bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It’s Like This One Man’s Baby”: Gender and Decision-Making Power in Sport for Development and Peace Organizations
Authors: Piggott Lucy V. 
Published: October 2024

Within this article, the author draws on Rao et al.’s theory of the deep structure of organizations to analyze the extent to which decision-making power across sport for development and peace organizations is gender inclusive. Findings from interviews with women and men leaders indicate that decision-making power across the organizations is inclusive to women, with women holding positional power and having a voice to influence. However, the author emphasizes that caution must be taken in claiming that such decision-making power is fully gender inclusive. This is because “women” in positions of power mostly represent privileged profiles, and men hold the most powerful positions. These findings are strongly linked to the origin stories of the organizations, with all having men (co)founders. The gendered implications of such men-dominated organizational histories were found to span both inward- and outward-facing organizational elements and were reported to be difficult to challenge.
Multisite community-scale monitoring of respiratory and enteric viruses in the effluent of a nursing home and in the inlet of the local wastewater treatment plant
Authors: Manoha Catherine , Dequiedt Anne-Laure , Thery Lucie , Marotel Marina , Pez Floriane , Vouillon Bruno , Gueneau Eric , de Rougemont Alexis 
Published: October 2024

ABSTRACT

The aim of this study was to evaluate whether community-level monitoring of respiratory and enteric viruses in wastewater can provide a comprehensive picture of local virus circulation. Wastewater samples were collected weekly at the wastewater treatment plant (WWTP) inlet and at the outlet of a nearby nursing home (NH) in Burgundy, France, during the winter period of 2022/2023. We searched for the pepper mild mottle virus as an indicator of fecal content as well as for the main respiratory viruses [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, and respiratory syncytial virus] and enteric viruses (rotavirus, sapovirus, norovirus, astrovirus, and adenovirus). Samples were analyzed using real-time reverse transcription PCR-based methods. SARS-CoV-2 was the most frequently detected respiratory virus, with 66.7% of positive samples from the WWTP and 28.6% from the NH. Peaks of SARS-CoV-2 were consistent with the chronological incidence of infections recorded in the sentinel surveillance and the nearby hospital databases. The number of positive samples was lower in the NH than in WWTP for the three respiratory viruses. Enteric viruses were frequently detected, most often sapovirus and norovirus genogroup II, accounting both for 77.8% of positive samples in the WWTP and 57.1% and 37%, respectively, in the NH. The large circulation of sapovirus was unexpected in particular in the NH. Combined wastewater surveillance using simple optimized methods can be a valuable tool for monitoring viral circulation and may serve as a suitable early warning system for identifying both local outbreaks and the onset of epidemics. These results encourage the application of wastewater-based surveillance (WBS) to SARS-CoV2, norovirus, and sapovirus.

IMPORTANCE
WBS provides valuable information on the spread of epidemic viruses in the environment using appropriate and sensitive detection methods. By monitoring the circulation of viruses using reverse transcription PCR methods in wastewater from the inlet of a wastewater treatment plant and the outlet of a nearby retirement home (connected to the same collective sewer network), we aimed to demonstrate that implementing combined WBS at key community sites allows effective detection of the occurrence of respiratory (influenza, respiratory syncytial virus, and SARS-CoV-2) and enteric (norovirus, rotavirus, and sapovirus) virus infections within a given population. This analysis on a localized scale provided new information on the viral circulation in the two different sites. Implementing WBS to monitor the circulation or the emergence of infectious diseases is an important means of alerting the authorities and improving public health management. WBS could participate actively to the health of humans, animals, and the environment.
The mammary glands of cows abundantly display receptors for circulating avian H5 viruses
Authors: Ríos Carrasco María , Gröne Andrea , van den Brand Judith M. A. , de Vries Robert P. 
Published: October 2024

ABSTRACT

Influenza A viruses (IAVs) from the H5N1 2.3.4.4b clade are circulating in dairy farms in the USA.; ruminants were presumed not to be hosts for IAVs. Previously, IAV-positive mammalian species were hunters and scavengers, possibly getting infected while feeding on infected birds. It is now recognized that H5N1 viruses that circulate in US dairy cattle transmit through a mammary gland route, in contrast to transmission by aerosols via the respiratory tract. The sialome in the cow mammary and respiratory tract is so far solely defined using plant lectins. Here, we used recombinant HA proteins representing current circulating and classical H5 viruses to determine the distribution of IAV receptors in the respiratory and mammary tract tissues of cows. We complemented our study by mapping the glycan distribution of the upper and lower respiratory tracts of horses and pigs. Most of the sialome of the cow respiratory tract is lined with sialic acid modifications, such as N-glycolyl and O-acetyl, which are not bound by IAV. Interestingly, the H5 protein representing the cow isolates is bound significantly in the mammary gland, whereas classical H5 proteins failed to do so. Furthermore, whereas the 9-O-acetyl modification is prominent in all tissues tested, the 5-N-glycolyl modification is not, resulting in the display of receptors for avian IAV hemagglutinins. This could explain the high levels of virus found in these tissues and milk, adding supporting data to this virus transmission route.

IMPORTANCE
H5N1 influenza viruses, which usually affect birds, have been found on dairy farms in the USA. Surprisingly, these viruses are spreading among dairy cows, and there is a possibility that they do not spread through the air but through their milk glands. To understand this better, we studied how the virus attaches to tissues in the cow’s respiratory tract and mammary glands using specific viral proteins. We found that the cow-associated virus binds strongly to the mammary glands, unlike older versions infecting birds. This might explain why the virus is found in cow’s milk, suggesting a new way the virus could be spreading.
Adaptations and metabolic evolution of myzozoan protists across diverse lifestyles and environments
Authors: Waller Ross F. , Carruthers Vern B. 
Published: October 2024

SUMMARY
Myzozoans encompass apicomplexans and dinoflagellates that manifest diverse lifestyles in highly varied environments. They show enormous propensity to employ different metabolic programs and exploit different nutrient resources and niches, and yet, they share much core biology that underlies this evolutionary success and impact. This review discusses apicomplexan parasites of medical significance and the traits and properties they share with non-pathogenic myzozoans. These include the versatility of myzozoan plastids, which scale from fully photosynthetic organelles to the site of very select key metabolic pathways. Pivotal evolutionary innovations, such as the apical complex, have allowed myzozoans to shift from predatory to parasitic and other symbiotic lifestyles multiple times in both apicomplexan and dinoflagellate branches of the myzozoan evolutionary tree. Such traits, along with shared mechanisms for nutrient acquisition, appear to underpin the prosperity of myzozoans in their varied habitats. Understanding the mechanisms of these shared traits has the potential to spawn new strategic interventions against medically and veterinary relevant parasites within this grouping.
3D Ordered Li Anode Architectures towards Suppressing Li Dendrites: A Review
Authors: Fei Pei  , Yan Xin’e , Lei Fangchao , Liu Longgang , Yao Songyuan 
Published: October 2024

Abstract
The fast-growing requirements for high-energy-density Li-ion batteries (LIBs) have prompted the research and development of Li-metal batteries (LMBs) because Li metal has a high theoretical specific capacity of 3860 mA h g–1 and a low redox potential (−3.04 v.s. standard hydrogen electrode, SHE). However, the dendrite formation of Li metal during Li plating and stripping has exerted an enormous impedance in its commercial application. Consequently, it is imperative to exploit effective strategies to eliminate the existing issues. Three-dimensional (3D) ordered Li anode architectures with large surface area and void space, which are capable of lowering the surface current density and affording confined space to accommodate Li plating, consequently suppressing Li dendrite formation and ameliorating undesirable volume changes. More importantly, its well-aligned micro-channels can provide fast pathways for Li ion transport and promote uniform Li plating. Therefore, fabricating 3D ordered architectures is expected to remarkably boost the electrochemical stability and performance of Li anode during cycling. Herein, the important researches on the design of 3D ordered Li anode architectures for LIBs, including flexible anode, are summarized in detail. Emphasis is laid on illuminating the mechanism and the correlation between the 3D-ordered Li microstructures and the electrochemical performance of the LMBs. Furthermore, challenges and forthcoming opportunities in this promising research field are explicitly indicated. It is anticipated that this review could afford a beneficial reference to initiate further innovation in research and development of practical 3D Li anode for high-energy and safe LMBs.
Application of Kolcaba’s Comfort Theory in healthcare promoting adults’ comfort: a scoping review
Authors: Lin Yanxia , Zhou Yi , Chen Can , Yan Chuchu , Gu Junyi 
Published: October 2024

BackgroundComfort is a primary goal of healthcare. Theory-informed interventions and measurement are essential for comfort enhancement.ObjectivesTo categorise and synthesise the international literature on the application of Kolcaba’s Comfort Theory in research and practice aiming to promote adults’ comfort.Eligibility criteriaPapers reporting the application of Kolcaba’s Comfort Theory on adult participants published in English and Chinese.Sources of evidenceMEDLINE, CINAHL, APA PsycInfo, Embase, AMED, Web of Science, Scopus, The Cochrane Library, JBI EBP Database, CNKI, Wan Fang; grey literature of Google Scholar, Baidu Scholar and The Comfort Line were searched from January 1991 to January 2024.Chart methodsFollowing the Joanna Briggs Institute guidance and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist, two reviewers selected papers and extracted data independently using a standardised chart embedded in NVivo software. A thematic synthesis and a descriptive analysis were provided.ResultsThe review included 359 papers. Approximately two-thirds (n=216, 60.2%) had been published since 2017. The majority of papers (n=316, 88.0%) originated from China, the USA, Turkey, Brazil and Portugal. The use of Kolcaba’s Comfort Theory was dominated in a range of hospital settings (n=263) and with participants suffering neoplasms (n=55). Seven categories of theory application were identified: (I) interventions underpinned by Comfort Theory as the theoretical framework, (II) interventions evaluated by instruments derived from Comfort Theory, (III) descriptive or observational studies of services or practices underpinned by Comfort Theory, (IV) surveys using questionnaires derived from Comfort Theory, (V) questionnaires development or adaption based on Comfort Theory, (VI) qualitative studies interpreted by Comfort Theory and (VII) literature reviews and discussion about Comfort Theory use. The most commonly evaluated interventions included music therapy (n=31), position intervention (n=20) and massage (n=19), and the most commonly used questionnaire was General Comfort Questionnaire (n=109).ConclusionsKolcaba’s Comfort Theory has been largely used in interventions and assessments across a wide range of contexts, providing a set of options for practitioners. However, quantifying evidence is needed through further systematic reviews, and continuous development of Comfort Theory is warranted based on the categorisation by this review.
Describing youth participatory evaluation of educational interventions as a key domain of the social determinants of health: protocol for a scoping review
Authors: Montrosse-Moorhead Bianca , Sutter Amanda , Phiri Chisomo , De La Cruz Perdomo Luna 
Published: October 2024

IntroductionYouth participatory evaluationis one model for monitoring global outcomes and assessing interventions to improve young people’s health equity and well-being while embracing principles of participation and empowerment. Little is known about the use of this approach in practise. This scoping review will identify and synthesise descriptions of howyouth participatory evaluationis enacted, to what extent it occurs, and describe the relationship between context and inclusion.Methods and analysisScoping review methods will adhere to those outlined by Arksey and O’Malley. The study will also follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. The review will use publicly available evaluation reports (grey literature) for programmes funded by the US National Science Foundation through the Advancing Informal science, technology, engineering and mathematics (STEM) Learning programme and whose reports are archived in the repository hosted by the Reimagining Equity and Values in Informal STEM education (REVISE) Center. This scoping review is limited to education, one of the domains of the social determinants of health, more precisely STEM education, due to the report publication parameters set by the REVISE Center repository. A research team member will download citations for and PDFs of reports. These citations and reports will be managed using Zotero and exported to Covidence, a web-based program designed to manage systematic and scoping reviews. Evaluation report selection will occur in a two-step process by trained coders with clear criteria. Inclusion criteria will include: (1) report is for an evaluation study; (2) evaluation has a focus on young people, aged 10–24; (3) evaluation is for a programme serving young people, aged 10–24; and (4) report written and uploaded to the REVISE Center repository between 2017 and 2022. All reports hosted on the REVISE Center repository are based in the USA and written in English. Data charting will also be done by trained coders and facilitated by Covidence and a codebook. Several procedures will be used to uphold rigour and consistency during this process. Data analysis will be done with Dedoose.Ethics and disseminationHuman subjects research approval will not be required. This scoping review will rely on publicly available evaluation reports. No human research participants will be involved in this review. Findings will be shared through dissemination strategies, such as peer-reviewed journals, international and national conferences, and social media affiliated with academic institutions and professional associations.Study registrationThis study is preregistered on Open Science Framework (https://osf.io/23jdx/). Registration DOI:https://doi.org/10.17605/OSF.IO/K6J98.
Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational study
Authors: Vasiliadou Ifigenia , Cattaneo Christiana , Chan Phoebe Yuen Ka , Henley-Smith Rhonda , Gregson-Williams Harry , Collins Lisette , Wojewodka Gabriella , Guerrero-Urbano Teresa , Jeannon Jean-Pierre , Connor Steve , Davis Jessica , Pasto Anna , Mustapha Rami , Ng Tony , Kong Anthony 
Published: October 2024

Introduction
Organoids have been successfully used in several areas of cancer research and large living biobanks of patient-derived organoids (PDOs) have been developed from various malignancies. The characteristics of the original tumour tissue such as mutation signatures, phenotype and genetic diversity are well preserved in organoids, thus showing promising results for the use of this model in translational research. In this study, we aim to assess whether we can generate PDOs from head and neck squamous cell carcinoma (HNSCC) samples and whether PDOs can be used to predict treatment sensitivity in HNSCC patients as well as to explore potential biomarkers.

Methods and analysis
This is a prospective observational study at a single centre (Guy’s and St Thomas’ NHS Foundation Trust) to generate PDOs from patients’ samples to assess treatment response and to correlate with patients’ treatment outcomes. Patients will be included if they are diagnosed with HNSCC undergoing curative treatment (primary surgery or radiotherapy) or presenting with recurrent or metastatic cancers and they will be categorised into three groups (cohort 1: primary surgery, cohort 2: primary radiotherapy and cohort 3: recurrent/metastatic disease). Research tumour samples will be collected and processed into PDOs and chemosensitivity/radiosensitivity will be assessed using established methods. Moreover, blood and other biological samples (eg, saliva) will be collected at different time intervals during treatment and will be processed in the laboratory for plasma and peripheral blood mononuclear cell (PBMC) isolation. Plasma and saliva will be used for circulating tumour DNA analysis and PBMC will be stored for assessment of the peripheral immune characteristics of the patients as well as to perform co-culture experiments with PDOs. SOTO study (correlation of the treatment Sensitivity of patient-derived Organoids with Treatment Outcomes in patients with head and neck cancer) uses the collaboration of several specialties in head and neck cancer and has the potential to explore multiple areas of research with the aim of offering a valid and effective approach to personalised medicine for cancer patients.

Ethics and dissemination
This study was approved by North West-Greater Manchester South Research Ethics Committee (REC Ref: 22/NW/0023) on 21 March 2022. An informed consent will be obtained from all participants prior to inclusion in the study. Results will be disseminated via peer-reviewed publications and presentations at international conferences.

Trial registration number

NCT05400239
.
Endoscopic sphincterotomy to prevent post-ERCP pancreatitis after self-expandable metal stent placement for distal malignant biliary obstruction (SPHINX): a multicentre, randomised controlled trial
Authors: Onnekink Anke M , Gorris Myrte , Bekkali Noor LH , Bos Philip , Didden Paul , Dominguez-Muñoz J Enrique , Friederich Pieter , van Halsema Emo E , Hazen Wouter L , van Huijgevoort Nadine C , Inderson Akin , Jacobs Maarten AJM , Koornstra Jan J , Kuiken Sjoerd , Scheffer Bob CH , Sloterdijk Hilbert , van Soest Ellert J , Venneman Niels G , Voermans Rogier P , de Wijkerslooth Thomas R , Wonders Janneke , Zoutendijk Roeland , Zweers Serge JLB , Fockens Paul , Verdonk Robert C , van Wanrooij Roy L J , Van Hooft Jeanin E 
Published: October 2024

Background
Endoscopic retrograde cholangiopancreatography (ERCP) with fully covered self-expandable metal stent (FCSEMS) placement is the preferred approach for biliary drainage in patients with suspected distal malignant biliary obstruction (MBO). However, FCSEMS placement is associated with a high risk of post-ERCP pancreatitis (PEP). Endoscopic sphincterotomy prior to FCSEMS placement may reduce PEP risk.

Objective
To compare endoscopic sphincterotomy to no sphincterotomy prior to FCSEMS placement.

Design
This multicentre, randomised, superiority trial was conducted in 17 hospitals and included patients with suspected distal MBO. Patients were randomised during ERCP to receive either endoscopic sphincterotomy (sphincterotomy group) or no sphincterotomy (control group) prior to FCSEMS placement. The primary outcome was PEP within 30 days. Secondary outcomes included procedure-related complications and 30-day mortality. An interim analysis was performed after 50% of patients (n=259) had completed follow-up.

Results
Between May 2016 and June 2023, 297 patients were included in the intention-to-treat analysis, with 156 in the sphincterotomy group and 141 in the control group. After the interim analysis, the study was terminated prematurely due to futility. PEP did not differ between groups, occurring in 26 patients (17%) in the sphincterotomy group compared with 30 patients (21%) in the control group (relative risk 0.78, 95% CI 0.49 to 1.26, p=0.37). There were no significant differences in bleeding, perforation, cholangitis, cholecystitis or 30-day mortality.

Conclusion
This trial found that endoscopic sphincterotomy was not superior to no sphincterotomy in reducing PEP in patients with distal MBO. Therefore, there was insufficient evidence to recommend routine endoscopic sphincterotomy prior to FCEMS placement.

Trial registration number
NL5130.
Multicenter clinical trial evaluating the safety and efficacy of mechanical thrombectomy using the Versi Retriever
Authors: Ohara Nobuyuki , Imamura Hirotoshi , Satow Tetsu , Yamagami Hiroshi , Yoshimura Shinichi , Horie Nobutaka , Ishii Akira , Fujinaka Toshiyuki , Matsumoto Yasushi , Tsumoto Tomoyuki , Kohyama Shinya , Matsumaru Yuji , Iihara Koji , Kuwayama Naoya , Hirano Teruyuki , Ito Yasushi , Yamamoto Haruko , Nagai Yoji , Sakai Chiaki , Sakai Nobuyuki 
Published: October 2024

BackgroundThis study aimed to elucidate the safety and efficacy of mechanical thrombectomy using the Versi Retriever in patients with acute ischemic stroke (AIS).MethodsThis was a prospective, multicenter, single-arm study conducted at 10 institutes in Japan from December 2018 to March 2021 on mechanical thrombectomy using the Versi Retriever in patients with AIS. The primary efficacy outcome was the modified Rankin scale (mRS) 0–2 at 90 days after the procedure. The primary safety outcome was mortality within 90 days after the procedure.ResultsFifty-eight patients with a mean age of 72.7 years were enrolled in the study. The primary efficacy outcome of mRS 0–2 at 90 days was 62.0% (95% CI 47.2–75.3%) in patients within 8 hours of stroke onset. The rate of immediate reperfusion of Thrombolysis in Cerebral Infarction (TICI) grade 2b-3 using the Versi Retriever in three passes was 78.0% (64.0–88.5%). The rate of final reperfusion of TICI 2b-3 was 100% (92.9–100%). The primary safety outcome of mortality within 90 days was 8.0% (2.2–19.2%) in patients within 8 hours of AIS onset. The incidence of intracranial hemorrhage within 24 hours was 12.0% (4.5–24.3%) for symptomatic cases and 32.0% (19.5–46.7%) for asymptomatic cases.ConclusionThe Versi Retriever proved to be a safe and effective option for mechanical thrombectomy in patients with AIS.