bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of apparent diffusion coefficient in diagnosis of rectal carcinoma
Authors: Šarošković Milica , Vuković Miloš , Stojanoski Stefan , Zorić Milica , Prvulović Bunović Nataša , Spirovski Milena , Nosek Igor 
Published: October 2024

IntroductionThe apparent diffusion coefficient (ADC) is a quantitative parameter that facilitates the detection and reliable differentiation of rectal cancer. MR differentiation between rectal carcinoma, post-radiation proctitis, and normal rectal wall with the ADC values and their comparison depending on the level of tumor markers and pathohistological characteristics of rectal carcinoma.MethodsThe retrospective study performed at the Oncology Institute of Vojvodina included 300 patients, 100 each with rectal cancer, post-radiation proctitis, and normal rectum. Mean ADC values were obtained by measuring the region of interest (ROI) of the rectal wall.ResultsRectal cancer showed lower ADC values (0.665 ± 0.086 x 10-3mm2/s) compared to both post-radiation proctitis (1.648 ± 0.268 x 10-3mm2/s) and normal rectum (1.180 ± 0.110 x 10-3mm2/s) (p&lt;0.001). No significant differences in ADC values were observed between different grades of rectal cancer (p=0.874; p&gt;0.05), depending on the presence of metastases in the lymph nodes (p=0.357; p&gt;0.05), different TN stage (p=0.196; p&gt;0.05), local spread of the tumor (p=0.312; p&gt;0.05), the presence of RAS mutation (p=0.829; p&gt;0.05) and the value of tumor markers (p=0.923; p&gt;0.05). ADC values below 1.013 x 10-3mm2/s with 100% sensitivity and 96% specificity indicate the presence of rectal cancer in relation to normal wall, with a positive predictive value of 96.1% and a negative of 100%. ADC values below 1.255 x 10-3mm2/s with 100% sensitivity and 95% specificity indicate rectal cancer in relation to post-radiation proctitis. ADC values above 1.339 x 10-3mm2/s with 87% sensitivity and 89% specificity indicate post-radiation proctitis in relation to normal wall.DiscussionThe ADC is a useful marker in differentiating between rectal cancer, post-radiation proctitis, and normal rectal wall with high sensitivity and specificity, but it cannot be used to distinguish the histological grades of rectal cancer, nor other pathohistological parameters.
DNA methylation inhibitors adverse reaction characteristic analysis: a descriptive analysis from WHO-VigiAccess
Authors: Zhou Qiang , Xie Quanlei , Liu Qiang , Wang Haojie , Zhang Zhan , Yu Zhao , Guo Qian , Lin Jie 
Published: October 2024

IntroductionDNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group of malignant hematopoietic disorders. This study evaluates the adverse drug reactions (ADRs) following the use of DNA methylation inhibitors in the World Health Organization (WHO) VigiAccess database and compares the characteristics of ADRs between the two drugs to select the drug with the minimum individualized risk for patients.MethodsThis study employed a retrospective descriptive analysis method. We compiled ADR reports for two marketed DNA methylation inhibitors for the treatment of MDS from WHO-VigiAccess. Data collected included demographic data such as age groups, gender, and regions of global patients covered by ADR reports, as well as data on the disease systems and symptoms caused by ADRs recorded in the annual reports and reports received by WHO. By calculating the proportion of ADRs reported for each drug, we compared the similarities and differences in ADRs between the two drugs.ResultsOverall, 23,763 adverse events (AEs) related to the two DNA methylation inhibitors were reported in VigiAccess. The results showed that the top 10 most common AEs were febrile neutropenia, bone marrow suppression, neutropenia, anemia, pancytopenia, leukopenia, thrombocytopenia, bone marrow failure, agranulocytosis, and hematotoxicity. The top five common types of DNA methylation inhibitor AEs were blood and lymphatic system disorders (11,178 cases, 47.0%), cardiac organ diseases (1,488 cases, 6.3%), various congenital familial genetic diseases (49 cases, 0.2%), ear and labyrinth diseases (100, 4.2%), and endocrine system diseases (57, 2.4%).ConclusionThere is no Strong correlation between DNA methylation inhibitors and ADRs. Current comparative observational studies of these inhibitors show that there are common and specific adverse reactions in the ADR reports received by WHO for these drugs. Clinicians should improve the rational use of these drugs based on the characteristics of ADRs.
Hypoglycemic activity of Garcinia mangostana L. extracts on diabetes rodent models: A systematic review and network meta-analysis
Authors: Chatatikun Moragot , Tedasen Aman , Phinyo Phichayut , Wongyikul Pakpoom , Klangbud Wiyada Kwanhian , Kawakami Fumitaka , Imai Motoki , Chuaijit Sirithip , Rachmuangfang Sarawut , Phuwarinyodsakul Siriporn , Leelawattana Rattana , Phongphithakchai Atthaphong 
Published: October 2024

BackgroundDiabetes mellitus is a significant global health issue, and alternative treatments from natural products like Garcinia mangostana L. [Clusiaceae] or GM are being explored for their potential benefits. This study focused on evaluating the hypoglycemic effects of GM on diabetic rodent models.MethodsA comprehensive search was conducted in PubMed, Scopus, and Embase for studies reporting blood glucose levels within 2 weeks as the primary outcome and changes in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) as secondary outcomes. A network meta-analysis (NMA) was performed to determine the pooled effectiveness of each intervention, estimating the weighted mean difference (WMD) and 95% confidence interval (CI) from both direct and indirect evidence. The surface under the cumulative ranking curve (SURCA) was used to rank the interventions.ResultsTen articles were identified, with nine included for quantitative analysis. All GM extracts showed greater effectiveness than the control in decreasing blood glucose levels within 2 weeks. GM at 200 mg/kg (GM200) was the top-ranked extract for reducing glucose levels beyond 2 weeks and increasing HDL-C levels. The ethanol extract of GM at 200 mg/kg (GME200) was the most effective for blood glucose reduction within 2 weeks and for TC and TG reductions. The methanol extract of GM at 200 mg/kg (GMM200) was the top-ranked extract for LDL-C reductions.ConclusionGM and its extracts demonstrated significant hypoglycemic activity and improvements in lipid profiles in diabetic rodent models, highlighting their potential as therapeutic agents for the prevention and treatment of diabetes mellitus. Further research in human trials is warranted to confirm these findings and establish clinical applications.Clinical trial registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023426254.
Comparing single- and multi-post labeling delays for the measurements of resting cerebral and hippocampal blood flow for cerebrovascular testing in midlife adults
Authors: Decker Kevin P. , Sanjana Faria , Rizzi Nick , Kramer Mary K. , Cerjanic Alexander M. , Johnson Curtis L. , Martens Christopher R. 
Published: October 2024

ObjectivesTo assess the reliability and validity of measuring resting cerebral blood flow (CBF) and hippocampal CBF using a single-post-labeling delay (PLD) and a multi-PLD pseudo-continuous arterial spin labeling (pCASL) protocol for cerebrovascular reactivity (CVR) testing.Methods25 healthy, midlife adults (57 ± 4 years old) were imaged in a Siemens Prisma 3T magnetic resonance imaging (MRI) scanner. Resting CBF and hippocampal CBF were assessed using two pCASL protocols, our modified single-PLD protocol (pCASL-MOD) to accommodate the needs for CVR testing and the multi-PLD Human Connectome Project (HCP) Lifespan protocol to serve as the reference control (pCASL-HCP). During pCASL-MOD, CVR was calculated as the change in CBF from rest to hypercapnia (+9 mmHg increase in end-tidal partial pressure of carbon dioxide [PETCO2]) and then normalized for PETCO2. The reliability and validity in resting gray matter (GM) CBF, white matter (WM) CBF, and hippocampal CBF between pCASL-MOD and pCASL-HCP protocols were examined using correlation analyses, paired t-tests, and Bland Altman plots.ResultsThe pCASL-MOD and pCASL-HCP protocols were significantly correlated for resting GM CBF [r = 0.72; F (1, 23) = 25.24, p &lt; 0.0001], WM CBF [r = 0.57; F (1, 23) = 10.83, p = 0.003], and hippocampal CBF [r = 0.77; F (1, 23) = 32.65, p &lt; 0.0001]. However, pCASL-MOD underestimated resting GM CBF (pCASL-MOD: 53.7 ± 11.1 v. pCASL-HCP: 69.1 ± 13.1 mL/100 g/min; p &lt; 0.0001), WM CBF (pCASL-MOD: 32.4 ± 4.8 v. pCASL-HCP: 35.5 ± 6.9 mL/100 g/min; p = 0.01), and hippocampal CBF (pCASL-MOD: 50.5 ± 9.0 v. pCASL-HCP: 68.1 ± 12.5 mL/100 g/min; p &lt; 0.0001). PETCO2 increased by 8.0 ± 0.7 mmHg to induce CVR (GM CBF: 4.8% ± 2.6%; WM CBF 2.9% ± 2.5%; and hippocampal CBF: 3.4% ± 3.8%).ConclusionOur single-PLD pCASL-MOD protocol reliably measured CBF and hippocampal CBF at rest given the significant correlation with the multi-PLD pCASL-HCP protocol. Despite the lower magnitude relative to pCASL-HCP, we recommend using our pCASL-MOD protocol for CVR testing in which an exact estimate of CBF is not required such as the assessment of relative change in CBF to hypercapnia.
How technical and situational cues affect impulse buying behavior in social commerce? Evidence from bored consumers
Authors: Xue Yuhan , Feng Taiwen , Wu Chong 
Published: October 2024

IntroductionWith the rise of social media and web technologies, users are increasingly spending time on browsing and purchasing on social commerce, particularly during idle moments of casual scrolling. Social commerce applications with sophisticated social features and security measures may tend to attract a significant number of highly engaged users. The purpose of this study is to find out whether customers will be interested in the content posted on the applications and generate impulse consumption when they are bored.MethodsDrawing on stimulus-organism-response framework, this paper explores how technical cues and situational cues affect impulse buying behavior in social commerce applications and the mediating impact of consumer-perceived values. Data were gathered from 395 respondents who frequently utilize and have shopping experience on social commerce applications. The PLS-SEM and fsQCA were applied to formulate and test the proposed hypotheses.ResultsThe results of PLS-SEM reveal technical cues (ease of use, visual appeal and security) and situational cues (passing time and serendipity) positively influenced impulse buying. The results of fsQCA offer six solutions of different combinations of constructs which can lead to high impulse buying.DiscussionThese findings may extend existing research on impulse buying behavior and consumer psychology, offering valuable insights for marketers. They also point towards strategies for more effectively encouraging impulse purchase in digital retail environments, particularly among consumers who are browsing out of boredom.
Strategies and goals in Emotion Regulation models: a systematic review
Authors: Martínez-Priego Consuelo , García-Noblejas Belén Poveda , Roca Pablo 
Published: October 2024

IntroductionStudies examining the role of Emotion Regulation (ER) do not consistently explain the underlying model or theory they are employing, resulting in a conflation of different strategies and goals within the ER scientific literature. This study aims to conduct a systematic review and conceptual analysis of the primary strategies and goals advocated in the ER models, theories, and frameworks. Furthermore, we explored the distinctions between the prevailing contemporary ER models and classical conceptions of emotional dynamics, such as those proposed by Aristotle, Descartes, and Darwin.MethodsAn electronic search was conducted in the Web of Science, Medline, and Scopus databases in November 2023. The key search terms used were grouped into two different topics: Emotion Regulation and Models/Theories/Frameworks. Articles were included if they reported one or more ER model in healthy individuals or emotionally disordered individuals and if they were published in a peer-reviewed journal in English in the last 5 years (from 2019 to 2023). A total of two reviewers independently assessed the titles, abstracts, and full texts. Models identified were summarized and classified based on the different ER strategies and goals.ResultsOf the 1,012 titles for initial consideration, 139 articles met the full eligibility criteria and were included for data extraction and synthesis. The review identified 10 ER models, and the most commonly used were the Process Model of Emotion Regulation and the Difficulties in Emotion Regulation. There was a great deal of homogeneity among the proposed ER strategies and goals: the cognitive dimension is the core of ER strategy, and the ER goals are primarily hedonic or instrumental in nature.DiscussionBoth Descartes and Darwin views were present in the ER models; however, some of the most significant contributions in Aristotelian proposal seem to be forgotten, such as the integration of the physical, operational, and growth dimensions (eudaimonic goals).Systematic review registrationThis systematic review was conducted in accordance with the PRISMA guidelines and was preregistered at Prospero platform (CRD42023491948).
Validation and psychometric evaluation of the French version of the recovery experience questionnaire: internal consistency and validity assessment
Authors: Le Moal Mathieu , Thurik Roy , Torrès Olivier 
Published: October 2024

BackgroundEntrepreneurs often experience high levels of stress, anxiety, and burnout due to the demanding nature of their professional activities. Therefore, recovery from work-related stress is a relevant activity for entrepreneurs. The Recovery Experience Questionnaire (REQ) is a widely used 16-item self-reported measure covering four recovery factors: psychological detachment from work, relaxation, mastery, and control. The present study addresses the validation of a French version of the REQ.MethodsA total of 1,043 French entrepreneurs from various sectors participated in this study. Internal consistency and correlations were examined to assess the psychometric properties of the French version of the REQ. Confirmatory factor analysis (CFA) was used to validate the four-factor structure of the REQ, with seven error covariances added to improve model fit.ResultsThe French version of the REQ demonstrated good internal consistency (psychological detachment: α = 0.88, relaxation: α = 0.91, mastery: α = 0.90, control: α = 0.91). CFA supported that the four-factor structure was confirmed based on the following data: RMSEA = 0.071 (95% CI [0.066, 0.077]), CFI/TLI = 0.955/0.950, SRMR = 0.050, and χ2 (108) = 593.861, p &lt; 0.001. Significant correlations were found between REQ scores and health indicators such as stress, loneliness, physical health, mental health, and sleep quality. The results confirm that the REQ is a valid and reliable measure for assessing recovery experiences among French entrepreneurs.ConclusionWe conclude that the REQ is a valid measure and a useful tool for research on entrepreneurs’ general health. Additionally, the validated French version of the REQ can be applied to other working populations, making it a versatile instrument for evaluating health and recovery in diverse occupational settings. To support this claim, we conducted the same validation analysis on a sample of 1,231 French agricultural employees, again showing that REQ is a valid and reliable measure for assessing recovery experiences.
The effect of juggling on the proprioceptive and attentional abilities among older women
Authors: Malik Jakub , Główka Natalia , Jelonek Wojciech , Maciaszek Janusz 
Published: October 2024

BackgroundAge-related changes in attentional abilities can lead to a decline in body segment awareness in space. However, studies have reported that physical activity can improve proprioception among older adults, although proven activities with this potential are limited. Juggling is a promising activity for enhancing proprioception, as it requires high levels of attention and sensory precision. The first hypothesis posited that a juggling intervention would positively impact ipsilateral and contralateral elbow joint position matching without visual input. The second hypothesis suggested a correlation between cognitive abilities and joint position sense efficiency.MethodsA total of 20 older women (mean age: 69.95 ± 4.58) participated in a repeated-measures study using a Latin square design. Measurements were taken at three time points (baseline, post-juggling, and control). Ipsilateral and contralateral elbow joint position matchings without visual or verbal feedback of accuracy were used to assess proprioception. Attention and reaction time variables were measured using the Vienna Test System protocols.ResultsAlthough significant changes were observed between baseline and subsequent time points in joint position sense accuracy, no specific effect of juggling was detected. Low and medium correlations were found between decision time and the variability of choice reaction time with contralateral accuracy. For ipsilateral accuracy, a relationship was observed only with handedness. No correlations were found between attention test scores and joint position sense accuracy.ConclusionThe study did not demonstrate a significant effect of juggling on position-matching ability. However, cognitive abilities such as decision speed and the stability of choice reaction time may play a role in enhancing position-matching in older women.Clinical trial registrationClinicalTrials.gov, identifier NCT06108713.
Work stress and competency among radiology residents: the mediating effect of resilience
Authors: Shen Lijun , Lu Yuanmei , He Yanrong , Wang Peicheng , Chen Yanhua , Li Hange , Yang Zhenghan , Zhang Jingfeng , Wang Zhenchang , Jiang Maoqing , Zheng Jianjun , Zhu Jiming 
Published: October 2024

BackgroundCompetency of health professionals stands as a fundamental element in ensuring the quality of care. Notably, work stress and resilience are found to be associated with competency of health professionals. However, the role of resilience between work stress and competency remains unexplored. This study aims to investigate competency, work stress and resilience of radiology residents, and to examine the mediating effect of resilience.MethodsA cross-sectional survey was conducted among 3,666 radiology residents from 31 provinces of China in 2021. The diagnostic radiology milestones were used to measure the competency. Results of work stress and resilience were derived from self-reports and assessment of the Connor Davidson Resilience Scale (CD-RISC) respectively. To examine the association between work stress, resilience, and competency, Spearman correlation analysis and hierarchical linear regression were employed. The mediating effect of resilience was tested by bootstrapping analysis.ResultsDescriptive statistics show that the average score (mean ± SD) of work stress, competency and resilience among radiology residents were 1.55 ± 1.53 (range from 0 to 6), 28.14 ± 13 (range from 0 to 81) and 5.97 ± 1.92 (range from 0 to 8), respectively. Work stress was negatively associated with competency (β = −0.51, p &lt; 0.001) and resilience (−0.57, p &lt; 0.001). In particular, resilience mediated the relationship between work stress and competence, and the total mediating effect was −0.49 (= − 0.57 * 0.86), accounting for 49.06% of the total effect.ConclusionWork stress is a significant contributor to competence among radiology residents. Resilience significantly mediated the association. This study highlights incorporating resilience training courses into the standardized residency training program to reduce intensive work stress and promote competency of radiology residents.
Vertigo and dizziness due to vertebrobasilar TIA: a prospective study
Authors: Neto Arlindo C. Lima , Kim Ji-Soo , Bernardo Wanderley Marques , Bittar Roseli Saraiva Moreira 
Published: October 2024

PurposeProspective studies on vascular vertigo and dizziness (VVD) due to vertebrobasilar transient ischemic attack (VBTIA) have been sparse. This study aimed to characterize clinical features, response to treatments, and prognostic factors of VVD due to VBTIA using a cohort established in 2021.MethodsWe recruited 103 patients (58 female individuals, 56.3%), with a mean age of 70.9 ± 9.3 years (range = 37–85), between January 2021 and January 2024. All patients met the diagnostic criteria of “Probable transient VVD” published by the Bárány Society. The mean interval from symptom onset to recruitment was 11.8 months (range = 0.5–72). Treatments followed the current American Heart Association–American Stroke Association's Guidelines for Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack. Patients with recurrent strokes among TIAs, and patients who were already taking an antithrombotic agent and should maintain the same regimen were excluded.ResultsImbalance (46.7%) and vertigo (39.8%) were the most frequent symptoms. The duration of attacks was &lt;1 min in 35 patients (33.9%), 1–10 min in 34 patients (33.0%), 10–60 min in 15 patients (14.6%), and &gt;60 min in 19 patients (18.5%). Trigger factors were reported in 20 patients (19.4%), which included eccentric neck position in 12 patients (11.7%), physical exercise in four patients (3.9%), positional changes in three patients (2.9%), and eccentric neck position and physical exercise in the remaining patient (0.9%). The frequency of attacks before the medication was 1 or &lt;1/month in 32 (31.0%) patients, 1–4/month in 44 (42.7%) patients, 4–8/month in 21 patients (20.4%), and daily in six patients (5.9%). The treatment regimens were aspirin in 57 patients (55.3%), clopidogrel in 19 patients (18.5%), aspirin plus clopidogrel in 25 patients (24.3%), and rivaroxaban in two patients (1.9%). The attacks were reduced by 93.2% [IC 95% (88.34, 98.06), number needed to treat: 1] during the median follow-up of 12 months (range = 2–36 months). Only seven (6.8%) patients experienced a new attack with the medication. No prognostic factors could be identified for the recurrences.ConclusionVVD due to VBTIA has a broad clinical spectrum. Secondary stroke prevention is effective in VVD due to VBTIA even though no prognostic factors could be identified for symptom recurrence.
The relationship of knowledge about Diabetes Mellitus risk factors with the healthy lifestyle among nursing students
Authors: Malini Hema , Hazira Khairunnisa , Kardila Intan Yullya , Lenggogeni Devia Putri 
Published: October 2024

Background: The incidence of Type 2 Diabetes Mellitus (T2DM) in young age groups continues to increase. Student knowledge about diabetes risk factors is still in the category of lacking so that students cannot apply healthy lifestyle implementation behaviors correctly. Purpose: The study aims to determine the relationship between knowledge and healthy living behavior in students of the Faculty of Nursing, Andalas University. Methods: The design of this study was cross sectional. The sample number was 218 students of the Faculty of Nursing and used the propotional random sampling technique. The research data was collected with DM risk factor knowledge questionnaire and healthy lifestyle application questionnaire through Google form media. Data analysis using chi-square test. Result: Researchers found that there was a relationship between knowledge of DM risk factors and the application of a healthy lifestyle (p = 0.002), where knowledge about DM risk factors was obtained in the sufficient category with the application of a low healthy lifestyle. Conclusion: Therefore, it is still necessary to increase student knowledge about diabetes mellitus risk factors.