bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 3D supramolecular architecture based on 2,2′-oxybis(benzoic acid) and trans-1,2-bis(4-pyridyl)ethylene as ligands for Co(II)
Authors: Tang Long , Zhang Juan , Liu Xiao-Xia , Wang Ji-Jiang , Fu Feng 
Published: May 2017

Abstract
The reaction of CoCl2·6H2O with mixed ligands of 2,2′-oxybis(benzoic acid) (2,2′-H2oba) and trans-1,2-bis(4-pyridyl)ethylene (bpe) under hydrothermal conditions produced a new 3D cobalt(II) supramolecular architecture {[Co(oba)(bpe)(H2O)]·1/2bpe}
n
(1), which was structurally characterized by elemental analysis, infrared spectroscopy, thermogravimetric analyses, and single-crystal X-ray diffraction. The results show that the Co(II) ions are connected to form an infinite polymeric chain by bpe ligands in complex 1. Due to strong intermolecular O–H···O hydrogen bonds, the adjacent chains are connected to generate a double-chain structure. These double chains are joined by O–H···N hydrogen bonding to produce a 2D supramolecular architecture. Furthermore, through intermolecular C–H···O hydrogen bonds, the layers are linked into a 3D supramolecular structure. Magnetic susceptibility measurements have indicated that complex 1 shows weak antiferromagnetic interactions between adjacent Co(II) ions.
c‐MYC mRNA tail tale about glutamine control of transcription
Authors: Dang Chi V 
Published: May 2017

Dejure et al (2017) demonstrates an intriguing link between glutamine, c‐MYC protein levels, and c‐MYC‐dependent transcription. Glutamine‐dependent c‐MYC protein level, which is sensed through the c‐MYC mRNA 3′‐UTR, determines global transcriptional response to glutamine deprivation in HCT116 colon cancer cells. These findings add another layer of complexity to c‐MYC's role as a nexus in metabolic regulation.
Ca2+ binding to F‐ATP synthase β subunit triggers the mitochondrial permeability transition
Authors: Giorgio Valentina , Burchell Victoria , Schiavone Marco , Bassot Claudio , Minervini Giovanni , Petronilli Valeria , Argenton Francesco , Forte Michael , Tosatto Silvio , Lippe Giovanna , Bernardi Paolo 
Published: May 2017

AbstractF‐ATP synthases convert the electrochemical energy of the H+ gradient into the chemical energy of ATP with remarkable efficiency. Mitochondrial F‐ATP synthases can also undergo a Ca2+‐dependent transformation to form channels with properties matching those of the permeability transition pore (PTP), a key player in cell death. The Ca2+ binding site and the mechanism(s) through which Ca2+ can transform the energy‐conserving enzyme into a dissipative structure promoting cell death remain unknown. Through in vitro, in vivo and in silico studies we (i) pinpoint the “Ca2+‐trigger site” of the PTP to the catalytic site of the F‐ATP synthase β subunit and (ii) define a conformational change that propagates from the catalytic site through OSCP and the lateral stalk to the inner membrane. T163S mutants of the β subunit, which show a selective decrease in Ca2+‐ATP hydrolysis, confer resistance to Ca2+‐induced, PTP‐dependent death in cells and developing zebrafish embryos. These findings are a major advance in the molecular definition of the transition of F‐ATP synthase to a channel and of its role in cell death.
Lipophagy prevents activity‐dependent neurodegeneration due to dihydroceramide accumulation in vivo
Authors: Jung Wei‐Hung , Liu Chung‐Chih , Yu Yu‐Lian , Chang Yu‐Chin , Lien Wen‐Yu , Chao Hsi‐Chun , Huang Shu‐Yi , Kuo Ching‐Hua , Ho Han‐Chen , Chan Chih‐Chiang 
Published: May 2017

AbstractDihydroceramide desaturases are evolutionarily conserved enzymes that convert dihydroceramide (dhCer) to ceramide (Cer). While elevated Cer levels cause neurodegenerative diseases, the neuronal activity of its direct precursor, dhCer, remains unclear. We show that knockout of the fly dhCer desaturase gene, infertile crescent (ifc), results in larval lethality with increased dhCer and decreased Cer levels. Light stimulation leads to ROS increase and apoptotic cell death in ifc‐KO photoreceptors, resulting in activity‐dependent neurodegeneration. Lipid‐containing Atg8/LC3‐positive puncta accumulate in ifc‐KO photoreceptors, suggesting lipophagy activation. Further enhancing lipophagy reduces lipid droplet accumulation and rescues ifc‐KO defects, indicating that lipophagy plays a protective role. Reducing dhCer synthesis prevents photoreceptor degeneration and rescues ifc‐KO lethality, while supplementing downstream sphingolipids does not. These results pinpoint that dhCer accumulation is responsible for ifc‐KO defects. Human dhCer desaturase rescues ifc‐KO larval lethality, and rapamycin reverses defects caused by dhCer accumulation in human neuroblastoma cells, suggesting evolutionarily conserved functions. This study demonstrates a novel requirement for dhCer desaturase in neuronal maintenance in vivo and shows that lipophagy activation prevents activity‐dependent degeneration caused by dhCer accumulation.
Pro-IGF2-induced hypoglycaemia associated with hepatocellular carcinoma
Authors: van den Berg S A A , Krol C G 
Published: May 2017

Summary
We present a patient (87 years, female) who was admitted to the emergency department because of loss of consciousness. Previous medical history included advanced-stage hepatocellular carcinoma and associated weight loss. She was found on the ground in an unresponsive state by her daughter and was determined to be hypoglycaemic. Upon bolus administration of 100 mL intravenous glucose (10%), glucose levels increased to 2.9 mmol/L and the patient regained full consciousness. She was admitted to the hospital for further examination, and treatment and continuous intravenous glucose infusion was initiated. As the patient was known to suffer from advanced-stage hepatocellular carcinoma, tumour-associated hypoglycaemia was suspected. Insulin, c-peptide and IGF1 concentrations were indeed low, cortisol concentration was high and IGF2 and Pro-IGF2 were borderline low and borderline high normal respectively. IGF2:IGF1 ratio was 23, confirming the diagnosis of non-islet cell tumour hypoglycaemia. During the initial phase of treatment, euglycaemia was maintained by continuous variable glucose infusion (5%, varying between 1 and 2 L/24 h), and the patient was advised to eat small snacks throughout the day. After euglycaemia was established and the diagnosis was confirmed, prednisolone was started (30 mg, 1 dd) and glucose infusions were halted. Under prednisolone treatment, glucose levels were slightly increased and no further hypoglycaemic episodes occurred. At her request, no surgery was performed. After 19 days, the patient was discharged to a hospice and died 3 weeks later.

Learning points:

Hepatocellular carcinoma may be associated with non-islet cell tumour hypoglycaemia (NICTH).

NICTH-induced hypoglycaemia is associated with low insulin and IGF1.

Measurement of IGF2 only (without measurement of Pro-IGF2 and IGF1) may be insufficient to prove NICTH.
The Problem of the Values Supporting Reasoning in the Humanities: Cognitive-Pragmatic Approach
Authors: Savtchouk Tatiana 
Published: May 2017

The main cognitive models of the values supporting reasoning in the discourse of the humanities are identified, the typology of selected schemes is made, their modifications are characterised, the pragmatic differences of the models are determined. Particular attention is paid to the “cause to aim” justification of the value judgments that prevails in the humanities. The regularities of verbal representation of cognitive structures are ascertained, pragmatic properties of argumentative markers are explicated. The author’s typology of tactics that implements rational and emotional value-study strategies is proposed. A number of fallacies in the justification of normative value judgments are revealed, such as “semantic-pragmatic dissonance”, “simulation of reasoning”, “pseudoauthority”, “superfluity of argumentative resource”. The sources of such shortcomings are exemplified by the facts from the evidence base. The conclusion is that the author of the article chooses the cognitive model of argumentation in support of the values, the ways of its verbal presentation and the tactics of reasoning on the basis of pragmatic factors.
Linguistic and Extralinguistic Media of Social Representations in the Public Discourse
Authors: Zbróg Zuzanna , Zbróg Piotr 
Published: May 2017

The aim of the article is to present the utility of the social representation theory as a theoretical and methodological basis of the public discourse research. The theory, enunciated by the French psychologist Serge Moscovici, offers a new approach to the research of the way in which the media and communities / social groups construct the understanding of the issues which are important to them. The analysis of public discourse conducted within the framework of this theory is based on the observation of linguistic media with which the processes of anchoring (naming, emotional anchoring, thematic anchoring, anchoring by metaphors, anchoring in antinomies) and objectification (emotional objectification, personification) are conducted. They constitute the basic communicative mechanisms which produce social representations. The role of language as a medium of social representation will be emphasised. The article will also discuss the extralinguistic media of social representations which determine the overall image of discursive social reality. Social representations may be perceived as a tool for description and understanding of reality.
The Sentence as a Functional Genre of Administrative Communication
Authors: Kowalczyk Joanna 
Published: May 2017

This article analyses the function of a sentence as a representative genre of administrative discourse, which has the ability to form and transform legally relevant facts. Functional and pragmatic nature of the sentence, as a document, lies in the ability to mandatory oblige all recipients of the discourse. The aim of the article is to identify the main features and descriptions of the sentence as an administrative discourse genre, which in essence is the main way of interpretation, evaluation and qualification of social behaviour. The study analysis includes the sentence analysis, taking into account three criteria: ontological, causal and pragmatic. This publication also provides a method of qualification of legally relevant facts and the examples of its verbalisation. It is shown that under formal communications, the studied genre of the text is the main instrument of the imperative regulation of social relations. The author indicates that the sentence is a subjective and prescriptive type of administrative document. The sentence is a final explicit act. Fundamental pragmatics of the sentence is focused on identifying and revealing the will of the authorities and influencing the participants of discourse.
Translation Editology: Conceptualising the Unknown Known Interdisciplinary Area of Translation Studies
Authors: Odrekhivska Iryna 
Published: May 2017

The present article is an attempt to examine the status, present the legitimacy and underscore the complexity of the field of ‘translation editology’ within a broad interdisciplinary framework of Translation Studies. This area of translation research is focused on the theoretical and critical reflection on the editorial and publishing practice of translated literature. The overriding objective of the paper is to elaborate an interpretative mechanism of editorial practices in translation and to portray its practical application. Following this line, a three-layer model of translation editorial analysis is suggested. While at the micro-level the functional structural analysis elicits how the text is mediated through specific instances of language use, the meso-level relates to interpersonal dimension centring on translator’s relation to the authorial intentions and the way of their actualisation and concretisation. The macro-level of analysis is discursive, reviews the editor’s “tendentious rewriting” or manipulation of the target text. This model is probed in the analysis of 1983 editorial work performed by Victor Koptilov for the re-publication of 1912 Ukrainian translation of Longfellow’s masterpiece The Song of Hiawatha.
The Eternal Dilemma: to Translate, or not to Translate? Approaches and Positions
Authors: Salmeri Claudio 
Published: May 2017

The phenomenon of translatability is an incredibly interesting translation problem, the subject of eternal disputes and discussions, which probably will never be definitively settled. Translatability is only a theoretical ideal, which, in fact, only corresponds to different degrees of approximation. Untranslatability is caused by the differences in the construction of language systems and the presence of different types of terms, words, common phrases and collocations related to specific socio-cultural phenomena in respective languages. The translatability of statements is also hindered by allusions of language and particular erudite manners of poetic text organisation, used for expressive and aesthetic language-specific sound values and semantic associations. Thus, the translatability of literature, and especially poetry, is particularly limited. The purpose of this article is to debate the problem of (un)translatability and to define its limits. The article is an attempt to discuss the fundamental questions of when the independence and freedom of manoeuvre of a translator reach their limits and whether a text should be translated or left in the original language.
Dimensions of Imagery: Translation Analysis on the Example of “The Lion, The Witch and The Wardrobe”
Authors: Feret Magdalena Zofia Zofia 
Published: May 2017

The aim of this paper is to show how imagery, one of the most important human cognitive abilities, can be expressed. It considers the impact this ability can have on the process of text production and its understanding in translation. The cognitive grammar model by Ronald Wayne Langacker (1987, 1991) has formed the methodological perspective. The application of cognitive translation theory to translation analysis is presented on the example of the novel by Clive Staples Lewis The Lion, the Witch and the Wardrobe and its translation into Polish by Andrzej Polkowski and into German by Lisa Tetzner. First of all, the terms ‘conceptualisation’ and ‘imagery’ are introduced and explained from the cognitive perspective. Then, the dimensions of imagery – selection, abstraction and perspective – are described. Based on this, the examples selected from the novel The Lion, the Witch and the Wardrobe and its Polish and German translations are analysed and the results are discussed.
Proper Names: Translation Analysis on the Example of “Prince Caspian”
Authors: Majcher Agnieszka Elżbieta Elżbieta 
Published: May 2017

The aim of this paper is to present translation strategies applied in the process of literary translation of proper names. The analysis is carried out on the example of the translation of the novel Prince Caspian by Clive Staples Lewis: into Polish by Andrzej Polkowski and into German by Lena Lademann-Wildhagen. The paper analyses how proper names referring to living creatures, geographical or topographical names were translated. The techniques applied by the two translators were significantly different, from transference, substitution, translation of part of the names, through referring associations with the character’s behaviour or the features of the object, to free translation, limited only by the author’s imagination. All the names were analysed in terms of semantics, morphology, for some the graphemes and phonemes were studied. First, the translation techniques used dealing with proper names were identified. Based on this, the results of the analysis of the selected names from the novel and its translations were presented together with conclusions on their influence on the world depicted in the novels and the impact the differences in translations can have on the reader.
Normative Masculinity in the Interwar Lithuanian Press and Advertising: the Image of an Officer
Authors: Bankauskaitė-Sereikienė Gabija , Būblaitytė Inga 
Published: May 2017

The present article is an extended research of the expression of normative masculinity, aiming at complementing the studies on the history of culture and advertising, and the perception of masculinity in the First Independent Republic of Lithuania as well as demonstrating the tendencies of male selfidentification process in the interwar context.
First research results were published in the article “Masculinity Representation in Lithuanian Interwar Press Advertising” (Bankauskaitė, Stravinskaitė 2016). The prevailing images of masculinity were divided into several groups: a heroic superman, a successful careerist, a family man and a hedonistic or narcissistic man. This article complements the normative collection of masculinity with the image traits of an officer. It is the one who, due to the influence of aesthetic standards, fundamental national values active, physical education and aviation achievements, was associated with the highest level of masculinity in the interwar advertising. Active masculine physical power, courage, determination and a wish to dominate, conveyed in the advertisements and articles, are especially important constituent parts of a normative model of masculinity. The model of an officer includes the images of a young, handsome, and educated gentleman who served as a role model for every man in the interwar society.
Sacred Judas and Profane Satan
Authors: Naikienė Ieva 
Published: May 2017

ANDREJEV, L., 2016. Judas Iskarijotas. Šėtono dienoraštis. Iš rusų kalbos vertė Aidas Jurašius. Vilnius: Lietuvos rašytojų sąjungos leidykla. 273 p.
Effectiveness of Tympanostomy Tubes for Otitis Media: A Meta-analysis
Authors: Steele Dale W. , Adam Gaelen P. , Di Mengyang , Halladay Christopher H. , Balk Ethan M. , Trikalinos Thomas A. 
Published: May 2017

CONTEXT:Tympanostomy tube placement is the most common ambulatory surgery performed on children in the United States.OBJECTIVES:The goal of this study was to synthesize evidence for the effectiveness of tympanostomy tubes in children with chronic otitis media with effusion and recurrent acute otitis media.DATA SOURCES:Searches were conducted in Medline, the Cochrane Central Trials Registry and Cochrane Database of Systematic Reviews, Embase, and the Cumulative Index to Nursing and Allied Health Literature.STUDY SELECTION:Abstracts and full-text articles were independently screened by 2 investigators.DATA EXTRACTION:A total of 147 articles were included. When feasible, random effects network meta-analyses were performed.RESULTS:Children with chronic otitis media with effusion treated with tympanostomy tubes compared with watchful waiting had a net decrease in mean hearing threshold of 9.1 dB (95% credible interval: −14.0 to −3.4) at 1 to 3 months and 0.0 (95% credible interval: −4.0 to 3.4) by 12 to 24 months. Children with recurrent acute otitis media may have fewer episodes after placement of tympanostomy tubes. Associated adverse events are poorly defined and reported.LIMITATIONS:Sparse evidence is available, applicable only to otherwise healthy children.CONCLUSIONS:Tympanostomy tubes improve hearing at 1 to 3 months compared with watchful waiting, with no evidence of benefit by 12 to 24 months. Children with recurrent acute otitis media may have fewer episodes after tympanostomy tube placement, but the evidence base is severely limited. The benefits of tympanostomy tubes must be weighed against a variety of associated adverse events.
Detection of an ALK Fusion in Colorectal Carcinoma by Hybrid Capture-Based Assay of Circulating Tumor DNA
Authors: Lai Andrea Z. , Schrock Alexa B. , Erlich Rachel L. , Ross Jeffrey S. , Miller Vincent A. , Yakirevich Evgeny , Ali Siraj M. , Braiteh Fadi 
Published: May 2017

Abstract
ALK rearrangements have been observed in 0.05%–2.5% of patients with colorectal cancers (CRCs) and are predicted to be oncogenic drivers largely mutually exclusive of KRAS, NRAS, or BRAF alterations. Here we present the case of a patient with metastatic CRC who was treatment naïve at the time of molecular testing. Initial ALK immunohistochemistry (IHC) staining was negative, but parallel genomic profiling of both circulating tumor DNA (ctDNA) and tissue using similar hybrid capture-based assays each identified an identical STRN-ALK fusion. Subsequent ALK IHC staining of the same specimens was positive, suggesting that the initial result was a false negative. This report is the first instance of an ALK fusion in CRC detected using a ctDNA assay.
A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases
Authors: Wang Victoria E. , Young Lauren , Ali Siraj , Miller Vincent A. , Urisman Anatoly , Wolfe John , Bivona Trever G. , Damato Bertil , Fogh Shannon , Bergsland Emily K. 
Published: May 2017

Abstract
A challenge in precision medicine requires identification of actionable driver mutations. Critical to such effort is the deployment of sensitive and well-validated assays for mutation detection. Although identification of such alterations within the tumor tissue remains the gold standard, many advanced non-small cell lung cancer cases have only limited tissue samples, derived from small biopsies or fine-needle aspirates, available for testing. More recently, noninvasive methods using either circulating tumor cells or tumor DNA (ctDNA) have become an alternative method for identifying molecular biomarkers and screening patients eligible for targeted therapies. In this article, we present a case of a 52-year-old never-smoking male who presented with widely metastatic atypical neuroendocrine tumor to the bones and the brain. Molecular genotyping using DNA harvested from a bone metastasis was unsuccessful due to limited material. Subsequent ctDNA analysis revealed an ALK translocation. The clinical significance of the mutation in this particular cancer type and therapeutic strategies are discussed.
Assisted Reproductive Technologies and the Right to Reproduce Under South African Law
Authors: Van Niekerk Carmel 
Published: May 2017

Reproductive rights in South Africa have traditionally focused on the rights of individuals to avoid reproduction. However, with an increase in the use of assisted reproductive technologies (ART), there has been a shift in the focus on reproductive rights from the rights of individuals to avoid reproduction to the rights of individuals to reproduce noncoitally.
With the emergence of new technologies, reproduction by noncoital means and the right to engage in these new technologies is becoming more prevalent. This raises two questions. The first question is whether such a right exists. The recent Constitutional Court decision in AB v Minister of Social Development 2017 3 BCLR 267 (CC) suggests that it does, but only if the person claiming this right is physically involved in the reproductive process. Ostensibly this excludes those who cannot contribute to the reproduction of a child.
The second question raised pertains to the impact of this right on specific forms of ART, namely mitochondrial transfer, posthumous reproduction and embryo donation. While the first two forms of ART would meet the criteria set down in AB, embryo donation would not. Individuals denied access to embryo donation could thus not rely on either the right to reproductive autonomy or the right to privacy to aid them. Fortunately the existing legal framework provides some assistance to these individuals, although sadly the same legislative framework does not support the use of mitochondrial transfer and posthumous reproduction. In this respect there is incongruence between rights and legislation, which has only been exacerbated by the recent Constitutional Court decision. What is thus needed is clarity on the meaning of certain rights in respect of certain forms of ART as well as legislative reform to reflect the clarified position.