bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of type of underlay film on fermentation profile, nutritional quality and estimated loss of organic matter in the outer layer of whole‐plant maize ensiled in large bunker silos
Authors: Wang K. , Uriarte M. E. , Li S. C. , Rich K. , Banchero C. , Bu D. P. , Wilkinson J. M. , Bolsen K. K. 
Published: February 2017

AbstractLosses of organic matter in the outer layers of bunker silos covered with conventional polyethylene (PE) plastic can be substantial due to oxygen transmission through the plastic top‐covering film during the post‐ensiling storage period. The effect of two silo covering materials, oxygen barrier (OB) film (45 μm thickness) and clear PE film (50 μm thickness), as underlays to a white‐on‐black PE plastic top cover (120 μm thickness), was assessed in the outer layer of whole‐plant maize silage stored in three large bunker silos in the People's Republic of China. Samples of the crop at harvest and of silage from the upper 45 cm layer at 5 months post‐ensiling, prior to removal of silage for feed‐out, were analysed for DM, fermentation profile and chemical composition. Loss of OM was estimated from concentrations of ash in the crop at harvest and in the silage. Differences between underlay films in silage fermentation profile were small. Silage protected with OB underlay film had higher mean concentration of starch (p < .008) and higher mean NDF digestibility (p < .003) than silage under PE underlay film. Concentrations of ash were lower (p < .001) for silage covered with OB film than for PE film in all three trials. Mean estimated losses of OM were 170 g/kg for OB underlay film and 232 g/kg for PE underlay film (p < .001), and whole‐silo estimated net economic benefits to OB underlay film ranged from 0.17 to 0.74 US $ per tonne fresh crop ensiled.
Prognostic significance of CD9 expression differs between tumour cells and stromal immune cells, and depends on the molecular subtype of the invasive breast carcinoma
Authors: Kwon Hee Jung , Choi Jung Eun , Kang Su Hwan , Son Youlim , Bae Young Kyung 
Published: February 2017

AimsCD9, a tetraspanin transmembrane protein, modulates cell motility, migration, and proliferation. The aim of this study was to investigate the prognostic significance of CD9 expression in patients with invasive breast carcinoma (IBC).Methods and resultsCD9 expression was evaluated in tissue microarrays of 1349 IBC samples via immunohistochemistry. CD9 expression in tumour cells (T‐CD9 expression) and CD9 expression in stromal immune cells (S‐CD9 expression) were analysed separately. T‐CD9 expression was observed in 732 (54.3%) cases, and was associated with lymph node metastasis, histological type, lymphovascular invasion, high histological grade, HER2 positivity, a high Ki67 labelling index, and distant metastasis. S‐CD9 expression was observed in 833 (61.7%) cases, and was associated with large tumour size, histological type, high histological grade, negative hormone receptors, HER2 positivity, a high Ki67 labelling index, and tumour‐infiltrating lymphocytes. Patients with T‐CD9 expression had shorter disease‐free survival (DFS) than those without T‐CD9 expression in the univariate and multivariate analyses. However, S‐CD9 expression correlated significantly with a favourable DFS in the univariate and multivariate analyses. In the subgroup analysis, T‐CD9 expression and S‐CD9 expression were independent markers for DFS in luminal A and luminal B (HER2‐negative) subgroups, respectively.ConclusionsT‐CD9 expression could be a biomarker for poor prognosis in luminal A IBC, whereas S‐CD9 expression could be a marker of good prognosis in luminal B (HER2‐negative) IBC. Therefore, tumour compartment‐specific analyses considering molecular subtypes are necessary to study the prognostic significance of CD9 expression in IBC.
Nursing handovers: An integrative review of the different models and processes available
Authors: Bakon Shannon , Wirihana Lisa , Christensen Martin , Craft Judy 
Published: February 2017

AbstractThe aim of this study is to explore the different handover models and processes available and their efficacy in improving handover communication within nursing practice. The handover of information is a key nursing responsibility that ensures patient outcomes through continuity of care. This process is widely recognised as an opening for error that may comprise patient safety. This paper is an integrative literature review that employed an inductive exploratory design. A computerised database search was employed including CINAHL, PubMed and Science Direct and a manual citation search with included papers limited to papers published 2005–2016, in English with full text freely available. This included a systematic search strategy, a critical appraisal of the papers utilising the Critical Appraisal Skills Programme, an inductive data extraction and thematic analysis. Sixteen papers were included in this review. The results detailed that there are various handover models in use, yet there is no evidence that any one model displays superior efficacy. The iSoBAR model and its adaptations remain the only model employed across various specialties. More research is warranted to determine if any handover model displays superior efficacy or transferability.
Development of simulation‐based learning programme for improving adherence to time‐out protocol on high‐risk invasive procedures outside of operating room
Authors: Jeong Eun Ju , Chung Hyun Soo , Choi Jeong Yun , Kim In Sook , Hong Seong Hee , Yoo Kyung Sook , Kim Mi Kyoung , Won Mi Yeol , Eum So Yeon , Cho Young Soon 
Published: February 2017

AbstractThe aim of this study was to develop a simulation‐based time‐out learning programme targeted to nurses participating in high‐risk invasive procedures and to figure out the effects of application of the new programme on acceptance of nurses. This study was performed using a simulation‐based learning predesign and postdesign to figure out the effects of implementation of this programme. It was targeted to 48 registered nurses working in the general ward and the emergency department in a tertiary teaching hospital. Difference between acceptance and performance rates has been figured out by using mean, standard deviation, and Wilcoxon‐signed rank test. The perception survey and score sheet have been validated through content validation index, and the reliability of evaluator has been verified by using intraclass correlation coefficient. Results showed high level of acceptance of high‐risk invasive procedure (P<.01). Further, improvement was consistent regardless of clinical experience, workplace, or experience in simulation‐based learning. The face validity of the programme showed over 4.0 out of 5.0. This simulation‐based learning programme was effective in improving the recognition of time‐out protocol and has given the participants the opportunity to become proactive in cases of high‐risk invasive procedures performed outside of operating room.
Self‐determined motivation and exercise behaviour in COPD patients
Authors: Cho Hui‐Ling , Tung Heng‐Hsin , Lin Ming‐Shian , Hsu Wan‐Chun , Lee Chi‐Pin 
Published: February 2017

AbstractThe purpose of this study was to evaluate the self‐determined motivation predictors of exercise behaviour following pulmonary rehabilitation in COPD recipients. This cross‐sectional study was conducted with 135 COPD patients. A demographic questionnaire, clinical factors, behavioural regulations in exercise questionnaire, and leisure time exercise questionnaire were used to collect data. A logistic regression model was used to identify the predictors associated with demographics and self‐determined motivation types regarding physical activity. Education level, episodes of acute exacerbation within 2 years, and identified regulation were significant predictors of executing physical activities with high metabolic equivalents. The results of this study imply that healthcare providers need to be aware of the importance of exercise motivation among COPD patients.
Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial
Authors: Uysal Neşe , Kutlutürkan Sevinç , Uğur Işıl 
Published: February 2017

AbstractThis randomized controlled clinical study aimed to determine the effect of 2 foot massage methods on symptom control in people with colorectal cancer who received chemoradiotherapy. Data were collected between June 16, 2015, and February 10, 2016, in the Department of Radiation Oncology of an oncology training and research hospital. The sample comprised 60 participants. Data were collected using an introductory information form, common terminology criteria for adverse events and European Organization for Research and Treatment of Cancer Quality of Life Questionnaires C30 and CR29. Participants were randomly allocated to 3 groups: classical foot massage, reflexology, and standard care control. The classical massage group received foot massage using classical massage techniques, and the reflexology group received foot reflexology focusing on symptom‐oriented reflexes twice a week during a 5‐week chemoradiotherapy treatment schedule. The control group received neither classical massage nor reflexology. All patients were provided with the same clinic routine care. The classical massage was effective in reducing pain level and distension incidence while foot reflexology was effective in reducing pain and fatigue level, lowering incidence of distension and urinary frequency and improving life quality.
Climate determinants of breeding and wintering ranges of lesser kestrels in Italy and predicted impacts of climate change
Authors: Morganti Michelangelo , Preatoni Damiano , Sarà Maurizio 
Published: February 2017

Climate warming would theoretically create conditions for the breeding range expansion of pseudo‐steppe Mediterranean and long‐distance migrant species and provide the possibility for these to overwinter in the same breeding areas. However, contemporary changes in rainfall regimes might have negative effects on the climate suitability and in turn, shrink species potential range. The lesser kestrel Falco naumanni is highly sensitive to rainfall oscillations and has recently extended its Italian breeding range towards northern latitudes and increasing its wintering records. We modelled the effects of temperature and rainfall on current and future climate suitability for lesser kestrels in both the breeding and wintering periods by using MaxEnt. Models were based on the distribution of 298 colonies and 40 wintering records. Future climate suitability was assessed under eight different scenarios.Spring rainfall amount resulted as the main determinant of breeding climate suitability, so its predicted reduction will determine a shrinkage in suitable areas (–42.10% in 2050; –32.07% in 2070). Specifically, the 66.05% of Italian colonies will be outside the climatically suitable area by 2050. However wide areas, suitable under current climate conditions, are still not occupied by lesser kestrel and allow the potential expansion of its Italian breeding range in the short term. Temperature seasonality mainly determined the species’ winter climate suitability, which is overall predicted to boost in the next decades (+145.03% in 2050; and +123.91% in 2070). All but one future scenarios predicted a northward shift of about 40 km for both breeding and wintering climate suitability. Despite its recent expansion, we have found that climate change will pose conservation concerns for the Italian breeding population of lesser kestrels. Indeed, changes in non‐climate factors will also outline the future suitability of the Italian range for lesser kestrels in both seasons with effects that might both strengthen or mitigate climate effects.
End‐stage renal disease and adherence to angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers among patients with diabetes
Authors: Shani Michal , Vinker Shlomo , Feldman Leonid 
Published: February 2017

Angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have become standards of care for diabetic nephropathy. The authors assessed the association between treatment adherence to ACEIs and ARBs and the development of end‐stage renal disease (ESRD). The cohort comprised the 9895 members of the Central District of Clalit Health Services aged 40 to 70 years, diagnosed with diabetes before 2002, who filled at least four ACEI or ARB monthly prescriptions during 2002–2011. Forty‐six percent of patients made 10 or more purchases a year. Hazard ratios for ESRD development and death decreased as adherence increased, with no evidence of a cutoff threshold or plateau. For both outcomes, hazard ratios were significantly lower among patients who purchased at least 10 monthly prescriptions (83% adherence), after adjusting for age, sex, and a number of clinically relevant factors. While ACEIs/ARBs have become standards of care in diabetes, treatment adherence is essential to achieve full benefit.
Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8
Authors: Pu Yinfei , Wang Mengke , Hong Yingying , Wu Yuwei , Tang Zhihui 
Published: February 2017

AbstractAdiponectin (APN) is known to promote the osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (h‐JBMMSCs). However, the underlying mechanism has not been fully elucidated. Previously, we showed that APN could promote h‐JBMMSC osteogenesis via APPL1‐p38 by up‐regulating osteogenesis‐related genes. Here, we aimed to determine whether APN could promote h‐JBMMSC chemotaxis through CXCL1/CXCL8. The CCK‐8, wound healing and transwell assays were used to evaluate the proliferation, migration and chemotaxis of h‐JBMMSCs with or without APN treatment. Chemotaxis‐related genes were screened using RNA‐seq, and the results were validated using real‐time PCR and ELISA. We also performed Western blot using the AMPK inhibitor, WZ4003, and the p38 MAPK inhibitor, SB203580, to identify the signalling pathway involved. We found that APN could promote h‐JBMMSC chemotaxis in the co‐culture transwell system. CXCL1 and CXCL8 were screened and confirmed as the up‐regulated target genes. The APN‐induced CXCL1/8 up‐regulation to promote chemotaxis could be blocked by CXCR2 inhibitor SB225002. Western blot revealed that the phosphorylation of AMPK and p38 MAPK increased in a time‐dependent manner with APN treatment. Additionally, WZ4003 and SB203580 could suppress the APN‐induced overexpression of CXCL1 and CXCL8. The results of the transwell chemotaxis assay also supported the above results. Our data suggest that APN can promote h‐JBMMSC chemotaxis by up‐regulating CXCL1 and CXCL8.
Diabetes management and daily functioning burden of non‐severe hypoglycemia in Japanese people treated with insulin
Authors: Ohashi Yasuo , Wolden Michael L , Hyllested‐Winge Jacob , Brod Meryl 
Published: February 2017

AbstractAims/IntroductionThe present study investigated the impact of non‐severe hypoglycemic events (NSHE) on patients’ diabetes management, daily functioning and well‐being.Materials and MethodsA survey assessing the impact of NSHEs was completed by insulin‐treated Japanese people with diabetes, aged ≥20 years with self‐reported diabetes, who had experienced at least one NSHE in the past 3 months. Survey questions captured reasons for and the length of the event, and impacts on diabetes management, daily functioning, sleep and well‐being.ResultsA total of 3,145 people with type 1 diabetes mellitus and type 2 diabetes mellitus were screened, of which 411 respondents were eligible. Increased glucose monitoring was reported by 57 and 54% of respondents after daytime and night‐time NSHE, respectively. The average number of additional glucose monitoring tests was 2.4 and 3.0 for daytime and night‐time NSHE. Among all respondents, 19% (daytime) and 16% (night‐time) changed their insulin dose after an NSHE. After a daytime NSHE, 25% of respondents reported a negative impact on their daily activities or work. After a night‐time NSHE, 34 and 23% of respondents reported a negative impact on sleep and next day emotional state, respectively.ConclusionsNSHEs have a negative impact on the diabetes management, daily functioning, sleep and well‐being of Japanese patients.
Quality assessment of palliative home care in Italy
Authors: Scaccabarozzi Gianlorenzo , Lovaglio Pietro Giorgio , Limonta Fabrizio , Floriani Maddalena , Pellegrini Giacomo 
Published: February 2017

AbstractRationaleThe complexity of end‐of‐life care, represented by a large number of units caring for dying patients, of different types of organizations motivates the importance of measure the quality of provided care. Despite the law 38/2010 promulgated to remove the barriers and provide affordable access to palliative care, measurement, and monitoring of processes of home care providers in Italy has not been attempted.Aims and objectivesUsing data drawn by an institutional voluntary observatory established in Italy in 2013, collecting home palliative care units caring for people between January and December 2013, we assess the degree to which Italian home palliative care teams endorse a set of standards required by the 38/2010 law and best practices as emerged from the literature.MethodsThe evaluation strategy is based on Rasch analysis, allowing to objectively measuring both performances of facilities and quality indicators' difficulty on the same metric, using 14 quality indicators identified by the observatory's steering committee.ResultsGlobally, 195 home care teams were registered in the observatory reporting globally 40 955 cured patients in 2013 representing 66% of the population of home palliative care units active in Italy in 2013.Rasch analysis identifies 5 indicators (“interview” with caregivers, continuous training provided to medical and nursing staff, provision of specialized multidisciplinary interventions, psychological support to the patient and family, and drug supply at home) easy to endorse by health care providers and 3 problematic indicators (presence of a formally established Local Network of Palliative care in the area of reference, provision of the care for most problematic patient requiring high intensity of the care, and the percentage of cancer patient dying at Home).ConclusionsThe lack of Local Network of Palliative care, required by law 38/2010, is, at the present, the main barrier to its application. However, the adopted methodology suggests that a clear roadmap for health facilities to afford future quality and normative challenges.
Activity of paracin C from lactic acid bacteria against Alicyclobacillus in apple juice: Application of a novelty bacteriocin
Authors: Pei Jinjin , Yue Tianli , Yuan Yahong , Dai Lu 
Published: February 2017

AbstractOne of the common bacteria to cause spoiling of fruit juices, is Alicyclobacillus acidoterrestris. Control of A. acidoterrestris in apple juice by paracin C, a bacteriocin produced by Lactobacillus paracasei CICC 20241, has been described in the present work. The spectrum of paracin C activity was investigated which resulted in identification of seventeen strains of A. acidoterrestris as sensitive. Bacteriocin absorption to different A. acidoterrestris resulted in variations based on differences in strain and testing environments Increase in absorption was observed with increasing temperature while it decreased with increasing pH. Presence of NaCl (1%) propelled the absorption of bacteriocin while Tween 20 and Tween 80 reduced the absorption. Results of electron microscopy examination clearly pointed out extensive cell damage and destruction of bacteria on treatment with bacteriocin. Although the endospores cannot be killed by paracin C in apple juice, upon addition of this bacterioicin, reduction in the thermal resistance of A. acidoterrestris spores was clearly observed. There was no unpalatable favor when the addition of paracin C was less than 100 μg/ml.Practical uses–actual or potential–of the researchOne of the common bacteria to cause spoiling of fruit juices, is Alicyclobacillus acidoterrestris. The heat resistance capacity in its spores is very high and the normally pasteurization in industry may not be able to kill all the spores. This situation calls for development of an effective method to control the germination and outgrowth of Alicyclobacillus acidoterrestris and it is an urgent need in the beverage industries. Traditional chemical preservatives may be harmful to health if used in over‐dose or in long‐time use. Paracin C produced by Lactobacillus paracasei CICC 20241 is a safe and efficient bacteriocin active against A. acidoterrestris. It is able to inhibit and kill the cells of A. acidoterrestris present in apple juice and has a broad activity spectrum. These factors along with other characterization made it a promising potential preservative in apple juice industrial.
PTSD, Psychotropic Medication Use, and the Risk of Dementia Among US Veterans: A Retrospective Cohort Study
Authors: Mawanda Francis , Wallace Robert B. , McCoy Kimberly , Abrams Thad E. 
Published: February 2017

ObjectiveTo determine the associations between PTSD, psychotropic medication use, and the risk for dementia.DesignRetrospective cohort.ParticipantsNationwide sample of US veterans (N = 417,172) aged ≥56 years during fiscal year (FY) 2003 without a diagnosis of dementia or mild cognitive impairment at baseline (FY02‐03) and ≥1 clinical encounter every 2 years during follow‐up (FY04‐12).MeasuresDemographic characteristics; diagnosis of PTSD, dementia, and medical and psychiatric comorbidity (defined by ICD‐9 codes); and psychotropic medication use including selective serotonin reuptake inhibitors (SSRI), serotonin‐norepinephrine reuptake inhibitors (SNRI), novel antidepressants (NA), benzodiazepines (BZA), and atypical antipsychotics (AA). Cox proportional hazard models examined for associations between PTSD diagnosis, psychotropic medication use, and risk for a dementia diagnosis.ResultsPTSD diagnosis significantly increased the risk for dementia diagnosis (HR = 1.35; [95% CI = 1.27–1.43]). However, there were significant interactions between PTSD diagnosis and use of SSRIs (P < .001), NAs (P = .014), and AAs (P < .001) on the risk for dementia diagnosis. HR for dementia diagnosis among veterans diagnosed with PTSD and not using psychotropic medications was 1.55 [1.45–1.67]. Among veterans diagnosed with PTSD prescribed SSRI, SNRI, or AA, HR for dementia diagnosis varied by drug class use ranging from 1.99 for SSRI to 4.21 for AA, relative to veterans without a PTSD diagnosis and no psychotropic medication receipt. BZAs or SNRIs use at baseline was associated with a significantly increased risk for dementia diagnosis independent of a PTSD diagnosis.ConclusionPTSD diagnosis is associated with an increased risk for dementia diagnosis that varied with receipt of psychotropic medications. Further research would help to delineate if these findings are due to differences in PTSD severity, psychiatric comorbidity, or independent effects of psychotropic medications on cognitive decline.