bluuebunny/crossref_metadata_2025_split huggingface dataset:
To sandbox or not to sandbox? Diverging strategies of regulatory responses to FinTech
Authors: Raudla Ringa , Juuse Egert , Kuokštis Vytautas , Cepilovs Aleksandrs , Cipinys Vytenis , Ylönen Matti 
Published: September 2024

AbstractA regulatory sandbox is an emerging tool for addressing the challenges posed by the FinTech industry, but countries have embraced it to varying degrees. There is a need to systematically examine the question: Which factors explain the diverging trajectories in countries' decision to use (or not use) this instrument? This paper examines the adoption of regulatory sandboxes for FinTech in the Baltic states, where we can observe markedly divergent trajectories. Estonia has not exploited the possibilities of this instrument, while Lithuania and Latvia adopted a regulatory sandbox in 2018 and 2021, respectively. We analyze the political, legal, administrative, and economic factors affecting the adoption (or non‐adoption) of regulatory sandboxes for FinTech. We find that the decision to adopt a regulatory sandbox for FinTech is primarily influenced by the efforts of policy entrepreneurs, mechanisms of policy diffusion, and the policy actors' perceptions of legal constraints and available regulatory capacities.
Combating foodborne disease through household food handling behavior improvement: A comparison between education and price interventions
Authors: Zhang Meng , Wang H. Holly , Bai Junfei 
Published: September 2024

AbstractFoodborne disease cases are increasingly occurring in home kitchens because of improper food handling behavior. Human factors are considered major determinants of such behavior, although economic factors, which have attracted little attention, may also be important influencers. Taking the service time of kitchen towels as an example, we construct a theoretical model to analyze food handling behavior under an economic framework and empirically explore its economic determinants. Empirically, we use a randomized controlled trial (RCT) coupled with pre‐ and postsurveys in rural China. The RCT intervention includes information with tips for proper kitchen towel use and in‐kind subsidies of one, two, or three packs of kitchen towels, which is regarded as a price intervention. We find that information alone and information plus one pack of towels are not enough to stimulate behavior improvement, whereas information plus two or three packs is sufficient. This implies that the quantity of kitchen towels used increases only as the towel price drops below a certain threshold. As an early attempt, we indicate that food handling behavior is economically driven, suggesting that a well‐designed policy should combine educational campaigns and appropriate economic incentives to improve such behavior to reduce the risk of foodborne disease.
Multiple borders in one war: Constructing mental maps of Syrian refugees as threats
Authors: Skulte‐Ouaiss Jennifer , Diab Jasmin Lilian 
Published: September 2024

AbstractThis study delves into the intricate mechanisms by which states employ a complex network of competing and intersecting borders—both real and imagined—to delineate and perpetuate the image of Syrian refugees as security risks. Drawing upon insights from border studies, securitization theory, and framing analysis, we explore the nuanced processes of mental mapping and bordering within the context of the Syrian crisis. By scrutinizing the construction of these borders and mental maps, we highlight the deliberate state‐driven narrative that portrays Syrians as threats, emphasizing that such perceptions are not inherent but rather intentionally crafted. Our investigation sheds light on the state's agency in framing Syrians as threats, a narrative rarely challenged despite the multifaceted nature of the refugee crisis. Through an expanded discussion on historical, geopolitical, and socio‐cultural dimensions, we aim to provide a comprehensive understanding of the intricate dynamics underlying the portrayal of Syrian refugees as perennial security concerns.
Developing an instrument to measure Korean pre‐service teachers' understanding of language as an epistemic tool in mathematics education
Authors: Hwang Jihyun 
Published: September 2024

AbstractThis study adapted and validated an instrument to measure pre‐service teachers' understanding of language as an epistemic tool in mathematics education in South Korea. Initially validated for science education, the instrument was tailored for mathematics education and translated into Korean. The validation process included tests for content validity, substance validity through translation, and structural validity, affirming the instrument's efficacy in this new context. The rating scale model was employed to analyze raw response data and confirm a unidimensional model fit. To ensure the functional equivalence of translated items, rigorous domain reanalysis, translation, and back‐translation processes were implemented. A pilot study involving 215 Korean pre‐service teachers was conducted, yielding results that support the instrument's reliability and validity in measuring their understanding of language as an epistemic tool in mathematics. This adaptation provides a quantitative measure for this understanding and an example to revise the instrument for new contexts.
Is it useful to wash stored red blood cells in cardiopulmonary bypass priming fluid for neonatal cardiac surgery? A single‐centre retrospective study
Authors: Wang He , Jin Yu , Gao Peng , Liu Jia , Wang Wenting , Zhang Peiyao , Liu Jinping 
Published: September 2024

AbstractBackground and ObjectivesNeonatal cardiac surgery requires careful consideration of cardiopulmonary bypass (CPB) priming fluid composition due to small blood volume and immature physiology. This study investigated the impact of allogeneic stored red blood cells (RBCs) processed using an autotransfusion system in CPB priming fluid for neonates.Materials and MethodsWe compared perioperative parameters, inflammatory mediators, coagulation indicators, vasoactive‐inotropic score (VIS) and clinical outcomes between neonates receiving unwashed (n = 56) and washed (n = 45) RBCs in CPB priming fluid. Regression models were used to assess the independent association between RBC washing and patient outcomes.ResultsThe autotransfusion system improved stored RBC quality. The washed group showed higher peak haematocrit (p < 0.01) and haemoglobin levels (p = 0.04) during CPB, an increased oxygen delivery index during rewarming (p < 0.05) and lower postoperative lactate levels and VIS (p < 0.05). Inflammatory (IL‐6, IL‐8 and IL‐10) and coagulation parameters (D‐dimer, fibrinogen and fibrin degradation product) fluctuated compared with baseline but did not significantly differ between groups. The washed group had a lower incidence of hyperlactacidaemia and delayed sternal closure at CPB weaning.ConclusionsAdding washed allogeneic stored RBCs to neonatal CPB priming fluid reduced postoperative lactate elevation and VIS without early improvement in the inflammatory and coagulation systems.
Shaking Up Activity Counts: Assessing the Comparability of Accelerometers and Activity Count Computation
Authors: Coyle-Asbil Hannah J. , Murphy Bernadette , Vallis Lori Ann 
Published: September 2024

Accelerometers have been at the forefront of free-living activity capture for decades, and accordingly ActiGraph the largest distributor. Historically, limitations in data storage and battery power led to the use of summary metrics, which have been termed activity counts. Recently, ActiGraph publicly released their count-based algorithm, marking a notable development in the field. This study aimed to assess and compare activity counts generated through different processing techniques (ActiLife and open-source), filters that are available through ActiGraph count generation (normal- and low-frequency extension), and data from various ActiGraph models and GENEActiv devices. We evaluated ActiGraph GT3X+ (n = 8), ActiGraph wGT3X-BT (n = 10), ActiGraph GT9X (n = 8; primary and secondary sensors), OPAL (n = 6), and GENEActiv (n = 5), subjected to oscillations across their full dynamic range (0.005–8 G) using a multiaxis shaker table. Results indicated that the low-frequency extension produced significantly higher counts compared to the normal frequency across the devices and processing techniques. Notably, open-source counts (R and Python) were statistically equivalent to ActiLife-generated counts (p < .05) for the GT9X, wGT3X-BT, and the GT3X+. Overall, many of the counts generated by different ActiGraph models were statistically equivalent or had mean differences <5.03 counts. Conversely, the GENEActiv, OPAL, and GT9X secondary monitor exhibited significantly higher responses than the other ActiGraph models at higher frequencies with mean differences ranging from 55.50 to 104.91 counts. This study provides insights into accelerometer data processing methods and highlights the comparability of counts across different devices and techniques.
Genome sequences of 70 multidrug-resistant Gram-negative isolates in high-risk neonates in the Northeast of Mexico
Authors: Rodriguez-Orduña Lorena , Lara-Diaz Victor Javier , Alcorta-Garcia Mario René , Lopez-Villaseñor Claudia Nohemi , Licona-Cassani Cuauhtemoc 
Published: September 2024

ABSTRACT

Infections by multidrug-resistant pathogens are steadily increasing worldwide. A considerable proportion of neonatal intensive care admissions have a bacterial infection with multidrug-resistant bacteria during their hospital stay. In this work, we report draft genome sequences of 70 selected isolates from high-risk neonates in the Northeast of Mexico.
eIF6
deficiency regulates gut microbiota, decreases systemic inflammation, and alleviates atherosclerosis
Authors: Wang Zhenzhen , Yang Shuai , Tong Linglin , Li Xin , Mao Weiyi , Yuan Honghua , Chen Yang , Zhang Shenyang , Zhang He , Chen Renjin 
Published: September 2024

ABSTRACT

Altered composition of the gut microbiota affects immunity and metabolism. This study previously found that
eIF6
gene knockdown changes the composition of the intestinal flora in the
eIF6
gene knockdown mouse model.
Lactobacillus acidophilus
is significantly increased in the model. This study was designed to investigate the role of
L. acidophilus
in the pathogenesis of atherosclerosis. Transcriptomic data from 117 patients with coronary artery disease (CAD) and 79 healthy individuals were obtained.
ApoE
−/−
and
ApoE
−/−
/
eIF6
+/−
mice on normal chow diet or a high-fat diet were treated for 16 weeks;
eIF6
deficiency was evaluated atherosclerosis.
ApoE
−/−
mice on normal chow diet or a high-fat diet were treated with
L. acidophilus
by daily oral gavage for 16 weeks. Moreover, one group was treated with lipopolysaccharide at 12 weeks. The levels of
eIF6
,
RNASE3
, and
RSAD2
were notably higher in the patients with CAD than in the healthy individuals.
eIF6
deficiency altered the composition of gut microbiota.
eIF6
deficiency reduced the atherosclerotic lesion formation in
ApoE
−/−
/
eIF6
+/−
mice compared with the
ApoE
−/−
mice. The microbial sequencing and metabolomics analysis demonstrated some beneficial bacterial (
L. acidophilus
,
Ileibacterium
, and
Bifidobacterium
) and metabolic levels significantly had deference in
ApoE
−/−
/
eIF6
+/−
mice compared with the
ApoE
−/−
mice. Correlational studies indicated that
L. acidophilus
had close correlations with low-density lipoprotein cholesterol, lesion area, and necrotic area.
L. acidophilus
inhibited high-fat diet-induced inflammation and atherosclerotic lesion, increasing the expression of tight junction proteins (ZO-1 and claudin-1) and reducing the gut permeability. However, lipopolysaccharide reversed the protective effect of
L. acidophilus
against atherosclerosis.
eIF6
deficiency protected against atherosclerosis by regulating the composition of gut microbiota and metabolites.
L. acidophilus
attenuated atherosclerotic lesions by reducing inflammation and increasing gut permeability.

IMPORTANCE

eIF6
deficiency modulates the gut microbiota and multiple metabolites in atherosclerotic
ApoE

−/−

mice.
L. acidophilus
was reduced in the gut of atherosclerotic
ApoE

−/−

mice, but administration of
Lactobacillus acidophilus
reversed intestinal barrier dysfunction and vascular inflammation. Our findings suggest that targeting individual species is a beneficial therapeutic strategy to prevent inflammation and atherosclerosis.
Role of medical regulators in physician wellness: leading or lagging? A brief report on physician wellness practices
Authors: Reijmerink Iris , van der Laan Maarten J , Dongelmans Dave , Cnossen Fokie , Leistikow Ian 
Published: September 2024

BackgroundPhysician wellness remains a growing concern, not only affecting the physicians’ quality of life but also the quality of care delivered. One of the core tasks of medical regulatory authorities (MRAs) is to supervise the quality and safety of care. This brief report aimed to evaluate the practices of MRAs regarding physician wellness and their views on residents as a high-risk group for decreased physician wellness.MethodsA questionnaire was sent to MRAs worldwide, related to four topics: the identification of physician wellness as a risk factor for quality of care, data collection, interventions and the identification of residents as high risk for poor physician wellness. 26 responses were included.Results23 MRAs consider poor physician wellness a risk factor for quality of care, 10 collect data and 13 have instruments to improve physician wellness. Nine MRAs identify residents as a high-risk group for poor physician wellness. Seven MRAs feel no responsibility for physician wellness.ConclusionAlthough almost all MRAs see poor physician wellness as a risk factor, actively countering this risk does not yet appear to be common practice. Given their unique position within the healthcare regulatory framework, MRAs could help improve physician wellness.
El brazo político del campo científico: la Sociedad Brasileña para el Progreso de la Ciencia durante el gobierno de Jair Bolsonaro (2019-2022)
Authors: Scargiali Enzo Andrés 
Published: September 2024

The aim of the article is to explain the political intervention of the scientific field in the context of Jair Bolsonaro's government (2018-2022) in Brazil. The article is tributary to the analytical perspective of present-tense historical sociology, based on a temporal conception as a historical category and methodological perspective. In this sense, it analyzes a) the characterization of the right-wing forces in the Bolsonarist government, the main political and economic agents that support it, and the policies promoted for the area of science and technology; b) the social and political dimensions of the organization and political action of the Brazilian scientific field, taking into account its main organization, the Brazilian Society for the Progress of Science (SBPC) and its demands at this juncture in the face of the reduction in funding for the area and violations of academic freedom. About sources, the participation of SBPC referents and other relevant political and economic agents in the traditional media and in non-traditional spaces, as well as periodical publications in the field of science and technology. As well as periodical publications from the field and the state; official reports and statistical data.
Effect of two full-fat insect meals, yellow mealworm and black soldier fly larva, on growth performance of juvenile yellowtail
Authors: Ido A. , Takahashi T. , Miura C. , Hirayasu H. , Seyama T. , Miura T. 
Published: September 2024

Abstract
Given the expanding demand for fish meal (FM) worldwide, insect meal has become a promising alternative to FM for sustainable aquaculture. Yellowtail (Seriola quinqueradiata), the predominant farmed fish in Japan, is a carnivorous marine species that requires a substantial quantity of FM in its diet. Two feeding trials were conducted with the aim of assessing the applicability of two full-fat insect meals, yellow mealworm (Tenebrio molitor) meal (TM) and black soldier fly (Hermetia illucens) larvae meal (HI), as FM substitutes in for juvenile yellowtail. In the first trial, replacing 24.3% of FM with TM resulted in a final fish weight of 137.4 ± 40.1 g (mean ± SD as also indicated for subsequent values), comparable to the control group with a weight of 139.5 ± 44.0 g, while maintaining an equivalent level of n-3 fatty acid content across all diets used in the trial. The body weight of fish fed a diet containing HI, at 121.2 ± 31.0 g, was significantly lower than the control group, whereas the difference between fish fed a diet containing TM was not statistically significant. According to the growth analysis, dietary inclusion of TM was more suitable than that of HI, prompting a second trial to evaluate the maximum limit of FM substitution with TM without adjusting fatty acid profiles across diets. In the subsequent trial, fish growth exhibited a clear decrease trend with the inclusion rate of TM. These findings suggest that, while the substitution of FM with HI and TM has been shown to be feasible under equivalent fatty acid profiles in diets, the imbalanced fatty acid profile resulting from the inclusion of full-fat insects could be attributed to a deficiency in n-3 fatty acids, leading to the observed growth retardation in juvenile yellowtail.
“The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial”
Authors: Tohidi Mehdi , Allahyari Abolghasem , Ataei Azimi Sajjad , Alimi Hedieh , Elyasi Sepideh , Qoorchi Moheb Seraj Farid , Mehrad-Majd Hasan 
Published: September 2024

Background Anthracycline drugs play a fundamental role in breast cancer treatment; however, the cardiotoxicity side effects obscure the advantages of treatment. Curcumin has antioxidant and anti-inflammatory effects. Materials and Methods In this study, we investigated the effect of nanocurcumin supplementation on Doxorubicin induced Cardiotoxicity. In this randomized clinical trial, a week before starting the doxorubicin regimen for breast cancer patients, the control group received placebo and curcumin group received 80 mg daily dosage of nano curcumin capsules for six months. Echocardiography parameter changes before chemotherapy and after six months were evaluated. Results 46 patients were included. Left ventricle (LV) ejection fraction significantly decreased and LV end diastolic volume significantly increased in control group but no significant changes were observed in the curcumin group (LVEF: 2.62 ± 59.35 to 4.23 ± 56.85, p-value: 0.014 vs 59.55 ± 1.91 to 58.46 ± 3.41, p-value:0.135; LVEDV: 77.09 ± 15.33 to 80.65 ± 14.54, p-value:0.023 vs 72.41 ± 15.34 74.00 ± 14.25, p-value: 0.294). Additionally, LVEF, LV end systolic diameter (LVESD), and end diastolic diameter (LVEDD) insignificantly more decreased in control group versus curcumin group (LVEF: 4.13 ± 2.50- vs 3.36 ± 1.08-, p-value: 0.223; LVESD: 0.27 ± 0.06-vs 0.120.45 ±, p-value:0.110; LVEDD: −0.44 ± 0.33 vs 0.070.33 ±, p-value:0.269). Furthermore, symptomatic cardiomyopathy and ejection fraction ratio less than 53% were not observed. The LVEF reduction >15% was observed was also high in the control group, ( p-value = 0.020). Conclusion This study shows the possible effect of nanocurcumin capsules to reduce the cardiotoxicity of anthracycline chemotherapy medications.
Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction
Authors: Benkhoff Marcel , Alde Karin , Ehreiser Vincent , Dahlmanns Jana , Metzen Daniel , Haurand Jean M. , Duse Dragos Andrei , Jung Christian , Kelm Malte , Petzold Tobias , Polzin Amin 
Published: September 2024

Abstract
Platelets are crucial in thrombus formation during ST-elevation myocardial infarction (STEMI). In addition, they also play an important role in postischemic thromboinflammation, which is determined by the interplay between activated platelets and neutrophils. The latter form neutrophil extracellular traps, which are detectable in plasma as citrullinated histone H3–deoxyribonucleic acid-DNA complexes. Prediction of the risk of recurrent events is important in precision medicine. Therefore, we investigated whether circulating thromboinflammatory markers predict clinical outcome after STEMI. We performed a prospective, multicentric, observational, all-comer study of patients with STEMI (n = 361). Thromboinflammation, measured as H3Cit-DNA complexes, was assessed on day 1 after presentation with STEMI as well as 5 days and 6 months after STEMI by enzyme-linked immunosorbent assay. Twelve months of clinical follow-up was conducted. Multivariate analysis was performed investigating which variables were independently associated with major adverse cardiac events (MACEs). Patients were aged 64 ± 12 years; 80% were male; and 40% had diabetes mellitus. Thromboinflammation was enhanced during index hospitalization compared with 6-months follow-up (137.4 ± 100.0 μg/L vs 53.7 ± 54.7 μg/L; P &lt; .001). Additionally, patients within the highest tertile of thromboinflammation at day 1 after STEMI showed worse outcome during follow-up (hazard ratio, 2.57; 95% confidence interval, 1.72-3.85; P &lt; .001). Receiver operating characteristic analysis revealed a cutoff value of 219.3 μg/L. In multivariate logistic regression analysis, thromboinflammation was independently associated with outcome after STEMI. To sum it up, thromboinflammation is enhanced in STEMI. It identifies patients at high risk of MACE. Therefore, thromboinflammation might be a promising target and marker in precision medicine. The trial was registered at www.clinicaltrials.gov as #NCT03539133.