bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Stock Returns Really Decrease with Default Risk? New International Evidence
Authors: Aretz Kevin , Florackis Chris , Kostakis Alexandros 
Published: April 2017

This study constructs a novel data set of bankruptcy filings for a large sample of non-U.S. firms in 14 developed markets and sheds new light on the cross-sectional relation between default risk and stock returns. Using the reduced-form approach of Campbell et al. (2008) to estimate default probabilities, we offer conclusive evidence supporting the existence of a significant positive default risk premium in international markets. This finding is robust to different portfolio weighting schemes, data filters, risk-adjusting approaches, and holding period definitions. Decomposing the default risk measure into its systematic and idiosyncratic components, we find that the former drives this positive relation. We also show that the default risk premium is more pronounced in countries where creditor protection is stronger and shareholder bargaining power is lower. The online appendix is available at https://doi.org/10.1287/mnsc.2016.2712 . This paper was accepted by Amit Seru, finance.
Self-Regulation of an Unobservable Queue
Authors: Haviv Moshe , Oz Binyamin 
Published: April 2017

We consider an unobservable M/M/1 queue where customers are homogeneous with respect to service valuation and cost per unit time of waiting. It is well known that left to themselves, in equilibrium, customers join the queue at a rate higher than is socially optimal. Hence, regulation schemes, under which the resulting equilibrium joining rate coincides with the socially optimal one, should be considered. We suggest a classification of regulation schemes based on a few desired properties and use it to classify schemes from the existing literature. To the best of our knowledge, none of the existing schemes possesses all of the properties, and in this paper we suggest such a scheme. Its novelty is in assigning random priorities to customers, prior to their decision whether to join or balk. We also introduce variations of this regulation scheme as well as others that are also based on randomization. The e-companion is available at https://doi.org/10.1287/mnsc.2017.2728 . This paper was accepted by Gad Allon, operations management.
Optimal Dynamic Auctions for Display Advertising
Authors: Chen Ying-Ju 
Published: April 2017

In this paper, we investigate the optimal dynamic auction design for the display advertising industry. Currently, display advertising is sold through two markets side by side. In the traditional guaranteed market, the publisher commits to deliver a prespecified number of impressions within a fixed time frame through a guaranteed contract. In the spot market, the publisher runs an auction to allocate the impressions every period, and the supply of heterogeneous impressions is highly uncertain and nonstorable. Thus, the publisher must solve a dynamic capacity allocation problem of heterogeneous impressions across different contracts and markets, taking into account the uncertainties from both the demand and supply sides. We characterize the precise trade-offs between extracting the revenue from the spot markets, materializing the instantaneous benefit shared with the guaranteed advertisers, and releasing the pressure of paying the penalty related to guaranteed contracts. Furthermore, we identify the dual role of the publisher as a system designer and as a bidder on behalf of the guaranteed advertisers. With heterogeneous due dates of guaranteed contracts, we demonstrate the inherent scheduling issue embedded in this dynamic revenue management problem, and completely solve the joint scheduling and capacity allocation problem for some special cases. The online appendix is available at https://doi.org/10.1287/opre.2017.1592 .
Synovial calprotectin
Authors: Wouthuyzen-Bakker M. , Ploegmakers J. J. W. , Kampinga G. A. , Wagenmakers-Huizenga L. , Jutte P. C. , Muller Kobold A. C. 
Published: April 2017

Aims Recently, several synovial biomarkers have been introduced into the algorithm for the diagnosis of a prosthetic joint infection (PJI). Alpha defensin is a promising biomarker, with a high sensitivity and specificity, but it is expensive. Calprotectin is a protein that is present in the cytoplasm of neutrophils, is released upon neutrophil activation and exhibits anti-microbial activity. Our aim, in this study, was to determine the diagnostic potential of synovial calprotectin in the diagnosis of a PJI. Patients and Methods In this pilot study, we prospectively collected synovial fluid from the hip, knee, shoulder and elbow of 19 patients with a proven PJI and from a control group of 42 patients who underwent revision surgery without a PJI. PJI was diagnosed according to the current diagnostic criteria of the Musculoskeletal Infection Society. Synovial fluid was centrifuged and the supernatant was used to measure the level of calprotectin after applying a lateral flow immunoassay. Results The median synovial calprotectin level was 991 mg/L (interquartile range (IQR) 154 to 1787) in those with a PJI and 11 mg/L (IQR 3 to 29) in the control group (p < 0.0001). Using a cut-off value of 50 mg/L, this level showed an excellent diagnostic accuracy, with an area under the curve of 0.94. The overall sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) was 89%, 90%, 81% and 95% respectively. The NPV was 97% in the nine patients with a chronic PJI. Conclusion Synovial calprotectin may be a valuable biomarker in the diagnosis of a PJI, especially in the exclusion of an infection. With a lateral flow immunoassay, a relatively rapid quantitative diagnosis can be made. The measurement is cheap and is easy to use. Cite this article: Bone Joint J 2017;99-B:660–5.
Mass Spectrometry but Not Fluorimetry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease
Authors: Liao Hsuan-Chieh , Chan Min-Ju , Yang Chia-Feng , Chiang Chuan-Chi , Niu Dau-Ming , Huang Chun-Kai , Gelb Michael H 
Published: April 2017

AbstractBACKGROUNDDeficiency of the lysosomal enzyme acid α-glucosidase (GAA) causes Pompe disease. Newborn screening for Pompe disease is ongoing, and improved methods for distinguishing affected patients from those with pseudodeficiency, especially in the Asian population, would substantially reduce the number of patient referrals for clinical follow-up.METHODSWe measured the enzymatic activity of GAA in dried blood spots on newborn screening cards (DBS) using a tandem mass spectrometry (MS/MS) assay. The assay displayed a relatively large analytical range compared to the fluorimetric assay with 4-methylumbelliferyl-α-glucoside. DBS from newborns confirmed to have infantile-onset Pompe disease (IOPD, n = 11) or late-onset Pompe disease (LOPD) (n = 12) and those from patients bearing pseudodeficiency alleles with or without Pompe mutations, or Pompe disease carriers (n = 230) were studied.RESULTSWith use of the MS/MS GAA assay in DBS, 96% of the pseudodeficiency newborns and all of the Pompe disease carriers were well separated from the IOPD and LOPD newborns. The fluorimetric assay separated &lt;10% of the pseudodeficiencies from the IOPD/LOPD group.CONCLUSIONSThe relatively large analytical range MS/MS GAA assay but not the fluorimetric assay in DBS provides a robust approach to reduce the number of referrals and should dramatically facilitate newborn screening of Pompe disease.
Samurai masculinity, Japan’s self defence force and the uncanny space–time of Sengoku Jieitai
Authors: McKissack Fraser 
Published: April 2017

Abstract
The image of contemporary Japanese men fighting alongside samurai warriors is impossible, but not simply because time-travel does not exist. As I argue in this article, Japan is tethered to an historical narrative of samurai virtue that can no longer exist. This is a paradox that threatens to destabilize Japan’s contemporary military spaces and its contested history of militarism. I explore this paradox through the concept of Japan’s military space–time, which draws attention to the spatial and temporal dimensions of Japan’s demilitarization and the tensions that arise when a demilitarized space coexists with a militant history and the legacy of Japan’s epitomic masculine figure, the samurai. In order for contemporary Japanese SDF personnel to identify with the samurai they inevitably encounter the spectre of Japan’s twentieth–century militarism, and thus the samurai returns to the present as an uncanny embodiment of a repressed masculine self. Through the close analysis of two Japanese time-travel films, Sengoku Jieitai (Saitō, 1979) and Sengoku Jieitai: 1549 (Tezuka, 2005), I demonstrate how the attempt to reconcile Japan’s contemporary pacifist identity with its feudal past threatens to rupture the narrative of a cohesive national selfhood.
Total Anomalous Pulmonary Venous Connection in Children: Preoperative Evaluation with Low-Dose Multidetector Computed Tomographic Angiography
Authors: Turkvatan Aysel , Tola Hasan Tahsin , Ayyildiz Pelin , Ozturk Erkut , Ergul Yakup , Guzeltas Alper 
Published: April 2017

We report the results of our retrospective evaluation, from February 2011 through August 2014, of the anatomic features of total anomalous pulmonary venous connection (TAPVC) and its associated cardiovascular anomalies in a pediatric population. In all 43 patients under study (23 female; average age, 9 mo [range, 4 d–7.1 yr]), these examinations had been performed with a dual-source 256-detector scanner.
The type of TAPVC, the presence of obstruction, and the association with other cardiovascular anomalies were investigated and recorded. In accordance with the absence or presence of these accompanying anomalies, patients were subdivided into 2 groups: isolated and complex.
In the 43 patients, 22 (51%) TAPVCs were supracardiac, 10 (23%) were cardiac, 6 (14%) were infracardiac, and 5 (12%) were mixed. Obstruction was detected in 7 patients. Seventeen patients were in the isolated group and 26 in the complex group. The diagnostic agreements between multidetector computed tomographic angiographic and surgical results were 100% in both the isolated and complex groups. The overall average effective radiation dose was 0.66 mSv (range, 0.15–1.11 mSv); and it was 0.52 mSv (range, 0.12–0.72 mSv) in patients younger than 1 year of age.
We conclude that computed tomographic angiography with a dual-source 256-slice multidetector scanner is a reliable imaging method that enables, despite lower radiation doses, the detailed and comprehensive anatomic imaging of TAPVC in neonates and children.
Surgical Treatment of Constrictive Pericarditis
Authors: Depboylu Burak Can , Mootoosamy Parmeseeven , Vistarini Nicola , Testuz Ariane , El-Hamamsy Ismail , Cikirikcioglu Mustafa 
Published: April 2017

Constrictive pericarditis is the final stage of a chronic inflammatory process characterized by fibrous thickening and calcification of the pericardium that impairs diastolic filling, reduces cardiac output, and ultimately leads to heart failure.
Transthoracic echocardiography, computed tomography, and cardiac magnetic resonance imaging each can reveal severe diastolic dysfunction and increased pericardial thickness. Cardiac catheterization can help to confirm a diagnosis of diastolic dysfunction secondary to pericardial constriction, and to exclude restrictive cardiomyopathy.
Early pericardiectomy with complete decortication (if technically feasible) provides good symptomatic relief and is the treatment of choice for constrictive pericarditis, before severe constriction and myocardial atrophy occur.
We describe our surgical approach to constrictive pericarditis, summarize our results in 93 patients, and provide a brief overview of the literature.
A Rare Case of Vascular Ring and Coarctation of the Aorta in Association with CHARGE Syndrome
Authors: Wagner Jonathan B. , Knowlton Joshua Q. , Pastuszko Peter , Shah Sanket S. 
Published: April 2017

A male neonate presented with CHARGE syndrome, a multiorgan genetic disorder involving the Coloboma of the eyes, congenital Heart defects, nasal choanal Atresia, growth and development Retardation, Genitourinary disorders, and Ear anomalies and deafness. Moreover, he had a rare case of vascular ring—consisting of a right aortic arch with retroesophageal brachiocephalic artery—combined with coarctation of the mid-aortic arch. He underwent both vascular ring and aortic arch repair at our institution.
To our knowledge, this is the 4th documented case of this exceedingly rare type of aortic arch anomaly combined with aortic arch obstruction. Moreover, it is the first confirmed case of these combined disorders occurring in CHARGE syndrome.
This report describes a truly rare case and reveals the limitations of echocardiography in detecting complex aortic arch anomalies while illustrating the benefits of advanced imaging prior to surgical intervention.
Percutaneous Closure of 2 Paravalvular Leaks and a Gerbode Defect after Mitral Valve Replacement for Infective Endocarditis
Authors: Peñalver Jorge , Shatila Wassim , Silva Guilherme V. 
Published: April 2017

Surgical valve replacement after infective endocarditis can result in local destructive paravalvular lesions.
A 30-year-old woman with infective endocarditis underwent mitral valve replacement that was complicated postoperatively by 2 paravalvular leaks. During percutaneous closure of the leaks, a Gerbode defect was also found and closed. We discuss our patient's case and its relation to others in the relevant medical literature. To our knowledge, we are the first to describe the use of a percutaneous approach to close concomitant paravalvular leaks and a Gerbode defect.
Nina Braunwald: A Female Pioneer in Cardiac Surgery
Authors: Sabharwal Nikhil , Dev Harmanjit , Smail Hassiba , McGiffin David C. , Saxena Pankaj 
Published: April 2017

Nina Starr Braunwald, the first female cardiac surgeon, made headlines during a time when almost all specialty surgeons were men.
Women have typically been deterred from entering surgical specialties, in part because of their traditional dual burden of managing their households and careers. Instead, female medical students and junior doctors have tended to be more attracted to medical specialties. This was the reality during Dr. Braunwald's venture into medicine in 1949. However, she never allowed negative ideas to keep her from joining a surgical training program.
Under the mentorship of the prominent cardiac surgeons Charles Hufnagel and Andrew Morrow, Dr. Braunwald progressed in her career by conducting research that led to her development and implantation of the first prosthetic mitral valve. She was also a great teacher.
Dr. Braunwald balanced her personal and professional activities admirably, and her example still inspires female doctors to consider careers in cardiothoracic surgery. In this report, we provide details of her impact on cardiac surgery and insights into her successes.
Complexity classification of the edge coloring problem for a family of graph classes
Authors: Malyshev Dmitriy S. 
Published: April 2017

AbstractA class of graphs is called monotone if it is closed under deletion of vertices and edges. Any such class may be defined in terms of forbidden subgraphs. The chromatic index of a graph is the smallest number of colors required for its edge-coloring such that any two adjacent edges have different colors. We obtain a complete classification of the complexity of the chromatic index problem for all monotone classes defined in terms of forbidden subgraphs having at most 6 edges or at most 7 vertices.
On the asymptotic normality of some sums of dependent random variables
Authors: Tikhomirova Margarita I. , Chistjakov Vladimir P. 
Published: April 2017

AbstractA theorem on the asymptotic normality of the sum of dependent random variables is stated and proved. Conditions of the theorem are formulated in terms of a dependency graph which characterizes the relationships between random variables. This theorem is used to prove the asymptotic normality of the sum of functions defined on subsets of elements of the stationary sequence satisfying the strong mixing condition. As an illustration of possible applications of these theorems we give a theorem on the asymptotic normality of the number of empty cells if the random sequence of cells occupied by particles is a stationary sequence satisfying the uniform strong mixing condition.
Regulation of IRE1α by the small molecule inhibitor 4μ8c in hepatoma cells
Authors: Stewart Claire , Estrada Andrea , Kim Paul , Wang Dong , Wei Yuren , Gentile Chris , Pagliassotti Michael 
Published: April 2017

AbstractThe unfolded protein response (UPR) is activated in response to impairments of the folding environment in the endoplasmic reticulum (ER). The most conserved arm of the UPR, inositol-requiring ER-to-nucleus signaling protein (IRE1α), has been linked to the regulation of a diverse array of cellular processes including ER-associated degradation, inflammatory signaling, cell proliferation and membrane biogenesis. Recent studies have utilized the selective, small molecule inhibitor, 4μ8c, to examine the role of IRE1α endoribonuclease (RNase) activity in various cell types including multiple myeloma, mouse embryonic fibroblasts and pancreatic beta cells [1-5]. In the present study we utilized this inhibitor to examine the role of IRE1α RNase activity in hepatoma cells (H4IIE), specifically concentrating on cell proliferation and the identification of potential off target effects under both unstressed and stressed conditions. Experiments were performed in H4IIE hepatoma cells in the absence (control conditions (LG)) or presence (LG + Thapsigargin (Thap)) of ER stress. The presence of 4μ8c decreased IRE1α RNase activity, based on reduced splicing of X-box binding protein-1 (XBP1s) and regulated IRE1α-dependent decay of mRNA in both treatments and at concentrations ranging from 10-90 μM. Cell proliferation was significantly reduced at higher concentrations (> 60 μM 4μ8c) in unstressed cells and displayed a dose-response relationship with 4μ8c in both treatments. The presence of 4μ8c did not promote cytoxicity in either of the treatment conditions but higher concentrations of the inhibitor (60 μM) were associated with apparent off-target or compensatory responses that were not observed at 10 μM. Overall, the small-molecule inhibitor, 4μ8c is an effective inhibitor of IRE1α RNase activity in H4IIE cells. Potential off-target effects associated with this inhibitor require the use of multiple inhibitor concentrations in all experiments.
Median Analysis of Repeated Measures Associated with Recurrent Events in Presence of Terminal Event
Authors: Sundaram Rajeshwari , Ma Ling , Ghoshal Subhashis 
Published: April 2017

AbstractRecurrent events are often encountered in medical follow up studies. In addition, such recurrences have other quantities associated with them that are of considerable interest, for instance medical costs of the repeated hospitalizations and tumor size in cancer recurrences. These processes can be viewed as point processes, i.e. processes with arbitrary positive jump at each recurrence. An analysis of the mean function for such point processes have been proposed in the literature. However, such point processes are often skewed, leading to median as a more appropriate measure than the mean. Furthermore, the analysis of recurrent event data is often complicated by the presence of death. We propose a semiparametric model for assessing the effect of covariates on the quantiles of the point processes. We investigate both the finite sample as well as the large sample properties of the proposed estimators. We conclude with a real data analysis of the medical cost associated with the treatment of ovarian cancer.
Syntactically–driven algorithmic processing of PP-attachment ambiguity in a second language
Authors: Fukuta Junya , Aki Goto , Yusaku Kawaguchi , Akari Kurita , Daisuke Murota 
Published: April 2017

AbstractThis study explored whether Japanese EFL learners can utilize syntactically–driven algorithmic processing. For this purpose, the study attempted to inhibit other forms of processing (i.e., semantically–driven heuristic processing and processing with explicit knowledge) by using a self–paced reading task with priming of PP–attachment ambiguity. In the experiment, 20 highly proficient Japanese learners and 18 native speakers of English engaged in a phrase–by–phrase self–paced reading task after reading prime sentences. Although the results of non–native speakers (NNSs) showed a similar tendency to the NSs, there were slight differences between NSs and NNSs in terms of the size of the priming effects. This indicated that highly proficient Japanese EFL learners can utilize syntactically–driven algorithmic processing, but the process may be relatively “fragile” compared to that of NSs.
Equivalence of Lease and Tenancy Terminology in English and Lithuanian
Authors: Rackevičienė Sigita , Oleškevičienė Giedrė Valūnaitė , Galkutė Gabrielė 
Published: April 2017

Abstract
Prompted by globalization and the importance of international communication in the legal sphere, legal language acquires an increasing importance. Contract law draws special attention in the EU and worldwide, and raises a demand for harmonization of the legal terminology of different languages and legal systems. Contracts in Anglo- Saxon and Lithuanian law have similar basic elements; however, they also contain significant differences which are determined by the regulations of the legal systems in which contracts are formed. The terminology used in the contracts also presents important peculiarities. The article focuses on the terminology of lease and tenancy agreements and provides results of the contrastive semantic analysis, the aim of which is to establish the degree of equivalence of the collected English terms and their Lithuanian counterparts. All investigated English terms have synonyms, which makes the task even more complex, as most of such synonyms have certain semantic differences and may be used interchangeably only in certain contexts. The findings of the research are believed to be valuable to legal translators, as well as compilers of legal dictionaries and databases.
Capacities and Limitations of Wind Tunnel Physical Experiments on Motion and Dispersion of Different Density Gas Pollutants
Authors: Zavila Ondřej , Blejchař Tomáš 
Published: April 2017

AbstractThe article focuses on the analysis of the possibilities to model motion and dispersion of plumes of different density gas pollutants in lowspeed wind tunnels based on the application of physical similarity criteria, in this case the Froude number. The analysis of the physical nature of the modeled process by the Froude number is focused on the influence of air flow velocity, gas pollutant density and model scale. This gives an idea of limitations for this type of physical experiments in relation to the modeled real phenomena. The resulting statements and logical links are exemplified by a CFD numerical simulation of a given task calculated in ANSYS Fluent software.
A Design of Finite Memory Residual Generation Filter for Sensor Fault Detection
Authors: Kim Pyung Soo 
Published: April 2017

Abstract
In the current paper, a residual generation filter with finite memory structure is proposed for sensor fault detection. The proposed finite memory residual generation filter provides the residual by real-time filtering of fault vector using only the most recent finite measurements and inputs on the window. It is shown that the residual given by the proposed residual generation filter provides the exact fault for noisefree systems. The proposed residual generation filter is specified to the digital filter structure for the amenability to hardware implementation. Finally, to illustrate the capability of the proposed residual generation filter, extensive simulations are performed for the discretized DC motor system with two types of sensor faults, incipient soft bias-type fault and abrupt bias-type fault. In particular, according to diverse noise levels and windows lengths, meaningful simulation results are given for the abrupt bias-type fault.