bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity
Authors: Bhansali Shobhit , Dutta Pinaki , Yadav Mukesh Kumar , Jain Ashish , Mudaliar Sunder , Hawkins Meredith , Kurpad Anura V. , Pahwa Deepak , Yadav Ashok Kumar , Sharma Ratti Ram , Jha Vivekanand , Marwaha Neelam , Bhansali Shipra , Bhansali Anil 
Published: July 2017

Abstract
Background
Insulin resistance and insulin deficiency are the cardinal defects in the pathogenesis of type 2 diabetes mellitus (T2DM). Despite the plethora of anti-diabetic medications, drugs specifically targeting the β-cells are still desired. Stem cell therapy has emerged as a novel therapeutics strategy to target β-cells; however, their mechanism of action has not been well defined. This study aims to examine the efficacy and safety of autologous bone marrow-derived mononuclear cells (ABM-MNCs) transplantation in T2DM, and explores the mechanistic insights into stem cells action through metabolic studies.

Methods
Seven T2DM patients with the duration of disease ≥5 years, receiving triple oral anti-diabetic drugs along with insulin (≥0.4 IU per kg per day) and HbA1c ≤ 7.5% (≤58.0 mmol/mol) were enrolled for ABM-MNCs administration through a targeted approach. The primary end-point was a reduction in insulin requirement by ≥50% from baseline, while maintaining HbA1c < 7.0% (<53.0 mmol/mol) with improvement in insulin secretion, and/or insulin sensitivity after ABM-MNCs transplantation.

Results
Six out of 7 (90%) patients achieved the primary end-point. At 6 months, there was a significant reduction in insulin requirement by 51% as compared to baseline (p < 0.003). This was accompanied by a significant increase in the 2nd phase C-peptide response during hyperglycemic clamp (p = 0.018), whereas there were no significant alterations in insulin sensitivity and glucose disposal rate during hyperinsulinemic–euglycemic clamp relative to the baseline. Other measures of β-cell indices like HOMA-β, and stimulated C-peptide response to glucagon and mixed meal tolerance test were non-contributory.

Conclusion
ABM-MNCs transplantation results in significant reduction in insulin doses and improvement in C-peptide response in patients with T2DM. Metabolic studies may be more useful than conventional indices to predict β-cell function in patients with advanced duration of T2DM.
Trial registration-Clinicaltrials.gov NCT01759823
Anesthesia Adverse Events Voluntarily Reported in the Veterans Health Administration and Lessons Learned
Authors: Neily Julia , Silla Elda S. , Sum-Ping Sam (John) T. , Reedy Roberta , Paull Douglas E. , Mazzia Lisa , Mills Peter D. , Hemphill Robin R. 
Published: July 2017

BACKGROUND:
Anesthesia providers have long been pioneers in patient safety. Despite remarkable efforts, anesthesia errors still occur, resulting in complications, injuries, and even death. The Veterans Health Administration (VHA) National Center of Patient Safety uses root cause analysis (RCA) to examine why system-related adverse events occur and how to prevent future similar events. This study describes the types of anesthesia adverse events reported in VHA hospitals and their root causes and preventative actions.

METHODS:
RCA reports from VHA hospitals from May 30, 2012, to May 1, 2015, were reviewed for root causes, severity of patient outcomes, and actions. These elements were coded by consensus and analyzed using descriptive statistics.

RESULTS:
During the study period, 3228 RCAs were submitted, of which 292 involved an anesthesia provider. Thirty-six of these were specific to anesthesia care. We reviewed these 36 RCA reports of adverse events specific to anesthesia care. Types of event included medication errors (28%, 10), regional blocks (14%, 5), airway management (14%, 5), skin integrity or position (11%, 4), other (11%, 4), consent issues (8%, 3), equipment (8%, 3), and intravenous access and anesthesia awareness (3%, 1 each). Of the 36 anesthesia events reported, 5 (14%) were identified as being catastrophic, 10 (28%) major, 12 (34%) moderate, and 9 (26%) minor. The majority of root causes identified a need for improved standardization of processes.

CONCLUSIONS:
This analysis points to the need for systemwide implementation of human factors engineering–based approaches to work toward further eliminating anesthesia-related adverse events. Such actions include standardization of processes, forcing functions, separating storage of look-alike sound-alike medications, limiting stock of high-risk medication strengths, bar coding medications, use of cognitive aids such as checklists, and high-fidelity simulation.
Echocardiographic Assessment of Mitral Stenosis Orifice Area: A Comparison of a Novel Three-Dimensional Method Versus Conventional Techniques
Authors: Karamnov Sergey , Burbano-Vera Nelson , Huang Chuan-Chin , Fox John A. , Shernan Stanton K. 
Published: July 2017

BACKGROUND:
A comprehensive evaluation of mitral stenosis (MS) severity commonly utilizes two-dimensional (2D) echocardiography techniques. However, the complex three-dimensional (3D) structure of the mitral valve (MV) poses challenges to accurate measurements of its orifice area by 2D imaging modalities. We aimed to assess MS severity by comparing measurements of the MV orifice area using conventional echocardiography methods to 3D orifice area (3DOA), a novel echocardiographic technique which minimizes geometric assumptions.

METHODS:
Routine 2D and 3D intraoperative transesophageal echocardiographic images from 26 adult cardiac surgery patients with at least moderate rheumatic MS were retrospectively reviewed. Measurements of the MV orifice area obtained by pressure half-time (PHT), proximal isovelocity surface area (PISA), continuity equation, and 3D planimetry were compared to those acquired using 3DOA.

RESULTS:
MV areas derived by PHT, PISA, continuity equation, 3D planimetry, and 3DOA (mean value ± standard deviation) were 1.12 ± 0.27, 1.03 ± 0.27, 1.16 ± 0.35, 0.97 ± 0.25, and 0.76 ± 0.21 cm2, respectively. Areas obtained from the 3DOA method were significantly smaller than areas derived from PHT (mean difference 0.35 cm2, P < .0001), PISA (mean difference: 0.28 cm2, P = .0002), continuity equation (mean difference: 0.43 cm2, P = .0015), and 3D planimetry (mean difference: 0.19 cm2, P < .0001). MV 3DOAs also identified a significantly greater percentage of patients with severe MS (88%) compared to PHT (31%, P = .006), PISA (42%, P = .01), and continuity equation (39%, P = .017) but not in comparison to 3D planimetry (62%, P = .165).

CONCLUSIONS:
Novel measures of the stenotic MV 3DOA in patients with rheumatic heart disease are significantly smaller than calculated values obtained by conventional methods and may be consistent with a higher incidence of severe MS compared to 2D techniques. Further investigation is warranted to determine the clinical relevance of 3D echocardiographic techniques used to measure MV area.
A Possible Extension of Henslowe's and Alleyn's Sussex Network?
Authors: Quinn Paul 
Published: July 2017

In the following note, I present evidence of a relationship between Edward Alleyn and the Sherley family of Wiston in Sussex. Through an examination of local archives, Henslowe’s diary, and other theatre history, the note argues that the ‘Edward Allen’ recorded in Anne Sherley’s will could be Edward Alleyn. In so doing, it suggests a connection between Alleyn and the Sherley brothers dramatized by Day, Rowley, and Wilkins in The Travels of the Three English Brothers (1607), and Henry Sherley, the author of The Martyred Soldier (1622/3).
Structural change and non-constant biased technical change
Authors: Cruz Edgar 
Published: July 2017

AbstractEmpirical evidence suggests that the differences in rates of technical progress across sectors are time-variant, implying that the bias in technological change is not constant. In this paper, we analyze the implications of this non-constant sectoral biased technical change for structural change and we assess whether this is an important factor behind structural transformations. To this end, we develop a multi-sectoral growth model where TFP growth rates across sectors are non-constant. We calibrate our model to match the development of the U.S. economy during the twentieth century. Our findings show that, by assuming non-constant biased technical change, a purely technological approach is able to replicate the sectoral transformations in the U.S. economy not only after but also prior to World War II.
Can removing the tax cap save Social Security?
Authors: Bagchi Shantanu 
Published: July 2017

AbstractThe maximum amount of earnings in a calendar year that can be taxed by Social Security is currently set at $118,500. In this paper, I examine if removing this cap can solve Social Security’s future budgetary problems. I find that when this cap is removed, benefits need to decline by less than 4% to keep Social Security solvent, compared to by almost 12% when the cap is held fixed at its current level. Households for whom the cap expires respond by working and saving less, which reduces labor supply, capital stock, and output, and also reverses some of the initial expansion in Social Security’s revenues. Elimination of the cap alters the pattern of redistribution implicit in Social Security, and also imposes larger distortions on labor supply and saving, which reduces overall welfare.
A preliminary study for the assessment of hypertension using static and dynamic IR thermograms
Authors: Thiruvengadam Jayanthi , Mariamichael Anburajan 
Published: July 2017

Abstract
Structural changes in blood vessels occur due to prolonged hypertension. Early detection of blood pressure (mm Hg) is essential for disease prevention. The aim of this work is to propose a computer-aided diagnostic (CADx) model for the diagnosis of hypertension using variables derived from non-contact static and dynamic thermal imaging in comparison with the pulse wave velocity (PWV)-derived parameters. Static and dynamic infrared (IR) thermograms of selected skin areas of the body from known hypertensive (n=14) and age- and sex-matched normal subjects were captured. The average skin surface temperature [SST (°C)] of selected skin areas of the body was calculated from a static IR thermogram. After denoising the dynamic IR thermogram using wavelets, the statistical variables power, mean, standard deviation (SD), variance, skewness and kurtosis were calculated. The variables derived from both static and dynamic thermograms were used to develop the CADx model. The performance of the CAD model was also tested by feature selection using principal component analysis (PCA). An accuracy of 75% (sensitivity=78.6%, specificity=71.4%) could be achieved with the average SST (°C) of the static IR thermogram alone. The statistical variables derived from the dynamic IR thermogram alone gave an accuracy of 82% (and 85% after feature selection by PCA), whereas the accuracy using standard methods like variables derived from PWV was only 71.4% (with and without feature selection). The highest accuracy of 89% could be achieved by combining variables like average SST (°C) measured from static and dynamic IR thermograms and PWV-derived variables.
Evanescent-Wave Reconstruction in Time Reversal System
Authors: Zang Rui , Wang Bing-Zhong , Ding Shuai , Gong Zhi-Shuang 
Published: July 2017

AbstractThe evanescent wave re-construction performance in the time reversal system with periodic sub-wavelength grating is studied in this paper. Both the analysis and calculation results show that the evanescent components of the initial wave can’t be re-constructed directly by far field time reversal processing. The results indicate the uncertainty of the super-resolution performance of the time reversal technique with randomly arranged scatters. A new method to achieve super-resolution imaging by using evanescent-to-propagation wave conversion also been proposed at the end of this paper.
A simple one-pot synthesis of 2,4-diaryl- 9H-pyrido[2,3-b]indoles under solvent-free conditions
Authors: Khoshneviszadeh Mehdi , Yahagh Aida , Soheilizad Mehdi , Mahdavi Mohammad 
Published: July 2017

Abstract
A novel, simple, one-pot synthesis of 2,4-diaryl-9H-pyrido[2,3-b]indoles is described. Heating a mixture of chalcone, oxindole and ammonium acetate in the presence of potassium tert-butoxide under solvent-free conditions afforded the title compounds in good to excellent yields.
Progress in understanding the molecular oxygen paradox – function of mitochondrial reactive oxygen species in cell signaling
Authors: Kuksal Nidhi , Chalker Julia , Mailloux Ryan J. 
Published: July 2017

AbstractThe molecular oxygen (O2) paradox was coined to describe its essential nature and toxicity. The latter characteristic of O2is associated with the formation of reactive oxygen species (ROS), which can damage structures vital for cellular function. Mammals are equipped with antioxidant systems to fend off the potentially damaging effects of ROS. However, under certain circumstances antioxidant systems can become overwhelmed leading to oxidative stress and damage. Over the past few decades, it has become evident that ROS, specifically H2O2, are integral signaling molecules complicating the previous logos that oxyradicals were unfortunate by-products of oxygen metabolism that indiscriminately damage cell structures. To avoid its potential toxicity whilst taking advantage of its signaling properties, it is vital for mitochondria to control ROS production and degradation. H2O2elimination pathways are well characterized in mitochondria. However, less is known about how H2O2production is controlled. The present review examines the importance of mitochondrial H2O2in controlling various cellular programs and emerging evidence for how production is regulated. Recently published studies showing how mitochondrial H2O2can be used as a secondary messenger will be discussed in detail. This will be followed with a description of how mitochondria use S-glutathionylation to control H2O2production.
Cancer and productivity loss in the Irish economy: an employer’s perspective
Authors: Hanly Paul , Pearce Alison , Sharp Linda 
Published: July 2017

Abstract
The extant literature suggests that cancer-related premature mortality costs have increased over time and are projected to increase further. Previous studies have generally employed a societal rather than an employer-based costing framework. A question therefore remains over the magnitude of productivity costs associated with premature death from cancer from an employer perspective. The objective of this study was to measure the productivity costs associated with cancer-related premature mortality in Ireland using the employer-focussed friction-cost approach (FCA). This entailed the application of an involuntary turnover costing framework rarely used in the management literature and represents the first estimate of its kind in Ireland. The all-cancer premature mortality cost was valued at €14.3 million in 2009. We modelled the sensitivity of our costs to changes in underlying labour market conditions and to ‘multiplier effects’ which represent recent advances in the FCA. We advocate that future studies should concentrate on combining elements of direct turnover cost according to accounting costing frameworks with the indirect costs measured by the FCA. Implications for current guidelines for the economic evaluation of health technologies in Ireland are also discussed.
Randomization Strategies Affect Motif Significance Analysis in TF-miRNA-Gene Regulatory Networks
Authors: Sadegh Sepideh , Nazarieh Maryam , Spaniol Christian , Helms Volkhard 
Published: July 2017

AbstractGene-regulatory networks are an abstract way of capturing the regulatory connectivity between transcription factors, microRNAs, and target genes in biological cells. Here, we address the problem of identifying enriched co-regulatory three-node motifs that are found significantly more often in real network than in randomized networks. First, we compare two randomization strategies, that either only conserve the degree distribution of the nodes’ in- and out-links, or that also conserve the degree distributions of different regulatory edge types. Then, we address the issue how convergence of randomization can be measured. We show that after at most 10 × |E| edge swappings, converged motif counts are obtained and the memory of initial edge identities is lost.
On Certain Topological Indices of Boron Triangular Nanotubes
Authors: Aslam Adnan , Ahmad Safyan , Gao Wei 
Published: July 2017

AbstractThe topological index gives information about the whole structure of a chemical graph, especially degree-based topological indices that are very useful. Boron triangular nanotubes are now replacing usual carbon nanotubes due to their excellent properties. We have computed general Randić (Rα), first Zagreb (M1) and second Zagreb (M2), atom-bond connectivity (ABC), and geometric–arithmetic (GA) indices of boron triangular nanotubes. Also, we have computed the fourth version of atom-bond connectivity (ABC4) and the fifth version of geometric–arithmetic (GA5) indices of boron triangular nanotubes.
Exploration of Characteristics Governing Dynamics of Whirlwinds: Application to Dust Devils
Authors: Pandey Sanjay Kumar , Maurya Jagdish Prasad 
Published: July 2017

Abstract
It is intended to model mathematically an ideal whirlwind which characterises this geo-physical phenomenon and eventually helps us decode the inherent dynamics. A dense cylindrical aerial mass is taken into consideration surrounding a rarer aerial region in order to keep a radial favourable gradient of pressure to sustain a rotational motion. It has been concluded that the whirlwind will survive as long as the low pressure region exists. The vertical pressure gradient also plays an equally important role. Since it is not connected to any cloud and the axial velocity is in the vertically upward direction, the momentary vertical gradient of pressure is required for its growth and survival. Horizontal ambient winds that rush towards low pressure zone, crush the air in the buffer zone, and turn vertically upward may also take the dust carried with them visibly to some height. It is considered that the angular azimuthal velocity varies within the annulus. An inference is that no whirlwind without a low pressure region within it can survive. This may be termed as the fundamental characteristic of whirlwind. It is further concluded that if the radial pressure difference between the outermost and innermost layers is larger, the whirlwind is thicker and consequently, it will last longer. Moreover, another conclusion arrived at is that the angular velocity will vanish if the inner radius is zero.
Zur Lehre Amunnachts: Ein Join und Missing Links
Authors: Dorn Andreas 
Published: July 2017

Summary
Between the years 1944 and 1954, the German Egyptological journal Zeitschrift für Ägyptische Sprache und Altertumskunde (ZÄS) stopped publication due to the Second World War and its repercussions. This paper presents a document written by Hermann Grapow in 1947 intended to help the publishing house J. C. Hinrichs obtain a licence from the authorities in the Soviet Occupation Zone, in order to publish the ZÄS anew. Here, emphasis will be placed upon the way in which Hermann Grapow argues in favour of the grant of the licence in his petition.
A Note on the Ancient Name of Dayr al-Barshā
Authors: Willems Harco 
Published: July 2017

SummaryThis article supplements a longer study published in ZÄS 132 (2005), pp. 173-189. It specifically addresses the place name Tjerty mentioned in the inscriptions accompanying the scene showing the colossal statue of the nomarch Djehutihotep, that exists in his tomb in Dayr al-Barshā. It is argued that the name al-îūd, used by the local population of Dayr al-Barshā for an open area in the south of the village, goes back to the ancient name Tjerty, adding an important argument in the discussion over the location of that settlement and the place where the Djehutihotep statue was erected.
Nourrir la machine humaine. Nutrition et alimentation au Québec, 1860-1945 par Caroline Durand
Authors: Boulianne Manon 
Published: July 2017

Durand, Caroline, 2015, Nourrir la machine humaine. Nutrition et alimentation au Québec, 1860-1945. Montréal & Kingston : McGill-Queen's University Press. Résumé rédigé par Manon Boulianne, Département d’anthropologie, Université Laval
Daniela Bleichmar, El imperio visible. Expediciones botánicas y cultura visual en la Ilustración hispánica (México: Fondo de Cultura Económica, 2016), 294 pp.
Authors: Mora Pacheco Katherinne Giselle 
Published: July 2017

La traducción al español de la obra Visible Empire, publicada originalmente en 2012 por la Universidad de Chicago, se presenta como una bella edición de tapa dura y numerosas ilustraciones a todo color. Sin embargo, no se trata de un libro de gran formato para ser admirado solo por su forma, sino que recoge los resultados de una investigación de casi una década, gran parte de la cual formó parte de la tesis que presentó la autora para obtener su doctorado en Historia por la Universidad de Princeton. Se trata de un abordaje interconectado y con énfasis en la producción gráfica de las reales expediciones botánicas a Chile y Perú, Nueva Granada y Nueva España y la expedición por territorios americanos y asiáticos del oficial naval Alejandro Malaspina. En la obra de Bleichmar la historia política y económica del imperio español está presente, pero sin ocupar el papel protagónico sino, más bien, en conjunción con elementos que aportan la historia de la ciencia y la historia del arte. Después de haber seleccionado unas 12.000 imágenes producidas en la segunda mitad del siglo XVIII (de las cuales esta edición incluye cerca de 80 ilustraciones), muchas de ellas por parte de los miembros de las expediciones botánicas en Chile y Perú, Nueva Granada y Nueva España y de la expedición Malaspina, la autora hace uso de las herramientas de la iconografía para analizar en detalle los contextos, objetivos y significados de las producciones gráficas. En el libro, las imágenes no son elementos decorativos ni sirven sólo para complementar explicaciones, sino que se involucran constantemente en las discusiones, en varios casos para más de un capítulo, por lo cual se echa de menos un índice o lista de figuras para que el lector pueda remitirse a los casos en mención.
La traducción del cuento policiaco en dos revistas colombianas de primera mitad del siglo XX: Chanchito (Bogotá, 1933-1934) y Crónica (Barranquilla, 1950-1951)
Authors: Agudelo Ana María , Guzmán Diana Paola 
Published: July 2017

La publicación de cuentos policiacos en dos revistas con públicos y prospectos diferentes como Crónica y Chanchito evidencia dinámicas de transferencia, reproducción y renovación del sistema literario en Colombia. La presencia de dicho género señala la existencia de un lector inclinado a la lectura por ocio y diversión. De igual forma, la traducción y el papel del traductor como agente cultural también se evidencian en la transformación que hace el propio traductor del contenido que traduce. Por otra parte, el artículo hace referencia a la renovación estética del repertorio que apareció en las publicaciones periódicas y al establecimiento de una interrelación entre culturas distantes.