bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Hydrolyzed Fucoidan from The Brown Seaweed Sargassum Binderi Sonder Towards Human Breast Cancer T47d Cell Lines
Authors: Sinurat Ellya , Saepudin Endang , Qosthalani Fildzah Alfita 
Published: January 2018

Fucoidan, a sulfated heteropolysaccharide, consists of L-fucose and sulfate ester groups as the main component. Over the past three decades, fucoidan structures and bioactivities have been widely studied. The chemical components (fucose, galactose, small monosaccharides and also the sulfate) and the molecular weights of fucoidans from different brown seaweed species produce different characteristics and structures of fucoidan. The activity of fucoidan against cancer cells has been reported to be affected strongly by their sulfate content and molecular weight. Low-molecular-weight fucoidans tend to have higher solubility and easily penetrate into cancer cells. The objective of this study was to investigate the effect of hydrolyzed of fucoidan on its anti cancer activity againts the breast cancer T47D cells. In this study, the fucoidan from the brown seaweed Sargassum binderi Sonder was extracted using 0.1 N HCl and was depolymerized by acid hydrolysis at various times and concentrations. Result showed that fucoidan hydrolyzed with 1 M trifluoroacetic acid (TFA) for 1.5 hours reached the maximum depolymerization process and resulted in the decrement of molecular weight from 785.12 kDa to 5.79 kDa as well as sulfate content from 18.63% to 8.69%. The IC50 values of fucoidan and low molecular weight fucoidan against the breast cancer T47D cells were 60.03 mg/mL and 182.34 mg/ respectively. This result indicated that the sulfate content of fucoidan probably affected its anticancer bioactivities.
РОЗШИРЕННЯ СИРОВИННОЇ БАЗИ У ВИРОБНИЦТВІ КОМБІКОРМІВ ДЛЯ ЯЄЧНИХ КУРЕЙ
Authors: ЛАКІЗА О. В. 
Published: January 2018

У статті розглянуто сучасні напрями розширення сировинної бази у виробництві комбікормів для яєчних курей. Однією з найважливіших умов сучасного виробництва високоякісних комбікормів, білкових концентратів і преміксів є пошук і використання нової сировини рослинного і тваринного походження . При цьому питома вага зернових у цих продуктах складає не більше 50%, а в рецептах комбікормової галузі провідних країн 20-30%. Сучасні технології забезпечують застосування будь-якого кормового засобу, як важливої сировини для комбікормової промисловості, одержаної з відходів і побічних продуктів харчових виробництв, яким властиві високі кормові якості за невисокої вартості. Вітчизняні виробники комбікормів зараз змушені вирішувати проблему оптимізації використання злакових культур, зокрема, знизити вміст хлібних злаків в рецептурі комбікормів і вміст наповнювачів у рецептурі преміксів. Гостро стоїть проблема розширення асортименту кормової бази у виробництві комбікормів, преміксів, застосування більш дешевої кормової сировини з метою зниження собівартості готової продукції. Для рентабельного вирощування яєчних курей необхідні якісні корми, підібрані для кожного виду з урахуванням віку і фізіологічного стану птиці [1]. За останні роки виробництво яєць в Україні трималося на рівні 19 млрд шт. на рік, але починаючи з 2015 р. спостерігаємо суттєвий спад. Подібний спад виробництва пов’язаний із зменшенням поголів’я яєчних курей. Якщо розглядати виробництво яєць в розрізі категорій підприємств, можна констатувати, що в господарствах населення обсяг виробництва останніми роками також знижується, проте загалом темпи зменшення виробництва значно повільніші і менші, ніж у сільськогосподарських підприємств [2]. З метою розширення сировинної бази комбікормового виробництва і забезпечення необхідного рівня продуктивності яєчних курей, запропоновано введення концентрату кукурудзяно-фосфатидного кормового ( ККФК) в комбікорми. Особливості рецептури комбікормів досліджували на контрольних і дослідних рецептах. Розроблено рецептуру комбікормів із застосуванням ККФК для збалансованого раціону годівлі курей, встановлено збільшення рівня обмінної енергії, поживності комбікорму та його економічність.
ЕНЕРГОЄМНІСТЬ ЯК ЕНЕРГЕТИЧНА ХАРАКТЕРИСТИКА ТЕХНОЛОГІЧНОГО ПРОЦЕСУ ОЧИЩЕННЯ ЗЕРНА
Authors: КАРПОВА О. П. 
Published: January 2018

Раціональне використання електроенергії на зернопунктах, оснащених енергоємним технологічним обладнанням, особливо актуально тепер, коли прийнята Національна енергетична програма України з енергозбереження. Відомо, що 1 одиниця зекономленої електроенергії може зекономити не менш 5 одиниць первинних енергоресурсів. У даній роботі розглянута енергоємність як енергетична характеристика технологічного процесу очищення зерна, тому що вона є найбільш інформативним показником для визначення енергозберігаючих режимів роботи. Для визначення впливу режимів роботи обладнання на використання електроенергії в робочих процесах очищення зерна базових зерноочисних агрегатів були визначені найбільш суттєві фактори, які впливають на енергоємність процесу очищення зерна. При дослідженні впливу технологічних факторів на енергоємність технологічних процесів очищення зерна було проведено багатофакторний експеримент. Це дозволило оцінити вплив того або іншого фактора на енергоємність процесу очищення зерна. Досліджувався процес очищення насіннєвого та продовольчого зерна на агрегатах ЗАВ-20, ЗАР-5, які є базовими зерноочисними агрегатами, на основі яких розроблені інші агрегати, які випускає промисловість. В результаті розрахунків отримані рівняння регресії для визначення питомих витрат електроенергії в залежності від технологічних факторів. Натурні експерименти підтвердили адекватність математичних моделей у вигляді рівнянь регресії і ефективність використаного методу багатофакторного експерименту. Результати теоретичних і експериментальних досліджень енергоємності технологічних процесів очищення зерна відрізняються в середньому не більше ніж на ±2 %. Вони показали можливість обґрунтування та розробки науково-обґрунтованих норм електроспоживання на зернопунктах, тому що найбільш діючим важелем проведення енергозберігаючої політики, регульованої законодавством, є встановлення нормативів витрати електроенергії і стандартів енергоефективності, недотримання яких спричиняє, найчастіше, фінансову відповідальність.
ANÁLISE DO PROCESSO FORMATIVO DE UMA RESIDÊNCIA DE ENFERMAGEM EM TERAPIA INTENSIVA
Authors: Santos Adailton Da Silva dos , Castro Lívia Magalhães Costa , Fagundes Norma Carapiá , Vieira Débora Feijó Villas Bôas 
Published: January 2018

<p>Objetivo: analisar o processo formativo de uma Residência de Enfermagem em Terapia Intensiva sob a ótica dos egressos. Método: estudo descritivo, exploratório e quantitativo. Participaram todos os egressos da residência entre os anos de 2004 a 2012. Deles, 91 retornaram o instrumento de pesquisa enviado por e-mail e preenchido entre julho e setembro de 2013. Os dados foram analisados através da estatística descritiva. Resultados: o currículo teve maior frequência de avaliação satisfatória (87,9%); a relação entre aulas teóricas e práticas (44%) e o relacionamento com a preceptoria (34,1%) destacaram-se como avaliação intermediária. Todos relataram desenvolver competências para o mercado laboral e apenas 3,3% informaram alguma insatisfação com a residência. Conclusão: a pesquisa identificou que programas de residência devem ter propostas avaliativas que analisem diversos aspectos relacionados ao curso, além da avaliação cognitiva dos residentes. Recomenda-se implementar projetos de educação permanente que abordem atualização científica e formação pedagógica de preceptores e coordenadores.</p><p><br />Descritores: Enfermagem. Internato não médico. Educação em enfermagem. Unidades de terapia intensiva.</p>
Study of the efficiency of moving bed biofilm reactor (MBBR) in LAS Anionic Detergent removal from hospital wastewater: determination of removing model according to response surface methodology (RSM)
Authors: Shokoohi Reza , Torkshavand Zahra , Zolghadnasab Hassan , Alikhani Mohammad Yousef , Hemmat Meisam Sedighi 
Published: January 2018

Abstract
Detergents are considered one of the important pollutants in hospital wastewater. Achieving efficient and bio-friendly methods for the removal of these pollutants is considered as a concern for environmental researchers. This study aims at studying the efficiency of a moving bed biofilm reactor (MBBR) system for removing linear alkyl benzene sulfonate (LAS) from hospital wastewater with utilization of response surface methodology (RSM). The present study was carried out on a reactor with continuous hydraulic flow using media k1 at pilot scale to remove detergent from hospital wastewater. The effect of independent variables including contact time, percentage of media filling and mixed liquor suspended solids (MLSS) concentration of 1000-3000 mg/l on the system efficiency were assessed. Methylene blue active substances (MBAS) and chemical oxygen demand (COD) 750-850 mg/l were used by closed laboratory method in order to measure the concentration of LAS. The results revealed that the removal efficiency of LAS detergent and COD using media k1, retention time of 24 hours, and MLSS concentration of around 3,000 mg/l were 92.3 and 95.8%, respectively. The results showed that the MBBR system as a bio-friendly compatible method has high efficiency in removing detergents from hospital wastewater and can achieve standard output effluent in acceptable time.
The Delicate Balance between the Good and the Bad IL-1 Proinflammatory Effects in Endometriosis
Authors: Sikora Justyna , Ferrero Simone , Mielczarek-Palacz Aleksandra , Kondera-Anasz Zdzislawa 
Published: January 2018

Background:
Endometriosis is an inflammatory gynaecological disease with an
associated chronic inflammation. Interleukin(IL)-1 is one of the most important immune and
proinflammatory factors, produced mainly by monocytes and macrophages. Studies indicate
the role of the cytokine from IL-1 family in endometrium-related disorders, particularly in endometriosis.

Methods:
The information about the impact of cytokine from IL-1 cytokine family on the
pathogenesis and development of endometriosis was obtained with an electronic literature
search based on the PubMed and Medline databases, spanning the period of January 1950 to
July 2017 and includes associated references in the published studies.

Results:
The impairment of the IL-1 family cytokine-network may lead to changes in the activation
of immune system in the peritoneal cavity of women with endometriosis. The aberrant
ectopic endometrial cell properties of adhesion, implantation and proliferation may be the
result of a reduced suppressive capacity controlling the IL-1. The imbalance between IL-1α,
pro-IL-1β, mature IL-1β and sIL-1R2 and sIL-1RAcP in the peritoneal fluid and serum of
women with endometriosis may be linked to the ability of transforming an acute inflammation
into a chronic one. Despite the fact that peritoneal macrophages secrete more antiinflammatory
IL-1Ra and less proinflammatory IL-1 in the peritoneal cavity in affected
women, the inflammation still develops.

Conclusions:

This observation clearly suggested a significant inadequacy in the specific regulatory
mechanisms of IL-1 activity at the peritoneal cavity level. The imbalance between all
studied cytokines in endometriosis may escalate peritoneal inflammation and, in consequence,
develop endometriosis.
Mesenchymal Stem Cell Therapy in Intracerebral Haemorrhagic Stroke
Authors: Bedini Gloria , Bersano Anna , Zanier Elisa R. , Pischiutta Francesca , Parati Eugenio A. 
Published: January 2018

Background:
Spontaneous intracerebral haemorrhage (ICH) is a relatively
common fatal disease, with an overall global incidence estimated at 24.6 per 100,000 person-
years. Given the high degree of morbidity and mortality associated with ICH, therapies
that may have neuroprotective effects are of increasing interest to clinicians. In this
last context, cell therapies offer the promise of improving the disease course which cannot
be addressed adequately by existing treatments.

Objective:
The aim of this review is to evaluate the protective effects and molecular
mechanisms of mesenchymal stem cells (MSCs) on haemorrhagic brain following ICH.
We also discuss possible emerging therapeutic approaches worth of further research.

Methods and Results:

The available literature on the therapeutic potential of MSCs in
ICH animal models clearly demonstrated that MSCs enhance the functional recovery and
reduce the volume of the infarct size exerting anti-inflammatory and angiogenic properties.
However, the quality of the original articles investigating the efficacy of stem cell
therapies in ICH animal models is still poor and the lack of ICH clinical trial does not
permit to reach any relevant conclusions.

Conclusion:
Further studies have to be implemented in order to achieve standardized
methods of MSCs isolation, characterization and administration to improve ICH treatments
with MSCs or MSC-derived products.
Nutraceutical Insight into Vegetables and their Potential for Nutrition Mediated Healthcare
Authors: Saiwal Nidhi , Dahiya Mandeep , Dureja Harish 
Published: January 2018

Background:The connection between food and good health is not a new concept. Vegetables are being used as a source of nutrition since long. Dietary active components are essential for the normal functioning of the human body.Methods:The study basically involves all the three categories of research methodologies, including analytic, descriptive and historical. It involves secondary data from scientific reports, books, and journals.Results:Vegetables can be considered as nutraceuticals since they supply bioactive compounds effective in decreasing the risk of many diseases. Vegetables are considered to be protective foods since they contain low calories and higher vitamins and minerals. Vegetables are potentially suitable against civilization diseases, which are caused by the lack of nutrients such as omega-3 fatty acids, antioxidants (vitamin E, vitamin C, β-carotene, selenium, zinc, cryptoxanthin, lycopene etc), and other micronutrients.Conclusion:The presence of bioactive compounds like phytochemicals offers nutraceutical values to vegetables. Nutraceutical rich vegetables have been established to have a role in gastrointestinal disorders, cardiovascular diseases, cancer, diabetes and other diseases. Vegetables and fruits not only have the potential to stop the growth of disease but also can cure many diseases and boost the immune system.
Hypoplastic Left Circumflex Coronary Artery: Imaging Findings with Coronary Computed Tomography Angiography - A Case Report
Authors: Sayit Asli Tanrivermis , Celenk Cetin 
Published: January 2018

<P>Background: Hypoplastic coronary artery disease is a rare congenital coronary artery anomaly. It is often detected incidentally, and its true incidence in the general population is not known. </P><P> Discussion: Symptoms of HCAD are syncope, palpitations, dyspnea, and chest pain. Also, arrhythmia and myocardial infarction can be seen; these can cause sudden death, especially in athletes and young people. Diagnosis is often made at autopsy.Conclusion:Here, we present the case of a 39-year-old male with isolated hypoplasia of the left circumflex artery detected by coronary Computed Tomography (CT) angiography who complained of palpitation.</P>
Nanoemulsion Strategy for Ursolic and Oleanic Acids Isolates from Plumeria Obtusa Improves Antioxidant and Cytotoxic Activity in Melanoma Cells
Authors: Alvarado Helen L. , Calpena Ana C. , Garduño-Ramírez María L. , Ortiz Raúl , Melguizo Consolación , Prados José C. , Clares Beatriz 
Published: January 2018

Background:
Triterpenoids are an important class of natural bioactive products present in many
medicinal plants.

Objective:
The aim of present study is to investigate the antioxidant and anticarcinogenic potential of Oleanolic
Acid (OA) and Ursolic Acid (UA) on B16 murine melanoma cell line isolated from Plumeria obtusa, free and
loaded in a nanoemulsion (NEm) system.

Methods:
The nanoemulsion was characterized by dynamic light scattering, transmission electron microscopy.
The viscosity was also evaluated. The antioxidant activity was determined by the reduction of 2,2-diphenyl-2-
picrylhydrazyl (DPPH) free radical. In vitro proliferation studies were determined using the sulforhodamine-B
method.

Results:
OA/UA natural mixture exhibited high percentage of inhibition of DPPH (86.06% and 85.12%, with
and without irradiation). Percentages of inhibition higher than 85% in samples with and without ultraviolet
irradiation were recorded when loaded in the NEm system. The natural mixture incorporated into the NEm
showed cytotoxic activity from 2.9 µM, whereas the free compounds from 17.4 µM.

Conclusion:
We conclude that these pentacyclic triterpenes loaded in a NEm system could be considered as a
new potential tool for further investigation as anticancer agents.
Design of GA and Ontology based NLP Frameworks for Online Opinion Mining
Authors: Sharma Manik , Singh Gurvinder , Singh Rajinder 
Published: January 2018

Background:
For almost every domain, a tremendous degree of data is accessible in an
online and offline mode. Billions of users are daily posting their views or opinions by using different
online applications like WhatsApp, Facebook, Twitter, Blogs, Instagram etc.

Objective:
These reviews are constructive for the progress of the venture, civilization, state and even nation.
However, this momentous amount of information is useful only if it is collectively and effectively
mined.

Methodology:
Opinion mining is used to extract the thoughts, expression, emotions, critics, appraisal
from the data posted by different persons. It is one of the prevailing research techniques that coalesce
and employ the features from natural language processing. Here, an amalgamated approach has been
employed to mine online reviews.

Results:
To improve the results of genetic algorithm based opining mining patent, here, a hybrid genetic
algorithm and ontology based 3-tier natural language processing framework named GAO_NLP_OM has
been designed. First tier is used for preprocessing and corrosion of the sentences. Middle tier is composed
of genetic algorithm based searching module, ontology for English sentences, base words for the
review, complete set of English words with item and their features. Genetic algorithm is used to expedite
the polarity mining process. The last tier is liable for semantic, discourse and feature summarization.
Furthermore, the use of ontology assists in progressing more accurate opinion mining model.

Conclusion:
GAO_NLP_OM is supposed to improve the performance of genetic algorithm based opinion
mining patent. The amalgamation of genetic algorithm, ontology and natural language processing
seems to produce fast and more precise results. The proposed framework is able to mine simple as well
as compound sentences. However, affirmative preceded interrogative, hidden feature and mixed language
sentences still be a challenge for the proposed framework.
A STUDY OF STOOL SAMPLE FROM HIV POSITIVE AND HIV NEGATIVE AT ANDHRA PRADESH.
Authors: Obulesu Gundala , Ar Hanumanthappa , E Prabakar Reddy 
Published: January 2018

Objective: The objective of this study is to investigate the variations, if any, in the types of intestinal parasites in HIV-positive and HIV-negative individuals.Methods: For their HIV status in our laboratory by enzyme-linked immunoasorbant assay and TRIDOT, sample stool, macroscopic and microscopic examination, formal-ether concentration technique f, saline wet mount, iodine wet mount, modified acid-fast stain. Results: For the purpose of statistical analysis, the enteric parasites are divided into the coccidian group (Cryptosporidium+Isospora belli) and conventional enteric parasites (Entamoeba histolytica, Giardia intestinalis, and Ascaris lumbricoides), and enteric parasitic infection is more common in HIV-positive patients with diarrhea than HIV-positive patient without diarrhea or HIV-negative individuals.Conclusion: The study period of 1 year and 8 months revealed that it is difficult to locate/identify a HIV-positive person in a place like Kadapa on account of confidentiality/lack of awareness among the population. Detection of intestinal parasites is 17.3% in HIV-positive patients and 12% in HIV-negative individuals.
The 'Shequ Construction' Programme and the Chinese Communist Party
Authors: Kojima Kazuko , Kokubun Ryosei 
Published: January 2018

In recent years, the community development programme called 'Shequ
Construction' has been making rapid progress in China. The discussion
surrounding the programme focuses on how to adjust the relationship between
the street offices (which fall under the jurisdiction of the government) and the
shequ residents' committees (defined as the people's self-governing entity).
The programme has also led the debate over the position and role of the
Chinese Communist Party (CCP) in the newly reconstructed shequ. While the
party's Organization Department proposes the unification of the shequ party
branches and shequ residents' committees, others maintain that the shequ party
branch should be differentiated from the shequ residents' committee, which is
still viewed as an agent of government. They say 'the greatest advantage of the
CCP is that it is the embodiment of social power and it is not a non-socialist
external force like the administrative organ'. Their proposal raises further
questions: How should the party change its direction and guidance within the
framework of the separation of government and society? Will this affect the
party's ability to continue to provide society with effective 'guidance' and
become representative of society? This paper will provide some clues to help
answer these questions.
Norms, Values and Cynical Games with Party Ideology
Authors: Bakken Børge 
Published: January 2018

The Chinese Communist Party is based on an ideology that was once fundamentally
linked to social norms and values. The original charisma of the party
and its leaders seems to have gone in the direction predicted by Max Weber: that
charisma cannot stand the test of everyday routines; it will eventually be rationalized
and bureaucratized. The party's slogan of 'three representations' seems to
reach out to the 'new social strata,' allowing entry to those who 'became rich first,'
namely the entrepreneurs. At the same time, the party struggles to redefine the
Marxist paradigm of exploitation in a situation where workers increasingly live
under conditions akin to those in England at the time of the Industrial Revolution.
Sweeping changes are being implemented but without any modification to
the verbal baggage of socialist propaganda.
Process Ambiguities in Sino-Danish Busi ness Negotiations
Authors: Kumar Rajesh , Worm Verner 
Published: January 2018

The article analyses the role played by process ambiguities in Sino-Danish
busi ness negotiations. Process ambiguities refer to perceived expectational
inconsistency concerning (i) appropriate forms of behaviour; (ii) attributional
judgements; and (iii) structuring of the negotiation process. These ambiguities
stem from dif fer enc es in negotiation scripts across Chinese and Danish cultures.
The essential ar gu ment being advanced here is that it is the effective and/or
the ineffective management of process ambiguities that shapes the evolution
of the negotiating dynamic be tween Danish and Chinese business people. An
inductive model of Sino-Dan ish business negotiations is developed that is
based on 24 interviews conducted with Danish expatriate managers in China
and 4 interviews with Chinese working in Danish companies. Implications for
research and practice are discussed.