bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusive Fitness-A Scientific Exploration of Wellness for Both Ables and Enables
Authors: Kaur Jasveen 
Published: September 2024

Abstract

The GoBhangra Workout is a culturally adaptive exercise program that combines traditional Punjabi Bhangra and Bollywood dance with tailored adaptive movements, thereby enhancing health outcomes for individuals with diverse abilities. This study examines initiatives pertaining to inclusive fitness, focusing on their physical and psychological health advantages, impediments to participation, and the influence of cultural components such as the GoBhangra Workout. The study employs a mixed-methods methodology, integrating a systematic literature review with an in-depth qualitative case study analysis to examine the effects, barriers, and facilitators associated with inclusive fitness programs. The systematic review elucidated trends and quantified health outcomes pertinent to inclusive exercise programs published from 2015 to 2023. Thematic analysis was performed on the qualitative data to identify key themes related to the physical and mental health impacts, as well as social and cultural benefits, of inclusive fitness. The qualitative analysis focused on the case study, derived from 15 semi-structured interviews. The quantitative analysis highlighted substantial advancements in both physical and mentally health outcomes that are associated with inclusion fitness programs, highlighting significant improvements in both health outcomes. The results of this study provide evidence-based recommendations for the expansion of these initiatives.
Stakeholder perceptions, challenges, and sustainable solutions for achieving safely managed sanitation in Kazakhstan: a case study from a cold region
Authors: Uteyeva Aiman , Lee Woojin , Templeton Michael R. 
Published: September 2024

ABSTRACT

In this paper, we present survey results from 30 sanitation stakeholders across the public and private sectors, professional associations, non-governmental organisations (NGOs), and households in the two coldest cities of Kazakhstan. The objectives were to identify the perceived sanitation challenges, document innovative, and traditional solutions employed by the stakeholders to manage sanitation challenges during the cold season, and to propose initiatives and policy interventions to alleviate pressing sanitation issues. Commonly encountered problems included improper installation of septic tanks (e.g. above the frost line) by non-professionals and the difficulty of households to access latrines during heavy snowfall events. Ninety-three percent of respondents expressed that foul odours and sewage overflows were their primary concerns, with only 7% reporting health impacts as a primary concern. There were significant differences in the viewpoints of the respondents regarding the extent of sanitation infrastructure maintenance or upgrades needed in the two cities, suggesting regional differences across the country rather than a uniform national situation. In the context of Kazakhstan, local NGOs were identified as playing a key role in engaging with households to co-devise affordable and sustainable sanitation solutions that are suitable for cold regions, which can then be communicated to other sanitation stakeholders, including the public sector.
Risk factors associated with Helicobacter pylori infection among patients attending private clinics in Borama district, Somaliland
Authors: Yusuf Abdirashiid Saleban , Adebisi Sunday Adesina , Osiri Josiah Odongo 
Published: September 2024

ABSTRACT

Risk factors associated with Helicobacter pylori infection among patients attending private clinics in Borama district, Somaliland, are studied. We specifically investigated the association among the use of non-steroidal anti-inflammatory drugs, the users’ socioeconomic status, and the household hygiene practice of people with H. pylori infection attending the Borama private clinic. Helicobacter pylorus (H. pylori) is a Gram-negative spiral-shaped bacterium that infects gastric-type epithelium, and it is probably the most common bacterial agent in humans after Streptococcus mutans, which causes dental caries. H. pylori infection is now recognized as a worldwide problem and it is the most common cause of chronic gastritis and is strongly linked to peptic ulcer disease and gastric cancer. The prevalence of H. pylori infection is high in less-developed Asian countries like India, Bangladesh, Pakistan, and Thailand, and is acquired at an earlier age than in the more developed Asian countries like Japan and China. H. pylori infection is a global public health problem, affecting over 50% of the population worldwide.
Exploring the Potential Effects and Mechanism of Astragalus Membranaceus in Treating Ischemic Heart Failure Based on Network Pharmacology
and Experimental Verification
Authors: Xing Chaoqun , Xing Xiao-Liang , Luo Hai , Huang Minjiang , Zhang Xuemei , Yao Zhiyong 
Published: September 2024

Background:
Astragalus membranaceus (AM) is a traditional Chinese medicine that
has been clinically utilized as an adjunctive therapy for the treatment of myocardial ischemia and
heart failure; however, its precise molecular mechanism of action remains unknown.

Objective:
This study aims to investigate the potential pharmacological effects and molecular
mechanism of AM in the treatment of ischemic heart failure (IHF) using network pharmacology
methods, molecular docking technology, and in vitro experiments.

Methods:
The active components and targets of AM were obtained from the TCMSP databases,
while the disease targets of IHF were retrieved from GeneCards and OMIM databases. The
analysis of overlapping targets between AM and IHF mainly included active compounds-targets
network, PPI network, and GO and KEGG enrichment analysis. The association between active
compounds and target proteins was verified through molecular docking. Additionally, an in vitro
experimental model was used to evaluate the accuracy of the forecast results.

Results:
The network pharmacological analysis revealed that quercetin, kaempferol, 7-Omethylisomucronulatol,
formononetin, and isorhamnetin were the core active components of
AM in treating IHF. The core targets included AKT1, IL6, IL1B, PTGS2, CASP3, MMP9, and
HIF1A. The molecular docking results demonstrated a strong binding affinity between these active
components and targets. The KEGG pathway analysis suggested that the PI3K-AKT signaling
pathway might play a central role in mediating AM's therapeutic effects on IHF. In vitro experiments
demonstrated that AM treatment enhanced cell viability, reduced heart failure biomarkers,
and suppressed cell apoptosis. Furthermore, the western blot analyses indicated that
AM treatment effectively regulated AKT1 phosphorylation in an experimental model of IHF.

Conclusion:
Through integrated network pharmacological analysis, molecular docking technology,
and in vitro experimental validation, it was demonstrated that AM can effectively mitigate
IHF through activating PI3K-AKT signaling pathway. These findings significantly advance our
understanding of the molecular mechanisms in IHF treatment and contribute further to promoting
the clinical application of AM.

other:
none
Formulation and Characterization of Pomegranate-beetroot Gummies: A Healthy Confectionary Approach
Authors: Malik Manisha , Dewan Aastha , Arya Devrat , Singh Ajay , Kumar Krishan , Luthra Ankur 
Published: September 2024

Purpose/Objective:
Gummies are a popular confectionary product, especially among
children, and keeping in view, improvisation in its nutritional and sensorial characteristics is the
need of the hour.

Methodology:
For this purpose, juices of pomegranate and beetroot were incorporated using different
proportions. Six formulations were studied in which the ratio of pomegranate to beetroot
juices was 60:40, 70:30, 80:20, 40:60, 30:70, and 20:80. Physicochemical characteristics such as
moisture, ash, pH, total soluble solids (TSS), total phenolic content (TPC) and antioxidant activity
(DPPH) and, overall acceptability, color (L, a and b values), textural and microbiological characteristics
of gummies were studied to select appropriate formulation.

Results:
Highest TPC (0.19 mgGAE/g), antioxidant activities (84.1 mg/100g), sensory acceptability
(8) and resilience (92.7) were observed in sample having highest proportion of pomegranate
juice (80:20) and moisture (18%), ash (0.08%), pH (3.915), and TSS (73.2 °Brix) of this formulation
were within the specified range as stated for gummies.

Conclusion:
Thus, gummies prepared with 80% pomegranate juice and 20% beetroot juice may
serve as delicious healthy confectionary without addition of synthetic color and flavor.
Design and Synthesis of (2,3-dichloro-4-(3-(substituted Phenyl)acryloyl) phenoxy) Substituted Carboxylic Acid as Potent Glutathione-s-transferase
Inhibitors, Anti-breast-cancer Agents and Enhancing Therapeutic Efficacy of Anticancer Agents
Authors: Qayyum Afreen Begum A. , Ali Syed Ayaz , Mokale Santosh N. 
Published: September 2024

Background:
Ethacrynic acid is a dynamic agent holding alpha-beta unsaturated carbonyl
unit in its structure which imparts superiority and extraordinary advantage of displaying multiple
biological activities such as anticancer, antiviral, anti-malarial effect, diuretic effect and inhibits the
Glutathione-s-transferase p1-1 enzyme which produces hindrance in the pathway of apoptosis. Ethacrynic
acid is an inhibitor of Glutathione-s-transferases. EtA by itself act as an anti-cancer agent at
higher concentration and also increases effectiveness of other compounds used in cancer treatment
by preventing their detoxification, all these facts attracted our attention to develop and evaluate
novel structural analogues of ethacrynic acid for their inhibitory effect on GSTs and anti-cancer
activity in breast cancer.

Objective:
By attending rational drug design perspectives the research is aimed to develop and
evaluate novel structural analogues of ethacrynic acid as Inhibitors of GSTs enzyme and with antibreast
cancer activity.

objective:
By attending rational drug design perspectives the present research study is focused on development and evaluation of novel structural analogues of ethacrynic acid as Inhibitors of Glutathione-s-transferase enzyme and anti-breast cancer agents.

Methods:
Designed compounds were synthesized as per convenient route shown in the scheme of
synthesis. Molecular docking studies were done against GSTP1-1 (PDB:3HJO). Structures of novel
synthesized molecules were confirmed by spectral characterization such as FTIR, 1HNMR,
13CNMR and Mass spectrometry. ADME studies were done to ensure safety and drug like properties
of the compounds. Ten structural analogues of ethacrynic acid were synthesized and evaluated
for their inhibitory effect on activity of Glutathione-s-transferases which was measured by performing
assay (Habig et al) method. In-vitro anti-breast cancer activity was done on MCF-7 and
MDAMB-231 cell line by MTT assay.

Results:
Compound A3, A5 and A6 were found with greater inhibition of the activity of GSTs and
maximum anti-proliferative activity in breast cancer.

Conclusion:
We have effectively developed novel compounds possessing structural resemblance
with ethacrynic acid Compounds of the series has shown moderate to higher inhibitory effect on
GSTs and anti-proliferative activity in breast cancer. The compound A3 was found to be promising
agent with high level of potency in each biological response. The research studies presented here
may be an enlightening path in development of novel therapeutic agents with high level of inhibition
in the activity of GSTs and anti-breast cancer effect.
Novel Design for Multi-Epitope Vaccines of COVID-19 and Critical In-Silico Assessment Steps
Authors: Lan Tian , Su Shuquan , Ping Pengyao , Li Jinyan 
Published: September 2024

Introduction:
The coronavirus disease COVID-19, caused by the SARS-CoV-2 virus,
was a global pandemic that happened in March of 2020. The virus was mutated into several widelyspread
strains such as Alpha, Beta, Gamma, Delta, and Omicron, and is continuing its unpredictable
mutation.

Method:
Multi-Epitope Vaccine (MEV) is one type of recombinant vaccine with its sequence containing
multiple epitopes and is considered as an effective way to fight against the infectious disease.
Previous in-silico approaches to MEV construction have been constrained by their inability to
predict molecular conformation structures accurately, consequently leading to inaccurate property
evaluations. In this work, we designed a novel MEV for the future prevention of COVID-19 or
similar diseases. We set strict thresholds to screen for epitope candidates in order to construct highly
effective MEV and use the latest ColabFold (a modified version of AlphaFold2) to predict accurate
tertiary structures of the MEV.

Results:
We especially studied epitopes from the main proteins of SARS-CoV-2 (i.e., the envelope,
membrane, nucleo-, and spike proteins) that can provoke immunity response of B-cells, helper Tcells
(Th), and cytotoxic T-cells (CTL), then we combined them through amino acid linkers to construct
the MEV. We evaluated the vaccine in terms of its physicochemical properties, population
coverage, safety for use, secondary and tertiary structure, docking immunity response, and immu
nity response eliciting capability.

Conclusion:
These in-silico assessments demonstrate that our proposed vaccine can elicit effective
immune responses and it is safe to use with a high population coverage.
AI-Supported Digital Microscopy Diagnostics in Primary Health Care Laboratories: Protocol for a Scoping Review
Authors: von Bahr Joar , Diwan Vinod , Mårtensson Andreas , Linder Nina , Lundin Johan 
Published: September 2024

Background
Digital microscopy combined with artificial intelligence (AI) is increasingly being implemented in health care, predominantly in advanced laboratory settings. However, AI-supported digital microscopy could be especially advantageous in primary health care settings, since such methods could improve access to diagnostics via automation and lead to a decreased need for experts on site. To our knowledge, no scoping or systematic review had been published on the use of AI-supported digital microscopy within primary health care laboratories when this scoping review was initiated. A scoping review can guide future research by providing insights to help navigate the challenges of implementing these novel methods in primary health care laboratories.

Objective
The objective of this scoping review is to map peer-reviewed studies on AI-supported digital microscopy in primary health care laboratories to generate an overview of the subject.

Methods
A systematic search of the databases PubMed, Web of Science, Embase, and IEEE will be conducted. Only peer-reviewed articles in English will be considered, and no limit on publication year will be applied. The concept inclusion criteria in the scoping review include studies that have applied AI-supported digital microscopy with the aim of achieving a diagnosis on the subject level. In addition, the studies must have been performed in the context of primary health care laboratories, as defined by the criteria of not having a pathologist on site and using simple sample preparations. The study selection and data extraction will be performed by 2 independent researchers, and in the case of disagreements, a third researcher will be involved. The results will be presented in a table developed by the researchers, including information on investigated diseases, sample collection, preparation and digitization, AI model used, and results. Furthermore, the results will be described narratively to provide an overview of the studies included. The proposed methodology is in accordance with the JBI methodology for scoping reviews.

Results
The scoping review was initiated in January 2023, and a protocol was published in the Open Science Framework in January 2024. The protocol was completed in March 2024, and the systematic search will be performed after the protocol has been peer reviewed. The scoping review is expected to be finalized by the end of 2024.

Conclusions
A systematic review of studies on AI-supported digital microscopy in primary health care laboratories is anticipated to identify the diseases where these novel methods could be advantageous, along with the shared challenges encountered and approaches taken to address them.

International Registered Report Identifier (IRRID)
PRR1-10.2196/58149
Becoming, Rheology and Deterritorialization : on Sensibility Illustration in The White Peacock from the Affect Theory
Authors: Xiaomeng Lin 
Published: September 2024

The White Peacock by D.H. Lawrence in the Victorian era distinguishes itself with delieantion in affect, different from other works with bold strokes of sexual love. The factors and the change of identity in affective entanglements between Lettie, George and Leslie reflect the great emphasis of the emotion involved in love on the representation of the subject. The dynamics of affect is pivotal in delineating the interplay between the self and the other, the rhizomatic “becoming” subjectivity, and the rheology within the narrative. This paper explicates the exerted power of affect as the change of intensity of life, the becoming to new identities attributed to affect, and the deterritorializaton and rheology in Lettie’s subjectivity by drawing upon Gilles Deleuze’s critique of affect theory by Spinoza. The examination of Lettie’s marital and romantic choices under this perspective insinuates the vicissitudes of Victorian women's vitality amidst the complexities of love, the ideological nomadism of female subjects, and their emancipation from the entrenched frameworks of subjectivity. The inescapable outcome of their life trajectories and innate capacity for treating different affect movement. Although the affective power leads to the hybridity and contradiction of her action, her subjective consciousness and desire of self-confirmation against regulated, traditional love ethics are elucidated. This paper shed lights on the analytical lens from the empowerment of the affect on the subjectivity, that experiences of life energetic flow vary across diverse contexts, reflecting the multifaceted nature of subjectivity.
Excel Solver and What-If Analysis: Optimizing Tax Refunds Involving Education Credits and Scholarships
Authors: Axelton Zhuoli , Boneck Robin , Lee Jonathan E. 
Published: September 2024

ABSTRACT
This case teaches students advanced Excel modeling functions and analytic tools like Solver and What-If Analysis. The case scenario involves preparation of a student tax return that focuses on minimizing federal income tax liability by utilizing education credits and reporting scholarships as taxable income. Solver is used to determine the optimal allocation of non-tuition-based scholarships or grants as taxable income. What-If Analysis is then used to demonstrate how a practitioner might illustrate the tax outcomes and plans in different scenarios. Additionally, critical thinking and analysis are required of students to explain how additional income affects both nonrefundable and refundable credits to find the best outcome for the client. Considering that the current CPA evolution curriculum focuses more on analytical skills, tax planning, and personal financial planning, students will benefit academically, professionally, and personally from the knowledge and skills learned in this case.
JEL Classifications: A22; H24; K34.
The superior value of radiomics to sonographic assessment for ultrasound-based evaluation of extrathyroidal extension in papillary thyroid carcinoma: a retrospective study
Authors: Zhu Hui , Luo Hongxia , Li Yanyan , Zhang Yuhua , Wu Zhijing , Yang Yan 
Published: September 2024

Abstract

Background
Extrathyroidal extension was related with worse survival for patients with papillary thyroid carcinoma. For its preoperative evaluation, we measured and compared the predicting value of sonographic method and ultrasonic radiomics method in nodules of papillary thyroid carcinoma.

Patients and methods
Data from 337 nodules were included and divided into training group and validation group. For ultrasonic radiomics method, a best model was constructed based on clinical characteristics and ultrasonic radiomic features. The predicting value was calculated then. For sonographic method, the results were calculated using all samples.

Results
For ultrasonic radiomics method, we constructed 9 models and selected the extreme gradient boosting model for its highest accuracy (0.77) and area under curve (0.813) in validation group. The accuracy and area under curve of sonographic method was 0.70 and 0.569. Meanwhile. We found that the top-6 important features of xgboost model included no clinical characteristics, all of whom were high-dimensional radiomic features.

Conclusions
The study showed the superior value of ultrasonic radiomics method to sonographic method for preoperative detection of extrathyroidal extension in papillary thyroid carcinoma. Furthermore, high-dimensional radiomic features were more important than clinical characteristics.
Involvement of Male Partners in Sustaining Interventions for Preventing Mother-to-Child Transmission of HIV Among Women with HIV
Authors: Malindi Fulufhedzani C. , Maputle Maria S. 
Published: September 2024

Background and Objective
Although male partners are eager to support the implementation of prevention of mother-to-child transmission (PMTCT) of HIV programs, several obstacles prevent them from participating. The purpose of this study was to explore the support of male partners of HIV-positive women in sustaining the implementation of PMTCT interventions.

Methods
This study adopted a qualitative approach. The case study research design was used to generate an in-depth understanding of the factors that hinder male participation in PMTCT interventions. Non-probability purposive sampling was used to 20 sample participants. Data was collected from two focus group discussions and analyzed using open coding. Trustworthiness was achieved by credibility, transferability, and confirmability. Adherence to ethical principles was upheld.

Results
Findings revealed two themes, perceived practices that hinder the provision of support and perceived support provided to sustain PMTCT intervention during childbirth. Sustaining PMTCT interventions included how the male partner adheres to interventions that prevent the transmission of the virus, like consistent condom use, especially during breastfeeding, support in exclusive breastfeeding, adherence to ART, and limiting the use of cultural practices.

Conclusion and Global Health Implications
The involvement of males in the interventions of PMTCT has been found to improve the sustainability of eliminating transmission of the virus to the baby. All clinics were recommended to be men user-friendly to encourage men to accompany their partners. Men are to be actively involved during decision-making and physical examination, where possible. Workshops and information-sharing sessions for men forums and community members on PMTCT interventions to be conducted.