bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einfluss des Verdübelungsgrades auf das Tragverhalten von Verbundträgern mit profilierten Betongurten
Authors: Eggert Florian , Kuhlmann Ulrike 
Published: July 2016

AbstractIm Rahmen eines europäischen Projekts wurden Verbundträger mit Obergurten aus Profilblechen mit Stahlbeton untersucht. Unter bestimmten Voraussetzungen führen die momentan gültigen Regeln in Eurocode 4 für den Mindestverdübelungsgrad dieser Träger zu einer unwirtschaftlichen Bemessung, besonders unter Verwendung moderner Trapezprofilbleche. Des Weiteren ist die Verdübelung durch den Sickenabstand der Profilbleche begrenzt. Um das realistische Verhalten von Verbundträgern mit niedrigem Verdübelungsgrad zu untersuchen, wurde eine umfassende Studie mit Versuchen an Push‐out‐Prüfkörpern sowie Biegeträgern durchgeführt. Die mit Hilfe dieser Versuche neu gewonnenen Erkenntnisse sollen zu neuen Regeln für die Mindestverdübelung und die Kopfbolzentragfähigkeit bei Anwendung mit Profilblechen führen.Influence of the degree of shear connection on the load‐bearing behaviour of composite beams with additional profiled steel decking. In the frame of a European research project, composite beams with additional profiled steel decking were investigated. Under certain conditions, current rules of Eurocode 4 lead to inefficient dimensions of composite beams especially in view of the minimum degree of shear connection, above all when using modern profiled steel decking. Furthermore, the connection of steel beam and concrete slab is limited by the rib distance of the steel decking profiles. To investigate the realistic behaviour of composite beams with low degrees of shear connection, a comprehensive study on push‐out specimens and short composite beams was carried out. New findings gained by these tests should lead to new rules for the minimum degree of shear connection and for the load‐bearing capacity of headed studs in combination with additional profiled steel decking.
Mathematik für Ingenieure und Naturwissenschaftler
Authors: Kurrer Karl‐Eugen 
Published: July 2016

AbstractPapula, L.: Mathematik für Ingenieure und Naturwissenschaftler. Band 1. Ein Lehr‐ und Arbeitsbuch für das Grundstudium.Papula, L.: Mathematik für Ingenieure und Naturwissenschaftler. Band 2. Ein Lehr‐ und Arbeitsbuch für das Grundstudium.Papula, L.: Mathematik für Ingenieure und Naturwissenschaftler. Band 3. Vektoranalysis, Wahrscheinlichkeitsrechnung, Mathematische Statistik, Fehler‐ und Ausgleichsrechnung.Papula, L.: Mathematik für Ingenieure und Naturwissenschaftler – Anwendungsbeispiele. 222 Aufgabenstellungen mit ausführlichen Lösungen.Papula, L.: Mathematische Formelsammlung. Für Ingenieure und Naturwissenschaftler.Papula, L.: Mathematik für Ingenieure und Naturwissenschaftler – Klausur und Übungsaufgaben.
Can risk factors, clinical history and symptoms be used to predict risk of ectopic pregnancy in women attending an early pregnancy assessment unit?
Authors: Ayim F. , Tapp S. , Guha S. , Ameye L. , Al-Memar M. , Sayasneh A. , Bottomley C. , Gould D. , Stalder C. , Timmerman D. , Bourne T. 
Published: July 2016

ABSTRACTObjectiveTo examine whether risk factors and symptoms may be used to predict the likelihood of ectopic pregnancy (EP) in women attending early pregnancy assessment units in the UK.MethodsThis was an observational cohort study of pregnant women under 12 weeks' gestation who were recruited from three London university hospitals between August 2012 and April 2013. One hospital continued recruitment between January and June 2015. A standardized information sheet incorporating patient demographics, medical history and symptoms was completed by patients and confirmed by examining clinicians. The outcome measure was final pregnancy location.ResultsThere were 1320 eligible patients included in the analysis, with a total of 72 EPs (rate of 6%). Pelvic pain and diarrhea > three times in the previous 24 h were independent symptoms that increased the risk of EP, with relative risks of 2.4 (95% CI, 1.4–4.0; P = 0.002) and 2.2 (95% CI, 1.08–4.5; P = 0.03), respectively. The only other independent marker of risk of EP was duration of vaginal bleeding; the risk of EP increased by 20% (95% CI, 14%–27%) for every 1‐day increment in duration (P < 0.001). A logistic regression model incorporating these factors demonstrated an area under the receiver–operating characteristics curve of 0.73 (95% CI, 0.67–0.79). The prevalence of EP was low when there was no pelvic pain, no diarrhea and the duration of bleeding was ≤ 3 days, with an EP rate of 2% (6/391). In the presence of a single risk factor, the EP rate increased to 5% (29/631) when only pelvic pain was present, 8% (1/12) when only diarrhea > three times in the previous 24 h was reported and 9% (9/103) when there was only vaginal bleeding with a duration > 3 days. Women with pelvic pain and vaginal bleeding of any severity for > 3 days had a high EP rate of 16% (23/146). In the nine women who also reported diarrhea > three times in the previous 24 h, two had EP.ConclusionsOnly the presence of pelvic pain, diarrhea > three times in the previous 24 h and duration of bleeding were symptoms that significantly increased the risk for EP in women attending early pregnancy assessment units. Risk factors and symptoms alone could not be used to predict reliably an EP. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Right ventricular outflow tract obstruction in complicated monochorionic twin pregnancy
Authors: Eschbach S. J. , Boons L. S. T. M. , Van Zwet E. , Middeldorp J. M. , Klumper F. J. C. M. , Lopriore E. , Teunissen A. K. K. , Rijlaarsdam M. E. , Oepkes D. , Ten Harkel A. D. J. , Haak M. C. 
Published: July 2016

ABSTRACTObjectivesSevere right ventricular outflow tract obstruction (RVOTO) is a potential complication in recipient twins of twin‐to‐twin transfusion syndrome (TTTS) that requires postnatal follow‐up or treatment. We aimed to evaluate pregnancy characteristics of neonates with RVOTO from complicated monochorionic twin pregnancies, determine the incidence of RVOTO in TTTS cases and construct a prediction model for its development.MethodsThis was an observational cohort study of all complicated monochorionic twin pregnancies with a postnatal diagnosis of RVOTO examined at our center. Cases were referred for evaluation of the need for fetal therapy or intervention because of TTTS, selective intrauterine growth restriction (sIUGR) or multiple congenital malformations in one of the twins. Ultrasound data were retrieved from our monochorionic twin database. Among liveborn TTTS recipients treated prenatally with laser therapy, those with RVOTO were compared with those without RVOTO (controls). We describe four additional cases with RVOTO that were not TTTS recipients.ResultsA total of 485 twin pregnancies received laser therapy for TTTS during the study period. RVOTO was diagnosed in 3% (11/368) of liveborn TTTS recipients, of whom two showed mild Ebstein's anomaly. Before laser therapy, pericardial effusion was seen in 45% (5/11) of RVOTO cases (P < 0.01) and abnormal A‐wave in the ductus venosus (DV) in 73% (8/11) (P = 0.03), significantly higher proportions than in controls. Mean gestational age at laser therapy was 17 + 3 weeks in RVOTO cases compared with 20 + 3 weeks in controls (P = 0.03). A prediction model for RVOTO was constructed incorporating these three significant variables. One TTTS donor had RVOTO after the development of transient hydrops following laser therapy. Three larger twins in pregnancies complicated by sIUGR developed RVOTO, the onset of which was detectable early in the second trimester.ConclusionsRVOTO occurs in TTTS recipient twins but can also develop in TTTS donors and larger twins of pregnancies complicated by sIUGR. Abnormal flow in the DV, pericardial effusion and early gestational age at onset of TTTS are predictors of RVOTO in TTTS recipients, which suggests increased vulnerability to hemodynamic imbalances in the fetal heart in early pregnancy. These findings could guide diagnostic follow‐up protocols after TTTS treatment. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Longitudinal follow‐up of levator ani muscle avulsion: does a second delivery affect it?
Authors: Chan S. S. C. , Cheung R. Y. K. , Lee L. L. , Choy R. K. W. , Chung T. K. H. 
Published: July 2016

ABSTRACTObjectivesTo evaluate the morphological outcome of levator ani muscle (LAM) avulsion 3–5 years after a first delivery and to assess the effect of a second delivery on this condition. The impact of LAM avulsion on pelvic floor disorders was also studied.MethodsSix hundred and sixty‐six women who had been assessed for LAM avulsion 8 weeks after their first delivery were invited for a follow‐up examination 3–5 years later. Women completed the Pelvic Floor Distress Inventory including the Urinary Distress Inventory (UDI) and Pelvic Organ Prolapse Distress Inventory (POPDI) questionnaires to explore symptoms of pelvic floor disorders, and the pelvic floor was examined using three‐dimensional translabial ultrasound and assessed using the pelvic organ prolapse quantification system.ResultsThree hundred and ninety‐nine women completed the study, of whom 151 were multiparous. Mean interval between first delivery and follow‐up was 42.3 ± 7.6 months. Among 69 women who had LAM avulsion 8 weeks after their first delivery, nine (13.0%) had no LAM avulsion at follow‐up. One (0.9%) woman had a new LAM avulsion after her second vaginal delivery. A greater proportion of women with LAM avulsion reported symptoms of stress urinary incontinence (SUI) (adjusted odds ratio, 2.09 (95% CI, 1.18–3.70); P = 0.01) and symptoms of prolapse than did women without avulsion; however, this difference did not reach statistical significance (P = 0.61). Women with LAM avulsion had higher UDI and POPDI scores than did women without avulsion (median UDI score, 17.7 (interquartile range (IQR), 5.0–32.4) vs 9.2 (IQR, 0.0–22.1); P = 0.045 and median POPDI score, 20.8 (IQR, 8.8–40.5) vs 10.7 (IQR, 0.0–32.8); P = 0.021).ConclusionsThe risk of developing new LAM avulsion after a second vaginal delivery is low (0.9%). Healing of LAM avulsion was observed in 13% of women who had at least one vaginal delivery. At 3–5 years after delivery, women with LAM avulsion reported symptoms of SUI more often than did those without, and had higher UDI and POPDI scores, implying more bothersome symptoms. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
Fetal laser ablation of feeding artery of cystic lung lesions with systemic arterial blood supply
Authors: Cruz‐Martinez R. , Martínez‐Rodríguez M. , Bermúdez‐Rojas M. , Magaña‐Abarca C. , Narvaez‐Dominguez V. , Rojas‐Macedo A. , Bautista‐García N. , Alcocer‐Alcocer M. 
Published: July 2016

ABSTRACTObjectiveTo assess the effectiveness of laser surgery in fetuses with a cystic lung lesion with systemic arterial blood supply (hybrid lung lesion) at risk of perinatal death.MethodsA cohort of five consecutive fetuses with a large hybrid lung lesion associated with hydrops and/or pleural effusion with severe lung compression was selected for percutaneous ultrasound‐guided fetal laser ablation of the feeding artery (FLAFA) before 32 weeks' gestation in a single tertiary national referral center in Queretaro, Mexico. The primary outcomes were survival and need for postnatal surgery.ResultsFLAFA was performed successfully in all cases at a median gestational age of 24.9 (range, 24.4–31.7) weeks. After fetal intervention, dimensions in both lungs increased and fluid effusions resolved in all cases. All cases were delivered liveborn at term at a median gestational age of 39.6 (range, 38.0–39.7) weeks, without respiratory morbidity or need for oxygen support, resulting in perinatal survival of 100%. During follow‐up, three (60%) cases showed progressive regression of the entire lung mass and did not require postnatal surgery, whereas in two (40%) cases a progressive decrease in size of the mass was observed but a cystic portion of the lung mass persisted and postnatal lobectomy was required.ConclusionIn fetuses with large hybrid lung lesions at risk of perinatal death, FLAFA is feasible and could improve survival and decrease the need for postnatal surgery. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
GPS interferometric reflectometry: applications to surface soil moisture, snow depth, and vegetation water content in the western United States
Authors: Larson Kristine M. 
Published: July 2016

GPS interferometric reflectometry is a new environmental sensing technique that can be used to measure near‐surface soil moisture, snow depth, and vegetation water content variations. The spatial scale of this technique, ~1000 m2, is intermediate to that of other in situ sensors (<1 m2) and satellites (>100 km2). Soil moisture and snow depth retrievals have accuracies of 0.04 m3/m3 and 0.04 m, respectively. These accuracies are sufficient for many hydrologic applications. Fortuitously, GPS interferometric reflectometry can be used with consumer‐grade off the shelf GPS instruments that are operated by the geodetic, geophysical, and surveying communities. This means that GPS data from thousands of sites are potentially available for environmental scientists seeking new in situ data for soil moisture, snow depth, and vegetation water content. The technique can be applied to data from existing archives or for new sites. Although the accuracy of the technique has only been evaluated for the GPS constellation, the technique can also be used for other navigation constellations such as GLONASS, Galileo, and Beidou. WIREs Water 2016, 3:775–787. doi: 10.1002/wat2.1167This article is categorized under:

Science of Water > Hydrological Processes
Science of Water > Methods
Expanding the molecular diversity and phenotypic spectrum of glycerol 3‐phosphate dehydrogenase 1 deficiency
Authors: Dionisi‐Vici Carlo , Shteyer Eyal , Niceta Marcello , Rizzo Cristiano , Pode‐Shakked Ben , Chillemi Giovanni , Bruselles Alessandro , Semeraro Michela , Barel Ortal , Eyal Eran , Kol Nitzan , Haberman Yael , Lahad Avishai , Diomedi‐Camassei Francesca , Marek‐Yagel Dina , Rechavi Gideon , Tartaglia Marco , Anikster Yair 
Published: July 2016

AbstractTransient infantile hypertriglyceridemia (HTGT1; OMIM #614480) is a rare autosomal recessive disorder, which manifests in early infancy with transient hypertriglyceridemia, hepatomegaly, elevated liver enzymes, persistent fatty liver and hepatic fibrosis. This rare clinical entity is caused by inactivating mutations in the GPD1 gene, which encodes the cytosolic isoform of glycerol‐3‐phosphate dehydrogenase. Here we report on four patients from three unrelated families of diverse ethnic origins, who presented with hepatomegaly, liver steatosis, hypertriglyceridemia, with or without fasting ketotic hypoglycemia. Whole exome sequencing revealed the affected individuals to harbor deleterious biallelic mutations in the GPD1 gene, including the previously undescribed c.806G > A (p.Arg269Gln) and c.640T > C (p.Cys214Arg) mutations. The clinical features in three of our patients showed several differences compared to the original reports. One subject presented with recurrent episodes of fasting hypoglycemia along with hepatomegaly, hypetriglyceridemia, and elevated liver enzymes; the second showed a severe liver disease, with intrahepatic cholestasis associated with kidney involvement; finally, the third presented persistent hypertriglyceridemia at the age of 30 years. These findings expand the current knowledge of this rare disorder, both with regard to the phenotype and molecular basis. The enlarged phenotypic spectrum of glycerol‐3‐phosphate dehydrogenase 1 deficiency can mimic other inborn errors of metabolism with liver involvement and should alert clinicians to recognize this entity by considering GPD1 mutations in appropriate clinical settings.
Phase I dose-finding study of monotherapy with atezolizumab, an engineered immunoglobulin monoclonal antibody targeting PD-L1, in Japanese patients with advanced solid tumors
Authors: Mizugaki Hidenori , Yamamoto Noboru , Murakami Haruyasu , Kenmotsu Hirotsugu , Fujiwara Yutaka , Ishida Yoshimasa , Kawakami Tomohisa , Takahashi Toshiaki 
Published: July 2016

SummaryBackground Atezolizumab is an engineered immunoglobulin monoclonal antibody that targets the programmed death-1/programmed death-ligand 1 pathway. Methods In this phase I dose-finding study, we assessed the safety, feasibility, pharmacokinetics (PK), and exploratory anti-tumor activity of atezolizumab monotherapy up to 20 mg/kg in Japanese patients with advanced solid tumors who had failed standard therapy or for whom there is no standard therapy. Results Six patients were enrolled and received intravenous atezolizumab every 3 weeks (q3w) at doses of 10 or 20 mg/kg. Tumor types were non-small cell lung cancer (n = 3), melanoma (n = 1), pancreatic cancer (n = 1), and thymic cancer (n = 1). No dose-limiting toxicities were observed. All adverse events (AEs) were grade 1 or 2 in severity. No discontinuations or deaths due to AEs were observed. As of the data cutoff, no partial responses were observed; however, stable disease was observed in all six patients. The maximum mean serum atezolizumab concentration was 220 μg/mL (SD ± 21.9), with 10-mg/kg dosing and 536 μg/mL (SD ± 49.4) with 20-mg/kg dosing. Three patients were still on treatment, and three of the six had achieved a progression-free survival of >12 months. Conclusions Atezolizumab was well tolerated in Japanese patients at doses up to 20 mg/kg q3w. The safety profile and Cycle 1 serum atezolizumab concentrations were similar to those previously observed in non-Japanese patients. These data support the participation of Japanese patients in ongoing pivotal global studies of atezolizumab.
Patient Recall, Interpretation, and Perspective of an Inconclusive Long QT Syndrome Genetic Test Result
Authors: Predham Sarah , Hathaway Julie , Hulait Gurdip , Arbour Laura , Lehman Anna 
Published: July 2016

AbstractPatients’ perceptions of inconclusive results have been previously investigated in cancer genetics. The differences in how patients recall and interpret an uninformative test result compared to a known pathogenic result can affect medical decisions post disclosure. However, there is little to no data available on patients’ interpretation and perception of uninformative genetic results in inherited heart disease. We report the results of a qualitative analysis of 16 telephone interviews with participants who received a negative or a variant of unknown significance (VUS) result from Long QT syndrome (LQTS) genetic testing. Our results suggest that the type of result (negative versus VUS) does not affect recall, regardless of the reason for testing. When receiving a negative result, a majority of participants appropriately perceived no change in their diagnosis, while the perception of risk for family members varied. The majority of participants felt they maintained an awareness of their condition after the result disclosure, and that clinical follow‐up was similar to that planned prior to the genetic test result. Further work is needed to determine if there are any differences between obtaining a VUS result versus a negative result in this population.
Fertility of patients with polycystic ovary syndrome undergoing in vitro fertilization by age
Authors: Hwang Yu‐Im , Cha Sun‐Wha , Song In‐Ok , Yang Kwang‐Moon , Min Eung‐Gi , Kim Hye‐Ok 
Published: July 2016

AbstractObjectiveTo evaluate outcomes of in vitro fertilization (IVF) among patients with polycystic ovary syndrome (PCOS) by age.MethodsIn a retrospective study, data were retrieved for patients with PCOS (Rotterdam 2003 criteria) and individuals with tubal factor infertility who underwent IVF at a center in Seoul, South Korea, between January 2003 and August 2012. IVF outcomes were compared by age group (A: 30–32 years; B: 33–35 years; C: 36–38 years; D: 39–41 years).ResultsThe analysis included 307 women with PCOS and 364 with tubal factor infertility. There was a significant difference between women with PCOS and those with tubal infertility factor in the live birth rate in group B (41.3% vs 28.6%, P = 0.038) and in group C (40.4% vs 15.1%, P = 0.002). Among women with PCOS, no significant differences in number of retrieved oocytes were observed between the age groups (18.8 ± 9.6, 19.1 ± 10.0, 17.7 ± 7.5, and 17.0 ± 13.8). However, the clinical pregnancy rate was significantly lower in group D than in group C (47.2% vs 18.8%, P = 0.042).ConclusionFertility in patients with PCOS was maintained until age 38 years using IVF. Thereafter, the pregnancy rate decreased, although the number of oocytes retrieved by IVF remained stable.
Sleep disorders in children with chronic kidney disease
Authors: Darwish Amira H. , Abdel-Nabi Hend 
Published: July 2016

Background and Objectives:
This case-control study assessed the prevalence of sleep disorders among Egyptian children with chronic kidney disease (CKD), either maintained or not maintained on hemodialysis (HD), and compared them with healthy age and sex-matched children.

Patients and methods:
The total study population included 95 children, 54 of whom were CKD patients, 22 maintained on HD and 32 not maintained on HD; 41 healthy children of matched age and sex composed the control group.
Subjective impairment of sleep quality was assessed using the Arabic version of the Children's Sleep Habits Questionnaire (CSHQ). Daytime sleepiness and restless leg syndrome (RLS) were assessed using a pediatric modification of the Epworth sleepiness scale (ESS) and RLS Questionnaire, respectively.

Results:
Sleep disturbances were detected in 75.9% of the studied children with CKD: 81.8% in children with CKD undergoing dialysis, and 71.8% in children with CKD not on dialysis. Excessive daytime sleepiness (EDS) and RLS symptoms were reported in 22% and 20.4% of the studied children with CKD, respectively.

Conclusions:
Sleep disturbances are very common among children with CKD. Sleep disturbances in patients with CKD include restless legs syndrome (RLS), excessive daytime sleepiness (EDS), sleep-disordered breathing (SDB), behavioral insomnias, and parasomnias.
Gravito-inertial waves in a differentially rotating spherical shell
Authors: Mirouh G. M. , Baruteau C. , Rieutord M. , Ballot J. 
Published: July 2016

The gravito-inertial waves propagating over a shellular baroclinic flow inside a rotating spherical shell are analysed using the Boussinesq approximation. The wave properties are examined by computing paths of characteristics in the non-dissipative limit, and by solving the full dissipative eigenvalue problem using a high-resolution spectral method. Gravito-inertial waves are found to obey a mixed-type second-order operator and to be often focused around short-period attractors of characteristics or trapped in a wedge formed by turning surfaces and boundaries. We also find eigenmodes that show a weak dependence with respect to viscosity and heat diffusion just like truly regular modes. Some axisymmetric modes are found unstable and likely destabilized by baroclinic instabilities. Similarly, some non-axisymmetric modes that meet a critical layer (or corotation resonance) can turn unstable at sufficiently low diffusivities. In all cases, the instability is driven by the differential rotation. For many modes of the spectrum, neat power laws are found for the dependence of the damping rates with diffusion coefficients, but the theoretical explanation for the exponent values remains elusive in general. The eigenvalue spectrum turns out to be very rich and complex, which lets us suppose an even richer and more complex spectrum for rotating stars or planets that own a differential rotation driven by baroclinicity.