bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kongomania Redux, The Haitian Revolution: David Geggus Responds to John Thornton, Christina Mobley, and James Sweet
Authors: Geggus David 
Published: October 2024

AbstractDavid Geggus offers a detailed response to the three critiques of his “Kongomania” article by John Thornton, Christina Mobley, and James Sweet. Centered on demographic statistics and their link to cultural influence, the rebuttal examines evidentiary support for various assertions and hypotheses. The debate ranges over the use of certain ethnonyms (Creole, Congo, Mondongue); the creation of Vodou; the significance of Baudry des Lozières's Vocabulaire Congo; and the organization and aims of the 1791 uprising and the Haitian War of Independence.
Debating the Haitian Revolution and ‘Kongomania’: An African Rebellion on the Other Side of the Atlantic, or a French Creole Revolution in the Caribbean?
Authors: Childs Matt D. 
Published: October 2024

AbstractOver the past 30 years, scholarship has shifted from viewing the Haitian Revolution as largely an extension of the French Revolution to understanding it as a revolt from the perspective of Africa and Africans. Four related factors contribute to explanations of this change in perspective. First, historians trained in pre-colonial Africa began to study slavery in the Americas. The second factor is the emergence of Atlantic History as a field of study, the third is the Bicentennial commemorations of the start (1991) and the end (2004) of the Haitian Revolution, and the fourth is Michel-Rolph Trouillot's much celebrated, widely circulated, and extremely influential essay “Unthinkable History” (from Silencing the Past: Power and the Production of History; 1995), in which he critiqued the entire historiography of the Haitian Revolution and called for new perspectives. Taken collectively, the confluence of these four factors, all emerging prominently in the 1990s, contributed to the historiographical shift in Haitian scholarship that David Geggus labels “Kongomania.”The two main points of Geggus's contribution to this issue of The Americas is to challenge this recent understanding of the Haitian Revolution as essentially an African revolt in the Caribbean led by Kongos, and to give scholars reason to focus more attention on the active role of Creoles. Collectively, the responses by John Thornton, James H. Sweet, and Christina Mobley to Geggus's article emphasize that the point of their scholarship was to offer a Kongo perspective on the Haitian Revolution from their training and expertise in African history, not produce a new orthodoxy.
Comprehensive Comparison of Two Global Multi‐Species MHD Models of Mars
Authors: Sun Wenyi , Sakata Ryoya , Ma Yingjuan , Seki Kanako , Russell Christopher T. , Terada Naoki , Sakai Shotaro , Shinagawa Hiroyuki , Brain David , Toth Gabor 
Published: October 2024

AbstractUnderstanding the interaction between Mars and the solar wind is crucial for comprehending the atmospheric evolution and climate change on Mars. To gain a comprehensive understanding of the Martian plasma environment, global numerical simulations are essential in addition to spacecraft observations. However, there are still discrepancies among different simulation models. This study investigates how these discrepancies stem from the considered physical processes and numerical implementations. We compare two global multispecies MHD models: the “Sun model” based on the BATS‐R‐US code and the “Sakata model” based on a newly developed multifluid model MAESTRO. By employing the same typical upstream conditions and the same neutral atmosphere for current Mars, along with similar numerical implementations such as inner boundary conditions, we obtain simulation results that exhibit unprecedented agreement between the two models. The dayside results are nearly identical, especially along the subsolar line, indicating the robustness of MHD models to predict dayside interaction under given upstream conditions and ionosphere assumptions. The escape rates of planetary ions are also in good agreement. However, discrepancies remain in the terminator and nightside regions. Detailed numerical implementations, including inner boundary conditions, magnetic field divergence control methods, and radial resolutions, are shown to influence certain aspects of the results greatly, such as magnetotail configuration and ion diffusion.
The Global Biogeochemical Cycle of Rhenium
Authors: Ghazi L. , Grant K. E. , Chappaz A. , Danish M. , Peucker‐Ehrenbrink B. , Pett‐Ridge J. C. 
Published: October 2024

AbstractThis paper is the first comprehensive synthesis of what is currently known about the different natural and anthropogenic fluxes of rhenium (Re) on Earth's surface. We highlight the significant role of anthropogenic mobilization of Re, which is an important consideration in utilizing Re in the context of a biogeochemical tracer or proxy. The largest natural flux of Re derives from chemical weathering and riverine transport to the ocean (dissolved = 62 × 106 g yr−1 and particulate = 5 × 106 g yr−1). This review reports a new global average [Re] of 16 ± 2 pmol L−1, or 10 ± 1 pmol L−1 for the inferred pre‐anthropogenic concentration without human impact, for rivers draining to the ocean. Human activity via mining (including secondary mobilization), coal combustion, and petroleum combustion mobilize approximately 560 × 106 g yr−1 Re, which is more than any natural flux of Re. There are several poorly constrained fluxes of Re that merit further research, including: submarine groundwater discharge, precipitation (terrestrial and oceanic), magma degassing, and hydrothermal activity. The mechanisms and the main host phases responsible for releasing (sources) or sequestrating (sinks) these fluxes remain poorly understood. This study also highlights the use of dissolved [Re] concentrations as a tracer of oxidation of petrogenic organic carbon, and stable Re isotopes as proxies for changes in global redox conditions.
The Interdecadal Changes of the Relationship Between May‐June and July‐August NWPSH and Their Physical Mechanisms
Authors: Li Shuai , Kucharski Fred , Yang Jie , Gong ZhiQiang , Zhao Yuxuan , Feng Guolin 
Published: October 2024

AbstractUnlike prior researches focusing on interannual or interdecadal changes of the Northwest Pacific subtropical high (NWPSH), this paper emphasizes the interdecadal changes in the relationship between May‐June and July‐August NWPSH. The correlation coefficients between them are 0.66 (passing the 99.9% confidence level) and 0.12 during 1979–2002 and 2003–2023. Therefore, the May‐June NWPSH has a strong connection with July‐August East Asian precipitation during 1979–2002, but not during 2003–2023. The interdecadal variations in the relationship of NWPSH are due to interdecadal changes of ENSO. During 1979–2002, the eastern‐type ENSO in prior winter, having longer durations, can influence May‐June and July‐August NWPSH and the North Indian Ocean. However, the central‐type ENSO in prior winter only persists it's influence until May‐June, and changes into a Pacific Dipole pattern in July‐August during 2003–2023. Despite the North Indian Ocean continually warms during 2003–2023, the tropical Pacific Dipole offsets its impacts on the NWPSH.
Fire in Feces: Bats Reliably Record Fire History in Their Guano
Authors: Tsalickis Alexandra , Vachula Richard S. , Welch J. Conner , Campbell Joshua W. , Waters Matthew N. 
Published: October 2024

AbstractNew approaches are needed to resolve persistent geographic gaps and biases in paleofire research. Most sedimentary paleofire research relies on lake and peat sediments. We present an unconventional sedimentary charcoal record preserved in a modern, post‐bomb bat guano deposit and compare its accumulation to historical fire data. We find strong correlations between charcoal accumulation rates (CHAR) and non‐winter prescribed burns. CHAR in bat guano is more strongly correlated with prescribed fire than wildfire or total area burned, likely due to bats seeking out areas burned by prescribed fire for better foraging opportunities and/or bats avoiding wildfire. We attribute the CHAR in guano being a better recorder of area burned during non‐winter months to winter bat hibernation. Our analyses show that charcoal preserved in bat guano is a reliable paleofire proxy system, which has important implications for the paleofire field and encourages future research using bat guano as a viable archive.
Two‐Streams Revisited: General Equations, Exact Coefficients, and Optimized Closures
Authors: Ho Dion J. X. , Pincus Robert 
Published: October 2024

AbstractTwo‐Stream Equations are the most parsimonious general models for radiative flux transfer with one equation to model each of upward and downward fluxes; these are coupled due to the transfer of fluxes between hemispheres. Standard two‐stream approximation of the Radiative Transfer Equation assumes that the ratios of flux transferred (coupling coefficients) are both invariant with optical depth and symmetric with respect to upwelling and downwelling radiation. Two‐stream closures are derived by making additional assumptions about the angular distribution of the intensity field, but none currently works well for all parts of the optical parameter space. We determine the exact values of the two‐stream coupling coefficients from multi‐stream numerical solutions to the Radiative Transfer Equation for shortwave radiation. The resulting unique coefficients accurately reconstruct entire flux profiles but depend on optical depth. More importantly, they generally take on unphysical values when symmetry is assumed. We derive a general form of the Two‐Stream Equations for which the four coupling coefficients are guaranteed to be physically explicable. While non‐constant coupling coefficients are required to reconstruct entire flux profiles, numerically optimized constant coupling coefficients (which admit analytic solutions) reproduced shortwave reflectance and transmittance with relative errors no greater than over a large range of optical parameters. The optimized coefficients show a dependence on solar zenith angle and total optical depth that diminishes as the latter increases. This explains why existing coupling coefficients, which often omit the former and mostly neglect the latter, tend to work well for only thin or only thick atmospheres.
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders
Authors: Song Yi , Li Jian , Wu Yuzhang 
Published: October 2024

AbstractAutoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body’s own components, resulting in tissue destruction and organ dysfunction. Autoimmune diseases affect a wide range of people in many parts of the world and have become one of the major concerns in public health. In recent years, there have been substantial progress in our understanding of the epidemiology, risk factors, pathogenesis and mechanisms of autoimmune diseases. Current approved therapeutic interventions for autoimmune diseases are mainly non-specific immunomodulators and may cause broad immunosuppression that leads to serious adverse effects. To overcome the limitations of immunosuppressive drugs in treating autoimmune diseases, precise and target-specific strategies are urgently needed. To date, significant advances have been made in our understanding of the mechanisms of immune tolerance, offering a new avenue for developing antigen-specific immunotherapies for autoimmune diseases. These antigen-specific approaches have shown great potential in various preclinical animal models and recently been evaluated in clinical trials. This review describes the common epidemiology, clinical manifestation and mechanisms of autoimmune diseases, with a focus on typical autoimmune diseases including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and sjögren’s syndrome. We discuss the current therapeutics developed in this field, highlight the recent advances in the use of nanomaterials and mRNA vaccine techniques to induce antigen-specific immune tolerance.
Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 study
Authors: Gu Liangyou , Peng Cheng , Liang Qiyang , Huang Qingbo , Lv Deqiang , Zhao Houming , Zhang Qi , Zhang Yu , Zhang Peng , Li Shichao , Xu Junnan , Chen Luyao , Xie Yongpeng , Li Jinhang , Guo Gang , Zhang Xu , Wang Baojun , Ma Xin 
Published: October 2024

AbstractThe potential benefit of neoadjuvant toripalimab plus axitinib in cases with clear cell renal cell carcinoma (ccRCC) and inferior vena cava tumor thrombus (IVC-TT) remains unclear. NEOTAX was a phase 2 study to investigate the efficacy and safety of neoadjuvant toripalimab plus axitinib in patients with ccRCC and IVC-TT (ChiCTR2000030405). The primary endpoint was the down-staging rate of IVC-TT level. Secondary endpoints included change in TT length, response rate, percentage change in surgical approach, surgical morbidity, progression-free survival (PFS), safety, and biomarker analyses. In all, 25 patients received study treatment, 44.0% (11/25) patients had a reduction in thrombus level, and none experienced an increase in Mayo level. The median change in tumor thrombus length was −2.3 cm (range: −7.1 to 1.1 cm). Overall, 61.9% (13/21) patients experienced changes in surgical strategy compared with planned surgery, three patients experienced major complications. The median PFS was 25.3 months (95% CI: 17.0-NE). The 1-year PFS was 89.1% (95% CI: 62.7–97.2). No any of grade 4 or 5 treatment-related adverse event was identified. Biopsy samples of non-responders exhibited increased T cytotoxic cell infiltration, but these cells were predominantly PD-1 positive. Biopsy samples of responders exhibited lower T helper cells, however, their subtype, regulatory T cells remained unchanged. In surgical samples of the TT, non-responders exhibited increased CD8T_01_GZMK_CXCR4 subset T cells. NEOTAX met preset endpoints proving that toripalimab in combination with axitinib downstages IVC-TT in a significant proportion of patients leading to simplification in the procedure of surgery.
Regulation of HNRNP family by post-translational modifications in cancer
Authors: Li Bohao , Wen Mingxin , Gao Fei , Wang Yunshan , Wei Guangwei , Duan Yangmiao 
Published: October 2024

AbstractHeterogeneous nuclear ribonucleoproteins (HNRNPs) represent a large family of RNA-binding proteins consisting of more than 20 members and have attracted great attention with their distinctive roles in cancer progression by regulating RNA splicing, transcription, and translation. Nevertheless, the cancer-specific modulation of HNRNPs has not been fully elucidated. The research of LC-MS/MS technology has documented that HNRNPs were widely and significantly targeted by different post-translational modifications (PTMs), which have emerged as core regulators in shaping protein functions and are involved in multiple physiological processes. Accumulating studies have highlighted that several PTMs are involved in the mechanisms of HNRNPs regulation in cancer and may be suitable therapeutic targets. In this review, we summarize the existing evidence describing how PTMs modulate HNRNPs functions on gene regulation and the involvement of their dysregulation in cancer, which will help shed insights on their clinical impacts as well as possible therapeutic tools targeting PTMs on HNRNPs.
Burst plasma preparation of metallic nanoparticles on carbon fabrics for antibacterial and electrocatalytic applications
Authors: Xu Guiyin , Meng Zheyi , Cao Yunteng , Tao Zixu , Li Qing-Jie , Stapelberg Myles , Han Bing , Gao Rui , Yu Qipeng , Gu Meng , Marelli Benedetto , Wang Hailiang , Zhu Meifang , Li Ju 
Published: October 2024

Abstract
Metal nanoparticles have extraordinary properties, but their integration into mesostructures has been challenging. Producing uniformly dispersed nanoparticles attached to substrates in industrial quantities is difficult. Herein, a “plasmashock” method was developed to synthesize metal nanoparticles anchored on different types of carbonaceous substrates using liquid salt solution precursors. These self-supporting, nanoparticle-loaded carbon fabrics are mechanically robust and have been tested as antibacterial substrates and electrocatalysts for reducing carbon dioxide and nitrite. A piece of silver–carbon nanotube paper with a silver loading of ~0.13 mg cm−2 treated after a few-second plasmashock presents good antibacterial and electrocatalytic properties in wastewater, even after 20 bactericidal immersion cycles, due to the strong bonding of the nanoparticles to the substrate. The results prove the effectiveness of this plasmashock method in creating free-standing functional composite films or membranes.
Adaptation of a methanogen to Fe0 corrosion via direct contact
Authors: Kawaichi Satoshi , Kotoky Rhitu , Fiutowski Jacek , Rotaru Amelia-Elena 
Published: October 2024

AbstractDue to unique genomic adaptations, Methanococcus maripaludis Mic1c10 is highly corrosive when in direct contact with Fe0. A critical adaptation involves increased glycosylation of an extracellular [NiFe]-hydrogenase, facilitating its anchoring to cell surface proteins. Corrosive strains adapt to the constructed environment via horizontal gene transfer while retaining ancestral genes important for intraspecies competition and surface attachment. This calls for a reevaluation of how the built environment impacts methane cycling.
The impact of gravity on perceived object height
Authors: Jörges Björn , Bury Nils , McManus Meaghan , Bansal Ambika , Allison Robert S. , Jenkin Michael , Harris Laurence R. 
Published: October 2024

AbstractAltering posture relative to the direction of gravity, or exposure to microgravity has been shown to affect many aspects of perception, including size perception. Our aims in this study were to investigate whether changes in posture and long-term exposure to microgravity bias the visual perception of object height and to test whether any such biases are accompanied by changes in precision. We also explored the possibility of sex/gender differences. Two cohorts of participants (12 astronauts and 20 controls, 50% women) varied the size of a virtual square in a simulated corridor until it was perceived to match a reference stick held in their hands. Astronauts performed the task before, twice during, and twice after an extended stay onboard the International Space Station. On Earth, they performed the task of sitting upright and lying supine. Earth-bound controls also completed the task five times with test sessions spaced similarly to the astronauts; to simulate the microgravity sessions on the ISS they lay supine. In contrast to earlier studies, we found no immediate effect of microgravity exposure on perceived object height. However, astronauts robustly underestimated the height of the square relative to the haptic reference and these estimates were significantly smaller 60 days or more after their return to Earth. No differences were found in the precision of the astronauts’ judgments. Controls underestimated the height of the square when supine relative to sitting in their first test session (simulating Pre-Flight) but not in later sessions. While these results are largely inconsistent with previous results in the literature, a posture-dependent effect of simulated eye height might provide a unifying explanation. We were unable to make any firm statements related to sex/gender differences. We conclude that no countermeasures are required to mitigate the acute effects of microgravity exposure on object height perception. However, space travelers should be warned about late-emerging and potentially long-lasting changes in this perceptual skill.
Tailoring the natural rare sugars D-tagatose and L-sorbose to produce novel functional carbohydrates
Authors: Hernandez-Hernandez Oswaldo , Sabater Carlos , Calvete-Torre Inés , Doyagüez Elisa G. , Muñoz-Labrador Ana M. , Julio-Gonzalez Cristina , de las Rivas Blanca , Muñoz Rosario , Ruiz Lorena , Margolles Abelardo , Mancheño José M. , Moreno F. Javier 
Published: October 2024

AbstractThis multidisciplinary study details the biosynthesis of novel non-digestible oligosaccharides derived from rare sugars, achieved through transfructosylation of D-tagatose and L-sorbose by levansucrase from Bacillus subtilis CECT 39 (SacB). The characterization of these carbohydrates using NMR and molecular docking was instrumental in elucidating the catalytic mechanism and substrate preference of SacB. Tagatose-based oligosaccharides were higher in abundance than L-sorbose-based oligosaccharides, with the most representative structures being: β-D-Fru-(2→6)-β-D-Fru-(2→1)-D-Tag and β-D-Fru-(2→1)-D-Tag. In vitro studies demonstrated the resistance of tagatose-based oligosaccharides to intestinal digestion and their prebiotic properties, providing insights into their structure-function relationship. β-D-Fru-(2→1)-D-Tag was the most resistant structure to small-intestinal digestion after three hours (99.8% remained unaltered). This disaccharide and the commercial FOS clustered in similar branches, indicating comparable modulatory properties on human fecal microbiota, and exerted a higher bifidogenic effect than unmodified tagatose. The bioconversion of selected rare sugars into β-fructosylated species with a higher degree of polymerization emerges as an efficient strategy to enhance the bioavailability of these carbohydrates and promote their interaction with the gut microbiota. These findings open up new opportunities for tailoring natural rare sugars, like D-tagatose and L-sorbose, to produce novel biosynthesized carbohydrates with functional and structural properties desirable for use as emerging prebiotics and low-calorie sweeteners.
Plateau depolarizations in spontaneously active neurons detected by calcium or voltage imaging
Authors: Milicevic Katarina D. , Ivanova Violetta O. , Lovic Darko D. , Platisa Jelena , Andjus Pavle R. , Antic Srdjan D. 
Published: October 2024

AbstractIn calcium imaging studies, Ca2+ transients are commonly interpreted as neuronal action potentials (APs). However, our findings demonstrate that robust optical Ca2+ transients primarily stem from complex “AP-Plateaus”, while simple APs lacking underlying depolarization envelopes produce much weaker photonic signatures. Under challenging in vivo conditions, these “AP-Plateaus” are likely to surpass noise levels, thus dominating the Ca2+ recordings. In spontaneously active neuronal culture, optical Ca2+ transients (OGB1-AM, GCaMP6f) exhibited approximately tenfold greater amplitude and twofold longer half-width compared to optical voltage transients (ArcLightD). The amplitude of the ArcLightD signal exhibited a strong correlation with the duration of the underlying membrane depolarization, and a weaker correlation with the presence of a fast sodium AP. Specifically, ArcLightD exhibited robust responsiveness to the slow “foot” but not the fast “trunk” of the neuronal AP. Particularly potent stimulators of optical signals in both Ca2+ and voltage imaging modalities were APs combined with plateau potentials (AP-Plateaus), resembling dendritic Ca2+ spikes or “UP states” in pyramidal neurons. Interestingly, even the spikeless plateaus (amplitude > 10 mV, duration > 200 ms) could generate conspicuous Ca2+ optical signals in neurons. Therefore, in certain circumstances, Ca2+ transients should not be interpreted solely as indicators of neuronal AP firing.