bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Real Earnings Smoothing Harmful? Evidence from Firm‐Specific Stock Price Crash Risk
Authors: Khurana Inder K. , Pereira Raynolde , Zhang Eliza (Xia) 
Published: September 2017

AbstractThis study examines whether and when real earnings smoothing influences firm‐specific stock price crash risk. Using a sample of U.S. public firms for the years 1993 through 2014, we find real earnings smoothing to be positively associated with firm‐specific stock price crash risk. This finding is consistent with the view that real earnings smoothing helps managers withhold bad news, keep poor‐performing projects, conceal resource diversion, and engage in ineffective risk management, which increases crash risk. Further, we find a stronger relation between crash risk and real earnings smoothing when firm uncertainty is higher, product market competition is lower, and balance sheet constraint is higher. Overall, our study suggests that real earnings smoothing destroys shareholder value in that it increases stock price crash risk.
Disloyal Brokers and Weak Parties
Authors: Novaes Lucas M. 
Published: September 2017

AbstractThis article shows that the disloyalty of political brokers causes party fragility. Lacking distinctive brands, organization, and activists to mobilize individuals, parties “hire” local notables to broker votes among a local, nonpartisan constituency. However, brokers may be unreliable agents, regularly changing political allegiances in search of better returns for their brokerage among the module of voters they control. This free agency from brokers hinders durable party–voter linkages and results in electorally vulnerable parties. Measuring how brokers influence parties is empirically complex, but taking advantage of the fact that in Brazil these agents are also local candidates, this article demonstrates the negative electoral consequences of brokers' free agency on party performance. Natural experiments and an unexpected, temporary institutional reform that discouraged disloyalty for brokers demonstrate this relationship.
Association of breast milk fatty acids with allergic disease outcomes—A systematic review
Authors: Waidyatillake N. T. , Dharmage S. C. , Allen K. J. , Lodge C. J. , Simpson J. A. , Bowatte G. , Abramson M. J. , Lowe A. J. 
Published: September 2017

AbstractIntroductionDietary polyunsaturated fatty acids (PUFAs) have immunoregulatory properties. Breast milk is rich in PUFA, and it has been hypothesized that these PUFAs may be important in the aetiology of allergic diseases. Despite a growing body of evidence, the associations between breast milk PUFA and allergic disease have not previously been systematically reviewed.MethodsThe search was performed in PubMed and EMBASE databases using breastfeeding, fatty acid and allergic disease terms. Two authors were involved in selecting papers for review according to the inclusion criteria and extracting information on study characteristics and measures of association. Only studies that reported numeric associations between concentration of breast milk fatty acids and allergic disease outcomes were included.ResultsA total of 18 papers met the inclusion criteria, reporting results from 15 study populations. The majority were cohort studies (n=11), with data from only two case‐control and two cross‐sectional studies. Sample size varied between 30 and 352 participants, and follow‐up time of the cohorts varied between 3 months and 14 years. Nine studies reported on eczema, seven reported on sensitization, and only five reported on asthma/wheeze. There was heterogeneity among studies in terms of presenting the association between PUFA and allergy; therefore, estimates could not be pooled. Only a few studies observed associations between n‐3 and n‐6 PUFAs and allergic disease, and the magnitude of this effect varied greatly.ConclusionsThere is insufficient evidence to suggest that colostrum or breast milk polyunsaturated fatty acids influence the risk of childhood allergic diseases.
Review article: the human intestinal virome in health and disease
Authors: Carding S. R. , Davis N. , Hoyles L. 
Published: September 2017

SummaryBackgroundThe human virome consists of animal‐cell viruses causing transient infections, bacteriophage (phage) predators of bacteria and archaea, endogenous retroviruses and viruses causing persistent and latent infections. High‐throughput, inexpensive, sensitive sequencing methods and metagenomics now make it possible to study the contribution dsDNA, ssDNA and RNA virus‐like particles make to the human virome, and in particular the intestinal virome.AimTo review and evaluate the pioneering studies that have attempted to characterise the human virome and generated an increased interest in understanding how the intestinal virome might contribute to maintaining health, and the pathogenesis of chronic diseases.MethodsRelevant virome‐related articles were selected for review following extensive language‐ and date‐unrestricted, electronic searches of the literature.ResultsThe human intestinal virome is personalised and stable, and dominated by phages. It develops soon after birth in parallel with prokaryotic communities of the microbiota, becoming established during the first few years of life. By infecting specific populations of bacteria, phages can alter microbiota structure by killing host cells or altering their phenotype, enabling phages to contribute to maintaining intestinal homeostasis or microbial imbalance (dysbiosis), and the development of chronic infectious and autoimmune diseases including HIV infection and Crohn's disease, respectively.ConclusionsOur understanding of the intestinal virome is fragmented and requires standardised methods for virus isolation and sequencing to provide a more complete picture of the virome, which is key to explaining the basis of virome‐disease associations, and how enteric viruses can contribute to disease aetiologies and be rationalised as targets for interventions.
Systematic review with meta‐analysis: the association between hepatitis E seroprevalence and haemodialysis
Authors: Haffar S. , Bazerbachi F. , Leise M. D. , Dillon J. J. , Albright R. C. , Murad M. H. , Kamath P. S. , Watt K. D. 
Published: September 2017

SummaryBackgroundHepatitis E virus (HEV) infection appears to be more common than previously thought. HEV seroprevalence in patients on maintenance haemodialysis (HD) is unclear with a range from 0% to 44%. In addition, risk factors of transmission of HEV in patients on haemodialysis are unknown.AimTo perform a systematic review and meta‐analysis of HEV seroprevalence in HD patients compared with controls.MethodsA systematic search of several databases identified all observational studies with comparative arms. Two reviewers extracted data and assessed the methodological quality. A random‐effects model was used for pooled odds ratio (OR) and 95% confidence interval (CI) of positive anti‐HEV IgG in both groups. Heterogeneity and publication bias were assessed with appropriate tests.ResultsWe identified 31 studies from 17 countries between 1994 and 2016. Sixteen studies were judged to have adequate quality and 15 to have moderate limitations. HEV infection was more prevalent in patients on haemodialysis compared with controls (OR 2.47, 95% CI 1.79‐3.40, I2 = 75.2%, P < .01). We conducted several subgroup analyses without difference in results. Egger regression test did not suggest publication bias (P = .83). Specific risk factors of HEV transmission in patients on haemodialysis were not clearly identified.ConclusionsHepatitis E virus infection is more prevalent in patients on haemodialysis compared with non‐haemodialysis control groups. Further studies are needed to determine risk factors of acquisition, impact on health, and risk for chronic HEV especially among those patients going to receive organ transplantation.
Functional morphology and neuronal innervation of the prothoracic defence gland in Timema
Authors: Stolz Konrad 
Published: September 2017

AbstractTimema is the most basal genus of Phasmatodea and the sister group to the remaining stick and leaf‐insects (Euphasmatodea). An autapomorphy of all phasmids is the paired prothoracic exocrine defence glands. In this study, the anatomy and innervation of the defence glands in Timema petita and Timema chumash are described and compared with the data on Euphasmatodea. In all phasmids, the glands consist of a cuticular epithelium, a secretory epithelium and muscular fibres that compress the lumen. In Timematodea, the muscular part of the gland is less developed than in Euphasmatodea and the ejection of the defence secretion depends on the dorsal longitudinal neck muscles. On the neuroanatomical level, Timema petita and Timema chumash lack neurons that are involved in the independent contraction of the gland in euphasmids. In both studied species of Timema, neck muscles play an active role in the gland function which is not observed in any other phasmid. Considering the basal position of this genus, this supports the hypothesis that in euphasmids, the muscular part of the gland evolved from the dorsal longitudinal neck muscles. Additionally, the same nerves that innervate the dorsal longitudinal neck muscles in all Polyneoptera also innervate the defence glands in phasmids.
Examining the win‐win proposition of shared value across contexts: Implications for future application
Authors: Voltan Annika , Hervieux Chantal , Mills Albert 
Published: September 2017

AbstractThis article examines the concept of creating shared value (CSV) as articulated by Michael Porter and Mark Kramer, in non‐Western and Western contexts. We define non‐Western contexts as those in so‐called “developing” countries and emerging economies, whereas Western ones pertain to dominant thinking in “developed” regions. We frame our research in postcolonial theory and offer an overview of existing critiques of CSV. We conduct a critical discourse analysis of 66 articles to identify how CSV is being cited by authors, and potential underlying power dynamics that affect its relevance for non‐Western contexts. Our review exposes increasingly critical views about the paradoxical positioning of CSV as an instrumental concept that can offer “win‐win” solutions, particularly from those working in non‐Western settings. Western perspectives generally tend to be more supportive of its instrumental nature, but also recognize the increasing complexity of the business‐society nexus and stakeholder engagement. We argue that the CSV framework requires further development to maintain credibility and applicability, especially in non‐Western domains.
Ovarian cancer stem cells promote tumour immune privilege and invasion via CCL5 and regulatory T cells
Authors: You Y , Li Y , Li M , Lei M , Wu M , Qu Y , Yuan Y , Chen T , Jiang H 
Published: September 2017

Summary
Emerging evidence indicates a link between the increased proportion of regulatory T cells (Tregs) and reduced survival in patients who have been diagnosed with cancer. Cancer stem cells (CSCs) have been indicated to play a vital role in tumour initiation, drug resistance and recurrence. However, the relationship between Tregs and CSCs remains largely unknown. Here, we sorted out ovarian cancer stem-like side population (SP) cells and CD133+ cells to investigate the influence of ovarian CSCs on Tregs. Among the various immune-related molecules that we assessed, C-C motif chemokine ligand 5 (CCL5) was the most elevated in ovarian CSCs relative to that in the non-CSCs. The expression of its receptor, C-C motif chemokine receptor 5 (CCR5), was also increased on the surface of Tregs in ovarian cancer patients. This receptor-ligand expression profile indicated that ovarian CSCs recruit Tregs via CCL5–CCR5 interactions. We further assessed the expression of interleukin (IL)-10 in Tregs cultured with different cancer cells. Tregs cultured in conditioned medium (CM) from ovarian CD133+ cells expressed a higher level of IL-10 than Tregs cultured in CM from CD133– cells, indicating that Tregs exert pronounced immune-inhibitory functions in CSC-rich environments. Furthermore, co-culture with ovarian cancer cell lines induced the expression of matrix metalloproteinase-9 (MMP9) in Tregs which, in turn, enhanced the degradation of the extracellular matrix and enabled the invasion of tumour cells, thereby facilitating tumour metastasis. For the first time, to our knowledge, our findings describe the relationship between ovarian CSCs and Tregs, and demonstrated that these two cell populations co-operate to promote tumour immune tolerance and enhance tumour progression.
Cytological diagnostic clues in poorly differentiated squamous cell carcinomas of the breast: Streaming arrangement, necrotic background, nucleolar enlargement and cannibalism of cancer cells
Authors: Kinoshita M. , Matsuda Y. , Arai T. , Soejima Y. , Sawabe M. , Honma N. 
Published: September 2017

ObjectiveSquamous cell carcinoma (SCC) is a rare histological type of breast cancer. The cytological diagnosis of non‐keratinising, poorly differentiated SCC is often difficult, and distinguishing it from invasive ductal carcinoma or apocrine carcinoma (AC) is especially challenging. We aimed to define the diagnostic cytological features of poorly differentiated SCC of the breast.MethodsWe studied the cytological findings of poorly differentiated SCC (n=10) and compared them to those of IDC (n=15) and AC (n=14). The following six cytological features were evaluated: streaming arrangement, nucleolar enlargement, dense nuclei, cannibalism, atypical keratinocytes and necrotic background.ResultsSCC exhibited significantly higher frequencies of streaming arrangement (70% vs 6.7%, P=.002), nucleolar enlargement (80% vs 27%, P=.02), and necrotic background (80% vs 36%, P=.002) than invasive ductal carcinoma. The detection of two or three of these features yielded a higher sensitivity (80%) and specificity (93%) for the diagnosis of SCC. Streaming arrangement (70% vs 0%, P<.001), cannibalism (60% vs 0%, P=.002), and a necrotic background (80% vs 36%, P=.047) were all significantly more frequent in SCC than in AC. When distinguishing SCC from AC, the presence of two or three of these features yielded a high sensitivity (80%) and specificity (100%).ConclusionsCytological features such as a streaming arrangement, a necrotic background, nucleolar enlargement and cannibalism are useful indicators for the diagnosis of SCC of the breast. As such, greater attention should be paid to these morphological features in daily clinical practice.
Cannabis use among two national samples of Aboriginal and Torres Strait Islander tobacco smokers
Authors: Thomas David P. , Davey Maureen E. , Panaretto Kathryn S. , van der Sterren Anke E. 
Published: September 2017

AbstractIntroduction and AimsThere is a concern that cannabis use is an important barrier to reducing Aboriginal and Torres Strait Islander smoking. We investigate the associations of cannabis use and tobacco smoking and quitting in two large national samples.Design and MethodsThe 2012–2013 National Aboriginal and Torres Strait Islander Health Survey was a national stratified random household survey conducted between April 2012 and February 2013, and included 2580 adult Aboriginal and Torres Strait Islander smokers. The Talking About The Smokes Project interviewed a national quota sample of 1301 Aboriginal and Torres Strait Islander adult smokers between August 2013 and August 2014. Both surveys asked about tobacco smoking and quitting, cannabis use and socio‐demographic factors.ResultsBoth surveys estimated that cannabis use is common among Aboriginal and Torres Strait Islander smokers (National Aboriginal and Torres Strait Islander Health Survey: 32%, Talking About The Smokes: 24%). Both surveys found a higher prevalence of cannabis use among smokers who were male, younger, unemployed or who more frequently consumed five or more alcoholic drinks in a day. However, the two surveys provided inconsistent evidence about whether cannabis use is associated with not quitting smoking tobacco.Discussion and ConclusionsWe did not find consistent evidence in this setting that cannabis use is an obstacle to quitting tobacco smoking. Nevertheless, we would still recommend that clinicians counselling Aboriginal and Torres Strait Islander tobacco smokers about quitting talk about cannabis use because its use is common and almost all mix it with tobacco.
The Contemporary Constructive Task
Authors: Helmer Christine 
Published: September 2017

AbstractLutheran theology is noted for its excellent contributions to historical theology. Contemporary times, however, require that Lutheran theologians become attuned to the urgent demands of the present and take up the discipline of constructive theology to address these demands. Taking the lead from contemporary feminist Lutheran theologians, constructive approaches utilizing Lutheran theological resources must articulate vigorous critique of a corrosive neo‐liberal culture by articulating divine judgment on human greed as well as witnessing to divine grace that always favors truthful living.
Baptism in a Secular Age
Authors: Graff‐Kallevåg Kristin 
Published: September 2017

AbstractIn the Western world, the cultural conditions for interpreting and practicing baptism have changed radically in recent decades. An increasing level of religious plurality is one cultural trend that the theology of baptism must take seriously. One option for responding to this challenge is to interpret baptism as a rite of drastic communal transition whereby one enters into the church and leaves the world—with all its plurality—behind. Another option is to view baptism as a rite that, by bringing us into the church's fellowship with God in Christ, draws us into communion with all living creatures and calls upon us to engage in openness toward others.
Christian Participation and Creative Resistance: Reflecting on Luther's Two‐fold Governance in Muslim‐Majority Malaysia
Authors: Kit Sivin 
Published: September 2017

AbstractHow can Luther's contribution in theology and lessons arising from the Reformation have any relevance for Christians in Muslim‐majority Malaysia? In this article, I propose that a reflection on Luther's understanding of the so‐called “doctrine of two kingdoms”—better understood as God's two‐fold governance—offers a critical contribution that not only is relevant for the Malaysian Christian community, but also may have intercultural and interreligious implications for dialogue and engagement with the Muslim majority for interreligious solidarity and the common good.
Reception of Analogy of Being in Contemporary Eastern Orthodox Theology
Authors: Davydov Oleg 
Published: September 2017

AbstractThis article examines the relationship between the analogy of being (which is a fundamental principle of Catholic theology and metaphysics) and the most significant contemporary Eastern Orthodox theologians. This question of analogy touches upon the fundamental theological problem of the conceptualization of the relationship between God and creation. Even though there is no analogy in Eastern Orthodox theology, it has two polar positions regarding Western analogy of being—pro and con.
Fine‐scale acoustic telemetry reveals unexpected lake trout,Salvelinus namaycush, spawning habitats in northern Lake Huron, North America
Authors: Binder Thomas R. , Farha Steven A. , Thompson Henry T. , Holbrook Christopher M. , Bergstedt Roger A. , Riley Stephen C. , Bronte Charles R. , He Ji , Krueger Charles C. 
Published: September 2017

AbstractPrevious studies of lake trout,Salvelinus namaycush, spawning habitat in the Laurentian Great Lakes have used time‐ and labour‐intensive survey methods and have focused on areas with historic observations of spawning aggregations and on habitats prejudged by researchers to be suitable for spawning. As an alternative, we used fine‐scale acoustic telemetry to locate, describe and compare lake trout spawning habitats. Adult lake trout were implanted with acoustic transmitters and tracked during five consecutive spawning seasons in a 19–27 km2region of the Drummond Island Refuge, Lake Huron, using theVEMCOPositioning System. Acoustic telemetry revealed discrete areas of aggregation on at least five reefs in the study area, subsequently confirmed by divers to contain deposited eggs. Notably, several identified spawning sites would likely not have been discovered using traditional methods because either they were too small and obscure to stand out on a bathymetric map or because they did not conform to the conceptual model of spawning habitat held by many biologists. Our most unique observation was egg deposition in gravel and rubble substrates located at the base of and beneath overhanging edges of large boulders. Spawning sites typically comprised <10% of the reef area and were used consistently over the 5‐year study. Evaluation of habitat selection from the perspective of fish behaviour through use of acoustic transmitters offers potential to expand current conceptual models of critical spawning habitat.
Interactions among symbionts operate across scales to influence parasite epidemics
Authors: Halliday Fletcher W. , Umbanhowar James , Mitchell Charles E. 
Published: September 2017

AbstractParasite epidemics may be influenced by interactions among symbionts, which can depend on past events at multiple spatial scales. Within host individuals, interactions can depend on the sequence in which symbionts infect a host, generating priority effects. Across host individuals, interactions can depend on parasite phenology. To test the roles of parasite interactions and phenology in epidemics, we embedded multiple cohorts of sentinel plants, grown from seeds with and without a vertically transmitted symbiont, into a wild host population, and tracked foliar infections caused by three common fungal parasites. Within hosts, parasite growth was influenced by coinfections, but coinfections were often prevented by priority effects among symbionts. Across hosts, parasite phenology altered host susceptibility to secondary infections, symbiont interactions and ultimately the magnitude of parasite epidemics. Together, these results indicate that parasite phenology can influence parasite epidemics by altering the sequence of infection and interactions among symbionts within host individuals.