bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis
Authors: Hwang Soyun M. , Feigenson Marina , Begun Dana L. , Shull Lomeli Carpio , Culley Kirsty L. , Otero Miguel , Goldring Mary B. , Ta Lauren E. , Kakar Sanjeev , Bradley Elizabeth W. , Westendorf Jennifer J. 
Published: October 2017

ABSTRACTPhlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis. Mice lacking Phlpp1 were previously shown to be resistant to post‐traumatic osteoarthritis. Here a small molecule with therapeutic properties that inhibits Phlpp1 and Phlpp2 was tested for its ability to slow post‐traumatic OA in mice and to stimulate anabolic pathways in human articular cartilage from OA joints. PTOA was induced in male C57Bl/6 mice by surgically destabilizing the meniscus. Seven weeks after surgery, mice received a single intra‐articular injection of the Phlpp inhibitor NSC117079 or saline. Mechanical allodynia was measured with von Frey assays, mobility was tracked in an open field system, and cartilage damage was assessed histologically. A single intra‐articular injection of the Phlpp inhibitor NSC117079 attenuated mechanical allodynia and slowed articular cartilage degradation in joints with a destabilized meniscus. Animals treated with the Phlpp inhibitor 7 weeks after injury maintained normal activity levels, while those in the control group traveled shorter distances and were less active 3 months after the joint injury. NSC117079 also increased production of cartilage extracellular matrix components (glycosaminoglycans and aggrecan) in over 90% of human articular cartilage explants from OA patients and increased phosphorylation of Phlpp1 substrates (AKT2, ERK1/2, and PKC) in human articular chondrocytes. Our results indicate that Phlpp inhibitor NSC117079 is a novel osteoarthritis disease modifying drug candidate that may have palliative affects. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1487–1497, 2018.
Quantifying changes and influences on mottled duck density in Texas
Authors: Ross Beth E. , Haukos David A. , Walther Patrick 
Published: October 2017

ABSTRACTUnderstanding the relative influence of environmental and intrinsic effects on populations is important for managing and conserving harvested species, especially those species inhabiting changing environments. Additionally, climate change can increase the uncertainty associated with management of species in these changing environments, making understanding factors affecting their populations even more important. Coastal ecosystems are particularly threatened by climate change; the combined effects of increasing severe weather events, sea level rise, and drought will likely have non‐linear effects on coastal marsh wildlife species and their associated habitats. A species of conservation concern that persists in these coastal areas is the mottled duck (Anas fulvigula). Mottled ducks in the western Gulf Coast are approximately 50% below target abundance numbers established by the Gulf Coast Joint Venture for Texas and Louisiana, USA. Although evidence for declines in mottled duck abundance is apparent, specific causes of the decrease remain unknown. Our goals were to determine where the largest declines in mottled duck population were occurring along the system of Texas Gulf Coast National Wildlife Refuges and quantify the relative contribution of environmental and intrinsic effects on changes to relative population density. We modeled aerial survey data of mottled duck density along the Texas Gulf Coast from 1986–2015 to quantify effects of extreme weather events on an index to mottled duck density using the United States Climate Extremes Index and Palmer Drought Severity Index. Our results indicate that decreases in abundance are best described by an increase in days with extreme 1‐day precipitation from June to November (hurricane season) and an increase in drought severity. Better understanding those portions of the life cycle affected by environmental conditions, and how to manage mottled duck habitat in conjunction with these events will likely be key to persistence of the species under future environmental conditions. © 2017 The Wildlife Society.
Health disparities among adults with voice problems in the United States
Authors: Hur Kevin , Zhou Sheng , Bertelsen Caitlin , Johns Michael M. 
Published: October 2017

ObjectiveTo assess differences in access to care and healthcare utilization among adults who reported voice problems in 2012.Study DesignCross‐sectional study.MethodsThe 2012 National Health Interview Survey was utilized to evaluate adults who had a “voice problem in the past 12 months.” Multivariate analyses determined the influence of sociodemographic variables on the prevalence of voice problems in adults and access to care.ResultsAmong 243 million adults in the United States, 17.9 ± 0.05 million adults (7.63% ± 0.21%) report experiencing voice problems. After controlling for age, education, income level, geographic region, and health insurance status, African Americans (odds ratio [OR]: 0.83, P < 0.05), Hispanics (OR: 0.61, P < 0.01), and other minorities (OR: 0.69, P < 0.01) had a lower OR for reporting voice problems in the last year relative to white adults. Among adults with voice problems, Hispanics were more likely to delay care because they could not reach a medical office by telephone (OR: 1.85, P < 0.01) and due to long wait times at the doctor's office (OR: 2.04, P < 0.01) compared to white adults. Adults with voice problems who were a racial minority, low income, or had public health insurance were more likely to postpone care because they lacked a mode of transportation.ConclusionTargeted programs are necessary to address the health disparities and barriers to care among those who suffer from voice problems.Level of EvidenceIV. Laryngoscope, 128:915–920, 2018
High Resolution Mass Spectrometric Analysis of Secoiridoids and Metabolites as Biomarkers of Acute Olive Oil Intake—An Approach to Study Interindividual Variability in Humans
Authors: Silva Sandra , Garcia‐Aloy Mar , Figueira Maria Eduardo , Combet Emilie , Mullen William , Bronze Maria Rosário 
Published: October 2017

ScopePhenolic compounds are minor components of extra virgin olive oil (EVOO). Secoiridoids are the major components contributing to the phenolic content of EVOO. Information is lacking regarding their potential as biomarkers for EVOO intake.Methods and resultsHealthy volunteers (n = 9) ingested 50 mL of EVOO in a single dose containing 322 mg kg−1 total phenolic content (caffeic acid equivalents) and 6 mg 20 g−1 hydroxytyrosol and its derivatives. Plasma is collected before (0 h) and at 0.5, 1, 2, 4, and 6 h after ingestion. Urine samples are collected prior to ingestion (0 h) and at 0–4, 4–8, 8–15, and 15–24 h. Samples are analyzed by UPLC coupled with an Exactive Orbitrap MS. Partial least squares discriminant analysis with orthogonal signal correction is applied to screen for metabolites that allow sample discrimination. Plasma biomarkers and urine biomarkers are selected although individual variability is observed among volunteers. Results are in accordance with in vitro experiments performed (in vitro digestion and hepatic microsomal activity assays).ConclusionsPlasma (elenolic acid + H2; p‐HPEA‐EA + H2 + glucuronide) and urinary (3,4‐DHPEA‐EA, 3,4‐DHPEA‐EA + H2+glucuronide, methyl 3,4‐DHPEA‐EA + H2+glucuronide) secoiridoid compounds are selected as biomarkers to monitor EVOO intake showing good predictive ability according to multivariate analysis.
Removal of organic water pollutant using magnetite nanomaterials embedded with ionic copolymers of 2‐acrylamido‐2‐methylpropane sodium sulfonate cryogels
Authors: Al‐Hussain Sami A , Ezzat Abdelrhman O , Gaffer Amany K , Atta Ayman M 
Published: October 2017

AbstractMagnetite cryogel composites as macroporous crosslinked matrices have received wide attention and attract much interest in the water purification and desalination industry. They can be used to produce effective adsorbents with high adsorption rate, capacity and desorption for water pollutants. In this work, the incorporation of magnetite nanoparticles into cryogels by the in situ method is proposed to increase the dispersion of nanoparticles in the gel composites and to produce effective magnetic materials with high adsorption capacities. Ionic sodium‐2‐acrylamido‐2‐methylpropane sulfonate (Na‐AMPS) monomer was selected to prepare cryogels as the homopolymer or copolymers with 2‐hydroxyethyl methacrylate (HEMA) or N‐vinyl pyrrolidone (VP) by the crosslinking polymerization technique in the frozen state. Magnetite nanoparticles were introduced into the cryogel by the in situ co‐precipitation method after introducing iron cations into the cryogel networks. The surface morphologies, crystal structure, magnetite content, thermal stability and magnetic properties were determined for the cryogels and their magnetite composites. The magnetite cryogel composites show significantly enhanced methylene blue dye removal in short times with higher adsorption efficiencies and good regeneration to form an effective adsorbent for water treatment. © 2017 Society of Chemical Industry
Using the SAPAS to identify risk for personality disorders among psychiatric outpatients in India: A feasibility study
Authors: Innocent Simeon , Podder Priyanka , Ram Jai Ranjan , Barnicot Kirsten , Sen Piyal 
Published: October 2017

AbstractPersonality disorders (PDs) are common among psychiatric outpatients and are associated with increased morbidity and worse treatment outcomes. Epidemiological research conducted among this population in Asian countries is limited, reflecting a significant gap in the current literature. One barrier to this research is the lack of appropriate screening tools. The current research assessed the feasibility of using the SAPAS (Standardized Assessment of Personality–Abbreviated Scale) screening tool to identify individuals at high risk of PD in an Indian psychiatric outpatient population and provides an initial estimate of PD prevalence by using a validated diagnostic interview, the ICD‐10 International Personality Disorder Examination.The findings suggest that whilst use of the SAPAS was feasible, acceptable to patients and led to clinically useful findings, when using the recommended cut‐off score of 4, the SAPAS largely overdiagnoses the risk for PD in psychiatric outpatients in India (positive predictive value = 26.3%). The estimated prevalence of personality disorder in the sample was 11.1%, based on administering the International Personality Disorder Examination diagnostic interview to high‐risk patients scoring 4 and above on the SAPAS, which is higher than previous estimates for this population and still likely to be an underestimation. Future studies should translate the measure into Bengali and evaluate its sensitivity and specificity at different cut‐off points in order to optimize its use in Indian populations. Copyright © 2017 John Wiley & Sons, Ltd.
Posterior reversible encephalopathy syndrome (PRES) induced by pazopanib, a multi-targeting tyrosine kinase inhibitor, in a patient with soft-tissue sarcoma: case report and review of the literature
Authors: Deguchi Shoichi , Mitsuya Koichi , Nakasu Yoko , Hayashi Nakamasa , Katagiri Hirohisa , Murata Hideki , Wasa Junji , Takahashi Mitsuru , Endo Masahiro 
Published: October 2017

SummaryPosterior reversible encephalopathy syndrome (PRES) is a clinical entity characterized by acute neurological symptoms such as severe headache, seizures, and visual disturbance, and by typical reversible lesion on brain magnetic resonance (MR) images. Since PRES is thought to be caused by vascular endothelial injury due to cytotoxic agents or acute systemic hypertension, the number of reports on PRES associated with angiogenesis inhibitors has been increasing. Although five cases that developed PRES due to pazopanib for renal cell carcinoma have already been reported, none of PRES due to pazopanib for soft-tissue sarcoma has been reported thus far. We describe a case of a 49-year-old woman with retroperitoneal soft-tissue sarcoma who developed PRES during pazopanib administration. Pazopanib at 800 mg/day was administered as her third-line treatment at relapse. After 38 days of pazopanib, she was admitted to our hospital with severe headache, vomiting, and systemic hypertension. The next day, she developed consciousness deterioration and visual disturbance together with exacerbated systemic hypertension. Brain MR images revealed hyper-intense signals on FLAIR sequences in the bilateral occipital lobes and the left thalamus. Intravenous nicardipine injection was immediately started to control her blood pressure and pazopanib was discontinued. Her symptoms gradually improved and disappeared on the fifth hospital day. After 2 weeks, hyper-intense signals on a FLAIR sequence disappeared completely. She restarted a low dose of pazopanib under good blood pressure control and experienced no subsequent recurrence of PRES.
Effect of arc–current and spray distance on elastic modulus and fracture toughness of plasma-sprayed chromium oxide coatings
Authors: Kar Simanchal , Bandyopadhyay Partha Pratim , Paul Soumitra 
Published: October 2017

Abstract
In this experimental study, chromium oxide powder was sprayed on a low-carbon steel substrate using the atmospheric plasma spray process. The current and standoff distances (SODs) were varied to study their effect on the fracture toughness of the coatings. Theoretically, as the arc current increases, the melting of the ceramic oxide should increase and this in turn should lead to the formation of a dense coating. However, it was observed that if the arc power is too high and because the particle size of the powder is small (approximately 30 μm), the particles tend to fly away from the plasma core. Similarly, an appropriate SOD should provide the particles with more melting time, thus resulting in a dense coating. On the other hand, a larger SOD leads to the solidification of the molten particles before the droplets can reach the substrate. All these effects may lead to substantial variation in the fracture toughness of the coating. The present paper attempts to correlate the plasma spraying parameters and microstructure of the coating with the fracture toughness and other primary coating properties.
Leveraging leader–leader exchange to enrich the effect of leader–member exchange on team innovation
Authors: Yang Jaewan 
Published: October 2017

AbstractIn this study, I propose supervisors’ upward leader–leader exchange relationships as an important boundary condition for the relationship between average leader–member exchange (LMX) relationships and a climate for innovation support at the group level. Specifically, I argue that the effect of resource spillover to poor-LMX subordinates within a work group is an important mechanism that leads to the development of a climate that supports innovation. I test the hypothesized moderated-mediation model by using multisource and multiwave data collected from 590 employees and 75 supervisors. The findings indicate that the indirect effect of team LMX relationships on team effectiveness via a climate for innovation support is more positive under high conditions of leader–leader exchange, whereas the effect is less positive under low conditions of leader–leader exchange. Implications and limitations relevant to developing research around LMX and innovation are addressed.
Validation of analytical method and evaluation of clothianidin residues in rice in a typical Chinese field ecosystem
Authors: ZHANG Z. Y. , ZHENG Z. T. , ZHU G. Y. , YU X. Y. , WANG D. L. , LIU X. J. 
Published: October 2017

SUMMARYA liquid chromatography mass spectrometry method for determination of clothianidin in brown rice, straw, rice hull, paddy water and paddy sediment was developed and residue levels were determined in the different components. The limit of quantification was set at 0·01 mg/kg for the matrices studied. Clothianidin degradation in straw, paddy water and soil was studied, and clothianidin residues in brown rice, straw, hull and paddy soil were determined. Concurrent recoveries were between 85·6 and 92·5%, with relative standard deviations ranging from 1·3 to 6·8% at three fortification levels between 0·01 and 5·0 mg/kg. The half-lives in straw, paddy water and paddy sediment were found to be 1·9–4·9, 4·1–5·0 and 4·9–6·3 days, respectively. The maximum residues in brown rice, straw, hull and paddy soil samples were 0·38, 1·88, 1·38 and 0·14 mg/kg, respectively.
Polygenic risk for schizophrenia, transition and cortical gyrification: a high-risk study
Authors: Neilson E. , Bois C. , Clarke T.-K. , Hall L. , Johnstone E. C. , Owens D. G. C. , Whalley H. C. , McIntosh A. M. , Lawrie S. M. 
Published: October 2017

AbstractBackgroundSchizophrenia is a highly heritable disorder, linked to several structural abnormalities of the brain. More specifically, previous findings have suggested that increased gyrification in frontal and temporal regions are implicated in the pathogenesis of schizophrenia.MethodsThe current study included participants at high familial risk of schizophrenia who remained well (n= 31), who developed sub-diagnostic symptoms (n= 28) and who developed schizophrenia (n= 9) as well as healthy controls (HC) (n= 16). We first tested whether individuals at high familial risk of schizophrenia carried an increased burden of trait-associated alleles using polygenic risk score analysis. We then assessed the extent to which polygenic risk was associated with gyral folding in the frontal and temporal lobes.ResultsWe found that individuals at high familial risk of schizophrenia who developed schizophrenia carried a significantly greater burden of risk-conferring variants for the disorder compared to those at high risk (HR) who developed sub-diagnostic symptoms or remained well and HC. Furthermore, within the HR cohort, there was a significant and positive association between schizophrenia polygenic risk score and bilateral frontal gyrification.ConclusionsThese results suggest that polygenic risk for schizophrenia impacts upon early neurodevelopment to confer greater gyral folding in adulthood and an increased risk of developing the disorder.
INTERPOLATED SCHUR MULTIPLE ZETA VALUES
Authors: BACHMANN HENRIK 
Published: October 2017

Inspired by the recent work of M. Nakasuji, O. Phuksuwan and Y. Yamasaki, we combine interpolated multiple zeta values and Schur multiple zeta values into one object, which we call interpolated Schur multiple zeta values. Our main result will be a Jacobi–Trudi formula for a certain class of these new objects. This generalizes an analogous result for Schur multiple zeta values and implies algebraic relations between interpolated multiple zeta values.
The role of π-blocking hydride ligands in a pressure-induced insulator-to-metal phase transition in SrVO2H
Authors: Yamamoto Takafumi , Zeng Dihao , Kawakami Takateru , Arcisauskaite Vaida , Yata Kanami , Patino Midori Amano , Izumo Nana , McGrady John E. , Kageyama Hiroshi , Hayward Michael A. 
Published: October 2017

AbstractTransition-metal oxyhydrides are of considerable current interest due to the unique features of the hydride anion, most notably the absence of valence p orbitals. This feature distinguishes hydrides from all other anions, and gives rise to unprecedented properties in this new class of materials. Here we show via a high-pressure study of anion-ordered strontium vanadium oxyhydride SrVO2H that H− is extraordinarily compressible, and that pressure drives a transition from a Mott insulator to a metal at ~ 50 GPa. Density functional theory suggests that the band gap in the insulating state is reduced by pressure as a result of increased dispersion in the ab-plane due to enhanced Vdπ-Opπ-Vdπ overlap. Remarkably, dispersion along c is limited by the orthogonal Vdπ-H1s-Vdπ arrangement despite the greater c-axis compressibility, suggesting that the hydride anions act as π-blockers. The wider family of oxyhydrides may therefore give access to dimensionally reduced structures with novel electronic properties.
The introduction of the Barbier reaction into polymer chemistry
Authors: Sun Xiao-Li , Liu Dong-Ming , Tian Di , Zhang Xiao-Yun , Wu Wei , Wan Wen-Ming 
Published: October 2017

AbstractThe Barbier reaction, a widely utilized reaction for carbon–carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an organic halide and a benzoyl group, a series of phenylmethanol group containing polymers, including polymonophenylmethanol (PMPM), polydiphenylmethanol (PDPM), and polytriphenylmethanol (PTPM), have been synthesized. Para-PTPM exhibits interesting aggregation-induced emission, tunable thermo-responsive over a wide temperature range, sensory, luminescence enhancement of fluorescent dye in solid-state and processing properties. This significantly expands the libraries of monomer and polymer, and opens up an avenue for the design and application of functional polymer materials.
Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia
Authors: Hong Chang-Sook , Sharma Priyanka , Yerneni Saigopalakrishna S. , Simms Patricia , Jackson Edwin K. , Whiteside Theresa L. , Boyiadzis Michael 
Published: October 2017

AbstractExosomes, small (30–150 nm) extracellular vesicles (EVs) isolated from plasma of patients with acute myeloid leukemia (AML) carry leukemia-associated antigens and multiple inhibitory molecules. Circulating exosomes can deliver suppressive cargos to immune recipient cells, inhibiting anti-tumor activities. Pre-therapy plasma of refractory/relapsed AML patients contains elevated levels of immunosuppressive exosomes which interfere with anti-leukemia functions of activated immune cells. We show that exosomes isolated from pre-therapy plasma of the AML patients receiving adoptive NK-92 cell therapy block anti-leukemia cytotoxicity of NK-92 cells and other NK-92 cell functions. NK-92 cells do not internalize AML exosomes. Instead, signaling via surface receptors expressed on NK-92 cells, AML exosomes simultaneously deliver multiple inhibitory ligands to the cognate receptors. The signals are processed downstream and activate multiple suppressive pathways in NK-92 cells. AML exosomes reprogram NK-92 cells, interfering with their anti-leukemia functions and reducing the therapeutic potential of adoptive cell transfers. Plasma-derived exosomes interfere with immune cells used for adoptive cell therapy and may limit expected therapeutic benefits of adoptive cell therapy.