bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychophysical changes after total sleep deprivation and experimental muscle pain
Authors: Hertel Emma , Sathiyalingam Elaxmi , Pilgaard Linea , Brommann Simone Juline , Giordano Rocco , Petersen Kristian Kjær‐Staal 
Published: September 2024

SummarySleep disturbances exacerbate chronic pain, increase psychological load, and increase inflammation. Delayed onset muscle soreness (DOMS) mimics aspects of chronic pain, predominantly affecting peripheral pain mechanisms, while experimental sleep provocations have been shown to impact central pain mechanisms. This study aimed to combine a DOMS model with total sleep deprivation (TSD) to create a novel model affecting both peripheral and central pain mechanisms. A total of 30 healthy participants attended two sessions (baseline and follow‐up) separated by 24 h of TSD and a home rating after 48 h. Assessments of interleukin 6 (IL‐6) levels, sleep quality, pain catastrophising, affect, and symptoms of depression and anxiety were included in the baseline and follow‐up sessions. Additionally, pressure pain and tolerance thresholds, temporal summation, and conditioned pain modulation (CPM) were assessed using cuff‐pressure algometry in the baseline and follow‐up sessions. DOMS was induced with eccentric calf raises during the baseline session followed by 24 h of TSD. At follow‐up pain tolerance (p = 0.012) was significantly reduced, and CPM (p = 0.036) was significantly impaired compared to baseline. Psychological changes included decreases in pain catastrophising (p = 0.027), positive affect (p < 0.001), negative affect (p = 0.003), and anxiety (p = 0.012). Explorative regression models predicted 58% and 68% of DOMS pain intensity after 24 and 48 h, respectively, based on baseline body mass index, pain thresholds, psychological measures, and IL‐6 (p < 0.01). Combining DOMS with 1 night of TSD induced pain hypersensitivity, impaired CPM, and altered psychological states. A combination of baseline inflammation, psychological measures, and pain sensitivity significantly predicted DOMS pain intensity after 24 and 48 h.
Overwintering humpback whales adapt foraging strategies to shallow water environments at the mouth of the Chesapeake Bay, Virginia, USA
Authors: Shearer Jeanne M. , Foley Heather J. , Swaim Zachary T. , Janik Vincent M. , Read Andrew J. 
Published: September 2024

AbstractSome humpback whales from the Northwestern Atlantic population forgo migration to the Caribbean, spending winter months feeding along the U.S. mid‐Atlantic coast. We studied the foraging behavior of these whales at the mouth of the Chesapeake Bay, Virginia during winter from 2017 to 2022. While shipping channels here reach depths of up to 30 m, most of the area is 11–15 m deep. This shallow‐water environment poses physical constraints on classical humpback whale feeding modes. We deployed 20 digital acoustic tags (DTAGs) on humpback whales and identified foraging lunges from accelerometer data, detecting 788 lunges from 10 animals. Tagged whales averaged a single lunge per dive, lunging primarily in a horizontal orientation, with limited maneuvering compared to other study sites. Our results indicate that some elements of humpback whale foraging behavior are conserved across environments, but that the shallow depths in our study area constrain how animals are able to feed. The relatively high lunge rates we observed suggest this area is an important foraging ground. However, foraging in shipping channels increases the risk of ship strikes, which frequently occur in this area.
Prognostic impact of caspase‐8 mutation in oral cavity squamous cell carcinoma
Authors: Lu Hsueh‐Ju , Su Chun‐Wen , Su Shih‐Chi , Chang Lun‐Ching , Wu Ming‐Fang , Lin Chiao‐Wen , Yang Shun‐Fa 
Published: September 2024

AbstractObjectiveIdentifying the drive genes and inhibiting their significant signals were persistently the main concepts in cancer treatment. However, for oral cavity squamous cell carcinoma (OCSCC), the most influential genes for overall survival (OS) remain unclear.MethodsA total of 120 OCSCC patients with corresponding pathologic specimens were collected in Taiwan. Whole‐exome sequencing was done and the prognostic impact of each gene was analyzed. TCGA database was used to validate.ResultsThe incidences of caspase‐8 mutation were 22.1% and 10.9% in the Taiwan and TCGA cohort, respectively. In the Taiwan cohort, caspase‐8 mutation was the most significant independent for OS with an adjusted hazard ratio (HR) ([95% CI]: 3.83 [1.84–7.99]). It was validated by the TCGA database (HR [95% CI]: 1.51 [1.00–2.29]). The 5‐year OSs of the patients with or without caspase‐8 mutation were 38.1% vs. 75.3% (p < 0.001) (HR [95% CI]: 3.264 [1.645–6.438]) in the Taiwan cohort, and 26.1% vs. 49.0% (p = 0.048) (1.513 [1.001–2.288]) in the TCGA cohorts, respectively. Caspase‐8 mutation was also individually associated with poor prognosis for TNM stage I/II/III/IV, respectively. CASP8 R127* and R494*, defined as pathogenic mutations in ClinVar, were presented in both cohorts.ConclusionsCaspase‐8 mutation was the most significant genetic alteration impacting prognosis.
From non‐renewables to renewables and high‐tech production: The impact of natural wealth and technology on ecological load capacity in sub‐Saharan Africa
Authors: Nwani Chinazaekpere , Okere Kingsley Ikechukwu , Dimnwobi Stephen Kelechi , Uche Emmanuel , Iorember Paul Terhemba 
Published: September 2024

AbstractIn the face of growing sustainability challenges, this study examines the ecological impacts of natural wealth (NR) and tech‐driven industrial diversification (TID) in sub‐Saharan Africa (SSA). It employs the load capacity factor (LCF), utilizing a panel dataset spanning from 1991 to 2020. The findings reveal that renewable (forest) resources exert a positive and significant influence on LCF, primarily at lower quantiles. When the resource basket is adjusted to include mineral resources, this impact turns negative across all quantiles, with statistical significance evident at the upper quantiles. Further modifications to the resource basket, including energy extraction such as oil, coal, and natural gas, yield a statistically significant negative impact on LCF across the lower, median, and upper quantiles. Additionally, TID has a positive impact on LCF in the upper quantiles. Robustness analysis confirms that the covariates indeed Granger‐cause LCF. This finding also indicates that the causal equation is significantly influenced by past values of NR and TID. The Half‐Panel Jackknife estimator reaffirms that, on average, TID has a positive effect on LCF in the region. These findings suggest enhancing growth through renewables and industrial capacity in medium‐ and high‐tech industries as part of broader sustainability strategies in the SSA region.
Impacting elementary STEM teacher leadership identities
Authors: Quaisley Kelsey , Funk Rachel , Pai Leilani , Ahrens Sally , Smith Wendy M. , Thomas Amanda 
Published: September 2024

AbstractLearning science, technology, engineering, and mathematics (STEM) subjects starting at a young age helps prepare students for a variety of careers both inside and outside of the sciences. Yet, addressing integrated STEM in an elementary school setting can be challenging. Teacher leadership is one way to address this challenge. The purpose of this qualitative, descriptive case study is to understand how participation in the NebraskaSTEM Noyce Master Teaching Fellowship project impacted elementary STEM teacher leadership identities. Our findings suggest participation in the project contributed to different layers of teacher leadership identity (as a STEM learner, as a STEM teacher, and as a STEM teacher leader). These findings suggest professional development should be tailored to address empowering specific layers of STEM teacher leaders' professional identity. Other teacher leadership development projects may want to consider how to structure their projects to empower teachers based on the identities and experiences of those teachers.
ANTI-CANCEROUS POTENTIAL OF POLYSACCHARIDES DERIVED FROM WHEAT CELL CULTURE
Authors: Murtazina A.S. , Marchal J.A. , Tarabayeva A.S. , Bitanova E.Zh. , McDougall G. , Tassi H.B. , Bishimbayeva N.K. 
Published: September 2024

There is a global need to discover effective anti-cancerous compounds from natural sources. Cultivated wheat cells can be a valuable source of non-toxic or low toxic plant-derived polysaccharides. In this study we evaluated the antitumor ability of seven fractions of wheat cell culture polysaccharides (WCCPSs) in the HCT-116 colon cancer cell line.
Almost all (6/7) fractions had an inhibitory effect on the proliferation of colon cancer cells, and two fractions (A-b and A-f) had considerable therapeutic indexes. The WCCPS fractions induced cell cycle arrest in the G1 phase and induced different rates of apoptosis (<48%). Transmission and scanning electron microscopy revealed that WCCPS fractions caused apoptotic changes in the nucleus and cytoplasm, including damage to mitochondria and external morphological signs of apoptosis.
In addition, the WCCPSs induced an increase in the levels of Bax, cytochrome c, caspases 8 and 3, indicating that cell death was assessed through intrinsic and extrinsic pathways of apoptosis. Furthermore, some fractions caused a significant decrease of c-Myc, b-catenin, NFkB2 and HCAM (CD 44) levels, indicating enhanced cell differentiation. Thus, for the first time, our results provide a proof of concept of the anti-cancer capacity of WCCPS fractions in colorectal cancer.
This research was supported by the FEDER Operational Program 2020/Junta de Andalucía-Consejería de Economía y Conocimiento/ Project (B-CTS-562-UGR20) and the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963); Erasmus+ Mobility Program; “Bolashak” Presidential Scholarship of the Republic of Kazakhstan for scientific work abroad; Scottish Government’s Rural and Environment Science and Analytical Services (RESAS) division.
ПРИМЕНЕНИЕ ЛЮМИНЕСЦЕНТНО-МИКРОСКОПИЧЕСКОГО И ИММУНОФЕРМЕНТНОГО МЕТОДОВ ИССЛЕДОВАНИЯ НЕТОЗА ПРИ ТУБЕРКУЛЕЗНОЙ ИНФЕКЦИИ У ДЕТЕЙ (ДОКЛАД ПОДГОТОВЛЕН ПРИ ПОДДЕРЖКЕ ГРАНТА РОССИЙСКОГО НАУЧНОГО ФОНДА № 23-25-10043)
Authors: Новиков Д.Г. , Индутный А.В. , Золотов А.Н. , Мордык А.В. 
Published: September 2024

Нетоз – вид программируемой клеточной смерти нейтрофильных лейкоцитов, сопровождающейся выбросом нейтрофильных внеклеточных ловушек (НВЛ) и играющий значительную роль в механизмах развитии многих инфекционных заболеваний, в том числе туберкулеза. При этом, несмотря на имеющиеся особенности развития туберкулезной инфекции в детском возрасте, процесс образования НВЛ практически не изучен в этой возрастной группе.
Для исследования нетоза была предложена запатентованная коллективом авторов методика оценки НВЛ, полученных при воздействии неспецифического антигенного стимулятора – культуры микроорганизмов Lactobacillus reutri, L. acidophilius, L. rhamnosis и Bifidumbacterium longum на нейтрофильные лейкоциты, выделенные из перифирической венозной крови на градиенте плотности раствора фиколла-верографина. Вне- и внутриклеточную ДНК визуализировали при помощи интеркалирующего красителя йодида пропидия, нейтрофильные лейкоциты – при помощи моноклональных антител к CD15, меченных флуоресцентным красителем FITC.
При сравнительном исследовании, проведенном с помощью данной методики у взрослых и детей (4-7 лет), больных туберкулезом было выявлено, что у детей нейтрофилы при воздействии неспецифического антигенного стимулятора интенсивнее, чем у взрослых, формировали нитевидные НВЛ (p=0,0131). При этом было обнаружено, что преимущественно нитевидные НВЛ формировались и у здоровых детей из группы контроля, но в меньшем количестве, чем у детей у диагностированным первичным туберкулёзным комплексом (p=0,0046). Напротив, нейтрофилы взрослых с инфильтративной или очаговой формой туберкулеза чаще формировали облаковидные НВЛ (p=0,0000).
Также было обнаружено, что в группе с латентной туберкулезной инфекцией нетозобразующая способность нейтрофилов была выше в сравнении с контрольной группой. У данной группы детей также чаще наблюдались нитевидные НВЛ (p=0,0297).
Цитруллинированный гистон Н3 (citH3) – продукт посттрансляционной модификации белков, имеющей место в том числе в процессе нетоза. Уровни citH3 оценивали в периферической крови с помощью тест-системы «Citrullinated Histone H3 (Clone 11D3) ELISA Kit» (Cayman Chemical Company, США). Была выявлена сильная корреляционная взаимосвязь между концентрацией citH3 и формированием нитевидных НВЛ (r=0,86; p=0,0137).
Таким образом, обе рассматриваемые методики могут использоваться для исследования туберкулезной инфекции у детей, показывая достаточно высокую степень сходимости результатов.
Essential Improvements in Fat Percentage and Cardiometabolic Fitness After a Residential Stay for Socially Vulnerable Children—With and Without the “11 for Health” Concept
Authors: Møller Trine K. , Krustrup Peter , Brønd Jan C. , Geiker Nina R.W. , Larsen Malte N. 
Published: September 2024

The Danish Christmas Seal Homes offer a 10-week residential stay for socially vulnerable children. We aimed to examine the effects on body composition and cardiometabolic fitness variables of the standard program (SG) and whether substituting physical activity sessions with sessions from a football-based health education program is beneficial for the participants (“11 for Health”; SG+). Three hundred and nine children participated in SG (12.4 [1.6] y) and 305 in SG+ (12.4 [1.4] y). Fat percentage was lowered by 6% for females (from 37% to 31%) and 8% for males (from 36% to 28%), with no between-group differences. We observed improvements in systolic and diastolic blood pressure (3 and 5 mm Hg, respectively), resting heart rate (10 beats/min), aerobic fitness, jump performance, and relative muscle mass with no between-group differences. Furthermore, there were between-group differences in insulin levels for females (1.7 pmol/L; 95% CI, 0.3 to 3.0) and postural balance for males (1.0 s; 95% CI, 0.0 to 2.0), both in favor of SG+, and covered distance in the Andersen test for females (26 m; 95% CI, 3 to 49) in favor of SG. In conclusion, a 10-week stay at the Danish Christmas Seal Home resulted in clinically relevant improvement in fat percentage and cardiometabolic fitness in socially vulnerable children, regardless of the program type.
Offline data processing system of the BESIII experiment
Authors: Zou Jiaheng , Li Weidong , Ma Qiumei , You Zhengyun , Sun Shengsen , Deng Ziyan , Ji Xiaobin , Zhemchugov Alexy , Fang Wenxing , Fu Chengdong , He Kanglin , Huang Xingtao , Lin Tao , Liu Chunxiu , Liu Huaimin , Mao Zepu , Qiu Jinfa , Sun Yongzhao , Wen Shuopin , Wu Linghui , Wang Liangliang , Yuan Ye , Zhang Yao , Zhang Xiaomei , Zhao Guang 
Published: September 2024

AbstractThe BESIII experiment has been operating since 2009 and has received several upgrades, to study the $$\tau $$
τ
-charm physics utilizing the BEPCII accelerator. The BEPCII is a double-ring multi-bunch collider with a luminosity of $$1 \times 10^{33} \, {\text {cm}}^{-2} \, {\text {s}}^{-1}$$

1
×

10
33

cm

-
2

s

-
1

optimized at a center-of-mass (cms) energy of $$2 \times 1.89$$

2
×
1.89

GeV. The rich physics topics, long lifetime and the large volume of data present challenges to offline data processing. This paper describes the design and implementation of the offline software system to meet the requirements and challenges of BESIII, including offline software architecture, geometry management, database management, event data model and tag-based analysis.
Investigating $$D^0$$ meson production in p-Pb collisions at 5.02 TeV with a multi-phase transport model
Authors: Zhang Chao , Zheng Liang , Shi Shusu , Lin Zi-Wei 
Published: September 2024

AbstractWe study the production of $$D^0$$

D
0

meson in p+p and p-Pb collisions using the improved AMPT model considering both coalescence and independent fragmentation of charm quarks after the Cronin broadening is included. After a detailed discussion of the improvements implemented in the AMPT model for heavy quark production, we show that the modified AMPT model can provide a good description of $$D^0$$

D
0

meson spectra in p-Pb collisions, the $$Q_{\textrm{pPb}}$$

Q
pPb

data at different centralities and $$R_{\textrm{pPb}}$$

R
pPb

data in both mid- and forward (backward) rapidities. We also studied the effects of nuclear shadowing and parton cascade on the rapidity dependence of $$D^{0}$$

D
0

meson production and $$R_{\textrm{pPb}}$$

R
pPb

. Our results indicate that using the same strength of the Cronin effect (i.e $$\delta $$
δ
value) as that obtained from the mid-rapidity data leads to a considerable overestimation of the $$D^0$$

D
0

meson spectra and $$R_{\textrm{pPb}}$$

R
pPb

data at high $$p_{\textrm{T}}$$

p
T

in the backward rapidity. As a result, the $$\delta $$
δ
is determined via a $$\chi ^2$$

χ
2

fitting of the $$R_{\textrm{pPb}}$$

R
pPb

data across various rapidities. This work lays the foundation for a better understanding of cold-nuclear-matter (CNM) effects in relativistic heavy-ion collisions.
Unmet Need for Modern Contraceptive Methods Among Displaced Married Women in Their Reproductive Years in Bishan Guracha Town, West Arsi Zone, Oromia Region, Ethiopia
Authors: Million Sisay , Gebru Zeleke , Hassen Sultan , Tesfaye Selamnesh 
Published: September 2024

Background: Refugees and conflict‐affected areas are often unreached by national strategies and programs. As a result, high unmet needs are more likely because of their social interruption with their traditional information sources, support, protection, and lack of income which limits refugees’ ability to make a free choice that would allow them to plan and space the number of children they desire. Information on the unmet needs of internally displaced persons (IDPs) women is scarce. This study is aimed at assessing the magnitude of the unmet need for modern contraceptive methods and associated factors among IDPs currently married reproductive‐age women.Methods: A community‐based cross‐sectional study was conducted among 393 internally displaced women currently married reproductive‐age women using a simple random sampling method using a structured, pretested, and interview‐administered questionnaire. A logistic regression model was used to identify associated factors. Statistically significant variables at p value < 0.25 in the bivariate analysis were entered into multivariable analysis, and statistical significance was declared at p value ≤ 0.05.Results: About 160 (40.7%) (95% CI: 35.94%–45.67%) of women had an unmet need for modern contraceptive methods, 139 (35.4%) for spacing, and 21 (5.3%) for limiting. Less than 18 years of age at first marriage, lack of access to modern contraception, lack of discussion with healthcare providers, and travel time of 30 min or more to obtain family planning were found to be risk factors for unmet contraceptive needs. The risk of unmet need for modern contraceptives was high among women who were married at age of less than 18 years of age in comparison with women who were married at 18 and above (AOR = 1.559; 95%CI = 1.019–2.385). Unmet needs were higher among participants who had no adequate availability of modern contraceptive methods than those who had adequate availability of modern contraceptive methods (AOR = 1.738; 95%CI = 1.125–2.684). Similarly, the odds of unmet needs were 1.673 times higher among participants who did not discuss FP with healthcare providers than those who discussed FP with healthcare providers (AOR = 1.673; 95%CI = 1.085–2.581). Moreover, the odds of unmet needs were 1.551 times higher among participants who traveled 30 min and above to access family planning services as compared to those respondents who traveled below 30 min (AOR = 1.551; 95%CI = 1.002–2.401).Conclusion and Recommendations: The magnitude of the unmet need for modern contraceptive methods was higher than both the Ethiopian national and Oromia regional state total unmet need for the general population. Governmental and nongovernmental organizations should increase their efforts to reduce this high magnitude of unmet needs by emphasizing those factors that have a great contribution to unmet needs.
METTL protein family: focusing on the occurrence, progression and treatment of cancer
Authors: Zhang Huhu , Sun Fulin , Jiang Shuyao , Yang Fanghao , Dong Xiaolei , Liu Guoxiang , Wang Mengjun , Li Ya , Su Mohan , Wen Ziyuan , Yu Chunjuan , Fan Chenkai , Li Xiaoxia , Zhang Zhe , Yang Lina , Li Bing 
Published: September 2024

AbstractMethyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of biological behaviours in normal organisms and diseases, characterised by the presence of a methyltransferase-like structural domain and a structurally conserved SAM-binding domain formed by the seven-stranded β-fold structure in the center of the protein. With the deepening of research, the METTL protein family has been found to be abnormally expressed in a variety of tumor diseases, and the clarification of its relationship with tumor diseases can be used as a molecular therapeutic target and has an important role in the prognosis of tumors. In this paper, we review the structure, biological process, immunotherapy, drug-targeted therapy, and markers of the METTL protein family to provide new ideas for the diagnosis and treatment of tumors.
Mysticism and the Postanarchist Symbolic
Authors: Lewis Keith 
Published: September 2024

Abstract
This article engages with Meister Eckhart's mystical theology and Lacanian psychoanalysis to explore the role that mysticism can play in the production of an alternative symbolic order that can form the basis for a reenchantment of the world as part of the postanarchist insurrection of the self and project of structural renewal. More specifically, it draws from Meister Eckhart's conceptualization of the Godhead to argue that the positioning of the Godhead as the primary master signifier for the political community can contribute toward the production of an alternative, mystical postanarchist Symbolic founded on a sovereignty of the Godhead oriented toward the deconstruction of the symbolic systems out of which contemporary forms of domination and control emerge. In doing so, it argues that this mystical approach to postanarchism can contribute toward the undoing of the symbolic law through which neoliberal sovereignty is exercised on a subjective level by orienting the political community toward the temporary annihilation of both the subject and the Symbolic in divine love. The article concludes by contending that the positioning of the Godhead as master signifier for the prefigurative postanarchist political community can contribute to the reenchantment of the world by forming part of a broader, nascent Symbolic, constituted through the production of a range of master signifiers reflective of a variety of largely heterogenous political communities configured around broadly nonhierarchical, spiritual values and connected via a logic of affinity.
Loss and the Production of Community Archives
Authors: Drummond Molly 
Published: September 2024

Abstract
This visual essay concerns the generative capacities of loss in the production and maintenance of community archives and archiving communities. In archival sites, the loss of space through the collection of items, as well as degradation and wear and tear, is a concern that traditional archival practice seeks to address, manage, and mitigate. However, through the discussion of two case studies—a participatory arts company in Stoke on Trent and zine archives and libraries in Manchester and Birmingham—loss can materialize as presence, through damp and clutter, evidence of community activity, and debate and discussion. Furthermore, the author argues that loss is generative of archives themselves by drawing from the ongoing work in the two sites, as well as the emergence of archival practice and debates specific to the communities themselves.