bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using principal component analysis to improve earthquake magnitude prediction in Japan
Authors: Asencio-Cortés G , Martínez-Álvarez F , Morales-Esteban A , Reyes J , Troncoso A 
Published: September 2017

AbstractIncreasing attention has been paid to the prediction of earthquakes with data mining techniques during the last decade. Several works have already proposed the use of certain features serving as inputs for supervised classifiers. However, they have been successfully used without any further transformation so far. In this work, the use of principal component analysis (PCA) to reduce data dimensionality and generate new datasets is proposed. In particular, this step is inserted in a successfully already used methodology to predict earthquakes. Tokyo, one of the cities mostly threatened by large earthquakes occurrence in Japan, is studied. Several well-known classifiers combined with PCA have been used. Noticeable improvement in the results is reported.
The 26.3-h orbit and multiwavelength properties of the ‘redback’ millisecond pulsar PSR J1306–40
Authors: Linares Manuel 
Published: September 2017

Abstract
We present the discovery of the variable optical and X-ray counterparts to the radio millisecond pulsar (MSP) PSR J1306–40, recently discovered by Keane et al. We find that both the optical and X-ray fluxes are modulated with the same period, which allows us to measure for the first time the orbital period Porb = 1.097 16[6] d. The optical properties are consistent with a main-sequence companion with spectral type G to mid K and, together with the X-ray luminosity (8.8 × 1031 erg s−1 in the 0.5–10 keV band, for a distance of 1.2 kpc), confirm the redback classification of this pulsar. Our results establish the binary nature of PSR J1306–40, which has the longest Porb among all known compact binary MSPs in the Galactic disc. We briefly discuss these findings in the context of irradiation and intrabinary shock emission in compact binary MSPs.
A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases
Authors: Revankar Sanjay G , Baddley John W , Chen Sharon C -A , Kauffman Carol A , Slavin Monica , Vazquez Jose A , Seas Carlos , Morris Michele I , Nguyen M Hong , Shoham Shmuel , Thompson George R , Alexander Barbara D , Simkins Jacques , Ostrosky-Zeichner Luis , Mullane Kathleen , Alangaden George , Andes David R , Cornely Oliver A , Wahlers Kerstin , Lockhart Shawn R , Pappas Peter G 
Published: September 2017

Abstract

Background
Phaeohyphomycosis is infection caused by dematiaceous, or darkly pigmented, fungi. The spectrum of disease is broad, and optimal therapy remains poorly defined. The Mycoses Study Group established an international case registry of patients with proven/probable phaeohyphomycosis with the goal of improving the recognition and management of these infections.

Methods
Patients from 18 sites in 3 countries were enrolled from 2009–2015. Cases were categorized as local superficial, local deep (pulmonary, sinus, osteoarticular infections), and disseminated infections. End points were clinical response (partial and complete) and all-cause mortality at 30 days and end of follow-up.

Results
Of 99 patients, 32 had local superficial infection, 41 had local deep infection, and 26 had disseminated infection. The most common risk factors were corticosteroids, solid organ transplantation, malignancy, and diabetes. Cultures were positive in 98% of cases. All-cause mortality was 16% at 30 days and 33% at end of follow-up, and 18 of 26 (69%) with dissemination died. Itraconazole was most commonly used for local infections, and voriconazole was used for more severe infections, often in combination with terbinafine or amphotericin B.

Conclusions
Phaeohyphomycosis is an increasingly recognized infection. Culture remains the most frequently used diagnostic method. Triazoles are currently the drugs of choice, often combined with other agents. Further studies are needed to develop optimal therapies for disseminated infections.
Critical appraisal of the unmet needs in the treatment of chronic spontaneous urticaria with omalizumab: an Italian perspective
Authors: Asero Riccardo , Canonica Giorgio W. , Cristaudo Antonio , Fierro Maria T. , Girolomoni Giampiero , Marzano Angelo V. , Nettis Eustachio , Pepe Patrizia , Pigatto Paolo , Rossi Oliviero 
Published: September 2017

Purpose of review
The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeutic needs associated with omalizumab and discusses practical recommendations for its use in the management of CSU.

Recent findings
Although modern second-generation H1-antihistamines are the standard of care for patients with CSU, adjunctive treatments (including omalizumab) may be required for effective control of symptoms in many patients. Evidence from clinical trials and experience from daily clinical practice suggest that the use of omalizumab in patients with CSU who have inadequate response to H1-antihistamines remains challenging.

Summary
Based on current international guidelines, omalizumab labelling information and our experience in clinical practice, we provide treatment recommendations regarding the use of omalizumab in patients with CSU. These include: optimal treatment duration, the use of concomitant antihistamine therapy, the definition and management of disease relapse after treatment, and the management of patients with late or no response to treatment.
The RCPA Quality Assurance Program in Dermatopathology: A Retrospective Review
Authors: Peck Martyn , Beer Trevor W. , Badrick Tony , Wood Benjamin A. 
Published: September 2017

Aims:
To review the Royal College of Pathologists of Australasia (RCPA) Quality Assurance Program Dermatopathology module from 2005 to 2016 to assess diagnostic performance, changes over time, and areas of diagnostic difficulty.

Methods:
The computerized records of the RCPA Dermatopathology subspecialist module were reviewed. Cases were categorized into groups including nonneoplastic disorders, neoplasms, and cases with multiple diagnoses. The performance of participants over time in each of these categories and in more specific areas (including melanocytic and adnexal neoplasms) was assessed. Cases which showed high rates of discordant responses were specifically reviewed.

Results:
One hundred sixteen cases circulated over 10 years were evaluated. The overall concordance rate was 77%, with a major discordance rate of 7%. There was a slightly higher concordance rate for neoplasms compared with nonneoplastic lesions (80% vs. 74%). Specific areas associated with lower concordance rates included classification of adnexal tumors and identification of multiple pathologies. A spindle cell nevus of Reed yielded a 40% discordance rate, with most misclassifications indicating melanoma.

Conclusions:
The RCPA quality assurance program module has circulated a wide range of common and uncommon cases to participants over the 12 years studied, highlighting a low but important rate of major discordant responses. Melanocytic lesions, hematolymphoid infiltrates, adnexal tumors, and identification of multiple pathologies are identified as areas worthy of particular attention in quality improvement activities.
Novel Double-Needle System That Can Prevent Intravascular Injection of Any Filler
Authors: Huang Hsiang , Lin Yu-Shan 
Published: September 2017

Summary:
A new type of needle system combines 2 parts, an inner needle and an outer needle. The inner needle is used for filler injection and the outer needle acts as a guiding needle that can observe blood reflow when inserting into the vessel lumen during injection process. This new needle system can be used for all kinds of filler, providing real time monitoring for physician and preventing intravascular injection of any filler.
Spontaneous Regression of Lymphangiomas in a Single Center Over 34 Years
Authors: Kato Motoi , Watanabe Shoji , Kato Reiko , Kawashima Hiroshi , Iida Takuya , Watanabe Azusa 
Published: September 2017

Background:
A lymphangioma, also called a lymphatic malformation, is a congenital condition that frequently occurs in young children. It is classified into 3 groups depending on the size of the cysts (macrocystic, microcystic, and mixed). Spontaneous regression occurs in some cases; however, the characteristics of patients who show regression have not been studied previously. Furthermore, the types and the timing of the initial treatment are still controversial. Therefore, we statistically analyzed the occurrence of short-term spontaneous regression, patient age at original occurrence, cyst types, cyst sizes, and cyst locations in patients diagnosed with peripheral localized lymphangiomas in a single children center over 34 years.

Methods:
We retrospectively collected the data of 153 patients and reviewed the medical charts.

Results:
Spontaneous regression occurred only in macrocystic or mixed type; regression was most frequent in patients who, at the time of onset, were more than 2 years old.

Conclusions:
We concluded that elderly patients with macrocystic or mixed type lymphangioma may have to wait for treatment for over 3 months from the initial onset. Conversely, microcystic type could not be expected to show regression in a short period, and prompt initiation of the treatments may be required. The difference of the regression or not may depend on the characteristics of the lymph flow.
Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors
Authors: Sardi Natalia Fantin , Tobaldini Glaucia , Morais Rosana Nogueira , Fischer Luana 
Published: September 2017

Abstract
Sleep disorders increase pain sensitivity and the risk of developing painful conditions; however, the underlying mechanisms are poorly understood. It has been suggested that nucleus accumbens (NAc) influences sleep-wake cycle by means of a balance between adenosine activity at A2A receptors and dopamine activity at D2 receptors. Because the NAc also plays an important role in pain modulation, we hypothesized that the NAc and its A2A and D2 receptors mediate the pronociceptive effect of rapid eye movement (REM) sleep deprivation (SD). We found that 24 hours of REM-SD induced an intense pronociceptive effect in Wistar rats, which decreases progressively over a sleep rebound period. Although the level of fecal glucocorticoid metabolites increased with SD within group, it did not differ between sleep-deprived group and control group, indicating a stress response with similar magnitude between groups. The pronociceptive effect of REM-SD was prevented by excitotoxic lesion (N-Methyl-D-aspartate, 5.5 μg) of NAc and reverted by its acute blockade (Qx-314, 2%). The administration of an A2A receptor antagonist (SCH-58261, 7 ng) or a D2 receptor agonist (piribedil, 6 μg) into the NAc increased home cage activity and blocked the pronociceptive effect of REM-SD. Complementarily, an A2A receptor agonist (CGS-21680, 24 ng) impaired the reversal of the pronociceptive effect and decreased home cage activity, as it did a D2 receptor antagonist (raclopride, 5 μg). Rapid eye movement SD did not affect the expression of c-Fos protein in NAc. These data suggest that SD increases pain by increasing NAc adenosinergic A2A activity and by decreasing NAc dopaminergic D2 activity.
Protein Digestion and Quality of Goat and Cow Milk Infant Formula and Human Milk Under Simulated Infant Conditions
Authors: Maathuis Annet , Havenaar Robert , He Tao , Bellmann Susann 
Published: September 2017

ABSTRACT

Objective:
The aim of this study was to determine the kinetics of true ileal protein digestion and digestible indispensable amino acid score (DIAAS) of a goat milk-based infant formula (GIF), a cow milk-based infant formula (CIF), and human milk (HM).

Methods:
The GIF, CIF, and HM were investigated in an in vitro gastrointestinal model simulating infant conditions. Digested compounds were dialyzed from the intestinal compartment as bioaccessible fraction. Dialysate was collected in 15 to 60-minute periods for 4 hours. True ileal protein digestibility and DIAAS were determined as bioaccessible nitrogen (N) and amino acids.

Results:
N bioaccessibility from the GIF showed similar kinetics to that of HM. The CIF showed a delay in N bioaccessibility versus the GIF and HM. In the 1st hour of digestion, N bioaccessibility was 19.9% ± 3.5% and 23.3% ± 1.3% for the GIF and HM, respectively, and 11.2% ± 0.6% for CIF (P < 0.05 vs HM). In the 3rd hour of digestion, the N bioaccessibility was higher (P < 0.05) for the CIF (28.9% ± 1.2%) than for the GIF (22.5% ± 1.6%) and HM (20.6% ± 1.0%). After 4 hours, the true ileal protein digestibility of the GIF, CIF, and HM was 78.3% ± 3.7%, 73.4% ± 2.7%, and 77.9% ± 4.1%, respectively. The DIAAS for the GIF, CIF, and HM for 0- to 6-month-old infants was 83%, 75%, and 77% for aromatic AA.

Conclusion:
The protein quality is not different between the GIF, CIF, and HM, but the kinetics of protein digestion of the GIF is more comparable to that of HM than that of the CIF.
Interventions for Gait Training in Children With Spinal Cord Impairments: A Scoping Review
Authors: Funderburg Sarah E. , Josephson Hannah E. , Price Ashlee A. , Russo Maredith A. , Case Laura E. 
Published: September 2017

Purpose:
This is a scoping review of the literature on interventions for gait in individuals with pediatric spinal cord impairments.

Summary of Key Points:
Four categories of interventions were identified: orthoses/assistive devices, electrical stimulation, treadmill training, and infant treadmill stepping.

Conclusions:
Studies on orthotic intervention, electrical stimulation, and treadmill training reported benefits for various components of gait. The majority of articles (77%) were classified as levels of evidence III and IV.

Clinical Recommendations:
Each intervention targeted specific outcomes; therefore, it is important to identify individual patient characteristics and goals appropriate for each intervention to guide clinical practice. Determining the appropriate orthotic support for each child, and incorporating treadmill training or electrical stimulation, is recommended.
Determining Need for School-Based Physical Therapy Under IDEA: Commonalities Across Practice Guidelines
Authors: Vialu Carlo , Doyle Maura 
Published: September 2017

Background and Purpose:
The Individuals with Disabilities Education Act (IDEA) includes physical therapy (PT) as a related service that may be provided to help students with disabilities benefit from their education. However, the IDEA does not provide specific guidance for the provision of school-based PT, resulting in variations in practice across the United States. The authors examined 22 state and local education agency guidelines available online to find commonalities related to the determination of a student's need for PT.

Results and Conclusions:
Seven commonalities found: educational benefit, team decision, need for PT expertise, establishment of Individualized Education Program (IEP) goal before determining need for PT, distinction between medical and educational PT, the student's disability adversely affects education, and the student's potential for improvement. These commonalities are discussed in relation to current PT and special education literature. This article suggests applying these commonalities as procedural requirements and questions for discussion during an IEP team meeting.
Trends, Frequency, and Nature of Surgeon-Reported Conflicts of Interest in Plastic Surgery
Authors: Lopez Joseph , Musavi Leila , Quan Amy , Calotta Nicholas , Juan Ilona , Park Angela , Tufaro Anthony P. , May James W. , Dorafshar Amir H. 
Published: September 2017

Background:
The purpose of this study was to identify types and trends in industry sponsorship of plastic surgery research since the establishment of conflict-of-interest reporting policies in plastic surgery.

Methods:
The authors analyzed the frequency and types of self-reported conflicts of interest in the plastic surgery literature since the adoption of reporting policies in 2007. All original articles that met the authors’ inclusion criteria and were published in the following three journals from 2008 to 2013 were included: Annals of Plastic Surgery, Plastic and Reconstructive Surgery, and Journal of Plastic, Reconstructive & Aesthetic Surgery. A multivariate regression analysis was performed to determine what study-specific variables were associated with conflict-of-interest disclosures.

Results:
A total of 3722 articles were analyzed. The incidence of conflicts of interest increased from 14 percent in 2008 to 24 percent in 2009. However, thereafter, the incidence of conflicts of interest decreased steadily from 21 percent in 2010 to 9 percent in 2013. Furthermore, the authors’ analysis revealed that from 2008 to 2013, industry decreased direct research support but steadily increased the rate of consultantships (p < 0.001). A multivariate regression analysis revealed that, after adjusting for potential confounders, self-reported conflicts of interest have decreased since 2008 (p = 0.03) and the prevalence of conflicts of interest differs by plastic surgery subspecialty (p < 0.0001), country of origin (p < 0.0001), and journal of publication (p = 0.05).

Conclusions:
If self-reporting of conflicts of interest is assumed to be accurate, the number of surgeon-reported conflicts of interest in plastic surgery declined overall. Although the absolute number of consultantships did not change, the rate of consultantships rather than direct research support increased over this period.
The Ethics of Sharing Plastic Surgery Videos on Social Media: Systematic Literature Review, Ethical Analysis, and Proposed Guidelines
Authors: Dorfman Robert G. , Vaca Elbert E. , Fine Neil A. , Schierle Clark F. 
Published: September 2017

Summary:
Recent videos shared by plastic surgeons on social media applications such as Snapchat, Instagram, and YouTube, among others, have blurred the line between entertainment and patient care. This has left many in the plastic surgery community calling for the development of more structured oversight and guidance regarding video sharing on social media. To date, no official guidelines exist for plastic surgeons to follow. Little is known about the ethical implications of social media use by plastic surgeons, especially with regard to video sharing. A systematic review of the literature on social media use in plastic surgery was performed on October 31, 2016, with an emphasis on ethics and professionalism. An ethical analysis was conducted using the four principles of medical ethics. The initial search yielded 87 articles. Thirty-four articles were included for analyses that were found to be relevant to the use of social media in plastic surgery. No peer-reviewed articles were found that mentioned Snapchat or addressed the ethical implications of sharing live videos of plastic surgery on social media. Using the four principles of medical ethics, it was determined that significant ethical concerns exist with broadcasting these videos. This analysis fills an important gap in the plastic surgery literature by addressing the ethical issues concerning live surgery broadcasts on social media. Plastic surgeons may use the guidelines proposed here to avoid potential pitfalls.
“Internet of Things” Real-Time Free Flap Monitoring
Authors: Kim Sang Hun , Shin Ho Seong , Lee Sang Hwan 
Published: September 2017

Background:
Free flaps are a common treatment option for head and neck reconstruction in plastic reconstructive surgery, and monitoring of the free flap is the most important factor for flap survival. In this study, the authors performed real-time free flap monitoring based on an implanted Doppler system and “internet of things” (IoT)/wireless Wi-Fi, which is a convenient, accurate, and efficient approach for surgeons to monitor a free flap.

Methods:
Implanted Doppler signals were checked continuously until the patient was discharged by the surgeon and residents using their own cellular phone or personal computer. If the surgeon decided that a revision procedure or exploration was required, the authors checked the consumed time (positive signal-to-operating room time) from the first notification when the flap's status was questioned to the determination for revision surgery according to a chart review. To compare the efficacy of real-time monitoring, the authors paired the same number of free flaps performed by the same surgeon and monitored the flaps using conventional methods such as a physical examination.

Results:
The total survival rate was greater in the real-time monitoring group (94.7% versus 89.5%). The average time for the real-time monitoring group was shorter than that for the conventional group (65 minutes versus 86 minutes).

Conclusions:
Based on this study, real-time free flap monitoring using IoT technology is a method that surgeon and reconstruction team can monitor simultaneously at any time in any situation.
Melanotic Neuroectodermal Tumor of Infancy in the Maxilla
Authors: Ünsal Haluk Yener , Yalçin Mustafa 
Published: September 2017

Abstract
Melanotic neuroectodermal tumor of infancy is uncommon and has rapid expansile growth. Melanotic neuroectodermal tumor of infancy is a very rare and benign but locally aggressive neoplasm that originates from neural crest and is composed of relatively primitive pigment-producing cells. The lesion commonly affects the maxilla of infants during the first year of life. Common treatment methods include surgical excision and resection of the tumor. The aim of this article is to present the diagnosis and treatment of a patient with melanotic neuroectodermal tumor that occurred in the anterior maxilla of a 6-month-old male baby.
A Novel Reverse Periauricular Flap Reconstruction Method That Uses Additional Anastomosis to Avoid Venous Congestion for Periorbital Defects
Authors: Xiao Hui , Wang Haiping 
Published: September 2017

Abstract
The aim of this study was to introduce and evaluate a method to prevent venous congestion in periauricular flap pedicled on the frontal branch of the superficial temporal artery (STA). Flaps based on the STA are therefore extremely versatile in reconstruction of the face and scalp. The literature on reconstructive possibilities provided by temporal flaps describes venous congestion, but there are currently no methods for preventing this problem. In this brief report, we describe a method to anastomose the parietal branch of superficial temporal vein and the middle temporal vein to ensure venous flow when a concomitant vein of the frontal branch of the STA is unavailable. The flap survived without venous congestion and donor sites healed with satisfactory outcomes. Color and texture match of the flap were excellent and morbidity at the donor site was usually minimal.
Level of Evidence: IV