bluuebunny/crossref_metadata_2025_split huggingface dataset:
The moderation effect of morphological awareness on the relationship between word detection skills and reading comprehension in Chinese children with and without dyslexia
Authors: Wang Li‐Chih , Liu Duo , Xu Zhengye 
Published: September 2024

AbstractThis study aimed to investigate the moderating effect of morphological awareness on the relationship between word detection skills and reading comprehension in Chinese children with and without dyslexia. The study included 116 Chinese children in third to sixth grades, with 60 children diagnosed with dyslexia and 56 matching typically developing children. ANCOVAs revealed significant group differences in word detection skills and morphological awareness, with children with dyslexia performing significantly worse than their typically developing peers. Partial correlation analyses showed significant correlations between reading comprehension and morphological awareness in typically developing children and between reading comprehension and both word detection skills and morphological awareness in children with dyslexia. Moderation analyses revealed that morphological awareness significantly moderated the relationship between word detection skills and reading comprehension in both groups. For typically developing children, the relationship was significant at higher levels of morphological awareness, while for children with dyslexia, the relationship was significant at lower levels of morphological awareness. The findings suggest that word detection skills may serve as a compensatory mechanism for children with dyslexia when morphological awareness is at lower levels, highlighting the need for targeted interventions and individualised approaches to reading instruction.
Sustainable solutions for direct TLC enantioseparation with in‐home thought‐out, prepared/modified chiral stationary phases
Authors: Bhushan Ravi 
Published: September 2024

AbstractTLC is used globally, yet less attention has been paid to TLC (in enantioseparation) despite its advantages. The present paper describes/reviews successfully practiced direct approaches of ‘chiral additive in achiral stationary phase’ (as an application of in‐home thought out, prepared, tested, and modified chiral stationary phase), ‘pre‐mixing of chiral reagent with the enantiomeric mixture’ (an approach using both achiral phases during chromatographic separation) and ‘chiral additive in mobile phase’, and chiral ligand exchange for enantioseparation of DL‐amino acids, their derivatives, and some active pharmaceutical ingredients. It provided efficient enantioseparation, quantitative determination, and isolation of native forms via in‐situ formation of non‐covalent diastereomeric pair. The mechanism of enantioseparation in these approaches has been discussed along with the isolation and establishment of the structure of diastereomers. This may help chemists gain useful insights into fields outside their specialization and the experts get brief accounts of recent key developments, providing solutions for sustainable development of less expensive methods for control of enantiomeric purity and isolation of native enantiomers.
RETRACTED: The interplay of corporate governance, internal audit effectiveness, and sustainable financial reporting quality in Tanzanian commercial banks
Authors: Ally Zawadi 
Published: September 2024

AbstractThis paper investigates the relationship between internal audit effectiveness, corporate governance attributes, and sustainable financial reporting quality within Tanzanian commercial banks. Grounded by agency cost theory to provide new insights into the determinants of financial reporting quality in a developing country context. A cross‐sectional and correlational research design was employed, utilizing a structured questionnaire distributed to 150 respondents across a representative sample of Tanzanian commercial banks. Data analysis was conducted using multiple linear regression techniques, with comprehensive diagnostic tests to ensure the robustness of the findings. The results indicate that larger board sizes and proactive board role performance significantly enhance financial reporting quality, reflecting the importance of strong governance structures. Board independence showed a significant impact on financial reporting quality, suggesting that board independence with active engagement contributes to financial reporting quality. Internal audit quality also emerged as a critical predictor of reliable financial reporting, underscoring the role of internal audit in promoting transparency and accountability. These findings contribute to the ongoing debate in corporate governance literature by providing evidence from a developing country perspective, highlighting the nuanced roles of governance and audit in shaping financial reporting quality. This study fills a key gap in the literature by focusing on the Tanzanian banking sector, offering practical recommendations for policymakers and practitioners aimed at enhancing the integrity of financial reporting. Policymakers should emphasize board independence and the active involvement of board members and strengthen internal audit functions to improve reporting transparency and accountability.
A CRISPR mediated point‐of‐care assay for the detection of mucosal calprotectin in an animal model of ulcerative colitis
Authors: Chia Selena , Guo Tianruo , Goldys Ewa M. , Payne Sophie C. , Duan Wenlu , Lovell Nigel H. , Shivdasani Mohit N. , Deng Fei 
Published: September 2024

AbstractInflammatory bowel disease (IBD) is a chronic disorder associated with inflammation in the gastrointestinal tract, leading to a range of debilitating symptoms. Fecal calprotectin is an established biomarker for ulcerative colitis (UC), one of the main IBD diseases, which provides indications of the presence and severity of inflammation in the digestive tract. Enzyme‐Linked Immunosorbent Assay (ELISA) as a gold standard approach for fecal calprotectin detection is time‐consuming and impractical in point‐of‐care settings. Moreover, obtaining fecal samples from patients is challenging and inhibits longitudinal monitoring. To address these specific problems, we have developed a novel approach for detecting calprotectin which leverages clustered regularly interspaced short palindromic repeats (CRISPR)/Cas technology. We successfully developed a portable tube‐based CRISPR/Cas assay for point‐of‐care testing of calprotectin. This assay showed a detection range from 1 to 10,000 ng/ml (over 4 log units), using both fluorescent and colorimetric analytical techniques. The established assay was further validated through measurements in mucosal samples obtained in an anesthetised preclinical rodent model of UC, with 2–3 times higher calprotectin concentration detected in UC rat samples compared to that of healthy control animals. This point‐of‐care test may provide a rapid, precise, and user‐friendly approach for the diagnosis and monitoring of IBD through mucosal sample testing.
Hyperspectral imaging facilitating resect‐and‐discard strategy through artificial intelligence‐assisted diagnosis of colorectal polyps: A pilot study
Authors: Peng Cheng , Tian Chong Xuan , Mu Yijun , Ma Mingjun , Zhang Zhenlei , Wan Meng , Liu Jing , Li Zhen , Zuo Xiuli , Li Wei , Li Yanqing 
Published: September 2024

AbstractBackground and AimsThe resect‐and‐discard strategy for colorectal polyps based on accurate optical diagnosis remains challenges. Our aim was to investigate the feasibility of hyperspectral imaging (HSI) for identifying colorectal polyp properties and diagnosis of colorectal cancer in fresh tissues during colonoscopy.Methods144,900 two dimensional images generated from 161 hyperspectral images of colorectal polyp tissues were prospectively obtained from patients undergoing colonoscopy. A residual neural network model was trained with transfer learning to automatically differentiate colorectal polyps, validated by histopathologic diagnosis. The diagnostic performances of the HSI‐AI model and endoscopists were calculated respectively, and the auxiliary efficiency of the model was evaluated after a 2‐week interval.ResultsQuantitative HSI revealed histological differences in colorectal polyps. The HSI‐AI model showed considerable efficacy in differentiating nonneoplastic polyps, non‐advanced adenomas, and advanced neoplasia in vitro, with sensitivities of 96.0%, 94.0%, and 99.0% and specificities of 99.0%, 99.0%, and 96.5%, respectively. With the assistance of the model, the median negative predictive value of neoplastic polyps increased from 50.0% to 88.2% (p = 0.013) in novices.ConclusionThis study demonstrated the feasibility of using HSI as a diagnostic tool to differentiate neoplastic colorectal polyps in vitro and the potential of AI‐assisted diagnosis synchronized with colonoscopy. The tool may improve the diagnostic performance of novices and facilitate the application of resect‐and‐discard strategy to decrease the cost.
Unraveling the impact of lysosomal dysfunction on myeloproliferative neoplasm
Authors: Yoon Hyundong , Lee Dohoon , Song Seulki , Koo Bonil , Park Jihyun , Kim Tae Kon , Kim Sun , Kim Sheehyun , Hong Junshik , Byun Ja Min , Shin Dong‐Yeop , Kim Inho , Koh Youngil , Yoon Sung‐Soo 
Published: September 2024

AbstractBackgroundLysosomal dysfunction (LD) impacts cytokine regulation, inflammation, and immune responses, influencing the development and progression of cancer. Inflammation is implicated in the pathogenesis of myeloproliferative neoplasm (MPN). With a hypothesis that LD significantly contributes to MPN carcinogenesis by inducing abnormal inflammation, our objective was to elucidate the pathophysiological mechanisms of MPN arising from an LD background.MethodsGenotyping of the LD background was performed in a cohort of MPN patients (n = 190) and healthy controls (n = 461). Logistic regression modeling, utilizing genotype data, was employed to estimate the correlation between LD and MPN. Whole transcriptome sequencing (WTS) (LD carriers = 8, non‐carriers = 6) and single‐cell RNA sequencing data (LD carriers = 2, non‐carriers = 2, healthy controls = 2) were generated and analyzed.ResultsA higher variant frequency of LD was observed in MPN compared to healthy controls (healthy, 4.9%; MPN, 7.8%), with the highest frequency seen in polycythemia vera (PV) (odds ratio = 2.33, p = 0.03). WTS revealed that LD carriers exhibited upregulated inflammatory cytokine ligand–receptor genes, pathways, and network modules in MPNs compared to non‐carriers. At the single‐cell level, there was monocyte expansion and elevation of cytokine ligand–receptor interactions, inflammatory transcription factors, and network modules centered on monocytes. Notably, Oncostatin‐M (OSM) consistently emerged as a candidate molecule involved in the pathogenesis of LD‐related PV.ConclusionsIn summary, an LD background is prevalent in MPN patients and leads to increased cytokine dysregulation and inflammation. OSM, as one of the potential molecules, plays a crucial role in PV pathogenesis by impairing lysosomal function.
Predicting treatment success and failure using routine outcome data: The role of therapist effects in dynamic predictive modelling
Authors: Mahon Daryl , Minami Takuya , Brown Jeb 
Published: September 2024

AbstractBackgroundThe goal of this research was to identify how early in psychotherapy a reliable prediction regarding the probability of premature termination, treatment failure or treatment success can be made, and which variables are most predictive. This research breaks new ground by including data on each clinician's historical outcomes (therapist effects) to explore to what degree predictions and decision rules might differ with therapist effectiveness.Materials & MethodsData was drawn from a large online database of clients regularly completing self‐report outcome questionnaires. The sample included clinicians (n = 1020) treating clients (n = 68,690) with an intake score in the clinical range during a treatment episode of between 2 and 10 sessions. Variables available at the first session and later sessions were tested for predictive validity for status at subsequent sessions using general linear regression models and logistic regression models.ResultsThe results suggest that therapy outcomes can be predicted as early as the second session with a good degree of accuracy, 65%. The analyses revealed that predictions made as early as the second session remain valid even for clients taking up to 10 sessions to complete treatment. Adding therapist effects to the predictive model provides a much more nuanced understanding of the results. By session two, therapists in the top quartile demonstrate effect sizes comparable to the effect sizes of bottom quartile therapists at session ten.ConclusionThe probability of client success, failure or early termination varies significantly depending on the clinician. Implications for training and supervision are discussed.
An exploration of psychotherapists' readiness to join the psychedelic renaissance
Authors: Scanlon Siobhan , Donohue Gráinne 
Published: September 2024

AbstractBackgroundResearch on psychedelics centres on two key areas: the action of psychedelics on the brain and the protocol for delivering therapy. There is little research that considers the implications of this novel therapy on the therapist delivering the treatment. This research study sought to explore this.Aim and ObjectivesThe aim of this research was to explore the considerations for psychotherapists interested in delivering psychedelic therapy. Objectives were to examine the therapeutic conditions needed for effective outcomes, to explore the perceived differences between the practice of standard psychotherapy and psychedelic therapy and to determine the challenges for therapists working in the field.MethodSix semi‐structured interviews were conducted with therapists who work in clinical or retreat settings. Interview transcripts were analysed using qualitative thematic analysis.FindingsThree themes emerged that highlight the importance of preparation for effective clinical outcomes, the differences in standard and psychedelic practice and the personal and professional implications for therapists.ConclusionsThe results highlighted challenges and revealed the need for clear protocols for integrating psychedelics into psychotherapy practice.
Aromatic Abietane‐Type Diterpenoids from the Roots of Salvia prattii and their Protective Activity Against Alcoholic Liver Disease
Authors: Zhang Ming , Yang Yi‐Ran , Chen Yan‐Fang , Ren Fu‐Cai , Pu Xiang‐Dong , Shen Chuan‐Pu 
Published: September 2024

AbstractEighteen aromatic abietane‐type diterpenes, including three previously unreported compounds, Salkanoids A−C (1–3), were isolated from the roots of Salvia prattii. Their stuctures were extensively elucidated using 1D/2D NMR, high‐resolution electrospray ionization mass spectrometry (HRESIMS) data, and ECD calculation. Among these, compounds 1, 6 and 7 belong to a class of diterpenes featuring a [5, 5]‐oxaspirolactones moiety, a rare structure isolated from the Salvia plants. All the isolates were assessed for their protective effects against alcoholic liver disease using ethanol‐induced AML‐12 cell lines. The findings revealed that compounds 2, 5, 8 and 15 demonstrated potential protective activity.
Synthesis and Acetylcholinesterase Inhibitory Activity of Novel Trilaciclib Analogs
Authors: Muzychka Liubov , Muzychka Oksana , Smolii Oleg 
Published: September 2024

AbstractTrilaciclib is a CDK4/6 inhibitor, used to treat the bone marrow damage in chemotherapy patients. A series of thirteen novel structural trilaciclib analogs was obtained to evaluate their activity against acetylcholinesterase. An effective method for the synthesis of 4,7‐substituted 8,9‐dihydropyrazino[1’,2’:1,5]pyrrolo[2,3‐d]pyrimidine derivatives from a new methyl 4‐chloro‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxylate was developed. Most of the synthesized pyrazino[1’,2’:1,5]pyrrolo[2,3‐d]pyrimidine derivatives inhibited acetylcholinesterase in the micromolar range. The obtained data can be used for designing more potent acetylcholinesterase inhibitors with the pyrazino[1’,2’:1,5]pyrrolo[2,3‐d]pyrimidine scaffold.
Isolation of Novel Compounds from Lepidium sativum Seeds and Evaluation of Their Potential Anti‐Tumor Activity
Authors: Shybyray Yergazy , Kaiyrkulova Aida , Zhao Hai‐Qing , Jenis Janar , Aisa Haji Akber , Li Jun 
Published: September 2024

AbstractFour undescribed compounds including a pair of enantiomers of a dihydroarylnaphthalene lignan [(±)−1], an arylnaphthalene lignan (2), and an indoleacetic acid ester (3), together with four known compounds (4–7), were isolated from the seeds of Lepidium sativum. Their structures were identified by HRMS and NMR spectroscopic data, and the absolute configuration of these compounds were assigned by ECD data in combination with quantum chemical calculations. Compound (−)−1 had weak inhibitory activity against HeLa cell line with an IC50 value of 60.23±3.51 μM, and compound (+)−1 presented moderate inhibitory effect against HeLa cell line with an IC50 value of 19.99±1.00 μM (IC50 value of the positive control was 0.40±0.02 μM).
Discovery of Arylpiperazines with Broad‐Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles
Authors: da Silva Oliveira Douglas Davison , Sousa Silva Nagela Bernadelli , Jacques Dit Lapierre Thibault Joseph William , Lemes de Souza Sara , Ferreira Brito Nícolas Peterson , Cassiano Martinho Ana Clara , Clemente Dias Renieidy Flávia , Nascimento Farago Danilo , Michelan‐Duarte Simone , Consolin Chelucci Rafael , de Moura Lodi Cruz Mariza Gabriela Faleiro , de Melo Resende Daniela , Andricopulo Adriano D. , Fonseca Murta Silvane Maria , Ferreira Leonardo L. G. , Gomes Martins Carlos Henrique , de Oliveira Rezende Júnior Celso 
Published: September 2024

AbstractMicroorganisms can induce diseases with significant clinical implications for human health. Multidrug‐resistant microorganisms have been on the rise worldwide over the past few decades, and no new antibiotics have been introduced to the market in a considerable amount of time. Such situation highlights the urgency of discovering new antimicrobial drugs to address this pressing issue. Therefore, the objective of this study was to identify bioactive compounds against 15 species of bacteria and 5 species of fungi of clinical relevance through in vitro screening of 58 synthetic compounds from four chemical classes of our internal library of synthetic compounds. Our findings highlight arylpiperazines 18, 20, 26, 27, and 29, and the aminothiazole 50, as potent broad‐spectrum antimicrobials (MICs=12.5–15.6 μg mL−1) against clinically relevant bacteria and fungi. Additionally, these compounds displayed low cytotoxicity against various host cells and a favorable in vitro pharmacokinetic profile for oral administration. Indeed, all six showed adequate lipophilicity, high gastrointestinal permeability, metabolic stability in human and mouse liver microsomes, and satisfactory aqueous solubility. Thus, they emerge as promising starting points for hit‐to‐lead studies towards new antibacterial and antifungal agents, especially against Staphylococcus epidermidis, Staphylococcus aureus, Lactobacillus paracasei and Candida orthopsilosis.
Photoactivable CRISPR for Biosensing and Cancer Therapy
Authors: Wang Siyuan , Wang Jiaqi , Li Baijiang , Zhang Jingjing 
Published: September 2024

AbstractPhotoactivable CRISPR technology represents a transformative approach in the field of genome editing, offering unprecedented control over gene editing with high spatial and temporal precision. By harnessing the power of light to modulate the activity of CRISPR components, this innovative strategy enables precise regulation of Cas proteins, guide RNAs, and ribonucleoprotein complexes. Recent advancements in optical control methodologies, including the development of photoactivable nanocarriers, have significantly expanded the potential applications of CRISPR in biomedical fields. This Concept highlights the latest developments in designing photoactivable CRISPR systems and their promising applications in biosensing and cancer therapy. Additionally, the remaining challenges and future trends are also discussed. It is expected that the photoactivable CRISPR would facilitate translating more precise gene therapies into clinical use.
Advanced laryngeal squamous cell carcinoma in an adolescent: A case and treatment considerations
Authors: Hunter Courtney J. , Moreno Mauricio A. , Strub Graham M. 
Published: September 2024

Key Clinical MessagePediatric laryngeal SCCa is a rare malignancy in childhood. High index of suspicion is critical to obtain timely tissue sample and diagnosis. Shared decision making is important when choosing treatment modalities for curative management, especially when working with adolescent patients.
Ca/Li Synergetic‐Doped Na0.67Ni0.33Mn0.67O2 to Realize P2‐O2 Phase Transition Suppression for High‐Performance Sodium‐Ion Batteries
Authors: Xiao Ke , Zhao Bangchuan , Bai Jin , Mao Yunjie , Wang Peiyao , Wang Siya , Zhu Xuebin , Sun Yuping 
Published: September 2024

AbstractP2‐type layered transition metal oxide Na0.67Ni0.33Mn0.67O2 is considered as a promising cathode for advanced sodium‐ion batteries due to its high theoretical specific capacity. However, the P2‐type cathode suffers severe P2‐O2 phase transition during cycling process, resulting unsatisfactory cyclic stability and rate capability. Herein, a Ca/Li co‐doped P2‐type Na0.62Ca0.05Ni0.33Mn0.57Li0.10O2 (NCNMLO) cathode material was synthesized through a simple sol‐gel method. With the synergistic effect of Ca‐doping at Na sites and Li substitution at transition metal (TM) sites, the cathode achieves an excellent electrochemical performance due to the inhibited P2‐O2 phase transition and improved ion diffusion with Na+/vacancy disordering arrangement. The NCNMLO cathode exhibits a good cyclic stability with 70.8 % of capacity retention at 1 C after 200 cycles and excellent rate capability with 40.1 mAh g−1 at 20 C. The dual sites doping strategy provides an effective and simple approach for designing high‐performance layered oxide cathode materials for sodium‐ion batteries.
Pathway‐dependent Metallosupramolecular Polymerization Regulated by Ligand Geometry
Authors: Sutar Papri , Maisuls Iván , Fernández Zulema , Strassert Cristian A. , Fernández Gustavo 
Published: September 2024

AbstractUnderstanding structure/property correlations in self‐assembly is a key but challenging requirement for developing functional materials. Herein, we explore the importance of ligand geometry to fine‐tune photophysical properties (MMLCT vs. MLCT excited states) and self‐assembly pathways in metallosupramolecular polymerization. To this end, we have designed two hydrophobic Pt(II) complexes, 1 and 2, containing a π‐extended bidentate bipyridine ligand with different substitution pattern, resulting in different molecular geometries (linear vs. V‐shaped). Detailed comparative studies revealed significant differences for both complexes in terms of their photophysical properties and self‐assembly pathways in non‐polar media. The V‐shaped topology of 1 enables facile face‐to‐face molecular stacking with a certain curvature leading to luminescent spherical assemblies exhibiting MMLCT states and short Pt⋅⋅⋅Pt contacts via a single‐step cooperative pathway. On the other hand, the higher preorganized linear topology of complex 2 induces a two‐step competitive self‐assembly process leading to the formation of one‐dimensional supramolecular polymers with slipped packing and MLCT‐originated emission. Our findings broaden the monomer scope for supramolecular polymerization and provide design guidelines for the realization of luminescent supramolecular assemblies.