bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Oral Contraceptives to Manipulate Menstruation in Young, Physically Active Women
Authors: Schaumberg Mia A. , Emmerton Lynne M. , Jenkins David G. , Burton Nicola W. , Janse de Jonge Xanne A.K. , Skinner Tina L. 
Published: May 2017

Purpose: Menstruation and menstrual symptoms are commonly cited barriers to physical activity in women. The delay or avoidance of menstruation through extended oral-contraceptive (OC) regimens may mitigate these barriers, yet information on menstrual-manipulation practices in young physically active women is sparse. The objective of this study was to investigate prevalence of, and reasons for, menstrual manipulation with OCs in recreationally and competitively active women. Methods: One hundred ninety-one recreationally active (self-reported moderate to vigorous physical activity 150–300 min/wk) women (age 23 ± 5 y), 160 subelite recreationally active (self-reported moderate to vigorous physical activity >300 min/wk) women (age 23 ± 5 y), and 108 competitive (state-, national- or international-level) female athletes (age 23 ± 4 y) completed a self-administered questionnaire assessing OC-regimen habits and reasons for manipulation of menstruation. Results: The majority (74%) of OC users reported having deliberately manipulated menstruation at least once during the previous year, with 29% reporting having done so at least 4 times. Prevalence of menstrual manipulation (at least once in the previous year) was not different between competitive athletes, subelite recreationally active women, and recreationally active women (77% vs 74% vs 72%; P > .05). The most cited reasons for manipulating menstruation were special events or holidays (rated by 75% as important/very important), convenience (54%), and sport competition (54%). Conclusions: Menstrual manipulation through extended OC regimens is common practice in recreationally and competitively active young women, for a range of reasons relating to convenience that are not limited to physical activity. This strategy may help reduce hormone-related barriers to exercise participation, thereby positively affecting participation and performance.
Reliability of Power Settings of the Wahoo KICKR Power Trainer After 60 Hours of Use
Authors: Zadow Emma K. , Kitic Cecilia M. , Wu Sam S.X. , Fell James W. 
Published: May 2017

Purpose: To assess the reliability of power-output measurements of a Wahoo KICKR Power Trainer (KICKR) on 2 separate occasions separated by 14 mo of regular use (∼1 h/wk). Methods: Using the KICKR to set power outputs, powers of 100–600 W in increments of 50 W were assessed at cadences of 80, 90, and 100 rpm that were controlled and validated by a dynamic calibration rig. Results: A small ratio bias of 1.002 (95% limits of agreement [LoA] 0.992–1.011) was observed over 100–600 W at 80–100 rpm between trials 1 and 2. Similar ratio biases with acceptable limits of agreement were observed at 80 rpm (1.003 [95% LoA 0.987–1.018]), 90 rpm (1.000 [0.996–1.005]), and 100 rpm (1.002 [0.997–1.007]). The intraclass correlation coefficient with 95% confidence interval (CI) for mean power between trials was 1.00 (95% CI 1.00–1.00) with a typical error (TE) of 3.1 W and 1.6% observed between trials 1 and 2. Conclusion: When assessed at 2 separate time points 14 mo apart, the KICKR has acceptable reliability for combined power outputs of 100–600 W at 80–100 rpm, reporting overall small ratio biases with acceptable LoA and low TE. Coaches and sport scientists should feel confident in the power output measured by the KICKR over an extended period of time when performing laboratory training and performance assessments.
Anthropometric Profiles of Elite Open-Water Swimmers
Authors: Shaw Gregory , Mujika Iñigo 
Published: May 2017

Reports detailing the physiques of open-water (OW) swimmers are limited. Data from anthropometric screening around competition provides a unique opportunity to describe the current physical attributes of elite OW swimmers peaking for international competition. Anthropometric screening was undertaken on a group of Australian and French OW swimmers as part of performance monitoring within 2 wk of the 2015 FINA World Championships. Height, mass, and sum of 7 skinfolds were measured using ISAK standardized measurement techniques by 2 trained anthropometrists. Data were collated and compared with previously published data on OW and pool swimmers. French swimmers had lower skinfolds (57.3 ± 6.1 vs 80.5 ± 21.3 mm, P = .0258), were lighter (64.7 ± 10.8 vs 74.6 ± 11.8 kg, P = .013), and had lower lean-mass index (LMI) (34.7 ± 7.3 vs 38.2 ± 8.8, P = .035) than Australian swimmers. Male and female OW swimmers had skinfolds similar to their contemporary OW swimmers but were lower than earlier reports of OW swimmers; however, they were higher than those of pool swimmers. Male and female OW swimmers had 9% and 6% lower LMI, respectively, than pool swimmers. Lower body mass and LMI were correlated with better World Championships finishing positions (R2 = .46, P = .0151, and R2 = .45, P = .0177, respectively). These data are a unique report of elite OW swimmers’ physiques around international competition and demonstrate a potential morphological optimization in OW swimmers that warrants further investigation in larger populations.
Characteristics and Challenges of Open-Water Swimming Performance: A Review
Authors: Baldassarre Roberto , Bonifazi Marco , Zamparo Paola , Piacentini Maria Francesca 
Published: May 2017

Context:Although the popularity of open-water swimming (OWS) events has significantly increased in the last decades, specific studies regarding performance of elite or age-group athletes in these events are scarce.Purpose:To analyze the existing literature on OWS.Methods:Relevant literature was located via computer-generated citations. During August 2016, online computer searches on PubMed and Scopus databases were conducted to locate published research.Results:The number of participants in ultraendurance swimming events has substantially increased in the last 10 y. In elite athletes there is a higher overall competitive level of women than of men. The body composition of female athletes (different percentage and distribution of fat tissue) shows several advantages (more buoyancy and less drag) in aquatic conditions that determine the small difference between males and females. The main physiological characteristics of open-water swimmers (OW swimmers) are the ability to swim at high percentage of (80–90%) for many hours. Furthermore, to sustain high velocity for many hours, endurance swimmers need a high propelling efficiency and a low energy cost.Conclusion:Open-water races may be characterized by extreme environmental conditions (water temperature, tides, currents, and waves) that have an overall impact on performance, influencing tactics and pacing. Future studies are needed to study OWS in both training and competition.
Class-Related Emotions in Secondary Physical Education: A Control-Value Theory Approach
Authors: Simonton Kelly L. , Garn Alex C. , Solmon Melinda Ann 
Published: May 2017

Purpose:Grounded in control-value theory, a model of students’ achievement emotions in physical education (PE) was investigated.Methods:A path analysis tested hypotheses that students’ (N = 529) perceptions of teacher responsiveness, assertiveness, and clarity predict control and value beliefs which, in turn, predict enjoyment and boredom.Results:Teacher clarity predicted student control (β = .31; R2= .09) and value (β = .21; R2= .07) beliefs. Value and control beliefs positively predicted enjoyment (β = .71; β = .11; R2 = .58) and negatively predicted boredom (β = -.61; β = -.13; R2 = .47).Discussion:Findings provide meaningful information about the source of students’ emotional experiences in PE. The importance of instructional clarity within the model highlights the need for teachers to use a variety of clarifying strategies during instruction. The strong links between value beliefs and emotions suggest teachers need to explicitly discuss the intrinsic and extrinsic worth of PE content.
Understanding Physical Education Doctoral Students’ Perspectives of Socialization
Authors: Richards K. Andrew R. , McLoughlin Gabriella M. , Ivy Victoria Nicole , Gaudreault Karen Lux 
Published: May 2017

Purpose:Despite an abundance of research on doctoral student socialization in higher education, little attention has been paid to physical education doctoral students. This study sought to understand physical education doctoral students’ perceptions of their socialization as preparation for faculty roles.Method:Participants included 32 physical education doctoral students (16 female, 16 male) from US institutions of higher education. Data were collected in three phases using focus group interviews, an open-ended survey, and individual interviews.Results:Three first-order themes described: (a) indirect, but common pathways to pursuing a doctoral degree, (b) relationships are essential to the doctoral program experience, and (c) becoming a faculty member is a complex and ongoing process.Discussion/Conclusions:Relationships, particularly with faculty members, are integral to doctoral education. Training for the role of doctoral advisor could be beneficial, as could connecting cohort members and promoting opportunities to learn the role of teacher educator and publish research.
The Role of Perceived and Actual Motor Competency on Children’s Physical Activity and Cardiorespiratory Fitness During Middle Childhood
Authors: Gu Xiangli , Thomas Katherine Thomas , Chen Yu-Lin 
Published: May 2017

Purpose:Guided by Stodden et al.’s (2008) conceptual model, the purpose of this study was to examine the associations among perceived competence, actual motor competence (MC), physical activity (PA), and cardiorespiratory fitness in elementary children. The group differences were also investigated as a function of MC levels.Methods:A correlational research design was used in this study. There were 262 children (Mage = 10.87, SD = .77) recruited from three schools in the southern U.S. Students’ MC was objectively measured based on a process-oriented assessment (PE Metrics, NASPE, 2010). Students self-reported perceived competence and leisure-time PA. Then, the Progressive Aerobic Cardiovascular Endurance Run (PACER) and pedometers were used to measure students’ cardiorespiratory fitness and in-class PA, respectively.Results:The structural equation modeling analysis supported the significant indirect effect of the MC on cardiorespiratory fitness and PA through perceived competence. The MANCOVA yielded a significant main effect for MC groups after controlling for sex [Wilks’s Lambda = .838, F = 12.15 (4, 251), p < .001, η2 = .16]. Regardless of sex, children with low MC demonstrated lower perceived competence, PA, and cardiorespiratory fitness compared with children with higher MC (p < .001).Discussion:Development of students’ competence beliefs in PE and certain movement patterns should be emphasized, especially during middle childhood. High quality PE programs must be aligned with national standards, with particular attention to enhancing skill acquisition (standard 1) and PE-motivation (i.e., perceived competence; standard 5).
Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor
Authors: Wang Yaxin , Cao Lin , Zhai Yangyang , Yin Zheng , Sun Yuna , Shang Luqing 
Published: May 2017

ABSTRACT

Hand-foot-and-mouth disease (HFMD), caused by enterovirus, is a threat to public health worldwide. To date, enterovirus 71 (EV71) has been one of the major causative agents of HFMD in the Pacific-Asia region, and outbreaks with EV71 cause millions of infections. However, no drug is currently available for clinical therapeutics. In our previous works, we developed a set of protease inhibitors (PIs) targeting the EV71 3C protease (3C
pro
). Among these are NK-1.8k and NK-1.9k, which have various active groups and high potencies and selectivities. In the study described here, we determined the structures of the PI NK-1.8k in complex with wild-type (WT) and drug-resistant EV71 3C
pro
. Comparison of these structures with the structure of unliganded EV71 3C
pro
and its complex with AG7088 indicated that the mutation of N69 to a serine residue destabilized the S2 pocket. Thus, the mutation influenced the cleavage activity of EV71 3C
pro
and the inhibitory activity of NK-1.8k in an
in vitro
protease assay and highlighted that site 69 is an additional key site for PI design. More information for the optimization of the P1′ to P4 groups of PIs was also obtained from these structures. Together with the results of our previous works, these in-depth results elucidate the inhibitory mechanism of PIs and shed light to develop PIs for the clinical treatment of infections caused by EV71 and other enteroviruses.
Circulating Tumor Cells with Aberrant ALK Copy Number Predict Progression-Free Survival during Crizotinib Treatment in ALK-Rearranged Non–Small Cell Lung Cancer Patients
Authors: Pailler Emma , Oulhen Marianne , Borget Isabelle , Remon Jordi , Ross Kirsty , Auger Nathalie , Billiot Fanny , Ngo Camus Maud , Commo Frédéric , Lindsay Colin R. , Planchard David , Soria Jean-Charles , Besse Benjamin , Farace Françoise 
Published: May 2017

Abstract
The duration and magnitude of clinical response are unpredictable in ALK-rearranged non–small cell lung cancer (NSCLC) patients treated with crizotinib, although all patients invariably develop resistance. Here, we evaluated whether circulating tumor cells (CTC) with aberrant ALK-FISH patterns [ALK-rearrangement, ALK-copy number gain (ALK-CNG)] monitored on crizotinib could predict progression-free survival (PFS) in a cohort of ALK-rearranged patients. Thirty-nine ALK-rearranged NSCLC patients treated with crizotinib as first ALK inhibitor were recruited prospectively. Blood samples were collected at baseline and at an early time-point (2 months) on crizotinib. Aberrant ALK-FISH patterns were examined in CTCs using immunofluorescence staining combined with filter-adapted FISH after filtration enrichment. CTCs were classified into distinct subsets according to the presence of ALK-rearrangement and/or ALK-CNG signals. No significant association between baseline numbers of ALK-rearranged or ALK-CNG CTCs and PFS was observed. However, we observed a significant association between the decrease in CTC number with ALK-CNG on crizotinib and a longer PFS (likelihood ratio test, P = 0.025). In multivariate analysis, the dynamic change of CTC with ALK-CNG was the strongest factor associated with PFS (HR, 4.485; 95% confidence interval, 1.543–13.030, P = 0.006). Although not dominant, ALK-CNG has been reported to be one of the mechanisms of acquired resistance to crizotinib in tumor biopsies. Our results suggest that the dynamic change in the numbers of CTCs with ALK-CNG may be a predictive biomarker for crizotinib efficacy in ALK-rearranged NSCLC patients. Serial molecular analysis of CTC shows promise for real-time patient monitoring and clinical outcome prediction in this population. Cancer Res; 77(9); 2222–30. ©2017 AACR.
The Alexandrian Footnote in Lucretius’ De Rerum Natura
Authors: Nethercut Jason S. 
Published: May 2017

Abstract
This paper contributes evidence to support the widely accepted view that Lucretius may justly be regarded by the reader as a Callimachean poet by synthesizing and analyzing Lucretius’ use of the so-called ‘Alexandrian footnote’ in the DRN. Although most scholars have come to agree with Kenney that Lucretius embraces many of the same poetic ideals as his contemporaries, there are still some who remain skeptical of Kenney’s thesis, and, while Kenney adduces the most prominent parts of the DRN that show signs of Alexandrianism, in fact he only scratches the surface of the extent to which Lucretius practices his own version of Roman neo-Callimacheanism. Moreover, very few of those who accept Kenney’s results have followed his lead by adding corroborating evidence. It is still very much worthwhile, therefore, to explore this aspect of Lucretius’ poetic artistry; this paper’s analysis of the Alexandrian footnote provides further proof that Kenney’s argument is correct, and it expands on his thesis by showing how integral Alexandrian poetic techniques are to Lucretius’ philosophical purposes.
Climatology of Tropical Overshooting Tops in North Atlantic Tropical Cyclones
Authors: Griffin Sarah M. 
Published: May 2017

AbstractOrganized tropical convection, often characterized by overshooting tops, is a distinguishing quality of tropical cyclones (TCs). In this study, the climatology of tropical overshooting tops (TOTs) in North Atlantic Ocean TCs from 2004 to 2015 is examined. Previous studies have investigated the distribution of convection in TCs based on lightning data. The purpose of this study is to examine the distribution of TC convection from geostationary satellites using an objective TOT detection algorithm based on infrared brightness temperatures and empirically dependent thresholds. It will be shown that TOTs can provide an additional metric for identifying the characteristics of TC convection. Based on the 12-yr (2004–15) climatology, a distinct semidiurnal cycle in TOT activity is detected within 500 km of the TC center. In agreement with lightning data from previous studies, a predawn maximum (local to the TC) in TOTs is observed within 300 km of the TC center. A second predusk maximum is associated with TOTs between 300 and 500 km of the TC center. TC intensity and intensity trend along with environmental factors can affect the number and distribution of TOTs. For example, an exponential relationship exists between the number of TOTs and increasing sea surface temperatures. Conversely, increasing vertical wind shear magnitude decreases the density of TOTs, with a higher percentage of TOTs observed downshear of the wind direction. Generally, within 100 km (100–300 km) of the TC center, the preferred quadrant for TOTs is downshear left (downshear right), and increased TOT activity is observed right of TC motion. The findings corroborate previous lightning study results while providing additional insights into TC convection.
Changes in Ocean Temperature in the Barents Sea in the Twenty-First Century
Authors: Long Zhenxia , Perrie Will 
Published: May 2017

AbstractPossible modifications to ocean temperature in the Barents Sea induced by climate change are explored. The simulations were performed with a coupled ice–ocean model (CIOM) driven by the surface fields from the Canadian Regional Climate Model (CRCM) simulations. CIOM can capture the observed water volume inflow through the Barents Sea Opening. The CIOM simulation and observations suggest an increase in the Atlantic water volume inflow and heat transport into the Barents Sea in recent decades resulting from enhanced storm activity. While seasonal variations of sea ice and sea surface temperature in CIOM simulations are comparable with observations, CIOM results underestimate the sea surface temperature but overestimate ice cover in the Barents Sea, consistent with an underestimated heat transport through the Barents Sea Opening. Under the SRES A1B scenario, the loss of sea ice significantly increases the surface solar radiation and the ocean surface heat loss through turbulent heat fluxes and longwave radiation. Meanwhile, the lateral heat transport into the Barents Sea tends to increase. Thus, changes in ocean temperature depend on the heat balance of solar radiation, surface turbulent heat flux, and lateral heat transport. During the 130-yr simulation period (1970–2099), the average ocean temperature increases from 0° to 1°C in the southern Barents Sea, mostly due to increased lateral heat transport and solar radiation. In the northern Barents Sea, ocean temperature decreases by 0.4°C from the 2010s to the 2040s and no significant trend can be seen thereafter, when the surface heat flux is balanced by solar radiation and lateral heat transport and there is no notable net heat flux change.
Genesis of Super Cyclone Pam (2015): Modulation of Low-Frequency Large-Scale Circulations and the Madden–Julian Oscillation by Sea Surface Temperature Anomalies
Authors: Nakano Masuo , Kubota Hisayuki , Miyakawa Tomoki , Nasuno Tomoe , Satoh Masaki 
Published: May 2017

AbstractSuper Cyclone Pam (2015) formed in the central tropical Pacific under conditions that included El Niño Modoki and the passage of a convectively enhanced phase of the Madden–Julian oscillation (MJO) in the western Pacific. This study examines the influence that sea surface temperature anomalies (SSTAs) have on the MJO and low-frequency large-scale circulation, and establishes how they modulated the genesis of Pam. Two series of numerical experiments were conducted by using a nonhydrostatic global atmospheric model with observed (OBSSST) and climatological (CLMSST) SSTs. The results suggested that low-frequency westerly winds at 850 hPa (U850) were intensified in the central tropical Pacific due to the observed SSTA. The amplitude of the MJO simulated in OBSSST was larger than in CLMSST. In addition, the experiments initialized 26 February–2 March exhibited that the phase of the MJO in OBSSST was ahead of that in CLMSST, and that the genesis location in OBSSST was ~10° to the east of that in CLMSST. An analysis of large-scale fields indicated that a positive U850 maintained by SSTAs and intensification of U850 by the MJO modified distribution of large-scale cyclonic vorticity and precipitable water. These changes in large-scale fields modified the location and timing of intensification of the disturbance that become Pam and resulted in Pam’s genesis location being 10° farther east with slight impact on its genesis probability. Additional experiments showed that SSTAs in the central tropical Pacific were the dominant cause of modifications to large-scale fields, the MJO, and Pam’s genesis location.
An analysis of trends in publications on ‘tobacco control’
Authors: Unutmaz Durmuşoğlu Zeynep Didem , Kocabey Çiftçi Pınar 
Published: May 2017

Objectives: Publications on tobacco control were quantitatively analysed to gain insight into the essential characteristics of the research field and trends and patterns in publication activities. The goal was to detect changes in the number of publications before and after the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) was introduced. Study design: A bibliometric analysis was performed to assess the current status and research themes of tobacco control papers listed in the Web of Science database published between 1990 and 2015. Methods: Quantitative analyses were conducted to investigate publication activities, geographic distribution and individuals’ research fields within tobacco control. Results: The number of publications on tobacco control was over 81 times higher in 2015 than in 1990. At least 50% of the papers were published by authors in high-income countries. In addition, in the first 5 years after the WHO FCTC was introduced, publications on tobacco control increased considerably and the first publications from authors from Malaysia and Uruguay appeared. Researchers from the Americas Region of WHO contributed to the field much more frequently than those from the other five WHO regions. Conclusion: Findings from this study suggest that researchers’ interest from most countries increased after the WHO FCTC was introduced. However, research outputs from low- and middle-income countries remained comparatively low. Promoting more interest in tobacco control among researchers in these countries may help control the future prevalence of smoking.