bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of a mosquito net voucher subsidy programme on incremental ownership: The case of the Tanzania National Voucher Scheme
Authors: Harman Luke , Goodman Catherine , Dorward Andrew 
Published: September 2017

AbstractThe subsidisation of mosquito nets has been widely used to increase ownership in countries where malaria represents a public health problem. However, an important question that has not been addressed empirically is how far net subsidy programmes increase ownership above the level that would have prevailed in the absence of the subsidy (i.e., incremental ownership). This study addresses that gap by investigating the impact of a large‐scale mosquito net voucher subsidy––the Tanzania National Voucher Scheme (TNVS)––on short‐term demand for unsubsidised commercial nets, estimating a household demand model with nationally representative household survey data. The results suggest that, despite the TNVS using a categorical targeting approach that did not discriminate by wealth, it still led to a large increase in incremental ownership of mosquito nets, with limited evidence of displacement of unsubsidised sales. Although no evidence is found of an additional TNVS voucher decreasing the number of unsubsidised sales in the same period, results indicate that an additional TNVS voucher reduced the probability of purchasing any unsubsidised net in the same period by 14%. The findings also highlight the critical role played by social learning or campaign messaging in increasing mosquito net ownership.
Rate of seeding with biopsies and ablations of hepatocellular carcinoma: A retrospective cohort study
Authors: Szpakowski Jean‐Luc , Drasin Todd E. , Lyon Liisa L. 
Published: September 2017

Biopsies of liver masses that prove to be hepatocellular carcinomas (HCCs) are associated with a risk of seeding the abdominal or chest wall with tumor cells. The reported frequency of seeding varies greatly in the literature. We performed a retrospective cohort study in a large integrated health care system to examine rates of seeding in patients with HCC who had targeted liver biopsies, ablations, or both performed by community radiologists. We reviewed pathology and radiology records to determine the occurrence of wall seeding, defined as a chest or abdominal wall lesion along a definite or probable needle tract. A total of 1,015 patients had targeted liver biopsies (795), ablations (72), or both (148). Multiple procedures were done in 284 patients (28%). Six cases of seeding were identified. The rate of wall seeding was 2/795 patients (0.13%; 95% confidence interval [CI], 0.00%‐0.60%) if only biopsies were done versus 4/220 (1.82%; 95% CI, 0.05%‐3.58%) if ablations were performed (P = 0.01). The rate was 0/72 (0.00%; 95% CI, 0.00%‐0.04%) with ablations alone and 4/148 (2.70%; 95% CI, 0.74%‐6.78%) if both procedures were done (P = 0.31). Of those with 1 year follow‐up (n = 441), the rate of seeding was 2/269 (0.74%; 95% CI, 0.00%‐1.77%) if biopsies alone were done and 4/172 (2.33%; 95% CI, 0.07%‐4.58%) if ablations were done. In none of the cases was the seeding a proximate cause of death. Conclusion: Biopsies of liver masses are associated with a low rate of wall seeding when performed in a community setting and when they are the sole procedures. Ablations may have a higher rate of seeding, particularly if done with biopsies, but are still rare. (Hepatology Communications 2017;1:841–851)
Missing binary data extraction challenges from Cochrane reviews in mental health and Campbell reviews with implications for empirical research
Authors: Spineli Loukia M. 
Published: September 2017

ObjectivesTο report challenges encountered during the extraction process from Cochrane reviews in mental health and Campbell reviews and to indicate their implications on the empirical performance of different methods to handle missingness.MethodsWe used a collection of meta‐analyses on binary outcomes collated from a previous work on missing outcome data. To evaluate the accuracy of their extraction, we developed specific criteria pertaining to the reporting of missing outcome data in systematic reviews. Using the most popular methods to handle missing binary outcome data, we investigated the implications of the accuracy of the extracted meta‐analysis on the random‐effects meta‐analysis results.ResultsOf 113 meta‐analyses from Cochrane reviews, 60 (53%) were judged as “unclearly” extracted (ie, no information on the outcome of completers but available information on how missing participants were handled) and 42 (37%) as “unacceptably” extracted (ie, no information on the outcome of completers as well as no information on how missing participants were handled). For the remaining meta‐analyses, it was judged that data were “acceptably” extracted (ie, information on the completers' outcome was provided for all trials). Overall, “unclear” extraction overestimated the magnitude of the summary odds ratio and the between‐study variance and additionally inflated the uncertainty of both meta‐analytical parameters. The only eligible Campbell review was judged as “unclear.”ConclusionsDepending on the extent of missingness, the reporting quality of the systematic reviews can greatly affect the accuracy of the extracted meta‐analyses and by extent, the empirical performance of different methods to handle missingness.
Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole‐mount histopathology as a reference standard
Authors: Starobinets Olga , Simko Jeffry P. , Kuchinsky Kyle , Kornak John , Carroll Peter R. , Greene Kirsten L. , Kurhanewicz John , Noworolski Susan M. 
Published: September 2017

The purpose of this study was to characterize prostate cancer (PCa) based on multiparametric MR (mpMR) measures derived from MRI, diffusion, spectroscopy, and dynamic contrast‐enhanced (DCE) MRI, and to validate mpMRI in detecting PCa and predicting PCa aggressiveness by correlating mpMRI findings with whole‐mount histopathology. Seventy‐eight men with untreated PCa received 3 T mpMR scans prior to radical prostatectomy. Cancerous regions were outlined, graded, and cancer amount estimated on whole‐mount histology. Regions of interest were manually drawn on T2‐weighted images based on histopathology. Logistic regression was used to identify optimal combinations of parameters for the peripheral zone and transition zone to separate: (i) benign from malignant tissues; (ii) Gleason score (GS) ≤3 + 3 disease from ≥GS3 + 4; and (iii) ≤ GS3 + 4 from ≥GS4 + 3 cancers. The performance of the models was assessed using repeated fourfold cross‐validation. Additionally, the performance of the logistic regression models created under the assumption that one or more modality has not been acquired was evaluated. Logistic regression models yielded areas under the curve (AUCs) of 1.0 and 0.99 when separating benign from malignant tissues in the peripheral zone and the transition zone, respectively. Within the peripheral zone, combining choline, maximal enhancement slope, apparent diffusion coefficient (ADC), and citrate measures for separating ≤GS3 + 3 from ≥GS3 + 4 PCa yielded AUC = 0.84. Combining creatine, choline, and washout slope yielded AUC = 0.81 for discriminating ≤GS3 + 4 from ≥GS4 + 3 disease. Within the transition zone, combining washout slope, ADC, and creatine yielded AUC = 0.93 for discriminating ≤GS3 + 3 and ≥GS3 + 4 cancers. When separating ≤GS3 + 4 from ≥GS4 + 3 PCa, combining choline and washout slope yielded AUC = 0.92. MpMRI provides excellent separation between benign tissues and PCa, and across PCa tissues of different aggressiveness. The final models prominently feature spectroscopy and DCE‐derived metrics, underlining their value within a comprehensive mpMRI examination.
Genetic heterogeneity of uncharacterized childhood autoimmune diseases with lymphoproliferation
Authors: Takagi Masatoshi , Hoshino Akihiro , Yoshida Kenichi , Ueno Hiroo , Imai Kohsuke , Piao Jinhua , Kanegane Hirokazu , Yamashita Motoi , Okano Tsubasa , Muramatsu Hideki , Okuno Yusuke , Shiraishi Yuichi , Chiba Kenichi , Tanaka Hiroko , Miyano Satoru , Ogawa Seishi , Hayashi Yasuhide , Kojima Seiji , Morio Tomohiro 
Published: September 2017

AbstractAutoimmune diseases in children are rare and can be difficult to diagnose. Single causative genes have been identified for some pediatric autoimmune diseases. Such orphan diseases may not be diagnosed properly due to the variability of patients' phenotypes. Guidelines for the diagnostic process need to be developed. Fifteen patients with uncharacterized childhood autoimmune diseases with lymphoproliferation that had negative testing for autoimmune lymphoproliferative syndrome were subjected to whole‐exome sequencing to identify genes associated with these conditions. Five causative genes, CTLA4, STAT3, TNFAIP3, IKZF1, and PSTPIP1, were identified. These genes should be considered as candidates for uncharacterized childhood autoimmune diseases with lymphoproliferation.
Synthesis and characterization of polymer linked copper(I) bis(N‐heterocyclic carbene) mechanocatalysts
Authors: Michael Philipp , Sheidaee Mehr Shima Khazraee , Binder Wolfgang H. 
Published: September 2017

ABSTRACTIn this paper, the synthesis and characterization of a series of latent polymeric bis(N‐heterocyclic carbene) (NHC) copper(I) complexes is reported, which can be activated for the copper(I)‐catalyzed azide/alkyne cycloaddition (CuAAC) via ultrasound. To prove the influence of chain length and nature of the polymer towards the activation, poly(isobutylene) (PIB), poly(styrene) (PS) and poly(tetrahydrofuran) (PTHF) are synthesized via living polymerization techniques (LCCP, ATRP, CROP) obtaining different chain lengths (from 2500 to 9000 g/mol), followed by quaternization with N‐methylimidazole, generating the corresponding N‐methylimidazolium‐telechelic polymers. The deprotonation of these macroligands via strong bases like sodium tert‐butoxide (NaOtBu) or potassium hexamethyldisilazide (KHMDS) yields the free N‐heterocyclic carbenes (NHCs), which are used to coordinate to tetrakis(acetonitrile)copper(I) hexafluorophosphate, forming the final polymer‐based mono‐ and bis(N‐methylimidazole‐2‐ylidene) copper(I)X complexes. The structural proof of these complexes is accomplished via 1H‐NMR spectroscopy, MALDI‐TOF‐MS and GPC‐techniques. The activation of the copper(I) biscarbene catalysts by ultrasound is studied by GPC, revealing the cleavage of one shielding NHC‐ligand. The initial catalytic latency and the via ultrasound introduced catalytic activation is successfully demonstrated monitoring a CuAAC “click” reaction of benzyl azide and phenylacetylene by in situ 1H‐NMR spectroscopy introducing thus “click” conversions up to 97%. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3893–3907
Fascin and esophageal squamous cell carcinoma
Authors: Cheng Yinwei , Xie Jianjun , Zeng Famin , Nie Pingjuan , Wu Bingli , Du Zepeng , Pan Feng , Wu Jianyi , Xie Lei , Zhang Pixian , Xu Xiu‐e , Liao Liandi , Xie Yangmin , Shen Jian , Wu Zhiyong , Peng Yuhui , Xu Yiwei , Xie Wenming , Wang Shaohong , Lin Xuanhao , Fu Junhui , Zheng Chunpeng , Tao Lihua , Fang Wangkai , Xu Liyan , Li Enmin 
Published: September 2017

AbstractIn a cancer prevalence survey, China was recognized to have a high incidence of esophageal cancer. Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer and accounts for the vast majority of cases every year. ESCC cases in China contribute toward nearly half of all new global cases each year. As one of the higher ESCC prevalence regions in China, the Chaoshan District of Guangdong Province is the only area on the Chinese coastline with such a distinguished profile. Our laboratory, which is located in the Chaoshan District, studies the biological function, molecular basis, regulation mechanisms, and clinical significance of abnormally expressed cellular cytoskeleton binding proteins in ESCC, such as ezrin, fascin, LCN2, LOXL2, and DSC2. In the present review, we summarized studies on fascin in ESCC reported by our laboratory and other laboratories around the world. In ESCC, fascin expression is highly upregulated at the mRNA and protein levels, and can serve as an early biomarker for tumor invasion and metastasis. Furthermore, fascin transcription is directly activated through Sp1 binding to its promoter; this process is enhanced through the phosphorylation of Sp1 by the epidermal grown factor‐activated Mitogen‐activated protein kinase (MAPK)/Extracellular signal‐regulated kinase (ERK) (MEK)‐ERK1/2 signaling pathway. Furthermore, the function of fascin is also regulated by post‐translational modifications. For instance, the phosphorylation of several amino acid residues of fascin inhibits ESCC cell behavior and filopodia formation. However, whether other types of fascin modifications exist remains unknown and requires further study.
Assessment of a knowledge‐based RapidPlan model for patients with postoperative cervical cancer
Authors: Ma Changsheng , Huang Fujing 
Published: September 2017

AbstractObjectiveTo show the feasibility of using a knowledge‐based RapidPlan model to generate new cervical intensity modulated radiation therapy (IMRT) plans.MethodsA database of 20 cervical IMRT treatment plans was assembled to create a knowledge‐based IMRT RapidPlan model. Another 19 clinical cases were selected to test the model. A comparison analysis of the difference in dose–volume histograms between the semiautomated treatment plans and the original treatment plans was carried out.ResultsOn average, the new knowledge‐based RapidPlans can achieve planning target volume coverage that is highly comparable with the original plan, within 1%, as evaluated for D98, D95, and D1. For the rectum, the mean and standard deviation of the dose percentage differences for D20, D30, and D50 were 3.79 ± 8.31%, 4.00 ± 9.87%, and 1.52 ± 10.89%, respectively. For the bladder, the mean and standard deviation of the dose percentage differences for D20, D30, and D50 were –2.43 ± 9.40%, –2.03 ± 10.17%, and –2.94 ± 12.30%, respectively. For the femoral heads, the mean and standard deviation of the dose percentage differences for the left and right were 3.15 ± 18.29% and –3.18 ± 13.79%, respectively.ConclusionWe showed a knowledge‐based IMRT plan model for cervical cancer that can generate clinically acceptable treatment plans of high quality. This semiautomated approach can improve the efficiency of the treatment planning process while ensuring that high‐quality plans are developed.
A Comparative Study on DNA Binding Properties of 2,10,16,24‐Tetrakis 4‐(4‐hydroxyphenyl)‐1‐phenylethyl) phenoxy)‐Substituted Co(II) and Mg(II) Phthalocyanine Compounds
Authors: Arslantas Ali , Agirtas Mehmet Salih 
Published: September 2017

AbstractIn this study, DNA binding properties of 2,10,16,24‐tetrakis4‐(4‐hydroxyphenyl)‐1‐phenylethyl)phenoxy)phthalocyaninato Co(II) and Mg(II) compounds were analyzed. CT‐DNA was used to determine DNA binding properties of Co(II) (4) and Mg(II) (5) phthalocyanine compounds. The DNA binding properties of compounds 4 and 5 were investigated using electronic absorption titration, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation study, electrophoresis and viscosity measurements in Tris‐buffer (pH 7.0). The results indicated that Co(II) and Mg(II) phthalocyanine compounds have strong affinity for CT‐DNA through intercalation.
Palladium‐Catalyzed Aerobic Oxidative Synthesis of 3‐Phenylquinoline with Azides and Aldehydes
Authors: Luo Xin‐Liang , Liu Xing‐Xing , Pu Jing‐Hong , Tian Wan‐Fa , Zhou Xiao‐Qiang , Wei Dai‐Dong , Huang Guo‐Sheng 
Published: September 2017

AbstractA new strategy for the synthesis of 3‐phenylquinoline through annulation of azides with aldehydes has been established. The transformation was accomplished by palladium‐catalyzed C−H functionalization and C−C bond cleavage to form two C−C bonds and one C−N bond in one‐pot manner. This reaction system has a relatively broad reaction scope, providing a facile pathway for the synthesis of 3‐phenyl‐quinoline.
Copper‐Exchanged Magnetic‐FAp: Surface Catalysis in Decarboxylative Coupling of α‐Oxocarboxylic Acids with Formamides
Authors: Mirfarjood Seyed‐Abdollah , Mamaghani Manouchehr , Sheykhan Mehdi 
Published: September 2017

AbstractAn unprecedented heterogeneous catalysis in the decarboxylative coupling of α‐oxocarboxylic acids is developed. A novel copper‐containing magnetic catalyst was synthesized by introducing copper into calcium fluorapatite encapsulated iron oxide. This catalyst led to the synthesis of α‐ketoamides with a promising TON exceeding 1200.
Squid Ink‐Assisted Fabricating MoS2 Nanosheets/Ultrafine Biocarbon Spheres Composites with an Enhanced Lithium Ion Storage Performance
Authors: Yang Rongrong , Wang Jifei , Liu Wei , Zhang Yuan , Wang Huanlei , Liu Shuang , Guo Yaqi , Chen Shougang 
Published: September 2017

AbstractA strategy of utilizing biomass in energy applications has been highly concerned due to their low cost, renewability and environmental friendly. In this work, as one of rare zero‐dimensional biomass, squid inks composed of numerous uniform nanospheres are employed as both template and carbon source to fabricate a novel MoS2/carbon sphere composites by a facile glucose‐containing hydrothermal method and heat treatment. Differing to the common vertical growth of MoS2 nanosheets on the surface of substrates, the growth of the ultrathin MoS2 nanosheets along the surface of biospheres can be noticed evidently, leading to a closer combination of MoS2 nanosheets and carbon spheres. The as‐obtained MoS2/carbon sphere composites are further coated by a carbon film derived from glucoses to form a novel hierarchical porous architecture, thus showing the better structural integrity of the electrode materials, the enhanced electrical conductivity and the quick transport of electrons and Li+ ions. As anode materials of lithium ion batteries, the composites exhibit the excellent reversible discharge capacity with 97% of its initial capacity after 100 cycles at 0.5 A/g and rate capability of 510 mAh/g even at 10 A/g. These results not only indicate that the obtained product is a promising anode material for advanced LIBs, but also provides a new strategy for rational utilization of biotemplates.
Patients’ Opinions on Genetic Counseling on the Increased Risk of Parkinson Disease among Gaucher Disease Carriers
Authors: Mulhern Maureen , Bier Louise , Alcalay Roy N. , Balwani Manisha 
Published: September 2017

AbstractGaucher disease (GD) is an autosomal recessive disease caused by GBA mutations that is especially common in the Ashkenazi Jewish (AJ) population. The link between GBA mutations and Parkinson disease (PD), a later‐onset neurodegenerative condition, is well established, and studies have shown that GBA carriers have an increased lifetime risk of developing PD. Carrier screening for GD is frequently offered to couples during or prior to pregnancy, especially to those of AJ descent. However, no studies have been performed to assess if prospective parents would want to learn about their risk of developing PD incidentally through carrier screening. It is also unknown if pre‐test counseling on this topic would affect screening uptake. In order to answer these questions, a survey was administered to individuals who screened negative for GBA mutations. Of the 75 participants, 86.7% believed that patients should be informed about the increased risk of PD prior to having GD carrier screening, and 93.3% responded that this information would not have changed their decision to have carrier screening. These results indicate that healthcare providers should take into consideration patient preferences when determining how to counsel about GD carrier screening. Additionally, these results have implications for genetic counseling about other later‐onset conditions that may be incidentally ascertained through carrier screening.
Do new trainees pose a threat to the functional outcome of total knee arthroplasty? – The ‘January/July’ effect in a developing South Asian country: A retrospective cohort study
Authors: Malik Azeem Tariq , Ali Arif , Mufarrih Syed Hamza , Noordin Shahryar 
Published: September 2017

Abstract

Introduction
Previous studies have shown that the introduction of new trainees/residents results in an increased morbidity and mortality for the hospital. With differences in induction times of residents across the world and majority of research coming from the US, we aim at studying whether the introduction of new orthopedic residents/trainees bode ill for patients undergoing a total knee arthroplasty (TKA) in a developing country.

Materials & Methods
Single center retrospective cohort study done from 2006 to 2015. Induction of new residents in Pakistan happens at the start of the year (January). A total of 673 patients who underwent a unilateral or bilateral TKA where included in study. Surgeries were divided into 4 quarters of the year and comparison was carried out between them. Binomial logistic regression analysis was also carried out for significant variables.

Results
Surgeries done during the first quarter (Jan–March) was not associated with a longer length of stay (LOS) [p = 0.651], a longer total operative time (TOT)[p = 0.471], a higher drop in hemoglobin (Hb)[p = 0.146] and postoperative complications. Surgeries done during the first quarter of the year are a significant independent predictor of postoperative cardiac complications [p = 0.02].

Conclusion
Based on our study, we found no evidence to support a hypothesis of new trainees/residents bringing about an increased intraoperative and postoperative morbidity. Further large multicenter database studies are required from the South Asian region to further study this effect.

Highlights
Clinical, Magnetic Resonance Imaging, and Arthroscopic Correlation in Anterior Cruciate Ligament and Meniscal Injuries of the Knee
Authors: Ishani Patel , Vijay Chandru , Supreeth Nekkanti , Ravishankar Renukarya , Vardhan Reddy Vishnu , Vanaja Gopalakrishna Sampathirao 
Published: September 2017

Background The aim of this study is to compare and correlate the clinical, magnetic resonance imaging (MRI), and arthroscopy findings in anterior cruciate ligament (ACL) and meniscal injuries of the knee. Methods This was a prospective study of 30 cases of ACL and meniscal injuries of the knee admitted between September 2014 and May 2016, who underwent clinical examination, MRI, and arthroscopy of the knee. Results In our study of 30 cases, there were 26 male and four female patients with age ranging from 18 years to 60 years, with most patients in between 21 years and 30 years. Clinical examination had sensitivity of 90.91%, specificity of 100%, and accuracy of 93.33% for ACL, sensitivity of 83.33%, specificity of 77.78%, and accuracy of 80% for medial meniscus, and sensitivity of 75%, specificity of 77.27%, and accuracy of 76.67% for lateral meniscus. MRI had sensitivity of 95.45%, specificity of 87.5%, and accuracy of 93.33% for ACL, sensitivity of 91.67%, specificity of 55.56%, and accuracy of 70% for medial meniscus, and sensitivity of 62.5%, specificity of 72.73%, and accuracy of 70% for lateral meniscus. Conclusion In conclusion, the present study supports that clinical diagnosis is of primary necessity, as the positive predictive value is high for all the lesions. MRI is an additional diagnosing tool for ligament and meniscal injuries of the knee. Routine use of MRI to confirm the diagnosis is not indicated, as the positive predictive value is low, but can be used to exclude pathology, as the negative predictive value is high for all the lesions.