bluuebunny/crossref_metadata_2025_split huggingface dataset:
How can we accept ‘our’ decisions?: an experimental study on lottocracy, epistocracy, and electoral democracy
Authors: Yamaguchi Akito , Hata Masaki , Inoue Akira 
Published: October 2024

AbstractLottocracy and epistocracy have received deeply insightful attention as political regimes. Herein, by conducting an experiment using an online survey, we explored the extent to which public opinion is receptive to political decisions under various regimes regarding two environmental policies: education policy and environmental tax policy. By doing so, we examined whether the presence of tax burdens affected the acceptability of political regimes, i.e., electoral democracy, lottocracy, and epistocracy. Our results revealed that decisions based on lottocracy and epistocracy were significantly less acceptable than those based on electoral democracy. Nevertheless, lottocratic and epistocratic decisions were more acceptable regarding the issue of environmental tax policy. The difference was mainly attributed to people's rejection of environmental tax policy offsetting their rejection of lottocracy and epistocracy. This suggests, first, that decisions based on electoral democracy increase policies' acceptability if they do not involve taxation, and second, that the status of whether or not a decision is electoral does not significantly affect policy acceptability if taxation is involved, whereas on the other hand, people are sensitive to differences between the regimes if the policy does not involve taxation.
Developing a Sitting Simple Baduanjin program for advanced cancer patients with the fatigue-sleep disturbance symptom cluster: A feasibility study
Authors: Zou Huina , Chen Liangying , Duan Tingjin , Lin Xiaoyan , Zheng Jianwei , Xiao Huimin 
Published: October 2024

AbstractObjectivesWe describe a development and feasibility study of a Sitting Simple Baduanjin program for advanced cancer patients suffering from the fatigue–sleep disturbance symptom cluster. This study was to evaluate the practicality and safety of the Sitting Simple Baduanjin intervention and determine its preliminary efficacy.MethodsThis work employed a single-arm mixed-methods approach. The primary outcome measures were feasibility (i.e., recruitment, adherence, and satisfaction) and safety. Validated self-report questionnaires were used to evaluate the preliminary effects of the program, including fatigue, sleep quality, and quality of life at the 4th, 8th, and 12th weeks of the intervention. Qualitative interviews were also conducted after the program.ResultsA total of 30 participants were enrolled, of which 23 (77%) completed the 12-week Sitting Simple Baduanjin program. The mean adherence rate was 88% and no adverse events were reported. Statistically significant improvements were observed in terms of fatigue, sleep quality, and quality of life after program completion. Four themes emerged from the qualitative interview data: (a) acceptability of the Sitting Simple Baduanjin technique, (b) perceived benefits of exercise, (c) barriers, and (d) facilitators.Significance of ResultsThe findings support the feasibility of the Sitting Simple Baduanjin program for advanced cancer patients and show promise in improving patients’ levels of the fatigue–sleep disturbance symptom cluster and quality of life.
Cover crop effects on the growth of perennial weeds in two long-term organic crop rotations
Authors: Melander Bo , Rasmussen Jim , Sørensen Peter 
Published: October 2024

Abstract
Cover crops are important in organic arable cropping systems because they improve soil fertility and suppress annual weeds in the post-harvest period (the period between cash crops), but their effectiveness against perennial weeds is less clear. This study analyzed outbreaks of perennial weeds in two long-term organic crop rotations with and without cover crops in the period 2011–2022 in Denmark. In addition, the impact of including forage plantain (Plantago lanceolata) in cover crop mixtures on the growth of perennial weeds was studied from 2020 to 2022. P. lanceolata is known to contain secondary metabolites that inhibit nitrification and may influence nitrogen (N) availability. This study found that cover crops did not hinder outbreaks of Cirsium arvense, Sonchus arvensis, Elytrigia repens or other perennial weed species. E. repens actually proliferated more with cover crops whose presence prevented repeated mechanical post-harvest interventions. The crop rotation involving regular cutting of a one-year or two-year green manure crop provided the best management of perennial weeds if repeated post-harvest soil cultivation was also conducted. This could only be done in the absence of cover crops. Mixing P. lanceolata into the cover crop mixtures did not change the outcome of competition between cover crops and perennial weeds in the period between crop harvest in August and November. Instead, P. lanceolata significantly reduced the number of shoots emerging from perennial weeds in the subsequent growing season. The causality of this effect was not further elaborated in the study.
Seeking balance: The role of Article 6(5) of Additional Protocol II in balancing justice and peace in transitions from armed conflict to peace
Authors: Acosta López Juana Inés 
Published: October 2024

Abstract
This article explores the role of Article 6(5) of Additional Protocol II to the Geneva Conventions in balancing justice and peace during transitions from armed conflict to peace. It argues that the provision, which encourages the granting of broad amnesties at the cessation of hostilities, requires a re-evaluation of the obligation to investigate, prosecute and punish under international law. By analyzing the legal context and scope of Article 6(5), as well as its application in transitional justice models such as in Colombia, the article highlights how the principle of peace can be prioritized alongside justice without undermining victims’ rights. The discussion critically addresses maximalist interpretations of justice, presenting a nuanced approach that foregrounds restorative justice and the importance of reconciliation in post-conflict societies.
“Si vis pacem, impera bellum”: The ICRC, international humanitarian law and peace
Authors: Palmieri Daniel 
Published: October 2024

Abstract
This article examines the links between the concept of peace and international humanitarian law (IHL). It takes a closer look at how the originator of IHL, the International Committee of the Red Cross, justified the existence of this body of law, which was supposed to regulate war, in the face of those who wanted to see war abolished once and for all. The article also questions the attitude of the International Red Cross and Red Crescent Movement, which, while wanting a peaceful society, did not give itself the means to achieve one.
Going Negative in Autocracy: A Field Experiment at the Moscow Mayoral Elections
Authors: Mironov Maxim , Petrachkova Alexandra 
Published: October 2024

AbstractOpposition in autocracies often uses negativism against the regime to frame its principal message. This study is the first to experimentally evaluate the effectiveness of a negative campaign on a regime candidate’s vote share. For the field experiment conducted during the 2013 Moscow mayoral election, we published a newspaper criticizing the incumbent mayor. We distributed approximately 130,000 copies near the entrances of 20 stations on four randomly selected metro lines one month prior to the election. We found that the incumbent’s vote share was 1.7 percentage points lower at the voting stations where the newspaper was distributed. These votes go to other candidates who address issues raised by the negative campaign. Anti-regime campaigning does not suppress turnout or increase disapproval voting.
Improvements to EXSIM in Ground Motion Simulation for Earthquakes Explained by Double‐Corner‐Frequency Source Model
Authors: Ma Wanjun , Xie Zhinan , Fu Lei , Shan Zhendong , Lu Jianqi , Tang Lihua , Zhang Xubin 
Published: October 2024

AbstractThe stochastic EXtended finite‐fault ground‐motion SIMulation algorithm (EXSIM) has been widely applied in simulating and predicting broadband strong ground‐motion. However, an increasingly number of researchers have found that EXSIM may overestimate ground‐motions at low frequencies for some large‐magnitude earthquakes and/or thrust earthquakes, for which the far‐field source model has been explained by a double‐corner‐frequency model. Despite controversy, the double‐corner‐frequency model is now being accepted as one of the main categories of the far‐field source model. This study demonstrated the limited applicability of EXSIM to earthquakes explained by the double‐corner‐frequency source model, by presenting the equivalence between motions generated by EXSIM and those generated by EXSIM's point‐source version, SMSIM, which adopts the ω‐square single‐corner‐frequency model. Furthermore, two improvements to EXSIM have been proposed: (a) the incorporation of the asperity‐distributed stress‐drop compound faults model and (b) the hybrid application of EXSIM with the proposed model. The effects of the two improvements have been verified by comparing EXSIM‐generating motions with recorded ground‐motions for the 2013 Mw 6.7 Lushan thrust earthquake. Significantly, consistent simulation accuracy has been achieved across high‐ and low‐frequency bands as well as in far‐ and near‐fields. The consistent accuracy of the improved EXSIM in simulating high‐ and low‐frequency ground motions enables its direct and independent application to broadband ground motion simulations. Moreover, the first validation of this consistent accuracy in both near‐ and far‐field scenarios further enhances its application in earthquake engineering practices.
Phytoplankton Spring Bloom Inhibited by Marine Heatwaves in the North‐Western Mediterranean Sea
Authors: Li Mengyu , Organelli Emanuele , Serva Federico , Bellacicco Marco , Landolfi Angela , Pisano Andrea , Marullo Salvatore , Shen Fang , Mignot Alexandre , van Gennip Simon , Santoleri Rosalia 
Published: October 2024

AbstractMarine heatwaves (MHWs) represent anomalously warm temperature conditions of seawater that may affect marine life and ocean biogeochemistry. Under such conditions, phytoplankton communities may modify their structure and functions, and their resilience is not assured. This study characterizes the impact of MHWs on the phytoplankton spring bloom in the North‐Western Mediterranean Sea. Here, we synergistically combine autonomous observations from BioGeoChemical‐Argo floats, satellite‐based and marine ecosystem model data, and show that MHW events occurring during winter drastically inhibit phytoplankton carbon biomass in spring by up to 70%. Such reduction is related to the enhanced stratification of the water column under MHWs which hinders the renewal of nutrients from deep‐ocean reservoirs, thus preventing surface phytoplankton from blooming. This process negatively impacts particulate organic carbon stocks within the mixed layer, while severe events cause an earlier shift of phytoplankton phenology that provokes changes in zooplankton biomass distribution.
Flow Evolution and Vertical Accelerations in Wave‐Swash Interactions
Authors: Meza‐Valle Claudio , Pujara Nimish 
Published: October 2024

AbstractWe report on a laboratory study of wave‐swash interactions, which occur in the very nearshore environment of a beach when the shallow swash flow of a breaking wave interacts with a subsequent wave. Wave‐swash interactions have been observed in the field, hypothesized to be important for nearshore transport processes, and categorized into different qualitative types, but quantitative descriptions of their dynamics have remained elusive. Using consecutive solitary waves with different wave heights and separations, we generate a wide variety of wave‐swash interactions with large flow velocities and vertical accelerations. We find that wave‐swash interactions can be quantitatively characterized in terms of two dimensionless parameters. The first of them corresponds to the wave height ratio for consecutive waves, and the second is a dimensionless measure of the time separation between consecutive wave crests. Using measurements of bed pressure and free‐surface displacement, we estimate the total vertical accelerations and focus on the peak upward‐directed acceleration. We find that wave‐swash interactions can generate vertical accelerations that can easily exceed gravity, despite occurring in very shallow water depths. The large vertical accelerations are upward‐directed and are quickly followed by onshore‐directed horizontal velocities. Together, our findings suggest that wave‐swash interactions are capable of inducing large material suspension events of sediment or solutes in sediment pores, and transporting them onshore. While the data are from a single location making it difficult to generalize the findings across the swash zone, the results clearly demonstrate the importance of large vertical accelerations in wave‐swash interactions.
Is neck pain a marker for something serious? Like myelopathy
Authors: Sial Alisha W. , Sima Stone , Narulla Rajpal , Najib Nashwa , Davies Mark , Diwan Ashish D. 
Published: October 2024

AbstractDegenerative Cervical Myelopathy (DCM) is a chronic progressive condition of the cervical spine that leads to compression of the spinal cord. It is the most common cause of spinal cord dysfunction in adults, and it occurs due to age-related changes or genetically associated pathologies. DCM is a clinical and radiological diagnosis and presents with a spectrum of symptoms ranging from neck pain and stiffness to paralysis. While neck pain is prevalent amongst patients attending specialist clinics, its predictive value for DCM is limited. This paper focuses on elucidating the relationship between DCM and chronic neck pain, and we discuss the underlying aetiology and broader neurological implications in the context of the literature. The progression of DCM can be slow and insidious with symptoms worsening gradually over time. Neck pain should not be discounted in the evaluation of DCM.
Association of plasma arachidonic acid levels with a bipolar disorder and the effects of a FADS gene variant
Authors: Ashizawa Takuma , Saito Takeo , Okochi Tomo , Ninomiya Kohei , Ito Kenta , Aoki Rei , Ikeda Masashi , Iwata Nakao 
Published: October 2024

AbstractRecent genome-wide association studies (GWASs) have identified fatty acid desaturase (FADS) genes, which code key enzymes involved in polyunsaturated fatty acid (PUFA) desaturation as susceptibility genes for bipolar disorder (BD). Several quantitative changes in PUFAs suggest their involvement in BD pathogenesis. Therefore, this study aimed to clarify the relationship between BD and PUFAs by conducting lipidomics covariating with the FADS gene variant (rs174550), which is associated with PUFA levels and BD susceptibility. The concentrations of 23 fatty acids were measured using plasma samples from the BD group (n = 535) and the control group (n = 107). Differences in each PUFA concentration ratio were compared between the two groups. Also, differences in each PUFA concentration ratio were compared for each genotype in rs174550. Our results showed that the BD group had significantly lower concentrations of linoleic acid (LA) (β = −0.36, p = 0.023) and arachidonic acid (AA) (β = −0.18, p = 0.013) than the control group. Concerning the effect of FADS on the PUFA concentration ratio, carriers of C-allele at rs174550 had significantly decreased γ-linolenic acid and AA concentration ratios. A previous GWAS reported that the presence of a C-allele at rs174550 increased the BD risk. This direction is consistent with the lipidomic results of the present study. In conclusion, both the FADS and BD were considered to regulate the AA concentration. Thus, as the FADS gene variant is crucial for conducting lipidomics of BD we believe that the allele frequency of FADS must be analyzed.
SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice
Authors: Wang Shuai , He Ting , Luo Ya , Ren Kexin , Shen Huanming , Hou Lingfeng , Wei Yixin , Fu Tong , Xie Wenlong , Wang Peng , Hu Jie , Zhu Yu , Huang Zhengrong , Li Qiyuan , Li Weihua , Guo Huiling , Li Boan 
Published: October 2024

AbstractBrown adipose tissue (BAT) is critical for non-shivering thermogenesis making it a promising therapeutic strategy to combat obesity and metabolic disease. However, the regulatory mechanisms underlying brown fat formation remain incompletely understood. Here, we found SOX4 is required for BAT development and thermogenic program. Depletion of SOX4 in BAT progenitors (Sox4-MKO) or brown adipocytes (Sox4-BKO) resulted in whitened BAT and hypothermia upon acute cold exposure. The reduced thermogenic capacity of Sox4-MKO mice increases their susceptibility to diet-induced obesity. Conversely, overexpression of SOX4 in BAT enhances thermogenesis counteracting diet-induced obesity. Mechanistically, SOX4 activates the transcription of EBF2, which determines brown fat fate. Moreover, phosphorylation of SOX4 at S235 by PKA facilitates its nuclear translocation and EBF2 transcription. Further, SOX4 cooperates with EBF2 to activate transcriptional programs governing thermogenic gene expression. These results demonstrate that SOX4 serves as an upstream regulator of EBF2, providing valuable insights into BAT development and thermogenic function maintenance.
GRHL2 regulates keratinocyte EMT-MET dynamics and scar formation during cutaneous wound healing
Authors: Chen Tianying , Zhang Bo , Xie Hanqi , Huang Chenyu , Wu Qiong 
Published: October 2024

AbstractAfter cutaneous wounds successfully heal, keratinocytes that underwent the epithelial-mesenchymal transition (EMT) regain their epithelial characteristics, while in scar tissue, epidermal cells persist in a mesenchymal state. However, the regulatory mechanisms governing this reversion are poorly understood, and the impact of persistent mesenchymal-like epidermal cells in scar tissue remains unclear. In the present study, we found that during wound healing, the regulatory factor GRHL2 is highly expressed in normal epidermal cells, downregulated in EMT epidermal cells, and upregulated again during the process of mesenchymal-epithelial transition (MET). We further demonstrated that interfering with GRHL2 expression in epidermal cells can effectively induce the EMT. Conversely, the overexpression of GRHL2 in EMT epidermal cells resulted in partial reversion of the EMT to an epithelial state. To investigate the effects of failed MET in epidermal cells on skin wound healing, we interfered with GRHL2 expression in epidermal cells surrounding the cutaneous wound. The results demonstrated that the persistence of epidermal cells in the mesenchymal state promoted fibrosis in scar tissue, manifested by increased thickness of scar tissue, deposition of collagen and fibronectin, as well as the activation of myofibroblasts. Furthermore, the miR-200s/Zeb1 axis was perturbed in GRHL2 knockdown keratinocytes, and transfection with miR-200s analogs promoted the reversion of EMT in epidermal cells, which indicates that they mediate the EMT process in keratinocytes. These results suggest that restoration of the epithelial state in epidermal cells following the EMT is essential to wound healing, providing potential therapeutic targets for preventing scar formation.
Unrecognised actionability for breast cancer risk variants identified in a national-level review of Australian familial cancer centres
Authors: Fortuno Cristina , Cops Elisa J. , Davidson Aimee L. , Hadler Johanna , Innella Giovanni , McKenzie Maddison E. , Parsons Michael , Campbell Ainsley M. , Dubowsky Andrew , Fargas Verna , Field Michael J. , Mar Fan Helen G. , Nichols Cassandra B. , Poplawski Nicola K. , Warwick Linda , Williams Rachel , Beshay Victoria , Edwards Caitlin , Johns Andrea , McPhillips Mary , Kumar Vanessa Siva , Scott Rodney , Williams Mark , Scott Hamish , James Paul A. , Spurdle Amanda B. 
Published: October 2024

AbstractBreast cancer remains a significant global health challenge. In Australia, the adoption of publicly-funded multigene panel testing for eligible cancer patients has increased accessibility to personalised care, yet has also highlighted the increasing prevalence of variants of uncertain significance (VUS), complicating clinical decision-making. This project aimed to explore the spectrum and actionability of breast cancer VUS in Australian familial cancer centers (FCCs). Leveraging data from 11 FCCs participating in the Inherited Cancer Connect database, we retrieved VUS results from 1472 patients. Through ClinVar crosschecks and application of gene-specific ACMG/AMP guidelines, we showed the potential for reclassification of 4% of unique VUS as pathogenic or likely pathogenic, and 80% as benign or likely benign. Surveys conducted with FCCs and diagnostic laboratories described current practices and challenges in variant reclassifications, highlighting resource constraints preventing periodic VUS review and notifications from the laboratories to the FCCs. Our study suggests there are benefits to routine VUS review and reclassification, particularly in publicly-funded healthcare systems. Future research should focus on assessing the clinical impact and cost-effectiveness of implementing routine variant review practices, alongside efforts to enhance communication between FCCs and laboratories.
Guided bone regeneration improves defect fill and reconstructive outcomes in 3-wall peri-implantitis defects
Authors: Afrashtehfar Kelvin I. , Alfallaj Hayam A. , Fernandez Eduardo , Hussaini Souheil 
Published: October 2024

Abstract
Design
This multi-center, randomized clinical trial compared the long-term outcomes of guided bone regeneration (GBR) with open flap debridement (OFD) in treating peri-implantitis-related bony defects with ≥3 osseous walls over 36 months. The study aimed to evaluate the healing potential of GBR using a deproteinized bovine bone mineral (DBBM) graft and native bilayer collagen membrane (NBCM) compared to OFD without the use of graft materials.

Case selection
Sixty-six individuals diagnosed with peri-implantitis were randomly assigned to either GBR (34 patients) or OFD (32 patients). The OFD group served as the control, where inflamed tissue was removed and the implant surface decontaminated using 3% hydrogen peroxide, but no bone graft was placed. The GBR group received DBBM and NBCM for defect reconstruction. Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP), suppuration (SUP), mucosal recession (MREC), and patient-reported outcomes (PROs) were assessed over the study duration. Post-surgical care included azithromycin, ibuprofen, and chlorhexidine rinses.

Study timeline
The study involved baseline assessments, surgical interventions, and follow-ups at 6, 12, and 36 months. Supportive peri-implant therapy was provided every 3 months during the additional 24-month follow-up.

Data analysis
Primary outcome was RDF at 36 months. Secondary outcomes included PPD, BOP, SUP, MREC, and PROs. Descriptive statistics and ANCOVA models were used for analysis.

Results
At 36 months, GBR resulted in a mean RDF of 2.13  ±  1.26 mm, compared to 1.64  ±  1.54 mm with OFD (p  =  .18). No significant differences were found in PPD, BOP, SUP, REC, or PROs between the groups. Treatment success (defined as no additional bone loss, PPD ≤ 5 mm, no BOP, and no SUP) was achieved in 46.2% of GBR cases and 20% of OFD cases (p = 0.053).

Conclusions
GBR provided improved short-term defect fill and higher treatment success compared to OFD, although the differences were not statistically significant. Both procedures maintained clinical parameters over 36 months, with similar patient satisfaction (PROs) observed for GBR and OFD. The adjunct use of DBBM and NBCM may offer clinical benefits for peri-implantitis cases with specific bony defect morphology.