bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Highly Efficient Catalysis of Retro‐Claisen Reactions: From a Quinone Derivative to Functionalized Imidazolium Salts.
Authors: Visbal Renso , Laguna Antonio , Gimeno M. Concepcion 
Published: July 2016

AbstractImidazolium‐4‐carboxylate salts are prepared for the first time via a retro‐Claisen reaction of quinone‐fused imidazolium salts.
ChemInform Abstract: Iron‐Catalyzed Regioselective Alkoxycarbonylation of Imidazoheterocycles with Carbazates.
Authors: Gao Yongyuan , Lu Weiye , Liu Ping , Sun Peipei 
Published: July 2016

AbstractThis is presented in continuation of studies on selective direct C—H functionalization of electron‐rich aryl rings or heterocyclic compounds.
ChemInform Abstract: Copper‐Catalyzed Intramolecular Oxidative Amination of Unactivated Internal Alkenes.
Authors: Xiong Peng , Xu Fan , Qian Xiang‐Yang , Yohannes Yared , Song Jinshuai , Lu Xin , Xu Hai‐Chao 
Published: July 2016

AbstractA broad spectrum of allylic carbamates and analogous allylic ureas can be successfully cyclized in the presence of the copper catalyst without any additional ligand.
ChemInform Abstract: Catalyst‐Free and Environment Friendly Synthesis of 2‐Aryl‐3‐substituted‐4‐thiazolidinones in Water.
Authors: Thakare Manoj P. , Shaikh Rahimullah , Tayade Dipak 
Published: July 2016

AbstractThe title compounds are prepared via three‐component one‐pot reaction of aryl aldehydes, amines, and thioglycolic acid in good to excellent yields.
ChemInform Abstract: Synthesis, Dissociation Constants, and Antimicrobial Activity of Novel 2,3‐Disubstituted‐1,3‐thiazolidin‐4‐one Derivatives.
Authors: Popiolek Lukasz , Stefanska Joanna , Kielczykowska Malgorzata , Musik Irena , Biernasiuk Anna , Malm Anna , Wujec Monika 
Published: July 2016

AbstractThe title compounds are prepared by cyclization reaction of a variety of N‐substituted carboxylic acid hydrazides with mercaptoacetic acid.
ChemInform Abstract: A Formal Intermolecular Iodolactonization Reaction Based on a Radical‐Ionic Sequence.
Authors: Leon‐Rayo David F. , Morales‐Chamorro Maricela , Cordero‐Vargas Alejandro 
Published: July 2016

AbstractBased on the title reaction, structurally diverse iodo lactones are obtained by the reaction of allylic alcohols and α‐iodo carboxylic acid.
ChemInform Abstract: Exploiting Distal Reactivity of Coumarins: A Rhodium‐Catalyzed Vinylogous Asymmetric Ring‐Opening Reaction.
Authors: Loh Charles C. J. , Schmid Matthias , Peters Brendan , Fang Xiang , Lautens Mark 
Published: July 2016

AbstractAn unprecedented example of vinylogous reactivity exemplified by the rhodium‐catalyzed asymmetric ring‐opening reaction of oxabicycles leading to the incorporation of the biologically useful coumarin motif into the hydronaphthalene scaffold is presented.
ChemInform Abstract: Harnessing the Electrophilicity of Keteniminium Ions: A Simple and Straightforward Entry to Tetrahydropyridines and Piperidines from Ynamides.
Authors: Lecomte Morgan , Evano Gwilherm 
Published: July 2016

AbstractThe title compounds are prepared by a formal intramolecular hydroalkylation of readily available substituted ynamides which generate highly reactive activated keteniminium ions upon simple activation under acidic conditions.
ChemInform Abstract: Reusable Ce‐V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media.
Authors: Maddila Suresh , Maddila Surya N. , Jonnalagadda Sreekantha B. , Lavanya Palakondu 
Published: July 2016

AbstractAn efficient and environmentally benign three‐component one‐pot procedure for the preparation of multisubstituted pyridines using a novel effective heterogeneous catalyst is presented.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of 4‐Bromo‐1,2‐dihydroisoquinolines: Access to Bromonium Ylides by the Intramolecular Reaction of a Benzyl Bromide and an α‐Imino Carbene.
Authors: He Jun , Shi Yinping , Cheng Wanli , Man Zengming , Yang Dongdong , Li Chuan‐Ying 
Published: July 2016

AbstractHighly functionalized isoquinolines are prepared from readily available aryl‐sulfonyl‐triazoles.
ChemInform Abstract: Annulation Reaction of 3‐Acylmethylidene Oxindoles with Huisgen Zwitterions and Its Applications in the Syntheses of Pyrrolo[4,3,2‐de]quinolinones and Marine Alkaloids Ammosamides.
Authors: Yang Changjiang , Chen Xiangyu , Tang Tong , He Zhengjie 
Published: July 2016

AbstractThe method offers access to a broad range of variously functionalized pyrrolo[4,3,2‐de]quinolinones following a two‐step reaction sequence which may be performed in an efficient scalable one‐pot manner.
ChemInform Abstract: Synthesis and Orthogonal Functionalization of Oxazolo[5′,4′:4,5]pyrano[2,3‐b]pyridine by Intra‐ and Intermolecular Pd‐Catalyzed Direct C—H Bond Heteroarylation.
Authors: Theveau Laure , Schneider Cedric , Querolle Olivier , Meerpoel Lieven , Levacher Vincent , Hoarau Christophe 
Published: July 2016

AbstractThe chlorine atom at the pyridine moiety is preserved during both Pd‐catalyzed C—H functionalization reactions, allowing for late stage functionalizations at this position.
ChemInform Abstract: 4‐Hydroxy‐1‐phenylquinolin‐2(1H)‐one in One‐Pot Synthesis of Pyrimidoquinolines and Related Compounds under Microwave Irradiation and Conventional Conditions.
Authors: Mourad Aboul‐Fetouh E. , Amer Amer A. , El‐Shaieb Kamal M. , Ali Ali M. , Aly Ashraf A. 
Published: July 2016

AbstractThe title compound is utilized in Biginelli condensation reactions with aryl aldehydes and urea, or thiourea, triazole, and benzimidazole.
ChemInform Abstract: Copper‐Catalyzed Radical Reactions of 2‐Azido‐N‐arylacrylamides with 1‐(Trifluoromethyl)‐1,2‐benziodoxole and 1‐Azidyl‐1,2‐benziodoxole.
Authors: Yang Tonghao , Zhu Haizhen , Yu Wei 
Published: July 2016

Abstract2‐Azido‐N‐arylacrylamides react with trifluoromethyl radicals and azidyl radicals, respectively, by using Togni′s reagent and Zhdankin′s reagent as radical sources via a tandem addition/cyclization process catalyzed by CuI.
ChemInform Abstract: Synthesis and Applications of Silyl 2‐Methylprop‐2‐ene‐1‐sulfinates in Preparative Silylation and GC‐Derivatization Reactions of Polyols and Carbohydrates.
Authors: Markovic Dean , Tchawou Wandji Augustin , Novosjolova Irina , Laclef Sylvain , Stepanovs Dmitrijs , Turks Maris , Vogel Pierre 
Published: July 2016

AbstractTrimethylsilyl, triethylsilyl, tert‐butyldimethylsilyl, and triisopropylsilyl 2‐methylprop‐2‐ene‐1‐sulfinates are prepared by Cu‐catalyzed sila‐ene reactions of methallylsilanes with SO2.
ChemInform Abstract: Isolation, Synthesis, and Biological Activity of Tomentosenol A from the Leaves of Rhodomyrtus tomentosa.
Authors: Liu Hong‐Xin , Zhang Wei‐Min , Xu Zhi‐Fang , Chen Yu‐Chan , Tan Hai‐Bo , Qiu Sheng‐Xiang 
Published: July 2016

AbstractThe isolation and the first total synthesis of tomentosenol A (I) is presented.
ChemInform Abstract: Total Syntheses of the Tetracyclic Cyclopiane Diterpenes Conidiogenone, Conidiogenol, and Conidiogenone B.
Authors: Hou Si‐Hua , Tu Yong‐Qiang , Wang Shuang‐Hu , Xi Chao‐Chao , Zhang Fu‐Min , Wang Shao‐Hua , Li Yan‐Tao , Liu Lin 
Published: July 2016

AbstractThe total synthesis of the cyclopiane class tetracyclic diterpene conidiogenone B (IV) is accomplished in 25 steps involving the highly efficient construction of both ring C and the quaternary center shared by rings A and C by one‐step regioselective and diastereoselective cycloenlargement in form of a semipinacol‐type rearrangement as key feature.
ChemInform Abstract: Purely Chemical Approach for Preparation of D‐α‐Amino Acids via (S)‐to‐(R)‐Interconversion of Unprotected Tailor‐Made α‐Amino Acids.
Authors: Nian Yong , Wang Jiang , Zhou Shengbin , Dai Wenhao , Wang Shuni , Moriwaki Hiroki , Kawashima Aki , Soloshonok Vadim A. , Liu Hong 
Published: July 2016

AbstractA purely chemical approach for preparation of (R)‐α‐amino acids of growing biomedical and pharmaceutical importance is developed.
ChemInform Abstract: Two New Glycosidal Metabolites of Endophytic Fungus Penicillium sp. (NO.4) from Tapiscia sinensis
Authors: Wan Qiao , Feng Ziwei , Li Xueshuang , Lv Mengmeng , Guo Zhiyong , Deng Zhangshuang , Zou Kun 
Published: July 2016

Abstractisolation, structure elucidation, cytotoxic as well as antimicrobial activities
ChemInform Abstract: Morphological Evolution of Prussian Yellow Fe[Fe(CN)6] Colloidal Nanospheres.
Authors: Gu Jianmin , Fu Shaoyan , Jin Cuihong , Liu Xin , Gao Yahui , Wu Jingxiao , Bian Zhenpan , Tian Hua , Wang Lin , Gao Faming 
Published: July 2016

AbstractFe[Fe(CN)6] nanostructures with controllable morphologies are hydrothermally synthesized from aqueous mixtures of K3[Fe(CN)6, Na2HPO4 or NaH2PO4, and cetyltrimethylammonium bromide (autoclave, 140 °C, 48 h).
ChemInform Abstract: Diastereo‐ and Enantioselective Synthesis of Polyfunctionalized Diquinanes, Hydrindanes, and Decalins Bearing a Hydroxyl Group at the Ring Junction
Authors: Heinrich Clement F. , Peter Clovis , Miesch Laurence , Geoffroy Philippe , Miesch Michel 
Published: July 2016

AbstractReview: [30 refs.
ChemInform Abstract: Research Advances in Deriving Renewable Energy from Biomass in Wastewater Treatment Plants
Authors: Zhang Yuan‐kai , Liu Xiu‐hong , Liu Xiao‐wei , Zha Yi‐fei , Xu Xiang‐long , Ren Zheng‐guang , Jiang Hang‐cheng , Wang Hong‐chen 
Published: July 2016

AbstractReview: 161 refs.
ChemInform Abstract: First‐Principles Studies of Multiferroic and Magnetoelectric Materials
Authors: Fang Yue‐Wen , Ding Hang‐Chen , Tong Wen‐Yi , Zhu Wan‐Jiao , Shen Xin , Gong Shi‐Jing , Wan Xian‐Gang , Duan Chun‐Gang 
Published: July 2016

AbstractReview: 293 refs.
Polychromatic flow cytometry is more sensitive than microscopy in detecting small monoclonal plasma cell populations
Authors: Tran Daniel N. , Smith Sandy A. B. C. , Brown David A. , Parker Andrew J. C. , Joseph Joanne E. , Armstrong Nicola , Sewell William A. 
Published: July 2016

BackgroundThere is an emerging role for flow cytometry (FC) in the assessment of small populations of plasma cells (PC). However, FC's utility has been questioned due to consistent underestimation of the percentage of PC compared to microscopy.MethodsA retrospective study was performed on bone marrow samples analysed by 8‐colour FC. Plasma cell populations were classified as polyclonal or monoclonal based on FC analysis. FC findings were compared with microscopy of aspirates, histology and immunohistochemistry of trephine biopsies, and immunofixation (IFX) of serum and/or urine.ResultsFC underestimated PC compared to aspirate and trephine microscopy. The 10% diagnostic cutoff for MM on aspirate microscopy corresponded to a 3.5% cutoff on FC. Abnormal plasma cell morphology by aspirate microscopy and clonality by FC correlated in 229 of 294 cases (78%). However, in 50 cases, FC demonstrated a monoclonal population but microscopy reported no abnormality. In 15 cases, abnormalities were reported by microscopy but not by FC. Clonality assessment by trephine microscopy and FC agreed in 251/280 cases (90%), but all 29 discordant cases were monoclonal by FC and not monoclonal by microscopy. These cases had fewer PC and proportionally more polyclonal PC, and when IFX detected a paraprotein, it had the same light chain as in the PC determined by FC.ConclusionsFC was more sensitive in detecting monoclonal populations that were small or accompanied by polyclonal PC. This study supports the inclusion of FC in the evaluation of PC, especially in the assessment of small populations. © 2016 International Clinical Cytometry Society
Prognostic implications of mitral regurgitation in patients after cardiac resynchronization therapy
Authors: Cipriani Manlio , Lunati Maurizio , Landolina Maurizio , Proclemer Alessandro , Boriani Giuseppe , Ricci Renato P. , Rordorf Roberto , Matassini Maria Vittoria , Padeletti Luigi , Iacopino Saverio , Molon Giulio , Perego Giovanni B. , Gasparini Maurizio ,   on behalf of the Italian ClinicalService Project Investigators
Published: July 2016

AbstractAimMitral regurgitation (MR) is a common finding in patients with heart failure with debatable effects on prognosis. Reduction in MR is one of the mechanisms by which cardiac resynchronization therapy (CRT) exerts its beneficial effects. We investigated the prognostic impact of baseline MR and MR persistence after CRT on outcomes of treated patients.Methods and resultsWe prospectively followed 1122 CRT patients (66.4 ± 10.3 years, 78% male) who were stratified according to baseline MR severity as having MR− (degree 0–1; n = 508, 45%) or MR+ (degrees 2–3–4; n = 614, 55%). In 916 patients (82%) with MR severity data available at 1‐year follow‐up, the annual mortality rate was 3.4 and 6.0 per patient‐year in the MR− and MR+ group, respectively, with a 1‐year incidence rate ratio (IRR) of 1.76 (P < 0.001). Similar results were observed for cardiovascular mortality (1‐year IRR 1.72, P = 0.002). When considering survival according to MR severity after CRT, all‐cause and cardiovascular mortality were lower in the improved than in the worsened group (1‐year IRR 1.87 and 2.33, respectively; both P < 0.001). Regression analysis showed that absence of MR improvement at follow‐up was a significant independent predictor of both all‐cause and cardiovascular mortality.ConclusionsBaseline significant MR and absence of MR improvement after CRT are strongly predictive of less favourable long‐term survival.
Supported IrxRu1–xO2 Anode Catalysts for PEM‐Water Electrolysis
Authors: Baumann N. , Cremers C. , Pinkwart K. , Tübke J. 
Published: July 2016

AbstractSince PEM‐water electrolysis (PEMWE) produces very pure H2, reacts fast and well to dynamic load conditions and is technologically simple, it could play a large role in a future hydrogen economy. One way to alleviate the drawback of expensive noble metal catalysts is to disperse the active component on a support. Tungsten oxide and tungsten carbide were investigated here comparing different synthesis routes. Adam's fusion and hydrolysis route with the addition of support during different stages of the synthesis and mechanical mixing of catalyst and support were investigated and compared. Rotating Disk Electrode (RDE) measurements show high currents for mechanically mixed samples and samples obtained via hydrolysis with a WO3 precursor. Single cell tests confirm catalyst activity and stability. Further studies are needed to completely understand catalyst behavior, especially fast activity loss during RDE.
Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease
Authors: Ballarini Tommaso , Iaccarino Leonardo , Magnani Giuseppe , Ayakta Nagehan , Miller Bruce L. , Jagust William J. , Gorno‐Tempini Maria Luisa , Rabinovici Gil D. , Perani Daniela 
Published: July 2016

AbstractNeuropsychiatric symptoms (NPSs) often occur in early‐age‐of‐onset Alzheimer's disease (EOAD) and cluster into sub‐syndromes (SSy). The aim of this study was to investigate the association between 18F‐FDG‐PET regional and connectivity‐based brain metabolic dysfunctions and neuropsychiatric SSy. NPSs were assessed in 27 EOAD using the Neuropsychiatric Inventory and further clustered into four SSy (apathetic, hyperactivity, affective, and psychotic SSy). Eighty‐five percent of EOAD showed at least one NPS. Voxel‐wise correlations between SSy scores and brain glucose metabolism (assessed with 18F‐FDG positron emission tomography) were studied. Interregional correlation analysis was used to explore metabolic connectivity in the salience (aSN) and default mode networks (DMN) in a larger sample of EOAD (N = 51) and Healthy Controls (N = 57). The apathetic, hyperactivity, and affective SSy were highly prevalent (>60%) as compared to the psychotic SSy (33%). The hyperactivity SSy scores were associated with increase of glucose metabolism in frontal and limbic structures, implicated in behavioral control. A comparable positive correlation with part of the same network was found for the affective SSy scores. On the other hand, the apathetic SSy scores were negatively correlated with metabolism in the bilateral orbitofrontal and dorsolateral frontal cortex known to be involved in motivation and decision‐making processes. Consistent with these SSy regional correlations with brain metabolic dysfunction, the connectivity analysis showed increases in the aSN and decreases in the DMN. Behavioral abnormalities in EOAD are associated with specific dysfunctional changes in brain metabolic activity, in particular in the aSN that seems to play a crucial role in NPSs in EOAD. Hum Brain Mapp 37:4234–4247, 2016. © 2016 Wiley Periodicals, Inc.
Functional topography of the right inferior parietal lobule structured by anatomical connectivity profiles
Authors: Wang Jiaojian , Zhang Jinfeng , Rong Menglin , Wei Xuehu , Zheng Dingchen , Fox Peter T. , Eickhoff Simon B. , Jiang Tianzi 
Published: July 2016

AbstractThe nature of the relationship between structure and function is a fundamental question in neuroscience, especially at the macroscopic neuroimaging level. Although mounting studies have revealed that functional connectivity reflects structural connectivity, whether similar structural and functional connectivity patterns can reveal corresponding similarities in the structural and functional topography remains an open problem. In our current study, we used the right inferior parietal lobule (RIPL), which has been demonstrated to have similar anatomical and functional connectivity patterns at the subregional level, to directly test the hypothesis that similar structural and functional connectivity patterns can inform the corresponding topography of this area. In addition, since the association between the RIPL regions and particular functions and networks is still largely unknown, post‐hoc functional characterizations and connectivity analyses were performed to identify the main functions and cortical networks in which each subregion participated. Anatomical and functional connectivity‐based parcellations of the RIPL have consistently identified five subregions. Our functional characterization using meta‐analysis‐based behavioral and connectivity analyses revealed that the two anterior subregions (Cl1 and Cl2) primarily participate in interoception and execution, respectively; whereas the posterior subregion (Cl3) in the SMG primarily participates in attention and action inhibition. The two posterior subregions (Cl4, Cl5) in the AG were primarily involved in social cognition and spatial cognition, respectively. These results indicated that similar anatomical and functional connectivity patterns of the RIPL are reflected in corresponding structural and functional topographies. The identified cortical connectivity and functional characterization of each subregion may facilitate RIPL‐related clinical research. Hum Brain Mapp 37:4316–4332, 2016. © 2016 Wiley Periodicals, Inc.
Observation of Confinement‐Induced Self‐Poling Effects in Ferroelectric Polymer Nanowires Grown by Template Wetting
Authors: Whiter Richard A. , Calahorra Yonatan , Ou Canlin , Kar‐Narayan Sohini 
Published: July 2016

Ferroelectric polymer nanowires grown using a template‐wetting method are shown to achieve an orientated “self‐poled” structure resulting from the confined growth process. Self‐poling is highly desirable as it negates the need for high electric fields, mechanical stretching, and/or high temperatures typically associated with poling treatments in ferroelectric polymers, as required for piezoelectric and/or pyroelectric applications. Here, differential scanning calorimetry, infrared spectroscopy, and dielectric permittivity measurements have been presented on as‐fabricated template‐grown polyvinylidene fluoride‐trifluoroethylene nanowires, and quantitatively compared with spin‐cast films of the same composition that have been electrically poled, both before and after subsequent depoling temperature treatment. The measurements reveal remarkably similar trends between the physical properties of the as‐grown nanowires and the electrically poled film samples, providing insight into the material structure of the “self‐poled” nanowires. In addition, piezoresponse force microscopy data are presented that allow for unambiguous identification of self‐poling in ferroelectric polymer nanostructures. Our results indicate the suitability of the template‐wetting approach in fabricating nanowires that can be used directly for piezoelectric/pyroelectric applications, without the need for post‐deposition poling/processing.image
How to do comparative dynamics on the back of an envelope for open‐loop Nash equilibria in differential game theory
Authors: Caputo Michael R. , Ling Chen 
Published: July 2016

SummaryThe primal‐dual comparative statics method of Samuelson (1965) and Silberberg (1974) is extended to cover the class of non‐autonomous, finite horizon differential games in which a locally differentiable open‐loop Nash equilibrium exists. In doing so, not only is a one‐line proof of an envelope theorem provided but also the heretofore unknown intrinrsic comparative dynamics of open‐loop Nash equilibria are uncovered. The intrinsic comparative dynamics are shown to be contained in a symmetric and negative semidefinite matrix that is subject to constraint. The results are applied to a canonical differential game in capital theory, and the resulting comparative dynamics are given an economic interpretation. Copyright © 2016 John Wiley & Sons, Ltd.
Zoledronate as effective treatment for minimal trauma fractures in a child with STAT3 deficiency and osteonecrosis of the hip
Authors: Staines Boone Aidé Tamara , Alcántara‐Montiel Julio César , Sánchez‐Sánchez Luz María , Arce‐Cano Marina , García‐Campos Jorge , Lugo Reyes Saúl Oswaldo 
Published: July 2016

AbstractSignal transducer and activator of transcription 3 (STAT3) deficiency is a primary immunodeficiency characterized by eczema, complicated recurrent infections, elevated serum immunoglobulin E (IgE), osteopenia, and minimal trauma fractures. Zoledronic acid (ZA) is a long‐acting bisphosphonate that has been successfully used in children with secondary osteoporosis and osteogenesis imperfecta. We describe the case of a 7‐year‐old male with STAT3 deficiency and minimal trauma fractures, who also developed osteonecrosis of the hip. He responded well to intravenous ZA every 6 months for 18 months. Three years later, he walks independently and unaided, and has not suffered any other fractures. Although more studies are needed, ZA might help reduce minimal trauma fractures in patients with STAT3 deficiency.
Pro‐insecticidal approach towards increasing in planta activity
Authors: Creemer Lawrence C , Giampietro Natalie C , Lambert William , Yap Maurice C , deBoer Gerrit J , Adelfinskaya Yelena , Castetter Scott , Wessels Frank J 
Published: July 2016

AbstractBACKGROUNDThe adrenergic mode of action was investigated for the development of potential new insecticides. Clonidine‐related analogs were tested against Myzus persicae (Sulzer) and Bemisia tabaci (Gennadius). Clonidine analogs lack translation owing to a possible vacuole‐trapping mechanism. Physical property modulation via a prodrug approach was attempted to overcome this mechanism.RESULTSClonidine showed insecticidal activity against M. persicae and B. tabaci. A prodrug of a known open‐chain analog of clonidine was developed. While the prodrug had decreased pKa and increased lipophilicity and displayed good activity against M. persicae B. tabaci, the activity did not translate to cotton. Metabolic studies showed that the prodrug was quickly metabolized to the parent compound, and was further metabolized to a known vacuole‐trapped oxazoline analog.CONCLUSIONSAdrenergic active compounds, such as clonidine analogs, show potential as insecticides; however, a designed prodrug approach did not overcome the lack of translation in this case. Studies confirmed that the synthesized prodrug analog metabolized in planta to the proposed vacuole‐trapped compound. One possible explanation for the failure of this approach is that the rate of metabolism and vacuole trapping is faster than translaminar flow, and therefore the released pesticide is not biologically available to the target organism. © 2016 Society of Chemical Industry