bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Trypanosoma cruzi transmission dynamics in an acute Chagas disease outbreak using next-generation sequencing
Authors: Cruz-Saavedra Lissa , Ospina Carlos , Gutiérrez Stivenn A. , Jaimes-Dueñez Jeiczon , Cantillo-Barraza Omar , Hernández Carolina , Álvarez Francisco , Blanco María , Leal Bernardo , Martínez Lida , Medina Manuel , Medina Mabel , Valdivieso Silvia , Ramirez Celis Lauren Natalia , Patiño Luz H. , Ramírez Juan David 
Published: September 2024

Abstract
Background
Chagas disease (CD), caused by Trypanosoma cruzi, poses a major global public health challenge. Although vector-borne transmission is the primary mode of infection, oral transmission is increasingly concerning.

Methods
This study utilized long-amplicon-based sequencing (long-ABS), focusing on the 18S rRNA gene, to explore T. cruzi’s genetic diversity and transmission dynamics during an acute CD outbreak in Colombia, an area without domestic infestation.

Results
Analyzing samples from five patients and five T. cruzi-positive marsupial samples, we identified coinfections between T. cruzi and Trypanosoma rangeli, mixed T. cruzi DTUs, suggesting possible links between human and marsupial T. cruzi infections. Coexistence of TcI, TcIV and T. rangeli suggests marsupial secretions as the possible source of T. cruzi transmission. Our investigation revealed diversity loss in DTUs TcIV and T. rangeli in humans after infection and in marsupial samples after culture.

Conclusion
These findings provide significant insights into T. cruzi dynamics, crucial for implementing control and prevention strategies.

Graphical abstract
The impact of maturation level, not chronological age, on attentional control: implications for sports injury prevention in female adolescents
Authors: Grinberg Adam , Hanzlíková Ivana , Lehnert Michal , Abdollahipour Reza 
Published: September 2024

Abstract
Background
Non-contact injuries are highly prevalent among young athletes and occur particularly in situations that require fast decision making and divided attention. Administering relevant neurocognitive tests could help identify deficiencies in these cognitive abilities and thus potentially mitigate injury risk. However, processes such as selective attention and response inhibition might depend to some extent on the athlete’s maturation stage. We aimed to examine the effect of maturation on selective visual attention and response inhibition among adolescent volleyball players.

Methods
In this cross-sectional study, 52 female adolescents (age 12.3 ± 2.1 years) performed an Eriksen Flankers task. Participants were divided into subgroups based on their estimated adult stature, using the Khamis & Roche method: Pre-pubertal (PRE; n = 13, age: 9.9 ± 1.3), early-puberty (EPUB; n = 7, age: 10.5 ± 0.6), mid-puberty (MPUB; n = 8, age: 12.6 ± 0.8) and late puberty (LPUB; n = 24, age: 14.1 ± 0.9). Analyses of covariance (ANCOVA) were performed on congruent and incongruent reaction times (RT), with corresponding success rates (% correct responses) as covariate. Flanker interference effect was tested using ANOVA. Correlations were further examined between the dependent variables and participants’ chronological age.

Results
There was a significant group effect, with PRE demonstrating longer RT compared with LPUB (P < 0.001) for both congruent and incongruent RT. Moderate negative correlations were observed between age and RT (Rp = -0.695, Rp = -0.614 for congruent and incongruent RT, respectively) and low positive correlations between age and incongruent success rate (Rs = 0.318). Low to moderate correlations were also observed within the LPUB group for RT (Rp = -0.431–-0.532) and success rate (negative Rs = -574 for congruent and positive Rs = 0.417 for incongruent). There were no group differences nor age associations with interference effect.

Conclusions
Our findings indicate that information processing and selective visual attention are superior at late maturation compared with early maturation among female adolescents. The same cannot be said for response inhibition, which did not differ between maturation groups. Similar tendencies were observed with regards to chronological age, but not entirely explained by it. Maturation level, rather than chronological age, should guide practitioners during sport participation and injury prevention programs for young athletes, whose neurocognitive abilities are not yet fully developed, placing them at risk for non-contact injuries.
Rewiring cattle movements to limit infection spread
Authors: Morel-Journel Thibaut , Ezanno Pauline , Vergu Elisabeta 
Published: September 2024

AbstractCattle tracing databases have become major resources for representing demographic processes of livestock and assessing potential risk of infections spreading by trade. The herds registered in these databases are nodes of a network of commercial movements, which can be altered to lower the risk of disease transmission. In this study, we develop an algorithm aimed at reducing the number of infected animals and herds, by rewiring specific movements responsible for trade flows from high- to low-prevalence herds. The algorithm is coupled with a generic computational model based on the French cattle movement tracing database (BDNI), and used to describe different scenarios for the spread of infection within and between herds from a recent outbreak (epidemic) or a five-year-old outbreak (endemic). Results show that rewiring successfully contains infections to a limited number of herds, especially if the outbreak is recent and the estimation of disease prevalence frequent, while the respective impact of the parameters of the algorithm depend on the infection parameters. Allowing any animal movement from high to low-prevalence herds reduces the effectiveness of the algorithm in epidemic settings, while frequent and fine-grained prevalence assessments improve the impact of the algorithm in endemic settings. Our approach focusing on a few commercial movements is expected to lead to substantial improvements in the control of a targeted disease, although changes in the network structure should be monitored for potential vulnerabilities to other diseases. This general algorithm could be applied to any network of controlled individual movements liable to spread disease.
Respiratory effects of prone position in COVID-19 acute respiratory distress syndrome differ according to the recruitment-to-inflation ratio: a prospective observational study
Authors: Lai Christopher , Shi Rui , Jelinski Ludwig , Lardet Florian , Fasan Marta , Ayed Soufia , Belotti Hugo , Biard Nicolas , Guérin Laurent , Fage Nicolas , Fossé Quentin , Gobé Thibaut , Pavot Arthur , Roger Guillaume , Yhuel Alex , Teboul Jean-Louis , Pham Tai , Monnet Xavier ,   for the EVALPRO Study group
Published: September 2024

Abstract
Background
Improvements in oxygenation and lung mechanics with prone position (PP) in patients with acute respiratory distress syndrome (ARDS) are inconstant. The objectives of the study were (i) to identify baseline variables, including the recruitment-to-inflation ratio (R/I), associated with a positive response to PP in terms of oxygenation (improvement of the ratio of arterial oxygen partial pressure over the inspired oxygen fraction (PaO2/FiO2) ≥ 20 mmHg) and lung mechanics; (ii) to evaluate whether the response to the previous PP session is associated with the response to the next session.

Methods
In this prospective, observational, single-center study in patients who underwent PP for ARDS due to COVID-19, respiratory variables were assessed just before PP and at the end of the session. Respiratory variables included mechanical ventilation settings and respiratory mechanics variables, including R/I, an estimate of the potential for lung recruitment compared to lung overinflation.

Results
In 50 patients, 201 PP sessions lasting 19 ± 3 h were evaluated. Neuromuscular blockades were used in 116 (58%) sessions. The PaO2/FiO2 ratio increased from 109 ± 31 mmHg to 165 ± 65 mmHg, with an increase ≥ 20 mmHg in 142 (71%) sessions. In a mixed effect logistic regression, only pre-PP PaO2/FiO2 (OR 1.12 (95% CI [1.01–1.24])/every decrease of 10 mmHg, p = 0.034) in a first model and improvement in oxygenation at the previous PP session (OR 3.69 (95% CI [1.27–10.72]), p = 0.017) in a second model were associated with an improvement in oxygenation with PP. The R/I ratio (n = 156 sessions) was 0.53 (0.30–0.76), separating lower- and higher-recruiters. Whereas PaO2/FiO2 improved to the same level in both subgroups, driving pressure and respiratory system compliance improved only in higher-recruiters (from 14 ± 4 to 12 ± 4 cmH2O, p = 0.027, and from 34 ± 11 to 38 ± 13 mL/cmH2O, respectively, p = 0.014).

Conclusions
A lower PaO2/FiO2 at baseline and a positive O2-response at the previous PP session are associated with a PP-induced improvement in oxygenation. In higher-recruiters, lung mechanics improved along with oxygenation. Benefits of PP could thus be greater in these patients.
An adaptive approach for integrating primary user behavior in compressive spectrum sensing
Authors: Tawfik Ahmed A. , Abuelenin Sherif M. , Abdelkader Mohamed F. 
Published: September 2024

AbstractCompressive sensing (CS) has been widely used to sense the wideband spectrum with fewer measurements by taking advantage of radio spectrum underutilization. As new smart devices, such as IoT devices, smart home devices, and wearables, use batteries and have limited memory, more research is needed to reduce the overuse of cognitive radio (CR) resources through spectrum sensing. To reduce the number of compressive measurements required for spectrum recovery, researchers proposed approaches like weighted and sequential compressive sensing. In this paper, we estimate the primary user’s (PU) behavior statistics and use the estimated information in a novel weighted sequential compressive spectrum sensing approach. Our proposed approach can reduce and adapt the number of measurements and the sensing time to the changing number of active channels in a dynamically changing wideband spectrum.
Preparation of chitosan oligosaccharides from chitosan of tenebrio molitor and its prebiotic activity
Authors: Kim Hyemi , Cheon Ga Yeong , Kim Jae Hee , Choi Ra-Yeong , Kim In-Woo , Suh Hyung Joo , Hong Ki-Bae , Han Sung Hee 
Published: September 2024

AbstractThis study aimed to establish the optimal production conditions for mealworm chitosan oligosaccharides (MCOS) using the response surface methodology and measure the prebiotic effect of MCOS prepared on cecal microbiota through in vitro anaerobic fermentation. The optimal conditions for MCOS production using chitosanase were 2.5% substrate, 30 mg/g enzyme, and 6 h reaction time. Matrix-assisted laser desorption ionization-time of flight mass spectrometry, Fourier transform infrared spectroscopy, and in vitro assays to confirm that the chemical structure and physicochemical properties of MCOS are similar to those of commercially available chitosan oligosaccharides. The growth of Lactobacillus acidophilus, Lacticaseibacillus casei, and Bifidobacterium bifidum was increased by MOCS and confirmed that the prebiotic effect of MCOS was significant in a concentration-dependent manner. The addition of 1% and 2% MCOS to in vitro anaerobic fermentation resulted in changes in the content of short-chain fatty acids (SCFAs) and an increase in Verrucomicrobiota abundance compared with the control. In the case of Romboutsia, Turicibacter, and Akkermansia, a significant increase was confirmed in the MCOS-containing groups compared to that in the control group. Compared to 2% MCOS, 1% MCOS more significantly affected Lactobacillus levels. MCOS produced by chitosanase under optimal conditions contains oligosaccharides with 2–6 degree of polymerization and exerts a prebiotic effect that affects changes in the SCFA content and microbiota composition in the cecum.
Machine learning and deep learning models based grid search cross validation for short-term solar irradiance forecasting
Authors: El-Shahat Doaa , Tolba Ahmed , Abouhawwash Mohamed , Abdel-Basset Mohamed 
Published: September 2024

AbstractIn late 2023, the United Nations conference on climate change (COP28), which was held in Dubai, encouraged a quick move from fossil fuels to renewable energy. Solar energy is one of the most promising forms of energy that is both sustainable and renewable. Generally, photovoltaic systems transform solar irradiance into electricity. Unfortunately, instability and intermittency in solar radiation can lead to interruptions in electricity production. The accurate forecasting of solar irradiance guarantees sustainable power production even when solar irradiance is not present. Batteries can store solar energy to be used during periods of solar absence. Additionally, deterministic models take into account the specification of technical PV systems and may be not accurate for low solar irradiance. This paper presents a comparative study for the most common Deep Learning (DL) and Machine Learning (ML) algorithms employed for short-term solar irradiance forecasting. The dataset was gathered in Islamabad during a five-year period, from 2015 to 2019, at hourly intervals with accurate meteorological sensors. Furthermore, the Grid Search Cross Validation (GSCV) with five folds is introduced to ML and DL models for optimizing the hyperparameters of these models. Several performance metrics are used to assess the algorithms, such as the Adjusted R2 score, Normalized Root Mean Square Error (NRMSE), Mean Absolute Deviation (MAD), Mean Absolute Error (MAE) and Mean Square Error (MSE). The statistical analysis shows that CNN-LSTM outperforms its counterparts of nine well-known DL models with Adjusted R2 score value of 0.984. For ML algorithms, gradient boosting regression is an effective forecasting method with Adjusted R2 score value of 0.962, beating its rivals of six ML models. Furthermore, SHAP and LIME are examples of explainable Artificial Intelligence (XAI) utilized for understanding the reasons behind the obtained results.
The potential use of nature-based solutions as natural hazard mitigation measure for linear infrastructure in the Nordic Countries
Authors: Capobianco Vittoria , Palau Rosa Maria , Solheim Anders , Gisnås Kjersti , Gilbert Graham , Danielsson Per , van der Keur Peter 
Published: September 2024

Abstract
Background
Reliable infrastructure is vital for Nordic societies, but they face escalating climate risks. Climate change is increasing magnitude and frequency of floods, storms, and landslides, making adaptive solutions crucial.

Methods
This review explores Nature-Based Solutions (NbS) for mitigating natural hazards along Nordic linear infrastructure. The motivation of the review comes as result of a preliminary survey conducted among to the main infrastructure managers in the Fennoscandian peninsula. The objective was to pinpoint the natural hazards that pose greatest concern under future climate scenarios, as well as to understand which specific information is needed to adopt NbS

Results
Floods, erosion, landslides and rockfalls emerged as primary hazards of concern for the infrastructure owners, hence the review process was focused only on NbS aimed at mitigating the effects of these specific hazards.
A total of 78 documents were identified from the review process and were integrated with examples and case studies from other relevant on-going and past projects. Despite only a few of the NbS identified in these documents were directly implemented for linear infrastructure such as roads and railways, and none dealing with electric grids, several NbS were identified to have a potential for implementation for Nordic linear infrastructure.
A list of NbS options, not all implemented along linear infrastructure but with potential for it, is provided. This list is meant to serve as “vade mecum” for a quick and easy access to NbS as mitigation options for linear infrastructure managers in the Nordic Countries. The NbS are classified in green, blue, green/blue and hybrid approaches, and supported by examples of case studies both in the Nordic Countries as well as countries having similar climates.

Conclusions
This review underlines the challenges and opportunities of adopting NbS. Challenges such as the lack of expertise, space and climate constraints, and path dependency on adoption of traditional infrastructure must be addressed to mainstream NbS. The review highlights the importance of standardization, European guidelines, and technical manuals in promoting NbS adoption among infrastructure managers, as well as the necessity of accounting for the wider co-benefits of NbS, including carbon sequestration, biodiversity and ecosystem services.
This paper contributes to the understanding of NbS as potential natural hazards mitigation options for Nordic infrastructure networks in the face of evolving climate risks, providing valuable insights for infrastructure managers and policymakers alike.
Global burden of benign prostatic hyperplasia, urinary tract infections, urolithiasis, bladder cancer, kidney cancer, and prostate cancer from 1990 to 2021
Authors: Zi Hao , Liu Meng-Yang , Luo Li-Sha , Huang Qiao , Luo Peng-Cheng , Luan Hang-Hang , Huang Jiao , Wang Dan-Qi , Wang Yong-Bo , Zhang Yuan-Yuan , Yu Ren-Peng , Li Yi-Tong , Zheng Hang , Liu Tong-Zu , Fan Yu , Zeng Xian-Tao 
Published: September 2024

Abstract
Background
The burden of common urologic diseases, including benign prostatic hyperplasia (BPH), urinary tract infections (UTI), urolithiasis, bladder cancer, kidney cancer, and prostate cancer, varies both geographically and within specific regions. It is essential to conduct a comprehensive and precise assessment of the global burden of urologic diseases.

Methods
We obtained data on incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for the aforementioned urologic diseases by age, sex, location, and year from the Global Burden of Disease (GBD) 2021. We analyzed the burden associated with urologic diseases based on socio-demographic index (SDI) and attributable risk factors. The trends in burden over time were assessed using estimated annual percentage changes (EAPC) along with a 95% confidence interval (CI).

Results
In 2021, BPH and UTI were the leading causes of age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR), with rates of 5531.88 and 2782.59 per 100,000 persons, respectively. Prostate cancer was the leading cause of both age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR), with rates of 12.63 and 217.83 per 100,000 persons, respectively. From 1990 to 2021, there was an upward trend in ASIR, ASPR, ASMR, and ASDR for UTI, while urolithiasis showed a downward trend. The middle and low-middle SDI quintile levels exhibited higher incidence, prevalence, mortality, and DALYs related to UTI, urolithiasis, and BPH, while the high and high-middle SDI quintile levels showed higher rates for the three cancers. The burden of these six urologic diseases displayed diverse age and sex distribution patterns. In 2021, a high body mass index (BMI) contributed to 20.07% of kidney cancer deaths worldwide, while smoking accounted for 26.48% of bladder cancer deaths and 3.00% of prostate cancer deaths.

Conclusions
The global burden of 6 urologic diseases presents a significant public health challenge. Urgent international collaboration is essential to advance the improvement of urologic disease management, encompassing the development of effective diagnostic screening tools and the implementation of high-quality prevention and treatment strategies.
Giant gallbladder cyst with acute cholecystitis: a case report
Authors: Terashi Takahiro , Shirabe Kohjiro , Inokuchi Shoichi , Tsutsumi Satoshi , Sasaki Atsushi , Ikebe Masahiko , Bandoh Toshio , Wada Junpei , Urabe Shogo , Utsunomiya Tohru 
Published: September 2024

Abstract
Background
Gallbladder cysts are rare diseases with very few reported cases, and no clinical or histological definition has been established. Furthermore, cases of giant cysts outside the gallbladder wall are extremely rare. We report a rare case of giant gallbladder cyst with acute cholecystitis.

Case presentation
An 85-year-old woman with appetite loss and right lower abdominal pain lasting 2 days presented to our hospital. At first, the patient’s abdominal pain was mild to moderate with no fever. Blood tests revealed a white blood cell count of 10,950/mm3, and the C-reactive protein (CRP) level was 14.35 mg/dl. A contrast-enhanced computed tomography (CT) scan of the abdomen revealed a grossly distended gallbladder (14.5 × 14.5 × 8.7 cm) with an incarcerated stone in the cystic duct. The patient was treated by percutaneous transhepatic gallbladder drainage (PTGBD) with 735 ml of drainage fluid. Oral contrast magnetic resonance cholangiopancreatography (MRCP) revealed that gallbladder swelling remained (14.0 × 6.5 cm) 3 days after PTGBD. We performed laparoscopic cholecystectomy 6 days after PTGBD. Because of the severe adhesion around the junction of the cystic and common bile ducts, we performed open cholecystectomy.
The resected specimen was 14 × 11 cm in size and consisted of a gallbladder (6 × 7 cm) with a stone (2.4 × 1.8 cm) in the gallbladder and a large cystic lesion (18 × 18 cm) outside the gallbladder wall. The cystic lesion had a wall thickness of 6 to 12 mm and internal septal structures and contained hemorrhagic and necrotic tissue.
Histological examination revealed that the specimens showed a mildly swollen gallbladder and a cystic lesion on the outside of the gallbladder wall, adjacent to the gallbladder wall, with wall thickening and inflammation. The cystic lesion suggested gallbladder duplication, gallbladder diverticulum or extension of the Rokitansky-Aschoff sinus (RAS). There was no malignancy. The patient’s postoperative course was uneventful, and she was discharged 5 days after the operation.

Conclusion
We present a very rare case of giant gallbladder cyst with acute cholecystitis revealed by cholecystectomy.
White coat hypertension in acute retinal vein occlusion
Authors: Aoki Shuichiro , Suzuki Haruyuki , Ueda Kohei , Kitamoto Kohdai , Azuma Keiko , Obata Ryo 
Published: September 2024

Abstract
Purpose
To investigate the association between white-coat hypertension (WCH) and acute retinal vein occlusion (RVO).

Methods
In this retrospective case-control study, patients aged 40 years or older diagnosed with acute-phase RVO were included. Patients with other pathologies served as non-RVO controls. Blood pressure (BP) was measured in the office during their initial visit, and information about home BP and hypertension (HTN) medication was obtained through interviews. After 1:2 age and sex-matching between the RVO and non-RVO groups, the proportions of HTN cases were compared. A similar comparison was made in subgroups with or without HTN medication.

Results
Fifty-one patients with RVO and 102 with non-RVO were included in the analysis. For the entire cohort, the RVO group exhibited a significantly greater proportion of WCH and sustained HTN compared to the non-RVO group. In the subgroup without HTN treatment, the proportion of WCH or sustained HTN was still significantly higher in the RVO group. However, in the subgroup receiving HTN treatment, the proportion of WCH or sustained HTN was higher in the RVO group than in the non-RVO group, though not statistically significant.

Conclusion
This case-control study suggests that WCH may be associated with RVO, particularly in patients without HTN treatment. Given that interventions for WCH have not been standardized, a more detailed and prospective study is warranted to elucidate the risk of WCH for RVO and other retinal vascular diseases.