bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Systemic Sclerosis-associated Genes in a Turkish Population
Authors: Carmona F. David , Onat Ahmet Mesut , Fernández-Aranguren Tamara , Serrano-Fernández Alberto , Robledo Gema , Direskeneli Haner , Sawalha Amr H. , Yavuz Sule , Martín Javier 
Published: May 2016

Objective.To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population.Methods.There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631,STAT4-rs3821236,CD247-rs2056626,DNASE1L3-rs35677470,IL12A-rs77583790, andATG5-rs9373839). Association tests were conducted to identify possible associations.Results.Except forATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E–05, OR 1.76;CD247: p = 2.20E–03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21;IL12A: p = 0.079, OR 4.07;DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.Conclusion.The genetic component of SSc seems to be similar between Turks and Europeans.
Resident and Faculty Perceptions of Program Strengths and Opportunities for Improvement: Comparison of Site Visit Reports and ACGME Resident Survey Data in 5 Surgical Specialties
Authors: Caniano Donna A. , Yamazaki Kenji , Yaghmour Nicholas , Philibert Ingrid , Hamstra Stanley J. 
Published: May 2016

ABSTRACT

Resident and faculty views of program strengths and opportunities for improvement (OFIs) offer insight into how stakeholders assess key elements of the learning environment.Background

This study sought (1) to assess the degree to which residents and faculty in 359 programs in 5 surgical specialties (obstetrics and gynecology, orthopaedic surgery, otolaryngology, plastic surgery, and surgery) were aligned or divergent in their respective views of program strengths and OFIs; and (2) to evaluate whether responses to selected questions on the Accreditation Council for Graduate Medical Education (ACGME) Resident Survey correlated with strengths or OFIs identified by the residents during the site visit.Objective

Faculty and resident lists of program strengths and OFIs in site visit reports for 2012 and 2013 were aggregated, analyzed, and compared to responses on the Resident Survey.Methods

While there was considerable alignment in resident and faculty perceptions of program strengths and OFIs, some attributes were more important to one or the other group. Collegiality was valued highly by both stakeholder groups. Responses to 2 questions on the ACGME Resident Survey were associated with resident-identified OFIs in site visit reports pertaining to aspects of the didactic program and responsiveness to resident suggestions for improvement.Results

The findings offer program leadership additional insight into how 2 key stakeholder groups view elements of the learning environment as program strengths or OFIs and may serve as useful focal areas for ongoing improvement activities.Conclusions
VISIR-I: small vessels – least-time nautical routes using wave forecasts
Authors: Mannarini Gianandrea , Pinardi Nadia , Coppini Giovanni , Oddo Paolo , Iafrati Alessandro 
Published: May 2016

Abstract. A new numerical model for the on-demand computation of optimal ship routes based on sea-state forecasts has been developed. The model, named VISIR (discoVerIng Safe and effIcient Routes) is designed to support decision-makers when planning a marine voyage. The first version of the system, VISIR-I, considers medium and small motor vessels with lengths of up to a few tens of metres and a displacement hull. The model is comprised of three components: a route optimization algorithm, a mechanical model of the ship, and a processor of the environmental fields. The optimization algorithm is based on a graph-search method with time-dependent edge weights. The algorithm is also able to compute a voluntary ship speed reduction. The ship model accounts for calm water and added wave resistance by making use of just the principal particulars of the vessel as input parameters. It also checks the optimal route for parametric roll, pure loss of stability, and surfriding/broaching-to hazard conditions. The processor of the environmental fields employs significant wave height, wave spectrum peak period, and wave direction forecast fields as input. The topological issues of coastal navigation (islands, peninsulas, narrow passages) are addressed. Examples of VISIR-I routes in the Mediterranean Sea are provided. The optimal route may be longer in terms of miles sailed and yet it is faster and safer than the geodetic route between the same departure and arrival locations. Time savings up to 2.7 % and route lengthening up to 3.2 % are found for the case studies analysed. However, there is no upper bound for the magnitude of the changes of such route metrics, which especially in case of extreme sea states can be much greater. Route diversions result from the safety constraints and the fact that the algorithm takes into account the full temporal evolution and spatial variability of the environmental fields.
IFRS Adoption Impact On Financial And Accounting Information Quality: An Exploratory Study On Moroccan Petroleum And Gas Sector
Authors: Cherti Anass , Zaam Houria 
Published: May 2016

<p class="ber"><span lang="EN-US">The balance of <em>International Financial Reporting Standards</em> (IFRS), after ten years of their implementation, has reflected a positive perception of its impacts on the function “finance and accounting” of companies and issuers. Those companies and issuers observe, in a large majority that the transition to IFRS has increased the quality and the homogeneity of the information produced and the rapidity of their establishment. Unfortunately in academic research, such studies remains not clear as most publications front IFRS adoption impact in general manner which concern all sectors at the same study.</span></p><p class="ber"><span lang="EN-US">The purpose of this article is to present the results of an empirical study of three petroleum and gas companies listed in the <em>Casablanca Stock Exchanges</em> (CSE), to measure the impact of the IFRS adoption on financial and accounting information quality in Moroccan petroleum and gas sector.</span></p><p class="ber"><span lang="EN-GB">The released results show that this impact is positive for the petroleum and gas sector and the majority of the accounting and financial variables of this sector under IFRS dependents on those variables under the General Standardization Code of Morocco (GSCM). </span></p>
Impact of Low Mesopic Contrast Sensitivity Outcomes in Different Types of Modern Multifocal Intraocular Lenses
Authors: Plaza-Puche Ana B. , Alio Jorge L. , Sala Esperanza , Mojzis Peter 
Published: May 2016

Purpose To investigate the low mesopic contrast sensitivity function (LMCSF) of patients implanted with different modern optical bifocal and trifocal designs of multifocal intraocular lenses (mfIOLs). Methods This prospective, comparative, nonrandomized consecutive case series included 180 eyes that underwent cataract surgery. Six groups of eyes were differentiated: group A, eyes with the diffractive AT LISA tri 839MP; group B, eyes with diffractive FineVision; group C, eyes with the bifocal Lentis Mplus-LS313; group D, eyes with the diffractive bifocal Acri.Lisa 366D; group E, eyes with the diffractive apodized Acrysof ReSTOR SN6AD1; group F, as the control group, implanted with a monofocal spherical intraocular lens. The LMCSF was evaluated with the OPTEC® 6500 device at 3 months postoperatively using a luminance of 3 cd/m2. Results No significant differences among groups were detected in LMCSF for the spatial frequencies of 1.5, 3.0, 6.0, and 12.0 cpd (1.5 cpd: F = 1.81, p = 0.13; 3.0 cpd: F = 1.14, p = 0.14; 6.0 cpd: F = 1.87, p = 0.11; 12.0 cpd: F = 1.26, p = 0.29), but significant differences were found among groups for the spatial frequency of 18 cpd (F = 2.62, p = 0.03). When comparing the groups in pairs, only statistically significant differences were observed between groups E and F for the spatial frequency of 18.0 cpd (t = 3.27, p = 0.03) with better values for group F. Conclusion No significant differences were observed in LMCSF among the different mfIOLs studied. The third focus of trifocal IOL models did not adversely affect the LMCSF. The ReSTOR SN6AD1 showed the poorest LMCSF for the highest spatial frequency analyzed when compared with the control group.
A Comparison of Acetabular Impaction Grafting and Trabecular Metal for Revision Arthroplasty
Authors: Rowan Fiachra E. , Gorenchtein Mike , Aslam Shoaib , Condon Finbarr , Masterson Eric L. 
Published: May 2016

Background Acetabular defect reconstruction in revision hip arthroplasty may be achieved with acetabular impaction bone grafting (AIBG) or porous trabecular metal (TM) implantation. We sought to compare clinical and radiological outcomes of both methods at a single institution. Methods 36 patients that were revised using AIBG and 17 patients that were revised with TM were retrospectively reviewed from local joint registry data. 82% of the TM group and 64% of the AIBG group were ≥ Paprosky 2c. Rerevision was considered failure. Radiographs demonstrating 5 mm of migration of femoral head and 5° of acetabular component inclination change were considered loose. Results Age at surgery was earlier in the AIBG group (median 68 years vs. 74 years). Median follow-up was 5.9 years for AIBG and 5.4 years for TM. Harris Hip Scores improved significantly for both groups (mean improvement: 32 vs. 31). There were 4 failures (11%) in the AIBG group and none in the TM group. 3 of the 4 AIBG failures occurred following second-stage revision for prosthetic joint infection. 4 (11%) and 2 (12%) hip reconstructions demonstrated radiological evidence of loosening in AIBG and TM groups respectively. Conclusions AIBG and TM acetabular defect reconstructions achieve good clinical outcome but there is greater success with TM in higher grades of acetabular deficiency regardless of prior infection.
Three Radiation-Induced Metachronous Pelvic Tumors in a Patient who Underwent Radiotherapy for Cervical Cancer: A Case Report
Authors: Boban Marijo , Tomic Snjezana , Sulic Marija , Vrdoljak Eduard 
Published: May 2016

Introduction Patients treated with radiotherapy are under increased long-term risk of developing radiation-induced tumors. In this report we present an exceptionally rare case of a patient who, following radiotherapy for cervical cancer, developed 3 radiation-induced metachronous pelvic tumors. Case presentation In 1997, a 37-year-old patient with cervical adenocarcinoma (FIGO stage IB2) was subjected to adjuvant conventionally fractionated external-beam radiation therapy and brachytherapy following surgical treatment. Eleven, 14 and 15 years later, 3 radiation-induced malignant tumors developed: a leiomyosarcoma of the gluteus and 2 separate carcinomas of the rectum. Discussion and conclusion Radiotherapy for cervical carcinoma increases the standardized incidence ratios for rectal cancer and soft tissue sarcoma. Unfortunately, the current guidelines on contraindications to radiotherapy appear insufficient as they take into account a very limited number of clinical states and associated conditions, which is in disproportion to the rather high risk of radiation-induced malignancies of 0.45%. Information on the molecular characteristics of human radiation-induced tumors is still of no relevance for everyday clinical practice. Although radiotherapy is one of the most important modalities of oncological treatment, it should be judiciously used in cases where the benefits clearly outweigh the risk of serious untoward effects. In the case of patients undergoing pelvic irradiation, careful follow-up is needed for years.
Proficiency Testing for Quantification of Pesticide Residues in Treated Brown Rice Samples: Comparison of Performance of Japanese Official Multiresidue, Modified QuEChERS, and QuEChERS Methods
Authors: Otake Takamitsu , Yarita Takashi , Sakamoto Tomoko , Numata Masahiko , Takatsu Akiko 
Published: May 2016

Abstract
To support analytical skill development, testing of proficiency in pesticide residue analysis in brown rice was conducted for 86 participating Japanese laboratories. Brown rice test samples containing three target pesticides (etofenprox, fenitrothion, and thiamethoxam) were distributed to participants who were free to choose an appropriate analytical method. Reported results were evaluated using a z-score based on the consensus values calculated from the participant analytical results and a z-score based on the high-reliability reference values determined by the National Metrology Institute of Japan (NMIJ). It was found that 80–89 and 82–85% of participants achieved acceptable consensus-value-based and NMIJ-reference-value-based z-scores, respectively. More than 80% of participants reported results obtained using the Japanese official multiresidue method, solid-phase extraction technique with the Quick, Easy, Cheap, Effective, Rugged, and Safe (modified QuEChERS) method or QuEChERS method. We show that the concentrations determined by the NMIJ using these three methods combined with isotope-dilution MS having high reliability agreed well and that the method performances were comparable.
Tensions Between Teaching Sexuality Education and Neoliberal Policy Reform in Quebec’s Professional Competencies for Beginning Teachers
Authors: Parker Dan , McGray Robert 
Published: May 2016

This research draws into question the effects that neoliberal policy reforms — with an emphasis on individual and measurable “competencies” — has on new teachers teaching sexuality education in Quebec. While we examine professional competencies that teachers can use to define their mandate for teaching sexuality education as a beginning professional, we also detail the ways in which the competencies constrain pedagogical practice. Our argument is that while there are avenues for teachers to use the professional competencies for sexuality education, neoliberal reforms atomize teachers in a search for accountability. As a result, for fear of generating controversy, potentially contentious issues like sexuality education are not readily addressed. This atomization restricts both teachers and the field — the policy circumscribes sexuality education as personal rather than cultural. As such, we are left impotent to address cultural issues of sexuality education.
L’incidence de l’âge et de la vulnérabilité de la victime sur l’évaluation de sa part de responsabilité dans le préjudice subi : l’exemple des services financiers
Authors: Duclos Cinthia , Levesque Frédéric 
Published: May 2016

Dans le cadre de ce numéro thématique de la Revue générale de droit portant sur la protection juridique des aînés, une professeure de droit des services financiers et un professeur de responsabilité civile ont décidé de collaborer pour étudier certains aspects de cette protection qui se trouvent à la jonction de leurs domaines respectifs. Plus particulièrement, les chercheurs portent leur réflexion sur l’incidence de l’âge et de la vulnérabilité de la victime sur l’évaluation de sa part de responsabilité dans le préjudice subi, dans le contexte d’un recours en responsabilité civile contre un prestataire de services financiers. La notion de « part de responsabilité » renvoie aux concepts de faute de la victime, de l’acceptation des risques, de la limitation du préjudice, de la rupture du lien de causalité (novus actus interveniens) et de la ratification par le client des actes posés par le prestataire de services financiers. À la lumière de plusieurs exemples jurisprudentiels, les auteurs cherchent à déterminer si l’âge et la vulnérabilité de la victime incitent les tribunaux à adopter une attitude plus protectrice envers cette dernière, dans ce contexte. Par attitude protectrice des tribunaux, les auteurs entendent le fait que ces derniers excusent le comportement parfois fautif de la victime et lui octroient une indemnisation sans retenir contre elle sa part responsabilité, le cas échéant, dans le préjudice subi.
Les baux en résidences pour personnes âgées : quelle effectivité pour la protection des droits ?
Authors: Grégoire Marie Annik 
Published: May 2016

Les droits des personnes âgées vivant en résidences privées sont-ils bien protégés ? Telle est la question à laquelle tentait de répondre une étude publiée en 2011. Or, depuis, plusieurs modifications législatives sont intervenues afin de tenter de protéger plus adéquatement cette clientèle vulnérable. La présente analyse vise à vérifier, à l’aide d’exemples concrets tirés des baux obtenus dans le cadre de l’étude de 2011, si les changements proposés pourront véritablement permettre de régler les problèmes de protection des droits des personnes âgées vivant en résidences privées. Devant le constat que les modifications législatives et réglementaires n’auront probablement qu’un effet fort limité, une solution plus adaptée sera proposée afin de veiller à assurer aux personnes âgées vivant en résidence privée une véritable protection sociale de leurs droits.
Les obligations de la banque au regard des sommes déposées dans un compte en fidéicommis
Authors: Lacoursière Marc 
Published: May 2016

Le compte bancaire est l’outil privilégié pour effectuer la plupart des opérations financières, puisque les ordres de paiement doivent y transiter. En certaines circonstances, le bénéficiaire d’une transaction mandate une tierce personne, appelée fidéicommissaire ou fiduciaire, pour agir en son nom. Tel est le cas lorsqu’une personne âgée mandate un courtier en placement pour effectuer des transactions ou lorsqu’un client verse des avances à un avocat ou à un notaire. La relation juridique devient alors triangulaire et comprend les intervenants suivants : la banque (détentrice du compte), le mandataire (fidéicommissaire ou fiduciaire, selon le cas) et le bénéficiaire. Comme l’a illustré la célèbre affaire Earl Jones, il peut arriver que le mandataire agisse dans son intérêt personnel au détriment des intérêts du bénéficiaire. Puisque le recours d’un bénéficiaire à l’encontre de ce mandataire fautif peut s’avérer infructueux (insolvabilité ou faillite), la banque devient alors la cible de choix du bénéficiaire lésé. Cette présentation aura pour but d’analyser les droits et les obligations de la banque en de telles circonstances. En nous inspirant de l’obligation de signalement des transactions contrevenant aux lois canadiennes sur le blanchiment de capitaux, nous suggérons d’entamer une réflexion sur l’imposition d’une obligation similaire aux institutions financières dans le cadre des transactions préjudiciables effectuées par un mandataire, lorsque les victimes sont des personnes âgées.
Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults
Authors: Dieye Yakhya , Mbengue Babacar , Dagamajalu Shobha , Fall Mouhamadou Mansour , Loke Mun Fai , Nguer Cheikh Momar , Thiam Alassane , Vadivelu Jamuna , Dieye Alioune 
Published: May 2016

Background.With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoanPlasmodiumcause malaria. However, almost all the fatalities are due toPlasmodium falciparum, a species responsible for the severest cases including cerebral malaria. Immune response toPlasmodiumfalciparum infection is mediated by the production of pro-inflammatory cytokines, chemokines and growth factors whose actions are crucial for the control of the parasites. Following this response, the induction of anti-inflammatory immune mediators downregulates the inflammation thus preventing its adverse effects such as damages to various organs and death.Methods.We performed a retrospective, nonprobability sampling study using clinical data and sera samples from patients, mainly adults, suffering of non-cerebral or cerebral malaria in Dakar, Sénégal. Healthy individuals residing in the same area were included as controls. We measured the serum levels of 29 biomarkers including growth factors, chemokines, inflammatory and anti-inflammatory cytokines.Results.We found an induction of both pro- and anti-inflammatory immune mediators during malaria. The levels of pro-inflammatory biomarkers were higher in the cerebral malaria than in the non-cerebral malaria patients. In contrast, the concentrations of anti-inflammatory cytokines were comparable in these two groups or lower in CM patients. Additionally, four pro-inflammatory biomarkers were significantly increased in the deceased of cerebral malaria compared to the survivors. Regarding organ damage, kidney failure was significantly associated with death in adults suffering of cerebral malaria.Conclusions.Our results suggest that a poorly controlled inflammatory response determines a bad outcome in African adults suffering of cerebral malaria.
Autoria docente em sala de aula: uma análise de situações de trabalho a partir de relatos de prática
Authors: Luna Tatiana 
Published: May 2016

O trabalho docente raramente é concebido como uma atividade profissional (FAITA, 2005), seja pelas pesquisas acadêmicas que o associam apenas à esfera educacional, seja pelo senso comum que o identifica como um tipo de “sacerdócio”. Contrapondo-se a esses discursos, este estudo considera a atividade do professor enquanto tal e se ocupa especificamente da prática de ensino-aprendizagem de língua materna, observando-a como uma das ramificações do campo de trabalho pedagógico. Apoiando-nos nos estudos acerca da análise da linguagem em situações de trabalho (TELLES, ALVAREZ, 2004; SOUZA-E-SILVA, 2004; FAITA, 2005), bem como em estudos acerca do letramento em ambientes escolares (KLEIMAN, 2007; SIGNORINI, 2007), nosso objetivo é observar como, no âmbito da sala de aula, se estabelecem as inter-relações entre as normas antecedentes e as renormalizações. Em outras palavras, como os professores reconstroem as normas prescritas pelas instituições (por exemplo, o projeto político-pedagógico da escola, as orientações curriculares formulados pelo Ministério da Educação e por secretariais estaduais e municipais e o próprio livro didático) ao organizarem suas sequências didáticas. Para tal, analisamos sete relatos de experiência de professores vencedores do “Programa Olimpíada de Língua Portuguesa Escrevendo o Futuro” em 2012 na categoria crônica. Nesse contexto, entendemos que as prescrições correspondem ao regulamento da Olimpíada, ao material didático dedicado ao gênero crônica - caderno “A ocasião faz o escritor”, CD-ROOM e coletânea de textos - e às orientações para a escrita dos relatos. Os resultados indicam que os docentes ressignificam o ensino de gêneros e modificam a organização em sequências didáticas prevista pelo material da Olimpíada. As atividades relatadas favorecem mais a inserção dos alunos nas práticas de letramento do que a apropriação do modelo didático da crônica. Também constatamos que alguns textos subvertem as coerções próprias do gênero relato de experiência e as normas postuladas pelo programa para a escrita desse relato.