bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ideas and the changing relationship between states and markets in social policy: A review essay
Authors: Béland Daniel , Mandelkern Ronen 
Published: October 2024

AbstractThis review essay takes stock of the recent literature about the role of ideas in social policy, with a particular focus on a key issue in social policy research: the changing interactions between states and markets over time. Specifically, our aim is to examine how the ideational literature discusses and explains prominent contemporary social policy evolutions: the rise of social investment and the financialization and technocratization of the welfare state. This is done based on the scholarship on state/market interactions and the role of ideas in social policy, and by utilizing key insights of scholars of ideational influences on state/market interactions. The article ends with a short agenda for future research on ideas and discourses as a crucial factor in the evolution of the welfare state as a key space in which states and markets interact.
Preparing the soil: Adjusting the metabolic health of patients with chronic wounds and musculoskeletal diseases
Authors: da Fonseca Lucas Furtado , Santos Gabriel Silva , Azzini Gabriel , Mosaner Tomas , Jorge Daniel de Moraes Ferreira , de Macedo Alex Pontes , Huber Stephany Cares , Sobreiro Pablo , Dallo Ignacio , Jeyaraman Madhan , Everts Peter Albert , Navani Annu , Lana José Fábio 
Published: October 2024

AbstractIn recent years, systemic inflammation has emerged as a pivotal player in the development and progression of various degenerative diseases. This complex, chronic inflammatory state, often undetected, can have far‐reaching consequences for the body's physiology. At the molecular level, markers such as C‐reactive protein, cytokines and other inflammatory mediators serve as indicators of systemic inflammation and often act as predictors of numerous musculoskeletal diseases and even certain forms of cancer. The concept of ‘meta‐inflammation’, specifically referring to metabolically triggered inflammation, allows healthcare professionals to understand inflammatory responses in patients with metabolic syndrome. Driven by nutrient excess and the expansion of adipose tissue, meta‐inflammation is closely associated with insulin resistance, further propagating the metabolic dysfunction observed in many Western societies. Wound persistence, on the other hand, exacerbates the detrimental effects of prolonged inflammation at the local level. Acute inflammation is a beneficial and essential process for wound healing and infection control. However, when inflammation fails to resolve, it can impede the healing process, leading to chronic wounds, excessive scarring and even the activation of fibrotic pathways. This approach significantly reduces the efficacy of regenerative biological therapies. Our review focuses on the vital role of proteins, vitamins and minerals in collagen synthesis and cell proliferation for tissue healing. We also examine hormonal influences on regeneration, noting the negative effects of imbalances, and emphasize glucose regulation's importance in creating a stable environment for chronic wound healing.
Quality evaluation of French guidelines in primary care infectious disease: An AGREE II assessment
Authors: Akhamlich Kenza , Gillet‐Lecourt Eulalie , Bouchard Mikaël , Boussageon Rémy 
Published: October 2024

AbstractRationaleAntibiotic prescription, its nature and its duration are a very common decision‐making situation in primary care practice. Clinical practice guidelines (CPGs) are regularly emitted by various organisations on this topic.Aims and objectivesOur goal is to run a quality appraisal of the current French guidelines, for the most common primary care infectious pathologies.MethodWe collected all primary care CPGs that are currently prevailing in France through a systematic review of the french website Antibioclic®. For each of these guidelines, a quality assessment was run by 3 independent reviewers, by means of the Appraisal of Guidelines for REsearch & Evaluation II instrument. The main outcome was a ‘reliability score’, defined as the sum of the scores in domains ‘rigour of development’ and ‘editorial independence’. To be considered ‘reliable’, the CPG had to reach a 60% threshold in these two domains. Secondary outcomes were as follows: global quality score of CPGs, number and ratio of CPGs for which a systematic review has been conducted during its conception.ResultsOver the 43 CPGs that have been assessed, none reached the 60%‐threshold as to the reliability score. Only one CPG (2.33%) gets an over‐60% quality assessment in the domain of rigour of development (D3), whereas three CPGs (6.98%) reach this threshold in the domain of editorial independence (D6). One CPG (2.33%) met the quality threshold of 60% as to overall assessment. Rigour of development and editorial independence are the domains that obtained the lowest average score, respectively, 11% and 21%. Overall assessment received an average score of 29%. A systematic review of the literature was mentioned for 10 CPGs (23.26%).ConclusionThere is a lack of quality in the development process of the current French guidelines in primary care infectiology. This process should be reconsidered, with higher insistence as to its quality.
Effects of supplemental medusa (Rhopilema esculentum) on intestinal microbiota and metabolites in silver pomfret (Pampus argenteus)
Authors: Zhang Man , Tang Mengke , Yan Kaiheng , Zhang Youyi , Li Yaya , Tang Jie , Xu Shanliang , Yan Xiaojun , Hu Jiabao , Wang Yajun 
Published: October 2024

AbstractPampus argenteus demonstrates a preference for Rhopilema esculentum as prey, yet the ramifications of consuming supplemental medusa on fish microbiota and metabolism remain elusive. To elucidate these effects, 300 juvenile fish were divided into two groups: control group (C, given commercial food only) and supplemental medusa (SM) group (given supplemental medusa + commercial feed). After 15 days, fish in the SM group exhibited a significant increase in fatness, the amylase activity in the intestine significantly increased, and the intestinal microvilli were arranged more neatly. The comprehensive approach involving 16S rRNA amplicon sequencing and metabolomics was employed, leading to the identification of five genera within the SM group, namely Lactococcus, Cohaesibacter, Maritalea, Sulfitobacter, and Carnobacterium. Functional prediction analysis of the microbiota indicated that the consumption of supplemental medusa facilitated processes such as glycolysis/gluconeogenesis and amino acid absorption. Metabolomics analysis revealed significant enrichment of 85 differential metabolites, most of them belonging to fatty acids and conjugates. These differential metabolites primarily participated in processes such as amino acid metabolism, fatty acid synthesis, and disease. Notably, the consumption of medusa resulted in a significant reduction in nine lysophospholipids associated with cardiovascular disease and inflammation. Pearson's correlation coefficient analysis revealed associations between specific microorganisms and metabolites, indicating that Cobetia, Weissella, and Macrococcus exhibited an increased abundance in the SM group, positively correlating with apocynin, 12‐Hete, and delta 9‐THC‐d3. The indicator bacteria Psychrobacter reduced in the SM group, exhibiting a negative correlation with cystathionine (a compound involved in glutathione synthesis). Overall, the supplementation of medusa may confer a beneficial effect on the immunity of the fish. This study contributes to the theoretical framework for fish feed development.
Regulation of maize growth and immunity by ZmSKI3‐mediated RNA decay and post‐transcriptional gene silencing
Authors: Gao Jie , Zhang Na , Liu Guohui , Tian Jinjun , Chen Mengyao , Wang Ying , Xing Ye , Zhang Ying , Zhao Chenyang , Mu Xiaohuan , Yu Yanwen , Niu Hongbin , Li Jiankun , Tang Jihua , Gou Mingyue 
Published: October 2024

ABSTRACTDisease resistance is often associated with compromised plant growth and yield due to defense‐growth tradeoffs. However, key components and mechanisms underlying the defense‐growth tradeoffs are rarely explored in maize. In this study, we find that ZmSKI3, a putative subunit of the SUPERKILLER (SKI) complex that mediates the 3′‐5′ degradation of RNA, regulates both plant development and disease resistance in maize. The Zmski3 mutants showed retarded plant growth and constitutively activated defense responses, while the ZmSKI3 overexpression lines are more susceptible to Curvularia lunata and Bipolaris maydis. Consistently, the expression of defense‐related genes was generally up‐regulated, while expressions of growth‐related genes were mostly down‐regulated in leaves of the Zmski3‐1 mutant compared to that of wild type. In addition, 223 differentially expressed genes that are up‐regulated in Zmski3‐1 mutant but down‐regulated in the ZmSKI3 overexpression line are identified as potential target genes of ZmSKI3. Moreover, small interfering RNAs targeting the transcripts of the defense‐ and growth‐related genes are differentially accumulated, likely to combat the increase of defense‐related transcripts but decrease of growth‐related transcripts in Zmski3‐1 mutant. Taken together, our study indicates that plant growth and immunity could be regulated by both ZmSKI3‐mediated RNA decay and post‐transcriptional gene silencing in maize.
“Each person's experience, each person's needs”: How therapists open space for multiple perspectives during reflecting team family therapy supervision
Authors: Sidis Anna Elizabeth , Moore Alison Rotha , Pickard Judy A. , Deane Frank P. 
Published: October 2024

AbstractTom Andersen's reflecting team approach invited family members to hear the dialogues between professionals in response to their stories. This study aimed to explore intersubjective reflexivity during reflecting team group supervision, by observing resonances between group members. Twelve hours of reflecting team group supervision was transcribed and analyzed using Systemic Functional Linguistics. Hallidayan transitivity analysis of selected sections of interaction focused on mental processes, and Martin and White's appraisal framework was used to explore the “engagement” between different voices at play in the conversations. We found the use of physical metaphor to express reflective experiences, multi‐voiced expressions to expand perspectives and possibilities, and dialogical patterns of relating between group therapy participants. Understanding dialogism from a linguistic perspective may offer insights into how reflective dialogues work and support understanding of fidelity for approaches which engage reflecting teams.
LiveLattice: Real‐time visualisation of tilted light‐sheet microscopy data using a memory‐efficient transformation algorithm
Authors: Wang Zichen , Hakozaki Hiroyuki , McMahon Gillian , Medina‐Carbonero Marta , Schöneberg Johannes 
Published: October 2024

AbstractLight‐sheet fluorescence microscopy (LSFM), a prominent fluorescence microscopy technique, offers enhanced temporal resolution for imaging biological samples in four dimensions (4D; x, y, z, time). Some of the most recent implementations, including inverted selective plane illumination microscopy (iSPIM) and lattice light‐sheet microscopy (LLSM), move the sample substrate at an oblique angle relative to the detection objective's optical axis. Data from such tilted‐sample‐scan LSFMs require subsequent deskewing and rotation for proper visualisation and analysis. Such data preprocessing operations currently demand substantial memory allocation and pose significant computational challenges for large 4D dataset. The consequence is prolonged data preprocessing time compared to data acquisition time, which limits the ability for live‐viewing the data as it is being captured by the microscope. To enable the fast preprocessing of large light‐sheet microscopy datasets without significant hardware demand, we have developed WH‐Transform, a memory‐efficient transformation algorithm for deskewing and rotating the raw dataset, significantly reducing memory usage and the run time by more than 10‐fold for large image stacks. Benchmarked against the conventional method and existing software, our approach demonstrates linear runtime compared to the cubic and quadratic runtime of the other approaches. Preprocessing a raw 3D volume of 2 GB (512 × 1536 × 600 pixels) can be accomplished in 3 s using a GPU with 24 GB of memory on a single workstation. Applied to 4D LLSM datasets of human hepatocytes, lung organoid tissue and brain organoid tissue, our method provided rapid and accurate preprocessing within seconds. Importantly, such preprocessing speeds now allow visualisation of the raw microscope data stream in real time, significantly improving the usability of LLSM in biology. In summary, this advancement holds transformative potential for light‐sheet microscopy, enabling real‐time, on‐the‐fly data preprocessing, visualisation, and analysis on standard workstations, thereby revolutionising biological imaging applications for LLSM and similar microscopes.
Injectable Hydrogel With Glycyrrhizic Acid and Asiaticoside‐Loaded Liposomes for Wound Healing
Authors: Zhang Yunqi , Xiong Yu , Wu Xiaochun , Huang Maofang , Li Zhengjie , Zhao Tie , Peng Peng 
Published: October 2024

ABSTRACTBackgroundOpen skin wounds increase the risk of infections and can compromise health. Therefore, applying medications to promote healing at the injury site is crucial. In practice, direct drug delivery is often difficult to maintain for a long time due to rapid absorption or wiping off, which reduces the efficiency of wound healing. Consequently, the development of bioactive materials with both antibacterial and wound‐healing properties is highly desirable.MethodsThis study synthesized liposomes loaded with glycyrrhizic acid (GA) and asiaticoside (AS) by film dispersion‐ultrasonication method, which were then incorporated into a GelMA solution and cross‐linked by ultraviolet light to form a bioactive composite hydrogel for wound dressings.ResultsThis hydrogel is conducive to the transport of nutrients and gas exchange. Compared with GelMA hydrogel (swelling rate 69.8% ± 5.7%), the swelling rate of GelMA/Lip@GA@AS is lower, at 52.1% ± 1.0%. GelMA/Lip@GA@AS also has better compression and rheological properties, and the in vitro biodegradability is not significantly different from that of the collagenase‐treated group. In addition, the hydrogel polymer has a stable drug release rate, good biocompatibility, and an angiogenic promoting effect. In vitro experiments prove that, at concentrations of 0.5, 1, 2, and 3 mg/mL, GelMA/Lip@GA@AS can inhibit the growth of Staphylococcus aureus.ConclusionWe synthesized GelMA/Lip@GA@AS hydrogel and found it possesses advantageous mechanical properties, rheology, and biodegradability. Experimental results in vitro showed that the bioactive hydrogel could efficiently release drugs, exhibit biocompatibility, and enhance angiogenesis and antimicrobial effects. These results suggest the promising application of GelMA/Lip@GA@AS hydrogel in wound‐dressing materials.
A randomized controlled trial on the comparison of two doses of carbetocin with oxytocin for the prevention of postpartum hemorrhage (concert trial)
Authors: Balogun Rasheedat O. , Lawal Olatunji O. , Bello Yusuf O. , Odedele Tolulope M. , Morhason‐Bello Imran O. , Oladokun Adesina 
Published: October 2024

AbstractAimTo compare the effectiveness of 50 and 100 μg of carbetocin with 10 IU of oxytocin for the prevention of postpartum hemorrhage (PPH).MethodsThis was a triple‐blind, non‐inferiority trial involving pregnant women recruited at term. We compared two doses of carbetocin (50 and 100 μg) with 10 IU of oxytocin administered as uterotonic agent after vaginal or cesarean delivery. Uterine contractility was assessed at 2‐ and 5‐min after uterotonic administration. The association between adequate uterine tone and PPH with the patients' characteristics were examined using the chi‐square test. Effect of the drugs on the odds of developing PPH was examined using logistics regressions. All analyses were conducted using STATA (StataCorp L.L.C.) with a significance level set at 0.05.ResultsIn total, 324 women (50 μg carbetocin group‐111, 100 μg carbetocin group‐106, and oxytocin group‐107) participated in the study. There was a significantly higher proportion of women with adequate uterine tone in those that had 100 μg carbetocin relative to 50 μg and 10 IU oxytocin at 5 min (p < 0.001). Patients who received oxytocin had a higher average blood loss than women that had either 50 or 100 μg carbetocin (p = 0.128). There was a significant difference in the need for additional uterotonic, with a higher proportion of participants among those who received 10 IU of oxytocin (p < 0.001).ConclusionPatients that had 100 μg of carbetocin had a better adequate uterine tone at the fifth minute compared to those who had 50 μg and 10 IU of oxytocin. Generally, carbetocin use was less likely associated with risk of PPH and use of additional intervention.
Secondary Traumatic Stress and Coping Experiences in Psychiatric Nurses Caring for Trauma Victims: A Phenomenological Study
Authors: Gülirmak Güler Kübra , Uzun Sevda , Emirza Elif Güzide 
Published: October 2024

ABSTRACTAimIn this study, it was aimed to evaluate the secondary traumatic stress and coping experiences of psychiatric nurses who care for people who have experienced psychological trauma with a phenomenological approach.Materials and MethodsIn this study, semi‐structured in‐depth interviews were conducted with 18 psychiatric nurses residing in Turkey using the phenomenological research method. The criterion sampling method was used to reach the sample group. Interviews continued until data saturation was achieved, and all interviews were audio‐recorded and then transcribed. The data were analysed using thematic analysis. The study was conducted and reported using the COREQ checklist.FindingsIn the analysis of the data, three themes (difficulties in caring for people who have experienced trauma, the effects of caring for people who have experienced trauma on the individual and coping, reflections of secondary trauma on the profession) and seven sub‐themes (mental, physical, social, psychosocial difficulties and coping, quality of care, professional and organisational aspects) were identified.ConclusionAs a result of the study, it was determined that secondary traumatic stress was observed in psychiatric nurses caring for individuals who experienced psychological trauma. It was determined that caring for people who have experienced psychological trauma can negatively affect nurses psychosocially, and individuals have difficulty coping. In line with the results of the study, it is thought that necessary intervention programs should be created for nurses experiencing secondary traumatic stress.
Serum Biochemical Profile, Intestinal and Liver Histomorphometry of Captive Broad‐Snouted Caiman (Caiman latirostris) Fed With a Diet Enriched With Soybean (Glycine max)
Authors: Hilevski Samuel , Cordero Trinidad , Moleón Ma. Soledad , Cabaña Enzo , Belotti Matias , Siroski Pablo 
Published: October 2024

ABSTRACTThe impact of plant‐based diets on crocodilians is unclear. Serum profiles and histomorphometry provide valuable insights into their nutritional and physiological status. This study aims to elucidate the impact of three levels of soybean meal substitution combined chicken by‐product minced on the growth and health of broad‐snouted caiman (Caiman latirostris). The research assesses the effects of diets supplemented with soybean meal on the blood biochemical profile, intestinal histomorphometry, and hepatic parameters of C. latirostris, providing essential information for understanding on the implications of dietary changes in this species. Forty‐eight 6‐month‐old broad‐snouted caimans were assigned to three dietary groups (0%, 25%, 40% soybean meal). Over a period of 90 days, data on growth, food consumption, serum biochemical analysis, intestinal and hepatic morphometry were recorded. The results showed that diets containing higher levels of soybean meal did not significantly affect growth, feed intake or serum profiles of total protein, albumin and cholesterol. However, changes in intestinal morphology were observed, with longer and wider villi in the animals feed with diets with soybean meal, indicating a gradual adaptation to new feeding diets. The presence of soybean meal reduced serum glucose and triglyceride profiles and hepatic lipid accumulation without affecting macronutrient digestion and absorption, considered beneficial for the caiman's health. This study provides valuable insights into the inclusion of soybean meal in the diet of Caiman latirostris and its effects on the intestines, liver, and physiology. It also highlights the importance of considering nutritional management as a key tool in improving the well‐being and health of crocodilians in captivity.
Solving discrete network design problem using disjunctive constraints
Authors: Mirzahossein H. , Najafi P. , Kalantari N. , Waller T. 
Published: October 2024

AbstractThis paper introduces a deterministic algorithm to solve the discrete network design problem (DNDP) efficiently. This non‐convex bilevel optimization problem is well‐known as an non deterministic polynomial (NP)‐hard problem in strategic transportation planning. The proposed algorithm optimizes budget allocation for large‐scale network improvements deterministically and with computational efficiency. It integrates disjunctive programming with an improved partial linearized subgradient method to enhance performance without significantly affecting solution quality. We evaluated our algorithm on the mid‐scale Sioux Falls and large‐scale Chicago networks. We assess the proposed algorithm's accuracy by examining the objective function's value, specifically the total travel time within the network. When tested on the mid‐scale Sioux Falls network, the algorithm achieved an average 46% improvement in computational efficiency, compared to the best‐performing method discussed in this paper, albeit with a 4.17% higher total travel time than the most accurate one, as the value of the objective function. In the application to the large‐scale Chicago network, the efficiency improved by an average of 99.48% while the total travel time experienced a 4.34% increase. These findings indicate that the deterministic algorithm proposed in this research improves the computational speed while presenting a limited trade‐off with solution precision. This deterministic approach offers a structured, predictable, and repeatable method for solving DNDP, which can advance transportation planning, particularly for large‐scale network applications where computational efficiency is paramount.