bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Indeks Stigma Terhadap Penyakit HIV di RSUD Dr. M. Yunus bengkulu
Authors: Dwina Natalia , Supriyatna Rahmat , Sabdani Halian 
Published: October 2024

HIV yaitu virus yang menyerang dan melemahkan system pertahanan tubuh manusia, sehingga mudah tertular berbagai penyakit. AIDS yaitu sekumpulan gejala penyakit akibat menurunnya kekebalan tubuh yang disebabkan oleh HIV. ODHA (Orang Dengan HIV/AIDS) adalah sebutan bagi orang yang telah positif HIV/AIDS. Tujuan penelitian diperolehnya informasi mendalam tentang Indeks Stigma Orang yang Hidup dengan HIV (ODHIV)adalah alat standar untuk mengumpulkan bukti tentang bagaimana stigma dan diskriminasi berdampak pada kehidupan orang yang hidup dengan HIV. di lingkungan RSUD dr. M. Yunus Bengkulu terhadap Orang dengan HIV/AIDS (ODHA) . Penelitian ini menggunakan Focus Group Discussion (FGD) sebagai teknik utama untuk pengumpulan data.yang menggunakan pendekatan kualitatif dengan teknik pengumpulan darta melalui wawancara dan observasi serta menerapkan metode triangulasi bertujuan untuk memberikan kepercayaan dan validitas yang lebih tinggi terhadap temuan penelitian dengan mengintegrasikan sudut pandang yang berbeda dan mengurangi bias yang mungkin timbul dari satu sumber data atau metode saja. Sumber data terdiri dari 15 informan, yang dibagi menjadi 5 informan utama (Orang Dengan HIV AIDS), 5 informan kunci (Pengunjung Rumah Sakit), dan 5 Informan pendukung. (Nakes/Petugas Rumah Sakit). Tujuan Penelitian ini untuk melihat apakah masih ada Indeks Stigma yang terjadi di RSUD dr. M. Yunus Bengkulu, dan hasil penelitian menunjukkan bahwa pengetahuan tentang penyakit HIV/AIDS masih rendah di kalangan pengunjung Rumah Sakit, Pasien HIV Sendiri, juga Sebagain Nakes/Petugas Rumah Sakit, Sebagai saran, penelitian menyarankan agar pihak RSUD dr. M. Yunus aktif dalam memberikan penyuluhan mengenai HIV/AIDS kepada seluruh pihak di lingkungan RSUD, termasuk petugas, pasien, dan pengunjung, sehingga semua orang di lingkungan RSUD dapat mendapatkan informasi yang akurat dan mengurangi stigma terhadap ODHA.
Criterios clínicos y radiológicos de los tratamientos endodónticos para rehabilitación Endocrown: meta análisis
Authors: Astudillo Benavides Domenica Camila , Piedra Andrade Rafael Bernardo , Pesantez Coronel Amanda Isabel , Torrachi Carrasco Jose Esteban 
Published: October 2024

Introducción: La endodoncia se centra en diagnosticar y tratar enfermedades pulpares y de tejido periapical, limpiando microorganismos y modelando el conducto para un adecuado sellado. Un diagnóstico preciso es esencial para elegir la rehabilitación que recupere la funcionalidad y estética del diente. Tras el tratamiento, es crucial evaluar la pérdida estructural para seleccionar la rehabilitación adecuada. Aunque se usaban pernos, estos pueden causar fracturas en la raíz por mala distribución de fuerzas, especialmente en molares y premolares. Como alternativa, se proponen las endocoronas para una rehabilitación post-endodóntica más efectiva. Objetivo: Establecer los criterios clínicos y radiológicos de los tratamientos endodónticos para endocrown mediante un meta análisis. Metodología: Se realizó una revisión sistemática exhaustiva en diferentes bases de datos como Pubmed, Scielo, Scorpus, Web of Science entre otros. Los datos se determinaron mediante la estandarización con el sistema de Microsoft Office Excel 2016. En cuanto a los estudios se tabularon con los siguientes datos: Autor, año de publicación, resumen, introducción, métodos, resultados, discusión y otra información, de acuerdo con la declaración de PRISMA y Consort Modificated. Los artículos analizados fueron evaluados de acuerdo con la guía de Cochrane, con los ítems de sesgo de selección, sesgo de realización, sesgos de detección y sesgo de datos incompletos. Resultados: Las diferencias medias estandarizadas observadas oscilaron entre 0,0273 y 1,4852, siendo la mayoría de las estimaciones positivas, la diferencia media estandarizada promedio estimada basada en el modelo de efectos aleatorios fue \hat{\mu} = 0,6425 (IC del 95 %: 0,0496 a 1,2354). Por lo tanto, el resultado promedio difirió significativamente de cero (z = 2,1239, p = 0,0337). La prueba Q para la heterogeneidad no fue significativa, pero aún puede haber cierta heterogeneidad en los resultados verdaderos (Q(4) = 8,5752, p = 0,0726, tau² 0,2431, I² = 53,6752%). Conclusión: Se ha terminado que no existe una diferencia significativa estadística entre la restauración de endocrown con la conservadora desde la perspectiva de los criterios endodónticos establecidos. Área de estudio general: Odontología. Área de estudio específica: Endodoncia. Tipo de estudio: Revisión bibliográfica/ Bibliographic review.
KARAKTERISTIK PENDERITA TUBERKULOSIS PARU KAMBUH DI RSUD DR. H. CHASAN BOESOIRIE
Authors: Abubakar Ummuhani , Masrika Nur Upik En, 
Published: October 2024

Indonesia menempati urutan tertinggi kedua jumlah penderita tuberkulosis terbanyak di dunia. Namun data tersebut belum mencerminkan presentasi kasus baru maupun kambuh. Penelitian terkait tuberkulosis paru kambuh belum pernah dilakukan di Maluku Utara. Tujuan penelitian ini untuk mengetahui karakteristik penderita tuberkulosis paru kambuh di Rumah Sakit Utama Provinsi Maluku Utara. Metode penelitian observasional deskriptif retrospektif ini dilakukan pada poliklinik paru RSUD Dr. H. Chasan Boesoirie Ternate berdasarkan data rekam medis dari tahun 2016 – 2021. Hasil penelitian menunjukkan dari 19 penderita, 21% termasuk ke dalam kelompok usia 26 – 35 tahun dan 46 – 55 tahun, 63% berjenis kelamin laki – laki, 68,4% menempuh pendidikan terakhir di SMA, 26,3% bekerja sebagai wiraswasta, 57,9% tanpa penyakit penyerta, 57,9% memiliki riwayat merokok, dan 57,9% tidak teratur minum obat. Tuberkulosis paru kambuh paling banyak terjadi pada kelompok umur 26 – 35 tahun dan 46 – 55 tahun, paling banyak terjadi pada penderita dengan jenis kelamin laki – laki, berpendidikan terakhir SMA, bekerja sebagai wiraswasta, sebagian besar tidak mempunyai penyakit penyerta, paling banyak memiliki riwayat merokok dan tidak teratur minum obat.
Translanguaging and Decolonisation in South African Higher Education: Embracing Multilingual Pedagogies
Authors: Mbirimi-Hungwe Vimbai , Matariro-Mutanha Mariyeni 
Published: October 2024

Translanguaging, a practice that recognises and utilizes multilingual students’ linguistic repertoires has emerged as a crucial approach in challenging traditional language policies, particularly in the South African educational landscape.Despite its embrace, a colonial stance still persists in teaching practices. Through a critical analysis of teaching materials used in an academic literacy course, this paper explores how translanguaging is currently being used in teaching and learning. Findings reveal a tension in the sense that even though students’ language practices are acknowledged, the materials still maintain a dominant position for English. This highlights the need to move beyond a simplistic view of multilingualism towards a more holistic embrace of translanguaging.Set against this background, this research argues that translanguaging can bridge the abyssal divide created by colonialism. It emphasizes the unifying potential of translanguaging, fostering an educational landscape that celebrates South Africa's rich linguistic diversity and cultural heritage. Ultimately, the study calls upon educators to move beyond the limitations of standardized languages and fully embrace translanguaging as a transformative force for decolonization.At the end, the paper calls for further research.
Community-Inquiry: Current Perspectives on Freshmen’s Verbal and Written Feedback from Sophomores Students of EFL Writing
Authors: Hanifiyah Lina , Ivone Francisca Maria , Rachmajanti Sri 
Published: October 2024

A community of inquiry can help students increase engagement that supports English language acquisition. The community- inquiry provides students not only with cognitive but also social intelligence. Therefore, this study aimed to explore the perceptions of sophomores' verbal and written feedbacks on freshmen’s writing. This small-scale study examined 25 students attending an Intensive English Course in the English Literature Department at Universitas Islam Negeri Maulana Malik Ibrahim Malang. It involved sophomores providing verbal and written feedbacks on freshmen's writing, reflecting the implementation of a community of inquiry. The study employed a case study method, using three types of questionnaires to gather students' opinions on sophomores' written feedbacks, their perceptions of the verbal feedbacks, and their descriptive writing competence following the feedback process. The study revealed that both the sophomores' verbal and written feedbacks were beneficial for improving the freshmen's writing skills. Furthermore, the process of receiving feedbacks also appeared to enhance the students' confidence in their writing.Verbal and written feedback from the sophomores not only clarifies the aspects for the improvement of the composition but also improves the freshmen’s self-confidence to write better. The feedbacks are effective since the students are of the same age, the freshmen can relate better, and the feedback they receive matches their style. However, this type of mentorship also has drawbacks because the sophomores’ knowledge is limited, so the input they can provide is also limited. Therefore, it is suggested that English lecturers take advantage of sophomores' verbal and written feedbacks to assist freshmen in developing their writing skills.
Aeromedical Considerations for Patient Safety in Aesthetic Medical Tourism
Authors: Hoyos Alfredo E. , Ramirez Brian , Benavides Jorge , Perez Pachon Mauricio E. , Varela Agustina 
Published: October 2024

INTRODUCTION: The global rise in aesthetic surgery has led to an increase in aesthetic medical tourism (AMT). As patients pursue surgical interventions abroad, concerns about the elevated complication rates in AMT have emerged. This study explores the complexities of AMT, emphasizing the intersection of plastic surgery and aerospace medicine, to elucidate the incidence of complications, identify associated variables, and introduce aeromedical considerations to proactively enhance patient safety.
METHODS: A comprehensive retrospective observational cohort study was conducted using data spanning 2004 to 2023 from a private plastic surgery practice in Bogota, Colombia. The study included 3367 patients, of whom 26% were international patients. Sociodemographic and clinical variables, flight details, and surgical complications were analyzed. Statistical analyses involved descriptive statistics, odds ratios, and multiple regression analyses.
RESULTS: Of the 865 AMT patients, 75 exhibited complications. Infection and wound dehiscence were the most prevalent; no severe complications or mortality was reported. The study revealed that AMT patients have a higher risk of complications compared to those locally treated (adjusted odds ratio = 4.6; 95% confidence interval = 2.6–8.2). Flight time exceeding 4 h was a factor associated with nonaesthetic complications.
DISCUSSION: This study reveals that AMT is linked to a higher risk of nonaesthetic complications, with flight duration being a significant contributing factor. Despite the increased risk, complication rates for AMT patients did not surpass thresholds reported in the literature; this may be attributed to the safety protocols implemented. Aeromedical considerations played a crucial role in mitigating physiological stress associated with air travel.
Hoyos AE, Ramirez B, Benavides J, Perez Pachon ME, Varela A. Aeromedical considerations for patient safety in aesthetic medical tourism. Aerosp Med Hum Perform. 2024; 95(10):765–770.
Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors
Authors: Tey Sin-Ruow , Anderson Ryan S. , Yu Clara H. , Robertson Samantha , Kletzien Heidi , Connor Nadine P. , Tanaka Kaori , Ohkawa Yasuyuki , Suzuki Masatoshi 
Published: October 2024

IntroductionThe changing composition of non-cell autonomous circulating factors in blood as humans age is believed to play a role in muscle mass and strength loss. The mechanisms through which these circulating factors act in age-related skeletal muscle changes is not fully understood. In this study, we used human myogenic progenitors derived from human pluripotent stem cells to study non-cell autonomous roles of circulating factors during the process of myogenic differentiation.MethodsMyogenic progenitors from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) were supplemented with serum samples from aged or young Fischer 344 × Brown Norway F1-hybrid rats. The effect of aged or young serum supplementation on myogenic progenitor proliferation, myotube formation capacity, differentiation, and early transcriptomic profiles were analyzed.ResultsWe found that aged rat serum supplementation significantly reduced cell proliferation and increased cell death in both ESC- and iPSC-derived myogenic progenitors. Next, we found that the supplementation of aged rat serum inhibited myotube formation and maturation during terminal differentiation from progenitors to skeletal myocytes when compared to the cells treated with young adult rat serum. Lastly, we identified that gene expression profiles were affected following serum supplementation in culture.DiscussionTogether, aged serum supplementation caused cellular and transcriptomic changes in human myogenic progenitors. The current data from our in vitro model possibly simulate non-cell autonomous contributions of blood composition to age-related processes in human skeletal muscle.
Global research trends and hotspots on human intestinal fungi and health: a bibliometric visualization study
Authors: Gong Ming , Yu Huiying , Qu Hong , Li Zhexian , Liu Di , Zhao Xin 
Published: October 2024

BackgroundThis article employs bibliometric methods and visual maps to delineate the research background, collaborative relationships, hotspots, and trends in the study of gut fungi in human diseases and health.MethodsPublications related to human gut fungi were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, R software and Microsoft Excel were employed to generate visual representations illustrating the contributions made by countries/regions, authors, organizations, and journals. Employing VOSviewer and CiteSpace, we conducted a comprehensive analysis of the retrieved publications, revealing underlying tendencies, research hotspots, and intricate knowledge networks.ResultsThis study analyzed a total of 3,954 publications. The United States ranks first in the number of published papers and has the highest number of citations and h-index. Mostafa S Elshahed is the most prolific author. The University of California System is the institution that published the most papers. Frontiers In Microbiology is the journal with the largest number of publications. Three frequently co-cited references have experienced a citation burst lasting until 2024.ConclusionAdvancements in sequencing technologies have intensified research into human gut fungi and their health implications, shifting the research focus from gut fungal infections towards microbiome science. Inflammatory bowel diseases and Candida albicans have emerged as pivotal areas of interest in this endeavor. Through this study, we have gained a deeper insight into global trends and frontier hotspots within this field, thereby enhancing our understanding of the intricate relationship between gut fungi and human health.
Coronary obstruction analysis in transcatheter aortic valve implantation through patient-specific computational modelling
Authors: Fan Jiaqi , Chen Jun , Wang Lihan , Hu Po , Jiang Jubo , Lin Xinping , Rocatello Giorgia , De Beule Matthieu , Tie Yi , Wang Yifei , Cheng Sihang , Liu Xianbao , Wang Jian’an 
Published: October 2024

BackgroundCoronary obstruction (CO) is a rare but devasting complication during transcatheter aortic valve replacement (TAVR).ObjectivesWe aim to demonstrate that the predicted distance between the coronary ostia and the closest structure derived with patient-specific computer simulation is associated with CO risk during TAVR.MethodsWe retrospectively analysed 14 aortic stenosis patients who underwent TAVR through finite element simulation. The frame deformation predicted with patient-specific computer simulation was qualitatively and quantitatively compared to the post-operative device deformation. The minimum distance between each coronary ostium and the closest structure was calculated and compared in patients who developed CO, at high risk of CO, and at no risk of CO.ResultsFour patients experienced CO during TAVR, 5 patients were at high risk of CO, and the remaining 5 patients had no risk of CO. A high coefficient of determination was obtained for all measurements extracted from the simulated device and the post-operative device (≥0.95). Simulations predicted shorter distance between the coronary ostium and the closest structure in patients who experienced CO, compared to patients at high risk of CO or who did not experience this complication (right coronary: 5.9 vs. 6.8 vs. 8.8 mm, left coronary: 3.0 vs. 3.3 vs. 6.5 mm respectively).ConclusionsThe distance between the coronary ostium and the closest structure was lower in patients who experienced CO during TAVR through patient-specific computational simulation. This technology enables coronary obstruction analysis before TAVR in the future.
Sex hormone-binding globulin promotes the osteogenic differentiation potential of equine adipose-derived stromal cells by activating the BMP signaling pathway
Authors: Irwin-Huston Jennifer M. , Bourebaba Lynda , Bourebaba Nabila , Tomal Artur , Marycz Krzysztof 
Published: October 2024

BackgroundMusculoskeletal injuries and chronic degenerative diseases pose significant challenges in equine health, impacting performance and overall well-being. Sex Hormone-Binding Globulin (SHBG) is a glycoprotein determining the bioavailability of sex hormones in the bloodstream, and exerting critical metabolic functions, thus impacting the homeostasis of many tissues including the bone.MethodsIn this study, we investigated the potential role of SHBG in promoting osteogenesis and its underlying mechanisms in a model of equine adipose-derived stromal cells (ASCs). An SHBG-knocked down model has been established using predesigned siRNA, and cells subjected to osteogenic induction medium in the presence of exogenous SHBG protein. Changes in differentiation events where then screened using various analytical methods.ResultsWe demonstrated that SHBG treatment enhances the expression of key osteoconductive regulators in equine ASCs CD34+ cells, suggesting its therapeutic potential for bone regeneration. Specifically, SHBG increased the cellular expression of BMP2/4, osteocalcin (OCL), alkaline phosphatase (ALP), and osteopontin (OPN), crucial factors in early osteogenesis. Furthermore, SHBG treatment maintained adequate apoptosis and enhanced autophagy during osteogenic differentiation, contributing to bone formation and remodeling. SHBG further targeted mitochondrial dynamics, and promoted the reorganization of the mitochondrial network, as well as the expression of dynamics mediators including PINK, PARKIN and MFN1, suggesting its role in adapting cells to the osteogenic milieu, with implications for osteoblast maturation and differentiation.ConclusionOverall, our findings provide novel insights into SHBG’s role in bone formation and suggest its potential therapeutic utility for bone regeneration in equine medicine.
Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model
Authors: Hu Ling , Qiu Ming-Jing , Fan Wen-Juan , Wang Wan-Er , Liu Shao-Hao , Liu Xiao-Qi , Liu Shi-Wei , Shen Ze-Jin , Zheng Ya-Fei , Liu Guang-Chao , Jia Zi-Yi , Wang Xiao-Qing , Fang Na 
Published: October 2024

BackgroundThe pivotal responsibility of GABAergic interneurons is inhibitory neurotransmission; in this way, their significance lies in regulating the maintenance of excitation/inhibition (E/I) balance in cortical circuits. An abundance of glucocorticoids (GCs) exposure results in a disorder of GABAergic interneurons in the prefrontal cortex (PFC); the relationship between this status and an enhanced vulnerability to neuropsychiatric ailments, like depression and anxiety, has been identified, but this connection is still poorly understood because systematic and comprehensive research is lacking. Here, we aim to investigate the impact of dexamethasone (DEX, a GC receptor agonist) on GABAergic interneurons in the PFC of eight-week-old adult male mice.MethodsA double-blind study was conducted where thirty-two mice were treated subcutaneously either saline or DEX (0.2 mg/10 ml per kg of body weight) dissolved in saline daily for 21 days. Weight measurements were taken at five-day intervals to assess the emotional changes in mice as well as the response to DEX treatment. Following the 21-day regimen of DEX injections, mice underwent examinations for depression/anxiety-like behaviours and GABAergic marker expression in PFC.ResultsIn a depression/anxiety model generated by chronic DEX treatment, we found that our DEX procedure did trigger depression/anxiety-like behaviors in mice. Furthermore, DEX treatment reduced the expression levels of a GABA-synthesizing enzyme (GAD67), Reelin, calcium-binding proteins (parvalbumin and calretinin) and neuropeptides co-expressed in GABAergic neurons (somatostatin, neuropeptide Y and vasoactive intestinal peptide) in the PFC were reduced after 21 days of DEX treatment; these reductions were accompanied by decreases in brain size and cerebral cortex thickness.ConclusionOur results indicate that a reduction in the number of GABAergic interneurons may result in deficiencies in cortical inhibitory neurotransmission, potentially causing an E/I imbalance in the PFC; this insight suggests a potential breakthrough strategy for the treatment of depression and anxiety.