bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐spatial analysis of forest residue utilization for bioenergy
Authors: Jacobson Ryan A. , Keefe Robert F. , Smith Alistair M.S. , Metlen Scott , Saul Darin A. , Newman Soren M. , Laninga Tamara J. , Inman Daniel 
Published: June 2016

AbstractThe alternative energy sector is expanding quickly in the USA since passage of the Energy Policy Act of 2005 and the Energy Independence and Security Act of 2007. Increased interest in wood‐based bioenergy has led to the need for robust modeling methods to analyze woody biomass operations at landscape scales. However, analyzing woody biomass operations in regions like the US Inland Northwest is difficult due to highly variable terrain and wood characteristics. We developed the Forest Residue Economic Assessment Model (FREAM) to better integrate with Geographical Information Systems and overcome analytical modeling limitations. FREAM analyzes wood‐based bioenergy logistics systems and provides a modeling platform that can be readily modified to analyze additional study locations. We evaluated three scenarios to test the FREAM’s utility: a local‐scale scenario in which a catalytic pyrolysis process produces gasoline from 181 437 Mg yr−1 of forest residues, a regional‐scale scenario that assumes a biochemical process to create aviation fuel from 725 748 Mg yr−1 of forest residues, and an international scenario that assumes a pellet mill producing pellets for international markets from 272 155 Mg yr−1 of forest residues. The local scenario produced gasoline for a modeled cost of $22.33 GJ−1*, the regional scenario produced aviation fuel for a modeled cost of $35.83 GJ−1 and the international scenario produced pellets for a modeled cost of $10.51 GJ−1. Results show that incorporating input from knowledgeable stakeholders in the designing of a model yields positive results. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd
Influence of FtsZ GTPase activity and concentration on nanoscale Z‐ring structure in vivo revealed by three‐dimensional Superresolution imaging
Authors: Lyu Zhixin , Coltharp Carla , Yang Xinxing , Xiao Jie 
Published: June 2016

ABSTRACTFtsZ is an essential bacterial cytoskeletal protein that assembles into a ring‐like structure (Z‐ring) at midcell to carry out cytokinesis. In vitro, FtsZ exhibits polymorphism in polymerizing into different forms of filaments based on its GTPase activity, concentration, and buffer condition. In vivo, the Z‐ring appeared to be punctate and heterogeneously organized, although continuous, homogenous Z‐ring structures have also been observed. Understanding how the Z‐ring is organized in vivo is important because it provides a structural basis for the functional role of the Z‐ring in cytokinesis. Here, we assess the effects of both GTPase activity and FtsZ concentration on the organization of the Z‐ring in vivo using three‐dimensional (3D) superresolution microscopy. We found that the Z‐ring became more homogenous when assembled in the presence of a GTPase‐deficient mutant, and upon overexpression of either wt or mutant FtsZ. These results suggest that the in vivo organization of the Z‐ring is largely dependent on the intrinsic polymerization properties of FtsZ, which are significantly influenced by the GTPase activity and concentration of FtsZ. Our work provides a unifying theme to reconcile previous observations of different Z‐ring structures, and supports a model in which the wt Z‐ring comprises loosely associated, heterogeneously distributed FtsZ clusters. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 725–734, 2016.
Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations
Authors: Wang Quan , Zheng Qing‐Chuan , Zhang Hong‐Xing 
Published: June 2016

ABSTRACTHistone acetylation is a very important regulatory mechanism in gene expression in the chromatin context. A new protein family‐YEATS domains have been found as a novel histone acetylation reader, which could specific recognize the histone lysine acetylation. AF9 is an important one in the YEATS family. Focused on the AF9‐H3K9ac (K9 acetylation) complex (ALY) (PDB code: 4TMP) and a serials of mutants, MUT (the acetyllsine of H3K9ac was mutated to lysine), F59A, G77A, and D103A, we applied molecular dynamics simulation and molecular mechanics Poisson−Boltzmann (MM‐PBSA) free energy calculations to examine the role of AF9 protein in recognition interaction. The simulation results and analysis indicate that some residues of the protein have significant influence on recognition and binding to H3K9ac peptides and hydrophobic surface show the hydrophobic interactions play an important role in the binding. Our work can give important information to understand how the protein AF9 recognizes the peptides H3K9ac. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 779–786, 2016.
“Shock and Go?” extracorporeal cardio‐pulmonary resuscitation in the golden‐hour of ROSC
Authors: Spangenberg Tobias , Meincke Felix , Brooks Stephanie , Frerker Christian , Kreidel Felix , Thielsen Thomas , Schmidt Tobias , Kuck Karl‐Heinz , Ghanem Alexander 
Published: June 2016

ObjectivesThe feasibility and outcomes of 35 consecutive patients subjected to eCPR in the tertiary cardiology center were investigated.BackgroundWhile conventional cardiopulmonary‐resuscitation (cCPR) often times achieves only mediocre outcomes extracorporeal cardiopulmonary‐resuscitation (eCPR) increasingly shifts into the focus of interest. However, the scientific evidence for eCPR is sparse, particularly in the cardiological setting.MethodsRetrospective chart analysis of 35 patients treated with eCPR between 01/2014 and 10/2015.ResultsThe duration of cCPR until initiation of eCPR was 73.8 ± 37.6 min and resulted in an initial pH of 6.9 ± 0.2 and serum lactate level of 14.5 ± 4.8 mmol/L. About 62% (n = 22) of the patients suffered from out of hospital cardiac arrest (OHCA), 85% (n = 30) of the overall events were witnessed and bystander‐CPR performed in 77% (n = 27) of cases. Cause of arrest was dominated by acute myocardial infarction (AMI, 71%), initial rhythm to a lesser degree by ventricular fibrillation/tachycardia (VF/VT, 57%). Almost all patients (n = 33, 94%) experienced return of spontaneous circulation (ROSC) after establishing extracorporeal life support (ECLS). In all 57% patients were successfully weaned from ECLS. Survival to discharge was 31% with predominantly good cerebral performance category (CPC 1‐2). Survivors were more likely to receive bystander‐CPR (P = 0.03) and the duration of cCPR until initiation of eCPR was significantly shorter (P = 0.004).ConclusionsOur data proves the exceptional level of efficiency of eCPR particularly when Bystander‐CPR has been initiated and there is a short duration of cCPR. © 2016 Wiley Periodicals, Inc.
Patient and lesion‐specific characteristics predict risk of major adverse cardiovascular events among patients with previous percutaneous coronary intervention undergoing noncardiac surgery
Authors: Armstrong Ehrin J. , Graham Laura , Waldo Stephen W. , Valle Javier A. , Maddox Thomas M. , Hawn Mary T. 
Published: June 2016

ObjectivesTo identify predictors of major adverse cardiovascular outcomes (MACE) among patients with prior percutaneous coronary intervention (PCI) who require noncardiac surgery.BackgroundPatients with prior PCI who undergo noncardiac surgery have an increased risk of postoperative MACE, but few studies have examined the association of PCI lesion characteristics with subsequent operative risk.MethodsPatients were identified using the VA Clinical Assessment, Reporting, and Tracking (CART) program. Patients who underwent noncardiac surgery within 2 years after stent placement were linked to VA and non‐VA surgical records. A multivariable logistic regression model was developed to identify predictors of postoperative MACE.ResultsAmong 12,621 patients with a history of prior PCI who underwent subsequent noncardiac surgery, 570 (4.5%) developed postoperative MACE. The median time from stent placement to surgery was 368 days (IQR 181–528). The strongest predictors of postoperative MACE were urgency of the operation, revised cardiac risk index, the indication for the prior PCI, and timing of the surgery after the PCI. Lesion characteristics independently associated with postoperative MACE included PCI to a distal (AOR 1.43, 95% CI 1.11–1.83) or ostial lesion (AOR 1.52, 95% CI 1.11–2.08), and lesion calcification (AOR 1.29, 95% CI 1.03–1.61), but stent length and target vessel were not independently associated with outcomes. Placement of a bare metal stent was also an independent predictor of MACE after noncardiac surgery (AOR 1.29, 95% CI 1.06–1.57).ConclusionsWhile patient and operative characteristics are the strongest predictors of MACE after noncardiac surgery, specific lesion characteristics including ostial or distal lesion location and calcification are novel risk factors for postoperative MACE. © 2016 Wiley Periodicals, Inc.
Efficient Photocatalytic Water Reduction Using In Situ Generated Knölker's Iron Complexes
Authors: Sun Yuan‐Yuan , Wang Hai , Chen Nan‐Yu , Lennox Alastair J J , Friedrich Aleksej , Xia Liang‐Min , Lochbrunner Stefan , Junge Henrik , Beller Matthias , Zhou Shaolin , Luo Shu‐Ping 
Published: June 2016

AbstractIn situ generated iron‐based Knölker complexes were found to be efficient catalysts in a fully non‐noble metal Cu–Fe photocatalytic water reduction system. These mononuclear iron catalysts were able to generate hydrogen up to 15 times faster than previously reported [Fe3(CO)12]. A reductive quenching mechanism was shown to operate by fluorescence experiments.
Metal Complexes Supported on Solid Matrices for Visible‐Light‐Driven Molecular Transformations
Authors: Mori Kohsuke , Yamashita Hiromi 
Published: June 2016

AbstractHybridization of visible‐light‐responsive metal complexes with solid matrices offers an attractive route for practical catalyst design of nanostructured photocatalysts that are operationally simple and can attain unprecedented reactions owing to synergistic effects. This Minireview highlights the precise architectures of hybrid photocatalysts that enable efficient and selective photochemical molecular transformations, including selective oxidation by O2 and H2 evolution from water. Several techniques for the immobilization of metal complexes are discussed, including encapsulation within zeolite cavities, anchoring within mesoporous channels, incorporation within the macroreticular space of ion‐exchange resins, intercalation within the interlayer spaces of layered materials, and anchoring onto the plasmonic colloidal Ag nanoparticles. The relationships between photoluminescence characteristics and photocatalytic activities of these hybrid materials are also discussed.
SnO2 “Russian Doll” Octahedra Prepared by Metalorganic Synthesis: A New Structure for Sub‐ppm CO Detection
Authors: Jońca Justyna , Ryzhikov Andrey , Kahn Myrtil L. , Fajerwerg Katia , Chapelle Audrey , Menini Philippe , Fau Pierre 
Published: June 2016

AbstractMicrometer‐sized hierarchical Sn3O2(OH)2 octahedra, which are self‐assembled one inside the other, resembling “Russian doll” organization, have been obtained by a metalorganic approach. This synthesis is based on the controlled hydrolysis of [Sn(NMe2)2]2 in the presence of an alkylamine ligand in an organic solvent (THF). The water content of the medium proved to be a key parameter for the formation of these multi‐walled octahedra. The resultant structures have been used as gas‐sensitive layers on micromachined silicon devices. During in situ heating, Sn3O2(OH)2 is oxidized to SnO2 while retaining the initial morphology. The sensors present outstanding dynamic responses at very low CO concentrations (7 % and 67 % resistance variation to 0.25 and 20 ppm CO, respectively, at an operating temperature of 500 °C). This superior gas‐sensing performance is closely related to the unique microstructure of the SnO2 multi‐walled octahedra.
Supramolecular Antibiotic Switches: A Potential Strategy for Combating Drug Resistance
Authors: Bai Haotian , Lv Fengting , Liu Libing , Wang Shu 
Published: June 2016

AbstractBacterial infectious disease is a serious public health concern throughout the world. Pathogen drug resistance, arising from both rational use and abuse/misuse of germicides, complicates the situation. Aside from developing novel antibiotics and antimicrobial agents, molecular approaches have become another significant method to overcome the problem of pathogen drug resistance. Established supramolecular systems, the antibiotic properties of which can be switched “on” and “off” through host–guest interactions, show great potential in combating issues regarding antibiotic resistance in the long term, as indicated by several recent studies. In this Concept, recently developed strategies for antibacterial regulation are summarized and further directions for research into antibiotic switches are proposed.
A Semisynthetic Approach to New Immunoadjuvant Candidates: Site‐Selective Chemical Manipulation of Escherichia coli Monophosphoryl Lipid A
Authors: D'Alonzo Daniele , Cipolletti Manuela , Tarantino Giulia , Ziaco Marcello , Pieretti Giuseppina , Iadonisi Alfonso , Palumbo Giovanni , Alfano Alberto , Giuliano Mariateresa , De Rosa Mario , Schiraldi Chiara , Cammarota Marcella , Parrilli Michelangelo , Bedini Emiliano , Corsaro Maria M. 
Published: June 2016

AbstractA semisynthetic approach to novel lipid A derivatives from Escherichia coli (E. coli) lipid A is reported. This methodology stands as an alternative to common approaches based exclusively on either total synthesis or extraction from bacterial sources. It relies upon the purification of the lipid A fraction from fed‐batch fermentation of E. coli, followed by its structural modification through tailored, site‐selective chemical reactions. In particular, modification of the lipid pattern and functionalization of the phosphate group as well as of the sole primary hydroxyl group were accomplished, highlighting the unusual reactivity of the molecule. Preliminary investigations of the immunostimulating activity of the new semisynthetic lipid A derivatives show that some of them stand out as promising, new immunoadjuvant candidates.
Dynamic Covalent Nanoparticle Building Blocks
Authors: Kay Euan R. 
Published: June 2016

AbstractRational and generalisable methods for engineering surface functionality will be crucial to realising the technological potential of nanomaterials. Nanoparticle‐bound dynamic covalent exchange combines the error‐correcting and environment‐responsive features of equilibrium processes with the stability, structural precision, and vast diversity of covalent chemistry, defining a new and powerful approach for manipulating structure, function and properties at nanomaterial surfaces. Dynamic covalent nanoparticle (DCNP) building blocks thus present a whole host of possibilities for constructing adaptive systems, devices and materials that incorporate both nanoscale and molecular functional components. At the same time, DCNPs have the potential to reveal fundamental insights regarding dynamic and complex chemical systems confined to nanoscale interfaces.
A novel optimization approach for oil and gas production process considering model parameters uncertainties
Authors: Gao Xianwen , Liu Tan , Yuan Qingyun , Wang Lina 
Published: June 2016

AbstractThrough analyzing the integrated oil and gas production process, a multi‐objective optimization model for the integrated oil and gas production process is established through considering nonlinear reservoir behaviour, multiphase flow in wells, and constraints from the surface facilities. In order to reduce the influence of model parameter uncertainty in the oil and gas production process, an error compensation method based on the Gaussian mixture model (GMM) is proposed to compensate the model. Non‐ dominated sorting genetic algorithm‐II (NSGA‐II) is used as the optimization algorithm. Moreover, an operational strategy using post‐ optimization is applied to solve the optimization model, so as to ensure the feasibility of the obtained optimal set‐point. Finally, a novel optimization approach for the oil and gas production process considering model parameter uncertainty is proposed. Simulation results indicate that the proposed optimization method is feasible and effective.
3‐Arylidene‐N‐hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity
Authors: Musso Loana , Cincinelli Raffaella , Zuco Valentina , De Cesare Michelandrea , Zunino Franco , Fallacara Anna Lucia , Botta Maurizio , Dallavalle Sabrina 
Published: June 2016

AbstractA series of compounds containing the N‐hydroxyoxindole scaffold were synthesized and evaluated for antitumor activity. The compounds showed potent antiproliferative activity against the wild‐type p53 IGROV‐1 ovarian carcinoma cell line and considerably lower efficacy against the mutant IGROV‐1/Pt1 subline that lacks p53 function. The differential response of ovarian carcinoma cells depending on p53 status was also reflected in the varied susceptibility to apoptosis of the treated cell lines. These results support a role for the p53 transcription factor as a determinant of cytotoxicity. The therapeutic potential of the most promising compound of the series was evaluated in the treatment of an IGROV‐1 xenograft growing as ascitic tumor in mice. Using intraperitoneal administration, daily treatment with the compound for four weeks produced a significant delay in the onset of ascites.
Efficacy and safety of dovitinib in pretreated patients with advanced squamous non‐small cell lung cancer with FGFR1 amplification: A single‐arm, phase 2 study
Authors: Lim Sung Hee , Sun Jong‐Mu , Choi Yoon‐La , Kim Hye Ryun , Ahn Soomin , Lee Ji Yun , Lee Se‐Hoon , Ahn Jin Seok , Park Keunchil , Kim Joo Hang , Cho Byoung Chul , Ahn Myung‐Ju 
Published: June 2016

BACKGROUNDFibroblast growth factor receptor 1 (FGFR1) amplification is a potential driving oncogene in squamous cell cancer (SCC) of the lung. The current phase 2 study evaluated the efficacy and tolerability of dovitinib, an FGFR inhibitor, in patients with advanced SCC of the lung.METHODSPatients with pretreated advanced SCC of the lung whose tumors demonstrated FGFR1 amplification of > 5 copies by fluorescence in situ hybridization were enrolled. Dovitinib at a dose of 500 mg was administered orally, once daily, on days 1 to 5 of every week, followed by 2 days off. The primary endpoint was overall response. Secondary endpoints were progression‐free survival, overall survival, and toxicity.RESULTSAll 26 patients were men with a median age of 68 years (range, 52‐80 years). The majority of patients were ever‐smokers. The median duration of dovitinib administration (28 days per cycle) was 2.5 months (range, 0.7‐8.6 months). The overall response rate was 11.5% (95% confidence interval [95% CI], 0.8%‐23.8%) and the disease control rate was 50% (95% CI, 30.8%‐69.2%), with 3 patients achieving partial responses. Response durations for the patients with partial responses were ≥4.5 months, ≥ 5.1 months, and 6.1 months, respectively. After a median follow‐up of 15.7 months (range, 1.2‐25.6 months), the median overall survival was 5.0 months (95% CI, 3.6‐6.4 months) and the median progression‐free survival was 2.9 months (95% CI, 1.5‐4.3 months). The most common grade 3 or higher adverse events were fatigue (19.2%), anorexia (11.5%), and hyponatremia (11.5%) (event severity was graded based on National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]).CONCLUSIONSTreatment with dovitinib demonstrated modest efficacy in patients with advanced SCC with FGFR1 amplification. Further studies to evaluate other biomarkers correlated with the efficacy of dovitinib in patients with SCC are warranted. Cancer 2016;122:3024‐3031. © 2016 American Cancer Society.
Randomized phase 2 neoadjuvant trial evaluating anastrozole and fulvestrant efficacy for postmenopausal, estrogen receptor–positive, human epidermal growth factor receptor 2–negative breast cancer patients: Results of the UNICANCER CARMINA 02 French trial (UCBG 0609)
Authors: Lerebours Florence , Rivera Sofia , Mouret‐Reynier Marie‐Ange , Alran Severine , Venat‐Bouvet Laurence , Kerbrat Pierre , Salmon Remy , Becette Veronique , Bourgier Céline , Cherel Pascal , Boussion Véronique , Balleyguier Corinne , Thibault Fabienne , Lavau‐Denes Sandrine , Nabholz Jean‐Marc , Sigal Brigitte , Trassard Martine , Mathieu Marie‐Christine , Martin Anne‐Laure , Lemonnier Jerome , Mouret‐Fourme Emmanuelle 
Published: June 2016

BACKGROUNDTreatment strategies for locally advanced breast cancer in elderly patients too frail to receive neoadjuvant chemotherapy and the introduction of new classes of drugs in the early 2000s have led to the consideration of endocrine therapy as a neoadjuvant treatment for younger hormone receptor (HR)–positive, postmenopausal patients not eligible for primary breast‐conserving surgery (BCS).METHODSThis was a multicenter, phase 2, randomized trial designed to evaluate as its primary objective the clinical response rate after up to 6 months of neoadjuvant endocrine therapy (NET) alone in HR‐positive/human epidermal growth factor receptor 2 (HER2)–negative patients with 1 mg of anastrozole (arm A) or 500 mg of fulvestrant (arm B). Secondary objectives included the BCS rate, tumor response assessment (breast ultrasound and magnetic resonance imaging), pathological response (Sataloff classification), safety profile, relapse‐free survival (RFS), and predictive markers of responses and outcomes.RESULTSFrom October 2007 to April 2011, 116 women (mean age, 71.6 years) with operable infiltrating breast adenocarcinoma (T2‐T4, N0‐N3, M0) were randomized to receive anastrozole or fulvestrant. The clinical response rates at 6 months were 52.6% (95% confidence interval [CI], 41%‐64%) in arm A and 36.8% (95% CI, 25%‐49%) in arm B. BCS was performed for 57.6% of arm A patients and 50% of arm B patients. The RFS rates at 3 years were 94.9% in arm A and 91.2% in arm B. The Preoperative Endocrine Prognostic Index status was significantly predictive of RFS. Both treatments were well tolerated.CONCLUSIONSBoth drugs are effective and well tolerated as NET in postmenopausal women with HR‐positive/HER2‐negative breast cancer. NET could be considered a treatment option in this subpopulation. Cancer 2016;122:3032‐3040. © 2016 American Cancer Society.
Vessel segmentation from abdominal magnetic resonance images: adaptive and reconstructive approach
Authors: Goceri Evgin , Shah Zarine K. , Gurcan Metin N. 
Published: June 2016

SummaryThe liver vessels, which have low signal and run next to brighter bile ducts, are difficult to segment from MR images. This study presents a fully automated and adaptive method to segment portal and hepatic veins on magnetic resonance images. In the proposed approach, segmentation of these vessels is achieved in four stages: (i) initial segmentation, (ii) refinement, (iii) reconstruction, and (iv) post‐processing. In the initial segmentation stage, k‐means clustering is used, the results of which are refined iteratively with linear contrast stretching algorithm in the next stage, generating a mask image. In the reconstruction stage, vessel regions are reconstructed with the marker image from the first stage and the mask image from the second stage. Experimental data sets include slices that show fat tissues, which have the same gray level values with vessels, outside the margin of the liver. These structures are removed in the last stage. Results show that the proposed approach is more efficient than other thresholding‐based methods. Copyright © 2016 John Wiley & Sons, Ltd.