bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: REACTIONS OF TITANIUM AND ZIRKONIUM ALKOXIDES WITH SALICYLALDEHYDE
Authors: MEHROTRA R. C. , GUPTA V. D. , BHARARA P. C. 
Published: March 2016

AbstractTi‐ und Zr‐alkoxide bilden mit Salicylaldehyd in kaltem Zustand die Salicylaldehydatoalkoxy‐Verbindungen (I) quantitativ, die sich in siedendem Benzol einer Meerwein‐Ponndorf‐Reduktion unterwerfen und abhängig vom Alkoxid die Salicylalkoholato‐Verbindungen (IIa) bzw. die Produkte (III) mit gemischten Liganden liefern.
ChemInform Abstract: UNTERSUCHUNG DES DIHYDRATISIERTEN CHROM(II)‐SUCCINATS
Authors: SHARROCK PATRICK , THEOPHANIDES THEOPHILE , BRISSE FRANCOIS 
Published: March 2016

AbstractNach Reduktion von Cr‐trichlorid‐hexahydrat mit Zn in HCl wurde durch Reak tion mit wasserfreiem Na‐succinat die Titelverbindung (I) erstmalig dargestellt und durch IR‐Daten charakterisiert.
ChemInform Abstract: SYNTHESE VON CHROM(III)‐TRIS‐(DIMETHYLPHOSPHONIUM‐BIS‐METHYLID)
Authors: KURRAS ERHARD , ROSENTHAL UWE , MENNENGA HERBERT , OEHME GUENTHER 
Published: March 2016

AbstractDie Reaktion des Chromats (I) mit dem Phosphoniumsalz (ID unter anaeroben . Bedingungen liefert die oxidations‐ und hydrolyseempfindliche Titelverbindung (III), die auch durch Umsetzung von Trichloro‐tris‐[tetrahydrofuran]‐chrom mit Trimethylmethylenphosphoran, metalliert mit Methyl‐ oder Phenyllithium, dargestellt werden kann.
ChemInform Abstract: PRIMARY PHOTOCHEMISTRY OF MATRIX ISOLATED TRICARBONYLCYCLOBUTADIENEIRON
Authors: CHAPMAN O. L. , PACANSKY J. , WOJTKOWSKI P. W. 
Published: March 2016

AbstractDie Belichtung von (I) in Krypton führt unter Abspaltung von Kohlenmonoxid zu Dicarbonylcyclobutadieneisen (II).
ChemInform Abstract: OXIDISING BEHAVIOUR OF MOLYBDENUM AND TUNGSTEN HEXAFLUORIDES
Authors: PRESCOTT A. , SHARP D. W. A. , WINFIELD J. M. 
Published: March 2016

AbstractMolybdän‐ und Wolfram‐hexafluorid (I) bzw. (IV) reagieren mit Acetonitril (II) bei Raumtemperatur zu den Komplexen (III) bzw. (V).
ChemInform Abstract: ENDO‐ATTACK ON CO‐ORDINATED NORBORNADIENE, CRYSTAL STRUCTURE OF DI‐MU‐CHLORO‐BIS(ENDO‐3‐PHENYLNORBORNEN‐2‐YL‐ENDO‐PALLADIUM)
Authors: SEGNITZ A. , BAILEY P. M. , MAITLIS P. M. 
Published: March 2016

AbstractDer Platin‐Komplex (I) bildet mit 0,5 Äquivalent Diphenylquecksilber (II) das Monophenylderivat (III) und mit 2 Äquivalenten Diphenylquecksilber (II) das Diphenylderivat (IV).
ChemInform Abstract: DIE SYNTHESE VON THIAZOLDERIVATEN 25. MITT. EINEN BENZOTHIAZOLKERN ENTHALTENDE MALACHITGRUENANALOGA
Authors: ZUBAROVSKII V. M. , KHODOT G. P. 
Published: March 2016

AbstractDurch Kondensation der Benzothiazolaldehyde (I), (V) und (VIII) mit Dimethylanilin (II) in Gegenwart von 30%iger Salzsäure bei 150°C werden die Leukobasen (III), (VI) und (IX) erhalten und mit Bleidioxid in Salzsäure zu Triphenylmethan analogen Farbstoffen (IV), (VII) und (X) oxidiert.
ChemInform Abstract: THE SYNTHESIS OF MISEROTOXIN AND STRUCTURAL ANALOGS
Authors: BAER HANS H. , LEE CHIU SHUET‐HING , SHIELDS DOUGLAS C. 
Published: March 2016

AbstractDie Kondensation von α‐D‐Acetobromglucose (I) mit den Nitroalkoholen (II) in Gegenwart von Ag‐Salzen führt zu den β‐D‐Glucopyranosidtetraacetaten (III).
ChemInform Abstract: SYNTHESIS AND BIOLOGICAL STUDIES OF NOVEL BRADYKININ ANALOGUES
Authors: FELIX A. M. , JIMENEZ M. H. , VERGONA R. , COHEN M. R. 
Published: March 2016

AbstractNach der Merrifield‐Methode werden" neue Nonapeptid‐ und Decapeptidanaloga (II) des Bradykinins (I) hergestellt, wobei die Carbonsäuren (III)‐(VII) ′ über ihre BOC‐Derivate an die Stelle des Prolins in Stellung 3 eingeschoben werden.
ChemInform Abstract: SEMISYNTHETIC PENICILLINS WITH SUBSTITUTED NEOPENTYL SIDE‐CHAINS
Authors: ZOSIM L. A. , SZTARICSKAI F. , BOGNAR R. 
Published: March 2016

AbstractAus den Carbonsäuren (I) werden mit Thionylchlorid bzw. mit dem Dichlor‐ äther (III) (häufigeres Verfahren) die entsprechenden Säurechloride dargestellt, die unmittelbar zur Acylierung von 6‐Aminopenicillansäure eingesetzt werden; es werden so die halbsynthetischen Penicilline (II) [isoliert als Na‐, K‐, Morpholin‐, Novocain‐ bzw. Dibenzyläthylendiamin‐Salze] gewonnen.
ChemInform Abstract: SYNTHETIC PENICILLINS, HETEROCYCLIC ANALOGS OF AMPICILLIN, STRUCTURE ACTIVITY RELATIONSHIPS
Authors: HATANAKA M. , ISHIMARU T. 
Published: March 2016

AbstractAus den Acetyl‐thiophenen (I) entstehen mit Selendioxid die Ketosäuren (IIa), deren Oxime (IIb) mit Na‐Hg zu den Aminen (III) reduziert werden können.
ChemInform Abstract: ABSOLUTE CONFIGURATIONS OF (‐)‐14‐METHYL‐CIS‐8‐HEXADECEN‐1‐OL AND METHYL (‐)‐14‐METHYL‐CIS‐8‐HEXADECENOATE, THE SEX ATTRACTANT OF FEMALE DERMESTID BEETLE, TROGODERMA INCLUSUM LE CONTE
Authors: MORI K. 
Published: March 2016

AbstractDie Strukturen der beiden Hexadecene (I) und (II) werden über Synthesen sichergestellt.
Comparison of PCSK9 Inhibitor Evolocumab vs Ezetimibe in Statin‐Intolerant Patients: Design of the Goal Achievement After Utilizing an Anti‐PCSK9 Antibody in Statin‐Intolerant Subjects 3 (GAUSS‐3) Trial
Authors: Nissen Steven E. , Dent‐Acosta Ricardo E. , Rosenson Robert S. , Stroes Erik , Sattar Naveed , Preiss David , Mancini G.B. John , Ballantyne Christie M. , Catapano Alberico , Gouni‐Berthold Ioanna , Stein Evan A. , Xue Allen , Wasserman Scott M. , Scott Rob , Thompson Paul D. ,   on behalf of the GAUSS‐3 Investigators
Published: March 2016

AbstractStatins are the accepted standard for lowering low‐density lipoprotein cholesterol (LDL‐C). However, 5% to 10% of statin‐treated patients report intolerance, mostly due to muscle‐related adverse effects. Challenges exist to objective identification of statin‐intolerant patients. Evolocumab is a monoclonal antibody that binds proprotein convertase subtilisin/kexin type 9 (PCSK9), resulting in marked LDL‐C reduction. We report the design of Goal Achievement After Utilizing an Anti‐PCSK9 Antibody in Statin‐Intolerant Subjects 3 (GAUSS‐3), a phase 3, multicenter, randomized, double‐blind, ezetimibe‐controlled study to compare effectiveness of 24 weeks of evolocumab 420 mg monthly vs ezetimibe 10 mg daily in hypercholesterolemic patients unable to tolerate an effective statin dose. The study incorporates a novel atorvastatin‐controlled, double‐blind, crossover phase to objectively identify statin intolerance. Eligible patients had LDL‐C above the National Cholesterol Education Project Adult Treatment Panel III target level for the appropriate coronary heart disease risk category and were unable to tolerate ≥3 statins or 2 statins (one of which was atorvastatin ≤10 mg/d) or had a history of marked creatine kinase elevation accompanied by muscle symptoms while on 1 statin. This trial has 2 co‐primary endpoints: mean percent change from baseline in LDL‐C at weeks 22 and 24 and percent change from baseline in LDL‐C at week 24. Key secondary efficacy endpoints include change from baseline in LDL‐C, percent of patients attaining LDL‐C <70 mg/dL (1.81 mmol/L), and percent change from baseline in total cholesterol, non–high‐density lipoprotein cholesterol, and apolipoprotein B. Recruitment of 511 patients was completed on November 28, 2014.
Carboxymethylsulfonylated Ribopyrimidines: Rational Design of Ribonuclease A Inhibitors Employing Chemical Logic
Authors: Datta Dhrubajyoti , Dasgupta Swagata , Pathak Tanmaya 
Published: March 2016

AbstractHydrolysis of RNA by ribonuclease A crucially depends on the participation of the 2′‐OH group as well as the positioning of the internucleotide bond at two different sites of the enzyme. Therefore, ribopyrimidines were modified with −SO2CH2CO2H, an acidic functional group, which was expected to interact with the phosphate binding site. These ribonucleosides were designed to understand the influence of the 2′‐OH group of these inhibitors on ribonuclease A inhibition along with the effect of the −SO2CH2CO2H group. The “down” configuration of the 2′‐OH group enhanced the inhibitory properties (Ki=1.75 μm) and also imparted important Val43 H‐bonding with the furanose oxygen atom of the inhibitors. One of the most important aspects of this work is that there was no serendipitous discovery of the inhibitors. The inhibitors reported in this manuscript were obtained by design by employing chemical logic.
Study on the relationship between network position and organizational performance based on meta‐analysis
Authors: Xie Min , Zhao Hongyan , Zhu Nana , Liu Chengju , Jiang Tianying 
Published: March 2016

SummaryThe relationship between network position and organizational innovation has been a focus of organizational innovation theory research. However, there is no consensus whether network position can promote organizational innovation. This study meta‐analytically integrated results from piles of network position researches in organizational innovation in 20 years. Based on 81 independent samples (N = 16975), it found a positive significance between network position and organizational innovation with r = 0.448. Then, it explored this relationship from the perspective of time factor, cultural differences, organizational scales, measuring dimension, and the existence of mediators. It turned out that there were significant differences in the relationship under time factor, organizational size, measuring dimension, and the existence of mediators. However, there was no significant difference in the relationship under difference culture. Copyright © 2016 John Wiley & Sons, Ltd.
Evaluation of in‐memory storage engine for machine learning analysis of security events
Authors: Sapegin Andrey , Gawron Marian , Jaeger David , Cheng Feng , Meinel Christoph 
Published: March 2016

SummaryModern security information and event management systems should be capable to store and process high amount of events or log messages in different formats and from different sources. This requirement often prevents such systems from usage of computational heavy algorithms for security analysis. To deal with this issue, we built our system based on an in‐memory database with an integrated machine learning library, namely, SAP HANA. Three approaches, that is, (1) deep normalisation of log messages, (2) storing data in the main memory and (3) running data analysis directly in the database, allow us to increase processing speed in such a way that machine learning analysis of security events becomes possible nearly in real time. Besides that, we developed a universal anomaly detection algorithm, which uses vector space model to represent and cluster textual log messages. Together with deep normalisation approach, this algorithm solves the problem of correlation for heterogenous security events containing many text fields. To prove our concepts, we measured the processing speed for the developed system on the data generated using Active Directory testbed, compared it with classical system architecture based on PostgreSQL database and showed the efficiency of our approach for high‐speed analysis of security events. Copyright © 2016 John Wiley & Sons, Ltd.
Metal–Oxygen Bond Ionicity as an Efficient Descriptor for Doped NiOOH Photocatalytic Activity
Authors: Zaffran Jeremie , Toroker Maytal Caspary 
Published: March 2016

AbstractThe computational design of solid catalysts has become a very “hot” field during the last decades, especially with the recent increase in computational tool performance. However, theoretical techniques are still very time demanding because they require the consideration of many adsorption configurations of the reaction intermediates on the surface. Herein, we propose to use the metal–oxygen (M−O) bond ionicity as a descriptor for the photocatalytic activity of one of the best catalysts for the oxygen evolution reaction (OER). Ionicity is a bulk property and thus carries the advantage of being easily obtainable from a simple Bader charge analysis by using density functional theory (DFT). We will show that this criterion can be used successfully to design efficient dopants for NiOOH material. This catalyst is known to exhibit interesting photoelectrochemical properties for OER if it is doped with specific transition metals. Finally, we demonstrate that other electronic properties that relate to bulk calculation, such as oxidation states and density of states, are not alone sufficient to explain the photocatalytic activity of the material. Thus, M−O bond ionicity attracts significant interest compared with other bulk observables obtained by using DFT computations.
Harnessing Reversible Electronic Energy Transfer: From Molecular Dyads to Molecular Machines
Authors: Denisov Sergey A. , Yu Shinlin , Pozzo Jean‐Luc , Jonusauskas Gediminas , McClenaghan Nathan D. 
Published: March 2016

AbstractReversible electronic energy transfer (REET) may be instilled in bi‐/multichromophoric molecule‐based systems, following photoexcitation, upon judicious structural integration of matched chromophores. This leads to a new set of photophysical properties for the ensemble, which can be fully characterized by steady‐state and time‐resolved spectroscopic methods. Herein, we take a comprehensive look at progress in the development of this type of supermolecule in the last five years, which has seen systems evolve from covalently tethered dyads to synthetic molecular machines, exemplified by two different pseudorotaxanes. Indeed, REET holds promise in the control of movement in molecular machines, their assembly/disassembly, as well as in charge separation.
A Deep‐Blue Electroluminescent Device Based on a Coumarin Derivative
Authors: Kumar Shiv , Puttaraju Boregowda , Patil Satish 
Published: March 2016

AbstractThe design and synthesis is reported of 7‐(9H‐carbazol‐9‐yl)‐4‐methylcoumarin (Cz–Cm), comprising a carbazole donor moiety and a 4‐methylcoumarin acceptor unit, for use in a blue organic light‐emitting diode. A detailed solid state, theoretical and spectroscopic study was performed to understand the structure–property relationships. The material exhibits deep‐blue emission and high photoluminescence quantum yield both in solution and in a doped matrix. A deep‐blue electroluminescence emission at 430 nm, a maximum brightness of 292 cd m−2 and an external quantum efficiency of 0.4 % was achieved with a device configured as follows: ITO/NPD (30 nm)/TCTA (20 nm)/CzSi(10 nm)/10 wt % Cz–Cm:DPEPO (10 nm)/TPBI (30 nm)/LiF (1 nm)/Al [ITO=indium tin oxide, NPD=N,N′‐di(1‐naphthyl)‐N,N′‐diphenyl‐(1,1′‐biphenyl)‐4,4′‐diamine, TCTA=tris(4‐carbazoyl‐9‐ylphenyl)amine, CzSi=9‐(4‐tert‐butylphenyl)‐3,6‐bis(triphenylsilyl)‐9H‐carbazole, DPEPO=bis[2‐(diphenylphosphino)phenyl]ether oxide, TPBI=1,3,5‐tris(N‐phenylbenzimidazol‐2‐yl)benzene].
Membrane traffic during axon development
Authors: Wojnacki José , Galli Thierry 
Published: March 2016

ABSTRACTBrain formation requires the establishment of complex neural circuits between a diverse array of neuronal subtypes in an intricate and ever changing microenvironment and yet with a large degree of specificity and reproducibility. In the last three decades, mounting evidence has established that neuronal development relies on the coordinated regulation of gene expression, cytoskeletal dynamics, and membrane trafficking. Membrane trafficking has been considered important in that it brings new membrane and proteins to the plasma membrane of developing neurons and because it also generates and maintains the polarized distribution of proteins into neuronal subdomains. More recently, accumulating evidence suggests that membrane trafficking may have an even more active role during development by regulating the distribution and degree of activation of a wide variety of proteins located in plasma membrane subdomains and endosomes. In this article the evidence supporting the different roles of membrane trafficking during axonal development, particularly focusing on the role of SNAREs and Rabs was reviewed. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1185–1200, 2016
Ruthenium Complexes Containing 2,2′‐Bipyridine and 1,3,5‐Triaza‐7‐phosphaadamantane
Authors: Scalambra Franco , Serrano‐Ruiz Manuel , Nahim‐Granados Samira , Romerosa Antonio 
Published: March 2016

AbstractWater‐soluble complexes cis‐[Ru(bpy)2(PTA)2]Cl2 (1Cl2), cis‐[Ru(bpy)2(PTA)2](PF6)2 [1(PF6)2], trans‐[Ru(bpy)2(PTA)2](CF3SO3)2 [2(CF3SO3)2], cis‐[Ru(bpy)2(PTA)(H2O)](CF3SO3)2 [3(CF3SO3)2], cis‐[Ru(bpy)2(PTAH)(H2O)](CF3SO3)3·2CF3SO3H [4(CF3SO3)3·2CF3SO3H], cis‐[Ru(bpy)2(PTAH)2](CF3SO3)4·4CF3SO3H [5(CF3SO3)4·4CF3SO3H], and trans‐[Ru(bpy)2(PTAH)2](CF3SO3)4·4CF3SO3H [6(CF3SO3)4·4CF3SO3H] (bpy = 2,2′‐bipyridyl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane) have been synthesized and characterized by elemental analysis, NMR, and IR spectroscopy. The crystal structures of 1(PF6)2, 2(CF3SO3)2, and 3(CF3SO3)2 were obtained by single‐crystal X‐ray diffraction. Both experimental and computational techniques were utilized to perform a detailed analysis of the structural and electronic properties of complexes 1 and 2 in water in both the deprotonated and protonated state and under N2 and air. Luminescence studies showed that these complexes are active fluorescence compounds, despite the presence of monophosphines in their structure. The pH sensitivity of the emission band of both complexes and their photohydrolysis in acidic water solution was studied. Both complexes release a PTA molecule under selective irradiation in acidic water to give complex 4. Cyclic voltammetry showed that, in water, irreversible anodic oxidation corresponding to the RuII/RuIII redox process occurs for 1, whereas for 2 the process is quasi‐reversible, while in N,N‐dimethylformamide for both complexes they are irreversible and occur at lower potential than in water.
Straightforward High‐Pressure Synthesis and Characterization of Indium‐Based Thiospinels: Photocatalytic Potential for Hydrogen Production
Authors: Falcón Horacio , Tartaj Pedro , Vaquero Fernando , Navarro Rufino M. , Fierro Jose Luis G. , Bolletta Juan P. , de Paoli Juan M. , Carbonio Raul E. , Fernández‐Díaz Maria Teresa , Alonso Jose Antonio 
Published: March 2016

AbstractTernary chalcogenides (AB2X4) based on the spinel structure are gaining a great deal of attention because of the possibility of tuning their magnetic and optoelectronic properties not only by changing chemical composition but also by altering their degree of inversion. Here we report a rapid high‐pressure synthetic method for the synthesis of MIn2S4 powders starting from commercially available solid sulfides. We prove the versatility of our method by reporting the synthesis of six members of the MIn2S4 family (M = Mn, Fe, Co, Ni, Zn, and Cd) under high‐pressure conditions (3.5 GPa); these compounds show complete to moderate degrees of inversion. Furthermore, this family covers a spectral region that includes visible band gaps. Interestingly, the structural refinement carried out by X‐ray and neutron diffraction allows one to establish positive correlations between the gap and different parameters, including the degree of inversion. Finally, as a proof‐of‐concept, these ternary chalcogenides show moderate photocatalytic hydrogen production from aqueous solutions.
Structural Diversity of Tris(2‐hydroxy­aryl)methane‐Derived Aluminium Complexes
Authors: Oishi Masataka , Ichinose Yuri , Nomura Nobuyoshi 
Published: March 2016

AbstractTris(2‐hydroxyaryl)methane ligands coordinate to main group and transition metals in a variety of modes. However, for aluminium, only trinuclear complexes have previously been reported. To investigate the possibility of also developing both mono‐ and dinuclear aluminium complexes, the reactions of Et3Al and tris(2‐hydroxyaryl)methanes have been examined under various conditions. In this work, trialuminium complex 1b was formed by disproportionation of the initially generated monomeric complex 2′ (Al/ligand = 1:1) with Et3Al. This reaction allowed us to selectively synthesize aluminium complexes 1b, 2, 5, and 7 with different coordination modes. Furthermore, mononuclear complex 5b underwent rearrangement to yield the tris(aryloxy) complex 8 in C6D6 under the appropriate conditions.
CdP2N4 and MnP2N4 – Ternary Transition‐Metal Nitridophosphates
Authors: Pucher Florian J. , Karau Friedrich W. , Schmedt auf der Günne Jörn , Schnick Wolfgang 
Published: March 2016

AbstractThe ternary transition‐metal nitridophosphates CdP2N4 and MnP2N4 have been synthesized under high‐pressure high‐temperature conditions (5–8 GPa, 1000–1300 °C) by using the multianvil technique. Cd and Mn azides can be used as the starting materials, however, with respect to safety considerations, it is much more advantageous to start from metal powders and phosphorus nitride imide, HPN2. Both nitridophosphates crystallize in a structure closely related to the megacalsilite structure type. As a result of the known issues concerning superstructures with this type of structure, TEM investigations were performed on CdP2N4, which revealed that the megacalsilite superstructure is not equally pronounced in all crystallites. By adding NH4Cl as mineralizer, single crystals were obtained that exhibit unequally pronounced superstructure reflections. Consequently, an averaged structural model was used and refined by the Rietveld method [P6322, a = 16.7197(3), c = 7.6428(2) Å, V = 1850.3(2) Å3, Rp = 0.0671, wRp = 0.0869 for CdP2N4 and P6322, a = 16.5543(2), c = 7.5058(2) Å, V = 1781.3(1) Å3, Rp = 0.0526, wRp = 0.0697 for MnP2N4]. The 31P NMR spectra exhibit four signal groups at (6.4, 4.8), 0.8, and –9.7 ppm with pronounced shoulders belonging to the same phase in an approximate area ratio of 4.8:1.1:2.0, thereby proving at least eight P sites.
Hyperfine Interactions and Metal Atom Dynamics in a Number of Stannyl Phosphide Compounds and the Detailed Crystal Structure of Triphenyltin Chloride Revisited
Authors: Bogoslavsky Benny , Nowik Israel , Herber Rolfe H. 
Published: March 2016

AbstractTemperature‐dependent 119Sn Mössbauer effect (ME) spectroscopy has been used to elucidate the hyperfine parameters (isomer shift and quadrupole splitting) as well as the dynamics of the motion of tin in three triphenyltin phosphide complexes, namely P(SnPh3)3 (C54H45PSn3, 1), P7(SnPh3)3 (C54H45P7Sn3, 2), and [Na(benzo‐15‐crown‐5)][P(SnPh3)2] (C50H50NaO5PSn2, 3), as well as in triphenyltin chloride (4). Although the isomer shifts are very similar for all four compounds, the quadrupole splitting is dependent upon their detailed structures. The metal atom vibrations are essentially isotropic with respect to the principal symmetry axis passing through the tin atom and the triphenyltin moiety. The crystal structure of triphenyltin chloride has been re‐determined at four different temperatures, and the root‐mean‐square amplitudes‐of‐vibration of the metal atom have been evaluated from the crystallographic Ui,j values and compared with the corresponding data derived from the Mössbauer measurements. These metal atom dynamics have been compared with those of the stannyl phosphide complexes derived from ME data and related to their structural details. The sensitivity of the ME technique with respect to elucidating the metal atom dynamics is demonstrated in detail.
Electrochemical Biosensor Utilizing Supramolecular Association of Enzyme on Sol−gel Matrix Embedded Gold Nanoparticles Supported Reduced Graphene Oxide−cyclodextrin Nanocomposite
Authors: Manivannan Shanmugam , Kim Kyuwon 
Published: March 2016

AbstractHerein we present β‐cyclodextrin (CD)‐functionalized reduced graphene oxide (RGO) nanosheets supported on silicate sol‐gel matrix‐embedded gold nanoparticles (Au NPs) modified electrode as a new affinity binding nanocomposite. The modified electrode is fabricated through layer‐by‐layer drop casting followed by immobilization of chemically modified enzyme conjugate (horse radish peroxidase (HRP)−adamantane carboxylic acid (ADA)). This affinity system is based on the supramolecular association between CDs and HRP−ADA and is mimicking the biological avidin−biotin interactions. CDs‐functionalized RGO (RGO−CD) functions as a macrocyclic host to form stable supramolecular inclusion complexes with enzyme conjugate. Besides Au NPs improve the interfacial interaction with RGO−CD nanosheets, and thus exhibit synergistic electrocatalytic effect toward H2O2 reduction in the presence of 1 mM hydroquinone.