bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Impact of Unmanned Aerial System Observations on Numerical Weather Prediction in the Coastal Zone
Authors: Flagg David D. , Doyle James D. , Holt Teddy R. , Tyndall Daniel P. , Amerault Clark M. , Geiszler Daniel , Haack Tracy , Moskaitis Jonathan R. , Nachamkin Jason , Eleuterio Daniel P. 
Published: October 2017

Abstract
The Trident Warrior observational field campaign conducted off the U.S. mid-Atlantic coast in July 2013 included the deployment of an unmanned aerial system (UAS) with several payloads on board for atmospheric and oceanic observation. These UAS observations, spanning seven flights over 5 days in the lowest 1550 m above mean sea level, were assimilated into a three-dimensional variational data assimilation (DA) system [the Naval Research Laboratory Atmospheric Variational Data Assimilation System (NAVDAS)] used to generate analyses for a numerical weather prediction model [the Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS)] with a coupled ocean model [the Naval Research Laboratory Navy Coastal Ocean Model (NCOM)]. The impact of the assimilated UAS observations on short-term atmospheric prediction performance is evaluated and quantified. Observations collected from 50 radiosonde launches during the campaign adjacent to the UAS flight paths serve as model forecast verification. Experiments reveal a substantial reduction of model bias in forecast temperature and moisture profiles consistently throughout the campaign period due to the assimilation of UAS observations. The model error reduction is most substantial in the vicinity of the inversion at the top of the model-estimated boundary layer. Investigations reveal a consistent improvement to prediction of the vertical position, strength, and depth of the boundary layer inversion. The relative impact of UAS observations is explored further with experiments of systematic denial of data streams from the NAVDAS DA system and removal of individual measurement sources on the UAS platform.
Cancer Chemotherapy Update: Bevacizumab, Etoposide, and Cisplatin Regimen for Refractory Brain Metastases
Authors: Mayer Seth A. , Solimando Dominic A. , Waddell J. Aubrey 
Published: October 2017

The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc, 4201 Wilson Blvd #110-545, Arlington, VA 22203, email: OncRxSvc@comcast.net ; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, email: waddfour@charter.net . Regimen Name: Bevacizumab, etoposide, and cisplatin (BEEP) Origin of Name: The regimen is named for the medications it contains: bevacizumab, etoposide, and cisplatin.
How to Initiate Dementia Care Networks? Processes, Barriers, and Facilitators During the Development Process of a Practice-Oriented Website Toolkit Out of Research Results
Authors: Heinrich Steffen , Sommerfeld Ulrike , Michalowsky Bernhard , Hoffmann Wolfgang , Thyrian Jochen René , Wolf-Ostermann Karin , Roes Martina 
Published: October 2017

Background: Despite its high relevance, scientific evidence often fails to be disseminated into practice. Information websites can be a successful information dissemination tool, but very little is known about the processes involved in the interdisciplinary development of such websites. This article aims to demonstrate the processes, barriers, and facilitators during the development and publication of a practice-friendly information website grounded in scientifically based research findings about dementia care networks obtained by the DemNet-D study. Method: The qualitative data of this article are based on a work progress protocol and a recorded interview with the project’s science journalist. The interview was transcribed, analyzed, and coded based on structured content analysis. Quantitative data were extracted to display the website usage rate. Results: The results indicate that interdisciplinary teamwork is an essential factor for successful website development. Furthermore, the use of a formalized model can help to organize the development structure. To transform scientific content, a specialized expert in the field is needed. Continuous evaluations and marketing strategies are vital for the success of a website. The final website had a high access rate 1 month after launch. Conclusion: Crucial processes, barriers, and facilitators during the development of a practice-related information website about dementia care networks are presented and discussed. These findings can help people who aim to disseminate research findings to other practitioner-associated priority groups as well as public health-related groups.
Screening of Chronic Alcoholics for Cognitive Impairment Using Montreal Cognitive Assessment—Occupational Therapy Perspective
Authors: Sawant Parag , Gokhale Preetee , Ferzandi Zarine 
Published: October 2017

Rationale: Chronic alcoholics suffer from cognitive impairment, thereby affecting their ADL and work performance. Objectives: The objective was to screen chronic alcoholics for cognitive impairment and assessing affectations in various components of MoCA. Early screening to help them from further deterioration in ADL and work. Materials and Methodology: In this case control study, 50 chronic alcoholics, males, age group 30–50 years, abstaining for more than two months, referred to outpatient De-addiction Occupational Therapy department of K. E. M. Hospital, Mumbai were screened using MoCA (Hindi) and compared with their age matched control group. Results: All patients showed mild cognitive impairment (MCI) on MoCA, irrespective of pattern and frequency of drinking. Their average mean score in MoCA test and control group was 21.02 and 26.03, respectively. The domains more affected were language, abstraction and memory, thus affecting their performance in ADL and work. Results were analyzed using unpaired ‘ t’-test and were statistically significant at the level of p < 0.05 and 95 per cent confidence level. Conclusion: Screening of chronic alcoholics using MoCA showed MCI with varying degree of affectations in the sub-components of the test.
A solution-focused approach to understanding patient motivation in diabetes self-management: Gender differences and implications for primary care
Authors: Bhaloo Tajudaullah , Juma Michael , Criscuolo-Higgins Christine 
Published: October 2017

Objective Healthcare providers often neglect to recognize the role they play in motivating patients with diabetes to perform self-management. Our aims were to understand what motivates patients with diabetes to implement recommended self-management practices and understand the role of the primary care team in patient motivation. Methods We use a solution-focused qualitative approach, supplemented with a quantitative scale. We used a purposive sampling strategy to invite patients with uncontrolled diabetes. Semi-structured telephone interviews were conducted and analyzed using content and thematic analysis. Results Key motivators were strong support systems that included family and friends, the physician’s communication style and message, fear of deterioration, and other intrinsic factors. Female family members were described as supportive; not all married women felt supported by their husbands. Women were more influenced by empathy and concern from their doctor, compared to men who were motivated by improved health literacy. Women with few family or friends were more disadvantaged, regardless of race/ethnicity. Discussion While physicians play a vital role in motivating their patients, female patients may depend on this empathy more than males. The interdisciplinary care team can play an important role in helping patients create a support network where it may not exist.
‘Missed’ oesophageal adenocarcinoma and high‐grade dysplasia in Barrett's oesophagus patients: A large population‐based study
Authors: van Putten Margreet , Johnston Brian T , Murray Liam J , Gavin Anna T , McManus Damian T , Bhat Shivaram , Turkington Richard C , Coleman Helen G 
Published: October 2017

BackgroundA systematic review suggests that 25% of oesophageal adenocarcinomas (OAC) are ‘missed’ at index endoscopy for Barrett's oesophagus (BO); however, this included few population‐based studies and may be an overestimate.ObjectiveThe objective of this article is to quantify the ‘missed’ rates of high‐grade dysplasia (HGD) and OAC at index BO endoscopy.MethodsPatients from the Northern Ireland BO register diagnosed between 1993 and 2010 (n = 13,159) were linked to the Northern Ireland Cancer Registry to identify patients who developed OAC or HGD. Logistic regression analysis compared characteristics of ‘missed’ vs ‘incident’ HGD/OAC, defined as diagnoses within 3–12 months vs >1 year after incident BO, respectively.ResultsA total of 267 patients were diagnosed with HGD/OAC ≥3 months after BO diagnosis, of whom 34 (12.7%) were potentially ‘missed’. The proportion of ‘missed’ HGD/OAC was 25% among BO patients with low‐grade dysplasia (LGD) and 9% among non‐dysplastic BO patients. Older age and BO‐LGD carried a higher risk of ‘missed’ HGD/OAC. Non‐dysplastic BO patients were more often diagnosed with a ‘missed’ OAC (rather than HGD; 89%), compared with BO‐LGD patients (40%).ConclusionsApproximately one in 10 HGD/OAC cases are ‘missed’ at incident BO diagnosis, which is significant but lower than previous reports. However, ‘missed’ HGD/OAC cases represent only 0.26% of all BO patients.
Review of cutaneous penile lesions
Authors: Fortier Edouard , Cerruti Arnaud , Clec’h Christian LE , Bigot Pierre 
Published: October 2017

Introduction: Penile lesions often go undiagnosed and are difficult to identify for general practitioners and specialists, yet the stakes could be high. Indeed, the condition is highly varied and includes physiological variants, specific skin entities, genital dermatoses, genital ulcers, balanitis, premalignant lesions, and, finally, cancerous lesions. Knowledge of these entities can help to prevent overlooking potentially progressive lesions and diagnose cancerous lesions early so that patients can be offered conservative treatment, improving chances of survival. We review here these different lesions. Materials and methods and authors personal experience: A literature review was carried out in December 2016 using the Medline/Pubmed database, without any restrictions regarding the time period but limiting the review to studies in English or French. The main keywords used were “penile lesion”, “penile cancer”, “balanitis” and “premalignant lesion”. A specific review was performed for each type. All the pictures and cases came from our personal practice in our specific uro-dermatological consultation. All the patients gave us their informed consent for the utilization of their pictures. Results: We studied 66 references covering the field of benign and malignant lesions and their respective treatment. It is essential to take a medical history and perform a clinical examination, despite the fact that some lesions are not specific. A biopsy must be performed systematically in the case of all suspicious lesions. Conclusion: Lesions on genital organs in men are very diverse. Some are difficult to diagnose and treat, with the main challenge being early diagnosis of lesions with a high progressive potential in order to prevent dissemination and the need for mutilating surgery.
Evaluation of the Trends, Concomitant Procedures, and Complications With Open and Arthroscopic Rotator Cuff Repairs in the Medicare Population
Authors: Jensen Andrew R. , Cha Peter S. , Devana Sai K. , Ishmael Chad , Di Pauli von Treuheim Theo , D’Oro Anthony , Wang Jeffrey C. , McAllister David R. , Petrigliano Frank A. 
Published: October 2017

Background: Medicare insures the largest population of patients at risk for rotator cuff tears in the United States. Purpose: To evaluate the trends in incidence, concomitant procedures, and complications with open and arthroscopic rotator cuff repairs in Medicare patients. Study Design: Cohort study; Level of evidence, 3. Methods: All Medicare patients who had undergone open or arthroscopic rotator cuff repair from 2005 through 2011 were identified with a claims database. Annual incidence, concomitant procedures, and postoperative complications were compared between these 2 groups. Results: In total, 372,109 rotator cuff repairs were analyzed. The incidence of open repairs decreased (from 6.0 to 4.3 per 10,000 patients, P < .001) while the incidence of arthroscopic repairs increased (from 4.5 to 7.8 per 10,000 patients, P < .001) during the study period. Patients in the arthroscopic group were more likely to have undergone concomitant subacromial decompression than those in the open group (87% vs 35%, P < .001), and the annual incidence of concomitant biceps tenodesis increased for both groups (from 3.8% to 11% for open and 2.2% to 16% for arthroscopic, P < .001). While postoperative complications were infrequent, patients in the open group were more likely to be diagnosed with infection within 6 months (0.86% vs 0.37%, P < .001) but no more likely to undergo operative debridement (0.43% vs 0.26%, P = .08). Additionally, patients in the open group were more likely to undergo intervention for shoulder stiffness within 1 year (1.4% vs 1.1%, P = .01). Conclusion: In the Medicare population, arthroscopic rotator cuff repairs have increased in incidence and now represent the majority of rotator cuff repair surgery. Among concomitant procedures, subacromial decompression was most commonly performed despite evidence suggesting a lack of efficacy. Infections and stiffness were rare complications that were slightly but significantly more frequent in open rotator cuff repairs.
Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge
Authors: Latour Chloé , Besson-Fournier Céline , Gourbeyre Ophélie , Meynard Delphine , Roth Marie-Paule , Coppin Hélène 
Published: October 2017

Key Points
Loss of Bmp6 further represses hepcidin expression in the liver of Hjv knockout mice and markedly worsens the iron phenotype of females. Induction of hepcidin by LPS is not prevented by lack of Bmp6 and/or Hjv but its level poststimulation is blunted compared with controls.
Potential impact of complement regulator deficiencies on hemolytic reactions due to minor ABO-mismatched transfusions
Authors: Pandey Priyanka , Anani Waseem Q. , Gottschall Jerome L. , Denomme Gregory A. 
Published: October 2017

Key PointsAn in vitro model shows that hemolysis could be due to the presence of a subclinical PNH clone causing a negative C3b/d DAT. Changes to decay-accelerating factor and membrane inhibitor of reactive lysis may lead to overt hemolysis after minor mismatched transfusions.
The integration of a Podiatrist into an orthopaedic department: a cost‐consequences analysis
Authors: Walsh Tom P. , Ferris Linda R. , Cullen Nancy C. , Brown Christopher H. , Loughry Cathy J. , McCaffrey Nikki M. 
Published: October 2017

AbstractBackgroundThe aim of this study was to evaluate the cost‐consequences of a podiatry‐led triage clinic provided in an orthopaedic department relative to usual care for non‐urgent foot and ankle complaints in an Australian tertiary care hospital.MethodsAll new, non‐urgent foot and ankle patients seen in an outpatient orthopaedic department were included in this study. The patients seen between 2014 and 2015 by Orthopaedic Surgeons were considered ‘usual care’, the patients seen between 2015 and 2016 by a Podiatrist were considered the ‘Podiatry Triage Clinic’. Data on new and review patient appointments; the number of new patients / session; the number of appointments / patient; the number of patients discharged; the surgical conversion rate; staff time; and imaging use were collected. A cost‐consequences analysis, undertaken from a healthcare provider perspective (hospital) estimated the incremental resource use, costs and effects of the Podiatry Triage Clinic relative to usual care over a 12‐month period.ResultsThe Orthopaedic Surgeons and Podiatrist consulted with 72 and 212 new patients during the usual care and triage periods, respectively. The Podiatrist consulted with more new patients / session, mean (SD) of 3.6 (1.0) versus 0.7 (0.8), p < 0.001 and utilised less appointments / patient than the Orthopaedic Surgeons, mean (SD) of 1.3 (0.6) versus 1.9 (1.1), p < 0.001. The percentage of patients discharged without surgery was similar in the Podiatry Triage Clinic and usual care, 80.3% and 87.5% p = 0.135, respectively, but the surgical conversion rate was higher in the Podiatry Triage Clinic, 76.1% versus 12.5% p < 0.001. The total integrated appointment cost for the 12‐month usual care period was $32,744, which represented a cost of $454.78 / patient. The total appointment and imaging cost during the triage period was $19,999, representing $94.34 / patient. Further analysis, suggests that the projected annual saving of integrating a Podiatry Triage Clinic versus an orthopaedic clinic alone is $50,441.ConclusionsThe integration of a Podiatrist into an orthopaedic department significantly increases the number of patients seen, is cost‐effective, improves the surgical conversion rate and improves the utilisation of Orthopaedic Surgeons.
Cost-Effectiveness Analysis of Monthly Zoledronic Acid, Zoledronic Acid Every 3 Months, and Monthly Denosumab in Women With Breast Cancer and Skeletal Metastases: CALGB 70604 (Alliance)
Authors: Shapiro Charles L. , Moriarty James P. , Dusetzina Stacie , Himelstein Andrew L. , Foster Jared C. , Grubbs Stephen S. , Novotny Paul J. , Borah Bijan J. 
Published: October 2017

Purpose Skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasis cause considerable morbidity, decrements in quality of life, and costs to the health care system. The results of a recent large randomized trial (Cancer and Leukemia Group B/Alliance for Clinical Trials in Oncology [CALGB/Alliance 70604]) showed that zoledronic acid (ZA) every 3 months was noninferior to monthly ZA in reducing the risks of SREs. We sought to determine the cost-effectiveness (CE) of monthly ZA, ZA every 3 months, and monthly denosumab in women with breast cancer and skeletal metastases. Methods Using a Markov model, costs per SRE avoided were calculated for the three treatments. Sensitivity analyses were performed where denosumab SRE probabilities were assumed to be 50%, 75%, and 90% lower than the ZA SRE probabilities. Quality-adjusted life-years were also calculated. The analysis was from the US payer perspective. Results The mean costs of the denosumab treatment strategy are nine-fold higher than generic ZA every 3 months. Quality-adjusted life-years were virtually identical in all the three treatment arms; hence, the optimal treatment would be ZA every 3 months because it was the least costly treatment. The sensitivity analyses showed that relative to ZA every 3 months, the incremental costs per mean SRE avoided for denosumab ranged from $162,918 to $347,655. Conclusion ZA every 3 months was more CE in reducing the risks of SRE than monthly denosumab. This analysis was one of the first to incorporate the costs of generic ZA and one of the first independent CE analyses not sponsored by either Novartis or Amgen, the makers of ZA and denosumab, respectively. ZA every 3 months is the more CE option and more reasonable alternative to monthly denosumab.
Nurse prescribing: An essential requirement or an expensive luxury for school nurses?
Authors: Taylor Cathy , Bailey Victoria 
Published: October 2017

This small study sought to gain an understanding of the views and experiences of Specialist Community Public Health Nurses (SCPHN) School Nurse (SN) prescribers within two health boards in Wales. Aim and objectives: to explore the experiences of SN prescribers within Wales. The objectives (1) to conduct a review of the literature using a systematic approach to identify evidence where nurses have achieved or improved positive health outcomes through nurse prescribing (2) to identify whether SNs are currently prescribing at local level; (3) to identify the perceived benefits of nurse prescribing for the school nursing service (4) to identify possible barriers that may hinder SNs from prescribing. Research design: A predominantly qualitative approach was used to explore SNs views and experiences of prescribing in clinical practice. Findings: SN’s within this study are not using their nurse prescribing qualification, with many not feeling able to prescribe. Despite recognition of public health benefits, many felt uncertain about their role as nurse prescribers suggesting that additional organisational support was required if they were to remain competent within this role following qualification. Conclusions: A change in culture is required if SNs are to feel empowered to use their nurse prescribing qualification to improve outcomes for children and young people for the future.
Human Chorionic Gonadotropin Assays for Testicular Tumors: Closing the Gap between Clinical and Laboratory Practice
Authors: Ferraro Simona , Trevisiol Chiara , Gion Massimo , Panteghini Mauro 
Published: October 2017

Abstract

BACKGROUND
Clinical practice guidelines recommend the measurement of human chorionic gonadotropin (hCG) and/or hCGβ in serum for management of testicular germ cell tumors (GCTs). These guidelines, however, disregard relevant biochemical information on hCG variants to be detected for oncological application. We set out to provide a critical review of the clinical evidence together with a characterization of the selectivity of currently marketed hCG immunoassays, identifying assays suitable for management of GCTs.

CONTENT
Evidence sources in the available literature were critically appraised. Most instances of misdiagnosis and mismanagement of testicular GCTs have been associated with hCG results. According to the clinical evidence, 36% of patients with seminoma show an exclusive hCGβ increase, and 71% of patients with nonseminomatous GCTs (NSGCTs) show an increase of intact hCG and/or hCG + hCGβ, whereas the hCGβ increase in NSGCTs is variable according to the tumor stage and histology.

SUMMARY
hCG + hCGβ assays that display an equimolar recognition of hCG and hCGβ, or at least do not overtly underestimate hCGβ, may be employed for management of testicular GCTs. Assays that underestimate hCGβ are not recommended for oncological application. In addition to the hCG + hCGβ assay in service, an additional assay with broader selectivity for other hCG variants should be considered when false-negative or false-positive results are suspected on the basis of clinical data.