bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Extended Implementation of Fault Detection in Multi-State Systems Based on Warp Analysis: A Case Study on Natural Gas Transmission Systems in Tropical Regions
Authors: Pinzón Horacio , Audivet Cinthia , Portnoy Ivan , Consuegra Marlon , Alexander Javier , Sanjuán Marco 
Published: January 2018

Natural gas transmission infrastructure is a large-scale complex system often exhibiting a considerable operating states not only due to natural, slow and normal process changes related to aging but also to a dynamic interaction with multiple agents overall having different functional parameters, an irregular demand trend adjusted by the hour, and sometimes affected by external conditions as severe climate periods.
As traditional fault detection relies in alarm management system and operator’s expertise, it is paramount to deploy a strategy being able to update its underlying structure and effectively adapting to such process shifts. This feature would allow operators and engineers to have a better framework to address the online data being gathered in dynamic on transient conditions.
This paper presents an extended analysis on WARP technique to address the abnormal condition management activities of multiple-state processes deployed in critical natural gas transmission infrastructure. Special emphasis is made on the updating activity to incorporate effectively the operating shifts exhibited by a new operating condition implemented on a fault detection strategy. This analysis broadens the authors’ original algorithm scope to include multi-state systems in addition to process drifting behavior.
The strategy is assessed under two different scenarios rendering a major shift in process’ operating conditions related to natural gas transmission systems: A transition between low and high natural gas demand to support hydroelectric generation matrix on severe tropical conditions. Performance evaluation of fault detection algorithm is carried out based on false alarm rate, detection time and misdetection rate estimated around the model update.
Synthesis, Stability and Selection Study of Oil-in-Water Nanoemulsions Containing Nigella Sativa L. Essential Oil
Authors: Usta Aybala , Rahman Muhammad , Asmatulu Ramazan 
Published: January 2018

Targeted drug delivery has a great importance in cancer treatment and is in interest of many scientists worldwide. Targeted drug delivery renders local treatment of cancerous cells possible without affecting healthy cells. Hydrogels are promising materials to be used in targeted drug delivery systems due to their biocompatible nature and injectable behaviors where they can be used to load drugs. However, considering that not all the drugs are water soluble, entrapment of some drugs into hydrogels is not practical in terms of poor drug solubility and burst drug release because of this. At this point, an oil phase can be considered as a drug carrying agent, and entrapment of this oil phase into hydrogel would make it possible for in-situ injection of dissolved drug in oil phase.
Oil in water (O/W)-type nanoemulsions were prepared using black seed oil, which is known to cause apoptosis via p-53 dependent mechanism, water and Triton X-100, Span-80 surfactant combinations. Three different oil percentage and three different surfactant percentage were tested, and stability behaviors of nanoemulsions were investigated and compared. Dynamic light scattering analysis and zeta potential measurements were conducted for determination of particles sizes and surface charges of the nanoemulsions. The most stable nanoemulsion along with having smallest diameter and lowest polydispersity index (PDI) was used for further studies. Results indicated that using both hydrophilic and hydrophobic surfactants together increased the stability of nanoemulsions compared to those using either of them.
Numerical Project for the Undergraduate Heat Transfer Course
Authors: Fadda Dani 
Published: January 2018

A numerical simulation project, described in this paper, was assigned in an undergraduate heat transfer course in the mechanical engineering curriculum. This project complemented the heat transfer lecture course and its corresponding heat transfer lab. It was used to help students visualize and better understand the difference between conduction heat transfer which occurs within a three-dimensional solid body and the convection and/or radiation which occur at the surface of the solid body. It also allowed the students to generate and compare results of one dimensional heat transfer calculations to three dimensional simulation results.
The project contained well defined deliverables and an open-ended deliverable which allowed students to be creative. It gave the students reason to discuss the course outside the classroom. It allowed students to use SolidWorks heat transfer simulation and manage a MATLAB script without taking classroom time. It was appreciated and enjoyed by the students.
Vibration Analysis of High-Speed End Milling Operations Applied to Injection Mold Materials
Authors: Logins Andris , Torims Toms , Rosado Castellano Pedro , Gutiérrez Santiago , Torres Rafael 
Published: January 2018

High-speed milling has often been applied in injection mold manufacturing processes, where surface roughness is a significant criterion in product quality demands. It is equally applicable to automotive or industrial engineering and to toy manufacturing, where plastic parts with a high-quality surface finish have been processed using the injection molding technique. High-speed milling involves a number of process parameters that may affect the 3D surface topography formation. Literature analysis reveals that dynamical behavior is a significant factor in the end milling process on surface roughness parameters. To improve the accuracy of predicted surface topography models, it is important to include the dynamical behavior of milling factor.
This paper describes the surface prediction model of combined end-milling geometrical and dynamical interaction models. The natural frequency of machine assembly and forced vibrations during the cutting process were measured during the flat-end milling process. Unevenly distributed cutting marks were revealed by surface 3D topography images and microscopy images of the machined samples.
A mathematical model to predict surface topography was developed, including dynamical behavior and cutting geometries. Machine accuracy also has to be addressed. 3D surface topography parameters from the experimental sample provided the results for the mathematical prediction model. This model offers a software tool for manufacturers to improve the quality of machined part surfaces, taking into account the behavioral properties of their machining equipment. Relevant conclusions about the manufacturing equipment accuracy have been drawn. Vibrations in the milling system affect the cutting process and contribute to the surface topography prediction model. Local cutting tool vibrations do not have any influence on surface parameter mean values.
In Vitro
Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes
Authors: Cern Ahuva , Connolly Kristie L. , Jerse Ann E. , Barenholz Yechezkel 
Published: January 2018

ABSTRACT

Neisseria gonorrhoeae
is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94
N. gonorrhoeae
strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant
N. gonorrhoeae
.
Complete Genome Sequence of a Bacteriophage, pVco-5, That Infects
Vibrio coralliilyticus
, Which Causes Bacillary Necrosis in Pacific Oyster (
Crassostrea gigas
) Larvae
Authors: Kim Hyoun Joong , Jun Jin Woo , Giri Sib Sankar , Chi Cheng , Yun Saekil , Kim Sang Guen , Kim Sang Wha , Kang Jeong Woo , Han Se Jin , Park Se Chang 
Published: January 2018

ABSTRACT

We report here the complete genome sequence of the
Vibrio coralliilyticus
-specific phage pVco-5, a double-stranded DNA virus isolated from an oyster hatchery tank.
Vibrio coralliilyticus
causes bacillary necrosis in marine bivalve larvae; hence, phage pVco-5 could be used to prevent
V. coralliilyticus
infections in these larvae.
Eight Genome Sequences of Cluster BE1 Phages That Infect
Streptomyces
Species
Authors: Hughes Lee E. , Shaffer Christopher D. , Ware Vassie C. , Aguayo Issac , Aziz Rahat M. , Bhuiyan Swapan , Bindert Isaac S. , Calovich-Benne Canyon K. , Chapman Jordyn , Donegan-Quick Richard , Farooq Amal , Garcia Cynthia , Graham Lee H. , Green Baylee Y. , Kenna Margaret A. , Kneeream Emily R. , Laing Christian E. , Mageeney Catherine M. , Meridew Sandra N. , Mikolon Abigail R. , Morgan Ryann E. , Nayek Subhayu , Olugbade Idowu D. , Pike Kim C. , Schlegel Lauren E. , Shishido Taylor C. , Suresh Tara , Suri Nikita , Weston Hafer Kathleen , Garlena Rebecca A. , Russell Daniel A. , Cresawn Steven G. , Pope Welkin H. , Jacobs-Sera Deborah , Hatfull Graham F. 
Published: January 2018

ABSTRACT

Cluster BE1
Streptomyces
bacteriophages belong to the
Siphoviridae
, with genome sizes over 130 kbp, and they contain direct terminal repeats of approximately 11 kbp. Eight newly isolated closely related cluster BE1 phages contain 43 to 48 tRNAs, one transfer-messenger RNA (tmRNA), and 216 to 236 predicted open reading frames (ORFs), but few of their genes are shared with other phages, including those infecting
Streptomyces
species.
Complete Genome Sequence of the
Escherichia coli
Phage Ayreon
Authors: Vlot Marnix , Nobrega Franklin L. , Wong Che F. A. , Liu Yue , Brouns Stan J. J. 
Published: January 2018

ABSTRACT

We report the whole-genome sequence of a new
Escherichia coli
temperate phage, Ayreon, comprising a linear double-stranded DNA (dsDNA) genome of 44,708 bp.
Complete Genome Sequence of
Chryseobacterium camelliae
Dolsongi-HT1, a Green Tea Isolate with Keratinolytic Activity
Authors: Kim Eun-Mi , Hwang Kyeong Hwan , Park Jun-Seong 
Published: January 2018

ABSTRACT

The complete genome sequence of
Chryseobacterium camelliae
Dolsongi-HT1 is reported here.
C. camelliae
Dolsongi-HT1, having keratinolytic activity, was isolated from green tea leaves in the Dolsongi tea garden in Jeju, South Korea. The strain Dolsongi-HT1 has 28 candidate protease genes, which may be utilized in further studies and industrial applications of keratinase.
Coassociation between Group B Streptococcus and Candida albicans Promotes Interactions with Vaginal Epithelium
Authors: Pidwill Grace R. , Rego Sara , Jenkinson Howard F. , Lamont Richard J. , Nobbs Angela H. 
Published: January 2018

ABSTRACTGroup BStreptococcus(GBS) is a leading cause of neonatal sepsis, pneumonia, and meningitis worldwide. In the majority of cases, GBS is transmitted vertically from mother to neonate, making maternal vaginal colonization a key risk factor for neonatal disease. The fungusCandida albicansis an opportunistic pathogen of the female genitourinary tract and the causative agent of vaginal thrush. Carriage ofC. albicanshas been shown to be an independent risk factor for vaginal colonization by GBS. However, the nature of interactions between these two microbes is poorly understood. This study provides evidence of a reciprocal, synergistic interplay between GBS andC. albicansthat may serve to promote their cocolonization of the vaginal mucosa. GBS strains NEM316 (serotype III) and 515 (serotype Ia) are shown to physically interact withC. albicans, with the bacteria exhibiting tropism for candidal hyphal filaments. This interaction enhances association levels of both microbes with the vaginal epithelial cell line VK2/E6E7. The ability of GBS to coassociate withC. albicansis dependent upon expression of the hypha-specific adhesin Als3. In turn, expression of GBS antigen I/II family adhesins (Bsp polypeptides) facilitates this coassociation and confers upon surrogateLactococcus lactisthe capacity to exhibit enhanced interactions withC. albicanson vaginal epithelium. As genitourinary tract colonization is an essential first step in the pathogenesis of GBS andC. albicans, the coassociation mechanism reported here may have important implications for the risk of disease involving both of these pathogens.
Overview of the ASSETS 2017 conference
Authors: Hurst Amy , Findlater Leah , Morris Meredith Ringel 
Published: January 2018

This year was the 19th edition of the ACM SIGACCESS International Conference on Computers and Accessibility (ASSETS 2017), which took place in October in Baltimore, Maryland, USA. The ASSETS conference is the premier computing research conference exploring the design, evaluation, and use of computing and information technologies to benefit people with disabilities and older adults. We set a new attendance this year with 200 participants from across the globe. In addition to a rich technical program, an increase in industrial sponsorship allowed the conference to support several receptions, including an event at the National Federation of the Blind on Halloween evening.
SIGACCESS made several awards during this year's conference. The SIGACCESS ASSETS Paper Impact Award was awarded to Keith Edwards, Elizabeth Mynatt and Kathryn Stockton for their 1994 paper "Providing access to graphical user interfaces---not graphical screens". This paper is one of the first to raise and tackle the challenge of providing screen reader capabilities in graphical user interfaces. It proposes that translation of the GUI should be done at a semantic, rather than syntactic level. The 2017 Best Paper Award went to "Evaluating the Usability of Automatically Generated Captions for People who are Deaf or Hard of Hearing" by Sushant Kafle and Matt Huenerfauth. The 2017 Best Student Paper Award went to "Technology-Mediated Sight: A Case Study of Early Adopters of a Low Vision Assistive Technology" by Annuska Zolyomi, Anushree Shukla, and Jaime Snyder. We thank Clayton Lewis from University of Colorado Boulder for Chairing the SIGACCESS Awards Committee and Anne Marie Piper from Northwestern University for chairing the 2017 ASSETS Best Papers Committee.
How do ideas flow around SIGMM conferences?
Authors: Xie Lexing 
Published: January 2018

The ACM Multimedia conference just celebrated its quarter century in October 2017. This is a great opportunity to reflect on the intellectual influence of the conference, and the SIGMM community in general.
The progress on big scholarly data allows us to make this task analytical. I download a data dump from Microsoft Academic Graph (MAG) in February 2016. I find all papers from ACM Multimedia (MM), the SIGMM flagship conference - there are 4,346 publication entries from 1993 to 2015. I then search the entire MAG for: (1) any paper that appears in the reference list of these MM papers - 35,829 entries across 1,560 publication venues (including both journals and conferences), with an average of 8.24 per paper; (2) any paper that cites any of these MM papers - 46826 citations from 1694 publication venues, with an average of 10.77 citations per paper.
This data allows us to profile the incoming (references) and outgoing (citations) influence in the community in detail.
A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons
Authors: Jaffe David B. , Brenner Robert 
Published: January 2018

The gain of a neuron, the number and frequency of action potentials triggered in response to a given amount of depolarizing injection, is an important behavior underlying a neuron’s function. Variations in action potential waveform can influence neuronal discharges by the differential activation of voltage- and ion-gated channels long after the end of a spike. One component of the action potential waveform, the afterhyperpolarization (AHP), is generally considered an inhibitory mechanism for limiting firing rates. In dentate gyrus granule cells (DGCs) expressing fast-gated BK channels, large fast AHPs (fAHP) are paradoxically associated with increased gain. In this article, we describe a mechanism for this behavior using a computational model. Hyperpolarization provided by the fAHP enhances activation of a dendritic inward current (a T-type Ca2+channel is suggested) that, in turn, boosts rebound depolarization at the soma. The model suggests that the fAHP may both reduce Ca2+channel inactivation and, counterintuitively, enhance its activation. The magnitude of the rebound depolarization, in turn, determines the activation of a subsequent, slower inward current (a persistent Na+current is suggested) limiting the interspike interval. Simulations also show that the effect of AHP on gain is also effective for physiologically relevant stimulation; varying AHP amplitude affects interspike interval across a range of “noisy” stimulus frequency and amplitudes. The mechanism proposed suggests that small fAHPs in DGCs may contribute to their limited excitability.NEW & NOTEWORTHY The afterhyperpolarization (AHP) is canonically viewed as a major factor underlying the refractory period, serving to limit neuronal firing rate. We recently reported that enhancing the amplitude of the fast AHP (fAHP) in a relatively slowly firing neuron (vs. fast spiking neurons) expressing fast-gated BK channels augments neuronal excitability. In this computational study, we present a novel, quantitative hypothesis for how varying the amplitude of the fAHP can, paradoxically, influence a subsequent spike tens of milliseconds later.
Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells
Authors: Liu Chang , Nie Danian , Li Juan , Du Xin , Lu Yuhong , Li Yangqiu , Zhou Jingfeng , Jin Yanli , Pan Jingxuan 
Published: January 2018

Abstract
Imatinib revolutionized the treatment of chronic myeloid leukemia (CML), but drug resistance and disease recurrence remain a challenge. In this study, we suggest a novel strategy based on blocking protein neddylation to address BCR-ABL point mutations and leukemia stem cells (LSC) that lie at the root of imatinib-resistant recurrences. On the basis of the finding that the NEDD8-activating enzyme subunit NAE1 is overexpressed in CML cells, we hypothesized that the function of certain neddylation-dependent protein substrates might be targeted to therapeutic ends in imatinib-resistant CML cells and LSCs. In support of this hypothesis, we demonstrated that the NAE1 inhibitor MLN4924 induced G2–M-phase arrest and apoptosis in bulk CML cells with wild-type p53, regardless of their T315I mutation status in BCR-ABL. Moreover, MLN4924 inhibited the survival and self-renewal of primary human CML CD34+ cells and LSCs in CML-bearing mice via accumulation of p27kip1 in the nucleus. Notably, p27kip1 silencing attenuated the suppressive effect of MLN4924 on the maintenance of LSCs in CML-bearing mice. Taken together, our findings offer a preclinical proof of concept for targeting protein neddylation as a novel therapeutic strategy to override mutational and LSC-derived imatinib resistance in CML.
Significance: These findings highlight a mediator of protein neddylation, a type of protein turnover mechanism, as a viable therapeutic target against imatinib-resistant forms of chronic myelogenous leukemia. Cancer Res; 78(6); 1522–36. ©2018 AACR.
Black Hole Sign Predicts Poor Outcome in Patients with Intracerebral Hemorrhage
Authors: Li Qi , Yang Wen-Song , Chen Sheng-Li , Lv Fu-Rong , Lv Fa-Jin , Hu Xi , Zhu Dan , Cao Du , Wang Xing-Chen , Li Rui , Yuan Liang , Qin Xin-Yue , Xie Peng 
Published: January 2018

<b><i>Background:</i></b> In spontaneous intracerebral hemorrhage (ICH), black hole sign has been proposed as a promising imaging marker that predicts hematoma expansion in patients with ICH. The aim of our study was to investigate whether admission CT black hole sign predicts hematoma growth in patients with ICH. <b><i>Methods:</i></b> From July 2011 till February 2016, patients with spontaneous ICH who underwent baseline CT scan within 6 h of symptoms onset and follow-up CT scan were recruited into the study. The presence of black hole sign on admission non-enhanced CT was independently assessed by 2 readers. The functional outcome was assessed using the modified Rankin Scale (mRS) at 90 days. Univariate and multivariable logistic regression analyses were performed to assess the association between the presence of the black hole sign and functional outcome. <b><i>Results:</i></b> A total of 225 patients (67.6% male, mean age 60.3 years) were included in our study. Black hole sign was identified in 32 of 225 (14.2%) patients on admission CT scan. The multivariate logistic regression analysis demonstrated that age, intraventricular hemorrhage, baseline ICH volume, admission Glasgow Coma Scale score, and presence of black hole sign on baseline CT independently predict poor functional outcome at 90 days. There are significantly more patients with a poor functional outcome (defined as mRS ≥4) among patients with black hole sign than those without (84.4 vs. 32.1%, <i>p &#x3c;</i> 0.001; OR 8.19, <i>p</i> = 0.001). <b><i>Conclusions:</i></b> The CT black hole sign independently predicts poor outcome in patients with ICH. Early identification of black hole sign is useful in prognostic stratification and may serve as a potential therapeutic target for anti-expansion clinical trials.
Mortality After Magnetic Resonance Imaging of the Brain in Patients With Cardiovascular Implantable Devices
Authors: Padmanabhan Deepak , Jondal Mary L. , Hodge David O. , Mehta Ramila A. , Acker Nancy G. , Dalzell Connie M. , Kapa Suraj , Asirvatham Samuel J. , Cha Yong-Mei , Felmlee Joel P. , Watson Robert E. , Friedman Paul A. 
Published: January 2018

Background:
Use of magnetic resonance imaging (MRI) brain is restricted in patients with cardiovascular implantable electronic devices (CIEDs). We proposed to determine whether mortality difference exists for patients with non–MRI-conditional CIEDs undergoing brain MRI compared with controls.

Methods and Results:

Retrospective analysis of prospectively collected data was performed to compare all-cause mortality in patients with CIEDs undergoing brain MRI (CIED-MRI) with 3 control groups matched for age, sex, imaging year, and type of CIED: (1) no CIED, brain MRI (no–CIED-MRI); (2) CIED, brain computerized tomography (CT) scan (CIED-CT); and (3) no CIED, brain CT (no–CIED-CT). The primary outcome was a significant difference (
P
<0.05) between estimated mortality rates. Secondary outcomes were changes in device function before and after brain MRI. The estimated all-cause mortality at 5 years for the CIED-MRI group [mean age (±SD), 68.2 years (15.3 years); 61.2% men] was not significantly different from patients who underwent CT with or without a device (CIED-CT group: hazard ratio, 0.814; 95% confidence interval, 0.593–1.117;
P
=0.2; no–CIED-CT group: hazard ratio, 1.149; 95% confidence interval, 0.818–1.613;
P
=0.4). There was a significant increase in mortality between CIED-MRI and no–CIED-MRI groups (hazard ratio, 1.463; 95% confidence interval, 1.019–2.099;
P
=0.04).

Conclusions:
Brain MRI in patients with CIEDs does not carry an increased mortality risk compared with brain CT and can be performed with adherence to appropriate procedural protocols.