bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term consumption of sugar-sweetened beverage during the growth period promotes social aggression in adult mice with proinflammatory responses in the brain
Authors: Choi Jung-Yun , Park Mi-Na , Kim Chong-Su , Lee Young-Kwan , Choi Eun Young , Chun Woo Young , Shin Dong-Mi 
Published: April 2017

AbstractOverconsumption of sugar-sweetened beverages (SSBs) is known to be a key contributor to the obesity epidemic; however, its effects on behavioral changes are yet to be fully studied. In the present study, we examined the long-term effects of SSB on social aggression in mice. Three-week-old weaned mice started to drink either a 30 w/v% sucrose solution (S30), plain water (CT), or an aspartame solution with sweetness equivalent to the sucrose solution (A30) and continued to drink until they were 11-week-old adults. Aggressive behaviors were assessed by the resident-intruder test. We found that SSB significantly promoted social aggression, accompanied by heightened serum corticosterone and reduced body weight. To understand the underlying mechanism, we performed transcriptome analyses of brain. The profiles of mice on S30 were dramatically different from those on CT or A30. Transcriptional networks related to immunological function were significantly dysregulated by SSB. FACS analysis of mice on S30 revealed increased numbers of inflammatory cells in peripheral blood. Interestingly, the artificial sweetener failed to mimic the effects of sugar on social aggression and inflammatory responses. These results demonstrate that SSB promotes aggressive behaviors and provide evidence that sugar reduction strategies may be useful in efforts to prevent social aggression.
Ethnicity and anticoagulation management of hospitalized patients with atrial fibrillation in northwest China
Authors: Cheng Xinchun , Zhou Xianhui , Song Shifei , Wu Min , Baolatejiang Roza , Lu Yanmei , Li Yaodong , Zhang Wenhui , Lv Wenkui , Ye Yuanzheng , Zhou Qina , wang Hongli , Zhang Jianghua , Xing Qiang , Tang Baopeng 
Published: April 2017

AbstractThe therapeutic management and health challenges caused by atrial fibrillation (AF) differ between different groups. The purpose of this study was to investigate the clinical features of patients hospitalized with AF and to explore the use of anticoagulation treatments in Han and Uygur patients in Xinjiang, northwest China. Data were collected from a retrospective descriptive study involving patients hospitalized at 13 hospitals in Xinjiang, China from Jul 1, 2014 to Jun 31, 2015. Anticoagulation management was measured according to guideline-recommended risk scores. A total of 4,181 patients with AF were included (mean age 69.5 ± 11.7 years, 41.4% females; 71.5% Han, 28.5% Uygur). The prevalence of AF in Uygur individuals may occur earlier than in Han individuals (mean age 64.9 vs 71.3, P < 0.001). Most of the hospitalized patients with AF had a high risk of stroke (CHA2DS2-VASc score ≥2; 80.6% Han vs 73.7% Uygur, P < 0.05); this risk was especially high in elderly patients. In AF patients, the application of anticoagulants according to the guidelines is far from expected, and the underutilization of anticoagulants exists in both ethnic groups.
Novel Wavelet Real Time Analysis of Neurovascular Coupling in Neonatal Encephalopathy
Authors: Chalak Lina F. , Tian Fenghua , Adams-Huet Beverley , Vasil Diana , Laptook Abbot , Tarumi Takashi , Zhang Rong 
Published: April 2017

AbstractBirth asphyxia constitutes a major global public health burden for millions of infants, despite hypothermia therapy. There is a critical need for real time surrogate markers of therapeutic success, to aid in patient selection and/or modification of interventions in neonatal encephalopathy (NE). This is a proof of concept study aiming to quantify neurovascular coupling (NVC) using wavelet analysis of the dynamic coherence between amplitude-integrated electroencephalography (aEEG) and near-infrared spectroscopy in NE. NVC coupling is assessed by a wavelet metric estimation of percent time of coherence between NIRS SctO2 and aEEG for 78 hours after birth. An abnormal outcome was predefined by a Bayley III score <85 by 18–24 m. We observed high coherence, intact NVC, between the oscillations of SctO2 and aEEG in the frequency range of 0.00025–0.001 Hz in the non-encephalopathic newborns. NVC coherence was significantly decreased in encephalopathic newborns who were cooled vs. non-encephalopathic controls (median IQR 3[2–9] vs.36 [33–39]; p < 0.01), and was significantly lower in those with abnormal 24 months outcomes relative to those with normal outcomes (median IQR 2[1–3] vs 28[19–26], p = 0.04). Wavelet coherence analysis of neurovascular coupling in NE may identify infants at risk for abnormal outcomes.
Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Authors: Papageorgis Panagiotis , Polydorou Christiana , Mpekris Fotios , Voutouri Chrysovalantis , Agathokleous Eliana , Kapnissi-Christodoulou Constantina P. , Stylianopoulos Triantafyllos 
Published: April 2017

AbstractAccumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and nanotherapies. Stress alleviation treatment has been recently proposed to reduce mechanical stresses in order to decompress tumor vessels and improve perfusion and chemotherapy. However, it remains unclear if it improves the efficacy of nanomedicines, which present numerous advantages over traditional chemotherapeutic drugs. Furthermore, we need to identify safe and well-tolerated pharmaceutical agents that reduce stress levels and may be added to cancer patients’ treatment regimen. Here, we show mathematically and with a series of in vivo experiments that stress alleviation improves the delivery of drugs in a size-independent manner. Importantly, we propose the repurposing of tranilast, a clinically approved anti-fibrotic drug as stress-alleviating agent. Using two orthotopic mammary tumor models, we demonstrate that tranilast reduces mechanical stresses, decreases interstitial fluid pressure (IFP), improves tumor perfusion and significantly enhances the efficacy of different-sized drugs, doxorubicin, Abraxane and Doxil, by suppressing TGFβ signaling and expression of extracellular matrix components. Our findings strongly suggest that repurposing tranilast could be directly used as a promising strategy to enhance, not only chemotherapy, but also the efficacy of cancer nanomedicine.
A new strategy to measure intercellular adhesion forces in mature cell-cell contacts
Authors: Sancho Ana , Vandersmissen Ine , Craps Sander , Luttun Aernout , Groll Jürgen 
Published: April 2017

AbstractIntercellular adhesion plays a major role in tissue development and homeostasis. Yet, technologies to measure mature cell-cell contacts are not available. We introduce a methodology based on fluidic probe force microscopy to assess cell-cell adhesion forces after formation of mature intercellular contacts in cell monolayers. With this method we quantify that L929 fibroblasts exhibit negligible cell-cell adhesion in monolayers whereas human endothelial cells from the umbilical artery (HUAECs) exert strong intercellular adhesion forces per cell. We use a new in vitro model based on the overexpression of Muscle Segment Homeobox 1 (MSX1) to induce Endothelial-to-Mesenchymal Transition (EndMT), a process involved in cardiovascular development and disease. We reveal how intercellular adhesion forces in monolayer decrease significantly at an early stage of EndMT and we show that cells undergo stiffening and flattening at this stage. This new biomechanical insight complements and expands the established standard biomolecular analyses. Our study thus introduces a novel tool for the assessment of mature intercellular adhesion forces in a physiological setting that will be of relevance to biological processes in developmental biology, tissue regeneration and diseases like cancer and fibrosis.
An Elegant Analysis of White Spot Syndrome Virus Using a Graphene Oxide/Methylene Blue based Electrochemical Immunosensor Platform
Authors: Natarajan Anusha , Devi K. S. Shalini , Raja Sudhakaran , Senthil Kumar Annamalai 
Published: April 2017

AbstractWhite spot syndrome virus (WSSV) is a major devastating virus in aquaculture industry. A sensitive and selective diagnostic method for WSSV is a pressing need for the early detection and protection of the aquaculture farms. Herein, we first report, a simple electrochemical immunosensor based on methylene blue dye (MB) immobilized graphene oxide modified glassy carbon electrode (GCE/GO@MB) for selective, quick (35 ± 5 mins) and raw sample analysis of WSSV. The immunosensor was prepared by sequential modification of primary antibody, blocking agent (bovine serum album), antigen (as vp28 protein), secondary antibody coupled with horseradish peroxidase (Ab2-HRP) on the GCE/GO@MB. The modified electrode showed a well-defined redox peak at an equilibrium potential (E1/2), −0.4 V vs Ag/AgCl and mediated H2O2reduction reaction without any false positive result and dissolved oxygen interferences in pH 7 phosphate buffer solution. Under an optimal condition, constructed calibration plot was linear in a range of 1.36 × 10−3to 1.36 × 107copies μL−1of vp28. It is about four orders higher sensitive than that of the values observed with polymerase chain reaction (PCR) and western blot based WSSV detection techniques. Direct electrochemical immunosensing of WSSV in raw tissue samples were successfully demonstrated as a real sample system.
Prediction of the potential geographic distribution of the ectomycorrhizal mushroom Tricholoma matsutake under multiple climate change scenarios
Authors: Guo Yanlong , Li Xin , Zhao Zefang , Wei Haiyan , Gao Bei , Gu Wei 
Published: April 2017

AbstractEffective conservation and utilization strategies for natural biological resources require a clear understanding of the geographic distribution of the target species. Tricholoma matsutake is an ectomycorrhizal (ECM) mushroom with high ecological and economic value. In this study, the potential geographic distribution of T. matsutake under current conditions in China was simulated using MaxEnt software based on species presence data and 24 environmental variables. The future distributions of T. matsutake in the 2050s and 2070s were also projected under the RCP 8.5, RCP 6, RCP 4.5 and RCP 2.6 climate change emission scenarios described in the Special Report on Emissions Scenarios (SRES) by the Intergovernmental Panel on Climate Change (IPCC). The areas of marginally suitable, suitable and highly suitable habitats for T. matsutake in China were approximately 0.22 × 106 km2, 0.14 × 106 km2, and 0.11 × 106 km2, respectively. The model simulations indicated that the area of marginally suitable habitats would undergo a relatively small change under all four climate change scenarios; however, suitable habitats would significantly decrease, and highly suitable habitat would nearly disappear. Our results will be influential in the future ecological conservation and management of T. matsutake and can be used as a reference for studies on other ectomycorrhizal mushroom species.
Prologue: Reading Comprehension Is Not a Single Ability
Authors: Catts Hugh W. , Kamhi Alan G. 
Published: April 2017

Purpose
In this initial article of the clinical forum on reading comprehension, we argue that reading comprehension is not a single ability that can be assessed by one or more general reading measures or taught by a small set of strategies or approaches.

Method
We present evidence for a multidimensional view of reading comprehension that demonstrates how it varies as a function of reader ability, text, and task. The implications of this view for instruction of reading comprehension are considered.

Conclusion
Reading comprehension is best conceptualized with a multidimensional model. The multidimensionality of reading comprehension means that instruction will be more effective when tailored to student performance with specific texts and tasks.
Antibiotics Prescriptions in the Neonatal Intensive Care Unit: How to Overcome Everyday Challenges
Authors: Mozzo E. , Mardegan V. , Trafojer U. , Lago P. , Salvadori S. , Baraldi E. , Giaquinto C. , Donà D. 
Published: April 2017

AbstractAntimicrobial prescriptions in neonatal intensive care units (NICUs) represent a point of concern for the emergence of MDROs and for morbidity associated with prolonged antibiotic exposure (e.g., invasive candidiasis, necrotizing enterocolitis, and late-onset sepsis). Antimicrobial stewardship programs (ASPs) have shown to be a valuable tool for the prevention of resistance with the goals of optimizing clinical outcomes while decreasing unnecessary prescribing. The most frequent ASP strategies include the correct collection and interpretation of microbiological specimens, prescription of the narrowest-spectrum antibiotic appropriate for a particular case, and de-escalation or discontinuation of therapy in defined situations. A robust ASP requires everyday multidisciplinary collaboration between ID physicians, neonatologist, clinical pharmacists, clinical microbiologists, infection control professionals, hospital epidemiologists, and information services specialists. Education and clinical pathways (e.g., sepsis or surgical prophylaxis pathways) are an excellent starting point if followed by proactive interventions such as prospective audits and feedback and formulary restriction with prior antimicrobial authorization. The current review outlines the problems faced in NICU antimicrobial prescribing and presents various solutions from the literature.
Aging as a motive for literary retranslation
Authors: Van Poucke Piet 
Published: April 2017

AbstractOne of the concepts that is regularly referred to in studies on retranslation, but has not yet been extensively investigated or operationalized, is the (alleged) aging of (literary) translations. While the assumption that every generation deserves its own translation of canonical literary works is taken for granted, particularly by non-academic critics of literary (re)translations, this notion does not seem to be as prevalent in academia. In this article, I review the scholarly literature on retranslation in order to determine how the concept of aging has been defined and described in translation studies so far. The findings of this survey will subsequently be tested out with a number of case studies on literary retranslation, allowing us to determine the relative importance of the concept and define its different aspects. Finally, I present the first results of an empirical pilot study on aging in literary translation, and will suggest several lines for further investigation that would allow translation studies to further operationalize the concept for future, more comprehensive and systematic analyses of aging in all its different (linguistic, translational, and cultural) aspects.
Effect of electropulsing-assisted turning process on AISI 5120 cementation steel
Authors: Xu Z. , Wang H. , Sun Z. , Ye Y. , Tang G. 
Published: April 2017

Electropulsing was used to aid in the cutting process of the AISI 5120 cementation steel. Electropulsing is found, on the one hand, to significantly decrease the main cutting force and reduce the tool wear and, on the other hand, to largely improve the surface quality and surface hardness of the specimen. Electropulsing showed remarkable improvement in plastic deformation ability and cutting properties by inducing lubrication property. This phenomenon can be explained by the enhanced mobility of dislocations that resulted from the electroplastic effect and Joule heating. This paper is part of a themed issue on Materials in External Fields.
Ancient ecstatic theater and Analytical Psychology: creating space for Dionysus
Authors: Evans Romero Constance 
Published: April 2017

ABSTRACTThis paper explores links between the theatrical aspect of the Dionysian archetype and Analytical Psychology. It looks at some of the Dionysian elements in Jung’s published work and follows up with a brief exploration into how some of the potentially generative aspects of the archetype continue to be suspect in current clinical practice. Plutarch’s historic anecdote about the first actor, Thespis, and his dialogue with the Athenian Magistrate, Solon, will provide a focus with which to explore Dionysian elements within the Individuation process. A final section includes a short case history illustrating Dionysian elements unfolding in the theater of Jungian analysis.
miRCat2: accurate prediction of plant and animal microRNAs from next-generation sequencing datasets
Authors: Paicu Claudia , Mohorianu Irina , Stocks Matthew , Xu Ping , Coince Aurore , Billmeier Martina , Dalmay Tamas , Moulton Vincent , Moxon Simon 
Published: April 2017

Abstract

Motivation
MicroRNAs are a class of ∼21–22 nt small RNAs which are excised from a stable hairpin-like secondary structure. They have important gene regulatory functions and are involved in many pathways including developmental timing, organogenesis and development in eukaryotes. There are several computational tools for miRNA detection from next-generation sequencing datasets. However, many of these tools suffer from high false positive and false negative rates. Here we present a novel miRNA prediction algorithm, miRCat2. miRCat2 incorporates a new entropy-based approach to detect miRNA loci, which is designed to cope with the high sequencing depth of current next-generation sequencing datasets. It has a user-friendly interface and produces graphical representations of the hairpin structure and plots depicting the alignment of sequences on the secondary structure.

Results
We test miRCat2 on a number of animal and plant datasets and present a comparative analysis with miRCat, miRDeep2, miRPlant and miReap. We also use mutants in the miRNA biogenesis pathway to evaluate the predictions of these tools. Results indicate that miRCat2 has an improved accuracy compared with other methods tested. Moreover, miRCat2 predicts several new miRNAs that are differentially expressed in wild-type versus mutants in the miRNA biogenesis pathway.

Availability and Implementation
miRCat2 is part of the UEA small RNA Workbench and is freely available from http://srna-workbench.cmp.uea.ac.uk/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Using Lean Management to Reduce Emergency Department Length of Stay for Medicine Admissions
Authors: Allaudeen Nazima , Vashi Anita , Breckenridge Julia S. , Haji-Sheikhi Farnoosh , Wagner Sarah , Posley Keith A. , Asch Steven M. 
Published: April 2017

Background:
The practice of boarding admitted patients in the emergency department (ED) carries negative operational, clinical, and patient satisfaction consequences. Lean tools have been used to improve ED workflow. Interventions focused on reducing ED length of stay (LOS) for admitted patients are less explored.

Objective:
To evaluate a Lean-based initiative to reduce ED LOS for medicine admissions.

Design, Setting, Patients:
Prospective quality improvement initiative performed at a single university-affiliated Department of Veterans Affairs (VA) medical center from February 2013 to February 2016.

Intervention:
We performed a Lean-based multidisciplinary initiative beginning with a rapid process improvement workshop to evaluate current processes, identify root causes of delays, and develop countermeasures. Frontline staff developed standard work for each phase of the ED stay. Units developed a daily management system to reinforce, evaluate, and refine standard work.

Measurements:
The primary outcome was the change in ED LOS for medicine admissions pre- and postintervention. ED LOS at the intervention site was compared with other similar VA facilities as controls over the same time period using a difference-in-differences approach.

Results:
ED LOS for medicine admissions reduced 26.4%, from 8.7 to 6.4 hours. Difference-in-differences analysis showed that ED LOS for combined medicine and surgical admissions decreased from 6.7 to 6.0 hours (−0.7 hours, P = .003) at the intervention site compared with no change (5.6 hours, P = .2) at the control sites.

Conclusions:
We utilized Lean management to significantly reduce ED LOS for medicine admissions. Specifically, the development and management of standard work were key to sustaining these results.
Evidence-Based Practice Standard Care for Acute Pain Management in Adults With Sickle Cell Disease in an Urgent Care Center
Authors: Kim Sunghee , Brathwaite Ron , Kim Ook 
Published: April 2017

Background:
Vaso-occlusive episodes (VOEs) with sickle cell disease (SCD) require opioid treatment. Despite evidence to support rapid pain management within 30 minutes, care for these patients does not consistently meet this benchmark. This quality improvement study sought to decrease the first analgesic administration time, increase patient satisfaction, and expedite patient flow.

Methods:
A prospective pre-/postevaluation design was used to evaluate outcomes with patients 18 years or older with VOEs in an urgent care (UC) center after implementation of evidence-based practice standard care (EBPSC). A pre- and postevaluation survey of SCD patients' satisfaction with care and analogous surveys of the UC team to assess awareness of EBPSC were used. A retrospective review of the electronic medical records of patients with VOEs compared mean waiting time from triage to the first analgesic administration and the mean length of stay (LOS) over 6 months.

Results:
Implementing EBPSC decreased the mean time of the first analgesic administration (P = .001), significantly increased patient satisfaction (P = .002), and decreased the mean LOS (P = .010).

Conclusion:
Implementing EBPSC is a crucial step for improving the management of VOEs and creating a positive patient experience. The intervention enhances the quality of care for the SCD population in a UC center.
The nature and value of terroir products
Authors: Charters Stephen , Spielmann Nathalie , Babin Barry J. 
Published: April 2017

PurposeThe aim of this paper is to consider place as a value proposition, in the context of Resource-Advantage Theory, by analysing the concept of terroir, including its antecedents and consequences.Design/methodology/approachThe authors conceptually analyse the role of place in marketing by contrasting terroir to three other approaches: “in the style of […]”; “made in […]” and Protected Designations of Origin. They explore the impact of terroir on a range of products, offering a series of terroir value propositions.FindingsVersus other place links, terroir offers a more specific Resource-Advantage, operating at environmental, philosophical and commercial levels. It offers a unique form of value to both consumers (e.g. identity, authenticity, cultural rootedness) and producers (e.g. irreproducibility, potential legal protection).Research limitations/implicationsPropositions address the antecedents and consequences of the terroir designation, the impact of consumer engagement, perceived authenticity and the added value offered to other regional goods. Additionally, how terroir may form a barrier to market entry, the relationship it has with the territorial brand, whether it offers greater product longevity and how it can be used as leverage for other related place-based brands and tourism are examined.Originality/valueThis is the first paper to address terroir as a marketing concept and to situate it within other forms of place marketing. It provides a definition, outlines the ways in which terroir creates value and provides a research agenda for future engagement with the concept.