bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrophobic Residues near the Bilin Chromophore-Binding Pocket Modulate Spectral Tuning of Insert-Cys Subfamily Cyanobacteriochromes
Authors: Cho Sung Mi , Jeoung Sae Chae , Song Ji-Young , Song Ji-Joon , Park Youn-Il 
Published: January 2017

AbstractCyanobacteriochromes (CBCRs) are a subfamily of phytochrome photoreceptors found exclusively in photosynthetic cyanobacteria. Four CBCRs containing a second Cys in the insert region (insert-Cys) have been identified from the nonheterocystous cyanobacterium Microcoleus B353 (Mbr3854g4 and Mbl3738g2) and the nitrogen fixing, heterocystous cyanobacterium Nostoc punctiforme (NpF2164g3 and NpR1597g2). These insert-Cys CBCRs can sense light in the near-UV to orange range, but key residues responsible for tuning their colour sensitivity have not been reported. In the present study, near-UV/Green (UG) photosensors Mbr3854g4 (UG1) and Mbl3738g2 (UG2) were chosen for further spectroscopic analysis of their spectral sensitivity and tuning. Consistent with most dual-Cys CBCRs, both UGs formed a second thioether linkage to the phycocyanobilin (PCB) chromophore via the insert-Cys. This bond is subject to breakage and relinkage during forward and reverse photoconversions. Variations in residues equivalent to Phe that are in close contact with the PCB chromophore D-ring in canonical red/green CBCRs are responsible for tuning the light absorption peaks of both dark and photoproducts. This is the first time these key residues that govern light absorption in insert-Cys family CBCRs have been identified and characterised.
Silicon availability modifies nutrient use efficiency and content, C:N:P stoichiometry, and productivity of winter wheat (Triticum aestivum L.)
Authors: Neu Silke , Schaller Jörg , Dudel E. Gert 
Published: January 2017

AbstractSilicon (Si) is known as beneficial element for graminaceous plants. The importance of Si for plant functioning of cereals was recently emphasized. However, about the effect of Si availability on biomass production, grain yield, nutrient status and nutrient use efficiency for wheat (Triticum aestivum L.), as one of the most important crop plants worldwide, less is known so far. Consequently, we assessed the effect of a broad range of supply levels of amorphous SiO2 on wheat plant performance. Our results revealed that Si is readily taken up and accumulated basically in aboveground vegetative organs. Carbon (C) and phosphorus (P) status of plants were altered in response to varying Si supply. In bulk straw biomass C concentration decreased with increasing Si supply, while P concentration increased from slight limitation towards optimal nutrition. Thereby, aboveground biomass production increased at low to medium supply levels of silica whereas grain yield increased at medium supply level only. Nutrient use efficiency was improved by Si insofar that biomass production was enhanced at constant nitrogen (N) status of substrate and plants. Consequently, our findings imply fundamental influences of Si on C turnover, P availability and nitrogen use efficiency for wheat as a major staple crop.
SUBRETINAL CELL-BASED THERAPY
Authors: Wilson David J. , Neuringer Martha , Stoddard Jonathan , Renner Lauren M. , Bailey Steven , Lauer Andreas , McGill Trevor J. 
Published: January 2017

Purpose:
To develop a novel surgical approach to provide consistent delivery of cell suspension into the subretinal space without cell leakage into the vitreous.

Methods:
Cell viability was assessed following mock injections to determine the optimal size cannula for delivery of the cells. A pars plana without vitrectomy approach was used to create a subretinal bleb with balanced salt solution using a 41-gauge cannula. GFP-labeled retinal pigment epithelium cells were injected through transretinal (n = 8) and transscleral (n = 16) injection approaches. Optical coherence tomography, fundus photography and autofluorescence, and histological analysis were used to evaluate surgical success.

Results:
The 30-gauge cannula yielded the highest recovery of cells with highest viability. The transretinal approach consistently resulted in transplanted cells in the vitreous, with some cells coming to rest on the inner limiting membrane. Conversely, the transscleral approach resulted in transplantation of cells into the subretinal space in 100% of cases. Histological analysis confirmed these results.

Conclusion:
We have developed a novel surgical approach that resulted in encapsulation of transplanted cells into the subretinal space with a 100% success rate. This approach will provide a useful tool for further cell transplantation study and may provide an approach for clinical application of delivering cells to the subretinal space.
NOVEL CLASSIFICATION SYSTEM FOR COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM
Authors: Dedania Vaidehi S. , Ozgonul Cem , Zacks David N. , Besirli Cagri G. 
Published: January 2017

Purpose:
To develop an anatomical classification scheme for combined hamartoma of the retina and retinal pigment epithelium (RPE) and specify recommendations for follow-up interval.

Methods:
Retrospective review of patients with combined hamartoma of the retina and RPE examined during a 7-year period (2008–2015). The clinical presentation, fundus examination, and optical coherence tomography were analyzed.

Results:
Lesions were classified based on location, fundus features, and optical coherence tomography findings. Lesion location: macular/peripapillary—Zone 1; mid-periphery—Zone 2; and far periphery—Zone 3. Associated fundus findings: no retinal traction—Stage 1; retinal traction and/or retinoschisis—Stage 2; and retinal detachment—Stage 3. Optical coherence tomography findings: epiretinal component only—A; partial retinal involvement—B; and complete retinal and RPE involvement—C. Complete ophthalmologic evaluation is recommended at least every 6 months for patients younger than 12 years, with more frequent follow-up in patients with: lesions in the macula/peripapillary (Zone 1) or with retinal traction, retinoschisis, or retinal detachment (Stage 2 and 3). Surgical intervention is recommended in patients with vision loss secondary to macular traction or retinal detachment.

Conclusion:
A new clinical classification system is proposed for evaluating and managing patients with combined hamartoma of the retina and RPE. The zone and stage of combined hamartoma of the retina and RPE lesion will assist in determining follow-up interval and surgical intervention. Application of a uniform classification scheme will facilitate assessment and comparison of findings across different studies.
Patterns of Care and Outcomes in Cardiovascular Disease After Kidney Transplantation in the United States
Authors: Mathur Amit K. , Chang Yu-Hui , Steidley D. Eric , Heilman Raymond , Khurmi Narjeet , Wasif Nabil , Etzioni David , Moss Adyr A. 
Published: January 2017

Background
Cardiovascular disease (CVD) is an important driver of mortality after kidney transplantation. Its broader impact on posttransplant health care utilization in US hospitals is unknown.

Methods
We used administrative claims data from the Nationwide Inpatient Sample and the American Hospital Association Annual Survey to identify hospitalizations for kidney transplant patients with a cardiovascular diagnosis from 2005 to 2011. CVD hospitalizations were stratified by transplant hospital status to characterize patterns in inpatient health care utilization and outcomes. Based on these analyses, the domestic burden of treatment for posttransplant CVD (myocardial infarction, stroke, congestive heart failure, dysrhythmia, cardiac arrest, malignant hypertension) was estimated.

Results
The total domestic burden of post-kidney transplant hospitalization between 2005 and 2011 is estimated at 389 138 of which 26.5% of episodes were related to CVD (n = 103 118). CVD was responsible for a growing proportion of post-transplant hospitalizations over time (24.4%-30.4%, P < 0.001). Compared with nontransplant hospitals, transplant hospitals had similar length of stay (median length of stay, 3.7 days), higher median costs per hospitalization (US $10 364 vs US $8606, overall US $9324), and lower adjusted mortality (3.2% vs 3.9%, overall 3.6%; P = 0.003).

Conclusions
Inpatient CVD care is increasing over time for kidney transplant patients, accounting for 30% of all post-transplant hospitalizations. Variation exists in the inpatient care, outcomes, and costs between by hospital type. Further studies are needed to better understand the mechanisms behind these phenomena.
Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired
Authors: Blockley Nicholas P. , Harkin James W. , Bulte Daniel P. 
Published: January 2017

AbstractCerebrovascular reactivity mapping (CVR), using magnetic resonance imaging (MRI) and carbon dioxide as a stimulus, provides useful information on how cerebral blood vessels react under stress. This information has proven to be useful in the study of vascular disorders, dementia and healthy ageing. However, clinical adoption of this form of CVR mapping has been hindered by relatively long scan durations of 7 to 12 minutes. By replacing the conventional block presentation of carbon dioxide enriched air with a sinusoidally modulated stimulus, the aim of this study was to investigate whether more clinically acceptable scan durations are possible. Firstly, the conventional block protocol was compared with a sinusoidal protocol of the same duration of 7 minutes. Estimates of the magnitude of the CVR signal (CVR magnitude) and the relative timing of the CVR response (CVR phase) were found to be in good agreement between the stimulus protocols. Secondly, data from the sinusoidal protocol was reanalysed using decreasing amounts of data in the range 1 to 6 minutes. The CVR magnitude was found to tolerate this reduction in scan duration better than CVR phase. However, these analyses indicate that scan durations in the range of 3 to 5 minutes produce robust data.
Things softly attained are long retained: Dissecting the Impacts of Selection Regimes on Polymorphism Maintenance in Experimental Spatially Heterogeneous Environments
Authors: Gallet Romain , Froissart Rémy , Ravigné Virginie 
Published: January 2017

AbstractThis preprint has been reviewed and recommended by Peer Community In Evolutionary Biology (http://dx.doi.org/10.24072/pci.evolbiol.100020). Predicting and managing contemporary adaption requires a proper understanding of the determinants of genetic variation. Spatial heterogeneity of the environment may stably maintain polymorphism when habitat contribution to the next generation can be considered independent of the degree of adaptation of local populations within habitats (i.e., under soft selection). In contrast, when habitats contribute proportionally to the mean fitness of the populations they host (hard selection), polymorphism is not expected to be maintained by selection. Although mathematically established decades ago, this prediction had never been properly explored. Here we provide an experimental test in which polymorphic populations ofEscherichiacoli growing in heterogeneous habitats were exposed to hard and soft selection regimes. As predicted by theory, polymorphism was longer preserved under soft selection. Complementary tests established that soft selection slowed down fixation processes and could even protect polymorphism on the long term by providing a systematic advantage to rare genotypes.
The Big 4 in Bangladesh: caught between the global and the local
Authors: Belal Ataur , Spence Crawford , Carter Chris , Zhu Jingqi 
Published: January 2017

Purpose
The purpose of this paper is to explore the work practices of Big 4 firms in Bangladesh with the aim of exploring the extent to which global professional service firms (GPSFs) can be thought of as being genuinely “global”.

Design/methodology/approach
Interviews were undertaken with the vast majority of Big 4 partners in Bangladesh. These interviews explored a number of themes related to the professional service work context in Bangladesh and the relationship between local and global firms.

Findings
The central finding of this paper is that although the Big 4 have a long-established presence in Bangladesh, local societal factors heavily influence the realities of work for accountants there. In most cases the Big 4 firms establish correspondent firms (instead of full member firms) in Bangladesh and tend to offer restricted service lines. Additionally, the paper identifies professional, commercial and cultural barriers to greater Big 4 involvement in the local market. Conceptually, the chief contribution of this paper is to explore how the effects of globalizing capitalism and standardised “best practices” in global professional service work are mediated through the societal effects of Bangladeshi society, resulting in the Big 4 having only a tentative presence in the Bangladeshi market.

Research limitations/implications
The findings cast doubt on the extent to which self-styled GPSFs are truly “global” in nature. Future work examining the Big 4, or accounting more generally, in the context of globalization, would do well to pay greater attention to the experience of professionals in emerging markets.

Originality/value
Whilst there has been much work looking at accounting and accountants in the context of globalization, this work has tended to privilege “core” western empirical settings. Very little is known about professional service firms in “peripheral” emerging markets. Furthermore, this study extends the application of the system, society and dominance framework by mapping the interactions and dynamics of these three sources of influence in the setting of PSFs.
Maintenance strategy for public-rented residential building: a case study in Jakarta, Indonesia
Authors: Arumsari Putri , Rarasati Ayomi Dita 
Published: January 2017

Purpose
Several public-rented residential buildings in the Jakarta province are in slum conditions. The purpose of this paper is to propose an alternative maintenance strategy to be adopted by public-rented residential buildings to avoid the creation of slum conditions.

Design/methodology/approach
Qualitative and quantitative methods were adopted. The research first identified factors in maintenance management that affect the physical condition of a building through literature review and preliminary interview with the building occupants and building staffs. The factors are then used to develop a questionnaire that is distributed to 856 respondents in four buildings in East Jakarta. Only 552 completed questionnaires were used to identify the dominant factors through descriptive analysis by calculating the percentage of each answer.

Findings
The research found that the dominant factors in maintenance management, which influence the creation of slums condition in public-rented residential building are the level of damage and quality deterioration of the building material and the level of building maintenance budget availability.

Research limitations/implications
The maintenance situation and regulation regarding public-rented residential buildings in other provinces in Indonesia may not be the same with Jakarta Province due to the local autonomy and local problems. Therefore, the result from this research might not be applicable in other provinces in Indonesia.

Originality/value
This research identifies the factors in maintenance management, which affect the creation of slum conditions in public-rented residential buildings so that necessary maintenance measures can be carried out by the agency in charge.
A finite element analysis of an elastic contact between a layered cylindrical hollow roller and flat contact
Authors: Solanki Mitul Thakorbhai , Vakharia Dipak 
Published: January 2017

Purpose
The purpose of this paper is to present a finite element analysis (FEA) which shows the comparison between a layered cylindrical hollow roller bearing and hollow roller bearing.

Design/methodology/approach
In this work, FEA is carried out to solve the elastic contact between a layered cylindrical hollow roller and flat contact for different hollowness percentages ranging from 10 to 80 per cent. Graphical solution is developed to determine the optimum hollowness of a cylindrical roller bearing for which induced bending stress should be within endurance limit of the material.

Findings
Different parameters such as von Mises stress, contact pressure, contact width and deformation are shown here.

Originality/value
The value of this research work is the calculation of contact width and other parameters using FEA for layered cylindrical hollow roller bearing.
Status-quo vs new strategy in intangibles
Authors: Shakina Elena , Barajas Angel , Parshakov Petr , Chadov Aleksei 
Published: January 2017

PurposeThis study explores company strategies for intangibles. The authors investigate whether it is reasonable for companies to intensify intangibles when the current strategy is not intangible-intensive. The purpose of this paper is to elaborate a theoretical model to describe the strategic decision making in companies.Design/methodology/approachThe authors use the Bellman-equation framework to find the conditions under which a change in strategy for intangibles is reasonable.FindingsThe results determine the parameters of returns on intangibles in different strategies, the optimal intangible stock and the influence of external economic shocks. The findings of the study demonstrate that many requirements have to be met to make intangible-intensive strategy beneficial for a company. Moreover negative shocks of crises force a company to postpone a new strategy on intangibles.Practical implicationsThis research provides an insight into strategic behavior of companies under uncertainty. The theoretical findings demonstrate under which conditions companies should decide to switch to a strategy more intangible-intensive. This model can be used to empirically test parameters of different investment strategies of companies using structural estimation techniques.Originality/valueThis work contributes to the theory of managerial economics giving closed form solutions for the dynamic optimization of company behavior. The findings also show how this behavior might change when economic crises are faced or expected.
Philosophical connections between the classical and the modern notion of corruption
Authors: Dion Michel 
Published: January 2017

Purpose
The purpose of this paper is to circumscribe the various philosophical connections between the classical and the modern notion of corruption from Enlightenment to post-modernity.

Design/methodology/approach
The paper analyzed to what extent the classical notion of corruption (Plato, Aristotle and Cicero) still influenced the way philosophers perceived the phenomenon of corruption during the Enlightenment (1625-1832), the transition period (1833-1900) and the post-modernity (1901 onward). Taking those historical periods as reference points, the author will see how literature about historical, social and political conditioning factors of corruption could convey the presence/absence of the classical or the modern notion of corruption.

Findings
The paper finds that the classical notion of corruption implies the degeneration of human relationships (Plato and Hegel), the degeneration of the body-and-mind unity (Aristotle, Pascal and Thomas Mann) or the degeneration of collective morality (Cicero, Locke, Rousseau, Hume and Kant). The modern notion of corruption as bribery was mainly introduced by Adam Smith. Nietzsche (and Musil) looked at corruption as degeneration of the will-to-power. The classical notion of corruption put the emphasis on the effects rather than on the cause itself (effects-based thinking). The modern notion of corruption as bribery insists on the cause rather than on the effects (cause-based thinking).

Research limitations/implications
In this paper, the author has taken into account the main representatives of the three historical periods. Future research could also analyze the works of other philosophers and novelists to see to what extent their philosophical and literary works are unveiling the classical or the modern notion of corruption.

Originality/value
The paper presents a philosophical and historical perspective about corruption. It sheds light on the way philosophers (and sometimes novelists) deal with the issue of corruption, whether it is from an effects-based or from a cause-based perspective.
A survey on clustering routing protocols in wireless sensor networks
Authors: Gherbi Chirihane , Aliouat Zibouda , Benmohammed Mohamed 
Published: January 2017

Purpose
In particular, this paper aims to systematically analyze a few prominent wireless sensor network (WSN) clustering routing protocols and compare these different approaches according to the taxonomy and several significant metrics.

Design/methodology/approach
In this paper, the authors have summarized recent research results on data routing in sensor networks and classified the approaches into four main categories, namely, data-centric, hierarchical, location-based and quality of service (QoS)-aware, and the authors have discussed the effect of node placement strategies on the operation and performance of WSNs.

Originality/value
Performance-controlled planned networks, where placement and routing must be intertwined and everything from delays to throughput to energy requirements is well-defined and relevant, is an interesting subject of current and future research. Real-time, deadline guarantees and their relationship with routing, mac-layer, duty-cycles and other protocol stack issues are interesting issues that would benefit from further research.
The shape of success in a turbulent world: wave exposure filtering of coral reef herbivory
Authors: Bejarano Sonia , Jouffray Jean‐Baptiste , Chollett Iliana , Allen Robert , Roff George , Marshell Alyssa , Steneck Robert , Ferse Sebastian C. A. , Mumby Peter J. 
Published: January 2017

Summary

While environmental filters are well‐known factors influencing community assembly, the extent to which these modify species functions, and entire ecosystem processes, is poorly understood.

Focusing on a high‐diversity system, we ask whether environmental filtering has ecosystem‐wide effects beyond community assembly. We characterise a coral reef herbivorous fish community for swimming performance based on ten functional traits derived from fish morphology. We then investigate whether wave exposure modifies the functional make‐up of herbivory, and the absolute and relative feeding frequency of distinct feeding functional groups.

Herbivorous fish species conformed to either laterally compressed or fusiform body plans, which differ in their morphological design to minimise drag. High wave exposure selectively limited the feeding function of the deepest body shapes with highest caudal thrust efficiency, and favoured fusiform bodies irrespective of pectoral fin shape.

Traditionally recognised herbivore feeding functional groups (i.e. grazers–detritivores and scrapers–small excavators) differed in swimming performance, and in their capacity to feed consistently across levels of wave exposure. We therefore emphasise the distinctness of their ecological niche and functional complementarity.

Species within the same feeding functional group also had contrasting responses to wave exposure. We thereby reveal a further ecological dimension of niche partitioning, and reiterate the risk of assuming functional redundancy among species with a common feeding mode.

Contrasting responses of species within feeding functional roles (i.e. response diversity) allowed the preservation of critical trophic functions throughout the gradient (e.g. macroalgal browsing), and likely explained why overall levels of herbivory were robust to filtering. Whether ecosystem functioning will remain robust under the additive effects of environmental stress and human‐induced disturbances remains to be tested.

A lay summary is available for this article.