bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Product Distribution Strategy in Digital Publishing Industry Based on Game-Theory
Authors: Xu Li-ping , Chen Haiyan 
Published: April 2017

Abstract
The digital publishing output increased significantly year by year. It has been the most vigorous point of economic growth and has been more important to press and publication industry. Its distribution channel has been diversified, which is different from the traditional industry. A deep research has been done in digital publishing industry, for making clear of the constitution of the industry chain and establishing the model of industry chain. The cooperative and competitive relationship between different distribution channels have been analyzed basing on a game-theory. By comparing the distribution quantity and the market size between the static distribution strategy and dynamic distribution strategy, we get the theory evidence about how to choose the distribution strategy to get the optimal benefit.
Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival
Authors: Humar Mojca , Kern Izidor , Vlacic Gregor , Hadzic Vedran , Cufer Tanja 
Published: April 2017

Abstract

Background
The insulin-like growth factor 1 receptor (IGF1R) expression has been addressed as a potential prognostic marker in non-small-cell lung cancer (NSCLC) in various studies; however, the associations between IGF1R expression and prognosis of advanced NSCLC patients is still controversial. The aim of our observational, cohort study was to evaluate the expression of IGF1R in advanced NSCLC and its prognostic role. A subgroup analysis was performed to address the influence of pre-existing type 2 diabetes mellitus (T2DM) status on IGF1R expression and overall survival (OS).

Patients and methods
IGF1R expression was evaluated in 167 consecutive advanced NSCLC patients (stage IIIB and IV), diagnosed and treated at one university institution, between 2005 and 2010. All patients received at least one line of standard cytotoxic therapy and 18 of them had pre-existing T2DM. IGF1R expression was determined by immunohistochemical (IHC) staining, with score ≥ 1+ considered as positive. Information on baseline characteristics, as well as patients’ follow-up data, were obtained from the hospital registry. Associations of IGF1R expression with clinical characteristics and overall survival were compared.

Results
IGF1R expression was positive in 79.6% of patients, significantly more often in squamous-cell carcinoma (SCC) compared to non-squamous-cell (NSCC) histology (88.7% vs. 74.3%; P = 0.03). IGF1R positivity did not correlate with T2DM status or with other clinical features (sex, smoking status, performance status). Median OS was similar between IGF1R positive and IGF1R negative group (10.2 vs. 8.5 months, P = 0.168) and between patients with or without T2DM (8.7 vs. 9.8 months, P = 0.575). Neither IGF1R expression nor T2DM were significant predictors of OS.

Conclusions
IGF1R or T2DM status were not significantly prognostic in described above collective of advanced NSCLC treated with at least one line of chemotherapy. In addition, no association between T2DM status and IGF1R expression was found. Further studies on IGF1R expression and its prognostic as well as therapeutic consequences in a larger collective of advanced NSCLC patients, with or without T2DM, are needed.
New bioactive compounds from the marine-derived actinomycete Nocardiopsis lucentensis sp. ASMR2
Authors: Eliwa Essam M. , Abdel-Razek Ahmed S. , Frese Marcel , Wibberg Daniel , Halawa Ahmed H. , El-Agrody Ahmed M. , Bedair Ahmed H. , Kalinowski Jörn , Sewald Norbert , Shaaban Mohamed 
Published: April 2017

Abstract
In the search for new bioactive compounds from extremophilic actinomycetes, a new marine actinomycete strain, Nocardiopsis lucentensis sp. ASMR2 has been isolated and taxonomically identified from marine plants collected in the Red Sea at Hurghada coasts. A large-scale fermentation of the strain on modified rice solid medium was performed, followed by work-up and purification of the obtained extract using a series of chromatographic purifications, delivering the novel butenolide system 3′-hydroxy-N-(2-oxo-2,5-dihydrofuran-4-yl)propionamide (1a) along with the naturally new 4-methoxy-2H-isoquinolin-1-one (2). Furthermore, eight known bioactive compounds are also reported, namely, indole-3-carboxylic acid, indole-3-acetic acid, indole-3-acetic acid methyl ester, furan-2,5-dimethanol, tyrosol, glycerol linoleate, cyclo-(Tyr, Pro), and adenosine. The chemical structures of the new compounds (1a, 2) were confirmed by extensive one- and two-dimensional (1D and 2D) nuclear magnetic resonance (NMR) spectroscopy, electron ionization high resolution (EI-HR) mass spectrometry, and by comparison with literature data. The antimicrobial activity of the strain extract, as well as of compounds 1a and 2, were studied using a panel of pathogenic microorganisms. The in vitro cytotoxicity of the bacterial extract and compounds 1a and 2 were studied against the human cervix carcinoma cell line (KB-3-1) and its multidrug-resistant subclone (KB-V1).
Age-Related Reversals in Neural Recruitment across Memory Retrieval Phases
Authors: Ford Jaclyn H. , Kensinger Elizabeth A. 
Published: April 2017

Over the last several decades, neuroimaging research has identified age-related neural changes that occur during cognitive tasks. These changes are used to help researchers identify functional changes that contribute to age-related impairments in cognitive performance. One commonly reported example of such a change is an age-related decrease in the recruitment of posterior sensory regions coupled with an increased recruitment of prefrontal regions across multiple cognitive tasks. This shift is often described as a compensatory recruitment of prefrontal regions due to age-related sensory-processing deficits in posterior regions. However, age is not only associated with spatial shifts in recruitment, but also with temporal shifts, in which younger and older adults recruit the same neural region at different points in a task trial. The current study examines the possible contribution of temporal modifications in the often-reported posterior–anterior shift. Participants, ages 19–85, took part in a memory retrieval task with a protracted retrieval trial consisting of an initial memory search phase and a subsequent detail elaboration phase. Age-related neural patterns during search replicated prior reports of age-related decreases in posterior recruitment and increases in prefrontal recruitment. However, during the later elaboration phase, the same posterior regions were associated with age-related increases in activation. Further, ROI and functional connectivity results suggest that these posterior regions function similarly during search and elaboration. These results suggest that the often-reported posterior–anterior shift may not reflect the inability of older adults to engage in sensory processing, but rather a change in when they recruit this processing.SIGNIFICANCE STATEMENTThe current study provides evidence that the often-reported posterior–anterior shift in aging may not reflect a global sensory-processing deficit, as has often been reported, but rather a temporal modification in this processing in which older adults engage the same neural regions during a detail elaboration phase that younger adults engage during memory search. In other words, older adults may ultimately be able to engage the same processes as younger adults during some cognitive tasks when given the time to do so. Future research should examine the generalizability of this effect and the importance of encouraging older adults to engage in these processes through task instruction or questions.
O riso discreto e o soneto cômico: A uns olhos tortos
Authors: Da Silva Cássio Roberto Borges , De Novais Valeria Pereira Silva 
Published: April 2017

Este ensaio versa sobre a codificação dos argumentos risíveis nas práticas discursivas da Sociedade Corte. Os tratados de cortesia e as poéticas do Antigo Regime, apropriando-se da noção aristotélica de cômico, definem a matéria risível como torpeza física ou moral. De acordo com tais textos, o emprego de ditos risíveis deveria atender a um decoro áulico, codificado, basicamente, em função de duas finalidades: por um lado, a recreação dos ânimos, por outro, a ordenação agradável dos modos. Identificamos, pois, um gradativo deslocamento na normativa ética e poética, centrada, inicialmente, em questões relativas à matéria do riso e, posteriormente, nos dispositivos elocutivos que poderiam ser empregados em seu tratamento, ou seja, se, inicialmente, os preceptores definem o dito gracioso como amplificação de deformidades aparentes, posteriormente, a codificação do riso discreto concentra-se no tratamento engenhoso de torpezas propriamente ditas. O soneto cômico A uns olhos tortos, atribuído a Bacelar, exemplifica tais usos.********************************************************************The discreet laughter and the comic sonnet: The crossed eyesAbstract: His essay deals with the coding of laughable arguments in the discursive practices of the Court Society. The treaties of courtesy and the poetic of the Old Regime, appropriating the Aristotelian notion of comic, define laughable matter as a physical or moral turpitude. According to these texts, the use of laughable sayings should serve to an aulic decorum, coded, mainly because of two purposes: on the one hand as the recreation of spirits and on the other hand as pleasant sort of manners. We identify a gradual shift in the ethical and poetic norm, focusing initially on issues related to the matter of laughter and subsequently in elocutive devices that could be used in its treatment, that is, if initially the tutors define the graceful saying as an amplification of apparent deformities, later on, the codification of discreet laughter focuses on ingenious treatment of shame itself. The comic sonnet The crossed eyes, attributed to Bacelar, exemplifies such use.Keywords: laughter; decorum; engenius.
Estudio de los vínculos entre cultura organizacional y calidad de los servicios educativos en la imagen institucional de una universidad privada confesional
Authors: Turpo Chaparro Josué , Jaimes Donald 
Published: April 2017

<p>La calidad de los servicios académicos, junto con la imagen institucional y la cultura organizacional son factores clave en el proceso de licenciamiento universitario. El objetivo de este artículo es determinar la relación que tiene la calidad de los servicios académicos y la cultura organizacional en la imagen institucional de una institución privada confesional. La metodología utilizada es correlacional bajo el enfoque cuantitativo. Se trata de una correlación múltiple con propósito de causalidad que pretende explicar las relaciones existentes, a través del análisis de regresión lineal múltiple ANOVA. Se aplicaron tres instrumentos, el Organizational Culture Survey (DOCS) de Denison de 60 ítems; el Instrumento de evaluación escala de Satisfacción Estudiantil en cuanto a la Calidad Educativa (SEICE) 93 ítems y el cuestionario de Imagen Institucional para públicos selectos de Escobar de 31 ítems. Los instrumentos de cultura y calidad utilizaron como evaluación la escala tipo Likert de cinco puntos, en el caso del instrumento de imagen se calificó a través signos positivos y negativos. Los instrumentos fueron aplicados a una población de 221 personas del público alumnos de una universidad privada confesional. Entre los resultados se obtuvieron relaciones significativas entre las variables estudiadas y sus dimensiones. Se concluye que la valoración positiva de la imagen institucional se ve afectada por la cultura organizacional y la calidad de los servicios educativos. </p>
HEAVY RAINFALL AND TEMPERATURE PROYECTIONS IN A CLIMATE CHANGE SCENARIO OVER QUITO, ECUADOR
Authors: Serrano Vincenti Sheila , Ruiz Jean Carlos , Bersosa Fabián 
Published: April 2017

<p>Esta investigación analiza eventos extremos a nivel diario de temperaturas mínimas, máximas y lluvias en el Distrito Metropolitano de Quito utilizando datos con más de 30 años de la red meteorológica del INAMHI (Instituto Nacional de Meteorología e Hidrología de Ecuador), y utilizando el programa R-ClimDex. Se presentan escenarios el año 2032 combinando resultados estadísticos de eventos extremos con el forzamiento físico de los escenarios A2 y B2 del modelo de cambio climático PRECIS A2 y B2, y utilizando la teoría de valores extremos del programa extReme. Los resultados mostraron un incremento en los valores mensuales mínimos y máximos de temperatura tanto en magnitud y frecuencia; además de un aumento en la intensidad de lluvias extremas. Las proyecciones para 2032 mantienen este comportamiento, con resultados que deben ser tomados en cuenta por los tomadores de decisión y científicos debido al peligro que significan para el ecosistema de Quito. </p>
EFECTO DE LA SUPLEMENTACIÓN CON LEVADURA DE CERVEZA (Saccharomyces cerevisiae) Y PROMOTORES EN LA GESTACIÓN Y RECRÍA DE CUYES (Cavia porcellus)
Authors: Castro Muñoz Eloy , Narváez Jiménez Pablo Xavier , Ortega Ojeda Carlos Alberto 
Published: April 2017

<p>En Tumbaco, Pichincha a 2460 m.s.n.m., se evaluó el efecto de la suplementación alimenticia con sistemas nutricionales constituidos por la combinación de: levadura de cerveza (Saccharomyces cerevisiae), Indumix (mezcla mineral y vitamínica) y A-V 25 (complejo vitamínico con antibiótico) durante las etapas de gestación y recría de cuyes (Cavia porcellus). Se utilizó un diseño completamente al azar, el número de tratamientos fueron ocho, durante la etapa de gestación se utilizaron de cuatro a cinco animales por tratamiento y durante la etapa de recría se utilizaron cuatro animales machos y cuatro animales hembra por tratamiento que fueron seleccionados al azar. Las Variables analizadas fueron: incremento de peso, incremento de longitud, conversión alimenticia, consumo de balanceado, consumo de forraje, mortalidad, peso de los gazapos al nacer y análisis financiero. Durante la etapa de gestación no se presentó significancia estadística en incrementos de peso; durante la etapa de recría en gazapos machos, el tratamiento que alcanzó mayor incremento de peso y longitud fue t7 (Testigo + Levadura de cerveza + Indumix + A-V 25) con 821 g/cuy y 11,92 cm/cuy respectivamente; para el caso de gazapos hembras, el mejor tratamiento fue t7 (Testigo + Levadura de cerveza + Indumix + A-V 25) con incremento de peso de 816,5 g/cuy y un incremento de longitud de 11,80 cm/cuy . Finalmente la mejor Relación Beneficio/Costo tuvo el tratamiento t7 (Testigo + Levadura de cerveza + Indumix + A-V 25) y t6 (Testigo + Indumix + A-V 25) con un valor de 1,13 USD,B/C.</p><p> </p><p> </p><p><strong><br /></strong></p>
DETERMINACIÓN DE LOS VALORES DE REFERENCIA EN EL HEMOGRAMA DE CABALLOS NACIDOS O CRIADOS A MÁS DE 3000 M.S.N.M. EN LA SIERRA CENTRO NORTE ECUATORIANA
Authors: Izurieta Barzola José Luis , Luna Diego , Cedeño Prócel Yolanda Mercedes , Chacha Vega Sergio Rolando 
Published: April 2017

<p>En la sierra centro norte ecuatoriana se realizó un estudio de hemograma a 100 caballos mayores de dos años de edad, criados sobre los 3000 m.s.n.m., el objetivo de esta investigación fue determinar valores hematológicos a esta altitud y compararlos con otros estudios realizados a nivel del mar. Las muestras sanguíneas fueron tomadas en reposo de los animales y enviadas al laboratorio para ser analizadas en el equipo de hematología automática Mindray R BC2800Vet, para el análisis de los datos y determinar los valores de referencia se utilizó el complemento de Microsoft Excel R Reference Value Advisor. Las muestras fueron tomadas de caballos criollos ecuatorianos para obtener datos hematológicos de este tipo de caballos antes no estudiado. Se encontraron 82 muestras idóneas para establecer valores de hemograma con distribución normal, glóbulos rojos 6,23 − 10,84 × 106/mL; hemoglobina 11,4−18,4 g/L; hematocrito 32,3−52,3%; volumen corpuscular medio 40,2−57 fL; hemoglobina corpuscular media 14−20,3 pg; concentración de hemoglobina corpuscular media 32−37 g/L; glóbulos blancos 4,8−12×103/mL; linfocitos 1,4 − 7,5 × 103/mL; monocitos 0,2 − 0,7 × 103/mL; granulocitos 2,2 − 8,8 × 103/mL; linfocitos% 16,8 − 64,9%, monocitos% 2,9−7%, granulocitos% 30,5−78,7%; plaquetas 101−401×103/mL . Los resultados se compararon con referencias bibliográficas internacionales y se encontró diferencias significativas (P&lt; 0,05) en glóbulos rojos, hemoglobina, hematocrito y monocitos en el estudio de Böhmwald et al., (1984); diferencia significativa en hematocrito, volumen corpuscular medio, linfocitos, monocitos y plaquetas con el estudio de Giordano et al., (2008); mientras que con el estudio de Díaz et al., (2011) hubo diferencia significativa con la hemoglobina, monocitos y plaquetas.</p><p> </p>
Investigation of Heavy Metal Levels in Drinking-and Well- Water Samples Using ICP-MS Method
Authors: MEHDIZADEHTAPEH LEILA , TEKİNER İSMAİL HAKKI , OZPINAR HAYDAR 
Published: April 2017

Heavy metals have potentially detrimental impacts on the whole body or on certain organs. They may induce various sorts of severe disorders, including neuro-, nephro-, carcino-, terato-, and immunological. Humans are exposed to them by breathing, eating, and drinking. Especially, the water sources from which drinking water is derived can represent a route of transmission of heavy metals to the humans. Therefore, waterborne heavy metals even at trace level have become a concern all across the world, including Turkey. The objective of this study was to investigate the elemental concentrations of nine major heavy metals (B, Cr, Ni, Cu, As, Cd, Sb, Hg and Pb) in 125 water samples (25 samples of each of plastic-bottled, glass-bottled, natural mineral, tap and well water) from Istanbul, Turkey using ICP-MS method. Sample preparation and analytical procedure were conducted according to the methods of EPA-3005A and EPA-6020A. Descriptive statistics and associations between the elemental levels in the sampling groups were evaluated by one-way ANOVA using SPSS-19 statistical package programme (P-value<0.05). Our study demonstrated that analyses showed a large range in concentration for most of the elements. Overall, 91.2% of all the waters analyzed fell within the Guideline values recommended by the Ministry of Health in Turkey. However, 8.8% of the samples (7 natural mineral water, 2 tap water, 2 bottled-water and 1 well water) for B, and 0.8% of the samples (1 well water) for Ni were above the safe limits. Based on the order of elemental concentrations, plastic-bottled waters had B > Cu > As > Ni > Pb > Cr > Sb > Cd, glass-bottled waters had B > As > Cu > Ni > Cr > Sb > Pb > Cd, natural mineral waters had B > Cu > As > Ni > Cr > Sb > Hg > Pb > Cd, tap waters had B > Cu > As > Ni > Cr > Pb > Sb > Hg > Cd, and well waters had B > Cu > Ni > As > Cr > Pb > Hg > Sb > Cd. Statistically, there was a positive and significant correlation existing between Ni, Cd, Sb and Pb in the waters, which indicated towards their common source of origin. In conclusion, our study indicated that there was low-to-moderate heavy metal contamination in all the drinking- and well- water samples. There is no a severe health risk for the consumers living in Istanbul because Turkey does not have no other population large enough like Istanbul in which to study high exposures of heavy metals through the waters for human consumption and use.
A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women
Authors: Kalita Neelakkhi , Choudhury Biju Dutta 
Published: April 2017

Background: To determine serum calcium, serum magnesium, and BMI (body mass index) in premenopausal and postmenopausal women, and find out any changes in these after menopause, and the independent association of serum calcium, serum magnesium with BMI in pre and post-menopausal women , if any.Methods: 100 adult women attending Gauhati medical college outdoor clinics were included in the study. Patients with medical history of major systemic diseases, women on hormone replacement therapy, and women who had surgical menopause were not included in the study. Estimation of serum calcium and serum magnesium from cubital venous blood was done by photocolorimetry method. For statistical analysis the value of laboratory parameters were presented as the Mean±SD (standard deviation). A Student’s unpaired t-test was used for cross-sectional comparisons of continuous variables between the groups.Results: The mean serum calcium and also the mean serum magnesium levels were lower in the postmenopausal group and was statistically significant. Though the mean BMI in the postmenopausal group was higher than the premenopausal group, it was found to be statistically not significant.Conclusions: The postmenopausal subjects had lower mean values of serum calcium and serum magnesium, but within the normal serum reference values.
Clinico-radiological profile of abdominal tuberculosis in HIV/AIDS patients-a study from rural central India
Authors: Wafai Nisar A. , Yadav Sudhir K. , Singh Prem S. , Kumar Manoj , Singh Prafulla K. , Sharma Himanshu , Pious Tony , Gautam Rajesh K. 
Published: April 2017

Background: One of the major challenge of present era is dual epidemic of HIV/AIDS and tuberculosis. With immunosuppression, risk of opportunistic diseases increases in these patients and tuberculosis is most common opportunistic infection. The prevalence of abdominal tuberculosis seems to be rising, particularly due to increasing prevalence of HIV infection. The diagnosis of abdominal tuberculosis can often be difficult and it remains underdiagnosed, in view of its nonspecific manifestations. The investigations involved in its diagnosis are expensive and time consuming, however, ultrasonography (USG) is an affordable, non-invasive and widely available modality which can be of help in the diagnosis of abdominal tuberculosis. Therefore, this study was undertaken to evaluate clinical and USG finding among Abdominal Tuberculosis patients with HIV/AIDS.Methods: After informed consent, patients underwent thorough history taking and clinical examination followed by high quality USG abdomen and other biochemical and haematological tests including CD4 count. Follow up USG abdomen was done at time of completion of course of ATT and data was analysed.Results: 45 were found to have abdominal tuberculosis. Of these patients, 31(68.9%) were male and 14 (31.1%) were female. Mean age of HIV-abdominal TB was 34.27±9.66 years. most common symptoms were weight loss 41(91.1%), loss of appetite 38(84.4%), fever 32(71.1%), generalized weakness 30(66.7%) and abdominal pain 27(60.0%). On USG abdomen, intraabdominal lymphadenopathy was most common finding found in 44(97.8%). Average size of enlarged lymph node was 3.1+-1.0 cm. Mesenteric lymphnodes were enlarge in 40(88.89%), paraaortic 8(17.78%), retroperitoneal 4(8.89%) while peripancreatic and porta hepatic in 3(6.67%). splenomegaly was noted in 14(31.1%) cases. Hepatomegaly was found in 6 cases, who all were male. Ascites was evident in 5(11.1%) patients. Extensive involvement, defined as involvement of two or more intraabdominal sites, was found 24(53.3%) cases. There was no statistically significant difference found among these USG findings and CD4 count.Conclusions: The findings of lymphadenopathy (size>15mm) and hypoechoic/necrotic echotexture, hepatosplenomegaly with hypoechoic lesions in ultrasonography are suggestive of abdominal tuberculosis in HIV infected patients with unexplained nonspecific symptoms and low CD4 count. However, above findings are not standardized and inability to confirm the diagnosis of tuberculosis by direct microscopy and culture is the limitation of this study. Ultrasonography is an affordable, widely available, non-invasive imaging modality which may be optimally utilized for the diagnosis of abdominal tuberculosis in HIV infected patients, especially in the rural setup where microbiological and other sophisticated radiological investigations have limited availability.