bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treated wastewater effluent as a source of pyrethroids and fipronil at Todos Santos Bay, Mexico: Its impact on sediments and organisms
Authors: Hernández-Guzmán Félix Augusto , Macías-Zamora José Vinicio , Ramírez-Álvarez Nancy , Alvarez-Aguilar Arturo , Quezada-Hernández Cristina , Fonseca Ana Paula 
Published: June 2017

Abstract

Pyrethroids are insecticides widely used to control pests and disease vectors in residential areas and agricultural lands. Pyrethroids are emerging pollutants, and their use is a growing concern because of their toxicity potential to aquatic organisms. Todos Santos Bay and the Punta Banda estuary, 2 coastal bodies located to the south of the Southern California Bight, were studied to establish a baseline of the current conditions of pollution by pyrethroids and fipronil. Eight pyrethroids, along with fipronil and its 2 metabolites, were determined in effluents from wastewater-treatment plants (n = 3), surface sediments (n = 32), and 3 locations with mussels (Mytilus californianus, n = 9). Bifenthrin, permethrin, and cypermethrin were the most common pyrethroids found in the study areas and were widespread in sediments, mussels, and wastewater-treated effluents. Fipronil and its metabolites were detected in mussels and wastewater-treated effluents only. Total pyrethroid concentrations in sediments ranged from 0.04 to 1.95 ng/g dry weight in the Punta Banda estuary (n = 13) and from 0.07 to 6.62 ng/g dry weight in Todos Santos Bay (n = 19). Moreover, total pyrethroids in mussels ranged from 1.19 to 6.15 ng/g wet weight. Based on the toxic unit data calculated for pyrethroids and fipronil for Eohaustorius estuarius and Hyalella azteca, little to no impact is expected to the benthic population structure. Environ Toxicol Chem 2017;36:3057–3064. © 2017 SETAC
Application of a preconditioned high‐order accurate artificial compressibility‐based incompressible flow solver in wide range of Reynolds numbers
Authors: Hejranfar K. , Parseh K. 
Published: June 2017

SummaryIn the present study, the preconditioned incompressible Navier‐Stokes equations with the artificial compressibility method formulated in the generalized curvilinear coordinates are numerically solved by using a high‐order compact finite‐difference scheme for accurately and efficiently computing the incompressible flows in a wide range of Reynolds numbers. A fourth‐order compact finite‐difference scheme is utilized to accurately discretize the spatial derivative terms of the governing equations, and the time integration is carried out based on the dual time‐stepping method. The capability of the proposed solution methodology for the computations of the steady and unsteady incompressible viscous flows from very low to high Reynolds numbers is investigated through the simulation of different 2‐dimensional benchmark problems, and the results obtained are compared with the existing analytical, numerical, and experimental data. A sensitivity analysis is also performed to evaluate the effects of the size of the computational domain and other numerical parameters on the accuracy and performance of the solution algorithm. The present solution procedure is also extended to 3 dimensions and applied for computing the incompressible flow over a sphere. Indications are that the application of the preconditioning in the solution algorithm together with the high‐order discretization method in the generalized curvilinear coordinates provides an accurate and robust solution method for simulating the incompressible flows over practical geometries in a wide range of Reynolds numbers including the creeping flows.
Risk-based prioritization method for the classification of groundwater pesticide pollution from agricultural regions
Authors: Yang Yu , Lian Xin-Ying , Jiang Yong-Hai , Xi Bei-Dou , He Xiao-Song 
Published: June 2017

Abstract

Agricultural regions are a significant source of groundwater pesticide pollution. To ensure that agricultural regions with a significantly high risk of groundwater pesticide contamination are properly managed, a risk-based ranking method related to groundwater pesticide contamination is needed. In the present paper, a risk-based prioritization method for the classification of groundwater pesticide pollution from agricultural regions was established. The method encompasses 3 phases, including indicator selection, characterization, and classification. In the risk ranking index system employed here, 17 indicators involving the physicochemical properties, environmental behavior characteristics, pesticide application methods, and inherent vulnerability of groundwater in the agricultural region were selected. The boundary of each indicator was determined using K-means cluster analysis based on a survey of a typical agricultural region and the physical and chemical properties of 300 typical pesticides. The total risk characterization was calculated by multiplying the risk value of each indicator, which could effectively avoid the subjectivity of index weight calculation and identify the main factors associated with the risk. The results indicated that the risk for groundwater pesticide contamination from agriculture in a region could be ranked into 4 classes from low to high risk. This method was applied to an agricultural region in Jiangsu Province, China, and it showed that this region had a relatively high risk for groundwater contamination from pesticides, and that the pesticide application method was the primary factor contributing to the relatively high risk. The risk ranking method was determined to be feasible, valid, and able to provide reference data related to the risk management of groundwater pesticide pollution from agricultural regions. Integr Environ Assess Manag 2017;13:1052–1059. © 2017 SETAC

Key Points
A risk-based method for the classification of groundwater pesticide pollution from agricultural regions was established. The total risk was calculated by multiplying the risk value of each indicator. The risk ranking method could identify the main factors causing the risk.
Multiscale regeneration scaffold in vitro and in vivo
Authors: Chen Haiping , Xie Shikun , Yang Yuanmo , Zhang Jing , Zhang Zhuangya 
Published: June 2017

AbstractBiocompatible scaffolds play an important role in modulating tissue growth. A gelatin and sodium alginate scaffold with a unique structure produced by a combination of 3‐D printing, electrospinning, and vacuum freeze‐drying has been developed for tissue engineering. The scaffold is composed of a macrostructure, a honeycomb microporous surface morphology, and nanofibers. This structure meets the design criteria for an ideal tissue engineering scaffold. The scaffold degrades and has low cytotoxicity. The biocompatibility of the scaffold is improved by the favorable cell–matrix interaction; cells attach to the scaffold well and secrete large amounts of extracellular matrix in vitro. Rats with the scaffold implanted survived without signs of complications and the host cells infiltrated the interior of the scaffold. After 2 months in vivo, the scaffold was vascularized and contained collagen fibers. This multiscale regeneration scaffold may be suitable for tissue engineering because of its unique structure, degradation, mechanical properties, and lower cytotoxicity, which support cell infiltration and growth, and promote vascularization and generation of granulation tissue in vivo. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1218–1225, 2018.
Application of whole‐lesion histogram analysis of pharmacokinetic parameters in dynamic contrast‐enhanced MRI of breast lesions with the CAIPIRINHA‐Dixon‐TWIST‐VIBE technique
Authors: Li Zhiwei , Ai Tao , Hu Yiqi , Yan Xu , Nickel Marcel Dominik , Xu Xiao , Xia Liming 
Published: June 2017

PurposeTo investigate the application of whole‐lesion histogram analysis of pharmacokinetic parameters for differentiating malignant from benign breast lesions on dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI).Materials and MethodsIn all, 92 women with 97 breast lesions (26 benign and 71 malignant lesions) were enrolled in this study. Patients underwent dynamic breast MRI at 3T using a prototypical CAIPIRINHA‐Dixon‐TWIST‐VIBE (CDT‐VIBE) sequence and a subsequent surgery or biopsy. Inflow rate of the agent between plasma and interstitium (Ktrans), outflow rate of agent between interstitium and plasma (Kep), extravascular space volume per unit volume of tissue (ve) including mean value, 25th/50th/75th/90th percentiles, skewness, and kurtosis were then calculated based on the whole lesion. A single‐sample Kolmogorov–Smirnov test, paired t‐test, and receiver operating characteristic curve (ROC) analysis were used for statistical analysis.ResultsMalignant breast lesions had significantly higher Ktrans, Kep, and lower ve in mean values, 25th/50th/75th/90th percentiles, and significantly higher skewness of ve than benign breast lesions (all P < 0.05). There was no significant difference in kurtosis values between malignant and benign breast lesions (all P > 0.05). The 90th percentile of Ktrans, the 90th percentile of Kep, and the 50th percentile of ve showed the greatest areas under the ROC curve (AUC) for each pharmacokinetic parameter derived from DCE‐MRI. The 90th percentile of Kep achieved the highest AUC value (0.927) among all histogram‐derived values.ConclusionThe whole‐lesion histogram analysis of pharmacokinetic parameters can improve the diagnostic accuracy of breast DCE‐MRI with the CDT‐VIBE technique. The 90th percentile of Kep may be the best indicator in differentiation between malignant and benign breast lesions.Level of Evidence: 4Technical Efficacy Stage: 2J. Magn. Reson. Imaging 2018;47:91–96.
Diffusion kurtosis MRI versus conventional diffusion‐weighted imaging for evaluating inflammatory activity in Crohn's disease
Authors: Huang Li , Li Xue‐hua , Huang Si‐yun , Zhang Zhong‐wei , Yang Xu‐feng , Lin Jin‐jiang , Jiang Meng‐jie , Feng Shi‐ting , Sun Can‐hui , Li Zi‐ping 
Published: June 2017

PurposeTo assess the efficacy of diffusion kurtosis imaging (DKI) and to compare DKI‐derived parameters with that of conventional diffusion‐weighted imaging (DWI) for grading the inflammatory activity of Crohn's disease (CD).Materials and MethodsIn all, 38 patients with CD underwent 3T magnetic resonance enterography (MRE) with DKI (b values of 0–2000 s/mm2). The inflammatory activity of the bowel segments was graded by magnetic resonance index of activity (MaRIA) as inactive (<7), mild (≥7 and <11), or moderate‐severe (≥11). Apparent diffusion for non‐Gaussian distribution (Dapp) and apparent kurtosis coefficient (Kapp) on DKI as well as apparent diffusion coefficient (ADC) on DWI were compared.ResultsIn all, 86 bowel segments including inactive (20), mild (19), and moderate‐severe (47) CD were analyzed. The differences in Kapp, Dapp, and ADC among inactive, mild, and moderate‐severe CD were significant (all P < 0.05). Kapp (r = 0.862), Dapp (r = −0.755), and ADC (r = −0.713) correlated well with MaRIA in all segments. Stronger correlation with MaRIA in moderate‐severe CD was found for Kapp (r = 0.647) than that of Dapp (r = −0.414) and ADC (r = −0.580). Receiver operating characteristic (ROC) curve analysis showed high accuracy of Kapp, Dapp, and ADC for differentiating active from inactive CD (AUC: 0.953 for Kapp, 0.944 for Dapp, 0.907 for ADC) as well as differentiating inactive‐mild from moderate‐severe CD (AUC: 0.946 for Kapp, 0.887 for Dapp, 0.846 for ADC). The threshold Kapp of 0.731 allowed differentiation of active from inactive CD with 89.4% sensitivity and 95% specificity.ConclusionDKI of CD is clinically feasible and might be superior to conventional DWI for grading the inflammatory activity of CD.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:702–709.
Concise Review: Criteria for Chamber-Specific Categorization of Human Cardiac Myocytes Derived from Pluripotent Stem Cells
Authors: Kane Christopher , Terracciano Cesare M. N. 
Published: June 2017

Abstract
Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential application in almost all areas of cardiovascular research. A current major goal of the field is to build on the past success of differentiation strategies to produce CMs with the properties of those originating from the different chambers of the adult human heart. With no anatomical origin or developmental pathway to draw on, the question of how to judge the success of such approaches and assess the chamber specificity of PSC-CMs has become increasingly important; commonly used methods have substantial limitations and are based on limited evidence to form such an assessment. In this article, we discuss the need for chamber-specific PSC-CMs in a number of areas as well as current approaches used to assess these cells on their likeness to those from different chambers of the heart. Furthermore, describing in detail the structural and functional features that distinguish the different chamber-specific human adult cardiac myocytes, we propose an evidence-based tool to aid investigators in the phenotypic characterization of differentiated PSC-CMs.
Perspectives and Practices of Athletic Trainers and Team Physicians Implementing the 2010 NCAA Sickle Cell Trait Screening Policy
Authors: McDonald Mary Anne , Creary Melissa S. , Powell Jill , Daley Lori‐Ann , Baker Charlotte , Royal Charmaine DM 
Published: June 2017

AbstractSickle cell trait (SCT) is usually benign. However, there are some conditions that may lead to SCT‐related problems and put athletes with the trait at particular risk. In 2010 the National Collegiate Athletic Association (NCAA) issued a policy that required all Division I (DI) student‐athletes to confirm their SCT status or sign a liability waiver to opt out of testing. Athletic trainers and team physicians play key roles in the policy implementation and we examined their perceptions and practices. Between December 2013 and March 2014 we interviewed 13 head athletic trainers and team physicians at NCAA Division I colleges and universities in North Carolina. We used an interview guide with open‐ended questions covering knowledge of SCT, historical screening and education practices, current implementation, and policy benefits and challenges. Participants were knowledgeable about SCT and thought the policy was beneficial in providing SCT health information to and for student‐athletes. Schools varied in provision of genetic counseling, offering the waiver, SCT tests administered, and other aspects. Challenges included: insufficient guidance from the NCAA; financial considerations; and misunderstanding of the relationships of race and ancestry to SCT risk. Athletic staff found the policy valuable, but felt it needs clarity and standardization.
Identification and Characterization of a Novel Thermophilic, Organic Solvent Stable Lipase of Bacillus from a Hot Spring
Authors: Li Jiang , Liu Xiumeng 
Published: June 2017

AbstractA novel lipase gene lip256 was cloned and identified from the genomic library of hot spring strain Bacillus sp. HT19. The deduced amino acid sequence of lip256 has less than 32% identity to a predicted esterase (Cog1752) from Photobacterium leiognathi lrivu.4.1 and contains a novel motif (GTSAG) that differs from other clusters in the lipase superfamily. Following purification, a single band was obtained with a molecular mass of 33 kDa by SDS‐PAGE, and the optimal temperature and pH for lipolytic activity of Lip25 were 70 °C and 9.0, respectively. Lip256 exhibited high activity at high temperatures, with 40% maximum activity at 80 °C and good stability at temperatures ranges between 50 and 80 °C. Additionally, the enzyme was highly stable in the presence of butyl‐alcohol, glycerol, acetonitrile, pyridine, and urea. However, the presence of acetone, methanol, trichloromethane, petroleum ether, hexane, tert‐butanol, isopropanol, dithiothreitol, ethylenediaminetetraacetic acid, polyhexamethylene biguanide, dimethyl sulfoxide, benzene, Triton X‐100, Tween‐20, Tween‐80, and sodium dodecyl sulfate suppressed or absolutely inhibited enzyme activity. Furthermore, Ca2+, Mg2+, and Cu2+ suppressed enzyme activity, whereas Na+, Fe3+, K+, Fe2+, and Sr2+ enhanced enzyme activity. The unique characteristics of novel lipase Lip256, including its thermo‐alkaliphilic performance, high tolerance toward metal ions, inhibitors, and detergents, and high stability in organic solvents, implied that this enzyme might be an interesting candidate for industrial processes.
Insolvency administrator’s incentives and the tradeoff between creditor satisfaction and efficiency in bankruptcy procedures
Authors: Frieden Matthias , Wielenberg Stefan 
Published: June 2017

AbstractAn insolvency administrator replaces the manager of an insolvent firm to devise and organize a liquidation or reorganization plan in the creditors’ interest. In the course of the process, the insolvency administrator presents the most favourable option from his perspective, and the creditors choose to accept or reject this plan. Conflicts of interest arise because the insolvency administrator, as the better-informed party, considers in his proposal liability risks and reputational issues that are beyond the creditors’ scope. We model this conflict as a Bayesian game and find that, under those compensation schemes typically used in real-world regulations, optimal creditor satisfaction and efficient decisions concerning the economic future of the insolvent firm will never be achieved simultaneously.
Gender matters: Experiences and consequences of digital dating abuse victimization in adolescent dating relationships
Authors: Reed Lauren A. , Tolman Richard M. , Ward L. Monique 
Published: June 2017

ABSTRACTDigital dating abuse (DDA) behaviors include the use of digital media to monitor, control, threaten, harass, pressure, or coerce a dating partner. In this study, 703 high school students reported on the frequency of DDA victimization, whether they were upset by these incidents, and how they responded. Results suggest that although both girls and boys experienced DDA at similar rates of frequency (with the exception of sexual coercion), girls reported that they were more upset by these behaviors. Girls also expressed more negative emotional responses to DDA victimization than boys. Although DDA is potentially harmful for all youth, gender matters. These findings suggest that the experience and consequences of DDA may be particularly detrimental for girls.
Flibanserin in Postmenopausal Women with Hypoactive Sexual Desire Disorder: Results of the PLUMERIA Study
Authors: Portman David J. , Brown Louise , Yuan James , Kissling Robert , Kingsberg Sheryl A. 
Published: June 2017

Abstract

Background
Hypoactive sexual desire disorder (HSDD) is a common sexual disorder in younger and older women. Flibanserin is approved for the treatment of acquired generalized HSDD in premenopausal women only. The efficacy of flibanserin for postmenopausal women with HSDD was demonstrated in the first of two North American randomized, double-blinded, placebo-controlled trials (SNOWDROP).

Aim
To evaluate the safety and efficacy of flibanserin in postmenopausal women with HSDD in a second randomized, double-blinded, placebo-controlled trial (PLUMERIA).

Methods
Naturally postmenopausal women were randomly assigned to receive flibanserin (100 mg/d) or placebo. Efficacy outcomes were assessed using the last-observation-carried-forward imputation method.

Outcomes
Safety assessment included incidence of adverse events. Primary efficacy outcomes were the number of satisfying sexual events and the Female Sexual Function Index desire domain (FSFI-d) score.

Results
The study population (flibanserin, n = 376; placebo, n = 369) included primarily white women (84.7%), with a mean age of 56.1 years and a mean HSDD duration of 5.0 years. When the study was discontinued early by the sponsor, 45.3% of randomly assigned patients had completed week 16 (which served as the primary analysis time point). The most common adverse events in flibanserin-treated patients were insomnia (7.7%), somnolence (6.9%), and dizziness (6.4%). Improvement from baseline to week 16 (last-observation-carried-forward) in FSFI-d score was significantly greater for flibanserin compared with placebo (P = .011); however, the between-group comparison for satisfying sexual events did not reach statistical significance.

Clinical Implications
Considered with the findings of the previous randomized controlled trial (SNOWDROP), the results of this study support the safety and efficacy of flibanserin in postmenopausal women.

Strengths and Limitations
This was a well-designed randomized, placebo-controlled trial. A key limitation was early discontinuation by the study sponsor, which decreased the sample size. In addition, the validity of satisfying sexual events as a primary outcome measurement in HSDD studies has been called into question (but was required by the US Food and Drug Administration as a primary end point in studies of female sexual dysfunction at the time this study was conducted).

Conclusion
Flibanserin was generally well tolerated in this population of naturally postmenopausal women. Despite the greatly decreased power to detect improvement compared with placebo on the efficacy measurements used, results suggest that flibanserin could be efficacious in postmenopausal women with HSDD.
Distal Corporal Anchoring Stitch: A Technique to Address Distal Corporal Crossovers and Impending Lateral Extrusions of a Penile Prosthesis
Authors: Antonini Gabriele , Busetto Gian Maria , Del Giudice Francesco , Ferro Matteo , Chung Benjamin I. , Conti Simon L. , Suarez Sarmiento Alfredo , Pacchiarotti Arianna , De Berardinis Ettore , Perito Paul E. 
Published: June 2017

Abstract

Background
Unidentified distal crossovers, delayed distal crossovers, and impending lateral extrusion are complications of penile prosthesis implant insertion but are not as common as prosthesis infection or mechanical failure.

Aim
To evaluate results of a surgical technique, the distal corporal anchoring stitch, that addresses fixation of the penile prosthesis in patients with these complications.

Methods
A lateral sub-coronal incision is used on the side where the crossover or laterally extruding cylinder should be positioned. Dissection is carried through the Buck fascia, followed by a transverse incision of the tunica albuginea, where the distal aspect of the affected cylinder is delivered. A 4-0 PDS suture is threaded through the distal cylinder ring of the implant. A new, properly positioned intracorporal channel is created and the suture is passed through the distal end of the channel. Once the suture is through the glans and the cylinder is in the correct position, a small cruciate incision is made on the glans at the location of the anchor stitch. The suture is tied with the knot buried in the glans tissue.

Outcomes
Fifty-three patients underwent treatment of their distal penile implant crossover with a distal corporoplasty using this method and their anatomic and functional outcomes and overall satisfaction were evaluated.

Results
This technique ensured that the cylinder remained in the newly created, appropriately positioned channel. No patients developed infections, wound-healing defect, glandular hypoesthesia, anesthesia, or altered sensation or pain in the glans related to the suture and only two reported recurrence of a lateral herniation that did not require further treatment.

Clinical Implications
Distal fixation of the penile prosthesis is a useful surgical adjunct to treating patients with prosthetic lateral extrusions or crossovers that can be applied in almost all cases.

Strengths and Limitations
Considering these rare complications, our experience is based on a relatively large number of patients and showed a low incidence of complications and a high satisfaction rate. The main limitation of this study is the retrospective nature of the data and the series included patients from two high-volume surgeons that might not be generalizable to all practices.

Conclusion
The distal corporal anchoring stitch is safe and effective in securing distal fixation of the extruding inflatable penile prosthesis.