bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Asymmetric Orthogonal Arrays of Strength Three via a Replacement Method
Authors: Zhang Tian‐fang , Deng Qiaoling , Dey Aloke 
Published: March 2017

AbstractA replacement procedure to construct orthogonal arrays of strength three was proposed by Suen et al. [7]. This method was later extended by Suen and Dey [8]. In this paper, we further explore the replacement procedure to obtain some new families of orthogonal arrays of strength three.
Simultaneous production of C‐phycocyanin and extracellular polymeric substances by photoautotrophic cultures of Arthrospira platensis
Authors: Dejsungkranont Monchai , Chisti Yusuf , Sirisansaneeyakul Sarote 
Published: March 2017

AbstractBACKGROUNDArthrospira platensis produces the blue pigment C‐phycocyanin (C‐PC) and extracellular polymeric substances (EPS) of potential value in food and pharmaceutical applications.RESULTSBatch cultures were used to simultaneously produce C‐PC and EPS. The effects of incident light level on growth and product formation are reported. A maximum biomass concentration of 1.5 g L−1 in 14 days was obtained at a light intensity of 203 µmol m−2 s−1. The light intensity affected the biomass composition and the production of the two products. Protein, phenolic compounds and chlorophyll a in the biomass were reduced at high light levels, but carbohydrate and the total carotenoids were increased. Production of C–PC was growth associated. The highest concentration of C–PC in the culture broth was ∼60 mg L−1 at a photon flux of 135 µmol m−2 s−1. EPS was produced mostly in the stationary phase. The highest EPS concentration of ∼960 mg L−1 occurred at a photon flux of 203 µmol m−2 s−1. Incident light level also affected the antioxidant properties of the two products.CONCLUSIONIncident light strongly affected the production of C‐PC, EPS and the biomass composition. Low light favored C‐PC production whereas high light favored the production of EPS. © 2017 Society of Chemical Industry
Northern bobwhite habitat use in a food subsidized pyric landscape
Authors: McGrath Diana J. , Terhune Theron M. , Martin James A. 
Published: March 2017

ABSTRACTAnimals inhabiting disturbance‐prone systems, such as the northern bobwhites (Colinus virginianus) in pine (Pinus spp.) savanna, are adapted to certain intensities of disturbance (e.g., frequency, spatial extent, seasonality). Management practices attempt to mimic these natural conditions. Even though northern bobwhites are known as the firebird, most fire‐related management is currently based on tradition and limited peer‐reviewed literature. We studied habitat selection of northern bobwhites on private property in Georgetown County, South Carolina, USA, managed with fire, winter disking, and supplemental feeding. We radio‐tagged 338 individual bobwhites and monitored them 3–4 times weekly via very high frequency (VHF) telemetry for 2 years. We used hierarchical habitat selection functions in a Bayesian framework to model the data. We considered 2 spatial scales: the study site (second‐order) and within home ranges (third‐order). Bobwhites selected for small burns during the breeding season but had the highest selection for areas intermediately distant from burn edges during winter (i.e., 67 m). Bobwhites had the strongest selection for fire return intervals of 2–3 years during winter but 1–2 years during the breeding season. Use of supplemental feed was strong across seasons but not selected for by brooding birds within their home range. Use of fallow fields was strongest for brooding birds. Our results are useful for bobwhite managers, especially those in subtropical climates, because they provide scientifically defensible information supporting the use of prescribed fire, winter disking, and supplemental feeding in the context of habitat use. © 2017 The Wildlife Society.
Are new approaches needed for developing long‐term strategies for STEM information?
Authors: Brown David 
Published: March 2017

Key points

Trends point to increased democratization within STEM, driven by open access, Internet delivery, and digital natives.
The current journal publishing system does not meet the needs of researchers who want timely access to the latest results.
Demographic and sociological changes are likely to undermine the inherent conservatism of STEM.
Traditional STEM systems ignore the latent market of knowledge workers, but new information services do not.
Radical approaches to STEM are required if we are to respond to the ‘perfect storm’ of changing needs and expectations.
New microstructured chromium doped poly(p‐toluidine) as a new acid–base indicator and precursor for chromic oxide nanostructured
Authors: Zoromba M.Sh. , Abdel‐Aziz M.H. , Bassyouni M. 
Published: March 2017

New chromium doped poly(p‐toluidine) (Cr‐PPT) was synthesized via chemical oxidative polymerization of p‐toluidine with potassium dichromate as an initiator in acidic aqueous medium. The spectrophotometric behavior of Cr‐PPT in acetone and chloroform as different solvents was investigated. Cr‐PPT exhibits bathochromically red shift at 46‐nm value with the increasing of solvent polarity. The intermolecular charge transfer band peak for Cr‐PPT shifted from 422 nm in low‐polar solvent (chloroform) to high‐polar solvent (acetone) to 468 nm. Optical absorption measurements are used to obtain the energy gap of prepared Cr‐PPT. Cr‐PPT has an optical band gap (Eg = 1.90 to 2.05 eV) that is located in the semiconductor range. Pink color was observed using Cr‐PPT solution in acidic media while it changes sharply to yellow in basic medium. Based on intermolecular charge transfer, the Cr‐PPT was used as acid–base indicator. Cr‐PPT and phenolphthalein (phph) indicator were used for determination of normality of HCl using standard 0.1 N NaOH, the two indicators gave equal end point values. Using Cr‐PPT as a new molecular precursor for the production chromium oxide in nanoscale by thermal decomposition route was studied, and the average size of synthesized Cr2O3 was found in the range of 54–61 nm. Copyright © 2017 John Wiley & Sons, Ltd.
Functional diversity of Arabidopsis organelle‐localized RNA‐recognition motif‐containing proteins
Authors: Shi Xiaowen , Hanson Maureen R. , Bentolila Stephane 
Published: March 2017

RNA‐Binding Proteins (RBPs) play key roles in plant gene expression and regulation. RBPs contain a variety of RNA‐binding motifs, the most abundant and most widespread one in eukaryotes is the RNA recognition motif (RRM). Many nucleus‐encoded RRM‐containing proteins are transported into chloroplasts and/or mitochondria, and participate in various RNA‐related processes in plant organelles. Loss of these proteins can have a detrimental effect on some critical processes such as photosynthesis and respiration, sometimes leading to lethality. Progress has been made in the last few years in understanding the function of particular organelle‐localized RRM‐containing proteins. Members of the Organelle RRM protein (ORRM, some also characterized as Glycine‐Rich RNA‐Binding Proteins) family and the Chloroplast RiboNucleoProtein (cpRNP) family, are involved in various types of RNA metabolism, including RNA editing, RNA stability and RNA processing. Organelle‐localized RRM proteins also function in plant development and stress responses, in some conditions acting as protein or RNA chaperones. There has been recent progress in characterizing the function of organelle‐localized RRM proteins in RNA‐related processes and how RRM proteins contribute to the normal growth and development of plants. WIREs RNA 2017, 8:e1420. doi: 10.1002/wrna.1420This article is categorized under:

RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
The patient’s experience of primary ciliary dyskinesia: a systematic review
Authors: Behan Laura , Rubbo Bruna , Lucas Jane S. , Dunn Galvin Audrey 
Published: March 2017

Abstract
Background
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by progressive sinopulmonary disease, with symptoms starting soon after birth. The aim of this study is to critically review, analyse, and synthesise the literature in order to understand the experiences of patients with primary ciliary dyskinesia (PCD) and the impact on health-related quality of life.

Method
MEDLINE, EBSCO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO and EMBASE were searched according to the inclusion criteria. A qualitative analysis of 14 studies was conducted.

Results
Fourteen studies were included in the review, five with qualitative methodologies. Studies originated from the UK, USA, Italy, Denmark and Belgium, one study included a survey distributed internationally. Significant relationships were found between age and worsening of respiratory symptoms, physical, and mental domains of health-related quality of life, with a greater decline compared with reference populations. Variations between the UK and Italy were found for health-related quality of life and its correlation with time since diagnosis. PCD was found to have a physical impact in all age groups: patients found it difficult to keep up with others, and found energy levels were easily depleted compared to family or peers. In terms of social impact, symptoms lead to embarrassment and a sense of isolation, with patients concealing symptoms and/or their diagnosis. In turn, isolation was also linked with the lack of public and medical knowledge. In relation to emotional impact, anxiety was reported in a number of qualitative studies; patients were anxious about getting sick or when thinking about their future health. The burden of treatment and factors influencing adherence were also discussed in depth.

Conclusion
Health-related quality of life decreases with age in patients with PCD. For all age groups, PCD was found to greatly impact physical, emotional, social functioning, and treatment burden. More research is needed on the psychosocial impact of the illness, disease burden and its effect on quality of life.
Immunisation status and determinants of left-behind children aged 12–72 months in central China
Authors: NI Z.L. , TAN X.D , SHAO H.Y. , WANG Y. 
Published: March 2017

SUMMARYMany parents move from rural China to urban areas in search of job opportunities, and leave their children behind to be raised by relatives. We aimed to assess the immunisation coverage, including the 1:3:3:3:1 vaccine series (one dose of Bacilli Chalmette–Guérin vaccine; three doses of live attenuated oral poliomyelitis vaccine; three doses of diphtheria, tetanus and pertussis combined; three doses of hepatitis B vaccine; and one dose of measles-containing vaccine), in children aged 12–72 months and identify the determinants of immunisation uptake among left-behind children in Hubei Province, Central China, in 2014. In this cross-sectional study using the World Health Organization's cluster sampling technique, we surveyed 1368 children from 44 villages in 11 districts of Hubei Province. The socio-demographic and vaccination status data were collected by interviewing primary caregivers using a semi-structured questionnaire and reviewing the immunisation cards of the children. Univariate and multivariate analyses were used to identify the determinants of complete vaccination and age-appropriate vaccination. For each dose of the five vaccines, the vaccination coverage in the left-behind and non-left-behind children was >90%; however, the age-appropriate vaccination coverage for each vaccine was lower in left-behind than in non-left-behind children. For the five vaccines, the fully vaccinated rate of left-behind children were lower than those of non-left-behind children (89·1%, 92·7%;P= 0·013) and age-appropriate immunisation rate of left-behind children were lower than those of non-left-behind children (65·7%, 79·9%;P< 0·001). After controlling for potential confounders, we found that the parenting pattern, annual household income and attitude of the primary caregiver towards vaccination significantly influenced the vaccination status of children. Moreover, we noted a relatively high prevalence of delayed vaccination among left-behind children. Hence, we believe that the age-appropriate immunisation coverage rate among left-behind children in rural areas should be further improved by delivering and sustaining primary care services.
Placemaking and Assessing Physical Space in the Academic Law Library
Authors: Peoples Lee F 
Published: March 2017

AbstractThe concept of placemaking has been widely utilized by public and university libraries to create spaces with library users in mind. This article by Lee F. Peoples describes how academic law libraries can employ placemaking concepts to support their parent law school's program of legal education, encourage collaborative learning, and connect students with their school's community, values and traditions. This article explains how academic law libraries can assess placemaking activities and other uses of library space and demonstrate a return on investment made into library spaces. The article concludes with some predictions for the future of assessing library space use.
Conversations with Professor Anthony Terry Hanmer “Tony” Smith: a New Zealander's Journey Through English Academia, and Notions of Criminality in Common Law Jurisdictions
Authors: Dingle Lesley 
Published: March 2017

AbstractProfessor Tony Smith was born in Christchurch, New Zealand in 1947. He completed his LLB and LLM at Canterbury University, interspersed with a short-lived sortie into legal work with the Treasury. It was during these formative years that he acquired the deep interest in criminal law and its social and constitutional ramifications that has underpinned his whole career, and which gained him numerous academic advances, culminating in his chair of Criminal and Public Law at Cambridge University in 1996. He is currently Professor of Law at Victoria University, Wellington. This article is written by Lesley Dingle and is based on her interviews with Professor Smith which have been incorporated into the Eminent Scholars Archive at Cambridge.
TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis
Authors: Wang Yiyun , Xu Jiajia , Zhang Xudong , Wang Chuandong , Huang Yan , Dai Kerong , Zhang Xiaoling 
Published: March 2017

AbstractThe incomplete understanding of aberrant neovascularization, which contributes to osteoarthritis suggests that additional modulators have yet to be identified. Our objective was to identify the role of Leucine-rich-alpha-2-glycoprotein1 (LRG1), a new regulator of pathogenic angiogenesis, in osteoarthritis progression and to develop effective treatment strategies. In this study, immunohistochemistry showed that LRG1 was increased in the subchondral bone and articular cartilage in anterior cruciate ligament transection (ACLT) mice. Further studies were focused on the role of LRG1 in osteoarthritis. Results showed that LRG1 promoted angiogenesis and mesenchymal stem cells (MSC) migration, which contribute to aberrant bone formation in the subchondral bone. Moreover, tumor necrosis factor-α (TNF-α), not interleukin-1β (IL-1β), IL-6 or IL-17, induced the LRG1 expression in human umbilical vein endothelial cells and this effect was inhibited by p38 mitogen-activated protein kinase or NF-κB inhibitor. Notably, inhibition of TNF-α and LRG1 activity by Lenalidomide, an inhibitor of TNF-α production, in ACLT mice attenuated degeneration of osteoarthritis articular cartilage. This study shows that TNF-α is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints. Inhibition of TNF-α and LRG1 by Lenalidomide could be a potential therapeutic approach.
RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis
Authors: Chen Shuai , Jiang Shichao , Zheng Wei , Tu Bing , Liu Shen , Ruan Hongjiang , Fan Cunyi 
Published: March 2017

AbstractPeritendinous tissue fibrosis which leads to poor tendon function is a worldwide clinical problem; however, its mechanism remains unclear. Transcription factor RelA/p65, an important subunit in the NF-κB complex, is known to have a critical role in many fibrotic diseases. Here, we show that RelA/p65 functions as a core fibrogenic regulator in tendon adhesion and that its inhibition exerts an anti-fibrogenic effect on peritendinous adhesion. We detected the upregulation of the NF-κB pathway in human tendon adhesion using a gene chip microarray assay and revealed the overexpression of p65 and extracellular matrix (ECM) proteins Collagen I, Collagen III, and α-smooth muscle actin (α-SMA) in human fibrotic tissues by immunohistochemistry and western blotting. We also found that in a rat model of tendon injury, p65 expression correlated with tendon adhesion, whereas its inhibition by small interfering (si)RNA prevented fibrous tissue formation and inflammatory reaction as evidenced by macroscopic, biomechanical, histological, immunohistochemical, and western blotting analyses. Furthermore, in cultured fibroblasts, p65-siRNA, p65-specific inhibitor, Helenalin and JSH23 suppressed cell proliferation and promoted apoptosis, whereas inhibiting the mRNA and protein expression of ECM components and cyclo-oxygenase-2, an inflammatory factor involved in tendon adhesion. Our findings indicate that p65 has a critical role in peritendinous tissue fibrosis and suggest that p65 knockdown may be a promising therapeutic approach to prevent tendon adhesion.
Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia
Authors: Dong Rui , Yang Yifan , Shen Zhen , Zheng Chao , Jin Zhu , Huang Yanlei , Zhang Zhien , Zheng Shan , Chen Gong 
Published: March 2017

AbstractBiliary atresia is a rare, devastating disease of infants where a fibroinflammatory process destroys the bile ducts, leading to fibrosis and biliary cirrhosis, and death if untreated. The cause and pathogenesis remain largely unknown. We tried to investigate factors involved in biliary atresia, especially forkhead box A3 (Foxa3), which might exert a role in the treatment of liver disease. We used RNA sequencing to sequence the whole transcriptomes of livers from six biliary atresia and six choledochal cysts patients. Then, we employed a rat disease model by bile duct ligation (BDL) and adenovirus transduction to address the function of Foxa3 in biliary atresia. We found that tight junction, adherence junction, cell cycle, apoptosis, chemokine singling, VEGF and MAPK signaling pathways were enriched in biliary atresia livers. We showed that Foxa3 expression was notably decreased in liver samples from biliary atresia patients. More importantly, we found that its lower expression predicted a poorer overall survival of biliary atresia patients. Rats that received BDL surgery and Foxa3 expression adenovirus resulted in a significant decrease in the deposition of collagen, and expression of profibrotic cytokines (transforming growth factor-β and connective tissue growth factor) and fibrosis markers (α-smooth muscle actin, collagen I and collagen III), as compared with rats that received BDL surgery and control adenovirus. Our data suggested a protection role for Foxa3 during the progression of liver fibrosis in biliary atresia, and thereby supported increasing Foxa3 as a targeted treatment strategy.
Temperature-tunable Fano resonance induced by strong coupling between Weyl fermions and phonons in TaAs
Authors: Xu B. , Dai Y. M. , Zhao L. X. , Wang K. , Yang R. , Zhang W. , Liu J. Y. , Xiao H. , Chen G. F. , Trugman S. A. , Zhu J-X , Taylor A. J. , Yarotski D. A. , Prasankumar R. P. , Qiu X. G. 
Published: March 2017

AbstractStrong coupling between discrete phonon and continuous electron–hole pair excitations can induce a pronounced asymmetry in the phonon line shape, known as the Fano resonance. This effect has been observed in various systems. Here we reveal explicit evidence for strong coupling between an infrared-active phonon and electronic transitions near the Weyl points through the observation of a Fano resonance in the Weyl semimetal TaAs. The resulting asymmetry in the phonon line shape, conspicuous at low temperatures, diminishes continuously with increasing temperature. This behaviour originates from the suppression of electronic transitions near the Weyl points due to the decreasing occupation of electronic states below the Fermi level (EF) with increasing temperature, as well as Pauli blocking caused by thermally excited electrons above EF. Our findings not only elucidate the mechanism governing the tunable Fano resonance but also open a route for exploring exotic physical phenomena through phonon properties in Weyl semimetals.
CombiROC: an interactive web tool for selecting accurate marker combinations of omics data
Authors: Mazzara Saveria , Rossi Riccardo L. , Grifantini Renata , Donizetti Simone , Abrignani Sergio , Bombaci Mauro 
Published: March 2017

AbstractDiagnostic accuracy can be improved considerably by combining multiple markers, whose performance in identifying diseased subjects is usually assessed via receiver operating characteristic (ROC) curves. The selection of multimarker signatures is a complicated process that requires integration of data signatures with sophisticated statistical methods. We developed a user-friendly tool, called CombiROC, to help researchers accurately determine optimal markers combinations from diverse omics methods. With CombiROC data from different domains, such as proteomics and transcriptomics, can be analyzed using sensitivity/specificity filters: the number of candidate marker panels rising from combinatorial analysis is easily optimized bypassing limitations imposed by the nature of different experimental approaches. Leaving to the user full control on initial selection stringency, CombiROC computes sensitivity and specificity for all markers combinations, performances of best combinations and ROC curves for automatic comparisons, all visualized in a graphic interface. CombiROC was designed without hard-coded thresholds, allowing a custom fit to each specific data: this dramatically reduces the computational burden and lowers the false negative rates given by fixed thresholds. The application was validated with published data, confirming the marker combination already originally described or even finding new ones. CombiROC is a novel tool for the scientific community freely available at http://CombiROC.eu.