bluuebunny/crossref_metadata_2025_split huggingface dataset:
“She mimicked the manipulations on my hand”: fostering embodied care among children with recurrent acute respiratory tract infections in Southern China
Authors: Yin Lingjia , Chang Bei , Lundborg Cecilia Stålsby , Wu Darong , Alvesson Helle Mølsted 
Published: October 2024

Abstract
Introduction
When young children experience recurrent respiratory infections, caregivers face the challenge of preventing new episodes whilst maintaining close rapport with their children. Pediatric massage, such as pediatric Tuina, entails soft massage of the skin, administered by trained providers. This non-pharmaceutical measure is used to prevent new respiratory infections in China. The aim of this study is to deepen our understanding of caregivers’ experiences and perceptions of providing pediatric Tuina treatment to their children with recurrent respiratory tract infections.

Methods
A qualitative study, based on semi-structured interviews, was conducted in accordance with the Consolidated Criteria for Reporting Qualitative Research checklist. Sixteen mothers from Southern China, whose children had received pediatric Tuina for recurrent respiratory tract infections, participated online. Analysis was conducted according to the principles of reflexive thematic analysis, using the NVivo qualitative research software.

Results
The overarching theme was “Fostering embodied care with children”. Caregivers assessed pediatric Tuina by hearing others’ experiences of pediatric Tuina, as well as observing the manipulations on their child’s body and their bodily reactions during pediatric Tuina sessions. Caregivers also closely observed children’s bodily changes after pediatric Tuina sessions. Embodied attachment between children and adults was nurtured through the pediatric Tuina. Compared to other treatments or medical consultations, children were more relaxed and more involved in embodied care, which involved direct skin touching and verbal communication from the pediatric Tuina provider. Children also took the initiative to bring pediatric Tuina into their family life, by asking caregivers to perform it on them and mimicking the manipulations on the caregivers’ hand.

Conclusions
Pediatric Tuina served as a means of interaction between children and adults, fostering an embodied care on both a physical and emotional level. Beyond its potentially preventive effect on recurrent respiratory tract infections, pediatric Tuina could be a support for parents of children with recurrent or chronic disease at home.
Protocol for a randomized controlled trial: exercise-priming of CBT for depression (the CBT+ trial)
Authors: Meyer Jacob D. , Kelly Shania J. E. , Gidley John M. , Lansing Jeni E. , Smith Seana L. , Churchill Sydney L. , Thomas Emily B. K. , Goldberg Simon B. , Abercrombie Heather C. , Murray Thomas A. , Wade Nathaniel G. 
Published: October 2024

Abstract
Background
Depression is a leading cause of disability worldwide, and treatments could be more effective. Identifying methods to improve treatment success has the potential to reduce disease burden dramatically. Preparing or “priming” someone to respond more effectively to psychotherapy (e.g., cognitive behavioral therapy [CBT]) by preceding sessions with aerobic exercise, a powerful neurobiological activator, could enhance the success of the subsequently performed therapy. However, the success of this priming approach for increasing engagement of working mechanisms of psychotherapy (e.g., increased working alliance and behavioral activation) has yet to be formally tested.

Methods
The CBT + trial will be a parallel-arm randomized controlled trial that will recruit 40 adult participants with DSM-5 diagnosed depression (verified with clinical interview) via referrals, mass emails, local flyers, and social media posts. Participants will be randomized to an ActiveCBT or CalmCBT condition. The ActiveCBT group will receive an 8-week CBT intervention primed with 30 min of moderate-intensity aerobic exercise (cycling on a stationary bike at a 13 rating of perceived exertion). The CalmCBT group will receive the same 8-week CBT intervention while resting for 30 min before CBT (i.e., cycling vs no cycling is the only difference). The primary outcome measures will be mean working alliance (assessed with the client version of the Working Alliance Inventory—Short Revised) and mean behavioral activation (self-reported Behavioral Activation for Depression Scale) recorded at each of the 8 therapy sessions. Secondary outcomes include evaluation of state anhedonia and serum brain-derived neurotrophic factor before the active/calm conditions, between the condition and therapy, and after the therapy. Additional exploratory analyses will evaluate group differences in algorithm-generated ratings of therapist-participant interactions via the Lyssn platform.

Discussion
The novel approach of priming CBT with moderate-intensity aerobic exercise evaluated in a randomized controlled trial (CBT + trial) has the potential to demonstrate the usefulness of exercise as an augmentation strategy that improves working mechanisms of therapy and overall treatment outcomes for adults with depression.

Trial registration
ClinicalTrials.gov NCT06001346. Registered on August 21, 2023.
Design and rationale for an empirical investigation of the resource use and costs of investigator-initiated randomized trials in Switzerland, the UK, and Germany
Authors: Griessbach Alexandra , Speich Benjamin , Dutilh Gilles , Treweek Shaun , Schwenkglenks Matthias , Briel Matthias ,   on behalf of the MAking Randomized Trials Affordable (MARTA) Group
Published: October 2024

Abstract
Background
Conducting high-quality randomized clinical trials (RCTs) is challenging, time consuming, and resource intense. Academic investigators usually depend on scarce financial resources; however, current literature lacks systematically collected empirical data on the detailed resource use and costs of investigator-initiated RCTs.

Methods
The aim of this study is to generate a database of detailed empirical resource use and cost data from 100 investigator-initiated RCTs in Switzerland, Germany, and the UK. Investigators enter their empirical costs data into an online data collection form, which is followed by a short interview and a detailed cost report. We plan to investigate cost patterns and cost drivers and examine planned versus actual RCT costs as well as explore different strata of costs across the planning, conduct, and finalization phases, in drug and non-drug trials, and across medical fields and countries.

Discussion
This study will add detailed empirical data to the limited research on investigator-initiated RCT costs currently available. A study limitation will be that cost data will be retrospective and self-reported, which might be inaccurate depending on how costs were recorded.

Trial registration
Open Science Framework (OSF) https://doi.org/10.17605/OSF.IO/QY2GU. Registered on June 4, 2021.
Inclusion of people with multiple long-term conditions in pregnancy research: patient, public and stakeholder involvement and engagement in a randomised controlled trial
Authors: Vowles Zoë , Ashworth Danielle C. , Barron Rebecca L. , Conti-Ramsden Frances , Wilson Hannah , Leighton Lisa , Wall Louise , Walter Cherrelle , Myers Jenny , Chappell Lucy C. 
Published: October 2024

Abstract
Background
Both pregnant women and those with multiple long-term conditions are under-served groups in clinical research. Informing and improving research through patient and public involvement, including pregnant women with two or more long-term health conditions, is critical to increasing their inclusion in maternity research. Giant PANDA is a randomised controlled trial, evaluating the effect of a treatment initiation strategy with nifedipine versus labetalol on severe maternal hypertension and a composite outcome of fetal/neonatal death, or neonatal unit admission. We aimed to undertake a mixed methods study-within-a-project within the Giant PANDA trial to understand barriers and facilitators to participation, understand and optimise current representativeness of clinical trial delivery of those with multiple long-term conditions and co-create a checklist to support their inclusion in pregnancy research.

Methods
We undertook online workshops with women with lived experience and hybrid workshops with healthcare professionals who look after women with multiple long-term conditions. A site audit of Giant PANDA sites provided insights into research delivery capacity and health system set-up, and how this influences inclusion. An extension to the Giant PANDA screening log captured data on multiple long-term conditions enabling analysis of the impact of these health conditions on women’s inclusion in the trial. We co-created a checklist of recommendations for those designing and recruiting to similar clinical trials.

Results
Five key recommendations were identified including a need to (1) involve women with multiple long-term conditions as partners in maternity research and (2) minimise barriers that stop them from taking part through (3) designing and delivering research that is flexible in time and place (4) consider research as part of care for everyone, including those with multiple long-term conditions and (5) measure and report inclusion of those with two or more health conditions in maternity research. Multiple long-term conditions were not a barrier to recruitment or randomisation in the Giant PANDA trial.

Conclusion
Women with multiple long-term conditions would like opportunities to find out about and participate in research which accounts for their needs. Our checklist aims to support those designing and delivering maternity research to optimise inclusion of individuals with multiple-long term conditions.
Trial registration: Giant PANDA: EudraCT number: 2020-003410-12, ISRCTN: 12,792,616.
Revitalizing subterranean spaces: a comprehensive study on enhancing air quality in underground shopping malls for sustainable urban living
Authors: Kim Kichul , Kim Jiwoong , Lee Yun Gyu , Wi Seunghwan , Kim Sumin 
Published: October 2024

AbstractCities worldwide are increasingly turning to underground spaces to address the challenges posed by high population density. These subterranean areas are now utilized for various purposes such as offices, shopping malls, subway terminals, and underground sidewalks. However, the semi-closed nature of most underground spaces presents difficulties in ensuring a comfortable environment due to the lack of natural ventilation. This study focuses on a representative underground shopping mall in South Korea, utilizing preliminary surveys and long-term sensor monitoring to identify existing problems. The aging ventilation system was retrofitted to enhance and assess indoor air quality. As a result, concentrations of carbon dioxide, total volatile organic compounds, and radon were reduced by over 33, 74, and 98%, respectively, while particulate matter with a diameter of 2.5 μm or less (PM2.5) concentrations remained the same as before. This not only contributed to maintaining proper indoor air quality, but also led to a reduction in total energy consumption. The goal of this project is to improve air quality in facilities located in underground spaces, such as underground shopping malls, where indoor air quality management is challenging, thereby creating a safe and healthy environment for users and enhancing the overall functionality of the facility.
Reporting three rare pathogenic variants at the CFTR gene in two unrelated Iranian Azeri children with cystic fibrosis
Authors: Hosseini-Asl S. Erfan , Khalafi Jafar , Seyedhashemi Effat , Farajollahi Reza , Ahkavan Homa , Hosseini-Asl S. Saied 
Published: October 2024

Abstract
Background
Cystic fibrosis (CF) is an autosomal recessive inherited life-threatening disease that causes changes in the electrolyte transport system, leading to high absorption of sodium and water. Disease-causing variants of the CFTR gene are responsible for this disease. In the present study, three rare pathogenic variants were identified in two unrelated Iranian Azeri children with CF.

Case presentation
One child affected with CF was found to have two rare variants, c.1545_1546delTA and c.3196C > T, detected through Sanger sequencing of the entire coding region and promoter of the CFTR gene. Another patient was identified as compound heterozygous for the variant c.1545_1546delTA and a rare variant, c.2998delA, which has not been previously reported. The variants were found to be in trans, as both parents were heterozygous for the variants.

Conclusion
The rare variant c.1545_1546delTA has been previously reported as a known variant in certain populations, including Azeris in northwest Iran. Our results, along with previous findings, suggest that this variant may be considered a founder mutation in specific geographical regions. The variant c.2998delA has not been previously reported as pathogenic. Following the guidelines of the American College of Genetics and Genomics and considering the proband's symptoms, we classified this variant as pathogenic based on criteria PVS1, PS4, PM3, PP1, and PM2. The identified variants in the CFTR gene as well as the previously reported variants could serve as a basis for future genetic counseling and prenatal diagnosis in Iran.
A new approach for optimal design of intensive care unit
Authors: Wahed Manal Abdel , Saleh Neven 
Published: October 2024

AbstractPlanning and budgeting for healthcare facilities necessitate precise estimation and a thoughtful analysis of the required area for each department, as well as extensive knowledge of the most important elements that can influence the design and provide an appropriate environment for staff and patients. A gross conversion factor is influential in calculating the entire area of a department. However, there is no precise standard indicating how this factor should be calculated. To address this problem, quality function deployment (QFD) has been implemented. The intensive care unit (ICU) is one of the highly equipped departments that should be properly planned; therefore, it was selected for application. The five steps of the QFD are used to identify and rank the most important and efficient design features. Only the top factors are considered in calculating the required area for the ICU department. This approach presents a unique method for estimating the gross square area based on calculating the gross conversion factor. To demonstrate the proposed approach’s efficacy, it was applied to two Egyptian public hospitals. The results reveal that 15–16% of the total space of both hospitals can be reduced from the total department space. Moreover, an outstanding reduction in ICU design and preparation expenses has been achieved. The design reduces the required budget for a project while maintaining the same construction material quality and accommodating extra beds. Additionally, the QFD proves its ability to redesign the ICU department while reducing costs.
Socioeconomic Status and Obesity
Authors: Autret Kristen , Bekelman Traci A 
Published: October 2024

Abstract
Obesity is a pervasive public health problem that causes debilitating complications across the life course. One opportunity for preventing the onset of obesity is to focus on its social determinants. Socioeconomic status (SES), which includes factors such as income, educational attainment, occupational prestige, and access to resources, is a key determinant of obesity. In this scoping mini-review, we summarized review articles and meta-analyses of the SES-obesity association. From the 1980s to the present, cross-sectional studies have demonstrated a persistent socioeconomic gradient in obesity in which the association is negative in developed countries and positive in developing countries. Longitudinal studies have revealed the bidirectionality of the SES-obesity association; some studies demonstrate that socioeconomic adversity precedes the onset of obesity, while others provide evidence of reverse causality. While earlier studies relied on anthropometric assessments of weight and height to define obesity, the use of modern technologies like dual-energy x-ray absorptiometry and bioelectrical impedance have demonstrated that the socioeconomic gradient in obesity is robust across multiple indicators of body composition, including direct measures of lean and fat mass. More recently, examination of mediators and moderators of the SES-obesity association have highlighted causal pathways and potential intervention targets, with a focus on health behaviors, environmental conditions, psychological factors, and biological processes. We describe current gaps in knowledge and propose opportunities for future innovation to reduce the burden of obesity and related socioeconomic disparities.
Nuclear instance segmentation and tracking for preimplantation mouse embryos
Authors: Nunley Hayden , Shao Binglun , Denberg David , Grover Prateek , Singh Jaspreet , Avdeeva Maria , Joyce Bradley , Kim-Yip Rebecca , Kohrman Abraham , Biswas Abhishek , Watters Aaron , Gal Zsombor , Kickuth Alison , Chalifoux Madeleine , Shvartsman Stanislav Y. , Brown Lisa M. , Posfai Eszter 
Published: October 2024

ABSTRACT
For investigations into fate specification and morphogenesis in time-lapse images of preimplantation embryos, automated 3D instance segmentation and tracking of nuclei are invaluable. Low signal-to-noise ratio, high voxel anisotropy, high nuclear density, and variable nuclear shapes can limit the performance of segmentation methods, while tracking is complicated by cell divisions, low frame rates, and sample movements. Supervised machine learning approaches can radically improve segmentation accuracy and enable easier tracking, but they often require large amounts of annotated 3D data. Here, we first report a previously unreported mouse line expressing near-infrared nuclear reporter H2B-miRFP720. We then generate a dataset (termed BlastoSPIM) of 3D images of H2B-miRFP720-expressing embryos with ground truth for nuclear instances. Using BlastoSPIM, we benchmark seven convolutional neural networks and identify Stardist-3D as the most accurate instance segmentation method. With our BlastoSPIM-trained Stardist-3D models, we construct a complete pipeline for nuclear instance segmentation and lineage tracking from the eight-cell stage to the end of preimplantation development (&gt;100 nuclei). Finally, we demonstrate the usefulness of BlastoSPIM as pre-train data for related problems, both for a different imaging modality and for different model systems.
Symmetry breaking and fate divergence during lateral inhibition in Drosophila
Authors: Phan Minh-Son , Kim Jang-mi , Picciotto Cara , Couturier Lydie , Veits Nisha , Mazouni Khallil , Schweisguth François 
Published: October 2024

ABSTRACT
Lateral inhibition mediates alternative cell fate decision and produces regular cell fate patterns with fate symmetry breaking (SB) relying on the amplification of small stochastic differences in Notch activity via an intercellular negative-feedback loop. Here, we used quantitative live imaging of endogenous Scute (Sc), a proneural factor, and of a Notch activity reporter to study the emergence of sensory organ precursor cells in the pupal abdomen of Drosophila. SB was observed at low Sc levels and was not preceded by a phase of intermediate Sc expression and Notch activity. Thus, mutual inhibition may only be transient in this context. In support of the intercellular feedback loop model, cell-to-cell variations in Sc levels promoted fate divergence. The size of the apical area of competing cells did not detectably bias this fate choice. Surprisingly, cells that were in direct contact at the time of SB could adopt the sensory organ precursor cell fate, albeit at low frequency (10%). These lateral inhibition defects were corrected by cellular rearrangements, not cell fate change, highlighting the role of cell-cell intercalation in pattern refinement.
Is fluoride the best we've got? The most common toothpaste active ingredients and their influence on caries and oral health: A brief review of the literature
Authors: Kowalska Klaudia , Weronika Kiełt  , Julia Kozłowska  , Gabriela Broniec  , Barbara Wajdowicz  , Aleksandra Kudła  , Rozalia Czapiewska  , Aleksandra Dziewulska  , Aleksandra Wróbel  , Laura Pacek  
Published: October 2024

Aim of the study
Toothpaste is a paste or gel to be used with a toothbrush to maintain and improve oral health and aesthetics. Nowadays there is a great variety of ingredients that might have different effects on caries development or oral health in general. Society continues to seek ways to replace fluoride or include more natural ingredients in everyday hygiene products. The aim of our study is to present current knowledge of various ingredients in toothpastes regarding their influence on teeth and intraoral soft tissues and the possibility of replacing fluoride with other substances.
Material and methods
Our review is based on the analysis of materials collected in„Pubmed”, „Google Scholar” and other scientific articles using keywords: „toothpaste”, „fluoride”, „ingredients”, “hydroxyapatite”, „chlorhexidine”, “triclosan”, “propolis”, “aloe vera”, “charcoal”, “oleanolic acid”, “SLS”, “xylitol”
Conclusions
Despite numerous studies, there is space for further research in finding substances that might improve toothpastes with or without extracting fluoride from them. Fluoride has the most proven effectiveness in caries prevention, with fluorosis as its most damaging side effect, while hydroxyapatite shows promising results. Although, there are many substances that might be useful in oral health care products.
Development and evaluation of a one-stop surgical outpatient clinic to tackle waiting lists
Authors: Lassman Eliza King , Butnari Valentin , Mansuri Ahmer , Murphy Patricia , Amalesh Thangadorai , Shatkar Veeranna 
Published: October 2024

Background/Aims The COVID-19 pandemic caused substantial disruption to elective surgery, with NHS trusts still trying to work through their backlogs and reduce waiting lists. This study aimed to design, implement and evaluate a novel one-stop general surgical outpatient clinic to tackle long waiting lists post COVID-19. Methods General surgical outpatient clinics were held on 6 days between April and October 2021. The impact of these clinics was retrospectively measured using data collected from the trust's electronic database on the length of waiting lists, number of weeks before appointment and financial expenditure associated with the project. Results There were 1440 fewer patients on the outpatient waiting list after the clinics were implemented compared to before, with a 100% reduction in the number of patients waiting longer than 52 weeks for an appointment. Across the six clinic days, 93.7% of available slots were booked and patients attended 90.5% of booked slots. A net financial benefit of £128 700 was calculated. Conclusions Lessons from this project could be applied in other specialties and NHS trusts to tackle waiting lists and outpatient clinic backlog post COVID-19.