bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel ATTR L32V mutation causes familial amyloid polyneuropathy in a Bolivian family
Authors: Martínez‐Ulloa Pedro L. , Vallejo Manuela , Corral Iñigo , García‐Barragán Nuria , Alcazar Alberto , Martínez‐Alonso Emma , Martínez‐Poles Javier , Pian Hector , Jiménez‐Escrig Adriano 
Published: June 2017

AbstractWe report a new transthyretin (ATTR) gene c.272C>G mutation and variant protein, p.Leu32Val, in a kindred of Bolivian origin with a rapid progressive peripheral neuropathy and cardiomyopathy. Three individuals from a kindred with peripheral nerve and cardiac amyloidosis were examined. Analysis of the TTR gene was performed by Sanger direct sequencing. Neuropathologic examination was obtained on the index patient with mass spectrometry study of the ATTR deposition. Direct DNA sequence analysis of exons 2, 3, and 4 of the TTR gene demonstrated a c.272 C>G mutation in exon 2 (p.L32V). Sural nerve biopsy revealed massive amyloid deposition in the perineurium, endoneurium and vasa nervorum. Mass spectrometric analyses of ATTR immunoprecipitated from nerve biopsy showed the presence of both wild‐type and variant proteins. The observed mass results for the wild‐type and variant proteins were consistent with the predicted values calculated from the genetic analysis data. The ATTR L32V is associated with a severe course. This has implications for treatment of affected individuals and counseling of family members.
Practice Patterns for Acute Ischemic Stroke Workup: A Longitudinal Population‐Based Study
Authors: Loftspring Matthew C. , Kissela Brett M. , Flaherty Matthew L. , Khoury Jane C. , Alwell Kathleen , Moomaw Charles J. , Kleindorfer Dawn O. , Woo Daniel , Adeoye Opeolu , Ferioli Simona , Broderick Joseph P. , Khatri Pooja 
Published: June 2017

Background
We examined practice patterns of inpatient testing to identify stroke etiologies and treatable risk factors for acute ischemic stroke recurrence.

Methods and Results

We identified stroke cases and related diagnostic testing from four 1‐year study periods (July 1993 to June 1994, 1999, 2005, and 2010) of the Greater Cincinnati/Northern Kentucky Stroke Study. Patients aged ≥18 years were included. We focused on evaluation of extracranial arteries for carotid stenosis and assessment of atrial fibrillation because randomized controlled trials supported treatment of these conditions for stroke prevention across all 4 study periods. In each study period, we also recorded stroke etiology, as determined by diagnostic testing and physician adjudication. An increasing proportion of stroke patients received assessment of both extracranial arteries and the heart over time (50%, 58%, 74%, and 78% in the 1993–1994, 1999, 2005, and 2010 periods, respectively;
P
<0.0001 for trend), with the most dramatic individual increases in echocardiography (57%, 63%, 77%, and 83%, respectively). Concurrently, we observed a decrease in strokes of unknown etiology (47%, 48%, 41%, and 38%, respectively;
P
<0.0001 for trend). We also found a significant increase in strokes of other known causes (32%, 25%, 45% and 59%, respectively;
P
<0.0001 for trend).

Conclusions
Stroke workup for treatable causes of stroke are being used more frequently over time, and this is associated with a decrease in cryptogenic strokes. Future study of whether better determination of treatable stroke etiologies translates to a decrease in stroke recurrence at the population level will be essential.
Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation
Authors: van Mens Thijs E. , Liang Hai-Po H. , Basu Sreemanti , Hernandez Irene , Zogg Mark , May Jennifer , Zhan Min , Yang Qiuhui , Foeckler Jamie , Kalloway Shawn , Sood Rashmi , Karlson Caren Sue , Weiler Hartmut 
Published: June 2017

Key PointsThrombomodulin deficiency in adult mice induces a fatal coagulopathy caused by the lack of cofactor function for activation of protein C. The severity of thrombosis after birth is modulated by in utero thrombomodulin expression in extraembryonic tissues.
Peer mentoring supports the learning needs of nurses providing palliative care in a rural acute care setting
Authors: Rabbetts Lyn 
Published: June 2017

Background: A specific set of assessment scales can underpin the management of distressing symptoms of patients requiring palliative care. A research assistant supported nurses working in a rural hospital setting during the introduction of these scales. Aim: A secondary analysis was conducted to further explore the qualitative data of a previously reported mixed-method study. In particular, the experiences of nurses working alongside a research assistant in the facilitation of using a new assessment form. Method: Purposeful sampling was employed: participating nurses were invited to attend one of three focus group meetings. Findings: Data analysis revealed three main themes: a contact person, coach/mentor and extra help initiatives. Three to four subthemes corresponded with each main theme. Conclusion: Findings suggest nurses benefit from having someone to assist in learning about new documentation. Nurses respond positively to mentorship and practical guidance when integrating a new assessment form into routine evidence-based practice.
Study of Fabricated Solar Dryer of Tomato Slices under Jordan Climate Condition
Authors: Olimat Abdullah Nasrallah 
Published: June 2017

The objective of the current study was to investigate experimentally, the performance of a fabricated solar dryer under Jordan climate condition during the summer of 2013. The temporal variations of temperature difference between absorber plate and ambient temperature were obtained in the results and its influence on the performance of solar flat plate collector was examined. The effects of absorber plate temperature, ambient temperature and wind heat transfer coefficient on the top heat loss coefficient were also investigated. The results showed that the efficiency of the collector ranging between 45 to 66 % which affected significantly by the amount of solar irradiation during the day. Only top heat loss was taken into considerations, since other losses were very small and might be negligible. Also the results confirmed that the performance of collector was maximum when the difference between plate and ambient temperatures was maximum. In addition, this work presented an indirect forced convection solar dryer, which consists of solar heater, fan and drying chamber. Fan was used to force the heated air through chamber to increase the drying rate. A 500 gram of tomatoes were dried to the final moisture content 28% from 95% (w.b). The experimental moisture ratios of the tomatoes were fitted to four mathematical drying models. Comparisons between these modes are sought using statistical analysis in the results. The fit quality obtained with each model was evaluated. After the comparison with the experimental obtained values, it was concluded that polynomial equation with second order represents the drying characteristics better than the other models by indicating high value of coefficient correlation (R2= 0.999564 ) and low values of other parameters( 𝞌2= 0.000203; RMSE= 0.01011; MBE= 0.000102 ) compare with other models. The effective moisture diffusivity was estimated using Fick's second law and was m2/s with an average temperature of 306 K.Article History: Received January 14th 2017; Received in revised form April 28th 2017; Accepted June 10th 2017; Available onlineHow to Cite This Article: Olimat, A.N. (2017) Study of Fabricated Solar Dryer of Tomato Slices Under Jordan Climate Condition. International Journal of Renewable Energy Development, 6(2), 93-101.https://doi.org/10.14710/ijred.6.2.93-101
Comparison of Dubowitz scoring versus Ballard scoring for assessment of fetal maturation of newly born infants setting
Authors: Singhal Sangeeta , Bawa Ritu , Bansal Shivani 
Published: June 2017

Background: Different scoring systems based on neurological and physical examination are used in the neonatal units for assessment of gestational age. Assessment of gestational age is very much helpful in labelling the newborn to be preterm, term or post – term and to assess the further outcome of the newborn infants. Present study was performed to test the accuracy and reliability of the Ballard scoring system as compared to Dubowitz scoring system on 250 newborn infants and their correlation with the gestational age as calculated from first day of mother’s last menstrual period. In infants of 38 weeks onwards correlation of gestational age was done with the extension of plantar creases over sole.Methods: Infants studied were selected from infants born in Muzaffarnagar Medical College and Hospital Muzaffarnagar and those infants admitted to the neonatal intensive care unit. First of all methods of eliciting different criteria were experienced by examining several newborn infants and then Dubowitz and Ballard scoring system were performed separately and gestational age assessed. crease was measured, using metallic scale from base of great toe after stretching the sole.Results: Gestational ages estimated by Ballard scoring system and Dubowitz system strongly correlated with the gestational ages computed from the date of mother’s last menstrual period. The coefficient of correlation calculated between Ballard and Dubowitz scoring system showed perfect positive correlation on the regression line. Association of gestational age with the length of sole crease was also very significant.Conclusions: The clinical test of maturation described by Ballard et al and which is evaluated in the present study, takes a balanced look at physical and neurological maturation and included those items found to be most useful regardless of the presence or absence of diseased state.
Thrombocytosis: can it be used as a marker for tuberculosis?
Authors: Rathod Suman , Samel Dinesh Ramesh , Kshirsagar Prasita , Pokar Muddasir 
Published: June 2017

Background: Tuberculosis is a major health problem in India. Early diagnosis and prompt treatment is the key to control this menace. Hence to improve diagnosis in peripheral region, it is imperative that other methods are used to supplement the diagnostic This study aimed at assessing the reactive thrombocytosis in patients with tuberculosis admitted in medicine ward of RGMC and CSMH, Kalwa, Thane, India.Methods: This study was conducted from 1st January 2016 up to 31st June 2016. Data was collected from the PM register and also from Post mortem records, entered in MS Excel and analyzed.Results: Newly discovered, 112 patients, diagnosed on basis of sputum AFB positivity, chest x-ray changes, pleural fluid, ascitic fluid and CSF analysis reports suggestive of tuberculosis were selected to be the cases, out of which 50 were males (44.6%) and 62 females (55.4%)and, 127 non-tuberculous patients admitted for other causes who did not have any symptoms or signs of tuberculosis were randomly selected to be the control group of the study. The ages of the patients ranged from 14 to 76 years old. Thrombocytosis was detected in 84 (75%)of the Tb patients, whereas only 3 (2.3%) in Non-Tb Patients. The erythrocyte sedimentation rate (ESR) was increased by more than 20 in 97.4% of the patients.Conclusions: The changes in these parameters (platelets count and ESR) may reflect a reaction to the inflammatory condition. Therefore, in endemic areas, the presence of such haematological peripheral blood changes may raise the suspicion of pulmonary tuberculosis.
Hearing impairment in rural area of Himalaya: prevalence and etiology
Authors: Guleria Trilok C. , Mohindroo Shobha , Azad Ramesh K. , Mohindroo Narender K. 
Published: June 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Hearing impairment is most frequent sensory deficit in human population. The disease burden estimations based on sound epidemiological research provide the foundation for appropriate public policy focus and measures for effective management of disease conditions. Data regarding the magnitude of hearing impairment in our country is limited and the literature search revealed that no such studies have been conducted in this region. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A community based cross sectional observational study was carried out among the 306 individuals in rural area of Shimla district, Himachal Pradesh. Information was obtained by a structured questionnaire, clinical ENT examination and audiological tests after obtaining informed consent. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">The study group had 52.6% males and 47.4% females. Maximum 26.5% of individuals were in the age group of 31-45 years. Mean age was 36.56±18.83. The prevalence of hearing impairment was 16.7%. Among individuals with hearing loss, maximum 52.9% were in the age group of ≥60 years. Sensorineural hearing loss was found in 68.6%, maximum 56.9% had mild hearing loss. Among majority of individuals with hearing loss cause was presbyacusis 52.9% followed by infectious ear disease 33.3%.</span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">In the present study, prevalence of hearing loss was found to be 16.7% and predominantly mild sensorineural or conductive type of hearing loss. An early intervention and quality patient education is necessary for prevention of hearing impairment in majority of cases.</span></p>
Correlation of HRCT mastoid with clinical presentation and operative findings in ear diseases
Authors: Chintale Sambhaji G. , Kirdak Vilas R. , Jatale Sonali P. , Shaikh Kaleem 
Published: June 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">HRCT is found to be extremely useful for evaluating the ear diseases involving the external auditory canal, middle ear cavity, vertical segment of facial nerve canal, vestibular aqueduct, tegmen tympani, sigmoid sinus plate, sinodural angle, carotid canal, jugular fossa, infra and supralabrynthine air cells and temporomandibular joint.<strong> </strong>Our main objective was to correlate the clinical presentation and operative findings of ear diseases with HRCT mastoid. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">This study is done in our institute otorhinolaryngology dept. from April 2014 to April 2016. This is prospective study involves 36 patient belonging to different age and sex groups with high suspicious of ear diseases. We have taken detail history of each patient with complete ear nose throat examination done and after that all patient were investigated with routine blood investigation, X-ray and HRCT mastoid to correlate clinical finding and subjected for operation to compare operative findings with HRCT finding. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Determined using Pearson chi square test indicated a statistically significant correlation between HRCT temporal bone with clinical presentation and operative findings of ear diseases (p&lt;0.05). </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">With the advent of modern high-resolution CT scanners, detailed demonstration of temporal bone anatomy is practically possible now. We have been able to identify many significant structures not demonstrated by any of the known imaging modalities. The improved contrast and soft tissue a definition possible with HRCT has resulted in production of excellent images of soft tissue lesions in air spaces. Hence HRCT appears to be the diagnostic modality of choice for cholesteatomas and other soft tissue lesions in middle ear.</span></p>
Clinical and audiological study of chronic suppurative otitis media tubotympanic type
Authors: G. Priyadarshini , Murali Sowmiya , James Febin 
Published: June 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Chronic suppurative otitis media (CSOM), tubotymapanic type, despite a commonly encountered disease in otorhinolaryngology has many controversies involved. This study was aimed at bringing few of these aspects to limelight. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The study was conducted in Otorhinolaryngology department, Aarupadai Veedu Medical College and Hospital, Pondicherry, India between September 2015 - August 2016. Total of 207 ears of 180 patients with CSOM tubotympanic type were included. Selected patients were subjected to ENT examination and pure tone audiometry after obtaining history. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">In this study 35.9% patients belonged to 4th decade and 29.4% to 3rd decade. Among patients with discharge for more than 30 years, 68.8% had moderately-severe hearing impairment and those with discharge for less than 10 years, 60.2% had mild hearing loss. Among patients with large central perforation, 51.4% had moderately-severe hearing loss and those with small central perforation, 68.4% had mild hearing loss. Hearing loss was nearly same in anterior and posterior perforations. On chi square test p value was 0.0874 i.e. &gt;0.05, difference insignificant. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">In our study most patients were in 4th decade, incidence is equal in both genders. Hearing loss is directly proportional to disease duration and perforation size. Site of perforation does not influence hearing loss.</span></p>
Parental perception of benefits from cochlear implantation in children with multiple impairments
Authors: Chavan Sumedha , Nandurkar Aparna 
Published: June 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Cochlear implantation (CI) in children with hearing impairment and an additional disability was not included in candidacy criteria earlier. With advances in technology and by taking into consideration the rehabilitation-pedagogic point of view, it is made possible to implant such children. In the Indian context, very few studies have documented benefits of CI in children with multiple impairments, whether measured or perceived by parents or families. Considering the number of children with additional impairments being implanted, it will be useful to conduct such a study, aimed at obtaining parents’ perceptions about benefits of cochlear implants in children with multiple impairments. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The present study is a survey of 31 children (3-15 years) using CI and having multiple disabilities. An ICF based questionnaire was developed and used to record parents’ perception of benefits in terms of language development, speech perception, social interaction, communication skills (non-verbal and verbal), education, general tasks and demands, interpersonal interactions and relationships and family dynamics. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Benefits were reported by all parents in all the domains i.e. listening, communication, learning and applying knowledge, interpersonal interactions and relationships and environmental factors. However, more parents reported consistent benefits in listening and interpersonal interactions. Most parents reported overall benefits from cochlear implantation in their children with multiple impairments. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Results of this study can be helpful in estimating outcomes from CI in children with multiple impairments. Such information can be used during pre-CI counselling to facilitate development of realistic parental expectations about the benefits of CI in their children with multiple impairments. As results are based on parental reports, overestimation of perceived benefits may be present in some instances.</span></p>
Combined endoscopic endonasal and subciliary approach in revision DCR cases
Authors: S. V. Manjunatharao , M. M. Rajshekar 
Published: June 2017

<p class="abstract"><strong>Background:</strong> Study conducted to know surgical outcome of combined endoscopic endonasal and subciliary approach in revision DCR cases and complications associated with the procedure.</p><p class="abstract"><strong>Methods:</strong> Prospective, single-blinded, randomized, interventional study is carried out in Tertiary level center from August 2009 to April 2016. Totally 18 patients (11 female and 7 male) were involved in the study who has undergone previous DCR (11 external DCR and 7 endoscopic DCR). The results were analyzed at end of the 3<sup>rd</sup> and 6<sup>th</sup> month both subjectively and objectively. </p><p class="abstract"><strong>Results:</strong> All the 18 patients who underwent combined approach were relived from epiphora. None of the patients developed any complications following surgery.</p><p><strong>Conclusions:</strong> The combination of endoscopic and external approach gives benefits of the both approaches giving huge advantages in revision cases. It gives excellent visualization of the surgical field, ability to correct internal nasal pathologies, make clear rhinostoma, workprecisely on fibrosed lacrimal sac and nearly no external scar. It provides good team work opportunity between otorhinologist and ophthalmologist.</p>
A comparative study of smartphone based app with free field hearing for possible use as a screening test
Authors: Swami Himanshu , Bhargava Aditya , K. Sabarigirish , M. Arvind B. 
Published: June 2017

<p class="abstract"><strong><span lang="EN-US">Background:</span></strong>Hearing loss is an invisible injury that has been viewed as an acceptable by-product of military service. It is imperative to detect hearing loss at early stage to take immediate remedial measures. In Indian armed forces the current method of assessment of hearing is primarily by Free Field Hearing which is obsolete and has numerous shortcomings. We contucted a study using free iOS application to detect hearing loss. The objectives of the study were to investigate the validity and reproducibility of app based hearing assement and free field hearing with clinical pure tone audiometer as gold standard. It is cross sectional intra-subject comparative study</p><p class="abstract"><strong><span lang="EN-US">Methods:</span></strong>The study was conducted at CHAF where 200 patients were accrued. Hearing assessment was carried out by Pure Tone Audiometry (PTA) which is gold standard. Thereafter these patients were subjected to hearing assessment by using windows application “freehearingtestsoftware.com” and by free field hearing (FFH). </p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong>Hearing assessment by FFH and hearing check app was compared with PTA. Hearing check app was found to be more sensitive than FFH (98% and 73%). Both modalities had high specificity (95% and 99%). The test retest reproducibility measured with Pearson correlation coefficient was high (0.99) with hearing check app.</p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong>Smart phone application like Hearing check app is a cheap and effective way to assess hearing with reasonable accuracy. It’s high sensitivity and high test retest reproducibility makes it an ideal tool for screening and early detection of hearing loss replacing out-dated free field hearing.</p><p class="abstract"><span lang="EN-US"> </span></p>