bluuebunny/crossref_metadata_2025_split huggingface dataset:
Margaret de Patta, une designer à l’esprit photo‑créatif. Vision en mouvement d’une œuvre plurielle
Authors: Givodan Joséphine 
Published: October 2024

« S’il nous manque le courage ou la vision de nous aventurer dans l’inexploré, nous allons inévitablement paraphraser les œuvres du passé ». Pour l’Américaine Margaret de Patta (1903-1965), la vocation du designer à produire des formes originales en adéquation avec son époque est inséparable d’une démarche expérimentale. L’auteure se propose d’examiner la façon dont la photographie s’est imposée au cours des années 1940 comme un instrument fondamental de sa recherche esthétique. Bagues, broches et pendentifs font écho à des photogrammes semi-abstraits, produits de sa rencontre avec des théories développées à Chicago par László Moholy-Nagy (1895-1946). Ces images, par définition uniques, sont rares en comparaison de son travail de joaillière dont on trouve plusieurs exemples dans d’importantes collections muséales comme celles de l’Art Institute de Chicago ou de la Smithsonian Institution de Washington. Elles n’en sont pas moins essentielles à la compréhension de son œuvre. Ancienne étudiante de László Moholy-Nagy, elle explore, elle aussi, les potentialités du papier sensible qu’elle met en contact direct avec divers objets choisis pour leurs qualités optiques. L’étude comparée de ces formes permet de mettre en évidence la place du photogramme dans le processus de conception esthétique et structurelle de ses bijoux.
L’œil, la main, et au‑delà. La collection photographique du musée des Arts décoratifs
Authors: Quéquet Sébastien 
Published: October 2024

Dès son origine en 1864, l’Union centrale des beaux-arts appliqués à l’industrie convoque la photographie, alors considérée comme l’un des vecteurs les plus efficaces pour la formation des ouvriers et des artisans qui trouvent ainsi modèles et sources d’inspiration. Au cours de son histoire, la bibliothèque du musée des Arts décoratifs reçoit en dons et en legs ou achète des photographies, souvent destinées à être classées par thèmes et collées dans de grands albums iconographiques. Parallèlement, le musée acquiert des photographies ayant pour vocation de documenter les collections – dont les créateurs ont par ailleurs pu faire don au musée –, mais aussi les manifestations culturelles du XIXe et du XXe siècle et la mode. Cet article dresse un portrait des pratiques sur cette collection photographique et leur évolution au cours de ces années.
Étude statistique sur corpus de l’alternance que / Ø en français parlé : quel est l’effet de la proximité communicationnelle ?
Authors: Ferreira Auphélie , Cunha Yanis da 
Published: October 2024

L’alternance entre séquence syndétique (je pense qu’il ne va pas venir) et asyndétique (je pense Ø c’est à onze heures) a été étudiée quantitativement en anglais (Jaeger, 2010) et en français québécois (Liang et al., 2021), mais pas en français métropolitain. Ainsi, en se concentrant sur les verbes croire et penser regroupés dans la catégorie des verbes « recteurs faibles », cet article présente une étude quantitative menée sur deux corpus de français parlé : le MPF (« Multicultural Paris French ») et le CEFC (« Corpus d’étude du français contemporain »). 1 249 occurrences de ces verbes ont été annotées manuellement pour un ensemble de facteurs linguistiques (personne, catégorie des sujets, présence de la négation, etc.) et non linguistiques (proximité / distance communicationnelle). À l’aide d’un modèle de régression logistique, la significativité d’un ensemble de facteurs hétérogènes dans le choix de construction est démontrée. Un intérêt particulier est porté sur le facteur communicationnel : les échanges caractérisés par la proximité et la connivence affichent une plus grande proportion de constructions asyndétiques.
Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Mice
Authors: Garcia-Flores Valeria , Liu Zhenjie , Romero Roberto , Pique-Regi Roger , Xu Yi , Miller Derek , Levenson Dustyn , Galaz Jose , Winters Andrew D , Farias-Jofre Marcelo , Panzer Jonathan J , Theis Kevin R , Gomez-Lopez Nardhy 
Published: October 2024

Abstract
Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammation, for which there is no established treatment. In this study, we propose homeostatic macrophages to prevent PTB and adverse neonatal outcomes caused by in utero sterile inflammation. Single-cell atlases of the maternal–fetal interface revealed that homeostatic maternal macrophages are reduced with human labor. M2 macrophage treatment prevented PTB and reduced adverse neonatal outcomes in mice with in utero sterile inflammation. Specifically, M2 macrophages halted premature labor by suppressing inflammatory responses in the amniotic cavity, including inflammasome activation, and mitigated placental and offspring lung inflammation. Moreover, M2 macrophages boosted gut inflammation in neonates and improved their ability to fight systemic bacterial infections. Our findings show that M2 macrophages are a promising strategy to mitigate PTB and improve neonatal outcomes resulting from in utero sterile inflammation.
Comparative evaluation of remineralizing efficacy of calcium sodium phosphosilicate, ginger, turmeric, and fluoride
Authors: Shayegan Amir , Arab Sara , Makanz Victor Manyong , Safavi Nicka 
Published: October 2024

ABSTRACT

Background:
White lesions, also known as white spots, are the earliest signs of tooth decay. At this stage, noninvasive preventive treatments, such as fluoride application, can help to slow down or even reverse the progression of white lesions. For decades, fluoride has held the spotlight as the go-to agent in oral preventive care, demonstrating significant remineralizing power. Recent scientific literature reveals a growing interest in alternative products as natural substances that demonstrate potential remineralizing effects on tooth enamel. This in vitro study aimed to evaluate the potential remineralizing effect of calcium sodium phosphosilicate (CSP), ginger, and turmeric.

Materials and Methods:
This in vitro study was designed to evaluate the remineralizing effects of various materials on the enamel of extracted human teeth. The aim was to compare the effectiveness of these different substances in promoting enamel remineralization. Enamel blocks were prepared and were divided into seven experimental groups: CSP, fluoride toothpaste, nonfluoride toothpaste, turmeric, ginger, fluoride varnish, and distilled water. In this study, sample mineralization is assessed through the quantitative photo-induced fluorescence test before demineralization, after demineralization, and after remineralization. Statistical analysis of the data was conducted using a one-factor analysis of variance test. The significance level was set at P < 0.05.

Results:
The best results were obtained by groups treated with turmeric (P < 0.0001), Enamelast fluoride varnish (P < 0.0001), and NovaMin (P < 0.01), as compared to other remineralizing treatments.

Conclusion:
While fluoride has undeniably revolutionized oral preventive care, the exploration of alternative products as natural substances and innovative compounds in recent scientific literature signals a shift in focus toward safer and potentially more diverse options.
Presbycusis and presbyvestibulopathy: Balance improvement after hearing loss restoration
Authors: Picciotti Pasqualina Maria , Di Cesare Tiziana , Libonati Fernanda Asprella , Libonati Giacinto Asprella , Paludetti Gaetano , Galli Jacopo 
Published: October 2024

Abstract

Objective:
The aim of the present study was to define if hearing relief can improve vestibular function and risk-to-fall.

Methods:
Fifteen hearing-impaired patients, 6 males and 9 females, aged ≥60 years (64–81 years, mean age 75.13 years), all affected by presbyvestibulopathy and presbycusis, with indication for bilateral hearing correction with hearing aids (HAs), underwent: the Conley Scale (for the fall risk assessment), the Dizziness Handicap Inventory (DHI) (quantifying dizziness-related physical and emotional symptoms and restrictions in daily activities), and the Corsi Blocks Task Test (assessing visuospatial working memory) before and 12 months after HAs fitting.

Results:
Mean basal scores were 2.8 ± 1.9 (Conley Scale); 30.1 ± 14.6 (DHI); and 3.5 ± 0.7 (Corsi span). Mean scores posthearing loss (HL) correction were 2.0 ± 1.6 (Conley scale); 24 ± 12.9 (DHI); 4.7 ± 1.6 (Corsi span). Comparing the scores pre- and postHAs fitting, we found an improvement of Conley Scale (P = 0.11), DHI (P = 0.11), and Corsi span (P = 0.05) after 1 year.

Conclusions:
The treatment of HL could be useful not only to reduce the risk of falls but also to improve the spatial memory and the quality of life related to imbalance.
Hearing screening in the newborns and the elderly
Authors: Martini Alessandro , Hatzopoulos Stavros 
Published: October 2024

Abstract
With the adoption of the Universal Neonatal Hearing Screening (UNHS) in the early 1990s, the approach to infant deafness has completely changed. The discussions of previous decades about the “infantile depistage” of deafness, the categories of infants “at risk,” and the age of rehabilitative intervention, have been completely reversed. Today, the diagnosis of infantile hearing loss has settled around the first 3 months of life, and consequently so has the eventual start of the rehabilitative process. Similar questions to UNHS are posed for the probable impact of hearing screening in the elderly and specially in groups where cognitive impairment is present. This short review paper summarizes various issues and developments in the area of newborn and adult hearing screening.
Opportunistic cervical cancer screening for elderly women without standardized screening
Authors: Li Kemin , Yin Rutie 
Published: October 2024

ABSTRACT

Objective:
This study aimed to investigate the importance of opportunistic cervical cancer screening for elderly women without standardized screening and also investigate the best opportunistic screening strategy.

Methods:
The participants were high-risk human papillomavirus (HPV)-positive elderly women, aged more than 65 years, who did not undergo standardized cervical cancer screening from June 2017 to June 2021. They had undergone an opportunistic cervical cancer screening. High-risk HPV distribution and the accuracy of different screening methods (only cytology, only HPV, HPV + cytology triage, and non-HPV 16/18 + cytology triage or HPV 16/18) for CINII + were analyzed.

Results:
A total of 848 elderly women with high-risk HPV infection were included, with 325 (38.3%) CINII + patients and 145 (17.1%) patients with invasive cancer. The top five HPV subtypes were HPV16, HPV52, HPV58, HPV53, and HPV56, and the infection rate was 31.4%, 21.9%, 19.7%, 11.6%, and 11.6%, respectively. The area under the receiver operating characteristic curve of the five screening strategies was 0.715 (0.681–0.750) (ASCUS+), 0.498 (0.458–0.538), 0.623 (0.584–0.663), 0.714 (0.680–0.748) (ASCUS+), and 0.698 (0.664–0.733) (ASCUS+).

Conclusion:
Elderly women who have not undergone standardized cervical cancer screening should be given a chance to be screened for cervical cancer; the standardized screening program is suitable for elderly women.
Lymph node metastasis risk factors in clinical stage IA3 lung adenocarcinoma
Authors: Zheng Yuanliang , Ju Sheng , Huang Risheng , Zhao Jun 
Published: October 2024

ABSTRACT

Background:
Lymph node metastasis is a poor prognostic factor for lung cancer. However, the risk of lymph node metastasis has not yet been clarified. This study was conducted to analyze the predictive factors for lymph node metastasis in patients with clinical-stage IA3 lung adenocarcinoma.

Methods:
We retrospectively analyzed all surgical patients with clinical stage IA3 lung adenocarcinoma admitted to our hospital from January 2017 to January 2022. Three hundred and thirty-four patients underwent lobectomy combined with systematic lymph node dissection. Univariate and multivariate logistic regression analyses were used to predict the risk factors of lymph node metastasis.

Results:
Of the 334 patients eligible for this study, the overall lymph node metastasis rate was 15.3%. There were 45 cases with N1 metastasis, 11 cases with N2 metastasis, and five cases with both N1 and N2 metastasis. The lymph node metastasis rate was 18.1% in patients with a consolidation tumor ratio (CTR) of >0.75, 57.9% in those with >5 ng/mL carcinoembryonic antigen (CEA), and 18.0% in those with a maximum standardized uptake value of >5. Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for CTR and CEA was 0.790 [95% confidence interval (CI): 0.727–0.853, P < 0.001] and 0.682 (95% CI: 0.591–0.773, P < 0.001), respectively. According to multivariate regression analysis, CEA (>5 ng/mL) [odds ratio (OR) = 3.05, P = 0.016] and CTR (>0.75) (OR = 2.75, P = 0.025) were significantly correlated with lymph node metastasis of clinical stage IA3 lung adenocarcinoma.

Conclusions:
CEA (>5 ng/mL) and CTR (>0.75) are two important predictors of lymph node metastasis in patients with clinical stage IA3 lung adenocarcinoma.
A combination of anti-PD-1 therapy and apatinib successfully treated a patient with EGFR mutation-negative advanced lung adenocarcinoma: A case report
Authors: Wang Jian , Li Shancheng , Zhang Lei , Zhang Xikun 
Published: October 2024

ABSTRACT
Here, we report the case of a patient with advanced lung adenocarcinoma with negative driver genes, who benefited from treatment with anti-programmed cell death-1 (anti-PD-1) therapy combined with a low dose of apatinib. From February 2020, the patient was treated with camrelizumab combined with pemetrexed disodium. The treatment regimen was adjusted to camrelizumab combined with a low dose of apatinib every 3 weeks because the patient could not tolerate the side effects of the previous chemotherapy, and camrelizumab led to reactive cutaneous capillary endothelial proliferation (RCCEP). After six cycles of camrelizumab plus a low dose of apatinib, the curative effect achieved was complete response (CR), with milder symptoms of RCCEP than before. Until the follow-up time of March 2021, the efficacy evaluation reached CR and the symptoms of RCCEP disappeared. This case report provides a theoretical basis for camrelizumab combined with a low dose of apatinib for the treatment ofcarcinoma patients with advanced lung adenocarcinoma with negative driver genes.
Evaluation of unimodal and multimodal information in health communication on GGO-related lung cancer screening: An eye-tracking study
Authors: Li Yuan , Peng Yue , Zhang Xiaoyu , Lyu Baihan , Zhang Xiaoxiao , Ji Ying , Liu Yan , Yang Linsong , Peng Zhongmin , Chen Jingxi , Zhao Liang 
Published: October 2024

ABSTRACT

Aims:
To find out a better propaganda and education plan for the popularization of the ground-glass opacities-related (GGO-related) lung cancer screening.

Methods and Material:
The control group took a lung cancer screening knowledge test directly before receiving the health education. By contrast, the experimental group took the same knowledge test after receiving health education. This study designed unimodal and multimodal materials about GGO-related lung cancer. The text and graph were considered unimodal information, while the video was multimodal information. According to the different information forms they were exposed to, the experimental group was further divided into text, graphic, and video groups. An eye-tracking system was performed to record eye-tracking data synchronously.

Results:
Compared with the control group, the knowledge test scores of each experimental group were remarkably improved. Furthermore, the graphic group had a significantly higher correct rate on the No. 7 question, while the video group had the lowest. In terms of saccades, the video group had significantly higher speed and amplitude of saccades than the other two groups. In terms of fixation, the interval duration, total duration of whole fixations, and a number of whole fixations of the graphic group were significantly lower than those of the other two groups, while the video group had the highest values for these variables.

Conclusions:
It was on the unimodal information, such as text and graphics, that people can spend less time and cost to achieve effective acquisition of GGO-related lung cancer screening knowledge.
A chemotherapy-free regimen improves prognosis in elderly diffuse large B-cell lymphoma patients with a low-performance status score: A Chinese multi-center real-world study
Authors: Teng Yan , Huang Ling , Chen Guiping , Jiang Xinmiao , Wei Xiaojuan , Guo Hanguo , Chen Feili , Liu Sichu , Yang Shaojiang , Cai Qingqing , Wang Ning , Pan Lu , Liang Zhanli , Zhu Zhigang , Zhao Ying , Li Wenyu 
Published: October 2024

ABSTRACT

Background:
Because patients with diffuse large B-cell lymphoma (DLBCL) aged >80 years old typically experience dismal outcomes, it is essential to improve disease control and reduce side effects in such patients.

Methods:
This was a multi-center retrospective study. Patients aged ≥80 years with pathologically confirmed DLBCL were treated in four centers in the Guangdong province between January 2010 and November 2020. Clinical data from patients receiving different treatment modalities were extracted from electronic medical records.

Results:
Finally, 50 patients aged ≥80 years were included; four (8.0%) refused treatment, 19 (38%) patients belonged to the chemotherapy-free group, and 27 (54%) patients were in the chemotherapy group. Patients receiving chemotherapy-free treatment had more often a non-germinal center B phenotype than those treated with chemotherapy (P = 0.006). The median progression-free survival (PFS) in the chemotherapy-free group was longer than that in the chemotherapy group (24.7 vs 6.3 months, P = 0.033). Good performance status (PS <2) was associated with higher PFS and overall survival (OS) (P = 0.03; P = 0.02, respectively). In patients with PS of ≥2, the median PFS and OS did not differ between the chemotherapy-free and chemotherapy groups (P = 0.391; P = 0.911, respectively). After stratifying patients with PS <2, the PFS and OS of the chemotherapy-free group were better than those of the chemotherapy group (58.1 vs 7.7 months, P = 0.006; 58.1 vs 26.5 months, P = 0.050). However, treatment-related toxicity did not differ between groups.

Conclusion:
PS was an independent prognostic factor of elderly DLBCL patients. Accordingly, patients aged ≥80 years with a PS of <2 could benefit from a chemotherapy-free regimen.
RAD51 135G>C polymorphism in esophageal cancer and meta-analysis in gastrointestinal tract cancers
Authors: Bali Jagmohan Singh , Sambyal Vasudha , Guleria Kamlesh , Mehrotra Sanjana , Singh Neeti Rajan , Uppal Manjit Singh , Manjari Mridu , Sudan Meena 
Published: October 2024

Background:
A functional single-nucleotide polymorphism (SNP), 135G>C in the 5'UTR of the RAD51 gene, affects gene transcription activity with implications for the repair of damaged DNA related to tumorigenesis. Previous limited reported genetic studies to link the 135G>C polymorphism of RAD51 gene to the risk of gastrointestinal tract (GIT) cancers, especially esophageal cancer (EC), have been inconclusive.

Materials and Methods:
The polymorphism was evaluated by RFLP-PCR in 252 EC patients and 252 healthy controls from Amritsar, Punjab, India, for case–control study. For a meta-analysis, a total of 78 studies on GIT cancers were assessed, out of which 14 eligible studies (including the present study) comprising 2842 cases and 3224 controls were included. Odds ratios (ORs) with 95% confidence intervals (CIs) and Chi-square test were used to assess the association in different inheritance models.

Results:
The GC genotype (OR: 0.45, 95% CI: 0.29–0.68) and C allele (OR: 0.52, 95% CI: 0.36–0.75) were significantly lower (P = 0.0005) in cases as compared to controls. There was no significant association with any genetic model in the meta-analysis.

Conclusion:
C allele provides protection for EC in the studied population contrary to previous reports in Polish, Chinese population probably due to ethic differences. Compared with previous meta-analysis on individual GIT cancers, present meta-analysis included all GIT cancers but found no association.
Discussion on the necessity of bilateral inguinal lymphatic area irradiation for cervical cancer with invasion of the lower one-third of the vagina
Authors: Cheng Haiyan , Wang Lina , Wang Le , Li Qi 
Published: October 2024

ABSTRACT

Context:
According to the National Comprehensive Cancer Network guidelines for cervical cancer, patients with cervical cancer invading the lower one-third of the vagina require bilateral inguinal lymphatic area preventive irradiation. However, it is not clear whether they need preventive inguinal area irradiation.

Aims:
The aim of this study is to evaluate the necessity of bilateral inguinal lymphatic area irradiation for patients with cervical cancer with invasion of the lower one-third of the vagina.

Settings and Design:
Patients without inguinal lymph node metastasis were divided into preventive radiotherapy and nonpreventive radiotherapy groups. The occurrence of inguinal skin damage, lower extremity edema, and femoral head necrosis was observed during and after treatment.

Methods and Material:
In total, 184 patients with cervical cancer with invasion of the lower one-third of the vagina were selected. A trial and control method was used to select 180 patients without inguinal lymph node metastasis.

Statistical Analysis:
Comparison between groups was performed using a t test. Data were enumerated using frequency (percentage), and comparison between groups was performed using a Chi-square test.

Results:
Imaging examination revealed inguinal lymph node enlargement in 7.07% of patients, and only four cases (2.17%) were further confirmed by pathology. The inguinal lymph node metastasis rate in these patients was very low. The prophylactic irradiation group showed a high occurrence rate of side injury. In the follow-up of both groups, no recurrence was detected in the inguinal lymph nodes.

Conclusions:
Prophylactic irradiation of inguinal lymph nodes is not essential for patients without pathological metastasis.
Safety Evaluation of the Novel Cocktail of Monoclonal Antibodies for Postexposure Prophylaxis in Category III Animal Exposures
Authors: Shankaraiah Ravish Haradanahalli , Masthi N. R. Ramesh , Poornima M. K. , Kiruffi Vinitha , Sowmyashree S. , Dutta Trayambak , Mahajan Manish , Desai Samir 
Published: October 2024

Introduction:
Rabies monoclonal antibody (mAb) is a life-saving immune-biological for postexposure prophylaxis (PEP) in all Category III animal exposures. A novel cocktail of mAbs derived using recombinant DNA technology is presently available for usage. The WHO recommends monitoring the clinical use and outcomes of mAb products.

Methods:
An open-label, postmarketing study was conducted at the anti-rabies clinic in the southern part of India. PEP was provided to all the study participants per the national guidelines. All the subjects were assessed for any adverse events (AEs) following PEP up to 35 days; if any, were treated free of cost at the study center.

Results:
The present study included 309 subjects across all age groups, 59.2% were adults, 33.3% of children, and 7.5% elderly. Majority of the patients were exposed to dogs (89.6%) and most of them had lacerations (86.3%) in different parts of their body. A total of 19 (6.2%) AEs were reported. All the AEs were local reactions, namely pain (2.6%), erythema (1.4%), tenderness (1%), induration (0.6%), and swelling (0.6%). All reported AEs were mild (Grade 1 severity) and resolved completely with symptomatic treatment.

Conclusion:
The novel cocktail of mAbs was safe for PEP in Category III animal exposures across all the age groups and supports its continued and improved usage for Universal Health Coverage to prevent rabies.