bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracés territoriaux d’un point de vue sémiotique
Authors: Boudon Pierre 
Published: November 2017

Abstract
By “territorial lines,” we do not mean the physical appearance of a natural landscape in its multiple manifestations but an underlying level of schematization that constitutes it as text and/or iconic picture, an intermediary between these manifestations and the set of conceptual notions that underlies it (mountain, valley, plain, river, coast, etc.). In this way, territorial lines are similar to Peircian diagrams, halfway between images and symbols. It is a level of immanence that traverses different types of demonstration, natural reliefs, cartography, pictorial expressions (as in the work of Klee, for example), and choreography (as with Laban). This paper compliments the one we proposed online in 2014 in the Actes Sémiotiques (vol. 117), about a genesis of territory.
Narration and the experience of history
Authors: Flores Roberto 
Published: November 2017

Abstract
For a long time, history has been conceived as a textual fact, whether as positive knowledge of the past, reported in chronicles and original sources, or through acknowledgment of its textual basis, assumed as historiography, as narrative history. In either case, the text appears as the source and goal of knowledge, and has assumed the nature of an immutable monument, an invariable object of reference and information. These texts are limited to constituting a regulatory storehouse of knowledge, a mere object of appropriation. In contrast, we can consider history not just as knowledge enclosed in textual containers, but as experience inscribed in peoples´ memory. This is what Mexican historian Edmundo O’Gorman suggests with his proposal to consider history as readers formulating their own versions of the past. Through these proposals, semiotics is in a position to describe the role of texts in the production of a vicarious experience of history through the act of reading. This paper provides examples taken from accounts of the Spanish Conquest of Mexico and proposes a semiotic interpretation of the experience of history.
Non-invasive assessment of the bioburden of minced pork using a hand-held fluorescence device
Authors: Grimmler Christina , Kuhfuß Tamara , Heiden Matthias , Schmidt Heinar 
Published: November 2017

Abstract
To speed-up monitoring of the hygienic status of meat, fast and
non-invasive measuring techniques are required. In this work, the
feasibility was investigated to quantify the bioburden of minced meat
with a hand-held fluorescence spectrometer. In two
independent trials, 144 (165) minced pork samples from 18 (23) batches
were stored at 2 ℃ for up to 8 (7) days. Fluorescence spectra, L*a*b*
colour and total viable mesophilic plate counts (TVC) were measured in
parallel. TVC varied from 2.7 to 10.4 log(TVC/g) in
this period. Correlation of the fluorescence spectra with log(TVC/g)
using partial least squares regression yielded cross-validated
predictions with R2cv = 0.72 (0.83) and a prediction error
of RMSECV = 0.97 (0.69) log(TVC/g). Cross-validated limits of
detection and quantification were determined as 1.0 (0.9) and
3.4 (3.2) log(TVC/g), respectively. This would allow for
a quantification well below the alarm threshold of 5.7–6.7 log(TVC/g). The spectra were strongly correlated with storage time
with R2cv = 0.81 (0.67), but less strong with L*a*b*
colour. Storage time was identified as interference which was reduced
in the second trial by modifying the sampling.
A Src/Abl kinase inhibitor, bosutinib, downregulates and inhibits PARP enzyme and sensitizes cells to the DNA damaging agents
Authors: Kirmizibayrak Petek Ballar , Ilhan Recep , Yilmaz Sinem , Gunal Selin , Tepedelen Burcu Erbaykent 
Published: November 2017

Abstract

Background
Poly(ADP-ribosyl)ation (PARylation) catalyzed mainly by PARP1 is a highly regulated posttranslational modification associated with several pathways in cellular physiology and genotoxic deoxyribonucleic acid (DNA) damage response. PAR polymers and PARP enzyme function in DNA integrity maintenance and several PARP inhibitors have entered clinical phase studies for cancer therapies.

Material and methods
The effect of bosutinib, a dual Src/Abl kinase inhibitor, on PARylation was fluorometrically measured. The cytotoxic and chemosensitizing effects were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The levels of DNA repair proteins and PARP enzyme were examined by immunoblotting.

Results
In this study, bosutinib is characterized as a novel PARP inhibitor. Bosutinib inhibited oxidative stress-induced cellular PARylation and nuclear foci formation by downregulating PARP1 levels. Bosutinib was found to be more cytotoxic on Capan1 cells with BRCA2 mutation. Furthermore by acting as a chemosensitizer, bosutinib enhanced the cytotoxicity of doxorubicin (DOXO) and etoposide (ETP) by decreasing phosphorylation of DNA repair enzymes checkpoint kinase 1 (Chk1) and ataxia-telangiectasia mutated (ATM).

Conclusion
By inhibition of both PARP and DNA damage checkpoint kinases, bosutinib increased the phospho-H2AX levels, an early indicator of DNA double strand breaks.
Resistivity, Penetrability and Porosity of Concrete: A Tripartite Relationship
Authors: Bediwy A. , Bassuoni M. T. 
Published: November 2017

AbstractDemands for using electrical resistivity techniques (surface and bulk resistivity) as an alternative to the rapid chloride penetrability test (RCPT) have been growing, for example by a number of transportation agencies in North America, to give an indication of the relative penetrability of concrete. While resistivity measurements may reflect the quality of pore structure in the cementitious matrix, their accuracy might be affected by a multitude of parameters including the concentration of ionic species in the pore solution, particularly when supplementary cementitious materials (SCMs) are incorporated in the binder. Hence, a systematic investigation on the resistivity of concrete and its corresponding physical penetrability is warranted. The main objective of this study was to establish a tripartite relationship (nomogram) to correlate surface resistivity with penetrability (migration coefficient) and porosity of concrete using a wide range of concrete mixtures, taking into account the effect of key mixture design parameters (water-to-binder ratio, air-entrainment, SCMs, and type of cement). Relationships between surface and bulk resistivity as well as migration coefficient and porosity of concrete were also established. In addition, a penetrability classification of concrete based on the corresponding ranges of surface resistivity, migration coefficient, and porosity has been proposed. The efficacy/practicality of the proposed classification was evaluated by comparing the predicted migration coefficient and porosity, based on surface resistivity of concrete, to the measured ones for field cores extracted from concrete pavement in Winnipeg, Canada. For newly constructed and aging pavement, the nomogram and penetrability classification provided reasonable assessment for the condition of field concrete.
Strength of Aluminum Alloys Under Static Mixed-Mode I/II Loading Conditions
Authors: Tariq F. , Khan M. , Farhan M. , Siddiqui M. Z. 
Published: November 2017

Abstract
Structures for aerospace and space applications often experience combination of tension and shear-loading conditions beside pure tensile opening loads (mode I). This paper presents the results of mixed-mode load tests conducted on two different grades of aluminum alloys frequently used in aerospace, automotive, and industrial structures. Testing was conducted using butterfly specimens and Arcan fixtures. Specimens were tested at different loading angles ranging from pure tension (mode I) to pure shear (mode II), as well as mixture of both modes I/II. Strength-loading-angle correlation was established. The results showed that the strength decreases linearly with increasing loading angle from pure tension to pure shear. About 45 %–47 % reduction in strength was observed upon changing loading scenario from pure tensile to pure shear. Displacements at different loading angles were measured using the digital image correlation (DIC) method and have been found to increase load mixity. Ratio of shear to tensile strength was calculated to be in range of 0.53–0.54 for aluminum alloys tested in this work. Crack extension and fracture mechanism deviated with the stress state. Finite-element modeling was also carried out and it was found to be in good agreement with the experimental results.
Electromagnetic Crimping in Tube-to-Cylinder Configuration: Influence of the Base Profiles on the Joint Quality
Authors: Kumar R. , Kore S. D. 
Published: November 2017

Abstract
Electromagnetic crimping is a high-speed impact joining technique. In this paper, Al 1050 tubes were successfully joined on the steel 1020 rod. Three types of profiles were created on the steel rod for crimping the aluminum tube. The profiles on the steel rod created were plain, knurled, and threaded. The variation in the joint strength and the microstructure of the joint with the change in profile was analyzed and compared. For joint strength comparison, pull-out tests were carried out. The result of the pull-out test revealed that the threaded profile on the steel rod gives the highest strength in comparison to the other profiles. The microstructure of the obtained joint showed that there was no gap between the Al tube and the steel rod at 5.3 kJ of discharge energy. There was an increase in the micro-hardness of the analyzed layers compared to the base materials. The reason for the increase was probably due to deformation of the tube layer during electromagnetic crimping and their strain hardening. Surface roughness (Ra) values of the crimped samples at 5.3 kJ were analyzed, and it was found that the Ra value of the sample crimped on the threaded base was highest among threaded, knurling, and plain base samples.
Design and Dynamic Force Verification of Instrumented Charpy Strikers for the Tinius Olsen Pendulum Impact Tester
Authors: Schuurmans J. 
Published: November 2017

Abstract
The reliable measurement of characteristic force values from instrumented Charpy impact tests is considered of high importance at SCK•CEN in view of the “Enhanced Surveillance” of nuclear reactor pressure vessels. The previous development of instrumented strikers for the Toni MFL pendulum impact tester at SCK•CEN demonstrated that the static and dynamic performance of instrumented strikers is influenced by their design, especially the location of the strain gauges. To further improve our design know-how, instrumented ASTM (8 mm radius) and ISO (2 mm radius) strikers are developed for a Tinius Olsen pendulum impact tester. The dynamic performance of these strikers is greatly improved by incorporating new insights in the design. The strikers are extensively tested and meet the requirements of the current ISO 14556 and ASTM E2298-15 standard on the permissible error for the static force calibration of the striker and the limitations on the difference between the absorbed energy and the energy computed from the force-time curve. The ASTM strikers even meet the more stringent requirement on the permissible energy difference of the ISO 14556 standard of ±5 J. The verification of the dynamically measured maximum force value using NIST reference material failed for SRM 2112 but succeeded for SRM 2113 specimens. Because the dynamic force verification using standard reference material is not always reliable, an alternative verification method was evaluated. The comparison of the general yield stress inferred from instrumented Charpy impact tests, using Server’s equation, with the yield stress obtained from dynamic tensile testing of the same material at an equivalent strain rate, demonstrated to be a good method for the verification of the dynamically measured force. This method proved to be independent of the striker radius for our design.
Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea
Authors: Browne Lorcan , Smith Katie E. , Jagger Daniel J. 
Published: November 2017

AbstractIn spiral ganglion neurons (SGNs), the afferent single units of the auditory nerve, high spontaneous and evoked firing rates ensure preservation of the temporal code describing the key features of incoming sound. During postnatal development, the spatiotemporal distribution of ion channel subtypes contributes to the maturation of action potential generation in SGNs, and to their ability to generate spike patterns that follow rapidly changing inputs. Here we describe tetrodotoxin (TTX)-sensitive Na+currents in SGNs cultured from mice, whose properties may support this fast spiking behavior. A subthreshold persistent Na+current (INaP) and a resurgent Na+current (INaR) both emerged prior to the onset of hearing and became more prevalent as hearing matured. Navβ4 subunits, which are proposed to play a key role in mediating INaRelsewhere in the nervous system, were immunolocalized to the first heminode where spikes are generated in the auditory nerve, and to perisomatic nodes of Ranvier. ATX-II, a sea anemone toxin that slows classical Na+channel inactivation selectively, enhanced INaPfive-fold and INaRthree-fold in voltage clamp recordings. In rapidly-adapting SGNs under current clamp, ATX-II increased the likelihood of firing additional action potentials. The data identify INaPand INaRas novel regulators of excitability in SGNs, and consistent with their roles in other neuronal types, we suggest that these nonclassical Na+currents may contribute to the control of refractoriness in the auditory nerve.
¿Qué creen y aconsejan psicólogos (as) chilenos (as) y costarricenses sobre la crianza de los (as) hijos (as) ?
Authors: Castro Carrasco Pablo Javier , Alaniz Flores Paz Belén , Carmona Cortés Daniela Marisol , Pizarro Rojas Tatiana Paulina , Soto Fernández Camila Monserrat , Fuster Barahona Delia Tamara 
Published: November 2017

Este estudio investigó las teorías subjetivas de 12 psicólogos(as) chilenos(as) y costarricenses que trabajan en temáticas de infancia, a objeto de poder describir e interpretar sus explicaciones sobre la crianza. Esta investigación fue de carácter cualitativo, con un diseño metodológico descriptivo-interpretativo. Se realizaron entrevistas episódicas, analizadas utilizando el modelo de la Grounded Theory (teoría fundamentada). Los participantes señalaron usar sus propias experiencias y creencias al aconsejar a los padres y a las madres. Según los (as) entrevistados (as), los padres y las madres consultan principalmente sobre la impulsividad y disciplina de los (as) hijos (as). De acuerdo a los (as) entrevistados (as), los estilos parentales más recurrentes son el autoritario y el permisivo, este último asociado con el miedo y ansiedad de los padres y madres.
Aerobics as a Factor to Motivate Self-Development of the Females
Authors: Poteliūnienė Sniegina , Baltuškonienė Ineta 
Published: November 2017

Organized workouts of aerobics might be seen as a self-development tool, as adult person’s decision to get involved into certain activity is taken consciously. One perceives such engagement being related to satisfaction of certain needs and expectations to reach the results of the systematically performed activity. The research was launched in order to reveal the motives of the females’ decision making when choosing aerobics for self-development, as well as to disclose the perceived by women impact of aerobics, considering it as a self-development tool.
Half-structured interview method was applied for the research. 11 females, who attended Vilnius aerobics study, were interviewed. The data of the research were processed using qualitative content analysis, based on expert evaluation. It was established that women considered such values as family, health, carrier and happiness being the most important for them. Several universally accepted values were pointed out to be positive personal values, either already possessed or to be perfected further on by the respondents. These values were named to have been a motivating factor in choosing aerobics for self-development. Both intrinsic and extrinsic motives reinforce women to choose aerobics. Impact of aerobics as self-development tool was expressed by such aspects: rise of new needs, better psychic health, development of social relations and better quality, better results at work, gradually increasing body attractiveness. These facts prove that aerobics has a power to enable women to implement their inner potential, to satisfy their needs, to improve the quality of life, considering the fact that satisfaction with the results of sports activity is of the preconditions to form intrinsic motivation from extrinsic.
A Systematic Review of Health-Related Quality of Life Reporting in Ovarian Cancer Phase III Clinical Trials: Room to Improve
Authors: Wilson Michelle K. , Friedlander Michael L. , Joly Florence , Oza Amit M. 
Published: November 2017

Abstract

Background
Epithelial ovarian cancer (OC) remains a significant cause of morbidity and mortality for women worldwide. Patients may experience a multitude of disease- and treatment-related symptoms that can impact quality of life (QOL) and should be measured and reported in clinical trials. This systematic review investigated the adequacy of reporting of QOL in randomized phase III trials in OC in both the first-line and recurrent disease setting.

Materials and Methods
A systematic review of MEDLINE and EMBASE identified randomized clinical trials of systemic therapy in OC from 1980 to 2014. The adequacy of reporting QOL was evaluated with respect to adherence to established guidelines on reporting QOL in clinical trials and the recent recommendations on the inclusion of patient-reported outcomes in clinical trials from the Fifth Ovarian Cancer Consensus Conference.

Results
Of 3,247 abstracts, 35 studies, including 24,664 patients, met inclusion criteria. Twenty-two trials (63%) were in the first-line setting, with 13 (37%) in the recurrent setting. The inclusion of QOL assessments increased from 2% (1980s) to 62% (2010+). Quality of life was a co–primary endpoint in only one trial.
Minimal clinically important differences in QOL were defined in eight trials (23%), with results included in the abstract in 37% and article in 86%. Compliance was reported in 26 trials (74%), with 13 trials (37%) reporting specifically how they dealt with missing data. Only seven trials reported the reasons for missing data (20%).
Group results were published in 29 trials (83%), with 6 (17%) reporting individual patient results. Results were more commonly reported as a mean overall score (21 trials; 60%), with specific domain scores in only 9 trials (26%). No studies reported QOL beyond progression or included predefined context-specific endpoints based on objectives of treatment (i.e., palliation/cure/maintenance) and the patient population. Duration of benefit of palliative chemotherapy was reported in only one study.

Conclusion
Inclusion and reporting of QOL as a trial endpoint has improved in phase III trials in OC, but there are still significant shortfalls that need to be addressed in future trials.

Implications for Practice
The impact of treatment on quality of life (QOL) is an important consideration in patients with ovarian cancer for whom treatment is often given with palliative intent. Both the disease and treatment impact a patient's QOL and require careful evaluation in clinical trials. Matching the QOL questions to the patient population of interest is critical. Similar rigor to that used to assess progression-based endpoints is essential to guide clinical decisions. This systematic review demonstrated that although the inclusion and reporting of QOL as a trial endpoint has improved in phase III trials there are still significant shortfalls that need to be addressed in future trials.
Otoendoscopic management of small to medium sized tympanic membrane perforation
Authors: Showkat Showkat A. , Bhagat Nadhia , Bala Kiran , Yousuf Aamir 
Published: November 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Chronic suppurative otitis media (CSOM) is a wide spread disease of developing countries like India especially in rural areas. A perforated tympanic membrane results in loss of hearing due to decreased drum area and liability to recurrent infection of the middle ear mucosa. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A prospective study was conducted over a period of 18 months in the Department of ENT, HNS, Government Medical College, Srinagar with total of 36 patients were enrolled. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">This study consists of male 12 and 24 females mean age 32 yrs hearing loss average 26 db. Management methods were grouped in group A, B, C and D fat myringoplasty, chemical cauterization (trichloroacetic acid), fat myringoplasty + chemical cauterization: and transcanal transtympanic myringoplasty using tragal perichondrium respectively with least success seen in group B 55% and 100% seen in group D. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Otoendoscopic management of small to medium sized TM perforations with different methods is a cost effective, less traumatic procedure, cosmetically better and functionally effective in terms of hearing improvement.</span></p><p> </p>
IBADAH RITUAL DALAM MENANAMKAN AKHLAK REMAJA
Authors: Kastolani Kastolani 
Published: November 2017

This article explained what was viewed as ritual worship; pray and fasting to embed noble character. The purpose of worship in Islam are: (a) to strengthen belief and dedication to Allah; (b) to strengthen character, disciplining personality and his role as the agent trusted by Allah on earth; (c) to strengthen friend ship and affection among Muslim; (d) to train spiritual and moral. Character occupies crucial role in human’s life, as individual as well as society member. It is because the fall and raise of the nation depends on how its society character. The whole of worship system in Islam has close relation with character founding and the performance of ritual worship influences noble character, because good worship performance without having noble character will not useful.
Crescimento urbano de Sabará [MG]: modificação e conservação da cidade segundo seus instrumentos legais de planejamento
Authors: Silva Jaqueline Pugnal da 
Published: November 2017

Este artigo busca discutir a atuação das normas de regularização do território frente ao desenvolvimento urbano, em área que apresenta um preexistente diferenciado por suas características históricas e urbanísticas. Visando desenvolver uma investigação acerca do planejamento urbano, a cidade mineira de Sabará será o foco da análise deste artigo. Isso por dois motivos a priori: primeiro por se tratar de uma área diferenciada, apresentando edificações protegidas por tombamento realizado pelo Instituto do Patrimônio Histórico e Artístico Nacional - Iphan, e outrastombadas a nível municipal; e segundo, pelo fato de Sabará estar inserida na Região Metropolitana de Belo Horizonte, e por estar muito próxima da capital mineira. Neste contexto de intenções, este artigo se desenvolve a partir da realização de revisão bibliográfica de dimensão histórica, buscando, duplamente, uma compreensão da dinâmica urbana da cidade de Sabará e uma compreensão de sua passagem no tempo, particularmente as alterações ocorridas em seu território envolvente. Associadas, as duas perspectivas contribuirão na análise das normas em vigor, e no entendimento do papel exercido pelas mesmas na articulação das tendências de modificação e de conservação da cidade de Sabará.