bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural insights into G-quadruplex binding by metal complexes: implications for drug design
Authors: Prieto Otoya Tayler D. , McQuaid Kane T. , Cardin Christine J. 
Published: September 2024

AbstractG-quadruplex DNA secondary structures are formed in guanine-rich sequences and have been found to play an important role in regulating different biological processes. Indeed, guanine-rich sequences with the potential to form G-quadruplexes are present in different regions in the human genome, such as telomeres and the promoter region of different genes, including oncogene promoters. Thus, the rational design of small molecules capable of interacting, stabilising or damaging with high specificity these secondary structures represents an important strategy for the development of potent anticancer drugs. In this review, we highlight the interaction between G-quadruplex structures and their ligands, specifically emphasising the role of metal complexes. We provide detailed structural insight into the binding modes of metal complex-G-quadruplex interaction by analysing 18 sets of coordinates from X-ray and NMR currently available in the Protein Data Bank (PDB), with a primary focus on X-ray structural data.
Calibration of rotary axis angular positioning deviations in a six-axis robotic manipulator by using the R-Test
Authors: Cui Tianhao , Ibaraki Soichi 
Published: September 2024

AbstractPrediction accuracy of the kinematic model plays a pivotal role in offline numerical compensation for three-dimensional (3D) positioning error of a six-axis robotic manipulator. In addition to the Denavit-Hartenberg (D-H) error that was typically discussed in the analogous research, this paper proposes a novel scheme to identify the bidirectional angular positioning deviations of all the rotary axes without using the commercial laser tracker. This proposed scheme employs the R-Test, which is significantly more cost-efficient than a laser tracker employed in many past works. Compared to the conventional D-H model, significantly improved prediction performance of the proposed model was experimentally investigated on three rectangular paths covering the entire workspace. Experimental results indicate that the proposed scheme reduces the residual error from 505.2 to 215.2 mm, compared to 118.8 mm with a laser tracker, while maintaining a significantly lower cost that is 1/100 of a commercial laser tracker. Uncertainty analysis also clarify that when only the D-H error parameters are identified, as in many conventional works, the angular positioning deviations can be a major uncertainty contributor to the identification of the D-H errors. The proposed scheme does not require the R-Test locations to be calibrated, and its influence on the uncertainty in the identified errors is assessed.
Diagnostic reference levels in interventional neuroradiology procedures – a systematic review
Authors: Lopes Rogério , Teles Pedro , Santos Joana 
Published: September 2024

Abstract
Introduction
The establishment of diagnostic reference levels (DRLs) is challenge for interventional neuroradiology (INR) due to the complexity and variability of its procedures.

Objective
The main objective of this systematic review is to analyse and compare DRLs in fluoroscopy-guided procedures in INR.

Methods
An observational study reporting DRLs in INR procedures, specifically cerebral arteriography, cerebral aneurysm embolisation, cerebral thrombectomy, embolisation of arteriovenous malformations (AVM), arteriovenous fistulas (AVF), retinoblastoma embolisation, and spinal cord arteriography. Comprehensive literature searches for relevant studies published between 2017 and 2023 were conducted using the Scopus, PubMed, and Web of Science databases.

Results
A total of 303 articles were identified through an extensive literature search, with 159 removed due to duplication. The title and abstract of 144 studies were assessed and excluded if they did not meet the inclusion criteria. Thirty-one out of the 144 articles were selected for a thorough full-text screening. Twenty-one articles were included in the review after the complete text screening.

Conclusion
The different conditions of patients undergoing INR procedures pose a barrier to the standardization of DRLs; nevertheless, they are extremely important for monitoring and optimising radiological practices.
Outcomes by best response with hypomethylating agent plus venetoclax in adults with previously untreated acute myeloid leukemia
Authors: Jain Akriti G. , Volpe Virginia O. , Wang Chen , Ball Somedeb , Tobon Katherine , Chan Onyee , Padron Eric , Kuykendall Andrew , Lancet Jeffrey E. , Komrokji Rami , Sallman David A. , Sweet Kendra L. 
Published: September 2024

AbstractIntroduction: We aimed to compare outcomes of patients with AML treated with frontline hypomethylating agent and venetoclax (HMA + Ven) who achieved complete remission (CR), complete remission with partial hematologic recovery (CRh), complete remission with incomplete hematologic recovery (CRi), or morphologic leukemia-free state (MLFS) as defined by ELN 2022. Methods: Patients with AML seen at Moffitt Cancer Center between 2018 and 2022 and treated with HMA + Ven were retrospectively evaluated. Results: About 120 patients achieved blast clearance with best response of CR in 52 (43.3%), CRh in 22 (18.3%), CRi in 31 (25.8%) and MLFS in 15 (12.5%) patients. Greater proportion of patients with MLFS had a prior myeloid malignancy (p = 0.003) and were treated with prior HMA (p < 0.001). Patients that achieved MLFS as their best response had inferior OS compared to the CR/CRh/CRi cohort (8 months vs. 27 months; p < 0.001). RFS was also worse for the MLFS cohort. Conclusion: To the best of our knowledge, this is the largest study analyzing differences in outcomes of AML patients treated with HMA + Ven based on best response. We noted that prior myeloid malignancy and use of HMA led to more MLFS as best response compared to CR/CRi. The OS and RFS were inferior for MLFS cohort.
Physics-aware neural network-based parametric model-order reduction of the electromagnetic analysis for a coated component
Authors: Lee SiHun , Kang Seung-Hoon , Lee Sangmin , Shin SangJoon 
Published: September 2024

AbstractFinite element (FE) analysis is one of the most accurate methods for predicting electromagnetic field scatter; however, it presents a significant computational overhead. In this study, we propose a data-driven parametric model-order reduction (pMOR) framework to predict the scattered electromagnetic field of FE analysis. The surface impedance of a coated component is selected as parameter of analysis. A physics-aware (PA) neural network incorporated within a least-squares hierarchical-variational autoencoder (LSH-VAE) is selected for the data-driven pMOR method. The proposed PA-LSH-VAE framework directly accesses the scattered electromagnetic field represented by a large number of degrees of freedom (DOFs). Furthermore, it captures the behavior along with the variation of the complex-valued multi-parameters. A parallel computing approach is used to generate the training data efficiently. The PA-LSH-VAE framework is designed to handle over 2 million DOFs, providing satisfactory accuracy and exhibiting a second-order speed-up factor.
Self-perceived oral health in hemato-oncological patients and the relation to quality of life
Authors: Laheij Alexa M.G.A. , Dillen Linda M. , Nur Erfan , Raber-Durlacher Judith E. 
Published: September 2024

Abstract
Purpose
To assess the self-reported oral health and oral health-related quality of life of patients diagnosed with hemato-oncological disease.

Patients and methods
Data was collected through a digital questionnaire in collaboration with the Dutch patient organization Hematon. The questionnaires EORTC-QLQ-C30, EORTC-QLQ-OH15, shortened Xerostomia Inventory (XI), and the OHIP-14 were used.

Results
Seven hundred five patients were included (52.5% female, mean age 63.2 ± 10.1). The majority was diagnosed more than 2 years ago (86%) and had received treatment (81%) for their disease. Lymphoma, leukemia, and multiple myeloma were the most frequent malignancies. Chemotherapy alone, chemotherapy in combination with targeted therapy or immunotherapy, and myeloablative chemotherapy followed by autologous stem cell transplantation were the most common treatment modalities. The XI identified that 40.5% met the criteria for xerostomia. Other complaints included mouth soreness and sensitivity, gingival pain and bleeding, problems with teeth or with an ill-fitting denture. Despite reporting oral complaints, most patients experienced a rather good OH-QoL. A high xerostomia score led to a significantly lower OH-QoL. Female gender, history of stem cell transplantation, radiation to head and neck, and multiple daily medication use were significant predictors of xerostomia.

Conclusion
Patients with hematologic malignancies frequently reported a dry mouth and other oral complaints including mouth soreness and sensitivity, gingival pain and bleeding, and problems with teeth. Despite these oral complaints, most patients experienced a relatively good OH-QoL. Future longitudinal studies are needed, and health professionals should have an active role in providing oral supportive care based on patients’ individual needs.
A salutogenic approach towards children’s overall physical activities, coping behavior and resilience: a mediation analysis
Authors: Happ Elisabeth , Scholl-Grissemann Ursula , Schnitzer Martin 
Published: September 2024

Abstract
Aim
Physical activity (PA) has many benefits not only for a child’s physical development, but also for mental health and cognitive function which, in turn, results in broader social and environmental benefits. The World Health Organization announced recently that on average, children are not active enough. Following the salutogenic approach of questioning why people stay healthy as opposed to why they become ill, this study aims to examine the effects of overall physical activity (OPA) — including both 'non-sports physical activity' (including 'active play outdoors', 'active play indoors' and 'active mobility') and 'sports' — on children’s resilience and coping behavior.

Methods
Data was collected from 544 children in an age range of 6–19 years (online survey).

Results
Results show a two-dimensional construct including a non-sports physical activity dimension and a sports dimension (together, OPA) and the positive effects on children’s mental health. OPA as a concept contributes to the positive development of resilience skills in children. Furthermore, results show that the mediating role of coping behavior is another building block that can be targeted in terms of resilience in children.

Conclusion
Following the salutogenic approach to physical education and health, we posit that non-sports physical activity dimensions and sports dimensions are fundamental prerequisites for keeping children healthy. The OPA approach reveals joint implication pathways in addition to sport which help to increase children’s resilience.
Advanced Data Processing of THz-Time Domain Spectroscopy Data with Sinusoidally Moving Delay Lines
Authors: Vogel Tim , Saraceno Clara J. 
Published: September 2024

AbstractWe provide a comprehensive technical analysis of the data acquisition process with oscillating delay lines for Terahertz-time domain spectroscopy. The utilization of these rapid stages, particularly in high-repetition-rate systems, is known to enable an effective reduction of noise content through averaging. However, caution must be exercised to optimize the data averaging process, with the goal of significantly optimizing the dynamic range (DR) and signal-to-noise ratio (SNR). Here we discuss some pitfalls to avoid and the effect of improper data handling on the dynamic range obtainable. A free and open-source program, called parrot (Processing All Rapidly & Reliably Obtained THz-traces), is provided alongside this publication to overcome the discussed pitfalls and facilitate the acceleration of experimental setups and data analysis, thereby enhancing signal fidelity and reproducibility.
Safety, efficacy, and quality of life outcomes of pulsed field ablation in Japanese patients with atrial fibrillation: results from the PULSED AF trial
Authors: Yamane Teiichi , Sasano Tetsuo , Tomita Hirofumi , Aoyama Daisetsu , Miyazaki Shinsuke , Takigawa Masateru , Kimura Masaomi , Itoh Taihei , Yamashita Seigo , Selma Jada M , Cerkvenik Jeffrey , Verma Atul , Tada Hiroshi ,   on behalf of the PULSED AF Investigators
Published: September 2024

Abstract

Background
Pulsed field ablation (PFA), a novel treatment for atrial fibrillation (AF), has yet to be evaluated in a Japanese cohort.

Methods
In this sub-analysis of the PULSED AF trial, 12-month outcomes of paroxysmal AF (PAF) and persistent AF (PsAF) patients treated with PFA in four Japan centers were assessed. After a 90-day blanking period, primary efficacy was determined via freedom from a composite endpoint of acute procedural failure, arrhythmia recurrence, or antiarrhythmic drug escalation over 1 year. Patient improvement was evaluated via two quality of life (QoL) surveys (AFEQT and EQ-5D) at baseline and 12 months.

Results
The analysis included 32 patients, 16 PAF and 16 PsAF, with PAF patients averaging 61.1 ± 10.6 years and PsAF patients averaging 62.8 ± 11.5 years of age. Females made up 31% of PAF and 25% of PsAF cohorts. Acute pulmonary vein isolation was achieved in 100% of both cohorts. The primary efficacy success rate at 12 months was 75.0% for PAF and 56.3% for PsAF patients. No primary safety events occurred. The mean AFEQT score significantly increased for both PAF (25.9 points, p < 0.0001) and PsAF (13.2 points, p = 0.0002) patients, while the EQ-5D-5L score improved significantly for PAF (0.12 points, p = 0.048) patients but not for PsAF (0.04 points, p = 0.08) patients.

Conclusions
Similar to outcomes in the global cohort, ablation with the PulseSelect™ PFA catheter was efficient, effective, and safe in a Japanese population, resulting in improved QoL for PAF and PsAF patients.

Clinical trial registration
ClinicalTrials.gov Identifier: NCT04198701
Factors affecting sleep quality in hospitalised patients
Authors: Koshy Kavya , Gibney Matthew , O’Driscoll Denise M. , Ogeil Rowan P. , Young Alan C. 
Published: September 2024

Abstract
Introduction
Hospitalised patients are at increased risk of poor sleep quality which can negatively impact on recovery and quality of life. This study aimed to assess sleep quality in hospitalised patients and explore the factors associated with poor sleep.

Methods
Prospective data were collected from 84 respiratory ward inpatients at time of discharge using a Likert scale questionnaire on contributing factors to sleep quality. Differences between groups reporting good and poor quality sleep were recorded.

Results
Most participants (77%) described inpatient sleep quality to be worse or much worse compared to their home environment. Noise (39%), checking of vital signs (33%) and light (24%) were most frequently identified as factors disrupting sleep. Binary logistic regression analysis demonstrated that men (OR 2.8, CI 1.1–7.4, p = 0.037) and those in shared rooms (OR 3.9, CI 1.4–10.9, p = 0.009) were more likely to be affected by noise. Younger patients (OR 0.92, CI 0.88–0.96, p < 0.001) and those in shared rooms (OR 8.5 CI 1.9–37.9, p < 0.001) were more likely to be affected by light.

Conclusion
In conclusion, a high proportion of hospitalised respiratory patients on a medical ward reported poorer sleep quality compared to home due to operational interruptions and noise. Age, gender and room type further modified the sleep disruption. Future research should focus on whether strategies to reduce interruptions and noise will improve sleep quality and clinical outcomes.
Biotechnological potentials of surfactants in coal utilization: a review
Authors: Akimbekov Nuraly , Digel Ilya , Zhubanova Azhar , Tastambek Kuanysh T. , Tepecik Atakan , Sherelkhan Dinara 
Published: September 2024

AbstractThe quest for scientifically advanced and sustainable solutions is driven by growing environmental and economic issues associated with coal mining, processing, and utilization. Consequently, within the coal industry, there is a growing recognition of the potential of microbial applications in fostering innovative technologies. Microbial-based coal solubilization, coal beneficiation, and coal dust suppression are green alternatives to traditional thermochemical and leaching technologies and better meet the need for ecologically sound and economically viable choices. Surfactant-mediated approaches have emerged as powerful tools for modeling, simulation, and optimization of coal-microbial systems and continue to gain prominence in clean coal fuel production, particularly in microbiological co-processing, conversion, and beneficiation. Surfactants (surface-active agents) are amphiphilic compounds that can reduce surface tension and enhance the solubility of hydrophobic molecules. A wide range of surfactant properties can be achieved by either directly influencing microbial growth factors, stimulants, and substrates or indirectly serving as frothers, collectors, and modifiers in the processing and utilization of coal. This review highlights the significant biotechnological potential of surfactants by providing a thorough overview of their involvement in coal biodegradation, bioprocessing, and biobeneficiation, acknowledging their importance as crucial steps in coal consumption.
Comment on Logins – On the Connection between Normative Explanatory Reasons and Normative Reasoning Reasons
Authors: Schmidt Eva 
Published: September 2024

AbstractThe comment starts with a brief exposition of the Eroteric View put forth by Artūrs Logins. I then provide one friendly comment on the exact form of the normative question which is central to the view, and suggest that in addition to the question, ‘Why ought S to φ ?’, Logins should take the question, ‘Why is S permitted to φ?’ as definitive of normative reasons. In a more critical comment, I reflect on how normative explanatory reasons and normative reasoning reasons relate, calling into question Logins’s claim that the two kinds of reasons are fundamentally distinct. First, I argue that being a normative explanatory reason near enough guarantees being a normative reasoning reason; second, I argue that normative explanatory reasons as well as normative reasoning reasons can be weighed, and that they can be weighed against each other. But this causes trouble for the Eroteric View.
Phenotypic Diversity of Released South African Bred Potato Varieties for Tuber Yield and Processing Quality
Authors: Mbuma Ntombokulunga W. , Steyn Philippus J. , Laurie Sunette M. , Labuschagne Maryke T. , Bairu Michael W. 
Published: September 2024

Abstract Potato (Solanum tuberosum L.) is a nutritious starchy tuber crop consumed as a staple food in most potato growing countries. Its productivity and production are limited by climate change; thus, it is of utmost importance to tap into the diversity of germplasm resources, therefore, diversifying the potato varieties available for production. The objectives of this study were to determine the phenotypic diversity among the selected Agricultural Research Council-Vegetable, Industrial and Medicinal Plants (ARC-VIMP) potato varieties for tuber yields and processing quality and to determine the correlation between measured traits. Two imported and 22 local potato varieties were planted in three different environments in South Africa. Significant (P < 0.001) differences in the tested varieties across all environments were observed for all measured traits. High broad-sense heritability (> 0.6) was observed for most of the traits, except for fry colour and the yield of unmarketable tubers. Nine ARC varieties and three standard varieties were associated with high tuber yield and quality traits, indicating their suitability for the fresh market and processing industry. Variety Mondial and five ARC varieties were associated with high tuber yield, indicating their suitability for the fresh market. Varieties released between 2004 and 2021 had high tuber yield, dry matter and specific gravity compared to the standard varieties and varieties released between 1980 and 1999, although there were slight differences in the magnitudes of their traits measured. These varieties could be recommended for commercial production for specific markets and for use as potential parents for further genetic improvement of the potato crop.
Clinical impact of AI in radiology department management: a systematic review
Authors: Buijs Elvira , Maggioni Elena , Mazziotta Francesco , Lega Federico , Carrafiello Gianpaolo 
Published: September 2024

Abstract
Purpose
Artificial intelligence (AI) has revolutionized medical diagnosis and treatment. Breakthroughs in diagnostic applications make headlines, but AI in department administration (admin AI) likely deserves more attention. With the present study we conducted a systematic review of the literature on clinical impacts of admin AI in radiology.

Methods
Three electronic databases were searched for studies published in the last 5 years. Three independent reviewers evaluated the records using a tailored version of the Critical Appraisal Skills Program.

Results
Of the 1486 records retrieved, only six met the inclusion criteria for further analysis, signaling the scarcity of evidence for research into admin AI.

Conclusions
Despite the scarcity of studies, current evidence supports our hypothesis that admin AI holds promise for administrative application in radiology departments. Admin AI can directly benefit patient care and treatment outcomes by improving healthcare access and optimizing clinical processes. Furthermore, admin AI can be applied in error-prone administrative processes, allowing medical professionals to spend more time on direct clinical care. The scientific community should broaden its attention to include admin AI, as more real-world data are needed to quantify its benefits.

Limitations
This exploratory study lacks extensive quantitative data backing administrative AI. Further studies are warranted to quantify the impacts.