bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spring-Assisted Cranioplasty for the Correction of Nonsyndromic Scaphocephaly: A Quantitative Analysis of 100 Consecutive Cases
Authors: Rodgers Will , Glass Graeme E. , Schievano Silvia , Borghi Alessandro , Rodriguez-Florez Naiara , Tahim Arpan , Angullia Freida , Breakey William , Knoops Paul , Tenhagen Maik , O’Hara Justine , Ponniah Allan , James Gregory , Dunaway David J. , Jeelani N. U. Owase 
Published: March 2017

Background:
Spring-assisted cranioplasty has been proposed as an alternative to total calvarial remodeling for sagittal craniosynostosis. Advantages include its minimally invasive nature, and reduced morbidity and hospital stay. Potential drawbacks include the need for a second procedure for removal and the lack of published long-term follow-up. The authors present a single-institution experience of 100 consecutive cases using a novel spring design.

Methods:
All patients treated at the authors’ institution between April of 2010 and September of 2014 were evaluated retrospectively. Patients with isolated nonsyndromic sagittal craniosynostosis were included. Data were collected for operative time, anesthetic time, hospital stay, transfusion requirement, and complications in addition to cephalic index preoperatively and at 1 day, 3 weeks, and 6 months postoperatively.

Results:
One hundred patients were included. Mean cephalic index was 68 preoperatively, 71 at day 1, and 72 at 3 weeks and 6 months postoperatively. Nine patients required transfusion. Two patients developed a cerebrospinal fluid leak requiring intervention. One patient required early removal of springs because of infection. One patient had a wound dehiscence over the spring and one patient sustained a venous infarct with hemiplegia. Five patients required further calvarial remodeling surgery.

Conclusions:
The authors’ modified spring design and protocol represents an effective strategy in the management of single-suture sagittal craniosynostosis with reduced total operative time and blood loss compared with alternative treatment strategies. In patients referred within the first 6 months of birth, this technique has become the authors’ procedure of choice. In a minority of cases, especially in the older age groups, further remodeling surgery is required.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Differentiation of Impaired From Preserved Hemodynamics in Patients With Fontan Circulation Using Real-time Phase-velocity Cardiovascular Magnetic Resonance
Authors: Körperich Hermann , Müller Katja , Barth Peter , Gieseke Jürgen , Haas Nikolaus , Schulze-Neick Ingram , Burchert Wolfgang , Kececioglu Deniz , Laser Kai T. 
Published: March 2017

Purpose:
Progressive impairment of hemodynamics in patients with Fontan circulation is common, multifactorial, and associated with decreased quality of life and increased morbidity. We sought to assess hemodynamic differences between patients with preserved (preserved Fontans) and those with impaired circulation (impaired Fontans) after pulmonary vasodilation using oxygen and under forced breathing conditions.

Materials and Methods:
Real-time phase-contrast cardiovascular magnetic resonance was performed using non–ECG triggered echo-planar imaging (temporal resolution=24 to 28 ms) in the ascending aorta (AAo) and superior vena cava (SVC)/inferior vena cava (IVC) on room air, after 100% oxygen inhalation (4 L/min; 10 min) and on forced breathing in 29 Fontan patients (17.2±7.3 y) and in 32 controls on room air (13.4±3.7 y). The simultaneously recorded patients’ respiratory cycle was divided into 4 segments (expiration, end-expiration, inspiration, and end-inspiration) to generate respiratory-dependent stroke volumes (SVs). The imaging data were matched with physiological data and analyzed with home-made software.

Results:
The mean SVi (AAo) was 46.1±11.1 mL/m2 in preserved Fontans versus 30.4±6.2 mL/m2 in impaired Fontans (P=0.002) and 51.1±6.9 mL/m2 in controls (P=0.107). The cutoff value for differentiation of Fontan groups was SVi (AAo, end-expiratory) of 32.1 mL/m2. After hyperoxygenation, the mean SVi (AAo) increased to 48.7±12.7 mL/m2 in preserved Fontans (P=0.045) but remained unchanged in impaired Fontans (31.1±5.8 mL/m2, P=0.665). Simultaneously, heart rates decreased from 75.2±15.9 to 70.8±16.4 bpm (preserved; P=0.000) but remained unchanged in impaired circulation (baseline: 84.1±9.8 bpm, P=0.612). Compared with physiological respiration, forced breathing increased the maximum respiratory-related cardiac index difference (ΔCImax) in preserved Fontans (SVC: 2.5-fold, P=0.000; and IVC: 1.8-fold, P=0.000) and to a lower extent in impaired Fontans (both veins, 1.5-fold; P(SVC)=0.011, P(IVC)=0.013). There was no impact on mean blood flow.

Conclusions:
Oxygen affected the pulmonary vascular system by vasodilation and increased SVi in preserved Fontans but had no effect on impaired Fontans. Forced breathing increased ΔCImax but did not change the mean blood flow by sole activation of the ventilatory pump. End-expiratory aortic SVi represents a valuable measure for classifying the severity of Fontan hemodynamics impairment.
Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation
Authors: Herigstad Mari , Faull Olivia , Hayen Anja , Evans Eleanor , Hardinge Maxine F. , Wiech Katja , Pattinson Kyle T. S. 
Published: March 2017

ABSTRACTBackgroundBreathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with airway pathophysiology (“over-perception”). Pulmonary rehabilitation has profound effects upon breathlessness, without influencing lung function. Learned associations can influence brain mechanisms of sensory perception. We therefore hypothesised that improvements in breathlessness with pulmonary rehabilitation may be explained by changing neural representations of learned associations, reducing “over-perception”.MethodsIn 31 patients with COPD, we tested how pulmonary rehabilitation altered the relationship between brain activity during learned associations with a word-cue task (using functional magnetic resonance imaging), clinical, and psychological measures of breathlessness.ResultsImprovements in breathlessness and breathlessness-anxiety correlated with reductions in word-cue related activity in the insula and anterior cingulate cortex (ACC) (breathlessness), and increased activations in attention regulation and motor networks (breathlessness-anxiety). Greater baseline (pre-rehabilitation) activity in the insula, ACC and prefrontal cortex correlated with the magnitude of improvement in breathlessness and breathlessness anxiety.ConclusionsPulmonary rehabilitation reduces the influence of learned associations upon neural processes that generate breathlessness. Patients with stronger word-cue related activity at baseline benefitted more from pulmonary rehabilitation. These findings highlight the importance of targeting learned associations within treatments for COPD, demonstrating how neuroimaging may contribute to patient stratification and more successful personalised therapy.
Transcripts’ evolutionary history and structural dynamics give mechanistic insights into the functional diversity of the JNK family
Authors: Ait-hamlat Adel , Zea Diego Javier , Labeeuw Antoine , Polit Lélia , Richard Hugues , Laine Elodie 
Published: March 2017

AbstractAlternative splicing and alternative initiation/termination transcription sites, have the potential to greatly expand the proteome in eukaryotes by producing several transcript isoforms from the same gene. Although these mechanisms are well described at the genomic level, little is known about their contribution to protein evolution and their impact at the protein structure level. Here, we address both issues by reconstructing the evolutionary history of transcripts and by modeling the tertiary structures of the corresponding protein isoforms. We reconstruct phylogenetic forests relating 60 transcripts from the c-Jun N-terminal kinase (JNK) family observed in 7 species. We identify two alternative splicing events of ancient origin and show that they induce subtle changes on the protein’s structural dynamics. We highlight a previously uncharacterized transcript whose predicted structure seems stable in solution. We further demonstrate that orphan transcripts, for which no phylogeny could be reconstructed, display peculiar sequence and structural properties. Our approach is implemented in PhyloSofS (Phylogenies of Splicing Isoforms Structures), a fully automated computational tool freely available athttps://github.com/PhyloSofS-Team/PhyloSofS.
The Rice XA21 Ectodomain Fused to the Arabidopsis EFR Cytoplasmic Domain Confers Resistance toXanthomonas oryzaepv.oryzae
Authors: Thomas Nicholas , Oksenberg Nir , Liu Furong , Caddell Daniel , Nalyvayko Alina , Nguyen Yen , Schwessinger Benjamin , Ronald Pamela 
Published: March 2017

SummaryRice (Oryza sativa) plants expressing the XA21 cell surface receptor kinase are resistant toXanthomonas oryzaepv.oryzae(Xoo) infection. We previously demonstrated that expressing a chimeric protein containing the EFR (ELONGATIONFACTOR TuRECEPTOR) ectodomain and the XA21 endodomain (EFR:XA21) in rice does not confer robust resistance toXoo.To test if the XA21 ectodomain is required forXooresistance, we produced transgenic rice lines expressing a chimeric protein consisting of the XA21 ectodomain and EFR endodomain (XA21:EFR) and inoculated these lines withXoo. We also tested if the XA21:EFR rice plants respond to a synthetic sulfated 21 amino acid derivative (RaxX21-sY) derived from the activator of XA21-mediated immunity, RaxX.We found that five independently transformed XA21:EFR rice lines displayed resistance toXooas measured by lesion length analysis, and showed that five lines express markers of the XA21 defense response (generation of reactive oxygen species and defense response gene expression) after treatment with RaxX21-sY.Our results indicate that expression of the XA21:EFR chimeric receptor in rice confers resistance toXoo. These results suggest that the endodomain of the EFR and XA21 immune receptors are interchangeable and the XA21 ectodomain is the key determinant conferring robust resistance toXoo.
The impact of digital library resources usage on engineering research productivity: an empirical evidences from Pakistan
Authors: Khan Amjid , Ahmed Shamshad , Khan Asad , Khan Ghalib 
Published: March 2017

PurposeThe role of digital library resources (DLRs) in accelerating academic and research productivity has been acknowledged worldwide. The purpose of this study is to empirically explore the use of DLRs as a predictor of satisfaction and research productivity in the context of Pakistan to examine its impact on engineering research productivity.Design/methodology/approachGiven the research objectives, the most suitable methodology for this study is survey. The tool used for gathering the research data on the frequency of usage, purpose, satisfaction level and impact of DLRs usage on research productivity was questionnaires.FindingsThe findings of this study showed that the frequency of use of DLRs and purposes of DLRs significantly contributed to the research students’ satisfaction and research productivity. In addition, a significant relationship was found between the predictors (DLRs purposes, DLRs frequency) and outcome variables (users’ satisfaction and research productivity). Thus, all five hypotheses are supported. The findings of this study further suggested the provision of information sources by university libraries to support research efforts and make a scientific knowledge-based society in the country. The findings are also significant for Higher Education Commission (HEC) authorities, university library administrators, Library and Information Science professionals/information providers to develop e-resources and formulate effective usage policies through which they could make effective use of DLRs.Originality/valueThe rationale of the present study is to fill the gap by empirically investigating the association of users’ satisfaction and research productivity with two dimensions of DLRs, namely, DLRs usage frequency and purposes of DLRs usage.
Impact of disaster on access to records of National Archives of South East, Nigeria
Authors: Onyeneke Cajetan Okechukwu 
Published: March 2017

Purpose
The purpose of this study is to investigate the incidence of disaster and how it affects access to records of the National Archives of South East, Nigeria. However, the specific objectives are to: identify the types of disasters that occur in the archives of South East, Nigeria; ascertain the frequency with which the disasters occur in the archives; determine the relationship between disaster and access to records of the archives; find out the disaster prevention measures adopted by the archives; find out the disaster response and recovery plans available in the archives; and make recommendations for effective disaster prevention and control measures for the archives.

Design/methodology/approach
The research design adopted for this study is the survey method. Individuals constituted the respondents of the study. This design assisted in gathering accurate data of the given issues and also guided in discussing the findings of the study. The researcher adopted one technique in data collection. Questionnaire was used for primary data collection. Questionnaire was used to collect data from the staff of the National Archives.

Findings
The findings show that the most prevalent disaster experienced in the archives is power failure. There are occurrences of other man-made disasters in the archives such as stealing, vandalism, fire outbreak and water leakages. The only natural disaster they acknowledged that occurs in the archives is lightening strike. The effect of this disaster was found to be enormous as attested to by 90.9 and 75 per cent respondents in Enugu and Owerri, respectively. The respondents do not agree that natural phenomena such as earthquake/tsunami, volcanic eruption and landslides do constitute threat to records of the archives.

Originality/value
The events of disaster, in whatever shape or frequency, impede access to records of the National Archives of South East, Nigeria. Most of the disasters that affect the archives are man-made, but with the recent happenings around the globe – the global climate change – it becomes imperative to focus attention on eventual occurrence of natural disasters in the archives. In prevention, response and recovery plans, it is important that consideration is given to all areas likely to be affected by the disaster.
With your headphones on: go global or stay local?
Authors: Wójcik Piotr , Wasowska Aleksandra , Oblój Krzysztof , Ciszewska-Mlinaric Mariola 
Published: March 2017

Subject area
International Business, Entrepreneurship.

Study level/applicability
This case has been used previously in an international business strategy module on MA courses at Kozminski University, Poland.

Case overview
The case details Audioteka’s (a Polish audiobook company) history between 2007 and 2013, from the perspective of Marcin, one of the co-founders. The company was founded in 2008 by Marcin Beme and Blazej Kukla and internationalized soon after. Marcin was an experienced entrepreneur, while Blazej was a sound engineer. Both sought to combine their complementary skills and experience to start a business aimed at selling audio recordings. The case is divided into Parts (A) and (B) and is designed to teach international entrepreneurship, lying at the intersection of international business and entrepreneurship. Part (A) is set in 2011 and tracks the company’s evolution from the conception of an idea to establishing a start-up and developing a product. Part (B) is set in 2013 and covers early foreign expansion between 2011 and 2013. The case is focused on the challenges that Marcin faces when developing Audioteka and expanding abroad. It allows students to understand the decision-making logic of an international new venture (INV), choices made and execution while internationalizing. Students will be able to explore how a company adapts its product; how it enters foreign markets; how it overcomes the liabilities of foreignness, smallness, newness and outsidership through establishing partnerships with big companies (telecoms, automakers); and how it appreciates the risks involved in this process.

Expected learning outcomes
This case is the basis for a class discussion rather than for illustrating either effective or ineffective handling of a managerial situation. From this case, MA students will learn how an entrepreneurial firm makes strategic decisions and becomes international. The first learning outcome is to evaluate the concepts of liability of origin, foreignness, outsidership, smallness and newness, and to explore ways of overcoming them. Second, the expected learning outcome is to assess differences between the Uppsala model of internationalization and born-global/INV phenomenon. Third, students, by examining particular foreign market-entry modes, are expected to evaluate their advantages and disadvantages. Finally, students are expected to understand the concept of “effectuation” and apply it to the decision-making process in early internationalization.

Subject code
CSS 5: International Business.
Predicting sustainability assessment at early facilities design phase
Authors: Zileska Pancovska Valentina , Petrusheva Silvana , Petrovski Aleksandar 
Published: March 2017

PurposeIntegrating the aspects of sustainability into facilities design has become a designers’ challenge, and the early design phase is seen as the most important in implementing sustainability into facilities design. Therefore, this paper aims to analyze the factors that influence sustainability assessment of preliminary design of facilities and predicts sustainability assessment depending on those factors.

Design/methodology/approachData were collected by survey questionnaire distributed to project managers using a six-point Likert scale. Obtained data were modeled with general regression neural network (GRNN) using DTREG software. In total, 27 factors were chosen for determining the most accurate predictive model, and their importance was computed.

FindingsThe six most important factors for sustainability assessment of facilities design are: work experience, work on several outline design proposals, resolving issues between stakeholders, prioritization of participants in the design phase, procurement management and defining projects’ program and goals. The predictive model that was used for prediction of the sustainability assessment was shown to be highly accurate, with MAPE (mean absolute percentage error) amounting to 2.58 per cent.

Practical implicationsUsing the same approach, assessment of every other factor for the preliminary design can be predicted and the factors that are most influential to its sustainability can be obtained.

Originality/valueThe paper supports the sustainability improvement of the preliminary design of future facilities’ projects, as well as support during the decision-making process.
Albania vs Norway – FM at two university hospitals
Authors: Boge Knut , Aliaj Anjola 
Published: March 2017

PurposeGiven the premise of de facto universal standards for FM, this paper aims to investigate development of facilities management (FM) at an Albanian and a Norwegian university hospital through examination of two hypotheses: the university hospital has recognised FM and established a designated FM organisation (H1) and the university hospital provides adequate food and catering services at ward kitchens and buffets (H2).

Design/methodology/approachThis is an exploratory and descriptive comparative case study based on a diverse cases’ designs.

FindingsThere is limited and strong support for H1 at the Albanian and Norwegian university hospitals, respectively. Both the Albanian and the Norwegian university hospitals rely on in-house production of facilities services, but the Albanian university hospital has outsourced food and catering services. FM and provision of facilities services are deeply integrated within the Norwegian university hospital’s core activities. There is also limited and strong support for H2 at the Albanian and Norwegian university hospitals, respectively. Hence, the Albanian Ministry of Health and the Albanian university hospital’s top management have a comprehensive, but not impossible, task, if the aim is to catch up with the Norwegian university hospital concerning FM.

Research limitations/implicationsThis is an exploratory and descriptive comparative case study. Large N studies should be carried out both in Albania and Norway and preferably also in other countries to corroborate and develop the findings.

Originality/valueThis is the first comparative study of FM at an Albanian and a Norwegian university hospital.
Effective social media marketing strategy: Facebook as an opportunity for universities
Authors: Assimakopoulos Costas , Antoniadis Ioannis , Kayas Oliver G. , Dvizac Dragana 
Published: March 2017

Purpose
The purpose of this paper is to investigate the usage of university Facebook (FB) groups and sites by undergraduate students seeking information about their departments and the ways these pages could be used to acquire students. The factors that can intensify the FB group activities of a university are examined as well as how FB can be used as a marketing tool to improve marketing campaigns.

Design/methodology/approach
The study investigates and compares two universities: the University of Novi Sad of the Republic of Serbia and the Technological Educational Institute of Western Macedonia, Greece. A structured questionnaire was used with samples of 343 and 300 students gathered in this survey.

Findings
An enhanced technology acceptance model oriented toward FB is presented and it is the conceptual background of the paper. Student demographics and behavioral characteristics of the FB group they enrolled on were determined. Common behavioral patterns of the usage tension of the FB group are also identified. Additionally, five factors were determined that can be used by university marketers to intensify engagement with the FB group.

Research limitations/implications
Larger samples should be used for future research.

Originality/value
The paper proposes a marketing strategy a higher education institution should follow to more effectively use social networking sites as a marketing tool.
Impact of electronic-wallet system on farmer’s welfare in Oyo State, Nigeria
Authors: Ifeyinwa Umeokeke Nneji , Olusegun Okoruwa Victor , Adenike Adeyemo Temitayo 
Published: March 2017

Purpose
The purpose of this paper is to examine the impact of e-wallet on farmer’s welfare in Nigeria.

Design/methodology/approach
Primary data were used to collect information on 81 users and 123 non-users of e-wallet system. Foster, Greer and Thorbecke (FGT) analysis was used to profile farmer’s poverty status, while propensity score matching (PSM) was used to assess the impact of e-wallet on welfare using per capita expenditure as its proxy.

Findings
The FGT analysis shows that poverty incidence, depth, and severity were found to be higher among non-users of e-wallet than its users. The PSM analysis showed that e-wallet had a positive impact on welfare; Rosenbaum sensitivity analysis revealed that the findings are sensitive to hidden bias due to unobserved characteristics.

Research limitations/implications
The relevance of matching method depends on data availability for the specific policy problem. Hence, the study is limited to the use of the PSM because of the limitation of household data availability to only a sample of farmers in Oyo State.

Originality/value
This paper examines the impact of the new system of input distribution (e-wallet) on farmer’s welfare.