bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-IbΔC-X Mice
Authors: Seidl Matthias D. , Stein Juliane , Hamer Sabine , Pluteanu Florentina , Scholz Beatrix , Wardelmann Eva , Huge Andreas , Witten Anika , Stoll Monika , Hammer Elke , Völker Uwe , Müller Frank U. 
Published: August 2017

Background—
Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial fibrillation (AF) susceptibility in patients. Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-IbΔC-X in transgenic mice (TG) leads to spontaneous-onset AF preceded by atrial dilatation and conduction abnormalities. Here, we characterized the altered gene program linked to atrial remodeling and development of AF in CREM-TG mice.

Methods and Results—

Atria of young (TGy, before AF onset) and old (TGo, after AF onset) TG mice were investigated by mRNA microarray profiling in comparison with age-matched wild-type controls (WTy/WTo). Proteomic alterations were profiled in young mice (8 TGy versus 8 WTy). Annotation of differentially expressed genes revealed distinct differences in biological functions and pathways before and after onset of AF. Alterations in metabolic pathways, some linked to altered peroxisome proliferator–activated receptor signaling, muscle contraction, and ion transport were already present in TGy. Electron microscopy revealed significant loss of sarcomeres and mitochondria and increased collagen and glycogen deposition in TG mice. Alterations in electrophysiological pathways became prominent in TGo, concomitant with altered gene expression of K
+
-channel subunits and ion channel modulators, relevant in human AF.

Conclusions—
The most prominent alterations of the gene program linked to CREM-induced atrial remodeling were identified in the expression of genes related to structure, metabolism, contractility, and electric activity regulation, suggesting that CREM transgenic mice are a valuable experimental model for human AF pathophysiology.
Health-Related Quality of Life Outcomes in PARADIGM-HF
Authors: Lewis Eldrin F. , Claggett Brian L. , McMurray John J. V. , Packer Milton , Lefkowitz Martin P. , Rouleau Jean L. , Liu Jiankang , Shi Victor C. , Zile Michael R. , Desai Akshay S. , Solomon Scott D. , Swedberg Karl 
Published: August 2017

Background
Patients with heart failure and reduced ejection fraction have impaired health-related quality of life (HRQL) with variable responses to therapies that target mortality and heart failure hospitalizations. In PARADIGM-HF trial (Prospective Comparison of ARNI [Angiotensin Receptor–Neprilysin Inhibitor] With ACEI [Angiotensin-Converting–Enzyme Inhibitor] to Determine Impact on Global Mortality and Morbidity in Heart Failure), sacubitril/valsartan reduced morbidity and mortality compared with enalapril. Another major treatment goal is to improve HRQL. Given improvements in mortality with sacubitril/valsartan, this analysis provides comprehensive assessment of impact of therapy on HRQL in survivors only.

Methods and Results

Patients (after run-in phase) completed disease-specific HRQL using Kansas City Cardiomyopathy Questionnaire (KCCQ) at randomization, 4 month, 8 month, and annual visits. Changes in KCCQ scores were calculated using repeated measures analysis of covariance model that adjusted for treatment and baseline values (principal efficacy prespecified at 8 months). Among the 8399 patients enrolled in PARADIGM-HF, 7623 (91%) completed KCCQ scores at randomization with complete data at 8 months for 6881 patients (90% of baseline). At 8 months, sacubitril/valsartan group noted improvements in both KCCQ clinical summary score (+0.64 versus −0.29;
P
=0.008) and KCCQ overall summary score (+1.13 versus −0.14;
P
<0.001) in comparison to enalapril group and significantly less proportion of patients with deterioration (≥5 points decrease) of both KCCQ scores (27% versus 31%;
P
=0.01). Adjusted change scores demonstrated consistent improvements in sacubitril/valsartan compared with enalapril through 36 months.

Conclusions
Change scores in KCCQ clinical summary scores and KCCQ overall summary scores were better in patients treated with sacubitril/valsartan compared with those treated with enalapril, with consistency in most domains, and persist during follow-up beyond 8 months. These findings demonstrate that sacubitril/valsartan leads to better HRQL in surviving patients with heart failure.

Clinical Trial Registration

URL:
http://www.c
linicalt
rials.gov
. Unique identifier: NCT01035255.
Consumer-Based Physical Activity Monitor as a Practical Way to Measure Walking Intensity During Inpatient Stroke Rehabilitation
Authors: Klassen Tara D. , Semrau Jennifer A. , Dukelow Sean P. , Bayley Mark T. , Hill Michael D. , Eng Janice J. 
Published: August 2017

Background and Purpose—
Identifying practical ways to accurately measure exercise intensity and dose in clinical environments is essential to advancing stroke rehabilitation. This is especially relevant in monitoring walking activity during inpatient rehabilitation where recovery is greatest. This study evaluated the accuracy of a readily available consumer-based physical activity monitor during daily inpatient stroke rehabilitation physical therapy sessions.

Methods—
Twenty-one individuals admitted to inpatient rehabilitation were monitored for a total of 471 one-hour physical therapy sessions which consisted of walking and nonwalking therapeutic activities. Participants wore a consumer-based physical activity monitor (Fitbit One) and the gold standard for assessing step count (StepWatch Activity Monitor) during physical therapy sessions. Linear mixed modeling was used to assess the relationship of the step count of the Fitbit to the StepWatch Activity Monitor. Device accuracy is reported as the percent error of the Fitbit compared with the StepWatch Activity Monitor.

Results—
A strong relationship (slope=0.99; 95% confidence interval, 0.97–1.01) was found between the number of steps captured by the Fitbit One and the StepWatch Activity Monitor. The Fitbit One had a mean error of 10.9% (5.3) for participants with walking velocities <0.4 m/s, 6.8% (3.0) for walking velocities between 0.4 and 0.8 m/s, and 4.4% (2.8) for walking velocities >0.8 m/s.

Conclusions—
This study provides preliminary evidence that the Fitbit One, when positioned on the nonparetic ankle, can accurately measure walking steps early after stroke during inpatient rehabilitation physical therapy sessions.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01915368.
Quantifying the Accuracy and Uncertainty of Diurnal Thermodynamic Profiles and Convection Indices Derived from the Atmospheric Emitted Radiance Interferometer
Authors: Blumberg W. G. , Wagner T. J. , Turner D. D. , Correia J. 
Published: August 2017

AbstractWhile radiosondes have provided atmospheric scientists an accurate high-vertical-resolution profile of the troposphere for decades, they are unable to provide high-temporal-resolution observations without significant recurring expenses. Remote sensing technology, however, has the ability to monitor the evolution of the atmosphere in unprecedented detail. One particularly promising tool is the Atmospheric Emitted Radiance Interferometer (AERI), a passive ground-based infrared radiometer. Through a physical retrieval, the AERI can retrieve the vertical profile of temperature and humidity at a temporal resolution on the order of minutes. The synthesis of these two instruments may provide an improved diagnosis of the processes occurring in the atmosphere. This study provides a better understanding of the capabilities of the AERI in environments supportive of deep, moist convection. Using 3-hourly radiosonde launches and thermodynamic profiles retrieved from collocated AERIs, this study evaluates the accuracy of AERI-derived profiles over the diurnal cycle by analyzing AERI profiles in both the convective and stable boundary layers. Monte Carlo sampling is used to calculate the distribution of convection indices and compare the impact of measurement errors from each instrument platform on indices. This study indicates that the nonintegrated indices (e.g., lifted index) derived from AERI retrievals are more accurate than integrated indices (e.g., CAPE). While the AERI retrieval’s vertical resolution can inhibit precise diagnoses of capping inversions, the high-temporal-resolution nature of the AERI profiles overall helps in detecting rapid temporal changes in stability.
Comparative Ground Validation of IMERG and TMPA at Variable Spatiotemporal Scales in the Tropical Andes
Authors: Manz Bastian , Páez-Bimos Sebastián , Horna Natalia , Buytaert Wouter , Ochoa-Tocachi Boris , Lavado-Casimiro Waldo , Willems Bram 
Published: August 2017

Abstract
An initial ground validation of the Integrated Multisatellite Retrievals for GPM (IMERG) Day-1 product from March 2014 to August 2015 is presented for the tropical Andes. IMERG was evaluated along with the Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) against 302 quality-controlled rain gauges across Ecuador and Peru. Detection, quantitative estimation statistics, and probability distribution functions are calculated at different spatial (0.1°, 0.25°) and temporal (1 h, 3 h, daily) scales. Precipitation products are analyzed for hydrometeorologically distinct subregions. Results show that IMERG has a superior detection and quantitative rainfall intensity estimation ability than TMPA, particularly in the high Andes. Despite slightly weaker agreement of mean rainfall fields, IMERG shows better characterization of gauge observations when separating rainfall detection and rainfall rate estimation. At corresponding space–time scales, IMERG shows better estimation of gauge rainfall probability distributions than TMPA. However, IMERG shows no improvement in both rainfall detection and rainfall rate estimation along the dry Peruvian coastline, where major random and systematic errors persist. Further research is required to identify which rainfall intensities are missed or falsely detected and how errors can be attributed to specific satellite sensor retrievals. The satellite–gauge difference was associated with the point-area difference in spatial support between gauges and satellite precipitation products, particularly in areas with low and irregular gauge network coverage. Future satellite–gauge evaluations need to identify such locations and investigate more closely interpixel point-area differences before attributing uncertainties to satellite products.
Dropsonde Observations of Total Integrated Water Vapor Transport within North Pacific Atmospheric Rivers
Authors: Ralph F. M. , Iacobellis S. F. , Neiman P. J. , Cordeira J. M. , Spackman J. R. , Waliser D. E. , Wick G. A. , White A. B. , Fairall C. 
Published: August 2017

Abstract
Aircraft dropsonde observations provide the most comprehensive measurements to date of horizontal water vapor transport in atmospheric rivers (ARs). The CalWater experiment recently more than tripled the number of ARs probed with the required measurements. This study uses vertical profiles of water vapor, wind, and pressure obtained from 304 dropsondes across 21 ARs. On average, total water vapor transport (TIVT) in an AR was 4.7 × 108 ± 2 × 108 kg s−1. This magnitude is 2.6 times larger than the average discharge of liquid water from the Amazon River. The mean AR width was 890 ± 270 km. Subtropical ARs contained larger integrated water vapor (IWV) but weaker winds than midlatitude ARs, although average TIVTs were nearly the same. Mean TIVTs calculated by defining the lateral “edges” of ARs using an IVT threshold versus an IWV threshold produced results that differed by less than 10% across all cases, but did vary between the midlatitudes and subtropical regions.
Current State of Overlapping, Concurrent, and Multiple‐Room Surgery in Otolaryngology: A National Survey
Authors: Cognetti David M. , Nussenbaum Brian , Brenner Michael J. , Chi David H. , McCormick Michael E. , Venkatraman Giri , Zhan Tingting , McKinlay Alex J. 
Published: August 2017

ObjectiveMultiple‐room surgery has gained attention due to reports in the lay press scrutinizing the activity, with hospitals and the government collecting data on current practice. We studied practices and attitudes toward multiple‐room surgery in otolaryngology.MethodsA survey was developed by members of the Patient Safety and Quality Improvement Committee of the American Academy of Otolaryngology—Head and Neck Surgery. The survey was distributed to members of the Academy and included questions on demographics, current practices, and opinions regarding multiple‐room surgery. The survey was designed to capture the spectrum of multidisciplinary, overlapping, and simultaneous/concurrent surgery practices. Data were collected via SurveyMonkey.ResultsA total of 907 of 9520 members completed the survey. Of the respondents, 40.4% reported performing some form of multiple‐room surgery. Multiple‐room surgery is more common amongst subspecialists than general otolaryngologists. Most believed that regulations disallowing multiple‐room surgery would result in an increase in late starts (73.5%), an increase in the time to schedule surgery (84.5%), a detriment to residency training (63.1%), and no improvement in patient safety (60%.)DiscussionMultiple‐room surgery is common among responding otolaryngologists. Most respondents consider the practice to serve a role in facilitating access, efficiency, and training.Implications for PracticeDue to recent attention placed on multiple‐room surgery, institutions are reviewing policies regarding the practice. This survey suggests that policy changes that restrict multiple‐room surgery must consider a potential unintended negative impact on patient care and access.
Prevalence and characteristics of prisoners requiring end-of-life care: A prospective national survey
Authors: Pazart Lionel , Godard-Marceau Aurélie , Chassagne Aline , Vivot-Pugin Aurore , Cretin Elodie , Amzallag Edouard , Aubry Regis 
Published: August 2017

Background: Ensuring adequate end-of-life care for prisoners is a critical issue. In France, data investigating the impact of laws allowing release of seriously ill prisoners are lacking. Aim: To assess the number and characteristics of prisoners requiring palliative care in French prisons. Design: A prospective, national survey collecting data over a 3-month period. Setting/participants: All healthcare units ( n = 190) providing care for prisoners in France. The prison population was 66,698 during the study period. Data collection concerned prisoners requiring end-of-life care, that is, with serious, advanced, progressive, or terminal illness and life expectancy <1 year. Results: Estimated annual prevalence of ill prisoners requiring end-of-life care was 15.2 (confidence interval: 12.5–18.3) per 10,000 prisoners. The observed number of prisoners requiring palliative care ( n = 50) was twice as high as the expected age- and sex-standardized number based on the general population and similar to the expected number among persons 10 years older in the free community. In all, 41 of 44 (93%) of identified ill prisoners were eligible for temporary or permanent compassionate release, according to their practitioner. Only 33 of 48 (68%) of ill prisoners requested suspension or reduction in their sentence on medical grounds; half (16/33) received a positive answer. Conclusion: The proportion of prisoners requiring palliative care is higher than expected in the general population. The general frailty and co-existing conditions of prisoners before incarceration and the acceleration of these phenomena in prison could explain this increase in end-of-life situations among prisoners.
Role of ultrasound in the assessment of percutaneous laser ablation of cervical metastatic lymph nodes from thyroid carcinoma
Authors: Zhang Lu , Zhou Wei , Zhan WeiWei 
Published: August 2017

Background Few studies have examined the feasibility and efficiency of performing ultrasound and contrast-enhanced ultrasound (CEUS) after percutaneous laser ablation (PLA) of cervical metastatic lymph nodes from thyroid cancer. Purpose To investigate and describe the use of conventional ultrasound and CEUS in evaluating PLA of metastatic lymph nodes. Material and Methods PLA was performed in a small, prospective, observational study of 21 metastatic lymph nodes in 17 thyroid cancer patients who underwent radical thyroid resection. CEUS was conducted prior to PLA and 1 h and seven days after ablation. Conventional ultrasound examination of all nodes was performed during follow-up after ablation. We observed contrast agent perfusion in the lymph nodes, calculated perfusion defect volumes using CEUS and determined the rates of reduction for metastatic lymph nodes for a mean duration of 17.86 ± 4.704 months (range = 12–27 months). Results CEUS demonstrated that the perfusion defect volume was larger on day 7 than on day 1 post-ablation in 47% of the ablated nodes. Compared to the largest diameters and volumes pre-PLA, the corresponding post-PLA values significantly decreased ( P < 0.05 versus baseline). No statistically significant change in thyroglobulin (Tg) levels before and after PLA was observed in this study ( P > 0.05 versus baseline). Conclusion CEUS can be effectively used to distinguish the margins of ablated regions, assess the accuracy of PLA, and monitor short-term changes in necrotic areas. However, long-term follow-up assessments of the curative effect of PLA will predominantly rely on conventional ultrasonography.
Diagnostic performances of supplemental breast ultrasound screening in women with personal history of breast cancer
Authors: Song Sung Eun , Cho Nariya , Chang Jung Min , Chu A Jung , Yi Ann , Moon Woo Kyung 
Published: August 2017

Background Supplemental breast ultrasonography (US) has been used as a surveillance imaging method in women with personal history of breast cancer (PHBC). However, there have been limited data regarding diagnostic performances. Purpose To evaluate diagnostic performances of supplemental breast US screening for women with PHBC and to compare with those for women without PHBC. Material and Methods Between 2011 and 2012, 12,230 supplemental US exams were performed in 12,230 women with negative mammograms: 6584 women with PHBC and 5646 women without PHBC. Cancer detection rate, interval cancer rate, abnormal interpretation rate, positive predictive values (PPVs), sensitivity, and specificity were calculated and compared. Results Overall cancer detection rate and first-year interval cancer rate were 1.80/1000 exams and 0.91/1000 negative exams, both of which were higher in women with PHBC than in women without PHBC (2.88 vs. 0.53 per 1000, P = 0.003; 1.50 vs. 0.20 per 1000, P = 0.027). Abnormal interpretation rate was lower in the women with PHBC than in women without PHBC (9.1% vs. 12.1%, P < 0.001). Sensitivity was not different (67.9% vs. 75.0%, P = 1.000), whereas specificity and PPV3 were higher in women with PHBC than in women without PHBC (91.2% vs. 88.0%, P < 0.001; 22.6% vs. 3.1%, P < 0.001). The majority of detected cancers in women with PHBC (78.9%, 15/19) were stage 0 or 1. Conclusion Supplemental breast US screening increases early stage second breast cancers with high specificity and PPV3 in women with PHBC, however, high interval cancer rate in younger women with PHBC should be noted.
Ultra-low-dose lung screening CT with model-based iterative reconstruction: an assessment of image quality and lesion conspicuity
Authors: Ju Yun Hye , Lee Geewon , Lee Ji Won , Hong Seung Baek , Suh Young Ju , Jeong Yeon Joo 
Published: August 2017

Background Reducing radiation dose inevitably increases image noise, and thus, it is important in low-dose computed tomography (CT) to maintain image quality and lesion detection performance. Purpose To assess image quality and lesion conspicuity of ultra-low-dose CT with model-based iterative reconstruction (MBIR) and to determine a suitable protocol for lung screening CT. Material and Methods A total of 120 heavy smokers underwent lung screening CT and were randomly and equally assigned to one of five groups: group 1 = 120 kVp, 25 mAs, with FBP reconstruction; group 2 = 120 kVp, 10 mAs, with MBIR; group 3 = 100 kVp, 15 mAs, with MBIR; group 4 = 100 kVp, 10 mAs, with MBIR; and group 5 = 100 kVp, 5 mAs, with MBIR. Two radiologists evaluated intergroup differences with respect to radiation dose, image noise, image quality, and lesion conspicuity using the Kruskal–Wallis test and the Chi-square test. Results Effective doses were 61–87% lower in groups 2–5 than in group 1. Image noises in groups 1 and 5 were significantly higher than in the other groups ( P < 0.001). Overall image quality was best in group 1, but diagnostic acceptability of overall image qualities in groups 1–3 was not significantly different (all P values > 0.05). Lesion conspicuities were similar in groups 1–4, but were significantly poorer in group 5. Conclusion Lung screening CT with MBIR obtained at 100 kVp and 15 mAs enables a ∼60% reduction in radiation dose versus low-dose CT, while maintaining image quality and lesion conspicuity.
Aeroplane headache, mountain descent headache, diving ascent headache.. Three subtypes of headache attributed to imbalance between intrasinusal and external air pressure?
Authors: Mainardi Federico , Maggioni Ferdinando , Zanchin Giorgio 
Published: August 2017

Background Headache attributed to aeroplane travel (AH) is currently codified in Chapter 10.1.2 of the International Classification of Headache Disorders 3 beta (ICHD 3 beta). After our previous papers, the investigation was enlarged to 200 patients. Material and methods People affected by AH contacted us by mail and agreed to fill in a detailed anonymous questionnaire that allowed a thorough definition of the headache features. Results This extended case series allows us to confirm most of the clinical features of AH, reported in our previously published article, and to partially modify others. New results mainly regard the higher occurrence of accompanying symptoms and the presence of a long lasting mild headache phase, usually not exceeding 24 h, that follows the short lasting acute pain, the duration of which has been confirmed as less than 30 min. Moreover, headache attacks identical to those of AH are reported in a portion of patients, triggered by the ascent during free/snorkeling or scuba diving and rapid descent from high mountains. Conclusion The coexistence of AH with headache triggered by different environmental factors (ascent during free/scuba diving and descent from high mountains) indicates a common causal mechanism, that is, the imbalance between intrasinusal and external air pressure. We propose to classify them together, within Chapter 10 “ Headache attributed to disorders of homoeostasis”, under a unique heading “ Headache attributed to imbalance between intrasinusal and external air pressure”.