bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shuxuening injection for treating acute ischemic stroke: a PRISMA-compliant systematic review and meta-analysis of randomized controlled trials
Authors: Zhan Jie , Xu Xiaowen , Zhu Yanzhen , Liu Lin , Chen Hongxia , Zhan Lechang 
Published: October 2024

Background: Using Shuxuening injection (SXNI) for acute ischemic stroke (AIS) is popular in China, but its efficacy and safety remain controversial.Purpose: This study aims to assess the efficacy and safety of SXNI as an add-on therapy for AIS.Study design: Systematic review and meta-analysis.Methods: We searched for randomized controlled trials (RCTs) on SXNI for AIS in seven databases and two clinical trial registration platforms from their inception to January 2023. We used the Cochrane risk of bias tool to assess the methodological quality of the included studies and performed the meta-analysis with R software. The primary outcome was clinical efficacy, assessed by the clinical effective rate (CER). The secondary outcomes were neurological function, activities of daily living (ADL), and adverse events (AEs).Results: In total, 116 studies with 12,401 participants were included in this review. Fifteen (12.9%) studies were judged to be of moderate to high quality. SXNI plus conventional treatments (CTs) improved the CER compared with CTs alone (risk ratio [RR]: 1.21, 95% confidence interval [CI]: 1.17–1.25, p &lt; 0.0001) or CTs plus other injections (RR: 1.18, 95% CI: 1.15–1.21, p &lt; 0.0001). SXNI plus CTs reduced the National Institute of Health Stroke Scale score compared with CTs alone (mean difference [MD]: −4.00, 95% CI: −5.22 to −2.78, p &lt; 0.0001) or CTs plus other injections (MD: −2.28, 95% CI: −3.41 to −1.16, p &lt; 0.0001). SXNI plus CTs also decreased the Chinese Stroke Scale score compared with CTs alone (MD: −5.01, 95% CI: −7.38 to −2.65, p &lt; 0.0001) or CTs plus other injections (MD: −4.31, 95% CI: −5.75 to −2.88, p &lt; 0.0001). SXNI plus CTs was superior for increasing the Barthel index score compared with CTs alone (MD: 11.58, 95% CI: 8.27–14.90, p &lt; 0.0001) or CTs plus other injections (MD: 5.43, 95% CI: 0.48–10.39, p = 0.0317). The level of evidence for each outcome was assessed as low to very low. The most common AEs of SXNI were cardiovascular system events, and all these AEs were mild.Conclusion: SXNI combined with CTs maybe better than CTs alone or CTs plus other injections for improving the clinical efficacy, neurological function, and ADL of AIS patients, with relatively reliable safety. However, due to the low quality of the included studies, more rigorously designed RCTs with large sample sizes should be conducted in the future.Systematic Review Registration:www.crd.york.ac.uk, identifier (CRD42023418565).
Green rush and red warnings: Retrospective chart review of adverse events of interactions between cannabinoids and psychotropic drugs
Authors: Chrobak Adrian Andrzej , Woroń Jarosław , Siwek Marcin 
Published: October 2024

AimOur objective was to systematically assess the prevalence and clinical features of adverse events related to interactions between cannabinoids and psychotropic drugs through a retrospective chart review.Methodology1586 adverse event reports were assessed. Cases included in the analysis showed a high probability of a causal relationships between cannabinoid-psychotropic drug interactions and adverse events. Data extracted included age, sex, psychotropic drug, cannabinoid products, other medications, and the clinical outcomes and mechanisms of these interactions.ResultsCannabinoids were involved in 8% of adverse events associated with the concomitant use of psychotropic drugs and other preparations. We identified 20 reports in which side effects presented a causal relationship with the use of psychotropic drugs and cannabinoids. Preparations containing 18% or more tetrahydrocannabinol (THC), presented significant side effects with the following antidepressants: mianserine (restless legs syndrome, urogenital pain, ventricular tachycardia), mirtazapine (pancreatitis, hyperhidrosis, arthralgia), quetiapine (myocarditis, renal failure, bradycardia, sialorrhea), haloperidol (ventricular arrhythmia, prolonged QTc), aripiprazole (prolonged QTc), ventricular tachycardia) and cariprazine (stomach pain, hepatotoxicity), sertraline (ataxia, hyperactivity, coma, hallucinations, anxiety, agitation, tachycardia, panic attacks, disorientation, headache, dizziness, blurry vision, severe emesis, xerostomia, dry eyes), trazodone (disorientation, memory impairment, sedation), fluvoxamine (tachycardia, tachypnoea, dysarthria, auditory hallucinations). Two out of 20 reports (10%) analyzed in our study was related with the simultaneous use of cannabidiol (CBD) oil and sertraline. Concomitant use of those substances was associated with the adverse events in form of diarrhea, emesis, fever and severe fatigue.ConclusionClinicians need to closely monitor adverse events resulting from the combined use of cannabinoids and psychotropic medications. The accumulation of side effects and pharmacokinetic interactions (including CYP and p-glycoprotein inhibition) between these drugs can lead to clinically significant adverse outcomes.
Effects of hyperbaric oxygen therapy on recovery after a football match in young players: a double-blind randomized controlled trial
Authors: Gušić Marko , Stantić Tomislav , Lazić Anja , Andrašić Slobodan , Roelands Bart , Bogataj Špela 
Published: October 2024

IntroductionFootball is a physically demanding sport that requires effective recovery strategies to maintain performance level and prevent injuries. This study investigated if a single 1-h hyperbaric oxygen therapy (HBOT) session affects recovery and performance after a football match in elite youth players.MethodsTwenty elite youth football players (age 17.3 ± 0.5 years) were randomly assigned to a HBOT group or a control group (CON). They played a 90-min football game and underwent either a 60-min HBOT or placebo intervention. Before (T1), at the end of the match (T2), 1 h after HBOT or CON session (T3), and 12 h after HBOT session (T4), subjects underwent biochemical (serum samples (myoglobin (MB), creatine kinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) and performance measurements (linear speed at 5 m, 10 m and 20 m, squat jump (SJ), countermovement jump (CMJ) and countermovement jump with arm swing (CMJa)). The Hooper Index (HI) was collected and heart rate was measured during the game.ResultsThe football match induced significant increases in all biochemical markers, but no significant differences were found between the HBOT and control group in biochemical or performance parameters at any time point. However, there was a significant interaction effect between time and group for HI (p = 0.012, η2 = 0.124), with the HBOT group showing significantly lower HI values (8.6 ± 2.41) than the control group (11.0 ± 3.23) at 1 h post-HBOT.DiscussionA single 1-h session of HBOT did not significantly affect recovery or performance parameters in elite youth football players, though it did show a moderate positive affect on the HI at 1 h post-HBOT. Further studies should explore the impact of either longer or sequential HBOT sessions on recovery.
Analyzing the distribution patterns and dynamic niche of Magnolia grandiflora L. in the United States and China in response to climate change
Authors: Zhang Wenqian , Wang Xinshuai , Shen Shouyun , Zhao Yanghui , Hao Siwen , Jiang Jinghuan , Zhang Donglin 
Published: October 2024

IntroductionMagnolia grandiflora L. (southern magnolia) is native to the southeastern coastal areas of the United States, from North Carolina to eastern Texas (USDA Cold Hardiness Zone 8). It is currently widely cultivated in Zones 5-10 in the U.S. and in southern Yangtze River regions in China. Limited studies have examined the effects of climate change and human activities on the geographical distribution and adaptability of M. grandiflora during its introduction to China.MethodsWe selected 127 occurrence points in the U.S. and 87 occurrence points in China, along with 43 environmental variables, to predict suitable habitat areas for M. grandiflora using present climate data (1970-2000) and projected future climate data (2050-2070) based on a complete niche ensemble model (EM) using the Biomod2 package. We also predicted the niche change of M. grandiflora in both countries using the 'ecospat' package in R.ResultsThe ensemble models demonstrated high reliability, with an AUC of 0.993 and TSS of 0.932. Solar radiation in July, human impact index, and precipitation of the wettest month were identified as the most critical variables influencing M. grandiflora distribution. The species shows a similar trend of distribution expansion under climate change scenarios in both countries, with predicted expansions towards the northwest and northeast, and contractions in southern regions.DiscussionOur study emphasizes a practical framework for predicting suitable habitats and migration of Magnoliaceae species under climate change scenarios. These findings provide valuable insights. for species conservation, introduction, management strategies, and sustainable utilization of M. grandiflora.
Factors affecting occupational burnout in medical staff: a path analysis based on the job demands-resources perspective
Authors: Wei Zuolin , Xia Bocheng , Jiang Lingli , Zhu Huaiyi , Li Lingyan , Wang Lin , Zhao Jun , Fan Ruoxin , Wang Peng , Huang Mingjin 
Published: October 2024

ObjectiveTo assess occupational burnout conditions and work-related factors among frontline medical staff during the COVID-19 pandemic and analyse the relationships among these factors utilizing the job demands–resources (JD-R) model as a theoretical framework.MethodsAn online survey was distributed to medical staff in one city via convenience sampling during 12/29/2022–1/10/2023. Path analysis was utilized to explore the relationship between work-related factors and occupational burnout among frontline medical staff during the COVID-19 outbreak.ResultsAmong 474 respondents, 455 frontline medical staff (female=79.56%) were included in the final analysis. Medical staff aged &lt;35 exhibited higher levels of occupational burnout than did older staff. Depression/anxiety and workload were positively correlated with occupational burnout and negatively correlated with self-compassion, workplace health/safety, and workplace support. Path analysis indicated the direct effects of workplace support, depression/anxiety, workplace health/safety, self-compassion, and workload on occupational burnout. There were also partial mediating effects of workplace support, depression/anxiety, workplace health/safety, and self-compassion on occupational burnout. The model demonstrated good fit.ConclusionWorkplace support, a crucial job resource, can improve occupational burnout among frontline medical staff in various ways. Reducing anxiety, depression, and workload and improving workplace support, health/safety, and self-compassion are practical and effective measures for mitigating occupational burnout.
Validation of a brief image elicitation task as an indicator of subjective wellbeing in the general population
Authors: Pincus J. David 
Published: October 2024

BackgroundA novel image-based method (AgileBrain) demonstrates construct validity as a measure of wellbeing in the general working adult population.MethodAnalysis of data from four large nationally representative samples of American full-time workers employed by mid-to-large size companies conducted in November 2021 (n = 812), May 2022 (n = 810), June 2023 (n = 986), and January 2024 (n = 1,179).ResultsAcross all four studies, AgileBrain demonstrates convergent validity across multiple established indicators of subjective wellbeing including the Patient Health Questionnaire (PHQ-9), Center for Epidemiological Studies Depression Scale (CESD-10), Generalized Anxiety Disorder Scale (GAD-7), Neuroticism (BFI-S), UCLA Loneliness Scale, Perceived Stress Scale (PSS-10), Coping Styles (Brief COPE-28), self-reported diagnosed neurodiversity conditions and symptoms, and trauma history.ConclusionResults across these studies suggest that AgileBrain is useful as a screening tool for detecting compromised wellbeing in terms of construct validity. Given strong preferences for brief, gamified assessments, the validity advantages stemming from less consciously controllable responses, and the statistical advantages of measures associated with high response rates and normal distributions, AgileBrain emerges as strong tool for assessing subjective wellbeing at the population level and offers a promising approach to monitoring treatment effectiveness.
Navigating Communication in Nursing Homes During COVID-19: Perspectives From Families, Healthcare Professionals, and Managers in Southern Switzerland—A Qualitative Study
Authors: Bernardi Sheila , Fiordelli Maddalena , Rubinelli Sara , Spagnoli Viviana , Malacrida Roberto , Martignoni Graziano 
Published: October 2024

ObjectivesThis study aims to understand the effectiveness and challenges of communication strategies implemented to maintain contact between nursing home (NH) residents and their families during the COVID-19 pandemic, by considering the perspectives of families, healthcare professionals, and NH managers.MethodsUsing a qualitative research design, the study analyzed in-depth semi-structured interviews with key stakeholders (N = 34), including family members, NH staff, and managers.ResultsThe study found that communication strategies like video calls, telephone calls, and window visits were generally appreciated and facilitated contact between residents and their families. However, challenges emerged around technical and organizational issues. Both internal and external stakeholders concurred that an increase in technological and human resources was necessary to alleviate these challenges.ConclusionThe study underscores the importance of innovative and flexible communication strategies to sustain connections between NH residents and their families in crises such as the COVID-19 pandemic. Future readiness calls for increased investment in human and technical resources, and a commitment to understanding and addressing the diverse communication needs of NH residents.
Endometriosis, a novel treatment ahead?
Authors: Marques Antônio José , Antunes Priscila de Alvarenga , Jordão Christianne de Mattos Marques , Nascimento Bruno Kappel , Antunes Carla Valéria de Alvarenga 
Published: October 2024

Endometriosis is an estrogen-dependent condition that can lead to significant morbidity, including chronic pelvic pain, multiple surgeries, and infertility. Recent discoveries regarding its genetics, the potential influence of environmental factors and the immune system, along with intrinsic abnormalities in the endometrium of affected women and the secretions from endometriotic lesions, have provided new insights into the disease's pathogenesis. These findings form the basis for developing new treatments aimed at managing disease-related pain and infertility. It was possible to observe a case of remission of symptoms and complete disappearance of lesions on ultrasound images after anthroposophic treatment. Certainly, more cases need to be followed up in the long term to verify whether there has been a real cure for the disease. Case: Brazilian woman in the reproductive period with endometriosis presented remission of symptoms with disappearance of the lesions after anthroposophic treatment
Особенности проявления никтурии и ноктурии у детей: тактика педиатра (обзор литературы)
Authors: Гусева Н.Б. , Крапивкин А.И. , Никитин С.С. , Морозов С.Л. , Колодяжная А.В. , Кононова С.А. 
Published: October 2024

Особый акцент на энурезе как проявлении коморбидной патологии у детей около 20 лет назад сделал один из основоположников детской урологии в нашей стране профессор Вишневский Е.Л. Международное сообщество специалистов по проблемам удержания мочи у детей – ICCS – долгое время позиционировало энурез только как моносимптомную патологию. Но лишь наличие жалоб на однократные и более частые пробуждения по поводу позывов к мочеиспусканию, по мнению западных экспертов, является предпосылкой к более широкому взгляду на проблему энуреза у детей. Между тем отечественные специалисты на сегодняшний день более глубоко оценивают проблему наличия мочеиспусканий с пробуждением или без него у детей в ночное время. Трактовка и выявление патологических состояний ноктурии и никтурии у детей являются неотложной частью работы педиатра. Выявление хронических заболеваний у детей разного возраста для более эффективной коррекции с привлечением профильных специалистов проводится педиатром при любом об- ращении пациентов.
Particular emphasis on enuresis, as a manifestation of comorbid pathology in children, was made about 20 years ago by one of the founders of pediatric urology in our country, Professor E.L. Vishnevsky. The international community of specialists in the problems of incontinence in children, ICCS, has long positioned enuresis only as a monosymptomatic pathology. But only, the presence of complaints of single and more frequent awakenings due to the urge to urinate, according to Western experts, is an indication for a broader view of the problem of enuresis in children. Meanwhile, domestic experts today more deeply assess the presence of incontinence with or without awakening in children at night. Interpretation and identification of such pathological conditions as nycturia and nocturia in children is an urgent part of the pediatrician’s work in identifying chronic diseases in children of different ages for more effective correction with the involvement of specialized specialists.
Impact of investments in mining on economic growth of Krasnoyarsk Krai
Authors: Kharitonova M. Yu. , Matsko N. A. 
Published: October 2024

Aim. To evaluate the impact of investments in mineral extraction on the economic growth of Krasnoyarsk Krai using the dynamics of data for 2004–2021.Objectives. To prepare initial data for modeling in comparable prices; to build statistical models with a time lag; to determine the multiplier and gas pedal coefficients of investment; to demonstrate the possibilities of applying the obtained dependencies.Methods. The authors used the method of economic and mathematical modeling, in particular the calculation of socio-economic indicators using mathematical statistics. The regression model was built using the initial data that meet the requirements of comparability and homogeneity, are relevant and statistically reliable.Results. Dependencies reflecting the investment multiplier effect, i.e. the increase in the gross regional product (GRP) and the volume of shipped products in response to the increase in investment in mining were obtained. Dependencies reflecting the investment gas pedal effect are also obtained, showing how increased income affects the size of investment. The dependencies are applied to solve a number of practical problems.Conclusions. It has been established that investments in mining in Krasnoyarsk Krai have an impact on the growth of GRP and the volume of shipped products. The return on investment has a temporary character. The strongest impact of investments in the current year have on the growth of GRP and shipped products for the next year. The multiplier coefficient is 2.72. Increased income affects the size of investments: the growth of income from mining stimulates the growth of induced investments in the following year with the multiplier coefficient, which is equal to 0.14. The comparison of actual values of investments in mineral resources extraction and volume of shipped products with the target values laid down in the Strategy of socioeconomic development of the region until 2030 has been carried out. The target values, according to the Strategy, are determined with the help of the obtained dependencies. It was established that the actual volume of investments is sufficient to ensure the GRP growth in accordance with the Strategy at the first stage; to ensure growth at the second stage it is necessary to increase investments by 12–15 % annually; to ensure growth at the third stage it is necessary to increase investments by 9–13 % annually from the current state. In order to ensure the values of indicators on the volume of production provided for in the Strategy, it is necessary to increase output by 4–6 % annually compared to 2021.
Technological sovereignty as a factor of competitiveness of oil and gas companies of the Russian Federation
Authors: Gorbashko E. A. , Borodin V. I. 
Published: October 2024

Aim. To investigate the importance of technological sovereignty for strengthening the competitive positions of Russian oil and gas companies.Objectives. To identify the key factors that determine the level of technological independence of oil and gas companies; to assess how these factors affect their ability to compete successfully at the national and international levels.Methodology. The research uses general scientific methods of analysis and synthesis using a systematic approach.Results. The essence of technological independence as a factor in the development of competitiveness of companies in the oil and gas sector was analyzed. The assumption is formulated that the achievement of technological sovereignty allows companies to mitigate risks arising from external factors, including international sanctions and restrictions on access to advanced foreign technologies. Several strategic initiatives have been proposed to strengthen the technological sovereignty of the domestic oil and gas industry: training of highly qualified personnel, introduction of tax incentives and subsidies from the state for companies, creation of special economic zones or technology parks, protection of intellectual property and support for patent activity.Conclusions. Technological independence is the most effective method in the context of the struggle of Russian industrial companies against external challenges: sanctions and changes in global energy markets. The development of national technologies in the oil and gas sector due to the synergetic effect has a positive impact on strengthening the competitive advantages of Russian national companies in both domestic and international markets. In order to ensure technological sovereignty, special attention should be paid to the development of strategic risk management mechanisms, as well as effective communication models between the state, industry, and science.