bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic and Prognostic Implications of Ribosomal Protein Transcript Coordination in Human Cancers
Authors: Dolezal James M. , Dash Arie P. , Prochownik Edward V. 
Published: July 2017

AbstractRibosomes, the organelles responsible for the translation of mRNA, are comprised of rRNA and ~80 ribosomal proteins (RPs). Although canonically assumed to be maintained in equivalent proportions, some RPs have been shown to possess differential expression across tissue types. Dysregulation of RP expression occurs in a variety of human diseases, notably in many cancers, and altered expression of some RPs correlates with different tumor phenotypes and patient survival. To investigate the impact of global RP transcript (RPT) expression patterns on tumor phenotypes, we analyzed RPT expression of ~10,000 human tumors and 700 normal tissues witht-distributed stochastic neighbor embedding (t-SNE). We show here that normal tissues and cancers possess readily discernible RPT expression patterns. In tumors, this patterning is distinct from normal tissues, distinguishes tumor subtypes from one another, and in many cases correlates with molecular, pathological, and clinical features, including survival. Collectively, RPT expression can be used as a powerful and novel method of tumor classification, offering a potential clinical tool for prognosis and therapeutic stratification.
The IFN response in bat cells consists of canonical and non-canonical ISGs with unique temporal expression kinetics
Authors: De La Cruz-Rivera Pamela C. , Kanchwala Mohammed , Liang Hanquan , Kumar Ashwani , Wang Lin-Fa , Xing Chao , Schoggins John W. 
Published: July 2017

AbstractBats are reservoirs for a number of highly pathogenic zoonotic viruses, yet they remain relatively asymptomatic during infection. Whether this viral resistance is due to a unique innate immune system is unknown. An evolutionarily conserved feature of vertebrate antiviral immunity is the interferon (IFN) response, which triggers cellular defenses through interferon-stimulated gene (ISG) expression. While bats encode an intact IFN system, global ISG expression patterns in bat cells are not well characterized. Here, we used RNA-Seq to assess the transcriptional response to IFNα in cells derived from the batPteropus alecto(black flying fox). We show induction of more than 100 transcripts, most of which are canonical ISGs observed in other species. Kinetic gene profiling revealed thatP. alectoISGs fall into two unique temporal subclusters with similar early induction kinetics but distinct late-phase declines. In contrast to bat ISGs, human ISGs generally remained elevated for longer periods following IFN treatment, suggesting host-based differences in gene regulatory mechanisms. Notably, we also identified a small group of non-canonical bat ISGs, including an enzymatically active RNASEL that plays a role in controlling viral infection. These studies provide insight into the innate immune response of an important viral reservoir and lay a foundation for studies into the immunological features that may underlie unique virus-host relationship in bats.Significance StatementBats are considered unique in their ability to resist disease caused by viruses that are often pathogenic in humans. While the nature of this viral resistance is unknown, genomic data suggest bat innate immune systems may be specialized in controlling these disease-causing viruses. A critical cell intrinsic antiviral defense system in vertebrates is the interferon response, which suppresses viral infection through induction of hundreds of interferon-stimulated genes (ISGs). In this study, we report the repertoire of ISGs and several unique features of ISG induction kinetics in bat cells. We also characterize induction and antiviral activity of bat RNASEL, which is induced by IFN in bat, but not human cells. These studies lay the foundation for discovery of potentially new antiviral mechanisms in bats, which may spur research into development of therapies to combat viral infection.
Effective use of human physiological metrics to evaluate website usability
Authors: Qu Qing-Xing , Guo Fu , Duffy Vincent G. 
Published: July 2017

Purpose
The evaluation of website usability is the precondition and a critical step for website design and optimization. The purpose of this paper is to investigate and provide empirical evidence of the interrelationships between human physiological metrics and website usability. This study examines how eye-movement metrics and heart rate variability (HRV) evaluate website usability, and then affect users’ online surfing behavior.

Design/methodology/approach
A physiological measurement experiment is designed to collect participants’ physiological metrics. This paper proposes an objective measurement model for website usability, and partial least squares is used to analyze the measurement and structural models, based on data collected from 200 participants who had experienced online surfing at least four times.

Findings
The analysis supports partially or fully 28 of the 31 hypotheses formulated. The study reveals that human physiological metrics (i.e. fixation duration, fixation count, blink count, HRV) have a strong explanatory ability for website usability.

Research limitations/implications
Data for this study were collected only from mainland China. Therefore, participants may have been influenced by Chinese cultures. The generalizability of this study may be enhanced by collecting data from more diverse samples and validating the model on different cultures.

Originality/value
This study contributes significantly to the industry by providing empirical evidence of the interrelationship between human physiological metrics and website usability. The findings also provide managers with valuable insight into better understanding of the nature of these interrelationships.
An exploratory study of health scientists’ data reuse behaviors
Authors: Joo Soohyung , Kim Sujin , Kim Youngseek 
Published: July 2017

PurposeThe purpose of this paper is to examine how health scientists’ attitudinal, social, and resource factors affect their data reuse behaviors.Design/methodology/approachA survey method was utilized to investigate to what extent attitudinal, social, and resource factors influence health scientists’ data reuse behaviors. The health scientists’ data reuse research model was validated by using partial least squares (PLS) based structural equation modeling technique with a total of 161 health scientists in the USA.FindingsThe analysis results showed that health scientists’ data reuse intentions are driven by attitude toward data reuse, community norm of data reuse, disciplinary research climate, and organizational support factors. This research also found that both perceived usefulness of data reuse and perceived concern involved in data reuse have significant influences on health scientists’ attitude toward data reuse.Research limitations/implicationsThis research evaluated its newly proposed research model based on the theory of planned behavior using a sample from the community of scientists’ scholar database. This research showed an overall picture of how attitudinal, social, and resource factors influence health scientists’ data reuse behaviors. This research is limited due to its sample size and low response rate, so this study is considered as an exploratory study rather than a confirmatory study.Practical implicationsThis research suggested for health science research communities, academic institutions, and libraries that diverse strategies need to be utilized to promote health scientists’ data reuse behaviors.Originality/valueThis research is one of initial studies in scientific data reuse which provided a holistic map about health scientists’ data sharing behaviors. The findings of this study provide the groundwork for strategies to facilitate data reuse practice in health science areas.
Simultaneous relationship between performance and executive compensation of Thai non-financial firms
Authors: Buachoom Wonlop 
Published: July 2017

Purpose
The purpose of this paper is to determine the two-direction relationship between financial firm performance and executive compensation in Thai listed companies; that is, effect of firm performance on executive compensation and the effect of executive compensation on subsequent firm performance. In investigating the relationship, governance, firm-specific and human capital characteristics, which should influence on the pay-performance system, are also considered. This study helps to shape an understanding of the effectiveness of the incentive system in the Thai context.

Design/methodology/approach
The System GMM, with concern about the endogeneity problem of the simultaneous relationship, is applied to examine the relationship between firm performance and executive compensation. The samples to investigate this relationship composed of 5,139 firm-years observations for 15 years from the years 2000 to 2014 of 432 non-financial firms in the Thai stock market.

Findings
The empirical evidence reveals simultaneous relationship between performance and executive compensation in Thai stock market. It shows that compensation of executives in Thai firms corresponds to firm performance, and compensation of executives leads to an improvement in subsequent performance of Thai listed firms. Moreover, some corporate governance mechanisms and human capital of executives also revealed their particular effects on setting of the pay for performance system in Thailand.

Originality/value
This study confirms that the pay for performance system is applicable in Thailand. Furthermore, the empirical results of this study highlight effects of some governance and human capital characteristics on setting of the pay-performance system. Thus, this study should be a part of the growing body of literature in this area.
Political connections, corporate governance, and tax aggressiveness in Malaysia
Authors: Abdul Wahab Effiezal Aswadi , Ariff Akmalia M. , Madah Marzuki Marziana , Mohd Sanusi Zuraidah 
Published: July 2017

PurposeThe purpose of this paper is to examine the relationship between political connections and corporate tax aggressiveness in Malaysia. In addition, this paper investigates the relationship between corporate governance variables and corporate tax aggressiveness. Next, the study investigates the mitigating role of corporate governance in the relationship between political connections and corporate tax aggressiveness.Design/methodology/approachThe sample of this study is based on 2,538 firm-year observations during the 2000-2009 periods. This study employs a panel least square regression with both period and industry fixed effects. The study retrieved the corporate governance variables from the downloaded annual reports, whilst the remaining data were collected from Compustat Global.FindingsThis study finds that politically connected firms are more tax aggressive than non-connected firms. Furthermore, the study finds that large board size decreases the likelihood of tax aggressiveness and a non-linear relationship exists between institutional ownership and tax aggressiveness suggesting increase in monitoring as the ownership increases. However, the study finds no evidence to suggest that corporate governance mitigates the influence of political connections in promoting tax aggressiveness behavior. The findings suggest that the impact of political connections could outweigh the benefits of changes in corporate governance in Malaysia.Research limitations/implicationsThe data are not recent, but it reflects a rather longitudinal research period.Originality/valueThis paper extends the literature of tax research in Malaysia which is in its’ infancy stage. Furthermore, it investigates the role of political connections in tax-planning research.
Does recycling improve information usefulness of income? The case of Japan
Authors: Frendy  , Semba HU Dan 
Published: July 2017

Purpose
The Accounting Standards Board of Japan (ASBJ) proposed a new set of endorsed International Financial Reporting Standards in June 2015. ASBJ claims that non-recycling of other comprehensive income (OCI) items decreases the information usefulness of earnings in a proposed comprehensive income standard. There has been no existing empirical evidence which supports the ASBJ’s statement and the purpose of the study is to test whether OCI recycling improves information usefulness of net income from six perspectives: relative and incremental value relevance, persistence, variability, operating cash flow and net income predictive power.

Design/methodology/approach
This paper is an empirical work using a listed Japanese firms sample of 5,385 firm-years from fiscal year 2012-2014.

Findings
The results challenge the ASBJ’s claim that recycling improves the general information usefulness characteristics of net income. The empirical results show that OCI recycling improves net income’s relative value relevance characteristic of financial firms. However, recycling information by itself does not improve the incremental value relevance, and the predictive power of operating cash flow and net income. The authors also find that the inclusion of recycling decreases the persistence and increases the variability of net income.

Research limitations/implications
This paper has two research limitations. First, this study is constrained to analyze a limited OCI recycling data that is recently disclosed by listed Japanese firms. Second, the results of this study have limited external validity to capital markets with OCI reclassification standards that deviate from Japanese GAAP.

Originality/value
This study provides initial empirical evidence that examines information usefulness of OCI recycling in Japan. The findings of this study are relevant for accounting standards setters aiming to increase the information usefulness of earnings for capital market investors.
Students’ experience toward ePortfolios as a reflective assessment tool in a dual mode indigenous business course
Authors: Bodle Kerry Anne , Malin Mirela , Wynhoven Andrew 
Published: July 2017

Purpose
The purpose of this paper is to investigate students’ experiences of, and attitudes on, the use of technology – in the form of ePortfolio – as an assessment tool. The authors seek to determine whether ePortfolios aid students in facilitating critical reflection on their learning and academic skill development. The authors also determine whether ePortfolios can provide an alternative assessment tool to the traditional assessment practices in the accounting and business discipline.

Design/methodology/approach
This study surveys students enrolled in an indigenous business course using questions on the usability of ePortfolios, technical support and effectiveness in critical reflection and learning. Formal evaluations were included to capture students’ self-reflections on their ePortfolio experience. The analysis included analysis of variance, t-tests, correlations and hierarchical regression.

Findings
Results indicated that students show positive attitudes toward ePortfolios even after controlling for possible confounding variables such as previous experience, attitudes and accessibility. The authors also found that ePortfolios are a useful vehicle for enhancing students’ learning and understanding of indigenous knowledge in a business context. They were also found to facilitate students’ ability to critically reflect, engage in learning and develop their academic skills.

Research limitations/implications
The findings of this study could benefit those working in higher education, particularly accounting academics in Australian universities, and the adaptation of ePortfolios in a blended learning environment, and contribute to pedagogical knowledge regarding indigenous business issues. Academics could design the curriculum of the accounting courses within the commerce programme that addresses programme learning objectives to align with graduate employability outcomes.

Practical implications
This study provides a foundation for improving the design and assessment of written communication activities in accounting courses to achieve employability skills outcomes commensurate with university accreditation criteria. This could be achieved with the development of a community of practice developed by the professional accounting bodies in collaboration with Australian universities.

Originality/value
The research is not wholly new, although the use of ePortfolios in accounting education is not widely reported and, therefore, may be of interest to those in advancing the accounting education agenda. In light of the recent call by Australian professional accounting bodies, ePortfolios can provide accounting graduates the non-technical or soft skills such as communication, interpersonal and critical thinking.
Enhancing students understanding of introductory accounting by integrating split-attention instructional material
Authors: Sithole Seedwell T.M. 
Published: July 2017

Purpose
The purpose of this study is to investigate the effects of two instructional design formats on learning outcomes in introductory accounting.

Design/methodology/approach
This study describes split-source instructional designs and uses an experiment administered to two groups of students enrolled in an undergraduate introductory accounting subject. The performance scores in recall and transfer test items are used to evaluate students’ learning outcomes.

Findings
The study suggests that instructors can enhance students understanding of introductory accounting by integrating text and diagrams in introductory accounting.

Practical implications
University instructors require evidence of teaching and learning activities that enhance student learning during the study of introductory accounting. This study shows that a redesign of accounting instructional material improves students’ performance and learning experience.

Originality/value
This study addresses a gap in the literature by examining the use of integrated instructional materials as an alternative to the separate diagram and text when learning accounting. The study also explores the effect of reorganising learning material on students load by analysing the mental effort reported by students. Finally, the study contributes useful findings on reorganising accounting instructional material aimed at enhancing the understanding of introductory accounting.
Towards superhydrophobic and ultraviolet protective nylon fabrics
Authors: Teli Mangesh , Annaldewar Bhagyashri N. 
Published: July 2017

Purpose
The purpose of this paper is to prepare coloured superhydrophobic and ultraviolet (UV) protective nylon fabrics using nanosilica copper oxide coating.

Design/methodology/approach
In this study, brown coloured superhydrophobic nylon fabric exhibiting UV protective properties was prepared by step-wise deposition of silica nanoparticles, copper oxide and sodium stearate. The hydrophobicity of treated fabrics was characterised by water contact angle measurement and UV protection properties of fabric were assessed by Australian/New Zealand Standard. Also, a colouring effect of treatment on nylon fabric was measured using spectrophotometer.

Findings
The modified fabric not only exhibited superhydrophobicity with the water contact angle of 150.6°, but also rendered excellent protection against UV radiation. The fabric showed retention of hydrophobic and UV protection properties up to 20 washing cycles.

Originality/value
A novel method for imparting superhydrophobicity and UV protective properties along with colouration effect on nylon fabrics has been reported. This type of fabric has potential application in the field of protective clothing.
Effect of the difference between body dimensions and jacket measurements on the appearance of a ready-made tailored jacket
Authors: Monobe Ai , Kim KyoungOk , Takatera Masayuki 
Published: July 2017

Purpose
The purpose of this paper is to clarify changes in the appearance of a ready-made tailored jacket due to changes in the ease allowance and determine suitable ranges of the ease allowance for the jacket.

Design/methodology/approach
Images were taken of the front, side and back of a jacket placed on a dress form with varying sizes of bust, waist and hips. The authors observed the appearance of the jacket for the different sizes of the dress form. A sensory evaluation of the suitable range of ease allowance for the jacket involving 20 female Japanese university students was carried out. The evaluation items were the fit, beauty, comfort and purchase intention.

Findings
The jacket appearance was lowly evaluated if there were many wrinkles and highly evaluated if there was a curved silhouette. Changes in bust, sleeve and waist parts affected the evaluation of the suitable ranges of ease allowance. The suitable range of ease allowance varied depending on the jacket part and viewing direction. In terms of fit, the suitable ease allowance ranged between 5.6 and 9.9 percent for the bust, between 7.6 and 17.8 percent for the waist and between 2.6 and 8.6 percent for the hips. The suitable ranges were determined considering the wrinkling and silhouette in these parts.

Originality/value
Suitable ranges of ease allowance of a tailored jacket were determined by evaluating a jacket for 11 dress form sizes of the bust, nine sizes of the waist and seven sizes of the hips, at 2 cm intervals. The obtained suitable ease allowance ranges are useful to manufacturers in terms of garment design and to customers in terms of selecting suitable garments.
Leader perceptions and student achievement
Authors: Shin Seon-Hi , Slater Charles L. , Ortiz Steve 
Published: July 2017

Purpose
The purpose of this paper is to examine what factors affect student achievement in reading and mathematics. The research questions addressed the perceptions of school principals and background characteristics related to student achievement in Korea and the USA with respect to differences among students in low, middle and high quantiles.

Design/methodology/approach
Data were taken from the Program for International Student Assessment 2012. Scores in the reading and mathematics were analyzed in conjunction with a principal survey. The Quantile Regression method was used for data analysis with three quantile points. T-statistics were used to test for significance. The predictor set consisted of seven school-leadership variables, and four to six additional covariates.

Findings
The most important finding for the USA was a relationship between organizational hindrance (HND) and low student achievement for the middle and upper quantiles in mathematics and for all quantiles in reading. The (HND) variable included poor teacher-student relations, low expectation of students, overly strict enforcement of rules, lack of attention to student needs, resistance to change, lateness to class, and lack of preparation. The most important finding for Korea was that there were significant associations across all groups between teacher attitude (TCHATT) and student reading achievement and with the low group in mathematics.

Research limitations/implications
This study adds to knowledge about school capacity and suggests that the leadership role of the principal is to overcome negative environmental factors and create a positive organization.

Originality/value
The non-Gaussian approach of regression analysis allowed us to identify significant differences that we otherwise might not have found.