bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geostatistical methods for mapping groundwater nitrate concentrations: a case study of the El-Oued region
Authors: Abdelmonem Miloudi , Nadjet Zair , Badra Attoui , Abderrahmane Khechekhouche , Boualem Remini 
Published: September 2024

ABSTRACT

Geostatistical modeling is a powerful tool for improving the characterization, management, and prediction of decision-making processes. The Wilaya of El-Oued is considered the backbone of agriculture in Algeria, covering 40% of the total cultivated area in the country. This makes it one of the regions with the highest consumption of agricultural fertilizers to meet the aspirations of local authorities in this field. Additionally, it has experienced significant population growth in recent years, coupled with a weak sewage network, which could lead to the direct contamination of groundwater and the region's natural resources. This study aims to test various deterministic interpolation methods, such as the inverse distance weighting (IDW) method, the radial basis function (RBF), and the geostatistical methodology (point kriging), for mapping nitrates in 113 wells in the El-Oued aquifer. We utilized Surfer 20 for this purpose. Given the significant differences in estimates based on the methods used, it is appropriate to evaluate the spatial distribution maps of nitrates obtained by comparing their predictive qualities through the calculation of the mean estimation error. The results indicate the superiority of the point kriging technique compared with deterministic estimates, with R2 estimation errors of about 0.067.
ÍNDICE CPOD E FATORES ASSOCIADOS DOS MORADORES DE UM MUNICÍPIO DE PEQUENO PORTE NO NORDESTE BRASILEIRO
Authors: Ribeiro Rafael Bezerra , Oliveira Ana Luiza , Nobre Leonardo Thiago Duarte Barreto , Santos Sarah Betânia Santos de , Silva Tiago Lameque de Sousa e , Almeida Maria Luiza Braz de , Lucena Eudes Euler de Souza 
Published: September 2024

Introdução: A atenção à Saúde Bucal no Brasil foi qualificada a partir da Política Nacional de Saúde Bucal (PNSB), através do Sistema Único de Saúde (SUS), fomentando ações de promoção, prevenção e recuperação da saúde bucal da população. A avaliação da prevalência de cárie dentária em determinada comunidade, para Estudos Epidemiológicos em Saúde Bucal, pode ser realizada por meio do índice CPOD, que fornece a quantidade média de dentes cariados, perdidos e obturados. Objetivo: O presente trabalho objetivou aferir o índice CPOD dos moradores de uma área coberta pela Equipe de Saúde Bucal (ESB) de um município de pequeno porte, caracterizar seu perfil socioeconômico, verificar seu comportamento quanto ao uso de serviços odontológicos e identificar fatores associados ao índice. Metodologia: Foi realizado um estudo de prevalência do tipo exploratório e descritivo com abordagem quantitativa em residentes de um município de pequeno porte com cobertura pela Equipe de Saúde Bucal. Foi utilizado um questionário de caracterização individual abordando identificação socioeconômica e comportamento relacionado à saúde bucal. Resultados: Na análise do CPOD, a média de dentes perdidos (5,44) foi maior que a dos dentes obturados (4,31) e cariados (1,34). O desfecho CPOD foi associado positivamente com a idade e a necessidade do uso de prótese dentária. Conclusões: Observou-se uma média mais alta de dentes perdidos, seguida por dentes obturados, e uma média menor de dentes cariados. Verificamos que o índice CPOD individual foi mais elevado em pessoas com mais de 34 anos e naqueles que necessitavam de próteses dentárias.
Palavras-Chave: Saúde Bucal; Índice CPO; Estratégia Saúde da Família.
Studies on the Preparation of a Microemulsion Formulation of Matricaria Recutita Essential Oil and the Treatment of 2,4-Dinitro-Chlorobenzene-
Induced Eczema in Mice by Inhibiting Inflammation
Authors: Wang Dongxu , Wang Wenfei , Zhang Qibin , Liu Chang , Li Xuefei , Zuo Kangrui , Xie Yundong , Zhang Xiaofei 
Published: September 2024

Background:
Eczema, an inflammatory skin disease causing intense itching, is a function
of a range of internal and external factors, impacting individuals of all ages and leading to economic
loss. Inflammation is the most important manifestation of eczema, and Matricaria recutita essential oil
(MREO) extracted from Matricaria recutita possesses excellent antibacterial and anti-inflammatory
properties.

Methods:
In this study, Matricaria recutita microemulsions were prepared by the trans-phase emulsification
method and their stability was determined by evaluating the relevant indexes. Establishment
of 2,4-dinitro-chlorobenzene-induced AD model in mice. Detection of serum indexes of IL-6, IL-17,
and TNF-α, and on pathological tissue sections, the HE staining, toluidine blue staining, immunohistochemistry,
and observation were performed.

Results:
The study obtained optimal conditions for the preparation of microemulsion formulations of
Matricaria recutita. Through quality evaluation, it was found that the microemulsion increased stability,
reduced irritation, and retained anti-inflammatory activity and therapeutic effects on eczema
compared to Matricaria recutita essential oil (MREO). Studies have demonstrated that microemulsion
formulations of Matricaria recutita and Matricaria recutita significantly down regulate the proinflammatory
factors TNF-α, IL-17, and IL-6. It was shown by hematoxylin-eosin (HE) staining that
both Matricaria recutita essential oil (MREO) and Matricaria recutita microemulsion (MRME) improved
the inflammatory status of eczematous skin tissues in mice. The number of mast cells expressed
in the tissues was decreased in the surface-treated group, as shown by toluidine blue staining.
Additionally, the number of mast cells expressed in the tissues in the surface-treated group was reduced,
as demonstrated by immunohistochemistry. Furthermore, immunohistochemistry revealed that
MREO and MRME have immunomodulatory effects on the tissues.

Conclusion:
The study showed that microemulsion formulations of Matricaria recutita may serve as a
novel remedy for eczema.
CNDP1 Suppresses the Malignant Behavior of Hepatoma Cell via Restricting PI3K-AKT-mTOR Activation
Authors: Du Youwen , Pan Linxin , Zhang Wenchen , Wei Shuangbiao , Fan Xu , Zhang Na , Wei Pengjun , Chen Xiaoqian , Qiao Zhi , Xie Li 
Published: September 2024

Introduction:
Hepatocellular carcinoma (HCC) is a global health problem with increasing morbidity and mortality, and exploring the diagnosis and treatment of HCC at the gene level has be-come a research hotspot in recent years. As the rate-limiting enzyme of carnosine hydrolysis, CNDP1 participates in the progress of many diseases, but its function in HCC has not been fully elucidated.

Methods:
This study firstly screened differentially expressed genes from the biochip related to HCC by bioinformatic analysis, and CNDP1 was finally selected for in-depth study. Then the bioinformatics analysis results were validated by detecting the expression of CNDP1 in human HCC samples and he-patoma cell lines. Furthermore, the effect of CNDP1 on the malignant behavior of hepatoma cell lines were assessed using MTT colorimetric assay, EdU staining assay, colony formation, wound-healing assay and transwell, and the molecular mechanism was also preliminarily explored.

Results:
This study found that CNDP1 expression was decreased significantly in human HCC tissues and cell lines, and its overexpression could significantly suppress cell proliferation, migration and in-vasion of hepatoma cell lines. Mechanistically the GeneMANIA database predicted that CNDP1 could interact with various proteins involved in regulating PI3K-AKT-mTOR signaling pathway. Further-more, this study showed that CNDP1 overexpression could effectively inhibit the activation of PI3K-AKT-mTOR signaling pathways, more significantly, inhibition of PI3K-AKT-mTOR signaling path-way could disrupt the anti-cancer effect of CNDP1 on HCC.

Conclusion:
This study confirm that CNDP1 expression is decreased significantly in HCC, and has potential anti-cancer activity, this discovery provides a cytological basis for further understanding the biological function of CNDP1 and diagnosis and gene therapy of HCC in the future.
Efficacy of Adjunctive Local Antimicrobials to Non-Surgical Periodontal Therapy in Pocket Reduction and Glycemic Control of Patients with Type 2 Diabetes: A Network Meta-Analysis
Authors: de Oliveira Domitilla Marchiori Sant’Anna Leal , de Souza Ana Luiza Magalhães , da Rocha Nogueira Filho Getulio , Martins-Pfeifer Carolina Castro , Stefani Cristine Miron 
Published: September 2024

Objective:
This network meta-analysis [NMA] investigated the efficacy of adjunctive
use of subgingivally delivered antimicrobials to non-surgical periodontal therapy [NSPT] in the
glycemic control and periodontal pocket depth (PPD) reduction in patients with type 2 diabetes
(T2D).

Methods:
Seven databases, grey literature, and registry platforms were searched up to February
2024 to identify randomized clinical trials (RCT) fulfilling the eligibility criteria. The risk of bias
was assessed through Cochrane’s tool (RoB 2). Two frequentist NMA were performed using a
random-effects model to calculate mean differences (MD) as an effect measure and to
quantitatively evaluate the glycated hemoglobin (HbA1c) and PPD. The certainty of evidence
was assessed through the GRADE approach in a partially contextualized framework for
interpreting results. Ten RCTs were included.

Results:
In total, 261 patients were treated with eight different local antimicrobials adjuvants to
NSPT (azithromycin gel, clarithromycin gel, tetracycline fiber or ointment, chlorhexidine gel,
doxycycline nanospheres, minocycline gel, and satranidazole gel), while 249 patients received
NSPT alone or associated to placebo. Considering PPD reduction (8 included studies), the best
results were found after six months for satranidazole gel (MD -2.64mm; 95%CI -3.56, -1.72;
moderate evidence certainty). For HbA1c control (7 included studies), doxycycline gel (MD -
0.80%; 95%CI -1.70, 0.10), chlorhexidine gel (MD -0.68%; 95%CI -1.34, -0.02), and
tetracycline fiber (MD -0.62%; 95%CI -0.85, -0.39) showed promising results after three months
(low evidence certainty).

Conclusion:
The adjunctive use of satranidazole gel probably reduces PPD after a 6-month
follow-up, while doxycycline gel, chlorhexidine gel, and tetracycline fiber may decrease HbA1c
values in patients with T2D and periodontitis treated with NSPT after a 3-month follow up.
Investigating, Characterizing, and Optimizing Various Modified Surfaces of Titanium Dental Implants using Anodization and Physical Patterns
Authors: Garshasbi Hamid Reza , Askari Esfandyar , Kashani Ghazal Kadkhodaie , Naghib Seyed Morteza , Tilebon Seyyed Mohamad Sadati , Emamian Seyed Amirhossein , Ramezanpour Hosseinali , Eslami Hossein , Ansari Mojtaba , Salehi Malihe 
Published: September 2024

Background:
Implants made of titanium are significant in the orthopedic and dental
fields. Strong osteointegration can only be achieved by surface modification technologies. The benefits
of titanium are numerous, but its inert state prevents it from integrating with human cell's biologically.
The titanium implant’s surface is crucial for osseointegration and implant success; hence this
is necessary. How to apply osteoconductive coatings or increase the surface roughness of titanium
dental implants has been investigated. Surface treatments include grit blasting, acid etching, anodizing,
and coatings with calcium phosphate. Clinical efficacy has been demonstrated for most marketed
surfaces (>95%). The exact involvement of surface topography and chemical reactions in early
dental implant osseointegration is still unclear.

Methods:
Sixteen implant samples were made with different parameters. Each one has 5 parameters,
including Sandblast Pressure (SP), Sandblast Cycle (SC), Anodizing Time (AT), Anodizing Voltage
(AV), and Etching Time (ET). Physical and chemical characterization was used to identify optimized
samples. SEM, EDS, XRD, Biodegradation, Contact Angle, Microhardness, MTT, Real-Time PCR,
and Antibacterial tests were taken from the samples.

Results:
Different surface treatments showed that all surfaces were roughened and micro-nano structures
had been shaped. The microhardness of some samples increased during surface treatment.
Sample number 14 has potentially antibacterial activities.

Conclusion:
Future dental implants may be able to detect tissue formation and cellular attachment,
which could facilitate medication release. The future of flexible, multipurpose dental implants lies in
additive manufacturing, biosensing, and triggered drug-release technologies.
A Simple and Novel Technique for the Determination of Rhodamine B in Cosmetics Based on Dispersive Surfactant Micelle-mediated Extraction
and Image Colorimetric Analysis
Authors: Khoshmaram Leila , H. Fatemeh Zakeran 
Published: September 2024

Aims:
The primary objective of this study was to develop a simple, selective, sensitive,
and rapid method for the determination of trace levels of Rhodamine B in different cosmetic items.

Background:
At present, synthetic dyes in various colors are essential in cosmetic products, not only
for adding pleasant scents, but also for enhancing their appeal and restoring natural colors. Rhodamine
B, a pink synthetic azo dye, is widely used in the cosmetic industry. It poses risks if ingested by
humans and animals, causing skin, eye, and respiratory irritation. Scientific studies have shown that
it has carcinogenic, reproductive, developmental, neurotoxic, and chronic toxic effects on both humans
and animals. Therefore, the improvement of precise and fast measurement techniques for detecting
Rhodamine B in different sample types is crucial.

Objective:
The objective of this study was to find a fast, accurate, and sensitive method for the determination
of trace levels of Rhodamine B in different cosmetic items.

Methods:
The technique used has been based on Dispersive Surfactant Micelle-mediated Extraction
(DSME) combined with digital image analysis.

Results:
The optimized method yielded a linear calibration graph ranging from 25 to 300 μg L-1,
with a correlation coefficient of 0.9975 and the Limit of Detection (LOD) of 6.7 μg L-1. The proposed
method was used to measure Rhodamine B in lipstick and nail polish samples, resulting in
satisfactory recoveries ranging from 97.8 to 107.2%.

Conclusion:
DSME could remove the necessity of high temperature, hazardous organic solvents, and
anionic surfactants in Cloud Point Extraction (CPE) and Catanionic Surfactants-based Coacervation
Extraction (CSCE). Additionally, experiments have shown the results from digital image analysis to
be in line with those from a commercial UV-Vis spectrophotometer and a spectrofluorometer. The
authors believe that utilizing DSME image analysis could be a beneficial alternative to the analytical
analysis of other colored species in routine analysis.
Immunomodulatory Roles of IL-15 in Immune Cells and its Potential for Cancer Immunotherapy
Authors: Liu Youhan , Ma Wen , Tian Xuewen , Wang Qinglu , Lu Xin , Luo Ying , Xu Jun 
Published: September 2024

:
Interleukin-15 (IL-15) was identified in 1994 as a T-cell growth factor with the capability to mimic the
functions of IL-2. IL-15 engages with the IL-15Rα subunit expressed on the surface of antigen-presenting cells
(APCs) and, through a trans-presentation mechanism, activates the IL-2/IL-15Rβγ complex receptor on the surface
of natural killer (NK) cells and CD8+ T cells. This interaction initiates a cascade of downstream signaling
pathways, playing a pivotal role in the activation, proliferation, and anti-apoptotic processes in NK cells, CD8+ T
cells, and B cells. It provides a substantial theoretical foundation and potential therapeutic targets for tumor immunotherapy.
Whether through active or passive immunotherapeutic strategies, IL-15 has emerged as a critical
molecule for stimulating anti-tumor cell proliferation.
In Vitro Anti-Dandruff Activity of Karnasphotha (Cardiospermum helicacabum Linn.) against Malassezia furfur
Authors: Sarojini D Byadigi  , Ashwini Kochari  
Published: September 2024

Background: Dandruff is a common skin condition that mainly affects the scalp. Almost half of the population at the pre-pubertal age and of any gender and ethnicity will be affected. It was discovered that the responsible agent is a scalp specific fungus, Malassezia globosa. Karnasphotha (Cardiospermum helicacabum Linn.) commonly known as Balloon vine from Sapindaceae family is traditionally used for dandruff. So here an attempt is made to study the in vitro efficacy of Karnasphota (Cardiospermum helicacabum Linn.) decoction against dandruff. Aims and Objectives: In vitro Antidandruff activity of Karnasphota Mula and Beeja by Agar cup method and Biocidal activity. Methodology: In vitro Antidandruff activity of Karnasphota (Cardiospermum helicacabum Linn.) Bija and Mula Kwatha against dandruff by – Agar cup method and Biocidal activity. Result: The Karnasphotha Moola showed good antidandruff activity against Malassezia furfur in different concentrations. Whereas Karnasphotha Beeja showed no antidandruff activity against Malassezia furfur in any concentrations. Conclusion: The Karnasphotha Moola is having significant Antidandruff properties.
ANALISIS PENGARUH LUAS LAHAN, BESARNYA MODAL, TINGKAT PENDIDIKAN, DAN JUMLAH TENAGA KERJA TERHADAP PENDAPATAN USAHA TANI KOPI KECAMATAN DAMPIT
Authors: Arista Amanda Putri  , Bahtiar Fitanto  
Published: September 2024

This study aims to find out how the variables of land area, amount of capital, level of education and number of labor affect the income of coffee farmers in Dampit District. In this study using descriptive quantitative research methods with classic assumptions test and multiple linear regression analysis . The data used in this study are primary data from questionnaires and interviews with 86 respondents. This study found that the variables of land area, amount of capital and level of education partially had an influence on the income of coffee farmers in Dampit. Meanwhile, the variable number of labor has no effect on the income of coffee farmers in Dampit. From the results of this study, suggested for coffee farmers in Dampit District to further increase productivity both from physical capital or human resources in order to achieve results in the form of income effectively and efficiently.
User Views on Online Sexual Health Symptom Checker Tool: Qualitative Research
Authors: King Alicia Jean , Bilardi Jade Elissa , Towns Janet Mary , Maddaford Kate , Fairley Christopher Kincaid , Chow Eric P F , Phillips Tiffany Renee 
Published: September 2024

Background
Delayed diagnosis and treatment of sexually transmitted infections (STIs) contributes to poorer health outcomes and onward transmission to sexual partners. Access to best-practice sexual health care may be limited by barriers such as cost, distance to care providers, sexual stigma, and trust in health care providers. Online assessments of risk offer a novel means of supporting access to evidence-based sexual health information, testing, and treatment by providing more individualized sexual health information based on user inputs.

Objective
This developmental evaluation aims to find potential users’ views and experiences in relation to an online assessment of risk, called iSpySTI (Melbourne Sexual Health Center), including the likely impacts of use.

Methods
Individuals presenting with urogenital symptoms to a specialist sexual health clinic were given the opportunity to trial a web-based, Bayesian-powered tool that provides a list of 2 to 4 potential causes of their symptoms based on inputs of known STI risk factors and symptoms. Those who tried the tool were invited to participate in a once-off, semistructured research interview. Descriptive, action, and emotion coding informed the comparative analysis of individual cases.

Results
Findings from interviews with 14 people who had used the iSpySTI tool support the superiority of the online assessment of STI risk compared to existing sources of sexual health information (eg, internet search engines) in providing trusted and probabilistic information to users. Additionally, potential users reported benefits to their emotional well-being in the intervening period between noticing symptoms and being able to access care. Differences in current and imagined urgency of health care seeking and emotional impacts were found based on clinical diagnosis (eg, non-STI, curable and incurable but treatable STIs) and whether participants were born in Australia or elsewhere.

Conclusions
Online assessments of risk provide users experiencing urogenital symptoms with more individualized and evidence-based health information that can improve their health care–seeking and provide reassurance in the period before they can access care.
Constructing a Hospital Department Development–Level Assessment Model: Machine Learning and Expert Consultation Approach in Complex Hospital Data Environments
Authors: Liu Jingkun , Tai Jiaojiao , Han Junying , Zhang Meng , Li Yang , Yang Hongjuan , Yan Ziqiang 
Published: September 2024

Background
Every hospital manager aims to build harmonious, mutually beneficial, and steady-state departments. Therefore, it is important to explore a hospital department development assessment model based on objective hospital data.

Objective
This study aims to use a novel machine learning algorithm to identify key evaluation indexes for hospital departments, offering insights for strategic planning and resource allocation in hospital management.

Methods
Data related to the development of a hospital department over the past 3 years were extracted from various hospital information systems. The resulting data set was mined using neural machine algorithms to assess the possible role of hospital departments in the development of a hospital. A questionnaire was used to consult senior experts familiar with the hospital to assess the actual work in each hospital department and the impact of each department’s development on overall hospital discipline. We used the results from this questionnaire to verify the accuracy of the departmental risk scores calculated by the machine learning algorithm.

Results
Deep machine learning was performed and modeled on the hospital system training data set. The model successfully leveraged the hospital’s training data set to learn, predict, and evaluate the working and development of hospital departments. A comparison of the questionnaire results with the risk ranking set from the departments machine learning algorithm using the cosine similarity algorithm and Pearson correlation analysis showed a good match. This indicates that the department development assessment model and risk score based on the objective data of hospital systems are relatively accurate and objective.

Conclusions
This study demonstrated that our machine learning algorithm provides an accurate and objective assessment model for hospital department development. The strong alignment of the model's risk assessments with expert opinions, validated through statistical analysis, highlights its reliability and potential to guide strategic hospital management decisions.
Достижения и перспективы фотоэлектроники на XXVII Международной конференции в НПО «Орион»
Authors: Наумов А.В. 
Published: September 2024

29–31 мая 2024 года в Москве состоялась XXVII Международная научно-техническая
конференция по фотоэлектронике и приборам ночного видения. Конференция была
организована Государственным научным центром Российской Федерации АО «НПО «Орион» (ГНЦ РФ НПО «Орион») при поддержке Минпромторга России, Минобрнауки России, Российского научного фонда, Ассоциации государственных научных центров «Наука».