bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of self-managed oral anticoagulant therapy in patients with recurrent venous thromboembolism
Authors: Skjøth Flemming , Lerkevang Grove Erik , Brønnum Nielsen Peter , Christensen Thomas Decker , Bjerregaard Larsen Torben 
Published: June 2016

SummaryPatient-self-management (PSM) of oral anticoagulant therapy (OAT) with vitamin K antagonists for venous thromboembolism (VTE) has demonstrated efficacy in randomised, controlled trials. The aim of this study was to evaluate the effectiveness of PSM of OAT in everyday clinical practice. Prospectively registered patient data were obtained from databases at two hospitals, and cross-linkage with national patient registries provided detailed information on comorbidities and events. Patients with VTE performing PSM affiliated to major PSM centres were included as cases (N=444). A control group of patients on conventional treatment was propensity score selected in a ratio of 1:5 (N=2220) within matched groups. The effectiveness and safety was estimated using recurrent VTE, major bleeding events and all-cause death as outcomes. We found a lower rate of recurrent VTE among PSM patients compared to the control group with a hazard ratio (HR) of 0.63; 95 % confidence interval (CI) 0.42–0.95, whereas no difference was seen with bleeding (HR: 0.95; 95 % CI 0.44–2.02). The risk of all-cause death was lower for PSM patients (HR: 0.41; 95 % CI 0.21–0.81). A net clinical benefit analysis sums the effect on recurrent VTE and bleeding up to a weighted rate difference of 0.86 (95 % CI 0.00–1.72) in favour of PSM. In conclusion, PSM of anticoagulant treatment was associated with a statistically significant lower rate of recurrent VTE and all-cause death compared to patients on conventionally managed anticoagulant treatment. All major thromboembolic outcomes were less frequent among self-managed patients, whereas bleedings were observed with similar frequency.Supplementary Material to this article is available online at www.thrombosis-online.com.
The Crisis of Testimony in Historiography
Authors: Ahlskog Jonas 
Published: June 2016

Abstract
The essay examines the recent discussion about a “crisis of testimony” in historiography. Central to this discussion is the question of how it is possible for human testimony to convey information about the limit experiences of 20th century history. Given that the credibility of testimony is assessed by appealing to our previous understanding of what is credible, testimony to limit experiences risks being dismissed as unbelievable or implausible. This issue has recently been addressed in the work of Paul Ricoeur, Hayden White and Gert-Jan van der Heiden among others. In the first part of this essay, I show that the current idea of a crisis of testimony is a consequence of focusing too exclusively on the content of extraordinary testimony. I argue that such a focus has affinities with David Hume’s reductionist understanding of testimonial knowledge; even though the authors discussed cannot properly be labelled reductionists themselves. In the second part of the essay, I open up the issue of extraordinary testimony from a perspective that places the relationship between the speaker and the addressee at the heart of testimonial knowledge. My aim is to show that if we attend to the way in which testimonial knowledge involves dependence on the authority of another person, then the current idea of a crisis of testimony will dissolve itself. In conclusion, I argue that there is an important ethical dimension to the question of understanding extraordinary testimony.
Wave–Mean Flow Interactions and the Maintenance of Superrotation in a Terrestrial Atmosphere
Authors: Dias Pinto João Rafael , Mitchell Jonathan Lloyd 
Published: June 2016

Abstract
The interplay between mean meridional circulation and transient eddies through wave–mean flow interaction processes defines the general behavior of any planetary atmospheric circulation. Under a higher-Rossby-number regime, equatorward momentum transports provided by large-scale disturbances generate a strong zonal flow at the equatorial region. At intermediate Rossby numbers, equatorial Kelvin waves play a leading role in maintaining a superrotating jet over the equator. However, at high Rossby numbers, the Kelvin wave only provides equatorward momentum fluxes during spinup, and the wave–mean flow process that maintains this strongly superrotating state has yet to be identified. This study presents a comprehensive analysis of the tridimensional structure and life cycle of atmospheric waves and their interaction with the mean flow, which maintains the strong, long-lived superrotating state in a higher-Rossby-number-regime atmosphere. The results show that the mean zonal superrotating circulation is maintained by the dynamical interaction between mixed baroclinic–barotropic Rossby wave modes via low-frequency variations of the zonal-mean state in short and sporadic periods of stronger instability. The modulation of amplitude of the equatorial and extratropical Rossby waves suggests a nonlinear mechanism of eddy–eddy interaction between these modes.
Small-Scale Variability of the Raindrop Size Distribution and Its Effect on Areal Rainfall Retrieval
Authors: Raupach Timothy H. , Berne Alexis 
Published: June 2016

AbstractThe drop size distribution (DSD) describes the microstructure of liquid precipitation. The high variability of the DSD reflects the variety of microphysical processes controlling raindrop properties and affects the retrieval of rainfall. An analysis of the effects of DSD subgrid variability on areal estimation of precipitation is presented. Data used were recorded with a network of disdrometers in Ardèche, France. DSD variability was studied over two typical scales: 5 km × 5 km, similar to the ground footprint size of the Global Precipitation Measurement (GPM) spaceborne weather radar, and 2.8 km × 2.8 km, an operational pixel size of the Consortium for Small-Scale Modeling (COSMO) numerical weather model. Stochastic simulation was used to generate high-resolution grids of DSD estimates over the regions of interest, constrained by experimental DSDs measured by disdrometers. From these grids, areal DSD estimates were derived. The error introduced by assuming a point measurement to be representative of the areal DSD was quantitatively characterized and was shown to increase with the size of the considered area and with drop size and to decrease with the integration time. The controlled framework allowed for the accuracy of retrieval algorithms to be investigated. Rainfall variables derived by idealized simulations of GPM- and COSMO-style algorithms were compared to subgrid distributions of the same variables. While rain rate and radar reflectivity were well represented, the estimated drop concentration and mass-weighted mean drop diameter were often less representative of subgrid values.
Anxiety and depression in probable migraine: A population-based study
Authors: Song Tae-Jin , Cho Soo-Jin , Kim Won-Joo , Yang Kwang Ik , Yun Chang-Ho , Chu Min Kyung 
Published: June 2016

Background Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population. Methods We recruited Korean individuals aged 19–69 years via stratified random sampling and assessed headache type, anxiety, and depression among them using structured interviews. Results In a representative sample of 2695 individuals, 143 (5.3%) and 379 (14.1%) had migraine and PM, respectively. Fewer patients with PM had anxiety (17.7% vs. 30.1%, p = 0.002) and depression (8.7% vs. 16.8%, p = 0.007) compared to those with migraine. Prevalence of anxiety and depression was lower in people with PM than in those with migraine in univariable analysis, but insignificant after including headache intensity and headache frequency for adjustment. Headache frequency, headache intensity, and impact of headache were significantly higher among PM and migraine patients with anxiety and depression than among those without. Conclusions The prevalence of anxiety and depression was lower among individuals with PM compared to those with migraine. However, they were still prevalent and associated with an exacerbation of symptoms among individuals with PM.
Reduction of Laboratory Utilization in the Intensive Care Unit
Authors: Raad Samih , Elliott Rachel , Dickerson Evan , Khan Babar , Diab Khalil 
Published: June 2016

Objective: In our academic intensive care unit (ICU), there is excess ordering of routine laboratory tests. This is partially due to a lack of transparency of laboratory-processing costs and to the admission order plans that favor daily laboratory test orders. We hypothesized that a program that involves physician and staff education and alters the current ICU order sets will lead to a sustained decrease in routine laboratory test ordering. Design: Prospective cohort study. Setting: Academic closed medical ICU (MICU). Patients: All patients admitted to the MICU. Methods: We consistently educated residents, faculty, and staff about laboratory test costs. We removed the daily laboratory test option from the admission order sets and asked residents to order needed laboratory test results every day. We only allowed the G3+I-STAT (arterial blood gas only) cartridges in the MICU in hopes of decreasing duplicative laboratory test results. We added laboratory review to the daily rounding checklist. Measurement and Main Results: Total number of laboratory tests per patient-day decreased from 39.43 to an average of 26.74 ( P <.001) over a 9-month period. The number of iSTAT laboratory tests per patient-day decreased from 7.37 to an average of 1.16 ( P < .001) over the same time period. The number of iSTAT/central laboratory processing duplicative laboratory tests per patient-day decreased from 0.17 to an average of 0.01 ( P < .001). The percentage of patients who have daily laboratory test orders decreased from 100% to an average of 11.94% ( P <. 001). US$123 436 in direct savings and US$258 035 dollars in indirect savings could be achieved with these trends. Intensive care unit morbidity and mortality were not impacted. Conclusion: A simple technique of resident, nursing, and ancillary staff education, combined with alterations in order sets using electronic medical records, can lead to a sustained reduction in laboratory test utilization over time and to significant cost savings without affecting patient safety.
Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo
Authors: Huber Alexandra , Kallerup Rie S , Korsholm Karen S , Franzyk Henrik , Lepenies Bernd , Christensen Dennis , Foged Camilla , Lang Roland 
Published: June 2016

The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for TDM and its synthetic analogue trehalose 6,6'-dibehenate (TDB) has raised interest in development of synthetic Mincle ligands as novel adjuvants. Trehalose mono- (TMXs) and diesters (TDXs) with symmetrically shortened acyl chains [denoted by X: arachidate (A), stearate (S), palmitate (P), and myristate (M)] were tested. Upon stimulation of murine macrophages, G-CSF secretion and NO production were strongly augmented by all TDXs tested, in a wide concentration range. In contrast, the TMXs triggered macrophage activation only at high concentrations. Macrophage activation by all TDXs required Mincle, but was independent of MyD88. The superior capacity of TDXs for activating macrophages was paralleled by direct binding of TDXs, but not of TMXs, to a Mincle-Fc fusion protein. Insertion of a short polyethylene glycol between the sugar and acyl chain in TDS reduced Mincle-binding and macrophage activation. Immunization of mice with cationic liposomes containing the analogues demonstrated the superior adjuvant activity of trehalose diesters. Overall, immune activation in vitro and in vivo by trehalose esters of simple fatty acids requires two acyl chains of length and involves Mincle.
The effect of an occupation-based intervention in patients with hand-related disorders grouped using the sense of coherence scale: Study protocol
Authors: Hansen Alice Ø , Cederlund Ragnhild , Kristensen Hanne K , Tromborg Hans 
Published: June 2016

Introduction High-quality rehabilitation is required if patients with hand-related disorders are to achieve high levels of functioning. Occupation-based interventions are effective in stroke, hip fractures, and for elderly people, but there is limited knowledge of their effect in hand therapy. Sense of coherence may affect rehabilitation outcome, since patients with weak sense of coherence experience lower functioning, are less satisfied with their occupational performance, have inferior quality of life and more pain compared to patients with stronger sense of coherence . Method Following SPIRIT guidelines, we present a randomized, controlled, parallel-grouped trial. It investigates the effect of an occupation-based intervention for outpatients with hand-related disorders and whether sense of coherence influences the outcomes. Patients are stratified into three groups (weak, medium and strong sense of coherence) and randomized to occupation-based or exercise-based hand therapy. Sample size calculation indicates that 70 patients are required in each intervention in each separate sense of coherence group. With an expected drop-out of 20%, a total of 504 participants will be randomized. Primary analysis is score change in functioning measured by the Disabilities of the Arm, Shoulder and Hand from start of rehabilitation to three months’ follow-up. Secondary outcomes are self-evaluated occupational performance and satisfaction with occupational performance. Conclusion This study will add valuable knowledge to the field of hand therapy regarding the therapeutic use of occupations that patients find meaningful. Moreover, it may show which patients will benefit the most from an occupation-based intervention in relation to their sense of coherence.
Fluoroquinolone resistance colonization from initial to repeat prostate biopsy
Authors: Liss Michael A , Gillis Kyle , Sakamoto Kyoko , Fierer Joshua 
Published: June 2016

Purpose: Fluoroquinolone (FQ) resistant (FQR) bacteria are a major cause of infection after transrectal prostate biopsy (TRPB). We determined the prevalence of FQR in initial and subsequent rectal cultures from men undergoing repeat prostate biopsies. Materials and methods: After IRB approval, men presenting for TRPB at the San Diego Veterans Affairs Medical Center between January 1, 2010, and February 6, 2014, underwent pre-TRPB rectal culture. The rectal swab was collected from the patient immediately prior to TRPB. Rectal swabs were streaked onto locally prepared ciprofloxacin-supplemented (4 mg/L) MacConkey agar plates. A representative colony was selected for identification and susceptibility testing. Results: Of 617 patients who had rectal cultures done, 7% (43/617) had a repeat rectal culture performed in relation to a second prostate biopsy. All cipro-resistant bacteria isolated were Escherichia coli. The median time and interquartile range between first and second biopsy was 2.3 years (range 1.2–3.6 years). On first biopsy, 16.3% (7/43) had FQR, which was not statistically different from the 18.6% of patients who had FQR on their second biopsy ( p=0.78). Overall, 74% (32/43) of patients tested absent for FQR at both prostate biopsies, and 9.3% (4/43) tested present at both ( p=0.015). However, 9.3% (4/43) converted from absent to present FQR, and 7.0% (3/43) converted from present FQR to absent ( p=0.69). Seventy percent of the FQR E. coli were also resistant to gentamicin, and 22% were resistant to cefepime. Conclusions: Patients undergoing prostate biopsy should be examined for FQR prior to each individual biopsy because prior culture results do not always predict whether a patient will be colonized with FQR E. coli.
Idelalisib in the management of lymphoma
Authors: Cheah Chan Yoon , Fowler Nathan H. 
Published: June 2016

AbstractInhibition of the phosphatidylinositol-3-kinase (PI3K) pathway as an anticancer therapeutic strategy was realized with the approval of the orally bioavailable small molecule PI3Kδ inhibitor idelalisib. In this focused review, we highlight the rationale for targeting the pathway in lymphomas, provide a brief summary of the preclinical data, and describe the clinical experience with this agent in patients with lymphoma. We describe some of the idiosyncratic toxicities of this agent, some of the mechanisms of resistance, and some of the ongoing combination strategies.
Disclosing Jackson Pollock’s palette in Alchemy (1947) by non-invasive spectroscopies
Authors: Rosi F. , Grazia C. , Fontana R. , Gabrieli F. , Pensabene Buemi L. , Pampaloni E. , Romani A. , Stringari C. , Miliani C. 
Published: June 2016

Abstract

Alchemy (1947, Peggy Guggenheim Collection, Venice) is one of the most materic works by J. Pollock, whose palette is extensive, ranging from white to yellow, red, green, violet, blue, black, and silver. Each layer of color was laid on top of a previously dried one and effectively separated from the lower one forming a quite complex stratigraphy with colors intersecting each other. In this study, a non-invasive multi-technique method combining point analysis with Vis–NIR multispectral imaging has been exploited to give insights on the painting technique of the American abstract expressionist. The molecular identification of pigments, colorants and extenders contained in fifteen different paints has been achieved combining key spectral markers from elemental, electronic and vibrational spectroscopies. For those colors exhibiting similar hues but different chemical compositions, a mapping procedure based on false color rendering, obtained by properly mixing three spectral planes from the Vis–NIR multispectral imaging set, has been successfully applied. Relevant for the understanding of the evolution of Pollock’s drip technique is the identification of both traditional oil-based paints and oil-modified alkyd media. Point analysis by reflection FTIR scattered throughout the painting enabled mapping the distinct use of traditional and new binding media among painted, squeezed and dripped paints.
Solid viscosity of fluid-saturated porous rock with squirt flows at seismic frequencies
Authors: Deng Wubing , Morozov Igor B. 
Published: June 2016

We have developed a macroscopic model for a two-phase medium (solid porous rock frame plus saturating pore fluid) with squirt flows based on Lagrangian continuum mechanics. The model focuses on improved physics of rock deformation, including explicit differential equations in time domain, causality, linearity, frequency-independent parameters with clear physical meanings, and an absence of mathematical internal or memory variables. The approach shows that all existing squirt-flow models can be viewed as microscopic models of viscosity for solid rock. As in existing models, the pore space is differentiated into compliant and relatively stiff pores. At lower frequencies, the effects of fluid flows within compliant pores are described by bulk and shear solid viscosities of the effective porous frame. Squirt-flow effects are “Biot consistent,” which means that there exists a viscous coupling between the rock frame and the fluid in stiff pores. Biot’s poroelastic effects associated with stiff porosity and global flows are also fully included in the model. Comparisons with several squirt-flow models show good agreement in predicting wave attenuation to approximately 1 kHz frequencies. The squirt-flow viscosity for sandstone is estimated in the range of [Formula: see text], which is close to field observations. Because of its origins in rigorous mechanics, the model can be used to describe any wavelike and transient deformations of heterogeneous porous media or finite bodies encountered in many field and laboratory experiments. The model also leads to new numerical algorithms for wavefield modeling, which are illustrated by 1D finite-difference waveform modeling.
Spatial and temporal evolution of Cenozoic carbonate platforms on the continental margins of the South China Sea: Response to opening of the ocean basin
Authors: Wu Shiguo , Zhang Xinyuan , Yang Zhen , Wu Tuoyu , Gao Jinwei , Wang Dawei 
Published: June 2016

Widespread and tremendously thick Cenozoic carbonate sequences are present along the margins of the South China Sea (SCS). However, most of the sequences have been drowned since the Late Miocene. The stratigraphic architecture of the carbonate platforms in the SCS can provide information on the tectonic evolution of the ocean basin. Based on 2D/3D seismic, well and regional geologic data, we have interpreted the Cenozoic SCS carbonate platforms along the continental margins. The carbonate platforms developed during rifting and initiated on the fault block of the conjugate rifted margins. Most of the carbonate platforms became drowned after the Middle Miocene. The Malampaya Carbonate Sequences, which have thicknesses of greater than 600 m, developed on a horst of an Oligocene rifted block. Tectonic subsidence provided accommodation for the growth of the carbonate platforms. Tectonic tilting, faulting, and the foreland bulge controlled the distributions, thicknesses, and horizontal seismic reflection variations of the drowned carbonate platforms. The tectonic evolution and relative sea-level fluctuations controlled the depositional cycles of the carbonate platforms. We quantitatively calculated the factors that affected the extension and subsidence rates using balanced cross section and backstepping techniques. Our results have demonstrated that the carbonate platforms flourished during the Middle Miocene due to stable tectonic conditions and shrank during the Late Miocene due to rapid subsidence. The relative sea level exerted a second-order control on the evolutionary trend of the carbonate platforms and a third-order control on the evolutionary periods in each stage.
Energetic cost determines voluntary movement speed only in familiar environments
Authors: Seebacher Frank , Borg Jason , Schlotfeldt Kathryn , Yan Zhongning 
Published: June 2016

ABSTRACTLocomotor performance is closely related to fitness. However, in many ecological contexts, animals do not move at their maximal locomotor capacity, but adopt a voluntary speed that is lower than maximal. It is important to understand the mechanisms that underlie voluntary speed, because these determine movement patterns of animals across natural environments. We show that voluntary speed is a stable trait in zebrafish (Danio rerio), but there were pronounced differences between individuals in maximal sustained speed, voluntary speed and metabolic cost of locomotion. We accept the hypothesis that voluntary speed scales positively with maximal sustained swimming performance (Ucrit), but only in unfamiliar environments (1st minute in an open-field arena versus 10th minute) at high temperature (30°C). There was no significant effect of metabolic scope on Ucrit. Contrary to expectation, we rejected the hypothesis that voluntary speed decreases with increasing metabolic cost of movement, except in familiar spatial (after 10 min of exploration) and thermal (24°C but not 18 or 30°C) environments. The implications of these data are that the energetic costs of exploration and dispersal in novel environments are higher than those for movement within familiar home ranges.