bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fear to fail and entrepreneurship intent: examining linkages and potential pathways in Senegal
Authors: Ndour Cheikh T. , Asongu Simplice A. 
Published: September 2024

AbstractThis study aims to investigate the effect of fear of failure on entrepreneurship intent. It utilises survey data from the Global Entrepreneurship Monitor (2015) conducted in Senegal. Analysing a sample of 2364 individuals, the probit model was employed, revealing three key findings. Firstly, fear of failure significantly diminishes entrepreneurship intent. Secondly, individuals who are partially employed demonstrate a heightened inclination towards entrepreneurship. Thirdly, fear of failure consistently impacts entrepreneurship intent regardless of gender. A key policy implication of this research is the necessity to address discrimination in policies designed to support individuals with greater entrepreneurial aspirations.
Making Sense of Interlinkages in EU Marine Environment Legislation: Unearthing Effectiveness
Authors: Appleby Thomas , Scott Juliette , Flannery Wesley , Donelan Edward 
Published: September 2024

AbstractCrises such as water quality, pollution, climate change, overfishing, biodiversity, energy, waste, and carbon sequestration mean that legislation protecting the marine environment is under intense pressure to be effective and to demonstrate positive results in a vast array of public and private spheres. Thus far, scholarship of EU marine environmental law has been focused primarily on (i) interaction with international agreements (ii) spatial/jurisdictional studies (iii) analysis of new laws, plans and programmes (iv) principles (e.g. good environmental status, precautionary approach, polluter pays) (v) CJEU case analysis (vi) enforcement (vii) specific issues (plastics, litter…). However, over the years the mass constituted by the EU marine environment acquis has grown ever-larger, leading to risks of poor coordination, over-regulation in some areas and lack of regulation in others. By triangulating complementary investigatory methodologies, this study teases out systemic, diachronic and legilinguistic interlinkages—within and across key instruments as well as EU institutions, bodies and agencies. Our results provide avenues for policymakers nationally and at EU level to improve the legibility and coherence of marine environmental regulation—to the benefit of citizens and the wider body of stakeholders, and, ultimately, to benefit the marine world.
Environmental life cycle assessment of drink and yoghurt products using non-nutritive sweeteners and sweetness enhancers in place of added sugar: the SWEET project
Authors: Suckling J. , Morse S. , Murphy R. , Raats M. , Astley S. , Ciruelos A. , Crespo A. , Halford J. C. G. , Harrold J. A. , Le-Bail A. , Koukouna E. , Musinovic H. , Raben A. , Roe M. , Scholten J. , Scott C. , Westbroek C. 
Published: September 2024

Abstract

Purpose
There are increasing concerns regarding detrimental health effects of added sugar in food and drink products. Non-nutritive sweeteners (NNS) and sweetness enhancers (SE) are seen as viable alternatives. Much work has been done on health and safety of NNS&SE when consumed in place of sugar, but very little on their sustainability. This work aims to bridge that gap with an environmental study of replacing added sugar with NNS&SE in the context of drink and yoghurt.

Methods
A life cycle assessment (LCA) approach was used to compare environmental impact of a drink and yoghurt, sweetened with sucrose, to those sweetened with NNSs or an SE: stevia rebaudioside A, sucralose, aspartame, neotame, and thaumatin. Primary ingredients data were taken from preparation of foodstuffs for clinical trials. Results are reported via the ReCiPe 2016 (H) method, with focus on land use, global warming potential (GWP), marine eutrophication, mineral resource scarcity, and water consumption. Impacts are reported in terms of 1 kg product. Scenarios explore sensitivity of the LCA results to change in background processes, functional unit, and sweetener type. This research was conducted as part of the EU Horizon 2020 project SWEET (sweeteners and sweetness enhancers: impact on health, obesity, safety, and sustainability).

Results and discussion
Replacing sugar with an NNS or part-replacing with an SE is shown to reduce environmental impact across most impact categories, for example, on a mass basis, GWP for a drink reduces from 0.61 to approx. 0.51 kgCO2-eq/kg and for a yoghurt from 4.15 to approx. 3.73 kgCO2-eq/kg. Variability in environmental impact is shown to be relatively small between the NNSs, indicating that choice of NNS is less important than the reformulation changes required to accommodate the loss of sugar. Reporting impact in terms of calorie density, instead of mass, shows greater reduction in environmental impact when using an NNS or SE and shows how important functional unit is when reporting impact of these products.

Conclusion
This study is the first to compare food or drink products sweetened with sugar, NNS, or SE. Results show that there is great potential to reduce environmental impact of sweetened drinks and yoghurts. Moreover, the choice of NNS does not greatly affect the environmental impact of either product. Therefore, this research shows that choices relating to replacing added sugar may be based more upon health or formulation needs and less on environmental concerns.
Does Philosophy Make Less Progress than Other Academic Fields?
Authors: Maslen Cei 
Published: September 2024

AbstractThis paper looks at different possible measures of progress and argues that we currently have no objective measures which are appropriate for comparing the progress of entire fields. I look at several possible measures, including one measure suggested by Chalmers: increased agreement on correct answers to the big questions in that field. Regarding the question that the title of this paper asks, I think we should remain agnostic; we are not currently able to say whether philosophy makes less progress than other academic fields.
Urban Care for Unpaid Caregivers: Community Voices in the Care Block Program, in Bogotá, Colombia
Authors: Guevara-Aladino Paula , Sarmiento Olga L. , Rubio María Alejandra , Gómez-García Lina María , Doueiri Zakaria Nadeem , Martínez Diego , King Abby C. , Hurtado-Tarazona Adriana , Banchoff Ann , Guzman Luis A. , Álvarez-Rivadulla María José , Palencia Leonardo 
Published: September 2024

AbstractThe Care Block of Bogotá, Colombia, is an urban program that offers services for low-income unpaid caregivers. This study aimed to (i) characterize unpaid caregivers’ subjective well-being, mental health symptoms, physical activity levels, and use of public spaces linked to the Care Block; (ii) identify caregivers’ perceived built and social environment facilitators and barriers to accessing the Care Block facility; and (iii) document the community-led advocacy process to improve the Care Block program. The quantitative component included a subjective well-being and mental health symptoms survey, and the System for Observing Play and Recreation in Communities (SOPARC) instrument. The qualitative component included the Our Voice citizen science method augmented with portable virtual reality equipment to engage participants in advocacy for changes. Participants (median age of 53 years) dedicated a median of 13.8 h a day to unpaid caregiving, had an average subjective well-being score of 7.0, and 19.1% and 23.8% reported having depression and generalized anxiety symptoms respectively. Caregivers reported that the program fosters their perception of purpose, enjoyment, resilience, and cognitive and emotional awareness. SOPARC evaluation showed that most women engaged in moderate to vigorous physical activity. The caregivers highlighted education, physical activity services, and integration of facilities as facilitators to accessing the Care Block program. Poor quality and lack of sidewalks and roads, limited personal safety, and the risk of pedestrian-vehicle collisions were identified as barriers. Virtual Reality sparked compelling dialogue between participants and stakeholders, allowing stakeholders to reflect on an urban program facilitating unpaid care work.
Abortion Ban Advocates and Rape Exception
Authors: Dominiak Ł. 
Published: September 2024

AbstractThe present paper argues that abortion ban advocates can justify an exception for rape. Recently, Blackshaw offered an interesting argument that if abortion ban advocates modified their position along the lines of Thomson’s analysis of rights, they could make an exception for rape. However, doing so would require making concessions they would be unlikely to make, the crucial one being subscribing to an absurd view that abortion in the case of rape is permissible but only if it is performed in a certain way, that is, in a way that withdraws life support from the fetus. Agreeing first with Blackshaw’s premises, we argue that the view in question is hardly absurd. Thus, relying on Boonin’s acknowledgment that although very rare, a position according to which abortion should be legal but only if it is performed in a way that lets the fetus die rather than kills it is a possible position, we argue, first, that it is Blackshaw’s position that is inconsistent, second, that since deontology sees permissibility of a given result as path-dependent, deontologically oriented abortion ban advocates should find the view in question appealing rather than absurd and, third, that although there are indeed scenarios in which withdrawing life support is morally equivalent to killing, extraction abortions in the case of rape are not amongst them. Since in the case of rape the fetus is not entitled to life support, extraction abortions are better classified as permissible non-omissive allowings than impermissible killings. Thus, there is nothing absurd in the view that abortion in the case of rape is permissible but only if it is performed in a certain way. Accordingly, adopting this view does not seem to be much of a concession for abortion ban advocates who can therefore make an exception for rape.
Recent Updates on the Pathogenesis of Inflammatory Myopathies
Authors: Musai Jon , Mammen Andrew L. , Pinal-Fernandez Iago 
Published: September 2024

Abstract
Purpose of Review
This review aims to provide a comprehensive and updated overview of autoimmune myopathies, with a special focus on the latest advancements in understanding the role of autoantibodies. We will begin by examining the risk factors and triggers associated with myositis. Next, we will delve into recent research on how autoantibodies contribute to disease pathogenesis. Finally, we will explore the latest innovations in treatment strategies and their implications for our understanding of myositis pathogenesis.

Recent Findings
Recent research has revealed that myositis-specific autoantibodies can infiltrate muscle cells and disrupt the function of their target autoantigens, playing a crucial role in disease pathogenesis. Significant advances in treatment include CD19 CAR-T cell therapy, JAK-STAT inhibitors, and novel strategies targeting the type 1 interferon pathway in dermatomyositis. Additionally, the ineffectiveness of complement inhibitors in treating immune-mediated necrotizing myositis has challenged established views on disease mechanisms.

Summary
Autoimmune myopathies are a collection of disorders significantly influenced by specific autoantibodies that drive disease pathogenesis. This review highlights the critical role of autoantibody research in deepening our understanding of these conditions and discusses recent therapeutic advancements targeting key pathogenic pathways.
Predictive Hypoxemic Threshold for Tolerating the Apnea Test While Assessing Death by Neurological Criteria
Authors: Aviram Daniel , Hikri Daniel , Aharon Michal , Galoz Amir , Lichter Yael , Goder Noam , Nini Asaph , Adi Nimrod , Stavi Dekel 
Published: September 2024

Abstract
Background
The apnea test (AT) plays a vital role in diagnosing brain death by evaluating the absence of spontaneous respiratory activity. It entails disconnecting the patient from mechanical ventilation to raise the CO2 partial pressure and lower the pH. Occasionally, the AT is aborted because of safety concerns, such as hypoxemia and hemodynamic instability, to prevent worsening conditions. However, the exact oxygen partial pressure level needed before commencing AT, indicating an inability to tolerate the test, is still uncertain. This study seeks to determine pre-AT oxygen levels linked with a heightened risk of test failure.

Methods
We conducted a retrospective cohort study involving patients suspected of having brain death at the Tel Aviv Medical Center from 2010 to 2022. The primary outcome was defined as an arterial partial O2 pressure (PaO2) level of 60 mmHg or lower at the conclusion of the AT. This threshold is significant because it marks the point at which the saturation curve deflects, potentially leading to rapid deterioration in the patient’s oxygen saturation.

Results
Among the 70 patients who underwent AT, 7 patients met the primary diagnostic criteria. Patients with a PaO2 ≤ 60 mmHg at the conclusion of the AT exhibited a significantly lower initial median PaO2 of 243.7 mmHg compared with those with higher pre-AT PaO2 levels of 374.8 mmHg (interquartile range 104.65–307.00 and interquartile range 267.8–444.9 respectively, P value = 0.0041). Pre-AT PaO2 levels demonstrated good discriminatory ability for low PaO2 levels according to the receiver operating characteristic (ROC) curve, with an area under the curve of 0.76 (95% confidence interval 0.52–0.99).

Conclusions
PaO2 values at the conclusion of the AT are closely associated with PaO2 values at the beginning of the test. Establishing a cutoff value of approximately 300 mmHg PaO2 at the onset of AT may assist in avoiding saturation drops below 90%.
Analysis of genomic alternations in epidermal growth factor receptor (EGFR)-T790M-mutated non-small cell lung cancer (NSCLC) patients with acquired resistance to osimertinib therapy
Authors: Hsu Ping-Chih , Chang John Wen-Cheng , Chiu Li-Chung , Yang Cheng-Ta , Kuo Scott Chih‐Hsi , Fang Yueh-Fu , Wu Chiao-En 
Published: September 2024

Abstract
Background and objectives
Genomic alterations after resistance to osimertinib therapy in advanced T790M-mutated non-small cell lung cancer (NSCLC) are complex and poorly understood. In this study, we aimed to detect these genomic alternations via comprehensive next-generation sequencing (NGS) of tissue and liquid biopsies.

Patients and methods
From September 2020 to June 2021, 31 stage IIIB/IV T790M-mutated NSCLC patients who exhibited progressive disease after osimertinib therapy and provided written informed consent were recruited. Liquid and tissue biopsy samples for NGS testing were collected from 31 and 18 patients, respectively. Eighteen study patients had paired NGS data from tissue and liquid biopsies.

Results
With respect to the T790M mutation status, the preservation and loss rates were 33% and 67%, respectively, in both liquid and tissue biopsy samples. Five patients (16.1%) had the C797S mutation (4 liquid samples and 1 tissue sample). Two (6.5%) had MET mutations, 3 (9.7%) had BRAF-V600E mutations, and 1 (3.2%) had a KRAS-G12C mutation. Among the 18 patients who underwent tissue rebiopsies, those with preserved T790M mutation had significantly longer progression-free survival (PFS) with osimertinib therapy than those with T790M mutation loss (10.8 vs. 5.0 months, P = 0.045). Among all patients, those with T790M mutation loss in liquid biopsy samples had longer PFS after osimertinib therapy (10.8 vs. 7.5 months, P = 0.209) and postprogression survival (17.7 vs. 9.6 months, P = 0.132) than those with preserved T790M mutation based on liquid biopsies.

Conclusions
NGS using either tissue or liquid biopsy samples from advanced T790M-mutated NSCLC patients with acquired resistance to osimertinib therapy can detect various genomic alternations. Future studies focusing on subsequent tailored therapies on the basis of NGS results are warranted.
The Effect of a Mindfulness Course on Self-Compassion Among Occupational Therapy Students
Authors: Tal-Saban Miri , Biran Sigal , Fogel-Grinvald Haya , Golos Anat 
Published: September 2024

Abstract
Objectives
This study examined the impact of a mandatory course teaching mindfulness skills to first-year occupational therapy (OT) students' mindfulness skills and self-compassion. The objectives were to assess: (a) the correlations between students' mindfulness and self-compassion skills before and after participating in the course; and (b) the differences in mindfulness and self-compassion skills among the OT students who completed the mindfulness course.

Method
A cross-sectional, comparative, and correlation study design involved 106 first-year undergraduate OT students during three academic years, who participated in a mindfulness course. The students completed the Kentucky Inventory of Mindfulness Skills (KIMS) and the Self-Compassion Scale (SCS) before and after completing an academic semester.

Results
High and significant correlations were found between mindfulness skills and self-compassion total scores before versus. after completing the course. The post-scores of all the KIMS facets, besides “Acting”, were higher than the pre-scores; these differences were found to be significant for the total score, and for “Observing” and “Accepting” subscales. Significant improvement was also found in the SCS total score, and in all SCS components besides “Common Humanity”.

Conclusions
This study provides insights into the impact of a mandatory course teaching mindfulness and self-compassion skills to a large group of first-year undergraduate OT students. The results highlight the need to integrate mindfulness training into the curricula of health professions, such as OT. Practicing mindfulness and self-compassion may contribute to the personal and professional development of health profession students, as well as enhancing their ability to cope with academic pressures and challenges.

Preregistration
This study is not preregistered.
Dynamic Change Characteristics of Wetlands in Hefei and their Driving Factors Along the Urban–Rural Gradient
Authors: Zhang Hui , Li Chuntao , Zhang Yichen , Zhang Lang 
Published: September 2024

AbstractWetlands, as vital components of urban ecological infrastructure, provide essential ecosystem services. However, they face increasing risks of degradation and loss due to their vulnerability, environmental changes, and human activities. Therefore, effective restoration efforts are urgently needed. This study adopts a novel approach by considering the urban–rural gradient and integrates land use data, ecological parameters, and anthropogenic factors in Hefei City. Through morphological spatial pattern analysis, principal component analysis, and affinity propagation, this study identifies and analyzes urban–rural gradients. Using the optimal parameter geographic detector, the drivers of wetland changes from 1990 to 2020 are quantitatively assessed across different urban–rural gradients in Hefei. The findings indicate the following. (1) A persistent reduction in wetland expanse throughout the study duration, diminishing from 1274.56 km2 in 1990 to 1119.37 km2 in 2020, constituting a decrement of 12.17%. (2) Based on geographic detector outcomes, disparate driving forces underpin wetland dynamics across urban–rural gradients, with urban locales predominantly influenced by organic carbon and the proportion of impervious surface factors. Meanwhile, in agricultural and semi-ecological villages, silt is the primary factor, while ecological villages are primarily modulated by both silt and gross domestic product factors. Additionally, synergistic interactions manifest heightened explanatory power. This study elucidates the mechanistic underpinnings of wetland dynamics along urban–rural gradients, providing pivotal insights for developing targeted wetland restoration and conservation policies pertinent to the urban–rural developmental trajectory in Hefei City. Concurrently, it offers relevant recommendations for the multifaceted stewardship and sustainable development of wetlands in Hefei City in the foreseeable future.
Effective Treatment of Primary Orbital Squamous Cell Carcinoma with Radiotherapy: A Rare Case Report and Literature Review Update
Authors: Nath Jyotiman , Das Abhinandan , Saha Debasmita , Ahmed Shiraj , Kakati Kaberi , Dutta Anamika 
Published: September 2024

AbstractPrimary squamous cell carcinoma (SCC) of the orbit is exceptionally rare, comprising only a small fraction of ocular tumours, with most cases being secondary to tumours originating from nearby structures or due to distant metastasis. We present a case of primary orbital SCC in a 60-year-old male, discussing its diagnostic workup, imaging findings, and multidisciplinary management. The patient underwent definitive radiotherapy with concurrent chemotherapy after being deemed inoperable. Without any severe treatment-related adverse event, the patient achieved a complete metabolic response at 7 months post-treatment with maintained vision. As evident from a review of the literature, treatment approaches vary widely in this group of patients, with radiotherapy emerging as a successful modality in achieving disease control while preserving vision with acceptable toxicity. This case underscores the complexity of managing primary orbital SCCs and highlights the efficacy of radiotherapy in achieving favourable outcomes.
Gender differences in neurocognitive assessments: insights from a pilot study with the International Neurocognitive Test Profile (INCP) digital battery
Authors: Maierhofer Bernd , Grigoryeva Daria , Beck Beatrice , Lehrner Johann 
Published: September 2024

Summary
Background
The aging global population has led to an increase in the number of dementia diagnoses, with projections indicating a continued upward trend. This demographic change presents profound challenges for patients, their families, and healthcare systems worldwide. Consequently, the demand for reliable and user-friendly screening tools that can detect dementia at early stages and monitor its progression is more critical than ever. The International Neurocognitive Test Profile (INCP), developed at the Medical University of Vienna, aims to address this need by offering a digital test battery for the early detection of dementia. This study forms a part of the INCP’s ongoing development and evaluation, specifically investigating the influence of gender on test outcomes.

Methods
Seventy participants, recruited through flyers at the Vienna General Hospital, completed the INCP assessment using tablets as part of the study. The effect of gender on performance across various INCP subtests was analyzed using Mann–Whitney U tests. For further exploratory analysis, a correlation matrix was calculated encompassing demographic variables (age and education), screening data, and all INCP subtests.

Results
The analysis revealed significant gender differences in two INCP subtests related to executive functions. Males outperformed females on the Figure Fluency Test (r = 0.30, indicating a moderate effect) and the Dice 2‑n Back Test (r = 0.29, indicating a small effect). However, when correcting for multiple comparisons, no significant gender disparities were observed in the scores of the subtests.

Conclusion
The identification of possible gender differences in specific subtests underscores the importance of considering gender as a variable in the further development and evaluation of the INCP. These findings offer valuable insights for the design and planning of future studies involving the INCP.