bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Low Altitude-Hilly Terrain on Pulmonary Health in Young Adults: A Gender-Based Spirometric Analysis
Authors: Goyal Madhav A. , Agarwal Kanishka , Garg Kashika , Jheetay Himani M. , Jheetay Sanket , Bhardwaj Aman 
Published: October 2024

ABSTRACT

Introduction:
This study explores the pulmonary function of young adults living in hilly terrains at low altitudes (around 1,800 ft), assessing the impact of elevation on lung health and potential gender-based differences using digital spirometry.

Materials and Methods:
Pulmonary functions, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, and peak expiratory flow rate, were measured in individuals aged 18–24 years. Differences between males and females were examined using independent t-tests and Pearson correlation tests to analyze the relationships between various pulmonary metrics.

Results:
Males demonstrated higher mean values in FVC and FEV1 compared to females, though the FEV1/FVC ratio remained consistent across genders. Correlation analysis within the total sample and across genders revealed significant relationships among the tests.

Conclusion:
The study highlights low altitude’s physiological effects on lung function, with gender differences in pulmonary findings. These findings necessitate gender-specific approaches in health interventions and emphasize the importance of altitude consideration in respiratory health research.
Evaluation of the Wound Healing Potential of Aloe Vera Leaf Extract Containing Carbopol 934 as a Gelling Agent and Comparing with Sodium CMC and HPMC on Surgically Induced in Wound Wister Rats: A Preclinical Study
Authors: Raj Barani , Ingole Nishikant , Ambad Ranjit 
Published: October 2024

ABSTRACT

Introduction:
The restricted injury can occur in any tissue or organ and is caused by an external source. The toughness and adaptability of the delivery system are enhanced by the synthetic hydrophilic, biocompatible, and biodegradable stable polymer known as carbopol 934. Aloe vera is a plant belonging to the Liliaceae family that releases anthraquinones, a bitter liquid that has medicinal qualities.

Aim:
The current study is to determine if aloe vera gel containing Carbopol 934 can cure wounds in animal models used in experiments.

Need of the Study:
This review will offer a thorough examination of recent studies on the medicinal use of Aloe vera gel. Further study is required to establish the mechanism of action because certain areas, such as wound healing, have not received much attention in the scientific community. However, these biological materials must first be appropriately isolated and identified.

Materials and Methods:
Various centralizations of Carbopol 934, sodium CMC, and HPMC will be attempted, and lastly, gel that showed great spreadability and consistency will be chosen for wound mending properties of homegrown Aloe vera gel.
Impact of Dental Treatment Simulation App on Anxiety of Pediatric Dental Patients: An Observational Study
Authors: Rahaman S. K. Mahboob , Maiti Niladri , Harish Sonali , Achanur Mahantesh , Pramanik Michael S. , Ahmed Adnan 
Published: October 2024

ABSTRACT

Aim:
The study aimed to investigate the effect of a dental treatment simulation app on the anxiety levels of pediatric dental patients.

Materials and Methods:
Forty children, aged 4–8 years and with no prior dental experience, were randomly assigned to either the control group (group I) or the dental app group (group II). The children’s anxiety levels were measured before and after undergoing restorative dental treatment, using the Chota Bheem Chutki pictorial scale.

Results:
The initial anxiety levels were similar across both groups. Post treatment, the dental app group exhibited a significant reduction in anxiety compared to the control group. This suggests that the simulation app has a beneficial effect in lowering dental anxiety in children.

Conclusion:
The dental treatment simulation app can effectively reduce pre and postoperative anxiety in pediatric patients, potentially enhancing their overall dental experience.
The Evaluation of Anti-Osteoclastic Activity of the Novel Calcium Hydroxide Biodegradable Nanoparticles as an Intracanal Medicament
Authors: Gautam Nandita , Bohra Sonam S. K. , Upadhyay Rutvi , Rakesh N. , Patri Gaurav , Roshni R. S. , Shetty Suneeth 
Published: October 2024

ABSTRACT

Objective:
The present investigation looked into PLGA micron-sized particles or NPs, loaded with calcium hydroxide for canal disinfecting processes which have antimicrobial properties, given the significant rejection probabilities related to these kinds of treatments.

Methodology:
The MIC and inhibitory growing zones (n = 5) were found using the broth dilution and agar diffusion tests, accordingly. Employing confocal microscopy and live/dead labelling, cell viability was evaluated (n = 5). ANOVA was used to evaluate, and post hoc analysis came next.

Results:
Ca(OH)2 NPs showed a minimum inhibitory concentration of 5 μg/mL for Fn and 10 μg/mL for Pg and Ef (P < 0.001), following a 24-hour incubation period.

Conclusion:
To sum up, Ca(OH)2-contained PLGA NPs show encouraging ability to kill microbes during canal cleaning treatments.z
A Comprehensive Overview of Internet of NanoThings and its Applications
Authors: Padmavathy V. , Sakthiivanitha M. , Balajikannan  , Poornima V. , Maruthi R. 
Published: October 2024

INTRODUCTION: Internet of NanoThings (IoNT) is regarded as the next generation of the Internet of Things due to its bright future and wide range of applications . According to the global "Internet of Nanothings (IoNT) Market" research, there has been good growth in recent years, and this trend is expected to continue until 2030. IoNT is basically the Internet of Things on a nanoscale. IoNT essentially describes how nanoscale devices are connected to one another within current networks. A high-speed network can be used to connect different nanodevices through the IoNT. This study provides a comprehensive overview of the architecture, benefits and applications of IoNT.
OBJECTIVES: The objective is to provide insights into IoNT framework and it applications in fields like healthcare, food industry, agriculture , environment monitoring etc,
METHODS: This study explored the IoNT architecture and its applications. The exploration involves reviewing the articles, journals and other web resources.
RESULTS: Highlights the aspects of IoNT and emphasizing the importance of its applications in various fields. The need to combine this research and emphasize the IoNT related applications stems from the dearth of research in the field.
CONCLUSION: The world is becoming increasingly developed as a result of ongoing technological advancements. Future developments, which are expected to peak in the next one to two decades, will be led by IoT and nanotechnology. IoNT offers potential and means to enhance numerous facets of individuals' lives. Its primary characteristics are monitoring and diagnostic services, which support and improve decision-making and outcomes across a range of application domains.
Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice
Authors: Li Chun-Mei , Sun Tian , Yang Mou-Jie , Yang Zhi , Li Qing , Shi Jia-Lin , Zhang Chong , Jin Jun-Fei 
Published: October 2024

BACKGROUND
Complement activation is recognized as an important factor in the progression of liver damage caused by acetaminophen (APAP). However, the role of the complement inhibitor C2-FH in APAP-induced liver injury remains unclear.
AIM
To explore C2-FH in protecting against APAP-induced liver injury by inhibiting complement activation.
METHODS
A model of APAP-induced liver injury was used to study the protective effect of C2-FH on liver injury. C2-FH was administered through intraperitoneal injection 30 minutes after APAP treatment. We detected the effects of C2-FH on liver function, inflammatory response and complement activation. Additionally, RNA-sequencing (RNA-Seq) analysis was conducted to understand the mechanism through which C2-FH provides protection against APAP-induced liver injury.
RESULTS
C2-FH inhibited the increase in serum alanine aminotransferase activity, aspartate aminotransferase activity and lactate dehydrogenase, and reduced liver tissue necrosis caused by APAP. Moreover, it attenuated the inflammatory response and inhibited complement activation in APAP-induced liver injury. RNA-Seq analysis provided additional explanations for the protective role of C2-FH against APAP-induced liver injury.
CONCLUSION
C2-FH attenuates APAP-induced liver injury by inhibiting complement activation.
Performance and cholesterol of quail egg yolks fed with rice bran raw material with mangosteen peel flour enrichment
Authors: Ralahalu Tabita Naomi , Fredriksz Shirley , Matatula Michel J. 
Published: October 2024

This study aimed to examine the use of rice bran with enriched mangosteen rind in feed on the performance and cholesterol of quail egg yolks. The cage as a research tool was modified with ram wire on four sides, and a base with dimensions per box, length 59 cm, width 55 cm, height and base 30 cm. 15 food containers made of zinc measuring 48 x 6 x 6 cm were placed outside the cage. Using 15 bottles plastic at 800cc brand Medion as drinking bottles, Harnic HL3650 digital scales with an accuracy 1 gram for weighing feed, and HWH DJ602B digital scales with an accuracy of 0.01 gram for weighing eggs. The study used a completely randomized design with 3 treatments and 5 replications, with ten quails in each unit. The treatments tested were DP0 = control feed, DP1 = feed plus rice bran enriched with mangosteen peel flour without storage, and DP2 = feed plus rice bran enriched with mangosteen peel flour which is stored for 1 month. The mean differences between treatments were analyzed using the BNT test. The variables observed were feed intake, body weight gain, feed conversion, and egg yolk cholesterol. The results showed that the treatment given was significantly different (P<0.05) on feed intake, while body weight gain, feed conversion, and egg yolk cholesterol were not significantly different (P>0.05). The amount of feed consumed by quail fed rice bran with enriched mangosteen peel flour had different responses. The smallest amount consumed was found in the DP1 test feed. However, regarding weight gain, feed conversion and egg yolk cholesterol, the experimental feed did not show a good response. Homemade feed is 40.9% more expensive than commercial BR I broiler chicken feed.
Mediasi Pemberdayaan Psikologis pada Pengaruh Kepemimpinan Pemberdayaan terhadap Berbagi Pengetahuan
Authors: Handayani Ririn , Fawzi Rizky , Bastian Adolf 
Published: October 2024

This study uses a quantitative method with a descriptive and explanatory survey approach. The study was conducted at the Kampar Regency Land Office, with the aim of testing the mediation effect of empowerment leadership on the relationship between psychological empowerment and knowledge sharing. The population of this study consisted of all employees of the Kampar Regency Land Office, with a total of 144 people. Based on this population size, according to the Krejcie and Morgan (1970) table, the sample size for this study was 103 people. The sampling method used in this study was Systematic Random Sampling. All respondents will be used to obtain primary data related to the variables, which will be collected through a questionnaire with a Likert scale of 1-5 points. All data obtained will be analyzed using Structural Equation Modeling (SEM) with the Smart PLS 3.0 analysis tool. This study found that (a). empowerment leadership has a significant positive effect on knowledge sharing; (b). empowerment leadership has a significant positive effect on psychological empowerment; (c). psychological empowerment has a significant positive effect on knowledge sharing; (d). psychological empowerment mediates the effect of empowerment leadership on knowledge sharing.

This study uses a quantitative method with a descriptive and explanatory survey approach. The study was conducted at the Kampar Regency Land Office, with the aim of testing the mediation effect of empowerment leadership on the relationship between psychological empowerment and knowledge sharing. The population of this study consisted of all employees of the Kampar Regency Land Office, with a total of 144 people. Based on this population size, according to the Krejcie and Morgan (1970) table, the sample size for this study was 103 people. The sampling method used in this study was Systematic Random Sampling. All respondents will be used to obtain primary data related to the variables, which will be collected through a questionnaire with a Likert scale of 1-5 points. All data obtained will be analyzed using Structural Equation Modeling (SEM) with the Smart PLS 3.0 analysis tool. This study found that (a). empowerment leadership has a significant positive effect on knowledge sharing; (b). empowerment leadership has a significant positive effect on psychological empowerment; (c). psychological empowerment has a significant positive effect on knowledge sharing; (d). psychological empowerment mediates the effect of empowerment leadership on knowledge sharing.
Pengaruh Payment Method, Sosial Media Marketing, Dan Online Customer Review Terhadap Purchase Desicion Produk Fashion Di Shopee
Authors: Rofika Ulya , Arifin Samsul 
Published: October 2024

Penelitian ini bertujuan untuk Menganalisis pengaruh payment method terhadap purchase desicion produk fashion di Shopee. Menganalisis pengaruh sosial media marketing terhadap purchase desicion produk fashion di Shopee. Menganalisis pengaruh online customer review terhadap purchase desicion produk fashion di Shopee. Menganalisis pengaruh payment method, Sosial Media marketing, dan online customer review terhadap purchase desicion produk fashion di Shopee. Penelitian ini mengguankan penelitian kuantitatif dengan jumlah sampel sebanyak 102 responden. Hasil penelitian ini menunjukkan bahwa Secara parsial Payment method tidak berpengaruh terhadap Purchase Decision. Secara parsial Sosial Media marketing dan Online customer review berpengaruh signifikan terhadap Purchase Decision dan Secara simultan payment method, Sosial Media marketing, dan online customer review berpengaruh signifikan terhadap terhadap purchase desicion produk fashion di Shopee terlihat dari hasil uji ANOVA bahwa nilai F hitung mempunyai nilai sebesar 17.269 sedangkan nilai F tabelnya sebesar 2.69 kemudian didapat nilai signifikansi sebesar 0.000 yang mana lebih kecil dari taraf signifikansinya sebesar 0.05.
Pengaruh Transformasi Digital Terhadap Peningkatan Kinerja Karyawan pada UMKM Songket Kota Palembang
Authors: Imelda Imelda , Aliya Sabeli 
Published: October 2024

This study aims to examine the impact of digital transformation on enhancing employee performance in songket SMEs in Palembang City. A quantitative research method was employed, with data gathered through the distribution of questionnaires using purposive sampling. The population comprised 100 individuals, including managers and employees of songket SMEs in Palembang City, from which 80 respondents were selected based on Slovin’s formula. Data analysis was conducted using SEM-PLS. The findings revealed that digital transformation has a statistical value of 2.442, exceeding the critical value of 1.96, indicating a positive and significant effect on the performance of songket SME employees in Palembang City. With the effective adoption of technology, employees can work more efficiently, overcome challenges more adeptly, and produce higher-quality outcomes. Therefore, for the songket SMEs in Palembang City, continuing and expanding the use of digital technology represents a crucial strategic move to boost performance and enhance competitiveness in the marketplace.
Keywords: Digital Transformation, Employee performances, SMEs

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh transformasi digital terhadap peningkatan kinerja karyawan UMKM songket di Kota Palembang. Penelitian ini menggunakan metode kuantitatif. Teknik pengumpulan data melalui distribusi kuesioner, dengan menggunakan teknik purposive sampling. Jumlah populasi sebanyak 100 orang yang terdiri dari pengelola dan karyawan UMKM Songket kota Palembang, diambil 80 responden yang dihitung menggunakan rumus Slovin. Teknik analisis data menggunakan SEM-PLS. Hasil penelitian ini menunjukkan bahwa berdasarkan nilai statistik transformasi digital terhadap kinerja karyawan Songket Kota Palembang memiliki nilai statistik 2,442 > 1,96 sehingga dapat dinyatakan variabel transformasi digital berpengaruh secara positif dan signifikan terhadap kinerja karyawan Songket Kota Palembang. Dengan adopsi teknologi yang tepat, karyawan UMKM songket dapat bekerja dengan lebih efisien, menghadapi tantangan dengan lebih baik, dan menghasilkan output yang lebih berkualitas. Oleh karena itu, bagi UMKM songket di Kota Palembang, melanjutkan dan memperluas penggunaan teknologi digital menjadi langkah strategis yang penting untuk meningkatkan kinerja dan daya saing di pasar
Pengaruh Pengembangan Karir dan Fasilitas Kerja Terhadap Kepuasan Kerja Karyawan pada PT. Sucofindo Palembang
Authors: Elvina Indria , Aliya Sabeli 
Published: October 2024

This study aims to investigate the influence of career development and workplace facilities on employee job satisfaction at PT. Sucofindo Palembang. The research employs a population approach with a total sampling technique. Data were collected through questionnaires distributed to 50 respondents. The study uses a quantitative method with an associative causal explanation. Data analysis includes data quality testing, classical assumption tests, multiple linear regression analysis, coefficient of determination, and hypothesis testing. The results show a positive impact of career development and workplace facilities on employee job satisfaction at PT. Sucofindo Palembang, both individually and collectively.

Keywords: Career development, Workplace facilities, Employee job satisfaction

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh pengembangan karir dan fasilitas kerja terhadap kepuasan kerja karyawan di PT. Sucofindo Palembang. Penelitian ini menggunakan pendekatan populasi dengan teknik total sampling. Data dikumpulkan melalui kuesioner yang dibagikan kepada 50 responden. Metode penelitian yang digunakan adalah kuantitatif dengan penjelasan asosiatif kausal. Analisis data yang dilakukan meliputi uji kualitas data, uji asumsi klasik, analisis regresi linear berganda, uji koefisien determinasi, dan uji hipotesis. Hasil penelitian menunjukkan adanya pengaruh positif dari variabel pengembangan karir dan fasilitas kerja terhadap kepuasan kerja karyawan di PT. Sucofindo Palembang, baik secara parsial maupun simultan.
Caring in crisis: addressing patient safety, burnout, and long hours in healthcare
Authors: Shaheen Fabeeha , Shaheen Qareena 
Published: October 2024

Madam,
The World Health Organization defines patient safety as preventing errors and adverse effects to patients associated with health care and “to do no harm to patients”. Specifically, in low and middle-income countries (LMICs), about 134 million adverse events occur each year due to unsafe care in hospitals, resulting in 2.6 million deaths annually. [1] Along with other determining factors, professional well-being, long hours, and burnout syndromes also influence patient care. [2] Burnout is a condition directly linked to workplace environment, stemming from occupational stress and extended working hours. Garcia, C.L. et al., through meta-analysis, found a relationship between the development of burnout and patient safety actions, with a probability of superiority of 66.4%. High levels of burnout and worsening patient safety are related to external factors such as high workload, long working hours, lack of a secure environment, and interpersonal relationships. [3]
These findings raise concerns, particularly in a country like Pakistan, where the extent of understaffing and high workload can be inferred from the following statistics: The doctor-to-population ratio in Pakistan was 1:1000 in 2018 [4]. In contrast, the doctor-to-population ratio in Malaysia was 2.2:1000 in 2018 [5]. As a result of this shortage, the current workforce in Pakistan is negatively affected. In a study by Kasi PM et al. on postgraduate trainees in Pakistan, individuals under stress were more likely to report longer working hours. This increased workload made them prone to medical errors, which ultimately undermines the patient safety culture. A study conducted at a tertiary care hospital in Pakistan using the Hospital Survey on Patient Safety Culture (HSOPSC) compared the benchmarks from hospitals in the USA and discovered that high staff workload is a significant concern among staff [6]
In Pakistan, where healthcare resources are limited, fostering a culture of effective work-hour management and breaks is essential for creating a healthier and safer environment for health professionals and patients. Ensuring adequate staffing levels to distribute the workload and prevent overburdening is essential. Providing designated areas for relaxation, offering mental health resources and mindfulness programmes like yoga or meditation can help doctors to cope with stress. Furthermore, promoting a culture of multidisciplinary teamwork, a mentorship program, and effective handover protocols during shift changes can ensure continuity of care. Medical institutes should invest in technology that can streamline administrative tasks and reduce paperwork burden.
---Continue
Challenging antibiotic stewardship: antibiotic use in the management of acute pancreatitis without waiting for a CT scan or CRP marker
Authors: Rubyisha Sheikh  , Zain Ul Abideen  , Hassan Waseem  
Published: October 2024

Madam,
Acute pancreatitis is an acute inflammation of the pancreas presenting as severe abdominal pain and elevated pancreatic enzymes. The global burden of Acute pancreatitis has increased by 3.07% per year, for the last 56 years.1 Gallstones, chronic alcohol, and hypertriglyceridemia are the main risk factors involved in the pathogenesis of Acute pancreatitis worldwide.2 However, in Pakistan gall stones impacting the common bile duct and hypertriglyceridemia are the main culprits.
There has been an extensive debate regarding the use of prophylactic antibiotics and the outcome of acute pancreatitis. The cumulative evidence suggests that the prompt use of antibiotics, before obtaining serum markers, is not associated with a significant decrease in secondary pancreatic infection.3
Multiple studies have shown that the use of antibiotics, deviating from the recent guidelines, boosts antibiotic resistance and the risk of invasive fungal infections. A 2020 study conducted by Soulountsi has also rendered this practice unjustified.4
In studies supporting the use of prophylactic antibiotics in improving outcomes, the quality of evidence is low suggesting that the approach should be more tailored to individual patient conditions while adhering to the guidelines. Despite the sterile nature of the early stages of acute pancreatitis, some clinicians continue to opt for prophylactic use, however, it is strictly against the international consensus. Unfortunately, in Pakistan, there is a common practice of using antibiotics in acute pancreatitis within 72hrs, without waiting for the CT scan results and inflammatory markers screening.
Antimicrobial resistance is an anticipated outcome of such practice. The prevalence of antimicrobial resistance to commonly prescribed antibiotics is already very high.5 Not weighing the risk-benefit ratio will not only contribute to increasing resistance but also predispose to avoidable and potentially fatal fungal infections. The appropriate approach to management of Acute pancreatitis should be based on a thorough knowledge of recent guidelines, carrying out proper investigations, and making an individualized plan for the patient based on clinical findings. This will not only minimize the burden of complications but also provide more room for improvements in the management of acute pancreatitis.