bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retos de la ética en la investigación socio jurídica: revisión a partir de buenas prácticas en artículos publicados
Authors: Bernal-Camargo Diana Rocío , Díaz Amado Eduardo , Padilla Muñoz Andrea Carolina 
Published: December 2017

El presente artículo pretende proporcionar una mirada a las consideraciones y reflexiones desde la ética de la investigación enfocada a la investigación socio jurídica. La literatura en éste campo se ha ocupado de reflexionar sobre la ética de la investigación en las ciencias sociales, dentro de la que se encuentra la investigación socio jurídica. Este tipo de investigación en el campo del derecho presenta sus consideraciones teóricas propias, que aquí nos permiten encontrar una aproximación a la problemática de la definición misma de este tipo de investigación. Para efectos de presentar el análisis desde la ética de la investigación, se revisaron 10 artículos de resultado de investigación socio jurídica desde la perspectiva ética, tomando como punto de partida las consideraciones de la ética de la investigación con sujetos humanos del área de la biomedicina. En los artículos referidos se encontró que en efecto este tipo de investigaciones toman en consideración diferentes pautas éticas – no establecidas formalmente - que buscan el respeto a los derechos de los participantes, con las particularidades propias de la investigación socio jurídica que merecen ser tomadas en cuenta. El artículo concluye con algunas sugerencias desde lo práctico y lo metodológico en relación con la ética de la investigación socio- jurídica.
Custos de produção na empresa e no mercado: uma visão
Authors: Silva Sergio Evangelista , Curi Filho Wagner Ragi 
Published: December 2017

Um dos dilemas fundamentais da firma reside em executar determinada atividade no mercado, ou no seu interior. Na literatura é a economia dos custos de transação (ECT) que melhor permite esta análise, apresentando a forma de governança adequada para determinada atividade. Contudo, a ECT sozinha não permite analisar completamente esta questão, por não abordar em profundidade o papel da configuração dos recursos produtivos na eficiência de determinada atividade. Duas questões a este respeito ainda são prementes: Quais os fundamentos da eficiência do mercado e das firmas que definem o custo da atividade nestes dois meios? Qual é a estrutura comparativa dos custos relativa à execução de determinada atividade nestes dois meios? Diante destas duas questões este artigo tem por objetivo propor um modelo dos custos de produção na empresa e no mercado, baseado na eficiência dos fatores de produção e nos custos de transação. Esta proposta é feita à luz dos pressupostos da ECT, da organização industrial (OI) e da visão baseada nos recursos (VBR). Como principal resultado este modelo permite compreender como os custos de transação e a eficiência dos fatores de produção determinam o desenvolvimento das empresas e do sistema econômico como um todo.
Zwischen ethischer Neutralität und Dehumanisierung
Authors: Rüther Markus 
Published: December 2017

AbstractIt is an undoubted fact that neuroscientific models of explanation play a crucial role in the realms of science and public life. Besides some noteworthy theoretical problems (unserious experimental set-ups, mis- or overinterpretation, illegitimate analogies, etc.) there are also practical problems concerning the neuroscientific explanation monopoly. To bring those problems to light, it is reasonable to concentrate on a specific and currently prominent version of modelling – namely that undertaken by so-called biological psychiatry. In this article, it will be shown that the controversy concerning biological psychiatry is often guided by several misunderstandings and wrong-headed accusations. The article starts by giving a minimal definition of biological psychiatry which can be used as a common ground for further argumentation. It differentiates three subprojects of biological psychiatry and examines their risks and potentials in more detail. In sum, the article argues for a nuanced attitude towards biological psychiatry: If we are concerned with diagnostic practices and biological underpinnings of mental illnesses we are well-informed by the methods of biological psychiatry. However, if we want to know something about the nature of mental illnesses, we should imagine other projects which are theoretically much better equipped to answer ontological questions.
Identity navigation, story evaluation and recipient identification inThe Graham Norton Show’s “Red Chair stories”
Authors: Verhelst Avril , Van De Mieroop Dorien 
Published: December 2017

AbstractFor the evaluation of a story, story recipients rely on a narrator’s identity work. Uniquely, these related processes of identity work and story evaluation unfold explicitly in the Red Chair segment ofThe Graham Norton Show, where “bad” stories are rejected by flipping the narrator out of a red chair, and narrators of “good” stories may walk away from the chair. We collected every Red Chair story broadcast in 2013 and analyzed these by drawing on Bamberg (2011, Narrative practice and identity navigation. In James A. Holstein & Jaber F. Gubrium [eds.],Varieties of narrative analysis, 99–124. London: Sage)’s three main dimensions of identity navigation, namely, agency, sameness/difference, and constancy/change. The analyses reveal diverging tendencies, which we bring together by means of the concept of identification, viz. (i) the story recipient’s affiliation with the protagonist of the story and/or with the narrator, or (ii) the recipient’s vicarious experience of the events. We propose that a story recipient’s evaluation can be related to the extent to which identification is elicited. This identification is not only based on the navigational dimension of sameness/difference, as often proposed, but it is, among others, a result of the narrator’s unique identity navigation along the three closely interwoven dimensions, thus also including agency and constancy/change.
Seizure Forecasting from Idea to Reality. Outcomes of the My Seizure Gauge Epilepsy Innovation Institute Workshop
Authors: Dumanis Sonya B. , French Jaqueline A. , Bernard Christophe , Worrell Gregory A. , Fureman Brandy E. 
Published: December 2017

AbstractThe Epilepsy Innovation Institute (Ei2) is a new research program of the Epilepsy Foundation designed to be an innovation incubator for epilepsy. Ei2research areas are selected based on community surveys that ask people impacted by epilepsy what they would like researchers to focus on. In their 2016 survey, unpredictability was selected as a top issue regardless of seizure frequency or severity. In response to this need, Ei2launched the My Seizure Gauge challenge, with the end goal of creating a personalized seizure advisory system device. Prior to moving forward, Ei2convened a diverse group of stakeholders from people impacted by epilepsy and clinicians, to device developers and data scientists, to basic science researchers and regulators, for a state of the science assessment on seizure forecasting. From the discussions, it was clear that we are at an exciting crossroads. With the advances in bioengineering, we can utilize digital markers, wearables, and biosensors as parameters for a seizure-forecasting algorithm. There are also over a thousand individuals who have been implanted with ambulatory intracranial EEG recording devices. Pairing up peripheral measurements to brain states could identify new relationships and insights. Another key component is the heterogeneity of the relationships indicating that pooling findings across groups is suboptimal, and that data collection will need to be done on longer time scales to allow for individualization of potential seizure-forecasting algorithms.
Hypercalcemia of malignancy treated with cinacalcet
Authors: Asonitis Nikolaos , Kassi Eva , Kokkinos Michalis , Giovanopoulos Ilias , Petychaki Foteini , Gogas Helen 
Published: December 2017

Summary
Hypercalcemia of malignancy is the most common cause of hypercalcemia in hospitalized patients. It is associated with a poor prognosis, since it reflects an advanced cancer stage. Among all cancer in females, breast cancer is the most common malignancy, and it has the highest prevalence of hypercalcemia. Approximately 70% of patients with breast cancer have bone metastases and 10% of them will have hypercalcemia as a complication at some point in the disease. Herein, we report a 69-year-old female patient with metastatic breast cancer, who developed severe hypercalcemia in the course of her disease and was diagnosed with humoral hypercalcemia of malignancy (HHM). Intense hydration along with corticoisteroids and antiresorptive medication (calcitonin, bisphosphonates and denosumab) were administered to the patient. Despite the above treatment, serum calcium levels remain elevated and calcimimetic cinacalcet was added. Upon discontinuation of cinacalcet, calcium levels were raised and returned back to the normal levels following re-initiation of the calcimimetic. Her calcium level restored to normal, and she was discharged with the following medical treatment: denosumab monthly, and cinacalcet at a titrated dose of 90 mg per day. The patient is followed as an outpatient and 11 months later, her calcium level remained within the normal range.

Learning points:

Hypercalcemia of malignancy is the most common cause of hypercalcemia in hospitalized patients.

Breast cancer has the highest prevalence of hypercalcemia.

The cornerstone of therapy remains the intense hydration and intravenous bisphosphonates (preferably zoledronic acid).

In case of persistent hypercalcemia of malignancy, the administration of calcimimetic cinacalcet could be an additional effective therapeutic option.
Dosage-Dependent Expression Variation Suppressed on the Drosophila Male X Chromosome
Authors: Lee Hangnoh , Cho Dong-Yeon , Wojtowicz Damian , Harbison Susan T , Russell Steven , Oliver Brian , Przytycka Teresa M 
Published: December 2017

Abstract
DNA copy number variation is associated with many high phenotypic heterogeneity disorders. We systematically examined the impact of Drosophila melanogaster deletions on gene expression profiles to ask whether increased expression variability owing to reduced gene dose might underlie this phenotypic heterogeneity. Indeed, we found that one-dose genes have higher gene expression variability relative to two-dose genes. We then asked whether this increase in variability could be explained by intrinsic noise within cells due to stochastic biochemical events, or whether expression variability is due to extrinsic noise arising from more complex interactions. Our modeling showed that intrinsic gene expression noise averages at the organism level and thus cannot explain increased variation in one-dose gene expression. Interestingly, expression variability was related to the magnitude of expression compensation, suggesting that regulation, induced by gene dose reduction, is noisy. In a remarkable exception to this rule, the single X chromosome of males showed reduced expression variability, even compared with two-dose genes. Analysis of sex-transformed flies indicates that X expression variability is independent of the male differentiation program. Instead, we uncovered a correlation between occupancy of the chromatin-modifying protein encoded by males absent on the first (mof) and expression variability, linking noise suppression to the specialized X chromosome dosage compensation system. MOF occupancy on autosomes in both sexes also lowered transcriptional noise. Our results demonstrate that gene dose reduction can lead to heterogeneous responses, which are often noisy. This has implications for understanding gene network regulatory interactions and phenotypic heterogeneity. Additionally, chromatin modification appears to play a role in dampening transcriptional noise.
The recombinant fusion protein CFP10–ESAT6–dIFN has protective effect against tuberculosis in guinea pigs
Authors: Permyakova Natalya V. , Belavin Pavel A. , Pirozhkova Dariya S. , Ufimtseva Elena G. , Rozov Sergey M. , Mursalimov Sergey R. , Sidorchuk Yuriy V. , Uvarova Elena A. , Zagorskaya Alla A. , Marenkova Tatiana V. , Bannikova Svetlana V. , Demidov Evgeniy A. , Starostin Konstantin V. , Kravchenko Marionella A. , Vakhrusheva Diana V. , Berdnikov Roman B. , Eremeeva Natalya I. , Skornyakov Sergey N. , Peltek Sergey E. , Deineko Elena V. 
Published: December 2017

Development of effective vaccine candidates against tuberculosis (TB) is currently the most important challenge in the prevention of this disease since the BCG vaccine fails to guarantee a lifelong protection, while any other approved vaccine with better efficiency is still absent. The protective effect of the recombinant fusion protein CFP10–ESAT6–dIFN produced in a prokaryotic expression system (Escherichia coli) has been assessed in a guinea pig model of acute TB. The tested antigen comprises the Mycobacterium tuberculosis (Mtb) proteins ESAT6 and CFP10 as well as modified human γ-interferon (dIFN) for boosting the immune response. Double intradermal immunization of guinea pigs with the tested fusion protein (2 × 0.5 µg) induces a protective effect against subsequent Mtb infection. The immunized guinea pigs do not develop the symptoms of acute TB and their body weight gain was five times more as compared with the non-immunized infected guinea pigs. The animal group immunized with this dose of antigen displays the minimum morphological changes in the internal organs and insignificant inflammatory lesions in the liver tissue, which complies with a decrease in the bacterial load in the spleen and average Mtb counts in macrophages.
Imagen mental y perfil de competencias del puesto de policía local
Authors: Lado Campelo Mario Antonio 
Published: December 2017

El objetivo del estudio era determinar el perfil del puesto de Policía Local a través de la declaración de descriptivos de competencias laborales y de las imágenes mentales de los policías locales. 24 policías locales aportaron descriptores referidos a la imagen del mejor Policía Local, y evaluaron la relevancia de las pruebas de selección. Los resultados indicaron que los descriptivos más frecuentes se referían a las competencias de Colaboración, Flexibilidad, Excelencia, Conocimientos técnicos y Trabajo en Equipo, y que las pruebas de evaluación más relevantes eran los conocimientos, los psicotécnicos y las aptitudes físicas.
Importancia de las imágenes espaciales en el rendimiento académico en Economía
Authors: Dopico Jesús A. , González María Ángeles , Campos-Juanatey Diego 
Published: December 2017

Para analizar la influencia de la habilidad espacial, de rotar imágenes y del género, en el rendimiento en Economía, a 119 estudiantes de Administración y Dirección de Empresas, se les aplicó el test MASMI, y el test MRT. Se examinaron de un modelo gráfico utilizado en macroeconomía, y se obtuvo la calificación en Política Económica. Mujeres y participantes con alta habilidad para rotar imágenes, obtuvieron puntuaciones superiores en ambas medidas, a hombres y participantes con baja habilidad, respectivamente. La puntuación en gráficos de altos en habilidad de imagen espacial fue superior a la de los bajos en habilidad espacial.
Orientações motivacionais de adolescentes praticantes de modalidades náuticas
Authors: Cruz Mário , Santos Luísa Ramos , Rodrigues Luís Paulo 
Published: December 2017

A prática de modalidades náuticas tem vindo assumir um importante papel no processo educativo global. Neste estudo pretendemos caracterizar o nível motivacional de adolescentes praticantes náuticos em diferentes orientações motivacionais, as suas perceções e dos seus pais relativamente à prática da náutica de competição e o rendimento académico. Aplicamos uma Escala de Orientações Motivacionais (Skaalvik, 1997; Peixoto, Mata e Monteiro, 2008), e um questionário sociodemográfico a uma amostra de 103 adolescentes dos 11 aos 17 anos. Os resultados obtidos apontam uma relação positiva entre a prática de modalidades náuticas, a percepção de bem‑estar e a prossecução de objetivos académicos.
Relación entre la ansiedad matemática y rendimiento en estudiantes de Química
Authors: Méndez Fernández Shirley , Rodríguez Ayán María Noel 
Published: December 2017

Se procura explorar las relaciones entre la ansiedad matemática (AM) de estudiantes de primer año de Química y sexo, carrera y rendimiento. Se utilizó el cuestionario Short Mathematics Anxiety Rating Scale (SMARS), cuyas medidas arrojaron una estructura tridimensionalidad de la ansiedad. Se realizaron ANOVA, t-Student y correlaciones de Pearson (α=.05). Los hombres presentan mayor AM. La carrera, el número de veces que reprobó el examen de matemática y el total de exámenes perdidos están relacionados con distintos componentes de la ansiedad. Es necesario profundizar para una mayor comprensión de estas relaciones.
Escala de avaliação das estratégias de regulação da motivação de alunos universitários: um estudo piloto
Authors: Góes Natália Moraes , Boruchovitch Evely 
Published: December 2017

Os objetivos do estudo foram: realizar um estudo piloto para verificar a adequação da tradução de uma escala que mensura o uso de estratégias de regulação da motivação de estudantes universitários, originalmente da língua inglesa (Wolters & Benzon, 2013), para a língua portuguesa e analisar o autorrelato do uso dessas estratégias em função do sexo e área de conhecimento do curso dos estudantes. Participaram 42 estudantes de cursos de licenciaturas diversas que responderam a versão traduzida da escala e uma questão sobre a compreensão dos itens. Resultados revelaram que a escala se mostrou adequada para uso no Brasil.
A toma de consciencia do ritmo en Educación Infantil.Un estudo comparativo entre Dalcroze e Kodály
Authors: Castiñeiras Pereira Laura , Díaz Pereira María del Pino 
Published: December 2017

A toma de consciencia do ritmo, constitúe unha competencia relevante para o desenvolvemento integral do alumnado na etapa de Educación Infantil. Por isto, o presente traballo analiza qué metodoloxía musical resulta máis eficaz para traballar dita competencia con infantes de 3 anos. Para isto, fixemos un estudo descritivo comparativo entre a metodoloxía Dalcroze, baseada no movemento, e a Kodály, sustentada no canto. 36 suxeitos de 3 anos do CEIP de Silleda participaron nesta investigación. 18 deles foron educados musicalmente con Kodály e os outros 18 con Dalcroze. Os resultados indican que o grupo Dalcroze mostrou resultados significativamente superiores.
A Escolha dos Líderes e a Compreensão Emocional na Educação Pré-Escola
Authors: Franco Maria Glória , Jardim Sara 
Published: December 2017

Este estudo teve por objectivo perceber a importância que as variáveis pessoais, as relações interpessoais e a compreensão emocional poderão ter na escolha de um líder em crianças a frequentar o Ensino Pré-Escolar. Participaram quarenta e cinco crianças, 46,7% do sexo feminino e 53,3% do sexo masculino, com idades entre os três e seis anos, da Região Autónoma da Madeira (RAM). Os resultados mostraram que o sexo e ter irmãos, bem como, a preferência social, o impacto social, o estatuto social influenciam a escolha para líder. Da compreensão emocional só a regulação emocional mostrou estar associada a esta escolha.
Educación Ambiental e Educación para a Cidadanía Global: encontro de movementos educativos?
Authors: Serantes-Pazos Araceli 
Published: December 2017

A Educación Ambiental é un movemento educativo que xurde nos 60, como resposta ao deterioro ambiental, da man de científicas/os, naturalistas e ecoloxistas; a Educación para o Desenvolvemento xurde tras a II Guerra Mundial como resposta educativa solidaria fronte ao somentemento dos pobos, da man dos pacifistas, relixiosos ou partidos políticos. Ambos son movementos educativos internacionais, apoiados por Organismos internacionais, Gobernos nacionais e Grupos locais. Aínda que tiveron comenzos, obxectivos e actores dispares, están nun punto de encontro na Educación para a Cidadanía Global. Mostramos as sinerxias e singularidades destes movementos como espazos de transformación e innovación educativa.
Programa mais educação: responsabilização e comprometimento coletivo para um desenvolvimento humano e sustentável
Authors: Pinheiro Maria Deuceny , Pinheiro Alfredo Bravo Marques , Ferreira António Gomes 
Published: December 2017

Esta comunicação apresenta um recorte da análise feita sobre o desenvolvimento do Programa Mais Educação em Cachoeiro de Itapemirim, ES, Brasil. O Programa, pautado nos baixos índices de aprendizagem das escolas públicas brasileiras, apresenta uma concepção holística de educação voltada para uma formação plena do cidadão e para o desenvolvimento sustentável. Conduzimos nosso estudo enfatizando a importância da participação como dispositivo de responsabilização e comprometimento coletivo. Os dados apresentados enfatizam o quão significativos podem ser os arranjos educativos envolvendo escola, família e comunidade para o desenvolvimento de uma cultura de cidadania e de transformação social.
A participação dos alunos nos projetos de melhoria das escolas
Authors: Moraes Bianca Mota de , Mouraz Ana , Cosme Ariana 
Published: December 2017

Procuramos aqui abordar a importância da participação dos alunos para a melhoria das escolas. O aumento da escolaridade obrigatória e a universalização do seu acesso, em Portugal, abrem novos desafíos à discussão sobre a voz dos alunos acerca da sua experiencia e participação na vida escolar Quais os meios que promovem a participação dos estudantes na vida da escola? Nesta linha de raciocínio pesquisamos o Orçamento Participativo das Escolas, instituído no iní
Intellectual Capital as a Competitive Advantage in Pan African Nigeria Limited, Abuja
Authors: Opusunju Michael Isaac , Jiya Ndalo Santeli , Akyuz Murat 
Published: December 2017

<p class="Default">The study examines the relationship between intellectual capital and competitive advantage in Pan African Nigeria Limited, Abuja. The study also sought to find out how intellectual capital (human capital, social capital, relational capital and structural capital) enhances competitive advantage in Pan African Nigeria Limited, Abuja. The population of 65 employees were used and the population was used as sample size. Point in time data were collected from primary source and Ordinary Least Square was adopted and finding reveals that the relationship between intellectual capital and competitive advantage in Pan African Nigeria Limited is significant. This shows that there is a significant relationship between human capital and competitive advantage in Pan African Nigeria Limited, Abuja. There is a significant relationship between relational capital and competitive advantage in Pan African Nigeria Limited, Abuja. There is a significant relationship between structural capital and competitive advantage in Pan African Nigeria Limited, Abuja. There is a significant relationship between social capital and competitive advantage in Pan African Nigeria Limited, Abuja. It is therefore recommended that Pan African Nigeria Limited should emphasis more on intellectual capital such as human capital, social capital, relational capital and structural capital since it help them to achieve competitive advantage over other firms within the industry.</p>