bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prática de exercício físico ou esporte dos idosos jovens e longevos e o conhecimento dos mesmos em programas públicos: Pesquisa Nacional de Saúde 2013
Authors: Biehl-Printes Clarissa , Brauner Fabiane De Oliveira , Rocha Josemara De Paula , Oliveira Gabriela , Neris Jéssika , Rauber Bruna , Bós Ângelo José 
Published: May 2017

Objective: describe and relate the practice, participation, knowledge and reason of non-participation in programs of exercise or sport offered by government programs to old-adult and the oldest old. Methods: secondary analysis of results of the Brazilian 2013 National Health Survey. We analyzed the frequency of responses to the questions P34 (physical exercise or sport), P47 (knowledge of a public program of physical exercise or sport), P48 (participation in these programs), P49 (reason not to participate in these programs) and P36 (physical exercise or sport that practices more often) in two age groups: old-adult (60 to 79 years) and oldest old (80 or more). The chi-square statistical test was used to verify the distribution considering p<0.05. Results: The study had 9,679 young elderly and 1,498 oldest old. Most Brazilians older-adult 78,9% did not exercise with significant differences between old-adult (77,3%) and oldest old (89,3%). Furthermore, 81,6% did not know the existence of public programs and those who know the vast majority did not participate, 82,6%. The most common reason for non-participation was the lack of interest (39%) and walking is the modality more attractive 58,4%.Conclusions: The study reveals a low compliance of the older-adult in physical exercise or sport practices. This study shows a necessity to publicize and increase the diversity of public programs to encourage the exercise or sport in these people. New studies into the communication mechanisms used in the public network for disclosure of these programs are encouraged.
Consumo de sustancias psicoactivas en auxiliares de enfermería
Authors: Londoño Restrepo Johanna , Álvarez Gómez Matilde Ligia 
Published: May 2017

Introducción: El consumo de drogas trae consecuencias adversas en todos los ámbitos y se considera un problema de salud pública. El objetivo fue determinar la prevalencia de consumo de sustancias psicoactivas en auxiliares de enfermería. Materiales y Métodos: Estudio descriptivo, transversal, muestra probabilística constituida por 110 auxiliares de enfermería que trabajaban en una institución de salud. La información se recolectó a través de una encuesta que contenía variables demográficas y de consumo, se aplicaron los test de CAGE y de Fagerström. Se calcularon medidas de tendencia central y de dispersión para variables cuantitativas y frecuencias absolutas y relativas para las cualitativas, se realizó análisis bivariado, que estableció la diferencia de proporciones de consumo en vida de sustancias psicoactivas por algunas variables sociodemográficas. Resultados: La mediana de edad fue de 29 años, el 81.8% eran mujeres, el 60% estaban solteras. La sustancia más consumida fue el alcohol con 62.7%, seguido por bebidas energizantes con 28.2% y tabaco 19.1%. Discusión: Igual que en otros estudios las sustancias más consumidas fueron el alcohol y el tabaco, los que más consumieron fueron los hombres. Los motivos para el consumo fueron socializar. Más de la cuarta parte consumieron bebidas energizantes para aumentar el estado de alerta. La prevalencia del consumo de alcohol en vida es menor que la reportada en población general colombiana. Conclusiones: El consumo de sustancias legales e ilegales excepto los sedantes fue menor a las reportadas en población general y semejante a otros estudios en personal de salud.Cómo citar este artículo: Londoño J, Álvarez ML. Consumo de sustancias psicoactivas en auxiliares de enfermería. Rev Cuid. 2017; 8(2): 1591-8. http://dx.doi.org/10.15649/cuidarte.v8i2.378
The Multicultural Café: Enhancing Authentic Interaction for Adult English Language Learners Through Service Learning
Authors: Riley Tracy , Douglas Scott Roy 
Published: May 2017

While service learning platforms hold great potential for adult learners of English as an additional language (EAL), there has been little research to date related to the impact of these programs on adult newcomers’ linguistic and social development. The Multicultural Café was a food service learning platform for adult EAL learners operated over a 7-month period at a regional college in the British Columbia interior. The café was developed to provide adult immigrant learners of EAL with an opportunity to authentically engage in using English to provide a valued service to the local community. The current study was conducted to explore the impact of the service learning experience from the perspective of the participants. Using a qualitative case study research design, data were gathered from participants (n = 10) through a questionnaire, semistructured interviews, and a focus group. Data were transcribed, coded, and collected into emerging themes. Opportunities for authentic interactions with customers and with other volunteer coworkers emerged as two of the primary outcomes of the service learning experience. Incorporating the service learning opportunity of the Multicultural Café into the participants’ English language learning experiences appeared to enhance their interactions within the college community. Les cadres d’apprentissage par le service communautaire sont très prome eurs pour les apprenants adultes d’anglais langue additionnel (ALA); pourtant, peu de recherche a porté sur l’impact de ces programmes sur le développement linguistique et social des nouveaux arrivants d’âge adulte. Le Café Multiculturel a constitué, pendant une période de 7 mois, un milieu d’apprentissage par le service pour des apprenants adultes d’ALA dans un collège régional de l’intérieur de la Colombie-Britannique. Le café a été développé pour fournir aux immigrants adultes apprenant l’ALA l’occasion de communiquer authentiquement en anglais tout en offrant un service important à la communauté locale. La présente étude a porté sur l’impact de l’expérience d’apprentissage par le service selon la perspective des participants. Employant un plan de recherche qualitative visant une étude de cas, nous avons recueilli des données de participants (n = 10) par le biais d’un questionnaire, d’entrevues semi-structurées et d’un groupe de discussion. Les données ont été transcrites, codées et rassemblées selon des thèmes qui s’y dégageaient. Deux des résultats principaux de l’expérience de l’apprentissage par le service consistaient en les occasions d’interactions authentiques avec les clients et avec les autres collègues bénévoles. L’intégration, dans le parcours pédagogique des apprenants d’anglais, de l’expérience de l’apprentissage par le service au Café Multiculturel semble avoir mis en valeur leurs interactions au sein de la communauté du collège.
Prévalence des principales bactéries responsables de mammites subcliniques des vaches laitières au nord-est de l’Algérie
Authors: Boufaida Asnoune Z. , Butel M. J. , Ouzrout R. 
Published: May 2017

Des analyses bactériologiques de 235 prélèvements de lait de vaches laitières atteintes de mammites subcliniques dépistées par le California mastitis test, provenant de dix exploitations du nord-est de l’Algérie, ont été réalisées sur une période de deux ans (2008-10). L’isolement bactérien a concerné 89 p. 100 des échantillons. Parmi les germes isolés, les coques à Gram positif ont été les plus fréquents, notamment des staphylocoques à coagulase négative (43 p. 100) et Staphylococcus aureus (30 p. 100). Escherichia coli a été isolé dans 14 p. 100 des prélèvements. Les autres germes isolés ont été Streptococcus uberis (4 p. 100), Streptococcus agalactiae (3 p. 100), Streptococcus dysgalactiae (3 p. 100), et Klebsiella sp. plus rarement (2 p. 100).
RESEARCH IN ONLINE SPACE: THE USE OF SOCIAL MEDIA FOR RESEARCH SETTING
Authors: Nurdin Nurdin 
Published: May 2017

Web 2.0 technology has supported the arrival of various social and collaborative applications. Those applications, which is known as social media, provide an opportunity for users to express their opinions and share their knowledge and thoughts with others in online space. This provides opportunities for reseachers to extend their research setting and generate data within a broader environement. As a result, researchers have increasingly turned to social media sites to practice their research to expand the scope and improve the analytic power of their studies. Yet there is still relatively little direction on and much confusion about how to gather data using qualitative and quantitative approaches on social media sites. Through an exstensive literature review from Information Technology and Information System journals, this studi proposes new data gathering strategies within a broader environment of social media sites. This study contributes to understanding of using social media for new research settings. The limitation and future research of this study is addressed.
CX-4945, a Selective Inhibitor of Casein Kinase 2, Synergizes with B Cell Receptor Signaling Inhibitors in Inducing Diffuse Large B Cell Lymphoma Cell Death
Authors: Mandato Elisa , Nunes Sara Canovas , Zaffino Fortunato , Casellato Alessandro , Macaccaro Paolo , Tubi Laura Quotti , Visentin Andrea , Trentin Livio , Semenzato Gianpietro , Piazza Francesco 
Published: May 2017

Background:
Approximately one third of Diffuse Large B cell Lymphomas (DLBCL)
are refractory or relapse. Novel therapeutic approaches under scrutiny include inhibitors of B-cell
receptor (BCR) signaling. Protein kinase CK2 propels survival, proliferation and stress response in
solid and hematologic malignancies and promotes a “non-oncogene addiction” phenotype. Whether
this kinase regulates BCR signaling, being a suitable pharmacological target in DLBCL, is unknown.

Objective:
The objective was to establish if CK2 controls DLBCL cell survival and the BCR signaling,
to check if the combination of CK2 inhibitor CX-4945 and BCR blockers Ibrutinib and Fostamatinib
is more effectively cytotoxic for DLBCL cells than the single agents and to survey the
changes in signaling molecules downstream BCR upon CK2 inhibition.

Method:
A panel of GC and ABC DLBCL cells was treated with CX-4945 and Fostamatinib or
Ibrutinib. BCR signaling was assayed by intracellular Ca++ measurement and looking at the phosphorylation
of signaling molecules. The effects on cell survival were assessed by flow cytometry,
western blot and MTT assays.

Results:
CK2 inhibition with CX-4945 causes DLBCL cell death. CX-4945 impaired AKT phosphorylation
and intracellular Ca++ mobilization upon BCR engagement. The CK2 inhibitor acted
synergistically with either the SYK inhibitor Fostamatinib or the BTK inhibitor Ibrutinib in inducing
DLBCL cell death. CX-4945 was equally effective in GC and ABC DLBCL subtypes as well as in
“double hit” DLBCL cell lines.

Conclusion:
These findings suggest a role for CK2 downstream of the BCR in controlling survival
pathways crucial for cell growth of different DLBCL subtypes. Also, the use of CX-4945 in combination
with BCR signaling blockers could represent a novel rational therapeutic approach in the
DLBCL.
Structural Behavior of Strengthened RC Beams in Shear using CFRP Strips
Authors: Ibrahim Amer M. , Mansor Ahmed Abdullah , Hameed Muthafer 
Published: May 2017

Carbon fiber reinforced polymers (CFRP) were widely used in strengthening of reinforced concrete members in the last few years. Experimental and theoretical investigations were carried out to find the behavior of reinforced concrete beams strengthened in shear by CFRP strips. Six beams measured of 200x300x2000mm were investigated. The variables investigated in this work are orientation (vertical and inclined) and the spacing between CFRP strips.It was found that the strengthening by CFRP strips increased the crack, yield and ultimate load by 10%, 71% and 77% respectively on average. Inclined CFRP strips show a better performance than vertical CFRP strips with same distances and increase the yield and ultimate load by 11% and 13% respectively on average. By covering all faces of specimen with CFRP strips, the yield and ultimate load increased by 82% and 95% respectively. Using the CFRP strips changed the failure model from shear to flexural by increasing the shear strength, so the ductility was increased by 198% on average. CFRP increased the strain in compression face of concrete and the value was greater than (0.003). For all strengthened specimens, there was no effect on CFRP strips.
Studies of preparation, characterization, and solubility of mefenamic acid-nicotinamide co-crystal synthesized by using melt crystallization method
Authors: Purwantoro Dwi Utami , Nugrahani Ilma , Surantaatmadja Slamet Ibrahim 
Published: May 2017

Objective : The objective of this study is to develop the formation mefenamic acid (MFA) – nicotinamide (NCT) co-crystal by using melt crystallization method and investigate its solubility.Method : Co-crystal was prepared by using melt crystallization method of MFA-NCT (1:2) at (220±3) ° C. The initial co-crystal formation was performed by powder x-ray diffraction (PXRD). The thin layer chromatography (TLC) method was done to confirm the chemical stability of MFA and NCT due to synthesized process. The melt crystallization of MFA-NCT (1:2) was characterized by DSC/TG, Infrared spectrophotometry, and scanning electron microscopy. The solubility of the melt crystallization of MFA-NCT (1:2) was evaluated by incubated the samples in water at 25 °C and shaken for 24 h. The solubility of MFA was measured by UV-Vis spectrophotometer.Result : Characterizations of a co-crystal MFA-NCT (1:2) including PXRD, FTIR, DSC and SEM have indicated the formation of new solid crystal phase that differ from MFA, NCT and its physical mixture. The chromatogram of the TLC study exhibited two spot that corresponds to MFA and NCT. The solubility of the melt crystallization of MFA-NCT (1:2) was 57.97 % higher than MFA solubility.Conclusion : These results suggest that MFA-NCT co-crystal can be synthesized by using melt crystallization method without decomposition of its component and provides an opportunity for the development of MFA solid form.Keywords: co-crystal, mefenamic acid, nicotinamide, melt crystallization, solubility
FORMULATION AND EVALUATION OF NIOSOMAL SUSPENSION OF CEFIXIME
Authors: Nair Sreeja C , Kumar Bhama Santosh , Krishna Rakhi , Ps Lakshmi , Vasudev Deepa T 
Published: May 2017

Objectives : The present study was aimed to overcome the problems associated with the drug such as bioavailability, to reduce the dosage regimen, half life and to determine the appropriateness of niosomal formulation as a drug carrier.Methods: The niosomal suspension was prepared by thin film technique, by varying ratios of span 60 and cholesterol and varying the concentration of span 60. The prepared four formulations were evaluated for various parameters.Results: The optimized formulation had a vesicular size of 250-400nm .Varying the concentration of span 60 ,the entrapment efficiency demonstrated that it had a considerable task.The highest entrapment efficiency was 95.3%. The kinetics study confirmed that the liberation of drug from the niosomal suspension is in a restricted manner. The statistical optimization showed that NS2 is the optimized formulation. The gastrointestinal enzymes showed no significant change in the release of drug from the formulation. The Zone of Inhibition showed that Optimized formulation has better activity than the marketed formulation. The MIC was found to be 0.05mg , hence can be used as a efficient carrier for delivery of Cefixime.Conclusion: The present study concludes that the prepared Niosomal suspension is a convenient and efficiency carrier for the delivery of antibacterial drug. Besides this, it provided controlled delivery of drug.Keywords: Niosomes, Cholesterol, Thin film technique, Vesicular size, Controlled drug delivery.
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOSULPIRIDE BY USING NATURAL POLYMER
Authors: Shanmugam S 
Published: May 2017

Objective: The objective of the present study was to develop sustained release matrix tablets of levosulpiride by using natural polymers.Method: The tablets were prepared with different ratios of Chitosan, Xanthan gum and Guar gum by wet granulation technique. The solubility study of the levosulpiride was conducted to select a suitable dissolution media for in vitro drug release studies.Results: Fourier transform infrared (FTIR) study revealed no considerable changes in IR peak of levosulpiride and hence no interaction between drug and the excipients. DSC thermograms showed that no drug interaction occurred during the manufacturing process. In vitro dissolution study was carried out for all the formulation and the results compared with marketed sustained release tablet. The drug release from matrix tablets was found to decrease with increase in polymer ratio of Chitosan, Xanthan gum and Guar gum.Conclusion: Formulation LF3 exhibited almost similar drug release profile in dissolution media as that of marketed tablets. From the results of dissolution data fitted to various drug release kinetic equations, it was observed that highest correlation was found for First order, Higuchi’s and Korsmeyer equation, which indicate that the drug release occurred via diffusion mechanism. Keywords: Levosulpiride, sustained release tablets, natural polymers, in vitro drug release studies
La Reforma, un nuevo paradigma de la teología
Authors: Hoffmann Martin 
Published: May 2017

A 500 años del origen del protestantismo, se plantea la pregunta: ¿Cuál es el significado de la Reforma para hoy? El autor sostiene que la importancia de la Reforma va más allá de una época histórica o de una controversia teológica de su tiempo. Más bien la Reforma es un proceso permanente, un movimiento y un cierto método del quehacer teológico. Remontándose a la teología de la cruz del apóstol Pablo, Martín Lutero, el iniciador de la Reforma, desarrolló un nuevo paradigma de la teología. Es caracterizado por tres aspectos: La cruz como principio epistemológico, la justicia de Dios como contenido esencial del Evangelio, y una ética discursiva de los mandamientos. Este paradigma de la teología posibilita una renovación y una transformación continua de las iglesias y de la teología enfrente de los desafíos contemporáneos como las crisis de la ecología, de la economía, de la justicia social y el aumento de violencia y guerras. La actualidad de la Reforma se demuestra en su nuevo modo de pensar y de actuar, o sea en su potencial crítico a partir del Crucificado y sus perspectivas constructivas para la humanidad y la convivencia a partir de la justicia de Dios.
Queratocono: una revisión y posible situación epidemiológica en Colombia.
Authors: Mora Valencia Matilde , Bonilla Estévez Claudia , Vargas Garzón Oswaldo , Giraldo Valencia Olga Lucía 
Published: May 2017

En Colombia y en el mundo entero sabemos cómo definir el queratocono, lo diagnosticamos con una excelente propiedad, incluso muchas veces, aún sin ayuda de la topografía corneal, con una prueba de queratometría, los profesionales de la salud visual y ocular podemos observar miras no nítidas inductoras de queratocono. Es una degeneración corneal de causa idiopática. Decir que su origen es hereditario, puede ser tan falso como decir que su origen es metabólico. ¿Que sabemos a ciencia cierta? mucho y nada, pero la única realidad es que mientras en otros países su incidencia y prevalencia es conocida, en Colombia no tenemos datos registrados oficialmente. El registro es subclínico, pues aunque existe entre la clasificación internacional de las enfermedades, versión 10, como patología clínica, los profesionales de la salud visual y ocular normalmente no lo registran. El objetivo de este artículo es presentar una revisión general de esta patología.
High Serum PCSK9 Is Associated With Increased Risk of New-Onset Diabetes After Transplantation in Renal Transplant Recipients
Authors: Eisenga Michele F. , Zelle Dorien M. , Sloan John H. , Gaillard Carlo A.J.M. , Bakker Stephan J.L. , Dullaart Robin P.F. 
Published: May 2017

OBJECTIVE
New-onset diabetes after transplantation (NODAT) is a major complication in renal transplant recipients (RTRs). Cholesterol metabolism has been linked to diabetes development. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is crucial in LDL receptor regulation. Its association with NODAT is unknown. We prospectively determined the association between serum PCSK9 levels and NODAT development and then with all-cause mortality, cardiovascular mortality, and renal graft failure.

RESEARCH DESIGN AND METHODS
In a university setting, nondiabetic RTRs recruited between 2001 and 2003 with a functional graft for ≥1 year were eligible. Serum PCSK9 was measured by ELISA. Cox proportional hazards analysis was used to assess the association of PCSK9 with the development of NODAT, all-cause mortality, cardiovascular mortality, and graft failure.

RESULTS
In 453 RTRs (age 51 ± 12 years, 56% male; 6.1 [2.7–11.7] years after transplantation), serum PCSK9 was 107.1 ± 43.4 μg/L. During a median follow-up of 10 years, 70 RTRs developed NODAT, 123 died, and 59 developed graft failure. NODAT occurred more frequently in the upper PCSK9 tertile (23%) versus the lowest two PCSK9 tertiles (12%; P &lt; 0.001). In crude Cox regression analyses, PCSK9 was significantly associated with development of NODAT (hazard ratio 1.34 [95% CI 1.10–1.63]) per SD change (P = 0.004). This association remained independent of adjustment for potential confounders, including statin use. PCSK9 was not associated with all-cause mortality, cardiovascular mortality, or graft failure.

CONCLUSIONS
Circulating PCSK9 is associated with NODAT in RTRs. The PCSK9 pathway may contribute to the pathogenesis of NODAT.
MEGALITH AND JAR BURIAL OF THE JAMBI HIGHLAND IN ARCHAEOLOGY AND ETHNOHISTORY
Authors: S. Budisantosa Tri Marhaeni 
Published: May 2017

One aspect of archaeological studies in highland of Jambi is ideology or belief existing within human mind. The ideology of the past society is not appeared directly through material culture.The ideological research, therefore, could approach closer to cultural system of the past with the supported by the endorsement of historical and ethnographical data of local community. This writingdiscusses development of such model to disclose the beliefs that playing a part in the construction of megaliths and burial jars in highland of Jambi. The problem is answered by relate the results of the discussion of archaeological data and ehtnohistorical data. Results of the discussion revealed that the archaeological data interpretation is supported by the etnhohistorical data.
SHORT INSCRIPTION FROM SANGGAR TEMPLE A HOMAGE TO BRAHMA
Authors: Istari T.M. Rita 
Published: May 2017

Sanggar temple is located on Penanjakan slope.. The hill is part of Wonogriyo of Pusungmalang village, Puspo regency, Pasuruan district. Sanggar temple suspected as place of worship to the God Brahma who dwells in Mount Bromo. On a series of research carried out in 2005-2008 by Yogyakarta Centre of Archaeology were found several short inscriptions around the temple to be praises used in religious rituals it is allegedly the people in the region. The tradition to sing praises by until the spread of Islam in Java. The adoption of Islam influence changes lasted praises. The contents of such literatur review espeally ancient writings are used to prove the assumptin.