bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells
Authors: Li Fei , Song Rui , Ao Lihua , Reece T. Brett , Cleveland Joseph C. , Dong Nianguo , Fullerton David A. , Meng Xianzhong 
Published: May 2017

Objective—
Extracellular matrix proteinases are implicated in the pathogenesis of calcific aortic valve disease. The ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) enzyme is secreted, matrix-associated metalloendopeptidase, capable of degrading extracellular matrix proteins, particularly matrilin 2. We sought to determine the role of the ADAMTS5/matrilin 2 axis in mediating the phenotype transition of valvular interstitial cells (VICs) associated with calcific aortic valve disease.

Approach and Results—
Levels of ADAMTS5, matrilin 2, and α-SMA (α-smooth muscle actin) were evaluated in calcified and normal human aortic valve tissues and VICs. Calcified aortic valves have reduced levels of ADAMTS5 and higher levels of matrilin 2 and α-SMA. Treatment of normal VICs with soluble matrilin 2 caused an increase in α-SMA level through Toll-like receptors 2 and 4, which was accompanied by upregulation of runt-related transcription factor 2 and alkaline phosphatase. In addition, ADAMTS5 knockdown in normal VICs enhanced the effect of matrilin 2. Matrilin 2 activated nuclear factor (NF) κB and NF of activated T cells complex 1 and induced the interaction of these 2 NFs. Inhibition of either NF-κB or NF of activated T cells complex 1 suppressed matrilin 2’s effect on VIC phenotype change. Knockdown of α-SMA reduced and overexpression of α-SMA enhanced the expression of pro-osteogenic factors and calcium deposit formation in human VICs.

Conclusions—
Matrilin 2 induces myofibroblastic transition and elevates pro-osteogenic activity in human VICs via activation of NF-κB and NF of activated T cells complex 1. Myofibroblastic transition in human VICs is an important mechanism of elevating the pro-osteogenic activity. Matrilin 2 accumulation associated with relative ADAMTS5 deficiency may contribute to the mechanism underlying calcific aortic valve disease progression.
Risk Factors for Pregnancy-Associated Stroke in Women With Preeclampsia
Authors: Miller Eliza C. , Gatollari Hajere J. , Too Gloria , Boehme Amelia K. , Leffert Lisa , Marshall Randolph S. , Elkind Mitchell S.V. , Willey Joshua Z. 
Published: May 2017

Background and Purpose—
Preeclampsia affects 3% to 8% of pregnancies and increases risk of pregnancy-associated stroke (PAS). Data are limited on which women with preeclampsia are at highest risk for PAS.

Methods—
Using billing data from the 2003 to 2012 New York State Department of Health inpatient database, we matched women with preeclampsia and PAS 1:3 to preeclamptic controls based on age and race/ethnicity. Pre-defined PAS risk factors included pregnancy complications, infection present on admission, vascular risk factors, prothrombotic states, and coagulopathies. We constructed multivariable conditional logistic regression models to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for independent risk factors for PAS.

Results—
Among women aged 12 to 55 years admitted to New York State hospitals for any reason during the study period (n=3 373 114), 88 857 had preeclampsia, and 197 of whom (0.2%) had PAS. In multivariable analysis, women with preeclampsia and stroke were more likely than controls to have severe preeclampsia or eclampsia (OR, 7.2; 95% confidence interval [CI], 4.6–11.3), infections present on admission (OR, 3.0; 95% CI, 1.6–5.8), prothrombotic states (OR, 3.5; 95% CI, 1.3–9.2), coagulopathies (OR, 3.1; 95% CI, 1.3–7.1), or chronic hypertension (OR, 3.2; 95% CI, 1.8–5.5). Additional analyses matched and stratified by severity of preeclampsia confirmed these results.

Conclusions—
Infections, chronic hypertension, coagulopathies, and underlying prothrombotic conditions increase PAS risk in women with preeclampsia. These women may warrant closer monitoring.
Arthroscopic Treatment of Osteochondral Lesions of the Talus With Allograft Cartilage Matrix
Authors: Ahmad Jamal , Maltenfort Mitchell 
Published: May 2017

Background: This prospective study evaluated the intermediate-term outcomes of operatively treating primary osteochondral lesions of the talus (OLT) of 1.5 cm2 or smaller with arthroscopic excision, microfracture, and allograft cartilage extracellular matrix (ECM). Methods: Between 2012 and 2015, 30 consecutive patients received allograft cartilage ECM at their microfractured OLT of 1.5 cm2 or smaller after failing nonoperative treatment. Preoperative and postoperative function and pain were graded using the Foot and Ankle Ability Measure (FAAM) and a visual analog scale (VAS), respectively. Postoperative imaging was assessed for osteochondral healing and degenerative changes. This included computed tomography (CT) at 6 months from surgery. Data regarding postoperative complications were recorded. All 30 patients that received allograft cartilage ECM for their OLT were evaluated for final follow-up at a mean of 20.2 months. Results: Mean FAAM increased from 51.4 preoperatively to 89.3 of 100 at final follow-up. Mean VAS decreased from 8.1 preoperatively to 1.7 of 10 at final follow-up. These differences between preoperative and postoperative function and pain were statistically significant ( P < .05). At 6 months from surgery, 2 patients (6.7%) received CT scans that revealed incomplete chondral formation at their OLT. At 19 months after surgery, a separate patient (3.3%) developed ankle arthritic changes. Conclusion: Treating OLTs with allograft cartilage ECM has not been previously reported. Using allograft cartilage ECM resulted in a high rate of improvement in ankle function and pain in patients with OLTs. These findings are important as allograft cartilage ECM could be of significant benefit for patients with OLTs. Level of Evidence: Level III, prospective comparative series.
Therapy-related myelofibrosis does not appear to exist
Authors: Masarova Lucia , Todisco Gabriele , Manshouri Taghi , Newberry Kate J. , Cortes Jorge E. , Kantarjian Hagop M. , Estrov Zeev , Verstovsek Srdan 
Published: May 2017

Key Points
There is no evidence to support the existence of therapy-related myelofibrosis. Therapy for previous malignancy has no impact on myelofibrosis prognosis.
Frontline Science: Functionally impaired geriatric CAR-T cells rescued by increased α5β1 integrin expression
Authors: Guha Prajna , Cunetta Marissa , Somasundar Ponnandai , Espat N Joseph , Junghans Richard P , Katz Steven C 
Published: May 2017

Abstract
Chimeric antigen receptor expressing T cells (CAR-T) are a promising form of immunotherapy, but the influence of age-related immune changes on CAR-T production remains poorly understood. We showed that CAR-T cells from geriatric donors (gCAR-T) are functionally impaired relative to CAR-T from younger donors (yCAR-T). Higher transduction efficiencies and improved cell expansion were observed in yCAR-T cells compared with gCAR-T. yCAR-T demonstrated significantly increased levels of proliferation and signaling activation of phosphorylated (p)Erk, pAkt, pStat3, and pStat5. Furthermore, yCAR-T contained higher proportions of CD4 and CD8 effector memory (EM) cells, which are known to have enhanced cytolytic capabilities. Accordingly, yCAR-T demonstrated higher levels of tumor antigen-specific cytotoxicity compared with gCAR-T. Enhanced tumor killing by yCAR-T correlated with increased levels of perforin and granzyme B. yCAR-T had increased α5β1 integrin expression, a known mediator of retroviral transduction. We found that treatment with M-CSF or TGF-β1 rescued the impaired transduction efficiency of the gCAR-T by increasing the α5β1 integrin expression. Neutralization of α5β1 confirmed that this integrin was indispensable for CAR expression. Our study suggests that the increase of α5β1 integrin expression levels enhances CAR expression and thereby improves tumor killing by gCAR-T.
Behavioral color vision in a cichlid fish: Metriaclima benetos
Authors: Escobar-Camacho Daniel , Marshall Justin , Carleton Karen L. 
Published: May 2017

Color vision is the capacity of discriminating color regardless of brightness. It is essential for many fish species as they rely on color discrimination for numerous ecological tasks. The study of color vision is important because it can unveil the mechanisms that shape coloration patterns, visual system sensitivities and hence, visual signals. In order to understand better the mechanisms underlying color vision an integrative approach is necessary. This usually requires combining behavioral, physiological, and genetic experiments with quantitative modeling, resulting in a distinctive characterization of the visual system.
Here we provide new data on the color vision of a rockdwelling cichlid from Lake Malawi: Metriaclima benetos. For this study we used a behavioral approach to demonstrate color vision through classical conditioning, complimented with modeling of color vision to estimate color contrast. For our experiments we took into account opsin coexpression and considered whether cichlids exhibit a dichromatic or a trichromatic visual system.
Behavioral experiments confirmed color vision in M. benetos; most fish were significantly more likely to choose the trained over the distracter stimuli, irrespective of brightness. Our results are supported by visual modeling which suggests that cichlids are trichromats and achieve color vision through color opponency mechanisms, which are a result of three different photoreceptor channels. Our analyses also suggest that opsin coexpression can negatively affect perceived color contrast. This study is particularly relevant for research on the cichlid lineage because cichlid visual capabilities and coloration patterns are implicated in their adaptive radiation.
Palliative care professionals' care and compassion for self and others: a narrative review
Authors: Mills Jason , Wand Timothy , Fraser Jennifer A 
Published: May 2017

Introduction: Compassion is arguably central to palliative care. However, calls for the restoring of compassionate care suggest a need for greater understanding and promotion of compassion in practice. Drawing upon the Foucauldian concept ‘Care of the Self’, this review explored the literature relating to palliative care professionals' self-care, self-compassion, and compassion for others. Methods: Three electronic databases were searched using identified key words. A thematic approach was used to synthesise and critically discuss the literature in the form of a narrative review. Results: Four themes were identified: (1) importance of self-care; (2) awareness, expression, and planning; (3) dimensions of self-care; and (4) balanced compassion. Approaches to self-care practice and research focused mainly on compassion fatigue or a coping paradigm. Conclusions: This review highlights both the importance and multifaceted nature of palliative care professionals' self-care, in relation to self-compassion and compassion for others. Despite widespread discussion, empirical knowledge of these variables is limited. Future research could usefully explore health promotion interventions in self-care practice, or a positive psychology paradigm that encompasses compassion and self-compassion as positive emotions associated with wellbeing.
Family experiences of the transition to palliative care in aged residential care (ARC): a qualitative study
Authors: Frey Rosemary , Foster Susan , Boyd Michal , Robinson Jackie , Gott Merryn 
Published: May 2017

Purpose: To address a gap in the literature by exploring bereaved families' perceptions of the transition to palliative care for their relative in long-term care. Methods: In-depth interviews were conducted with a convenience sample of twenty-six family members who were most involved in the care of residents who had died within the last 12 months. Interviews explored care, perceptions of staff palliative care knowledge, communication with staff, care planning and decision-making. The range of responses fit the Donabedian (1966) health care model of structure/process/outcome. In the case of long-term care, structure includes staff training; process is the manner of care and outcome would be a ‘good’ (or bad) death. Results: There was little evidence that a well-managed transition to a palliative approach to care was being initiated. Key themes included: 1) unrecognised need for transition; 2) information gaps and 3) feeling ‘out of the loop’. Ten subthemes were also identified. Implications: Engaging family and relevant internal and external health providers in care planning not only promotes care in line with resident wishes but also assists family bereavement. Results indicate the need for the development of a new collaborative, multidisciplinary model to enhance the delivery of palliative care in long-term care.
Obesity, Nutrition, and Physical Activity for People with Significant Disabilities
Authors: Grumstrup Brianna , Demchak MaryAnn 
Published: May 2017

This review of literature focuses on health issues for individuals with Intellectual Disabilities (ID), Intellectual and Developmental Disabilities (IDD), and Multiple Impairments (MI). This population has two to three times higher overweight and obesity prevalence than typically developing individuals. Furthermore, they have higher risk for obesity related diseases such as reduced lifespan and quality of life. Contributing factors for higher rates of overweight or obesity, effective interventions, and barriers to health knowledge and practice are discussed. Implications and future research needs are highlighted.
Finite Time Blow-up in a Delayed Diffusive Population Model with Competitive Interference
Authors: Parshad Rana D. , Bhowmick Suman , Quansah Emmanuel , Agrawal Rashmi , Upadhyay Ranjit Kumar 
Published: May 2017

AbstractIn the current manuscript, an attempt has been made to understand the dynamics of a time-delayed predator-prey system with modified Leslie-Gower and Beddington-DeAngelis type functional responses for large initial data. In Ref. Upadhyay and Agrawal, 83(2016) 821–837, it was shown that the model possesses globally bounded solutions, for small initial conditions, under certain parametric restrictions. Here, we show that actually solutions to this model system can blow-up in finite time, for large initial condition,evenunder the parametric restrictions derived in Ref. Upadhyay and Agrawal, 83(2016) 821–837. We prove blow-up in the delayed model, as well as the non-delayed model, providing sufficient conditions on the largeness of data, required for finite time blow-up. Numerical simulations show that actually the initial data does not have to be very large, to induce blow-up. The spatially explicit system is seen to possess non-Turing instability. We have also studied Hopf-bifurcation direction in the spatial system, as well as stability of the spatial Hopf-bifurcation using the central manifold theorem and normal form theory.
The development of aspectual marking in Cantonese-English bilingual children
Authors: Luk Zoe Pei‐sui , Shirai Yasuhiro 
Published: May 2017

AbstractThe present study investigates whether the tense-aspect development of Cantonese-English bilingual children conforms to the Aspect Hypothesis (Andersen and Shirai 1994. Discourse motivations for some cognitive acquisition principles.Studies in Second Language Acquisition16(2). 133–156.), which has been shown to predict the development of monolingual children of many different languages well, and whether the two languages influence each other during development. Analysis of longitudinal production data from three Cantonese-English bilinguals (Yip and Matthews 2000. Syntactic transfer in a Cantonese-English bilingual child.Bilingualism: Language and Cognition3(3). 193–208.) shows that the development of bilingual children resemble that of monolingual children and generally follow the Aspect Hypothesis, but to a lesser degree. Interactions were also observed in that the acquisition of the Cantonese progressive markerganwas accelerated by the-ingin the bilingual children, and transfer from Cantonese to English allowed them to use the English past tense marking with verbs of different lexical aspect early in their development, deviating from the prediction of the Aspect Hypothesis.
La planeación en el municipio y resguardo de Jambaló (Colombia)
Authors: Castaño Canoas Máryuri 
Published: May 2017

<p>El presente artículo propone mostrar un análisis sobre los planes de vida de los indígenas Nasa del Norte del Cauca (departamento en Colombia) y su forma de organización, específicamente los que se ubican en el municipio y resguardo de Jambaló, con relación a los planes de desarrollo convencional, haciendo énfasis en las divergencias y convergencias entre una y otra forma de planificación, a fin de enriquecer la discusión sobre las formas de planear en el país y la necesidad de resignificar el desarrollo y la vida cotidiana. </p>
Interventions Targeting Sensory Challenges in Autism Spectrum Disorder: A Systematic Review
Authors: Weitlauf Amy S. , Sathe Nila , McPheeters Melissa L. , Warren Zachary E. 
Published: May 2017

CONTEXT:
Sensory challenges are common among children with autism spectrum disorder (ASD).

OBJECTIVE:
To evaluate the effectiveness and safety of interventions targeting sensory challenges in ASD.

DATA SOURCES:
Databases, including Medline and PsycINFO.

STUDY SELECTION:
Two investigators independently screened studies against predetermined criteria.

DATA EXTRACTION:
One investigator extracted data with review by a second. Investigators independently assessed risk of bias and strength of evidence (SOE), or confidence in the estimate of effects.

RESULTS:
Twenty-four studies, including 20 randomized controlled trials (RCTs), were included. Only 3 studies had low risk of bias. Populations, interventions, and outcomes varied. Limited, short-term studies reported potential positive effects of several approaches in discrete skill domains. Specifically, sensory integration-based approaches improved sensory and motor skills-related measures (low SOE). Environmental enrichment improved nonverbal cognitive skills (low SOE). Studies of auditory integration-based approaches did not improve language (low SOE). Massage improved symptom severity and sensory challenges in studies with likely overlapping participants (low SOE). Music therapy studies evaluated different protocols and outcomes, precluding synthesis (insufficient SOE). Some positive effects were reported for other approaches, but findings were inconsistent (insufficient SOE).

LIMITATIONS:
Studies were small and short-term, and few fully categorized populations.

CONCLUSIONS:
Some interventions may yield modest short-term (&lt;6 months) improvements in sensory- and ASD symptom severity-related outcomes; the evidence base is small, and the durability of the effects is unclear. Although some therapies may hold promise, substantial needs exist for continuing improvements in methodologic rigor.
PENGKAJIAN TENTANG PERIKANAN BERKELANJUTAN DI TANJUNGBALAI ASAHAN SUMATERA UTARA
Authors: Nababan Benardo , Wiyono Eko Sri , Mustaruddin Mustaruddin 
Published: May 2017

Pengelolaan perikanan yang dilakukan pemerintah sudah diarahkan untuk mencapai perikanan yang berkelanjutan, namun upaya yang dilakukan belum mendapat dukungan yang baik dari nelayan di Tanjungbalai Asahan, Sumatera Utara. Hal ini terlihat dari banyaknya nelayan yang tidak mematuhi aturan yang dibuat. Evaluasi terhadap kepatuhan nelayan sangatlah diperlukan karena manajemen perikanan merupakan kegiatan manajemen yang berfokus pada sumberdaya manusia dan aktivitasnya di bidang perikanan. Pengelola harus benar-benar memahami bagaimana nelayan atau stakeholder perikanan merespon segala peraturan yang dibuat. Penelitian ini bertujuan untuk menentukan faktor-fakor yang mempengaruhi kepatuhan nelayan dalam mendukung perikanan yang berkelanjutan ditinjau dari aspek karakteristik sosial-ekonomi dan persepsi. Metode yang digunakan adalah analisis model persamaan struktural. Dalam analisis ini digunakan 4 variabel laten, yaitu karakteristik sosial-ekonomi nelayan, persepsi terhadap kriteria alat penangkapan ikan yang ramah lingkungan, persepsi terhadap keberadaan sumberdaya perikanan, dan kepatuhan terhadap aturan. Hasil penelitian menunjukkan bahwa faktor-faktor yang mempengaruhi kepatuhan nelayan, antara lain; karakteristik sosial-ekonomi nelayan (organisasi, sosialisasi, investasi, dan pendapatan), persepsi terhadap kriteria alat penangkapan ikan yang ramah lingkungan, dan persepsi terhadap keberadaan sumberdaya perikanan.
DINAMIKA POPULASI DAN TINGKAT PEMANFAATAN UDANG WINDU (Penaeus semisulcatus de Haan, 1844) DI PERAIRAN BALIKPAPAN
Authors: Tirtadanu Tirtadanu , Wedjatmiko Wedjatmiko , Lestari Pratiwi 
Published: May 2017

Udang windu (Penaeus semisulcatus de Haan, 1844) di perairan Kalimantan Timur saat ini diduga berada dalam tahapan lebih tangkap, sehingga kajian dinamika populasi udang windu di perairan Balikpapan merupakan informasi yang penting untuk dilakukan.Penelitian ini bertujuan untuk mengkaji dinamika populasi dan tingkat pemanfaatan udang windu sebagai dasar dalam pengelolaan perikanan udang di Balikpapan.Penelitian ini dilakukan pada bulan Februari – November 2016.Metode yang digunakan adalah random sampling dengan analisis menggunakan model analitik. Hasil penelitian menunjukkan ukuran panjang karapas asimptotik (CL∞) udang jantan sebesar 47,5 mmCL dengan laju pertumbuhan (K) 1,72 per tahun dan panjang karapas asimptotik (CL∞) udang betina 53,7 mmCL dengan laju pertumbuhan (K) 1,53 per tahun. Ukuran rata-rata pertama kali tertangkap udang (Lc) sebesar 31,5 mmCL lebih kecil dibandingkan ukuran rata-rata pertama kali matang gonad (Lm) sebesar 39,63 mmCL, menunjukkan sebagian besar udang tertangkap sebelum memijah. Tingkat pemanfaatan udang windu berada pada tahap lebih tangkap (overfishing) dengan nilai laju pengusahaan (E) sebesar 0,65 pada jantan dan 0,77 pada betina, sehingga disarankan untuk melakukan pengurangan upaya penangkapan sebesar 42% dan pengaturan jaring dengan ukuran tertangkap lebih besar dari 39 mmCL.The green tiger prawn (Penaeus semisulcatus de Haan, 1844) in Kalimantan Timur were estimated in stages of overfishing, so dynamic population of green tiger prawn was important information needed to do. Aim of this research were to study about dynamic population and exploitation rate of green tiger prawn as basis management for shrimp fisheries in Balikpapan. This research conducted on February – November 2016. The method used was random sampling and the analysis used was analytical model. The results showed that carapace asymptotic length (CL∞) of male green tiger prawn was 47,5 mmCL and the growth rate was 1,72 year-1. Carapace asymptotic length (CL∞) of female prawn was 53,7 mmCL and the growth rate was 1,53 year-1. Length at first captured was 31,5 mmCL, smaller than length at first matured that was 39,63 mmCL so most of shrimps captured hadn’t spawned yet. Exploitation rate of the green tiger prawn was on stage of overfishing with the value of exploitation rate was 0,65 for male and 0,77 for female, so it was suggested to reduce fishing effort by 42% and mesh size regulation with the size allowable catch was bigger than 39 mmCL.