bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Calm After the Storm: A Systematic Review of Human Health Following Flood and Storm Disasters
Authors: Saulnier Dell D. , Brolin Ribacke Kim , von Schreeb Johan 
Published: June 2017

AbstractIntroductionHow the burden of disease varies during different phases after floods and after storms is essential in order to guide a medical response, but it has not been well-described. The objective of this review was to elucidate the health problems following flood and storm disasters.MethodsA literature search of the databases Medline (US National Library of Medicine, National Institutes of Health; Bethesda, Maryland USA); Cinahl (EBSCO Information Services; Ipswich, Massachusetts USA); Global Health (EBSCO Information Services; Ipswich, Massachusetts USA); Web of Science Core Collection (Thomson Reuters; New York, New York USA); Embase (Elsevier; Amsterdam, Netherlands); and PubMed (National Center for Biotechnology Information, National Institutes of Health; Bethesda, Maryland USA) was conducted in June 2015 for English-language research articles on morbidity or mortality and flood or storm disasters. Articles on mental health, interventions, and rescue or health care workers were excluded. Data were extracted from articles that met the eligibility criteria and analyzed by narrative synthesis.ResultsThe review included 113 studies. Poisonings, wounds, gastrointestinal infections, and skin or soft tissue infections all increased after storms. Gastrointestinal infections were more frequent after floods. Leptospirosis and diabetes-related complications increased after both. The majority of changes occurred within four weeks of floods or storms.ConclusionHealth changes differently after floods and after storms. There is a lack of data on the health effects of floods alone, long-term changes in health, and the strength of the association between disasters and health problems. This review highlights areas of consideration for medical response and the need for high-quality, systematic research in this area.SaulnierDD,Brolin RibackeK,von SchreebJ.No calm after the storm: a systematic review of human health following flood and storm disasters.Prehosp Disaster Med.2017;32(5):568–579.
Specialized palliative care in advanced cancer: What is the efficacy? A systematic review
Authors: Holmenlund Kristina , Sjøgren Per , Nordly Mie 
Published: June 2017

ABSTRACTObjective:Due to the multiple physical, psychological, existential, and social symptoms involved, patients with advanced cancer often have a reduced quality of life (QoL), which requires specialized palliative care (SPC) interventions. The primary objective of the present systematic review was to review the existing literature about SPC and its effect on QoL, on physical and psychological symptoms, and on survival in adult patients with advanced cancer.Method:We utilized a search strategy based on the PICO (problem/population, intervention, comparison, and outcome) framework and employed terminology related to cancer, QoL, symptoms, mood, and palliative care. The search was performed in Embase, PubMed, and the Cochrane Central Register of Controlled Trials. Selected studies were analyzed and categorized according to methods, results, quality of evidence, and strength of recommendation.Results:Six randomized controlled trials (RCTs) were selected for analysis (out of a total of 1,115 studies). Two other studies were found by hand search, one of which was only published in conference abstract form. The RCTs differed in terms of aims, interventions, control groups, and outcomes; however, the primary aim of all of them was to investigate the effect of SPC on patient QoL. Five studies found improved QoL in the intervention group. Physical symptom intensity decreased in two studies, and three studies found improved mood in the intervention group. However, physical and psychological symptoms were secondary outcomes in these studies. Survival was improved in two studies. All the studies offered generalizability, but the level of evidence validity varied among them.Significance of results:Due to several methodological limitations, the evidence offered in these studies ranged from low to high. The evidence in this field of study in general is still nascent, but there is growing support for the utilization of SPC to improve the quality of life of adult patients with advanced cancer. The evidence that SPC reduces physical and psychological symptoms is moderate, while the evidence that it prolongs survival is low.
Institutions and place: bringing context back into the study of the resource curse
Authors: ORIHUELA JOSÉ CARLOS 
Published: June 2017

AbstractScholars across the social sciences have debated whether resource dependence curses or blesses national development prospects, with a growing consensus on mixed outcomes and the centrality of institutions. Mainstream literature, however, falls short in depicting what the resource curse entails: the claim that “institutions matter” usually has a narrow meaning that largely overlooks the significance of place. A review of the paved road in research reveals a need to critically integrate approaches to studying the curse, as well as more insightful research onwhichinstitutions matter,how, andwhere. Expounding six governance challenges and thirteen development traps, I set out a simple yet crucial lesson: resource-based development presents both blessings and curses for any given resource-rich country in any given time period, and institutions are likely to be part of the explanation. I sketch how a “context matters” framework could guide future research, with illustrations from the Latin American experience.
Antenatal depressed mood and child cognitive and physical growth at 18-months in South Africa: a cluster randomised controlled trial of home visiting by community health workers
Authors: Tomlinson M. , Rotheram-Borus M. J. , Scheffler A. , le Roux I. 
Published: June 2017

Aim.To examine the child outcomes at 18-months post-birth of a population cohort of women with antenatal depressed mood, half of whom were randomly chosen to receive perinatal home visits from community health workers during pregnancy.Method.Pregnant women in 24 neighbourhoods (98% participation) were randomised by neighbourhood to: (1) standard clinic care (SC; 12 neighbourhoods;n= 594) or (2) the Philani Intervention Program, a home visiting intervention plus standard care (12 neighbourhoods;n= 644). The physical and cognitive outcomes of children of mothers with antenatally depressed mood (Edinburg Perinatal Depression Scale >13) in the intervention condition were compared at 18-months post-birth to children of mothers without depressed mood in pregnancy in both conditions.Results.More than a third of mothers had heightened levels of antenatal depressed mood (35%), similar across conditions. Antenatal depressed mood was significantly associated with being a mother living with HIV, using alcohol and food insecurity. At 18-months, the overall cognitive and motor scale scores on the Bayley Scales of Development were similar. However, 10.3% fewer children of mothers with antenatal depressed mood in the intervention condition had cognitive scores on the Bayley Scales that were less than 85 (i.e.,s.d.= 2 lower than normal) compared with children of mothers with antenatal depressed mood in the SC condition. Intervention children of mothers with antenatal depressed mood were also significantly less likely to be undernourished (Weight-for-Age Z-scores < −2).Conclusion.Cognitive development and child growth among children born to mothers with antenatal depressed mood can be improved by mentor mother home visitors, probably resulting from better parenting and care received early in life.
Experimental evidence of Willis coupling in a one-dimensional effective material element
Authors: Muhlestein Michael B. , Sieck Caleb F. , Wilson Preston S. , Haberman Michael R. 
Published: June 2017

AbstractThe primary objective of acoustic metamaterial research is to design subwavelength systems that behave as effective materials with novel acoustical properties. One such property couples the stress–strain and the momentum–velocity relations. This response is analogous to bianisotropy in electromagnetism, is absent from common materials, and is often referred to as Willis coupling after J.R., Willis, who first described it in the context of the dynamic response of heterogeneous elastic media. This work presents two principal results: first, experimental and theoretical demonstrations, illustrating that Willis properties are required to obtain physically meaningful effective material properties resulting solely from local behaviour of an asymmetric one-dimensional isolated element and, second, an experimental procedure to extract the effective material properties from a one-dimensional isolated element. The measured material properties are in very good agreement with theoretical predictions and thus provide improved understanding of the physical mechanisms leading to Willis coupling in acoustic metamaterials.
Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates
Authors: Schäfer Philipp , Palacin Thomas , Sidera Mireia , Fletcher Stephen P. 
Published: June 2017

AbstractUsing asymmetric catalysis to simultaneously form carbon–carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely applicable enantioselective Suzuki-Miyaura variations to provide 3D molecules remain elusive. Here we report a rhodium-catalysed asymmetric Suzuki-Miyaura reaction with important partners including aryls, vinyls, heteroaromatics and heterocycles. The method can be used to couple two heterocyclic species so the highly enantioenriched products have a wide array of cores. We show that pyridine boronic acids are unsuitable, but they can be halogen-modified at the 2-position to undergo reaction, and this halogen can then be removed or used to facilitate further reactions. The method is used to synthesize isoanabasine, preclamol, and niraparib—an anticancer agent in several clinical trials. We anticipate this method will be a useful tool in drug synthesis and discovery.
Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
Authors: Patwardhan Anand , Bardin Sabine , Miserey-Lenkei Stéphanie , Larue Lionel , Goud Bruno , Raposo Graça , Delevoye Cédric 
Published: June 2017

AbstractExocytic carriers convey neo-synthesized components from the Golgi apparatus to the cell surface. While the release and anterograde movement of Golgi-derived vesicles require the small GTPase RAB6, its effector ELKS promotes the targeting and docking of secretory vesicles to particular areas of the plasma membrane. Here, we show that specialized cell types exploit and divert the secretory pathway towards lysosome related organelles. In cultured melanocytes, the secretory route relies on RAB6 and ELKS to directly transport and dock Golgi-derived carriers to melanosomes. By delivering specific cargos, such as MART-1 and TYRP2/ DCT, the RAB6/ELKS-dependent secretory pathway controls the formation and maturation of melanosomes but also pigment synthesis. In addition, pigmentation defects are observed in RAB6 KO mice. Our data together reveal for the first time that the secretory pathway can be directed towards intracellular organelles of endosomal origin to ensure their biogenesis and function.
Analytical solutions of the radiative transport equation for turbid and fluorescent layered media
Authors: Liemert André , Reitzle Dominik , Kienle Alwin 
Published: June 2017

AbstractAccurate and efficient solutions of the three dimensional radiative transport equation were derived in all domains for the case of layered scattering media. Index mismatched boundary conditions based on Fresnel’s equations were implemented. Arbitrary rotationally symmetric phase functions can be applied to characterize the scattering in the turbid media. Solutions were derived for an obliquely incident beam having arbitrary spatial profiles. The derived solutions were successfully validated with Monte Carlo simulations and partly compared with analytical solutions of the diffusion equation.
Multicolor two-photon imaging of endogenous fluorophores in living tissues by wavelength mixing
Authors: Stringari Chiara , Abdeladim Lamiae , Malkinson Guy , Mahou Pierre , Solinas Xavier , Lamarre Isabelle , Brizion Sébastien , Galey Jean-Baptiste , Supatto Willy , Legouis Renaud , Pena Ana-Maria , Beaurepaire Emmanuel 
Published: June 2017

AbstractTwo-photon imaging of endogenous fluorescence can provide physiological and metabolic information from intact tissues. However, simultaneous imaging of multiple intrinsic fluorophores, such as nicotinamide adenine dinucleotide(phosphate) (NAD(P)H), flavin adenine dinucleotide (FAD) and retinoids in living systems is generally hampered by sequential multi-wavelength excitation resulting in motion artifacts. Here, we report on efficient and simultaneous multicolor two-photon excitation of endogenous fluorophores with absorption spectra spanning the 750–1040 nm range, using wavelength mixing. By using two synchronized pulse trains at 760 and 1041 nm, an additional equivalent two-photon excitation wavelength at 879 nm is generated, and achieves simultaneous excitation of blue, green and red intrinsic fluorophores. This method permits an efficient simultaneous imaging of the metabolic coenzymes NADH and FAD to be implemented with perfect image co-registration, overcoming the difficulties associated with differences in absorption spectra and disparity in concentration. We demonstrate ratiometric redox imaging free of motion artifacts and simultaneous two-photon fluorescence lifetime imaging (FLIM) of NADH and FAD in living tissues. The lifetime gradients of NADH and FAD associated with different cellular metabolic and differentiation states in reconstructed human skin and in the germline of live C. Elegans are thus simultaneously measured. Finally, we present multicolor imaging of endogenous fluorophores and second harmonic generation (SHG) signals during the early stages of Zebrafish embryo development, evidencing fluorescence spectral changes associated with development.
Modelling the effects of global climate change on Chikungunya transmission in the 21st century
Authors: Tjaden Nils B. , Suk Jonathan E. , Fischer Dominik , Thomas Stephanie M. , Beierkuhnlein Carl , Semenza Jan C. 
Published: June 2017

AbstractThe arrival and rapid spread of the mosquito-borne viral disease Chikungunya across the Americas is one of the most significant public health developments of recent years, preceding and mirroring the subsequent spread of Zika. Globalization in trade and travel can lead to the importation of these viruses, but climatic conditions strongly affect the efficiency of transmission in local settings. In order to direct preparedness for future outbreaks, it is necessary to anticipate global regions that could become suitable for Chikungunya transmission. Here, we present global correlative niche models for autochthonous Chikungunya transmission. These models were used as the basis for projections under the representative concentration pathway (RCP) 4.5 and 8.5 climate change scenarios. In a further step, hazard maps, which account for population densities, were produced. The baseline models successfully delineate current areas of active Chikungunya transmission. Projections under the RCP 4.5 and 8.5 scenarios suggest the likelihood of expansion of transmission-suitable areas in many parts of the world, including China, sub-Saharan Africa, South America, the United States and continental Europe. The models presented here can be used to inform public health preparedness planning in a highly interconnected world.
Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD
Authors: Zhang Bing , Guo Fei , Ma Yuqin , Song Yingcai , Lin Rong , Shen Fu-Yi , Jin Guo-Zhang , Li Yang , Liu Zhi-Qiang 
Published: June 2017

AbstractMajor depressive disorder (MDD) is a common neuropsychiatric disorder characterized by diverse symptoms. Although several antidepressants can influence dopamine system in the medial prefrontal cortex (mPFC), but the role of D1R or D2R subtypes of dopamine receptor during anti-depression process is still vague in PFC region. To address this question, we investigate the antidepressant effect of levo-stepholidine (l-SPD), an antipsychotic medication with unique pharmacological profile of D1R agonism and D2R antagonism, and clarified its molecular mechanisms in the mPFC. Our results showed that l-SPD exerted antidepressant-like effects on the Sprague-Dawley rat CMS model of depression. Mechanism studies revealed that l-SPD worked as a specific D1R agonist, rather than D2 antagonist, to activate downstream signaling of PKA/mTOR pathway, which resulted in increasing synaptogenesis-related proteins, such as PSD 95 and synapsin I. In addition, l-SPD triggered long-term synaptic potentiation (LTP) in the mPFC, which was blocked by the inhibition of D1R, PKA, and mTOR, supporting that selective activation of D1R enhanced excitatory synaptic transduction in PFC. Our findings suggest a critical role of D1R/PKA/mTOR signaling cascade in the mPFC during the l-SPD mediated antidepressant process, which may also provide new insights into the role of mesocortical dopaminergic system in antidepressant effects.
Myocardial Deformation in Cardiac Amyloid Light-chain Amyloidosis: Assessed with 3T Cardiovascular Magnetic Resonance Feature Tracking
Authors: Li Rui , Yang Zhi-gang , Xu Hua-yan , Shi Ke , Liu Xi , Diao Kai-yue , Guo Ying-kun 
Published: June 2017

AbstractClinically, assessment of myocardial function is essential in patients with amyloid light-chain cardiac amyloidosis (AL-CA) to predict outcome and determine therapeutic approach. The aim of this study was to investigate the feasibility of cardiovascular magnetic resonance (CMR)-derived feature tracking algorithm for assessing left ventricular (LV) myocardial deformation in AL-CA, and to determine if these abnormal myocardial deformation parameters are correlated to impaired LV myocardial microvascular dysfunction. A total of 42 AL-CA patients, including 26 with preserved systolic function and 16 with impaired LVEF, and 35 healthy controls were enrolled and underwent CMR examination. Our result indicated that AL-CA patients had significantly reduced global peak strain (PS) (longitudinal, circumferential, and radial) (all P < 0.05). AL-CA patients with normal LVEF showed preserved longitudinal PS at apical and significantly reduced longitudinal PS at mid and basal segments. By Spearman’s rank correlation analysis, the LV regional radial, circumferential, and longitudinal myocardial deformation values were correlated to myocardial upslope and MaxSI in CA, regardless of LVEF. This study indicated that the abnormal LV myocardial deformation of AL-CA patients can be monitored using feature tracking CMR, even in those with preserved LVEF; and the myocardial deformation was associated with coronary microvascular dysfunction.
HCF-1 encoded by baculovirus AcMNPV is required for productive nucleopolyhedrovirus infection of non-permissive Tn368 cells
Authors: Tachibana Ami , Hamajima Rina , Tomizaki Moe , Kondo Takuya , Nanba Yoshie , Kobayashi Michihiro , Yamada Hayato , Ikeda Motoko 
Published: June 2017

AbstractBaculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) replicates in both Spodoptera frugiperda Sf21 and Trichoplusia ni Tn368 cells, whereas AcMNPV defective in hcf-1 (host cell-factor 1) gene productively infects only Sf21 cells, indicating that HCF-1 is indispensable for the AcMNPV productive infection of Tn368 cells. Here, we demonstrated that HCF-1 protein transiently expressed in Tn368 cells promotes the DNA synthesis of Hyphantria cunea MNPV ﻿(HycuMNPV), Orygia pseudotsugata MNPV and Bombyx mori NPV, which are normally unable to replicate in Tn368 cells. We also demonstrated that a recombinant HycuMNPV harboring the hcf-1 gene successfully replicates in Tn368 cells, generating substantial yields of progeny viruses and polyhedra. These results indicate that HCF-1 encoded by AcMNPV is an essential viral factor for productive NPV infection of Tn368 cells. Taken together with the previous findings on HRF-1 (host range factor 1), the present results provide strong evidence that viral genes acquired through horizontal gene transfer play an important role in baculovirus evolution, serving to expand the host range of baculoviruses.
Candidatus Mycoplasma girerdii replicates, diversifies, and co-occurs with Trichomonas vaginalis in the oral cavity of a premature infant
Authors: Costello Elizabeth K. , Sun Christine L. , Carlisle Erica M. , Morowitz Michael J. , Banfield Jillian F. , Relman David A. 
Published: June 2017

AbstractGenital mycoplasmas, which can be vertically transmitted, have been implicated in preterm birth, neonatal infections, and chronic lung disease of prematurity. Our prior work uncovered 16S rRNA genes belonging to a novel, as-yet-uncultivated mycoplasma (lineage ‘Mnola’) in the oral cavity of a premature neonate. Here, we characterize the organism’s associated community, growth status, metabolic potential, and population diversity. Sequencing of genomic DNA from the infant’s saliva yielded 1.44 Gbp of high-quality, non-human read data, from which we recovered three essentially complete (including ‘Mnola’) and three partial draft genomes (including Trichomonas vaginalis). The completed 629,409-bp ‘Mnola’ genome (Candidatus Mycoplasma girerdii str. UC-B3) was distinct at the strain level from its closest relative, vaginally-derived Ca. M. girerdii str. VCU-M1, which is also associated with T. vaginalis. Replication rate measurements indicated growth of str. UC-B3 within the infant. Genes encoding surface-associated proteins and restriction-modification systems were especially diverse within and between strains. In UC-B3, the population genetic underpinnings of phase variable expression were evident in vivo. Unique among mycoplasmas, Ca. M. girerdii encodes pyruvate-ferredoxin oxidoreductase and may be sensitive to metronidazole. This study reveals a metabolically unique mycoplasma colonizing a premature neonate, and establishes the value of genome-resolved metagenomics in tracking phase variation.
Minimal control power of controlled dense coding and genuine tripartite entanglement
Authors: Oh Changhun , Kim Hoyong , Jeong Kabgyun , Jeong Hyunseok 
Published: June 2017

AbstractWe investigate minimal control power (MCP) for controlled dense coding defined by the channel capacity. We obtain MCPs for extended three-qubit Greenberger-Horne-Zeilinger (GHZ) states and generalized three-qubit W states. Among those GHZ states, the standard GHZ state is found to maximize the MCP and so does the standard W state among the W-type states. We find the lower and upper bounds of the MCP and show for pure states that the lower bound, zero, is achieved if and only if the three-qubit state is biseparable or fully separable. The upper bound is achieved only for the standard GHZ state. Since the MCP is nonzero only when three-qubit entanglement exists, this quantity may be a good candidate to measure the degree of genuine tripartite entanglement.