bluuebunny/crossref_metadata_2025_split huggingface dataset:
KNOWLEDGE AND ATTITUDE WITH ADHERENCE TO FE TABLET CONSUMPTION IN ANEMIC ADOLESCENT GIRLS
Authors: Diani Aisyah Amalia Putri , Amalia Rize Budi , Sudaryanti Lestari , Lestari Pudji 
Published: October 2024

Background: Iron anemia could be prevented through the administration of Fe tablets (TTD). Several studies had shown that one of the obstacles often encountered in the Fe tablet administration program was the problem of compliance. The low compliance of Fe tablets consumption in adolescent girls was influenced by several factors, one of which was the knowledge of female students regarding the benefits of consuming Fe tablets. Knowledge affected the attitudes and behavior of adolescents in choosing food, consuming Fe tablets supplementation, and further affected the overall nutritional condition of individuals including the condition of anemia status. Objective: This study aimed to demonstrate the connection between attitudes and knowledge about adherence to Fe tablets use in anemic adolescents at Pondok Pesantren Mambaus Sholihin, Gresik District, East Java. Methods: This type of research was quantitative research with a cross-sectional design, sampling using the total sampling method. Method in this research was an analytical observational study with a cohort retrospective design. The samples in this study were 81 adolescent girls aged 15-17 years who experienced anemia. The variables used in this study were knowledge, attitude and compliance. The instruments used were questionnaires and checklist forms. Compliance with Fe tablet consumption was carried out for the last 3 months. Results: Most respondents had sufficient knowledge related to anemia and Fe tablets around (31.1%) and most responders had a positive attitude of (56.8%) most respondents were not compliant with the consumption of Fe tablets by (58.0%). After the chi square test, the significance value (p=0.002) was obtained, which means that statistically there is a significant relationship between knowledge and Fe tablet consumption, and (p=0.000) there is a significant relationship between attitude and Fe tablet consumption. Conclusion: The study concluded that among teenage girls attending the Mambaus Sholihin Islamic Boarding School, there was a relationship between knowledge and attitude regarding the intake of Fe tablets.
In vitro study of the gel cohesivity and persistence to hyaluronidase degradation of a novel stabilized composition of 26 mg/mL of high molecular weight HA
Authors: Finke Alexandre , Betemps Jeremie Bon , Molliard Samuel Gavard 
Published: October 2024

Aim: Hyaluronic acid (HA) is extensively used in injectable skin quality products due to its documented role in skin rejuvenation. The rapid in vivo degradation of HA by the enzyme hyaluronidase necessitates the development of advanced formulations to ensure the efficacy and longevity of the treatments. In this context, a novel 2.6% high molecular weight HA (H-HA)/3.2% sorbitol composition has been introduced, featuring stabilization through hydrogen bonds rather than traditional crosslinking.
Methods: The stabilized composition was evaluated through two in vitro enzymatic degradation tests. In the first test, the efficiency on the gel degradation was followed by rheology and compared with two crosslinked HA products available on the market. In the second test, the effect on the gel structure of a less diluted hyaluronidase dose was followed by rheological and cohesivity measurements.
Results: In vitro study demonstrates that, before its complete degradation into a liquid-like state, the stabilized composition exhibits high elasticity and cohesivity during the enzymatic degradation process, surpassing traditional crosslinked HA products.
Conclusion: The stabilization provided by the sorbitol in the stabilized composition effectively enhances product properties and protects them during gel degradation. These attributes indicate significant potential for improved clinical outcomes in skin quality treatments.
A biopsychosocial analysis of risk factors for long-term physical, cognitive, and psychological functioning in previously hospitalized post-COVID-19 patients
Authors: Claessens Gisela , Gach Debbie , Osch Frits H.M. , Verberne Daan , Bergh Joop P van den , Boogaart Vivian van Kampen-van den , Beijers Rosanne J.H.C.G. , Schols Annemie M.W.J. , Balen Eric van , Heugten Caroline van 
Published: October 2024

Abstract

A significant number of COVID-19 survivors continue to experience persistent physical, cognitive, and psychological symptoms up to one year after discharge. This study aimed to examine the frequency, severity, and progression of these symptoms, along with contributing factors. This single-centre retrospective cohort study included 126 COVID-19 patients admitted to the VieCuri Medical Centre between 2020 and 2022, with follow-ups at 3 and 12 months post-discharge. Assessments involved pulmonary function tests, CT scans, bioimpedance analysis, and questionnaires on physical, cognitive, and psychological symptoms. At both follow-ups, 31–32% of patients reported moderate to severe physical symptoms, 26–27% reported multiple cognitive symptoms, and 14–18% experienced depressive or post-traumatic stress symptoms (PTSS). Only anxiety symptoms significantly decreased from 22% at 3 months to 12% at 12 months (p = .014). Persistent symptoms at 12 months were significantly associated with premorbid conditions (chronic respiratory disease, multiple comorbidities), injury severity (infection during the third wave), physical factors (COVID-related pulmonary abnormalities, lower total lung capacity, dyspnoea), and cognitive and psychological factors (cognitive symptoms, anxiety, depression, and PTSS) (p < .05). These findings suggest that a significant portion of COVID-19 survivors continue to experience persistent symptoms influenced by biopsychosocial factors, emphasizing the need for a biopsychosocial approach in early screening and treatment.
Developing Computer Vision and Machine Learning Strategies to Unlock Government-created Records
Authors: Jansen Greg , Marciano Richard 
Published: October 2024

Abstract

This work explores the development of AI and ML computer vision techniques to unlock digitized handwritten US Census records from the 1950s, which includes over 6.5 million images and was only recently made available to the public on April 1, 2022, following a 72-year access restriction period. The 1950 Census offers a unique window "into one of the most transformative periods in modern American history, revealing a country of roughly 151 million people who had just recently emerged from the hardships and uncertainties of World War II and the Great Depression." (census.gov).
This computer vision and machine learning work is part of a larger case study based in Sacramento, California focusing on creating a so-far unseen window into the fate of the Japanese American community. Sacramento once housed the fourth largest Japantown community on the West Coast and saw its community forced out twice in a decade: in 1942 during WWII Japanese American Incarceration (the largest single forced relocation in US history), and in 1954 during urban renewal where Japantown residential and business districts were leveled. Our project uses AI-based computational treatments to help recover and memorialize the history of the erased Sacramento Japantown. Moreover, we contrast these findings with the processing of the 1940 Census (released in 2012), thus producing a novel "before-and-after" representation.
We demonstrate a workflow for extracting demographic information using image segmentation, computer vision techniques, and deep learning for handwritten character recognition. These techniques are generalizable to other cities, states, and communities, and demonstrate AI-assisted strategies to unlock vital demographic information. The approach highlights the potential benefits of computational techniques on social justice issues.
The workflow represents an AI-assisted filtering process for Census records, with a user interface for computationally driven page review. The goal is to automate the culling of pages to select a smaller subset of pages that can then be further targeted or crowdsourced.
Mouse Brain Atlas of Dendritic Microenvironments Identifies Associations of Anatomy, Projection Targets and Transcriptomic Profiles of Neurons
Authors: Peng Hanchuan , Liu Yufeng , Zhao Sujun , Yun Zhixi , Xiong Feng 
Published: October 2024

Abstract

Digital brain atlases have become essential anatomical references for understanding the spatial and functional organization of brains. For mice, typical resources include the Allen Reference Atlas, the Allen Common Coordinate Framework (CCF), and their variants, like CCFv3. However, previous whole-brain atlases were constructed based on limited neuronal features, such as cell body (soma) density or average maps from collections of registered brain images, without considering the spatial organization of neuronal arbors. This study introduces a microenvironment representation that incorporates the morphological features of neighboring neurons to better quantify brain modularity. We generated a large dataset containing dendrites from 101,136 neurons across 111 mouse brains, covering 91% of non-ventricular, non-fiber-tract CCF regions, and constructed a multidimensional microenvironment feature map of the whole brain. Our findings reveal that the spatial organization of these microenvironments outperforms the CCFv3 and a state-of-the-art spatial transcriptomic cell atlas by providing complementary subregions within established regions, nearly doubling the total number of brain regions compared to CCFv3. In this way, our atlas enables the identification of previously unobserved neuron groupings or “subtypes”. Our results also demonstrate that this microenvironment atlas enhances local spatial homogeneity while maintaining spatial differentiation within established CCF brain regions. For example, we found that the microenvironments of hippocampal neurons are correlated with axonal projection targets and improve the specificity of projection mapping, which implies the potential characterization of long-range axonal projections of mammalian neurons based on only local dendritic organization. The sub-parcellation of the caudoputamen (CP) aligns well with previous studies on projections, connectivity, and transcriptomics, revealing diverse input and output wiring patterns among CP subregions.
Low expression of Proto-Oncogene FOS regulated by LINC00667/ LINC00921-miR-34a-5p axis correlates with poor prognosis and restrained anti-tumor immunity in human breast cancer
Authors: Xu Hui , Li Chouyang 
Published: October 2024

Abstract

The activator protein 1 transcription factor family member FOS has been demonstrated to play meaningful roles in multiple pathophysiological processes as well as in cancer. However, the prognostic value of FOS and its underlying mechanisms in cancer progression have not been fully illuminated. In this study, the pan-cancer expression level of FOS was first assessed and the expression discrepancy of FOS in multiple cancer types was confirmed. Then, survival analysis for multiple cancer types demonstrated that low FOS expression significantly correlated with poor prognosis in breast cancer (BRCA). Further, the expression profile of FOS in BRCA patients with different clinicopathological features was analyzed and lower FOS expression was found to correlate with more severe BRCA features, which verified the roles of FOS in BRCA progression. Subsequently, noncoding RNA (ncRNA) in the regulation of FOS expression in BRCA was explored, and a regulatory axis LINC00667/ LINC00921-miR-34a-5p was identified. Further, the correlation between FOS and immune micro-environment of BRCA was analyzed. We found that down-regulated FOS level was remarkably associated with high tumor purity, less anti-tumor immune cells and components, and high expression of immune checkpoints. In summary, our findings unveiled that down-regulated FOS mediated by LINC00667/ LINC00921-miR-34a-5p axis correlated with restrained anti-tumor immunity, and therefore leading to poor prognosis in BRCA.
Decoding health disparities: gender, ethnicity, &amp; chronic diseases in Latin Americans with individual data &amp; machine learning
Authors: Chivardi Carlos , Zamudio Alejandro , Cavalcanti Daniella , Ordoñez José , Almeida Cristina , Hessel Philipp , Moncayo Ana , Rasella Davide 
Published: October 2024

Abstract

Chronic diseases disproportionately affect ethnic and gender groups, yet the social determinants driving these disparities in Latin America are not fully understood. In this study, we analyzed data from 96,726,891 adults obtained from national health surveys in Brazil, Mexico, and Ecuador during 2018–2019. We employed random forest models to predict chronic disease diagnoses based on education, occupation, and access to essential services like sewage, piped water, and garbage collection. Our models performed best for indigenous and black individuals, underscoring significant inequities. Education emerged as a stronger predictor for women, while occupation was more influential for men. Specifically, removing education data reduced model performance for women by 59.6%, whereas removing occupation data reduced performance for men by 31.6%. These findings highlight the need for public policies tailored to the unique needs of different gender and ethnic groups—promoting improved employment opportunities for men, enhanced educational access for women, and better housing conditions for indigenous and black populations.
Safety of infliximab and adalimumab in pediatric inflammatory bowel diseases: a real-world analysis from FAERS database
Authors: DENG Yanhong , Shi Shengying , Feng Senling , Tan Xiangping , Wang Yinling , Yin Jinjin , Gao Yuanmei , Liu Shaozhi 
Published: October 2024

Abstract

The incidence of pediatric inflammatory bowel disease (IBD) has significantly increased over the past few decades. Infliximab (IFX) and adalimumab (ADA) are the only two Tumor necrosis factor-α (TNF-α) inhibitors that have been approved by the FDA for the treatment of IBD in pediatric patients. However, postmarketing pharmacovigilance of the two TNF-α inhibitors in pediatric IBD is not sufficient and requires ongoing vigilant attention. We aimed to evaluate the safety of IFX and ADA in pediatric IBD using data from FAERS database. We filtered the queries within FAERS database to specifically identify indications of IBD among patients under the age of 18 from the first quarter of 2004 to that of 2024. Reporting odds ratio (ROR) and proportional reporting ratio (PRR) algorithnms were used to identify drug-adverse event associtions. A total of 15, 955 reports of adverse events (AEs) caused by IFX and ADA as the primary suspect (PS) for pediatric IBD were extracted from FAERS database. We detected 95 positive signals of IFX involved in 17 system organ classes (SOCs) and 165 positive signals of ADA involved in 20 SOCs. The most commonly reported AEs for IFX were related to infusion reactions, whereas the predominant AEs for ADA involved injection site reactions. The majority of our detected AEs were disclosed on the product labell; however, certain AEs, including attempted suicide, increased weight, and psoriasis for IFX, as well as suicidal depression for ADA, were not listed. The median time to onset of IFX-related AEs was 579 days (interquartile range [IQR] 159.25–1357 days), with the majority occurring after 360 days initiation of IFX. While the median time to onset of ADA-related AEs was 79 days ([IQR] 21.75–295 days), with the majority occurring within 90 days after initiation of ADA. We conducted a comprehensive assessment and comparison of the safety of IFX and ADA for treating pediatric IBD, using real-world data from the FAERS database. Our study emphasizes the importance for medical practitioners to closely monitor AEs that may result in serious outcomes and are not listed in the labeling, thereby ensuring the safety of IFX and ADA treatments for children with IBD.
HMMR is an independent prognostic indicator in neuroblastoma and loss of HMMR suppresses cell proliferation, migration and clonogenicity.
Authors: Karapouliou Christina , Rajeeve Vinothini , Cutillas Pedro , stoker andrew 
Published: October 2024

Abstract

Purpose
Neuroblastoma is a childhood cancer with poor survival rates. Approximately 75% of tumours have no identified oncogenic driver and here our aim was for the first time to investigate whether HMMR, a protein with hyaluronic acid (HA)-binding properties, nuclear actions, and oncogene-like roles in other cancers, harbors similar potential roles in neuroblastoma cells.
Methods
We bioinformatically analysed patient survival data in relation to HMMRexpression, followed by CRISPR/Cas9-based disruption of HMMR in KELLY neuroblastoma cells. HMMR’s support of proliferation, motility and clonogenicity were analysed and the dependence on exogenous HA determined. Xenografted tumours with disrupted HMMR were analysed to assess animal survival characteristics. Lastly, phosphoproteomics was used to begin to define the biochemical actions of HMMR in these tumour-derived cells.
Results
High HMMRexpression is shown to be an independent prognostic indicator of poor survival in neuroblastoma patients. Furthermore, HMMR-deficient cells in culture have reduced proliferation, motility and clonogenic capacities compared to parental cells, and HA had variable ability to rescue these. Loss of HMMR also reduces xenografted tumour growth rates. Signaling downstream of MAPK1/2 and MTOR were both disrupted at a phosphoproteomic level after loss of HMMR, while the phospho-status of DNA damage response (DDR) proteins was significantly enhanced.
Conclusion
This study indicates that high HMMR expression could be a new and potentially useful prognostic marker of poor neuroblastoma survival. Moreover, HMMR has oncoprotein-like properties in neuroblastoma cells, with some actions being HA-regulated. The study also reveals the first data that may implicate HMMR in MTOR and DDR regulation.
Self inserted foreign body in bladder of a male patient : complications and management.
Authors: Ahmad Ali , Shabbir Muhammad Usama Bin , Tariq Abdullah , Javeriya Sana , Khan Kamran 
Published: October 2024

Abstract

We document the case of a 28-year-old male who presented with frequent UTI and lower urinary tract symptoms including haematuria resulting from a self-inflicted intravesical foreign body. The patient underwent diagnostic evaluation, including a kidney-ureter-bladder (KUB) X-ray and ultrasound (USG), which confirmed the presence and location of the foreign object within the bladder. Due to the size and positioning of the object, an open cystectomy was performed to safely remove it. Postoperative recovery was uneventful. We discharged the patient with recommendations for psychiatric evaluation to address potential underlying behavioural or psychological issues associated with self-inflicted injuries. This case reflects the need for a multidisciplinary approach in managing similar presentations, combining surgical intervention with psychological support.
Missense variants in homeobox domain of PBX1 cause coracoclavicular ankylosis
Authors: Kurosawa Kenji , Iwai Maki , Stuurman Kyra , Meagher Kirsten , Leveille Lise , Saisu Takashi , Mori Satomi , Kumaki Tatsuro , Enomoto Yumi , Aida Noriko , Suzuki Hisato , Takenouchi Toshiki , Kosaki Kenjiro , Patel Millan , Nishimura Gen 
Published: October 2024

Abstract

There have been several reports on heterozygous loss of function variants in PBX1 associated with congenital anomalies of the kidney and urinary tract (CAKUT). We report three patients harboring de novo heterozygous missense variants in PBX1, who did not have CAKUT, but instead presented with respiratory failure, developmental delay, and, the most important, a unique skeletal phenotype characterized by broad and short clavicles with coracoclavicular ankylosis and broad ischia with premature fusion of the ischiopubic synchondrosis. All the variants are clustered at the last portion of the homeobox domain. These phenotypes are consistent with mouse models with functional dysregulation in Pbx1 or its interacting factor, Emx2. This study reports a novel phenotype affecting the clavicle and ischia due to PBX1 variants and expands the clinical spectrum of PBX1-related disorder.
The influence of suturing and/ gluing of perforated Schneiderian membrane during sinuslift procedure on the outcome- a retrospective study
Authors: Khoury Fouad , Schmidt Christoph , Jackowski Jochen 
Published: October 2024

Abstract

The sinus lift procedure has become the most common method for maxillary bone augmentation. The most frequently observed intraoperative complication is the perforation of the Schneiderian membrane. Various treatment options have been proposed for managing these perforations, including the use of resorbable membranes, centrifugated blood products as PRF, or PRGF, suturing, and fibrin glue application. While long-term studies exist for the use of resorbable membranes to close perforations, there is limited data on the long-term outcomes of suturing or gluing the perforated sinus membrane.
The aim of this retrospective study is to evaluate the long-term outcomes of suturing and/or applying fibrin glue to repair perforated sinus mucosa during sinus floor elevation procedures. Between 2005 and 2009, a total of 692 patients underwent 923 sinus lift surgeries, and Schneiderian membrane perforation occurred in 202 sinus floor elevations (21.98%) across 168 patients. The main documented causes of perforations, which ranged from 2 to 10 mm in diameter, were the presence of septa, followed by thin and adherent membranes. Of the perforations, 100 (49.5%) were treated with microsurgical suturing combined with fibrin glue, 78 (38.6%) were treated with fibrin glue alone, and 24 (11.9%) were treated exclusively with suturing.
Sinus grafting was performed using autogenous bone in combination with a biomaterial, following the layering technique. All surgeries resulted in primary healing without complications, enabling all patients to undergo restoration as planned. The long term clinical and radiological evaluations of 44 randomly selected patients who followed the recall program up to 10 years post operative confirmed the effectiveness of this treatment approach.
Sleep and Risk of Peptic Ulcer Disease: a cross-sectional study
Authors: Ren Qian , Gao Jie , Li Bowen , Luo Xiu , Zhao Guangyuan , Zheng Ya , Yang Fucheng , Ji Rui , Guo Qinghong , Chen Zhaofeng , Wang Yuping , Lu Hong , Zhou Yongning 
Published: October 2024

Abstract

BACKGROUND & AIMS：The association between sleep duration and gastrointestinal disorders has been investigated extensively, but the specific link with peptic ulcer disease (PUD), including gastric ulcer (GU) and duodenal ulcer (DU), has not been thoroughly examined. Our objective was to assess the relationship between sleep duration and the occurrence of PUD, GU, and DU.
METHODS: We undertook a cross-sectional analysis involving 4,860 individuals from the Wuwei cohort. Participants' daily sleep duration was assessed by inquiring about the number of hours slept per day. Odds ratios and 95% confidence intervals were calculated using binary logistic regression.
RESULTS: In age- and sex-adjusted logistic regression analyses, those who slept > 9h were less likely to develop GU compared to those who slept 7-9h. (OR = 0.67, 95% CI= 0.55-0.80) , but had an increased risk of developing DU (OR = 1.39, 95% CI=1.10-1.77).This result remains significant in Model 2.
CONCLUSIONS: Prolonged sleep associated with gastric ulcer and duodenal ulcer disease