bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do runners who suffer injuries have higher vertical ground reaction forces than those who remain injury-free? A systematic review and meta-analysis
Authors: van der Worp Henk , Vrielink Jelte W , Bredeweg Steef W 
Published: January 2016

BackgroundVertical ground reaction force (VGRF) parameters have been implicated as a cause of several running-related injuries. However, no systematic review has examined this relationship.AimWe systematically reviewed evidence for a relation between VGRF parameters and specific running-related injuries.MethodsMEDLINE, Web of Science and EMBASE databases were searched. Two independent assessors screened the articles and rated the methodological quality. The 3 key VGRF parameters we measured were vertical loading rate, impact/passive peak (Fz1) and propulsive/active peak (Fz2). Standardised mean differences of these parameters were calculated using a random-effects model. Meta-regression was performed using injury type, study type and methodological quality as factors.ResultsThe search yielded 2016 citations and 18 met the inclusion criteria for the systematic review. The loading rate was higher in studies that included patients with a history of stress fractures and patients with all injury types, both compared with controls. Only studies that included patients with a history of symptoms at the time of kinetic data collection showed higher loading rates overall in cases than in controls. There were no differences between injured subjects and controls for the active and passive peaks of the VGRF.SummaryThe loading rate is higher in respondents with a history of stress fractures than in respondents without running injuries. Owing to the absence of prospective studies on other injury types, it is not possible to draw definite conclusions regarding their relation with loading rate.
Depressive symptoms, life satisfaction and prevalence of sleep disturbances in the general population of Germany: results from the Heinz Nixdorf Recall study
Authors: Lacruz Maria Elena , Schmidt-Pokrzywniak Andrea , Dragano Nico , Moebus Susanne , Deutrich Susanne Eva , Möhlenkamp Stefan , Schmermund Axel , Kaelsch Hagen , Erbel Raimund , Stang Andreas 
Published: January 2016

ObjectivesIt appears that not only depression, but also low life satisfaction (LS), is related to sleep disorder in the general population. We evaluate whether the prevalence of sleep disorder attributable to depressed mood is greater among participants with low LS.Setting, participants and outcome measuresAnalysis of cross-sectional data from 3880 cohort members from the German Heinz Nixdorf Recall study (2006–2008) aged 51–81 years. Standard mood (Center for Epidemiological Studies Depression scale (CES-D) for Depressive symptoms and a single-item life satisfaction measure) and sleep quality (Pittsburgh Sleep Quality Index, PSQI) measures were conducted as part of the survey. Multiple imputation was used to deal with missing data in outcome, exposures or covariates. Relative excess risk for interaction (RERI) and its 95% CIs were estimated using adjusted prevalence ORs. Owing to the study size, the precision of the measures of additive interaction is relatively low.ResultsWe observed an association between depressed mood (5-units increase in CES-D score) (POR=1.7 (95% CI 1.6 to 1.8)) and sleep disorder, and between low LS (not very satisfied vs very satisfied) (POR=1.5 (1.1 to 2.2)) and sleep disorder. Also, we observed a synergistic effect between lower level of LS (not very satisfied) and depressed mood (score ≥16) on prevalence of sleep disorders (RERI=3.7 (−0.2 to 7.1)). Furthermore, these findings were corroborated in sensitivity analysis carried out with the complete case data set and in sex-specific analyses (RERI=5.5 (−0.4 to 11.3), and RERI=2.4 (−2.5 to 7.4) for men and women, respectively).ConclusionsBoth depressed mood and LS are notably associated with sleep quality, and these relationships are best captured by considering their joint effects. Depression and LS need to be taken into consideration when analysing sleep quality.
Is referral of postsurgical colorectal cancer survivors to cardiac rehabilitation feasible and acceptable? A pragmatic pilot randomised controlled trial with embedded qualitative study
Authors: Hubbard Gill , Adams Richard , Campbell Anna , Kidd Lisa , Leslie Stephen J , Munro Julie , Watson Angus 
Published: January 2016

Objectives(1) Assess whether cardiac rehabilitation (CR) is a feasible and acceptable model of rehabilitation for postsurgical colorectal cancer (CRC) survivors, (2) evaluate trial procedures. This article reports the results of the first objective.Design and settingA pragmatic pilot randomised controlled trial with embedded qualitative study was conducted in 3 UK hospitals with CR facilities. Descriptive statistics were used to summarise trial parameters indicative of intervention feasibility and acceptability. Interviews and focus groups were conducted and data analysed thematically.ParticipantsPeople with CRC were considered for inclusion in the trial if they were ≥18 years old, diagnosed with primary CRC and in the recovery period postsurgery (they could still be receiving adjuvant therapy). 31% (n=41) of all eligible CRC survivors consented to participate in the trial. 22 of these CRC survivors, and 8 people with cardiovascular disease (CVD), 5 CRC nurses and 6 CR clinicians participated in the qualitative study.InterventionReferral of postsurgical CRC survivors to weekly CR exercise classes and information sessions. Classes included CRC survivors and people with CVD. CR nurses and physiotherapists were given training about cancer and exercise.ResultsBarriers to CR were protracted recoveries from surgery, ongoing treatments and poor mobility. No adverse events were reported during the trial, suggesting that CR is safe. 62% of participants completed the intervention as per protocol and had high levels of attendance. 20 health professionals attended the cancer and exercise training course, rating it as excellent. Participants perceived that CR increased CRC survivors’ confidence and motivation to exercise, and offered peer support. CR professionals were concerned about CR capacity to accommodate cancer survivors and their ability to provide psychosocial support to this group of patients.ConclusionsCR is feasible and acceptable for postsurgical CRC survivors. A large-scale effectiveness trial of the intervention should be conducted.Trial registration numberISRCTN63510637.
Performance evaluation of the PelvoCheck CT/NG test kit for the detection ofChlamydia trachomatisandNeisseria gonorrhoeae
Authors: Meyer Thomas , Klos Christian , Kofler Regina , Kilic Annett , Hänel Kristina 
Published: January 2016

ObjectiveAssessment of the performance of the PelvoCheck CT/NG test (Greiner-Bio-One GmbH) to detectChlamydia trachomatis(CT) andNeisseria gonorrhoeae(NG) in first-void urine (FVU) of females.DesignA cross-sectional study to compare the PelvoCheck CT/NG with COBAS TaqMan CT Test V.2.0 (Roche) for the detection of CT and with an in-houseporA-based PCR for the detection of NG in FVU specimens. In addition, pools of 5 FVU specimens containing only CT-negative or 1 CT-positive and 4 CT-negative samples were tested. Abbott RealTimeCT/NG was used as an additional test to resolve discordant results.SettingSamples sent from six laboratories were tested at the University Medical Center Hamburg.ParticipantsUrine samples were from 1622 female patients attending gynaecological practices for chlamydia screening, another 120 urine samples were from patients pretested for NG at Synlab, Medical Service Center, Weiden GmbH. In addition, 50 urine samples spiked with various concentrations of reference material were used.ResultsFor the detection of CT and NG, the sensitivity and specificity of the PelvoCheck CT/NG test were 98.8% and 100%, and 98.3% and 98.2%, respectively. The data obtained with the PelvoCheck CT/NG for pooled urine specimens resulted in a positive agreement of 90.9% and a negative agreement of 100%.ConclusionsThe PelvoCheck CT/NG assay is a suitable test method for the detection of CT and NG in female FVU samples, with sensitivity and specificity comparable with other Food and Drug Administration approved CT/NG nucleic acid amplification tests. To the best of our knowledge, this is the first commercial test system validated for the analysis of pooled urine specimens. No false-positive or invalid result was observed in 55 analysed pools. Nevertheless, 5 samples were false negative due to a target concentration below the limit of detection of the PelvoCheck CT/NG test as a consequence of pooling-associated dilution.
Injury prevention exercise programmes in professional youth soccer: understanding the perceptions of programme deliverers
Authors: O'Brien James , Finch Caroline F 
Published: January 2016

BackgroundThere are well-known challenges to implementing injury prevention strategies in amateur soccer, but information from other soccer settings is scarce. This cross-sectional survey analysed the injury prevention perceptions of soccer coaches, fitness coaches and physiotherapists from 4 male teams in a professional youth soccer academy.MethodsThe respondents (n=18) completed a web-based survey relating to lower limb (LL) soccer injuries, the value and practicality of injury prevention exercise programmes (IPEPs) in general and, more specifically, the IPEP endorsed by FIFA, the FIFA 11+.ResultsThere were very high levels of agreement regarding players’ susceptibility to LL injury and the seriousness of these injuries. Respondents agreed unanimously that players should perform evidence-based injury prevention exercises. Despite 61% of respondents having previously heard of the FIFA 11+, just 6% reported current use of the full programme, with a further 22% reporting modified use. 22% believed the FIFA 11+ contained adequate variation and progression for their team and 78% felt it needed improvement. Respondents identified multiple barriers and facilitators to maintaining IPEPs, relating either to the programme content (eg, exercise variation), or the delivery and support of the programme (eg, coach acceptance).ConclusionsThe coaches, fitness coaches and physiotherapists of professional youth teams support the use of IPEPs, but enhancing their impact requires tailoring of programme content, along with adequate delivery and support at multiple levels. The findings suggest that the FIFA 11+ needs modification for use in professional youth soccer teams.
Is there a role for humidified heated high-flow nasal cannula therapy in paediatric emergency departments?
Authors: Long Elliot , Babl Franz E , Duke Trevor 
Published: January 2016

BackgroundHumidified heated high-flow nasal cannula (HFNC) therapy is a potentially useful form of non-invasive respiratory support for children with moderate respiratory distress and/or hypoxaemia. No prospective data support its use in the paediatric emergency department (ED). We introduced HFNC therapy into a paediatric ED and evaluated its use and failure rates.MethodsProspective observational study of all patients presenting to the Royal Children's Hospital, Australia, who received HFNC therapy between April 2013 and September 2013 (one southern hemisphere winter season). We assessed demographics, indications, failure rate, predictors of failure and adverse events.Results71 patients commenced HFNC therapy in ED over the study period. The median age was 9 months. The most common indication was bronchiolitis (49/71; 69%). Five (7%) of the patients failed HFNC and were escalated to other forms of respiratory support in ED, four to nasal continuous positive airway pressure and one required intubation. A further 21 (32%) failed HFNC therapy after intensive care unit (ICU) admission, giving a total failure of 28 (39%). There were no serious adverse events in ED, and one child with asthma developed air leak syndrome after transfer to the ICU.ConclusionsHFNC therapy may have a role in the paediatric ED as an easily administered and well tolerated form of non-invasive respiratory support, but about one-third of patients required escalation to a higher level of respiratory support. Further studies should assess the safety profile of HFNC in larger series, and define the role of HFNC in key respiratory conditions compared with other possible interventions.
Practical applications of injury surveillance: a brief 25-year history of the Connecticut Injury Prevention Center
Authors: Lapidus Garry , Borrup Kevin , DiVietro Susan , Campbell Brendan T , Beebe Rebecca , Grasso Damion , Rogers Steven , Joseph D'Andrea , Banco Leonard 
Published: January 2016

Background:The mission of the Connecticut Injury Prevention Center (CIPC), jointly housed in Connecticut Children's Medical Center and Hartford Hospital, is to reduce unintentional injury and violence among Connecticut residents, with a special focus on translating research into injury prevention programmes and policy. The CIPC engages in four core activities: research, education and training, community outreach programmes and public policy. As surveillance is an essential element of injury prevention, the CIPC has developed a robust statewide fatal and non-fatal injury surveillance system that has guided our prior work and continues to inform our current projects.Objective:The purpose of this article is to review the projects, programmes, and collaborative relationships that have made the CIPC successful in reducing unintentional injury and violence in Connecticut throughout the course of its 25 years history.Design, setting, participants:Retrospective review of the application of injury surveillance.Results/Conclusions:We believe that the application of our surveillance system can serve as a model for others who wish to engage in collaborative, community-based, data-driven injury prevention programmes in their own communities.
Defining acute kidney injury in dengue viral infection by conventional and novel classification systems (AKIN and RIFLE): a comparative analysis
Authors: Mallhi Tauqeer Hussain , Khan Amer Hayat , Sarriff Azmi , Adnan Azreen Syazril , Khan Yusra Habib , Jummaat Fauziah 
Published: January 2016

Abstract

Background
Several criteria have been used to stratify acute kidney injury (AKI) in dengue infection and have resulted in variations in its incidence as well as clinic-laboratory characteristics. The current study was aimed to compare three commonly used criteria of AKI among patients with dengue.

Methods
667 patients with dengue were defined and staged according to the conventional definition (CD), the Acute Kidney Injury Network (AKIN) and the Risk, Injury, Failure, Loss of function, End stage renal disease (RIFLE) criteria. Appropriate statistical methods were used to compare these three criteria.

Results
The incidence of AKI during dengue infection was 14.2% by AKIN criteria, 12.6% by RIFLE criteria and 4.2% by CD. AKIN and RIFLE criteria were comparable while AKIN-I identified 11 more patients with AKI than RIFLE-R (76.8% vs 73.8%, p=0.023). CD was found to be less sensitive than AKIN and RIFLE due to stratification of only severe AKI cases with serum creatinine ≥176.8 µmol/L. Overall mortality was 1.2% and severe stages of AKI were associated with increased mortality (p&lt;0.001). AKIN criteria identified seven risk factors, RIFLE identified six and CD identified three risk factors. Old age, severe dengue and the use of nephrotoxic drugs were found to be independent predictors identified by all criteria while hypertension was only identified by AKIN.

Conclusions
The incidence of AKI in dengue infection, the risk factors for its development and clinico-laboratory characteristics vary significantly according to the diagnostic criteria used. In our analysis, AKIN and RIFLE were comparable to each other and superior to CD with regard to early diagnosis and sensitivity.
Regulation of peripheral classical and non-classical monocytes on infliximab treatment in patients with rheumatoid arthritis and ankylosing spondylitis
Authors: Aeberli Daniel , Kamgang Richard , Balani Deepak , Hofstetter Willy , Villiger Peter M , Seitz Michael 
Published: January 2016

ObjectiveTo investigate the regulatory effect of tumour necrosis factor (TNF) blockade with infliximab on the distribution of peripheral blood monocyte subpopulations in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).MethodsPurified CD11b+CD14+ monocytes from 5 patients with RA and 5 AS were analysed ex vivo before and after infliximab treatment by flow cytometry for CD16, CD163, CD11b, C-C chemokine receptor type 2 (CCR2) and CXC chemokine receptor 4 (CXCR4) at baseline and at days 2, 14, 84 and 168 after the first infliximab administration. Serum levels of the stromal cell-derived factor (SDF)-1 and monocyte chemotactic peptide (MCP)-1 at different time points were measured in either patient group before and on infliximab treatment.ResultsAnti-TNF treatment with infliximab led to a significant increase of circulating CD11b+ non-classical and a concomitantly decrease of CD11b+ classical monocytes, to a decline in SDF-1 levels and reduced expression of CCR2 and CXCR4 on non-classical monocyte subpopulation.ConclusionsOur study shows, that TNFα blockade by infliximab resulted in a dichotomy of the regulation of classical and non-classical monocytes that might have substantial impact on inhibition of osteoclastogenesis and of subsequent juxta-articular bone destruction and systemic bone loss in RA and AS.
The first principle study of electronic and optical properties in rhombohedral BiAlO3
Authors: Tse Geoffrey , Yu Dapeng 
Published: January 2016

We studied the crystal structure of perovskite BiAlO3using ab initio density functional theory (DFT) calculations. Using the atomic positions given by the previous literature, we were able to create a lattice structure using visualization software Material Studio. Such sophisticated structure is found in rhombohedral perovskite system with space group with R3c (#161) and lattice parameter of [Formula: see text], bond angle of [Formula: see text], while treating the exchange–correlation potential with the local density approximations (LDA) method. The calculations were performed to investigate the electronic, optical, elastic and phonon properties.
Accelerating asynchronous programs through event sneak peek
Authors: Chadha Gaurav , Mahlke Scott , Narayanasamy Satish 
Published: January 2016

Asynchronous or event-driven programming is now being used to develop a wide range of systems, including mobile and Web 2.0 applications, Internet-of-Things, and even distributed servers. We observe that these programs perform poorly on conventional processor architectures that are heavily optimized for the characteristics of synchronous programs. Execution characteristics of asynchronous programs significantly differ from synchronous programs as they interleave short events from varied tasks in a fine-grained manner.
This paper proposes the Event Sneak Peek (ESP) architecture to mitigate microarchitectural bottlenecks in asynchronous programs. ESP exploits the fact that events are posted to an event queue before they get executed. By exposing this event queue to the processor, ESP gains knowledge of the future events. Instead of stalling on long latency cache misses, ESP jumps ahead to pre-execute future events and gathers useful information that later help initiate accurate instruction and data prefetches and correct branch mispredictions. We demonstrate that ESP improves the performance of popular asynchronous Web 2.0 applications including Amazon, Google maps, and Facebook, by an average of 16%.
Stash
Authors: Komuravelli Rakesh , Sinclair Matthew D. , Alsop Johnathan , Huzaifa Muhammad , Kotsifakou Maria , Srivastava Prakalp , Adve Sarita V. , Adve Vikram S. 
Published: January 2016

Heterogeneous systems employ specialization for energy efficiency. Since data movement is expected to be a dominant consumer of energy, these systems employ specialized memories (e.g., scratchpads and FIFOs) for better efficiency for targeted data. These memory structures, however, tend to exist in local address spaces, incurring significant performance and energy penalties due to inefficient data movement between the global and private spaces. We propose an efficient heterogeneous memory system where specialized memory components are tightly coupled in a unified and coherent address space. This paper applies these ideas to a system with CPUs and GPUs with scratchpads and caches.
We introduce a new memory organization, stash, that combines the benefits of caches and scratchpads without incurring their downsides. Like a scratchpad, the stash is directly addressed (without tags and TLB accesses) and provides compact storage. Like a cache, the stash is globally addressable and visible, providing implicit data movement and increased data reuse. We show that the stash provides better performance and energy than a cache and a scratchpad, while enabling new use cases for heterogeneous systems. For 4 microbenchmarks, which exploit new use cases (e.g., reuse across GPU compute kernels), compared to scratchpads and caches, the stash reduces execution cycles by an average of 27% and 13% respectively and energy by an average of 53% and 35%. For 7 current GPU applications, which are not designed to exploit the new features of the stash, compared to scratchpads and caches, the stash reduces cycles by 10% and 12% on average (max 22% and 31%) respectively, and energy by 16% and 32% on average (max 30% and 51%).
HEB
Authors: Liu Longjun , Li Chao , Sun Hongbin , Hu Yang , Gu Juncheng , Li Tao , Xin Jingmin , Zheng Nanning 
Published: January 2016

Today, an increasing number of applications and services are being hosted by large-scale data centers. The massive and irregular load surges challenge data center power infrastructures. As a result, power mismatching between supply and demand has emerged as a crucial issue in modern data centers which are either under-provisioned or powered by intermittent power sources. Recent proposals have employed energy storage devices such as the uninterruptible power supply (UPS) systems to address this issue. However, current approaches lack the capacity of efficiently handling the irregular and unpredictable power mismatches.
In this paper, we propose Hybrid Energy Buffering (HEB), the first heterogeneous and adaptive strategy that incorporates super-capacitors (SCs) into existing data centers to dynamically deal with power mismatches. Our techniques exploit diverse energy absorbing characteristics and intelligent load assignment policies to provide efficiency- and scenario- aware power mismatch management. More attractively, our management schemes make the costly energy storage devices more affordable and economical for datacenter-scale usage. We evaluate the HEB design with a real system prototype. Compared with a homogenous battery energy buffering system, HEB could improve energy efficiency by 39.7%, extend UPS lifetime by 4.7X, reduce system downtime by 41% and improve renewable energy utilization by 81.2%. Our TCO analysis shows that HEB manifests high ROI and is able to gain more than 1.9X peak shaving benefit during an 8-years period. It allows datacenters to adapt to various power supply anomalies, thereby improving operational efficiency, resiliency and economy.