bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solar energetic particle warnings from a coronagraph
Authors: St. Cyr O. C. , Posner A. , Burkepile J. T. 
Published: January 2017

AbstractWe report here the concept of using near‐real time observations from a coronagraph to provide early warning of a fast coronal mass ejection (CME) and the possible onset of a solar energetic particle (SEP) event. The 1 January 2016, fast CME, and its associated SEP event are cited as an example. The CME was detected by the ground‐based K‐Cor coronagraph at Mauna Loa Solar Observatory and by the SOHO Large Angle and Spectrometric Coronagraph. The near‐real‐time availability of the high‐cadence K‐Cor observations in the low corona leads to an obvious question: “Why has no one attempted to use a coronagraph as an early warning device for SEP events?” The answer is that the low image cadence and the long latency of existing spaceborne coronagraphs make them valid for archival studies but typically unsuitable for near‐real‐time forecasting. The January 2016 event provided favorable CME viewing geometry and demonstrated that the primary component of a prototype ground‐based system for SEP warnings is available several hours on most days. We discuss how a conceptual CME‐based warning system relates to other techniques, including an estimate of the relative SEP warning times, and how such a system might be realized.
Tip‐Enhanced Raman Spectroscopy to Distinguish Toxic Oligomers from Aβ1–42 Fibrils at the Nanometer Scale
Authors: Bonhommeau Sébastien , Talaga David , Hunel Julien , Cullin Christophe , Lecomte Sophie 
Published: January 2017

AbstractFor the first time, natural Aβ1–42 fibrils (WT) implicated in Alzheimer's disease, as well as two synthetic mutants forming less toxic amyloid fibrils (L34T) and highly toxic oligomers (oG37C), are chemically characterized at the scale of a single structure using tip‐enhanced Raman spectroscopy (TERS). While the proportion of TERS features associated with amino acid residues is similar for the three peptides, a careful examination of amide I and amide III bands allows us to clearly distinguish WT and L34T fibers organized in parallel β‐sheets from the small and more toxic oG37C oligomers organized in anti‐parallel β‐sheets.
Trapping Rare and Elusive Phosphinidene Chalcogenides
Authors: Graham Cameron M. E. , Pritchard Taylor E. , Boyle Paul D. , Valjus Juuso , Tuononen Heikki M. , Ragogna Paul J. 
Published: January 2017

AbstractFour‐membered rings with a P2Ch2 core (Ch=S, Se) and phosphorus in the +3 oxidation state have been synthesized. The utility of these rings as a source of monomeric phosphinidene chalcogenides was probed by the addition of an N‐heterocyclic carbene, resulting in a base‐stabilized phosphinidene sulfide. Similarly, persistence of the phosphinidene selenide in solution was shown through cycloaddition chemistry with 2,3‐dimethylbutadiene at elevated temperatures. The observed reactivity was explained by detailed computational work that established the conditions upon which the P2Ch2 rings can liberate phosphinidene chalcogenides.
A targeted next‐generation sequencing in the molecular risk stratification of adult acute myeloid leukemia: implications for clinical practice
Authors: Lin Po‐Han , Li Huei‐Ying , Fan Sheng‐Chih , Yuan Tzu‐Hang , Chen Ming , Hsu Yu‐Hua , Yang Yu‐Hsuan , Li Long‐Yuan , Yeh Su‐Peng , Bai Li‐Yuan , Liao Yu‐Min , Lin Chen‐Yuan , Hsieh Ching‐Yun , Lin Ching‐Chan , Lin Che‐Hung , Lien Ming‐Yu , Chen Tzu‐Ting , Ni Yen‐Hsuan , Chiu Chang‐Fang 
Published: January 2017

AbstractConventional cytogenetics can categorize patients with acute myeloid leukemia (AML) into favorable, intermediate, and unfavorable‐risk groups; however, patients with intermediate‐risk cytogenetics represent the major population with variable outcomes. Because molecular profiling can assist with AML prognosis and next‐generation sequencing allows simultaneous sequencing of many target genes, we analyzed 260 genes in 112 patients with de novo AML who received standard treatment. Multivariate analysis showed that karyotypes and mutation status of TET2, PHF6, KIT, and NPM1mutation/FLT3‐ internal tandem duplication (ITD)negative were independent prognostic factors for the entire cohort. Among patients with intermediate‐risk cytogenetics, patients with mutations in CEBPAdouble mutation, IDH2, and NPM1 in the absence of FLT3‐ITD were associated with improved Overall survival (OS), similar to those with favorable‐risk cytogenetics; patients with mutations in TET2, RUNX1, ASXL1, and DNMT3A were associated with reduced OS, similar to those with unfavorable‐risk cytogenetics. We concluded that integration of cytogenetic and molecular profiling improves prognostic stratification of patients into three groups with more distinct prognoses (P < 0.001) and significantly reduces the number of patients classified as intermediate risk. In addition, our study demonstrates that next‐generation sequencing (NGS)‐based multi‐gene sequencing is clinically applicable in establishing an accurate risk stratification system for guiding therapeutic decisions.
How trust in financial supplier information impacts young adults' financial information involvement: The moderating roles of product savings risk and social norm
Authors: Hansen Torben 
Published: January 2017

AbstractAlthough consumers' risk‐taking, supplier trust, social norms and information involvement are central to much of thought in the financial market and consumer economic literature, it is not known how the interplay between consumers' trust in supplier information, risk‐taking behaviour and social norm may influence information involvement. This research contributes to the consumer economic literature by investigating how product savings risk and social norm affect the relationship between young adults' trust in supplier information and their information involvement. On the basis of two samples with young adults who recently have purchased a low‐risk savings product (n = 641) and a high‐risk savings product (n = 219), respectively, several results are obtained. It is found that both product savings risk and social norm positively moderate the relationship between young adults' trust in supplier information and their information involvement. In addition, the results indicate that the three‐way interaction between trust in supplier information, products savings risk and social norm has a positive effect on information involvement. As direct implications, financial authorities and financial service managers should especially consider investing additional resources in developing information trust for high‐risk savings products and should also take social norms into account when considering young adults' high‐risk‐taking behaviour. Copyright © 2017 John Wiley & Sons, Ltd.
Water‐Soluble Polymer Nanoparticles Constructed by Three‐Component Self‐Assembly: An Efficient Theranostic Agent for Phosphorescent Imaging and Photodynamic Therapy
Authors: Yang Qi , Shi Min , Zhao Heng , Lin Jiaomin , An Lu , Cui Lili , Yang Hong , Zhou Zhiguo , Tian Qiwei , Yang Shiping 
Published: January 2017

AbstractWater‐soluble polymer nanoparticles NP‐1 and NP‐2 were prepared by using a three‐component self‐assembly of an iridium complex, poly(4‐vinyl pyridine‐b‐ethylene oxide) (P4VP‐b‐PEO), and methane sulfonic acid (MSA). Due to the unique metal‐ligand charge‐transfer transition property and the heavy‐atom effect of the iridium atom, NP‐1 and NP‐2 showed bright phosphorescence and generated the singlet oxygen (1O2) species effectively under visible‐light irradiation (λ>400 nm) with a power density of 300 mW cm−2. NP‐2, an example of the polymer nanoparticles, showed minimal cytotoxic activity in the dark. Laser confocal fluorescence and flow‐cytometry microscopy experiments demonstrated that NP‐2 could be taken up by a model cancer‐cell line of 4T1 cells, which could be used as a phosphorescent probe for cell imaging by preferentially staining the cytoplasm. After 6 hours of incubation with NP‐2 (100 μg mL−1), the cell viability of 4T1 cells decreased to approximately 10 % upon visible‐light irradiation (λ>400 nm, 300 mW cm−2) only for 10 minutes as a result of the generation of the 1O2 species, thus indicating a proof of concept for effective photodynamic therapy for cancer cells.
Chemoselective Henry Condensations Catalyzed by Artificial Carboligases
Authors: Garrabou Xavier , Macdonald Duncan Stuart , Hilvert Donald 
Published: January 2017

AbstractThe promiscuity of de novo designed enzymes provides a privileged platform for diverse abiological reactions. In this work, we report the first example of a nitroolefin synthase that catalyzes the Henry condensation between aromatic aldehydes and nitromethane. Significant catalytic activity was discovered in the computationally designed and evolved carboligase RA95.5‐8, and mutations around the active site were shown to improve the reaction rate, demonstrating the potential to optimize the enzyme by directed evolution. This novel nitroolefin synthase could participate in complex biological cascades, whereby the highly tunable chemoselectivity could afford useful synthetic building blocks.
Use of Charge‐Charge Repulsion to Enhance π‐Electron Delocalization into Anti‐Aromatic and Aromatic Systems
Authors: Sumita Akinari , Gasonoo Makafui , Boblak Kenneth J. , Ohwada Tomohiko , Klumpp Douglas A 
Published: January 2017

AbstractA series of 9‐fluorenyl cations has been studied and it is shown that increasing charge on a heterocyclic substituent group enhances the anti‐aromatic character of the carbocation system. Similarly, a series of dibenzosuberenyl cations has been studied and increasing charge on a substituent group is shown to enhance aromatic character in the carbocation system. These studies include the direct observations of dicationic and tricationic species using stable‐ion conditions and low temperature NMR. The structures of these ions were further characterized using DFT calculations, confirming that highly charged organic ions may exhibit unusual distributions of π‐electrons and delocalization of electrons in 4n or 4n+2 π‐systems.
Synthesis and Biological Evaluation of Novel 2‐Aminonicotinamide Derivatives as Antifungal Agents
Authors: Ni Tingjunhong , Li Ran , Xie Fei , Zhao Jing , Huang Xin , An Maomao , Zang Chengxu , Cai Zhan , Zhang Dazhi , Jiang Yuanying 
Published: January 2017

AbstractBased on the structures of the reported compounds G884 [N‐(3‐(pentan‐2‐yloxy)phenyl)nicotinamide], E1210 [3‐(3‐(4‐((pyridin‐2‐yloxy)methyl)benzyl)isoxazol‐5‐yl)pyridin‐2‐amine], and 10 b [2‐amino‐N‐((5‐(3‐fluorophenoxy)thiophen‐2‐yl)methyl)nicotinamide], which inhibit the biosynthesis of glycosylphosphatidylinositol (GPI)‐anchored proteins in fungi, a series of novel 2‐aminonicotinamide derivatives were designed, synthesized, and evaluated for in vitro antifungal activity. Most of these compounds were found to exhibit potent in vitro antifungal activity against Candida albicans, with MIC80 values ranging from 0.0313 to 4.0 μg mL−1. In particular, compounds 11 g [2‐amino‐N‐((5‐(((2‐fluorophenyl)amino)methyl)thiophen‐2‐yl)methyl)nicotinamide] and 11 h [2‐amino‐N‐((5‐(((3‐fluorophenyl)amino)methyl)thiophen‐2‐yl)methyl)nicotinamide] displayed excellent activity against C. albicans, with MIC80 values of 0.0313 μg mL−1, and exhibited broad‐spectrum antifungal activity against fluconazole‐resistant C. albicans, C. parapsilosis, C. glabrata, and Cryptococcus neoformans, with a MIC80 range of 0.0313–2.0 μg mL−1. Further studies by electron microscopy and laser confocal microscopy indicated that compound 11 g targets the cell wall and decreases GPI anchor content on the cell surface of C. albicans.
A survival guide to Landsat preprocessing
Authors: Young Nicholas E. , Anderson Ryan S. , Chignell Stephen M. , Vorster Anthony G. , Lawrence Rick , Evangelista Paul H. 
Published: January 2017

AbstractLandsat data are increasingly used for ecological monitoring and research. These data often require preprocessing prior to analysis to account for sensor, solar, atmospheric, and topographic effects. However, ecologists using these data are faced with a literature containing inconsistent terminology, outdated methods, and a vast number of approaches with contradictory recommendations. These issues can, at best, make determining the correct preprocessing workflow a difficult and time‐consuming task and, at worst, lead to erroneous results. We address these problems by providing a concise overview of the Landsat missions and sensors and by clarifying frequently conflated terms and methods. Preprocessing steps commonly applied to Landsat data are differentiated and explained, including georeferencing and co‐registration, conversion to radiance, solar correction, atmospheric correction, topographic correction, and relative correction. We then synthesize this information by presenting workflows and a decision tree for determining the appropriate level of imagery preprocessing given an ecological research question, while emphasizing the need to tailor each workflow to the study site and question at hand. We recommend a parsimonious approach to Landsat preprocessing that avoids unnecessary steps and recommend approaches and data products that are well tested, easily available, and sufficiently documented. Our focus is specific to ecological applications of Landsat data, yet many of the concepts and recommendations discussed are also appropriate for other disciplines and remote sensing platforms.
Rapid process synthesis supported by a unified modular software framework
Authors: Herold Sebastian , Krämer Dominik , Violet Norman , King Rudibert 
Published: January 2017

AbstractAlthough known to be very powerful, the widespread application of model‐based techniques is still significantly hampered in the area of bio‐processes. Reasons for this situation can be found along the whole chain to set up and implement such approaches. In a time‐consuming step, models are typically hand‐crafted. Whether alternatives of better models exist to actually fulfill the final goals is undocumented, most often even unknown. In a next step, model‐based process control methods are hand‐coded in an error‐prone procedure. For many of these methods given in the literature, only simulation studies are shown, leaving the interested reader with the unanswered question whether the implementation of a specific method in a real process is viable. As the potentially time‐consuming implementation of such a method presents a risk for a rapid process development, promising candidates may be overlooked. To remediate this unsatisfactory situation, a combination of theoretical methods and information technology is proposed here. By an exemplarily realized software tool, it is shown how such an environment helps to promote model‐based optimization, supervision, and control of bio‐processes and allows for an inexpensive test of new ideas as well in real‐life experiments. The contribution concentrates on an overview of a possible software architecture with respect to necessary methods and a meaningful information strategy, highlighting some of the more crucial building blocks. Experimental results exploiting parts of the proposed methods are given for a yeast strain synthesizing a product of industrial interest.
Birth characteristics of Syrian refugees and Turkish citizens in Turkey in 2015
Authors: Demirci Hakan , Yildirim Topak Nevruz , Ocakoglu Gokhan , Karakulak Gomleksiz Mehtap , Ustunyurt Emin , Ulku Turker Ayse 
Published: January 2017

AbstractObjectiveTo compare the birth characteristics of Syrian refugees with those of Turkish citizens.MethodsIn a retrospective study, data were obtained for singleton live births that occurred at a hospital in Bursa, Turkey, between June 1 and December 31, 2015. All Syrian refugees were eligible for inclusion; one Turkish citizen was included for each refugee.ResultsOverall, 545 Syrian refugees and 545 Turkish citizens were included. Cesarean delivery was undertaken for 176 (32.3%) Syrians and 235 (43.1%) Turks (P<0.001). Median neonatal birth weight was higher among Turkish citizens (3300 g, range 970–4720) than among Syrian refugees (3110 g, range 540–4790; P<0.001). Gestational diabetes was recorded for 42 (7.7%) Turkish citizens and 9 (1.7%) Syrian refugees (P<0.001). Pre‐eclampsia affected 21 (3.9%) Turkish citizens and 8 (1.5%) Syrians (P=0.014).ConclusionCesarean delivery is more common among pregnant Turkish citizens than among Syrian refugees. Other notable differences between the groups were recorded.
The Treatment of Oligospermia with Various Dosage Regimes of Gonadotropins
Authors: Diejomaoh Michael F. E. , Bichacho Shlomo , Epstein Jeanne A. , Sobrero Acquiles J. 
Published: January 2017

Diejomaoh, M. F. E., Bichacho, Sh., Epstein, J. A. and Sobrero, A. J. (All formerly of the Margaret Sanger Research Bureau, 17 West 16th Street, New York, NY, USA). The treatment of oligospermia with various dosage regimes of gonadotropins.Int J Gynaecol Obstet 13: 241–248, 1975.The report of 96 normogonadotropic oligospermic infertile males, 50 of whom were treated with high HCG doses of 10000 units twice weekly for 10 weeks, 24 of whom were treated with moderate HCG dose of 5000 units twice weekly for 10 weeks and 22 of whom received combination therapy of HCG 5000 units and PMS 750 units twice weekly for 10 weeks is here presented. In the first group, seven patients (14%) had improvement in seminal quality with a single subsequent pregnancy whereas in the latter two groups, 11 patients (23.9%) had improvement in seminal quality with six subsequent pregnancies. The overall pregnancy rate in the series was 23.95%; the overall pregnancy rates for the two groups of patients were virtually equal, although most of the pregnancies in the high HCG dosage schedule occurred in the absence of seminal improvement. Varicocelectomy did not improve the pregnancy rate in this series. Female fertility problems did not hinder the occurrence of pregnancy in this series as such female fertility problems were usually corrected. No correlation was found between testicular pathology and improvement in semen quality.
Female Sterilization via Laparoscopy
Authors: Madrigal Vernon , Edelman David A. , Goldsmith Alfredo , Brenner William E. 
Published: January 2017

Madrigal, V., Edelman, D. A., Goldsmith, A. & Brenner, Wm. E. (Asociación Demográfica Salvadoreña, San Salvador, El Salvador, International Fertility Research Program, Chapel Hill, N. C., and the Dept. of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, N. C., USA). Female sterilization via laparoscopy: A long‐term follow‐up study.Int J Gynaecol Obstet 13: 268–272, 1975.While interval female sterilization via laparoscopy appears to be a safe and effective procedure, long‐term follow‐up studies of this method have not been reported. To determine the incidence of gynecological abnormalities and failure after laparoscopic sterilization with electrocoagulation and division of the tubes, pertinent data were analyzed from 635 consecutive patients sterilized by this technique at the Asociación Demográfica Salvadoreña, El Salvador, in 1972–73. Of these patients, 86.2% have been seen for at least one follow‐up examination 4–31 months post‐sterilization. Significant gynecological abnormalities occurred in 2.4% of the cases within 4 to 8 months, in 3.0% of the cases within 15 to 21 months, and in 1.4% of the cases within 22 to 31 months of sterilization. Some changes in menstrual cycle function were noted. There was an increase over time in the proportion of patients who developed irregular menstrual cycles and dysmenorrhea. The failure rate of the procedure was 0.7%. Laparoscopic sterilization with electrocoagulation of the tubes appears to result in clinically acceptable rates of long‐term complications. To adequately evaluate the long‐term sequelae of sterilization, appropriate, long‐term comparative studies of various methods and techniques of tubal occlusion, including hysterectomy, will have to be conducted.
Prediction of One Minute APGAR Score by Fetal Heart Rate Analysis: a Comparison between 3 Methods
Authors: Sturbois G. , Tournaire M. , Breart G. , Gaultier D. , Sureau C. 
Published: January 2017

ABSTRACTSturbois, G., Tournaire, M., Bréart, G., Gaultier, D. and Sureau, C. (Baudelocque Research Group (Professeur Lepage), 123, boulevard de Port‐Royal, 75014‐Paris, France).
Sterilization by Minilaparotomy in not Recently Pregnant Patients
Authors: Brenner William E. , Dingfelder James R. 
Published: January 2017

ABSTRACTSterilization of the not recently pregnant patient can be performed with the use of special techniques through a small abdominal incision (minilaparotomy), using local anesthesia, without the need for overnight hospitalization, and resulting in low rates of morbidity. Patient selection, counselling, evaluation, and preparation are discussed, as well as types of analgesia and anesthesia, the special equipment needed, different techniques of tubal occlusion, and the effectiveness and complications of the procedure. A procedure is detailed which requires the use of a uterine elevator with a speculum in the incision. The history, potential future developments and the advantages and disadvantages of performing minilaparotomy relative to other types of sterilization are discussed.
Fetal Movements Recorder, Use and Indications
Authors: Sadovsky Eliahu , Polishuk Wolfe Z. , Yaffe Haim , Adler David , Pachys Fred , Mahler Yona 
Published: January 2017

ABSTRACTA new device for recording fetal movements is presented. This device is composed of 2 sensors, incorporating a highly sensitive piezoelectric material. It is sensitive to rapid straining forces such as fetal movements and relatively insensitive to steady, slow movements such as uterine contractions and maternal respiratory movements. In this study of 20 women, the sensors were placed on 2 different zones of the abdomen, usually above the umbilicus. There was a good correlation between fetal movements recorded by the device and those felt by the patients. Seventy percent of all observed fetal movements recorded by the device were registered simultaneously by the women. The device recorded 90.4% and the women recorded 79.7% of all such movements.
Induction of Abortion by Intrauterine Administration of Prostaglandin via Laparoscopy with Concurrent Sterilization
Authors: Morad M. , Toppozada M. 
Published: January 2017

ABSTRACTThis is a preliminary report of a method of inducing abortion at 12 to 15 weeks' gestation, a period when none of the currently available methods are wholly satisfactory. The authors investigated both prostaglandin F2α (PGF2α) and 15‐methyl PGF2α injected intramyometrially and intraamniotically under laparoscopic visualization prior to sterilization as a means of inducing abortion. They conclude that the results from this small series (13 patients) indicate that this is a practicable method for abortion combined with sterilization for patients at 10 to 15 weeks' gestation and recommend that further comparative studies be undertaken.
Inducing Labor with Oral Prostaglandin E2 Tablets
Authors: Ang Luan Thiam , Ng K. H. , Sivanesaratnam V. , Sinnathuray T. A. , Yusof K. 
Published: January 2017

ABSTRACTLabor was successfully induced by forewater amniotomy and oral administration of prostaglandin E2 tablets in 91.3% of 153 women with singleton pregnancies. Deliveries occurred within 12 hours for more than 90% of the successfully induced patients. Although not statistically significant, a higher pelvic score appeared to be associated with shorter induction‐to‐delivery intervals. There were no harmful side effects for either mother or baby; only 14.5% experienced minor side effects, primarily gastrointestinal upsets.