bluuebunny/crossref_metadata_2025_split huggingface dataset:
Properties of CaLa4(Zr0.05Ti0.95)4O15 thin films by RF magnetron sputtering
Authors: Hsu Cheng-Hsing , Liu Jen-Chieh , Tseng Ching-Fang , Hsieh Wan-Yu , Yang Yu-Han , Chou Po-Heng , Chang Chia-Hsien 
Published: December 2016

Abstract
CaLa4(Zr0.05Ti0.95)4O15 thin films deposited on n-type Si(100) substrates at different substrate temperatures and radio-frequency (RF) powers were investigated. The structural and morphological characteristics analyzed by X-ray diffraction (XRD), atomic force microscopy (AFM), and scanning electron microscopy (SEM) were found to be affected by substrate temperature (150–300 °C) and RF power (200–300 W). Highly oriented CaLa4(Zr0.05Ti0.95)4O15 (110) perpendicular to the substrate surface was identified for all of the deposition conditions. The XRD showed that the deposited films exhibited a polycrystalline microstructure. As the RF power and substrate temperature increased, the quality of the CaLa4(Zr0.05Ti0.95)4O15 thin films improved, and the kinetic energies of the sputtered atoms increased, resulting in a structural improvement of the deposited CaLa4(Zr0.05Ti0.95)4O15 thin films. The optimum conditions for the growth of CaLa4(Zr0.05Ti0.95)4O15 thin films in this study were a RF power of 300 W and substrate temperature of 300 °C. A high dielectric constant of 46.2 (f = 1 MHz), dissipation factor of 0.049 (f = 1 MHz) and a low leakage current density of 7.3 × 10−7 A/cm2 in an electrical field of 100 kV/cm were obtained for the prepared films.
Surface modification of carbon nanohorns by helium plasma and ozone treatments
Authors: Lin Zaw , Iijima Toru , Karthik Paneer Selvam , Yoshida Mitsunobu , Hada Masaki , Nishikawa Takeshi , Hayashi Yasuhiko 
Published: December 2016

Abstract
In this paper, we describe the effects of helium plasma and ozone treatments on the dispersibility of carbon nanohorns (CNHs) in water. The experimental setups have been designed to efficiently generate helium plasma and ozone by dielectric barrier discharge at atmospheric pressure. After being treated with ozone, the oxygen-containing functional groups were introduced to the surface of CNHs, and are responsible for better dispersion. Helium plasma treatment was performed separately and it resulted in hydroxyl functional groups on the surface of CNHs. It was also found that the sizes of CNHs in water were smaller after ozone treatment. However, plasma-treated CNHs were bigger than ozone treated CNHs. The dispersed CNHs modified by ozone treatment were stable for more than three months without precipitation. In contrast, though helium plasma treatment introduced hydroxyl groups to the surface of CNHs, the dispersibility decreased and the flocculation of CNHs was observed in a few minutes.
Indium(III) Triflate‐Catalyzed Efficient Prins‐Type Cyclization of β‐Allenols and Aldehydes
Authors: Han Yulin , Tang Xinjun , Cheng Jiajia , Ma Shengming 
Published: December 2016

AbstractWe report here an indium(III) triflate (In(OTf)3)‐catalyzed Prins‐type cyclization of disubstituted β‐allenols in the presence of aldehydes in dichloromethane (CH2Cl2) affording different 3,6‐dihydro‐2H‐pyran at room temperature or 45 °C. The high efficiency of the reaction and easily available nature of the starting materials/catalyst make it useful in synthesizing different dihydropyran derivatives. A rationale for the formation of all the products was proposed.magnified image
Synthesis and Properties of Hydrazino Amino Acyclic Carbenes of Gold(I), Platinum(II), Palladium(II) and Rhodium(III)
Authors: Tšupova Svetlana , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: December 2016

AbstractThe nucleophilic addition of protected and substituted hydrazine derivatives to isonitrile complexes of gold(I), platinum(II), palladium(II) and rhodium(III) provides the corresponding hydrazino amino acyclic carbene complexes. These are characterized by their spectroscopic data, four different X‐ray single crystal structure analyses and their catalytic activity in the gold(I)‐catalyzed cycloisomerization of N‐propargylcarboxamides to alkylideneoxazolines is investigated.magnified image
Synthesis of 3‐Formylfurans via a Silver(I)‐Catalyzed Epoxide Ring‐Opening/1,2‐Acyl Migration/Cyclization Cascade
Authors: Wang Jing , Shen Chen , Wang Tao , Mo Sheng , Li Xingxin , Zhang Zunting 
Published: December 2016

AbstractBy the design of suitable starting materials, a silver(I)‐catalyzed epoxide ring‐opening/1,2‐acyl migration/cyclization cascade has been developed, which allowed us to systematically prepare unsymmetrical 3‐formylfurans. Various 3‐formylfurans were prepared in good to excellent yields. In addition, the distinct fluorescence properties of 3‐formylfurans in solution and the solid state are disclosed.magnified image
Dual Gold Catalysis: Synthesis of Fluorene Derivatives from Diynes
Authors: Bucher Janina , Wurm Thomas , Taschinski Svenja , Sachs Eleni , Ascough David , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: December 2016

Abstract1,5‐Diyne systems bearing one terminal and one benzyl‐ or allyl‐substituted alkyne attached to an aromatic backbone were converted in the presence of a gold catalyst. In a dual gold‐catalyzed process, gold vinylidenes are formed that selectively undergo formal CH insertion into the C(sp2)–H bond of the offered unsaturated systems. If H atoms are present in the propargylic position, a subsequent isomerization to the aromatic system takes place leading to 9H‐fluorene and 11H‐benzo[b]fluorene derivatives as final products. In the case of a quaternary carbon in the propargylic position no further aromatization is observed and 10H‐benzo[b]fluorene derivatives are obtained in high yield.magnified image
Total Synthesis of Viniferifuran, Resveratrol‐Piceatannol Hybrid, Anigopreissin A and Analogues – Investigation of Demethylation Strategies
Authors: Vo Duc Duy , Elofsson Mikael 
Published: December 2016

AbstractResveratrol‐based natural products constitute a valuable source of unique compounds with diverse biological activities. In this report we investigate demethylation strategies to minimize formation of cyclized and dimerized products during the synthesis of viniferifuran and analogues. We found that boron trichloride/tetra‐n‐butylammonium iodide (BCl3/TBAI) is typically more effective than boron tribromide (BBr3). Based on these findings we carried out the first syntheses of dehydro‐δ‐viniferin, resveratrol‐piceatannol hybrid and anigopreissin A. In addition, we have developed a short and efficient route to viniferifuran that was obtained in 13% yield over six steps.magnified image
A Modulator‐Induced Defect‐Formation Strategy to Hierarchically Porous Metal–Organic Frameworks with High Stability
Authors: Cai Guorui , Jiang Hai‐Long 
Published: December 2016

AbstractThe pore size enlargement and structural stability have been recognized as two crucial targets, which are rarely achieved together, in the development of metal–organic frameworks (MOFs). Herein, we have developed a versatile modulator‐induced defect‐formation strategy, in the presence of monocarboxylic acid as a modulator and an insufficient amount of organic ligand, successfully realizing the controllable synthesis of hierarchically porous MOFs (HP‐MOFs) with high stability and tailorable pore characters. Remarkably, the integration of high stability and large mesoporous property enables these HP‐MOFs to be important porous platforms for applications involving large molecules, especially in catalysis.
A mixed‐ligand copper(II) complex that inhibits growth and induces apoptosis by DNA targeting in human epithelial cervical cancer cells
Authors: Ma Zhong‐Ying , Qiao Zheng , Wang Dong‐Bo , Hou Xuan , Qiao Xin , Xie Cheng‐Zhi , Qiang Zhao‐Yan , Xu Jing‐Yuan 
Published: December 2016

A new mixed‐ligand copper(II) complex, [Cu(L)(phen)]⋅MeOH (L = 4‐chloro‐2‐[(2‐hydroxyphenyl)iminomethyl]phenol), was synthesized. It belongs to the orthorhombic crystal system and Cu(II) is five‐coordinated in a seriously distorted square pyramidal geometry. DNA binding experiments confirmed an intercalative mode of interaction of the complex with calf thymus DNA. In a DNA cleavage experiment with the complex, as hydrogen peroxide was involved, oxidative DNA cleavage occurred and double‐stranded breaks even appeared at certain concentration. The strong interaction with bovine serum albumin suggested that the complex might be transported by protein. The complex exhibited more significant cytotoxicity in HeLa cells (IC50 = 0.46 ± 0.01 μM) for 48 h, compared with cisplatin (10.61 ± 0.86 μM). This work indicated that the complex could induce apoptosis in a dose‐dependent manner and was associated with cell cycle arrest to some extent. Being consistent with the results of DNA cleavage experiment, comet assay indicated that the complex induced severe DNA fragmentation. The results showed the production of reactive oxygen species increased with increasing concentration of the complex. The complex was suggested to be capable of promoting HeLa cell apoptosis through an oxidative DNA damage pathway.
Iron(III) diacetylmonoxime‐2‐hydrazinopyridine complex: A new prospective antitumor drug
Authors: Saad Entsar A. , Hassanien Mohamed M. , Elneely Enas A. 
Published: December 2016

Because of the side effects and drug resistance of cisplatin, a basic clinically approved chemotherapeutic drug, a new attempt is reported to develop a novel antitumor drug based on complexation of iron metal ion with organic moiety that may be effective and safer. A newly synthesized iron(III) diacetylmonoxime‐2‐hydrazinopyridine complex was tested firstly for its cytotoxicity and superoxide dismutase (SOD)‐mimic activity in vitro then for its antitumor activity against Ehrlich ascites carcinoma (EAC) and the related biochemical alterations in vivo in comparison with cisplatin. The complex showed 80.88% SOD‐mimic activity and IC50 of 2.6 μg ml−1. In EAC‐bearing mice, in a dose‐dependent manner, Fe(III) complex treatment exhibited significant hematological profile improvements, tumor volume, viable cell count and hepatic lipid peroxidation level decreases, life span extension, hepatic glutathione and total antioxidant capacity levels enhancements, hepatic SOD and catalase activities augmentations, liver function tests alterations attenuations, and hepatocyte nucleic acids content normalization. Thus, the Fe(III) diacetylmonoxime‐2‐hydrazinopyridine complex is a novel, promising, less toxic antitumor agent. Its killing of tumor cells may be via a reactive oxygen species scavenging mechanism.
Synthesis, characterization and anticancer activity of a series of curcuminoids and their half‐sandwich ruthenium(II) complexes
Authors: Li Peiyuan , Su Wei , Lei Xiaolin , Xiao Qi , Huang Shan 
Published: December 2016

A series of curcuminoids (L1–L7) and their corresponding (η6‐p‐cymene)RuII(Cur)Cl complexes (1–7) were synthesized and characterized using 1H NMR spectroscopy, elemental analysis and high‐resolution electrospray ionization mass spectrometry. The molecular structures of L2, L4, 1 and 4 were determined using single‐crystal X‐ray diffraction analysis. The stability of 1–7 was investigated by monitoring their UV profiles. The compounds were further evaluated for their in vitro antiproliferative activities against the HepG2 human liver and HeLa human cervical cancer cell lines and HEK‐293 T noncancerous cell line.
Fine needle aspiration in the diagnosis and classification of hepatoblastoma
Authors: Vlajnic Tatjana , Brisse Hervé J. , Aerts Isabelle , Fréneaux Paul , Cellier Cécile , Fabre Monique , Klijanienko Jerzy 
Published: December 2016

BackgroundDiagnosis of hepatoblastoma (HBL) is based on characteristic clinical and radiological presentation, young age and marked elevation of serum α‐fetoprotein (aFP). Fine needle aspiration (FNA) technique is successfully used in the diagnosis of hepatoblastoma. To evaluate the value of FNA in the diagnosis and subtyping of HBL, we report our experience correlated to histological sections (core needle biopsy, CNB).MethodsFrom 1991 to 2015, 21 cases from 20 patients were cytologically diagnosed as HBL. The patients were 15 males and 5 females, mean age being 3 years, and median age being 2 years and 4 months. Serum aFP levels ranged from negative to 1,285,000 ng/ml. We defined cytological criteria to diagnose fetal, embryonal, mesenchymal, and small cell undifferentiated components.ResultsThe accurate cytological diagnosis of HBL was made in all cases; 8 cases exhibited a single component and 13 cases exhibited two or more components. Fetal and embryonal components were seen in 18 and 13 cases, respectively, and small cell undifferentiated component was seen in one case. Mesenchymal component was seen in 12 cases. Comparing cytology and histology, identical components were identified on both, FNA and CNB in 14 cases. When analyzing only the presence of epithelial components, 17 cases were concordant in both techniques.ConclusionFNA allows to accurately diagnose HBL and recognize its histological subtypes. On the basis of high concordance between cytological and histological diagnosis, FNA is validated as an alternative diagnostic method to CNB. Diagn. Cytopathol. 2017;45:91–100. © 2016 Wiley Periodicals, Inc.
Identification of porcine relaxin in plasma by liquid chromatography‐high resolution mass spectrometry
Authors: Wong April S. Y. , Ho Emmie N. M. , Kwok W. H. , Leung Gary N. W. , Shen Yuehong , Qi Robert Z. , Yue Samuel K. , Wan Terence S. M. 
Published: December 2016

Relaxin (RLX) has demonstrated diverse pharmacological effects in various scientific and clinical studies. The emergence of porcine relaxin (pRLX) has raised concerns on the doping potential of pRLX. There have also been speculations in the horseracing industry on its covert use. To control the abuse of pRLX in equine sports, a method to detect pRLX effectively and to provide its unequivocal identification in equine biological samples is required. This paper reports on the detection and confirmation of pRLX in equine plasma by liquid chromatography‐high resolution mass spectrometry. pRLX was isolated from equine plasma by immunoaffinity purification using anti‐pRLX antibody‐coated magnetic beads. Anti‐pRLX antibody was generated in‐house by purifying antisera from rabbits immunized with pRLX. The isolated pRLX was subjected to reduction of their disulfide bonds to obtain their respective A‐ and B‐chains. The extracts were then further purified and concentrated prior to reversed‐phase LC separation and high resolution accurate mass measurement. As detection of the A‐chains was far more sensitive than that of the B‐chains, the A‐chain of pRLX was set as the targets for detection and confirmation. The limit of detection for pRLX was around 0.005 ng/mL (~ 0.86 fM) and the limit of confirmation was around 0.02 ng/mL (~ 3.4 fM). It was observed that method sensitivity was improved at least 5‐fold by using an EASY‐spray column and emitter in place of the conventional ESI source. The applicability of this method was demonstrated by the identification of pRLX and its metabolites in equine plasma obtained after subcutaneous administration. To our knowledge, this is the first report of a validated mass spectrometry method for the unequivocal confirmation of pRLX in any biological fluid. Copyright © 2016 John Wiley & Sons, Ltd.
Moving beyond the concept of “primary forest” as a metric of forest environment quality
Authors: Bernier P. Y. , Paré D. , Stinson G. , Bridge S. R. J. , Kishchuk B. E. , Lemprière T. C. , Thiffault E. , Titus B. D. , Vasbinder W. 
Published: December 2016

AbstractThe United Nations Food and Agriculture Organization (FAO) has been reporting country‐level area in primary forests in its Global Forest Resource Assessment since 2005. The FAO definition of a primary forest (naturally regenerated forest of native species where there are no clearly visible indications of human activities and the ecological processes are not significantly disturbed) is generally accepted as authoritative and is being used in policy making. However, problems with this definition undermine our capacity to obtain globally coherent estimates. In addition, the current reporting on primary forests fails to consider the complementarily of non‐primary forests toward the maintenance of ecosystem services. These issues undermine the appropriate tracking of changes in primary and non‐primary forests, and the assessment of impacts of such changes on ecosystem services. We present the case for an operational reconsideration of the primary forest concept and discuss how alternatives or supplements might be developed.
Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles
Authors: Suñer S. , Gowland N. , Craven R. , Joffe R. , Emami N. , Tipper J. L. 
Published: December 2016

AbstractIn the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultrahigh molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of this study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. This study revealed that low concentrations of GO nanoparticles (0.5 wt %) do not significantly alter the wear performance of UHMWPE. In contrast, the addition of higher concentrations (2 wt %) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not show any adverse effects on L929 fibroblast and PBMNC viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not significantly affect the inflammatory response to wear particles. Further work is required to optimize the manufacturing processes to improve the mechanical properties of the nanocomposites and additional biocompatibility testing should be performed to understand the potential clinical application of these materials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 183–190, 2018.
Genomic data integration in chronic lymphocytic leukemia
Authors: Fernández‐Martínez Juan Luis , deAndrés‐Galiana Enrique J. , Sonis Stephen T. 
Published: December 2016

AbstractBackgroundB‐cell chronic lymphocytic leukemia (CLL) is a heterogeneous disease and the most common adult leukemia in western countries. IgVH mutational status distinguishes two major types of CLL, each associated with a different prognosis and survival. Sequencing identified NOTCH1 and SF3B1 as the two main recurrent mutations. We described a novel method to clarify how these mutations affect gene expression by finding small‐scale signatures that predict the IgVH, NOTCH1 and SF3B1 mutations. We subsequently defined the biological pathways and correlation networks involved in disease development, with the potential goal of identifying new drugable targets.MethodsWe modeled a microarray dataset consisting of 48807 probes derived from 163 samples. The use of Fisher's ratio and fold change combined with feature elimination allowed us to identify the minimum number of genes with the highest predictive mutation power and, subsequently, we applied network and pathway analyses of these genes to identify their biological roles.ResultsThe mutational status of the patients was accurately predicted (94–99%) using small‐scale gene signatures: 13 genes for IgVH, 60 for NOTCH1 and 22 for SF3B1. LPL plays an important role in the case of the IgVH mutation, whereas MSI2, LTK, TFEC and CNTAP2 are involved in the NOTCH1 mutation, and RPL32 and PLAGL1 are involved in the SF3B1 mutation. Four high discriminatory genes (IGHG1, MYBL1, NRIP1 and RGS1) are common to these three mutations. The IL‐4‐mediated signaling events pathway appears to be involved as a common mechanism and suggests an important role of the immune response mechanisms and antigen presentation.ConclusionsThis retrospective analysis served to provide a deeper understanding of the effects of the different mutations in CLL disease progression, with the expectation that these findings will be clinically applied in the near future to the development of new drugs.
Inkjetting Plus Peroxidase‐Mediated Hydrogelation Produces Cell‐Laden, Cell‐Sized Particles with Suitable Characters for Individual Applications
Authors: Sakai Shinji , Yamamoto Yusuke , Enkhtuul Gantumur , Ueda Kohei , Arai Kenichi , Taya Masahito , Nakamura Makoto 
Published: December 2016

The authors report a method to prepare cell‐laden, cell‐sized microparticles from various materials suitable for individual applications. The method includes a piezoelectric inkjetting technology and a horseradish peroxidase (HRP)‐catalyzed crosslinking reaction. The piezoelectric inkjetting technology enables production of cell‐laden, cell‐sized (20–60 μm) droplets from a polymer aqueous solution. The HRP‐catalyzed crosslinking of the polymer in the ejected solution enables production of spherical microparticles from various materials. Superior cytocompatibility of the microencapsulation method is confirmed from the viability and growth profiles of normal murine mammary gland epithelial cells.
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Vietnamese Version of Diabetes Self‐Management Instrument: Development and Psychometric Testing
Authors: Dao‐Tran Tiet‐Hanh , Anderson Debra J. , Chang Anne M. , Seib Charrlotte , Hurst Cameron 
Published: December 2016

AbstractSelf‐management plays a vital role in diabetes management for adults with type 2 diabetes (T2DM). While there are many people with T2DM in Vietnam, clinical understanding of diabetes self‐management (DSM) in this context is limited due to the lack of a valid measurement instrument. Translation and back‐translation processes were used to translate the Diabetes Self‐Management Instrument (DSMI) into Vietnamese. Then, translation equivalence, face validity, construct validity, and internal consistency were assessed in a sample of 198 Vietnamese adults with T2DM. The Cronbach's alpha of the V‐DSMI was .92, with a number of significant inter‐item correlations. The Vietnamese version of the Diabetes Self‐Management Instrument (V‐DSMI) retained the meaning of the original English version, and the language of the V‐DSMI was clearly understandable to adults with T2DM in Vietnam. Confirmatory factor analysis supported the goodness of fit between the data and the previously identified factor structure. These results indicated that the V‐DSMI is acceptable for use with Vietnamese adults with T2DM in further practice and research. However, future studies would be beneficial to determine the test‐retest reliability and criterion validity of the V‐DSMI. © 2016 Wiley Periodicals, Inc.
Event‐triggered distributed constrained consensus
Authors: Liu Shuai , Quevedo Daniel E. , Xie Lihua 
Published: December 2016

SummaryWe consider a distributed consensus problem for continuous‐time multi‐agent systems with set constraints on the final states. To save communication costs, an event‐triggered communication‐based protocol is proposed. By comparing its own instantaneous state with the one previously broadcasted to neighbours, each agent determines the next communication time. Based on this event‐triggered communication, each agent is not required to continuously monitor its neighbours' state and the communication only happens at discrete time instants. We show that, under some mild conditions, the constrained consensus of the multi‐agent system with the proposed protocol can be achieved with an exponential convergence rate. A lower bound of the transmission time intervals is provided that can be adjusted by choosing different values of parameters. Numerical examples illustrate the results. Copyright © 2016 John Wiley & Sons, Ltd.