bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Eicosapentaenoic and Docosahexaenoic Acids Added to Statin Therapy on Coronary Artery Plaque in Patients With Coronary Artery Disease: A Randomized Clinical Trial
Authors: Alfaddagh Abdulhamied , Elajami Tarec K. , Ashfaque Hasan , Saleh Mohamad , Bistrian Bruce R. , Welty Francine K. 
Published: December 2017

Background
Although statins reduce cardiovascular events, residual risk remains. Therefore, additional modalities are needed to reduce risk. We evaluated the effect of eicosapentaenoic acid and docosahexaenoic acid in pharmacologic doses added to statin treatment on coronary artery plaque volume.

Methods and Results

A total of 285 subjects with stable coronary artery disease on statins were randomized to omega‐3 ethyl‐ester (1.86 g of eicosapentaenoic acid and 1.5 g of docosahexaenoic acid daily) or no omega‐3 (control) for 30 months. Coronary plaque volume was assessed by coronary computed tomographic angiography. Mean (
SD
) age was 63.0 (7.7) years; mean low‐density lipoprotein cholesterol ≤80 mg/dL. In the intention‐to‐treat analysis, our primary endpoint, noncalcified plaque volume, was not different between groups (
P
=0.14) but approached significance in the per protocol analysis (
P
=0.07). When stratified by age in the intention‐to‐treat analysis, younger omega‐3 subjects had significantly less progression of the primary endpoint, noncalcified plaque (
P
=0.013), and fibrous, calcified and total plaque. In plaque subtype analysis, controls had significant progression of fibrous plaque compared to no change in the omega‐3 ethyl‐ester group (median % change [interquartile range], 5.0% [−5.7, 20.0] versus −0.1% [−12.3, 14.5], respectively;
P
=0.018). Among those on low‐intensity statins, omega‐3 ethyl‐ester subjects had attenuation of fibrous plaque progression compared to controls (median % change [interquartile range], 0.3% [−12.8, 9.0] versus 4.8% [−5.1, 19.0], respectively;
P
=0.032). In contrast, those on high‐intensity statins had no difference in plaque change in either treatment arm.

Conclusions
High‐dose eicosapentaenoic acid and docosahexaenoic acid provided additional benefit to statins in preventing progression of fibrous coronary plaque in subjects adherent to therapy with well‐controlled low‐density lipoprotein cholesterol levels. The benefit on low‐intensity statin, but not high‐intensity statin, suggests that statin intensity affects plaque volume.

Clinical Trial Registration

URL
:
http://www.ClinicalTrials.gov
. Unique identifier:
NCT
01624727.
Establishing Measurement Equivalence Across Computer- and Paper-Based Tests of Spatial Cognition
Authors: Bailey Shannon K. T. , Neigel Alexis R. , Dhanani Lindsay Y. , Sims Valerie K. 
Published: December 2017

Objective The purpose of the present research is to establish measurement equivalence and test differences in reliability between computerized and pencil-and-paper-based tests of spatial cognition. Background Researchers have increasingly adopted computerized test formats, but few attempt to establish equivalence for computer-based and paper-based tests. The mixed results in the literature on the test mode effect, which occurs when performance differs as a function of test medium, highlight the need to test for, instead of assume, measurement equivalence. One domain that has been increasingly computerized and is thus in need of tests of measurement equivalence across test mode is spatial cognition. Method In the present study, 244 undergraduate students completed two measures of spatial ability (i.e., spatial visualization and cross-sectioning) in either computer- or paper-and-pencil-based format. Results Measurement equivalence was not supported across computer-based and paper-based formats for either spatial test. The results also indicated that test administration type affected the types of errors made on the spatial visualization task, which further highlights the conceptual differences between test mediums. Paper-based tests also demonstrated increased reliability when compared with computerized versions of the tests. Conclusion The results of the measurement equivalence tests caution against treating computer- and paper-based versions of spatial measures as equivalent. We encourage subsequent work to demonstrate test mode equivalence prior to the utilization of spatial measures because current evidence suggests they may not reliably capture the same construct. Application The assessment of test type differences may influence the medium in which spatial cognition tests are administered.
The effectiveness of hydrokinesiotherapy on postural balance of hemiplegic patients after stroke: a systematic review and meta-analysis
Authors: Iatridou Georgia , Pelidou Henrietta-Syngliti , Varvarousis Dimitrios , Stergiou Alexandra , Beris Alexander , Givissis Panagiotis , Ploumis Avraam 
Published: December 2017

Objective: To summarize evidence on the effects of hydrokinesiotherapy (HT) on postural balance in hemiplegic patients after stroke and compare them with conventional land therapy. Data sources: A literature search until October 2017 was conducted on CINAHL, PubMed, Cochrane EBM Reviews, Cochrane Clinical Trials, DARE, MEDLINE, Physiotherapy Evidence Database (PEDro), PsycInfo and Rehabilitation and Sports Medicine Source. Review methods: Only randomized controlled trials with pre-intervention and post-intervention assessment on postural control have been included. Assessment of the quality (by Downs and Black quality assessment tool) of the included studies was performed by two reviewers, and a meta-analysis was undertaken. Results: A total of 11 trials on postural control with 305 stroke patients were included. The majority of studies showed a beneficial effect of HT in postural control of the patients. The meta-analysis showed statistically significant improvement ( P < 0.05) in Berg Balance Scale (BBS), mediolateral (ML) and anteroposterior (AP) sway velocity of center of pressure with eyes closed (EC) in both groups, but the mean differences in BBS (3.85 points), ML sway velocity of center of pressure (1.38 points) and AP sway velocity of center of pressure (1.64 points) were statistically improved ( P < 0.05) in HT over land therapy program. Conclusion: HT is superior to land therapy program regarding postural balance in terms of BBS, ML and AP sway velocity of center of pressure.
Hip Distraction Without a Perineal Post: A Prospective Study of 1000 Hip Arthroscopy Cases
Authors: Mei-Dan Omer , Kraeutler Matthew J. , Garabekyan Tigran , Goodrich Jesse A. , Young David A. 
Published: December 2017

Background: Hip arthroscopy has traditionally been performed with a perineal post, resulting in various groin-related complications, including pudendal nerve neurapraxias, vaginal tears, and scrotal necrosis. Purpose: To assess the safety of a technique for hip distraction without the use of a perineal post. Study Design: Case series; Level of evidence, 4. Methods: We prospectively analyzed a consecutive cohort of 1000 hips presenting to a dedicated hip preservation clinic; all patients had hip pain and were subsequently treated with hip arthroscopy. Demographic variables, hip pathology, and lateral center edge angle were recorded for each case. In the operating room, the patient’s feet were placed in traction boots in a specifically designed distraction setup, and the operative table was placed in varying degrees of Trendelenburg. With this technique, enough resistance is created by gravity and friction between the patient’s body and the bed to allow for successful hip distraction without the need for a perineal post. In a subset of 309 hips (n = 281 patients), the degrees of Trendelenburg as well as the distraction force were analyzed. Results: The mean ± SD Trendelenburg angle used among the subset of 309 hips was 11° ± 2°. The mean initial distraction force necessary was 90 ± 28 lb, which decreased to 65 ± 24 lb by 30 minutes after traction initiation ( P < .0001). The most important variables in determining initial force for this cohort of patients were, in order of magnitude, sex ( P < .0001), weight ( P < .0001), and lateral center edge angle ( P < .01). No groin-related complications occurred among the entire cohort of patients, including soft tissue or nerve-related complications. The rate of deep venous thrombosis was 2 in 1000. Conclusion: The use of the Trendelenburg position and a specially designed distraction setup during hip arthroscopy allows for safe hip distraction without a perineal post, thereby eliminating groin-related soft tissue and nerve complications. Certain patient variables can be used to estimate the required distraction force and inclination angle with this method.
The Relationship Between Hospital Construction and High-Risk Infant Auditory Function at NICU Discharge: A Retrospective Descriptive Cohort Study
Authors: Willis Valerie 
Published: December 2017

Purpose: To describe the difference in auditory function at neonatal intensive care unit (NICU) discharge between high-risk infant cases exposed to hospital construction during NICU stay and those not exposed. Background: Noise produced by routine NICU caregiving exceeds recommended intensity. As California hospitals undergo construction to meet seismic safety regulations, vulnerable neonates are potentially exposed to even higher levels of noise. Ramifications are unknown. Methods: Retrospective data-based descriptive cohort design was used to compare high-risk infant auditory function at NICU discharge between hospital construction exposed and unexposed groups. Sample size: N = 540 infant cases (243 construction exposed and 297 unexposed controls). Inclusion criteria: Infant cases born and discharged from the study site NICU in the year 2010 (unexposed) and year 2015 (exposed) and received a newborn hearing screening by automated auditory brainstem evoked response (ABER) prior to discharge with results reported. Infant cases excluded: hearing screen results by ABER unavailable, potentially confounding characteristics (congenital infection, major anomalies including cleft lip and/or palate), and transferred into or out of the study site. Instrumentation: ABER. Analysis: descriptive statistics (SPSS Version 24.0), hypothesis testing, correlation, and logistic regression. Results: The difference in auditory function at NICU discharge between high-risk infant cases exposed to hospital construction noise and those unexposed was statistically insignificant, χ2 = 1.666, df = 4, p = .1968, 95% confidence interval [−0.635, 2.570]. Conclusions: More research is needed to better understand whether hospital construction exposure during NICU admission negatively affects high-risk infant auditory function. Findings may catalyze theory development, future research, and child health policy.
Can Biologic Augmentation Improve Clinical Outcomes Following Microfracture for Symptomatic Cartilage Defects of the Knee? A Systematic Review
Authors: Arshi Armin , Fabricant Peter D. , Go Derek E. , Williams Riley J. , McAllister David R. , Jones Kristofer J. 
Published: December 2017

Objective To perform a systematic review of clinical outcomes following microfracture augmented with biological adjuvants (MFX+) compared with microfracture (MFX) alone. Design The MEDLINE, Scopus, and Cochrane databases were searched for clinical studies on MFX+ for chondral defects of the knee. Study characteristics and clinical outcome score data were collected. Subjective synthesis was performed using data from randomized controlled studies to determine effect size of MFX+ procedures performed with either injectable or scaffold-based augmentation compared with MFX alone. Results A total of 18 articles reporting on 625 patients (491 MFX+, 134 MFX) were identified. Six studies were level II evidence and 1 study was level I evidence. Mean patient age range was 26 to 51 years, and mean follow-up ranged from 2 to 5 years. All studies demonstrated significant improvement in reported clinical outcome scores at follow-up after MFX+ therapy, and 87% of patients reported satisfaction with treatment. The most commonly reported treatment complication was postoperative stiffness (3.9% of patients). Subjective synthesis on randomized controlled trials demonstrated that 2/2 injectable MFX+ interventions had significantly greater improvements in International Knee Documentation Committee Subjective Knee Form (IKDC; P = 0.004) and Knee injury and Osteoarthritis Outcome Score (KOOS; P = 0.012) scores compared with MFX alone, while 2/2 trials on scaffolding MFX+ adjuvants showed comparable postoperative improvements. Conclusions MFX+ biological adjuvants are safe supplements to marrow stimulation for treating cartilage defects in the adult knee. Early literature is heterogenous and extremely limited in quality. Individual trials report both equivalent and superior clinical outcomes compared with MFX alone, making definitive conclusions on the efficacy of MFX+ difficult without higher quality evidence.
Health-related quality of life and risk of composite coronary heart disease and cerebrovascular events in the Moli-sani study cohort
Authors: Bonaccio Marialaura , Di Castelnuovo Augusto , Costanzo Simona , Persichillo Mariarosaria , De Curtis Amalia , Cerletti Chiara , Donati Maria Benedetta , de Gaetano Giovanni , Iacoviello Licia 
Published: December 2017

Background To assess the association between health-related quality of life (HRQL) and a composite outcome including incident coronary heart disease (CHD) and cerebrovascular events in a large general population-based cohort. Design Prospective analysis on 17,102 men and women (mean age 53 ± 11) free from cardiovascular disease at time of enrolment in the Moli-sani cohort (2005–2010). Methods HRQL was assessed by the 36-Item Short Form Health Survey. Hazard ratios with 95% confidence intervals (95% CIs) were calculated using multivariable Cox-proportional hazard models. Results At the end of follow-up (median 4.2 years), 237 new events occurred (coronary heart disease n = 197, cerebrovascular disease n = 42). In a multivariable model adjusted for socioeconomic factors, chronic disease and health-related behaviours, both mental and physical HRQL were inversely associated with the risk of the composite outcome (hazard ratio = 0.57; 0.39–0.84 and hazard ratio = 0.62; 0.40–0.94, respectively; highest vs. lowest quartile). Further adjustment for C-reactive protein marginally modified the association with physical HRQL (hazard ratio = 0.67; 0.43–1.02). Similar findings were obtained when only CHD events were analysed (hazard ratio = 0.63; 0.41–0.96 for highest versus lowest mental HRQL) although results with physical HRQL were no longer significant (hazard ratio = 0.65; 0.40–1.04 for highest versus lowest quartile). Associations with incident cerebrovascular disease showed a trend toward protection (hazard ratio = 0.50; 0.22–1.17 and hazard ratio = 0.51; 0.22–1.23 for highest versus lowest tertile of mental and physical HRQL, respectively). Conclusions HRQL is an independent predictor of composite CHD/cerebrovascular outcomes in an adult population. The magnitude of the association was not affected either by socioeconomic factors, health conditions or health-related behaviours. Improvement of quality of life may be a major factor in targeting appropriate prevention strategies for cardiovascular health.
‘The Grocers Honour’: or, Taking the City Seriously in <i>The Knight of the Burning Pestle</i>
Authors: Hill Tracey 
Published: December 2017

The Knight of the Burning Pestle famously flopped when first performed c. 1607. Critical debate over its so-called ‘privy mark of irony’ has subsequently oscillated between those who argue that the play did not satirize the London citizenry trenchantly enough, and those who prefer the interpretation that the ‘irony’ was only too apparent, and that this alienated the audience. Few have fully interrogated the play’s complex engagement with the early Jacobean citizen class and the City of London’s livery companies. This paper argues that The Knight’s presentation of citizens takes place in the context both of a theatre much more involved in civic structures, and of a city more imbued with performance, than is usually presumed.
Genetic Identification of Separase Regulators inCaenorhabditis elegans
Authors: Melesse Michael , Sloan Dillon E , Benthal Joseph T , Caylor Quincey , Gosine Krishen , Bai Xiaofei , Bembenek Joshua N 
Published: December 2017

AbstractSeparase is a highly conserved protease required for chromosome segregation. Although observations that separase also regulates membrane trafficking events have been made, it is still not clear how separase achieves this function. Here, we present an extensive ENU mutagenesis suppressor screen aimed at identifying suppressors of sep-1(e2406), a temperature-sensitive maternal effect embryonic lethal separase mutant that primarily attenuates membrane trafficking rather than chromosome segregation. We screened nearly a million haploid genomes and isolated 68 suppressed lines. We identified 14 independent intragenic sep-1(e2406) suppressed lines. These intragenic alleles map to seven SEP-1 residues within the N-terminus, compensating for the original mutation within the poorly conserved N-terminal domain. Interestingly, 47 of the suppressed lines have novel mutations throughout the entire coding region of the pph-5 phosphatase, indicating that this is an important regulator of separase. We also found that a mutation near the MEEVD motif of HSP-90, which binds and activates PPH-5, also rescues sep-1(e2406) mutants. Finally, we identified six potentially novel suppressor lines that fall into five complementation groups. These new alleles provide the opportunity to more exhaustively investigate the regulation and function of separase.
Non-Destructive impact method for quality assessment of horticultural products
Authors: Felföldi J. , Kertész I. , Nagy D. , Zsom-Muha V. 
Published: December 2017

In the case of organic production the quality assessment of the fruits and vegetables is especially important. Monitoring of the maturation and ripening process, early detection of diseases, decision about harvest date and postharvest treatment need reliable, objective and – preferably – non-destructive quality testing methods. Dynamic hardness or stiffness measurement methods (resonance, impact, wave propagation) offer very useful tools in this field, but with strong limitations in applicability area and/or physical interpretation of the measured parameters. Our objective was to develop method and appropriate portable instrumentation to measure surface hardness – as quality measure – with a nondestructive method.
The computer controlled instrument has an electromagnetically excited impactor fitted with a piezoelectric acceleration sensor, a signal conditioner and A/D converter. To ensure the uniform contact behavior (contact area) between the impactor and the tested produce of wide range of shape, spherical head was applied. Conclusively, Hertz contact theory is to be applied for evaluation of the impact signal. Instead of using empirical “hardness index” – as in the case of several existing instruments – our objective was the physical interpretation of the contact phenomena. The measured acceleration signal was mathematically processed to calculate real physical parameters (force, speed, deformation), and to characterize the process similarly to the widely used texture analyzers, penetrometers. A new hardness parameter – “dynamic elastic modulus” – was introduced. According to the methodological investigations, the measurement was found to be perfectly non-destructive for a wide range of products. Conclusively, the developed method offers a useful tool for quality evaluation of organic horticultural products.
Analysis of Factors Affect to Organizational Performance In Using Accounting Information Systems Through Users Satisfaction and Integration Information Systems
Authors: Arisman Anton , Fuadah Lukluk 
Published: December 2017

The aim of this research is to investigate the factors affecting organizational performance in using accounting information system through users satisfaction and integration information systems. The research respondents were 447 companies that listed in Indonesian Stock Exchange. The data are gathered through consensus method and in total there are 176 responses with complete data. Structural Equation Model (SEM) is used in analyzing the data and system theory is utilized in this research. The result shows that knowledge management systems and management control system have significant influence on users satisfaction and integration information systems. Integration information system and users satisfaction has positive significant on organizational performance.
The Use of the OMERACT Ultrasound Tenosynovitis Scoring System in Multicenter Clinical Trials
Authors: Ammitzbøll-Danielsen Mads , Østergaard Mikkel , Naredo Esperanza , Iagnocco Annamaria , Möller Ingrid , D’Agostino Maria-Antonietta , Gandjbakhch Frédérique , Terslev Lene 
Published: December 2017

Objective.To test the sensitivity to change of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) ultrasound (US) scoring system for tenosynovitis when applied in a multicenter design.Methods.RA patients with US-verified tenosynovitis were recruited when scheduled for treatment intensification. Tenosynovitis was assessed at baseline, and 3 and 6 months followup, using the semiquantitative OMERACT scoring system.Results.Expressed in median (25th; 75th percentiles), the overall greyscale and Doppler score decreased significantly from baseline at 4 (2; 7) and 3 (2; 6), to 6 months at 2 (0; 3) and 0 (0; 1, p < 0.01), respectively, and showed high responsiveness (standardized response mean ≥ 0.8).Conclusion.The OMERACT US scoring system for tenosynovitis showed high responsiveness, supporting its use for diagnosing and monitoring tenosynovitis in multicenter trials.
Styles de management, climat social et climat éthique : une approche contextuelle
Authors: Barel Yvan , Dumas Marc , Frémeaux Sandrine 
Published: December 2017

Soumis à des exigences économiques plus fortes, les managers peuvent s’interroger sur le choix du style de management – directif, par l’exemple, coopératif, participatif, mentor, mobilisateur – et sur son incidence éventuelle sur les climats social et éthique. Fondée sur l’étude d’une organisation semi-publique de 598 salariés donnant lieu à une enquête par questionnaire (322 retours exploitables), suivie d’une investigation qualitative (auprès de 88 cadres intermédiaires), cette étude a testé les liens entre les styles de management et le climat social ainsi que les liens entre les styles de management et le climat éthique. Elle révèle que le style coopératif peut avoir le lien positif le plus élevé avec le climat éthique bienveillant et que, dans un contexte marqué par un déficit d’orientation du top management, tous les styles de management, y compris les styles directif et par l’exemple, peuvent avoir un effet favorable sur les climats.