bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer
Authors: Bar-Peled Liron , Kemper Esther , Cravatt Benjamin 
Published: December 2017

Abstract
The b-ZIP transcription factor NRF2 is a master regulator of the cellular antioxidant response and frequently activated in Non-Small Cell Lung Cancers (NSCLCs). While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activation rewires metabolic and signaling networks in cancer cells that may create special vulnerabilities for therapeutic intervention. Here, we use chemical proteomics to map ligandable proteins in NRF2-activated NSCLC cells, leading to the discovery of metabolic and transcriptional pathways that are strictly regulated by NRF2. Principal among these was the orphan nuclear receptor NR0B1, which we show nucleates a multimeric protein complex required for the transcriptional output and anchorage-independent growth of NRF2-driven cancers. We further identify small-molecules that target a conserved cysteine within NR0B1's protein interaction domain and show that these chemical probes disrupt NR0B1 complexes and NRF2-dependent cancer cell growth. Our findings thus designate NR0B1 as a druggable, transcriptional co-dependency target for NRF2-activated lung cancers.
Citation Format: Liron Bar-Peled, Esther Kemper, Benjamin Cravatt. A druggable transcriptional vulnerability in NRF2-dependent lung cancer [abstract]. In: Proceedings of the AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; Jan 4-7, 2017; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2017;16(10 Suppl):Abstract nr PR16.
DNA Methyltransferase 1–Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point
Authors: Heuslein Joshua L. , Gorick Catherine M. , Song Ji , Price Richard J. 
Published: December 2017

Background

Arteriogenesis is initiated by increased shear stress and is thought to continue until shear stress is returned to its original “set point.” However, the molecular mechanism(s) through which shear stress set point is established by endothelial cells (
EC
s) are largely unstudied. Here, we tested the hypothesis that
DNA
methyltransferase 1 (
DNMT
1)–dependent
EC DNA
methylation affects arteriogenic capacity via adjustments to shear stress set point.

Methods and Results

In femoral artery ligation–operated C57
BL
/6 mice, collateral artery segments exposed to increased shear stress without a change in flow direction (ie, nonreversed flow) exhibited global
DNA
hypermethylation (increased 5‐methylcytosine staining intensity) and constrained arteriogenesis (30% less diameter growth) when compared with segments exposed to both an increase in shear stress and reversed‐flow direction. In vitro,
EC
s exposed to a flow waveform biomimetic of nonreversed collateral segments in vivo exhibited a 40% increase in
DNMT
1 expression, genome‐wide hypermethylation of gene promoters, and a
DNMT
1‐dependent 60% reduction in proarteriogenic monocyte adhesion compared with
EC
s exposed to a biomimetic reversed‐flow waveform. These results led us to test whether
DNMT
1 regulates arteriogenic capacity in vivo. In femoral artery ligation–operated mice,
DNMT
1 inhibition rescued arteriogenic capacity and returned shear stress back to its original set point in nonreversed collateral segments.

Conclusions

Increased shear stress without a change in flow direction initiates arteriogenic growth; however, it also elicits
DNMT
1‐dependent
EC DNA
hypermethylation. In turn, this diminishes mechanosensing, augments shear stress set point, and constrains the ultimate arteriogenic capacity of the vessel. This epigenetic effect could impact both endogenous collateralization and treatment of arterial occlusive diseases.
The Prevalence of Iron Deficiency Anemia and its Associated Risk Factors Among a Sample of Female University Students in Tabuk, Saudi Arabia
Authors: Alzaheb Riyadh A , Al-Amer Osama 
Published: December 2017

Background: Prior data on iron deficiency anemia’s (IDA) prevalence and associated risk factors among female university students are scarce in the Saudi Arabian context. This study therefore recruited a sample of female students at the University of Tabuk, Saudi Arabia, to investigate IDA prevalence and risk factors and fill the identified research gap. Methods: A cross-sectional study of 200 apparently healthy female students aged between 19 and 25 years was performed between February and June 2016. Data on the participants’ sociodemographics, diet, health, anthropometry, and hematological and biochemical iron status indices were gathered. A logistic regression analysis then revealed the IDA risk factors. Results: The IDA prevalence was 12.5%. The factors associated via logistic regression with an elevated anemia risk were inadequate iron and vitamin C intakes, infrequent (≤2 times per week) consumption of red meat, frequent (≥2 times per week) tea consumption, and a past personal history of IDA. Conclusions: The findings suggest that focused education and awareness strategies are needed to improve nutritional habits by encouraging the consumption of rich dietary iron sources and by raising awareness of the food and drinks which facilitate or hinder the bioavailability of iron.
A service evaluation of outcomes in two in-patient recovery units
Authors: Macpherson Rob , Calciu Claudia , Foy Chris , Humby Kim , Lozynskyj Dave , Garton Charles , Steer Hannah , Elliott Helen 
Published: December 2017

Aims and methodTo evaluate outcomes for patients during their admission or in the first year of treatment in two in-patient recovery units. Changes in health and social functioning, service use and need (rated by patients and staff) were evaluated.ResultsIn 43 patients treated, there was a large (30%) increase in patients discharged to their own tenancies, rather than supported accommodation. There was minimal change in Health of the Nation Outcome Scales (HoNOS) scores in the course of the admission but staff- and patient-rated unmet needs reduced and met needs increased. Needs changed mainly in domains relating to social functioning. Reductions in risk to self and others were rated by staff but not patients. There were no cases of patients being readmitted to acute hospital during the study period.Clinical implicationsAlthough these results offer some support to the treatment approach described in these in-patient recovery units, further research in larger samples is needed to identify how these services can best be deployed to help individuals with severe mental illness and complex needs.
New models of care: a liaison psychiatry service for medically unexplained symptoms and frequent attenders in primary care
Authors: Bestall Janine , Siddiqi Najma , Heywood-Everett Suzanne , Freeman Charlotte , Carder Paul , James Mick , Kennedy Brendan , Moulson Angela , House Allan 
Published: December 2017

Aims and methodThis paper describes the process of setting up and the early results from a new liaison psychiatry service in primary care for people identified as frequent general practice attenders with long-term conditions or medically unexplained symptoms. Using a rapid evidence synthesis, we identified existing service models, mechanisms to identify and refer patients, and outcomes for the service. Considering this evidence, with local contingencies we defined options and resources. We agreed a model to set up a service in three diverse general practices. An evaluation explored the feasibility of the service and of collecting data for clinical, service and economic outcomes.ResultsHigh levels of patient and staff satisfaction, and reductions in the utilisation of primary and secondary healthcare, with associated cost savings are reported.Clinical implicationsA multidisciplinary liaison psychiatry service integrated in primary care is feasible and may be evaluated using routinely collected data.
Implementation of a novel primary care pathway for patients with severe and enduring mental illness
Authors: Röhricht Frank , Waddon Gopal Krishan , Binfield Paul , England Rhiannon , Fradgley Richard , Hertel Lise , James Paul , Littlejohns Judith , Maher David , Oppong Matthew 
Published: December 2017

Aims and methodNew collaborative care models with an emphasis on primary care are required for long-term management of patients with severe and enduring mental illness (SMI). We conducted a descriptive evaluation of clinical outcomes of the first 3 years of a novel enhanced primary care (EPC) service. Data from 2818 patients and staff survey results were analysed.Results2310 patients were discharged to EPC (508 not assessed as clinically suitable or patients/general practitioners declined the transfer); mean length of stay with secondary care service of the cohort was 9.8 years (range 0–24). 717 patients (31%) have been discharged to primary care only out of the EPC services and 233 patients (10%) have been transferred back to secondary care. Patient and staff satisfaction with the new EPC model was high. No severe untoward incidents were recorded.Clinical implicationsThe data suggest that EPC can be safely provided for a significant proportion of patients with SMI, who traditionally received long-term secondary care support. The novel EPC model can be utilised as a template for the provision of cost-effective, recovery-oriented and non-stigmatising care in the community.
Phylogenetic relationships in Seslerieae (Poaceae) including resurrection of Psilathera and Sesleriella, two monotypic genera endemic to the Alps
Authors: Kuzmanović Nevena , Lakušić Dmitar , Frajman Božo , Alegro Antun , Schönswetter Peter 
Published: December 2017

AbstractSesleria (Poaceae) is a species‐rich, taxonomically difficult genus due to high morpho‐anatomical variability and weak differentiation of many species. It is distributed throughout western Eurasia and North Africa with highest taxonomic diversity on the Balkan Peninsula. Of the more than 40 species only two are diploid, all others are tetra‐ to dodecaploid, and many species comprise several ploidy cytotypes. We sequenced the plastid trnL‐ndhF region and produced amplified fragment length polymorphisms (AFLPs) from a comprehensive, ploidy‐cytotyped sampling including 292 populations, and produced nuclear ribosomal internal transcribed spacer (ITS) sequences for a subsample. Our first aim was to determine the relationships among Sesleria and putatively closely related genera. Further, we explored whether diploid S. sphaerocephala and S. ovata should be treated as separate genera Sesleriella and Psilathera as proposed previously, or rather included in Sesleria, following most recent Floras. Finally, we tested previous hypotheses of infrageneric classifications. In the ITS phylogeny tetra‐ to dodecaploid Sesleria s.str. grouped with diploid S. ovata whereas diploid S. sphaerocephala was more distantly related. In contrast, in the plastid phylogeny Sesleria s.str. grouped with S. sphaerocephala, whereas S. ovata was sister to Echinaria. This suggests an allopolyploid origin of Sesleria s.str. with S. sphaerocephala acting as maternal and S. ovata as paternal species. The lack of monophyly of Sesleria s.l. thus supports the recognition of S. ovata and S. sphaerocephala as separate genera Psilathera and Sesleriella. Their segregation, which is also supported by morphology, increases the number of angiosperm genera endemic to the European Alps from three to five. In congruence with the plastid sequences, AFLPs resolved the traditionally recognized sections (sect. Argenteae, sect. Sesleria) as non‐overlapping clusters and identified S. vaginalis as a probably recently evolved intersectional hybrid. Within the two sections, several informal species groups could be recognized, which show limited congruence with those proposed in the most comprehensive taxonomic treatment of the genus. From an evolutionary point of view it is obvious that ancient as well as recent hybridization coupled with polyploidisation have played a crucial role in diversification within Sesleria.
Tecnologia Assistiva para uma Escola Inclusiva: Desafios e Perspectivas
Authors: Alencar Simone Dos Santos , França Aurenia Pereira de 
Published: December 2017

A abordagem apresentada neste artigo tem como temática a Tecnologia Assistiva para Escola Inclusiva, a qual seu maior desafio é ofertar à acessibilidade para as pessoas com deficiência, garantindo igualdade de condições com os demais. Objetivando analisar a contribuição da tecnologia assistiva na inclusão de crianças em ambiente escolar. Este estudo torna-se propício para as atividades das crianças, com algum tipo de deficiência. A metodologia utilizada para desenvolver o presente estudo é de ordem bibliográfica e qualitativa. Os teóricos que fundamentam essa pesquisa são: Miranda (2006), Galvão (2004), Kleiman (2007), entre outras fontes. Observou-se que é de grande relevância o processo de apropriação e uso da tecnologia assistiva. A fim de melhorar a qualidade de vida de todas as pessoas, para que sejam vistas de forma inclusiva diante da sociedade. Palavras-chave:
Effects of adapted physical activity applied on intellectual disability students toward level of emotional adjustment, self-managingand the socialization: Parent and teacher interactive research
Authors: Güvendi Burcu , İlhan Ekrem Levent 
Published: December 2017

The purpose of the research is to investigate the effects of adapted physical activity applied on intellectual disability students toward level of emotional adjustment, self-managing and the socialization. The study was designed as pretest-posttest experimental model. Intellectual disab 12 students from 5th and 6th grade who continue their education at the public school in Esenyurt district of İstanbul in 2015-2016 academic year spring semester. Adapted physical activity program was applied the students for 2 days 1 hour per week for 12 week. Hacettepe Emotional Adjustment Scale, Self-Managing and Socialization which of subheading AAMD Adaptive Behavior Scala were used to collect data. Pretest-posttest descriptive analysis was and Wilcoxon Test was used in dependent comparisons. The results showed that decline in students’ pretest-posttest mean scores of neurotic problems and behavior problems was seen according to mothers and the school counselor of the students. An increase was observed in pretest-posttest mean scores of self-managing and socialization on behalf of the posttest. According to data from mother and school counselor, significant differences were determined between pretest-posttest on behalf of the posttest in neurotic and behavior problems which of subheading Emotional Adjustment Scale, self-managing and socialization which of subheading AAMD Adaptive Behavior Scala. Adapted physical activity applied on intellectual disability students affected positively level of emotional adjustment; self-managing and the socialization were seen. Additionally students’ socialization scores increased and emotional adjustment problems decreased were observed.
The long non-coding RNA CRNDE promotes cervical cancer cell growth and metastasis
Authors: Meng Yuanyuan , Li Qi , Li Lianwei , Ma Rong 
Published: December 2017

AbstractThis study was intended to analyze effects of lncRNA CRNDE on cervical cancer cell growth and metastasis. Fifty pairs of cervical cancer tissues and corresponding adjacent tissues were collected. Expressions of long non-coding RNAs (lncRNAs) in tissue samples were detected by microarray analysis. Expression levels of CRNDE in cervical cancer cells and normal cells were detected by qRT-PCR. Cell-counting kit-8 (CCK-8) assay and clone formation assay were utilized to evaluate cell growth. Wound healing assay and Transwell assay were conducted to detect the migratory and invasive capability of cervical cancer cells. The expressions of CRNDE in cervical cancer tissues and cells were higher than those in normal tissues and cells. CCK-8 assay and clone formation assay showed that the knockdown of CRNDE could inhibit the cell proliferation of HeLa and C-33A cells. Wound healing assay indicated that the downregulation of CRNDE expression could suppress the cell migration. The result of a Transwell assay demonstrated that the number of invasion cells reduced in the CRNDE-si group in comparison with the Mock group. LncRNA CRNDE could promote the cell growth and stimulate the metastasis of cervical cancer cells.
Tragicomedy and Literary Decorum: Theoretical Foundations of the “Third Dramatic Genre” in the Origins of Spanish Theater
Authors: Mañero-Lozano David 
Published: December 2017

AbstractThis paper, which evaluates the theoretical underpinnings of tragicomedy, examines the ideas on literary decorum that formed the basis for the traditional definitions of the different dramatic genres. Within this context, an argument is made that the emergence of the ‘third genre’ was associated with changing views on the adaptation of theater to bring it into line with the concept of literary
Analysis of a regularized model for the isothermal two-component mixture with the diffuse interface
Authors: Balashov Vladislav , Zlotnik Alexander , Savenkov Evgeny 
Published: December 2017

AbstractA regularized system of equations describing a flow of isothermal two-component mixture with diffuse interface is studied. The equation of energy balance and its corollary, i.e., the law of non-increasing of the total energy are derived under general assumptions on the Helmholtz free energy of the mixture. Necessary and sufficient conditions for linearized stability of constant solutions are obtained (in particular case). A difference approximation of the problem is constructed in the two-dimensional periodic case on a nonuniform rectangular grid. The results of numerical experiments demonstrate a qualitative well-posedness of the problem and the applicability of the criterion of linearized stabilization in the original nonlinear formulation.
The method of hypersingular integral equations in the problem of electromagnetic wave diffraction by a dielectric body with a partial perfectly conducting coating
Authors: Setukha Alexey V. , Bezobrazova Elizaveta N. 
Published: December 2017

AbstractA problem of scattering of a monochromatic electromagnetic wave by a homogeneous dielectric body is considered. A part of the boundary of the body is a perfectly conducting thin surface. The problem is reduced to a system of the boundary integral equations containing integrals with strong singularity, the integrals are understood in terms of Hadamard final part. A numerical solution scheme is constructed on the base of approximate solution of these equations using the methods of piecewise-constant approximations and collocation. The constructed numerical scheme is tested on a model example.
The date of the Martyrdom of Simeon bar Sabba’e and the persecution of Christians in Persia under Shapur II
Authors: Kosiński Rafał 
Published: December 2017

Abstract:The article is a contribution to the more than one-hundred-year-long discussion on the date of death of Simeon bar Sabba’e, metropolitan bishop of Seleucia-Ctesiphon, and the beginning of the persecution of Christians in Persia during the reign of Shapur II. The author stresses the point that the main source on Simeon’s martyrdom is a hagiographical work and, as such, it should be interpreted strictly on the basis of the principles relevant to the genre. Taking some of the hypotheses formulated to date into consideration, the author holds the view that it is not possible to determine the precise date of Simeon’s death. It could only be assumed that it must have occurred somewhere between February 344 and July 345, most likely in late 344.
Algunas observaciones sobre la noción kantiana de simultaneidad.
Authors: Oroño Matías Hernán 
Published: December 2017

Se comparan los análisis sobre la simultaneidad que Kant efectúa en la “Tercera Analogía de la Experiencia” (KrV) y en la “Analítica de lo sublime” (KU) con el fin de comprender las diferencias entre ambos enfoques. Se intenta demostrar que la intuición de la simultaneidad tal como es desarrollada en el marco de lo sublime subyace a las unidades fundamentales de síntesis mencionadas en los “Axiomas de la intuición” (KrV). Asimismo, se señala que la intuición de la simultaneidad tal como es explicada en la “Analítica de lo sublime” (KU) no se identifica necesariamente con la noción de “magnitud absoluta”.
La respuesta merleaupontyana a la “inducción pesimista” como posible complemento de su polémica contra el escepticismo
Authors: Cormick Claudio Javier 
Published: December 2017

Intentaremos completar el análisis de la relación entre Merleau-Ponty y distintas posiciones escépticas -típicamente restringido a textos más “canónicos”- a partir de su conferencia sobre Le primat de la perception. El fenomenólogo argumenta allí contra la “inducción pesimista” según la cual podemos, a la luz de la refutación de las hipótesis científicas pasadas, prever que las actuales son también falsas: invirtiendo la conclusión de esta inducción, afirma que las transformaciones de nuestro conocimiento son un proceso autocorrectivo, tal que ninguna hipótesis es abandonada sino en la medida en que otra aparece como mejor. Esto nos hará problematizar la noción de refutación científica en Merleau-Ponty, quien ofrece como modelo del progreso epistémico la mutua sustitución (“espontánea”) de creencias perceptivas, que no involucra la consideración consciente de criterios racionales. Según señalaremos, este punto de partida no puede extrapolarse al caso de hipótesis sopesadas según sus respectivas virtudes.
La narrativa reflexiva como forma de evaluación programática (Reflective Narratives as a Type of Program Evaluation)
Authors: Martínez-Arbelaiz Asunción 
Published: December 2017

Mostrar la eficacia de un programa de enseñanza de lenguas ante las partes interesadas y a la vez señalar áreas o aspectos por mejorar son los objetivos de la evaluación de programas. En este artículo se describe el proceso de evaluación de tres programas de español como segunda lengua en situación de inmersión, en el que se difuminan los límites entre el aprendizaje dentro y fuera del aula. La investigación narrativa se presenta como opción metodológica que permite comprender la experiencia de los participantes, de forma completa y matizada. Abstract To show the efficiency of a given language program to interested stakeholders and to point to areas or aspects that require improvement are the two main objectives of any program evaluation. In this article, we describe the evaluation process of three Spanish as a second language programs in a study abroad context, where boundaries between learning inside and outside the classroom necessarily blur. Narrative inquiry is our methodological option because it allows us to understand the students experience in a holistic and nuanced manner.