bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transarterial and Transhepatic Endovascular Intervention to Alleviate Portal Hypertension Secondary to Arterioportal Fistula in a Trisomy 21 Infant
Authors: Cil Barbaros , Bayrakci Benan , Sasmaz Necati , Baysoy Gokhan , Gurakan Figen , Yazici Mutlu 
Published: June 2017

AbstractIndividuals with trisomy 21 have an 80% risk reduction of vascular anomalies compared with general population. However, an association of trisomy 21 and portal vascular and arteriovenous anomalies has been defined in the literature. The primary hemodynamic abnormality in portal hypertension is increased resistance to portal blood flow. In various case reports in adults and pediatric age group patients, transarterial coil embolization of hepatoportal fistula was described. One of the authors of this article has previously reported successful treatment of congenital arterioportal fistula (APF) with percutaneous transhepatic liquid embolization in a patient who previously had transarterial coil embolization. To date, eight patients with trisomy 21 (Down syndrome) and congenital portosystemic shunts were reported of which four were treated with embolization. Here, we describe a 3-month-old infant with trisomy 21 and intrahepatic APF associated with extrahepatic portal hypertension and massive ascites. In the current report, a rare case of a patient with a diagnosis of trisomy 21 is discussed who was attempted to be treated with transarterial coil embolization and percutaneous transhepatic liquid embolization of the congenital APF in a single session.
Comparison of Azithromycin versus Erythromycin for Prolongation of Latency in Pregnancies Complicated by Preterm Premature Rupture of Membranes
Authors: Appiagyei Ashley , Templin Megan , Mertz Heather , Finneran Matthew 
Published: June 2017

Objective To assess the impact on the duration of latency to delivery when a single oral dose of azithromycin is substituted for erythromycin in the standard antibiotic regimen used in pregnancies complicated by preterm premature rupture of membranes (PPROM).
Study Design A retrospective cohort study of singleton pregnancies complicated by PPROM between 23 and 33 6/7 weeks of gestation from January 2012 to June 2016. Patients prior to June 2014 received a standard antibiotic regimen of 7 days of erythromycin and ampicillin/amoxicillin. After this period, patients received a single oral dose of azithromycin 1 g substituted for erythromycin in this regimen. Primary outcome was latency from PPROM to delivery.
Results One hundred sixty-two women met the inclusion criteria, 84 in the erythromycin group and 78 in the azithromycin group. There was no difference in the median latency from PPROM to delivery between the groups (erythromycin: 6.37 days, interquartile range [IQR]: 3.59–10.93 vs. azithromycin: 5.86 days, IQR: 3.12–12.05, p = 0.75). There was a higher rate of cesarean delivery (48.8 vs. 29.5%, p = 0.01) and positive neonatal blood cultures (13.6 vs. 4.1%, p = 0.05) in the erythromycin group.
Conclusion There is no difference in latency to delivery when a single oral dose of azithromycin 1 g is substituted for erythromycin in the standard antibiotic regimen used in singleton pregnancies complicated by PPROM.
Vitamine und Spurenelemente in der Onkologie
Authors: Holch Julian , Michl Marlies , Heinemann Volker , Erickson Nicole 
Published: June 2017

AbstractThe use of vitamins and minerals to prevent cancer as well as their supportive use in oncological patients is widespread and often occurs without the knowledge of the treating physician. Beyond general recommendations with regard to a balanced and healthy diet, no evidence exists supporting the use of vitamins and minerals in the prevention of cancer. Furthermore, the diet of oncological patients should contain vitamins and minerals of the same quantity as for healthy individuals. In particular, there is currently no rationale for a high-dosage administration of antioxidants.
Komplementärmedizin in der Onkologie – was ist sinnvoll?
Authors: Eustachi Axel , Melchart Dieter 
Published: June 2017

AbstractThe basis of any complementary therapy should be the recommendation of a healthy lifestyle (diet, nutrition, exercise, stress-reduction), and appropriate self-help techniques (e. g. thermotherapy, herbal OTC-products) aimed at releasing the patients’ most debilitating symptoms. For therapy-resistant or strong symptoms, more invasive interventions or medical treatments with an acceptable evidence base can be used (e. g. acupuncture for cancer pain, herbal prescriptions). The effects of any complementary intervention should be controlled for a period of six weeks after its administration. Patients should be advised not to use products or methods with possibly harmful side effects or negative interactions with conventional medications.
Safety and efficacy of glycopyrrolate as a premedication for endoscopic submucosal dissection: a randomized, double-blind, placebo-controlled study
Authors: Kim Eui , Um Min , Kim Kyoung , Kim Jung , Kim Su , Park Dong , Kwon Kwang , Chung Jun , Kim Yoon 
Published: June 2017

Abstract
Background and study aims Anticholinergic premedication has not been validated for endoscopic submucosal dissection (ESD). In this randomized, double-blind, placebo-controlled trial, we investigated the efficacy and safety of glycopyrrolate as a premedication for ESD.
Methods A total of 196 patients undergoing ESD at a single tertiary medical center between December 2014 and February 2016 were randomly allocated to receive one of the following two premedications: glycopyrrolate (0.004 mg/kg intramuscularly [IM]) or placebo (2.0 mL normal saline solution IM). All patients received the premedication 30 minutes prior to ESD in a double-blind manner. The endoscopists reported the ease of performing the procedure and the incidence of secretion-induced hypoxemia, cough, and other procedure-related adverse events.
Results Glycopyrrolate and placebo were received by 96 and 100 patients, respectively. ESD was successfully performed in all patients without any serious adverse events related to sedation or ESD. The median visual analog scale for procedure ease was higher in the glycopyrrolate group at 8 (interquartile range [IQR] 7 – 9) vs. 7 (IQR 6 – 8.25); P < 0.001. The proportions of patients with secretion-induced hypoxemia (4.4 % vs. 14.3 %; P = 0.03) and cough (16.7 % vs. 35.7 %; P = 0.005) were lower in the glycopyrrolate group.
Conclusions The use of glycopyrrolate as a premedication for ESD significantly improved
the ease of performing the procedure and reduced the incidence of secretion-induced hypoxemia and cough during ESD. Glycopyrrolate may be a promising premedication to ensure safe and stable ESD procedures.Trial registration: Clinical Research Information Service (CRIS): KCT0001540.
Clinical Experience With the Use of Low-Intensity Pulsed Ultrasound (LIPUS) in the Treatment of Atypical Femoral Fractures
Authors: Lee Sang Yang , Niikura Takahiro , Iwakura Takashi , Fukui Tomoaki , Kuroda Ryosuke 
Published: June 2017

Objective:
The aim of this study was to report the clinical results of atypical femoral fractures (AFFs) treated with low-intensity pulsed ultrasound (LIPUS).

Materials and Methods:
The data on AFFs that were surgically treated in our hospital from 2010 to 2016 was retrospectively analyzed. AFF was diagnosed based on the criteria defined by the second report of an ASBMR task force.

Results:
Seven fractures in 6 cases were included in this study. Two fractures were referred to us as being nonunion. Five fractures were subtrochanteric fractures and 2 fractures were shaft fractures. Five fresh AFFs were fixed with an intramedullary nail and 2 nonunion fractures were fixed with plates. LIPUS was used in 6 fractures. Bone union was achieved in 5 fractures with the average time to union being 17 months (5–29). In 4 out of the 6 fractures treated with LIPUS, bone union was achieved after 14 months on average. In the other 2 LIPUS-treated fractures, bone union was not achieved even at 1 year after surgery.

Discussion:
It is known that AFF healing tends to be very slow. Some case reports indicate that AFF healing might be accelerated by LIPUS. In the current series, the subtrochanteric fracture that was not treated with LIPUS healed at 29 months after surgery, which was much longer than the average time to union in the 5 fractures that were treated with LIPUS. Although our number of cases is small, LIPUS may be a potentially useful tool for accelerating AFF repair.
The Retrograde-Antegrade-Retrograde Technique for Successful Placement of a Retrograde Superior Ramus Screw
Authors: Weatherby David J. , Chip Routt Milton L. , Eastman Jonathan G. 
Published: June 2017

Summary:Stabilization of pelvic ring injuries and certain acetabular fractures using percutaneous techniques is becoming increasingly more common. Intramedullary superior ramus screw fixation is beneficial in both injury types. While implants can be placed in an antegrade or retrograde direction, parasymphyseal ramus fractures benefit from retrograde implant insertion. In some patients, the parabolic osseous anatomy or obstructing soft tissues of the anterior pelvis or thigh can prevent appropriate hand and instrumentation positioning for appropriate retrograde ramus screw insertion through the entire osseous fixation pathway. Instead of abandoning medullary fixation, we propose a technique utilizing cannulated screws to successfully place retrograde screws in this distinct clinical scenario.
Gottron Papules Show Histopathologic Features of Localized Lymphedema
Authors: Fernandez-Flores Angel , Cassarino David S. 
Published: June 2017

Abstract:
Although Gottron papules are a relevant feature of dermatomyositis, they are reported in very few papers in the literature, and the largest series on the subject includes 11 cases. We intend to study the main histopathologic features of Gottron papules in a series of 12 biopsies. We evaluated hematoxylin–eosin stains on all cases. We also performed histochemical stains to evaluate the dermal deposition of mucin. Finally, we studied the CD123+ cell population in the inflammatory infiltrate by immunohistochemistry. We found that the epidermis was either acanthotic or hyperplastic in all cases. We found a dermal inflammatory infiltrate in all cases but one. Mucin deposition in the reticular dermis was an inconstant feature. Vacuolization of the basal layer was also a frequent finding. There was thickening of the base membrane on periodic acid-Schiff stains in all our cases. We identified CD123+ cells in all cases but 2. Intraepidermal CD123+ cells were also found in 8 cases. All cases but one showed lymphangiectasia in the upper part of the dermis, including the papillary and reticular dermis. In addition, collapsed lymphatics were evident underlying the dermal sclerosis. We conclude that Gottron papules show typical features of localized lymphedema.
Transducing-Like Enhancer of Split 1: A Potential Immunohistochemical Marker for Glomus Tumor
Authors: Bozdogan Nazan , Dilek Gulay B. , Benzer Emine , Karadeniz Mujde , Bozdogan Onder 
Published: June 2017

Abstract:
Glomus tumors (GTs) are rare, perivascular soft tissue tumors. Although GTs are usually found in the subcutaneous tissue, they may be detected in extracutaneous sites and mucosal areas. Transducing-like enhancer of split 1 (TLE1) is a highly useful immunohistochemical marker, which basically helps in differential diagnosis of synovial sarcoma. Based on a coincidental detection of TLE1 in one GT case, we studied 26 additional GT cases to establish the importance and distribution of TLE1 in GTs. Of 24 subcutaneous GTs, 22 (91.6%) were positive for TLE1 antibody and the remaining 2 mucosal GTs were negative. Of the 22 positive cases, 10 showed strong nuclear positivity. There was no difference between the subtypes of the GTs. Although TLE1 expression is significantly correlated to SS18 (SYT) rearrangements in synovial sarcomas, the fluorescence in situ hybridization analyses of the GTs showed no evidence of translocation involving this locus. TLE1 is a potential immunohistochemical marker for GTs, but further studies are required to confirm this finding.
CONN SYNDROME PRESENTING AS CENTRAL RETINAL VEIN OCCLUSION
Authors: Atik Alp , Wilson Dennis , Essex Rohan W. 
Published: June 2017

Purpose:
To describe a case of central retinal vein occlusion in a young patient presenting with symptomatic malignant hypertension because of Conn syndrome.

Methods:
Single interventional case report.

Results:
A 44-year-old man presented with a 1-day history of headache and vision loss in his right eye on a background of malignant hypertension. He was diagnosed with right central retinal vein occlusion. Further investigation of his malignant hypertension revealed Conn syndrome because of an aldosterone-secreting adenoma in the left adrenal gland.

Conclusion:
This is the first reported case of Conn syndrome presenting as central retinal vein occlusion. Conn syndrome should be suspected in young patients with central retinal vein occlusion because it is a common cause of hypertension and carries significant cardiovascular risk if left untreated.
Oral Cholic Acid Is Efficacious and Well Tolerated in Patients With Bile Acid Synthesis and Zellweger Spectrum Disorders
Authors: Heubi James E. , Bove Kevin E. , Setchell Kenneth D.R. 
Published: June 2017

ABSTRACTObjectives:Patients with bile acid synthesis disorders (BASDs) due to single enzyme defects (SEDs) or Zellweger spectrum disorders (ZSDs) accumulate hepatotoxic atypical bile acids resulting in potentially fatal progressive liver disease. We evaluated the efficacy and safety of oral cholic acid in patients with BASD.Methods:In this phase 3, open‐label, single‐arm, nonrandomized, noncomparative study conducted over 18 years, patients were administered cholic acid orally 10 to 15 mg · kg−1 · day−1. The primary efficacy variables were changes from pre‐ to post‐treatment in atypical urinary bile acids, liver chemistries (serum aspartate aminotransferase, alanine aminotransferase), and height and weight. Additional efficacy variables included changes in serum bilirubin and liver histology.Results:Of the 85 enrolled patients (63 with SED and 22 with ZSD), 79 received at least 1 dose of study medication; 70 patients (50 with SED and 20 with ZSD) were included in the modified intent‐to‐treat dataset. Cholic acid significantly improved urine bile acid metabolite scores (P < 0.0001) and serum aspartate aminotransferase and alanine aminotransferase (P < 0.0001) in patients with SED and ZSD. Cholic acid also improved height and weight percentiles in both groups, but only the change in weight was significant (P < 0.05). Serum direct bilirubin decreased significantly post‐treatment (P < 0.001) in the intent‐to‐treat population, and liver biopsies showed either stable findings or histologic improvement in all parameters except bridging fibrosis. The overall safety profile of cholic acid was favorable, with no study drug‐related serious adverse events or drug‐related deaths reported.Conclusions:Oral cholic acid is a safe, efficacious, and well‐tolerated treatment for BASD due to SED and ZSD.
Does the corruption perception level of a country affect listed firms’ IFRS 7 risk disclosure compliance?
Authors: Agyei-Mensah Ben Kwame 
Published: June 2017

PurposeThis paper aims to examine the relationship between corporate governance, corruption and compliance with International Financial Reporting Standard (IFRS 7) risk disclosure requirements in listed firms in two Sub-Saharan Africa countries: Botswana and Ghana. This study tries to test whether the transparency level of a country has any impact on the transparency level of its firms.Design/methodology/approachThe study uses 174 firm-year observations between the period 2013-2015 for listed firms in the two countries. Each annual report was individually examined and coded to obtain the disclosure of corporate risk disclosure index. Descriptive analysis was performed to provide the background statistics of the variables examined. This was followed by regression analysis, which forms the main data analysis.FindingsThe results suggest that the extent of risk disclosure compliance over the three-year period is, on average, 63 and 53 per cent for Botswana and Ghana, respectively. The differences in the disclosure levels in the two countries can be attributed to the different levels of corruption in the two countries. One way of hiding corrupt practices is for companies to disclose scanty information.Originality/valueThis is one of the few studies in Sub-Saharan Africa that tests the transparency levels of listed firms in the two countries by considering the impact of corporate governance factors on IFRS 7 risk disclosure compliance. The findings of this study will help market regulators in Ghana, Botswana, the Sub-Saharan Africa Security and Exchange Commission (SEC) and the Sub-Saharan Africa exchanges in evaluating the adequacy of the current disclosure regulations in their countries.
Cross-level effects of HRM bundle on employee well-being and job performance
Authors: Liu Fang , Chow Irene Hau-Siu , Xiao Dan , Huang Man 
Published: June 2017

PurposeThe purpose of this paper is to examine the mediation role of psychological ownership for the organization (PO-O) in the relationships between human resource management (HRM) bundle and job satisfaction, affective commitment and job performance.Design/methodology/approachBased on multilevel data analysis, 705 employees from 162 small- and medium-sized enterprises in China, this study adopted an empirical design.FindingsPO-O mediates the relationships between HRM bundle and job satisfaction, affective commitment and job performance.Research limitations/implicationsThese findings highlight the importance of HRM bundle to contribute to employees’ feelings of ownership for the organization and their well-being and job performance. Longitudinal design and multiple sources at multi-stage for data collection in future research would be required for the further understanding of the relationships between the variables of this study. A single organizational and cultural context is not sufficient; broader testing in different organizational and cultural contexts is required.Practical implicationsManagers should develop employees’ feeling of ownership by using HRM bundle. They can thus gain a competitive advantage by enhancing employees’ skills, knowledge and abilities, as well as improving their well-being and performance.Originality/valueThis study extends the current literature by providing theoretical and empirical explanations of the mediating role of psychological ownership in the HRM bundle-employee outcomes relationship using a cross-level research design.
Social contagion or strategic choice?
Authors: Wang Min , Han Yulan , Su Yiyi 
Published: June 2017

PurposeThis paper aims to explore how Chinese negotiators’ positive and negative emotions affect value claiming during dyadic negotiations and examine the influence of these aroused emotions on the recipient as well as the antecedents and consequents of such reactions.Design/methodology/approachUsing a simulated face-to-face negotiation between buyers and sellers, the authors conducted an experiment based on the manipulation of the sellers’ emotions. About 280 undergraduates participated in a simulated negotiation. SPSS20.0 statistical analysis software was used to test the hypothesis.FindingsThe results indicated that the sellers who demonstrates negative emotions claimed more value than happy sellers (direct effect), and the perceived power disadvantage mediated this effect. Moreover, buyers in the happy dyads displayed a higher evaluation of their guanxi (relationship). This experiment also indicated that the sellers’ emotions (happiness or anger) evoked a reciprocal emotion in the buyers, supporting the social contagion perspective. More importantly, as emotion recipients, the buyers’ reactions exerted further influence on the outcomes (ripple effect); specifically, in the happy dyads, the buyers’ positive emotional reactions were negatively related to their individual gains. Finally, the buyers with low agreeableness were more likely to display negative emotional reactions.Research limitations/implicationsNegotiators should have an understanding of how emotions may shape conflict development and resolution via direct and ripple effects. In general, during Chinese negotiations, expressing anger is an effective negotiation tactic that incurs the expense of damaged relationships with counterparts.Originality/valueThe findings validated the impact of emotions in the Chinese negotiation context. Further, the paper extended the research by demonstrating the influence of emotions on the recipients’ reactions. Both the direct and ripple effect provided evidence for adopting the strategic choice perspective during negotiations.
On near-optimal deadlock control for a class of generalized Petri nets using reachability graph
Authors: Hou YiFan , Uzam Murat , Zhao Mi , Li ZhiWu 
Published: June 2017

Purpose
Deadlock is a rather undesirable phenomenon and must be well solved in flexible manufacturing systems (FMS). This paper aims to propose a general iterative deadlock control method for a class of generalized Petri nets (GPN), namely, G-systems, which can model an FMS with assembly and disassembly operations of multiple resource acquisition. When given an uncontrolled G-system prone to deadlocks, the work focuses on the synthesis of a near-optimal, non-blocking supervisor based on reachability graph (RG) analysis.

Design/methodology/approach
The concept of a global idle place (GIP) for an original uncontrolled G-system is presented. To simplify the RG computation of an uncontrolled G-system, a GIP is added temporarily to the net model during monitor computation steps. Starting with one token and then by gradually increasing the number of tokens in the GIP at each iteration step, the related net system is obtained. The minimal-covered-set of all bad markings of the related net system suffering from deadlock can be identified and then removed by additional monitors through an established place-invariant control method. Consequently, all related systems are live, and the GIP is finally removed when the non-blockingness of the controlled system is achieved. Meanwhile, the redundancy of monitors is also checked.

Findings
A typical G-system example is provided to demonstrate the applicability and effectiveness of the proposed method. Experiments show that the proposed method is easy to use and provides very high behavioral permissiveness for G-system. Generally, it can achieve an optimal or a near-optimal solution of the non-blocking supervisor.

Originality/value
In this work, the concept of GIP for G-systems is presented for synthesis non-blocking supervisors based on RG analysis. By using GIP, an effective deadlock control method is proposed. Generally, the proposed method can achieve an optimal or a near-optimal, non-blocking supervisor for an uncontrolled G-system prone to deadlocks.