bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Media Pembelajaran Berbasis Audio Visual Tokoh-Tokoh Kemerdekaan Indonesia
Authors: Salamah Evi Rizqi 
Published: July 2017

<p>Penelitian pengembangan media berbasis audio visual ini dilatarbelakangi terdapatnya hasil belajar siswa yang rendah tentang tokoh-tokoh kemerdekaan Indonesia. Oleh karena itu tujuan dari penelitian dan pengembangan media berbasis audio visual ini adalah untuk meningkatkan hasil belajar siswa sekolah dasar tentang tokoh-tokoh kemerdekaan. desain penelitian dan pengembangan media berbasis audio visual menggunakan model brog and gall yang diadaptasi dari dick and carey. Hasil penelitian dan pengembangan media menunjukkan bahwa skor hasil belajar siswa meningkat sesudah menggunakan media berbasis audio visual, hasil pretest kelompok eksperimen adalah 50.45 dan hasil posttest 85.75. Sedangkan hasil pretest kelompok kontrol adalah 58.45 dan posttest adalah 90.35. Dari penelitian pengembangan ini dapat disimpulkan bahwa media berbasis audio visual dapat meningkatkan hasil belajar siswa.</p>
DISEÑO DE UN MODELO DE GESTIÓN POR PROCESOS: CARRERA DE ADMINISTRACIÓN DE EMPRESAS- ESPAM MFL
Authors: Márquez Bravo Yessenia Johana , Valarezo Beltrón Carlos Oswaldo , Saltos Solórzano Julio Vinicio , Palacios Zurita Wladimir Alexander 
Published: July 2017

Esta investigación tuvo como objetivo diseñar un modelo de gestión por procesos para la carrera Administración de Empresas de la ESPAM MFL, que contribuya al perfeccionamiento de los procesos agregadores de valor en la formación profesional de los estudiantes. Este modelo de gestión por procesos busca la mejora administrativa y operativa por lo cual se formularon indicadores para cada subproceso para medir su eficiencia y eficacia y que generen la toma adecuada de decisiones en la carrera de Administración de Empresas. Palabras Claves: Procesos, mapa de procesos, diagramas de flujo, indicadores. ABSTRACTThis study aimed to design a process management model for the Business Management career in ESPAM MFL, which contributes to improve the value adding processes in the professional training of students. This model of process management seeks administrative and operational improvement indicators for which each thread is made to measure efficiency and effectiveness and generate decisions in the career of Business Administration. Keywords: Processes, process map, flowchart, indicators.
LA FORMACIÓN PROFESIONAL DEL CONTADOR Y SU APORTE EN EL DESARROLLO DE LA GESTIÓN EMPRESARIAL EN LAS ENTIDADES DE LA PROVINCIA DE SANTA ELENA
Authors: Pico Gutiérrez Eduardo , Loor María Carmen 
Published: July 2017

El objetivo fundamental del estudio es socializar el aporte de la formación profesional del contador a través de una investigación de campo que contribuya al desarrollo de la gestión empresarial en las organizaciones la provincia de Santa Elena, cuyo crecimiento intelectual de la población se multiplicó con la apertura del alma mater peninsular, se incrementaron los emprendimientos empresariales y se fortalecieron muchas organizaciones con los nuevos profesionales incorporados en la Universidad, el ámbito de acción de los contadores se expandió por la efectiva decisión del gobierno de recaudar mejor los impuestos y crear en la gente la cultura tributaria, que fomenta una concientización sostenible de la sociedad, consecuentemente tanto las personas naturales como los empresarios que tienen diversidad de negocios requieren de los servicios profesionales de los contadores para hacer sus declaraciones, llevar registros contables organizados, elaborar presupuestos, entre otras actividades que empresas públicas y privadas, así como también profesionales de otras especialidades requieren los servicios de los contadores y su aporte se torna más significativo y pertinente para la comunidad peninsular.Palabras Clave: Formación profesional, gestión empresarial, impuestos, emprendimientos, declaraciones. ABSTRACTThe main objective of this study is to socialize the contribution of vocational training of an accountant through field research that contributes to the development of business management in the organizations in the province of Santa Elena, whose intellectual growth of the population was multiplied with the opening of the university in Santa Elena. Entrepreneurship increased and many organizations with new professionals graduated in the university. The scope of accountants expanded due to the effective decision of the government to collect taxes better and create a tax culture, which promotes sustainable awareness of society; consequently, both natural persons and entrepreneurs who have diverse businesses require services of professional accountants to make tax declarations, perform organized accounting records, elaborate budgets, among other activities that public and private companies as well as professionals from other specialties need and their contribution becomes more meaningful and relevant to the community.Keywords: Professional Education, bussines managment, taxes, enterprises, tax declarations.
MODELO PEDAGÓGICO DE EDUCACIÓN FAMILIAR PARA PADRES DE ESCOLARES CON DISCAPACIDAD FÍSICO-MOTORA
Authors: Bert Valdespino Juana Emilia , Urías Arbolaez Graciela De la Caridad , Pino Torrens Ricardo Enrique , Molerio Rosa. Liliana 
Published: July 2017

La familia debe constituir el primer contexto de inclusión socioeducativa, que todo niño necesita para crecer feliz. Los cambios que provoca la discapacidad físico-motriz al interior de la familia genera necesidades emocionales. El presente artículo presenta resultados de una investigación que se desarrolló en el ámbito de la Educación Especial cubana, la que tiene como línea base la Atención Educativa Integral e Inclusiva de los escolares, adolescentes y jóvenes con discapacidad físico-motriz, con el concurso y la participación activa de la familia en unidad con la escuela y la comunidad. El objetivo que se pretende con el siguiente artículo es presentar un Modelo Pedagógico de Educación Familiar mediante la Orientación Psicopedagógica, para el logro de Padres Potenciadores del desarrollo integral de sus hijos con discapacidad físico-motriz.Palabras claves: educación familiar, modelo pedagógico, desarrollo automotriz ABSTRACTThe family should be the first context of socio-educational inclusion, which every child needs to grow up happy. The changes caused by the physical-motor disability within the family generate emotional needs. This article presents the results of an investigation carried out in the area of Cuban Special Education, which has as its base line the Integral and Inclusive Educational Care of schoolchildren, adolescents and young people with physical and motor disabilities, with the contest and the Active participation of the family in unity with the school and the community. The objective of the next article is to present a Pedagogical Model of Family Education through the Psychopedagogical Orientation, for the achievement of Foster Parents of the integral development of their children with physical and motor disabilities.Keywords: family education, pedagogical model, automotive development
Contralateral C-7 transfer: is direct repair really superior to grafting?
Authors: Bhatia Anil , Doshi Piyush , Koul Ashok , Shah Vitrag , Brown Justin M. , Salama Mahmoud 
Published: July 2017

It is not uncommon for a severe traumatic brachial plexus injury to involve all 5 roots, resulting in a flail upper limb. In such cases, surgical reconstruction is often palliative, providing only rudimentary function. Nerve transfers are the mainstay of reconstructive strategies due to the predominance of root avulsions. Consistent results are obtained only for restoration of shoulder stability and elbow flexion, whereas restoring useful hand function remains a challenge. The transfer of the contralateral C-7 (cC-7) is commonly used in an attempt to restore basic hand function, but results are notoriously unreliable and inconsistent. Shu-feng Wang and colleagues recently proposed a potentially more successful permutation of this procedure. They advocated direct approximation of the cC-7 to the lower trunk on the paralyzed side, thus avoiding the interposition of nerve grafts. This technique involves a lengthy dissection of the cC-7 transfer across the midline via a prespinal route, as well as extensive mobilization of the ipsilateral lower trunk by cutting a subset of its branches, adducting the arm, and (if necessary) shortening the humerus. Each of these steps is indispensable to achieve direct approximation of the nerve ends. Many surgeons have tried to emulate Wang’s strategy. However, the technical difficulties involved have forced recourse to interposition of nerve grafts once again.The authors report their observations in the first 22 patients in whom they performed this procedure. Direct cC-7 repair via the prespinal route was performed in 12 patients. Shortening of the humerus was necessary in 9 of these 12 patients. In 10 patients, a direct repair was not feasible and nerve grafting was performed. The median follow-up period was 26 months for the direct coaptation group and 28.5 months for the nerve graft group.In the direct repair group, 10 of the 12 patients regained Medical Research Council Grade 3 flexion of the wrist and of the middle, ring, and little fingers, while the remaining 2 patients had Grade 2 function. Flexion appeared 12–14 months after the operation. At the latest follow-up, these patients could activate the wrist and hand without requiring significant augmentation maneuvers in the donor limb. In contrast, repair requiring interposition grafts resulted in Grade 3 strength in only 2 of 10 patients, while 7 had Grade 2 strength, and 1 experienced failure. In all grafted cases, the patient had to forcibly contract the contralateral pectoralis major and triceps muscles to produce the weak movements on the reconstructed side.In this small series, the authors demonstrated a distinct advantage associated with the avoidance of grafts when transferring the cC-7 to restore hand function. The authors conclude that efforts to achieve direct approximation of the donor C-7 and the recipient lower trunk are necessary and justified.
The paramedian supracerebellar-transtentorial approach to remove a posterior fusiform gyrus arteriovenous malformation
Authors: Harput Mehmet Volkan , Türe Uğur 
Published: July 2017

This is the case of a 14-year-old female who presented with headache and seizures. Cranial magnetic resonance imaging revealed an arteriovenous malformation (AVM) located at the posterior portion of the right-sided fusiform gyrus. Cerebral angiography showed that the AVM was fed mainly by branches from the inferior temporal trunk of the posterior cerebral artery. The main venous drainage was to the right transverse sinus through the tentorial vein. The AVM was totally excised through the paramedian supracerebellar-transtentorial approach with the patient in a semisitting position. Postoperative MRI and cerebral angiography confirmed the total resection. The patient was discharged on the 5th postoperative day without neurological deficit.The video can be found here: https://youtu.be/QPrUl8AP7G8.
Navigation-guided transsylvian approach and microsurgical resection of a deep left temporal low-grade arteriovenous malformation
Authors: Couldwell William T. 
Published: July 2017

This video demonstrates stereotactic-guided resection of a ruptured diffuse left temporal arteriovenous malformation (AVM) in an adolescent male who presented with headache and speech difficulties. The diffuse nidus of the AVM, 25 mm in size, was located in the posterior superior temporal gyrus, with drainage into the sylvian veins (Spetzler-Martin Grade II). The AVM was located stereotactically, and resection was performed through a small corticectomy. The clot cavity was evacuated. Feeding branches to the AVM were identified during careful dissection, and parent M1 and M2 branches were preserved. The patient recovered well, with no residual speech deficit. Postoperative angiogram demonstrated complete AVM removal.The video can be found here: https://youtu.be/Sttc86H8jCw.
Utility of indocyanine green videoangiography in subcortical arteriovenous malformation resection
Authors: Rustemi Oriela , Scienza Renato , Della Puppa Alessandro 
Published: July 2017

Subcortical arteriovenous malformations (AVMs) are surgically challenging. Localization is crucial for eloquent areas, and complete resection evaluation is uncertain. Indocyanine green videoangiography (ICG-VA) can assist this surgery. An illustrative video of a subcortical frontoparietal bleeding AVM resection assisted by ICG-VA is presented. A bleeding arterial feeder aneurysm was embolized in the acute phase to protect against rebleeding. ICG-VA helped to detect the AVM’s superficial arterialized draining vein, distinguishing it from normal cortical veins. This enabled a customized sulcus approach. ICG-VA showed normalized flow through the previously arterialized vein, confirming the AVM’s complete resection. This applies when there is a single drainage remaining.The video can be found here: https://youtu.be/L7yJEE66kV0.
An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis
Authors: Bossini-Castillo Lara , Campillo-Davó Diana , López-Isac Elena , Carmona Francisco David , Simeon Carmen P. , Carreira Patricia , Callejas-Rubio José Luis , Castellví Iván , Fernández-Nebro Antonio , Rodríguez-Rodríguez Luis , Rubio-Rivas Manel , García-Hernández Francisco J. , Madroñero Ana Belén , Beretta Lorenzo , Santaniello Alessandro , Lunardi Claudio , Airó Paolo , Hoffmann-Vold Anna-Maria , Kreuter Alexander , Riemekasten Gabriela , Witte Torsten , Hunzelmann Nicolas , Vonk Madelon C. , Voskuyl Alexandre E. , de Vries-Bouwstra J. , Shiels Paul , Herrick Ariane , Worthington Jane , Radstake Timothy R.D.J. , Martin Javier ,   The Spanish Scleroderma Group
Published: July 2017

Objective.Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to review the association of the MIF gene, which encodes a cytokine implicated in idiopathic pulmonary hypertension among other diseases, with the susceptibility and clinical expression of SSc, in addition to testing the association of this polymorphism with SSc-related pulmonary involvement.Methods.A total of 4392 patients with SSc and 16,591 unaffected controls from 6 cohorts of European origin were genotyped for the MIF promoter variant rs755622. An inverse variance method was used to metaanalyze the data.Results.A statistically significant increase of the MIF rs755622*C allele frequency compared with controls was observed in the subgroups of patients with diffuse cutaneous SSc (dcSSc) and with pulmonary arterial hypertension (PAH) independently (dcSSc: p = 3.20E–2, OR 1.13; PAH: p = 2.19E–02, OR 1.32). However, our data revealed a stronger effect size with the subset of patients with SSc showing both clinical manifestations (dcSSc with PAH: p = 6.91E–3, OR 2.05).Conclusion.We reviewed the association of the MIF rs755622*C allele with SSc and described a phenotype-specific association of this variant with the susceptibility to develop PAH in patients with dcSSc.
Leukotriene C4 Potentiates IL-33–Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation
Authors: Lund Sean J. , Portillo Alex , Cavagnero Kellen , Baum Rachel E. , Naji Luay H. , Badrani Jana H. , Mehta Amit , Croft Michael , Broide David H. , Doherty Taylor A. 
Published: July 2017

Abstract
Asthma is a complex disease that is promoted by dysregulated immunity and the presence of many cytokine and lipid mediators. Despite this, there is a paucity of data demonstrating the combined effects of multiple mediators in asthma pathogenesis. Group 2 innate lymphoid cells (ILC2s) have recently been shown to play important roles in the initiation of allergic inflammation; however, it is unclear whether lipid mediators, such as cysteinyl leukotrienes (CysLTs), which are present in asthma, could further amplify the effects of IL-33 on ILC2 activation and lung inflammation. In this article, we show that airway challenges with the parent CysLT, leukotriene C4 (LTC4), given in combination with low-dose IL-33 to naive wild-type mice, led to synergistic increases in airway Th2 cytokines, eosinophilia, and peribronchial inflammation compared with IL-33 alone. Further, the numbers of proliferating and cytokine-producing lung ILC2s were increased after challenge with both LTC4 and IL-33. Levels of CysLT1R, CysLT2R, and candidate leukotriene E4 receptor P2Y12 mRNAs were increased in ILC2s. The synergistic effect of LTC4 with IL-33 was completely dependent upon CysLT1R, because CysLT1R−/− mice, but not CysLT2R−/− mice, had abrogated responses. Further, CysLTs directly potentiated IL-5 and IL-13 production from purified ILC2s stimulated with IL-33 and resulted in NFAT1 nuclear translocation. Finally, CysLT1R−/− mice had reduced lung eosinophils and ILC2 responses after exposure to the fungal allergen Alternaria alternata. Thus, CysLT1R promotes LTC4- and Alternaria-induced ILC2 activation and lung inflammation. These findings suggest that multiple pathways likely exist in asthma to activate ILC2s and propagate inflammatory responses.
Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt
Authors: He Zhiheng , Wang Fei , Zhang Jing , Sen Subha , Pang Qihua , Luo Shengwei , Gwack Yousang , Sun Zuoming 
Published: July 2017

Abstract
Transcription factor retinoid acid–related orphan receptor (ROR)γt transcriptionally regulates the genes required for differentiation of Th17 cells that mediate both protective and pathogenic immunity. However, little is known about the function of posttranslational modifications in the regulation of RORγt activity. Mass spectrometric analysis of immunoprecipitated RORγt from Th17 cells identified multiple phosphorylation sites. Systematic mutation analysis of the identified phosphorylation sites found that phosphorylation of S376 enhances whereas phosphorylation of S484 inhibits Th17 differentiation. IκB kinase (IKK)α binds and phosphorylates RORγt at S376 but not S484. Knockdown of IKKα, dominant-negative IKKα, and RORγt mutants incapable of interacting with IKKα all decrease Th17 differentiation. Furthermore, nonphosophorylatable RORγt mutant (S376A) impairs whereas phosphomimetic mutant (S376E) stimulates Th17 differentiation independent of IKKα. Therefore, IKKα-dependent phosphorylation of S376 stimulated whereas IKKα-independent phosphorylation of S484 inhibited RORγt function in Th17 differentiation.
Mantle dynamics beneath the discrete and diffuse plate boundaries of the Juan de Fuca plate: Results from Cascadia Initiative body wave tomography
Authors: Byrnes Joseph S. , Toomey Douglas R. , Hooft Emilie E. E. , Nábělek John , Braunmiller Jochen 
Published: July 2017

AbstractWe use the delay times of teleseismic S phases recorded by ocean bottom seismometers during the plate‐scale Cascadia Initiative community experiment to constrain the heterogeneity of seismic velocity structure beneath young oceanic lithosphere. Our study area covers the entire Juan de Fuca (JdF) and Gorda plates, from their creation at the JdF and Gorda Ridges to their subduction beneath the North American continent, and the entire length of the Blanco transform fault. The range of the observed Vs anomalies requires variations in the melt fraction of the asthenosphere. The data require that low Vs anomalies extend to depths of at least 200 km, which is within the carbonatite melting regime. In the upper 200 km of the mantle, Vs increases rapidly to the east of the JdF Ridge, while there is no clear relationship with the age of the lithosphere in the Gorda region. The distribution of melt is asymmetric about both the JdF and Gorda Ridges. Dynamic upwelling – due to the buoyancy of the mantle – and accompanying downwelling can explain the rapid decrease in melt fraction to the east of the JdF Ridge, the asymmetry about the JdF Ridge, and the sinuous pattern of upwelling near the Blanco transform fault. Finally, mantle flow beneath the diffuse Gorda and Explorer plate boundaries is distinct from that beneath the discrete plate boundary of the JdF Ridge. In particular, shear between the Pacific and JdF plates appears to dominate mantle deformation over seafloor spreading beneath the Gorda Ridge.
Abdominal obesity in adolescents: Development of age‐specific waist circumference cut‐offs linked to adult IDF criteria
Authors: Bravo Jorge , Raimundo Armando M. , Santos Diana A. , Timón Rafael , Sardinha Luís B. 
Published: July 2017

AbstractObjectivesThe purpose of this study was to develop age‐ and sex‐specific waist circumference (WC) cut‐off points, linked to older adolescent and adult criteria for abdominal obesity, to be applied to children in the clinical setting.MethodsA total of 16,788 adolescents aged 10 to 16 years were assessed for WC. Smoothed age and sex‐specific WC curves were obtained using Cole's LMS method.ResultsPercentiles that corresponded to the International Diabetes Federation (IDF) recommendations used for older adolescents and adults (16+ years old) were the 97th percentile for boys and the 87th percentile for girls. Using these cutoffs, a total of 368 boys and 1138 girls were categorized as abdominally obese, in contrast to 1654 boys and 987 girls that were identified using the current IDF pediatric criteria (90th percentile).ConclusionsWe provide age‐ and sex‐specific cut‐off points that can be used to identify abdominal obesity in adolescents. The present findings provide a tool that can be used in the clinical setting for the early detection and prevention of adult obesity. Population‐specific cutoffs may be required for pediatric ages to diagnose children at risk.
Sexual and Regional Differences in Myosin Heavy Chain Expression in the Rat External Urethral Sphincter
Authors: Tsumori Toshiko , Tsumiyama Wakako 
Published: July 2017

ABSTRACTThe external urethral sphincter is a unique striated muscle surrounding the urethra that plays a crucial role in urinary continence, and a comprehensive understanding of its morphology is needed to determine the pathophysiology underlying urinary incontinence and find suitable therapies. Differences between the sexes and among species regarding the fiber types present remain controversial. This study used triple immunofluorescence labeling to visualize one slow (Type 1) and two fast (Types 2A and 2B) myosin isoforms in rat external urethral sphincters from both sexes. Type 2A fibers predominated throughout the sphincter and Type 2B fibers were restricted to the proximal one‐third of the external urethral sphincter in the female rats. Type 1 fibers were present adluminally and were concentrated in the proximal and distal segments of the sphincter. While most of the male external urethral sphincter comprised Type 2B fibers, Type 2A fibers intermingled among these fibers in the proximal one‐third of the sphincter, and a few Type 1 fibers were present that were restricted to the adluminal region of the proximal segment. The fiber‐type compositions and their areal densities changed in both sexes after gonadectomy. The areal density of the Type 1 fibers increased significantly in the ovariectomized females, especially in the distal segment. In the orchidectomized males, the areal densities of the Types 1 and 2A fibers increased significantly, but that of the Type 2B fibers decreased. These results indicate that myosin heavy chain expression in the rat external urethral sphincter is sexually dimorphic and shows regional differences. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:2058–2069, 2017. © 2017 Wiley Periodicals, Inc.