bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adhesion barriers in gynecologic surgeries and cesarean section: An Asia‐Pacific expert panel consensus recommendation
Authors: Tanigaki Shinji , Batra Achla , Chan Te‐Fu , Kang Julian Hean‐Leng , Lam Siu‐Keung , Lim Timothy Yong‐Kuei , Mayya Raghavendra , Nur Azurah Abdul Ghani , Walker Graeme 
Published: September 2024

AbstractAdhesions arising from gynecologic surgeries and cesarean sections pose substantial clinical, social, and economic challenges, leading to issues like pelvic pain, infertility, bowel obstruction, and recurring surgeries. Preventing adhesions is a pressing unmet need, hindered by difficulties in assessing postoperative adhesions and understanding barriers. To bridge adhesion prevention gaps, statements on clinical practices were synthesized to present Asia‐Pacific expert perspectives on gynecologic surgery and cesarean section adhesion prevention. An expert panel of eight physicians from various healthcare settings in the Asia‐Pacific region was convened and a comprehensive literature search on topics related to adhesion prevention in gynecologic surgeries and cesarean sections was performed. Information from full‐text publications was used to develop draft consensus statements, with each statement assigned the highest available evidence level based on a systematic literature review and graded using the Oxford Center for Evidence‐based Medicine criteria. A modified Delphi process, involving two rounds of online voting and discussions with an extended group of 109 experts, was employed to reach a consensus on six topics related to adhesion barriers. A set of 15 consensus statements were synthesized. Key topics include adhesion incidence in Asia, cesarean section complications, barrier application status, adhesion formation and prevention, absorbable barriers' effectiveness, recommendations, and future considerations. The statements provide guidance for healthcare professionals, especially in the Asia‐Pacific region, to tackle the challenges posed by postoperative adhesions and improve patient outcomes. Further research is needed to enhance understanding and prevention of adhesions in this region.
Enhancing the accuracy of preoperative and intraoperative evaluation of malignant ovarian germ cell tumors with a focus on fertility preservation in young women
Authors: Ju U Chul , Kang Woo Dae , Kim Seok Mo 
Published: September 2024

AbstractObjectiveTo analyze and improve the accuracy of preoperative assessment and intraoperative frozen‐section analysis (FSA) for malignant ovarian germ cell tumors (MOGCTs), especially in the context of fertility preservation.MethodsA retrospective review of 48 women aged under 40 years, diagnosed with MOGCTs, and treated at Chonnam National University Hospital between July and December 2022 was conducted. The results of preoperative magnetic resonance imaging (MRI), measurement of serum tumor markers (α‐fetoprotein [AFP], β‐human chorionic gonadotropin, lactate dehydrogenase [LDH], cancer antigen [CA] 125, CA 19–9, CA 72–4, carcinoembryonic antigen), and intraoperative FSA were compared with the final pathology diagnosis.ResultsMRI demonstrated a sensitivity of 95.5%, whereas FSA showed a sensitivity of 72.9% for all MOGCTs. Sensitivities varied according to the subtype, but were consistently higher in MRI (100% for dysgerminoma, 88.9% for immature teratoma, 100% for endodermal sinus tumor, 100% for others). However, there were differences in FSA according to subtype (100% for dysgerminoma, 50.0% for immature teratoma, 100% for endodermal sinus tumor, 25.0% for others). Serum tumor markers also provided diagnostic insights, particularly LDH for dysgerminoma (82.4%) and AFP for immature teratoma (75.0%) and endodermal sinus tumor (100%).ConclusionPreoperative MRI and serum tumor marker measurement may be effective in guiding fertility‐sparing surgical decisions. MRI could outperform FSA in terms of accuracy, especially for immature teratoma.
Interaction between intestinal mycobiota and microbiota shapes lung inflammation
Authors: Wang Youxia , He Fang , Liu Bingnan , Wu Xiaoyan , Han Ziyi , Wang Xuefei , Liao Yuexia , Duan Jielin , Ren Wenkai 
Published: September 2024

AbstractGut microbiota is an intricate microbial community containing bacteria, fungi, viruses, archaea, and protozoa, and each of them contributes to diverse aspects of host health. Nevertheless, the influence of interaction among gut microbiota on host health remains uncovered. Here, we showed that the interaction between intestinal fungi and bacteria shaped lung inflammation during infection. Specifically, antifungal drug‐induced dysbiosis of gut mycobiota enhanced lung inflammation during infection. Dysbiosis of gut mycobiota led to gut Escherichia coli (E. coli) overgrowth and translocation to the lung during infection, which induced lung accumulation of the CD45+F4/80+Ly6G−Ly6C−CD11b+CD11c+ macrophages. Clearance of macrophages or deletion of TLR4 (Toll‐like receptor 4, recognition of LPS) rather than Dectin‐1 (recognition of beta‐1,3/1,6 glucans on fungi) blocked the antifungal drug‐induced aggravation of lung inflammation during infection. These findings suggest that the interaction between intestinal mycobiota and commensal bacteria affects host health through the gut–lung axis, offering a potential therapeutic target for ameliorating lung inflammation during infection.
Electrical impedance characterization and modelling of Ti‐Β implants
Authors: Navarro Paula , Barrera Miguel , Olmo Alberto , Torres Yadir 
Published: September 2024

AbstractCommercially pure titanium (c.p. Ti) and Ti6Al4V alloys are the most widely used metallic biomaterials in the biomedical sector. However, their high rigidity and the controversial toxicity of their alloying elements often compromise their clinical success. The use of porous β‐Titanium alloys is proposed as a solution to these issues. In this regard, it is necessary to implement economic, repetitive, and non‐destructive measurement techniques that allow for the semi‐quantitative evaluation of the chemical nature of the implant, its microstructural characteristics, and/or surface changes. This study proposes the use of simple measurement protocols based on electrical impedance measurements, correlating them with the porosity inherent to processing conditions (pressure and temperature), as well as the chemical composition of the implant. Results revealed a clear direct relationship between porosity and electrical impedance. The percentage and/or size of the porosity decrease with an increase in compaction pressure and temperature. Moreover, there is a notable influence of the frequency used in the measurements obtained. Additionally, the sensitivity of this measurement technique has enabled the evaluation of differences in chemical composition and the detection of intermetallics in the implants. For the first time in the literature, this research establishes relationships between stiffness and electrical impedance, using approximations and models for the observed trends. All the results obtained corroborate the appropriateness of the technique to achieve the real‐time characterization of Titanium implants, in an efficient and non‐invasive way.
Nonlinear Optics Through the Field Tensor Formalism
Authors: Duboisset Julien , Boulanger Benoît , Brasselet Sophie , Segonds Patricia , Zyss Joseph 
Published: September 2024

AbstractThe “field tensor” is the tensor product of the electric fields of the interacting waves during a sum‐ or difference‐frequency generation nonlinear optical interaction. It is therefore a tensor describing light interacting with matter, the latter being characterized by the “electric susceptibility tensor.” The contracted product of these two tensors of equal rank gives the light‐matter interaction energy, whether or not propagation occurs. This notion having been explicitly or implicitly present from the early pioneering studies in nonlinear optics, its practical use has led to original developments in many highly topical theoretical or experimental situations, at the microscopic as well macroscopic level throughout a variety of coherent or non‐coherent processes. The aim of this review article is to rigorously explain the field tensor formalism in the context of tensor algebra and nonlinear optics in terms of a general time‐space multi‐convolutional development, using spherical tensors, with components expressed in the frame of a common basis set of irreducible tensors, or Cartesian tensors. A wide variety of media are considered, including biological tissues and their imaging, artificially engineered by various combinations of optical and static electric fields, with the two extremes of all‐optical and purely electric poling, and also bulk single crystals.
Patient‐reported outcome and survival in premenopausal hormone receptor‐positive breast cancer patients at moderate to high risk: comparing toremifene with aromatase inhibitor in a real‐world study
Authors: Yang Yaping , Gan Fengxia , Luo Ting , Lin Qun , Yang Wenqian , Chen Lili , Zhang Wei , Liu Qiang , Gong Chang 
Published: September 2024

AbstractToremifene, a selective estrogen receptor modulator, is commonly used in China for premenopausal breast cancer patients. This real‐world study aimed to compare patient‐reported outcome (PRO) and survival between toremifene and aromatase inhibitor (AI) plus ovarian function suppression (OFS) in patients with moderate‐/high‐risk premenopausal hormone receptor (HR)‐positive breast cancer. The primary endpoint was PROs, assessed using SF‐36 and EQ‐5D‐5L questionnaires between January and March 2023. A total of 392 patients were included, with 171 receiving toremifene and 221 receiving AI. The toremifene group showed significantly higher scores in the role physical (p = 0.034) and mental health (p = 0.009) dimensions of SF‐36 and lower anxiety/depression (AD) scores (p = 0.038) in EQ‐5D‐5L compared to AI group. The estimated 5‐ and 8‐year disease‐free survival (DFS) rates were similar in toremifene and AI groups: 96.5% versus 91.9%, and 87.4% versus 87.8% (p = 0.39), respectively. Adverse event rates were similar in two groups, except for a greater risk of endometrial thickening (p < 0.001) and a lower occurrence of morning stiffness (p < 0.001) in the toremifene compared to the AI group. Premenopausal HR‐positive breast cancer patients receiving toremifene plus OFS had better role physical and mental health outcomes and lower AD dimensions than those receiving AI plus OFS. Both treatments had comparable DFS and favorable tolerability profiles.
A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter
Authors: Ding Qian , Cai Jianghong , Jin Li , Hu Wei , Song Wu , Rose Peter , Tang Zhiyuan , Zhan Yangyang , Bao Leilei , Lei Wei , Zhu Yi Zhun 
Published: September 2024

AbstractSMYD3 (SET and MYND domain‐containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics. No selective inhibitors for this protein have been developed for cancer treatment. Therefore, the current study describes developing and characterizing a novel small molecule ZYZ384 screened and synthesized based on SMYD3 structure. Virtual screening was initially used to identify a lead compound and followed up by modification to get the novel molecules. Several technologies were used to facilitate compound screening about these novel molecules' binding affinities and inhibition activities with SMYD3 protein; the antitumor activity has been assessed in vitro using various cancer cell lines. In addition, a tumor‐bearing nude mice model was established, and the activity of the selected molecule was determined in vivo. Both RNA‐seq and chip‐seq were performed to explore the antitumor mechanism. This work identified a novel small molecule ZYZ384 targeting SMYD3 with antitumor activity and impaired hepatocellular carcinoma tumor growth by reducing H3K4 trimethylation of the Rac1 promoter triggering the tumor cell cycle arrest through the AKT pathway.
The interaction of innate immune and adaptive immune system
Authors: Wang Ruyuan , Lan Caini , Benlagha Kamel , Camara Niels Olsen Saraiva , Miller Heather , Kubo Masato , Heegaard Steffen , Lee Pamela , Yang Lu , Forsman Huamei , Li Xingrui , Zhai Zhimin , Liu Chaohong 
Published: September 2024

AbstractThe innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll‐like receptors to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific and sustained killing of pathogens via B cells, T cells, and antibodies. Traditionally, it has been assumed that innate immunity activates adaptive immunity; however, recent studies have revealed more complex interactions. This review provides a detailed dissection of the composition and function of the innate and adaptive immune systems, emphasizing their synergistic roles in physiological and pathological contexts, providing new insights into the link between these two forms of immunity. Precise regulation of both immune systems at the same time is more beneficial in the fight against immune‐related diseases, for example, the cGAS–STING pathway has been found to play an important role in infections and cancers. In addition, this paper summarizes the challenges and future directions in the field of immunity, including the latest single‐cell sequencing technologies, CAR‐T cell therapy, and immune checkpoint inhibitors. By summarizing these developments, this review aims to enhance our understanding of the complexity interactions between innate and adaptive immunity and provides new perspectives in understanding the immune system.
Anoikis in cell fate, physiopathology, and therapeutic interventions
Authors: Mei Jie , Jiang Xue‐Yao , Tian Hui‐Xiang , Rong Ding‐Chao , Song Jia‐Nan , Wang Luozixian , Chen Yuan‐Shen , Wong Raymond C. B. , Guo Cheng‐Xian , Wang Lian‐Sheng , Wang Lei‐Yun , Wang Peng‐Yuan , Yin Ji‐Ye 
Published: September 2024

AbstractThe extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis is defined as an intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling with intracellular signaling cascades, describing the full process of anoikis. However, anoikis is frequently overlooked in physiological and pathological processes as well as traditional in vitro research models. In this review, we summarized the role of anoikis in physiological and pathological processes, spanning embryonic development, organ development, tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, and so on. Similarly, in the realm of stem cell research focused on the functional evolution of cells, anoikis offers a potential solution to various challenges, including in vitro cell culture models, stem cell therapy, cell transplantation, and engineering applications, which are largely based on the regulation of cell fate by anoikis. More importantly, the regulatory mechanisms of anoikis based on molecular processes and ECM signaling will provide new strategies for therapeutic interventions (drug therapy and cell‐based therapy) in disease. In summary, this review provides a systematic elaboration of anoikis, thus shedding light on its future research.
Nanosilica reinforced epoxy under super high strain rate loading
Authors: Wu Zhibo , Zhang Chenxu , Yin Jianping , Tang Zhongbin , Miao Yinggang 
Published: September 2024

AbstractNanosilica reinforced epoxy‐matrix composites have been extensively investigated for higher mechanical strengths since its emergence, while few literatures are available about enhancement characteristics under super high strain rate loading, which is usually encountered during impact. Hereby, this work investigates the composites containing various kinds of nanosilica subjected to compression of strain rate higher than 20,000 s−1. A series of stress:strain curves are obtained and it is found that peak stresses increase with increasing strain rate along with silica fraction. Excitedly, the silica particle plays another enhancement role in anti‐localization of adiabatic shearing which occurs in pure epoxy, as indicated from abruptly dropped strain‐hardening index at ~22,000 s−1. A mechanism is proposed that uniformly distributed silica delays adiabatic shearing localizations to form through cracks, which is confirmed by fracture surface observance.Highlights
Higher strain rate is achieved experimentally up to ~20,000 s−1.
Strain rate effect is found on the peak stress of composites.
Reinforcement of nanosilica is more distinct on strain‐hardening behavior.
Silica particles hinder adjacent shearing localizations from abrupt evolution.
Consumerist discourses on social media and language teacher educator identity tensions
Authors: Song Juyoung , Nejadghanbar Hassan 
Published: September 2024

AbstractThis study investigates the impact of social media discourses, espoused by neoliberal and consumerist ideologies, on a language teacher educator's (LTE) identity negotiation. Through a collaborative case study, it examines Hassan's (the second author) experiences with social media in the Iranian English language teaching (ELT) context over three years. The data consist of extensive email discussions and four online meetings between the authors over one year. The analysis of Hassan's narratives reveals dominant social media discourses emphasizing sameness, omniscience, and commercialized luxurious lifestyles. These discourses often equate social media visibility with professional qualifications, pressuring Hassan to conform to trends that conflict with his sense of professionalism and authenticity. Hassan's emotional struggles and identity tensions led to critical reflection and ongoing negotiation of his professional identity. The findings underscore the need for professional development programs that support LTEs in navigating the pressures of self‐branding while maintaining their professionalism. Additionally, the study calls for further research into the long‐term effects of social media on professional identity and well‐being across diverse cultural and institutional contexts.
The (im)possible mission of language teacher educators in Germany: Identity formation, development, and practice in institutionalised settings
Authors: Gerlach David 
Published: September 2024

AbstractResearch on language teacher identity and its development has shown that it can be crucial for teacher education to understand how identity development takes place. The few findings to date on language teacher educators and their identities show individual negotiation processes and antinomies, particularly due to transitions from teacher to teacher educator, the parallel roles of researcher and teacher educator, and so on. The project presented here examines the language teacher educator identities of 12 professionals within a highly structured training program in Germany through narrative inquiry as a means to allow for the reconstruction of biographies, identities, and practices. The narratives illustrate the normative settings of the structured system, such as set curricular guidelines, which can rarely be fulfilled by the teacher trainees, a lack of trust and professional relationship, or the struggle of the teacher educators between advisor on the one hand and evaluator on the other. The results provide implications and recommendations for other institutionalised settings in which language teacher educators work.
Home–school connection framework: Elevating multilingual familial engagement capital to build bridges
Authors: Pratt Kristen L. , Emerson Andrea M. , Caires‐Hurley Jaclyn , Dantas‐Whitney Maria 
Published: September 2024

AbstractSchool readiness research points to familial assets as tools for enriching home–literacy and home–school partnerships. This research informs an urgent call for reimagining educator preparedness relative to bridging students' lived experiences at home and school. Developing a multidimensional approach to effectively partnering with multilingual families that centers families as knowledge holders has potential to interrupt persistent opportunity gaps for ethnoracially and linguistically diverse learners. This conceptual paper presents a reconceptualizing of educator preparedness through what we call a home–school connection framework. This framework situates seven principal tenets—asset‐based culturally sustaining foundations, bilingual and bicultural mirrors, authentic cariño (Curry, 2021; Kwon, 2020; Martínez‐Álvarez, 2020; Valenzuela, 1999), reciprocal collaboration, anti‐bias awareness, community valuing of multicultural literature, and familial capital. This framework is applied in practice across each tenet. Preliminary findings suggest the importance of shifting dispositional stance away from educators serving families and toward educators purposefully partnering with families honoring familial engagement capital to inform multilingual multiliteracies in educational spaces.
English in Displacement: Language Learning and Test Preparation Experiences of Refugees and Asylum Seekers
Authors: Séguis Brigita , Miu Heidi , Goldstone Ross 
Published: September 2024

AbstractIn an effort to better support adult and refugee English language learners, this paper aims to focus on understanding the needs and experiences of one specific group, that is, refugee and asylum seeker healthcare professionals (RASHPs), based in the United Kingdom. RASHPs tend to be highly educated and experienced learners. One of their main objectives is to acquire high levels of English language proficiency and possibly return to clinical practice in their new host country. The data for the study come from an online survey that was completed by 106 respondents, followed by interviews conducted with three nurses and nine doctors. Additionally, two language test preparation teachers were also interviewed. The findings show that RASHPs represent a very diverse group of learners, with a range of linguistic backgrounds, age groups, and proficiency levels. Results further reveal that RASHPs often face a range of situational, technological and psycho‐social barriers that may prevent them from fully engaging with their English language and test preparation classes. The study concludes with a series of classroom and policy‐level recommendations that could help ensure better outcomes for refugee and asylum seeker learners.
Exploring Development of EMI Teacher Identities and Emotions During a Collaborative Teaching Practice: A Sociocultural Perspective
Authors: Zhang Shanshan , Xu Jinfen 
Published: September 2024

AbstractThe burgeoning English‐medium instruction (EMI) programs have aroused worldwide scholarly interest in giving language support for EMI subject teachers and their identity‐informed professional development. This study explored how an EMI subject teacher's identities and emotions were intricately interlinked before and after his co‐teaching practice with an English as a foreign language (EFL) teacher at a university in Midwestern China. Ethnographic tools including interviews, observations, and small talks were used over a 10‐month collaborative program. The findings show that the participant teacher's identities and emotions were interdependent with each other and mediated by collaborative teaching practice. Futhermore, emotional attachment to English enhancement and deep engagement in co‐teaching contributed to (re)construction of teacher identities as a content teacher, a competent English user, and an English learning facilitator. The participant's emotional attachment was explicated by his perezhivanie, or the emotional experience of his previous English learning and the emergent EMI teaching contexts. The study highlights the primacy of reconstructing teacher identities and supporting teacher emotional experiences in EMI teacher training and education programs.