bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal evaluation of cognitive deficits in patients with first episode of psychosis
Authors: Dardagani A. , Athanasis P. , Lagoudis A. , Ramnalis A. , Ntouros E. , Bozikas V. 
Published: June 2017

It has been well documented in many studies till now that patients in their first episode of psychosis demonstrate cognitive deficits. However, it is yet to be made clear how these deficits progress. Deterioration, stability or even amelioration in some domains has been noted from researchers. The aim of this study was to examine the longitudinal course of cognitive deficits over time. We administered a comprehensive battery of neuropsychological test to a group of first psychotic episode patients at the acute phase, 6 months and 1 year later. The sample comprised of 25 patients (13 male) in the first episode of psychosis. Specific tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) were used. The cognitive domains of attention, memory, working memory, visuospatial ability and planning, mental flexibility/shifting were examined. Repeated measures ANOVA was used in order to detect changes in the patients’ performance over time. According to our data, there was an improvement from baseline to 6 months in attention, planning and visual working memory. There was no change in performance in these cognitive domains from 6 months to 1 year from baseline. Memory, mental flexibility/shifting and visuospatial memory remained stable over time. Our data suggest variability concerning neuropsychological performance in specific tests examining different domains. Evaluation of cognitive function in the first episode of psychosis needs more thorough and comprehensive research, in relation to its course over time.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Effects of chronic antipsychotic treatment on neurophysiological correlates of the auditory oddball task in schizophrenia: A preliminary report from a multicentre study
Authors: Di Lorenzo G. , Mucci A. , Vignapiano A. , Giordano G. , Ferrentino F. , Niolu C. , Altamura M. , Marasco D. , Galderisi S. 
Published: June 2017

IntroductionThe effects of chronic antipsychotic administration on the human brain are debated. In particular, first-generation (FGAs) and second-generation antipsychotics (SGAs) seem to have different impacts on brain function and structure in subjects with schizophrenia. Few studies have investigated the effect of chronic administration of FGAs and SGAs on indices of brain function, such as event-related potentials (ERP) or neuropsychological performance.ObjectivesWithin the Italian Network for Research on Psychoses study, subjects stabilized on FGAs or SGAs were compared on P300, an ERP component, thought to reflect attention, working memory and context integration and on neurocognitive indices.MethodsERPs were recorded in 110 chronic, stabilized patients with Schizophrenia (28 used FGAs) during a standard auditory oddball task. P300 latency and amplitude were assessed at Pz channel. MATRICS Consensus Cognitive Battery (MCCB) was used for cognitive assessment.ResultsCompared with the SGAs group, patients on FGAs showed significant increased P300 latency (P = 0.003; Cohen's d = 0.67) and significant decreased P300 amplitudes (P = 0.023; Cohen's d = 0.38). The two groups did not differ on psychopathology and MCCB scores. Multiple linear regressions revealed that “FGAs vs. SGAs” (β = 0.298, P = 0.002) and MCCB neurocognitive composite T-score (β = –0.273, P = 0.004) were independent predictors of P300 latency, whereas only age (β = –0.220, P = 0.027) was an independent predictor of P300 amplitude.ConclusionsFGAs seem to affect the functional brain activity more than SGAs, particularly slowing cortical processing. Our results suggest that discrepant findings concerning P300 latency in schizophrenia might be related to the type of antipsychotic treatment used. Longitudinal studies are needed to further address this issue.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Diagnostic stability in the first episode of psychosis
Authors: Duarte M. , Batista A. , Maia J. 
Published: June 2017

IntroductionEarly intervention programs in psychosis have demonstrated efficiency in reduction the duration of untreated psychosis, relapse prevention, socio-professional integration and prognosis improvement. In daily practice, it is evident the clinical heterogeneity of the first episodes of psychosis (FEP), as well as the difficulty in initially assigning a specific diagnosis, being difficult to do the differential diagnosis and verifying, during follow-up, very different clinical outcomes among patients.Objectives/aimsTwo years after the start of specific consultation for FEP, the authors intended to characterize the followed patients and their evolution, comparing socio-demographic and clinical parameters, with emphasis on diagnosis at the first visit and after two years assessing their variability/stability.MethodsData research from a 48 patients sample followed up on the FEP consultation.ResultsThe diagnostics on the first consultation were 79% psychosis with no other specification (NOS), followed by cannabinoids addiction in 35%. After two years, in 29% of cases, there was a diagnostic change being actually 46% Psychosis NOS, 21% cannabinoids addiction and 17% schizophrenia. Initially, only 39% did not have previous history of toxic substances use, being 75% the current percentage. Six percent abandoned the consultation.ConclusionsThe authors conclude that, in this specific psychiatry consultation, it is important to initially keep an unspecified diagnostic, with further progressive evaluation allowing a more accurate diagnostic, since the initial diagnostic specification is often found to be incorrect, with adverse consequences for the patient. It would be useful to compare the results with a sample of patients under “as usual” treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Antidepressants and Driving Ability
Authors: Ramaekers J. 
Published: June 2017

Depression is a mental disorder that is likely to affect daily functions, including driving ability. However, driving performance of depressed patients remains poorly investigated. We will present 2 studies designed to assess driving performance of patients receiving long-term antidepressant treatment. The first study compared driving performance of untreated depressed patients, depressed patients receiving SSRI or SNRI treatment for 6–52 weeks and matched healthy controls. The second study compared driving performance of long-term users of sedative antidepressants to that of matched healthy controls. A standardized on-the-road driving test was used to assess standard deviation of lateral position (SDLP), a measure of weaving. In the first study, mean SDLP of untreated and treated patients were significantly higher as compared to SDLP of matched controls. Driving impairment in the treated group was significantly less as compared to the untreated group. SDLP was positively correlated to severity of depression across both groups of patients. In the second study, SDLP of patients receiving sedative antidepressants (e.g. mirtazapine) during 0,5–3 yrs was significantly higher as compared to matched controls. Driving performance of patients receiving sedative antidepressants for more than 3 yrs did not differ from matched controls. Severity of depression in these patients groups was low. It is concluded that symptoms of depression are a major cause of driving impairment. Reductions in severity of depression through antidepressant treatment reduce severity of driving impairment. Sedative antidepressants such as mirtazapine however can still induce driving impairment in patients with remission for up to 3 yrs of use.Disclosure of interestThe work presented was funded by the Dutch ministry of Infrastructure and transport and the European Committee.
The Prevalence and Correlates of Depression Awareness in Patients with Alcohol use Disorder
Authors: Charnsil C. , Aroonrattanapong R. 
Published: June 2017

IntroductionAlcoholic use disorder is a big problem in every country. It is the leading factor causing high disability-adjusted life year (DALYs). The National Institute of Mental Health Epidemiology Cathchment Area found that 37% of people with alcoholic use disorder had comorbid along with psychiatric disorder especially depression. In order to successfully treat patients with alcoholic use disorder, we have to treat their comorbidity along as well.AimTo examine the prevalence and correlation of depression awareness in patients with alcoholic use disorder.MethodsInpatients and outpatients who were diagnosed with alcoholic use disorder and alcohol dependence were invited to participate in this research. Subjects who had any history of depressive disorder treatment before were excluded. The awareness of depression was determined by the Illness Perception Questionnaire-Revised, IPQ-R. Depressive disorder was determined by the Thai version of the nine-item Patient Health Questionnaire (PHQ-9).ResultsNinety subjects with alcoholic use disorder agreed to join this research. Twenty-nine of the 90 (32.2%) had depression due to the PHQ-9 scale. Twenty-three were aware that they had depression and that was related to alcohol use. Using the logistic regression analysis, there were no significant factors related to this awareness.ConclusionThere is high prevalence of depression in patients with alcoholic use disorder and most of them have awareness did not receive treatment for depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Recovery Orientation as a Key Element in Addiction Treatment: Preliminary Results of a Patient's Survey
Authors: Eikmeier G. , von Heugel R. , Lacroix A. , Molkentin I. , Rosenbrock T. , Böttcher R. , Paul A. , Nachtigall J. 
Published: June 2017

“Recovery” in addiction treatment goes far beyond abstinence, but means a self-determined and meaningful life. Although this approach has been implemented in a number of programs, only little research has been carried out on this issue. Within the context of focusing our treatment program for addictive disorders more strongly according to recovery principles, we studied the baseline situation with the Bremerhavener Questionnaire of Treatment Satisfaction (BFPZ). Sixteen items cover different aspects of our traditional qualified inpatient detoxification program as well as recovery principles. Each item can be rated from 0 (strongly disagree) to 3 (strongly agree). Between December 1st 2015 and March 31st 2016, all in house patients with a substance abuse treated for more than 24 hours in the psychiatric department of Klinikum Bremerhaven Reinkenheide were asked to fill in the questionnaire (n = 201). Response rate was 35% (n = 70). Overall treatment satisfaction was high (mean: 2,57 ± 0.65). On the single item level, aspects of empathy and openness were rated best (mean > 2.3), while special aspects of personal recovery (choice, hope, life goals, diversity of treatment options) were rated worst (mean < 2.3). Eighty-nine percent of the patients wanted to stop their alcohol consumption completely, 2% wanted to break their consumption temporarily and 9% wanted to consume less. Thirty-four percent were interested in additional therapy offers for controlled substance use. The results will be presented in detail and discussed with regard to the implications for recovery-oriented addiction treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Cannabis-induced Psychotic Disorders and THC use Among Patients with Psychotic Symptoms
Authors: Fernandez-Quintana A. , Quiroga-Fernandez C. , Novo-Ponte A. , Garcia-Mahia M.D.C. 
Published: June 2017

IntroductionCausality between THC and psychotic symptoms has been outlined in several studies and a potential role for THC in the development of Schizophrenia remains to be assessed.MethodsRetrospective study undertaken in a sample of 124 patients assessed in an Emergency Department (ED) due to psychotic symptoms. Medical records were reviewed to obtain clinical and sociodemographic variables.Objectives(1) To analyse the prevalence of THC consumption among psychotic patients in ED; (2) to establish the prevalence of cannabis-induced psychotic disorder; (3) to underpin the socio-demographic and clinical variables associated with cannabis-induced psychosis.ResultsPersonal history of cannabis use 31.5% (6.5% as a single drug.) Accumulated time interval of cannabis use prior to the first psychotic episode: 0 – 5 years 15% (3.9% developed psychosis during the first year of cannabis use), 5 – 10 years 9.2%, more than 10 years 20.8%. Cannabis-induced psychotic disorder (F12.5) was diagnosed in 3.3% of the sample. The prevalence of this diagnosis was the same among male and female patients. The highest prevalence of cannabis-induced psychosis was found among 36–50 years old patients (50%). All patients with a diagnosis of Cannabis-induced psychotic disorder had a personal history of THC use and urine tests had been positive for THC in 75% of the cases. Habitat: 75% urban, 25% rural. Marital status: 50% single, 50% married.ConclusionsCannabis use is highly prevalent among patients who present with psychotic symptoms in ED and THC is correlated with psychotic episodes. The prevalence of cannabis-induced psychosis has also increased. Further studies comprising larger samples are warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The Impact of Psychopedagogical Intervention on Quality of Life in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) Treated with Psychostimulant Medication
Authors: Lima C. , Rodrigues D. , Silva M. , Rego S. 
Published: June 2017

Several studies have shown that ADHD has a significant negative impact on multiple domains of quality of life of children and adolescents, particularly in terms of behavioral, emotional and psychosocial quality of life. The psychopedagogical intervention can be therapeutic, preventive and promote educational inclusion. Moreover, it aims to address the learning process, how it is developed and how the individual relates himself to learning, both in the cognitive, social and emotional domains. Our purpose was to understand whether the psychopedagogical intervention influences the quality of life of adolescents with ADHD considering their pharmacological plans. The aim of this study was to evaluate the impact of a psychopedagogical intervention on quality of life of a sample of adolescents with ADHD taking into account their pharmacological plans (rubifen, ritalin, and concerta). We used quantitative and qualitative assessment measures: the KIDSCREEN-10, to measure the quality of life of these adolescents, and a semi-structured interview to assess the impact of a psychopedagogical intervention in the lives of these adolescents and their parents, respectively. The results showed that psychopedagogical intervention has a positive impact on the quality of life of adolescents with ADHD, as well as in the family dynamics. Due to the demands of school work (homework) and their negative impact on the family dynamics and consequently in the quality of life, the results corroborate the relevance of a psychopedagogical intervention to improve these areas. Thus, it appears that this type of intervention is very useful for adolescents with ADHD.Disclosure of interestThe authors have not supplied their declaration of competing interest.
High Bdi-21 Scores in Adolescents Without Depression are Associated with Negative Self-image, Immature and Neurotic Defense Styles and Adverse Life Events
Authors: Savilahti E.M. , Haravuori H. , Rytilä-Manninen M. , Lindberg N. , Marttunen M. 
Published: June 2017

IntroductionStructured self-reports, such as Beck's Depression Inventory (BDI) are widely used in assessing adolescents’ psychological wellbeing.ObjectivesTo investigate what factors are associated with discrepancies between BDI scores and diagnostic assessment in adolescent psychiatric patients and general population.AimsTo recognize what factors may contribute to high BDI scores besides depressive symptoms.MethodsThe study population consisted of 206 adolescents (13–17 years old) who were hospitalised for the first time in adolescent psychiatry and 203 age and gender matched adolescents recruited from schools in the same region. Study subjects filled self-reports on depression symptoms (BDI-21), substance misuse (AUDIT), psychiatric symptoms (SCL-90), defense styles (DSQ-40) and self-image (OSIQ). Diagnostics was based on K-SADS-PL interview, and/or clinical interview and clinical records when available. Information on background and life events was gathered from study subjects.ResultsWe compared subjects who scored in BDI-21 either 0–15 points or 16–63 points firstly among subjects who did not fill diagnostic criteria for current unipolar depression and secondly among those who did fulfill the diagnostic criteria. High BDI-21 scores in subjects without depression diagnosis were associated with female sex, older age, several adverse life events, higher psychiatric co-morbidity, worse self-image and more immature, neurotic and image-distorting defense styles (and less mature defense style). Low BDI-21 scores among subjects with depression diagnosis were associated with male sex, more positive self-image and less immature defense style.ConclusionsHigh BDI-21 scores may reflect a broad range of challenges in an adolescent's psychological development even in the absence of depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Mothers Mental Health of Children with Attention Deficit/Hyperactivity Disorder (ADHD)
Authors: Sepehrmanesh Z. 
Published: June 2017

BackgroundAttention deficit hyperactivity disorder (ADHD) is the most common neuropsychiatric disorder in pediatric populations with an early onset. Mental health of mother can effect on child mental health and relation between mother and child is very important. The aim of this study was investigation about mental health of mothers with children suffering from attention deficit/hyperactivity disorder.Materials and methodsThis cross sectional study was carried out on 100 mothers of children with ADHD diagnosis (Kashan, Iran). The data collection instruments included the Goldberg's General Health Questionnaire, and the questionnaire form includes the personal information and the variables associated to mental health.ResultsThe total means score of GHQ in the mothers’ was 26/6 ± 11/78. Fifty-eight percent of the mothers have mental health problem. The highest mean score in the sub scales was related to the anxiety subscale (7.73) and the most common mental health problem in these mothers was anxiety problems (11%). Mental health problem is most common in mothers with low socio-economic status, younger age than 30 years old, education lower than diploma degree, householder mothers, single, having boy child with ADHD, having child more than 9 years old.ConclusionAccording to the results of this study, 58% of the mothers have mental health problem. So with screening and on time diagnosis and treatment, we can prevent disadvantage effects of these problems on social and mental health of their children.Disclosure of interestThe author has not supplied his/her declaration of competing interest.
Factors Associated with Depression Severity in Adolescence
Authors: Serra G. , Casini M.P. , Maggiore V. , Baldessarini R.J. , Vicari S. 
Published: June 2017

IntroductionSevere depression is greatly impairing during adolescence and involves a high risk for suicidal behaviors.Objectives and aimsIdentify clinical and demographic factors associated with severity of depression in adolescents diagnosed with a major mood disorder so as to improve clinical treatment and prevent suicidal behaviors.MethodsWe analyzed factors associated with depression severity in 145 severely ill adolescents diagnosed with a major affective disorder using the K-SADS (Kiddie-Schedule for Affective Disorders and Schizophrenia) at the Mood Disorder Outpatient Program of Bambino Gesù Children's Hospital (Rome). Depressive and manic symptoms were rated with the CDRS-R (Children's Depression Rating Scale-Revised) and K-SADS-MRS (Mania Rating Scale), respectively. Bivariate comparisons were followed by multivariable linear regression modeling.ResultsDepression severity was greater among females than males (mean CDRS scores: 53.0 vs. 42.8; P < 0.0001) and with major depressive versus bipolar disorder diagnosis (50.4 vs. 45.4; P = 0.001). Manic symptoms, including irritability, mood lability, crowded thoughts, delusions, and insomnia, were more likely with more severe depression; their number and severity correlated with CDRS-R total score (respectively, β = 1.53 and 5.44;both P < 0.0001). Factors independently and significantly associated with CDRS-R depression score in multivariate modeling were:– presence of suicidal ideation;– absence of ADHD;– female sex;– greater number of manic symptoms.ConclusionsSevere depression was associated with manic symptoms and with suicidal ideation among adolescents diagnosed with either bipolar or major depressive disorders. This relationship should be considered in treatment planning and suicide prevention, including consideration of mood-stabilizing and antimanic agents in the treatment of severe adolescent depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
ICD-11 Psychotic Disorders: Preliminary Results of the Case-controlled Studies and the Russian Opinion
Authors: Kulygina M. , Krasnov V. , Ponisovskiy P. , Keeley J. , Reed G. 
Published: June 2017

IntroductionOne of the WHO's innovations for improving the ICD-11 chapter Mental and Behavioral Disorders was the creation of the Global Clinical Practice Network (GCPN), an international network of more than 12,000 mental health and primary care professionals from 144 countries.Aims and objectivesIn order to evaluate perceived clinical utility of the ICD-11 guidelines, the case-controlled field studies that involved the application of the proposed diagnostic guidelines to standardized case material were implemented via the Internet in different languages.MethodTwo hundred and seventy-eight Russian mental health care professionals, the GCPN members, have participated in case controlled Internet study for the chapter “Schizophrenia and Other Primary Psychotic Disorders”. Russian participants were represented by psychiatrists mostly (89%) and much less by psychologists (8%) which corresponds with the general situation in the Russian mental health care system.ResultsRussian clinicians have used the proposed ICD-11 diagnostic guidelines successfully to assess delusional disorder as well as schizophrenia. But there were certain categories (schizoaffective disorder, subthreshold delusions) with which the participants seemed to struggle. The critical comments were focused on opposing so called syndrome-based assessment and nosological diagnostics. Most concerns were about elimination of Schizophrenia subtypes.ConclusionRussian mental health care professionals proved to be interested in ICD revision process and demonstrated their special diagnostics opinion based on rich clinical traditions and psychopathological approach. In order to use ICD-11 guidelines in clinical practice more efficiently supplementary appropriate training would be needed.Disclosure of interestThe authors have not supplied their declaration of competing interest.