bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards more sustainable, nutritious, and affordable plant‐based milk alternatives: A critical review
Authors: Suryamiharja Anthony , Gong Xiping , Zhou Hualu 
Published: September 2024

AbstractThe consumer market has seen a surge in various types of plant‐based milk alternatives (PBMAs), driven by factors such as sustainability, ethics, and the availability of diverse options. However, the global adoption of PBMAs is still hindered by potential nutritional concerns and cost‐ineffectiveness. It is therefore paramount to understand the status and challenges of these alternatives, encompassing production, stabilization strategies, nutrition and health, digestion, and environmental impacts. This review provides a comprehensive examination of these aspects. We begin by scrutinizing the production processes and formulation strategies of PBMAs, followed by an exploration of fundamental stabilization aspects, including homogenization, emulsification, thickening, and quantitative measurements of stabilization. Additionally, we discuss their nutrition facts and potential health benefits, as well as potential differences in the digestion of nutrients from PBMAs. Importantly, their challenges and future directions are discussed individually, highlighting the need for a fundamental understanding and effective food technologies to develop sustainable, nutritious, tasty, and affordable PBMAs. For example, several critical aspects involve maximizing the use of plant materials (e.g., proteins, fibers, and bioactive compounds) and using reliable and unified life cycle analyses to guide the development. This review offers valuable insights for researchers, food technologists, and consumers seeking to navigate and develop the landscape of PBMAs effectively.
Design, Synthesis, Molecular Docking, and in vitro Cytotoxicity Studies of Marine Natural Product Herdmanine Derivatives as Multitarget Inhibitor for EGFR and HER2 Breast Cancer Proteins
Authors: Gunjan  , Kumar Pradeep , Goel Nikita , Ganjoo Samarth , Yadav Monika , Verma Anita Kamra , Bhagat Sunita 
Published: September 2024

AbstractBreast cancer is a potentially deadly disease that affects millions of individuals worldwide. Therefore, it is crucial to design highly targeted therapeutic techniques with low toxicity. In this work, we synthesized natural product Herdmanine's ester derivatives and tested them against EGFR and HER2 proteins as multitargated inhibitor of breast cancer progression. Further, the newly synthesized compounds were evaluated for cytotoxicity against breast cancer cell lines MCF‐7, MDA‐MB‐231 and MDA‐MB‐157 and the biocompatibility towards NIH 3T3 cells. Higher toxicity and positive viability profiles of Herdmanine derivatives indicate their potential use for further exploration in breast cancer application.
Biodegradation Behaviour of the Composite Consisting of Polypropylene and Bauhinia Vahlii Fiber
Authors: Ray Rashmi , Das SankarNarayan 
Published: September 2024

AbstractThe current study focuses on the degradation rate of polypropylene (PP) and Bauhinia Vahlii (BV) fibers under soil burial and natural weathering conditions for 360 days. The BV‐PP composite was produced with varying BV fiber compositions (0, 10, 20, and 30 wt.%) and 3 % MAPP (Maleic Anhydride Grafted Polypropylene). In addition, MAPP is employed as a coupling agent to improve fiber‐matrix compatibility and promote degradation. The XRD examination shows that a 10 % BV‐PP composite has a crystallinity index of 52.05 %, which is higher than that of neat PP. The rate of biodegradability was investigated using weight loss and tensile properties. The largest degradation was seen in natural weathering conditions with 30 % composite showing the maximum weight loss of 3.8 % and loss in tensile strength and modulus of 16.76 % and 5.11 %, respectively. Simultaneously, no weight loss or drop in tensile characteristics was found in the case of neat PP over 360 days. The SEM images of soil burial show material deterioration, which may be aided by bacterial and fungal activity, whereas natural weathering conditions show a large crack, rougher fracture surface, and cavities, which are attributed to thermal stresses, changes in moisture content, and ultraviolet radiation, thereby promoting the degradation process.
Facile and Scalable Synthesis of Tripeptides with a Pro‐Pro Scaffold at C‐end: A TAG Approach
Authors: Nagaraja Akshitha D. , Avula Veeranjaneyulu , Lalithamba H. S. , Rao H. Surya Prakash , Govindappa Nagendra 
Published: September 2024

AbstractThe Pro‐Pro ligated tripeptides Ile‐Pro‐Pro 4 (IPP) and Val‐Pro‐Pro 5 (VPP) isolated from the fermented milk exhibit marked anti‐hypertension activity. Additionally, the naturally occurring Pro‐Pro ligated tripeptide Gly‐Pro‐Pro 6 (GPP) exhibits antioxidant properties. These peptides have enormous potential to be used as dilatory supplements. In the present study, we achieved a scalable, convenient, and high‐yielding synthesis of IPP, VPP, and GPP along with two more hydrophobic Pro‐Pro ligated tripeptides (APP 7, LPP 8) by employing the TAG technique. We used acid labile (2,4‐bis(octadecyloxy)phenyl)methanol as the TAG. We demonstrated synthesis of one of IPP at molar scale. We think that our method has the potential to be escalated to an industrial scale without much difficulty and they become available for general use as dietary supplements.
Metal‐Supported Heterogeneous Catalysts for the Synthesis of Nitrogen‐Containing Heterocycles: A Comprehensive Review
Authors: Damera Thirupathi , Naga Gayatri Sambhani , Pagadala Ramakanth , Abbu Venugopal , Palle Kishor , Gullapelli Kumaraswamy 
Published: September 2024

AbstractThe use of metals in the preparation of heterocycles has become increasingly popular due to several key advantages of metals as catalysts. These include recycling capability, eco‐friendliness, simplicity of catalyst preparation and separation, longer lifespan, abundance, and higher yields. As a result of their novel applications in organic, inorganic, medicinal, industrial, polymer chemistry, material sciences, nanotechnology, and biological processes, the utilization of nitrogen‐containing heterocycles has rapidly increased in recent years. Various nitrogen‐containing organic moieties are used in therapeutic processes to enhance effectiveness against several bacterial and viral diseases. This review covers the preparation of imidazoles, triazoles, tetrazoles, pyridine derivatives, azo compounds, pyrimidines, quinoxalines, and quinolines using metals as heterogeneous catalysts. It provides an overview of current methodologies for metal‐assisted heterogeneous catalytic reactions, including product yield, operating temperature, and solvents, among other factors. Heterogeneous catalyst‐mediated organic synthetic reactions offer several advantages, particularly in medicinal chemistry, pharmaceuticals, and industrial applications, by reducing time and energy consumption. This review emphasizes recent advancements in the fabrication of nitrogen heterocycles utilizing heterogeneous catalysts, taking into account various economic, eco‐friendly, and user‐friendly considerations. Additionally, it discusses the benefits, reaction conditions, and yields reported in the literature over the past six years.
Design and Synthesis of New Aminothiazole‐Benzazole Based Ureas: Antiproliferative and Antimigration Activity Studies
Authors: Arslan Gülnur , Erzurumlu Yalçın , Muhammed Muhammed Tilahun , Özçelik Azime Berna 
Published: September 2024

AbstractIn our quest to develop new treatments for cancer, we synthesized and tested a series of urea‐functionalized aminothiazole‐benzazole analogs. Our primary focus was assessing their ability to inhibit the growth of breast cancer (MCF‐7) and lung adenocarcinoma (A549) cells. Using 1H NMR, 13C NMR spectra, and high resolution mass spectrometry (HRMS), we confirmed the chemical structures of these compounds. Among them, compound 8a demonstrated significant cytotoxicity against MCF‐7 cells, achieving an IC50 value of 9.6±0.6 μM. Similarly, compound 8e exhibited potent cytotoxicity against A549 cells, with an IC50 value of 9.2±1.1 μM. We further investigated the antimigration properties of all compounds that showed promising antiproliferative effects in both MCF‐7 and A549 cells. Additionally, we evaluated how these compounds impact key apoptosis‐related proteins: Caspase‐7, PARP‐1, BAX, and Bcl‐2. These proteins play crucial roles in the regulation of programmed cell death. Overall, our findings suggest that these urea‐functionalized aminothiazole‐benzazole analogs hold promise as potential anticancer agents, warranting further exploration into their mechanisms of action and therapeutic potential.
Strategy of Nutrient Recovery from Domestic Wastewater Using Magnesium‐Modified Agricultural‐Waste‐Based Biochars
Authors: Tien Pham Duc , Minh Hoang Trang , Ngoc Truong Minh , Van Dang Thanh , Thi Minh Tran Hang , Van der Bruggen Bart , Manh Nguyen Khai 
Published: September 2024

AbstractThis work presents a reasonable strategy of optimizing the N : P molar ratio of municipal wastewater to simultaneously restore N‐NH4+ and P‐PO43− via struvite precipitation employing biochar modified with magnesium as the seeding material. The phosphate removal efficiency and ammonium removal efficiency could reach up to 71 % and 100 %, respectively. The remaining phosphate can be restored by other techniques for low phosphate concentration input, such as electrocoagulation. The XRD patterns indicate the appearance of struvite with high nutrient contents including Mg, N and P in the resulting precipitate, suggesting its potential agricultural application. The biochar from rice husk and rice straw modified with MgCl2 solution via a simple procedure could be used as a new seeding material in struvite precipitation to simultaneously restore phosphate and ammonium from wastewater. It has been found that modifying with MgCl2 concentration of 0.5 M and 1 M were enough to improve 14.7 % and 26.5 % of the phosphate removal efficiencies of rice straw‐based and rice husk‐based biochar, respectively. Along with the highly compatible of the post‐precipitated product with soil amendment, the magnesium modified biochars from rice husk and rice straw were highly suitable for enhancing the restoration of phosphate and ammonium via struvite precipitation.
Novel Efficient and Eco‐Friendly Biosorbent Derived from Ditax (Detarium senegalense) Fruit Hulls for Removal of Cationic Dyes: Adsorption Modeling and Statistical Optimization
Authors: Tcheka Constant , Salatou Nen‐Oure Benedicte , Alifa Tchigo , Marianne Conradie Marrigje , Conradie Jeanet 
Published: September 2024

AbstractRemediation of wastewater laden with dyes using optimized and less expensive techniques remains a challenge for environmental protection. In the current research work, alkaline activation approach was employed to derive a biosorbent from ditax fruit hulls (DS‐FHB), and its sorption performance was tested on Methylene blue (MB) dye biosorption with optimizing adsorption parameters. Structural and chemical properties of DS‐FHB including crystallinity, morphology, and surface functionality were analysed using XRD, SEM, FTIR technics, and pHPZC determination. Optimization of adsorption parameters using a centered composite design (CCD) from response surface methodology led to achieving a peak dye removal rate of 98.97 %. The optimal conditions were determined as DS‐FHB mass of 0.23 g, pH 7.12, contact time 39.00 min, and initial MB concentration of 69.35 mg/L. The findings demonstrated a strong alignment with both the Langmuir isotherm and pseudo‐second order kinetic model, suggesting their appropriateness in describing the adsorption process of MB onto DS‐FHB. According to the Langmuir isotherm model, the sorption of MB dye onto DS‐FHB occurred by monolayer formation with a maximum dye sorption capacity of 96.453 mg/g. Based on the structural and physico‐chemical properties of DS‐FHB biosorbent, and its adsoption applicability evaluated in the experimental conditions, detax derived‐biosorbent can be proposed as a successful and effective low‐cost biosorbent for removing cationic dyestuffs from aqueous solutions.
Tin‐Lead Perovskite Solar Cells with Preferred Crystal Orientation by Buried Interface Approach
Authors: Xiong Jiaxing , Wang Qiuxiang , Xing Yanjun , Gan Xinlei , Zhu Wendong , Xuan Rong , Huang Like , Liu Xiaohui , Zhu Yuejin , Zhang Jing 
Published: September 2024

AbstractMixed tin‐lead perovskite solar cells (PSCs) have garnered much attention for their ideal bandgap and high environmental research value. However, poly (3,4‐ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS), widely used as a hole transport layer (HTL) for Sn‐Pb PSCs, results in unsatisfactory power conversion efficiency (PCE) and long‐term stability of PSCs due to its acidity and moisture absorption. A synergistic strategy by incorporating histidine (HIS) into the PEDOT: PSS HTL is applied to simultaneously regulate the nucleation and crystallization of perovskite (PVK). HIS neutralizes the acidity of PEDOT: PSS and enhances conductivity. Especially, the coordination of the C═N and ‐COO− functional groups in the HIS molecule with Sn2+ and Pb2+ induces vertical growth of PVK film, resulting in the release of residual surface stress. Additionally, this strategy also optimizes the energy level alignment between the perovskite layer and the HTL, which improves charge extraction and transport. With these cooperative effects, the PCE of Sn‐Pb PSCs reaches 21.46% (1 sun, AM1.5), maintaining excellent stability under a nitrogen atmosphere. Hence, the buried interface approach exhibits the potential for achieving high‐performance and stable Sn‐Pb PSCs.
Bimetallic Sulfur‐Doped Nickel–Cobalt Selenides as Efficient Bifunctional Electrocatalysts for the Complete Decomposition of Water
Authors: Luo ZhongKe , Yi Hao , Yang ZiHan , Wang Chao 
Published: September 2024

AbstractThe creation and enhancement of non‐precious metal bifunctional catalysts with superior stability and stabilizing activity is necessary to achieve water splitting in alkaline media. The paper presents a method for preparing nickel–cobalt bimetallic selenides (NiCo‐Sex/CF) using a combination of hydrothermal and high‐temperature selenization techniques. NiCo‐Sex/CF shows great potential as a catalyst for water separation. The catalyst's electronic structure and active centre can be modified by double doping with sulfur and selenium, resulting in increased selectivity and activity under varying reaction conditions. This method also offers the benefits of a simple preparation process and applicability to a wide range of catalytic reactions. Experimental results demonstrate that an overpotential of 194 mV produces a current density of 10 mA cm−2 when using this electrocatalyst as an OER catalyst. When used as a HER catalyst, the electrocatalyst required an overpotential of only 76 mV to generate a current density of 10 mA cm−2.Furthermore, a voltage of 1.5 V can drive the overall decomposition of water to achieve a current density of 10 mA cm−2. This study highlights the potential of sulfur‐selenide double‐doped catalysts for both scientific research and practical applications.
Cathodoluminescent and Characteristic X‐Ray‐Emissive Rare‐Earth‐Doped Core/Shell Protein Labels for Spectromicroscopic Analysis of Cell Surface Receptors
Authors: Habermann Sebastian , Gerken Lukas R. H. , Kociak Mathieu , Monachon Christian , Kissling Vera M. , Gogos Alexander , Herrmann Inge K. 
Published: September 2024

AbstractUnderstanding the localization and the interactions of biomolecules at the nanoscale and in the cellular context remains challenging. Electron microscopy (EM), unlike light‐based microscopy, gives access to the cellular ultrastructure yet results in grey‐scale images and averts unambiguous (co‐)localization of biomolecules. Multimodal nanoparticle‐based protein labels for correlative cathodoluminescence electron microscopy (CCLEM) and energy‐dispersive X‐ray spectromicroscopy (EDX‐SM) are presented. The single‐particle STEM‐cathodoluminescence (CL) and characteristic X‐ray emissivity of sub‐20 nm lanthanide‐doped nanoparticles are exploited as unique spectral fingerprints for precise label localization and identification. To maximize the nanoparticle brightness, lanthanides are incorporated in a low‐phonon host lattice and separated from the environment using a passivating shell. The core/shell nanoparticles are then functionalized with either folic (terbium‐doped) or caffeic acid (europium‐doped). Their potential for (protein‐)labeling is successfully demonstrated using HeLa cells expressing different surface receptors that bind to folic or caffeic acid, respectively. Both particle populations show single‐particle CL emission along with a distinctive energy‐dispersive X‐ray signal, with the latter enabling color‐based localization of receptors within swift imaging times well below 2 min per 2 while offering high resolution with a pixel size of 2.78 nm. Taken together, these results open a route to multi‐color labeling based on electron spectromicroscopy.
Periodic Flows in Microfluidics
Authors: Mudugamuwa Amith , Roshan Uditha , Hettiarachchi Samith , Cha Haotian , Musharaf Hafiz , Kang Xiaoyue , Trinh Quang Thang , Xia Huan Ming , Nguyen Nam‐Trung , Zhang Jun 
Published: September 2024

AbstractMicrofluidics, the science and technology of manipulating fluids in microscale channels, offers numerous advantages, such as low energy consumption, compact device size, precise control, fast reaction, and enhanced portability. These benefits have led to applications in biomedical assays, disease diagnostics, drug discovery, neuroscience, and so on. Fluid flow within microfluidic channels is typically in the laminar flow region, which is characterized by low Reynolds numbers but brings the challenge of efficient mixing of fluids. Periodic flows are time‐dependent fluid flows, featuring repetitive patterns that can significantly improve fluid mixing and extend the effective length of microchannels for submicron and nanoparticle manipulation. Besides, periodic flow is crucial in organ‐on‐a‐chip (OoC) for accurately modeling physiological processes, advancing disease understanding, drug development, and personalized medicine. Various techniques for generating periodic flows have been reported, including syringe pumps, peristalsis, and actuation based on electric, magnetic, acoustic, mechanical, pneumatic, and fluidic forces, yet comprehensive reviews on this topic remain limited. This paper aims to provide a comprehensive review of periodic flows in microfluidics, from fundamental mechanisms to generation techniques and applications. The challenges and future perspectives are also discussed to exploit the potential of periodic flows in microfluidics.
Dual‐Mode MXene‐Based Phase‐Change Composite Towards Enhanced Photothermal Utilization and Excellent Infrared Stealth
Authors: Zhu Xinbei , Liu Jingkai , Zhang Liyue , Zhao Weiwei , Cao Yiyu , Liu Xiaoqing 
Published: September 2024

AbstractSolar thermal collectors based on phase change materials (PCMs) are important to promote the civilian use of sustainable energy. However, simultaneously achieving high photothermal efficiency and rapid heat transfer of the PCM carrier typically involves a high proportion of functional materials, contradicting a satisfying energy storage density. In this work, a surface‐engineered anisotropic MXene‐based aerogel (LMXA) integrated with myristic acid (MA) to produce phase change composites (LMXA‐MA) is reported, in which the laser‐treated surface composed of the hierarchically‐structured TiO2/carbon composites act as a light absorber to improve solar absorption (96.0%), while the vertical through‐hole structure allows for fast thermal energy transportation from surface to the whole. As a result, LMXA‐MA exhibits outstanding thermal energy storage (192.4 J·g−1) and high photothermal conversion efficiency (93.5%). Meanwhile, benefiting from the intrinsic low emissivity of MXene material, thermal radiation loss can be effectively suppressed by simply flipping LMXA‐MA, enabling a long‐term temperature control ability (605 s·g−1). The excellent heat storage property and switchable dual‐mode also endow it with an infrared stealth function, which maintains camouflage for more than 240 s. This work provides a prospective solution for optimizing photothermal conversion efficiency and long‐term thermal energy preservation from surface engineering and structural design.
AI‐Equipped Scanning Probe Microscopy for Autonomous Site‐Specific Atomic‐Level Characterization at Room Temperature
Authors: Diao Zhuo , Ueda Keiichi , Hou Linfeng , Li Fengxuan , Yamashita Hayato , Abe Masayuki 
Published: September 2024

AbstractAn advanced scanning probe microscopy system enhanced with artificial intelligence (AI‐SPM) designed for self‐driving atomic‐scale measurements is presented. This system expertly identifies and manipulates atomic positions with high precision, autonomously performing tasks such as spectroscopic data acquisition and atomic adjustment. An outstanding feature of AI‐SPM is its ability to detect and adapt to surface defects, targeting or avoiding them as necessary. It is also designed to overcome typical challenges such as positional drift and tip apex atomic variations due to the thermal effects, ensuring accurate, site‐specific surface analysis. The tests under the demanding conditions of room temperature have demonstrated the robustness of the system, successfully navigating thermal drift and tip fluctuations. During these tests on the Si(111)‐(7 × 7) surface, AI‐SPM autonomously identified defect‐free regions and performed a large number of current–voltage spectroscopy measurements at different adatom sites, while autonomously compensating for thermal drift and monitoring probe health. These experiments produce extensive data sets that are critical for reliable materials characterization and demonstrate the potential of AI‐SPM to significantly improve data acquisition. The integration of AI into SPM technologies represents a step toward more effective, precise and reliable atomic‐level surface analysis, revolutionizing materials characterization methods.
A robust antagonistically assembled triboelectric nanogenerator based on dead‐end closed pore through a one‐step improved phase separation
Authors: Chau Ngoc Mai , Hoang Gia Huy Nguyen , Huynh Dai Phu , Cao Xuan Viet , La Thi Thai Ha , Bui Van‐Tien 
Published: September 2024

AbstractThe ongoing global energy crisis presents a significant challenge all over the world. In this study, triboelectric nanogenerator (TENG) made of recyclable thermoplastic polycarbonate has been proposed as a promising environmentally friendly solution due to its potential capability to convert low‐frequency mechanical energy sources such as human motion and ocean waves into electricity with potential applications including powering wearable electronic devices and self‐powered sensors. We introduce an antagonistically structured TENG (A‐TENG) composed of honeycomb porous polycarbonate (hc‐PC) and convex‐patterned dimethylsiloxane, employing a novel one‐stage improved phase separation method. This A‐TENG overcomes the demerits of others thanks to its high surface contact area, simplified fabrication process, enhanced energy conversion efficiency, and cost‐effectiveness, requiring minimal investment. More importantly, this work utilized hc‐PC as a framework for slippery liquid‐infused porous surface (SLIPS) based TENG owing to the special honeycomb porous structure to impregnate silicon oil within pore arrays and mechanically support the whole system. The practical application of SLIPS‐TENG was demonstrated while deployed on the house rooftop to harvest raindrop energy and act as a rain detection sensor.