bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of six parametric Robinson and three parametric Howell's modification of Scarf-BloomRichardson grading method on breast aspirates with histopathology: A prospective study
Authors: Walke Vaishali A , Gunjkar Gajanan 
Published: December 2017

Background:
Fine needle aspiration cytology (FNAC) is a quick method to assess the tumor grade before its removal which will help clinicians to decide on the appropriate neo adjuvant therapy. This is essentially true in developing countries where core needle biopsy still is not used as a standard practice to sample breast carcinoma. Assessment of biological aggressiveness by cytological grading (CG) without removing the would be of immense value. The National Cancer Institute, Bethesda, sponsored conference had recommended that tumor grading on FNA material should be incorporated in cytology reports for prognostication.

Aim:
The present study was carried out to evaluate which among the two, five parametric Robinson or three parametric Scarf–BloomRichardson (SBR) cytology grading method corresponds better with the histological grading (HG) in breast carcinoma.

Materials and Methods:
FNAC of 150 cases of ductal carcinoma breast with subsequent histological confirmation was studied to assess the tumor grade on cytology by two distinct methods Robinson and Howell's modification of SBRmethod and then correlated with histologic grade.

Results:
Comparative analysis revealed concordance of 76% by Robinson and 68% by SBR with Kappa value of 0.6683 and 0.4505 and diagnostic accuracy of 86.7% and 78.7%, respectively.

Conclusions:
We conclude that Robinson method showed a better correlation and higher kappa value of agreement in comparison with SBR method. Robinson method of CG is simpler, objective, and easily reproducible for grading breast carcinomas.
Technique to stabilize Wax Occlusion Rims following Maxillomandibular Relationship Records
Authors: Shaikh Sameera , Nimbalkar Smita , Patil Pravinkumar 
Published: December 2017

ABSTRACT
Maxillomandibular relationship (MMR) recorded with the help of wax occlusion rims, with or without an interocclusal recording medium, tends to distort during the mounting procedure under higher room temperature. When the records were required to be transported to the distant laboratories for mounting, maintaining the sealed occlusion rims undistorted is always a concern to the prosthodontist. A simplified technique for stabilizing the MMR records made with wax occlusion rims is described. This technique is easy to perform and no special instruments or materials are required. The records stabilized with this technique remain undistorted till mounting even under high room temperature and can safely be transported to the distant laboratories for mounting.

How to cite this article
Patil P, Nimbalkar S, Shaikh S. Technique to stabilize Wax Occlusion Rims following Maxillomandibular Relationship Records. Int J Prosthodont Restor Dent 2017;7(4):114-116.
Effect of Relief at the Median Palatal Plate on Denture-supporting Ability
Authors: Tanaka Satomi , Sato Yuji , Kitagawa Noboru , Shimodaira Osamu , Isobe Akio , Takamatsu Naoya , Omori Tomoka 
Published: December 2017

ABSTRACT

Aim
A new maxillary palatal plate-form device that simultaneously measures clenching force and subsidence of the palatal mucosa at the onset of jaw clenching pain was developed to ascertain the effect of median palatal plate relief on denture-bearing ability.

Materials and methods
In 15 dentulous subjects, pseudo-palatal plates were affixed to the palatal mucosa; anterior splints were affixed as maxillary references for measuring subsidence upon transmission of the clenching force through a pressurizing splint affixed to the mandible. The relief at the median palatal plate was categorized as: No-relief, 0.23 mm relief, and 0.46 mm relief. Subjects clenched their jaws until they experienced pain. The clenching force and subsidence of the palatal mucosa were simultaneously measured and compared across relief categories, and their relationship to the extent of relief at the onset of pain was evaluated.

Results
At the onset of pain, both clenching force and subsidence of the palatal mucosa in the relief conditions were significantly greater than those in the no-relief condition (p < 0.05). In some patients, both clenching force and subsidence of the palatal mucosa decreased with increase in relief.

Conclusion
Relief at the median palatal plate effectively increases the bearing ability of the palatal part. However, the range and extent of relief might vary, depending on oral conditions.

Clinical significance
Using this approach, the relief area of maxillary full dentures suitable for individual patients was determined in an objective and convenient manner and the accuracy of denture treatments was improved. This could improve the quality of life of patients wearing dentures.

How to cite this article
Tanaka S, Sato Y, Kitagawa N, Shimodaira O, Isobe A, Takamatsu N, Omori T. Effect of Relief at the Median Palatal Plate on Denture-supporting Ability. Int J Prosthodont Restor Dent 2017;7(4):117-123.
Relación altura-diámetro en tres especies cultivadas en una plantación forestal comercial en el Este tropical de México
Authors: Castillo-Gallegos Epigmenio , Jarillo-Rodríguez Jesús , Escobar-Hernández Ramiro 
Published: December 2017

Introducción: El diámetro a la altura de pecho y la altura son las principales variables medidas en los inventarios forestales, ya que ayudan en el proceso de toma de decisiones para el manejo de plantaciones forestales y en investigaciones sobre modelos de crecimiento. Objetivo: Encontrar la función matemática que mejor relacione el diámetro a la altura del pecho (DAP, aproximadamente 1.3 m) y la altura (h) de tres especies forestales cultivadas en el mismo terreno: aguacate silvestre (Cinnamomum sp.), pino blanco chiapaneco (Pinus chiapensis [Martínez] Andresen) y cedro blanco o piocho (Melia azedarach L.). Materiales y métodos: Se compararon 22 modelos no lineales: 13 con dos parámetros y nueve con tres parámetros, usando la diferencia del criterio de información de Akaike corregido (AICc). Resultados y discusión: Los mejores modelos fueron: la hipérbola de dos parámetros para aguacate silvestre (h = (17.58*DAP)/(12.33 + DAP), R2 = 0.79, EEE = 0.80, n = 647); la función de Richards de tres parámetros para pino blanco chiapaneco (h = 10.14*(1 – e-0.206*DAP)1.689, R2 = 0.35, EEE = 1.28, n = 664); y la función sigmoidea de Korf para piocho (H = 18.25*(e-2.46*(DAP-0.556)), R2 = 0.49, EEE = 0.96, n = 692). Conclusión: El mejor modelo fue distinto para cada especie. Los datos presentaron una dispersión alta a lo largo de la curva predicha, particularmente en pino blanco chiapaneco.
Crecimiento de Leucaena leucocephala (Lam.) de Wit biofertilizada con hongos micorrízicos arbusculares en vivero
Authors: Aguirre-Medina Juan F. , Gálvez-López Ana L. , Ibarra-Puón José C. 
Published: December 2017

Introducción: Leucaena leucocephala (Lam.) de Wit es nativa de América tropical. El sistema radical de la especie se asocia a microorganismos que mejoran la nutrición y el crecimiento. Objetivo: Evaluar el efecto de recolectas de hongos micorrízicos arbusculares (HMA) sobre el contenido de fósforo (P) y crecimiento de L. leucocephala en vivero. Materiales y métodos: Las semillas se sembraron y se aplicaron seis tratamientos: Rhizophagus intraradices (Schenck & Sm.) Walker & Schüßler (1), las recolectas “Caracoles” (2), “Rosario Izapa” (3), “Té limón” (4) y “San Rafael” (5), fertilización 15N-15P-15K (6) y un testigo. Las variables morfológicas y fisiológicas, colonización radical y contenido de P se registraron a los 120 días. Los datos se sometieron a un análisis de varianza y comparación de medias (Tukey, P ≤ 0.05). Resultados y discusión: Los HMA mejoraron las características de la planta en comparación con el testigo y la fertilización. Rhizophagus intraradices causó los valores más altos de crecimiento en la parte aérea, colonización micorrízica y contenido de P, y el menor crecimiento en el sistema radical. Los aislamientos “Caracoles” y “Rosario Izapa” promovieron altura, biomasa de la raíz y contenido de P más altos que “Té limón” y “San Rafael”. Conclusión: Los HMA permiten disminuir la fertilización química sin detrimento del crecimiento de L. leucocephala.
Reservorios y dinámica de nutrientes en dos rodales bajo aprovechamiento de Pinus montezumae Lamb. en Tlaxcala, México
Authors: López-Escobar Norma F. , Gómez-Guerrero Armando , Velázquez-Martínez Alejandro , Fierros-González Aurelio M. , Castruita-Esparza Luis U. , Vera-Castillo José A. G. 
Published: December 2017

Introducción: El estudio del ciclo de nutrientes es importante para proponer métodos de aprovechamiento sostenible en los bosques. Objetivos: Evaluar los reservorios de N, P, K, Ca y Mg en árboles, mantillo y suelo mineral de dos rodales de Pinus montezumae Lamb. bajo aprovechamiento; estimar la tasa de descomposición de mantillo; y cuantificar la cantidad anual de nutrientes demandada. Materiales y métodos: El estudio se realizó en Nanacamilpa, Tlaxcala. La biomasa y masa de nutrientes en el fuste, ramas y hojas se estimaron con un muestreo destructivo de 10 árboles. Resultados y discusión: Los datos dasométricos, reservorios y dinámica de nutrientes fueron similares en ambos rodales (t, P > 0.05). En el suelo mineral, los contenidos de N, P, K, Ca y Mg fueron 5 419, 68, 1 245, 9 163 y 2 029 kg·ha-1, respectivamente; y en la biomasa aérea fueron 242, 12, 28, 167 y 118 kg·ha-1, respectivamente. La tasa de descomposición de hojarasca fue -0.335. El arbolado requiere, para su crecimiento, 73 a 81 kg·ha-1·año-1 de N, 5.2 a 5.3 kg·ha-1·año-1 de P y 9.4 a 10 kg·ha-1·año-1 de K. Conclusión: Los nutrientes del suelo podrían mantener el crecimiento del bosque por 256 años, pero el P podría ser un limitante si las prácticas sustentables de cosecha se modifican.
Densidad máxima y diagrama de manejo de la densidad para bosques mezclados de Durango, México
Authors: Quiñonez-Barraza Gerónimo , Tamarit-Urias Juan C. , Martínez-Salvador Martín , García-Cuevas Xavier , De los Santos-Posadas Héctor M. , Santiago-García Wenceslao 
Published: December 2017

Introducción: La densidad del rodal impacta en la productividad y en la estructura y funciones de los bosques. Objetivos: Comparar las líneas de densidad máxima para bosques mezclados, ajustadas con mínimos cuadrados ordinarios (MCO) y regresión frontera estocástica (RFE), y generar un diagrama de manejo de la densidad (DMD) para prescribir aclareos. Materiales y métodos: Los datos se obtuvieron en rodales mezclados de la Unidad de Manejo Forestal 1005 “Santiago Papasquiaro y Anexos” en Durango, México. La relación funcional densidad-tamaño se estableció con el modelo de Reineke. La línea de densidad máxima se ajustó con MCO y RFE, este último con los enfoques seminormal (N-H), normal-exponencial (N-E) y normal-truncada (N-T). El DMD se construyó con la ecuación de RFE con el enfoque de distribución normal-truncada. Resultados y discusión: La línea de densidad máxima, modelada vía RFE con enfoque N-T, mostró mejor ajuste al límite superior de la densidad máxima de los datos de rodales mezclados. El DMD sugiere que los aclareos para estos rodales pueden aplicarse con intensidades de corta altas, a pesar de las prácticas convencionales, donde raramente se remueve más del 30 % del área basal o volumen. Conclusión: La línea de densidad máxima para bosques mezclados de Durango, México, se generó objetivamente con regresión frontera estocástica, como un modelo normal-truncado.
PROGRESSIVIDADE DO IMPOSTO DE RENDA DA PESSOA FÍSICA NO BRASIL: REALIDADE OU MITO?
Authors: Canuto Coelho André Felipe , Borba Bruna Estima 
Published: December 2017

O corrente artigo tem por objetivo demonstrar o baixo grau de concretização dos princípios da isonomia tributária e da capacidade econômica do imposto de renda da pessoa física (IRPF) no Brasil sob a ótica da progressividade. Utilizando metodologia de pesquisa qualitativa e método indutivo, parte-se do estudo do significado e da efetividade da progressividade do IRPF, associando-a aos princípios da isonomia e da capacidade econômica. Conclui-se que há reduzido grau de progressividade na incidência do IRPF, em razão de tratamento favorecido e não progressivo dispensado aos rendimentos de capital em detrimento dos rendimentos do trabalho. Dados históricos demonstram ainda a mitigação deste atributo em razão da redução da quantidade de faixas e da diferença entre os limites máximo e mínimo das alíquotas.
Impact of Light Excitation on Liquid Gate‐All‐Around Silicon Nanowire Field‐Effect Transistor Biosensors with Bowtie Antenna
Authors: Zhang Yongqiang , Li Kai , Boichuk Nazarii , Pustovyi Denys , Chekubasheva Valeriia , Long Hanlin , Petrychuk Mykhailo , Vitusevich Svetlana 
Published: October 2024

AbstractRecently it is shown that sensitivity of biosensors can be considerably improved using single trap phenomena resulting in two‐level random telegraph signal (RTS) switching in current. To develop the transistor structure with a predefined trap position using gold antenna is suggested, which can be excited by light of different intensities to influence the properties of the underlying dielectric layer. High‐quality liquid gate‐all‐around (LGAA) silicon nanowire (NW) field‐effect transistor (FET) biosensors are fabricated with a gold bowtie antenna. The transport and noise properties of these new NW FETs are investigated at 940 nm LED excitation in a 1 mm phosphate‐buffered saline (PBS) solution with pH = 7.4. A strong sensitivity of I–V and noise characteristics is revealed with an increase in LED intensity. Well‐resolved Lorentzian components are only found under the influence of light excitation. A two‐level RTS is successfully excited with linear dependence of its amplitude versus intensity. In addition, repeatable fluctuations in current are resolved as small peaks in I–V curves under infrared illumination, thus confirming the excitation of a two‐level RTS in the biosensors. The results demonstrate that the FET devices with a gold antenna have significant potential for the excitation of two‐level signals to enhance the sensitivity of biosensors.
Expanding the β‐Lactamase Family in the Human Microbiome
Authors: Jia Baolei , Baek Ju Hye , Lee Jae Kyeong , Sun Ying , Kim Kyung Hyun , Jung Ji Young , Jeon Che Ok 
Published: October 2024

Abstractβ‐lactams, the most common antibiotics globally, have resistance primarily determined by β‐lactamases. Human microbiota and β‐lactams influence mutually; however, β‐lactamase variety and abundance in the human microbiome remain partially understood. This study aimed to elucidate the diversity, abundance, and substrate spectrum of β‐lactamases. 1369 characterized β‐lactamases and 16 204 putative sequences are collected from protein databases. Upon clustering analysis and biochemical assays, nine proteins exhibiting less than 35% identity to those previously characterized are confirmed as β‐lactamases. These newly identified β‐lactamases originated from eight distinct clusters comprising 1163 β‐lactamases. Quantifying healthy participants (n = 2394) across 19 countries using functionally confirmed clusters revealed that Japan have the highest gut β‐lactamase abundance (log2[reads per million (RPM)] = 6.52) and Fiji have the lowest (log2[RPM] = 2.31). The β‐lactamase abundance is correlated with β‐lactam consumption (R = 0.50, p = 0.029) and income (R = 0.51, p = 0.024). Comparing individuals with ailments with healthy participants, β‐lactamase abundance in the gut is increased significantly in patients with colorectal cancer, cardiovascular diseases, breast cancer, and epilepsy. These outcomes provide insights into investigating antibiotic resistance, antibiotic stewardship, and gut microbiome‐antibiotic interactions.
Membrane Associated RNA‐Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice
Authors: Zhou Zhongqiu , Bai Ying , Gu Xiaochun , Ren Hui , Xi Wen , Wang Yu , Bian Liang , Liu Xue , Shen Ling , Xiang Xianyuan , Huang Wenhui , Luo Zhuojuan , Han Bing , Yao Honghong 
Published: October 2024

AbstractAstrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision‐tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. Microdomain calcium (Ca2+) transients in astrocytic processes are pivotal for the functional regulation of these processes. However, the understanding of the alterations and regulatory mechanism of microdomain Ca2+ transients during stroke remains limited. In the present study, a fast high‐resolution, miniaturized two‐photon microscopy is used to show that the levels of astrocytic microdomain Ca2+ transients are significantly reduced in the peri‐infarct area of awake ischemic stroke mice. This finding correlated with the behavioral deficits shown by these mice under freely‐moving conditions. Mitochondrial Ca2+ activity is an important factor driving the microdomain Ca2+ transients. DEAD Box 1 (DDX1) bound to circSCMH1 (a circular RNA involved in vascular post‐stroke repair) facilitates the formation of membrane‐associated RNA‐containing vesicles (MARVs) and enhances the activity of astrocytic microdomain Ca2+ transients, thereby promoting behavioral recovery. These results show that targeting astrocytic microdomain Ca2+ transients is a potential therapeutic approach in stroke intervention.
Safety Landscape of Therapeutic Nanozymes and Future Research Directions
Authors: Tagaras Nikolaos , Song Haihan , Sahar Shafaq , Tong Weijun , Mao Zhengwei , Buerki‐Thurnherr Tina 
Published: October 2024

AbstractOxidative stress and inflammation are at the root of a multitude of diseases. Treatment of these conditions is often necessary but current standard therapies to fight excessive reactive oxygen species (ROS) and inflammation are often ineffective or complicated by substantial safety concerns. Nanozymes are emerging nanomaterials with intrinsic enzyme‐like properties that hold great promise for effective cancer treatment, bacterial elimination, and anti‐inflammatory/anti‐oxidant therapy. While there is rapid progress in tailoring their catalytic activities as evidenced by the recent integration of single‐atom catalysts (SACs) to create next‐generation nanozymes with superior activity, selectivity, and stability, a better understanding and tuning of their safety profile is imperative for successful clinical translation. This review outlines the current applied safety assessment approaches and provides a comprehensive summary of the safety knowledge of therapeutic nanozymes. Overall, nanozymes so far show good in vitro and in vivo biocompatibility despite considerable differences in their composition and enzymatic activities. However, current safety investigations mostly cover a limited set of basic toxicological endpoints, which do not allow for a thorough and deep assessment. Ultimately, remaining research gaps that should be carefully addressed in future studies are highlighted, to optimize the safety profile of therapeutic nanozymes early in their pre‐clinical development.
Entropy Engineering of 2D Materials
Authors: Mei Hao , Zhang Yuxuan , Zhang Panpan , Ricciardulli Antonio Gaetano , Samorì Paolo , Yang Sheng 
Published: October 2024

AbstractEntropy, a measure of disorder or uncertainty in the thermodynamics system, has been widely used to confer desirable functions to alloys and ceramics. The incorporation of three or more principal elements into a single sublattice increases the entropy to medium and high levels, imparting these materials a mélange of advanced mechanical and catalytic properties. In particular, when scaling down the dimensionality of crystals from bulk to the 2D space, the interplay between entropy stabilization and quantum confinement offers enticing opportunities for exploring new fundamental science and applications, since the structural ordering, phase stability, and local electronic states of these distorted 2D materials get significantly reshaped. During the last few years, the large family of high‐entropy 2D materials is rapidly expanding to host MXenes, hydrotalcites, chalcogenides, metal‐organic frameworks (MOFs), and many other uncharted members. Here, the recent advances in this dynamic field are reviewed, elucidating the influence of entropy on the fundamental properties and underlying elementary mechanisms of 2D materials. In particular, their structure‐property relationships resulting from theoretical predictions and experimental findings are discussed. Furthermore, an outlook on the key challenges and opportunities of such an emerging field of 2D materials is also provided.
RNA‐seq analysis of mitochondria‐related genes regulated by AMPK in the human trophoblast cell line BeWo
Authors: Wu Bin , Gao Albert , He Bin , Chen Yun , Kong Xiangfeng , Wen Fayuan , Gao Haijun 
Published: October 2024

AbstractBackgroundHow AMP activated protein kinase (AMPK) signaling regulates mitochondrial functions and mitophagy in human trophoblast cells remains unclear. This study was designed to investigate potential players mediating the regulation of AMPK on mitochondrial functions and mitophagy by next generation RNA‐seq.MethodsWe compared ATP production in protein kinase AMP‐activated catalytic subunit alpha 1/2 (PRKAA1/2) knockdown (AKD) and control BeWo cells using the Seahorse real‐time ATP rate test, then analyzed gene expression profiling by RNA‐seq. Differentially expressed genes (DEG) were examined by Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Then protein–protein interactions (PPI) among mitochondria related genes were further analyzed using Metascape and Ingenuity Pathway Analysis (IPA) software.ResultsBoth mitochondrial and glycolytic ATP production in AKD cells were lower than in the control BeWo cells (CT), with a greater reduction of mitochondrial ATP production. A total of 1092 DEGs were identified, with 405 upregulated and 687 downregulated. GO analysis identified 60 genes associated with the term ‘mitochondrion’ in the cellular component domain. PPI analysis identified three clusters of mitochondria related genes, including aldo‐keto reductase family 1 member B10 and B15 (AKR1B10, AKR1B15), alanyl‐tRNA synthetase 1 (AARS1), mitochondrial ribosomal protein S6 (MRPS6), mitochondrial calcium uniporter dominant negative subunit beta (MCUB) and dihydrolipoamide branched chain transacylase E2 (DBT).ConclusionsIn summary, this study identified multiple mitochondria related genes regulated by AMPK in BeWo cells, and among them, three clusters of genes may potentially contribute to altered mitochondrial functions in response to reduced AMPK signaling.