bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic Anatomy of the Tensor Fold and Anterior Attic
Authors: Li Bin , Doan Phi , Gruhl Robert R. , Rubini Alessia , Marchioni Daniele , Fina Manuela 
Published: December 2017

ObjectivesThe objectives of the study were to (1) study the anatomical variations of the tensor fold and its anatomic relation with transverse crest, supratubal recess, and anterior epitympanic space and (2) explore the most appropriate endoscopic surgical approach to each type of the tensor fold variants.Study DesignCadaver dissection study.SettingTemporal bone dissection laboratory.Subjects and MethodsTwenty‐eight human temporal bones (26 preserved and 2 fresh) were dissected through an endoscopic transcanal approach between September 2016 and June 2017. The anatomical variations of the tensor fold, transverse crest, supratubal recess, and anterior epitympanic space were studied before and after removing ossicles.ResultsThree different tensor fold orientations were observed: vertical (type A, 11/28, 39.3%) with attachment to the transverse crest, oblique (type B, 13/28, 46.4%) with attachment to the anterior tegmen tympani, and horizontal (type C, 4/28, 14.3%) with attachment to the tensor tympani canal. The tensor fold was a complete membrane in 20 of 28 (71.4%) specimens, preventing direct ventilation between the supratubal recess and anterior epitympanic space. We identified 3 surgical endoscopic approaches, which allowed visualization of the tensor fold without removing the ossicles.ConclusionsThe orientation of the tensor fold is the determining structure that dictates the conformation and limits of the epitympanic space. We propose a classification of the tensor fold based on 3 anatomical variants. We also describe 3 different minimally invasive endoscopic approaches to identify the orientation of the tensor fold while maintaining ossicular chain continuity.
Is the effect of coping styles disease specific? Relationships with emotional distress and quality of life in acquired brain injury and multiple sclerosis
Authors: Brands Ingrid , Bol Yvonne , Stapert Sven , Köhler Sebastian , van Heugten Caroline 
Published: December 2017

Objective: To investigate the use of coping styles and the relationships linking coping to emotional distress and quality of life in patients with acquired brain injury and multiple sclerosis. Method: Cross-sectional cohort study of 143 patients with acquired brain injury and 310 patients with multiple sclerosis in the chronic stage. Quality of life was measured with the Life Satisfaction Questionnaire (LiSat-9), coping styles with the Coping Inventory for Stressful Situations (CISS-T, task-oriented; CISS-E, emotion-oriented; CISS-A, avoidance), emotional distress with the Hospital Anxiety and Depression Scale (HADS). Results: Coping styles did not differ between types of multiple sclerosis and varied only little with regard to severity of disease. In both patient groups, task-oriented coping was most used followed by avoidance and emotion-oriented coping. Patients with multiple sclerosis used all styles to a greater extent. In acquired brain injury, lower CISS-E and lower HADS scores were associated with higher LiSat-9 scores. CISS-E had a direct effect on LiSat-9 and an indirect effect via HADS. In multiple sclerosis, next to lower CISS-E and lower HADS scores, higher CISS-A scores were also associated with higher LiSat-9 scores. CISS-E had an indirect effect and CISS-A had a direct and indirect effect on LiSat-9. Conclusion: In both patient groups, coping patterns are similar, and emotion-oriented coping negatively influences quality of life. Additionally, in multiple sclerosis, seeking emotional support and distraction (CISS-A) was positively associated with quality of life. Interventions to improve adaptive coping could be organized within a neurorehabilitation setting for both patient groups together.
Headache in the pediatric emergency department: A 5-year retrospective study
Authors: Rossi Roberta , Versace Antonia , Lauria Barbara , Grasso Giulia , Castagno Emanuele , Ricceri Fulvio , Pagliero Rosaura , Urbino Antonio F 
Published: December 2017

Aim To determine the red flags for serious organic causes of headache in children, to analyze if the management of headache in the Pediatric Emergency Department is appropriate, and whether the follow-up may limit repeated visits to the Emergency Department. Methods All the patients ≤ 18 years referred to our pediatric Emergency Department for non-traumatic headache over 5 years were retrospectively reviewed. The patients followed up by the Pediatric Headache Centre were also screened. Statistical analysis was undertaken using the Chi-squared test or Fisher’s exact test and multivariate analysis; significance at p < 0.05. Results 1833 patients (54.6% males) accessed our Emergency Department 2086 times; 62.1% had primary headache, 30.0% had secondary headache, 7.8% received inconsistent diagnosis. Among those with secondary headache, 24 (1.1% of total visits) were diagnosed with serious disorders. The clinical red flags for “serious headache” were: Cranial nerves palsy, strabismus, and drowsiness. One hundred and eighty four patients (8.8 %) underwent neuroimaging (rate of pathological findings: 7.1 %); 37.2 % of the patients received analgesic therapy. One hundred and fifteen patients (6.2 %) returned within three months; 24 of these were referred to the Headache Centre, with only one accessing the Emergency Department again. Conclusions The vast majority of headaches referred to the Pediatric Emergency Department are benign, and primary forms prevail. “Serious headache” is rare and shows typical clinical features and abnormal neurologic evaluation; specific clinical red flags, along with suggestive personal history, should lead the pediatrician to prescribe only appropriate neuroimaging. Pain relief is still insufficient in the Pediatric Emergency Department despite appropriate guidelines. Last, the collaboration with the Headache Centre is crucial to limit repeated visits.
Combined Popliteal Catheter With Single-Injection vs Continuous-Infusion Saphenous Nerve Block for Foot and Ankle Surgery
Authors: Jarrell Kathleen , McDonald Elizabeth , Shakked Rachel , Nicholson Kristen , Kasper Vincent , Raikin Steven M. 
Published: December 2017

Background: The increasing scope and complexity of foot and ankle procedures performed in an outpatient setting require more intensive perioperative analgesia. Regional anesthesia (popliteal and saphenous nerve blocks) has been proven to provide satisfactory pain management, decreased postoperative opioid use, and earlier patient discharge. This can be further augmented with the placement of a continuous-flow catheter, typically inserted into the popliteal nerve region. This study investigated the use of a combined popliteal and saphenous continuous-flow catheter nerve block compared to a single popliteal catheter and single-injection saphenous nerve block in postoperative pain management after ambulatory foot and ankle surgery. Methods: A prospective study was conducted using 60 patients who underwent foot and ankle surgery performed in an outpatient setting. Demographic data, degree of medial operative involvement, American Society of Anesthesiologists physical classification system, anesthesia time, and postanesthesia care unit time were recorded. Outcome measures included pain satisfaction, numeric pain scores (NPS) at rest and with activity, and opioid intake. Patients were also classified by degree of saphenous nerve involvement in the operative procedure, by the surgeon who was blinded to the anesthesia randomization. Results: Patients in the dual-catheter group took significantly less opioid medication on the day of surgery and postoperative day 1 (POD 1) compared to the single-catheter group ( P = .02). The dual-catheter group reported significantly greater satisfaction with pain at POD 1 and POD 3 and a significantly lower NPS at POD 1, 2, and 3. This trend was observed in all 3 subgroups of medial operative involvement. Conclusion: Patients in the single-catheter group reported more pain, less satisfaction with pain control, and increased opioid use on POD 1, suggesting dual-catheter use was superior to single-injection nerve blocks with regard to managing early postoperative pain in outpatient foot and ankle surgery. Level of Evidence: Level II, prospective cohort study.
Correlation of Incisura Anatomy With Syndesmotic Malreduction
Authors: Boszczyk Andrzej , Kwapisz Sławomir , Krümmel Martin , Grass Rene , Rammelt Stefan 
Published: December 2017

Background: The anatomy of the syndesmosis is variable, yet little is known on the correlation between differences in anatomy and syndesmosis reduction results. The aim of this study was to analyze the correlation between syndesmotic anatomy and the modes of syndesmotic malreduction. Methods: Bilateral postreduction ankle computed tomography (CT) scans of 72 patients treated for fractures with syndesmotic disruption were analyzed. Incisura depth, fibular engagement into the incisura, and incisura rotation were correlated with degree of syndesmotic malreduction in coronal and sagittal planes as well as rotational malreduction. Results: Clinically relevant malreduction in the coronal plane, sagittal plane, and rotation affected 8.3%, 27.8%, and 19.4% of syndesmoses, respectively. The syndesmoses with a deep incisura and the fibula not engaged into the tibial incisura were at risk of overcompression, anteverted incisuras at risk of anterior fibular translation, and retroverted incisuras at risk of posterior fibular translation. Conclusions: Certain morphologic configurations of the tibial incisura increased the risk of specific syndesmotic malreduction patterns. Level of Evidence: Level III, comparative study.
Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins
Authors: Fercher Christian , Keshvari Sahar , McGuckin Michael A , Barnard Ross T 
Published: December 2017

Immunocytokines are fusion proteins that combine the specific antigen binding capacities of an antibody or derivative thereof and the potent bioactivity of a cytokine partner. These novel biopharmaceuticals have been directed to various targets of oncological as well as non-oncological origin and a handful of promising constructs are currently advancing in the clinical trial pipeline. Several factors such as the choice of a disease specific antigen, the antibody format and the modulatory nature of the payload are crucial, not only for therapeutic efficacy and safety but also for the commercial success of such a product. In this review, we provide an overview of the basic principles and obstacles in immunocytokine design with a specific focus on single chain antibody fragment-based constructs that employ interleukins as the immunoactive component.Impact statementSelective activation of the immune system in a variety of malignancies represents an attractive approach when existing strategies have failed to provide adequate treatment options. Immunocytokines as a novel class of bifunctional protein therapeutics have emerged recently and generated promising results in preclinical and clinical studies. In order to harness their full potential, multiple different aspects have to be taken into consideration. Several key points of these fusion constructs are discussed here and should provide an outline for the development of novel products based on an overview of selected formats.
Accessibility of online self-management support websites for people with osteoarthritis: A text content analysis
Authors: Chapman Lara , Brooks Charlotte , Lawson Jem , Russell Cynthia , Adams Jo 
Published: December 2017

Objectives This study assessed accessibility of online self-management support webpages for people with osteoarthritis by considering readability of text and inclusion of images and videos. Methods Eight key search terms developed and agreed with patient and public involvement representatives were entered into the Google search engine. Webpages from the first page of Google search results were identified. Readability of webpage text was assessed using two standardised readability indexes, and the number of images and videos included on each webpage was recorded. Results Forty-nine webpages met the inclusion criteria and were assessed. Only five of the webpages met the recommended reading level for health education literature. Almost half (44.9%) of webpages did not include any informative images to support written information. A minority of the webpages (6.12%) included relevant videos. Discussion Information provided on health webpages aiming to support patients to self-manage osteoarthritis may not be read, understood or used effectively by many people accessing it. Recommendations include using accessible language in health information, supplementing written information with visual resources and reviewing content and readability in collaboration with patient and public involvement representatives.
Understanding violence when the perpetrator has an intellectual disability: The perceptions of professionals
Authors: Lovell Andrew , Skellern Joanne 
Published: December 2017

Aim: The research sought to enhance professional understanding of the violence perpetrated by some people with an intellectual disability. Background: The violent behaviour exhibited by some people with intellectual disabilities remains poorly understood, particularly with regard to a clear and informative definition. Design: A qualitative study investigated the views and perceptions of professionals working directly with people with an intellectual disability in different settings. Methods: Twenty-two semi-structured interviews were undertaken with professionals from a variety of backgrounds, and four themes were generated through data analysis. Findings: Themes produced comprised the degree of intellectual disability, impulsivity, intentionality and unpredictability. Findings indicated tension between understanding violence as purposeful and explaining it in relation to the intellectual disability and/or additional conditions. Conclusion: Intellectual disability is central to understanding the impact of the other three themes, though there is a professional reluctance to use such knowledge as evidence to inform practice.
Apoptosis in megakaryocytes and platelets: the life and death of a lineage
Authors: McArthur Kate , Chappaz Stephane , Kile Benjamin T. 
Published: December 2017

AbstractDespite their profoundly different cellular composition, size, and function, megakaryocytes and platelets both depend on restraint of the intrinsic (or “mitochondrial”) apoptosis pathway by BCL-2 family prosurvival proteins for their development and viability. Activation of the pathway contributes to the clearance of megakaryocytes following platelet shedding and constrains platelet lifespan in the circulation. Important questions remain as to how apoptosis is initiated in these cells at steady state and in response to pathophysiological insults.
Draft genome sequence of Acidithiobacillus thiooxidans CLST isolated from the acidic hypersaline Gorbea salt flat in northern Chile
Authors: Quatrini Raquel , Escudero Lorena V. , Moya-Beltrán Ana , Galleguillos Pedro A. , Issotta Francisco , Acosta Mauricio , Cárdenas Juan Pablo , Nuñez Harold , Salinas Karina , Holmes David S. , Demergasso Cecilia 
Published: December 2017

Abstract
Acidithiobacillus thiooxidans
CLST is an extremely acidophilic gamma-proteobacteria that was isolated from the Gorbea salt flat, an acidic hypersaline environment in northern Chile. This kind of environment is considered a terrestrial analog of ancient Martian terrains and a source of new material for biotechnological applications.
A. thiooxidans
plays a key role in industrial bioleaching; it has the capacity of generating and maintaining acidic conditions by producing sulfuric acid and it can also remove sulfur layers from the surface of minerals, which are detrimental for their dissolution. CLST is a strain of
A. thiooxidans
able to tolerate moderate chloride concentrations (up to 15 g L−1 Cl−), a feature that is quite unusual in extreme acidophilic microorganisms. Basic microbiological features and genomic properties of this biotechnologically relevant strain are described in this work. The 3,974,949 bp draft genome is arranged into 40 scaffolds of 389 contigs containing 3866 protein-coding genes and 75 RNAs encoding genes. This is the first draft genome of a halotolerant
A. thiooxidans
strain. The release of the genome sequence of this strain improves representation of these extreme acidophilic Gram negative bacteria in public databases and strengthens the framework for further investigation of the physiological diversity and ecological function of
A. thiooxidans
populations.
Philanthropic Campaigns and Customer Behavior: Field Experiments on an Online Taxi Booking Platform
Authors: Singh Jasjit , Teng Nina , Netessine Serguei 
Published: December 2017

Firms commonly undertake philanthropic campaigns as a means of attracting and retaining customers. Such campaigns often take the form of charity-linked promotions, whereby a firm donates a specific amount to a charitable cause when a customer takes up the promotion through a related purchase. We carried out three field experiments to study such promotions in the context of an online taxi-booking platform. Customers were randomly assigned to different treatment groups, which received either a charity-linked or a discount-based promotion from a range of monetary amounts. Take-up rates for charity-linked promotions were not only much smaller than for discount-based promotions but also less sensitive to the exact amount involved, consistent with a view that the decision to take up a charity-linked promotion was driven in part by a “warm glow” from mere association with giving. We also find a selection effect in promotion take-up: charity-linked promotions were disproportionately taken up by people who had already been more active customers. Although a promotion take-up does seem to represent new demand rather than mere substitution of a booking that would have occurred anyway, longitudinal data analysis reveals little evidence of a lasting treatment effect on long-term demand beyond the promotion period for either kind of promotion. Given the high cost relative to benefit for the promotional bookings themselves, this finding raises concerns regarding the prevalent practice of firms devoting significant funds for short-term promotions without rigorously examining their exact impact.The online appendix is available at https://doi.org/10.1287/mnsc.2017.2887 .This paper was accepted by Uri Gneezy, behavioral economics.
Bollywoodization or ghettoization? The Bangladeshi dream factory is in disarray
Authors: Rahman Harisur 
Published: December 2017

Abstract
In this article, I claim that instead of making Bangladeshi films appealing to the Bangladeshi middle-class audience, the hegemony of Bollywood films has ghettoized them. I explain that with the change in the target audience and the production and exhibition of Bollywood films in the 1990s, the Bangladeshi middle-class audience responded to this change – as did the Indian middle-class audience – and was alienated from Bangladeshi commercial films. The absence of middle-class audiences in Bangladeshi cinema halls, however, was quickly filled out by working-class audiences who migrated from rural areas following economic liberalization and the expansion of the ready-made garment, housing and transport industries from the 1990s onwards. Bangladeshi commercial filmmakers then targeted the so-called captive lower-class audience with action-packed vulgar or obscene films. Through analysing the titles of Bangladeshi commercial films produced in the 1990s and the 2000s, I expound on how these films were ghettoized, completely alienating the middle-class audience.
Reading the Indian Cinematograph Committee Sessions (1926–28) for film culture in 1920s Burma – with a special focus on Burmese film production
Authors: Bhaumik Kaushik 
Published: December 2017

Abstract
This article is based on a survey of the evidence presented at the proceedings of the Indian Cinematograph Committee (ICC) sessions held in Burma in early 1928 to cull out a synoptic picture of Burmese film culture in the decade of its coming of age: the 1920s. The evidence collated at the ICC sessions remains to date the single largest source for the subject. The Cinematograph Committee was set up by the British colonial state to investigate the conditions of cinema in the Indian subcontinent, with the aim of testing the waters for market possibilities for British films and the entry of British capital into film production in India. The evidence presents us with a vivid picture of the growth of film exhibition in Burma that included Burmese films as well as imported western, Chinese and Indian films, and catered to audiences across viewing niches. The evidence also elucidates the formation of Burmese film studios – their financing, their modes of production and the kinds of films they produced.
Embalming the obscure: The rise of B-movie cinephilia
Authors: Subba Vibhushan 
Published: December 2017

Abstract
This article seeks to investigate B-movie cinephilia during the current ‘B-moment’, when a wave of cinephiliac B-movie desire has erupted across social media platforms. Today, a vibrant community of B-movie cinephiles operates within the folds of the Internet. Born largely within the networked environment of the Internet, this cinephilia has revived the forgotten history and aesthetic of B-movies and horror and sexploitation films that sit at the bottom of the cinematic ecology in India. From being ridiculed and denigrated as trash, these films are now openly celebrated on Internet forums, movie blogs, YouTube channels and Facebook and Twitter pages. It is this activity that I propose to track by investigating the creation, nature and evolution of this cinephilia.
Los newsgames como estrategia narrativa en el periodismo transmedia: propuesta de un modelo de análisis
Authors: García-Ortega Alba , García-Avilés José-Alberto 
Published: December 2017

El creciente uso y popularidad de las narrativas transmedia ha propiciado la aparición de nuevos géneros y formatos periodísticos. Es el caso de los newsgames, un formato interactivo que bebe del videojuego y el periodismo para mostrar las noticias de una forma lúdica, inmersiva y participativa. La presente comunicación tiene como objetivo proponer una herramienta de análisis que permita medir de forma cuantitativa el componente periodístico y lúdico de cualquier newsgame o videojuego periodístico. De este modo, se pretende determinar si predomina la información periodística o la jugabilidad del contenido. La propuesta metodológica aúna en una única ficha de análisis los criterios de calidad del relato periodístico, así como los elementos propios del diseño de videojuegos. Finalmente, se pondrá a prueba su eficacia mediante el estudio de caso de El bueno, el malo y el tesorero, un videojuego periodístico elaborado por El Confidencial Lab y Journalism++ que forma parte de un proyecto transmedia sobre la corrupción a nivel europeo.