbidity. The authors of this study investigated morbidity associated with both first and repeat cesarean deliveries with a special emphasis on placenta accreta. They also attempted to identify potential factors related to types of hospitals and patient demographics that might be associated with increased risk of such morbidity.
Does Spinal Block Through Tattooed Skin Cause Histological Changes in Nervous Tissue and Meninges? An Experimental Model in Rabbits
Authors: Ferraz I.L. , Barros G.A. , Ferreira Neto P.G. , Solanki D. , Marques M.A. , Machado V.M. , Cabral L.W. , Lima R.M. , Vianna P.T. , Navarro L.H. , Ganen E.M. 
Published: August 2016

(Reg Anesth Pain Med. 2015;40(5):533–538)
As tattoos continue to become a more pervasive cultural trend, it is increasingly likely for anesthesiologists to encounter patients with tattoos covering their lumbar and sacral area. Although there are currently no reports of complications from placing a needle through tattooed skin, there are also insufficient data to determine whether it is completely safe. Concerns are that ink fragments, which may contain carcinogenic amides, can be accidentally deposited in the subarachnoid space, leading to arachnoiditis. The authors of this study investigated whether placing a 22-G spinal needle through tattooed skin could result in changes to the spinal cord and meninges or if fragments of ink could become trapped in the needle bore.
Trajectory of Platelets in Pregnancy: Do Low-risk Women Need an Intrapartum Full Blood Count Prior to Epidural?
Authors: Duong C. , Kidson-Gerber G. , Peters N. , Listijono D.R. , Henry A. 
Published: August 2016

(Aust N Z J Obstet Gynaecol. 2015;55(5):511–514)
Thrombocytopenia, defined as a platelet count <150×109/L, occurs in 7% to 10% of pregnancies. There is no clear agreement as to whether women who are determined to be low risk for thrombocytopenia need a platelet count before intrapartum epidural analgesia can be administered and awaiting this laboratory value could delay epidural administration. As women typically receive a full blood count around 28 weeks of gestation, the authors of this study sought to determine whether women with normal platelet levels during that routine check-up and overall low risk of thrombocytopenia tended to maintain a normal platelet count up until the peripartum period.
Bedside Gastric Ultrasonography in Term Pregnant Women Before Elective Cesarean Delivery: A Prospective Cohort Study
Authors: Arzola C. , Perlas A. , Siddiqui N.T. , Carvalho J.A. 
Published: August 2016

(Anesth Analg. 2015;121:752–758)
Bedside ultrasonography can be used to establish the gastric contents of pregnant women about to undergo general anesthesia for elective cesarean delivery. This could help avoid the serious complication of pulmonary aspiration by prompting anesthesiologists to discourage general anesthesia in a woman found to have a full stomach. In the past ultrasonography was not able to detect an empty stomach, but technological improvements have made this a possibility. This study investigated the qualitative and quantitative sonographic patterns of the gastric antrum in fasted pregnant patients.
Anal Incontinence Among First Time Mothers: What Happens in Pregnancy and the First Year After Delivery?
Authors: Johannessen H.H. , Wibe A. , Stordahl A. , Sandvik L. , Mørkved S. 
Published: August 2016

(Acta Obstet Gynecol Scand. 2015;94(9):1005–1013)
The fundamental physical processes responsible for anal incontinence are not entirely understood. At the group level, it is typical for first time mothers to experience this problem during late pregnancy and the first postpartum year, but it is not yet clear why this is the case. The authors of this study investigated changes in continence status among individual healthy primiparous women from late pregnancy to the first postpartum year. The authors also sought to determine factors that might be associated with persistent anal incontinence and new onset incontinence at 1 year postpartum.
Recurrent Preeclampsia in Women With Metabolic Syndrome and Low Plasma Volume: A Retrospective Cohort Study
Authors: Stekkinger E. , Scholten R.R. , Heidema W.M. , Spaanderman M.E.A. 
Published: August 2016

(BJOG. 2015;122(13):1773–1780)
Preeclampsia occurs in 2% to 8% of pregnancies and is associated with significant maternal and perinatal morbidity and mortality. Women with a history of preeclampsia are at increased risk for preeclampsia in subsequent pregnancies. The aim of this study was to determine the prevalence of recurrent preeclampsia in women who have been diagnosed with metabolic syndrome and/or low plasma volume compared with women who have a history of preeclampsia but neither of these pathologic conditions.
Maternal and Neonatal Morbidity After Attempted Operative Vaginal Delivery According to Fetal Head Station
Authors: Ducarme G. , Hamel J.-F. , Bouet P.-E. , Legendre G. , Vandenbroucke L. , Sentilhes L. 
Published: August 2016

(Obstet Gynecol. 2015;126:521–529)
It has been suggested that midpelvic operative vaginal delivery methods (eg, vacuum extraction, Thierry’s spatulas, or forceps) might significantly increase maternal and neonatal morbidity. However, the data are not up-to-date. Subsequently, the authors of the present study assessed severe maternal and neonatal morbidity after attempted operative vaginal delivery and also compared morbidity after midpelvic and low pelvic delivery attempts.
Maternal and Fetal Morbidity Associated With Uterine Rupture of the Unscarred Uterus
Authors: Gibbins K.J. , Weber T. , Holmgren C.M. , Porter T.F. , Varner M.W. , Manuck T.A. 
Published: August 2016

(Am J Obstet Gynecol. 2015;213:382.e1–e6)
Uterine rupture is a serious condition that can jeopardize the health of both mothers and their unborn children. Rupture usually occurs in a uterus that has been scarred as a result of a previous cesarean delivery. There are relatively little data regarding the outcomes for mothers and neonates following rupture of an unscarred uterus, as this is such a rare complication. In the small number of reported cases of primary rupture, it was found to be associated with a perinatal mortality rate of 12% to 35% and a hysterectomy rate of 20% to 31%. The authors of this article designed their study to better understand the obstetric and neonatal characteristics surrounding primary rupture as well as its outcomes. The authors also evaluated uterine ruptures in scarred and unscarred uteruses and compared characteristics between these 2 groups.
Initial Preference for Labor Without Neuraxial Analgesia and Actual Use: Results from a National Survey in France
Authors: Kpéa L. , Bonnet M. , Ray C. , Prunet C. , Ducloy-Bouthors A. , Blondel B. 
Published: August 2016

(Anesth Analg. 2015;121:759–766)
Neuraxial analgesia is an effective labor pain relief option for pregnant women. It can refer to epidural, spinal, or combined spinal-epidural analgesia. In principle, neuraxial analgesia use should be the women’s choice. However, few studies have examined the association between women’s initial preferences for this pain relief option and its actual administration. In this study, authors studied factors associated with a woman’s preference to decline neuraxial analgesia, as well as the factors associated with the woman receiving neuraxial analgesia when she initially did not prefer it. Data were collected from a cross-section of the French 2010 National Perinatal Survey, which surveyed analgesia preference and provided information from medical records, interviews of women about their social/demographic characteristics, prenatal care, and pain management during labor, and questionnaires about maternity unit organization (535 maternity wards). Both univariate and multivariate analyses were conducted.
Pain Associated With Cesarean Delivery Skin Closure: A Randomized Controlled Trial
Authors: Mackeen A.D. , Khalifeh A. , Fleisher J. , Han C. , Leiby B. , Berghella V. 
Published: August 2016

(Obstet Gynecol. 2015;126:702–707)
Cesarean delivery is typically performed by a suprapubic low-transverse skin incision, which is closed with the placement of either a continuous absorbable suture or interrupted staples. Studies that have examined pain associated with suture closure compared with staple closure are varied and limited. The authors of the present study thereby compared patient-reported pain and pain medication use associated with these 2 forms of skin closure for cesarean delivery. This study was a secondary analysis of a prospective, multicenter, randomized clinical trial with 746 pregnant women undergoing either primary or repeat cesarean delivery. The primary outcome of the initial study was the incidence of wound complications associated with closure type; the primary analysis found that suture closure lowered the rate of wound complications.
Differences in Serum Human Chorionic Gonadotropin Rise in Early Pregnancy by Race and Value at Presentation
Authors: Barnhart Kurt T. , Guo Wensheng , Cary Mark S. , Morse Christopher B. , Chung Karine , Takacs Peter , Senapati Suneeta , Sammel Mary D. 
Published: August 2016

OBJECTIVE:
To assess whether variation in serum human chorionic gonadotropin (hCG) measures, used to assess early gestation viability, are associated with differences in clinical presentation and patient factors.

METHOD:
This retrospective cohort study included 285 women with first-trimester pain and bleeding and a pregnancy of unknown location for whom a normal intrauterine pregnancy was ultimately confirmed. Serial samples were collected at three U.S. sites and hCG changes were analyzed for differences by race, ethnicity, and clinical factors. A nonlinear, mixed-effects regression model was used assuming a random subject shift in the time axis.

RESULTS:
The hCG rise in symptomatic women with ongoing intrauterine pregnancy differs by patient factors and level at presentation. The 2-day minimum (first percentile) rise in hCG was faster when presenting hCG values were low and slower when presenting hCG value was high. African American women had a faster hCG rise (P<.001) compared with non–African American women. Variation in hCG curves was associated with prior miscarriage (P=.014), presentation of bleeding (P<.001), and pain (P=.002). For initial hCG values of less than 1,500, 1,500–3,000 and greater than 3,000 milli-international units/mL, the predicted 2-day minimal (first percentile) rise was 49%, 40%, and 33%, respectively.

CONCLUSION:
The rise of hCG levels in women with viable intrauterine pregnancies and symptoms of potential pregnancy failure varies significantly by initial value. Changes in hCG rise related to race should not affect clinical care. To limit interruption of a potential desired intrauterine pregnancy, a more conservative “cutoff” (slower rise) is needed when hCG values are high.

CLINICAL TRIAL REGISTRATION:
ClinicalTrials.gov, https://clinicaltrials.gov, NCT00194168.
Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain
Authors: Forte Brittany L. , Slosky Lauren M. , Zhang Hong , Arnold Moriah R. , Staatz William D. , Hay Meredith , Largent-Milnes Tally M. , Vanderah Todd W. 
Published: August 2016

Abstract
Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumor proliferation, further compromising patient quality of life. Angiotensin-(1-7) (Ang-(1-7)) binds and activates the Mas receptor (MasR). Angiotensin-(1-7)/MasR activation modulates inflammatory signaling after acute tissue insult, yet no studies have investigated whether Ang-(1-7)/MasR play a role in CIBP. We hypothesized that Ang-(1-7) inhibits CIBP by targeting MasR in a murine model of breast CIBP. 66.1 breast cancer cells were implanted into the femur of BALB/cAnNHsd mice as a model of CIBP. Spontaneous and evoked pain behaviors were assessed before and after acute and chronic administration of Ang-(1-7). Tissues were collected from animals for ex vivo analyses of MasR expression, tumor burden, and bone integrity. Cancer inoculation increased spontaneous pain behaviors by day 7 that were significantly reduced after a single injection of Ang-(1-7) and after sustained administration. Preadministration of A-779 a selective MasR antagonist prevented this reduction, whereas pretreatment with the AT2 antagonist had no effect; an AT1 antagonist enhanced the antinociceptive activity of Ang-(1-7) in CIBP. Repeated Ang-(1-7) administration did not significantly change tumor burden or bone remodeling. Data here suggest that Ang-(1-7)/MasR activation significantly attenuates CIBP, while lacking many side effects seen with opioids. Thus, Ang-(1-7) may be an alternative therapeutic strategy for the nearly 90% of patients with advanced-stage cancer who experience excruciating pain.
Low-grade Nonrhabdomyosarcoma Soft Tissue Sarcoma: What is Peculiar for Childhood
Authors: Fawzy Mohamed , Sedky Mohamed , ElZomor Hossam , El Sherbiny Magdy , Salama Emad , Mahdy Ahmed 
Published: August 2016

Background:
Nearly half of soft tissue sarcomas are nonrhabdomyosarcomas (NRSTSs). The low-grade (LG) form comprises a heterogenous group of diseases that rarely metastasize but are known for local recurrence.

Aim of the Study:
The aim of the study was to retrospectively evaluate pediatric LG-NRSTS with regard to demography, survival, and factors affecting outcome in Egyptian patients.

Patients and Methods:
The study reviewed 66 NRSTS patients who presented to the Pediatric Oncology Department, National Cancer Institute, Cairo University, between January 2008 and December 2013.

Results:
Out of the reviewed cases 32 patients had LG tumors and were eligible for analysis. The male to female ratio was 1:1 and the median age was 7.5 years (range, 1 mo to 18 y). Desmoid fibromatosis (N=18) showed frequent local recurrence and nearly half of this group was alive without disease. No recurrence of the disease occurred in the nonfibromatosis group (n=14) and all patients were alive and free of disease. The 5-year overall survival was 88% for the entire group of study patients versus 45% for event-free survival. Tumors >5 cm in diameter and fibromatosis histology subtype were associated with lower EFS.

Conclusions:
LG-NRSTS generally has good prognosis, with overall survival reaching 90%. However, aggressive fibromatosis usually runs a poorer course in the form of high incidence of local recurrence and lower survival rates. This needs to be further assessed in larger prospective studies including novel therapies in addition to the current conventional modalities.