bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized Correlation Coefficient for Non-Parametric Analysis of Microarray Time-Course Data
Authors: Tan Qihua , Thomassen Mads , Burton Mark , Mose Kristian Fredløv , Andersen Klaus Ejner , Hjelmborg Jacob , Kruse Torben 
Published: July 2017

AbstractModeling complex time-course patterns is a challenging issue in microarray study due to complex gene expression patterns in response to the time-course experiment. We introduce the generalized correlation coefficient and propose a combinatory approach for detecting, testing and clustering the heterogeneous time-course gene expression patterns. Application of the method identified nonlinear time-course patterns in high agreement with parametric analysis. We conclude that the non-parametric nature in the generalized correlation analysis could be an useful and efficient tool for analyzing microarray time-course data and for exploring the complex relationships in the omics data for studying their association with disease and health.
Health-related quality of life among children with Turner syndrome: controlled cross-sectional study
Authors: Amedro Pascal , Tahhan Nabil , Bertet Helena , Jeandel Claire , Guillaumont Sophie , Mura Thibault , Picot Marie-Christine 
Published: July 2017

AbstractBackground:The aim of the study was to assess health-related quality of life (HR-QoL) in children with Turner syndrome in comparison with controls.Methods:We prospectively recruited 16 female girls with Turner syndrome (mean age 15.2±2.6 years) and 78 female controls (mean age 12.7±2.8 years) in randomly selected schools. We used the PedsQL, a generic HR-QoL questionnaire (self and parents’ versions).Results:Global HR-QoL scores in Turner syndrome were lower than controls for self-reports (respectively, 74.3±3.0 vs. 82.8±1.3, p=0.01) and parents’ reports (62.7±3.8 vs. 80.1±1.7, p<0.0001). In Turner syndrome, self-reported HR-QoL was impaired in school functioning (70.6±4.0 vs. 80.71±1.7, p=0.02), social functioning (78.2±4.0 vs. 90.4±1.8, p<0.01) and physical functioning (78.5±3.2 vs. 87.1±1.4, p=0.02), but not in emotional functioning. Parents’ reported HR-QoL was impaired in all four dimensions.Conclusions:HR-QoL was impaired in this cohort of young females with Turner syndrome, as in previously reported adult studies. In addition to medical treatment and routine clinical follow-up, female girls and teenagers with Turner syndrome should also be supported psychologically by social, educational and psychotherapeutic interventions that aim to address their self-esteem and emotional difficulties.
Impact of Repatriate’s Knowledge Transfer on Enterprise Performance: The Mediating Effect of Ambidexterity Innovation
Authors: Wang Juanru , Li Baolin 
Published: July 2017

AbstractThis paper proposes that repatriate’s knowledge transfer is composed of two dimensions: Explicit knowledge transfer and tacit knowledge transfer. The influencing of repatriate’s knowledge transfer on enterprise performance is discussed, and the mediating role of ambidexterity innovation in the above relationships is analyzed. Then, relative assumptions are put forward, and theoretical model is established. Lastly, 156 multinational corporations are selected as study object, and data are collected, bias analysis, descriptive statistic analysis and hierarchical regression analysis are made. The conclusions are got, which are explicit knowledge transfer and tacit knowledge transfer have significant positive effect on exploitative innovation and exploratory innovation, respectively; and explicit knowledge transfer has more effect on exploitative innovation, while tacit knowledge transfer has more effect on exploratory innovation. The findings also indicate that exploitative innovation and exploratory innovation play partial mediation effect on the relationship between explicit knowledge transfer, tacit knowledge transfer and enterprise performance.
Czech Armed Forces and Some Aspects of Helicopters Acquisition
Authors: Novotný Antonín , Procházka Dalibor 
Published: July 2017

Abstract
After several years of discussion and decision-making approaches Army of the Czech Republic to implement the purchase of multipurpose helicopters to replace the previously used, morally and physically obsolete attack helicopters Mi-24 / 34. The process of acquisition consists of many stages; it is not a simple matter and has its pitfalls. It is also a big, expensive and long-term acquisition in which the poor implementation can cause problems that are likely to affect the Army of the Czech Republic and its Air Force for many years. One of the decision-making process inputs is an estimate of Life Cycle Cost (LCC). For the estimation, many methods can be used. The paper deals with application of system dynamics to LCC estimation process. Partial models of utilization and support Life Cycle phases are presented, which can be further developed according to consecutive data availability. An influence of different helicopter operating modes on a Life Cycle Cost is demonstrated by means of simulation in Vensim application. The models, after verification and validation, can be used to support the acquisition process.
Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications and future prospects
Authors: Ganorkar Saurabh B. , Shirkhedkar Atul A. 
Published: July 2017

AbstractThis review presents the essential brief annals, crucial analytics, precise applications and noteworthy implications of design of experiments which enrouted to liquid chromatography (LC) in the midst of utmost focus on high-performance liquid-chromatography (HPLC) and broadened its impressions on allied techniques in pharmaceutical analysis. Being most widely applied statistical methodologies for such purpose, its use was started in 1970 and heightened after Fischer’s precious input in 1981. The persistent use of statistical approaches one after another led to the efficient attention of pharmaceutical analysts. Hence, in order to fine-tune the trail impressed by the cumulative trends, the use of statistical designs in HPLC analysis has been reviewed and efforts were made to recognize its relative impact and corresponding future prospects. Applications of precise methodologies have been reassessed with respect to the need established by recent regulatory perspectives with a fanatical and the consequent stance on prominent historical advancements and concrete purposes. An effort was also made to state an arbitrary classification of diverse design types and succinct line of application in LC and associated analyses.
„Ich spreche, also bin ich“
Authors: Novotný Pavel 
Published: July 2017

Summary
The subject of this paper is to deal with the specifics of Ladislav Novák’s sound poetry succinctly, thus to create some important starting points for further possible literary or interdisciplinary research. Firstly, completely unknown, privately recorded compositions of Novák are investigated, secondly his professionally created audiotape-works that are relatively well known, however with little attention from the literary science, will be discussed.
Mechanical and Durability Properties of Fly Ash Based Concrete Exposed to Marine Environment
Authors: Kagadgar Sarfaraz Ahmed , Saha Suman , Rajasekaran C. 
Published: July 2017

Abstract
Efforts over the past few years for improving the performance of concrete suggest that cement replacement with mineral admixtures can enhance the strength and durability of concrete. Feasibility of producing good quality concrete by using alccofine and fly ash replacements is investigated and also the potential benefits from their incorporation were looked into. In this study, an attempt has been made to assess the performance of concrete in severe marine conditions exposed upto a period of 150 days. This work investigates the influence of alccofine and fly ash as partial replacement of cement in various percentages (Alccofine - 5% replacement to cement content) and (fly ash - 0%, 15%, 30%, 50% & 60% to total cementitious content) on mechanical and durability properties (Permit ion permeability test and corrosion current density) of concrete. Usage of alccofine and high quantity of fly ash as additional cementitious materials in concrete has resulted in higher workability of concrete. Inclusion of alccofine shows an early strength gaining property whereas fly ash results in gaining strength at later stage. Concrete mixes containing 5% alccofine with 15% fly ash replacement reported greater compressive strength than the other concrete mixes cured in both curing conditions. Durability test conducted at 56 and 150 days indicated that concrete containing higher percentages of fly ash resulted in lower permeability as well lesser corrosion density.
Estimating Traffic Accidents in Turkey Using Differential Evolution Algorithm
Authors: Akgüngör Ali Payıdar , Korkmaz Ersin 
Published: July 2017

Abstract
Estimating traffic accidents play a vital role to apply road safety procedures. This study proposes Differential Evolution Algorithm (DEA) models to estimate the number of accidents in Turkey. In the model development, population (P) and the number of vehicles (N) are selected as model parameters. Three model forms, linear, exponential and semi-quadratic models, are developed using DEA with the data covering from 2000 to 2014. Developed models are statistically compared to select the best fit model. The results of the DE models show that the linear model form is suitable to estimate the number of accidents. The statistics of this form is better than other forms in terms of performance criteria which are the Mean Absolute Percentage Errors (MAPE) and the Root Mean Square Errors (RMSE). To investigate the performance of linear DE model for future estimations, a ten-year period from 2015 to 2024 is considered. The results obtained from future estimations reveal the suitability of DE method for road safety applications.
Evaluation of the Low Temperature Properties of Asphalt Mixtures Using a Digital Image Correlation Approach
Authors: Hill B. , Buttlar W. G. 
Published: July 2017

Abstract
Asphalt concrete performance hinges on its cracking resistance. Numerous test methods have been used to consider fracture of asphalt concrete at intermediate and low temperatures. All focus on global mixture measurements of load and displacement at a discrete location on the test specimen. Digital image correlation (DIC) measurements provide a means to evaluate the full-field response of asphalt concrete undergoing fracture. In particular, several studies have employed DIC to quantify the size of strain localization as a potential definition of the fracture process zone (FPZ). The current study evaluated the low temperature fracture properties of asphalt concrete using the disk-shaped compact tension (DC(T)) test (ASTM D7313-13) and in-plane DIC-measured FPZ size. Tests were completed to compare the sizes of the FPZ with respect to the test specimen thickness, aging of neat and polymer-modified asphalt mixtures, maximum aggregate size, and reclaimed asphalt pavement (RAP) content. Results in the current study found that DIC measurements differentiated the size of the FPZ in terms of polymer modification, aging, and RAP content.
Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria
Authors: Huang Hong Ming , Bauer Denis C , Lelliott Patrick M , Dixon Matthew W A , Tilley Leann , McMorran Brendan J , Foote Simon J , Burgio Gaetan 
Published: July 2017

Abstract
Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the intricate host–parasite interactions during malaria infections. In this study, we described a gene encoding erythrocytic ankyrin-1 (Ank-1) which exhibits allelic-dependent heterogeneous phenotypes during malaria infections. We conducted an ENU mutagenesis screen on mice and identified two Ank-1 mutations, one resulting in an amino acid substitution (MRI95845), and the other a truncated Ank-1 protein (MRI96570). Both mutations caused hereditary spherocytosis-like phenotypes and confer differing protection against Plasmodium chabaudi infections. Upon further examination, the Ank-1(MRI96570) mutation was found to inhibit intraerythrocytic parasite maturation, whereas Ank-1(MRI95845) caused increased bystander erythrocyte clearance during infection. This is the first description of allelic heterogeneity in ankyrin-1 from the direct comparison between two Ank-1 mutations. Despite the lack of direct evidence from population studies, this data further supported the protective roles of ankyrin-1 mutations in conferring malaria protection. This study also emphasized the importance of such phenomena in achieving a better understanding of host–parasite interactions, which could be the basis of future studies.
TheCaenorhabditis elegansFemale-Like State: Decoupling the Transcriptomic Effects of Aging and Sperm Status
Authors: Angeles-Albores David , Leighton Daniel H W , Tsou Tiffany , Khaw Tiffany H , Antoshechkin Igor , Sternberg Paul W 
Published: July 2017

AbstractUnderstanding genome and gene function in a whole organism requires us to fully comprehend the life cycle and the physiology of the organism in question. Caenorhabditis elegans XX animals are hermaphrodites that exhaust their sperm after 3 d of egg-laying. Even though C. elegans can live for many days after cessation of egg-laying, the molecular physiology of this state has not been as intensely studied as other parts of the life cycle, despite documented changes in behavior and metabolism. To study the effects of sperm depletion and aging of C. elegans during the first 6 d of adulthood, we measured the transcriptomes of first-day adult hermaphrodites and sixth-day sperm-depleted adults, and, at the same time points, mutant fog-2(lf) worms that have a feminized germline phenotype. We found that we could separate the effects of biological aging from sperm depletion. For a large subset of genes, young adult fog-2(lf) animals had the same gene expression changes as sperm-depleted sixth-day wild-type hermaphrodites, and these genes did not change expression when fog-2(lf) females reached the sixth day of adulthood. Taken together, this indicates that changing sperm status causes a change in the internal state of the worm, which we call the female-like state. Our data provide a high-quality picture of the changes that happen in global gene expression throughout the period of early aging in the worm.
Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions
Authors: Gray Vanessa E , Hause Ronald J , Fowler Douglas M 
Published: July 2017

Abstract
Mutagenesis is a widely used method for identifying protein positions that are important for function or ligand binding. Advances in high-throughput DNA sequencing and mutagenesis techniques have enabled measurement of the effects of nearly all possible amino acid substitutions in many proteins. The resulting large-scale mutagenesis data sets offer a unique opportunity to draw general conclusions about the effects of different amino acid substitutions. Thus, we analyzed 34,373 mutations in 14 proteins whose effects were measured using large-scale mutagenesis approaches. Methionine was the most tolerated substitution, while proline was the least tolerated. We found that several substitutions, including histidine and asparagine, best recapitulated the effects of other substitutions, even when the identity of the wild-type amino acid was considered. The effects of histidine and asparagine substitutions also correlated best with the effects of other substitutions in different structural contexts. Furthermore, highly disruptive substitutions like aspartic and glutamic acid had the most discriminatory power for detecting ligand interface positions. Our work highlights the utility of large-scale mutagenesis data, and our conclusions can help guide future single substitution mutational scans.
Dzietność a aktywność zawodowa kobiet w Polsce i innych krajach Unii Europejskiej w latach 2004–2014
Authors: Rękas Magdalena 
Published: July 2017

The “new demography of Europe” is characterised by consolidation of the recovery process of generations below the generational replacement level (a pronounced decline in fertility rates to low levels), a longer human life span and increased professional activity among women. The new demography has been affected to a great extent by the current economic policies of EU countries, as well as the problems they have had providing for future growth and economic development. The aim of this article is to present and analyse the relationship between fertility and women’s professional participation in Poland and other EU countries in the period 2004–2014. The article contains a review of theories addressing the impact of having a child on the professional activity of women and an analysis of data from Eurostat statistics using simple statistical methods and Pearson’s correlation coefficient. The results of the report Bilans kapitału ludzkiego w Polsce (The Study of Human Capital in Poland, 2015) show the influence of the number of children on the economic activity of women. As a result of the study, it is indicated that in the vast majority of EU countries, the employment rate for women is strongly linked to fertility levels. In Poland’s case, moreover, the number of children a woman has is a key factor in her economic activity – the higher the number of children, the lower her economic activity will be.
Soil hydraulic functions of international soils measured with the Extended Evaporation Method (EEM) and the HYPROP device
Authors: Schindler Uwe Georg , Müller Lothar 
Published: July 2017

Abstract. The paper presents a data base of 173 soil hydrological data (raw data) from 71 sites all over the world (Asia, Africa, Australia America and Europe). The samples were mainly collected and measured as part of research projects. The soils cover a wide range of texture classes and dry bulk densities. The data base consists of water retention and unsaturated hydraulic conductivity data. Additional data of the particle size distribution, the dry bulk density, the organic matter content and other variables are included. The hydraulic data were measured with the Extended Evaporation Method (EEM) and the HYPROP device in the range between saturation and close to the wilting point. Information to the geo reference, the soil type, the sampling depth and the horizon are given. Data access via DOI 10.4228/ZALF.2003.273.
Prevalence of dry eye syndrome in patients with non-insulin dependent diabetes: in urban South Indian population
Authors: Banu Shaheen , H. M. Ismail , B. Punam , S. Lalitha 
Published: July 2017

<p class="abstract"><strong><span lang="EN-US">Background:</span></strong>The study was performed to assess the prevalence of dry eye syndrome in patients with non-insulin dependent diabetes in urban south Indian population.</p><p class="abstract"><strong><span lang="EN-US">Methods:</span></strong>100 patients with non-insulin dependent diabetes in urban South Indian population were consecutively studied who attended OPD at Ideal Diabetes Care Center. Dry eyes were on the basis of history of ocular discomfort, including soreness, gritty sensation, itchiness, redness, blurred vision that improves with blinking and excessive tearing. The condition was confirmed by ocular surface dye staining pattern with fluorescein, tear film break up time (TBUT) and Schirmer test. All the patients were given artificial tears (carboxy methycellulose sodium eye drops).</p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong>Of 100 diabetic patients, 60 patients (60.0%) had dry eye syndrome. Dry eye syndrome was more common in older and female patients. A significant association was observed between duration of diabetes and frequency of dry eye syndrome. Of 60 patients with dry eye syndrome 43.0% suffered from gritty sensation, 41.0% had soreness. 26.0% complained from tearing, redness and 11.0% from pain. 60.0% had shimmer test positive. 8.0% had TBUT positive and none of the patients had abnormal corneal sensitivity test positive. Response after using artificial tears was good. </p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong><span lang="EN-US"> Our finding strongly support diabetic patients have an elevated prevalence </span>of dry eye syndrome. In this study the prevalence of dry eye syndrome was 60.0%. So, examination for dry eye should be an integral part of the assessment of dry eye disease. Further results showed management with artificial tears improved dry eye symptoms<span lang="EN-US">.</span></p>
Profile of seekers of an internet-based self-help program for depression in India: observations and implications
Authors: Mehrotra Seema , Sudhir Paulomi M. , C. R. Satish Kumar , Thirthalli Jagadisha , Rao Girish N. , Srikanth T. K. , Gandotra Aditi 
Published: July 2017

Background: Growing awareness of treatment gap for common mental health problems has provided an impetus to development of a variety of mental health apps. However there is a dearth of literature on potential users of such apps in India. Information of this nature can be vital in efforts at further development and dissemination of such apps for enhancing their public health impact. Methods: The paper focuses on examining the profile of individuals who expressed an interest in a newly developed internet based self-help program, called PUSH-D (Practice and Use Self-Help for depression). The PUSH-D pilot-trial was announced on various platforms and participation was solicited from individuals in the community. All those who communicated an interest were requested to participate in an initial evaluation session. Hundred and two individuals completed the evaluation that involved use of interviews and standardized questionnaires to assess depression severity, well-being, and functional impairment. Results: An average PUSH-D seeker was likely to be a young adult, with at least undergraduate level of education and was equally likely to be a male or a female. PUSH-D seekers were likely to have major depression or dysthymia; with mild to moderate severity of symptoms and significant impairment in functioning. Co-morbidities were evident only in a minority of PUSH-D seekers. Conclusions: About two third of PUSH-D seekers had never sought mental health services. Various barriers to seeking face to face professional consultations were reported. The results highlight the potential role of internet- based self-help programs for addressing treatment gap in India.