bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moderate-to-severe atopic dermatitis patients show increases in serum C-reactive protein levels, correlating with skin disease activity
Authors: Vekaria Anjali S. , Brunner Patrick M. , Aleisa Ahmad I. , Bonomo Lauren , Lebwohl Mark G. , Israel Ariel , Guttman-Yassky Emma 
Published: October 2017

Background: Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is evolving as a systemic disease, and associated systemic inflammation is possibly linked to increases in cardiovascular disease. Methods: We assessed levels of the inflammatory marker CRP in 59 patients with moderate-to-severe AD compared to matched healthy controls, and to determine correlation with skin disease severity. Clinical severity was measured using SCORing of Atopic Dermatitis (SCORAD) and body surface area (BSA). Control subjects (n=118), matched by age, gender, smoking status and ethnicity, were obtained from the National Health and Nutrition Survey (NHANES). Results: AD patients had significantly increased serum CRP levels compared to controls (0.7±1.0 vs. 0.4±0.7mg/dl; p=0.001), and 52.5% of them showed CRP levels >0.3mg/dl, predicting high cardiovascular risk. CRP levels were significantly correlated with both SCORAD (r=0.427, p=0.0008) and BSA (r=0.407, p=0.0015). IgE levels in AD were highly elevated (median 2903U/ml, IQR [234,10655]), but only weakly correlated with SCORAD (r=0.282, p=0.0427) and BSA (r=0.382, p=0.0052), but not with CRP levels. AD patients also showed increased LDH levels, but without significant correlations with disease severity (SCORAD, BSA) or CRP. Conclusions: Our study strongly supports CRP as a marker for disease severity in moderate-to-severe AD patients, further demonstrating its chronic systemic nature.
Prenatal maternal plasma DNA screening for cystic fibrosis: A computer modelling study of screening performance
Authors: Old Robert W. , Bestwick Jonathan P. , Wald Nicholas J. 
Published: October 2017

Background: Prenatal cystic fibrosis (CF) screening is currently based on determining the carrier status of both parents. We propose a new method based only on the analysis of DNA in maternal plasma. Methods: The method relies on the quantitative amplification of the CF gene to determine the percentage of DNA fragments in maternal plasma at targeted CF mutation sites that carry a CF mutation. Computer modelling was carried out to estimate the distributions of these percentages in pregnancies with and without a fetus affected with CF. This was done according to the number of DNA fragments counted and fetal fraction, using the 23 CF mutations recommended by the American College of Medical Genetics for parental carrier testing. Results: The estimated detection rate (sensitivity) is 70% (100% of those detected using the 23 mutations), the false-positive rate 0.002%, and the odds of being affected given a positive screening result 14:1, compared with 70%, 0.12%, and 1:3, respectively, with current prenatal screening based on parental carrier testing. Conclusions: Compared with current screening practice based on parental carrier testing, the proposed method would substantially reduce the number of invasive diagnostic procedures (amniocentesis or chorionic villus sampling) without reducing the CF detection rate. The expected advantages of the proposed method justify carrying out the necessary test development for use in a clinical validation study.
Predictive value of early postoperative IOP and bleb morphology in Mitomycin-C augmented trabeculectomy
Authors: Esfandiari Hamed , Pakravan Mohammad , Loewen Nils A. , Yaseri Mehdi 
Published: October 2017

Background: Our aim was to determine the predictive value of postoperative bleb morphological features and intraocular pressure (IOP) on the success rate of trabeculectomy. Methods: In this prospective interventional case series, we analyzed for one year 80 consecutive primary open angle glaucoma patients who underwent mitomycin-augmented trabeculectomy. Bleb morphology was scored using the Indiana bleb appearance grading scale (IBAGS). Success was defined as IOP ≤15 mmHg with or without medications at 12 months. We tested for IOP and bleb morphological differences between groups, applied a multivariable regression analysis and determined the area under the receiver operating characteristic curve (AUC). Results: Age and gender were equally distributed (62.3±13.1 years, P=0.911). IOP of patients with a successful outcome did not differ from unsuccessful ones on day 1, 7 and 30 (all P≥0.2). The AUC of IOP at day 1, day 7 and 30 for predicting a successful outcome was 0.355, 0.452, and 0.80, respectively. The AUC for bleb morphology parameters, bleb height, extension, and vascularization, on day 14 were 0.368, 0.408, and 0.549, respectively. Values for day 30 were 0.428, 0.563, and 0.654. IOP change from day 1 to day 30 was a good predictor of failure (AUC=0.838, 95% CI: 0.704 to 0.971) with a change of more than 3 mmHg predicting failure with a sensitivity of 82.5% (95% CI: 68 to 91%) and a specificity of 87.5% (95% CI: 53 to 98%). Conclusions: The postoperative IOP on day 30 had a fair to good accuracy while the bleb features failed to predict a successful outcome. An IOP increase by as little as more than 3 mmHg during the first 30 days was a good predictor of failure.
Reconstruction of Bremsstrahlung Spectrum of Medical Electron Linear Accelerators from Deep Dose Distributions in Water Phantom
Authors: Климанов В. , Klimanov V. , Галяутдинова Ж. , Galyautdinova Zh. , Могиленец Н. , Mogilenec N. , Смирнов В. , Smirnov V. 
Published: October 2017

Purpose: Development of the bremsstrahlung spectrum reconstruction method of medical electron linear accelerators (ELA) with different field sizes on the base of the deep dose distributions in a water phantom and determination of photon spectra for Varian Trilogy accelerator 6 MV.
Material and methods: The proposed methodology is based on the use of dose kernels algorithm of point monoenergetic monodirectional source (pencil beam (PB)) for the deep dose distribution calculation, created different cross-section beams of in a water phantom, and experimental measurements of these distributions. For solving the inverse problem is applied Toolbox routines 'ptimtool knowing mathematical package MATLAB to solve.
Results: Bremsstrahlung energy spectrum generated medical accelerator Varian Triology with different sizes of square fields from 3×3 up to 40×40 cm and average energy photons, depending on the size of the fields were received. Dose kernels for a set of defined energies PB were calculated. Depth dose distribution in a water phantom, calculated using the obtained spectra and dose kernels agree well with measurement dose distributions.
Conclusion: The proposed technique reconstruction of bremsstrahlung spectrum of electron linear accelerator is adequate. Average energy spectra of	bremsstrahlung photons for Varian Trilogy Accelerator in regime 6 MV varies from 1.71 to 1.43 MeV depending on the field size.
COPYRIGHT PRINCIPLES OF CONSTRUCTION THE EDUCATIONAL SYSTEM OF THE GROUP
Authors: Тюрина Светлана , Tyurina Svetlana 
Published: October 2017

The article deals with copyright principles of construction the educational system of the group. Large and responsible tasks in the field of education are also faced by teachers of technical disciplines. In modern conditions, it is absolutely necessary that the teaching skills allow them to solve the most difficult tasks.
In this article are proposed copyright principles of construction the educational system of the group, which are implemented during the development of the program of training of mid-level professionals with a degree 15.02.08 mechanical engineering. And for today they give positive results.
Automated Earnings Forecasts: Beat Analysts or Combine and Conquer?
Authors: Ball Ryan T. , Ghysels Eric 
Published: October 2017

Prior studies attribute analysts’ forecast superiority over time-series forecasting models to their access to a large set of firm, industry, and macroeconomic information (an information advantage), which they use to update their forecasts on a daily, weekly or monthly basis (a timing advantage). This study leverages recently developed mixed data sampling (MIDAS) regression methods to synthesize a broad spectrum of high frequency data to construct forecasts of firm-level earnings. We compare the accuracy of these forecasts to those of analysts at short horizons of one quarter or less. We find that our MIDAS forecasts are more accurate and have forecast errors that are smaller than analysts’ when forecast dispersion is high and when the firm size is smaller. In addition, we find that combining our MIDAS forecasts with analysts’ forecasts systematically outperforms analysts alone, which indicates that our MIDAS models provide information orthogonal to analysts. Our results provide preliminary support for the potential to automate the process of forecasting firm-level earnings, or other accounting performance measures, on a high-frequency basis. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2864 . This paper was accepted by Mary Barth, accounting.
Sex Ratio And Size At First Maturity Of Blue Swimming Crab (Portunus pelagicus) Salemo Island Pangkep Regency
Authors: Nurdin Muh. Saleh , Ali Syamsu Alam , Satari Dewi Yanuarita 
Published: October 2017

Blue swimming crab (Portunuspelagicus) is aeconomical valuable fisheries importantcommodity due to the high demand and availability jobs created for the fishermen. Due to their high demand blue swimming crab heavily exploited from Salemo Island. This study aimed at comparing the sex ratio and the size at first maturity of blue swimming crab caught in mangrove ecosystems, coral reefs, and seagrass. Sex ratio was analyzed using chi square test and the size at first maturity was analyzed using the Spearman-Karber formula. The results showed the sex ratio ofmales and femalessmall crab caught in every ecosystem is balanced. The size at first maturity of blue swimming crab caught in mangrove, seagrass and coral reefs, each to the male 81,08 mm, 102,36 mm and 102,87 mm in width and size of female 94,54 mm, 83,35 mm, 98,31 mm width. In a reference to government regulations, the blue male swimming crab caught in the coral reef and seagrass ecosystems have yet to size at first maturity is allowed to be captured. Keywords: blue swimming crab, sex ratio,size at first maturity, Salemo Island
The Effect of CO2 Injection on Macroalgae Gelidium latifolium Biomass Growth Rate and Carbohydrate Content
Authors: Kawaroe Mujizat , Sunuddin Adriani , Augustine Dina , Lestari Dea Fauzia 
Published: October 2017

There are many species of macroalga grow in marine ecosystem and potentially as raw material for bioethanol resource. Bioethanol is a conversion result of carbohydrate, one of macroalgae biomass content. The exploration of macroalgae require information about growth rate ability to determine availability in the nature. This research analyze growth rate and carbohydrate content of marine macroalga Gelidium latifolium on cultivation using varied injection of carbon dioxide and aeration. The treatments were control (K), 2000 cc CO2 injection and aeration (P1), 3000 cc CO2 injection and aeration (P2), 2000 cc CO2 injection without aeration (P3), and 3000 cc CO2 injection without aeration (P4). Samples weight were 3 gram in early cultivation on laboratorium scale for 42 days observation. The results showed that the daily growth rate Gelidium latifolium during the study ranged from 0.02-1.06%. The highest daily growth rate was 1.06±0.14% (P2). Carbohydrate yield was 18.23% in early cultivation then 19.40% (K and P2), 20.40% (P1), 16.87% (K3), and 16.40% (P4) after cultivation. The high of carbohydrates value may not guarantee the sustainable Gelidium latifolium biomass utilization as raw material for bioethanol production because of the low growth rate, thus it is necessary to modified and encourage cultivation method effectively. Keywords: CO2 injection, growth rate, carbohydrate, macroalgae, Gelidium latifolium
Burrowing Time of the Three Indonesian Hippoid Crabs After Artificial Dislodgment
Authors: Wardiatno Yusli , Qonita Yuyun , Hakim Agus Alim 
Published: October 2017

Three species of hippoid crabs are the target species of intertidal fishery along coastal line in District Cilacap, south Java; namely Emerita emeritus, Hippa adactyla and Albunea symmista. In Adipala sandy beach, Cilacap an experiment was conducted to reveal the burrowing time and velocity of the crabs. The experiment was performed by removing the crabs from their burrows, measuring their carapace length, and releasing them immediately on the substrate. Burrowing time was measured from the start of burrowing to the disappearance of the entire carapace under the sediment surface. Among the three species, E. emeritus had the fastest burrowing time. As a consequence in terms of velocity, the burrowing velocity of Albunea symmista was higher than that of Hippa adactyla and Emerita emeritus; meaning that with the same size A. symmista needs longer time to burrow. By evaluating with other previous studies, the burrowing time and burrowing velocity of the three sand crabs were comparable. The ability of fast burrowing in the three species seems likely to be the advantage for their survival in large wave disturbed coarse sandy habitat and for their ability to widely exist along the sandy coast of south Java. Keywords: behavior; Indian ocean; intertidal; sand crab; south Java; swash zone
Spatial Distribution, Behaviour, and Biological Aspect of Albacore (Thunnus alalunga) Caught in Eastern Indian Ocean
Authors: Rochman Fathur , Jatmiko Irwan , Setyadji Bram 
Published: October 2017

This study highlighted the occurrence of the Indonesian tuna longline fishery targeting albacore (Thunnus alalunga) caught in the Eastern Indian ocean. The data used in this study based on the Research Institute for Tuna Fisheries (RITF) observer program in Benoa. This paper presents the current information on biological aspect (size distribution and length-weight relationship) and fish behavior (swimming layer and feeding periodicity) of albacore. Total albacore samples of 3,152 were taken from scientific observer data from 2010-2013. The study area of albacore was between 0-33°S and 75-131°E. Albacore length distributed from 70-196 cmFL (median=93 cmFL, mode=100 cmFL, mean=92.12 cmFL) and dominated at size of 95 cmFL. The highest percentage length of albacore was >90 cm (L50) occured in the area between (30-35°S and 80-95°E) and (10-15°S and 120-125°E). The length weight relationship was determined to be W=0.0045 FL1.8211 (W in kg, FL in cm). The expected season to catch the ALB was from April to July with the peak season in June and July. The swimming layer of albacore based on minilogger data were distributed from at 118 to 341 m depth and mostly catch at depth of 156 m with temperature degree 18°C. The feeding periodicity of albacore’s are start from 7:45am to 17:59 pm, mostly active at 10 am to 11 am. The majority of ALB caught by Indonesian longliner was mature condition and negative allometric growth. The ALB peak season was in June-July and the best time to catch was 10 am to 11 am at depth of 156 m. Keywords : albacore, feeding periodicity, swimming layer, CPUE
Fate of Heavy Metals Pb and Zn in the West Season at Jeneberang Estuary, Makassar
Authors: . Najamuddin , Prartono Tri , Sanusi Harpasis S , Nurjaya I. Wayan 
Published: October 2017

The pollutant quantity of heavy metals entering water environment does not give complete answer toward the generated effect and risk, however it needs thoroughly study related to the pollutant dynamic. The aim of this research was to investigate the fate of Pb and Zn in water, such as: distribution, behavior, and reactivity (case study: Jeneberang Estuary, Makassar). Pb and Zn concentrations were determined using Atomic Absorption Spectrophotometry (AAS). The distribution of dissolved Pb and Zn showed a pattern that the lowest concentration was in the fresh water (the river zone), whereas the highest concentration was in the salt water (the marine zone). The distribution pattern of particulate Pb and Zn showed that the highest concentration was in the fresh water (the river zone) and the salt water (the marine zone), whereas the lowest concentration was in the estuary zone. The behavior of dissolved Pb and Zn tended to increase the concentration (desorption) along the increased salinity gradient. The residual fraction was the dominant component of geochemical fractions in the sediment that indicated the sources of Pb and Zn mainly derived from a natural process and the reactivity was low in the water. Keywords: distribution, behavior, reactivity, lead, zinc, pollution
Aplikasi silika dan NAA terhadap pertumbuhan Anggrek Bulan (Phalaenopsis amabilis l.) pada tahap aklimatisasi
Authors: Nikmah Ziadatul Choirum , Slamet Widyati , Kristanto Budi Adi 
Published: October 2017

The purpose of the research was to study the influence silica and concentration of NAA for moon orchid (Phalaenopsis amabilis L.) growth in acclimatization. The experiment was assigned in completely randomized factorial design with the first factor was silica (non silika and with silica) and the second factor was NAA concentrations (0, 50, 100, and 150 ppm). Each treatments was repeated three times. Parameters measured were the percentage of plant life, number of leaves, length of leaf, width of leaf, number of roots, length of root and fresh weight of plants. Data were subjected to ANOVA and followed by Duncan Multiple Range Test. The result showed that aplication silica increased fresh weight of plants. Application of NAA concentrations (50, 100, and 150 ppm) decreased percentage of plant life, leaght of leaf, and fresh weight of plants. Interaction of silica and NAA concentrations showed did not significantly effect. Keyword : Moon orchid, silica, NAA, aclimatization
Respon pertumbuhan dan produksi tanaman sawi Pakcoy (Brassica chinensis L.) akibat pemberian berbagai jenis pupuk kandang
Authors: Barokah Rahmadun , Sumarsono Sumarsono , Darmawati Adriani 
Published: October 2017

The purpose of this research was to determine growth and production responses of Spoon Mustard (Brassica chinensis L.) due to the treatment of various type of manure and to determine types of manure which effective for the growth and production of Spoon Mustard. This Research has been conducted at Experimental field and Laboratory of Plants’s Ecology and Production, Faculty of Animal and Agricultural Science, Diponegoro University from January to March 2017. This research used monofactorexperiment in Completely Randomized design arrangement. The treatment was variation of manure which were cow manure, goat manure, sheep manure, horse manure, and chicken manure, they would be compared with nontreatment (0 fertilizer) and 300 kg/ha urea in four times replication. The obtained data were processed statistically with analysis of variance (F test) and Duncan Multiple Range Test at 5% level. The result’s showed that manure treatment with different types gave effect to the plant heigh, number of leaves, leaf area, and plant production. The best treatment was chicken manure treatment which produced average of plant height as 26,33 cm, average of number of leaves as 11sheet, average of leaf area as 1033,30 cm, and Spoon Mustard production as 2319,90 g/m2.Keywords: Organic Fertilizer, Manure, Pakcoy.
Solution of 2-D Inverse Heat Conduction Problem with Graphic Accelerator
Authors: Felde I. , Fried Z. , Szénási S. 
Published: October 2017

Abstract
The parallelized particle swarm optimization (PSO) method has been developed to solve inverse heat transfer problems. Temporal- and spatial-dependent heat transfer coefficient functions obtained on the surfaces of axis-symmetrical work pieces are estimated by applying the novel technique. The goal function to be minimized by the PSO approach is defined by the deviation of the measurements and the calculated temperatures. The PSO algorithm has been parallelized and implemented on a graphic processing unit (GPU) architecture. Numerical results demonstrate that the determination of heat transfer coefficient functions can be performed by using the parallelized PSO method as well as the GPU implementation and that they provide a less time-consuming and more accurate estimation.
How do online sports gambling disorder patients compare with land-based patients?
Authors: Estévez Ana , Rodríguez Raquel , Díaz Noelia , Granero Roser , Mestre-Bach Gemma , Steward Trevor , Fernández-Aranda Fernando , Aymamí Neus , Gómez-Peña Mónica , Pino-Gutiérrez Amparo del , Baño Marta , Moragas Laura , Mallorquí-Bagué Núria , López-González Hibai , Jauregui Paula , Onaindia Jaione , Martín-Romera Virginia , Menchón José M. , Jiménez-Murcia Susana 
Published: October 2017

Background and aims
Recent technological developments have brought about notable changes in the way people gamble. The widespread use of mobile Internet devices and gambling websites has led to a significant leap in the number of people who recreationally gamble. However, for some, gambling can turn into a psychiatric disorder resembling substance addiction. At present, there is a shortage of studies examining differences between adults with gambling disorder (GD) who exclusively make sports bets online, GD patients that are non-sports Internet gamblers, and offline gamblers. Therefore, this study was undertaken to determine the differences between these three groups, considering sociodemographic, personality, and clinical characteristics.

Methods
The sample consisted of 2,743 treatment-seeking male patients from the Pathological Gambling Unit at a university hospital. All patients met DSM-5 criteria for GD.

Results
We found that gamblers who exclusively engaged in non-sports Internet gambling activities were younger than offline gamblers and online sports gamblers. Non-sports Internet gamblers were also more likely to have greater levels of debt compared with offline gamblers. In terms of personality characteristics, our sample displayed low levels of self-directedness and cooperativeness and high levels of novelty seeking. In addition, online sports gamblers obtained higher scores in persistence than non-sports Internet gamblers and offline gamblers.

Discussion and conclusion
Although differences if terms of gambling severity were not identified between groups, GD patients who exclusively bet online appear to possess distinct personality characteristics and higher debt levels compared with offline gamblers.