bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naturalistic sleep tracking in a longitudinal cohort: how long is long enough?
Authors: Goparaju Balaji , de Palma Glen , Bianchi Matt T. 
Published: October 2024

AbstractBackgroundDespite broad interest in the health implications of sleep duration, traditional measurements via polysomnography or actigraphy are often limited to one or a few nights per person. Given the potential variability of sleep duration over time, inferential uncertainty remains an important issue for relatively short observation windows.MethodsWe describe potential limitations of shorter duration sleep tracking by sub-sampling from longer-term observation windows, using a combined approach of simulated data from known distributions, in addition to real-world data (30-365 nights) from over 35,000 participants who provided informed consent to participate in the Apple Heart and Movement Study and elected to contribute sleep data to the study.ResultsSimulations demonstrate that the magnitude of deviation from truth, defined using all available observations per individual, as well as the presence and direction of bias, depended on the sub-sample size, the type of simulated distribution (Gaussian versus skewed), and the summary statistics of interest, such as central tendency (mean, median) and dispersion (standard deviation (SD), interquartile range). For example, the SD computed from n=7 observations from a simulated normal distribution (7+1 hours) showed a median 6.7% under-estimation bias (IQR 24% under- to 14.7% over-estimation). Real-world sleep duration data, when under-sampled and compared to longer observations within-participant, showed similar SD bias at 7 nights, and similar convergence rates approaching the true value (based on 90 nights) as longitdunal sample number increases. Shapiro-Wilk tests for normality and log-normality show that 64% of simulated log-normal (skew) distributions fail to reject normality at n=7 samples, while real-world sleep duration data most commonly failed both normality and log-normality tests. Finally, simulated cohorts with sleep durations of 7+1 hours mixed with a subset of 6+1 hours sleepers showed that a random single-night observation of “short sleep” (6 hours) is more likely from random variation of a 7-hour sleeper, than from an actual 6-hour sleeper. Extending the observation to n=7 nights mitigates this mis-classification risk.ConclusionThe results of simulations and empiric data patterns suggests that longer duration tracking provides important and tangible benefits to reduce bias and uncertainty in sleep health research that historically relies on small observation windows.
Deep sleep homeostatic response to naturalistic sleep loss
Authors: Goparaju Balaji , Ravindran Sharon , Bianchi Matt T. 
Published: October 2024

AbstractIntroductionInvestigations of sleep homeostasis often involve tightly controlled experimental sleep deprivation in service of understanding mechanistic physiology. The extent to which the deep sleep response to recent sleep loss occurs in naturalistic settings remains under-studied. We tested the hypothesis that a homeostatic increase in deep sleep occurs on the night following occasional short duration nights that arise in naturalistic settings.MethodsWe analyzed sleep staging data in participants who provided informed consent to participate in the Apple Heart and Movement Study and elected to contribute sleep data. The analysis group included n=44,564 participants with at least 30 nights of sleep staging data from Apple Watch, from November 2022 to May 2023, totaling over 5.3 million nights.ResultsShort nights of sleep that were >=2 hours shorter than each participant’s median sleep duration occurred at least once in 92.9% of the cohort, most often in isolation (<7% of instances were consecutive short nights), and with a median duration of just over 4 hours. We observed that the amount of deep sleep increased on the subsequent night in proportion to the amount of sleep loss on the preceding short night, in a dose response manner for short night definitions ranging from 30 minutes to >=3 hours below the within-participant median sleep duration. Focusing on short nights that were at least 2 hours below the median duration, we found that 58.8% of participants showed any increase in subsequent deep sleep, with a median increase of 12% (absolute increase of 5 minutes). In addition, the variability in deep sleep after short nights markedly increased in a dose response manner. The deep sleep homeostatic response showed little correlation to sleep duration, timing, consistency, or sleep stages, but was inversely correlated with deep sleep latency (Spearman R = -0.28).ConclusionThe results provide evidence for homeostatic responses in a real-world setting. Although the deep sleep rebound amounts are modest, naturalistic short nights are a milder perturbation compared to experimental deprivation, and reactive behaviors potentially impacting sleep physiology are uncontrolled. The marked increase in variability of deep sleep amount after short nights may reflect unmeasured reactive behaviors such as caffeine or napping, which exert opposing pressures on deep sleep compared to the homeostat. The findings illustrate the utility of longitudinal sleep tracking to assess real-world correlates of sleep phenomenology established in controlled experimental settings.
Rewired gene interactions during development of serially homologous appendages in male and femaleDrosophila
Authors: Ridgway Amber M. , Figueras Jimenez Javier , Nunes Maria D. S. , McGregor Alistair P. 
Published: October 2024

AbstractDrosophilagenitalia and legs are considered to be serially homologous appendages derived from a ventral appendage ‘ground state’ shaped by different Hox inputs. Despite their shared origin, there has been relatively little comparison between the downstream gene regulatory networks and how they may differently pattern and shape these appendages. In the pre-tarsal region of the developing leg and antennae ofDrosophila, a combination of the transcription factors C15, Lim1 homeobox 1 (Lim1), and Al (Aristaless) are required for the development of the leg tarsal claws and antennal aristae. However, the roles and interactions of these factors in genital development, and their relationship with other leg-patterning genes, remained unexplored. Here, we investigated the expression and function of C15, Lim1, and Al in the development of male and female terminalia (genitalia and analia). We found that C15 plays distinct roles in the different sexes, repressing male clasper bristle formation while promoting bristle development in the female epiproct. Notably, unlike in the antennal and leg discs, C15, Lim1, and Al are not all co-expressed in any anal or genital structures in either sex, indicating that the interactions among these factors have diverged across serially homologous appendages. Nevertheless, we inferred regulatory interactions between C15 and other factors, includingbric a brac 2andDistal-less,reflecting similarities between leg and genital development consistent with their homology. Finally, we identified a male-specific enhancer ofC15, likely regulated by the Hox geneAbdominal-B(Abd-B), which is active in male claspers but not in the female terminalia, legs or antennae. ThisC15enhancer modularity may underpin tissue-specific regulatory logic, presumably programmed by distinct Hox inputs such as Abd-B in the genitalia, and could contribute to the diversification of serially homologous ventral appendages.
In vivofunctional profiling and structural characterisation of the humanGlp1rA316T variant
Authors: Eid Liliane El , Deane-Alder Kieran , Rujan Roxana-Maria , Mariam Zamara , Oqua Affiong I. , Manchanda Yusman , Belousoff Matthew J. , Bernardino de la Serna Jorge , Sloop Kyle W. , Rutter Guy A. , Montoya Alex , Withers Dominic J. , Millership Steven J. , Bouzakri Karim , Jones Ben , Reynolds Christopher A. , Sexton Patrick M. , Wootten Denise , Deganutti Giuseppe , Tomas Alejandra 
Published: October 2024

AbstractGlucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective therapies for type 2 diabetes (T2D) and obesity, yet patient responses are variable. Variation in the humanGlp1rgene might be directly linked to therapeutic responses. A naturally occurring missense variant, A316T, protects against T2D and cardiovascular disease. Here, we have generated and characterised a humanGlp1rA316T mouse model. HumanGlp1rA316T/A316Tmice displayed lower fasting blood glucoseversuswildtype littermates, even under metabolic stress, and exhibited alterations in islet cytoarchitecture and α/β-cell identity under a high-fat, high-sucrose diet. This was however associated with blunted responses to GLP-1RAsin vivo. Further investigations in rodent and human β-cell models demonstrated that humanGlp1rA316T exhibits characteristics of constitutive activation but dampened GLP-1RA responses. Results are further supported by cryo-EM analyses and molecular dynamics simulations of GLP-1R A316T structure, collectively demonstrating that the A316T variant governs basal GLP-1R activity and pharmacological responses to GLP-1R-targeting therapies.TeaserTheGlp1rA316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responsesin vivo.
An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes
Authors: Mossadeq Layla El , Bellutti Laura , Borgne Rémi Le , Canman Julie C. , Pintard Lionel , Verbavatz Jean-Marc , Askjaer Peter , Dumont Julien 
Published: October 2024

ABSTRACTAt the end of cell division, the nuclear envelope reassembles around the decondensing chromosomes. Female meiosis culminates in two consecutive cell divisions of the oocyte, meiosis I and II, which are separated by a brief transition phase known as interkinesis. Due to the absence of chromosome decondensation and the suppression of genome replication during interkinesis, it has been widely assumed that the nuclear envelope does not reassemble between meiosis I and II. By analyzing interkinesis inC. elegansoocytes, we instead show that an atypical structure made of two lipid bilayers, which we termed the interkinetic envelope, surrounds the surface of the segregating chromosomes. The interkinetic envelope shares common features with the nuclear envelope but also exhibits specific characteristics that distinguish it, including its lack of continuity with the endoplasmic reticulum, unique protein composition, assembly mechanism, and function in chromosome segregation. These distinct attributes collectively define the interkinetic envelope as a unique and specialized structure that has been previously overlooked.
High-risk human papillomavirus cervical infection prevalence in France, 2020-2023: a nationwide, large-scale, and spatially resolved retrospective study comparing opportunistic and organised screening
Authors: Supplisson Olivier , Tessandier Nicolas , Roussel Mathilde , Haim-Boukobza Stéphanie , Burrel Sonia , Sofonea Mircea T. , Alizon Samuel 
Published: October 2024

AbstractBackgroundIn France, cervical cancer screening for females aged 30 to 65 primarily targets high-risk human papillomavirus (HPV) infections using DNA tests (‘HR HPV test’).AimThe primary goal was to map the prevalence of cervical infections caused by HPV16 and/or 18, or by any of 12 other carcinogenic genotypes (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68). The secondary goal was to compare prevalence estimates obtained from tests conducted after spontaneous medical visits (‘opportunistic screening’) or as part of the national screening programme (‘organised screening’).MethodsThe analytic sample contained 362,963 results of HR HPV tests collected, between 2020 and 2023, in metropolitan France. A full hierarchical Bayesian model was used to compute spatially resolved prevalence maps at the postcode level.ResultsAmong samples from organised and opportunistic screening, 2.9% and 3.8% were positive for HPV16 and/or 18, respectively. For other genotypes, these percentages were 6.9% and 9.4%, respectively.During the last week of the study period, among females aged 30, opportunistic screening was associated with a greater HPV infection prevalence for HPV16 and/or 18 (other genotypes) in 97.2 [72.9,100.0]% (99.9 [99.3,100.0]%) of postcodes. The probability of this percentage being lower among females aged 66 was below 95% for both genotype groups.After correcting for this effect, a pronounced northwest/southeast gradient in HR HPV infection prevalence was found across France, for both genotype groups, with some hotspots located at the border with Spain and Italy and Switzerland.ConclusionOpportunistic screening is associated with systematic inflation in HR HPV infection prevalence.
Sec14L6 is a PS and PI4P transporter that promotes lipid droplet formation
Authors: Zhou Tiantian , Du Yuanjiao , Hu Xuewen , Ji Wei-Ke 
Published: October 2024

AbstractLipid droplets (LDs) are evolutionarily conserved organelles that are crucial for cellular metabolism. LD biogenesis and growth occurs in the ER and requires the supply of phospholipid from the ER, but the molecular basis is largely unclear. Here, we have identified Sec14L6, a unique protein of the Sec14 family, as a PS/PI4P transporter required for LD biogenesis. Sec14L6 knockout (KO) greatly reduces the number of LDs that can be rescued by wild-type rather than lipid transfer-defective Sec14L6 mutants. We found that Sec14L6 directly interacts with ACSL3, and that this interaction facilitates targeting of Sec14L6 to LDs and activates the PS transfer activity of Sec14L6in vitro. We also identified PGRMC1, an ER membrane protein, as an adaptor that recruits Sec14L6 to the ER. Furthermore, depletion of Sec14L6 impairs differentiation of adipose-derived mesenchymal stem cells. Together, our study suggests that Sec14L6 transports PS and/or PI4P between the ER and LDs to promote LD formation.
First observation of single photons in a CRESST detector and new dark matter exclusion limits
Authors: Angloher G. , Banik S. , Benato G. , Bento A. , Bertolini A. , Breier R. , Bucci C. , Burkhart J. , Canonica L. , D’Addabbo A. , Di Lorenzo S. , Einfalt L. , Erb A. , Feilitzsch F. v. , Fichtinger S. , Fuchs D. , Garai A. , Ghete V. M. , Gorla P. , Guillaumon P. V. , Gupta S. , Hauff D. , Ješkovský M. , Jochum J. , Kaznacheeva M. , Kinast A. , Kluck H. , Kraus H. , Kuckuk S. , Langenkämper A. , Mancuso M. , Marini L. , Mauri B. , Meyer L. , Mokina V. , Olmi M. , Ortmann T. , Pagliarone C. , Pattavina L. , Petricca F. , Potzel W. , Povinec P. , Pröbst F. , Pucci F. , Reindl F. , Rothe J. , Schäffner K. , Schieck J. , Schönert S. , Schwertner C. , Stahlberg M. , Stodolsky L. , Strandhagen C. , Strauss R. , Usherov I. , Wagner F. , Wagner V. , Zema V. ,   CRESST Collaboration
Published: October 2024

The main goal of the CRESST-III experiment is the direct detection of dark matter particles via their scattering off target nuclei in cryogenic detectors. In this work we present the results of a silicon-on-sapphire (SOS) detector with a mass of 0.6 g and an energy threshold of (6.7±0.2)  eV with a baseline energy resolution of (1.0±0.2)  eV. This allowed for a calibration via the detection of single luminescence photons in the eV-range, which could be observed in CRESST for the first time. We present new exclusion limits on the spin-independent and spin-dependent dark matter-nucleon cross section that extend to dark matter particle masses of less than 100  MeV/c2.

Published by the American Physical Society
2024
An expert system based decision-making framework for benchmarking industry in sustainable manufacturing
Authors: Mandal Madhab Chandra , Mondal Nripen , Ray Amitava 
Published: October 2024

PurposeThe purpose of this study is to evaluate and enhance sustainable manufacturing practices across various industries, focusing on environmental, economic and social dimensions, to promote a comprehensive understanding and implementation of sustainability, thereby improving overall industry performance and fostering long-term ecological and economic health.Design/methodology/approachThe study uses multi-criteria decision-making-multivariate analysis technique to examine sustainable manufacturing practices (SMPs) in the Indian manufacturing sector. It identifies 11 SMP criteria through literature review and expert recommendations. Data are collected through questionnaires, expert committees and interviews. The study focuses on four key industries: automobile, steel, textile and plastic. Techniques like principal component analysis (PCA), technique for order preference by similarity to ideal solution (TOPSIS) and complex proportional assessment (COPRAS) are used to rank and assess performance.FindingsThe Indian automobile industry has shown the most effective SMPs compared to steel, textile and plastic sectors. The automobile sector is the benchmark for sustainable measures, emphasizing the importance of green practices for environmental, social and economic performance. Recommendations extend beyond the automobile sector to cement, electronics and construction.Practical implicationsThe research emphasizes the importance of SMPs across various industries, focusing on economic, environmental and social considerations. It advocates for a holistic approach that enhances resource efficiency and minimizes ecological footprint.Originality/valueThe study uses ranking methods like PCA-integrated TOPSIS and COPRAS to evaluate performance in different industries, focusing on the benchmarked automobile sector. The research offers valuable insights and advocates for the widespread adoption of sustainable policies beyond the studied sectors.
Ethnic diversity on boards and its interaction with gender diversity: should they have any beneficial effects on HRM?
Authors: Li Ji , Jiang Wanxing , Liu Mengli , Huang Jun , Tao Xiaolong 
Published: October 2024

PurposeThis study deals with the issue of how ethnic diversity on boards in a given firm may influence its performance in human resource management (HRM). Moreover, the study also tests the interaction between ethnic diversity and gender diversity and examines their joint effect on HRM.Design/methodology/approachBased on prior research, we predict that, with increasing demographic diversity in organizations today, ethnic diversity on boards should have a positive effect on HRM. Moreover, gender diversity, as a most visible dimension of demographic diversity, should have both a direct positive effect and an indirect moderating effect on the relationship between ethnic diversity and HRM. Hierarchical regression analysis was conducted to test the hypotheses.FindingsOur data analyses show empirical evidence supporting our predictions. First, our study shows that employer–employee relationship can be influenced by ethnic diversity on boards. Second, the foregoing analyses highlight the importance of considering the interaction between different dimensions of demographic diversity, such as that between ethnic and gender diversity. With a higher level of gender diversity on boards, the positive effect of ethnic diversity on HRM can become more salient.Originality/valueThis research tests the benefits of ethnic diversity on boards for improving firms’ performance in HRM, thus making a contribution by helping to understand the effects of ethnic diversity in a more comprehensive way. We also document the beneficial moderating effects of gender diversity on boards for the first time.
Towards sustainable development: financial inclusion and women’s economic empowerment in India
Authors: Showkat Mohsin , Nagina Razia , Nori Usha 
Published: October 2024

Purpose
This study aims to examine the relationship between financial inclusion and economic empowerment of women, recognising that empowering women is not just an issue of equity and fairness but also an essential prerequisite for achieving sustainable development.

Design/methodology/approach
This research used a survey method to gather data from the female population in northern India. The quantitative analysis was conducted using structural equation modelling with Smart PLS 4 software, based on the theoretical framework of economic empowerment theory.

Findings
The results demonstrated a notable association between financial inclusion and women’s economic empowerment. The presence of active participation in financial services appears to contribute significantly to variations in women’s earnings, savings and accumulation of assets.

Originality/value
This study contributes to guiding development agencies and policymakers by highlighting the importance of expanding financial services tailored to women and advocating inclusive banking.
Calibration of a dual-robot collaborative system for drilling tasks on spacecraft core cabins
Authors: Lu Xiaoyu , Tian Wei , Lu Xingdao , Li Bo , Liao Wenhe 
Published: October 2024

Purpose
This study aims to propose a calibration method to enhance the positioning accuracy in dual-robot collaborative operations, aiming to address the challenge of drilling hole spacing errors in spacecraft core cabin brackets that require an accuracy of less than 0.5 mm.

Design/methodology/approach
Initially, the cooperative error of dual robots is defined. Subsequently, an integrated model is constructed that encompasses the kinematic model errors of the dual robots, as well as the establishment errors of the base and tool frames. A calibration method for optimizing the cooperative accuracy of dual robots is proposed.

Findings
The application of the proposed method satisfies the collaborative drilling requirements for the spacecraft core cabin. The average cooperative positioning error of the dual robots was reduced from 0.507 to 0.156 mm, with the maximum value and standard deviation decreasing from 1.020 and 0.202 mm to 0.603 and 0.097 mm, respectively. Drilling experiments conducted on a core cabin simulator demonstrated that after calibration, the maximum hole spacing error was reduced from 1.219 to 0.403 mm, with all spacing errors falling below the 0.5 mm threshold, thus meeting the requirements.

Originality/value
This paper addresses the drilling accuracy requirements for spacecraft core cabins by using a calibration method to reduce the cooperative error of dual robots. The algorithm has been validated through experiments using ER 220 robots, confirming its effectiveness in fulfilling the drilling task requirements.
Climate risk perception and corporate ESG performance: evidence from China
Authors: Li Menghan 
Published: October 2024

PurposeThis study examines the impact of climate risk perception on corporate environmental, social and governance (ESG) performance from a microfirm perspective.Design/methodology/approachUsing a sample of Chinese listed companies from 2009 to 2021, we constructed corporate climate risk perception indicators based on the Management Discussion and Analysis (MD&A) in the annual reports of the companies, and analyzed it using ordinary least squares regression.FindingsThe results show that climate risk perception improves corporate ESG performance by encouraging green innovation. Heterogeneity analysis suggests that the greater the magnitude of climate risk shocks to the firms, the stronger the risk coping ability and the weaker the environmental regulation, the more pronounced the improvement of climate risk perception on corporate ESG performance. Furthermore, economic consequence analysis shows that the enhancement effect of climate risk perception on corporate ESG performance contributes to increasing corporate value.Originality/valueThis study emphasizes the significance of corporate climate risk perception in enhancing ESG performance. It provides a theoretical basis for enterprises to respond to climate risk and sustainable development.