bluuebunny/crossref_metadata_2025_split huggingface dataset:
СТАТЕВІ ВІДМІННОСТІ ПОКАЗНИКІВ ПРО-АНТИОКСИДАНТНОЇ СИСТЕМИ В МІОКАРДІ ЩУРІВ ЗА УМОВ ГІПЕРГОМОЦИСТЕЇНЕМІЇ
Authors: Melnik A. V. 
Published: July 2017

Гіпергомоцистеїнемія є незалежним фактором ризику патології серця та судин. Одним із механізмів кардіотоксичної дії високих концентрацій гомоцистеїну є оксидативний стрес. За умов гіпергомоцистеїнемії в міокарді розвивається про-антиоксидантний дисбаланс, який асоціюється з посиленням процесів вільнорадикального окиснення ліпідів та протеїнів. Однак статеві особливості впливу гіпергомоцистеїнемії на показники про-антиоксидантної системи в міокарді залишаються невивченими.Мета дослідження – оцінити вплив гіпергомоцистеїнемії на показники оксидативного стресу в міокарді та маркери цитолізу кардіоміоцитів у самців та самок щурів.Матеріал і методи. Досліди проведені на 40 білих лабораторних щурах обох статей масою 220–280 г. Модель гіпергомоцистеїнемії створювали шляхом введення тіолактону D, L-гомоцистеїну (Sigma, США) внутрішньошлунково в дозі 100 мг/кг маси протягом 28 діб. У міокарді визначали вміст H2S, активність NADPH-оксидази (КФ 1.6.3.1), супероксиддисмутази (КФ 1.15.1.1), вміст малонового діальдегіду (МДА), карбонільних груп білків (КГ). У сироватці крові оцінювали вміст гомоцистеїну, активність аспартатамінотрасферази (АСТ) та креатинфосфокінази (КФК). Статистичну обробку результатів проводили за допомогою програми SPSS Statistica 17.0.Результати. Тривале введення тіолактону гомоцистеїну супроводжується збільшенням вмісту гомоцистеїну в сироватці крові та зменшенням рівня гідроген сульфіду в міокарді у самців відповідно на 111 та 43,3 % (р˂0,05), а у самок – на 82,4 та 25,1 % (р˂0,05), порівняно з відповідним контролем.У самців з гіпергомоцистеїнемією зменшення активності супероксиддисмутази, а також зростання активності НАДФН-оксидази, вмісту МДА та КГ в міокарді становило відповідно 33,2; 52,7; 89,3 та 102 %, тоді як у самок зміни вказаних показників були меншими і становили 23,7; 33,3; 68,3 та 78,6 % відносно контролю.За умов гіпергомоцистеїнемії у самців розвивається більш виражений цитоліз кардіоміоцитів (активність АСТ та КФК у сироватці крові зростає відповідно на 39,2 та 42,5 % відносно контролю), ніж у самок (активність АСТ та КФК в сироватці крові зростає на 24,9 та 31,3 %).Висновки. Встановлено, що введення тіолактону гомоцистеїну протягом 28 діб викликає у самців більш істотне зменшення активності супероксиддисмутази та збільшення активності НАДФН-оксидази, процесів пероксидації ліпідів і протеїнів, ніж у самок. Поряд з цим у самців реєструється більш виразний цитоліз кардіоміоцитів, ніж у особин протилежної статі.
ПОКАЗНИКИ ЕФЕКТИВНОСТІ ДИСПАНСЕРНОГО НАГЛЯДУ ПАЦІЄНТІВ НА СУКУПНИЙ ПЕРЕБІГ ХРОНІЧНОГО ПАНКРЕАТИТУ І АРТЕРІАЛЬНОЇ ГІПЕРТЕНЗІЇ
Authors: Pasiyeshvili L. M. , V'yun T. I. 
Published: July 2017

Резюме. Велика розповсюдженість артеріальної гіпертензії (АГ) та хронічного панкреатиту (ХП) обумовлює доволі часте поєднання даних захворювань, що потребує визначення впливу кожного з них на дану коморбідність.Мета роботи: визначення вмісту показників ФНП-α та ІЛ-2 у хворих на сукупний перебіг ХП та АГ на етапі диспансерного нагляду.Матеріали та методи дослідження. На етапі амбулаторного спостереження обстежено 27 пацієнтів з коморбідністю ХП та АГ (основна група) та 19 осіб з ізольованим ХП (група порівняння).Висновки. У хворих на ХП (стадія ремісії) та АГ тривалий час зберігаються зміни в показниках ФНП-α та ІЛ-2, що може бути наслідком як латентного перебігу ХП, так і активації апоптозу з формуванням ускладнень. Означені дані можна використовувати в якості контролю призначеної терапії.
Оценка влияния различных видов ишемии в хирургическом лечении рака единственной почки на прогрессию хронической болезни почек
Authors: Pasichnyk S. M. 
Published: July 2017

Мета роботи: вперше провести оцінку впливу застосування різних видів ішемії в хірургічному лікуванні раку єдиної нирки на прогресію хронічної хвороби нирок.Матеріали і методи. Проведено ретроспективний аналіз результатів лікування 68 пацієнтів, яким було виконано резекцію з приводу нирково-клітинного раку (НКР) єдиної нирки. Всі хворі проходили стаціонарне лікування у відділенні пластичної та реконструктивної урологій Національного інституту раку, урологічному відділі Львівської обласної клінічної лікарні.Результати досліджень та їх обговорення. До проведення хірургічного лікування раку нирки (РН) на 2 стадії хронічної хвороби нирок (ХХН ) був один пацієнт першої групи, один пацієнт другої групи та 6 хворих третьої групи. Відповідно 3а стадію ХХН було діагностовано у 5 хворих першої групи, 4 хворих другої групи та 19 пацієнтів третьої групи. 3b стадію ХХН діагностовано у 4 хворих першої групи, 3 хворих другої групи та 12 хворих третьої групи. З четвертою стадією ХХН, до проведення хірургічного лікування, було 3 хворих першої групи, один хворий другої групи та 7 хворих третьої групи. 5 стадію ХХН спостерігали лише у 2 хворих третьої групи. Через три місяці після проведеного хірургічного лікування прогресування ХХН спостерігали у 3пацієнтів першої групи, що становило 23, 1 %. У 2хворих другої групи, що, відповідно, складало 22, 2 %. В третій групі дослідження через три місяці після проведеного хірургічного лікування прогресування ХХН спостерігали у 5 хворих, що становило 10, 9 % випадків.
Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease
Authors: Prakash Stuti , Borreguero Luis J.J. , Sylva Marc , Flores Ruiz Lorena , Rezai Fereshte , Gunst Quinn D. , de la Pompa José-Luis , Ruijter Jan M. , van den Hoff Maurice J.B. 
Published: July 2017

Objective—
Fstl1 (Follistatin-like 1) is a secreted protein that is expressed in the atrioventricular valves throughout embryonic development, postnatal maturation, and adulthood. In this study, we investigated the loss of Fstl1 in the endocardium/endothelium and their derived cells.

Approach and Results—
We conditionally ablated Fstl1 from the endocardial lineage using a transgenic Tie2-Cre mouse model. These mice showed a sustained Bmp and Tgfβ signaling after birth. This resulted in ongoing proliferation and endocardial-to-mesenchymal transition and ultimately in deformed nonfunctional mitral valves and a hypertrophic dilated heart. Echocardiographic and electrocardiographic analyses revealed that loss of Fstl1 leads to mitral regurgitation and left ventricular diastolic dysfunction. Cardiac function gradually deteriorated resulting in heart failure with preserved ejection fraction and death of the mice between 2 and 4 weeks after birth.

Conclusions—
We report on a mouse model in which deletion of Fstl1 from the endocardial/endothelial lineage results in deformed mitral valves, which cause regurgitation, heart failure, and early cardiac death. The findings provide a potential molecular target for the clinical research into myxomatous mitral valve disease.
A Transactional Analysis Model for Evaluating Teacher Behaviors
Authors: Flaro Lloyd 
Published: July 2017

Many theorists believe that the teacher's behavioral transactions with the student is the critical factor in teacher effectiveness. Webb (1971) states that, “The way a teacher behaves, not what he knows, may be the most important issue in the transmission of the teaching-learning exchange. The psychological behavior, the quality of how the teacher relates to the child, is perhaps the most important basis for the learning attitude held by the child.” Other researchers have similarly postulated that teacher behaviors affect self-concept development and school achievement. Some educators have begun to emphasize the central importance of the teacher in the student-teacher exchange process. Educators need the kind of conceptual framework best offered by Transactional Analysis to understand the quality and types of pupil-teacher interactions. Therefore, this paper will develop a model for evaluating teacher behaviors and their effect on school learning.
Substantiated Reports of Child Maltreatment from the Canadian Incidence Study of Reported Child Abuse and Neglect 2008: Examining Child and Household Characteristics and Child Functional Impairment
Authors: Aff Tracie O , Taillieu Tamara , Cheung Kristene , Katz Laurence Y , Tonmyr Lil , Sareen Jitender 
Published: July 2017

Objective: Identifying child and household characteristics that are associated with specific child maltreatment types and child functional impairment are important for informing prevention and intervention efforts. Our objectives were to examine the distribution of several child and household characteristics among substantiated child maltreatment types in Canada; to determine if a specific child maltreatment type relative to all other types was associated with increased odds of child functional impairment; and to determine which child and household characteristics were associated with child functional impairment. Method: Data were from the Canadian Incidence Study of Reported Child Abuse and Neglect (collection 2008) from 112 child welfare sites across Canada ( n = 6163 children). Results: Physical abuse, sexual abuse, and emotional maltreatment were highly prevalent among children aged 10 to 15 years. For single types of child maltreatment, the highest prevalence of single-parent homes (50.6%), social assistance (43.0%), running out of money regularly (30.7%), and unsafe housing (30.9%) were reported for substantiated cases of neglect. Being male, older age, living in a single-parent home, household running out of money, moving 2 or more times in the past year, and household overcrowding were associated with increased odds of child functional impairment. Conclusions: More work is warranted to determine if providing particular resources for single-parent families, financial counselling, and facilitating adequate and stable housing for families with child maltreatment histories or at risk for child maltreatment could be effective for improving child functional outcomes.
Training Teachers of the Gifted to Use Simulations
Authors: Marks Diana F. 
Published: July 2017

You are a general in ancient Rome. Your armies just conquered more new territory. You must establish fortifications along the new frontier. Rome's leaders also expect you to extend the current road. Obviously the inhabitants are not happy to see you in their midst. What ideas do you have? You and your committee of five are part of the directorship of the Metropolitan Musuem of Art. The French government has just announced it is lending the museum the Mona Lisa for a year. The entire art community is in turmoil. Rumors of terrorism against the masterpiece abound. Now what do you do? The 1996 Olympic Committee has hired your company to feed all its athletes at the summer games. You must put together a proposal. What should you do first?
Circulating dsDNA, endothelial injury, and complement activation in thrombotic microangiopathy and GVHD
Authors: Gloude Nicholas J. , Khandelwal Pooja , Luebbering Nathan , Lounder Dana T. , Jodele Sonata , Alder Matthew N. , Lane Adam , Wilkey Alyss , Lake Kelly E. , Litts Bridget , Davies Stella M. 
Published: July 2017

Key PointsdsDNA production peaks 14 days after HSCT, likely a result of IL-8–driven neutrophil recovery. dsDNA production may serve as a mechanistic link between endothelial injury, TA-TMA, and GVHD.
RETRACTED ARTICLE: Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment
Authors: Giacoppo Sabrina , Iori Renato , Rollin Patrick , Bramanti Placido , Mazzon Emanuela 
Published: July 2017

Abstract
Background
Several lines of evidence suggest the consume of natural products for cancer prevention or treatment. In particular, isothiocyanates (ITCs) exerting anti-cancer properties, have received great interest as potential chemotherapeutic agents.
This study was designed to assess the anti-proliferative activities of a new preparation of Moringa oleifera-derived 4-(α-L-rhamnopyranosyloxy)benzyl ITC (moringin) complexed with alpha-cyclodextrin (moringin + α-CD; MAC) on SH-SY5Y human neuroblastoma cells. This new formulation arises in the attempt to overcome the poor solubility and stability of moringin alone in aqueous media.

Methods
SH-SY5Y cells were cultured and exposed to increasing concentrations of MAC (1.0, 2.5 and 5.0 μg). Cell proliferation was examined by MTT and cell count assays. The cytotoxic activity of the MAC complex was assessed by lactate dehydrogenase (LDH) assay and trypan blue exclusion test. In addition, western blotting analyses for the main apoptosis-related proteins were performed.

Results
Treatment of SH-SY5Y cells with the MAC complex reduced cell growth in concentration dependent manner. Specifically, MAC exhibited a potent action in inhibiting the PI3K/Akt/mTOR pathway, whose aberrant activation was found in many types of cancer. MAC was also found to induce the nuclear factor-κB (NF-κB) p65 activation by phosphorylation and its translocation into the nucleus. Moreover, treatment with MAC was able to down-regulate MAPK pathway (results focused on JNK and p38 expression). Finally, MAC was found to trigger apoptotic death pathway (based on expression levels of cleaved-caspase 3, Bax/Bcl-2 balance, p53 and p21).

Conclusion
These findings suggest that use of MAC complex may open novel perspectives to improve the poor prognosis of patients with neuroblastoma.
Inter‐segmental motions of the foot: differences between younger and older healthy adult females
Authors: Lee Dong Yeon , Seo Sang Gyo , Kim Eo Jin , Lee Doo Jae , Bae Kee Jeong , Lee Kyoung Min , Choi In Ho 
Published: July 2017

AbstractBackgroundAlthough accumulative evidence exists that support the applicability of multi‐segmental foot models (MFMs) in evaluating foot motion in various pathologic conditions, little is known of the effect of aging on inter‐segmental foot motion. The objective of this study was to evaluate differences in inter‐segmental motion of the foot between older and younger adult healthy females during gait using a MFM with 15‐marker set.MethodsOne hundred symptom‐free females, who had no radiographic evidence of osteoarthritis, were evaluated using MFM with 15‐marker set. They were divided into young (n = 50, 20–35 years old) and old (n = 50, 60–69 years old) groups. Coefficients of multiple correlations were evaluated to assess the similarity of kinematic curve. Inter‐segmental angles (hindfoot, forefoot, and hallux) were calculated at each gait phase. To evaluate the effect of gait speed on intersegmental foot motion, subgroup analysis was performed according to the similar speed of walking.ResultsKinematic curves showed good or excellent similarity in most parameters. Range of motion in the sagittal (p < 0.001) and transverse (p = 0.001) plane of the hallux, and sagittal (p = 0.023) plane of the forefoot was lower in older females. The dorsiflexion (p = 0.001) of the hallux at terminal stance and pre‐swing phases was significantly lower in older females. When we compared young and older females with similar speed, these differences remained.ConclusionsAlthough the overall kinematic pattern was similar between young and older females, reduced range of inter‐segmental motion was observed in the older group. Our results suggest that age‐related changes need to be considered in studies evaluating inter‐segmental motion of the foot.
Genome-wide analysis of facial skeletal regionalization in zebrafish
Authors: Askary Amjad , Xu Pengfei , Barske Lindsey , Bay Maxwell , Bump Paul , Balczerski Bartosz , Bonaguidi Michael A. , Crump J. Gage 
Published: July 2017

ABSTRACT
Patterning of the facial skeleton involves the precise deployment of thousands of genes in distinct regions of the pharyngeal arches. Despite the significance for craniofacial development, how genetic programs drive this regionalization remains incompletely understood. Here we use combinatorial labeling of zebrafish cranial neural crest-derived cells (CNCCs) to define global gene expression along the dorsoventral axis of the developing arches. Intersection of region-specific transcriptomes with expression changes in response to signaling perturbations demonstrates complex roles for Endothelin 1 (Edn1) signaling in the intermediate joint-forming region, yet a surprisingly minor role in ventralmost regions. Analysis of co-variance across multiple sequencing experiments further reveals clusters of co-regulated genes, with in situ hybridization confirming the domain-specific expression of novel genes. We then created loss-of-function alleles for 12 genes and uncovered antagonistic functions of two new Edn1 targets, follistatin a (fsta) and emx2, in regulating cartilaginous joints in the hyoid arch. Our unbiased discovery and functional analysis of genes with regional expression in zebrafish arch CNCCs reveals complex regulation by Edn1 and points to novel candidates for craniofacial disorders.
A novel diagnostic aid for intra-abdominal adhesion detection in cine-MRI: pilot study and initial diagnostic impressions
Authors: Randall David , Joosten Frank , Ten Broek Richard Peter , Gillott Richard , Bardhan Karna Dev , Strik Chema , Prins Wiesje , van Goor Harry , Fenner John Wesley 
Published: July 2017

Objective:
A non-invasive diagnostic technique for abdominal adhesions is not currently available. Capture of abdominal motion due to respiration in cine-MRI has shown promise, but is difficult to interpret. This article explores the value of a complimentary diagnostic aid to facilitate the non-invasive detection of abdominal adhesions using cine-MRI.

Method:
An image processing technique was developed to quantify the amount of sliding that occurs between the organs of the abdomen and the abdominal wall in sagittal cine-MRI slices. The technique produces a “sheargram” which depicts the amount of sliding which has occurred over 1–3 respiratory cycles. A retrospective cohort of 52 patients, scanned for suspected adhesions, made 281 cine-MRI sagittal slices available for processing. The resulting sheargrams were reported by two operators and compared with expert clinical judgment of the cine-MRI scans.

Results:
The sheargram matched clinical judgment in 84% of all sagittal slices and 93–96% of positive adhesions were identified on the sheargram. The sheargram displayed a slight skew towards sensitivity over specificity, with a high positive adhesion detection rate but at the expense of false positives.

Conclusion:
Good correlation between sheargram and absence/presence of inferred adhesions indicates quantification of sliding motion has potential to aid adhesion detection in cine-MRI.

Advances in knowledge:
This is the first attempt to clinically evaluate a novel image processing technique quantifying the sliding motion of the abdominal contents against the abdominal wall. The results of this pilot study reveal its potential as a diagnostic aid for detection of abdominal adhesions.
Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema
Authors: Fujimori Motoshi , Nakamura Satoko , Hasegawa Kiminori , Ikeno Kunihiro , Ichikawa Shota , Sutherland Kenneth , Kamishima Tamotsu 
Published: July 2017

Abstract

Objective:
To quantify wrist cartilage using contrast MRI and compare with the extent of adjacent synovitis and bone marrow edema (BME) in patients with rheumatoid arthritis (RA).

Methods:
18 patients with RA underwent post-contrast fat-suppressed T 1weighted coronal imaging. Cartilage area at the centre of the scaphoid-capitate and radius-scaphoid joints was measured by in-house developed software. We defined cartilage as the pixels with signal intensity between two thresholds (lower: 0.4, 0.5 and 0.6 times the muscle signal, upper: 0.9, 1.0, 1.1, 1.2 and 1.3 times the muscle signal). We investigated the association of cartilage loss with synovitis and BME score derived from RA MRI scoring system.

Results:
Cartilage area was correlated with BME score when thresholds were adequately set with lower threshold at 0.6 times the muscle signal and upper threshold at 1.2 times the muscle signal for both SC (r s=−0.469, p &lt; 0.05) and RS (r s=−0.486, p &lt; 0.05) joints, while it showed no significant correlation with synovitis score at any thresholds.

Conclusion:
Our software can accurately quantify cartilage in the wrist and BME associated with cartilage loss in patients with RA.

Advances in knowledge:
Our software can quantify cartilage using conventional MR images of the wrist. BME is associated with cartilage loss in RA patients.
PET/MRI—knocking on the doors of the rich and famous
Authors: Beyer Thomas , Hacker Marcus , Goh Vicky 
Published: July 2017

Since 2010 the portfolio of positron emission tomography (PET)-based imaging has been expanded by industry with the introduction of combined whole-body PET/MRI systems with the intent of merging PET-based molecular imaging with the strengths of MRI. PET/MRI has created a lot of hype in the scientific community but comparatively little traction in the clinic. The first years of whole-body PET/MRI were used to address inherent technical challenges; however, it is now time to make use of the full potential of this integrated imaging modality. This opinion piece highlights the continuing challenges for the clinical adoption of PET/MRI and cautions against putting too much emphasis on comparisons with clinical PET/CT. In order for PET/MRI to enter clinical practice, cross-specialty co-operation must be pursued with rigour and use-case scenarios must be propagated, following long-awaited expansion of reimbursement strategies and protocol standardization.
ACTIVE AND PASSIVE SAFETY VEHICLES
Authors: Тарасова  , Tarasova E. , Дорохин  , Dorokhin S. 
Published: July 2017

The article describes the basic elements of active and passive safety, as well as their impact on the consequences of road accidents. Shows the interaction of systems of active and passive safe-
ty in the event of a frontal collision, side collision, rear impact, rollover
Thermal polarization mechanism of sap flow during the spring equinox
Authors: Камалова  , Kamalova Nina , Евсикова  , Evsikova Natalya , Матвеев  , Matveev Nikolay , Лисицын  , Lisitsyn V. 
Published: July 2017

This article seeks the answer to the question of how the distribution of the concentration of
dissolved minerals in the sap after the winter period in the xylem is made, if in the fall due to low
winter temperatures tree tends to reduce the amount of water and sap in its pores. In search of an
answer it is invited to consider thermal polarization effects in the xylem of tree trunks during the
spring equinox. The results of monitoring of daily average temperature showed that during the winter
the temperature of the day varies in the amount of one and a half times greater than during the
night, and in February this change is almost the same. Whereas in March the temperature change
occurs in series, they sometimes are different in three times. Maximum temperature change for the
day and night is achieved during the spring equinox, on average, it is ten degrees. Such a temperature
change is accompanied by sharp changes in temperature during the days, which, according to
the estimates, give rise to an electric field in the xylem along the trunk. Under this approach, in the
work estimated expression was theoretically derived for the concentration of salt ions in the xylem
of tree trunks, giving reason to believe that the described mechanism also contributes to the value of
the osmotic pressure. All these considerations lead to the assumption that intensive spring sap flow
(in the absence of currents of transpiration) is stimulated by thermal polarization effects in the xylem
of the trunk, caused by the intense ambient temperature changes during this period.