bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between ACE Gene Polymorphism and QT Dispersion in Patients with Acute Myocardial Infarction
Authors: Karahan Zulkuf , Ugurlu Murat , Ucaman Berzal , Veysel Ulug Ali , Kaya Ilyas , Cevik Kemal , Sahin Adiyaman Mehmet , Oztürk Onder , Iyem Hikmet , Ozdemir Ferit 
Published: May 2016

Background:
Angiotensin converting enzyme (ACE) gene polymorphism is associated with high renin-angiotensin system causing myocardial fibrosis and ventricular repolarization abnormality. Based on these findings, this study was designed to determine the association between ACE gene insertion/deletion (I/D) polymorphism and QT dispersion after acute myocardial infarction (MI).

Objective and Methods:
The study included 108 patients with acute MI. Blood samples were obtained from all the patients for genomic DNA analysis. ECGs were recorded at baseline and at the end of a 6-month follow up. The OT dispersion was manually calculated.

Results:
The mean age of the patients was 57.5 ±9.9 years (ranging from 36 to 70). The
patients with DD genotype showed longer QT dispersion than patients with II or
DI genotype at the baseline, while at the end of the six-month follow up the
patients with DI genotype showed longer QT dispersion than patients with DD or
II genotypes. However, the magnitude of the QT dispersion prolongation was
higher in patients carrying the ACE D allele than patients who were not carrying
it, at baseline and at the end of six-month follow up (52.5 ±2.6 msn vs.
47.5±2.1 msn at baseline, 57±3.2 msn vs. 53±2.6 msn in months, P: 0.428 and
P: 0.613, respectively).

Conclusion:
Carriers of the D allele of ACE gene I/D polymorphism may be associated with QT dispersion prolongation in patients with MI.An interaction of QT dispersion and ACE gene polymorphism may be associated with an elevation of serum type I-C terminal pro-collagen concentration, possibly leading to myocardial fibrosis, and increased action potential duration.
Orthodontic Treatment of Malocclusion and its Impact on Oral Health-Related Quality of Life
Authors: Jamilian Abdolreza , Kiaee Bita , Sanayei Shabnam , Khosravi Saeed , Perillo Letizia 
Published: May 2016

Objectives:Malocclusion, though not life-threatening, has vast impact on individual’s social interactions and self-esteem. Therefore, the aim of the current study was to assess whether orthodontic treatment of adolescents with malocclusion had any association with their oral health-related quality of life (OHRQoL).Methods:The subjects for this study were recruited at a state-funded university clinic. Data were collected from 100 participants aged 17 to 21 with moderate to severe malocclusion. Experimental group comprised of 50 subjects who were in the retention phase of their orthodontic treatment and the control group comprised of 50 untreated subjects. The shortened version of the Oral Health Impacts Profile (OHIP-14) as used to assess the subjects’ oral health-related impact. T-test, Kruskal-Wallis, and Mann Whitney tests were used to analyze the data andp-value was set atP< 0.05.Results:In general, oral health-related quality of life of all subjects significantly improved after orthodontic treatment. (p<0.001) Subjects with moderate malocclusion showed better improvement than severe malocclusion subjects. (P<0.001)Conclusion:This study showed that oral health-related quality of life improves with the treatment of malocclusion.
Predictors and Outcomes of Health–Related Quality of Life in Adults with CKD
Authors: Porter Anna C. , Lash James P. , Xie Dawei , Pan Qiang , DeLuca Jennifer , Kanthety Radhika , Kusek John W. , Lora Claudia M. , Nessel Lisa , Ricardo Ana C. , Wright Nunes Julie , Fischer Michael J. ,   the CRIC Study Investigators
Published: May 2016

Background and objectives
Low health–related quality of life is associated with increased mortality in patients with ESRD. However, little is known about demographic and clinical factors associated with health–related quality of life or its effect on outcomes in adults with CKD.

Design, settings, participants, & measurements
Data from 3837 adult participants with mild to severe CKD enrolled in the prospective observational Chronic Renal Insufficiency Cohort and Hispanic Chronic Renal Insufficiency Cohort Studies were analyzed. Health–related quality of life was assessed at baseline with the Kidney Disease Quality of Life-36 and its five subscales: mental component summary, physical component summary, burden of kidney disease (burden), effects of kidney disease (effects), and symptoms and problems of kidney disease (symptoms). Low health–related quality of life was defined as baseline score >1 SD below the mean. Using Cox proportional hazards analysis, the relationships between low health–related quality of life and the following outcomes were examined: (1) CKD progression (50% eGFR loss or incident ESRD), (2) incident cardiovascular events, and (3) all-cause death.

Results
Younger age, women, low education, diabetes, vascular disease, congestive heart failure, obesity, and lower eGFR were associated with low baseline health–related quality of life (P<0.05). During a median follow-up of 6.2 years, there were 1055 CKD progression events, 841 cardiovascular events, and 694 deaths. Significantly higher crude rates of CKD progression, incident cardiovascular events, and all-cause death were observed among participants with low health–related quality of life in all subscales (P<0.05). In fully adjusted models, low physical component summary, effects, and symptoms subscales were independently associated with a higher risk of incident cardiovascular events and death, whereas low mental component summary was independently associated with a higher risk of death (P<0.05). Low health–related quality of life was not associated with CKD progression.

Conclusions
Low health–related quality of life across several subscales was independently associated with a higher risk of incident cardiovascular events and death but not associated with CKD progression.
Neurocutaneous melanosis presented with giant congenital melanocytic nevi and primary intracranial melanoma
Authors: Shakya Anup , Huang Jinbai 
Published: May 2016

Neurocutaneous melanosis is a rare neurocutaneous syndrome defi ned by the presence of multiple and /or giant congenital cutaneous nevi and melanocytic deposits in the central nervous system with the infi ltration of leptomeninges. The major medical concern with giant congenital cutaneous nevi is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanosis. Neurological symptoms usually develop before 2 years of age, but rare in the second or third decades of life. A 24-year-old-man with giant hairy, pigmented nevus on his extremities, back, “bathing trunk” variety presented with onset of neurological symptoms only in second decade of life. Magnetic resonance imaging of brain revealed a large expansive lesion in the left parieto-occipital lobe with high intensity on T1- sequence, and was heterogeneous on T2-sequence with iso- and hyper intense areas. Post-surgical pathological diagnosis revealed characteristics of malignant melanoma. Our patient represents a rare association between neurocutaneous melanosis with giant congenital cutaneous nevi and development of primary intracranial melanoma with neurological symptoms appearing in adult life. The onset of neurological symptoms only in third decade of life in our patient illustrates the importance of recognizing the likelihood of neurocutaneous melanosis in children with giant congenital nevus with or without neurological symptoms.Journal of Kathmandu Medical College, Vol. 4(1) 2015, 29-33
Fatigue strength of hybrid welded 22MnB5 overlap joints
Authors: Kügler Helge , Möller Felix , Goecke Sven-Frithjof , Vollertsen Frank 
Published: May 2016

Abstract
In order to reduce the weight of automotive parts, lightweight materials like the press hardened AlSi coated high strength steel 22MnB5 is used. This steel enables a reduction of wall thicknesses and simultaneously ensures a high stiffness of the part, e. g., the B pillar. The usage of these steels requires suitable joining technologies. Therefore, a laser GMA hybrid welding process for fillet welds in overlap configuration was designed. This process provides high welding velocities and process tolerances against gaps and misalignments. In this case a single-mode fiber laser was used in order to reduce the thermal impact. Due to the fact that the laser focus spot has only a small diameter of 25 µm, a beam oscillation was used in order to distribute the laser energy over the melt pool width. This paper is focused on the cyclic load tests which were carried out and analyzed by the staircase method. The influences of laser power and oscillation width are dominating, whereas welding velocity and wire velocity have only a minor influence. By analyzing the failure location and crack propagation of specimens after the cyclic load test, the influence of the AlSi coating can be determined. Coating agglomerations at the fusion line of the melt pool are origins of crack initiation. This is attributed to the formation of brittle intermetallic phases.
Particularities of testing structured sheet metals in 3-point bending tests
Authors: Kazak Fedor , Schleuß Leander , Ossenbrink Ralf , Michailov Vesselin , Weiß Sabine 
Published: May 2016

Abstract
Thin sheet metals from deep drawing steel DC04 are very often used in the production of car body and case parts. Quality improvement of sheet metal components by new constructive solutions (structuring) as well as adapted joining technology is going on. Structured sheet metals differ from each other by their high bending stiffness. At the same time, they show certain anisotropy due to the structure. Therefore a typical testing method of structured semi-finished parts (single sheet metals, sandwiches) is the bending test. The literature review revealed that in many studies no special demands on tests of structured materials were made. This concerns particularly the structure arrangement, structure direction and structure location of the specimen relative to the mandrel position during bending tests, i. e., the direction of the fixed load relative to the structure. The aim of this study was to determine the influence of the test specification on flexural behavior. In the present paper, honeycomb-structured sheet metals were examined using 3-point bending tests. Bending stiffness and lightweight potential were calculated with respect to the location of load application and compared for different structure arrangements, directions and locations. The influence of the anisotropy on flexural behavior of the honeycomb-patterned sheet metals was moderate.
Investigation of glass transition kinetics in C60-doped carbazole-based photorefractive polyacrylates
Authors: Chen Shufan , Chen Baili , Huang Chuanqun , Luo Xuan , Fang Yu , Wu Weidong 
Published: May 2016

Abstract
This article describes the fabrication of C60-doped carbazole-based bi-functional photorefractive polyacrylates, the C60-doped concentrations are 0.0, 0.2, 0.5, 0.7 and 1.0 wt.-%, respectively. For these photorefractive polyacrylates, differential scanning calorimetric runs have been taken under nonisothermal conditions at different heating rates. The result indicates that the glass transition temperature Tg first increases and then decreases with increasing of C60 content. Tg of the same sample increases with increasing heating rate. The activation energy of glass transition (Eg) has been evaluated based on the Moynihan and Kissinger model. The results showed that both Eg values obtained from Kissinger's and Moynihan's relations are in good agreement.
Analysis of deformation induced martensite in AISI 316L stainless steel
Authors: Jagarinec Darko , Kirbiš Peter , Predan Jožef , Vuherer Tomaž , Gubeljak Nenad 
Published: May 2016

Abstract
Metastable austenite stainless steel AISI 316L is sensitive to cold deformation, where transformation from austenite to martensite occurred. The bending deformation as the formation process leads to tensile and compression troughout the thickness of the billet. Tensile testing of the specimen causes differences in the true stress-strain along the contraction neck prior to fracture as well. The aim of the paper is to find correlation between microhardness as brief inspection parameters and extension of martensitic transformation. The total equivalent plastic strain extend diagram obtained by numerical simulation of bending was compared with tensile true stress-strain diagram. Results show very good correlation between hardness, true strain and martesite content. Therefore, one can conclude that by hardness measurement, it is possible to measure the level of equivalent plastic strain until ultimate tensile stress as a linear correlation between hardness, true strain and martesite content.
Diffusible hydrogen content in submerged arc welds of a S960 type steel
Authors: Türker Mehmet 
Published: May 2016

Abstract
Hydrogen induced damage is a dangerous phenomenon affecting the weld quality with regard to construction service life even without visible indication. The determination of diffusible hydrogen in weld metal has been standardized at an international level in ISO 3690:2012. This international standard specifies the sampling and analytical procedure for the determination of diffusible hydrogen in martensitic, bainitic and ferritic steel weld metal which arises from the welding of such steels using arc welding processes with filler metal. In this study, S960QL steel is extensively used in the heavy transport, lifting and mining industry, where mobile or fixed structures have to carry high loads – often in safety critical situations. In order to sustain extreme characteristics of these high strength low alloy steels, it is a must to reduce the manufacturing defects. In the investigations presented in this paper, the influence of arc length on the weld metal hydrogen concentration was studied according to the ISO DIS 3690 in S960QL type steel with submerged arc welding. Measurement of the diffusible hydrogen was carried out by means of carrier gas hot extraction method. The weld seams with different arc length have similar chemical compositions. Maximum hardness values in the range of 410–425 HV1 were measured in the HAZ on both vertical and horizontal rows in welded structure with two mm wire diameter due to recrystallization condition. For four mm wire diameter, the hardness decreasing which is depending on the grain coarsening in the welded samples with two mm was not occurred in the weld seam-HAZ interface. The larger weld pool and the long arc length increased possibility of hydrogen pick-up and absorbing. Because of this reason, the diffusible hydrogen contents in the welded structure increased in accordance with the arc length.
Non Random Distribution of DMD Deletion Breakpoints and Implication of Double Strand Breaks Repair and Replication Error Repair Mechanisms
Authors: Marey Isabelle , Ben Yaou Rabah , Deburgrave Nathalie , Vasson Aurélie , Nectoux Juliette , Leturcq France , Eymard Bruno , Laforet Pascal , Behin Anthony , Stojkovic Tanya , Mayer Michèle , Tiffreau Vincent , Desguerre Isabelle , Boyer François Constant , Nadaj-Pakleza Aleksandra , Ferrer Xavier , Wahbi Karim , Becane Henri-Marc , Claustres Mireille , Chelly Jamel , Cossee Mireille 
Published: May 2016

Background: Dystrophinopathies are mostly caused by copy number variations, especially deletions, in the dystrophin gene ( DMD). Despite the large size of the gene, deletions do not occur randomly but mainly in two hot spots, the main one involving exons 45 to 55. The underlying mechanisms are complex and implicate two main mechanisms: Non-homologous end joining (NHEJ) and micro-homology mediated replication-dependent recombination (MMRDR). Objective: Our goals were to assess the distribution of intronic breakpoints (BPs) in the genomic sequence of the main hot spot of deletions within DMD gene and to search for specific sequences at or near to BPs that might promote BP occurrence or be associated with DNA break repair. Methods: Using comparative genomic hybridization microarray, 57 deletions within the intron 44 to 55 region were mapped. Moreover, 21 junction fragments were sequenced to search for specific sequences. Results: Non-randomly distributed BPs were found in introns 44, 47, 48, 49 and 53 and 50% of BPs clustered within genomic regions of less than 700bp. Repeated elements (REs), known to promote gene rearrangement via several mechanisms, were present in the vicinity of 90% of clustered BPs and less frequently (72%) close to scattered BPs, illustrating the important role of such elements in the occurrence of DMD deletions. Palindromic and TTTAAA sequences, which also promote DNA instability, were identified at fragment junctions in 20% and 5% of cases, respectively. Micro-homologies (76%) and insertions or deletions of small sequences were frequently found at BP junctions. Conclusions: Our results illustrate, in a large series of patients, the important role of RE and other genomic features in DNA breaks, and the involvement of different mechanisms in DMD gene deletions: Mainly replication error repair mechanisms, but also NHEJ and potentially aberrant firing of replication origins. A combination of these mechanisms may also be possible.
Targeted Re-Sequencing Emulsion PCR Panel for Myopathies: Results in 94 Cases
Authors: Punetha Jaya , Kesari Akanchha , Uapinyoying Prech , Giri Mamta , Clarke Nigel F. , Waddell Leigh B. , North Kathryn N. , Ghaoui Roula , O’Grady Gina L. , Oates Emily C. , Sandaradura Sarah A. , Bönnemann Carsten G. , Donkervoort Sandra , Plotz Paul H. , Smith Edward C. , Tesi-Rocha Carolina , Bertorini Tulio E. , Tarnopolsky Mark A. , Reitter Bernd , Hausmanowa-Petrusewicz Irena , Hoffman Eric P. 
Published: May 2016

Background: Molecular diagnostics in the genetic myopathies often requires testing of the largest and most complex transcript units in the human genome ( DMD, TTN, NEB). Iteratively targeting single genes for sequencing has traditionally entailed high costs and long turnaround times. Exome sequencing has begun to supplant single targeted genes, but there are concerns regarding coverage and needed depth of the very large and complex genes that frequently cause myopathies. Objective: To evaluate efficiency of next-generation sequencing technologies to provide molecular diagnostics for patients with previously undiagnosed myopathies. Methods: We tested a targeted re-sequencing approach, using a 45 gene emulsion PCR myopathy panel, with subsequent sequencing on the Illumina platform in 94 undiagnosed patients. We compared the targeted re-sequencing approach to exome sequencing for 10 of these patients studied. Results: We detected likely pathogenic mutations in 33 out of 94 patients with a molecular diagnostic rate of approximately 35%. The remaining patients showed variants of unknown significance (35/94 patients) or no mutations detected in the 45 genes tested (26/94 patients). Mutation detection rates for targeted re-sequencing vs. whole exome were similar in both methods; however exome sequencing showed better distribution of reads and fewer exon dropouts. Conclusions: Given that costs of highly parallel re-sequencing and whole exome sequencing are similar, and that exome sequencing now takes considerably less laboratory processing time than targeted re-sequencing, we recommend exome sequencing as the standard approach for molecular diagnostics of myopathies.
A NEW CONCEPT FOR SPECTROPHOTOMETRY OF EXOPLANETS WITH SPACE-BORNE TELESCOPES
Authors: Matsuo Taro , Itoh Satoshi , Shibai Hiroshi , Sumi Takahiro , Yamamuro Tomoyasu 
Published: May 2016

ABSTRACT
We propose a new concept for the spectral characterization of transiting exoplanets with future space-based telescopes. This concept, called densified pupil spectroscopy, allows us to perform high, stable spectrophotometry against telescope pointing jitter and deformation of the primary mirror. This densified pupil spectrometer comprises the following three roles: division of a pupil into a number of sub-pupils, densification of each sub-pupil, and acquisition of the spectrum of each sub-pupil with a conventional spectrometer. Focusing on the fact that the divided and densified sub-pupil can be treated as a point source, we discovered that a simplified spectrometer allows us to acquire the spectra of the densified sub-pupils on the detector plane−an optical conjugate with the primary mirror−by putting the divided and densified sub-pupils on the entrance slit of the spectrometer. The acquired multiple spectra are not principally moved on the detector against low-order aberrations such as the telescope pointing jitter and any deformation of the primary mirror. The reliability of the observation result is also increased by statistically treating them. Our numerical calculations show that because this method suppresses the instrumental systematic errors down to 10 ppm under telescopes with modest pointing accuracy, next generation space telescopes with more than 2.5 m diameter potentially provide opportunities to characterize temperate super-Earths around nearby late-type stars through the transmission spectroscopy and secondary eclipse.
Produire un espace hybride de coopération
Authors: Trupia Dilara Vanessa 
Published: May 2016

Phénomène récent, l’essor des espaces de coworking fait de plus en plus l’objet de travaux sociologiques qui investissent ces nouveaux terrains, notamment dans le contexte général des rapports dialectiques entre le développement de nouvelles formes de structuration économique fondées sur la connaissance et la transformation des modes traditionnels d’organisation du travail. Cependant, peu de travaux décrivent ce qu’il se passe concrètement au sein de ces espaces appréhendés principalement à travers leur public, les coworkers, et caractérisés par des liens de coopération faibles. C’est ce que cet article, basé sur une ethnographie réalisée au sein d’un espace de travail coopératif, appelé « La Cantine » et géré par l’association d’entreprises « Silicon Sentier », tente de décrire : les mécanismes interactionnels à travers lesquels l’espace physique ainsi que le « travail d’articulation » des permanents de l’association produisent différentes formes de « débordements » pour in fine, organiser la coopération entre différents acteurs, grandes organisations et indépendants.
Le perceptif en psychosomatique Discussion du texte de Guy Lavallée
Authors: Deburge Anne 
Published: May 2016

Les interrogations de l’auteure portent sur la généralisation du modèle présenté par Guy Lavallée sur « l’enveloppe visuelle du moi généralisée » à la Journée IPSO de juin 2015. À partir de la clinique psychosomatique et de celle du traumatisme, c’est la question de la psychisation de la perception qui est posée. L’observation d’un patient souffrant d’une atteinte corporelle objet d’un déni, puis sa levée sous l’effet du processus de la cure, illustre notre propos. La notion de « moi inconscient » est intéressante pour aborder la compréhension du fonctionnement de ce type de patient.
Perception et relaxation analytique : une pause créatrice
Authors: Dechaud-Ferbus Monique 
Published: May 2016

En hommage à Marie-Lise Roux et à ses travaux sur la médiation sensori-perceptivo-motrice, l’auteur décrit le processus de la cure de psychothérapie psychanalytique corporelle (PPC) d’une patiente « psychosomatique ». Une « pause créatrice » permet la réorganisation du masochisme érogène grâce à l’investissement conjoint patient/thérapeute des états du corps. Déplaisir ou douleur s’intriquent avec le narcissisme primaire grâce à l’objet, fournissant les bases d’une évolution vers un équilibre psychosomatique.