bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fermented rice bran extract improves dyslipidemia in rodents
Authors: Nurrahma Bira Arumndari , Suryajayanti Mega Febia , Dewi Anggi Laksmita , Khairia Zunamilla , Kusuma Rio Jati , Suyoto Perdana S.T. 
Published: January 2018

Purpose
The study aims to investigate the potency of fermented rice bran extract as anti-hypercholesterolemia product by looking at its effect on lipid profile levels and blood glucose levels in dyslipidemia model rats.

Design/methodology/approach
Rice bran was fermented using Rhizopus oligosporus-contained tempeh mold extracted using distilled water. Twenty-four Sprague Dawley rats were divided into a control group and hypercholesterolemia groups. Hypercholesterolemia, also known as dyslipidemia, was induced with fructose-supplemented high-fat diet. Rats induced with dyslipidemia received three different fermented rice bran extract doses, 0 (negative) 1102.5 mg/kgBW/day (FRBE 1) and 2205 mg/kgBW/day (FRBE 2). Blood was collected before and after four weeks of treatment for lipid profile and blood glucose analysis.

Findings
FRBE 2 had significantly lower total cholesterol (101.6 ± 3.3 vs 187.6 ± 3.7 mg/dL), triglyceride (83.3 ± 2.8 vs 130.7 ± 3.4 mg/dL) and LDL level (27.9 ± 1.7 vs 76.7 ± 1.5 mg/dL) but higher HDL level (64.1 ± 3.0 vs 25.5 ± 1.2 mg/dL) compared to the negative group (p < 0.001). Provision of fermented rice bran showed dose-response relationship in all blood lipid markers.

Originality/value
This study was the first to investigate the effectivity of Rhizopus sp.-fermented rice bran extract to improve glucose and lipid profile.
Authentic leadership and performance: the mediating role of employees’ affective commitment
Authors: Ribeiro Neuza , Gomes Daniel , Kurian Shaji 
Published: January 2018

Purpose
This study aims to examine the relationship between authentic leadership (AL), affective commitment and individual performance. More specifically, this study aims to understand how AL influences employees’ affective commitment, how AL influences individual performance, how affective commitment influences individual performance and how affective commitment mediates the relationship between AL and individual performance.

Design/methodology/approach
In total, 212 Portuguese employees participated in this study. A quantitative methodology was used. Baron and Kenny’s linear regression method and Sobel test were used to test the mediation relationship.

Findings
The results reveal that affective commitment mediates the relationship between AL and employees’ performance. In others words, leaders’ authenticity promotes employees’ affective commitment, which, in turn, increases their individual performance.

Practical implications
This research has practical implications for human resource management in organizations, particularly in selection processes and training of leaders and managers. Practitioners looking to increase employee commitment and performance can do so by augmenting the AL.

Originality/value
This study enriches the knowledge about the relevance of emerging areas such as AL theory and responds to the need to understand underlying mechanisms linking AL with workers’ commitment and performance (i.e. testing the construct’s nomological network).
Adherence of social responsibility management in Brazilian organizations
Authors: Caiado Rodrigo Goyannes Gusmão , Quelhas Osvaldo Luiz Gonçalves , Dias Janice Helena de Oliveira , Domingos Maria de Lurdes Costa , França Sergio Luiz Braga , Meiriño Marcelo Jasmim 
Published: January 2018

PurposeThis paper aims to analyze the adherence of social responsibility management (SRM) in Brazilian organizations and to identify the driving and the resistance forces to implement it.Design/methodology/approachThis article presents a deep literature review on SRM, corporate social responsibility (CSR) and stakeholder management, which aim to support a survey research to define, according to experts, the market perception of adherence of SRM.FindingsThe paper presents evidence that there is adherence on the part of the practices of organizations that adhere to the theoretical foundations of SRM in Brazil. It was found that organizations should seek to improve nine areas to implement SRM and can use each of these areas strategically or all together.Practical implicationsThis study provides an opportunity for employees whose perceptions are aligned based on educational programs and engagement in CSR, and these gains favor the improvement of their own management and the quality of relationships.Social implicationsThe research provides an opportunity to recast actions and the possibility of being recognized by stakeholders as active agents in this process.Originality/valueThis study sheds new light on both SRM and the CSR literature because of its attempt to bridge the theoretical foundations and market practices, which was performed to verify the gaps in corporative SRM process of Brazilian organizations. This study highlights for researchers and practitioners a relevant field of study whose importance is widely recognized but whose results remain scarce and limited.
Corporate responsibility, ethics and accountability
Authors: Odongo Nickson Hebert , Wang Daoping 
Published: January 2018

Purpose
This study aims to ascertain the magnitude to which real corporate responsibility (CR), ethics and accountability practices exist in Kenyan corporations.

Design/methodology/approach
The insights of qualitative and quantitative approaches are investigated through descriptive and exploratory study carried out on 193 Kenyan companies in the corporate sector and 5 focus groups discussions comprising 9 members each.

Findings
The paper divulged that current practices on CR, ethics and accountability are relatively low, as only senior managers underwent training on ethics; accountability was broadly perceived as resources accounting instead of actual accountability; and responsibility is highly skewed toward senior management at the expense of stakeholders and society in which they thrive.

Research limitations/implications
The concept of sustainability has not been emphasized as a dimension of CR, ethics and accountability. Fresh opportunities of inquiry are extended considering this aspect.

Practical implications
This study affirms practices that have a positive effect on corporate stakeholders, communities and environment.

Social implications
This study strives to develop approaches of managing and controlling, ensuring that the welfare of stakeholders and society as a whole is uplifted and sustained.

Originality/value
The conception of CR, ethics and accountability practices signifies a theoretical innovation.
Validation and improvement of the European Customer Satisfaction Index for the Spanish wine sector
Authors: Ajami Miguel Pérez , Navarro Elola Luis , Pastor Jesús 
Published: January 2018

Purpose
A study of the Spanish wine sector, in this case specifically the Designation of Origin (DO) Somontano, requires validation of the European Customer Satisfaction Index (ECSI), which also needs to be improved and adapted to obtain more information on customer satisfaction. The paper aims to discuss this issue.

Design/methodology/approach
In this paper the ECSI model was applied, based on structural equation modeling (SEM) using the partial least squares.

Findings
An empirical analysis shows that the importance of customers’ expectations and perceived quality are the most influential factors in achieving satisfaction. Also highlighted in the new model is the linkage between service and product qualities in a unique variable, total quality.

Originality/value
In addition to validating the ECSI model for DO Somontano, a new innovative implementation was developed and tested to improve the calculation of satisfaction.
The excellence of patient-centered healthcare
Authors: Moretta Tartaglione Andrea , Cavacece Ylenia , Cassia Fabio , Russo Giuseppe 
Published: January 2018

Purpose
Nowadays, international healthcare agendas are focused on patient centeredness. Policies are aimed at improving patient’s satisfaction by enhancing patient empowerment and value co-creation. However, a comprehensive model addressing the relationships between these constructs has not so far been developed. The purpose of this paper is to develop and test a model which explains the effects of patient empowerment and value co-creation on patients’ satisfaction with the quality of the services they experience.

Design/methodology/approach
The links between patient satisfaction, empowerment and value co-creation are theoretically outlined via an in-depth literature review. The resulting model is tested through a survey administered to 186 chronically ill patients. The results are analyzed through covariance-based structural equation modeling.

Findings
The results show that patient empowerment positively influences value co-creation which, in turn, is positively related to patient satisfaction. In addition, the analysis reveals that patient empowerment has no direct effects on satisfaction.

Research limitations/implications
Although the cross-sectional design made it possible to clearly estimate the relationships among variables, it overlooked the longitudinal dimensions of co-creation processes.

Practical implications
The study provides practitioners with suggestions to design patient-centered healthcare services by leveraging on patient knowledge, participation, responsibility in care and involvement in the value-creation process.

Originality/value
Over the last decade, healthcare management literature has shifted its focus from healthcare organizations to patients. The number of contributions about patient satisfaction, empowerment and value co-creation exponentially increased. However, these dimensions are often studied separately. This work advances available knowledge by clarifying and testing the relationships between these three constructs.
Clinical and molecular implications of structural changes to desmosomes and corneodesmosomes
Authors: Ishida‐Yamamoto Akemi , Igawa Satomi , Kishibe Mari , Honma Masaru 
Published: January 2018

AbstractDesmosomes provide the main intercellular adhesive properties between epidermal keratinocytes. Their distribution becomes uneven in severe dermatitis, multiple allergies and metabolic wasting syndrome due to desmoglein 1 deficiency and the loss of intercellular adhesion or acantholysis. When keratinocytes differentiate from granular cells into cornified cells, desmosomes are transformed into corneodesmosomes and can provide stronger intercellular adhesion. Degradation of corneodesmosomes is a tightly regulated process involving a number of proteases and their inhibitors. Peripheral corneodesmosomes are protected from proteolytic degradation by the tight junction‐related structures around them, and this construction provides the basis for the normal basket weave‐like structure of the stratum corneum. In Netherton syndrome, which is caused by an absence of the protease inhibitor lymphoepithelial Kazal‐type‐related inhibitor, premature degradation of corneodesmosomes occurs due to the overactivation of proteases involved in corneodesmosome degradation. Inflammatory peeling skin disease is caused by the absence of corneodesmosin, a unique component of corneodesmosomes. In this disease, corneodesmosomes are structurally abnormal, and their adhesiveness is compromised, which leads to intercellular splitting between the stratum corneum and stratum granulosum. The better we understand desmosome and corneodesmosome ultrastructure in normal and diseased skin, the clearer the physiological and pathological mechanisms of epidermal integrity become.
Reactive oxygen species‐induced parthanatos of immunocytes by human cytomegalovirus‐associated substance
Authors: Kim Jung Heon , Kim Jiyeon , Roh Jin , Park Chan‐Sik , Seoh Ju‐Young , Hwang Eung‐Soo 
Published: January 2018

ABSTRACTPrevious studies have examined various immune evasion strategies of human cytomegalovirus (HCMV) to gain understanding of its pathogenesis. Although the mechanism that underlies immunocyte destruction near HCMV‐infected lesions has yet to be established, it is here shown that substances produced by HCMV‐infected cells induce death in several types of immunocytes, but not in fibroblasts or astrocytomas. These substances contain HCMV proteins and were termed HCMV‐associated insoluble substance (HCMVAIS). The mechanism by which HCMVAIS induces cell death was characterized to improve understanding the death of immunocytes near HCMV‐infected lesions. HCMVAIS were found to trigger production of intracellular nicotinamide adenine dinucleotide phosphate oxidase‐derived reactive oxygen species (ROS), resulting in cell death, this effect being reversed following treatment with ROS inhibitors. Cell death was not induced in splenocytes from NOX‐2 knockout mice. It was hypothesized that DNA damage induced by oxidative stress initiates poly ADP‐ribose polymerase‐1 (PARP‐1)‐mediated cell death, or parthanatos. HCMVAIS‐induced cell death is accompanied by PARP‐1 activation in a caspase‐independent manner, nuclear translocation of apoptosis‐inducing factor (AIF), and DNA fragmentation, which are typical features of parthanatos. Treatment with an AIF inhibitor decreased the rate of HCMVAIS‐induced cell death, this being confirmed by hematoxylin and eosin staining; cell death in most HCMV‐positive foci in serial section samples of a large intestine with HCMV infection was TUNEL‐positive, cleaved caspase 3‐negative and CD45‐positive. Taken together, these data suggest that HCMV inhibits local immune responses via direct killing of immunocytes near HCMV‐infected cells through ROS‐induced parthanatos by HCMVAIS.
Adaptation of Salmonella enterica to bile: essential role of AcrAB‐mediated efflux
Authors: Urdaneta Verónica , Casadesús Josep 
Published: January 2018

SummaryAdaptation to bile is the ability to endure the lethal effects of bile salts after growth on sublethal concentrations. Surveys of adaptation to bile in Salmonella enterica ser. Tyhimurium reveal that active efflux is essential for adaptation while other bacterial functions involved in bile resistance are not. Among S. enterica mutants lacking one or more efflux systems, only strains lacking AcrAB are unable to adapt, thus revealing an essential role for AcrAB. Transcription of the acrAB operon is upregulated in the presence of a sublethal concentration of sodium deoxycholate (DOC) while other efflux loci are either weakly upregulated or irresponsive. Upregulation of acrAB transcription is strong during exponential growth, and weak in stationary cultures. Single cell analysis of ethidium bromide accumulation indicates that DOC‐induced AcrAB‐mediated efflux occurs in both exponential and stationary cultures. Upregulation of acrAB expression may thus be crucial at early stages of adaptation, while sustained AcrAB activity may be sufficient to confer bile resistance in nondividing cells.
Collection of Wet‐Origin Footwear Impressions on Various Surfaces Using an Electrostatic Dust Print Lifter
Authors: Hong Sungwook , Park Miseon 
Published: January 2018

AbstractElectrostatic dust print lift method is known to be able to recover only dry‐origin footwear impression. However, the wet‐origin footwear impression could also be recovered using this method. As the amount of dust accumulated before deposition of the wet‐origin footwear impression increased, the intensity of the footwear impression lifted with this method became stronger. If the footwear impression is not affected by moisture after it is made, the 28‐h old wet‐origin footwear impression could be recovered using this method. The intensity of the lifted footwear impression did not decrease significantly even when the number of sequential steps increased as long as the shoe sole is wet. However, when the moisture on the shoe sole depleted, the intensity of the footwear impression decreased sharply. This method has the advantage of being able to enhance the footwear impression without being affected by the footwear impressions deposited in the past.
Inflammatory back pain and associated disease conditions among patients with chronic low back pain in Bangladesh
Authors: Yesmin Sabrina , Abdal Syed Jamil , Rahman Aminur , Islam Md. Nazrul , Ahammad Alamgir Mustak , Ahmed Shamim , Shahin Md. Abu , Chowdhury Minhaj Rahim , Haq Syed Atiqul 
Published: January 2018

AbstractAimInflammatory back pain (IBP) is the earliest symptom of axial and other forms of spondyloarthritis (SpA). However, there are no published data on prevalence of IBP among patients suffering from chronic low back pain (CLBP) in Bangladesh. In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh.MethodsThis 1 year cross‐sectional study was conducted among 240 CLBP patients in a rheumatology outpatient clinic. Assessment of Spondyloarthritis International Society classification criteria of IBP and predefined recognized classification criteria were followed to define different subtypes of SpA. Means and standard deviations were reported for continuous variables. Descriptive and bi‐variate analyses were accordingly performed.ResultsOf 240 CLBP patients, 60 (25%) had IBP and 180 (75%) had mechanical back pain (MBP). Among the 60 IBP patients, 52 (86.6%) had predominantly axial SpA (axSpA) and eight (13.4%) had predominantly peripheral spondyloarthritis. In the axSpA group, 49 (94.2%) had radiographic axSpA (rd‐axSpA) also known as AS and three (5.8%) had non‐radiographic axSpA (nr‐axspA). AxSpA patients could be divided into eight (15.35%) with psoriasis, two (3.8%) with reactive arthritis and one patient (1.9%) had arthritis associated with inflammatory bowel disease. Fifty (83.3%) IBP and 73 (40.6%) MBP patients had age at onset of back pain < 40 years. Forty‐two (70%) of the IBP and 100 (55.6%) of the MBP patients had normal body mass index. All these differences were statistically significant (P ≤ 0.0001).ConclusionsInflammatory back pain is common among patients presenting with CLBP. The commonest cause of IBP is AS, followed by PsA and nr‐axSpA.
Phacoemulsification and primary implantation with bag‐in‐the‐lens intraocular lens in children with unilateral and bilateral cataract
Authors: Nyström Alf , Almarzouki Nawaf , Magnusson Gunilla , Zetterberg Madeleine 
Published: January 2018

AbstractPurposeTo report outcome in a paediatric cohort with cataract extraction and implantation of bag‐in‐the‐lens intraocular lens (BIL‐IOL).MethodsChildren younger than 16 years of age subjected to phacoemulsification with primary implantation of BIL‐IOL during 2009 through 2013 were analysed retrospectively. Exclusion criteria were uveitis or ≤6 months of follow‐up.ResultsIn total, 109 eyes of 84 children were included; 40 unilateral and 44 bilateral cataracts. For all eyes, median age at surgery was 2.5 years (range 2 weeks to 14.1 years) and 16 children (24 eyes) were ≤6 weeks. Coexisting systemic disease was more common in children with bilateral cataract (24 patients, 54.5%) compared to unilateral cataract (6 patients, 15.0%, p < 0.0001). Ocular comorbidity was more common in unilateral cataracts; n = 14 eyes (35.0%) compared to bilateral cataracts; n = 10 eyes (14.5%; p = 0.017). Median follow‐up was 2.8 years (range 7 months to 5.8 years). During the follow‐up period, 15 (13.8%) eyes developed glaucoma and five (4.6%) eyes required treatment for visual axis opacification (VAO). Corrected distance visual acuity (CDVA) for bilateral cataracts at last follow‐up was 0.42 ± 0.45 (logMAR; mean±SD) with 35 (55.6%) eyes attaining a CDVA of ≥0.5 (dec). For unilateral cataracts mean CDVA was significantly poorer; 0.67 ± 0.51 (p = 0.010) with 15 (37.5%) eyes attaining a CDVA of ≥0.5.ConclusionFor children having cataract surgery with primary implantation of BIL‐IOL, VAO is rare and visual outcome overall good. Unilateral cataracts are associated with a higher proportion of ocular comorbidity and poorer visual outcome.
Interferon‐induced protein 35 inhibits endothelial cell proliferation, migration and re‐endothelialization of injured arteries by inhibiting the nuclear factor‐kappa B pathway
Authors: Jian D. , Wang W. , Zhou X. , Jia Z. , Wang J. , Yang M. , Zhao W. , Jiang Z. , Hu X. , Zhu J. 
Published: January 2018

AbstractAimEndothelial recovery, or re‐endothelialization, plays an important role in intimal hyperplasia and atherosclerosis after endothelial injury. Studying the mechanisms of re‐endothelialization and strategies to promote efficient endothelial recovery are still needed. Interferon‐induced protein 35 (IFI35) is an IFN‐γ‐induced protein that plays important roles in the antivirus‐related immune‐inflammatory response. In this study, we tested whether overexpression IFI35 affects the proliferation and migration of endothelial cells (ECs) and re‐endothelialization.MethodsWire injury of the carotid artery was induced in C57BL/6 mice, which was followed by IFI35 or null adenovirus transduction. Evans blue staining and HE staining were performed to evaluate the re‐endothelialization rate and neointima formation. In vitro studies, primary human umbilical vein endothelial cells (HUVECs) were transfected with Ad‐IFI35 or siRNA‐IFI35 to evaluate its potential roles in cell proliferation and migration. Furthermore, the potential mechanism relating inhibition of NF‐κB/p65 pathway was elaborated by luciferase assay and IFI35 domain deletion assay.ResultsIn IFI35 adenovirus‐transduced mice, the re‐endothelialization rates at days 3, 7 were significantly reduced compared to those in null adenovirus‐transduced mice (5% and 35%, vs 20% and 50%, respectively). Meanwhile, subsequent neointimal hyperplasia was obviously increased in IFI35 adenovirus‐transduced mice. In vitro studies further indicated that IFI35 inhibits both EC proliferation and migration by inhibiting the NF‐κB/p65 pathway. Subsequent studies demonstrated that IFI35 functionally interacted with Nmi through its NID1 domain and that knock‐down of Nmi significantly mitigated the inhibitory effect of IFI35 on EC proliferation and migration.ConclusionOur study revealed a novel mechanism through which IFI35 affects the proliferation and migration of ECs as well as neointima formation, specifically through inhibition of the NF‐κB/p65 pathway. Thus, IFI35 is a promising target for the prevention and treatment of post‐injury vascular intimal hyperplasia.