bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reviewer Acknowledgements for International Business Research, Vol. 9, No. 4
Authors: Duran Kevin 
Published: January 2017

International Business Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Reviewers for Volume 9, Number 4Ahmad Shukri YazidAmaresh DasAmran AwangAndroniki KavouraAnna Paola MicheliArash RiasiFrancesco ScaleraHanna TrojanowskaIwona Gorzeń-MitkaJyoti SharmaKaren GulliverManuela Rozalia GaborMarcelino José JorgeMihaela SimionescuMiriam JankalováMohsen Malekalketab KhiabaniMonica Maria CorosMuhammad Ishtiaq IshaqPhilippe Van CauwenbergeRadoslav JankalRaphael DornierRoxanne StevensSam OkoroafoSumathisri BhoopalanTamizhjyothi KailasamUmayal Kasi Kevin DuranOn behalf of,The Editorial Board of International Business ResearchCanadian Center of Science and Education
Reviewer Acknowledgements for International Business Research, Vol. 9, No. 7
Authors: Duran Kevin 
Published: January 2017

International Business Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Reviewers for Volume 9, Number 7 Giuseppe RussoKaren GulliverManlio Del GiudiceManuela Rozalia GaborMaria-Madela AbrudanMichaela Schaffhauser-LinzattiRosa LombardiRoxanne Helm StevensUmayal Kasi Kevin DuranOn behalf of,The Editorial Board of International Business ResearchCanadian Center of Science and Education
Mach–Zehnder wavelength selective switch embedded with microring resonators
Authors: Miura Kengo , Shoji Yuya , Mizumoto Tetsuya 
Published: January 2017

Abstract
A wavelength selective switch is proposed for optical wavelength division multiplexing network applications with very short range interconnections. The proposed device uses a Mach–Zehnder interferometer configuration incorporating wavelength selective phase shifters composed of microring resonators between their two arms. Wavelength selectivity is provided by cascaded microring resonators, which are placed in proximity so that the increase in excess loss caused by the difference in resonant wavelengths can be minimized. An on/off switching ratio >20 dB is obtainable when the drop/through transmittance ratio of the cascaded microring resonators is >22 dB and the coupling efficiency deviation from 50% is <1% in the directional couplers constructing the Mach–Zehnder interferometer.
Hepatic fibrosis and factors associated with liver stiffness in HIV mono-infected individuals
Authors: Sulyok Mihály , Ferenci Tamás , Makara Mihály , Horváth Gábor , Szlávik János , Rupnik Zsófia , Kormos Luca , Gerlei Zsuzsanna , Sulyok Zita , Vályi-Nagy István 
Published: January 2017

BackgroundLiver disease has become an important cause of morbidity and mortality even in those HIV-infected individuals who are devoid of hepatitis virus co-infection. The aim of this study was to evaluate the degree of hepatic fibrosis and the role of associated factors using liver stiffness measurement in HIV mono-infected patients without significant alcohol intake.MethodsWe performed a cross-sectional study of 101 HIV mono-infected patients recruited prospectively from March 1, 2014 to October 30, 2014 at the Center for HIV, St István and St László Hospital, Budapest, Hungary. To determine hepatic fibrosis, liver stiffness was measured with transient elastography. Demographic, immunologic and other clinical parameters were collected to establish a multivariate model. Bayesian Model Averaging (BMA) was performed to identify predictors of liver stiffness.ResultsLiver stiffness ranged from 3.0–34.3 kPa, with a median value of 5.1 kPa (IQR 1.7). BMA provided a very high support for age (Posterior Effect Probability-PEP: 84.5%), moderate for BMI (PEP: 49.3%), CD4/8 ratio (PEP: 44.2%) and lipodystrophy (PEP: 44.0%). For all remaining variables, the model rather provides evidence against their effect. These results overall suggest that age and BMI have a positive association with LS, while CD4/8 ratio and lipodystrophy are negatively associated.DiscussionOur findings shed light on the possible importance of ageing, overweight and HIV-induced immune dysregulation in the development of liver fibrosis in the HIV-infected population. Nonetheless, further controlled studies are warranted to clarify causal relations.
Upwelling and primary production during the U.S. GEOTRACES East Pacific Zonal Transect
Authors: Kadko David 
Published: January 2017

AbstractThe 2013 U.S. GEOTRACES Eastern Pacific Zonal Transect (EPZT) traversed the highly productive Peruvian coastal upwelling (PCU) region. In this work, the flux of nitrate into the euphotic zone is derived for stations within the PCU using a previously developed method whereby dilution of the water column 7Be inventory by upwelled 7Be‐free water provides a means to infer upwelling rates. Furthermore, with knowledge of upwelling rates, 7Be profiles are used to constrain vertical diffusivity within the upper thermocline. These transport terms are applied to nitrate profiles to estimate net community production between 79°W and 104°W along the EPZT, which includes the zone of active upwelling to the edge of the oligotrophic gyre. With a simple, one‐dimensional model, the calculated upwelling rates were inversely related to mixed layer temperature and ranged from 0 to 3.0 m/d. Results using a depth‐dependent upwelling rate with a component of horizontal advection are also described. Vertical diffusivities near the base of the euphotic zone were in the range 1.7–4.5 × 10−4 m2/s. These values are compared to those generated by analysis of temperature profiles. Net community production averaged 15 mmol C/m2/d for stations between 84°W and 104°W and was 134 mmol C/m2/d for the furthest inshore station at 79°W which displayed the lowest SST and greatest rate of upwelling.
Microtubule‐associated protein 1B: Novel paraneoplastic biomarker
Authors: Gadoth Avi , Kryzer Thomas J. , Fryer Jim , McKeon Andrew , Lennon Vanda A. , Pittock Sean J. 
Published: January 2017

ObjectiveTo report the identification of microtubule‐associated protein (MAP) 1B as the antigen of the previously described Purkinje cell cytoplasmic antibody type 2 (PCA‐2) antibody, its frequency, and clinical, oncological, and serological associations.MethodsArchival serum or cerebrospinal fluid (CSF) specimens were available from 96 of 118 consecutive PCA‐2‐IgG–seropositive patients identified during 1993–2016. The autoantigen, defined in mouse brain lysate by Western blot and mass spectrometry, was confirmed by dual immunohistochemical staining using commercial antibodies. The major antigenic region was defined by Western blot using recombinant protein fragments.ResultsIgG in 95 of 96 patients’ serum or CSF (but in none of 98 healthy or disease control subjects’ serum specimens) bound to recombinant MAP1B. A minority (17.5%) of patients’ IgG also bound to MAP1A. PCA‐2 was often accompanied by additional neural autoantibody markers of small‐cell carcinoma, including collapsin response‐mediated protein 5 (CRMP5) IgG (26%) or antineuronal nuclear antibody type 1 (ANNA‐1) IgG (also known as anti‐Hu; 13%). Neurological manifestations in 95 patients were (in decreasing frequency): peripheral neuropathy, 53%; cerebellar ataxia, dysmetria, or dysarthria, 38%; and encephalopathy, 27%. Cancer (majority small‐cell lung carcinoma [SCLC]) was detected in 66 of 84 evaluated patients (79%). The MAP1B (PCA‐2) autoantibody detection rate, among approximately 70,000 patients undergoing service neural autoantibody evaluation in 2015, was 0.024%, equaling amphiphysin IgG (0.026%) and more common than ANNA‐2 (also known as anti‐Ri; 0.016%) and PCA‐Tr (also known as delta/notch‐like epidermal growth factor‐related receptor [DNER]; 0.006%).InterpretationMAP1B, the PCA‐2 autoantigen, represents a novel target in paraneoplastic neurological disorders and has high predictive value for SCLC. Its relatively high prevalence, compared with other recognized paraneoplastic neural autoantibodies, justifies its testing in comprehensive paraneoplastic neural autoantibody evaluation. Ann Neurol 2017;81:266–277
Total Synthesis of (−)‐Tetrodotoxin and 11‐norTTX‐6(R)‐ol
Authors: Maehara Tomoaki , Motoyama Keisuke , Toma Tatsuya , Yokoshima Satoshi , Fukuyama Tohru 
Published: January 2017

AbstractThe enantioselective total synthesis of (−)‐tetrodotoxin [(−)‐TTX] and 4,9‐anhydrotetrodotoxin, which are selective blockers of voltage‐gated sodium channels, was accomplished from the commercially available p‐benzoquinone. This synthesis was based on efficient stereocontrol of the six contiguous stereogenic centers on the core cyclohexane ring through Ogasawara's method, [3,3]‐sigmatropic rearrangement of an allylic cyanate, and intramolecular 1,3‐dipolar cycloaddition of a nitrile oxide. Our synthetic route was applied to the synthesis of the tetrodotoxin congeners 11‐norTTX‐6(R)‐ol and 4,9‐anhydro‐11‐norTTX‐6(R)‐ol through late‐stage modification of the common intermediate. Neutral deprotection at the final step enabled easy purification of tetrodotoxin and 11‐norTTX‐6(R)‐ol without competing dehydration to their 4,9‐anhydro forms.
Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus
Authors: Comte Denis , Karampetsou Maria P. , Yoshida Nobuya , Kis‐Toth Katalin , Kyttaris Vasileios C. , Tsokos George C. 
Published: January 2017

ObjectiveEffector CD8+ T cell function is impaired in systemic lupus erythematosus (SLE) and is associated with a compromised ability to fight infections. Signaling lymphocytic activation molecule family member 7 (SLAMF7) engagement has been shown to enhance natural killer cell degranulation. This study was undertaken to characterize the expression and function of SLAMF7 on CD8+ T cell subsets isolated from the peripheral blood of SLE patients and healthy subjects.MethodsCD8+ T cell subset distribution, SLAMF7 expression, and expression of cytolytic enzymes (perforin, granzyme A [GzmA], and GzmB) on cells isolated from SLE patients and healthy controls were analyzed by flow cytometry. CD107a expression and interferon‐γ (IFNγ) production in response to viral antigenic stimulation in the presence or absence of an anti‐SLAMF7 antibody were assessed by flow cytometry. Antiviral cytotoxic activity in response to SLAMF7 engagement was determined using a flow cytometry–based assay.ResultsThe distribution of CD8+ T cell subsets was altered in the peripheral blood of SLE patients, with a decreased effector cell subpopulation. Memory CD8+ T cells from SLE patients displayed decreased amounts of SLAMF7, a surface receptor that characterizes effector CD8+ T cells. Ligation of SLAMF7 increased CD8+ T cell degranulation capacity and the percentage of IFNγ‐producing cells in response to antigen challenge in SLE patients and healthy controls. Moreover, SLAMF7 engagement promoted cytotoxic lysis of target cells in response to stimulation with viral antigens.ConclusionCD8+ T cell activation in response to viral antigens is defective in SLE patients. Activation of SLAMF7 through a specific monoclonal antibody restores CD8+ T cell antiviral effector function to normal levels and thus represents a potential therapeutic option in SLE.
Distributed Three‐Dimensional Formation Containment Control of Multiple Unmanned Aerial Vehicle Systems
Authors: Han Tao , Chi Ming , Guan Zhi‐Hong , Hu Bin , Xiao Jiang‐Wen , Huang Yuehua 
Published: January 2017

AbstractThis paper concentrates the distributed formation containment problems for multiple unmanned aerial vehicle (UAV) systems under both fixed directed and switching directed topologies. The objective is to introduce the formation control into the containment control research, where master UAVs should exchange information with each other to achieve and maintain a desired formation. Then, two different control protocols are proposed for the master UAVs and slave UAVs, respectively. Utilizing the algebraic graph theory and stability theory, some sufficient conditions are derived to guarantee the master UAVs complete a prespecified formation, while the states of the slave UAVs converge to a convex hull formed by those of the master UAVs. Finally, some numerical simulations are provided to verify the effectiveness of the theoretical results.
Validation of microRNA pathway polymorphisms in esophageal adenocarcinoma survival
Authors: Faluyi Olusola O. , Eng Lawson , Qiu Xin , Che Jiahua , Zhang Qihuang , Cheng Dangxiao , Ying Nanjiao , Tse Alvina , Kuang Qin , Dodbiba Lorin , Renouf Daniel J. , Marsh Sharon , Savas Sevtap , Mackay Helen J. , Knox Jennifer J. , Darling Gail E. , Wong Rebecca K. S. , Xu Wei , Azad Abul Kalam , Liu Geoffrey 
Published: January 2017

AbstractPolymorphisms in miRNA and miRNA pathway genes have been previously associated with cancer risk and outcome, but have not been studied in esophageal adenocarcinoma outcomes. Here, we evaluate candidate miRNA pathway polymorphisms in esophageal adenocarcinoma prognosis and attempt to validate them in an independent cohort of esophageal adenocarcinoma patients. Among 231 esophageal adenocarcinoma patients of all stages/treatment plans, 38 candidate genetic polymorphisms (17 biogenesis, 9 miRNA targets, 5 pri‐miRNA, 7 pre‐miRNA) were genotyped and analyzed. Cox proportional hazard models adjusted for sociodemographic and clinicopathological covariates helped assess the association of genetic polymorphisms with overall survival (OS) and progression‐free survival (PFS). Significantly associated polymorphisms were then evaluated in an independent cohort of 137 esophageal adenocarcinoma patients. Among the 231 discovery cohort patients, 86% were male, median diagnosis age was 64 years, 34% were metastatic at diagnosis, and median OS and PFS were 20 and 12 months, respectively. GEMIN3 rs197412 (aHR = 1.37, 95%CI: [1.04–1.80]; P = 0.02), hsa‐mir‐124‐1 rs531564 (aHR = 0.60, 95% CI: [0.53–0.90]; P = 0.05), and KIAA0423 rs1053667 (aHR = 0.51, 95% CI: [0.28–0.96]; P = 0.04) were found associated with OS. Furthermore, GEMIN3 rs197412 (aHR = 1.33, 95% CI: [1.03–1.74]; P = 0.03) and KRT81 rs3660 (aHR = 1.29, 95% CI: [1.01–1.64]; P = 0.04) were found associated with PFS. Although none of these polymorphisms were significant in the second cohort, hsa‐mir‐124‐1 rs531564 and KIAA0423 rs1053667 had trends in the same direction; when both cohorts were combined together, GEMIN3 rs197412, hsa‐mir‐124‐1 rs531564, and KIAA0423 rs1053667 remained significantly associated with OS. We demonstrate the association of multiple miRNA pathway polymorphisms with esophageal adenocarcinoma prognosis in a discovery cohort of patients, which did not validate in a separate cohort but had consistent associations in the pooled cohort. Larger studies are required to confirm/validate the prognostic value of these polymorphisms in esophageal adenocarcinoma.
In Situ XRD Study on Promotional Effect of Potassium on Carburization of Spray‐dried Precipitated Fe2O3 Catalysts
Authors: Niu Liwei , Liu Xingwu , Liu Xi , Lv Zhengang , Zhang Chenghua , Wen Xiaodong , Yang Yong , Li Yongwang , Xu Jian 
Published: January 2017

AbstractA study of the promotional effect of potassium on the carburization behavior of a series of spray‐dried precipitated Fe2O3 catalysts (100 Fe, 100 Fe/0.52 K, 100 Fe/1.54 K, and 100 Fe/2.4 K) has been performed by using in situ XRD. The average crystallite size evolution for species such as α‐Fe2O3, Fe3O4, χ‐Fe5C2, and θ‐Fe3C were followed. The potassium promoter clearly inhibits the reduction of α‐Fe2O3 to Fe3O4, where the decreasing binding energy in the Fe 2p3/2, O 1s and K 2p3/2 spectra from X‐ray photoelectron spectroscopy (XPS) suggests an electron density increase in Fe and O upon potassium promotion, leading to the enhanced covalency in the Fe−O bond. In terms of crystallite size during carburization, an optimum potassium loading exists in catalyst 100 Fe/0.52 K, which shows the fastest reduction to Fe3O4 with minimum crystallite sizes of around 7 to 15 nm. Potassium has no clear effect in determining the final crystallite size of χ‐Fe5C2. An arch‐shaped curve in the evolution of crystallite size of the Fe3O4 intermediate was observed, which can be explained by the activation energy difference between the bidirectional steps of the outward oxygen diffusion and the inward carbon diffusion.
Terminal Uranium(V/VI) Nitride Activation of Carbon Dioxide and Carbon Disulfide: Factors Governing Diverse and Well‐Defined Cleavage and Redox Reactions
Authors: Cleaves Peter A. , Kefalidis Christos E. , Gardner Benedict M. , Tuna Floriana , McInnes Eric J. L. , Lewis William , Maron Laurent , Liddle Stephen T. 
Published: January 2017

AbstractThe reactivity of terminal uranium(V/VI) nitrides with CE2 (E=O, S) is presented. Well‐defined C=E cleavage followed by zero‐, one‐, and two‐electron redox events is observed. The uranium(V) nitride [U(TrenTIPS)(N)][K(B15C5)2] (1, TrenTIPS=N(CH2CH2NSiiPr3)3; B15C5=benzo‐15‐crown‐5) reacts with CO2 to give [U(TrenTIPS)(O)(NCO)][K(B15C5)2] (3), whereas the uranium(VI) nitride [U(TrenTIPS)(N)] (2) reacts with CO2 to give isolable [U(TrenTIPS)(O)(NCO)] (4); complex 4 rapidly decomposes to known [U(TrenTIPS)(O)] (5) with concomitant formation of N2 and CO proposed, with the latter trapped as a vanadocene adduct. In contrast, 1 reacts with CS2 to give [U(TrenTIPS)(κ2‐CS3)][K(B15C5)2] (6), 2, and [K(B15C5)2][NCS] (7), whereas 2 reacts with CS2 to give [U(TrenTIPS)(NCS)] (8) and “S”, with the latter trapped as Ph3PS. Calculated reaction profiles reveal outer‐sphere reactivity for uranium(V) but inner‐sphere mechanisms for uranium(VI); despite the wide divergence of products the initial activation of CE2 follows mechanistically related pathways, providing insight into the factors of uranium oxidation state, chalcogen, and NCE groups that govern the subsequent divergent redox reactions that include common one‐electron reactions and a less‐common two‐electron redox event. Caution, we suggest, is warranted when utilising CS2 as a reactivity surrogate for CO2.
Experimental and modelling studies of MacKay River bitumen and light n‐alkane binaries
Authors: Zirrahi Mohsen , Hassanzadeh Hassan , Abedi Jalal 
Published: January 2017

AbstractSolubility of light n‐alkanes in bitumen as well as density and viscosity of the bitumen‐rich phase are the necessary data for simulation and study of the solvent‐aided thermal recovery processes of bitumen. This paper presents experimental data for MacKay River bitumen with n‐alkane solvents (methane, ethane, propane, and butane). The viscosity and density of the solvent saturated bitumen phase are measured to determine the effect of solvent dissolution on the thermo‐physical properties of bitumen. The solvent‐bitumen system is modelled using the Peng‐Robinson equation of state (PR‐EoS). Moreover, experimental viscosity and density data of solvent‐saturated bitumen are correlated. The effective density and viscosity of the dissolved solvent molecules are obtained using the experimental density and viscosity data for the bitumen‐solvent system.
Long‐term outcome following remote ischemic postconditioning during percutaneous coronary interventions—the RIP‐PCI trial long‐term follow‐up
Authors: Lavi Shahar , Abu‐Romeh Nour , Wall Sabrina , Alemayehu Mistre , Lavi Ronit 
Published: January 2017

The clinical value of ischemic conditioning during percutaneous coronary intervention (PCI) and mode of administration is controversial. Our aim was to assess the long‐term effect of remote ischemic postconditioning among patients undergoing PCI. We randomized 360 patients undergoing PCI who presented with a negative troponin T at baseline into 3 groups: 2 groups received remote ischemic postconditioning (with ischemia applied to the arm in 1 group and to the thigh in the other group), and the third group acted as a control group. Remote ischemic postconditioning was applied during PCI immediately following stent deployment, by 3, 5‐minute cycles of blood pressure cuff inflation to >200 mm Hg on the arm or thigh (20 mm Hg to the arm in the control), with 5‐minute breaks between each cycle. There were no differences in baseline characteristics among the 3 groups. Periprocedural myocardial injury occurred in 33% (P = 0.64). After 1 year, there was no difference between groups in death (P = 0.91), myocardial infarction (P = 0.78), or repeat revascularization (P = 0.86). During 3 years of follow‐up, there was no difference in death, myocardial infarction, and revascularization among the groups (P = 0.45). Remote ischemic postconditioning during PCI did not affect long‐term cardiovascular outcome. A similar effect was obtained when remote ischemia was induced to the upper or lower limb.ClinicalTrials.gov Identifier: NCT00970827
A Dual‐Modal SERS/Fluorescence Gold Nanoparticle Probe for Mitochondrial Imaging
Authors: Eling Charlotte J. , Price Thomas W. , Marshall Addison R. L. , Narda Viscomi Francesco , Robinson Peter , Firth George , Adawi Ali M. , Bouillard Jean‐Sebastien G. , Stasiuk Graeme J. 
Published: January 2017

AbstractA novel SERS/fluorescent multimodal imaging probe for mitochondria has been synthesised using 12 nm diameter gold nanoparticles (AuNP) surface functionalised with a rhodamine thiol derivative ligand. The normal pH‐dependent fluorescence of the rhodamine‐based ligand is inversed when it is conjugated with the AuNP and higher emission intensity is observed at basic pH. This switch correlates to a pKa at pH 6.62, which makes it an ideal candidate for a pH‐sensitive imaging probe in the biological range (pH 6.5–7.4). The observed pH sensitivity of the ligand when attached to the AuNP is thought to be due to the formation of a spirolactam ring, going from positively charged (+18 mV) to negatively charged (−60 mV) as the pH is changed from acidic to basic. Additionally, conjugation of the ligand to the AuNP serves to enhance the Raman signal of the rhodamine ligand through surface‐enhanced Raman scattering (SERS). Confocal microscopy has shown that the probe enters HEK293 (kidney), A2780 (ovarian cancer) and Min6 (pancreatic beta) cells within an hour and a half incubation time. The probe was shown to localise in the mitochondria, thus providing a novel pH‐dependent SERS/fluorescent multimodal imaging probe for mitochondria.