bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in thromboelastography parameters in pregnancy, labor, and the immediate postpartum period
Authors: Shreeve Norman E. , Barry John A. , Deutsch Leah R. , Gomez Keith , Kadir Rezan A. 
Published: May 2016

AbstractObjectiveTo demonstrate changes in clot mechanics during pregnancy, and to determine the effect that delivery has on immediate postpartum thromboelastography parameters.MethodsIn an observational cross‐sectional/longitudinal study, thromboelastography was performed on whole blood aliquots obtained from women carrying singleton pregnancies attending a center in London, UK, between December 2013 and March 2014. Thromboelastography was repeated 6 hours after delivery among patients recruited in the third trimester or labor. Bleeding questionnaires were completed and routine clinical/demographic data obtained.ResultsOverall, 112 women were included. The thromboelastography parameters were significantly correlated with length of pregnancy. From the third trimester to the postpartum period, there was a significant decrease in time until fibrin formation (R value; 5.8 vs 5.0 minutes, P = 0.036) and in time to reach a certain clot strength (amplitude of 20 mm; K value; 1.3 vs 1.1 minutes, P = 0.007). From established labor to after delivery, there was a significant increase in clot lysis at 60 minutes after the maximum amplitude of clot formation (LY60; 1.8% vs 3.1%, P = 0.001).ConclusionThe present study describes a novel finding regarding changes in clot mechanics in late pregnancy/puerperium and supports the concept of using thromboelastography as part of the routine assessments at delivery.
The Mesoproterozoic mantle plume beneath the northern part of the Siberian craton
Authors: Gladkochub D.P. , Donskaya T.V. , Mazukabzov A.M. , Pisarevsky S.A. , Ernst R.E. , Stanevich A.M. 
Published: May 2016

Abstract
The study of the Mesoproterozoic (1473 ± 24 Ma) dolerites of the Olenek uplift of the Siberian craton basement has shown their petrologic and geochemical similarity to typical OIB produced with participation of a mantle plume. The dolerites are characterized by variations in the geochemical composition explained by different degrees of melting of the same source. A conclusion is drawn that the parental melts of the rocks were slightly modified by crustal contamination, as evidenced from their Nd isotope composition (εNd(T) = + 0.6 to − 0.8) and the presence of inherited zircons of four ages (2564, 2111, 2053, and 1865 Ma). Since the Siberian craton in the structure of the Nuna supercontinent (Columbia) was located relatively close to the Baltic continent and the Congo and São Francisco cratons, we assume that the Early Mesoproterozoic mafic intrusions (1500–1470 Ma) of all these cratons belong to the same large igneous province (LIP). The province formation was related to the activity of superplume (or mantle hot field), which supplied mantle matter to the lithosphere basement. The superplume core was probably located beneath the northern part of the Siberian craton, where basites are compositionally most similar to the primary mantle source.
Confirmatory factor analysis of 2 versions of the Brief Pain Inventory in an ambulatory population indicates that sleep interference should be interpreted separately
Authors: Walton David M. , Putos Joseph , Beattie Tyler , MacDermid Joy C. 
Published: May 2016

Abstract

Background
The Brief Pain Inventory (BPI-SF) is a widely-used generic pain interference scale, however its factor structure remains unclear. An expanded 10-item version of the Interference subscale has been proposed, but the additional value of the 3 extra items has not been rigorously evaluated. The purpose of this study was to evaluate and contrast the factorial and concurrent validity of the original 7-item and 10-item versions of the BPI-SF in a large heterogeneous sample of patients with chronic pain.

Methods
Exploratory and confirmatory factor analyses were conducted on independent subsets of the sample, and concurrent correlations with scales capturing similar constructs were evaluated.

Results
Two independent exploratory factor analyses (n = 500 each) supported a single interference factor in both the 7- and 10-item versions, while confirmatory factor analysis (N =1000) suggested that a 2-factor structure (Physical and Affective) provided better fit. A 3-factor model, where sleep interference was the third factor, improved in model fit further. There was no significant difference in model fit between the 7- and 10-item versions. Concurrent associations with measures of general health, pain intensity and pain-related cognitions were all in the anticipated direction and magnitude and were not different by version of the BPI-SF.

Conclusions and implications
The addition of 3 extra items to the original 7-item Interference subscale of the BPI-SF did not improve psychometric properties. The combined results lead us to endorse a 3-factor structure (Physical, Affective, and Sleep Interference) as the more statistically and conceptually sound option.
Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen
Authors: BARRATT JOEL , CHAN DOUGLAS , SANDARADURA INDY , MALIK RICHARD , SPIELMAN DEREK , LEE ROGAN , MARRIOTT DEBORAH , HARKNESS JOHN , ELLIS JOHN , STARK DAMIEN 
Published: May 2016

SUMMARYAngiostrongylus cantonensisis a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis.Rattusrats are definitive hosts ofA. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. Humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. A presumptive diagnosis is often made based on clinical features, a history of mollusc consumption, eosinophilic pleocytosis in cerebral spinal fluid, and advanced imaging such as computed tomography. Serological tests are available for angiostrongyliasis, though many tests are still under development. While there is no treatment consensus, therapy often includes a combination of anthelmintics and corticosteroids. Angiostrongyliasis is relatively rare, but is often associated with morbidity and sometimes mortality. Recent reports suggest the parasites’ range is increasing, leading to fatalities in regions previously consideredAngiostrongylus-free, and sometimes, delayed diagnosis in newly invaded regions. Increased awareness of angiostrongyliasis would facilitate rapid diagnosis and improved clinical outcomes. This paper summarizes knowledge on the parasites’ life cycle, clinical aspects and epidemiology. The molecular biology ofAngiostrongylusspp. is also discussed. Attention is paid to the significance of angiostrongyliasis in Australia, given the recent severe cases reported from the Sydney region.
Taxonomic diversity estimation using rarefaction
Authors: Raup David M. 
Published: May 2016

Benthic ecologists have successfully applied rarefaction techniques to the problem of compensating for the effect of sample size on apparent species diversity (= species richness). The same method can be used in studies of diversity at higher taxonomic levels (families and orders) in the fossil record where samples represent world-wide distributions of species or genera over long periods of geologic time.Application of rarefaction to several large samples of post-Paleozoic echinoids (totaling 7,911 species) confirms the utility of the method. Rarefaction shows that the observed increase in the number of echinoid families since the Paleozoic is real in the sense that it cannot be explained solely by the increase in numbers of preserved species. There has been no statistically significant increase in the number of families since mid-Cretaceous, however. At the order level, echinoid diversity may have been nearly constant since late Triassic or early Jurassic.
Mortality among institutionalised children during the Great Famine in Ireland: bioarchaeological contextualisation of non-adult mortality rates in the Kilkenny Union Workhouse, 1846–1851
Authors: GEBER JONNY 
Published: May 2016

ABSTRACTOver half of all victims of the Great Irish Famine (1845–1852) were children. Many of these deaths took place in the union workhouses: institutions of government poor relief which for many were the last resort in a desperate struggle to survive famine-induced conditions such as starvation and infectious disease. Archaeological excavations of a mass burial ground dating to 1847–1851 at the former workhouse in Kilkenny City have provided the opportunity to undertake a detailed interdisciplinary exploration of non-adult mortality in an Irish workhouse during the height of the Famine.
Street Politics in a Hybrid Regime: The Diffusion of Political Activism in Post-colonial Hong Kong
Authors: Cheng Edmund W. 
Published: May 2016

AbstractThis paper examines the diffusion of activism in post-colonial Hong Kong through the lens of the political regime and eventful analysis. It first reveals the institutional foundations of the hybrid regime that allowed the creation of a nascent movement society. It then explains how the historic 1 July rally in 2003 and a series of critical events since 2006 have led to a shift in scale and the public staging of street politics. A time-series analysis and onsite survey further capture the dynamics that spawned the collective recognition of grievances and reduced participation costs, leading to the Umbrella Movement. While the spontaneous, voluntary and decentralized organizational structure sustained protest momentum, the regime has adopted hybrid strategies to counter-mobilize bottom-up activism. The result is widening contention between the state and civil society and within civil society, or the coexistence of regime instability and regime longevity, a trend that is increasingly common in hybrid regimes encountering mass protests.
Radiofrequency ablation of atrial tachyarrhythmias in adults with tetralogy of Fallot – predictors of success and outcome
Authors: Ezzat Vivienne A. , Ryan Matthew J. , O’Leary Justin , Ariti Cono , Deanfield John , Pandya Bejal , Cullen Shay , Walker Fiona , Khan Fakhar , Abrams Dominic J. , Lambiase Pier D. , Lowe Martin D. 
Published: May 2016

AbstractBackgroundAdults with tetralogy of Fallot experience atrial tachyarrhythmias; however, there are a few data on the outcomes of radiofrequency ablation. We examined the characteristics, outcome, and predictors of recurrence of atrial tachyarrhythmias after radiofrequency ablation in tetralogy of Fallot patients.Methods/resultsRetrospective data were collected from 2004 to 2013. In total, 56 ablations were performed on 37 patients. We identified two matched controls per case: patients with tetralogy of Fallot but no radiofrequency ablation and not known to have atrial tachyarrhythmias. Acute success was 98%. Left atrial arrhythmias increased in frequency over time. The mean follow-up was 41 months; 78% were arrhythmia-free. Number of cardiac surgeries, age, and presence of atrial fibrillation were predictors of recurrence. Lone cavo-tricuspid isthmus-dependent flutter reduced the likelihood of atrial fibrillation. Right and left atria in patients with tetralogy of Fallot were larger in ablated cases than controls. NYHA class was worse in cases and improved after ablation; baseline status predicted death. Of matched non-ablated controls, a number of them had atrial fibrillation. These patients were excluded from the case–control study but analysed separately. Most of them had died during follow-up, whereas of the matched ablated cases all were alive and the majority in sinus rhythm.ConclusionPatients with tetralogy of Fallot and atrial tachyarrhythmias have more dilated atria than those without atrial tachyarrhythmias. Radiofrequency ablation improves functional status. Left atrial ablation is more commonly required with repeat procedures. There is a high prevalence of atrial tachyarrhythmias, particularly atrial fibrillation, in patients with tetralogy of Fallot; early radiofrequency ablation may have a protective effect against this.
Assessment and Treatment of Adult Acute Responses to Traumatic Stress Following Mass Traumatic Events
Authors: Watson Patricia J. , Shalev Arieh Y. 
Published: May 2016

ABSTRACTAssessment and treatment of acute responses to traumatic stress has received much attention since September 11, 2001. This article elucidates principles of early intervention with adults in the immediate (within 48 hours) and early recovery phase (within the first week). The principles have been drawn from research on risk and recover factors, stress and traumatic stress theory, and expert consensus recommendations. The debriefing model is discussed, and principle interventions of psychological first aid, pharmacology, and mass trauma systems are described. This article concludes with brief guidelines for longer-term interventions and recommendations for future research.
Belief in a Just World and Self-Efficacy to Promote Justice in the World Predict Helping Attitudes, but only among Volunteers
Authors: Correia Isabel , Salvado Sara , Alves Helder V. 
Published: May 2016

AbstractPrevious studies have shown that willingness to help particular victims is predicted separately, or in combination, by the belief in a just world (BJW) and self-efficacy to promote justice in the world (SEJW). Our goal was to extend this knowledge by studying general attitudes towards helping and the association between BJW and SEJW in people that do volunteer service, and by comparing the predictive power of two spheres of BJW, personal BJW and general BJW, on helping attitudes. We measured personal BJW, general BJW, SEJW and helping attitudes in two samples (one comprising university students and the other only volunteers). The results differed in the two samples. For volunteers endorsing strong self-efficacy to promote justice in the world, personal BJW was associated positively with helping attitudes (p = .007). For participants endorsing weak self-efficacy to promote justice in the world, personal BJW was not associated with helping attitudes in either sample. General BJW was not associated with helping attitudes in either sample, either independently or in interaction with self-efficacy to promote justice in the world. The theoretical and practical implications of these results are discussed.
Cross-Cultural Invariance of Emotional Skills and Competence Questionnaire between Portugal and Croatia
Authors: Costa Ana , Faria Luísa , Takšić Vladimir 
Published: May 2016

AbstractEmotional intelligence (EI) and its measures have been widespread across several countries and cultures and the need for valid and robust measures that could expand research on international settings is on the current agenda. This study aimed to assess the measurement invariance of a widely used self-report EI measure, Emotional Skills and Competence Questionnaire (ESCQ), in two cultural contexts (Portugal vs. Croatia). The ESCQ, a 42-item self-report EI scale which comprises three dimensions – Perceive and Understand Emotion, Express and Label Emotion and Manage and Regulate Emotion - was administered to 1,188 Portuguese and Croatian secondary students. The results showed that the ESCQ had satisfactory reliability and the three-factor structure was replicated on both country samples. Configural (χ2 = 308.71, df = 220, p < .01; RMSEA = .030, CFI = .956, TLI = .948) and partial metric (Δχ2 = 9.102, Δdf = 10, p = .522; ΔCFI = −.01, ΔRMSEA = .002) and scalar (Δχ2 = 15.290, Δdf = 21, p = .083; ΔCFI = .001, ΔRMSEA = .006) invariances were supported across groups. This EI measure invariance cross-cultural study highlighted cultural particularities related to emotional competence in Portugal and Croatia contexts and contributed to bring awareness to the validity of cross-cultural studies in the emotional abilities field.
Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
Authors: Hall A R , Burke N , Dongworth R K , Kalkhoran S B , Dyson A , Vicencio J M , Dorn G W , Yellon D M , Hausenloy D J 
Published: May 2016

AbstractMitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR). Inhibiting mitochondrial fission can protect the heart against acute ischemia/reperfusion (I/R) injury. However, the role of the mitochondrial fusion proteins, Mfn1 and Mfn2, in the response of the adult heart to acute I/R injury is not clear, and is investigated in this study. To determine the effect of combined Mfn1/Mfn2 ablation on the susceptibility to acute myocardial I/R injury, cardiac-specific ablation of both Mfn1 and Mfn2 (DKO) was initiated in mice aged 4–6 weeks, leading to knockout of both these proteins in 8–10-week-old animals. This resulted in fragmented mitochondria (electron microscopy), decreased mitochondrial respiratory function (respirometry), and impaired myocardial contractile function (echocardiography). In DKO mice subjected to in vivo regional myocardial ischemia (30 min) followed by 24 h reperfusion, myocardial infarct size (IS, expressed as a % of the area-at-risk) was reduced by 46% compared with wild-type (WT) hearts. In addition, mitochondria from DKO animals had decreased MPTP opening susceptibility (assessed by Ca2+-induced mitochondrial swelling), compared with WT hearts. Mfn2 is a key mediator of mitochondrial/SR tethering, and accordingly, the loss of Mfn2 in DKO hearts reduced the number of interactions measured between these organelles (quantified by proximal ligation assay), attenuated mitochondrial calcium overload (Rhod2 confocal microscopy), and decreased reactive oxygen species production (DCF confocal microscopy) in response to acute I/R injury. No differences in isolated mitochondrial ROS emissions (Amplex Red) were detected in response to Ca2+ and Antimycin A, further implicating disruption of mitochondria/SR tethering as the protective mechanism. In summary, despite apparent mitochondrial dysfunction, hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction due to impaired mitochondria/SR tethering.
Microscopic origins of the terahertz carrier relaxation and cooling dynamics in graphene
Authors: Mihnev Momchil T. , Kadi Faris , Divin Charles J. , Winzer Torben , Lee Seunghyun , Liu Che-Hung , Zhong Zhaohui , Berger Claire , de Heer Walt A. , Malic Ermin , Knorr Andreas , Norris Theodore B. 
Published: May 2016

AbstractThe ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier–carrier interactions and carrier–phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments on hot carriers using terahertz spectroscopy and related techniques have interpreted the variety of observed signals within phenomenological frameworks, and sometimes invoke extrinsic effects such as disorder. Here, we present an integrated experimental and theoretical programme, using ultrafast time-resolved terahertz spectroscopy combined with microscopic modelling, to systematically investigate the hot-carrier dynamics in a wide array of graphene samples having varying amounts of disorder and with either high or low doping levels. The theory reproduces the observed dynamics quantitatively without the need to invoke any fitting parameters, phenomenological models or extrinsic effects such as disorder. We demonstrate that the dynamics are dominated by the combined effect of efficient carrier–carrier scattering, which maintains a thermalized carrier distribution, and carrier–optical–phonon scattering, which removes energy from the carrier liquid.
A lateral signalling pathway coordinates shape volatility during cell migration
Authors: Zhang Liang , Luga Valbona , Armitage Sarah K. , Musiol Martin , Won Amy , Yip Christopher M. , Plotnikov Sergey V. , Wrana Jeffrey L. 
Published: May 2016

AbstractCell migration is fundamental for both physiological and pathological processes. Migrating cells usually display high dynamics in morphology, which is orchestrated by an integrative array of signalling pathways. Here we identify a novel pathway, we term lateral signalling, comprised of the planar cell polarity (PCP) protein Pk1 and the RhoGAPs, Arhgap21/23. We show that the Pk1–Arhgap21/23 complex inhibits RhoA, is localized on the non-protrusive lateral membrane cortex and its disruption leads to the disorganization of the actomyosin network and altered focal adhesion dynamics. Pk1-mediated lateral signalling confines protrusive activity and is regulated by Smurf2, an E3 ubiquitin ligase in the PCP pathway. Furthermore, we demonstrate that dynamic interplay between lateral and protrusive signalling generates cyclical fluctuations in cell shape that we quantify here as shape volatility, which strongly correlates with migration speed. These studies uncover a previously unrecognized lateral signalling pathway that coordinates shape volatility during productive cell migration.
Macrofossil evidence for a rapid and severe Cretaceous–Paleogene mass extinction in Antarctica
Authors: Witts James D. , Whittle Rowan J. , Wignall Paul B. , Crame J. Alistair , Francis Jane E. , Newton Robert J. , Bowman Vanessa C. 
Published: May 2016

AbstractDebate continues about the nature of the Cretaceous–Paleogene (K–Pg) mass extinction event. An abrupt crisis triggered by a bolide impact contrasts with ideas of a more gradual extinction involving flood volcanism or climatic changes. Evidence from high latitudes has also been used to suggest that the severity of the extinction decreased from low latitudes towards the poles. Here we present a record of the K–Pg extinction based on extensive assemblages of marine macrofossils (primarily new data from benthic molluscs) from a highly expanded Cretaceous–Paleogene succession: the López de Bertodano Formation of Seymour Island, Antarctica. We show that the extinction was rapid and severe in Antarctica, with no significant biotic decline during the latest Cretaceous, contrary to previous studies. These data are consistent with a catastrophic driver for the extinction, such as bolide impact, rather than a significant contribution from Deccan Traps volcanism during the late Maastrichtian.
A zwitterionic gel electrolyte for efficient solid-state supercapacitors
Authors: Peng Xu , Liu Huili , Yin Qin , Wu Junchi , Chen Pengzuo , Zhang Guangzhao , Liu Guangming , Wu Changzheng , Xie Yi 
Published: May 2016

AbstractGel electrolytes have attracted increasing attention for solid-state supercapacitors. An ideal gel electrolyte usually requires a combination of advantages of high ion migration rate, reasonable mechanical strength and robust water retention ability at the solid state for ensuring excellent work durability. Here we report a zwitterionic gel electrolyte that successfully brings the synergic advantages of robust water retention ability and ion migration channels, manifesting in superior electrochemical performance. When applying the zwitterionic gel electrolyte, our graphene-based solid-state supercapacitor reaches a volume capacitance of 300.8 F cm−3 at 0.8 A cm−3 with a rate capacity of only 14.9% capacitance loss as the current density increases from 0.8 to 20 A cm−3, representing the best value among the previously reported graphene-based solid-state supercapacitors, to the best of our knowledge. We anticipate that zwitterionic gel electrolyte may be developed as a gel electrolyte in solid-state supercapacitors.