bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Einsteinian no-signalling violated in Bell tests?
Authors: Kupczynski Marian 
Published: November 2017

Abstract
Relativistic invariance is a physical law verified in several domains of physics. The impossibility of faster than light influences is not questioned by quantum theory. In quantum electrodynamics, in quantum field theory and in the standard model relativistic invariance is incorporated by construction. Quantum mechanics predicts strong long range correlations between outcomes of spin projection measurements performed in distant laboratories. In spite of these strong correlations marginal probability distributions should not depend on what was measured in the other laboratory what is called shortly: non-signalling. In several experiments, performed to test various Bell-type inequalities, some unexplained dependence of empirical marginal probability distributions on distant settings was observed. In this paper we demonstrate how a particular identification and selection procedure of paired distant outcomes is the most probable cause for this apparent violation of no-signalling principle. Thus this unexpected setting dependence does not prove the existence of superluminal influences and Einsteinian no-signalling principle has to be tested differently in dedicated experiments. We propose a detailed protocol telling how such experiments should be designed in order to be conclusive. We also explain how magical quantum correlations may be explained in a locally causal way.
Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model. Preliminary results on differential conductivity
Authors: Pañella Clara , Castellví Quim , Moll Xavier , Quesada Rita , Villanueva Alberto , Iglesias Mar , Naranjo Dolores , Sánchez-Velázquez Patricia , Andaluz Anna , Grande Luís , Ivorra Antoni , Burdío Fernando 
Published: November 2017

Abstract

Background
Spread hepatic tumours are not suitable for treatment either by surgery or conventional ablation methods. The aim of this study was to evaluate feasibility and safety of selectively increasing the healthy hepatic conductivity by the hypersaline infusion (HI) through the portal vein. We hypothesize this will allow simultaneous safe treatment of all nodules by irreversible electroporation (IRE) when applied in a transhepatic fashion.

Material and methods
Sprague Dawley (Group A, n = 10) and Athymic rats with implanted hepatic tumour (Group B, n = 8) were employed. HI was performed (NaCl 20%, 3.8 mL/Kg) by trans-splenic puncture. Deionized serum (40 mL/Kg) and furosemide (2 mL/Kg) were simultaneously infused through the jugular vein to compensate hypernatremia. Changes in conductivity were monitored in the hepatic and tumour tissue. The period in which hepatic conductivity was higher than tumour conductivity was defined as the therapeutic window (TW). Animals were monitored during 1-month follow-up. The animals were sacrificed and selective samples were used for histological analysis.

Results
The overall survival rate was 82.4% after the HI protocol. The mean maximum hepatic conductivity after HI was 2.7 and 3.5 times higher than the baseline value, in group A and B, respectively. The mean maximum hepatic conductivity after HI was 1.4 times higher than tumour tissue in group B creating a TW to implement selective IRE.

Conclusions
HI through the portal vein is safe when the hypersaline overload is compensated with deionized serum and it may provide a TW for focused IRE treatment on tumour nodules.
Mechanical alloying of CuFe-alumina nanocomposite: study of microstructure, corrosion, and wear properties
Authors: Baghani Mohammad , Aliofkhazraei Mahmood , Seyfoori Amir , Askari Mehdi 
Published: November 2017

Abstract
The effects of adding Al2O3 nanoparticles on the microstructure, tribological, magnetic, and corrosion properties of CuFe-Al2O3 nanocomposites were investigated in this work. The mixture of Cu-25 wt.% Fe powder with 5 vol.% Al2O3 was mechanically milled. X-ray diffraction results revealed that after 60 h of mechanical alloying, CuFe solid solution was formed. Magnetic hysteresis loops of the mechanically alloyed powders were extracted at room temperature. The morphology and elemental analysis of the sintered specimens were studied by field emission scanning electron microscope (SEM). It was observed that uniform distribution and embedding of Al2O3 nanoparticles in the CuFe alloy matrix in nanocomposites were achieved, which exhibited excellent performances. Tribological properties were evaluated through a pin-on-disk wear test, and it was found that by the addition of Al2O3 nanoparticles to CuFe alloy, the weight loss rate was reduced by 30%. The existence of Al2O3 nanoparticles in the matrix of CuFe alloy causes the wear mechanism change from adhesive to abrasive, which means a considerable wear resistance was obtained in nanocomposites. The corrosion properties of the sintered samples in a solution of 3.5% NaCl were studied by potentiodynamic polarization. With the addition of Al2O3 nanoparticles, the corrosion rate of the alloy was reduced by 75%.
Conceptual study for long-term monitoring of chemotherapeutic induced cell reactions by ESPI
Authors: Gottschalk Josefine Johanna , Stollfuß Carsten , Lietzau Kai-Henning , Foitzik Andreas H. , Richetta Maria 
Published: November 2017

Abstract
During the last years, various approaches on an individualized drug therapy for benign cells have been
researched. However, due to the complex topic a universal approach has not been found up until this point. Commonly, the
effect of cytotoxic drugs on benign cells is in most cases the same compared to regular cells while the actual effect on
patient still can't be predicted. In order to reduce unwanted side effects or unspecific drug reactions a test system for
patients which allows to analyse the interaction between cytotoxic agents and the targeted cells is needed. Furthermore,
this should also include an adequate measurement system which is capable to work in a natural environment and without any
additional preparation. In terms of this work, a first proof of concept with different benign cells and cytotoxic agents
is presented while monitoring the obtained displacement using electronic speckle pattern interferometry (ESPI).
Justice, Gender, and Corporations. Outline of a Feminist Political Philosophy of the Corporation
Authors: Hamrouni Naïma , Néron Pierre-Yves 
Published: November 2017

AbstractCorporations, as institutions that participate in the creation and perpetuation of gender-based injustices, have been neglected by feminist political philosophers and egalitarians in general. However, since gender-based inequalities within the family, the market, and in democratic participation are interconnected, critically scrutinizing institutions such as corporate organizations appears to be essential in order to achieve gender justice. This is our goal in this paper. In the first part, we look at the (surprising) domination of the ethics of care in the feminist literature on corporations. Since it focuses essentially on the goal of developing virtuous managers, we conclude that this ethics of care is misleading when it comes to thinking about the kinds of relations that characterize corporations and their much needed organizational transformation. In the second part, we attempt to highlight and articulate more explicitly the need for a critical analysis of corporations from the point of view of gender justice. Finally, having shown how purely “distributive” approaches of gender justice are unsatisfactory, we finish by outlining a multidimensional approach to gender (in)justice within and by corporate organizations. We do so by drawing on the insights of distributive, participatory, and relational accounts of equality.
Sesquiterpenes from the Saudi Red Sea: Litophyton arboreum with their cytotoxic and antimicrobial activities
Authors: Abou El-Kassem Lamia T. , Hawas Usama W. , El-Desouky Samy K. , Al-Farawati Radwan 
Published: November 2017

Abstract
A new pseudoguaiane-type sesquiterpene named litopharbol (1) was isolated from the methanolic extract of the Red Sea soft coral Litophyton arboreum, along with known sesquiterpenoids alismol (2), alismorientol B (3), teuhetenone A (4), and calamusin I (5); steroid, 24-methyl-cholesta-5,24(28)-diene-3β-ol (6), alkyl glyceryl ether, chimyl alcohol (7); sphingolipid, erythro-N-dodecanoyl-docosasphinga-(4E,8E)-dienine (8); and nitrogenous bases, thymine (9) and thymidine (10). The structures were determined on the basis of nuclear magnetic resonance (NMR) spectroscopic (1D and 2D NMR data including heteronuclear single quantum coherence spectroscopy, heteronuclear multiple-bond correlation spectroscopy, and nuclear Overhauser effect spectroscopy) and mass spectrometric analyses. Compounds 1–5 were explored for antimicrobial activity and cancer cell line sensitivity tests. Compound 1 exhibited antibacterial activity against Bacillus cereus with a minimum inhibition concentration of 1.8 μg/mL, whereas compound 3 showed significant potent cytotoxic effect against MCF-7 (breast cancer cells) with IC50 4.32 μM.
Physiological and Performance Effects of Caffeine Gum Consumed During a Simulated Half-Time by Professional Academy Rugby Union Players
Authors: Russell Mark , Reynolds Nicholas A. , Crewther Blair T. , Cook Christian J. , Kilduff Liam P. 
Published: November 2017

Abstract
Russell, M, Reynolds, NA, Crewther, BT, Cook, CJ, and Kilduff, L. Physiological and performance effects of caffeine gum consumed during a simulated half-time by professional academy rugby union players. J Strength Cond Res 34(1): 145–151, 2020—Despite the prevalence of caffeine (CAF) as an ergogenic aid, few studies have examined the use of caffeinated gums, especially during half-time in team sports. The physiological (blood lactate and salivary hormone concentrations) and performance (repeated sprints and cognitive function) effects of consuming CAF gum during a simulated half-time were examined. Professional academy rugby union players (n = 14) completed this double-blind, randomized, counterbalanced study. After pre-exercise measurements, players chewed a placebo (PLC) gum for 5 minutes before a standardized warm-up and completing repeated sprint testing (RSSA1). Thereafter, during a 15-minute simulated half-time period, players chewed either CAF (400 mg; 4.1 ± 0.5 mg·kg−1) or PLC gum for 5 minutes before completing a second repeated sprint test (RSSA2). Blood lactate, salivary testosterone and cortisol concentrations, and indices of cognitive function (i.e., reaction time and Stroop test) were measured at baseline, pre-RSSA1, post-RSSA1, pre-RSSA2, and post-RSSA2. Sprint performance was not affected by CAF (p = 0.995) despite slower sprint times after the first sprint of both RSSA tests (all p < 0.002). After half-time, salivary testosterone increased by 70% (+97 ± 58 pg·ml−1) in CAF vs. PLC (p < 0.001), whereas salivary cortisol remained unchanged (p = 0.307). Cognitive performance was unaffected by time and trial (all p > 0.05). Although performance effects were absent, chewing CAF gum increased the salivary testosterone concentrations of professional rugby union players over a simulated half-time. Practitioners may, therefore, choose to recommend CAF gum between successive exercise bouts because of the increases in salivary testosterone observed; a variable associated with increased motivation and high-intensity exercise performance.
Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis
Authors: Shrestha Archana , Karmacharya Biraj Man , Khudyakov Polyna , Weber Mary Beth , Spiegelman Donna 
Published: November 2017

Abstract

Objectives
The translation of lifestyle intervention to improve glucose tolerance into the workplace has been rare. The objective of this meta-analysis is to summarize the evidence for the effectiveness of dietary interventions in worksite settings on lowering blood sugar levels.

Methods
We searched for studies in Pub-Med, Embase, Econlit, Ovid, Cochrane, Web of Science, and Cumulative Index to Nursing and Allied Health Literature. Search terms were as follows : (1) Exposurebased: nutrition/diet/dietary intervention/health promotion / primary prevention / health behavior / health education/food /program evaluation; (2) Outcome-based: diabetes/hyperglycemia/glucose/HbA1c/glycated hemoglobin; and (3) Setting-based: workplace/worksite/occupational/industry/job/employee. We manually searched review articles and reference lists of articles identified from 1969 to December 2016. We tested for between-studies heterogeneity and calculated the pooled effect sizes for changes in HbA1c (%) and fasting glucose (mg/dl)using random effect models for meta-analysis in 2016.

Results
A total of 17 articles out of 1663 initially selected articles were included in the meta-analysis. With a random-effects model, worksite dietary interventions led to a pooled −0.18% (95% CI, −0.29 to −0.06; P&lt;0.001) difference in HbA1c. With the random-effects model, the interventions resulted in 2.60 mg/dl lower fasting glucose with borderline significance (95% CI: −5.27 to 0.08, P= 0.06). In the multivariate meta-regression model, the interventions with high percent of female participants and that used the intervention directly delivered to individuals, rather the environment changes, were associated with more effective interventions.

Conclusion
Workplace dietary interventions can improve HbA1c. The effects were larger for the interventions with greater number of female participants and with individual-level interventions.
New Epidemiologic Data Regarding Hepatitis C Virus Infection in Romania
Authors: Manuc Mircea , Preda Carmen M. , Popescu Corneliu P. , Baicuș Cristian , Voiosu Theodor , Pop Corina S. , Gheorghe Liana , Sporea Ioan , Trifan Anca , Tanțău Marcel , Tanțău Alina , Ceaușu Emanoil , Proca Doina , Constantinescu Ileana , Ruta Simona M. , Fulger Larisa E. , Diculescu Mircea , Oproiu Alexandru 
Published: November 2017

Background & Aims: Literature data suggest that HCV genotype-1b is present in 93-99% of the Romanian patients infected with hepatitis C virus (HCV). We present the genotyping tests recently performed on patients with HCV and advanced fibrosis eligible for the Direct-Acting Antiviral (DAA) therapy, as well as the prevalence of these cases across Romania.Methods: The genotyping method was performed on 7,421 HCV patients with advanced fibrosis. The detection method was automatic real time PCR platform M2000 (Abbott). Every subject was introduced into a database including age, sex, county and address.Results: Genotype 1b was almost exclusively present: 7,392/7,421 (99.6%). Genotype 1b patients were 19.6% from Bucharest, 49% were males, with a median age of 60 years. Genotype non-1b was encountered in 29/7,421 subjects (0.4%), 62% were males, 69% from Bucharest and the median age was 52 years. Most of the subjects (75%) were in the 6th and 7th age decade. The prevalence of these cases varied significantly across Romanian counties: the highest was in Bucharest (61.3/105), Bihor (47/105), Iasi (46/105) and Constanța (43/105), and the lowest in Ilfov (2.8/105), Harghita (3.7/105), Covasna (5.4/105) and Maramureș (8.8/105) (p<0.001).Conclusions: Genotype 1b is encountered in 99.6% of patients with chronic hepatitis C and advanced fibrosis from Romania. The presence of genotypes non-1b is more common in Bucharest, in males and at a younger age. There are significant differences regarding the distribution of these cases across Romania: the highest rates are in Bucharest, Bihor, Iasi and Constanta.Abbreviations: BMI: body mass index; DAA: direct-acting antiviral agent; GT: genotype; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; IDU: intravenous drug users; MELD: model for end stage liver disease; NASH: non-alcoholic steatohepatitis; SVR; sustained virologic response.
PPIs Prevent Aspirin-Induced Gastrointestinal Bleeding Better than H2RAs. A Systematic Review and Meta-analysis
Authors: Szabó Imre L. , Mátics Robert , Hegyi Péter , Garami Andras , Illés Anita , Sarlós Patricia , Bajor Judit , Szűcs Ákos , Mosztbacher Dóra , Márta Katalin , Szemes Kata , Csekő Kata , Kővári Bálint , Rumbus Zoltán , Vincze Áron 
Published: November 2017

Background & Aims: Aspirin is one of the most widely used medication for its analgesic and anti-platelet properties and thus a major cause for gastrointestinal (GI) bleeding. This study compared the preventive effect of histamine-2 receptor antagonists (H2RAs) and proton-pump inhibitors (PPIs) against chronic low-dose aspirin (LDA)-related GI bleeding and ulcer formation.Methods: Electronic databases of Pubmed, Embase and Cochrane Central Register of Controlled Trials were searched for human observations (randomised controlled trials and observational studies) comparing the long term effects of PPIs and H2RAs treatment in the prevention of GI bleeding or ulcer formation in patients on chronic LDA treatment listed up till September 30, 2016. Two independent authors searched databases using PICO questions (aspirin, H2RA, PPI, GI bleeding or ulcer), and reviewed abstracts and articles for comprehensive studies keeping adequate study quality. Data of weighted odds ratios were statistically evaluated using Comprehensive Metaanalysis (Biostat, Inc., Engelwood, MJ, USA), potential bias was checked.Results: Nine studies for GI bleeding and eight studies for ulcer formation were found meeting inclusion criteria, altogether 1,879 patients were included into review. The H2RAs prevented less effectively LDA-related GI bleeding (OR= 2.102, 95% CI: 1.008-4.385, p<0.048) and ulcer formation (OR= 2.257, 95% CI: 1.277-3.989, p<0.005) than PPIs.Conclusion: The meta-analysis showed that H2RAs were less effective in the prevention of LDA-related GI bleeding and ulcer formation suggesting the preferable usage of PPIs in case of tolerance.Abbreviations: COX -1: cyclooxygenase-I enzyme; COX-2: cyclooxygenase-II enzyme; GI: gastrointestinal; H2RA(s): histamine-2 receptor antagonist(s); H. pylori: Helicobacter pylori; LDA: low dose aspirin; NSAID(s): non-steroid anti-inflammatory drug(s); OR: Odds ratio; PPI(s): proton-pump inhibitor(s); RCT: randomized controlled trial; RR: relative risk; UGIB: upper gastrointestinal bleeding.
Nodule-in-Nodule Imaging Pattern in Hepatocellular Carcinoma Treated by Transarterial Chemoembolization – a Multiparametric Magnetic Resonance Imaging Study
Authors: Scheau Andreea E. , Scheau Cristian , Lupescu Ioana G. 
Published: November 2017

Background & Aims: Emerging minimally invasive treatments for hepatocellular carcinoma (HCC) can significantly improve a patient’s prognosis, but they may alter the imaging features of the treated nodules. This study focuses on a series of patients presenting with a rare pathology, the nodule-in-nodule imaging pattern of HCC, analyzes the imaging features and discusses possible approaches for the diagnosis of tumoral recurrence.Method: Nine patients recruited over two years, having HCC with nodule-in-nodule imaging pattern on diagnosis, and treated by transarterial chemoembolization were monitored by magnetic resonance imaging (MRI). Nodule morphology, dynamic contrast behavior and size progression were followed in this study.Results: All patients showed tumor recurrence. In 7 nodules, a T2 weighted-imaging hyperintense signal of the HCC foci was found, with isointensity of the background nodule. Restricted diffusion within the HCC foci was found in 6 cases but with no statistical significance. Dynamic contrast images evaluation showed a “classical” enhancement pattern in five patients. All nodules had hypointense HCC foci in the hepatobiliary phase. Four patients demonstrated progressive disease according to the mRECIST criteria.Conclusions: Due to the particularly challenging nodule characteristics, the sensitivity in diagnosing HCC foci in these nodules is about 77% when using conventional imaging criteria related to nodule morphology. Contrast media uptake curves may be altered by changes in nodule hemodynamics caused by embolization. The diagnostic rate may be significantly increased by considering the tumoral size increase in follow-up studies and completing the study with a hepatobiliary phase using Acidum Gadoxeticum.Abbreviations. ADC: Apparent diffusion coefficient; CT: Computed tomography; DEB-TACE: drug-eluting beads transarterial chemoembolization; DWI: Diffusion-weighted imaging; Gd-EOB-DTPA: acidum gadoxeticum; HCC: hepatocellular carcinoma; HBV: hepatitis virus B; HCV: hepatitis virus C; HDV: hepatitis virus D; IN-OPP: in-phase and out-of-phase; mRECIST: modified Response Evaluation Criteria in Solid Tumors; MRI: Magnetic resonance imaging; ROI: region of interest; TACE: Transarterial chemoembolization; WI: weighted imaging.
Adherence to an Acotiamide Therapeutic Regimen Improves Long-Term Outcomes in Patients with Functional Dyspepsia
Authors: Shinozaki Satoshi , Osawa Hiroyuki , Sakamoto Hirotsugu , Hayashi Yoshikazu , Miura Yoshimasa , Lefor Alan Kawarai , Yamamoto Hironori 
Published: November 2017

Background & Aims: Long-term outcomes in patients with functional dyspepsia remain elusive. Acotiamide, a prokinetic drug, has been available in Japan since 2013. The aim of this study was to assess long-term outcomes in patients with functional dyspepsia treated with acotiamide.Methods: We retrospectively reviewed 79 consecutive patients with functional dyspepsia whose symptoms improved with acotiamide therapy and who were followed for more than one year. All patients underwent esophagogastroduodenoscopy prior to acotiamide therapy. The mean follow-up was 1.9 (range, 1.0-3.3) years. We assessed the patients’ symptom severity using the Izumo scale, which reflects changes in various abdominal symptoms.Results: At one year, dyspepsia symptoms recurred in 25% (20/79) of the patients. In multivariate analysis, severe dyspepsia was significantly associated with increased recurrence (odds ratio [OR] 15.04, 95% confidence interval [CI] 1.73-130.47, p=0.013). Continued use of acotiamide for one year diminished the recurrence of dyspepsia symptoms significantly (OR 0.16, 95%CI 0.04-0.61, p=0.006). The influence of these significant predictors on long-term outcomes was analyzed using the Kaplan-Meier method. Patients with severe dyspepsia before starting acotiamide had significantly more recurrences than those with mild symptoms (p=0.004, log-rank test). Patients who continued acotiamide therapy throughout the follow-up period had significantly fewer recurrences than those who stopped therapy (p<0.001).Conclusions: Over the long-term, patients with functional dyspepsia have a considerable rate of recurrence of dyspepsia. Severe dyspepsia before treatment increases the recurrence rates, while adherence to an acotiamide therapeutic regimen decreases recurrence rate.Abbreviations: QOL: quality of life; EPS: epigastric pain syndrome; PDS: postprandial distress syndrome; EGD: esophagogastroduodenoscopy; GERD: gastroesophageal reflux disease.