bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rtt101‐Mms1‐Mms22 coordinates replication‐coupled sister chromatid cohesion and nucleosome assembly
Authors: Zhang Jingjing , Shi Di , Li Xiaoli , Ding Lin , Tang Jun , Liu Cong , Shirahige Katsuhiko , Cao Qinhong , Lou Huiqiang 
Published: June 2017

AbstractTwo sister chromatids must be held together by a cohesion process from their synthesis during S phase to segregation in anaphase. Despite its pivotal role in accurate chromosome segregation, how cohesion is established remains elusive. Here, we demonstrate that yeast Rtt101‐Mms1, Cul4 family E3 ubiquitin ligases are stronger dosage suppressors of loss‐of‐function eco1 mutants than PCNA. The essential cohesion reaction, Eco1‐catalyzed Smc3 acetylation is reduced in the absence of Rtt101‐Mms1. One of the adaptor subunits, Mms22, associates directly with Eco1. Point mutations (L61D/G63D) in Eco1 that abolish the interaction with Mms22 impair Smc3 acetylation. Importantly, an eco1LGpol30A251V double mutant displays additive Smc3ac reduction. Moreover, Smc3 acetylation and cohesion defects also occur in the mutants of other replication‐coupled nucleosome assembly (RCNA) factors upstream or downstream of Rtt101‐Mms1, indicating unanticipated cross talk between histone modifications and cohesin acetylation. These data suggest that fork‐associated Cul4‐Ddb1 E3s, together with PCNA, coordinate chromatin reassembly and cohesion establishment on the newly replicated sister chromatids, which are crucial for maintaining genome and chromosome stability.
Hormone replacement treatment choices in complete androgen insensitivity syndrome: an audit of an adult clinic
Authors: Ko Jennifer K Y , King Thomas F J , Williams Louise , Creighton Sarah M , Conway Gerard S 
Published: June 2017

Objective
To review the treatment choices of women with complete androgen insensitivity syndrome (CAIS) at a single tertiary centre.

Design
Retrospective review.

Patients
Women with CAIS identified from our database.

Results
The study group comprised 141 women with CAIS. Eleven percent (16/141) of women had gonads in situ, 3 of whom were under workup for gonadectomy. The age of gonadectomy in the remainder 125 women was 17 (0.1–53) years. The most common form of HRT was oral oestrogen or transdermal oestrogen in 80% (113/141). 13/141 (9%) women used vaginal oestrogens alone or together with other forms of HRT. Testosterone preparations had been used by 17% (24/141) of women and were currently used in 10% (14/141). Of those who had used testosterone, 42% (10/24) had chosen not to continue after a therapeutic trial.

Conclusions
In a clinic offering individualised multidisciplinary care for women with CAIS, we found that the majority of women chose oestrogen-based treatment while a significant minority used testosterone.
Continuity of Care in Infancy and Early Childhood Health Outcomes
Authors: Enlow Elizabeth , Passarella Molly , Lorch Scott A. 
Published: June 2017

BACKGROUND AND OBJECTIVES:Continuity of care is a key aspect of the patient-centered medical home and improves pediatric outcomes. Health care reform requires high-quality data to demonstrate its continued value. We hypothesized that increased provider continuity in infancy will reduce urgent health care use and increase receipt of preventive services in early childhood.METHODS:Continuity, using the Usual Provider of Care measure, was calculated across all primary care encounters during the first year of life in a prospectively-constructed cohort of 17 773 infants receiving primary care from birth through 3 years at 30 clinics. Health care utilization and preventive care outcomes were measured from ages 1 to 3 years. Confounders, including chronic conditions, number of sick visits in the first year, socioeconomic status, and site, were addressed by using multivariable regression models incorporating a propensity score.RESULTS:Demographics associated with the lowest continuity quartile included white race (adjusted odds ratio [aOR] 1.43; 95% confidence interval [CI] 1.25–1.64), Medicaid insurance (aOR 1.41; 95% CI 1.23–1.61), and asthma (aOR 1.59; 95% CI 1.30–1.93). Lower continuity was associated with more ambulatory care-sensitive hospitalizations (adjusted incidence rate ratio 2.74; 95% CI 1.49–5.03), ambulatory sick visits (adjusted incidence rate ratio 1.08; 95% CI 1.05–1.11), and lower odds of lead screening (aOR 0.61; 95% CI 0.46–0.79). These associations were stronger for children with chronic conditions. Continuity measured during well visits was not associated with outcomes.CONCLUSIONS:Continuity may improve care quality and prevent high-cost health encounters, especially for children with chronic conditions. Novel solutions are needed to improve continuity in the medical home.
A EXPERIÊNCIA DA PESQUISA NA FORMAÇÃO DOCENTE: unindo teoria à prática
Authors: Ferreira Ilane Cavalcante , Henrique Ana Lúcia Sarmento 
Published: June 2017

Este texto tem como objetivo discutir a pesquisa como princípio educativo na perspectiva da formação continuada do docente, a partir da experiência vivenciada na disciplina Formação de Professores para Educação Profissional, referenciada nas discussões de Demo (2000) e Echeverría (2002) sobre a pesquisa como processo formativo; de Tardif (2002) e Candau (sd) sobre a formação docente; e de Machado (2008), Araujo (2008), Moura (2006) e Souza (2013) sobre a formação docente para a Educação Profissional e Tecnológica (EPT). Tentando unir teoria à prática, objetivou-se, na disciplina, a integração do conteúdo a ser ministrado em sala de aula com a experiência mesma do fazer científico na perspectiva de que o trabalho final da disciplina se revestisse de um caráter científico-reflexivo, ao mesmo tempo, inovador e que levasse também à produção de conhecimento na área. A pesquisa se desenvolveu em três campi do IFRN investigando três categorias gerais: identidade docente, prática pedagógica e percepção sobre EP. Para a coleta de dados utilizamos a entrevista semiestruturada gravada, cujas transcrições foram socializadas entre os alunos para que cada grupo pudesse analisar a categoria a qual havia escolhido. Como resultado da pesquisa, tivemos a produção de quatro artigos por parte dos alunos, versando sobre as diferentes categorias analisadas.
El sector de los alimentos ecológicos: Regulación y etiquetado ecológico = The organic food sector: Regulation and ecological labeling
Authors: Aguirre García María Belén 
Published: June 2017

<p>El sector de los alimentos ecológicos y la evolución de su normativa están experimentando continuos cambios y ampliaciones acordes con los flujos económicos y comerciales de nuestros días. El objetivo del artículo, desde una metodología descriptiva, es reflejar esta evolución, presentando la regulación vigente, que es exhaustiva y abarca ámbitos diversos: sistemas de producción agraria ecológica, control y certificación de operadores, comercialización y etiquetado de los alimentos ecológicos. Asimismo, se abordan las diferentes caracterizaciones en la actualidad del etiquetado de los alimentos ecológicos en Europa, en España y en las Comunidades Autónomas.</p><p> </p><p>The organic food sector and the evolution of its regulations are undergoing continuous changes and extensions in line with the economic and commercial flows of our day. The objective of the article, from a descriptive methodology, is to reflect this evolution, presenting the current regulation, which is exhaustive and covers different areas: ecological agricultural production systems, operator control and certification, marketing and labeling of organic food. It also addresses the different characterizations of organic food labeling in Europe, Spain and the “Comunidades Autónomas”.</p><p> </p>
Mini Special Issue on Design and Manufacturing for Environmental Sustainability
Authors: Umeda Yasushi ,   Professor, Graduate School of Engineering, The University of Tokyo
Published: June 2017

As the third special issue on Design and Manufacturing for Environmental Sustainability for IJAT, this issue focuses on design and manufacturing theories and methodologies for achieving environmental sustainability and the topic of the special issue seems to be becoming established in this journal.
This special issue contains six articles consisting of a wide variety of rather novel topics emerging in the domain of design and manufacturing for environmental sustainability. The first three deal with design problem in the broader sense: designing of system of systems taking distributed energy generation systems, upgradable design problems, and selection problem of end-of-life products recovery options integrated from the view of environmental load and cost. The last three papers deal with manufacturing problems in the broader sense – motion extraction problems for disassembly automation, machine tool energy efficiency, and optimization problems related to machine tool operating conditions for increasing environmental sustainability. Some papers, revised and extended at the editor’s request, were presented originally at EcoDesign 2015, the ninth international symposium on environmentally conscious design and inverse manufacturing, held in Tokyo, Japan, 2015.
The editor thanks the authors and reviewers for their comprehensive efforts in making this special issue possible and hopes these articles will encourage further research on design and manufacturing for environmental sustainability.
Comparing Nondestructive Sampling Techniques for Predicting Forage Mass in Alfalfa–Tall Wheatgrass Pasture
Authors: Baxter Lisa L. , West Charles P. , Brown C. Philip , Green Paul E. 
Published: June 2017

Core Ideas
To compare five nondestructive sampling techniques for predicting forage mass.
Procedures: pasture ruler, rising plate meter, ImageJ, PowerPoint photo point count, and normalized difference vegetation index.
PowerPoint model was the best option if restricted to one sampling procedure.
Combined (Height + ImageJ) model was the best option for predicting forage mass.
These measurements require simple equipment, are adaptable, and can be automated.
Producers rely on subjective visual assessments to estimate forage mass in their pastures, which often are inaccurate and lead to poor stocking decisions. The objective of this trial was to compare five nondestructive sampling techniques for predicting forage mass in three alfalfa–tall wheatgrass [Medicago sativa L.; Thinopyrum ponticum (Host) Beauv.] pastures in the southern High Plains. Procedures included canopy height measured with a pasture ruler and rising plate meter (RPM), percentage of green pixels from ImageJ analyses, percentage of green points from photo point count in PowerPoint, and normalized difference vegetation index (NDVI). Height and RPM were linearly regressed on measured forage mass while the remaining were linearly regressed on the natural log of measured forage mass. Considering their limitations, stepwise regression was used to find the best combination of digital and physical procedure (Height + ImageJ) that reduced model error. Calibration models were then applied to external data to determine predictive ability of each procedure. The PowerPoint model was the best, most precise option if restricted to a single sampling procedure, whereas the combined model possessed the superior combination of high R2 and low model error. The combined and PowerPoint models possessed the highest R2pred, but the combined model would be more applicable since it did not saturate when measured forage mass exceeded 1200 kg DM ha−1. The use of ImageJ with canopy height measurements for forage mass prediction requires simple equipment, lends itself to automation, and is adaptable to various forage systems.
Reseña: Historias de empresarias innovadoras en Colombia
Authors: Godoy Estrella Enit 
Published: June 2017

Este libro es el resultado de un proyecto de investigación financiado por Colciencias, que fue realizado por docentes investigadores del grupo de Estudios Contemporáneos en Contabilidad, Gestión y Organizaciones, de la Facultad de Ciencias Económicas de la Universidad Militar Nueva Granada. El resultado del estudio se manifiesta en dieciséis historias tomadas de una muestra poblacional de 60 empresarias, de seis ciudades principales de Colombia: Bogotá, Barranquilla, Bucaramanga, Cali, Medellín y Armenia. Aquí los autores resaltan el papel de las mujeres en la sociedad, y cómo contribuyen en la economía y la innovación; ellas, a pesar de ser esposas y madres, deben ser polifacéticas si entran en el mundo del emprendimiento.
Competition, Imitation, and R&D Productivity in a Growth Model with Industry-Specific Patent Protection
Authors: Mosel Malte 
Published: June 2017

Abstract
Recent empirical studies suggest a need for a flexible patent regime responding to industry differences. In practice, industry-specific modifications of patent length already exist but lack theoretical foundation. This paper intends to make up for this neglect by scrutinizing in what direction industry characteristics influence optimal patent length. It is found that patents ought to be shorter, the more intense competition, the higher R&D productivity, and the more intricate reverse engineering in an industry are. Unlike similar Schumpeterian growth models, this model assumes Cournot competition and introduces an empirically substantiated measure of industry differences in the ability to catch up with a technological leader. It is found that for most empirically plausible cases the familiar inverted-U relation between patent length and growth carries over to the Cournot set-up.
The Law and Economics of Enhancing Cartel Enforcement: Using Information From Non-Cartel Investigations to Prosecute Cartels
Authors: Ghosal Vivek 
Published: June 2017

Abstract
I present the following proposal: information revealed during non-cartel investigations by competition law enforcement authorities, such as evaluation of mergers and acquisitions (M&As) or investigation of monopolization (dominance) conduct, should be directly used to investigate and prosecute cartels. Currently, in several jurisdictions, information acquired in, for example, an M&As investigation typically cannot be directly used for a cartel case due to the underlying statutes and the legal and administrative procedures that govern information use. Reviewing the management and corporate strategy literature, I note that M&As form a vital part of firms’ core business strategy, with the longer-run strategic aspects being more important. These longer-run strategies could be jeopardized if the firms were engaging in collusion, as the likelihood of detection and prosecution would increase under the proposed rule change, which would punish bad (collusive) behavior. I argue that irrespective of exactly how many cartels are actually prosecuted via this channel, the proposal has the likelihood of creating a meaningful deterrent effect. I also discuss the potential downsides related to Type 1 errors and administrative costs. Overall, I argue that the proposed rule change could increase the efficiency and effectiveness of cartel enforcement, and open an additional front in the fight against hardcore cartels that operate within jurisdictions as well as internationally.
Caracterización de Adultos Mayores Suicidas del Área Metropolitana de Risaralda, Años 2005-2011
Authors: Rodríguez Escobar José Adalberto , Calderón Restrepo Maria Fernanda , Bocanegra Díaz Katherine , Gallego García Valentina 
Published: June 2017

<p align="left">El objetivo de la presente investigación, fue caracterizar los adultos mayores suicidas del área metropolitana de Risaralda entre 2005-2011. Para ello, se realizó un estudio cuantitativo – descriptivo y transversal, recurriendo a las bases de datos del Instituto Nacional de Medicina Legal y Ciencias Forenses, seccional Risaralda. En el periodo estudiado se presentaron 41 casos (95% hombres y 5% mujeres), de los cuales Pereira aportó el 73.1% de los casos. De estos, el 46.4% recurrió al ahorcamiento y 26.9% al arma de fuego. Otros datos indican que el 78.1% de los decesos ocurrió en la vivienda y que la escolaridad es de un 43.8% para quienes realizaron estudios primarios y el 7.3% estudios secundarios. Por otra parte, marzo fue el mes predominante con el 19.5%, seguido de septiembre con 17.1%. Del total, prevalecieron los casados aportando el 36.6% de los casos. La tasa para los 6 años se ubicó en 7.99 x 100.000; 17.47 en hombres y 0.7 en mujeres. La tasa masculina fue directamente proporcional al grupo de edad: 20.27 para el rango de 60-69; 21.21 para 70-79, y 26.06 en el grupo de 80-89 años. Esto deja entrever el riesgo, se infiere que a mayor edad mayor probabilidad de suicidio. Dichas cifras ameritan la realización urgente de programas de prevención para la mitigación de factores de riesgo.</p>
Del sujeto, la subjetividad y la subjetivación a la noción de la responsabilidad subjetiva en el conflicto armado en Colombia
Authors: Caro Perdomo Juliana Patricia , Herrera Contreras José Alexander , Wilches Luis Eduardo , Gómez Edwin Arsecio , Jiménez Carmen , Álvarez Martha 
Published: June 2017

<p>Este artículo comparte el diálogo interdisciplinar (sociología-antropología-filosofía-psicología social) del grupo Cuchavira de la UNAD, en torno al proceso de investigación creativo-hermenéutico, realizado con estudiantes de esta universidad que se encuentran en situación de reinserción-desmovilización, del conflicto armado colombiano. El equipo define un instrumento teórico de análisis-síntesis para abordar su investigación7y, a partir de los conceptos de <em>sujeto</em>, <em>subjetividad </em>y <em>subjetivación </em>en perspectiva histórico-teórica, se propone como categoría de análisis comprensiva <em>el sujeto de la responsabilidad</em>. La <em>responsabilidad </em>frente a la <em>decisión </em>de participar en el conflicto se lee como una “evasión” de los combatientes, quienes se amparan en la idea de obediencia ciega, la cual sustrae la subjetivación de los excesos producidos por el conflicto bélico. Las consecuencias más conocidas son los reiterados fracasos de los procesos de paz, desmovilización y reinserción, basados en la lógica de victimización de la memoria, culpabilidad del otro, exclusión de las intencionalidades y la interpelación de la r<em>esponsabilidad </em><em>subjetiva</em>. De allí la importancia de visibilizar la condición del <em>sujeto de la decisión </em>con una resignificación subjetivo-colectiva en medio del conflicto.</p>
Editorial
Authors: Quitián David 
Published: June 2017

<p>No podía ser más afortunado este volumen: su tema siempre carga consigo entusiasmo desbordado, a propósito del nombre de nuestra revista. <em>Desbordes </em>de cancha, regates de académicos que juegan su partido provistos del talento hermenéutico, son los que presentamos en este número, que da el pitazo inicial para las siguientes convocatorias que serán –así como esta es del Mundial Brasil 2014- de temas específicos en un intento de, usando lenguaje balompédico, “centrar al área buscando el cabezazo” de investigadores y estudiosos de aspectos de coyuntura como la guerra y la paz (tema del siguiente volumen) o de las ciencias sociales y el país que será el asunto central del volumen convocado para el 2016.</p>
Fútbol y política en Colombia: reflexiones politológicas en un año mundialista
Authors: Dávila Ladrón de Guevara Andrés 
Published: June 2017

<p>El año 2014 será recordado como uno de los más especiales, satisfactorios y emocionantes en la historia del fútbol colombiano. La razón, sobra decirlo, es el meritorio desempeño del leccionado nacional de hombres en categoría mayores en la Copa Mundial de Brasil. Este artículo podría, si así lo quisiera, constituirse en un recuento detallado de cómo se logró tal desempeño en lo futbolístico, haciendo énfasis en el equipo, la táctica, el cuerpo técnico, las individualidades. No obstante, y a la manera de un tejido que se nutre de distintos hilos, se desarrolla a partir de varias tesis o enunciados sobre lo sucedido y sus implicaciones sociales y políticas.</p>
Estadio de excepción”: reflexiones sobre el Estado de Excepción a propósito de los mundiales de fútbol profesional
Authors: Cuevas Bascuñán Ricardo 
Published: June 2017

<p>El pasado Mundial de Fútbol organizado por la FIFA en Brasil dejó en evidencia no solo en lo que se ha transformado el deporte hoy en día, sino también, el tipo de sociedad en la cual vivimos y sus correspondientes Estados, es decir, una sociedad de control amparada en un Estado de Excepción constante. Un ejemplo particular resalta esta tesis: el caso de los aficionados chilenos, quienes ingresaron sin boletos y por el sector de prensa al Estadio Maracaná, quienes posteriormente fueron expulsados del país. A este caso es posible sumar un antecedente de similares características en cuanto a la solución adoptada: cuando barrabravas argentinos fueron expulsados de Sudáfrica en el Mundial de Fútbol FIFA de dicho país. Sin embargo, los casos de Brasil y Sudáfrica no son aislados, ni siquiera unas instancias limítrofes relativas a este magno-evento, sino más bien la generalidad dentro de un espectáculo cada vez más intervenido, tanto por el Estado como por los organismos de seguridad (pública y privada).</p><p> </p>
EL DESARROLLO HUMANO COMO EJE DE REFLEXIÓN EN EL PROGRAMA DE PSICOLOGIA EN LA UNAD
Authors: Perdomo María Norvy , Jiménez Ricardo 
Published: June 2017

<p>Este documento presenta los elementos clave del concepto del desarrollo humano en la construcción del ser, el sujeto social y lo social comunitario, con el fin de que favorezca los procesos de formación, investigación y proyección social del programa de Psicología de la UNAD, cuya base se encuentra soportada en los criterios de actuación del Proyecto Académico Pedagógico Solidario - PAPS.</p><p>En su construcción se tuvo en cuenta a autores como Ballesteros B., Bruner, Chanquía, entre otros, con el fin de dar una mirada multidisciplinar al concepto de Desarrollo Humano, y así proponer alternativas para mejorar la calidad de vida y bienestar de las personas. En este proceso, el psicólogo unadista, sea un facilitador para las comunidades en el reconocimiento de los procesos complejos que encierra la relación de las personas y grupos con sus respectivos contextos sociales, y coadyuvando como actor social, en la dinamización de condiciones que centran su hacer en la pregunta por el ser humano y su relación con el entorno, desde una dimensión cultural, histórica y política.</p><p>El artículo concluye con una reflexión que permite reconocer la importancia y la necesidad del fortalecimiento en la formación de los estudiantes de Psicología teniendo en cuenta el desarrollo humano en los procesos académicos, de investigación y proyección social.</p>
COMMUNICATION PATTERN AND FAMILY TYPOLOGY OF HIGH SCHOOL ADOLESCENTS IN BOGOR
Authors: Pramono Firdanianty , Lubis Djuara P , Puspitawati Herien , Susanto Djoko 
Published: June 2017

Family communication does not occur randomly, but it is patterned by a particular scheme through two communication behavior: a conversation orientation and conformity orientation. The purpose of this study was to analyze communication patterns and typology of the family in adolescents from high schools in Bogor. The research was conducted by survey at six high schools in Bogor. Total respondents were 372 students, consisting of 206 females and 166 males aged 15-18 years old. The result: as much as 50.5% adolescents enter a high category of the orientation conversation and 49.5% as low categories. In conformity orientation, mostly teenagers (73.7%) categorized as high and 26.3% as low categories. The study also charted four types of families, those are 46.2% of consensual (high on conversational and conformity level); 4.3% of pluralist (high in conversation but low in conformity); 27.4% of protective (conversation level is low but high conformity) and 22.0% of non-interventionist (laissez faire) (low in conversational and conformity level). By gender, females are more often to have conversations with family and have higher conformiity than males.