bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of serial changes in diaphragm function during the spontaneous breathing trial for weaning outcome: a study protocol
Authors: Zhou Pengmin , Zhang Zhongheng , Hong Yucai , Cai Huabo , Zhao Hui , Xu Peifeng , Zhao Yiming , Lin Shengping , Qin Xuchang , Guo JiaWei , Pan Yun , Dai Junru 
Published: June 2017

IntroductionThere is a variety of tools being used in clinical practice for the prediction of weaning success from mechanical ventilation. However, their diagnostic performances are less than satisfactory. The purpose of this study is to investigate the value of serial changes in diaphragm function measured by ultrasound during the spontaneous breathing trial (SBT) as a weaning predictor.Methods and analysisThis is a prospective observational study conducted in a 10-bed medical emergency intensive care unit (EICU) in a university-affiliated hospital. The study will be performed from November 2016 to December 2017. All patients in the EICU who are expected to have mechanical ventilation for more than 48 hours through endotracheal tube are potentially eligible for this study. Patients will be included if they fulfil the criteria for SBT. All enrolled patients will be ventilated with an Evita-4 by using volume assist control mode prior to SBT. Positive end-expiratory pressure (PEEP) will be set to 5 cmH2O and fractional inspired oxygen (FiO2) will be set to a value below 0.5 that guarantees oxygen saturation by pulse oximetry (SpO2) greater than 90%. Enrolled patients will undergo SBT for 2 hours in semirecumbent position. During the SBT, the patients will breathe through the ventilator circuit by using flow triggering (2 L/min) with automatic tube compensation of 100% and 5 cmH2O PEEP. The FiO2will be set to the same value as used before SBT. If the patients fail to tolerate the SBT, the trial will be discontinued immediately and the ventilation mode will be switched to that used before the trial. Patients who pass the 2-hour SBT will be extubated. Right diaphragm excursion and bilateral diaphragm thickening fraction will be measured by ultrasonography during spontaneous breathing. Images will be obtained immediately prior to the SBT, and at 5, 30, 60, 90 and 120 min after the initiation of SBT. Rapid shallow breathing index will be simultaneously calculated at the bedside by a respiratory nurse.Ethics and disseminationThe study protocol is approved by the ethics committee of Sir Run Run Shaw Hospital, an affiliate of Zhejiang University, Medical College. The results will be published in a peer-reviewed journal and shared with the worldwide medical community.Trial registration numberISRCTN42917473; Pre-results.
The perspective of European researchers of national occupational safety and health institutes for contributing to a European research agenda: a modified Delphi study
Authors: Gagliardi Diana , Rondinone Bruna M , Mirabile Marco , Buresti Giuliana , Ellwood Peter , Hery Michel , Paszkiewicz Peter , Valenti Antonio , Iavicoli Sergio 
Published: June 2017

ObjectivesThis study, developed within the frame of the Partnership for European Research on Occupational Safety and Health joint research activities and based on the frame designed by the 2013 European Agency for Safety and Health at Work (EU-OSHA) study, is the first example of using the points of view of European occupational safety and health (OSH) researchers.The objective is to identify priorities for OSH research that may contribute to the achievement of present and future sustainable growth objectives set by the European strategies.MethodsThe study was carried out using a modified Delphi method with a two-round survey. Each round involved a panel of about 110 researchers representing the network member institutes was selected according to specific criteria, including the ownership of research expertise in at least one of the four macroareas identified by the reference report developed by EU-OSHA in 2013.ResultsThe study identified some innovative research topics (for example, ‘Emerging technological devices’ and ‘OSH consequences of markets integration’) and research priorities (ie, crowdsourcing, e-work, zero-hours contracts) that are not reflected in previous studies of this nature.The absence of any reference to violence and harassment at work among the researchers’ proposals is a major difference from previous similar studies, while topics related to gender issues and electromagnetic fields show a lower importance.ConclusionsThe innovative design of a research priorities identification process, which takes advantage of a large, representative and qualified panel of European researchers allowed the definition of a number of research priorities able to support the inclusion of innovative OSH research issues in the scope of the next European research agenda.
Protocol for the residents in action pilot cluster randomised controlled trial (RiAT): evaluating a behaviour change intervention to promote walking, reduce sitting and improve mental health in physically inactive older adults in retirement villages
Authors: Thøgersen-Ntoumani Cecilie , Wright Ashlene , Quested Eleanor , Burton Elissa , Hill Keith D , Cerin Ester , Biddle Stuart J H , Ntoumanis Nikos 
Published: June 2017

IntroductionAgeing is accompanied by increased risks of chronic disease, declined functioning and increased dependency. Physical activity is critical to retaining health and independence, but the majority of older people are insufficiently physically active to achieve these benefits and have high levels of sedentary (sitting) time. Activity programmes are often offered in retirement villages; however, their uptake is limited. Furthermore, although the physical environment in and around these villages can play an important role in decisions to be physically active, its role is often overlooked by research in these settings. We aim to develop, implement and evaluate a proof-of-concept motivationally embellished intervention designed to increase walking, reduce sitting and improve mental health in residents in retirement villages.Methods and analysisThis will be a 16-week pilot intervention using a cluster randomised design with retirement villages as the unit of randomisation and residents as the unit of assessment. Fourteen retirement villages around Perth, Western Australia, will be recruited for the intervention. Objective audits of neighbourhood environments around each village will be completed using the Pathway Environmental Audit Tool. Seven villages will be randomised to the experimental arm and seven to the control arm. Only participants in the experimental arm will receivemotivationaltraining. All outcomes will be assessed at baseline, end of intervention and 6-month follow-up. Changes in physical activity levels, sitting time and mental health will be examined. Multilevel modelling will be used to analyse the data. A mixed methods process evaluation will also be conducted.Ethics and disseminationEthics approval was granted by Curtin University’s Human Research Ethics Committee (HREC2016-0187). The results of the study will be disseminated via peer-reviewed publications, conference presentations and reports to, and seminars with, stakeholders.Trial registrationThe trial is registered with the Australian New Zealand Clinical Trials Registry: ACTRN12616001177448.
The impact of weight misperception on health-related quality of life in Korean adults (KNHANES 2007–2014): a community-based cross-sectional study
Authors: Park Susan , Lee Sejin , Hwang Jinseub , Kwon Jin-Won 
Published: June 2017

Background/objectivesWeight perception, especially misperception, might affect health-related quality of life (HRQoL); however, related research is scarce and results remain equivocal. We examined the association between HRQoL and weight misperception by comparing obesity level as measured by body mass index (BMI) and weight perception in Korean adults.MethodsStudy subjects were 43 883 adults aged 19 years or older from cycles IV (2007–2009), V (2010–2012) and VI (2013–2014) of the Korean National Health and Nutrition Examination Survey. Multiple regression analyses comprising both logit and tobit models were conducted to evaluate the independent effect of obesity level as measured by BMI, weight perception and weight misperception on HRQoL after adjusting for demographics, socioeconomic status and number of chronic diseases. We also performed multiple regressions to explore the association between weight misperception and HRQoL stratified by BMI status.ResultsObesity level as measured by BMI and weight perception were independently associated with low HRQoL in both separate and combined analyses. Weight misperception, including underestimation and overestimation, had a significantly negative impact on HRQoL. In subgroup analysis, subjects with BMI ranges from normal to overweight who misperceived their weight also had a high risk of low HRQoL. Overestimation of weight among obese subjects associated with low HRQoL, whereas underestimation of weight showed no significant association.ConclusionsBoth obesity level as measured by BMI and perceiving weight as fat were significant risk factors for low HRQoL. Subjects who incorrectly perceived their weight relative to their BMI status were more likely to report impaired HRQoL, particularly subjects with BMI in the normal to overweight range. Based on these findings, we recommend political and clinical efforts to better inform individuals about healthy weight status and promote accurate weight perception.
Work-related psychosocial factors and onset of metabolic syndrome among workers: a systematic review and meta-analysis protocol
Authors: Sakuraya Asuka , Watanabe Kazuhiro , Kawakami Norito , Imamura Kotaro , Ando Emiko , Asai Yumi , Eguchi Hisashi , Kobayashi Yuka , Nishida Norimitsu , Arima Hideaki , Shimazu Akihito , Tsutsumi Akizumi 
Published: June 2017

IntroductionMetabolic syndrome is an important public health target because of its high prevalence worldwide. Work-related psychosocial factors have been identified as determinants of metabolic syndrome components. However, there have been no systematic reviews or meta-analyses conducted to evaluate the relationship between work-related psychosocial factors and metabolic syndrome as an aggregated cluster. The aim of this study is to examine this association from published prospective studies.Methods and analysisThe systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, PsycINFO, PsycARTICLES and Japan Medical Abstracts Society). Studies that (1) examined the association between work-related psychosocial factors and the onset of metabolic syndrome, (2) had a longitudinal or prospective cohort design, (3) were conducted among workers, (4) provided sufficient data for calculating ORs or relative risk with a 95% CI, (5) were published as original articles written in English or Japanese, and (6) having been published until the end of 2016 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators.Ethics and disseminationEthics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. The findings from this study could be useful for assessing metabolic syndrome risk factors in the workplace, and determining approaches for prevention of metabolic syndrome in the future.Trial registration numberPROSPERO CRD42016039096 (http://www.crd.york.ac.uk/PROSPERO_REBRANDING/display_record.asp?ID=CRD42016039096)
A multicentre, randomised controlled, non-inferiority trial, comparing nasal high flow with nasal continuous positive airway pressure as primary support for newborn infants with early respiratory distress born in Australian non-tertiary special care nurseries (the HUNTER trial): study protocol
Authors: Manley Brett J , Roberts Calum T , Arnolda Gaston R B , Wright Ian M R , Owen Louise S , Dalziel Kim M , Foster Jann P , Davis Peter G , Buckmaster Adam G 
Published: June 2017

IntroductionNasal high-flow (nHF) therapy is a popular mode of respiratory support for newborn infants. Evidence for nHF use is predominantly from neonatal intensive care units (NICUs). There are no randomised trials of nHF use in non-tertiary special care nurseries (SCNs). We hypothesise that nHF is non-inferior to nasal continuous positive airway pressure (CPAP) as primary support for newborn infants with respiratory distress, in the population cared for in non-tertiary SCNs.Methods and analysisThe HUNTER trial is an unblinded Australian multicentre, randomised, non-inferiority trial. Infants are eligible if born at a gestational age ≥31 weeks with birth weight ≥1200 g and admitted to a participating non-tertiary SCN, are <24 hours old at randomisation and require non-invasive respiratory support or supplemental oxygen for >1 hour. Infants are randomised to treatment with either nHF or CPAP. The primary outcome is treatment failure within 72 hours of randomisation, as determined by objective oxygenation, apnoea or blood gas criteria or by a clinical decision that urgent intubation and mechanical ventilation, or transfer to a tertiary NICU, is required. Secondary outcomes include incidence of pneumothorax requiring drainage, duration of respiratory support, supplemental oxygen and hospitalisation, costs associated with hospital care, cost-effectiveness, parental stress and satisfaction and nursing workload.Ethics and disseminationMultisite ethical approval for the study has been granted by The Royal Children’s Hospital, Melbourne, Australia (Trial Reference No. 34222), and by each participating site. The trial is currently recruiting in eight centres in Victoria and New South Wales, Australia, with one previous site no longer recruiting. The trial results will be published in a peer-reviewed journal and will be presented at national and international conferences.Trial registration numberAustralian and New Zealand Clinical Trials Registry (ANZCTR): ACTRN12614001203640; pre-results.
The effect of magnesium supplementation on vascular calcification in chronic kidney disease—a randomised clinical trial (MAGiCAL-CKD): essential study design and rationale
Authors: Bressendorff Iain , Hansen Ditte , Schou Morten , Kragelund Charlotte , Brandi Lisbet 
Published: June 2017

IntroductionChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease and mortality, which is thought to be caused by increased propensity towards vascular calcification (VC). Magnesium (Mg) inhibits phosphate-induced VC in vitro and in animal models and serum Mg is inversely associated with cardiovascular mortality in predialysis CKD and in end-stage renal disease. This paper will describe the design and rationale of a randomised double-blinded placebo-controlled multicentre clinical trial, which will investigate whether oral Mg supplementation can prevent the progression of coronary artery calcification (CAC) in subjects with predialysis CKD.Methods and analysisWe will randomise 250 subjects with estimated glomerular filtration rate of 15 to 45 mL/min/1.73 m2to 12 months treatment with either slow-release Mg hydroxide 30 mmol/day or matching placebo in a 1:1 ratio. The primary end point is change in CAC score as measured by CT at baseline and after 12 months treatment. Secondary end points include change in pulse wave velocity, bone mineral density, measures of mineral metabolism and clinical end points related to cardiovascular and renal events.Ethics and disseminationThis trial has been approved by the local biomedical research ethics committees and data protection agencies and will be performed in accordance with the latest revision of the Helsinki Declaration. The trial will examine for the first time the effect of increasing the uptake of a putative VC inhibitor (ie, Mg) on progression of CAC in subjects with predialysis CKD.Trial registration numberNCT02542319, pre-results.
Facilitators and barriers to participation of private sector health facilities in government-led schemes for maternity services in India: a qualitative study
Authors: Yadav Vikas , Kumar Somesh , Balasubramaniam Sudharsanam , Srivastava Ashish , Pallipamula Suranjeen , Memon Parvez , Singh Dinesh , Bhargava Saurabh , Sunil Greeshma Ann , Sood Bulbul 
Published: June 2017

ObjectiveDespite provision of accreditation of private sector health providers in government-led schemes for maternity services in India, their participation has been low. This has led to an underutilisation of their presence, resources and expertise for providing quality maternal and newborn health services. This study explores the perception of various stakeholders on expectations, benefits, barriers and facilitators to private sector participation in government-led schemes—specifically Janani Suraksha Yojana (JSY)—for maternity service delivery.DesignNarrative-based qualitative study. Face-to-face in-depth interviews were conducted with study participants. The interviews were transcribed, translated and analysed using a reflexive and inductive approach to allow codes, categories and themes to emerge from within the data.SettingPrivate obstetricians, government health officials and FOGSI (Federation of Obstetrics and Gynaecological Societies of India) members, Jharkhand and Uttar Pradesh, India.ParticipantsEighteen purposefully selected private obstetricians from 9 cities across states of Uttar Pradesh and Jharkhand, 11 government health officials and 2 FOGSI members.ResultsThe major factors serving as barriers to participation of private practitioners in JSY—which emerged on thematic analysis—were low reimbursement amounts, delayed reimbursements, process of interaction with the government and administrative issues, previous experiences and trust deficit, lack of clarity on the accreditation process and patient-level barriers. On the other hand, factors which were facilitators to participation of private practitioners were ease of process, better communication, branding, motivation of increasing clientele as well as satisfaction of doing social service.ConclusionFactors such as financial processes and administrative delays, mistrust between the stakeholders, ambiguity in processes, lack of transparency and lack of ease in the process of empanelment of private sector are hindering effective public–private partnerships under JSY. Simplifying and strengthening the processes, communication strategies and branding can help revitalise it.
Regional study of controls on reservoir quality in the Triassic Skagerrak Formation of the Central North Sea
Authors: Akpokodje M. , Melvin A. , Churchill J. , Burns S. , Morris J. , Kape S. , Wakefield M. , Ameerali R. 
Published: June 2017

Abstract
An improved understanding of the controls on reservoir quality is key to ongoing and future exploration of the Central North Sea Triassic play. This paper presents a regional integrated study of 50 000 ft of wireline log data, 10 000 ft of core, 4431 routine core analyses measurements and 377 thin sections from 86 cored wells.
Triassic Skagerrak Formation sandstones represent thin-bedded heterogeneous reservoirs deposited in a dryland fluvial–lacustrine setting. Fluvial-channel facies are typically fine–medium grained and characterized by a low clay content, whilst lake-margin terminal splay facies are finer grained, more argillaceous and micaceous. Lacustrine intervals are mud-dominated. Primary depositional textures retain a primary control on porosity evolution through burial. Optimal reservoir quality occurs in aerially and stratigraphically restricted fluvial-channel tracts on the Drake, Greater Marnock, Puffin and Gannet terraces, and the J-Ridge area. These primary textural and compositional controls are overprinted by mechanical compaction, the development of early overpressure and diagenesis. Anomalously high porosities are retained at depth in fluvial sandstones that have a low degree of compaction and cementation, including chlorite. Forward modelling of reservoir quality using Touchstone™ software has been validated using well UK 30/8-3 where reservoir depths are >16 000 ft TVDSS (true vertical depth subsea).
Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma
Authors: Rivera Barbara , Di Iorio Massimo , Frankum Jessica , Nadaf Javad , Fahiminiya Somayyeh , Arcand Suzanna L. , Burk David L. , Grapton Damien , Tomiak Eva , Hastings Valerie , Hamel Nancy , Wagener Rabea , Aleynikova Olga , Giroux Sylvie , Hamdan Fadi F. , Dionne-Laporte Alexandre , Zogopoulos George , Rousseau Francois , Berghuis Albert M. , Provencher Diane , Rouleau Guy A. , Michaud Jacques L. , Mes-Masson Anne-Marie , Majewski Jacek , Bens Susanne , Siebert Reiner , Narod Steven A. , Akbari Mohammad R. , Lord Christopher J. , Tonin Patricia N. , Orthwein Alexandre , Foulkes William D. 
Published: June 2017

Abstract
RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating variant carriers have an increased risk for ovarian cancer. However, the contribution of nontruncating RAD51D variants to cancer predisposition remains uncertain. Using deep sequencing and case–control genotyping studies, we show that in French Canadians, the missense RAD51D variant c.620C&gt;T;p.S207L is highly prevalent and is associated with a significantly increased risk for ovarian high-grade serous carcinoma (HGSC; 3.8% cases vs. 0.2% controls). The frequency of the p.S207L variant did not significantly differ from that of controls in breast, endometrial, pancreas, or colorectal adenocarcinomas. Functionally, we show that this mutation impairs HR by disrupting the RAD51D–XRCC2 interaction and confers PARP inhibitor sensitivity. These results highlight the importance of a functional RAD51D–XRCC2 interaction to promote HR and prevent the development of HGSC. This study identifies c.620C&gt;T;p.S207L as the first bona fide pathogenic RAD51D missense cancer susceptibility allele and supports the use of targeted PARP-inhibitor therapies in ovarian cancer patients carrying deleterious missense RAD51D variants. Cancer Res; 77(16); 4517–29. ©2017 AACR.