bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kautsky’s Unexpected Comeback: Understanding the Re-emergence of the Second International in Contemporary Debates
Authors: Poy Lucas 
Published: September 2024

AbstractIn the history of the left, the conjuncture 1914–1917 is the “bifurcation point” per definition. Leaving an enduring mark on the labor movement, it also shaped subsequent historiographies. For the pro-Bolshevik left, 1914 epitomized the betrayal of a group of reformist leaders. Conversely, anti-communist social democrats regarded the Second International as an uncomfortable political heritage. Despite irreconcilable disputes, both traditions shared a lack of interest in defending the period 1889–1914, let alone delving into its history. The real take-off of Second International historiography came later and coincided with the outset of the Cold War, experiencing a “golden age” in the 1960s and 1970s. Studies of socialism lost momentum from the 1980s onwards, but the last 15 years have seen a resurgence of interest in the Second International and even a popular reappraisal of Karl Kautsky. Linking historiography to wider social and political phenomena, this article reflects on this new interest in the Second International in both activist and academic circles. The first section summarizes the historical significance of the International and examines how the crisis of 1914 became a crucial “bifurcation point” with significant political and historiographical impact. The second section explores recent trends in scholarly research on the subject. The third section provides an analysis of the vindication of Karl Kautsky among radicals and socialists in the United States over the past 10 years. The conclusion summarizes the main arguments and reflects on the contribution this analysis can make to a discussion about the “long cycle” of socialism.
Industrial policy and the green state: Forging a world after growth
Authors: Allan Bentley B. 
Published: September 2024

AbstractThe resurgence of industrial policy is reshaping the global political economy and creating emergent formations that could help create green states. Such green states can seed a world after growth. Growth is often taken for granted as a natural purpose of states and an appropriate basis of public policy. However, it has a recent political-economic and cosmological history. This suggests that an age after growth is not only possible but likely. In the current conjuncture of crises and challenges, industrial strategies that bring together environmental, social justice, and pro-growth coalitions offer the best chance to meet climate goals and improve the prospects for inclusive prosperity globally. In addition, there is evidence that industrial policy is providing a platform to build active states, rebalance state–business relations, forge new systems of calculation, and gather cosmological resources for new action.
An application of natural matrices to the dynamic balance problem of planar parallel manipulators
Authors: Gallardo-Alvarado Jaime 
Published: September 2024

AbstractThis paper introduces a simplified matrix method for balancing forces and moments in planar parallel manipulators. The method resorts to Newton’s second law and the concept of angular momentum vector, yet it is not necessary to perform the velocity and acceleration analyses, tasks that were normally unavoidable in seminal contributions. With the introduction of natural matrices, the proposed balancing method is independent of the time and the trajectory generated by the moving links of parallel manipulators. The effectiveness of the method is exemplified by balancing two planar parallel manipulators.
Control of stance-leg motion and zero-moment point for achieving perfect upright stationary state of rimless wheel type walker with parallel linkage legs
Authors: Asano Fumihiko , Kawai Mizuki 
Published: September 2024

AbstractThe authors have studied models and control methods for legged robots without having active ankle joints that can not only walk efficiently but also stop and developed a method for generating a gait that starts from an upright stationary state and returns to the same state in one step for a simple walker with one control input. It was clarified, however, that achieving a perfect upright stationary state including zero dynamics is impossible. Based on the observation, in this paper we propose a novel robotic walker with parallel linkage legs that can return to a perfect stationary standing posture in one step while simultaneously controlling the stance-leg motion and zero-moment point (ZMP) using two control inputs. First, we introduce a model of a planar walker that consists of two eight-legged rimless wheels, a body frame, a reaction wheel, and massless rods and describe the system dynamics. Second, we consider two target control conditions; one is control of the stance-leg motion, and the other is control of the ZMP to stabilize zero dynamics. We then determine the control input based on the two conditions with the target control period derived from the linearized model and consider adding a sinusoidal control input with an offset to correct the resultant terminal state of the reaction wheel. The validity of the proposed method is investigated through numerical simulations.
Cumulative risk and adolescent emotional distress: A longitudinal moderated mediation analysis focusing on perceived stress and social support
Authors: Deniz Emre , Humphrey Neil , Demkowicz Ola , Lereya Suzet Tanya , Deighton Jessica 
Published: September 2024

Abstract
This study provides insights into the roles played by perceived stress and social support in the relationship between cumulative risk exposure (CRE) and adolescent emotional distress. Preregistered longitudinal moderated mediation analyses were used to test hypotheses relating to the association between CRE and later emotional distress; the mediating role of perceived stress in the relationship between CRE and later emotional distress; and, the moderating effects of peer and adult-level family support on the relationship between CRE and later perceived stress, among N = 19,159 adolescents over three annual waves (at ages 11/12, 12/13, 13/14). Analyses revealed that CRE significantly predicted later adolescent emotional distress. This relationship was partially mediated by perceived stress. Both peer and adult-level family support significantly moderated the impact of CRE on later perceived stress (i.e., adolescents reporting higher levels of support perceived significantly lower levels of stress resulting from CRE compared to those reporting lower levels of support). These findings provide critical empirical evidence of the roles played by perceived stress and social support in the relationship between CRE and adolescent emotional distress, with consequent implications for intervention.
Comparing and linking the Mini-Mental State Examination and Montreal Cognitive Assessment in the Amsterdam Dementia Cohort
Authors: Dubbelman Mark A. , van de Beek Marleen , van Gils Aniek M. , Leeuwis Anna E. , van der Vlies Annelies E. , Pijnenburg Yolande A.L. , Ponds Rudolf , Sikkes Sietske A.M. , van der Flier Wiesje M. 
Published: September 2024

AbstractObjectives:We aimed to compare and link the total scores of the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), two common global cognitive screeners.Methods:2,325 memory clinic patients (63.2 ± 8.6 years; 43% female) with a variety of diagnoses, including subjective cognitive decline, mild cognitive impairment, and dementia due to various etiologies completed the MMSE and MoCA concurrently. We described both screeners, including at the item level. Then, using linear regressions, we investigated how age, sex, education, and diagnosis affected total scores on both instruments. Next, in linear mixed models, we treated the two screeners as repeated measures and analyzed the influence of these characteristics on the relationship between the instruments’ total scores. Finally, we linked total scores using equipercentile equating, accounting for relevant patient characteristics.Results:MMSE scores (mean ± standard deviation: 25.0 ± 4.6) were higher than MoCA scores (21.2 ± 5.4), and MMSE items generally showed less variation than MoCA items. Both instruments’ scores were individually influenced by age, sex, education, and diagnosis. The relationship between the screeners was moderated by age (estimate = −0.01, 95% confidence interval = [−0.03, −0.00]), education (0.14 [0.10, 0.18]), and diagnosis. These were accounted for when producing crosswalk tables based on equipercentile equating.Conclusions:Accounting for the influence of patient characteristics, we created crosswalk tables to convert MMSE scores to MoCA scores, and vice versa. These tables may facilitate collaboration between clinicians and researchers and could allow larger, pooled analyses of global cognitive functioning in older adults.
The Malacca dilemma of the Raj: the Indian Uprising of 1857, the Second Opium War, and the British proposal of a Kra passage
Authors: Cao Yin 
Published: September 2024

AbstractIn the late 1850s and early 1860s, the idea of building a passage through the Isthmus of Kra in the Malay Peninsula was hotly debated amongst British officials, merchants, and investors. This study finds that the British East India Company's rule over the Straits of Malacca had been a dilemma for itself and British merchants in China. The Second Opium War and the Indian Revolt of 1857 exacerbated the dilemma and pushed some British policymakers and investors to seek an alternative route between India and China. The proposal of the Kra passage was the response and solution to the Malacca dilemma. In historicising the Kra passage proposal and putting it in the context of the British empire's simultaneous crises in Asia in the mid-nineteenth century, the case of the proposed Kra passage reveals the complex relations between different actors within the British empire and the challenges of integrating multiple imperial interests into a British world system
Social security and retirement around the world: lessons from a long-term collaboration
Authors: Coile Courtney , Wise David , Börsch-Supan Axel , Gruber Jonathan , Milligan Kevin , Woodbury Richard , Baker Michael , Banks James , Behaghel Luc , Ben Salem Melika , Bingley Paul , Blanchet Didier , Blundell Richard , Boldrín Michele , Bozio Antoine , Brugiavini Agar , Bucher-Koenen Tabea , Buia Raluca Elena , Caroli Eve , Debrand Thierry , Dellis Arnaud , Desmet Raphaël , de Vos Klaas , Diamond Peter , Emmerson Carl , Ferrari Irene , Fraikin Anne-Lore , Fujii Mayu , García-Gómez Pilar , Garcia-Mandicó Sílvia , Goll Nicolas , Gupta Nabanita Datta , Jiménez-Martín Sergi , Johansson Per , Johnson Paul , Jørgensen Michael , Jousten Alain , Jürges Hendrik , Kallestrup-Lamb Malene , Kalwij Adriaan , Kapteyn Arie , Kohnz Simone , Laun Lisa , Lefebvre Mathieu , Mahieu Ronan , Mastrobuoni Giovanni , Meghir Costas , Oishi Akiko , Oshio Takashi , Palme Mårten , Pasini Giacomo , Pedersen Peder , Pelé Louis-Paul , Peracchi Franco , Perelman Sergio , Pestieau Pierre , Prost Corinne , Rabaté Simon , Rausch Johannes , Roger Muriel , Schirle Tammy , Schnabel Reinhold , Schuth Morten , Shimizutani Satoshi , Smith Sarah , Stijns Jean-Philippe , Sturrock David , Svensson Ingemar , Tetlow Gemma , Thiel Lars , Tô Maxime , Tréguier Julie , Usui Emiko , Vall-Castelló Judit , Walraet Emmanuelle , Weber Guglielmo , Yashiro Naohiro 
Published: September 2024

AbstractDeclining labor force participation of older men throughout the 20th century and recent increases in participation have generated substantial interest in understanding the effect of public pensions on retirement. The National Bureau of Economic Research's International Social Security (ISS) Project, a long-term collaboration among researchers in a dozen developed countries, has explored this and related questions. The project employs a harmonized approach to conduct within-country analyses that are combined for meaningful cross-country comparisons. The key lesson is that the choices of policy makers affect the incentive to work at older ages and these incentives have important effects on retirement behavior.
Value, Price, and Economic Reform in the Polish People's Republic
Authors: Porter-Szűcs Brian 
Published: September 2024

AbstractMarxists have long argued about the viability of “market socialism.” That model was dominant among professional economists in the Polish People’s Republic after the fall of Stalinism in 1956, even though they were never able to fully implement its principles. This article explores the debates over this concept in communist Poland, identifying the central issue as an attempt to combine socialist goals with neoclassical methodological principles and theoretical assumptions, particularly regarding price formation. Advocates of central planning always claimed that this mixture was unsustainable, destined to slide towards a restoration of capitalism. They were probably right.
Martian Impact Fracturing Pervasively Influences Habitability
Authors: Cockell C. S. , Collins G. S. , Basu S. , Grant E. , McMahon S. 
Published: September 2024

AbstractOn Mars, the lack of either plate tectonics or a prominent erosional hydrological cycle since the Noachian means geological changes caused by asteroid and comet impact events have been preserved. On Earth, surviving impact‐induced fractures are localized to the relatively few preserved craters on the planet. We estimate that the shell of impact‐fractured rock on Mars (the “impact‐sphere”) could provide between 9,200 times the surface area of a Mars radius sphere and up to 100 times this value, depending on the assumptions made, as potential microbially accessible space. Although >93% of craters we consider are smaller than 10 km in diameter, they contribute only about 5% of the total fracture surface area generated by all craters, making complex craters the dominant process for potential habitat formation. Microbiological data from terrestrial impact craters suggest that these fractures could have significantly enhanced local habitability by providing pathways for fluid flow, and thus nutrients and energy. However, unlike on Earth, the geological history of Mars means that pervasive impact fractures may also have provided pathways for Hesperian and Amazonian brines to infiltrate the subsurface and locally reduce habitability. Combining the fracture data with previous microbiological observations provides testable hypotheses for Martian drilling missions.
High‐Pressure Melting Experiments of Fe3C and a Thermodynamic Model of Fe‐C Liquids for the Earth's Core
Authors: Komabayashi T. , McGuire C. , Thompson S. , Bromiley G. D. , Bravenec A. , Pakhomova A. 
Published: September 2024

AbstractMelting experiments of Fe3C were conducted to 85 GPa in laser‐heated diamond anvil cells with in situ X‐ray diffraction and post‐experiment textural observation. From the determined pressure‐temperature conditions of the melting curve for Fe3C, together with literature data on the melting point of diamond and eutectic point of the system Fe‐Fe3C/Fe7C3 under high pressures, we established a self‐consistent thermodynamic model for high‐pressure melting of the system Fe‐C including the mixing parameters for liquids. The results show that mixing of Fe and C liquids is negatively nonideal from 1 bar to the pressure at the center of the Earth. The departure from ideal mixing becomes progressively larger with increasing pressure, which leads to greatly stabilized liquids under core pressures. The modeled carbon content in eutectic melts under core pressures is 3.3–4.4 wt%. From the Gibbs free energy, we derived an internally consistent parameters for Fe‐C outer cores which included the crystallizing points at their bottoms, isentropic thermal profiles, and densities and longitudinal seismic wave speeds (Vp). While the addition of carbon in excess of the eutectic melt composition effectively reduces the density of iron liquid, the Vp of iron liquid is not greatly changed. Therefore, the low density and high Vp of PREM relative to pure iron cannot be reconciled by an Fe‐C liquid. Therefore, the Earth's core cannot be approximated by the system Fe‐C and should include another light element.
Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins
Authors: Halilovic Melisa , Abdelsalam Mohamed , Zabkiewicz Joanna , Lazenby Michelle , Alvares Caroline , Schmidt Matthias , Brenner Walburgis , Najafi Sara , Oehme Ina , Hieber Christoph , Zeyn Yanira , Bros Matthias , Sippl Wolfgang , Krämer Oliver H. 
Published: September 2024

AbstractInternal tandem duplications in the FMS-like tyrosine kinase-3 (FLT3-ITD) are common mutations in acute myeloid leukemia (AML). Proteolysis-targeting chimeras (PROTACs) that induce proteasomal degradation of mutated FLT3 emerge as innovative pharmacological approach. Molecular mechanisms that control targeted proteolysis beyond the ubiquitin-proteasome-system are undefined and PROTACs are the only known type of FLT3 degraders. We report that the von-Hippel-Lindau ubiquitin-ligase based FLT3 PROTAC MA49 (melotinib-49) and the FLT3 hydrophobic tagging molecule MA50 (halotinib-50) reduce endoplasmic reticulum-associated, oncogenic FLT3-ITD but spare FLT3. Nanomolar doses of MA49 and MA50 induce apoptosis of human leukemic cell lines and primary AML blasts with FLT3-ITD (p < 0.05-0.0001), but not of primary hematopoietic stem cells and differentiated immune cells, FLT3 wild-type cells, retinal cells, and c-KIT-dependent cells. In vivo activity of MA49 against FLT3-ITD-positive leukemia cells is verified in a Danio rerio model. The degrader-induced loss of FLT3-ITD involves the pro-apoptotic BH3-only protein BIM and a previously unidentified degrader-induced depletion of protein-folding chaperones. The expression levels of HSP90 and HSP110 correlate with reduced AML patient survival (p < 0.1) and HSP90, HSP110, and BIM are linked to the expression of FLT3 in primary AML cells (p < 0.01). HSP90 suppresses degrader-induced FLT3-ITD elimination and thereby establishes a mechanistically defined feed-back circuit.
Neural stimulation and modulation with sub-cellular precision by optomechanical bio-dart
Authors: Zhu Guoshuai , Xiong Jianyun , Li Xing , He Ziyi , Zhong Shuhan , Chen Junlin , Shi Yang , Pan Ting , Zhang Li , Li Baojun , Xin Hongbao 
Published: September 2024

AbstractNeural stimulation and modulation at high spatial resolution are crucial for mediating neuronal signaling and plasticity, aiding in a better understanding of neuronal dysfunction and neurodegenerative diseases. However, developing a biocompatible and precisely controllable technique for accurate and effective stimulation and modulation of neurons at the subcellular level is highly challenging. Here, we report an optomechanical method for neural stimulation and modulation with subcellular precision using optically controlled bio-darts. The bio-dart is obtained from the tip of sunflower pollen grain and can generate transient pressure on the cell membrane with submicrometer spatial resolution when propelled by optical scattering force controlled with an optical fiber probe, which results in precision neural stimulation via precisely activation of membrane mechanosensitive ion channel. Importantly, controllable modulation of a single neuronal cell, even down to subcellular neuronal structures such as dendrites, axons, and soma, can be achieved. This bio-dart can also serve as a drug delivery tool for multifunctional neural stimulation and modulation. Remarkably, our optomechanical bio-darts can also be used for in vivo neural stimulation in larval zebrafish. This strategy provides a novel approach for neural stimulation and modulation with sub-cellular precision, paving the way for high-precision neuronal plasticity and neuromodulation.
Role of dorsal striatum circuits in relapse to opioid seeking after voluntary abstinence
Authors: Ma Zilu , Duan Ying , Fredriksson Ida , Tsai Pei-Jung , Batista Ashley , Lu Hanbing , Shaham Yavin , Yang Yihong 
Published: September 2024

Abstract
High relapse rate during abstinence is a defining characteristic of drug addiction. We previously found that opioid seeking progressively increases after voluntary abstinence induced by adverse consequences of oxycodone seeking (crossing an electric barrier). Functional MRI revealed that this effect is associated with changes in functional connectivity within medial orbitofrontal cortex (mOFC)- and dorsomedial striatum (DMS)-related circuits. Here, we used a pharmacological manipulation and fMRI to determine the causal role of mOFC and DMS in oxycodone seeking after electric barrier-induced abstinence. We trained rats to self-administer oxycodone (6 h/day, 14 days). Next, we induced voluntary abstinence by exposing them to an electric barrier for 2 weeks. We inactivated the mOFC and DMS with muscimol+baclofen (GABAa and GABAb receptor agonists) and then tested them for relapse to oxycodone seeking on abstinence days 1 or 15 without the electric barrier or oxycodone. Inactivation of DMS (p < 0.001) but not mOFC decreased oxycodone seeking before or after electric barrier-induced abstinence. Functional MRI data revealed that DMS inactivation decreased cerebral blood volume levels in DMS and several distant cortical and subcortical regions (corrected p < 0.05). Furthermore, functional connectivity of DMS with several frontal, sensorimotor, and auditory regions significantly increased after DMS inactivation (corrected p < 0.05). Finally, an exploratory analysis of an existing functional MRI dataset showed that DMS inactivation restored voluntary abstinence-induced longitudinal changes in DMS functional connectivity with these brain regions (p < 0.05). Results indicate a role of DMS and related brain circuits in oxycodone seeking after voluntary abstinence, suggesting potential targets for intervention.
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
Authors: Zheng Zhikai , Zong Yao , Ma Yiyang , Tian Yucheng , Pang Yidan , Zhang Changqing , Gao Junjie 
Published: September 2024

AbstractThe glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types within the human body. This receptor specifically interacts with GLP-1, a key hormone that plays an integral role in regulating blood glucose levels, lipid metabolism, and several other crucial biological functions. In recent years, GLP-1 medications have become a focal point in the medical community due to their innovative treatment mechanisms, significant therapeutic efficacy, and broad development prospects. This article thoroughly traces the developmental milestones of GLP-1 drugs, from their initial discovery to their clinical application, detailing the evolution of diverse GLP-1 medications along with their distinct pharmacological properties. Additionally, this paper explores the potential applications of GLP-1 receptor agonists (GLP-1RAs) in fields such as neuroprotection, anti-infection measures, the reduction of various types of inflammation, and the enhancement of cardiovascular function. It provides an in-depth assessment of the effectiveness of GLP-1RAs across multiple body systems-including the nervous, cardiovascular, musculoskeletal, and digestive systems. This includes integrating the latest clinical trial data and delving into potential signaling pathways and pharmacological mechanisms. The primary goal of this article is to emphasize the extensive benefits of using GLP-1RAs in treating a broad spectrum of diseases, such as obesity, cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), neurodegenerative diseases, musculoskeletal inflammation, and various forms of cancer. The ongoing development of new indications for GLP-1 drugs offers promising prospects for further expanding therapeutic interventions, showcasing their significant potential in the medical field.