bluuebunny/crossref_metadata_2025_split huggingface dataset:
Christ Was Not an Inerrantist, so Christians
Should Not Be Either: How Jesus Read His
Bible
Authors: Sydnor Jon Paul 
Published: August 2016

Abstract
Jesus’ interpretation of the Hebrew scriptures is skillfully eclectic, employing techniques of
rejection, interiorization, prioritization, and synthesis. The eclectic nature of Christ’s interpretation of
the Hebrew scriptures specifically precludes any ascription of the contemporary strategies of rigorism or
inerrantism to his hermeneutic. Instead, Christ’s hermeneutic is best described as situational, agapic, and
open—hence pastoral. It is situational insofar as no hermeneutical rule can predetermine how scripture
will be applied to a situation. It is agapic insofar as all texts are interpreted in service of the divine
love and repaired human relationship. It is open insofar as it: 1. is characterized by bricolage, hence
open to experimentation with a variety of resources, 2. resists any rigidly predetermined interpretative
outcome, thereby preserving openness to agapic outcomes, 3. valorizes the micronarrative, and 4. rejects
totalization. Ultimately, Jesus’ interpretation of scripture is pastoral, preferring human flourishing
through scripture to blind obedience of scripture.
Excessive Sensory Stimulation during Development Alters Neural Plasticity and Vulnerability to Cocaine in Mice
Authors: Ravinder Shilpa , Donckels Elizabeth A. , Ramirez Julian S. B. , Christakis Dimitri A. , Ramirez Jan-Marino , Ferguson Susan M. 
Published: August 2016

AbstractEarly life experiences affect the formation of neuronal networks, which can have a profound impact on brain function and behavior later in life. Previous work has shown that mice exposed to excessive sensory stimulation during development are hyperactive and novelty seeking, and display impaired cognition compared with controls. In this study, we addressed the issue of whether excessive sensory stimulation during development could alter behaviors related to addiction and underlying circuitry in CD-1 mice. We found that the reinforcing properties of cocaine were significantly enhanced in mice exposed to excessive sensory stimulation. Moreover, although these mice displayed hyperactivity that became more pronounced over time, they showed impaired persistence of cocaine-induced locomotor sensitization. These behavioral effects were associated with alterations in glutamatergic transmission in the nucleus accumbens and amygdala. Together, these findings suggest that excessive sensory stimulation in early life significantly alters drug reward and the neural circuits that regulate addiction and attention deficit hyperactivity. These observations highlight the consequences of early life experiences and may have important implications for children growing up in today’s complex technological environment.
Genetic Architecture of Resistance to Stripe Rust in a Global Winter Wheat Germplasm Collection
Authors: Bulli Peter , Zhang Junli , Chao Shiaoman , Chen Xianming , Pumphrey Michael 
Published: August 2016

AbstractVirulence shifts in populations of Puccinia striiformis f. sp. tritici (Pst), the causal pathogen of wheat stripe rust, are a major challenge to resistance breeding. The majority of known resistance genes are already ineffective against current races of Pst, necessitating the identification and introgression of new sources of resistance. Germplasm core collections that reflect the range of genetic and phenotypic diversity of crop species are ideal platforms for examining the genetic architecture of complex traits such as resistance to stripe rust. We report the results of genetic characterization and genome-wide association analysis (GWAS) for resistance to stripe rust in a core subset of 1175 accessions in the National Small Grains Collection (NSGC) winter wheat germplasm collection, based on genotyping with the wheat 9K single nucleotide polymorphism (SNP) iSelect assay and phenotyping of seedling and adult plants under natural disease epidemics in four environments. High correlations among the field data translated into high heritability values within and across locations. Population structure was evident when accessions were grouped by stripe rust reaction. GWAS identified 127 resistance loci that were effective across at least two environments, including 20 with significant genome-wide adjusted P-values. Based on relative map positions of previously reported genes and QTL, five of the QTL with significant genome-wide adjusted P-values in this study represent potentially new loci. This study provides an overview of the diversity of Pst resistance in the NSGC winter wheat germplasm core collection, which can be exploited for diversification of stripe rust resistance in breeding programs.
The Use of Targeted Marker Subsets to Account for Population Structure and Relatedness in Genome-Wide Association Studies of Maize (Zea maysL.)
Authors: Chen Angela H , Lipka Alexander E 
Published: August 2016

AbstractA typical plant genome-wide association study (GWAS) uses a mixed linear model (MLM) that includes a trait as the response variable, a marker as an explanatory variable, and fixed and random effect covariates accounting for population structure and relatedness. Although effective in controlling for false positive signals, this model typically fails to detect signals that are correlated with population structure or are located in high linkage disequilibrium (LD) genomic regions. This result likely arises from each tested marker being used to estimate population structure and relatedness. Previous work has demonstrated that it is possible to increase the power of the MLM by estimating relatedness (i.e., kinship) with markers that are not located on the chromosome where the tested marker resides. To quantify the amount of additional significant signals one can expect using this so-called K_chr model, we reanalyzed Mendelian, polygenic, and complex traits in two maize (Zea mays L.) diversity panels that have been previously assessed using the traditional MLM. We demonstrated that the K_chr model could find more significant associations, especially in high LD regions. This finding is underscored by our identification of novel genomic signals proximal to the tocochromanol biosynthetic pathway gene ZmVTE1 that are associated with a ratio of tocotrienols. We conclude that the K_chr model can detect more intricate sources of allelic variation underlying agronomically important traits, and should therefore become more widely used for GWAS. To facilitate the implementation of the K_chr model, we provide code written in the R programming language.
A Genomic Bayesian Multi-trait and Multi-environment Model
Authors: Montesinos-López Osval A , Montesinos-López Abelardo , Crossa José , Toledo Fernando H , Pérez-Hernández Oscar , Eskridge Kent M , Rutkoski Jessica 
Published: August 2016

AbstractWhen information on multiple genotypes evaluated in multiple environments is recorded, a multi-environment single trait model for assessing genotype × environment interaction (G × E) is usually employed. Comprehensive models that simultaneously take into account the correlated traits and trait × genotype × environment interaction (T × G × E) are lacking. In this research, we propose a Bayesian model for analyzing multiple traits and multiple environments for whole-genome prediction (WGP) model. For this model, we used Half-t priors on each standard deviation term and uniform priors on each correlation of the covariance matrix. These priors were not informative and led to posterior inferences that were insensitive to the choice of hyper-parameters. We also developed a computationally efficient Markov Chain Monte Carlo (MCMC) under the above priors, which allowed us to obtain all required full conditional distributions of the parameters leading to an exact Gibbs sampling for the posterior distribution. We used two real data sets to implement and evaluate the proposed Bayesian method and found that when the correlation between traits was high (&gt;0.5), the proposed model (with unstructured variance–covariance) improved prediction accuracy compared to the model with diagonal and standard variance–covariance structures. The R-software package Bayesian Multi-Trait and Multi-Environment (BMTME) offers optimized C++ routines to efficiently perform the analyses.
Navigating the Phenotype Frontier: The Monarch Initiative
Authors: McMurry Julie A , Köhler Sebastian , Washington Nicole L , Balhoff James P , Borromeo Charles , Brush Matthew , Carbon Seth , Conlin Tom , Dunn Nathan , Engelstad Mark , Foster Erin , Gourdine Jean-Philippe , Jacobsen Julius OB , Keith Daniel , Laraway Bryan , Xuan Jeremy Nguyen , Shefchek Kent , Vasilevsky Nicole A , Yuan Zhou , Lewis Suzanna E , Hochheiser Harry , Groza Tudor , Smedley Damian , Robinson Peter N , Mungall Christopher J , Haendel Melissa A 
Published: August 2016

AbstractThe principles of genetics apply across the entire tree of life. At the cellular level we share biological mechanisms with species from which we diverged millions, even billions of years ago. We can exploit this common ancestry to learn about health and disease, by analyzing DNA and protein sequences, but also through the observable outcomes of genetic differences, i.e. phenotypes. To solve challenging disease problems we need to unify the heterogeneous data that relates genomics to disease traits. Without a big-picture view of phenotypic data, many questions in genetics are difficult or impossible to answer. The Monarch Initiative (https://monarchinitiative.org) provides tools for genotype-phenotype analysis, genomic diagnostics, and precision medicine across broad areas of disease.
Development and Validation of a Method to Identify Children With Social Complexity Risk Factors
Authors: Schrager Sheree M. , Arthur Kimberly C. , Nelson Justine , Edwards Anne R. , Murphy J. Michael , Mangione-Smith Rita , Chen Alex Y. 
Published: August 2016

OBJECTIVES:
We sought to develop and validate a method to identify social complexity risk factors (eg, limited English proficiency) using Minnesota state administrative data. A secondary objective was to examine the relationship between social complexity and caregiver-reported need for care coordination.

METHODS:
A total of 460 caregivers of children with noncomplex chronic conditions enrolled in a Minnesota public health care program were surveyed and administrative data on these caregivers and children were obtained. We validated the administrative measures by examining their concordance with caregiver-reported indicators of social complexity risk factors using tetrachoric correlations. Logistic regression analyses subsequently assessed the association between social complexity risk factors identified using Minnesota’s state administrative data and caregiver-reported need for care coordination, adjusting for child demographics.

RESULTS:
Concordance between administrative and caregiver-reported data was moderate to high (correlation range 0.31–0.94, all P values &lt;.01), with only current homelessness (r = –0.01, P = .95) failing to align significantly between the data sources. The presence of any social complexity risk factor was significantly associated with need for care coordination before (unadjusted odds ratio = 1.65; 95% confidence interval, 1.07–2.53) but not after adjusting for child demographic factors (adjusted odds ratio = 1.53; 95% confidence interval, 0.98–2.37).

CONCLUSIONS:
Social complexity risk factors may be accurately obtained from state administrative data. The presence of these risk factors may heighten a family’s need for care coordination and/or other services for children with chronic illness, even those not considered medically complex.
The PSC-17: Subscale Scores, Reliability, and Factor Structure in a New National Sample
Authors: Murphy J. Michael , Bergmann Paul , Chiang Cindy , Sturner Raymond , Howard Barbara , Abel Madelaine R. , Jellinek Michael 
Published: August 2016

BACKGROUND:
The Pediatric Symptom Checklist-17 (PSC-17) is a widely used, briefer version of the PSC-35, a parent-completed measure of children’s psychosocial functioning. Despite the extensive use of the PSC-17 over the past 15 years there has not been a large-scale replication of the original derivation study.

OBJECTIVE:
To examine the prevalence of positive screens, reliability, and factor structure of PSC-17 scores in a new national sample and compare them with the derivation sample.

METHODS:
Data were collected on 80 680 pediatric outpatients, ages 4 to 15 years, whose parents filled out the PSC-17 from 2006 to 2015 via the Child Health and Development Interactive System, an electronic system that presents and scores clinical measures.

RESULTS:
The rates of positive screening on the overall PSC-17 (11.6%) and on the internalizing (10.4%) and attention (9.1%) subscales were comparable to rates found in the original sample, although the rate of externalizing problems (10.2%) was lower than in the derivation study. Reliability was high (internal consistency 0.89; test–retest 0.85), and a confirmatory factor analysis provided support for the original 3-factor model.

CONCLUSIONS:
Fifteen years after the PSC-17 was derived in a large nationally representative outpatient pediatric sample, a new and larger national sample found rates of positive screening, reliability, and factor structure that were comparable. Findings from this study support the continued use of the PSC-17 clinically as a screening tool in pediatric settings and in research.
Sleep Outcomes in Children with Single-Suture Craniosynostosis Compared with Unaffected Controls
Authors: Sun Baiyang , Cloonan Yona K. , Collett Brent R. , Speltz Matthew L. 
Published: August 2016

Objective To compare risk for sleep-disordered breathing between children with and without single-suture craniosynostosis. Participants A total of 184 children with single-suture craniosynostosis and 184 controls. Main Outcome Measures Parent reported sleep-disordered breathing-related symptoms. Results Current sleep problems were reported in 19% of patients with single-suture craniosynostosis and 14% of controls (adjusted odds ratio = 1.6; 95% CI, 0.9 to 2.8). Ever having sleep problems was reported in 25% and 23% of cases and controls, respectively (adjusted odds ratio = 1.2; 95% CI, 0.7 to 1.9). Overall, snoring was statistically associated with single-suture craniosynostosis ( P = .01) and was more often reported as 2+ nights per week (versus never) in patients with single-suture craniosynostosis (13%) than in controls (4%) (adjusted odds ratio = 3.5; 95% CI, 1.5 to 8.2). Conclusions Though preliminary, increased presence of snoring during sleep in children with single-suture craniosynostosis compared with controls suggests that children with isolated single-suture craniosynostosis may be at increased risk for sleep-disordered breathing. Further study using standardized assessments of sleep-disordered breathing is needed.
Acupuncture for Chemoradiation Therapy-Related Dysphagia in Head and Neck Cancer: A Pilot Randomized Sham-Controlled Trial
Authors: Lu Weidong , Wayne Peter M. , Davis Roger B. , Buring Julie E. , Li Hailun , Macklin Eric A. , Lorch Jochen H. , Burke Elaine , Haddad Tyler C. , Goguen Laura A. , Rosenthal David S. , Tishler Roy B. , Posner Marshall R. , Haddad Robert I. 
Published: August 2016

Abstract

Introduction.
Dysphagia is common in head and neck cancer patients after concurrent chemoradiation therapy (CRT). This study evaluated the feasibility of conducting a randomized sham-controlled trial and collected preliminary data on safety and efficacy of acupuncture.

Patients and Methods.
Head and neck cancer (HNC) patients with stage III–IV squamous cell carcinoma were randomized to 12 sessions of either active acupuncture (AA) or sham acupuncture (SA) during and following CRT. Patients were blinded to treatment assignment. Swallowing-related quality of life (QOL) was assessed using the MD Anderson Dysphagia Inventory (MDADI) total and subscale scores.

Results.
Multiple aspects of trial feasibility were confirmed. Forty-two of 196 patients screened (21%) were enrolled and randomized to receive AA (n = 21) or SA (n = 21); 79% completed at least 10 of 12 planned acupuncture sessions; 81% completed the study follow-ups. The majority of patients reported uncertainty regarding their treatment assignment, with no difference between the AA and SA groups. Audits confirmed both AA and SA treatments were delivered with high fidelity. No serious acupuncture-related side effects were observed. MDADI total scores significantly improved from baseline to 12 months post-CRT in both groups (AA: +7.9; SA +13.9; p = .044, p &lt; .001). Similar patterns were observed for the MDADI global subscale (AA: +25.0; SA +22.7; p = .001, p = .002). Intent-to-treat analyses suggested no difference between the treatment groups (p = .17, p = .76 for MDADI total and global scores, respectively).

Conclusion.
A sham-controlled randomized trial evaluating acupuncture in dysphagia-related QOL in HNC found the procedure to be feasible and safe. Further investigation is required to evaluate efficacy.
Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma
Authors: Lacouture Mario E. , Dréno Brigitte , Ascierto Paolo Antonio , Dummer Reinhard , Basset-Seguin Nicole , Fife Kate , Ernst Scott , Licitra Lisa , Neves Rogerio I. , Peris Ketty , Puig Susana , Sokolof Jonas , Sekulic Aleksandar , Hauschild Axel , Kunstfeld Rainer 
Published: August 2016

AbstractAbnormal activation of hedgehog pathway signaling is a key driver in the pathogenesis of basal cell carcinoma (BCC). Vismodegib, a first-in-class small-molecule inhibitor of hedgehog pathway signaling, is approved by regulatory authorities for the treatment of adults who have metastatic BCC or locally advanced BCC that has recurred after surgery, or who are not candidates for surgery and who are not candidates for radiation. A second inhibitor, sonidegib, was also recently approved for the same patient group with locally advanced BCC. Adverse events (AEs) commonly observed in hedgehog pathway inhibitor (HPI)-treated patients include muscle spasms, ageusia/dysgeusia, alopecia, weight loss, and asthenia (fatigue). These AEs are thought to be mechanistically related to inhibition of the hedgehog pathway in normal tissue. Although the severity of the majority of AEs associated with HPIs is grade 1–2, the long-term nature of these AEs can lead to decreased quality of life, treatment interruption, and in some cases discontinuation, all of which might affect clinical outcome. The incidence, clinical presentation, putative mechanisms, and management strategies for AEs related to HPIs in advanced BCC are described. These observations represent the first step toward the development of mechanism-based preventive and management strategies. Knowledge of these AEs will allow health care professionals to provide appropriate counseling and supportive care interventions, all of which will contribute to improved quality of life and optimal benefit from therapy.
CONTRIBUIÇÕES TEÓRICAS PARA COMPREENDER E AMAR A CRIANÇA
Authors: Valença Vera Lúcia Chacon , Simiano Maristela Pandini 
Published: August 2016

O propósito deste artigo é apresentar algumas contribuições a respeito da criança e da infância a partir da compreensão de especialistas, tais como Francesco Tonucci, Gilles Brougère, Wiliam Corsaro, Janusz Korczak, Alain Renaut, Clarice Cohn, entre outros. Uma revisão teórica não exaustiva permitiu a busca de pontos de proximidades/distanciamentos entre esses autores de diversos campos disciplinares que utilizam/utilizaram, em suas investigações, observações de crianças em diferentes espaços: pátios de escola, cidades, aldeias, etc. Eles concordam com a existência de uma criança ativo-participativa, real, existente no presente. Ressaltam a influência do contexto cultural como um dos determinantes fundamentais da socialização, apresentam conceitos diferentes, inclusive sobre cultura, e também atribuem significados distintos a termos aparentemente semelhantes.
Lumbar Posterior Apophyseal Ring Fracture Combined with Spondylolysis in Pediatric Athletes
Authors: Tamaki Shunsuke , Yamashita Kazuta , Higashino Kosaku , Sakai Toshinori , Takata Yoichiro , Sairyo Koichi 
Published: August 2016

Case:
Lumbar posterior apophyseal ring fracture is an uncommon finding in children, but lumbar spondylolysis is a common disorder. Both disorders are prevalent in young athletes. We describe 3 adolescent athletes who showed both lumbar spondylolysis and lumbar posterior apophyseal ring fracture. Because lumbar spondylolysis is comparatively easy to diagnose, a concurrent posterior lumbar apophyseal ring fracture is likely to be overlooked.

Conclusion:
In patients with severe low back and radicular pain in whom spondylolysis is suspected, it is important to perform not only magnetic resonance imaging and radiography but also computed tomography for identifying posterior apophyseal ring fractures.
Experimental Investigation on Brazilian Tensile Strength of Organic-Rich Gas Shale
Authors: Li Hui , Lai Bitao , Liu Hui-Hai , Zhang Jilin , Georgi Daniel 
Published: August 2016

SummaryTensile strength is a critical parameter for hydraulic fracturing, predicting fracture initiation and propagation in reservoirs, especially in shale reservoirs with complex natural fractures and fissures. The tensile strength of conventional rocks, such as sandstone and limestone, has been well-studied and -documented. There are many studies of the tensile strength of laminated shale, which focus on scale effects, loading direction, and temperature effects; however, the studies on effects of mineralogy and the water content on tensile strength of organic-rich shales are very limited.The objectives of this paper are to (1) critically review the key parameters that affect the tensile strength of shale and 2) experimentally examine the effects of water content, mineralogy, and lamination on tensile strength. To do so, a rigorous workflow is followed: 1) Each 1-in.-long shale sample is cut into two subsamples, A and B, of similar length; (2) X-ray computed-tomography (CT) scan is performed to diagnose pre-existing cracks and defects inside the core plugs; (3) nuclear magnetic resonance (NMR) is then used to measure the air dry samples’ water content; (4) Sample A is placed on a load frame to measure the tensile strength; (5) Sample B is vacuumed and then saturated; (6) NMR is used to measure the water content after saturation; (7) tensile strength of the saturated Sample B is measured; and (8) after the sample fails, the pieces are used for X-ray diffraction (XRD), scanning electron microscopy (SEM), and pyrolysis to estimate the mineralogy and total organic content (TOC).A total of 70 Mancos and 48 Eagle Ford shale samples have been tested. The experimental results show that (1) bedding plane/lamination has a significant effect on Eagle Ford tensile strength, but no pronounced impact is observed for the Mancos shale; (2) the imbibed water significantly reduces the tensile strength by 4.4 to 51.7% as water content increases from 4.45 to 11.7%; (3) pre-existing detectable microfractures can significantly reduce the tensile strength by up to 66%; (4) Eagle Ford exhibits typical brittle hard-rock failure configuration, with primary fractures and secondary fractures being observed, whereas for the Mancos shale, only primary fractures are observed; (5) acoustic velocity-test results confirm that Eagle Ford is mechanically transversely isotropic, and Mancos is likely mechanically isotropic.