bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent development of transcatheter closure of atrial septal defect and patent foramen ovale with occluders
Authors: Tang Baiyu , Su Feng , Sun Xiangke , Wu Qin , Xing Quansheng , Li Suming 
Published: December 2016

AbstractAtrial septal defect (ASD) and patent foramen ovale (PFO) are common clinical congenital heart defects. As an effective method for the treatment of ASD and PFO, transcatheter closure with occluders presents many advantages, including safety, ease of operation, minimal invasiveness, and reduced complications. This contribution reviews the various types of occluders currently used in clinical applications and under development, including non degradable occluders, partially degradable occluders, and totally degradable occluders. A number of case studies are described in detail. Comparison is made on the treatment outcomes using different occulders. Future development of transcatheter closure is discussed, in particular the use of totally degradable occluders. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 433–443, 2018.
Dietary Inflammatory Index, Bone Mineral Density, and Risk of Fracture in Postmenopausal Women: Results From the Women's Health Initiative
Authors: Orchard Tonya , Yildiz Vedat , Steck Susan E , Hébert James R , Ma Yunsheng , Cauley Jane A , Li Wenjun , Mossavar-Rahmani Yasmin , Johnson Karen C , Sattari Maryam , LeBoff Meryl , Wactawski-Wende Jean , Jackson Rebecca D 
Published: December 2016

ABSTRACT

Previous studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association of the dietary inflammatory index (DII), a measure of the inflammatory potential of diet, with risk of hip, lower-arm, and total fracture using longitudinal data from the Women's Health Initiative Observational Study and Clinical Trials. Secondarily, we evaluated changes in bone mineral density (BMD) and DII scores. DII scores were calculated from baseline food frequency questionnaires (FFQs) completed by 160,191 participants (mean age 63 years) without history of hip fracture at enrollment. Year 3 FFQs were used to calculate a DII change score. Fractures were reported at least annually; hip fractures were confirmed by medical records. Hazard ratios for fractures were computed using multivariable-adjusted Cox proportional hazard models, further stratified by age and race/ethnicity. Pairwise comparisons of changes in hip BMD, measured by dual-energy X-ray absorptiometry from baseline, year 3, and year 6 were analyzed by quartile (Q1 = least inflammatory diet) of baseline DII scores in a subgroup of women (n = 10,290). Mean DII score improved significantly over 3 years (p &lt; 0.01), but change was not associated with fracture risk. Baseline DII score was only associated with hip fracture risk in younger white women (HR Q4,1.48; 95% CI, 1.09 to 2.01; p = 0.01). There were no significant associations among white women older than 63 years or other races/ethnicities. Women with the least inflammatory DII scores had less loss of hip BMD (p = 0.01) by year 6, despite lower baseline hip BMD, versus women with the most inflammatory DII scores. In conclusion, a less inflammatory dietary pattern was associated with less BMD loss in postmenopausal women. A more inflammatory diet was associated with increased hip fracture risk only in white women younger than 63 years. © 2016 American Society for Bone and Mineral Research.
Diaphyseal Femur Fractures in Osteogenesis Imperfecta: Characteristics and Relationship With Bisphosphonate Treatment
Authors: Trejo Pamela , Fassier François , Glorieux Francis H , Rauch Frank 
Published: December 2016

ABSTRACT

Several recent case reports have suggested that bisphosphonate treatment in individuals with osteogenesis imperfecta (OI) is causally related to atypical femur fractures. However, it is not known whether atypical femur fractures are actually more frequent in patients who have received bisphosphonates. In the present study, we retrospectively analyzed 166 femur fractures in 119 children with a diagnosis of OI that had not undergone intramedullary rodding procedures. A total of 130 fractures in 90 patients occurred in femurs with preexisting deformities (age at fracture between 1 month and 19.9 years; 43 girls). Because deformities are a typical cause of fracture in OI, deformed femurs were excluded from the analysis of atypical fractures. However, it was noted that in deformed femurs a transverse fracture pattern (one of the criteria of atypical fractures) was associated with a moderate to severe OI phenotype and not related to bisphosphonate treatment. Of the 36 fractures that occurred in nondeformed femurs (30 individuals; age at fracture between 1 month and 17.4 years; 13 girls), 11 (in nine children) occurred during bisphosphonate treatment. Three of these fractures (27%) resembled atypical femur fractures. Among the 25 femur fractures (23 patients) that occurred in the absence of prior bisphosphonate treatment, 8 (22%) resembled atypical femur fractures. Logistic regression analysis showed that bisphosphonate treatment history was not associated with the occurrence of atypical fractures. In contrast, the presence of moderate to severe OI (defined as any OI type other than OI type I) was strongly associated with atypical femur fractures. Thus, we observed an atypical appearance in about a quarter of nondeformed femur fractures that occurred in children with OI. Such atypical femur fractures seemed to be related to the severity of OI rather than to bisphosphonate treatment history. © 2016 American Society for Bone and Mineral Research.
Prestructural cartilage assessment using MRI
Authors: Link Thomas M. , Neumann Jan , Li Xiaojuan 
Published: December 2016

Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy. Moreover, we highlighted important clinical applications. This review article focuses on the currently most relevant and clinically applicable technologies, such as T2 mapping, T2*, T1ρ, delayed gadolinium enhanced MRI of cartilage (dGEMRIC), sodium imaging and glycosaminoglycan chemical exchange saturation transfer (gagCEST). To date, most information is available for T2 and T1ρ mapping. dGEMRIC has also been used in multiple clinical studies, although it requires Gd contrast administration. Sodium imaging and gagCEST are promising technologies but are dependent on high field strength and sophisticated software and hardware.Level of Evidence: 5J. Magn. Reson. Imaging 2017;45:949–965
Clinically relevant hydrogel‐based on hyaluronic acid and platelet rich plasma as a carrier for mesenchymal stem cells: Rheological and biological characterization
Authors: Vadalà Gianluca , Russo Fabrizio , Musumeci Maria , D'Este Matteo , Cattani Caterina , Catanzaro Giuseppina , Tirindelli Maria Cristina , Lazzari Lorenza , Alini Mauro , Giordano Rosaria , Denaro Vincenzo 
Published: December 2016

ABSTRACTIntervertebral disc regeneration is quickly moving towards clinical applications. However, it is still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new injectable hydrogel composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed to generate a clinically relevant cell carrier for disc regeneration. PRP/HA/BTX blend was tested for rheological properties. Amplitude sweep, frequency sweep, and rotational measurements were performed and viscoelastic properties were evaluated. Human MSC encapsulated in PRP/HA/BTX hydrogel were cultured in both growing medium and medium with or without TGF‐β1 up to day 21. The amount of glycosaminoglycan was evaluated. Quantitative gene expression evaluation for collagen type II, aggrecan, and Sox 9 was also performed. Rheological tests showed that the hydrogel jellifies in 15 min 20°C and in 3 min at 37°C. Biological test showed that MSCs cultured in the hydrogel maintain high cell viability and proliferation. Human MSC within the hydrogel cultured with or without TGF‐β1 showed significantly higher GAG production compared to control medium. Moreover, MSCs in the hydrogel underwent differentiation to chondrocyte‐like cells with TGF‐β1, as shown by histology and gene expression analysis. This novel hydrogel improves viability and proliferation of MSCs supporting the differentiation process toward chondrocyte‐like cells. Rheology tests showed optimal gelation kinetics at room temperature for manipulation and faster gelation after transplantation (37°C). The clinical availability of all components of the hydrogel will allow a rapid translation of this regenerative approach into the clinical scenario. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2109–2116, 2017.
Porous UHMWPE Membranes and Composites Filled with Carbon Nanotubes: Permeability, Mechanical, and Electrical Properties
Authors: Otto Christian , Handge Ulrich A. , Georgopanos Prokopios , Aschenbrenner Ortrud , Kerwitz Juliane , Abetz Clarissa , Metze Anke‐Lisa , Abetz Volker 
Published: December 2016

Application of electric fields as a mechanism against membrane fouling is an emerging cleaning process for membranes. Sintering of ultrahigh molecular weight polyethylene powder particles decorated with multiwalled carbon nanotubes (MWCNT) is performed to produce electrically conductive porous filtration membranes. The contact of the molten particle surfaces leads to their fusion through neck formation during sintering. As the MWCNT only cover the surface of the powder particles, they form a conductive network with a high number of inter‐MWCNT contacts in pathways through the polymer matrix. Membranes with an electrical conductivity of 0.9 S m−1 at a MWCNT concentration of 5.0 wt% are prepared. Additionally, a comparison of sintered and compression molded samples shows that after the heating interval, crystallization during cooling strongly influences the formation of the MWCNT network. The study reveals that electrically conductive, porous polymer membranes for microfiltration applications can be prepared using a solvent‐free process.
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Zinc‐rich oysters as well as zinc‐yeast‐ and astaxanthin‐enriched food improved sleep efficiency and sleep onset in a randomized controlled trial of healthy individuals
Authors: Saito Hitomi , Cherasse Yoan , Suzuki Rina , Mitarai Makoto , Ueda Fumitaka , Urade Yoshihiro 
Published: December 2016

ScopeZinc is an essential mineral that plays an important role in the body. We previously reported that orally feeding zinc‐enriched yeast to mice induces nonrapid‐eye‐movement sleep. In addition, astaxanthin, an antioxidant abundant in seafood such as salmon and krill, is able to chelate minerals and may promote zinc absorption, which in return may also improve sleep. The purpose of our study was to examine the effect of zinc‐rich and astaxanthin‐containing food on sleep in humans.Methods and resultsWe conducted a randomized, double‐blinded, placebo‐controlled parallel group trial of 120 healthy subjects and recorded their night activity by actigraphy for 12 weeks. These subjects were divided into four groups: placebo, zinc‐rich food, zinc‐, and astaxanthin‐rich food, and placebo supplemented with zinc‐enriched yeast and astaxanthin oil. Compared with the placebo group, the zinc‐rich food group efficiently decreased the time necessary to fall asleep and improved sleep efficiency, whereas the group that ingested zinc‐enriched yeast and astaxanthin oil significantly improved the sleep onset latency.ConclusionActigraphic sleep monitoring demonstrated that eating zinc‐rich food improved sleep onset latency as well as improved the sleep efficiency in healthy individuals.
qNMR for profiling the production of fungal secondary metabolites
Authors: Brooks Wilson C. , Paguigan Noemi D. , Raja Huzefa A. , Moy Franklin J. , Cech Nadja B. , Pearce Cedric J. , Oberlies Nicholas H. 
Published: December 2016

Analysis of complex mixtures is a common challenge in natural products research. Quantitative nuclear magnetic resonance spectroscopy offers analysis of complex mixtures at early stages and with benefits that are orthogonal to more common methods of quantitation, including ultraviolet absorption spectroscopy and mass spectrometry. Several experiments were conducted to construct a methodology for use in analysis of extracts of fungal cultures. A broadly applicable method was sought for analysis of both pure and complex samples through use of an externally calibrated method. This method has the benefit of not contaminating valuable samples with the calibrant, and it passed scrutiny for line fitting and reproducibility. The method was implemented to measure the yield of griseofulvin and dechlorogriseofulvin from three fungal isolates. An isolate ofXylaria cubensis(coded MSX48662) was found to biosynthesize griseofulvin in the greatest yield, 149 ± 8 mg per fermentation, and was selected for further supply experiments. Copyright © 2016 John Wiley & Sons, Ltd.
Estimating and eliminating the excitation errors in bipolar gradient composite excitations caused by radiofrequency‐gradient delay: Example of bipolar spokes pulses in parallel transmission
Authors: Tse Desmond H.Y. , Wiggins Christopher J. , Poser Benedikt A. 
Published: December 2016

PurposeTo eliminate a slice‐position–dependent excitation error commonly observed in bipolar‐gradient composite excitations such as spokes pulses in parallel transmission.Theory and MethodsAn undesired timing delay between subpulses in the composite pulse and their bipolar slice‐selective gradient is hypothesized to cause the error. A mathematical model is presented here to relate this mismatch to an induced slice‐position–dependent phase difference between the subpulses. A new navigator method is proposed to measure the timing mismatch and eliminate the error. This is demonstrated at 7 Tesla with flip‐angle maps measured by a presaturation turbo‐flash sequence and in vivo images acquired by a simultaneous multislice/echo‐planar imaging (SMS‐EPI) sequence.ResultsError‐free flip‐angle maps were obtained in two ways: 1) by correcting the time delay directly and 2) by applying the corresponding slice‐position–dependent phase differences to the subpulses. This confirms the validity of the mathematical description. The radiofrequency (RF)‐gradient delay measured by the navigator method was of 6.3 μs, which agreed well with the estimate from flip‐angle maps at different delay times. By applying the timing correction, accurately excited EPI images were acquired with bipolar dual‐spokes SMS‐2 excitations.ConclusionAn effective correction is proposed to mitigate slice‐position–dependent errors in bipolar composite excitations caused by undesired RF‐gradient timing delays. Magn Reson Med 78:1883–1890, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
A culturally adapted survivorship programme for Asian early stage breast cancer patients in Singapore: A randomized, controlled trial
Authors: Chan Alexandre , Gan Yan Xiang , Oh Suan Kai , Ng Terence , Shwe Maung , Chan Raymond , Ng Raymond , Goh Brandon , Tan Yee Pin , Fan Gilbert 
Published: December 2016

AbstractBackgroundAs cancer mortality rates improve in Singapore, there is an increasing need to improve the transition to posttreatment survivorship care. This study aimed to evaluate the effectiveness of a psychoeducation group (PEG) intervention program compared with usual care to reduce distress for physical symptom and psychological aspects in Asian breast cancer survivors who have completed adjuvant chemotherapy.MethodsThis was a randomized, controlled trial comprising 72 Asian early stage breast cancer survivors who were randomized into the PEG (n = 34) or the control (n = 38) arm. The participants in the PEG arm underwent a weekly multidisciplinary PEG program delivered in a group format over 3 weeks coupled with cultural adaptation. Both arms were assessed at baseline and 2 months after intervention using the Rotterdam Symptom Checklist, Beck Anxiety Inventory, and EORTC QLQ‐C30. A satisfaction questionnaire was also conducted among those survivors who have participated in the PEG program. Effective sizes were calculated using Cohen d.ResultsThe mean age ± SD of all participants was 53.0 ± 8.9 years, with the majority being Chinese (84.7%) and Malay (6.9%), and clinical characteristics were well balanced in both arms. Compared to the control arm, the PEG arm showed a significantly greater reduction in physical symptom distress (d = 0.76, P = .01) and fatigue (d = 0.49, P = .04). The 82.4% of the participants in the intervention group responded to the satisfaction questionnaire, and the majority (92.9%) agreed that the overall duration of the PEG intervention program was appropriate.ConclusionsA culturally adapted PEG program was effective in reducing physical symptom distress in Asian breast cancer survivors. (ClinicalTrials.gov: NCT02600299)
Conformational stability of the epidermal growth factor (EGF) receptor as influenced by glycosylation, dimerization and EGF hormone binding
Authors: Taylor Eric S. , Pol‐Fachin Laercio , Lins Roberto D. , Lower Steven K. 
Published: December 2016

ABSTRACTThe epidermal growth factor receptor (EGFR) is an important transmembrane glycoprotein kinase involved the initiation or perpetuation of signal transduction cascades within cells. These processes occur after EGFR binds to a ligand [epidermal growth factor (EGF)], thus inducing its dimerization and tyrosine autophosphorylation. Previous publications have highlighted the importance of glycosylation and dimerization for promoting proper function of the receptor and conformation in membranes; however, the effects of these associations on the protein conformational stability have not yet been described. Molecular dynamics simulations were performed to characterize the conformational preferences of the monomeric and dimeric forms of the EGFR extracellular domain upon binding to EGF in the presence and absence of N‐glycan moieties. Structural stability analyses revealed that EGF provides the most conformational stability to EGFR, followed by glycosylation and dimerization, respectively. The findings also support that EGF–EGFR binding takes place through a large‐scale induced‐fitting mechanism. Proteins 2017; 85:561–570. © 2016 Wiley Periodicals, Inc.
Identification and detection of indoxacarb resistance mutations in the para sodium channel of the tomato leafminer, Tuta absoluta
Authors: Roditakis Emmanouil , Mavridis Konstantinos , Riga Maria , Vasakis Emmanouil , Morou Evangelia , Rison Jean Luc , Vontas John 
Published: December 2016

AbstractBACKGROUNDIndoxacarb is an important active ingredient extensively used for the control of Tuta absoluta, a major tomato pest, playing a particular role in insecticide resistance management schemes.RESULTSReduced susceptibility to indoxacarb was identified (1794‐fold resistance) through toxicological bioassays in a field population from Greece and evolved rapidly to resistance after short laboratory selection. Combined bioassays with synergists and biochemical analysis suggested only a partial involvement of detoxification enzymes in the resistant phenotype. To investigate the role of target‐site resistance, segment 6 of domain IV of the sodium channel in T. absoluta was cloned and the sequences compared between susceptible and indoxacarb‐resistant T. absoluta insects. The presence of the F1845Y and the V1848I indoxacarb resistance mutations was detected and was strongly associated with the phenotype. These amino acid substitutions correspond to recently characterised indoxacarb resistance mutations in diamondback moth (Plutella xylostella). Robust and accurate PCR‐RFLP assays were subsequently developed and successfully validated for detecting both indoxacarb resistance mutations in field T. absoluta populations.CONCLUSIONThe identification of indoxacarb resistance mutations and the development of diagnostic tools will allow early detection of indoxacarb resistance, facilitating implementation of appropriate resistance management strategies, thus delaying the spread of resistance. © 2016 Society of Chemical Industry
Meta-Analysis of Prevalence of Erectile Dysfunction in Mainland China: Evidence Based on Epidemiological Surveys
Authors: Wang Wenying , Fan Jingyuan , Huang Guifeng , Zhu Xi , Tian Ye , Tan Hua , Su Li 
Published: December 2016

Abstract

Introduction
The epidemiologic characteristics of erectile dysfunction (ED) in mainland China remain incompletely understood.

Aim
To evaluate the overall prevalence and determine the severity of ED in mainland China.

Methods
An extensive database search was performed of PubMed, Embase, the Chinese National Knowledge Infrastructure (CNKI) database, the WanFang database, the Chinese Biological Medical Literature (CBM) database, and the Chongqing VIP using the following terms: erectile dysfunction, prevalence, epidemiology, epidemiological, and China. Study quality was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Data were pooled for the random-effects model. Sensitivity analyses were conducted to assess potential bias.

Main Outcome Measures
All survey studies reporting on the prevalence of ED in mainland China were included. Data extraction was performed independently by two of the authors, and conflicts were resolved by another author.

Results
Of 2,155 retrieved articles, 25 were included in this meta-analysis with a total of 48,254 participants. The pooled prevalence of ED in men was 49.69% (95% CI = 39.29–60.10). The occurrence rates of ED in age groups younger than 30, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and at least 70 years were 20.86%, 25.30%, 40.48%, 60.12%, 79.10%, and 93.72%, respectively. The severity-specific prevalences of mild, moderate, and severe ED were 32.54%, 9.86%, and 13.97%, respectively. Moreover, the prevalences reported by different diagnostic methods were 14.19% for self-reports, 44.60% for the Chinese Index of Erectile Function, and 49.91% for the International Index of Erectile Function–5. The prevalence map based on a geographic information system showed an unequal geographic distribution.

Conclusion
ED is highly prevalent in mainland China, and its prevalence increases with age. More high-quality surveys on ED with larger samples throughout mainland China are needed to confirm these findings.