bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated geological quality evaluation using advanced wireline logs and core data: a case study on high clay shale oil reservoir in China
Authors: Zhang Zhaoqian , Song Yanjie , Yan Weilin , Yin Shujun , Zheng Jiandong , Li Chuang 
Published: September 2024

AbstractIn the unconventional energy sector, shale oil is increasingly recognized as a crucial supplement to production. In recent years, China has made significant advancements in the development of shale oil. A unique type of pure shale reservoir in the Songliao Basin, distinct from established shale oil reservoirs worldwide, has emerged as a focal point for exploration and research endeavors. This kind of shale exhibits enhanced heterogeneity, high clay content, intricate rock electricity relationship, posing significant challenges to formation evaluation. This study introduces conversion coefficients for the elements and minerals, a decision tree model, a variable T2 cutoff value method, and 2D NMR cluster analysis, all based on the integration of microimaging, spectroscopy, and 2D NMR logging. These novel approaches facilitate a comprehensive geological quality evaluation of key parameters, including mineral composition, lithology, effective porosity, total organic carbon content, fluid composition, and saturation characteristics within pure shale formations from the Songliao Basin. The established petrophysical model has been validated by core analysis data and successfully applied in exploration wells. Through systematic petrophysical analysis, the optimal landing point for horizontal wells was identified based on the identification of the best reservoir quality interval with high movable oil and oil saturation. The subsequent drilling of horizontal wells demonstrated the reliability of petrophysical evaluation in terms of oil production. This integrated evaluation method for pure shale holds reference significance for similar shale reservoirs in other blocks in the future.
HDAC2-miR183-5p epigenetic circuit contributes to the growth of Philadelphia chromosome–positive B cell acute lymphoblastic leukemia via PTEN/AKT and c-MYC signaling pathway
Authors: Ding Yangyang , Feng Xiangjiang , Liu Zelin , Liao Ya , Pu Lianfang , Liu Jun , Wang Huiping , Zhai Zhimin , Xiong Shudao 
Published: September 2024

Abstract
Philadelphia chromosome-positive B cell acute lymphoblastic leukemia [Ph(+) B-ALL] is a hematological malignancy with a poor prognosis. Epigenetic abnormalities, especially abnormal histone acetylation and microRNA (miRNA) dysregulation, are a group of epigenetic patterns that contribute to leukemia progression. However, their regulatory mechanisms in Ph(+) B-ALL have not been fully elucidated. In this study, we identified that miR-183-5p is significantly downregulated in Ph(+) B-ALL and associated with poor prognosis. Moreover, we found that the BCR-ABL fusion gene is a key target gene of miR-183-5p. MiR-183-5p directly targets the BCR-ABL gene and induces cell apoptosis via PTEN/AKT and c-MYC signaling pathways. In addition, a histone deacetylase inhibitor could mitigate the suppressive effects of HDAC2 on miR-183-5p by promoting promoter acetylation, thereby enhancing cell apoptosis. In conclusion, our results indicate that miR-183-5p is a potential biomarker and suggest that a novel HDAC2-miR-183-5p epigenetic circuitry regulation may be involved in the pathogenesis of Ph(+) B-ALL. Taken together, These findings provide new insights into the design of promising molecular-targeted drugs for Ph(+) B-ALL.
SMP30 alleviates cerebral ischemia/reperfusion-induced neuronal injury by inhibiting HDAC4/PSD-95 to preserve mitochondrial function
Authors: Chen Rundong , Qian Lei , Zhang Qian , Qin Jiajun , Chen Xianzhen , Xu Xiaolong 
Published: September 2024

Abstract
Ischemic stroke is a major cause of global death and permanent disability. Major consequences of ischemic stroke include neuronal mitochondrial dysfunction. We investigated the effects of senescence marker protein 30 (SMP30) on mitochondria-mediated apoptosis and histone deacetylase 4 (HDAC4)/postsynaptic density-95 (PSD-95) signaling in stroke models in vivo and in vitro. Rats with middle cerebral artery occlusion/reperfusion (MCAO/R) were used to simulate cerebral ischemia/reperfusion (I/R) injury. SMP30 was downregulated in the brain tissues of rats after I/R induction. SMP30 overexpression decreased MCAO/R-induced infarct volumes and improved neurologic function and histopathological changes. Increasing SMP30 expression suppressed neuronal apoptosis and reduced mitochondrial dysfunction. SMP30 overexpression in SH-SY5Y and PC12 cells treated with oxygen-glucose deprivation/reoxygenation (OGD/R) decreased HDAC4 and PSD-95 expression; PSD-95 could bind to HDAC4. Furthermore, HDAC4 upregulation abolished the effects of SMP30 overexpression on OGD/R-induced apoptosis and mitochondrial dysfunction in SH-SY5Y cells. Together, these findings indicate that SMP30 alleviates cerebral I/R-induced neuronal injury by inhibiting HDAC4/PSD-95 to preserve mitochondrial function. These interactions might provide new treatment methods for patients with ischemic stroke.
Dissipated correction map method with trapezoidal rule for the simulations of gravitational waves from spinning compact binary
Authors: Luo Junjie , Zhang Hong-Hao , Lin Weipeng 
Published: September 2024

ABSTRACT
The correction map method means extended phase-space algorithm with correction map. In our research, we have developed a correction map method, specifically the dissipated correction map method with trapezoidal rule, for numerical simulations of gravitational waves from spinning compact binary systems. This new correction map method, denoted as $CM3$, has shown remarkable performance in various simulation results, such as phase-space distance, dissipated energy error, and gravitational waveform, closely resembling the high-order precision implicit Gaussian algorithm. When compared with the previously used mid-point map which is denoted as $C_2$, the $CM3$ consistently exhibits a closer alignment with the highly accurate Gaussian algorithm in waveform evolution and orbital trajectory analysis. Through detailed comparisons and analyses, it is evident that $CM3$ outperforms other algorithms, including $CM2$ and $C_2$ mentioned in this paper, in terms of accuracy and precision in simulating spinning compact binary systems. The incorporation of the trapezoidal rule and the optimization with a scale factor $\gamma$ have significantly enhanced the performance of $CM3$, making it a promising method for future numerical simulations in astrophysics. With the groundbreaking detection of gravitational waves by the LIGO/VIRGO collaboration, interest in this research domain has soared. Our work contributes valuable insights for the application of matched filtering techniques in the analysis of gravitational wave signals, enhancing the precision and reliability of these detection.
Impact of the high-speed solar wind stream over the low-latitude ionospheric system – a study combining Indian MOM and InSWIM observations
Authors: Jain Richa N , Choudhary R K , Ambili K M , Roopa M V , Dai Bijoy K 
Published: September 2024

ABSTRACT
In this study, we map the origin, acceleration, and propagation of the high-speed solar wind streams (HSS) and observe their impact on the low-latitude Earth’s ionosphere. Data from radio-sounding experiments conducted by the Indian Mars Orbiter Mission (MOM) from 2015 May 9–19 is analysed to understand the solar wind speed’s evolution at various helio-centric distances. The slope of the turbulence spectrum from 25 to 35 Rs was in the range of 0.2–0.4, indicative of the underdeveloped turbulence corresponding to the high-flow streams. It coincided with the appearance of the earth-facing coronal holes as observed in the coronal EUV images. The particle bulk velocity at L1 showed that the speeds began to rise from 400 km s−1 on May 11th–12th, reaching a peak of around 800 km s−1 on May13th–14th, followed by a gradual decrease to the average slow speeds. Geomagnetic disturbances during the same period manifested as a dip in the DST index values. The GNSS (Global Navigation Satellite System) data from the InSWIM (Indian network for Space Weather Impact Monitoring) network show an appreciable increase in the VTEC (vertical total electron content) of the ionosphere on disturbed days in entire low-latitude ionospheric region in the Indian sector. All these observed parameters correlate well with the HSS arrival. This is a unique study that connects the propagation of the HSS and its impact on near-Earth’s environment from the different vantage points in interplanetary space and proposes the application of Radio beacons to improve space weather forecasting.
Void number counts as a cosmological probe for the large-scale structure
Authors: Song Yingxiao , Xiong Qi , Gong Yan , Deng Furen , Chan Kwan Chuen , Chen Xuelei , Guo Qi , Liu Yun , Pei Wenxiang 
Published: September 2024

ABSTRACT
Void number count (VNC) indicates the number of low-density regions in the large-scale structure (LSS) of the Universe, and we propose to use it as an effective cosmological probe. By generating the galaxy mock catalogue based on Jiutian simulations and considering the spectroscopic survey strategy and instrumental design of the China Space Station Telescope (CSST), which can reach a magnitude limit $\sim$23 AB mag and spectral resolution $R\gtrsim 200$ with a sky coverage of 17 500 deg2, we identify voids using the watershed algorithm without any assumption of void shape and obtain the mock void catalogue and data of the VNC in six redshift bins from $z=0.3$ to 1.3. We use the Markov chain Monte Carlo method to constrain the cosmological and VNC parameters. The void linear underdensity threshold $\delta _{\rm v}$ in the theoretical model is set to be a free parameter at a given redshift to fit the VNC data and explore their redshift evolution. We find that the VNC can correctly derive the cosmological information, and the constraint strength on the cosmological parameters is comparable to that from the void size function method, which can reach a few per cent level in the CSST full spectroscopic survey. This is because, since the VNC is not sensitive to void shape, the modified theoretical model can match the data better by integrating over void features, and more voids could be included in the VNC analysis by applying simpler selection criteria, which will improve the statistical significance. It indicates that the VNC can be an effective cosmological probe for exploring the LSS.
Orbital architectures of planet-hosting binaries – III. Testing mutual inclinations of stellar and planetary orbits in triple-star systems
Authors: Evans Elise L , Dupuy Trent J , Sullivan Kendall , Kraus Adam L , Huber Daniel , Ireland Michael J , Ansdell Megan , Kuruwita Rajika L , Martinez Raquel A , Wood Mackenna L 
Published: September 2024

ABSTRACT
Transiting planets in multiple-star systems, especially high-order multiples, make up a small fraction of the known planet population but provide unique opportunities to study the environments in which planets would have formed. Planet-hosting binaries have been shown to have an abundance of systems in which the stellar orbit aligns with the orbit of the transiting planet, which could give insights into the planet formation process in such systems. We investigate here if this trend of alignment extends to planet-hosting triple-star systems. We present long-term astrometric monitoring of a novel sample of triple-star systems that host Kepler transiting planets. We measured orbit arcs in 21 systems, including 12 newly identified triples, from a homogeneous analysis of our Keck adaptive optics data and, for some systems, Gaia astrometry. We examine the orbital alignment within the nine most compact systems ($\lesssim 500$ au), testing if either (or both) of the stellar orbits align with the edge-on orbits of their transiting planets. Our statistical sample of triple systems shows a tendency toward alignment, especially when assessing the alignment probability using stellar orbital inclinations computed from full orbital fits, but is formally consistent with isotropic orbits. Two-population tests where half of the stellar orbits are described by a planet-hosting-binary-like moderately aligned distribution give the best match when the other half (non-planet-hosting) has a Kozai-like misaligned distribution. Overall, our results suggest that our sample of triple-star planet-hosting systems are not fully coplanar systems and have at most one plane of alignment.
The origin of the H α line profiles in simulated disc galaxies
Authors: Ejdetjärn Timmy , Agertz Oscar , Östlin Göran , Rey Martin P , Renaud Florent 
Published: September 2024

ABSTRACT
Observations of ionized H $\alpha$ gas in high-redshift disc galaxies have ubiquitously found significant line broadening, $\sigma _{\rm H\,\alpha }\sim 10{\!-\!}100\, {\rm km\, s^{-1}}$. To understand whether this broadening reflects gas turbulence within the interstellar medium (ISM) of galactic discs, or arises from out-of-plane emission in mass-loaded outflows, we perform radiation hydrodynamic simulations of isolated Milky Way-mass disc galaxies in a gas-poor (low-redshift) and gas rich (high-redshift) condition and create mock H $\alpha$ emission line profiles. We find that the majority of the total (integrated) ${\rm H\,\alpha }$ emission is confined within the ISM, with extraplanar gas contributing ${\sim} 45~{{\ \rm per\ cent}}$ of the extended profile wings ($v_z\ge 200$${\, \rm {km\, s^{-1}} }$) in the gas-rich galaxy. This substantiates using the ${\rm H\,\alpha }$ emission line as a tracer of mid-plane disc dynamics. We investigate the relative contribution of diffuse and dense ${\rm H\,\alpha }$ emitting gas, corresponding to diffuse ionized gas (DIG; $\rho \lesssim 0.1\, {\rm cm^{-3}}$, $T\sim 8\, 000$ K) and H ii regions ($\rho \gtrsim 10\, {\rm cm^{-3}}$, $T\sim 10\, 000$ K), respectively, and find that DIG contributes $f_{\rm DIG}\lesssim 10~{{\ \rm per\ cent}}$ of the total L$_{\rm H\alpha }$. However, the DIG can reach upwards of $\sigma _{\rm H\,\alpha } \sim 60{\!-\!}80\, {\rm km\, s^{-1}}$ while the H ii regions are much less turbulent $\sigma _{\rm H\,\alpha }\sim 10{\!-\!}40\, {\rm km\, s^{-1}}$. This implies that the $\sigma _{\rm H\,\alpha }$ observed using the full ${\rm H\,\alpha }$ emission line is dependent on the relative ${\rm H\,\alpha }$ contribution from DIG/H ii regions and a larger $f_{\rm DIG}$ would shift $\sigma _{\rm H\,\alpha }$ to higher values. Finally, we show that $\sigma _{\rm H\,\alpha }$ evolves, in both the DIG and H ii regions, with the galaxy gas fraction. Our high-redshift equivalent galaxy is roughly twice as turbulent, except for in the DIG which has a more shallow evolution.
Modeling the Determinants of Subjective Well-Being in Schizophrenia
Authors: Jeong Jae Hoon , Kim Jayoun , Kang Nuree , Ahn Yong Min , Kim Yong Sik , Lee Donghwan , Kim Se Hyun 
Published: September 2024

AbstractBackgroundThe ultimate goal of successful schizophrenia treatment is not just to alleviate psychotic symptoms, but also to reduce distress and achieve subjective well-being (SWB). We aimed to identify the determinants of SWB and their interrelationships in schizophrenia.MethodsData were obtained from 637 patients with schizophrenia enrolled in multicenter, open-label, non-comparative clinical trials. The SWB under the Neuroleptic Treatment Scale (SWN) was utilized; a cut-off score of 80 indicated a high level of SWB at baseline and 6 months. Various machine learning (ML) algorithms were employed to identify the determinants of SWB. Furthermore, network analysis and structural equation modeling (SEM) were conducted to explore detailed relationship patterns.ResultsThe random forest (RF) model had the highest area under the curve (AUC) of 0.794 at baseline. Obsessive-compulsive symptoms (OCS) had the most significant impact on high levels of SWB, followed by somatization, cognitive deficits, and depression. The network analysis demonstrated robust connections among the SWB, OCS, and somatization. SEM analysis revealed that OCS exerted the strongest direct effect on SWB, and also an indirect effect via the mediation of depression. Furthermore, the contribution of OCS at baseline to SWB was maintained 6 months later.ConclusionsOCS, somatization, cognition, and depression, rather than psychotic symptoms, exerted significant impacts on SWB in schizophrenia. Notably, OCS exhibited the most significant contribution not only to the current state of well-being but also to follow-up SWB, implying that OCS was predictive of SWB. The findings demonstrated that OCS management is critical for the treatment of schizophrenia.
Prompt matters: evaluation of large language model chatbot responses related to Peyronie’s disease
Authors: Warren Christopher J , Edmonds Victoria S , Payne Nicolette G , Voletti Sandeep , Wu Sarah Y , Colquitt JennaKay , Sadeghi-Nejad Hossein , Punjani Nahid 
Published: September 2024

Abstract

Introduction
Despite direct access to clinicians through the electronic health record, patients are increasingly turning to the internet for information related to their health, especially with sensitive urologic conditions such as Peyronie’s disease (PD). Large language model (LLM) chatbots are a form of artificial intelligence that rely on user prompts to mimic conversation, and they have shown remarkable capabilities. The conversational nature of these chatbots has the potential to answer patient questions related to PD; however, the accuracy, comprehensiveness, and readability of these LLMs related to PD remain unknown.

Aims
To assess the quality and readability of information generated from 4 LLMs with searches related to PD; to see if users could improve responses; and to assess the accuracy, completeness, and readability of responses to artificial preoperative patient questions sent through the electronic health record prior to undergoing PD surgery.

Methods
The National Institutes of Health’s frequently asked questions related to PD were entered into 4 LLMs, unprompted and prompted. The responses were evaluated for overall quality by the previously validated DISCERN questionnaire. Accuracy and completeness of LLM responses to 11 presurgical patient messages were evaluated with previously accepted Likert scales. All evaluations were performed by 3 independent reviewers in October 2023, and all reviews were repeated in April 2024. Descriptive statistics and analysis were performed.

Results
Without prompting, the quality of information was moderate across all LLMs but improved to high quality with prompting. LLMs were accurate and complete, with an average score of 5.5 of 6.0 (SD, 0.8) and 2.8 of 3.0 (SD, 0.4), respectively. The average Flesch-Kincaid reading level was grade 12.9 (SD, 2.1). Chatbots were unable to communicate at a grade 8 reading level when prompted, and their citations were appropriate only 42.5% of the time.

Conclusion
LLMs may become a valuable tool for patient education for PD, but they currently rely on clinical context and appropriate prompting by humans to be useful. Unfortunately, their prerequisite reading level remains higher than that of the average patient, and their citations cannot be trusted. However, given their increasing uptake and accessibility, patients and physicians should be educated on how to interact with these LLMs to elicit the most appropriate responses. In the future, LLMs may reduce burnout by helping physicians respond to patient messages.
Retrospective analysis of the efficacy of low-intensity extracorporeal shock wave therapy on young and middle-aged patients with erectile dysfunction responsive to PDE5Is: reducing the use of PDE5Is
Authors: Yao Rui-Jie , Wang Mao-Yuan , Chen Qiang , Xiao Hong , Yang Peng , Ding Yi-Lang , Chen Xi , Tang Song-Xi , Zhou Hui-Liang 
Published: September 2024

Abstract

Background
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a new method for treating erectile dysfunction (ED), but there are no standards yet for its indications.

Aim
The study aimed to suggest the early clinical efficacy of Li-ESWT and explore its related factors in young and middle-aged patients with ED who responded to phosphodiesterase type 5 Inhibitors (PDE5Is).

Methods
Data from 61 patients with ED who had previously responded to oral PDE5Is and subsequently underwent Li-ESWT were collected. This included information on age, body mass index, total testicular volume, sex hormones, as well as IIEF-EF scores before treatment and at 1, 3, and 6 months after treatment. The treatment regimen involves a weekly session for four consecutive weeks, with each session administering 5000 shock wave pulses. Linear regression analysis was utilized to identify factors associated with the efficacy of Li-ESWT treatment. Additionally, the improvement in different severity groups of ED before and after treatment, along with their IIEF-EF scores, was compared.

Outcomes
Li-ESWT was more targeted and effective for young and middle-aged patients with erectile dysfunction who responded to PDE5Is.

Results
The age of enrolled patients ranges from 22 to 53 years old, and the IIEF-EF scores at 1 month, 3 months, and 6 months after treatment were compared to baseline for efficacy assessment, showing significant improvements (P &lt; .0001) in all instances. Linear regression analysis using baseline data revealed predictive factors associated with treatment efficacy: treatment efficacy was negatively correlated with baseline IIEF-EF scores (t = −2.599, P = .013) and positively correlated with baseline LH levels (t = 2.170, P = .036).

Clinical Implications
Given the considerable cost of Li-ESWT treatment and the emphasis on treatment continuity, we hope to identify the most suitable candidates for Li-ESWT therapy, thereby optimizing its application.

Strengths and Limitations
Our findings provide a better solution for nonelderly ED patients who are responsive to PDE5Is. This study was limited by our sample size and follow-up time.

Conclusion
After 3 months of Li-ESWT, the IIEF-EF score gradually stabilizes and short-term maintenance of PDE5Is medication increases the responsiveness to shock wave therapy.
Pay talk in contemporary workplaces
Authors: Denice Patrick , Rosenfeld Jake , Sun Shengwei 
Published: September 2024

Abstract
Drawing on a unique survey of US workers with information about their employers’ policies on pay discussions and whether workers engage in such talk with their coworkers, we provide the most comprehensive investigation into pay talk in workplaces to date. Unlike existing treatments, we focus on core organizational and relational factors that influence whether workers talk about pay. We theorize pay talk as a challenge to managerial discretion, and we hypothesize that organizational attributes related to pay-setting influence workers’ willingness to discuss wages and salaries with colleagues. Managers, in turn, combat such challenges to their discretion by instituting pay secrecy rules. Particular relational factors within organizations are related to workers’ violations of these rules. Findings indicate that the likelihood of pay discussions varies by workplace pay secrecy rules, managerial relations within organizations, and, in certain model specifications, sector and career turning points. Among status characteristics, only age is associated with discussing pay, with younger workers significantly more likely to talk about pay and to violate organizational rules meant to suppress pay discussions.