bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of colorectal cancer follow-up after potentially curative resection
Authors: Mokhles S , Macbeth F , Farewell V , Fiorentino F , Williams N R , Younes R N , Takkenberg J J M , Treasure T 
Published: August 2016

Abstract

Background
After potentially curative resection of primary colorectal cancer, patients may be monitored by measurement of carcinoembryonic antigen and/or CT to detect asymptomatic metastatic disease earlier.

Methods
A systematic review and meta-analysis was conducted to find evidence for the clinical effectiveness of monitoring in advancing the diagnosis of recurrence and its effect on survival. MEDLINE (Ovid), Embase, the Cochrane Library, Web of Science and other databases were searched for randomized comparisons of increased intensity monitoring compared with a contemporary standard policy after resection of primary colorectal cancer.

Results
There were 16 randomized comparisons, 11 with published survival data. More intensive monitoring advanced the diagnosis of recurrence by a median of 10 (i.q.r. 5–24) months. In ten of 11 studies the authors reported no demonstrable difference in overall survival. Seven RCTs, published from 1995 to 2016, randomly assigned 3325 patients to a monitoring protocol made more intensive by introducing new methods or increasing the frequency of existing follow-up protocols versus less invasive monitoring. No detectable difference in overall survival was associated with more intensive monitoring protocols (hazard ratio 0·98, 95 per cent c.i. 0·87 to 1·11).

Conclusion
Based on pooled data from randomized trials published from 1995 to 2016, the anticipated survival benefit from surgical treatment resulting from earlier detection of metastases has not been achieved.
ChemInform Abstract: Prediction and Synthesis of a Non‐Zintl Silicon Clathrate.
Authors: Cerqueira Tiago F. T. , Pailhes Stephane , Debord Regis , Giordano Valentina M. , Viennois Romain , Shi Jingming , Botti Silvana , Marques Miguel A. L. 
Published: August 2016

AbstractHigh‐throughput DFT calculations are used to predict the thermodynamic stability of ternary type I Si clathrates.
ChemInform Abstract: Poling‐Written Ferroelectricity in Bulk Multiferroic Double‐Perovskite BiFe0.5Mn0.5O3.
Authors: Delmonte Davide , Mezzadri Francesco , Gilioli Edmondo , Solzi Massimo , Calestani Gianluca , Bolzoni Fulvio , Cabassi Riccardo 
Published: August 2016

AbstractPolycrystalline BiFe0.5Mn0.5O3 is prepared by hot pressing of stoichiometric amounts of Bi2O3, Fe2O3, and Mn2O3 (Au capsule in multianvil cell, 6 GPa, 1100 °C, 1.5 h).
ChemInform Abstract: Structural, Magnetic, and Optical Properties of A3V4(PO4)6 (A: Mg, Mn, Fe, Co, Ni).
Authors: Porter Spencer H. , Xiong Jie , Avdeev Maxim , Merz David , Woodward Patrick M. , Huang Zhenguo 
Published: August 2016

AbstractThe title phosphates are prepared by solid state reaction of stoichiometric mixtures of M3(PO4)2 (M: Mg, Mn, Fe, Co, Ni) and VPO4 (evacuated quartz tubes, 1050 °C, 10 h).
ChemInform Abstract: Photochemical Route for Synthesizing Atomically Dispersed Palladium Catalysts.
Authors: Zheng Nanfeng , et al.  
Published: August 2016

AbstractStable atomically dispersed Pd catalyst particles on ethylene glycolate (EG)‐stabilized ultrathin TiO2 nanosheet supports (Pd ≤1.5%) are prepared by UV irradiation (Xe lamp) of an aqueous suspension of two‐atom‐thick TiO2 nanosheets and H2PdCl4.
ChemInform Abstract: Na0.5Ce0.5MoO4 as a New Light Absorption Material to Efficiently Degrade RhB under Visible Light Irradiation.
Authors: Yang Liming , Teng Fei , Xu Juan , Yang Yang , Kan Yandong , Gu Wenhao 
Published: August 2016

AbstractNa0.5Ce0.5MoO4 is prepared by hydrothermal reaction of Na2MoO4 and Ce(NO3)3 in the presence of excess (H2N)2CS (autoclave, 180 °C, 2 d).
ChemInform Abstract: Hydrodeoxygenation of Sulfoxides to Sulfides by a Pt and MoOx Co‐Loaded TiO2 Catalyst.
Authors: Touchy Abeda Sultana , Hakim Siddiki S. M. A. , Onodera Wataru , Kon Kenichi , Shimizu Ken‐ichi 
Published: August 2016

AbstractTitle catalyst is used for the dehydrogenation of sulfoxides to sulfides under solvent‐free and mild conditions.
ChemInform Abstract: Direct Reductive Amination of Aldehydes with Nitroarenes Using Bio‐Renewable Formic Acid as a Hydrogen Source.
Authors: Zhang Qi , Li Shu‐Shuang , Zhu Ming‐Ming , Liu Yong‐Mei , He He‐Yong , Cao Yong 
Published: August 2016

AbstractSecondary amines are directly synthesized through reductive amination of aldehydes with nitroarenes using formic acid as the reductant.
ChemInform Abstract: Highly Efficient Synthesis of Primary Amides via Aldoximes Rearrangement in Water under Air Atmosphere Catalyzed by an Ionic Ruthenium Pincer Complex.
Authors: Yang Fa‐Liu , Zhu Xinju , Rao Dun‐Kang , Cao Xiao‐Niu , Li Ke , Xu Yan , Hao Xin‐Qi , Song Mao‐Ping 
Published: August 2016

AbstractThe transformation of aldoximes to primary amides is achieved using a pincer ruthenium complex in water under air.
ChemInform Abstract: Catalyst‐Free Synthesis of Amines from Cyclic Ketones and Formamides in Superheated Water.
Authors: Kumar Macharla Arun , Srujana Kodumuri , Swamy Peraka , Naresh Mameda , Durgaiah Chevella , Rammurthy Banothu , Narender Nama 
Published: August 2016

AbstractAmines (II) and (IV) are simply and efficiently synthesized through an environmentally benign protocol from cyclic ketones and formamide or substituted formamides (III), resp., without any catalyst under superheated water conditions.
ChemInform Abstract: Stereoselective Synthesis of Dehydroamino Acids Using Malonic Acid Half Oxyester and Aromatic Aldehydes.
Authors: Singjunla Yuttapong , Colombano Silvia , Baudoux Jerome , Rouden Jacques 
Published: August 2016

AbstractThe title synthesis is applicable to aromatic, hetaromatic and alkenyl aldehydes and provides Z dehydroamino acids in moderate to high yields.
ChemInform Abstract: An Efficient and Green Method for Regio‐ and Chemo‐Selective Friedel—Crafts Acylations Using a Deep Eutectic Solvent ([CholineCl][ZnCl2]3).
Authors: Tran Phuong Hoang , Nguyen Hai Truong , Hansen Poul Erik , Le Thach Ngoc 
Published: August 2016

Abstract[CholineCl][ZnCl2]3 is used as a dual function catalyst and green solvent for the Friedel—Crafts acylation of aromatic compounds instead of using moisture‐sensitive Lewis acids and volatile organic solvents.
ChemInform Abstract: Phenyliodonium Diacetate Mediated Oxidative Functionalization of Styrenes with Molecular Oxygen: Synthesis of α‐Oxygenated Ketones.
Authors: Samanta Supravat , Donthiri Ramachandra Reddy , Ravi Chitrakar , Adimurthy Subbarayappa 
Published: August 2016

AbstractVariously substituted styrenes, 1H‐indene, 1,2‐dihydronaphthalene, and cyclohexa‐1,3‐diene readily react with N‐hydroxyphthalimide or N‐hydroxybenzotriazole in the presence of PhI(OAc)2 and molecular oxygen.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Enamides with Sterically Hindered α‐Bromocarbonyls
Authors: Ding Ran , Huang Zhi‐Dao , Liu Zheng‐Li , Wang Tian‐Xiang , Xu Yun‐He , Loh Teck‐Peng 
Published: August 2016

Abstractaffording various multi‐substituted alkene products under mild reaction conditions
ChemInform Abstract: Dual C—F, C—H Functionalization via Photocatalysis: Access to Multifluorinated Biaryls.
Authors: Senaweera Sameera , Weaver Jimmie D. 
Published: August 2016

AbstractThis photocatalytic coupling of one C—F bond of a polyfluoroarene with the C—H bond of another arene uses readily accessible starting materials, proceeds under mild conditions, and shows high functional group tolerance, thus offering a benign alternative to traditional cross‐coupling strategies.
ChemInform Abstract: Arylcalixarenyl Phosphines in Palladium‐Catalyzed Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Elaieb Fethi , Hedhli Ahmed , Semeril David , Matt Dominique 
Published: August 2016

AbstractCalix[4]arene (CAX) is an efficient ligand for Pd‐catalyzed Miyaura cross‐coupling reactions of sterically hindered aryl chlorides and boronic acids.
ChemInform Abstract: Ligand‐Promoted Rh(III)‐Catalyzed Coupling of Aryl C—H Bonds with Arylboron Reagents.
Authors: Wang Huai‐Wei , Cui Pei‐Pei , Lu Yi , Sun Wei‐Yin , Yu Jin‐Quan 
Published: August 2016

AbstractA regioselective Rh(III)‐catalyzed C—H arylation of arenes with arylboronic acid pinacol esters is developed using N‐pentafluorophenylbenzamide as directing group.
ChemInform Abstract: Preparation of 2‐Azetidinones by Cyclocondensation of Carboxylic Acids and Imines via Diphosphorustetraiodide.
Authors: Zarei Maaroof , Maaqooli Fatemeh 
Published: August 2016

AbstractTitle compounds are directly synthesized by reaction of imines (I) with carboxylic acids using diphosphorus tetraiodide under mild conditions.
ChemInform Abstract: Direct CuO Nanoparticle‐Catalyzed Synthesis of Poly‐Substituted Furans via Oxidative C—H/C—H Functionalization in Aqueous Medium.
Authors: Payra Soumen , Saha Arijit , Guchhait Sandip , Banerjee Subhash 
Published: August 2016

AbstractThe title furans are prepared by functionalization of 1,3‐dicarbonyls or β‐keto esters with α,β‐unsaturated carbonyl compounds via conjugate addition initiated domino reaction.
ChemInform Abstract: Cu(I)‐Catalyzed Synthesis of Furan‐Substituted Allenes by Use of Conjugated Ene‐Yne Ketones as Carbene Precursors.
Authors: Hu Fangdong , Xia Ying , Ma Chen , Zhang Yan , Wang Jianbo 
Published: August 2016

AbstractThe mild reaction protocol allows for the preparation of a wide range of furan substituted allenes which may contain various functional groups.
ChemInform Abstract: Diastereoselective Cascade Assembly of Functionalized Pyrano[3,4‐c]pyrrole Derivatives.
Authors: Ievlev Mikhail Yu. , Ershov Oleg V. , Tafeenko Viktor A. 
Published: August 2016

AbstractThe starting materials are readily obtained from acid‐catalyzed reaction of ketones with tetracyanoethylene.
ChemInform Abstract: Sequential Diels—Alder Reactions in a Conjugated Tetraene System.
Authors: Saeed Abaee M. , Mohammadi Mohadeseh , Mohammadi Akram , Mojtahedi Mohammad M. , Taghi Rezaei M. , Saberi Farveh , Harms Klaus 
Published: August 2016

AbstractReaction of dienone (I) with two equivalents of N‐phenylmaleimide proceeds as a sequence of two sequential Diels—Alder reactions furnishing the bis‐adduct (III) in excellent yield.
ChemInform Abstract: An Efficient and Recyclable Thiourea‐Supported Copper(I) Chloride Catalyst for Azide—Alkyne Cycloaddition Reactions.
Authors: Barman Milan Kr. , Sinha Ashish Kumar , Nembenna Sharanappa 
Published: August 2016

AbstractVarious triazole derivatives are synthesized via [3 + 2] cycloaddition reaction of azides with terminal alkynes (II) or alkyne (VI) using the title copper complex as a highly active catalyst.
ChemInform Abstract: KMnO4/AcOH‐Mediated C3‐Selective Direct Arylation of Coumarins with Arylboronic Acids.
Authors: Yuan Jin‐Wei , Yang Liang‐Ru , Yin Qiu‐Yue , Mao Pu , Qu Ling‐Bo 
Published: August 2016

AbstractThe KMnO4 alkylation and arylation of coumarins (I) with boronic acids proceeds regioselectively to afford 3‐substituted coumarin derivatives (III) and (V).
ChemInform Abstract: Silyl Assistance in the Intramolecular Addition of Pyridyl Radicals onto Pyridines and Quinolines.
Authors: Filace Fabiana , Sanchez‐Murcia Pedro A. , Sucunza David , Perez‐Redondo Adrian , Alvarez‐Builla Julio , Gago Federico , Burgos Carolina 
Published: August 2016

AbstractIntramolecular acylpyridine‐centered radical attack on azine nitrogen generates stable acylazinium salts.
ChemInform Abstract: Rhodium‐Catalyzed Selective Oxidative Coupling of 7‐Azaindoles.
Authors: Li Shuai‐Shuai , Wang Cheng‐Qi , Li Wei‐Huan , Zhang Xiao‐Mei , Dong Lin 
Published: August 2016

AbstractVarious 1‐aryl‐1H‐pyrrolo[2,3‐b]pyridines are selectively coupled with styrene, acrylic acid derivatives or vinyl ethyl ether in position 2 of the aryl substituent.
ChemInform Abstract: Time‐Efficient Synthesis of Pyrido[2,3‐d]pyrimidinones via α‐Oxoketenes.
Authors: Castillo Juan‐Carlos , Quiroga Jairo , Rodriguez Jean , Coquerel Yoann 
Published: August 2016

AbstractReactive α‐oxoketenes are generated in situ by a microwave‐assisted Wolff rearrangement of 2‐diazo‐1,3‐dicarbonyl educts.
ChemInform Abstract: Intramolecular Functionalization of Benzylic Methylene Adjacent to the Ring Nitrogen Atom in N‐Aryltetrahydroisoquinoline Derivatives.
Authors: Yang Liu , Zhang‐Negrerie Daisy , Zhao Kang , Du Yunfei 
Published: August 2016

AbstractThe intramolecular cross‐dehydrogenative cross‐coupling reaction offers access to tetracyclic tetrahydroisoquinoline derivatives with a newly formed C(sp3)—N, C(sp3)—O or C(sp3)—C bond.
ChemInform Abstract: Synthesis of Azepino[4,5‐b]indol‐4‐ones via MCR/Free Radical Cyclization and in vitro—in silico Studies as 5‐Ht6R Ligands.
Authors: Renteria‐Gomez Angel , Islas‐Jacome Alejandro , Diaz‐Cervantes Erik , Villasenor‐Granados Tayde , Robles Juvencio , Gamez‐Montano Rocio 
Published: August 2016

AbstractThis is the first report describing the formation of the title compounds (VII) in which the precursors (VI) are prepared in a one‐pot manner by a multicomponent reaction.
ChemInform Abstract: Access to Diverse Oxygen Heterocycles via Oxidative Rearrangement of Benzylic Tertiary Alcohols.
Authors: Kelley Brandon T. , Walters Jennifer C. , Wengryniuk Sarah E. 
Published: August 2016

AbstractSynthetically challenging seven‐membered ring acetals are prepared via a novel oxidative rearrangement of benzylic alcohols using poly(cationic) hypervalent iodine reagents for the first time.
ChemInform Abstract: Unsaturated Phosphonates as Hauser Acceptors for the Synthesis of Phosphonylated Dihydroxynaphthalenes and Naphthoquinones.
Authors: Chaturvedi Atul Kumar , Rastogi Namrata 
Published: August 2016

Abstract3‐Benzotriazolylphthalides react equally efficiently with either alkenyl or alkynylphosphonates to form 1,4‐dihydronaphthalines which may further be oxidized to the corresponding 2‐phosphonate substituted 1,4‐naphthoquinones equipped with various (het)aryl groups in position 3.
Assessment of the Pharmacokinetics, Pharmacodynamics, and Safety of Single Doses of TV‐1106, a Long‐Acting Growth Hormone, in Healthy Japanese and Caucasian Subjects
Authors: Cohen‐Barak Orit , Barkay Hadas , Rasamoelisolo Michele , Butler Kathleen , Yamada Kazumasa , Bassan Merav , Yoon Esther , Spiegelstein Ofer 
Published: August 2016

AbstractTV‐1106 is a human serum albumin genetically fused to recombinant human growth hormone, designed to provide a long‐acting alternative to daily growth hormone (GH) injections in patients with GH deficiency. This study investigated the pharmacokinetics, pharmacodynamics, and safety of single subcutaneous doses of TV‐1106 (7.5, 15, 50, and 100 mg) in Japanese (n = 44) and caucasian (n = 44) healthy subjects. TV‐1106 pharmacokinetics and pharmacodynamics were comparable in Japanese and caucasian populations. TV‐1106 demonstrated relatively slow absorption (median tmax, 10–30 hours) and a mean elimination half‐life of 26–36 hours. Apparent clearance and volume of distribution decreased with increasing TV‐1106 doses in both populations and appeared to increase more than dose proportionality across the tested doses. Insulin‐like growth factor‐1 (IGF‐1) and IGF binding protein‐3 (IGFBP‐3) increased in a dose‐related manner, with maximum responses observed at 33–96 and 42–109 hours, respectively. IGF‐1 and IGFBP‐3 returned to baseline values at 168 hours following 7.5 and 15 mg of TV‐1106, and 336 hours following 50 and 100 mg of TV‐1106. TV‐1106 appeared safe in both populations. There was no evidence of differences in pharmacokinetics, pharmacodynamics, or safety of TV‐1106 between Japanese and caucasian populations. The data also demonstrate long‐acting growth hormone properties of TV‐1106 and support its potential for once‐weekly dosing.
Long time horizon for adaptive management to reveal predation effects in a salmon fishery
Authors: Walsworth Timothy E. , Schindler Daniel E. 
Published: August 2016

AbstractPredator–prey interactions shape ecosystem structure and function, potentially limiting the productivity of valuable species. Simultaneously, stochastic environmental forcing affects species productivity, often through unknown mechanisms. The interacting effects of trophic and environmental conditions complicate management of exploited ecosystems and have motivated calls for more holistic management via ecosystem‐based approaches, yet the limitations to these approaches are not widely appreciated. The Chignik salmon fishery in Alaska is managed to achieve maximum sustainable yield for sockeye salmon, though research suggests that predation by less economically valuable, and thus not targeted, coho salmon during juvenile rearing limits the productivity of sockeye salmon. We examined the relationship between historical sockeye salmon recruitment and coho salmon abundance observed in the Chignik system and could not detect a clear effect of coho salmon abundance on sockeye salmon productivity, given existing data. Using simulation models, we examined the probability of detecting a known predation effect on sockeye salmon recruitment in the presence of observation error in coho salmon abundance and stochasticity in sockeye salmon recruitment. Increased recruitment stochasticity reduced the ability to detect predator effects in recruitment, an effect further strengthened when low frequency environmental variation was added to the system. Further, increased observation error biased estimates of predator effects towards zero. Thus, in systems with high observation error on predator abundances, estimates of predation effects will be substantially weaker than true effects. We examined the effects of stochasticity on the ability of an adaptive management program to learn about ecosystem structure and detect an effect of management actions intended to release a prey species from its predators. Simulation models revealed that even under scenarios of large predation effects on sockeye salmon, stochastic recruitment masked detection of an effect of increased coho salmon harvest for nearly a decade. These results highlight the challenges inherent in ecosystem‐based management of predator–prey systems due to mismatched timescales of ecosystem dynamics and the willingness of stakeholders to risk losses in order to test uncertain hypotheses. It is critical for stakeholders considering EBFM (ecosystem‐based fisheries management) and adaptive management strategies to be aware of the potential timelines of perceiving ecosystem change.
Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload
Authors: Pintalhao Mariana , Castro‐Chaves Paulo , Vasques‐Novoa Francisco , Gonçalves Francisco , Mendonça Luís , Fontes‐Carvalho Ricardo , Lourenço Patrícia , Almeida Pedro , Leite‐Moreira Adelino , Bettencourt Paulo 
Published: August 2016

AbstractAimsDespite the promising results of serelaxin as a new potential acute heart failure (HF) therapy, its clinical use preceded the understanding of the endogenous relaxin system in HF. We aimed to evaluate relaxin circulating levels in a population of acute HF and their association with clinical and echocardiographic parameters.Methods and resultsWe included 117 patients from a registry of acute HF. Admission serum relaxin was measured using an enzyme‐linked immunosorbent assay (ELISA) kit. Clinical, analytical, and echocardiographic parameters were compared between patients with relaxin levels above and below the median. Median age was 82 years [interquartile range (IQR) 72–87], 41% of the patients were male, and 63% had systolic dysfunction. Median serum relaxin was 31.4 pg/mL (IQR 0.6–89.8). Patients with relaxin levels above the median had more peripheral oedema (89.8% vs. 68.4%, P = 0.004) and a significantly higher sodium retention score (mean 4.8 ± 1.5 vs. 3.6 ± 2.0, P < 0.001). These patients also had significantly higher systolic pulmonary arterial pressure [median 47.0 (IQR 36.0–61.0) vs. 34.5 (IQR 25.0–51.0) mmHg, P = 0.002], higher prevalence of right ventricular (RV) systolic dysfunction (28.1% vs. 10.3%, P = 0.02), RV dilation (31.0% vs. 5.3%, P < 0.001), and right atrial dilation (66.1% vs. 36.5%, P = 0.002), and less inferior vena cava diameter variability (40% vs. 60%, P = 0.009). No differences were noted regarding admission blood pressure, left chamber dimensions, or LV function.ConclusionIn our population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
The effect of land cover change on duration and severity of high and low flows
Authors: Ahn Kuk‐Hyun , Merwade Venkatesh 
Published: August 2016

AbstractLand cover has been increasingly recognized as an important factor affecting hydrologic processes at the basin and regional level. Therefore, improved understanding of how land cover change affects hydrologic systems is needed for better management of water resources. The objective of this study is to investigate the effects of land cover change on the duration and severity of high and low flows by using the Soil Water Assessment Tool model, Bayesian model averaging and copulas. Two basins dominated by different land cover in the Ohio River basin are used as study area in this study. Two historic land covers from the 1950s and 1990s are considered as input to the Soil Water Assessment Tool model, thereby investigating the hydrologic high and low flow response of different land cover conditions of these two basins. The relationships between the duration and severity of both low and high flow are defined by applying the copula method; changes in the frequency of the duration and severity are investigated. The results show that land cover changes affect both the duration and severity of both high and low flows. An increase in forest area leads to a decrease in the duration and severity during both high and low flows, but its impact is highest during extreme flows. The results also show that the land cover changes have had significant influences on changes in the joint return periods of duration and severity of low and high flows. While this study sheds light on the role of land cover change on severity and duration of high and low flow conditions, more studies using various land cover conditions and climate types are required in order to draw more reliable conclusions in the future. Copyright © 2016 John Wiley & Sons, Ltd.
Floods in the Southern Alps of New Zealand: the importance of atmospheric rivers
Authors: Kingston Daniel. G. , Lavers David A. , Hannah David M. 
Published: August 2016

AbstractExtremely high precipitation occurs in the Southern Alps of New Zealand, associated with both orographic enhancement and synoptic‐scale weather processes. In this study, we test the hypothesis that atmospheric rivers (ARs) are a key driver of floods in the Southern Alps of New Zealand. Vertically integrated water vapour and horizontal water vapour transport, and atmospheric circulation, are investigated concurrently with major floods on the Waitaki River (a major South Island river). Analysis of the largest eight winter maximum floods between 1979 and 2012 indicates that all are associated with ARs. Geopotential height fields reveal that these ARs are located in slow eastward moving extratropical cyclones, with high pressure to the northeast of New Zealand. The confirmation of ARs as a contributor to Waitaki flooding indicates the need for their further exploration to better understand South Island hydrometeorological extremes. Copyright © 2016 John Wiley & Sons, Ltd.