bluuebunny/crossref_metadata_2025_split huggingface dataset:
High throughput expression profiling and in situ screening of circular RNAs in tissues
Authors: Zaghlool Ammar , Ameur Adam , Wu Chenglin , Westholm Jakub Orzechowski , Niazi Adnan , Manivannan Manimozhi , Bramlett Kelli , Nilsson Mats , Feuk Lars 
Published: September 2017

AbstractCircular RNAs (circRNAs) were recently discovered as a class of widely expressed noncoding RNA and have been implicated in regulation of gene expression. However, the function of the majority of circRNAs remains unknown. Studies of circRNAs have been hampered by a lack of essential approaches for detection, quantification and visualization. We therefore developed a target-enrichment sequencing method suitable for high-throughput screening of circRNAs and their linear counterparts. We also applied padlock probes and in situ sequencing to visualize and determine circRNAs localization in human brain tissue at subcellular levels. We measured circRNA abundance across different human samples and tissues. Our results demonstrate the potential of this RNA class to act as a specific diagnostic marker in blood and serum, by detection of circRNAs from genes exclusively expressed in the brain. The powerful and scalable tools we present will enable studies of circRNA function and facilitate screening of circRNA as diagnostic biomarkers.
Discovery of Resistance Pathways to Fibroblast Growth Factor Receptor inhibition in Bladder Cancer
Authors: Pal Sumanta K , He Miaoling , Jones Jeremy O 
Published: September 2017

AbstractBackgroundAberrant fibroblast growth factor receptor (FGFR) signaling drives the growth of many bladder cancers. NVP-BGJ398 is a small molecule with potent inhibitory activity of FGFRs 1, 2, and 3, and has been shown to selectively inhibit the growth of bladder cancer cell lines that over-express FGFR3 or have oncogenic FGFR3 fusions. As with many agents targeting receptor tyrosine kinases, resistance is known to develop.ObjectiveWe sought to identify potential mechanisms of resistance to NVP-BGJ398 in cell culture models of bladder cancer.MethodsRT-112 bladder cancer cell lines were derived that were resistant to growth in 3uM NVP-BGJ398. RNA-sequencing was performed on resistant and parental cell lines to identify potential resistance mechanisms and molecular experiments were carried out to test these predictions.ResultsRNA-seq demonstrated decreased expression of FGFR3 and increased expression of FGFRs 1 and 2 in resistant cell lines. Over-expression of FGFR3 in NVP-BGJ398 resistant cells decreased their proliferation. Pathway analysis of RNA-seq data also implicated PIM kinase signaling, among other pathways, as a potential mediator of resistance. Treatment of BGJ398 resistant cells with the PIM kinase inhibitor SGI-1776 reduced the growth of the cells.ConclusionsOur results suggest that altered FGFR expression and PIM kinase activity could mediate resistance to NVP-BGJ398. These pathways should be investigated in samples from patients resistant to this drug.
Born into luxury: Paris Gallery of Dubai
Authors: Ahmad Syed Zamberi , Buchanan Frederick Robert , Ahmad Norita 
Published: August 2017

Subject area
Entrepreneurship, venture creation and business management.

Study level/applicability
The case is suitable for analysis in an undergraduates program specializing in entrepreneurship, business and management. The case could also be discussed in an executive development program on business ventures/business strategy/business management.

Case overview
Since its inception in 1981, Abdul Rahim Al Fahim, CEO Paris Gallery decided that Paris Gallery would foray into French perfumes. At that time, he would have never thought that such a move would ever make him more than a shopkeeper. Now in 2016, Mr Abdul Rahim Al-Fahim has much to be pleased about the success that his organization Paris Gallery (Luxury stores in Dubai) has been able to achieve. He has been twice named as the Arab World’s most powerful retail sector entrepreneur. Certainly, it was his good fortune to be based in the great city, and his business venture has paralleled the exponential success of Dubai. As the concept of grand malls developed and flourished in UAE, Paris Gallery stores emerged and also prospered. Currently, Paris Gallery has 80 stores in the finest locations of the Middle East. This encourages family business owners in UAE to have ambitions for success and growth of their enterprises. This is especially true in a developing region that has rarely hosted such a high-end homegrown success story as Paris Gallery. The study of strategic positioning of Paris Gallery with a workforce of 4,000 employees and representing more than 550 international brands today shall help us in weighing the options of how businesses should proceed strategically.

Expected learning outcomes
The following insights could be elucidated by the case: familiarizing students with the business challenges in the retail industry in emerging markets such as the United Arab Emirates, and exploring future strategy options from the business growth perspective.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 3: Entrepreneurship.
Emotional classification and visualization of movies based on their IMDb reviews
Authors: Topal Kamil , Ozsoyoglu Gultekin 
Published: August 2017

Purpose
The purpose of this study is to detect these reviews’ complex emotions, visualize and analyze them. Movie reviewers’ moviescores and reviews can be analyzed with respect to their emotion content, aggregated and projected onto a movie, resulting in an emotion map for a movie. It is then possible for a moviegoer to choose a movie, not only on the basis of movie scores and reviews, but also on the basis of aggregated emotional outcome of a movie as reflected by its emotion map displaying certain emotion map patterns desirable for the moviegoer.

Design/methodology/approach
The authors use the hourglass of emotion model to find the emotional scores of words of a review, then they use singular value decomposition to reduce the data dimension into singular scores. Once, they have the emotional scores of reviews, the authors cluster them by using k-means algorithm to find similar emotional levels of movies. Finally, the authors use heat maps to visualize four dimensions in a figure.

Findings
The authors are able to find the emotional levels of movie reviews, represent them in single scores and visualize them. The authors look the similarities and dissimilarities of movies based on their genre, ranking and emotional statuses. They also find the closest emotion levels of movies to a given movie.

Originality/value
The authors detect complex emotions from the text and simply visualize them.
Experimental and numerical investigations of the composite behaviour in concrete-filled tubular columns with massive steel core at high temperatures
Authors: Schaumann Peter , Kleibömer Inka 
Published: August 2017

Purpose
This paper deals with experimental and numerical investigations of the composite behaviour within concrete-filled tubular columns with embedded massive steel core (CFTES columns). As the inner profile provides the main load-bearing capacity, the load introduction and transfer is of particular interest for the structural detailing of CFTES columns. Currently, no specific design regulations are available – neither for room temperature nor fire design. The presented investigations provide a basis for design recommendations and numerical approaches on reliable shear stresses.

Design/methodology/approach
Three series of push-out tests at room temperature and high temperatures are analysed in terms of ultimate shear strength, bond strength and shear strength-displacement-curve shape. The test parameters involve the steel core diameter and concrete cover, applying normal strength steel and concrete. Furthermore, a three-dimensional finite element model of the push-out tests is set up in Abaqus. The model implies temperature-dependent contact properties derived from the experimental tests using the cohesive behaviour method.

Findings
The test data reveal a distinctive reduction in both ultimate shear and bond strength for high temperatures. For high temperatures, the thermal expansion coefficients dominate the composite behaviour. Using the 3D numerical model and applying a temperature-dependent joint stiffness, maximum shear stress criterion and damage evolution, the observed composite behaviour can be described in a realistic manner.

Originality/value
The presented experimental investigations are unique, both concerning the investigated column type and performing push-out tests at high temperatures. For the first time, a temperature-dependent reduction of capable shear stresses is identified, which is crucial for the design of structural components.
Sense of community, organizational commitment and quality of services
Authors: Lampinen Mai-Stiina , Suutala ElinaAnnikki , Konu Anne Irmeli 
Published: September 2017

PurposeThe purpose of this paper is to examine how factors associated with a sense of community in the workplace are connected with organizational commitment and the quality of services among frontline managers and middle managers in social and health care services in Finland.Design/methodology/approachA questionnaire designed specifically for this research was sent to 241 lower-level and middle-level managers in social and health care services in central Finland. A total of 136 managers completed the questionnaire (response rate 56 per cent). The results were analyzed using descriptive statistics, exploratory factor analysis, Spearman’s rank-order correlation coefficient and multiple linear regression analyses.FindingsThe study showed that feeling a sense of belonging, mutual trust and appreciation, and open interaction among colleagues were connected to organizational commitment for frontline managers and middle managers in social and health care services in Finland. Correspondingly, an open flow of information in the organization, job meaningfulness and appreciation received from managers’ superiors were connected to the quality of services.Originality/valueThis study provides information on the factors that influence social and health care managers’ organizational commitment and on items connected to their experience of the quality of services.
Value-based healthcare as a trigger for improvement initiatives
Authors: Nilsson Kerstin , Bååthe Fredrik , Erichsen Andersson Annette , Sandoff Mette 
Published: September 2017

Purpose
This study explores four pilot teams’ experiences of improvements resulting from the implementation of value-based healthcare (VBHC) at a Swedish University Hospital. The aim of this study is to gain a deeper understanding of VBHC when used as a management strategy to improve patients’ health outcomes.

Design/methodology/approach
An exploratory design was used and qualitative interviews were undertaken with 20 team members three times each, during a period of two years. The content of the interviews was qualitatively analysed.

Findings
VBHC worked as a trigger for initiating improvements related to processes, measurements and patients’ health outcomes. An example of improvements related to patients’ health outcomes was solving the problem of patients’ nausea. Improvement related to processes was developing care planning and increasing the number of contact nurses. Improvement related to measurements was increasing coverage ratio in the National Quality Registers used, and the development of a new coding system for measurements. VBHC contributed a structure for measurement and for identification of the need for improvements, but this structure on its own was not enough. To implement and sustain improvements, it is important to establish awareness of the need for improvements and to motivate changes not just among managers and clinical leaders directly involved in VBHC projects but also engage all other staff providing care.

Originality/value
This study shows that although the VBHC management strategy may serve as an initiator for improvements, it is not enough for the sustainable implementation of improvement initiatives. Regardless of strategy, managers and clinical leaders need to develop increased competence in change management.
Collaborating for metadata creation on digital projects: using Google Forms and Sheets
Authors: Knight R. Cecilia , Rodrigues Elizabeth , Ciota Rebecca 
Published: August 2017

Purpose
Working with faculty and staff to create digital projects requires a complex group of skills and activities. Potential collaborators often jump to the end vision without fully grasping the need for proper description and metadata.

Design/methodology/approach
On-the-job experiences. Contextual inquiry.

Findings
Using Google Forms and Sheets is perceived of as neutral and less frightening than working in a platform that will be the home of the project or using other proprietary productivity software.

Social implications
Digital scholars gradually come to understand the stakes of early decisions in metadata creation (such as file naming conventions and controlled vocabulary) and how that affects database structures, record display, keyword searching and long-term curation.

Originality/value
The authors did not find any other publications addressing using Google Apps for creating metadata.
The relationship of individual spirituality and organizational spirituality with meaning and community at work
Authors: Pawar Badrinarayan Shankar 
Published: August 2017

PurposeThe purpose of this paper is to carry out an empirical examination to assess the nature of effects an employee’s individual spirituality and organizational spirituality have on the employee’s experience of meaning in work and community at work facets of workplace spirituality.Design/methodology/approachThis paper specifies and examines, using a cross-sectional survey research design, the empirical support for two alternative models – a direct effects model and a moderating effect model – of the likely influences of an employee’s individual spirituality and organizational spirituality on the meaning and community facets of workplace spirituality.FindingsThe findings indicate considerable support for the direct effects model but no support for the moderating effect model. Within the direct effects model, organizational spirituality had much stronger association than employees’ individual spirituality with the workplace spirituality facets of meaning and community.Research limitations/implicationsThis study may encourage future research to examine other antecedents of workplace spirituality, and the moderators and mediators of the relationship between organizational spirituality and workplace spirituality.Practical implicationsIt suggests to the practitioners that for enhancing employee experiences of workplace spirituality, organizational spirituality implementation is a more effective way than developing employees’ individual spirituality.Social implicationsThe study indicates that employees’ spiritual needs of meaning and community at work can be better fulfilled through organizational spirituality implementation than through individual spirituality development.Originality/valueThis is an original empirical examination and its value partly comes from its research implications and practice implications.
The consequences of outness: gay men’s workplace experiences
Authors: Wicks David 
Published: August 2017

Purpose
The purpose of this paper is to explore the positive and negative workplace experiences of gay men that they perceive to be a consequence of their sexual identity.

Design/methodology/approach
This paper uses in-depth interviews of a diverse group of university educated white collar men employed full-time in the public and private sector. Its findings are based on a thematic content analysis of these interviews.

Findings
Despite experiencing some negative consequences of being out at work, their positive and neutral experiences show encouraging signs of increasingly tolerant workplaces. Some of the challenges encountered that respondents believe to be a consequence of their sexual identity are, however, not dissimilar to those faced by workers with non-traditional families.

Research limitations/implications
As with any small sample exploratory qualitative research, this paper’s findings cannot necessarily be generalized to larger populations. The uniqueness of the sample (ethnically/culturally homogenous, university educated, public/private sector employees, residents of medium-sized Canadian city) allow for display of certain experiences not representative of the population at large.

Originality/value
This paper contributes to the relatively small but growing body of research on the experience of sexual minorities in the workplace. Its findings challenging the notion that sexual minorities are uniquely advantaged in the workplace, and that research on sexual minorities in the workplace is misguided in focusing on the problematic aspects of sexual identity/orientation.
The Building a New Life in Australia (BNLA) Dataset: A Longitudinal Study of Humanitarian Migrants in Australia
Authors: Rioseco Pilar , De Maio John , Hoang Cuc 
Published: September 2017

AbstractThis article presents an introduction to the Building a New Life in Australia (BNLA) dataset, a large‐scale longitudinal study of humanitarian migrants in Australia. We outline the main characteristics of the study and provide an overview of the measures available and potential uses. The first three waves of the BNLA data are currently available to approved users, covering the first three years of the settlement journey of a recent cohort of humanitarian migrants in Australia.
Efficacy and safety of ultrasound‐guided high intensity focused ultrasound ablation of symptomatic uterine fibroids in Black women: a preliminary study
Authors: Zhang C , Jacobson H , Ngobese ZE , Setzen R 
Published: September 2017

ObjectiveTo evaluate the therapeutic effect and safety of ultrasound‐guided high‐intensity focused ultrasound (USgHIFU) treatment on symptomatic uterine fibroids in Black women.DesignA feasibility study.SettingGynaecological department in a teaching hospital in South Africa.PopulationPremenopausal women with uterus fibroids.MethodsTwenty‐six patients with 53 fibroids who underwent USgHIFU treatment were enrolled. The USgHIFU treatment information was recorded, including treatment time, sonication time and total energy. Adverse events were also observed and recorded during and after treatment.Main outcome measuresSafety and efficacy of USgHIFU for the treatment of uterine fibroids in Black women.ResultsThe median volume of fibroids was 52.7 (interquartile range, 18.6–177.4) cm3. According to USgHIFU treatment plan, total energy of 298.6 ± 169.3 kJ (range, 76.0–889.2) within treatment time of 90.3 ± 43.3 minutes (range, 14.0–208.0), in which sonication time of 774.0 ± 432.9 seconds (range, 190.0–2224.0) was used to ablate fibroids. The average ablation rate was 80.6 ± 9.7% (range, 46.5–94.5%). During the procedure, 69.2% of the patients reported lower abdominal pain, 57.7% sciatic/buttock pain, 38.5% burning skin, and 34.6% transient leg pain. No severe complications were observed.ConclusionsUSgHIFU is feasible and safe to use to treat symptomatic uterine fibroids in Black women.Tweetable abstractMultiple uterine fibroids are more frequently detected in Black women. USgHIFU is feasible and safe for the treatment of uterine fibroids in Black women.
Short‐ and long‐term efficacy of focused ultrasound therapy for non‐neoplastic epithelial disorders of the vulva
Authors: Wu C , Zou M , Xiong Y , Wang L , Chen H , Fan Y , Li C 
Published: September 2017

ObjectiveTo investigate the short‐ and long‐term efficacy and influential factors of focused ultrasound for the treatment of non‐neoplastic epithelial disorders of the vulva (NNEDV).DesignA retrospective observational study.SettingA gynaecologic department in a single centre in China.PopulationPatients with NNEDV were included in this study: 85 patients were diagnosed with lichen simplex chronicus (LSC), 44 patients with vulva lichen sclerosus (VLS), and seven patients with lichen planus (LP).MethodsA total of 136 eligible patients with NNEDV were treated with focused ultrasound. After the treatment, based on changes in the degree of symptom severity and local skin signs (lesion size, skin colour and elasticity) before and after treatment, the treatment effectiveness for each patient was assessed. We further analysed the relations among pathologic type, age, course and curative rate. Statistical analysis was performed using the Chi‐square (McNemar) test.Main outcome measuresImprovement in the symptoms and physical signs and the predictive factors.ResultsSymptom relief was observed in all patients. The appearance and colour of the vulva returned to normal after the ultrasound treatment. Complete remission (CR) occurred in 68 of 136 (50%) patients (41 patients with LSC and 12 patients with VLS). The response rate was 93.38% (127/136). Seven patients who had a poor response to the first session of treatment were treated again with ultrasound therapy and a good response was observed. No severe complications were observed. There was no significant difference in treatment results among the different pathological types (P > 0.05). However, the course of the disease and the age of the patients were related to the treatment results (P < 0.05).ConclusionsNNEDV can be treated with focused ultrasound effectively and safely. The course of the disease and the age of the patients may be predictive factors.Tweetable abstractPatients with non‐neoplastic epithelial disorders of the vulva can be safely and effectively treated with focused ultrasound. No significant difference in treatment results was observed between the different types of non‐neoplastic epithelial disorders of the vulva.
Simple politics for the people? Complexity in campaign messages and political knowledge
Authors: BISCHOF DANIEL , SENNINGER ROMAN 
Published: August 2017

AbstractWhich parties use simple language in their campaign messages, and do simple campaign messages resonate with voters’ information about parties? This study introduces a novel link between the language applied during election campaigns and citizens’ ability to position parties in the ideological space. To this end, how complexity of campaign messages varies across parties as well as how it affects voters’ knowledge about party positions is investigated. Theoretically, it is suggested that populist parties are more likely to simplify their campaign messages to demarcate themselves from mainstream competitors. In turn, voters should perceive and process simpler campaign messages better and, therefore, have more knowledge about the position of parties that communicate simpler campaign messages. The article presents and validates a measure of complexity and uses it to assess the language of manifestos in Austria and Germany in the period 1945–2013. It shows that political parties, in general, use barely comprehensible language to communicate their policy positions. However, differences between parties exist and support is found for the conjecture about populist parties as they employ significantly less complex language in their manifestos. Second, evidence is found that individuals are better able to place parties in the ideological space if parties use less complex campaign messages. The findings lead to greater understanding of mass‐elite linkages during election campaigns and have important consequences for the future analysis of manifesto data.