bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant Enzalutamide Prior to Prostatectomy
Authors: Montgomery Bruce , Tretiakova Maria S. , Joshua Anthony M. , Gleave Martin E. , Fleshner Neil , Bubley Glenn J. , Mostaghel Elahe A. , Chi Kim N. , Lin Daniel W. , Sanda Martin , Novotny William , Wu Kenneth , Kantoff Philip W. , Marck Brett T. , Plymate Stephen , Balk Steven P. , Nelson Peter S. , Matsumoto Alvin M. , Lis Rosina T. , Kibel Adam , Haas Gabriel P. , Krivoshik Andrew , Hannah Alison , Taplin Mary-Ellen 
Published: November 2016

Abstract
Purpose: Prostate cancer is dependent on androgen receptor (AR) activation. Optimal AR antagonism may effectively cytoreduce local disease and suppress or eliminate micrometastases. We evaluated neoadjuvant therapy prior to prostatectomy with the potent AR antagonist enzalutamide (enza) either alone or in combination with dutasteride (dut) and leuprolide (enza/dut/luteinizing hormone-releasing hormone analogues [LHRHa]).
Experimental Design: Forty-eight of 52 men with intermediate or high-risk localized prostate cancer proceeded to prostatectomy after neoadjuvant enzalutamide or enza/dut/LHRHa for 6 months. We assessed pathologic complete response (pCR), minimal residual disease (MRD; ≤3 mm maximum diameter of residual disease), residual cancer burden (RCB), and expression of PSA and serum and tissue androgen concentrations. We compared the proportion of patients with pCR in each treatment arm with a historical control rate of 5%, based on previous reports of flutamide with LHRHa.
Results: In the enzalutamide arm, none of the 25 patients achieved pCR or MRD. In the enza/dut/LHRHa arm, one of 23 patients (4.3%) achieved pCR and 3 of 23 (13.0%) achieved MRD. Median RCB was higher in the enzalutamide arm than in the enza/dut/LHRHa arm (0.41 cm3 vs. 0.06 cm3, respectively). Tissue testosterone and dihydrotestosterone levels correlated with RCB. No adverse events leading to study drug discontinuation were reported.
Conclusions: Combination therapy with enza/dut/LHRHa resulted in pCR and MRD rates comparable with historical controls. Evidence of continued AR activity in residual tumor suggests that AR signaling may contribute to survival. Strategies to more effectively ablate AR activity are warranted to determine whether more substantial antitumor effects are observed. Clin Cancer Res; 23(9); 2169–76. ©2016 AACR.
INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure
Authors: Stewart Garrick C. , Kittleson Michelle M. , Patel Parag C. , Cowger Jennifer A. , Patel Chetan B. , Mountis Maria M. , Johnson Frances L. , Guglin Maya E. , Rame J. Eduardo , Teuteberg Jeffrey J. , Stevenson Lynne W. 
Published: November 2016

Background—
INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles provide important prognostic information for patients with advanced heart failure (HF) receiving mechanical support. The value of INTERMACS profiling has not been shown for patients followed on medical therapy for advanced HF at centers that also offer mechanical circulatory support.

Methods and Results—
This prospective, observational study enrolled 166 patients with chronic New York Heart Association class III–IV HF, ejection fraction ≤30%, and ≥1 HF hospitalization in the previous year, excluding patients listed for transplant or receiving chronic intravenous inotropic therapy. Subjects were followed for at least 12 months or until death, mechanical support, or transplant. Baseline features, quality of life, and outcomes were compared according to INTERMACS profile. Mean age was 57 years, ejection fraction 18%, and 57% had HF >5 years, whereas 23% of subjects were INTERMACS profile 4, 32% profile 5, and 45% profile 6/7. At 1 year, only 47% of this ambulatory advanced HF cohort remained alive on medical therapy. Patients in INTERMACS profile 4 were more likely to die or require mechanical support, with only 52% of these patients alive without support after the first 6 months. Profile 6/7 patients had 1-year survival of 84%, similar to outcomes for contemporary destination left ventricular assist device recipients. Quality of life using the indexed EuroQol score was poor across profiles 4 to 7, although severe limitation was less common than for ambulatory patients enrolled in INTERMACS before ventricular assist device implantation.

Conclusions—
Ambulatory patients with systolic HF, a heavy symptom burden, and at least 1 recent HF hospitalization are at high risk for death or left ventricular assist device rescue. INTERMACS profiles help identify ambulatory patients with advanced HF who may benefit from current mechanical support devices under existing indications.
Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism
Authors: Mahmoodi Bakhtawar K. , Cushman Mary , Anne Næss Inger , Allison Matthew A. , Bos Willem Jan , Brækkan Sigrid K. , Cannegieter Suzanne C. , Gansevoort Ron T. , Gona Philimon N. , Hammerstrøm Jens , Hansen John-Bjarne , Heckbert Susan , Holst Anders G. , Lakoski Susan G. , Lutsey Pamela L. , Manson JoAnn E. , Martin Lisa W. , Matsushita Kunihiro , Meijer Karina , Overvad Kim , Prescott Eva , Puurunen Marja , Rossouw Jacques E. , Sang Yingying , Severinsen Marianne T. , ten Berg Jur , Folsom Aaron R. , Zakai Neil A. 
Published: November 2016

Background:
Much controversy surrounds the association of traditional cardiovascular disease risk factors with venous thromboembolism (VTE).

Methods:
We performed an individual level random-effect meta-analysis including 9 prospective studies with measured baseline cardiovascular disease risk factors and validated VTE events. Definitions were harmonized across studies. Traditional cardiovascular disease risk factors were modeled categorically and continuously using restricted cubic splines. Estimates were obtained for overall VTE, provoked VTE (ie, VTE occurring in the presence of 1 or more established VTE risk factors), and unprovoked VTE, pulmonary embolism, and deep-vein thrombosis.

Results:
The studies included 244 865 participants with 4910 VTE events occurring during a mean follow-up of 4.7 to 19.7 years per study. Age, sex, and body mass index-adjusted hazard ratios for overall VTE were 0.98 (95% confidence interval [CI]: 0.89−1.07) for hypertension, 0.97 (95% CI: 0.88−1.08) for hyperlipidemia, 1.01 (95% CI: 0.89−1.15) for diabetes mellitus, and 1.19 (95% CI: 1.08−1.32) for current smoking. After full adjustment, these estimates were numerically similar. When modeled continuously, an inverse association was observed for systolic blood pressure (hazard ratio=0.79 [95% CI: 0.68−0.92] at systolic blood pressure 160 vs 110 mm Hg) but not for diastolic blood pressure or lipid measures with VTE. An important finding from VTE subtype analyses was that cigarette smoking was associated with provoked but not unprovoked VTE. Fully adjusted hazard ratios for the associations of current smoking with provoked and unprovoked VTE were 1.36 (95% CI: 1.22−1.52) and 1.08 (95% CI: 0.90−1.29), respectively.

Conclusions:
Except for the association between cigarette smoking and provoked VTE, which is potentially mediated through comorbid conditions such as cancer, the modifiable traditional cardiovascular disease risk factors are not associated with increased VTE risk. Higher systolic blood pressure showed an inverse association with VTE.
The effectiveness of Australia’s drug courts
Authors: Kornhauser Ryan 
Published: November 2016

Operating in Australia since 1999, drug courts are now present in the majority of Australian jurisdictions. This paper takes stock of the impact evaluations of Australia’s drug courts to date, and considers to what extent these evaluations support drug courts as being more effective than ‘conventional’ sanctions in reducing recidivism. While Australian evaluations indicate drug courts reduce recidivism more than conventional sanctions, certainty in these findings is tempered by mixed results and methodological limitations.
Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression
Authors: Wang Yan , Tye Anne E , Zhao Junli , Ma Dongqing , Raddant Ann C , Bu Fan , Spector Benjamin L , Winslow Nolan K , Wang Minyan , Russo Andrew F 
Published: November 2016

Objective The neuropeptide calcitonin gene-related peptide (CGRP) has now been established as a key player in migraine. However, the mechanisms underlying the reported elevation of CGRP in the serum and cerebrospinal fluid of some migraineurs are not known. A candidate mechanism is cortical spreading depression (CSD), which is associated with migraine with aura and traumatic brain injury. The aim of this study was to investigate whether CGRP gene expression may be induced by experimental CSD in the rat cerebral cortex. Methods CSD was induced by topical application of KCl and monitored using electrophysiological methods. Quantitative PCR and ELISA were used to measure CGRP mRNA and peptide levels in discrete ipsilateral and contralateral cortical regions of the rat brain 24 hours following CSD events and compared with sham treatments. Results The data show that multiple, but not single, CSD events significantly increase CGRP mRNA levels at 24 hours post-CSD in the ipsilateral rat cerebral cortex. Increased CGRP was observed in the ipsilateral frontal, motor, somatosensory, and visual cortices, but not the cingulate cortex, or contralateral cortices. CSD also induced CGRP peptide expression in the ipsilateral, but not contralateral, cortex. Conclusions Repeated CSD provides a mechanism for prolonged elevation of CGRP in the cerebral cortex, which may contribute to migraine and post-traumatic headache.
Simultaneous quantification of actin monomer and filament dynamics with modeling-assisted analysis of photoactivation
Authors: Kapustina Maryna , Read Tracy-Ann , Vitriol Eric A. 
Published: November 2016

ABSTRACT
Photoactivation allows one to pulse-label molecules and obtain quantitative data about their behavior. We have devised a new modeling-based analysis for photoactivatable actin experiments that simultaneously measures properties of monomeric and filamentous actin in a three-dimensional cellular environment. We use this method to determine differences in the dynamic behavior of β- and γ-actin isoforms, showing that both inhabit filaments that depolymerize at equal rates but that β-actin exists in a higher monomer-to-filament ratio. We also demonstrate that cofilin (cofilin 1) equally accelerates depolymerization of filaments made from both isoforms, but is only required to maintain the β-actin monomer pool. Finally, we used modeling-based analysis to assess actin dynamics in axon-like projections of differentiating neuroblastoma cells, showing that the actin monomer concentration is significantly depleted as the axon develops. Importantly, these results would not have been obtained using traditional half-time analysis. Given that parameters of the publicly available modeling platform can be adjusted to suit the experimental system of the user, this method can easily be used to quantify actin dynamics in many different cell types and subcellular compartments.
Surgical proficiency decreases the rate of healing abnormalities using anterior transobturator mesh in cystocele women
Authors: Yuk Jin-Sung , Kim Yong Jin , Yi Kyong Wook , Hur Jun-Young , Shin Jung-Ho 
Published: November 2016

Aims: The objective of this study is to report the outcomes of cystocele repair with anterior transobutrator mesh kits. Methods: 119 consecutive women with cystoceles were treated between January 2006 and November 2010 by a single surgeon at a university hospital using the anterior transobturator mesh kit procedure. Postoperative follow-up visits were scheduled at 1, 6, and 12 months after surgery. Results: A total of 114 women who were operated on with the anterior transobturator mesh kit completed 12 months of follow-up. The population had a mean age of 65.8 ± 7.0, a body mass index of 25.1 ± 3.0, and a parity average of 4.0 ± 1.7. An overall anatomic cure was reported for 108 patients (94.7%). The Ba point of the POP-Q exam used for grading cystoceles decreased significantly from 2.5 ± 1.6 cm to -2.8 ± 0.8 cm after 12 months (P < 0.01). One patient (0.9%) presented with bladder perforation, and five patients (4.4%) showed with healing abnormalities. Surgical case volume was negatively correlated with healing abnormalities after adjusting for age, body mass index, operation time, and parity (P = 0.15). Conclusion: The surgeon’s experience decreases the incidence of healing abnormalities using anterior transobturator mesh in cystocele women. The anatomical cure rate of anterior transobturator mesh is quite good.
On the Regularity of Alexandrov Surfaces with
Curvature Bounded Below
Authors: Ambrosio Luigi , Bertrand Jérôme 
Published: November 2016

Abstract
In this note, we prove that on a surface with Alexandrov’s curvature bounded below, the distance
derives from a Riemannian metric whose components, for any p ∈ [1, 2), locally belong to W1,p out of a
discrete singular set. This result is based on Reshetnyak’s work on the more general class of surfaces with
bounded integral curvature.
Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience
Authors: Zhang Shulan , Luo Jing , Li Ji , Wu Ziyan , Hu Chaojun , Li Ping , Deng Chuiwen , Zhang Fengchun , Qian Jiaming , Li Yongzhe 
Published: November 2016

AbstractBackground:Antibodies to saccharomyces cerevisiae (ASCA), antibodies to perinuclear anti-neutrophil cytoplasmic (pANCA), pancreatic autoantibodies (PAB) and antibodies against intestinal goblet cells (GAB) are important in diagnosing Crohn’s disease (CD) and ulcerative colitis (UC). However, little is known about their diagnostic value in real clinical practice in China. This retrospective study aimed to present our 2-year clinical experience with those biomarkers in diagnosis of CD and UC.Methods:A total of 140 patients with UC, 128 patients with CD, and 224 patients with intestinal associated diseases as disease controls were included. Serum ASCA were determined by ELISA. Serum pANCA, GAB, and PAB were tested by indirect immunofluorescent assay. Retrospective review of laboratory results and clinical information was performed.Results:ASCA and ASCA+/pANCA− showed poor abilities in differentiating CD from UC, CD from intestinal Behçet’s disease (BD), or CD from intestinal tuberculosis (ITB). In contrast, PAB exhibited good capacities in differentiating CD from UC, CD from intestinal BD, and CD from ITB. IgG pANCA demonstrated a high sensitivity and specificity in differentiating UC from CD. pANCA+/ASCA− or pANCA+/PAB− displayed a high sensitivity and specificity in differentiating UC from CD. GAB showed poor potential in differentiating UC from CD. PAB were positively correlated with early disease onset, ileocolonic disease, and perianal disease in CD patients.Conclusions:Our data suggest that pANCA and PAB are helpful in diagnosis of UC and CD, respectively, while ASCA and GAB were not. Our findings indicate a clear need for additional biomarkers for diagnosis of CD in China.
Stabilized Mixed Finite Element Methods for Linear Elasticity on Simplicial Grids in
ℝn
Authors: Chen Long , Hu Jun , Huang Xuehai 
Published: November 2016

Abstract
In this paper, we design two classes of stabilized mixed finite element methods for linear elasticity on simplicial grids.
In the first class of elements, we use

𝑯
⁢

(
div
,
Ω
;
𝕊
)

${\boldsymbol{H}(\operatorname{div},\Omega;\mathbb{S})}$

-

P
k

${P_{k}}$

and

𝑳
2

⁢

(
Ω
;

ℝ
n

)

${\boldsymbol{L}^{2}(\Omega;\mathbb{R}^{n})}$

-

P

k
-
1

${P_{k-1}}$

to approximate the stress and displacement spaces, respectively, for

1
≤
k
≤
n

${1\leq k\leq n}$

, and employ a stabilization technique in terms of
the jump of the discrete displacement over the edges/faces of the triangulation under consideration; in the second class of elements, we use

𝑯
0
1

⁢

(
Ω
;

ℝ
n

)

${\boldsymbol{H}_{0}^{1}(\Omega;\mathbb{R}^{n})}$

-

P
k

${P_{k}}$

to approximate the displacement space for

1
≤
k
≤
n

${1\leq k\leq n}$

, and adopt the stabilization technique suggested by Brezzi, Fortin, and Marini
[19]. We establish the discrete inf-sup conditions, and consequently present the a priori error analysis for them. The main ingredient for the analysis are two special interpolation operators, which can be constructed using a crucial

𝑯
⁢

(
div
)

${\boldsymbol{H}(\operatorname{div})}$

bubble function space of polynomials on each element. The feature of these methods is the low number of global degrees of freedom in the lowest order case. We present some numerical results to demonstrate the theoretical estimates.
Constructional contamination: How does it work and how do we measure it?
Authors: Pijpops Dirk , Van de Velde Freek 
Published: November 2016

Abstract
In this article, we introduce the effect of “constructional contamination”. In constructional contamination, a subset of the instances of a target construction deviate in their realization, due to a superficial resemblance they share with instances of a contaminating construction. We claim that this contaminating effect bears testimony to the hypothesis that language users do not always execute a full parse while interpreting and producing sentences. Instead, they may rely on what has been called “shallow parsing”, i. e., chunking the utterances into large, unanalyzed exemplars that may extend across constituent borders. We propose several measures to quantify constructional contamination in corpus data. To evaluate these measures, the Dutch partitive genitive is taken under scrutiny as a target construction of constructional contamination. In this case study, it is shown that neighboring constructions play a crucial role in determining the presence or absence of the -s suffix among instances of the partitive genitive. The different measures themselves, however, are not construction-specific, and can readily be used to track constructional contamination in other case studies as well.
Façade detergents as bicelle rim-forming agents for solution NMR spectroscopy
Authors: Mineev Konstantin S. , Nadezhdin Kirill D. , Goncharuk Sergey A. , Arseniev Alexander S. 
Published: November 2016

AbstractOut of all membrane mimetics available for solution nuclear magnetic resonance (NMR) spectroscopy, phospholipid bicelles are the most prospective. Unlike lipid-protein nanodiscs their size can be easily controlled over a wide range, and the exchange of matter between the particles can take place. However, recent studies revealed several major drawbacks of conventional 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) and DMPC/3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS) bicelles. First, size of such bicelles can increase dramatically upon heating, and, second, rim-forming detergents of bicelles can cause improper folding of the water-soluble globular domains of membrane proteins. In order to avoid these effects, we tested the Façade detergents as possible alternative rim-forming agents for small isotropic bicelles. In the present work we characterized the size of bicelles formed by 3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane (Façade-EM) and 3α-hydroxy-7α,12α-di-(((2-(trimethylamino)ethyl)phosphoryl)ethyloxy)-cholane Façade-EPC as a function of temperature and lipid/detergent ratio by 1H NMR diffusion spectroscopy. Additionally, the denaturing effects of these two rim-forming agents were investigated using the junction of the transmembrane and intracellular domains of the p75 neurotrophin receptor (p75NTR) as a model object. We show that the use of Façades allows decreasing the temperature-dependent growth of bicelles. The ability of Façade-EM-based bicelles to support the native structure and soluble state of the p75NTR intracellular domain was also revealed.
Constructing Quasi-Periodic Wave Solutions of Differential-Difference Equation by Hirota Bilinear Method
Authors: Wang Qi 
Published: November 2016

Abstract
In the present paper, based on the Riemann theta function, the Hirota bilinear method is extended to directly construct a kind of quasi-periodic wave solution of a new integrable differential-difference equation. The asymptotic property of the quasi-periodic wave solution is analyzed in detail. It will be shown that quasi-periodic wave solution converge to the soliton solutions under certain conditions and small amplitude limit.
Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala
Authors: Basu Sreetama , Kustanovich Irina , Lamprecht Raphael 
Published: November 2016

AbstractThe actin cytoskeleton is involved in key neuronal functions such as synaptic transmission and morphogenesis. However, the roles and regulation of actin cytoskeleton in memory formation remain to be clarified. In this study, we unveil the mechanism whereby actin cytoskeleton is regulated to form memory by exploring the roles of the major actin-regulatory proteins Arp2/3, VASP, and formins in long-term memory formation. Inhibition of Arp2/3, involved in actin filament branching and neuronal morphogenesis, in lateral amygdala (LA) with the specific inhibitor CK-666 during fear conditioning impaired long-term, but not short-term, fear memory. The inactive isomer CK-689 had no effect on memory formation. We observed that Arp2/3 is colocalized with the actin-regulatory protein profilin in LA neurons of fear-conditioned rats. VASP binding to profilin is needed for profilin-mediated stabilization of actin cytoskeleton and dendritic spine morphology. Microinjection of poly-proline peptide [G(GP5)3] into LA, to interfere with VASP binding to profilin, impaired long-term but not short-term fear memory formation. Control peptide [G(GA5)3] had no effect. Inhibiting formins, which regulate linear actin elongation, in LA during fear conditioning by microinjecting the formin-specific inhibitor SMIFH2 into LA had no effect on long-term fear memory formation. We conclude that Arp2/3 and VASP, through the profilin binding site, are essential for the formation of long-term fear memory in LA and propose a model whereby these proteins subserve cellular events, leading to memory consolidation.
Understanding Unintended Consequences and Health Information Technology
Authors: Randell R. , Borycki E. M. , Kuziemsky C. E. 
Published: November 2016

SummaryObjective: No framework exists to identify and study unintended consequences (UICs) with a focus on organizational and social issues (OSIs). To address this shortcoming, we conducted a literature review to develop a framework for considering UICs and health information technology (HIT) from the perspective of OSIs.Methods: A literature review was conducted for the period 2000-2015 using the search terms “unintended consequences” and “health information technology”. 67 papers were screened, of which 18 met inclusion criteria. Data extraction was focused on the types of technologies studied, types of UICs identified, and methods of data collection and analysis used. A thematic analysis was used to identify themes related to UICs.Results: We identified two overarching themes. One was the definition and terminology of how people classify and discuss UICs. Second was OSIs and UICs. For the OSI theme, we also identified four sub-themes: process change and evolution, individual-collaborative interchange, context of use, and approaches to model, study, and understand UICs.Conclusions: While there is a wide body of research on UICs, there is a lack of overall consensus on how they should be classified and reported, limiting our ability to understand the implications of UICs and how to manage them. More mixed-methods research and better proactive identification of UICs remain priorities. Our findings and framework of OSI considerations for studying UICs and HIT extend existing work on HIT and UICs by focusing on organizational and social issues.