bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioelectrical Impedance Analysis (BIA) detects body resistance increase in dogs undergoing blood donation
Authors: Nisini Noemi , Corda Andrea , Birettoni Francesco , Miglio Arianna , Antognoni Maria Teresa 
Published: September 2024

AbstractUsing raw parameters of bioelectrical impedance analysis (BIA) and derived Phase Angle (PhA) has emerged as an alternative to conventional predictive BIA for body fluid volumes and body composition estimation in human patients, offering an approach independent of predictive equations. Classic predictive equation-based BIA remains unsuitable for veterinary clinical practice due to the high morphological variability within the canine species. This study aimed to validate the feasibility of BIA in dogs and assess its utility in detecting changes in body fluid volumes, particularly in blood donation. Sixty healthy blood donor dogs and ten controls were longitudinally assessed using BIA raw parameters with a portable analyzer at a 50 kHz frequency. Measurements were performed before and after blood donation in donor dogs, whereas in controls, they were carried out at two time points, approximating the timing of a donation. Significant increases in raw bioelectrical parameters were observed after blood donation in the donor group, while differences were not statistically significant in controls. Hematocrit values did not significantly differ between the two time points in both groups. These findings suggest the feasibility of using BIA to detect changes in body fluid volumes in dogs undergoing blood donation, highlighting its potential application in veterinary medicine. Further research should explore the applicability of BIA in spontaneous pathological conditions involving fluid loss or retention and investigate the potential utility of PhA as a prognostic or monitoring tool in veterinary clinical practice. This study provides valuable insights into using BIA in canine medicine, paving the way for enhanced diagnostic and monitoring strategies in clinical practice.
Machine Learning-Based Multifaceted Analysis Framework for Comparing and Selecting Water Quality Indices
Authors: Simian Dana , Șerban Marin-Eusebiu , Bărbulescu Alina 
Published: September 2024

Abstract
Water quality is essential to the population’s well-being, water resources management, and environmental development strategies. In this article, we propose a framework based on machine learning (ML) techniques for enhancing the assessment of water quality based on water quality indices (WQIs). It consists of three algorithms that could serve as a foundation for automating the evaluation of any resource based on indices and can operate locally or globally. Local-level algorithms assist in selecting suitable WQIs tailored to specific water sources and quality requirements, while global-level algorithm evaluates WQI robustness across diverse water sources. We also provide a warning system to mitigate differences in water quality evaluation using WQIs and a valuable tool (based on the features’ importance) for selecting ML models that prioritize the water parameters’ significance. The framework’s design draws upon conclusions from a case study involving the forecast and comparison of two WQIs for the Brahmaputra River. Any other data series, WQIs, and water parameters can be employed.
The Influence of Gentrification on Adverse Birth Outcomes in California
Authors: Gao Xing , Mujahid Mahasin S. , Nuru-Jeter Amani M. , Morello-Frosch Rachel 
Published: September 2024

AbstractEvidence has documented the effects of place on perinatal outcomes, but less is known about the sociopolitical mechanisms, such as gentrification, that shape neighborhood context and produce spatialized inequities in adverse birth outcomes. Leveraging a diverse sample in California, we assessed the associations between gentrification and birth outcomes: preterm birth, small-for-gestational-age, and low birth weight. Gentrification was measured using the Freeman method and the Displacement and Gentrification Typology. Descriptive analysis assessed outcome prevalence and race and ethnicity distribution by exposure and participant characteristics. Overall and race and ethnicity-stratified mixed effects logistic models examined associations between gentrification and birth outcomes, sequentially adjusting for sociodemographic status and pregnancy factors, with a random intercept to account for clustering by census tract. In a sample of 5,116,131 births, outcome prevalence ranged from 1.0% for very preterm birth, 5.0% for low birth weight, 7.9% for preterm birth, and 9.4% for small-for-gestational-age. Adjusting for individual-level factors, gentrification was associated with increased odds of preterm birth (Freeman OR = 1.09, 95% CI 1.07–1.10; Displacement and Gentrification Typology OR = 1.11, 95% CI 1.09–1.13). While Displacement and Gentrification Typology–measured gentrification was consistently associated with greater odds of adverse outcomes, Freeman-measured gentrification was associated with slightly lower odds of small-for-gestational-age and low birth weight. Furthermore, gentrification was associated with birth outcome odds across multiple racial and ethnic groups, but the directions and magnitudes of the associations varied depending on the gentrification assessment methodology and the outcome assessed. Results demonstrate that gentrification plays a role in shaping adverse birth outcomes in California.
Showcasing the Variety of Biosocial and Evolutionary Approaches in Sociology: Introduction to the Special Issue
Authors: Schnettler Sebastian , Huinink Johannes 
Published: September 2024

AbstractThis introduction to the special issue explores the increasing integration of biosocial and evolutionary approaches within sociology, highlighting the diverse ways in which these perspectives are incorporated into sociological research. In the past, sociology had reservations against or even rejected biological and evolutionary explanations of human behavior and often viewed them with skepticism. However, recent developments have seen a resurgence of interest in these approaches, leading to the emergence of interdisciplinary subfields such as biosociology, evolutionary sociology, neurosociology, and sociogenomics. This introduction provides a historical overview of biological and evolutionary thinking with regard to human behavior and sociality, tracing its roots from Darwinian theory to its contemporary applications within sociology. We discuss the conceptual and methodological differences between these approaches and offer an overview of key contributions that illustrate their relevance to core sociological topics. The articles in this special issue—which we summarize in this introduction—exemplify the variety of work being done at the intersection of sociology and the bio- and evolutionary sciences, from theoretical explorations to empirical studies. By presenting this range of interdisciplinary research, we aim to invite a broader sociological audience to engage with these perspectives, contributing to the development of a more comprehensive understanding of human behavior that sheds the dualism between nature and nurture—long overcome outside of sociology—for a consolidated effort to examine how nature and nurture are intertwined in multiple and complex ways.
Performance assessment of Jatropha seed oil as lubricant during turning of AISI 1525 steel using Taguchi-grey relational analysis methodology
Authors: Kazeem Rasaq Adebayo , Jen Tien-Chien 
Published: September 2024

AbstractIn recent years, industries have chosen high-speed machining to increase efficiency without sacrificing product quality. High-speed machining raises the temperature in the cutting zone, which has a negative impact on the component’s dimensional accuracy, surface quality, and tool performance. To get the greatest outcomes regarding surface quality and tool performance, it is crucial to identify the ideal value for machining parameters and cutting circumstances. In this work, tungsten carbide inserts were used in turning operations on AISI 1525 steel, utilizing Taguchi orthogonal L9 arrays in various cooling conditions by altering the spindle speed, feed rate, and depth of cut. Cutting temperature and surface roughness were simultaneously optimized using Taguchi and grey relational analysis. The ideal parameter setting for multi-responses was discovered, and the findings demonstrated a boost in grey relational analysis. The influence of each process parameter on cutting temperature and surface roughness was also determined using analysis of variance.
Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres)
Authors: Mattiolo Paola , Bevere Michele , Mafficini Andrea , Verschuur Anna Vera D. , Calicchia Martina , Hackeng Wenzel M. , Simbolo Michele , Paiella Salvatore , Dreijerink Koen M. A. , Landoni Luca , Pedron Serena , Cingarlini Sara , Salvia Roberto , Milella Michele , Lawlor Rita T. , Valk Gerlof D. , Vriens Menno R. , Scarpa Aldo , Brosens Lodewijk A. , Luchini Claudio 
Published: September 2024

AbstractGlucagonomas are functioning pancreatic neuroendocrine tumors (PanNETs) responsible for glucagonoma syndrome. This study aims to shed light on the clinicopathological and molecular features of these neoplasms. Six patients with glucagonomas were identified. All neoplasms were investigated with immunohistochemistry for neuroendocrine markers (Synaptophysin, Chromogranin-A), ATRX, DAXX, ARX, and PDX1 transcription factors. Fluorescent in situ hybridization (FISH) for assessing alternative lengthening of telomeres (ALT), and next-generation sequencing (NGS) for molecular profiling were performed. All cases were large single masses (mean size of 8.2 cm), with necrolytic migratory erythema as the most common symptom (6/6 cases, 100%). All neoplasms were well-differentiated G1 tumors, except one case that was G2. The tumors consistently showed classic/conventional histomorphology, with solid-trabecular and nested architecture. Lymphatic and vascular invasion (6/6, 100%), perineural infiltration (4/6, 66.6%), and nodal metastasis (4/6, 66.6%) were frequently observed. Transcription factors expression showed strong ARX expression in all tumors, and PDX1 expression in 5/6 cases (83.3%), indicating co-occurring alpha- and beta-cell differentiation. NGS showed recurrent somatic MEN1 and ATRX/DAXX biallelic inactivation. Cases with ATRX or DAXX mutations also showed matched loss of ATRX or DAXX protein expression and ALT. One case harbored somatic MUTYH inactivation and showed a high tumor mutational burden (TMB, 41.0 mut/Mb). During follow-up, one patient died of the disease, and four patients developed distant metastasis. Pancreatic glucagonomas are distinct PanNETs with specific clinicopathological and molecular features, including histological aspects of biological aggressiveness, co-occurring alpha- and beta-cell differentiation, MEN1 and DAXX/ATRX mutations enrichment, and the possible presence of high-TMB as an actionable marker.
Regulator of nonsense transcripts 3B is a prognostic biomarker and associated with immune cell infiltration in lung squamous cell and hepatocellular carcinoma
Authors: Li Pengcheng , Zhou Mi , Gan Xiaoli , Yuan Chaoyi , Li Ganxun , Jin Guan-nan , Ding Ze-yang 
Published: September 2024

Abstract
Purpose
The characteristic of RENT3B in cancer remains ambiguous. We aimed to study the relationship between RENT3B and immune infiltration in liver hepatocellular carcinoma (LIHC) and lung squamous cell carcinoma (LUSC).

Patients and methods
We investigated the expression levels of RENT3B using ONCOMINE and TIMER databases, and assessed the interrelationship between RENT3B expression and survival using PrognoScan, GEPIA, and Kaplan–Meier plotter. Additionally, we examined the association between RENT3B and immune cells in the tumor microenvironment (TME), as well as markers of immune cells, using TIMER. Subsequently, we performed prognostic analysis based on the expression level of RENT3B within specific immune cell subgroups. Furthermore, we evaluated the promoter methylation profile of RENT3B between tumor and normal tissues in LIHC and LUSC using the DNMIVD database.

Results
RENT3B exhibited increased levels in both in LIHC and LUSC. High RENT3B expression was associated with unfavorable prognosis in LIHC, whereas it indicated a beneficial prognosis in LUSC. In LIHC, the expression of RENT3B positively correlated with immune infiltration levels of B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells. However, in LUSC, the expression of RENT3B showed a negative correlation with immune infiltration levels of B cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells. RENT3B exhibited positive correlations with 42 immune markers in LIHC, while it displayed negative associations with 10 immune markers in LUSC. Despite variations in immune cell enrichment and reduction subgroups, high RENT3B expression consistently indicated poor prognosis in LIHC, whereas it remained favorable in LUSC. Additionally, there were no significant differences observed in RENT3B promoter methylation between tumor and normal tissues in both LIHC and LUSC.

Conclusion
RENT3B can affect the overall tumor prognosis and is associated with immune infiltration, especially in LIHC and LUSC. Consequently, RENT3B can become a prognostic biomarker for LIHC and LUSC.
Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms
Authors: Martocchia Antonio , Stefanelli Manuela , Gallucci Maurizio , Noale Marianna , Maggi Stefania , Cassol Maurizio , Postacchini Demetrio , Proietti Antonella , Barbagallo Mario , Dominguez Ligia J. , Ferri Claudio , Desideri Giovambattista , Toussan Lavinia , Pastore Francesca , Falaschi Giulia M. , Paolisso Giuseppe , Falaschi Paolo ,   The AGICO Investigators, Eleuteri Stefano , Falaschi Giulia Maria , Oddo Maria Grazia , Giuli Cinzia , Macchiati Ilenia , Migale Monica , Sorvillo Francesca , Brunelli Roberto , Francavilla Monia , Santini Silvia , Marini Luciano , Santillo Elpidio , Fallavollita Luca , Rotunno Sara , Barbieri Michelangela , Angellotti Edith , Ludovici Valeria , Cheli Paola , Pinto Rita Del , Dominguez Ligia J , Bella Giovanna , Culotta Valentino 
Published: September 2024

Abstract
Background
The mechanisms at the basis of depression are still matter of debate, but several studies in the literature suggest common pathways with dementia (genetic predispositions, metabolic and inflammatory mechanisms, neuropathological changes) and other geriatric syndromes.

Aims
To evaluate the role of cortisol (as marker of the HPA, hypothalamus–pituitary–adrenal axis hyperactivity) in elderly subjects with depressive symptoms (by the means of the AGICO, AGIng and COrtisol, study), in relationship to the presence of the major geriatric syndromes.

Methods
The AGICO study enrolled patients from ten Geriatric Units in Italy. Every subject received a comprehensive geriatric assessment or CGA (including the Mini Mental State Examination or MMSE, Geriatric Depression Scale or GDS and Cornell Scale for Depression in Dementia or CSDD), the neurological examination (with a computed tomography scan or magnetic resonance imaging of the brain), the assessment of the metabolic syndrome (MetS), the evaluation of the cortisol activity by two consecutive urine collections (diurnal and nocturnal), a CGA-derived frailty index (FI) and a modified measure of allostatic load (AL).

Results
The MMSE scores were significantly and inversely related to the values of GDS (p < 0.001) and CSDD (p < 0.05), respectively. The patients with depressive symptoms (GDS/CSDD > 8) showed significantly increased disability, MetS, inflammation, FI and AL and significantly reduced MMSE and renal function.
The diurnal and nocturnal urinary cortisol levels in the patients with depressive symptoms (GDS/CSDD > 8) were higher with respects to controls (p < 0.05 for nocturnal difference).

Discussion
The AGICO study showed that the stress response is activated in the patients with depression.

Conclusion
The depression in elderly patient should be reconsidered as a systemic disease, with coexisting major geriatric syndromes (disability, dementia, frailty) and combined pathogenetic mechanisms (metabolic syndrome, impaired renal function, low-grade inflammation, and allostatic load). Cortisol confirmed its role as principal mediator of the aging process in both dementia and metabolic syndrome.
High-Entropy Electrode Materials: Synthesis, Properties and Outlook
Authors: Li Dongxiao , Liu Chang , Tao Shusheng , Cai Jieming , Zhong Biao , Li Jie , Deng Wentao , Hou Hongshuai , Zou Guoqiang , Ji Xiaobo 
Published: September 2024

AbstractHigh-entropy materials represent a new category of high-performance materials, first proposed in 2004 and extensively investigated by researchers over the past two decades. The definition of high-entropy materials has continuously evolved. In the last ten years, the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage, electrocatalysis, and related domains, accompanied by a rise in techniques for fabricating high-entropy electrode materials. Recently, the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation approaches. However, the current definition of high-entropy materials remains relatively vague, and the preparation method of high-entropy materials is based on the preparation method of single metal/low- or medium-entropy materials. It should be noted that not all methods applicable to single metal/low- or medium-entropy materials can be directly applied to high-entropy materials. In this review, the definition and development of high-entropy materials are briefly reviewed. Subsequently, the classification of high-entropy electrode materials is presented, followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis methods. Finally, an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided, along with a proposal for potential future development directions for high-entropy materials.
Insights from a 19-year field study: optimizing long-term nutrient supply strategies for enhanced crop productivity and nutritional security in rice–wheat systems
Authors: Meena Sunita K. , Dwivedi Brahma S. , Meena Mahesh C. , Datta Siba P. , Singh Vinod K. , Mishra Rajendra P. , Chakraborty Debashish , Singh Renu , Dey Abir , Hasanain Mohammad , Meena Vijay Singh 
Published: September 2024

AbstractWhat nutrient supply options can ensure maximum productivity and optimize the nutrient uptake of rice–wheat system (R-W system)? an experiment started in the year 1998 (19-year-old) to examine the impact of optimal nutrient supply (NS) strategies to maximize crop productivity and nutritional security in R-W system. To determine the best nutrient management strategies (BNMS), seven different NS methods were tested. These included (organic and mineral fertilizers), as well as combinations such as integrated plant nutrition system (IPNS), IPNS + B (berseem), and IPNS + C (cowpea), with the aim of enhancing the productivity and nutrient absorption of R-W system. Results showed that rice grain yield notably wide-ranging from 1.61 to 5.81 t ha−1 under different NS options and highest rice grain yield (mean of 19 years) was observed at IPNS + C (5.81 t ha−1), which was at par with IPNS (5.79 t ha−1), STCR (soil test crop response) (5.76 t ha−1) and IPNS + B (5.67 t ha−1) followed by 100% recommended dose fertilizer NPK (4.41 t ha−1), which equality with OF (organic farming) (4.04 t ha−1) and lowest was recorded in control plot (1.61 t ha−1). Wheat grain yield varied significantly from 1.43 to 5.86 t ha−1 under different NS options. The highest yield (mean of 19 years) was observed in treatments IPNS + B (5.86 t ha−1), IPNS (5.77 t ha−1), IPNS + C (5.48 t ha−1), and STCR (5.45 t ha−1), followed by OF at 4.49 t ha−1, NPK at 3.76 t ha−1, with the lowest in the control plot at 1.43 t ha−1. Additionally, total phosphorus and sulfur accumulation in rice (grain: 8.41 to 39.09 kg ha−1; straw: 6.02 to 23.54 kg ha−1) varied significantly across nutrient supply treatments. Overall, adoption of IPNS integration with legumes (IPNS + B and IPNS + C), can significantly improve productivity and nutrient accumulation in R-W systems. Incorporating legumes into farming practices is advised for sustained productivity and nutritional benefits.
The potential contribution of Canarium schweinfurthii Engl. fruit pulp in the management of type 2 diabetes mellitus
Authors: Tabula Arthur , Bamuwamye Michael , Nakyinsige Khadijah 
Published: September 2024

AbstractDiet is the main modifiable risk factor underlying the progression of Type 2 Diabetes mellitus (T2DM). The African olive (Canarium schweinfurthii Engl.) of the family Burseraceae and genus Canarium is a source of food and medicine. This review summarized information on the nutritional and chemical composition of the Canarium schweinfurthii Engl. fruit pulp and explored its potential application in the management of T2DM. The literature search covered scientific databases comprising of Science Direct, Springer, Multidisciplinary Digital Publishing Institute, Science Hub and Google Scholar, from April 2023 up to January 2024. The following keywords were used: “Canarium schweinfurthii Engl.”, “Canarium schweinfurthii Engl. fruit pulp”, “Canarium schweinfurthii Engl. nutrition value, chemical composition and bioactive compounds”, “Canarium schweinfurthii Engl. against T2DM”, and “Nutritional requirements for T2DM”. This review evaluates the current state of research of global literature from 1992 to 2022 (n = 450) on Canarium schweinfurthii Engl. and T2DM. Data and information from literature (n = 115) was included in the review. The results of different studies showed that Canarium schweinfurthii Engl. fruit was composed of a wide range of nutritional and chemical components such as minerals, amino acids, fatty acids and vitamins. In addition, the fruit contains bioactive compounds reported to be effective against T2DM. Canarium schweinfurthii Engl. contains phytochemicals such as saponins, phenolics, alkaloids and flavonoids that have positive effects on cardio-metabolic health. Although the T2DM therapeutic effects of Canarium schweinfurthii bark stem extracts and fruit pulp oil have been reported, the therapeutic potential of the whole fruit pulp is yet to be reported.
Graphical Abstract