bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH CORPORATE REBRANDING RUMAH SAKIT AWAL BROS MENJADI PRIMAYA HOSPITAL PADA LOYALITAS PASIEN DI TANGERANG
Authors: Mirza Mochammad 
Published: September 2024

Abstrak

Riset Ini bertujuan untuk memahami seberapa besar dampak yang diberi upaya Re branding yang dilakukan oleh rumah sakit Awal bros menjadi Primaya Hospital. Perubahan yang dilakukan baik berupa perubahan nama, termasuk slogan dan pelayanan yang prima yang ingin diberikan kepada para pasien atau calon pasien mereka yang diharapkan berpengaruh terhadap citra institusi rumah sakit tersebut. Teori yang digunakan dalam riset ini adalah manajemen citra organisasi. Pendekatan yang dilakukan adalah kuantitatif dengan metode yang digunakan berupa Explanatory survey. Pulasi yang digunakan merupakan pasien dari Primaya Hospital dengan 98 pasien yang dianggap mewakili populasi tersebut. Kumpulan data yang dilakukan peneliti dengan melakukan kuisioner dan pendekatan triangulasi. Kuesioner dianggap merupakan elemen penting di dalam penelitian yang telah di uji validitas dan reabilitasnya berbasis pada Pearson Product Moment. Di mana data yang dihasilkan berupa kuisioner yang akan memberikan gambaran bahwa memberikan pelayanan yang prima kepada pasien dan perubahan logo dari Primaya hospital sendiri ternyata memiliki dampak yang signifikan dan pengaruh yang besar. Berdasarkan riset yang telah peneliti lakukan ini memberikan gambaran bahwa memberikan pelayanan yang prima dan perubahan logo mempengaruhi citra rs persen pada pasien baik pasien Rawat inap ataupun Rawat jalan. Dan perubahan nama termasuk slogan yang digunakan saat ini tidak memiliki pengaruh yang banyak terhadap citra dari rumah sakit tersebut secara signifikan. Dapat ditarik kesimpulan bahwa Rebranding yang dilakukan oleh Primaya Hospital telah memberikan dampak yang positif terhadap citra primaya Hospital terhadap pasiennya.

Keyword : Rebranding, Citra Perusahaan, Primaya Hospital
How does interpersonal curiosity impact peer rejection? The mediating effect of relative deprivation and malicious envy
Authors: He Jiali , Liu Hanshu 
Published: September 2024

ObjectivePeer rejection is one of the key indicators for measuring interpersonal relationships among adolescents. Considering that interpersonal curiosity plays a significant role in interpersonal relationships, however, the influence of interpersonal curiosity on peer rejection is still unknown. This study is grounded in social comparison theory and aims to investigate the impact of adolescent interpersonal curiosity on peer rejection. The study explores the impact of interpersonal curiosity on peer rejection and further investigates the mediating role of relative deprivation and malicious envy.MethodsThe study employed the stratified cluster sampling method to select 418 adolescents in Shaanxi Province. The Adolescents' Relative Deprivation Scale was used to measure relative deprivation, the Benign and Malicious Envy Scale was used to measure benign envy and malicious envy, and the School Adaptation Inventory was used to measure peer rejection. The statistical software SPSS 24.0 and AMOS 24.0 were used for statistical analysis, and the common method deviation test was conducted using the Harman single-factor control method. Finally, the bootstrap sampling method was used to test the significance of the intermediary effect.ResultsThe results of the mediation model show that interpersonal curiosity can directly and positively affect peer rejection (β = 0.317, p &lt; 0.001). Malicious envy plays a completely mediating role (b = 0.125, p &lt; 0.001), while relative deprivation plays a partially mediating role (bdirect − path = 0.071, p = 0.004; bindirect − path = 0.064, p &lt; 0.001). Further discovery of the chain mediation model shows that interpersonal curiosity can impact individual peer rejection through the chain mediation of relative deprivation and malicious envy (b = 0.026, p &lt; 0.001), and there is no significant gender difference in this result.ConclusionInterpersonal curiosity can enhance peer rejection in adolescents, with relative deprivation and malicious envy completely mediating this process. This study reveals the impact of interpersonal curiosity on adolescents' peer rejection from the viewpoint of social comparison theory and provides a new perspective for fostering the formation and growth of positive peer relationships among adolescents.
A systematic review of the methodology for examining the relationship between obstructive sleep apnea and type two diabetes mellitus
Authors: Taimah Manal , Juber Nirmin F. , Holland Paula , Brown Heather 
Published: September 2024

BackgroundThe association between obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM) has been explored in various studies, revealing inconsistent correlations that impact therapeutic effectiveness. This heterogeneity in findings requires further exploration to understand what may be driving this. Therefore, this study focuses on systematically reviewing the data, classification of variables, and analytical approach to understand if and how this may be contributing to the mixed findings. This review aims to provide insights that can enhance the generalisability of future research findings.MethodsA comprehensive electronic search was conducted, including EMBASE, MEDLINE, PsycINFO, CINAHL, Web of Science Core Collection, Scopus and specialised sleep journals. The included studies were observational studies published in English from 2011 onwards, involving adults above 18 years with OSA and T2DM or prediabetes, and included a control group. Exclusions were pregnant women, interventional studies, randomised trials, systematic reviews, conference abstracts, case studies and studies without a control group or only with descriptive analysis.ResultsWe reviewed 23 studies that met the inclusion criteria. Among cohort studies, 54% did not report attrition rates, and 52% did not detail methods for handling missing data in all studies. Nine studies (39%) predominantly included male participants. Objective measures were prevalent in assessing OSA, with 11 using home portable sleep monitors and four employing clinic polysomnography, though only three validated home sleep monitors. The apnea-hypopnea index was commonly used to define OSA severity, with six studies adapting the American Academy of Sleep Medicine criteria. Two studies utilised validated self-report questionnaires for OSA symptoms. T2DM diagnosis methods varied, with 17 studies using blood samples, two relying only on self-reporting, and four confirmed diagnosis via medical records.ConclusionsThe variability in sample characteristics, data quality, and variable coding may contribute to the mixed finding. This review identifies gaps in using the standardised measures, reporting attrition rates, handling missing data, and including both sexes. Addressing these issues is crucial to enhancing future research generalisability. Standardising diagnostic criteria, considering clinical and sociodemographic factors, and ensuring inclusivity in study populations are essential for advancing understanding and treatment strategies for OSA and T2DM.Protocol registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023397547.
The relationship between cardiometabolic index and infertility in American adults: a population-based study
Authors: Cheng Huifang , He Xiaoli , Jin Xiaoke 
Published: September 2024

BackgroundInfertility is a fertility disorder caused by various factors, with lipid metabolism playing a crucial role in its development. The cardiometabolic index (CMI), which combines blood lipids (TG/HDL-C) and obesity-related parameters (WHtR), is a new quantitative indicator. This study used NHANES data to investigate the relationship between CMI and the incidence of infertility.MethodsWe utilized data from women who took part in the National Health and Nutrition Examination Survey (NHANES) from 2015 to March 2020 to calculate the CMI index. Subsequently, we used multivariate logistic regression, smooth curve fitting, and subgroup analysis to investigate the relationship between the CMI index and infertility.ResultsThe logistic regression model revealed a significant positive correlation between the CMI index and infertility, even after adjusting for all confounding variables (OR=3.23, 95%CI: 1.55-6.73, p=0.0017). This association remained consistent across all subgroups (p&gt;0.05 for all interactions). Smooth curve fitting demonstrated a positive nonlinear relationship between CMI and infertility. However, the CMI index had limited diagnostic power for infertility (AUC=0.60, 95%CI: 0.56-0.65). However, the CMI-BMI index combined with BMI had good predictive performance (AUC=0.722, 95%CI: 0.676-0.767).ConclusionThe CMI index shows a positive correlation with infertility, but its diagnostic value is restricted. The combination with BMI has good diagnostic value. Further investigation is required to determine the effectiveness of the CMI index as an early indicator of infertility.
Association between cardiovascular health assessed by life’s essential 8 and hyperuricemia in U.S. adults: the NHANES 2009-2020
Authors: Wang Meng , Meng Heyu 
Published: September 2024

BackgroundThis study presented the new Life’s Essential 8 (LE8) framework for examining cardiovascular health (CVH) to analyze the potential relationship between the latter and hyperuricemia (HUA) in the U.S. population.MethodsData on individuals aged at least 20 years were collected from the National Health and Nutrition Examination Survey (NHANES) 2009-2020. Smoothed curve fitting and multivariate logistic regression analyses were then performed on a sample of 25,681 adults to explore the association between LE8 and HUA. A sensitivity analysis was conducted to examine the robustness of the research findings.ResultsThe study found a strong negative association between LE8 and HUA, with an odds ratio (OR) of 0.71 and a 95% confidence interval (CI) from 0.69 to 0.73 after adjusting for multiple confounding factors. The sensitivity analysis further validated the robustness of this association. This analysis consistently showed negative associations across different genders, ages, races, and education levels (p &lt; 0.05), but there were no significant relationships with marital status. The association between uric acid levels and LE8 displayed an inverted L-shaped curve, with an inflection point around 41.43.ConclusionsThe findings indicate a strong negative relationship between LE8 and HUA among the U.S. population, suggesting that higher scores on the LE8, which assesses CVH, were associated with reduced uric acid levels. The consistent negative association underscores the LE8 framework’s potential as a valuable tool for understanding and managing HUA in CVH.
Design and implementation of online battery monitoring and management system based on the internet of things
Authors: Chen Kena , Luo Lei , Lei Wei , Lv Pinlei , Zhang Liang 
Published: September 2024

Battery pack provides the backup power supply for DC system of power substations. In the event of an AC power outage or other accidents, it is an important guarantee for the reliable operation of power substation. To prevent possible failures, batteries usually require careful maintenance. Common methods are online monitoring, condition assessments, and health management. Among these, model-based techniques are widely used for battery monitoring and prognostics optimization. Data-driven methods are a good alternative solution when no mathematical models are available. As substations develop towards intelligent and unmanned modes, this paper proposes an online battery monitoring and management system based on the “cloud-network-edge-end” Internet of Things (IoT) architecture. Firstly, advanced battery monitoring system based on IoT architecture is reviewed in depth. It provides basis for later designing. Secondly, the battery online monitoring and management system is designed considering functional requirements and data link. Designing functions include ledger management, basic battery information display, real-time display of battery monitoring data, and the visualization of battery alarm information. It can implement online monitoring and intelligent maintenance management for battery operating status. Finally, the designed and developed system is applied in a 110 kV offshore substation, mainly providing battery maintenance suggestions and fault alarm prompts. Typical results of ledger information management, key parameter monitoring and alarm prompt are presented. This verifies the effectiveness and convenience of IoT-based system for the monitoring and management of batteries.
Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection
Authors: van Linge Christine C. A. , Kullberg Robert F.J. , Chouchane Osoul , Roelofs Joris J. T. H. , Goessens Wil H. F. , van ‘t Veer Cornelis , Sirard Jean-Claude , de Vos Alex F. , van der Poll Tom 
Published: September 2024

ObjectiveAntimicrobial resistance is an emerging problem and multi-drug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae) represents an enormous risk of failing therapy in hospital-acquired pneumonia. The current study aimed to determine the immunomodulatory effect of topical flagellin in addition to antibiotic treatment during respiratory infection evoked by hypervirulent antibiotic-susceptible and antibiotic-resistant K. pneumoniae in mice.MethodsC57BL6 mice were inoculated intranasally with hypervirulent K. pneumoniae (K2:O1) which was either antibiotic-susceptible or multi-drug resistant. Six hours after infection, mice were treated with antibiotics intraperitoneally and flagellin or vehicle intranasally. Mice were sacrificed 24 hours after infection. Samples were analyzed for bacterial loads and for inflammatory and coagulation markers.ResultsFlagellin therapy induced neutrophil influx in the lung during antibiotic-treated pneumonia evoked by either antibiotic-susceptible or -resistant K. pneumoniae. The pulmonary neutrophil response was matched by elevated levels of neutrophil-attracting chemokines, neutrophil degranulation products, and local coagulation activation. The combined therapy of effective antibiotics and flagellin did not impact K. pneumoniae outgrowth in the lung, but decreased bacterial counts in distant organs. Neutrophil depletion abrogated the flagellin-mediated effect on bacterial dissemination and local coagulation responses.ConclusionTopical flagellin administration as an adjunctive to antibiotic treatment augments neutrophil responses during pneumonia evoked by MDR-K. pneumoniae, thereby reducing bacterial dissemination to distant organs.
Case report: Concurrent MOG antibody-associated disease and latent infections in two patients
Authors: Kulsvehagen Laila , Woelfle Tim , Ayroza Galvão Ribeiro Gomes Ana Beatriz , Lipps Patrick , Neziraj Tradite , Flammer Julia , Leuzinger Karoline , Derfuss Tobias , Kuhle Jens , Papadopoulou Athina , Pröbstel Anne-Katrin 
Published: September 2024

ObjectivesMyelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is frequently preceded by infections. The underlying pathomechanism, however, remains poorly understood. Here, we present the clinical data of two MOGAD patients with concurrent syphilis infection and investigate the reactivity of patient-derived antibodies to MOG and Treponema pallidum (T. pallidum).MethodsLongitudinal serum samples and soluble immunoglobulins in single B cell supernatants were measured for MOG reactivity by a live cell-based assay. Reactivity against T. pallidum was assessed by enzyme-linked immunosorbent assay.ResultsThe two patients presented MOGAD and concurrent latent syphilis infection, manifesting as cervical myelitis and unilateral optic neuritis, respectively. The first patient had been living with HIV on antiretroviral therapy, and the second was concomitantly diagnosed with chronic hepatitis B infection. Upon screening of B cell supernatants, we identified reactivity to MOG or T. pallidum. Notably, one B cell showed reactivity to both antigens.DiscussionThe coexistence of MOGAD diagnoses and latent syphilis, alongside the identification of antibody reactivity to MOG and T. pallidum, underscores the potential pathomechanistic link between syphilis infection and subsequent autoimmune neuroinflammation. Cross-reactivity between MOG and T. pallidum antibodies remains to be validated on a molecular level, and further characterization of infectious triggers associated with MOGAD is needed.
Photographic scale for the characterization of actinic keratosis through reflectance confocal microscopy: a quantitative approach to cellular transformation
Authors: Guerra Lucas Offenbecker , Leão Santos Ana Carolina , Cortinoz Janaina Rosa , Magalhães Renata Ferreira , Vasques Louise Idalgo , Leonardi Gislaine Ricci 
Published: September 2024

BackgroundActinic keratosis (AK) is a highly prevalent pre-cancerous skin lesion that often leads to cutaneous squamous cell carcinoma. There are different stages of evolution of the disease and several features that characterize keratosis. This study aimed to develop a qualitative and quantitative visual diagnostic tool to facilitate the identification of the characteristics and severity of the main cellular attributes of AK and to show its applicability in evaluating the evolution or treatment through image analysis.MethodsLiterature research on the main scientific databases and in the institute’s database was carried out to gather all the different levels of cellular transformation. To validate the scale, a preliminary characterization study was carried out with 21 subjects who had clinically diagnosed AK lesions to classify the attributes in each skin layer and test the accuracy of the diagnosis of the scale. Afterward, and to show the possibility of a follow-up with a topical treatment, the subjects were divided into two treatment groups, receiving either a cream formulation containing retinoic acid, or a placebo formula. The evaluation was carried out through confocal reflectance microscopy and a digital camera with dermoscopic quality before and after 90 days of treatment.ResultsA table detailing the 18 attributes of AK, and a photographic scale containing RCM images graded by scores established for each characteristic and the frequency of spreading were developed. The results of the validation presented good repeatability, correlation with clinical evaluation, and capacity for differentiating treatments demonstrated by the significant improvement after topical treatment by the reduction of the score for 10 out of the 18 attributes. The preliminary study, evaluated by the detailed transformation scale highlights important differences in the subclinical approach that allows a deeper evaluation of the aspects of the lesion’s re-incidence even after fully treated skin sites.ConclusionThis study brings an innovative method based on RCM, to assist in the quantification of cell transformation level, provide early diagnosis, and deliver a powerful treatment evaluation tool to provide smoother treatment, as well as prevent re-incidence in the cases.
A synthetic lung model (ASYLUM) for validation of functional lung imaging methods shows significant differences between signal-based and deformation-field-based ventilation measurements
Authors: Voskrebenzev Andreas , Gutberlet Marcel , Klimeš Filip , Kaireit Till F. , Shin Hoen-oh , Kauczor Hans-Ulrich , Welte Tobias , Wacker Frank , Vogel-Claussen Jens 
Published: September 2024

IntroductionValidation of functional free-breathing MRI involves a comparison to more established or more direct measurements. This procedure is cost-intensive, as it requires access to patient cohorts, lengthy protocols, expenses for consumables, and binds working time. Therefore, the purpose of this study is to introduce a synthetic lung model (ASYLUM), which mimics dynamic MRI acquisition and includes predefined lung abnormalities for an alternative validation approach. The model is evaluated with different registration and quantification methods and compared with real data.MethodsA combination of trigonometric functions, deformation fields, and signal combinations were used to create 20 synthetic image time series. Lung voxels were assigned either to normal or one of six abnormality classes. The images were registered with three registration algorithms. The registered images were further analyzed with three quantification methods: deformation-based or signal-based regional ventilation (JVent/RVent) analysis and perfusion amplitude (QA). The registration results were compared with predefined deformations. Quantification methods were evaluated regarding predefined amplitudes and with respect to sensitivity, specificity, and spatial overlap of defects. In addition, 36 patients with chronic obstructive pulmonary disease were included for verification of model interpretations using CT as the gold standard.ResultsOne registration method showed considerably lower quality results (76% correlation vs. 92/97%, p ≤ 0.0001). Most ventilation defects were correctly detected with RVent and QA (e.g., one registration variant with sensitivity ≥78%, specificity ≥88). Contrary to this, JVent showed very low sensitivity for lower lung quadrants (0–16%) and also very low specificity (1–29%) for upper lung quadrants. Similar patterns of defect detection differences between RVent and JVent were also observable in patient data: Firstly, RVent was more aligned with CT than JVent for all quadrants (p ≤ 0.01) except for one registration variant in the lower left region. Secondly, stronger differences in overlap were observed for the upper quadrants, suggesting a defect bias in the JVent measurements in the upper lung regions.ConclusionThe feasibility of a validation framework for free-breathing functional lung imaging using synthetic time series was demonstrated. Evaluating different ventilation measurements, important differences were detected in synthetic and real data, with signal-based regional ventilation assessment being a more reliable method in the investigated setting.