bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual ovarian stimulation and random start in assisted reproductive technologies: from ovarian biology to clinical application
Authors: Vaiarelli Alberto , Venturella Roberta , Vizziello Damiano , Bulletti Francesco , Ubaldi Filippo M. 
Published: March 2017

Purpose of review
The opportunity to use gonadotropins to stimulate the growth of antral follicles coming from different follicular waves available in different moment of the menstrual cycle allowed the implementation of innovative protocols in assisted reproductive technologies. The purpose of this review is to explore the possible advantages related to these new controlled ovarian stimulation (COS) strategies.

Recent findings
Women exhibit major and minor wave patterns of ovarian follicular development during the menstrual cycle, as it is in animal species. These observations led to the introduction of two new strategies for COS: the random start and the double ovarian stimulation within a single menstrual cycle.

Summary
The use of gonadotropin-releasing hormone antagonist COS protocols, started randomly at any day of the menstrual cycle, is today a standard procedure in those cases where obtaining oocytes is an urgent task, such as in case of fertility preservation for malignant diseases or other medical indications.
On the other hand, in poor prognosis patients, double ovarian stimulation has been suggested with the aim of maximizing the number of oocytes retrieved within a single menstrual cycle and, in turn increasing the chance to obtain a reproductively competent embryo. Randomized control trials are necessary to confirm these preliminary findings.
27-GAUGE VITRECTOMY WOUND INTEGRITY
Authors: Khan M. Ali , Durrani Alia K. , Hsu Jason , Regillo Carl D. 
Published: March 2017

Purpose:
To compare clinical outcomes using angled versus straight trocar insertion during 27-gauge pars plana vitrectomy for epiretinal membrane.

Methods:
Pilot randomized controlled trial. Thirty eyes of 30 patients undergoing 27-gauge pars plana vitrectomy with membrane peeling for epiretinal membrane were randomized 1:1 to receive angled or straight trocar insertion. Intraocular pressure (IOP) and postoperative wound-related complications were compared.

Results:
Fifteen eyes were randomized to each the angled and straight incision groups. No significant difference in phakic status (P = 0.71) or preoperative IOP (15.1 ± 3.4 vs. 14.6 ± 3.0 mmHg, P = 0.67) existed between groups. On postoperative Day 1, eyes in the straight group had lower IOP compared with the angled group (11.8 ± 3.9 vs. 15.3 ± 5.2 mmHg, P = 0.04) and a relative decrease in IOP compared with preoperative values (11.8 ± 3.9 vs. 15.1 ± 3.4 mmHg, P < 0.01). No IOP difference between groups was present at Day 7 (P = 0.43) or Day 30 (P = 0.42). Postoperative complications included transient hypotony (1 eye, straight group) and serous choroidal detachment (1 eye, angled group).

Conclusion:
Eyes with straight incisions had transiently lower IOP on postoperative Day 1, possibly suggestive of subclinical wound leak in the very early postoperative period. Overall, rates of hypotony and sclerotomy-related complications were similarly low between wound construction strategies.
Impact of Ophthalmic Surgeon Experience on Early Postoperative Central Corneal Thickness After Cataract Surgery
Authors: Lhuillier Louis , Jeancolas Anne L. , Renaudin Laurie , Goetz Christophe , Ameloot François , Premy Shanour , Ouamara Nadia , Perone Jean M. 
Published: March 2017

Purpose:
To assess the impact of surgeon experience on early postoperative central corneal thickness (CCT) in eyes that have undergone phacoemulsification-based cataract surgery.

Methods:
One hundred sixty eyes underwent phacoemulsification-based cataract surgery performed by an experienced surgeon (n = 110; senior group) or a surgically less experienced ophthalmic assistant (n = 50; junior group), using the divide-and-conquer or tilt-and-tumble technique for cataractous lens extraction. The primary endpoint was postoperative corneal edema 2 hours after surgery, determined by pachymetry-based CCT.

Results:
Mean age of patients was 71.5 ± 9.1 years. Mean CCT at postoperative hour 2 was 622.8 ± 69.3 μm: an increase of 14.3% ± 10.8 from 545.3 ± 33.7 μm preoperatively (P = 0.0028). Mean CCT at postoperative hour 2 and postoperative corneal edema were significantly higher for the junior group than the senior group, with mean respective increases of 105.8 ± 81.4 μm (19.3% ± 14.2%) and 66.4 ± 3.7 μm (12.3% ± 8.3%), P = 0.0001. After adjustment for confounding factors, surgical experience was the only factor significantly associated with corneal edema: β = 39.58; SD = 11.05; P = 0.0005. Other intergroup differences observed included significantly longer mean operating and mean ultrasound times in the junior group than in the senior group. A final corneal suture was used more frequently in the senior than in the junior group, at rates of 32.7% and 2.0%, respectively, P < 0.0001.

Conclusions:
Greater surgical experience was found to be associated with reduced early postoperative corneal edema, shorter operative time, and shorter ultrasound time. This suggests that beyond mastering the initial learning curve of phacoemulsification, surgical experience enables faster and safer surgery.
Anxiety Associated With High‐resolution Anorectal Manometry in Pediatric Patients and Parents
Authors: Lamparyk Katherine , Mahajan Lori , Debeljak Ashley , Steffen Rita 
Published: March 2017

ABSTRACTHigh‐resolution anorectal manometry is an increasingly common procedure performed in pediatric patients to rule out Hirschsprung and assess anorectal function and sensation. The purpose of the present study was to evaluate anxiety of patients and their parents associated with high‐resolution anorectal manometry. Preprocedural anxiety was assessed by standardized questionnaire in all parents and children older than 8 years and observed behavioral distress was recorded by the attending pediatric gastroenterologist. Thirty‐five children (mean age = 7.2 years, ±2.8) and their parents completed the study. Patient anxiety was found to be markedly elevated. Observed behavioral distress was elevated compared to more invasive procedures. Self‐reported parental anxiety was comparable to adults undergoing endoscopic procedures themselves. Despite the low risk of this procedure, healthcare providers should be aware of the high levels of anxiety and distress that occur in patients and their parents associated with anorectal manometry.
Placental transfer of antibody and its relationship to vaccination in pregnancy
Authors: Calvert Anna , Jones Christine E. 
Published: March 2017

Purpose of review
Vaccination in pregnancy boosts maternal vaccine-specific antibody concentration and therefore increases transplacental transfer of antibody to optimize protection of the infant. The purpose of this review is to describe what is known about placental transfer of antibody in the context of vaccination in pregnancy, focussing on the recent literature and areas of debate, particularly about the timing of vaccination.

Recent findings
There is a debate about the timing of pertussis vaccination in pregnancy with some studies reporting that vaccination in the third trimester results in higher pertussis antigen-specific IgG concentrations in cord blood and others finding that the concentration is higher following vaccination in the second trimester. The impact of timing of vaccination on antibody avidity in cord blood has also been investigated and one study suggests that avidity may be increased following vaccination at 27–30+6 gestational weeks compared with later vaccination.

Summary
Understanding placental transfer of antibody is vital in informing maternal vaccination strategy. There has been recent research about the timing of pertussis vaccination in pregnancy that has implications for the timing of both current and future vaccines to be used in pregnancy.
EXPLANe: An Extensible Framework for Poster Annotation with Mobile Devices
Authors: Gopal Nikhil , Su Andrew , Wu Chunlei , Mooney Sean D. 
Published: March 2017

AbstractSummaryScientific posters tend to be brief, unstructured, and generally unsuitable for communication beyond a poster session. This paper describes EXPLANe, a framework for annotating posters using optical text recognition and web services on mobile devices. EXPLANe is demonstrated through an interface to the MyVariant.info variant annotation web services, and provides users a list of biological information linked with genetic variants (as found via extracted RSIDs from annotated posters). This paper delineates the architecture of the application, and includes results of a five-part evaluation we conducted. Researchers and developers can use the existing codebase as a foundation from which to generate their own annotation tabs when analyzing and annotating posters.AvailabilityAlpha EXPLANe software is available as an open source application athttps://github.com/ngopal/EXPLANeContactSean D. Mooney (sdmooney@uw.edu)
Understanding neural circuit development through theory and models
Authors: Richter Leonidas M. A. , Gjorgjieva Julijana 
Published: March 2017

AbstractHow are neural circuits organized and tuned to achieve stable function and produce robust behavior? The organization process begins early in development and involves a diversity of mechanisms unique to this period. We summarize recent progress in theoretical neuroscience that has substantially contributed to our understanding of development at the single neuron, synaptic and network level. We go beyond classical models of topographic map formation, and focus on the generation of complex spatiotemporal activity patterns, their role in refinements of particular circuit features, and the emergence of functional computations. Aided by the development of novel quantitative methods for data analysis, theoretical and computational models have enabled us to test the adequacy of specific assumptions, explain experimental data and propose testable hypotheses. With the accumulation of larger data sets, theory and models will likely play an even more important role in understanding the development of neural circuits.
Modeling the dynamics of progression of chromosomal alterations in cervical cancer: a computational model
Authors: Cabrera-Becerril Augusto , Vargas-De-León Cruz , Hernández Sergio , Miramontes Pedro , Peralta Raúl 
Published: March 2017

AbstractComputational modeling has been applied to simulate the heterogeneity of cancer behavior. The development of Cervical Cancer (CC) is a process in which the cell acquires dynamic behavior among non-deleterious and deleterious mutations, exhibiting chromosomal alterations as a manifestation of this dynamic. To further determine the progression of chromosomal alterations in precursor lesions and CC, we introduce a computational model to study the dynamic of deleterious and non-deleterious mutations as an outcome of tumor progression. Analysis of chromosomal alterations mediated by our model reveals that multiple deleterious mutations are more frequent in precursor lesions than in CC. Cells with lethal deleterious mutations would be eliminated, which would mitigate cancer progression; on the other hand, cells with non-deleterious mutations would become dominant, which could predispose to cancer progression. The study of somatic alterations by computer simulations during cancer progression provides a feasible pathway for insights into the transformation of cell mechanisms in humans. During cancer progression, tumors may acquire new phenotype traits, such as the ability to invade and metastasize or to become clinically important when they develop drug resistance. Chromosomal alterations non deleterious contributes to this progression.
Iterative model-based density improvement yields better atomic structures from cryo-EM maps
Authors: Jakobi Arjen J. , Wilmanns Matthias , Sachse Carsten 
Published: March 2017

AbstractAtomic models based on high-resolution density maps are the ultimate result of the cryo-EM structure determination process. Current cryo-EM model refinement procedures work with the experimental density map that remains constant throughout the process. Here, we introduce a general procedure that iteratively improves cryo-EM density maps based on prior knowledge of an atomic reference structure. The procedure optimizes contrast of cryo-EM densities by local amplitude scaling (LocScale) based on an atomic model without introducing model bias. We alternate the procedure with consecutive rounds of model refinement and tested it on four cryo-EM structures of TRPV1, β-galactosidase, γ-secretase and RNA polymerase III. We demonstrate that LocScale density improvement reveals previously undiscovered map features and improves the quality of atomic models. The presented approach enhances the interpretability of cryo-EM density maps and provides an implementation reminiscent of iterative density improvement as it is routinely employed in the refinement of X-ray crystallographic models.
Epithelial-mesenchymal plasticity: How have quantitative mathematical models helped improve our understanding?
Authors: Jolly Mohit Kumar , Tripathi Satyendra C , Somarelli Jason A , Hanash Samir M , Levine Herbert 
Published: March 2017

AbstractPhenotypic plasticity, the ability of cells to reversibly alter their phenotypes in response to signals, presents a significant clinical challenge to treating solid tumors. Tumor cells utilize phenotypic plasticity to evade therapies, metastasize, and colonize distant organs. As a result, phenotypic plasticity can accelerate tumor progression. A well-studied example of phenotypic plasticity is the bidirectional conversions among epithelial, mesenchymal, and hybrid epithelial/mesenchymal phenotype(s). These conversions can alter a repertoire of cellular traits associated with multiple hallmarks of cancer, such as metabolism, immune-evasion, and invasion and metastasis. To tackle the complexity and heterogeneity of these transitions, mathematical models have been developed that seek to capture the experimentally-verified molecular mechanisms and act as ‘ hypothesis-generating machines’. Here, we discuss how these quantitative mathematical models have helped us explain existing experimental data, guided further experiments, and provided an improved conceptual framework for understanding how multiple intracellular and extracellular signals can drive epithelial-mesenchymal plasticity at both the single-cell and population levels. We also discuss the implications of this plasticity in driving multiple aggressive facets of tumor progression.
Genetic costs of domestication and improvement
Authors: Moyers Brook T. , Morrell Peter L. , McKay John K. 
Published: March 2017

ABSTRACTThe ‘cost of domestication’ hypothesis posits that the process of domesticating wild species can result in an increase in the number, frequency, and/or proportion of deleterious genetic variants that are fixed or segregating in the genomes of domesticated species. This cost may limit the efficacy of selection and thus reduce genetic gains in breeding programs for these species. Understanding when and how deleterious mutations accumulate can also provide insight into fundamental questions about the interplay of demography and selection. Here we describe the evolutionary processes that may contribute to deleterious variation accrued during domestication and improvement, and review the available evidence for ‘the cost of domestication’ in animal and plant genomes. We identify gaps and explore opportunities in this emerging field, and finally offer suggestions for researchers and breeders interested in understanding or avoiding the consequences of an increased number or frequency of deleterious variants in domesticated species.
Family business internationalisation and networks: emerging pathways
Authors: Kampouri Katerina , Plakoyiannaki Emmanuella , Leppäaho Tanja 
Published: March 2017

PurposeThe aim of this study is twofold: to provide a meta-synthesis of the current state of knowledge in family business (FB) internationalisation research, adopting a network perspective, and to highlight emerging themes that may set the stage for future work on FB internationalisation, for the benefit of researchers adopting a network perspective.Design/methodology/approachTo address the twofold purpose of the study, the current paper provides a state-of-the-art review of 25 peer-reviewed journal articles published from 1993 to 2014. This study also presents a meta-synthesis of the theoretical approaches, key findings and concepts that were pinpointed in the review, and proposes emerging key themes that are likely to set the stage for future work within this specific field.FindingsThe results indicated that since the mid-1990s, research in the field from a network perspective has mainly focused on three aspects, namely, the role of networks and relationships in the internationalisation process, the factors that influence network formation and strategic/managerial issues in the formation and building of network ties. The current paper pinpoints emerging themes within these three aspects and proposes future pathways.Research limitations/implicationsThe review and meta-synthesis are restricted to 25 studies identified in this specific field.Originality/valueThis study comprises an initial attempt to encompass the interface of FB internationalisation and networks.
Herbert Simon’s bounded rationality
Authors: Cristofaro Matteo 
Published: March 2017

PurposeThe purpose of this paper is to investigate the historical advancements attained on the bounded rationality concept in management research, considering the key influencing discoveries in related fields. Understanding the cross-fertilization that has occurred is the first step to go beyond the current knowledge on bounded rationality and to face its challenges.Design/methodology/approachThe adopted method is historical. This research approach helps to explain the evolution of a widespread concept in a scientific field and, particularly, to identify the parallel influencing advancements made in related domains.FindingsInvestigation of the irrational forces of human reasoning is at the centre of today’s research agenda on rationality in organizations, claiming to be an extension of the original bounded rationality concept. In this regard, scholars should commit themselves to build a more holistic approach to the investigation of human rationality, conjointly applying socio-biological and behavioural perspectives to explain the real behaviour of people in organizations and society. This reconnection will also help to overcome the inner limits of some “fashion of the month” streams that have yet to demonstrate their contribution.Originality/valueThis is the first study that offers an overall historical evolution of the bounded rationality concept which considers both management research and developments in related fields. The historically educed lessons learned are at the basis of the concluding recommendations for future research.
Analyzing Lean Six Sigma enablers: a hybrid ISM-fuzzy MICMAC approach
Authors: Yadav Gunjan , Desai Tushar N. 
Published: March 2017

Purpose
The purpose of this paper is to identify Lean Six Sigma enablers (LSSEs) and analyse the interaction among the enablers via a hierarchical model developed by employing interpretive structural modelling (ISM) and determine the driving and dependence power of enablers through fuzzy MICMAC (Matriced’ Impacts Croise´s Multiplication Applique´ea´un Classement) analysis.

Design/methodology/approach
An expert group of industry professionals and academicians is consulted at the initial stage as an input for ISM methodology to explore the paired relationship among LSSEs for each parameter of Lean Six Sigma (LSS) implementation. The outcome of ISM is further utilized by fuzzy MICMAC analysis to discover the enablers that are strong drivers and highly dependent. Fuzzy set is included in MICMAC analysis in order to obtain more precise output and effective model.

Findings
In total, 20 key enablers are identified through a literature review and expert opinion that emerged as the most significant factors towards LSS implementation. The identified enablers are portrayed into a structural form representing as input and output variables. Later, the driving and the dependence power of each enabler is presented in cluster form.

Research limitations/implications
The paired relationships among LSSEs are obtained through the interpretation made by the experts. The judgments of experts are subjective and may be biased; as difference in expert opinion may influence the final outcome. Conducting a large-scale survey may provide a better catch for interactions of LSSEs.

Practical implications
This study provides strong practical implications for researchers as well as industry practitioners. The industry professionals must deliberately focus on the identified LSSEs more conservatively during LSS implementation and the top management should plan strategically to avoid any implementation failure.

Originality/value
The present study identifies 20 crucial enablers of integrated LSS and presents them in a hierarchical form which will be beneficial for researchers and practitioners. The interactions among the enablers shown in cluster form will help in better execution of LSS.
Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria
Authors: Muthusamy Saraladevi , Lundin Daniel , Mamede Branca Rui Miguel , Baltar Federico , González José M. , Lehtiö Janne , Pinhassi Jarone 
Published: March 2017

SummaryMuch of the phenotype of a microorganism consists of its repertoire of metabolisms and how and when its proteins are deployed under different growth conditions. Hence, analyses of protein expression could provide important understanding of how bacteria adapt to different environmental settings. To characterize the flexibility of proteomes of marine bacteria, we investigated protein profiles of three important marine bacterial lineages – Oceanospirillaceae (Neptuniibacter caesariensis strain MED92), Roseobacter (Phaeobacter sp. MED193) and Flavobacteria (Dokdonia sp. MED134) – during transition from exponential to stationary phase. As much as 59–80% of each species’ total proteome was expressed. Moreover, all three bacteria profoundly altered their expressed proteomes during growth phase transition, from a dominance of proteins involved in translation to more diverse proteomes, with a striking appearance of enzymes involved in different nutrient‐scavenging metabolisms. Whereas the three bacteria shared several overarching metabolic strategies, they differed in important details, including distinct expression patterns of membrane transporters and proteins in carbon and phosphorous metabolism and storage compounds. These differences can be seen as signature metabolisms – metabolisms specific for lineages. These findings suggest that quantitative proteomics can inform about the divergent ecological strategies of marine bacteria in adapting to changes in environmental conditions.
Pseudococcus orchidicola(Hemiptera: Pseudococcidae), a newly found mealybug pest, confused withP. longispinusin Korea
Authors: Koo Hyun‐Na , Kim Seulki , Lee Jae Seon , Kang Won Jin , Cho Woo Seong , Kyung YeJin , Seo Jin‐Won , Kim HyunKyung , Kim Gil‐Hah , Cho Soowon 
Published: March 2017

AbstractPseudococcus longispinus, a notorious cosmopolitan pest species of mealybugs, known to be distributed indoors in Korea since 2002, is found to be mixed with another species,Pseudococcus orchidicola. FindingP. orchidicolaas a pest of tropical plants in Korea is rather unexpected because of their main distribution in the Pacific area and South Asia. However, all the available information from morphology, molecule and advice on identification from mealybug specialists indicates this is the best match forP. orchidicola. Morphological, molecular and some biological notes onP. orchidicolaare provided with some adult and nymphal images, and compared withP. longispinus. A full discussion mainly on identity and distribution ofP. orchidicolais given.