bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blockade of Orai1 Store-Operated Calcium Entry Protects against Renal Fibrosis
Authors: Mai Xiaoyi , Shang Jinyan , Liang Sijia , Yu Beixin , Yuan Jiani , Lin Yu , Luo Renfei , Zhang Feiran , Liu Yingying , Lv Xiaofei , Li Chunling , Liang Xinling , Wang Weidong , Zhou Jiaguo 
Published: September 2016

Evidence supports an important role of Ca2+ release-activated Ca2+ channel protein 1 (Orai1)-mediated Ca2+ entry in the development of renal fibrosis, a common pathologic feature of CKDs that lead to ESRD, but the molecular mechanisms remain unclear. We determined the role of Orai1 calcium channel in renal fibrosis induced by high-fat diet and by unilateral ureteral obstruction. Mouse kidneys with fibrosis had higher levels of Orai1 protein expression than did kidneys without fibrosis. In vivo knockdown of Orai1 with adenovirus harboring Orai1–short hairpin RNA or inhibition of Orai1 with SKF96365 dramatically prevented renal fibrosis and significantly decreased protein expression of fibronectin, α‑smooth muscle actin, and TGF‑β1 in the kidney cortex of ApoE–/– mice on a high-fat diet and in the obstructed kidneys of mice with unilateral ureteral obstruction. Compared with kidney biopsy specimens of patients with glomerular minimal change disease, those of patients with fibrotic nephropathy had higher expression levels of Orai1. In cultured human proximal tubule epithelial cells (HK2), knockdown of Orai1 Ca2+ channel with adenovirus–Orai1–short hairpin RNA markedly inhibited TGF-β1–induced intracellular Ca2+ influx and phosphorylation of smad2/3. Knockdown or blockade of the Orai1 Ca2+ channel in HK2 cells also prevented epithelial-to-mesenchymal transition induced by TGF‑β1. In conclusion, blockade of the Orai1 Ca2+ channel prevented progression of renal fibrosis in mice, likely by suppressing smad2/3 phosphorylation and TGF-β1–induced epithelial-to-mesenchymal transition. These results render the Orai1 Ca2+ channel a potential therapeutic target against renal fibrosis.
Editorial
Authors: Veltkamp Remco 
Published: September 2016

I am very pleased to introduce this special issue of IJSG, which is dedicated to the Games and Learning Alliance Conference (GaLA Conf), that was held in Rome, December 2015. A number of the best conference papers were selected, and the authors were invited to extend their paper with at least one third new content, and to submit their paper to IJSG to undergo a regular review process. This issue contains five of these papers.
Arquitetura, vazio moderno e o espaço social
Authors: Cruz Luciana Saboia Fonseca 
Published: September 2016

A vanguarda do Movimento Moderno promulgava a inserção de vazios urbanos no tecido urbano compacto da cidade do século XIX. Para os modernos, o espaço urbano edificado conjugado com áreas verdes, áreas amplas e áreas para livre circulação configuraria uma nova ordem social e um habitat social mais aberto ao convívio coletivo. A Glassarchitekture caracterizada por poucos elementos, estruturas esbeltas e vedações transparentes faziam parte principalmente do que Kenneth Frampton denominou de “tradição moderna minimalista”. Essa tectonicidade reduzida ao máximo tornaram-se objetivos estéticos da arquitetura moderna do início do século XX. Os críticos ao modernismo denunciavam os espaços demasiadamente abstratos, onde não há lugar para o acontecimento empírico, para o ornamento ou para o acaso levando a um empobrecimento do ambiente cultural e provocando um ‘esvaziamento’ da esfera pública. Como reconhecer a luta por identidades no espaço projetado e construído? Como reconhecer culturalmente o moderno ou o modernista sem abrir mão de memórias coletivas e tradições passadas? Pretende-se compreender a questão do vazio moderno como espaços de experiência, tanto como fenômenos em constante configuração, como na sua historicidade. Parte-se da premissa de que construções do espaço social não são representações ideais ou totalizantes como os modernistas pregavam. Em uma análise hermenêutica do vazio, a interpretação de memórias e promessas presentes na luta por reconhecimento no cotidiano da cidade planejada e vivenciada rompe com a ideia da arquitetura moderna como objeto original, finalizada na sua concepção e construção.
El oro y riquezas: poder y manipulación de la sociedad y del cosmos en Dánae de Eurípides
Authors: Santis Guillermo De 
Published: September 2016

El presente trabajo pone en discusión la valoración social del dinero, el oro y la riqueza en la sociedad ateniense del siglo V aC. y su poder manipulador de valores tradicionales, a través del análisis de la obra Dánae de Eurípides. Partiendo de la sospecha de Acrisio, acerca de la seducción amorosa que el oro habría producido en su joven hija Dánae, el trabajo indaga la capacidad de la riqueza de legitimar ideas y posiciones socio-políticas frente a valores tradicionales como la virtud, la inteligencia y la oportunidad. Finalmente, el artículo analiza el tema en otras obras trágicas y líricas y propone que, a partir de mediados del siglo VI aC. el oro rivaliza en poder con Érws, tradicional fuerza seductora y manipuladora en el kósmos.
Impact of an Intervention Designed to Reduce Sexual Health Risk Behaviors of African American Adolescents: Results of a Randomized Controlled Trial
Authors: Jenner Eric , Jenner Lynne W. , Walsh Sarah , Demby Hilary , Gregory Alethia , Davis Erin 
Published: September 2016

Objectives. To replicate an evidence-based HIV risk reduction program and assess its impact on 2 behavioral outcomes—inconsistency of condom use and frequency of sex—6 months after the program. Methods. The study was an individual-level randomized controlled trial in which we randomly assigned 850 youths (aged 14–18 years) to 1 of 2 conditions. The treatment (Becoming a Responsible Teen) is a group-level sociocognitive and skills training sexual education course; the control is a general health intervention that includes the same initial informational component as the treatment. Participants were recruited over 3 summers (2012–2014) from a summer employment program in New Orleans, Louisiana, that serves primarily African American adolescents. Results. Six months after program exposure, we found no statistically significant difference between treatment and control group members’ self-reported inconsistency of condom use or frequency of sex (P > .05). Conclusions. Although previous evidence has indicated that this particular program can be effective, this study’s findings indicate that it was not effective in this setting with this specific population. Results should provide an incentive to learn why the intervention works in some cases and what conditions are necessary for causal impacts.
Preventing Pregnancy in High School Students: Observations From a 3-Year Longitudinal, Quasi-Experimental Study
Authors: Gelfond Jonathan , Dierschke Nicole , Lowe Diana , Plastino Kristen 
Published: September 2016

Objectives. To assess whether a sexual health education intervention reduces pregnancy rates in high school students. Methods. We performed a secondary analysis of a 3-year quasi-experimental study performed in South Texas from 2011 to 2015 in which 1437 students without a history of pregnancy at baseline were surveyed each fall and spring. Potentially confounding risk factors considered included sexual behaviors, intentions, and demographics. The outcome measure was self-reported pregnancy status for male and female students. We performed analyses for male and female students using separate discrete time-to-event models. Results. We found no difference in pregnancy rates between intervention and comparison students within the first 3 years of high school. Female and male students in the intervention groups had pregnancy hazard ratios of, respectively, 1.62 (95% CI = 0.9, 2.61; P = .1) and 0.78 (95% CI = 0.44, 1.48; P = .4) relative to the comparison groups. Conclusions. The educational intervention had no impact on the pregnancy rate. Social media tools in pregnancy prevention programs should be adaptive to new technologies and rapidly changing adolescent preferences for these services.
Randomized Trials of the Teen Outreach Program in Louisiana and Rochester, New York
Authors: Robinson William T. , Seibold-Simpson Susan M. , Crean Hugh F. , Spruille-White Briana 
Published: September 2016

Objectives. To evaluate the Teen Outreach Program, a pregnancy prevention program, in 2 community-based settings. Methods. We evaluated the Teen Outreach Program, a 9-month positive youth development program, in 3 cohorts of youths from 2012 to 2015 in 2 states. In Louisiana, 7 agencies participated in an individualized randomized controlled trial, with youths randomly assigned to a treatment or control condition. Fourteen agencies in Rochester, New York, participated in a cluster randomized controlled trial. Results. We found no differences between the intervention and control youths on delay of sexual onset in Louisiana (adjusted odds ratio [AOR] = 0.80; 95% confidence interval [CI] = 0.62, 1.03) or in Rochester, New York (AOR = 0.89; 95% CI = 0.45, 1.77), or for sex with no effective means of birth control (Louisiana, AOR = 1.18; 95% CI = 0.78, 1.78; Rochester, AOR = 0.41; 95% CI = 0.13, 1.27) after controlling for relevant covariates. Conclusions. We found no short-term effects for the offer of the intervention. Research might be needed for the long-term and intermediate impacts of youth development programs on these and other adolescent risk behaviors.
Evaluation of the Be the Exception Sixth-Grade Program in Rural Communities to Delay the Onset of Sexual Behavior
Authors: Piotrowski Z. Harry , Hedeker Donald 
Published: September 2016

Objectives. To investigate the impact of Be the Exception, a newly developed program to delay onset of sexual behaviors, in a White, rural population. Methods. A cluster randomized controlled trial in northwestern Indiana (14 schools, 1776 students, 2011–2015) compared an intervention (5 group sessions and multimedia assembly) with a no-intervention group; both continued usual standard health education. Multilevel mixed-effects logistic regressions with 1455 students measured long-term outcomes 12 months after baseline questionnaire. Results. Intervention group students reported ever having had sexual intercourse and sexual intercourse in past 3 months significantly less often than did the comparison group (1.91% vs 6.29% and 1.09% vs 4.26%, respectively). No statistical differences were observed for reported sexual intercourse in past 3 months with risky behavior (1.23% vs 2.24%), without condom use (1.04% vs 1.73%), or without birth control (1.00% vs 1.53%). Cumulatively, intervention group students significantly more often reported no activity, holding hands, hugging and kissing and less often reported touching above and below the waist, other sex, or sexual intercourse. Conclusions. Be the Exception is effective in delaying the onset of sexual behavior among rural middle school students.
Estimates of Stress-Dependent Properties in Tight Reservoirs: Their Use With Core and Drill-Cuttings Data
Authors: Lopez Jimenez Bruno A. , Piedrahita Jaime , Aguilera Roberto 
Published: September 2016

Summary
The objective of this paper is to present a methodology with drill cuttings for making estimates of porosity, permeability, and compressibility as a function of confining pressures in tight formations.
An easy-to-use stress-dependent permeability correlation is developed by comparing results from experimental work including hysteresis at various combinations of overburden and pore pressures in vertical and horizontal core plugs, and permeabilities determined in the laboratory from drill cuttings. On the other hand, stress-dependent porosity and compressibility correlations with respect to permeability as a function of net confining stress (NCS) are also introduced. The work is important because of the presence of stress-dependent slot and/or microfracture porosities and permeabilities in tight formations that can significantly affect reservoir performance and forecasting.
Recent work has shown that drill cuttings can be used quantitatively for complete petrophysical evaluation and rock-mechanical-properties estimation (Olusola and Aguilera 2013; Ortega and Aguilera 2014). The methods have been shown to be useful in those instances in which cores and specialized well logs are scarce. Porosity and permeability values obtained from the aforementioned works are extended in this paper to quantitative evaluation of stress-dependent properties.
It is concluded that drill cuttings are important direct sources of information that can be used for developing estimates of stress-dependent petrophysical properties particularly in those cases in which cores and specialized logs are scarce or not available. The methodology and stress-dependent-permeability, -porosity, and -compressibility correlations are presented in detail, as well as a practical application for the case of drill cuttings. Although the main and novel contribution is the development of easy-to-use correlations for stress-dependent tight reservoirs with drill cuttings, the correlations can obviously be used if only plug data are available.
Humanidades na UFABC: produção do conhecimento interdisciplinar na pós-graduação
Authors: Penteado Claudio Luis de Camargo , Silva Sidney Jard da , Fonseca Karen Christina Dias da 
Published: September 2016

O presente artigo tem por finalidade estudar a produção da interdisciplinaridade na Universidade Federal do ABC (UFABC), mais especificamente na área de humanidades. Nascida com uma proposta inovadora, a UFABC tem como uma das suas principais características acadêmica a produção do conhecimento interdisciplinar. A partir da análise dos dois programas pioneiros na área de humanidades, o Programa de Ciências Humanas e Sociais (PCHS) e o Programa de Planejamento e Gestão do Território (PGT), o presente artigo apresenta uma avaliação da prática interdisciplinar a partir de três elementos: I) linhas de pesquisa; II) perfil de formação do quadro docente e III) produções em co-autoria. Os resultados indicam que em ambos os programas existe produção interdisciplinar, contudo cada programa adota uma perspectiva de interdisciplinaridade específica. O primeiro (PCHS) centrado no próprio conceito de interdisciplinaridade e o segundo (PGT) centrado no conceito de território.
Auditors' Constraining Effect on Tax Noncompliance at Different Book-Tax Conformity Levels in a Transition Economy
Authors: Chan K. Hung , Luo Rebecca , Mo Phyllis Lai Lan 
Published: September 2016

ABSTRACT
This study examines how differential auditor quality can affect clients' tax noncompliance at different book-tax conformity levels. Overall, we find that high-quality auditors are associated with client firms' better tax compliance. Specifically, high-quality auditors are effective in constraining book-tax-conforming noncompliance because of the direct linkage between financial and tax reporting for such noncompliance at both the higher and the lower conformity periods. In contrast, high-quality auditors' constraining effect on book-tax-difference noncompliance is significant only in the lower conformity period when there are more opportunities for reporting irregularities. Furthermore, firms that switch from a low- to a high-quality auditor have better tax compliance after the switch. This study contributes to the literature by providing evidence that high-quality auditors not only can constrain clients' earnings management, but can also constrain tax noncompliance.
JEL Classifications: M41; M42.
Water Sorption and Solubility of Luting Agents Used Under Ceramic Laminates With Different Degrees of Translucency
Authors: Leal CL , Queiroz APV , Foxton RM , Argolo S , Mathias P , Cavalcanti AN 
Published: September 2016

SUMMARY
Purpose: The aim of this study was to evaluate the effect of low-thickness ceramic laminate translucency on water sorption and solubility in resin luting agents.
Methods and Materials: Ceramic slides (15×0.7 mm) were generated using lithium disilicate (IPS e.max Press, Ivoclar-Vivadent, Schaan, Liechtenstein) that were A1 in color and had decreasing degrees of translucency (high, medium, and low). A slide of transparent glass of similar size was used as the control. Under each slide, 15 specimens (8×0.5 mm) of differing composite materials from the same manufacturer (3M ESPE Dental Products, St Paul, MN, USA) were prepared (n=5): light-cured resin cement (RelyX Veneer); dual-cured resin cement (RelyX ARC); and flowable composite (Z350XT Flow). To evaluate the loss or gain of mass, the specimens were dried until a constant mass was reached. Then, they were immersed in water for seven days and weighed immediately following removal from water. Subsequently, the specimens were dried again until a constant mass was obtained. The mass measurements were used to calculate the water sorption and solubility. Statistical analyses were carried out using a two-way analysis of variance and the Tukey test.
Results: Under the high-translucency ceramic slides, all of the luting agents showed similar performance regarding water sorption; the flowable composite resin and the light-cured resin cement had the lowest solubility values. Under the medium- and low-translucency surfaces, the dual-cured resin cement and the flowable composite resin showed better performance with respect to water sorption and solubility.
Conclusions: In the case of high-translucency laminates, luting agents with different activation methods might be used. However, even in thin sections, decreasing the translucency of the laminate led to significant loss of light penetration, indicating a decreased likelihood of the physical activation of the resin cement.
Microcomputed Tomography Evaluation of Polymerization Shrinkage of Class I Flowable Resin Composite Restorations
Authors: Sampaio CS , Chiu K-J , Farrokhmanesh E , Janal M , Puppin-Rontani RM , Giannini M , Bonfante EA , Coelho PG , Hirata R 
Published: September 2016

SUMMARY
The present study aimed to characterize the pattern and volume of polymerization shrinkage of flowable resin composites, including one conventional, two bulk fill, and one self-adhesive. Standardized class I preparations (2.5 mm depth × 4 mm length × 4 mm wide) were performed in 24 caries-free human third molars that were randomly divided in four groups, according to the resin composite and adhesive system used: group 1 = Permaflo + Peak Universal Bond (PP); group 2 = Filtek Bulk Fill + Scotchbond Universal (FS); group 3 = Surefil SDR + XP Bond (SX); and group 4 = Vertise flow self-adhering (VE) (n=6). Each tooth was scanned three times using a microcomputed tomography (μCT) apparatus. The first scan was done after the cavity preparation, the second after cavity filling with the flowable resin composite before curing, and the third after it was cured. The μCT images were imported into three-dimensional rendering software, and volumetric polymerization shrinkage percentage was calculated for each sample. Data were submitted to one-way analysis of variance and post hoc comparisons. No significant difference was observed among PP, FS, and VE. SX bulk fill resin composite presented the lowest values of volumetric shrinkage. Shrinkage was mostly observed along the occlusal surface and part of the pulpal floor. In conclusion, polymerization shrinkage outcomes in a 2.5-mm deep class I cavity were material dependent, although most materials did not differ. The location of shrinkage was mainly at the occlusal surface.
A Conservative Technique for Repairing Class IV Composite Restorations
Authors: Ruschel VC , Stolf SC , Shibata S , Baratieri LN 
Published: September 2016

SUMMARY
Composite resin may make a restoration noticeable as time passes, on account of its color instability. The repair technique is a minimally invasive treatment for class IV composite resin restorations that show unsatisfactory coloration. Thus, the objective of the present article was to report a clinical case involving a conservative technique used for repairing a class IV composite resin restoration in the left maxillary central incisor and the replacement of a class IV restoration in the right maxillary central incisor.
Seven-Step Framework for Critical Analysis and Its Application in the Field of Physical Therapy
Authors: Nixon Stephanie A. , Yeung Euson , Shaw James A. , Kuper Ayelet , Gibson Barbara E. 
Published: September 2016

AbstractCritical analysis (or the ability to recognize taken-for-granted assumptions and their effects) is a skill that requires teaching and practice. The purpose of this article is to introduce a framework for critically analyzing assumptions within physical therapy and illustrate its utility through application to 2 examples: a physical therapy clinic logo and an outcome measure for health-related quality of life (HRQOL). This 7-step framework for critical analysis was created for a pilot project to develop reflexivity among senior physical therapist students and further developed through an iterative process of reflecting on its utility for advancing the field of physical therapy. The 7-step framework is an iterative process involving a cascade of 7 steps: (1) name the specific aspect of practice being analyzed, (2) identify the intended purposes of this aspect of practice, (3) uncover the assumptions that support these intended purposes, (4) identify who benefits, (5) identify who is disadvantaged, (6) link these specific ideas to society-level patterns, and (7) conceive of alternatives that mitigate actual or potential harms. It is emphasized that being theoretically critical does not equate to being negative. Rather, the word “critical” is used in the sense of thinking deeply and carefully about the intended and unintended consequences of actions (including common professional practices, ways of speaking, and visual representations) in order to reflect on and mature the field of physical therapy. The purpose of critical analysis is to invite and promote dialogue that assists physical therapist clinicians, researchers, and students to arrive at new insights about the impacts of their day-to-day actions.