bluuebunny/crossref_metadata_2025_split huggingface dataset:
iPTF SEARCH FOR AN OPTICAL COUNTERPART TO GRAVITATIONAL-WAVE TRANSIENT GW150914
Authors: Kasliwal M. M. , Cenko S. B. , Singer L. P. , Corsi A. , Cao Y. , Barlow T. , Bhalerao V. , Bellm E. , Cook D. , Duggan G. E. , Ferretti R. , Frail D. A. , Horesh A. , Kendrick R. , Kulkarni S. R. , Lunnan R. , Palliyaguru N. , Laher R. , Masci F. , Manulis I. , Miller A. A. , Nugent P. E. , Perley D. , Prince T. A. , Quimby R. M. , Rana J. , Rebbapragada U. , Sesar B. , Singhal A. , Surace J. , Sistine A. Van 
Published: June 2016

ABSTRACT
The intermediate Palomar Transient Factory (iPTF) autonomously responded to and promptly tiled the error region of the first gravitational-wave event GW150914 to search for an optical counterpart. Only a small fraction of the total localized region was immediately visible in the northern night sky, due both to Sun-angle and elevation constraints. Here, we report on the transient candidates identified and rapid follow-up undertaken to determine the nature of each candidate. Even in the small area imaged of 126 deg2, after extensive filtering, eight candidates were deemed worthy of additional follow-up. Within two hours, all eight were spectroscopically classified by the Keck II telescope. Curiously, even though such events are rare, one of our candidates was a superluminous supernova. We obtained radio data with the Jansky Very Large Array and X-ray follow-up with the Swift satellite for this transient. None of our candidates appear to be associated with the gravitational-wave trigger, which is unsurprising given that GW150914 came from the merger of two stellar-mass black holes. This end-to-end discovery and follow-up campaign bodes well for future searches in this post-detection era of gravitational waves.
THE HUNT FOR PLANET NINE: ATMOSPHERE, SPECTRA, EVOLUTION, AND DETECTABILITY
Authors: Fortney Jonathan J. , Marley Mark S. , Laughlin Gregory , Nettelmann Nadine , Morley Caroline V. , Lupu Roxana E. , Visscher Channon , Jeremic Pavle , Khadder Wade G. , Hargrave Mason 
Published: June 2016

ABSTRACT
We investigate the physical characteristics of the solar system’s proposed Planet Nine using modeling tools with a heritage of studying Uranus and Neptune. For a range of plausible masses and interior structures, we find upper limits on the intrinsic

T

eff

, from ∼35 to 50 K for masses of 5–20 M
⊕, and we also explore lower

T

eff

values. Possible planetary radii could readily span from 2.7 to 6 R
⊕, depending on the mass fraction of any H/He envelope. Given its cold atmospheric temperatures, the planet encounters significant methane condensation, which dramatically alters the atmosphere away from simple Neptune-like expectations. We find that the atmosphere is strongly depleted in molecular absorption at visible wavelengths, suggesting a Rayleigh scattering atmosphere with a high geometric albedo approaching 0.75. We highlight two diagnostics for the atmosphere’s temperature structure: (1) the value of the methane mixing ratio above the methane cloud and (2) the wavelength at which cloud scattering can be seen, which yields the cloud-top pressure. Surface reflection may be seen if the atmosphere is thin. Due to collision-induced opacity of H2 in the infrared, the planet would be extremely blue instead of red in the shortest wavelength WISE colors if methane is depleted and would, in some cases, exist on the verge of detectability by WISE. For a range of models, thermal fluxes from ∼3 to 5 μm are ∼20 orders of magnitude larger than blackbody expectations. We report a search of the AllWISE Source Catalog for Planet Nine, but find no detection.
PROCESSO DE TOMADA DE DECISÃO QUANTO À POLÍTICA DE MANUTENÇÃO
Authors: Rodrigues Thiago De Almeida , Seleme Robson , Cleto Marcelo Gechele 
Published: June 2016

<p>As organizações atuam em cenários cada vez mais complexos e mutáveis, sendo influenciadas por fatores externos e internos que impactam nas tomadas de decisão. Entre estas, a definição de qual política de manutenção aplicar a determinado equipamento, buscando reduzir os custos e aumentar a eficiência, é de grande importância. A partir da necessidade de um processo estruturado que identifique as variáveis mais relevantes e detalhe as atividades que devem ser consideradas, definiu-se como objetivo elaborar um processo que auxilie na tomada de decisão quanto a qual política de manutenção aplicar a determinado equipamento. No processo proposto foram consideradas cinco análises para a tomada de decisão, entre elas a análise de custos, segurança, recursos e viabilidade, riscos e meio ambiente, onde cada uma poderá resultar em três possíveis políticas de manutenção sugeridas, a manutenção corretiva, preventiva ou preditiva. O resultado desta pesquisa foi um macro processo estruturado de tomada de decisão quanto à política de manutenção; é importante ressaltar que o processo proposto deve ser alinhado às especificidades da organização, logo, o mesmo serve como referência, levantando questionamentos relevantes à tomada de decisão e direcionando a organização.<em> </em></p>
ANÁLISE ERGONÔMICA DO TRABALHO CIRURGIÃO DENTISTA - DENTÍSTICA RESTAURADORA - ESTUDO DE CASO
Authors: De Oliveira Maciel Júnior Ari , Catai Rodrigo Eduardo 
Published: June 2016

<p><em>O estudo de caso a seguir foi realizado na sala de atendimento de um consultório odontológico na cidade de Curitiba, Paraná. Utilizando-se dos conceitos da ergonomia, realizou-se a análise ergonômica no local de trabalho do cirurgião dentista e as influências das condições técnicas, ambientais e organizacionais na saúde, qualidade de vida e produtividade do profissional. A metodologia adotada foi baseada nos procedimentos da análise ergonômica do trabalho (conversas e observações sistemáticas) identificando as situações mais danosas à saúde do profissional. Realizou-se o diagnóstico ergonômico bem como recomendações ergonômicas para melhoramento do conforto nas atividades laborais do cirurgião dentista. As posições mais inconfortáveis encontradas foram: sobrecarga de atividades, as tarefas intra-bucais na parte superior da arcada dentária e as distâncias inadequadas dos equipamentos periféricos fotopolimerizador e ultrassom. <del cite="mailto:CATAI" datetime="2015-04-28T22:13"> </del>Desta forma, seguiram-se as definições ergonômicas e a norma regulamentadora (NR-17), que visa a estabelecer padrões que favoreçam a adaptação das situações de trabalho às características psicofisiológicas dos trabalhadores, de modo a proporcionar um máximo de conforto, segurança e desempenho eficiente.</em></p>
Instrumented BASFI (iBASFI) Shows Promising Reliability and Validity in the Assessment of Activity Limitations in Axial Spondyloarthritis
Authors: Swinnen Thijs Willem , Milosevic Milica , Van Huffel Sabine , Dankaerts Wim , Westhovens Rene , de Vlam Kurt 
Published: June 2016

Objective.The Bath Ankylosing Spondylitis Functional Index (BASFI) is the most popular method to assess activity capacity in axial spondyloarthritis (axSpA), to our knowledge. It is endorsed by the Assessment of Spondyloarthritis international Society. But it may have recall bias or aberrant self-judgments in individual patients. Therefore, we aimed to (1) develop the instrumented BASFI (iBASFI) by adding a body-worn accelerometer with automated algorithms to performance-based measurements (PBM), (2) study the iBASFI’s core psychometric properties, and (3) reduce the number of iBASFI items.Methods.Twenty-eight patients with axSpA wore a 2-axial accelerometer while completing 12 PBM derived from the BASFI. A chronometer and both manual and “automated algorithm-based” acceleration segmentation identified movement time. Test-retest trials and methods (algorithm vs manual segmentation/chronometer/BASFI) were compared with ICC, standard error of measurement [percentage of movement time (SEM%)], and Spearman ρ correlation coefficients. Linear regression identified the optimal set of reliable iBASFI PBM.Results.Good to excellent test-retest reliability was found for 8/12 iBASFI items (ICC range 0.812–0.997, SEM range 0.4–30.4%), typically with repeated and fast movements. Automated algorithms excellently mimicked manual segmentation (ICC range 0.900–0.998) and the chronometer (ICC range 0.878–0.998) for 10/12 iBASFI items. Construct validity compared with the BASFI was confirmed for 7/12 iBASFI items (δ range 0.504–0.755). Together, sit-to-stand speed test (stBeta 0.483), cervical rotation (stBeta −0.392), and height (stBeta −0.375) explained 59% of the variance in the BASFI (p < 0.01).Conclusion.The proof-of-concept iBASFI showed promising reliability and validity in measuring activity capacity. The number of the iBASFI’s PBM may be minimized, but further validation in larger axSpA cohorts is needed before its clinical use.
The Minimum Clinically Important Improvement and Patient-acceptable Symptom State in the BASDAI and BASFI for Patients with Ankylosing Spondylitis
Authors: Kviatkovsky Milla Johanna , Ramiro Sofia , Landewé Robert , Dougados Maxime , Tubach Florence , Bellamy Nicholas , Hochberg Marc , Ravaud Philippe , Martin-Mola Emilio , Awada Hassane , Bombardier Claire , Felson David , Hajjaj-Hassouni Najia , Logeart Isabelle , Matucci-Cerinic Marco , van de Laar Mart , van der Heijde Désirée 
Published: June 2016

Objective.To establish cutoffs for the minimum clinically important improvement (MCII) and the patient-acceptable symptom state (PASS) for the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in patients with ankylosing spondylitis (AS).Methods.Patients with AS who started nonsteroidal antiinflammatory drugs were included. After 4 weeks, the PASS and the MCII were defined using external anchor questions (for the PASS, patients considering their condition of AS over the prior 48 h as “acceptable” forever; and for the MCII, those reporting moderate or slightly important improvement). Consistency of the MCII and PASS were tested according to HLA-B27 status, presence/absence of SpA extraarticular manifestations, age, sex, disease duration, and baseline BASDAI/BASFI score. The 75th percentile of the cumulative distribution was used to determine the MCII and PASS.Results.In total, 283 patients from a multinational cohort were included. Overall cutoffs for the PASS were 4.1 in the BASDAI and 3.8 in the BASFI. Cutoffs for the MCII were 0.7 and 0.4 for the BASDAI and BASFI, respectively. Subgroup analyses revealed that disease duration and baseline BASDAI/BASFI were significantly associated with the PASS and MCII. In a subanalysis limited to patients with active disease (baseline BASDAI ≥ 4), the MCII was 1.1 for the BASDAI and 0.6 for the BASFI.Conclusion.The conceptual viability of the PASS for the BASDAI is questionable because levels approach those required for the start of biological therapy. Because the MCII is less variable than the PASS, we propose its exclusive use, with cutoffs of 1.1/0.6 for the BASDAI/BASFI in patients with active disease. Because these values are based on a subset of the study population, we recommend confirmation in larger studies focused on patients with baseline BASDAI ≥ 4.
Gottron Papules and Gottron Sign with Ulceration: A Distinctive Cutaneous Feature in a Subset of Patients with Classic Dermatomyositis and Clinically Amyopathic Dermatomyositis
Authors: Cao Hua , Xia Qunli , Pan Meng , Zhao Xiaoqing , Li Xia , Shi Ruofei , Zhou Min , Ding Xiaoyi , Kuwana Masataka , Zheng Jie 
Published: June 2016

Objective.Gottron papules and Gottron sign are characteristic and possibly pathognomonic cutaneous features of classic dermatomyositis and clinically amyopathic dermatomyositis (DM/CADM). However, the Gottron papules/Gottron sign with cutaneous ulceration (ulcerative Gottron papules/Gottron sign) are less common. We aimed to clarify the clinical characteristics of patients with DM/CADM who have ulcerative Gottron papules/Gottron sign.Methods.Clinical features, laboratory findings, and prognosis of patients with DM/CADM who had Gottron papules/Gottron sign with or without ulceration were analyzed and compared.Results.Occurrences of acute interstitial pneumonia/subacute interstitial pneumonia (AIP/SIP) were significantly higher in patients with ulcerative Gottron papules/Gottron sign (19/26) versus patients with Gottron papules/Gottron sign without ulceration (2/66, p < 0.001). We also observed that the white blood cell counts (mean ± SD 4.2 ± 1.6 vs 6.9 ± 2.9; p < 0.001) and creatine kinase (CK) levels (198.0 ± 377.7 vs 1364.0 ± 2477.0; p = 0.019) were significantly lower, whereas the positive rate of antimelanoma differentiation-associated gene 5 antibody (anti-MDA5; 88.5% vs 6.1%, p < 0.001) and serum ferritin levels (665.2 ± 433.5 vs 256.2 ± 279.0, p < 0.001) were significantly higher in the patients with ulcerative Gottron papules/Gottron sign. Moreover, the cumulative survival rate of the group with ulcerative Gottron papules/Gottron sign was significantly lower (p < 0.001).Conclusion.Patients with DM/CADM who have ulcerative Gottron papules/Gottron sign, positive anti-MDA5 antibody, and significantly lower baseline CK level are at increased risk of interstitial lung disease, especially AIP/SIP. A new designation for this subgroup of patients should be established to draw more attention to this clinical entity.
Le « PT light » en campagne
Authors: Goirand Camille 
Published: June 2016

Depuis sa création en 1980, le Parti des travailleurs (PT) n’a pas cessé d’élargir son électorat, avec un tournant décisif au début des années 2000, représenté par l’élection de son dirigeant historique, Lula, à la présidence de la République. Avec l’accès à la gestion des affaires publiques, locales et nationales, ses dirigeants se sont professionnalisés en politique, leurs ressources se sont accrues, les équilibres internes à l’organisation ont été modifiés, de même que les modalités de l’ancrage social du parti. De ces changements, les campagnes électorales constituent un bon révélateur. Cet article s’appuie sur des matériaux ethnographiques recueillis à l’occasion de différentes campagnes électorales entre 1994 et 2010. Dans un premier temps, après avoir décrit le « temps de la politique » au Brésil, il montre la transformation des campagnes électorales du PT, au niveau national et au niveau local, dans l’État du Pernambouc. Dans un second temps, il rend compte de l’observation de plusieurs meetings organisés par des candidats locaux du PT, qui sont révélateurs de la segmentation de l’organisation, de l’individualisation des stratégies en son sein et de l’absence de linéarité dans le processus de changement.
Politisations différentielles et acculturations mutuelles en contexte autoritaire
Authors: Bennani-Chraïbi Mounia 
Published: June 2016

L’observation ethnographique des politisations différentielles pendant une campagne électorale en contexte autoritaire changeant est un analyseur privilégié de plusieurs processus. Sur un plan empirique, elle donne à voir les modalités diversifiées d’appropriation du moment électoral par les acteurs, les tentatives d’ajustement d’une partie de la gauche marocaine à la perte de son électorat de granit et aux transformations du marché électoral, mais également un mouvement de fond : celui de l’inversion ponctuelle du principe censitaire, en lien avec la désertion des urnes par les plus dotés culturellement et matériellement et avec la mutation du vote urbain populaire. Sur un plan théorique, l’examen des tâtonnements en œuvre – avant leur naturalisation – permet de poursuivre le dialogue entre les travaux sur le clientélisme politique et sur la politisation, au croisement des approches socio-historiques et de sociologie politique, en contextes autoritaires et démocratiques. Il montre l’intérêt de dépasser les oppositions entre conceptions restrictives et extensives de la politisation, pour se saisir processuellement et in situ des politisations différentielles des acteurs, des registres et des pratiques.
Quantitative Characteristics of Spectral-Domain Optical Coherence Tomography in Corresponding Areas of Increased Autofluorescence at the Margin of Geographic Atrophy in Patients With Age-Related Macular Degeneration
Authors: Hariri Amir H. , Nittala Muneeswar G. , Sadda SriniVas R. 
Published: June 2016

BACKGROUND AND OBJECTIVE:
To evaluate the spectral-domain optical coherence tomography (SD-OCT) characteristics of the junctional zone corresponding to areas of increased autofluorescence (IAF) at the margin of geographic atrophy (GA) in patients with age-related macular degeneration (AMD).

PATIENTS AND METHODS:
SD-OCT and fundus autofluorescence (FAF) images from untreated eyes with GA available from archived studies at Doheny Image Reading Center were evaluated. Areas of definite decreased autofluorescence (DDAF) corresponding to GA, and areas of IAF at the margins of the GA were manually segmented. Eyes with evidence of IAF were selected. Following manual registration of FAF and OCT data, areas of IAF and normal fluorescence were correlated with OCT features at these locations.

RESULTS:

Thirty eyes were included. The mean retinal pigment epithelium (RPE) thickness in areas of IAF was 40.6 µm ± 7.69 µm, compared to 28.8 µm ± 7.09 µm in normal adjacent areas (
P
< .001).

CONCLUSION:
Regions of IAF at the junctional zone of GA lesions appear to correspond to thickening of the presumed RPE band on OCT.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:523–527.]
Comparison of Ranibizumab 0.5 mg Versus 1.0 mg for the Treatment of Patients With Clinically Significant Diabetic Macular Edema: A Randomized, Clinical Trial
Authors: Ferrone Philip J. , Jonisch Jonathan 
Published: June 2016

BACKGROUND AND OBJECTIVE:To compare ranibizumab (Lucentis; Genentech, South San Francisco, CA) 0.5 mg and 1.0 mg for the treatment of clinically significant diabetic macular edema (CSDME).PATIENTS AND METHODS:This was a 12-month, prospective, single-masked, randomized clinical trial. Patients with CSDME secondary to diabetic retinopathy were randomized to receive 0.5 mg or 1.0 mg of ranibizumab by intravitreal injection once monthly for 3 months and then once every other month as needed.RESULTS:Patients received a mean of 6.5 injections in each group during the course of this 12-month study. The mean change in Early Treatment Diabetic Retinopathy Study visual acuity from baseline to month 12 was +3.8 letters in the ranibizumab 0.5-mg group (n = 23) and +7.9 letters in the 1.0-mg group (n = 23;P= .92 vs. 0.5 mg). Central foveal thickness (CFT) significantly decreased from baseline to month 12 in both dose groups.CONCLUSION:Treatment of CSDME with ranibizumab resulted in a statistically significant improvement in visual acuity (ranibizumab 1.0 mg) and decrease in CFT and macular volume (ranibizumab 0.5 mg and 1.0 mg) from baseline to 12 months.[Ophthalmic Surg Lasers Imaging Retina. 2016;47:536–543.]
Endophthalmitis Associated With Glaucoma Drainage Implants
Authors: Medina Carlos A. , Butler Michelle R. , Deobhakta Avnish A. , Banitt Michael R. , Albini Thomas A. , Smiddy William E. , Berrocal Audina M. , Gedde Steven J. , Flynn Harry W. 
Published: June 2016

BACKGROUND AND OBJECTIVE:
To identify the clinical features, organisms, and treatment outcomes in patients with endophthalmitis associated with glaucoma drainage implants.

PATIENTS AND METHODS:
A retrospective noncomparative case series.

RESULTS:

Of the 13 patients, exposure occurred in eight eyes, including exposure of the tube in four eyes, exposure of the patch graft in three eyes, and exposure of the plate in one eye. In the remaining five eyes, either recent implant placement or conjunctival revision occurred. The most common organism was
Staphylococcus epidermidis
(five eyes). Intravitreal antibiotics were administered in all eyes, with the exception of one eye (primary evisceration). Removal of the implant was performed in six eyes and evisceration or enucleation was performed in three eyes. Median pre-infection visual acuity was 20/80 (range: 20/30 to hand motion). Visual acuity at last follow-up was no light perception (five eyes), light perception (two eyes), hand motion (one eye), and better than or equal to 20/200 (five eyes).

CONCLUSION:

Clinical features associated with endophthalmitis include implant exposure and a history of recent surgery.
Staphylococcus epidermidis
was the most common isolate. Although removal of the implant was performed in many patients, successful treatment was accomplished in some patients without removal. Visual outcomes were generally poor.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:563–569.]
Laser Marking of the Meridian of Retinal Breaks at the Ora: A Novel Technique for Pneumatic Retinopexy
Authors: Yan Peng , Minaker Samuel , Mandelcorn Efrem D. 
Published: June 2016

BACKGROUND AND OBJECTIVE:
Localization of retinal breaks in rhegmatogenous retinal detachment (RRD) after pneumatic retinopexy (PR) can be challenging once the retina is reattached. Laser can be applied to the pigmented and always-attached ora serrata in the meridian of the retinal breaks prior to pneumatic retinopexy, resulting in subsequent rapid localization of the breaks even in the presence of a gas bubble or media opacity.

PATIENTS AND METHODS:
Ten cases of indirect laser photocoagulation marking at the ora prior to intraocular gas injection in PR for RRD. Subsequent laser retinopexy was completed 48 hours after utilizing the landmarks at the ora to localize the reattached retinal breaks.

RESULTS:
In all 10 cases, laser photocoagulation marking was easily applied to the ora in the meridian of the retinal breaks prior to gas injection with no complications. The retinal breaks were subsequently identified 48 hours after gas injection.

CONCLUSION:
Laser marking of the ora prior to pneumatic retinopexy is a rapid and effective way to localize the re-attached retina breaks.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:570–572.]
Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
Authors: Laugel Bruno , Lloyd Angharad , Meermeier Erin W. , Crowther Michael D. , Connor Thomas R. , Dolton Garry , Miles John J. , Burrows Scott R. , Gold Marielle C. , Lewinsohn David M. , Sewell Andrew K. 
Published: June 2016

Abstract
The nonclassical HLA molecule MHC-related protein 1 (MR1) presents metabolites of the vitamin B synthesis pathways to mucosal-associated invariant T (MAIT) cells and other MR1-restricted T cells. This new class of Ags represents a variation on the classical paradigm of self/non-self discrimination because these T cells are activated through their TCR by small organic compounds generated during microbial vitamin B2 synthesis. Beyond the fundamental significance, the invariant nature of MR1 across the human population is a tantalizing feature for the potential development of universal immune therapeutic and diagnostic tools. However, many aspects of MR1 Ag presentation and MR1-restricted T cell biology remain unknown, and the ubiquitous expression of MR1 across tissues and cell lines can be a confounding factor for experimental purposes. In this study, we report the development of a novel CRISPR/Cas9 genome editing lentiviral system and its use to efficiently disrupt MR1 expression in A459, THP-1, and K562 cell lines. We generated isogenic MR1−/− clonal derivatives of the A549 lung carcinoma and THP-1 monocytic cell lines and used these to study T cell responses to intracellular pathogens. We confirmed that MAIT cell clones were unable to respond to MR1−/− clones infected with bacteria whereas Ag presentation by classical and other nonclassical HLAs was unaffected. This system represents a robust and efficient method to disrupt the expression of MR1 and should facilitate investigations into the processing and presentation of MR1 Ags as well as into the biology of MAIT cells.