bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amplitude dependence of equivalent modal parameters in monitored buildings during earthquake swarms
Authors: Ceravolo Rosario , Matta Emiliano , Quattrone Antonino , Zanotti Fragonara Luca 
Published: May 2017

SummaryThis paper investigates the dynamic response of three sample buildings belonging to the Seismic Observatory for Structures, the Italian network for the permanent seismic monitoring of strategic structures, managed by the Italian Department of Civil Protection. The case studies cover different building types that could loosely represent the Italian building stock, with a special emphasis on cultural heritage and masonry structures.Observed under a low‐intensity seismic swarm comprising about 30 aftershocks after a main event, the three buildings are analysed through an input–output, model‐driven linear dynamic identification procedure, depicting the relation between the shaking level at the site and the variation of the equivalent structural modal parameters, while keeping into account the effects of soil–structure interaction. Finite element models will be used to investigate one of the case studies and to compare the law of variation of the structural modal parameters with respect to simplified models proposed by technical standards. Copyright © 2017 John Wiley & Sons, Ltd.
A simplified circular function–based gas kinetic scheme for simulation of incompressible flows
Authors: Yang L.M. , Shu C. , Yang W.M. , Wang Y. 
Published: May 2017

SummaryIn this paper, the circular function–based gas kinetic scheme (GKS), which is often applied for simulation of compressible flows, is simplified to improve computational efficiency for simulation of incompressible flows. In the original circular function–based GKS, the integral domain along the circle for computing conservative variables and numerical fluxes is usually not symmetric at the cell interface. This leads to relatively complicated formulations for computing the numerical flux at the cell interface. As shown in this work, for incompressible flows, the circle at the cell interface can be approximately considered to be symmetric. As a consequence, the simple expressions for calculation of conservative variables and numerical fluxes at the cell interface can be obtained, and computational efficiency is greatly improved. In the meanwhile, like the original circular function–based GKS, the discontinuity of conservative variables and their derivatives at the cell interface is still kept in the present scheme to keep good numerical stability at high Reynolds numbers. Several numerical examples, including decaying vortex flow, lid‐driven cavity flow, and flow past a stationary and rotating circular cylinder, are tested to validate the accuracy, efficiency, and stability of the present scheme.
An immersed boundary solver for inviscid compressible flows
Authors: Liu Cheng , Hu Changhong 
Published: May 2017

SummaryIn this paper, a simple and efficient immersed boundary (IB) method is developed for the numerical simulation of inviscid compressible Euler equations. We propose a method based on coordinate transformation to calculate the unknowns of ghost points. In the present study, the body‐grid intercept points are used to build a complete bilinear (2‐D)/trilinear (3‐D) interpolation. A third‐order weighted essentially nonoscillation scheme with a new reference smoothness indicator is proposed to improve the accuracy at the extrema and discontinuity region. The dynamic blocked structured adaptive mesh is used to enhance the computational efficiency. The parallel computation with loading balance is applied to save the computational cost for 3‐D problems. Numerical tests show that the present method has second‐order overall spatial accuracy. The double Mach reflection test indicates that the present IB method gives almost identical solution as that of the boundary‐fitted method. The accuracy of the solver is further validated by subsonic and transonic flow past NACA2012 airfoil. Finally, the present IB method with adaptive mesh is validated by simulation of transonic flow past 3‐D ONERA M6 Wing. Global agreement with experimental and other numerical results are obtained.
Baseline integrity property measurement of legacy oil and gas wells for carbon storage projects
Authors: Duguid Andrew , Butsch Robert , Carey J. William , Celia Michael , Chugunov Nikita , Gasda Sarah , Ramakrishnan T. S. , Stamp Vicki , Wang James 
Published: May 2017

AbstractAn import factor for long‐term storage is the integrity of wells penetrating the carbon storage reservoir. Well integrity will play a crucial role in establishing leakage risk in areas where there is a high density of existing (legacy) wells that could intersect operations including depleted petroleum fields where enhanced oil recovery or carbon storage will occur. The objective of this study was to develop methods that establish the baseline flow parameters from individual measurements in five wells in Wyoming. This paper describes the methods used to collect and analyze the data. The methods included isolation logging tools, in situ point and average permeability measurements, and laboratory tests on samples collected in the wells. The log results collected in the wells, considered in conjunction with the core measurements, indicate that interfaces and/or problems with cement placement related to eccentering provide preferential pathways for fluids, which increase the effective permeability of the barrier several orders of magnitude above that of intact cement. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd.
Altered sensorimotor cortical oscillations in individuals with multiple sclerosis suggests a faulty internal model
Authors: Arpin David J. , Heinrichs‐Graham Elizabeth , Gehringer James E. , Zabad Rana , Wilson Tony W. , Kurz Max J. 
Published: May 2017

AbstractMultiple sclerosis (MS) is a demyelinating disease that results in a broad array of symptoms, including impaired motor performance. How such demyelination of fibers affects the inherent neurophysiological activity in motor circuits, however, remains largely unknown. Potentially, the movement errors associated with MS may be due to imperfections in the internal model used to make predictions of the motor output that will meet the task demands. Prior magnetoencephalographic (MEG) and electroencephalographic brain imaging experiments have established that the beta (15‐30 Hz) oscillatory activity in the sensorimotor cortices is related to the control of movement. Specifically, it has been suggested that the strength of the post‐movement beta rebound may indicate the certainty of the internal model. In this study, we used MEG to evaluate the neural oscillatory activity in the sensorimotor cortices of individuals with MS and healthy individuals during a goal‐directed isometric knee force task. Our results showed no difference between the individuals with MS and healthy individuals in the beta activity during the planning and execution stages of movement. However, we did find that individuals with MS exhibited a weaker post‐movement beta rebound in the pre/postcentral gyri relative to healthy controls. Additionally, we found that the behavioral performance of individuals with MS was aberrant, and related to the strength of the post‐movement beta rebound. These results suggest that the internal model may be faulty in individuals with MS. Hum Brain Mapp 38:4009–4018, 2017. © 2017 Wiley Periodicals, Inc.
Profile and outcomes of women with pregnancy‐related acute kidney injury requiring dialysis at a center in Ethiopia
Authors: Bekele Delayehu , Ahmed Momina , Ibrahim Ahmed , Kedir Seman , Chan Grace 
Published: May 2017

AbstractObjectiveTo describe the clinical profile and outcomes of women with pregnancy‐related acute kidney injury (AKI) undergoing dialysis at Saint Paul's Hospital Millennium Medical College, Addis Ababa, where the first publicly funded large‐scale dialysis service in Ethiopia was established.MethodsIn a hospital‐based retrospective study, clinical records were reviewed for all women with pregnancy‐related AKI attending the hemodialysis unit at the study center between August 2013 and July 2015.ResultsIn total, 42 pregnant women with pregnancy‐related AKI underwent dialysis. Their mean age was 28.9 ± 5.9 years. The most common cause of pregnancy‐related AKI was pre‐eclampsia or eclampsia (31/42, 74%), followed by puerperal sepsis (6/42, 14%). The mean number of dialysis sessions was 4.8 ± 4.6; the most common indication for dialysis was refractory fluid overload (35/42, 83%). Overall, 35 (83%) women were discharged with improvement, 5 (12%) died, and 2 (5%) absconded. Of the five maternal deaths, three women had pre‐eclampsia‐related AKI and two had puerperal sepsis‐related AKI.ConclusionHypertensive disorders of pregnancy were the leading cause of pregnancy‐related AKI, which can be easily prevented with early diagnosis and timely intervention. Improving the quality of prenatal care to recognize hypertensive disorders during pregnancy, coupled with prompt management, might help to reduce maternal morbidity and mortality related to AKI.
Admitted or Denied: Multilingual Writers Negotiate Admissions Essays
Authors: Wight Shauna 
Published: May 2017

AbstractThis article presents data from a collection of yearlong case studies on resident multilingual writers’ college admissions essays. The focal student in this piece revealed the challenges that such writers face in presenting themselves to college admissions officers. Exploring these cultural and linguistic conflicts, this analysis uses Goffman's performance theories, which argue that writers (re)construct identities in response to changing social cues. Literacy educators, researchers, and policymakers can use these insights to help resident multilingual writers balance the demands of academic audiences with their preferred forms of representation.
Adhesive force between graphene nanoscale flakes and living biological cells
Authors: Al Faouri Radwan , Henry Ralph , Biris Alexandru S. , Sleezer Rob , Salamo Gregory J. 
Published: May 2017

AbstractWe report on a measurement technique that quantifies the adhesive force between multi‐layers of graphene flakes and the cell wall of live Escherichia coli cells using atomic force microscopy (AFM) in‐fluid Peak Force‐ Quantitative Nanomechanical Mapping mode. To measure the adhesive force, we made use of the negative charge of E. coli cells to allow them to stick to positively charged surfaces, such as glass or silicon, that were covered by poly‐L‐Lysine. With this approach, cells were held in place for AFM characterization. Both pristine graphene (PG) flakes and functionalized graphene (FG) flakes were put on the E. coli cells and measurements of lateral size, flake thickness, and adhesion were made. Using this approach, the measured values of the adhesive force between multi‐layers of graphene flakes (total thickness of 50 nm) and E. coli was determined to be equal or greater than 431 ± 65pN for (PG) and 694 ± 98pN for the (FG). More interestingly, the adhesive force of a graphene flake (thickness 1.3 nm) with the cell is determined to be equal or greater than 38.2 ± 16.4pN for the (PG) and 34.8 ± 15.3pN for the (FG). These interaction values can play an important role in determining and understanding the possible toxicity of graphene flakes. Copyright © 2017 John Wiley & Sons, Ltd.
Fluorescence hyperspectral imaging (fHSI) using a spectrally resolved detector array
Authors: Luthman Anna Siri , Dumitru Sebastian , Quiros‐Gonzalez Isabel , Joseph James , Bohndiek Sarah E 
Published: May 2017

AbstractThe ability to resolve multiple fluorescent emissions from different biological targets in video rate applications, such as endoscopy and intraoperative imaging, has traditionally been limited by the use of filter‐based imaging systems. Hyperspectral imaging (HSI) facilitates the detection of both spatial and spectral information in a single data acquisition, however, instrumentation for HSI is typically complex, bulky and expensive. We sought to overcome these limitations using a novel robust and low cost HSI camera based on a spectrally resolved detector array (SRDA). We integrated this HSI camera into a wide‐field reflectance‐based imaging system operating in the near‐infrared range to assess the suitability for in vivo imaging of exogenous fluorescent contrast agents. Using this fluorescence HSI (fHSI) system, we were able to accurately resolve the presence and concentration of at least 7 fluorescent dyes in solution. We also demonstrate high spectral unmixing precision, signal linearity with dye concentration and at depth in tissue mimicking phantoms, and delineate 4 fluorescent dyes in vivo. Our approach, including statistical background removal, could be directly generalised to broader spectral ranges, for example, to resolve tissue reflectance or autofluorescence and in future be tailored to video rate applications requiring snapshot HSI data acquisition.
Surface‐enhanced Raman scattering analysis of urine from deceased donors as a prognostic tool for kidney transplant outcome
Authors: Chi Jingmao , Ma Yiwei , Weng Francis L. , Thiessen‐Philbrook Heather , Parikh Chirag R. , Du Henry 
Published: May 2017

AbstractWe report the utility of surface‐enhanced Raman scattering (SERS) analysis of urine from deceased donors for prognosis of kidney transplant outcomes. Iodide‐modified silver nanoparticles were used as the enabler for sensitive measurements of urine proteins. Principal component analysis (PCA) and linear discriminant analysis (LDA) were employed for the statistical analysis of the SERS data. Thirty urine samples in three classes were analysed. The ATN class consists of donors whose kidneys had acute tubular necrosis (ATN), the most common type of acute kidney injury (AKI) with high risk of poor graft performance in recipients, yet yielded acceptable transplant outcome. The DGF class is comprised of donors whose kidney had delayed graft function (DGF) in recipients. The control class includes donors whose kidneys did not have donor ATN or recipient DGF. We show a sensitivity of more than 90 % in differentiating the ATN class from the DGF and control classes. Our methodology can thus help clinicians choose kidneys in the high‐risk ATN category for transplant which would otherwise be discarded. Our research is impactful in that it could serve as a valuable guidance to expand the deceased donor pool to include those perceived as high‐risk AKI type based on common urinary biomarkers. Picutre: Scheme of SERS analysis of urine samples from deceased donors for kidney transplant outcome indication.
Robust numerical phase stabilization for long‐range swept‐source optical coherence tomography
Authors: Song Shaozhen , Xu Jingjiang , Men Shaojie , Shen Tueng T. , Wang Ruikang K. 
Published: May 2017

AbstractA novel phase stabilization technique is demonstrated with significant improvement in the phase stability of a micro‐electromechanical (MEMS) vertical cavity surface‐emitting laser (VCSEL) based swept‐source optical coherence tomography (SS‐OCT) system. Without any requirements of hardware modifications, the new fully numerical phase stabilization technique features high tolerance to acquisition jitter, and significantly reduced budget in computational effort. We demonstrate that when measured with biological tissue, this technique enables a phase sensitivity of 89 mrad in highly scattering tissue, with image ranging distance of up to 12.5 mm at A‐line scan rate of 100.3 kHz. We further compare the performances delivered by the phase‐stabilization approach with conventional numerical approach for accuracy and computational efficiency. Imaging result of complex signal‐based optical coherence tomography angiography (OCTA) and Doppler OCTA indicate that the proposed phase stabilization technique is robust, and efficient in improving the image contrast‐to‐noise ratio and extending OCTA depth range. The proposed technique can be universally applied to improve phase‐stability in generic SS‐OCT with different scale of scan rates without a need for special treatment.
Plasmonic nanoparticles‐decorated diatomite biosilica: extending the horizon of on‐chip chromatography and label‐free biosensing
Authors: Kong Xianming , Li Erwen , Squire Kenny , Liu Ye , Wu Bo , Cheng Li‐Jing , Wang Alan X. 
Published: May 2017

AbstractDiatomite consists of fossilized remains of ancient diatoms and is a type of naturally abundant photonic crystal biosilica with multiple unique physical and chemical functionalities. In this paper, we explored the fluidic properties of diatomite as the matrix for on‐chip chromatography and, simultaneously, the photonic crystal effects to enhance the plasmonic resonances of metallic nanoparticles for surface‐enhanced Raman scattering (SERS) biosensing. The plasmonic nanoparticle‐decorated diatomite biosilica provides a lab‐on‐a‐chip capability to separate and detect small molecules from mixture samples with ultra‐high detection sensitivity down to 1 ppm. We demonstrate the significant potential for biomedical applications by screening toxins in real biofluid, achieving simultaneous label‐free biosensing of phenethylamine and miR21cDNA in human plasma with unprecedented sensitivity and specificity. To the best of our knowledge, this is the first time demonstration to detect target molecules from real biofluids by on‐chip chromatography‐SERS techniques.
Membrane therapeutic plasma exchange with and without heparin anticoagulation
Authors: Brunetta Gavranić Bruna , Bašić‐Jukić Nikolina , Premužić Vedran , Kes Petar 
Published: May 2017

AbstractBackgroundAdministration of an anticoagulant during therapeutic plasma exchange (TPE) is necessary to avoid circuit clotting and impaired treatment effectiveness. Citrate is the preferred anticoagulant for apheresis worldwide, and unfractionated heparin (UH) is the second most preferred, yet there are only a few published studies regarding the use of UH during TPE. There are even fewer studies regarding the use of low‐molecular‐weight heparin (LMWH) and TPE performed without anticoagulation.Materials and MethodsWe retrospectively analyzed the database of the Department of Nephrology at Zagreb University Hospital Center from 1982 to 2014 to test the safety of various heparin anticoagulation in TPE. We grouped procedures according to anticoagulation type (UH, LMWH, and no anticoagulation) and compared differences in the use of anticoagulants during our study period, patient populations, replacement fluids, and complications.ResultsComplications were recorded during 11.1% of the 9,501 procedures. The incidence of any recorded complication was significantly higher in the LMWH group (21.2%) compared to the group with no anticoagulation (16.3%) and the UH group (9.5%) (P < 0.001). Similarly, the blood clotting in the extracorporeal circuit was most common in the LMWH group (LMWH, 12.0%; no anticoagulation, 6.3%; UH, 2.4%; P < 0.001). Incidents of bleeding complications were very low and occurred during or after 13 TPE sessions (0.1% of all procedures).ConclusionsOur findings indicate that TPE procedures can be conducted safely with UH and, when necessary, without anticoagulation. The use of LMWH was associated with more complications when compared with use of UH and to TPE done without anticoagulation. Further studies are necessary to study its use during TPE procedures.
Inhibition of Endoplasmic Reticulum Stress Apoptosis by Estrogen Protects Human Umbilical Vein Endothelial Cells Through the PI3 Kinase–Akt Signaling Pathway
Authors: Su Qing , Wang Yu , Yang Xin , Li Xiao‐Dong , Qi Yong‐Fen , He Xiao‐Jing , Wang Yan‐Jie 
Published: May 2017

ABSTRACTWe aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, and the ERS signaling pathways were examined in human umbilical vein endothelial cells (HUVECs) and measured using Western blot, Hoechst stains and caspase‐3 activity assay. In vitro, 10−8 mol/l estrogen directly inhibited the up‐regulation of the ERS marker glucose‐regulated protein 78 (GRP78) and ERS apoptosis marker C/EBP homologous protein (CHOP). ERS was induced using the ERS inducer tunicamycin (TM, 10 µmol/l) or dithiothreitol (DTT, 2 mmol/l) in HUVECs. Estrogen can also decrease the apoptosis cells mediated by ERS, based on the results of Hoechst stains. Protein expression in the three main ERS signaling pathways was upregulated in TM‐ or DTT‐induced HUVEC ERS. Increases in p‐PERK/PERK were the most obvious, and estrogen significantly inhibited the upregulation of p‐PERK/PERK, p‐IRE1/IRE1, and ATF6. These inhibitory effects were abolished by specific estrogen receptor antagonists (ICI182, 780, and G15) and inhibitors of the E2 post‐receptor signaling pathway, including phosphoinositide 3‐kinase (PI3K) inhibitor LY294002, p38‐mitogen activated protein kinase (p38‐MAPK) inhibitor SB203580, c‐Jun N‐terminal kinase (JNK) inhibitor SP600125 and extracellular signal‐regulated kinases1/2 (ERK1/2) inhibitor U0126; of these inhibitors, LY294002 was the most effective. Further experiments showed that when the PI3K pathway was blocked, the inhibitory effect of estrogen on ERS apoptosis was reduced. Estrogen can prevent HUVEC apoptosis by inhibiting the ERS apoptosis triggered by the PERK pathway, which may protect vascular endothelial cells and the cardiovascular system. The main mechanism responsible for ERS inhibition is the activation of the PI3K‐Akt pathway for the activated estrogen receptor. J. Cell. Biochem. 118: 4568–4574, 2017. © 2017 Wiley Periodicals, Inc.
Andrographolide Induces Cell Cycle Arrest and Apoptosis of Chondrosarcoma by Targeting TCF‐1/SOX9 Axis
Authors: Zhang Huan‐Tian , Yang Jie , Liang Gui‐Hong , Gao Xue‐Juan , Sang Yuan , Gui Tao , Liang Zu‐Jian , Tam Man‐Seng , Zha Zhen‐Gang 
Published: May 2017

ABSTRACTChondrosarcoma is the second most malignant bone tumor with poor prognosis and limited treatment options. Thus, development of more effective treatments has become urgent. Recently, natural compounds derived from medicinal plants have emerged as promising therapeutic options via targeting multiple key cellular molecules. Andrographolide (Andro) is such a compound, which has previously been shown to induce cell cycle arrest and apoptosis in several human cancers. However, the molecular mechanism through which Andro exerts its anti‐cancer effect on chondrosarcoma remains to be elucidated. In the present study, we showed that Andro‐induced G2/M cell cycle arrest of chondrosarcoma by fine‐tuning the expressions of several cell cycle regulators such as p21, p27, and Cyclins, and that prolonged treatment of cells with Andro caused pronounced cell apoptosis. Remarkably, we found that SOX9 was highly expressed in poor‐differentiated chondrosarcoma, and that knockdown of SOX9 suppressed chondrosarcoma cell growth. Further, our results showed that Andro dose‐dependently down‐regulated SOX9 expression in chondrosarcoma cells. Concomitantly, an inhibition of T cell factor 1 (TCF‐1) mRNA expression and an enhancement of TCF‐1 protein degradation by Andro were observed. In contrast, the expression and subcellular localization of β‐catenin were not altered upon the treatment of Andro, suggesting that β‐catenin might not function as the primary target of Andro. Additionally, we provided evidence that there was a mutual regulation between TCF‐1 and SOX9 in chondrosarcoma cells. In conclusion, these results highlight the potential therapeutic effects of Andro in treatment of chondrosarcoma via targeting the TCF‐1/SOX9 axis. J. Cell. Biochem. 118: 4575–4586, 2017. © 2017 Wiley Periodicals, Inc.