bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ontario Neurodegenerative Disease Research Initiative (ONDRI)
Authors: Farhan Sali M. K. , Bartha Robert , Black Sandra E. , Corbett Dale , Finger Elizabeth , Freedman Morris , Greenberg Barry , Grimes David A. , Hegele Robert A. , Hudson Chris , Kleinstiver Peter W. , Lang Anthony E. , Masellis Mario , McIlroy William E. , McLaughlin Paula M. , Montero-Odasso Manuel , Munoz David G. , Munoz Douglas P. , Strother Stephen , Swartz Richard H. , Symons Sean , Tartaglia Maria Carmela , Zinman Lorne ,   ONDRI Investigators, Strong Michael J. 
Published: December 2016

AbstractBecause individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson’s disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.
Vapour explosion under hot water depressurization
Authors: Ivashnyov Oleg E. , Ivashneva Marina N. 
Published: December 2016

This paper continues a series of works developing a model for a high-speed boiling flow capable of describing different fluxes with no change in the model coefficients. Refining the interfacial area transport equation in partial derivatives, we test the ability of the model to describe phenomena that cannot be simulated by models that average the interfacial interaction. In the previous version, the possibility for bubble fragmentation was considered, which permitted us to reproduce an explosive boiling in rarefaction shocks moving at a speed of ${\sim}10~\text{m}~\text{s}^{-1}$ fixed in experiments on hot water decompression. The shocks were shown to be caused by a chain bubble fragmentation leading to a sharp increase in the interphase area (Ivashnyov et al., J. Fluid Mech., vol. 413, 2000, pp. 149–180). With no change in the free parameters (the initial number of boiling centres in the flow bulk and the critical Weber number) chosen for a tube decompression, the model gave close predictions for critical flows in long nozzles, $L/D\sim 100$. The formation of a boiling shock in the nozzle was shown to be the reason for the onset of autovibrated regimes (Ivashnyov & Ivashneva, J. Fluid Mech., vol. 710, 2012, pp. 72–101). However, the previous model does not simulate the phenomenon of a vapour explosion at a primary stage of a hot water decompression, when the first rarefaction wave is followed by an extended, 1 m width, several MPa amplitude compression wave in which the pressure reaches a plateau below a saturation value. The model proposed assumes initial boiling centre origination at the channel walls. Due to overflowing, the wall bubbles break up, with their fragments passing into the flow. On growing up, the flow bubbles can break up in their turn. It is shown that an extended compression wave is caused by the fragmentation of wall bubbles, which leads to the increase in the interphase area, boiling intensification and the pressure rise. The pressure reaches a plateau before a saturation state is reached due to flow momentum loss accelerating the fragments of wall bubbles. The phenomenon of pressure ‘oscillation’ fixed in some experimental oscillograms when the pressure in the compression wave increases up to a saturation pressure and then drops to the plateau value has been explained as well. The ‘illposedness’ defect of the generally accepted model for two-phase two-velocity flow with a compressible carrying phase, which lies in its complex characteristics, has been rectified. The calculations of a stationary countercurrent liquid-particle flow in a diffuser with the improved hyperbolic model predicts a critical regime with a maximal liquid mass flux, while the old non-hyperbolic model simulates the supercritical regimes with ‘numerical instabilities’. Calculations of a transient upward flow of particles have shown the formation of a superslow ‘creeping’ shock wave of particles compacting.
Market Orientation, Growth Strategy, and Firm Performance: The Moderating Effects of External Connections
Authors: Filatotchev Igor , Su Zhongfeng , Bruton Garry D. 
Published: December 2016

ABSTRACTThis study examines the mediating effect of growth strategy (including market and product expansion strategies) on the linkage of market orientation (MO) to firm performance and the moderating effects of a firm's external connections (including political and business ties) on the relationship between MO and growth strategy. It finds that both market and product expansion strategies are key conduits through which MO improves firm performance. In addition, the relationship between MO and market expansion strategy is positively moderated by political ties but negatively moderated by business ties, while the linkage of MO to product expansion strategy is moderated negatively by political ties but positively by business ties. By combining mediating and moderating effects in a framework that integrates MO, growth strategy, external connections, and firm performance, this study enriches our knowledge on the implications of MO and provides insight into factors that facilitate firm growth.
Frontier methods in coherent X-ray diffraction for high-resolution structure determination
Authors: Gallagher-Jones Marcus , Rodriguez Jose A. , Miao Jianwei 
Published: December 2016

AbstractIn 1912, Max von Laue and collaborators first observed diffraction spots from a millimeter-sized crystal of copper sulfate using an X-ray tube. Crystallography was born of this experiment, and since then, diffraction by both X-rays and electrons has revealed a myriad of inorganic and organic structures, including structures of complex protein assemblies. Advancements in X-ray sources have spurred a revolution in structure determination, facilitated by the development of new methods. This review explores some of the frontier methods that are shaping the future of X-ray diffraction, including coherent diffractive imaging, serial femtosecond X-ray crystallography and small-angle X-ray scattering. Collectively, these methods expand the current limits of structure determination in biological systems across multiple length and time scales.
Plasma scale length effects on protons generated in ultra-intense laser–plasmas
Authors: Culfa O. , Tallents G.J. , Korkmaz M.E. , Rossall A.K. , Wagenaars E. , Ridgers C.P. , Murphy C.D. , Booth N. , Carroll D.C. , Wilson L.A. , Lancaster K.L. , Woolsey N.C. 
Published: December 2016

AbstractThe energy spectra of protons generated by ultra-intense (1020 W cm−2) laser interactions with a preformed plasma of scale length measured by shadowgraphy are presented. The effects of the preformed plasma on the proton beam temperature and the number of protons are evaluated. Two-dimensional EPOCH particle-in-cell code simulations of the proton spectra are found to be in agreement with measurements over a range of experimental parameters.
Laser ion implantation of Ge in SiO2 using a post-ion acceleration system
Authors: Cutroneo M. , Mackova A. , Torrisi L. , Lavrentiev V. 
Published: December 2016

AbstractThis work reports a comparative study of laser ion implantation mainly performed at the Nuclear Physics Institute in Rez (Czech Republic), National Institute of Nuclear Physics (Italy), and the Plasma Physics Laboratory at the University of Messina (Italy) using different approaches. Thick metallic targets were irradiated in vacuum by a focused laser beam to generate plasma-producing multi-energy and multi-species ions. A post-acceleration system was employed in order to increase the energy of the produced ions and to generate ion beams suitable to be implanted in different substrates. The ion dose was controlled by the laser repetition rate and the time of irradiation. Rutherford backscattering analysis was carried out to evaluate the integral amount of implanted ion species, the concentration–depth profiles, the ion penetration depth, and the uniformity of depth profiles for ions laser implanted into monocrystalline substrates. The laser implantation under normal conditions and in post-acceleration configuration will be discussed on the basis of the characterization of the implanted substrates.
The RANTANPLAN planner: system description
Authors: Bofill Miquel , Espasa Joan , Villaret Mateu 
Published: December 2016

AbstractRANTANPLAN is a numeric planning solver that takes advantage of recent advances in satisfiability modulo theories. It extends reduction to SAT approaches with an easy and efficient handling of numeric fluents using background theories. In this paper, we describe the design choices and features of RANTANPLAN, especially, how numeric reasoning is integrated in the system. We also provide experimental results showing that RANTANPLAN is competitive with existing exact numeric planners.
Age- and time-dependent prevalence and incidence of hepatitis C virus infection in drug users in France, 2004–2011: model-based estimation from two national cross-sectional serosurveys
Authors: LEON L. , KASEREKA S. , BARIN F. , LARSEN C. , WEILL-BARILLET L. , PASCAL X. , CHEVALIEZ S. , PILLONEL J. , JAUFFRET-ROUSTIDE M. , LE STRAT Y. 
Published: December 2016

SUMMARYHepatitis C virus (HCV) infection is a public health issue worldwide. Injecting drug use remains the major mode of transmission in developed countries. Monitoring the HCV transmission dynamic over time is crucial, especially to assess the effect of harm reduction measures in drug users (DU). Our objective was to estimate the prevalence and incidence of HCV infection in DU in France using data from a repeated cross-sectional survey conducted in 2004 and 2011. Age- and time-dependent HCV prevalence was estimated through logistic regression models adjusted for HIV serostatus or injecting practices. HCV incidence was estimated from a mathematical model linking prevalence and incidence. HCV prevalence decreased from 58·2% [95% confidence interval (CI) 49·7–66·8] in 2004 to 43·2% (95% CI 38·8–47·7) in 2011. HCV incidence decreased from 7·9/100 person-years (95% CI 6·4–9·4) in 2004 to 4·4/100 person-years (95% CI 3·3–5·9) in 2011. HCV prevalence and incidence were significantly associated with age, calendar time, HIV serostatus and injecting practices. In 2011, the highest estimated incidence was in active injecting DU (11·2/100 person-years). Given the forthcoming objective of generalizing access to new direct antiviral agents for HCV infection, our results contribute to decision-making and policy development regarding treatment scale-up and disease prevention in the DU population.
Med Diet 4.0: the Mediterranean diet with four sustainable benefits
Authors: Dernini S , Berry EM , Serra-Majem L , La Vecchia C , Capone R , Medina FX , Aranceta-Bartrina J , Belahsen R , Burlingame B , Calabrese G , Corella D , Donini LM , Lairon D , Meybeck A , Pekcan AG , Piscopo S , Yngve A , Trichopoulou A 
Published: December 2016

AbstractObjectiveTo characterize the multiple dimensions and benefits of the Mediterranean diet as a sustainable diet, in order to revitalize this intangible food heritage at the country level; and to develop a multidimensional framework – the Med Diet 4.0 – in which four sustainability benefits of the Mediterranean diet are presented in parallel: major health and nutrition benefits, low environmental impacts and richness in biodiversity, high sociocultural food values, and positive local economic returns.DesignA narrative review was applied at the country level to highlight the multiple sustainable benefits of the Mediterranean diet into a single multidimensional framework: the Med Diet 4.0.Setting/subjectsWe included studies published in English in peer-reviewed journals that contained data on the characterization of sustainable diets and of the Mediterranean diet. The methodological framework approach was finalized through a series of meetings, workshops and conferences where the framework was presented, discussed and ultimately refined.ResultsThe Med Diet 4.0 provides a conceptual multidimensional framework to characterize the Mediterranean diet as a sustainable diet model, by applying principles of sustainability to the Mediterranean diet.ConclusionsBy providing a broader understanding of the many sustainable benefits of the Mediterranean diet, the Med Diet 4.0 can contribute to the revitalization of the Mediterranean diet by improving its current perception not only as a healthy diet but also a sustainable lifestyle model, with country-specific and culturally appropriate variations. It also takes into account the identity and diversity of food cultures and systems, expressed within the notion of the Mediterranean diet, across the Mediterranean region and in other parts of the world. Further multidisciplinary studies are needed for the assessment of the sustainability of the Mediterranean diet to include these new dimensions.
Origin of stabilization and destabilization in solid-state redox reaction of oxide ions for lithium-ion batteries
Authors: Yabuuchi Naoaki , Nakayama Masanobu , Takeuchi Mitsue , Komaba Shinichi , Hashimoto Yu , Mukai Takahiro , Shiiba Hiromasa , Sato Kei , Kobayashi Yuki , Nakao Aiko , Yonemura Masao , Yamanaka Keisuke , Mitsuhara Kei , Ohta Toshiaki 
Published: December 2016

AbstractFurther increase in energy density of lithium batteries is needed for zero emission vehicles. However, energy density is restricted by unavoidable theoretical limits for positive electrodes used in commercial applications. One possibility towards energy densities exceeding these limits is to utilize anion (oxide ion) redox, instead of classical transition metal redox. Nevertheless, origin of activation of the oxide ion and its stabilization mechanism are not fully understood. Here we demonstrate that the suppression of formation of superoxide-like species on lithium extraction results in reversible redox for oxide ions, which is stabilized by the presence of relatively less covalent character of Mn4+ with oxide ions without the sacrifice of electronic conductivity. On the basis of these findings, we report an electrode material, whose metallic constituents consist only of 3d transition metal elements. The material delivers a reversible capacity of 300 mAh g−1 based on solid-state redox reaction of oxide ions.
Evidence for ion migration in hybrid perovskite solar cells with minimal hysteresis
Authors: Calado Philip , Telford Andrew M. , Bryant Daniel , Li Xiaoe , Nelson Jenny , O’Regan Brian C. , Barnes Piers R.F. 
Published: December 2016

AbstractIon migration has been proposed as a possible cause of photovoltaic current–voltage hysteresis in hybrid perovskite solar cells. A major objection to this hypothesis is that hysteresis can be reduced by changing the interfacial contact materials; however, this is unlikely to significantly influence the behaviour of mobile ionic charge within the perovskite phase. Here, we show that the primary effects of ion migration can be observed regardless of whether the contacts were changed to give devices with or without significant hysteresis. Transient optoelectronic measurements combined with device simulations indicate that electric-field screening, consistent with ion migration, is similar in both high and low hysteresis CH3NH3PbI3 cells. Simulation of the photovoltage and photocurrent transients shows that hysteresis requires the combination of both mobile ionic charge and recombination near the perovskite-contact interfaces. Passivating contact recombination results in higher photogenerated charge concentrations at forward bias which screen the ionic charge, reducing hysteresis.
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
Authors: Damas Nkerorema Djodji , Marcatti Michela , Côme Christophe , Christensen Lise Lotte , Nielsen Morten Muhlig , Baumgartner Roland , Gylling Helene Maria , Maglieri Giulia , Rundsten Carsten Friis , Seemann Stefan E. , Rapin Nicolas , Thézenas Simon , Vang Søren , Ørntoft Torben , Andersen Claus Lindbjerg , Pedersen Jakob Skou , Lund Anders H. 
Published: December 2016

AbstractWe currently have limited knowledge of the involvement of long non-coding RNAs (lncRNAs) in normal cellular processes and pathologies. Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arrest and apoptosis in vitro and limits tumour outgrowth in vivo, whereas SNHG5 overexpression counteracts oxaliplatin-induced apoptosis. Using an unbiased approach, we identify 121 transcript sites interacting with SNHG5 in the cytoplasm. Importantly, knockdown of key SNHG5 target transcripts, including SPATS2, induces apoptosis and thus mimics the effect seen following SNHG5 depletion. Mechanistically, we suggest that SNHG5 stabilizes the target transcripts by blocking their degradation by STAU1. Accordingly, depletion of STAU1 rescues the apoptosis induced after SNHG5 knockdown. Hence, we characterize SNHG5 as a lncRNA promoting tumour cell survival in colorectal cancer and delineate a novel mechanism in which a cytoplasmic lncRNA functions through blocking the action of STAU1.
Reprogramming the immunological microenvironment through radiation and targeting Axl
Authors: Aguilera Todd A. , Rafat Marjan , Castellini Laura , Shehade Hussein , Kariolis Mihalis S. , Hui Angela Bik-Yu , Stehr Henning , von Eyben Rie , Jiang Dadi , Ellies Lesley G. , Koong Albert C. , Diehn Maximilian , Rankin Erinn B. , Graves Edward E. , Giaccia Amato J. 
Published: December 2016

AbstractIncreasing evidence suggests that ionizing radiation therapy (RT) in combination with checkpoint immunotherapy is highly effective in treating a subset of cancers. To better understand the limited responses to this combination we analysed the genetic, microenvironmental, and immune factors in tumours derived from a transgenic breast cancer model. We identified two tumours with similar growth characteristics but different RT responses primarily due to an antitumour immune response. The combination of RT and checkpoint immunotherapy resulted in cures in the responsive but not the unresponsive tumours. Profiling the tumours revealed that the Axl receptor tyrosine kinase is overexpressed in the unresponsive tumours, and Axl knockout resulted in slower growth and increased radiosensitivity. These changes were associated with a CD8+ T-cell response, which was improved in combination with checkpoint immunotherapy. These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.
Environmental variation and the evolution of large brains in birds
Authors: Sayol Ferran , Maspons Joan , Lapiedra Oriol , Iwaniuk Andrew N. , Székely Tamás , Sol Daniel 
Published: December 2016

AbstractEnvironmental variability has long been postulated as a major selective force in the evolution of large brains. However, assembling evidence for this hypothesis has proved difficult. Here, by combining brain size information for over 1,200 bird species with remote-sensing analyses to estimate temporal variation in ecosystem productivity, we show that larger brains (relative to body size) are more likely to occur in species exposed to larger environmental variation throughout their geographic range. Our reconstructions of evolutionary trajectories are consistent with the hypothesis that larger brains (relative to body size) evolved when the species invaded more seasonal regions. However, the alternative—that the species already possessed larger brains when they invaded more seasonal regions—cannot be completely ruled out. Regardless of the exact mechanism, our findings provide strong empirical support for the association between large brains and environmental variability.
First molecular and isotopic evidence of millet processing in prehistoric pottery vessels
Authors: Heron Carl , Shoda Shinya , Breu Barcons Adrià , Czebreszuk Janusz , Eley Yvette , Gorton Marise , Kirleis Wiebke , Kneisel Jutta , Lucquin Alexandre , Müller Johannes , Nishida Yastami , Son Joon-ho , Craig Oliver E. 
Published: December 2016

AbstractAnalysis of organic residues in pottery vessels has been successful in detecting a range of animal and plant products as indicators of food preparation and consumption in the past. However, the identification of plant remains, especially grain crops in pottery, has proved elusive. Extending the spectrum is highly desirable, not only to strengthen our understanding of the dispersal of crops from centres of domestication but also to determine modes of food processing, artefact function and the culinary significance of the crop. Here, we propose a new approach to identify millet in pottery vessels, a crop that spread throughout much of Eurasia during prehistory following its domestication, most likely in northern China. We report the successful identification of miliacin (olean-18-en-3β-ol methyl ether), a pentacyclic triterpene methyl ether that is enriched in grains of common/broomcorn millet (Panicum miliaceum), in Bronze Age pottery vessels from the Korean Peninsula and northern Europe. The presence of millet is supported by enriched carbon stable isotope values of bulk charred organic matter sampled from pottery vessel surfaces and extracted n-alkanoic acids, consistent with a C4 plant origin. These data represent the first identification of millet in archaeological ceramic vessels, providing a means to track the introduction, spread and consumption of this important crop.
Anisotropic optical response of optically opaque elastomers with conductive fillers as revealed by terahertz polarization spectroscopy
Authors: Okano Makoto , Watanabe Shinichi 
Published: December 2016

AbstractElastomers are one of the most important materials in modern society because of the inherent viscoelastic properties due to their cross-linked polymer chains. Their vibration-absorbing and adhesive properties are especially useful and thus utilized in various applications, for example, tires in automobiles and bicycles, seismic dampers in buildings, and seals in a space shuttle. Thus, the nondestructive inspection of their internal states such as the internal deformation is essential in safety. Generally, industrial elastomers include various kinds of additives, such as carbon blacks for reinforcing them. The additives make most of them opaque in a wide spectral range from visible to mid-infrared, resulting in that the nondestructive inspection of the internal deformation is quite difficult. Here, we demonstrate transmission terahertz polarization spectroscopy as a powerful technique for investigating the internal optical anisotropy in optically opaque elastomers with conductive additives, which are transparent only in the terahertz frequency region. The internal deformation can be probed through the polarization changes inside the material due to the anisotropic dielectric response of the conductive additives. Our study about the polarization-dependent terahertz response of elastomers with conductive additives provides novel knowledge forin situ, nondestructive evaluation of their internal deformation.