bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping the vulnerability of banana production landscapes in Uganda to banana bunchy top disease
Authors: Ocimati Walter , Ogwal Geofrey , Tazuba Anthony Fredrick , Kubiriba Jerome , Tugume Joab , Erima Rockefeller , Okurut Wilson , Mahuku George , Kutunga David , Blomme Guy 
Published: September 2024

IntroductionBanana bunchy top disease (BBTD) caused by banana bunchy top virus (BBTV) poses a significant threat to Uganda’s food and income security.MethodsTo map BBTD spread and inform its management, a delimiting survey was undertaken covering the high-risk zones bordering the Democratic Republic of Congo (DR Congo) in the west, Rwanda and Tanzania in the south, and South Sudan in the north. BBTD is endemic in the DR Congo and present in Tanzania and Rwanda. The survey and environmental data were then used to map the vulnerability of Uganda’s banana landscapes.Results and discussionBBTD was only confirmed on 9% of sampled farms in north- and midwestern Uganda, with yield losses of 75% to 100%. Farmers observed BBTD over a 0.5–4.4-year period, suggesting a delayed detection. Suckers were the predominate planting materials used, increasing the risk of disease spread. Landscape suitability for BBTD was influenced by precipitation of the driest month, banana presence in 2016, land surface temperature difference (LSTD), the interaction between wind speed and LSTD, isothermality, wind speed, and the normalized difference vegetation index. These variables affect either or both the virus and aphid vector populations. Altitude did not influence the model, possibly due to disease introduction at mid to high altitudes through infected planting materials. The low-lying zones (around River Nile and Lakes Albert, Edward, and Victoria) are highly vulnerable. BBTD risk was low in northeastern Uganda with low banana production. The prediction map shows some suitable landscapes in the southwest that can expose this major banana production zone to BBTD, necessitating proactive measures.
The chronicles of inflammation: uncovering of distinct patterns of NET degradation products
Authors: Schoen Janina , Muñoz-Becerra Marco , Knopf Jasmin , Ndukwe Favour , Leppkes Moritz , Roth Dominik , Zeitler Anne , Frings Verena Gerlinde , Hohberger Bettina , Zeisberg Victoria , Muñoz Luis E. , Schett Georg , Herrmann Martin , Schauer Christine 
Published: September 2024

AimsNeutrophils and neutrophil extracellular traps (NETs) play multifaceted roles in inflammatory diseases. If the balance of NET formation and clearance is disturbed, they contribute to the development and pathogenesis of a plethora of inflammatory diseases. They promote inflammation and tissue degradation, and occlude vessels and ducts. This study focused on the presence of NET remnants generated during the clearance by nucleases and phagocytes.MethodsNET associated parameters in serum and plasma samples from various pathological conditions were investigated. We performed fluorescence-based assays to analyze the concentration of cell free DNA and the activity of neutrophil elastase. The presence of citrullinated histone H3, as well as neutrophil elastase- or myeloperoxidase-DNA complexes were examined employing enzyme-linked immunosorbent assays.ResultsWe analyzed samples from a variety of inflammatory conditions: (I) the rheumatic autoimmune diseases systemic lupus erythematosus, rheumatoid arthritis, and primary Sjögren’s syndrome (II) the inflammatory bowel diseases ulcerative colitis and Crohn’s disease (III) hidradenitits suppurativa and (IV) the viral-induced pathologies Coronavirus disease 2019 (COVID-19), and Post COVID Syndrome (PCS). While most NET associated parameters were detected in all inflammatory conditions, certain markers displayed disease-specific patterns. We compared the markers in terms of the concentration, correlations with each other and to disease activity, and their impact on sample variability. Systemic lupus erythematosus and rheumatoid arthritis were associated with increased levels of cell free DNA, and citrullinated histone H3 as well as neutrophil elastase-activity, respectively. Samples from patients with COVID-19 were characterized by elevated levels of neutrophil elastase- and myeloperoxidase-DNA complexes.ConclusionDifferent diseases are linked to characteristic patterns of NET associated parameters. These patterns offer insights into aberrant NET formation and clearance in different pathologies and may represent key targets for treatment development.
Effects of thyroid hormones modify the association between pre-pregnancy obesity and GDM: evidence from a mediation analysis
Authors: Alifu Xialidan , Chen Zexin , Zhuang Yan , Chi Peihan , Cheng Haoyue , Qiu Yiwen , Huang Ye , Zhang Libi , Ainiwan Diliyaer , Si Shuting , Peng Zhicheng , Zhou Haibo , Liu Hui , Yu Yunxian 
Published: September 2024

ObjectiveConflicting associations have been noted between thyroid function and gestational diabetes mellitus (GDM), with indications that pre-pregnancy BMI might influence these relationships. This study aims to examine the effect of thyroid hormone indices and their mediation role on the risk of GDM.MethodsPregnant women in our study were recruited from the Zhoushan Pregnant Women Cohort, Zhejiang Province, China. Participants who had their first prenatal follow-up and measured thyroid biomarkers in the first trimester, and oral glucose tolerance test (OGTT) records in the second trimester were eligible for inclusion in this study. The data were extracted from the Electronic Medical Record System database, at Zhoushan Maternal and Child Care Hospital. Maternal information about sociodemographic and health-related characteristics was extracted from the dataset. A unique personal identification number was provided to link both datasets. Multivariate logistic regression models were applied to investigate the correlations between thyroid hormone indices with GDM. The interaction effects of first-trimester thyroid hormone indices with pre-pregnancy BMI on GDM risk using a generalized linear regression model. Furthermore, the mediation analysis was used to explore the potential mediating effects of thyroid hormone indices on the relationship between pre-pregnancy BMI and GDM.ResultsOverall, 5895 pregnant women were included in this study. The first-trimester FT4, thyroid feedback quantile-based index (TFQI), thyrotropin index (TSHI) and thyrotroph thyroxine resistance index (TT4RI) levels were negatively associated with fasting blood glucose (FBG) and postprandial blood glucose (PBG2H) in the second trimester (all P&lt;0.05); FT3 and the FT3-to-FT4 ratio levels were positively associated with PBG1H and PBG2H in the second trimester (all P&lt;0.05). Moreover, there were significant correlations between the highest quartile FT4, FT3, FT3-to-FT4 ratio, TSHI, and TFQI with GDM (all P &lt; 0.05). The mediating effect of thyroid hormone parameters was 24.9% on the association between pre-pregnancy BMI and GDM.ConclusionsIn conclusion, the low FT4, high FT3-to-FT4 ratio, and low TFQI in the first trimester significantly increase the risk of GDM and should be given more attention. Furthermore, increased pre-pregnancy BMI might partially increase the risk of GDM by influencing the body’s thyroid function.
Nest placement accounts for thermal exposure secondarily: insights on multifarious selection
Authors: Harris Jonathan P. , McMurry Scott T. 
Published: September 2024

IntroductionMultifarious selective pressures can interact to affect species’ life history evolution, with predation and thermal exposure as selective pressures for nesting birds. Gray Vireos (Vireo vicinior) seemingly nest on the periphery of their nesting substrate because of lower predation rates, thereby increasing exposure to weather. We explored how nest placement and vegetation structure can be used to account for the increased weather exposure that Gray Vireos experience when nesting on the periphery of the nesting substrate to avoid predation.MethodsFor each Gray Vireo nest, we placed temperature and light data loggers at three locations: at the nest site, at the opposite orientation of the nest within the nesting tree, and at the same orientation of the nest but in an adjacent tree. To measure nest orientation, we recorded the inverse compass azimuth (+/−1°) from the nest toward the trunk of the nesting tree, while accounting for declination. Nest temperatures and light exposure were compared across various dimensions of nest placement.ResultsThe orientation of nests was cooler than the opposite orientation in the mornings and in the late afternoons. When nests were placed in hotter orientations (e.g., south- or west-facing), nests surrounded by more foliage or placed closer to the interior of trees could compensate for the increased exposure.DiscussionOur findings suggest Gray Vireos accounted for the increased thermal exposure that comes from predator avoidance by using secondary dimensions of nest placement. Specifically, nests could be placed in orientations with cooler temperatures or in hotter orientations with greater shade potential. These results highlight how the interactive selection pressures of predation risk and microclimate can be tiered and shape life-history characteristics of birds.
Cost-effectiveness of nivolumab plus gemcitabine-cisplatin as first-line treatment for advanced urothelial carcinoma in China and the United States
Authors: Xiang Guiyuan , Huang Yueyue , Gan Lanlan , Wang Linning , Ding Yunqi , Wu Yuanlin , Xing Haiyan , Liu Yao 
Published: September 2024

ObjectiveNivolumab, recently proven in a phase 3 clinical trial (CheckMate 901) to enhance survival when combined with gemcitabine-cisplatin for advanced urothelial carcinoma. This study aimed to assess its cost-effectiveness against gemcitabine-cisplatin alone, from US and Chinese payers’ perspectives.MethodsA partitioned survival model was established to assess the life-years, quality-adjusted life-years (QALYs), lifetime costs, and incremental cost-effectiveness ratios (ICERs) of nivolumab plus gemcitabine-cisplatin versus gemcitabine-cisplatin alone as first-line treatment for advanced urothelial carcinoma. Univariate, two-way, and probabilistic sensitivity analyses were conducted to assess the model’s robustness. Additionally, subgroup analyses were performed.ResultsNivolumab plus gemcitabine-cisplatin and gemcitabine-cisplatin achieved survival benefits of 4.238 life-years and 2.979 life-years for patients with advanced urothelial carcinoma, respectively. Compared with gemcitabine-cisplatin, nivolumab plus gemcitabine-cisplatin resulted in ICERs of $116,856/QALY in the US and $51,997/QALY in China. The probabilities of achieving cost-effectiveness at the current willingness-to-pay thresholds were 77.5% in the US and 16.5% in China. Cost-effectiveness could be reached if the price of nivolumab were reduced to $920.87/100mg in China. Subgroup analyses indicated that the combination had the highest probability of cost-effectiveness in patients under 65 or with an Eastern Cooperative Oncology Group (ECOG) performance-status score of 0 in the US and China.ConclusionNivolumab plus gemcitabine-cisplatin first-line treatment for advanced urothelial carcinoma results in longer life expectancy than gemcitabine-cisplatin, but is not cost-effective in China at current price. However, cost-effectiveness is likely to be achieved in most patient subgroups in the US.
Dissecting the causal links between gut microbiome, immune traits and polyp using genetic evidence
Authors: Zhou Cheng , Ye Xiaofeng , Liu Zhinuo , Liu Tong , Li Shanzheng , Yang Jinqiu , Wei Jingjing , Yu Peng , Jia Ran , Zhao Wenxia 
Published: September 2024

BackgroundPrevious research has demonstrated an association between gut microbiota and immune status with the development of several diseases. However, whether these factors contribute to polyps remains unclear. This study aims to use Mendelian randomization (MR) to investigate the causal relationship between gut microbiota and 4 types of polyps (nasal, gallbladder, colon, and gastric polyps), as well as to analyze the mediating role of immune traits.MethodsThis study utilized large-scale GWAS meta-analyses of gut microbiota (MiBioGen Consortium), 731 immune traits, and 4 types of polyps (one from the FinnGen Consortium and three from the NBDC Human Database). Univariate MR with the inverse variance weighted (IVW) estimation method was employed as the primary analytical approach. A two-step MR analysis was performed to identify potential mediating immune traits. Additionally, multivariable MR approach based on Bayesian model averaging (MR-BMA) was employed to further prioritize gut microbiota and immune traits associated with polyp development.ResultsBased on IVW method in univariate MR analysis, we identified 39 gut microbial taxa and 135 immune traits significantly causally associated with at least one type of polyp. For nasal polyps, 13 microbial taxa and 61 immune traits were causally associated. After false discovery rate (FDR) correction, CD3 on Central Memory CD8+ T cells and CD3 on CD4 regulatory T cells remained significant. MR-BMA identified 4 gut microbial taxa and 4 immune traits as high priority. For gallbladder polyps, 9 microbial taxa and 30 immune traits were causally associated. MR-BMA identified 8 microbial taxa and 6 immune traits as higher importance. For colon polyps, 6 microbial taxa and 21 immune traits were causally associated. MR-BMA identified 4 microbial taxa and 3 immune traits as higher importance. For gastric polyps, 12 microbial taxa and 33 immune traits were causally associated. Actinobacteria remained significant after FDR correction, and MR-BMA identified 7 gut microbial taxa and 6 immune traits as high priority. We identified 16 causal pathways with mediator directions consistent with the direction of gut microbiome-polyp association. Of these, 6 pathways were associated with the mechanism of nasal polyps, 1 with gallbladder polyps, 2 with colon polyps, and 7 with gastric polyps.ConclusionsOur findings shed light on the causal relationships between gut microbiota, immune traits, and polyp development, underscoring the crucial roles of gut microbiota and immune status in polypogenesis. Furthermore, these findings suggest potential applications in polyp prevention, early screening, and the development of effective strategies to reduce polyp risk.
Multimodal neuroimaging in Long-COVID and its correlates with cognition 1.8 years after SARS-CoV-2 infection: a cross-sectional study of the Aliança ProHEpiC-19 Cognitiu
Authors: Dacosta-Aguayo Rosalia , Torán-Monserrat Pere , Carmona-Cervelló Meritxell , León-Gómez Brenda Biaani , Mataró Maria , Puig Josep , Monté-Rubio Gemma , López-Lifante Victor M. , Maria Manresa-Domínguez Josep , Zamora-Putin Valeria , Montero-Alia Pilar , Chacón Carla , Bielsa-Pascual Jofre , Moreno-Gabriel Eduard , García-Sierra Rosa , Rodríguez-Pérez M. Carmen , Costa-Garrido Anna , Prado Julia G. , Martínez-Cáceres Eva , Mateu Lourdes , Massanella Marta , Violán Concepción , Lamonja-Vicente Noemí 
Published: September 2024

IntroductionThere is a growing interest in the effect of Long-COVID (LC) on cognition, and neuroimaging allows us to gain insight into the structural and functional changes underlying cognitive impairment in LC. We used multimodal neuroimaging data in combination with neuropsychological evaluations to study cognitive complaints in a cohort of LC patients with mild to moderate severity symptoms.MethodsWe conducted a 3T brain magnetic resonance imaging (MRI) study with diffusion tensor imaging (DTI) and functional MRI (fMRI) sequences on 53 LC patients 1.8 years after acute COVID-19 onset. We administered neuropsychological tests to evaluate cognitive domains and examined correlations with Tract-Based Spatial Statistics (TBSS) and resting state.ResultsWe included 53 participants with LC (mean age, 48.23 years; 88.7% females). According to the Frascati criteria, more than half of the participants had deficits in the executive (59%) and attentional (55%) domains, while 40% had impairments in the memory domain. Only one participant (1.89%) showed problems in the visuospatial and visuoconstructive domain. We observed that increased radial diffusivity in different white matter tracts was negatively correlated with the memory domain. Our results showed that higher resting state activity in the fronto-parietal network was associated with lower memory performance. Moreover, we detected increased functional connectivity among the bilateral hippocampus, the right hippocampus and the left amygdala, and the right hippocampus and the left middle temporal gyrus. These connectivity patterns were inversely related to memory and did not survive false discovery rate (FDR) correction.DiscussionPeople with LC exhibit cognitive impairments linked to long-lasting changes in brain structure and function, which justify the cognitive alterations detected.
Causal associations between constipation and pan-cancer: a bidirectional Mendelian randomization study
Authors: Dang Yongze , He Xinyu , Liu Xiaoxiao , Wang Yuchen , Geng Shangyi , Cheng Yutong , Ma Hongbing , Zhao Xixi 
Published: September 2024

ObjectiveObservational studies have suggested a potential association between constipation and several cancers. However, the causal relationship between constipation and cancer remains unclear. The purpose of this study is to explore the potential causal relationship between constipation and pan-cancer using Mendelian Randomization (MR) methods.MethodsWe performed a bidirectional MR analysis using publicly available summary data from Genome-Wide Association Studies (GWAS) statistics. The Inverse Variance Weighted (IVW) method was used as the main analysis method. We also used four MR methods: MR-Egger, Weighted Median, MR-PRESSO and MR.RAPS. Simultaneously, MR-Egger regression, Cochran’s Q test and MR-PRESSO Global test were used to estimate the pleiotropy and heterogeneity of SNPs. In addition, we performed “leave-one-out” analyses” to avoid bias caused by horizontal pleiotropy of individual SNPs.ResultsMR analysis revealed a potential causal association between constipation and the risk of colorectal cancer (CRC) [IVW (OR= 1.0021 (1.0003, 1.0039), P= 0.0234)], lung cancer (LC) [IVW (OR=1.0955 (1.0134, 1.1843), P=0.0218)], Oral cavity and pharyngeal cancer (OPC) [IVW (OR=1.4068 (1.0070, 1.9652), P=0.0454)], and Pancreatic cancer (PC) [IVW (OR=1.5580 (1.0659, 2.2773), P=0.0221)]. In addition, we explored causal relationships between constipation and 12 other types of cancers, including gastric cancer, esophageal cancer, skin melanoma and so on. All five methods yielded no evidence of a causal association between constipation and the risk of these cancer types. In the reverse MR analysis, there was no evidence of a causal association between cancer and the risk of constipation for all five methods.ConclusionOur bidirectional MR study suggests a potential relationship between constipation and an increased risk of CRC, LC OPC and PC. The underlying mechanisms behind these associations will need to be explored in future experimental studies.
Bibliometric and visual analysis of membranous nephropathy literature from 2010 to 2023
Authors: Chen Yirui , Liu Chen , Shen Hongnan , Su Pingping , Pang Liang , Zeng Congcong , Cheng Jinguo 
Published: September 2024

BackgroundMembranous glomerulonephritis, also known as membranous nephropathy (MN), is a common cause of nephrotic syndrome in adults. Despite extensive research on MN, bibliometric studies on the subject are scarce. Therefore, this study aimed to provide a visual analysis of global trends in membranous nephropathy research over the past 13 years.MethodsThis study conducted a bibliometric and visual analysis of global trends in MN research from 2010 to 2023. Articles related to MN were retrieved from the Web of Science Core Collection (WoSCC) database. Tools such as CiteSpace and VOSviewer were utilized to analyze publications, countries, institutions, authors, publishing journals, co-cited references, and keywords to identify the current state and future trends in MN research.ResultsThe analysis encompassed 1,624 publications, showing an annual increase from 2010 to 2023. The People’s Republic of China emerged as the most active country in this field, while France’s Sorbonne Universite and Institut National de la Sante et de la Recherche Medicale (Inserm) led in publication volume among academic institutions. Debiec Hanna stood out as the most prolific author. BMC Nephrology had the highest number of publications, making it the most favored journal in the field. The article with the greatest co-citation intensity was “Primary Membranous Nephropathy,” a review published in 2017.ConclusionThis study shows that there has been increasing interest in membranous nephropathy over the past 13 years. The most frequently encountered keywords were “membranous nephropathy” “nephrotic syndrome,” and “glomerulonephritis.” Analysis of emerging terms indicated that “a2 receptor antibody,” “domain containing 7a,” and “t cell” may remain prominent subjects of research in the forthcoming years. The findings highlight key research trends and areas of interest that can inform researchers, clinicians, and policymakers about the current state of MN research and help guide future research directions and clinical practice.
Exploring potential mediating mechanisms between maladaptive perfectionism and athlete burnout based on multi-theory perspectives
Authors: Kang Weiye , Gong Chen 
Published: September 2024

BackgroundAthletes with maladaptive perfectionism are vulnerable to experiencing a variety of psychological issues, such as burnout. Burnout in athletes can have detrimental effects on their performance and careers. The potential mechanisms by which fear of failure and self-handicapping explain the association between maladaptive perfectionism and athlete burnout remain understudied. This study examined their mediating role in the relationship between maladaptive perfectionism and athlete burnout.MethodsA total of 221 athletes were chosen to participate in a cross-sectional survey study. Data analysis was carried out using SPSS and AMOS structural equation modeling. The participants filled out self-report assessments on maladaptive perfectionism, fear of failure, self-handicapping, and athlete burnout.ResultsAnalyses indicated that maladaptive perfectionism positively predicts fear of failure, self-handicapping, and athlete burnout. Fear of failure positively predicts self-handicapping and athlete burnout, while self-handicapping also predicts athlete burnout. In addition to the direct pathway, we identified three mediating pathways through mediation analyses: (a) an independent mediation of fear of failure (b) an independent mediation of self-handicapping (c) a chained mediation of both.DiscussionThe results of this study provide a better understanding of the underlying mechanisms between maladaptive perfectionism and athletes burnout by considering fear of failure and self-handicapping as mediating variable factors. It is shown that the relationship between maladaptive perfectionism and athlete burnout can be partially explained through the mediating role of individuals’ fear of failure as well as self-handicapping behaviors. These insights offer a valuable foundation for the design of psychological interventions to address athlete burnout, enabling coaches and sport psychologists to develop more effective coping strategies for enhancing athletes’ psychological well-being and performance.