bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Antidepressants on Non-Alcoholic Fatty Liver Disease and their Underlying Mechanism
Authors: Peng Hailing , Qing Yumin , Han Liu , Fu Shifeng , Li Jianglei , Wang Siyi , Liu Deliang , Liu Lini , Tan Yuyong 
Published: September 2024

Introduction:
The high prevalence of Non-Alcoholic Fatty Liver Disease
(NAFLD), a chronic progressive disease characterized by hepatic steatosis, poses a serious
burden to human health. Depression and NAFLD share some common pathogenic
mechanisms, and patients with depression are at an increased risk of NAFLD. The drug
mirtazapine is commonly used in the treatment of depression, but it can also cause liver
damage. However, whether mirtazapine induces or aggravates NAFLD remains uncertain.
Thus, we evaluated the risk factors for NAFLD in patients with depression and the
effects of mirtazapine on NAFLD in vitro.

Methods:
Inpatients diagnosed with depression at the Second Xiangya Hospital of Central
South University between 2019 and 2022 were included in this study, and NAFLD
was determined using an abdominal ultrasound examination. The risk factors for the development
of NAFLD in patients with depression were analyzed using logistic regression
analysis. AML-12 and MIHA cell lines were used to observe the effects of mirtazapine
on NAFLD using oil red O staining. RT-qPCR and western blotting were used to
explore the molecular mechanism behind NAFLD development induced by mirtazapine.

Results:
Logistic regression analysis showed that older age, use of mirtazapine or fluoxetine,
longer duration of antidepressant use, and combined hyperlipidemia or T2DM were
risk factors for NAFLD in patients with depression. in vitro experiments revealed a subsequent
increase in the content of intracellular lipid droplets as mirtazapine concentration
increased. Mechanistic studies showed that mirtazapine increased the expressions of
TLR4, MyD88, IFN-γ, IL-1β, IL-6, and TNF-α mRNA in hepatocytes. Moreover, the expressions
of TLR4, MyD88, and p-NF-κB-p65 proteins increased in a dose-dependent
manner.

Conclusion:
Age, antidepressant type, duration of antidepressant use, and comorbidities
could be risk factors for NAFLD in patients with depression. Furthermore, mirtazapine
can cause steatosis in both AML-12 and MIHA cell lines and may promote the development
of NAFLD through the TLR4/MyD88/NF-κB signaling pathway. This study lays a
solid foundation for further research on depression and NAFLD and can contribute to
the prevention and treatment of these two diseases.

result:
Logistic regression analysis showed that older age, use of mirtazapine or fluoxetine, longer duration of antidepressant use, and combined hyperlipidemia or T2DM were risk factors for NAFLD in patients with depression. In vitro experiments revealed a subsequent increase in the content of intracellular lipid droplets as mirtazapine concentration increased. Mechanistic studies showed that mirtazapine increased the expression of TLR4, MyD88, IFN-γ, IL-1β, IL-6, and TNF-α mRNA in hepatocytes and the expression of TLR4, MyD88 and p-NF-κB-p65 proteins in a dose-dependent manner.
A Method for Predicting Allelic Variants of Single Nucleotide Polymorphisms
Authors: Tyagunova Ekaterina Evgenyevna , Zakharov Alexander Sergeevich , Pavlova Galina Valerievna , Ogarkova Daria Alexandrovna , Zhuchenko Natalia Alexandrovna , Gushchin Vladimir  Alexeyevich 
Published: September 2024

Introduction:
Single nucleotide polymorphisms (SNPs) are pivotal in clinical genetics,
serving to link genotypes with disease susceptibility and response to environmental factors, including
pharmacogenetics. They also play a crucial role in population genetics for mapping the human
genome and localizing genes. Despite their utility, challenges arise when molecular genetic studies
yield insufficient or uninformative data, particularly for socially significant diseases. This study
aims to address these gaps by proposing a method to predict allelic variants of SNPs.

Method:
Using quantitative PCR and analyzing body composition data from 150 patients with
their voluntary informed consent, we employed IBM SPSS Statistics 29.0 for data analysis. Our
prototype formula, exemplified by allelic variant ADRB2 (rs1042713) = 0.257 + 0.639 * allelic
variant ADRB2 (rs1042714) - 0.314 * allelic variant ADRB3 (rs4994) + 0.191 * allelic variant
PPARA (rs4253778) - 0.218 * allelic variant PPARD (rs2016520) + 0.027 * body weight +
0.00001 * body weight², demonstrates the feasibility of predicting SNP allelic variants.

Results:
This method holds promise for diverse diseases, including those of significant social impact,
due to its potential to streamline and economize molecular genetic research. Its ability to
stratify disease risk in the absence of complete SNP data makes it particularly compelling for clinical
and laboratory geneticists.

Conclusion:
However, its translation into clinical practice necessitates the establishment of a comprehensive
SNP database, especially for frequently analyzed SNPs within the implementing institution.
The Effectiveness of Gamification in Changing Health-related Behaviors: A Systematic Review and Meta-analysis
Authors: Alzghoul Bashar 
Published: September 2024

Introduction
In the current era, different health issues exist because of the lifestyle we have adopted. Mostly, people suffer from different deadly disorders like diabetes because of their own behavior. Gamification is considered to be a good source to maintain a healthy life. Gamification has benefits over other games as it involves changing the behavior of the individual. It helps in giving support to unhealthy people and by changing their behavior, makes their health better.

Objective
Gamification has several advantages, but little is known about it. In this systematic review, we examined studies that illustrate the benefit of gamification in health and well-being. For this objective, we recognized the benefits of gamification based on existing research and performed a complete literature review of empirical studies on gamification for health and well-being.

Methodology
We collected 30 papers containing empirical evidence on the influence of gaming on health and well-being. The inclusion criteria entailed peer-reviewed articles published from 2012 to 2023. The studies were published in English language and their methodology was randomized controlled trials.

Results
The majority of the studies indicated positive impacts, less than half mixed effects, and some of the evidence was intermediate. The results for health-related behavior were clear, whereas the results for cognitive outcomes were varied. According to the collected information, gamification could promote health and wellness, particularly behaviors related to health. Several studies, however, demonstrated a mixed or neutral influence.

Conclusion
From the findings of the studies, it could be easily stated that gamification helps in changing the behavior of the individual. However, due to fewer studies used in the review and due to restrictions in certain limits in articles, it could not clearly be concluded that gamification provides the same response in individuals of varying ages. A greater number of studies should be included, and the findings should be carefully examined to know clearly about the effect of gamification in response to the changing behavior of individuals of varying ages.
Pengaruh Ambassador Characteristics, Store Design, Dan Electronic Word of Mouth Terhadap Brand Image
Authors: Lavennia Shella , Handrito Radityo Putro 
Published: September 2024

The goal of this quantitative explanatory research is to identify the effects of ambassador characteristics, store design, and electronic word-of-mouth on the brand image of affordable luxury brands. Using non-probability sampling method and purposive sampling technique, 340 people with the minimum age of eighteen years who know about brands considered as affordable luxury ones, who have visited the store of those brands during the last one year, and who have accessed information about those brands via social media were selected as the respondents. The data analysis was conducted in SPSS 25 by applying multiple linear regression. This study finds that (1) ambassador characteristics positively and significantly influence brand image, (2) that store design has no effect on the brand image, and that (3) electronic word-of-mouth positively and significantly influences the brand image.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh ambassador characteristics, store design, dan electronic word of mouth terhadap brand image affordable luxury brands. Penelitian ini menggunakan jenis penelitian eksplanatori dengan metode kuantitatif. Teknik sampling yang digunakan adalah non-probability sampling dengan metode purposive kepada 340 responden. Karakteristik dari responden penelitian merupakan generasi milenial dan generasi z dengan usia minimal 18 tahun yang mengetahui merek-merek yang termasuk ke dalam affordable luxury, pernah mengunjungi toko dari merek affordable luxury dalam kurun waktu satu tahun terakhir, dan pernah mengakses informasi mengenai merek affordable luxury melalui media sosial. Penelitian ini menggunakan software SPSS 25 dengan melakukan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa (1) variabel ambassador characteristics berpengaruh positif dan signifikan terhadap brand image, (2) variabel store design tidak berpengaruh terhadap brand image, dan (3) variabel electronic word of mouth berpengaruh positif dan signifikan terhadap brand image.
Pengaruh Relationship Marketing Dan Customer Perceived Value Terhadap Repurchase Intention Dimediasi Oleh Customer Loyalty
Authors: Marpaung Putri Nauli , Arif Moh. Erfan 
Published: September 2024

The objective of this study is to identify and explain the effect of relationship marketing and perceived value on repurchase intention, the effect of relationship marketing and perceived value on customer loyalty, the effect of customer loyalty on repurchase intention, and the mediation role of customer loyalty. Using purposive sampling technique, 190 people with the minimum age of sixteen years who had bought the products of Emina more than once were selected as the respondents. The data of this explanatory research was acquired from Likert-scaled questionnaires and processed using path analysis in SPSS ver. 25. This study finds that relationship marketing does not significantly affect repurchase intention, perceived value significantly affects repurchase intention, relationship marketing significantly affects customer loyalty, perceived value significantly affects customer loyalty, customer loyalty significantly affects repurchase intention, customer loyalty mediates the effect of relationship marketing on repurchase intention, and that customer loyalty mediates the effect of perceived value on repurchase intention.

Abstrak
Penelitian ini bertujuan untuk mengetahui dan menjelaskan pengaruh relationship marketing dan perceived value terhadap repurchase intention, pengaruh relationship marketing dan perceived value terhadap customer loyalty, pengaruh customer loyalty terhadap repurchase intention, dan peran mediasi dari customer loyalty. Penelitian ini merupakan penelitian explanatory research dengan menggunakan kuesioner bersekala likert sebagai alat pengumpulan data. Pengumpulan sampel menggunakan teknik purposive sampling dengan karakteristik responden wanita berusia > 16 tahun dan telah membeli produk Emina lebih dari satu kali. Jumlah sampel yang digunakan dalam penelitian ini adalah sebanyak 190 responden. Data yang didapat kemudian diolah menggunakan software SPSS ver.25 menggunakan analisis jalur. Hasil penelitian ini menunjukan bahwa tidak terdapat pengaruh yang signifikan relationship marketing terhadap repurchase intention, terdapat pengaruh signifikan perceived value terhadap repurchase intention, Terdapat pengaruh signifikan relationship marketing terhadap customer loyalty, Terdapat pengaruh signifikan perceived value terhadap customer loyalty, Terdapat pengaruh signifikan customer loyalty terhadap repurchase intention, Customer loyalty dapat memediasi hubungan relationship marketing dan repurchase intention, dan Customer loyalty dapat memediasi hubungan perceived value dan repurchase intention.
Rancang Bangun Sistem TOBAT (Tepat Obat) pada Pasien Geriatri Berbasis IoT
Authors: Alfi Ikrima 
Published: September 2024

Pasien Geriatri merupakan pasien lansia yang memiliki berbagai macam penyakit akibat penurunan fungsi organ dan biasanya membutuhkan pengobatan jangka panjang. Permasalahan pada pasien geriatri adalah kemampuan dalam mengingat. Banyak pasien geriatri yang tidak didampingi keluarga atau care giver sepanjang waktu, sehingga tidak ada yang mengingatkan pasien untuk minum obat. Kondisi yang lebih fatal adalah pasien sudah minum obat namun merasa belum meminumnya, sehingga minum obat lagi. Hal ini dapat menyebabkan over dosis. Perkembangan teknologi saat ini telah memunculkan inovasi dan solusi baru untuk menciptakan kemudahan dalam berbagai bidang diantaranya adalah teknologi IoT. Aplikasi IoT diantaranya dapat digunakan untuk monitoring dan memberikan notifikasi pengingat minum obat pada pasien geriatri (lansia). Penelitian ini membuat alat/kotak obat untuk membantu pasien geriatri minum obat tepat waktu dan tepat dosis (sistem TOBAT) berbasis IoT. Aplikasi Blynk digunakan untuk setting waktu pemberian obat. Pada waktu yang telah ditetapkan, sistem ini akan menyalakan lampu indikator dan membuka kotak obat secara otomatis pada kotak obat yang sesuai serta menyalakan alarm. Sistem TOBAT juga akan memberi konfirmasi melalui telegram kepada keluarga atau caregiver bila sudah waktunya minum obat dan obat telah diminum. Hasil pengujian menunjukkan semua komponen telah bekerja 100% (error 0%) namun terdapat delay pada selenoid sekitar 1-2 detik, pada LED dan buzzer sekitar 2-3 detik. Pengiriman pada notif-1 “Waktunya minum obat!” terdapat delay sekitar 3-6 detik. Pada notif-2 “Obat pagi/siang/malam sudah diminum” terdapat delay sekitar 3-6 detik.
Implementasi Logika Fuzzy Terhadap Kontrol dan Monitoring Pada Konsumsi Energi Listrik Rumah Tangga
Authors: Rofiq Muhammad Ainur , Sirait Fadli , Sebayang Ika Sari Damayanthi , Pangaribowo Triyanto , Supegina Fina , Attamimi Said , Husodo Budi Yanto , Pradana Hapril Arief 
Published: September 2024

Energi listrik memiliki peran vital pada seluruh sektor kehidupan. Sektor rumah tangga mengkonsumsi energi listrik paling besar berdasarkan data tahunan PLN 2021. Meningkatnya populasi manusia ditambah penggunaan energi listrik yang tidak tepat memperbesar nilai konsumsi rumah tangga. Standby power adalah salah satu efek yang ditimbulkannya. Standby power dapat dihindari dengan memutus beban listrik dari sumber listrik jika tidak digunakan. Penelitian ini merancang alat bantu untuk efisiensi konsumsi listrik pada beban listrik rumah tangga dengan cara meminimalisir konsumsi listrik akibat standby power dengan menerapkan sistem fuzzy logic mamdani. Sensor PZEM-004T berfungsi mengukur besaran listrik, nodeMCU ESP8266 sebagai pengolah data dan Blynk Iot sebagai interface monitoring dan kontrol. Arus dan daya listrik digunakan sebagai variable input fuzzy logic. Rules fuzzy dirancang untuk mendeteksi kondisi beban , jika beban dalam mode aktif output fuzzy berupa kondisi relay close, jika beban dalam kondisi standby output fuzzy berupa kondisi relay open. Beban listrik yng digunakan untuk uji coba meliputi TV 32”, AC, komputer, kipas angin dan laptop . Perkiraan nilai efisiensi yang dihasilkan dalam rentang waktu 1 tahun pada beban TV 7,26% ,komputer 2,12%, AC 0,26% dan kipas angin 0% dikarenakan kipas angin tidak memiliki mode standby. Nilai efisiensi pada beban laptop adalah perbandingan pola penggunaan harian yang diakumulasikan selama 1 tahun dengan pola penggunaan A akan menghasilkan efisiensi konsumsi energi listrik sebesar 37,9% dibandingkan pola penggunaan B
Desain Sistem Kontrol Level Deaerator Menggunakan Kontrol Cascade dan Logika Fuzzy di Pembangkit Listrik Tenaga Uap Muara Karang
Authors: Ramadhan Muhamad Husen , Andika Julpri 
Published: September 2024

Deaerator storage tank merupakan salah satu komponen yang terdapat pada Pusat Listrik Tenaga Uap atau bisa disingkat PLTU. Deaerator merupakan bagian dari sistem air pengisi boiler. Dearator memiliki fungsi utama untuk menghilangkan gas (terutama okisgen) sebelum memasuki boiler agar peralatan pembangkit terutama tube – tube pada boiler terhidar dari korosi. Sistem kerja deaerator bekerja secara kontinyu, sehigga level air deaerator harus tetap dijaga untuk dapat memenuhi kebutuhan boiler. Perlu diterapkan pengendalian level air deaerator dan kestabilan sistem deaerator menggunakan metode fuzzy control. Hasil penelitian dengan menggunakan fuzzy logic control menunjukan respon dapat mencapai nialai set point dan dapat menjaga kestabilan. Dengan nilai parameter sebagai berikut settling time (ts) sebesar 302.337 detik, rise time (tr) sebesar 145.907 detik, error steady state (ess) sebesar 0.4 % dan maximum overshoot sebesar 1.329%.
Olhares e conexões culturais sobre o Caruru do ODEERE
Authors: Argolo Silva Neto Antonio 
Published: September 2024

Este artigo apresenta um relato de experiência a partir de fotografias dos festejos do Caruru do ODEERE/UESB com vistas às demandas do grupo de pesquisa em Linguagens Visuais e Cultura, na época vinculado ao Programa de Pós-Graduação em Desenho, Cultura e Interatividade (PPGDCI) da Universidade Estadual de Feira de Santana (UEFS). O propósito é a documentação visual e dialogar com as imagens do caruru do ODEERE na busca de significados culturais, que se ancoram nos legados dos povos afro-brasileiros. Esses festejos acontecem na última semana de setembro, celebração sincrética de Cosme e Damião, Erês, Wunjes e Ibejis. O evento de influência religiosa, mantém o cunho de festas populares para atender as atividades acadêmicas de pesquisas e extensão. Oportunidade quando a comunidade tradicional, professores, alunos e a população em geral comparecem ao banquete, contribuindo com seu brilho e diversidade. A metodologia utilizada foi a Antropologia Visual, relatos construídos pela observação participante e registros fotográficos. Os resultados permitem identificar elementos simbólicos que protagonizam sincretismo religioso, com vistas às manifestações culturais do legado africano; bem como o significado cultural da imagem e fotografias que acompanham a evolução dos festejos.
Acute Thrombosis of Lower Extremities Veins in Surgical Patients With COVID-19
Authors: Vlasov A. P. , Shchapov V. V. , Vlasova T. I. , Al-Kubaisi Sh. S. , Leshchankina N. Yu. , Myshkina N. A. , Sitdikov I. I. , Kormishkin A. E. , Sitdikova A. V. , Rubtsov O. Yu. 
Published: September 2024

AIM OF THE STUDY. To establish the incidence of acute thrombosis of the veins of the lower extremities and the activity of the most significant trigger agents that led to this complication in patients with a new coronavirus infection. MATERIAL AND METHODS. The clinical section of the work is presented by observations of 123 patients with acute surgical pathology and thrombosis of the veins of the lower extremities. The first group (comparison) (n = 48) included patients with thrombosis of the veins of the lower extremities, the second (studied) group (n = 87) included patients with a similar problem that arose against the background of coronavirus infection. All patients underwent surgical interventions: thrombectomy and plication. Before surgery, on the 1st, 4th and 7th days after surgery, disorders of the hemostasis system, the severity of endogenous intoxication syndrome, and lipid metabolism were assessed. RESULTS. Damage to the veins of the lower extremities in patients with acute surgical pathology and new coronavirus infection occurs much more often, in 8.04 % of cases, than in such patients without COVID-19, in 0.76% (χ2 = 252.5, p < 0.001). Of the 87 patients with acute venous thrombosis of the inferior vena cava system and COVID-19, 63 patients (72.41 %) were operated on. In the early postoperative period, venous rethmbosis occurred in 11 (17.5 %) patients. The mortality rate was 6.3 %. According to thromboelastography, in the main group the values of such parameters as reactive time, the growth rate of the fibrin network and its structure formation and the maximum strength of the clot were statistically significantly higher than in the control group, which indicates the predominance of hypercoagulation in these patients. Patients in this group showed more significant phenomena of endotoxemia, oxidative stress and activation of phospholipases. CONCLUSION. With a new coronavirus infection, surgical patients have a high probability of developing threatening thrombohemorrhagic complications. The most important trigger for their occurrence is significant disturbances in the hemostatic system, which are generally characterized by an increased ability of the blood to form thrombosis against the background of a decrease in its fibrinolytic activity. Disturbances in the hemostatic system occurred against the background of oxidative stress, activation of phospholipases and endotoxemia. The obtained material is proof of the significance of the new coronavirus COVID-19 infection worsens coagulopathy, which plays an important role in the pathogenesis of the disease in general and the development of complications.
Analysis of the Detection Rate and Results of Surgical Treatment of Patients with Infective Endocarditis With/Without COVID-19
Authors: Vladimirov V. V. , Abdullaeva M. M. , Selyaev V. S. , Kokov L. S. , Redkoborody A. V. , Kambarov S. Yu. , Ivanov I. V. , Kovalev A. I. , Popugayev K. A. 
Published: September 2024

AIM OF STUDY. To analyze results of surgical treatment of infective endocarditis in the context of the COVID-19 pandemic at the N. V. Sklifosovsky Research Institute for Emergency Medicine. MATERIAL AND METHODS. From January, 2021 to April, 2022 at N.V. Sklifosovsky Research Institute for Emergency Medicine we performed 59 surgical interventions on patients diagnosed with infective endocarditis, of which 20 patients (33.9%) had a competing diagnosis “new coronavirus infection”. RESULTS. The overall mortality was for the specified period was 18.6 %, 11 patients. In the first group, 5 patients died (25 %). Hospital mortality in the second group was 6 patients (15.4 %). CONCLUSION. Preoperative preparation, as well as the surgical intervention itself, did not differ significantly between patients in the two groups. Hospital mortality in the group of patients with new coronavirus infection was higher than in patients without the virus, despite the fact that the risk of surgical intervention according to EuroSCORE II was higher in the second group. From which we can conclude that the EuroSCORE risk scale II does not fully reflect the initial severity of the condition of patients with COVID-19. Such risk factors as decreased immunity due to immunosuppressive therapy and respiratory failure and coagulopathy influenced the results of surgical treatment of infective endocarditis in this cohort of patients, but not so significantly as to refuse surgical intervention. The significant difference in the postoperative period was the increase in bed days in intensive care and therapeutic departments among patients with COVID-19. This factor is associated with the initial severity and specifics of management of these patients in the postoperative period, which required greater vigilance and attention from cardiac surgeons, resuscitators and infectious disease doctors in the “red” zones.