bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Computational Approach to Identify a Potential Alternative Drug With Its Positive Impact Toward PMP22
Authors: Agrahari Ashish Kumar , C George Priya Doss 
Published: April 2017

ABSTRACTMutations in the Peripheral Myelin Protein 22 (PMP22) leads to Charcot Marie Tooth type 1A (CMT1A, a subtype of CMT1) disease which is the most common inherited neuropathy of peripheral nervous system. In the present study, we used series of in silico prediction methods to screen and identify the most deleterious non‐synonymous SNPs (nsSNPs) in PMP22 gene. Out of 48 nsSNPs, five nsSNPs (L16P, L19P, T23R, W28R, and L147R) associated with PMP22 were predicted to be highly deleterious and destabilizing the protein. To explore the possible structure‐function relationship, we employed abinitio modeling strategy using the CABS‐fold server to predict the three‐dimensional structure models in the absence of crystallized structures in PMP22 protein. We used Cytoscape 3.4.0 plugin Integrated Complex Traits Networks interface (iCTNet) to identify the probable drug‐gene interactions in PMP22 gene. A total of 22 chemical compounds yielded from the aforementioned tool was subjected to Molinspiration and OSIRIS program to screen and identify the potent drug molecules for further analysis. Five chemical compounds with excellent bioavailability and drug relevant property were selected for molecular docking simulation study. We modeled five mutant structures at their corresponding positions and performed molecular docking simulation analysis using AutoDock Tools (ADT) version 1.5.6 and ArgusLab 4.0.1 tools to analyze their interaction patterns and binding efficacy. Based on the results obtained from the computational study, we predict that estradiol could be a potential drug of choice for treating patients with CMT1A which needs larger attention from biologists in the near future. J. Cell. Biochem. 118: 3730–3743, 2017. © 2017 Wiley Periodicals, Inc.
A link between platelet to lymphocyte ratio and Helicobacter pylori infection
Authors: Farah Raymond , Hamza Hamza , Khamisy‐farah Rola 
Published: April 2017

PurposeChronic Helicobacter pylori gastritis affects two‐thirds of the world's population and is one of the most common chronic inflammatory disorders of humans, the infection clearly results in chronic mucosal inflammation in the stomach and duodenum, which, in turn, might lead to abnormalities in gastroduodenal motility and sensitivity and is the most frequent cause of dyspepsia and peptic disease. Some studies showed that there was a correlation between low‐grade inflammation as CRP and HP infection. The purpose of this study was to investigate the relationship between the presence of HP infection and platelet/lymphocyte ratio (PLR).MethodA total of 200 patients who met the HP criteria and 180 age‐ and gender‐matched control subjects were included in this randomized controlled trial. Patients were diagnosed to have HP according stomach biopsy and urea breath test, PLR was calculated from complete blood count at time of diagnosis and before initiating the treatment.ResultsPatients with HP infection had significantly higher PLR compared to those without HP. Moreover, the patients with symptomatic HP had higher PLR than those with asymptomatic HP. While PLR increased as the severity of HP symptoms increased (r=.452, P<.001).ConclusionOur study indicated, for the first time, a significant association between HP infection and symptoms based on PLR, a simple and reliable indicator of inflammation. Furthermore, there an increase in PLR as the severity of HP increases.
The clinical significance of DJ‐1 and HE4 in patients with endometrial cancer
Authors: Benati Marco , Montagnana Martina , Danese Elisa , Paviati Elisa , Giudici Silvia , Ruzzenente Orazio , Franchi Massimo , Lippi Giuseppe 
Published: April 2017

BackgroundThe non‐invasive diagnostic approach for early detection of endometrial cancer (EC) remains limited. To date, human epididymis protein 4 (HE4) has been intensively studied but its diagnostic is controversial in EC. DJ‐1 is an oncoprotein secreted by cancer cells, recently identified as a potential diagnostic biomarker for breast cancer, melanoma, and pancreatic cancer. The aim of this study was to compare the diagnostic performances of DJ‐1 and HE4 measured in EC patients and healthy controls (HC).MethodsForty‐five patients (63.9±12.0 years) with EC and 29 (63.2±13.3 years) HC were enrolled. Serum concentrations of DJ‐1 and HE4 were measured using ELISA kits developed by R&D (Minneapolis, USA) and Fujirebio Diagnostic (Malvern, PA, USA), respectively. Differences between EC patients and HC were assessed by Mann‐Whitney test and associations were tested by Spearman's correlation. The diagnostic performance was assessed using receiver operating characteristics (ROC) curves analysis.ResultsSerum DJ‐1 concentrations were found to be higher in EC patients than in HC (9533.6 vs 1988.5 pg/mL; P<.0001). The area under the ROC curve (ROC‐AUC) was 0.95 (P<.0001). At the cut‐off of 3654 pg/mL, the sensitivity and specificity were 0.89 and 0.90, respectively. HE4 serum levels were higher in EC patients than in HC (75.3 vs 56.2 pmol/L; P=.019), with an AUC of 0.66 (P=.020). The AUC obtained by the combination of the two markers resulted 0.96 (P<.0001).ConclusionThese results suggest that increased serum DJ‐1 levels are associated with EC and that this biomarker may be potentially useful for diagnosing EC.
Antimuscarinic Use in Females With Overactive Bladder Syndrome Increases the Risk of Depressive Disorder: A 3‐Year Follow‐up Study
Authors: Chung Shiu‐Dong , Weng Sung‐Shun , Huang Chao‐Yuan , Lin Herng‐Ching , Kao Li‐Ting 
Published: April 2017

AbstractTo date, the relationship between antimuscarinics for overactive bladder (OAB) syndrome and depressive disorder still remains unclear. Therefore, this retrospective cohort study examined the association between antimuscarinic use and the subsequent risk of depressive disorder using a population‐based data set. This study used data from the Taiwan Longitudinal Health Insurance Database 2005. We selected 1952 OAB women who received antimuscarinics as the study cohort and 9760 OAB women who did not receive antimuscarinics as the comparison cohort. Each subject was tracked for 3 years from her index date to determine all those who were subsequently diagnosed with depressive disorder. Results indicated that the adjusted hazard ratio (HR) for depressive disorder in OAB women who received antimuscarinics was 1.38 (95% confidence interval [CI], 1.15–1.64) compared with those OAB women who did not receive antimuscarinics. In addition, the adjusted HRs for subsequent depressive disorder for OAB women aged 18–39, 40–59, and ≥60 years who received antimuscarinics were 1.83 (95%CI, 1.27–2.64), 1.36 (95%CI, 1.03–1.81), and 1.16 (95%CI, 0.86–1.56), respectively, compared with those OAB women who did not receive antimuscarinics. We concluded that women with OAB who received antimuscarinics had a significantly higher risk of subsequent depressive disorder compared with those OAB women who did not receive antimuscarinics. Accordingly, clinicians should be alert to the relationship between antimuscarinics usage and depressive disorder in OAB women and provide appropriate instructions for these patients.
Sonographic evaluation of the fetal spine position and success rate of manual rotation of the fetus in occiput posterior position: A randomized controlled trial
Authors: Masturzo Bianca , Farina Antonio , Attamante Lorenza , Piazzese Annalisa , Rolfo Alessandro , Gaglioti Pietro , Todros Tullia 
Published: April 2017

ABSTRACTBackgroundTo evaluate whether sonographic (US) diagnosis of the fetal spine position could increase the success rate of manual rotation of the fetal occiput (MRFO) in second‐stage arrest in persistent occiput posterior position (OPP).MethodsIn this randomized controlled parallel single‐center trial, 58 nulliparous in second‐stage arrest of labor with fetus in cephalic presentation and OPP diagnosed by US were randomly assigned to group A where the fetal spine position was not known by the operator or to group B where the operator knew it. The main outcome was the success of MRFO in the two groups. Secondary outcomes were perineal injuries, blood loss, duration of expulsive period, and neonatal APGAR at 5 minutes.ResultsA priori knowledge of the spine position improves the success of the MRFO (41.4% group A versus 82.8% group B, p value < 0.001), the percentage of spontaneous deliveries (27.6% group A versus 69% group B, p value = 0.01), and maternal outcome (intact perineum and blood loss). No differences were detected on the neonatal side.ConclusionsMRFO is a safe and useful procedure that should be performed in second‐stage arrest in OPP. A better performance was observed when supported by the US knowledge of the spine position. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:472–476, 2017
Travel medicine: Part 1–The basics
Authors: Kamata Kazuhiro , Birrer Richard B , Tokuda Yasuharu 
Published: April 2017

AbstractInternational travels for tourism and business purposes continue to increase annually, while the global terrorism and the risk of lethal viral infections are currently real concerns. It is important that primary care physicians assess travel risk and adequately prepare the prospective traveler for trips. Appropriate vaccines should be administered and an emergency self‐kit recommended. Patient should be educated about safe travel habits and a posttravel follow‐up process established. Further, traveling healthcare professionals may be called upon to assist an ill patient at any time during their journey. In these 2‐part special articles, we provide a practical brief summary of up‐to‐date travel medicine basics for primary care physicians.
Computer‐aided heterogeneity analysis in breast MR imaging assessment of ductal carcinoma in situ: Correlating histologic grade and receptor status
Authors: Chou Shinn‐Huey S. , Gombos Eva C. , Chikarmane Sona A. , Giess Catherine S. , Jayender Jagadeesan 
Published: April 2017

PurposeTo identify breast MR imaging biomarkers to predict histologic grade and receptor status of ductal carcinoma in situ (DCIS).Materials and MethodsInformed consent was waived in this Health Insurance Portability and Accountability Act‐compliant Institutional Review Board‐approved study. Case inclusion was conducted from 7332 consecutive breast MR studies from January 1, 2009, to December 31, 2012. Excluding studies with benign diagnoses, studies without visible abnormal enhancement, and pathology containing invasive disease yielded 55 MR‐imaged pathology‐proven DCIS seen on 54 studies. Twenty‐eight studies (52%) were performed at 1.5 Tesla (T); 26 (48%) at 3T. Regions‐of‐interest representing DCIS were segmented for precontrast, first and fourth postcontrast, and subtracted first and fourth postcontrast images on the open‐source three‐dimensional (3D) Slicer software. Fifty‐seven metrics of each DCIS were obtained, including distribution statistics, shape, morphology, Renyi dimensions, geometrical measure, and texture, using the 3D Slicer HeterogeneityCAD module. Statistical correlation of heterogeneity metrics with DCIS grade and receptor status was performed using univariate Mann‐Whitney test.ResultsTwenty‐four of the 55 DCIS (44%) were high nuclear grade (HNG); 44 (80%) were estrogen receptor (ER) positive. Human epidermal growth factor receptor‐2 (HER2) was amplified in 10/55 (18%), nonamplified in 34/55 (62%), unknown/equivocal in 8/55 (15%). Surface area‐to‐volume ratio showed significant difference (P < 0.05) between HNG and non‐HNG DCIS. No metric differentiated ER status (0.113 < p ≤ 1.000). Seventeen metrics showed significant differences between HER2‐positive and HER2‐negative DCIS (0.016 < P < 0.050).ConclusionQuantitative heterogeneity analysis of DCIS suggests the presence of MR imaging biomarkers in classifying DCIS grade and HER2 status. Validation with larger samples and prospective studies is needed to translate these results into clinical applications.Level of Evidence: 3Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2017;46:1748–1759.
Comparison between types I and II epithelial ovarian cancer using histogram analysis of monoexponential, biexponential, and stretched‐exponential diffusion models
Authors: Wang Feng , Wang Yuxiang , Zhou Yan , Liu Congrong , Xie Lizhi , Zhou Zhenyu , Liang Dong , Shen Yang , Yao Zhihang , Liu Jianyu 
Published: April 2017

PurposeTo evaluate the utility of histogram analysis of monoexponential, biexponential, and stretched‐exponential models to a dualistic model of epithelial ovarian cancer (EOC).Materials and MethodsFifty‐two patients with histopathologically proven EOC underwent preoperative magnetic resonance imaging (MRI) (including diffusion‐weighted imaging [DWI] with 11 b‐values) using a 3.0T system and were divided into two groups: types I and II. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient (DDC), and intravoxel water diffusion heterogeneity (α) histograms were obtained based on solid components of the entire tumor. The following metrics of each histogram were compared between two types: 1) mean; 2) median; 3) 10th percentile and 90th percentile. Conventional MRI morphological features were also recorded.ResultsSignificant morphological features for predicting EOC type were maximum diameter (P = 0.007), texture of lesion (P = 0.001), and peritoneal implants (P = 0.001). For ADC, D, f, DDC, and α, all metrics were significantly lower in type II than type I (P < 0.05). Mean, median, 10th, and 90th percentile of D* were not significantly different (P = 0.336, 0.154, 0.779, and 0.203, respectively). Most histogram metrics of ADC, D, and DDC had significantly higher area under the receiver operating characteristic curve values than those of f and α (P < 0.05)ConclusionIt is feasible to grade EOC by morphological features and three models with histogram analysis. ADC, D, and DDC have better performance than f and α; f and α may provide additional information.Level of Evidence: 4Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2017;46:1797–1809.
7T: Physics, safety, and potential clinical applications
Authors: Kraff Oliver , Quick Harald H. 
Published: April 2017

With more than 60 installed magnetic resonance imaging (MRI) systems worldwide operating at a magnetic field strength of 7T or higher, ultrahigh‐field (UHF) MRI has been established as a platform for clinically oriented research in recent years. Profound technical and methodological developments have helped overcome the inherent physical challenges of UHF radiofrequency (RF) signal homogenization in the human body. The ongoing development of dedicated RF coil arrays was pivotal in realizing UHF body MRI, beyond mere brain imaging applications. Another precondition to clinical application of 7T MRI is the safety testing of implants and the establishment of safety concepts. Against this backdrop, 7T MRI and MR spectroscopy (MRS) recently have demonstrated capabilities and potentials for clinical diagnostics in a variety of studies. This article provides an overview of the immanent physical challenges of 7T UHF MRI and discusses recent technical solutions and safety concepts. Furthermore, recent clinically oriented studies are highlighted that span a broad application spectrum from 7T UHF brain to body MRI.Level of Evidence: 4Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2017;46:1573–1589.
Lifecycle of South American Monsoon System simulated by CPTEC/INPE AGCM
Authors: Cavalcanti Iracema Fonseca de Albuquerque , Raia Adma 
Published: April 2017

ABSTRACTThe lifecycle of South American Monsoon System (SAMS) plays an important role on the duration of the rainy season over large areas of South America, affecting the economy through impacts on agriculture, water resources and energy management. Numerical model prediction of SAMS onset, demise and related atmospheric features is an important tool to be used in management decisions in these sectors. This information is still missing in seasonal predictions, and the purpose of this study is to examine results of a climate simulation using the CPTEC/INPE AGCM to verify its ability in simulating the SAMS onset and demise as well as the associated atmospheric features. The SAMS lifecycle is identified using an index of the zonal humidity flux in the monsoon core. The model captured the atmospheric changes associated with the SAMS lifecycle, although showing differences in intensity and maximum locations of some variables, such as the magnitude of humidity flux, sea level pressure and omega, compared to reanalysis. During the onset, the model simulated the humidity flux direction changes, the eastward shifting of the South Atlantic Subtropical High and the northwesterly moisture flux east of tropical Andes. During the demise, the model simulated the easterly moisture flux directed toward the Amazon region and the reduction of northerly/northwesterly flow over northern South America, as well as the increase of Sea Level Pressure over the continent. Results obtained using a previous version of CPTEC/INPE AGCM are discussed, mainly the improvements, in the new version, of atmospheric variables and annual cycle of precipitation. The model was able to represent the main observed features of the SAMS lifecycle. The method can be useful to identify the onset and demise dates and could be applied to results of seasonal prediction prior to the rainy season, adding information to planning and management actions.
A climatological validation of urban air temperature and electricity demand simulated by a regional climate model coupled with an urban canopy model and a building energy model in an Asian megacity
Authors: Takane Yuya , Kikegawa Yukihiro , Hara Masayuki , Ihara Tomohiko , Ohashi Yukitaka , Adachi Sachiho A. , Kondo Hiroaki , Yamaguchi Kazuki , Kaneyasu Naoki 
Published: April 2017

ABSTRACTIn this study, we validated urban air temperature and electricity demand by a year‐round numerical simulation using a regional climate model coupled with an urban canopy model and a building energy model (RCM‐UCM+BEM) in the Asian megacity, Osaka, which is the largest metropolis in Japan after Tokyo. The control simulation (CTRL), which was based on the use of central air‐conditioning (AC) systems, reproduced the surface air temperatures observed in Osaka City in the summer cooling and interim seasons, but underestimated midnight to morning temperatures by over 2 °C in the winter heating season. In addition, the CTRL significantly overestimated the electricity demand in Osaka City in both the cooling and heating seasons, when the AC load was increased. These errors were likely due to the overestimation of AC use in the CTRL model because, in Japan, central AC systems are not used in business and residential areas, where individual AC units are mainly used. To prevent this overestimation, we introduced three new parameters to consider the use of partial AC systems in the model. The results of the new numerical experiment remarkably reduced the underestimation of temperature and the overestimation of electricity demand. This suggests that the RCM‐UCM+BEM modified by this study is effective for not only reproducing the current status of seasonal urban air temperature and electricity demand in Osaka, but also for projecting the future situation in other mega cities.
Modern diatom assemblages from Chilean tidal marshes and their application for quantifying deformation during past great earthquakes
Authors: Hocking Emma P. , Garrett Ed , Cisternas Marco 
Published: April 2017

ABSTRACTTidal marsh sediments from south‐central Chile provide evidence for multiple great earthquakes. Diatom transfer functions, statistical models of the relationship between species preserved in the sediment and elevation, provide quantitative estimates of coseismic vertical land‐level change associated with individual earthquakes. However, in south‐central Chile, our ability to quantify land‐level change is currently limited by a lack of understanding of the environmental variables controlling the distribution of diatoms, an essential prerequisite for converting variations in fossil diatom assemblages into quantitative estimates of past elevation changes. We present a new modern diatom dataset for the region and explore the implications of the scale of the dataset used in transfer function models on the reconstructions of land‐level change. Modern training sets containing samples from a regional scale are superior to sub‐regional and local‐scale training sets, providing closer estimates for known deformation during the great 1960 Chilean earthquake, a higher proportion of good modern analogues and uncertainty terms up to 42% smaller than previously published reconstructions. Copyright © 2017 The Authors. Journal of Quaternary Science Published by John Wiley & Sons Ltd.
Glacial landforms and their implications for glacier dynamics in Rijpfjorden and Duvefjorden, northern Nordaustlandet, Svalbard
Authors: Fransner O. , Noormets R. , Flink A. E. , Hogan K. A. , O'Regan M. , Jakobsson M. 
Published: April 2017

ABSTRACTObservations of subglacial landforms yielding the configuration and dynamics of former ice‐flows have for the first time been made in Rijpfjorden and Duvefjorden, Nordaustlandet, Svalbard, using sub‐bottom acoustic, swath‐bathymetric data and sediment cores. Five acoustic‐stratigraphic units were distinguished suggesting the presence of a complete glacial–postglacial succession in the central fjord basins. 14C ages from the sediments indicate that the inner Rijpfjorden and central Duvefjorden were deglaciated before ca. 10.6 cal ka BP and 11.0 cal ka BP, respectively. Maximum sediment thickness in Rijpfjorden and Duvefjorden is 26 m, resulting in sediment accumulation rates of ca. 66 cm ka−1. The landform record suggests that the ice streaming in both fjords was topographically controlled. The considerably deeper basin and higher elongation ratios of the crag‐and‐tails in Duvefjorden are linked to the faulted bedrock and possibly to somewhat larger ice stream and/or more focused ice‐flow compared to that in Rijpfjorden. De Geer moraines suggest slower retreat of a grounded ice margin from shallow areas of Rijpfjorden. In deeper areas of the fjords, the glaciers were probably floating, resulting in the lack of ice‐marginal transverse landforms. The ice margin retreat from these areas was probably relatively rapid and dominated by calving.
Immunostimulatory effect of aqueous extract of Coriandrum sativum L. seed on macrophages
Authors: Ishida Momoko , Nishi Kosuke , Kunihiro Nanami , Onda Hiroyuki , Nishimoto Sogo , Sugahara Takuya 
Published: April 2017

AbstractBACKGROUNDCoriandrum sativum L. seed is generally used as a spice and crude drug. Although many functions of the various components in C. sativum L. seed have been reported, the immunostimulatory effect of water‐soluble components in C. sativum L. seed has not been studied. In the present study, we focused on the immunostimulatory effect of C. sativum L. seed aqueous extract (CAE) on macrophages as a novel health function of C. sativum L. seed components.RESULTSCAE significantly enhanced the production of tumor necrosis factor (TNF)‐α and interleukin (IL)‐6 in both RAW264.7 cells and peritoneal macrophages by enhancing the expression levels of these cytokine genes. CAE also stimulated nitric oxide (NO) production and the phagocytosis activity in RAW264.7 cells. We suggest that the activity of CAE is a result of the upregulation of mitogen‐activated protein kinase and nuclear factor‐κB cascades via TLR4. In addition, IL‐6 production by peritoneal macrophages collected from CAE‐administered mice was significantly enhanced, suggesting that CAE could stimulate macrophage activity in vivo.CONCLUSIONThe findings of the present study suggest that CAE contains a novel water‐soluble component with an immunostimulatory effect on macrophages. CAE would contribute to activating host defense against pathogens by stimulating the innate immunity. © 2017 Society of Chemical Industry