bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling the plastic deformation of Ti6Al4V under dynamic loading
Authors: Kakogiannis D. , Coghe F. , Verleysen P. , Louar M. A. , Rabet L. 
Published: January 2016

In this paper, a multiscale numerical method is presented with the aim to model the response of a Ti6Al4V sheet under explosive forming. The numerical modelling focuses on the accurate definition of the plastic deformation of the Ti6Al4V specimens based on the texture of the material. The viscoplastic self-consistent polycrystal model code (VPSC) is used as a link between macroscopic response and the underlying microstructure taking into account the viscoplastic deformation of the specimen. Comparison is made with experimental results. The Cazacu–Barlat (CB06) material model is used because of its capability to describe the yielding asymmetry between tension and compression and to take into account the anisotropic behaviour of the sheet. The study focuses on the evaluation of the material model parameters and on how these affect the structural response of the Ti6Al4V specimens under explosive loading. This paper is part of a Themed Issue on Euromech 570: Interface-dominated materials.
Study on controlling inclusions and total oxygen of high-carbon steel
Authors: Ma W. J. , Lui G. L. , Gao P. , Luo Y. Z. , Li H. B. , Chen B. 
Published: January 2016

The inclusion type, and the relationship between inclusions and the total oxygen, and the ways of decreasing the inclusion count and controlling the inclusion evolution are studied. The results are shown as follows: when the slag composition is controlled in an appropriate range, the slag melting point is low and the ability of deoxidation and inclusion absorption are good. The total oxygen is proportional to the count of 0–6 μm inclusions in the unit area. The mixing of the ladle and the removal of inclusion were promoted by optimising the ladle field. By Mg or Ca treatment, the size of Al2O3 inclusions can be reduced. But the large size CaO inclusions may be brought into steel by the Ca treatment. This paper is part of a Themed Issue on Recent developments in bearing steels.
Chlorogenic acid ameliorates intestinal mitochondrial injury by increasing antioxidant effects and activity of respiratory complexes
Authors: Zhou Yan , Zhou Lili , Ruan Zheng , Mi Shumei , Jiang Min , Li Xiaolan , Wu Xin , Deng Zeyuan , Yin Yulong 
Published: January 2016

Abstract
Dietary polyphenols are thought to be beneficial for human health by acting as antioxidants. Chlorogenic acid (CGA) is abundant in plant-based foods as an ester of caffeic acid and quinic acid. In this study, we investigated the effects of CGA on mitochondrial protection. Our results demonstrated that pretreatment with CGA ameliorated the intestinal mitochondrial injury induced by H2O2; membrane potential was increased, mitochondrial swelling, levels of reactive oxygen species, contents of 8-hydroxy-2-deoxyguanosine, and cytochrome c released were decreased. The beneficial effects of CGA were accompanied by an increase in antioxidant and respiratory-chain complex I, IV, and V activities. In trinitrobenzene-sulfonic acid-induced colitic rats indicated that CGA supplementation improved mitochondria ultrastructure and decreased mitochondrial injury. Our results suggest a promising role for CGA as a mitochondria-targeted antioxidant in combating intestinal oxidative injury. Daily intake of diets containing CGA, such as coffee and honeysuckle, may be useful for prevention of intestinal diseases.
Syntheses and biological activities of deoxy-d-allose fatty acid ester analogs
Authors: Chowdhury Md Tazul Islam , Ando Hikaru , Yanagita Ryo C , Kawanami Yasuhiro 
Published: January 2016

Abstract
We describe the syntheses of three different deoxy-D-allose analogs [2-deoxy-D-allose (2-DOAll), 1,2-dideoxy-D-allose (1,2-DOAll), and 1,2-didehydro-1,2-dideoxy-D-allose (1,2-DHAll)] and their fatty acid esters via regioselective lipase-catalyzed transesterification. Among them, 2-DOAll and its decanoate (2-DOAll-C10) showed higher inhibitory activity on plant growth, which is similar to D-allose (All) and its decanoate (All-C10). Bioassay results of deoxy-All-C10 on four plant species suggest that the hydroxy group at the C-1 position might be important showing growth inhibitory activity. In addition, co-addition of gibberellin (GA3) with 1,2-DHAll-C10 and 2-DOAll-C10 recovered plant growth, suggesting that they might mainly inhibit biosynthesis of gibberellin.
Allyl isothiocyanate suppresses the proteolytic activation of sterol regulatory element-binding proteins and de novo fatty acid and cholesterol synthesis
Authors: Miyata Shingo , Inoue Jun , Shimizu Makoto , Sato Ryuichiro 
Published: January 2016

Abstract
Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of genes involved in fatty acid and cholesterol synthesis. In this study, we used a stable cell line that expresses a luciferase reporter gene driven by an SRE-containing fatty acid synthase promoter to identify allyl isothiocyanate (AITC), one of the major isothiocyanates in cruciferous vegetables, as a novel SREBP inactivator. We found that AITC downregulated the proteolytic processing of SREBPs and the expression of their target genes in human hepatoma Huh-7 cells. Furthermore, AITC reduced the de novo synthesis of both fatty acids and cholesterol. Our results indicate a novel physiological function of AITC in lipid metabolism regulation.
Program models and semi-public environments
Authors: Grossi Davide , van der Hoek Wiebe , Moyzes Christos , Wooldridge Michael 
Published: January 2016

AbstractWe develop a logic for reasoning about semi-public environments , i.e. environments in which a process is executing, and where agents in the environment have partial and potentially different views of the process. Previous work on this problem illustrated that it was problematic to obtain both an adequate semantic model and a language for reasoning about semi-public environments. We here use program models for representing the changes that occur during the execution of a program. These models serve both as syntactic objects and as semantic models, and are a modification of action models in Dynamic Epistemic Logic, in the sense that they allow for ontic change (i.e. change in the world or state). We show how program models can elegantly capture a notion of observation of the environment. The use of these models resolves several difficulties identified in earlier work, and admit a much simpler treatment than was possible in previous work on semi-public environments.
Skin cancer: non-melanoma
Authors: Damian Diona L. , Scolyer Richard A. , Stevens Graham , Menzies Alexander M. , Thompson John F. 
Published: January 2016

Non-melanoma skin cancer (NMSC) is the most common malignancy in fair-skinned populations. In Australia, NMSC is four times as common as all other cancers combined with an incidence of ~1000 per 100 000 person-years. The vast majority of NMSC are basal cell carcinomas (BCCs), which rarely metastasize, or squamous cell carcinomas (SCCs), which do have metastatic potential, especially in immune-suppressed individuals. Because of their high frequency in the general population, and particularly in older people, NMSCs are likely to occur in many general oncology patients. Skin cancer risk can be additionally increased in oncology patients as a result of disease-induced immune suppression (e.g., non-Hodgkin’s lymphoma) or by a range of cancer treatments including iatrogenic immune suppression, radiation therapy, arsenic, and BRAF inhibitors. Interestingly, chronic stress suppresses skin immune responses and increases susceptibility to UV-induced SCC in murine models.
Brief Report: Macrophage Activation in HIV-2–Infected Patients Is Less Affected by Antiretroviral Treatment—sCD163 in HIV-1, HIV-2, and HIV-1/2 Dually Infected Patients
Authors: Hønge Bo L. , Andersen Morten N. , Jespersen Sanne , Medina Candida , Correira Faustino G. , Jakobsen Martin R. , Laursen Alex , Erikstrup Christian , Møller Holger J. , Wejse Christian ,   for the Bissau HIV cohort study group
Published: January 2016

Abstract:
The course of disease among HIV-2, HIV-1, and HIV-1/2 dually infected patients is different. We investigated the macrophage activation marker soluble CD163 (sCD163) dynamics in 212 HIV-1, HIV-2, and HIV-1/2 dually infected patients. There were no differences in sCD163 levels at baseline or during follow-up without antiretroviral therapy (ART). At follow-up on ART, median sCD163 levels were decreased for HIV-1–infected patients (P < 0.001), but not among HIV-2 (P = 0.093) or HIV-1/2 dually infected patients (P = 0.145). The larger decrease in sCD163 levels among HIV-1–infected patients during ART may indicate an HIV type–dependent differential effect of ART on macrophage activation during HIV infection.
DAVID: An open-source platform for real-time emotional speech transformation: With 25 applications in the behavioral sciences
Authors: Rachman Laura , Liuni Marco , Arias Pablo , Lind Andreas , Johansson Petter , Hall Lars , Richardson Daniel , Watanabe Katsumi , Dubal Stéphanie , Aucouturier Jean-Julien 
Published: January 2016

AbstractWe present an open-source software platform that transforms the emotions expressed by speech signals using audio effects like pitch shifting, inflection, vibrato, and filtering. The emotional transformations can be applied to any audio file, but can also run in real-time (with less than 20-millisecond latency), using live input from a microphone. We anticipate that this tool will be useful for the study of emotions in psychology and neuroscience, because it enables a high level of control over the acoustical and emotional content of experimental stimuli in a variety of laboratory situations, including real-time social situations. We present here results of a series of validation experiments showing that transformed emotions are recognized at above-chance levels in the French, English, Swedish and Japanese languages, with a naturalness comparable to natural speech. Then, we provide a list of twenty-five experimental ideas applying this new tool to important topics in the behavioral sciences.
Signatures of positive selection and local adaptation to urbanization in white-footed mice (Peromyscus leucopus)
Authors: Harris Stephen E. , Munshi-South Jason 
Published: January 2016

ABSTRACTUrbanization significantly alters natural ecosystems and has accelerated globally. Urban wildlife populations are often highly fragmented by human infrastructure, and isolated populations may adapt in response to local urban pressures. However, relatively few studies have identified genomic signatures of adaptation in urban animals. We used a landscape genomics approach to examine signatures of selection in urban populations of white-footed mice (Peromyscus leucopus) in New York City. We analyzed 154,770 SNPs identified from transcriptome data from 48P. leucopusindividuals from three urban and three rural populations, and used outlier tests to identify evidence of urban adaptation. We accounted for demography by simulating a neutral SNP dataset under an inferred demographic history as a null model for outlier analysis. We also tested whether candidate genes were associated with environmental variables related to urbanization. In total, we detected 381 outlier loci and after stringent filtering, identified and annotated 19 candidate loci. Many of the candidate genes were involved in metabolic processes, and have well-established roles in metabolizing lipids and carbohydrates. Our results indicate that white-footed mice in NYC are adapting at the biomolecular level to local selective pressures in urban habitats. Annotation of outlier loci suggest selection is acting on metabolic pathways in urban populations, likely related to novel diets in cities that differ from diets in less disturbed areas.
Error sensitivity analysis of a microassembly system with coaxial alignment function
Authors: Ye Xin , Liu Pan , Zhang Zhijing , Shao Chao , Li Yan 
Published: January 2016

Purpose
– The purpose of this paper is to analyze the sensitivity of the motion error parameters in microassembly process, thereby improving the assembly accuracy. The motion errors of the precision motion stages directly affect the final assembly quality after the machine visual alignment.

Design/methodology/approach
– This paper presents the error parameters of the in-house microassembly system with coaxial alignment function, builds the error transfer model by the multi-body system theory, analyzes the error sensitivity on the sensitive direction using the Sobol method, which was based on variance, and then gets the ones which made a great degree of influence. Before the sensitivity analyzing, parts of the error sources have been measured to obtain their distribution ranges.

Findings
– The results of the sensitivity analysis by the Sobol method, which was based on variance, are coincident with the theoretical analysis. Besides, the results provide a reference for the error compensation in control process, for the selection of the precision motion stages and for the installation index of the motion stages of the assembly system with coaxial alignment.

Originality/value
– This kind of error sensitivity analysis method is of great significance for improving the assembly accuracy after visual system positioning, and increasing efficiency from the initial motion stage selection to final error compensation for designers. It is suitable for general precision motion systems be of multi-degree of freedom, for the method of modeling, measuring and analyzing used in this paper are all universal and applicative.
An efficient evolutionary method of assembly sequence planning for shipbuilding industry
Authors: Iwankowicz Remigiusz Romuald 
Published: January 2016

Purpose
– The purpose of this paper is to develop the method of generating assembly sequences, which can be used in the shipbuilding industry. The method must take into account the assumptions specific for assembly processes of large-size steel ship hulls, among others, a large number of connections, multi-stage and parallel assembly, set priority relations between connections.

Design/methodology/approach
– The assembly sequence is presented as a directed acyclic graph, whose vertices are mutually uniquely assigned to connections on a hull structure. The minimization of the number of unmet priority precedence of performing connections has been proposed as a criterion of optimization. The genetic algorithm has been proposed as a method to solve problems.

Findings
– The proposed method allows to model the acyclic assembly process of welded structures and find solutions minimizing the objective function even for very complex problems. Because of this, the method has a chance to be used in shipbuilding.

Research limitations/implications
– Mathematical formulation of priority assumptions is quite laborious. The possibility of partial automation of this process should be considered. Due to the complexity of the problem, a relatively simplified objective function has been proposed. In assembling a hull, additional criteria should be taken into account. It is the direction of further research.

Practical implications
– The method can be successfully used in shipbuilding and in planning the production of other steel welded structures, among others, tanks, components of bridges, offshore structures. Examples of calculations were performed on an actual structure of a hull fragment.

Originality/value
– A new way of coding the acyclic serial-parallel sequence was designed. The proposed method allows to analyse the sequence using the graph theory. Original, two-part crossover and mutation operators for assembling sequence were proposed.
A novel assembly simulation method based on semantics and geometric constraint
Authors: Wang Pan , Li Yuan , Yu Lin , Zhang Jie , Xu Zhijia 
Published: January 2016

Purpose
– The purpose of this paper is to provide a novel assembly simulation method to reduce the repetitive and tedious assembly simulation work. Currently, assembly simulation is always carried out by human–computer interaction, which is a time-consuming and tedious work. The most important reason for this problem is that the assembly simulation is a mapping between human intent and movements of models; at the same time, assembly information is transferred from semantic level to geometric level. However, some essential assembly information is lost during the transfer, and it must be accomplished through manual definition. To address the issue, a novel assembly simulation method is proposed in this paper based on semantics and geometric constraint.

Design/methodology/approach
– First, an assembly operation semantic model is put forward to integrate and manage the semantic information of assembly, and some rules for modeling are generalized. Second, method for transferring assembly information from semantic level to geometric level is presented by dividing assembly operation into a set of simulation actions and providing some rules for this division. Then, a geometric constraint-based calculation method is proposed to obtain the essential parameters of each simulation action. Finally, cases are studied to demonstrate the effectiveness of the method.

Findings
– Results show that laborious work would be reduced, and the redundant human participation would be avoided in assembly simulation.

Practical implications
– It has the potential and possibility to change the current pattern of assembly simulation.

Originality/value
– A novel assembly simulation method based on semantics and geometric constraint is presented to make assembly simulation more convenient and faster.
Design for assembly and disassembly for remanufacturing
Authors: Soh SL , Ong S K , Nee A Y C 
Published: January 2016

Purpose– This research aims to propose a methodology for a systematic, concurrent consideration of design for assembly (DFA) and disassembly guidelines and constraints for product remanufacturing. The methodology provides a holistic approach to design product from the remanufacturing perspective.Design/methodology/approach– The proposed methodology incorporates parts’ integration assessment and evaluation of part complexity and accessibility taking into consideration both DFA and design-for-disassembly (DFD) guidelines and constraints. Metrics for accessibility and complexity in retrieving the remanufacturable cores from a product are evaluated to determine the best possible disassembly route considering the practical constraints which an operator might face during disassembly. As there could be more than one feasible disassembly route to retrieve a core during remanufacturing, a disassembly evaluation is conducted to determine the optimal path after combination of the parts of the assembly.Findings– In remanufacturing, products need to be disassembled and re-assembled again. Conflicts exist between DFA and DFD. The proposed methodology serves to address these conflicting issues. The proposed methodology eases a designer’s effort systematically to incorporate both aspects, by incorporating practical consideration to determine an optimal disassembly sequence through integrating the handling aspect of assembly complexity assessment with the U-Rating disassembly effort indexing scheme to provide a quantitative evaluation of disassembly complexity, as disassembly still largely requires human effort.Research limitations/implications– Future research will explore methods to improve the user interface with features to determine feasible disassembly routes of a product automatically. This will relieve the effort of the product designer to a great extent.Originality/value– This paper proposes a methodology for a systematic, concurrent consideration of DFA and DFD to provide a holistic approach to product design from the remanufacturing perspective to ease the designer’s task. Practical considerations will be made to determine the optimal disassembly route of the product. DFD will only be required to be applied to the selected disassembly route to minimize conflicts with DFA.
Geometric tolerance analysis through Jacobian model for rigid assemblies with translational deviations
Authors: Polini Wilma , Corrado Andrea 
Published: January 2016

Purpose– The purpose of this paper is to carry out a tolerance analysis with geometric tolerances by means of the Jacobian model. Tolerance analysis is an important task to design and to manufacture high-precision mechanical assemblies; it has received considerable attention by the literature. The Jacobian model is one of the methods proposed by the literature for tolerance analysis. The Jacobian model cannot deal with geometric tolerances for mechanical assemblies. The geometric tolerances may not be neglected for assemblies, as they significantly influence their functional requirements.Design/methodology/approach– This paper presents how it is possible to deal with geometric tolerances when a tolerance analysis is carried out by means of a Jacobian model for a 2D and 3D assemblies for which the geometric tolerances applied to the components involve only translational deviations. The three proposed approaches modify the expression of the stack-up function to overcome the shortage of Jacobian model that the geometric error cannot be processed.Findings– The proposed approach has been applied to a case study. The results of the case study show how, when a statistical approach is implemented, the Jacobian model with the three developed methods gives results very similar to those due to other models of the literature, such as vector loop and variational.Research limitations/implications– In particular, the proposed approach may be applied only when the applied geometrical tolerances involve translational variations in 3D assemblies.Practical implications– Tolerance analysis is a valid tool to foresee geometric interferences among the components of an assembly before getting the physical assembly. It involves a decrease of the manufacturing costs.Originality/value– The original contribution of the paper is due to three methods to make a Jacobian model able to consider form and geometric deviations.
Human-inspired motion model of upper-limb with fast response and learning ability – a promising direction for robot system and control
Authors: Qiao Hong , Li Chuan , Yin Peijie , Wu Wei , Liu Zhi-Yong 
Published: January 2016

Purpose
– Human movement system is a Multi-DOF, redundant, complex and nonlinear system formed by coordinating combination of neural system, bones, muscles and joints, which is robust and has fast response and learning ability. Imitating human movement system can improve robustness, fast response and learning ability of the robots.

Design/methodology/approach
– In this paper, we propose a new motion model based on the human motion pathway, especially the information propagation mechanism between the cerebellum and spinal cord.

Findings
– The proposed motion model proves to have fast response and learning ability through experiments, which matches the features of human motion.

Originality/value
– The proposed model in this paper introduces the habitual theory in kinesiology and neuroscience into robot control, and improves robustness, fast response and learning ability of the robots. This paper proves that introduction of neuroscience has an important guiding significance for precise and adaptive robot control, such as assembly automation.