bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation and Evaluation of Buccoadhesive Drug Delivery System for Lovastatin
Authors: THENGE RAJU RAMESH , Mahajan S. S. , Mahajan N. M. , Adhao V.S. , Ajmire P. V. 
Published: September 2024

Lovastatin, a hyperlipedemic agent used in the treatment of hypercholesterolemia, has poor bioavailability ( less than 5%) due to the first pass metabolism and thus the dosing frequency is more, as a result of which several side effects occurred with the current dosage form. The present study aimed to formulate and evaluate buccoadhesive tablets of Lovastatin using mucoadhesive polymer such as Carbopol 934P, Hydroxypropylmethyl cellulose (K4M, K100M) and sodium CMC. The different formulations of buccoadhesive tablet of Lovastatin were prepared by direct compression method and characterized for physicochemical parameters such as thickness, content uniformity, weight variation, hardness, and friability test. The swelling index, % matrix erosion, surface pH, bioadhesive strength, bioadhesive time and in-vitro drug release are also carried out which has been important aspect for success of buccoadhesive tablets. The FTIR study was carried out for drug and polymer compatibility. All the formulation showed satisfactory tablet properties. Formulation (F5) containing Carbopol 934P and HPMC K4M in the ratio of (1:1) showed good bioadhesive strength and maximum drug release of 95.80% in 8 hours. The surface pH of all tablets was found to be satisfactory, close to buccal pH, hence no irritation would observe with these tablets. FTIR studies showed no evidence of interaction between drug and polymers.
Keywords: Buccoadhesive tablets, Lovastatin, FTIR, Carbopol 934P, in-vitro drug release
Comparative analysis of some commonly consumed allergic food materials
Authors: PAUL MOUMITA , BAG SUBARNA , DUTTAGUPTA SOUMILI , Bhattacharya Malavika 
Published: September 2024

Abstract
Background
Food allergy is turning out to be one of the vital causes of death in all countries irrespective of the socio-economic status of the people. The extent of mortality from food allergens has increased several folds in the last decade. This has brought research on food allergy and its causative properties to the front. Human beings have the natural power to fight with an allergen, ranging from viruses to food. But in the case of immune-compromise or some other defects in the immune system, individuals can react against some food allergic component(s). Various studies have indicated that cereal or grain particles are more allergic materials than fruits or vegetables.

Objective
This study was carried out with the main objective of understanding the variations in various biochemical parameters of a few foods commonly consumed and known to elicit allergic reactions.

Methods
In this study, a few food materials known to elicit allergic reactions in some individuals were selected and comparative analysis (qualitative and quantitative) was performed in an attempt to understand the basis of their differential responses.

Results
The studies indicated difference in various biochemical parameters and anti-oxidative properties between equivalent quantities of the food samples.

Conclusion
Our study has revealed differential levels of nutrient contents and anti-oxidative properties between equivalent quantities of the samples of allergic food materials. These findings can be used for further research on the underlying mechanisms of their action.
Keywords: Food allergy, Biochemical attributes, Non-communicable diseases, Dietary habits, Nutrition
Ayurveda and Modern Correlation of Some Infectious Diseases: A Literary Review
Authors: Jain Ashutosh Kumar , Jain Jinesh Kumar , Diwedi O. P. 
Published: September 2024

Charak the ancient Acharya of traditional medical practice described Doshavikriti and Agantuj as major factors responsible for disease prevalence. Doshavikriti is internal factors related to Dosha vitiation and Agantuj is external factor which involve role of contaminated water, food, microbes and trauma in diseases occurrence. Ayurveda text mentioned Kustha , Jwara, Shosha and Netrabhishyanda as diseases which spreads one to another through direct or indirect contact. The Prasnaga, Gatra Sansparsha, eating & sleeping together, sharing cloths & ornaments are some mode of transmission of infectious diseases. There are significant correlations between ayurveda and modern literature available on infectious diseases. However some descriptions on specific diseases mentioned in ayurveda text differ from modern text up to some extent. Therefore it is required to present modern and ayurveda aspects of infectious diseases, considering same present article summarizes correlation between ayurveda and modern text on some infectious diseases.
Keywords: Ayurveda, Infectious Diseases, Contagious Diseases, Microorganism, Krimi.
New spectrophotometric techniques for the estimation of osimertinib mesylate in tablet dosage form
Authors: Talluri Chakradhar , Mondal Sumanta , Biswal Sabyasachi 
Published: September 2024

Osimertinib Mesylate is used for a treatment of non small cell lung cancer (NSCLC). Whereas only few simple, precise and accurate spectrophotometric methods were developed for the determination of Osimertinib Mesylate (tagrisso) in pharmaceutical dosage forms. The absorption maxima was found to be at 267 nm in method A (0.1N HCl) and shows linearity over the concentration range of 0.002-0.02 µg/mL with regression equation y=0.4323x + 0.0104 (r2 = 0.9992). In Method B (Sodium acetate buffer, pH 4.5) the drug obeys Beer Lambert’s law (λmax267nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.484x-0.017(r2= 0.9992). In Method C (phosphate buffer, pH 7.2) the drug obeys Beer Lambert’s law (λmax267nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.2949x+0.0108(r2= 0.9992) In Method D (Methanol ) the drug obeys Beer Lambert’s law (λmax267nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.6323x+0.003 (r2= 0.999). 1st derivative spectrophotometric method (E, F, G and H) were developed in 0.1NHCl and Sodium acetate pH 4.5 and phosphate buffer pH 7.2 and methanol in which Osimertinib Mesylate obeys Beer Lambert’s law 0.002-0.02 µg/mL and 0.002-0.02 µg/mL and 0.002-0.02 µg/mL and 0.002-0.02 µg/mL with regression equations y=0.0259x + 0.0008 and y=0.0137x - 0.0005 and y=0.0097x-0.0008 and y=0.0087-0.0007 respectively. The proposed spectrophotometric method was validated as per the ICH guidelines and can be applied for the determination of Osimertinib Mesylate in pharmaceutical formulations. Osimertinib Mesylate, Derivative spectroscopy, Spectrophometry, Validation, Tagrisso.
Keywords: Tagrisso, Osimertinib Mesylate, Derivative spectroscopy, Spectrophometry, Validation.
Ayurvedic management of Idiopathic Thrombocytopenic Purpura - A Case Study
Authors: Agrawal Dr. Shriti , Bhakuni Harish , Joshi Ram Kishor 
Published: September 2024

Idiopathic thrombocytopenic purpura is characterised by immunologic destruction of platelets and normal or increased megakaryocytes in the bone marrow. On the basis of clinical presentation , Idiopathic thrombocytopenic purpura is classified into acute and chronic forms in which severe bleeding, or insidious with slow development with mild or no symptoms occcurs. According to Ayurvedic classics ITP can be correlated with Tiryaga Raktapitta as in this disease all the Dosas are vitiated and are circulating in the blood stream and manifested subcutaneously. The present case study was dealt with, the chronic form of disease, to check the bleeding and to stop the destruction of platelets. In this case an effort was made to treat a 35 years old female patient having symptoms - blackish patches in forehead and in both lower legs, bleeding from nose and excessive bleeding during menses since 3 years treated with Giloya and Durwa swarasa, Ojaswani churna, Shatavari Churna, Akik Pishti, Shudha Sphatika and Aamlaki Churna in BD dose in combination with normal water in oral form for 7 months. After 7 months of treatment patient got much improvement in symptoms with increase in platelets counts.
Liposomes encapsulating cyclodextrin enclosed hydrophobic anti-cancer drugs: a novel drug delivery system for cancer.
Authors: Jani Dr. Rupalben Kaushalkumar , Pandya Mansi , Rathod Hemali 
Published: September 2024

In the current situation in the health care industry is to face many challenges to cure the cancer. The second highest death were noticed by the cancer in society. Therefore, the efficient treatment is required. There many treatmentsare available to cure the cancer but not found much efficient. The advance development in the hydrophobic drug in the form of water-soluble drug cyclodextrin complex in liposomes has been investigated. This new investigation in to the complex in liposomes play key role in combination of the cyclodextrin and liposomes in the one common system. Such system would potentially increase the drug to lipid mass ratio. In comparison to conventional treatment this ratio is high therefore it enlarges the range of insoluble drug amenable to encapsulation to include, allow targeting, of complexes to specific sites and reduce toxicity, for instance and membrane destabilizing agents. This extensive review explores the novel drug delivery for the cancer treatment.
Keywords: Liposomes, cyclodextrin, anti-cancer, novel drug delivery system
Evaluation of the poly herbal drug: Keelvayu Nivarana Churnam
Authors: G Vijayabaskar , V ELANGO 
Published: September 2024

Siddha Medicine is regaining its lost glory throughout the World. For the universal acceptations of Siddha medicine we should standardize by scientific validation at various levels. Herbals have been an important source of medicine with qualities for thousands of years. Phytochemicals are the active principles of the herbal drug. Keelvayu nivarana churnam is one of the poly herbal drugs used for Arthritis. In this study we carried out powder microscopy for identification of the ingredient medicinal plants. We studied Physicochemical parameters like appearance, pH, total ash, loss on drying; water soluble extractive, alcohol soluble extractive, bulk density and tap density are evaluated. In Phyotochemical screening the presence or absence of alkaloids, flavanoides, tannins, proteins, sterols, carbohydrates, glycosides, terpenoides, saponins and starch. We did Gas chromatography and Mass spectroscopy (GC-MS/MS) for the identification of bioactive compounds of Keelvayu nivarana churnam. These findings support the therapeutic value of Keelvayu nivarana churnam in Arthritis.
Keywords: Arthritis; Keelvayu nivarana churnam; Powder Microscopy; Physicochemistry and Phytochemistry; Gas chromatography–mass spectrometry (GC-MS/MS).
THE Formulation and In-vitro evaluation of press coated tablets of pravastatin for pulsatile drug delivery
Authors: PRIYA PITTU VISHNU , Sharma JVC , Archana G. , Arshi Hasan , Singh M. Arjun , Nikhila V. 
Published: September 2024

The aim of present study is to formulate and evaluate Pravastatin pulsatile drug delivery system by press coated method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 hrs. The basic design of the system consists of a rapid release core and controlled release coat. Core blend was evaluated for flow properties, hardness, thickness, friability and invitro drug release. Invitro drug release studies of press coated tablets for various formulations i.e., P1F6-P5F6 was conducted. From the results obtained by executed trails P5F6 of coated tablet containing 50% of ethyl cellulose and 20% of HPMC K15M concentration shows lag time up to 6hr and followed by complete drug release at the end of 8hr. Among these, P5F6 was considered as optimized formulation based on the lag time and percent of drug release (98.96% of drug release in 6 hrs). So, it is selected as optimized formulations for designing pulsatile device.
Keywords: Pravastatin, SSG, lycoat, ethyl cellulose, HPMC K15M, pulsatile drug delivery, Press coated method.
New spectrophotometric techniques for the estimation of Perphenazine in bulk drug form
Authors: Mondal Sumanta , Rohith Kumar Chekka , Sai Pavan T , Sampath K , Vanapalli Goutham Kumar 
Published: September 2024

Perphenazine is an atypical antipsychotic drug. The simple and accurate and precise absorption ratio method has been developed for the simultaneous estimation of Perphenazine in the pure drug form. The absorption maxima were found to be 310nm in Method A (0.1N HCl Buffer) and show linearity over the concentration range of 0.002-0.02 µg/mL with regression equation y=0.5372x-0.0099(r2 = 0.9990). In Method B (Sodium acetate buffer, pH 4.5) the drug obeys Beer Lambert’s law (λmax 310nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.4257x - 0.0084(r2= 0.9992). In Method C (Phosphate buffer, pH 6.8) the drug obeys Beer Lambert’s law (λmax 310nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.482x - 0.0074(r2= 0.9991). In Method D (phosphate buffer, pH 7.2) the drug obeys Beer Lambert’s law (λmax 310nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.3686x - 0.0055(r2= 0.9992). In Method E (0.1N NaOH Buffer) and shows linearity over the concentration range of 0.002-0.02 µg/mL with regression equation y=0.4864x-0.0081(r2 = 0.999). In Method F (Methanol) the drug obeys Beer Lambert’s law (λmax 300nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.6323x - 0.003(r2= 0.999). In Method G (Ethanol ) the drug obeys Beer Lambert’s law (λmax 300nm) in the concentration range of 0.002-0.02 µg/mL with regression equation y=0.3686x - 0.0055(r2= 0.9991). First derivative spectrophotometric methods (A1, B1, C1, D1, E1, F1 and G1) were developed in 0.1NHCl and Sodium acetate pH 4.5 and phosphate buffer, in pH 6.8 and phosphate buffer, pH 7.2, 0.1N NaOH Buffer, which Perphenazine obeys Beer Lambert’s law(λmax310nm) in the concentration range of 0.002-0.02 µg/mL and 0.002-0.02 µg/mL and 0.002-0.02 µg/mL and 0.002-0.02 µg/mL and0.002-0.02 µg/mL with regression equations y=0.0357x - 0.0006 and y=0.0201x+0.0004 and y=0.0196x-0.0002 and y=0.0162x+0.0002 and y=0.0239x - 0.0002 and Perphenazine obeys Beer Lambert’s law(λmax300nm) for methanol and ethanol in the concentration range of 0.002-0.02 µg/mL and 0.002-0.02 µg/mL with regression equations y=0.0423x-0.0003 and y=0.0371x+0.0003 respectively.
Isolation and Screening of Actinomycetes producing Antibacterial compounds from different river sediments
Authors: Abbas Sahil , Gautam Girendra , Gautam Pawan Kumar 
Published: September 2024

The history of antibacterial begins with the observations of Pasteur and Joubert, who discovered that one type of bacteria could prevent the growth of another. They did not know at that time that the reason one bacterium failed to grow was that the other bacterium was producing an antibiotic. Of course, in today's common usage, the term antibiotic is used to refer to almost any drug that attempts to rid your body of a bacterial infection. The past researches indicated that huge number of antibiotics was produced by Gram +ve ike bacteria known as Actinomycetes. So we can say that among all microbes more than 50% of the known antimicrobial compounds were produced by Actinomycetes only. In our study isolation and screening of Actinomycetes was performed by using different river sediments. Soil samples was collected from river Godaveri and Krishna and stored in the U.V. and alcohol sterilized Poly bags. Soil samples was serially diluted up to 10-6 and 1 ml from each dilution was plated on different isolation media like starch Casein agar, Albumin media and YMA media, consisting of antifungal agent Nystatin 50 µg/ ml, by pour plate technique. The plates were incubated at different temperature ranges 18 0C to 28 0C upto 7-14 days. Determination of antibacterial activities of pure actinomycetes cultures of S1, S2, S3 and S4 were performed by using streak -plate method. Mueller hinton agar plates will prepared and inoculated with actinomycetes cultures by a single streak of inoculums in the center of the Petri dish and will incubated at 270C for 4 days. Later, the plates will seeded with test organisms by a single streak at a 900 angle to actinomycetes strains. Antagonism was measured by the determination of the size of the inhibition zone. The antibacterial activity of compound was tested against different gram +ve and Gram –ve by the standard disc diffusion method and cup plate method. Standard streptomycin was used for comparison of the antibacterial activity.
Pharmacognostical and Phytophysicochemical investigations of Trigonella foenum – graecum Linn
Authors: Thorat R. M. , Gaikwad D.D. 
Published: September 2024

Fenugreek (Trigonella foenum-graecum L.), plant is distributed throughout the world and which belongs to the family Fabacecae. The fenugreek seed contains active constituents such as Carbohydrates, Proteins, Alkaloids, Flavonoids, Free amino acids, Saponins, Glycosides, Vitamins, Minerals, Mucilage, Fixed Oils & Volatile Oils etc. It has been commonly used as a traditional food and medicine. Fenugreek is known to have hypoglycemic, and hypocholesterolaemic effects, Anti-inflammatory effects. Fenugreek has potential for curing diseases and also as a source for preparing raw materials of pharmaceutical industry like in steroidal hormones. This review gives view mainly on the Morphological evaluation, Microscopic evaluation, Physicochemical evaluation, Fluorescence Analysis and Phytochemical evaluation.
Keywords: Trigonella Foenum-groecum L., Seeds, Fabacecae, Saponins.
Development and validation of RP-HPLC method for simultaneous estimation of metformin hydrochloride and glipizide in bulk and pharmaceutical dosage form
Authors: Bagadane Snehal Bapusaheb , Jadhav Prerana B. 
Published: September 2024

A simple, accurate, economical and precise reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for simultaneous estimation of Metformin hydrochloride and Glipizide in bulk and pharmaceutical dosage form. The separation of Metformin hydrochloride and Glipizide was achieved by using Cosmosil C 18 (250 mm × 4.6 ID, particle size-5 micron) column as stationary phase with the mobile phase comprising of methanol and water (60:40 ,pH 3 adjusted with ortho-phosphoric acid) in an isocratic mode and flow rate of 0.8 ml/min with UV detection at 226 nm. The retention time of Metformin hydrochloride and Glipizide were found to be 4.159 min and 5.571 min respectively. The proposed method was validated according to ICH guidelines for the parameters like linearity, accuracy, precision, percent recovery, robustness, ruggedness, limit of detection and limit of quantitation. The % RSD is found to be less than 2 % and the tailing factor for both the drugs are found to be less than 2. The number of therotical plates for Metformin hydrochloride and Glipizide were found to be more than 2000.All validation parameters were within the acceptable range. The developed method was successfully applied for the estimation of Metformin hydrochloride and Glipizide in bulk and pharmaceutical dosage forms.
Keywords: Metformin hydrochloride, Glipizide, RP-HPLC, Validation, Simultaneous estimation, ICH guidelines.
Drug Utilization Study and Adverse Drug Reaction Reporting among Patients Using Anticoagulants in a Tertiary Care Teaching Hospital
Authors: Alzubaidi Nafaa , Sharma Manju , Abdulmalik Watheeq , Habib Anwar , Alhalmi Abdulsalam 
Published: September 2024

Drug utilization (DU) is systematic regulatory approach designed to identify diversity of drugs use and to evaluate the rational use of medicines in population. Anticoagulants are drugs used to avoid thrombus extension and embolic consequences with associated risks related to their administration. Objectives: The objectives of the present study were to evaluate the drug prescription pattern of anticoagulants, observe and report drug interactions and adverse drug reactions among patients using anticoagulants. Method: Utilization of anticoagulant drugs was evaluated in 50 patients from 4 wards (dialysis, medicine, orthopedic and intensive-care unit) of a tertiary care teaching hospital in a cross-sectional, prospective study conducted for 4 months i.e. from 1st January 2018 to 30th April 2018. Results: LMWH (enoxaparin) was the maximum preferred parenteral anticoagulant prescribed to 31 % of patients as prophylaxis for deep vein thrombosis followed by heparin. 14(28%) of total population were administered combination therapy and 36 (72%) patients received only one anticoagulant drug during hospitalization. The most prescribed drug combination was enoxaparin+warfarin followed by enoxaparin+acenocoumarol. For discharge medicines, 14 patients were prescribed oral anticoagulants; 9 (64.3%) patients were prescribed with warfarin and the remaining 5 (35.7%) patients were given acenocoumarol. 28(56%) patient’s laboratory tests were evaluated for parameters like prothrombine time (PT) and international normalized ratio (INR). In the remaining 22(44%) patients, the above tests were not performed. Sixteen drug interactions were identi­fied, ten were pharmacodynamics and the rest six were pharmacokinetic interac­tions. Three adverse drug reactions were reported during the study. The need for dosage adjustment in differ­ent diagnostic situations or specific populations is very crucial. Conclusion: The therapy with these drugs needs to be cost effective and reduce the complications associated with their use.
Keywords: Anticoagulants, Drug utilization evaluation, Drug interactions.
Method development, validation and comparative study of generic Vs. branded generic formulations of amoxicillin trihydrate in capsule dosage form
Authors: Gandhi Santosh V. , Mahajan Mohitosh R. 
Published: September 2024

The present work relates to development and validation of simple, precise and sensitive UV spectrometric and high-performance thin layer chromatographic (HPTLC) method for the analysis of Amoxicillin Trihydrate in Capsule dosage form. Method were developed and applied for comparative study of generic vs branded generic formulations of Amoxicillin Trihydrate. Amoxicillin Trihydrate in methanol shows maximum absorbance at 229 nm and the data of linear regression analysis indicated a good linear relationship over the concentration range of 5-30 µg/ml with a correlation coefficient (R2) 0.998 by UV- Spectroscopy and the concentration range of 2000-12000 ng/band with a correlation coefficient (R2) 0.997 by HPTLC. The main objective was to compare and evaluate the price and quality of branded generic and generic formulations of Amoxicillin Trihydrate 250 mg Capsule. The evaluation parameters like content of active ingredients, content uniformity test, mass variation, disintegration test, and in vitro release studies were performed as described in Indian Pharmacopeia 2010.
Keywords: Branded Generic, Generic, Quantitative and Qualitative Determination, Ultraviolet Spectroscopy, HPTLC, Comparative Studies.