bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing MJO Intensity over the Tropical Western Pacific during Mega and Equatorial La Niña Winters
Authors: Cao Can , Wu Zhiwei 
Published: September 2024

Abstract
This study investigated variations in the Madden–Julian oscillation (MJO) behavior between two types of La Niña winters: mega and equatorial La Niñas. Results of this work show that in contrast to mega conditions, accompanied by more abundant intraseasonal column-integrated moisture anomalies over the planetary boundary layer, intensities of intraseasonal outgoing longwave radiation anomalies are stronger over the tropical western Pacific (WP) at MJO phases 5–6 under equatorial conditions. The occurrence of the moisture anomaly change averaged over the tropical WP is supported by a distinct moisture tendency difference. Moisture budget and multiscale interaction diagnoses underscore the pivotal effect of an area-averaged vertical gradient change in low-frequency background moisture in driving such tendency change. Considering notable MJO convection variations, the teleconnections associated with MJO phases 5–6 over East Asia (EA) were also explored, including warmer surface air temperature anomalies and stronger positive geopotential height anomalies at 200 hPa on the intraseasonal time scale under equatorial conditions. Results from a linear baroclinic model demonstrate that such teleconnection changes could be effectively explained by the linear response to the MJO’s diabatic heating anomaly. Roles of mean state and MJO itself variations in the linear response change are also discussed. These findings provide novel insights into MJO activity and offer potential improvements for subseasonal forecasting in EA.
Significance Statement
The relationship between El Niño–Southern Oscillation (ENSO) and MJO has been extensively explored recently. However, variations in the MJO behavior and its climate effects under mega and equatorial La Niña winters have not been thoroughly investigated. In this work, we utilized reanalysis datasets and an idealized linear baroclinic model to address these questions. We observed more robust and abundant intraseasonal convection activity and planetary boundary layer–integrated moisture anomaly averaged over the tropical WP at MJO phases 5–6 under equatorial conditions than mega conditions, which is closely linked with the vertical gradient change in low-frequency background moisture. Additionally, MJO-related teleconnections also exhibit some changes. This work may provide a new perspective on understanding the relationship between the MJO and ENSO and offer potential improvements for the subseasonal forecast.
Project Impact: A Public Community College Campus–Based Support and Reentry Program for Justice-Impacted Students in New York City
Authors: Ronda Michelle , Rose Lisa Hale 
Published: September 2024

Background: Between 70 million and 100 million Americans have a record of interaction with the criminal legal system, a group facing stigma and discrimination in civic participation, housing, employment, and education. Justice-impacted people face collateral consequences in the community, making reentry programs essential to success at reintegration. Focus of Study: Project Impact (PI) at the Borough of Manhattan Community College/City University of New York (BMCC/CUNY) supports students impacted by the criminal legal system. PI provides direct services to justice-impacted students through an extensive peer mentoring program and a high school equivalency program, and by offering college credit–bearing courses to students presently incarcerated in partnership with John Jay College’s Prison-to-College Pipeline. PI defines “justice impacted” expansively as students who have been formerly incarcerated, have family who have been incarcerated or arrested, have had issues in family court, or in any other way have been significantly affected by the criminal legal system. Research Design/Conclusions: This evaluation provides unequivocal evidence of the strong, positive impact that PI is making, serving as a rare campus-based reentry program within a community college in New York City.
“A Change Is Gonna Come”: Pedagogical Shifts in a Post-COVID World
Authors: Yee Sharon 
Published: September 2024

Background/Context: COVID-19 changed how students learn, the challenges they face both in and out of the classroom, and the ways they access and engage with higher education. COVID-19 also highlighted inequalities in higher education. In response, faculty have also had to change their pedagogical approaches. Purpose/Focus of Study: This article presents ideas to address some of the challenges that COVID-19 has brought to the community college classroom. The focus of these strategies and pedagogical changes is to create a more equitable and successful environment for all students. Research Design: The author’s praxis used Paulo Freire’s 1970 work, The Pedagogy of the Oppressed, as a guide to critically examine pedagogical practices and choices for sociological curriculum development at a medium-sized, urban, Hispanic-serving community college. Changes were evaluated through final grade analysis and student feedback. Findings: Ten changes were implemented: making the course mobile phone/tablet accessible, incorporating audio transcripts for all, using additional video formats, engaging families/children, addressing student anxieties, incorporating more assignment choices, using Open Educational Resources for reduced costs, allowing more flexibility in assignments, extending submission times, and varying course length. These changes have reduced barriers, decreased student anxiety, and increased student success. Conclusions: The pedagogical changes made seemed to help students be more successful in their courses.
Pedagogical and Institutional Responses to Student Precarity Illuminated by COVID-19
Authors: Isserles Robin G. , Huang Paoyi 
Published: September 2024

Purpose, Objective, Research Question, or Focus of Study: This paper seeks to understand the withdrawal patterns of students enrolled in an urban community college during the COVID-19 outbreak, by focusing on what students voiced about what made college-going so challenging for them from spring 2020 to fall 2021. What was revealed about their decisions to withdraw offers some important considerations for those who work with first-generation, economically and academically fragile college students throughout the higher education landscape. To contextualize our findings, we draw on some of the writings of educators who have shaped our own pedagogical practices. Research Design: We interviewed 14 students on Zoom—some in small focus groups and others one-on-one—who had withdrawn from at least one course up to an entire semester. Conclusions or Recommendations: Our findings suggest that we take stock of the pre-existing precarities of many students that have been illuminated, carefully balancing what students have voiced about what they need with the very real structural constraints that make “good teaching” difficult to sustain. A salient theme, one that we had not expected, is what students expressed about what good teaching is to them and how much it mattered. This raises not only important pedagogical questions but also structural ones. How do our institutions create the conditions (or not) for good teaching, as defined by students?
Adolescent mindfulness may buffer the longitudinal effect of parental work-family conflict and interparental conflict on adolescent affiliation with deviant peers
Authors: Wang Mingzhong , Wang Jing 
Published: September 2024

Parental work-family conflict undermines family functioning, which in turn may impair children’s peer functioning. Using a longitudinal design spanning across 2 years, the present study examined whether paternal/maternal work-family conflict could predict interparental conflict and, in turn, whether such conflict contributed to adolescent affiliation with deviant peers. Additionally, this study also explored the moderating role of adolescent mindfulness on these relationships. As part of a large longitudinal project, 1427 adolescents (773 boys and 654 girls; aged from 12 to 15 years, M = 12.66 years, SD = 0.63) completed questionnaires regarding perceived interparental conflict, deviant peer affiliation, and mindfulness, and both parents reported on questionnaires regarding their own work-family conflict at three-time points with 1-year intervals. Results indicated that paternal but not maternal work-family conflict positively predicted interparental conflict, which was further positively predictive of deviant peer affiliation for adolescents with low but not high mindfulness. Our study revealed the role of paternal work-family conflict as a seemingly distal but relatively proximal risk factor for adolescents’ affiliation with deviant peers, as well as the buffering role of mindfulness on the longitudinal relations.
Less is more? A review of psilocybin microdosing
Authors: Savides Isabella A , Outhoff Kim 
Published: September 2024

Background: The applications of psilocybin, derived from ‘magic mushrooms,’ are vast, including a burgeoning practice known as microdosing, which refers to the administration of sub-hallucinogenic doses of psychedelic substances to obtain benefits without experiencing significant cognitive and perceptual distortion. However, current research is fairly new with several limitations and gaps that hinder adequate conclusions on its efficacy. Aims: This semi-structured review aimed to identify and highlight research gaps in the field of psilocybin microdosing for future research. Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses based strategy was employed, utilizing a chain of keywords and key phrases across multiple databases, augmented by a cross-sectional Google search for relevant grey literature in the form of the top 10 search results. A total of 40 studies and 8 unique websites were identified, summarized and tabulated into four distinct categories, namely non-clinical, clinical, observational and anecdotal evidence. Results: The majority of available evidence originates from observational studies, while non-clinical and clinical study findings remain comparatively sparse and inconsistent. Web-based findings were consistent with current research findings. Key research gaps were highlighted: the imperative for more randomized placebo-controlled trials, exploration of dose-response ranges, psychological and personality testing of participants, utilization of active placebos, greater diversity in study populations, an increase in psilocybin-exclusive microdosing studies and the refinement of animal models. Conclusion: Definitive conclusions regarding the efficacy of psilocybin microdosing remain elusive, emphasizing the need for further study. Numerous research gaps necessitate consideration for future investigations.
Pulmonary nodule visualization and evaluation of AI-based detection at various ultra-low-dose levels using photon-counting detector CT
Authors: Jungblut Lisa , Euler André , Landsmann Anna , Englmaier Vanessa , Mergen Victor , Sefirovic Medina , Frauenfelder Thomas 
Published: September 2024

Background Radiation dose should be as low as reasonably achievable. With the invention of photon-counting detector computed tomography (PCD-CT), the radiation dose may be considerably reduced. Purpose To evaluate the potential of PCD-CT for dose reduction in pulmonary nodule visualization for human readers as well as for computer-aided detection (CAD) studies. Material and Methods A chest phantom containing pulmonary nodules of different sizes/densities (range 3–12 mm and −800–100 HU) was scanned on a PCD-CT with standard low-dose protocol as well as with half, quarter, and 1/40 dose (CTDIvol 0.4–0.03 mGy). Dose-matched scans were performed on a third-generation energy-integrating detector CT (EID-CT). Evaluation of nodule visualization and detectability was performed by two blinded radiologists. Subjective image quality was rated on a 5-point Likert scale. Artificial intelligence (AI)-based nodule detection was performed using commercially available software. Results Highest image noise was found at the lowest dose setting of 1/40 radiation dose (eff. dose = 0.01mSv) with 166.1 ± 18.5 HU for PCD-CT and 351.8 ± 53.0 HU for EID-CT. Overall sensitivity was 100% versus 93% at standard low-dose protocol (eff. dose = 0.2 mSv) for PCD-CT and EID-CT, respectively. At the half radiation dose, sensitivity remained 100% for human reader and CAD studies in PCD-CT. At the quarter radiation dose, PCD-CT achieved the same results as EID-CT at the standard radiation dose setting (93%, P = 1.00) in human reading studies. The AI-CAD system delivered a sensitivity of 93% at the lowest radiation dose level in PCD-CT. Conclusion At half dose, PCD CT showed pulmonary nodules similar to full-dose PCD, and at quarter dose, PCD CT performed comparably to standard low-dose EID CT. The CAD algorithm is effective even at ultra-low doses.
Arthroscopic Centralization of the Medial Meniscus Reduces Load on a Posterior Root Repair Under Dynamic Varus Loading: A Biomechanical Investigation
Authors: Deichsel Adrian , Peez Christian , Raschke Michael J. , Richards R. Geoff , Gueorguiev Boyko , Zderic Ivan , Herbst Elmar , Kittl Christoph 
Published: September 2024

Background: In addition to the integrity of the meniscal hoop function, both the anterior and posterior meniscus roots as well as the meniscotibial and meniscofemoral ligaments are crucial in restraining meniscal extrusion. However, the interaction and load sharing between the roots and these peripheral attachments (PAs) are not known. Purposes: To investigate the influence of an insufficiency of the PAs on the forces acting on a posterior medial meniscus root repair (PMMRR) in both neutral and varus alignment and to explore whether meniscal centralization reduces these forces. Study Design: Controlled laboratory study. Methods: In 8 fresh-frozen human cadaveric knees, an arthroscopic transosseous root repair (step 1) was performed after sectioning the posterior root of the medial meniscus. The pull-out suture was connected to a load cell to allow measurement of the forces acting on the root repair. A medial closing-wedge distal femoral osteotomy was performed to change the mechanical axis from neutral to 5° of varus alignment. The meniscus was completely released from its PAs (step 2), followed by transosseous arthroscopic centralization (step 3). Each step was tested in both neutral and varus alignment. The specimens were subjected to nondestructive dynamic varus loading under axial compression of 300 N in 0°, 15°, 30°, 45°, and 60° flexion. The changes in force acting on the PMMRR were statistically analyzed using a mixed linear model. Results: Axial loading in neutral alignment led to an increase of the force of root repair of 3.1 ± 3.1 N (in 0° flexion) to 6.3 ± 4.4 N (in 60° flexion). In varus alignment, forces increased significantly from 30° (3.5 N; 95% CI, 1.1-5.8 N; P = .01) to 60° (7.1 N; 95% CI, 2.7-11.5 N; P = .007) flexion, in comparison with neutral alignment. Cutting of the PAs in neutral alignment led to a significant increase of root repair forces in all flexion angles, from 7.0 N (95% CI, 1.0-13.0 N; P = .02) to 9.1 N (95% CI, 4.1-14.1 N; P = .003), in comparison with the intact state. Varus alignment significantly increased the forces in the cut states from 4.8 N (95% CI, 1.0-8.5 N; P = .02) to 11.1 N (95% CI, 4.2-18.0 N; P = .006) from 30° to 60° flexion, in comparison with the neutral alignment. Arthroscopic centralization led to restoration of the native forces in both neutral and varus alignment, with no significant differences between the centralized and intact states. Conclusion: An insufficiency of the PAs of the medial meniscus, as well as varus alignment, led to increased forces acting on a PMMRR. These forces were reduced via an arthroscopic meniscal centralization. Clinical Relevance: Performing arthroscopic meniscal centralization concomitantly with PMMRR may reduce failure of the repair by reducing the load of the root.
Acute Changes in Liver Function Tests During Initiation of Ketogenic Diet
Authors: Katyayan Akshat , Nayak Anuranjita , Diaz-Medina Gloria , Handoko Maureen , Riviello James John 
Published: September 2024

Background Ketogenic diet is an effective therapy for patients with medically refractory epilepsy. It is generally well tolerated, with the most common side effects being gastrointestinal. Hepatic toxicity has been described as an uncommon side effect of ketogenic diet, usually with long-term use. However, there are limited data to implicate ketogenic diet in acute liver toxicity. Methods and results We analyzed all patients who underwent elective inpatient ketogenic diet initiation at our institution from June 2019 to June 2022. Of the 25 patients reviewed, we found 6 patients who showed acute, asymptomatic changes in liver function tests during initiation, in both hepatocellular and cholestatic patterns. Two patients stopped the ketogenic diet acutely and 3 patients continued ketogenic diet with changes in medications and/or addition of choline—all patients had improvement and normalization of liver function tests in the short term. One patient had acute normalization of chronically elevated liver function tests on ketogenic diet initiation. Conclusion Ketogenic diet can cause acute changes in liver function tests during initiation of ketogenic diet, with both hepatocellular and cholestatic patterns, with and without the concurrent use of hepatotoxic medications. In most patients, ketogenic diet can be continued successfully by making changes to medications or addition of choline.
Associations Between Weight Perception and Weight Status With Perceptions of the Body Positivity Movement
Authors: Rupp Kristie , McCoy Stephanie M. 
Published: September 2024

Purpose To explore the relationships between weight status, weight perceptions, and perceptions of the body positivity movement on social media. Design Cross-sectional. Setting Online through the Qualtrics platform. Subjects Participants (N = 521; mean 26.6 ± 5.1 years) were recruited using Qualtrics online panels. Measures The study survey included questions about participant demographics, weight status, and weight perception. Subjects rated 6 study-specific viewpoint questions about the body positivity movement on a 5pt Likert scale. Analysis Multinomial logistic regression models adjusted for relevant confounders assessed the associations between objective weight status, perceived weight status, and perceptions of the body positivity movement. Results Objective weight status was not associated with perceptions of the body positivity movement. Perceptions of weight status were associated with perceptions of the body positivity movement in young women, with those that perceived themselves as overweight more likely (OR = 1.67, P < 0.05) to disagree with the statement that “the body positivity makes people less likely to lose weight.”. However, young women that perceived themselves as having a lower weight status were less likely (OR = 0.54, P < 0.05) to agree with the statement that “the body positivity movement empowered women” as well as “being inclusive of people of all sizes” (OR = 0.56, P < 0.05). Conclusion Weight perception, rather than objective weight status, may be a stronger predictor of weight bias and views of the body positivity movement.
Genetic susceptibility and clinical features of CYP2D6 associated with systemic lupus erythematosus in a Chinese population
Authors: Luo Xiaoning , Du Juanhua , Zhao Jinjun , Fan Meida , Luo Xin , Zhao Peijin , Zheng Ping , Mo Liqian , Li Yilei 
Published: September 2024

Objective This study aims to explore possible susceptibility genes and clinical features for systemic lupus erythematosus (SLE) patients in a Chinese population. Methods Expanding on the results of a prior single-center observational study involving 60 systemic lupus erythematosus patients, a subsequent single-center prospective observational study was conducted on SLE patients undergoing treatment at Nanfang Hospital Affiliated to Southern Medical University from 2021 to 2023. The identification process for drug-related target genes entailed an extensive search across PharmGKB ( https://www.pharmgkb.org/ ), the Clinical Pharmacogenetics Implementation Consortium (CPIC),and PubMed literature databases, to pinpoint common drugs and target single nucleotide polymorphisms(SNPs)for SLE. Blood samples were individually collected and genotyped using MassARRAY® high-throughput nucleic acid mass spectrometry. Genotype frequency differences were assessed through Chi-square tests against both the larger East Asian population as well as kidney transplant recipients. Data collection relied on electronic medical records, encompassing demographic details(age, gender),medication regimens(hormones, NSAIDs, hydroxychloroquine, DMARDs, biologic agents, stomach medications, calcitriol, etc.),laboratory indicators(RF, Anti-CCP antibody, ESR, CRP, anti-ANA antibodies, dsDNA antibodies, anti-SM antibodies, S m. RNP antibodies, A LT, ALB, CR, UA, WBC, PLT, HGB, Ca, K, Glu, CHOL, TG, LDL-C, HDL-C) and lupus activity scores(SLEDAI-2K). Possible disease susceptibility genes were categorized, and SPSS26 software facilitated statistical analyses. Results The research encompassed a total of 137 SLE patients along with 50 SNPs. After conducting statistical analyses, it emerged that there existed significant disparities in CYP2D6 gene (rs1065852) distribution when compared against allele mutation rates within both East Asian populations ( p < .05) and kidney transplant patients( p < .05). Wild-type gene (GG) constituted 14% of cases while mutant gene (GA + AA) constituted 86%. Allele mutation rate (A63.6%) was significantly higher among SLE patients (RR = 0.802; p = .0355). Furthermore, the variant rs1065852 genotype (GA + AA) demonstrated significant associations with lower CRP levels, higher HGB levels, and higher HDL-C levels ( p < 0 0.05). Conclusion The metabolic enzyme CYP2D6 may be used as susceptibility gene for predicting systemic lupus erythematosus and are correlated with CRP and other indicators.
Impact of Acquired Brain Injury on Quality of Life
Authors: Dua Sharad , Kumar Rita , Prasannanshu  , Narang Karanjit Singh 
Published: September 2024

Background An injury to the brain affects a person in some or all cognitive, emotional, behavioural and physical domains impacting quality of life. Quality of life is essential to well-being and optimum functioning of a person in daily life. It is influenced by various individual and social aspects like physical, psychological, social relationships and environment. This article discusses an overview of impact of acquired brain injury on quality of life. Purpose This article aims to create an awareness of the nature of brain injury, factors impacting quality of life, and inter-relationships amongst them which can have implications for clinical rehabilitation. Conclusion An acquired brain injury is a life-changing event for the affected person and the family. It is globally considered a national burden. As compared to the developed countries, the availability and access to social determinants of health is low in the underdeveloped, and developing countries. An awareness of the nature of brain injury, the prognosis, available approaches to treatment can enable simple cost-effective psychosocial interventions to complement overall rehabilitation plan.