bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDA Approval Summary: Nivolumab in Advanced Renal Cell Carcinoma After Anti-Angiogenic Therapy and Exploratory Predictive Biomarker Analysis
Authors: Xu James Xunhai , Maher V. Ellen , Zhang Lijun , Tang Shenghui , Sridhara Rajeshwari , Ibrahim Amna , Kim Geoffrey , Pazdur Richard 
Published: February 2017

Abstract
On November 23, 2015, the U.S. Food and Drug Administration approved nivolumab (OPDIVO, Bristol-Myers Squibb Company) for patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy. The approval was based on efficacy and safety data demonstrated in an open-label, randomized study of 821 patients with advanced RCC who progressed after at least one anti-angiogenic therapy. Patients were randomized to nivolumab or everolimus and followed for disease progression. The primary end point was overall survival. Subsequent therapies, including everolimus for patients who developed progressive disease on the nivolumab arm, were allowed, but no cross-over was permitted. The median overall survival was 25.0 months on the nivolumab arm and 19.6 months on everolimus arm (hazard ratio: 0.73; 95% confidence interval: 0.60–0.89). The confirmed response rates were 21.5% versus 3.9%; median durations of response were 23.0 versus 13.7 months, and median times to response were 3.0 versus 3.7 months in the nivolumab and everolimus arms, respectively. A statistically significant improvement in progression-free survival was not observed in this trial. The safety profile of nivolumab in renal cell cancer was similar to that in other disease settings. However, the incidence of immune-mediated nephritis appeared to be higher in patients with RCC.
Breast Cancer Risk Analysis by the Use of Hormonal Contraceptives and Age of Menarche
Authors: Dewi Gusti Ayu Triara , Hendrati Lucia Yovita 
Published: February 2017

ABSTRACTThe number of cases of breast cancer is increasing every year and it’s a serious health problem in the world, including in Indonesia. Breast cancer is type of cancer that is most dominant in Indonesia. High estrogen exposure is one of factor that can increase the risk of breast cancer in women. This study was conducted to determine the relationship of estrogen exposure through the use of hormonal contraceptives and age of menarche with breast cancer incidence in women. Type of this study is observational analytic and use case control design. All of women breast cancer patients of Dr. Soetomo Hospital in 2013 were the population of case. All of woman non breast cancer patients who done breast examination at Dr Soetomo Hospital in 2013 were the population of control. The number of respondents in this study were 90 respondents were drawn from population using simple random sampling method. The variables studied were the use of hormonal contraceptives and age of menarche. The results of the analysis used binary logistic regression (α = 5%) indicated that the use of hormonal contraceptives (p = 0,028; OR = 3,266) and age of menarche (p =0,031; OR = 3,492) has an significant correlation with incidence of breast cancer in women at Dr. Soetomo Hospital in 2013. It is expected that the community can be more accurate in determining the duration of hormonal contraception usage and avoid lifestyle can accelerate the occurrence of menarche.Keywords: breast cancer, risk factor, hormonal contraceptives, age of menarche, estrogen
The Correlation of Initial Sputum Smear Positivity on Treatment Failure of Category 1 Therapy for Pulmonary Tuberculosis
Authors: Ayu Puput Dyah , Isfandiari Muhammad Atoillah 
Published: February 2017

ABSTRACTTuberculosis is an infectious disease and is an important public health problem. Based on data from East Java Province Health Department reported that number of tuberculosis patient in Surabaya is the highest in East Java on year 2014. Early identification and good treatment based on the result of sputum identification are the strategy use to control tuberculosis widespread. So that why, microscopic observation to identify acid fast bacilli (AFB) is the fundamental stage to determine recovery treatment. Initial sputum smear positivity is necessary to determine infectious graded. The objectives of the study were to identify of initial sputum smear positivity on treatment failure of category 1 therapy for pulmonary tuberculosis in RS Paru Surabaya year 2011-2014. This study used case control method with quantitative approach. Forty two samples were taken from secondary data. Case group is 21 samples who have treatment failure and control group is 21 successful treatment. Samples were selected by simple random sampling. The chi square correlation showed that highly positive initial smear (p = 0,045; OR = 5,4) have correlated and risk factor to treatment failure on category 1 therapy for pulmonary tuberculosis. The conclusion is patient’s high positive sputum smear initially correlated to treatment failure on category 1 therapy for pulmonary tuberculosis in RS Paru Surabaya year 2011–2014.Keywords: initial sputum smear positivity, treatment failure,, category 1 therapy for pulmonary tuberculosis
The Risk Effect of Primary Dysmenorrhea on Women of Childbearing Age in Ploso Subdistrict of Tambaksari Surabaya
Authors: Ammar Ulya Rohima 
Published: February 2017

ABSTRACTPrimary dysmenorrhea was menstrual pain without any real abnormalities in genitals and could be a sign of reproductive system disorders. Prevalence of primary dysmenorrhea was quite high, but the lack of attention from the medical world, whereas primary dysmenorrhea can lead to decreased productivity and hinder daily activities. This study aimed to analyze the risk factors of primary dysmenorrhea in Ploso subdistrict of Tambaksari Surabaya. The study was an observational analytic cross sectional design. Sampling was done by multistage cluster sampling. Respondents were 80 women of childbearing age 15-35 years old. Based on the results the prevalence of primary dysmenorrhea was at 71.3% . Most of the impact of primary dysmenorrhea that respondents perceived were declining productivity that is equal to 77.2%. Most of respondents not been examined primary dysmenorrhea to the doctor or midwife (84.2%) with the majority reason was respondents think that symptoms of primary dysmenorrhea perceived is reasonable (54.2%) . The highest proportion of respondents characteristics are aged 15-25 years (51.3%), had family history (52.5%), never given birth (60%), duration of menstruation 3-7 days (86%), age of menarche 12-13 years (53.8%), not did exercise (53.8%), had a normal nutritional status (38.8%), and severe stress (25%). The results of the bivariate analysis showed that there was a relationship between age and family history with primary dysmenorrhea, and there was no relationship between the experience of childbirth, length of menstruation, age of menarche, exercise habits, nutritional status, and state of stress with primary dysmenorrhea. The advice is to check primary dysmenorrhea to the doctor or midwife if find symptoms of primary dysmenorrhea to get treatment (psychotherapy or medication therapy), so that respondents could still work or do activities and productivity is not compromised. Keywords : primary dysmenorrhea , menstrual cramps, risk factors, women of childbearing age, reproduction
Rapid Assessment of Third Round of Sub PIN Diphteria at Tambakrejo Village Jombang
Authors: Ummamah Fatikhatul 
Published: February 2017

ABSTRACTThe third round of Sub PIN diphteria in Tambakrejo village has the lowest coverage and did not reach the target at age 2-36 months (61,77%) and age 3-7 years (82,39%). The aim of this study to describe more about implementation of third round of Sub PIN diphteria in November 2013. This study is descriptive research with Cross Sectional study design. Population is all of parents whose children’s ages 2 month to 15 years old when third round of Sub PIN diphteria are conducted in Kelurahan Tambakrejo. Samples on this research are 150 people were taken from two stages, the first stage is specifiying to 30 clusters (RT) and each cluster are taken 5 respondens. The variables examined in this study are immunization status, the reason not joining Sub PIN, source of information, characteristics of the respondents including age, educational level, occupation, number of children, parent’s knowledge and children’s age. The results showed that 26% of respondents did not covered by the third round of Sub PIN diphteria with the most reason is the children are not willing or crying (56,4%). If seen from respondents whose their children did not covered by the Sub PIN can be known most of them got information (92,3%) and characterictic of respondents most of them have age above 30 years old (66,7%), high level of education from SMA (61,5%), do not work (66,7%) with the number of children that they had 2 childs or under it (61,5%),high level of knowledge (76,9%), most of children’s age is 2 months up to 36 months (43,6%) and 7 years old up to 15 years old (43,6%). Concelling anda approach personally is needed by medics to inform about the benefits of Sub PIN and the danger if did not immunization especially to a pent whose child refuse immunized.Keywords : Rapid Assessment, SUB PIN, Diphteria
The Factors that Affect Stroke at Young Age in Brawijaya Hospital Surabaya
Authors: Alchuriyah Siti , Wahjuni Chatarina Umbul 
Published: February 2017

ABSTRACTStroke non-communicable diseases (NCD) with the number of patients continues to increase from year to year, and occurs in young and old age. This study aimed to determine the risk factors that affect the incidence of stroke in young patients in Brawijaya Hospital Surabaya. This study was conducted using case control design with retrospective approach. Data were taken as secondary data from medical records of 2012-2013. Variables included age at onset of stroke, gender, hypertension, obesity, cholesterol levels, and diabetes mellitus. Samples were the whole young stroke patients of <50 years and control sample were of stroke patients ≥50 years of age. Total number of samples was 60. Comparison of cases with controls was 1: 3. Sampling technique control cases was simple random sampling. Analysis was performed using chi- Square test (α = 0.05) for univariate and bivariate. Multivariate analysis was done using logistic regression fold. Most of the samples of ≥ 50 years old were 75%, male 55%, hypertensive 85%, non obesity 53.3%, increased cholesterol levels 58.3%, and DM 53.3%. There were five variables as risk factors, but four factors did not affect the incidence of stroke in young age: sex p = 0,881, hypertension p = 0.987, cholesterol p = 0,403, diabetes mellitus p = 0.236. As the affecting risk factors, obesity p = 0,015, and in multivariate variables obesity p = 0.009 (α < 0.05). In conclusion, obesitas related with risk factors for early age stroke.Keywords: risk factor, stroke, obesity
Psychologically-Inspired Audio-Visual Speech Recognition Using Coarse Speech Recognition and Missing Feature Theory
Authors: Nakadai Kazuhiro ,   Graduate School of Information Science and Engineering, Tokyo Institute of Technology, Koiwa Tomoaki ,   Honda Research Institute Japan Co., Ltd.
Published: February 2017

[abstFig src='/00290001/10.jpg' width='300' text='System architecture of AVSR based on missing feature theory and P-V grouping' ] Audio-visual speech recognition (AVSR) is a promising approach to improving the noise robustness of speech recognition in the real world. For AVSR, the auditory and visual units are the phoneme and viseme, respectively. However, these are often misclassified in the real world because of noisy input. To solve this problem, we propose two psychologically-inspired approaches. One is audio-visual integration based on missing feature theory (MFT) to cope with missing or unreliable audio and visual features for recognition. The other is phoneme and viseme grouping based on coarse-to-fine recognition. Preliminary experiments show that these two approaches are effective for audio-visual speech recognition. Integration based on MFT with an appropriate weight improves the recognition performance by −5 dB. This is the case even in a noisy environment, in which most speech recognition systems do not work properly. Phoneme and viseme grouping further improved the AVSR performance, particularly at a low signal-to-noise ratio.**This work is an extension of our publication “Tomoaki Koiwa et al.: Coarse speech recognition by audio-visual integration based on missing feature theory, IROS 2007, pp.1751-1756, 2007.”
Bird Song Scene Analysis Using a Spatial-Cue-Based Probabilistic Model
Authors: Kojima Ryosuke ,   Graduate School of Information Science and Engineering, Tokyo Institute of Technology, Sugiyama Osamu , Hoshiba Kotaro , Nakadai Kazuhiro , Suzuki Reiji , Taylor Charles E. ,   Department of Systems and Control Engineering, School of Engineering, Tokyo Institute of Technology,   Honda Research Institute Japan Co., Ltd.,   Graduate School of Information Science, Nagoya University,   Department of Ecology and Evolutionary Biology, University of California, Los Angeles (UCLA)
Published: February 2017

[abstFig src='/00290001/22.jpg' width='300' text='Spatial-cue-based probabilistic model' ] This paper addresses bird song scene analysis based on semi-automatic annotation. Research in animal behavior, especially in birds, would be aided by automated or semi-automated systems that can localize sounds, measure their timing, and identify their sources. This is difficult to achieve in real environments, in which several birds at different locations may be singing at the same time. Analysis of recordings from the wild has usually required manual annotation. These annotations may be inaccurate or inconsistent, as they may vary within and between observers. Here we suggest a system that uses automated methods from robot audition, including sound source detection, localization, separation and identification. In robot audition, these technologies are assessed separately, but combining them has often led to poor performance in natural setting. We propose a new Spatial-Cue-Based Probabilistic Model (SCBPM) for their integration focusing on spatial information. A second problem has been that supervised machine learning methods usually require a pre-trained model, which may need a large training set of annotated labels. We have employed a semi-automatic annotation approach, in which a semi-supervised training method is deduced for a new model. This method requires much less pre-annotation. Preliminary experiments with recordings of bird songs from the wild revealed that our system outperformed the identification accuracy of a method based on conventional robot audition.**This paper is an extension of a proceeding of IROS2015.
ANALISIS PENERAPAN AKUNTANSI SYARIAH BERDASARKAN PSAK 102 PADA PEMBIAYAAN MURABAHAH DI BMT SE-KABUPATEN PATI
Authors: Habibah Muzayyidatul , Nikmah Alfu 
Published: February 2017

<p><em>This study aimed to analyze the recognition and measurement, presentation and disclosure of murabaha transaction in accordance with SFAS 102 at BMT Pati regency. It was field research with qualitative approach. Methods of data collection were interviews and documentation. The results of this study indicated that there is BMT recognizing inventories which should not be done because the practice is murabahah not purchase-based murabaha transactions. BMT has been preparing financial statements Balance Sheet, but the value of the loss reserve accounts Murabahah cannot be seen. In profit/ loss reports, costs of murabaha receivables impairment losses cannot be seen because it is not recognized/recorded in the general journal. BMT has revealed matters related to murabaha transactions, including the acquisition cost of murabaha asset; booking appointment in murabaha based on the order as an obligation or not, while the non-commercial financial reports have been prepared for internal purposes of BMT.</em></p>
Analisis Efektivitas Kebijakan Publik Memihak Masyakat Miskin: Studi Kasus Pelaksanaan Program Raskin di Provinsi Jawa Barat pada Tahun 2007
Authors: Hutagaol M. Parulian , Asmara Alla 
Published: February 2017

Studi ini mempunyai tiga tujuan, yaitu (a) menelaah keefektifan pelaksanaan program Raskin pada tahun 2007, (b) mengkaji persepsi RTM mengenai kemungkinan peningkatan harga tebus normatif raskin di masa depan, dan (c) merumuskan rekomendasi kebijakan untuk meningkatkan efektivitas pelaksanaan program Raskin. Studi dilakukan di provinsi Jawa Barat. Hasil studi menunjukkan bahwa pelaksanaan program masih belum begitu efektif. Di semua wilayah desa yang dipelajari, RTM menebus raskin dengan harga yang jauh di atas harga tebus normatifnya (Rp 1/000 per kg). Juga, RTM menerima raskin dalam kuantitas yang jauh lebih sedikit dari kuota normatifnya (10 Kg per RTM per bulan). Para RTM tidak keberatan bila pemerintah menaikkan tebus raskin, asal dua hal berikut dipenuhi oleh pemerintah. Pertama, harga tebus raskin yang baru tersebut adalah harga franco di rumah RTM. Kedua, pemerintah menaikkan kuota RTM 20 Kg per RTM per bulan seperti dulu. Untuk lebih mengefektifkan pelaksaan program Raskin, studi ini merekomendasikan agar pemerintah mengembangkan sistem kendali pelaksanaan program Raskin di tingkat desa, menaikkan harga tebus normatif raskin, dan menaikkan kuota raskin bulanan RTM menjadi 20 Kg per RTM per bulan, serta melibatkan Pemkab/Pemkot dalam menanggung pembiayaan program Raskin.
Analisis Volatilitas Harga Eceran Beberapa Komoditas Pangan Utama dengan Model ARCH/GARCH
Authors: Sumaryanto NFN 
Published: February 2017

Sejak beberapa tahun terakhir ini harga komoditas pangan cenderung semakin tidak stabil. Terkait dengan itu, efektivitas kebijakan stabilisasi harga pangan ditentukan oleh tersedianya informasi yang lengkap dan pemahaman yang lebih baik mengenai volatilitas harga komoditas yang bersangkutan. Penelitian ini ditujukan untuk menganalisis dan memperbandingkan volatilitas harga komoditas pangan utama yaitu beras, gula pasir, terigu, telur, minyak goreng, cabai merah, dan bawang merah di Indonesia dalam periode dua puluh lima tahun terakhir. Hasil penelitian menunjukkan bahwa ragam harga eceran terdeflasi untuk komoditas beras, gula pasir, terigu, cabai merah, dan bawang merah bersifat heteroskedastik sehingga model peramalan yang lebih sesuai adalah ARCH/GARCH. Dengan pendekatan itu terbukti bahwa sejak Reformasi harga eceran beras, tepung terigu, dan gula pasir ternyata lebih volatil. Untuk harga eceran cabai merah maupun bawang merah, perbedaan volatilitas antara periode sebelum dan sesudah Reformasi tidak nyata.
Analisis Keberlanjutan Perkebunan Kakao Rakyat di Kawasan Perbatasan Pulau Sebatik, Kabupaten Nunukan, Provinsi Kalimantan Timur
Authors: Hidayanto M. , S. Supiandi , Yahya S. , Amien L. I. 
Published: February 2017

Pulau Sebatik merupakan salah satu kawasan perbatasan negara antara Indonesia dan Malaysia. Di kawasan perbatasan Pulau Sebatik, tanaman kakao merupakan salah satu komoditas unggulan yang telah dibudidayakan sejak tahun 1980-an. Penelitian ini bertujuan untuk menganalisis status keberlanjutan perkebunan kakao rakyat di kawasan tersebut. Metode analisis yang digunakan adalah Multi Dimensional Scaling (MDS) yang disebut RAP-SEBATIK (Rapid Appraisal for Cocoa on Sebatik Island) yang hasilnya dinyatakan dalam bentuk indeks dan status keberlanjutan. Analisis Leverage dan Monte Carlo digunakan untuk mengetahui atribut-atribut yang sensitif terhadap indeks, dan status keberlanjutan. Hasil penelitian menunjukkan bahwa pada dimensi ekologi statusnya kurang berkelanjutan (46,23%), dimensi ekonomi kurang berkelanjutan (48,58%), dimensi sosial budaya berkelanjutan (75,20%), dimensi infrastruktur dan teknologi kurang berkelanjutan (36.39%) dan dimensi hukum dan kelembagaan kurang berkelanjutan (40,49%). Dari 53 atribut yang dianalisis, terdapat 17 faktor atau atribut yang sensitif terhadap indeks dan status keberlanjutan, sehingga perlu dilakukan upaya perbaikan atau intervensi terhadap atribut-atribut tersebut untuk meningkatkan indeks dan status keberlanjutan.
Analisa Finansial Pendirian Pabrik Pengolahan Kopi
Authors: Hadi Prajogo U. 
Published: February 2017

<p><strong>Abstrak</strong></p><p><br />Mau tidak mau, ekspor. kopi Indonesia harus ditingkatkan karena ia merupakan salah satu komoditi ekspor non-migas penting. Tetapi mutunya masih rendah, sehingga harganya di pasar dunia masih rendah. Membuka kesempatan bagi pengusaha swasta untuk menanamkan modalnya di bidang pengolahan kopi adalah salah satu kemungkinan untuk mengatasi masalah mutu kopi Indonesia. Penelitian ini bertujuan untuk menilai kelayakan finansial investasi di bidang pengolahan kopi oleh swasta berbentuk Perseroan Terbatas berdasarkan kriteria NPV dan IRR. Hasil analisa menunjukkan bahwa investasi tersebut di daerah kopi Boja, Jawa Tengah adalah menguntungkan dengan NPV sebesar Rp. 124,9 juta dan IRR 27 ,I OJo dengan umur proyek 10 tahun. Namun proyek ini sangat sensitif terhadap perubahan harga kopi dan tersedianya bahan baku kopi.</p>
Особливості імунної відповіді на інфекцію Helicobacter рylori у дітей із хронічною гастродуоденальною патологією
Authors: Sorokman T.V. , Popelyuk M.-O.V. , Makarova O.V. 
Published: February 2017

Актуальність. Імунна відповідь макроорганізму є визначальним чинником клінічного прояву патогенних властивостей Н.pylori. Мета дослідження: вивчити імунологічні особливості Н.pylori-асоційованої гастродуоденальної патології в дітей. Матеріали та методи. Під наглядом перебувало 106 дітей віком від 7 до 18 років, які знаходилися на стаціонарному лікуванні в Чернівецькій обласній клінічній лікарні. Наявність Н.pylori підтверджено гістологічним і серологічним методами. Досліджені показники: CD3+, CD4+, CD8+, В-лімфоцити (CD19+), Т-активні лімфоцити, фагоцитарна активність, рівень циркулюючих імунних комплексів (ЦІК), IgA, IgG, IgM, IgE, секреторний IgA. Статистичний аналіз проведено із використанням програм Microsoft Excel-97 та Statgrafics. Результати. Пацієнти розділені на групи відповідно до позитивного (72 особи, 52,8 %) чи негативного (34 особи, 32,1 %) тесту на Н.pylori та характеру ендоскопічних змін слизової оболонки шлунка і дванадцятипалої кишки (ДПК): у 24 дітей діагностовано антральний поверхневий гастрит, у 22 осіб — поширений поверхневий гастрит, у 23 дітей — нодулярний поверхневий гастрит, у 20 — ерозивний гастрит та у 17 осіб — виразку ДПК. Сироваткові антитіла IgG виявляли досить часто як у хворих, так і здорових осіб, антитіла IgA — у дітей із захворюваннями гастродуоденальної зони. У хворих із Н.pylori (+) виявлено зниження вмісту CD3 до 47,9 ± 0,8 %, CD4 — до 38,8 ± 0,6 %. Кількість CD8 у всіх хворих незначно збільшена, а у Н.pylori (+) вірогідно збільшена до 18,5 ± 0,9 % (p < 0,05). Відношення CD4/CD8 вірогідно знижене саме у пацієнтів із Н.pylori (+) — 2,09 ± 0,10, тоді як у дітей групи порівняння — 2,71 ± 0,20 (р < 0,01) та у Н.pylori (–) пацієнтів — 2,38 ± 0,10 (р < 0,05). Показники фагоцитарної здатності та ЦІК у дітей із гастродуоденальною патологією знижені, а рівень IgA підвищений. Найбільш значні зміни показників як гуморальної, так і клітинної ланок імунної системи спостерігалися у хворих на виразку ДПК. Висновки. Хелікобактер­асоційовані захворювання гастродуоденальної ділянки у дітей супроводжуються порушенням протективних механізмів — клітинної, гуморальної та фагоцитарної ланок імунної системи, що є показанням для призначення імунокоригуючої терапії.