bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación de las características de un sistema de información con base en la norma ISO/IEC 9126-1
Authors: Guío Ávila Henry Alfonso 
Published: February 2016

<p>Con el fin de evaluar la calidad de los sistemas de información aplicados por las organizaciones y buscar su mejoramiento, se han desarrollado normas técnicas internacionales.</p><p>El propósito de este estudio consiste en evaluar las características de calidad de un sistema de información en cuanto a su efectividad, productividad, seguridad y satisfacción, mediante el uso de la norma técnica ISO/IEC 9126-1:2001. La metodología de evaluación<br />se basa en la operación en uso de un sistema de información, según la metodología propuesta por la norma técnica ISO/IEC 9126-4:2004. Como contexto de aplicación para la evaluación se toma el sistema de información académico (SAC) que la Universidad anto Tomás – Seccional Tunja desarrolló en el marco de la construcción de su sistema de gestión de la calidad bajo el modelo ISO 9001:2008. El sistema de información académico SAC tiene un papel preponderante, ya que constituye el eje de los procesos académicos y administrativos de la Universidad.</p><p>Se identifican la conformidad o no del SAC con las características de calidad de software mencionadas anteriormente, así como la relación entre la evaluación y el sistema de gestión de la calidad. La investigación destaca el aporte al cumplimiento de los principios de gestión de la calidad, principalmente en lo referente al enfoque al cliente, la mejora continua y la toma de decisiones basada en hechos.</p>
A Novel Test for Detecting SNP–SNP Interactions in Case-Only Trio Studies
Authors: Balliu Brunilda , Zaitlen Noah 
Published: February 2016

Abstract
Epistasis plays a significant role in the genetic architecture of many complex phenotypes in model organisms. To date, there have been very few interactions replicated in human studies due in part to the multiple-hypothesis burden implicit in genome-wide tests of epistasis. Therefore, it is of paramount importance to develop the most powerful tests possible for detecting interactions. In this work we develop a new SNP–SNP interaction test for use in case-only trio studies called the trio correlation (TC) test. The TC test computes the expected joint distribution of marker pairs in offspring conditional on parental genotypes. This distribution is then incorporated into a standard 1 d.f. correlation test of interaction. We show via extensive simulations under a variety of disease models that our test substantially outperforms existing tests of interaction in case-only trio studies. We also demonstrate a bias in a previous case-only trio interaction test and identify its origin. Finally, we show that a previously proposed permutation scheme in trio studies mitigates the known biases of case-only tests in the presence of population stratification. We conclude that the TC test shows improved power to identify interactions in existing, as well as emerging, trio association studies. The method is publicly available at www.github.com/BrunildaBalliu/TrioEpi.
Kel1p Mediates Yeast Cell Fusion Through a Fus2p- and Cdc42p-Dependent Mechanism
Authors: Smith Jean A , Rose Mark D 
Published: February 2016

Abstract
Cell fusion is ubiquitous among eukaryotes. Although little is known about the molecular mechanism, several proteins required for cell fusion in the yeast Saccharomyces cerevisiae have been identified. Fus2p, a key regulator of cell fusion, localizes to the shmoo tip in a highly regulated manner. C-terminal truncations of Fus2p cause mislocalization and fusion defects, which are suppressed by overexpression of Kel1p, a kelch-domain protein of unknown function previously implicated in cell fusion. We hypothesize that Fus2p mislocalization is caused by auto-inhibition, which is alleviated by Kel1p overexpression. Previous work showed that Fus2p localization is mediated by both Fus1p- and actin-dependent pathways. We show that the C-terminal mutations mainly affect the actin-dependent pathway. Suppression of the Fus2p localization defect by Kel1p is dependent upon Fus1p, showing that suppression does not bypass the normal pathway. Kel1p and a homolog, Kel2p, are required for efficient Fus2p localization, acting through the actin-dependent pathway. Although Kel1p overexpression can weakly suppress the mating defect of a FUS2 deletion, the magnitude of suppression is allele specific. Therefore, Kel1p augments, but does not bypass, Fus2p function. Fus2p mediates cell fusion by binding activated Cdc42p. Although Kel1p overexpression suppresses a Cdc42p mutant that is defective for Fus2p binding, cell fusion remains dependent upon Fus2p. These data suggest that Fus2p, Cdc42p, and Kel1p form a ternary complex, which is stabilized by Kel1p. Supporting this hypothesis, Kel1p interacts with two domains of Fus2p, partially dependent on Cdc42p. We conclude that Kel1p enhances the activity of Fus2p/Cdc42p in cell fusion.
Modele culturale de standardizare lingvistică
Authors: Geeraerts Dirk 
Published: February 2016

În acord cu tendințele din teoria culturală (vezi Burke et al., 2000), lingvistica cognitivă evidențiază faptul că noi înțelegem realitatea socială prin prisma unor modele, „modele culturale” sau „teorii naive (populare)”, și, de la Holland & Quinn (1987) la Lakoff (1996) și Palmer (1998) pînă la Dirven et al. (2001a, 2001b), specialiștii în lingvistică cognitivă au demonstrat că instrumentarul tehnic al lingvisticii cognitive poate fi utilizat pentru a arăta că perspectivele noastre asupra realității sociale sînt modelate pe baza unor de tipare de gîndire. Însă, dacă limba este o realitate socială și culturală, ce modele ne formează concepția despre limbă? Mai exact, care sînt modelele care formează modul nostru de a gîndi despre limbă ca fenomen social? Care sînt paradigmele pe care le folosim pentru a gîndi despre limbă, nu neapărat ca structură lingvistică (așa cum se observă în Reddy 1979), ci ca variație lingvistică, adică modelele despre felul în care varietățile lingvistice sînt răspîndite într-o comunitate lingvistică și maniera prin care această distribuție ar trebui evaluată?
Scopul lucrării de față este de a discuta existența a două modele de bază: cel raționalist și cel romantic. Voi cartografia modalitățile prin care aceste două modele interacționează, voi descrie evoluția lor în curgerea timpului și voi explora modul în care ele pot fi întrebuințate pentru a analiza variația lingvistică actuală.
Tecnologias digitais: reflexões sobre usos e excessos ilustradas pelos quadrinhos de Andre Dahmer
Authors: Cabello Janaina 
Published: February 2016

RESUMO: Este artigo propõe algumas reflexões sobre possíveis atravessamentos/impactos nos processos de subjetivação pela apropriação das tecnologias digitais no século XXI e de como seus usos e (supostos) excessos têm impactado nas constituições subjetivas diante de outras maneiras de o homem mostrar/olhar/sentir/ensinar, que se constituem nas relações estabelecidas na sociedade atual. Sob uma perspectiva histórico-cultural, discute-se sobre as apropriações das tecnologias digitais e as constituições das subjetividades (individuais e num contexto social mais amplo), tendo como pano de fundo as ilustrações do quadrinista brasileiro Andre Dahmer. Essas ilustrações foram escolhidas por fazerem parte da obra do autor que, através das redes sociais, divulga um trabalho que nos provoca e nos convida a pensar sobre como nos relacionamos e, consequentemente, (nos) mostramos, (nos) olhamos, sentimos, ensinamos e aprendemos em subjetividades que são atravessadas, constituídas e reconstituídas pelas apropriações das tecnologias no cenário contemporâneo.PALAVRAS-CHAVE: novas tecnologias; tecnologias digitais; subjetividades; apropriações. ABSTRACT:This paper proposes some reflections about possible crossings/impacts on subjective processes from the appropriation of digital technologies in the twenty-first century and how their uses and (alleged) excesses have impacted on the subjective constitutions facing other ways humans can show/look/feel/teach, that constitutes the established relationships in the network society. From a historical and cultural perspective, we discuss about the appropriation of digital technologies and the constitutions of subjectivity (individual and in a wider social context), with the backdrop of the illustrations of the Brazilian cartoonist Andre Dahmer, who, through social networks, discloses his work, which provokes and invites us to think about how we relate and therefore, we show and look at ourselves, feel, teach and learn in new subjective configurations with are crossed, constituted and reconstituted by the appropriation of technologies in the contemporary scene.KEYWORDS: new technologies; digital technologies; subjectivities; appropriantions.
O mago e a academia: o discurso sobre Paulo Coelho
Authors: Do Prado Priscila Finger 
Published: February 2016

RESUMO:O presente trabalho pretende analisar o discurso sobre Paulo Coelho na Academia Brasileira de Letras. Tendo em vista seu lugar discursivo de autor de best-sellers, percebemos certo desconforto da crítica e da Academia em relação ao autor que, muitas vezes, vê sua obra figurar na estante de “Auto-ajuda”. Partimos da hipótese de que esse discurso apareça de duas formas: a do silenciamento (da crítica) e a da aclamação (do público leitor). Nesse trabalho, contudo, analisaremos o discurso sobre Paulo Coelho que consta no site da Academia, tanto na sua apresentação quanto no seu discurso de posse, analisando possíveis movimentos de sentidos percebidos.PALAVRAS-CHAVE: Paulo Coelho; ABL; discurso sobre. ABSTRACT:This paper analyzes the discourse about Paulo Coelho at the Brazilian Academy of Letters. Given its discursive place of best-selling author, we noticed some discomfort from critics and the Academy towards the author who often sees their work appear on the shelf "Self-help". Our hypothesis is that the discourse on Paulo Coelho appears discursively in two ways: the silencing (critical) and acclaim (the reading public). In this work, however, we analyze the discourse about the author who appears on the Academy site, both in its presentation, and in his inaugural speech, analyzing possible movements of meanings surrounding this discourse.KEYWORDS: Paulo Coelho; ABL; discourse on.
Maltrato infantil: ¿conocer su impacto económico favorece su prevención?
Authors: Loredo-Abdalá Arturo 
Published: February 2016

<p>Una patología que ha existido desde tiempo inmemorial en la humanidad es la violencia que sufren las niñas, niños y adolescentes. En 1989, en la Asamblea General de la Organización de las Naciones Unidas, se dio una atención muy especial a este problema y se enfatizó el interés superior por este grupo etario con el objetivo de evitar que se afecten sus integridades física, emocional, educativa y económica, entre otras.</p><p> </p><p> </p>
Is It Possible To Induce The "Spontaneous Regression" Of Cancer? A Mechanism of Activation for the Innate Immune Response
Authors: Oleksyszyn Jozef 
Published: February 2016

The article deals with a theoretical model Ã‚Â of the mechanism of the spontaneous regression of tumor, involving the activation of innate immune response. After stimulation the cells of the immune system, use glycolysis for ATP synthesis. Ã‚Â Lactic acid, the final product of glycolysis, acts as inhibitor of such activation. Therefore, highly glycolytic cancerous cells form the environment (hypoglycemia with high level of lactic acid), which is strongly inhibitory to immune cells activation. Starvation, KD (ketogenic diet) and ColeyÃ¢â‚¬â„¢s toxin induce hypoglycemia and in the long term should also lower lactic acid level. After a few days of such treatment the glucose level could increase naturally due to gluconeogenesis or by the application of significant dose of glucose. Such procedure should induce activation of immune cells response (high glucose and low lactic acid levels) and a spontaneous regression of cancer. If lactic acid concentration remained still too high and thus inhibit the activation of immune cells, the organism would require alkalization because sodium lactate is not inhibitoryÃ‚Â to the activation of immune cells. The model explains the cases of spontaneous regression described in literature and could be easily verifiedÃ‚Â experimentally.
Assessment of effect of computer tomography with intravenous contrast administration on renal excretory function
Authors: Pietrzak Mikołaj , Cieślar Grzegorz 
Published: February 2016

WstępPomimo opisywanego ryzyka wystąpienia nefropatii kontrastowej definiowanej jako nagłe (do 48–72 h) pogorszenie funkcji nerek po podaniu kontrastu dotychczas nie ustalono wytycznych odnośnie do granicznego poziomu markerów czynności wydalniczej nerek, dla których dopuszczalne jest wykonanie kontrastowego badania TK. Celem pracy była ocena wpływu dożylnego podania kontrastu podczas badań TK różnego typu na zmiany wartości markerów czynności wydalniczej nerek.Materiał i metodyW prospektywnym badaniu analizowano 60 kolejnych pacjentów (25 kobiet i 35 mężczyzn), którym wykonano badanie TK z dożylnym podaniem kontrastu. W dniu badania oraz po 48 godzinach w surowicy pacjentów oznaczano stężenie markerów czynności nerek: kreatyniny, mocznika i potasu oraz obliczano współczynnik filtracji kłębuszkowej (eGFR). Pacjentów podzielono na 2 grupy zależnie od wyjściowych wartości badanych markerów: grupa 1 – wartości prawidłowe, grupa 2 – wartości przekraczające normę średnio o ok. 20%.WynikiŚrednie stężenie kreatyniny przed badaniem nie różniło się znamiennie od stężenia po badaniu (1,05 ± 0,23 vs. 1,03 ± 0,26 mg/dl). Średnia wartość eGFR przed badaniem nie różniła się znamiennie od wartości po badaniu (71,53 ± 18,86 vs. 74,25 ± 22,50 ml/min./1,73 m2). Nie stwierdzono również istotnych zmian stężenia mocznika i potasu po wykonaniu badania. Wartości badanych parametrów po wykonaniu badania TK nie różniły się znamiennie w stosunku do wartości wyjściowych w żadnej grupie chorych, nie były również zależne od płci i rodzaju badania TK.WnioskiDożylne podanie kontrastu w trakcie badania TK nie powoduje znamiennych zmian wartości markerów czynności wydalniczej nerek u pacjentów z prawidłową czynnością nerek oraz u pacjentów z wyjściowymi wartościami markerów przekraczającymi granicę normy o ok. 20%, bez względu na płeć i rodzaj wykonanego badania.
A Mirage or a Rural Life Line? Analysing the impact of Mahatma Gandhi Rural Employment Guarantee Act on Women Beneficiaries of Assam
Authors: Bhattacharyya Rituparna , Vauquline Polly 
Published: February 2016

The National Rural Employment Guarantee Act (NREGA), launched in February 2006 was renamed in October 02, 2009 as the Mahatma Gandhi National Rural Employment Guarantee Act (henceforth, MGNREGA). It is an anti-poverty flagship programme of the Government of India. The key purpose of MGNREGA is to enhance wage employment in the rural areas by providing at least 100 days of guaranteed employment to every household in a financial year.Â The MGNREGA implementation status report for the financial year 2012-2013 unfolds that the programme has already provided employment to 44.9 million households across 28 districts and five union territories. Hence, it is becoming increasingly difficult to ignore the impact of MGNREGA on women beneficiaries. A plethora of research argues that MGNREGA, which promotes inclusive growth, is a vehicle of change, a lifeline for rural women. So far, however, there has been very little discussion about the impact of MGNREGA on women beneficiaries of Assam. This research is an attempt to examine the participation of women in MGNREGA, Assam. It critically looks at the issues, problems and challenges confronted by the women while working at MGNREGA. Written from a feminist perspective on gender, poverty and womenâ€™s empowerment, the research seeks to address the problems of the women beneficiaries through their lived experiences. For this, we conducted in-depth interviews with the women beneficiaries in the months of August and September, 2009 in four remote areas namely, Burka, Chandrapur, Barbhang and Muguriya, the first two situated in Kamrup, while the third and the fourth in Barpeta districts of Assam, where the programme of MGNREGA is on-going. The findings of the research suggest measures so that the programme can be made more effective in the long run.
Removal of Pb(II) and Zn(II) from Aqueous Solutions by Raw Crab Shell: A Comparative Study
Authors: Zhou Chuanqiang , Gong Xiangxiang , Han Jie , Guo Rong 
Published: February 2016

ABSTRACT: Removals of Pb(II) and Zn(II) ions from water using crab (Clistocoeloma sinensis) shell particles as biosorbent have been compared in this study. Uptake equilibriums for two ions well described by Langmuir isotherm revealed that crab shell possessed higher uptake capacity for Pb(II) (709 mg/g) than that for Zn(II) (117 mg/g). Kinetics data for the uptake of the two metals were successfully modeled using the pseudo‐second‐order model, where the initial uptake rate of Pb(II) was much faster than that of Zn(II). Dubinin‐Radushkevick modeling and thermodynamic parameters hinted at different uptake mechanisms of Pb(II) and Zn(II) removal by crab shell, attested by FTIR, XRD, FESEM analysis. Pb(II) ion was removed mainly through the chemical reaction, while the uptake of Zn(II) ion onto crab shell was attributed to the chelation and coordination interactions. The polluted river water and laboratory wastewater both satisfied the standards for drinking and irrigation/fishery water, respectively, after being treated with crab shell particles.
ALPHA-CONSTRAINED QSE NUCLEOSYNTHESIS IN HIGH-ENTROPY AND FAST-EXPANDING MATERIAL
Authors: Fujibayashi Sho , Takashi Yoshida  , Yuichiro Sekiguchi  
Published: February 2016

ABSTRACT
We investigate the nucleosynthesis process in high-entropy (

) and very fast expanding (

) materials. In such a material with the electron fraction near 0.5, an interesting nucleosynthesis process occurs. In this process, the abundance distribution of heavy nuclei of

achieves quasi-statistical equilibrium (QSE) at high temperature and the abundances are frozen at the end of the nucleosynthesis. We explain this abundance distribution using the “alpha-constrained QSE” abundances formulated in this paper. We demonstrate that this nucleosynthesis would occur in neutrino-driven winds from massive proto-neutron stars in hypernovae, where

p-nuclei are synthesized.
PREDICTION OF FORBIDDEN ULTRAVIOLET AND VISIBLE EMISSIONS IN COMET 67P/CHURYUMOV–GERASIMENKO
Authors: Raghuram Susarla , Bhardwaj Anil , Galand Marina 
Published: February 2016

ABSTRACT
Remote observation of spectroscopic emissions is a potential tool for the identification and quantification of various species in comets. The CO Cameron band (to trace CO2) and atomic oxygen emissions (to trace H2O and/or CO2, CO) have been used to probe neutral composition in the cometary coma. Using a coupled-chemistry-emission model, various excitation processes controlling the CO Cameron band and different atomic oxygen and atomic carbon emissions have been modeled in comet 67P/Churyumov–Gerasimenko at 1.29 AU (perihelion) and at 3 AU heliocentric distances, which is being explored by ESA's Rosetta mission. The intensities of the CO Cameron band, atomic oxygen, and atomic carbon emission lines as a function of projected distance are calculated for different CO and CO2 volume mixing ratios relative to water. Contributions of different excitation processes controlling these emissions are quantified. We assess how CO2 and/or CO volume mixing ratios with respect to H2O can be derived based on the observed intensities of the CO Cameron band, atomic oxygen, and atomic carbon emission lines. The results presented in this work serve as baseline calculations to understand the behavior of low out-gassing cometary coma and compare them with the higher gas production rate cases (e.g., comet Halley). Quantitative analysis of different excitation processes governing the spectroscopic emissions is essential to study the chemistry of inner coma and to derive neutral gas composition.
MagAO IMAGING OF LONG-PERIOD OBJECTS (MILO). I. A BENCHMARK M DWARF COMPANION EXCITING A MASSIVE PLANET AROUND THE SUN-LIKE STAR HD 7449*
Authors: Rodigas Timothy J. , Arriagada Pamela , Faherty Jackie , Anglada-Escudé Guillem , Kaib Nathan , Butler R. Paul , Shectman Stephen , Weinberger Alycia , Males Jared R. , Morzinski Katie M. , Close Laird M. , Hinz Philip M. , Crane Jeffrey D. , Thompson Ian , Teske Johanna , Díaz Matías , Minniti Dante , Lopez-Morales Mercedes , Adams Fred C. , Boss Alan P. 
Published: February 2016

ABSTRACT
We present high-contrast Magellan adaptive optics images of HD 7449, a Sun-like star with one planet and a long-term radial velocity (RV) trend. We unambiguously detect the source of the long-term trend from 0.6–2.15 μm at a separation of ∼0.″54. We use the object’s colors and spectral energy distribution to show that it is most likely an M4–M5 dwarf (mass ∼0.1–0.2

) at the same distance as the primary and is therefore likely bound. We also present new RVs measured with the Magellan/MIKE and Planet Finder Spectrograph spectrometers and compile these with archival data from CORALIE and HARPS. We use a new Markov chain Monte Carlo procedure to constrain both the mass (

at 99% confidence) and semimajor axis (∼18 AU) of the M dwarf companion (HD 7449B). We also refine the parameters of the known massive planet (HD 7449Ab), finding that its minimum mass is

M

J
, its semimajor axis is

AU, and its eccentricity is

. We use N-body simulations to constrain the eccentricity of HD 7449B to ≲0.5. The M dwarf may be inducing Kozai oscillations on the planet, explaining its high eccentricity. If this is the case and its orbit was initially circular, the mass of the planet would need to be ≲1.5 M

J
. This demonstrates that strong constraints on known planets can be made using direct observations of otherwise undetectable long-period companions.
KIC 9246715: THE DOUBLE RED GIANT ECLIPSING BINARY WITH ODD OSCILLATIONS
Authors: Rawls Meredith L. , Gaulme Patrick , McKeever Jean , Jackiewicz Jason , Orosz Jerome A. , Corsaro Enrico , Beck Paul G. , Mosser Benoît , Latham David W. , Latham Christian A. 
Published: February 2016

ABSTRACT
We combine Kepler photometry with ground-based spectra to present a comprehensive dynamical model of the double red giant eclipsing binary KIC 9246715. While the two stars are very similar in mass (

,

) and radius (

,

), an asteroseismic analysis finds one main set of solar-like oscillations with unusually low-amplitude, wide modes. A second set of oscillations from the other star may exist, but this marginal detection is extremely faint. Because the two stars are nearly twins, KIC 9246715 is a difficult target for a precise test of the asteroseismic scaling relations, which yield M = 2.17 ± 0.14 M
⊙ and R = 8.26 ± 0.18 R
⊙. Both stars are consistent with the inferred asteroseismic properties, but we suspect the main oscillator is Star 2 because it is less active than Star 1. We find evidence for stellar activity and modest tidal forces acting over the 171 day eccentric orbit, which are likely responsible for the essential lack of solar-like oscillations in one star and weak oscillations in the other. Mixed modes indicate the main oscillating star is on the secondary red clump (a core-He-burning star), and stellar evolution modeling supports this with a coeval history for a pair of red clump stars. This system is a useful case study and paves the way for a detailed analysis of more red giants in eclipsing binaries, an important benchmark for asteroseismology.