bluuebunny/crossref_metadata_2025_split huggingface dataset:
UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation
Authors: Suzuki Rigel , Kawahara Hiroyuki 
Published: April 2016

AbstractThe majority of transmembrane proteins are integrated into the endoplasmic reticulum (ER) by virtue of a signal sequence‐mediated co‐translational process. However, a substantial portion of transmembrane proteins fails to reach the ER, leading to mislocalized cytosolic polypeptides. Their appropriate recognition and removal are of the utmost importance to avoid proteotoxic stress. Here, we identified UBQLN4 as a BAG6‐binding factor that eliminates newly synthesized defective polypeptides. Using a truncated transmembrane domain protein whose degradation occurs during a pre‐ER incorporation process as a model, we show that UBQLN4 recognizes misassembled proteins in the cytoplasm and targets these to the proteasome. We suggest that the exposed transmembrane segment of the defective polypeptides is essential for the UBQLN4‐mediated substrate discrimination. Importantly, UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle. This study identifies a novel quality control mechanism for newly synthesized and defective transmembrane domain polypeptides that fail to reach their correct destination at the ER membrane.
An inter‐species protein–protein interaction network across vast evolutionary distance
Authors: Zhong Quan , Pevzner Samuel J , Hao Tong , Wang Yang , Mosca Roberto , Menche Jörg , Taipale Mikko , Taşan Murat , Fan Changyu , Yang Xinping , Haley Patrick , Murray Ryan R , Mer Flora , Gebreab Fana , Tam Stanley , MacWilliams Andrew , Dricot Amélie , Reichert Patrick , Santhanam Balaji , Ghamsari Lila , Calderwood Michael A , Rolland Thomas , Charloteaux Benoit , Lindquist Susan , Barabási Albert‐László , Hill David E , Aloy Patrick , Cusick Michael E , Xia Yu , Roth Frederick P , Vidal Marc 
Published: April 2016

AbstractIn cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical‐versus‐functional network coordination is shaped by evolutionary forces are all largely unanswered questions. Here, we investigate these questions using an “inter‐interactome” approach. We systematically probed the yeast and human proteomes for interactions between proteins from these two species and functionally characterized the resulting inter‐interactome network. After a billion years of evolutionary divergence, the yeast and human proteomes are still capable of forming a biophysical network with properties that resemble those of intra‐species networks. Although substantially reduced relative to intra‐species networks, the levels of functional overlap in the yeast–human inter‐interactome network uncover significant remnants of co‐functionality widely preserved in the two proteomes beyond human–yeast homologs. Our data support evolutionary selection against biophysical interactions between proteins with little or no co‐functionality. Such non‐functional interactions, however, represent a reservoir from which nascent functional interactions may arise.
Pooled‐matrix protein interaction screens using Barcode Fusion Genetics
Authors: Yachie Nozomu , Petsalaki Evangelia , Mellor Joseph C , Weile Jochen , Jacob Yves , Verby Marta , Ozturk Sedide B , Li Siyang , Cote Atina G , Mosca Roberto , Knapp Jennifer J , Ko Minjeong , Yu Analyn , Gebbia Marinella , Sahni Nidhi , Yi Song , Tyagi Tanya , Sheykhkarimli Dayag , Roth Jonathan F , Wong Cassandra , Musa Louai , Snider Jamie , Liu Yi‐Chun , Yu Haiyuan , Braun Pascal , Stagljar Igor , Hao Tong , Calderwood Michael A , Pelletier Laurence , Aloy Patrick , Hill David E , Vidal Marc , Roth Frederick P 
Published: April 2016

AbstractHigh‐throughput binary protein interaction mapping is continuing to extend our understanding of cellular function and disease mechanisms. However, we remain one or two orders of magnitude away from a complete interaction map for humans and other major model organisms. Completion will require screening at substantially larger scales with many complementary assays, requiring further efficiency gains in proteome‐scale interaction mapping. Here, we report Barcode Fusion Genetics‐Yeast Two‐Hybrid (BFG‐Y2H), by which a full matrix of protein pairs can be screened in a single multiplexed strain pool. BFG‐Y2H uses Cre recombination to fuse DNA barcodes from distinct plasmids, generating chimeric protein‐pair barcodes that can be quantified via next‐generation sequencing. We applied BFG‐Y2H to four different matrices ranging in scale from ~25 K to 2.5 M protein pairs. The results show that BFG‐Y2H increases the efficiency of protein matrix screening, with quality that is on par with state‐of‐the‐art Y2H methods.
La lingüística cognitiva: una aproximación al abordaje del lenguaje como fenómeno cognitivo integrado
Authors: Moreno Mojica Javier Aníbal 
Published: April 2016

<p>La lingüística cognitiva es un movimiento lingüístico que concibe el lenguaje como una capacidad integrativa dentro de las tareas cognitivas propias del hombre, lo que devela que el lenguaje está basado en procesos de cognición complejos tales como la percepción, conceptualización, categorización, inferencia, entre otros, los que de una u otra forma permiten una aprehensión, funcionamiento, estructuración y adecuación de la realidad y el mundo. No obstante, debido a sus postulaciones en contraposición de paradigmas lingüísticos tradicionales, ha sido señalada más de teoría unificada que de una corriente como tal, llegando a desconocerse no solo sus orígenes, preguntas fundamentales, principios teóricos y tareas propias, sino sus aportes a la ciencia lingüística en lo que atañe a la concepción y comprensión de la facultad del lenguaje humano. A través de este artículo se presenta una aproximación a la lingüística cognitiva en cuanto a su desarrollo histórico, constructos teóricos fundamentales y tendencias particulares en lo propio a la relación lenguaje-cognición-realidad.</p>
Más allá del color: proyecto etnoeducativo en la Institución Educativa Lorgia de Arco
Authors: Álvarez Mangones Jhame , Campo Polo Sandra Helena , Hoyos Pernett Ricardo 
Published: April 2016

<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>Más allá del color: proyecto etnoeducativo en la Instituición Educativa Lorgia de Arco, en Santander de la Cruz, municipio de Moñitos, es un trabajo de sistematización sobre la implementación del proceso etnoeducativo afrocolombiano según el decreto 804 de 1995, encaminado a la construcción colectiva de un proyecto global de vida como propuesta alternativa de desarrollo comunitario endógeno con participación de la comunidad en general. Con base en el enfoque epistemológico crítico social, este trabajo reconstruye un proceso étnico, social y pedagógico, basado en el empoderamiento legal y pedagógico de una comunidad que logró, a partir de talleres y prácticas de campo, construir poco a poco sus prácticas institucionales, etnoeducativas, estrategias pedagógicas y didácticas que permitieron apropiarse de un modelo didáctico ambiental fundamentado en ejes problémicos de identidad, cultura ambiental, calidad de vida y desarrollo comunitario, como un devenir social más allá del color, en la perspectiva de los derechos humanos </span><span>en contextos pedagógicos de acciones afirmativas. </span></p></div></div></div></div>
Clases de costura, tejidos y puntadas
Authors: Sosa Quintero Carol Dayana , Mejía Sánchez Claudia Patricia 
Published: April 2016

<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>Este artículo da cuenta de los ejercicios pedagógicos que en una perspec- tiva epistemológica construccionista han sido planteados desde la unidad de Humanidades y Formación Integral de la Universidad Santo Tomás, Villavicencio, tejiendo narrativas entre estudiantes, docentes y ciudadanos. Construidos en lenguaje simbólico-narrativo, facilitan una hermenéutica pe- dagógica orientada a la comprensión de cuentos, relatos y narraciones, que a su vez interrogan y trasforman la realidad de los participantes. Se desarrolla en parques, plazas, iglesias, barrios, avenidas y monumentos, espacios abiertos a diferentes formas creativas y lúdicas, en las que cobra sentido la recolección de los saberes ancestrales, experiencias de vida y fábulas urbanas, que hacen del caminar del estudiante universitario un costurero único, apasionante y formativo, y proporcionan herramientas para que los estudiantes se apasionen por otros textos, otras lecturas, incluido el diálogo con las comunidades, </span><span>cuyas experiencias y sueños apoyan esta reflexión pedagógica, invitándolos a </span><span>comunicarse y releer su mundo desde diversas perspectivas epistemológicas. </span></p></div></div></div></div>
Una mirada al performance de Orlan desde una lectura del CsO
Authors: Silva Salazar Steven 
Published: April 2016

<p>La obra de arte puede ser mirada, y es la perspectiva desde la que se construye este texto, como una forma de pensamiento, y en este contexto, como una forma de producción de la filosofía. Se trata de ver cómo el mismo objeto artístico se convierte en un fenómeno de interpretación de la vida, y así ofrece respuestas vitales a la misma cotidianidad, tanto del artista/creador como del espectador. El ejercicio surge con ocasión de la visita de la reconocida y polémica artista francesa Orlan al Museo de Arte Moderno de Bogotá, de forma que este artículo tiene como propósito hacer un acercamiento estético y filosófico al performance de la artista, desde sus inicios hasta sus últimas obras fotográficas, a través de la perspectiva de cuerpo sin órganos; concepto filosófico utilizado por G. Deleuze y F. Guattari (2000).</p>
Unique Haban wares from the Castle of Regéc
Authors: Pető Zsuzsa Eszter 
Published: April 2016

The Castle of Regéc, located in what is today Northeastern Hungary, is one of the largest fortresses built at the turn of the 13th and 14th century. The fortified castle has a complex history; in the post-mediaeval era, several noble and aristocratic families owned it (among others, the Alaghy, Mágóchy, Esterházy, and Rákóczi families). As the Haban wares became increasingly popular in the 17th century in the western, northeastern, and eastern areas of the Carpathian Basin, this type of ceramic can be found at Regéc as well.
Besides the numerous small potsherds and stove tiles, a plate and many fragments of a unique type of floor brick have been excavated. The latter two objects were selected for the present study, which will perhaps show that besides the traditional art historical analysis of ceramics stored in museums or private collections, it is just as important to make comparative studies to evaluate the historical archaeological material.
The present study gives an introduction to the selected material. The Haban plate, dated to 1659 by its inscription, is a unique piece; similar types can be found in some collections. The type of decorated floor bricks is possibly the only identified masterpiece of Haban craftsmen among those that have been found in the region.
The collection of Anabaptist (Hutterite) ceramics in the Moravian Museum in Brno
Authors: Kalinová Alena 
Published: April 2016

The Anabaptists, who started to settle in Moravia after 1526, brought with them the production of faience. They were concentrated mainly in the demesnes of Southern Moravia (current districts of Břeclav, Hodonín, Uherské Hradiště and Znojmo), but after 1620 as non-Catholics, the Anabaptists had to leave. They went mostly to the neighbouring Kingdom of Hungary, today the western region of Slovakia where they continued to produce faience. After the Anabaptist community disintegrated in the last quarter of the 17th century, the production of faience was taken over by individual craftsmen.
The Moravian Museum in Brno holds one of the most representative collections of Anabaptist faience in the Czech Republic. Its origin dates back to the early years after the foundation of the Francis Museum, the predecessor of today’s Moravian Museum. At present, it comprises around 250 items.
Every Text is a Performance: A Pre-History of Performance Philosophy
Authors: Kornhaber David 
Published: April 2016

This article traces a genealogy of performance philosophy along two separate lines within the history of the twentieth-century academy. On the one hand, it locates within the long history of philosophically-informed studies of dramatic literature a partial model for the work of performance philosophy, one that applied philosophical scrutiny to dramatic texts without ever extending the same consideration to theatrical performance—in spite of the practical theatrical work of many of this movement’s leading academic proponents. On the other hand, it identifies in the poststructualist rethinking of textual authority an opening for the reconsideration of philosophical communication that returns performance to a place of philosophical potential that it has not securely held since before Plato’s dialogues. It is argued that the intersection of these two trend lines in academic thought should be regarded as constituting an important intellectual genesis point for the emergence of performance philosophy and a useful means of approaching the purposes and boundary points of the field.
Principes de traitement des psychoses
Authors: Delhommeau Laurent 
Published: April 2016

Ce texte propose de passer en revue les grands principes du traitement des psychoses, principes élaborés dans le lien le plus étroit aux avancées de la théorie psychanalytique : modalités de l’accueil, réception du délire et des hallucinations, usage des concepts d’historial, de forclusion, de fonctions parentales. Plusieurs exemples cliniques sont apportés, témoignant de l’application de ces principes.
Me donner l’envie d’agir avec courage...
Authors: Derobert Yann 
Published: April 2016

Au milieu des années 1980, le psychiatre Marius Romme et la journaliste Sandra Escher s’engagent, avec une visée libératrice, dans une coopération avec des personnes qui entendent des voix et dont la plupart ont reçu un diagnostic de schizophrénie. Fondant leur approche sur la contribution attendue de chacun(e), leur initiative a inspiré un vaste mouvement international qui interroge les pratiques traditionnelles – désarmantes – de la psychiatrie et constitue un appel à dépasser nos peurs et nos préjugés.
Stability of Keratometric Astigmatism After Non-penetrating Femtosecond Laser Intrastromal Astigmatic Keratotomy Performed During Laser Cataract Surgery
Authors: Day Alexander C. , Stevens Julian D. 
Published: April 2016

PURPOSE:
To investigate the stability of keratometric astigmatism after femtosecond laser intrastromal astigmatic keratotomy (ISAK) performed during laser cataract surgery.

METHODS:
In this prospective comparative case series, data were collected from patients during follow-up 1 and 6 months after laser-assisted cataract surgery. Corneal keratometry was measured preoperatively and postoperatively by Topcon KR8100PA topographer-autorefractor (Topcon Corporation, Tokyo, Japan). Astigmatic analyses were performed by Alpins' method to calculate surgically induced astigmatism (SIA). All operations were performed by a single surgeon.

RESULTS:

Data were available on 263 eyes, of which 87 had undergone ISAK during cataract surgery for astigmatism management (cases) and 176 had cataract surgery without ISAK (controls). For ISAK cases, comparing the magnitudes of the individual SIA vectors at 1 and 6 months postoperatively showed a 0.09 diopters cylinder (DC) regression (
P
= .009). Calculating the change in SIA between 1 and 6 months considering both magnitude and angular direction, the mean regression vector was 0.08 DC @ 94°. For controls (without ISAK), comparing the magnitudes of the individual SIA vectors at 1 and 6 months postoperatively showed a 0.11 DC regression (
P
< .001). Calculating the change in SIA between 1 and 6 months considering magnitude and angular direction, the mean vector was 0.14 DC @ 88°. There was no significant difference in SIA regression magnitudes between cases and controls.

CONCLUSIONS:
For both cases with and without ISAK, there were small but statistically significant regressions in SIA between 1 and 6 months postoperatively. These values were low and appear to be of little clinical significance.

[
J Refract Surg
. 2016;32(3):152–155.]
Influence of Near-Segment Positioning in a Rotationally Asymmetric Multifocal Intraocular Lens
Authors: Song In Seok , Yoon Sam Young , Kim Jae Yong , Kim Myoung Joon , Tchah Hungwon 
Published: April 2016

PURPOSE:
To compare visual performance and higher order aberrations (HOAs) based on the position of the near segment in eyes with rotationally asymmetric multifocal intraocular lenses (IOLs).

METHODS:
Asymmetric multifocal IOLs (Lentis Mplus LS-313; Oculentis Optikgeräte GmbH, Wetzlar, Germany) were implanted with the near segment positioned either inferiorly, superiorly, or temporally. Uncorrected distance (UDVA), intermediate (UIVA), and near (UNVA) visual acuity, corrected distance visual acuity (CDVA), and distance-corrected intermediate (DCIVA) and near (DCNVA) visual acuity, contrast sensitivity, HOAs, and subjective symptom questionnaires were compared at 1 month postoperatively.

RESULTS:

Forty-five eyes from 45 patients were evaluated (n = 25, 9, and 11 eyes in the inferior, superior, and temporal groups, respectively). No significant differences in UDVA, UIVA, UNVA, CDVA, DCIVA, or DCNVA were found between the three groups (
P
> .05). The temporal group showed the best results in UDVA, CDVA, and DCNVA, but the inferior group showed the best results in DCIVA and UNVA and the superior group showed the best results in UIVA. Contrast sensitivity and the subjective symptom questionnaire also did not demonstrate any significant differences (
P
> .05). Total HOA and spherical aberration did not demonstrate any statistically significant differences (
P
> .05), but vertical coma and horizontal coma demonstrated significant differences based on near segment position (
P
< .001).

CONCLUSIONS:
The position of the near segment in eyes with rotationally asymmetric multifocal IOLs demonstrates no significant effect on visual performance.

[
J Refract Surg.
2016;32(4):238–243.]
Unusual Presentation of Hydatid Cyst in Cervical Region
Authors: Singh Surjit , Singh Digvijay , Banjara Hansa , Sarkar Sutanu , Mungutwar Varsha 
Published: April 2016

ABSTRACT
Cervical involvement of the hydatid disease is rare entity occurring in less than 0.5% of patients. Hydatid disease is prevalent in Asia, Australia, and Eastern and Southern Europe. Hydatid disease caused by Echinococcus granulosus is often manifested by a slow-growing cystic mass. Hydatid cysts may be found in almost every part of the body; however, the lungs and liver are the most involved locations. This study reports an unusual presentation of the hydatid cyst over cervical region of neck.

How to cite this article
Singh D, Banjara H, Mungutwar V, Sarkar S, Singh S. Unusual Presentation of Hydatid Cyst in Cervical Region. Int J Head Neck Surg 2015;6(3):112-114.
Intact Cornual Ectopic Pregnancy and Dermoid Cyst With Intraoperative Rupture
Authors: Martingano Daniel , Martingano Francis X. 
Published: April 2016

AbstractOf ectopic pregnancies encountered in clinical practice, more than 95% are located within the fallopian tube, and 2% to 4% are cornual. A cornual ectopic pregnancy is a serious clinical condition and poses diagnostic and therapeutic challenges. Thus, understanding the clinical course and treatment options is essential. The authors describe the case of a 29-year-old woman who presented to the Department of Obstetrics and Gynecology. The patient was suspected of having a cornual pregnancy, and a dermoid cyst had been detected during routine ultrasonography. In the absence of maternal symptoms, the clinical scenario is potentially dangerous and must be treated promptly and efficiently to decrease morbidity and mortality.
Low-ohmic-contact-resistance V-based electrode for n-type AlGaN with high AlN molar fraction
Authors: Mori Kazuki , Takeda Kunihiro , Kusafuka Toshiki , Iwaya Motoaki , Takeuchi Tetsuya , Kamiyama Satoshi , Akasaki Isamu , Amano Hiroshi 
Published: April 2016

Abstract
We investigated a V-based electrode for the realization of low ohmic-contact resistivity in n-type AlGaN with a high AlN molar fraction characterized by the circular transmission line model. The contact resistivity of n-type Al0.62Ga0.38N prepared using the V/Al/Ni/Au electrode reached 1.13 × 10−6 Ω cm2. Using this electrode, we also demonstrated the fabrication of UV light-emitting diodes (LEDs) with an emission wavelength of approximately 300 nm. An operating voltage of LED prepared using a V/Al/Ni/Au electrode was 1.6 V lower at 100 mA current injection than that prepared using a Ti/Al/Ti/Au electrode, with a specific contact resistance of approximately 2.36 × 10−4 Ω cm2 for n-type Al0.62Ga0.38N.
The damage is done: Low fault friction recorded in the damage zone of the shallow Japan Trench décollement
Authors: Keren Tucker T. , Kirkpatrick James D. 
Published: April 2016

AbstractFault damage zones record the integrated deformation caused by repeated slip on faults and reflect the conditions that control slip behavior. To investigate the Japan Trench décollement, we characterized the damage zone close to the fault from drill core recovered during Integrated Ocean Drilling Program Expedition 343 (Japan Trench Fast Drilling Project (JFAST)). Core‐scale and microscale structures include phyllosilicate bands, shear fractures, and joints. They are most abundant near the décollement and decrease in density sharply above and below the fault. Power law fits describing the change in structure density with distance from the fault result in decay exponents (n) of 1.57 in the footwall and 0.73 in the hanging wall. Microstructure decay exponents are 1.09 in the footwall and 0.50 in the hanging wall. Observed damage zone thickness is on the order of a few tens of meters. Core‐scale structures dip between ~10° and ~70° and are mutually crosscutting. Compared to similar offset faults, the décollement has large decay exponents and a relatively narrow damage zone. Motivated by independent constraints demonstrating that the plate boundary is weak, we tested if the observed damage zone characteristics could be consistent with low‐friction fault. Quasi‐static models of off‐fault stresses and deformation due to slip on a wavy, frictional fault under conditions similar to the JFAST site predict that low‐friction fault produces narrow damage zones with no preferred orientations of structures. These results are consistent with long‐term frictional weakness on the décollement at the JFAST site.