bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of flare-ups and impact of garetosmab in adults with fibrodysplasia ossificans progressiva: a post hoc analysis of the randomized, double-blind, placebo-controlled LUMINA-1 trial
Authors: Keen Richard , Dahir Kathryn M , McGinniss Jennifer , Sanchez Robert J , Mellis Scott , Economides Aris N , Di Rocco Maja , Orcel Philippe , Roux Christian , Tabarkiewicz Jacek , Bachiller-Corral Javier , Cheung Angela M , Al Mukaddam Mona , Mohammadi Kusha , Gu Jing , Srinivasan Dushyanth , Trotter Dinko Gonzalez , Eekhoff E Marelise W , Kaplan Frederick S , Pignolo Robert J 
Published: August 2024

Abstract
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disorder, characterized by progressive heterotopic ossification (HO) and painful soft-tissue inflammatory flare-ups. This was a post hoc analysis from a phase 2 (NCT03188666) trial in which adults with FOP received intravenous anti-activin A antibody garetosmab 10 mg/kg or placebo every 4 wk over 28 wk (Period 1), followed by a 28-wk open-label treatment and extension (Periods 2 and 3). Here we describe flare-ups, their relationship to new HO lesions, and the impact of garetosmab on flare-ups. Volume of new HO lesions was measured by CT. Patient-reported flare-ups were defined by any 2 of the following: new onset of pain, swelling, joint stiffness, decrease in movement, or perceived presence of HO. Flare-ups were experienced by 71% (17/24) of placebo-treated patients, 59% (10/17) of whom developed a new HO lesion irrespective of flare-up location; 24% of flare-ups location-matched new HO lesions. Twenty-nine new HO lesions occurred in the placebo cohort by week 28, of which 12 (41%) occurred in the same location as new or ongoing flare-ups. A higher volume of newly formed heterotopic bone (week 28) occurred in placebo-treated patients who had experienced a prior flare-up vs those without (median [Q1:Q3] of 16.6 [12.0:31.1] vs 3.2 cm3). Garetosmab was previously shown to decrease patient-reported flare-up frequency in Period 1; here, garetosmab reduced the median (Q1:Q3) duration of patient-reported flares (15.0 [6.0:82.0] vs 48.0 [15.0:1.00] d) and the severity of flare-ups vs placebo. Frequency of corticosteroid use was numerically reduced in those treated with garetosmab (40.0%) vs placebo (58.3%). In this analysis, 71% of placebo-treated adults with FOP experienced flare-ups over 28 wk, which were associated with an increased volume of newly formed heterotopic bone. Garetosmab reduced the severity and duration of flare-ups, with effects sustained during the entire trial.
Environmental factors affecting phenology and distribution of Tentyria species (Coleoptera: Tenebrionidae) in Doñana National Park (Southern Iberian Peninsula)
Authors: Cárdenas Ana M , Bujalance José Luis , Camacho Agustín 
Published: August 2024

Abstract
This research focuses on the effect of environmental factors on the phenology and distribution of the Tentyria species (Coleoptera: Tenebrionidae) from Doñana National Park (SW Iberian Peninsula). Data are derived from the results of a project carried out 20 years ago, aimed at inventorying the coleopteran of the park. This information provides a framework for comparison with current or future states since the time elapsed is long enough to detect variations. As the classification of Tentyria species is complex and controversial, the first aspect to be addressed was the taxonomical verification of the species. Indeed, they were T. platyceps Steven., T. subcostata Solier., T. bifida Bujalance, Cárdenas, Ferrer and Gallardo, and T. donanensis Bujalance, Cárdenas, Ferrer and Gallardo. Sampling consisted of 2 years of monthly pitfall trapping, encompassing the surface of the park and adjacent areas. Data on adult seasonal activity and spatial distribution of the species were obtained from the specific abundance in each sampling plot. Phenologically, the 4 species were mainly summer species, with unimodal or bimodal curves depending on the species. The distribution of the species was quite uneven: while T. donanensis was ubiquitous, T. subcostata was restricted to the southern coastal area of the park, and T. platyceps and T. bifida were recorded in the northern half, in marshes or inland forests, respectively. Our results also suggest that extreme temperatures may impose major constraints on the spatial distribution of Tentyria species, which could affect Doñana’s biodiversity in the future scenery of thermal rise linked to climate change.
Research on the function of epigenetic regulation in the inflammation of non-alcoholic fatty liver disease
Authors: Sun Lin , Yue Zhensheng , Wang Lin 
Published: August 2024

Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition, characterized by a spectrum that progresses from simple hepatic steatosis to nonalcoholic steatohepatitis, which may eventually lead to cirrhosis and hepatocellular carcinoma. The precise pathogenic mechanisms underlying NAFLD and its related metabolic disturbances remain elusive. Epigenetic modifications, which entail stable transcriptional changes without altering the DNA sequence, are increasingly recognized as pivotal. The principal forms of epigenetic modifications include DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs. These alterations participate in the regulation of hepatic lipid metabolism, insulin resistance, mitochondrial injury, oxidative stress response, and release of inflammatory cytokines, all of which are associated with the onset and progression of NAFLD. This review discussed recent advances in understanding the potential epigenetic regulation of inflammation in NAFLD. Unraveling these epigenetic mechanisms may facilitate the identification of early diagnostic biomarkers and the development of targeted therapeutic strategies for NAFLD.
Global weather map reveals persistent top-of-atmosphere features on the nearest brown dwarfs
Authors: Chen Xueqing , Biller Beth A , Vos Johanna M , Crossfield Ian J M , Mace Gregory N , Hood Callie E , Tan Xianyu , Allers Katelyn N , Martin Emily C , Bubb Emma , Fortney Jonathan J , Morley Caroline V , Hammond Mark 
Published: August 2024

ABSTRACT
Brown dwarfs and planetary-mass companions display rotationally modulated photometric variability, especially those near the L/T transition. This variability is commonly attributed to top-of-atmosphere (TOA) inhomogeneities, with proposed models including patchy thick and thin clouds, planetary-scale jets, or chemical disequilibrium. Surface mapping techniques are powerful tools to probe their atmospheric structures and distinguish between models. One of the most successful methods for stellar surface mapping is Doppler imaging, where the existence of TOA inhomogeneities can be inferred from their varying Doppler shifts across the face of a rotating star. We applied Doppler imaging to the nearest brown dwarf binary WISE 1049AB (also known as Luhman 16AB) using time-resolved, high-resolution spectroscopic observations from Gemini IGRINS, and obtained for the first time H- and K-band simultaneous global weather map for brown dwarfs. Compared to the only previous Doppler map for a brown dwarf in 2014 featuring a predominant mid-latitude cold spot on WISE 1049B and no feature on WISE 1049A, our observations detected persistent spot-like structures on WISE 1049B in the equatorial to mid-latitude regions on two nights, and revealed new polar spots on WISE 1049A. Our results suggest stability of atmospheric features over time-scale of days and possible long-term stable or recurring structures. H- and K-band maps displayed similar structures in and out of CO bands, indicating the cold spots not solely due to chemical hotspots but must involve clouds. Upcoming 30-m extremely large telescopes will enable more sensitive Doppler imaging of dozens of brown dwarfs and even a small number of directly imaged exoplanets.
Biologically inspired heterogeneous learning for accurate, efficient and low-latency neural network
Authors: Wang Bo , Zhang Yuxuan , Li Hongjue , Dou Hongkun , Guo Yuchen , Deng Yue 
Published: August 2024

ABSTRACT
The pursuit of artificial neural networks that mirror the accuracy, efficiency and low latency of biological neural networks remains a cornerstone of artificial intelligence (AI) research. Here, we incorporated recent neuroscientific findings of self-inhibiting autapse and neuron heterogeneity for innovating a spiking neural network (SNN) with enhanced learning and memorizing capacities. A bi-level programming paradigm was formulated to respectively learn neuron-level biophysical variables and network-level synapse weights for nested heterogeneous learning. We successfully demonstrated that our biologically inspired neuron model could reproduce neural statistics at both individual and group levels, contributing to the effective decoding of brain–computer interface data. Furthermore, the heterogeneous SNN showed higher accuracy (1%–10% improvement), superior efficiency (maximal 17.83-fold reduction in energy) and lower latency (maximal 5-fold improvement) in performing several AI tasks. For the first time, we benchmarked SNN for conducting cell type identification from scRNA-seq data. The proposed model correctly identified very rare cell types associated with severe brain diseases where typical SNNs failed.
The activities, competencies and conditions necessary for public-health policy advisers in a Dutch local government setting to contribute to a healthier living environment: a qualitative multiple-case study
Authors: Mourits Kristine , Spitters Hilde , van der Velden Koos , Bekker Marleen , Molleman Gerard 
Published: August 2024

Abstract
The inclusion of health considerations in the design of the physical living environment can contribute to solving wicked health problems, such as obesity and mental health. Such projects demand an integrated approach and strong collaboration between policy domains. At the level of local government, public-health policy advisers can play an important role in this regard. The aim of this study is to explore how public-health policy advisers in the Netherlands deploy cross-border activities to promote a healthy living environment and to identify the organizational dynamics under which they operate. Drawing on the theory of boundary spanning, a qualitative multiple-case study was conducted in three Dutch pioneering local governments, based on a combination of semi-structured interviews and in-depth project analysis. The results indicate that public-health policy advisers engage in a wide range of boundary-spanning activities at the political-administrative, strategic, tactical and operational levels, including participating in spatial-planning processes, understanding the language of the physical domain and providing the right knowledge about health in relation to the environment. Further, this study demonstrates that creating a healthier living environment is the shared responsibility of the entire local government system, thereby calling for leadership, collective accountability, an integrated approach, coordination, and sufficient staffing capacity. Within this context, policy advisers perform guiding, signaling and connecting roles by undertaking a variety of boundary-spanning activities.
Rapid Vacuolar Sorting of the Borate Transporter BOR1 Requires the Adaptor Protein Complex AP-4 in Arabidopsis
Authors: Yoshinari Akira , Shimizu Yutaro , Hosokawa Takuya , Nakano Akihiko , Uemura Tomohiro , Takano Junpei 
Published: August 2024

Abstract
Plants maintain nutrient homeostasis by controlling the activities and abundance of nutrient transporters. In Arabidopsis thaliana, the borate (B) transporter BOR1 plays a role in the efficient translocation of B under low-B conditions. BOR1 undergoes polyubiquitination in the presence of sufficient B and is then transported to the vacuole via multivesicular bodies (MVBs) to prevent B accumulation in tissues at a toxic level. A previous study indicated that BOR1 physically interacts with µ subunits of adaptor protein complexes AP-3 and AP-4, both involved in vacuolar sorting pathways. In this study, we investigated the roles of AP-3 and AP-4 subunits in BOR1 trafficking in Arabidopsis. The lack of AP-3 subunits did not affect either vacuolar sorting or polar localization of BOR1-GFP, whereas the absence of AP-4 subunits resulted in a delay in high-B-induced vacuolar sorting without affecting polar localization. Super-resolution microscopy revealed a rapid sorting of BOR1-GFP into AP-4-positive spots in the trans-Golgi network (TGN) upon high-B supply. These results indicate that AP-4 is involved in sequestration of ubiquitinated BOR1 into a TGN-specific subdomain ‘vacuolar-trafficking zone’, and is required for efficient sorting of MVB and vacuole. Our findings have thus helped elucidate the rapid vacuolar sorting process facilitated by AP-4 in plant nutrient transporters.
A Kinesin-Like Protein, KAC, is Required for Light-Induced and Actin-Based Chloroplast Movement in Marchantia polymorpha
Authors: Yamamoto-Negi Yoshiko , Higa Takeshi , Komatsu Aino , Sasaki Kanta , Ishizaki Kimitsune , Nishihama Ryuichi , Gotoh Eiji , Kohchi Takayuki , Suetsugu Noriyuki 
Published: August 2024

Abstract
Chloroplasts accumulate on the cell surface under weak light conditions to efficiently capture light but avoid strong light to minimize photodamage. The blue light receptor phototropin regulates the chloroplast movement in various plant species. In Arabidopsis thaliana, phototropin mediates the light-induced chloroplast movement and positioning via specialized actin filaments on the chloroplasts, chloroplast-actin filaments. KINESIN-LIKE PROTEIN FOR ACTIN-BASED CHLOROPLAST MOVEMENT (KAC) and CHLOROPLAST UNUSUAL POSITIONING 1 (CHUP1) are pivotal for actin-based chloroplast movement and positioning in land plants. However, the mechanisms by which KAC and CHUP1 regulate chloroplast movement and positioning remain unclear. In this study, we characterized KAC and CHUP1 orthologs in the liverwort Marchantia polymorpha, MpKAC and MpCHUP1, respectively. Their knockout mutants, Mpkacko and Mpchup1ko, impaired the light-induced chloroplast movement. Although Mpchup1ko showed mild chloroplast aggregation, Mpkacko displayed severe chloroplast aggregation, suggesting the greater contribution of MpKAC to the chloroplast anchorage to the plasma membrane. Analysis of the subcellular localization of the functional MpKAC-Citrine indicated that MpKAC-Citrine formed a punctate structure on the plasma membrane. Structure–function analysis of MpKAC revealed that the deletion of the conserved C-terminal domain abrogates its targeting to the plasma membrane and its function. The deletion of the N-terminal motor domain retains the plasma membrane targeting but abrogates the formation of punctate structure and shows a severe defect in the light-induced chloroplast movement. Our findings suggest that the formation of the punctate structure on the plasma membrane of MpKAC is essential for chloroplast movement.
Transcendental idealism and Kant's reconciliation of determinism and libertarianism
Authors: Beizaei Banafsheh 
Published: August 2024

Abstract
Kant famously argues that transcendental idealism allows us to solve the problem of free will. The basic outlines of the solution are as follows: while freedom and determinism are incompatible, we can consistently predicate them of one and the same being if we take the former to be a quality of the human being as it is in itself and the latter a quality of the human being as it appears. In this paper, I look at three different readings of transcendental idealism—the two-object reading, the two-property reading, and the epistemological reading—and argue that none of them—at least in their standard forms—are able to make sense of this solution. I then draw on my alternative, semantic reading of transcendental idealism to propose a new way of understanding Kant's solution.
The anglicization of science in China
Authors: Li Kai , Zheng Xiang , Ni Chaoqun 
Published: August 2024

Abstract
The preeminence of English as the lingua franca in global science has led to English-dominant publication practices, even in non-English-speaking countries. We examine the complex dynamics of language use in scientific publications in China, a major contributor to global scientific output, and the tensions between English and the native language. By analyzing 2,209,987 multilingual publications from 183,457 projects funded by the National Natural Science Foundation of China, we reveal a strong preference for English as the publication language in China, with 66.2% of publications in English versus 33.8% in Chinese. Key projects and natural sciences and engineering projects favor English more; regional projects and social sciences projects use Chinese more. However, English has a growing prevalence over the years across all research fields, project types, and publication venues. There is a negative correlation between the shares of English usage in journals and conference proceedings. We find only a minor overlap between English and Chinese-language publications, indicating unique contributions rather than repetitive content. However, Chinese-language publications are more likely to be similar to English-language publications. For highly similar cross-language publication pairs, the Chinese version tends to be published earlier. The findings underscore the risk of underestimating China’s scientific output by only counting English-language publications. We highlight the importance of creating a comprehensive multilingual database and the significant role of non-English-language research in global scientific discourse.
Keywords: multilingual publishing; scientific communication; language policy; academic multilingualism; bibliometrics; quantitative analysis.
Evaluation of electric field (E) exposure levels and its relationship with the sleep quality of residents around the BTS antennas in Sabzevar, Iran
Authors: Malvandi Hassan , Fallahi Majid , Saghi Mohammad Hossien , Hassanzadeh Nasrin 
Published: August 2024

Abstract
Mobile devices and base transceiver station (BTS) are the main sources of human exposure to radio frequency electromagnetic fields (RF-EMFs). Therefore, the aim of the present study was to evaluate the levels of exposure to RF-EMF in three different time intervals and three different distances from BTS antennas in Sabzevar. Additional goals were to investigate the electric field (E) difference between different microenvironments, between the suburbs and downtown, and evaluating the sleep quality of residents around BTS antennas at different distances. The results showed significant differences between the values of E Avg and E max Avg at different times (T1, T2, and T3), different distances (50, 100, and 300 m) from BTS antennas, and between BTS antennas located in the suburbs and downtown. No significant differences were observed between the values of E Avg and E max Avg in terms of microenvironments. Poor sleep quality (&gt;5) was recorded in the residents around the BTS antennas at different distances, and a significant difference was observed between the sleep quality of the residents at a distance of ˂100 m compared to the residents at a distance of ˃300 m. The recorded levels of E in all places and times were below the human safety limits set by the Iranian National Standardization Organization, the Information and Communication Technologies Authority and the International Commission on Non-Ionizing Radiation Protection, indicating the absence of potential risk due to exposure to E in the study area.
Anti-LGI1 Antibody-Associated Encephalitis Misdiagnosed as Schizophrenia: A Case Report
Authors: Zhang Jin-he , Fu Bing-bing , Wang Wei , Sun Cong-cong , Xu Jin-jie 
Published: August 2024

Abstract
Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated encephalitis is a rare but clinically significant form of autoimmune encephalitis, predominantly affecting middle-aged men. Its heterogeneous clinical presentation often leads to misdiagnosis, commonly as other neurological or psychiatric disorders. This report details the case of a 46-year-old male who initially presented with depressive symptoms, personality changes, and visual hallucinations. Over time, his condition progressed to include memory impairment, disorganized behavior, and seizures. Initially misdiagnosed with schizophrenia, the correct diagnosis of LGI1 antibody-associated encephalitis was eventually established through positive serum and cerebrospinal fluid (CSF) tests for LGI1 antibodies. Neuroimaging findings revealed characteristic bilateral temporal lobe lesions. The patient demonstrated marked improvement following treatment with methylprednisolone and intravenous immunoglobulin, ultimately achieving significant recovery. This case highlights the critical importance of comprehensive antibody testing and neuroimaging in patients presenting with nonspecific psychiatric and neurological symptoms to prevent misdiagnosis and delays in appropriate treatment. The article also reviews the pathogenesis, clinical manifestations, diagnostic approaches, and therapeutic strategies for LGI1 antibody-associated encephalitis, aiming to enhance clinical awareness and optimize patient outcomes.
Refining sleep staging accuracy: transfer learning coupled with scorability models
Authors: Ganglberger Wolfgang , Nasiri Samaneh , Sun Haoqi , Kim Soriul , Shin Chol , Westover M Brandon , Thomas Robert J 
Published: August 2024

Abstract

Study Objectives
This study aimed to (1) improve sleep staging accuracy through transfer learning (TL), to achieve or exceed human inter-expert agreement and (2) introduce a scorability model to assess the quality and trustworthiness of automated sleep staging.

Methods
A deep neural network (base model) was trained on a large multi-site polysomnography (PSG) dataset from the United States. TL was used to calibrate the model to a reduced montage and limited samples from the Korean Genome and Epidemiology Study (KoGES) dataset. Model performance was compared to inter-expert reliability among three human experts. A scorability assessment was developed to predict the agreement between the model and human experts.

Results
Initial sleep staging by the base model showed lower agreement with experts (κ = 0.55) compared to the inter-expert agreement (κ = 0.62). Calibration with 324 randomly sampled training cases matched expert agreement levels. Further targeted sampling improved performance, with models exceeding inter-expert agreement (κ = 0.70). The scorability assessment, combining biosignal quality and model confidence features, predicted model-expert agreement moderately well (R² = 0.42). Recordings with higher scorability scores demonstrated greater model-expert agreement than inter-expert agreement. Even with lower scorability scores, model performance was comparable to inter-expert agreement.

Conclusions
Fine-tuning a pretrained neural network through targeted TL significantly enhances sleep staging performance for an atypical montage, achieving and surpassing human expert agreement levels. The introduction of a scorability assessment provides a robust measure of reliability, ensuring quality control and enhancing the practical application of the system before deployment. This approach marks an important advancement in automated sleep analysis, demonstrating the potential for AI to exceed human performance in clinical settings.