bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revision of Failed Artroscopic Bankart Repairs
Authors: Muiño José María Silberberg , Gimenez Martín Alejandro , Salvucci Mauro Gabriel Maroa , Ferro Diego , Rullan Ramón Muiña 
Published: January 2017

Objectives: To present our functional outcomes from patients treated arthroscopically for a failed Bankart repair, using suture anchors and capsulolabral tissue only. Methods: Series of 22 patients presented with a recurrence of instability after a previous stabilization surgery (3 Latarjet, Bankart 19). We treated them by a an all-arthroscopic procedure, avoiding bone grafts, when glenoid track was found to be enough to proceed. The failure was associated with trauma in 11 patients, a non-anatomic repair in 6 patients, capsular laxity in 4 patients and a non-union of the coracoid graft in 1 patient. Revision surgery included: Bankart repair with anchors in 17 cases, a posterior-inferior capsulo-labral plication in one case, and 5 remplissages. In 4 cases subscapularis augmentation was used because of poor capsular quality. Screw removal was necessary when treating the non-union case. Patients were followed-up by a minimum of 23 months (range 23-26), and evaluated by the UCLA Test, SS test and Rowe score. Results: Thirteen patients had an excellent result, 6 good, 2 satisfactory and one bad result, according to UCLA score. The mean Rowe score was 90.4, at final follow up. The Simple Shoulder Test went from an 8 preoperative to an 11 postoperative, mean scores. 19 of 22 patients returned to the same level of activity prior to the injury. Complications: recurrence in 2 cases, subluxation in 2 and one shoulder stiffness that required an arthrolysis. Conclusion: An arthroscopic revision surgery, after a failed Bankart repair, presents satisfactory results in selected patients. Arthroscopic vision allows a correct diagnosis of injuries as possible causes of failure and subsequent treatment.
Comparison of the Clinical and Radiological Oucomes of Conventional Double row and Double row Suture Bridge Repairs in Rotator Cuff Tears
Authors: Muiño José María Silberberg , Gimenez Martín Alejandro , Salvucci Mauro Gabriel Maroa , Ferro Diego , Rullan Ramón Muiña , Blanchero Pablo 
Published: January 2017

Objectives: To compare clinical and radiological results of two types of rotator cuff (RC) repairs: the double row and double row-suture bridge. Methods: Forty-two patients with a complete tear (medium and large size) of the RC were repaired by a double row arthroscopic technique. Minimum follow-up was 19 months (range, 19-28 months). Clinical outcomes were assessed by the Modified Constant Scale and satisfaction rate by an independent observer; VAS, UCLA and ASES. Radiological results were assed by a postoperative MRI by a musculoskeletal radiologist. Results: Series of 22 patients in the double row technique (Group A) and 20 patients in the double-row suture bridge (Gruop B). Statistically there was a significant improvement in the Constant Scale, satisfaction rate, muscle assessment, VAS, UCLA and ASES in both groups after the surgical procedure. There were no significant clinical differences between both groups at any time after the surgical procedure. According to MRI postop, 19/22 shoulders in Group A and 18/20 in Group B remained intact, with no significant differences between the two groups. Conclusion: RC repairs with double row and double-row-suture bridge techniques provide clinical and radiological good and excelent results. In our retrospective, mid-size study, we have found no differences between these two repair techniques.
Lattisimus Dorsi Transfer assisted by arthroscopy for the treatment of irreparable posterolateral Rotator Cuff Tears
Authors: Muiño José María Silberberg , Gimenez Martín Alejandro , Salvucci Mauro Gabriel Maroa , Ferro Diego , Rullan Ramón Muiña 
Published: January 2017

Objective: To evaluate subjective and functional mid term results of patients treated by a lattisimus dorsi tendón transfer arthroscopically assisted for massive irreparable posterolateral injuries of the Rotator Cuff. Methods: Between 2009 and 2012, 17 Lattisimus Dorsi transfers (Paribelli technique) for irreparable posterolateral rotator cuff tears were performed. Distribution by sex: 12 men and 5 women with a mean age of 53 years old (range, 40-63). Thirteen right shoulders and 4 left shoulders. Average duration of symptoms prior to surgery was 8 months (range, 6-13 months). Mean follow-up was 28 months (range, 18-44). Patients were evaluated by the VAS, satisfaction rate, the Constant Modified Scale, postoperative range of motion and strength. Postoperative radiological studies included simple AP radiographs and MRI in order to measure AC distance and asses the integrity of the plasty. Results: Postoperative Constant Modified score averaged 63.54 points. (average increase of 13 points compared to preoperative score. (P ..05)). Active Mobility: a) Mean elevation: 142° postop vs. 119° preop (p <.001). b) Mean abduction: 138.24º postop vs. 112.35º preop (p <.001). c) Mean external rotation 40° postop vs. 20.29º preop (p <.004). Insert text. Conclusion: Lattisimus Dorsi transfer in patients with posterolateral massive irreparable injuries of the RC, is a highly demanding and palliative procedure for those cases with loss of active mobility, especially lifting and shoulder abduction.
Arthroscopic treatment of pincer-type femoroacetabular impingement performing acetabuloplasty without labral detachment
Authors: Comba Fernando , Slullitel Pablo , Bronenberg Pedro , Buttaro Martin , Zanotti Gerardo , Piccaluga Francisco 
Published: January 2017

Objectives: In order to access and resect the acetabular rim, arthroscopic acetabuloplasty was described with labral detachment. However, when the chondrolabral junction remains intact, acetabuloplasty and labral refixation can be performed maintaining an unharmed labrum. We aimed to evaluate the outcome of a group of patients treated with arthroscopic acetabuloplasty without labral detachment. Methods: During the study period, we retrospectively analyzed 44 patients with pincer-type o combined impingement and an intact chondroblabral junction, with an average followup of 32 months (range: 27-38). We excluded patients with CAM-type impingement and previous hip pathology. Radiographs were analyzed to define impingement and classify grade of osteoarthritis. Clinical evaluation consisted of preoperative and postoperative modified Harris Hip Score (mHHS) and WOMAC as well as postoperative Visual Analogue Scale (VAS) of pain and satisfaction. Reoperations were considered surgical failures for purposes of survival analysis.. Results: Mean preoperative anterior and lateral center-edge angles were 35º and 29º, respectively. Mean preoperative alfa angle was 52º. Crossover sign was found in 82% of cases. mHHS changed from 51.06 (SD 4.81) preoperatively to 84.97 (SD 12.79) postoperatively. Preoperative WOMAC was 29.18 (SD 8) and postoperative, 13.10 (SD 11). Postoperative VAS was 7.5 and 2.27 for satisfaction and pain, respectively. When comparing patients with Tönnis 0 to those with Tönnis 1, the former showed better results regarding postoperative mHHS (89.9s vs 77.85, p=0.03), pain VAS (1.5 vs 6.3, p=0.03) and satisfaction VAS (8.2 vs 6.3, p=0.01). Postoperative WOMAC was slightly better for Tönnis 0 patients (8.31 vs 19.3, p=0.05). No differences were found in preoperative WOMAC and mHHS. Three of 44 patients required a second surgical procedure and were considered failures. Survival was 100% at 24 months and 76% at 40 months (95%CI: 35%-98%). Conclusion: Arthroscopic acetabuloplasty without labral detachment achieved good clinical outcomes in all the evaluated scores. Slight degenerative changes on radiographs correlated with poorer clinical outcomes, exhibiting better results in patients without osteoarthritis.
Clinical results in reconstruction of medial patellofemoral ligament
Authors: Irigoitia Nicolas Alejandro , Catan Agustín Felipe , Arroquy Damián , Guiñazu Jorge , Vilaseca Tomas , Nazur Gabriel , Bisso Martín Carboni 
Published: January 2017

Background: The reconstruction of the medial patellofemoral ligament (MPFL) is the most suitable treatment for the patellar instability at the present in patients with two or more episodes of dislocation or only one with condral lesion. This is because it is the principal medial stabilizer of the patella. This process could be supplemented with an osseous correction as tibial tuberosity transference. Objectives: assess the clinical results of the reconstruction of the MPLF in patients with patellar instability. Study Design: Case series, level of evidence IV. Methods: We enroll all patients with this procedure between form April 2011 to February 2015, the sample has 27 reconstruction in 25 patients, who has two or more episodes of patellar dislocation. The graft used was gracilis tendon, set with suture anchor, and tibial tuberosity transfer in 9 patients who need an osseous procedure. Results: The average Kujala score was 90,1 points ( 64-100). Was necessary tibial tuberosity transference in one third of se sample. And in those patients there no difference compared with the isolated reconstruction.There was no episode of patellar dislocation or a second surgical time in the sample. Conclusion: The reconstruction of MPLF show excellent clinical outcomes in a short and medium terms , with 0% of dislocation and no second surgical time, in this kind of patients.
Single-Stage Reconstruction of Both Cruciate Ligaments
Authors: Andreoli Mauro , Zicaro Juan Pablo , Yacuzzi Carlos , Costa-Paz Matias 
Published: January 2017

Objectives: Isolated Anterior Cruciate Ligament (ACL) and Posterior Cruciate Ligament (PCL), or central pivot lesions are rare. These are frequently associated with collateral ligaments injuries. The purpose of this retrospective study was to evaluate clinical and functional outcomes of 4 patients with acute ACL and PCL injury who underwent a simultaneous single-stage arthroscopic reconstruction. Methods: The inclusion criteria were patients with isolated ACL and PCL injuries, with a minimum follow-up of 2 years. We evaluated the type of graft used, the surgical technique and postoperative complications. The scales used for clinical evaluation were the Knee Society Score (KSS), IKDC, Lysholm and Tegner. Knee stability was assessed using the KT-1000 arthrometer. Results: Three men and one woman, with an average age of 48 years (45 to 56 years) were evaluated. Three presented a sport injury and one a car accident. Mean follow-up was 8 years. In all patients allograft was used for ligament reconstruction. Average postoperative results were: KSS 74-82, Lysholm 76, IKDC 63 and Tegner 6. KT-1000 arthrometer showed an average difference of 4mm compared to the contralateral knee. One patient underwent reintervention due to meniscal injury. Conclusion: ACL and PCL simultaneous single-stage reconstruction is a really demanding surgery. We achieved good results using allograft for both ligaments reconstruction. No clinical or functional postoperative complications were recorded.
ACL Revision
Authors: Costa-Paz Matias , Dubois Julieta Puig , Zicaro Juan Pablo , Rasumoff Alejandro , Yacuzzi Carlos 
Published: January 2017

Objectives: The purpose of this study was to evaluate a series of patients one year after an ACL revision with clinical evaluation and MRI, to consider their condition before returning to sports activities. Methods: A descriptive, prospective and longitudinal study was performed. A series of patients who underwent an ACL revision between March 2014 and March 2015 were evaluated after one year post surgery. They were evaluated using the Lysholm score, IKDC, Tegner, artrometry and MRI (3.0 t). A signal pattern and osteointegration was determined in the MRI. Graft signal intensity of the ACL graft using the signal/noise quotient value (SNQ) was also determined to evaluate the ligamentatization process state. Results: A total of 18 male patients were evaluated with a mean age of 31 years old.Average scores were: Lysholm 88 points, IKDC 80 points, Pre-surgical Tegner 9 points and postoperative 4 points. Artrhometry (KT1000) at 20 newtons showed a side to side difference of less than 3 mm in 88%. Only 44% of patients returned to their previous sport activity one year after revision.The MRI showed a heterogeneous signal in neoligaments in 34% of patients. SNQ showed graft integration in only 28%. Synovial fluid was found in bone-graft interphase in 44% of tunnels, inferring partial osteointegration. The heterogeneous signal was present in 50% of patients who did not return to the previous sport level activity. (Fisher statistics: p = 0.043) There were no meaningful differences in patients with auto or allografts. Conclusion: Although the clinical evaluation was satisfactory, only 44% of patients returned to the previous level of sport activity one year after the ACL surgery. The ligamentatization process was found in 28% of knees evaluated with MRI one year later. Partial osteointegration is inferred in 44%. Results showed a meaningful relation between the signal of neoligaments in the MRI and the return to sport activity in said series of patients. MRI is a useful tool to consider the return to sports one year after the ACL revision.
Anti-CD20-interleukin-21 fusokine targets malignant B cells via direct apoptosis and NK-cell–dependent cytotoxicity
Authors: Bhatt Shruti , Parvin Salma , Zhang Yu , Cho Hyun-Mi , Kunkalla Kranthi , Vega Francisco , Timmerman John M. , Shin Seung-Uon , Rosenblatt Joseph D. , Lossos Izidore S. 
Published: January 2017

Key Points
Delivering IL-21 to tumor B cells by fusion with anti-CD20 antibody (αCD20-IL-21 fusokine) is a potent antilymphoma therapeutic strategy. αCD20-IL-21 fusokine demonstrated superior antilymphoma activity compared with its individual components.
Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia
Authors: Tripura Rupam , Peto Thomas J. , Veugen Christianne C. , Nguon Chea , Davoeung Chan , James Nicola , Dhorda Mehul , Maude Richard J. , Duanguppama Jureeporn , Patumrat Krittaya , Imwong Mallika , von Seidlein Lorenz , Grobusch Martin P. , White Nicholas J. , Dondorp Arjen M. 
Published: January 2017

Abstract
Background
Cambodia has seen a marked reduction in the incidence of Plasmodium falciparum over the past decade without a corresponding decline in Plasmodium vivax incidence. It is unknown to what extent local transmission is sustained by a chain of clinical and sub-clinical infections or by continued re-introduction via migration. Using an ultrasensitive molecular technique, 20 villages in western Cambodia were surveyed to detect the low season prevalence of P. falciparum and P. vivax and local treatment records were reviewed.

Methods
During March to May 2015 cross-sectional surveys were conducted in 20 villages in Battambang, western Cambodia. Demographic and epidemiological data and venous blood samples were collected from 50 randomly selected adult volunteers in each village. Blood was tested for Plasmodium infections by rapid diagnostic test (RDT), microscopy and high volume (0.5 ml packed red blood cell) quantitative polymerase chain reaction (uPCR). Positive samples were analysed by nested PCR to determine the Plasmodium species. Malaria case records were collected from the Provincial Health Department and village malaria workers to determine incidence and migration status.

Results
Among the 1000 participants, 91 (9.1%) were positive for any Plasmodium infection by uPCR, seven (0.7%) by microscopy, and two (0.2%) by RDT. uPCR P. vivax prevalence was 6.6%, P. falciparum 0.7%, and undetermined Plasmodium species 1.8%. Being male (adjusted OR 2.0; 95% CI 1.2-3.4); being a young adult <30 years (aOR 2.1; 95% CI 1.3–3.4); recent forest travel (aOR 2.8; 95% CI 1.6–4.8); and, a history of malaria (aOR 5.2; 95% CI 2.5–10.7) were independent risk factors for parasitaemia. Of the clinical malaria cases diagnosed by village malaria workers, 43.9% (297/634) and 38.4% (201/523) were among migrants in 2013 and in 2014, respectively. Plasmodium vivax prevalence determined by uPCR significantly correlated with vivax malaria incidences in both 2014 and 2015 (p = 0.001 and 0.002, respectively), whereas no relationship was observed in falciparum malaria (p = 0.36 and p = 0.59, respectively).

Discussion
There was heterogeneity in the malaria parasite reservoir between villages, and Plasmodium prevalence correlated with subsequent malaria incidence. The association was attributable chiefly to P. vivax infections, which were nine-fold more prevalent than P. falciparum infections. In the absence of a radical cure with 8-aminoquinolines, P. vivax transmission will continue even as P. falciparum prevalence declines. Migration was associated with over a third of incident cases of clinical malaria.
Trial registration clinicaltrials.gov (NCT01872702). Registered 4 June 2013
Common coupled fixed point results for operators without mixed monotone type properties and application to nonlinear integral equations
Authors: Machrafi Nabil 
Published: January 2017

AbstractWe establish some new common coupled fixed point theorems for a pair of operators not assumed to satisfy mixed monotone type properties in the ordered Banach space setting. For that purpose, the notions of weakly inflationary and weakly deflationary operators are introduced in the two-dimensional setting, and existence and uniqueness common coupled fixed point theorems for such operators are established under certain condensing and contractive conditions involving the two-dimensional setting. As an application, we study the existence and uniqueness of nonnegative solutions for nonlinear integral equations.
Epigenetics of oropharyngeal squamous cell carcinoma: Opportunities for novel chemotherapeutic targets
Authors: Lindsay Cameron , Seikaly Hadi , Biron Vincent L. 
Published: January 2017

Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. The role of epigenetics in oropharyngeal squamous cell carcinoma (OPSCC) has recently been recognized, with implications for novel biomarkers, molecular diagnostics and chemotherapeutics. In this review, important epigenetic pathways in human papillomavirus (HPV) positive and negative OPSCC are summarized, as well as the potential clinical utility of this knowledge. This material has never been published and is not currently under evaluation in any other peer-reviewed publication.
Draft genome sequences of eight bacteria isolated from the indoor environment: Staphylococcus capitis strain H36, S. capitis strain H65, S. cohnii strain H62, S. hominis strain H69, Microbacterium sp. strain H83, Mycobacterium iranicum strain H39, Plantibacter sp. strain H53, and Pseudomonas oryzihabitans strain H72
Authors: Lymperopoulou Despoina S. , Coil David A. , Schichnes Denise , Lindow Steven E. , Jospin Guillaume , Eisen Jonathan A. , Adams Rachel I. 
Published: January 2017

AbstractWe report here the draft genome sequences of eight bacterial strains of the genera Staphylococcus, Microbacterium, Mycobacterium, Plantibacter, and Pseudomonas. These isolates were obtained from aerosol sampling of bathrooms of five residences in the San Francisco Bay area. Taxonomic classifications as well as the genome sequence and gene annotation of the isolates are described. As part of the “Built Environment Reference Genome” project, these isolates and associated genome data provide valuable resources for studying the microbiology of the built environment.
Formative pluripotency: the executive phase in a developmental continuum
Authors: Smith Austin 
Published: January 2017

ABSTRACT
The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception of pluripotency as an intrinsically metastable and precarious state. However, in the embryo and in defined culture environments the properties of pluripotent cells change in an orderly sequence. Two phases of pluripotency, called naïve and primed, have previously been described. In this Hypothesis article, a third phase, called formative pluripotency, is proposed to exist as part of a developmental continuum between the naïve and primed phases. The formative phase is hypothesised to be enabling for the execution of pluripotency, entailing remodelling of transcriptional, epigenetic, signalling and metabolic networks to constitute multi-lineage competence and responsiveness to specification cues.
Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology
Authors: Demetriadou Anthi , Morales-Sanfrutos Julia , Nearchou Marianna , Baba Otto , Kyriacou Kyriacos , Tate Edward W. , Drousiotou Anthi , Petrou Petros P. 
Published: January 2017

ABSTRACT
Starch binding domain-containing protein 1 (Stbd1) is a carbohydrate-binding protein that has been proposed to be a selective autophagy receptor for glycogen. Here, we show that mouse Stbd1 is a transmembrane endoplasmic reticulum (ER)-resident protein with the capacity to induce the formation of organized ER structures in HeLa cells. In addition to bulk ER, Stbd1 was found to localize to mitochondria-associated membranes (MAMs), which represent regions of close apposition between the ER and mitochondria. We demonstrate that N-myristoylation and binding of Stbd1 to glycogen act as major determinants of its subcellular targeting. Moreover, overexpression of non-myristoylated Stbd1 enhanced the association between ER and mitochondria, and further induced prominent mitochondrial fragmentation and clustering. Conversely, shRNA-mediated Stbd1 silencing resulted in an increase in the spacing between ER and mitochondria, and an altered morphology of the mitochondrial network, suggesting elevated fusion and interconnectivity of mitochondria. Our data unravel the molecular mechanism underlying Stbd1 subcellular targeting, support and expand its proposed function as a selective autophagy receptor for glycogen and uncover a new role for the protein in the physical association between ER and mitochondria.
Multidimensional earthquake frequency distributions consistent with Non-Extensive statistical physics: The interdependence of magnitude, interevent time and interevent distance in North California
Authors: Tzanis A. , Vallianatos F. , Efstathiou A. 
Published: January 2017

It is now accepted that the active tectonic grain comprises a self-organized complex system, therefore its expression (seismicity) should be manifested in the temporal and spatial statistics of energy release rates, and exhibit memory due to long-range interactions in a fractal-like space-time. Such attributes can be properly understood in terms of Non-Extensive Statistical Physics. In addition to energy release rates expressed by the magnitude M, measures of the temporal and spatial interactions are the time (Δt) and hypocentral distance (Δd) between consecutive events. Recent work indicated that if the distributions of M, Δt and Δd are independent so that the joint probability p(M, Δ t, Δd) factorizes as p(M) p( Δt) p( Δd), earthquake frequency is related to M, Δt and Δd by well defined power-laws consistent with NESP. The present work applies these concepts to investigate the self-organization and temporal/spatial dynamics of North Californian seismicity. The results indicate that the statistical behaviour of seismicity in this area is consistent with NESP predictions and has attributes of universality, as its holds for a very broad range of spatial, temporal and magnitude scales. They also indicate that the expression of the regional active tectonic grain comprises a mixture of processes significantly dependent on Δd, which include near (<100km) and far (>400km) field interactions.