bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain
Authors: Carballo I. , Rabuñal N. , Alvela L. , Pérez L.‐F. , Vidal C. , Alonso M. , Sopeña B. , Gude F. , Gonzalez‐Quintela A. 
Published: January 2017

AbstractImmunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunological factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commercial turbidimetric assay in 413 individuals (median age, 55 years; 45% males), randomly selected from the adult population of a Spanish municipality. Serum IgD concentrations displayed considerable variation in the population, ranging from undetectable (<6.7 mg/l) to 878 mg/l. Serum IgD concentrations were undetectable in 78 cases (18.9%) and >100 mg/l in 39 cases (9.4%). Median IgD was 21.9 mg/l. Serum IgD concentrations were negatively associated with age and positively associated with smoking, after adjustment for potential confounders. Overweight individuals showed lower concentrations of IgD than did normal‐weight individuals. Atopy (positivity of skin tests to aeroallergens) was not significantly associated with IgD concentrations, although non‐symptomatic atopics showed higher IgD concentrations. No consistent association was observed between serum IgD concentrations and gender, metabolic syndrome, or alcohol consumption. No significant association was found between baseline IgD concentrations and development of either allergic or immune disease after a median 11.4 years of follow‐up. In conclusion, serum IgD concentrations in adults show a wide variation in the population and may be influenced by common factors, particularly age and smoking habit. These factors should be taken into account when defining reference ranges for serum IgD concentrations.
‘Let the King Save the Poor’: The Discursive Mechanism Underlying the Under‐exercise of Social Rights in South Korea
Authors: Jung Yong Moon 
Published: January 2017

AbstractThis study was prompted by discrepancies observed between the quantitative expansion and the qualitative stalemate in social policy in South Korea. Despite a revamped social security system, changes in South Korean social policies have not led to significant coverage expansion or improved income and poverty distribution. The frequent appearance of the Korean proverb that ‘even the King cannot save the poor’ in policy participants' narratives reflects a lack of confidence in the Government's ability to address persistent social disadvantages and the prevalence of a fatalistic policy perspective. This proverb has a conceptual affinity with an individualistic approach and has effectively functioned as a governance tool to oppress the progress of welfare rights. This research shows that an expenditure‐based model could lead to actual policy situations being misrepresented. Further, institutional policy arrangements may not be a sufficient condition for improving policy performance. It is suggested that a rights‐based approach should be adopted for both theorization of the transition of the welfare regimes and discursive practice for a policy paradigm change.
Genome Sequence of Herpes Simplex Virus 1 Strain SC16
Authors: Rastrojo Alberto , López-Muñoz Alberto Domingo , Alcamí Antonio 
Published: January 2017

ABSTRACT

Herpes simplex virus 1 (HSV-1), also known as
Human herpesvirus 1
, is a highly prevalent human neurotropic pathogen that causes a variety of diseases, including lethal encephalitis. Here, we report the genome sequence of the HSV-1 strain SC16.
Draft Genome Sequence of
Coniochaeta ligniaria
NRRL 30616, a Lignocellulolytic Fungus for Bioabatement of Inhibitors in Plant Biomass Hydrolysates
Authors: Jiménez Diego Javier , Hector Ronald E. , Riley Robert , Lipzen Anna , Kuo Rita C. , Amirebrahimi Mojgan , Barry Kerrie W. , Grigoriev Igor V. , van Elsas Jan Dirk , Nichols Nancy N. 
Published: January 2017

ABSTRACT

Here, we report the first draft genome sequence (42.38 Mb containing 13,657 genes) of
Coniochaeta ligniaria
NRRL 30616, an ascomycete with biotechnological relevance in the bioenergy field given its high potential for bioabatement of toxic furanic compounds in plant biomass hydrolysates and its capacity to degrade lignocellulosic material.
Complete Genome Sequence of Lactococcus piscium CNCM I-4031, a Bioprotective Strain for Seafood Products
Authors: Marché Laurent , Saraoui Taous , Remenant Benoit , Zagorec Monique , Prévost Hervé , Delbarre-Ladrat Christine , Leroi Françoise , Pilet Marie France 
Published: January 2017

ABSTRACT

Lactococcus piscium
CNCM I-4031 is a psychotrophic foodborne lactic acid bacterium showing potential interest for the biopreservation of seafood products due to its inhibition properties toward pathogenic and spoilage bacteria. The analysis of its genome will provide a better understanding of the mechanisms of interaction between these bacteria.
Whole-Genome Sequence and Annotation of Salmonella enterica subsp.
enterica
Serovar Enteritidis Phage Type 8 Strain EN1660
Authors: Perry Benjamin J. , Fitzgerald Stephen F. , Kröger Carsten , Cameron Andrew D. S. 
Published: January 2017

ABSTRACT

The genome of
Salmonella enterica
subspecies
enterica
serovar Enteritidis phage type 8 strain EN1660, isolated from an outbreak in Thunder Bay, Canada, was sequenced to 46-fold coverage using an Illumina MiSeq with 300-bp paired-end sequencing chemistry to produce 28 contigs with an
N
50
value of 490,721 bp.
Draft Genome Sequence of Staphylococcus succinus subsp.
succinus
Type Strain DSM 14617, Isolated from Plant and Soil Inclusions within 25- to 35-Million-Year-Old Dominican Amber
Authors: Zhou Hairui , Yao Zhenyu , Shi Haihong , Wang Baixin , Li Dong , Hou Jie , Ma Shuxia 
Published: January 2017

ABSTRACT

Staphylococcus succinus
subsp.
succinus
type strain DSM 14617 was isolated from plant and soil inclusions within 25- to 35-million-year-old Dominican amber. The complete genome sequence of strain DSM 14617
T
includes a genome of 2.88 Mb (32.94% G+C content) without any plasmids.
Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment
Authors: Varn Frederick S. , Wang Yue , Mullins David W. , Fiering Steven , Cheng Chao 
Published: January 2017

Abstract
With the recent advent of immunotherapy, there is a critical need to understand immune cell interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts. Multidimensional datasets have enabled systematic approaches to dissect these interactions in large numbers of patients, furthering our understanding of the patient immune response to solid tumors. Using an integrated approach, we inferred the infiltration levels of distinct immune cell subsets in 23 tumor types from The Cancer Genome Atlas. From these quantities, we constructed a coinfiltration network, revealing interactions between cytolytic cells and myeloid cells in the tumor microenvironment. By integrating patient mutation data, we found that while mutation burden was associated with immune infiltration differences between distinct tumor types, additional factors likely explained differences between tumors originating from the same tissue. We concluded this analysis by examining the prognostic value of individual immune cell subsets as well as how coinfiltration of functionally discordant cell types associated with patient survival. In multiple tumor types, we found that the protective effect of CD8+ T cell infiltration was heavily modulated by coinfiltration of macrophages and other myeloid cell types, suggesting the involvement of myeloid-derived suppressor cells in tumor development. Our findings illustrate complex interactions between different immune cell types in the tumor microenvironment and indicate these interactions play meaningful roles in patient survival. These results demonstrate the importance of personalized immune response profiles when studying the factors underlying tumor immunogenicity and immunotherapy response. Cancer Res; 77(6); 1271–82. ©2017 AACR.
Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells
Authors: Hasanov Zulfiyya , Ruckdeschel Tina , König Courtney , Mogler Carolin , Kapel Stephanie S. , Korn Claudia , Spegg Carleen , Eichwald Viktoria , Wieland Matthias , Appak Sila , Augustin Hellmut G. 
Published: January 2017

Objective—
Vascular smooth muscle cells (VSMC) play a key role in the pathogenesis of atherosclerosis, the globally leading cause of death. The transmembrane orphan receptor endosialin (CD248) has been characterized as an activation marker of cells of the mesenchymal lineage including tumor-associated pericytes, stromal myofibroblasts, and activated VSMC. We, therefore, hypothesized that VSMC-expressed endosialin may display functional involvement in the pathogenesis of atherosclerosis.

Approach and Results—
Expression of endosialin was upregulated during atherosclerosis in apolipoprotein E (ApoE)–null mice and human atherosclerotic samples analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry. Atherosclerosis, assessed by Oil Red O staining of the descending aorta, was significantly reduced in ApoE/endosialin-deficient mice on Western-type diet. Marker analysis of VSMC in lesions induced by shear stress–modifying cast implantation around the right carotid artery identified a more pronounced contractile VSMC phenotype in the absence of endosialin. Moreover, in addition to contributing to neointima formation, endosialin also potentially regulated the proinflammatory phenotype of VSMC as evidenced in surrogate cornea pocket assay experiments in vivo and corresponding flow cytometry and ELISA analyses in vitro.

Conclusions—
The experiments identify endosialin as a potential regulator of phenotypic remodeling of VSMC contributing to atherosclerosis. The association of endosialin with atherosclerosis and its absent expression in nonatherosclerotic samples warrant further consideration of endosialin as a therapeutic target and biomarker.
Inferior Frontal Cortex Contributions to the Recognition of Spoken Words and Their Constituent Speech Sounds
Authors: Rogers Jack C. , Davis Matthew H. 
Published: January 2017

AbstractSpeech perception and comprehension are often challenged by the need to recognize speech sounds that are degraded or ambiguous. Here, we explore the cognitive and neural mechanisms involved in resolving ambiguity in the identity of speech sounds using syllables that contain ambiguous phonetic segments (e.g., intermediate sounds between /b/ and /g/ as in “blade” and “glade”). We used an audio-morphing procedure to create a large set of natural sounding minimal pairs that contain phonetically ambiguous onset or offset consonants (differing in place, manner, or voicing). These ambiguous segments occurred in different lexical contexts (i.e., in words or pseudowords, such as blade–glade or blem–glem) and in different phonological environments (i.e., with neighboring syllables that differed in lexical status, such as blouse–glouse). These stimuli allowed us to explore the impact of phonetic ambiguity on the speed and accuracy of lexical decision responses (Experiment 1), semantic categorization responses (Experiment 2), and the magnitude of BOLD fMRI responses during attentive comprehension (Experiment 3). For both behavioral and neural measures, observed effects of phonetic ambiguity were influenced by lexical context leading to slower responses and increased activity in the left inferior frontal gyrus for high-ambiguity syllables that distinguish pairs of words, but not for equivalent pseudowords. These findings suggest lexical involvement in the resolution of phonetic ambiguity. Implications for speech perception and the role of inferior frontal regions are discussed.
A Global Multilayer Cloud Identification with POLDER/PARASOL
Authors: Desmons M. , Ferlay N. , Parol F. , Riédi J. , Thieuleux F. 
Published: January 2017

AbstractThe detection of multilayer cloud situations is important for satellite retrieval algorithms and for many climate-related applications. In this paper, the authors describe an algorithm based on the exploitation of the Polarization and Directionality of the Earth’s Reflectance (POLDER) observations to identify monolayered and multilayered cloudy situations along with a confidence index. The authors’ reference comes from the synergy of the active instruments of the A-Train satellite constellation. The algorithm is based upon a decision tree that uses a metric from information theory and a series of tests on POLDER level-2 products. The authors obtain a multilayer flag as the final result of a tree classification, which takes discrete values between 0 and 100. Values closest to 0 (100) indicate a higher confidence in the monolayer (multilayer) character. This indicator can be used as it is or with a threshold level that minimizes the risk of misclassification, as a binary index to distinguish between monolayer and multilayer clouds. For almost fully covered and optically thick enough cloud scenes, the risk of misclassification ranges from 29% to 34% over the period 2006–10, and the average confidences in the estimated monolayer and multilayer characters of the cloud scenes are 74.0% and 58.2%, respectively. With the binary distinction, POLDER provides a climatology of the mono–multilayer cloud character that exhibits some interesting features. Comparisons with the performance of the Moderate Resolution Imaging Spectroradiometer (MODIS) multilayer flag are given.
Psychometric properties of the NOMO 1.0 tested among adult powered-mobility users
Authors: Sund Terje , Brandt Åse , Anttila Heidi , Iwarsson Susanne 
Published: January 2017

Background. The Nordic Mobility Related Outcome Evaluation of Assistive Device Intervention (NOMO 1.0) instrument evaluates the effectiveness of mobility devices in assessing mobility-related participation, captured by three scales (Need for Assistance, Frequency, and Ease/Difficulty) and one index (Participation Repertoire). Purpose. This study aimed to investigate a range of psychometric properties of the NOMO 1.0 in a sample of adult powered mobility device (PMD) users. Method. Data collected from PMD users ( N = 248) in Denmark, Finland, and Norway as part of a larger study were analyzed using state-of-the-art statistical methods. Findings. The acceptability and applicability of the NOMO 1.0 items were generally within recommended values. Some floor/ceiling effects were found and the reliability was acceptable for only the Frequency scale. The factor analysis identified one component for the Need for Assistance scale and six components of the Frequency scale. Implications. The NOMO 1.0 should be used for research purposes and not for clinical practice. Better reliability should be established for the Need for Assistance and Ease/Difficulty scales prior to further psychometric testing to establish the validity of the NOMO 1.0.
Software Export
Authors: Illiyan Asheref 
Published: January 2017

This paper analyses India s potential, performance, and problems in software export over the years. The results of the study show that software export has been growing con~istently at a higher rate of 50-60 per cent in the 1990s. Growing respect for Indian software industry in international market, continued rise in offshore services, entry into new markets. Y2K data conversion business and of course various steps taken by Government to promote export by simplifying procedures, tax concessions. by establishing software technology parks, and by initiating more liberal foreign investment policies, are considered to be the major factors that gave a fillip to the phenomenal growth of Indian software export. A close look at the destinations of the software export shows that USA continues to top the list followed by Europe, South East Asia, Japan and others. The study finds the important comparative advantage that India possesses over other countries are: worlds second largest pool of scientific manpower with English speaking skill, low cost of labour. investment friendly economic climate and policy, locational time difference with the Western world, etc. The major problems affecting Indian software export are: shortage of competent professionals. inadequate telecommunication facilities and other infrastructural bottelnecks, weak domestic market. etc. Some of the few suggestions that the present study makes are: reorienting and restructuring the educational systems in tune with the current needs of the economy, conducting a national level test in line with the engineering or medical entrance after 10+2 to draw the best talents to IT field, introduction of computers at school (Ind college levels, providing easy access to loans to IT students, providing high quality infrastructure and communication facilities , attraction of more private participation, both domestic and foreign in IT industry.
Gm(5) Grouping of Dried Bloodstains
Authors: Khalap S. , Divall G. B. 
Published: January 2017

An absorption—inhibition method for the detection of Gm(5) in dried bloodstains is described. This antigen compares very well with other blood group systems with regards to the amount of bloodstain required and its resistance to degradation. Particular reference is made to the association of Gm(5) with Gm(-1, −2). When a stain fails to inhibit anti-Gm(1) and anti-Gm(2), this may represent a true Gm(-1, −2) result, or that there was insufficient material to inhibit each antiserum. The detection of Gm(5) in a bloodstain extract provides an objective means of confirming the apparent absence of Gra(1) and Gm(2) as representing a true Gm(-1, −2) result.
HIV Screening Practices and Hospital Characteristics in the U.S., 2009–2010
Authors: Herrin Jeph , Wesolowski Laura G. , Heffelfinger James D. , Bostick Nathan , Hall H. Irene , Ethridge Steven F. , Branson Bernard M. 
Published: January 2017

Objectives. The Centers for Disease Control and Prevention recommends HIV screening in U.S. health-care settings unless providers document a yield of undiagnosed HIV infections of <1 per 1,000 population. However, implementation of this guidance has not been widespread and little is known of the characteristics of hospitals with screening practices in place We assessed how screening practices vary with hospital characteristics. Methods. We used a national hospital survey of HIV testing practices, linked to HIV prevalence for the county, parish, borough, or city where the hospital was located, to assess HIV screening of some or all patients by hospitals. We used multivariate logistic regression analysis to assess the association between screening practices and hospital characteristics that were significantly associated with screening in bivariate analyses. Results. Of 376 hospitals in areas of prevalence ≥0.1%, only 25 (6.6%) reported screening all patients for HIV and 131 (34.8%) reported screening some or all patients Among 638 hospitals included, screening some or all patients was significantly (p<0.05) more common at teaching hospitals, hospitals with higher numbers of annual admissions, and hospitals with a high proportion of Medicaid admissions. In multivariable analysis, screening some or all patients was independently associated with admitting more than 15% of Medicaid patients and receiving resources or reimbursement for screening tests. Conclusion. We found that few hospitals surveyed reported screening some or all patients, and failure to screen is common across all types of hospitals in all regions of the country. Expanded reimbursement for screening may increase compliance with the recommendations.
Partners in Immunization: 2010 Survey Examining Differences among H1N1 Vaccine Providers in Washington State
Authors: Seib Katherine , Gleason Cindy , Richards Jennifer L. , Chamberlain Allison , Andrews Tracey , Watson Lin , Whitney Ellen , Hinman Alan R. , Omer Saad B. 
Published: January 2017

Objectives. Emergency response involving mass vaccination requires the involvement of traditional vaccine providers as well as other health-care providers, including pharmacists, obstetricians, and health-care providers at correctional facilities We explored differences in provider experiences administering pandemic vaccine during a public health emergency. Methods. We conducted a cross-sectional survey of H1N1 vaccine providers in Washington State, examining topics regarding pandemic vaccine administration, participation in preparedness activities, and communication with public health agencies We also examined differences among provider types in responses received ( n=619, 80.9% response rate). Results. Compared with other types of vaccine providers (e.g., family practitioners, obstetricians, and specialists), pharmacists reported higher patient volumes as well as higher patient-to-practitioner ratios, indicating a broad capacity for community reach. Pharmacists and correctional health-care providers reported lower staff coverage with seasonal and H1N1 vaccines. Compared with other vaccine providers, pharmacists were also more likely to report relying on public health information from federal sources They were less likely to report relying on local health departments (LHDs) for pandemic-related information, but indicated a desire to be included in LHD communications and plans. While all provider types indicated a high willingness to respond to a public health emergency, pharmacists were less likely to have participated in training, actual emergency response, or surge capacity initiatives. No obstetricians reported participating in surge capacity initiatives. Conclusions. Results from this survey suggest that efforts to increase communication and interaction between public health agencies and pharmacy, obstetric, and correctional health-care vaccine providers may improve future preparedness and emergency response capability and reach.
Using GIS and Secondary Data to Target Diabetes-Related Public Health Efforts
Authors: Curtis Amy B. , Kothari Catherine , Paul Rajib , Connors Elyse 
Published: January 2017

Objectives. To efficiently help communities prevent and manage diabetes, health departments need to be able to target populations with high risk but low resources To aid in this process, we mapped county-level diabetes-related rates and resources/use using publicly available secondary data to identify Michigan counties with high diabetes prevalence and low or no medical and/or community resources. Methods. We collected county-level diabetes-related rates and resources from Web-based sources and mapped them using geographic information systems (GIS) software. Data included age-adjusted county diabetes rates, diabetes-related medical resource and resource use (i.e., the number of endocrinologists and percentage of Medicare patients with diabetes who received hemoglobin A1c testing in the past year), community resources (i.e., the number of certified diabetes self-management education and diabetes support groups), as well as population estimates and demographics (e.g., rural residence, education, poverty, and race/ethnicity). We created GIS maps highlighting areas that had higher-than-median rates of disease and lower-than-median resources. We also conducted linear, logistic, and Poisson regression analyses to confirm GIS findings. Results. There were clear regional trends in resource distribution across Michigan. The 15 counties in the Upper Peninsula were lacking in medical resources but higher in community resources compared with the 68 counties in the Lower Peninsula. There was little apparent association between need (diabetes prevalence) and diabetes-related resources/use. Specific counties with high diabetes prevalence and low resources were easily identified using GIS mapping. Conclusion. Using public data and mapping tools identified diabetes health-service shortage areas for targeted public health programming.