bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiogenic shock in general intensive care unit: a nationwide prospective analysis of epidemiology and outcome
Authors: Guido Tavazzi , Giovanni Tricella , Elena Garbero , Anna Zamperoni , Michele Zanetti , Stefano Finazzi 
Published: September 2024

Abstract

Aims
Cardiogenic shock (CS) is a life-threatening disease burdened by a mortality up to 50%. The epidemiology has changed with non-ischaemic aetiologies being predominant, although data were mainly derived from patients admitted to dedicated acute cardiac care. We report the epidemiology and outcome of patients with CS admitted to general intensive care unit (ICU).

Methods and results
Prospective multicentric epidemiological study including 314 general ICU adhering to the GiViTI nationwide registry from 2011 to 2018, excluding cardiac arrest. The primary endpoint of the study was mortality. The association between clinical factors and mortality was evaluated using a logistic regression model. The odds ratios (ORs) of the covariates quantify their association with mortality during hospitalization. A total of 11 052 patients admitted to general ICU {incidence 2.17%; median age 72 [interquartile range (66–81)], 38.7% were women} with CS were included. Forty-seven per cent of patients had more than three organ insufficiency at the time of admission. The most common CS aetiologies were left heart failure (LHF, 5247—47.5%); acute myocardial infarction (3612—32.6%); right heart failure (RHF, 515—4.6%); and biventricular failure (532—4.8%). A total of 85.5% were mechanically ventilated during the ICU hospitalization. The overall ICU mortality was 44.8%, increasing to 53.4% during the hospitalization in the index hospital and to 54.3% at the latest hospital. Right heart failure–cardiogenic shock patients exhibited the highest mortality risk [OR: 1.19, 95% confidence interval (CI) (0.94–1.50); P &lt; 0.001], followed by biventricular CS [OR 1.04, 95% CI (0.82–1.32)]. Respiratory failure [OR 1.13 (95% CI 1.08–1.19)], coagulation disorder [1.17 (95% CI 1.1–1.24)], renal dysfunction [OR 1.55 (95% CI 1.50–1.61)], and neurological alteration [OR 1.45 (95% CI 1.39–1.50)] were associated with worsen outcome along with severe hypotension [systolic blood pressure &lt; 70 mmHg—OR 2.35, 95% CI (2.06–2.67)], increasing age [OR 2.21 95% CI (2.01–2.42)], and longer ICU stay prior to admission (two-fold increase for each 4.7 days).

Conclusion
In the general ICU, the aetiology of CS, excluding cardiac arrest, remains characterized mostly by LHF with RHF–CS burdened by higher mortality. Multiorgan failure at admission and longer hospital stay before ICU admission predispose to worsen outcome.
Real-world evaluation of multimodal treatment practice in older oesophageal cancer patients
Authors: Shen Tianzheng , Zhang Yajie , Cao Yuqin , Zhang Jie , Li Hecheng 
Published: September 2024

Abstract

OBJECTIVES
Elderly-specific data for multimodal treatment of oesophageal cancer (EC) is lacking. This study aimed to evaluate the safety and efficacy of multimodal treatment in older EC patients and to compare the impact of neoadjuvant chemotherapy (NCT) and neoadjuvant chemoradiotherapy (NCRT).

METHODS
Patients diagnosed with oesophageal squamous cell carcinoma or adenocarcinoma who received NCT/NCRT were identified in the National Cancer Database (NCDB, 2004–2015). First, we compared baseline and post-treatment characteristics between younger (&lt;70 years) and older patients (≥70 years). Logistic regression was used to investigate risk factors of postoperative mortality. Second, we evaluated the effect of neoadjuvant chemotherapy on postoperative mortality and overall survival in the older cohort. Inverse probability of treatment weights and multivariable analyses were used to compensate for differences in baseline covariates.

RESULTS
We 1st compared outcomes of neoadjuvant therapy plus oesophagectomy in 14 778 eligible EC patients. The older group experienced higher rates of postoperative mortality at 30 days (5.8%) and 90 days (13.5%) compared to younger patients. Postoperative mortality was significantly related to the Charlson–Deyo score and treatment-related factors including neoadjuvant therapy type and minimally invasive technique. Second, among the 3141 older patients (with a median follow-up of 57.8 months and 2029 deaths), those receiving NCT obtained significantly lower postoperative mortality and improved overall survival compared with NCRT (inverse probability of treatment weights-adjusted P = 0.05; hazard ratio 0.85; 95% Cl 0.72–0.99).

CONCLUSIONS
Neoadjuvant therapy plus oesophagectomy carries increased short-term mortality risk in older EC patients. NCT in older EC patients showed lower postoperative mortality but no statistically significant differences in overall survival, with a point estimate favouring NCT compared to the NCRT group, making NCT a potential option for consideration in specific cases.
Interviewing people on sensitive topics: challenges and strategies
Authors: Westland Heleen , Vervoort Sigrid , Kars Marijke , Jaarsma Tiny 
Published: September 2024

Abstract
Interviewing participants on sensitive topics is challenging and requires carefully planned and executed strategies throughout the research process. Sensitive topics have the potential to cause distress to participants or researchers. In this methods paper, strategies for conducting interviews on sensitive topics are described, including choosing the appropriate interview approach, creating a safe and comfortable environment, building rapport, utilizing sensitive and open questioning, reflexivity of the researcher, and awareness of the potential therapeutic effect of the interviews on participants. The strategies are illustrated with experiences from research on sensitive topics.
Clinical effects of accreditation in general practice: a pragmatic randomized controlled study
Authors: Pedersen Line B , Andersen Merethe K , Wehberg Sonja , Siersma Volkert , Søndergaard Jens , Kousgaard Marius B , Due Tina D , Reventlow Susanne , Bro Flemming , Waldorff Frans B 
Published: September 2024

Abstract

Background
Accreditation has been implemented in general practice in many countries as a tool for quality improvement. Evidence of the effects of accreditation is, however, lacking.

Aim
To investigate the clinical effects of accreditation in general practice.

Design and setting
A mandatory national accreditation programme in Danish general practice was rolled out from 2016 to 2018. General practices were randomized to year of accreditation at the municipality level.

Methods
We conducted a pragmatic randomized controlled study with general practices randomized to accreditation in 2016 (intervention group) and 2018 (control group). Data on patients enlisted with these practices were collected at baseline in 2014 (before randomization) and at follow-up in 2017. We use linear and logistic regression models to compare differences in changes in outcomes from baseline to follow-up between the intervention and control groups. The primary outcome was the number of redeemed medications. Secondary outcomes were polypharmacy, nonsteroidal anti-inflammatory drugs (NSAIDs) without proton pump inhibitors, sleeping medicine, preventive home visits, annual controls, spirometry tests, and mortality.

Results
We found statistically significant effects of accreditation on the primary outcome, the number of redeemed medications, and the secondary outcome, polypharmacy. No other effects were detected.

Conclusion
In this first randomized study exploring the effects of accreditation in a primary care context, accreditation was found to reduce the number of redeemed medications and polypharmacy. We conclude that accreditation can be effective in changing behaviour, but the identified effects are small and limited to certain outcomes. Evaluations on the cost-effectiveness of accreditation are therefore warranted.
Spillover and competitive exclusion in the crustacean community following the implementation of a marine reserve
Authors: Amelot Morgane , Normand Julien , Schlaich Ivan , Ernande Bruno 
Published: September 2024

Abstract
Flamanville marine protected area (MPA) located in Normandy, France, was created in 2000 to sustain the local crustacean fishery. In 1985, an annual survey targeting crustacean populations (e.g. European lobster Homarus gammarus, edible crab Cancer pagurus, and European spider crab Maja brachydactyla) that include the future MPA started. The MPA implementation effects were investigated in this study. The sampling design allowed the integration of spatial and temporal covariances to estimate the MPA effects. With respect to the initial objective, the MPA significantly improves the most economically valuable species, H. gammarus, abundance. Lobster catch per unit effort increased by 597% in the MPA, whereas outside it only increased by 156%. The MPA creation also led to an increase in lobster size inside the protected area. Furthermore, a few years after the MPA implementation, lobster catches showed a significant non-linear decline with distance from the centre of the reserve, suggesting a spillover effect. However, the edible crab catches were halved following the MPA implementation suggesting an opposite effect. Spider crab abundance seemed unaffected. Finally, the MPA implementation had no effect on edible crab and spider crab sizes. These differential responses appear to result from these species’ variable movement and competitive abilities.
Carbon footprint of expressway bridges based on LCA
Authors: Cao Jian , Wang Danshen , Han Ziyang , Li Shengwei , Zhao Hong , Liu Xu 
Published: September 2024

Abstract
Based on the whole life cycle theory, the research stage of an expressway bridge is divided into six stages: preliminary preparation design stage, production and processing stage of bridge structural materials, transportation stage of materials, on-site construction stage, operation stage and waste recycling stage, and the calculation model of expressway bridge carbon footprint is constructed. Two bridges along the Pingxiang Expressway in Jiangxi Province were chosen as case studies. Their carbon emissions across the entire life cycle were computed using the bill of quantities. Findings indicate that the material production stage accounts for the highest proportion of carbon emissions throughout the life cycle, whereas the construction stage registers the lowest proportion. Lastly, the results are compared with existing research to validate the feasibility and accuracy of the calculation model.
Application research of deep learning-based BIM Technology in Intelligent Construction
Authors: Tao Liang , Zou Leirong , Gao Zhaohong 
Published: September 2024

Abstract
With the increasing importance of energy-efficient renovations in architecture, the pressing issue of how to enhance the effectiveness of such renovations through advanced technology has come to the forefront. This article affirms the significance of building information modeling (BIM) technology in energy consumption renovations. It introduces a BIM-based building energy monitoring system, which not only provides comprehensive and effective static information for energy consumption analysis but also offers real-time visualization of energy consumption status for daily management. By collecting all necessary data for energy management and storing it in the cloud, this system greatly facilitates data analysis. Moreover, the article proposes a short-term electricity load forecasting method for community buildings based on empirical mode decomposition (EMD)-gated recurrent unit (GRU). The EMD-GRU method proposed in this article exhibits superior accuracy compared to other methods, with a mean absolute percentage error value of 14.43%. By considering factors such as historical load, weather, and date, this method accurately predicts short-term electricity loads for communities. This research provides a robust framework for improving energy management in buildings through advanced technologies, ultimately leading to more effective energy-saving renovations and optimizations.
Evolving strategies in microbe identification—a comprehensive review of biochemical, MALDI-TOF MS and molecular testing methods
Authors: Arbefeville Sophie S , Timbrook Tristan T , Garner Cherilyn D 
Published: September 2024

Abstract
Detection and identification of microorganisms are the first steps to guide susceptibility testing and enable clinicians to confirm diseases and guide therapy. The faster the pathogen identification is determined, the quicker the appropriate treatment can be started. In the clinical microbiology laboratory, multiple methodologies can be used to identify organisms, such as traditional biochemical testing or more recent methods like MALDI TOF MS and nucleic acid detection/identification assays. Each of these techniques has advantages and limitations, and clinical laboratories need to determine which methodology is best suited to their particular setting in terms of clinical needs, availability of technical expertise and cost. This article presents a concise review of the history, utilization, advantages and limitations of the main methods used for identifying microorganisms in microbiology laboratories.
Barriers to implementation of rapid identification and antimicrobial susceptibility testing technologies in the clinical microbiology laboratory: an American perspective
Authors: Simons Corrie C , Capraro Gerald A 
Published: September 2024

Abstract
Clinical microbiology laboratories are responsible for confirming the aetiology of infectious diseases and providing antimicrobial susceptibility testing results. Traditional culture-based testing can be augmented by more rapid testing modalities to provide clinically actionable information as quickly as possible. Despite improvements in patient outcomes, many clinical microbiology laboratories are facing challenges to in-sourcing these technologies. Depending on a multitude of factors, including size, location and patient population served, these barriers may affect some laboratories and hospital systems to greater or lesser extents than others. It will be up to each individual facility to ascertain its ability to overcome barriers. To aid in this self-assessment, we present for thoughtful consideration a discussion of the barriers to implementation of rapid identification and antimicrobial susceptibility testing technologies, with specific attention to matters of financial cost, staff expertise, operational issues and stakeholder buy-in.
The United Nations’ General Assembly High-Level Meeting on antimicrobial resistance: a joint statement from the Heads of Government and Chief Medical Officers of the United Kingdom’s Overseas Territories
Authors: Dryden Matthew , Corley Michael , Wright Natalie , Andrewin Aisha , Georges Ronald , Ramroop Shaun , Greenaway Sharra , Gent Nicholas , Astwood Nadia , Hardy William , Carter Helen , Moss Peter , Edwards Rebecca , Wonner Alex , Oyinloye Ayo , Donovan Kevin 
Published: September 2024

Abstract
The UK Overseas Territories (UKOTs) are small, often remote territories with historical and territorial links to the UK. They range from densely populated areas (Cayman, Bermuda, Gibraltar) to land with no permanent inhabitants (British Antarctic Territory, South Georgia). However, they are linked by ecosystem instability (the permacrisis) including antimicrobial resistance (AMR), climate change and biodiversity disruption. The Chief Medical Officers of the UKOTs met in June 2024 and were unanimous in their concerns about the threat of global AMR. They have issued this statement on their hopes and expectations for the United Nations’ General Assembly High-Level Meeting, in September 2024. These may be summarized by the hope of achieving united and sustained global political will to reduce the threat of AMR by equitable access to treatments, prevention of AMR by sanitation and accurate diagnostics, and education in health care and the public.
Japan’s cancer survivorship guidelines for exercise and physical activity
Authors: Tsuji Katsunori , Sasai Hiroyuki , Kiyohara Kosuke , Nakata Yoshio , Nishiwaki Hiroki , Ohta Takahisa , Ochi Eisuke , Takano Toshimi , Tatematsu Noriatsu , Matsuoka Yutaka J 
Published: September 2024

Abstract

Objective
This research aimed to establish the inaugural evidence-based cancer survivorship guidelines for Japan, with a particular focus on exercise and physical activity, in order to enhance health outcomes for cancer survivors.

Methods
A panel of experts, including oncologists, physicians, exercise scientists, epidemiologists and patient advocates, utilized a modified Delphi process and systematic reviews to establish consensus on exercise recommendations for cancer survivors. The panel focused on setting the objectives of the Clinical Practice Guidelines and addressing crucial clinical issues in Japan. Recommendations were formulated based on the strength and certainty of evidence, the benefit–harm balance and patient values and preferences.

Results
The panel formulated exercise recommendations for cancer survivors of two age groups: 18–64 years and ≥65 years. The recommendations for both age groups are consistent, emphasizing the importance of regular exercise and physical activity tailored to individual capabilities and health conditions. The guidelines underline the benefits of exercise in improving the overall health and quality of life of cancer survivors. This consensus on exercise recommendations marks a significant step in the development of comprehensive cancer survivorship guidelines in Japan, with potential implications for improving clinical outcomes and advancing research in cancer survivorship.

Conclusions
These guidelines will serve as a critical resource for cancer survivors, highlighting exercise as a key component of survivorship care, and for clinicians, in recommending appropriate physical activities to improve survivor health and well-being.
A longitudinal test of relational turbulence theory and serial arguments in romantic relationships
Authors: Solomon Denise Haunani , Li Yuwei , Brisini Kellie StCyr , Vanderbilt Rachel Reymann 
Published: September 2024

Abstract
Relational turbulence theory (RTT) suggests that people perceive their romantic relationships as turbulent when they experience interactions that manifest the deleterious effects of relational uncertainty and altered patterns of interdependence. RTT also positions communication in these episodes as associated with subsequent relational uncertainty and qualities of interdependence. Using three-wave panel data collected at three-week intervals, this study evaluates (a) how communication in serial argument episodes predict relationship parameters (i.e., relational uncertainty and qualities of interdependence), (b) how relationship parameters predict serial argument occurrence, directness, and valence, and (c) whether over time variability in qualities of serial argument communication predict subsequent relational turbulence. Results indicated limited support for reciprocal, between-wave associations between relationship qualities and serial argument communication; however, over time variability in the valence of serial argument communication was associated with higher levels of relational turbulence after 6 weeks. Implications for RTT and research on serial arguments are discussed.
Inflation of crisis coverage? Tracking and explaining the changes in crisis labeling and crisis news wave salience 1785–2020
Authors: Geiß Stefan , Viehmann Christina , Kelly Conor A 
Published: September 2024

Abstract
Has there been an inflation in crisis coverage in newspapers over the last centuries, and if so, what structural factors drive this change? We utilize computational text analyses along with our own signal detection algorithm to measure the presence of crisis keywords and the emergence of crisis news waves. An analysis of crisis coverage in The Times (U.K., 1785–2020, 183,239 news stories) shows that the share of coverage that uses crisis keywords has increased, though not steadily. The number and salience of crisis news waves tied to discernible events has increased at a slower pace. The hypothesized driving forces—government expansion, mediatization of politics, and the activity of crisis frame sponsors—explain the development well and allow accurate predictions even when ignoring time in the forecasting model. Crisis coverage seems to reflect not so much the problems society faces, but society’s identity, priorities, and outlook on the world.
Kinematic study of the Orion Complex: analysing the young stellar clusters from big and small structures
Authors: Sánchez-Sanjuán Sergio , Hernández Jesús , Pérez-Villegas Ángeles , Román-Zúñiga Carlos , Aguilar Luis , Ballesteros-Paredes Javier , Bonilla-Barroso Andrea 
Published: September 2024

ABSTRACT
In this work, we analysed young stellar clusters with spatial and kinematic coherence in the Orion star-forming complex. For this study, we selected a sample of pre-main-sequence candidates using parallaxes, proper motions, and positions on the colour–magnitude diagram. After applying a hierarchical clustering algorithm in the 5D parameter space provided by Gaia DR3, we divided the recovered clusters into two regimes: Big Structures and Small Structures, defined by the number of detected stars per cluster. In the first regime, we found 13 stellar groups distributed along the declination axis in the regions where there is a high density of stars. In the second regime, we recovered 34 clusters classified into two types: 14 as small groups completely independent from the larger structures, including four candidates of new clusters, and 12 classified as sub-structures embedded within 5 larger clusters. Additionally, radial velocity data from APOGEE-2 and GALAH DR3 was included to study the phase space in some regions of the Orion Complex. From the Big Structure regime, we found evidence of a general expansion in the Orion OB1 association over a common centre, giving a clue about the dynamical effects the region is undergoing. Likewise, in the Small Structure regime, the projected kinematics shows the ballistic expansion in the $\lambda$ Orionis association and the detection of likely events of clusters’ close encounters in the OB1 association.
The Audience Chimera: On Platforms, Publics, and Power
Authors: Arnold Cory 
Published: September 2024

Abstract
A central question in recent scholarship on public music theory has been understanding its purpose and its relationship to traditional academic theory. However, one recurring weakness of these sorts of analyses is a tendency to view public music theory as a monolithic entity with a coherent identity and a singular purpose. In this paper, I argue that public music theory is better viewed as a decentralized collection of individual actors and communities whose actions must be understood in reference to the specific audiences they serve and the specific platforms through which they distribute their work, rather than to each other or to the academic world. I explore the power structures that shape the goals (and membership) of these various communities as they relate to their various publics, and I develop a framework to describe the flow of consumptive power in order to explain the observable differences between most forms of public music theory and the academic discipline they represent.
Andrea Cornaro’s World
Authors: Barber Charles 
Published: September 2024

Abstract
Chapter 1, “Andrea Cornaro’s World,” introduces the reader to the culture of late sixteenth-century Crete through the will of a leading Veneto-Cretan aristocrat. Engaging more fully with the unique context of the island may help to approach Cretan painting in a manner that is open to its particular dynamism and less fettered by presumptive and nostalgic categories. The chapter discusses Cornaro’s funerary rites, his possessions, and his intellectual network. The island’s complex colonial society, with its Venetian and Greek aspects, is described. Particular attention is paid to the intellectual climate of elite society. Responses to the threat of invasion by the Ottoman Turks are also discussed.