bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of genetic variants with fatigue in patients with malignant glioma
Authors: Armstrong Terri S , Vera Elizabeth , Zhou Renke , Acquaye Alvina A , Sullaway Catherine M , Berger Ann M , Breton Ghislain , Mahajan Anita , Wefel Jeffrey S , Gilbert Mark R , Bondy Melissa , Scheurer Michael E 
Published: September 2017

AbstractBackgroundFatigue is a consistently reported, severe symptom among patients with gliomas throughout the disease trajectory. Genomic pathways associated with fatigue in glioma patients have yet to be identified.MethodsClinical factors (performance status, tumor details, age, gender) were collected by chart review on glioma patients with fatigue (“I have lack of energy” on Functional Assessment of Cancer Therapy-Brain), as well as available genotyping data. Candidate genes in clock and inflammatory pathways were identified from a literature review, of which 50 single nucleotide polymorphisms (SNPs) in 7 genes were available. Clinical factors and SNPs identified by univariate analyses were included in a multivariate model for moderate-severe fatigue.ResultsThe study included 176 patients (median age = 47 years, 67% males). Moderate-severe fatigue was reported by 43%. Results from multivariate analysis revealed poor performance status and 2 SNPs were associated with fatigue severity. Moderate-severe fatigue was more common in patients with poor performance status (OR = 3.52, P < .01). For each additional copy of the minor allele in rs934945 (PER2) the odds of fatigue decreased (OR = 0.51, P < .05). For each additional copy of the minor allele in rs922270 (ARTNL2) the odds of fatigue increased (OR = 2.38, P < .01). Both of these genes are important in the circadian clock pathway, which has been implicated in diurnal preference, and duration and quality of sleep. No genes in the inflammatory pathway were associated with fatigue in the current study.ConclusionsIdentifying patients at highest risk for fatigue during treatment allows for improved clinical monitoring and enrichment of patient selection for clinical trials.
Ongoing HIV Replication During ART Reconsidered
Authors: Kearney Mary F , Wiegand Ann , Shao Wei , McManus William R , Bale Michael J , Luke Brian , Maldarelli Frank , Mellors John W , Coffin John M 
Published: September 2017

Abstract
Lorenzo-Redondo et al. recently analyzed HIV RNA sequences in plasma virus and proviral DNA sequences in lymph nodes (LN) and peripheral blood mononuclear cells (PBMC) from samples collected over a 6-month period from 3 individuals following initiation of antiretroviral therapy (ART) and concluded that ongoing HIV replication occurred in LN despite ART and that this replication maintained the HIV reservoir. We analyzed the same sequences and found that the dataset was very limited (median of 5 unique RNA or DNA sequences per sample) after accounting for polymerase chain reaction resampling and hypermutation and that the few remaining DNA sequences after 3 and 6 months on ART were not more diverse or divergent from those in pre-ART in any of the individuals studied. These findings, and others, lead us to conclude that the claims of ongoing replication on ART made by Lorenzo-Redondo et al. are not justified from the dataset analyzed in their publication.
Encouraging Reflexivity in a Residency Leadership Development Program: Expanding Outside the Competency Approach
Authors: Clapp Justin T. , Gordon Emily K.B. , Baranov Dimitry Y. , Trey Beulah , Tilin Felice J. , Fleisher Lee A. 
Published: September 2017

Problem
While leadership development is increasingly a goal of academic medicine, it is typically framed as competency acquisition, which can limit its focus to a circumscribed set of social behaviors. This orientation may also reinforce the cultural characteristics of academic medicine that can make effective leadership difficult, rather than training leaders capable of examining and changing this culture. Expanding leadership development so it promotes social reflexivity presents a way to bolster some of the weaknesses of the competency paradigm.

Approach
In 2013–2016, the University of Penn sylvania’s Department of Anesthesiology and Critical Care (DACC) carried out a leadership development program for residents, which included seminars focused on developing particular leadership skills and annual capstone sessions facilitating discussion between residents and attending physicians about topics chosen by residents. The capstone sessions proved to be most impactful, serving as forums for open conversation about how these groups interact when engaged in social behaviors such as giving/receiving feedback, offering support after an adverse event, and teaching/learning in the clinic.

Outcomes
The success of the capstone sessions led to a 2016 DACC-wide initiative to facilitate transparency among all professional roles (faculty, residents, nurse anesthetists, administrative staff) and encourage widespread reflexive examination about how the manner in which these groups interact encourages or impedes leadership and teamwork.

Next Steps
Further work is necessary to describe how leadership program formats can be diversified to better encourage reflexivity. There is also a need to develop mechanisms for assessing outcomes of leadership programs that expand outside the competency-based system.
Patients’ and Clinicians’ Views of the Psychological Components of Tinnitus Treatment That Could Inform Audiologists’ Usual Care: A Delphi Survey
Authors: Thompson Dean M. , Taylor John , Hall Deborah A. , Walker Dawn-Marie , McMurran Mary , Casey Amanda , Stockdale David , Featherstone Debbie , Hoare Derek J. 
Published: September 2017

Objectives:
The aim of this study was to determine which components of psychological therapies are most important and appropriate to inform audiologists’ usual care for people with tinnitus.

Design:
A 39-member panel of patients, audiologists, hearing therapists, and psychologists completed a three-round Delphi survey to reach consensus on essential components of audiologist-delivered psychologically informed care for tinnitus.

Results:
Consensus (≥80% agreement) was reached on including 76 of 160 components. No components reached consensus for exclusion. The components reaching consensus were predominantly common therapeutic skills such as Socratic questioning and active listening, rather than specific techniques, for example, graded exposure therapy or cognitive restructuring. Consensus on educational components to include largely concerned psychological models of tinnitus rather than neurophysiological information.

Conclusions:
The results of this Delphi survey provide a tool to develop audiologists’ usual tinnitus care using components that both patients and clinicians agree are important and appropriate to be delivered by an audiologist for adults with tinnitus-related distress. Research is now necessary to test the added effects of these components when delivered by audiologists.
Breast Reduction: Decreasing Complications and Improving Long-Term Aesthetic Results with Parenchymal Sutures
Authors: Hudson Donald Anthony , Moodley Sean 
Published: September 2017

Background:
The inverted T/keyhole pattern is commonly used for large breast reductions. This technique relies on the breast skin to retain the shape. With the passage of time “fallout” (pseudoptosis) occurs impairing the cosmetic result. A technique is described that uses parenchymal sutures and inframammary fold (IMF) reinforcement sutures to maintain the intraoperative shape.

Methods:
A retrospective study of 25 consecutive patients (50 breasts) where the IMF was reinforced and parenchymal sutures were inserted. The patients were followed up and the nipple to notch and nipple to IMF distance was measured and compared with that marked preoperatively and set intraoperatively. Complications, especially T junction breakdown, were also recorded.

Results:
The mean age was 38 years (range, 16–62 years) with a mean follow-up of 12 months. The mean body mass index was 31 (range, 22–41). The mean mass of tissue excised was 925 g (range, 340–1,800 g) per side. The distance from the suprasternal notch to the nipple remained unchanged. The distance from the nipple to the IMF remained the same as that marked preoperatively except in 3 patients who developed pseudoptosis. Only 3 patients had wound dehiscence.

Conclusion:
Parenchymal and superficial fascial system sutures combined with IMF reinforcement contributes to maintaining the aesthetic result and decreasing complications, in weight stable patients.
Retrospective Evaluation of the Impact of a Geriatric Trauma Institute on Fragility Hip Fracture Patient Outcomes
Authors: Katrancha Elizabeth D. , Zipf Jami , Abrahams Nancy , Schroeder Richard 
Published: September 2017

BACKGROUND:
Fragility hip fractures occur in the older than 65-year population at an alarming rate. It is estimated that 260,000 hip fractures occur annually. Patient outcomes following hip fractures are devastating. One of every 5 patients dies within 1 year of injury, and 1 of 3 remains in a nursing home for years after the injury. Published literature recommends an interdisciplinary approach to caring for hip-fractured patients and expediting surgery to improve outcomes.

PURPOSE:
The purpose of this study was to retrospectively evaluate the impact of the Geriatric Trauma Institute (GTI) on fragility hip fracture patient outcomes. Specific outcomes included length of stay (LOS), length of time from emergency department (ED) arrival to operating room (OR), complication rate, and discharge destination.

METHODS:
This study is a single-center pre- and post-retrospective chart review. Data were collected using database queries within the hospital system. Pre-GTI (n = 326) patients older than 65 years with International Classification of Disease, Ninth Revision (ICD-9) codes 820.0–820.9 (hip fractures) admitted to either a primary care physician or orthopaedic surgeon service between April 1, 2011, and April 1, 2013, were compared with post-GTI (n = 245) patients older than 65 years with ICD-9 codes 820.0–820.9 (hip fractures) admitted to trauma services (GTI) between May 1, 2013, and May 1, 2015. Descriptive statistics including demographic data (age, sex) and comparison of outcomes (LOS, ED to OR time, complications, and disposition) across the groups using standard analysis of variance (ANOVA) and correlation techniques.

RESULTS:
No statistical difference was found between groups for age, sex, or time from ED to OR pre- versus post-time period using one-way ANOVA, F(1,569) = 1.08, p = .30. The complication rate was calculated pre- and post-GTI and compared using the 2-proportion z-test. The difference between the pre-GTI group (16.6%; 54 of 326 patients) and the post-GTI group (9.4%; 23 of 245 patients) was statistically significant, p = .013. Mean LOS was statistically significantly higher in the pre-GTI group (M = 5) than in the post-GTI group (M = 5.2), U = 33,55, z = −3.32, p = .001. No statistical significance was found between pre- and postdischarge destination, χ2(4) = .4.82, p = .307; likelihood ratio test, χ2(4) = .5.19, p = .269.

CONCLUSIONS:
This retrospective pre- and post-GTI chart review demonstrates the effectiveness of a multidisciplinary team approach in decreasing complications and LOS for fragility hip-fractured patients. A team approach to the care of these patients improves outcomes and quality of life.
The Protective Effect of A Short Peptide Derived From Cold-Inducible RNA-Binding Protein in Renal Ischemia–Reperfusion Injury
Authors: McGinn Joseph , Zhang Fangming , Aziz Monowar , Yang Weng-Lang , Nicastro Jeffrey , Coppa Gene F. , Wang Ping 
Published: September 2017

ABSTRACT
Extracellular cold-inducible RNA-binding protein (CIRP) functions as damage-associated molecular pattern and has been demonstrated to be responsible in part for the damage occurring after renal ischemia–reperfusion (I/R). A short peptide derived from CIRP, named C23, binds to myeloid differentiation factor 2, a Toll-like receptor 4 coreceptor. We hypothesize that C23 reduces renal ischemia–reperfusion (RIR) injury by blocking CIRP. We observed that pretreatment with C23 significantly decreased the levels of recombinant mouse CIRP-induced tumor necrosis factor-α (TNF-α) in a dose-dependent fashion in cultured macrophages. C57BL/6 mice were subjected to bilateral renal pedicle clamps for 35 min to induce ischemia, followed by reperfusion for 24 h and harvest of blood and renal tissue. C23 peptide (8 mg/kg) or vehicle was injected intraperitoneally at the beginning of reperfusion. Plasma TNF-α, interleukin 1 beta (IL-1β), and IL-6 levels were decreased in C23-treated RIR mice as compared with vehicle-treated mice by 74%, 85%, and 68%, respectively. Expressions of TNF-α and keratinocyte chemoattractant in the kidneys from C23-treated mice were decreased by 55% and 60%, respectively. Expression of kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in the kidney of C23-treated mice were significantly reduced by 46% and 55%, respectively. Renal tissue histological assessments revealed significant reduction in damage score by 44% in C23-treated mice. Finally, a survival study revealed a significant survival advantage with a 70% survival rate in C23 group vs. 37% in vehicle group. Thus, C23 has potential as a novel therapy for the patients suffering from I/R-induced renal injury.
Luminous blue variables and the fates of very massive stars
Authors: Smith Nathan 
Published: September 2017

Luminous blue variables (LBVs) had long been considered massive stars in transition to the Wolf–Rayet (WR) phase, so their identification as progenitors of some peculiar supernovae (SNe) was surprising. More recently, environment statistics of LBVs show that most of them cannot be in transition to the WR phase after all, because LBVs are more isolated than allowed in this scenario. Additionally, the high-mass H shells around luminous SNe IIn require that some very massive stars above 40
M
⊙
die without shedding their H envelopes, and the precursor outbursts are a challenge for understanding the final burning sequences leading to core collapse. Recent evidence suggests a clear continuum in pre-SN mass loss from super-luminous SNe IIn, to regular SNe IIn, to SNe II-L and II-P, whereas most stripped-envelope SNe seem to arise from a separate channel of lower-mass binary stars rather than massive WR stars.

This article is part of the themed issue ‘Bridging the gap: from massive stars to supernovae’.
The direct identification of core-collapse supernova progenitors
Authors: Van Dyk Schuyler D. 
Published: September 2017

To place core-collapse supernovae (SNe) in context with the evolution of massive stars, it is necessary to determine their stellar origins. I describe the direct identification of SN progenitors in existing pre-explosion images, particularly those obtained through serendipitous imaging of nearby galaxies by theHubble Space Telescope. I comment on specific cases representing the various core-collapse SN types. Establishing the astrometric coincidence of a SN with its putative progenitor is relatively straightforward. One merely needs a comparably high-resolution image of the SN itself and its stellar environment to perform this matching. The interpretation of these results, though, is far more complicated and fraught with larger uncertainties, including assumptions of the distance to and the extinction of the SN, as well as the metallicity of the SN environment. Furthermore, existing theoretical stellar evolutionary tracks exhibit significant variations one from the next. Nonetheless, it appears fairly certain that Type II-P (plateau) SNe arise from massive stars in the red supergiant phase. Many of the known cases are associated with subluminous Type II-P events. The progenitors of Type II-L (linear) SNe are less established. Among the stripped-envelope SNe, there are now a number of examples of cool, but not red, supergiants (presumably in binaries) as Type IIb progenitors. We appear now finally to have an identified progenitor of a Type Ib SN, but no known example yet for a Type Ic. The connection has been made between some Type IIn SNe and progenitor stars in a luminous blue variable phase, but that link is still thin, based on direct identifications. Finally, I also describe the need to revisit the SN site, long after the SN has faded, to confirm the progenitor identification through the star's disappearance and potentially to detect a putative binary companion that may have survived the explosion.This article is part of the themed issue ‘Bridging the gap: from massive stars to supernovae’.
Accurate Genomic Prediction Of Human Height
Authors: Lello Louis , Avery Steven G. , Tellier Laurent , Vazquez Ana I. , de los Campos Gustavo , Hsu Stephen D. H. 
Published: September 2017

AbstractWe construct genomic predictors for heritable and extremely complex human quan-titative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). Replication tests show that these predictors capture, respectively, ∼40, 20, and 9 percent of total variance for the three traits. For example, predicted heights correlate ∼0.65 with actual height; actual heights of most individuals in validation samples are within a few cm of the prediction. The variance captured for height is comparable to the estimated SNP heritability from GCTA (GREML) analysis, and seems to be close to its asymptotic value (i.e., as sample size goes to infinity), suggesting that we have captured most of the heritability for the SNPs used. Thus, our results resolve the common SNP portion of the “missing heritability” problem – i.e., the gap between prediction R-squared and SNP heritability. The ∼20k activated SNPs in our height predictor reveal the genetic architecture of human height, at least for common SNPs. Our primary dataset is the UK Biobank cohort, comprised of almost 500k individual genotypes with multiple phenotypes. We also use other datasets and SNPs found in earlier GWAS for out-of-sample validation of our results.
Climate change adaptation-disaster risk reduction nexus: case study from Ethiopia
Authors: Gebreyes Million , Tesfaye Kindie , Feleke Beneberu 
Published: September 2017

Purpose
The recently released fifth IPCC report indicates a high agreement among global actors on the need to integrate climate change adaptation (CCA) and disaster risk reduction (DRR). However, there remains little local level evidence on how DRR and CCA could be linked, the sorts of adjustments that are required for the two concepts to be integrated and the challenges ahead. This paper aims to provide an empirical insight on the possible links and departures between DRR and CCA.

Design/methodology/approach
The study used a qualitative case study approach to excavate lessons from an existing DRR intervention for CCA using a local-level adaptive capacity assessment framework as a normative criteria. Data was collected both from primary and secondary sources. The primary data collection involved the use of participatory rural appraisal techniques with village communities in Chifra District, Afar Regional State, Ethiopia.

Findings
The findings showed that the DRR interventions studied addressed parts of the elements of adaptive capacity at the local level. The findings also showed the limitation of the DRR intervention, which could be attributed to both the nature of the DRR interventions in general and implementation problems of the case study intervention in particular. The limitations show cases where full integration of DRR with CCA could be challenging.

Originality/value
The paper argues why the two approaches may not be integrated fully and also shows the need to focus on the design of DRR interventions in achieving both short-term (reducing disaster risks) and long-term objectives (enhancing adaptive capacity).
Social protection as a strategy to address climate-induced migration
Authors: Schwan Susanne , Yu Xiaohua 
Published: September 2017

PurposeThis paper aims to discuss the roles of social protection in reducing and facilitating climate-induced migration. Social protection gained attention in the international climate negotiations with the establishment of the Warsaw International Mechanism for Loss and Damage. Yet, its potential to address migration, considered as a key issue in the loss and damage debate, has not been sufficiently explored. This paper aims at identifying key characteristics of social protection schemes which could effectively address climate-induced migration and attempts to derive recommendations for policy design.Design/methodology/approachBased on the existing literature, the paper links empirical evidence on the effects of social protection to climate-related drivers of migration and the needs of vulnerable populations. This approach allows conceptually identifying characteristics of effective social protection policies.FindingsFindings indicate that social protection can be part of a proactive approach to managing climate-induced migration both in rural and urban areas. In particular, public work programmes offer solutions to different migration outcomes, from no to permanent migration. Benefits are achieved when programmes explicitly integrate climate change impacts into their design. Social protection can provide temporary support to facilitate migration,in situadaptation or integration and adaptation in destination areas. It is no substitution for but can help trigger sustainable adaptation solutions.Originality/valueThe paper helps close research gaps regarding the potential roles and channels of social protection for addressing and facilitating climate-induced migration and providing public support in destination, mostly in urban areas.
Identification of sustainable expansion alternatives for heterogeneous grid topologies
Authors: Lühn Tobias , Schmidtmann Genoveva , Geldermann Jutta 
Published: September 2017

Purpose
The aim of this paper is to introduce a newly developed multi-criteria analysis for the comparison of two grid expansion alternatives, conventional and voltage-regulated distribution transformer. The case study comprises environmental, economic, technical and social aspects.

Design/methodology/approach
The newly developed method decision condition Preference Ranking Organization METHod for Enrichment Evaluation (DC-PROMETHEE) combines scenario planning with the multi-attribute decision-making method PROMETHEE. DC-PROMETHEE supports the decision-maker to evaluate the total potential of an alternative considering a large number of decision conditions. The calculated performance indicator supports the decision-maker to select the best alternative.

Findings
The voltage-regulated distribution transformer shows a high overall potential in the present case study. This leads to the recommendation to the investigated distribution system operator to include the voltage-regulated distribution transformers as a grid expansion measure.

Practical implications
The DC-PROMETHEE can be applied to other distribution system operators by considering their individual grid topology and preferences. Other fields of application are infrastructure investments in the service area, in which expansion alternatives are evaluated in a large number of decision conditions. Examples include telecommunication, gas supply, water supply, sewage and rail networks.

Originality/value
This paper develops the DC-PROMETHEE approach. The DC-PROMETHEE enables the multi-criteria evaluation of a few alternatives in a large number of decision conditions.