bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica
Authors: Ruiz-Campillo Maria Teresa , Molina Hernandez Veronica , Escamilla Alejandro , Stevenson Michael , Perez Jose , Martinez-Moreno Alvaro , Donnelly Sheila , Dalton John P. , Cwiklinski Krystyna 
Published: May 2017

AbstractImmune signatures of sheep acutely-infected withFasciola hepatica, an important pathogen of livestock and humans were analysed within the peritoneal compartment to investigate early infection. Within the peritoneum,F. hepaticaantibodies coincided with an intense innate and adaptive cellular immune response, with infiltrating leukocytes and a marked eosinophilia (49%). However, while cytokine qPCR analysis revealed IL-10, IL-12, IL-13, IL-23 and TGFβ were elevated, these were not statistically different at 18 days post-infection compared to uninfected animals indicating that the immune response is muted and not yet skewed to a Th2 type response that is associated with chronic disease. Proteomic analysis of the peritoneal fluid identified infection-related proteins, including several structural proteins derived from the liver extracellular matrix, connective tissue and epithelium, and proteins related to the immune system. Periostin and vascular cell adhesion protein 1 (VCAM-1), molecules that mediate leukocyte infiltration and are associated with inflammatory disorders involving marked eosinophilia (e.g. asthma), were particularly elevated in the peritoneum. Immuno-histochemical studies indicated that the source of periostin and VCAM-1 was the inflamed sheep liver tissue. This study has revealed previously unknown aspects of the immunology and pathogenesis associated with acute fascioliasis in the peritoneum and liver.
PCDH18 is frequently inactivated by promoter methylation in colorectal cancer
Authors: Zhou Dan , Tang Weiwei , Su Guoqiang , Cai Mingquan , An Han-Xiang , Zhang Yun 
Published: May 2017

AbstractProtocadherin18 (PCDH18) was found to be preferentially methylated and inactivated in colorectal cancer (CRC) using bioinformatics tools. However, its biologic role in tumorgenesis remains unclear. Herein, we aimed to elucidate its epigenetic regulation and biological functions in CRC. The methylation status of PCDH18 was significant higher in CRC tissues than in adjacent non-tumor tissues (median, 15.17% vs. median, 0.4438%). Expression level of PCDH18 was significantly lower in primary CRCs than in nonmalignant tissues. Importantly, methylation status of PCDH18 in cell-free DNA of CRC patients was also significantly higher than in healthy subjects. PCDH18 was readily expressed in NCM460 cells, but downregulated in 100% (4/4) of CRC cell lines by promoter methylation, despite its expression could be restored through demethylation treatment. Overexpression of PCDH18 suppressed CRC cell viability, colony formation and migration. Meanwhile, the depletion of PCDH18 by siRNA in NCM460 cells enhanced the colonogenicity and migration ability and promoted β-catenin nuclear accumulation, whereas it inhibited cell cycle arrest. These effects were associated with upregulation of phospho-GSK-3β and cyclin D1, and downregulation of caspase3 and p21. Our results suggested that PCDH18 was a putative tumor suppressor with epigenetic silencing in CRC and a potential biomarker for CRC diagnosis.
Antennal and abdominal transcriptomes reveal chemosensory gene families in the coconut hispine beetle, Brontispa longissima
Authors: Bin Shu-Ying , Qu Meng-Qiu , Li Ke-Ming , Peng Zheng-Qiang , Wu Zhong-Zhen , Lin Jin-Tian 
Published: May 2017

AbstractAntennal and abdominal transcriptomes of males and females of the coconut hispine beetle Brontispa longissima were sequenced to identify and compare the expression patterns of genes involved in odorant reception and detection. Representative proteins from the chemosensory gene families likely essential for insect olfaction were identified. These include 48 odorant receptors (ORs), 19 ionotropic receptors (IRs), 4 sensory neuron membrane proteins (SNMPs), 34 odorant binding proteins (OBPs) and 16 chemosensory proteins (CSPs). Phylogenetic analysis revealed the evolutionary relationship of these proteins with homologs from Coleopterans or other insects, and led to the identification of putative aggregation pheromone receptors in B. longissima. Comparative expression analysis performed by calculating FPKM values were also validated using quantitative real time-PCR (qPCR). The results revealed that all ORs and antennal IRs, two IR co-receptors (BlonIR8a and BlonIR25a) and one SNMP (BlonSNMP1a) were predominantly expressed in antennae when compared to abdomens, and approximately half of the OBPs (19) and CSPs (7) were enriched in antennae. These findings for the first time reveal the identification of key molecular components in B. longissima olfaction and provide a valuable resource for future functional analyses of olfaction, and identification of potential targets to control this quarantine pest.
RiceAtlas, a spatial database of global rice calendars and production
Authors: Laborte Alice G. , Gutierrez Mary Anne , Balanza Jane Girly , Saito Kazuki , Zwart Sander J. , Boschetti Mirco , Murty M.V.R. , Villano Lorena , Aunario Jorrel Khalil , Reinke Russell , Koo Jawoo , Hijmans Robert J. , Nelson Andrew 
Published: May 2017

AbstractKnowing where, when, and how much rice is planted and harvested is crucial information for understanding the effects of policy, trade, and global and technological change on food security. We developed RiceAtlas, a spatial database on the seasonal distribution of the world’s rice production. It consists of data on rice planting and harvesting dates by growing season and estimates of monthly production for all rice-producing countries. Sources used for planting and harvesting dates include global and regional databases, national publications, online reports, and expert knowledge. Monthly production data were estimated based on annual or seasonal production statistics, and planting and harvesting dates. RiceAtlas has 2,725 spatial units. Compared with available global crop calendars, RiceAtlas is nearly ten times more spatially detailed and has nearly seven times more spatial units, with at least two seasons of calendar data, making RiceAtlas the most comprehensive and detailed spatial database on rice calendar and production.
Time and Speed of Vascular Pedicle Dissection in Deep Inferior Epigastric Artery Perforator Flap Elevation
Authors: Yim Ji , Lee Yeon , Kim Young , Kim Eun , Lee Taik , Yun Jiyoung , Eom Jin 
Published: May 2017

Background Breast reconstruction using deep inferior epigastric artery perforator (DIEP) free flap is widely used because of the advantages of minimizing donor-site morbidity, but it requires technical competency in vascular dissection. This study evaluated the influence of patient factors and vascular status on the time and speed of dissection of the vascular pedicle.
Methods DIEP free flap procedures were performed in 49 patients assigned to immediate or delayed reconstruction groups. Factors that significantly influenced the time required and the speed of dissection were evaluated.
Results The average total dissection time was 55.9 minutes (34.5 minutes for the intramuscular dissection and 21.4 minutes for the submuscular dissection). The dissection speed for the total vascular pedicle was 2.65 cm/10 minutes (1.71 cm/10 minutes for the intramuscular dissection and 4.30 cm/10 minutes for the submuscular dissection). The presence of a Pfannenstiel scar, length of the vascular pedicle in the intramuscular area, and the number of microclips used significantly correlated with the total dissection time.
Conclusion The length of the intramuscular pedicle, number of microclips used, and presence of a Pfannenstiel scar significantly correlated with the total dissection time of the vascular pedicle. An assessment prior to the surgery can reduce the time of operation and make it easier to elevate the flap.
Belastung mit Freizeitlärm unter jungen Erwachsenen: Ergebnisse des ersten Follow-Up der Ohrkan-Kohortenstudie
Authors: Gerstner Doris , Twardella Dorothee , Reiter Christina , Weilnhammer Veronika , Kolb Stefanie , Herr Caroline 
Published: May 2017

Zusammenfassung
Ziel Analyse von Änderungen in der Freizeitlärmexposition von Jugendlichen im Verlauf von 2,5 Jahren.
Methoden Die Daten stammen aus der Kohortenstudie Ohrkan. Hierfür wurden 2 149 Jugendliche (größtenteils 15–16 Jahre alt) der 9. Jahrgangstufe von 2009–2011 in Regensburg rekrutiert (O-I). Das erste Follow-up (O-II) fand 2,5 Jahre später statt. In O-I und O-II wurden Fragebogendaten zur Betätigungsdauer mit lärmintensiven Freizeitaktivitäten und Literaturangaben zu dabei zu erwartenden durchschnittlichen Schallpegeln genutzt, um die Gesamtlärmexposition in der Freizeit zu schätzen. Diese wurde mittels Beurteilungspegeln aus dem Arbeitsschutz (unterer Auslösewert/uAW von 80dB(A)) bewertet. Faktoren, die eine Freizeitlärmexposition über 80dB(A) beeinflussen, wurden mittels logistischer Regressionsmodelle untersucht.
Ergebnisse Für 1 704 Teilnehmenden (54% weiblich) lagen Daten zu beiden Zeitpunkten vor. Die Freizeitlärmexposition war in beiden Erhebungsrunden sehr hoch: 75% der Teilnehmenden überstiegen den uAW in O-I, 92% in O-II. Die Zunahme der Lärmexposition ist besonders auf häufigere Diskothekenbesuche zurückzuführen. Die Nutzung von tragbaren Musikabspielgeräten (PLD) sank leicht um 2%, war aber zu beiden Zeitpunkten die Aktivität mit der häufigsten Nennung und der längsten Einwirkdauer. In O-II war ein Beenden der Schulausbildung mit einer hohen Lärmexposition durch PLD assoziiert, während ein höheres Alter mit einer hohen Lärmexposition durch Diskothekenbesuche verbunden war.
Schlussfolgerung Die Ohrkan-Studie zeigt, dass Jugendliche und junge Erwachsene im Freizeitbereich durch unterschiedliche Quellen einer sehr hohen Lärmexposition ausgesetzt sind und dass sich die Hauptquellen der Exposition mit dem Alter ändern. Dieses Wissen sollte für die Entwicklung von Präventionsmaßnahmen genutzt werden, um die Exposition mit Freizeitlärm gezielt zu senken.
Bedeutung von Arbeitsbelastungen bei Rehabilitanden – Anwendung eines Index für Berufstätigkeiten
Authors: Brünger Martin , Spyra Karla 
Published: May 2017

Zusammenfassung
Ziel der Studie Es soll die Bedeutung von Arbeitsbelastungen bei Rehabilitanden untersucht werden.
Methodik Es wurde eine Sekundärdatenanalyse einer Untersuchung von 2089 Rehabilitanden der Deutschen Rentenversicherung Bund durchgeführt. Arbeitsbelastung wurde mithilfe des Index nach Kroll anhand der beruflichen Tätigkeit operationalisiert.
Ergebnisse Die Prävalenz hoher Berufstätigkeits-spezifischer Arbeitsbelastung lag bei 11,2%. Es zeigte sich ein signifikanter Zusammenhang zu Reha-relevanten Beeinträchtigungen und zu einer ungünstigen sozialmedizinischen Prognose am Reha-Ende auch unabhängig vom Vorliegen selbstberichteter besonderer beruflicher Problemlagen.
Schlussfolgerung Der Arbeitsbelastungsindex kann Berufstätigkeits-spezifische Arbeitsbelastungen bei Rehabilitanden abbilden. Er bietet aufgrund seiner Konstruktion über die gängigen Berufsklassifikationen breite Einsatzmöglichkeiten bei Nutzung und Verknüpfung von Routinedaten.
High Leptin Level Attenuates Embryo Development in Overweight/Obese Infertile Women by Inhibiting Proliferation and Promotes Apoptosis in Granule Cell
Authors: Lin Xian-hua , Wang Hui , Wu Dan-dan , Ullah Kamran , Yu Tian-tian , Ur Rahman Tanzil , Huang He-feng 
Published: May 2017

AbstractObesity appears to be associated with female reproductive dysfunction and infertility. Women with obesity undergoing in vitro fertilization (IVF) had poor oocyte quality, decreased embryo development, and poor pregnancy outcome. However, the mechanism linking obesity to poor reproductive outcomes is still unclear. Obesity is frequently accompanied with elevated leptin levels. Here we aimed to evaluate the effect of high leptin level in follicular fluid (FF) on the proliferation and apoptosis in granule cells and correlate these findings with poor reproductive outcomes in infertile women with overweight or obesity who underwent IVF treatment. We investigated clinical and ongoing pregnancy rates in 189 infertile women who underwent IVF. Leptin levels were quantified in peripheral blood and FF as well. In vitro cell model was used to explore the potential effect of high leptin on the proliferation and apoptosis in granulosa cells. Results showed reduced clinical and ongoing pregnancy rates in overweight/obesity women who underwent IVF compared to control with normal BMI. On the other hand, leptin levels presented significant increase in peripheral blood and FF in overweight/obese women. Leptin level in FF was negatively correlated to good quality embryo rate. Importantly, in vitro study showed that leptin inhibited cells proliferation and promoted apoptosis by upregulation of caspase-3 and downregulation of Bcl-2 in granulosa cells in a dose dependent manner. These observations suggest that leptin may acts as a local mediator to attenuate embryo development and reduce fertility in obese patients.
Die Arbeitszufriedenheit von Berufseinsteigern in den Gesundheitsberufen
Authors: Ulrich Gert , Homberg Angelika , Karstens Sven , Goetz Katja , Mahler Cornelia 
Published: May 2017

Zusammenfassung
Einleitung Ziel der vorliegenden Befragung war es, die Arbeitszufriedenheit von Berufseinsteigern in ausgewählten Gesundheitsberufen zu erfassen und determinierende Faktoren der Arbeitszufriedenheit zu identifizieren.
Methoden Es wurden insgesamt 579 Absolventen aus den Berufsgruppen Pflege (P; Altenpflege, Gesundheits- und Krankenpflege, Gesundheits- und Kinderkrankenpflege; n=368), Therapie (T; Physiotherapie, Logopädie; n=102) und Diagnostik (D; Medizinisch-technische Laboratoriums Assistenz, Medizinisch-technische Radiologie Assistenz; n=109) ca. ein Jahr nach Ausbildungsabschluss zu einem Online-Survey eingeladen. Die Arbeitszufriedenheit wurde mittels des Warr-Cook-Wall (WCW) Fragebogens, bestehend aus 10 Fragen, bestimmt. Neben der deskriptiven Analyse wurde eine lineare Regression zur Bestimmung der Einflussfaktoren auf die Arbeitszufriedenheit durchgeführt.
Ergebnisse Ausgewertet wurden die Daten von 189 Berufseinsteigern (P: 121, T: 32, D: 36; männlich: 19%; Rücklaufquote: 32,6%). Die Gesamtzufriedenheit mit dem Arbeitsplatz aller Berufseinsteiger betrug 4,9±1,6 (MW±SD) und war bei den T (5,4±1,4) gegenüber den P (4,7±1,6) und den D (5,0±1,5) leicht erhöht. Besonders positiv wurde von allen Berufsgruppen die Zufriedenheit mit Kollegen und Mitarbeitern beurteilt. Eine geringere Zufriedenheit fand sich über die Berufsgruppen hinweg bei der Variable „Einkommen“. Die Variable der Zufriedenheit mit „Kollegen und Mitarbeitern“ zeigte in der linearen Regression die höchste Assoziation mit der Gesamtzufriedenheit mit dem Arbeitsplatz.
Schlussfolgerung Die einzelnen Variablen des WCW-Fragebogens deuten auf gute bis sehr gute Zufriedenheitswerte der von uns befragten Berufseinsteiger hin. Kollegen stellen die wichtigste Quelle für die eigene Arbeitszufriedenheit dar. Vor dem Hintergrund des sich abzeichnenden Fachkräftemangels liefern die Ergebnisse einen wichtigen Beitrag, um die Arbeitszufriedenheit zu erhalten und somit die Versorgungsqualität zu sichern.
Treatment with Mountain-Cultivated Ginseng Alleviates Trimethyltin-Induced Cognitive Impairments in Mice via IL-6-Dependent JAK2/STAT3/ERK Signaling
Authors: Tu Thu-Hien Thi , Sharma Naveen , Shin Eun-Joo , Tran Hai-Quyen , Lee Yu Jeung , Nah Seung-Yeol , Tran Hoang-Yen Phi , Jeong Ji Hoon , Jeong Jung Hwan , Ko Sung Kwon , Byun Jae Kyung , Kim Hyoung-Chun 
Published: May 2017

Abstract
Panax ginseng is the most widely used herbal medicine for improving cognitive functions. The pharmacological activity and underlying mechanisms of mountain-cultivated ginseng, however, have yet to be clearly elucidated, in particular, against trimethyltin-induced cognitive dysfunction. We previously reported that interleukin-6 plays a protective role against trimethyltin-induced cognitive dysfunction. Because of this, we have implemented a study system that uses interleukin-6 null (−/−) and wild-type mice. Interestingly, mountain-cultivated ginseng significantly upregulated interleukin-6 expression. With this study, we sought to determine whether the interleukin-6-dependent modulation of the Janus kinase 2/signal transducer activator of transcription 3 and extracellular signal-regulated kinase signaling network is also associated with the pharmacological activity of mountain-cultivated ginseng against trimethyltin-induced cognitive dysfunction. Trimethyltin treatment (2.4 mg/kg, intraperitoneal) causes the downregulation of Janus kinase 2/signal transducer activator of transcription 3, extracellular signal-regulated kinase signaling, and impairment of the cholinergic system. We found that mountain-cultivated ginseng treatment (50 mg/kg, intraperitoneal) significantly attenuated cognitive impairment normally induced by trimethyltin by upregulating p-Janus kinase 2/signal transducer activator of transcription 3, p-extracellular signal-regulated kinase signaling, and the cholinergic system. Trimethyltin-induced cognitive impairments were more pronounced in interleukin-6 (−/−) mice than wild-type mice, and they were markedly reduced by treatment with either mountain-cultivated ginseng or recombinant interleukin-6 protein (6 ng, intracerebroventricular). Additionally, treatment with either AG490 (20 mg/kg, intraperitoneal), a Janus kinase 2/signal transducer activator of transcription 3 inhibitor, or U0126 (2 µg/head, intracerebroventricular), an extracellular signal-regulated kinase inhibitor, reversed the effects of mountain-cultivated ginseng treatment. The effects of mountain-cultivated ginseng treatment were comparable to those of recombinant interleukin-6 protein in interleukin-6 (−/−) mice. Our results, therefore, suggest that mountain-cultivated ginseng acts through interleukin-6-dependent activation of Janus kinase 2/signal transducer activator of transcription 3/extracellular signal-regulated kinase signaling in order to reverse cognitive impairment caused by trimethyltin treatment.
Can Amphibians Help Conserve Native Fishes?
Authors: Clancy Niall G. 
Published: May 2017

Abstract
Native fish populations have continued to decline worldwide despite advances in management practices. As such, new approaches are needed to complement the old. In many flowing and standing waters, larval amphibians are the dominant vertebrate taxa. This can be important to fisheries due to amphibians’ ability to influence macroinvertebrate communities, alter benthic habitat, and supply nutrients in aquatic systems. These changes can, in turn, affect the ecology and fitness of other aquatic organisms such as fishes. Due to their large effects in some systems, it is suggested that fisheries managers carefully consider actions that may affect amphibian populations and actively conserve them in some cases. Preservation of riparian areas and amphibian-associated microhabitats may even be used as a tool to positively impact freshwater fisheries by conserving amphibians that help maintain aquatic systems. Therefore, knowledge of local amphibian life histories and behaviors may be important in conserving associated freshwater fisheries.
Aquatic Biodiversity in the U.S. State Wildlife Action Plans
Authors: Mawdsley Jonathan , Palmeri Davia , Humpert Mark 
Published: May 2017

Abstract
We surveyed state wildlife action plan (SWAP) coordinators in all 50 U.S. states; the commonwealths of Puerto Rico and the Northern Mariana Islands; the territories of the U.S. Virgin Islands, Guam, and America Samoa; and the District of Columbia to document the inclusion of aquatic animal species in the revised SWAPS, completed by state fish and wildlife agencies in 2015–2017. Based on the responses received, we anticipate increased coverage of several major aquatic groups, including fishes, dragonflies and damselflies, mollusks, crayfishes, and corals, in the revised plan documents. A majority of SWAPs will include key aquatic groups such as native freshwater fishes, freshwater snails, freshwater mussels, dragonflies and damselflies, crayfishes, stoneflies, and mayflies. By incorporating these species into the revised plans, state fish and wildlife agencies and their partners will have opportunities to apply dedicated funding from programs such as the State and Tribal Wildlife Grants Program to the conservation of these species and their habitats.
Responsible Recreational Fisheries: A Chinese Perspective
Authors: Yang Zi-jiang , Chen Yushun , Wang Dongchun , Liu Long-teng , Liu Cong , Hughes Robert M. , Liu Yadan 
Published: May 2017

Abstract
Recreational fisheries have been largely developed only in recent decades in China. However, this development is not occurring in an entirely responsible manner. Responsible recreational fisheries in China require fully considering socioeconomic and environmental impacts and minimizing negative impacts of fisheries and fishery products. Responsible recreational fisheries also need to consider climate change, responsible tourism, and developing a modern fishery. In this paper, we define the concept of responsible recreational fisheries, present its current status and challenges, and then provide strategies and recommendations. We conclude that both recreational anglers and fishery enterprises should practice self-discipline, be aware of local community needs, follow fisheries laws and regulations, and respect local cultures. It is urgent for fisheries governmental agencies in China to generate policies and regulations to ensure the development of its recreational fisheries in a responsible manner.
‘Le blanc souci de notre toile’: Writing White in Modern French Poetry and Art
Authors: Robertson Eric 
Published: May 2017

Abstract
White has the value of an optical sensation that exceeds colour: it is the condition of light, the sum total of all the colours of the spectrum combined. While it can therefore signify totality, it is also synonymous with the unfinished, the colour of the blank canvas, and the empty page. Perhaps on account of this ambivalent status, at once stopping short of and transcending perceptible phenomena, white has the power to evoke a more spiritual realm that might lie beyond the three dimensions of the material world. Unsurprisingly, then, white holds an iconic status in the development of abstract art and modern poetry alike. Examining a range of instances from Mallarmé to Malevich, Apollinaire to Arp, Didi-Huberman’s reflections on the work of Simon Hantaï, Sarkis, and Esther Shalev-Gerz, and the intermedial poetry of Caroline Bergvall, this reading of colour will explore some of the different significations that white has acquired in poetry and art-writing.
Colour, Desire, and Destruction in Béatrice Bonhomme’s
La Maison abandonnée
Authors: O’Connor Clémence 
Published: May 2017

Abstract

To write colour is to draw into the space of the text an element of the visual idiom that resists words: while a painting’s line and framing invite the viewer of even non-figurative art to perceive semantically, colour expressivity defies language. Yet its immediacy and embodiment appeal to the contemporary poet. In Béatrice Bonhomme’s
livre d’artiste
,
La Maison abandonnée
(2006), a collaboration with pastel artist Christine Charles, we follow the speaker’s meanderings through a house soon to be destroyed, but ephemerally painted over by a fresco or graffiti artist who remains anonymous. Colour saturates the speaker’s apprehension of the place and is presented as a catalyst to the act of writing; yet it ultimately eludes words, which prove unable to tell colour apart from light or from other senses, namely touch. But, in their discontinuous, gradually undone account of the viewing process, words can still bring out the congruity of colour’s temporality and aesthetics. Violent, chaotic, and desire-driven, the frescoes seem to look forward to their destruction, presenting it as a creative process in its own right; one that will intensify their celebratory energy and their hurried, unbridled aesthetics in a moment of consummate undoing.