bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracorporeal Membrane Oxygenation for Pertussis: Predictors of Outcome Including Pulmonary Hypertension and Leukodepletion
Authors: Domico Michele , Ridout Deborah , MacLaren Graeme , Barbaro Ryan , Annich Gail , Schlapbach Luregn J. , Brown Katherine L. 
Published: January 2018

Objective:
The recent increase of pertussis cases worldwide has generated questions regarding the utility of extracorporeal membrane oxygenation for children with pertussis. We aimed to evaluate factors associated with extracorporeal membrane oxygenation outcome.

Design:
The study was designed in two parts: a retrospective analysis of the Extracorporeal Life Support Organization Registry to identify factors independently linked to outcome, and an expanded dataset from individual institutions to examine the association of WBC count, pulmonary hypertension, and leukodepletion with survival.

Setting:
Extracorporeal Life Support Organization Registry database from 2002 though 2015, and contributions from 19 international centers.

Patients:
Two hundred infants from the Extracorporeal Life Support Organization Registry and expanded data on 73 children.

Interventions:
None.

Measurements and Main Results:
Of the 200 infants who received extracorporeal membrane oxygenation for pertussis, only 56 survived (28%). In a multivariable logistic regression analysis, the following variables were independently associated with increased chance of survival: older age (odds ratio, 1.43 [1.03–1.98]; p = 0.034), higher Pao
2/Fio
2 ratio (odds ratio, 1.10 [1.03–1.17]; p = 0.003), and longer intubation time prior to the initiation of extracorporeal membrane oxygenation (odds ratio, 2.10 [1.37–3.22]; p = 0.001). The use of vasoactive medications (odds ratio, 0.33 [0.11–0.99]; p = 0.047), and renal neurologic or infectious complications (odds ratio, 0.21 [0.08–0.56]; p = 0.002) were associated with increased mortality. In the expanded dataset (n =73), leukodepletion was independently associated with increased chance of survival (odds ratio, 3.36 [1.13–11.68]; p = 0.03) while the presence of pulmonary hypertension was adverse (odds ratio, 0.06 [0.01–0.55]; p = 0.01).

Conclusions:
The survival rate for infants with pertussis who received extracorporeal membrane oxygenation support remains poor. Younger age, lower Pao
2/Fio
2 ratio, vasoactive use, pulmonary hypertension, and a rapidly progressive course were associated with increased mortality. Our results suggest that pre–extracorporeal membrane oxygenation leukodepletion may provide a survival advantage.
Which US States Pose the Greatest Threats to Military Readiness and Public Health? Public Health Policy Implications for a Cross-sectional Investigation of Cardiorespiratory Fitness, Body Mass Index, and Injuries Among US Army Recruits
Authors: Bornstein Daniel B. , Grieve George L. , Clennin Morgan N. , McLain Alexander C. , Whitsel Laurie P. , Beets Michael W. , Hauret Keith G. , Jones Bruce H. , Sarzynski Mark A. 
Published: January 2018

Objective:
Many states in the southern region of the United States are recognized for higher rates of obesity, physical inactivity, and chronic disease. These states are therefore recognized for their disproportionate public health burden. The purpose of this study was to investigate state-level distributions of cardiorespiratory fitness, body mass index (BMI), and injuries among US Army recruits in order to determine whether or not certain states may also pose disproportionate threats to military readiness and national security.

Methods:
Sex-specific state-level values for injuries and fitness among 165 584 Army recruits were determined. Next, the relationship between median cardiorespiratory fitness and injury incidence at the state level was examined using Spearman correlations. Finally, multivariable Poisson regression models stratified by sex examined state-level associations between fitness and injury incidence, while controlling for BMI, and other covariates.

Main Outcome Measures:
Cardiorespiratory fitness and training-related injury incidence.

Results:
A cluster of 10 states from the south and southeastern regions (Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, and Texas) produced male or female recruits who were significantly less fit and/or more likely to become injured than recruits from other US states. Compared with the “most fit states,” the incidence of injuries increased by 22% (95% CI, 17-28; P < .001) and 28% (95% CI, 19-36; P < .001) in male and female recruits from the “least fit states,” respectively.

Conclusions:
The impact of policies, systems, and environments on physical activity behavior, and subsequently fitness and health, has been clearly established. Advocacy efforts aimed at active living policies, systems, and environmental changes to improve population health often fail. However, advocating for active living policies to improve national security may prove more promising, particularly with legislators. Results from this study demonstrate how certain states, previously identified for their disproportionate public health burden, are also disproportionately burdensome for military readiness and national security.
An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders
Authors: Reuber Markus , Blackburn Daniel J. , Elsey Chris , Wakefield Sarah , Ardern Kerry A. , Harkness Kirsty , Venneri Annalena , Jones Danielle , Shaw Chloe , Drew Paul 
Published: January 2018

Objective:
Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behavior of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with functional memory disorder (FMD).

Methods:
In part 1 of this study, a diagnostic scoring aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features. An optimal cut-off differentiating ND and FMD was established by applying the DSA to 30 initial patient-doctor memory clinic encounters. In part 2, the DSA was tested prospectively in 10 additional cases analyzed independently by 2 conversation analysts blinded to medical information.

Results:
In part 1, the median score of the DSA was +5 in ND and −5 in FMD (P<0.001). The optimal numeric DSA cut-off (+1) identified patients with ND with a sensitivity of 86.7% and a specificity of 100%. In part 2, DSA scores of rater 1 correctly predicted 10/10 and those of rater 2 predicted 9/10 diagnoses.

Conclusions:
This study indicates that interactional and linguistic features can help distinguish between patients developing dementia and those with FMD and could aid the stratification of patients with memory problems.
Emission characteristics and vapour/particulate phase distributions of PCDD/F in a hazardous waste incinerator under transient conditions
Authors: Li Min , Wang Chao , Cen Kefa , Ni Mingjiang , Li Xiaodong 
Published: January 2018

Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/F) emission characteristics and vapour/particulate phase partitions under three continued operation conditions, i.e. shut-down, start-up and after start-up, were investigated by sampling stack gas. The results indicated that the PCDD/F emission levels were 0.40–18.03 ng I-TEQ Nm
−3
, much higher than the annual monitoring level (0.016 ng I-TEQ Nm
−3
). Additionally, the PCDD/F emission levels in start-up were higher than the other two conditions. Furthermore, the PCDD/F congener profiles differed markedly between shut-down and start-up, and the chlorination degree of PCDD/F increased in shut-down and decreased evidently in start-up. Moreover, PCDD/F vapour/particulate phase distributions varied significantly under three transient conditions. The PCDD/F vapour phase proportion decreased as the shut-down process continued, then increased as the start-up process proceeded, finally more than 98% of the PCDD/F congeners were distributed in the vapour phase after start-up. The correlations between log(
C
v
/

C
s

) versus

log

p

L

0

of each PCDD/F congener in stack gas were disorganized in shut-down, and trend to a linear distribution after start-up. Besides, polychlorinated biphenyl emissions show behaviour similar to that of PCDD/F, and the lower chlorinated congeners have a stronger relationship with 2,3,7,8-PCDD/Fs, such as M1CB and D2CB.
DNA extraction from primary liquid blood cultures for bloodstream infection diagnosis using whole genome sequencing
Authors: Anson Luke W. , Chau Kevin , Sanderson Nicholas , Hoosdally Sarah , Bradley Phelim , Iqbal Zamin , Phan Hang , Foster Dona , Oakley Sarah , Morgan Marcus , Peto Tim E. A. ,   Modernizing Medical Microbiology Informatics Group (MMMIG), Crook Derrick W. , Pankhurst Louise J. 
Published: January 2018

Purpose. Speed of bloodstream infection diagnosis is vital to reduce morbidity and mortality. Whole genome sequencing (WGS) performed directly from liquid blood culture could provide single-assay species and antibiotic susceptibility prediction; however, high inhibitor and human cell/DNA concentrations limit pathogen recovery. We develop a method for the preparation of bacterial DNA for WGS-based diagnostics direct from liquid blood culture.

Methodology. We evaluate three commercial DNA extraction kits: BiOstic Bacteraemia, Amplex Hyplex and MolYsis Plus. Differential centrifugation, filtration, selective lysis and solid-phase reversible immobilization bead clean-up are tested to improve human cells/DNA and inhibitor removal. Using WGS (Illumina/MinION), we assess human DNA removal, pathogen recovery, and predict species and antibiotic susceptibility inpositive blood cultures of 44 Gram-negative and 54 Staphylococcus species.

Results/Key findings. BiOstic kit extractions yield the greatest mean DNA concentration, 94–301 ng µl−1, versus 0–2.5 ng µl−1 using Amplex and MolYsis kits. However, we note higher levels of inhibition (260/280 ratio 0.9–2.1) and human DNA (0.0–4.4×106 copies) in BiOstic extracts. Differential centrifugation (2000
g
, 1 min) prior to BiOstic extraction reduces human DNA by 63–89 % with selective lysis minimizing by a further 62 %. Post-extraction bead clean-up lowers inhibition. Overall, 67 % of sequenced samples (Illumina MiSeq) contain <10 % human DNA, with >93 % concordance between WGS-based species and susceptibility predictions and clinical diagnosis. If >60 % of sequencing reads are human (7/98 samples) susceptibility prediction becomes compromised. Novel MinION-based WGS (n=9) currently gives rapid species identification but not susceptibility prediction.

Conclusion. Our method for DNA preparation allows WGS-based diagnosis direct from blood culture bottles, providing species and antibiotic susceptibility prediction in a single assay.
Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice
Authors: Torruella-Suárez María Luisa , Vandenberg Jessica R. , Cogan Elizabeth S. , Tipton Gregory J. , Teklezghi Adonay , Dange Kedar , Patel Gunjan K. , McHenry Jenna A. , Hardaway J. Andrew , Kantak Pranish A. , Crowley Nicole A. , DiBerto Jeffrey F. , Faccidomo Sara P. , Hodge Clyde W. , Stuber Garret D. , McElligott Zoé A. 
Published: January 2018

AbstractThe central nucleus of the amygdala plays a significant role in alcohol use and other affective disorders; however, the genetically-defined neuronal subtypes and their projections that govern these behaviors are not well known. Here we show that neurotensin neurons in the central nucleus of the amygdala of male mice are activated by in vivo ethanol consumption and that genetic ablation of these neurons decreases ethanol consumption and preference in non-ethanol dependent animals. This ablation did not impact preference for sucrose, saccharin, or quinine. We found that the most robust projection of the central amygdala neurotensin neurons was to the parabrachial nucleus, a brain region known to be important in feeding behaviors, conditioned taste aversion, and alarm. Optogenetic stimulation of projections from these neurons to the parabrachial nucleus is reinforcing, and increases ethanol drinking as well as consumption of sucrose and saccharin solutions. These data suggest that this central amygdala to parabrachial nucleus projection influences the expression of reward-related phenotypes and is a novel circuit promoting consumption of ethanol and palatable fluids.
Comparison of two African rice species through a new pan-genomic approach on massive data
Authors: Monat Cécile , Tranchant-Dubreuil Christine , Engelen Stefan , Labadie Karine , Paradis Emmanuel , Tando Ndomassi , Sabot François 
Published: January 2018

AbstractPangenome theory implies that individuals from a given group/species share only a given part of their genome (core-genome), the remaining part being the dispensable one. Domestication process implies a small number of founder individuals, and thus a large core-genome compared to dispensable at the first steps of domestication. We sequenced at high depth 120 cultivated African rice Oryza glaberrima and of 74 wild relatives O. barthii, and mapped them on the external reference from Asian rice O. sativa. We then use a novel DepthOfCoverage approach to identif missing genes. After comparing the two species, we shown that the cultivated species has a smaller core-genome than the wild one, as well as an expected smaller dispensable one. This unexpected output however replaces in perspective the inadequacy of cultivated crops to wilderness.
Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix
Authors: Torres Maria F. , Mathew Lisa S. , Ahmed Ikhlak , Al-Azwani Iman K. , Krueger Robert , Rivera Diego , Mohamoud Yasmin A. , Clark Andrew G. , Suhre Karsten , Malek Joel A. 
Published: January 2018

AbstractThe date palm tree is a commercially important member of the genus Phoenix whose 14 species are all dioecious with separate male and female individuals. Previous studies identified a multi-megabase region of the date palm genome linked to sex and showed that dioecy likely developed in Phoenix prior to speciation. To identify genes critical to sex determination we sequenced the genomes of 28 Phoenix trees representing all 14 species. Male-specific sequences were identified and extended using phased single molecule sequencing or BAC clones to distinguish X and Y alleles.Here we show that only four genes contain sequences conserved in all analyzed males, likely identifying the changes foundational to dioecy in Phoenix. The majority of these sequences show similarity to a single genomic locus in the closely related oil palm. CYP703 and GPAT3, two genes critical to male flower development in other monocots, appear fully deleted in females while maintained as single copy in males. A LOG-like gene appears translocated into the Y chromosome and a cytidine deaminase-like appears at the border of a chromosomal rearrangement. Our data supports a two-mutation model for the evolution from hermaphroditism to dioecy through a gynodioecious intermediate.
Crossover of engagement in groups
Authors: van Mierlo Heleen , Bakker Arnold B. 
Published: January 2018

Purpose
The purpose of this paper is to extend the current knowledge on psychological contagion and crossover by investigating the crossover of task-specific engagement (a positive, fulfilling state of mind) among group members. The paper also examines whether this crossover process is reinforced by strong group cohesion or by higher a priori levels of task engagement of the most engaged group member.

Design/methodology/approach
The authors operationalized crossover as within-group convergence on individual engagement over time. The authors studied this process in 43 newly formed groups performing a dynamic, interactive building task under controlled laboratory conditions, allowing the authors to observe the crossover process from a “zero” point, before any mutual influences had occurred.

Findings
Group member engagement scores indeed converged over time, supporting the proposed crossover effect of engagement, especially when the most engaged group member was highly engaged at the beginning of the group task. Unexpectedly, the explanatory role of group cohesion was not convincingly supported; the crossover of engagement was no stronger in groups with high cohesion.

Practical implications
These findings show that task-specific engagement is indeed transferred among group members, particularly when the most engaged group member is highly engaged.

Originality/value
Previous studies on psychological contagion and crossover were mainly focused on dyadic relationships and specific emotions or impaired well-being. The findings add to this literature by addressing the crossover of engagement – a more complex, beneficial psychological state – among group members and provide new input for developing and sustaining engagement in and of groups.
Validity of generalized compensation contract for PPP project with consideration of private fair reference depending on concession profit
Authors: Wu Xiaoling , Peng Yichen , Liu Xiaofeng , Zhou Jing 
Published: January 2018

Purpose
The purpose of this paper is to analyze the effects of private investor's fair preference on the governmental compensation mechanism based on the uncertainty of income for the public-private-partnership (PPP) project.

Design/methodology/approach
Based on the governmental dilemma for the compensation of PPP project, a generalized compensation contract is designed by the combination of compensation before the event and compensation after the event. Then the private investor's claimed concession profit is taken as its fair reference point according to the idea of the BO model, and its fair utility function is established by improving the FS model. Thus the master-slave counter measure game is applied to conduct the behavior modeling for the governmental compensation contract design.

Findings
By analyzing the model given in this paper, some conclusions are obtained. First, the governmental optimal compensation contract is fair incentive for the private investor. Second, the private fair preference is not intuitively positive or negative related to the social efficiency of compensation. Only under some given conditions, the correlation will show the consistent effect. Third, the private fair behavior’s impact on the efficiency of compensation will become lower and lower as the social cost of compensation reduces. Fourth, the governmental effective compensation scheme should be carried out based on the different comparison scene of the private claimed portfolio profit and the expected revenue for the project.

Originality/value
This study analyzes the effects of private investor's fair preference on the validity of governmental generalized compensation contract of the PPP project for the first time; and the governmental generalized compensation contract designed in this study is a pioneering and exploratory attempt.
Developing a national standard for midwifery mentorship in Uganda
Authors: Kemp Joy , Bannon Elizabeth M. , Mwanja Mercy Muwema , Tebuseeke Deusdedit 
Published: January 2018

Purpose
The purpose of this paper is to describe the development of a national standard for midwifery mentorship in Uganda, part of a wider project which aimed to develop a model of mentorship for Ugandan midwifery using the principles of action research. It aims to stimulate debate about strengthening the capacity of a health regulatory body, midwifery twinning partnerships and the use of international health volunteer placements.

Design/methodology/approach
Model of mentorship for Ugandan midwifery was a 20-month project implemented by the Royal College of Midwives UK and the Uganda Private Midwives Association. Following a situational analysis, the project was structured around three action reflection cycles, participatory workshops, individual twinning relationships between UK and Ugandan midwives and peer exchange visits. The capacity of the Ugandan Nurses and Midwives Council (UNMC) to develop a standard for midwifery mentorship was assessed. A capacity building programme was then designed and implemented to develop the standard for midwifery mentorship.

Findings
The capacity of UNMC was increased and the standard was developed though has yet to be validated and adopted. However, this intervention may not be replicable as a stand-alone intervention because its success was inextricably linked to the wider programme activities and support structures.

Originality/value
This is the first paper describing midwifery twinning to strengthen the capacity of a regulatory body to develop practice standards.
Characterizing supply chain visibility – a literature review
Authors: Somapa Sirirat , Cools Martine , Dullaert Wout 
Published: January 2018

PurposeThe purpose of this paper is to present a literature review that aims to provide insight into the characteristics and effectiveness of supply chain visibility (SCV), as well as to identify metrics that capture these aspects in business processes.Design/methodology/approachA systematic review of the supply chain literature is conducted to identify the characteristics and the effectiveness of SCV. The synthesis of SCV effectiveness and its metrics are based on the process-oriented approach which relates the effectiveness of SCV to improved business performance.FindingsThis study reveals that the characteristics of SCV can be captured in terms of the accessibility, quality, and usefulness of information. The benefits of SCV are found to extend beyond improvements to operational efficiency of business processes or to the strategic competencies of an organization.Practical implicationsThis study underlines that clear agreements between all players involved in the SC can help to solve problems caused by information completeness (type and amount of information), and unlock the full potential of SCV projects.Originality/valueBy using a process-oriented approach, this review provides a comprehensive explanation of the functions of SCV, as well as its first-order effects, in terms of automational, informational, and transformational characteristics.
Content analysis in SCM research: past uses and future research opportunities
Authors: Mir Saif , Lu Shih-Hao , Cantor David , Hofer Christian 
Published: January 2018

PurposeContent analysis is a methodology that has been used in many academic disciplines as a means to extract quantitative measures from textual information. The purpose of this paper is to document the use of content analysis in the supply chain literature. The authors also discuss opportunities for future research.Design/methodology/approachThe authors conduct a literature review of 13 leading supply chain journals to assess the state of the content analysis-based literature and identify opportunities for future research. Additionally, the authors provide a general schema for and illustration of the use of content analysis.FindingsThe findings suggest that content analysis for quantitative studies and hypothesis testing purposes has rarely been used in the supply chain discipline. The research also suggests that in order to fully realize the potential of content analysis, future content analysis research should conduct more hypothesis testing, employ diverse data sets, utilize state-of-the-art content analysis software programs, and leverage multi-method research designs.Originality/valueThe current research synthesizes the use of content analysis methods in the supply chain domain and promotes the need to capitalize on the advantages offered by this research methodology. The paper also presents several topics for future research that can benefit from the content analysis method.