bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: 2‐(SUBSTITUTED PHENOXYMETHYL)‐3‐(THIADIAZOL‐2‐YL)‐4‐QUINAZOLONES AS HYPOGLYCEMIC AGENTS
Authors: HUSAIN M. I. , GUPTA K. B. 
Published: May 2016

AbstractDie Chinazolone (III) werden durch Reaktion von Aminothiadiazolen (I) mit Anthranilsäureamiden (II) hergestellt und auf hxßglykämische Wirkung geprüft.
ChemInform Abstract: FACILE FORMATION OF 1,3‐DISUBSTITUTED 2,3,5,6‐TETRAHYDRO‐2‐THIOXOPYRIMIDIN‐4(1H)‐ONES AND 2‐N,3‐DISUBSTITUTED 2,3,5,6‐TETRAHYDRO‐2‐IMINO‐1,3‐THIAZIN‐4‐ONES FROM THIOUREAS AND β‐HALOACYL HALIDES
Authors: OKAWARA T. , NAKAYAMA K. , FURUKAWA M. 
Published: May 2016

AbstractDie Thioharnstoff e (I) reagieren mit dem Chlorpivalsäurechlorid (IIa) zu den eyclischen Acylharnstoffen (III).
ChemInform Abstract: SYNTHESIS OF MACROCYCLIC AMIDES. FORMATION OF A NEW SYMMETRIC 36‐MEMBERED TETRAMIDE RING
Authors: OKUNO Y. , HORITA K. , YONEMITSU O. 
Published: May 2016

AbstractAus dem Cyclooctanonoxim (I) erhält man über mehrere Stufen die geschützte ("o‐Aminosäure (II), die in den Aminosäureester (III) übergeführt wird.
ChemInform Abstract: SILA DRUGS. 30. (2‐AMINOETHYL)CYCLOALKYLPHENYLSILANOLS: BIOISOSTERIC CARBON/SILICON EXCHANGE IN PARASYMPATHOLYTICS OF THE TRIHEXYPHENIDYL, CYCRIMINE, AND PROCYCLIDINE TYPE
Authors: TACKE R. , STRECKER M. , LAMBRECHT G. , MOSER U. , MUTSCHLER E. 
Published: May 2016

AbstractDie Synthese der Titelsilanole (VI) erfolgt ausgehend von Dichlorophenylvinylsilan (IIa), dem Grignardierungsprodukt des Trichlorids (I), in der aufgezeichneten finfstufigen Reaktionsfolge mit einer Gesamtausb.
ChemInform Abstract: 1‐SUBSTITUTED SILATRANE‐3,7,10‐TRIONES
Authors: VORONKOV M. G. , BASENKO S. V. , MIRSKOV R. G. , VITKOVSKII V. YU. , TORYASHINOVA D. D. 
Published: May 2016

AbstractAus Trialkyl‐methoxy‐stannan (I) und Aminotriessigsäure (II) entstehen die Stannylester der Aminotriessigsäure (III).
ChemInform Abstract: DEHYDROCONDENSATION OF HYDROGEN‐CONTAINING CYCLOSILOXANES
Authors: MARTYNOVA T. N. , KORCHKOV V. P. 
Published: May 2016

AbstractDehydrokondensation der Wasserstoff‐haltigen Cyclosiloxane (I) führt in alkalischem Medium unter Rückfluß‐Bedingungen bei hohen Anfangskonzentrationen der Ausgangsstoffe zu dem Oligomeren‐Gemisch (IV).
ChemInform Abstract: A CYCLIC PHOSPHATE: BASE AND METAL ACETATE CATALYZED RING OPENING
Authors: WADSWORTH W. G. , WADSWORTH W. S. JUN. 
Published: May 2016

AbstractSechsgliedrige Ringphosphate ohne eine leicht abspaltbare Gruppe unterwerfen sich einer Methanolyse unter Bildung acyclischer Produkte, die bei Ringschluß die cyclischen Ausgangsverbindungen zurückbilden.
ChemInform Abstract: PHOTOCHEMICAL REACTIONS OF PHOSPHAALKENES
Authors: MERIEM A. , MAJORAL J.‐P. , REVEL M. , NAVECH J. 
Published: May 2016

AbstractBei der Photolyse in Methanol/Benzol erhält man aus dem Phosphaalken (I) neben den cyclischen oligomeren Phenylphosphinen (II) und (III) die P‐Verbindungen (IV), (V) und (VI); bei weiterer Photolyse erhält man ausschließlich (V) und (VI).
ChemInform Abstract: ACYL‐SUBSTITUTED VINYL ETHERS OF 1,3,2‐DIOXAPHOSPHOLANES
Authors: KOZENASHEVA L. YA. , SMIRNOVA T. V. , KOLESOVA V. A. , VIRIN L. I. 
Published: May 2016

AbstractAus Acetessigester (II) und 2‐Chlor‐4‐methyl‐ bzw. 2‐Chlor‐4,5‐dimethyl‐l ,3,2‐dioxaphospholan (I) lassen sich die 2‐O‐( l ‐Methyl‐2‐ethoxycarbonylvinyl)‐dioxaphospholane (III) herstellen.
ChemInform Abstract: STUDIES ON THE CHEMISTRY OF ARSOLES, 1,1‐DICHLORO‐1‐R‐Λ5‐ARSOLES, 1‐CHLOROARSOLES, 2,2′,5,5′‐TETRAPHENYLDIARSOLYL
Authors: MAERKL G. + , HAUPTMANN H. 
Published: May 2016

Abstract2,5‐Diphenyl‐1‐R‐arsole (I) reagieren mit Phenyliodiddichlorid (II) zu den 1,1‐Dichlor‐2,5‐diphenyl‐1‐R‐λ5‐arsolen (III), die leicht zum 1‐Chlor‐2,5‐diphenylarsol (IV) zerfallen.
ChemInform Abstract: SYNTHETIC APPLICATIONS OF TITANOCENE METHYLENE COMPLEXES: SELECTIVE FORMATION OF KETONE ENOLATES AND THEIR REACTIONS
Authors: STILLE J. R. , GRUBBS R. H. 
Published: May 2016

AbstractDas aus dem labilen Titanocyclobutan (I) unter Isobutylen‐Eliminierung entstehende Methylentitanocen (II) bildet mit den Säurechloriden (III) die Enolate (IV).
ChemInform Abstract: ARYL ISOMERIZATION DURING ALIPHATIC CARBON‐HYDROGEN BOND ACTIVATION
Authors: CHAMBERLAIN L. R. , ROTHWELL I. P. 
Published: May 2016

AbstractDie l z3‐molare Umsetzung des Trichlorodiphenoxy‐Ta‐Komplexes (I) mit den Tolyl‐Li‐Reagenzien (IIa) bis (IIc) führt zu den cyclometallierten Di‐tolyl‐Ta‐Verbindungen (IIIa‐c), die isomerenrein sind.
ChemInform Abstract: HIGHLY REDUCED ORGANOMETALLICS. 13. SYNTHESIS AND CHEMISTRY OF THE TRICARBONYLNITROSYLMANGANATE(2‐) ION, MN(CO)3NO2‐
Authors: CHEN Y.‐S. , ELLIS J. E. 
Published: May 2016

AbstractDas l(‐ und Na‐Salz (II) des Titelions werden durch die aufgezeichneten Reduktionen synthetisiert und durch Elementaranalyse (IIa), IR‐spektroskopische Daten und chemische Reaktionen charakterisiert.
ChemInform Abstract: DO COMPLEXES OF COMPOSITION MNLX2 (L = TERTIARY PHOSPHINE) REALLY EXIST? DO THEY REVERSIBLY BIND DIOXYGEN?
Authors: BURKETT H. D. , NEWBERRY V. F. , HILL W. E. , WORLEY S. D. 
Published: May 2016

AbstractAnhand eingehender IR‐spektroskopischer Untersuchungen, wobei ein Mn(ll)‐Salz wie Mnßr, direkt in einer IR‐Zelle mit wasserfreiem Dampf eines tert.‐Phosphins z.B.PMe3 zur Reaktion gebracht wird, wird gezeigt, daß ein Komplex Mnßr, PMe3 existiert.
ChemInform Abstract: UNIQUE HIGH‐SPIN‐LOW‐SPIN TRANSITION OF THE CENTRAL ION IN A LINEAR, TRINUCLEAR IRON(II) TRIAZOLE COMPOUND
Authors: VOS G. , LE FEBRE R. A. , DE GRAAFF R. A. G. , HAASNOOT J. G. , REEDIJK J. 
Published: May 2016

AbstractDer lineare dreikernige Fetlh‐Komplex (I), dargestellt durch 1:3‐molare Umsetzung von Hexaaquo‐Fe(lIHrifluormethansulfonat mit 4‐Ethyl‐l ,2,4‐triazol, wird durch IR‐, Ligandenfeld‐ und Mößbauer‐Spektren, Messungen magnetischer Suszeptibilitüten bei verschiedenen Temp. (2‐300 K) und Kristallstrukturbestimmungen bei 105 und 300 K (RG P5 l c, Z=2) charakterisiert.
ChemInform Abstract: SYNTHETIC ROUTES TO IRON SULFIDE (FE2S2, FE3S4, FE4S4, AND FE6S9), CLUSTERS FROM THE COMMON PRECURSOR TETRAKIS(ETHANETHIOLATE)FERRATE(2‐) ION ((FE(SC2H5)4)2‐): STRUCTURES AND PROPERTIES OF (FE3S4(SR)4)3‐ AND BIS(ETHANETHIOLATE)NONATHIOXOHEXAFERRATE(4‐) ION ((FE6S9(SC2H5)2)4‐), EXAMPLES OF THE NEWEST TYPES OF FE‐S‐SR CLUSTERS
Authors: HAGEN K. S. , WATSON A. D. , HOLM R. H. 
Published: May 2016

AbstractDer tetraedrische, stark reaktive Fe(II)‐Komplex (I) dient als Vorläufer zum Aufbau von Fe‐S‐SR‐Clustern.
ChemInform Abstract: KINETICS AND MECHANISM OF THE FORMATION OF NITROSOALKANE COMPLEXES BY MIGRATORY INSERTION OF COORDINATED NITRIC OXIDE INTO COBALT‐CARBON BONDS
Authors: WEINER W. P. , BERGMAN R. G. 
Published: May 2016

AbstractDie Reduktion des Dimeren (I) führt zum Salz (II), das mit Alkyliodiden in THF bei ‐40°C die Nitrosylkomplexe (III) ergibt.
ChemInform Abstract: INTRAMOLECULAR ELECTRON TRANSFER IN A SERIES OF MIXED‐VALENCE COPPER(II)‐COPPER(I) COMPLEXES
Authors: LONG R. C. , HENDRICKSON D. N. 
Published: May 2016

AbstractDie Dikupfer?ll‐Komplexe (I) (n: 2) mit gleichen Brücken X = Ywerden durch l : 1:1‐molare Umsetzung von CuUD‐tetrafluoroborat, dem Diamin und 2,6‐Diformyl‐4‐tert.‐butylphenol in siedendem Methanol dargestellt.
ChemInform Abstract: SYNTHESIS, STRUCTURE, AND PHOTOCHEMISTRY OF TETRACARBONYL(FULVALENE)DIRUTHENIUM. THERMALLY REVERSIBLE PHOTOISOMERIZATION INVOLVING CARBON‐CARBON BOND ACTIVATION AT A DIMETAL CENTER
Authors: VOLLHARDT K. P. C. , WEIDMAN T. W. 
Published: May 2016

AbstractDie Umsetzung von Dihydrofulvalen mit Octacarbonyldicobalt in siedendem Methylenchlorid bzw. mit Dodecacarbonyltriruthenium oder/und Hexacarbonyl‐M0 in siedendem Glyme führt zu den Komplexen (I) und (II).
ChemInform Abstract: ACTIVATION OF CARBON‐HYDROGEN BONDS IN SATURATED HYDROCARBONS ON PHOTOLYSIS OF (η5‐C5ME5)(PME3)IRH2. RELATIVE RATES OF REACTION OF THE INTERMEDIATE WITH DIFFERENT TYPES OF CARBON‐HYDROGEN BONDS AND FUNCTIONALIZATION OF THE METAL‐BOUND ALKYL GROUPS
Authors: JANOWICZ A. H. , BERGMAN R. G. 
Published: May 2016

AbstractDie Bestrahlung der wie aufgezeigt synthetisierten Dihydridkomplexe (II) in gesättigten Kohlenwasserstoffen führt zur Freisetzung von H, und Aufspaltung von C‐H‐Bindungen unter Bildung der Hydrido‐alkyl‐Komplexe (III).
ChemInform Abstract: SYNTHESIS AND DYEING CHARACTERISTICS OF SOME NEW ARYLAZOPYRAZOLE DERIVATIVES
Authors: FAHMY S. M. , EL‐HOSAMI M. , EL‐GAMAL S. , ELNAGDI M. H. 
Published: May 2016

AbstractDie Arylazopyrazole (I) werden zu den Diazoniumchloriden (II) diazotiert.
ChemInform Abstract: BILE PIGMENT STUDIES ‐ VI. SYNTHESES OF MODEL SYSTEMS
Authors: SMITH K. M. , KISHORE D. 
Published: May 2016

AbstractDie Synthese verschiedener Gallenfarbstoff‐Modellverbindungen aus Monopyrrolen und durch Ringspaltung von intakten Metalloporphyrinen und Metallochlorinen (bekannte Ergebnisse) wer‐ ′ den diskutiert.
ChemInform Abstract: SAPONINS FROM THE ROOTS OF P. ELATIOR (L.) SCHREBER. CONSTITUTION OF A MINOR SAPONIN AND REVISION OF THE SUGAR CHAIN OF THE MAIN SAPONIN
Authors: TSCHESCHE R. , WAGNER R. , WIDERA W. 
Published: May 2016

AbstractAus den Wurzeln und Rhizomen der Titelspezies wurden neben dem Hauptsapogenin (II) (PS 4) 4 Nebensaponine isoliert.
ChemInform Abstract: SYNTHESIS OF 7,8‐DIDEHYDRODESMOSTEROL
Authors: SCHOENAUER K. + , ZBIRAL E. 
Published: May 2016

AbstractDie Synthese der Titelverbindung (IXb) erfolgt ausgehend vom bekannten Hydroxydinorcholaenon (Ia) sukzessiv über die angegebenen Stufen; das Phosphor‐Ylid (VI) spielt dabei eine wichtige Rolle ( Reaktion (Ve)‐(VII) bzw. (VIIIa) ‐+ (VIIIb)].
ChemInform Abstract: SYNTHESIS OF 29‐FLUOROPHYTOSTEROLS: A NOVEL CLASS OF INSECT‐ACTIVATED SELECTIVE POISONS
Authors: PRESTWICH G. D. , PHIRWA S. 
Published: May 2016

AbstractAus dem Aldehyd (I) entstehen über die stereoisomeren Addukte (II) die isomeren 29‐Fluorphytosterole (III), jeweils in sterisch einheitlicher Form.
ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF RACEMIC DAUNOSAMINE. DIASTEREOFACIAL SELECTIVITY IN A NITRONE CYCLOADDITION
Authors: DESHONG P. , LEGINUS J. M. 
Published: May 2016

AbstractDie Titelverbindung (VIa), charakterisiert als Diacetylderivat (VIb), ist durch eine hochdiastereoselektive Cycloaddition des aus dem Ester (I) erhältlichen Nitrons (III) an das achirale Dipolarophil (IV) [ ‐+ (V)] und nachfolgende Hydrierung unter Spaltung der O‐N‐Bindung zugänglich (Gesamtausb.
ChemInform Abstract: SYNTHESIS OF NOVEL L‐RISTOSAMINE DERIVATIVES
Authors: SZTARICSKAI F. , PELYVAS I. , BOGNAR R. , TAMAS J. 
Published: May 2016

AbstractDas Mesylat (‐IIb) des Methylristosaminids (IIa) wird durch Reduktion des Mesylats (Ib) [erhältlich aus dem Azidozukker (Ia)] gewonnen.
ChemInform Abstract: Bausteine von Oligosacchariden. 47. Mitt. Synthese von Tri‐ und Tetrasaccharid‐Sequenzen von N‐Glycoproteinen mit β‐D‐mannosidischer Verknüpfung.
Authors: PAULSEN H. , LEBUHN R. 
Published: May 2016

AbstractDie im Kohlenhydrat‐Teil von N‐Glycoproteinen enthaltenen Trisaccharide (VIII), (X) sowie das Schlüssel‐Tetrasaccharid (IX) werden synthetisiert: Ausgehend vom Allylierungsprodukt (Ib) der Anhydromannopyranose (Ia) und unter Einsatz der Komponenten (III) und (V) wird über die Stufen (IIa), (IIb), (IVa), (IVb) und (VIa) das Azido‐trisaccharid (VIb) dargestellt, aus dem über die Verbindungen (VIIa)+(VIIb) [Gemisch der α‐ und β‐Anomeren von (VIIa)+(VIIb); Weitereinsatz ohne Reinigung] (VIII) gewonnen wird.
ChemInform Abstract: SYNTHESES OF 2‐ACETAMIDO‐2‐DEOXY‐4‐O‐β‐D‐GALACTOPYRANOSYL‐D‐GLUCOPYRANOSE (N‐ACETYLLACTOSAMINE) DERIVATIVES
Authors: ITOH Y. , TEJIMA S. 
Published: May 2016

AbstractAus Acetobromgalactose (1) erhält man mit der Anhydroglucopyranose (II) das Disaccharid (I11), das in die verschiedenen Derivate (IV) übergeführt wird.
ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐CHAENORHINE
Authors: WASSERMAN H. H. , ROBINSON R. P. , CARTER C. G. 
Published: May 2016

AbstractDie Synthese der Titelverbindung (X) gelingt ausgehend von den Schlüssel‐Komponenten (IV) und (VIIb) sukzessiv über die Stufen (VIIIa), (VIIIb), (lXa), (IXb) und (lXc).
ChemInform Abstract: SEMISYNTHETIC β‐LACTAM ANTIBIOTICS. IX. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7‐(2‐(2‐AMINOTHIAZOL‐4‐YL)‐2‐SULFOACETAMIDO)CEPHALOSPORANIC ACID AND ITS DERIVATIVES
Authors: MINAMI I. , AKIMOTO H. , KONDO M. , NOMURA H. 
Published: May 2016

AbstractFür die Cephalosporine (VIII) werden ausgehend von der Thiazolylmethylsulfonsäure (III) und den Cephalosporinen (X) wie im Formelschema ersichtlich verschiedene Synthesewege ausgearbeitet.
ChemInform Abstract: Synthetic Studies on Virginiamycin M2: A Useful Model Experiment for Construction of the 1,3‐Oxazole Moiety. Synthetic Studies on Virginiamycin M2: Functionalization at the 2‐Methyl Group of 4‐t‐Butoxycarbonyl‐2‐methyl‐1,3‐oxazole.
Authors: NAGAO Y. , YAMADA S. , FUJITA E. 
Published: May 2016

AbstractEine Metallierung und definierte Umsetzung des Esters (Ib) war nicht möglich.
ChemInform Abstract: SYNTHESIS OF (1S)‐(‐)‐FRONTALIN
Authors: MEISTER C. , SCHARF H.‐D. 
Published: May 2016

AbstractDie Titelverbindung (VII), das Aggregationspheromon des Borkenkäfers Dendroctonus frontalis, wird in hoher optischer Reinheit ausgehend vom Epoxid (II) ‐ "das seinerseits aus dem Alkohol (I) zugänglich ist ‐ synthetisiert.
ChemInform Abstract: CARBOXYLATION AND ALKOXYCARBONYLATION OF OLEFINS, 1,3‐ALKADIENES, AND ACETYLENES
Authors: TEMKIN O. N. , BRUK L. G. , SHULYAKOVSKII G. M. 
Published: May 2016

AbstractReview: Über Bedingungen, katalytische Systeme und die technische Anwendung der Carbonylierung von Olefinen zur Herstellung von Carbonsäureestern und Carbonsätiren, die Hydrocarboxylierung und Hydrocarbalkoxylierung von 1,3‐Dienen, die Carbonylierung von Acetylen für die Synthese von Acrylsäure und Acrylsäureestern sowie einige technische Syntheseanlagen wird zusammenfassend berichtet.
Subclinical Vascular Disease and Subsequent Erectile Dysfunction: The Multiethnic Study of Atherosclerosis (MESA)
Authors: Feldman David I. , Cainzos‐Achirica Miguel , Billups Kevin L. , DeFilippis Andrew P. , Chitaley Kanchan , Greenland Philip , Stein James H. , Budoff Matthew J. , Dardari Zeina , Miner Martin , Blumenthal Roger S. , Nasir Khurram , Blaha Michael J. 
Published: May 2016

ABSTRACTBackgroundThe association between subclinical cardiovascular disease and subsequent development of erectile dysfunction (ED) remains poorly described.HypothesisAmong multiple subclinical atherosclerosis and vascular dysfunction measurements, coronary artery calcium (CAC) score best predicts ED.MethodsAfter excluding participants taking ED medications at baseline, we studied 1862 men age 45 to 84 years free of known cardiovascular disease from the Multi‐Ethnic Study of Atherosclerosis (MESA) with comprehensive baseline subclinical vascular disease phenotyping and ED status assessed at MESA visit 5 (9.4 ± 0.5 years after baseline) using a standardized question on ED symptoms. Multivariable logistic regression was used to assess the associations between baseline measures of vascular disease (atherosclerosis domain: CAC, carotid intima‐media thickness, carotid plaque, ankle‐brachial index; vascular stiffness/function domain: aortic stiffness, carotid stiffness, brachial flow‐mediated dilation) and ED symptoms at follow‐up.ResultsMean baseline age was 59.5 ± 9 years, and 839 participants (45%) reported ED symptoms at follow‐up. Compared with symptom‐free individuals, participants with ED had higher baseline prevalence of CAC score >100 (36.4% vs 17.2%), carotid intima‐media thickness Z score >75th percentile (35.3% vs 16.6%), carotid plaque score ≥2 (39% vs 21.1%), carotid distensibility <25th percentile (34.6% vs 17.1%), aortic distensibility <25th percentile (34.2% vs 18.7%), and brachial flow‐mediated dilation <25th percentile (28.4% vs 21.3%); all P < 0.01. Only CAC >100 (odds ratio: 1.43, 95% confidence interval: 1.09‐1.88) and carotid plaque score ≥2 (odds ratio: 1.33, 95% confidence interval: 1.02‐1.73) were significantly associated with ED.ConclusionsSubclinical vascular disease is common in men who later self‐report ED. Early detection of subclinical atherosclerosis, particularly advanced CAC and carotid plaque, may provide opportunities for predicting the onset of subsequent vascular ED.
Blinatumomab treatment of older adults with relapsed/refractory B‐precursor acute lymphoblastic leukemia: Results from 2 phase 2 studies
Authors: Kantarjian Hagop M. , Stein Anthony S. , Bargou Ralf C. , Grande Garcia Carlos , Larson Richard A. , Stelljes Matthias , Gökbuget Nicola , Zugmaier Gerhard , Benjamin Jonathan E. , Zhang Alicia , Jia Catherine , Topp Max S. 
Published: May 2016

BACKGROUNDOlder adults with relapsed/refractory B‐precursor acute lymphoblastic leukemia (r/r ALL) are reported to have a poor prognosis and few therapeutic options. In the current study, the authors evaluated treatment with single‐agent blinatumomab in adults aged ≥65 years with r/r ALL.METHODSA total of 261 adults with r/r ALL who were examined across two phase 2 studies received blinatumomab in cycles of 4‐week continuous infusion and 2‐week treatment‐free intervals. The primary endpoint in each study was complete remission (CR) or CR with partial hematologic recovery (CRh) during the first 2 cycles. Data were pooled and analyzed according to patient age at screening (aged ≥65 years vs aged <65 years).RESULTSOf 36 older adults, 56% (95% confidence interval [95% CI], 38%‐72%) achieved CR/CRh during the first 2 cycles compared with 46% (225 patients) (95% CI, 40%‐53%) of younger adults. Complete minimal residual disease responses were 60% in older and 70% in younger responders. Three older responders (15%) and 61 younger responders (59%) proceeded to allogeneic hematopoietic stem cell transplantation. Kaplan‐Meier curves overlapped for relapse‐free and overall survival for both age groups. Older adults were found to have a similar incidence of grade ≥3 adverse events (AEs) as younger adults (86% vs 80%) but more grade ≥3 neurologic events (28% vs 13%). Cytokine release syndrome occurred in 7 older (19%) (1 case of grade 3) and 23 younger (10%) (4 cases of grade ≥3) adults. There were no treatment‐related fatal AEs reported.CONCLUSIONSOlder adults with r/r ALL who were treated with single‐agent blinatumomab were found to have similar hematologic response rates and incidence of grade ≥3 AEs compared with younger adults but had more neurologic events, which were reversible and primarily resolved with treatment interruption. Cancer 2016;122:2178–85. © 2016 American Cancer Society.
“Being a good patient” during times of illness as defined by adolescent patients with cancer
Authors: Weaver Meaghann S. , Baker Justin N. , Gattuso Jami S. , Gibson Deborah V. , Hinds Pamela S. 
Published: May 2016

BACKGROUNDAdolescents with cancer cite the opinions of others and expected impact on others as formative for their care preferences and decisions. The current study first explores how the concepts of being a good child and being a good patient may exist for adolescents with cancer and determines how adolescents describe and apply these concepts. The study then investigates parental actions and clinician behaviors perceived by adolescents with cancer as supportive in helping them to achieve their defined good child and good patient roles.METHODSIn a prospective study conducted at 2 cancer treatment centers over the course of 10 months, 40 adolescents with cancer responded to 10 open‐ended questions. Semantic content analysis was used. An adolescent focus group validated the findings.RESULTSOf the 40 participants in the current study, 39 confirmed 1 or both concepts; the good patient responses yielded 112 codes and 5 themes: cooperation, adherence, communication, self‐care, and care for others. The good child responses revealed 88 codes and 7 themes: cooperation and respect, positivity, lightening others' burdens, taking treatment seriously, recognizing mutual impact, communication, and acknowledging mortality. Of 589 interview phrases, 184 (31%) depicted themes of care for others and 58 (10%) spoke of tolerating treatment in the hope of a better future for one's self or others. The benefits and challenges of living up to these definitions were discussed.CONCLUSIONSClinicians may consider asking adolescents about their “good child” and “good patient” descriptions to learn more about the perceived roles carried by adolescents with cancer and how these roles may impact their decision making, medication adherence, and social interactions. Cancer 2016;122:2224–33. © 2016 American Cancer Society.
The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia
Authors: Galloway‐Peña Jessica R. , Smith Daniel P. , Sahasrabhojane Pranoti , Ajami Nadim J. , Wadsworth W. Duncan , Daver Naval G. , Chemaly Roy F. , Marsh Lisa , Ghantoji Shashank S. , Pemmaraju Naveen , Garcia‐Manero Guillermo , Rezvani Katayoun , Alousi Amin M. , Wargo Jennifer A. , Shpall Elizabeth J. , Futreal Phillip A. , Guindani Michele , Petrosino Joseph F. , Kontoyiannis Dimitrios P. , Shelburne Samuel A. 
Published: May 2016

BACKGROUNDDespite increasing data on the impact of the microbiome on cancer, the dynamics and role of the microbiome in infection during therapy for acute myelogenous leukemia (AML) are unknown. Therefore, the authors sought to determine correlations between microbiome composition and infectious outcomes in patients with AML who were receiving induction chemotherapy (IC).METHODSBuccal and fecal specimens (478 samples) were collected twice weekly from 34 patients with AML who were undergoing IC. Oral and stool microbiomes were characterized by 16S ribosomal RNA V4 sequencing using an Illumina MiSeq system. Microbial diversity and genera composition were associated with clinical outcomes.RESULTSBaseline stool α‐diversity was significantly lower in patients who developed infections during IC compared with those who did not (P = .047). Significant decreases in both oral and stool microbial α‐diversity were observed over the course of IC, with a linear correlation between α‐diversity change at the 2 sites (P = .02). Loss of both oral and stool α‐diversity was associated significantly with the receipt of a carbapenem P < 0.001. Domination events by the majority of genera were transient (median duration, 1 sample), whereas the number of domination events by pathogenic genera increased significantly over the course of IC (P = .002). Moreover, patients who lost microbial diversity over the course of IC were significantly more likely to contract a microbiologically documented infection within the 90 days after IC neutrophil recovery (P = .04).CONCLUSIONSThe current data present the largest longitudinal analyses to date of oral and stool microbiomes in patients with AML and suggest that microbiome measurements could assist with the mitigation of infectious complications of AML therapy. Cancer 2016;122:2186–96. © 2016 American Cancer Society.