bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh perencanaan Pajak, Pertumbuhan Penjualan dan Ukuran Perusahaan terhadap Nilai Perusahaan
Authors: Yusuf Nur’aini , Fahdini Hera Triana 
Published: August 2024

Penelitian ini dilakukan dengan tujuan untuk menguji dan menganalisis pengaruh perencanaan pajak, pertumbuhan penjualan, dan ukuran perusahaan terhadap nilai perusahaan pada perusahaan sektor consumer non-cyclicals yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2018-2022. Penelitian ini menggunakan pendekatan kuantitatif. Teknik pengumpulan data dengan menggunakan teknik dokumentasi atau observasi tidak langsung. Penelitian ini termasuk dalam kategori penelitian sekunder, yaitu penelitian yang bertujuan untuk mengetahui pengaruh antara dua variabel. Populasi yang digunakan dalam penelitian ini yaitu perusahaan sektor consumer non-cyclicals yang Jurnal Sinergi Manajemen, Vol. 1, No.1, Februari 2024 (1-55) DOI: http://.................................... terdaftar di Bursa Efek Indonesia (BEI) dengan periode laporan tahun 2018-2022. Teknik pengambilan sampel pada penelitian ini menggunakan purposive sampling, dengan jumlah 140 data sampel dari 28 perusahaan yang memenuhi kriteria penelitian. Metode analisis yang digunakan dalam penelitian ini adalah analisis statistik deskriptif dengan uji asumsi klasik, uji koefisien determinasi dan uji parsial t-test. Dengan menggunakan analisis regresi linear berganda, pengujian data dibantu dengan software Microsoft Excel dan Statistic Eviews versi 9. Hasil dari penelitian ini adalah secara parsial perencanaan pajak dan pertumbuhan penjualan tidak berpengaruh terhadap nilai perusahaan, sementara ukuran perusahaan berpengaruh negatif terhadap nilai perusahaan. Namun secara simultan perencanaan pajak, pertumbuhan penjualan, dan ukuran perusahaan berpengaruh terhadap nilai perusahaan.
Memilih bertahan: bias kognitif pada korban kekerasan dalam pacaran
Authors: Firmansyah Muhammad Reza , Putra Anhar Dana , Rahmanawati Ainin 
Published: August 2024

Konflik yang tercipta dalam pacaran tidak selamanya dapat diatasi dengan baik, dalam beberapa kasus konflik kerap diatasi dengan agresi dan kekerasan, meskipun demikian masih terdapat individu yang memilih bertahan dalam hubungan walaupun sering mendapatkan tindak kekerasan oleh pasangannya, sehingga penelitian ini kemudian bertujuan untuk mengeksplorasi alasan seseorang bertahan dalam kekerasan pada hubungan pacaran, dengan menggunakan metode kualitatif penelitian ini menempatkan lima partisipan perempuan yang mengalami kekerasan dalam berpacaran baik secara fisik, verbal, psikologis, dan seksual. Hasil penelitian menunjukkan bahwa terdapat bias kognitif pada keputusan partisipan ketika memilih bertahan dalam kekerasan pada hubungan pacaran yang dijalani. Lebih lanjut lagi, penelitian ini berhasil mengidentifikasi jenis-jenis bias kognitif yang hadir pada partisipan, diantaranya; framing, emotional bias, illusion of control, loss of aversion dan regret of aversion, Khusus untuk framing hadir dan terkategorisasikan di semua partisipan penelitian. Bias kognitif yang hadir di masing-masing partisipan membuat tindak kekerasan resisten serta berulang sehingga partisipan menjadi tidak berdaya dan terjebak dalam hubungan yang tidak sehat.
Nucleolus
Authors: Shaw Peter J 
Published: November 2015

AbstractThe nucleolus is a nuclear substructure where the genes for three of the four ribosomal ribonucleic acids (rRNAs) are transcribed and where ribosomal subunits are assembled. Although the nucleolus has been intensively studied for many years, recent progress has been very rapid. We are beginning to understand how the biochemical processes carried out in the nucleolus relate to the observable structure. Recent observations of nucleolar proteins in living cells have shown that the nucleolus and its components are highly dynamic and that the observed structure is a steady state resulting from the relative nucleolar residence times of the various molecular components. There is much evidence that the nucleolus is also involved in many other roles, particularly in the biogenesis ofRNA(ribonucleic acid)‐containing complexes, in stress sensing and in the control of cellular activity and proliferation. There is considerable current interest in the nucleolus and ribosome biogenesis as targets for cancer therapy.Key ConceptsThe nucleolus is the clearest subnuclear structure in most eukaryotic cells and is the site of rDNA transcription and ribosome biosynthesis.Most nucleoli show three types of substructural components in standard thin section transmission electron microscopy: fibrillar centres (FC), dense fibrillar component (DFC) and granular component (GC).The interpretation of nucleolar ultrastructure in functional terms is still not fully understood, but rDNA transcription occurs within the DFC, and the subsequent stages of rRNA processing occur vectorially in enveloping layers as the transcripts move away from the transcription sites.Nucleoli share factors and, possibly, processes with other subnuclear structures, particularly Cajal bodies.Most nucleolar proteins are highly dynamic and diffuse freely through the nucleolus and nucleoplasm; ‘nucleolar’ proteins have a longer residence time in the nucleolus than in other parts of the nucleus, but these nucleolar residence times are in some cases as short as a few tens of seconds.The nucleolus is involved in many other nonconventional activities such as biogenesis of other RNP complexes, mRNA surveillance, and control of cell proliferation.The nucleolus is involved in stress sensing and has roles in triggering the p53 DNA damage response pathways.
A
cantharia
Authors: Decelle Johan , Not Fabrice 
Published: November 2015

Abstract

Acantharia are marine planktonic unicellular eukaryotes within the Radiolaria and currently encompass nearly 50 genera and 150 species. They are distributed worldwide from subsurface to deep waters and appear to be most numerous in oligotrophic surface waters. Their main distinctive features are an internal star‐shaped skeleton made of strontium sulfate mineral and an amoeboid cell that possesses multiple nuclei, extensive axopods and contractile myonemes. Acantharia feed on a large variety of prey, but some species are mixotrophs through symbiosis with intracellular eukaryotic microalgae, typically the haptophyte
Phaeocystis
. As part of their life cycle, some taxonomic groups form heavy cysts that rapidly sink to deep waters creating a biogeochemically relevant vertical flux of carbon, strontium and barium. Overall, Acantharia remain poorly studied, and our knowledge of their biology and ecology is still in its infancy.

Key Concepts

Acantharia are marine skeleton‐bearing planktonic protists that form a monophyletic taxon among radiolarians within the super‐group Rhizaria.

Acantharia have a complex cellular organisation (e.g. presence of myonemes and axopods) and exhibit an internal skeleton made of strontium sulfate (celestite), enriched in barium and composed of spicules that follow a specific geometric pattern (i.e. Müller's law).

There are nearly 50 genera and 150 species, distributed in several suborders, and most taxonomic criteria are based on skeleton morphology (e.g. central junction, form and shape of spicules).

Acantharia are ubiquitous in the world's oceans, and particularly abundant in surface oligotrophic waters at tropical and subtropical latitudes, but remain largely overlooked due to rapid skeleton dissolution upon cell death and inappropriate sampling methods.

Acantharia are primarily grazers with the use of their axopods, but several species are actually mixotrophs as they host intracellular symbiotic microalgae, making them significant primary consumers and producers in pelagic ecosystems.

Some acantharian species undergo encystment that is part of the reproduction process in deep waters, creating a biogeochemically significant vertical flux of carbon, nitrogen and strontium in the mesopelagic and bathypelagic zones.
Cholesterol Metabolism and Vascular Disease
Authors: Wainwright Patrick , Ryan Aidan , Olufadi Rasaq , Byrne Christopher D 
Published: November 2015

AbstractCholesterol is packaged into lipoprotein particles in the liver and intestine and transported to peripheral tissues for normal cellular function. Reverse cholesterol transport is the mechanism by which excess cholesterol is transported back to the liver and is facilitated by high‐density lipoproteins (HDLs). Increased plasma concentrations of cholesterol within the low‐density lipoprotein (LDL) molecule contribute to atherosclerotic vascular disease that commonly affects the coronary, cerebral and peripheral vascular circulation.There is now strong evidence to support the use of the statin class of drugs to decrease the risk of cardiovascular disease. Statins inhibit hepatic cholesterol synthesis, increase hepatic low‐density lipoprotein cholesterol (LDLc) receptor expression and consequently decrease plasma LDLc, to reduce the risk of myocardial infarction in people at widely varying risk of heart disease. At present, there is limited evidence to support the use of alternative classes of lipid‐lowering medications to reduce the risk of cardiovascular disease. Clinical trials are currently ongoing to assess the safety and efficacy of new types of medications to treat dyslipidaemias, the most promising of which are targeted against proprotein convertase subtilysin kexin 9 (PCSK9).Key ConceptsEndogenous and exogenous lipid pathways exist within the body.There are both inherited and acquired forms of hypercholesterolaemia.Low‐density lipoprotein cholesterol (LDLc) is associated with the development of coronary heart disease.Disordered lipid metabolism plays a crucial role in the development of atherosclerotic vascular disease.There is much clinical trial evidence now showing the effectiveness of certain classes of lipid‐lowering medication in lowering cholesterol levels and reducing the risk of cardiovascular disease.
Amyloid State of Proteins in Human Disease
Authors: Huang Lianqi , Huang Kun 
Published: November 2015

Abstract

Over 30 human amyloidoses, such as prion disease, Alzheimer's disease and Parkinson's disease, are characterised with the formation of amyloid plagues. Amyloid plagues are the products of protein aggregation, which begins with soluble amyloidogenic proteins into insoluble amyloid fibrils. Mounting evidences suggest that those aggregation processes are noxious to cells, during which the formation of oligomers is believed to be the most toxic species.
In vivo
, it has been proven that physiological factors have taken part in self‐defence line to reverse or alleviate the damages originated from aggregates. Moreover, therapeutic strategies targeting amyloid formation are also promising to alleviate human amyloidosis. In the present article, amyloid formation pathways, possible damages originated from different species of aggregates, physiological factors involved in self‐defence and therapeutic strategies targeting amyloid formation are summarised.

Key Concepts

The aggregation of amyloidogenic proteins plays critical roles in over 30 amyloidoses

Misfolded monomers, oligomers and fibrils are major species at different stages of aggregation

Oligomers are believed to be the most toxic species both
in vivo
and
in vitro

Physiological regulations against amyloid aggregations exist in healthy individuals

Targeting aggregates of amyloidogenic proteins at different stage could be a potential therapeutic approach to resolve amyloidosis
Stabilization of Palladium Nanoparticles on Nanodiamond–Graphene Core–Shell Supports for CO Oxidation
Authors: Zhang Liyun , Liu Hongyang , Huang Xing , Sun Xueping , Jiang Zheng , Schlögl Robert , Su Dangsheng 
Published: November 2015

AbstractNanodiamond–graphene core–shell materials have several unique properties compared with purely sp2‐bonded nanocarbons and perform remarkably well as metal‐free catalysts. In this work, we report that palladium nanoparticles supported on nanodiamond–graphene core–shell materials (Pd/ND@G) exhibit superior catalytic activity in CO oxidation compared to Pd NPs supported on an sp2‐bonded onion‐like carbon (Pd/OLC) material. Characterization revealed that the Pd NPs in Pd/ND@G have a special morphology with reduced crystallinity and are more stable towards sintering at high temperature than the Pd NPs in Pd/OLC. The electronic structure of Pd is changed in Pd/ND@G, resulting in weak CO chemisorption on the Pd NPs. Our work indicates that strong metal–support interactions can be achieved on a non‐reducible support, as exemplified for nanocarbon, by carefully tuning the surface structure of the support, thus providing a good example for designing a high‐performance nanostructured catalyst.
Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ‐Opioid Receptor
Authors: Okude Junya , Ueda Takumi , Kofuku Yutaka , Sato Motohiko , Nobuyama Naoyuki , Kondo Keita , Shiraishi Yutaro , Mizumura Takuya , Onishi Kento , Natsume Mei , Maeda Masahiro , Tsujishita Hideki , Kuranaga Takefumi , Inoue Masayuki , Shimada Ichio 
Published: November 2015

AbstractG‐protein‐coupled receptor (GPCR) ligands impart differing degrees of signaling in the G‐protein and arrestin pathways, in phenomena called “biased signaling”. However, the mechanism underlying the biased signaling of GPCRs is still unclear, although crystal structures of GPCRs bound to the G protein or arrestin are available. In this study, we observed the NMR signals from methionine residues of the μ‐opioid receptor (μOR) in the balanced‐ and biased‐ligand‐bound states. We found that the intracellular cavity of μOR exists in an equilibrium between closed and multiple open conformations with coupled conformational changes on the transmembrane helices 3, 5, 6, and 7, and that the population of each open conformation determines the G‐protein‐ and arrestin‐mediated signaling levels in each ligand‐bound state. These findings provide insight into the biased signaling of GPCRs and will be helpful for development of analgesics that stimulate μOR with reduced tolerance and dependence.
A Bioorthogonal Reaction of N‐Oxide and Boron Reagents
Authors: Kim Justin , Bertozzi Carolyn R. 
Published: November 2015

AbstractThe development of bioorthogonal reactions has classically focused on bond‐forming ligation reactions. In this report, we seek to expand the functional repertoire of such transformations by introducing a new bond‐cleaving reaction between N‐oxide and boron reagents. The reaction features a large dynamic range of reactivity, showcasing second‐order rate constants as high as 2.3×103 M−1 s−1 using diboron reaction partners. Diboron reagents display minimal cell toxicity at millimolar concentrations, penetrate cell membranes, and effectively reduce N‐oxides inside mammalian cells. This new bioorthogonal process based on miniscule components is thus well‐suited for activating molecules within cells under chemical control. Furthermore, we demonstrate that the metabolic diversity of nature enables the use of naturally occurring functional groups that display inherent biocompatibility alongside abiotic components for organism‐specific applications.
Stimuli‐Triggered Sol–Gel Transitions of Polypeptides Derived from α‐Amino Acid N‐Carboxyanhydride (NCA) Polymerizations
Authors: He Xun , Fan Jingwei , Wooley Karen L. 
Published: November 2015

AbstractThe past decade has witnessed significantly increased interest in the development of smart polypeptide‐based organo‐ and hydrogel systems with stimuli responsiveness, especially those that exhibit sol–gel phase‐transition properties, with an anticipation of their utility in the construction of adaptive materials, sensor designs, and controlled release systems, among other applications. Such developments have been facilitated by dramatic progress in controlled polymerizations of α‐amino acid N‐carboxyanhydrides (NCAs), together with advanced orthogonal functionalization techniques, which have enabled economical and practical syntheses of well‐defined polypeptides and peptide hybrid polymeric materials. One‐dimensional stacking of polypeptides or peptide aggregations in the forms of certain ordered conformations, such as α helices and β sheets, in combination with further physical or chemical cross‐linking, result in the construction of three‐dimensional matrices of polypeptide gel systems. The macroscopic sol–gel transitions, resulting from the construction or deconstruction of gel networks and the conformational changes between secondary structures, can be triggered by external stimuli, including environmental factors, electromagnetic fields, and (bio)chemical species. Herein, the most recent advances in polypeptide gel systems are described, covering synthetic strategies, gelation mechanisms, and stimuli‐triggered sol–gel transitions, with the aim of demonstrating the relationships between chemical compositions, supramolecular structures, and responsive properties of polypeptide‐based organo‐ and hydrogels.
On the Road to Resilience: The Help‐Seeking Experiences of Irish Emigrant Survivors of Institutional Abuse
Authors: Moore Jeff , Thornton Christine , Hughes Mary 
Published: November 2015

Understanding how survivors of complex trauma navigate towards resources can inform the design of interventions and health promotion strategies. However, there are little data on the resilience and help‐seeking experiences of this group or others who have experienced institutional abuse in childhood. This empirical study sets out to illustrate the help‐seeking experiences of Irish emigrant survivors of institutional childhood abuse (ICA). Twenty‐two survivors of ICA were purposefully recruited from community organisations in the UK and data were collected via semi‐structured interviews. As a result of negative initial help‐seeking experiences in Ireland, most participants engaged in long periods of self‐management and disclosed information about their childhood as part of a redress scheme in later life. Outside of this scheme, turning points, such as illness or family problems, and the needs of children were influential in seeking help. Peer support networks played an important role as a trusted signposting pathway towards formal interventions. Participants identified interpersonal barriers to formal help‐seeking as helping professionals' failure to share control, insensitivity to identity loss and literacy issues, and the lack of explicit boundaries. The paper concludes with a discussion about the implications for research and future practice.‘This empirical study sets out to illustrate the help‐seeking experiences of Irish emigrant survivors of institutional childhood abuse’Key Practitioner Messages:

Turning points, such as illness and bereavement, and the desire to provide for children, influence the help‐seeking of survivors of ICA.
Irish emigrant survivors of ICA cite failure to share control, insensitivity to identity loss, literacy issues and the lack of explicit boundaries as barriers to help‐seeking.
General awareness of ICA can help practitioners in low‐threshold services prevent against culturally insensitive practice.
Peer support networks can provide uniquely trusted signposting towards formal interventions.
The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii
Authors: Wang Mengyue , Xing Shihua , Luu Thithanhthuy , Fan Min , Li Xiaobo 
Published: November 2015

AbstractGrosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii (Swingle) C. Jeffrey, a medical plant endemic to China. In the present study, for the first time, the grosvenorine metabolism in an in vitro simulated human gastrointestinal tract (including artificial gastric juice, artificial intestinal juice and intestinal flora), as well as its pharmacological activities (including anti‐complement, antibacterial and antioxidant activities), was investigated. The results showed that grosvenorine was metabolized by human intestinal flora; its four metabolites were isolated by semi‐preparative HPLC and identified by NMR as kaempferitrin, afzelin, α‐rhamnoisorobin, and kaempferol. Further pharmacological evaluation showed that grosvenorine exhibited good antibacterial and antioxidant activities, with its metabolites possessing more potent activities. Although grosvenorine did not present obvious anticomplement activity, its metabolites showed interesting activities. This study revealed that intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.
Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin‐Induced Gastric Ulcer
Authors: Atalay Fadime , Odabasoglu Fehmi , Halici Mesut , Cakir Ahmet , Cadirci Elif , Aslan Ali , Aydin Berktas Ozlem , Kazaz Cavit 
Published: November 2015

AbstractTwo lichen metabolites, rhizonaldehyde (1) and rhizonyl alcohol (2), were isolated from the acetone extract of Lobaria pulmonaria by chromatographic methods, and their chemical structures were determined by UV/VIS, IR, and 1D‐ and 2D‐NMR spectroscopic methods. The gastroprotective and in vivo antioxidant activities of extracts of L. pulmonaria and its metabolites, 1 and 2, were investigated in indomethacin‐induced ulcer models in rats. The gastric lesions were significantly reduced by acetone, hexane, and CHCl3 extracts, with 75.3–41.5% inhibition. Rhizonyl alcohol (2) significantly reduced the gastric lesions with an inhibition rate of 84.6–42.8%, whereas rhizonaldehyde (1) significantly increased the gastric lesions. Antioxidant parameters and myeloperoxidase activities were also evaluated in the gastric tissues of the rats. Indomethacin caused oxidative stress, which resulted in lipid peroxidation in gastric tissues by decreasing the levels of the antioxidants as compared to healthy rat tissues. In contrast to indomethacin, all extracts and rhizonyl alcohol (2) caused a significant decrease in lipid peroxidation levels and an increase in antioxidant parameters, superoxide dismutase, glutathione peroxidase, and glutathione‐S‐transferase, and reduced glutathione in gastric tissues. The administration of rhizonyl alcohol (2) also resulted in a decrease in gastric myeloperoxidase activity increased by indomethacin. The gastroprotective effect of rhizonyl alcohol (2) can be attributed to its antioxidant properties and its suppressing effect on neutrophil infiltration into gastric tissues.
α‐Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358
Authors: Shan Wei‐Guang , Wu Zhao‐Ying , Pang Wei‐Wei , Ma Lie‐Feng , Ying You‐Min , Zhan Zha‐Jun 
Published: November 2015

AbstractOne new diketopiperazine alkaloid amauromine B (1), along with three known meroterpenoids, austalide B (2), austalides N and O (3 and 4), and two known steroids (5 and 6), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D‐NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X‐ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on α‐glucosidase. Amauromine B (1) and austalide N (3) exhibited more potent α‐glucosidase inhibitory activities than the positive control acarbose.