bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dwelling in the Anthropocene: Reimagining University Learning Environments in Response to Social and Ecological Change
Authors: Rousell David 
Published: February 2016

AbstractOver the last three decades, scientists have uncovered the extent of human impacts on the earth's operating systems with increasing clarity and precision. These findings have prompted scientific claims that we have transitioned out of the Holocene and into the Anthropocene epoch in the earth's geological history (Crutzen & Stoermer, 2000). At the same time, the traditional humanist underpinnings of the university have been eroded by the ongoing digitisation, massification, and decentralisation of higher education. This article argues that higher education has a crucial role to play in responding to the Anthropocene thesis, which at the same time provides a powerful impetus for reimagining the university through posthumanist concepts. In developing this analysis, conceptual distinctions are drawn between visions of hope and disaster, the local and the regional, dwelling and construction, and emplacement and displacement in the context of university learning environments. The learning environment is specifically addressed throughout as a fluid and transitional space for experimenting with concepts and practices that operate outside of humanist constructs and disciplinary boundaries. As the very idea of ‘the university campus’ threatens to become an anachronism, the author concludes with a speculative proposition for the reimagining of the university in the Anthropocene era.
The challenges of diagnosis and treatment of dementia in Down’s syndrome
Authors: Vaughan R. M. , McGee C. , Guerin S. , Tyrrell J. , Dodd P. 
Published: February 2016

ObjectivesPeople with Down syndrome (DS) are at high risk for developing dementia and early diagnosis is vital in enhancing quality of life. Our aim was to compare our practice to consensus recommendations on evaluation, diagnosis and pharmacological treatment of individuals with DS who develop dementia. We also aimed to establish the average time taken to make a diagnosis of dementia and to commence pharmacotherapy, and to assess tolerability to acetylcholinesterase inhibitors.MethodsRetrospective chart review in an exhaustive sample containing all current service users attending our service with DS and a diagnosis of dementia (n=20).ResultsThe sample was 75% female and 70% had a moderate intellectual disability. The average age at diagnosis of dementia was 52.42 years old. The average time to diagnosis from first symptom was 1.13 years and the average time to commence pharmacotherapy was 0.23 years. A total of 17 patients commenced on acetylcholinesterase inhibitors, and of these seven discontinued medication due to side-effects or lack of efficacy.ConclusionsThe results on anticholinesterases add to the limited pool of data on treatment of dementia in DS. There was an identified need to improve the rates of medical, vision and hearing assessments, and prospective screening. Deficiencies in screening and diagnosis may be addressed by implementing a standardised dementia assessment pathway to include prospective screening and longitudinal assessment using easily administered scales. We highlight the importance of improving the diagnostic process, as a vital window of opportunity to commence a comprehensive care plan may be lost.
Dynamics of laterally confined marine ice sheets
Authors: Kowal Katarzyna N. , Pegler Samuel S. , Worster M. Grae 
Published: February 2016

We present an experimental and theoretical study of the dynamics of laterally confined marine ice sheets in the natural limit in which the long, narrow channel into which they flow is wider than the depth of the ice. A marine ice sheet comprises a grounded ice sheet in contact with bedrock that floats away from the bedrock at a ‘grounding line’ to form a floating ice shelf. We model the grounded ice sheet as a viscous gravity current resisted dominantly by vertical shear stresses owing to the no-slip boundary condition applied at the bedrock. We model the ice shelf as a floating viscous current resisted dominantly by horizontal shear stresses owing to no-slip boundary conditions applied at the sidewalls of the channel. The two shear-dominated regions are coupled by jump conditions relating force and fluid flux across a short transition region downstream of the grounding line. We find that the influence of the stresses within the transition region becomes negligible at long times and we model the transition region as a singular interface across which the ice thickness and mass flux can be discontinuous. The confined shelf buttresses the sheet, causing the grounding line to advance more than it would otherwise. In the case that the sheet flows on a base of uniform slope, we find asymptotically that the grounding line advances indefinitely as $t^{1/3}$, where $t$ is time. This contrasts with the two-dimensional counterpart, for which the shelf provides no buttressing and the grounding line reaches a steady state (Robison, J. Fluid Mech., vol. 648, 2010, pp. 363–380).
A numerical study of shear layer characteristics of low-speed transverse jets
Authors: Iyer Prahladh S. , Mahesh Krishnan 
Published: February 2016

Direct numerical simulation (DNS) and dynamic mode decomposition (DMD) are used to study the shear layer characteristics of a jet in a crossflow. Experimental observations by Megerian et al. (J. Fluid Mech., vol. 593, 2007, pp. 93–129) at velocity ratios ($R=\overline{v}_{j}/u_{\infty }$) of 2 and 4 and Reynolds number ($Re=\overline{v}_{j}D/{\it\nu}$) of 2000 on the transition from absolute to convective instability of the upstream shear layer are reproduced. Point velocity spectra at different points along the shear layer show excellent agreement with experiments. The same frequency ($St=0.65$) is dominant along the length of the shear layer for $R=2$, whereas the dominant frequencies change along the shear layer for $R=4$. DMD of the full three-dimensional flow field is able to reproduce the dominant frequencies observed from DNS and shows that the shear layer modes are dominant for both the conditions simulated. The spatial modes obtained from DMD are used to study the nature of the shear layer instability. It is found that a counter-current mixing layer is obtained in the upstream shear layer. The corresponding mixing velocity ratio is obtained, and seen to delineate the two regimes of absolute or convective instability. The effect of the nozzle is evaluated by performing simulations without the nozzle while requiring the jet to have the same inlet velocity profile as that obtained at the nozzle exit in the simulations including the nozzle. The shear layer spectra show good agreement with the simulations including the nozzle. The effect of shear layer thickness is studied at a velocity ratio of 2 based on peak and mean jet velocity. The dominant frequencies and spatial shear layer modes from DNS/DMD are significantly altered by the jet exit velocity profile.
Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study
Authors: Soininen Sonja , Eloranta Aino-Maija , Lindi Virpi , Venäläinen Taisa , Zaproudina Nina , Mahonen Anitta , Lakka Timo A. 
Published: February 2016

AbstractWe studied vitamin D intake, serum 25-hydroxyvitamin D (S-25(OH)D) concentration, determinants of S-25(OH)D and risk factors for S-25(OH)D <50 nmol/l in a population sample of Finnish children. We studied 184 girls and 190 boys aged 6–8 years, analysed S-25(OH)D by chemiluminescence immunoassay and assessed diet quality using 4-d food records and other lifestyle factors by questionnaires. We analysed the determinants of S-25(OH)D using linear regression and risk factors for S-25(OH)D <50 nmol/l using logistic regression. Mean dietary intake of vitamin D was 5·9 (sd 2·1) µg/d. Altogether, 40·8 % of children used no vitamin D supplements. Of all children, 82·4 % did not meet the recommended total vitamin D intake of 10 µg/d. Milk fortified with vitamin D was the main dietary source of vitamin D, providing 48·7 % of daily intake. S-25(OH)D was <50 nmol/l in 19·5 % of children. Consumption of milk products was the main determinant of S-25(OH)D in all children (standardised regression coefficient β=0·262; P<0·001), girls (β=0·214; P=0·009) and boys (β=0·257; P=0·003) in multivariable models. Vitamin D intake from supplements (β=0·171; P=0·035) and age (β=−0·198; P=0·015) were associated with S-25(OH)D in girls. Children who drank ≥450 g/d of milk, spent ≥2·2 h/d in physical activity, had ≥13·1 h/d of daylight time or were examined in autumn had reduced risk for S-25(OH)D <50 nmol/l. Insufficient vitamin D intake was common among Finnish children, one-fifth of whom had S-25(OH)D <50 nmol/l. More attention should be paid to the sufficient intake of vitamin D from food and supplements, especially among children who do not use fortified milk products.
Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours
Authors: Hosokawa S , Funai K , Sugiyama K , Takahashi G , Okamura J , Takizawa Y , Yamatodani T , Mineta H 
Published: February 2016

AbstractBackground:There is limited information available regarding the benefits and outcomes of resection of pulmonary metastases arising from head and neck cancers.Methods:A retrospective review was performed of 21 patients who underwent resection of pulmonary metastases of primary head and neck malignancies at Hamamatsu University Hospital. Clinical staging, treatment methods, pathological subtype (particularly squamous cell carcinoma), disease-free interval and overall survival were evaluated.Results:The 5- and 10-year overall survival rates of the study participants were 67.0 per cent and 55.0 per cent, respectively, as determined by the Kaplan–Meier method. The prognosis for patients with a disease-free interval of less than 24 months was poor compared to those with a disease-free interval of greater than 24 months (p = 0.0234).Conclusion:Patients with short disease-free intervals, and possibly those who are older than 60 years, should be categorised as having severe disease. However, pulmonary metastases from head and neck malignancies are potentially curable by surgical resection.
(Un)separated by a common language?
Authors: Murphy M. Lynne 
Published: February 2016

Interest in the differences between English in Britain (or more especially England) and the United States supports a small industry, of which I am a small part. But there are those who argue that the differences are so negligible that they are not worth investigating. One of these is University of Edinburgh Professor of General Linguistics Geoffrey Pullum, who wrote a post on the topic for the Lingua Franca blog of the Chronicle of Higher Education. Pullum (2014) concluded:
Looked at seriously, the tiny differences between standard American and standard British English are trivial, barely even worth mentioning.
Pullum was motivated to make this argument for good reasons. He was fighting the exaggeration of the differences and pointing out that Britons and Americans generally understand each other well in spite of whatever differences there are. But at the same time, Pullum's argument rests on oversimplifications, just like the claims that he hopes to counter.
Seroprevalence of West Nile and Usutu viruses in military working horses and dogs, Morocco, 2012: dog as an alternative WNV sentinel species?
Authors: DURAND B. , HASKOURI H. , LOWENSKI S. , VACHIERY N. , BECK C. , LECOLLINET S. 
Published: February 2016

SUMMARYA serosurvey of 349 military working horses and 231 military working dogs was conducted in ten sites in Morocco in 2012. This survey revealed a high level of exposure of these animals to flaviviruses: seroprevalence rates of 60% in horses and of 62% in dogs were observed using a competitive West Nile virus (WNV) enzyme-linked immunosorbent assay (cELISA). Seroneutralization test results showed that the majority of cELISA-positive results were due to exposure to WNV. Further assays conducted in vaccinated horses with a DIVA (Differentiating Infected from Vaccinated Animals) test indicated that anti-WNV antibodies had been stimulated through WNV natural infection. Moreover, in both species, seroneutralization tests suggested an exposure to Usutu virus (USUV). Data analysis did not show any significant difference of cELISA seropositivity risk between horses and dogs. Dogs may thus represent an interesting alternative to equines for the serological surveillance of WNV or USUV circulation, especially in areas where equine vaccination precludes passive surveillance (based on the detection of West Nile fever cases) in horses.
Description of Medication Administration by Emergency Medical Services during Mass-casualty Incidents in the United States
Authors: El Sayed Mazen , Tamim Hani , Mann N. Clay 
Published: February 2016

AbstractBackgroundEmergency Medical Services (EMS) preparedness and availability of essential medications are important to reduce morbidity and mortality from mass-casualty incidents (MCIs).ObjectivesThis study describes prehospital medication administration during MCIs by different EMS service levels.MethodsThe US National EMS Public-Release Research Dataset maintained by the National Emergency Medical Services Information System (NEMSIS) was used to carry out the study. Emergency Medical Services activations coded as MCI at dispatch, or by EMS personnel, were included. The Center for Medicare and Medicaid Services (CMS) service level was used for the level of service provided. A descriptive analysis of medication administration by EMS service level was carried out.ResultsAmong the 19,831,189 EMS activations, 53,334 activations had an MCI code, of which 26,110 activations were included. There were 8,179 (31.3%) Advanced Life Support (ALS), 5,811 (22.3%) Basic Life Support (BLS), 399 (1.5%) Air Medical Transport (AMT; fixed or rotary), and 38 (0.2%) Specialty Care Transport (SCT) activations. More than 80 different medications from 18 groups were reported. Seven thousand twenty-one activations (26.9%) had at least one medication administered. Oxygen was most common (16.3%), followed by crystalloids (6.9%), unknown (5.2%), analgesics (3.2%) mainly narcotics, antiemetics (1.5%), cardiac/vasopressors/inotropes (0.9%), bronchodilators (0.9%), sedatives (0.8%), and vasodilators/antihypertensives (0.7%). Overall, medication administration rates and frequencies of medications groups significantly varied between EMS service levels (P<.01) except for “Analgesia (other)” (P=.40) and “Pain medications (nonsteroidal anti-inflammatory drug; NSAID)” (P=.07).ConclusionMedications are administered frequently in MCIs, mainly Oxygen, crystalloids, and narcotic pain medications. Emergency Medical Services systems can use the findings of this study to better prepare their stockpiles for MCIs.El SayedM, TamimH, MannNC. Description of medication administration by Emergency Medical Services during mass-casualty incidents in the United States. Prehosp Disaster Med. 2016;31(2):141–149.
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
Authors: Hartmann Petra , Zhou Zhe , Natarelli Lucia , Wei Yuanyuan , Nazari-Jahantigh Maliheh , Zhu Mengyu , Grommes Jochen , Steffens Sabine , Weber Christian , Schober Andreas 
Published: February 2016

AbstractMicroRNAs regulate the maladaptation of endothelial cells (ECs) to naturally occurring disturbed blood flow at arterial bifurcations resulting in arterial inflammation and atherosclerosis in response to hyperlipidemic stress. Here, we show that reduced endothelial expression of the RNAse Dicer, which generates almost all mature miRNAs, decreases monocyte adhesion, endothelial C–X–C motif chemokine 1 (CXCL1) expression, atherosclerosis and the lesional macrophage content in apolipoprotein E knockout mice (Apoe−/−) after exposure to a high-fat diet. Endothelial Dicer deficiency reduces the expression of unstable miRNAs, such as miR-103, and promotes Krüppel-like factor 4 (KLF4)-dependent gene expression in murine atherosclerotic arteries. MiR-103 mediated suppression of KLF4 increases monocyte adhesion to ECs by enhancing nuclear factor-κB-dependent CXCL1 expression. Inhibiting the interaction between miR-103 and KLF4 reduces atherosclerosis, lesional macrophage accumulation and endothelial CXCL1 expression. Overall, our study suggests that Dicer promotes endothelial maladaptation and atherosclerosis in part by miR-103-mediated suppression of KLF4.
A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae
Authors: Pernice Wolfgang M. , Vevea Jason D. , Pon Liza A. 
Published: February 2016

AbstractPrevious studies indicate that replicative lifespan in daughter cells of Sacchraromyces cerevisiae depends on the preferential inheritance of young, high-functioning mitochondria. We report here that mitochondria are functionally segregated even within single mother cells in S. cerevisiae. A high-functioning population of mitochondria accumulates at the tip of the mother cell distal to the bud. We find that the mitochondrial F-box protein (Mfb1p) localizes to mitochondria in the mother tip and is required for mitochondrial anchorage at that site, independent of the previously identified anchorage protein Num1p. Deletion of MFB1 results in loss of the mother-tip-localized mitochondrial population, defects in mitochondrial function and premature replicative ageing. Inhibiting mitochondrial inheritance to buds, by deletion of MMR1, in mfb1Δ cells restores mitochondrial distribution, promotes mitochondrial function and extends replicative lifespan. Our results identify a mechanism that retains a reservoir of high-functioning mitochondria in mother cells and thereby preserves maternal reproductive capacity.
Intracellular mGluR5 plays a critical role in neuropathic pain
Authors: Vincent Kathleen , Cornea Virginia M. , Jong Yuh-Jiin I. , Laferrière André , Kumar Naresh , Mickeviciute Aiste , Fung Jollee S. T. , Bandegi Pouya , Ribeiro-da-Silva Alfredo , O’Malley Karen L. , Coderre Terence J. 
Published: February 2016

AbstractSpinal mGluR5 is a key mediator of neuroplasticity underlying persistent pain. Although brain mGluR5 is localized on cell surface and intracellular membranes, neither the presence nor physiological role of spinal intracellular mGluR5 is established. Here we show that in spinal dorsal horn neurons >80% of mGluR5 is intracellular, of which ∼60% is located on nuclear membranes, where activation leads to sustained Ca2+responses. Nerve injury inducing nociceptive hypersensitivity also increases the expression of nuclear mGluR5 and receptor-mediated phosphorylated-ERK1/2, Arc/Arg3.1 and c-fos. Spinal blockade of intracellular mGluR5 reduces neuropathic pain behaviours and signalling molecules, whereas blockade of cell-surface mGluR5 has little effect. Decreasing intracellular glutamate via blocking EAAT-3, mimics the effects of intracellular mGluR5 antagonism. These findings show a direct link between an intracellular GPCR and behavioural expressionin vivo. Blockade of intracellular mGluR5 represents a new strategy for the development of effective therapies for persistent pain.
Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease
Authors: Borchert Robin J , Rittman Timothy , Passamonti Luca , Ye Zheng , Sami Saber , Jones Simon P , Nombela Cristina , Vázquez Rodríguez Patricia , Vatansever Deniz , Rae Charlotte L , Hughes Laura E , Robbins Trevor W , Rowe James B 
Published: February 2016

AbstractCognitive impairment is common in Parkinson’s disease (PD), but often not improved by dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits are therefore of growing interest. Imaging the brain at rest (‘task-free’) provides the opportunity to examine the impact of a candidate drug on many of the brain networks that underpin cognition, while minimizing task-related performance confounds. We test this approach using atomoxetine, a selective noradrenaline reuptake inhibitor that modulates the prefrontal cortical activity and can facilitate some executive functions and response inhibition. Thirty-three patients with idiopathic PD underwent task-free fMRI. Patients were scanned twice in a double-blind, placebo-controlled crossover design, following either placebo or 40-mg oral atomoxetine. Seventy-six controls were scanned once without medication to provide normative data. Seed-based correlation analyses were used to measure changes in functional connectivity, with the right inferior frontal gyrus (IFG) a critical region for executive function. Patients on placebo had reduced connectivity relative to controls from right IFG to dorsal anterior cingulate cortex and to left IFG and dorsolateral prefrontal cortex. Atomoxetine increased connectivity from the right IFG to the dorsal anterior cingulate. In addition, the atomoxetine-induced change in connectivity from right IFG to dorsolateral prefrontal cortex was proportional to the change in verbal fluency, a simple index of executive function. The results support the hypothesis that atomoxetine may restore prefrontal networks related to executive functions. We suggest that task-free imaging can support translational pharmacological studies of new drug therapies and provide evidence for engagement of the relevant neurocognitive systems.
Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia
Authors: Dhawan Andrew , Madani Tonekaboni Seyed Ali , Taube Joseph H. , Hu Stephen , Sphyris Nathalie , Mani Sendurai A. , Kohandel Mohammad 
Published: February 2016

AbstractHypoxia, or oxygen deficiency, is known to be associated with breast tumour progression, resistance to conventional therapies and poor clinical prognosis. The epithelial-mesenchymal transition (EMT) is a process that confers invasive and migratory capabilities as well as stem cell properties to carcinoma cells thus promoting metastatic progression. In this work, we examined the impact of hypoxia on EMT-associated cancer stem cell (CSC) properties, by culturing transformed human mammary epithelial cells under normoxic and hypoxic conditions and applying in silico mathematical modelling to simulate the impact of hypoxia on the acquisition of CSC attributes and the transitions between differentiated and stem-like states. Our results indicate that both the heterogeneity and the plasticity of the transformed cell population are enhanced by exposure to hypoxia, resulting in a shift towards a more stem-like population with increased EMT features. Our findings are further reinforced by gene expression analyses demonstrating the upregulation of EMT-related genes, as well as genes associated with therapy resistance, in hypoxic cells compared to normoxic counterparts. In conclusion, we demonstrate that mathematical modelling can be used to simulate the role of hypoxia as a key contributor to the plasticity and heterogeneity of transformed human mammary epithelial cells.