bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Body Wraps in Swiss public adult acute inpatient wards. A retrospective descriptive cohort study
Authors: Opsommer E. , Dubois J. , Bangerter G. , Panchaud R. , Martin D. , Skuza K. 
Published: April 2016

Accessible summaryWhat is known on the subject?

Various expert opinions reported relational benefits and tranquilizing effects of therapeutic body wraps (TBW) in adults experiencing high anxiety in the context of psychosis. Yet, this tranquilizing effect was never investigated in larger samples and in the context of modern psychopharmacology.

What this paper adds to existing knowledge?

This is the first study to establish descriptive statistics of this mind‐body therapy in French‐speaking Switzerland where TBWs are routinely used in two public psychiatric hospitals. It brings knowledge on patients nowadays treated with TBW. Moreover, it opens a new area of investigation on the potential of this nursing technique, which may contribute to reduce anxiolytic medication in severely ill patients.

What are the implications for practice?

This study sheds light on a clinical practice in mental health nursing and upon nurses’ specific contribution to psychiatric clinic. It investigates a potential for TBWs to reduce the use of anxiolytic medications by patients who agreed to have TBW as part of their treatment. It may help to inform the mental health nursing practice.

AbstractIntroductionMany patients suffering from serious mental illness experience severe anxiety and those with psychosis often report the feeling of their bodies falling apart. While it is believed that these patients benefit from therapeutic body wraps (TBWs), the use of this adjunct therapy has rarely been studied in adult patients.AimsThe aim of this study was to obtain descriptive statistics on the clinical, social‐demographic and institutional reality of TBW therapy in Swiss public adult inpatient wards.MethodsRetrospective data related to a cohort of 172 adult inpatients were retrieved from records of two public hospitals. Correlations between TBW and the prescriptions of lorazepam were explored.ResultsTBWs were primarily used for patients diagnosed with either schizophrenia, schizotypal, delusional and other non‐mood psychotic disorders or mood disorders. Patients had, on average, four psychiatric hospitalizations, and in 30% of the cases, TBWs were offered during the first hospitalization. Moreover, TBWs were mostly practiced by nurses. Body wraps were potentially associated with a reduction in both anxiolytic and neuroleptic drugs.Discussion/Implication for practiceBased on our results, TBW might contribute to the clinical management of anxiety by nurses. The efficacy of TWB regarding anxiety has yet to be investigated in a randomized controlled trial.
Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight
Authors: Yamamura‐Miyazaki Natsumi , Yamamoto Katsusuke , Fujiwara Kaori , Santo Yoko , Michigami Toshimi , Kitajima Hiroyuki , Satomura Kenichi 
Published: April 2016

AbstractAimA single centre retrospective cohort study was designed to investigate the estimated glomerular filtration rate (eGFR) in school‐age children born with extremely low birthweight (ELBW) and to determine risk factors predictive of decreased eGFR.MethodsWe compared eGFR based on cystatin C (CysC‐eGFR) between school‐age children born with ELBW (ELBW group, n = 48; median gestational age: 26.9 weeks; median birthweight: 792 g) and children born at term (control group, n = 48). The ELBW group was then further divided into a decreased CysC‐eGFR subgroup (eGFR <90 mL/min per 1.73 m2, n = 20) and a normal CysC‐eGFR subgroup (n = 28), and perinatal background factors were compared.ResultsThe ELBW group showed a significantly lower CysC‐eGFR compared with the control group (P < 0.001). Comparison between the decreased and normal CysC‐eGFR subgroups in the ELBW group showed that children with lower birthweight, shorter gestational age, lower 5‐min Apgar score, longer length of mechanical ventilation, lower weight gain in the first 11 weeks, chronic lung disease, and postnatal corticosteroid administration had significantly decreased CysC‐eGFR. Multivariate logistic regression showed that a lower 5‐min Apgar score was the only independent risk factor for decreased CysC‐eGFR.ConclusionsCysC‐eGFR might already be decreased at school age in children born with ELBW. Renal assessment in regular follow‐up examinations is recommended.
Decomposing Beveridge Curve Dynamics By Correlated Unobserved Components
Authors: Klinger Sabine , Weber Enzo 
Published: April 2016

AbstractOur paper provides a consistent framework to study the structural or cyclical nature of Beveridge curve (BC) dynamics: We connect equilibrium unemployment theory to a flexible multivariate unobserved components model. We disentangle permanent and transitory components of all series determining the BC and its position. Cointegration and identification are addressed. The German curve is an ideal illustration as reforms of the institutional setting and the Great Recession were accompanied by a remarkable labour market development. We find an extraordinary increase in trend matching efficiency after the reforms, which testifies to a permanent improvement. Matching efficiency accounts for about half of the BCś inward shift. As tightness also increased, a persistent upward movement masked the inward shift.
Parenting and childhood obesity research: a quantitative content analysis of published research 2009–2015
Authors: Gicevic S. , Aftosmes‐Tobio A. , Manganello J. A. , Ganter C. , Simon C. L. , Newlan S. , Davison K. K. 
Published: April 2016

SummaryBackgroundA quantitative content analysis of research on parenting and childhood obesity was conducted to describe the recent literature and to identify gaps to address in future research.MethodsStudies were identified from multiple databases and screened according to an a priori defined protocol. Eligible studies included non‐intervention studies, published in English (January 2009–December 2015) that focused on parenting and childhood obesity and included parent participants.ResultsStudies eligible for inclusion (N = 667) focused on diet (57%), physical activity (23%) and sedentary behaviours (12%). The vast majority of studies used quantitative methods (80%) and a cross‐sectional design (86%). Few studies focused exclusively on fathers (1%) or included non‐residential (1%), non‐biological (4%), indigenous (1%), immigrant (7%), ethnic/racial minority (15%) or low‐socioeconomic status (19%) parents.DiscussionWhile results illustrate that parenting in the context of childhood obesity is a robust, global and multidisciplinary area of inquiry, it is also evident that the vast majority of studies are conducted among Caucasian, female, biological caregivers living in westernized countries. Expansion of study foci and design is recommended to capture a wider range of caregiver types and obesity‐related parenting constructs, improve the validity and generalizability of findings and inform the development of culture‐specific childhood obesity prevention interventions and policies. © 2016 World Obesity
The action model of relationship security: How one's own behavior shapes confidence in partners' care, regard, and commitment
Authors: LEMAY EDWARD P. , MUIR HEATHER J. 
Published: April 2016

AbstractThe authors present and test the action model of relationship security, which predicts that people's behavior toward a relationship partner shapes their security regarding that partner's care, regard, and commitment. Specifically, actors who enact prosocial or antisocial behavior develop corresponding prosocial or antisocial metaperceptions (i.e., they believe they are viewed as prosocial or antisocial by their partner). In turn, these metaperceptions have a strong influence on actors' security in their partner's care, regard, and commitment due to lay theories positing that prosocial and antisocial behavior impacts others' sentiments. Four studies supported this model. Moreover, findings suggest that prosocial metaperceptions buffer the harmful effects of attachment anxiety on relationship security. This research suggests the relevance of own behavior for relationship security.
Mechanisms Involved in Acquisition of
bla
NDM
Genes by IncA/C
2
and IncFII
Y
Plasmids
Authors: Wailan Alexander M. , Sidjabat Hanna E. , Yam Wan Keat , Alikhan Nabil-Fareed , Petty Nicola K. , Sartor Anna L. , Williamson Deborah A. , Forde Brian M. , Schembri Mark A. , Beatson Scott A. , Paterson David L. , Walsh Timothy R. , Partridge Sally R. 
Published: April 2016

ABSTRACT

bla
NDM
genes confer carbapenem resistance and have been identified on transferable plasmids belonging to different incompatibility (Inc) groups. Here we present the complete sequences of four plasmids carrying a
bla
NDM
gene, pKP1-NDM-1, pEC2-NDM-3, pECL3-NDM-1, and pEC4-NDM-6, from four clinical samples originating from four different patients. Different plasmids carry segments that align to different parts of the
bla
NDM
region found on
Acinetobacter
plasmids. pKP1-NDM-1 and pEC2-NDM-3, from
Klebsiella pneumoniae
and
Escherichia coli
, respectively, were identified as type 1 IncA/C
2
plasmids with almost identical backbones. Different regions carrying
bla
NDM
are inserted in different locations in the antibiotic resistance island known as ARI-A, and IS
CR1
may have been involved in the acquisition of
bla
NDM-3
by pEC2-NDM-3. pECL3-NDM-1 and pEC4-NDM-6, from
Enterobacter cloacae
and
E. coli
, respectively, have similar IncFII
Y
backbones, but different regions carrying
bla
NDM
are found in different locations. Tn
3
-derived inverted-repeat transposable elements (TIME) appear to have been involved in the acquisition of
bla
NDM-6
by pEC4-NDM-6 and the
rmtC
16S rRNA methylase gene by IncFII
Y
plasmids. Characterization of these plasmids further demonstrates that even very closely related plasmids may have acquired
bla
NDM
genes by different mechanisms. These findings also illustrate the complex relationships between antimicrobial resistance genes, transposable elements, and plasmids and provide insights into the possible routes for transmission of
bla
NDM
genes among species of the
Enterobacteriaceae
family.
Molecular Diversity and Plasmid Analysis of KPC-Producing Escherichia coli
Authors: Chavda Kalyan D. , Chen Liang , Jacobs Michael R. , Bonomo Robert A. , Kreiswirth Barry N. 
Published: April 2016

ABSTRACT

The emergence and spread of
Klebsiella pneumoniae
carbapenemase (KPC) among
Enterobacteriaceae
presents a major public health threat to the world. Although not as common as in
K. pneumoniae
, KPC is also found in
Escherichia coli
strains. Here, we genetically characterized 9 carbapenem-resistant
E. coli
strains isolated from six hospitals in the United States and completely sequenced their
bla
KPC
-harboring plasmids. The nine strains were isolated from different geographical locations and belonged to 8 different
E. coli
sequence types. Seven
bla
KPC
-harboring plasmids belonged to four different known incompatibility groups (IncN, -FIA, -FII
K2
, and -FII
K1
) and ranged in size from ∼16 kb to ∼241 kb. In this analysis, we also identified two plasmids that have novel replicons: (i) pBK28610, which is similar to p34978-3 with an insertion of Tn
4401b
, and (ii) pBK31611, which does not have an apparent homologue in the GenBank database. Moreover, we report the emergence of a pKP048-like plasmid, pBK34397, in
E. coli
in the United States. Meanwhile, we also found examples of interspecies spread of
bla
KPC
plasmids, as pBK34592 is identical to pBK30683, isolated from
K. pneumoniae
. In addition, we discovered examples of acquisition (pBK32602 acquired an ∼46-kb fragment including a novel replication gene, along with Tn
4401b
and other resistance genes) and/or loss (pKpQIL-Ec has a 14.5-kb deletion compared to pKpQIL-10 and pBK33689) of DNA, demonstrating the plasticity of these plasmids and their rapid evolution in the clinic. Overall, our study shows that the spread of
bla
KPC
-producing
E. coli
is largely due to horizontal transfer of
bla
KPC
-harboring plasmids and related mobile elements into diverse genetic backgrounds.
In Vivo
and
In Vitro
Efficacy of Minocycline-Based Combination Therapy for Minocycline-Resistant Acinetobacter baumannii
Authors: Yang Ya-Sung , Lee Yi , Tseng Kuo-Chuan , Huang Wei-Cheng , Chuang Ming-Fen , Kuo Shu-Chen , Lauderdale Tsai-Ling Yang , Chen Te-Li 
Published: April 2016

ABSTRACT

Minocycline-based combination therapy has been suggested to be a possible choice for the treatment of infections caused by minocycline-susceptible
Acinetobacter baumannii
, but its use for the treatment of infections caused by minocycline-resistant
A. baumannii
is not well established. In this study, we compared the efficacy of minocycline-based combination therapy (with colistin, cefoperazone-sulbactam, or meropenem) to that of colistin in combination with meropenem for the treatment of minocycline-resistant
A. baumannii
infection. From 2006 to 2010, 191 (17.6%) of 1,083
A. baumannii
complex isolates not susceptible to minocycline from the Taiwan Surveillance of Antimicrobial Resistance program were collected. Four representative
A. baumannii
isolates resistant to minocycline, amikacin, ampicillin-sulbactam, ceftazidime, ciprofloxacin, cefepime, gentamicin, imipenem, levofloxacin, meropenem, and piperacillin-tazobactam were selected on the basis of the diversity of their pulsotypes, collection years, health care setting origins, and geographic areas of origination. All four isolates had
tetB
and overexpressed
adeABC
, as revealed by quantitative reverse transcription-PCR. Among all minocycline-based regimens, only the combination with colistin produced a fractional inhibitory concentration index comparable to that achieved with meropenem combined with colistin. Minocycline (4 or 16 μg/ml) in combination with colistin (0.5 μg/ml) also synergistically killed minocycline-resistant isolates in time-kill studies. Minocycline (50 mg/kg of body weight) in combination with colistin (10 mg/kg) significantly improved the survival of mice and reduced the number of bacteria present in the lungs of mice compared to the results of monotherapy. However, minocycline (16 μg/ml)-based therapy was not effective at reducing biofilm-associated bacteria at 24 or 48 h when its effectiveness was compared to that of colistin (0.5 μg/ml) and meropenem (8 μg/ml). The clinical use of minocycline in combination with colistin for the treatment of minocycline-resistant
A. baumannii
may warrant further investigation.
Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces
Authors: Haisma Elisabeth M. , Göblyös Anikó , Ravensbergen Bep , Adriaans Alwin E. , Cordfunke Robert A. , Schrumpf Jasmijn , Limpens Ronald W. A. L. , Schimmel Kirsten J. M. , den Hartigh Jan , Hiemstra Pieter S. , Drijfhout Jan Wouter , El Ghalbzouri Abdoelwaheb , Nibbering Peter H. 
Published: April 2016

ABSTRACT

We previously found the LL-37-derived peptide P60.4Ac to be effective against methicillin-resistant
Staphylococcus aureus
(MRSA) on human epidermal models (EMs). The goal of this study was to identify the preferred carrier for this peptide for topical application on skin and mucosal surfaces. We prepared P60.4Ac in three formulations, i.e., a water-in-oil cream with lanolin (Softisan 649), an oil-in-water cream with polyethylene glycol hexadecyl ether (Cetomacrogol), and a hydroxypropyl methylcellulose (hypromellose) 4000 gel. We tested the antimicrobial efficacy of the peptide in these formulations against mupirocin-resistant and -sensitive MRSA strains on EMs and bronchial epithelial models (BEMs). The cytotoxic effects of formulated P60.4Ac on these models were determined using histology and WST-1 and lactate dehydrogenase assays. Moreover, we assessed the stability of the peptide in these formulations with storage for up to 3 months. Killing of MRSA by P60.4Ac in the two creams was less effective than that by P60.4Ac in the hypromellose gel. In agreement with those findings, P60.4Ac in the hypromellose gel was highly effective in eradicating the two MRSA strains from EMs. We found that even 0.1% (wt/wt) P60.4Ac in the hypromellose gel killed >99% of the viable planktonic bacteria and >85% of the biofilm-associated bacteria on EMs. Hypromellose gels containing 0.1% and 0.5% (wt/wt) P60.4Ac effectively reduced the numbers of viable MRSA cells from BEMs by >90%. No cytotoxic effects of P60.4Ac in the hypromellose gel with up to 2% (wt/wt) P60.4Ac on keratinocytes in EMs and in the hypromellose gel with up to 0.5% (wt/wt) P60.4Ac on epithelial cells in BEMs were observed. High-performance liquid chromatography analysis showed that P60.4Ac was stable in the Softisan cream and the hypromellose gel but not in the Cetomacrogol cream. We conclude that P60.4Ac formulated in hypromellose gel is both stable and highly effective in eradicating MRSA from colonized EMs and BEMs.
Limits of Versatility of Versatile Peroxidase
Authors: Knop Doriv , Levinson Dana , Makovitzki Arik , Agami Avi , Lerer Elad , Mimran Avishai , Yarden Oded , Hadar Yitzhak 
Published: April 2016

ABSTRACT

Although Mn
2+
is the most abundant substrate of versatile peroxidases (VPs), repression of
Pleurotus ostreatus
vp1
expression occurred in Mn
2+
-sufficient medium. This seems to be a biological contradiction. The aim of this study was to explore the mechanism of direct oxidation by VP1 under Mn
2+
-deficient conditions, as it was found to be the predominant enzyme during fungal growth in the presence of synthetic and natural substrates. The native VP1 was purified and characterized using three substrates, Mn
2+
, Orange II (OII), and Reactive Black 5 (RB5), each oxidized by a different active site in the enzyme. While the pH optimum for Mn
2+
oxidation is 5, the optimum pH for direct oxidation of both dyes was found to be 3. Indeed, effective
in vivo
decolorization occurred in media without addition of Mn
2+
only under acidic conditions. We have determined that Mn
2+
inhibits
in vitro
the direct oxidation of both OII and RB5 while RB5 stabilizes both Mn
2+
and OII oxidation. Furthermore, OII was found to inhibit the oxidation of both Mn
2+
and RB5. In addition, we could demonstrate that VP1 can cleave OII in two different modes. Under Mn
2+
-mediated oxidation conditions, VP1 was able to cleave the azo bond only in asymmetric mode, while under the optimum conditions for direct oxidation (absence of Mn
2+
at pH 3) both symmetric and asymmetric cleavages occurred. We concluded that the oxidation mechanism of aromatic compounds by VP1 is controlled by Mn
2+
and pH levels both in the growth medium and in the reaction mixture.

IMPORTANCE
VP1 is a member of the ligninolytic heme peroxidase gene family of the white rot fungus
Pleurotus ostreatus
and plays a fundamental role in biodegradation. This enzyme exhibits a versatile nature, as it can oxidize different substrates under altered environmental conditions. VPs are highly interesting enzymes due to the fact that they contain unique active sites that are responsible for direct oxidation of various aromatic compounds, including lignin, in addition to the well-known Mn
2+
binding active site. This study demonstrates the limits of versatility of
P. ostreatus
VP1, which harbors multiple active sites, exhibiting a broad range of enzymatic activities, but they perform differently under distinct conditions. The versatility of
P. ostreatus
and its enzymes is an advantageous factor in the fungal ability to adapt to changing environments. This trait expands the possibilities for the potential utilization of
P. ostreatus
and other white rot fungi.
Cost effectiveness of internet-based cognitive behaviour therapy and behavioural stress management for severe health anxiety
Authors: Hedman Erik , Andersson Erik , Ljótsson Brjánn , Axelsson Erland , Lekander Mats 
Published: April 2016

ObjectivesInternet-delivered exposure-based cognitive behaviour therapy (ICBT) has been shown to be effective in the treatment of severe health anxiety. The health economic effects of the treatment have, however, been insufficiently studied and no prior study has investigated the effect of ICBT compared with an active psychological treatment. The aim of the present study was to investigate the cost effectiveness of ICBT compared with internet-delivered behavioural stress management (IBSM) for adults with severe health anxiety defined as Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) hypochondriasis. ICBT was hypothesised to be the more cost-effective treatment.SettingThis was a cost-effectiveness study within the context of a randomised controlled trial conducted in a primary care/university setting. Participants from all of Sweden could apply to participate.ParticipantsSelf-referred adults (N=158) with a principal diagnosis of DSM-IV hypochondriasis, of whom 151 (96%) provided baseline and post-treatment data.InterventionsICBT or IBSM for 12 weeks.Primary and secondary measuresThe primary outcome was the Health Anxiety Inventory. The secondary outcome was the EQ-5D. Other secondary measures were used in the main outcome study but were not relevant for the present health economic analysis.ResultsBoth treatments led to significant reductions in gross total costs, costs of healthcare visits, direct non-medical costs and costs of domestic work cutback (p=0.000–0.035). The incremental cost-effectiveness ratio (ICER) indicated that the cost of one additional case of clinically significant improvement in ICBT compared with IBSM was $2214. The cost-utility ICER, that is, the cost of one additional quality-adjusted life year, was estimated to be $10 000.ConclusionsICBT is a cost-effective treatment compared with IBSM and treatment costs are offset by societal net cost reductions in a short time. A cost-benefit analysis speaks for ICBT to play an important role in increasing access to effective treatment for severe health anxiety.Trial registration numberNCT01673035; Results.