bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phototaxic Behavior of Subyearling Salmonids in the Nearshore Area of Two Urban Lakes in Western Washington State
Authors: Tabor Roger A. , Bell Alex T. C. , Lantz Daniel W. , Gregersen Chris N. , Berge Hans B. , Hawkins Denise K. 
Published: May 2017

AbstractWe conducted field experiments in the nearshore area of two urban lakes (Lake Washington and Lake Sammamish) in western Washington to test the attractive quality of artificial nighttime lighting to subyearling salmonids Oncorhynchus spp. In both lakes, experimental trials were conducted along a uniform 156‐m shoreline section twice a month (one night with lights and one control night without lights) from March to May to correspond with peak nearshore rearing of subyearling salmonids. We examined the effects of three light intensities on nearshore fish abundance: (1) no light, (2) dim light (maximum, 5.0 lx), and (3) bright light (maximum, 50.0 lx). These were compared with abundances from control nights without light treatments. Beach seining was used to determine fish abundance. For each month, the total number of subyearling salmonids (Chinook Salmon O. tshawytscha, Coho Salmon O. kisutch, and Sockeye Salmon O. nerka combined) was greater on the lighted nights (all treatments combined) than it was on the control nights. In both lakes, the most subyearling salmonids were collected in the bright‐light treatments, an intermediate amount in the dim‐light treatments, and few in the no‐light treatments. In some instances, subyearling salmonid abundances in the bright‐light treatments were more than 10 times greater than in the no‐light treatments. The effect of nighttime artificial lighting was generally more pronounced in March than in April or May. The results support our hypothesis that subyearling salmonids exhibit nocturnal phototaxic behavior when exposed to elevated nighttime lighting. A major concern of artificial nighttime lighting for subyearling salmonids is the potential for an increased predation risk, and we believe the prudent management goal would be to minimize artificial nighttime lighting.Received October 23, 2016; accepted March 7, 2017 Published online May 26, 2017
A novel community driven software for functional enrichment analysis of extracellular vesicles data
Authors: Pathan Mohashin , Keerthikumar Shivakumar , Chisanga David , Alessandro Riccardo , Ang Ching‐Seng , Askenase Philip , Batagov Arsen O. , Benito‐Martin Alberto , Camussi Giovanni , Clayton Aled , Collino Federica , Di Vizio Dolores , Falcon‐Perez Juan Manuel , Fonseca Pedro , Fonseka Pamali , Fontana Simona , Gho Yong Song , Hendrix An , Hoen Esther Nolte‐'t , Iraci Nunzio , Kastaniegaard Kenneth , Kislinger Thomas , Kowal Joanna , Kurochkin Igor V. , Leonardi Tommaso , Liang Yaxuan , Llorente Alicia , Lunavat Taral R. , Maji Sayantan , Monteleone Francesca , Øverbye Anders , Panaretakis Theocharis , Patel Tushar , Peinado Héctor , Pluchino Stefano , Principe Simona , Ronquist Goran , Royo Felix , Sahoo Susmita , Spinelli Cristiana , Stensballe Allan , Théry Clotilde , van Herwijnen Martijn J.C. , Wauben Marca , Welton Joanne L. , Zhao Kening , Mathivanan Suresh 
Published: May 2017

ABSTRACTBioinformatics tools are imperative for the in depth analysis of heterogeneous high‐throughput data. Most of the software tools are developed by specific laboratories or groups or companies wherein they are designed to perform the required analysis for the group. However, such software tools may fail to capture “what the community needs in a tool”. Here, we describe a novel community‐driven approach to build a comprehensive functional enrichment analysis tool. Using the existing FunRich tool as a template, we invited researchers to request additional features and/or changes. Remarkably, with the enthusiastic participation of the community, we were able to implement 90% of the requested features. FunRich enables plugin for extracellular vesicles wherein users can download and analyse data from Vesiclepedia database. By involving researchers early through community needs software development, we believe that comprehensive analysis tools can be developed in various scientific disciplines.
Chiral ligands designed in China
Authors: Liu Yuanyuan , Li Wenbo , Zhang Junliang 
Published: May 2017

Abstract
Asymmetric catalysis has become an indispensable and productive field within the Chinese organic chemistry society. The design of chiral ligands is one of the most prominent research areas in this field. Since the late 1990s, Chinese organic chemists have developed numerous chiral ligands possessing novel chiral skeletons and design concepts. Some of these ligands have been widely adopted and can be regarded as ‘privileged ligand’, which have shown excellent performance in many asymmetric catalytic reactions. In this review, we provide an overview of the chiral ligands designed by Chinese scientists with the aim of promoting the development of this area in China and with the hope of encouraging more scientists across the world to use these ligands when designing asymmetric reactions.
Testing Familial Transmission of Smoking With Two Different Research Designs
Authors: Treur Jorien L , Verweij Karin J H , Abdellaoui Abdel , Fedko Iryna O , de Zeeuw Eveline L , Ehli Erik A , Davies Gareth E , Hottenga Jouke-Jan , Willemsen Gonneke , Boomsma Dorret I , Vink Jacqueline M 
Published: May 2017

Abstract

Introduction
Classical twin studies show that smoking is heritable. To determine if shared family environment plays a role in addition to genetic factors, and if they interact (G×E), we use a children-of-twins design. In a second sample, we measure genetic influence with polygenic risk scores (PRS) and environmental influence with a question on exposure to smoking during childhood.

Methods
Data on smoking initiation were available for 723 children of 712 twins from the Netherlands Twin Register (64.9% female, median birth year 1985). Children were grouped in ascending order of risk, based on smoking status and zygosity of their twin-parent and his/her co-twin: never smoking twin-parent with a never smoking co-twin; never smoking twin-parent with a smoking dizygotic co-twin; never smoking twin-parent with a smoking monozygotic co-twin; and smoking twin-parent with a smoking or never smoking co-twin. For 4072 participants from the Netherlands Twin Register (67.3% female, median birth year 1973), PRS for smoking were computed and smoking initiation, smoking heaviness, and exposure to smoking during childhood were available.

Results
Patterns of smoking initiation in the four group children-of-twins design suggested shared familial influences in addition to genetic factors. PRS for ever smoking were associated with smoking initiation in all individuals. PRS for smoking heaviness were associated with smoking heaviness in individuals exposed to smoking during childhood, but not in non-exposed individuals.

Conclusions
Shared family environment influences smoking, over and above genetic factors. Genetic risk of smoking heaviness was only important for individuals exposed to smoking during childhood, versus those not exposed (G×E).

Implications
This study adds to the very few existing children-of-twins (CoT) studies on smoking and combines a CoT design with a second research design that utilizes polygenic risk scores and data on exposure to smoking during childhood. The results show that shared family environment affects smoking behavior over and above genetic factors. There was also evidence for gene–environment interaction (G×E) such that genetic risk of heavy versus light smoking was only important for individuals who were also exposed to (second-hand) smoking during childhood. Together, these findings give additional incentive to recommending parents not to expose their children to cigarette smoking.
The Benefits of Forced Experimentation: Striking Evidence from the London Underground Network*
Authors: Larcom Shaun , Rauch Ferdinand , Willems Tim 
Published: May 2017

AbstractWe present evidence that a significant fraction of commuters on the London Underground do not travel on their optimal route. We show that a strike on the Underground, which forced many commuters to experiment with new routes, brought lasting changes in behavior. This effect is stronger for commuters who live in areas where the Underground map is more distorted, which points to the importance of informational imperfections. Information resulting from the strike improved network efficiency. Search costs alone are unlikely to explain the suboptimal behavior.
Distal Junctional Failure Following Pediatric Spinal Fusion
Authors: Floccari Lorena V. , Su Alvin W. , McIntosh Amy L. , Rathjen Karl , Shaughnessy William J. , Larson A. Noelle 
Published: May 2017

Background:
Adjacent segment pathology is a known complication after spinal fusion, but little has been reported on junctional failure. A series of adolescent patients presented with acute distal junctional failure (DJF). We sought to determine any common features of these patients to develop a prevention strategy.

Methods:
A retrospective review was conducted of pediatric patients who developed DJF after instrumented spinal fusion performed at 2 institutions from 1999 to 2013. Patients with proximal junctional failure or junctional kyphosis without failure were excluded.

Results:
Fifteen subjects were identified with mean follow-up of 38 months. Distal failure occurred a mean of 60 days after index surgery, with history of minor trauma in 4 patients. Failures included 3-column Chance fracture (11) or instrumentation failure (4). Thirteen patients presented with back pain and/or acute kyphosis, whereas 2 asymptomatic patients presented with healed fractures. Two patients also developed new onset of severe lower extremity neurological deficit after fracture, which improved but never resolved after revision. A total of 13/15 subjects required revision surgery, typically within 1 week. Complications associated with revision surgery were encountered in 8 patients (62%). Major complications that required return to the operating room included 2 deep infections, 2 instrumentation failures, and dense lower extremity paralysis that improved after medial screw revision and decompression. At final follow-up, 10 patients are asymptomatic, 2 have persistent neurological deficit, 2 have chronic pain, and 1 has altered gait with gait aid requirement.

Conclusions:
This study analyzes a heterogenous cohort of spinal fusion patients who developed DJF from 3-column Chance fracture or instrumentation failure. Revision surgery is typically required, but has a high complication rate and can result in severe neurological deficit, highlighting the morbidity of this complication. It is unclear whether level of the lowest instrumented vertebra contributes to DJF. Increased awareness of junctional failure in children may prompt additional studies to further characterize risk factors and preventative strategies.

Level of Evidence:
Level IV—study-type case series.
Perforator Flaps Covering Alloplastic Materials in Full-Thickness Chest Wall Defects Reconstruction: A Safe Option?
Authors: Aubá Cristina , Cabello Álvaro , García-Tutor Emilio , Vila Antonio , Qiu Shan Shan , Torre Wenceslao 
Published: May 2017

Summary:
Large full-thickness chest wall reconstruction requires an alloplastic material to ensure chest wall stability, as well as a flap that provides good soft-tissue coverage. The choice not to use perforator flaps over any mesh or inert material is often based on the concern that the vascularization would be inadequate. However, perforator flaps have shown good results in several reconstructive fields, minimizing donor-site morbidity and offering versatility when local tissues are unavailable or affected by radiotherapy. In this study, we present 4 cases of patients with full-thickness chest wall defects that were repaired with a double Marlex mesh, acrylic cement (n = 2) or a double patch of Goretex (n = 2) in combination with perforator flaps (3 deep inferior epigastric artery perforators and 1 lumbar artery perforator flap). The results we obtained are encouraging, and we believe the use of perforator flaps in combination with alloplastic materials should be considered as a reliable option for full-thickness chest wall defect reconstruction.
A Quadrangular Flap Technique for Vermilion Repair in Unilateral Cleft Lip
Authors: Masuoka Hiromu 
Published: May 2017

Summary:
In unilateral cleft lip repair, the vermilion triangular flap technique reported by Noordhoff
1
and its modification are widely accepted for the augmentation of the vermilion height on the medial side of the cleft; however, these techniques do not focus on the deformity of the labial tubercle. In this article, we herein report a modified technique for vermilion repair that is focused on the labial tubercle. The muco-vermilion quadrangular flap was elevated from the lateral lip to augment the labial tubercle. As a result, the amount of labial tubercle is appropriate. Fifty-three consecutive unilateral cleft lip repairs were performed. In most cases, the amount of the labial tubercle was appropriate, and the curvature of free margin was preferable. The technique could reduce the number of scars on the vermilion by placing some of the suture lines on the oral surface and enabled the augmentation of the labial tubercle. In conclusion, the quadrangular flap can be considered an ideal flap for the construction of the vermilion.
The Use of Rapid Deployment Valves in Combined Aortic and Mitral Valve Surgery
Authors: Schlömicher Markus , Bechtel Matthias , Taghiyev Zulfugar , Al-Jabery Yazan , Lukas Haldenwang Peter , Moustafine Vadim , Thomas Strauch Justus 
Published: May 2017

Objective Patients undergoing multiple valve surgery represent a high-risk group who could potentially benefit from a reduction of cross-clamp and cardiopulmonary bypass times because prolonged bypass and cross-clamp times are considered independent risk factors for increased morbidity and mortality after cardiac surgery. Methods Between July 2013 and November 2014, 16 patients underwent rapid deployment aortic valve replacement with the EDWARDS INTUITY valve system in the setting of concomitant mitral disease. Fifteen patients showed mitral regurgitation, whereas one patient had severe mitral stenosis. Fourteen patients received mitral valve repair and two patients received biological mitral valve replacement. Tricuspid valve repair was performed additionally in two patients. The mean ± SD age was 72.8 ± 8.4 years, and the mean ± SD logistic EuroSCORE II is 8.7% ± 3.4%. Results Within a 30-day perioperative period, no patient was lost (n = 0). The mean ± SD follow-up time was 11 ± 2 months. At 1 year, the overall survival was 81% (n = 13). A mean ± SD transaortic gradient of 10.7 ± 2.3 mm Hg and a mean ± SD effective orifice area of 1.7 ± 0.3 cm2 were measured echocardiographically. No higher-grade paravalvular leak (aortic insufficiency > 1+) occurred. Eight patients (61%) had no residual mitral regurgitation, four patients (30%) showed trivial regurgitation (1/4), and one patient (7.3%) had moderate mitral regurgitation (2/4). No interference of the subannular stent frame with the reconstructed valve or the biological mitral prosthesis was seen. Conclusions Rapid deployment aortic valve replacement with the EDWARDS INTUITY valve system in combined aortic and mitral valve surgery can be performed safely with reproducible results. One-year follow-up data of this small series shows encouraging results potentially justifying the extension of the indication for rapid deployment valves to patients with concomitant mitral disease. Especially elderly patients undergoing multiple valve surgery may benefit from a reduction of cardiopulmonary bypass and myocardial ischemic times.
Hybrid Coronary Revascularization Has Improved Short-Term Outcomes but Worse Mid-Term Reintervention Rates Compared to Cabg
Authors: Xia Yu , Katz Abraham N. , Forest Stephen J. , Pyo Robert T. , Greenberg Mark A. , DeRose Joseph J. 
Published: May 2017

Objective We evaluated short-term outcomes and mid-term survival and reintervention of hybrid coronary revascularization versus conventional coronary artery bypass grafting using a propensity score matched cohort. Methods We conducted a retrospective review of patients undergoing surgery for multivessel coronary artery disease from 2007 to 2015 at a single institution. Patients were propensity matched 1:1 to receiving hybrid coronary revascularization or conventional bypass grafting by multivariate logistic regression on preoperative characteristics. Short-term outcomes were compared. Freedom from reintervention and death were assessed by Kaplan-Meier analysis, log-rank test, and Cox proportional hazards regression. Results Propensity score matching selected 91 patients per group from 91 hybrid and 2601 conventionally revascularized patients. Hybrid revascularization occurred with surgery first in 56 (62%), percutaneous intervention first in 32 (35%), and simultaneously in 3 (3%) patients. Median intervals between interventions were 3 and 36 days for surgery first and percutaneous intervention first, respectively. Preoperative characteristics were similar. Patients undergoing hybrid revascularization had shorter postoperative length of stay (median = 4 vs 5 days, P < 0.001), less postoperative transfusion (13.2% vs 34.1%, P = 0.001), and respiratory failure (0% vs 6.6%, P = 0.03). They were more likely to be discharged home (93.4% vs 71.4%, P < 0.001), with no difference in 30-day mortality ( P = 0.99), readmission ( P = 0.23), or mid-term survival ( P = 0.79). Hybrid revascularization was associated with earlier reintervention ( P = 0.02). Hazard ratios for reintervention and patient mortality of hybrid coronary revascularization versus conventional revascularization were 3.60 (95% confidence interval = 1.16–11.20) and 1.17 (95% confidence interval = 0.37–3.72), respectively. Conclusions Despite having favorable short-term outcomes and similar survival, hybrid coronary revascularization may be associated with earlier reintervention compared with conventional techniques.
A Contemporary Approach to Reoperative Aortic Valve Surgery
Authors: Smith Deane E. , Koeckert Michael S. , Vining Patrick F. , Zias Elias A. , Grossi Eugene A. , Galloway Aubrey C. 
Published: May 2017

Objective Although the benefits of minimally invasive valvular surgery are well established, the applicability of extending these techniques to reoperative aortic valve surgery is unknown. We evaluated our experience with a minimally invasive approach to this patient population. Methods From January 2010 to September 2015, 21 patients underwent reoperative isolated aortic valve replacement via a minimally invasive approach by a single surgeon. All patients had preoperative evaluation with computerized tomography and coronary catheterization. Surgical approaches were right anterior thoracotomy (6/21) or upper hemisternotomy (15/21). Central aortic cannulation was preferred with femoral artery cannulation used in four patients (19%). In patients with left internal mammary artery (LIMA) grafts, no attempt to dissect or occlude the graft was made. Cold blood cardioplegia was administered antegrade (12/21) or retrograde (9/21); systemic cooling with a mean low temperature of 27.5 °C was employed. Results Mean age was 75.1 years with a range from 33 to 92 years, and 67% (14/21) were male. All procedures were completed with a minimally invasive approach. Mean ± SD cross-clamp time was 51.5 ± 9.2 minutes. Fourteen patients had patent LIMA grafts. No aortic, LIMA, or cardiac injuries occurred. There were no hospital deaths nor occurrences of perioperative myocardial infarction, stroke, wound infection, renal failure, or endocarditis/sepsis. One patient required a reoperation for bleeding. Sixty-two percent of patients were discharged to home; mean ± SD length of stay was 6 ± 3 days. Conclusions With appropriate preoperative evaluation and careful surgical planning, a minimally invasive approach to reoperative aortic valve surgery can be performed in a safe and effective manner.
Comparative Study of Functional Grasp and Efficiency Between a 3D-Printed and Commercial Myoelectric Transradial Prosthesis Using Able-Bodied Subjects: A Pilot Study
Authors: Duong Tuan , Wagner Brandon , Abraham Tobin , Davidson Michael , Bains Gurinder , Daher Noha , Friedrich Alec 
Published: May 2017

ABSTRACT

Introduction
Upper-limb amputations make up 10% to 20% of the total amputations in the United States. Of the two million individuals currently living with limb loss, 30% to 50% do not wear their prosthesis regularly. This is a result of lack of education, lack of training, discomfort, poor cosmetics, and cost. Three-dimensional (3D) printing may provide a cost-effective alternative for upper-limb prostheses. The purpose of this pilot study was to test and compare efficiency and functional capabilities of a 3D-printed and commercially available manufactured myoelectric hand.

Materials and Methods
The research team designed a quasi-experimental, static group comparison trial. A box and blocks test was used to assess the efficiency of the i-limb and Limbitless Arm. The two prosthetic hands were tested over two visits with a 2-week crossover period. Two custom devices, to which the two hands attach distally, were created to accommodate the able-bodied subjects.

Results
Twenty-four able-bodied (mean age, 26.1 ± 4.2 yrs), healthy, right-hand–dominant participants were recruited for this study. There were 14 men and 10 women. The mean number of blocks using the Limbitless Arm was significantly lower than the i-limb. For trial 1, the mean was 8.4 ± 3.6 versus 12.9 ± 3.3 (P < 0.001). For trial 2, the mean was 8.3 ± 3.6 versus 13.8 ± 4.1 (P < 0.001). Furthermore, the mean number of blocks improved when using the i-limb versus the 3D-printed hand by 53.6% in trial 1 and 66.3% in trial 2. Similar findings were obtained when we ran the analyses separately for men (trial 1, the mean was 9.1 ± 3.3 vs. 12.9 ± 3.7, P = 0.01 and trial 2, the mean was 9.6 ± 3.2 vs. 14.1 ± 4.7, P = 0.02) and women (trial 1, the mean 7.5 ± 3.9 vs. 12.8 ± 2.9, P = 0.00 and trial 2, the mean 6.3 ± 3.4 vs. 13.4 ± 3.2, P = 0.00).

Conclusions
The results and observations made by the researchers suggested the i-limb was more efficient than the Limbitless Arm. There is a potential for 3D-printed prostheses to be a viable option for prosthetic care in the future with better development and technological advancements. However, at this point, myoelectric prostheses such as the i-limb are more practical and effective.