bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous intraoperative neuromonitoring in thyroid surgery: Safety analysis of 400 consecutive electrode probe placements with standardized procedures
Authors: Mangano Alberto , Kim Hoon Yub , Wu Chei‐Wei , Rausei Stefano , Hui Sun , Xiaoli Liu , Chiang Feng‐Yu , Roukos Dimitrios H. , Lianos Georgios D. , Volpi Erivelto , Dionigi Gianlorenzo 
Published: November 2015

ABSTRACTBackgroundContinuous intraoperative neuromonitoring (C‐IONM) is a new technology and it is appropriate to analyze its safety.MethodsC‐IONM was performed according to a standardized technique to control any adverse events and electrode positioning issues.ResultsFour hundred vagal nerve dissections were analyzed considering vagal nerve diameter, mean time effort for C‐IONM probe positioning, and electrode dislocation rate. A significant superior dislocation rate in case of: (a) when a 3 mm automatic periodic stimulating (APS) electrode size was used in a vagal nerve diameter <2 mm; (b) anterior access; and (c) vagal nerve A subtype in relation (p < .05). No related additional local or systemic morbidity was registered in this series. There was a statistically significant positive relationship between increased diameter of vagal nerve and increased electromyography (EMG) amplitude (p = .03). There was also a significant increase of amplitude between initial and final vagal nerve stimulation in uneventful cases (p = .02).ConclusionWe analyzed the technical issues to achieve improved vagal nerve critical view of safety dissection, stimulation, and C‐IONM probe placement. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1568–E1574, 2016
Degree of nephrotoxicity after intermediate‐ or high‐dose cisplatin‐based chemoradiotherapy in patients with locally advanced head and neck cancer
Authors: Driessen Chantal M. L. , Uijen Maike J. M. , van der Graaf Winette T. A. , van Opstal Claudia C. M. , Kaanders Johannes H. A. M. , Nijenhuis Tom , van Herpen Carla M. L. 
Published: November 2015

AbstractBackgroundThe purpose of this study was to compare the occurrence of cisplatin‐induced nephrotoxicity between concomitant chemoradiotherapy with high versus intermediate‐dose cisplatin.MethodsOne hundred forty‐four patients with locally advanced head and neck or nasopharyngeal cancer (NPC) were included; 40 patients received cisplatin 100 mg/m2 (high dose) on days 1, 22, and 43, and 104 patients received cisplatin 40 mg/m2 weekly (intermediate dose) during 6 weeks in combination with radiotherapy.ResultsDuring treatment with intermediate‐dose cisplatin, 6.7% developed an increase of ≥50% serum creatinine versus 60.0% treated with high‐dose cisplatin (p < .05). Nephrotoxicity (all grades) scored by Common Toxicity Criteria for Adverse Events (CTCAE) version 3.0 or CTCAE version 4.03 was 53% and 100% in the high‐dose group and 4.8% and 68% in the intermediate‐dose group, respectively.ConclusionSignificantly less nephrotoxicity occurs during chemoradiotherapy with intermediate‐dose cisplatin compared with high‐dose cisplatin. The CTCAE version 4.03 seems to be more appropriate in scoring nephrotoxicity than the CTCAE version 3.0. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1575–E1581, 2016
Management of the cervico‐petrous internal carotid artery in class C tympanojugular paragangliomas
Authors: Bacciu Andrea , Prasad Sampath Chandra , Sist Natalie , Rossi Giulia , Piazza Paolo , Sanna Mario 
Published: November 2015

AbstractBackgroundManagement of the cervical and petrous internal carotid artery (ICA) is frequently required in Fisch class C tympanojugular paragangliomas (TJPs). The purpose of this study was to discuss the perioperative intervention of the ICA in patients who underwent surgical resection of a TJP.MethodsA retrospective study of 237 patients surgically treated for Fisch class C TJPs was done to identify cases that required ICA management.ResultsManagement of the ICA was required in 176 patients (74.2%). Forty‐two patients required just an ICA decompression, 88 underwent a subperiosteal dissection, 19 underwent subadventitial dissection without intraluminal stenting, 17 underwent subadventitial dissection with intraluminal stenting, and 12 underwent arterial resection after permanent balloon occlusion. There were no complications associated with the endovascular procedures. Gross total tumor resection was achieved in 91.5% of the cases.ConclusionPreoperative endovascular intervention, in selected cases, facilitates gross total tumor removal and significantly reduces the risk of an intraoperative ICA injury. © 2015 Wiley Periodicals, Inc. Head Neck 38: 899–905, 2016
Human papillomavirus and induction chemotherapy versus concurrent chemoradiotherapy in locally advanced oropharyngeal cancer: The Dana Farber Experience
Authors: Lorch Jochen H. , Hanna Glenn J. , Posner Marshall R. , O'Neill Anne , Thotakura Vijaya L. , Limaye Sewanti A. , Rabinowits Guilherme , Sher David J. , Tishler Roy B. , Haddad Robert I. 
Published: November 2015

AbstractBackgroundHuman papillomavirus (HPV) infection indicates favorable prognosis in oropharyngeal squamous cell carcinoma (SCC). The purpose of this study was for us to assess the impact of HPV in patients treated with sequential therapy versus concomitant chemoradiotherapy (CRT).MethodsPatients with stage III and IVA and B oropharyngeal SCC were reviewed spanning 10 years.ResultsAmong 500 cases, 291 (58%) received CRT versus 209 (42%) sequential therapy. HPV status was known in 279 of patients (56%) and positive in 77% (determined by polymerase chain reaction [PCR; 91%], p16 immunohistochemical [IHC], or both). Median follow‐up was 2.8 years. Overall survival (OS) did not differ for sequential therapy versus CRT overall (hazard ratio [HR] = 0.90; p = .66; 3‐year OS = 86% and 87%) or within HPV‐positive patients (HR = 0.89; p = .81; 3‐year OS = 91% and 91%) or within HPV‐negative patients (HR = 0.55; p = .32; 3‐year OS = 85% and 75%).ConclusionSurvival for all patients was high and notable for HPV‐negative patients treated with sequential therapy. Further studies in this patient population are warranted. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1618–E1624, 2016
Molecular profiling of head and neck squamous cell carcinoma
Authors: Feldman Rebecca , Gatalica Zoran , Knezetic Joseph , Reddy Sandeep , Nathan Cherie‐Ann , Javadi Nader , Teknos Theodoros 
Published: November 2015

AbstractBackgroundHead and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents.MethodsSeven hundred thirty‐five patients with advanced HNSCC (88 with known human papillomavirus [HPV] status), were profiled using multiple platforms (gene sequencing, gene copy number, and protein expression).ResultsAmong the entire patient population studied, epidermal growth factor receptor (EGFR) was the protein most often overexpressed (90%), TP53 gene most often mutated (41%), and phosphatidylinositol 3‐kinase (PIK3CA) most often amplified (40%; n = 5). With the exception of TP53 mutation, other biomarker frequencies were not significantly different among HPV‐positive or HPV‐negative patients. PIK3CA mutations and phosphatase and tensin homolog (PTEN) loss are frequent events, independent of HPV status. The immune response‐modulating programmed cell death 1 (PD1) and programmed cell death ligand 1 (PDL1) axis was active across sites, stages, and HPV status.ConclusionMolecular profiling utilizing multiple platforms provides a range of therapy options beyond standard of care. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1625–E1638, 2016
Psychometric evaluation of the Swallowing Outcomes After Laryngectomy (SOAL) patient‐reported outcome measure
Authors: Govender Roganie , Lee Mary T. , Drinnan Michael , Davies Tarni , Twinn Claire , Hilari Katerina 
Published: November 2015

AbstractBackgroundThe purpose of this study was to evaluate the psychometric properties of the Swallowing Outcomes After Laryngectomy (SOAL) in a large group of people who underwent a laryngectomy.MethodsWe conducted a cross‐sectional psychometric study of laryngectomy patients (minimum 3 months posttreatment) attending routine hospital follow‐up for the psychometric evaluation of SOAL.ResultsOne hundred ten people participated in this study. Thirteen percent of the patients had a laryngectomy, 63% had laryngectomy with radiotherapy, and 24% had laryngectomy with chemoradiation therapy. The SOAL showed good quality of data (minimal missing data and floor effects); good internal consistency (α = 0.91); and adequate test–retest reliability (intra‐class correlation coefficient = 0.73). In terms of validity, it differentiated people by treatment group (F(2,85) = 8.02; p = .001) and diet texture group (t(102) = −7.33; p < .001).ConclusionThe SOAL demonstrates good validity and has potential for use in research. Further study is required to determine its clinical application. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1639–E1645, 2016
Recent advances in optical diagnosis of oral cancers: Review and future perspectives
Authors: Singh S.P. , Ibrahim Ola , Byrne Hugh J. , Mikkonen Jopi W. , Koistinen Arto P. , Kullaa Arja M. , Lyng Fiona M. 
Published: November 2015

ABSTRACTOptical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed, and cost, and these label‐free, noninvasive methods have the potential to change the future workflow of cancer management. The oral cavity is particularly accessible and, thus, such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. After an introduction to the epidemiology and etiological factors associated with oral cancers currently used, diagnostic methods and their limitations are presented. A thorough review of fluorescence, infrared absorption, and Raman spectroscopic methods in oral cancer diagnosis is presented. The applicability of minimally invasive methods based on serum/saliva is also discussed. The review concludes with a discussion on future demands and scope of developments from a clinical point of view. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2403–E2411, 2016
Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review
Authors: Bur Andrés M. , Lin Alexander , Weinstein Gregory S. 
Published: November 2015

ABSTRACTPerineural invasion (PNI) is widely regarded as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Treatment guidelines recommend adjuvant radiotherapy (RT) for patients with adverse pathologic features, including PNI. The purpose of this study was to systematically review the literature to determine if patients with PNI as their only indication for adjuvant therapy benefit from adjuvant RT. In total, 339 abstracts were reviewed for relevance leaving 85 articles, which were evaluated in detail. Thirteen retrospective studies addressed the role of adjuvant RT for patients with PNI. Evidence is lacking to recommend adjuvant RT for all patients with HNSCC with PNI. However, the literature suggests that large nerve or multifocal PNI may predict worse outcome and may be a more appropriate indication for adjuvant therapy. We advocate that patients decide whether to undergo adjuvant therapy after a discussion of the limitations of current evidence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2350–E2357, 2016
Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate
Authors: Givi Babak , Eskander Antoine , Awad Mahmoud I. , Kong Qin , Montero Pablo H. , Palmer Frank L. , Xu Wei , De Almeida John R. , Lee Nancy , O'Sullivan Brian , Irish Jonathan C. , Gilbert Ralph , Ganly Ian , Patel Snehal G. , Goldstein David P. , Morris Luc G.T. 
Published: November 2015

AbstractBackgroundWhether elective lymph neck dissection (ELND) is associated with improved survival in oral squamous cell carcinomas (SCC) of the maxillary alveolus/hard palate is not known.MethodsOne hundred ninety‐nine patients presenting de novo and receiving treatment for clinically node negative SCC of the maxillary alveolus/hard palate at 2 cancer centers between 1985 and 2011 were analyzed.ResultsForty‐two patients (21%) received ELND. Occult nodal metastases were present in 29% of the dissected necks. The ELND group had more T3 to T4 status tumors (62% vs 34%; p < .001) and positive‐margin resections (59% vs 38%; p = .019). Patients undergoing ELND experienced lower rates of neck recurrence (6% vs 21%; p = .031), superior 5‐year recurrence‐free survival (68% vs 45%; p = .026), and overall survival (86% vs 62%; p = .043). ELND was associated with a 2‐fold decrease in risk of recurrence in multivariable analysis.ConclusionELND was associated with lower rates of recurrence and improved survival in SCC of the maxillary alveolus/hard palate. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1688–E1694, 2016
Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx: A prospective clinical study
Authors: Volgger Veronika , Girschick Susanne , Ihrler Stephan , Englhard Anna Sophie , Stepp Herbert , Betz Christian Stephan 
Published: November 2015

AbstractBackgroundIn this trial, the ability of confocal laser endomicroscopy (CLE), a new imaging modality with a cellular resolution, to further differentiate primary flat lesions of the larynx was evaluated.MethodsFirst, an optical coherence tomography was used to filter out normal tissue and carcinoma. All other lesions (30 lesions in 19 patients) were investigated with CLE. The suspected diagnosis was compared to histopathology.ResultsOptical coherence tomography identified all noninvasive lesions. CLE provided further information with cellular resolution. In 2 of 30 cases, low image quality prevented classification. In laryngeal lesions (27 of 30), moderate to high‐grade dysplasia was correctly suspected in 10 of 10 cases (100%). Hyperplasia was overrated as dysplasia in 7 of 15 cases (46.7%). Sensitivity was 100% and specificity was 40%.ConclusionWhen used in conjunction with optical coherence tomography, CLE seems helpful for discrimination of noninvasive lesions, although it tends to overrate the severity of the changes. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1695–E1704, 2016
Influence of thyroid gland status on the thyroglobulin cutoff level in washout fluid from cervical lymph nodes of patients with recurrent/metastatic papillary thyroid cancer
Authors: Lee Jun Ho , Lee Hyun Chul , Yi Ha Woo , Kim Bong Kyun , Bae Soo Youn , Lee Se Kyung , Choe Jun‐Ho , Kim Jung‐Han , Kim Jee Soo 
Published: November 2015

AbstractBackgroundThe influence of serum thyroglobulin (Tg) and thyroidectomy status on Tg in fine‐needle aspiration cytology (FNAC) washout fluid is unclear.MethodsA total of 282 lymph nodes were prospectively subjected to FNAC, fine‐needle aspiration (FNA)‐Tg measurement, and frozen and permanent biopsies. We evaluated the diagnostic performance of several predetermined FNA‐Tg cutoff values for recurrence/metastasis in lymph nodes according to thyroidectomy status.ResultsThe diagnostic performance of FNA‐Tg varied according to thyroidectomy status. The optimized cutoff value of FNA‐Tg was 2.2 ng/mL. However, among FNAC‐negative lymph nodes, the FNA‐Tg cutoff value of 0.9 ng/mL showed better diagnostic performance in patients with a thyroid gland. An FNA‐Tg/serum‐Tg cutoff ratio of 1 showed the best diagnostic performance in patients without a thyroid gland.ConclusionApplying the optimal cutoff values of FNA‐Tg according to thyroid gland status and serum Tg level facilitates the diagnostic evaluation of neck lymph node recurrences/metastases in patients with papillary thyroid carcinoma (PTC). © 2015 Wiley Periodicals, Inc. Head Neck 38: E1705–E1712, 2016
Influence of social factors on patient‐reported late symptoms: Report from a controlled trial among long‐term head and neck cancer survivors in Denmark
Authors: Kjær Trille Kristina , Johansen Christoffer , Andersen Elo , Karlsen Randi , Nielsen Anni Linnet , Frederiksen Kirsten , Rørth Mikael , Ibfelt Else , Dalton Susanne Oksbjerg 
Published: November 2015

AbstractBackgroundThe incidence of head and neck cancer and morbidity and mortality after treatment are associated with social factors. Whether social factors also play a role in the prevalence of late‐onset symptoms after treatment for head and neck cancer is not clear.MethodsThree hundred sixty‐nine survivors completed questionnaires on late symptoms and functioning.ResultsSurvivors with short education were more likely to report severe problems than those with medium or long education. In the fully adjusted model, the risk for problems with opening the mouth remained significantly increased (odds ratio [OR] = 3.20; 95% confidence interval [CI] = 1.18–8.63). For survivors who lived alone, the adjusted ORs were significantly increased for physical functioning (2.17; 95% CI = 1.01–4.68) and trouble with social eating (OR = 2.26; 95% CI = 1.14–4.47).ConclusionSelf‐reported severe late symptoms were more prevalent in survivors with short education and in those living alone, suggesting differences in perception of late symptoms between social groups. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1713–E1721, 2016
Nuclear selenoproteins and genome maintenance
Authors: Zhang Xiong , Zhang Li , Zhu Jian‐Hong , Cheng Wen‐Hsing 
Published: November 2015

AbstractSelenium is an essential metalloid required for the expression of selenoproteins. While cells are constantly challenged by clastogens of endogenous and exogenous origins, genome integrity is maintained by direct repair of DNA damage, redox balance, and epigenetic regulation. To date, only five selenoproteins are experimentally demonstrated to reside in nucleus, exclusively or partially, including selenoprotein H, methionine‐R‐sulfoxide reductase 1, glutathione peroxidase‐4, thioredoxin reductase‐1, and thioredoxin glutathione reductase. All these five selenoproteins have demonstrated or potential roles in redox regulation and genome maintenance. Selenoprotein H is known to transactivate the expression of a couple of genes against oxidative stress. The thioredoxin reductase‐1b isoform delivers estrogen receptor‐α and ‐β to the nucleus. Nuclear glutathione peroxidase‐4 epigenetically and globally inhibits gene expression through the maintenance of chromatin compactness in testes. Continued studies on how these and additional nuclear selenoproteins regulate genome stability will have profound impact on advancing our understanding in selenium regulation of optimal health. © 2015 IUBMB Life, 68(1):5–12, 2016
Stratum corneum reservoir as a predictive method for in vitro percutaneous absorption
Authors: Hafeez Farhaan , Chiang Audris , Hui Xiaoying , Zhu Hanjiang , Kamili Faraz , Maibach Howard I. 
Published: November 2015

AbstractInteraction between drug and proteins and lipids in stratum corneum (SC) is an important pharmacokinetic parameter in early steps of absorption. Previous in vivo studies showed that the total amount of compound, regardless of properties, penetrating over a 96 h period could be predicted by the amount present in SC 30 min after application by a linear relationship. Validating this linear relationship through in vitro study would facilitate testing of transdermal drug delivery platforms. We aimed to determine in vitro penetration behavior across SC of humans by determining the relationship between quantity present in SC reservoir 30 min after application with 24 h skin absorption and penetration. In this study, use of the SC reservoir effect to predict absorption and penetration of topical compounds is reaffirmed with in vitro models involving human skin. These results indicate the amount in short‐term (30 min) SC reservoir predict long‐term (24 h) skin absorption and penetration, as characterized by statistically significant linear relationships determined via regression. This may be explained by the fact that SC is a rate‐limiting barrier to percutaneous drug transport. After molecules diffuse through SC barrier, passage into deeper dermal layers and systemic uptake occur relatively quickly. These results enable one to measure quantity in SC reservoir shortly after topical application as a proxy for absorption and penetration over longer periods. With respect to drug development and risk assessment of toxic substances, this may simplify assays attempting to quantitate penetration capacity. Further investigation with a larger range of compounds is needed to clarify the observations recorded here. Copyright © 2015 John Wiley & Sons, Ltd.
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency
Authors: Grassi Francesco , Tyagi Abdul Malik , Calvert John W , Gambari Laura , Walker Lindsey D , Yu Mingcan , Robinson Jerid , Li Jau-Yi , Lisignoli Gina , Vaccaro Chiara , Adams Jonathan , Pacifici Roberto 
Published: November 2015

ABSTRACT

Hydrogen sulfide (H2S) is a gasotransmitter known to regulate bone formation and bone mass in unperturbed mice. However, it is presently unknown whether H2S plays a role in pathologic bone loss. Here we show that ovariectomy (ovx), a model of postmenopausal bone loss, decreases serum H2S levels and the bone marrow (BM) levels of two key H2S-generating enzymes, cystathione β-synthase (CBS) and cystathione γ-lyase (CSE). Treatment with the H2S-donor GYY4137 (GYY) normalizes serum H2S in ovx mice, increases bone formation, and completely prevents the loss of trabecular bone induced by ovx. Mechanistic studies revealed that GYY increases murine osteoblastogenesis by activating Wnt signaling through increased production of the Wnt ligands Wnt16, Wnt2b, Wnt6, and Wnt10b in the BM. Moreover, in vitro treatment with 17β-estradiol upregulates the expression of CBS and CSE in human BM stromal cells (hSCs), whereas an H2S-releasing drug induces osteogenic differentiation of hSCs. In summary, regulation of H2S levels is a novel mechanism by which estrogen stimulates osteoblastogenesis and bone formation in mice and human cells. Blunted production of H2S contributes to ovx-induced bone loss in mice by limiting the compensatory increase in bone formation elicited by ovx. Restoration of H2S levels is a potential novel therapeutic approach for postmenopausal osteoporosis. © 2015 American Society for Bone and Mineral Research.
Applying Creativity Research to Cooking
Authors: Beghetto Ronald A. , Kaufman James C. , Hatcher Ryan 
Published: November 2015

AbstractWhat, if any, benefit might there be to applying creativity research to cooking? The purpose of this paper was to address this question. Specifically, we draw on concepts and theories from creativity research to help clarify what is meant by creative cooking. This includes exploring creative cooking through the lens of the 4‐C and Propulsion models of creativity. We close with a brief discussion of why applying creativity research to cooking is both beneficial and an area in need of further work.