bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower Extremity Asymmetry Values Derived From Multiple Strength Testing Modes Are Associated With Perceived Functional Capabilities Among University Athletes
Authors: McClean Zachary J. , Mossel Nathan Boon-van , McKenzie Mark , Aagaard Per , Herzog Walter , Pasanen Kati , Lun Victor , Jordan Matthew J. 
Published: October 2024

Background: Muscle strength asymmetry and athlete introspective measures are associated with musculoskeletal (MSK) sport injury and reinjury. However, the interrelationship between mechanical and subjective measures of concentric and eccentric limb function needs further exploration. This includes investigating if an athlete’s perception of their overall MSK function influences limb asymmetry across different testing modalities.Objectives: To (i) explore the interrelationship between mechanical and subjective measures of lower limb function in university athletes and (ii) compare the consistency in interlimb strength asymmetries across different strength tests in groups of athletes with good, fair, and poor perceived limb function.Methods: University athletes (n = 175; n = 87 females) from six sports completed four tests of muscle strength, power, and plyometric function along with an assessment of perceived limb function using the Sport Fitness Index (SFI). Participants were categorized into high (GOODSFI), fair (FAIRSFI), and poor (POORSFI) perceived overall MSK function (perceived function) groups. Strength asymmetry indexes evaluated interlimb differences in concentric and eccentric maximal strength, countermovement jump (CMJ) impulse, unilateral CMJ height, and reactive strength index in unilateral repeat hop testing. Cumulative link mixed‐effects models assessed the relationship between strength asymmetries and perceived limb function.Results: The POORSFI group showed increased asymmetry in concentric strength testing (p = 0.022), more consistent interlimb asymmetries (p < 0.001), and reduced overall muscle strength compared to the GOODSFI group.Conclusion: Higher interlimb asymmetry in maximal concentric strength measures along with reduced muscle strength was found in the POORSFI group compared to the GOODSFI group. The POORSFI group also showed greater consistency in muscle strength asymmetry derived across different tasks.
Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Authors: Fandrei David , Seiffert Sabine , Rade Michael , Rieprecht Susanne , Gagelmann Nico , Born Patrick , Wiemers Thomas , Weidner Heike , Kreuz Markus , Schassberger Tamara , Koßmann Jannik , Mangold Marlene , Fürst Daniel , Fischer Luise , Baber Ronny , Heyn Simone , Wang Song Yau , Bach Enrica , Hoffmann Sandra , Metzeler Klaus H. , Herling Marco , Jentzsch Madlen , Franke Georg-Nikolaus , Köhl Ulrike , Friedrich Maik , Boldt Andreas , Reiche Kristin , Platzbecker Uwe , Vucinic Vladan , Merz Maximilian 
Published: October 2024

Abstract
Establishing a strategy for sequencing of T cell–redirecting therapies for relapsed/refractory multiple myeloma (RRMM) is a pressing clinical need. We longitudinally tracked the clinical and immunologic impact of bispecific T cell–engaging antibodies (BsAb) as bridging therapy (BT) to subsequent B-cell maturation antigen–directed chimeric antigen receptor T (CAR-T) cell therapies in 52 patients with RRMM. BsAbs were a potent and safe option for BT, achieving the highest overall response rate (100%) to BT compared with chemotherapy, anti-CD38, or anti-SLAMF7 antibody–based regimens (46%). We observed early CD4+CAR+ and delayed CD8+CAR+ T-cell expansion in patients receiving BsAbs as BT. In vitro cytotoxicity of CAR-T cells was comparable among BT options. Single-cell analyses revealed increased clonality in the CD4+ and CD8+ T-cell compartments in patients with previous exposure to BsAbs at leukapheresis and on day 30 after CAR-T cell infusion. This study demonstrates the feasibility and efficacy of BT with BsAbs for CAR-T cell therapy in RRMM.
Significance: CAR-T cell therapy and BsAbs have revolutionized treatment of triple-class refractory multiple myeloma; however, optimal sequencing is unknown. We demonstrate that BT with BsAb before B-cell maturation antigen–directed CAR-T cell therapy is safe and effective, which might have implications for other hematologic malignancies as well.
See related commentary by Bal and Costa, p. 10
Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Authors: Ridnour Lisa A. , Heinz William F. , Cheng Robert Y.S. , Wink Adelaide L. , Kedei Noemi , Pore Milind , Imtiaz Fatima , Femino Elise L. , Gonzalez Ana L. , Coutinho Leandro L. , Moffat Rebecca L. , Butcher Donna , Edmondson Elijah F. , Li Xiaoxian , Rangel Maria Cristina , Kinders Robert J. , Rittscher Jens , Lipkowitz Stanley , Wong Stephen T.C. , Anderson Stephen K. , McVicar Daniel W. , Glynn Sharon A. , Billiar Timothy R. , Chang Jenny C. , Hewitt Stephen M. , Ambs Stefan , Lockett Stephen J. , Wink David A. 
Published: October 2024

<p>Defined CD8 NOS2 and COX2 spatial landscape. Five basic regions showing (<b>A</b>) margin or stroma-restricted lymphoid aggregates (orange circles) in which a gap of 50 μm (double orange arrow) between CD3<sup>+</sup> T-cell aggregates and the CKSOX10<sup>+</sup> tumor edge (green circle) was observed. Blue and dashed magenta circles identify immune desert regions lacking CD8<sup>+</sup> T cells. <b>B,</b> Tumor fragmentation or satellite region. <b>C,</b> Tumor edge with proximal stroma regions. <b>D,</b> Significant differences in % cell composition is shown for CD8<sup>+</sup> T cells as well as (<b>E</b>) NOS2<sup>+</sup> and (<b>F</b>) COX2<sup>+</sup> tumor cells. <b>G,</b> Graphic summary of tumor NOS2/COX2 landscape and CD8<sup>+</sup> T-cell regional distributions with respect to the tumor–stroma interface. <b>H,</b> Spatial architecture of predictive phenotypes in tumors from deceased vs. alive patients. <i>*, P</i> ≤ 0.05; **, <i>P</i> ≤ 0.01; ***, <i>P</i> ≤ 0.001; ****, <i>P</i> ≤ 0.0001.</p>
Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Authors: Ridnour Lisa A. , Heinz William F. , Cheng Robert Y.S. , Wink Adelaide L. , Kedei Noemi , Pore Milind , Imtiaz Fatima , Femino Elise L. , Gonzalez Ana L. , Coutinho Leandro L. , Moffat Rebecca L. , Butcher Donna , Edmondson Elijah F. , Li Xiaoxian , Rangel Maria Cristina , Kinders Robert J. , Rittscher Jens , Lipkowitz Stanley , Wong Stephen T.C. , Anderson Stephen K. , McVicar Daniel W. , Glynn Sharon A. , Billiar Timothy R. , Chang Jenny C. , Hewitt Stephen M. , Ambs Stefan , Lockett Stephen J. , Wink David A. 
Published: October 2024

<p>Spatial analysis of tumor NOS2/COX2 expression with respect to survival. Spatial landscape of NOS2 (red) and COX2 (green) with DAPI (white), the tumor marker CKSOX10 (blue) for (<b>A</b>) deceased and (<b>B</b>) alive patients at 5-year survival. <b>C,</b> Quantification of NOS2/COX2 tumor expression at the single cell level, with each dot representing a tumor sample (also shown in Supplementary Fig. S2). <b>D,</b> Heat density maps of tumor NOS2/COX2 expression in deceased and alive patient tumors. <b>E,</b> Significant Pearson’s correlation between tumor NOS2 and COX2 expression <i>R</i><sup>2</sup> = 0.8481 and <i>P</i> < 0.0001 in tumors from deceased patients but not alive patient samples (<b>F</b>). Mann–Whitney *, <i>P</i> < 0.05; **, <i>P ≤ </i>0.01.</p>
‘Foreign’ Trademarks in Jordan and the Influence of Imperial Powers
Authors: Naser Mohammad Amin , Haddadin Suhail H. 
Published: October 2024

Abstract
The Jordanian Trademarks Law, as it stands today, suffered from the influence of imperial powers. Namely, the influence of the USA and UK has resulted in the introduction of a classification of trademarks, which is: “Foreign Trademarks”. This paper proves the said influence through the standard of well-known trademarks under the Jordanian Trademarks Law, in addition to the preferential treatment of the foreign trademarks in terms of invalidity and annulment. It is argued that the privileges given to foreign trademarks were to the detriment of national trademarks. This paper is a call for Jordan to put national interests first in this area of law, and advances an argument for a legislative reform, De lege ferenda, and the way Jordanian courts and the trademarks’ registrar should deal with the law as it stands today, De lege lata, in order to mitigate the loss that ‘national’ marks currently suffer from.
Viability fertility and SEM studies on cryopreserved pollen of cashew (Anacardium occidentale L.)
Authors: Veena G.L. , Mog Babli , Adiga J.D. , Rajasekharan P.E. , Eradasappa E. , Yadav Anil Kumar , Shamsudheen M. , Manjesh G.N. , Thondaiman V. , Harsha R. , Aswathy C. 
Published: October 2024

Abstract
Cryopreservation can be utilized as an efficient and reliable tool for long-term conservation of cashew genetic diversity. This study aims at pollen germination in vitro, SEM studies, pollen cryopreservation and fruit set with cryostored pollen of cashew. Brewbaker’s and Kwack (1963) medium enriched with 30% sucrose and15% PEG elicited significant pollen germination in vitro. Madakkathara-2 recorded high viability profiles both with respect to fresh (90.32%) and cryopreserved (85.53%) pollen when compared to other genotypes and species. Anacardium othonianum recorded lower viability in fresh (40.97%) as well as cryopreserved (25.43%). The pollen grains were cryopreserved for six months and post viability assessment was carried out at regular intervals. Field pollination was carried and in vivo fertility was assessed using four month cryostored pollen. A fruit set range of13.17 to 30.67% and a seed germinability range from 37.75 to 63.64% was recorded. Both in vitro and in vivo results show the reliability of pollen cryopreservation, which can be effectively used in breeding and conservation of the cashew gene pool.
Adapting a human sexuality curriculum for students with disabilities
Authors: Lepore-Stevens Maria 
Published: October 2024

Background: The US Individuals with Disabilities Education Act requires that children with disabilities receive a free appropriate public education. However, it does not specifically include the subject of health education. Currently, 30 US states require public schools to teach sexuality education as a part of the health education curriculum, but 36 do not include youth with disabilities in their sexuality education requirements. Objective: The current situation is particularly concerning due to the higher rates of unplanned pregnancy, sexual abuse, and sexually transmitted infections experienced by teenagers with disabilities. Students from across several disability groups report societal barriers, physical barriers, and poor educational outcomes with respect to sexuality education. Results: This review article sought to investigate the current state of sexuality education for students with disabilities, as well as best practices to support the learning of sexuality education content. Conclusion: Focusing sexuality education classes on practical ways so as to develop relationships, promote self-advocacy and self-determination, and incorporate privacy messages, can support students with disabilities to make healthy choices.
Acculturation stress and mental health outcomes in a sample of migrant inpatients: Findings from a naturalistic study
Authors: Della Rocca Bianca , Di Vincenzo Matteo , Giallanella Daniela , Gaggiano Costanza , Martinelli Flavia , Ricci Fabiana , Sampogna Gaia , Luciano Mario , Ventriglio Antonio , Bellomo Antonello , Fiorillo Andrea 
Published: October 2024

Introduction: Migrants face numerous risk factors for mental disorders, including stressors and traumatic events during the pre-, peri-, and post-migratory phases. Acculturation stress, a significant post-migratory stressor, can adversely affect mental health during the cultural adaptation process. This study aims to assess the clinical implications of acculturation stress in migrants admitted to a psychiatric intensive care unit, with a focus on identifying predictors of acculturative stress and their impact on clinical outcomes. Methods: We conducted a retrospective study of 268 immigrant patients hospitalized between 2004 and 2019 at the psychiatric inpatient unit of the University of Foggia. We collected socio-demographic and clinical data using ad hoc schedules and validated assessment instruments, including the Brief Psychiatric Rating Scale (BPRS), the Global Assessment of Functioning (GAF), and the Clinical Global Impression (CGI). Diagnoses were based on DSM-IV-TR/DSM-5 criteria. We analyzed associations between demographic and clinical characteristics of patients reporting acculturative stress and those not reporting it, using appropriate statistical methods. Results: The majority of patients were diagnosed with affective (45.1%) or psychotic disorders (31.7%), with 57.1% experiencing their first psychiatric episode. Acculturation stress was reported by 51.9% of patients ( N = 139), predominantly among males (71.9%), single individuals (80.9%), and those of Islamic faith (56.8%). Patients experiencing acculturation stress were more likely to be unemployed (57.6%) and without a residence permit (63.3%). This stress was particularly prevalent among patients with psychotic disorders (25.9%) and first-episode psychiatric cases (64.7%). At discharge, patients with acculturation stress showed less improvement on CGI, GAF, and BPRS scores compared to those without such stress. Conclusions: Acculturation stress is influenced by several socio-demographic factors and is crucial for the full symptomatic remission of migrant patients. Culturally-oriented mental health services, including language and cultural integration programs, are essential in reducing acculturative stress and improving the overall well-being of immigrants.
The Critical Shoulder Angle as a Highly Specific Predictor of a Full-Thickness Rotator Cuff Tear: A Case-Control Study
Authors: Gerlach Erik , Nicolay Richard W. , Nayak Rusheel , Williams Carly L. , Johnson Daniel J. , Plantz Mark , Marra Guido 
Published: October 2024

Background: The critical shoulder angle (CSA) has become an important topic of study in patients with rotator cuff tears (RCTs). However, there are conflicting data on whether the CSA can differentiate between patients with normal shoulder pathology and full-thickness RCTs on shoulder radiographs. Purpose/Hypothesis: The purpose of this study was to define the relationship between full-thickness RCTs and the CSA. It was hypothesized that patients with full-thickness RCTs would have an increased CSA compared with matched controls. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This retrospective case-control study identified patients with magnetic resonance imaging scans showing full-thickness RCTs between 2009 and 2019. A 1 to 1 propensity score match was performed to identify a control group with normal rotator cuffs while controlling for baseline participant characteristics—including age, sex, body mass index, and tobacco use. A total cohort of 532 was identified, with 266 cases and 266 controls. Two independent observers measured CSAs on true anteroposterior shoulder radiographs. Results: There was no difference in baseline participant characteristics between the RCT and the non-RCT groups ( P > .05). The mean CSA for the entire cohort was 33.6°± 4.2°. The CSA did not significantly vary by sex ( P = .088) or tobacco usage ( P = .16). The mean CSA for the RCT case group, 36.2°± 3.3°, was significantly different from the mean CSA for the control group, 30.9°± 3.3° ( P < .0001). The receiver operating characteristic curve analysis produced an area under the curve of 0.88 ( P < .0001). At CSAs ≥35°, there was a 67.7% sensitivity and 89.4% specificity for having a full-thickness RCT. Last, each degree of increase in the CSA increased the risk of having an associated RCT by 1.7 times (OR, 1.7 [95% CI, 1.551-1.852]; P < .0001). Conclusion: Patients with RCTs had significantly higher CSAs compared with matched controls. Increased CSA was an independent risk factor for RCTs, with an odds ratio of 1.7 per degree. The CSA is an accurate test (area under the curve, 0.88) with good sensitivity (67.7%) and specificity (89.4%) at values ≥35°. The CSA is a simple, reproducible measurement that can assist in clinical decision-making regarding full-thickness RCTs.
Human poisoning with glyphosate-surfactant herbicides: Retrospective analysis of mortality outcomes of patients treated in a poison center
Authors: Liu Kuan-Hung , Chang Shu-Sen , Tu Chao-Ying , Chen Hsien-Yi , Lee Wen-Chin , Tsai Kai-Fan , Kuo Po-Yen , Yen Ju-Ching , Wang I-Kuan , Yen Tzung-Hai 
Published: October 2024

Introduction The toxicity and carcinogenicity of glyphosate have long been debated. Nevertheless, the mortality rate in patients with acute glyphosate-surfactant poisoning varies across different groups. Methods Between 2002 and 2020, 109 patients with glyphosate-surfactant poisoning received treatment at Chang Gung Memorial Hospital. Patients were stratified into two subgroups according to their prognosis: good ( n = 74) or poor ( n = 35). Baseline demographics, psychiatric comorbidities, medical complications, and laboratory data were collected, and mortality data were analyzed. Results The patients were 54.1 ± 17.5 years of age and were mostly male (68.8%). Most patients (91.7%) ingested pesticides intentionally, and patients arrived at the hospital within 7.1 ± 12.7 h. Psychiatric comorbidities were prevalent, and the top three comorbidities were mental (71.6%), depressive (48.6%), and adjustment (14.7%) disorder. Patients with poor prognoses were older than those with good prognoses ( p = .007). Moreover, patients with poor prognoses had lower Glasgow Coma Scale scores ( p < .001) and diastolic blood pressure ( p = .008), but higher incidences of upper gastrointestinal bleeding ( p < .001), aspiration pneumonia ( p < .001), hypotension ( p < .001), hyperglycemia ( p = .002), acute kidney injury ( p < .001), and metabolic acidosis ( p < .001) than patients with good prognoses. The mortality rate was 5.5%. A multivariate-logistic-regression model revealed that the Glasgow Coma Scale score was a significant risk factor for poor prognosis (odds ratio 0.653, confidence interval 0.427–0.998; p = .049). However, no risk factors for mortality were identified. Conclusions A total of 32.1% of patients with glyphosate-surfactant poisoning had poor prognoses, and 5.5% of patients died despite treatment. The mortality outcome is comparable to that of published reports from other international poison centers.
Abemaciclib combined with endocrine therapy as adjuvant treatment for hormone-receptor-positive, HER2−, high-risk early breast cancer: 5-year Chinese population analysis of the phase III randomized monarchE study
Authors: Zhang Qingyuan , Shen Kunwei , Song Chuan-gui , Ouyang Quchang , Liu Zhenzhen , Liu Qiang , Feng Jifeng , Chiu Joanne W. Y. , Tang Jinhai , Jiang Zefei , Tseng Ling-Ming , Wang Xiaojia , Yang Liu , Qian Chenxi , Shao Zhimin 
Published: October 2024

Background: Abemaciclib was the first cyclin-dependent kinase 4/6 (CDK4/6) inhibitor approved globally in the adjuvant setting for high-risk hormone-receptor positive (HR+)/human epidermal growth factor 2 negative (HER2−) early breast cancer (EBC), based on the phase III monarchE trial. Objective: To report an exploratory Chinese population analysis based on the preplanned overall survival (OS) interim analysis with 5-year efficacy results of monarchE. Design and methods: Patients with HR+/HER2−, high-risk (⩾4 positive lymph nodes, or 1–3 nodes and either tumor size ⩾5 cm, histologic grade 3, or Ki-67 ⩾20%) EBC were randomized (1:1) to abemaciclib (150 mg twice daily for 2 years) plus endocrine therapy (ET), or ET alone. This analysis included Chinese patients enrolled in mainland China, Hong Kong, and Taiwan. The primary endpoint was invasive disease-free survival (IDFS); key secondary endpoints included distant relapse-free survival (DRFS), safety, and patient-reported outcomes (PROs). Results: Overall, 501 Chinese patients were included (abemaciclib + ET, n = 259; ET, n = 242). With a median follow-up of 53 months, the addition of abemaciclib to ET resulted in improvements in IDFS (estimated 5-year IDFS rate: 85.9% vs 79.1%; hazard ratio (HR), 0.65 (95% confidence interval (CI) 0.41–1.03)) and DRFS (estimated 5-year DRFS rate: 88.4% vs 82.3%; HR, 0.65 (95% CI, 0.39–1.07)). The most common grade ⩾3 treatment-emergent adverse events in the abemaciclib + ET versus ET groups were neutropenia (24.7% vs 0.8%) and leukopenia (22.4% vs 0.4%). Generally, no clinically meaningful difference in PROs (endocrine symptoms and fatigue) was observed between groups, except for diarrhea. Conclusion: At this prespecified OS interim analysis, which provides 5-year data, the addition of abemaciclib to ET in Chinese patients with high-risk HR+, HER2− EBC was associated with sustained and clinically meaningful improvements in IDFS and DRFS, with acceptable safety and tolerability profiles and minimal impact on PROs. These results represent the first full report of a CDK4/6 inhibitor in Chinese patients with EBC and support the positive benefit–risk profile of adjuvant abemaciclib + ET in Chinese patients. Trial registration: ClinicalTrials.gov identifier: NCT03155997 (first posted: May 16, 2017).
Immersive Technologies in Healthcare: An In-Depth Exploration of Virtual Reality and Augmented Reality in Enhancing Patient Care, Medical Education, and Training Paradigms
Authors: Iqbal Arham I. , Aamir Ali , Hammad Abdullah , Hafsa Hafiza , Basit Abdul , Oduoye Malik Olatunde , Anis Muhammad Wajeeh , Ahmed Shaheer , Younus Mohammad Ijlal , Jabeen Sarwat 
Published: October 2024

Background: Virtual reality (VR) and augmented reality (AR) are rapidly gaining traction in healthcare, offering transformative opportunities for patient care, medical education, and therapeutic interventions. Despite their potential, challenges remain regarding the implementation and integration of these technologies into existing healthcare practices. Objective: This review aims to explore the current applications of VR and AR in healthcare, particularly focusing on their roles in enhancing patient care and medical training, as well as identifying research gaps that hinder their widespread adoption. Methods: A comprehensive literature search was conducted across 2 primary databases, PubMed, and Google Scholar. The search was restricted to peer-reviewed articles, systematic reviews, meta-analyses, and randomized controlled trials (RCTs) published from 2000 to 2024. Reference lists of included articles were also examined for additional relevant studies. Inclusion criteria focused on empirical studies addressing the use of VR and/or AR in patient care or medical training, while editorial pieces, non-peer-reviewed sources, and unrelated studies were excluded. A total of 17 900 search results were identified on Google Scholar and 300 on PubMed, leading to the inclusion of 89 articles in this review. Results: The findings indicate that VR and AR technologies significantly enhance patient experiences and medical training, providing immersive and interactive environments for learning and practice. However, notable challenges include integration issues with existing electronic health record systems, the need for appropriate implementation models, and a lack of substantial evidence supporting the clinical efficacy of AR-assisted procedures. Conclusion: While VR and AR hold considerable promise in revolutionizing healthcare practices, further research is essential to address existing gaps, particularly regarding implementation strategies, user acceptance, and empirical evaluation of patient outcomes and training effectiveness. Understanding the needs of healthcare professionals and patients will be critical to maximizing the impact of these technologies in clinical settings.