bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleeping Princesses and Beauties
Authors: Gupta Maureen 
Published: January 2017

Abstract
This article demonstrates that in his production of Sleeping Beauty for the American Ballet Theatre, Alexei Ratmansky proposes a softer style of ballet and reintegrates pantomime into the fabric of the ballet. His use of a choreographic text raises questions of “authenticity” and the intentions of Petipa, and how a notational text may collide with nontextual Sleeping Beauty traditions developed since the ballet’s premiere in 1890. This production also draws from Bakst’s gorgeous designs for the Ballets Russes London production of 1921–1922. By incorporating choreographic and design elements from the ballet’s history into his own creation, Ratmansky shows not only homage to past traditions, but also his own contemporary aesthetic. The article asserts that what emerges is an affirmation of the living tradition of this ballet that continues to instruct us even as we are challenged to consider new meaning in the older practices of this foundational ballet.
Archaic Shell Mounds in the American Southeast
Authors: Saunders Rebecca 
Published: January 2017

AbstractFreshwater and estuarine shellfish began to be exploited in the southeastern United States between 9000 and 7000 b.p. Shortly thereafter, shell mounds appeared in the mid-South Shell Mound Archaic, along the St. Johns River in peninsular Florida, and, somewhat later, in the Stallings Island area along the middle Savannah River. On the lower Atlantic and Gulf Coasts, shell rings arose. Until recently, all these mounds were considered middens—the accumulations of the remains of simple meals of mobile peoples who visited the same areas for hundreds or thousands of years. More recent scholarship indicates that these mounds were deliberate constructions—some of the first sculpted landscapes created by Archaic peoples to memorialize the past, celebrate the present, and provide for the future. In this chapter, recent research on shell sites in these four areas is discussed. The emphasis is on changing perspectives about the peoples who built them.
Pain Interference, Psychopathology, and General Medical Conditions Among Black and White Adults in the US General Population
Authors: Barry Declan T. , Glenn Corey Pilver , Hoff Rani A. , Potenza Marc N. 
Published: January 2017

Objectives:
To assess how race might moderate relationships between pain interference and psychopathology, and general medical conditions among a nationally representative sample of black and white adults.

Methods:
Chi-square tests and multivariable logistic regression analyses were performed on data from the National Epidemiologic Survey on Alcohol and Related Conditions on 32,474 adult respondents (25% black, 75% white), who were categorized according to 1 of 3 levels of pain interference (ie, no/low, moderate, or severe).

Results:
Pain interference was associated with race in bivariate analyses (P < .001); relative to white respondents, black respondents had lower rates of no/low pain interference (78.9% vs 80.3%), lower rates of moderate pain interference (6.8% vs 7.8%), and higher rates of severe pain interference (14.3% vs 11.9%). Pain interference was associated with past-year axis I psychiatric disorders in both black and white respondents (P < 0.001) with the largest odds typically observed in association with moderate or severe pain interference. A stronger relationship was observed in black as compared with white respondents between severe pain interference and any axis I disorder (odds ratio [OR] 1.28, P < 0.05) and alcohol abuse or dependence (OR 1.90, P < 0.05), and between moderate pain interference and tachycardia (OR 1.69, P < 0.05). In contrast, a weaker relationship was observed in black as compared with white respondents between moderate pain interference and any general medical condition (OR 0.70, P < 0.05).

Conclusions:
These findings underscore the complexity of race-related disparities in health and suggest the importance of further study of the possible mechanisms underlying the apparent differences between black and white groups in the relationships between pain interference, psychopathology, and general medical conditions.
Association of Hospital Volume With Racial and Ethnic Disparities in Locally Advanced Cervical Cancer Treatment
Authors: Uppal Shitanshu , Chapman Christina , Spencer Ryan J. , Jolly Shruti , Maturen Kate , Rauh-Hain J. Alejandro , delCarmen Marcela G. , Rice Laurel W. 
Published: January 2017

OBJECTIVE:
To evaluate racial–ethnic disparities in guideline-based care in locally advanced cervical cancer and their relationship to hospital case volume.

METHODS:
Using the National Cancer Database, we performed a retrospective cohort study of women diagnosed between 2004 and 2012 with locally advanced squamous or adenocarcinoma of the cervix undergoing definitive primary radiation therapy. The primary outcome was the race–ethnicity-based rates of adherence to the National Comprehensive Cancer Network guideline–based care. The secondary outcome was the effect of guideline-based care on overall survival. Multivariable models and propensity matching were used to compare the hospital risk-adjusted rates of guideline-based adherence and overall survival based on hospital case volume.

RESULTS:
The final cohort consisted of 16,195 patients. The rate of guideline-based care was 58.4% (95% confidence interval [CI] 57.4–59.4%) for non-Hispanic white, 53% (95% CI 51.4–54.9%) for non-Hispanic black, and 51.5% (95% CI 49.4–53.7%) for Hispanic women (P<.001). From 2004 to 2012, the rate of guideline-based care increased from 49.5% (95% CI 47.1–51.9%) to 59.1% (95% CI 56.9–61.2%) (P
trend<.001). Based on a propensity score-matched analysis, patients receiving guideline-based care had a lower risk of mortality (adjusted hazard ratio 0.65, 95% CI 0.62–0.68). Compared with low-volume hospitals, the increase in adherence to guideline-based care in high-volume hospitals was 48–63% for non-Hispanic white, 47–53% for non-Hispanic black, and 41–54% for Hispanic women.

CONCLUSION:
Racial and ethnic disparities in the delivery of guideline-based care are the highest in high-volume hospitals. Guideline-based care in locally advanced cervical cancer is associated with improved survival.
A Statewide Progestogen Promotion Program in Ohio
Authors: Iams Jay D. , Applegate Mary S. , Marcotte Michael P. , Rome Martha , Krew Michael A. , Bailit Jennifer L. , Kaplan Heather C. , Poteet Jessi , Nance Melissa , McKenna David S. , Walker Hetty C. , Nobbe Jennifer , Prasad Lakshmi , Macaluso Maurizio , Lannon Carole 
Published: January 2017

OBJECTIVE:
To promote use of progestogen therapy to reduce premature births in Ohio by 10%.

METHODS:
The Ohio Perinatal Quality Collaborative initiated a quality improvement project in 2014 working with clinics at 20 large maternity hospitals, Ohio Medicaid, Medicaid insurers, and service agencies to use quality improvement methods to identify eligible women and remove treatment barriers. The number of women eligible for prophylaxis, the percent prescribed a progestogen before 20 and 24 weeks of gestation, and barriers encountered were reported monthly. Clinics were asked to adopt protocols to identify candidates and initiate treatment promptly. System-level changes were made to expand Medicaid eligibility, maintain Medicaid coverage during pregnancy, improve communication, and adopt uniform data collection and efficient treatment protocols. Rates of singleton births before 32 and 37 weeks of gestation in Ohio hospitals were primary outcomes. We used statistical process control methods to analyze change and generalized linear mixed models to estimate program effects accounting for known risk factors.

RESULTS:
Participating sites tracked 2,562 women eligible for treatment between January 1, 2014, and November 30, 2015. Late entry to care, variable interpretation of treatment guidelines, maintenance of Medicaid coverage, and inefficient communication among health care providers and insurers were identified as treatment barriers. Births before 32 weeks of gestation decreased in all hospitals by 6.6% and in participating hospitals by 8.0%. Births before 32 weeks of gestation to women with prior preterm birth decreased by 20.5% in all hospitals, by 20.3% in African American women, and by 17.1% in women on Medicaid. Births before 37 weeks of gestation were minimally affected. Adjusting for risk factors and birth clustering by hospital confirmed a program-associated 13% (95% confidence interval 0.3–24%) reduction in births before 32 weeks of gestation to women with prior preterm birth.

CONCLUSION:
The Ohio progestogen project was associated with a sustained reduction in singleton births before 32 weeks of gestation in Ohio.
Pathologically Diagnosed Placenta Accreta and Hemorrhagic Morbidity in a Subsequent Pregnancy
Authors: Roeca Cassandra , Little Sarah E. , Carusi Daniela A. 
Published: January 2017

OBJECTIVE:
To identify the relationship between pathologically diagnosed placenta accreta and risk of major morbidity in a subsequent pregnancy.

METHODS:
We conducted a retrospective cohort study of patients with pathologically diagnosed placenta accreta in an index pregnancy who returned with a subsequent pregnancy at our academic center from 2007 to 2015. Subsequent delivery outcomes included minor, major, or no morbidity. Minor morbidity included estimated blood loss 500–1,500 cc for vaginal and 1,000–1,500 cc for cesarean delivery, transfusion of one to three units of red cells, and minor surgical procedures. Major morbidity included estimated blood loss greater than 1,500 cc, transfusion of greater than three units of red cells, uterine artery embolization, unplanned laparotomy, or hysterectomy.

RESULTS:
Three hundred thirty-nine patients with pathologically diagnosed accreta did not undergo hysterectomy, and 39 (11.5%) of these returned for subsequent delivery. Of these, 14 (36%) had accretas that had been identified clinically in the index pregnancy. Twenty-one (54%) experienced morbidity in the index pregnancy, 16 of these (76%) minor and five (24%) major. Of patients without morbidity in the first pregnancy, none experienced major morbidity in a subsequent pregnancy, whereas 6 of 21 (29%) with any index morbidity had a subsequent major morbid outcome (P=.02). Of those with a morbid index delivery, 25% had either a clinical or pathologic accreta diagnosis at follow-up compared with none of those who index accreta was nonmorbid (P=.05).

CONCLUSION:
Risk for major hemorrhagic morbidity after a prior pathologically diagnosed accreta depends on the clinical context. Preparation for major blood loss is indicated after any prior pregnancy complicated by hemorrhage or treatment of retained placenta with a pathologic accreta.
Subspecialty Influence on Scientific Peer Review for an Obstetrics and Gynecology Journal With a High Impact Factor
Authors: Parikh Laura I. , Benner Rebecca S. , Riggs Thomas W. , Hazen Nicholas , Chescheir Nancy C. 
Published: January 2017

OBJECTIVE:
To evaluate whether quality of peer review and reviewer recommendation differ based on reviewer subspecialty in obstetrics and gynecology and to determine the role of experience on reviewer recommendation.

METHODS:
We performed a retrospective cohort study of reviews submitted to Obstetrics & Gynecology between January 2010 and December 2014. Subspecialties were determined based on classification terms selected by each reviewer and included all major obstetrics and gynecology subspecialties, general obstetrics and gynecology, and nonobstetrics and gynecology categories. Review quality (graded on a 5-point Likert scale by the journal's editors) and reviewer recommendation of “reject” were compared across subspecialties using χ2, analysis of variance, and multivariate logistic regression.

RESULTS:
There were 20,027 reviews from 1,889 individual reviewers. Reviewers with family planning subspecialty provided higher-quality peer reviews compared with reviewers with gynecology only, reproductive endocrinology and infertility, gynecologic oncology, and general obstetrics and gynecology specialties (3.61±0.75 compared with 3.44±0.78, 3.42±0.72, 3.35±0.75, and 3.32±0.81, respectively, P<.05). Reviewers with gynecology-only subspecialty recommended rejection more often compared with reviewers with a nonobstetrics and gynecology subspecialty (57.7% compared with 38.7%, P<.05). Editorial Board members recommended rejection more often than new reviewers (68.0% compared with 41.5%, P<.05). Increased adjusted odds of manuscript rejection recommendation were associated with reproductive endocrinology, female pelvic medicine and reconstructive surgery, and gynecology-only reviewer subspecialty (adjusted odds ratio [OR] 1.23 [1.07–1.41], 1.21 [1.05–1.39], and 1.11 [1.02–1.20]). Manuscript rejection recommendation rate was also increased for reviewers who had completed the highest quintile of peer reviews (greater than 195) compared with the lowest quintile (one to seven) (adjusted OR 2.85 [2.60–3.12]).

CONCLUSION:
Peer review quality differs based on obstetrics and gynecology subspecialty. Obstetrics and gynecology subspecialty and reviewer experience have implications for manuscript rejection recommendation. Reviewer assignment is pivotal to maintaining a rigorous manuscript selection process.
Osteoporosis: fracture epidemiology update 2016
Authors: Cauley Jane A. 
Published: January 2017

Purpose of review
The purpose of this review is to provide an update on osteoporosis epidemiology. The focus is on fractures because fractures are the most important clinical consequence of osteoporosis. Studies published over the past 18 months are identified and reviewed. Finally, the clinical impact of these new findings is discussed.

Recent findings
Important research in 2015–2016 include analyses of screening and rescreening in younger women and older men, risk factors for hip fractures in older men, obesity and weight loss/gain, and risk of fracture. Several dietary factors, including adherence to a Mediterranean diet and a diet rich in protein, fruits, and vegetables and maintenance of physical function with increasing age represent modifiable nonpharmacologic risk factors that improve bone health. Sarcopenia may have a more important role in fracture in men than women. Important biomarkers for fracture include low 25-hydroxyvitamin D and hemoglobin A1c.

Summary
Updated literature on fracture epidemiology have identified important risk factors for fracture.
SURGICAL OUTCOMES AND COMPLICATIONS OF RHEGMATOGENOUS RETINAL DETACHMENT IN EYES WITH CHORIORETINAL COLOBOMA
Authors: Abouammoh Marwan A. , Alsulaiman Sulaiman M. , Gupta Vishali S. , Younis Afnan , Chhablani Jay , Hussein Abdullah , Casella Antonio M. , Banker Alay S. , Arevalo J. Fernando ,   for the King Khaled Eye Specialist Hospital (KKESH) International Collaborative Retina Study Group
Published: January 2017

Purpose:
To study the outcomes of management of rhegmatogenous retinal detachment in eyes with chorioretinal colobomas.

Methods:
A retrospective review of 119 patients (119 eyes) with chorioretinal colobomas who underwent surgical repair for rhegmatogenous retinal detachment was performed. Data were collected on the site of the retinal break, type of surgery, anatomical success, and complications.

Results:
The most common location of the primary retinal break was the intercalary membrane in 58.8% of eyes. The most common surgical intervention was vitrectomy with endolaser and silicone oil tamponade (77.3% of eyes). Final anatomical success was achieved in 87.4% of eyes. Anatomical success was significantly higher in eyes that received long-acting tamponade (P = 0.006). Cryotherapy was significantly associated with failure of primary vitrectomy (P = 0.028). Placement of an encircling band did not affect anatomical outcomes (P = 0.75). Most of the eyes (60%) with recurrent retinal detachment after primary vitrectomy had a primary break within the normal retina.

Conclusion:
The optimal option for managing retinal detachment in eyes with chorioretinal colobomas is pars plana vitrectomy with long-acting tamponade (silicone oil or octafluoropropane) and retinopexy to the edge of the coloboma and the primary breaks. Cryotherapy is associated with poor anatomical outcomes. An encircling band does not seem to affect the final anatomical outcome.
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY CHANGES IN EARLY TYPE 3 NEOVASCULARIZATION AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT
Authors: Miere Alexandra , Querques Giuseppe , Semoun Oudy , Amoroso Francesca , Zambrowski Olivia , Chapron Thibaut , Capuano Vittorio , Souied Eric H. 
Published: January 2017

Purpose:
To investigate the morphologic changes on optical coherence tomography angiography (OCTA) of treatment-naive Type 3 neovascularization secondary to exudative age-related macular degeneration after 1 year of anti–vascular endothelial growth factor therapy.

Methods:
Consecutive patients diagnosed with treatment-naive early-stage Type 3 neovascularization were enrolled in this retrospective study. All patients underwent color fundus photographs/MultiColor (Heidelberg Engineering) imaging, fluorescein angiography, indocyanine green angiography, structural spectral domain OCT, and OCTA Optovue RTVue XR Avanti (Optovue) at baseline, and repeated OCTA and structural spectral domain OCT at Month 12. Qualitative analysis of the 3 × 3 OCTA examinations at baseline and Month 12 was then compared, to assess changes after anti–vascular endothelial growth factor therapy.

Results:
A total of 15 treatment-naive eyes of 15 consecutive patients were included in the analysis. At 12-month follow-up after pro-re-data anti–vascular endothelial growth factor therapy (5.75 ± 1.48 injections of ranibizumab, and injections of 6.33 ± 1.21 of aflibercept), OCTA demonstrated persistence of the deep capillary plexus abnormalities in 13/15 eyes. In the outer retina and choriocapillaris, the initial lesion became undetectable in 7/15 cases, accompanied by choriocapillaris atrophy. The abnormal vascular complex persisted in the form of a tuft-shaped lesion in the outer retinal segmentation in 9/15 eyes, which in the choriocapillaris segmentation was associated with sub–retinal pigment epithelium neovascularization in 8 cases.

Conclusion:
Optical coherence tomography angiography showed that the tuft-shaped abnormal outer retinal lesion, frequently associated with a small clew-like flow signal in the choriocapillaris, after 1 year of anti–vascular endothelial growth factor therapy, either becomes undetectable or develops sub–retinal pigment epithelium neovascularization.
Dyserythropoiesis of myelodysplastic syndromes
Authors: Lefèvre Carine , Bondu Sabrina , Le Goff Salomé , Kosmider Olivier , Fontenay Michaela 
Published: January 2017

Purpose of review
Myelodysplastic syndromes (MDS) are heterogeneous diseases of the hematopoietic stem cell in the elderly. Anemia is the main symptom that mostly correlates with dysplastic erythropoiesis in the bone marrow. We will review the recent advances in understanding the diverse mechanisms of dyserythropoiesis.

Recent findings
Dyserythropoiesis defined as 10% dysplastic erythroid cells in the bone marrow is found in more than 80% of early MDS. Immature erythroblasts accumulate at the expense of mature erythroblasts due to differentiation arrest and apoptosis. In early MDS with dyserythropoiesis, caspase-dependent cleavage of the erythroid transcription factor GATA-1 occurring in basophilic erythroblasts accounts for impairment of final maturation. Depending on initiating genetic alteration, specific mechanisms contribute to erythroid defect. In MDS with 5q deletion, the haploinsufficiency of ribosomal protein gene, RPS14, opposes the transition of immature to mature erythroblasts by inducing a p53-dependent ribosome stress, cell cycle arrest and apoptosis. Recent work identifies the activation of a p53-S100A8/9 innate immune pathway that both intrinsically and extrinsically contributes to defective erythropoiesis. In MDS with ring sideroblasts, a paradigm of dyserythropoiesis, a unique mutation in SF3B1 splicing factor gene induces a multiplicity of alterations at RNA level that deeply modifies the patterns of gene expression.

Summary
Insights in the pathophysiology of MDS with dyserythropoiesis may guide the choice of the appropriate therapy, for instance lenalidomide in MDS with del(5q). A better understanding of the mechanisms of dyserthropoiesis is required to treat anemia in non-del(5q) MDS, especially in case of resistance to first-line therapy by erythropoiesis-stimulating agents.
Feasibility of Using HIV Care-Continuum Outcomes to Identify Geographic Areas for Targeted HIV Testing
Authors: Castel Amanda D. , Kuo Irene , Mikre Meriam , Young Toni , Haddix Meredith , Das Suparna , Maugham Geoffrey , Reisen Carol 
Published: January 2017

Background:
Improved detection and linkage to care of previously undiagnosed HIV infections require innovative approaches to testing. We sought to determine the feasibility of targeted HIV testing in geographic areas, defined by continuum of care parameters, to identify HIV-infected persons needing linkage or engagement in care.

Methods:
Using HIV surveillance data from Washington, DC, we identified census tracts that had an HIV prevalence >1% and were either above (higher risk areas—HRAs) or below (lower risk areas—LRAs) the median for 3 indicators: monitored viral load, proportion of persons out of care (OOC), and never in care. Community-based HIV rapid testing and participant surveys were conducted in the 20 census tracts meeting the criteria. Areas were mapped using ArcGIS, and descriptive and univariate analyses were conducted comparing the areas and participants.

Results:
Among 1471 persons tested, 28 (1.9%) tested HIV positive; 2.1% in HRAs vs. 1.7% in LRAs (P = 0.57). Higher proportions of men (63.7% vs. 56.7%, P = 0.007) and fewer blacks (91.0% vs. 94.6%, P = 0.008) were tested in LRAs vs. HRAs; no differences were observed in risk behaviors between the areas. Among HIV-positive participants, 54% were new diagnoses (n = 9) or OOC (n = 6), all were Black, 64% were men with a median age of 51 years.

Conclusions:
Although significant differences in HIV seropositivity were not observed between testing areas, our approach proved feasible and enabled identification of new diagnoses and OOC HIV–infected persons. This testing paradigm could be adapted in other locales to identify areas for targeted HIV testing and other reengagement efforts.