bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to driving after a diagnosis of epilepsy: A prospective registry study
Authors: Xu Ying , Hackett Maree L. , Glozier Nick , Nikpour Armin , Somerville Ernest , Bleasel Andrew , Ireland Carol , Anderson Craig S. 
Published: January 2018

SummaryObjectiveTo determine the frequency and predictors of return to driving within 1 year after a diagnosis of epilepsy.MethodsSEISMIC (the Sydney Epilepsy Incidence Study to Measure Illness Consequences) was a prospective, multicenter, community‐wide study of people of all ages with newly diagnosed epilepsy in Sydney, Australia. Demographic, socioeconomic, and clinical characteristics and driving status were obtained as soon as possible after baseline registration with a diagnosis of epilepsy. Multivariate logistic regression was used to determine predictors of return to driving at 12‐month follow‐up.ResultsAmong 181 (76%) adult participants (≥18 years old) who reported driving before an epilepsy diagnosis, 152 provided information on driving at 12 months, of whom 118 (78%) had returned to driving. Driving for reasons of getting to work or place of education (odds ratio [OR] = 4.70, 95% confidence intervals [CI] = 1.87‐11.86), no seizure recurrence (OR = 5.15, 95% CI = 2.07‐12.82), and being on no or a single antiepileptic drug (OR = 4.54, 95% CI = 1.45‐14.22) were associated with return to driving (C statistic = 0.79). More than half of participants with recurrent seizures were driving at follow‐up.SignificanceEarly return to driving after a diagnosis of epilepsy is related to work/social imperatives and control of seizures, but many people with recurrent seizures continue to drive. Further efforts are required to implement driving restriction policies and to provide transport options for people with epilepsy.
Long‐term surveillance of SUDEP in drug‐resistant epilepsy patients treated with VNS therapy
Authors: Ryvlin Philippe , So Elson L. , Gordon Charles M. , Hesdorffer Dale C. , Sperling Michael R. , Devinsky Orrin , Bunker Mark T. , Olin Bryan , Friedman Daniel 
Published: January 2018

SummaryObjectiveLimited data are available regarding the evolution over time of the rate of sudden unexpected death in epilepsy patients (SUDEP) in drug‐resistant epilepsy. The objective is to analyze a database of 40 443 patients with epilepsy implanted with vagus nerve stimulation (VNS) therapy in the United States (from 1988 to 2012) and assess whether SUDEP rates decrease during the postimplantation follow‐up period.MethodsPatient vital status was ascertained using the Centers for Disease Control and Prevention's National Death Index (NDI). An expert panel adjudicated classification of cause of deaths as SUDEP based on NDI data and available narrative descriptions of deaths. We tested the hypothesis that SUDEP rates decrease with time using the Mann‐Kendall nonparametric trend test and by comparing SUDEP rates of the first 2 years of follow‐up (years 1‐2) to longer follow‐up (years 3‐10).ResultsOur cohort included 277 661 person‐years of follow‐up and 3689 deaths, including 632 SUDEP. Primary analysis demonstrated a significant decrease in age‐adjusted SUDEP rate during follow‐up (S = −27 P = .008), with rates of 2.47/1000 for years 1‐2 and 1.68/1000 for years 3‐10 (rate ratio 0.68; 95% confidence interval [CI] 0.53‐0.87; P = .002). Sensitivity analyses confirm these findings.SignificanceOur data suggest that SUDEP risk significantly decreases during long‐term follow‐up of patients with refractory epilepsy receiving VNS Therapy. This finding might reflect several factors, including the natural long‐term dynamic of SUDEP rate, attrition, and the impact of VNS Therapy. The role of each of these factors cannot be confirmed due to the limitations of the study.
Impact of pregnancy on psychoactive substance use among women with substance use disorders recruited in addiction specialized care centers in France
Authors: Pochard Liselotte , Dupouy Julie , Frauger Elisabeth , Giocanti Adeline , Micallef Joëlle , Lapeyre‐Mestre Maryse ,   French Addictovigilance Network
Published: January 2018

AbstractPregnancy can be a motivation for decrease in drug abusing but may also represent a period of high vulnerability for relapse. We aimed to assess psychoactive substance use among women with substance use disorders followed in addiction care centers in France. We analyzed data from women aged 15–44 years included in the ‘Observation of illegal drugs and misuse of psychotropic medication (OPPIDUM) survey’, an annual cross‐sectional survey collecting details on psychoactive substances used. Characteristics of women included in 2005–2012 yearly surveys were compared depending on their pregnant or not pregnant status. Factors, including pregnancy, associated with illicit substance use and medication misuse were investigated through logistic regression. The study included 518 pregnant and 6345 nonpregnant women; 85.3% pregnant women were on opioid maintenance therapy (OMT) (vs. 77.1% of nonpregnant). Pregnancy was associated with lower illicit substance use (adjusted OR 0.71 [0.58–0.88]) and with lower medication misuse (0.66 [0.49–0.89]), whereas financial insecurity and living as a couple were associated with increased risk. Raising children was significantly associated with less risk of substance use. Each substance taken separately, the part of women using illicit substance or misusing medication did not differ depending on whether they were pregnant or not, except for heroin (24.5% in pregnant vs. 17.9% nonpregnant; <0.001). This nationwide study provides new insights into psychoactive substance use in a large mixed population of women with drug use disorders. Results outline the challenge of preventing drug use and initiating care strategies with a specific approach on socio‐economic environment.
Virginia mallow (Sida hermaphrodita (L.) Rusby) as perennial multipurpose crop: biomass yields, energetic valorization, utilization potentials, and management perspectives
Authors: Nahm Michael , Morhart Christopher 
Published: January 2018

AbstractThis article reviews the scholarly literature dealing with the perennial multipurpose crop Virginia mallow (Sida hermaphrodita (L.) Rusby; Sida in the following). In regions dominated by intensive agricultural management practices, growing Sida holds the potential to combine ecosystem services such as decreasing soil erosion, reducing nitrate leaching as well as enhancing biodiversity, with economic profit for the farmer. After promising biomass yields of Sida were reported from studies performed in Poland about 15 years ago, the interest in this plant species has continuously increased, and different utilization pathways were examined, predominantly by researchers in Poland and Germany. At present, however, a comprehensive overview that summarizes the different lines of research performed regarding the use of Sida is lacking. This review aims at closing this gap. After providing background information on Sida, we summarize the main results obtained from investigations concerning biomass yields, fertilization effects, key findings concerning direct combustion, biogas production, steam gasification, phytoremediation, and alternative utilization pathways. Thereafter, we highlight important aspects of Virginia mallow cultivation practices, including first estimates regarding the costs involved. Finally, we point to existing research gaps. Summarizing the available literature on Sida, we aim at raising the interest of scientists and farmers in this plant species further and to show where future research might tie in with, as the successful cultivation of Sida might represent a worthwhile strategy to transform current agricultural practices in Central Europe into approaches that are more sustainable and resilient against future challenges.
Evaluating the validity of subclassifying warfarin‐associated nonuremic calciphylaxis: a retrospective cohort study
Authors: Lehman Julia S. , Chen Tiffany Y. , Lohse Christine M. , el‐Azhary Rokea A. 
Published: January 2018

AbstractBackgroundCalciphylaxis is a devastating multifactorial disorder of the subcutaneous fat that is known to be associated with hypercoagulability. Recent literature has proposed subclassifying patients with calciphylaxis as having warfarin‐associated or warfarin‐unassociated disease.AimWe aimed to determine whether patients with warfarin‐associated calciphylaxis differ clinically from patients with warfarin‐unassociated calciphylaxis.Materials and methodsWe performed a subgroup analysis of patients with nonuremic calciphylaxis from a previously studied cohort and compared clinical and outcomes features of patients who were taking warfarin at the time of disease onset to those of patients who were not.ResultsNineteen patients with nonuremic calciphylaxis were identified, including 10 (53%) who had been on warfarin at the time of disease onset and 9 (47%) who had not. Of all clinical and outcomes parameters tested, no significant differences were detected between the two groups.Discussion and ConclusionsThough this study is limited by its retrospective nature and the relatively small number of patients studied, available data do not support subclassifying patients with nonuremic calciphylaxis as having warfarin‐associated or warfarin‐unassociated disease. Rather, the body of literature would suggest that identification and correction of underlying disorders of hypercoagulability should be prioritized.
Physicochemical, functional andATR‐FTIR molecular analysis of protein extracts derived from starchy pulses
Authors: de la Rosa‐Millán Julián , Orona‐Padilla José Luis , Flores‐Moreno Víctor Manuel , Serna‐Saldívar Sergio O. 
Published: January 2018

SummaryAn alkaline solubilisation and isoelectric point precipitation process were used to isolate proteins from broad bean, chickpea, lentil and white bean. The physicochemical, water solubility and foaming properties as well as their protein digestion characteristics of whole flours and its protein extracts were correlated with their molecular characteristics, analysed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR). The processing of pulses resulted in protein recoveries ≥50.12% and yields up to 30.26% for broad bean. The purity of the protein was from 68.27% to 86.58% for chickpea and broad bean, with in vitro digestion values ≥80.59%. The protein extracts showed up to 0.85 mg g−1 of phenolic compounds (gallic acid eq./100 g). The ATR‐FTIR analysis of the extracts showed different proportions of α‐helix and β‐sheet secondary structures of the amide II group. The analysis of the amide III group reflected inter‐ and intramolecular associations that could have influenced their emulsion and foam characteristics.
Expectations and experiences of patients with osteoarthritis undergoing total joint arthroplasty: An integrative review
Authors: See Min Ting Alicia , Kowitlawakul Yanika , Tan Apphia Jia Qi , Liaw Sok Ying 
Published: January 2018

AbstractBackgroundThe effectiveness of educational interventions for osteoarthritic patients undergoing total joint arthroplasty remains inconclusive. It is essential to understand the educational needs of these patients from their perspectives.AimThe aim of this study was to systematically summarize and synthesize osteoarthritic patients' expectations and experiences in undergoing total joint arthroplasty to identify their educational needs.DesignAn integrative review was conducted.MethodsTwenty studies (13 qualitative and 7 quantitative), published between 2006 and 2016, were independently appraised by 2 reviewers using the Critical Appraisal Skills Programme checklist for qualitative studies and the Joanna Briggs Institute Critical Appraisal Tools for quantitative studies. Data were analysed using thematic analysis, and the findings were synthesized in a narrative summary.ResultsSix themes describing patients' preoperative and post‐operative educational needs were identified: (1) preoperative anxiety, (2) unrealistic expectations of recovery, (3) post‐operative pain, (4) regaining functional abilities, (5) physical and psychological sense of loss, and (6) lack of continuity of care.ConclusionThis review is the first to capture the osteoarthritic patients' educational needs from their perspectives. The biopsychosocial model can address the multidimensionality (biological, psychological, and social) of patients' educational needs. A robust infrastructure supporting interprofessional collaborative practice and continuity of care should be adopted to enhance current educational efforts.
Hypoxia‐inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues
Authors: Ebersole Jeffrey L. , Novak Michael John , Orraca Luis , Martinez‐Gonzalez Janis , Kirakodu Sreenatha , Chen Kuey C. , Stromberg Arnold , Gonzalez Octavio A. 
Published: January 2018

SummaryHypoxia (i.e. oxygen deprivation) activates the hypoxia‐signalling pathway, primarily via hypoxia‐inducible transcription factors (HIF) for numerous target genes, which mediate angiogenesis, metabolism and coagulation, among other processes to try to replenish tissues with blood and oxygen. Hypoxia signalling dysregulation also commonly occurs during chronic inflammation. We sampled gingival tissues from rhesus monkeys (Macaca mulatta; 3–25 years old) and total RNA was isolated for microarray analysis. HIF1A, HIF1B and HIF2A were significantly different in healthy aged tissues, and both HIF1A and HIF3A were positively correlated with aging. Beyond these transcription factor alterations, analysis of patterns of gene expression involved in hypoxic changes in tissues showed specific increases in metabolic pathway hypoxia‐inducible genes, whereas angiogenesis pathway gene changes were more variable in healthy aging tissues across the animals. With periodontitis, aging tissues showed decreases in metabolic gene expression related to carbohydrate/lipid utilization (GBE1, PGAP1, TPI1), energy metabolism and cell cycle regulation (IER3, CCNG2, PER1), with up‐regulation of transcription genes and cellular proliferation genes (FOS, EGR1, MET, JMJD6) that are hypoxia‐inducible. The potential clinical implications of these results are related to the epidemiological findings of increased susceptibility and expression of periodontitis with aging. More specifically the findings describe that hypoxic stress may exist in aging gingival tissues before documentation of clinical changes of periodontitis and, so, may provide an explanatory molecular risk factor for an elevated capacity of the tissues to express destructive processes in response to changes in the microbial biofilms characteristic of a more pathogenic microbial challenge.
Soil urease and catalase responses to ozone pollution are affected by the ozone sensitivity of wheat cultivars
Authors: Kou T.‐J. , Lam S.K. , Chen D.‐L. , Yu W.‐W. 
Published: January 2018

AbstractUnderstanding the effects of elevated O3 (EO3) on belowground process such as soil enzyme activities is essential to evaluate plant physiological reaction and soil processes (e.g. carbon and nitrogen turnover) under predicted increases in atmospheric O3. In this study, O3‐induced changes in soil urease (UA) and catalase activities (CTA) under two contrasting wheat cultivars (O3‐sensitive versus O3‐tolerant) were investigated using a free‐air O3 enrichment (O3FACE) facility in China. EO3 (60 ppb compared with 40 ppb in ambient O3) generally increased UA under the O3‐tolerant cultivar but reduced it under the O3‐sensitive cultivar for different soil depths and growth stages. In contrast, the effects of EO3 on CTA were not consistent and varied with soil depths and growth stages. These results suggest that the O3 sensitivity of wheat cultivars plays an important role in determining the effects of EO3 on soil enzyme activities. The contrasting responses of soil UA and CTA to EO3 may alter the effect of projected increase in tropospheric O3 on soil carbon and nitrogen turnover.
The exaggerated blood pressure response to exercise in the sub‐acute phase after stroke is not affected by aerobic exercise
Authors: Wijkman Magnus O. , Sandberg Klas , Kleist Marie , Falk Lars , Enthoven Paul 
Published: January 2018

The prevalence of an exaggerated exercise blood pressure (BP) response is unknown in patients with subacute stroke, and it is not known whether an aerobic exercise program modulates this response. The authors randomized 53 patients (27 women) with subacute stroke to 12 weeks of twice‐weekly aerobic exercise (n = 29) or to usual care without scheduled physical exercise (n = 24). At baseline, 66% of the patients exhibited an exaggerated exercise BP response (peak systolic BP ≥210 mm Hg in men and ≥190 mm Hg in women) during a symptom‐limited ergometer exercise test. At follow‐up, patients who had been randomized to the exercise program achieved higher peak work rate, but peak systolic BP remained unaltered. Among patients with a recent stroke, it was common to have an exaggerated systolic BP response during exercise. This response was not altered by participation in a 12‐week program of aerobic exercise.
Impact of quality of research on patient outcomes in the Institute of Medicine 2013 report on dietary sodium
Authors: Lucko Aaron , Doktorchik Chelsea TA , Campbell Norm RC 
Published: January 2018

The 2013 Institute of Medicine report entitled “Sodium Intake in Populations: Assessment of Evidence” found inconsistent evidence of health benefit with dietary sodium intake <2300 mg/d. Different studies reported benefit and harm of population dietary intake <2300 mg/d. The Institute of Medicine committee, however, did not assess whether the methodology used in each of the studies was appropriate to examine dietary sodium and health outcomes. This review investigates the association of methodological rigor and outcomes of studies in the Institute of Medicine report. For the 13 studies that met all methodological criteria, nine found a detrimental impact of high sodium consumption on health, one found a health benefit, and in three the effect was unclear (P = .068). For the 22 studies that failed to meet all criteria, 11 showed a detrimental impact, four a health benefit, and seven had unclear effects from increasing dietary sodium (P = .42).
The association between different features of sleep‐disordered breathing and blood pressure: A cross‐sectional study
Authors: Khoshkish Shayan , Hohl Mathias , Linz Benedikt , Arzt Michael , Mahfoud Felix , Baumert Mathias , Schöpe Jakob , Böhm Michael , Linz Dominik 
Published: January 2018

Sleep disordered breathing (SDB) is highly prevalent in patients with high blood pressure (BP). Severity of SDB can be evaluated by the number of apneas and hypopneas per hour (AHI) or by measures of hypoxia. The objective of this study was to assess the association between different measures of SDB and BP. In 134 consecutive patients, polygraphy was performed to determine the AHI. Pulse oximetry was used to determine hypoxemic burden (time below 90% oxygen saturation [T90] and hypoxia load [HL], representing the integrated area above the curve of desaturation). AHI did not correlate with systolic and diastolic BP or pulse pressure. In contrast, HL correlated with pulse pressure during the day (P = .01) and night (P = .0034) before and after adjustment for body mass index. The correlation between systolic BP and HL at night disappeared following adjustment for body mass index. This study generates the hypothesis that nocturnal hypoxemic burden may represent a suitable marker of BP pattern and a potential treatment target in hypertensive patients.
Reflectance confocal microscopy and optical coherence tomography for the diagnosis of bullous pemphigoid and pemphigus and surrounding subclinical lesions
Authors: Mandel V.D. , Cinotti E. , Benati E. , Labeille B. , Ciardo S. , Vaschieri C. , Cambazard F. , Perrot J.L. , Pellacani G. 
Published: January 2018

AbstractBackgroundDiagnosis of bullous pemphigoid (BP) and pemphigus is based on clinical features, histology, immunofluorescence and laboratory data.ObjectivesTo evaluate features of BP and pemphigus at reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in order to provide a rapid non‐invasive bed‐side diagnosis. Secondary objective was to evaluate the detectability of clinically non‐visible lesions.MethodsThis was an observational, retrospective, multicentre study in which patients with suspicious lesions for BP or pemphigus underwent clinical assessment, RCM, OCT, blood tests and skin biopsy for histological and direct immunofluorescence examinations from January 2014 to December 2015. A total of 72 lesions in 24 selected patients were evaluated. Additionally, apparently unaffected skin at two different distances [near (1–2 cm) and far (2–3 cm)] from each lesion was examined to test subclinical lesion detectability.ResultsRCM was able to detect subepidermal and intra‐epidermal blisters, respectively, in 75% and 50% of the patients affected by BP and pemphigus. At OCT, the exact blister level was identified in all patients. Acantholytic cells were observed only at RCM in pemphigus (62.5%). Fibrin deposition inside the blisters was only found in BP, evidenced both at RCM and OCT. Among patients with BP, subclinical blisters were detected in nine (9.4%) clinically healthy skin, while among patients with pemphigus were observed in 10 (20.8%) apparently unaffected skin.ConclusionRCM and/or OCT provide useful information for a rapid diagnosis of BP and pemphigus and for the identification of biopsy site. Combined use of RCM and OCT is optimal because associates the higher resolution of RCM with the greater penetration depth of OCT. OCT could be an optimal tool for treatment monitoring, especially in the cases of subclinical lesions. However, histopathologic and immunologic examinations remain the gold standard for establishing the final diagnosis.
Casual movement speed but not maximal locomotor capacity predicts mate searching success
Authors: Kasumovic M. M. , Seebacher F. 
Published: January 2018

AbstractMaximal locomotor performance is often used as a proxy for fitness. Maximal speed may be important under high‐threat conditions, such as during predator escape. However, animals do not always move at a speed that reflects their maximal physiological capacities when undisturbed. The physiological factors that determine the movement speed chosen by animals, such as minimization of energy use, may be independent from maximal performance. As a result, the casual speed at which individuals move when undisturbed in a given context may better represent an individual's motivation to move. The casual speed may therefore be a better predictor of fitness in natural contexts than maximal performance capacity. We tested the hypothesis that casual movement speed rather than maximal speed predicts fitness in the golden orb‐web spider, Nephila plumipes. We measured fitness in two separate contexts, mate‐searching success and the positional rank near a female. We show that casual but not maximal locomotor speed predicted both aspects of fitness. Casual speed was linearly related to maximal speed, indicating that casual speed is determined by physiological optimization. Size and metabolic scope were not related to either maximal or chosen speeds, indicating that the supply of ATP does not limit locomotor performance in this species. Overall, our results demonstrate that locomotor performance is related to fitness, but suggest that different types of performance and not necessarily maximal physiological capacities are most relevant for particular ecologically relevant tasks.