bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polineuropatía crónica inflamatoria desmielinizante: caso clínico
Authors: Quisnia Amaguaya Maira Alexandra , Calderón Guaraca Prissila Banesa , Mendoza Rivas Rodrigo Jose 
Published: September 2024

Introducción: la Polineuropatía crónica inflamatoria desmielinizante es un raro trastorno autoinmune que afecta al sistema nervioso periférico, el diagnóstico, variabilidad en la evolución y respuesta al tratamiento son desafíos clave. Además, el alto costo de tratamientos y el impacto en la calidad de vida subrayan la importancia de investigar esta condición. Objetivo: analizar el manejo de la patología, incluyendo su descripción, plan de atención y tratamiento, mediante estudio de un caso clínico. Metodología: Caso clínico con revisión bibliográfica tipo descriptivo, retrospectivo, se abordan aspectos como definición, fisiopatología, factores de riesgo, diagnóstico, pronóstico, signos y síntomas. La sistematización del caso incluye motivo de consulta, enfermedad actual, antecedentes, medicamentos, examen físico, laboratorios y desenlace. La discusión destaca influencias holísticas en el desenlace, comparando datos con otras investigaciones para enriquecer el artículo. Resultados: Se considera el caso de un hombre de 41 años con múltiples condiciones médicas preexistentes, incluyendo hipotiroidismo, hipertensión arterial, trombosis venosa profunda y tromboembolismo pulmonar. Ingresa a emergencia con síntomas compatibles con síndrome coronario agudo, pero se descartan signos cardíacos significativos en los estudios. Dada su historia de trastornos previos y una polineuropatía inflamatoria, se sospecha un síndrome multiinflamatorio sistémico relacionado con un posible síndrome de hipercoagulabilidad. Se inicia tratamiento y se realiza una exhaustiva evaluación clínica, destacando la presencia de estenosis de canal medular y evidencia de polineuropatía desmielinizante crónica inflamatoria (CIDP) en estudios complementarios. Conclusiones: La Polineuropatía Desmielinizante Crónica Inflamatoria (CIDP) es un desafío en los trastornos autoinmunes del sistema nervioso periférico, evidenciando complejidades en diagnóstico, evolución y tratamiento. El estudio de un caso clínico subraya la importancia de un enfoque integral que incluye medicamentos, control vital, fisioterapia y seguimiento neurológico. La investigación destaca la necesidad de más estudios y atención especializada para abordar eficazmente la CIDP. Área de estudio general: medicina. Área de estudio específica: cardiología. Tipo de estudio: Casos clínicos.
Trastorno del desarrollo cortical y epilepsia refractaria: reporte de caso
Authors: Cuzco Molina Miriam Guadalupe , Mesa Cano Isabel Cristina , Merchán Coronel María Graciela 
Published: September 2024

Introducción: La epilepsia afecta al desarrollo cortical comprometiendo las funciones mentales superiores, y está asociado a malformaciones del desarrollo la tasa de recurrencia es elevada, las mutaciones somáticas pueden detectarse en alrededor del 30 % de los pacientes con malformación del desarrollo cortical, en el 76% de las epilepsias refractarias se presentan como epilepsias farmacorresistentes. Objetivo: determinar el manejo y terapéutica de trastorno del desarrollo cortical y epilepsia refractaria en un caso clínico, con el fin de establecer elementos novedosos e instructivos de la enfermedad. Metodología: estudio de caso clínico de tipo descriptiva, retrospectivo. La técnica empleada para la recolección de la información del caso fue mediante la revisión de historia clínica y para la descripción de la patología fue mediante la recopilación de artículos extraídos de bases de datos reconocidas como: Scopus, PorQuest, Pubmed, web of science, lilacs. Como criterio de inclusión: artículos publicados en los últimos 5 años, en español e inglés. El proceso ético legal se cumple con la firma del asentimiento. Resultados: Paciente masculino de 6 años de edad, debuta con eventos de características epilépticas a los 5 años, es valorado por medico quien prescribe Valcote y lamotrigina sin embargo las crisis se vuelven refractarias, por lo que se suma clobazan (ubadam) sin mejoría este paciente tiene compromiso con la función cognitiva, conforme pasan los meses paciente sufre deterioro de la función, en la resonancia magnética tiene las heterotopias por lo que el paciente es catalogado como trastorno del desarrollo cortical y epilepsia refractaria, al momento cursa estable sin crisis convulsivas con medicación. Conclusiones: existe una prevalencia elevada de la epilepsia refractaria en pacientes con trastornos del desarrollo cortical, su principal manifestación son las crisis convulsivas y el compromiso neurológico, el diagnóstico incluye la clínica, estudios de imagen, electroencefalograma y detalle genético. Más de la mitad de pacientes requieren 2 o más medicamentos para poder controlar las crisis. El tratamiento puede requerir intervención quirúrgica si no mejora con los fármacos habituales, y la dieta complementaria cetógena es importante en el tratamiento. Área de estudio general: Medicina. Área de estudio específica: Neurología. Tipo de estudio: Casos clínicos / Clinical cases.
Comparison of Causes of Mortality Between Hospitalized Unsheltered Homeless Patients and Non-Homeless Sex and Age-Matched Controls: A Retrospective Case-Control Study
Authors: Smaha Juraj , Falat Jakub , Gažová Andrea , Kužma Martin , Kyselovič Ján , Palkovič Michal , Kuruc Roman , Babál Pavel , Payer Juraj , Jackuliak Peter 
Published: September 2024

ObjectivesRoofless individuals represent the most severe category of homelessness. Their clinical characteristics and mortality patterns in Central and Eastern Europe are little known.MethodsA single-center retrospective case-control study at the internal medicine department in Bratislava, Slovakia was conducted. 5694 mortality records from 2010 to 2023 were screened, and 141 (118 men, 23 women) roofless individuals were identified. Patients were sex- and age-matched, with 141 patients from the cohort of non-homeless deceased patients.ResultsCompared to controls, roofless people had a higher incidence of immobility (p = 0.02) and hypothermia (p &lt; 0.0001) at admission. 83% of the roofless people were men, and 59% of the roofless people died before reaching old age (60+). Homeless men died more often from infectious disease (p = 0.02), pneumonia being the most common one (60%). Men from the control group died more often from liver diseases (p = 0.03). There were no significant differences in the causes of mortality between women.ConclusionThese findings could help to reduce the invisibility of the issue of massive premature mortality amongst homeless populations and roofless individuals, in particular.
Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study
Authors: Naja Khaled , Anwardeen Najeha , Bashraheel Sara S. , Elrayess Mohamed A. 
Published: September 2024

BackgroundSulfonylureas have been a longstanding pharmacotherapy in the management of type 2 diabetes, with potential benefits beyond glycemic control. Although sulfonylureas are effective, interindividual variability exists in drug response. Pharmacometabolomics is a potent method for elucidating variations in individual drug response. Identifying unique metabolites associated with treatment response can improve our ability to predict outcomes and optimize treatment strategies for individual patients. Our objective is to identify metabolic signatures associated with good and poor response to sulfonylureas, which could enhance our capability to anticipate treatment outcome.MethodsIn this cross-sectional study, clinical and metabolomics data for 137 patients with type 2 diabetes who are taking sulfonylurea as a monotherapy or a combination therapy were obtained from Qatar Biobank. Patients were empirically categorized according to their glycosylated hemoglobin levels into poor and good responders to sulfonylureas. To examine variations in metabolic signatures between the two distinct groups, we have employed orthogonal partial least squares discriminant analysis and linear models while correcting for demographic confounders and metformin usage.ResultsGood responders showed increased levels of acylcholines, gamma glutamyl amino acids, sphingomyelins, methionine, and a novel metabolite 6-bromotryptophan. Conversely, poor responders showed increased levels of metabolites of glucose metabolism and branched chain amino acid metabolites.ConclusionThe results of this study have the potential to empower our knowledge of variability in patient response to sulfonylureas, and carry significant implications for advancing precision medicine in type 2 diabetes management.
Economic Evaluation of a Novel Lung Cancer Diagnostic in a Population of Patients with a Positive Low-Dose Computed Tomography Result
Authors: Morris Michael J. , Habib Sheila A. , Do Valle Maggie L. , Schneider John E. 
Published: September 2024

Background: Early detection of lung cancer is crucial for improving patient outcomes. Although advances in diagnostic technologies have significantly enhanced the ability to identify lung cancer in earlier stages, there are still limitations. The alarming rate of false positives has resulted in unnecessary utilization of medical resources and increased risk of adverse events from invasive procedures. Consequently, there is a critical need for advanced diagnostics after an initial low-dose computed tomography (LDCT) scan. Objectives: This study evaluated the potential cost savings for US payers of CyPath® Lung, a novel diagnostic tool utilizing flow cytometry and machine learning for the early detection of lung cancer, in patients with positive LDCT scans with indeterminate pulmonary nodules (IPNs) ranging from 6 to 29 mm. Methods: A cost offset model was developed to evaluate the net expected savings associated with the use of CyPath® Lung relative to the current standard of care for individuals whose IPNs range from 6 to 29 mm. Perspectives from both Medicare and private payers in a US setting are included, with a 1-year time horizon. Cost calculations included procedure expenses, complication costs, and diagnostic assessment costs per patient. Primary outcomes of this analysis include cost savings per cohort and cost savings per patient. Results: Our analysis showed positive cost savings from a private payer’s perspective, with expected savings of $895 202 311 per cohort and $6460 per patient, across all patients. Scenario analysis resulted in cost savings of $890 829 889 per cohort, and $6429 per patient. Similarly, savings of $378 689 020 per cohort or $2733 per patient were yielded for Medicare payers, across all patients. In addition, scenario analysis accounting for false negative patients from a Medicare payer perspective yielded savings of $376 902 203 per cohort and $2720 per patient. Discussion: The results suggest substantial cost savings, primarily due to reductions in follow-up diagnostic assessments and procedures, and highlight the importance of accurate diagnostic tools in reducing unnecessary healthcare expenditures. Conclusion: CyPath® Lung utilization yields savings for private and Medicare payers relative to the current standard of care in a US setting for individuals with 6 to 20 mm IPNs.
Aistritheoirí agus aistriúcháin bhundrámaí J. M. Synge
Authors: MURPHY JAMIE 
Published: September 2024

Achoimre
Dírítear aird san alt seo ar na hiarrachtaí is mó atá ar eolas againn i ndáil le bundrámaí Synge a aistriú go Gaeilge. In ainneoin nár scríobh Synge féin drámaí i nGaeilge, bhí tuiscint chuimsitheach aige ar an teanga agus bhí aithne mhaith aige ar an muintir a labhair ó dhúchas í. I ngan fhios do Synge, is é a rinne sé na bunchlocha a leagan síos do na haistritheoirí a tháinig ina dhiaidh chun a chuid bundrámaí a aistriú agus an Ghaeilge a athbhronnadh ar na drámaí. Le céad bliain anuas, chuaigh aistritheoirí éagsúla i ngleic le bundrámaí Synge arís is arís eile agus is léiriú é sin ar an tionchar agus ar an oidhreacht a bhí aige ar an teanga trí chéile. Déantar achoimre san alt seo ar na hiarrachtaí sin agus an chaoi ar glacadh leis na haistriúcháin Ghaeilge i ndiaidh bhás Synge.
Keeping a national institution on the stage: Ernest Blythe and the rebuilding of the Abbey Theatre
Authors: FLYNN CIARA 
Published: September 2024

Historians have, for the most part, overlooked the rebuilding of the Abbey Theatre after its 1951 destruction by fire, a neglect that this article sets out to redress. Debates about rebuilding the Abbey had begun before the fire. The conversations that occurred then, conversations in which Ernest Blythe played an active part, are important to understanding what happened in the years after 1951. Having outlined that context, this article examines the pivotal and underappreciated role played by the Abbey’s managing director Ernest Blythe in securing the reconstruction of the new theatre. Blythe’s familiarity with government proved to be a precious asset in the theatre’s reconstruction, a feat achieved amid some of the most arduous economic conditions in the state’s history.
In the fifteen years between the fire and the opening of the new theatre, Blythe liaised with four different governments about the provision of the new theatre. Criticism of the theatre’s work at its place of exile, the Queen’s, frequently made Blythe the focus of personal attack, and he was accused of stifling artistic standards in favour of easy profit. This article identifies the various decisions Blythe made to maintain an agreeable relationship with the government and to emphasise the worth of the national theatre to the Irish state. It also challenges some of the assumptions about Blythe’s tenure at the Abbey and explains the reasoning behind some of his most controversial programming decisions, which, it is argued, he made to maintain government support for the rebuilding of the Abbey Theatre.
A Census of the β Pic Moving Group and Other Nearby Associations with Gaia*
Authors: Luhman K. L. 
Published: September 2024

Abstract
I have used the third data release of the Gaia mission to improve the reliability and completeness of membership samples in the β Pic moving group (BPMG) and other nearby associations with ages of 20–50 Myr (Sco Body, Carina, Columba, χ
1 For, Tuc-Hor, IC 2602, IC 2391, NGC 2547). I find that Carina, Columba, and χ
1 For are physically related and coeval, and that Carina is the closest fringe of a much larger association. Similarly, Tuc-Hor and IC 2602 form a coeval population that is spatially and kinematically continuous. Both results agree with hypotheses from Gagné et al. I have used the new catalogs to study the associations in terms of their initial mass functions, X-ray emission, ages, and circumstellar disks. For instance, using the model for Li depletion from Jeffries et al., I have derived an age of

24.7

−
0.6

+
0.9

Myr for BPMG, which is similar to estimates from previous studies. In addition, I have used infrared photometry from the Wide-field Infrared Survey Explorer to check for excess emission from circumstellar disks among the members of the associations, which has resulted in a dramatic increase in the number of known disks around M stars at ages of 30–50 Myr and a significant improvement in measurements of excess fractions for those spectral types and ages. Most notably, I find that the W3 excess fraction for M0–M6 initially declines with age to a minimum in BPMG (<0.015), increases to a maximum in Carina/Columba/χ
1 For (

0.041

−
0.007

+
0.009

, 34 Myr), and declines again in the oldest two associations (40–50 Myr). The origin of that peak and the nature of the M dwarf disks at >20 Myr are unclear.
The H i Reservoir in Central Spiral Galaxies and the Implied Star Formation Process
∗
Authors: Dou Jing , Peng Yingjie , Gu Qiusheng , Renzini Alvio , Ho Luis C. , Mannucci Filippo , Daddi Emanuele , Zhang Chengpeng , Li Jiaxuan , Shi Yong , Wang Tao , Zhao Dingyi , Lyu Cheqiu , Li Di , Yuan Feng , Maiolino Roberto , Gao Yulong 
Published: September 2024

Abstract
The cold interstellar medium (ISM) as the raw material for star formation is critical to understanding galaxy evolution. It is generally understood that galaxies stop making stars when, in one way or another, they run out of gas. However, here we provide evidence that central spiral galaxies remain rich in atomic gas even if their star formation rate (SFR) and molecular gas fraction have dropped significantly compared to “normal” star-forming galaxies of the same mass. Since H i is sensitive to external processes, here we investigate central spiral galaxies using a combined sample from the Sloan Digital Sky Survey, Arecibo Legacy Fast ALFA survey, and the extended GALEX Arecibo SDSS Survey. After proper incompleteness corrections, we find that the key H i scaling relations for central spirals show significant but regular systematic dependence on stellar mass. At any given stellar mass, the H i gas mass fraction is about constant with changing specific star formation rate (sSFR), which suggests that H i reservoir is ubiquitous in central spirals with any star formation status down to M
* ∼ 109
M
⊙. Together with the tight correlation between the molecular gas mass fraction and sSFR for galaxies across a wide range of different properties, it suggests that the decline of SFR of all central spirals in the local Universe is due to the halt of H2 supply, though there is plenty of H i gas around. These hence provide critical observations of the dramatically different behavior of the cold multiphase ISM, and a key to understand the star formation process and quenching mechanism.
Magnetically Arrested Circumbinary Accretion Flows
Authors: Most Elias R. , Wang 王 Hai-Yang 海洋 
Published: September 2024

Abstract
Binary systems with comparable masses and a surrounding accretion disk can accrete gas through spiral accretion streams penetrating the central cavity formed by tidal interactions. Using three-dimensional Newtonian magnetohydrodynamics simulations, we investigate the possibility of a magnetically arrested accretion flow through the cavity. Rather than solely continuously feeding the binary through spiral accretion streams, the accretion is regulated by the strong magnetic field inside the cavity. Transport of mass and angular momentum onto the binary then proceeds largely periodically in magnetic flux eruption episodes. The ejected flux tubes carry angular momentum outward and away from the binary, inject hot plasma into the disk, and can launch flares. This likely intermittent scenario could have potential implications for the emission signatures of supermassive black hole binaries and shed light onto the role magnetic fields play in the binary’s orbital evolution.
La fin de vie à domicile à La Réunion : rester chez soi à tout prix ?
Authors: Lépori Mélanie , Pennec Sophie 
Published: September 2024

Mourir à domicile à La Réunion est une pratique courante, inscrite dans la conception traditionnelle de la mort comme étape du cycle de vie, surtout pour les personnes âgées. Considéré comme plus à même de maintenir les repères et habitudes, le domicile permettrait d’ancrer la fin de vie dans une vision de la mort « ordinaire », étape finale de la vie. Cet article s’intéresse aux différentes facettes du maintien à domicile en fin de vie. À partir d’une enquête qualitative auprès de proches ayant accompagné une personne en fin de vie et de professionnels et bénévoles investis dans l’accompagnement de la fin de vie à domicile, nous montrons que la fin de vie à domicile à La Réunion s’inscrit dans des logiques « classiques » : valorisation d’une mort entourée dans un environnement familier et familial en continuité de la vie antérieure sans pour autant que le domicile ne protège des aménagements du logement, de l’arrivée d’aidants professionnels et de bouleversements dans les rythmes des personnes accompagnées et surtout de ceux de leurs proches.
Bien-vieillir : réflexions autour d’un dispositif de prévention adaptable
Authors: Picault Anne-Laure , Beauchamps Camille , Blanc Emma , Lopes Johanna , Bailly Nathalie , Pothier Kristell 
Published: September 2024

La prévention est un enjeu déterminant des politiques publiques actuelles. Le dispositif sanitaire et social français, fondé sur une prise en charge réparatrice des risques sociaux, semble comporter certaines limites à la promotion des politiques publiques préventives. Les actions de promotion du « bien-vieillir » ciblent majoritairement les personnes âgées. Cependant, ces actions manquent de cohérence au vu de la littérature scientifique existante mais également au regard du décalage entre ce qui est proposé et les attentes des bénéficiaires eux-mêmes. Cet article dresse les déterminants de la prévention au « bien-vieillir » et propose une réflexion psycho-sociale ainsi que des recommandations pour les interventions futures. Les interventions associant un partenariat, une co-construction, une communication engageante et une approche centrée sur les besoins des individus seraient les plus efficaces ; notamment, parce qu’elles incluent les aspects motivationnels des individus, la participation de bénévoles, des professionnels en santé et des acteurs locaux. Parallèlement, un objectif global serait de déstigmatiser les pratiques ne relevant pas du « bien-vieillir » afin de promouvoir une approche plus compréhensive des pratiques individuelles.
Low Back Pain or Injury Before Collegiate Athletics, a Potential Risk Factor for Noncontact Athletic Injuries
Authors: Harris-Hayes Marcie , Solomon Steven , Lin Sylvia , Prather Heidi , Hunt Devyani , Agarwal Mansi , Bloom Nancy J. , Mills Lauren , Clohisy John C. 
Published: September 2024

Context
Surrounding the predictive value of clinical measurements and assessments for future athletic injury, most researchers have not differentiated between contact and noncontact injuries.

Objectives
We assessed the association between clinical measures and questionnaire data collected before sport participation and the incidence of noncontact lower extremity (LE) injuries among Division III collegiate athletes.

Design
Prospective cohort study.

Setting
University setting, National Collegiate Athletic Association Division III.

Patients or Other Participants
Here, 488 Division III freshmen athletes were recruited to participate in the study during their preseason physical examinations.

Main Outcome Measure(s)
Prospective incidence of noncontact LE injury. Athletes completed questionnaires to collect demographics and musculoskeletal pain history. Clinical tests, performed by trained examiners, included hip provocative tests, visual appraisal of a single-leg squat to identify dynamic knee valgus, and hip range of motion. Injury surveillance for each athlete’s collegiate career was performed. The athletic training department documented each athlete-reported new onset injury and documented the injury location, type, and outcome (days lost, surgery performed). Univariable generalized estimating equation models were used to analyze the relationship between each clinical measure and the first occurrence of noncontact LE injury. An exchangeable correlation structure was used to account for repeated measurements within athletes (right and left limbs).

Results
Of the 488 athletes, 369 athletes (75%) were included in the final analysis. Sixty-nine noncontact LE injuries were reported. Responding yes to, “Have you ever had pain or an injury to your low back?” was associated with an increased risk of noncontact LE, odds ratio = 1.59 (95% confidence interval = 1.03, 2.45; P = .04). No other clinical measures were associated with an increased injury risk.

Conclusions
A history of prior low back pain or injury was associated with an increased risk of sustaining a noncontact LE injury while participating in National Collegiate Athletic Association Division III athletics.