bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembinaan Keterampilan Budidaya Ikan Hias dan Akuaskap Warga Binaan Lembaga Pemasyarakatan (LAPAS) Kelas IIA Gorontalo
Authors: Achmad Dewi Shinta , Bakti Nurqadri Syaia , Ara Tilome Apris , Ardiansyah Widiastuti , Mokoginta Meity Melani , Indarwati Anik , Kurniawati Sri Ayu Mutmainah , Nurkhozin Ahmad Ainul 
Published: September 2024

The Gorontalo Class IIA Prison inmates need skills to prepare for life after serving their imprisonment. The negative societal stigma makes it difficult for former inmates to get advisable work. This training aims to provide skills by making aquariums, arranging the aquascapes, and ornamental fish culture that are easy to develop but have high economic value. All respondents are in the productive phase, which means that after receiving training in skills for ornamental fish culture and arranging aquascapes, the inmates who leave prison can later create their jobs, thereby reducing the risk of committing criminal acts again. After this skill development, the prison inmates gained a significant increase in knowledge, which is reflected in the increase in the average post-test score of the inmates compared to the pre-test score. Based on the paired t-test results, the t-count > t-table value is obtained, so H0 is rejected, which means that the analyzed data (sample data) supports the existence of differences. An event between the two groups being compared.
Sosialisasi dan Pembentukan PIK-R Sebagai Salah Satu Icon Kampung KB di Desa Ilohungayo, Kecamatan Batudaa
Authors: Setiawan Dewa Gede Eka , Demulawa Meilan , Yunus Muhammad 
Published: September 2024

PIK-R is a forum for Family Life Preparation for Adolescents program activities that are managed from, by and for adolescents to provide information services and reproductive health counseling and family life preparation. Adolescents need reproductive health information in order to behave healthy with the opposite sex and be aware of calls to perform risky sexual behaviors. The research method used is development (Research and Development / R&D). This research was conducted in Ilohungayo Village of Batudaa District of Gorontalo Province. The population is all teenagers aged 18-25 years and unmarried as many as 56 teenagers. The sample number is 50, taken with purposive sampling techniques. The purpose of socialization and formation of PIK-R is an effort to increase knowledge to the youth in Ilohungayo village about the healthy living behavior of adolescents, especially those related to the risk of TRIAD KRR, namely sexuality, drugs, HIV and AIDS. The results of the implementation of socialization and formation of PIK-R activities are obtained several important points, where teenagers get knowledge to prepare a healthy family life in the future, teenagers can be more vigilant about the risks of TRIAD KRR, namely Sexuality, Drugs, HIV, and AIDS, and also teenagers in Ilohungayo Village can develop positive activities that are more innovative and creative in the containers that have been given.
On the Essence of the Riemann Zeta Function and Riemann Hypothesis
Authors: Wang Shisheng 
Published: September 2024

Riemann’s functional equation \(\pi^{- \frac{s}{2}}\Gamma\left( \frac{s}{2} \right)\zeta(s) = \pi^{- \left( \frac{1}{2} - \frac{s}{2} \right)}\Gamma\left( \frac{1}{2} - \frac{s}{2} \right)\zeta(1 - s)\) is valid on the vertical line \(s = \frac{1}{2} + it\). Each side is a real-valued function. The Riemann’s Xi function is also a real-valued function along the vertical line of \(s = \frac{1}{2} + it\). Through the holomorphic extensions of the Riemann zeta function, starting from the real-valued function at \(s = \frac{1}{2} + it\) into the both sides of \(\sigma < \frac{1}{2}\) and \(\sigma > \frac{1}{2}\), we can get two versions of the zeta functional equation, eq. (45). The key property of the scaling and rotational factors g(s) and g(1-s) behave as multiplicative inverses in the complex plane, eq. (48). It is deduced that the Zeta function also has multiplicative inverses, the symmetric point is at (1/2,0) in the complex plane. The moduli behave as a hyperbola. Especially, along the vertical line \(\sigma = \frac{1}{2} + it\), the amplitudes of both function g(s) and g(1-s) are equal to 1, its arguments have opposite signs. If \(\sigma \neq \frac{1}{2}\), the amplitudes of \(\zeta(s)\) and \(\zeta(1 - s)\) are not equal to each other, because of their multiplicative inversion relationship. It is deduced that the non-trivial zeros can only be on the vertical line of \(s = \frac{1}{2} + it\). A gamma function vector field is given in Appendix B, and some moduli of gamma function at special points are given. Finally, another variation of the Zeta function is provided in an integral form in Appendix D. The asymptotes behave as a c8 cyclic group for the large t values.
Gangguan Psikologis Ibu Hamil Berhubungan dengan Keberhasilan Menyusui Pada Bulan Pertama Setelah Kelahiran di Masa Pandemi COVID 19
Authors: Sukriani Wahidah , Noordiati Noordiati 
Published: September 2024

Latar Belakang: Menyusui eksklusif selama enam bulan terbukti memiliki banyak manfaat. Namun,angka cakupan ASI eksklusif masih jauh dari target. Kecemasan dan depresi merupakan gangguanpsikologis yang sering terjadi pada ibu hamil. Depresi pada ibu hamil berisiko bagi ibu dan bayi.Wanita hamil dan janin merupakan populasi berisiko tinggi selama wabah covid. Dampak lanjut dariinfeksi COVID-19 pada ibu hamil adalah munculnya kekhawatiran terkait pertumbuhan danperkembangan neonatal. Ibu dengan kecemasan dan depresi lebih sedikit yang melaksanakan inisiasimenyusu dini (IMD) dan memiliki durasi menyusui yang lebih singkat. Tujuan: penelitian inibertujuan untuk menganalisis hubungan ganggungan psikologis ibu hamil dengan keberhasilanmenyusui pada satu bulan pertama di masa pandemi covid-19 di Kota Palangkaraya. Metode:Penelitian ini merupakan penelitian analitik observasional dengan rancangan Kohort Prospektif. Sampel penelitian sejumlah 66 orang yang dibagi menjadi dua grup. Analisis penelitian menggunakanuji chi square dan Risk Relative. Hasil: Terdapat hubungan antara gangguan psikologis ibu hamildengan keberhasilan menyusui pada satu bulan pertama (p<0,05). Ibu hamil dengan risiko depresiberisiko 1,9 kali lebih tinggi untuk tidak memberikan ASI secara penuh. Kesimpulan: gangguanpsikologis berhubungan dengan keberhasilan menyusui pada bulan pertama.
Riwayat Keluarga, Status Merokok dan Aktivitas Olahraga sebagai Faktor Risiko Hipertensi
Authors: Marfu’ah Ummi , Handayani Rini , Wekadigunawan Cri Sajjana Prajna , Zelfino Zelfino 
Published: September 2024

Latar Belakang: Hipertensi adalah terjadinya peningkatan tekanan darah pada pembuluh darah arteri.Hipertensi merupakan penyakit tidak menular yang prevalensinya meningkat dari waktu ke waktu.Survei awal di Puskesmas Kecamatan Cengkareng menunjukkan adanya peningkatan kejadianHipertensi pada tahun 2016 ke tahun 2017 sebesar 3,97%. Hipertensi dapat menyebabkan penyakitjantung koroner, stroke, pre-ekslampsia, kerusakan ginjal bahkan kematian. Diperkirakan penyebabHipertensi adalah pola hidup masyarakat yang kurang baik. Tujuan: Tujuan penelitian ini untukmengetahui faktor risiko Hipertensi di Puskesmas Kecamatan Cengkareng, Jakarta Barat pada tahun2018. Metode: Desain penelitian yang digunakan adalah Cross-sectional. Populasi penelitian adalahseluruh pasien yang berkunjung di Puskesmas Cengkareng. Sampel penelitian adalah 422 pasien yangberkunjung ke Puskesmas Kecamatan Cengkareng. Pengambilan sampel menggunakan teknik simplerandom sampling. Analisis bivariat dilakukan dengan menggunakan uji Chi-Square. Hasil: Hasilanalisis bivariat menunjukkan ada hubungan antara riwayat keluarga (p-value: <0,001), statusmerokok (p-value: <0,001), dan aktivitas olahraga (p-value: <0,001) dengan kejadian Hipertensi diPuskesmas Kecamatan Cengkareng. Selain itu, tidak ada hubungan antara umur (p-value: 0,309), jeniskelamin (p-value: 0,270), dan status gizi (p-value: 0,290) dengan kejadian Hipertensi di PuskesmasKecamatan Cengkareng. Kesimpulan: Faktor risiko Hipertensi di Puskesmas Kecamatan Cengkarengpada 2018 adalah riwayat keluarga, status merokok, dan aktivitas olahraga.
Association between duration of gadget use and social development in school-age children
Authors: Yuswandi Yuswandi , Musri Musri , Resiani Bunga , Gustryanti Kiki 
Published: September 2024

Background: The prevalence of school-age children who have gadgets is around 71%, and as many as 55% of them spend time playing these gadgets by playing games. In this sophisticated age, children often focus more on gadgets so if you use gadgets excessively, it will have an impact on children's social development.
Purpose: To determine the relationship between gadget use and social development in school-age.
Method: A cross-sectional study was used for this study. The sample was school-age children (10-12 years) at Elementary School—100 people who were obtained through the total sampling technique. A questionnaire was performed for data collection. The data were analyzed by the Chi-Square statistical test.
Results: The results indicate that most of the participants had higher scores on using the gadgets with a long category (67%). However, almost half of the participants had social development with the adequate category (62%). The results of the statistical test obtained p value = 0.005 < ɑ 0.05.
Conclusion: There is a significant relationship between gadget use and social development among school-age at Elementary School.
it can be concluded that there is a significant relationship between gadget use and social development among school-age at Elementary School.
Clinical and genomic characterization of carbapenem-resistant Enterobacterales bloodstream infections in patients with hematologic malignancies
Authors: Chen Yi , Huang Jiangqing , Dong Luyan , Xu Binbin , Li Lei , Zhao Zhichang , Li Bin 
Published: September 2024

BackgroundCarbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) pose a significant risk to patients with hematologic malignancies, yet the distinct features and outcomes of these infections are not thoroughly understood.MethodsThis retrospective study examined the characteristics and clinical outcomes of patients with Enterobacterales BSIs at the Hematology Department of Fujian Medical University Union Hospital from 2018 to 2022. Whole-genome sequencing was conducted on 45 consecutive CRE BSI isolates during this period.ResultsA total of 301 patients with Enterobacterales BSIs were included, with 65 (21.6%) cases of CRE and 236 (78.4%) cases of carbapenem-susceptible Enterobacterales (CSE). CRE infections accounted for 16.9% to 26.9% of all Enterobacterales BSIs, and carbapenem-resistant Klebsiella pneumoniae (CRKP) was the predominant strain. The most frequent sequence type (ST) and carbapenemase among CRKP were ST11 (68.6%) and blaKPC-2 (80.0%), respectively. Perianal infections, multiple infection foci, and a history of multiple hospitalizations, ICU stays, and prior CRE infections were identified as risk factors for CRE BSIs. Patients in the CRE group experienced significantly higher proportions of infection-related septic shock (43.1% vs. 19.9%, P &lt; 0.0003) and 30-day all-cause mortality (56.9% vs. 24.6%, P &lt; 0.0001) compared to those in the CSE group. Patient’s age and disease subtypes, strain subtypes, and antimicrobial treatment regimens significantly influenced survival in patients with CRE BSIs.ConclusionsCRE BSIs are a frequent complication in patients with hematological malignancies undergoing treatment and are associated with poor survival rates. A comprehensive understanding of risk factors and ongoing surveillance of prevalent strains are essential for the effective management of these infections.
Successful generalization of conceptual knowledge after training to remember specific events
Authors: Houser Troy M. , Resnick Anthony , Zeithamova Dagmar 
Published: September 2024

IntroductionCategorization involves grouping information to make inferences and support novel decisions. In the laboratory, category learning tasks commonly involve trial-and-error where participants are instructed to classify stimuli and learn through feedback. Here, we tested across two experiments whether people can acquire category knowledge in an incidental manner by associating category members with other information that itself is structured, and how it compares to acquiring category knowledge directly through feedback-based classification training.MethodsSubjects were trained to remember specific associations consisting of cartoon animals paired with animal-specific background scenes. Animals presented on forest vs. mountain scenes were members of two prototype-based categories, but this was not conveyed to the participants. Spontaneous category learning was tested by asking participants to guess habitat (mountains, forests) for old and new cartoon animals without feedback.ResultsWe found that participants spontaneously acquired category knowledge, showing high categorization accuracy for new animals, comparable to a group that underwent a traditional feedback-based classification training with the same stimuli. Strategy analysis showed that the majority of participants in both groups abstracted the central tendency of the categories, albeit a somewhat larger proportion of subjects relied on memory for specific training exemplars after paired-associate learning. Partial evidence was found for the hypothesis that generalized knowledge emerged at the expense of memory for specific animal-scene associations.DiscussionThe findings show that despite the goal to remember specific information that required differentiation of stimuli within categories, subjects can spontaneously acquire category knowledge, generalizable to novel stimuli in a way comparable to traditional supervised classification training. This work provides new insights into how category learning can proceed under more naturalistic demands.
An algorithm for identifying stratigraphic piles from interpreted boreholes
Authors: Schorpp Ludovic , Straubhaar Julien , Renard Philippe 
Published: September 2024

IntroductionThe Stratigraphic Pile (SP) is one of the foundation of most geological studies. It represents, in a compact and practical way, a vertical succession of depositional events over geological time. Accurate definition of the SP is crucial for geological modeling, yet challenges arise when relying on borehole data in the absence of clear biostratigraphic indicators or chronostratigraphical data.MethodsThis manuscript introduces an algorithm designed to automatically determine the SP using borehole unit sequences. The algorithm also addresses the complexities associated with incomplete sedimentological records and subjective geological interpretations. The algorithm was tested on various datasets, taking into account differences in the number of boreholes and available information.Results and DiscussionThe efficiency of the algorithm was demonstrated through real-world applications, providing a basis for a comprehensive discussion of its advantages, limitations, and potential applications. The proposed methodology assumes that each borehole contains a single occurrence of a stratigraphic unit, taking into account possible interpretation errors and inconsistencies. The algorithm is capable of: automatically determining one or an ensemble of plausible stratigraphic sequences, identifying potential misinterpreted wells, quantifying the vertical relationships of the stratigraphic units, and assisting in the data preprocessing step and in building the geologic concept of the modeling area. In particular, this ensemble of SPs and identified inconsistencies provide valuable insights into the geological history and concepts for a particular area.ConclusionThis research contributes to the refinement of geological modeling workflows and provides a valuable tool for automatic refinement of SP selection.
Mendelian randomization analysis and validation supports MEGF9 and MLLT11 as potential targets for the treatment of varicocele and male infertility
Authors: Cai Bin , Sun Dalin , Deng Weimin , Jin Yihan , Zhao Hongle , Xing Dong , Liu Yuanyuan , Jin Baofang 
Published: September 2024

ObjectiveA growing body of research suggests a link between varicocele and male infertility (MI). However, current evidence is mainly based on retrospective studies, which are prone to interference from confounding factors and cannot establish causal relationships. Mendelian randomization (MR) studies on the causal relationship between varicocele and MI are very limited. Therefore, this study conducted a two-sample MR study to elucidate the causal effect between the two.MethodsDownload the data set GSE216907 from the GEO database, and use R software to screen differential genes in normal and varicocele tissue samples. The drug targets of Bu Shen Huo Xue Prescription (BSHXP) were derived from the Herb database. All genetic datasets were obtained using publicly available summary statistics based on individuals of European ancestry from the IEU GWAS database. MR analysis was performed using MR Egger, weighted median (WM) and inverse variance weighted (IVW) methods to assess the causal relationship between exposure and outcome and to validate the findings by comprehensively evaluating the effects of pleiotropic effects and outliers. The renal vein constriction method was used to establish a pathological model of varicocele infertility. The drug was administered continuously for 60 days and the relevant indicators of the rats were observed.ResultsObtain two therapeutic targets for varicocele through intersection analysis: MEGF9 and MLLT11, and were verified by molecular docking. MR analysis showed that MEGF9 was positively associated with MI (MR Egger, OR: 1.639, 95% CI: 1.124-2.391, P = 0.024; WM, OR: 1.235, 95% CI: 1.003-1.521, P = 0.047). MEGF9 is also positively associated with MI (IVW, OR: 1.35, 95% CI: 1.069-1.705, P = 0.012). Sensitivity analysis showed no heterogeneity and horizontal pleiotropy. The expression of MEGF9 and MLLT11 increased in the varicocele model group, while the expression decreased after treatment with low, medium, and high doses of BSHXP. In addition, the sperm number, motility, morphology, and fertility of rats in the model group were significantly lower than those in the control group (P&lt;0.05). After BSHXP treatment, all indicators were significantly better than those of the model group (P&lt;0.05).ConclusionIn conclusion, this study indirectly supports that varicocele causes MI. BSHXP inhibiting MEGF9 and MLLT11 may become a potential therapeutic target for alleviating varicocele and MI.
How does the energy consumption structure affect the green economic development? A spatial impact analysis
Authors: Zhang Shumin , Wang Jing , Guan Jiawei 
Published: September 2024

BackgroundOptimizing the energy consumption structure (ECS) is conducive to promoting the efficiency and quality of regional green economic development (GED). This paper discusses the current situation of green economic development (GED) in China and how optimizing the energy consumption structure (ECS) can promote green economic development (GED).MethodsA systematic literature search (from January 2013 to July 2024) was conducted using the keywords “green economic development” and “energy consumption structure” in the following databases: Web of Science, Embase, Science Direct, and PubMed. In this paper, the entropy method was used to measure the GED indicator system, Arcgis drawing was applied to show the current status of GED development, and the theme of this paper was investigated by constructing the basic regression model, Spatial Durbin model, mediating effect model, and moderating effect model. Two researchers independently screened and extracted data.ResultsThe analysis of empirical tests in 30 provinces yielded the following results: The overall development of China’s GED shows a fluctuating upward trend. However, there is a regional development imbalance, and the development level of the eastern region is significantly higher than that of the central and western regions. The optimization of ECS contributes significantly to the improvement of GED. And the effect of optimizing ECS on GED has an apparent spatial spillover effect. The optimization of ECS in neighboring regions also promotes the increase of GED in the region, and this feature is more obvious in the central and western regions. The spatial effect of ECS optimization on GED is shown as Central Region &gt; Western Region &gt; Eastern Region. The total effect of the upgrading of the energy consumption structure and its impact on surrounding areas is shown in the following regions: Western region &gt; Central region &gt; Eastern region. The analysis of the mechanism effect shows that upgrading industrial structure is the main mechanism for optimizing ECS on GED.DiscussionThe results show that the optimization and upgrading of ECS is the driving force behind the development of GED, and that there is a need to break down barriers between regions to promote the common development of GED, as well as to play a role in the mechanism of industrial structure.
Case report: Two siblings with very late onset of holocarboxylase synthase deficiency and a mini-review
Authors: Gaschignard Margaux , Domenach Louis , Lamireau Delphine , Guibet Claire , Roche Sandrine , Richard Emmanuel , Redonnet-Vernhet Isabelle , Mesli Samir , Lebreton Louis 
Published: September 2024

Holocarboxylase synthase (HCS) deficiency is an extremely rare metabolic disorder typically presenting as severe neonatal metabolic acidosis, lethargy, hypotonia, vomiting, and seizures. This report describes two siblings in a family with late-onset forms of HCS deficiency. The younger sister presented at the age of 11 years and manifested as acute metabolic acidosis, which promptly resolved following rehydration and biotin administration. The results of the organic urine profile confirmed multiple carboxylase deficiency, and genetic testing revealed a novel pathogenic variant in the HLCS gene (NM_000411.8) in the homozygous state: c.995A&gt;G; p. (Gln332Arg). No further decompensation was observed for her during the 3-year follow-up period. His older brother was diagnosed at the age of 23 years-old through biochemical tests, without any history of acidotic decompensation. A mini-review of HCS deficiency with late onset (&gt;1 year) or early onset (&lt;1 month) revealed that splice variants are associated with late onset, while both variants p. (Leu216Arg) and p. (Leu237Pro) are associated with early onset. However, the majority of genotypes do not show a clear correlation with the timing of HCS deficiency onset. The most significant point here is the description of extremely late-onset cases of HCS deficiency. This can prompt metabolic investigations and raise suspicion of this rare disease in cases of unexplained metabolic acidosis, even beyond early childhood.