bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity
Authors: Jansen Rick J. , Argos Maria , Tong Lin , Li Jiabei , Rakibuz-Zaman Muhammad , Islam Md. Tariqul , Slavkovich Vesna , Ahmed Alauddin , Navas-Acien Ana , Parvez Faruque , Chen Yu , Gamble Mary V. , Graziano Joseph H. , Pierce Brandon L. , Ahsan Habibul 
Published: December 2015

AbstractBackground: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%) varies across individuals, reflecting differences in arsenic metabolism capacity.Methods: The association of arsenic metabolism phenotypes with participant characteristics and arsenical skin lesions was characterized among 4,794 participants in the Health Effects of Arsenic Longitudinal Study (Araihazar, Bangladesh). Metabolism phenotypes include those obtained from principal component (PC) analysis of arsenic species.Results: Two independent PCs were identified: PC1 appears to represent capacity to produce DMA (second methylation step), and PC2 appears to represent capacity to convert iAs to MMA (first methylation step). PC1 was positively associated (P &lt;0.05) with age, female sex, and BMI, while negatively associated with smoking, arsenic exposure, education, and land ownership. PC2 was positively associated with age and education but negatively associated with female sex and BMI. PC2 was positively associated with skin lesion status, while PC1 was not. 10q24.32/AS3MT region polymorphisms were strongly associated with PC1, but not PC2. Patterns of association for most variables were similar for PC1 and DMA%, and for PC2 and MMA% with the exception of arsenic exposure and SNP associations.Conclusions: Two distinct arsenic metabolism phenotypes show unique associations with age, sex, BMI, 10q24.32 polymorphisms, and skin lesions.Impact: This work enhances our understanding of arsenic metabolism kinetics and toxicity risk profiles. Cancer Epidemiol Biomarkers Prev; 25(2); 381–90. ©2015 AACR.
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1–Related Hepatocellular Carcinoma
Authors: Huang Xiao-Ying , Yao Jin-Guang , Huang Bing-Chen , Ma Yun , Xia Qiang , Long Xi-Dai 
Published: December 2015

Abstract
Background: Altered expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is observed in hepatocellular carcinoma. The genetic polymorphisms of this gene in aflatoxin B1 (AFB1)–related hepatocellular carcinoma have not yet been elucidated.
Methods: We conducted a hospital-based case–control study, including 1,706 hepatocellular carcinoma cases and 2,270 controls without any liver diseases or tumors, to assess the association between 74 polymorphisms in ADAMTS5 and AFB1-related hepatocellular carcinoma risk and prognosis. Genotype, mRNA levels, and TP53 gene mutation (TP53M) related to AFB1 exposure were tested using TaqMan-PCR or sequencing technique. ADAMTS5 protein level and microvessel density were analyzed by IHC.
Results: Among these 74 polymorphisms, only rs2830581 affected hepatocellular carcinoma risk. Compared with the homozygote of rs2830581 G alleles (rs2830581-GG), the genotypes of rs2830581 A alleles (rs2830581-GA or -AA) increased hepatocellular carcinoma risk (OR: 1.85 and 4.40; 95% CI: 1.57–2.19 and 3.43–5.64, respectively). Significant interactive effects between risk genotypes and AFB1 exposure status were also observed in the joint effects analysis. Furthermore, the rs2830581 polymorphism modified the tumor recurrence-free survival and overall survival of patients. This polymorphism not only affected pathologic features of hepatocellular carcinoma such as tumor dedifferentiation and microvessel density, but also modified ADAMTS5 expression and the effects of transarterial chemoembolization treatment on hepatocellular carcinoma.
Conclusions: These results suggest ADAMTS5 polymorphisms may be risk and prognostic biomarkers of AFB1-related hepatocellular carcinoma, and rs2830581 is a potential candidate.
Impact: Our findings support the hypothesis that ADAMTS5 rs2830581 polymorphism modifies AFB1-related hepatocellular carcinoma risk and prognosis. Cancer Epidemiol Biomarkers Prev; 25(2); 334–43. ©2015 AACR.
Modulation of Frontoparietal Neurovascular Dynamics in Working Memory
Authors: Ardestani Allen , Shen Wei , Darvas Felix , Toga Arthur W. , Fuster Joaquin M. 
Published: December 2015

Abstract
Our perception of the world is represented in widespread, overlapping, and interactive neuronal networks of the cerebral cortex. A majority of physiological studies on the subject have focused on oscillatory synchrony as the binding mechanism for representation and transmission of neural information. Little is known, however, about the stability of that synchrony during prolonged cognitive operations that span more than just a few seconds. The present research, in primates, investigated the dynamic patterns of oscillatory synchrony by two complementary recording methods, surface field potentials (SFPs) and near-infrared spectroscopy (NIRS). The signals were first recorded during the resting state to examine intrinsic functional connectivity. The temporal modulation of coactivation was then examined on both signals during performance of working memory (WM) tasks with long delays (memory retention epochs). In both signals, the peristimulus period exhibited characteristic features in frontal and parietal regions. Examination of SFP signals over delays lasting tens of seconds, however, revealed alternations of synchronization and desynchronization. These alternations occurred within the same frequency bands observed in the peristimulus epoch, without a specific correspondence between any definite cognitive process (e.g., WM) and synchrony within a given frequency band. What emerged instead was a correlation between the degree of SFP signal fragmentation (in time, frequency, and brain space) and the complexity and efficiency of the task being performed. In other words, the incidence and extent of SFP transitions between synchronization and desynchronization—rather than the absolute degree of synchrony—augmented in correct task performance compared with incorrect performance or in a control task without WM demand. An opposite relationship was found in NIRS: increasing task complexity induced more uniform, rather than fragmented, NIRS coactivations. These findings indicate that the particular features of neural oscillations cannot be linearly mapped to cognitive functions. Rather, information and the cognitive operations performed on it are primarily reflected in their modulations over time. The increased complexity and fragmentation of electrical frequencies in WM may reflect the activation of hierarchically diverse cognits (cognitive networks) in that condition. Conversely, the homogeneity in coherence of NIRS responses may reflect the cumulative vascular reactions that accompany that neuroelectrical proliferation of frequencies and the longer time constant of the NIRS signal. These findings are directly relevant to the mechanisms mediating cognitive processes and to physiologically based interpretations of functional brain imaging.
Climatology, Synoptic Conditions, and Misanalyses of Mississippi River Valley Drylines
Authors: Duell Rebecca S. , Van Den Broeke Matthew S. 
Published: December 2015

Abstract
The dryline is an important focal point for convection initiation. Although drylines most commonly occur on the southern Great Plains, dryline passages and subsequent severe weather outbreaks have been documented in the Mississippi River valley. This study presents a 15-yr (1999–2013) climatology of these Mississippi River valley drylines and associated severe weather. Additionally, synoptic patterns are identified that may result in drylines moving atypically far eastward into the Mississippi River valley. In total, 39 Mississippi River valley drylines (hereafter referred to as MRV drylines) were identified from the North American Regional Reanalysis (NARR) dataset through the study period. Mean and anomaly synoptic composites were created for these drylines. MRV dryline events typically occur under synoptically active conditions with an amplified upper-air pattern, a 500-hPa shortwave trough to the west or northwest of the dryline, and a strong surface cyclone to the north. These boundaries are often misanalyzed or inconsistently analyzed as cold fronts, stationary fronts, or trough axes on surface maps; of the 33 cases of identified MRV drylines for which the Weather Prediction Center archived analyses were available, only 6 were correctly analyzed as drylines. Drylines moving into the Mississippi River valley often result in severe weather outbreaks in the Mississippi River valley, the Midwest, and the southeastern United States.
Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo
Authors: Czuczman Natalie M. , Barth Matthew J. , Gu Juan , Neppalli Vishala , Mavis Cory , Frys Sarah E. , Hu Qiang , Liu Song , Klener Pavel , Vockova Petra , Czuczman Myron S. , Hernandez-Ilizaliturri Francisco J. 
Published: December 2015

Key PointsPevonedistat (MLN4924), a NEDD8-activating enzyme inhibitor, is active in MCL preclinical models and potentiates rituximab activity. Our findings support further investigation of pevonedistat with or without rituximab in the treatment of MCL.
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease
Authors: Vinchi Francesca , Costa da Silva Milene , Ingoglia Giada , Petrillo Sara , Brinkman Nathan , Zuercher Adrian , Cerwenka Adelheid , Tolosano Emanuela , Muckenthaler Martina U. 
Published: December 2015

Key PointsHeme and iron induce macrophage phenotypic switching toward an M1 proinflammatory phenotype. By scavenging free heme, hemopexin reverts heme-induced proinflammatory activation of macrophages in a mouse model of sickle cell disease.
A people-centric framework for mobile augmented reality systems (MARS) design: ArcHIVE 4Any
Authors: Kavakli Manolya 
Published: December 2015

AbstractThis paper introduces a generic people-centric mobile augmented reality systems (MARS) framework to leverage the application system design and implementation. Proposed 4Any framework could be used as a meta architecture to guide the development of MARS. The main challenge in MARS design is providing a generic framework flexible enough to allow rapid development of applications to be used by different types of people. The paper demonstrates how 4Any framework has been applied in an ongoing project ArcHIVE 4Any using two field studies in Chalon sur Saone, France and Anzac Cove, Gallipoli, Turkey. ArcHIVE 4Any was implemented by using Django framework. The goal of this paper is to demonstrate the potential of the framework in terms of flexibility of system architecture and usability in recording landmarks in a number of heritage sites. In 4Any Framework we assume learning has to occur anywhere, anyway, anytime for anybody. The actors in this framework are specified as Instructor, Learner, Device and Programmer. Each actor initiates an action with respective entities Information, Media, Location and Time. What mediates each action is the metadata layer between the entities and people profiles using the same system. Metadata layer provides mapping between the underlying structures and definitions of associated content between the actors and entities. This way, each user sees a different face of the same system. The 4Any system architecture separates the system into four modules: Instruction, Learning, Device and Coding. There are 2 main sides of this framework to support learning anytime, anywhere, anyway by anybody: Pedagogical and Technological. The framework is composed of four layers that correspond to each row: Actors, Profiles, Metadata to be shared, and Scenario. With the rapid development of mobile technologies, new features of mobile devices will become available. The usability test results with ten Instructor profiles suggest that 4Any framework will be able serve as a vehicle for people-centric computing, to be used by anybody, anywhere, anyway, and anytime. Thus, the paper contributes to the knowledge in Human Centric Computing by taking into account multiple users and presenting different faces to each user demonstrating an example of the People Centric Computing paradigm.
WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development in Drosophila
Authors: Brinkmann Klaus , Winterhoff Moritz , Önel Susanne-Filiz , Schultz Jörg , Faix Jan , Bogdan Sven 
Published: December 2015

ABSTRACT
Wiskott–Aldrich syndrome proteins (WASPs) are nucleation-promoting factors (NPF) that differentially control the Arp2/3 complex. In Drosophila, three different family members, SCAR (also known as WAVE), WASP and WASH (also known as CG13176), have been analyzed so far. Here, we characterized WHAMY, the fourth Drosophila WASP family member. whamy originated from a wasp gene duplication and underwent a sub-neofunctionalization. Unlike WASP, we found that WHAMY specifically interacted with activated Rac1 through its two CRIB domains, which were sufficient for targeting WHAMY to lamellipodial and filopodial tips. Biochemical analyses showed that WHAMY promoted exceptionally fast actin filament elongation, although it did not activate the Arp2/3 complex. Loss- and gain-of-function studies revealed an important function of WHAMY in membrane protrusions and cell migration in macrophages. Genetic data further implied synergistic functions between WHAMY and WASP during morphogenesis. Double mutants were late-embryonic lethal and showed severe defects in myoblast fusion. Trans-heterozygous mutant animals showed strongly increased defects in sensory cell fate specification. Thus, WHAMY is a novel actin polymerase with an initial partitioning of ancestral WASP functions in development and subsequent acquisition of a new function in cell motility during evolution.
Emery–Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane
Authors: Pfaff Janine , Rivera Monroy Jhon , Jamieson Cara , Rajanala Kalpana , Vilardi Fabio , Schwappach Blanche , Kehlenbach Ralph H. 
Published: December 2015

ABSTRACT
Emerin is a tail-anchored protein that is found predominantly at the inner nuclear membrane (INM), where it associates with components of the nuclear lamina. Mutations in the emerin gene cause Emery–Dreifuss muscular dystrophy (EDMD), an X-linked recessive disease. Here, we report that the TRC40/GET pathway for post-translational insertion of tail-anchored proteins into membranes is involved in emerin-trafficking. Using proximity ligation assays, we show that emerin interacts with TRC40 in situ. Emerin expressed in bacteria or in a cell-free lysate was inserted into microsomal membranes in an ATP- and TRC40-dependent manner. Dominant-negative fragments of the TRC40-receptor proteins WRB and CAML (also known as CAMLG) inhibited membrane insertion. A rapamycin-based dimerization assay revealed correct transport of wild-type emerin to the INM, whereas TRC40-binding, membrane integration and INM-targeting of emerin mutant proteins that occur in EDMD was disturbed. Our results suggest that the mode of membrane integration contributes to correct targeting of emerin to the INM.
A Phenazaborin-Based High-Efficiency Blue Delayed Fluorescence Material
Authors: Park In Seob , Numata Masaki , Adachi Chihaya , Yasuda Takuma 
Published: December 2015

Abstract
A highly efficient blue thermally activated delayed fluorescence (TADF) material based on phenazaborin and spiroacridan units was developed. A blue-emitting organic light-emitting diode containing the phenazaborin derivative as a TADF emitter exhibited a high external electroluminescence quantum efficiency of 18.2%.
High-Frequency EPR Studies on Polymer Chain Morphology in Dip-Coated Films of Poly(3-hexylthiophene)/Fullerene Bulk-Heterojunctions
Authors: Matsuoka Hideto , Mizutani Shinichi , Watanabe Chika , Yamauchi Seigo 
Published: December 2015

Abstract
Polymer chain morphology and its response to annealing were investigated in terms of g-tensor anisotropy in poly(3-hexylthiophene) (P3HT)/fullerene blend films fabricated by dip coating. The g-anisotropy highly resolved by W-band (94 GHz) electron paramagnetic resonance (EPR) spectroscopy enabled us to precisely determine the molecular orientation of P3HT. The substrate dependence of the morphology was also investigated by W-band EPR spectroscopy. The determined morphology and EPR line width provided insight into the growth of P3HT crystalline domains, which was correlated with solar cell performance.
The Contract Lifecycle-Practical Experience of Implementing
Authors: Шабалова  , Shabalova L. 
Published: December 2015

This article is devoted to the study of modern forms of public-private
partnership — contract life cycle. The experience of world con-tract of the
life cycle is considered on the example of great Britain, the Netherlands, Spain,
Russia. Describes a series of projects under a contract model of the life cycle
in construction of objects of transport and sports infrastructure, both in Europe
and in Russia.
Linearization of Hue Value on The Surface of Thermochromic Liquid Crystal With Variation of Temperature
Authors: Suryantari Risti , F Flaviana 
Published: December 2015

<p class="AbstractText">This research has observed a linear relation of hue value on the surface of a Thermochromic Liquid Crystal (TLC), with variation of temperature, based on statistic value of hue image. In this research we use ample of TLC with temperature range 25<sup>0</sup>-30<sup>0 </sup>C and 30<sup>0</sup>-35<sup>0 </sup>C. The original image in RGB format is converted to HSV (hue, saturation, value) and by taking hue without saturation and value, then the hue image is processed using Matlab2013a based on a mathematical morphology with opening and closing for the main process to get better images. The final image of each temperature variation can be distinguished based on the statistic value of each image. The value of max and mean hue increases by increasing temperature for each sample. Both samples tend to have the same linearization based on its mean value.</p>
Modification of Materials and Thickness Layer of Radial Piercing Beamport (RPB) Reflector on Kartini Reactor for Boron Neutron Capture Therapy (BNCT)
Authors: F Octaviana Erawati , R Riyatun , S Suharyana 
Published: December 2015

<p>Modification of materials and thicknesses reflector RPB of Kartini reactor has been done to support cancer therapy with BNCT method. Modifications have been investigated by computer simulation method based on software MCNP5. Neutron beam for BNCT must be fulfill the criteria recommended by International Atomic Energy Agency (IAEA), two of which are n.cm<sup>-2</sup>.s<sup>-1</sup> and . Before the modification of the neutron beam done, the measurements in the end of the RPB indicate that n.cm<sup>-2</sup>.s<sup>-1</sup> and . These conditions were not fulfilling the requirements of the IAEA, so that the modification of the reflector material and thickness layer of RPB should be done. Those modifications were done by varying the materials PbF2, Pb-nat, 209Bi, Ni-nat (95%) and Fe-nat. The simulation result showed if the material Ni-nat (95%) on the thickness 1.5 cm was use as a coating material reflector optimally. The results after the modification showed that increased 7,54% with the increase amounted to n.cm<sup>-2</sup>.s<sup>-1</sup>. decrease 21,45%, then decreasing the value of became 1,70. After the modification the results has not yet fulfill the criteria of the IAEA. Because of the reflector was not the only guide neutron beam. Moderator and filter have not been optimized to deliver results for files that match the criteria of the IAEA for BNCT. Therefore, in future studies modified with the addition of a neutron moderator and also filter is expected to help increasing the quantity of and decreasing of .</p>
Preparation and investigation of mefenamic acid – polyethylene glycol – sucrose ester solid dispersions
Authors: Fülöp Ibolya , Gyéresi Árpád , Kiss Lóránd , Deli Mária A. , Croitoru Mircea Dumitru , Szabó-Révész Piroska , Aigner Zoltán 
Published: December 2015

Abstract
Mefenamic acid (MA) is a widely used non-steroidal antiinflammatory (NSAID) drug. The adverse effects typical of NSAIDs are also present in the case of MA, partly due to its low water solubility. The aim of this study was to increase the water solubility of MA in order to influence its absorption and bioavailability. Solid dispersions of MA were prepared by the melting method using polyethylene glycol 6000 and different types (laurate, D-1216; palmitate, P-1670; stearate, S-1670) and amounts of sucrose esters as carriers. The X-ray diffraction results show that MA crystals were not present in the products. Dissolution tests carried out in artificial intestinal juice showed that the product containing 10 % D-1216 increased water solubility about 3 times. The apparent permeability coefficient of MA across human Caco-2 intestinal epithelial cell layers was high and, despite the difference in solubility, there was no further increase in drug penetration in the presence of the applied additives.
Risperidone oral disintegrating mini-tablets: A robust-product for pediatrics
Authors: El-Say Khalid M. , Ahmed Tarek A. , Abdelbary Maged F. , Ali Bahaa E. , Aljaeid Bader M. , Zidan Ahmed S. 
Published: December 2015

Abstract
This study was aimed at developing risperidone oral disintegrating mini-tablets (OD-mini-tablets) as age-appropriate formulations and to assess their suitability for infants and pediatric use. An experimental Box-Behnken design was applied to assure high quality of the OD-mini-tablets and reduce product variability. The design was employed to understand the influence of the critical excipient combinations on the production of OD-mini-tablets and thus guarantee the feasibility of obtaining products with dosage form uniformity. The variables selected were mannitol percent in Avicel (X1), swelling pressure of the superdisintegrant (X2), and the surface area of Aerosil as a glidant (X3). Risperidone-excipient compatibilities were investigated using FTIR and the spectra did not display any interaction. Fifteen formulations were prepared and evaluated for preand post-compression characteristics. The prepared ODmini- tablet batches were also assessed for disintegration in simulated salivary fluid (SSF, pH 6.2) and in reconstituted skimmed milk. The optimized formula fulfilled the requirements for crushing strength of 5 kN with minimal friability, disintegration times of 8.4 and 53.7 s in SSF and skimmed milk, respectively. This study therefore proposes the risperidone OD-mini-tablet formula having robust mechanical properties, uniform and precise dosing of medication with short disintegration time suitable for pediatric use.