bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KOMPETENSI SUMBER DAYA MANUSIA DAN PEMANFAATAN TEKNOLOGI INFORMASI TERHADAP KUALITAS LAPORAN KEUANGAN PADA PEMERINTAH KABUPATEN KOLAKA
Authors: Nurdin Emillia , Labangu Yuli Lestari , Wahyuni Zahra , Fachmi Idris Muhammad 
Published: September 2024

Penelitian ini bertujuan untuk menguji dan mengetahui pengaruh kompetensi sumber daya manusia dan pemanfaatan teknologi informasi terhadap kualitas laporan keuangan. Sampel pada penelitian ini adalah pegawai bagian pengelola keuangan pada OPD Kabupaten Kolaka yaitu sebanyak 97 orang dengan menggunakan teknik pengambilan sampel Purpossive Sampling. Metode pengumpulan data menggunakan kuesioner, wawancara, dokumentasi dan studi kepustakaan. Analisis data menggunakan metode analisis deskriptif dan analisis linear berganda dengan bantuan aplikasi software IBM SPSS Statistics Versi 25. Hasil penelitian ini menunjukan bahwa (1) Kompetensi Sumber Daya Manusia berpengaruh positif terhadap Kualitas Laporan Keuangan, semakin baik kompetensi sumber daya manusia maka kualitas laporan keuangan yang disajikan akan semakin baik. (2) Pemanfaatan Teknologi Informasi berpengaruh positif terhadap Kualitas Laporan Keuangan. Hal tersebut menunjukkan bahwa semakin baik pemanfaatan teknologi informasi dalam kualitas laporan keuangan maka meningkatkan efektifitas dalam pengelolaan laporan keuangan. (3) dan Kompetensi Sumber Daya Manusia dan Pemanfaatan Teknologi Informasi berpengaruh terhadap Kualitas Laporan Keuangan pada OPD Kabupaten Kolaka. Kesimpulan penelitian ini yaitu semakin baik kompetensi sumber daya manusia dan penilaian pemanfaatan teknologi informasi maka kualitas laporan keuangan yang dihasilkan akan semakin baik juga.
PENGARUH PERSEPSI PELAKU USAHA MIKRO KECIL DAN MENENGAH DAN PENGETAHUAN AKUNTANSI TERHADAP PENGGUNAAN INFORMASI AKUNTANSI
Authors: Hadisantoso Erwin , Pebrianti Vina Olivia , Patima  
Published: September 2024

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh persepsi pelaku usaha mikro kecil dan menengah dan pengetahuan akuntansi terhadap penggunaan informasi akuntansi di Kota Kendari. Penelitian ini menggunakan teknik pengambilan sampel random sampling yang berjumlah 91 sampel pada UMKM di bidang kuliner yang ada di Kota Kendari. Metode pengumpulan data menggunakan kuisioner dengan menggunakan metode kuantitatif. Metode analisis data menggunakan analisis regresi linear berganda dengan bantuan aplikasi spss versi 25. Hasil penelitian ini menunjukkan bahwa (1) persepsi pelaku usaha mikro kecil dan menengah berpengaruh positif dan signifikan terhadap penggunaan informasi akuntansi khususnya sektor kuliner di Kota Kendari. (2) pengetahuan akuntansi berpengaruh positif dan signifikan terhadap penggunaan informasi akuntansi khususnya sektor kuliner di Kota Kendari .(3) persepsi pelaku usaha mikro kecil dan menengah dan pengetahuan akuntansi berpengaruh secara simultan terhadap penggunaan informasi akuntansi.
Identification and validation of SHC1 and FGFR1 as novel immune-related oxidative stress biomarkers of non-obstructive azoospermia
Authors: Pan Yang , Chen Xiangyu , Zhou Hang , Xu Mingming , Li Yuezheng , Wang Qihua , Xu Zhunan , Ren Congzhe , Liu Li , Liu Xiaoqiang 
Published: September 2024

BackgroundNon-obstructive azoospermia (NOA) is a major contributor of male infertility. Herein, we used existing datasets to identify novel biomarkers for the diagnosis and prognosis of NOA, which could have great significance in the field of male infertility.MethodsNOA datasets were obtained from the Gene Expression Omnibus (GEO) database. CIBERSORT was utilized to analyze the distributions of 22 immune cell populations. Hub genes were identified by applying weighted gene co-expression network analysis (WGCNA), machine learning methods, and protein–protein interaction (PPI) network analysis. The expression of hub genes was verified in external datasets and was assessed by receiver operating characteristic (ROC) curve analysis. Gene set enrichment analysis (GSEA) was applied to explore the important functions and pathways of hub genes. The mRNA–microRNA (miRNA)–transcription factors (TFs) regulatory network and potential drugs were predicted based on hub genes. Single-cell RNA sequencing data from the testes of patients with NOA were applied for analyzing the distribution of hub genes in single-cell clusters. Furthermore, testis tissue samples were obtained from patients with NOA and obstructive azoospermia (OA) who underwent testicular biopsy. RT-PCR and Western blot were used to validate hub gene expression.ResultsTwo immune-related oxidative stress hub genes (SHC1 and FGFR1) were identified. Both hub genes were highly expressed in NOA samples compared to control samples. ROC curve analysis showed a remarkable prediction ability (AUCs &gt; 0.8). GSEA revealed that hub genes were predominantly enriched in toll-like receptor and Wnt signaling pathways. A total of 24 TFs, 82 miRNAs, and 111 potential drugs were predicted based on two hub genes. Single-cell RNA sequencing data in NOA patients indicated that SHC1 and FGFR1 were highly expressed in endothelial cells and Leydig cells, respectively. RT-PCR and Western blot results showed that mRNA and protein levels of both hub genes were significantly upregulated in NOA testis tissue samples, which agree with the findings from analysis of the microarray data.ConclusionIt appears that SHC1 and FGFR1 could be significant immune-related oxidative stress biomarkers for detecting and managing patients with NOA. Our findings provide a novel viewpoint for illustrating potential pathogenesis in men suffering from infertility.
Investigating the role and regulation of GPNMB in progranulin-deficient macrophages
Authors: Gillett Drew A. , Neighbarger Noelle K. , Cole Cassandra , Wallings Rebecca L. , Tansey Malú Gámez 
Published: September 2024

IntroductionProgranulin (PGRN) is a holoprotein that is internalized and taken to the lysosome where it is processed to individual granulins (GRNs). PGRN is critical for successful aging, and insufficient levels of PGRN are associated with increased risk for developing neurodegenerative diseases like AD, PD, and FTD. A unifying feature among these diseases is dysregulation of peripheral immune cell populations. However, considerable gaps exist in our understanding of the function(s) of PGRN/GRNs in immune cells and their role in regulating central-peripheral neuroimmune crosstalk. One of the most upregulated genes and proteins in humans with GRN haploinsufficiency and in aged Grn knock-out (KO) mice is glycoprotein non-metastatic B (GPNMB) but its normal role within the context of immune crosstalk has not been elucidated.MethodsTo address this gap, peritoneal macrophages (pMacs) from 5-to-6-month old WT and Grn KO mice were assessed for Gpnmb expression and stimulation-dependent cytokine release in the presence or absence of the Gpnmb extracellular domain (ECD). Cellular localization, as well as inhibition of, the microphthalmia-associated transcription factor (MITF) was assessed to determine its mechanistic role in Gpnmb overexpression in Grn KO pMacs.ResultsWe observed an increase in GPNMB protein and mRNA as a result of insufficient progranulin in peripheral immune cells at a very early age relative to previous reports on the brain. Stimulation-dependent cytokine release was decreased in the media of Grn KO pMacs relative to WT controls; a phenotype that could be mimicked in WT pMacs with the addition og GPNMB ECD. We also found that MITF is dysregulated in Grn KO pMacs; however, its nuclear translocation and activity are not required to rescue the immune dysregulation of Grn KO macrophages, suggesting redundancy in the system.DiscussionThese findings highlight the fact that knowledge of early-stage disease mechanism(s) in peripheral populations may inform treatment strategies to delay disease progression at an early, prodromal timepoint prior to development of neuroinflammation and CNS pathology.
Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study
Authors: Tanimura Kenji , Saito Shigeru , Tsuda Sayaka , Ono Yosuke , Deguchi Masashi , Nagamatsu Takeshi , Fujii Tomoyuki , Nakatsuka Mikiya , Kobashi Gen , Arase Hisashi , Yamada Hideto 
Published: September 2024

IntroductionAnti-β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA)-DR antibodies may be a risk factor for recurrent pregnancy loss (RPL). The therapeutic modality for women with RPL and anti-β2GPI/HLA-DR antibody positivity has not been evaluated. This prospective, multicenter, observational study aimed to assess whether low-dose aspirin (LDA) and/or heparin therapies improve pregnancy outcomes in women with RPL who tested positive for anti-β2GPI/HLA-DR antibodies.MethodsBetween August 2019 and December 2021, 462 women with RPL underwent anti-β2GPI/HLA-DR antibody measurements and risk assessments for RPL. Each attending physician decided the treatment modality for women with RPL who tested positive for anti-β2GPI/HLA-DR antibodies, and their pregnancy outcomes were followed up until December 2023. Finally, 47 pregnancies in 47 women with RPL and anti-β2GPI/HLA-DR antibody positivity were included in the analysis and were divided into two groups regarding whether they were treated with LDA and/or unfractionated heparin (UFH) (LDA/UFH group, n = 39) or with neither of them (non-LDA/non-UFH group, n = 8). The rates of live birth and pregnancy complications (i.e., preeclampsia and preterm delivery before 34 gestational weeks due to placental insufficiency) were compared between the two groups.ResultsThe live birth rate in the LDA/UFH group was higher than that in the non-LDA/non-UFH group (87.2% vs 50.0%, p = 0.03). The pregnancy complication rate in the LDA/UFH group was significantly lower than that in the non-LDA/non-UFH group (5.9% vs 50.0%, p = 0.048). Among 21 women who tested positive for anti-β2GPI/HLA-DR antibodies and had no other risk factors for RPL, the live birth rate in the LDA/UFH group (n = 14) was much higher than that in the non-LDA/non-UFH group (n = 7) (92.9% vs 42.9%, p = 0.03).DiscussionThis study, for the first time, demonstrated that LDA and/or UFH therapies are effective in improving pregnancy outcomes in women with RPL and aβ2GPI/HLA-DR antibody positivity.
Acute leukoencephalopathy associated with daratumumab treatment in POEMS syndrome: a case report
Authors: Steinegger Lukas , Nierobisch Nathalie , De Vere-Tyndall Anthony , Schreiner Bettina , Roth Patrick , Kappos Ludwig , Kana Veronika , Herwerth Marina 
Published: September 2024

ObjectivesDaratumumab, a monoclonal antibody against CD38, is increasingly used in the treatment of multiple myeloma, other hematological malignancies and autoimmune diseases. Little is known about its CNS toxicity. We present a case of a patient with POEMS syndrome (syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) who developed an acute leukoencephalopathy shortly after initiation of therapy with daratumumab.MethodsCase report following the CARE case report guidelinesResultsThe patient presented with symptoms of headache and diffuse worsening of a pre-existing tetraparesis. MRI showed a rapidly progressive leukoencephalopathy. Extensive diagnostic evaluation revealed no specific cause, suggesting the leukoencephalopathy to be caused by daratumumab.DiscussionOur report highlights a probably rare, but clinically significant adverse effect of daratumumab and underlines the necessity of raised vigilance for neurological side effects in patients treated with daratumumab.
Robot-assisted therapy in stratified intervention: a randomized controlled trial on poststroke motor recovery
Authors: Liu Yang , Cui Lijun , Wang Jixian , Xiao Zihao , Chen Zhi , Yan Jin , Niu Chuanxin M. , Xie Qing 
Published: September 2024

ObjectiveTo compare the effects of robot-assisted therapy with conventional therapy for accelerating stratified intervention in poststroke patients with upper limb dysfunction.BackgroundFor stroke survivors, recovery of upper extremity function remains a major challenge in rehabilitation. Literature has suggested that the rate of recovery may improve if treatments can be individualized to their clinical profiles. However, there still lack clinical evidence on how to create treatment tailored to individual patients. Robot-assisted Therapy (RT) provides a straightforward approach to adjustment of the assistance-resistance continuum for individual patients. In early Brunnstrom stages of recovery, patients benefit from assistance training, whereas in later stages the training is favored with resistance. Therefore, RT may enhance Conventional Therapy (CT) but the use of RT in stratified intervention has not been investigated. This study evaluated the possible benefit of adopting RT following a protocol of upper-limb training, which was stratified with the Brunnstrom stage of each individual.MethodsThis study was a single-blinded randomized controlled trial. A total of 53 patients with stroke were recruited and randomized into 2 groups (CT, n = 27, 3 dropped out and RT, n = 26, 2 dropped out). Both groups were trained once per day, 5 days per week for 4 weeks. The CT group received 30 min of conventional therapy; the RT group received 30 min of upper limb robot-assisted training. Patients were assessed at the beginning, week-2, and week-4 of the treatment. The outcome measures included the Fugl-Meyer Assessment Upper-Extremity (FMA-UE) and the Modified Barthel Index (MBI).ResultsAcross the 4-week intervention, participants in the RT group recovered 1.979 points of FMA-UE per week, compared to 1.198 points per week in the CT group (t94 = 3.333, p &lt; 0.01); the recovery rate was 0.781 points/week higher in the RT group than in the CT group. Moreover, the recovery of FMA-UE was faster in proximal joints (t94 = 3.199, p &lt; 0.01), and for patients in Brunnstrom Stage III (t34 = 2.526, p &lt; 0.05). The improvements in MBI were not significantly different between RT and CT.ConclusionRobot-assisted therapy showed initial evidence for the acceleration of post-stroke recovery of motor function in the upper limb. Initial observations suggested that patients in Brunnstrom recovery stage III might benefit the most from the stratified intervention assisted by robotics.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=61834, Identifier [ChiCTR2000039010]. Registered 13 March 2020.
Nutritional status and dietary habits in older adults with fixed implant dental prostheses: a case-control study
Authors: Homsi George , Trulsson Mats , Grigoriadis Anastasios , Kumar Abhishek 
Published: September 2024

AimTo evaluate the nutritional status, nutritional risk, and dietary habits of patients treated with bimaxillary implant-supported fixed prostheses in comparison with a group of natural dentate patients.MethodsA study group (n = 25, 8 women, mean age = 70.6 ± 7.5 years) with bimaxillary implant-supported fixed prostheses and a control group (n = 25, 13 women, mean age = 69.0 ± 5.3) with a mean of 27.7 ± 1.8 natural teeth were recruited. The nutritional status and nutritional risk of the participants were evaluated with Mini Nutritional Assessment (MNA) and Seniors in the Community: Risk Evaluation for Eating and Nutrition; (SCREEN-14), while the dietary habits were recorded by data from a three-day dietary record. The data were analyzed with the Mann–Whitney U-test and independent t-test to evaluate the differences between the groups.ResultsThe results showed that although both the groups had normal nutrition status as revealed by the MNA scores the study group showed significantly higher BMI (p = 0.005) but lower SCREEN-14 (p = 0.012) scores, than the control group. The results also showed that higher SCREEN-14 scores were significantly associated with higher odds of being in the control group, with an odds ratio of 1.159 (p = 0.024). Further, the results of the analysis of the dietary records showed that the participants in the study group consumed fewer meals (p = 0.006) and fewer varieties of food (p &lt; 0.001), particularly fewer fruits (p = 0.011) than the control group.ConclusionThe results indicate that people with fixed implant prostheses may be susceptible to nutritional deficiencies according to the SCREEN-14 scores compared to their natural dentate counterparts. Further, people with implant prostheses also tend to have higher BMI and consume a smaller variety of foods, especially fruits, than the natural dentate control group.
Value of the lung immune prognostic index in patients with advanced small cell lung cancer treated with programmed death-ligand 1 and programmed death-1 inhibitors in the Chinese alpine region
Authors: Zhang Meiling , Hao Jingwei , Wu Yunjiao , Gao Ziyi , Wang Meng 
Published: September 2024

PurposeTo assess the potential added value of the lung immune prognostic index (LIPI) in patients with small cell lung cancer (SCLC), treated with programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) inhibitors, who lived in the Chinese alpine region.Methods120 SCLC patients treated with PD-L1/PD-1 inhibitors were divided into three LIPI groups, from July 2018 to April 2021. Cox regression models were used to evaluate the prognostic effect of three LIPI groups on overall survival (OS) and progression-free survival (PFS). Logistic regression analysis was conducted to explore the association between immune-related adverse events (irAEs) and the pretreatment of neutrophil-to-lymphocyte ratio (dNLR), lactate dehydrogenase (LDH), and LIPI.ResultsThe median OS was 4.5, 6.3, and 10.0 months (p=0.001) and the median PFS was 2.5, 4.3, and 5.3 months (p=0.049) for Poor, Intermediate, and Good LIPI, respectively. The disease control rate (DCR) was also higher in the Good LIPI group (p=0.003). Moreover, multivariate analysis confirmed that worse LIPI was correlated with shorter OS and PFS. dNLR was associated with the onset of irAEs, not LIPI. Conclusion: The LIPI might be a promising predictive and prognostic biomarker in SCLC patients treated with PD-L1/PD-1 inhibitors in the Chinese Alpine region.
Spillover of sustainable routines from work to private life: application of the Identity and Practice Interdependence Framework
Authors: Frezza Marcia 
Published: September 2024

IntroductionSpillover of sustainable routines and environmentally-responsible behaviors from one setting to another may contribute to achieving essential sustainability goals. Several previous studies on this topic have found few examples of spillover and have focused primarily on individual influences, indicating the need for a better understanding of the factors that have an impact on whether, how, and when spillover occurs. To this end, a novel conceptualization examining the interactions between identity principles and socio-material elements, the Identity and Practice Interdependence Framework, was applied to investigate the occurrence of spillover of sustainable routines from the workplace to home.MethodsThree focus groups totaling 30 employees of a major Brazilian steel-producing company, interviews in 15 employee homes, and on-site observations of work and private domains provided data that was analyzed qualitatively, using a deductive reflexive thematic approach.ResultsParticipants identified 58 changes in home routines related to sustainability as resulting from their experiences at work. With the consistent availability of practice elements (materials, competencies, meanings), learning about, witnessing and performing sustainable routines at work favored satisfactory levels of identity principles (self-efficacy, self-esteem, distinctiveness, continuity). Analysis suggested that seeking the same satisfactions of identity principles outside the workplace led individuals to adapt, change, and/or create more environmentally-responsible routines in their homes.DiscussionThe Identity and Practice Interdependence Framework permitted investigation of the integration of socio-material aspects with the role of individuals in the process of spillover, and indicated some ways they may interact. Both the provision of socio-material components in the first setting and the recognition of more sustainable routines as a feasible path to satisfaction of identity principle needs contribute to individual engagement and persistence in the second setting. Consistent and frequent experiences with more sustainable routines in the first setting or situation may be key to creating this expectation, and therefore to the occurrence of spillover to another setting. The framework complements previous approaches by allowing for a more complex analysis of spillover, which can be used to enrich research on sustainable practices and help promote environmentally-friendly behaviors and sustainable routines, or other desired outcomes, both within organizations and beyond.
Tools for screening maternal mental health conditions in primary care settings in sub-Saharan Africa: systematic review
Authors: Gyimah Leveana , Agyepong Irene Akua , Owiredu David , Awini Elizabeth , Yevoo Linda Lucy , Ashinyo Mary Eyram , Aye Sorre Grace Emmanuelle Victoire , Abbas Shazra , Cronin de Chavez Anna , Mirzoev Tolib , Danso-Appiah Anthony 
Published: September 2024

IntroductionIn sub-Saharan Africa, pregnant and postpartum women with mental health problems are often missed in healthcare systems. To address this, a practical and simple screening tool for maternal mental health should be available to primary healthcare workers. An important step toward having such a tool is to assess the existing tools and their effectiveness in primary care settings.MethodsWe systematically searched PubMed, LILAC, CINAHL, Google Scholar, African Index Medicus, HINARI, and African Journals Online from inception to 31 January 2023, without language restriction. Reference lists of retrieved articles were reviewed and experts in the field were contacted for studies not captured by our searches. All retrieved records were collated in Endnote, de-duplicated, and exported to Rayyan for screening. Study selection and data extraction were done by at least two reviewers using a pre-tested flow chart and data extraction form. Disagreements between reviewers were resolved through discussion. We contacted primary authors for missing or insufficient information and conducted a content analysis of the psychometric properties of the tools.ResultsIn total, 1,181 studies were retrieved by our searches, of which 119 studies were included in this review. A total of 74 out of 119 studies (62%) were screened for depression during pregnancy and or the postpartum period. The Edinburg Postpartum Depression Scale (EPDS) and the Patient Health Questionnaire (PHQ-9) were the most commonly used tools. In total, 12 studies reported specificity and sensitivity for tools for measuring depression (EPDS, PHQ-9, and Whooley) and psychological distress [Self Report Questionnaire (SRQ) and Kessler Psychological Distress Scale (KPDS)]. The average sensitivity and specificity of the EPDS reported were 75.5 and 76.5%, respectively, at a cut-off of ≥13. The EPDS appears to be the most acceptable, adaptable, user-friendly, and effective in screening for maternal mental health conditions during pregnancy and postpartum. However, the methodological approach varied for a particular tool, and documentation on the attributes was scanty.ConclusionThe EPDS was the most commonly used tool and considered as most acceptable, adaptable, user-friendly, and effective. Information on the performance and psychometric properties of the vast majority of screening tools was limited.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022323558, identifier CRD42022323558 (PROSPERO).