bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial
Authors: de Oliveira Hugo Goulart , Cruz Fernanda Ferreira , Antunes Mariana Alves , Macedo Neto Amarilio Vieira , Oliveira Guilherme Augusto , Svartman Fabio Munhoz , Borgonovo Tamara , Rebelatto Carmen Lucia Kuniyoshi , Weiss Daniel J. , Brofman Paulo Roberto Slud , Morales Marcelo Marcos , Lapa e Silva José Roberto , Rocco Patricia Rieken Macedo 
Published: March 2017

Abstract
One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients. However, local inflammation may result and can contribute to worsening of clinical status in these patients. We hypothesized that combined EBV insertion and intrabronchial administration of mesenchymal stromal cells (MSCs) would decrease the inflammatory process, thus mitigating EBV complications in severe COPD patients. This initial study sought to investigate the safety of this approach. For this purpose, a phase I, prospective, patient-blinded, randomized, placebo-controlled design was used. Heterogeneous advanced emphysema (Global Initiative for Chronic Lung Disease [GOLD] III or IV) patients randomly received either allogeneic bone marrow-derived MSCs (108 cells, EBV+MSC) or 0.9% saline solution (EBV) (n = 5 per group), bronchoscopically, just before insertion of one-way EBVs. Patients were evaluated 1, 7, 30, and 90 days after therapy. All patients completed the study protocol and 90-day follow-up. MSC delivery did not result in acute administration-related toxicity, serious adverse events, or death. No significant between-group differences were observed in overall number of adverse events, frequency of COPD exacerbations, or worsening of disease. Additionally, there were no significant differences in blood tests, lung function, or radiological outcomes. However, quality-of-life indicators were higher in EBV + MSC compared with EBV. EBV + MSC patients presented decreased levels of circulating C-reactive protein at 30 and 90 days, as well as BODE (Body mass index, airway Obstruction, Dyspnea, and Exercise index) and MMRC (Modified Medical Research Council) scores. Thus, combined use of EBV and MSCs appears to be safe in patients with severe COPD, providing a basis for subsequent investigations using MSCs as concomitant therapy.
Determination of surface ζ‐potential and isoelectric point of carbon surfaces using tracer particle suspensions
Authors: Vasconcelos Joana M. , Zen Federico , Stamatin Serban N. , Behan James A. , Colavita Paula E. 
Published: March 2017

Carbon materials are widely used in a range of applications from biomaterials to sensing and electronics. Many of these applications rely on the ability to control carbon/water interfacial properties, in particular, surface charge density. This work reports a study of the electrokinetic properties of amorphous carbon thin films as a function of pH and surface chemistry. Surface ζ‐potential (SZP) and isoelectric point were determined using the tracer particle method. Initially, the use of sulfonated and amine‐terminated latex bead suspensions as tracer particles for the determination of SZP of reference polymer surfaces was validated. The tracer particle method was then applied to the determination of SZP and isoelectric point of macroscopic carbon surfaces with different surface chemistry. Highly graphitic and sp3‐rich hydrogenated carbon surfaces were found to display negative SZP, as expected for hydrophobic surfaces. The isoelectric point of the most highly graphitic surface was found to be pHiso = 3.7. Surface oxidation of these films resulted in a decrease of SZP at all pH values and in a downshift of pHiso to values lower than 1.5, consistently with the presence of surface acidic groups arising from oxidation. Results indicate that the specific choice of acid/base chemistry for the tracer particles does not significantly affect either SZP or pHiso determinations. These results show that the tracer particle method in combination with widely available latex beads as tracers can be applied for the determination of carbon SZP as a function of pH. Copyright © 2017 John Wiley & Sons, Ltd.
Retraction: Moment–curvature response of engineered cementitious composites under cyclic loading
Authors: Zhang Wei , Yan Jia‐Bao 
Published: March 2017

The above article, published online on 10th March 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Luc Taerwe, and John Wiley & Sons Ltd. The retraction has been agreed because this work has already been published in two Japanese language publications authored by Ms Yuka Onizuka who led the research:Yuka Onizuka and Toshiyuki Kanakubo. Evaluation of the Flexural Performance of DFRCC Subjected to Cyclic Loading, Proceedings of the Japan Concrete Institute, Vol.31, No.2, pp.1315–1320, 2009.7; available on http://data.jci-net.or.jp/data_pdf/31/031-01-2220.pdf (Japan Concrete Institute web site; http://data.jci-net.or.jp/data_html/31/031-01-2220.html) (written in Japanese)Yuka Onizuka. Study on Tensile Stress – Strain Model of ECC, Master Program Thesis, Graduate School of Systems and Information Engineering, University of Tsukuba, 2010.3; available on http://www.kz.tsukuba.ac.jp/~kanakubo/onimas.pdf (written in Japanese)REFERENCEZhang W and Yan J‐B. Moment‐curvature response of engineered cementitious composites under cyclic loading, Struct. Concr. 2017. https://doi.org/10.1002/suco.201600113
Experts on the past, working in the present: what archeologists can contribute to current water management
Authors: Holt Emily 
Published: March 2017

By definition, archeologists study the past—often the ancient past—and their work may not seem relevant to present‐day problems in water management. However, the knowledge of both past practices and current conditions that archeologists gain through conducting research can have useful contemporary applications. The archeological conference Water and Power in Past Societies, held at the University at Buffalo in April 2015, highlighted these potential contributions in a panel discussion on ‘what archaeology can contribute to contemporary water politics.’ The main theme to emerge from the discussion was that archeologists’ varied experiences make them well suited to inform and facilitate dialogue among conflicting perspectives. This opinion piece summarizes and builds on the themes of the panel discussion to outline ways in which archeologists may contribute to solving current water issues.WIREs Water2017, 4:e1215. doi: 10.1002/wat2.1215This article is categorized under:Human Water > MethodsEngineering Water > Planning WaterHuman Water > Water GovernanceHuman Water > Water as Imagined and Represented
Genome shuffling of Colletotrichum lini for improving 3β,7α,15α-trihydroxy-5-androsten-17-one production from dehydroepiandrosterone
Authors: Sun Jin , Li Hui , Ni Yu , Zhang Xiaomei , Shi Jinsong , Xu Zhenghong 
Published: March 2017

Abstract
3β,7α,15α-Trihydroxy-5-androsten-17-one (7α,15α-diOH-DHEA) is a key intermediate of the novel oral contraceptive Yasmin. It can be catalyzed from dehydroepiandrosterone (DHEA) through Colletotrichum lini. Improvement of 7α,15α-diOH-DHEA production was performed through recursive protoplast fusion of C. lini ST in a genome shuffling format. 7α,15α-diOH-DHEA yield of the best performing recombinant C. lini ST-F307 reached 6.08 g/L from 10 g/L DHEA, and this was 94.9% higher than that of the initial C. lini ST strain. Through optimized conditions, the 7α,15α-diOH-DHEA yield was increased to 9.32 g/L from 12 g/L DHEA, with 1.5% ethanol as cosolvent. This is the highest reported substrate concentration and 7α,15α-diOH-DHEA production with one-step substrate addition. Moreover, C. lini ST-F307 showed high P450 enzyme activity and gene transcript levels of several cytochrome P450s, and this might contribute to the enhancement of 7α,15α-diOH-DHEA production. Genome shuffling was an efficient approach to breed high-yield strains.
Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents
Authors: Piska Kamil , Koczurkiewicz Paulina , Bucki Adam , Wójcik-Pszczoła Katarzyna , Kołaczkowski Marcin , Pękala Elżbieta 
Published: March 2017

SummaryAnthracycline antibiotics (ANT), such as doxorubicin or daunorubicin, are a class of anticancer drugs that are widely used in oncology. Although highly effective in cancer therapy, their usefulness is greatly limited by their cardiotoxicity. Possible mechanisms of ANT cardiotoxicity include their conversion to secondary alcohol metabolites (i.e. doxorubicinol, daunorubicinol) catalyzed by carbonyl reductases (CBR) and aldo-keto reductases (AKR). These metabolites are suspected to be more cardiotoxic than their parent compounds. Moreover, overexpression of ANT-reducing enzymes (CBR and AKR) are found in many ANT-resistant cancers. The secondary metabolites show decreased cytotoxic properties and are more susceptible to ABC-mediated efflux than their parent compounds; thus, metabolite formation is considered one of the mechanisms of cancer resistance. Inhibitors of CBR and AKR were found to reduce the cardiotoxicity of ANT and the resistance of cancer cells, and therefore are being investigated as prospective cardioprotective and chemosensitizing drug candidates. In this review, the significance of a two-electron reduction of ANT, including daunorubicin, epirubicin, idarubicin, valrubicin, amrubicin, aclarubicin, and especially doxorubicin, is described with respect to toxicity and efficacy of therapy. Additionally, CBR and AKR inhibitors, including monoHER, curcumin, (−)-epigallocatechin gallate, resveratrol, berberine or pixantrone, and their modulating effect on the activity of ANT is characterized and discussed as potential mechanism of action for novel therapeutics in cancer treatment.
Big Questions and Big Data: The Role of Labour and Labour Relations in Recent Global Economic History
Authors: van Nederveen Meerkerk Elise 
Published: March 2017

AbstractThis article argues that global labour history (GLH) and global economic history have much to offer each other. GLH would do well to raise sweeping questions – for instance about the origins of global inequality – engage more with theory, and increasingly use quantitative methods. Instead of seeing labour and labour relations as historical phenomena to be explained, they can serve as importantexplanatory variablesin historical analyses of economic development and divergence. In turn, economic historians have much to gain from the recent insights of global labour historians. GLH offers a more inclusive and variable usage of the concept of labour, abandoning, as it does, the often narrow focus on male wage labour in the analyses of many economic historians. Moreover, GLH helps to overcome thinking in binary categories, such as “free” and “unfree” labour. Ultimately, both fields will benefit from engaging in joint debates and theories, and from collaboration in collecting and analysing “big data”.
Fv/Fm acclimation to the Mediterranean summer drought in two sympatric Lasallia species from the Iberian mountains
Authors: VIVAS M. , PÉREZ-ORTEGA S. , PINTADO A. , SANCHO L. G. 
Published: March 2017

AbstractPhotosynthetic performance in lichens can vary throughout the year. We investigate the variation in the PSII quantum efficiency as a proxy for the physiological state of the photosynthetic apparatus in two umbilicate species from the genus Lasallia. Temporal variation in Fv/Fm in both species was monitored at a field site in Central Spain where both species coexist. Subsequent measurements were carried out in the laboratory after 48 h preconditioning. Both species showed clear variation during the year in PSII performance, with a marked depression in Fv/Fm during the summer. Lasallia pustulata consistently had higher Fv/Fm values than L. hispanica. Both species reached higher Fv/Fm values after 48 h of preconditioning in the laboratory and this recovery was particularly notable in the summer months. Fv/Fm was highly related to antecedent weather conditions during the two days prior to measurement.
Evacuation Preparedness in the Event of Fire in Intensive Care Units in Sweden: More is Needed
Authors: Löfqvist Erika , Oskarsson Åsa , Brändström Helge , Vuorio Alpo , Haney Michael 
Published: March 2017

AbstractIntroductionHospitals, including intensive care units (ICUs), can be subject to threat from fire and require urgent evacuation.HypothesisThe hypothesis was that the current preparedness for ICU evacuation for fire in the national public hospital system in a wealthy country was very good, using Sweden as model.MethodsAn already validated questionnaire for this purpose was adapted to national/local circumstances and translated into Swedish. It aimed to elicit information concerning fire response planning, personnel education, training, and exercises. Questionnaire results (yes/no answers) were collected and answers collated to assess grouped responses. Frequencies of responses were determined.ResultsWhile a written hospital plan for fire response and evacuation was noted by all responders, personnel familiarity with the plan was less frequent. Deficiencies were reported concerning all categories: lack of written fire response plan for ICU, lack of personnel education in this, and lack of practical exercises to practice urgent evacuation in the event of fire.ConclusionsThese findings were interpreted as an indication of risk for worse consequences for patients in the event of fire and ICU evacuation among the hospitals in the country that was assessed, despite clear regulations and requirements for these. The exact reasons for this lack of compliance with existing laws was not clear, though there are many possible explanations. To remedy this, more attention is needed concerning recognizing risk related to lack of preparedness. Where there exists a goal of high-quality work in the ICU, this should include general leadership and medical staff preparedness in the event of urgent ICU evacuation.LöfqvistE, OskarssonA, BrändströmH, VuorioA, HaneyM. Evacuation preparedness in the event of fire in intensive care units in Sweden: more is needed. Prehosp Disaster Med. 2017;32(3):317–320.
Overcoming Peak Overlaps in Titanium- and Vanadium-Bearing Materials with Multiple Linear Least Squares Fitting
Authors: Mengason Michael , Ritchie Nicholas 
Published: March 2017

AbstractThe evolution of the energy dispersive spectrometer (EDS) from the lithium-drifted silicon detector [Si(Li)] to the silicon drift detector (SDD) has created new opportunities in the field of electron probe X-ray microanalysis. The SDD permits operation at significantly higher count rates than the Si(Li) and also provides a more stable energy scale. X-ray spectra captured by EDS can now be analyzed qualitatively or quantitatively under the same beam conditions as used for wavelength dispersive spectrometry (WDS). Standards-based quantitative EDS (SB-Quant-EDS) can thus provide analyses that are accurate and precise for an ever growing number of materials measurement problems. In this study, we analyze NIST research glasses with “known” nominal concentrations of titanium (Ti) and vanadium (V) to evaluate the external reproducibility of the SB-Quant-EDS technique in the presence of severe peak overlaps. We additionally analyze several naturally occurring oxide minerals by WDS and EDS simultaneously and evaluate the outputs of these two methods when quantifying the same analytical volume within the sample.
Does Safeguards Need Saving? Lessons from the Ukraine–Passenger Cars Dispute
Authors: GNUTZMANN-MKRTCHYAN AREVIK , LESTER SIMON 
Published: March 2017

AbstractThe Panel Report in Ukraine–Passenger Cars provides an opportunity to revisit an old debate over the role of safeguard measures in the WTO. With regard to the legal findings, the Panel followed the established jurisprudence in this area, and found a number of violations of the Safeguards Agreement. With regard to the economics, we delve more deeply into the economic and political background of the safeguards investigation. Ukraine was hit by the economic crisis shortly after its WTO accession that significantly liberalized import tariffs on passenger cars. Next, we offer a de novo look at the injury and causation issues in this case, and discuss the challenges of an industry reliant on offshored production that sees a safeguard as a mechanism to attract foreign direct investment (FDI) for production. We conclude with an assessment of the operation of the WTO's safeguards regime, along with some tentative suggestions for reform. Overall, our examination of the economic analysis by the investigating authority and the legal review by the WTO Panel raises questions about particular aspects of the domestic and WTO processes, but concludes that the system worked well in this case.
Trade and Agricultural Disease: Import Restrictions in the Wake of the India–Agricultural Products Dispute
Authors: SAGGI KAMAL , WU MARK 
Published: March 2017

AbstractTrade in agricultural products raises sensitivities, particularly when imports originate from a trading partner experiencing an outbreak of some type of agricultural disease. In this article, we explain why despite the negative externalities associated with diseased imports, an importing country is generally not permitted to ban such imports outright under WTO law. Rather, it is allowed to do so only under specific circumstances. We also highlight how the recent India–Agricultural Products ruling contributes to the jurisprudence of two issues concerning the SPS Agreement: the interpretation of international standards, and the relationship between the risk assessment and scientific evidence requirements.
Ask for the Moon, Settle for the Stars: What is a Reasonable Period to Comply with WTO Awards?
Authors: MAVROIDIS PETROS C. , MEAGHER NIALL , PRUSA THOMAS J. , YANGUAS TATIANA 
Published: March 2017

AbstractThe World Trade Organization (WTO) dispute settlement process allows a defending Member a ‘reasonable period of time’ (RPT) to implement any findings that its contested measures are inconsistent with WTO law. If agreement on this RPT cannot be reached, Article 21.3(c) of the Understanding on Rules and Procedures Governing the Settlement of Disputes (DSU) provides for the possibility of arbitration on the length of the RPT. The DSU provides limited guidelines on the RPT, stating only that it should not normally exceed 15 months. In practice, Arbitrators have developed the standard that the RPT should reflect the shortest possible period under the domestic legal system of the defending Member to make the changes necessary to comply with the WTO rulings. Our research confirms that in practice Arbitrators have determined this period by ‘splitting the difference’ approximately between the periods suggested by the complaining and defending Member. In addition, the process appears to reward defending Members that request an RPT that exceeds the 15-month guideline in Article 21.3(c).
Tape: Or, Rewinding the Phonographic Regime
Authors: BOHLMAN ANDREA F. , McMURRAY PETER 
Published: March 2017

AbstractMagnetic tape follows the contours of the twentieth century in striking ways, from the overtly sonic and musical to less obvious political and social transformations. This introductory article sets the tone for this special issue, an effort to connect discrete histories of tape through a focus on its materialities. We posit the existence of a phonographic regime that coheres around a loose set of assumptions that often appear in tandem with broad claims about what ‘sound recording’ or even ‘analogue media’ are. This regime dates back to the invention of phonography but persists through many contemporary histories of sound recording. We challenge the regime by thinking with and through tape recording. One of tape's critical media operations, ‘rewind’, serves as a central focus for our push-back against the regime. As a button-interface, it highlights the physical engagement of humans with materialities, including the corporal labours of using technology, with iconography that digital technologies still employ. As a mechanism of respooling, it points to the industrial histories of various spooling forerunners from textiles to film reels. As we explore its cultural techniques in musical practices, we consider rewind, above all, as a temporal gesture that offers new paths backward into history.
Relays: Audiotape, Material Affordances, and Cultural Practice
Authors: KANE BRIAN 
Published: March 2017

AbstractThis article considers the relationship between audiotape's material affordances and the audibility of cultural practices. Not all changes in the materiality of sound media are audible to listeners, and not all changes in the audibility of cultural practices require changes in their material support. Thus focus on the affordances of sound technologies – those possibilities of sound technologies that may or may not be engaged by its users, and the wide range of practices that such technologies support – can help to connect materiality and audibility. I address the affordances of audiotape by examining a number of small case studies where established sonic practices encounter a transition from phonography to audiotape: musique concrète and the tape loop, serialist composition, and Les Paul's use of overdubbing. Finally, I consider the nature of the audiotape archive and its mode of access in order to pose some general questions about the meaning and use of audiotape's affordances.
Making Tapes in Poland: The Compact Cassette at Home
Authors: BOHLMAN ANDREA F. 
Published: March 2017

ABSTRACTThis article offers a history of the compact cassette in Poland from 1963 to 2015, focusing on its vibrant presence as the medium of choice for unofficial musical culture. I explore tapes’ capacity to reveal a history of everyday musical and technological fluencies: as a sonic archive they offer a window into networked epistemologies of sound under state socialism. Listening to homemade tapes – a process that builds on ethnographic encounters with their makers – I explore the work we can hear across the medium's noisy recordings and stress their position at the crossroads of musicology's methodologies. Tape's reusability, so carefully explained in historical anecdotes and technical manuals in the 1960s, facilitated democratic debate for the social movements of the 1980s. The format's fungibility and plurality made it not only a convenient conduit for discussion, but also a medium that – in form and substance – modelled the importance of dissent, revision, and return in political discourse.
Finding Meaning in the Struggle of Work
Authors: Highhouse Scott , Nye Christopher D. , Matthews Russell A. 
Published: March 2017

Abstract. It is suggested that work importance research has suffered from construct proliferation, and that the literature would benefit from returning to Dubin’s (1956) original notion of work importance as a general construct – representing the degree to which work plays a central role in one’s life space. Measures of three work importance constructs (i.e., work involvement, job involvement, work ethic endorsement) were administered to (n = 758) working adults from the USA to examine dimensionality using bifactor analysis. Results showed the bifactor model fit the data better than a one-factor or three-factor model. The bifactor model suggests that both general and domain-specific factors appear to exist, but that the general work importance factor predicts most work outcomes to a substantial degree.