bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fate of pyruvate dictates cell growth by modulating cellular redox potential
Authors: Toshniwal Ashish G. , Lam Geanette , Bott Alex J. , Cluntun Ahmad A. , Skabelund Rachel , Nam Hyuck-Jin , Wisidagama Dona R. , Thummel Carl S. , Rutter Jared 
Published: September 2024

AbstractPyruvate occupies a central node in carbohydrate metabolism such that how it is produced and consumed can optimize a cell for energy production or biosynthetic capacity. This has been primarily studied in proliferating cells, but observations from the post-mitoticDrosophilafat body led us to hypothesize that pyruvate fate might dictate the rapid cell growth observed in this organ during development. Indeed, we demonstrate that augmented mitochondrial pyruvate import prevented cell growth in fat body cellsin vivoas well as in cultured mammalian hepatocytes and human hepatocyte-derived cellsin vitro. This effect on cell size was caused by an increase in the NADH/NAD+ratio, which rewired metabolism toward gluconeogenesis and suppressed the biomass-supporting glycolytic pathway. Amino acid synthesis was decreased, and the resulting loss of protein synthesis prevented cell growth. Surprisingly, this all occurred in the face of activated pro-growth signaling pathways, including mTORC1, Myc, and PI3K/Akt. These observations highlight the evolutionarily conserved role of pyruvate metabolism in setting the balance between energy extraction and biomass production in specialized post-mitotic cells.
Protein Language Models: Is Scaling Necessary?
Authors: Fournier Quentin , Vernon Robert M. , van der Sloot Almer , Schulz Benjamin , Chandar Sarath , Langmead Christopher James 
Published: September 2024

AbstractPublic protein sequence databases contain samples from the fitness landscape explored by nature. Protein language models (pLMs) pre-trained on these sequences aim to capture this landscape for tasks like property prediction and protein design. Following the same trend as in natural language processing, pLMs have continuously been scaled up. However, the premise that scale leads to better performance assumes that source databases provide accurate representation of the underlying fitness landscape, which is likely false. By developing an efficient codebase, designing a modern architecture, and addressing data quality concerns such as sample bias, we introduce AMPLIFY, a best-in-class pLM that is orders of magnitude less expensive to train and deploy than previous models. Furthermore, to support the scientific community and democratize the training of pLMs, we have open-sourced AMPLIFY’s pre-training codebase, data, and model checkpoints.
Plasticity in the pectoral fin skeleton is induced by altered foraging regime in a South American cichlid
Authors: Gilbert Michelle , Kwiatkowski Alexandria J. , Woodburn Ciara M. , Piggott Sofia N. , Haridy Yara , Aiello Brett R. , Craig Albertson R. , Stewart Thomas A. 
Published: September 2024

ABSTRACTThe fins of fishes are remarkably diverse, and this variation is tied to the ecology and locomotor mode of a species. While numerous genetic factors are known to pattern fins in development, it is unclear how developmental plasticity shapes the fin skeleton. Here, we analyze the cichlidSatanoperca daemon, raised under three distinct feeding regimes, and show that plasticity is pervasive across the pectoral fin skeleton with foraging mode impacting patterning of both the endoskeleton and dermal skeleton. Radials and fin rays were µCT scanned and analyzed using a combination of linear measures and geometric morphometrics. Anteroposterior patterning of both radials and fin rays are affected by feeding regime. Notably,S. daemonpectoral fin rays show distinct patterns of fin ray branching between treatments, suggesting altered fin stiffness. We argue that the observed changes in the fin likely reflect developmental plasticity resultant from altered swimming behaviors when fishes are challenged to forage in different ways. These data show how non-genetic mechanisms can shape both the endoskeleton and dermal skeleton of fins, and that foraging mode can induce plastic changes in skeletal elements that do not directly interface with food items.
A risk based approach to the principal–agent problem
Authors: Djehiche Boualem , Helgesson Peter 
Published: September 2024

PurposeWe aim to generalize the continuous-time principal–agent problem to incorporate time-inconsistent utility functions, such as those of mean-variance type, which are prevalent in risk management and finance.Design/methodology/approachWe use recent advancements of the Pontryagin maximum principle for forward-backward stochastic differential equations (FBSDEs) to develop a method for characterizing optimal contracts in such models. This approach addresses the challenges posed by the non-applicability of the classical Hamilton–Jacobi–Bellman equation due to time inconsistency.FindingsWe provide a framework for deriving optimal contracts in the principal–agent problem under hidden action, specifically tailored for time-inconsistent utilities. This is illustrated through a fully solved example in the linear-quadratic setting, demonstrating the practical applicability of the method.Originality/valueThe work contributes to the existing literature by presenting a novel mathematical approach to a class of continuous time principal–agent problems, particularly under hidden action with time-inconsistent utilities, a scenario not previously addressed. The results offer potential insights for both theoretical development and practical applications in finance and economics.
Exploring the critical attributes of robot chef restaurants and their impact on customer perceived value: a mixed-methods study
Authors: Gong Jinhong , Guan Xinhua , Huan Tzung-Cheng 
Published: September 2024

Purpose
This study aims to explore the key attributes of robot chef restaurants and their influencing factors from the perspective of customers and analyzes how these key attributes affect customer perceived value.

Design/methodology/approach
A mixed-methods research design was used in this study. Using 473 online reviews and ratings (Study 1), the research summarized customers’ evaluations on three types of attributes (environment, service and food) and identified the key attributes along with their influencing factors. Subsequently, through field questionnaires (Study 2) involving 269 actual customers, structural equation modeling was used to analyze how the identified key attributes and their influencing factors impact customer perceived value.

Findings
This study reveals that customers in robot chef restaurants prioritize food attributes, particularly valuing food authenticity alongside food quality. In contrast to traditional restaurants, customers’ evaluations of food attributes in robot chef restaurants are significantly influenced by the competence of robot chefs. Notably, customers’ negative attitudes toward robots diminish the positive effects on both food quality and food authenticity.

Practical implications
To enhance customer perceived value, robot chef restaurants should concentrate on food attributes. They can achieve this by fostering a high-quality, authentic food experience through the elevation of robot chefs’ competence and by providing customer education.

Originality/value
This study expands research on the customer experience in robotic restaurants by proposing an integrated model determining factors that affect the perceived customer value.
Cognitive diversity and team viability: the mediating role of transactive memory and moderating of technology integration
Authors: Arce-López Paola S. , Ruiz-Moreno Antonia , Cabeza-Pullés Dainelis 
Published: September 2024

PurposeThis study advances research on cognitive diversity from the perspective of public employees by studying the effect of cognitive diversity on team viability, the mediating effect of transactive memory systems (TMS) and the moderating effect of technology integration.Design/methodology/approachWe used SmartPLS to analyze a unique data set from 193 public employees. The information was collected through an online questionnaire administered by the LimeSurvey Professional platform. In addition to analyzing the data through partial least squares structural equation modeling with higher-order latent variables, we analyzed mediating and moderating effects.FindingsThe results show that TMS act as partial mediators between cognitive diversity and team viability. Although technology integration (for both external diffusion and internal integration) moderates this relationship to mitigate negative effects, technological infrastructure does not.Originality/valueThis study expands previous research on TMS and technology integration. Our findings support the significance of TMS and technology integration in a context of cognitive diversity, identify ways to develop good management behavior and assess the results of these practices for team viability. We recommend that public managers in contexts of cognitive diversity work to create effective workplace environments. Training programs can foster TMS capabilities and support implementation of technology integration to improve team viability and results for public service delivery to citizens.
An empirical analysis of stock market participation: from an Islamic perspective
Authors: Parvin S.M. Riha , Panakaje Niyaz , Sheikh Niha , P. Mahammad Thauseef , Irfana Shakira , Kulal Abhinandan , V. Musla , Shahid Mahammad , N.M. Abdul Basith , Nihal Mohammad 
Published: September 2024

Purpose
In the verge of assessing Muslims’ participation in stock market, present study delved into evaluating the influence of Islamic religiosity (IR) on Muslim investor’s financial engagement factors with respect to stock market (i.e. financial literacy [FL], Islamic financial literacy [IFL], behavioural factors [BF], Shariah compliance [SC], technology adoption [TA] and institutional support [IS]), stock market participation (SMP) and financial well-being (FWB). Further, this study aims to examine the mediating role of IFL, TA and SMP and moderating role of IS.

Design/methodology/approach
Using a mixed-methods approach, a structured survey questionnaire was administered and responses have been collected from 319 Muslim investors from South India using stratified random sampling. Further, data was analysed using SPSS 20.0 and AMOS 20.0 by implementing one-way ANOVA, measurement model and structural equation model to assess the differences, mediating and moderating roles.

Findings
In this study, it is discovered that IR significantly impacts Muslim investor’s financial engagement factors, SMP and FWB. Further, it is explored that IFL accelerates the impact of FL and SC on SMP. The results also demonstrated the intervening role of TA in enhancing SMP through BF and the mediating role of SMP among Muslim investors with strong IR to attain and enjoy FWB. Interestingly, our study also argued that when the IS is more, the effect of IR on SMP is high.

Research limitations/implications
Geographical boundaries are restricted to India, where the study proposes future studies in Islamic countries to better understand the religious belief system of the investors, as SC may vary in different countries.

Practical implications
In accordance with the results, it is recommended that the regulatory bodies and institutions intervene, support and incorporate IFL and also provide user-friendly Tec platforms to monitor and filter stocks and financial products for SC.

Social implications
The present study intends to tackle the misconception of Islamic values with respect to participating in the stock market and recommends to undertake policy and regulatory framework to ensure the inclusive development of this community.

Originality/value
To the best of the authors’ knowledge, no studies so far have pondered on the mediating role of SMP in enhancing the effectiveness of IR on their FWB. Further, this study collectively examines the influence of IR on various financial engagement factors affecting SMP leading to FWB.
Do we pay based on our past travel experience? A moderated mediation model of tourists’ willingness to pay
Authors: Hoang Le Nguyen , Tung Le Thanh 
Published: September 2024

PurposeThis study aims to test the first and second-stage moderating effects of tourists’ past travel experiences on the relationships between national responses, destination trust and tourists’ willingness to pay in the post-pandemic recovery era.Design/methodology/approachThe proposed model was tested with a sample of 398 tourists in Vietnam. The path analysis was applied to investigate the mediating and moderating effects.FindingsThe findings emphasise the mediating effect of destination trust in the relationships between national responses and tourists’ willingness to pay. With the moderating effect of past travel experience, all the first-stage indirect effects are significant, but the second-stage indirect effects are significant only at a high level of past travel experience.Originality/valueThis study provides theoretical implications for solving the puzzle about the paradox of trust in the government’s responses in the post-pandemic era. Practical implications for destination marketing organisations in the post-pandemic recovery era are then discussed.
Institutional work aimed at increasing employment orientation in mental health services
Authors: Skogstad Line Fossum 
Published: September 2024

PurposeThe importance of employment in recovery from mental health illness has led to broad recognition of the integration of employment-oriented support into mental health treatment. However, there is variation in the extent to which an employment orientation permeates healthcare services. This article explores how managers and advisors in health and welfare services in Norway function as “change agents”, who work to increase an employment orientation in mental health services.Design/methodology/approachThe empirical material consists of 20 interviews with change agents in health and welfare organisations. They work to implement a model – individual placement and support – to integrate an employment orientation in healthcare services. The findings are analysed using the framework of “institutional work” to elucidate the strategies used by change agents.FindingsThe findings underscore a consensus on the health advantages of employment and that employment-oriented support belongs in mental health treatment. However, this concept requires further cultivation within healthcare services, with individual actors playing a key role as change agents. Depending on the stage of the various organisations in the change process and the actors’ positions within the institutional context, the actors engaged in both creative and maintenance institutional work.Practical implicationsThe article´s findings are significant for how health organisations can work to achieve desired changes.Originality/valueThis article contributes to the literature on collaboration and implementation of employment-oriented practices in healthcare by directing attention to the dynamics of organisational change processes and the efforts of individual actors to promote change.
European football club market value and sporting performance: the moderating effect of player transfers, fans engagement and coaching changes
Authors: Hamdi Khalfaoui , Mohamed Amine Nabli , Hassan Guenichi 
Published: September 2024

PurposeThis paper investigates the relationship between sporting performance and the market value of European football clubs, with a particular focus on the moderating effect of player transfers, fan engagement and coaching changes.Design/methodology/approachUsing a Cross-Sectional Augmented Auto Regressive Distributed Lagged Model (CS-ARDL), we analyze a decade of data (2013–2023) from fourteen prominent clubs across ten European leagues.FindingsOur findings confirm a strong positive correlation between sporting performance and market value in European football clubs. Furthermore, the research reveals that strategic player transfers and high fan engagement significantly amplify the positive impact of on-field success on a club's valuation. Interestingly, coaching changes do not exhibit a significant moderating effect on this relationship.Research limitations/implicationsThese findings carry significant economic implications for the football industry, underscoring sporting success as not only a driver of economic growth and social development but also a vital source of funding for clubs seeking to further invest in talent, infrastructure and fan engagement initiatives.Originality/valueThis study makes a novel contribution to the existing literature by providing a comprehensive analysis of the intricate relationship between sporting performance, market value and the moderating roles of player transfers, fan engagement and coaching changes within the European football landscape. Moreover, the research offers unique insights into investor behavior and the factors influencing investment decisions, enriching our understanding of the complex dynamics driving the football market.
Water security and sustainability issues in Ghana’s Pra River Basin: an introduction – projected usefulness of artificial intelligence
Authors: Nti Emmanuel Kwame , Kranjac-Berisavljevic Gordana , Doke Dzigbodi Adzo 
Published: September 2024

Purpose The aim of this paper is to determine whether the dominant integrated water resources management (IWRM) paradigm within which the Pra River Basin is managed holds the key to address the current water security and sustainability issues in Southwestern Ghana.Design/methodology/approach This study employed a literature review developed based on water security and sustainability studies as well as normative scenarios from the broad scenario planning methodology. The study builds on Wæver’s Theory of Securitization and the Utilitarian theory to protect water bodies through the use of artificial intelligence (AI).Findings Insights on introducing innovative environmental sustainability technology are presented and propose the Pra-integrated smart water security management decision-making system that uses visual inspections, noise sensors, the potential of hydrogen (pH) probe sensor, real-time collection of hydrological data (streamflow) and wireless transmission of the data in real-time at the basin level. This serves as a robust tool for managing the basin’s sustainable development ecosystem by using AI to protect water bodies against illegal mining.Originality/value The proposed innovative environmental technology which is the first of its kind is meant to gain a better understanding of pollution incidents and respond quickly to them by integrating AI and Internet of Things (IoT) technologies with traditional IWRM practices. This addresses water security in the Pra Basin, supports policy development and innovation, strengthens the goal of the government to protect water resources against pollution and contributes to the African Water Vision and the United Nations’ Agenda 2030 Sustainable Development Goals 3 and 6.
Experimental analysis of the bond-slip characteristics between CFRP and natural stone masonry units
Authors: Mohamed Djeffal , Abdelghani Merdas , Taha Hocine Douara 
Published: September 2024

Purpose
Although the reinforcement of concrete and brick masonry with fiber-reinforced polymer (FRP) has been extensively researched, its application and impact on natural stone, especially in historic preservation, have received less attention. This study aims to examine the bond-slip characteristics of carbon fiber-reinforced polymer (CFRP) with two types of natural stone masonry, aiming to enhance their effectiveness in reinforcing historic structures. The stones studied include one from the Chouf-Lekdad region (A) and another from a historic structure in Sétif City (B). Both stones were strengthened using CFRP and carbon fiber fabric (CFF) through near-surface mount (NSM) and external bonding (EBR) techniques.

Design/methodology/approach
The interaction was assessed during the pull-out test by analyzing the stress transfer mechanisms, adhesion and deformation. This study also examines the effects of the following parameters on the bond between CFRP and stone: type of stone (A and B), type of reinforcement (plat CFRP and CFF), various notch shapes and sizes (bp, tp and Lb), and reinforcement techniques (NSM and EBR).

Findings
This study demonstrated the practicality and effectiveness of enhancing natural stone masonry of old buildings by integrating NSM and EBR techniques with CFRP. With a bond length of 30 mm, the pull-out force correlates with the strength of the stone. This indicates the importance of stone strength in obtaining better adhesion. The CFF–resin interface is more cohesive than the CFRP plate–resin interface because the resin penetrates the flexible CFF strip, ensuring better adhesion. In contrast, the CFRP plate interface is rigid and smooth. The results suggest that natural stone–CFRP adhesion is more effective than CFRP bonded to concrete and brick masonry due to the stone's strong resistance.

Originality/value
This experimental investigation provides new study into the bond-slip behavior of CFRP-reinforced natural stone masonry, filling the gap in existing research. The findings offer useful direction for creating FRP strengthening solutions that are specifically adapted to the properties of natural stone used in historic constructions. This study helps to improve preservation procedures by guiding the selection of reinforcing techniques, such as NSM versus EBR, and finding ideal bond lengths. This work's novelty stems from its ability to improve the structural integrity of culturally significant buildings while preserving their historical authenticity.
Embracing plant–plant interactions—Rethinking predictions of species range shifts
Authors: Sanczuk Pieter , Landuyt Dries , De Lombaerde Emiel , Lenoir Jonathan , Lorer Eline , Luoto Miska , Van Meerbeek Koenraad , Zellweger Florian , De Frenne Pieter 
Published: September 2024

Abstract

Interactions among plants are changing across the globe resulting from a multitude of changes in the environment. Obtaining accurate predictions of plant species' range dynamics requires us to account for plant–plant interactions, but this remains challenging using the existing species distribution modelling (SDM) techniques.

Advanced SDM techniques facilitate the integration of plant species interactions based on species‐to‐species associations. However, for uncharted environmental conditions in which the formerly derived species' correlations potentially no longer hold, a more process‐based alternative is expected to become increasingly relevant.

We first review the most common SDM techniques that integrate plant–plant interactions and then present the concept for a novel map product: a spatial plant–plant interaction index (PII) depicting the link between a focal species’ performance and the trait signature of the interacting vegetation. The latest developments in remote sensing and the increasing availability of vegetation plot data facilitate PII mapping based on vegetation trait–environment relationships.

Synthesis: PII mapping holds the potential to advance next‐generation biogeographical analyses as it can serve as a pivotal missing covariate layer necessary for the integration of plant–plant interactions into SDM applications. This data product adds flexibility to the ecologists’ toolbox to analyse species range shifts and the formation of novel communities as a response to multiple environmental changes.