bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile Phone-Based Smoking-Cessation Intervention in Patients With Chronic Diseases in China: A Sequential Multiple Assignment Randomized Trial
Authors: Weng Xue , Song Chuyu , Liu Kefeng , Zhao Shengzhi , Yang Hongcui , Wang Man Ping 
Published: September 2024

Abstract

Introduction
Mobile phone-based interventions show promise for smoking cessation but often face low engagement. This study assessed the feasibility and preliminary effectiveness of a 2-phase, multi-component mobile phone-based smoking-cessation intervention for patients with chronic diseases.

Aims and Methods
This Sequential Multiple Assignment Randomized Trial recruited smokers with chronic diseases from hospitals in Zhuhai, China. Participants received brief cessation advice and were randomized to personalized chat support (PCS, n = 64) or group chat support (GCS, n = 64) for 1 month. At 1-month, PCS nonresponders (continuing smokers) were re-randomized to receive either multi-component optional support (MOS) or continued PCS for 2 months. GCS nonresponders were re-randomized to receive PCS or continued GCS. Responders continued with their initial intervention for 2 months. Feasibility outcomes included eligibility, participation, retention, intervention engagement, and satisfaction. Preliminary effectiveness was assessed by abstinence rates among nonresponders.

Results
Of 160 screened, 128 (all male, 46.1% aged ≤39 years) participated. At 1 month, 51 and 53 nonresponded to PCS and GCS, respectively. Of them, 26 were re-randomized to receive PCS-MOS and 26 to receive GCS-PCS. At 6 months, PCS-MOS showed a nonsignificant higher validated abstinence rate compared to PCS alone (11.5% vs. 4.2%, odds ratio [OR] 3.13, 95% CI: 0.30 to 32.31, p = .34), GCS-PCS showed a nonsignificant lower validated abstinence rate compared to GCS (0% vs. 11.1%, OR 0.50, 95% CI: 0.15 to 1.67, p = .26).

Conclusions
This trial showed the feasibility of leveraging hospital visits as teachable opportunities and integrating mobile phone-based smoking-cessation support into chronic disease management in China. Optional treatments alongside mobile support showed preliminary effectiveness.

Implications
(1) This study showed the feasibility and potential effectiveness of using a SMART design to personalize and adapt mobile phone-based smoking cessation interventions for patients with chronic diseases in China. (2) By leveraging teachable moments during hospital visits, the findings suggest that adaptive, personalized mHealth support can enhance smoking cessation outcomes, although not statistically significant. (3) The integration of mobile phone-based interventions into chronic disease management showed promise. (4) These findings support the need for broader implementation and optimization of mHealth interventions in clinical settings in China.

Trial registration
ClinicalTrials.gov, NCT06187142.
m5C and m6A modifications regulate the mobility of pumpkin CHOLINE KINASE 1 mRNA under chilling stress
Authors: Li Xiaojun , Wang Cuicui , Chen Ying , Liu Wenqian , Zhang Miao , Wang Naonao , Xiang Chenggang , Gao Lihong , Dong Yihan , Zhang Wenna 
Published: September 2024

Abstract
Mobile messenger RNAs (mRNAs) serve as crucial long-distance signaling molecules, responding to environmental stimuli in plants. Although many mobile transcripts have been identified, only a limited subset has been characterized as functional long-distance signals within specific plant species, raising an intriguing question about whether the prevalence of species specificity in mobile transcripts implies a divergence in the mechanisms governing mRNA mobility across distinct plant species. Our study delved into the notable case of CHOLINE KINASE 1 (CK1), an extensively studied instance of mobile mRNAs regulated by a transfer RNA–like sequence (TLS) in Arabidopsis (Arabidopsis thaliana). We established an association between mRNA mobility and length, independent of TLS numbers. Notably, neither the mobile mRNAs nor the mechanisms underpinning their mobility proved to be conserved across different plant species. The exclusive mobility of pumpkin CK1 mRNA under chilling stress was pivotal in enhancing the chilling tolerance of cucumber/pumpkin heterografts. Distinct from the TLS-mediated mobility of AtCK1 mRNA, the mobility of CmoCK1 mRNA is orchestrated by both m5C and m6A modifications, adding dimensions to our understanding of mRNA transport mechanisms.
CARDIA sleep ancillary study: study design and methods
Authors: Knutson Kristen L , Reid Kathryn J , Karanth Sunaina , Kim Nathan , Abbott Sabra M , Alexandria Shaina J , Harrington Katharine , Thomas S Justin , Lewis Cora E , Schreiner Pamela J , Carnethon Mercedes R 
Published: September 2024

Abstract
Sleep and circadian disturbances are common and are experienced more often by Black compared to White individuals. We conducted an observational study of sleep that was ancillary to an ongoing cohort study, Coronary Artery Disease in Young Adults (CARDIA). The goal of the ancillary study will be to examine potential determinants of sleep/circadian disparities between Black and White adults in future analyses. Herein we describe the study design and methodology. Our ancillary study coincided with the Year 35 examination of the CARDIA study and was conducted in two phases (due to the SARS-COV-2 pandemic). Phase 1 involved only questionnaires to assess chronotype, restless legs syndrome, and the household sleep environment. Phase 2 involved three additional questionnaires to assess sleep quality, daytime sleepiness and insomnia symptoms, as well as two sleep devices. Participants wore a wrist activity monitor to assess sleep–wake patterns and light levels for 7 days and a home sleep apnea test for 1 night. A subset also had devices objectively record light, temperature, and sound levels in their bedrooms for 7 days. Sample sizes ranged based on assessment from 2200 to 2400, completing Phase 1 questionnaires, 899 with valid wrist actigraphy data, and 619 with a valid sleep apnea test. The data will be part of the full CARDIA dataset, which is available to researchers.
Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome
Authors: Walrath Travis , Najarro Kevin M. , Giesy Lauren E. , Khair Shanawaj , Orlicky David J. , McMahan Rachel H. , Kovacs Elizabeth J. 
Published: September 2024

AbstractOne in six people are projected to be 65 years or older by 2050. As the population ages, better treatments for injuries that disproportionately impact the aged population will be needed. Clinical studies show that people aged 65 and older experience higher rates of morbidity and mortality after burn injury, including a greater incidence of pulmonary complications when compared to younger burn injured adults, which we and others believe is mediated, in part, by inflammation originating in the intestines. Herein, we use our clinically relevant model of scald burn injury in young and aged mice to determine whether cohousing aged mice with young mice or giving aged mice oral gavage of fecal material from young mice is sufficient to alter the microbiome of the aged mice and protect them from inflammation in the ileum and the lungs. Aged burn injured mice have less DNA expression of Bacteroidetes in the feces and an unhealthy Firmicutes/Bacteroidetes ratio. Both Bacteroidetes and the ratio of these two phyla are restored in aged burn injured by prior cohousing for a month with younger mice but not fecal transfer from young mice. This shift in the microbiome coincides with heightened expression of danger‐associated molecular patterns (DAMP), and pro‐inflammatory cytokine interleukin‐6 (il6) in the ileum and lung of aged, burn injured mice, and heightened antimicrobial peptide camp in the lung. Cohousing reverses DAMP expression in the ileum and lung, and cathelicidin‐related antimicrobial peptide protein (camp) in the lung, while fecal transfer heightened DAMPs while reducing camp in the lung, and also increased IL‐6 protein in the lungs. These results highlight the importance of the intestinal microbiome in mediating inflammation within the gut–lung axis, giving insights into potential future treatments in the clinic.
Gender and Authorship in Annals of Surgery: A nineteen-year review including the pandemic
Authors: Liang Jane W. , Chang Marcello , Stein Sharon L. , Salles Arghavan 
Published: September 2024

Objective:
We examined article submission data from the Annals of Surgery to assess gender bias in publishing.

Background:
Medicine has long been a male-dominated practice, particularly in surgical fields. A key criterion for promotion in academic medicine is the publication record. Thus, it is critical to understand the extent to which there are gendered disparities in access to publishing which may contribute to differences in career advancement, especially given the exacerbation of these disparities in the early part of the COVID-19 pandemic.

Methods:
Working with Annals of Surgery submission data (2005–2023), we assigned author genders using genderize.io. Primary outcomes were final decision on the article (acceptance or rejection) and time to decision. Differences were examined between first-author gender, last-author gender, and first-author/last-author gender pairs using regression and chi-squared analyses.

Results:
Men submit more articles than women. This gap widened until the number of submissions peaked in 2020, after which submissions from men appeared to decrease at a faster rate than those from women. Acceptance rates and time to decision have generally declined over time, but articles by women experienced, on average, higher acceptance rates and longer time to decision during recent years compared with those by men.

Conclusions:
Our data from a single journal suggest that the widening gender gap in submissions that existed before the pandemic may be narrowing, and overall research productivity of academic surgeons may be declining. Further work is needed to examine the long-term productivity and career trajectories of academic surgeons by gender accounting for the ongoing pandemic.
MACULAR HOLE SURGERY AND RETINAL TECTONICS
Authors: Pellegrini Marco , Adamo Ginevra , Vivarelli Chiara , Bizzarri Alice , Mondin Riccardo , Talli Pietro Maria , Nasini Francesco , Giannaccare Giuseppe , Mura Marco 
Published: September 2024

Purpose:
To evaluate the tangential retinal displacement occurring following macular hole (MH) surgery and to assess the impact of the internal limiting membrane (ILM) peeling size on the extent of the retinal movement.

Methods:
This retrospective study included patients with full-thickness MH undergoing 25-gauge pars plana vitrectomy with ILM peeling. Patients received either a small ILM peeling with a size of two-disk diameters or a large peeling extended up to the vascular arcades. Near-infrared retinal imaging was performed with the Spectral is (Heidelberg Engineering, Carlsbad, Germany) before and 6 months after the surgery. The tangential retinal displacement was evaluated comparing the optical flow of near-infrared images with a custom digital image analysis algorithm.

Results:
Forty-four eyes of 44 patients undergoing vitrectomy with small (n = 24) or large (n = 20) ILM peeling were included. An average overall displacement of 31.3 ± 22.8 µm toward the optic disk was observed after the surgery. Large ILM peeling was associated with a significantly higher overall displacement (P = 0.009), displacement in the central 4-mm circle (P < 0.001), and displacement in outer 8-mm ring (P = 0.001). Macular holes closure was achieved in 100% and 83.3% of patients in the large and small peeling group, respectively (P = 0.055).

Conclusion:
Pars plana vitrectomy with ILM peeling for MH results in a tangential retinal displacement toward the optic disk. A larger extent of the ILM peeling leads to a greater tangential movement, possibly improving the MH closure rate.
Myopic shift after primary intraocular lens implantation in unilateral cataract children and its association with preoperative ocular parameters
Authors: Li Yunqian , Jin Guangming , Tan Yuan , Chen Hui , Jin Jiaxin , Luo Lixia , Chen Weirong , Lin Haotian , Liu Yizhi , Liu Zhenzhen 
Published: September 2024

Purpose:
To assess the myopic shift in children with unilateral cataract undergoing primary intraocular lens (IOL) implantation and its association with preoperative ocular parameters.

Setting:
Single center.

Design:
Retrospective study.

Methods:
Children who underwent unilateral primary IOL implantation and were followed up for 3 years were included. Myopic shift and preoperative ocular parameters were compared between the treated and fellow eyes. The correlation between myopic shift and ocular parameters was assessed using partial correlation analysis. Potential factors influencing myopic shift were determined using linear regression analysis.

Results:
A total of 126 patients (252 eyes) were included. Longer preoperative axial length (AL) and steeper average keratometry (AK) in the treated eyes were noted in the whole cohort and patients aged 2 to <4 years (all P < .05). At 3 years postoperatively, mean myopic shift ranged from 3.53 diopters for children aged 1 to <2 years to 1.99 diopters for those aged 6 years and older. A greater myopic shift in the treated eyes was found in all, except children aged 6 years and older (P > .05). Preoperative interocular AL difference (IALD) was negatively correlated with myopic shift (r = 0.32, P < .001). Regression analysis revealed that younger age and smaller IALD were associated with greater myopic shift (P < .001 and P = .001, respectively).

Conclusions:
A greater myopic shift was observed in children with younger age at surgery and smaller IALD. To mitigate long-term anisometropia, selecting target refraction for unilateral pediatric cataracts should consider children's age, refractions of the fellow eyes, and preoperative IALD.
Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice
Authors: Morado-Urbina Carlos E. , Kato Jungo , Sandor Katalin , Vazquez-Mora Juan Antonio , Ängeby Möller Kristina , Simon Nils , Salcido Jaira , Martinez-Martinez Arisai , Munoz-Islas Enriqueta , Jimenez-Andrade Juan Miguel , Svensson Camilla I. 
Published: September 2024

Abstract
Nerve growth factor (NGF)-R100E is a mutated form of human recombinant NGF that reduces the binding of NGF to its p75NTR receptor while retaining its affinity toward the TrkA receptor. Here, we used human wild type NGF and NGF-R100E knock-in mice to investigate the effects of this NGF mutation on inflammation-induced pain-related behaviors and bone loss. The hNGF-R100E mutation did not alter the nerve fiber density in the sciatic nerve, ankle joint synovium, and skin of naïve mice. Withdrawal responses to mechanical, thermal, and cold stimuli before and after joint inflammation induced by intra-articular injection of complete Freund adjuvant (CFA) were similar between human recombinant nerve growth factor-wild type and hNGF-R100E male and female mice while weight bearing and gait analysis revealed significant differences. Intriguingly, hNGF-R100E male and female mice showed only mild changes, indicating lower degrees of deep joint–related pain compared to their wild type counterparts. Furthermore, micro-CT analysis demonstrated that hNGF-R100E female mice, but not males, were protected from CFA-induced bone loss, and mRNA analysis showed a different gene regulation indicating a sex-dependent relationship between NGF, inflammation, and bone loss. In conclusion, our study reveals that the hNGF-R100E mutation renders mice insensitive to inflammation-induced impact on joint loading and gait while preserving the development of the peripheral nociceptive neurons and sensitivity to punctate stimulation of the skin. Notably, the mutation uncovers a sex-dependent relationship between NGF and inflammation-induced bone loss. These findings offer valuable insights into NGF as a target for pain management and the interplay between NGF and bone architecture.
Introducing a Resource to Support Neonatal Nurse Engagement in Clinical Research©
Authors: Short Mary A. 
Published: September 2024

Purpose:
This paper introduces the Resource to Support Neonatal Nurse Engagement in Clinical Research© to educate and support engagement of nurses in study design and protocol review. The resource serves to promote collaboration between nurses and pharmaceutical researchers to advance the development of neonatal therapies.

Background:
Neonates remain therapeutic orphans, underserved by the drug development community. Off-label use of drugs in neonates negatively impacts the evaluation of their safety and efficacy. Although NICU nurses’ competencies are examples of expertise needed for well-designed clinical trials, nurses may have limited experience in providing insights.

Methods:
Resource development included a literature review and usability testing by multiple stakeholders.

Results:
Usability testing indicated the resource was comprehensive and relevant to pharmaceutical and nonpharmaceutical studies. Reviewers commented resource prompts are beneficial in assessing study feasibility.

Conclusion:
Sponsors of research need nurse engagement to improve feasibility and flexibility and prevent protocol deviations in clinical trials. Leveraging the “Resource to Support Neonatal Nurse Engagement in Clinical Research©” can enhance research education and foster engagement of nurses in neonatal research.

Implications for Practice:
The resource has implications for the nursing profession, the pharmaceutical industry, and the advancement of new therapies. Individual nurses benefit from education and a framework for research engagement. The profession benefits from enhanced visibility through research collaboration. The pharmaceutical industry gains valuable insights on neonatal care, family dynamics, and NICU standard of care. A resource to foster collaboration in the study development process is an important step for advancing new therapies for neonates.
Contraceptive Care in the Rheumatic Diseases
Authors: Luche Nicole , Talabi Mehret Birru 
Published: September 2024

Abstract
Contraception can help individuals with rheumatic and musculoskeletal diseases (RMDs) to avoid undesired pregnancies and improve reproductive outcomes. Despite the importance of contraception in the care of females with RMDs, evidence suggests that many of these individuals do not receive consistent or disease-specific counseling regarding contraceptive options. This includes female patients receiving teratogenic prescriptions as part of the management of their RMDs, or who have severe disease activity that might culminate in adverse pregnancy and perinatal outcomes. Contraceptive counseling can help females with RMDs who wish to prevent pregnancy to select a contraceptive method that is best for them.
We conducted a narrative review of the primary literature addressing reversible, prescription-based contraception for females with RMDs, framed by published guidelines on contraceptive safety. Many safe and effective contraceptive options are available for females with RMDs. Special considerations must be given to individuals with systemic lupus erythematosus, whose disease activity may be exacerbated by exogenous estrogen. Females with positive antiphospholipid antibodies should avoid estrogen-containing contraception due to an unacceptable risk of thrombosis and should conditionally avoid depot medroxyprogesterone acetate, which appears to have a prothrombotic signature. Limited contraceptive options are available to male patients. Contraceptive care for adolescents with RMDs can be extrapolated from guidelines written for adult patients, with the additional consideration of barrier protection for individuals at risk for sexually transmitted infections. Future research is needed to assess the effects of contraception use on rheumatic disease activity and side effects.
Reproductive Health in RA, Lupus, and APS
Authors: Zucchi Dina , Tani Chiara , Mosca Marta 
Published: September 2024

AbstractSystemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis are chronic autoimmune diseases affecting women of childbearing age. These diseases may impair fertility and fecundity, as well as complicate pregnancy and the puerperium in these patients including disease flare and obstetric complications on both the maternal and fetal side. For each patient, an appropriate preconceptional counseling with risk stratification is required, including assessment of disease activity, organ involvement, serological profile, and comorbidities.In cases of pregnancy, the aims of treatment are to prevent disease activity, to treat disease activity in cases of flare, and to prevent maternal and fetal complications such as preeclampsia or fetal loss. In all patients with these diseases, close clinical monitoring during pregnancy and puerperium is mandatory. This review aims to summarize the fertility issues in patients with systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis and to provide an update on pregnancy management and outcomes in these patients.
Hepatic Inflammatory Pseudotumor on 18F-FDG and 18F-FAP-42 PET/CT
Authors: Luo Yingqi , Qin Xiaowen , Liu Ying 
Published: September 2024

Abstract
Hepatic inflammatory pseudotumor is a rare benign disease. We describe the 18F-FDG and 18F-FAPI-42 PET/CT findings of hepatic inflammatory pseudotumor in a 57-year-old man. Compared with 18F-FDG, 18F-FAPI-42 PET/CT identified more lesions and showed more intense uptake within the lesions. This case illustrates that hepatic inflammatory pseudotumor should be contemplated in the differential diagnosis of liver lesions with increased 18F-FDG and 18F-FAPI-42 uptake. 18F-FAPI-42 PET/CT might be used as a helpful tool for evaluating hepatic inflammatory pseudotumor.
Triple Pedicled Flap Reconstruction for the Pharyngeal Necrosis: One-stage Suture of the Deltoid-pectoral Flap Harvesting Area
Authors: Onoda Satoshi , Katsuragi Ryohei , Kobayashi Kohta , Satake Toshihiko 
Published: September 2024

The patient was a 71-year-old male with hypopharyngeal carcinoma who underwent right-sided neck dissection for lymph node metastasis, adjuvant radiotherapy (70 Gy), and cisplatin chemotherapy, he developed neck inflammation with evidence of free air on computed tomography and subcutaneous fistula formation on laryngoscopy. After total laryngectomy, bilateral neck vessels were obscured by scar tissue secondary to radiotherapy and chronic inflammation. Pedicled pectoralis major (PM) flap was favored for reconstruction. A 20×7 cm PM flap was harvested from the right thoracic region, and the muscle body was harvested caudally to obliterate the dead space in the neck. After complete circumferential suturing, the dead space in the cervical region was filled by suturing the PM muscle body to the exposed cervical spine. A deltoid-pectoral (DP) flap was harvested from the right side and used to create the cephalic aspect of the permanent tracheostoma. In addition, a large right anterior pectoral flap was created lateral to the PM muscle, meticulously preserving the perforating intercostal artery branch during flap elevation. Lastly, the DP flap harvest site and neck defect were temporary. This case report presents a novel technique for laryngeal necrosis reconstruction using a combination of PM, DP, and anterior thoracic flaps. The approach achieved total suture closure of the DP flap harvest site, offering significant advantages. This technique should be considered in patients undergoing reconstruction with DP flaps.