bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transactional interpretation and its evolution into the 21st century: An overview
Authors: Kastner Ruth E. 
Published: December 2016

AbstractThis essay provides a historical, philosophical, and critical overview of the development of the transactional interpretation (TI) of quantum mechanics. It is separated into two parts. Part I presents the history and development of TI from 1986 up to 2016 (the time of writing). Part II lays out current areas of divergence among researchers in TI.
Property Identity
Authors: Audi Paul 
Published: December 2016

AbstractThe question of how properties are individuated is extremely important. Consider the following proposals. To be in pain is to be in a certain neurological state. To be red is to appear red to normal observers in standard conditions. To be obligatory is to maximize the good. Each makes a claim of property identity. Each is a substantive metaphysical thesis of wide interest. None can be studied with due scrutiny in the absence of a general account of property identity. Here, I will survey existing accounts and suggest a new account in terms of grounding that has some advantages over the other candidates.
God and gratuitous evil (Part II)
Authors: Kraay Klaas J. 
Published: December 2016

AbstractIn contemporary analytic philosophy, the problem of evil refers to a family of arguments that attempt to show, by appeal to evil, that God does not (or probably does not) exist. Some very important arguments in this family focus on gratuitous evil. Most participants in the relevant discussions, including theists and atheists, agree that God is able to prevent all gratuitous evil, and that God would do so. On this view, of course, the occurrence of even a single instance of gratuitous evil falsifies theism. The most common response to such arguments attempts to cast doubt on the claim that gratuitous evil really occurs. The focus of these two survey papers will be a different response – one that has received less attention in the literature. This response attempts to show that God and gratuitous evil are compatible. If it succeeds, then the occurrence of gratuitous evil does not, after all, count against theism. In the prequel to this paper, I surveyed the literature surrounding the attempts by Michael Peterson and John Hick to execute this strategy. Here, I survey the attempts due to William Hasker, Peter van Inwagen, and Michael Almeida, respectively.
The status and factions theory of influence
Authors: Savage Scott V. , Melamed David 
Published: December 2016

AbstractWe review a relatively new theoretical research program on the joint effects of status and the distribution of opinions on social influence. The status and factions theory of influence combines sociological insights about status generalization with psychological research on how the distribution of opinions promotes social influence. To date, several published studies support the logic of the theory, including how the effect of status varies with the distribution of opinions and the intervening theoretical mechanism. The former has been replicated a number of times, but only one study to date has truly tested the mechanism. Uncertainty reduction has been found to explain some of the joint effects of status and the distribution of opinions on social influence, but there is room for improvement. Consequently, after we discuss the existing literature, we identify additional mechanisms that may be worth pursuing in the future and also some applications of the theory's utility.
Breadwinning and bread‐losing: Exploring opportunities to rework manhood
Authors: Myers Kristen , Demantas Ilana 
Published: December 2016

AbstractManhood in the USA today is at a crossroads. There are more models of how to be a man than ever before. And yet, despite myriad changes to the structures of work and family, the breadwinner ideology, or the heterogendered ideal that husbands should be the sole or primary earners in their families, persists in US society. This ideology affects the structure of work and family, regardless of whether individual people agree with it. Here, we discuss the breadwinner ideology and the ways that this meaning system tethers employment to masculinity and vice versa. We examine strategies for decoupling manhood from work and family and suggest ways to facilitate the undoing of gender.
Eccentric-Overload Training in Team-Sport Functional Performance: Constant Bilateral Vertical Versus Variable Unilateral Multidirectional Movements
Authors: Gonzalo-Skok Oliver , Tous-Fajardo Julio , Valero-Campo Carlos , Berzosa César , Bataller Ana Vanessa , Arjol-Serrano José Luis , Moras Gerard , Mendez-Villanueva Alberto 
Published: December 2016

Purpose:To analyze the effects of 2 different eccentric-overload training (EOT) programs, using a rotational conical pulley, on functional performance in team-sport players. A traditional movement paradigm (ie, squat) including several sets of 1 bilateral and vertical movement was compared with a novel paradigm including a different exercise in each set of unilateral and multi-directional movements.Methods:Forty-eight amateur or semiprofessional team-sport players were randomly assigned to an EOT program including either the same bilateral vertical (CBV, n = 24) movement (squat) or different unilateral multidirectional (VUMD, n = 24) movements. Training programs consisted of 6 sets of 1 exercise (CBV) or 1 set of 6 exercises (VUMD) × 6–10 repetitions with 3 min of passive recovery between sets and exercises, biweekly for 8 wk. Functional-performance assessment included several change-of-direction (COD) tests, a 25-m linear-sprint test, unilateral multidirectional jumping tests (ie, lateral, horizontal, and vertical), and a bilateral vertical-jump test.Results:Within-group analysis showed substantial improvements in all tests in both groups, with VUMD showing more robust adaptations in pooled COD tests and lateral/horizontal jumping, whereas the opposite occurred in CBV respecting linear sprinting and vertical jumping. Between-groups analyses showed substantially better results in lateral jumps (ES = 0.21), left-leg horizontal jump (ES = 0.35), and 10-m COD with right leg (ES = 0.42) in VUMD than in CBV. In contrast, left-leg countermovement jump (ES = 0.26) was possibly better in CBV than in VUMD.Conclusions:Eight weeks of EOT induced substantial improvements in functional-performance tests, although the force-vector application may play a key role to develop different and specific functional adaptations.
The Effect of Whole-Body Vibration on Subsequent Sprint Performance in Well-Trained Cyclists
Authors: Rønnestad Bent R. , Falch Gunnar Slettaløkken , Ellefsen Stian 
Published: December 2016

Postactivation-potentiation exercise with added whole-body vibration (WBV) has been suggested as a potential way to acutely improve sprint performance. In cycling, there are many competitions and situations where sprinting abilities are important.Purpose:To investigate the effect of adding WBV to warm-up procedures on subsequent cycle sprint performance.Methods:Eleven well-trained cyclists participated in the study. All cyclists performed a familiarization session before 2 separate test sessions in randomized order. Each session included a standardized warm-up followed by 1 of the following preconditioning exercises: 30 s of half-squats without WBV or 30 s of half-squats with WBV at 40 Hz. A 15-s Wingate sprint was performed 1 min after the preconditioning exercise.Results:Performing preconditioning exercise with WBV at 40 Hz resulted in superior peak power output compared with preconditioning exercise without WBV (1413 ± 257 W vs 1353 ± 213 W, P = .04) and a tendency toward superior mean power output during a 15-second all-out sprint (850 ± 119 W vs 828 ± 101 W, P = .08). Effect sizes showed a moderate practical effect of WBV vs no WBV on both peak and mean power output.Conclusions:Preconditioning exercise performed with WBV at 40 Hz seems to have a positive effect on cycling sprint performance in young well-trained cyclists. This suggests that athletes can incorporate body-loaded squats with WBV in preparations to specific sprint training to improve the quality of the sprint training and also to improve sprint performance in relevant competitions.
Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin
Authors: Shrestha Archana , Hendricks Matthew R. , Bomberger Jennifer M. , McClane Bruce A. 
Published: December 2016

ABSTRACT

Clostridium perfringens
enterotoxin (CPE) binds to claudin receptors, e.g., claudin-4, and then forms a pore that triggers cell death. Pure cultures of host cells that do not express claudin receptors, e.g., fibroblasts, are unaffected by pathophysiologically relevant CPE concentrations
in vitro
. However, both CPE-insensitive and CPE-sensitive host cells are present
in vivo
. Therefore, this study tested whether CPE treatment might affect fibroblasts when cocultured with CPE-sensitive claudin-4 fibroblast transfectants or Caco-2 cells. Under these conditions, immunofluorescence microscopy detected increased death of fibroblasts. This cytotoxic effect involved release of a toxic factor from the dying CPE-sensitive cells, since it could be reproduced using culture supernatants from CPE-treated sensitive cells. Supernatants from CPE-treated sensitive cells, particularly Caco-2 cells, were found to contain high levels of membrane vesicles, often containing a CPE species. However, most cytotoxic activity remained in those supernatants even after membrane vesicle depletion, and CPE was not detected in fibroblasts treated with supernatants from CPE-treated sensitive cells. Instead, characterization studies suggest that a major cytotoxic factor present in supernatants from CPE-treated sensitive cells may be a 10- to 30-kDa host serine protease or require the action of that host serine protease. Induction of caspase-3-mediated apoptosis was found to be important for triggering release of the cytotoxic factor(s) from CPE-treated sensitive host cells. Furthermore, the cytotoxic factor(s) in these supernatants was shown to induce a caspase-3-mediated killing of fibroblasts. This bystander killing effect due to release of cytotoxic factors from CPE-treated sensitive cells could contribute to CPE-mediated disease.

IMPORTANCE
In susceptible host cells,
Clostridium perfringens
enterotoxin (CPE) binds to claudin receptors and then forms pores that result in cell death. Using cocultures of CPE receptor-expressing sensitive cells mixed with CPE-insensitive cells lacking receptors for this toxin, the current study determined that CPE-treated sensitive cells release soluble cytotoxic factors, one of which may be a 10- to 30-kDa serine protease, to cause apoptotic death of cells that are themselves CPE insensitive. These findings suggest a novel bystander killing mechanism by which a pore-forming toxin may extend its damage to affect cells not directly responsive to that toxin. If confirmed to occur
in vivo
by future studies, this bystander killing effect may have significance during CPE-mediated disease and could impact the translational use of CPE for purposes such as cancer therapy.
Evaluation of exposure to pioglitazone and risk of prostate cancer: a nested case–control study
Authors: Boxall Naomi , Bennett Dimitri , Hunger Matthias , Dolin Paul , Thompson Paula L 
Published: December 2016

ObjectivesInvestigate potential association between pioglitazone exposure and risk of prostate cancer.Research design and methodsNested, matched case–control study. UK primary care data (Clinical Practice Research Datalink (CPRD) GOLD) linked to inpatient (Hospital Episode Statistics (HES)) and cancer registry (National Cancer Information Network (NCIN)) data. English men aged ≥40 years diagnosed with type 2 diabetes mellitus, January 1, 2001 to January 5, 2015. Cases, with prostate cancer diagnosis, matched with up to 4 controls by age, cohort entry date and region. ORs for association of exposure to pioglitazone to incident prostate cancer, adjusted for potential confounders.ResultsFrom a cohort of 47 772 men with 243 923 person-years follow-up, 756 definite cases of prostate cancer were identified. Incidence was 309.9/100 000 person-years (95% CI 288.6 to 332.8). Pioglitazone use was not associated with prostate cancer risk; adjusted OR 0.759, 95% CI 0.502 to 1.148. Analyses showed no difference when possible cases, prostate cancer in CPRD GOLD only, included (adjusted OR 0.726, 95% CI 0.510 to 1.034). No association when adjusted for channeling bias (OR 0.778, 95% CI 0.511 to 1.184) or limited to an index date prior to July 1, 2011 (adjusted OR 0.508, 95% CI 0.294 to 0.879), despite prostate-specific antigen screening occurring more frequently among cases than controls (81.6% of 756 definite cases cf. 24.2% of 2942 controls (p<0.01)). No association with duration of pioglitazone use, increasing pioglitazone dose or increasing time since initiation.ConclusionsIn this real-world, nested matched case–control study, exposure to pioglitazone was not associated with increased risk of prostate cancer.
Gender disparities in red blood cell transfusion in elective surgery: a post hoc multicentre cohort study
Authors: Gombotz Hans , Schreier Günter , Neubauer Sandra , Kastner Peter , Hofmann Axel 
Published: December 2016

ObjectivesA post hoc gender comparison of transfusion-related modifiable risk factors among patients undergoing elective surgery.Settings23 Austrian centres randomly selected and stratified by region and level of care.ParticipantsWe consecutively enrolled in total 6530 patients (3465 women and 3065 men); 1491 underwent coronary artery bypass graft (CABG) surgery, 2570 primary unilateral total hip replacement (THR) and 2469 primary unilateral total knee replacement (TKR).Main outcome measuresPrimary outcome measures were the number of allogeneic and autologous red blood cell (RBC) units transfused (postoperative day 5 included) and differences in intraoperative and postoperative transfusion rate between men and women. Secondary outcomes included perioperative blood loss in transfused and non-transfused patients, volume of RBCs transfused, perioperative haemoglobin values and circulating red blood volume on postoperative day 5.ResultsIn all surgical groups, the transfusion rate was significantly higher in women than in men (CABG 81 vs 49%, THR 46 vs 24% and TKR 37 vs 23%). Intransfusedpatients, the absolute blood loss was higher among men in all surgical categories while the relative blood loss was higher among women in the CABG group (52.8 vs 47.8%) but comparable in orthopaedic surgery. The relative RBC volume transfused was significantly higher among women in all categories (CABG 40.0 vs 22.3; TKR 25.2 vs 20.2; THR 26.4 vs 20.8%). On postoperative day 5, the relative haemoglobin values and the relative circulating RBC volume were higher in women in all surgical categories.ConclusionsThe higher transfusion rate and volume in women when compared with men in elective surgery can be explained by clinicians applying the same absolute transfusion thresholds irrespective of a patient's gender. This, together with the common use of a liberal transfusion strategy, leads to further overtransfusion in women.
Changes in the prevalence of breast feeding in preterm infants discharged from neonatal units: a register study over 10 years
Authors: Ericson Jenny , Flacking Renée , Hellström-Westas Lena , Eriksson Mats 
Published: December 2016

ObjectiveThere are indications that the prevalence of exclusively breastfed preterm infants is decreasing in Sweden. The objective was to investigate trends in exclusive breast feeding at discharge from Swedish neonatal units and associated factors in preterm infants.Design, setting and participantsThis is a register study with data from the Swedish Neonatal Quality Register. Data from 29 445 preterm infants (gestational age (GA) <37 weeks) who were born during the period 2004–2013 were retrieved. Data included maternal, perinatal and neonatal characteristics. Data were analysed for the whole population as well as for 3 GA groups.ResultsFrom 2004 to 2013, the prevalence of exclusive breast feeding decreased, in extremely preterm (GA 22–27 weeks) from 55% to 16%, in very preterm (GA 28–31 weeks) from 41% to 34% and in moderately preterm infants (GA 32–36 weeks) from 64% to 49%. The decline was statistically significant (p<0.001) in all 3 GA groups. This decline remained significant when adjustments were made for factors negatively associated with exclusive breast feedingandwhich became more prevalent during the study period, that is, small for GA (all groups) and maternal mental illness (very preterm and moderately preterm infants).ConclusionsIn the past 10 years, Sweden has experienced a lower rate of exclusive breast feeding in preterm infants, especially in extremely preterm infants. The factors analysed in this study explain only a small proportion of this decline. The decline in exclusive breast feeding at discharge from neonatal units raises concern and present challenges to the units to support and promote breast feeding.
A patient feedback reporting tool for OpenNotes: implications for patient-clinician safety and quality partnerships
Authors: Bell Sigall K , Gerard Macda , Fossa Alan , Delbanco Tom , Folcarelli Patricia H , Sands Kenneth E , Sarnoff Lee Barbara , Walker Jan 
Published: December 2016

BackgroundOpenNotes, a national movement inviting patients to read their clinicians' notes online, may enhance safety through patient-reported documentation errors.ObjectiveTo test an OpenNotes patient reporting tool focused on safety concerns.MethodsWe invited 6225 patients through a patient portal to provide note feedback in a quality improvement pilot between August 2014 and 2015. A link at the end of the note led to a 9-question survey. Patient Relations personnel vetted responses, shared safety concerns with providers and documented whether changes were made.Results2736/6225(44%) of patients read notes; among these, 1 in 12 patients used the tool, submitting 260 reports. Nearly all (96%) respondents reported understanding the note. Patients and care partners documented potential safety concerns in 23% of reports; 2% did not understand the care plan and 21% reported possible mistakes, including medications, existing health problems, something important missing from the note or current symptoms. Among these, 64% were definite or possible safety concerns on clinician review, and 57% of cases confirmed with patients resulted in a change to the record or care. The feedback tool exceeded the reporting rate of our ambulatory online clinician adverse event reporting system several-fold. After a year, 99% of patients and care partners found the tool valuable, 97% wanted it to continue, 98% reported unchanged or improved relationships with their clinician, and none of the providers in the small pilot reported worsening workflow or relationships with patients.ConclusionsPatients and care partners reported potential safety concerns in about one-quarter of reports, often resulting in a change to the record or care. Early data from an OpenNotes patient reporting tool may help engage patients as safety partners without apparent negative consequences for clinician workflow or patient-clinician relationships.
A study of correlation of angioarchitecture of intracranial blood vessels with difficulty during endovascular coiling of aneurysms
Authors: Patel Ketan , Singh Daljit , Singh Hukum , Narang Poonam , Tandon Monica , Ganjoo Pragati 
Published: December 2016

ObjectiveThe duration and complications of coiling are dependent on several factors. These include experience with the armamentarium and the expertise of the operator. Also, the angioarchitecture of the blood vessel can play an important role in the duration of the procedure and outcome.Methods41 patients underwent endovascular coiling. The angioarchitecture of the vessels in terms of the course of the blood vessels from the arch of the aorta to the aneurysm, and the angles between the arch and its branches, between the parent and feeding arteries, and between the feeding artery and the aneurysm were measured. During coiling, duration, attempts, complications, and outcome were recorded. A correlation was made between angioarchitecture and difficulty during coiling.ResultsBased on number of attempts of coiling, two groups were defined. In group I, 26 patients underwent a single attempt with a mean duration of 61 min and in group II, 15 patients had more than one attempt with a mean duration of 98 min. The mean angle between the arch and its branches, between the internal carotid artery and the anterior cerebral artery, and between the anterior communicating artery and the aneurysm was more acute in group II compared with group I. Spearman's correlation suggested that as the angle at different vessel levels decreased, duration, attempt, and complications increased, and vice versa.ConclusionsAngioarchitecture analysis revealed that the sharper the angle (acute angle) between various vessels, the greater the difficulty in negotiating a microcatheter through the vessels and the more complications, duration, number of attempts, and poor outcome. We therefore feel that angioarchitecture analysis should be done carefully in all patients in whom the decision to undergo coiling is taken.
Opercular Index Score: a CT angiography-based predictor of capillary robustness and neurological outcomes in the endovascular management of acute ischemic stroke
Authors: Copelan Alexander , Chehab Monzer , Brinjikji Waleed , Wilseck Zachary , Kallmes David F , Wilseck Jeffery 
Published: December 2016

BackgroundMany CT angiography (CTA) collateral scoring systems are either subjective or complex and time consuming.ObjectiveTo evaluate the correlation between a CTA collateral scoring system—the Opercular Index Score (OIS)—with neurological outcomes at 90 days following endovascular treatment for acute ischemic stroke (AIS) secondary to large vessel occlusion.MethodsFifty-five patients with AIS due to distal internal carotid artery, M1, or proximal M2 occlusions who underwent endovascular treatment were included. OIS was retrospectively calculated from CTA images, reconstructed from CT perfusion imaging, as the ratio of opacified M3 opercular branches in the Sylvian fissure on the unaffected side to those on the stroke side and dichotomized into favorable (OIS≤2) and poor (OIS>2). The ability of OIS to predict good neurological outcomes (modified Rankin Scale score ≤2 at 90 days) was assessed using sensitivity, specificity, and area under the curve (AUC) with receiver operating characteristic analysis.ResultsThirty-five patients had a favorable OIS and 20 patients had a poor OIS. Patients with favorable OIS had an 80.0% (n=28) rate of good neurological outcomes compared with 15.0% (n=3) of patients with a poor OIS (p<0.0001). On multivariate logistic regression analysis adjusting for baseline National Institutes of Health Stroke Scale score, OIS, and device used, favorable OIS was the only variable independently associated with good neurological outcome (OR=17.2, 95% CI 3.8 to 104.3) and demonstrated a sensitivity of 90.3% and specificity of 70.8% with an AUC of 0.822.ConclusionsOIS is a simple and practical non-invasive scoring system that can be used to predict collateral robustness and good neurological outcome among patients with AIS undergoing endovascular treatment.