bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liraglutide improves metabolic parameters and carotid intima-media thickness in diabetic patients with the metabolic syndrome: an 18-month prospective study
Authors: Rizzo Manfredi , Rizvi Ali A. , Patti Angelo Maria , Nikolic Dragana , Giglio Rosaria Vincenza , Castellino Giuseppa , Li Volti Giovanni , Caprio Massimiliano , Montalto Giuseppe , Provenzano Vincenzo , Genovese Stefano , Ceriello Antonio 
Published: December 2016

Abstract
Background
Liraglutide, a GLP-1 analogue, exerts several beneficial non-glycemic effects in patients with type-2 diabetes (T2DM), such as those on body weight, blood pressure, plasma lipids and inflammation markers. However, the effects of liraglutide on cardiovascular (CV) risk markers in subjects with the metabolic syndrome (MetS) are still largely unknown. We herein explored its effects on various cardio-metabolic risk markers of the MetS in subjects with T2DM.

Methods
We performed an 18-month prospective, real-world study. All subjects had T2DM and the MetS based on the AHA/NHLBI criteria. Subjects with a history of a major CV event were excluded. One hundred-twenty-one subjects (71 men and 50 women; mean age: 62 ± 9 years) with T2DM and the MetS, who were naïve to incretin-based therapies and treated with metformin only, were included. Liraglutide (1.2 mg/day) was added to metformin (1500–3000 mg/day) for the entire study. Fasting plasma samples for metabolic parameters were collected and carotid-intima media thickness (cIMT) was assessed by B-mode real-time ultrasound at baseline and every 6 months thereafter.

Results
There was a significant reduction in waist circumference, body mass index, fasting glycemia, HbA1c, total- and LDL-cholesterol, triglycerides, and cIMT during the 18-month follow-up. Correlation analysis showed a significant association between changes in cIMT and triglycerides (r = 0.362; p < 0.0001). The MetS prevalence significantly reduced during the study, and the 26% of subjects no longer fulfilled the criteria for the MetS after 18 months.

Conclusions
Liraglutide improves cardio-metabolic risk factors in subjects with the MetS in a real-world study.
Trial Registration ClinicalTrials.gov: NCT01715428.
Improved tomographic reconstruction of large-scale real-world data by filter optimization
Authors: Pelt Daniël M. , De Andrade Vincent 
Published: December 2016

AbstractIn advanced tomographic experiments, large detector sizes and large numbers of acquired datasets can make it difficult to process the data in a reasonable time. At the same time, the acquired projections are often limited in some way, for example having a low number of projections or a low signal-to-noise ratio. Direct analytical reconstruction methods are able to produce reconstructions in very little time, even for large-scale data, but the quality of these reconstructions can be insufficient for further analysis in cases with limited data. Iterative reconstruction methods typically produce more accurate reconstructions, but take significantly more time to compute, which limits their usefulness in practice. In this paper, we present the application of the SIRT-FBP method to large-scale real-world tomographic data. The SIRT-FBP method is able to accurately approximate the simultaneous iterative reconstruction technique (SIRT) method by the computationally efficient filtered backprojection (FBP) method, using precomputed experiment-specific filters. We specifically focus on the many implementation details that are important for application on large-scale real-world data, and give solutions to common problems that occur with experimental data. We show that SIRT-FBP filters can be computed in reasonable time, even for large problem sizes, and that precomputed filters can be reused for future experiments. Reconstruction results are given for three different experiments, and are compared with results of popular existing methods. The results show that the SIRT-FBP method is able to accurately approximate iterative reconstructions of experimental data. Furthermore, they show that, in practice, the SIRT-FBP method can produce more accurate reconstructions than standard direct analytical reconstructions with popular filters, without increasing the required computation time.
Internet technologies in the mobilization of political protest (on the example of Euromaidan)
Authors: Абрамов  , Abramov Maksim , Фильченков  , Filchenkov Andrey , Азаров  , Azarov Artur , Домбровская  , Dombrovskaya Anna , Бродовская  , Brodovskaya Elena , Карзубов  , Karzubov Dmitriy 
Published: December 2016

The paper presents the results of cybermetric analysis of Ukrainian protesters&#96; digital footprints in social media (January – February, 2014). Strategies of forming attitudes of protest behavior of Ukrainian citizens in global network are analyzed. Empirical research model included event-analysis, typology reports of events considered using online Internet service monitoring social media and messaging discourse analysis, forming protest attitudes in the Ukrainian users. Structural and meaningful analyses were subjected to digital traces of three periods of development of protest, identified during event analysis. Development of intensity markers allowed to carry out a structural analysis of Internet content, and determining the content of the markers provided semantic content circulating in the global communications network.
Discourse analysis of social media posts established dominance of certain technologies of negative mobilization of protesters: identification of political entities with public threat or sources of discontent; use anthropomorphic metaphors; broadcasting information of provocative character.
In the article the perspectives of further research, involving improvement of methods of analysis of formation protest activity on digital tracks are shown.
Morera y Gardel: «video clip» porteño
Authors: Gagliardi Jorge 
Published: December 2016

Eduardo Morera filmó 15 cortometrajes musicales coninterpretación de Carlos Gardel y producción de Fe-derico Valle en 1930, compilados con la denominaciónAsí cantaba Carlos Gardel. Suele clasificarse a estas obrascomo video clip, sin considerar la elaboración posteriorde este género a partir de los años 70, que su circulaciónmasiva comenzó en 1981 por parte de la mtv y que noson producciones de la televisión sino de la cinema-tografía. Por otra parte, a partir de ese ordenamientocircula una disputa por quién es el hacedor pionero deese tipo de texto cuatro décadas antes de la creación delgénero, entre Morera y Gardel, por un lado, y José Bohrpor otro, quien, según lo proferido en su autobiografía,habría hecho una actuación musical en un cortometraje—actualmente desaparecido— con producción de laParamount Pictures. Resulta pertinente, entonces, trataralgunas cuestiones sobre la producción y la recepción de estos cortometrajes, tendientes a incentivar la reflexiónacerca de su clasificación social.
Infancia y dictadura: los niños ante el terrorismo de Estado en el cine argentino
Authors: Triquell Ximena 
Published: December 2016

El presente trabajo forma parte de un proyecto mayorcuyo principal objetivo es analizar diferentes repre-sentaciones de la infancia en el cine argentino, con elobjetivo de observar de qué manera tales representa-ciones guardan relación con el momento histórico desu producción.En este trabajo abordamos la representación de niñosen relación con la dictadura a partir de tres ejes: a)como «objetos» de disputa, en una lógica de posesióno carencia, que refiere directamente a la apropiación debebés y niños por parte de los militares; como sucedeen La historia oficial (Puenzo, 1985) o, casi dos décadasdespués, en Cautiva (Biraben, 2005); b) como pequeñosadultos de quienes se espera que afronten la realidad,incluida la militancia de los padres, del mismo modoque lo hacen éstos —Un lugar en el mundo (Aristarain,1992), Kamtchatka (Piñeyro, 2002) y separada también por una década Infancia clandestina (Ávila, 2012)—; yc) como sujetos que miran a los adultos como por ejem-plo en Un muro de silencio (Stantic, 1993) o Amigomío(Meerapfel, 1994).
Las proyecciones de cine militante clandestinas al interior de las organizaciones políticas 1968–1973. La experiencia formativa
Authors: Andelique Carolina 
Published: December 2016

Este trabajo aborda el desarrollo de las proyecciones clan-destinas o alternativas de cine militantes realizadas al in-terior de diferentes organizaciones políticas entre los años1968 y 1973 en la ciudad de Santa Fe. En el contexto decensura y persecución instaurado por la dictadura militarde 1966, la realización de proyecciones de cine militantepor parte de organizaciones políticas se constituye en unacto mismo de militancia para los asistentes, quienes venen éstas una forma más de aportar a la discusión políticay social en la lucha por la liberación.A partir de la pregunta sobre qué vínculo existía entrelos distintos grupos realizadores de cine militante y lasorganizaciones políticas a mediados de los años sesenta, será posible comenzar a pensar cómo las proyeccionesde cine al interior de las organizaciones eran en sí unacto formativo para los militantes, y qué característicasasumía este tipo de proyecciones en los diferentes es-pacios en que se realizaba y a partir de la diversidad depúblico que podía concurrir.Los testimonios de ex militantes que participaroncomo asistentes u organizadores de este tipo de pro-yección clandestina o alternativa serán insumo de estetrabajo, permitiéndonos vislumbrar el valor que comoacto militante tenía dicha participación.
Entre el presente y el pasado, los documentos audiovisuales. Representaciones para la reconstrucción de historia/s reciente/s. Córdoba 1966–1983
Authors: Romano Silvia 
Published: December 2016

El tema aquí abordado se inscribe en el proyecto «Pa-trimonio audiovisual, derechos humanos e historiareciente» que, en líneas generales, se propuso contribuiral conocimiento sobre el conjunto de los destinatariosde la represión ilegal y el terrorismo de Estado en ladécada de 1970. La mayor parte de esas personas par-ticipó de la vida política, gremial, estudiantil, barrialde Córdoba en períodos previos a ser desaparecidos yasesinados por lo cual consideramos factible investigaren las noticias televisivas contemporáneas como recursoy fuente histórica para rescatar y restituir sus imágenes,sus voces y reconstruir sus trayectorias en el contextode la época. En ese marco el texto se interroga sobre elmodo en que esos registros audiovisuales contribuyen a que otros sujetos reconstruyan aspectos de ese pasado,sea para producir conocimiento científico o público,interpretaciones audiovisuales, o para elaborar y/ore–elaborar historias personales y grupales, centrandola mirada sobre este último aspecto.
Sociedad de riesgo: El incumplimiento de la Ley de Acceso a la Información por la Comisión Técnica Nacional de Bioseguridad (ctnBio) de Brasil
Authors: De Oliveira Nildete S. 
Published: December 2016

Este artículo hace un análisis sobre la falta de respeto a laLey de Acceso a la Información por la Comisión TécnicaNacional de Bioseguridad (ctnBio). El artículo tambiénreflexiona sobre los riesgos que existen en la sociedad con-temporánea relacionadas con la (ctnBio y el derecho delos ciudadanos y de la sociedad de acceso a la informacióna partir de una perspectiva ambiental. La argumentaciónparte de la comprensión de los conceptos de riesgo, desociedad de riesgo, de derecho a la información y de lanorma creadora de la (ctnBio. Se toma como parámetroun estudio de caso relacionado con el tratamiento dadoa la cuestión de riesgo ambiental y las informacionesproporcionadas por la Comisión Técnica (ctnBio). Seconcluyó que la sociedad, además de tener el derecho,también necesita conocer el grado de riesgo al cual estásiendo expuesta, así como sus consecuencias. Se sugierecomo medida para lograr la solución del problema, la creación inmediata del Sistema de Informaciones enBioseguridad —sib. Esto es para cumplir con la funciónde comunicar datos a la ctnBio que sean de interés paraese órgano y para la población como: sistematizar susinformes anuales con información clara que ayude al ciu-dadano a conocer los temas tratados; promover frecuentesaudiencias públicas con el objetivo de permitir y fomentarel diálogo entre el gobierno y los electores y finalmenteefectivizar el derecho de acceso a la información.
Research Progress in Oncology. Highlighting and Exploiting the Roles of Several Strategic Proteins in Understanding Cancer Biology
Authors: Odiba Arome S. , Ottah Victoria E. , Anunobi Ogechukwu O. , Edeke Affiong A. , Ukegbu Chimere Y. , Chukwunonyelum Ike , Onosakponome Irhuoghene , Joshua Parker E. 
Published: December 2016

AbstractAlthough almost all biological processes are mediated by a variety of proteins, it is important to bring to spotlight recent experimental and clinical research advances that had their focus on highlighting and taking advantage of the roles of several strategic proteins in order to gain more understanding of cancer biology. Proteins have a major stake in the initiation, progression, sustenance and completion of cellular processes, and have also demonstrated their vital roles in cancer processes. The characteristic functions of proteins and modified proteins have been utilized in the understanding and treatment of cancer. Recent insights in such roles and applications include linker histone H1.2 in the compaction of chromatin and gene silencing via the recognition of H3K27me3; c-Jun with Fra-2/c-Fos in the promotion of aggressive tumour phenotypes in tongue cancer; the use of sodium channelinhibiting agents targeting the transmembrane protein in breast, colon and prostate cancer; SET-mediated activities; protein interaction networks in glioma; Gpnmb significance as a biomarker; β-carbolines inhibition on Wnt/β-catenin signaling; p53 mutants co-opt chromatin pathways; Bone morphogenetic protein 4 as regulator of the behaviors of cancer cell; Brain-Expressed X-linked (BEX) proteins in human cancers; targeting CDK4/6 including protein kinases to make a reversal of multidrug resistance in sarcoma. In-depth knowledge of Proteomics will go a long way in helping us uncover a lot more strategies that will help us in the long fight against cancer.
Characterization of particle shape, zeta potential, loading efficiency and outdoor stability for chitosan-ricinoleic acid loaded with rotenone
Authors: Feng Bohua , Ashraf Muhammad Aqeel , Peng Liufen 
Published: December 2016

AbstractCarboxymethyl chitosan grafted with ricinoleic acid (CMC-g-RA), an amphiphilic drug carrier, was synthetized, loaded with rotenone (Rot), and characterized for particles shape, zeta potential, loading efficiency and outdoor stability. Results show that as the ratio of carrier to drug increased, the formulation exhibited monodisperse nanoparticles negative surface charge. The loading efficiency of the formulation was up to 68%. The outdoor test also indicated that the formulation with the higher loading efficiency prevented Rot degradation in natural environments.
Genetic diversity and population structure of ginseng in China based on RAPD analysis
Authors: Wang Shi-jie , Chen Xiao-lin , Han Feng-bo , Li Ru-sheng , Li Gang , Zhao Yan , Xu Yong-hua , Zhang Lian-xue 
Published: December 2016

AbstractPopulation genetic diversity was estimated from forty-four individual ginseng (Panax ginsengC.A. Meyer) plants collected from seven geographical populations located in Heilongjiang, Liaoning, and Jilin Provinces of China as well as the People’s Republic of Korea by using randomly amplified polymorphic DNA (RAPD) markers. Overall, 41 polymorphic loci were amplified using ten primer pairs. The polymorphism percentage ranged from 50% to 100% among seven local populations of ginseng, indicating that there is plentiful genetic diversity in wild ginseng populations. The genetic diversity at the species level was higher than that at the population level. Variance analysis showed that there was a significant difference among populations in genetic diversity. The genetic differentiation coefficient (i.e., FST) indicates that 43% of the variation occurred among populations, which indicates that substantial genetic differentiation occurred among populations. At the same time, the measured value of gene flow (Nm) was 0.66 based on the observed genetic differentiation coefficient among populations, suggesting there was moderate gene flow among populations.
Optimizing the extraction of antibacterial compounds from pineapple leaf fiber
Authors: Zhuang Zhikai , Zhang Jin , Li Mingfu , Deng Ganran , Ou Zhongqing , Lian Wenwei , He Junyan , Huang Tao 
Published: December 2016

AbstractFive different solvents (petroleum ether, chloroform, ethyl acetate, acetone, and distilled water) were used to extract antibacterial compounds from pineapple leaf fiber. Compounds extracted using acetone showed the greatest antibacterial effect against Escherichia coli, measured by inhibition zone diameter. Three extraction parameters including temperature, time and solid-liquid ratio were optimized through orthogonal experiment based on single factor investigations for achieving maximum active substance extraction rate and bacteriostatic effect. Results showed that using acetone, the optimum extraction conditions for temperature, time and solid-liquid ratio were 45°C, 8 h, and 1:40 (g/ml), respectively.
Identification of residual non-biodegradable organic compounds in wastewater effluent after two-stage biochemical treatment
Authors: Xuqing Liu , Yayun Li , Chao Liu , Li Zhang , Hao Yuan , Chao Fu , Ashraf Muhammad Aqeel 
Published: December 2016

AbstractThe main non-biodegradable compounds (soluble microbial product – SMP) of wastewater from the Maotai aromatic factories, located in the Chishui river region, were analyzed by UV spectroscopy, and by solid-phase extraction followed by gas chromatography coupled to mass spectrometry, after a two-stage biochemical treatment. The UV-Vis spectra revealed that the wastewater contained two double-bonds in conjugated systems (conjugated diene or α, β- unsaturated ketone, etc.) and simple non-conjugated chromophores containing n electrons from carbonyl groups or the like. The residual organic non-biodegradable substances were identified using SPE-GC/MS analysis as complex polymers containing hydroxyl, carbonyl, and carboxyl functional groups with multiple connections to either benzene rings or heterocyclic rings. As these compounds are difficult to remove by conventional biochemical treatments, our findings provide a scientific basis for the design of efficient new strategies to remove SMP from wastewater.
In-silico analysis of non-synonymous-SNPs of STEAP2: To provoke the progression of prostate cancer
Authors: Naveed Muhammad , Tehreem Sana , Mubeen Shamsa , Nadeem Fareeha , Zafar Fatima , Irshad Muhammad 
Published: December 2016

AbstractAs a novel biomarker from the STEAP family, STEAP2 encodes six transmembrane epithelial antigens to prostate cancer. The overexpression of STEAP2 is predicted as the second most common cancer in the world that is responsible for male cancer-related deaths. Nonsynonymous SNPs are important group of SNPs which lead to alternations in encoded polypeptides. Changes in the amino acid sequence of gene products can lead to abnormal tissue function. The present study firstly sorted out those SNPs which exist in the coding region of STEAP2 and evaluated their impact through computational tools. Secondly, the three-dimensional structure of STEAP2 was formed through I-TASSER and validated by different software. Genomic data has been retrieved from the 1000 Genome project and Ensembl and subsequently analysed using computational tools. Out of 177 non-synonymous single nucleotide polymorphisms (nsSNPs) within the coding region, 42 mis-sense SNPs have been predicted as deleterious by all analyses. Our research shows a welldesigned computational methodology to inspect the prostate cancer associated nsSNPs. It can be concluded that these nsSNPs can play their role in the up-regulation of STEAP2 which further leads to progression of prostate cancer. It can benefit scientists in the handling of cancerassociated diseases related to STEAP2 through developing novel drug therapies.
microRNAs in cardiovascular disease – clinical application
Authors: Schulte Christian , Karakas Mahir , Zeller Tanja 
Published: December 2016

AbstractmicroRNAs (miRNAs) are well-known, powerful regulators of gene expression, and their potential to serve as circulating biomarkers is widely accepted. In cardiovascular disease (CVD), numerous studies have suggested miRNAs as strong circulating biomarkers with high diagnostic as well as prognostic power. In coronary artery disease (CAD) and heart failure (HF), miRNAs have been suggested as reliable biomarkers matching up to established protein-based such as cardiac troponins (cT) or natriuretic peptides. Also, in other CVD entities, miRNAs were identified as surprisingly specific biomarkers – with great potential for clinical applicability, especially in those entities that lack specific protein-based biomarkers such as atrial fibrillation (AF) and acute pulmonary embolism (APE). In this regard, miRNA signatures, comprising a set of miRNAs, yield high sensitivity and specificity. Attempts to utilize miRNAs as therapeutic agents have led to promising results. In this article, we review the clinical applicability of circulating miRNAs in CVD. We are giving an overview of miRNAs as biomarkers in numerous CVD entities to depict the variety of their potential clinical deployment. We illustrate the function of miRNAs by means of single miRNA examples in CVD.
Effects of heat treatment and welding process on superelastic behaviour and microstructure of micro electron beam welded NiTi
Authors: Balz Isabel , Reisgen Uwe , Schoft Julia , Otten Christian 
Published: December 2016

Abstract
Medical devices with small dimensions made of superelastic NiTi become more popular, but joining these parts remains challenging. Since laser welding was found to be an option, electron beam welding seems to be an interesting alternative as it provides additional advantages due to the precise beam positioning and the high vacuum. Superelasticity is influenced by microstructure and surface layer composition that are mainly affected by welding process and by heat treatment and therefore will be investigated in the present paper.
Towards in silico prognosis using big data
Authors: Ohs Nicholas , Keller Fabian , Blank Ole , Lee Yuk-Wai Wayne , Cheng Chun-Yiu Jack , Arbenz Peter , Müller Ralph , Christen Patrik 
Published: December 2016

Abstract
Clinical diagnosis and prognosis usually rely on few or even single measurements despite clinical big data being available. This limits the exploration of complex diseases such as adolescent idiopathic scoliosis (AIS) where the associated low bone mass remains unexplained. Observed low physical activity and increased RANKL/OPG, however, both indicate a mechanobiological cause. To deepen disease understanding, we propose an in silico prognosis approach using clinical big data, i.e. medical images, serum markers, questionnaires and live style data from mobile monitoring devices and explore the role of inadequate physical activity in a first AIS prototype. It employs a cellular automaton (CA) to represent the medical image, micro-finite element analysis to calculate loading, and a Boolean network to integrate the other biomarkers. Medical images of the distal tibia, physical activity scores, and vitamin D and PTH levels were integrated as measured clinically while the time development of bone density and RANKL/OPG was observed. Simulation of an AIS patient with normal physical activity and patient-specific vitamin D and PTH levels showed minor changes in bone density whereas the simulation of the same AIS patient but with reduced physical activity led to low density. Both showed unchanged RANKL/OPG and considerable cortical resorption. We conclude that our integrative in silico approach allows to account for a variety of clinical big data to study complex diseases.