bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Simple and Rapid UPLC-PDA Method for Quality Control of Nardostachys jatamansi
Authors: Zhang Weize , Nan Guo , Wu Hong-Hua , Jiang Miaomiao , Li Tian-Xiang , Wang Meng , Gao Xiu-Mei , Zhu Yan , Song Yun , Wang Jiaming , Xu Yan-Tong 
Published: December 2017

Abstract
Nardostachys jatamansi is a well-documented herbal agent used to treat digestive and neuropsychiatric disorders in oriental medicinal systems. However, few simple, rapid, and comprehensive methods were reported for quality assessment and control of N. jatamansi. Herein, a UPLC with photodiode array detection method was developed for both fingerprint investigation of N. jatamansi and simultaneous quantitative analysis of the six serotonin transporter modulatory constituents in N. jatamansi. For chromatographic fingerprinting, 24 common peaks were selected as characteristic peaks to assess the consistency of N. jatamansi samples from different retail sources. Six of the common peaks (5, 7, 12, and 16 – 18) were identified as desoxo-narchinol A, buddleoside, isonardosinone, nardosinone, kanshone H, and (−)-aristolone, respectively, by phytochemical investigation. Five of the six compounds significantly either enhanced or inhibited serotonin transporter activity, while (−)-aristolone (18) didnʼt show any serotonin transporter activity. In quantitative analysis, the six compounds showed good linearity (r > 0.999) within test ranges. The precision, expressed as relative standard deviation, was in the range of 0.25 – 2.77%, and the recovery of the method was in the range of 92 – 105%. The UPLC-photodiode array detection-based fingerprint analysis and quantitative methods reported here could be used for routine quality control of N. jatamansi.
Divergence of regulatory networks governed by the orthologous transcription factors FLC and PEP1 in Brassicaceae species
Authors: Mateos Julieta L. , Tilmes Vicky , Madrigal Pedro , Severing Edouard , Richter René , Rijkenberg Colin W. M. , Krajewski Paweł , Coupland George 
Published: December 2017

Significance
Developmental programs of higher plants show plasticity to environmental signals. In the Brassicaceae, the transcription factor (TF) FLOWERING LOCUS C (FLC) represses reproduction until plants are exposed to winter cold. Here we define the target genes of FLC in two species in different lineages of the Brassicaceae and compare the target sequences across the family. Fewer than 20% of target genes were conserved between the species examined, and genes involved in flowering were overrepresented among these. By contrast, many of the nonconserved target genes were involved in stress responses. We propose that, for TFs like FLC, which control environmental responses of plants, core sets of targets are conserved between species, but the majority change rapidly during evolution.
Dynamics of translation can determine the spatial organization of membrane-bound proteins and their mRNA
Authors: Korkmazhan Elgin , Teimouri Hamid , Peterman Neil , Levine Erel 
Published: December 2017

Significance
Unlike their eukaryotic counterparts, bacterial cells are composed of a single compartment. This allows many rapidly diffusing macromolecules, such as proteins and mRNAs, to be evenly distributed in the cell. Important exceptions are proteins embedded in the cell membrane, which transport material and information across the membrane. Often these proteins attach to the membrane before their translation is complete, anchoring their mRNAs to the vicinity of the membrane. This coupling between translation and localization suggests that the dynamics of translation may shape the spatial organization. In this paper, we use a canonical model of nonequilibrium statistical physics to characterize this connection and show how tunable kinetic properties allow the cell to regulate the spatial organization of both mRNAs and proteins.
Relationship between season of birth, temperature exposure, and later life wellbeing
Authors: Isen Adam , Rossin-Slater Maya , Walker Reed 
Published: December 2017

Significance
Recent work has demonstrated how exposure to extreme temperatures influences contemporaneous health outcomes, such as infant mortality and morbidity. Additional research has explored how shocks to the early-life environment affect long-run human capital outcomes. However, there is little evidence on the possible long-term consequences of exposure to extreme temperatures in utero or in early childhood. This paper begins to fill this gap by studying long-run effects of temperature on measures of individuals’ economic wellbeing around age 30 y. We find that adult economic outcomes are negatively correlated with prenatal exposure to days with mean temperatures exceeding 32 °C. This relationship is completely mitigated among individuals born in counties with high rates of access to air conditioning.
Naturalization of European plants on other continents: The role of donor habitats
Authors: Kalusová Veronika , Chytrý Milan , van Kleunen Mark , Mucina Ladislav , Dawson Wayne , Essl Franz , Kreft Holger , Pergl Jan , Weigelt Patrick , Winter Marten , Pyšek Petr 
Published: December 2017

Significance
Understanding which species become successful aliens outside their native range is a fundamental question in ecology, as it informs efforts to mitigate ecological and economic losses from biological invasions. For alien plants of European origin, the association with human-disturbed environments is suggested as a key factor for their establishment success following introduction to other regions, especially to similarly disturbed human-made habitats. By combining a comprehensive list of European habitats and their species composition with a database of plant naturalization records worldwide, we showed that a broad habitat range together with human-induced disturbance experienced in native-range habitats can increase a species’ chance of becoming naturalized in other parts of the world.
pH-sensitive vibrational probe reveals a cytoplasmic protonated cluster in bacteriorhodopsin
Authors: Lorenz-Fonfria Victor A. , Saita Mattia , Lazarova Tzvetana , Schlesinger Ramona , Heberle Joachim 
Published: December 2017

Significance
The vectorial transport of protons across membranes by pumps is central to cellular bioenergetics. A persistent problem in their study is the technical unfeasibility to simultaneously resolve the dynamics of all the relevant proton transfer steps by the same method, that is, those within the protein as well as those involving protonation changes of the aqueous medium, currently relying on complementary methods to map both. Here, we solved this limitation and monitored both internal and external protonation changes during the proton-pump mechanism of bacteriorhodopsin by time-resolved infrared spectroscopy. Our findings reveal inconsistencies with the proton uptake mechanism accepted for the last 25 years, highlighting the need for simultaneous and comprehensive monitoring of protonation changes to resolve the molecular mechanism of ion pumps.
Earliest hydraulic enterprise in China, 5,100 years ago
Authors: Liu Bin , Wang Ningyuan , Chen Minghui , Wu Xiaohong , Mo Duowen , Liu Jianguo , Xu Shijin , Zhuang Yijie 
Published: December 2017

Significance
The recently excavated Liangzhu hydraulic system in the Yangtze Delta has pushed back the date of formalized water engineering in China to approximately 5,100 years ago. The results are unprecedented in learning about the timing, structure, and function of a large-scale complex of dams, levees, ditches, and other water-controlling features in ancient China. Together with the well-excavated remains of Liangzhu city and its rice fields, the new findings represent one of the largest efforts of hydraulic landscape engineering in the ancient world.
Rapid diagnostic testing platform for iron and vitamin A deficiency
Authors: Lu Zhengda , O’Dell Dakota , Srinivasan Balaji , Rey Elizabeth , Wang Ruisheng , Vemulapati Sasank , Mehta Saurabh , Erickson David 
Published: December 2017

Significance
We demonstrate a technology that we believe could transform the way nutritional deficiency testing is done worldwide. Micronutrient deficiencies such as vitamin A and iron affect a third of the world’s population with consequences such as blindness, higher child mortality, anemia, poor pregnancy outcomes, and reduced work capacity. Our testing platform simultaneously quantifies concentrations of ferritin, retinol-binding protein, and C-reactive protein, allowing one to diagnose iron and vitamin A deficiency and inflammation status (to better inform and help with the interpretation of the result) in about 15 min. Our approach combines multiple florescent markers and immunoassay approaches on a single test strip, allowing us to span the five orders of magnitude difference in the physiological range of these markers.
Evaluating the environmental impacts of dietary recommendations
Authors: Behrens Paul , Kiefte-de Jong Jessica C. , Bosker Thijs , Rodrigues João F. D. , de Koning Arjan , Tukker Arnold 
Published: December 2017

SignificanceNationally recommended diets are a prominent method for informing the public on dietary choices. Although dietary choices drive both health and environmental outcomes, these diets make almost no reference to environmental impacts. Our study provides a comparison between the environmental impacts of average dietary intakes and a nation-specific recommended diet across 37 middle- and high-income nations. We find that following a nationally recommended diet in high-income nations results in a reduction in greenhouse gases, eutrophication, and land use. In upper-middle–income nations, we find a smaller reduction in impacts, and in lower-middle–income nations we find a substantial increase. The net result from large-scale adoption of nationally recommended diets for countries studied here results in a reduction in environmental impacts.
Musical training sharpens and bonds ears and tongue to hear speech better
Authors: Du Yi , Zatorre Robert J. 
Published: December 2017

Significance
Musical training is a good thing, but does it benefit us in hearing speech in noise as has been suggested? If so, what is the brain mechanism behind this? Here we provide evidence of musician advantage on speech in noise perception at not only the behavioral level but also the level of neural representations of phonemes and functional connectivity. Results implicate better speech encoding in both auditory and speech motor regions, as well as stronger cross-modal auditory–motor integration in musicians than nonmusicians when processing speech, especially in noisy conditions. The idea that musical training improves speech in noise perception by enhancing auditory–motor integration is intriguing, with applications in alleviating speech perception difficulties in aging populations and hearing disorders.
Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses,Strongyloides stercoralishyperinfection in NSG mice
Authors: Patton John B. , Bonne-Année Sandra , Deckman Jessica , Hess Jessica A. , Torigian April , Nolan Thomas J. , Wang Zhu , Kliewer Steven A. , Durham Amy C. , Lee James J. , Eberhard Mark L. , Mangelsdorf David J. , Lok James B. , Abraham David 
Published: December 2017

SignificanceThe intestinal parasiteStrongyloides stercoralisinfects an estimated 100 million people. This nematode’s unique ability to autoinfect its host enables it to persist for decades undetected and to progress to a potentially fatal hyperinfection that often is induced by glucocorticoid treatment. We report a mouse model, involving the NSG strain, that recapitulates all forms of human strongyloidiasis. Even in severely immunocompromised NSG mice, glucocorticoid treatment was required for autoinfection, raising intriguing questions about the mechanism of glucocorticoid action. Notably, administering a nematode-derived steroid, Δ7-dafachronic acid, which acts through a receptor withinS. stercoralisto regulate parasite development, significantly diminished autoinfection in glucocorticoid-treated NSG mice. This opens the possibility of new chemotherapy for hyperinfective strongyloidiasis, targeting the parasite’s own steroid hormone mechanisms.
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
Authors: Stone Meredith L. , Chiappinelli Katherine B. , Li Huili , Murphy Lauren M. , Travers Meghan E. , Topper Michael J. , Mathios Dimitrios , Lim Michael , Shih Ie-Ming , Wang Tian-Li , Hung Chien-Fu , Bhargava Vipul , Wiehagen Karla R. , Cowley Glenn S. , Bachman Kurtis E. , Strick Reiner , Strissel Pamela L. , Baylin Stephen B. , Zahnow Cynthia A. 
Published: December 2017

SignificanceTherapies that activate the host immune system have shown tremendous promise for a variety of solid tumors. However, in most cancer types, fewer than half of patients respond to these immunotherapies. We propose epigenetic therapy as a mechanism to sensitize tumors to immune checkpoint therapy. We have shown that inhibiting DNA methylation triggers a viral defense pathway in tumors. Here we show that epigenetic therapy in a mouse model of ovarian cancer increases the numbers of activated immune cells, and that this is dependent on the interferon antiviral response. The combination of epigenetic therapy and immune checkpoint blockade leads to the greatest reduction in tumor burden and increase in survival, and may hold the greatest promise for patients.
Extending density functional embedding theory for covalently bonded systems
Authors: Yu Kuang , Carter Emily A. 
Published: December 2017

Significance
Quantum mechanics (QM) simulations increasingly help researchers understand phenomena in chemistry, geoscience, material science, and biology. Unfortunately, the exact solution of the relevant QM equations is not available; consequently approximate yet accurate QM methods must be developed. In many situations, e.g., heterogeneous catalysis and enzymatic reactions, although the entire system is too large to treat with high-level QM, the relevant phenomena happen in a confined space. Quantum embedding theories can study exactly such cases by using highly accurate but expensive QM methods to simulate only the region of interest, while using fast but less accurate approximations to treat the surroundings. In this article, we present a unique, accurate quantum embedding theory applicable to covalently bonded systems.
Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings
Authors: Keahey Pelham A. , Simeral Mathieu L. , Schroder Kristofer J. , Bond Meaghan M. , Mtenthaonnga Prince J. , Miros Robert H. , Dube Queen , Richards-Kortum Rebecca R. 
Published: December 2017

Significance
Neonatal jaundice, a condition caused by the accumulation of bilirubin in the bloodstream, affects approximately half of all newborns. In high-resource settings, babies with elevated serum bilirubin levels are identified through routine hospital laboratory testing. When identified, jaundice is easily treated using blue-light phototherapy. Low-cost, rugged phototherapy lights have been developed and shown to be effective in low-resource settings. However, jaundice regularly goes undetected in these settings due to a lack of diagnostic tools to measure bilirubin levels. Left untreated, jaundice can lead to permanent neurological damage and mortality, the vast majority of which currently occurs in low-resource settings. In this paper, we present a low-cost method to measure total bilirubin at the point of care in low-resource settings.
TRPV1 is a physiological regulator of μ-opioid receptors
Authors: Scherer Paul C. , Zaccor Nicholas W. , Neumann Neil M. , Vasavda Chirag , Barrow Roxanne , Ewald Andrew J. , Rao Feng , Sumner Charlotte J. , Snyder Solomon H. 
Published: December 2017

Significance
MOR1, the main target of endogenous opioid peptides as well as morphine and other opiate derivatives, is a principal regulator of analgesia. TRPV1, the receptor for capsaicin, is increasingly recognized as a major mediator of mechanical, chemical, and thermal pain sensation. Here we demonstrate that these two pain systems, heretofore thought to operate independently, interact physically and physiologically. TRPV1 activation modulates MOR1 agonist-induced receptor phosphorylation via GRK5 and prevents MOR1 internalization from the cell membrane. TRPV1-mediated regulation of MOR1 thus affords a promising avenue to improve the therapeutic profile of opioid medications.
Strategic maneuvering by persuasive definition in corporate crisis communication
Authors: Na Yang 
Published: December 2017

Abstract
This paper aims to explore the use of persuasive definition in a corporate weblog by examining how a blogger attempts to define the company’s role in response to criticisms in the cyber space. Making use of a pragma-dialectical research framework, corporate weblog is characterized as an argumentative activity type in the commercial domain in which the legitimacy of persuasive definition is contextually constrained. The paper first analyzes the institutional preconditions that restrict all the argumentative moves in a corporate weblog, and then investigates how the corporate blogger of Taobao, the biggest online shopping website in China, responds to criticism by redefinition to evade the burden of proof.
A pragma-dialectical approach to governmental crisis communication
Authors: Linqiong Yan 
Published: December 2017

Abstract
To explore an argumentative approach to governmental crisis communication, this research adopts the pragma-dialectical framework to analyze and evaluate a local Chinese government’s crisis discourse concerning disputes over a proposed chemical project. The discourse is collected from the popular local online forum Mengxi Forum. By reconstructing from the discourse the four stages of a critical discussion, analyzing the embedded strategic maneuverings and evaluating the argumentation in view of institutional preconditions, it is shown that in its use of co-ordinative argumentation structures and causal argument schemes, the local government’s crisis discourse is not dialectically reasonable enough to convince the other stakeholders of the necessity to implement the proposed project. The results also shed some light on the necessity for governments’ crisis information management to ensure in its crisis discourse both dialectical reasonableness and rhetorical effectiveness.
A rhetorical approach to translation
Authors: Qian Duoxiu , Kaufer David 
Published: December 2017

AbstractOver the past three decades, the Chinese government has repeatedly called for the effective transmission of its policies to the West through translation. Yet the effectiveness of translation and its evaluation has remained a ticklish issue, particularly for texts with a political agenda. Fidelity to literal denotative meaning at the grain of words and phrases is generally insufficient for the translation of such texts. Texts in these sensitive domains of the Chinese context call for exacting fidelity in tone, register, genre, stance, connotation, and, overall, rhetoric. The Chinese government, wishing to avoid misinterpretation, is concerned with sharing their policies with foreigners as closely as possible to the way the many authors of these policies understood them from the inside. In this paper, we think of a “rhetoric” of translation holistically as capturing the “inside contours” of words and phrases as understood by a native speaker. For this purpose, we present a rhetorical approach to translation that can help explain the translation standards of Chinese government documents marked for wide-scale distribution abroad. The approach and method can be applicable in the assessment of other translations when rhetoric or the overall effect is the major concern.
Femtosecond Laser-Assisted Small Incision Endokeratophakia Using a Xenogeneic Lenticule in Rhesus Monkeys
Authors: He Miao , Jin He , He Hong , Ding Hui , Wang Wei , Liu Liangping , Zhang Chi , Zhong Xingwu 
Published: December 2017

Purpose:
To evaluate the feasibility and safety of xenogeneic endokeratophakia in rhesus monkeys and to explore the effects of a concave lenticule on refractive power.

Methods:
Three adult New Zealand white rabbits and 6 healthy rhesus monkeys were used. The xenogenic concave grafts were created from the rabbits using a modified small incision lenticule extraction technique; after being cryopreserved in glycerol for 1 week, the grafts were implanted into the monkey recipient corneas. Spherical equivalent (SE), central corneal thickness, and keratometry curvature were assessed preoperatively, 1 week, 1, 4 and 6 months postoperatively. The quality of the xenogenic graft was also assessed by slit-lamp microscopy, in vivo confocal microscopy, and optical coherence tomography with anterior segment imaging.

Results:
The graft appeared to be swollen a day after the operation but reduced considerably after a week. A trend of a lower refractive power (hyperopic shift) was demonstrated in relation to the SE after concave graft implantation. The mean SE increased from −0.60 ± 1.31 (median −0.69, interquartile range −1.00 to 0.50) preoperatively to 0.75 ± 1.27 (median 1.38, interquartile range −0.25 to 1.63) at 1 month postoperatively (P = 0.01). Central corneal thickness was significantly thicker each time after surgery compared with that recorded preoperatively (P < 0.01). The anterior and posterior interface between the graft and stroma was visible during the study. Corneal nerve regeneration was evident at 6 months postoperatively. The xenogeneic concave graft was stable and transparent at follow-up. Severe adverse events or evidence of a rejection response were not observed.

Conclusions:
Femtosecond laser-assisted small incision endokeratophakia using a xenogeneic corneal lenticule seems to be feasible and safe, which may provide a new method for myopia correction and keratoconus treatment.
Past Year Substance Use by Student Nurses
Authors: Boulton Martha A. , O’Connell Kathleen A. 
Published: December 2017

Abstract

Purpose:
Nurses who abuse substances are a threat to patients, colleagues, society, and themselves. Research indicates that substance use often begins during undergraduate years. The purpose of this research was to identify rates of past year substance use by student nurses.

Method:
A quantitative, cross-sectional, correlational design was used to examine past year substance use by student nurses and to determine whether substance use is related to age, gender, race, relationship status, ethnicity, country of birth, type of school program, and year in program. The convenience sample of National Student Nurses’ Association members yielded 4,033 completed surveys. Students were asked about their past year substance use via Survey Monkey. Responses were analyzed through exploratory data analysis and logistic regression.

Results:
Binge drinking was reported by 61% of the student nurses; 18% reported using marijuana; 5% reported using illegal drugs, excluding marijuana; 8% reported using nonprescribed stimulants to enhance academic performance; and 10% reported using nonprescribed prescription pills. Students who were younger than 28 years old, White, male, born in this country, or single tended to report more substance misuse than other students.

Conclusions:
The results suggest that student nurses tend to use fewer drugs than their college counterparts but are slightly more likely to binge drink. Further research is needed on the effect of substance education in the beginning of the nursing program and that continued throughout the program on student nurse substance use. Research on faculty’s ability to identify the at-risk student is necessary for early intervention.