bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of immunosuppressant adherence interventions in transplant recipients: Decoding the streetlight effect
Authors: Duncan S. , Annunziato R. A. , Dunphy C. , LaPointe Rudow D. , Shneider B. L. , Shemesh E. 
Published: December 2017

AbstractNon‐adherence to immunosuppressant medications is an important risk factor for graft dysfunction. To evaluate the effectiveness of adherence‐enhancing interventions, we reviewed adherence intervention studies in solid organ transplant recipients (all ages). Using the following databases: PsycINFO, PubMed, Scopus, and ScienceDirect, we identified 41 eligible studies. Only three non‐randomized trials showed a possible positive effect on objective indicators of transplant outcomes (such as rejection, liver enzyme levels, kidney function). None of the 21 RCTs showed an improvement in transplant outcomes. Three studies showed a higher rate of adverse events in the intervention group as compared with controls, although this may be related to ascertainment bias. Improvement in adherence as measured indirectly (eg, with electronic monitoring devices) was not aligned with effects on transplant outcomes. We conclude that adherence interventions, to date, have largely been ineffective in improving transplant outcomes. To improve this track record, intervention efforts may wish to concentrate on non‐adherent patients (rather than use convenience sampling, which excludes many of the patients who need the intervention), use direct measures of adherence to guide the interventions, and employ strategies that are intensive and yet engaging enough to ensure that non‐adherent patients are able to participate.
Consideration of children with intellectual disability as candidates for solid organ transplantation—A practice in evolution
Authors: Wightman Aaron , Diekema Douglas , Goldberg Aviva 
Published: December 2017

AbstractChildren with intellectual disability were historically excluded from consideration as recipients of solid organ transplants. In light of an evolution in provider practices, this commentary will define intellectual disability and review the relevant provider attitudes and guidelines and known outcomes of solid organ transplant in this population.
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation
Authors: Narumoto Soichi , Sakamoto Seisuke , Uchida Hajime , Sasaki Kengo , Shigeta Takanobu , Fukuda Akinari , Nosaka Shunsuke , Irie Rie , Yoshioka Takako , Kasahara Mureo 
Published: December 2017

AbstractNEC is an idiopathic intestinal mucosal injury that may progress to transmural bowel necrosis without mesenteric ischemia. NEC usually affects 7‐ to 10‐day‐old neonates following enteral feeding. A 10‐month‐old girl with no history of laparotomy underwent LDLT for acute liver failure. After starting enteral feeding on postoperative day 5, she developed abdominal distention. Diffuse PVG and PI were detected by radiologic modalities. Exploratory laparotomy revealed patchy necrosis of the intestine without perforation. The microscopic findings of a resected specimen revealed transmural coagulative necrosis with multiple small thromboses compatible with neonatal NEC features, and eosinophil infiltration was also observed. Subsequently, after the resumption of enteral feeding with cow's milk, she developed severe diarrhea, the symptoms of which were eliminated after the administration of cow's milk was stopped. These clinical and pathological findings support the speculation that NEC might have been induced by a CMA. Food allergies, which can be induced by immunosuppressive agents, should be considered as a potential cause of NEC in the setting of pediatric liver transplantation.
Examining the potential for porcine‐derived islet cells to harbour viral pathogens
Authors: Crossan Claire , O'Hara Zoe , Mourad Nizar , Gianello Pierre , Scobie Linda 
Published: December 2017

AbstractWith an onus on safety in the potential use of porcine islet cells as a treatment for diabetes, the use of animals lacking exogenous pathogens is clearly important and multilevel screening strategies have been presented on testing animals and the product. In this study, we wished to investigate whether islet cells indeed harboured the same viral pathogens of concern in the source animal. PMBC and islet cells from both adult and neonatal source animals were directly compared and tested for PCMV, PLHV, PCV2, PPV and HEV using both molecular and serological assays. Adult PBMC were found positive for all viruses with the exception of PCV2 and HEV. Neonatal PBMC were only found positive for PCMV and HEV. All animals were found negative for HEV antibodies. Interestingly, islet cells were negative for all viruses tested regardless of status in the animal‐derived PBMC. Given that other laboratories have demonstrated the lack of virus detection during the culture of islets, this study also demonstrates that the hygiene status of the herd may not reflect the status of the product. This is important for establishing guidelines for any risk evaluation and mitigation process utilised during product manufacture.
Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil
Authors: Di Paola Nicholas , Cunha Marielton dos Passos , Durigon Giuliana Stravinskas , Berezin Eitan Naaman , Durigon Edison , Oliveira Danielle Bruna Leal de , Zanotto Paolo Marinho de Andrade 
Published: December 2017

ABSTRACT
Here, we present the complete genome sequences of two human parainfluenza virus type 3 (HPIV-3) isolates collected from hospitalized infants suffering from acute respiratory disease. These are the first complete genome sequences of HPIV-3 originating from Brazil.
Genome Sequence of Listeria monocytogenes Strain F4244, a 4b Serotype
Authors: Bailey Taylor W. , do Nascimento Naila C. , Bhunia Arun K. 
Published: December 2017

ABSTRACT

Listeria monocytogenes
is an opportunistic invasive foodborne pathogen. Here, we performed whole-genome sequencing of
L. monocytogenes
strain F4244 (serotype 4b) using Illumina sequencing. The sequence showed 94.5% identity with strain F2365, serotype 4b, and 90.6% with EGD-e, serotype 1/2a.
Draft Genome Sequence of Lactobacillus salivarius SGL 03, a Novel Potential Probiotic Strain
Authors: Federici Federica , Manna Laura , Rizzi Eleonora , Galantini Elena , Marini Umberto 
Published: December 2017

ABSTRACT

In this work, we report the draft genome sequence of
Lactobacillus salivarius
SGL 03, a novel potential probiotic strain isolated from healthy infant stools. Antibiotic resistance analysis revealed the presence of a tetracycline resistance gene without elements potentially responsible for interspecific horizontal gene transfer.
Draft Genome Sequence of Pseudomonas fragi Strain DBC, Which Has the Ability To Degrade High-Molecular-Weight Polyaromatic Hydrocarbons
Authors: Singha L. Paikhomba , Kotoky Rhitu , Pandey Piyush 
Published: December 2017

ABSTRACT

Pseudomonas fragi
strain DBC was isolated from crude oil-contaminated soil. The genome of
P. fragi
DBC is comprised of 5,072,304 bp with 54.09% GC content. Genes for degradation of polyaromatic hydrocarbons were found in the genome, in addition to genetic elements for related physiological functions such as chemotaxis, detoxification, and quorum sensing.
Long‐Term Prognostic Implications of Cerebral Microbleeds in Chinese Patients With Ischemic Stroke
Authors: Lau Kui Kai , Wong Yuen Kwun , Teo Kay Cheong , Chang Richard S. K. , Tse Man Yu , Hoi Chu Peng , Chan Chung Yan , Chan Oi Ling , Cheung Ryan Hoi Kit , Wong Edmund Ka Ming , Kwan Joseph Shiu Kwong , Hui Edward S. , Mak Henry Ka Fung 
Published: December 2017

Background
This study was performed to determine the clinical correlates and long‐term prognostic implications of microbleed burden and location in Chinese patients with ischemic stroke.

Methods and Results

We recruited 1003 predominantly Chinese patients with ischemic stroke who received magnetic resonance imaging at the University of Hong Kong. We determined the clinical correlates of microbleeds and the long‐term risks (3126 patient‐years of follow‐up) of recurrent ischemic stroke and intracerebral hemorrhage (
ICH
) by microbleed burden (0 versus 1, 2–4, and ≥5) and location, adjusting for age, sex, and vascular risk factors and stratified by antithrombotic use. Microbleeds were present in 450 of 1003 of the study population (119/450 had ≥5, 187/450 had mixed location). Having ≥5 microbleeds was independently associated with prior antiplatelet and anticoagulant use, whereas microbleeds of mixed location were independently associated with hypertension and prior anticoagulant use (all
P
<0.05). Microbleed burden was associated with an increased risk of
ICH
(microbleed burden versus no microbleeds: 1 microbleed: multivariate hazard ratio: 0.59 [95% confidence interval, 0.07–5.05]; 2–4 microbleeds: multivariate hazard ratio: 2.14 [95% confidence interval, 0.50–9.12]; ≥5 microbleeds: multivariate hazard ratio: 9.51 [95% confidence interval, 3.25–27.81];
P
trend
<0.0001), but the relationship of microbleed burden and risk of recurrent ischemic stroke was not significant (
P
trend
=0.054). Similar findings were noted in the 862 of 1003 patients treated with antiplatelet agents only (
ICH
:
P
trend
<0.0001; ischemic stroke
P
trend
=0.096). Multivariate analysis revealed that, independent of vascular risk factors, antithrombotic use, and other neuroimaging markers of small vessel disease, having ≥5 microbleeds (multivariate hazard ratio: 6.08 [95% confidence interval, 1.11–33.21];
P
=0.037) was identified as an independent predictor of subsequent
ICH
, but neither microbleed burden nor location was predictive of recurrent ischemic stroke risk.

Conclusions

In Chinese patients with ischemic stroke, a high burden of cerebral microbleeds was significantly associated with an increased risk of
ICH
; however, neither microbleed location nor burden was associated with recurrent ischemic stroke risk.
Piper jianfenglingense, a new species of Piperaceae from Hainan Island, China
Authors: HAO CHAO-YUN , QIN XIAO-WEI , TAN LE-HE , HU LI-SONG , WU GANG , LUO SHUI-XING , DENG HAI-YAN , TAN YUN-HONG 
Published: December 2017

Piper jianfenglingense, which was collected in the Jianfengling National Natural Reserve, Hainan Island, China, is described and illustrated herein. Morphologically it is similar to P. mutabile, from which it differs in having sparsely pubescent petioles, vaginate at base only; rachises glabrous; floral bracts adnate to rachis, margin partially hidden; stamens 2, with considerably longer filaments, these caducous when anthers mature; stigmas ovoid, apex acute; berries and seeds ellipsoid. Molecular analyses based on the ITS marker of nuclear ribosomal DNA strongly support P. jianfenglingense as a new species in the genus Piper, most closely related to P. macropodum.
Vitamin B12sources and microbial interaction
Authors: Watanabe Fumio , Bito Tomohiro 
Published: December 2017

Vitamin B12is synthesized only by certain bacteria and archaeon, but not by plants. The synthesized vitamin B12is transferred and accumulates in animal tissues, which can occur in certain plant and mushroom species through microbial interaction. In particular, the meat and milk of herbivorous ruminant animals (e.g. cattle and sheep) are good sources of vitamin B12for humans. Ruminants acquire vitamin B12, which is considered an essential nutrient, through a symbiotic relationship with the bacteria present in their stomachs. In aquatic environments, most phytoplankton acquire vitamin B12through a symbiotic relationship with bacteria, and they become food for larval fish and bivalves. Edible plants and mushrooms rarely contain a considerable amount of vitamin B12, mainly due to concomitant bacteria in soil and/or their aerial surfaces. Thus, humans acquire vitamin B12formed by microbial interaction via mainly ruminants and fish (or shellfish) as food sources. In this review, up-to-date information on vitamin B12sources and bioavailability are also discussed.Impact statementTo prevent vitamin B12(B12) deﬁciency in high-risk populations such as vegetarians and elderly subjects, it is necessary to identify foods that contain high levels of B12. B12is synthesized by only certain bacteria and archaeon, but not by plants or animals. The synthesized B12is transferred and accumulated in animal tissues, even in certain plant tissues via microbial interaction. Meats and milks of herbivorous ruminant animals are good sources of B12for humans. Ruminants acquire the essential B12through a symbiotic relationship with bacteria inside the body. Thus, we also depend on B12-producing bacteria located in ruminant stomachs. While edible plants and mushrooms rarely contain a considerable amount of B12, mainly due to concomitant bacteria in soil and/or their aerial surfaces. In this mini-review, we described up-to-date information on B12sources and bioavailability with reference to the interaction of microbes as B12-producers.
En transit ou à destination? Le Black Bazar des écrivains migrants africains
Authors: Tsimi Eric Essono 
Published: December 2017

Abstract
Black Bazaar is a real-life satire. Its narrator-author was called Fessologue, rendered ‘Buttologist’ in the English translation. He advanced polemical views about the lives of African immigrants in France. In the absence of an all persons fictitious disclaimer, since Fessologue hails like Mabanckou himself from the ‘little Congo’ and that many satirized characters are based on actual contemporary writers, this article analyses the ‘migritude writers’ through Black Bazaar, the identity novel. Drawing on Bhabha’s (2003, 2012), the paper focuses on the potential of African narratives to properly talk of the subaltern history of francophone African writers and the evolution of their identities across the margins of Paris.
Conical square functions for degenerate elliptic operators
Authors: Chen Li , Martell José María , Prisuelos-Arribas Cruz 
Published: December 2017

Abstract
The aim of the present paper is to study the boundedness of different conical square functions that arise naturally from second-order divergence form degenerate elliptic operators. More precisely, let

L
w

=

-

w

-
1

⁢

div

(

w
⁢
A
⁢
∇

)

{L_{w}=-w^{-1}\mathop{\rm div}(wA\nabla)}

, where

w
∈

A
2

{w\in A_{2}}

and A is an

n
×
n

{n\times n}

bounded, complex-valued,
uniformly elliptic matrix. Cruz-Uribe and Rios solved the

L
2

⁢

(
w
)

{L^{2}(w)}

-Kato square root problem obtaining that

L
w

{\sqrt{L_{w}}}

is equivalent to the gradient on

L
2

⁢

(
w
)

{L^{2}(w)}

. The same authors in collaboration with the second named author of this paper studied the

L
p

⁢

(
w
)

{L^{p}(w)}

-boundedness of operators that are naturally associated with

L
w

{L_{w}}

, such as the functional calculus, Riesz transforms, and vertical square functions. The theory developed admitted also weighted estimates (i.e., estimates in

L
p

⁢

(

v

⁢
d
⁢
w

)

{L^{p}(v\,dw)}

for

v
∈

A
∞

⁢

(
w
)

{v\in A_{\infty}(w)}

), and in particular a class of “degeneracy” weights w was found in such a way that the classical

L
2

{L^{2}}

-Kato problem can be solved. In this paper, continuing this line of research, and also that originated in some recent results by the second and third named authors of the current paper, we study the boundedness on

L
p

⁢

(
w
)

{L^{p}(w)}

and on

L
p

⁢

(

v

⁢
d
⁢
w

)

{L^{p}(v\,dw)}

, with

v
∈

A
∞

⁢

(
w
)

{v\in A_{\infty}(w)}

, of the conical square functions that one can construct using the heat or Poisson semigroup associated with

L
w

{L_{w}}

. As a consequence of our methods, we find a class of degeneracy weights w for which

L
2

{L^{2}}

-estimates for these conical square functions hold. This opens the door to the study of weighted and unweighted Hardy spaces and of boundary value problems associated with

L
w

{L_{w}}

.
Person as an inflectional category
Authors: Nichols Johanna 
Published: December 2017

AbstractThe category of person has both inflectional and lexical aspects, and the distinction provides a finely graduated grammatical trait, relatively stable in both families and areas, and revealing for both typology and linguistic geography. Inflectional behavior includes reference to speech-act roles, indexation of arguments, discreteness from other categories such as number or gender, assignment and/or placement in syntax, arrangement in paradigms, and general resemblance to closed-class items. Lexical behavior includes sharing categories and/or forms and/or syntactic behavior with major lexical classes (usually nouns) and generally resembling open-class items. Criteria are given here for typologizing person as more vs. less inflectional, some basic typological correlations are tested, and the worldwide linguistic-geographical distribution is mapped.
Whey utilization in a two-stage fermentation process
Authors: Vidra Aladár , Németh Áron 
Published: December 2017

Abstract Whey is a major by-product of the cheese and dairy industry and has valuable nutritional constituents, however poses a major environmental risk if disposed of without prior treatment. The main components of whey except of water are lactose, lactic acid, soluble proteins, lipids, vitamins and mineral salts which give a very high biochemical oxygen demand (BOD) and chemical oxygen demand (COD) load (30,000 - 50,000 ppm and 60.000 - 80,000 ppm, respectively) to the whey. This composition provides adequate nitrogen and carbon source to be utilized by microorganisms. The aim of this study was to examine the whey utilization in a two-stage fermentation process using Lactobacillus species and Propionibacterium acidipropionici. In the first stage Lactobacillus species utilise the main part of the nitrogen source while covert lactose content to lactic acid. In the second stage Propionibacterium acidipropionici utilize lactic acid and produce propionic acid. This two-stage fermentation process can be a feasible option, both for bioremediation of whey and production of propionic acid from waste sources. High lactose conversion (>90%) to lactic acid was achieved at the first stage, but its conversion to propionic acid during the second stage was insufficient (~30%). The COD was successfully decreased during the fermentations.
A population-based study of the effectiveness of stereotactic ablative radiotherapy versus conventional fractionated radiotherapy for clinical stage I non-small cell lung cancer patients
Authors: Tu Chih-Yen , Hsia Te-Chun , Fang Hsin-Yuan , Liang Ji-An , Yang Su-Tso , Li Chia-Chin , Chien Chun-Ru 
Published: December 2017

Abstract

Background
Stereotactic ablative radiotherapy (SABR) is a promising option for non-operated early-stage non-small cell lung cancer (NSCLC) compared to conventional fractionated radiotherapy (CFRT). However, results from conclusive randomized controlled trials are not yet available. The aim of our study was to explore the effectiveness of SABR vs. CFRT for non-operated early-stage NSCLC.

Patients and methods
We used a comprehensive population-based database to identify clinical stage I non-operated NSCLC patients in Taiwan diagnosed from 2007 to 2013 who were treated with either SABR or CFRT. We used inverse probability weighting and the propensity score as the primary form of analysis to address the nonrandomization of treatment. In the supplementary analyses, we constructed subgroups based on propensity score matching to compare survival between patients treated with SABR vs. CFRT.

Results
We identified 238 patients in our primary analysis. A good balance of covariates was achieved using the propensity score weighting. Overall survival (OS) was not significantly different between those treated with SABR vs. CFRT (SABR vs. CFRT: probability weighting adjusted hazard ratio [HR] 0.586, 95% confidence interval 0.264–1.101, p = 0.102). However, SABR was significantly favored in supplementary analyses.

Conclusions
In this population-based propensity-score adjusted analysis, we found that OS was not significantly different between those treated with SABR vs. CFRT in the primary analysis, although significance was observed in the supplementary analyses. Our results should be interpreted with caution given the database (i.e., nonrandomized) approach used in our study. Overall, further studies are required to explore these issues.
Wenn Roboter „mitreden“...
Authors: Antos Gerd 
Published: December 2017

Abstract
Will social bots change our current understanding of linguistic communication? Will synthetic speech still be distinguishable from human expressions? Are neural algorithms superseding conventional arguments in their communicative impact? Further: Isn't it already the case that software functionally outmatches language(s)?
Outlined in 12 theses, this essay argues for the need to research “disruption” in the setting of the flourishing subject of media linguistics: In how far is our culturally-shaped language being “disrupted”, i. e. “destructed with creative potential”, through digitalisation? What forms of human-machine co-evolutions will be established instead? Moreover: Will language still be the foundation and engine for our cultural evolution? Or will communication change from being “human-centric” to becoming “data-centric”?
Werden mit uns interagierende Roboter unser bisheriges Verständnis von sprachbasierter Verständigung verändern? Werden synthetisierte Sprach-Imitate von menschlichen Äußerungen kaum mehr zu unterscheiden sein? Sind netzbasierte Algorithmen kommunikativ wirkungsvoller als Argumente? Und: Ist Software nicht längst Sprache(n) funktional überlegen?
Vor dem Hintergrund einer aufblühenden Medienlinguistik plädiert der Essay in 12 Thesen für eine linguistische Disruptions-Forschung: Inwieweit wird unsere tradierte Sprachkultur von der Digitalisierung „disruptiv“, d. h. „kreativ zerstört“? Welche Formen der Ko-evolution zwischen Mensch und Maschine etablieren sich stattdessen? Und: Bleibt Sprache Basis und Motor unserer kulturellen Evolution? Oder tritt an Stelle einer „homozentrischen“ eine „datazentrische“ Kommunikation?
Evaluating the Mesostructural Changes of Laboratory Created Soil-Rock Mixtures Using a Seepage Test Based on NMR Technology
Authors: Feng Shangxin , Chai Junrui , Xu Zengguang , Qin Yuan 
Published: December 2017

Abstract
Soil-rock mixtures (S-RMs) have great potential as a material for use in hydropower engineering. However, seepage can change the porosity and structure of such mixtures, which can in turn threaten hydropower engineering structures. The objective of this study was to understand the mesostructural changes in S-RMs when S-RMs undergo seepage failure. Laboratory seepage tests were performed using a custom-made seepage instrument under different hydraulic gradients, i.e., 0, 20, 24, 27, and 30, and under a constant critical hydraulic gradient (30) for different lengths of time, i.e., 15 min, 30 min, 60 min, 120 min, and 180 min. Nuclear magnetic resonance (NMR) can directly determine the physical properties of S-RMs, such as the pore distribution, porosity, and permeability. The results of the NMR tests reveal that the pores in the S-RMs are well developed. As the hydraulic gradient and time increase, the pores are expanded by the hydraulic pressure, and the connectivity of the pores increases. The structure and cohesion of the S-RM can be damaged by hydraulic pressure. When the hydraulic gradient is equal to the critical hydraulic gradient, the S-RM experiences erosion or seepage failure, and these phenomena become increasingly obvious with time. A relatively strong correlation exists between porosity and permeability. Movable fluid porosity contributes considerably more to permeability than does irreducible porosity.