bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of oral triamcinolone to treating proliferative and necrotising otitis externa in a 14-year-old Persian cat
Authors: Momota Yutaka , Yasuda Junya , Arai Nobuaki , Yamamoto Masami , Yoshimura Hisashi , Ikezawa Mitsutaka , Suzuki Shuji , Takahashi Kimimasa , Sako Toshinori 
Published: February 2017

Case summary A 14-year-old female spayed cat was referred for recurrent otitis externa and unusual proliferative lesions in both ear canals. The affected pinnae and external ear canals were covered with large reddish-to-dark-brown verrucous and necrotic tissue. Friable material and exudates occluded both ear canals. Proliferative lesions developed in both ears 2–3 weeks before referral. The histopathological diagnosis from two biopsies obtained from the friable materials with endoscopic biopsy forceps was proliferative and necrotising otitis externa (PNOE). Treatment was initiated with once-daily application of a potent topical glucocorticoid (mometasone furoate) to both ears. Although the auricle and vertical ear canals responded well, no improvement was seen in the horizontal part of the ear canal after 9 weeks. Therefore, oral triamcinolone (0.9 mg/kg q24h) was added for 1 week, and was then tapered (q48h) for 3 weeks. Most lesions resolved, and after a further 2 weeks of prednisolone (2 mg/kg q48h) there was complete resolution. No recurrence was observed during a 2 year follow-up period. Relevance and novel information PNOE commonly occurs in kittens, but it can develop in older cats. To our knowledge, the PNOE in this case is the oldest age of onset reported. This condition is rare and was only described recently, and therapeutic options appear limited. According to previously published reports, steroid therapy is ineffective, and tacrolimus is the only treatment known to achieve resolution. However, oral and topical glucocorticoids were beneficial in this case.
Mapping arsenopyrite alteration in a quartz vein-hosted gold deposit using microbeam analytical techniques
Authors: Gilligan M. , Costanzo A. , Feely M. , Rollinson G. K. , Timmins E. , Henry T. , Morrison L. 
Published: February 2017

AbstractAn unworked quartz vein-hosted gold deposit occurs in the Clew bay area of County Mayo, western Ireland. The veins are late-Caledonian in age and transect greenschist-facies poly-deformed Silurian quartzites. The veins contain disseminated arsenopyrite that may be a primary mineral source for elevated levels of arsenic (As) found in groundwater samples recovered from wells related spatially to the gold deposit. Levels from 5 to 188 μg/L (significantly above the 7.5 μg/L threshold for safe drinking water) have been detected. A series of element distribution maps using a scanning electron microscope (Hitachi model S-4700) linked to an energy-dispersive spectrometer (INCA® Oxford Instruments) and mineral distribution maps generated by QEMSCAN® (Quantitative Evaluation of Minerals by Scanning electron microscopy) were used to map the distribution of the primary arsenopyrite and related secondary As-bearing phases. Laser Raman microspectroscopy was used to identify the secondary As-bearing phases. 'Island weathering' of primary arsenopyrite together with hydrated pseudomorphs of arseniosiderite, pharmacosiderite and scorodite after arsenopyrite are recorded. Circulating groundwater hydrates the primary arsenopyrite, providing the release mechanism that forms the secondary As-bearing phases that occur as microfracture infills together with muscovite and biotite. The textural relationships between the primary and secondary As minerals indicate their potential as mineral sources of As that could enter transport pathways leading to its release into groundwater.
Epidote supergroup nomenclature: The names hancockite, niigataite and tweddillite reinstated
Authors: Revheim Olav , King Vandall T. 
Published: February 2017

AbstractThe epidote-group nomenclature report by Armbruster et al. (2006) provides a clear and concise definition of the epidote group, and a set of consistent rules and naming conventions for establishing new subgroups and mineral species within what is now the epidote supergroup (Mills et al., 2009). In order to comply with these rules, it was decided to rename the already approved minerals hancockite, niigataite and tweddillite to epidote-(Pb), clinozoisite-(Sr) and manganipiemontite-(Sr), respectively. These names were already well established within the mineral community, and the renaming caused some controversy. Recent International Mineralogical Association guidelines (Hatert et al. 2013) have given priority to the historical provenance of names over nomenclature consistency. Hatert et al. (2013) state as a main principle that "retroactivity will not be applied", but that "Every change in nomenclature has to go through the CNMNC, and is examined on its own merit", thus establishing a mechanism for re-instating historical names on a case by case basis. The CNMNC (Commission on New Minerals, Nomenclature and Classification Committee of the International Mineralogical Association) has therefore decided, as an exception to the main principle, to re-instate hancockite, niigataite and tweddillite. In part to maintain the historical names but, more importantly, re-establish the link between the mineral names and their structural and chemical definitions.
Goal-directed fluid restriction during brain surgery: a prospective randomized controlled trial
Authors: Luo Jinfeng , Xue Jing , Liu Jin , Liu Bin , Liu Li , Chen Guo 
Published: February 2017

Abstract
Background
The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown. The aim of our study was to evaluate the effect of an intraoperative goal-directed fluid restriction (GDFR) strategy on the postoperative outcome of high-risk patients undergoing brain surgery.

Methods
High-risk patients undergoing brain surgery were randomly assigned to a usual care group (control group) or a GDFR group. In the GDFR group, (1) fluid maintenance was restricted to 3 ml/kg/h of a crystalloid solution and (2) colloid boluses were allowed only in case of hypotension associated with a low cardiac index and a high stroke volume variation. The primary outcome variable was ICU length of stay, and secondary outcomes were lactates at the end of surgery, postoperative complications, hospital length of stay, mortality at day 30, and costs.

Results
A total of 73 patients from the GDFR group were compared with 72 patients from the control group. Before surgery, the two groups were comparable. During surgery, the GDFR group received less colloid (1.9 ± 1.1 vs. 3.9 ± 1.6 ml/kg/h, p = 0.021) and less crystalloid (3 ± 0 vs. 5.0 ± 2.8 ml/kg/h, p < 0.001) than the control group. ICU length of stay was shorter (3 days [1–5] vs. 6 days [3–11], p = 0.001) and ICU costs were lower in the GDFR group. The total number of complications (46 vs. 99, p = 0.043) and the proportion of patients who developed one or more complications (19.2 vs. 34.7%, p = 0.034) were smaller in the GDFR group. Hospital length of stay and costs, as well as mortality at 30 day, were not significantly reduced.

Conclusion
In high-risk patients undergoing brain surgery, intraoperative GDFR was associated with a reduction in ICU length of stay and costs, and a decrease in postoperative morbidity.
Trial registration Chinese Clinical Trial Registry ChiCTR-TRC-13003583, Registered 20 Aug, 2013
The effectiveness of spawning habitat creation or enhancement for substrate spawning temperate fish: a systematic review protocol
Authors: Taylor Jessica J. , Rytwinski Trina , Bennett Joseph R. , Smokorowski Karen E. , Cooke Steven J. 
Published: February 2017

Abstract
Background
Habitat is the foundation for healthy and productive fisheries. For substrate spawning fish, lack of appropriate spawning substrate is inherently limiting and a lack of access to suitable spawning habitat will lead to population collapse. When specific properties of a habitat (e.g., temperature, depth, vegetation composition) are matched to the species’ ecological niche, a spawning habitat can be created or enhanced as a means of mitigating or offsetting the harmful effects of human development. Given the acceleration of habitat degradation in aquatic systems as a result of human activity and resultant loss of biodiversity, it is becoming ever more important to consider the effectiveness of the techniques being used to enhance or create habitat, to ensure management resources are being allocated wisely. The primary aim of this systematic review will be to assess the effectiveness of techniques currently being used to create or enhance spawning habitat for substrate spawning fish in temperate climate regions.

Methods
This review will examine studies on the effectiveness of habitat creation or enhancement for substrate spawning fish. We will consider studies in either the North or South temperate climate regions, and include freshwater, estuarine, coastal, or marine environments. Relevant outcomes will include a range of measures used by authors to define effectiveness, including but not limited to the presence of eggs, successful emergence, or improved recruitment. This review will obtain relevant studies from online publication databases, specialist websites, and grey literature using a range of search engines and networking tools. Additional searches will be conducted using the bibliographies of relevant review publications. Study data will be extracted and appraised for quality, including study design, confounding factors, and statistical analysis. A narrative synthesis will be compiled and a meta-analysis will be completed should the data availability and quality allow for it.
Applying shot boundary detection for automated crystal growth analysis during in situ transmission electron microscope experiments
Authors: Moeglein W. A. , Griswold R. , Mehdi B. L. , Browning N. D. , Teuton J. 
Published: February 2017

AbstractIn situ scanning transmission electron microscopy is being developed for numerous applications in the study of nucleation and growth under electrochemical driving forces. For this type of experiment, one of the key parameters is to identify when nucleation initiates. Typically, the process of identifying the moment that crystals begin to form is a manual process requiring the user to perform an observation and respond accordingly (adjust focus, magnification, translate the stage, etc.). However, as the speed of the cameras being used to perform these observations increases, the ability of a user to “catch” the important initial stage of nucleation decreases (there is more information that is available in the first few milliseconds of the process). Here, we show that video shot boundary detection can automatically detect frames where a change in the image occurs. We show that this method can be applied to quickly and accurately identify points of change during crystal growth. This technique allows for automated segmentation of a digital stream for further analysis and the assignment of arbitrary time stamps for the initiation of processes that are independent of the user’s ability to observe and react.
Data systems for the Linac coherent light source
Authors: Thayer J. , Damiani D. , Ford C. , Dubrovin M. , Gaponenko I. , O’Grady C. P. , Kroeger W. , Pines J. , Lane T. J. , Salnikov A. , Schneider D. , Tookey T. , Weaver M. , Yoon C. H. , Perazzo A. 
Published: February 2017

AbstractThe data systems for X-ray free-electron laser (FEL) experiments at the Linac coherent light source (LCLS) are described. These systems are designed to acquire and to reliably transport shot-by-shot data at a peak throughput of 5 GB/s to the offline data storage where experimental data and the relevant metadata are archived and made available for user analysis. The analysis and monitoring implementation (AMI) and Photon Science ANAlysis (psana) software packages are described. Psana is open source and freely available.
Efficient implementation of a local tomography reconstruction algorithm
Authors: Paleo Pierre , Mirone Alessandro 
Published: February 2017

AbstractWe propose an efficient implementation of an interior tomography reconstruction method based on a known subregion. This method iteratively refines a reconstruction, aiming at reducing the local tomography artifacts. To cope with the ever increasing data volumes, this method is highly optimized on two aspects: firstly, the problem is reformulated to reduce the number of variables, and secondly, the operators involved in the optimization algorithms are efficiently implemented. Results show that $$4096^2$$

4096
2

slices can be processed in tens of seconds, while being beyond the reach of equivalent exact local tomography method.
Nanosurveyor: a framework for real-time data processing
Authors: Daurer Benedikt J. , Krishnan Hari , Perciano Talita , Maia Filipe R. N. C. , Shapiro David A. , Sethian James A. , Marchesini Stefano 
Published: February 2017

Abstract
Background
The ever improving brightness of accelerator based sources is enabling novel observations and discoveries with faster frame rates, larger fields of view, higher resolution, and higher dimensionality.

Results
Here we present an integrated software/algorithmic framework designed to capitalize on high-throughput experiments through efficient kernels, load-balanced workflows, which are scalable in design. We describe the streamlined processing pipeline of ptychography data analysis.

Conclusions
The pipeline provides throughput, compression, and resolution as well as rapid feedback to the microscope operators.
Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy
Authors: Norris Rachael P. , Baena Valentina , Terasaki Mark 
Published: February 2017

ABSTRACT
Gap junction turnover occurs through the internalization of both of the plasma membranes of a gap junction plaque, forming a double membrane-enclosed vesicle, or connexosome. Phosphorylation has a key role in regulation, but further progress requires the ability to clearly distinguish gap junctions and connexosomes, and to precisely identify proteins associated with them. We examined, by using electron microscopy, serial sections of mouse preovulatory ovarian follicles that had been collected with an automated tape collecting ultramicrotome (ATUM). We found that connexosomes can form from adjacent cell bodies, from thin cell processes or from the same cell. By immunolabeling serial sections, we found that residue S368 of connexin 43 (also known as GJA1) is phosphorylated on gap junctions and connexosomes, whereas connexin 43 residue S262 is phosphorylated only on some connexosomes. These data suggest that phosphorylation at S262 contributes to connexosome formation or processing, and they provide more precise evidence that phosphorylation has a key role in gap junction internalization. Serial section electron microscopy of immunogold-labeled tissues offers a new way to investigate the three-dimensional organization of cells in their native environment.
Time Matters Less When Outcomes Differ: Unimodal vs. Cross-Modal Comparisons in Intertemporal Choice
Authors: Cubitt Robin , McDonald Rebecca , Read Daniel 
Published: February 2017

Unimodal intertemporal decisions involve comparing options of the same type (e.g., apples now versus apples later), and cross-modal decisions involve comparing options of different types (e.g., a car now versus a vacation later). As we show, existing models of intertemporal choice do not allow time preference to depend on whether the comparisons to be made are unimodal or cross-modal. We test this restriction in an experiment using the delayed compensation method, a new extension of the standard method of eliciting intertemporal preferences that allows for assessment of time preference for nonmonetary and discrete outcomes, as well as for both cross-modal and unimodal comparisons. Participants were much more averse to delay for unimodal than cross-modal decisions. We provide two potential explanations for this effect: one drawing on multiattribute choice, the other drawing on construal-level theory. Data are available at https://doi.org/10.1287/mnsc.2016.2613 . This paper was accepted by Yuval Rottenstreich, judgment and decision making.
Unfair Pay and Health
Authors: Falk Armin , Kosse Fabian , Menrath Ingo , Verde Pablo E. , Siegrist Johannes 
Published: February 2017

This paper investigates physiological responses to perceptions of unfair pay. We use an integrated approach that exploits complementarities between controlled laboratory and representative panel data. In a simple principal–agent experiment, agents produce revenue by working on a tedious task. Principals decide how this revenue is allocated between themselves and their agents. Throughout the experiment we record agents’ heart rate variability, which is an indicator of stress-related impaired cardiac autonomic control and which has been shown to predict coronary heart disease in the long run. Our findings establish a link between unfair payment and heart rate variability. Building on these findings, we further test for potential adverse health effects of unfair pay using observational data from a large representative panel data set. Complementary to our experimental findings we show a strong and significant negative association between unfair pay and health outcomes, in particular cardiovascular health.Data are available at https://doi.org/10.1287/mnsc.2016.2630 .This paper was accepted by Uri Gneezy, behavioral economics.
If You’re Going to Do Wrong, At Least Do It Right: Considering Two Moral Dilemmas at the Same Time Promotes Moral Consistency
Authors: Barak-Corren Netta , Tsay Chia-Jung , Cushman Fiery , Bazerman Max H. 
Published: February 2017

We study how people reconcile conflicting moral intuitions by juxtaposing two versions of classic moral problems: the trolley problem and the footbridge problem. When viewed separately, most people favor action in the former and disapprove of action in the latter, despite identical consequences. The difference is often explained in terms of the intention principle—whether the consequences are intended or incidental. Our results suggest that when the two problems are considered together, a different judgment emerges: participants reject the intention principle and embrace either the principle of utilitarianism, which favors action in both problems, or the action principle, which rejects action in both problems. In subsequent studies, we find that when required to choose between two harmful actions, people prefer the action that saves more lives, despite its being more aversive. Our findings shed light on the formation of moral judgment under normative conflict, the conditions for preference reversal, and the potential polarization of moral judgment under joint evaluation. Organizational implications are discussed. Data are available at https://doi.org/10.1287/mnsc.2016.2659 . This paper was accepted by Yuval Rottenstreich, judgment and decision making.
Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry
Authors: Pacifici Roberta , Marchei Emilia , Salvatore Francesco , Guandalini Luca , Busardò Francesco Paolo , Pichini Simona 
Published: February 2017

AbstractBackground:Cannabis has been used since ancient times to relieve neuropathic pain, to lower intraocular pressure, to increase appetite and finally to decrease nausea and vomiting. The combination of the psychoactive cannabis alkaloid Δ9-tetrahydrocannabinol (THC) with the non-psychotropic alkaloids cannabidiol (CBD) and cannabinol (CBN) demonstrated a higher activity than THC alone. The Italian National Institute of Health sought to establish conditions and indications on how to correctly use nationally produced cannabis to guarantee therapeutic continuity in individuals treated with medical cannabis.Methods:The evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil was conducted using an easy and fast ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) assay.Results:Extraction efficiency of oil was significantly higher than that of water with respect to the different cannabinoids. This was especially observed in the case of the pharmacologically active THC, CBD and their acidic precursors. Fifteen minutes boiling was sufficient to achieve the highest concentrations of cannabinoids in the cannabis tea solutions. At ambient temperature, a significant THC and CBD decrease to 50% or less of the initial concentration was observed over 3 and 7 days, respectively. When refrigerated at 4 °C, similar decreasing profiles were observed for the two compounds. The cannabinoids profile in cannabis oil obtained after pre-heating the flowering tops at 145 °C for 30 min in a static oven resulted in a complete decarboxylation of cannabinoid acids CBDA and THCA-A. Nevertheless, it was apparent that heat not only decarboxylated acidic compounds, but also significantly increased the final concentrations of cannabinoids in oil. The stability of cannabinoids in oil samples was higher than that in tea samples since the maximum decrease (72% of initial concentration) was observed in THC coming from unheated flowering tops at ambient temperature. In the case of the other cannabinoids, at ambient and refrigerated temperatures, 80%–85% of the initial concentrations were measured up to 14 days after oil preparation.Conclusions:As the first and most important aim of the different cannabis preparations is to guarantee therapeutic continuity in treated individuals, a strictly standardized preparation protocol is necessary to assure the availability of a homogeneous product of defined stability.
Reporting altered test results in hemolyzed samples: is the cure worse than the disease?
Authors: Lippi Giuseppe , Cervellin Gianfranco , Plebani Mario 
Published: February 2017

AbstractThe management of laboratory data in unsuitable (hemolyzed) samples remains an almost unresolved dilemma. Whether or not laboratory test results obtained by measuring unsuitable specimens should be made available to the clinicians has been the matter of fierce debates over the past decades. Recently, an intriguing alternative to suppressing test results and recollecting the specimen has been put forward, entailing the definition and implementation of specific algorithms that would finally allow reporting a preanalytically altered laboratory value within a specific comment about its uncertainty of measurement. This approach carries some advantages, namely the timely communication of potentially life-threatening laboratory values, but also some drawbacks. These especially include the challenging definition of validated performance specifications for hemolyzed samples, the need to producing reliable data with the lowest possible uncertainty, the short turnaround time for repeating most laboratory tests, the risk that the comments may be overlooked in short-stay and frequently overcrowded units (e.g. the emergency department), as well as the many clinical advantages of a direct communication with the physician in charge of the patient. Despite the debate remains open, we continue supporting the suggestion that suppressing data in unsuitable (hemolyzed) samples and promptly notifying the clinicians about the need to recollect the samples remains the most (clinically and analytically) safe practice.