bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antenatal dietary patterns and depressive symptoms during pregnancy and early post‐partum
Authors: Baskin Rachel , Hill Briony , Jacka Felice N , O'Neil Adrienne , Skouteris Helen 
Published: January 2016

AbstractPerinatal depression is a debilitating disorder experienced during pregnancy and/or the first year post‐partum. Recently, maternal dietary intake during pregnancy has emerged as a possible area of intervention for the prevention of mental disorders in women and their offspring. However, the relationship between antenatal diet quality and perinatal depressive symptoms remains poorly understood. The current study explored the predictive role of antenatal diet quality for antenatal and post‐natal depressive symptoms. Pregnant women (n = 167) were recruited between February 2010 and December 2011. Women completed the Edinburgh Postnatal Depression Scale at time 1 [T1, mean weeks gestation = 16.70, standard deviation (SD) = 0.91], time 2 (T2, mean weeks gestation = 32.89, SD = 0.89) and time 3 (T3, mean weeks post‐partum = 13.51, SD = 1.97) and a food frequency questionnaire at T1 and T2. Diet quality was determined by extracting dietary patterns via principal components analysis. Two dietary patterns were identified: ‘healthy’ (including fruit, vegetables, fish and whole grains) and ‘unhealthy’ (including sweets, refined grains, high‐energy drinks and fast foods). Associations between dietary patterns and depressive symptoms were investigated by path analyses. While both ‘healthy’ and ‘unhealthy’ path models showed good fit, only one significant association consistent with study hypotheses was found, an ‘unhealthy’ diet was associated with increased depressive symptoms at 32 weeks gestation. Given that this association was cross‐sectional, it was not possible to make any firm conclusions about the predictive nature of either dietary patterns or depressive symptoms. Dietary intervention studies or larger prospective studies are therefore recommended.
Genetic mapping and inheritance of Russian wheat aphid resistance gene in accession IG 100695
Authors: Aykut Tonk Fatma , İştipliler Deniz , Tosun Muzaffer , Turanli Ferit , İlbi Hülya , Çakir Mehmet 
Published: January 2016

AbstractThe Russian wheat aphid (RWA), Diuraphis noxia (Kurdjumov), is an important pest of small‐grain cereals, particularly wheat, worldwide. The most efficient strategy against the RWA is to identify sources of resistance and to introduce them into susceptible wheat genotypes. This study was conducted to determine the mode of inheritance of the RWA resistance found in ICARDA accession IG 100695, to identify wheat microsatellite markers closely linked to the gene and to map the chromosomal location of the gene. Simple sequence repeat (SSR) marker scores were identified in a mapping population of 190 F2 individuals and compared, while phenotypic screening for resistance was performed in F2 : 3 families derived from a cross between ‘Basribey’ (susceptible) and IG 100695 (resistant). Phenotypic segregation of leaf chlorosis and rolling displayed the effect of a single dominant gene, temporarily denoted Dn100695, in IG 100695. Dn100695 was mapped on the short arm of chromosome 7D with four linked SSR markers, Xgwm44, Xcfd14, Xcfd46 and Xbarc126. Dn100695 and linked SSR markers may be useful for improving resistance for RWA in wheat breeding.
The use of plant stress biomarkers in assessing the effects of desiccation in zygotic embryos from recalcitrant seeds: challenges and considerations
Authors: Sershen  , Varghese B. , Naidoo C. , Pammenter N.W. 
Published: January 2016

AbstractZygotic embryos from recalcitrant seeds are sensitive to desiccation. In spite of their sensitivity, rapid partial dehydration is necessary for their successful cryopreservation. However, dehydration to water contents (WCs) that preclude lethal ice crystal formation during cooling and rewarming generally leads to desiccation damage. This study investigated the effects of rapid dehydration on selected stress biomarkers (electrolyte leakage, respiratory competence, rate of protein synthesis, superoxide production, lipid peroxidation, antioxidant activity and degree of cellular vacuolation) in zygotic embryos of four recalcitrant‐seeded species. Most biomarkers indicated differences in the levels of stress/damage incurred by embryos dried to WCs < and >0.4 g·g−1, within species; however, these changes were often unrelated to viability and percentage water loss when data for the four species were pooled for regression analyses. Dehydration‐induced electrolyte leakage was, however, positively related with percentage water loss, while biomarkers of cellular vacuolation were positively related with both percentage water loss and viability. This suggests that electrolyte leakage and degree of cellular vacuolation can be used to quantify dehydration‐induced stress/damage. Biomarkers such as superoxide production, whilst useful in establishing the nature of the dehydration stress incurred may not be able to distinguish the effects of different WCs/drying times. Irrespective of which biomarker is used, the data suggest that understanding differences in desiccation sensitivity across recalcitrant‐seeded species will remain a challenge unless these biomarkers are related to a generic desiccation stress index that integrates the effects of percentage water loss and drying time.
Public Service Motivation: A Systematic Literature Review and Outlook
Authors: Ritz Adrian , Brewer Gene A. , Neumann Oliver 
Published: January 2016

AbstractOver the past two decades, research on public service motivation has seen rapid growth. Despite the relatively large number of publications to date, no systematic research overview has been created, leaving the body of literature somewhat unstructured and possibly hampering future research. This article fills this void by providing a systematic literature review of 323 publications that examines six key aspects of the literature on public service motivation: the growth of research on the concept, the most prominent studies based on a referencing network analysis, the most frequent publication outlets, research designs and methods, lines of inquiry and patterns of empirical findings, and implications for practice drawn from the publications in the study sample. Strengths and weaknesses of the existing literature are identified, and future research directions are proposed.
The Domestic Use of Drones: An Ethical Analysis of Surveillance Issues
Authors: West Jonathan P. , Bowman James S. 
Published: January 2016

AbstractDrone surveillance can be regarded either as a justifiable, impartial practice serving the interests of all or as an oppressive technique catering to the interests of some at the expense of others. This analysis is an effort to weigh the ethical prospects and problems in the use of unmanned aerial vehicles by asking whether surveillance of civilians is ethical. To address this question, classical philosophical and modern behavioral approaches to ethics are used. The inquiry begins with the importance of the issue, followed by its evolution and current status. After describing the method of analysis, the article examines arguments for and against domestic monitoring. The unique utility of drones can accomplish much in the public interest while simultaneously creating moral hazards. The conclusion discusses accountability standards, model legislation provisions, and regulatory criteria for aerial vehicle surveillance.
Public Information and Regulatory Processes: What the Public Knows and Regulators Decide
Authors: Crow Deserai A. , Albright Elizabeth A. , Koebele Elizabeth 
Published: January 2016

AbstractBecause bureaucratic agencies may be less transparent in their decision processes than legislatures, most states have developed processes to incorporate input from regulated communities and other parties potentially affected by regulations. Administrative agencies may encourage democratic practices to increase legitimacy and accountability of the bureaucracy and improve decision‐making processes. However, rules governing the regulatory process vary by state, with some incorporating more open practices than others. Understanding these dynamics is increasingly important, as the rulemaking process has become central to policymaking over the past several decades, with a large portion of policymaking authority delegated to administrative agencies. Drawing from regulatory documents, rulemaking comments, media coverage, and interviews with regulators in 14 regulatory decision processes across five states, this study finds that while states vary in their approach to providing access to information, there are overriding patterns that reduce the role of citizens and the overall transparency of regulatory processes.
Why Do Regulatory Agencies Punish? The Impact of Political Principals, Agency Culture, and Transaction Costs in Predicting Environmental Criminal Prosecution Outcomes in the United States
Authors: Ozymy Joshua , Jarrell Melissa 
Published: January 2016

AbstractStudies of administrative behavior are keen to examine the internal dynamics of agency decision making, as well the impact of external political actors on agency actions. Yet few studies apply these findings to the question of why agencies use their most punitive enforcement powers. Contrasting principal–agent, transaction costs, and organizational culture models of agency behavior, this study examines why regulatory agencies punish. Through content analysis of nearly one thousand of the U.S. Environmental Protection Agency's criminal investigations and subsequent prosecutions, 2001–11, findings suggest that punishment severity in environmental criminal cases is based less on transaction costs and political pressure and more on professional norms that value strong enforcement. These findings have important implications for explaining regulatory outcomes and administrative behavior.
Institutional Change Through Policy Learning: The Case of the European Commission and Research Policy
Authors: Tamtik Merli 
Published: January 2016

AbstractResearch initiatives to enhance knowledge‐based societies demand regionally coordinated policy approaches. By analyzing the case of the European Commission, Directorate‐General Research and Innovation, this study focuses on examining the cognitive mechanisms that form the foundation for institutional transformations and result in leadership positions in regional governance. Drawing on policy learning theories, the study emphasizes specific mechanisms of institutional change that are often less noticeable but can gradually lead to mobilizing diverse groups of stakeholders. Through historical and empirical data, this study shows the importance of policy learning through communication processes, Open Method of Coordination initiatives, and issue framing in creating a stronger foundation for policy coordination in European research policy since the 2000s.
Tests for High Dimensional Generalized Linear Models
Authors: Guo Bin , Chen Song Xi 
Published: January 2016

SummaryWe consider testing regression coefficients in high dimensional generalized linear models. By modifying the test statistic of Goeman and his colleagues for large but fixed dimensional settings, we propose a new test, based on an asymptotic analysis, that is applicable for diverging dimensions and is robust to accommodate a wide range of link functions. The power properties of the tests are evaluated asymptotically under two families of alternative hypotheses. In addition, a test in the presence of nuisance parameters is also proposed. The tests can provide p-values for testing significance of multiple gene sets, whose application is demonstrated in a case-study on lung cancer.
Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis
Authors: Nguyen Nghia H , Yee Brittany E , Chang Christine , Jin Minjuan , Lutchman Glen , Lim Joseph K , Nguyen Mindie H 
Published: January 2016

BackgroundOutcome data on simeprevir and sofosbuvir (SMV+SOF) in patients with liver transplantation (LT) with hepatitis C virus genotype 1 (HCV-1) are limited with individual studies having a small sample size and limited SVR12 (sustained virological response) data. Our goal was to perform a meta-analysis to study the outcome of SMV+SOF±ribavirin (RBV) in recipients with LT.MethodsIn April 2015, we conducted a literature search for ‘simeprevir’ in MEDLINE/EMBASE and five major liver meetings. We included studies with SVR12 data in ≥5 post-LT mono-infected HCV-1 patients treated with SMV+SOF±RBV. We used random-effects models to estimate effect sizes, and the Cochrane Q-test (p value <0.10) with I2(>50%) to assess study heterogeneity.ResultsWe included nine studies with a total of 325 patients with post-LT. Studies included mostly men (59–81%). Pooled SVR12 was 88.0% (95% CI 83.4% to 91.5%). In two studies, HCV-1a patients with mild fibrosis (n=108) had an SVR12 rate of 95.0% (95% CI 82.4% to 98.7%), which was significantly higher than that of HCV-1a patients with advanced fibrosis (n=49) with an SVR12 rate of 81.7% (95% CI 69.8% to 89.5%), OR 4.2 (95% CI 1.1 to 16.1, p=0.03). The most common pooled side effects were: fatigue 21% (n=48/237), headache 9% (n=23/254), dermatological symptoms 15% (n=38/254), and gastrointestinal symptoms 6% (12/193).ConclusionsSMV+SOF±RBV is safe and effective in recipients with LT with HCV-1 infection.
Prevalence of hepatitis B seromarkers and hepatitis C antibodies in blood donors in Basra, Iraq
Authors: Al-Rubaye Ali , Tariq Ziad , Alrubaiy Laith 
Published: January 2016

BackgroundTransfusion-caused hepatitis remains a major problem in Iraq. Therefore, testing for hepatitis B surface antigen (HBsAg), antibodies to hepatitis B core antigen (anti-HBc) and antibodies to hepatitis C antigen (anti-HCV) is a very important preventative measure. The objective of this study was to establish the prevalence of hepatitis B and C virus seromarkers among blood donors as a foundation for safe blood transfusion in Iraq.MethodsA cross-sectional observational study was conducted in the blood banks in Basra, Iraq from 1 January to 31 December 2013. Blood samples were collected and were tested for HBsAg, anti-HBc and anti-HCV using standard laboratory techniques.ResultsA total of 69 915 blood donors were enrolled for the study. A total of 1625 (2.3%) donors have shown serological evidence for hepatitis B virus infection; of those donors, 125 (0.2%) showed a positive test result for both anti-HBc and HBsAg while 1475 (2.1%) had positive anti-HBc results as the only positive test for HBV infection. There was no significant difference between males and females (p=0.28). The prevalence of anti-HCV was 0.1%.ConclusionsThis is the first large population study of its kind in Basra, Iraq. The prevalence of hepatitis B and C among blood donors is very low in Basra. Around 2% of blood donors had anti-HBc as the only serological evidence of HBV infection. Inclusion of anti-HBc in routine screening of blood donors in Iraq should be encouraged.
On the Power of One-Way Automata with Quantum and Classical States
Authors: Bianchi Maria Paola , Mereghetti Carlo , Palano Beatrice 
Published: January 2016

We consider the model of one-way automata with quantum and classical states (QCFAs) introduced in [28]. We show, by a direct approach, that QCFAs with isolated cut-point accept regular languages only, thus characterizing their computational power.Concerning descriptional power, we quickly overview a size lower bound for QCFAs accepting regular languages, and address its optimality. Then, we explicitly build QCFAs accepting the word quotients and inverse homomorphic images of languages accepted by given QCFAs with isolated cut-point, maintaining the same cut-point, isolation, and only polynomially increasing the size.
Ab-initio HF and density functional theory investigations on the synthesis mechanism, conformational stability, molecular structure and UV spectrum of N’-Formylkynurenine
Authors: Omri Nabil , Yahyaoui Mohammed , Banani Ridha , Messaoudi Sabri , Moussa Fathi , Abderrabba Manef 
Published: January 2016

Tryptophan methyl ester (Trp-ME) degrades with singlet oxygen and produce compounds which are photosensitizers and may react to form other derivatives such as N’-Formylkynurénine (NFK) and kynurenine, which are the final products of this oxidation. In order to study and optimize the molecular structure of NFK and determine its different thermodynamic properties, we performed a conformational analysis by DFT/B3LYP method with 3-21G basis set. Six most stable conformations were observed through the analysis of the potential energy surfaces, obtained by a relaxed scan of the dihedral angles. The most stable form of NFK has been registered for D[Formula: see text], D[Formula: see text], D[Formula: see text], D[Formula: see text], D[Formula: see text], and D[Formula: see text]. The study was conducted by HF and DFT/B3LYP with 6-31G(d,p), 6-3[Formula: see text](d,p) and 6-31[Formula: see text](d,p) basis sets, on the optimized geometry of the most stable conformation and its thermodynamic and orbital properties. Two absorption bands were recorded at [Formula: see text][Formula: see text]nm and at [Formula: see text][Formula: see text]nm and were also determined by TD-DFT method. They showed good agreement with the UV experimental spectrum which confirms that it is a powerful tool to determine the dynamic and static properties of molecules. The surface of the electrostatic potential (ESP) of the NFK was also analyzed.
H3K27 Demethylase JMJD3 Employs the NF-κB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis
Authors: Park Woo-Yong , Hong Beom-Jin , Lee Jungsul , Choi Chulhee , Kim Mi-Young 
Published: January 2016

Abstract
Histone methylation is a key epigenetic mark that regulates gene expression. Recently, aberrant histone methylation patterns caused by deregulated histone demethylases have been associated with carcinogenesis. However, the role of histone demethylases, particularly the histone H3 lysine 27 (H3K27) demethylase JMJD3, remains largely uncharacterized in melanoma. Here, we used human melanoma cell lines and a mouse xenograft model to demonstrate a requirement for JMJD3 in melanoma growth and metastasis. Notably, in contrast with previous reports examining T-cell acute lymphoblastic leukemia and hepatoma cells, JMJD3 did not alter the general proliferation rate of melanoma cells in vitro. However, JMJD3 conferred melanoma cells with several malignant features such as enhanced clonogenicity, self-renewal, and transendothelial migration. In addition, JMJD3 enabled melanoma cells not only to create a favorable tumor microenvironment by promoting angiogenesis and macrophage recruitment, but also to activate protumorigenic PI3K signaling upon interaction with stromal components. Mechanistic investigations demonstrated that JMJD3 transcriptionally upregulated several targets of NF-κB and BMP signaling, including stanniocalcin 1 (STC1) and chemokine (C–C motif) ligand 2 (CCL2), which functioned as downstream effectors of JMJD3 in self-renewal and macrophage recruitment, respectively. Furthermore, JMJD3 expression was elevated and positively correlated with that of STC1 and CCL2 in human malignant melanoma. Moreover, we found that BMP4, another JMJD3 target gene, regulated JMJD3 expression via a positive feedback mechanism. Our findings reveal a novel epigenetic mechanism by which JMJD3 promotes melanoma progression and metastasis, and suggest JMJD3 as a potential target for melanoma treatment. Cancer Res; 76(1); 161–70. ©2016 AACR.
Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis
Authors: Maxson Julia E. , Abel Melissa L. , Wang Jinhua , Deng Xianming , Reckel Sina , Luty Samuel B. , Sun Huahang , Gorenstein Julie , Hughes Seamus B. , Bottomly Daniel , Wilmot Beth , McWeeney Shannon K. , Radich Jerald , Hantschel Oliver , Middleton Richard E. , Gray Nathanael S. , Druker Brian J. , Tyner Jeffrey W. 
Published: January 2016

AbstractThe amount of genomic information about leukemia cells currently far exceeds our overall understanding of the precise genetic events that ultimately drive disease development and progression. Effective implementation of personalized medicine will require tools to distinguish actionable genetic alterations within the complex genetic landscape of leukemia. In this study, we performed kinase inhibitor screens to predict functional gene targets in primary specimens from patients with acute myeloid leukemia and chronic myelomonocytic leukemia. Deep sequencing of the same patient specimens identified genetic alterations that were then integrated with the functionally important targets using the HitWalker algorithm to prioritize the mutant genes that most likely explain the observed drug sensitivity patterns. Through this process, we identified tyrosine kinase nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity. Importantly, the integration of functional and genomic data using HitWalker allowed for prioritization of rare oncogenic mutations that may have been missed through genomic analysis alone. These mutations were sensitive to the multikinase inhibitor dasatinib, which antagonizes TNK2 kinase activity, as well as novel TNK2 inhibitors, XMD8-87 and XMD16-5, with greater target specificity. We also identified activating truncation mutations in other tumor types that were sensitive to XMD8-87 and XMD16-5, exemplifying the potential utility of these compounds across tumor types dependent on TNK2. Collectively, our findings highlight a more sensitive approach for identifying actionable genomic lesions that may be infrequently mutated or overlooked and provide a new method for the prioritization of candidate genetic mutations. Cancer Res; 76(1); 127–38. ©2015 AACR.
Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru 
Published: January 2016

Abstract
Glioblastoma (GBM)–initiating cells (GIC) are a tumorigenic subpopulation that are resistant to radio- and chemotherapies and are the source of disease recurrence. Therefore, the identification and characterization of GIC-specific factors is critical toward the generation of effective GBM therapeutics. In this study, we investigated the role of epithelial V-like antigen 1 (Eva1, also known as myelin protein zero-like 2) in stemness and GBM tumorigenesis. Eva1 was prominently expressed in GICs in vitro and in stem cell marker (Sox2, CD15, CD49f)-expressing cells derived from human GBM tissues. Eva1 knockdown in GICs reduced their self-renewal and tumor-forming capabilities, whereas Eva1 overexpression enhanced these properties. Eva1 deficiency was also associated with decreased expression of stemness-related genes, indicating a requirement for Eva1 in maintaining GIC pluripotency. We further demonstrate that Eva1 induced GIC proliferation through the activation of the RelB-dependent noncanonical NF-κB pathway by recruiting TRAF2 to the cytoplasmic tail. Taken together, our findings highlight Eva1 as a novel regulator of GIC function and also provide new mechanistic insight into the role of noncanonical NF-κB activation in GIC, thus offering multiple potential therapeutic targets for preclinical investigation in GBM. Cancer Res; 76(1); 171–81. ©2015 AACR.