bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete response and long-term survival to endocrine monotherapy in a patient with metastatic breast cancer in a low-income country: a case report
Authors: Sada Raghad , Karim Nouralhuda , Rohaibani Ghina , Alali Mousa , Saifo Maher 
Published: September 2024

Abstract
Background
Breast cancer is the most common cancer in women. Progression-free survival for hormone receptor-positive/human epidermal growth factor receptor-2-negative metastatic breast cancer treated with endocrine therapy in combination with cyclin4/6-dependent kinase is approximately 25 months. This case represents metastatic breast cancer treated with endocrine therapy, leading to long-term survival.

Case presentation
A 40-year-old Syrian woman diagnosed with hormone receptor-negative breast cancer was treated surgically with adjuvant chemotherapy and radiotherapy. She developed local and nodal recurrences that were hormone receptor-positive, followed by a recurrence of malignant pleural effusion. She was initially treated with chemotherapy and then placed on endocrine therapy with a complete response from 2014 until now. The patient also suffered from adverse events of medications, such as heart failure and osteoporosis, which were treated appropriately.

Conclusion
This case demonstrates a long-lasting complete response to metastatic breast cancer with malignant pleural effusion. This shows the validity of endocrine therapy in recurrent hormone receptor-positive breast cancer, especially in countries that cannot afford targeted therapies or genetic tests. It also highlights the necessity for a better understanding of the prognostic and predictive factors.
Knowledge, attitudes, and readiness about critical antimicrobial resistant organisms among healthcare workers at colonial war memorial hospital in Fiji: a pre and post intervention study
Authors: Buising Kirsty , Naidu Ravi , Prasad Shammi , Richards Matthew , Kumar Savneel Shivam , Lata Alvina , Datt Ashlyn , Genaro Sisilia Assisi , Ratusela Timaima , Nabose Ilisapeci , Cameron Donna , Suka Ana , Young-Sharma Tracey , Howden Benjamin P , Getahun Strobel Aneley 
Published: September 2024

Abstract
Background
Gram-negative bacteria resistant to carbapenems are also known as critical antimicrobial resistant organisms. Their emergence at Colonial War Memorial Hospital (CWMH), the largest hospital in Fiji, is a major clinical concern. This study was conducted to determine the knowledge, attitudes, and readiness of healthcare workers (HCW) at CWMH regarding management of patients with infections caused by critical antimicrobial resistant organisms.

Methods
A questionnaire was designed using a Likert scale to assess knowledge, attitudes, and readiness. Two cross-sectional studies were conducted, before and after the implementation of targeted educational activities which were informed by the pre-intervention study findings.

Results
A total of 393 and 420 HCW participated in the pre- and post-intervention studies, respectively. The majority of respondents were female (77.3%) and 18–34 years of age (67%). HCW professional roles included nurses (56.3%), doctors (31.6%), and laboratory personnel (12.2%). In the post-intervention study, significantly more HCW reported having received infection prevention and control (IPC) and antimicrobial resistance education and training (26.8% in pre to 45.5% in post intervention, p < 0.001). The majority of nurses and doctors (> 85% to ≥ 95%) were aware of how AMR organisms spread in healthcare settings and knew the IPC measures to prevent transmission of AMR infections including hand hygiene, standard and transmission-based precautions. Attitudes towards AMR were positive, with 84.2% pre intervention and 84.8% of HCW post intervention expressing their willingness to change their work environment to assist with AMR prevention. Perceived readiness to address the problem showed mixed results. Improvements in laboratory AMR surveillance data availability were noted (29.4–52.4%, p < 0001). Modest improvement in the hospital’s capacity for outbreak response (44–51.9%, p = 0.01), and treatment of AMR infections (38.9–44.4%, p = 0.01) was reported.

Conclusions
Our data revealed high levels of staff awareness and knowledge about AMR and IPC. However, readiness for outbreak response and treatment of critical AMR infections requires more attention. Improving AMR prevention and containment in CWMH will likely require sustained and multisectoral interventions with strong administrative commitment.
Efficient microservices offloading for cost optimization in diverse MEC cloud networks
Authors: Mahesar Abdul Rasheed , Li Xiaoping , Sajnani Dileep Kumar 
Published: September 2024

AbstractIn recent years, mobile applications have proliferated across domains such as E-banking, Augmented Reality, E-Transportation, and E-Healthcare. These applications are often built using microservices, an architectural style where the application is composed of independently deployable services focusing on specific functionalities. Mobile devices cannot process these microservices locally, so traditionally, cloud-based frameworks using cost-efficient Virtual Machines (VMs) and edge servers have been used to offload these tasks. However, cloud frameworks suffer from extended boot times and high transmission overhead, while edge servers have limited computational resources. To overcome these challenges, this study introduces a Microservices Container-Based Mobile Edge Cloud Computing (MCBMEC) environment and proposes an innovative framework, Optimization Task Scheduling and Computational Offloading with Cost Awareness (OTSCOCA). This framework addresses Resource Matching, Task Sequencing, and Task Scheduling to enhance server utilization, reduce service latency, and improve service bootup times. Empirical results validate the efficacy of MCBMEC and OTSCOCA, demonstrating significant improvements in server efficiency, reduced service latency, faster service bootup times, and notable cost savings. These outcomes underscore the pivotal role of these methodologies in advancing mobile edge computing applications amidst the challenges of edge server limitations and traditional cloud-based approaches.
Local earthquake monitoring with a low-cost seismic network: a case study in Nepal
Authors: Subedi Shiba , Hetényi György , Frédérick Massin , Adhikari Lok Bijaya , Michailos Konstantinos 
Published: September 2024

AbstractSeismic monitoring matters both for research and for populations living in areas of seismic hazard; however, it comes with a cost that is not fully affordable for developing countries. Compared to classical approaches with very quiet sites and high-quality instrumentation, it is therefore worth investigating low-cost seismic networks and how well they perform at detecting and characterizing seismicity. We analyze 1 year of seismic data from an educational seismology network in Nepal, create our own earthquake catalog, and compare it to the publicly available national observatory catalog. We find that despite the noisier seismic station sites, the overall results are comparable and all the main features relevant for seismicity are found. We present quantitative analyses of locations, magnitudes and their frequency distribution in our catalog, as well as differences with the observatory catalog. Differences between the two catalogs primarily stem from the respective network geometries and their coverage, as well as daytime noise level differences. We conclude that if properly planned and installed, low-cost seismic networks are a viable, feasible and significant complement to monitor seismic activity.
Graphical Abstract
Trailblazing Motivation and Marginalized Group Members: Changing Expectations to Pave the Way for Others
Authors: Knowlton Karren 
Published: September 2024

Employees from marginalized groups frequently face low performance expectations based on group membership. Although past research shows several different reactions to these types of expectations, such as stereotype threat and stereotype reactance, scholars still know little about when and why low expectations spur individuals to not only try to prove themselves, but to seek to change expectations and opportunities for others like them. Addressing this discrepancy, I introduce trailblazing motivation, which captures the desire to set new precedents that open doors for others. I integrate self-determination theory and regulatory focus theory to identify group-based low expectations, moderated by a sense of belonging with one’s broad marginalized group, and core self-evaluations as key antecedents of trailblazing motivation. I hypothesize that trailblazing motivation will lead to not only greater persistence in one’s work—as with stereotype reactance—but also potentially riskier behaviors aimed at changing expectations for one’s broad group on a larger scale, including advocacy for other marginalized group members and diversity, equity, and inclusion–related issue selling. I test and find support for these hypotheses across a time-lagged survey study and a preregistered experiment. I also establish discriminant validity for trailblazing motivation from other responses to group-based low performance expectations. This research advances our understanding of the behavior of marginalized individuals at work by helping to explain (1) when and why people facing group-based low expectations go beyond seeking to prove their own abilities and also strive to effect change for their marginalized group as a whole and (2) how a closer connection to one’s marginalized group can drive people to increase opportunities for that broad group. Funding: This research was funded by a grant from The Leadership Center at The Wharton School, University of Pennsylvania [Grant 2000-0267] as well as through Post-doctoral Fellowship research funds allocated by The Tuck School, Dartmouth College.
Paediatric trigger thumbs: patient-reported outcome measures over a minimum of ten years’ follow-up
Authors: Farr Sebastian , Mataric Teofil , Kroyer Bettina , Barik Sitanshu 
Published: September 2024

AimsThe paediatric trigger thumb is a distinct clinical entity with unique anatomical abnormalities. The aim of this study was to present the long-term outcomes of A1 pulley release in idiopathic paediatric trigger thumbs based on established patient-reported outcome measures.MethodsThis study was a cross-sectional, questionnaire-based study conducted at a tertiary care orthopaedic centre. All cases of idiopathic paediatric trigger thumbs which underwent A1 pulley release between 2004 and 2011 and had a minimum follow-up period of ten years were included in the study. The abbreviated version of the Disabilities of Arm, Shoulder and Hand questionnaire (QuickDASH) was administered as an online survey, and ipsi- and contralateral thumb motion was assessed.ResultsA total of 67 patients completed the survey, of whom 63 (94%) had full interphalangeal joint extension or hyperextension. Severe metacarpophalangeal joint hyperextension (> 40°) was documented in 15 cases (22%). The median QuickDASH score was 0 (0 to 61), indicating excellent function at a median follow-up of 15 years (10 to 19). Overall satisfaction was high, with 56 patients (84%) reporting the maximal satisfaction score of 5. Among 37 patients who underwent surgery at age ≤ two years, 34 (92%) reported the largest satisfaction, whereas this was the case for 22 of 30 patients (73%) with surgery at aged > two years (p = 0.053). Notta’s nodule resolved in 49 patients (73%) at final follow-up. No residual triggering or revision surgery was observed.ConclusionSurgical release of A1 pulley in paediatric trigger thumb is an acceptable procedure with excellent functional long-term outcomes. There was a trend towards higher satisfaction with earlier surgery among the patients.Cite this article: Bone Jt Open 2024;5(9):736–741.
A machine learning-based prediction of hospital mortality in mechanically ventilated ICU patients
Authors: Li Hexin , Ashrafi Negin , Kang Chris , Zhao Guanlan , Chen Yubing , Pishgar Maryam 
Published: September 2024

Background
Mechanical ventilation (MV) is vital for critically ill ICU patients but carries significant mortality risks. This study aims to develop a predictive model to estimate hospital mortality among MV patients, utilizing comprehensive health data to assist ICU physicians with early-stage alerts.

Methods
We developed a Machine Learning (ML) framework to predict hospital mortality in ICU patients receiving MV. Using the MIMIC-III database, we identified 25,202 eligible patients through ICD-9 codes. We employed backward elimination and the Lasso method, selecting 32 features based on clinical insights and literature. Data preprocessing included eliminating columns with over 90% missing data and using mean imputation for the remaining missing values. To address class imbalance, we used the Synthetic Minority Over-sampling Technique (SMOTE). We evaluated several ML models, including CatBoost, XGBoost, Decision Tree, Random Forest, Support Vector Machine (SVM), K-Nearest Neighbors (KNN), and Logistic Regression, using a 70/30 train-test split. The CatBoost model was chosen for its superior performance in terms of accuracy, precision, recall, F1-score, AUROC metrics, and calibration plots.

Results
The study involved a cohort of 25,202 patients on MV. The CatBoost model attained an AUROC of 0.862, an increase from an initial AUROC of 0.821, which was the best reported in the literature. It also demonstrated an accuracy of 0.789, an F1-score of 0.747, and better calibration, outperforming other models. These improvements are due to systematic feature selection and the robust gradient boosting architecture of CatBoost.

Conclusion
The preprocessing methodology significantly reduced the number of relevant features, simplifying computational processes, and identified critical features previously overlooked. Integrating these features and tuning the parameters, our model demonstrated strong generalization to unseen data. This highlights the potential of ML as a crucial tool in ICUs, enhancing resource allocation and providing more personalized interventions for MV patients.
The Poison Culture: The Forbidden Tradition, Social Class and Belief of Poisoned People in Aceh
Authors: Pohan Zulfikar Riza Hariz 
Published: September 2024

The poison in Aceh (especially in Aceh Singkil) is called Aji. Aji is a mystical tradition aiming to achieve a certain spiritual level (maqam). There are some people referred to as Pekhaji (poison makers), whom the local people are wary of. And there are certain villages forbidden for foreigners because there is fear that the poison is added to food and drink. Even if a person is accused of being a Pekhaji or a village, it is considered forbidden, and no legal action is taken because it is based only on speculation. Aji as a spiritual practice is considered taboo; the Pekhaji's and forbidden villages are socially and economically marginalized. The forbidden villages and the Pekhaji are usually aimed at the poor and disadvantaged traditional village heads; the people accused as Pekhaji are poor people who do not get proper civil rights. This research examined rituals in the Aji tradition as part of social construction and analyzed religious studies by viewing social stratification in traditional villages and local rituals. The data in this research were collected through interviews and phenomenological field observations to explain all aspects of the Aji tradition in Aceh Singkil.
How Can Artificial Intelligence Transform Asset Management?
Authors: Immenkötter Philipp 
Published: September 2024

Abstract
This article examines the transformative potential of artificial intelligence (AI) in asset management, highlighting how AI can enhance research, decision-making, communication, and trading processes. AI, particularly through machine learning (ML) and generative models, can significantly reduce analysts’ time on data collection and analysis, offer standardized recommendations, and improve communication efficiency. However, risks include potential biases and a lack of transparency in AI-driven decisions.
Applying embodied meaning of spatial prepositions and the Principled Polysemy
model to teaching English as a second language: the case of to and on
Authors: Boieblan Mostafa 
Published: September 2024

Abstract
Due to the bewildering array of spatial configurations that languages build around spatial relations, the acquisition of English spatial prepositions is a daunting task for learners of English as L2. For instance, while the embodied meanings of contact and containment are expressed in English through on and in, respectively, Spanish conveys such configurations through en (in). Furthermore, spatial prepositions bear non-geometric senses, especially those imbued with metaphorical configurations. Accordingly, in addition to its spatial configuration of motion, to, for example, may denote a metaphorical (He gave a questioning look to someone) or attachment sense (The building next to the hospital). Teaching English as L2, however, does not provide learners a conceptual guide to how these senses are related and thus does not render them amenable to systematic, enduring learning. Premised on the assumption that these senses are schematically related through the Principled Polysemy model (PPM), this study assesses whether instructing Spanish learners of English at B1 level on the usages of on and to applying this model will lead to learning benefits. Participants (n = 90) were randomized to receive instruction on the usage of such prepositions based on Collocation Approach (experimental group 1), PPM (experimental group 2), or not receive such instruction (control group). Then they completed a cloze test containing different usages of the target prepositions on three instructional conditions: pre-, post-, and delayed post-test. Differential mean scores were computed using planned contrasts, which indicates a statistically significant effect for PPM.
Beobachtungen zum trilateralen internationalen mennonitisch-lutherisch-römisch-katholischen Dialog zur Taufe (2012–2017)
Authors: Wormstädt Knut V.M. 
Published: September 2024

Zusammenfassung
Der Beitrag stellt den internationalen Dialog zur Taufe zwischen Mennonitischer Weltkonferenz, Lutherischem Weltbund und Römisch-katholischer Kirche dar. Hierbei wird das Ergebnisdokument von 2021 betrachtet und ein Überblick über die erzielten Ergebnisse und deren Charakter gegeben. Eine besondere Berücksichtigung erfährt dabei die trilaterale Struktur dieses Gesprächs, die sowohl aus der Binnensicht der Beteiligten als auch aus der Außensicht ökumenischer Forschung in den Blick geraten.
Baptism and the Process of Christian Initiation Reconsidered
Authors: Fiddes Paul 
Published: September 2024

Abstract
In ecumenical conversations between 2000 and 2010, representatives of the Baptist churches proposed that baptism should be understood as one element – though essential – in a longer process of Christian initiation. The paper recalls the reason for this proposal and then revisits it by considering its relevance to two recent issues: the rite of renewal of baptismal vows through immersion in water in Anglican churches and the “synodal pathway” in the Catholic Church.
Kirchengemeinschaft auf dem Weg
Authors: Stettner Maria 
Published: September 2024

Zusammenfassung
„Kirchengemeinschaft auf dem Weg“ ist der Terminus, mit dem VELKD und BEFG bereits bestehende Gemeinsamkeiten und weiter zu entwickelnde Gemeinschaft mit dem Ziel voller Kirchengemeinschaft beschreiben. Noch stehen Differenzen in der Taufpraxis im Weg. Als Brücke dient Paul Fiddes’ Ansatz des christlichen Initiationsprozesses mit unterschiedlich akzentuierten Elementen auf dem Weg zum Christsein, der dazu beitragen kann, die in unterschiedliche Wege zum Christsein eingebettete Taufpraxis der jeweils anderen Kirche zu respektieren.
„Kirche im Defekt“ – „Kirche im Exzess“
Authors: Hofheinz Marco 
Published: September 2024

Zusammenfassung
Karl Barths Typologie „Kirche im Defekt“ und „Kirche im Exzess“ wird im Sinne der Wittgenstein’schen Leiter angewandt, um die Herausforderungen einer postchristlichen Gesellschaft für täuferische und nichttäuferische Kirchen in den Blick zu nehmen. Täuferische Kirchen stehen angesichts des christlichen Mehrheitsverlustes hierzulande in der Gefahr der Selbstsakralisierung, während nichttäuferischen Kirchen die der Selbstsäkularisierung und Selbstbanalisierung droht. Der Artikel basiert auf einem Eingangsstatement von Marco Hofheinz zu einem Podiumsgespräch mit Fernando Enns bei der 68. Europäischen Tagung für Konfessionskunde.
Kulturelle und konfessionelle Diversität als Herausforderung für die verfassten Kirchen
Authors: Nagel Alexander-Kenneth 
Published: September 2024

Zusammenfassung
Dieser Beitrag versteht sich als erster Aufschlag zu einem engeren Dialog zwischen der theologischen Konfessionskunde und der sozialwissenschaftlichen Religionsforschung bei der Untersuchung sogenannter Migrationskirchen. Dabei sind zwei Thesen leitend: Zum einen bietet der konfessionskundliche Blick die Chance, gewisse funktionalistische Engführungen der sozialwissenschaftlichen Außenperspektive zu vermeiden und religiöse Inhalte stärker in den Fokus zu rücken. Zum anderen ist davon auszugehen, dass interkulturelle Öffnung und der Umgang mit konfessioneller Diversität aus Sicht der verfassten Kirchen strukturanaloge Herausforderungen darstellen. In beiden Fällen geht es darum, eine Balance zwischen Partikularismus und Universalismus zu finden. Dies kommt auch objektsprachlich in programmatischen Formeln wie „Gemeinsam Kirche Sein“ oder der Rede von der „versöhnten Verschiedenheit“ zum Ausdruck. Hier kann der religionssoziologische Blick auf Migrationskirchen zu einem besseren Verständnis für kulturelle und konfessionelle Grenzziehungen und -überschreitungen im alltäglichen ökumenischen Miteinander beitragen.
„Heilung der Erinnerungen – Das Verhältnis der evangelischen Frei- und Landeskirchen im 19. Jahrhundert“
Authors: Heiser Andreas 
Published: September 2024

Zusammenfassung
In dem Forschungsprozess „Heilung der Erinnerungen“ wurde von 2013 bis 2017 das Verhältnis der evangelischen Frei- und Landeskirchen in Deutschland im 19. Jahrhundert untersucht, um durch eine Vergegenwärtigung der Ausgangslage zu einem gegenseitigen Verstehen anzuleiten, Urteile der Vergangenheit zu erkennen und in Gegenwart und Zukunft zu überwinden. Der Beitrag schildert den Verlauf, die Ergebnisse und Wirkungen des Forschungsprozesses und formuliert Erträge für die weitere Forschung.
Addressing the BIPOC teacher shortage: voices of Black male teachers
Authors: Gregson Susan , Gerardo Juan , Breiner Jonathan M. 
Published: September 2024

Abstract
This case study explores the experiences of three Black male teachers who graduated from the University of Cincinnati (UC) middle childhood teacher preparation program between 2013 and 2022. While the UC School of Education strives to serve an urban mission, during this period, fewer than 2 % of teacher candidates in the middle childhood program identified as Black men. Interviews were conducted with each teacher to determine what attracted these teachers to the profession, what barriers they faced in obtaining their degree, how were they supported in the program, and what supports would have made the program more positive for them. Narratives provided by the teachers and mediated by the researchers provide both counterstories to dominant narratives about Black male teachers, and insights for supporting and systematizing the recruitment, retention, and graduation of Black male teachers to the UC BIPOC Teacher Pathway. Findings may also be useful for other teacher education programs with similar aims.