bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the phosphatidylethanolamine‐binding protein (PEBP) gene family reveals cryptic FLOWERING LOCUS T gene homologs in gymnosperms and sheds new light on functional evolution
Authors: Liu Yan‐Yan , Yang Ke‐Zhen , Wei Xiao‐Xin , Wang Xiao‐Quan 
Published: July 2016

Summary

Angiosperms and gymnosperms are two major groups of extant seed plants. It has been suggested that gymnosperms lack FLOWERING LOCUS T (FT), a key integrator at the core of flowering pathways in angiosperms.

Taking advantage of newly released gymnosperm genomes, we revisited the evolutionary history of the plant phosphatidylethanolamine‐binding protein (PEBP) gene family through phylogenetic reconstruction. Expression patterns in three gymnosperm taxa and heterologous expression in Arabidopsis were studied to investigate the functions of gymnosperm FT‐like and TERMINAL FLOWER 1 (TFL1)‐like genes.

Phylogenetic reconstruction suggests that an ancient gene duplication predating the divergence of seed plants gave rise to the FT and TFL1 genes. Expression patterns indicate that gymnosperm TFL1‐like genes play a role in the reproductive development process, while GymFT1 and GymFT2, the FT‐like genes resulting from a duplication event in the common ancestor of gymnosperms, function in both growth rhythm and sexual development pathways. When expressed in Arabidopsis, both spruce FT‐like and TFL1‐like genes repressed flowering.

Our study demonstrates that gymnosperms do have FT‐like and TFL1‐like genes. Frequent gene and genome duplications contributed significantly to the expansion of the plant PEBP gene family. The expression patterns of gymnosperm PEBP genes provide novel insight into the functional evolution of this gene family.
Between exclusion and emancipation: Foucault's ethics and disability
Authors: Pezdek Krzysztof , Rasiński Lotar 
Published: July 2016

AbstractThe aim of the study was to demonstrate how Foucault's ethics, which we understand as a tension between exclusion and emancipation, helps both critically reassess two disability models that prevail in the contemporary literature concerning disability, that is the medical model and the social one, and support and inspire an ethical project of including people with disabilities in spheres of life from which they have been excluded by various power/knowledge regimes. We claim, following Foucault, that such a project should be informed by critical reflection on exclusion‐generating forms of knowledge about people with disabilities and focused on individual ethical actions fostering self‐realization and emancipation of people with disability.
Genetic analysis and molecular mapping of resistance to Puccinia striiformis f. sp. pseudo‐hordei in common wheat
Authors: Dracatos P. M. , Haghdoust R. , Singh D. , Park R. F. 
Published: July 2016

This is the first genetic study reporting on the interaction and molecular mapping of resistance to the barley grass stripe rust pathogen (Puccinia striiformis f. sp. pseudo‐hordei, Psph) in common wheat. Seedlings of 638 wheat accessions were tested and it was determined that wheat is a near‐nonhost to Psph based on rare susceptibility observed in <2% of commercial cultivars and <5% of wheat landraces. As previously observed for P. striiformis f. sp. tritici (Pst), the Australian cultivar Teal was highly susceptible to Psph. In contrast, a selection of cv. Avocet carrying complementary resistance genes Yr73 and Yr74 (Avocet R; AvR) was resistant. The Teal × AvR (T/A) doubled haploid (DH) population was used to map resistance in AvR to Psph. Infection types on the T/A DH lines inoculated with Psph and Pst indicated that all DH lines carrying both Yr73 and Yr74 were also resistant to Psph; however, fewer DH lines were susceptible to Psph than expected, suggesting the resistance was more complex. QTL analysis using 9053 DArT‐Seq markers determined that resistance to Psph was polygenically inherited and mapped to chromosomes 3A, 3D, 4A and 5B. The 3DL and 5BL markers co‐located with Yr73 and Yr74, suggesting an overlap between host and non‐host resistance mechanisms.
The Construction and Use of Hope within Health‐Settings: Recent Developments in Qualitative Research and Ethnographic Studies
Authors: de Graaf Sabine 
Published: July 2016

AbstractQualitative and ethnographic studies within sociology and anthropology have paid increasing attention to the concept of hope. This review focuses on the analysis of hope within contexts of health and healthcare. An all‐compassing definition has continued to prove elusive, though studies have brought forth useful insights on the conceptualization and nature of hope. The article explores three common themes which emerged from recent literature. The first theme emphasizes different ways in which hope is enacted by people to ensure that hope can be maintained. The second theme focuses on the ways hope can transcend different frames of future time through the imagination of future possibilities, as well as moving people to cross‐geographical and imaginative borders. Finally, the third theme highlights insights into tensions that seem to be inherent to hoping. Hope proves to be ambivalent, as there always remains a possibility that the future which people imagined is not realized. The review shows that more empirical material is needed to understand how people deal with these tensions and how these tensions relate to the fluctuating nature and experience of hope. This offers interesting directions for further research on hope, both withinandoutside the context of health and healthcare.
The Field of American Media Sociology: Origins, Resurrection, and Consolidation
Authors: Brienza Casey , Revers Matthias 
Published: July 2016

AbstractThis contribution is written against the backdrop of the historic dispersal of early American media sociology out from the core concerns of the discipline and into various importer academic disciplines (including communication, journalism, and media studies) and an ever‐growing pervasiveness of media in everyday life which is reflected by a resurgence of sociological scholarship in the United States since the early 2000s. The article divides the field in works that study media inwards – along the threefold dimensions of production and technologies, communication and discourse, reception and effects – and works that study media outwards. We argue that this latter perspective, examining broader theoretical, methodological, and substantive social implications of mass‐mediated communication, is the most promising one for a mature field of American media sociology. On this basis, we conclude with some suggestions regarding possible new, and as of yet understudied, lines of inquiry for future media sociologists.
Globalization and Its Countermovement: Marxian Contention or Polanyian Resistance?
Authors: Gemici Kurtuluş , Nair Manjusha 
Published: July 2016

AbstractThis article surveys the scholarship on the countermovement against the diffusion of capitalism and market economy in the Global South. We identify two streams of analysis in the literature. On the one hand, scholars observe contentious politics instances where the spread of capitalist production relations enables the associational capacity and bargaining power of social classes. On the other hand, there are voluminous studies on contentious politics in the Global South where groups such as peasants, shopkeepers, and urban poor resist the intensification of the market economy. We use Beverly Silver's distinction between Marx‐type and Polanyi‐type protests, which focuses on how globalization makes and unmakes social groups, to unpack the heterogeneity of the impacts and experiences of globalization. We argue that although Silver's distinction is of great analytical value, there are strong warrants for separating the effects of the market economy from capitalism in studying contentious politics against globalization. Such an analytical strategy (i) expands the scope of the distinction between Marxian and Polanyian contention to social groups other than the working class and (ii) emphasizes that the roots of these struggles lie in the interconnected diffusion of capitalism and market economy.
Determinants of Smoking and Cessation Among Latinos: Challenges and Implications for Research
Authors: Castro Yessenia 
Published: July 2016

AbstractTobacco is a significant burden to individual and public health, and disparities exist among Latino smokers with respect to use and cessation. Although the prevalence of smoking is lower for Latinos than for non‐Latino Whites and the general U.S. population, numerous health disparities exist within the population of Latino smokers. Much is known about determinants of smoking and cessation but the vast majority of this knowledge is based on research with non‐Latino White smokers. This results in at least two important challenges in tobacco research among Latino smokers: (i) demonstrating the generalizability of known determinants of smoking and cessation, and; (ii) identifying culturally relevant variables that influence smoking and cessation among Latinos. An argument for increased research in these areas is presented with a review of existing research among Latino smokers that demonstrates these needs. Research is summarized that suggests socioeconomic position, depressive symptomatology, physical dependence, and gender function differently as determinants of smoking and cessation among Latinos compared with the general population of smokers. Research is also reviewed that suggests the promise of acculturation, acculturative stress, and discrimination as culturally relevant determinants of smoking and cessation. Research and practice implications are discussed, and specific areas for future research are offered.
Cryopreserved platelet concentrate transfusions in 43 dogs: a retrospective study (2007–2013)
Authors: Ng Zenithson Y. , Stokes Jennifer E. , Alvarez Lucia , Bartges Joe W. 
Published: July 2016

AbstractObjectiveTo clinically characterize a group of thrombocytopenic dogs that received cryopreserved platelet concentrate (cPC) transfusion, assess efficacy of cPC treatment in improving patient outcome, and compare treated dogs to a control population of thrombocytopenic dogs that did not receive cPC transfusions.DesignRetrospective study.SettingUniversity teaching hospital.AnimalsEighty‐six client‐owned dogs (43 in treatment group, 43 in control group).InterventionsNone.Measurements and Main ResultsMedical records of thrombocytopenic dogs that received cPC transfusions and those of thrombocytopenic dogs that did not receive cPC (control population) from January 2007 through March 2013 were reviewed. Dogs receiving cPC were statistically more likely than controls to have a platelet trigger for cPC transfusion (P= 0.01), lower platelet count (P= 0.009) and hematocrit at presentation (P= 0.001), and lower hematocrit after cPC (P= 0.02). Although there was a statistically significant increase in platelet count from pre‐ to post‐cPC transfusion (P= 0.002), cPC was not found to be effective in improving clinical bleeding or increasing survival compared to the control group. No other characteristics were statistically different between groups. No dogs receiving cPC had an acute transfusion reaction during hospitalization.ConclusionsIn the population described in this study, cPC was not found to increase survival, but was well tolerated. Controlled, prospective studies are necessary to determine indications for and efficacy of cPC transfusions.
Rescuing cardiac automaticity in L‐type Cav1.3 channelopathies and beyond
Authors: Mesirca Pietro , Bidaud Isabelle , Mangoni Matteo E. 
Published: July 2016

AbstractPacemaker activity of the sino‐atrial node generates the heart rate. Disease of the sinus node and impairment of atrioventricular conduction induce an excessively low ventricular rate (bradycardia), which cannot meet the needs of the organism. Bradycardia accounts for about half of the total workload of clinical cardiologists. The ‘sick sinus’ syndrome (SSS) is characterized by sinus bradycardia and periods of intermittent atrial fibrillation. Several genetic or acquired risk factors or pathologies can lead to SSS. Implantation of an electronic pacemaker constitutes the only available therapy for SSS. The incidence of SSS is forecast to double over the next 50 years, with ageing of the general population thus urging the development of complementary or alternative therapeutic strategies. In recent years an increasing number of mutations affecting ion channels involved in sino‐atrial automaticity have been reported to underlie inheritable SSS. L‐type Cav1.3 channels play a major role in the generation and regulation of sino‐atrial pacemaker activity and atrioventricular conduction. Mutation in the CACNA1D gene encoding Cav1.3 channels induces loss‐of‐function in channel activity and underlies the sino‐atrial node dysfunction and deafness syndrome (SANDD). Mice lacking Cav1.3 channels (Cav1.3−/−) fairly recapitulate SSS and constitute a precious model to test new therapeutic approaches to handle this disease. Work in our laboratory shows that targeting G protein‐gated K+ (IKACh) channels effectively rescues SSS of Cav1.3−/− mice. This new concept of ‘compensatory’ ion channel targeting shines new light on the principles underlying the pacemaker mechanism and may open the way to new therapies for SSS.
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In silico proposition to predict cluster of B- and T-cell epitopes for the usefulness of vaccine design from invasive, virulent and membrane associated proteins of C. jejuni
Authors: Yasmin Tahirah , Akter Salma , Debnath Mouly , Ebihara Akio , Nakagawa Tsutomu , Nabi A. H. M. Nurun 
Published: July 2016

Abstract
Purpose
Campylobacter jejuni is the one of the leading causes of bacterial diarrheal illness worldwide. This study aims to design specific epitopes for the utility of designing peptide vaccine(s) against C. jejuni by targeting invasive, virulent and membrane associated proteins like FlaA, Cia, CadF, PEB1, PEB3 and MOMP.

Methods
In the present study, various immunoinformatics approaches have been applied to design a potential epitope based vaccine against C. jejuni. The tools include Bepipred, ABCpred, Immune Epitope databse (IEDB) resource portal, Autodock vina etc.

Results
Peptides “EINKN”, “TGSRLN”, “KSNPDI”, “LDENGCE” respectively from FlaA, MOMP, PEB3, CadF proteins were found to be the most potential B cell epitopes while peptides “FRINTNVAA”, “NYFEGNLDM”, “YKYSPKLNF”, “YQDAIGLLV”, “FRNNIVAFV” and “LIMPVFHEL” respectively from Fla, CadF, MOMP, PEB1A, PEB3 and Cia might elicit cell mediated immunity and “IFYTTGSRL” from MOMP protein might elicit both humoral and cell-mediated immunity. All these potential peptidic epitopes showed almost 80–100 % conservancy in different strains of C jejuni with varying proportions of population coverage ranging from 22–60 %. Further authentication of these peptide epitopes as probable vaccine candidate was mediated by their binding to specific HLA alleles using in silico docking technique.

Conclusion
Based on the present study, it could be concluded that these predicted epitopes might be used to design a vaccine against C. jejuni bacteria and thus, could be validated in model hosts to verify their efficacy as vaccine.
The effect of technology-exploration on product innovation: an analysis based on Korean manufacturing SMEs
Authors: Lee Hojin , Cha Sangyoon , Park Heejun 
Published: July 2016

AbstractToday, fierce competition drives firms in their continual efforts to introduce products with a higher degree of novelty into the market. There is a growing need to understand important activities so as to achieve product innovation. This empirical study demonstrates the effect of technology-exploration, including outsourcing R&D, external networking, customer involvement, and inward IP licensing, on product innovation, especially considering the degree of the novelty of the manufactured products. Using data from a sample of small and medium Korean manufacturing firms, our results show that technology-exploration are crucial determining factors as to whether low or higher degree of novelty is achieved in product innovation. The positive impact of higher degree of innovation novelty comes from customer involvement and outsourcing R&D. In addition, customer involvement has positive impact only on low degree of innovation. Other practices have no impact on either low or high degree of novelty in product innovation.
Formation of conditions for increasing the investment attractiveness of the film industry in Russia
Authors: Аракелян Артур , Arakelyan Artur 
Published: July 2016

For a long time the industry of cinematography in Russia has been unprofitable, which in turn determines the difficulty in finding investment for new film projects. The part of Russian films in total box office of domestic distribution is negligibly small, the most produced Russian film projects do not pay back the investment made in them. The situation is critical and requires a comprehensive approach to the analysis of all the possible causes of this situation and to develop measures and create conditions to increase investment attractiveness
of this industry in Russia. They are still making incompleted attempts to reform the industry, for example, an adjustment has been made in the distribution system of state support, multiple meetings with theater owners have been held where they taked about a voluntary increase of quotas on rolled domestic films and a number of other measures. However, all these measures are chaotic, and therefore futile, attempts to correct the current situation, do not have single cohesive system of designed reforms that will help to improve the overall
investment attractiveness of this industry. The article attempts to analyze the reasons that have not allowed the domestic film industry to become powerful, profitable and, most importantly, attractive for investment for a long time. The article also suggests actions that should be implemented and adapted to the Russian realities, to increase the investment attractiveness of the film industry in Russia that can serve as a locomotive for the
output of the industry from years of systemic crisis.
Event tourism and event management according to the materials of historical reconstruction in Spain
Authors: Батурин Алексей , Baturin Aleksey 
Published: July 2016

The article analyzes the experience of the organization of event tourism and event management in the framework of the historical reconstruction in Spain. For consideration of the involved material of historical reenactment at Castillo Conde de Alfaz and Villajoyosa, which is part of the popular tourist centre of Spain. These tourist destinations are located in the area of Benidorm, attracting a large number of Spanish and foreign
tourists, not only due to the unique natural conditions (combination of sea beaches, mountains and numerous cultural and commercial centre of Benidorm), but also due to the possibility to dive into one of the most striking historical eras of Spain – ​middle Ages, thanks to well-organized historical reconstruction. The article considers the main forms and methods of historical reconstruction, contributing to the successful promotion of tourism products. The material can serve as a guide for organizers of tourism and potential tourists interested in the history and culture of Spain.
Developing An Optimization Model For Managing Energy Efficiency Programs
Authors: ��������  , Frolkina Ekaterina , �������  , Tsarkov Igor 
Published: July 2016

Energy saving in all economic sectors is one of the most important strategic
objectives of the 21st century. Energy efficiency programs are usually implemented
in parallel with core activities of the company and thereby create an
additional burden on limited budget. Cost-effectiveness of such a program
is not always obvious so the decision to start can be delayed, and actual result
may not be the expected one. In order to ensure economic efficiency the
authors offer to use the tool of mathematical modeling to optimize energy
efficiency program. The paper also presents the results of existing research
analysis on the different approaches towards mathematical modeling of
programs, the authors identify four main goals of the simulation. The authors�
approach is aimed at optimizing energy efficiency program for one or
more criteria within certain restrictions.
Enhanced recovery after surgery: An opportunity to improve fractured neck of femur management
Authors: Wainwright TW , Immins T , Middleton RG 
Published: July 2016

Introduction Approximately 67,000 hip fractures occurred in England, Wales and Northern Ireland in 2014, and annual hospital costs for fracture are around £1.1 billion. We review the potential scope for improving length of stay (LOS). Methods Hospital Episode Statistics data on non-elective admissions to 137 hospital trusts between November 2013 and October 2015 with a primary diagnosis of fractured neck of femur were analysed. The primary outcome was superspell LOS, which is the total LOS for all related spells for a single patient during an episode of care. Secondary outcomes were discharge to home, readmission at 28 days and in-hospital mortality. Results The mean observed LOS was 22.1±3.8 days (range 12.3-33.7 days). The range for case mix-adjusted expected LOS was 21.5-24.4 days. On average, 6.7±1.5% (range 3.6%-10.9%) of patients died while in hospital, at a relative risk of in-hospital mortality of 28.2-182.9. A mean of 12.3±3.2% (range 3.9% to 23.0%) of patients were readmitted at 28 days, at a relative relative risk of 34.8-203.2. Conclusions The wide range of observed LOS in our study is unlikely to be due to the case mix, as the case mix-adjusted range of LOS is less than 3 days, but rather due to local processes and pathways. There is therefore considerable scope for quality and efficiency of care improvements in our hospitals. We propose this could be best achieved if clinicians experienced in enhanced recovery focused on FNOF pathways.
Identifying Dosage Effect of Light-Emitting Diode Therapy on Muscular Fatigue in Quadriceps
Authors: Hemmings Thomas J. , Kendall Kristina L. , Dobson John L. 
Published: July 2016

Abstract
Hemmings, TJ, Kendall, KL, and Dobson, JL. Identifying dosage effect of light-emitting diode therapy on muscular fatigue in quadriceps. J Strength Cond Res 31(2): 395–402, 2017—The purpose of this study was to compare the effects of various dosages of light-emitting diode therapy (LEDT) on muscle fatigue while performing a single-leg extension to exhaustion. A total of 34 recreationally resistance-trained athletes between the ages of 18 and 26 participated in 4 trials. Each trial included pre-exercise/postexercise blood lactate measurements and 2 sets of 3 maximal voluntary isometric contractions (MVICs), followed by LEDT on 6 points across the superficial quadriceps. Each randomized trial consisted of a placebo, 30, 60, or 120 seconds on each point on the quadriceps. Three minutes after LEDT, the participants performed an eccentric leg extension with 120% of MVIC until fatigue. There was significant increase in the number of repetitions performed between the placebo treatment and 60 seconds (p = 0.023), as well as placebo and 120 seconds (p = 0.004) of irradiation on each point. There were no significant differences in blood lactate levels between any of the 4 trials. In conclusion, LEDT had a positive effect on performance when irradiating 6 points on the superficial quadriceps for 60 and 120 seconds before an eccentric leg extension.