bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSF-1R–Dependent Lethal Hepatotoxicity When Agonistic CD40 Antibody Is Given before but Not after Chemotherapy
Authors: Byrne Katelyn T. , Leisenring Nathan H. , Bajor David L. , Vonderheide Robert H. 
Published: May 2016

Abstract
Cancer immunotherapies are increasingly effective in the clinic, especially immune checkpoint blockade delivered to patients who have T cell–infiltrated tumors. Agonistic CD40 mAb promotes stromal degradation and, in combination with chemotherapy, drives T cell infiltration and de novo responses against tumors, rendering resistant tumors susceptible to current immunotherapies. Partnering anti-CD40 with different treatments is an attractive approach for the next phase of cancer immunotherapies, with a number of clinical trials using anti-CD40 combinations ongoing, but the optimal therapeutic regimens with anti-CD40 are not well understood. Pancreatic ductal adenocarcinoma (PDA) is classically resistant to immunotherapy and lacks baseline T cell infiltration. In this study, we used a tumor cell line derived from a genetically engineered mouse model of PDA to investigate alterations in the sequence of anti-CD40 and chemotherapy as an approach to enhance pharmacological delivery of chemotherapy. Unexpectedly, despite our previous studies showing anti-CD40 treatment after chemotherapy is safe in both mice and patients with PDA, we report in this article that anti-CD40 administration &lt;3 d in advance of chemotherapy is lethal in more than half of treated C57BL/6 mice. Anti-CD40 treatment 2 or 3 d before chemotherapy resulted in significantly increased populations of both activated myeloid cells and macrophages and lethal hepatotoxicity. Liver damage was fully abrogated when macrophage activation was blocked using anti–CSF-1R mAb. These studies highlight the dual nature of CD40 in activating both macrophages and T cell responses, and the need for preclinical investigation of optimal anti-CD40 treatment regimens for safe design of clinical trials.
Extended Occupational Therapy Reintegration Strategies for a Woman With Guillain-Barré Syndrome: Case Report
Authors: Tomita Machiko R. , Buckner Kathryn , Saharan Sumandeep , Persons Kimberley , Liao Sheng Hui 
Published: May 2016

Abstract
This case report describes a unique long-term functional recovery process to promote successful community reintegration for a woman with Guillain-Barré syndrome (GBS), a rare autoimmune disease. Her main symptoms were very limited mobility and depressive symptoms due to the unknown cause of and cure for the illness. Holistic occupational strategies helped the client stabilize her emotional state, create a safe home environment, improve a communication method, increase physical activity, and promote social participation. Participation in a fall prevention clinical trial lowered her risk of falling; at 9 mo, she reached 75% of the maximum Social Integration score; at 13 mo, she reached near-normal level for activities of daily living (ADLs) and her fastest time for the Timed Up and Go test; and at 2 yr, she achieved a 100% score in instrumental ADLs. For community integration of clients with GBS, a comprehensive strategic self-management approach should be prescribed for long-term recovery.
Synergy between middle infrared and millimeter-wave limb sounding of atmospheric temperature and minor constituents
Authors: Cortesi Ugo , Del Bianco Samuele , Ceccherini Simone , Gai Marco , Dinelli Bianca Maria , Castelli Elisa , Oelhaf Hermann , Woiwode Wolfgang , Höpfner Michael , Gerber Daniel 
Published: May 2016

Abstract. Synergistic exploitation of redundant and complementary information from independent observations of the same target remains a major issue in atmospheric remote sounding and increasing attention is devoted to investigate optimized or innovative methods for the combination of two or more measured data sets. This paper focuses on the synergy between middle infrared and millimeter-wave limb sounding measurements of atmospheric composition and temperature and reports the results of a study conducted as part of the preparatory activities of the PREMIER (Process Exploration through Measurements of Infrared and millimeter-wave Emitted Radiation) mission candidate to the Core Missions of the European Space Agency (ESA) Earth Explorer 7. The activity was based on data acquired by the MIPAS-STR (Michelson Interferometer for Passive Atmospheric Sounding – STRatospheric aircraft) and MARSCHALS (Millimetre-wave Airborne Receivers for Spectroscopic CHaracterisation in Atmospheric Limb Sounding) instruments on-board the high-altitude research aircraft M-55 Geophysica during the flight of the PremierEx (PREMIER Experiment) campaign on 10 March 2010 from Kiruna, Sweden, for observation of the Arctic upper troposphere and lower stratosphere. The cloud coverage observed along the flight provided representative test cases to evaluate the synergy in three different scenarios: low clouds in the first part, no clouds in the central part and high tropospheric clouds at the end. The calculation of synergistic profiles of four atmospheric targets (i.e., O3, HNO3, H2O and temperature) was performed using a posteriori combination of individual retrieved profiles, i.e., Level 2 (L2) data rather than simultaneous inversion of observed radiances, i.e., Level 1 (L1) data. An innovative method of data fusion, based on the Measurement Space Solution (MSS) was applied along with the standard approach of inversion of MARSCHALS spectral radiances using MIPAS-STR retrieval products as a priori information (L1 + L2 method). A quantitative estimate and cross-check of the results of MSS data fusion and (L1 + L2) method was achieved based on a specific set of quantifiers including the total retrieval error, the number of degrees of freedom, the relative information distribution and the synergy factor.
The Prevalence of Amblyopia, Strabismus, and Ptosis in Schoolchildren of Dezful
Authors: Yekta Abbasali , Hashemi Hassan , Norouzirad Reza , Ostadimoghaddam Hadi , Nabovati Payam , Dadbin Nooshin , Nirouzad Fereidon , Shir-Alivand Ehsan , Khabazkhoob Mehdi 
Published: May 2016

Purpose To determine the prevalence of amblyopia, strabismus, and ptosis among schoolchildren in Dezful in the west of Iran. Methods In this cross-sectional study, 1,375 schoolchildren of Dezful were selected through multistage cluster sampling. After obtaining written consents, participants had uncorrected and corrected visual acuity tests, cycloplegic refraction, and the cover test, and were examined for ptosis at the school site. Results Of the 1,151 study participants (83.7%), examinations were completed for 1,130 schoolchildren. Prevalence rates of amblyopia, strabismus, and ptosis were 2.7% (95% confidence interval [CI] 0.8-4.7), 1.9% (95% CI: 0.2-3.8), and 0.8%, respectively. Anisometropia was the most common cause of amblyopia; 45.2% of cases had anisometropic amblyopia. Among cases with strabismus, 63.6% were exotropic and 36.4% were esotropic. Conclusion The present study indicated that the prevalence of amblyopia and strabismus in Dezful schoolchildren falls in the average range. Since the Amblyopia Screening Program has been running for years, we expected lower rates compared to previous years, but this was not observed. Correcting refractive errors can significantly reduce amblyopic cases.
Comparison of Macular Findings due to Vitreomacular Traction Alone or in Association with Epiretinal Membrane
Authors: Chatziralli Irini , Theodossiadis George , Grigoropoulos Vlassis , Datseris Ioannis , Chatzirallis Alexandros , Theodossiadis Panagiotis 
Published: May 2016

Purpose To evaluate the anatomical and functional findings in patients with vitreomacular traction (VMT) alone or in combination with epiretinal membrane (ERM). Methods In this retrospective, cross-sectional study, we studied 102 patients with VMT, either alone (n = 37) or combined with ERM (n = 65). All patients were examined with spectral-domain optical coherence tomography (SD-OCT). We recorded the vitreofoveal angle of VMT nasally and temporally, the horizontal diameter of VMT, macular thickness, the presence, type, and location of macular edema, the ellipsoid zone (ΕΖ)/external limiting membrane (ELM) status, and the visual acuity. Results Patients with VMT combined with ERM presented smaller vitreofoveal angle nasally and temporally, broader adhesion diameter, and a greater extent of EZ defect compared to patients with VMT alone, although there was no statistically significant difference in EZ and ELM condition regarding the number of affected cases. There is also no statistically significant difference between the 2 groups concerning the visual acuity. In the majority of patients with VMT alone, cystoid macular edema was present mainly at the foveal area. In cases where VMT coexisted with ERM, macular edema was mostly found to be diffuse, while cystoid or mixed type, extending to the whole macular area, was also present. Conclusions Patients with VMT in association with ERM have different characteristics in SD-OCT compared to those with VMT alone regarding the type and location of macular edema, the extent of EZ defect, as well as the vitreofoveal angle and the VMT diameter. Moreover, they presented worse visual acuity compared to those with VMT alone, although the difference did not reach statistical significance.
Role of Difucosylated Lewis Y Antigen in Outcome of Locally Advanced Cervical Squamous Cell Carcinoma Treated with Cisplatin Regimen
Authors: Leone Julieta , Perez Juan E. , Dominguez Maria E. , Iturbe Julian , Leone José P. , Mac Donnell Maria C. , Grosman Gabriel , Vallejo Carlos T. , Leone Bernardo A. , Zwenger Ariel O. 
Published: May 2016

Background Several mechanisms are involved in the development of resistance to therapy in locally advanced cervical squamous cell carcinoma (LACSCC). Studies have shown that CD44 and Lewis Y antigen (LeY) form a complex that is associated with chemoresistance, tumor invasion and metastasis. We assessed the role of CD44 and LeY in the outcome of LACSCC patients treated with different chemotherapy regimens. Methods 126 LACSCC patients at FIGO stages IIB-IVA were selected from the GOCS database: 74 patients included in 3 different prospective phase II trials in the neoadjuvant setting (vinorelbine, docetaxel, ifosfamide-vinorelbine-cisplatin) and 52 patients treated with standard radiochemotherapy based on cisplatin (RCBC). Clinical data at baseline, disease-free survival (DFS) and overall survival (OS) were recorded. Univariate and multivariate Cox models were employed. Results Median age was 45.6 years (range: 24.9-80.5). Sixty-three and 47 tumors were CD44+ and LeY+, respectively. Tumors with expansive growth showed higher grade (p = 0.0024), mitotic index (p = 0.0505), tumor necrosis (p = 0.0191), LeY+ (p = 0.0034) and CD44+/LeY+ coexpression (p = 0.0334). CD44+ cells were present in 91.3% of patients with local recurrence (p = 0.0317). Advanced stage was associated with LeY+ tumors. Patients treated with RCBC had worse DFS and OS when their tumors expressed LeY (p = 0.0083 and p = 0.0137, respectively). Pre-treatment hemoglobin level, FIGO stage and tumor response remained the most significant prognostic factors in Cox regression. Conclusions In our cohort of LACSCC patients, the coexpression of CD44 and LeY was not associated with worse outcome. However, in the subgroup of patients receiving RCBC, LeY expression was correlated with shorter DFS and OS.
Threatening Men’s Mate Value Influences Aggression Toward an Intrasexual Rival: The Moderating Role of Narcissism
Authors: Bird Brian M. , Carré Justin M. , Knack Jennifer M. , Arnocky Steven 
Published: May 2016

Abstract
Correlational research has linked low mate value (MV)--one’s worth as a mating partner to members of the opposite sex--with aggression in men. In 2 experiments, we examined the effects of self-perceived MV on men’s reported willingness to aggress directly toward a hypothetical mate poacher (Experiment 1, N = 60) and observable aggression toward a same-sex rival in a laboratory paradigm (Experiment 2, N = 54). In both experiments, the roles of narcissism in moderating the effect of MV condition on subsequent aggression were examined. Results of Experiment 1 indicated that men randomly assigned to the low MV condition were significantly more willing to report aggressive intention than men in the high MV condition. This relationship was moderated by narcissism such that men in the low MV condition who were also high in narcissism were the most likely to aggress. Results of Experiment 2 similarly showed that men in the low MV condition relative to the high MV condition aggressed more toward a same-sex rival when they were high in narcissism. These findings support evolutionary hypotheses surrounding the importance of self-perceived MV in directing aggressive mating efforts, as situated in the framework of threatened egotism.
MÉTODO ALTERNATIVO PARA A DETERMINAÇÃO DO LIMITE DE CONTRAÇÃO A PARTIR DE PASTILHA PARAFINADA EM UM ARGISSOLO VERMELHO DISTRÓFICO ARÊNICO
Authors: Aita Rômulo Aragonês , Facco Ronaldo , Werlang Arthur Piccolo , Werlang Mauro Kumpfer 
Published: May 2016

O limite entre os estados semi-sólido e sólido numa amostra de solo é o limite de contração. A umidade que determina o limite inferior da zona de friabilidade do solo é obtida a partir da determinação do limite de contração. Para essa determinação, a metodologia clássica utiliza mercúrio. Esse metal pode acarretar efeitos adversos, tanto para o meio ambiente como para a saúde humana. Nesse sentido, o método da pastilha parafinada pode constituir-se numa alternativa para a determinação do limite de contração sem a necessidade do uso de mercúrio. Assim, o objetivo deste estudo foi a determinação e a comparação dos resultados obtidos para o limite de contração com a utilização de mercúrio e, sem o uso de mercúrio, mas com a utilização de parafina. Utilizaram-se quatro amostras de solo de um Argissolo Vermelho Distrófico arênico respectivamente aos horizontes diagnósticos A, E e Bt. Os valores dos limites de contração foram obtidos utilizando-se o método deslocamento de mercúrio e o método da pastilha parafinada, com oito repetições para cada amostra. Os resultados obtidos para os limites de contração determinados utilizando-se as duas metodologias mostraram baixos valores de desvio-padrão. O teste de hipóteses para amostras independentes mostrou que não houve variação significativa a um valor-p de 0,20. Adotando-se o nível de significância a partir de 10% entre os valores do limite de contração determinado pelo método proposto pela MB-55 (ABNT, 1948) e o método com a pastilha parafinada, para os horizontes diagnósticos em análise, as médias diferiram. Palavras-chave: limite de contração, zona de friabilidade do solo, método de determinação. DOI: 10.5902/2236499415712
Concise Review: Pancreatic Cancer and Bone Marrow-Derived Stem Cells
Authors: Błogowski Wojciech , Bodnarczuk Tomasz , Starzyńska Teresa 
Published: May 2016

Abstract

Pancreatic adenocarcinoma remains one of the most challenging diseases of modern gastroenterology, and, even though considerable effort has been put into understanding its pathogenesis, the exact molecular mechanisms underlying the development and/or systemic progression of this malignancy still remain unclear. Recently, much attention has been paid to the potential role of bone marrow-derived stem cells (BMSCs) in this malignancy. Hence, herein, we comprehensively review the most recent discoveries and current achievements and concepts in this field. Specifically, we discuss the significance of identifying pancreatic cancer stem cells and novel therapeutic approaches involving molecular interference of their metabolism. We also describe advances in the current understanding of the biochemical and molecular mechanisms responsible for BMSC mobilization during pancreatic cancer development and systemic spread. Finally, we summarize experimental, translational, and/or clinical evidence regarding the contribution of bone marrow-derived mesenchymal stem cells, endothelial progenitor cells, hematopoietic stem/progenitor cells, and pancreatic stellate cells in pancreatic cancer development/progression. We also present their potential therapeutic value for the treatment of this deadly malignancy in humans.

Significance
Different bone marrow-derived stem cell populations contribute to the development and/or progression of pancreatic cancer, and they might also be a promising “weapon” that can be used for anticancer treatments in humans. Even though the exact role of these stem cells in pancreatic cancer development and/or progression in humans still remains unclear, this concept continues to drive a completely novel scientific avenue in pancreatic cancer research and gives rise to innovative ideas regarding novel therapeutic modalities that can be safely offered to patients.
InGaN laser diode with metal-free laser ridge using n+-GaN contact layers
Authors: Malinverni Marco , Tardy Camille , Rossetti Marco , Castiglia Antonino , Duelk Marcus , Vélez Christian , Martin Denis , Grandjean Nicolas 
Published: May 2016

Abstract
We report on InGaN edge emitting laser diodes with a top metal electrode located beside the laser ridge. Current spreading over the ridge is achieved via a highly doped n+-type GaN layer deposited on top of the structure. The low sheet resistance of the n+-GaN layer ensures excellent lateral current spreading, while carrier injection is confined all along the ridge thanks to current tunneling at the interface between the n+-GaN top layer and the p++-GaN layer. Continuous-wave lasing at 400 nm with an output power of 100 mW is demonstrated on uncoated facet devices with a threshold current density of 2.4 kA·cm−2.
Effects of electrolyte gating on photoluminescence spectra of large-area WSe2 monolayer films
Authors: Matsuki Keiichiro , Pu Jiang , Kozawa Daichi , Matsuda Kazunari , Li Lain-Jong , Takenobu Taishi 
Published: May 2016

Abstract
We fabricated electric double-layer transistors comprising large-area WSe2 monolayers and investigated the effects of electrolyte gating on their photoluminescence (PL) spectra. Using the efficient gating effects of electric double layers, we succeeded in the application of a large electric field (∼107 V cm−1) and the accumulation of high carrier density (>1013 cm−2). As a result, we observed PL spectra based on both positively and negatively charged excitons and their gate-voltage-dependent redshifts, suggesting the effects of both an electric field and charge accumulation.
Effect of plasma jet diameter on the efficiency of reactive oxygen and nitrogen species generation in water
Authors: Oh Jun-Seok , Kakuta Maito , Furuta Hiroshi , Akatsuka Hiroshi , Hatta Akimitsu 
Published: May 2016

Abstract
The plasma jet generation of reactive oxygen and nitrogen species (RONS) in solution is important in biology, medicine, and disinfection. Studies using a wide variety of plasma jet devices have been carried out for this purpose, making it difficult to compare the performance between devices. In this study, we compared the efficiency of RONS generation in deionized (DI) water between 3.7-mm- and 800-µm-sized helium (He) plasma jets (hereafter mm-jet and µm-jet, respectively) at different treatment distances and times. The efficiency of RONS generation was determined by considering the total amount of RONS generated in DI water with respect to the input energy and gas consumption. We found that the mm-jet generated 20% more RONS in the DI water than the µm-jet at the optimized distance. However, when the input power and He gas consumption were taken into account, we discovered that the µm-jet was 5 times more efficient in generating RONS in the DI water. Under the parameters investigated in this study, the concentration of RONS continued to increase as a function of treatment time (up to 30 min). However treatment distance had a marked effect on the efficiency of RONS generation: treatment distances of 25 and 30 mm were optimal for the mm-jet and µm-jet, respectively. Our method of comparing the efficiency of RONS generation in solution between plasma jets could be used as a reference protocol for the development of efficient plasma jet sources for use in medicine, biology, and agriculture.
Tsunami source uncertainty estimation: The 2011 Japan tsunami
Authors: Dettmer Jan , Hawkins Rhys , Cummins Phil R. , Hossen Jakir , Sambridge Malcolm , Hino Ryota , Inazu Daisuke 
Published: May 2016

AbstractThis paper studies the initial sea surface displacement and its uncertainty after an earthquake based on tsunami waveforms. The spatial distribution is inferred with a Bayesian approach that provides probabilities that are interpreted as uncertainties of the displaced sea surface. The parameterization is nonlinear and treats apparent rupture velocity as unknown but assumes rise time to be fixed at 30 s. Importantly, the spatial complexity of the source is constrained by observations using a transdimensional algorithm based on a wavelet decomposition of the displacement field. In this approach, the number of wavelet coefficients is an unknown random variable that is also estimated as part of the inversion. The resulting parameterization is parsimonious in that it can adapt to the spatially varying source complexity while being consistent with the information in the tsunami waveforms. In this way, the resolution of displacement varies across the source region with more parameters introduced for parts of the source that are resolved well by the data and/or have significant complexity. The noise level (standard deviation) at each gauge is initially treated as unknown to estimate data covariance matrices. These matrices are applied in subsequent inversion and include unknown scaling which eliminates the requirement to assume station weights and accounts for temporally correlated waveform noise. The method is applied to waveforms recorded during the 2011 Japan Tsunami and results show high resolution (low uncertainty) in most parts of the source region and a previously unreported level of source detail. In particular, the main peak of the source is elongated trench parallel and shows a well‐resolved bimodal finger‐like feature in the northern source region that closely follows the trench.
Enceladus's internal ocean and ice shell constrained from Cassini gravity, shape, and libration data
Authors: Čadek Ondřej , Tobie Gabriel , Van Hoolst Tim , Massé Marion , Choblet Gaël , Lefèvre Axel , Mitri Giuseppe , Baland Rose‐Marie , Běhounková Marie , Bourgeois Olivier , Trinh Anthony 
Published: May 2016

AbstractThe intense plume activity at the South Pole of Enceladus together with the recent detection of libration hints at an internal water ocean underneath the outer ice shell. However, the interpretation of gravity, shape, and libration data leads to contradicting results regarding the depth of ocean/ice interface and the total volume of the ocean. Here we develop an interior structure model consisting of a rocky core, an internal ocean, and an ice shell, which satisfies simultaneously the gravity, shape, and libration data. We show that the data can be reconciled by considering isostatic compensation including the effect of a few hundred meter thick elastic lithosphere. Our model predicts that the core radius is 180–185 km, the ocean density is at least 1030 kg/m3, and the ice shell is 18–22 km thick on average. The ice thicknesses are reduced at poles decreasing to less than 5 km in the south polar region.