bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cdc48 and Ubx1 participate in a pathway associated with the inner nuclear membrane that governs Asi1 degradation
Authors: Pantazopoulou Marina , Boban Mirta , Foisner Roland , Ljungdahl Per O. 
Published: August 2016

ABSTRACT
The nuclear envelope is a barrier comprising outer and inner membranes that separate the cytoplasm from the nucleoplasm. The two membranes have different physical characteristics and protein compositions. The processes governing the stability of inner nuclear membrane (INM) proteins are not well characterized. In Saccharomyces cerevisiae, the INM Asi1–Asi3 complex, principally composed of integral membrane proteins Asi1 and Asi3, is an E3 ubiquitin ligase. In addition to its well-documented function in endoplasmic reticulum (ER)-associated degradation, the Doa10 E3 ubiquitin ligase complex partially localizes to the INM. The Asi1–Asi3 and Doa10 complexes define independent INM-associated degradation (INMAD) pathways that target discrete sets of nuclear substrates for proteasomal degradation. Here, we report that Asi1 is rapidly turned over (t1/2≤30 min). Its turnover depends on ubiquitin-mediated degradation by nucleus-localized proteasomes, exhibiting a clear requirement for the E2 ubiquitin-conjugating enzyme Ubc7, Cue1 and the AAA ATPase Cdc48 and co-factor Ubx1. Asi1 turnover occurs largely independently of the Asi1–Asi3 or Doa10 complexes, indicating that it is subject to quality control at the INM in a manner distinct from that of the characterized INMAD pathways.
Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival
Authors: Diokmetzidou Antigoni , Soumaka Elisavet , Kloukina Ismini , Tsikitis Mary , Makridakis Manousos , Varela Aimilia , Davos Constantinos H. , Georgopoulos Spiros , Anesti Vasiliki , Vlahou Antonia , Capetanaki Yassemi 
Published: August 2016

ABSTRACT
The association of desmin with the α-crystallin Β-chain (αΒ-crystallin; encoded by CRYAB), and the fact that mutations in either one of them leads to heart failure in humans and mice, suggests a potential compensatory interplay between the two in cardioprotection. To address this hypothesis, we investigated the consequences of αΒ-crystallin overexpression in the desmin-deficient (Des−/−) mouse model, which possesses a combination of the pathologies found in most cardiomyopathies, with mitochondrial defects as a hallmark. We demonstrated that cardiac-specific αΒ-crystallin overexpression ameliorates all these defects and improves cardiac function to almost wild-type levels. Protection by αΒ-crystallin overexpression is linked to maintenance of proper mitochondrial protein levels, inhibition of abnormal mitochondrial permeability transition pore activation and maintenance of mitochondrial membrane potential (Δψm). Furthermore, we found that both desmin and αΒ-crystallin are localized at sarcoplasmic reticulum (SR)–mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 – the core component of mitochondrial contact site and cristae organizing system (MICOS) complex – and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.
Developing a policy to empower informal carers to administer subcutaneous medication in community palliative care; a feasibility project
Authors: Lee Louise , Howard Kay , Wilkinson Lyn , Kern Cheryl , Hall Sarah 
Published: August 2016

Background: This article describes the development and implementation of a policy to support community professionals to train informal carers to give, ‘as required ‘, subcutaneous medications to their relative. In a rural county, Lincolnshire, despite out of hours responsive services, patients could wait up to one hour for subcutaneous medications. Additionally there were increasing requests from carers to participate in this role. Aim: To provide a safe and effective framework via a robust policy to support informal carers to give, as required, subcutaneous medications in today's health-care environment. Methods: A group of professionals working in adult community palliative care formed a working party to scope the literature and existing policies, and to consider risks, legalities and local infrastructure. The policy was developed and based on available literature. A consultation process on the policy was commenced before a series of educational workshops supported its roll out. Results: The small number of informal carers (n=5) who undertook this role reported positive experiences and felt empowered. Professionals found the policy was able to be implemented quickly and was adhered to. Conclusion: From the small numbers audited it could be suggested that if the process is well managed and the informal carers feel supported they can safely and effectively administer subcutaneous injections in community palliative care. More importantly, if a policy is available, staff can respond to requests from carers in a timely manner.
Nurse-led palliative care services facilitate an interdisciplinary network of care
Authors: Imhof Lorenz , Kipfer Stephanie , Waldboth Veronika 
Published: August 2016

Background:Caring for palliative patients at home is complex and challenging. Specialist palliative care exists to provide high quality of care in complex situations. This study aimed to describe the characteristics of a specialist nurse-led palliative care service in an urban Swiss region.Methods:A qualitative study design adopting a grounded theory approach was used. Semi-structured interviews were conducted with 41 participants including family caregivers, home care nurses, referring services, treating physicians, specialist nurses and external politicians. In addition, statistical information was included.Findings:Specialist nurses played an important role in building and maintaining an interdisciplinary network of care, necessary for the management of complex palliative situations. They performed tasks such as to “include” members and to “negotiate” the network of care with the family and providers. They “tailored” the support to patients and families' needs and as a result “empowered” the network of care.Conclusion:A nurse-led palliative care service facilitated interdisciplinary palliative home care to the benefit of all agents involved.
Low-dose dexamethasone during arthroplasty
Authors: Wegener Jessica T. , Kraal Tim , Stevens Markus F. , Hollmann Markus W. , Kerkhoffs Gino M.M.J. , Haverkamp Daniël 
Published: August 2016

Dexamethasone is commonly applied during arthroplasty to control post-operative nausea and vomiting (PONV). However, conflicting views of orthopaedic surgeons and anaesthesiologists regarding the use of dexamethasone raise questions about risks of impaired wound healing and surgical site infections (SSI). The aim of this systematic review is to determine the level of evidence for the safety of a peri-operative single low dose of dexamethasone in hip and knee arthroplasty. We systematically reviewed literature in PubMed, EMBASE and Cochrane databases and cited references in articles found in the initial search from 1980 to 2013 based on predefined inclusion criteria. The review was completed with a ‘pro’ and ‘con’ discussion. After identifying 11 studies out of 104, only eight studies met the inclusion criteria. In total, 1335 patients were studied without any incidence of SSI. Causes of SSI are multifactorial. Therefore, 27 205 patients would be required (power = 90%, alpha = 0.05) to provide substantiated conclusions on safety of a single low dose of dexamethasone. Positively, many studies demonstrated showed convincing effects of low-dose dexamethasone on prevention of PONV and dose-dependent effects on post-operative pain and quality of recovery. Dexamethasone induces hyperglycaemia, but none of the studies demonstrated a concomitant SSI. Conversely, animal studies showed that high dose dexamethasone inhibits wound healing. A team approach of anaesthesiologists and orthopaedic surgeons is mandatory in order to balance the risk–benefit ratio of peri-operatively applied steroids for individual arthroplasty patients. We did not find evidence that a single low dose of dexamethasone contributes to SSI or wound healing impairment from the current studies. Cite this article: Wegener JT, Kraal T, Stevens MF, Hollman MW, Kerkhoffs GMMJ, Haverkamp D. Low-dose dexamethasone during arthroplasty: what do we know about the risks? EFORT Open Rev 2016;1:303-309. DOI: 10.1302/2058-5241.1.000039.
An Automated Method for Identifying Individuals with a Lung Nodule Can Be Feasibly
Implemented Across Health Systems
Authors: Farjah Farhood , Halgrim Scott , Buist Diana S.M. , Gould Michael K. , Zeliadt Steven B. , Loggers Elizabeth T. , Carrell David S. 
Published: August 2016

Introduction: The incidence of incidentally detected lung nodules is rapidly
rising, but little is known about their management or associated patient outcomes. One
barrier to studying lung nodule care is the inability to efficiently and reliably
identify the cohort of interest (i.e. cases). Investigators at Kaiser Permanente
Southern California (KPSC) recently developed an automated method to identify
individuals with an incidentally discovered lung nodule, but the feasibility of
implementing this method across other health systems is unknown.Methods: A random sample
of Group Health (GH) members who had a computed tomography in 2012 underwent chart
review to determine if a lung nodule was documented in the radiology report. A
previously developed natural language processing (NLP) algorithm was implemented at our
site using only knowledge of the key words, qualifiers, excluding terms, and the logic
linking these parameters.Results: Among 499 subjects, 156 (31%, 95% confidence interval
[CI] 27-36%) had an incidentally detected lung nodule. NLP identified 189 (38%, 95% CI
33-42%) individuals with a nodule. The accuracy of NLP at GH was similar to its accuracy
at KPSC: sensitivity 90% (95% CI 85-95%) and specificity 86% (95% CI 82-89%) versus
sensitivity 96% (95% CI 88-100%) and specificity 86% (95% CI
75-94%).Conclusion: Automated methods designed to identify individuals with an
incidentally detected lung nodule can feasibly and independently be implemented across
health systems. Use of these methods will likely facilitate the efficient conduct of
multi-site studies evaluating practice patterns and associated outcomes.
What Alert Thresholds Should Be Used to Identify Critical Risk Results: A Systematic Review of the Evidence
Authors: Campbell Craig A , Georgiou Andrew , Westbrook Johanna I , Horvath Andrea R 
Published: August 2016

AbstractBACKGROUNDPathology laboratories are required to immediately report results which indicate a patient is at critical risk, but there is little consensus about what values are deemed critical. The aim of this review was to systematically review the literature on alert thresholds for common chemistry and hematology tests in adults and to provide an explicit and ranked source of this evidence.METHODSThe literature search covered the period of 1995–2014. Evidence sources were critically appraised and ranked using the 1999 Stockholm hierarchy for analytical performance specifications in laboratory medicine modified for establishing decision limits.RESULTSThe 30 most frequently reported laboratory tests with alert thresholds are presented with evidence rankings. Similar thresholds were reported in North America, Europe and Asia. Seventy percent of papers reported thresholds set by individual institutions, while 18% contained thresholds from surveys of laboratories or clinicians. Forty-six percent of the papers referred to 1 or both of the 2 American laboratory surveys from the early 1990s. “Starter sets” of alert thresholds were recommended by 6 professional bodies, 3 of which were collaborations between pathologists and clinicians. None of the 9 outcome studies identified dealt with confounding factors.CONCLUSIONSRecommendations by professional bodies based on outdated surveys of the former state of the art or consensus are currently the best sources of evidence for laboratories to build their alert list. Well-designed outcome studies and greater collaboration between clinicians and the laboratory are needed to identify the most appropriate alert thresholds that signify actionable, critical or significant risk to patient well-being.
Folk music in a digital age: The importance of face-toface community values in filk music
Authors: Childs-Helton Sally 
Published: August 2016

Abstract
Filk is broadly defined as the traditional folk-based music and related community created by and for a sub-community of science fiction and fantasy fans. Born in the 1950s, filk today includes international participants of various experience levels and musical styles. Social context and music are equally important in this tradition; prominent values include self-expression, play and building a face-to-face co-creative, collaborative group experience. This article, founded on Textual Poachers (1992), assumes that filk remains a folk music in many ways, and that filkers still prefer face-to-face musical and personal interaction in spite of a lively, diverse online filk community. I gathered ethnographic data through participant-observation and a questionnaire to examine the following questions. How does the filk community value face-to-face and online interaction, how do filkers negotiate moving between these two domains and how do the domains interact? With four generations of filkers now active, are there generational differences? I postulate that the face-to-face group creativity and co-creation in filk is based on a fluid and permeable performer/audience boundary, allowing individual and group expression to happen simultaneously. This in-person, real-time, deeply immersive co-created experience reinforces a strong sense of community, making face-to-face interaction highly valued.
Fandom’s new frontier: Star Trek in the concert hall
Authors: Mccorkle Brooke 
Published: August 2016

Abstract
Star Trek’s fan group stands out as one of the oldest and most prominent within ‘nerd culture’, in both popular media and fan studies scholarship. The franchise has a long history of fan participation via fanzines, fan fiction, cosplay and conventions. Fan participation and consumption of Trek-related music has an equally extensive history. This article examines new ways in which music and Star Trek fandom intersect by focusing on the concert movies Star Trek: The Ultimate Voyage and Star Trek Movie Live. In these events, live musicians, typically an orchestra, performed a score in synchronization with projected visuals from a pre-existing movie or television show. The comparison of the events’ different approaches to format and marketing inform different means of fan musical engagement with Star Trek. Star Trek: The Ultimate Voyage attracted older ‘hard core’ fans by harnessing nostalgia in service of the production. Alternatively, Star Trek Movie Live opened up the doors of fandom to include not only Trekkers, but also other fandom subcultures and the general public. Ultimately, both events represent opportunities for the expansion of the classical music repertoire and the broadening of audiences.
‘Reading and [w]rocking’: Morality and musical creativity in the Harry Potter fandom
Authors: Hall Catherine 
Published: August 2016

Abstract
Wizard rock, often stylized in written form as ‘wrock’, creatively engages with and augments the content world of Harry Potter through musically and lyrically diverse performances. Fan studies centred on Harry Potter have often discussed the application of fictional heroism to real-world issues, and wizard rock musicians are frequently cited as fandom activists. However, there is little analysis of the music, lyrics and performances of wizard rock as it relates to the moral messages of the series. Focusing on the work of the first wizard rock band, Harry and the Potters, I unite ethnographic fieldwork with historical research and the study of myth to place wizard rock within a narrative of musical activism, fan creativity and morality in music. Similar to their heroes in the books, these musicians imbue their music and their self images with the series’ morals, historical tropes and archetypes. They make this morality tangible by donating proceeds of compilation albums or music subscription series sales to nonprofit organizations, and by weaving these messages into their music. I argue that the wizard rock community’s application of fictional heroism through music, lyrics and performance encourages fellow Harry Potter fans to embrace heroic qualities in the real world.
Recut and re-tuned: Fan-produced parody trailers
Authors: Deaville James 
Published: August 2016

Abstract
The term ‘recut’ designates a trailer that a fan has created by editing footage from a film or trailer to new sound (voice-over, sound effects and underscore). The resulting re-imagined audio-visual text typically presents a genre-shifted narrative that intertextually relates to the source material. The ‘re-tuning’ by fan-editors involves imposing a new soundtrack (usually music and/or narration) over reordered and edited images, like the adapted family-friendly ‘Shining’ (2005) from the horror film The Shining (Kubrick, 1980) or the horror trailer refashioning of ‘Mrs. Doubtfire – Recut’ (2009). The literature about ‘vidding’ and recutting provides a foundation for considering how fans provoke new meanings when they add or re-order voice-overs, sound effects and music in recut trailers. The fan-editor must creatively engage with genre-based cinematic trailer practices and traditions of musical signification in re-imagining the source text. Thus sound effects and electronically distorted music predominate in re-tuned horror trailers, like ‘Mrs. Doubtfire – Recut’ or ‘Scary Mary Poppins’ (2006), while light-hearted melodies and instrumentation prevail when adapting source material to create a recut comedy trailer (‘The Wicker Man’ 2006). Thus the recut and re-tuned trailer represents a transformative nexus of sight and sound within fandom.
Determinants of Business Fixed Investment: Evidence from German Firm-Level Data
Authors: Buettner Thiess , Hoenig Anja 
Published: August 2016

Abstract
This paper employs a novel firm-level dataset that combines financial accounts of German firms with data from a business survey to shed new light on the demand for capital. The empirical analysis employs firm-specific indicators in order to explore the effects of sales, the cost of capital and indicators of the business climate, which are used by the ifo Institute to provide a leading indicator for the German economy. The empirical results support a robust significant effect of a firm’s cost of capital on the stock of capital with an elasticity not significantly different from –1. Controlling for sales, a good rather than normal business situation is found to be associated with about 8 % higher investment.
20 Gbps Bidirectional Transmission via Four Channels over Long-haul SMF in a WDM-PON Architecture using External Modulation Scheme
Authors: Das Anindya Sundar , Patra Ardhendu Sekhar 
Published: August 2016

Abstract
A novel architecture of bidirectional gigabit signal transport system over long-haul single-mode fiber (SMF) using wavelength division multiplexed passive optical network technique is proposed and demonstrated. In order to offer multimedia services of high bandwidth, four signals of 5 Gbps data rates are externally modulated and transmitted through four channels over 100-km SMF in uplink and downlink. In our proposed scheme, an excellent bit error rate, good Q-factor and clear eye diagrams are observed for both 100-km uplink and downlink transmission. This architecture has potential to transmit 4×5 Gbps over long-haul fiber backbone and it will be useful in future broadband communications.
High-speed and Long-reach Hybrid AMI–WDM–PI Inter-satellite Communication System
Authors: Shatnawi Abdallah Ahmad , Bin Mohd Warip Mohd Nazri 
Published: August 2016

AbstractIn the current context of high-altitude platform communication system, inter-satellite communication is remarkable and highly effective. The present work aims to develop an integrated data transmission system incorporating alternate mark inversion, wavelength-division multiplexing, and polarization interleaving scheme for transmitting data of eight channels, each carrying 20 Gbps data over inter-satellite link of 5,000 km. The performance of the integrated data transmission of 160 Gbps data up to 5,000 km will be evaluated by means of signal-to-noise ratio, total received power, and eye diagram.
Forty years of language contact and change in Kupwar: A critical assessment of the intertranslatability model
Authors: Kulkarni-Joshi Sonal 
Published: August 2016

AbstractThis paper revisits the language contact situation in the Indian border town-village of Kupwar originally reported by Gumperz and Wilson (1971. Convergence and creolization: A case from the Indo-Aryan/Dravidian border. In D. Hymes (ed.),Pidgnization and creolization of languages, 151–168. Cambridge: CUP). The study presents evidence for morpho-syntactic variation and complexification in the contact varieties of the local languages, Marathi and Kannada. Similar patterns of variation are adduced from contact varieties of Marathi and Kannada from historical data as well as present-day border villages which, like Kupwar, have been traditionally bilingual. The synchronic and historical data point out methodological and theoretical limitations of the original study. The variation and complexity observed in the Kupwar varieties allow for a reconsideration of the notion of intertranslatability or isomorphism in convergence areas. While suggesting a possible geographically defined micro-linguistic area at the Marathi-Kannada frontier, the paper indicates that the recent re-drawing of state boundaries along linguistic lines may have initiated divergence in this convergence area.
Responsive methodology: Perspectives on data gathering and language documentation in India
Authors: Chelliah Shobhana L. 
Published: August 2016

AbstractLinguists continue a longstanding debate about the best methods for data gathering for language description and documentation. Under discussion is whether data gathered through elicitation of targeted structures through translations from a contact language or elicitation of grammaticality judgments gathers data to accurately represent the structure of language or if it is necessary to integrate these elicitation methods with the analysis of naturalistic speech to produce reliable and reproducible data sets. Given that language data is central to the development of language science and that language science feeds into studies of human cognition and behavior, the stakes are high that we get our data right and that means we need to get our methods right. Based on fieldwork and analysis that I conducted on Meitei, a Tibeto-Burman language of Northeast India, I compare results from gathering information using targeted elicitation and data gathering that integrates hypothesis-driven text-based and topic-based elicitation. I will show how mini-elicitation schedules can be derived during text analysis and how such schedules provide clearer clues to language structure than elicitation based on pre-constructed questionnaires based on a non-language specific understanding of language universals.
Context! Or how to read thoughts in a foreign language
Authors: Zeisler Bettina 
Published: August 2016

AbstractBased on personal experience during long term fieldwork in Ladakh, this article will discuss a special technique for field research. It will emphasise the need to access the speakers’ creative unconsciousness by applying the time-consuming ‘ping-pong game’, that is, by confronting every speaker with real language data, by rechecking each speaker’s statement with at least one other speaker, and by feeding back evaluations from a second or third speaker to an original speaker and back in an almost endless repetition. A special focus here will be on the collection of compounds showing the phenomenon of consonant migration and on data gathering with respect to verb semantics and verb valency.