bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of cough headache with transient elevation of intracranial pressure and bilateral internal jugular vein valve incompetence: A primary or secondary headache?
Authors: Liu Huanxian , Cao Xiangyu , Zhang Meichen , He Mianwang , Li Min , Song Yangguang , Dong Zhao , Yu Shengyuan 
Published: April 2017

Background Primary cough headache (PCH) is precipitated by coughing or the Valsalva manoeuver (VM), and its underlying pathophysiology remains unclear. Case report We report a case of recurrent cough headaches precipitated by VM with transient increase of intracranial pressure (ICP) diagnosed by measuring left sigmoid sinus pressure. Bilateral internal jugular vein valve incompetence (IJVVI) was also diagnosed by Doppler ultrasonography during a VM. Indomethacin was administered for over four months, and the headache had completely disappeared at the four-month follow-up. Conclusions Cough headache might be associated with a transient increase of ICP induced by IJVVI, which might partially explain the pathophysiology of VM-induced headache. Detecting the internal jugular vein during a VM might be used as diagnostic procedure for patients who have PCH during resting and VM. If it is necessary, monitoring the ICP could be considered.
Imagining the Balkans as a Space of Revolution: The Federalist Vision of Serbian Socialism, 1870–1914
Authors: Robertson James 
Published: April 2017

Between the years 1870 and 1914, leftist intellectuals in the Kingdom of Serbia theorized and promoted a project of Balkan Federation as a strategic priority in the social, economic, and political transformation of the region. This article offers a genealogy of these federalist ideas and places them in dialogue with rival projects of regional unification in the Balkans and Eastern Europe during the long nineteenth century. It begins by developing a typology of federalist projects in Europe, categorizing these according to the underlying models of sovereignty upon which they were founded. I identify four categories: revolutionary-republican, imperial-reformist, imperial-irredentist, and revolutionary-social. Instead of organizing these federalisms according to their authors’ ideological commitments (socialist, nationalist, pan-Slavic) or their geographic scope (Balkan, Danubian), the article argues that examining their respective models of sovereignty offers intellectual historians a more productive approach to identify the unexpected convergences and divergences of federalist projects during this period. The article then moves into a discussion of the development of Serbian socialist ideas of Balkan Federation, beginning first with the work of Svetozar Marković (1846–1875) and then turning to the writings of the fin de siècle Social Democratic Party in the decade before World War I. Situating this genealogy of socialist Balkan federalism in its broader European intellectual milieu, I use the above typology to identify the ways in which Serbian socialists converged and diverged from contemporary federalist projects, including the reformist ideas of the Austro-Marxists, the irredentist strategy of the Serbian Progressive Party, and the republican ideas of Karel Kautsky.
Patient safety in nursing homes in Sweden: nurses’ views on safety and their role
Authors: Andersson Frieda , Hjelm Katarina 
Published: April 2017

Objective Knowledge about patient safety in nursing homes is limited. The aim of this study was to describe what patient safety means to nurses working in nursing homes for the elderly and how these nurses address patient safety. Method Qualitative study of semi-structured interviews with 15 nurses aged 27–62 years. Qualitative content analysis was applied. Results Nurses describe the meaning of patient safety in terms of proper care and treatment, and a sense of security. Based on nurses’ description of patient safety, several factors were identified as prerequisites to achieve safe health care: competence; clear information transfer between health care organizations; continuity of care and appropriate environment. Barriers to patient safety were described as lack of sufficient resources; lack of communication and negative attitudes to incident reporting. To a great extent, nurses’ work for patient safety consists of efforts to compensate for defects and ensure good health care in their daily work, since work with patient safety is not a management priority. Conclusion Patient safety needs to be clarified and prioritized in nursing homes, and there is a need to understand nurses’ role among other care givers and the need for shared routines among care givers.
Analyzing the Effects of Psychotherapy on Weight Loss after Laparoscopic Gastric Bypass or Laparoscopic Adjustable Gastric Banding in Patients with Borderline Personality Disorder: A Prospective Study
Authors: Gallé F. , Cirella A. , Salzano A. M. , Onofrio V. Di , Belfiore P. , Liguori G. 
Published: April 2017

Background and Aims: Personality disorders are frequently associated with eating disorders in obese patients and may negatively affect weight loss and maintenance after bariatric surgery. This non-randomized study aimed to assess the effects of different psychotherapeutic interventions on weight loss in a sample of patients with borderline personality disorder who underwent laparoscopic gastric bypass or laparoscopic adjustable gastric banding. Materials and Methods: A total of 153 bariatric patients meeting borderline personality disorder criteria were chosen voluntarily and consecutively to undergo an interpersonal individual treatment (n = 50), a dialectical behavioral group treatment (n = 50), or treatment as usual (n = 53) for a year after surgery. Their body mass index was measured before and at the end of each treatment. Results and Conclusion: A total of 12 patients (7.8%) dropped out of the study. Significantly higher body mass index reductions were registered in both experimental groups (−14.2 and −9.4 kg/m2, respectively) compared with the treatment as usual group (−2.1 kg/m2; p < 0.01). Treated patients who underwent laparoscopic gastric bypass (total n = 94) showed better outcomes than those who underwent laparoscopic adjustable gastric banding (total n = 45), while no differences were observed in untreated patients. This study demonstrates the role of pre-operative psychological assessment and post-operative psychotherapeutic support in improving weight loss among bariatric patients with borderline personality disorder. A randomized controlled trial is needed to confirm these preliminary findings.
Performance of apparent diffusion coefficient of medial and lateral rectus muscles in Graves' orbitopathy
Authors: Abdel Razek Ahmed AK , El-Hadidy Mohamed , Moawad Mohamed E , El-Metwaly Nader , El-Said Amr A 
Published: April 2017

Objective The purpose of this study was to determine the performance of the apparent diffusion coefficient in the detection of involvement of the medial and lateral rectus muscles in patients with Graves' orbitopathy. Methods and materials This prospective study was conducted on 33 consecutive patients (16 males, 17 females with a mean age of 36 years) with Graves' orbitopathy and 18 age- and sex-matched volunteers. The patients and volunteers underwent diffusion-weighted magnetic resonance imaging of the orbit in the axial plane using echo-planar imaging. The apparent diffusion coefficient of the medial and lateral rectus muscles was calculated. Results The medial rectus muscle was more affected than the lateral rectus muscle. The mean apparent diffusion coefficient value of the medial and lateral rectus muscles was 1.81 ± 0.19 and 1.72 ± 0.07 × 10−3 mm2/s in patients with Graves' orbitopathy and 1.59 ± 0.06 and 1.51 ± 0.06 × 10−3 mm2/s in volunteers, respectively. There was a significant difference in apparent diffusion coefficient values of the medial and lateral rectus muscles between patients with Graves' orbitopathy and volunteers ( p = 0.001). The classification performance as measured with area under the receiver operator characteristic curve was 0.89 (95% confidence interval: 0.732–0.904). The best performing threshold of the apparent diffusion coefficient value of the medial rectus muscle was 1.69 × 10−3 mm2/s and associated efficiency was 86%, sensitivity was 97%, and specificity was 97%. Conclusion We concluded that the apparent diffusion coefficient of the medial rectus muscle can be used for diagnosis of Graves' orbitopathy.
Increasing physical activity in older adults using STARFISH, an interactive smartphone application (app); a pilot study
Authors: Paul Lorna , Brewster Stephen , Wyke Sally , McFadyen Angus K , Sattar Naveed , Gill Jason MR , Dybus Aleksandra , Gray Cindy M 
Published: April 2017

Background Increasing physical activity in older adults has preventative and therapeutic health benefits. We have developed STARFISH, a smartphone application, to increase physical activity. This paper describes the features of STARFISH, presents the views of older users on the acceptability and usability of the app and reports the results of a six week pilot study of the STARFISH app in older adults. Methods The operationalisation of the behaviour change techniques (BCTs) within the STARFISH app was mapped against the BCT Taxonomy of Michie et al. Sixteen healthy older adults (eight women and eight men; age 71.1 ± 5.2 years) used the app, in groups of four, for six weeks. Focus groups explored the user experience and objective measure of steps per day recorded. Results Participants were very positive about using the STARFISH app, in particular the embedded BCTs of self-monitoring, feedback and social support (in the form of group rewards). Objective step data, available for eight participants, showed that step counts increased by an average of 14% ( p = 0.077, d = 0.56). Conclusion The STARFISH app was acceptable and straightforward to use for older adults. STARFISH has potential to increase physical activity in older adults; however, a fully powered randomised controlled trial is required.
Association of circulating transcriptomic profiles with mortality in sickle cell disease
Authors: Desai Ankit A. , Lei Zhengdeng , Bahroos Neil , Maienschein-Cline Mark , Saraf Santosh L. , Zhang Xu , Shah Binal N. , Nouraie Seyed M. , Abbasi Taimur , Patel Amit R. , Lang Roberto M. , Lussier Yves , Garcia Joe G. N. , Gordeuk Victor R. , Machado Roberto F. 
Published: April 2017

Key Points
We validated the association of a circulating genome-wide gene expression profile with poor outcomes in 3 cohorts of SCD. A composite risk score using this genomic biomarker with clinical risk factors exhibited improved prediction than clinical factors alone.
Molecular convergence in ex vivo models of Diamond-Blackfan anemia
Authors: O'Brien Kelly A. , Farrar Jason E. , Vlachos Adrianna , Anderson Stacie M. , Tsujiura Crystiana A. , Lichtenberg Jens , Blanc Lionel , Atsidaftos Eva , Elkahloun Abdel , An Xiuli , Ellis Steven R. , Lipton Jeffrey M. , Bodine David M. 
Published: April 2017

Key Points
Cultured erythroid cells from DBA patients show impaired growth kinetics and altered transcriptional profiles. Our data predict a link between GATA1 and RP mutations in the regulation of translation in erythroid differentiation.
Pregnancy-associated plasma protein-A is a stronger predictor for adverse cardiovascular outcomes after acute coronary syndrome in type-2 diabetes mellitus
Authors: Li Wei-Ping , Neradilek Moni B. , Gu Fu-Sheng , Isquith Daniel A. , Sun Zhi-Jun , Wu Xing , Li Hong-Wei , Zhao Xue-Qiao 
Published: April 2017

AbstractBackgroundThe risk prediction of pregnancy-associated plasma protein-A (PAPP-A) for future cardiovascular (CV) events post acute coronary syndrome (ACS) in patients with type-2 diabetes mellitus (T2DM) was investigated in comparison to other risk factors.MethodsPAPP-A was measured at hospital admission in 320 consecutive ACS patients (136 with T2DM and 184 without). All patients were followed for 2 years for occurrence of CV death, non-fatal MI or stroke. Effect of PAPP-A on the CV event risk was estimated using Cox regression models. Receiver operating characteristics (ROC) curves were generated to demonstrate the sensitivity and specificity of PAPP-A in predicting CV events.ResultsACS patients with T2DM had higher PAPP-A (19.29 ± 16.36 vs. 13.29 ± 13.90 ng/ml, p < 0.001) and higher rate of CV events 2 years post ACS (27.2 vs. 13.6%, p = 0.002) than those without. Higher levels of PAPP-A were significantly associated with increased risk of CV events during 2-year follow-up [HR = 2.97 for 1 SD increase in log10(PAPP-A), 95% CI 2.11–4.18, p < 0.001] in T2DM and (HR = 3.16, 95% CI 2.27–4.39, p < 0.001) in non-T2DM. Among patients with T2DM, PAPP-A showed a larger area under the curve (AUC 0.79) that was significantly more predictive than hsCRP (AUC 0.64), eGFR (AUC 0.66) and LVEF < 50% (AUC 0.52); predictive ability did not improve significantly by including those factors into the model.ConclusionsPatients with T2DM had higher levels of PAPP-A and increased risk of CV events. Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with T2DM.Trial registrationISRCTN10805074. Registered on 20 January 2017, retrospectively registered.
Selecting image pairs for SfM by introducing Jaccard Similarity
Authors: Kato Takaharu , Shimizu Ikuko , Pajdla Tomas 
Published: April 2017

Abstract
We present a new approach for selecting image pairs that are more likely to match in Structure from Motion (SfM). We propose to use Jaccard Similarity (JacS) which shows how many different visual words is shared by an image pair. In our method, the similarity between images is evaluated using JacS of bag-of-visual-words in addition to tf-idf (term frequency-inverse document frequency), which is popular for this purpose. To evaluate the efficiency of our method, we carry out experiments on our original datasets as well as on “Pantheon” dataset, which is derived from Flickr. The result of our method using both JacS and tf-idf is better than the results of a standard method using tf-idf only.
IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages
Authors: Petes Carlene , Wynick Christopher , Guzzo Christina , Mehta Divya , Logan Sarah , Banfield Bruce W , Basta Sameh , Cooper Andrea , Gee Katrina 
Published: April 2017

Abstract
IL-27 bridges innate and adaptive immunity by modulating cytokine production from myeloid cells and regulating Th cell differentiation. During bacterial infection, TLR4 triggering by LPS induces IL-27 production by monocytes and macrophages. We have previously shown that IL-27 can prime monocytes for LPS responsiveness by enhancing TLR4 expression and intracellular signaling. If unregulated, this could result in damaging inflammation, whereas on the other hand, this may also provide greater responses by inflammatory processes induced in response to bacterial pathogens. A key process in fine-tuning inflammatory responses is activation of the inflammasome, which ultimately results in IL-1β production. Herein, we investigated the molecular mechanisms by which IL-27 modulates LPS-induced IL-1β secretion in monocytes and macrophages. We found that when delivered simultaneously with LPS, IL-27 augments activation of caspase-1 and subsequent release of IL-1β. Furthermore, we determined that IL-27 primes cells for enhanced IL-1β production by up-regulating surface expression of TLR4 and P2X purinoceptor 7 (P2X7) for enhanced LPS and ATP signaling, respectively. These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1β secretion levels triggered by dual LPS–ATP stimulation.
Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial
Authors: Mason Malcolm D. , Clarke Noel W. , James Nicholas D. , Dearnaley David P. , Spears Melissa R. , Ritchie Alastair W.S. , Attard Gerhardt , Cross William , Jones Rob J. , Parker Christopher C. , Russell J. Martin , Thalmann George N. , Schiavone Francesca , Cassoly Estelle , Matheson David , Millman Robin , Rentsch Cyrill A. , Barber Jim , Gilson Clare , Ibrahim Azman , Logue John , Lydon Anna , Nikapota Ashok D. , O’Sullivan Joe M. , Porfiri Emilio , Protheroe Andrew , Srihari Narayanan Nair , Tsang David , Wagstaff John , Wallace Jan , Walmsley Catherine , Parmar Mahesh K.B. , Sydes Matthew R. ,   for the STAMPEDE Investigators
Published: April 2017

Purpose Systemic Therapy for Advanced or Metastatic Prostate Cancer: Evaluation of Drug Efficacy is a randomized controlled trial using a multiarm, multistage, platform design. It recruits men with high-risk, locally advanced or metastatic prostate cancer who were initiating long-term hormone therapy. We report survival data for two celecoxib (Cel)-containing comparisons, which stopped accrual early at interim analysis on the basis of failure-free survival. Patients and Methods Standard of care (SOC) was hormone therapy continuously (metastatic) or for ≥ 2 years (nonmetastatic); prostate (± pelvic node) radiotherapy was encouraged for men without metastases. Cel 400 mg was administered twice a day for 1 year. Zoledronic acid (ZA) 4 mg was administered for six 3-weekly cycles, then 4-weekly for 2 years. Stratified random assignment allocated patients 2:1:1 to SOC (control), SOC + Cel, or SOC + ZA + Cel. The primary outcome measure was all-cause mortality. Results were analyzed with Cox proportional hazards and flexible parametric models adjusted for stratification factors. Results A total of 1,245 men were randomly assigned (Oct 2005 to April 2011). Groups were balanced: median age, 65 years; 61% metastatic, 14% N+/X M0, 25% N0M0; 94% newly diagnosed; median prostate-specific antigen, 66 ng/mL. Median follow-up was 69 months. Grade 3 to 5 adverse events were seen in 36% SOC-only, 33% SOC + Cel, and 32% SOC + ZA + Cel patients. There were 303 control arm deaths (83% prostate cancer), and median survival was 66 months. Compared with SOC, the adjusted hazard ratio was 0.98 (95% CI, 0.80 to 1.20; P = .847; median survival, 70 months) for SOC + Cel and 0.86 (95% CI, 0.70 to 1.05; P =.130; median survival, 76 months) for SOC + ZA + Cel. Preplanned subgroup analyses in men with metastatic disease showed a hazard ratio of 0.78 (95% CI, 0.62 to 0.98; P = .033) for SOC + ZA + Cel. Conclusion These data show no overall evidence of improved survival with Cel. Preplanned subgroup analyses provide hypotheses for future studies.
Clinical Prediction Model and Tool for Assessing Risk of Persistent Pain After Breast Cancer Surgery
Authors: Meretoja Tuomo J. , Andersen Kenneth Geving , Bruce Julie , Haasio Lassi , Sipilä Reetta , Scott Neil W. , Ripatti Samuli , Kehlet Henrik , Kalso Eija 
Published: April 2017

Purpose Persistent pain after breast cancer surgery is a well-recognized problem, with moderate to severe pain affecting 15% to 20% of women at 1 year from surgery. Several risk factors for persistent pain have been recognized, but tools to identify high-risk patients and preventive interventions are missing. The aim was to develop a clinically applicable risk prediction tool. Methods The prediction models were developed and tested using three prospective data sets from Finland (n = 860), Denmark (n = 453), and Scotland (n = 231). Prediction models for persistent pain of moderate to severe intensity at 1 year postoperatively were developed by logistic regression analyses in the Finnish patient cohort. The models were tested in two independent cohorts from Denmark and Scotland by assessing the areas under the receiver operating characteristics curves (ROC-AUCs). The outcome variable was moderate to severe persistent pain at 1 year from surgery in the Finnish and Danish cohorts and at 9 months in the Scottish cohort. Results Moderate to severe persistent pain occurred in 13.5%, 13.9%, and 20.3% of the patients in the three studies, respectively. Preoperative pain in the operative area ( P < .001), high body mass index ( P = .039), axillary lymph node dissection ( P = .008), and more severe acute postoperative pain intensity at the seventh postoperative day ( P = .003) predicted persistent pain in the final prediction model, which performed well in the Danish (ROC-AUC, 0.739) and Scottish (ROC-AUC, 0.740) cohorts. At the 20% risk level, the model had 32.8% and 47.4% sensitivity and 94.4% and 82.4% specificity in the Danish and Scottish cohorts, respectively. Conclusion Our validated prediction models and an online risk calculator provide clinicians and researchers with a simple tool to screen for patients at high risk of developing persistent pain after breast cancer surgery.
Impact of 70-Gene Signature Use on Adjuvant Chemotherapy Decisions in Patients With Estrogen Receptor–Positive Early Breast Cancer: Results of a Prospective Cohort Study
Authors: Kuijer Anne , Straver Marieke , den Dekker Bianca , van Bommel Annelotte C.M. , Elias Sjoerd G. , Smorenburg Carolien H. , Wesseling Jelle , Linn Sabine C. , Rutgers Emiel J.Th. , Siesling Sabine , van Dalen Thijs 
Published: April 2017

Purpose Gene-expression profiles increasingly are used in addition to conventional prognostic factors to guide adjuvant chemotherapy (CT) decisions. The Dutch guideline suggests use of validated gene-expression profiles in patients with estrogen receptor (ER) –positive, early-stage breast cancer without overt lymph node metastases. We aimed to assess the impact of a 70-gene signature (70-GS) test on CT decisions in patients with ER-positive, early-stage breast cancer. Patients and Methods In a prospective, observational, multicenter study in patients younger than 70 years old who had undergone surgery for ER-positive, early-stage breast cancer, physicians were asked whether they intended to administer adjuvant CT before deployment of the 70-GS test and after the test result was available. Results Between October 1, 2013, and December 31, 2015, 660 patients, treated in 33 hospitals, were enrolled. Fifty-one percent of patients had pT1cN0, BRII, HER2-Neu-negative breast cancer. On the basis of conventional clinicopathological characteristics, physicians recommended CT in 270 (41%) of the 660 patients and recommended withholding CT in 107 (16%) of the 660 patients. For the remaining 43% of patients, the physicians were unsure and unable to give advice before 70-GS testing. In patients for whom CT was initially recommended or not recommended, 56% and 59%, respectively, were assigned to a low-risk profile by the 70-GS (κ, 0.02; 95% CI, -0.08 to 0.11). After disclosure of the 70-GS test result, the preliminary advice was changed in 51% of patients who received a recommendation before testing; the definitive CT recommendation of the physician was in line with the 70-GS result in 96% of patients. Conclusion In this prospective, multicenter study in a selection of patients with ER-positive, early-stage breast cancer, 70-GS use changed the physician-intended recommendation to administer CT in half of the patients.