bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaussian Process Regression (GPR) Representation in Predictive Model Markup Language (PMML)
Authors: Park J. , Lechevalier D. , Ak R. , Ferguson M. , Law K. H. , Lee Y.-T. T. , Rachuri S. 
Published: April 2017

Abstract
This paper describes Gaussian process regression (GPR) models presented in predictive model markup language (PMML). PMML is an extensible-markup-language (XML) -based standard language used to represent data-mining and predictive analytic models, as well as pre- and post-processed data. The previous PMML version, PMML 4.2, did not provide capabilities for representing probabilistic (stochastic) machine-learning algorithms that are widely used for constructing predictive models taking the associated uncertainties into consideration. The newly released PMML version 4.3, which includes the GPR model, provides new features: confidence bounds and distribution for the predictive estimations. Both features are needed to establish the foundation for uncertainty quantification analysis. Among various probabilistic machine-learning algorithms, GPR has been widely used for approximating a target function because of its capability of representing complex input and output relationships without predefining a set of basis functions, and predicting a target output with uncertainty quantification. GPR is being employed to various manufacturing data-analytics applications, which necessitates representing this model in a standardized form for easy and rapid employment. In this paper, we present a GPR model and its representation in PMML. Furthermore, we demonstrate a prototype using a real data set in the manufacturing domain.
A Classification Scheme for Smart Manufacturing Systems’ Performance Metrics
Authors: Lee Y. T. , Kumaraguru S. , Jain S. , Robinson S. , Helu M. , Hatim Q. Y. , Rachuri S. , Dornfeld D. , Saldana C. J. , Kumara S. 
Published: April 2017

Abstract
This paper proposed a classification scheme for performance metrics for smart manufacturing systems. The discussion focused on three such metrics: agility, asset utilization, and sustainability. For each of these metrics, we discussed classification themes, which we then used to develop a generalized classification scheme. In addition to the themes, we discussed a conceptual model that may form the basis for the information necessary for performance evaluations. Finally, we present future challenges in developing robust, performance-measurement systems for real-time, data-intensive enterprises.
Cut in translation: ribosome‐dependent mRNA decay
Authors: Lalaouna David , Massé Eric 
Published: April 2017

Transcription and translation are two complex mechanisms that are tightly coupled in prokaryotic cells. Even before the completion of transcription, ribosomes attach to the nascent mRNA and initiate protein synthesis. Remarkably, recent publications have indicated an association between translation and decay of certain mRNAs. In this issue of The EMBO Journal, Leroy et al (2017) depicts a fascinating mechanism of mRNA degradation, which involves the ribosome‐associated ribonuclease Rae1 in Bacillus subtilis. In a translation‐dependent manner, Rae1 binds the ribosomal aminoacylation (A)‐site and cleaves between specific codons of the targeted mRNA.
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice
Authors: Tronchere Helene , Cinato Mathieu , Timotin Andrei , Guitou Laurie , Villedieu Camille , Thibault Helene , Baetz Delphine , Payrastre Bernard , Valet Philippe , Parini Angelo , Kunduzova Oksana , Boal Frederic 
Published: April 2017

AbstractPIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and mitochondrial integrity in chronic diet‐induced obesity. In vitro, we show that PIKfyve is critical for the control of mitochondrial fragmentation and hypertrophic and apoptotic responses to stress. We also provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial ROS production and apoptosis through a SIRT3‐dependent pathway in cardiomyoblasts. In addition, we report that chronic STA treatment improves cardiometabolic profile in a mouse model of cardiomyopathy linked to obesity. We provide evidence that PIKfyve inhibition reverses obesity‐induced cardiac mitochondrial damage and apoptosis by activating SIRT3. Furthermore, treatment of obese mice with STA improves left ventricular function and attenuates cardiac hypertrophy. In contrast, STA is not able to reduce isoproterenol‐induced cardiac hypertrophy in SIRT3.KO mice. Altogether, these results unravel a novel role for PIKfyve in obesity‐associated cardiomyopathy and provide a promising therapeutic strategy to combat cardiometabolic complications in obesity.
Clear: Composition of Likelihoods for Evolve and Resequence Experiments
Authors: Iranmehr Arya , Akbari Ali , Schlötterer Christian , Bafna Vineet 
Published: April 2017

Abstract
The advent of next generation sequencing technologies has made whole-genome and whole-population sampling possible, even for eukaryotes with large genomes. With this development, experimental evolution studies can be designed to observe molecular evolution “in action” via evolve-and-resequence (E&R) experiments. Among other applications, E&R studies can be used to locate the genes and variants responsible for genetic adaptation. Most existing literature on time-series data analysis often assumes large population size, accurate allele frequency estimates, or wide time spans. These assumptions do not hold in many E&R studies. In this article, we propose a method—composition of likelihoods for evolve-and-resequence experiments (Clear)—to identify signatures of selection in small population E&R experiments. Clear takes whole-genome sequences of pools of individuals as input, and properly addresses heterogeneous ascertainment bias resulting from uneven coverage. Clear also provides unbiased estimates of model parameters, including population size, selection strength, and dominance, while being computationally efficient. Extensive simulations show that Clear achieves higher power in detecting and localizing selection over a wide range of parameters, and is robust to variation of coverage. We applied the Clear statistic to multiple E&R experiments, including data from a study of adaptation of Drosophila melanogaster to alternating temperatures and a study of outcrossing yeast populations, and identified multiple regions under selection with genome-wide significance.
Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage inDrosophila melanogaster
Authors: Matsuoka Shinya , Armstrong Alissa R , Sampson Leesa L , Laws Kaitlin M , Drummond-Barbosa Daniela 
Published: April 2017

AbstractTwo papers in this issue demonstrate novel proteomic approaches that enhance genetic analysis. Matsuoka et al. investigated how diet-regulated........Nutrients affect adult stem cells through complex mechanisms involving multiple organs. Adipocytes are highly sensitive to diet and have key metabolic roles, and obesity increases the risk for many cancers. How diet-regulated adipocyte metabolic pathways influence normal stem cell lineages, however, remains unclear. Drosophila melanogaster has highly conserved adipocyte metabolism and a well-characterized female germline stem cell (GSC) lineage response to diet. Here, we conducted an isobaric tags for relative and absolute quantification (iTRAQ) proteomic analysis to identify diet-regulated adipocyte metabolic pathways that control the female GSC lineage. On a rich (relative to poor) diet, adipocyte Hexokinase-C and metabolic enzymes involved in pyruvate/acetyl-CoA production are upregulated, promoting a shift of glucose metabolism toward macromolecule biosynthesis. Adipocyte-specific knockdown shows that these enzymes support early GSC progeny survival. Further, enzymes catalyzing fatty acid oxidation and phosphatidylethanolamine synthesis in adipocytes promote GSC maintenance, whereas lipid and iron transport from adipocytes controls vitellogenesis and GSC number, respectively. These results show a functional relationship between specific metabolic pathways in adipocytes and distinct processes in the GSC lineage, suggesting the adipocyte metabolism–stem cell link as an important area of investigation in other stem cell systems.
Teachers’ evaluation of the project ”Little Physician” by the Polish Academy of Kids run at the Poznań University of Medical Sciences
Authors: Purandare Barbara , Korzeniowska Katarzyna Agnieszka , Stawczyk-Eder Kamila , Pawlaczyk Mariola 
Published: April 2017

Introduction. The project “Little Physician” has been run for over four years as a joint project of the Poznań University of Medical Sciences and the Polish Academy of Kids. It is an innovative undertaking in the international educational market, where young ‘scientists’ aged from 6 to 12 contribute to the classes and pursue their research interest in the broadly understood field of natural science. Aim. The aim of this research was to probe the opinions of the teachers participating in the “Little Physician” initiative. Material and Methods. The research was conducted on the population of 32 teachers. The applied technique was an interview based on an original questionnaire consisted of respondent`s particulars and 7 questions evaluating the usefulness, quality and thematic range of the classes, as well as the lecturers’ competencies and organisation of the classes. Results. The usefulness of the project was positively evaluated by all the interviewees (81% rated it as “very good”, 19% thought it was “good”). As many as 75% of the respondents decided that the thematic range of the lectures was “very good”. An even higher percentage assessed very positively the competencies of the adults giving lectures, the coordinators of the classes, the lecture halls and the manner in which classes were conducted. Conclusions. The project is very highly evaluated by the teachers supervising the participating children. The high assessment stems from the high competencies of the coordinators and lecturers participating in the classes, an accurate choice of issue or subjects discussed.
Toxicidade aguda da amônia em juvenis de sardinha-verdadeira Sardinella brasiliensis
Authors: BALOI Manecas Francisco , MAGNOTTI Caio César Franca , STERZELECKI Fábio Carneiro , RODRIGUES Ricardo Vieira , CERQUEIRA Vinicius Ronzani 
Published: April 2017

A sardinha-verdadeira (Sardinella brasiliensis) é o principal recurso pesqueiro do Brasil, sustentando diretamente a indústria de enlatados, como matéria prima, e indiretamente a pesca dos tuní­­deos, pois juvenis são utilizados como isca-viva. A UFSC, através do Projeto Isca-Viva, vem desenvolvendo técnicas de produção de sardinha-verdadeira em cativeiro com vistas ao uso sustentável do recurso, entretanto não existem informações sobre a toxicidade dos compostos nitrogenados no cultivo desta espécie. O objetivo deste estudo foi estimar a toxicidade aguda de amônia (NH3-N) em juvenis de sardinha-verdadeira. Grupos de cinco peixes (1,04 Â± 0,20 g) foram expostos a cinco concentrações de NH3-N (0,60 a 1,47 mg L-1) durante 96 h, mais um grupo controle em triplicata. Os testes foram conduzidos em um sistema semiestático com renovação diária total dos meios experimentais. Os resultados foram apresentados como dados de mortalidade, registrados nas diferentes concentrações testadas, utilizando o software Trimmed Spearman Karber Method. A concentração letal (LC50) após 96 h de exposição a NH3-N foi estimada em 0,74 (0,61-0,90) mg L-1. Os resultados indicam que juvenis de sardinha-verdadeira são relativamente sensí­­veis í­Â amônia em relação a outros peixes marinhos e que atenção especial deve ser dada a este composto em sistemas de cultivo.
Desempenho reprodutivo de lambaris alimentados com grãos secos de destilaria
Authors: ZIMBA Rosa Dulce , SUSSEL Fábio Rosa , OLIVEIRA Kátia Rodrigues Batista de , SEGURA Júlio Guerra , LIMA César Gonçalves de , VIEGAS Elisabete Maria Macedo 
Published: April 2017

Avaliou-se a influência dos ní­­veis de grãos secos de destilaria com solúveis (DDGS) no desempenho reprodutivo de lambaris. Foram elaboradas dietas contendo 0%, 10%, 20% e 30% de DDGS. Os peixes foram estocados durante 150 dias em 16 tanques com biofiltro, sistema individual de aquecimento e recirculação de água, na densidade de 0,3 peixe L-1. Foram determinados: fator de condição corporal, í­­ndice gonadossomático, volume dos ovos, fertilidade inicial, fertilidade inicial relativa, taxa de fertilidade, í­­ndice de desova, fertilidade final, fertilidade final relativa, taxa de eclosão e de sobrevivência das larvas, dií­¢metro dos ovos e do vitelo e comprimento das larvas. Realizaram-se também histologia das gônadas das fêmeas e dos machos e avaliação do sêmen. Os dados foram submetidos í­Â análise de varií­¢ncia, regressão e teste de tendência. A adição de DDGS nas dietas afetou a fertilidade inicial nas fêmeas, o peso, o comprimento total e o padrão dos machos (P<0,05). Para as outras variáveis não foram observadas diferenças (P>0,05). Não foram evidenciadas diferenças entre as estruturas morfológicas dos ovários, mas os testí­­culos dos peixes alimentados com dieta de 30% de DDGS apresentaram células espermáticas em abundí­¢ncia. O DDGS pode ser usado como alternativa proteica, sem gerar prejuí­­zos ao desempenho reprodutivo.
Análise histológica das brí­¢nquias e do fí­­gado de Bryconops caudomaculatus em diferentes concentrações de amônia
Authors: RIBEIRO Mayara da Cruz , MORON Sandro Estevan , LOPES Jane Mello 
Published: April 2017

O objetivo foi avaliar os efeitos de diferentes concentrações de amônia não ionizada (zero; 0,15; 0,30; 0,50; 1,00 mg L-1 NH3) na histologia e morfologia das brí­¢nquias e fí­­gado de juvenis de Bryconops caudomaculatus. Após 96 horas de exposição, os peixes foram anestesiados e submetidos í­Â necropsia para coleta de brí­¢nquias e fí­­gado, que foram incluí­­dos em parafina. Alterações morfológicas nas lamelas secundárias das brí­¢nquias foram observadas em concentrações a partir de 0,15 mg L-1, como hiperplasia, hipertrofia, deslocamento epitelial, fusão lamelar, edema, aneurisma lamelar com ruptura do epitélio e aumento na largura das lamelas. O fí­­gado apresentou alterações histológicas (congestão nos capilares, processos inflamatórios e pigmentação endógena) na presença de 0,30 mg L-1 de NH3, que comprometeram as funções vitais, o metabolismo, processos de respiração, desintoxicação do organismo, hematopoese e provavelmente a osmorregulação. Os resultados sugerem que as alterações nas brí­¢nquias e fí­­gado podem ser usadas para monitorar o desempenho de peixes em cultivo intensivo.
Escolha do hidrolisado de sardinha como atrativo alimentar pelo jundiá
Authors: VIEIRA Sara Fernanda Raithz Jordão , BERRI Alessandra Nelcir , MENEZES Camila Sousa Magela de , BESEN Kayane Pereira , PESSATTI Marcos Luis , FABREGAT Thiago El Hadi Perez 
Published: April 2017

O objetivo deste trabalho foi avaliar a eficiência do hidrolisado do resí­­duo de sardinha como atrativo alimentar para o jundiá (Rhamdia quelen), comparando sua escolha em relação í­Â de outros atrativos. Foram realizados dois experimentos: no primeiro, as substí­¢ncias foram inoculadas diretamente na água do aquário e, no segundo, incluí­­das em péletes de ágar. No experimento 1, a inoculação das substí­¢ncias (hidrolisado de sardinha, extrato de músculo de tilápia e água destilada) na água não afetou a distribuição dos peixes entre os compartimentos. No experimento 2, a maior proporção dos peixes entrou primeiro no compartimento contendo os atrativos (hidrolisado de sardinha, extrato de músculo de tilápia e ácido glutí­¢mico). Não foi encontrada diferença na distribuição dos peixes entre os compartimentos quando dois atrativos foram avaliados simultaneamente. Os péletes contendo extrato de músculo foram ingeridos primeiro e em maior quantidade em relação aos que continham água destilada. A avaliação dos atrativos em péletes mostrou que o hidrolisado de resí­­duo de sardinha é eficiente como atrativo alimentar para o jundiá. Não houve diferença na escolha em relação aos outros atrativos. A inclusão das substí­¢ncias em péletes é uma metodologia válida na avaliação de diferentes atrativos.
Women’s Individual Asset Ownership and Experience of Intimate Partner Violence: Evidence From 28 International Surveys
Authors: Peterman Amber , Pereira Audrey , Bleck Jennifer , Palermo Tia M. , Yount Kathryn M. 
Published: April 2017

Objectives. To assess the oft-perceived protective relationship between women’s asset ownership and experience of intimate partner violence (IPV) in the previous 12 months. Methods. We used international survey data from women aged 15 to 49 years from 28 Demographic and Health Surveys (2010–2014) to examine the association between owning assets and experience of recent IPV, matching on household wealth by using multivariate probit models. Matching methods helped to account for the higher probability that women in wealthier households also have a higher likelihood of owning assets. Results. Asset ownership of any type was negatively associated with IPV in 3 countries, positively associated in 5 countries, and had no significant relationship in 20 countries (P < .10). Disaggregation by asset type, sole or joint ownership, women’s age, and community level of women’s asset ownership similarly showed no conclusive patterns. Conclusions. Results suggest that the relationship between women’s asset ownership and IPV is highly context specific. Additional methodologies and data are needed to identify causality, and to understand how asset ownership differs from other types of women’s economic empowerment.
Towards Designing an Intercultural Curriculum: A Case Study from the Atlantic Coast of Nicaragua
Authors: Daniel Patricia 
Published: April 2017

One of the challenges still to be met in the 21st century is that of genuinely embracing diversity. How can education help to overcome the barriers that continue to exist between people on the basis of language, culture and gender? This case study takes the Atlantic Coast of Nicaragua as an example of a multilingual/multiethnic region and examines how the community university URACCAN is contributing to the development of interculturality. It describes participatory research that was carried out with university staff and students with the intention
of defining an intercultural curriculum and appropriate strategies for delivering such. One model used as a basis for discussions was the Model for Community Understanding from the Wales Curriculum Council, which emphasises the belonging of the individual to different communities or cultures at the same time. Factors supporting the development of an intercultural curriculum include the university’s close involvement with the ethnic communities it serves. However, ethno-linguistic power relations within the region and the country as a whole, still militate against egalitarianism within the university. The research highlights the importance of participatory pedagogy as the basis for promoting interculturality and achieving lasting social transformation.
The Difference the Body Makes: The Teacher’s Presence Online and Offline
Authors: Henriksson Carina 
Published: April 2017

This paper examines the question: what is the experience of meeting online and how does it differ from ordinary classroom situations? Drawing from personal experience, the author explores possible experiences of existing in virtual space and time. How do people meet, get to know each other and, interact in a pedagogical situation? Her experience as an online student made her to seriously reflect on the experiential nature of the computer-mediated encounter. But, it was not until she happened to participate in a workshop offered by the same teacher that the contrasts began to take shape for her. If there is a difference between online and offline meetings, what is it that makes the difference? Online communication could, just as face-to-face meetings, create feelings of closeness, and friendship; from the other-as-a-text on the screen, we subjectively create the other-as-an-idea, an idea that might be perceived as the real other. But is it? What reality is for real? What is the nature of the relationship established between
body-less persons on line, and what difference does the body make in a face-to-face meeting?
Promoting Teaching in Rural Schools
Authors: Ralph Edwin 
Published: April 2017

This study extends previous investigations of interns’ and their
cooperating teachers’ views of teaching in rural schools, which were conducted in 1998, 1999, 2000, and 2001. The present paper includes findings from a survey conducted in 2002 of a fifth cohort of interns and their classroom cooperating teachers. It examined the same four items analyzed in the four previous studies (namely: the advantages of teaching in rural areas, the disadvantages of doing so, recommendations about practicum placements for future interns, and advice for these interns), as well as items that also solicited respondents’ views of what
the University’s College of Education and the rural school divisions could do to promote both interning and teaching in rural schools. Findings are synthesized and implications are drawn for both the University and the school divisions involved in these studies as well as for other institutions in similar situations—with respect to improving internship and teaching, and to helping promote the stability of rural communities, of which the school is often a key component.
Academic Service Learning as Pedagogy: An Approach to Preparing Preservice Teachers for Urban Classrooms
Authors: Sulentic Dowell Margaret-Mary 
Published: April 2017

ABSTRACT

ACADEMIC SERVICE-LEARNING AS PEDAGOGY: AN APPROACH TO
PREPARING PRESERVICE TEACHERS FOR URBAN CLASSROOMS

Teacher education struggles with multifaceted and increasingly complex issues surrounding preparing majority (White) teachers to work effectively with minority (non-White) students, families and communities. Novice teachers entering the workforce need to be culturally responsive. What are the benefits to students, community, and university when academic service learning (AS-L) is a course component? How does AS-L impact the personal intellectual growth of preservice teachers?
This phenomenological qualitative study examined dispositions of 177 preservice teachers engaged in literacy and multicultural education courses with AS-L components. A nesting design was selected for this study situating preservice teachers in the center, surrounded by university teacher education coursework, which in turn, is surrounded by a larger circle encompassing local K-12 public schools and the community at large, where all are located.
Data were collected over the course of five consecutive semesters, using four different data sources, with written reflections the primary source. Ethnographic techniques of participant observation, informal and formal interviewing were also used to collect data. Artifacts and field notes resulting from observations and interview transcripts were considered when triangulating reflection data, comparing evidence from different sources and using multiple perceptions to clarify meaning. Using different data sources permitted examination of the same phenomena through different lens.
Data were analyzed using open coding, an inductive content analysis, and the constant comparative method, both systematic yet dynamic approaches. Comparing different data sources allowed for the comparison of views, situations, actions, and experiences of different individuals. Data analysis led to four significant categories: displacement, transformation, acceptance, and moving from negative, judgmental attitudes to positive, non-judgmental attitudes.
This investigation suggested that AS-L components improved and strengthened teacher education courses in terms of adequately preparing preservice teachers to teach successfully in urban environments. This study resulted in preservice teachers whose dispositions and appreciation of diversity and culturally responsive teaching increased.