bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortical thickness alterations linked to somatoform and psychological dissociation in functional neurological disorders
Authors: Perez David L. , Matin Nassim , Williams Benjamin , Tanev Kaloyan , Makris Nikos , LaFrance W. Curt , Dickerson Bradford C. 
Published: October 2017

AbstractBackgroundLinks between dissociation and functional neurological disorder (FND)/conversion disorder are well‐established, yet the pathophysiology of dissociation remains poorly understood. This MRI study investigated structural alterations associated with somatoform and psychological dissociation in FND. We hypothesized that multimodal, paralimbic cingulo‐insular regions would relate to the severity of somatoform dissociation in patients with FND.MethodsFreeSurfer cortical thickness and subcortical volumetric analyses were performed in 26 patients with motor FND and 27 matched healthy controls. Patients with high dissociation as measured by the Somatoform Dissociation Questionnaire‐20 (SDQ) or Dissociative Experiences Scale (DES) were compared to controls in stratified analyses. Within‐group analyses were also performed with SDQ and DES scores in patients with FND. All cortical thickness analyses were whole‐brain corrected at the cluster‐wise level.ResultsPatients with FND and high somatoform dissociation (SDQ > 35) showed reduced left caudal anterior cingulate cortex (ACC) cortical thickness compared to controls. In within‐group analyses, SDQ scores inversely correlated with left caudal ACC cortical thickness in patients with FND. Depersonalization/derealization scores positively correlated with right lateral occipital cortical thickness. Both within‐group findings remained statistically significant controlling for trait anxiety/depression, borderline personality disorder and post‐traumatic stress disorder, adverse life events, and motor FND subtypes in post‐hoc analyses.ConclusionUsing complementary between‐group and within‐group analyses, an inverse association between somatoform dissociation and left caudal ACC cortical thickness was observed in patients with FND. A positive relationship was also appreciated between depersonalization/derealization severity and cortical thickness in visual association areas. These findings advance our neuropathobiological understanding of dissociation in FND. Hum Brain Mapp 39:428–439, 2018. © 2017 Wiley Periodicals, Inc.
Retrospective analysis of obstetric and anesthetic management of patients with placenta accreta spectrum disorders
Authors: Riveros‐Perez Efrain , Wood Cristina 
Published: October 2017

AbstractObjectiveTo assess the management and maternal outcomes of placenta accreta spectrum (PAS) disorders.MethodsA retrospective chart review was conducted of patients diagnosed with PAS disorders (placenta creta, increta, or percreta) who were treated at a US tertiary care center between February 1, 2011, and January 31, 2016. Obstetric management, anesthetic management, and maternal outcomes were analyzed.ResultsA total of 43 cases were identified; placenta previa was diagnosed among 33 (77%). Median age was 33 years (range 23–42). Median blood loss was 1500 mL (interquartile range 1000–2500); blood loss was greatest among the 10 patients with placenta percreta (3250 mL, interquartile range 2200–6000). Transfusion of blood products was necessary among 14 (33%) patients, with no difference in frequency according to the degree of placental invasion (P=0.107). Surgical complications occurred among 10 (23%) patients. Overall, 30 (70%) patients received combined spinal–epidural plus general anesthesia, 4 (9%) received only general anesthesia, and 9 (21%) underwent surgery with combined spinal–epidural anesthesia. One patient experienced difficult airway and another experienced accidental dural puncture.ConclusionPlacenta previa and accreta coexist in many patients, leading to substantial bleeding related to the degree of myometrial invasion. An interdisciplinary team approach plus the use of combined spinal–epidural anesthesia, transitioning to general anesthesia, were advisable and safe.
Review and approval of medical devices in China: Changes and reform
Authors: Liu Wenbo , Shi Xinli , Lu Zhong , Wang Lanming , Zhang Kai , Zhang Xingdong 
Published: October 2017

AbstractThe 4th US‐China Joint Workshop on Regulation, Standards and Innovation of Biomaterials was held during the Annual Meeting of the Society for Biomaterials on April 5, 2017 at Minneapolis, MN. This series of joint workshops have become a unique platform for both the US and China to discuss and update what is new in the field of biomaterials and medical devices in terms of regulation, standards and innovation since 2013. China Food and Drug Administration and its affiliated agencies such as Center for Medical Device Evaluation presented at each of the workshop. With the implementation of Regulations for the Supervision and Administration of Medical Devices (Decree of the State Council of the People's Republic of China, No. 650) since June 1, 2014, the regulatory changes and reform for medical devices in China have been hot topics in the workshops. This report captures the key information presented during the workshops, which includes major changes of the Chinese medical device regulation systems, reform of the review and approval system for medical devices in China, and the special procedures of review and approval for innovative medical devices. The market growth of medical devices along with demands for innovative technologies brings the ongoing regulatory changes and reform in China, which will certainly create positive impact on both the development of the Chinese healthcare system and the innovation of medical devices in China. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2093–2100, 2018.
H2‐P, a honokiol derivative, exerts anti‐angiogenesis effects via c‐MYC signaling pathway in glioblastoma
Authors: Wang Ting , Chen Wei , Wu Jialin 
Published: October 2017

AbstractH2‐P, a derivative of honokiol, was first synthesized in our laboratory. Compared with honokiol, H2‐P has even high anti‐tumor activity. In the present study, we evaluated the ability of H2‐P to inhibit the survival rate in four gliomas cell lines. The result showed that H2‐P could significantly inhibit proliferation of gliomas cells in a dose‐dependent manner (IC50U251 = 9.03, IC50SHG‐44 = 10.74, IC50U78 = 19.87, and IC50c6 = 22.56 nM). Furthermore, to determine the mechanism underlying the anti‐gliomas effects of H2‐P, six kinase activities was detected by Z′‐LYTE™ system. The high‐throughput screening shown that effect targets of H2‐P were MEK and VEGFR2. We also studied the inhibition of H2‐P vascular endothelial cells (EA.HY926). The data shown that H2‐P could increase endothelial cells apoptosis rate, while inhibiting endothelial cell proliferation (IC50EA.hy926 = 16.11 nM) and migration. Besides, we investigated anti‐angiogenesis of H2‐P in the rat thoracic aorta rings, chicken chorioallantoic membrane (CAM), and capillary tube formation models. H2‐P showed strong inhibition of angiogenesis. Moreover, we found that H2‐P also could reduce tumor volume in mice significantly (P < 0.01), and downregulate gene expression level of VEGFR2, MEK, and c‐MYC in tumor. These data suggest that H2‐P have an excellent anti‐tumor activity by exerting anti‐angiogenesis effects via c‐MYC signaling pathway in glioblastoma (GBM).
The ICAM‐1 expression level determines the susceptibility of human endothelial cells to simulated microgravity
Authors: Buravkova Ludmila B. , Rudimov Eugene G. , Andreeva Elena R. , Grigoriev Anatoly I. 
Published: October 2017

AbstractMicrogravity is a principal risk factor hampering human cardiovascular regulation during space flights. Endothelial dysfunction associated with the impaired integrity and uniformity of the monolayer represents a potential trigger for vascular damage. We characterized the expression profile of the multi‐step cascade of adhesion molecules (ICAM‐1, VCAM‐1, E‐selectin, VE‐cadherin) in umbilical cord endothelial cells (ECs) after 24 h of exposure to simulated microgravity (SMG), pro‐inflammatory cytokine TNF‐α, and the combination of the two. Random Positioning Machine (RPM)‐mediated SMG was used to mimic microgravity effects. SMG stimulated the expression of E‐selectin, which is known to be involved in slowing leukocyte rolling. Primary ECs displayed heterogeneity with respect to the proportion of ICAM‐1‐positive cells. ECs were divided into two groups: pre‐activated ECs displaying high proportion of ICAM‐1+‐cells (ECs‐1) (greater than 50%) and non‐activated ECs with low proportion of ICAM‐1+‐cells (ECs‐2) (less than 25%). Only non‐activated ECs‐2 responded to SMG by elevating gene transcription and increasing ICAM‐1 and VE‐cadherin expression. This effect was enhanced after cumulative SMG‐TNF‐α exposure. ECs‐1 displayed an unexpected decrease in number of E‐selectin‐ and ICAM‐1‐positive ECs and pronounced up‐regulation of VCAM1 upon activation of inflammation, which was partially abolished by SMG. Thus, non‐activated ECs‐2 are quite resistant to the impacts of microgravity and even exhibited an elevation of the VE‐cadherin gene and protein expression, thus improving the integrity of the endothelial monolayer. Pre‐activation of ECs with inflammatory stimuli may disturb the EC adhesion profile, attenuating its barrier function. These alterations may be among the mechanisms underlying cardiovascular dysregulation in real microgravity conditions.
Ultrasound‐guided polidocanol foam sclerotherapy for treating venous malformations
Authors: Kumar Subhash , Bhavana Kranti , Kumar Sanjeev , Kumar Prem 
Published: October 2017

AbstractAimTo evaluate clinical and imaging outcomes after ultrasound (US)‐guided 3% polidocanol (POL) foam‐sclerotherapy of venous malformations (VMs).MethodsWe retrospectively evaluated consecutive VM cases over 1.5 years, with 6‐month follow‐up. US findings were used to classify VMs into four types depending upon extent of anechoic channels, connections to adjacent veins, and dysmorphism. Single or multiple needles were inserted depending upon lesion size, and used to inject up to 8 mL POL per session, every 2 to 4 weeks. We evaluated reduction in pain and swelling, lesion resolution on imaging, and patient satisfaction.ResultsThere were 15, 24, 9, and 5 patients (total 53) with type I, II, III, and IV VMs, respectively. The average number of sessions was 5.3, 4.3, and 4, and the average amount of POL injected was 14.24 mL, 16.1 mL, and 23.2 mL for type I, II, III VMs, respectively. The number of sessions correlated with lesion volume (P < .0001). Imaging showed good resolution in 4/15, 18/24, 6/9, and 4/5 patients respectively with type I, II, III, and IV VMs. Patient satisfaction was not related to lesion type (P = .1). ROC analyses showed cut‐off values of 4.9 mL lesion volume, three sessions, and 12 mL POL volume for patient satisfaction. At 6 months, 23 patients having pain had significant improvement (P < .00001). Local (n = 30) and chest pain (n = 2) were the only complications.ConclusionsUS‐guided sclerotherapy with 3% POL foam is safe and effective. Lesions with up to 50% anechoic areas had better resolution, without correlation with patient satisfaction.
Locating qualitative studies in dementia on MEDLINE, EMBASE, CINAHL, and PsycINFO: A comparison of search strategies
Authors: Rogers Morwenna , Bethel Alison , Abbott Rebecca 
Published: October 2017

BackgroundQualitative research in dementia improves understanding of the experience of people affected by dementia. Searching databases for qualitative studies is problematic. Qualitative‐specific search strategies might help with locating studies.ObjectiveTo examine the effectiveness (sensitivity and precision) of 5 qualitative strategies on locating qualitative research studies in dementia in 4 major databases (MEDLINE, EMBASE, PsycINFO, and CINAHL).MethodsQualitative dementia studies were checked for inclusion on MEDLINE, EMBASE, PsycINFO, and CINAHL. Five qualitative search strategies (subject headings, simple free‐text terms, complex free‐text terms, and 2 broad‐based strategies) were tested for study retrieval. Specificity, precision and number needed to read were calculated.ResultsTwo hundred fourteen qualitative studies in dementia were included. PsycINFO and CINAHL held the most qualitative studies out the 4 databases studied (N = 171 and 166, respectively) and both held unique records (N = 14 and 7, respectively). The controlled vocabulary strategy in CINAHL returned 96% (N = 192) of studies held; by contrast, controlled vocabulary in PsycINFO returned 7% (N = 13) of studies held. The broad‐based strategies returned more studies (93‐99%) than the other free‐text strategies (22‐82%). Precision ranged from 0.061 to 0.004 resulting in a number needed to read to obtain 1 relevant study ranging from 16 (simple free‐text search in CINAHL) to 239 (broad‐based search in EMBASE).ConclusionQualitative search strategies using 3 broad terms were more sensitive than long complex searches. The controlled vocabulary for qualitative research in CINAHL was particularly effective. Furthermore, results indicate that MEDLINE and EMBASE offer little benefit for locating qualitative dementia research if CINAHL and PSYCINFO are also searched.
Long‐term outcomes of cement in cement technique for revision endoprosthesis surgery
Authors: Bernthal Nicholas M. , Hegde Vishal , Zoller Stephen D. , Park Howard Y. , Ghodasra Jason H. , Johansen Daniel , Eilber Frederick , Eilber Fritz C. , Chandhanayingyong Chandhanarat , Eckardt Jeffrey J. 
Published: October 2017

Background and ObjectiveCemented endoprosthetic reconstruction after resection of primary bone sarcomas has been a standard‐of‐care option for decades. With increased patient survival, the incidence of failed endoprostheses requiring revision surgery has increased. Revision of cemented endoprotheses by cementing into the existing cement mantle (CiC) is technically demanding.MethodsThis is a retrospective review of our endoprosthesis database of 512 consecutive cemented endoprosthetic reconstructions performed for oncologic diagnoses between 1980 and 2014. A total of 54 implants (mean patient age 32 years, range 13‐81) were revised with a CiC technique. Outcomes evaluated were prosthesis survival, revision surgery categorized according to the Henderson Failure Mode Classification, complications, and functional scores.ResultsFifteen‐year Kaplan‐Meier survival rate was 34% for initial revision and 39% for subsequent revision implants. Mean revised Musculoskeletal Tumor Society (MSTS) Score was 27 at latest follow‐up. Infection rate was 2%, 9%, and 13% for primary endoprostheses, initial revisions, and subsequent revisions, respectively. Limb salvage rate was 87%.ConclusionsAt long‐term follow up, endoprostheses revised with the CiC technique showed consistent 15‐year survival from initial (34%) to subsequent (39%) revision. Despite a relatively high failure rate, these results are encouraging and demonstrate that this is a conservative, repeatable technique.
Dispersive micro‐solid‐phase extraction combined with online preconcentration by capillary electrophoresis for the determination of glycopyrrolate stereoisomers in rat plasma
Authors: Liu Yongjing , Yu Lishuang , Zhang Hua , Chen Dawei 
Published: October 2017

AbstractA simple and sensitive analytical method for four isomers of glycopyrrolate in rat plasma was developed using cation‐selective exhaustive injection‐sweeping cyclodextrin‐modified electrokinetic chromatography (CSEI‐Sweeping‐CDEKC) for online enrichment combined with dispersive micro‐solid‐phase extraction pretreatment. The CSEI‐Sweeping‐CDEKC was conducted on an uncoated fused silica capillary (40.2 cm × 75 μm) with an applied voltage of –20 kV. The electrophoretic analysis was carried out in 30 mM phosphate solution at pH 2.0 containing 20 mg/mL sulfated‐β‐cyclodextrin and 5% acetonitrile. Under these optimized conditions, the detection limit for racemic glycopyrrolate was found to be 2.0 ng/mL and this method could increase 495‐fold detection sensitivity compared with the traditional injection method. Additionally, the parameters that affected the extraction efficiency of dispersive micro‐solid‐phase extraction were also examined systematically. The glycopyrrolate isomers in rat plasma samples as low as 0.0625 μg/mL were able to be separated and detected by capillary electrophoresis with the aid of CSEI‐sweeping. The findings of this study show that the dispersive micro‐solid‐phase extraction pretreatment coupled with CSEI‐Sweeping‐CDEKC is a rapid and convenient method for analyzing glycopyrrolate isomers in rat plasma.
Antidiabetic Activity of Ergosterol from Pleurotus Ostreatus in KK‐Ay Mice with Spontaneous Type 2 Diabetes Mellitus
Authors: Xiong Mingrui , Huang Yun , Liu Yajing , Huang Mi , Song Guanjun , Ming Qian , Ma Xinhua , Yang Jie , Deng Shihao , Wen Yanzhang , Shen Jinhua , Liu Qing‐Hua , Zhao Ping , Yang Xinzhou 
Published: October 2017

ScopeThe number of people with diabetes is increasing rapidly in the world. In the present study, the hypoglycemic activity and potential mechanism of ergosterol (ERG), a phytosterol derived from the edible mushroom Pleurotus ostreatus are investigated in vitro and in vivo.Methods and resultsERG is isolated from Pleurotus ostreatus and identified by NMR spectra. The effects of ERG on the glucose uptake, glucose transporter 4 (GLUT4) translocation, GLUT4 expression, and the phosphorylation of AMPK, Akt and PKC in L6 cells are evaluated. ERG enhances glucose uptake and displays a GLUT4 translocation activity with up‐regulating GLUT4 expression and phosphorylation of Akt and PKC in L6 cells. In vivo, antidiabetic activity of ERG is examined. The phosphorylation of Akt and PKC in different tissues from KK‐Ay mice is assessed. ERG significantly improves insulin resistance and blood lipid indices while reducing fasting blood glucose levels and protecting pancreas and liver in the mice. Moreover, the phosphorylation of Akt and PKC is increased in different tissues.ConclusionThe results suggest that ERG may be a potential hypoglycemic agent for the treatment of T2DM with the probable mechanism of stimulating GLUT4 translocation and expression modulated by the PI3K/Akt pathway and PKC pathway.
Shuffled magnetization‐prepared multicontrast rapid gradient‐echo imaging
Authors: Cao Peng , Zhu Xucheng , Tang Shuyu , Leynes Andrew , Jakary Angela , Larson Peder E.Z. 
Published: October 2017

PurposeTo develop a novel acquisition and reconstruction method for magnetization‐prepared 3‐dimensional multicontrast rapid gradient‐echo imaging, using Hankel matrix completion in combination with compressed sensing and parallel imaging.MethodsA random k‐space shuffling strategy was implemented in simulation and in vivo human experiments at 7 T for 3‐dimensional inversion recovery, T2/diffusion preparation, and magnetization transfer imaging. We combined compressed sensing, based on total variation and spatial‐temporal low‐rank regularizations, and parallel imaging with pixel‐wise Hankel matrix completion, allowing the reconstruction of tens of multicontrast 3‐dimensional images from 3‐ or 6‐min scans.ResultsThe simulation result showed that the proposed method can reconstruct signal‐recovery curves in each voxel and was robust for typical in vivo signal‐to‐noise ratio with 16‐times acceleration. In vivo studies achieved 4 to 24 times accelerations for inversion recovery, T2/diffusion preparation, and magnetization transfer imaging. Furthermore, the contrast was improved by resolving pixel‐wise signal‐recovery curves after magnetization preparation.ConclusionsThe proposed method can improve acquisition efficiencies for magnetization‐prepared MRI and tens of multicontrast 3‐dimensional images could be recovered from a single scan. Furthermore, it was robust against noise, applicable for recovering multi‐exponential signals, and did not require any previous knowledge of model parameters. Magn Reson Med 79:62–70, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Nutritional risk factors predict severe acute graft‐versus‐host disease and early mortality in pediatric allogeneic hematopoietic stem cell transplantation
Authors: Kerby Eva H. , Li Yimei , Getz Kelly D. , Smith Elizabeth C. , Smith Laura T. , Bunin Nancy J. , Seif Alix E. 
Published: October 2017

AbstractBackgroundMalnutrition is a pro‐inflammatory state, yet data on nutritional risk factors and development of acute graft‐versus‐host disease (aGVHD) are extremely limited.ProcedureWe conducted a retrospective cohort analysis of pediatric patients up to age 21 years who underwent allogeneic hematopoietic stem cell transplantation (HSCT) at the Children's Hospital of Philadelphia from January 2011 to September 2014 to determine whether malnutrition was associated with development of aGVHD and early mortality. We identified body mass index (BMI) percentile and serum albumin levels as potential markers of malnutrition and defined two composite nutritional risk variables as any of the following: albumin < 2.8 g/dl, weight loss ≥10% from baseline, and low BMI [<25th (NUT25) or <5th percentile (NUT5)]. Nutritional markers and GVHD grade were assessed at baseline, 30, 60, and 90 days post‐HSCT, and patients were censored upon development of GVHD.ResultsBMI <25th or <5th percentile, NUT25, and NUT5 at the beginning of any 30‐day period predicted a three‐ to fourfold risk of developing of severe (grade III–IV) aGVHD in the subsequent 30 days in models adjusted for age, sex, donor source, and degree of human leukocyte antigen matching. Mortality at day 100 was low, but NUT25 risk at baseline conferred an increased risk of death (7.9% vs. 1%, P = 0.035).ConclusionsMalnutrition is a targetable risk factor in pediatric HSCT; prospective trials are needed to investigate this relationship further and identify effective nutritional interventions.
Delivery of care consistent with the psychosocial standards in pediatric cancer: Current practices in the United States
Authors: Scialla Michele A. , Canter Kimberly S. , Chen Fang Fang , Kolb E. Anders , Sandler Eric , Wiener Lori , Kazak Anne E. 
Published: October 2017

AbstractBackgroundWith published evidence‐based Standards for Psychosocial Care for Children with Cancer and their Families, it is important to know the current status of their implementation. This paper presents data on delivery of psychosocial care related to the Standards in the United States.ProcedurePediatric oncologists, psychosocial leaders, and administrators in pediatric oncology from 144 programs completed an online survey. Participants reported on the extent to which psychosocial care consistent with the Standards was implemented and was comprehensive and state of the art. They also reported on specific practices and services for each Standard and the extent to which psychosocial care was integrated into broader medical care.ResultsParticipants indicated that psychosocial care consistent with the Standards was usually or always provided at their center for most of the Standards. However, only half of the oncologists (55.6%) and psychosocial leaders (45.6%) agreed or strongly agreed that their psychosocial care was comprehensive and state of the art. Types of psychosocial care provided included evidence‐based and less established approaches but were most often provided when problems were identified, rather than proactively. The perception of state of the art care was associated with practices indicative of integrated psychosocial care and the extent to which the Standards are currently implemented.ConclusionMany oncologists and psychosocial leaders perceive that the delivery of psychosocial care at their center is consistent with the Standards. However, care is quite variable, with evidence for the value of more integrated models of psychosocial services.