bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human resource management and ethical challenges: building a culture for organization success
Authors: Smith Sarah Sanders , Rohr Samuel L. , Panton Richard N. 
Published: January 2018

PurposeHuman resource professionals (HRPs) remain challenged by ethical conundrums in the workplace. Business leaders are asked to respond to demands for efficiency in an environment of distrust or skepticism amongst employees and customers. HRPs who understand ethical decision-making as well as ethical perspectives and implications of actions within the organization can create value within their organizations. The purpose of this paper is to discuss the five ethical content issues of Hosmer’s (1987) model related to the twenty-first century human resource management (HRM) themes.Design/methodology/approachAs a result of a syntheses of leadership and HRM philosophies over several decades, six propositions associated with the content issues are suggested.FindingsHRPs are well-positioned to encourage ethical and moral decision-making within their organizations when they are able to contribute to creation of a culture that honors duties to stakeholders and supports organizational success.Originality/valueThe existence of synthesized analysis regarding organizational leaders, human resource managers, ethics and culture to build organizational success is limited. Thus, this paper highlights a need for organizations and for HRPs to dedicate policies and implement practices which can support ethical sustenance in today’s organizations.
Loyalty membership for luxury hotels in Malaysia
Authors: Hassan Hasliza , Pourabedin Zahra , Sade Abu Bakar , Chai Jiayi 
Published: January 2018

Purpose
Loyalty membership is widely used as a marketing strategy to secure customer’s loyalty in many business sectors. The purpose of this paper is to focus on loyalty membership of customer in Malaysian luxury hotels, specifically, in the capital city of Kuala Lumpur, Malaysia by looking into the perceived value of economic, interaction and psychological needs.

Design/methodology/approach
Quantitative cross-sectional research was conducted to explore the feedback from customers who have loyalty membership with a luxury hotel. Surveyed data of 489 respondents were analysed using confirmatory factor analysis and structural equation modelling.

Findings
There is a significant positive relationship between the psychological needs and perceived value. The relationship between the perceived value and customer’s loyalty is also significant and positive. However, there is no significant relationship between the economic value and the interaction constructs with the perceived value. The perceived value functions as a mediator for the economic value, interaction and psychological needs in respect of customer’s loyalty.

Practical implications
Hotel management should prioritise addressing the elements of psychological needs to enhance the perceived value from the customers’ perspective. The strength of the perceived value indirectly stimulates customer’s loyalty to a hotel, followed by the interaction and economic value from the customer value perspective to ensure customer’s loyalty.

Originality/value
This research highlights on how customers can be secured by a luxury hotel chain through a loyalty membership strategy. The knowledge generated from this research is expected to provide insights to practitioners on how to enhance their loyalty membership marketing strategy.
The effects of value appropriation strategies in channels on intangible firm value
Authors: Kang Jun , Brashear-Alejandro Thomas , Asare Anthony K. , Chen Sixing 
Published: January 2018

PurposeThis study aims to examine the role of channel strategies in value appropriation and their effects on firm value with the consideration of situational factors.Design/methodology/approachAn empirical study with secondary data is conducted in the context of public franchised channels. The authors use Entrepreneur Franchise Top 500 (2012) as the sampling frame and merge the data from three sources to create the final data set. A set of models are built to test the hypotheses in a hierarchical manner.FindingsValue appropriation provides a solid rationale to link marketing channel strategies to firm value. Channel integration is an effective strategy driving intangible firm value. The influence of channel compression on intangible firm value depends on its interaction with other marketing environmental variables.Research limitations/implicationsFirst, the sample size in this study is relatively small though these samples show high representativeness. Second, the empirical analysis in this study focuses on the franchised channels because of data availability.Practical implicationsManagers should consider the role of value appropriation when developing new channel strategies. A channel strategy deserves firm-level attention and resources because of its relevance to firm value. Managers should examine channel environment carefully and deploy internal resources to augment the potential of value appropriation strategies in channels.Originality/valueThis study is among the first to investigate the value relevance of marketing channel strategies from a value appropriation perspective. It identifies profit appropriation and resource appropriation as two mechanisms of value appropriation in marketing channels and uses these two processes to link channel integration and channel compression strategies with firm value.
Microfinance, gender and entrepreneurial behaviour of families in Ghana
Authors: Acheampong George 
Published: January 2018

Purpose
The purpose of this paper is to understand the relationship between microfinance participation and entrepreneurial behaviour of Ghanaian families as well as the moderating role of the family head’s gender. It is argued from a resource-based theory perspective that microfinance is a financial resource that removes credit constraints to entrepreneurial behaviour of families. However, gender of the family head creates heterogeneity in this relationship in line with the gender theory.

Design/methodology/approach
In order to test these claims, cross-sectional data from 2,727 families on microfinance participation and household characteristics in Ghana are utilised.

Findings
The study finds that microfinance participation has a positive and significant relationship with a family’s decision to own an enterprise. Also, the study finds that female-headed families are better utilizers of microfinancial resources for entrepreneurial purposes compared to their male counterparts. This difference is a pure gender effect.

Originality/value
This finding is in contrast to the dominant stream of gender-based entrepreneurship research that suggests that women are subordinate to men and need to be helped to become “honorary men”. From a policy standpoint, solutions aimed at reversing discrimination against women in economic markets must consider women within their own right. The study makes a contribution to the literature by showing empirically the source of heterogeneity in entrepreneurial returns to microfinance participation by families.
Drivers of stakeholders’ view of internal audit effectiveness
Authors: Erasmus Lourens , Coetzee Philna 
Published: January 2018

Purpose
The purpose of this study is to determine the differences in perception of the key stakeholders on the drivers of internal audit effectiveness, namely, senior management and the audit committee, in relation to identified measures. To be seen as an effective internal audit function, value needs to be added for both these stakeholders. It is thus important for internal auditing to obtain an understanding of what these stakeholders respectively perceive as the most prominent drivers of internal audit effectiveness.

Design/methodology/approach
Heads of internal audit functions (providing insight into the drivers), chairpersons of audit committees and senior management (providing insight into the measures) within the South African public sector responded to a survey. The data were subjected to an exploratory factor analysis and principal component analysis to reduce the set of items and to provide continuous scores for use in a multivariate multiple regression analyses.

Findings
Senior management and the audit committee differ in their level or order of prominence of the identified drivers that influence the identified measures of internal audit effectiveness. No statistical similarities in their level of views could be found.

Originality/value
To enhance the effectiveness of internal auditing, the internal audit functions should take cognisance of the difference in perceptions of its key stakeholders on the drivers of internal audit effectiveness, in relation to identified measures, to manage these relationships. No previous research could find that statistically compared views of senior management and the audit committee regarding the drivers of internal audit effectiveness.
Protective efficacy of a DNA vaccine encoding capsid protein of porcine circovirus‐like virus P1 against porcine circovirus 2 in mice
Authors: Zhang Dan , He Kongwang , Wen Libin , Fan Hongjie 
Published: January 2018

ABSTRACTThe capsid protein is the major immunogenic protein of porcine circovirus 2 (PCV2). The nucleotide sequence of porcine circovirus‐like virus P1 shares high homology with open reading frame (ORF) 2 of PCV2, and ORF1 of P1 encodes its structural protein. Mice were vaccinated twice intramuscularly with a plasmid expressing the P1 ORF1 protein (pcDNA3.1(+)‐ORF1) at 2‐week intervals. All animals vaccinated with pcDNA3.1(+)‐ORF1 developed higher specific anti‐P1 antibody levels, and had less PCV2 viremia and milder histopathological changes than PCV2‐challenged mice in the control group. Our results show that the P1 DNA vaccine elicited immune responses against PCV2 infection in a mouse model.
Three‐dimensional receiver deghosting of seismic streamer data using L1 inversion and redundant extended radon dictionary
Authors: Sun Yimin , Verschuur Eric 
Published: January 2018

ABSTRACTIn this paper, we propose a novel three‐dimensional receiver deghosting algorithm that is capable of deghosting both horizontal and slanted streamer data in a theoretically consistent manner. Our algorithm honours wave propagation phenomena in a true three‐dimensional sense and frames the three‐dimensional receiver deghosting problem as a Lasso problem. The ultimate goal is to minimise the mismatch between the actual measurements and the simulated wavefield with an L1 constraint applied in the extended Radon space to handle the underdetermined nature of this problem. We successfully demonstrate our algorithm on a modified three‐dimensional EAGE/SEG Overthrust model and a Red Sea marine dataset.
Elderly patients with suspected chronic digoxin toxicity: A comparison of clinical characteristics of patients receiving and not receiving digoxin‐Fab
Authors: Arbabian Hooman , Lee Hwee Min , Graudins Andis 
Published: January 2018

AbstractObjectiveThe aim of the present study was to compare clinical features of patients with elevated serum digoxin concentrations who were treated with digoxin‐Fab with those where the immunotherapy was not given by a tertiary hospital toxicology service.MethodsThis was a retrospective series of patients with supratherapeutic serum digoxin concentrations referred to the toxicology service from August 2013 to October 2015. Data collected included demographics, presenting complaint, digoxin dose, other medications taken, serum digoxin, potassium and creatinine concentration on presentation and initial and post‐digoxin‐Fab heart rate.ResultsThere were 47 referrals. Digoxin‐Fab was administered in 21 cases. It was given more commonly when the heart rate was <51/min or serum potassium was >5.0 mmol/L. Patients receiving digoxin‐Fab were more likely to be on maintenance therapy with beta‐blockers or calcium channel blockers (95% vs 61%; OR 13.1; 95% CI 1.5–113) and/or potassium‐sparing medications (95% vs 54%; OR 17.1; 95% CI 2.0–147). They had elevated serum creatinine (76% vs 42%; OR 8.2; 95% CI 1.9–34), higher serum potassium (median: 5.1 mmol/L vs 4.2 mmol/L, P = 0.02), higher serum digoxin concentration (median: 3.5 nmol/L vs 2.3 nmol/L, P = 0.02) and pretreatment heart rate <51/min (66% vs 31%; OR 4.5; 95% CI 1.3–15). There were no patients with ventricular arrhythmias or hypotension. Median heart rate increased by 10/min 1 and 4 h after digoxin‐Fab. However, individual heart rate response to digoxin‐Fab was variable.ConclusionDigoxin‐Fab was more commonly administered when heart rate was <51/min. It had a small effect on increasing heart rate; however, individual response to digoxin‐Fab was variable as patients were using other negative chronotropic medications. In symptomatic bradycardic patients on multiple heart failure medications, positive chronotropic and potassium‐lowering therapies should be considered in concert with digoxin‐Fab.
Rapid and safe discharge from the emergency department: A single troponin to exclude acute myocardial infarction
Authors: Brichko Lisa , Schneider Hans G , Chan William , Seah Jarrel , Smit De Villiers , Dart Anthony , Stevens Jeremy P , Mitra Biswadev 
Published: January 2018

AbstractObjectiveTo determine variables that could facilitate safe discharge from the ED following a single high‐sensitivity troponin I (HsTnI) result to exclude acute myocardial infarction (AMI).MethodsA retrospective cohort study was performed at a tertiary hospital of all patients that had serial HsTnI performed within 12 h of arrival to the ED over a 3 year period. The primary exposure variable of interest was a very low troponin initial result (HsTnI <5 ng/L). Medical record review and risk stratification score calculations were undertaken for all patients with the exposure variable of interest and an abnormal second troponin measurement (HsTnI ≥16 ng/L in women and HsTnI ≥26 ng/L in men).ResultsThere were 11 970 patients who presented between 1 July 2013 and 30 June 2016 that had serial HsTnI measurements performed. Of these, 4172 (34.9%) patients had an initial HsTnI measurement <5 ng/L. Of the patients with an initial HsTnI <5 ng/L that met inclusion criteria, 56 (1.3%) had a second troponin result above the 99th percentile and 32 (0.8%) cases of non‐ST elevation myocardial infarction were diagnosed as well as 15 (0.4%) cases of ST elevation myocardial infarction. There were 44 (93.6%) of all AMI cases that met criteria for high‐risk presentations under the National Heart Foundation of Australia guidelines. The negative predictive value of an initial HsTnI <5 ng/L to exclude AMI was 98.9% (95% confidence interval 98.5–99.1).ConclusionsThis supports the utilisation of a rapid rule out strategy to exclude AMI for patients that have an initial HsTnI measurement <5 ng/L in conjunction with a robust risk assessment.
CRISPR disruption of TCTP gene impaired normal development in the silkworm Bombyx mori
Authors: Liu Zu‐Lian , Xu Jun , Ling Lin , Zhang Ru , Shang Peng , Huang Yong‐Ping 
Published: January 2018

AbstractThe translationally controlled tumor protein (TCTP) is a highly conserved and multifunctional protein with activities ranging from cytoskeletal regulation to transcription regulation in numerous organisms. In insects, TCTP is essential for cell growth and proliferation. Recently, TCTP has been reported to affect the innate intestinal immune pathway in the Bombyx mori silkworm, a lepidopteran model insect. However, the comprehensive physiological roles of TCTP in the silkworm remain poorly understood. Here, we performed functional analysis of BmTCTP by using a binary transgenic CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/RNA‐guided CRISPER‐associated protein 9 nucleases) system. Disruption of BmTCTP led to developmental arrestment and subsequent lethality in third instar larvae. Histological analysis revealed that growth impairment originated from decreased cell size, and the proliferation and differentiation of intestinal epithelial cells were also affected. RNA‐seq analysis revealed that genes involved in carbohydrate metabolism, lipid metabolism and digestive system pathways were significantly affected by BmTCTP depletion. Together, the results demonstrated that BmTCTP plays a key role in controlling larval growth and development.
Validation of Modelflow Estimates of Cardiac Output in Hemodialysis Patients
Authors: MacEwen Clare , Sutherland Sheera , Daly Jonathan , Pugh Christopher , Tarassenko Lionel 
Published: January 2018

AbstractVolume‐clamp technology (e.g. Finometer) has become a popular method of collecting continuous, non‐invasive, hemodynamic information during hemodialysis. There is minimal data validating the technique in this patient group. A gold standard cardiac output measurement can be obtained using ultrasound dilution in patients with arterio‐venous fistulae. Continuous cardiac output was measured in 124 hemodialysis sessions in 27 patients using a volume‐clamp device (Finometer PRO). Ultrasound dilution measurement was first taken at baseline (Transonic HD03), then used to calibrate the Finometer. Ultrasound dilution measurement was repeated 2 h into hemodialysis to assess drift following calibration. Pearson’s correlation and Bland–Altman statistics, modified for repeated measures, were used to assess agreement between methods. Linear mixed models were constructed to identify factors that could explain session‐level and patient‐level variation in agreement. For baseline cardiac output before calibration, agreement between volume‐clamp and ultrasound dilution measurements was poor, at 25 ± 75% (correlation 0.26, P < 0.001). There was significant variation in agreement between patients, with age, peripheral vascular disease and hemodialysis vintage contributing to poorer agreement. For cardiac output 2 h after calibration, agreement was −5.2 ± 57.5% (correlation 0.6, P < 0.001). Dynamic changes in blood pressure and fluid balance during hemodialysis resulted in greater drift over time after calibration. There was a large error, both random and systematic, in volume‐clamp estimates of absolute, pre‐calibration cardiac output in this prevalent hemodialysis population. There was minimal bias and reasonable correlation for cardiac output 2 h post‐calibration, but limits of agreement remained too wide to meet current clinical standards.
Sleep quality and functional gastrointestinal disorders. A psychological issue
Authors: Bouchoucha Michel , Mary Florence , Bon Cyriaque , Bejou Bakhtiar , Airinei Gheorghe , Benamouzig Robert 
Published: January 2018

OBJECTIVESleep disorders are often associated with functional gastrointestinal disorders (FGIDs). This study aims to evaluate the association of sleep disorders with specific FGIDs and to assess the related importance of psychological disorders.METHODSWe included 1009 consecutive patients with FGIDs (70.9% females). The patients completed a Rome III questionnaire and after a psychological evaluation on anxiety and depression they were classified according to their sleep disorders using a 7‐point grading scale: Groups 1–3, drowsiness (severe, moderate, mild); Group 4, no change; Groups 5–7, insomnia (mild, moderate, severe). Multinomial logistic regression using sleep group as a dependent variable with no sleep change as reference and body mass index, FGIDs, anxiety and depression as independent variables were used for statistical analysis.RESULTSAltogether 667 (66.1%) patients reported changes in sleep disorders, of whom 487 (48.3%) had decreased sleep and 180 (17.8%) had increased sleep while 342 (33.9%) reported no change. Depression was lower in patients with no change in sleep pattern and increased with the severity of their sleep disorder (P < 0.001). State‐anxiety is associated with moderate drowsiness (P = 0.024), while trait anxiety is associated with mild insomnia (P = 0.048). FGIDs associated with sleep disorders included chest pain, epigastric pain syndrome, irritable bowel syndrome with constipation, diarrhea, bloating, fecal incontinence and proctalgia fugax.CONCLUSIONSleep disorders are associated with FGIDs, especially in the presence of depressive symptoms.
A propensity score‐matched comparison of biodegradable polymer vs second‐generation durable polymer drug‐eluting stents in a real‐world population
Authors: Zhao Ying Jiao , Teng Monica , Khoo Ai Leng , Ananthakrishna Rajiv , Yeo Tiong Cheng , Lim Boon Peng , Loh Joshua P. , Chan Mark Y. 
Published: January 2018

SummaryAimsThe safety and efficacy of BP‐DES compared to second‐generation DP‐DES remain unclear in the real‐world setting. We compared the clinical outcomes of biodegradable polymer drug‐eluting stents (BP‐DES) with second‐generation durable polymer drug‐eluting stents (DP‐DES) in an all‐comer percutaneous coronary intervention (PCI) registry.Methods/ResultsThe study included a cohort of 1065 patients treated with either BP‐DES or DP‐DES from January 2009 through October 2015. Propensity score matching was performed to account for potential confounders and produced 497 matched pairs of patients. The primary endpoint was target lesion failure (TLF) at one‐year follow‐up. The rates of TLF were comparable between BP‐DES and DP‐DES (8.7% vs 9.1%, P = .823) at 1 year. The rates of stent thrombosis at 30 days (0.4% vs 0.4%, P = 1.00) and 1 year (0.8% vs 0.8%, P = 1.00) did not differ between BP‐DES and DP‐DES. There were no significant differences in other clinical outcomes including target vessel failure (8.9% vs 9.5%, P = .741), in‐stent restenosis (1.8% vs 1.0%, P = .282), and cardiac death (6.4% vs 7.4%, P = .533) at 1 year. Multivariate cox regression analysis showed that the risk of TLF at one‐year did not differ significantly between BP‐DES and DP‐DES (hazard ratio 0.94, P = .763).ConclusionsEfficacy and safety of BP‐DES were not better than DP‐DES at one‐year follow‐up.
Prognosis and distribution of lymph nodes metastases in resectable primary pulmonary lymphoepithelioma‐like carcinoma: A large cohort from a single center
Authors: Yu Xiangyang , Wen Yingsheng , Qin Rongqing , Lin Yongbin , Zhang Xuewen , Wang Weidong , Chen Yongqiang , Zhang Lanjun 
Published: January 2018

BackgroundPrimary pulmonary lymphoepithelioma‐like carcinoma is a rare subtype of lung cancer. Until now, the characteristics of lymph nodes metastases in resectable cases have not yet been reported.MethodsIn this study, a total of 87 consecutive patients with primary pulmonary lymphoepithelioma‐like carcinoma that received surgical treatment were investigated from October 1999 to August 2016. The clinical and radiological data and follow‐up information were extracted from hospital records in detail.ResultsIn a univariate analysis, those patients with an early pathological stage (I–II), low rate of lymph node metastases (<30%) and a low number of positive lymph nodes (<5) showed longer recurrence‐free survival and overall survival (all P < 0.05). However, the early pathological stage was identified as the only factor independently associated with recurrence‐free survival by multivariate analysis (P = 0.038). In a preoperative lymph nodes evaluation, the accuracy and specificity of computed tomography alone were 52.9% (46/87) and 88% (302/343), respectively, and 73.2% of these cases with incorrect nodal staging (30/41) were upstaged. Skipping metastases were more frequent in operated stage N2 cases (71.4%), whereas whether or not those patients showed skipping metastasis did not affect their recurrence‐free survival or overall survival (P > 0.05). The highest metastasis frequencies for specific lobes with primary lymphoepithelioma‐like carcinoma are as follows: #5 left upper lobe (21.4%); #7 left lower lobe (40.7%); #2R (28.6%) and/or #4R (14.3%) right upper lobe; #7 (42.9%) right lower lobe; #7 (28%) and/or superior mediastinal nodes (36%) right middle lobe.ConclusionBased on accurate staging and uncertain survival benefit, complete mediastinal lymph nodes dissection is still required for curative resection.