bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal Stem Cells and Cardiomyocytes Interplay to Prevent Myocardial Hypertrophy
Authors: Cai Benzhi , Tan Xueying , Zhang Yong , Li Xingda , Wang Xinyue , Zhu Jiuxin , Wang Yang , Yang Fan , Wang Baoqiu , Liu Yanju , Xu Chaoqian , Pan Zhenwei , Wang Ning , Yang Baofeng , Lu Yanjie 
Published: December 2015

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) have emerged as a promising therapeutic strategy for cardiovascular disease. However, there is no evidence so far that BMSCs can heal pathological myocardial hypertrophy. In this study, BMSCs were indirectly cocultured with neonatal rat ventricular cardiomyocytes (NRVCs) in vitro or intramyocardially transplanted into hypertrophic hearts in vivo. The results showed that isoproterenol (ISO)-induced typical hypertrophic characteristics of cardiomyocytes were prevented by BMSCs in the coculture model in vitro and after BMSC transplantation in vivo. Furthermore, activation of the Ca2+/calcineurin/nuclear factor of activated T cells cytoplasmic 3 (NFATc3) hypertrophic pathway in NRVCs was abrogated in the presence of BMSCs both in vitro and in vivo. Interestingly, inhibition of vascular endothelial growth factor (VEGF) release from BMSCs, but not basic fibroblast growth factor and insulin-like growth factor 1, abolished the protective effects of BMSCs on cardiomyocyte hypertrophy. Consistently, VEGF administration attenuated ISO-induced enlargement of cellular size; the upregulation of atrial natriuretic peptide, brain natriuretic peptide, and β-myosin heavy chain expression; and the activation of Ca2+/calcineurin/NFATc3 hypertrophic pathways, and these pathways can be abrogated by blocking VEGFR-1 in cardiomyocytes, indicating that VEGF receptor 1 is involved in the antihypertrophic role of VEGF. We further found that the ample VEGF secretion contributing to the antihypertrophic effects of BMSCs originates from the crosstalk of BMSCs and cardiac cells but not BMSCs or cardiomyocytes alone. Interplay of mesenchymal stem cells with cardiomyocytes produced synergistic effects on VEGF release. In summary, crosstalk between mesenchymal stem cells and cardiomyocytes contributes to the inhibition of myocardial hypertrophy via inhibiting Ca2+/calcineurin/NFATc3 hypertrophic pathways in cardiac cells. These results provide the first evidence for the treatment of myocardial hypertrophy using BMSCs.

Significance
This study found that mesenchymal stem cells may crosstalk with cardiomyocytes, which causes a synergistic vascular endothelial growth factor (VEGF) release from both kinds of cells and then inhibits pathological cardiac remodeling following hypertrophic stimulation in cardiomyocytes in vitro and in vivo. Blockage of VEGF release from bone marrow-derived mesenchymal stem cells (BMSCs) abolishes the antihypertrophic actions of BMSCs in vitro and in vivo. On the contrary, VEGF administration attenuates hypertrophic signaling of calcineurin/ nuclear factor of activated T cell cytoplasmic 3 signal pathways. This study provides the first evidence for the treatment of myocardial hypertrophy using BMSCs.
Contenidos y procesos en pedagogía social: deconstrucción de la última etapa de producción
Authors: Rabadán Rubio José Antonio , Hernández Pérez Encarnación 
Published: December 2015

A la hora de abordar los contenidos y procesos de la Pedagogía Social es claro indicar que no estamos ante un asunto baladí ni sencillo, ya que es un saber en permanente construcción. En la mayoría de los casos, la praxis va muy por delante de la reflexión teórica e incluso, la acción, debería tener un peso más relevante que la propia teoría. A pesar de las dificultades planteadas, nuestro objetivo en este artículo es el de analizar la producción científica realizada por los profesionales orientados al ámbito de la Pedagogía Social<br />en nuestro país, por medio de sus órganos de expresión más relevantes, Revista Interuniversitaria de Pedagogía Social y Seminario Interuniversitario de Pedagogía Social. Para ello, revisaremos investigaciones, contenidos y procesos de la disciplina planteando así un breve recorrido de la última etapa en la producción científica de esta disciplina. Con ello, pretendemos proporcionar un conocimiento objetivo y científico sobre el desarrollo de esta ciencia pedagógica, su realidad actual y sus nuevos retos ante las dinámicas sociales imperantes.
Música, movimiento y danza: un enfoque integrador para la formación inicial del profesorado
Authors: Sánchez Ariño Silvia , Cañabate Ortiz Dolors , Calbó Angrill Montserrat , Viscarro Tomás Isabel 
Published: December 2015

La consideración del cuerpo y del movimiento como medios de expresión y comprensión musical tendría que formar parte de una educación musical activa y vivencial. El estudio que se ha llevado a término describe cómo se integra y desarrolla el trabajo del movimiento y la danza en las sesiones de educación musical de 19 escuelas a partir de las observaciones e intervenciones de estudiantes de Magisterio Musical en prácticas. Las conclusiones del estudio apuntan a que, si bien hay una cierta integración del movimiento y la danza en la educación musical, es necesario mejorar aspectos como el del trabajo de la improvisación y la composición corporal, ambos instrumentos imprescindibles para el desarrollo de las capacidades creativas y comunicativas del alumnado.
Hermenéutica de la educación y nuevas fronteras entre las diferencias
Authors: González Pérez Teresa , Gramigna Anita 
Published: December 2015

Pretendemos trazar a lo largo de este trabajo las líneas de la epistemología del pensamiento narrativo, una vez aclarado que el pensamiento científico se sirve de representaciones unidas por las narraciones. Nuestro intento surge de la exigencia por clarificar qué es lo que está implícito, cuáles las premisas de nuestra mirada, de nuestra investigación, porque el resultado de nuestro proceder tiene mucho que ver con aquello que está implícito, con las premisas. Estudiar las representaciones de la técnica y de la ciencia nos pueden ayudar a comprender la estructura de los razonamientos y procedimientos que han llevado a grandes descubrimientos y que también han abierto nuestro futuro a riesgos inquietantes, sobre todo cuando parece minar el equilibrio que rige las relaciones dinámicas de la vida sobre el planeta. La experiencia humana y, por tanto, las prácticas relacionadas con la formación, revisten un carácter esencialmente interpretativo que nos incita, en la investigación pedagógica, como en la práctica educativa, a un esfuerzo de comprensión, antes que a la explicación de los fenómenos. Partimos de una hermenéutica deconstructiva que vence tanto el determinismo de las reconstrucciones a posteriori, como el nihilismo de la secularización. Pensamos en una narración que interpreta al otro como parte de sí mismo, semilla fecunda de una relacionalidad que representa el principio ontológico de la hermenéutica educativa. El proceso constructivo de los pensamientos, sentimientos,<br />acciones, símbolos, estética, juicios morales, junto con otros, nos involucran y nos transforman en la aventura del conocimiento. El concepto de diferencia se asume como fundamentación educativa. Sin embargo, sin diferencia no puede existir la relación y, en consecuencia, tampoco la educación.
L’ambivalence de la transmission des normes du genre par les mères lesbiennes : de la critique des stéréotypes à leur reproduction « pour le bien de l’enfant »
Authors: Frémont Camille 
Published: December 2015

Ce travail s’appuie sur des récits de mères lesbiennes recueillis dans le cadre d’un travail de recherche en sociologie, mené en France, sur la transmission du genre dans les familles lesboparentales. Ce travail visait à répondre à la question suivante : quelles représentations ont les mères lesbiennes ont-elles des normes du genre et de la socialisation de genre de leurs enfants ?
D’un point de vue individuel, les enquêtées démontrent une réelle remise en question des normes du genre. Elles manifestent un détachement de la pensée hétéronormative par une critique des stéréotypes de genre, une dénonciation du sexisme et une certaine « déshétérosexualisation » dans la manière de parler de soi et dans leur apparence. Le fonctionnement des couples au quotidien montre une plus grande égalité que dans le modèle hétérosexuel traditionnel de l’organisation domestique et des rôles parentaux.
Elles développent des discours présentant leur mode de vie sous un jour positif et dans lesquels elles affirment de manière argumentée la non-nécessité de la différence des sexes au niveau du couple parental. Ces arguments se retrouvent dans les récits de conception qu’elles construisent pour leurs enfants, afin que ceux-ci se structurent à partir d’une vision valorisante de leur famille. Les récits de conception proposent une définition de la famille dans laquelle procréation et conjugalité sont dissociées. En revanche, leur sentiment de légitimité semble rester vulnérable face à l’homophobie latente, non explicitement hostile, dont elles citent, en les minimisant, les nombreuses conséquences au quotidien.
Aussi, bien que prédisposées à transmettre des modèles d’identification éloignés des stéréotypes de genre, les mères lesbiennes interrogées sont attentives à promouvoir auprès de leurs enfants les signes d’une socialisation de genre normative, afin de les protéger de la désapprobation sociale à laquelle elles ont le sentiment de les exposer par leur modèle familial atypique. Elles leur apprennent à maîtriser les arguments qui leur permettront de se présenter de manière lisible et acceptable socialement.
High-level simulation of concurrency operations in microthreaded many-core architectures
Authors: Uddin Irfan 
Published: December 2015

AbstractComputer architects are always interested in analyzing the complex interactions amongst the dynamically allocated resources. Generally a detailed simulator with a cycle-accurate simulation of the execution time is used. However, the cycleaccurate simulator can execute at the rate of 100K instructions per second, divided over the number of simulated cores. This means that the evaluation of a complex application with complex concurrency interactions on contemporary multi-core machine can be very slow. To perform efficient design space exploration we present a co-simulation environment, where the detailed execution of concurrency instructions in the pipeline of microthreaded cores and the interactions amongst the hardware components are abstracted. We present the evaluation of the high-level simulation framework against the cycle-accurate simulation framework. The results show that high-level simulator is faster and less complicated than cycle-accurate simulator and has reasonable accuracy.
An evaluation of community pharmacy-based services for type 2 diabetes in an Indonesian setting: patient survey
Authors: Wibowo Yosi , Parsons Richard , Sunderland Bruce , Hughes Jeffery 
Published: December 2015

Background.Diabetes is an emerging chronic disease in developing countries. Its management in developing countries is mainly hospital/clinic based. The increasing diabetes burden in developing countries provides opportunities for community pharmacists to deliver a range of services. Since the management of diabetes requires the patient’s own involvement, it is important to gain their views in order to develop pharmacy-based diabetes services. Studies on diabetes patients’ views have been limited to developed countries.Objectives.To investigate, within a developing country setting (Indonesia), current use of pharmacy services by type 2 diabetes patients, and to evaluate their views regarding community pharmacists’ roles, and the characteristics that influence their views.Methods.A questionnaire survey was conducted within 10 purposefully selected community pharmacies in Surabaya, Indonesia. Each pharmacy recruited approximately 20 patients seeking antidiabetic medications. Usage of pharmacy services was identified using binary responses (‘yes’/‘no’) and views on pharmacists’ roles were rated using Likert scales; an open-ended question was used to identify patient perceived priority roles. Logistic regression models were used to determine characteristics associated with patients’ views.Results.A total of 196 pharmacy patients with type 2 diabetes responded (58.3% response rate). Most patients used community pharmacies for dispensing (100%) and education on how to use medications (79.6%). There were mixed views towards pharmacists providing services beyond dispensing. The highest priorities identified were from the ‘patient education’ domain: education on medications (i.e., directions for use (64.5%), storage (26.6%), common/important adverse effects (25.5%)); and the ‘monitoring’ domain: monitoring medication compliance (37.3%). Patients with higher incomes or who were working were less supportive of these expanded services, whereas patients who previously used a service, those with risk factors for complications or having poor/unknown glycaemic control were more supportive.Conclusions.Community pharmacies in Surabaya, Indonesia in this study were mainly utilised for dispensing. However, many type 2 diabetes patients using these pharmacies report limited monitoring of blood glucose levels and poor glycaemic control, which indicates an opportunity for greater pharmacist involvement. Yet for this to occur, patients’ limited expectations of pharmacists roles will need to be broadened. Characteristics influencing these views should inform the development of pharmacy-based diabetes services in the environment of the burgeoning burden of diabetes.
Establishing the role of honest broker: bridging the gap between protecting personal health data and clinical research efficiency
Authors: Choi Hyo Joung , Lee Min Joung , Choi Chang-Min , Lee JaeHo , Shin Soo-Yong , Lyu Yungman , Park Yu Rang , Yoo Soyoung 
Published: December 2015

Background.The objective of this study is to propose the four conditions for the roles of honest brokers through a review of literature published by ten institutions that are successfully utilizing honest brokers. Furthermore, the study aims to examine whether the Asan Medical Center’s (AMC) honest brokers satisfy the four conditions, and examine the need to enhance their roles.Methods.We analyzed the roles, tasks, and types of honest brokers at 10 organizations by reviewing the literature. We also established a Task Force (TF) in our institution for setting the roles and processes of the honest broker system and the honest brokers. The findings of the literature search were compared with the existing systems at AMC—which introduced the honest broker system for the first time in Korea.Results.Only one organization employed an honest broker for validating anonymized clinical data and monitoring the anonymity verifications of the honest broker system. Six organizations complied with HIPAA privacy regulations, while four organizations did not disclose compliance. By comparing functions with those of the AMC, the following four main characteristics of honest brokers were determined: (1) de-identification of clinical data; (2) independence; (3) checking that the data are used only for purposes approved by the IRB; and (4) provision of de-identified data to researchers. These roles were then compared with those of honest brokers at the AMC.Discussion.First, guidelines that regulate the definitions, purposes, roles, and requirements for honest brokers are needed, since there are no currently existing regulations. Second, Korean clinical research institutions and national regulatory departments need to reach a consensus on a Korean version of Limited Data Sets (LDS), since there are no lists that describe the use of personal identification information. Lastly, satisfaction surveys on honest brokers by researchers are necessary to improve the quality of honest brokers.
Assessing the ability of Pleiades stereo imagery to determine height changes in earthquakes: A case study for the El Mayor‐Cucapah epicentral area
Authors: Zhou Yu , Parsons Barry , Elliott John R , Barisin Ivana , Walker Richard T 
Published: December 2015

AbstractHigh‐resolution surface topography is valuable for studying coseismic fault zone deformation and fault geometry. It enables us to measure three‐dimensional surface displacements in earthquakes, as shown in recent studies that used light detection and ranging (lidar) to determine coseismic motion. However, the applicability of lidar is limited by its relatively high cost and low availability. In this study, we use the 2010 El Mayor‐Cucapah earthquake to demonstrate the capability of Pleiades stereo imagery to measure coseismic vertical ground displacement. We acquired post‐earthquake Pleiades tristereo imagery from backward, near‐nadir, and forward orientations for a 45 km × 7 km portion of the epicentral area. One meter resolution digital elevation models (DEMs) were produced with the four different combinations of incidence angles and compared to the post‐earthquake lidar DEM. Elevations from tristereo have slightly (∼15%) smaller uncertainties than bistereo as the tristereo DEM incorporates more observations. Elevation differences between the Pleiades and post‐earthquake lidar DEMs show that the vertical accuracy of the Pleiades DEMs is ∼0.3 m. By differencing the Pleiades DEM and the pre‐earthquake, 5 m resolution lidar DEM, we mapped meter and submeter offsets along the faults obtaining results comparable to a previous study that differenced the two lidar DEMs. This is the first case study of assessing very high resolution (VHR) satellite stereo imagery to determine submeter vertical ground displacement in an earthquake. By extension, we expect it to be possible to measure submeter vertical offsets occurring in earthquakes using pre‐earthquake and post‐earthquake VHR stereo imagery.
Rain effects on the hurricane observations over the ocean by C‐band Synthetic Aperture Radar
Authors: Zhang Guosheng , Li Xiaofeng , Perrie William , Zhang Biao , Wang Lei 
Published: December 2015

AbstractA composite radar scattering model composed of the atmosphere radiative transfer model, and the ocean surface Bragg wave theory is developed to analyze the impact of hurricane rain on the normalized radar‐backscatter cross section (NRCS) measured in the VV and cross‐polarized C‐band Synthetic Aperture Radar (SAR) channels. The model results are validated against SAR and SFMR measured wind speeds and rain rates for two hurricane cases. The contribution of rain to the NRCS is backscatter from two parts: the atmosphere column and the ocean surface. In the atmosphere, microwave attenuation and the rain‐induced volume backscattering are simulated by the model. We find that the impact of raindrops in the atmosphere is almost negligible for the VV polarization, but important for the cross polarization. On the ocean surface, comparisons between our model and other existing models without rain lead to the conclusion that the VV polarization NRCS can be simulated reasonably well without considering the non‐Bragg scattering mechanisms. Similar to the wave breaking mechanism, the microwave diffraction on the craters, crowns, and stalks, produced by rain drops, is also negligible for VV polarization. However, the non‐Bragg scattering is important for the cross‐polarized NRCS simulations. Finally, we performed simulations to understand the VV‐polarized NRCS behavior under different wind speeds at various rain rates.
Wave dynamics of a Pacific Atoll with high frictional effects
Authors: Rogers Justin S. , Monismith Stephen G. , Koweek David A. , Dunbar Robert B. 
Published: December 2015

AbstractWe report field measurements of waves and currents made from September 2011 to July 2014 on Palmyra Atoll in the central Pacific that were used in conjunction with the SWAN wave model to characterize the wave dynamics operant on the atoll. Our results indicate that wave energy is primarily from the north during the northern hemisphere winter and from the south in the northern hemisphere summer. Refraction of waves along the reef terraces due to variations in bathymetry leads to focusing of waves in specific locations. Bottom friction, modeled with a modified bottom roughness formulation, is the significant source of wave energy dissipation on the atoll, a result that is consistent with available observations of wave damping on Palmyra. Indeed modeled wave dissipation rates from bottom friction are on average larger than dissipation rates due to breaking and are an order of magnitude larger than what has been observed on other, less geometrically complex reefs, a result which should be corroborated with future in situ measurements. The SWAN wave model with a modified bottom friction formulation better predicts bulk wave energy properties than the existing formulation at our measurement stations. The near bed squared velocity, a proxy for bottom stress, shows strong spatial variability across the atoll and exerts control over geomorphic structure and benthic community composition.
Parameterization of intrawave ripple‐averaged sediment pickup above steep ripples
Authors: Amoudry L. O. , Souza A. J. , Thorne P. D. , Liu P. L.‐F. 
Published: December 2015

AbstractNear‐bed sediment pickup is critical for predictions of intrawave suspension and in turn net sediment transport in coastal models. In the present study, numerical results from a two‐dimensional Reynolds‐averaged Navier‐Stokes model are used to assess the functional relationship of intrawave ripple‐averaged sediment pickup above steep ripples. The numerical model provides intrawave time histories of ripple‐averaged near‐bed velocities and turbulence, which are qualitatively interrogated to determine pickup functional relationships. Several specific sediment pickup formulations are implemented within the numerical model: expressions relating pickup to near‐bed velocity or near‐bed turbulent kinetic energy via the bed shear stress; and expressions relating pickup to near‐bed shear production of turbulent kinetic energy. These are then tested via model‐data comparisons of near‐bed suspended sediment concentration. The results show that the traditional functions relating sediment pickup to near‐bed velocity cannot lead to reasonable intrawave suspension predictions above vortex ripples under a ripple‐averaged framework. Instead, relating sediment pickup to near‐bed turbulence quantities, such as turbulent kinetic energy or shear production of turbulent kinetic energy, significantly improves the numerical predictions for these conditions.
Mobile mud dynamics in the East China Sea elucidated using 210Pb, 137Cs, 7Be, and 234Th as tracers
Authors: Wang Jinlong , Du Jinzhou , Baskaran Mark , Zhang Jing 
Published: December 2015

Abstract“Mobile mud” (MM), which has fine grain size distribution (>90% clay + silt, and <5% sand) and high porosity (≥0.50), plays an important role in the biogeochemical cycles in the estuarine areas and the inshore shelf. A suite of MM samples from the coastal area of the East China Sea (ECS) was collected in spring and summer of 2011 to observe their spatial and temporal distribution, grain size, and radionuclides concentrations. The MM thickness ranged from 0.5 to 11 cm (average: 2.2 cm (May) and 3.9 cm (August)). The thick mud layer is mainly distributed along the coast, with an area of 2.2 × 104 km2 in May and 1.5 × 104 km2 in August, with corresponding masses of 8.8 × 108 and 7.8 × 108 t, respectively. The estimated masses of MM are considerably larger than the annual sediment discharge mass of the Changjiang River. The distribution of 137Cs inventories in MM indicates that 137Cs can be effectively utilized as a transport tracer of MM in the river‐dominated estuaries and coastal areas. The higher inventories of 7Be in MM in the river mouth in spring are attributed to higher depositional flux and higher sediment discharge. The ratio of the MM inventory of 234Thex/production in the overlying water column of >2.5 in south inshore indicates that the sediment focusing resulted in the increased mass flux. The residence time of MM is estimated as 3–6 years both by mass balance of MM and 210Pbex in MM.