bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels
Authors: Valente Pierluigi , Lignani Gabriele , Medrihan Lucian , Bosco Federica , Contestabile Andrea , Lippiello Pellegrino , Ferrea Enrico , Schachner Melitta , Benfenati Fabio , Giovedì Silvia , Baldelli Pietro 
Published: March 2016

ABSTRACT
L1 (also known as L1CAM) is a trans-membrane glycoprotein mediating neuron–neuron adhesion through homophilic and heterophilic interactions. Although experimental evidence has implicated L1 in axonal outgrowth, fasciculation and pathfinding, its contribution to voltage-gated Na+ channel function and membrane excitability has remained unknown. Here, we show that firing rate, single cell spiking frequency and Na+ current density are all reduced in hippocampal excitatory neurons from L1-deficient mice both in culture and in slices owing to an overall reduced membrane expression of Na+ channels. Remarkably, normal firing activity was restored when L1 was reintroduced into L1-deficient excitatory neurons, indicating that abnormal firing patterns are not related to developmental abnormalities, but are a direct consequence of L1 deletion. Moreover, L1 deficiency leads to impairment of action potential initiation, most likely due to the loss of the interaction of L1 with ankyrin G that produces the delocalization of Na+ channels at the axonal initial segment. We conclude that L1 contributes to functional expression and localization of Na+ channels to the neuronal plasma membrane, ensuring correct initiation of action potential and normal firing activity.
A Theoretical Study on the Mechanism and Kinetics of the Reaction of Methylthiyl Radical with Ozone
Authors: Mousavipour Seyed Hosein , Sadeghi Mojgan 
Published: March 2016

Abstract
Reaction mechanism and kinetics of gas-phase reaction of methylthiyl radical (CH3S (2A′)) with ozone (1A1) on the lowest doublet electronic state has been theoretically investigated. The composite method of G3MP2 was employed to obtain the optimized geometries of the stationary points and their energies. The most probable path for the title reaction is a barrier-less association channel to form a chemically activated intermediate of CH3SOOO*. The major products at lower temperatures are CH3SO and O2 while species like, CH3, SO, SO2, CH2S, CH2SOH, CH2SO, HO2, and OH are among the products of the probable secondary reactions. Direct hydrogen abstraction reaction of O3 with CH3S to form CH2S and HO3 is not an important channel at lower temperatures. Multichannel RRKM calculations along with the steady-state assumption for the energized intermediate and canonical variational transition-state theory have been used to predict the rate constants for the formation of the most important products. Rate constants for dissociation and isomerization of vibrationally “hot” CH3SO to form CH3 + SO and CH2SOH, respectively, are calculated by means of RRKM method, which are compared with those calculated for the vibrationally “cold” CH3SO. To comply with the previous experimental observations, the major product of the title reaction (CH3SO) should be produced as vibrationally “hot”.
Perineal herniation of an ileal neobladder following radical cystectomy and consecutive rectal resection for recurrent bladder carcinoma
Authors: Neumann PA , Mehdorn AS , Puehse G , Senninger N , Rijcken E 
Published: March 2016

Secondary perineal herniation of intraperitoneal contents represents a rare complication following procedures such as abdominoperineal rectal resection or cystectomy. We present a case of a perineal hernia formation with prolapse of an ileum neobladder following radical cystectomy and rectal resection for recurrent bladder cancer. Following consecutive resections in the anterior and posterior compartment of the lesser pelvis, the patient developed problems emptying his neobladder. Clinical examination and computed tomography revealed perineal herniation of his neobladder through the pelvic floor. Through a perineal approach, the hernial sac could be repositioned, and via a combination of absorbable and non-absorbable synthetic mesh grafts, the pelvic floor was stabilised. Follow-up review at one year after hernia fixation showed no signs of recurrence and no symptoms. In cases of extensive surgery in the lesser pelvis with associated weakness of the pelvic compartments, meshes should be considered for closure of the pelvic floor. Development of biological meshes with reduced risk of infection might be an interesting treatment option in these cases.
El empleo en las cooperativas de trabajo asociado: ¿derecho al trabajo o factor productivo?
Authors: Bengoetxea Alkorta Aitor 
Published: March 2016

Las sociedades capitalistas y las sociedades cooperativas muestran una naturaleza distinta. Las primeras giran en torno al capital que les da vida, y las segundas son personalistas; las personas cooperativistas tienen primacía con respecto al capital que aportan.La diferencia es evidente en el ámbito de las decisiones empresariales. En las sociedades capitalistas, los votos se distribuyen en proporción al capital aportado. En las cooperativas, impera el clásico principio de una persona, un voto.Las situaciones de crisis afectan por igual a ambos tipos de empresa. Sin embargo, la respuesta, con respecto al empleo, es diferente. En las sociedades de capital, el Derecho del Trabajo ofrece una variada gama de medidas para afrontar las situaciones de crisis, algunas de flexibilidad interna (movilidad funcional, reducción de jornada, suspensión contractual, etc.), y también el despido, una más de las posibilidades de la empresa.En las cooperativas, el Derecho Cooperativo deja claro que la baja obligatoria de las personas socias-trabajadoras (equivalente al despido), solo procederá como última ratio, cuando las medidas de flexibilidad interna se muestren insuficientes y sea necesario para garantizar la viabilidad futura de la empresa.Al tratar el despido como una medida supeditada a la obtención de beneficios, el Derecho del Trabajo trata el empleo como un mero factor productivo. El Derecho Cooperativo, sin embargo, al considerar la pérdida de empleo como último recurso, está preservando su carácter de derecho social.
The Chinese Sufi Wiqāyatullāh Ma Mingxin and the Construction of his Sanctity in Kitāb al-Jahrī
Authors: Sobieroj Florian 
Published: March 2016

Abstract
By contrast to the majority of the Muslim authors of Chinese origin who composed their literary works in the Chinese language, the authors of the Jahriyya Sufi order, a still active branch of the Naqshbandiyya network rooted mainly in the provinces of Gansu and Ningxia, have produced a small number of texts in the Arabic language and through this means they have recorded the conflict-ridden history of their menhuan and left behind a description of their belief-system. The main focus in this article lies on the sanctity (wilāya) of Ma Mingxin Wiqāyatullāh (died 1781), founder (daozu 道祖) of the Jahriyya order, as remembered and construed by his hagiographers in general and by the author of the Kitāb al-Jahrī, Manṣūr Ma Xuezhi (end of 19th and beginning of 20th c.), in particular: in their construction, Mingxin’s sanctity manifests itself in miracles, predictions, exorcisms and spiritual states. The text of the K. al-Jahrī which is the most comprehensive of the hagiographical writings of the Jahriyya as well as the other works of this group (e. g. Manāqib; Rashaḥāt) have all been transmitted in manuscript form within the Sufi order, they have been published in facsimile and been partly translated into Chinese. Hence a second focus has been laid on the codicology of the manuscript of the K. al-Jahrī, the basis of this study. Although the article mainly takes a codicological, philological and phenomenological approach to the subject of Mingxin´s sanctity, the historical background to his career as portrayed in the Chinese and Western-language studies has also been taken into consideration.
Numerical assessment of the reduction of specific absorption rate by adding high dielectric materials for fetus MRI at 3 T
Authors: Luo Minmin , Hu Can , Zhuang Yayun , Chen Wufan , Liu Feng , Xin Sherman Xuegang 
Published: March 2016

Abstract
The specific absorption rate (SAR) is an important issue to be considered in fetus MRI at 3 T due to the high radiofrequency energy deposited inside the body of pregnant woman. The high dielectric material (HDM) has shown its potential for enhancing B1 field and reducing SAR in MRI. The aim of this study is to assess the feasibility of SAR reduction by adding an HDM to the fetus MRI. The feasibility of SAR reduction is numerically assessed in this study, using a birdcage coil in transmission loaded with an electromagnetic pregnant woman model in the SEMCAD-EM solver. The HDMs with different geometric arrangements and dielectric constants are manually optimized. The

${B_1}^ + $
homogeneity is also considered while calculating the optimized fetus 10 g local SAR among different strategies in the application of HDM. The optimum maximum fetus 10 g local SAR was obtained as 2.25 W/kg, by using two conformal pads placed left and right with the dielectric constant to be 400, reduced by 24.75% compared to that without the HDM. It indicated that the SAR can be significantly reduced with strategic placement of the HDM and the use of HDM may provide a simple, effective and low-cost method for reducing the SAR for the fetus MRI at 3 T.
Molecular diagnosis and precision medicine in allergy management
Authors: Riccio Anna Maria , De Ferrari Laura , Chiappori Alessandra , Ledda Sabina , Passalacqua Giovanni , Melioli Giovanni , Canonica Giorgio Walter 
Published: March 2016

Abstract
Precision medicine (PM) can be defined as a structural model aimed at customizing healthcare, with medical decisions/products tailored on an individual patient at a highly detailed level. In this sense, allergy diagnostics based on molecular allergen components allows to accurately define the patient’s IgE repertoire. The availability of highly specialized singleplexed and multiplexed platforms support allergists with an advanced diagnostic armamentarium. The therapeutic intervention, driven by the standard diagnostic approach, but further supported by these innovative tools may result, for instance, in a more appropriate prescription of allergen immunotherapy (AIT). Also, the phenotyping of patients, which may have relevant effects on the treatment strategy, could be take advantage by the molecular allergy diagnosis.
Multiple-Instance Learning via an RBF Kernel-Based Extreme Learning Machine
Authors: Wang Jie , Cai Liangjian , Zhao Xin 
Published: March 2016

AbstractAs we are usually confronted with a large instance space for real-word data sets, it is significant to develop a useful and efficient multiple-instance learning (MIL) algorithm. MIL, where training data are prepared in the form of labeled bags rather than labeled instances, is a variant of supervised learning. This paper presents a novel MIL algorithm for an extreme learning machine called MI-ELM. A radial basis kernel extreme learning machine is adapted to approach the MIL problem using Hausdorff distance to measure the distance between the bags. The clusters in the hidden layer are composed of bags that are randomly generated. Because we do not need to tune the parameters for the hidden layer, MI-ELM can learn very fast. The experimental results on classifications and multiple-instance regression data sets demonstrate that the MI-ELM is useful and efficient as compared to the state-of-the-art algorithms.
The NKG2008 GPS campaign – final
transformation results and a new common Nordic
reference frame
Authors: Häkli P. , Lidberg M. , Jivall L. , Nørbech T. , Tangen O. , Weber M. , Pihlak P. , Aleksejenko I. , Paršeliunas E. 
Published: March 2016

Abstract
The NKG 2008 GPS campaign was carried out
in September 28 – October 4, 2008. The purpose was
to establish a common reference frame in the Nordic-
Baltic-Arctic region, and to improve and update the transformations
from the latest global ITRF reference frame
to the national ETRS89 realizations of the Nordic/Baltic
countries. Postglacial rebound in the Fennoscandian area
causes intraplate deformations up to about 10 mm/yr to
the Eurasian tectonic plate which need to be taken into account
in order to reach centimetre level accuracies in the
transformations.

We discuss some possible alternatives and present the
most applicable transformation strategy. The selected
transformation utilizes the de facto transformation recommended
by the EUREF but includes additional intraplate
corrections and a new common Nordic-Baltic reference
frame to serve the requirements of the Nordic/Baltic countries.
To correct for the intraplate deformations in the
Nordic-Baltic areawe have used the commonNordic deformation
model NKG RF03vel. The new common reference
frame, NKG ETRF00, was aligned to ETRF2000 at epoch
2000.0 in order to be close to the national ETRS89 realizations
and to coincide with the land uplift epoch of the national
height systems. We present here the realization of
the NKG ETRF00 and transformation formulae together
with the parameters to transform from global ITRF coordinates
to Nordic/Baltic realizations of the ETRS89.
Congenital diaphragmatic hernia – a Belgrade single center experience
Authors: Kalanj Jasna , Salevic Petar , Rsovac Snezana , Medjo Biljana , Antunovic Sanja Sindjic , Simic Dusica 
Published: March 2016

Abstract

Objective:
Though the outcome for children with congenital diaphragmal hernia (CDH) is improving, management of seriously compromised respiratory and cardiovascular function remains a great challenge. The aim of this study was to review a tertiary center experience in treating children with CDH.

Design:
Retrospective observational study from January 2005 to December 2014.

Setting:
Neonatal Intensive Care Unit (NICU) of University Children Hospital (UCH), Belgrade, Serbia.

Patients:
Children with CDH.

Results:
The CDH was diagnosed prenatally in 23% patients. An overall survival rate was 62%. Among those patients who underwent surgical repair 29 (90%) survived. There was statistically significant difference in survival rate between operated patients and total examined population (P=0.020). Prenatally diagnosed neonates with CDH had significantly lower survival rate comparing to those who were postnatally diagnosed (20% vs. 75%; P=0.002). Fatal outcome was more frequent in patients with small birth weight comparing to those with normal birth weight (67% vs. 30%; P=0.046).

Conclusions:
Our center survival rate for CDH is in accordance with other reported studies. Based on our experience there are potential points for further improvement. First, further increase of prenatal detection, planning for delivery, and coordinated transfer to tertiary institution, in order to avoid transfer of near death patients. Second, preoperative management in the NICU. This could be done by more uniform implementation of current consensual guidelines in monitoring, mechanical ventilation and circulatory support of these delicate patients, together with rationale use of newer therapeutic resources.
Crystal structure of catena-[aqua((4-carboxyphenyl)acetato-κO)(μ2-(4-carboxyphenyl)acetato-κ2
O:O′)bis(4,4′-ethene-1,2-diyldipyridine-κN)manganese(II)], C42H36N4O9Mn
Authors: Wei-Dong Yin , Gui-Lian Li 
Published: March 2016

Abstract
C42H36MnN4O9, monoclinic, P21/c (no. 14), a = 9.6432(10) Å, b = 8.8336(10) Å, c = 42.379(5) Å, β = 92.053(1)°, V = 3607.7(7) Å3, Z = 4, R
gt
(F) = 0.0434, wR
ref
(F
2
) = 0.0910, T = 296(2) K.
Crystal structure of 2-benzylisothiouronium tetraphenylborate, C32H31BN2S
Authors: Mostafa Gamal A. E. , Ghabbour Hazem A. , Abdel-Aziz Hatem A. 
Published: March 2016

Abstract
C32H31BN2S, monoclinic, P21/c (no. 14), a = 8.7214(4) Å, b = 15.4388(7) Å, c = 20.1249(10) Å, β = 92.176(2)°, V = 2707.8 (2) Å3, Z = 4, R
gt
(F) = 0.0586, wR
ref
(F
2
) = 0.1588, T = 296 K.
Crystal structure of 3-(4-hydroxy-3-methoxyphenyl)-N-phenylpropanamide, C16H17NO3
Authors: Mierina Inese , Gudelis Emilis , Stepanovs Dmitrijs , Jure Mara , Mishnev Anatoly , Kolympadi Maria , Marković Dean 
Published: March 2016

Abstract
C16H17NO3, orthorhombic, P212121 (no. 19), a = 7.9882 (2) Å, b = 11.4053 (3) Å, c = 16.2381 (5) Å, V = 1479.42 (7) Å3, Z = 4, R
gt
(F) = 0.0480, wR
ref
(F
2
) = 0.0991, T = 173 K.
The Effect of a Complex (3-week) Therapy on the Hip and Knee Joints in Obese Patients
Authors: Tóvári Anett , Hermann Mária , Tóvári Ferenc , Prisztóka Gyöngyvér , Kránicz János 
Published: March 2016

Abstract
Currently, overweight and obesity are the most widespread problems in life-style having a significant impact on everyday life, and thus, conduct of life. Further contributory problems may develop in patients with weight problems: deformities of the joints and skeleton (coxarthrosis and gonarthrosis), circulatory problems and arrhythmia. Overweight definitely has an effect on motion: some people are not involved in certain activities as it is impossible for them because of their weight problem. Thus, even more health problems are generated because of the overweight. The first question arising in discussing the actuality of this issue is what effect the applied therapy (massage, therapeutic exercises, electrotherapy and balneotherapy) has on the knee and hip joints of patients with weight problems hospitalised in our Institute for a 3-week complex therapy. Based on my prior hypothesis, positive changes are detected in a minimum percentage in the condition of overweight or obese patients. My hypothesis was that the range of flexion and extension of the hip and knee joints would improve compared to other movements. Based on the results of the studied population (n=30), my hypothesis seems to be proven. After the 3-week complex therapy of obese patients, positive changes were found in the prearranged assessments and tests, thereby improving the general health, life-style, life quality and mental status of the patients. After the end of the complex therapy, patients were provided life-style counselling and exercise schemes to be performed in their home to maintain the achieved health status.
Crystal structure of the alluaudite Ag2Mn3(VO4)3
Authors: Yahia Hamdi Ben , Shikano Masahiro , Essehli Rachid , Belharouak Ilias 
Published: March 2016

Abstract
The new compound Ag2Mn3(VO4)3 was synthesized by hydrothermal and solid state reaction routes, and its crystal structure was determined from single-crystal X-ray diffraction data. Ag2Mn3(VO4)3 crystallizes with a monoclinic symmetry, space group C2/c, with a=11.8968(11) Å, b=13.2057(13) Å, c=6.8132(7) Å, β=111.3166(15) (°) and V=997.16(17) Å3 (Z=4). Its crystal refinement yielded the residual factors R(F)=0.0249 and wR(F
2)=0.0704 for 95 parameters and 1029 independent reflections at a 3σ(I) level. Ag2Mn3(VO4)3 can be considered as a new member of the AA′MM′2(XO4)3 alluaudite family. The specific arrangement of M and M′ octahedral sites and of X tetrahedral sites gives rise to two different channels aligned along the crystallographic c-axis and containing the A and A′ sites. The A, A′, M, and X sites are fully occupied by Ag+, Mn2+, and V5+, respectively; whereas a Mn2+/Mn3+ mixture is observed in the M′ site.
Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines
Authors: Erenler Ramazan , Pabuccu Koksal , Yaglioglu Ayse Sahin , Demirtas Ibrahim , Gul Fatih 
Published: March 2016

Abstract
In this study, the effect of Mougeotia nummuloides and Spirulina major on Vero cells (African green monkey kidney), C6 cells (rat brain tumor cells) and HeLa cells (human uterus carcinoma) was investigated in vitro. The antiproliferative effect of the methanol extract of M. nummuloides and S. major compared with 5-fluorourasil (5-FU) and cisplatin was tested at various concentrations using the BrdU Cell Proliferation ELISA. Both M. nummuloides and S. major extracts significantly inhibited the proliferation of Vero, HeLa and C6 cancer cell lines with IC50 and IC75 values. The M. nummuloides extract exhibited higher activity than 5-FU and cisplatin on Vero and C6 cells at high concentrations. The S. major extract revealed better antifproliferative activity than standards against Vero cells at 500 μg/mL. The compounds of methanol extracts were determined by GC-MS after the silylation process. Trehalose, monostearin and 1-monopalmitin were detected as major products in the M. nummuloides extract where as in the S. major extract; monostearin, 1-monopalmitin and hexyl alcohol were the main constituents.
Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes
Authors: Giauque Christopher C , Bickel Sharon E 
Published: March 2016

Abstract
Accurate segregation of homologous chromosomes during meiosis depends on their ability to remain physically connected throughout prophase I. For homologs that achieve a crossover, sister chromatid cohesion distal to the chiasma keeps them attached until anaphase I. However, in Drosophila melanogaster wild-type oocytes, chromosome 4 never recombines, and the X chromosome fails to cross over in 6–10% of oocytes. Proper segregation of these achiasmate homologs relies on their pericentric heterochromatin-mediated association, but the mechanism(s) underlying this attachment remains poorly understood. Using an inducible RNA interference (RNAi) strategy combined with fluorescence in situ hybridization (FISH) to monitor centromere proximal association of the achiasmate FM7a/X homolog pair, we asked whether specific heterochromatin-associated proteins are required for the association and proper segregation of achiasmate homologs in Drosophila oocytes. When we knock down HP1a, H3K9 methytransferases, or the HP1a binding partner Piwi during mid-prophase, we observe significant disruption of pericentric heterochromatin-mediated association of FM7a/X homologs. Furthermore, for both HP1a and Piwi knockdown oocytes, transgenic coexpression of the corresponding wild-type protein is able to rescue RNAi-induced defects, but expression of a mutant protein with a single amino acid change that disrupts the HP1a-Piwi interaction is unable to do so. We show that Piwi is stably bound to numerous sites along the meiotic chromosomes, including centromere proximal regions. In addition, reduction of HP1a or Piwi during meiotic prophase induces a significant increase in FM7a/X segregation errors. We present a speculative model outlining how HP1a and Piwi could collaborate to keep achiasmate chromosomes associated in a homology-dependent manner.
Reaktualisasi Pengamalan Nilai Pancasila untuk Demokrasi Indonesia
Authors: Mutiani Mutiani 
Published: March 2016

Pancasila as an integral (comprehensively) is a solid supporting to the state established in Indonesia. Pancasila is maintained and developed with the aim to protect and develop the dignity and rights of all citizens of the nation to democracy in Indonesia. Posts in this article aims to explain how the urgency of re-actualization of Pancasila. As a method of this paper is literature study. The writer was conducting Pancasila in the context of political education in Indonesia emphasis on understanding the unity and integrity of the nation and the values listed in UUD 1945 with its main foundation of Pancasila. As the result, therefor, Pancasila is expected to realize the Good and Smart Citizenship, which, law-abiding citizens, to the literacy of citizens to political issues. Permalink/DOI: http://dx.doi.org/10.15408/sd.v2i2.2822