bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: One‐Pot Synthesis of New Triazole—Imidazo[2,1‐b][1,3,4]thiadiazole Hybrids via Click Chemistry and Evaluation of Their Antitubercular Activity.
Authors: Ramprasad Jurupula , Nayak Nagabhushana , Dalimba Udayakumar , Yogeeswari Perumal , Sriram Dharmarajan 
Published: January 2016

AbstractTitle compounds (III) are synthesized via one‐pot click chemistry protocol.
ChemInform Abstract: Single‐Flask Multicomponent Palladium‐Catalyzed α,γ‐Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds.
Authors: Grigalunas Michael , Norrby Per‐Ola , Wiest Olaf , Helquist Paul 
Published: January 2016

AbstractA novel Pd‐catalyzed reaction sequence consisting of α‐alkenylation of a ketone with an alkenyl bromide and direct one‐pot coupling with an alkyl or alkenyl bromide is described providing access to structurally diverse α,β‐unsaturated ketones.
ChemInform Abstract: Reusable Biomacromolecule‐Pd Complex Catalyzed C—C Cross‐Coupling Reactions via C—S Cleavage of Disulfides.
Authors: Yang Quanlu , Wu Shang , Quan Zhengjun , Du Baoxin , Wang Mingming , Li Peidong , Zhang Yinpan , Lei Ziqiang , Wang Xicun 
Published: January 2016

AbstractNatural wool supported Pd(OAc)2‐complex is found to be an effective catalyst for the C—S bonds cleavage and C—C bonds formation from various disulfides with arylboronic acids or terminal alkynes, giving the desired coupling products in high yields.
ChemInform Abstract: Direct Synthesis of Hemiaminal Ethers via a Three‐Component Reaction of Aldehydes, Amines and Alcohols.
Authors: Beltran Alvaro , Alvarez Eleuterio , Diaz‐Requejo M. Mar , Perez Pedro J. 
Published: January 2016

Abstractin the presence of molecular sieves as a solid acid and dehydrating agent
ChemInform Abstract: Diastereoselective Fluorocyclopropanation of Chiral Allylic Alcohols Using an α‐Fluoroiodomethylzinc Carbenoid.
Authors: Navuluri Chandrasekhar , Charette Andre B. 
Published: January 2016

AbstractA highly diastereoselective fluorocyclopropanation of allylic alcohols (I), (IV), and (VI) and glyceraldehyde derived allylic ethers (VIII) and (X) is developed using fluorocarbenoid (II) as methylene source.
ChemInform Abstract: Ring Opening of Bicyclo[3.1.0]hexan‐2‐ones: A Versatile Synthetic Platform for the Construction of Substituted Benzoates.
Authors: Feierfeil Johannes , Grossmann Adriana , Magauer Thomas 
Published: January 2016

AbstractA convenient method is described for the thermolytic conversion of a range of structurally diverse bicyclo[3.1.0]hexan‐2‐ones having an ester and a chloro substituent on the three‐membered ring.
ChemInform Abstract: Ni(II)‐Catalyzed Sulfonylation of ortho C—H Bonds in Aromatic Amides Utilizing an N,N‐Bidentate Directing Group.
Authors: Yokota Ayana , Chatani Naoto 
Published: January 2016

AbstractThe Ni(II)‐catalyzed sulfonylation of ortho C—H bonds in aromatic amides of type (I) or (IV) is described.
ChemInform Abstract: Transition Metal‐Free Aroylation of NH‐Sulfoximines with Methyl Arenes.
Authors: Zou Ya , Xiao Jing , Peng Zhihong , Dong Wanrong , An Delie 
Published: January 2016

AbstractA simple procedure is elaborated for the synthesis of N‐aroyl sulfoximines (III) and (V) by an aroylation reaction of NH‐sulfoximines with methylarenes.
ChemInform Abstract: Water‐Soluble Salen—Pd Complex as an Efficient Catalyst for Suzuki—Miyaura Reaction of Sterically Hindered Substrates in Pure Water.
Authors: Liu Ya‐shuai , Gu Ning‐ning , Liu Ping , Ma Xiao‐wei , Liu Yan , Xie Jian‐wei , Dai Bin 
Published: January 2016

AbstractA wide range of biaryl compounds are obtained with high functional group tolerance.
ChemInform Abstract: On the Reactivity of Pyrido[3′,2′:4,5]furo(thieno)[3,2‐d]pyrimidin‐7(8)‐ones with Some Alkyl Mono‐ and Di‐halides: Synthesis of New Heterocyclic Systems Containing Thiazolo[3,2‐a]pyrimidine and Pyrimido[2,1‐b]thiazine Moiety.
Authors: Sirakanyan Samvel N. , Spinelli Domenico , Geronikaki Athina , Hovakimyan Anush A. 
Published: January 2016

AbstractThe reaction of the title compounds with methyl iodide gives S‐methylated compounds [e.g. (III)].
ChemInform Abstract: Synthesis of Novel Spiro[indol‐2,2′‐pyrroles] Using Isocyanide‐Based Multicomponent Reaction.
Authors: Jalli Venkataprasad , Krishnamurthy Suvratha , Kawasaki Hiroyoshi , Moriguchi Tetsuji , Tsuge Akihiko 
Published: January 2016

AbstractAn efficient and facile method for the synthesis of novel spiro[indole‐2,2′‐pyrroles] (IV) from N‐methyl‐3‐isatin imines, alkyl isocyanide, and dialkyl acetylenedicarboxylate is achieved by [3 + 2] cycloaddition reaction.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Spiropyrrolizidines and Piperazines Through Azomethine Ylide Cycloaddition Reaction.
Authors: Haddad Saoussen , Boudriga Sarra , Porzio Francois , Soldera Armand , Askri Moheddine , Knorr Michael , Rousselin Yoann , Kubicki Marek M. , Golz Christopher , Strohmann Carsten 
Published: January 2016

AbstractA new family of spirooxindolepyrrolizidines is obtained by an unprecedented isomerization of some spiroadducts obtained by one‐pot three‐component [3+2] cycloaddition reaction of pyrrolidinediones, L‐proline, and cyclic ketones.
ChemInform Abstract: Gold‐Catalyzed Cycloisomerization of [3]‐Cumulenols.
Authors: Ferrand Laura , Das Neves Nicolas , Malacria Max , Mouries‐Mansuy Virginie , Ollivier Cyril , Fensterbank Louis 
Published: January 2016

AbstractThe two‐step, one‐pot protocol for the coupling of 1,3‐butadiynes with aldehydes by subsequent gold(I)‐catalyzed cycloisomerization furnishes furan derivatives via tetrafunctionalized [3]‐cumulenol intermediates.
ChemInform Abstract: Successive Cu/Pd Transmetalation Relay Catalysis in Stereoselective Synthesis of Tetraarylethenes.
Authors: Song Chuanling , Sun Yihua , Wang Jianwu , Chen Hui , Yao Jiannian , Tung Chen‐Ho , Xu Zhenghu 
Published: January 2016

AbstractTetrasubstituted olefins are prepared as a single stereoisomers by a Cu/Pd‐catalyzed isomerization/insertion/oxidative coupling cascade reaction of cyclopropenes with internal alkynes.
ChemInform Abstract: Aqueous Titanium Trichloride Promoted Reductive Cyclization of o‐Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine.
Authors: Tong Shuo , Xu Zhengren , Mamboury Mathias , Wang Qian , Zhu Jieping 
Published: January 2016

AbstractThe title reaction offers a straightforward synthesis of functionalized indoles from structurally diverse o‐nitrostyrenes.
ChemInform Abstract: One‐Pot Three‐Component Reactions of Methyl Ketones, Phenols and a Nucleophile: An Expedient Way to Synthesize Densely Substituted Benzofurans.
Authors: Cheng Cheng , Liu Changhui , Gu Yanlong 
Published: January 2016

AbstractOther nucleophiles, such as 1,2,4‐trimethoxybenzene and thiophenol, can also be utilized instead of the indole component.
ChemInform Abstract: (Z)‐Stereoselective Synthesis of Mono‐ and Bis‐heterocyclic Benzimidazol‐2‐ones via Cascade Processes Coupled with the Ugi Multicomponent Reaction.
Authors: Xu Zhigang , Martinez‐Ariza Guillermo , Cappelli Alexandra P. , Roberts Sue A. , Hulme Christopher 
Published: January 2016

AbstractThe acid treatment of various Ugi adducts afford 1,5‐benzodiazepines which subsequently undergo a rearrangement affording benzimidazolones.
ChemInform Abstract: Synthesis of 3‐Substituted 2‐Aminochromones via Sn(IV)‐Promoted Annulation of Ynamides with 2‐Methoxyaroyl Chlorides.
Authors: Liu Hongxu , Yang Yanyan , Wang Shen , Wu Jie , Wang Xiao‐Na , Chang Junbiao 
Published: January 2016

AbstractThis tandem Friedel—Crafts acylation/oxo‐Michael addition/elimination strategy provides a general access to 2‐aminochromones under mild conditions and tolerates a wide range of functional groups.
ChemInform Abstract: Facile Construction of Novel Heterocyclic Compounds: Three‐Component, One‐Pot Synthesis of 2‐Hydroxybenzoyl‐1,2‐dihydropyridine‐3‐carboxylates, Ketones, Pyridone‐3‐carboxylates and Benzopyrido‐1,3‐oxazole‐4‐carboxylates.
Authors: Rajkumar Kommera , Suman Pathi , Raju Bhimapaka China 
Published: January 2016

AbstractThis facile and catalyst‐free method furnishes various biologically interesting heterocyclic compounds by a three‐component, one‐pot approach.
ChemInform Abstract: Regioselective, Molecular Iodine‐Mediated C3 Iodination of Quinolines.
Authors: Sun Kai , Lv Yunhe , Wang Junjie , Sun Jingjing , Liu Lulu , Jia Mingyang , Liu Xin , Li Zhenduo , Wang Xin 
Published: January 2016

AbstractThis method allows the regioselective C3 iodination of quinolines on gram scale with good yields.
ChemInform Abstract: Access to Highly Substituted 7‐Azaindoles from 2‐Fluoropyridines via 7‐Azaindoline Intermediates.
Authors: Nuhant Philippe , Allais Christophe , Chen Ming Z. , Coe Jotham W. , Dermenci Alpay , Fadeyi Olugbeminiyi O. , Flick Andrew C. , Mousseau James J. 
Published: January 2016

AbstractA sequence for the synthesis of 2‐fluoro‐3‐(2‐nitroethyl)pyridines and their reaction to 7‐azaindolines is presented.
ChemInform Abstract: Tandem 1,2‐Sulfur Migration and (Aza)‐Diels—Alder Reaction of β‐Thio‐α‐diazoimines: Rhodium Catalyzed Synthesis of (Fused)‐Polyhydropyridines, and Cyclohexenes.
Authors: Yadagiri Dongari , Anbarasan Pazhamalai 
Published: January 2016

AbstractThe title reaction proceeds via 1‐azadiene (II) intermediate, which undergoes self aza‐Diels—Alder reaction and subsequent 1,2‐sulfur migration to give tetrahydropyridines [e.g. (III)].
ChemInform Abstract: Rhodium(III)‐Catalyzed Annulation of 2‐Arylimidazo[1,2‐a]pyridines and Alkynes via Direct Double C—H Activation.
Authors: Wang Wei , Niu Jun‐Long , Liu Wen‐Bo , Shi Tan‐Hao , Hao Xin‐Qi , Song Mao‐Ping 
Published: January 2016

AbstractA series of naphthoimidazo[1,2‐a]pyridines is smoothly synthesized by rhodium‐catalyzed reaction of 2‐arylimidazo[1,2‐a]pyridines with symmetrical and unsymmetrical alkynes.
ChemInform Abstract: Stereoselective Synthesis of Hernandulcin, Peroxylippidulcine A, Lippidulcines A, B and C and Taste Evaluation.
Authors: Rigamonti Marco Giulio , Gatti Francesco Gilberto 
Published: January 2016

AbstractThe first stereoselective synthesis of peroxylippidulcine A (IIa) and lippidulcines A (IIb), B (III), and C (IV) is described.
ChemInform Abstract: Diterpenes from the Roots of Oryza sativa L. and Their Inhibition Activity on NO Production in LPS‐Stimulated RAW264.7 Macrophages.
Authors: Baek Nam‐In , et al.  
Published: January 2016

Abstractisolation, structure elucidation and bioactivity of two new pimarane diterpenoids, momilactone D (I) and E (II), along with three known diterpenoids
Impaired mitochondrial function is abrogated by dexrazoxane in doxorubicin‐treated childhood acute lymphoblastic leukemia survivors
Authors: Lipshultz Steven E. , Anderson Lynn M. , Miller Tracie L. , Gerschenson Mariana , Stevenson Kristen E. , Neuberg Donna S. , Franco Vivian I. , LiButti Daniel E. , Silverman Lewis B. , Vrooman Lynda M. , Sallan Stephen E. ,   for the Dana‐Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium
Published: January 2016

BACKGROUNDImpaired cardiac function in doxorubicin‐treated childhood cancer survivors is partly mediated by the disruption of mitochondrial energy production. Doxorubicin intercalates into mitochondrial DNA (mtDNA) and disrupts genes encoding for polypeptides that make adenosine triphosphate.METHODSThis cross‐sectional study examined mtDNA copy numbers per cell and oxidative phosphorylation (OXPHOS) in peripheral blood mononuclear cells (PBMCs) in 64 childhood survivors of high‐risk acute lymphoblastic leukemia (ALL) who had been treated on Dana‐Farber Cancer Institute childhood ALL protocols and had received doxorubicin alone (42%) or doxorubicin with the cardioprotectant dexrazoxane (58%). The number of mtDNA copies per cell and the OXPHOS enzyme activity of nicotinamide adenine dinucleotide dehydrogenase (complex I [CI]) and cytochrome c oxidase (complex IV [CIV]) were measured with quantitative real‐time polymerase chain reaction immunoassays and thin‐layer chromatography, respectively.RESULTSAt a median follow‐up of 7.8 years after treatment, the median number of mtDNA copies per cell for patients treated with doxorubicin alone (1106.3) was significantly higher than the median number for those who had also received dexrazoxane (310.5; P = .001). No significant differences were detected between the groups for CI or CIV activity.CONCLUSIONSDoxorubicin‐treated survivors had an increased number of PBMC mtDNA copies per cell, and concomitant use of dexrazoxane was associated with a lower number of mtDNA copies per cell. Because of a possible compensatory increase in mtDNA copies per cell to maintain mitochondrial function in the setting of mitochondrial dysfunction, overall OXPHOS activity was not different between the groups. The long‐term sustainability of this compensatory response in these survivors at risk for cardiac dysfunction over their lifespan is concerning. Cancer 2016;122:946–53. © 2016 American Cancer Society.
Organization of projection neurons and local neurons of the primary auditory center in the fruit flyDrosophila melanogaster
Authors: Matsuo Eriko , Seki Haruyoshi , Asai Tomonori , Morimoto Takako , Miyakawa Hiroyoshi , Ito Kei , Kamikouchi Azusa 
Published: January 2016

ABSTRACTAcoustic communication between insects serves as an excellent model system for analyzing the neuronal mechanisms underlying auditory information processing. The detailed organization of auditory neural circuits in the brain has not yet been described. To understand the central auditory pathways, we used the brain of the fruit flyDrosophila melanogasteras a model and performed a large‐scale analysis of the interneurons associated with the primary auditory center. By screening expression driver strains and performing single‐cell labeling of these strains, we identified 44 types of interneurons innervating the primary auditory center. Five types were local interneurons whereas the other 39 types were projection interneurons connecting the primary auditory center with other brain regions. The projection neurons comprised three frequency‐selective pathways and two frequency‐embracive pathways. Mapping of their connection targets revealed that five neuropils in the brain—the wedge (WED), anterior ventrolateral protocerebrum, posterior ventrolateral protocerebrum (PVLP), saddle (SAD), and gnathal ganglia (GNG)—were intensively connected with the primary auditory center. In addition, several other neuropils, including visual and olfactory centers in the brain, were directly connected to the primary auditory center. The distribution patterns of the spines and boutons of the identified neurons suggest that auditory information is sent mainly from the primary auditory center to the PVLP, WED, SAD, GNG, and thoracico‐abdominal ganglia. Based on these findings, we established the first comprehensive map of secondary auditory interneurons, which indicates the downstream information flow to parallel ascending pathways, multimodal pathways, and descending pathways. J. Comp. Neurol. 524:1099–1164, 2016. © 2016 Wiley Periodicals, Inc.
High‐Pressure Raman and Calorimetry Studies of Vanadium(III) Alkyl Hydrides for Kubas‐Type Hydrogen Storage
Authors: Morris Leah , Trudeau Michel L. , Reed Daniel , Book David , Antonelli David M. 
Published: January 2016

AbstractReversible hydrogen storage under ambient conditions has been identified as a major bottleneck in enabling a future hydrogen economy. Herein, we report an amorphous vanadium(III) alkyl hydride gel that binds hydrogen through the Kubas interaction. The material possesses a gravimetric adsorption capacity of 5.42 wt % H2 at 120 bar and 298 K reversibly at saturation with no loss of capacity after ten cycles. This corresponds to a volumetric capacity of 75.4 kgH2 m−3. Raman experiments at 100 bar confirm that Kubas binding is involved in the adsorption mechanism. The material possesses an enthalpy of H2 adsorption of +0.52 kJ mol−1 H2, as measured directly by calorimetry, and this is practical for use in a vehicles without a complex heat management system.
Diffusion of Oligonucleotides from within Iron‐Cross‐Linked, Polyelectrolyte‐Modified Alginate Beads: A Model System for Drug Release
Authors: Privman Vladimir , Domanskyi Sergii , Luz Roberto A. S. , Guz Nataliia , Glasser M. Lawrence , Katz Evgeny 
Published: January 2016

AbstractAn analytical model to describe diffusion of oligonucleotides from stable hydrogel beads is developed and experimentally verified. The synthesized alginate beads are Fe3+‐cross‐linked and polyelectrolyte‐doped for uniformity and stability at physiological pH. Data on diffusion of oligonucleotides from inside the beads provide physical insights into the volume nature of the immobilization of a fraction of oligonucleotides due to polyelectrolyte cross‐linking, that is, the absence of a surface‐layer barrier in this case. Furthermore, the results suggest a new simple approach to measuring the diffusion coefficient of mobile oligonucleotide molecules inside hydrogels. The considered alginate beads provide a model for a well‐defined component in drug‐release systems and for the oligonucleotide‐release transduction steps in drug‐delivering and biocomputing applications. This is illustrated by destabilizing the beads with citrate, which induces full oligonucleotide release with nondiffusional kinetics.
Visible‐Light‐Driven Water Oxidation on a Photoanode by Supramolecular Assembly of Photosensitizer and Catalyst
Authors: Li Hua , Li Fei , Wang Yong , Bai Lichen , Yu Fengshou , Sun Licheng 
Published: January 2016

AbstractA ruthenium water oxidation catalyst (WOC) bearing hydrophobic ligands was incorporated on the surface of a dye‐sensitized nanostructured TiO2 film by formation of a host–guest adduct with the dye. This provides a new strategy for constructing photocatalytically active electrodes for water oxidation. The resultant photoanode exhibits a photocurrent of 800 μA cm−2 under visible‐light illumination (λ>400 nm, 300 mW cm−2) and 240 μA cm−2 under simulated sunlight illumination (AM 1.5G, 100 mW cm−2) with an applied bias of 0.2 V vs. NHE in neutral phosphate buffer.
Ammonia Decomposition with Manganese Nitride–Calcium Imide Composites as Efficient Catalysts
Authors: Yu Pei , Guo Jianping , Liu Lin , Wang Peikun , Wu Guotao , Chang Fei , Chen Ping 
Published: January 2016

AbstractAmmonia has high gravimetric and volumetric hydrogen densities and is, therefore, considered a promising carrier for the production of COx‐free molecular H2 for forthcoming energy systems. Alkaline earth metals are generally regarded as structural promoters of catalysts and employed in numerous catalytic processes. Here, we report that calcium imide (CaNH) has a strong synergistic effect on Mn6N5 in catalyzing the decomposition of NH3, leading to a ca. 40 % drop in apparent activation energy. At 773 K, the H2 formation rate over a Mn6N5‐11CaNH composite catalyst is about an order of magnitude higher than that of Mn6N5 and comparable to the highly active Ni/SBA‐15 and Ru/Al2O3 catalysts. Analysis by means of temperature‐programmed decomposition (TPD), X‐ray diffraction (XRD), and X‐ray absorption near edge spectroscopy (XANES) reveal that CaNH participates in the catalysis via forming a [Ca6MnN5]‐like intermediate, thus altering the reaction pathway and energetics. A two‐step catalytic cycle, accounting for the synergy between CaNH and Mn6N5, is proposed.
Antihyperalgesic Activity ofRhodiolaroseain a Diabetic Rat Model
Authors: Déciga‐Campos Myrna , González‐Trujano Maria Eva , Ventura‐Martínez Rosa , Montiel‐Ruiz Rosa Mariana , Ángeles‐López Guadalupe Esther , Brindis Fernando 
Published: January 2016

ABSTRACTPreclinical ResearchRhodiola rosea L. (Crassulaceae) is used for enhancing physical and mental performance. Recent studies demonstrated thatR. roseahad anti‐inflammatory activity in animal models, for example, carrageenan‐ and nystatin‐induced edema in rats, possibly by inhibiting phospholipase A2and cyclooxygenases‐1 and ‐2. In addition,R. roseahad antinociceptive activity in thermal and chemical pain tests as well as mechanical hyperalgesia. The purpose of the present study was to assess the antihyperalgesic effect of an ethanol extract ofRhodiola rosea(R. rosea) in a diabetic rat model. Rats were administered a single dose ofstreptozotocin (STZ; 50 mg/kg, i.p.) and hyperalgesia was evaluated four weeks later. Formalin‐evoked (0.5%) flinching was increased in diabetic rats compared with nondiabetic controls Systemic (1–100 mg/kg, i.p.) and local (0.1–10 mg/paw into the dorsal surface of the right hind paw) administration ofR. roseaethanol extract dose‐dependently reduced formalin‐induced hyperalgesia in diabetic rats. The antihyperalgesic effect ofR. roseawas compared with gabapentin. These results suggest thatR. roseaethanol extract may have potential as a treatment for diabetic hyperalgesia. Drug Dev Res 77 : 29–36, 2016. © 2016 Wiley Periodicals, Inc.
Synthesis of p‐O‐Alkyl Salicylanilide Derivatives as Novel EGFR Inhibitors
Authors: Zhang Li , Hou Lin , Sun Wenyan , Yu Zidong , Wang Jibo , Gao Hua , Yang Guiming 
Published: January 2016

ABSTRACT

Preclinical Research

Epidermal growth factor receptor (EGFR), a validated target for anticancer drugs, plays a critical role in tumorigenesis and tumor development. A series of p‐O‐alkyl salicylanilide derivatives were designed and synthesized as novel EGFR inhibitors using a salicylic acid scaffold. A simulated six‐membered ring strategy formed through intramolecular hydrogen bonds was employed to mimic the planar quinazoline of the EGFR antagonist, gefitinib. The derived compounds with hydroxyl at the ortho position were more potent than ones with methoxyl group. In particular, compounds 5d and 5b displayed significant EGFR inhibitory (IC50 values = 0.30 and 0.45 μM, respectively) activity as well as potent antiproliferative activity in A431 and HCT‐116 tumor cells. These salicylanilides could be considered as promising lead compounds for developing novel EGFR inhibitors. Drug Dev Res 77 : 37–42, 2016. © 2016 Wiley Periodicals, Inc.
Significance of myocardial tenascin‐C expression in left ventricular remodelling and long‐term outcome in patients with dilated cardiomyopathy
Authors: Yokokawa Tetsuro , Sugano Yasuo , Nakayama Takafumi , Nagai Toshiyuki , Matsuyama Taka‐aki , Ohta‐Ogo Keiko , Ikeda Yoshihiko , Ishibashi‐Ueda Hatsue , Nakatani Takeshi , Yasuda Satoshi , Takeishi Yasuchika , Ogawa Hisao , Anzai Toshihisa 
Published: January 2016

AimDilated cardiomyopathy (DCM) has a variety of causes, and no useful approach to predict left ventricular (LV) remodelling and long‐term outcome has yet been established. Myocardial tenascin‐C (TNC) is known to appear under pathological conditions, possibly to regulate cardiac remodelling. The aim of this study was to clarify the significance of myocardial TNC expression in LV remodelling and the long‐term outcome in DCM.Methods and resultsOne hundred and twenty‐three consecutive DCM patients who underwent endomyocardial biopsy for initial diagnosis were studied. Expression of TNC in biopsy sections was analysed immunohistochemically to quantify the ratio of the TNC‐positive area to the whole myocardial tissue area (TNC area). Clinical parameters associated with TNC area were investigated. The patients were divided into two groups based on receiver operating characteristic analysis of TNC area to predict death: high TNC group with TNC area ≥2.3% (22 patients) and low TNC group with TNC area <2.3% (101 patients). High TNC was associated with diabetes mellitus. Comparing echocardiographic findings between before and 9 months after endomyocardial biopsy, the low TNC group was associated with decreased LV end‐diastolic diameter and increased LV ejection fraction, whereas the high TNC group was not. Survival analysis revealed a worse outcome in the high TNC group than in the low TNC group (P < 0.001). Multivariable Cox regression analysis revealed that TNC area was independently associated with poor outcome (HR = 1.347, P = 0.032).ConclusionsIncreased myocardial TNC expression was associated with worse LV remodeling and long‐term outcome in DCM.