bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children
Authors: Nordman Henrikki , Voutilainen Raimo , Antikainen Leena , Jääskeläinen Jarmo 
Published: February 2018

Abstract

Context
Birth size has an impact on later cardiometabolic risk that is strongly related to low-grade inflammation.

Objective
To evaluate plasma interleukin-1 receptor antagonist (IL-1ra) concentrations in relation to birth size and cardiometabolic and inflammatory markers in prepubertal children.

Design
A cohort study. Anthropometric data were recorded. Fasting blood samples were collected for plasma analyses of IL-1ra, alanine transaminase, total cholesterol, high- and low-density lipoprotein cholesterols, triglyceride, glucose, and serum analyses of 25-hydroxyvitamin D [25(OH)D] and high-sensitivity C-reactive protein (hs-CRP) concentrations.

Participants
Forty-nine large for gestational age (LGA), 56 appropriate for gestational age, and 23 small for gestational age (SGA) children at 5 to 8 years of age were examined.

Main Outcome Measures
Differences in IL-1ra concentrations among the birth-size groups and associations between IL-1ra and other metabolic markers were assessed.

Results
Body mass index (BMI) standard deviation score (SDS)-adjusted plasma IL-1ra concentrations were highest in the SGA- and lowest in the LGA-born children (P = 0.015). Age- and sex-adjusted IL-1ra concentrations had strongest associations with BMI SDS (P &lt; 0.001) and hs-CRP (P &lt; 0.001, also when further adjusted for BMI SDS).

Conclusions
Prepubertal children born SGA had the highest and those born LGA the lowest IL-1ra concentrations in this study cohort. Most associations found between IL-1ra and the studied metabolic parameters were weight related, but the association with hs-CRP remained strong after adjustment for BMI. It seems that at prepuberty, SGA children have a stronger inflammatory state than LGA children and may thus be at a greater risk for later metabolic disturbances.
The Effect of Prescription Drug Monitoring Programs on Opioid Utilization in Medicare
Authors: Buchmueller Thomas C. , Carey Colleen 
Published: February 2018

The misuse of prescription opioids has become a serious epidemic in the United States. In response, states have implemented Prescription Drug Monitoring Programs (PDMPs), which record a patient’s opioid prescribing history. While few providers participated in early systems, states have recently begun to require providers to access the PDMP under certain circumstances. We find that “must access” PDMPs significantly reduce measures of misuse in Medicare Part D. In contrast, we find that PDMPs without such provisions have no effect. We find stronger effects when providers are required to access the PDMP under broad circumstances, not only when they are suspicious. (JEL H75, I11, I12, I18)
Ο εμπορικός χάρτης της βυζαντινής Θεσσαλονίκης: ιχνηλατώντας τις αγορές της πόλης από τον 9ο αιώνα έως την οθωμανική κατάκτηση.
Authors: ΡΑΠΤΗΣ (Konstantinos Th. RAPTIS) Κωνσταντίνος Θ. 
Published: February 2018

Με βαση περιορισμένα αρχαιολογικά δεδομένα και αναφορές σε κείμενα της βυζαντινής περιόδου επιχειρείται η ανίχνευση των περιοχών της βυζαντινής Θεσσαλονίκης, στις οποίες αναπτυσσόταν περισσότερο ή λιγότερο οργανωμένη εμπορική δραστηριότητα και αφετέρου η σκιαγράφηφη, έστω και θολά, του εμπορικού χάρτη της πόλης από την μέση βυζαντινή περίοδο έως την Οθωμανική κατάκτηση.
Cross-cultural interaction and convergence in the hospitaller states. The case of the cult of Saint Panteleemon in Telos
Authors: PAPANIKOLAOU (Πρόδρομας ΠΑΠΑΝΙΚΟΛΑΟΥ) Prodromos 
Published: February 2018

Η μικρή λιτανική εικόνα από το μοναστήρι του Αγίου Παντελεήμονα της Τήλου, πιθανότατα έργο τοπικού εργαστηρίου, αξιολογείται σε συνδυασμό με άλλεςκαλλιτεχνικές ενδείξεις, τόσο ζωγραφικές όσο και αρχιτεκτονικές, υπό το πρίσμα της λατρείας του αγίου Παντελεήμονα. Η ανάπτυξη της λατρείας του στα τέλη του 15ου αιώνα πιθανολογείται ότι αποτέλεσε σημείο σύγκλισης μεταξύ Ελλήνων και Λατίνων στη Ρόδο.
The sunflower oil and the sunflower meal in animal nutrition
Authors: BONOS (Ε. ΜΠΟΝΟΣ) E. , CHRISTAKI (Ε. ΧΡΗΣΤΑΚΗ) E. , FLOROU-PANERI (Π. ΦΛΩΡΟΥ-ΠΑΝΕΡΗ) P. 
Published: February 2018

The sunflower plant (Helianthus annuus) is an annual herbaceous plant of the Asteraceae family. It is grown primarily for its seeds, the sunflower oil and the sunflower meal obtained from it, but also as an ornamental plant, as feed and as fuel. The sunflower seed is comprised from the husk on the outside and the kernel on the inside, whereas depending on the oil content it is categorised in two varieties, one with low oil content (average 25%) and another with high oil content (40% - 51%). The sunflower oil is high in unsaturated fatty acids, vitamin E and plant sterols and low in saturated fatty acids. The fatty acids composition of the sunflower oil depends mainly on the variety of the sunflower seeds and thus the sunflower oil is categorised in linoleic sunflower oil or classic (with high polyunsaturated fatty acids content), oleic sunflower oil or High-oleic (with a high monounsaturated fatty acids content) and middle oleic sunflower oil or NuSun (with an intermediate oleic acid content). It is marketed as raw oil or refined oil. The sunflower oil is added to the rations of farm animals in order to increase their energy content and to meet their essential fatty acids needs. Nowadays, many researchers study its effect on the composition of milk, meat and eggs produced from farm animals, in order to obtain characteristics more desirable for the human consumers, such as higher concentration of unsaturated omega-3 and omega-6 fatty acids, as well as higher concentration of conjugated linoleic acid (CLA). The sunflower meal is the main byproduct of the sunflower seeds after oil extraction. Sunflower meal may differ in color and texture, as well as in their chemical composition, depending on the variety of the sunflower, the degree of hull removal and the method of treatment. The crude fiber content varies from 12% to 32%, the crude protein from 24% to 44% and the ether extract from 1% to 10%. It also contains a significant amount of vitamins and non-starch polysaccharides. The sunflower oil and the sunflower meal can be used in the nutrition of both monogastric animals and ruminants.
Prevalence of failure of passive transfer of immunoglobulins in Holstein calves in Northern Greece and association with management practices
Authors: PANOUSIS (Ν. ΠΑΝΟΥΣΗΣ) N. , KRITSEPI- KONSTANTINOU (Μ. ΚΡΙΤΣΕΠΗ-ΚΩΝΣΤΑΝΤΙΝΟΥ) M. , KALAITZAKIS (Ε. ΚΑΛΑΪΤΖΑΚΗΣ) E. , GIADINIS (Ν. ΓΙΑΔΙΝΗΣ) N. , VALERGAKIS (Γ.Ε. ΒΑΛΕΡΓΑΚΗΣ) G. E. 
Published: February 2018

Objectives of the present study were to estimate prevalence of failure of passive transfer of immunoglobulins in dairy calves in Northern Greece and to investigate factors potentially associated with it. Four hundred and thirty seven clinically healthy calves in 30 farms were included in the study. Age of calves was 18 h to 7 d. Animals were blood sampled and serum total protein concentrations were measured by a refractometer. Two thresholds of total protein concentration were used: 5.2 or 5.5 g dL 1. At calf level, an animal was considered to have failure of passive transfer of immunoblobulins when total protein concentrations were lower than the above thresholds. At herd level, a herd was considered to have failure of passive transfer of immunoglobulins when >20% of sampled calves had total protein concentration was <5.2 or <5.5 g dL-1.Moreover, data on health management on the farm were collected in a purpose-built questionnaire. At 5.2 g dL-1, 20% of the calves and 40% of the herds were considered to have failure of passive transfer of immunoglobulins; when the 5.5 g dL-1 threshold was used, respective prevalences were 26% and 53%. At herd level, mean blood serum total protein concentration tended to be positively affected by a short interval between birth and first colostrum meal, by maintenance of a stock of frozen colostrum and by establishment of a close-up group of dry cows. At calf level, the same factors had a statistically significant positive effect on blood serum total protein concentration. Moreover, quantity of colostrum received by calves and colostrum condition were also positively related with blood serum total protein concentration. In conclusion, failure of passive transfer of immunoglobulins is a common problem in Holstein calves in Northern Greece. Increased prevalence of the problem implies that increased efforts and management practices need to be applied to ensure the adequate transferof maternal immunoglobulins to newborn calves. Also, it becomes obvious from all the above findings that many farmersare not well informed for management practices that have to implement to ensure adequate amounts of immunoglobulins tonewborn calves. Hence, dissemination of knowledge concerning best management practices for achieving adequate passiveimmunity is considered to be of significant importance.
Suspected toxicity by biological waste and air sac nematode infestation in a free-living peregrine falcon (Falco peregrinus)
Authors: AZMANIS (Π.Ν. ΑΖΜΑΝΗΣ) P. N. , KRAUTWALD-JUNGHANNS M.-E. , SCHMIDT V. 
Published: February 2018

This case report describes an uncommon complex of mortality in a free living peregrine falcon (Falco peregrinus). The bird was found rinsed with biologic waste and the integument was mildly inflamed. No respiratory signs were detected at first. In addition, no alterations were detected during. During orthopaedic, neurologic, ophthalmologic and radiographic examinations. Parasitological pharyngeal and faecal examination revealed Capillaria spp. and Serratospiculum spp. eggs. The therapeutic scheme included stress reduction, supportive therapy with fluids, antifungals, antibiotics, anti-inflammatory, antiparasitic agents and nutritional management. Cleaning with dishwashing gel to remove the biological waste took place, but its removal was partial. Despite the intensive care, the patient developed respiratory distress and succumbed on the fifth day of hospitalization. Pathological examination revealed adult Serratospiculum tendo parasites in the air sacs and Capillaria spp. in the large intestine. Bacteriological and mycological cultures revealed significant growth of Klebsiella pneumoniae isolated from the skin, heart, lung, liver, kidney and intestine and a mild presence of Candida albicans in the large intestine. Their probable role was judged as secondary. Mild multifocal haemorrhages with heterophilic and lymphohistiocytic infiltrates, fibrin and rod‑like bacteria were detected in the skin histopathologically, confirming the clinical integument inflammation. Cause of death was asphyxia caused by oedema, haemorrhages and blood congestion of the lung. The contribution of S. tendo in the initial spill event and case evolution is discussed. This unusual case highlights the complexity of the wildlife cases, with which avian or small animal clinicians (consulting rehabilitation centres or falconers) might be confronted. Although the application of ancillary and advanced diagnostic tools, the in-depth knowledge of the species and the intensive monitoring are important, this might lead to an unrewarding outcome. Financial constraints in wildlife casualty cases urge the critical choice of diagnostic, therapeutic and post-mortem laboratory testing. Serratospiculum tendo should be considered in the differential diagnosis of acute respiratory distress in free-living peregrine falcons, presented in rehabilitation centres or in private practise by falconers in Greece and Europe.
La configuración espacial de las clases alta y media en Cali: el caso de la urbanización Miraflores 1947-1950
Authors: Sánchez Salcedo José Fernando 
Published: February 2018

Este artículo tiene como propósito estudiar el proceso de reconfiguración socio-espacial que se llevó a cabo en la ciudad de Cali durante la primera mitad del siglo xx, fruto de las transformaciones socioeconómicas que caracterizaron la región y que redundaron en un importante crecimiento de la población y en la consecuente demanda de vivienda urbana. Específicamente se centra en mostrar los primeros años del proceso de urbanización del barrio Miraflores, a partir de una estrategia metodológica que combina el análisis de fuentes documentales —como escrituras, fotos y mapas— y la historia oral, recogida mediante entrevista a algunos pobladores del barrio. El trabajo realizado muestra el proceso de segmentación que experimentó la ciudad en materia urbana a partir de la zonificación de sectores residenciales para estratos diferenciados, así como algunas características de sus pobladores, entre los cuales se cuentan comerciantes, empleados, ejecutivos de empresas e industrias de la época, y algunos extranjeros.
El espacio urbano ‘calle’ a través de la mirada del paisaje sonoro. Una propuesta metodológica
Authors: Quintero Carolina Alejandra , Recuero López Manuel 
Published: February 2018

El artículo presenta la metodología de análisis de la calle a partir del paisaje sonoro, llevada a cabo en la ciudad de Maracaibo -Venezuela. Su método se orienta desde la fenomenología y la psicoacústica, y en él se abordan dos fases: la mirada de la imagen y la escucha, que se registra través de la técnica del paseo sonoro, de la interpretación de los espectrogramas y de las encuestas. Como resultado de esto surge una visión multidimensional del espacio que permite caracterizar las diferencias del paisaje desde el ambiente sonoro, expresando relaciones de nitidez o claridad con los niveles de legibilidad de la imagen urbana.
Cost minimization analysis of the treatment of distal radial fractures in the elderly
Authors: Pang E. Q. , Truntzer J. , Baker L. , Harris A. H. S. , Gardner M. J. , Kamal R. N. 
Published: February 2018

Aims The aim of this study was to test the null hypothesis that there is no difference, from the payer perspective, in the cost of treatment of a distal radial fracture in an elderly patient, aged > 65 years, between open reduction and internal fixation (ORIF) and closed reduction (CR). Materials and Methods Data relating to the treatment of these injuries in the elderly between January 2007 and December 2015 were extracted using the Humana and Medicare Advantage Databases. The primary outcome of interest was the cost associated with treatment. Secondary analysis included the cost of common complications. Statistical analysis was performed using a non-parametric t-test and chi-squared test. Results Our search yielded 8924 patients treated with ORIF and 5629 patients treated with CR. The mean cost of an uncomplicated ORIF was more than a CR ($7749 versus $2161). The mean additional cost of a complication in the ORIF group was greater than in the CR group ($1853 versus $1362). Conclusion These findings show that there are greater payer fees associated with ORIF than CR in patients aged > 65 years with a distal radial fracture. CR may be a higher-value intervention in these patients. Cite this article: Bone Joint J 2018;100-B:205–11.
The presence of Waddell signs depends on age and gender, not diagnosis
Authors: Yoo J. U. , McIver T. C. , Hiratzka J. , Carlson H. , Carlson N. , Radoslovich S. S. , Gernhart T. , Boshears E. , Kane M. S. 
Published: February 2018

AimsThe aim of this study was to determine if positive Waddell signs were related to patients’ demographics or to perception of their quality of life.Patients and MethodsThis prospective cross-sectional study included 479 adult patients with back pain from a university spine centre. Each completed SF-12 and Oswestry Disability Index (ODI) questionnaires and underwent standard spinal examinations to elicit Waddell signs. The relationship between Waddell signs and age, gender, ODI, Mental Component Score (MCS), and Physical Component Score (PCS) scores was determined.ResultsOf the 479 patients, 128 (27%) had at least one positive Waddell sign. There were significantly more women with two or more Waddell signs than men. The proportion of patients with at least one positive Waddell sign increased with age until 55 years, and then declined rapidly; none had a positive sign over the age of 75 years. Functional outcome scores were significantly worse in those with a single Waddell sign (p < 0.01). With one or more Waddell signs, patients’ PCS and ODI scores indicated a perception of severe disability; with three or more Waddell signs, patients’ MCS scores indicated severe disability. With five Waddell signs, ODI scores indicated that patients perceived themselves as crippled.ConclusionPositive Waddell signs, a potential indicator of central sensitization, indicated a likelihood of having functional limitations and an impaired quality of life, particularly in young women. Cite this article: Bone Joint J 2018;100-B:219–25.
Altered expression of microRNA during fracture healing in diabetic rats
Authors: Takahara S. , Lee S. Y. , Iwakura T. , Oe K. , Fukui T. , Okumachi E. , Waki T. , Arakura M. , Sakai Y. , Nishida K. , Kuroda R. , Niikura T. 
Published: February 2018

ObjectivesDiabetes mellitus (DM) is known to impair fracture healing. Increasing evidence suggests that some microRNA (miRNA) is involved in the pathophysiology of diabetes and its complications. We hypothesized that the functions of miRNA and changes to their patterns of expression may be implicated in the pathogenesis of impaired fracture healing in DM.MethodsClosed transverse fractures were created in the femurs of 116 rats, with half assigned to the DM group and half assigned to the control group. Rats with DM were induced by a single intraperitoneal injection of streptozotocin. At post-fracture days five, seven, 11, 14, 21, and 28, miRNA was extracted from the newly generated tissue at the fracture site. Microarray analysis was performed with miRNA samples from each group on post-fracture days five and 11. For further analysis, real-time polymerase chain reaction (PCR) analysis was performed at each timepoint.ResultsMicroarray analysis showed that there were 14 miRNAs at day five and 17 miRNAs at day 11, with a greater than twofold change in the DM group compared with the control group. Among these types of miRNA, five were selected based on a comparative and extended literature review. Real-time PCR analysis revealed that five types of miRNA (miR-140-3p, miR-140-5p, miR-181a-1-3p, miR-210-3p, and miR-222-3p) were differentially expressed with changing patterns of expression during fracture healing in diabetic rats compared with controls.ConclusionsOur findings provide information to further understand the pathology of impaired fracture healing in a diabetic rat model. These results may allow the potential development of molecular therapy using miRNA for the treatment of impaired fracture healing in patients with DM. Cite this article: S. Takahara, S. Y. Lee, T. Iwakura, K. Oe, T. Fukui, E. Okumachi, T. Waki, M. Arakura, Y. Sakai, K. Nishida, R. Kuroda, T. Niikura. Altered expression of microRNA during fracture healing in diabetic rats. Bone Joint Res 2018;7:139–147. DOI: 10.1302/2046-3758.72.BJR-2017-0082.R1.
Jubblies, mammaries and boobs: Discourses of breast physics in video games
Authors: Rogers Ryan , Liebler Carol 
Published: February 2018

Abstract
Also referred to as ‘jiggle physics’ or ‘breast bounce’, breast physics refer to the animation of a female video game character’s breasts in order for it to seem more realistic or more sexually appealing. To date, many studies have examined the role of women (players, characters and content producers) in video games and have found evidence that women can be underrepresented or presented as highly sexualized. The current study expands on this body of work by examining breast physics, one aspect of video games that lacks attention in the scholarly literature. This study examines discourse in the gaming community via journalistic reports of breast physics in video games. Explicit in these posts are instances in which women are presented for the consumption of others.
CARBONATE BIOFACIES AND PALEOECOLOGY ANALYSIS BASED ON ACROPORA CORAL IN UJUNGGENTENG AREA, WEST JAVA PROVINCE, INDONESIA
Authors: Santoso Wahyu Dwijo 
Published: February 2018

Biofacies concept was proposed to approach the carbonate facies determination by using coral species description and ecology reconstruction. Ujunggenteng area was selected for this study because it has modern carbonate rocks with continues distribution and contains many well-preserved coral fossils. Ujunggenteng area can be distinguished into three biofacies: Acropora cervicornis – Acropora palifera biofacies, Acropora gemmifera – Acropora humilis biofacies, and Acropora cervicornis – Acropora palmata biofacies. The paleobathymetry analysis had indicated that Acropora cervicornis – Acropora palifera biofacies grew in the deepest environment, between 8 – 13 meters depth. Acropora gemmifera – Acropora humilis biofacies lived in a shallower environment between 3 – 8 meters depth, and Acropora cervicornis – Acropora palmata biofacies was deposited between 0 – 3 meters. The Mg/Ca trend showed a negative correlation with the paleobathymetry result. Decreasing Mg/Ca ratio was related to increasing paleobathymetry. Acropora cervicornis – Acropora palifera biofacies has the smallest Mg/Ca ratio, between 14 – 15 mmol. Acropora gemmifera – Acropora humilis biofacies has Mg/Ca ratio between 17 – 21 mmol. Acropora cervicornis – Acropora palmata biofacies has the highest Mg/Ca ratio, between 23 – 24 mmol. Mg/Ca ratio value was related to paleotemperature, in which the decreasing of Mg/Ca ratio associated to decreasing paleotemperature.Konsep biofasies dipilih dan diajukan sebagai salah satu pendekatan untuk penentuan fasies karbonat. Daerah Ujunggenteng dipilih untuk studi ini karena daerah ini menunjukkan perkembangan batuan karbonat yang menerus dan fosil koral yang terawetkan dengan baik. Daerah Ujunggenteng dapat dibagi menjadi tiga biofasies, yaitu biofasies Acropora cervicornis – Acropora palifera, biofasies Acropora gemmifera – Acropora humilis biofacies, dan biofasies Acropora cervicornis – Acropora palmata. Analisis paleobatimetri menunjukkan bahwa biofasies Acropora cervicornis – Acropora palifera tumbuh di lingkungan yang paling dalam, yaitu 8 – 13 meter. Biofasies Acropora gemmifera – Acropora humilis hidup di lingkungan yang lebih dangkal, yaitu 3 – 8 meter, dan biofasies Acropora cervicornis – Acropora palmata terendapkan di lingkungan yang lebih dangkal, yaitu 0 – 3 meter. Analisis kadar Mg/Ca menunjukkan nilai yang berlawanan dengan paleobatimetri. Penurunan kadar Mg/Ca memiliki hubungan dengan peningkatan paleobatimetri. Biofasies Acropora cervicornis – Acropora palifera memiliki nilai kadar Mg/Ca paling rendah, yaitu 14 – 15 mmol. Biofasies Acropora gemmifera – Acropora humilis memiliki kadar Mg/Ca yang lebih tinggi dibandingkan dengan biofasies Acropora cervicornis – Acropora palifera, yaitu 17 – 21 mmol. Biofasies Acropora cervicornis – Acropora palmata menunjukkan nilai kadar Mg/Ca yang paling tinggi, yaitu 23 – 24 mmol. Kadar Mg/Ca memiliki hubungan dengan perubahan paleotemperatur. Penurunan kadar Mg/Ca berasosiasi dengan penurunan paleotemperatur.