bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time Savings Using a Standardized Glucose Reporting System and Ambulatory Glucose Profile
Authors: Mullen Deborah M. , Bergenstal Richard , Criego Amy , Arnold Kathleen Cecilia , Goland Robin , Richter Sara 
Published: November 2017

Background: Diabetes care is predominately done at home by the patient. When clinics do not have a reliable, easy process for obtaining this patient data, clinical decisions must be made with incomplete verbal recall reports. Unused or inaccessible glucose data represent a large information gap affecting clinical decision making. This study’s purpose was to design an optimized glucose device download system with a standardized report and to evaluate its efficiency. Methods: Observations and evaluations of glucose data retrieval occurred at two clinics; an additional clinic utilized the optimized process doing only post process timings. Patients/families and clinicians were surveyed about their experiences with the system and the standardized report (AGP). The study was approved by all the sites’ IRBs. Results: Optimized systems saved staff at least 3 min per patient. Standardized AGP reports and an optimized data system made the work flow of glucose data easier to complete. The AGP report was preferred by patients, families, and clinicians. Conclusions: An optimized system takes advantage of patient lobby downtime to download glucose devices and ensures that diabetes clinical decisions are made utilizing all available data. Staff and patients liked the software lobby system and found it a valuable time-saving tool.
ADC quantification in basilar artery occlusion as an indicator of clinical outcome after endovascular treatment
Authors: Pereira Daniela , Fragata Isabel , Amorim José , Reis João 
Published: November 2017

Background Acute ischemic stroke due to basilar artery occlusion (BAO) is associated with a dismal prognosis and, even though endovascular treatment (EVT) contributed to an improvement in clinical outcomes, patient selection is difficult and frequently results in futile recanalization. We investigated the prognostic value of baseline ADC quantification in patients with BAO undergoing EVT. Methods We retrospectively evaluated MRI at admission in 11 patients with BAO undergoing EVT. Ischemic lesions were defined on baseline DWI and minimum ADC (minADC), ADC ratio and total area were quantified. Final infarction area was determined on follow-up T2WI/CT. We assessed the correlation between imaging parameters, recanalization grade and clinical scores (NIHSS at admission, NIHSS and mRS at discharge and mRS at three months) using Spearman rank correlation coefficient and correcting for multiple comparisons with the false discovery rate (FDR). Results Lower values of minADC at admission MRI are strongly correlated with higher scores in NIHSS (rs = −0.845, p = 0.001) and mRS at discharge (rs = −0.743, p = 0.009). We also found a negative correlation between minADC and NIHSS at admission (rs = −0.67, p = 0.02), mRS at three months and difference between pre- and post-treatment ischemic area (rs = −0.664, p = 0.026) that lost significance with FDR correction. Ischemic area and TICI grade were not significantly associated with clinical results. Conclusions ADC quantification of ischemic lesions at baseline MRI seems to predict clinical outcome in patients with BAO undergoing EVT, more importantly than ischemic area or TICI grade.
Comparison of normal facial nerve enhancement at 3T MRI using gadobutrol and gadopentetate dimeglumine
Authors: Radhakrishnan Rupa , Ahmed Shamima , Tilden Joshua Cole , Morales Humberto 
Published: November 2017

Background and purpose The facial nerve is unique among cranial nerves in demonstrating normal enhancement of particular segments. The effect of varying T1 relaxivities of gadolinium-based contrast agents on facial nerve enhancement is unclear. In this study, we assess differences in normal facial nerve enhancement with two different gadolinium-based contrast agents, gadobutrol and gadopentetate dimeglumine. In addition, we evaluate differences in facial nerve enhancement with spin-echo (SE) T1 versus 3D inversion recovery prepared fast spoiled gradient-echo (FSPGR) post-contrast sequences. Methods A total of 140 facial nerves in 70 individuals were evaluated (70 with gadobutrol and 70 with gadopentetate dimeglumine) by two blinded reviewers. Differences in enhancement of facial nerve segments between the two agents were analyzed. Differences in enhancement between SE T1 and FSPGR imaging were also evaluated. Results There was no significant difference in facial nerve enhancement between gadobutrol and gadopentetate dimeglumine. Enhancement was commonly observed in the geniculate, tympanic and mastoid segments (98%–100%) with either contrast agent; enhancement was less common in the labyrinthine segments (9%–14%) and lateral canalicular segment (2%–5%). There was a smaller enhancing proportion of labyrinthine and tympanic segments with FSPGR as compared to SE T1 images with gadobutrol. Conclusion There is no significant difference in overall enhancement of the facial nerve between gadobutrol and gadopentetate dimeglumine. Mild enhancement of the lateral canalicular portion of the facial nerve may be a normal finding. With FSPGR sequence, there is lesser perceived enhancement of the labyrinthine and tympanic segments of the facial nerve with gadobutrol.
Fitness attenuates the prevalence of increased coronary artery calcium in individuals with metabolic syndrome
Authors: Ekblom-Bak Elin , Ekblom Örjan , Fagman Erika , Angerås Oskar , Schmidt Caroline , Rosengren Annika , Börjesson Mats , Bergström Göran 
Published: November 2017

Background The association between cardiorespiratory fitness, physical activity and coronary artery calcium (CAC) is unclear, and whether higher levels of fitness attenuate CAC prevalence in subjects with metabolic syndrome is not fully elucidated. The present study aims to: a) investigate the independent association of fitness on the prevalence of CAC, after adjustment for moderate-to-vigorous physical activity and sedentary time, and b) study the possible attenuation of increased CAC by higher fitness, in participants with metabolic syndrome. Design Cross-sectional. Methods In total 678 participants (52% women), 50–65 years old, from the SCAPIS pilot study were included. Fitness (VO2max) was estimated by submaximal cycle ergometer test and moderate-to-vigorous physical activity and sedentary time were assessed using hip-worn accelerometers. CAC score (CACS) was quantified using the Agatston score. Results The odds of having a significant CACS (≥100) was half in participants with moderate/high fitness compared with their low fitness counterparts. Further consideration of moderate-to-vigorous physical activity, sedentary time and number of components of the metabolic syndrome did only slightly alter the effect size. Those with metabolic syndrome had 47% higher odds for significant CAC compared with those without metabolic syndrome. However, moderate/high fitness seems to partially attenuate this risk, as further joint analysis indicated an increased odds for having significant CAC only in the unfit metabolic syndrome participants. Conclusions Being fit is associated with a reduced risk of having significant CAC in individuals with metabolic syndrome. While still very much underutilized, fitness should be taken into consideration in everyday clinical risk prediction in addition to the traditional risk factors of the metabolic syndrome.
ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage
Authors: Karayazi Atici Ödül , Urbanska Anna , Gopinathan Sesha Gopal , Boutillon Florence , Goffin Vincent , Shemanko Carrie S 
Published: November 2017

AbstractProlactin (PRL) acts as a survival factor for breast cancer cells, but the PRL signaling pathway and the mechanism are unknown. Previously, we identified the master chaperone, heat shock protein 90 (HSP90) α, as a prolactin–Janus kinase 2 (JAK2)–signal transducer and activator of transcription 5 (STAT5) target gene involved in survival, and here we investigated the role of HSP90 in the mechanism of PRL-induced viability in response to DNA damage. The ataxia–telangiectasia mutated kinase (ATM) protein plays a critical role in the cellular response to double-strand DNA damage. We observed that PRL increased viability of breast cancer cells treated with doxorubicin or etoposide. The increase in cellular resistance is specific to the PRL receptor, because the PRL receptor antagonist, Δ1-9-G129R-hPRL, prevented the increase in viability. Two different HSP90 inhibitors, 17-allylamino-17-demethoxygeldanamycin and BIIB021, reduced the PRL-mediated increase in cell viability of doxorubicin-treated cells and led to a decrease in JAK2, ATM, and phosphorylated ATM protein levels. Inhibitors of JAK2 (G6) and ATM (KU55933) abolished the PRL-mediated increase in cell viability of DNA-damaged cells, supporting the involvement of each, as well as the crosstalk of ATM with the PRL pathway in the context of DNA damage. Drug synergism was detected between the ATM inhibitor (KU55933) and doxorubicin and between the HSP90 inhibitor (BIIB021) and doxorubicin. Short interfering RNA directed against ATM prevented the PRL-mediated increase in cell survival in two-dimensional cell culture, three-dimensional collagen gel cultures, and clonogenic cell survival, after doxorubicin treatment. Our results indicate that ATM contributes to the PRL–JAK2–STAT5–HSP90 pathway in mediating cellular resistance to DNA-damaging agents.
The effect of the use of systematic teaching method on students’ success in the process of violoncello education<p>Viyolonsel eğitimi sürecinde dizgeli öğretim modelinin öğrenci başarısına etkisi
Authors: Şen Çağrı , Özdemir Mehmet Ali 
Published: November 2017

This study was conducted to examine the effect of the use of systematic teaching method in fine arts high school violoncello education lessons on students’ academic success in terms of cognitive and psychomotor skills. In this study, the pretest-posttest control group experimental pattern was used. The study was carried out with a sample of 14 violoncello students studying at Bursa Zeki Müren Fine Arts High School, 7 in the experimental group and 7 in the control group. In the scope of this study, a syllabus for 8 weeks (16 hours) was prepared based on systematic teaching method so as to improve the cognitive and psychomotor learning levels of the students. In order to gain the data, two scales were developed by the researcher aimed at cognitive field and psychomotor field. Whereas the experimental group was applied a syllabus based on systematic teaching for 8 weeks, the control group was applied the traditional method which was being used at school. The data obtained from pretest and posttest were analyzed with statistical methods. In accordance with the data gained from the research, the findings can be summarized as the following: A meaningful difference in favour of the experimental group was found between experimental group to which systematic teaching method was applied and the control group to which traditional method was applied in terms of both the knowledge level and the skill level of performance.Extended English abstract is in the end of Full Text PDF (TURKISH) file. ÖzetBu araştırmada, güzel sanatlar liselerinde dizgeli öğretim modeline göre yapılandırılmış viyolonsel eğitimi dersinin, bilgi düzeyi ve performansa ilişkin beceriler bakımından öğrencilerin akademik başarılarına etkisini belirlemek amaçlanmıştır. Öntest-sontest kontrol gruplu deneysel desene uygun düzenlenen araştırmanın örneklemini, Bursa Zeki Müren Güzel Sanatlar Lisesi’nde öğrenim gören, deney grubunda 7 ve kontrol grubunda 7 olmak üzere 14 viyolonsel öğrencisi oluşturmuştur. Viyolonsel öğrencilerinin bilgi düzeylerini ve performansa yönelik beceri düzeylerini arttırmak amacıyla, dizgeli öğretim modeline dayalı 8 haftalık (16 ders saati) süreyi kapsayan ders planı hazırlanmıştır. Araştırma verilerini elde etmek üzere, bilişsel ve devinişsel alana yönelik iki tür ölçek geliştirilmiştir. 8 hafta süreyle deney grubuna dizgeli öğretim modeline dayalı viyolonsel eğitimi uygulanırken, kontrol grubunda geleneksel öğretim sürdürülmüştür. Öntest ve sontestten elde edilen veriler istatistiksel analizlerle çözümlenmiştir. Araştırmadan elde edilen bulgular şöyle özetlenebilir: Dizgeli öğretim modelinin uygulandığı deney grubu ile geleneksel öğretim yapılan kontrol grubu arasında, hem bilgi düzeyi hem de performansa ilişkin beceri düzeyi bakımından deney grubu lehine anlamlı farklılık bulunmuştur.
A Speech on “Why Accounting Matters: A Central Bank Perspective”
Authors: Schwarz Claudia 
Published: November 2017

Abstract
This article is the transcript of a speech given at the international workshop on “Which accounting regulation for Europe’s economy and society?” held at the European Parliament, Strasbourg, on May 20, 2015. This speech is based on the work summarised in “Schwarz et al., 2015. ‘Why accounting matters: A central bank perspective’. Accounting, Economics and Law: A Convivium.”.
Role of anodic oxide films in the corrosion of aluminum and its alloys
Authors: Takahashi Hideaki , Chiba Makoto 
Published: November 2017

Abstract
Anodic oxide films on aluminum are classified into two groups: porous-type anodic oxide films (PAOF) and barrier-type anodic oxide films (BAOF). The present paper is a review of the corrosion of pure aluminum (Al) and Al alloys covered with PAOF and BAOF, focusing on the role of anodic oxide films in the process of corrosion. Several topics are discussed in detail, including (a) changes in the dissolution mode of PAOF in acidic media by pore sealing, (b) hydration and dissolution of BAOF in pure water and neutral solutions containing organic and inorganic electrolytes, (c) pitting corrosion during the cathodic polarization of Al covered with PAOF and BAOF, (d) corrosion of PAOF-covered Al/Bi/Sn alloys in alcohols at 142°C, and (e) synergistic effects of Cl− and Cu2+ ions in the corrosion of PAOF-covered Al alloys in aqueous solutions.
Laser marking as environment technology
Authors: Sobotova Lydia , Badida Miroslav 
Published: November 2017

AbstractThe contribution deals with the laser marking as one of the progressive and environment friendly technologies with utilisation in many branches of industry. Engraving and other types of laser marking of different types of materials are very actual technologies these days. Laser marking decreases the waste creation in comparison with the other classical marking technologies, which use paintings or created chips. In this experimental investigation the laser marking surface texturing of material AL99,7 according to STN 42 4003:1993-08 (STN EN 573) has been conducted. The laser marking machine TruMark 6020 and software TruTops Mark were used. Laser surface texturing after laser marking has been realised under different combinations of process parameters: pulse frequency, pulse energy and laser beam scanning speed. The morphological characterization of engraving or annealing surfaces has been performed using scanning electron microscopy (SEM) technique. The evaluation of roughness of engraved surfaces has been realized according to STN EN ISO 4287 by using Surftest SJ 301. The aim of the contribution was to show how different laser parameters affect the surface texture and colour change of metallic materials while creating minimal waste.
Jessie Weston and the Ancient Mystery of Arthurian Romance
Authors: Wood Juliette 
Published: November 2017

Abstract
This article presents a survey of the work of Jessie Weston and examines her role in the development of Arthurian studies in the first half of the twentieth century. In her considerable output of articles, editions, and retellings of Arthurian romance tales, Weston attempted to establish links between major themes in medieval Arthurian romances and the ancient traditions of the Celts. These speculations reached their height in her most famous and most controversial book, From Ritual to Romance, where she suggested that the origins of the medieval Grail story could be traced back to an initiation ritual in an ancient mystery cult that survived into the medieval period. Although From Ritual to Romance has influenced modernist literature and culture, current Arthurian scholarship has largely rejected Weston’s theories about the relationship between Celtic civilization and romance. However, the popularity surrounding this controversial work, especially outside mainstream scholarship, has obscured Weston’s other work, and the present study is intended to present a wider context for her achievements and to examine their contribution to the study of Arthurian tradition at the beginning of the twentieth century.
The photon identification loophole in EPRB experiments: computer models with single-wing selection
Authors: De Raedt Hans , Michielsen Kristel , Hess Karl 
Published: November 2017

Abstract
Recent Einstein-Podolsky-Rosen-Bohm experiments [M. Giustina et al. Phys. Rev. Lett. 115, 250401 (2015); L. K. Shalm et al. Phys. Rev. Lett. 115, 250402 (2015)] that claim to be loophole free are scrutinized. The combination of a digital computer and discrete-event simulation is used to construct a minimal but faithful model of the most perfected realization of these laboratory experiments. In contrast to prior simulations, all photon selections are strictly made, as they are in the actual experiments, at the local station and no other “post-selection” is involved. The simulation results demonstrate that a manifestly non-quantum model that identifies photons in the same local manner as in these experiments can produce correlations that are in excellent agreement with those of the quantum theoretical description of the corresponding thought experiment, in conflict with Bell’s theorem which states that this is impossible. The failure of Bell’s theorem is possible because of our recognition of the photon identification loophole. Such identification measurement-procedures are necessarily included in all actual experiments but are not included in the theory of Bell and his followers.
The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization
Authors: Khatri Natasha , Gilbert James P. , Huo Yuda , Sharaflari Roozhin , Nee Michael , Qiao Hui , Man Heng-Ye 
Published: November 2017

UBE3Agene copy number variation and the resulting overexpression of the protein E6AP is directly linked to autism spectrum disorders (ASDs). However, the underlying cellular and molecular neurobiology remains less clear. Here we report the role of ASD-related increased dosage of Ube3A/E6AP in dendritic arborization during brain development. We show that increased E6AP expression in primary cultured neurons leads to a reduction in dendritic branch number and length. The E6AP-dependent remodeling of dendritic arborization results from retraction of dendrites by thinning and fragmentation at the tips of dendrite branches, leading to shortening or removal of dendrites. This remodeling effect is mediated by the ubiquitination and degradation of XIAP (X-linked inhibitors of aptosis protein) by E6AP, which leads to activation of caspase-3 and cleavage of microtubules.In vivo, male and femaleUbe3A2X ASD mice show decreased XIAP levels, increased caspase-3 activation, and elevated levels of tubulin cleavage. Consistently, dendritic branching and spine density are reduced in cortical neurons ofUbe3A2X ASD mice. In revealing an important role for Ube3A/E6AP in ASD-related developmental alteration in dendritic arborization and synapse formation, our findings provide new insights into the pathogenesis of Ube3A/E6AP-dependent ASD.SIGNIFICANCE STATEMENTCopy number variation of theUBE3Agene and aberrant overexpression of the gene product E6AP protein is a common cause of autism spectrum disorders (ASDs). During brain development, dendritic growth and remodeling play crucial roles in neuronal connectivity and information integration. We found that in primary neurons and in Ube3A transgenic autism mouse brain, overexpression of E6AP leads to significant loss of dendritic arborization. This effect is mediated by the ubiquitination of XIAP (X-linked inhibitor of aptosis protein) by E6AP, subsequent activation of caspases, and the eventual cleavage of microtubules, leading to local degeneration and retraction at the tips of dendritic branches. These findings demonstrate dysregulation in neuronal structural stability as a major cellular neuropathology in ASD.
Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery
Authors: Femenía Teresa , Giménez-Cassina Alfredo , Codeluppi Simone , Fernández-Zafra Teresa , Katsu-Jiménez Yurika , Terrando Niccolò , Eriksson Lars I. , Gómez-Galán Marta 
Published: November 2017

Immune-related events in the periphery can remotely affect brain function, contributing to neurodegenerative processes and cognitive decline. In mice, peripheral surgery induces a systemic inflammatory response associated with changes in hippocampal synaptic plasticity and transient cognitive decline, however, the underlying mechanisms remain unknown. Here we investigated the effect of peripheral surgery on neuronal-glial function within hippocampal neuronal circuits of relevance to cognitive processing in male mice at 6, 24, and 72 h postsurgery. At 6 h we detect the proinflammatory cytokine IL-6 in the hippocampus, followed up by alterations in the mRNA and protein expression of astrocytic and neuronal proteins necessary for optimal energy supply to the brain and for the reuptake and recycling of glutamate in the synapse. Similarly, at 24 h postsurgery the mRNA expression of structural proteins (GFAP and AQP4) was compromised. At this time point, functional analysis in astrocytes revealed a decrease in resting calcium signaling. Examination of neuronal activity by whole-cell patch-clamp shows elevated levels of glutamatergic transmission and changes in AMPA receptor subunit composition at 72 h postsurgery. Finally, lactate, an essential energy substrate produced by astrocytes and critical for memory formation, decreases at 6 and 72 h after surgery. Based on temporal parallels with our previous studies, we propose that the previously reported cognitive decline observed at 72 h postsurgery in mice might be the consequence of temporal hippocampal metabolic, structural, and functional changes in astrocytes that lead to a disruption of the neuroglial metabolic coupling and consequently to a neuronal dysfunction.SIGNIFICANCE STATEMENTA growing body of evidence suggests that surgical trauma launches a systemic inflammatory response that reaches the brain and associates with immune activation and cognitive decline. Understanding the mechanisms by which immune-related events in the periphery can influence brain processes is essential for the development of therapies to prevent or treat postoperative cognitive dysfunction and other forms of cognitive decline related to immune-to-brain communication, such as Alzheimer's and Parkinson's diseases. Here we describe the temporal orchestration of a series of metabolic, structural, and functional changes after aseptic trauma in mice related to astrocytes and later in neurons that emphasize the role of astrocytes as key intermediaries between peripheral immune events, neuronal processing, and potentially cognition.