bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slavery in Today’s Brazil: Law and Public Policy
Authors: Figueira Ricardo Rezende , Esterci Neide 
Published: April 2017

The abolition of slavery in 1888 failed to eliminate the repressive and compulsory use of labor in Brazil. When pressure to reduce slave trafficking made African labor scarce, coffee producers in São Paulo recruited European migrants to replace it. Through indebtedness and compulsory work, migrants became captive to the landowners who hired them. As the occupation of the Amazon frontier became state policy in the 1960s, debt bondage was used against the thousands of migrant workers hired to clear the areas for agribusiness projects. Slavery had been prohibited since 1940, and in 1965 the Congress entered into two international agreements on slavery that included debt bondage. With the end of the military government in 1985, the category “slave labor” was incorporated into the regulatory framework for employment practices, and since then it has been broadened to include labor forced by violence, debt bondage, exhausting labor, and degrading working conditions. Tensions around the definition remain, however, and prosecutions under the law and guilty verdicts have so far been few. A abolição da escravatura em 1888 não eliminou o uso repressivo e compulsório da mão-de-obra no Brasil. Em oposição ao esforço de redução do tráfico negreiro, produtores de café em São Paulo recrutaram imigrantes europeus para substituírem a mão-de-obra africana. Por meio de dívida e trabalho compulsório, imigrantes tornaram-se cativos dos senhores de terra que os contratavam. À medida que a ocupação da fronteira amazônica transformou-se em política de Estado nos anos de 1960, a peonagem foi usada contra milhares de trabalhadores migrantes contratados para o desflorestamento necessário a empreendimentos agrícolas. A escravidão havia sido proibida desde 1940 e em 1965 o Congresso aderiu a dois acordos internacionais que coibiam a peonagem e o trabalho escravo. Com o fim da ditadura militar em 1965, a categoria “trabalho escravo” foi incorporada à estrutura regulatória das práticas de emprego. Desde então, essa categoria foi ampliada, abarcando trabalho forçado por violência, peonagem, trabalho exaustivo e condições degradantes de trabalho. Contudo, há tensões remanescentes sobre essa definição. Ademais, processos, e condenações, no âmbito jurídico por violação da lei permanecem raros.
The evolution of FTSE 250 boards of directors: key factors influencing board performance and effectiveness
Authors: Long Tracy 
Published: April 2017

Although the Combined Code (Financial Reporting Council, 2003, 2006) clearly identifies the roles and responsibilities of PLC board members, current academic literature offers little guidance to FTSE 250 boards – many of whom are managing different issues compared with their FTSE 100 counterparts including high corporate growth, existing founder and/or family board members, and/or newly formed boards – on ways in which they can improve the quality of decision-making, increase individual board contribution, and enhance overall board performance and effectiveness. This paper attempts to outline the key issues faced by board members, particularly non-executive directors, serving on FTSE 250 company boards with regard to three distinct roles – strategy, succession planning and risk management – and examines the relevant influences on board members derived from corporate lifecycle, board structure, existing process and board culture which affect board performance and standards of corporate governance. Its conclusions draw on the author's previous research on non-executive contribution (Long, 2004) and her recent experience of reviewing performance and effectiveness of FTSE 100 and 250 boards of directors through Boardroom Review.
Activity Level and Function 2 Years After Anterior Talofibular Ligament Repair: A Comparison Between Arthroscopic Repair and Open Repair Procedures
Authors: Li Hong , Hua Yinghui , Li Hongyun , Ma Kui , Li Shengkun , Chen Shiyi 
Published: April 2017

Background: The open modified Broström anatomic repair technique is widely accepted as the reference standard for lateral ankle stabilization. Despite recent increases in publications regarding arthroscopic repair of the anterior talofibular ligament (ATFL) for treatment of chronic ankle instability, research is lacking that compares the functional outcomes between arthroscopic repair and open repair procedures for chronic ankle instability. Purpose: To compare function and activity level after arthroscopic repair versus open repair of the ATFL in patients with lateral ankle instability. Study Design: Cohort study; Level of evidence, 3. Methods: All patients who underwent arthroscopic or open surgical Broström repair of the ATFL between January 2012 and August 2014 were invited to participate in this study. All of the patients had consented for arthroscopic repair if feasible. In cases in which arthroscopic repair was impossible, the open modified Broström procedure was performed after arthroscopy. Patients accepted a systematic rehabilitation program postoperatively. American Orthopaedic Foot and Ankle Society (AOFAS) score, Karlsson Ankle Functional Score (KAFS), and Tegner activity score were used to evaluate ankle function preoperatively and at a minimum follow-up of 2 years. Magnetic resonance imaging (MRI) was performed to evaluate the signal to noise ratio (SNR) of the repaired ATFL. Results: A total of 60 patients were included in this study. They were assigned to 1 of 2 groups according to their surgical procedure: 23 patients underwent arthroscopic repair (arthroscopic group) and 37 patients underwent open repair (open group). No patient in either group had ankle instability at follow-up postoperatively. After surgery, the AOFAS score ( P < .001), KAFS ( P < .001), and Tegner activity score ( P < .001) increased significantly in both groups. However, no significant difference was found in AOFAS score (93.3 ± 8.9 vs 92.4 ± 8.6; P = .7), KAFS (90.3 ± 12.5 vs 89.4 ± 10.6; P = .75), and Tegner score (5 ± 2 vs 5 ± 2; P = .61) between the arthroscopic group and the open group, respectively. As well, no significant difference was found in the mean SNR value of ATFL between the arthroscopic group and the open group (9.1 ± 2.7 vs 8.8 ± 2.3; P = .39, respectively). Conclusion: When compared with open lateral ankle repair, arthroscopic repair of lateral ankle ligament when feasible produced similarly favorable outcomes. Arthroscopic ATFL repair, as a minimally invasive technique, provided favorable outcomes.
A Cluster Randomized Controlled Trial of the MyFamilyPlan Online Preconception Health Education Tool
Authors: Batra Priya , Mangione Carol M. , Cheng Eric , Steers W. Neil , Nguyen Tina A. , Bell Douglas , Kuo Alice A. , Gregory Kimberly D. 
Published: April 2017

Purpose: To evaluate whether exposure to MyFamilyPlan—a web-based preconception health education module—changes the proportion of women discussing reproductive health with providers at well-woman visits. Design: Cluster randomized controlled trial. One hundred thirty participants per arm distributed among 34 clusters (physicians) required to detect a 20% change in the primary outcome. Setting: Urban academic medical center (California). Participants: Eligible women were 18 to 45 years old, were English speaking, were nonpregnant, were able to access the Internet, and had an upcoming well-woman visit. E-mail and phone recruitment between September 2015 and May 2016; 292 enrollees randomized. Intervention: Intervention participants completed the MyFamilyPlan module online 7 to 10 days before a scheduled well-woman visit; control participants reviewed standard online preconception health education materials. Measures: The primary outcome was self-reported discussion of reproductive health with the physician at the well-woman visit. Self-reported secondary outcomes were folic acid use, contraceptive method initiation/change, and self-efficacy score. Analysis: Multilevel multivariate logistic regression. Results: After adjusting for covariates and cluster, exposure to MyFamilyPlan was the only variable significantly associated with an increase in the proportion of women discussing reproductive health with providers (odds ratio: 1.97, 95% confidence interval: 1.22-3.19). Prespecified secondary outcomes were unaffected. Conclusion: MyFamilyPlan exposure was associated with a significant increase in the proportion of women who reported discussing reproductive health with providers and may promote preconception health awareness; more work is needed to affect associated behaviors.
Pharmacist and Technician Perceptions of Tech-Check-Tech in Community Pharmacy Practice Settings
Authors: Frost Timothy P. , Adams Alex J. 
Published: April 2017

Objective: Tech-check-tech (TCT) is a practice model in which pharmacy technicians with advanced training can perform final verification of prescriptions that have been previously reviewed for appropriateness by a pharmacist. Few states have adopted TCT in part because of the common view that this model is controversial among members of the profession. This article aims to summarize the existing research on pharmacist and technician perceptions of community pharmacy–based TCT. Data Sources: A literature review was conducted using MEDLINE (January 1990 to August 2016) and Google Scholar (January 1990 to August 2016) using the terms “tech* and check,” “tech-check-tech,” “checking technician,” and “accuracy checking tech*.” Data Synthesis: Of the 7 studies identified we found general agreement among both pharmacists and technicians that TCT in community pharmacy settings can be safely performed. This agreement persisted in studies of theoretical TCT models and in studies assessing participants in actual community-based TCT models. Pharmacists who had previously worked with a checking technician were generally more favorable toward TCT. Conclusion: Both pharmacists and technicians in community pharmacy settings generally perceived TCT to be safe, in both theoretical surveys and in surveys following actual TCT demonstration projects. These perceptions of safety align well with the actual outcomes achieved from community pharmacy TCT studies.
Advanced MRI techniques: biomarkers in neuropsychiatric lupus
Authors: Sarbu N , Toledano P , Calvo A , Roura E , Sarbu M I , Espinosa G , Lladó X , Cervera R , Bargalló N 
Published: April 2017

Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients without NPSLE and 20 healthy controls. We used visual scales to evaluate atrophy and white matter hyperintensities, voxel-based morphometry and Freesurfer to measure brain volume, plus diffusion-tensor imaging (DTI) to assess white matter (WM) and gray matter (GM) damage. We compared the groups and correlated MRI abnormalities with clinical data. Results NPSLE patients had less GM and WM than controls ( p = 0.042) in the fronto-temporal regions and corpus callosum. They also had increased diffusivities in the temporal lobe WM ( p < 0.010) and reduced fractional anisotropy in the right frontal lobe WM ( p = 0.018). High clinical scores, longstanding disease, and low serum C3 were associated with atrophy, lower fractional anisotropy and higher diffusivity in the fronto-temporal lobes. Antimalarial treatment correlated negatively with atrophy in the frontal cortex and thalamus; it was also associated with lower diffusivity in the fronto-temporal WM clusters. Conclusions Atrophy and microstructural damage in fronto-temporal WM and GM in NPSLE correlate with severity, activity and the time from disease onset. Antimalarial treatment seems to give some brain-protective effects.
Anti-ribosomal P antibody: a multicenter study in childhood-onset systemic lupus erythematosus patients
Authors: Valões C C M , Molinari B C , Pitta A C G , Gormezano N W S , Farhat S C L , Kozu K , Sallum A M E , Appenzeller S , Sakamoto A P , Terreri M T , Pereira R M R , Magalhães C S , Ferreira J C O A , Barbosa C M , Gomes FH , Bonfá E , Silva C A ,   Brazilian Childhood-onset Systemic Lupus Erythematosus Group
Published: April 2017

Objectives Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering the interpretation of the clinical and laboratorial associations. Therefore, the objective of this multicenter cohort study was to evaluate demographic, clinical/laboratorial features, and disease damage score in cSLE patients with and without the presence of anti-P antibody. Methods This was a retrospective multicenter study performed in 10 pediatric rheumatology services of São Paulo state, Brazil. Anti-P antibodies were measured by ELISA in 228 cSLE patients. Results Anti-P antibodies were observed in 61/228 (27%) cSLE patients. Frequencies of cumulative lymphadenopathy (29% vs. 15%, p = 0.014), acute confusional state (13% vs. 5%, p = 0.041), mood disorder (18% vs. 8%, p = 0.041), autoimmune hemolytic anemia (34% vs. 15%, p = 0.001), as well as presence of anti-Sm (67% vs. 40%, p = 0.001), anti-RNP (39% vs. 21%, p = 0.012) and anti-Ro/SSA antibodies (43% vs. 25%, p = 0.016) were significantly higher in cSLE patients with anti-P antibodies compared to those without these autoantibodies. A multiple regression model revealed that anti-P antibodies were associated with autoimmune hemolytic anemia (odds ratio (OR) = 2.758, 95% confidence interval (CI): 1.304–5.833, p = 0.008) and anti-Sm antibody (OR = 2.719, 95% CI: 1.365–5.418, p = 0.004). The SLICC/ACR damage index was comparable in patients with and without anti-P antibodies ( p = 0.780). Conclusions The novel association of anti-P antibodies and autoimmune hemolytic anemia was evidenced in cSLE patients and further studies are necessary to determine if anti-P titers may vary with this hematological manifestation.
Eversion Strength and Surface Electromyography Measures With and Without Chronic Ankle Instability Measured in 2 Positions
Authors: Donnelly Lindsy , Donovan Luke , Hart Joseph M. , Hertel Jay 
Published: April 2017

Background: Individuals with chronic ankle instability (CAI) have demonstrated strength deficits compared to healthy controls; however, the influence of ankle position on force measures and surface electromyography (sEMG) activation of the peroneus longus and brevis has not been investigated. The purpose of this study was to compare sEMG amplitudes of the peroneus longus and brevis and eversion force measures in 2 testing positions, neutral and plantarflexion, in groups with and without CAI. Methods: Twenty-eight adults (19 females, 9 males) with CAI and 28 healthy controls (19 females, 9 males) participated. Hand-held dynamometer force measures were assessed during isometric eversion contractions in 2 testing positions (neutral, plantarflexion) while surface sEMG amplitudes of the peroneal muscles were recorded. Force measures were normalized to body mass, and sEMG amplitudes were normalized to a resting period. Results: The group with CAI demonstrated less force when compared to the control group ( P < .001) in both the neutral and plantarflexion positions: neutral position, CAI: 1.64 Nm/kg and control: 2.10 Nm/kg) and plantarflexion position, CAI: 1.40 Nm/kg and control: 1.73 Nm/kg). There were no differences in sEMG amplitudes between the groups or muscles ( P > .05). Force measures correlated with both muscles’ sEMG amplitudes in the healthy group (neutral peroneus longus: r = 0.42, P = .03; plantarflexion peroneus longus: r = 0.56, P = .002; neutral peroneus brevis: r = 0.38, P = .05; plantarflexion peroneus longus: r = 0.40, P = .04), but not in the group with CAI ( P > .05). Conclusions: The group with CAI generated less force when compared to the control group during both testing positions. There was no selective activation of the peroneal muscles with testing in both positions, and force output and sEMG activity was only related in the healthy group. Clinical relevance: Clinicians should assess eversion strength and implement strength training exercises in different sagittal plane positions and evaluate for other pathologies that may contribute to reduced eversion strength in patients with CAI. Level of Evidence: Level III, cross-sectional
Dose-finding study comparing three treatments of remifentanil in cats anesthetized with isoflurane undergoing ovariohysterectomy
Authors: Machado Marcela L , Soares João Henrique N , Kuster de Albuquerque Gress Maria Alice , dos Santos e Castro Douglas , Teodoro Rosa Kaleizu , Bauer de Araujo Doria Phillipe , Otero Ascoli Fabio 
Published: April 2017

Objectives Three infusion rates of remifentanil were used in isoflurane-anesthetized cats undergoing ovariohysterectomy. The aim of this study was to identify a dosage regimen that would provide optimal anesthetic and surgical conditions, as well as to compare cardiovascular response to surgical stimulation, postoperative analgesia, anesthetic duration and quality of recovery among the tested remifentanil infusion rates. Methods Twenty-seven client-owned, mixed-breed adult healthy female cats were randomized to receive remifentanil 0.1 µg/kg/min (REMI01), remifentanil 0.2 µg/kg/min (REMI02) or remifentanil 0.4 µg/kg/min (REMI04). After premedication with acepromazine and induction of anesthesia with propofol, cats were mechanically ventilated and anesthesia was maintained at approximately 1.0 minimum alveolar concentration (MAC) of isoflurane (1.63% end-tidal isoflurane [ETISO]). Remifentanil infusion rate was increased or decreased by 20% if blood pressure had increased or decreased by 20% from previous values. Pulse rate (PR), systolic arterial pressure (SAP), esophageal temperature, pulse oximetry, end-tidal partial pressure of CO2 and ETISO were recorded at different time points during surgery. Meloxicam was administered before the end of surgery. Data within each treatment group were analyzed using a mixed-model ANOVA and Friedman’s test followed by the Wilcoxon signed rank test. Bonferroni or Dunnett’s post-hoc tests were used. The Kruskal-Wallis test followed by Dunn’s post-hoc test were used to compare data between groups; significance was set at P <0.05. Results Time to sternal recumbency and time to standing were significantly longer in REMI04 than in the other groups. SAP was higher when compared with baseline in REMI01 and REMI02 groups than in REMI04. No significant difference in PR among groups was observed. One cat in REMI01 and another in REMI02 required postoperative rescue analgesia. Conclusion and relevance The dosage regimen of 0.4 µg/kg/min seemed to be the most appropriate to be used in cats undergoing ovariohysterectomy and anesthetized with 1.0 MAC of isoflurane.
Composite MRI measures and short-term disability in patients with clinically isolated syndrome suggestive of MS
Authors: Bommarito Giulia , Bellini Alessandro , Pardini Matteo , Solaro Claudio , Roccatagliata Luca , Laroni Alice , Capello Elisabetta , Mancardi Giovanni Luigi , Uccelli Antonio , Inglese Matilde 
Published: April 2017

Background: The use of composite magnetic resonance imaging (MRI) measures has been suggested to better explain disability in patients with multiple sclerosis (MS). However, little is known about the utility of composite scores at the earliest stages of the disease. Objective: To investigate whether, in patients with clinically isolated syndrome (CIS), a composite MRI measure, rather than the single metrics, would explain conversion to MS and would better correlate with disability at baseline and at 1 year of follow-up. Methods: Corticospinal tract (CST), corpus callosum (CC) and optic radiation (OR) volume, fractional anisotropy (FA), and mean diffusivity (MD) values were measured in 27 CIS patients and 24 healthy controls (HCs). Z-scores of FA, MD, and tract volume measures were calculated in patients, based on the corresponding measures obtained from HCs, and then combined in a composite score for each tract. Correlations between Z-scores at baseline and both the Expanded Disability Status Scale (EDSS) at baseline and at follow-up (FU-EDSS) were investigated. Results: Only CST, CC, and OR composite scores as well as the CST volume were significantly associated with FU-EDSS ( p = 0.005, p = 0.007, p = 0.020, and p = 0.010, respectively). Conclusion: The combination of MRI measures rather than the individual metrics better captured the association between tissue damage in both the CC, OR and CST and short-term follow-up disability.
Patient waiting time in the outpatient clinic at a central surgical hospital of Vietnam: Implications for resource allocation
Authors: Tran Tho Dinh , Nguyen Uy Van , Minh Nong Vuong , Tran Bach Xuan 
Published: April 2017

Background: Patient waiting time is considered as a crucial parameter in the assessment of healthcare quality and patients’ satisfaction towards healthcare services. Data concerning this has remained limited in Vietnam. Thus, this study aims to assess patient waiting time in the outpatient clinic in Viet Duc Hospital (Hanoi, Vietnam) in order to enable stakeholders to inform evidence-based interventions to improve the quality of healthcare services. Methods: A cross-sectional study was conducted from June 2014 to June 2015 in the outpatient clinic at Viet Duc Hospital. Waiting time stratified by years (2014 and 2015), months of the year, weekdays, and hours of the day were extracted from Hospital Management software and carefully calculated. Stata 12.0 was employed to analyze data, including the average time (M± SD), frequencies and percentage (%). Results: There was a total of 137,881 patients involved in the study. The average waiting time from registration to preliminary diagnosis in 2014 was 50.41 minutes, and in 2015 was 42.05 minutes. A longer waiting time was recorded in the morning and in those having health insurance. Conclusions: Our study highlights the essential need for human resource promotion to reduce patient waiting time. Also, attention should be paid to the simplification of administrative procedures in order to reduce waiting time among insured patients.