bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Repeated Visits to a Pediatric Emergency Department Crisis Intervention Program
Authors: Cloutier P. , Thibedeau N. , Barrowman N. , Gray C. , Kennedy A. , Leon S.L. , Polihronis C. , Cappelli M. 
Published: August 2016

AbstractObjectivesDespite documented increases in emergency department (ED) mental health (MH) presentations, there are inconsistent findings on the characteristics of patients with repeat presentations to pediatric EDs (PEDs) for MH concerns. Our study sought to explore the characteristics of MH patients with repeat PED visits and determine predictors of return visits, of earlier repeat visits, and of more frequent repeat visits.MethodsWe examined data collected prospectively in a clinical database looking at MH presentations to a crisis intervention program housed within a PED from October 2006 to December 2011. Predictive models based on demographic and clinical variables were constructed using logistic, Cox, and negative binomial regression.ResultsA total of 4,080 presentations to the PED were made by the 2,900 children and youth. Repeat visits accounted for almost half (45.8%) of all presentations. Multivariable analysis identified five variables that independently predicted greater odds of having repeat presentations, greater risk of earlier repeat presentations, and greater risk of frequent repeat presentations. The five variables were: female, living in the metropolitan community close to the PED, being in the care of child protective services, taking psychotropic medications, and presenting with an actionable need in the area of mood disturbances.ConclusionsRepeat visits account for a large portion of all MH presentations to the PED. Furthermore, several patient characteristics are significant predictors of repeat PED use and of repeating use sooner and more frequently. Further research is needed to examine interventions targeting this patient group to ensure appropriate MH patient management.
Device and Medication Preferences of Canadian Physicians for Emergent Endotracheal Intubation in Critically Ill Patients
Authors: Green Robert S. , Fergusson Dean A. , Turgeon Alexis F. , McIntyre Lauralyn A. , Kovacs George J. , Griesdale Donald E. , Zarychanski Ryan , Butler Michael B. , Kureshi Nelofar , Erdogan Mete 
Published: August 2016

AbstractObjectivesVarious medications and devices are available for facilitation of emergent endotracheal intubations (EETIs). The objective of this study was to survey which medications and devices are being utilized for intubation by Canadian physicians.MethodsA clinical scenario-based survey was developed to determine which medications physicians would administer to facilitate EETI, their first choice of intubation device, and backup strategy should their first choice fail. The survey was distributed to Canadian emergency medicine (EM) and intensive care unit (ICU) physicians using web-based and postal methods. Physicians were asked questions based on three scenarios (trauma; pneumonia; heart failure) and responded using a 5-point scale ranging from “always” to “never” to capture usual practice.ResultsThe survey response rate was 50.2% (882/1,758). Most physicians indicated a Macintosh blade with direct laryngoscopy would “always/often” be their first choice of intubation device in the three scenarios (mean 85% [79%-89%]) followed by video laryngoscopy (mean 37% [30%-49%]). The most common backup device chosen was an extraglottic device (mean 59% [56%-60%]). The medications most physicians would “always/often” administer were fentanyl (mean 45% [42%-51%]) and etomidate (mean 38% [25%-50%]). EM physicians were more likely than ICU physicians to paralyze patients for EETI (adjusted odds ratio 3.40; 95% CI 2.90-4.00).ConclusionsMost EM and ICU physicians utilize direct laryngoscopy with a Macintosh blade as a primary device for EETI and an extraglottic device as a backup strategy. This survey highlights variation in Canadian practice patterns for some aspects of intubation in critically ill patients.
Zika Virus: A Review of Management Considerations and Controversies at Six Months
Authors: Singer Laura , Vest Kelly G. , Beadling Charles W. 
Published: August 2016

AbstractZika virus continues to pose a significant global health threat. While the outbreak pattern may seemingly mirror those of other arboviruses, unique transmission characteristics and clinical outcomes warrant a different approach to traditional public health practices. Sexual transmission and virus-associated fetal and nonfetal neurologic disorders specifically challenge conventional methods of disease protection and prevention with regard to vector control, disease surveillance, and health risk communication. The protocols for outbreak and case limitation led by the World Health Organization (in accordance with Public Health Emergency of International Concern declaration) may be augmented by localized risk categorization and assignment for Zika and future emergent outbreaks. There is currently a great deal of “behind the scenes” discussion about modifications to the formal process described in the International Health Regulations. A scalable, adaptable, and flexible process is needed that can be customized to a specific threat. (Disaster Med Public Health Preparedness. 2017;11:279–284)
Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014
Authors: Weiner Lindsey M. , Webb Amy K. , Limbago Brandi , Dudeck Margaret A. , Patel Jean , Kallen Alexander J. , Edwards Jonathan R. , Sievert Dawn M. 
Published: August 2016

OBJECTIVETo describe antimicrobial resistance patterns for healthcare-associated infections (HAIs) that occurred in 2011–2014 and were reported to the Centers for Disease Control and Prevention’s National Healthcare Safety Network.METHODSData from central line–associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonias, and surgical site infections were analyzed. These HAIs were reported from acute care hospitals, long-term acute care hospitals, and inpatient rehabilitation facilities. Pooled mean proportions of pathogens that tested resistant (or nonsusceptible) to selected antimicrobials were calculated by year and HAI type.RESULTSOverall, 4,515 hospitals reported that at least 1 HAI occurred in 2011–2014. There were 408,151 pathogens from 365,490 HAIs reported to the National Healthcare Safety Network, most of which were reported from acute care hospitals with greater than 200 beds. Fifteen pathogen groups accounted for 87% of reported pathogens; the most common included Escherichia coli (15%), Staphylococcus aureus (12%), Klebsiella species (8%), and coagulase-negative staphylococci (8%). In general, the proportion of isolates with common resistance phenotypes was higher among device-associated HAIs compared with surgical site infections. Although the percent resistance for most phenotypes was similar to earlier reports, an increase in the magnitude of the resistance percentages among E. coli pathogens was noted, especially related to fluoroquinolone resistance.CONCLUSIONThis report represents a national summary of antimicrobial resistance among select HAIs and phenotypes. The distribution of frequent pathogens and some resistance patterns appear to have changed from 2009–2010, highlighting the need for continual, careful monitoring of these data across the spectrum of HAI types.Infect Control Hosp Epidemiol 2016;1–14
On the equatorial Ekman layer
Authors: Marcotte Florence , Dormy Emmanuel , Soward Andrew 
Published: August 2016

The steady incompressible viscous flow in the wide gap between spheres rotating rapidly about a common axis at slightly different rates (small Rossby number) has a long and celebrated history. The problem is relevant to the dynamics of geophysical and planetary core flows, for which, in the case of electrically conducting fluids, the possible operation of a dynamo is of considerable interest. A comprehensive asymptotic study, in the small Ekman number limit $E\ll 1$, was undertaken by Stewartson (J. Fluid Mech., vol. 26, 1966, pp. 131–144). The mainstream flow, exterior to the $E^{1/2}$ Ekman layers on the inner/outer boundaries and the shear layer on the inner sphere tangent cylinder $\mathscr{C}$, is geostrophic. Stewartson identified a complicated nested layer structure on $\mathscr{C}$, which comprises relatively thick quasigeostrophic $E^{2/7}$- (inside $\mathscr{C}$) and $E^{1/4}$- (outside $\mathscr{C}$) layers. They embed a thinner ageostrophic $E^{1/3}$ shear layer (on $\mathscr{C}$), which merges with the inner sphere Ekman layer to form the $E^{2/5}$-equatorial Ekman layer of axial length $E^{1/5}$. Under appropriate scaling, this $E^{2/5}$-layer problem may be formulated, correct to leading order, independent of $E$. Then the Ekman boundary layer and ageostrophic shear layer become features of the far-field (as identified by the large value of the scaled axial coordinate $z$) solution. We present a numerical solution of the previously unsolved equatorial Ekman layer problem using a non-local integral boundary condition at finite $z$ to account for the far-field behaviour. Adopting $z^{-1}$ as a small parameter we extend Stewartson’s similarity solution for the ageostrophic shear layer to higher orders. This far-field solution agrees well with that obtained from our numerical model.
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine
Authors: Brand Sarel Jacobus , Harvey Brian Herbert 
Published: August 2016

ObjectiveCo-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to produce an animal with more severe as well as treatment-resistant depressive-like behaviours.MethodsMale Flinders sensitive line (FSL) rats, a genetic animal model of depression, were exposed to a stress re-stress model of PTSD [time-dependent sensitisation (TDS)] and compared with stress-naive controls. Seven days after TDS stress, depressive-like and coping behaviours as well as hippocampal and cortical noradrenaline (NA) and 5-hydroxyindoleacetic acid (5HIAA) levels were analysed. Response to sub-chronic imipramine treatment (IMI; 10 mg/kg s.c.×7 days) was subsequently studied.ResultsFSL rats demonstrated bio-behavioural characteristics of depression. Exposure to TDS stress in FSL rats correlated negatively with weight gain, while demonstrating reduced swimming behaviour and increased immobility versus unstressed FSL rats. IMI significantly reversed depressive-like (immobility) behaviour and enhanced active coping behaviour (swimming and climbing) in FSL rats. The latter was significantly attenuated in FSL rats exposed to TDS versus unstressed FSL rats. IMI reversed reduced 5HIAA levels in unstressed FSL rats, whereas exposure to TDS negated this effect. Lowered NA levels in FSL rats were sustained after TDS with IMI significantly reversing this in the hippocampus.ConclusionCombining a gene-X-environment model of depression with a PTSD paradigm produces exaggerated depressive-like symptoms that display an attenuated response to antidepressant treatment. This work confirms combining FSL rats with TDS exposure as a putative animal model of TRD.
Dawes Review 5: Australian Aboriginal Astronomy and Navigation
Authors: Norris Ray P. 
Published: August 2016

AbstractThe traditional cultures of Aboriginal Australians include a significant astronomical component, perpetuated through oral tradition, ceremony, and art. This astronomical knowledge includes a deep understanding of the motion of objects in the sky, which was used for practical purposes such as constructing calendars and for navigation. There is also evidence that traditional Aboriginal Australians made careful records and measurements of cyclical phenomena, recorded unexpected phenomena such as eclipses and meteorite impacts, and could determine the cardinal points to an accuracy of a few degrees. Putative explanations of celestial phenomena appear throughout the oral record, suggesting traditional Aboriginal Australians sought to understand the natural world around them, in the same way as modern scientists, but within their own cultural context. There is also a growing body of evidence for sophisticated navigational skills, including the use of astronomically based songlines. Songlines are effectively oral maps of the landscape, and are an efficient way of transmitting oral navigational skills in cultures that do not have a written language. The study of Aboriginal astronomy has had an impact extending beyond mere academic curiosity, facilitating cross-cultural understanding, demonstrating the intimate links between science and culture, and helping students to engage with science.
The Ursa Major Cluster Redefined as a ‘Supergroup’
Authors: Wolfinger K. , Kilborn V. A. , Ryan-Weber E. V. , Koribalski B. S. 
Published: August 2016

AbstractWe identify gravitationally bound structures in the Ursa Major region using positions, velocities and photometry from the Sloan Digital Sky Survey (SDSS DR7) and the Third Reference Catalogue of Bright Galaxies (RC3). A friends-of-friends algorithm is extensively tested on mock galaxy lightcones and then implemented on the real data to determine galaxy groups whose members are likely to be physically and dynamically associated with one another. We find several galaxy groups within the region that are likely bound to one another and in the process of merging. We classify 6 galaxy groups as the Ursa Major ‘supergroup’, which are likely to merge and form a poor cluster with a mass of ~ 8 × 1013 M⊙. Furthermore, the Ursa Major supergroup as a whole is likely bound to the Virgo cluster, which will eventually form an even larger system in the context of hierarchical structure formation. We investigate the evolutionary state of the galaxy groups in the Ursa Major region and conclude that these groups are in an early evolutionary state and the properties of their member galaxies are similar to those in the field.
Interwoven Strands for Refining the Chronology of the Neolithic Tell of Vinča-Belo Brdo, Serbia
Authors: Tasić Nenad , Marić Miroslav , Filipović Dragana , Penezić Kristina , Dunbar Elaine , Reimer Paula , Barclay Alistair , Bayliss Alex , Gaydarska Bisserka , Whittle Alasdair 
Published: August 2016

AbstractA formally modeled radiocarbon chronology for a new profile through the great Neolithic tell of Vinča-Belo Brdo, Serbia, is the third interwoven strand in refining the chronology of the tell. This now joins models for the whole sequence based on the archive of early excavations, and for the last two known horizons at the top of the settlement mound, investigated in recent decades. In the new deep sounding, Vinča culture occupation from the 52nd century cal BC is slightly later than in the main sequence, probably reflecting the horizontal extension of the tell as it began to grow. The last dated occupation falls in the late 47th–early 46th century cal BC, slightly earlier than in the main sequence, but the top of the profile is affected by the slippage that caused the new excavations. Formal estimates are given for the succession and varying durations of burnt and unburnt houses, and indicate a period in the first part of the 5th millennium without house burning. Overall, the combined results from the three interwoven strands serve to produce a radically enhanced understanding of the temporality of the tell, which builds on, rather than supplants, previous research. We knew previously that Vinča-Belo Brdo was very long-lived, but now we can time that history with much greater precision. We can assert with much greater confidence that its vertical buildup was steady and largely uninterrupted. We have begun, from the work on the top of the tell and in the new deep sounding, to grasp better the fluctuations in house durations from generation to generation, and can now contrast the relative fortunes of unburnt and burnt houses. We can say much more about the timing and tempo of the ending of the tell, and about the possible circumstances in which that took place.
Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase α, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge
Authors: Wang Xiuying , Liu Yulan , Wang Shuhui , Pi Dingan , Leng Weibo , Zhu Huiling , Zhang Jing , Shi Haifeng , Li Shuang , Lin Xi , Odle Jack 
Published: August 2016

AbstractPro-inflammatory cytokines are critical in mechanisms of muscle atrophy. In addition, asparagine (Asn) is necessary for protein synthesis in mammalian cells. We hypothesised that Asn could attenuate lipopolysaccharide (LPS)-induced muscle atrophy in a piglet model. Piglets were allotted to four treatments (non-challenged control, LPS-challenged control, LPS+0·5 % Asn and LPS+1·0 % Asn). On day 21, the piglets were injected with LPS or saline. At 4 h post injection, piglet blood and muscle samples were collected. Asn increased protein and RNA content in muscles, and decreased mRNA expression of muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1). However, Asn had no effect on the protein abundance of MAFbx and MuRF1. In addition, Asn decreased muscle AMP-activated protein kinase (AMPK) α phosphorylation, but increased muscle protein kinase B (Akt) and Forkhead Box O (FOXO) 1 phosphorylation. Moreover, Asn decreased the concentrations of TNF-α, cortisol and glucagon in plasma, and TNF-α mRNA expression in muscles. Finally, Asn decreased mRNA abundance of muscle toll-like receptor (TLR) 4 and nucleotide-binding oligomerisation domain protein (NOD) signalling-related genes, and regulated their negative regulators. The beneficial effects of Asn on muscle atrophy may be associated with the following: (1) inhibiting muscle protein degradation via activating Akt and inactivating AMPKα and FOXO1; and (2) decreasing the expression of muscle pro-inflammatory cytokines via inhibiting TLR4 and NOD signalling pathways by modulation of their negative regulators.
Do nymphs and adults of three Neotropical zoophytophagous mirids damage leaves and fruits of tomato?
Authors: Silva D.B. , Bueno V.H.P. , Calvo F.J. , van Lenteren J.C. 
Published: August 2016

AbstractThe predatorsMacrolophus basicornis(Stal),Engytatus varians(Distant) andCampyloneuropsis infumatus(Carvalho) consume large numbers of tomato pests such asBemisia tabaci(Gennadius) andTuta absoluta(Meyrick). However, they are zoophytophagous and feed on plant parts as well. We evaluated the type and effect of injury caused by nymphs and adults of these mirids on tomato seedlings and fruit in the absence of prey. For each mirid species, seedlings were exposed to groups of 20 nymphs or adults for 72 h, and fruits were exposed for 48 h to groups of four nymphs or adults. Type and the number of injury on stems, petioles and leaflets of tomato seedlings and fruits were recorded after removal of insects. Nymphs and adults of these mirids caused necrotic rings on the leaflets, but no injury was observed on stem and petioles. The necrotic rings on leaflets consisted of blemishes, characterized by feeding punctures surrounded by a yellowish, bleached area. The number of necrotic rings did not exceed one per individual mirid and seedlings developed normally. Nymphs also caused feeding punctures on tomato fruit, but in even lower numbers than on leaflets. Two weeks after the start of the experiment the tomato fruit still looked fresh and feeding punctures had disappeared. Adults did not cause any injury to tomato fruit. The results indicate that nymphs and adults of these zoophytophagous mirids cause little injury to tomato seedlings and fruit, even when present in high densities and in the absence of prey, making them interesting candidates for biological control.
Reassessment of the Mesozoic metasedimentary rocks and tectonic setting of Taiwan and the adjacent continental margin of eastern Asia
Authors: WANG YU , TSAI CHIN-HO , ZHOU LIYUN , QIU YAN , SUN GUIHUA 
Published: August 2016

AbstractIt remains unclear whether a crystalline basement exists in SE China (including Taiwan), whether the formation of the Tananao metamorphic belt in Taiwan was linked to subduction of the Palaeo-Pacific Plate, and whether the source rocks of the sedimentary sequences in the metamorphic belts are late Mesozoic or Palaeozoic in age. Field investigations and zircon age data in the present study indicate that there is no pre-Palaeozoic gneiss (crystalline basement) in Taiwan (although orthogneisses were produced during deformation and metamorphism of Mesozoic granites), and investigations of the metasediments show that the sedimentary sequences in the Tailuko and Yuli belts are similar. Moreover, LA-ICP-MS dating of detrital zircons from the Pingtan–Dongshan belt in Fujian Province yields a cluster of 206Pb–238U ages at ~ 210–190 Ma, and the Tailuko and Yuli belts in Taiwan have similar clusters of detrital zircon ages at 200 Ma, 160 Ma, 120 Ma and 110 Ma, as well as a later overprinting caused by arc–continent collision. The cathodoluminescence images and trace-element characteristics of the zircons show that they were originally magmatic in origin. This finding, combined with the Hf isotope data, indicates that the sources of sediments in the Tananao belt (Tailuko and Yuli belts) were relatively close to an active continental margin, and that both the Tailuko and Yuli belts have similar sedimentary sources. From the margin of the Chinese mainland to Taiwan, the metasediments seem to represent a continuous sequence of deposits ranging in age from Jurassic to Cretaceous, but with the sediments becoming progressively younger towards the east. It can be inferred that the sediments in the Tailuko and Yuli belts were continental-shelf sequences with sources in SE China.
Estimating crop water deficit during maize potential growth period and climatic sensitivity analysis in Northeast China, 1961–2010
Authors: LIU B. C. , LIU Y. , YANG F. , YANG X. J. , BAI W. 
Published: August 2016

SUMMARYOne of the probable adverse effects of climate change on agriculture is yield loss due to water scarcity. Assessment of meteorological drought risk with the index of crop water deficit (CWD) can help in determining appropriate adaptation strategies to counter such losses. Using daily weather data from 68 stations in Northeast China (NEC) for 1961–2010, the spatial and temporal behaviour ofCWDwas assessed and the sensitivity of climatic variables related toCWDduring the potential growth period of maize was explored. The results indicated that the potential maize growth period decreased by 26 days due to climate warming. The deficit (i.e. a negative value for water demand) decreased from east to west and decreased gradually during 1978–1984 and sharply during 2000–2010. It is noteworthy that NEC experienced severe droughts especially in the 1970s and the 2000s, and relative humidity was the most sensitive parameter affecting evapotranspiration. Regions in the middle of Heilongjiang and Jilin should take precautions concerning climate change effects onCWD, while the northern part of NEC should take precautions concerning changes in temperature and sunshine hours. Growing late-maturing and drought-tolerant maize varieties is therefore a good option for higher production in NEC, coupled with enhancing the availability of water in this limited-rainfall region, and should form a part of the strategy to cope with climate change.