bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing sleep problems using non-prescription medications and the role of community pharmacists: older adults’ perspectives
Authors: Abraham Olufunmilola , Schleiden Loren J , Brothers Amanda L , Albert Steven M 
Published: March 2017

Abstract

Objectives
To examine older adults’ perspectives regarding managing sleep problems through selection and use of non-prescription sleep aids, and the role of pharmacists.

Methods
Telephone interviews were conducted from May to June 2015 with 116 individuals aged ≥60 years in Pittsburgh, Pennsylvania. Participants reported in a previous survey to have used at least one non-prescription sleep aid in the past 30 days and were willing to participate in a follow-up interview. Interview guides were designed to elicit perspectives of sleep problems, selection and use of non-prescription sleep aids, and consultation with healthcare professionals. Interview transcripts underwent content analysis.

Key findings
Four themes emerged as follows: experiences with sleep problems, selection of non-prescription sleep aids, non-prescription sleep aid use and interactions with healthcare professionals. Over half of participants reported using a non-prescription sleep aid for &gt;1 year, were satisfied with its use and perceived it improved sleep quality. Participants commonly used an antihistamine-only sleep aid; 36% of participants self-recommended their sleep aid; and 16% of participants consulted healthcare professionals. Few participants read medication dosage labels (22%), side effects or warnings (19%), and many reported they disregarded directions. Participants did not typically consult pharmacists about sleep problems (65%) but perceived that they could assist with medication concerns.

Conclusions
Although most participants had favourable perceptions of non-prescription sleep aids, older adults may be inappropriately using non-prescription sleep aids to self-manage sleep problems by frequently disregarding medication labels and directions for safe use. Also, few older adults are discussing their sleep aid selection and use with pharmacists.
The importance of patient‐centred care to overcome barriers in the management of actinic keratosis
Authors: Cerio R. 
Published: March 2017

AbstractVisible actinic keratosis (AK) lesions and subclinical (non‐visible) sun damage in the field of cancerization are associated with risk of both non‐melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and, more rarely, melanoma. As the incidences of AK and skin cancer are increasing, effective prevention and treatment of AK is essential to minimize disease burden and improve patient quality of life. Currently, AK lesions are often left untreated and field therapies are underused. Patient‐centred care, with a focus on the patient‐physician relationship, has proven cost‐effective, and improved clinical outcomes and patient satisfaction in a number of therapy areas. Strategies for applying patient‐centred care to AK are warranted. Existing barriers to the effective treatment of AK were identified and patient‐centric strategies to overcome each barrier were discussed. Barriers to effective AK treatment include poor disease awareness (for both patient and physician), concerns associated with the cosmetic effects of treatment, treatment‐related side effects, cost perceptions for lesion‐directed vs field‐directed therapies, and inadequate adherence, particularly with long treatment duration. Overcoming these barriers will involve patient and physician education that promotes: disease prevention and awareness; the importance of self‐examination; an understanding of treatment options; and the importance of adherence to treatment. To maximize its effectiveness, education should be delivered within a patient‐centric framework, where the relationship between patient and physician is built on effective communication, empathy and a feeling of partnership. Patient‐centric care, including patient education, is key to overcoming the barriers associated with effective AK treatment.
Fatal pulmonary acariasis in an aged indoor rhesus macaque (Macaca mulatta)
Authors: Johnson AL , Simonek GD , Keesler RI 
Published: March 2017

AbstractPulmonary acariasis is a sporadic, incidental finding in colony‐raised rhesus macaques (Macaca mulatta). Prophylactic treatment in indoor‐raised and indoor‐housed macaques is not routine due to low prevalence, lack of clinical significance, and potential risk of toxicosis. This case is an unusually severe infestation of Pneumonyssus simicola in an indoor‐housed rhesus macaque, which ultimately resulted in this animal's death.
Recognizing Dementia: Constructing Deconstruction in a Danish Memory Clinic
Authors: Gjødsbøl Iben M. , Svendsen Mette N. 
Published: March 2017

AbstractThis article investigates how a person with dementia is made up through intersubjective acts of recognition. Based on ethnographic fieldwork in a Danish memory clinic, we show that identification of disease requires patients to be substituted by their relatives in constructing believable medical narratives; yet during memory testing, patients are not allowed any substitution to clearly expose cognitive shortcomings. In combining works of theorists Ian Hacking and Paul Ricoeur, we argue that the clinical identification of dementia unmakes the knowing subject, a deconstruction that threatens to misrecognize and humiliate the person under examination. The article ends by proposing that dementia be the condition that forces us to rethink our ways of recognizing persons more generally. Thus, dementia diagnostics provide insights into different enactments of the person that invite us to explore practices of substitution and modes of interaction emerging when our fundamental dependency becomes unquestionable.
Fever and prodromal infections in anti‐glomerular basement membrane disease
Authors: Gu Qiu‐hua , Xie Li‐jun , Jia Xiao‐yu , Ma Rui , Liao Yun‐hua , Cui Zhao , Zhao Ming‐hui 
Published: March 2017

AbstractAimAnti‐glomerular basement membrane (GBM) disease is an autoimmune disorder with rapidly progressive glomerulonephritis and alveolar haemorrhage. Fever symptoms and prodromal infections have been reported in many cases, but still not been elucidated.MethodsOur study enrolled 140 consecutive patients with anti‐GBM disease and retrospectively analyzed the characteristics of fever symptoms and the possible reasons.ResultsAmong the 140 patients, 94 (67.1%) patients presented with fever (over 37.5°C) prior to admission or within 48 h of hospitalization. Among those with fever, 74 (78.7%) patients had infections, 15 (16.0%) patients had positive serum anti‐neutrophil cytoplasmic antibodies, all towards myeloperoxidase, which was comparable to the patients without fever (17.4%, P = 0.830). There were 93/140 patients suffered from infections, with 47.3% in lungs and 31.2% on upper respiratory tract. In some cases, we identified the microbes of infections, including Candida albicans, Escherichia coli, Acinetobacter baumannii, Enterococcus faecalis, Klebsiella pneumoniae, Hemolytic staphylococci, Pseudomonas aeruginosa and Citrobacter braakii. Patients with fever had higher levels of serum anti‐GBM antibodies (154.9 ± 58.4 vs. 106.0 ± 63.2 IU/mL, P < 0.001), higher serum creatinine (733.4 ± 402.5 vs. 580.6 ± 368.1 μmol/L, P = 0.032), higher percentage of crescents (87.0 ± 15.6 vs. 67.4 ± 37.6%, P = 0.021), and higher frequency of progression to end stage renal disease (ESRD) (80.9% vs. 60.9%, P = 0.011).ConclusionWe concluded that fever is a common symptom in anti‐GBM disease and associates with more severe glomerulonephritis. The majority of patients at presentation had fever with respiratory tract infections, which needs further investigation to reveal their role in the pathogenesis of anti‐GBM disease.
Vida, arquitectura y pleitos en dos clausuras virreinales de Lima, Perú: Las Descalzas de San José y Santa Clara (siglos XVII-XXI)
Authors: Scaletti Cárdenas Adriana N. 
Published: March 2017

En este trabajo se presentan dos monasterios de clausura de la ciudad de Los Reyes de Lima: Las Descalzas de San José y Nuestra Señora de la Peña de Francia, coloquialmente llamado Santa Clara. Ambos sirven como ejemplo para caracterizar la morfología arquitectónica tradicional de esta clase de conjuntos religiosos apenas comenzado el siglo XVII y durante los siguientes años del virreinato del Perú. Uno de los espacios típicos que se encuentran allí exclusivamente son las celdas residenciales de las monjas, objeto de particular interés de nuestro estudio en cuanto fueron ambientes construidos, codiciados, modificados, peleados –y poco estudiados desde la perspectiva física. Así, este trabajo utiliza documentos y fuentes primarias del Archivo Arzobispal de Lima, además de relevamientos y trabajo de campo para aproximarse al entendimiento del tema desde lo arquitectónico, tanto en cuanto a materialidad como en morfología, funcionalidad y manejo del espacio. El estudio parte de un proyecto más amplio que abarca un sector importante de la Lima tradicional; apunta, además, a contribuir en la creación de conocimiento para la conservación de conjuntos religiosos similares en la ciudad.
Una aproximación a los orígenes de sitios con relevancia colonial de la región pampeana argentina mediante el análisis de los escudos locales
Authors: Aylén Enrique Laura 
Published: March 2017

En este trabajo nos preguntamos acerca de los modos en que se narra el pasado y el tipo de pasados que son legitimados desde ámbitos estatales en relación con una serie de sitios de relevancia durante el periodo colonial tardío. Nos centramos en la región pampeana argentina y estudiamos los casos de las actuales localidades de Macachín (provincia de La Pampa), Viedma (provincia de Río Negro), Carmen de Patagones, Mercedes y el partido de Tornquist (provincia de Buenos Aires). Nos propusimos analizar sus escudos locales con el objeto de indagar en la reconstrucción oficial del pasado colonial de estos lugares mediante los emblemas diseñados para representarlos.
Genome Editing in Clostridium saccharoperbutylacetonicum N1-4 with the CRISPR-Cas9 System
Authors: Wang Shaohua , Dong Sheng , Wang Pixiang , Tao Yong , Wang Yi 
Published: March 2017

ABSTRACT

Clostridium saccharoperbutylacetonicum
N1-4 is well known as a hyper-butanol-producing strain. However, the lack of genetic engineering tools hinders further elucidation of its solvent production mechanism and development of more robust strains. In this study, we set out to develop an efficient genome engineering system for this microorganism based on the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated 9 (CRISPR-Cas9) system. First, the functionality of the CRISPR-Cas9 system previously customized for
Clostridium beijerinckii
was evaluated in
C. saccharoperbutylacetonicum
by targeting
pta
and
buk
, two essential genes for acetate and butyrate production, respectively.
pta
and
buk
single and double deletion mutants were successfully obtained based on this system. However, the genome engineering efficiency was rather low (the mutation rate is <20%). Therefore, the efficiency was further optimized by evaluating various promoters for guide RNA (gRNA) expression. With promoter P

J23119

, we achieved a mutation rate of 75% for
pta
deletion without serial subculturing as suggested previously for
C. beijerinckii
. Thus, this developed CRISPR-Cas9 system is highly desirable for efficient genome editing in
C. saccharoperbutylacetonicum
. Batch fermentation results revealed that both the acid and solvent production profiles were altered due to the disruption of acid production pathways; however, neither acetate nor butyrate production was eliminated with the deletion of the corresponding gene. The butanol production, yield, and selectivity were improved in mutants, depending on the fermentation medium. In the
pta buk
double deletion mutant, the butanol production in P2 medium reached 19.0 g/liter, which is one of the highest levels ever reported from batch fermentations.

IMPORTANCE
An efficient CRISPR-Cas9 genome engineering system was developed for
C. saccharoperbutylacetonicum
N1-4. This paves the way for elucidating the solvent production mechanism in this hyper-butanol-producing microorganism and developing strains with desirable butanol-producing features. This tool can be easily adapted for use in closely related microorganisms. As also reported by others, here we demonstrated with solid data that the highly efficient expression of gRNA is the key factor determining the efficiency of CRISPR-Cas9 for genome editing. The protocol developed in this study can provide essential references for other researchers who work in the areas of metabolic engineering and synthetic biology. The developed mutants can be used as excellent starting strains for development of more robust ones for desirable solvent production.
Can an Immune Checkpoint Inhibitor (Sometimes) Make Things Worse?
Authors: Sharon Elad 
Published: March 2017

Abstract
Champiat and colleagues suggest that a small subset of patients at their center treated with PD1/PDL1 inhibitors appear to exhibit hyperprogression of disease. This commentary goes over some limitations in their preliminary analysis, a possible mechanism to explain the phenomenon, and a means by which other investigators can attempt to validate and further characterize these results. Clin Cancer Res; 23(8); 1879–81. ©2017 AACR.
See related article by Champiat et al., p. 1920
Fluorinated N,N'-Diarylureas As Novel Therapeutic Agents Against Cancer Stem Cells
Authors: Kenlan Dasha E. , Rychahou Piotr , Sviripa Vitaliy M. , Weiss Heidi L. , Liu Chunming , Watt David S. , Evers B. Mark 
Published: March 2017

Abstract
Colorectal cancer is the second-leading cause of cancer-related mortality in the United States. More than 50% of patients with colorectal cancer will develop local recurrence or distant organ metastasis. Cancer stem cells play a major role in the survival and metastasis of cancer cells. In this study, we examined the effects of novel AMP-activated protein kinase (AMPK) activating compounds on colorectal cancer metastatic and stem cell lines as potential candidates for chemotherapy. We found that activation of AMPK by all fluorinated N,N-diarylureas (FND) compounds at micromolar levels significantly inhibited the cell-cycle progression and subsequent cellular proliferation. In addition, we demonstrated that select FNDs significantly increased apoptosis in colorectal cancer metastatic and cancer stem cells. Therefore, FNDs hold considerable promise in the treatment of metastatic colorectal cancer, through elimination of both regular cancer cells and cancer stem cells. Mol Cancer Ther; 16(5); 831–7. ©2017 AACR.
Clinical Significance of Wall Changes After Recanalization Therapy in Acute Stroke
Authors: Seo Woo-Keun , Oh Kyungmi , Suh Sang-il , Seol Hae Young 
Published: March 2017

Background and Purpose—
Owing to the excellent recanalization rate of endovascular treatment, new outcome predictors are required for patients with acute stroke, who have sufficient recanalization. In this study, the effects of recanalization therapy on occluded arteries in patients with acute stroke were investigated using high-resolution vessel wall imaging.

Methods—
Twenty-nine patients with stroke were included in the study. High-resolution vessel wall imaging was performed on patients with acute stroke and adequate postrecanalization results. We characterized the postrecanalization arterial wall changes as concentric enhancements and plaques and examined the associations of the postrecanalization changes with procedural factors and neurological outcomes.

Results—
The most frequent high-resolution vessel wall imaging finding was concentric enhancement, which was associated with thrombectomy procedural factors such as the number of procedures and the type of device. Concentric enhancements were associated with hemorrhagic transformation, whereas plaque was not associated with procedural details.

Conclusions—
The use of high-resolution vessel wall imaging after successful recanalization can provide information about postrecanalization arterial wall changes and clinical outcomes.
Thrombophilia risk is not increased in children after perinatal stroke
Authors: Curtis Colleen , Mineyko Aleksandra , Massicotte Patricia , Leaker Michael , Jiang Xiu Yan , Floer Amalia , Kirton Adam 
Published: March 2017

Key PointsThrombophilia in children with perinatal stroke is rare, with rates similar to those in the normal population. Routine testing in childhood is not indicated.
Skin reactions after radial cardiac catheterisation
Authors: Mars Christine , Livesy Carla , Kemp Ian , Stables Rod 
Published: March 2017

Objectives: To examine the efficacy and safety of a hydrophilic-coated radial sheath previously associated with inflammatory cutaneous reactions. Background: Hydrophilic sheaths have a role in reducing the observed incidence of radial artery spasm. Delayed cutaneous inflammatory reactions have been reported following the use of some hydrophilic coated sheaths. Methods: SACRED (Systematic Assessment of the Cook Radial ShEath Device) was a prospective, single-centre registry study. The primary outcome measure was the observed incidence of cutaneous reaction to 28 days. Secondary outcome measures included: procedural success rate with the study sheath; rate of use of intra-arterial vasodilator agents; and the incidence of adverse events related to the access site during the index admission. A total of 431 patients were recruited. Results: Follow-up was completed in 429/433 (99.1%) radial sites instrumented with the study sheath. A single incidence of a delayed inflammatory skin reaction was observed (1/429; 0.23%) (95% confidence interval 0–0.68%). Failure to access the radial artery occurred in 19/446 attempts (4.3%). Overall, accessrelated intra-arterial vasodilator use was low at 83/433 (19.2%); routine, prophylactic use accounted for 70/83 (84.3%). The majority of operators were non-routine users but gave vasodilators in response to radial artery spasm in 13/363 (3.6%) of cases. Access site-related complications were minor and occurred in 33/446 (7.4%) of radial sites. Before discharge from the index procedure, radial artery occlusion was observed in 15/412 (3.6%). Conclusions: A single, self-limiting lesion suggested granuloma but without histological confirmation. Access success rates were comparable with other studies but with non-routine use of vasodilators. Radial artery occlusion at discharge was associated with older age, lower body weight and a failure to anticoagulate.
Process of technology management in SMEs of the metal processing industry – the case study investigation
Authors: Krawczyk-Dembicka Elżbieta 
Published: March 2017

Abstract
The main purpose of this work is to identify the factors that influence the process of technology management in the sector of small- and medium-sized enterprises of the metal processing industry, considering the shape and course required to achieve modern operation conditions by enterprises in the market.
The research process used the case study method, which was preceded by study visits to manufacturing enterprises, direct interviews with representatives of the management and employees of enterprises, and observations of the processing conditions.
The result of the research was the identification of technologies available and used in the analysed enterprises. It defines the process of technology management as well as the internal and external factors influencing this process and defines the timeline for the process of technology management.
The obtained results are the effect of the preliminary research, whose outcome will result in the development of issues related to technology management. They will be used to create a model of technology management, the assumptions of which will respond to modern needs and possibilities of manufacturing enterprises of the metal processing industry. The model can be used for practical application aimed at the provision of enterprises with innovation and competitiveness in the domestic and foreign markets.
Velocity Controller for a Class of Vehicles
Authors: Herman Przemyslaw , Adamski Wojciech 
Published: March 2017

Abstract
This paper addresses the problem of velocity tracking control for various fully-actuated robotic vehicles. The presented method, which is based on transformation of equations of motion allows one to use, in the control gain matrix, the dynamical couplings existing in the system. Consequently, the dynamics of the vehicle is incorporated into the control process what leads to fast velocity error convergence. The stability of the system under the controller is derived based on Lyapunov argument. Moreover, the robustness of the proposed controller is shown too. The general approach is valid for 6 DOF models as well as other reduced models of vehicles. Simulation results on a 6 DOF indoor airship validate the described velocity tracking methodology.
Seven-Port Unequal Power Divider with Broadband and Large Division Ratio Characteristics Based on T-shape Stub
Authors: Jiang Xing , Wei Jia , Peng Lin , Tang Shao-Yu 
Published: March 2017

AbstractA broadband seven-port unequal power divider with large division ratio is designed based on the technique of T-shape stub. A T-shape stub is introduced to replace the conventional design for high characteristic impedance line in realization due to very small line width. The theoretical basis of the proposed T-shape stub is analyzed in detail using the Method of Matrix Algebra Analysis. The proposed design is simulated, fabricated and measured. The measured results are in good agreement with the simulated ones, and a large division ratio of 1:6 is achieved. The operation bandwidth of the proposed design is about 12 % (from 4.8 to 5.4 GHz).
Study regarding team statistics at the last three men’s basketball World Championship
Authors: Petreanu Adrian Gheorghe , Petreanu Manuela 
Published: March 2017

Abstract
Achieving superior performance parameters in major competitions has highlighted a number of issues that characterize the current basketball game practiced by the best teams in the world. Depending on the height, role, importance and the effectiveness of players on their positions, specific models are to be observed in the case of senior teams [1].
In this paper we present a comparative study regarding the parameters’ models in the men's basketball games during the World Championships in Japan - 2006, in Turkey - 2010 and in Spain - 2014. Along with data interpretation, we tried to effectively bring our scientific contribution in shaping a model significant for the international basketball games, useful for the specialists in the field. Centralization of the statistical data used in our study was useful in calculating the averages for each game parameter and the increasing value for each tournament, managing to achieve a precise statistical comparison. The values encountered in this comparative research showed growth or regression trends for the game parameters.
In conclusion, trends of progress or regress, referring to the statistical model parameters involved in the game, pragmatically showed, that in the game of basketball – training is the key to success.