bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Hospital Length of Stay and Discharge Status of Two Contemporary Primary Total Knee Systems
Authors: Etter Katherine , Lerner Jason , Kalsekar Iftekhar , de Moor Carl , Yoo Andrew , Swank Michael 
Published: August 2017

AbstractThis study compares the differences in hospital length of stay (LOS), operating room time (ORT), discharge status, and total hospital costs among primary total knee arthroplasty (TKA) patients implanted with one of two contemporary primary total knee systems. A retrospective cohort analysis of elective inpatient, primary, unilateral TKA patients in the United States from 2013 to 2014 was conducted using the Premier Perspective® hospital billing database. The included patients had a diagnosis for osteoarthritis and received an ATTUNE® Knee (Gradually Reducing Radius Knee) or Triathlon™ (Single Radius Knee) from a hospital where both devices were used. Patient, provider, and procedure characteristics were included in generalized estimating equation (GEE) models to explore the impact of device on LOS, ORT, discharge status, and costs accounting for clustering within hospitals. A 1:1 propensity score–matched sensitivity analysis was also conducted. There were 1,178 patients who received gradually reducing radius knee and 5,707 patients who received single radius knee. GEE models indicated that the adjusted mean LOS and ORT for patients who received gradually reducing radius knee were significantly shorter than those who received single radius knee (p < 0.001). The adjusted odds ratios for gradually reducing radius knee patients being discharged to a skilled nursing facility (SNF) or other facility were 39% lower than that for single radius knee patients (odds ratio = 0.61; 95% confidence interval: 0.50–0.75; p < 0.001). The adjusted mean costs for gradually reducing radius knee patients were significantly lower than the single radius knee patients ($12,824 [1,813] vs. $18,713 [1,505]; p < 0.01). Findings were similar in the propensity-matched cohort of 2,044 patients, which was balanced on baseline covariates between devices (standardized differences were ≤ 8%). Patients who received gradually reducing radius knee had a shorter LOS and ORT, were less likely to be discharged to a SNF or other facility, and had lower total hospital cost than those who received single radius knee. These outcomes are increasingly relevant as hospitals bear the financial burden for episodes of care, and will require optimization to achieve success under the Centers for Medicare and Medicaid Services' Comprehensive Care for Joint Replacement model.
Impact of Age on Patient-Reported Outcome Measures in Total Knee Arthroplasty
Authors: Townsend Luke , Roubion Ryan , Bourgeois Devin , Leonardi Claudia , Fox Rabun , Dasa Vinod , Pollock Grant 
Published: August 2017

AbstractPatient expectations and demographics are vital factors in determining patient satisfaction and outcomes from total knee arthroplasty (TKA). This study was a retrospective chart review that analyzed data from TKA patients to determine the impact of age on patient-reported outcomes measures following TKA. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Oxford knee scores were collected as primary outcome measures from 356 consecutive patients who underwent TKA. Oxford knee scores were further divided into pain and function subscores. Patients were age categorized as <50, 50 to 59, 60 to 69, 70 to 79, and >79. Preoperative scores were compared among age categories including age category, gender, body mass index (BMI), and length of stay (LOS) in the model as fixed effects. Scores collected postoperatively (∼10, 30, 90, and 180 days postoperation) were analyzed as repeated measures including age category, day and their interaction, gender, BMI, LOS, and preoperative score in the model. Preoperative OXFORD scores significantly differed among age categories (p < 0.05) and were numerically higher for the older (≥60 years old) compared with younger patients (<60 years old). After adjusting for preoperative scores, postoperative WOMAC and overall, pain, and function OXFORD scores significantly differed among the age groups (p < 0.05), with patients younger than 60 years reporting the worst scores in the postoperative time period. Older patients reported better preoperative overall, pain, and function scores and greater post-TKA outcomes than younger patients. A better understanding of factors that influence patient-reported outcomes can help providers to better manage patient expectations.
Indication for Unicompartmental Knee Replacement versus Osteotomy around the Knee
Authors: Lobenhoffer Philipp 
Published: August 2017

AbstractUnicompartmental medial or lateral osteoarthritis of the knee is found in up to 50% of all osteoarthritic patients and may be addressed surgically either by knee osteotomies or unicompartmental replacements. The limits for indicating one procedure or the other are somehow not defined. This article discusses the diagnostic algorithm and the most important decision factors. A long-leg radiograph and formal deformity analysis is mandatory. If constitutional or posttraumatic metaphyseal deformity in the frontal plane is detected and the opposite compartment is intact, an osteotomy should be considered. The result is not depending on age and grade of osteoarthritis. Unicompartmental knee arthroplasty is indicated in substantial osteoarthritis of one compartment (bone-on-bone) with intact ligaments and a functionally intact contralateral compartment. The anatomy of the femur and tibia should be normal with no gross osseous deformity. Age, obesity, or asymptomatic patellofemoral degeneration are not considered exclusion criteria for those surgical procedures.
Hoffnung für Huntington-Patienten – erste klinische
Gene-Silencing-Studie
Authors: Rollnik Jens D. 
Published: August 2017

ZusammenfassungBei der Huntington-Erkrankung handelt es sich um eine bisher nicht kausal
behandelbare neurodegenerative Erkrankung, die mit motorischen, psychiatrischen
und kognitiven Symptomen einhergehen kann.Die Ursache der in Deutschland mit einer Häufigkeit von etwa 1:10 000
auftretenden, autosomal-dominant vererbten Erkrankung, ist eine Mutation im
Huntingtin-Gen (CAG-Expansion). Diese führt zu einer Polyglutamin-Expansion im
Huntingtin-Protein (HTT). Das so veränderte HTT (mHTT) hat eine zytotoxische
Wirkung, ist schlecht löslich, neigt zur Aggregation in der Zelle und löst eine
komplexe pathophysiologische Kaskade aus, an deren Ende eine gestörte
Zellfunktion und schließlich der Zelltod stehen. In dem vorliegenden Artikel
wird das Prinzip des Gene Silencing erklärt, mit dem Transkription bzw.
Translation des Huntingtins gehemmt werden können. Ein Ansatz, der zu einer
Suppression der Translation führt, ist der Einsatz von Antisense
Oligonukleotiden (ASO), welche an prä-mRNA andocken. Eine erste klinische Studie
bei frühmanifesten Huntington-Patienten wird seit August 2015 mit ASO
(Studiensubstanz: IONIS-HTTRx) durchgeführt (NCT02519036). Auch wenn Ergebnisse
noch abgewartet werden müssen, könnte die Studie den Weg zu einer ersten
kausalen Therapie der Huntington-Erkrankung ebnen.
Drastischer Anstieg neudiagnostizierter Patienten mit
Demenz in deutschen Hausarztpraxen im Jahr 2013. Bessere Erkennung oder
finanzieller Anreiz?
Authors: Bohlken Jens , Michalowsky Bernhard , Kostev Karel 
Published: August 2017

Zusammenfassung
Hintergrund In Hausarztpraxen (HA) gab es 2013 eine drastische
Inzidenz-Zunahme von Patienten mit Demenz (PmD). Fragestellung: (1) Ist der
Anstieg auch in einer Substichprobe nachweisbar, (2) gab es einen vergleichbaren
Anstieg in Facharztpraxen (FA), (3) sind Folgen für Diagnostik und Therapie
feststellbar?
Methoden Die Analyse basiert auf Abrechnungsdaten von 874 HA- und 141
FA-Praxen (2011 bis 2015) von mehr als 14 000 PmD/Jahr. Auswertung: inzidente
Demenz-Diagnosen (ICD 10: G30, F01, F03), Antidementiva-Verordnungen.
Ergebnisse Abrupter Inzidenz-Anstieg um 47 % (2013) bzw. um 73 % (2014)
gegenüber 2012. Anteile unspezifischer und vaskulärer Demenzen-Diagnosen nahmen
zu. Anteile Alzheimer-Demenzen und Antidementiva-Verordnungen nahmen ab.
Vergleichbare Entwicklungen waren in FA-Praxen nicht feststellbar.
Schlussfolgerung Der drastische Inzidenz-Anstieg ging 2013 mit arzt- und
patientenseitigen ökonomische Anreizen einher. Ob ein ursächlicher Zusammenhang
bestand und welche Folgen der Inzidenzanstieg hat, sollte weiter untersucht
werden.
Ultraschnelle zelluläre Anpassung an Schwerelosigkeit
Authors: Thiel Cora , Hock Bertold , Ullrich Oliver 
Published: August 2017

ZusammenfassungEchtzeitmessungen auf der Internationalen Raumstation (ISS) konnten belegen, dass Zellen prinzipiell in der Lage sind, sich ultraschnell an veränderte Schwerkraftverhältnisse zu adaptieren. Im Experiment TRIPLE LUX A wurde der Einfluss von Gravitationskräften zwischen 1 und 0 g auf die Oxidative-Burst-Reaktion von NR8383-Alveolarmakrophagen untersucht. Erstmals konnte durch Echtzeit- und On-orbit-Messungen auf der ISS eine schwerkraftabhängige Reaktion in Säugerzellen direkt bewiesen und verfolgt werden. Durch den Messaufbau gelang ebenso der erstmalige Nachweis einer ultraschnellen und nach 42 Sekunden erfolgten vollständigen Anpassung einer zellulären Reaktion an die Schwerelosigkeit.
Imaging the emergence and natural progression of spontaneous autoimmune diabetes
Authors: Mohan James F. , Kohler Rainer H. , Hill Jonathan A. , Weissleder Ralph , Mathis Diane , Benoist Christophe 
Published: August 2017

Significance
Dynamics and interactions of immunocytes infiltrating the pancreas during the natural progression of autoimmune diabetes are largely unknown. The construction of diabetes-prone nonobese diabetic mice with a panel of fluorescent reporters that illume infiltrating cells of the innate and adaptive immune systems, combined with intravital imaging of the pancreas, provide novel perspectives on the autoimmune process and on the ballet between aggressive and regulatory cells.
No Evidence of Site Fidelity in Atlantic Croakers or Spot in the Shore Zone of Lower Delaware Bay
Authors: Torre Michael P. , Lifavi Danielle M. , Kaestner William P. , Targett Timothy E. 
Published: August 2017

AbstractWe conducted a mark–recapture study over a 98‐d period from June 20 through September 26, 2013, in lower Delaware Bay, USA, to examine movement and site fidelity of the Atlantic Croaker Micropogonias undulatus and Spot Leiostomus xanthurus. A secondary objective was to evaluate the effectiveness of visible implant elastomer (VIE) tagging for these species. Fish were tagged at five shore‐zone sites along approximately 5 km of gradually sloping sandy beach and at a site along 300 m of riprap‐hardened shoreline. Additional tagging occurred in an adjacent area (~36 ha) of nearshore habitat. Atlantic Croakers and Spot (15 individuals per species) were also tagged and held in the laboratory for 2 months to examine tag retention and fish survival. In total, 133 Atlantic Croakers and 253 Spot were tagged and released. The VIE tagging was shown to be a highly effective technique for studying the movement of these species; tag retention rates were 100% and 98% in Atlantic Croakers and Spot, respectively, and no mortality was observed among tagged fish held in the laboratory. No tagged fish were recaptured in shore‐zone or nearshore sampling, indicating a lack of site fidelity by either species in these habitats. These results demonstrate the need for more extensive research on the movements of shore‐zone nekton in the U.S. mid‐Atlantic region.
A novel multi-walled carbon nanotube-based antibody conjugate for quantitative and semi-quantitative lateral flow assays
Authors: Sun Wenjuan , Hu Xiaolong , Liu Jia , Zhang Yurong , Lu Jianzhong , Zeng Libo 
Published: August 2017

Abstract
In this study, the multi-walled carbon nanotubes (MWCNTs) were applied in lateral flow strips (LFS) for semi-quantitative and quantitative assays. Firstly, the solubility of MWCNTs was improved using various surfactants to enhance their biocompatibility for practical application. The dispersed MWCNTs were conjugated with the methamphetamine (MET) antibody in a non-covalent manner and then manufactured into the LFS for the quantitative detection of MET. The MWCNTs-based lateral flow assay (MWCNTs-LFA) exhibited an excellent linear relationship between the values of test line and MET when its concentration ranges from 62.5 to 1500 ng/mL. The sensitivity of the LFS was evaluated by conjugating MWCNTs with HCG antibody and the MWCNTs conjugated method is 10 times more sensitive than the one conjugated with classical colloidal gold nanoparticles. Taken together, our data demonstrate that MWCNTs-LFA is a more sensitive and reliable assay for semi-quantitative and quantitative detection which can be used in forensic analysis.
Structure, function, and regulation of enzymes involved in amino acid metabolism of bacteria and archaea
Authors: Tomita Takeo 
Published: August 2017

Abstract
Amino acids are essential components in all organisms because they are building blocks of proteins. They are also produced industrially and used for various purposes. For example, l-glutamate is used as the component of “umami” taste and lysine has been used as livestock feed. Recently, many kinds of amino acids have attracted attention as biological regulators and are used for a healthy life. Thus, to clarify the mechanism of how amino acids are biosynthesized and how they work as biological regulators will lead to further effective utilization of them. Here, I review the leucine-induced-allosteric activation of glutamate dehydrogenase (GDH) from Thermus thermophilus and the relationship with the allosteric regulation of GDH from mammals. Next, I describe structural insights into the efficient production of l-glutamate by GDH from an excellent l-glutamate producer, Corynebacterium glutamicum. Finally, I review the structural biology of lysine biosynthesis of thermophilic bacterium and archaea.
Width and string tension of the flux tube in SU(2) lattice gauge theory at high temperature
Authors: Chagdaa S , Galsandorj E , Laermann E , Purev B 
Published: August 2017

Abstract
We study the profiles of the flux tube between a static quark and an antiquark in quenched SU(2) lattice gauge theory at temperatures around the deconfinement phase transition. The physical width of the flux tube and the string tension have been determined from the transverse profiles and the

q

q

¯

potential, respectively. Exploiting the computational power of a GPU accelerator in our flux tube investigation, we achieve much higher statistics through which we can increase the signal to noise ratio of our observables in the simulation. This has allowed the investigation of larger lattices as well as larger separations between the quarks than in our previous work. The improved accuracy gives us better results for the width and the string tension. The physical width of the flux tube increases with the temperature up to around T

c
while keeping its increasing dependence on the

q

q

¯

separation. The string tension results are compared for two different sizes of the lattice. As the lattice becomes larger and finer together with the improved precision, the temperature dependent string tension tends to have a smaller value than the previous one.
Roadmap on solar water splitting: current status and future prospects
Authors: Chu Sheng , Li Wei , Yan Yanfa , Hamann Thomas , Shih Ishiang , Wang Dunwei , Mi Zetian 
Published: August 2017

Abstract
Artificial photosynthesis via solar water splitting provides a promising approach to storing solar energy in the form of hydrogen on a global scale. However, an efficient and cost-effective solar hydrogen production system that can compete with traditional methods using fossil fuels is yet to be developed. A photoelectrochemical (PEC) tandem cell consisting of a p-type photocathode and an n-type photoanode, with the photovoltage provided by the two photoelectrodes, is an attractive route to achieve highly efficient unassisted water splitting at a low cost. In this article, we provide an overview of recent developments of semiconductor materials, including metal oxides, nitrides, chalcogenides, Si, III–V compounds and organics, either as photocathodes or photoanodes for water reduction and oxidation, respectively. In addition, recent efforts in constructing a PEC tandem system for unassisted water splitting are outlined. The importance of developing a single-photon photocathode and photoanode that can deliver high photocurrent in the low bias region for efficient PEC tandem system is highlighted. Finally, we discuss the future development of photoelectrode materials, and viable solutions to realize highly efficient PEC water splitting device for practical applications.
A joint model for mixed and truncated longitudinal data and survival data, with application to HIV vaccine studies
Authors: Yu Tingting , Wu Lang , Gilbert Peter B 
Published: August 2017

SUMMARYIn HIV vaccine studies, a major research objective is to identify immune response biomarkers measured longitudinally that may be associated with risk of HIV infection. This objective can be assessed via joint modeling of longitudinal and survival data. Joint models for HIV vaccine data are complicated by the following issues: (i) left truncations of some longitudinal data due to lower limits of quantification; (ii) mixed types of longitudinal variables; (iii) measurement errors and missing values in longitudinal measurements; (iv) computational challenges associated with likelihood inference. In this article, we propose a joint model of complex longitudinal and survival data and a computationally efficient method for approximate likelihood inference to address the foregoing issues simultaneously. In particular, our model does not make unverifiable distributional assumptions for truncated values, which is different from methods commonly used in the literature. The parameters are estimated based on the h-likelihood method, which is computationally efficient and offers approximate likelihood inference. Moreover, we propose a new approach to estimate the standard errors of the h-likelihood based parameter estimates by using an adaptive Gauss–Hermite method. Simulation studies show that our methods perform well and are computationally efficient. A comprehensive data analysis is also presented.
Proteomic landscape of the primary somatosensory cortex upon sensory deprivation
Authors: Kole Koen , Lindeboom Rik G.H. , Baltissen Marijke P.A. , Jansen Pascal W.T.C. , Vermeulen Michiel , Tiesinga Paul , Celikel Tansu 
Published: August 2017

Abstract
Experience-dependent plasticity (EDP) powerfully shapes neural circuits by inducing long-lasting molecular changes in the brain. Molecular mechanisms of EDP have been traditionally studied by identifying single or small subsets of targets along the biochemical pathways that link synaptic receptors to nuclear processes. Recent technological advances in large-scale analysis of gene transcription and translation now allow systematic observation of thousands of molecules simultaneously. Here we employed label-free quantitative mass spectrometry to address experience-dependent changes in the proteome after sensory deprivation of the primary somatosensory cortex. Cortical column- and layer-specific tissue samples were collected from control animals, with all whiskers intact, and animals whose C-row whiskers were bilaterally plucked for 11–14 days. Thirty-three samples from cortical layers (L) 2/3 and L4 spanning across control, deprived, and first- and second-order spared columns yielded at least 10 000 peptides mapping to ~5000 protein groups. Of these, 4676 were identified with high confidence, and &gt;3000 were found in all samples. This comprehensive database provides a snapshot of the proteome after whisker deprivation, a protocol that has been widely used to unravel the synaptic, cellular, and network mechanisms of EDP. Complementing the recently made available transcriptome for identical experimental conditions (see the accompanying article by Kole et al.), the database can be used to (i) mine novel targets whose translation is modulated by sensory organ use, (ii) cross-validate experimental protocols from the same developmental time point, and (iii) statistically map the molecular pathways of cortical plasticity at a columnar and laminar resolution.
The Balanced Voronoi Formulas for $\textrm{GL}(n)$
Authors: Miller Stephen D , Zhou Fan 
Published: August 2017

Abstract
In this article, we show how the $\textrm{GL}(N)$ Voronoi summation formula of [13] can be rewritten to incorporate hyper-Kloosterman sums of various dimensions on both sides. This generalizes a formula for $\textrm{GL}(4)$ with ordinary Kloosterman sums on both sides that was used in [1] to prove nonvanishing of GL(4) $L$-functions by GL(2)-twists, and later by the second-named author in [16].
Cardiorespiratory Responses to Short Bouts of Resistance Training Exercises in Individuals With Chronic Obstructive Pulmonary Disease
Authors: Robles Priscila , Araujo Tamara , Brooks Dina , Zabjek Karl , Janaudis-Ferreira Tania , Marzolini Susan , Goldstein Roger , Mathur Sunita 
Published: August 2017

Purpose:
Resistance training is recommended in pulmonary rehabilitation for people with chronic obstructive pulmonary disease (COPD); however, the acute cardiorespiratory responses to different intensities of resistance training are not known. We compared acute cardiorespiratory responses with high-intensity versus low-intensity resistance exercises in persons with COPD and healthy, matched controls. This research may assist in developing training parameters in COPD.

Methods:
Participants (n = 10 per group) performed 1 set of 10 repetitions of leg extension and arm elevation at 2 intensities: 40% (low) and 80% (high) of 1-repetition maximum. Minute ventilation (

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

e), oxygen uptake (

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

o
2), and heart rate (HR) data were collected continuously and expressed as absolute values and relative to values at

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

o
2peak derived from a cardiopulmonary exercise test. Blood pressure, oxygen saturation, and rating of perceived exertion (RPE) were monitored before and after each set of exercises.

Results:
Individuals with COPD showed similar

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

e,

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

o
2, and HR with high- versus low-intensity exercises. RPE was higher after high- vs low-intensity leg extension (4 ± 1.4 vs 2 ± 1, P < .005) and arm elevation (3 ± 2 vs 1 ± 1.4, P < .005). Compared with healthy participants, relative

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

o
2,

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

e, and HR were higher in COPD (≅40% vs 20% of the

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

o
2peak; ≅60% vs 20% of

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

e
peak; and ≅80% vs 20% of HRpeak; all Ps ≤ .004). Absolute responses and RPE were similar between groups, irrespective of intensity and exercise.

Conclusion:
Immediate cardiorespiratory responses to an acute bout of resistance exercise appear to be independent of the exercise intensity in COPD. Although people with COPD are working closer to their

JOURNAL/jcprh/04.03/01273116-201709000-00011/11FSM1/v/2023-09-11T232137Z/r/image-gif

o
2peak, their responses and RPE are comparable with healthy controls.