bluuebunny/crossref_metadata_2025_split huggingface dataset:
Framing the “Oldest Alliance”: Treaty-Making in Fourteenth-Century England and Portugal
Authors: Faria Tiago Viúla de 
Published: September 2024

Abstract
Few treaties before the Peace of Westphalia are likely to have affected popular culture as much as the so-called Treaty of Windsor, celebrated in 1386–87 between the rulers of England and Portugal, which has commonly been hailed as the oldest diplomatic alliance in place worldwide. A lesser-known fact is that the Treaty of Windsor was the last of four treaties signed in a relatively short span of 33 years, beginning in 1353. This essay examines each of those compositions’ context, making, content, and constitutional significance once they came into being. Considering the ever-changing political developments of the Hundred Years’ War and parallel Anglo-Portuguese commercial interests, which ran deeper, ultimately this essay questions the significance of late medieval treaties and the Anglo-Portuguese alliance as a political creation.
Analyzing Alignment Error in Tibial Tuberosity–Trochlear Groove Distance in Clinical Scans Using 2D and 3D Methods
Authors: Sieberer Johannes M. , Park Nancy , Rancu Albert L. , Desroches Shelby T. , McDonald Curtis , Manafzadeh Armita R. , Tommasini Steven M. , Wiznia Daniel H. , Fulkerson John P. 
Published: September 2024

Background: Tibial tuberosity–trochlear groove distance (TT-TG) is often used as a primary metric for surgical decision-making in the treatment of patellofemoral instability (PFI), particularly when considering tibial tubercle transfer. Although TT-TG has high interrater reliability, it is prone to measurement differences caused by the alignment of the patient's leg in a scanner gantry, potentially influencing surgical decision-making. Quantification of this error within the clinical literature remains limited. Purpose: To quantify and specify the error in TT-TG caused by leg-scanner alignment by using detailed topographical landmarks and 3-dimensional (3D) analysis of computed tomography scans of patients with PFI. Study Design: Controlled laboratory study. Methods: Three-dimensional models of knees with PFI were created from computed tomography scans and used to identify TT-TG landmarks. TT-TG was measured using the established 2-dimensional (2D) and 3D methods. A model to estimate the differences between these 2 methods was created, and the orientation of the patients’ legs in relation to scanner longitudinal axis was measured to validate this model via linear regression. Interrater reliability was calculated via intraclass correlation coefficients (ICC). Results: A total of 44 knees of patients with PFI were analyzed. Differences between the 2D and 3D methods ranged from -4.0 to 14.7 mm (mean ± SD, 2.7 ± 4.1 mm) with a root mean square difference of 4.8 mm. The TT-TG distance of the 2D method (19.8 ± 7.2 mm) was significantly ( P = .045) longer than that of the 3D method (17.1 ± 4.9 mm). The variance of the 2D method was significantly larger than that of the 3D method. In total, 13 (29.5%) of the knees had a difference of >5 mm between 2D and 3D TT-TG. The estimation model had an adjusted r2 value of 1.00 and a resulting root mean square difference of 0.21 mm. 3D TT-TGs interrater reliability was good to excellent (ICC, 0.94 [95 CI%, 0.81-0.98]). Conclusion: 3D TT-TG can be used to correct scanner-leg alignment errors, some of which are substantial when using only 2D TT-TG measurements. Clinical Relevance: The findings in this study suggest a need for caution and awareness of the potential effects of differences in alignment of the axes of the leg and scanner when using purely 2D TT-TG as a basis for surgical planning.
The Association Between Screening for Colorectal Cancer and Mental and Physical Health
Authors: Gong Yiting , Flander Louisa B. , Macrae Finlay , Wilson Carlene , Jenkins Mark A. 
Published: September 2024

Background Colorectal cancer screening reduces colorectal cancer morbidity and mortality. Identifying the factors associated with screening participation is needed to overcome barriers to screening. While several of those factors have been identified, the impact of mental and physical health on screening behaviour is not well understood. Methods This retrospective cohort study compared the self-reported mental and physical health of those who did screen for colorectal cancer and those who did not. Participants of the Australasian Colorectal Cancer Family Registry Cohort that were aged 45-75 years and had never been diagnosed with colorectal cancer were asked to complete a questionnaire detailing their colorectal cancer screening participation in the preceding 5 years, and a validated questionnaire of mental and physical health. Multivariable logistic regression was used to adjust for measured potential confounders. Results Of the 1130 eligible participants, 781 had a family history of colorectal cancer (69.5%), and 819 reported colorectal cancer screening in the past 5 years (72%). After adjusting for potential confounders, there was no evidence that overall mental or physical health was associated with colorectal cancer screening. However, those reporting higher levels of general health were more likely to participate in colorectal cancer screening (OR = 1.02 (100 point scale), 95% CI 1.004, 1.037, P = .014). Conclusion We found limited evidence that mental and physical health were associated with colorectal cancer screening. The high proportion of participants with a family history of colorectal cancer limits the generaliseability of the findings to the general population, although we observed no differences in findings by strength of family history.
Comparing E-Cigarettes and Traditional Cigarettes in Relation to Myocardial Infarction, Arrhythmias, and Sudden Cardiac Death: A Systematic Review and Meta-Analysis
Authors: Yacoub Mohammed I. , Aslanoğlu Aziz , Khraim Fadi , Alsharawneh Anas , Abdelkader Raghad , Almagharbeh Wesam T. , Alhejaili Asim Abdullah , Alshahrani Bassam Dhafer , Sobeh Dena Eltabey , Eltayeb Mudathir M. , Elshatarat Rami A. , Saleh Zyad T. 
Published: September 2024

Background The use of electronic cigarettes (e-cigarettes) as a perceived safer alternative to traditional cigarettes has grown rapidly. However, the cardiovascular risks associated with e-cigarettes compared to regular cigarettes remain unclear. Objective To systematically review and compare the cardiovascular outcomes of e-cigarette use versus traditional cigarette use, focusing on the risks of myocardial infarction, arrhythmias, and sudden death. Methods A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Peer-reviewed studies published in English were included if they reported cardiovascular outcomes related to e-cigarette or traditional cigarette use. A total of 20 studies were included, covering observational and interventional studies focusing on heart rate variability, myocardial infarction, arrhythmias, and sudden cardiac events. The quality of the evidence was assessed using the GRADE criteria, and data were extracted and analyzed based on the PICOS (Population, Interventions, Comparisons, Outcomes, and Study designs) framework. Results The systematic review found that both e-cigarettes and traditional cigarettes pose significant cardiovascular risks, with traditional cigarettes linked to a higher incidence of myocardial infarction, arrhythmias, and sudden cardiac death. E-cigarette users also face increased risks of arrhythmias and myocardial infarction compared to non-smokers, primarily due to the constituents of aerosolized e-liquid, including nicotine and flavorings, which contribute to adverse cardiac effects. Regular e-cigarette use, particularly in combination with traditional cigarette use, was associated with a heightened risk of myocardial infarction. Studies also reported heart function abnormalities, such as systolic and diastolic dysfunction, and reduced ejection fractions. Additionally, changes in heart rate variability, heart rate, and blood pressure were observed, indicating both acute and chronic effects of e-cigarettes on cardiovascular autonomic regulation. Conclusions While e-cigarettes may present a lower cardiovascular risk compared to traditional cigarettes, they are not without harm. Both products are linked to increased risks of myocardial infarction and arrhythmias, though traditional cigarettes pose a higher overall threat. Given the limitations in the current evidence base, particularly concerning the long-term effects of e-cigarette use, further research is needed to clarify these cardiovascular risks and inform public health guidelines.
Environmental Dimension of Value Chain Linkages: Empirical Assessment of India’s Manufacturing Sector
Authors: Bhayana Sakshi , Nag Biswajit 
Published: September 2024

The emergence of global value chains (GVCs) has presented emerging nations like India with possibilities to combine into the worldwide economic system, which has had a major effect on the economy and the environment. With India’s manufacturing sector accounting for 15% of India’s gross value added, it is one of the main engines of the country’s economic expansion. Additionally, it is vulnerable to changes in technology and ranks second in terms of carbon dioxide (CO2) emissions, after the production of electricity. This study attempts to draw interrelations between CO2 emissions embodied in trade and GVC participation for this sector. Using the autoregressive distributive lag approach for the time period 1995–2018, this study exhibits significant cointegration between value chain participation and embodied emissions in gross exports for the short run and long run. However, while the impact of economic growth is positive for foreign emissions embodied through imported intermediates and negative for the emissions embodied in India’s exports of domestic goods, there exist important policy implications in this regard. Also, it is vital for an emerging nation like India to accord primacy to other indicators like the Environmental Stringency Index and spending on research and development so as to reduce its carbon emissions and improve its ecology. Novelty in this study arises from the fact that it utilises inter-country input–output statistics, OECD on fuel combustion to the resident industry and household, where carbon emissions have been decomposed into the foreign and domestic emissions embodied in gross exports for India’s manufacturing sector. JEL Classification: F110, F664, B223
Developing and evaluating Compassionate Workplace Programs to promote health and wellbeing around serious illness, dying and loss in the workplace (EU-CoWork): a transdisciplinary, cross-national research project
Authors: Vanderstichelen Steven , De Moortel Deborah , Nielsen Karina , Wegleitner Klaus , Eneslätt Malin , Sardiello Tiziana , Martos Daniela , Webster Jennifer , Nikandrou Irene , Delvaux Ellen , Tishelman Carol , Cohen Joachim 
Published: September 2024

Background: Most employees will experience serious illness, caregiving, dying and loss (End-of-Life (EoL) experiences) at multiple points throughout their working lives. These experiences impact affected employees but also their colleagues in terms of health and wellbeing, and the workplace as a whole in terms of workplace safety, productivity and labour relations. The impact of EoL experiences on employees means that workplaces are called to play a more active role in providing support for EoL experiences. Aim: To describe how the EU-CoWork (2024–2028) project addresses its main aims to (1) create Compassionate Workplace cultures, practices and policies and improve health and wellbeing for employees dealing with EoL experiences in different national work contexts in Europe; (2) describe and evaluate the process of co-creation and implementation of Compassionate Workplace Programs (CWPs) and how these influence the programs’ outcomes. Design: EU-CoWork employs a facilitated and co-creative Developmental Evaluation approach to the development of 12 tailored CWPs across four European countries (Belgium, Austria, Sweden and Greece). Methods: To evaluate the outcomes and processes leading to these outcomes, a mixed-methods Realist Evaluation methodology is applied, formulating and testing Context-Mechanism-Outcomes configurations and combining longitudinal quantitative and qualitative data collections. Results: EU-CoWork will generate evidence to support an expanded model of occupational health and safety risk factors sensitive to the specific challenges related to employees’ EoL experiences. In doing so, several challenges will have to be navigated: involving employees with EoL experiences while avoiding overburdening them, avoiding tokenistic engagement, managing power differentials, balancing the need for scientific rigour with the flexibility required in co-creation, reconciling different epistemologies and disciplinary traditions and organisational resistance to change. Conclusion: There are potential long-lasting broader societal impacts through the stimulation of open discourse on EoL topics, the reconciliation of work and care, and changes in gendered work and care patterns.
Magnetite nanoparticles are metastable biogeobatteries in consecutive redox cycles driven by microbial Fe oxidation and reduction
Authors: Bayer T. , Jakus N. , Kappler A. , Byrne J. M. 
Published: September 2024

Abstract
Iron (Fe) minerals play a crucial role in biogeochemical cycles due to their ubiquity in nature, high adsorption capacity and redox activity towards many other elements. Mixed-valent Fe minerals are unique since they contain Fe(II) and Fe(III). For example, magnetite (Fe(II)Fe(III)2O4) nanoparticles (MNPs) can affect the availability and mobility of nutrients and contaminants. This is due to the high surface area to volume ratio and the presence of Fe(II) and Fe(III), allowing redox transformation of (in‑)organic contaminants. Recent studies have shown that magnetite can serve as an electron source and sink for Fe(II)-oxidizing and Fe(III)-reducing microorganisms, storing and releasing electrons; thus, it functions as a biogeobattery. However, the ability of MNPs to act as biogeobatteries over consecutive redox cycles and the consequences for mineral integrity and identity remain unknown. Here, we show MNPs working as biogeobatteries in two consecutive redox cycles over 41 days. MNPs were first oxidized by the autotrophic nitrate-reducing Fe(II)-oxidizing culture KS and subsequently reduced by the Fe(III)-reducing Geobacter sulfurreducens. In addition to reduced magnetite, we identified the Fe(II) mineral vivianite after reductions, suggesting partial reductive dissolution of MNPs and re-crystallization of Fe2+ with phosphate from the growth medium. Measurements of the Fe(II)/Fe(III) ratio revealed microbial oxidation and reduction for both the first redox cycle (oxidation: 0.29±0.014, reduction: 0.75±0.023) and the second redox cycle (oxidation: 0.30±0.015, reduction: 1.64±0.10). Relative changes in magnetic susceptibility (∆κ in %) revealed greater changes for the second oxidation (–8.7±1.99%) than the first (–3.9±0.19%) but more minor changes for the second reduction (+14.29±0.39%) compared to the first (+25.42±1.31%). Our results suggest that MNPs served as biogeobatteries but became less stable over time, which has significant consequences for associated contaminants, nutrients and bioavailability for Fe-metabolizing microorganisms.
Remote fitness assessment in younger and middle-aged to older adults: a comparison between laboratory- and videoconference-based assessment of selected measures of physical and cognitive fitness
Authors: Theobald Paula , Herold Fabian , Gronwald Thomas , Müller Notger G. 
Published: September 2024

Abstract
Background
Digital technologies can play an important role in improving the limited accessibility of healthcare services in rural regions (e.g., via remote assessment). However, whether remote fitness assessments (RFA) of selected physical and cognitive fitness parameters are feasible both in younger and older persons and whether they can reproduce laboratory tests needs yet to be established. Thus, this study aimed to address this knowledge gap by investigating the feasibility, and reproducibility of RFA in younger and middle-aged to older adults (MOA).

Methods
A total of 31 younger adults and 32 MOAs participated in this study. At an interval of seven days, laboratory-based and remote assessments (via videoconferencing software) were conducted which included the quantification of the following parameters: (i) measurement of heart rate variability [HRV]; followed by (ii) cognitive testing to examine the level of attention, executive functions (oral Trail Making Test [A and B]), working memory, verbal short-term memory (digit span memory test and word list test (immediate recall)) and episodic memory (word list test (delayed recall)); followed by (iii) physical fitness assessments including performance tests of balance (balance test), functional strength ability of the lower limbs (5-time-sit-to-stand-test) and endurance capacity (3-min step test). Parameters of absolute and relative reliability were determined to assess the reproducibility of the laboratory-based and remote assessments.

Results
The selected physical and cognitive fitness parameters showed moderate to excellent relative reliability (intraclass correlation coefficient [ICC] = 0.52—0.95). The parameters of absolute reliability (Bland–Altman plot and standard error of measurement [SEM]) provide evidence for good reproducibility of HRV parameters and measures of physical fitness, whereas measures of cognitive fitness showed moderate to good reproducibility. On a descriptive level, the absolute and relative reliability of the selected measures of physical and cognitive fitness did not vary as a function of participants’ age.

Conclusion
Our results suggest that RFA of selected measures of physical and cognitive fitness is feasible and reproduces corresponding laboratory results to a moderate to excellent level in both younger adults and MOA. Data showed that the reproducibility of laboratory-based and remote assessments is not influenced by the age of the participants. These findings support the use of digital technologies to improve the accessibility of healthcare services (e.g., in remote areas). However, as the reproducibility varies considerably across the different parameters, further studies are needed to evaluate the effects of an optimised standardisation of the remote assessments and confounding factors.
Study of adiponectin gene (rs1501299) polymorphism and serum adiponectin level in patients with primary knee osteoarthritis
Authors: Elnemr Rehab , EL Hamid Mowaffak Moustafa Abd , Taleb Raghda Saad Zaghloul , Khalil Naylan Fayez Wahba , El-Sherif Sherine Mahmoud 
Published: September 2024

Abstract
Background
We aimed to study, for the first time in the Egyptian population, the relationship between the serum adiponectin level in knee osteoarthritis (KOA) patients and its correlation with clinical, radiological, and ultrasonographic characteristics. Additionally, investigate the relationship between the adiponectin (ADIPOQ) gene rs1501299 (+ 276G/T) polymorphism and KOA susceptibility and severity.

Methods
This case-control study enrolled 40 patients with primary KOA and 40 matched controls. All patients underwent physical examination of the knee, pain assessment using the visual analogue scale (VAS), and functional evaluation by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Severity of KOA was assessed by Kellgren Lawrence (KL) grading scale and ultrasonography grading systems. Serum adiponectin levels and adiponectin (ADIPOQ) gene single nucleotide polymorphism (SNP) (rs1501299) genotyping were done for all patients and controls.

Results
The study included 40 patients with primary symptomatic KOA and 40 controls with comparable age, sex, and body mass index. The genotype of the rs1501299 (+ 276G/T) polymorphism of the ADIPOQ gene was determined using TaqMan allelic discrimination. An enzyme-linked immunosorbent test was used to measure the level of serum adiponectin. The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score was used to assess functional capability, while the visual analogue scale was utilised to assess knee pain. Using the Kellgren-Lawrence (KL) grading method and global femoral cartilage (GFC) ultrasound grading, the severity of KOA was assessed. No significant differences between patients and controls as regards the genotype distributions and allele frequencies (p = 0.400, p = 0.507, respectively) of ADIPOQ gene rs1501299 (+ 276G/T) polymorphism. Furthermore, serum adiponectin level was significantly higher in the patients compared to healthy subjects (p < 0.001). Additionally, adiponectin level had a significant negative correlation with disease severity as evaluated by KL and GFC grading (r=-0.351, p = 0.027 and r=-0.397, p = 0.011, respectively).

Conclusions
The ADIPOQ gene rs1501299 (+ 276G/T) polymorphism was not associated with KOA severity or vulnerability. The level of adiponectin considerably reduced as the severity of KOA rose, indicating that adiponectin may have a preventive effect in KOA.
Understanding violence in the context of psychosis: contribution of phenomenology and its limitations
Authors: Ryland Howard 
Published: September 2024

SUMMARYNavigating the complex relationship between violence and psychosis can frequently be challenging. Psychiatrists may find assessing and managing the risk of violence in this context daunting. In their article on the topic, Anderson et al helpfully summarise the role that psychopathology can play in this process. However, although careful elucidation of an individual's experiences may assist in the nuanced formulation of their risk and could offer a specific focus for interventions, the approach has potential shortcomings in certain settings. For some phenomena the link with violence is unclear and it may be constellations of symptoms that are important. Causal pathways are not always linear and there may be important mediators linking psychopathological features to behavioural outcomes. In the resource-limited settings in which many contemporary health services operate, a detailed assessment of psychopathology may be hampered by time or other constraints. Alternative, more scalable solutions may therefore be needed in particular scenarios.