bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signatures of breast cancer metastasis at a glance
Authors: Karagiannis George S. , Goswami Sumanta , Jones Joan G. , Oktay Maja H. , Condeelis John S. 
Published: April 2016

ABSTRACT
Gene expression profiling has yielded expression signatures from which prognostic tests can be derived to facilitate clinical decision making in breast cancer patients. Some of these signatures are based on profiling of whole tumor tissue (tissue signatures), which includes all tumor and stromal cells. Prognostic markers have also been derived from the profiling of metastasizing tumor cells, including circulating tumor cells (CTCs) and migratory–disseminating tumor cells within the primary tumor. The metastasis signatures based on CTCs and migratory–disseminating tumor cells have greater potential for unraveling cell biology insights and mechanistic underpinnings of tumor cell dissemination and metastasis. Of clinical interest is the promise that stratification of patients into high or low metastatic risk, as well as assessing the need for cytotoxic therapy, might be improved if prognostics derived from these two types of signatures are used in a combined way. The aim of this Cell Science at a Glance article and accompanying poster is to navigate through both types of signatures and their derived prognostics, as well as to highlight biological insights and clinical applications that could be derived from them, especially when they are used in combination.
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Authors: Kurkinen Kaisa M. A. , Marttinen Mikael , Turner Laura , Natunen Teemu , Mäkinen Petra , Haapalinna Fanni , Sarajärvi Timo , Gabbouj Sami , Kurki Mitja , Paananen Jussi , Koivisto Anne M. , Rauramaa Tuomas , Leinonen Ville , Tanila Heikki , Soininen Hilkka , Lucas Fiona R. , Haapasalo Annakaisa , Hiltunen Mikko 
Published: April 2016

ABSTRACT
Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here, we have elucidated whether downregulation of septin (SEPT) protein family members, which are implicated in synaptic plasticity and vesicular trafficking, affects APP processing and Aβ generation. SEPT8 was found to reduce soluble APPβ and Aβ levels in neuronal cells through a post-translational mechanism leading to decreased levels of BACE1 protein. In the human temporal cortex, we identified alterations in the expression of specific SEPT8 transcript variants in a manner that correlated with Alzheimer's-disease-related neurofibrillary pathology. These changes were associated with altered β-secretase activity. We also discovered that the overexpression of a specific Alzheimer's-disease-associated SEPT8 transcript variant increased the levels of BACE1 and Aβ peptides in neuronal cells. These changes were related to an increased half-life of BACE1 and the localization of BACE1 in recycling endosomes. These data suggest that SEPT8 modulates β-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1.
A New Framework and Prototype Solution for Clinical Decision Support and Research
in Genomics and Other Data-intensive Fields of Medicine
Authors: Evans James , Wilhelmsen Kirk , Berg Jonathan , Schmitt Charles , Krishnamurthy Ashok , Fecho Karamarie , Ahalt Stanley 
Published: April 2016

Introduction: In genomics and other fields, it is now possible to capture and
store large amounts of data in electronic medical records (EMRs). However, it is not
clear if the routine accumulation of massive amounts of (largely uninterpretable) data
will yield any health benefits to patients. Nevertheless, the use of large-scale medical
data is likely to grow. To meet emerging challenges and facilitate optimal use of
genomic data, our institution initiated a comprehensive planning process that addresses
the needs of all stakeholders (e.g., patients, families, healthcare providers,
researchers, technical staff, administrators). Our experience with this process and a
key genomics research project contributed to the proposed framework.Framework: We
propose a two-pronged Genomic Clinical Decision Support System (CDSS) that encompasses
the concept of the “Clinical Mendeliome” as a patient-centric list of genomic variants
that are clinically actionable and introduces the concept of the “Archival Value
Criterion” as a decision-making formalism that approximates the cost-effectiveness of
capturing, storing, and curating genome-scale sequencing data. We describe a prototype
Genomic CDSS that we developed as a first step toward implementation of the
framework.Conclusion: The proposed framework and prototype solution are designed to
address the perspectives of stakeholders, stimulate effective clinical use of genomic
data, drive genomic research, and meet current and future needs. The framework also can
be broadly applied to additional fields, including other ‘-omics’ fields. We advocate
for the creation of a Task Force on the Clinical Mendeliome, charged with defining
Clinical Mendeliomes and drafting clinical guidelines for their use.
Reviews Film
Authors: Bryant Meredith A. , Chase Robert J. , Getz Adam , O’steen Taylor K. 
Published: April 2016

Abstract
Instructions Not Included (2013) Mexico Director Eugenio Derbez Runtime 122 minutes Streaming USA, 2013 Distributed by Netflix
Calvary (2014) Ireland/UK Director John Michael McDonagh Runtime 100 minutes
The Dirties (2013) USA Director Matt Johnson Runtime 83 minutes
Mother (2009) Korea Director Joon-ho Bong Runtime 128 minutes
A Pessoa com Deficiência no Mercado de Trabalho e suas Implicações
Authors: Anjos Melissa Campello Guedes dos , Bezerra Schamkypou Bernardo , Farias Athena De Albuquerque , Marinho Gisanne De Oliveira , Barreto Julyanne De Oliveira Paes 
Published: April 2016

O estudo teve o bjetivo de analisar a inclusão da pessoa com deficiência no mercado trabalho. Para isso, utiliza como base, a lei 8.213/9;em que observa-se sua real aplicabilidade, como também seu alcance e efeitos, no que diz respeito à parcela de pessoas que se destina atender. Seu desenvolvimento se perfaz através do embasamento teórico, por meio de pesquisas bibliográficas; e prático, com aplicação de pesquisa de campo. Verifica-se, através de dados colhidos, que o referido diploma legal não atinge, de forma plena, os objetivos aos quais se destina. Seja em razão da discriminação presente na sociedade, da dificuldade de locomoção, da baixa escolaridade, ou até mesmo em relação à efetividade da Lei de Cotas. Busca-se, dessa maneira, um caminho para se chegar a um mercado de trabalho mais inclusivo e uma sociedade mais consciente e compreensiva, para lidar e conviver com as diferenças.
Pesquisa científica: conceitos básicos
Authors: Nunes Ginete Cavalcante , Nascimento Maria Cristina Delmondes , Alencar Maria Aparecida Carvalho de 
Published: April 2016

Em ciências, torna-se imprescindível que se encontre evidências que possam confirmar as hipóteses levantadas por uma situação de investigação. O presente estudo visa refletir a pesquisa científica, discutndo as proposições de alguns autores de acordo com os seus respectivos objetivos.
Observations on fertile populations of two Porella (Porellaceae, Marchantiophyta) species from Kumaun Region in the Western Himalaya, India
Authors: Rai Meena , Srivastava Prateek , Srivastava Surendra Nath 
Published: April 2016

The unrecorded androecia and feebly described gynoecia in Indian specimens of two Porella species, namely, P. densifolia subsp. appendiculata (Steph.) S. Hatt. and P. campylophylla var. ptychantha (Mitt.) F. Shaheen & S.C. Sriv., collected from Kumaun region in the state of Uttarakhand in Western Himalaya, are being described and compared besides observing variations in vegetative features of the plants.
Comparison of 2.4 and 5 GHz WLAN Network for Purpose of Indoor and Outdoor Location
Authors: Chruszczyk Łukasz , Zając Adam , Grzechca Damian 
Published: April 2016

Abstract
This paper presents comparison of prototype location system built with standard components of 2.4 and 5 GHz WLAN network infrastructure. The system can be used for personal or other objects’ positioning, both for indoor and outdoor environments. The system is local, i.e. its operational area is limited to WLAN network operating range. The system is based on standard and widely available WLAN components (access points, network adapters). The goal is to avoid any hardware and software modifications. Also position calculation should not be power hungry operation. Method of location is based in Received Signal Strength Indication (RSSI) returned by most of RF ICs (including WLAN). The main focus is research of how much accuracy (and usefulness) can be expected from standard WLAN hardware. Both static and dynamic scenarios have been tested and compared.
Abdominal Ultrasonography in Cattle
Authors: Munday K. , Mudron P. 
Published: April 2016

Abstract
The main goal of this study was to design and propose specific abdominal zones that would contain the gastrointestinal organs in healthy cattle when scanned with trans-abdominal ultrasound. The second goal was to measure the intestinal wall thicknesses of the cranial duodenum, jejunum and colon and to compare healthy cattle intestinal wall thicknesses with pathological cases. All of the six healthy cattle had organs located in the zones proposed. Three of the four pathological cases had organs outside of the zones proposed. The six healthy cattle had an average cranial duodenum wall thickness of 2.45 mm, an average jejunum wall thickness of 1.90 mm and an average colon wall thickness of 3.02 mm. Of the pathological cases, three out of four had intestinal walls that were thicker than that of the average values for the healthy cattle. The thickest intestinal walls were found in the paratuberculosis positive cow. This cow had a cranial duodenum wall thickness of 9.5 mm, a jejunum wall thickness of 4.9 mm and a colon wall thickness of 10.0 mm. In conclusion, trans-abdominal ultrasonography has the potential to be an ideal diagnostic tool for the investigation of the bovine gastrointestinal tract and gastrointestinal disorders such as abscesses, peritonitis and displacement of the abomasum. Trans-abdominal ultrasound also has the potential to be a non-painful, non-invasive tool for the diagnosis of proliferative intestinal inflammations in cattle.
Okun’s Law and Youth Unemployment in Germany and Poland
Authors: Dunsch Sophie 
Published: April 2016

Abstract
Unemployment rates, especially among youth, have increased in various countries of Europe over the last years. This paper examines changes in youth unemployment in Germany and Poland with Okun’s law, testing that young employees are more vulnerable to the business cycle. I estimate country specific Okun coefficients for five different age cohorts. The results show that youth in Poland is more sensitive to business cycle fluctuations than adults, while in Germany the difference between the age cohorts is not that distinctive. In addition, cohort differences in Germany are not statistically significant, while they are significant in Poland but only with regard to the two oldest age cohorts.
A further examination of the different labor market institutions affecting youth employment suggests long-term policy recommendations extending beyond GDP growth, such as structural reforms in education, as well as job-search assistance as short-term recommendation.
Socio-Economic Implications of Female Inclusion in Organizational Structures and in Leadership Positions
Authors: Krawiec Alexandra E. 
Published: April 2016

Abstract
The perception of women’s statutory place within organizations has been influenced by gender bias, which has led to discrimination. Lowering barriers related to gender inequality and introducing constructive changes takes a surprisingly long time. This procrastination can, to some extent, be attributed to the fear of potential economic costs, which is a misconception. A deeper understanding of the interplay between socio-economic factors and gender inequality within organizations can result in designing better, less biased, more merit-based structures and provide women with better career opportunities. Countries and organizations promoting gender equality practices prove that women’s inclusion in the labor market can be ‘cost-effective’ and beneficial in socio-economic terms.
This article analyzes selected determinants of female under representation in organizations, and in leadership positions in particular. The author points out to the rich body of research and to the multiple implications of gender inequality. Among the change resistant, deeply rooted factors, those originating in culture have a significant impact on women’s inclusion in organizations. This paper focuses on macro problems, and explains why some determinants are more persistent than others, and still influence gender equality at all levels of organizational structures. The determinants are systematized, analyzed using statistical data, and rooted in a wide body of research. The article also presents potential future developments and available tools that can be employed to speed up changes leading to gender equality in organizational structures, particularly in leadership positions.
A Nonlinear Model of Mix Coil Spring – Rubber for Vertical Suspension of Railway Vehicle
Authors: Dumitriu Mădălina 
Published: April 2016

Abstract
The paper focuses on a nonlinear model to represent the mechanical behaviour of a mix coil spring - rubber used in the secondary suspension of passenger rail vehicles. The principle of the model relies on overlapping of the forces corresponding to three components - the elastic component, the viscous component and the dry friction component. The model has two sources on non-linearity, in the elastic force and the friction force, respectively. The main attributes of the model are made visible by its response to an imposed displacement-type harmonic excitation. The results thus obtained from the applications of numerical simulation show a series of basic properties of the model, namely the dependence on amplitude and the excitation frequency of the model response, as well as of its stiffness and damping.
Optimized geometry, vibration (IR and Raman) spectra and nonlinear optical activity of p-nitroanilinium perchlorate molecule: A theoretical study
Authors: Tamer Ömer , Sefa Atalay Ahmet , Avci Davut , Atalay Yusuf , Tarcan Erdoğan , Marchewka Mariusz K. 
Published: April 2016

AbstractThe molecular modeling of p-nitroanilinium perchlorate molecule was carried out by using B3LYP and HSEH1PBE levels of density functional theory (DFT). The IR and Raman spectra were simulated and the assignments of vibrational modes were performed on the basis of relative contribution of various internal co-ordinates. NBO analysis was performed to demonstrate charge transfer, conjugative interactions and the formation of intramolecular hydrogen bonding interactions within PNAPC. Obtained large dipole moment values showed that PNAPC is a highly polarizable complex, and the charge transfer occurs within PNAPC. Hydrogen bonding and charge transfer interactions were also displayed by small HOMO-LUMO gap and molecular electrostatic potential (MEP) surface. The strong evidences that the material can be used as an efficient nonlinear optical (NLO) material of PNAPC were demonstrated by considerable polarizability and hyperpolarizability values obtained at DFT levels.
VO2(B) conversion to VO2(A) and VO2(M) and their oxidation resistance and optical switching properties
Authors: Zhang Yifu 
Published: April 2016

Abstract
Vanadium dioxide VO2 has been paid in recent years increasing attention because of its various applications, however, its oxidation resistance properties in air atmosphere have rarely been reported. Herein, VO2(B) nanobelts were transformed into VO2(A) and VO2(M) nanobelts by hydrothermal route and calcination treatment, respectively. Then, we comparatively studied the oxidation resistance properties of VO2(B), VO2(A) and VO2(M) nanobelts in air atmosphere by thermo-gravimetric analysis and differential thermal analysis (TGA/DTA). It was found that the nanobelts had good thermal stability and oxidation resistance below 341 °C, 408 °C and 465 °C in air, respectively, indicating that they were stable in air at room temperature. The fierce oxidation of the nanobelts occurred at 426, 507 and 645 °C, respectively. The results showed that the VO2(M) nanobelts had the best thermal stability and oxidation resistance among the others. Furthermore, the phase transition temperatures and optical switching properties of VO2(A) and VO2(M) were studied by differential scanning calorimetry (DSC) and variable temperature infrared spectra. It was found that the VO2(A) and VO2(M) nanobelts had outstanding thermochromic character and optical switching properties.
Toward biomaterial-based implantable photonic devices
Authors: Humar Matjaž , Kwok Sheldon J. J. , Choi Myunghwan , Yetisen Ali K. , Cho Sangyeon , Yun Seok-Hyun 
Published: April 2016

AbstractOptical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for usein vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.
Study of Seasonal Acoustic Properties of Sea Water in Selected Waters of the Southern Baltic
Authors: Grelowska Grażyna 
Published: April 2016

Abstract
Climate Research of the globe is a current task, in particular to confirm the general hypothesis of global warming associated with an increase in average temperature. The sea acoustic climate is derived from the concept of climate and refers to the conditions of propagation of acoustic waves in a particular basin. In this paper, the results of systematic measurements of temperature, salinity and velocity distributions of sound in the area of the southern Baltic will be present. The focus will be on the results of extensive measurements carried out „in situ” in particular.
Modified Isotropic Compression Relationship for Cement-Admixed Marine Clay at Low Confining Stress
Authors: Pan Y.-T. , Xiao H.-W. , Lee F.-H. , Phoon K.-K. 
Published: April 2016

Abstract
This technical note proposes a modified log-linear compression relationship for the pre-yield isotropic compression behavior of cement-admixed marine clay. The difference between this modified relationship and the conventional log-linear relationship is the use of the tensile strength as an added stress to the mean effective stress. This allows the cement-admixed clay to retain a finite specific volume as the mean effective stress approaches zero, which is more consistent with the fact that cement-admixed clays remain intact even under zero effective stress condition. Comparison with data from isotropic compression test shows that the addition of the tensile strength to the mean effective stress leads to a remarkable improvement in linearity, indicating a much-improved fit to the log-linear relationship. The resulting pre-yield compression index implies a non-zero equivalent effective bulk modulus, which is also intuitively more reasonable. At effective stress levels much lower than the tensile strength, the bulk modulus is approximately constant; this is also consistent with the notion of linear elastic behavior at low stress level.
CHETAH 10.0, the ASTM Computer Program for the Prevention of Reactive and Flammability Hazards
Authors: Harrison B. K. 
Published: April 2016

Abstract
The uses of the ASTM computer program CHETAH were described. The recently released version 10 is capable of accomplishing five different kinds of calculations related to chemical thermodynamics. The program enables the prediction of chemical reactive hazards, heats of reaction for combustion and other types of reactions, and a variety of flammability parameters. It can accomplish these calculations making use of its large internal databases of thermochemical properties or by making use of predictive methods for chemicals for which properties have yet to be determined.
Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment
Authors: Fréal Amélie , Fassier Coralie , Le Bras Barbara , Bullier Erika , De Gois Stéphanie , Hazan Jamilé , Hoogenraad Casper C. , Couraud François 
Published: April 2016

The axon initial segment (AIS) is required for generating action potentials and maintaining neuronal polarity. Significant progress has been made in deciphering the basic building blocks composing the AIS, but the underlying mechanisms required for AIS formation remains unclear. The scaffolding protein ankyrin-G is the master-organizer of the AIS. Microtubules and their interactors, particularly end-binding proteins (EBs), have emerged as potential key players in AIS formation. Here, we show that the longest isoform of ankyrin-G (480AnkG) selectively associates with EBs via its specific tail domain and that this interaction is crucial for AIS formation and neuronal polarity in cultured rodent hippocampal neurons. EBs are essential for 480AnkG localization and stabilization at the AIS, whereas 480AnkG is required for the specific accumulation of EBs in the proximal axon. Our findings thus provide a conceptual framework for understanding how the cooperative relationship between 480AnkG and EBs induces the assembly of microtubule-AIS structures in the proximal axon.SIGNIFICANCE STATEMENTNeuronal polarity is crucial for the proper function of neurons. The assembly of the axon initial segment (AIS), which is the hallmark of early neuronal polarization, relies on the longest 480 kDa ankyrin-G isoform. The microtubule cytoskeleton and its interacting proteins were suggested to be early key players in the process of AIS formation. In this study, we show that the crosstalk between 480 kDa ankyrin-G and the microtubule plus-end tracking proteins, EBs, at the proximal axon is decisive for AIS assembly and neuronal polarity. Our work thus provides insight into the functional mechanisms used by 480 kDa ankyrin-G to drive the AIS formation and thereby to establish neuronal polarity.