bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clot waveform analysis of prolonged activated partial thromboplastin time in various disorders
Authors: Kadu Apeksha , Shah Ami M. , Goswami Hansa 
Published: September 2024

ABSTRACT

Introduction:
The prolongation in APTT reflects various disorders affecting the blood coagulation system. Automated coagulation analyzers such as ACL TOP, help in evaluating the clotting cascade by displaying clot reaction curves or waveforms. The fibrin formation curve forms S-shaped curve showing the changes in the absorbance on X-axis and time in seconds on Y-axis. The clotting data is processed to obtain derivatives.

Materials and Methods:
This observational study analyzed 80 samples including 20 samples from normal healthy individuals as control. The parameters studied were time (secs), height (mAbs), and width (secs) of first derivative (FD), fibrin clot time at ½ height, height (mAbs), and width (secs) of both first and second peaks of second derivative (SD).

Result and Discussion:
Hemophilia (n = 13) that consisted of factor VIII deficiency (n = 11) and factor IX deficiency (n = 2) showed biphasic patterns in both first DC and second DC. Cases with thrombosis (n = 8) showed marked elevation in first DC. Various other disorders (n = 39) that consisted of mainly hepatic dysfunction (n = 24) showed prolongation in fibrin formation, first DC, and second DC peak time.

Conclusion:
The atypical derivative curve analysis helps in determining the interferences in clotting cascade. It gives significant information and provides direction for further testing.
Advanced female urethral adenocarcinoma: A case report
Authors: Sharma Ankitkumar , Kumar P. B. Barani , Muthusamy Rajeshwari K. , Mehta Sangita S. 
Published: September 2024

ABSTRACT
Urethral cancer in females is a rare occurrence. Although initially believed to be derived from skene glands, there is no consensus on the cell of origin. Squamous cell carcinoma is the most common, whereas adenocarcinoma is the least common. We report the case of a 58-years-old lady with a history of voiding lower urinary tract symptoms, later requiring a suprapubic cystostomy for retention. Cystoscopy and biopsy showed prostate-specific antigen (PSA) negative adenocarcinoma and postiron emission computed tomography (PETCT) showing pelvic and inguinal nodal metastasis. The patient underwent neoadjuvant chemotherapy followed by anterior exenteration with pelvic lymphadenectomy and ileal conduit. Final histology showed ypT4 yN1 adenocarcinoma, not otherwise specified.
Expeditious management of an unexpected complication of left renal vein ligation during right retroperitoneoscopic simple nephrectomy: A lesson learned the hard way
Authors: Bhargava Priyank , Sharma Kartik , Singh Mahendra 
Published: September 2024

ABSTRACT
We present a case of inadvertent left renal vein clipping during right retroperitoneoscopic nephrectomy (RPN) and describe its expeditious identification and management. A 13-year-old girl underwent RPN for nonfunctioning kidney due to urolithiasis. During the dissection of the right renal vein, the inferior vena cava (IVC) got lifted off the parietal wall and the left renal vein was mistakenly ligated. Based on a strong intra-operative suspicion, the patient underwent an urgent computed tomography angiography which confirmed the ligation of the left renal vein. The patient was reoperated immediately and an end-to-side anastomosis was performed between the left renal vein and the IVC.
An effective Ayurveda management of Sarvangavata W.S.R. to Guillain–Barre syndrome: A case report
Authors: Aswathy Y. S. , Therokar Sagar , Dahiya Abhijeet , Dharmarajan Prasanth 
Published: September 2024

Abstract
Guillain–Barré syndrome (GBS) is a rare but potentially serious autoimmune disorder affecting the peripheral nervous system, leading to muscle weakness, paralysis, and in severe cases, respiratory failure. Therapies, such as immunoglobulin therapy and plasmapheresis, are considered mainstays of GBS treatment. Ayurveda treatment can potentially offer therapeutic support to GBS patients in enhancing recovery. A 43-year-old male presented to the in-patient department of an Ayurvedic hospital with bilateral weakness in both upper and lower limbs, accompanied by pain in the left thigh and lower back region, as well as tingling sensations in the ring and middle fingers of the right hand. Following a comprehensive evaluation, including clinical assessment, neurological examination, magnetic resonance imaging, and nerve conduction study, a conclusive diagnosis of GBS was established. Based on the detailed Ayurveda assessment, an Ayurveda diagnosis of Sarvangavata was also made. Upon admission, the patient underwent a comprehensive in-patient treatment regimen spanning 44 days, which included Udwarthana (dry powder massage), Ksharavasti (enema), Sneha Pana (internal administration of medicated oils), Abhyanga (oil massage) and Sweda (sudation therapy), Virechana (therapeutic purgation), Samsarjana Karma (diet for restoring Agni)), Vasti (medicated enema), Shirobasti (medicated oil retention in the head), Pizhichil (oil bath therapy), and Nasya (nasal administration of medicine). Following these intensive therapies, the patient was discharged and continued on Samana Ousadha (palliative medication) for ongoing management of symptoms. The patient was routinely followed up for 6 months with routine clinical assessments and the symptoms gradually improved and consistent recovery was noticed. This case study underscores the promising prospects of integrating Ayurvedic principles and treatments into the management of GBS. However, to substantiate these findings and elucidate the mechanisms through which Ayurvedic therapies operate, further investigation and rigorous clinical trials are warranted.
Ayurveda Approach in the Management of Hypertensive Retinal Hemorrhage: A Case Report
Authors: Prabi Kunneparambil Prakasan , Garg Vandna , Mehar Kapil , Tripathi Ankur , Bavalatti Narayan , Rajagopala Manjusha 
Published: September 2024

Abstract
Hypertensive retinopathy (HR) refers to changes in the retinal microvasculature that occur with elevated blood pressure and are a visible manifestation of vascular damage. A 54-year-old female patient presented with complaints of headache and blurred vision in both eyes over the last year and with a 5-year history of hypertension. On fundus examination, a flame-shaped hemorrhage associated with arteriolar light reflex changes (copper wiring) was observed in the inferior quadrant of the right eye with deflection of veins at the arteriovenous crossing (Salu’s sign). Management was done on an outpatient basis for 1 month, which included oral administration of Avipattikara Churna, Kaishora Guggulu, Brihat Manjishtadi Kwatha, and Saptamrita Lauha. The retinal features of HR underwent complete resolution with the Ayurveda treatment regimen for 26 days. HR-induced retinal hemorrhage can be successfully managed with the Ayurveda treatment approach.
An Exploratory Case–Control Study for Mitochondrial DNA G10398A in Bipolar I Disorder Patients with a Family History of Affective Disorders
Authors: Mishra Rajan , Quraishi Rizwana , Deep Raman , Jain Raka 
Published: September 2024

Background:
The mitochondrial DNA (mtDNA) G10398A polymorphism has been associated with bipolar disorder (BD). It leads to an amino acid substitution within NADH dehydrogenase subunit, thereby altering the mitochondrial complex I function. This exploratory case–control study assesses the association of mtDNA G10398A with the risk of BD and its relationship to clinical variables in Indian patients.

Methods:
Cases met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of BD-I in remission and had a family history of BD or recurrent unipolar disorder in biological relatives. The healthy controls (HC) had no known illness and were screened negative for Family Interview for Genetic Studies. Participants were assessed using Clinical Pro forma, NIMH-Life Chart Method and Alda lithium response scale. The mtDNA G10398A was assessed with real-time polymerase chain reaction using TaqMan assay.

Results:
A total of 82 participants were recruited across cases and controls, with 42 patients (50% with maternal history) and 40 healthy individuals with similar demographic profiles. The mean age of onset was 25.16 (standard deviation [SD] 7.6) years, with illness for 11.59 years (SD: 7.18). Allele A was found in 50% of cases compared to 32.5% HC (odds ratio = 2.08; 95% confidence interval [CI]: 0.85–5.09). Findings remain non-significant for patients with maternal mood disorders (allele A: 38.9%; 21/42). Cases with allele G had significantly higher body mass index (BMI) (P = 0.008) than those with allele A.

Conclusion:
The study adds information on mtDNA 10398A amongst Indian patient samples and healthy individuals. No significant group difference was found with respect to mtDNA G10398A. The positive association of allele G with higher BMI has potential clinical relevance that can be further investigated in larger samples.
Prevalence, Characteristics and Distribution of Odontogenic Cysts amongst the Indian Subpopulation of Southern Rajasthan: A 5-year Retrospective Study of 218 Cysts
Authors: Khandelwal Pulkit , Rai A. Bhagavandas , Bulgannawar Bipin , Gupta Himanshu , Khan Zibran , Hajira Neha 
Published: September 2024

Background:
Odontogenic cysts (OCs) arise from the odontogenic epithelium and occur in the tooth-bearing regions of the jaws. Proliferation and/or degeneration of this epithelium lead to OC development.

Aim and Objectives:
The purpose of this study was to determine the prevalence, characteristics, distribution and clinicopathological features of OCs and compare with other studies.

Materials and Methods:
Records of OCs were retrieved, and patient’s data, aetiology, clinical features, histopathological distribution, treatment, complications and recurrence were studied.

Results:
A total of 218 OCs were studied in 200 patients. The mean age of patients was 35.74 years. The overall sex ratio (male: female) was 1.22:1. Second, third and fourth decades of life were commonly affected. The majority of the patients (85%) reported with a complaint of pain (with or without swelling). Radicular cyst was the most prevalent type (49.55%). The most common site involved was the anterior maxilla (41.75%). Dental complications such as displacement, mobility, discoloration and root resorption were diagnosed in 91 cysts (41.75%). Bony complications such as expansion and perforation were present in 136 cysts (62.38%). Dentition was non-vital in 61.46% of cysts. The most common treatment method performed was combination surgery (enucleation with or without endodontic treatment/extraction and apicoectomy). Recurrence rate was 3.20%.

Conclusion:
The prevalence, characteristics and distribution features of OCs in India are similar to those of studies conducted in other parts of the world. There is a broad spectrum of OCs, with some cysts having a propensity for certain age, gender and site, whereas a few cysts have distinct properties to recur and have aggressive and invasive behaviour.
Prevalence of Hypertension, Its Risk Factors and 10-year Cardiovascular Disease Risk among Bank Employees in Lagos State, Nigeria
Authors: Ojo Omobola Yetunde , Olasehinde Tolulope , Adeniran Adeyinka , Chieme Chisom Florence , Aderibigbe Adedayo Ayodele 
Published: September 2024

Background:
Hypertension is a significant global public health concern, with unique risk factors affecting those in the banking sector due to their work environment. This study aimed to determine the prevalence of hypertension among bank employees and identify specific contributing risk factors.

Materials and Methods:
A cross-sectional survey of 250 bank employees used pretested structured questionnaires. Various measurements, including body mass index (BMI), blood pressure, lipid profile parameters and cardiovascular events, were recorded. Data were analysed using SPSS software. Categorical variables are presented as frequencies and percentages. Binary logistic regression was employed to identify independent predictors of hypertension (P < 0.05).

Results:
The study participants had a mean age of 37.56 ± 8.98, with 54.5% being female. The majority (98.8%) had tertiary education, and 94.7% resided in urban areas. The prevalence of hypertension was 33.3%. Higher BMI is significantly associated with increased odds of hypertension. For each unit increase in BMI, the odds of having hypertension are approximately 1.98 times higher. Hypertension was also significantly more prevalent in those participants with prior hypertension diagnosis, those with a family history of hypertension, smokers and those who added salt to their food on the table (P < 0.05).

Conclusion:
The alarmingly high prevalence of hypertension underscores the need for targeted intervention and health promotion initiatives. With recognised risk factors, emphasis must be placed on the importance of lifestyle modifications and workplace wellness programmes to mitigate the burden of hypertension.
An extension of the Fukaya–Kato method
Authors: Sharifi Romyar 
Published: September 2024

In a groundbreaking paper, T. Fukaya and K. Kato proved a slight weakening of a conjecture of the author under an assumption that a Kubota–Leopoldt

p

-adic

L

-function has no multiple zeros. This article describes a refinement of their method that sheds light on the role of the

p

-adic

L

-function.
Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire: An observational study
Authors: Jindal Neha , Jena Anuraag , Kumar Krishan , Padhi Bijaya K , Sharma Rajni , Jearth Vaneet , Dutta Usha , Sharma Vishal 
Published: September 2024

BACKGROUND
The gastrointestinal symptom rating scale (GSRS) is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome (IBS) and peptic ulcer disease. This validated scale has questions on around 15 items and has been validated in patients with dyspepsia and IBS.
AIM
To translate and validate the English version of the GSRS questionnaire to the Hindi version.
METHODS
The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian population. The process involved various steps as per the World Health Organization methodology including initial forward translation, backward translation, and assessment by an expert committee. Initial pilot testing was followed by testing in healthy and diseased individuals.
RESULTS
The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls (n = 30, 15 females) and diseased individuals (n = 72, 27 females). The diseased group included patients with functional dyspepsia and IBS. Cronbach's alpha for internal consistency on the final translated GSRS questionnaire was 0.715 which is considered adequate. Twelve questions significantly differentiated the diseased population from the healthy population (P value < 0.05) in the translated Hindi version of the GSRS.
CONCLUSION
The translated Hindi GSRS can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.
COMPARISON OF FASTING BLOOD GLUCOSE LEVELS (BETWEEN GOD-PAP METHOD AND STRIP METHOD) IN DIABETES MELLITUS PATIENTS ATSOKARAJA PUBLIC HEALTH CARE CENTER 1
Authors: Saputri Ririn Indah 
Published: September 2024

ABSTRACT
Diabetes Melitus is a severe chronic disease that occurs when the pancreas does not produce enough insulin (a hormone that regulates blood sugar or glucose), or the boddy cannot effectively use the insulin it produces (WHO, 2016). This was an analytical observasional comparative study to compare the results of fasting blood glucose examination using the GOD-PAP method and the Strip method with a Cross-Sectional study design in patients with Diabetes Melitus at Puskesmas Sokaraja 1. The sample of this study was 56 patients, with the number or patients examined, 28 people. All samples from DM patients has had blood glucose levels more than the normal limit, and the measurement results showed a difference in fasting blood glucose levels with the GOD-PAP method and the Strip method was carried out using the T-Dependent Test, which showed a p-value=0.000 (p<0.05), so it can be concluded that there is a significant comparison of fasting blood glucose levels between the GOD-PAP method and strip method in Diabetes Melitus patients at Sokaraja Health Care Center 1.
Keywords: Fasting blood glucose, GOD-PAP, Strip test

ABSTRAK
Diabetes Melitus merupakan penyakit kronis serius yang terjadi karena pankreas tidak menghasilkan cukup insulin (hormon yang mengatur gula darah atau glukosa), atau ketika tubuh tidak dapat secara efektif menggunakan insulin yang dihasilkan (WHO, 2016). Penelitian ini adalah observasional analitik yang bersifat studi komparatif untuk membandingkan hasil pemeriksaan glukosa darah puasa menggunakan metode GOD-PAP dengan metode strip dengan rancangan penelitian menggunakan Cross Sectional. Tujuan penelitian ini yaitu untuk mengetahui perbandingan hasil pemeriksaan kadar glukosa darah puasa metode GOD-PAP dengan metode strip pada penderita Diabetes Melitus di Puskesmas Sokaraja 1. Sampel penelitian ini berjumlah 56 dengan jumlah yang diperiksa adalah 28 pasien. Seluruh sampel dari pasien DM memiliki kadar glukosa darah lebih dari batas normal dan hasil pengukuran menunjukkan selisih kadar glukosa darah puasa metode GOD-PAP dengan metode strip sebesar 84,75 mg/dL. Penentuan perbandingan kadar glukosa darah puasa metode GOD-PAP dan metode strip dilakukan dengan menggunakan Uji T-Dependent yang menunjukkan nilai p=0.000 (p<0.05), sehingga dapat disimpulkan bahwa terdapat perbandingan yang signifikan pada kadar glukosa darah puasa metode GOD-PAP dengan metode strip pada pasien Diabetes Melitus di Puskesmas Sokaraja 1.
Kata kunci : Glukosa darah puasa, GOD-PAP, Strip tes
GAMBARAN JUMLAH ERITROSIT PADA PASIEN SUSPEK COVID-19 DI RSUD KOTA KENDARI
Authors: Umar Ani , Wenty Darmayanita , Salni Salni 
Published: September 2024

ABSTRACT
Red blood cell or called Erythrocyte is red blood that has the most number of blood cells in the human body. The number of red blood cells can provide information that indicates the presence of hematological disordes. Hematological disorder is interference with the formation of red blood cells, including a decrease and increase in the number of cells (polycythaemia). Reduction in the number of red blood cells is found in chronic diseases, such as: liver disease, anemia, and leukemia, while polycythemia is found in patients with diarrhea, severe dehydration, burns, and heavy bleeding. The purpose of this study was to determine description of erythrocyte amounts in covid-19 suspected patients by using descriptive research, and sampling with total sampling from June -July 2020. The sample of this study was the result of examination of the number of erythrocytes in patients with suspected Covid-19. The results of the study provided a high number of erythrocytes found in patients with suspected Covid-19, as many as 7 patients (26%), the number of erythrocytes in patients with suspected Covid-19 was low, as many as 1 patient (4%), and the normal erythrocytes in patients with suspected Covid-19 was 19 patients (70%).

key words: Erythrocyte, Covid-19, Number of Erythrocytes.

ABSTRAK
Sel darah merah atau disebut juga eritrosit merupakan sel darah yang jumlahnya terbanyak dalam tubuh manusia. Jumlah sel darah merah dapat memberikan informasi yang mengindikasikan adanya gangguan sel darah. Gangguan sel darah adalah gangguan pada pembentukan sel darah merah, meliputi penurunan dan peningkatan jumlah sel (polisitemia). Penurunan jumlah sel darah merah ditemukan pada penyakit kronis, seperti penyakit hati, anemia, dan leukemia, sedangkan polisitemia ditemukan pada penderita diare, dehidrasi berat, luka bakar, maupun pendarahan berat. Tujuan penelitian ini untuk mengetahui gambaran jumlah eritrosit pada pasien suspek Covid-19. Jenis penelitian ini adalah deskriptif dan pengambilan sampel dilakukan dengan total sampling yang merupakan data suspek Covid-19 di RSUD Kota kendari pada bulan juni-juli 2020. Sampel penelitian ini adalah data hasil pemeriksaan jumlah eritrosit pasien suspek Covid-19. Hasil penelitian menunjukkan jumlah eritrosit yang tinggi dijumpai pada pasien suspek Covid-19 yaitu 7 pasien (26%), jumlah eritrosit pada pasien suspek Covid-19 yang rendah yaitu 1 pasien (4%), dan jumlah eritrosit yang normal pada pasien suspek Covid-19 yaitu 19 pasien (70%).
Kata Kunci : Eritrosit, Covid-19, Jumlah Eritrosit.
Formulasi dan Uji Antioksidan Sediaan Serum Wajah dari Ekstrak Etanol Daun Binahong Merah (anredera cordifolia (tan.) Steenis) dengan Menggunakan Metode DPPH
Authors: Marzuki Asnah , Dwi Rantisari Thayeb Andi Meinar , Luturdas Kasparina 
Published: September 2024

Daun Binahong Merah (Anredera Cordifolia (Tan.) Steenis) memiliki kandungan metabolit sekunder yang berpotensi sebagai antioksidan yaitu flavonoid, saponin, tanin, vitamin C, alkaloid. Penelitian ini bertujuan untuk mengetahui formulasi dalam bentuk sediaan serum ekstrak daun binahong merah (Anredera Cordifolia (Tan.)(Steenis) yang stabil secara fisik kimia dan dapat berpotensi sebagai aktivitas antioksidan berdasarkan nilai IC50. Metode penelitian ini secara eksperimental menggunakan metode maserasi dengan variasi konsentrasi yaitu F1 (5%); F2 (10%); F3 (15%); dalam pengujian aktivitas antioksidan menggunakan metode DPPH. Hasil evaluasi sediaan serum wajah menyatakan bahwa uji organoleptik diperoleh bentuk cairan sedikit kental, bau khas ekstrak, uji homogenitas diperoleh sediaan yang homogen, uji pH <0.14 , uji viskositas <235, uji daya sebar <038, dan uji iritasi tidak menimbulkan iritasi pada kulit. Uji aktivitas antioksidan menunjukkan bahwa F1 (27,025). F2 (26,846). F3 (24,624). Maka disimpulkan bahwa serum dari ekstrak etanol daun binahong merah (Anredera Cordifolia (Tan.)(Steenis) memiliki kestabilan fisik dan kimia dan berpotensi sangat kuat sebagai antioksidan.
Analisis Break Even Point dan Margin Of Safety Sebagai Salah Satu Alat Perencanaan Laba pada Koffie 09
Authors: Salma Benisha Amanda  , Sihabudin  , Robby Fauji  
Published: September 2024

Profit planning is an important aspect for companies because it allows them to set profit targets to achieve in a certain period. This research aims to investigate the profit planning process, break-even point (BEP), and margin of safety (MOS) at Koffie 09 Karawang. The research method used is a descriptive approach with a quantitative approach. The data used is quantitative data from primary and secondary sources. Data collection techniques involve interviews and documentation. The results of this calculation provide an overview of the minimum sales point that needs to be achieved so that the company does not lose money, as well as providing guidance on the level of sales needed to achieve the set profit target. The findings from this research show that there are variations in achieving the breakeven point each year. In 2020 it was IDR. 575,942,010 or 30,989 Units. In 2021 it is IDR. 575,942,010 or 30,989 Units. In 2022 it will be IDR. 932,318,143 or 45,456 Units. Showing the safety of sales levels, 2020 has a margin of safety of 10%. In 2021 there is a margin of safety of 10%. In 2022 it has a margin of safety of 10%. Koffie 09 must sell 17,997 units or sales of IDR. 1,654,500,000 To achieve the profit planning goal in 2023, adjustments need to be made to the sales revenue target so that it does not cause losses for the company, which is 43.64% or IDR 722,181,857. It is hoped that the results of this research can help companies carry out optimal profit planning through BEP and MOS calculations.