bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular Interfacial Assembly: Integrating Supramolecular Hosts into Polymeric Membranes through an Aqueous Interface
Authors: Fang Fang , Liu Peiren , Lin Weibin , Alimi Lukman O. , Moosa Basem , Maltseva Elizaveta , Khashab Niveen M. 
Published: October 2024

AbstractEfficient incorporation of macrocycles in polymeric membranes can impart the overall matrix with new properties for a range of cutting‐edge applications. Here, we introduce a Supramolecular Interfacial Assembly (SIA) method for the fabrication of polymeric membranes featuring embedded macrocycles. Through harnessing the quasi‐liquid nature of the concentrated polymer solution, SIA orchestrates the homogeneous spreading of macrocycles in an aqueous layer on its surface, leading to the creation of an interface between “water/water” phases, subsequently forming a cross‐linked membrane driven by supramolecular electrostatic interactions. Remarkably, compared to the traditional interfacial polymerization, SIA adheres to a “green” paradigm without the need for organic solvents. The resultant composite membrane exhibits superior performance in organic solvent nanofiltration (OSN), owing to the precise molecular sieving property provided by the macrocycles with well‐defined permanent cavities. This fabrication method holds great promise for the innovative design and production of composite membranes that seamlessly integrates macrocycles with conventional polymers, which can greatly impact the design and preparation of advanced membrane materials in the future.
Electrospun Mesoporous Ni0.5Zn0.5Fe2O4 ‐ CNT ‐ Hollow Carbon Ternary Composite Nanofibers as High Performance Electrodes for Advanced Symmetric Supercapacitors
Authors: Sudheendra Budhiraju Venkata , Runkana Venkataramana , Sharma Ashutosh , Sivakumar Sri 
Published: October 2024

AbstractSpinel ferrites have attracted considerable interest in energy storage systems due to their unique magnetic, electrical and catalytic properties. However, they suffer from poor electronic conductivity and low specific capacity. We have addressed this limitation by synthesizing composite hollow carbon nanofibers (HCNF) embedded with nanostructured Nickel Zinc Ferrite (NZF) and Multiwalled carbon nanotubes (CNT), through coaxial electrospinning. These ternary composite nanofibers NZF‐CNT‐HCNF have a high specific capacity of 833 C g−1 at a current density of 1 A g−1 and have a capacity retention of 90 % after 3000 cycles. Their performance is much better than pure NZF fibers (180 C g−1) or hollow carbon nanofibers (96 C g−1), suggesting synergy between various constituents of the composite. A symmetric supercapacitor fabricated from NZF‐CNT‐HCNF composite nanofibers (30 % NZF) has a high specific capacity of 302 C g−1 (302 A g−1) at a current density of 1 A g−1 and has a capacity retention of 95 % after 5000 cycles. At the same current density, the device has a high energy density of 39 Whkg−1 and power density of 1000 Wkg−1 at a current density of 1 A g−1. This performance can be attributed to the high specific surface area (776 m2 g−1), mesoporosity (pore size ~4 nm), interconnectedness of the nanofibers and high electrical conductivity of CNTs. These fibers can be used as light‐weight high performance electrode materials in advanced energy storage devices.
Rapid Degradation of Dye Effluents with A SnS Catalyst: A Sustainable Approach Using Natural Light Under Ambient Conditions
Authors: Bhatia Geetanjali , Jagirdar Balaji R. 
Published: October 2024

AbstractDye degradation presents a persistent challenge in addressing water pollution. While several methods, including adsorption, biodegradation, and advanced oxidation processes, have been extensively explored, photocatalysis remains one of the most effective techniques. Conventional photocatalytic dye degradation processes often rely on expensive light sources and are time‐intensive. Herein, we synthesized a SnS catalyst by the solvated metal atom dispersion (SMAD) method, using Sn foil and sulfur powder. The catalyst exhibited remarkable performance, achieving complete degradation of methylene blue within 2 minutes under ambient room light, without the need for any external light source. Similar degradation efficiency was achieved for methyl orange. To evaluate the role of light for the degradation, control experiments were conducted in the dark using methylene blue as a model dye. Although the degradation rate was slightly reduced, the catalyst still facilitated dye degradation in the absence of light. Additionally, the catalytic performance was tested with four other dyes under natural light, all of which yielded promising results, demonstrating the versatility and effectiveness of the SnS catalyst in dye degradation. This work highlights the potential of the SnS catalyst for efficient and rapid dye degradation under both light and dark conditions, offering an energy‐efficient solution for wastewater treatment.
Are Recommendation Systems Annoying? An Empirical Study of Assessing the Impacts of AI Characteristics on Technology Well‐Being
Authors: Wang Zi , Yuan Ruizhi , Li Boying 
Published: October 2024

ABSTRACTRecommendation systems—that is, a class of machine learning algorithm tools that filter vendors' offerings based on customer data and automatically recommend or generate personalized predictions—are empowered by artificial intelligence (AI) technology and embedded with AI characteristics; but the potential consequences for customer well‐being are greatly overlooked. Hence, this research investigates the impact of AI characteristics on technology well‐being (self‐efficacy, technology satisfaction, emotional dissonance, and autonomy) through two mechanisms: intuitiveness versus intrusiveness. A literature review which conceptualizes AI characteristics and technology well‐being in the recommendation system context is followed by a US‐based survey approach which shows that higher levels of information optimization, predictability, human likeness, and customizability lead to higher levels of intuitiveness, whereas only information optimization and human likeness leads to increased intrusiveness. However, both intuitiveness and intrusiveness are found to promote technology well‐being in the context of a recommendation system, especially for those more vulnerable individuals who respond positively to intrusiveness. Hence, the conclusion is “the recommendations are not always annoying,” whereby the relationships between AI characteristics and technology well‐being are significantly influenced by perceived intrusiveness. These findings help business practitioners to identify how consumers perceive and engage different AI characteristics, and therefore could better take care of technology well‐being while boosting AI development.
Multidrug Resistance Reversed by Maleimide Interactions. A Biological and Synthetic Overview for an Emerging Field
Authors: Hernández‐Velázquez Edson D. , Granados‐López Angelica J. , López Jesús Adrián , Solorio‐Alvarado César R. 
Published: October 2024

AbstractMultidrug Resistance (MDR) can be considered one of the most frightening adaptation types in bacteria, fungi, protozoa, and eukaryotic cells. It allows the organisms to survive the attack of many drugs used in the daily basis. This forces the development of new and more complex, highly specific drugs to fight diseases. Given the high usage of medicaments, poor variation in active chemical cores, and self‐medication, the appearance of MDR is more frequent each time, and has been established as a serious medical and social problem. Over the years it has been possible the identification of several genes and proteins responsible for MDR and with that the development of blockers of them to reach MDR reversion and try to avoid a global problem. These mechanisms also have been observed in cancer cells, and several calcium channel blockers have been successful in MDR reversion, and the maleimide can be found included in them. In this review, we explore particularly the tree main proteins involved in cancer chemoresistance, MRP1 (encoded by ABCC1), BCRP (encoded by ABCG2) and P‐gp (encoded by ABCB1). The participation of P‐gp is remarkably important, and several aspects of its regulations are discussed. Additionally, we address the history, mechanisms, reversion efforts, and we specifically focused on the maleimide synthesis as MDR‐reversers in co‐administration, as well as on how their biological applications are imperative to expand the available information and explore a very plausible MDR reversion source.
The unlikely combination: Anderson–Fabry disease and congenital dyserythropoietic anemia type II in a pediatric patient
Authors: Elsherif Yasmine , Ibrahim Ismail A. , Elsherif Omar , Abukhadijah Hana J. 
Published: October 2024

Key Clinical MessageAnderson‐Fabry disease, a rare X‐linked lysosomal disorder, and congenital dyserythropoietic anemia (CDA) Type II, an autosomal recessive condition, both have distinct inheritance patterns. Their co‐occurrence is extremely rare, never been reported before. Therefore, screening is crucial for early management, and families should seek genetic counseling for children showing unusual presentations.AbstractAnderson‐Fabry disease (AFD) is a rare condition, characterized by a lysosomal storage disorder affecting lipid storage. It manifests in two forms: classic (early‐onset) and nonclassic (late‐onset). Conversely, congenital dyserythropoietic anemia (CDA) is a rare blood disorder caused by ineffective erythropoiesis, which results in the production of abnormal erythroblasts during the maturation of red blood cells, with CDA type II being the most frequent type. Both disorders have well‐understood pathophysiologies, yet they are genetically distinct. AFD is inherited in an X‐linked manner, whereas CDA type II follows an autosomal recessive pattern of inheritance. Although both AFD and CDA type II have been reported separately in the literature. The co‐existence for both AFD and CDA type II has not been reported. We describe a 10‐year‐old boy, with both which is believed to be the first documented case.
Exploring the Utility of Cell‐Penetrating Peptides as Vehicles for the Delivery of Distinct Antimalarial Drug Cargoes
Authors: Gare Caitlin L. , Palombi Isabella R. , White Andrew M. , Chavchich Marina , Edstein Michael D. , Lock Aaron , Avery Vicky M. , Craik David J. , McMorran Brendan J. , Lawrence Nicole , Malins Lara R. 
Published: October 2024

AbstractThe devastating impact of malaria includes significant mortality and illness worldwide. Increasing resistance of the causative parasite, Plasmodium, to existing antimalarial drugs underscores a need for additional compounds with distinct modes of action in the therapeutic development pipeline. Here we showcase peptide‐drug conjugates (PDCs) as an attractive compound class, in which therapeutic or lead antimalarials are chemically conjugated to cell‐penetrating peptides. This approach aims to enhance selective uptake into Plasmodium‐infected red blood cells and impart additional cytotoxic actions on the intraerythrocytic parasite, thereby enabling targeted drug delivery and dual modes of action. We describe the development of PDCs featuring four compounds with antimalarial activity—primaquine, artesunate, tafenoquine and methotrexate—conjugated to three cell‐penetrating peptide scaffolds with varied antiplasmodial activity, including active and inactive analogues of platelet factor 4 derived internalization peptide (PDIP), and a cyclic polyarginine peptide. Development of this diverse set of PDCs featured distinct and adaptable conjugation strategies, to produce conjugates with in vitro antiplasmodial activities ranging from low nanomolar to low micromolar potencies according to the drug cargo and bioactivity of the partner peptide. Overall, this study establishes a strategic and methodological framework for the further development of dual mode of action peptide‐drug antimalarial therapeutics.
Cocaine‐ and Amphetamine‐Regulated Transcript Peptide in the Central Nervous System of the Gecko, Hemidactylus leschenaultii: Molecular Characterization, Neuroanatomical Organization, and Regulation by Neuropeptide Y
Authors: Singh Omprakash , Basu Sumela , Srivastava Abhinav , Pradhan Dipti R. , Dandapat Pallabi , Bathrachalam Chandramohan , Singru Praful S. 
Published: October 2024

ABSTRACTNeuropeptide cocaine‐ and amphetamine‐regulated transcript (CART) is widely expressed in the brains of teleosts, amphibians, birds, and mammals and has emerged as a conserved regulator of energy balance across these vertebrate phyla. However, as yet, there is no information on CART in the reptilian brain. We characterized the cDNA encoding CART and mapped CART‐containing elements in the brain of gecko, Hemidactylus leschenaultii (hl) using a specific anti‐CART antiserum. We report a 683‐bp hlcart transcript containing a 336‐bp open reading frame, which encodes a putative 111‐amino acid hl‐preproCART. The 89‐amino acid hl‐proCART generated from hl‐preproCART produced two putative bioactive hl‐CART‐peptides. These bioactive CART‐peptides were > 93% similar with those in rats/humans. Although reverse transcription‐polymerase chain reaction (RT‐PCR) detected hlcart‐transcript in the brain, CART‐containing neurons/fibers were widely distributed in the telencephalon, diencephalon, mesencephalon, rhombencephalon, spinal cord, and retina. The mitral cells in olfactory bulb, neurons in the paraventricular, periventricular, arcuate (Arc), Edinger–Westphal, and brainstem nuclei were intensely CART‐positive. In view of antagonistic roles of neuropeptide Y (NPY) and CART in energy balance in the framework of mammalian hypothalamus, we probed CART–NPY interaction in the hypothalamus of H. leschenaultii. Double immunofluorescence showed a dense NPY‐innervation of Arc CART neurons. Ex vivo hypothalamic slices treated with NPY/NPY‐Y1‐receptor agonist significantly reduced hlcart‐mRNA levels in the Arc‐containing tissues and CART‐ir in the dorsal‐Arc. However, CART‐ir in ventral‐Arc was unaffected. NPY via Y1‐receptors may regulate energy balance by inhibiting dArc CART neurons. This study on CART in a reptilian brain fills the current void in literature and underscores the conserved feature of the neuropeptide across the entire vertebrate phyla.
Inter‐Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats
Authors: Veshchitskii Aleksandr , Shkorbatova Polina , Efimova Evgeniya , Merkulyeva Natalia 
Published: October 2024

ABSTRACTRat strains differ in physiology, behavior, and recovery after central nervous system injury. To assess these differences, we compared the gross and local anatomy and neuromorphology of the lumbar spinal cord of the Wistar and Dark Agouti (DA) strains. The key findings include (i) distinct spatial relationships between vertebrae and spinal segments in the two strains; (ii) Wistar rats have larger volumes of spinal cord gray and white matter; (iii) DA rats have smaller total neuronal populations, thus indicating an expectation of smaller local neuronal populations; (iv) this expectation was confirmed for interneurons expressing calbindin 28 kDa. But contrary to expectations, (v) DA rats had more numerous populations of the interneurons expressing parvalbumin and a population of α‐motoneurons. Consequently, these strains displayed divergent ratios in specific spinal neuronal populations. Researchers should consider these inter‐strain differences when comparing data across different strains.
Smooth asymptotics for collapsing Calabi–Yau metrics
Authors: Hein Hans‐Joachim , Tosatti Valentino 
Published: October 2024

AbstractWe prove that Calabi–Yau metrics on compact Calabi–Yau manifolds whose Kähler classes shrink the fibers of a holomorphic fibration have a priori estimates of all orders away from the singular fibers. To this end, we prove an asymptotic expansion of these metrics in terms of powers of the fiber diameter, with ‐order remainders that satisfy uniform ‐estimates with respect to a collapsing family of background metrics. The constants in these estimates are uniform not only in the sense that they are independent of the fiber diameter, but also in the sense that they only depend on the constant in the estimate for known from previous work of the second‐named author. For , the new estimates are proved by blowup and contradiction, and each additional term of the expansion arises as the obstruction to proving a uniform bound on one additional derivative of the remainder.
Crumb bums? Context dependence in ecosystem services supplied by common urban animals
Authors: Swartz Timothy M. , Blaney Alison R. , Behm Jocelyn E. 
Published: October 2024

AbstractBolstering the supply of animal‐mediated ecosystem services is an emerging priority in human‐altered landscapes. Such services are driven not only by environmental factors that shape communities of species that provide the service but also by the ecological context that affects the behavior of these species. In this study, we used a field experiment to investigate an ecosystem service that depends on resource use behavior—the removal of littered food waste by birds and squirrels in urban green spaces. We first explore how landscape‐scale urbanization affects the composition of the litter‐removing species community. We then examine two facets of waste removal provisioning—the amount of food removed and the speed of removal—and how they vary across ecological contexts represented by green space type (picnic areas, urban parks, and forest preserves), bird and squirrel abundance, number of people, amount of existing litter, and weather conditions. We found that although landscape‐scale urbanization affected the composition of species within green spaces, service provisioning was context‐dependent. Littered food removal services were provided at higher rates in park and picnic sites than in forest preserves and the abundance of eastern gray squirrels (Sciurus carolinensis) was a main driver of littered food removal services. Where squirrels were abundant, more food was removed, and food removal began and was completed more quickly. When squirrel abundance is accounted for, removal from picnic areas is higher than park sites, indicating context dependence in this service is likely driven by squirrel behavioral responses to ambient food waste levels in these habitats. This study highlights the role of common urban species in providing a valuable ecosystem service and the importance of ecological context in its supply. Efforts to account for animal‐mediated ecosystem services in human‐altered landscapes should address the potential for services to be driven by a single species and context‐dependent factors that influence behavior.
Using Environmental DNA to Detect and Identify Sweetpotato Whitefly Bemisia argentifolii and Twospotted Spider Mite Tetranychus urticae in Greenhouse‐Grown Tomato Plants
Authors: Lee‐Rodriguez Jonathan , Ranger Christopher M. , Leach Ashley , Michel Andrew , Reding Michael E. , Canas Luis 
Published: October 2024

ABSTRACTEnvironmental DNA (eDNA) consists of genetic material shed by living organisms, including those that are deceased, offering a unique opportunity to detect and identify terrestrial insect pests without requiring visual identification. The sweetpotato whitefly, Bemisia argentifolii, and the twospotted spider mite, Tetranychus urticae, are notorious for causing crop losses through virus transmission and direct feeding. Our study aimed to: (1) assess the effectiveness of B. argentifolii literature‐based PCR primers compared to newly developed primers for eDNA amplification, (2) evaluate the sensitivity of conventional PCR (cPCR) and real‐time quantitative PCR (qPCR) for detecting eDNA of B. argentifolii and T. urticae, (3) establish a rapid eDNA processing methodology using the LGC Biosearch Technologies QuickExtract DNA extraction kit and the Qiagen DNeasy Blood and Tissue kit, and (4) test the specificity of the developed primers against non‐target species. B. argentifolii and T. urticae were confined to tomato leaves (Solanum lycopersicum) using clip cages for 24 h, after which eDNA was collected from leaf surfaces using a water spray method, filtered, and processed for DNA amplification. While literature‐based primers showed sufficient sensitivity, their specificity for eDNA applications was inadequate, prompting the design of novel PCR primers for both pest species. Positive eDNA detection was achieved with both amplification methods, with qPCR proving more reliable than cPCR due to the latter's inconsistent performance with positive control samples. We also introduced a rapid eDNA processing approach using the QuickExtract DNA extraction kit, contrasting it with the more conventional Qiagen DNeasy Blood and Tissue kit. We believe that our findings are the first step toward the practical use of eDNA as a highly sensitive, early detection technique.
Baroreflex activation therapy in advanced heart failure: A long‐term follow‐up
Authors: Wang Dong , Mueller‐Leisse Johanna , Hillmann Henrike A.K. , Eiringhaus Jörg , Berliner Dominik , Karfoul Nizar , Schmitto Jan D. , Ruhparwar Arjang , Bauersachs Johann , Duncker David 
Published: October 2024

AbstractAimsBaroreceptor activation therapy (BAT) is a promising new treatment strategy for patients with heart failure with reduced ejection fraction (HFrEF). It provides symptomatic relief, improvement in left ventricular function and reduction of cardiac biomarkers. Data regarding the long‐term effect of BAT on HFrEF are scarce. This retrospective, monocentric study aimed to assess long‐term outcome in patients who underwent BAT.MethodsPatients with HFrEF who received BAT at Hannover Medical School between 2014 and 2023 were followed until the latest available follow‐up. Symptom burden, echocardiography and laboratory testing were assessed before BAT implantation and in subsequent follow‐ups.ResultsTwenty‐three patients (mean age 66 ± 10 years, 83% male) with HFrEF were included in the study. Aetiology of heart failure was ischaemic in 70%. The majority of patients (96%) suffered from New York Heart Association (NYHA) III with a mean left ventricular ejection fraction (LVEF) of 23 ± 8% and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) of 2463 ± 2922 pg/mL. A complication occurred in one patient during BAT implantation (4%). The mean follow‐up was 3 ± 2 (max. 7.5) years. BAT reduced NYHA classification in 12 patients (52%) after 1 year, of which one patient remained in ameliorated NYHA for 7.5 years. Echocardiographic evaluation revealed significant improvement in LVEF by 9 ± 9% after 1 year (P < 0.001) and by 11 ± 9% (P = 0.005) after 2 years. In addition, BAT mildly reduced NT‐proBNP in the first 2 years [non‐significantly after 1 year by 396 ± 1006 pg/mL and significantly after 2 years by 566 ± 651 pg/mL (P = 0.039)]. Seven patients reaching the recommended replacement time underwent device exchange. Four patients died during observation time.ConclusionsBAT resulted in a substantial reduction in NYHA classification and improvement in LVEF that lasted over long‐term follow‐up in many patients. NT‐proBNP level decreased interim in long‐term follow‐up. These findings highlight the long‐term efficacy and potential benefits of BAT as a therapeutic intervention for patients with HFrEF.