bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: Is It a Valid Treatment Option?
Authors: Mondello Patrizia , Steiner Normann , Willenbacher Wolfgang , Ferrero Simone , Ghione Paola , Marabese Alessandra , Pitini Vincenzo , Cuzzocrea Salvatore , Mian Michael 
Published: July 2016

AbstractBackground.Despite the advent of new treatment strategies, many patients with diffuse large B-cell lymphoma (DLBCL) relapse or die of the disease. Prospective clinical trials have demonstrated that lenalidomide is an effective and safe treatment option, especially for non-germinal center B-cell (non-GCB) DLBCL. However, routine clinical data are lacking, which is why we provide the results of the so-far largest relapsed/refractory (R/R) DLBCL real-life analysis.Methods.We retrospectively assessed 123 R/R DLBCL patients who received either 15 or 25 mg/day of lenalidomide from January 2006 to January 2015.Results.During a median follow-up period of 4.5 years, complete remission was achieved in 32% and a partial remission in 33% non-GCB patients compared with 0% and 3% in the GCB group (p &lt; .001 and .001, respectively), with median response durations of 15 and 5 months, respectively (p &lt; .001). Lenalidomide at 25 mg was superior to 15 mg in terms of response (complete remission 21% and partial remission 23% vs. 0% and 8%; p = .007 and .05) and median response duration (10 vs. 4 months; p = .03). Toxicity was limited and reversible. Median progression-free survival differed between non-GCB and GCB patients (37 vs. 30 months; p &lt; .001) and between the two dosages (24 vs. 34 months; p = .002). However, overall survival was similar between the subgroups (38–42 months).Conclusion.We provide evidence that lenalidomide is a valid treatment option for R/R DLBCL, with limited and reversible toxicity, and is more efficient in non-GCB DLBCL and at higher doses.
A Corpus-based Study on Chinese EFL Learners' Acquisition of English Existential Construction
Authors: Zhang Xiaorong 
Published: July 2016

This corpus-based study examines English existential construction used by intermediate and advanced level Chinese EFL (English as a Foreign Language) learners. The corpora adopted are the sub-corpora of SWECCL2.0—TEM 4 Oral and TEM 8 Oral and a sub-corpora of COCA. The study concludes Chinese EFL learners tend to overuse English existential construction and prefer the basic tenses, simple intransitive verbs and commonly seen expressions, avoid the perfect tenses and the difficult forms. With the level of proficiency in English getting higher, Chinese students try to use fewer English existential sentences. The study also finds errors relevant to the tenses, agreements and misuse of “there + have” pattern made in TEM 4 Oral and more difficult participle errors made in TEM 8 Oral and the main reason of errors made in English existential acquisition is due to L1 transfer/ L1 influence
A multidisciplinary approach for the treatment of complication of hematogenous osteomyelitis in children
Authors: Garkavenko Yury Garkavenko , Semyonov Mikhail G , Troschieva Darya О 
Published: July 2016

Background.Severe orthopedic complications of osteomyelitis occurred in 22%–71.2% of children with osteomyelitis in previous studies. At the same time 26.5% of children with complications of osteomyelitis, according to data of The Turner Scientific and Research Institute for Children’s Orthopedics, have multiple bone lesions. The challenges involved in the orthopedic treatment of musculoskeletal system disorders are diverse and complex. In some cases, inadequate attention is paid to the need to treat the facial bones of the skull, temporomandibular joint (TMJ), and jaw bones.Aim.The aim of this paper is to demonstrate the need for a variety of options and to determine the best strategies for comprehensive medical rehabilitation, involving orthopedic and maxillofacial surgeons and other healthcare providers, for children with complications of osteomyelitis, who had destruction of the long tubular bones of the jaw.Materials and methods.Between 2011 and 2015 26 children (10 males and 16 females) aged 1.5–17 years with multiple localized lesions after osteomyelitis were treated in The Turner Scientific and Research Institute for Children’s Orthopedic. In addition to severe orthopedic disorders, there has been a loss of TMJ, which resulted in severe functional impairment and impaired development of the facial bones of the skull.Results.There was a individualized approach to the treatment of pediatric patients with complications of osteomyelitis. Early diagnosis and proper treatment prevented severe changes in the musculoskeletal system and maxillofacial area in pediatric patients.Conclusion.The modern concept of comprehensive medical rehabilitation of children with complications of osteomyelitis should include an interdisciplinary approach involving orthopedic and maxillofacial surgeons. Early diagnosis in children ensures the timely formation of individualized rehabilitation programs, designed to improve the anatomical and functional characteristics of the affected bones. Along with comprehensive orthopedic treatment, bone-reconstructive surgery of the facial bones of the skull should be focused on restoration of chewing function, external respiration, speech, and facial esthetics.
Parents' and Professionals' Perceptions towards Support for Children with Communication Disorders in Preschool Settings in the North West Bank in Palestine: Preliminary data from the pilot study
Authors: Jarrar Hala , Mundus Erasmus 
Published: July 2016

According to the Palestinian Centre for Statistics (2013), children with communication disorders constitute the highest percentage of special educational needs in Palestine; however, there is a lack of services to support these children. The purpose of this quantitative study is to analyze how the preschools settings (private and public) in the Northern region of the West Bank, Palestine, which contains these cities and towns (Nablus, Jenin, Qalqilya, Qabatiya, Tulkarem, Salfeet, and Tubas), support children with communication disorders from the parents' and professionals' perceptions ( preschool teachers and specialists such as physiotherapists, speech and language therapists, psychologists, etc). To collect data, two questionnaires were developed, one for parents, and the other for professionals. The participants in this study were 40 parents and 44 professionals from all these regions. The researcher aimed to clarify the type of support provided for children with communication disorders in preschool contexts in Palestine, also to find out if there is a relationship between the variables of the study (gender, age, professional experience, etc) and the perceptions of parents and professionals towards the support provided in preschool settings. Preliminary data from this study will be provided.
Relaciones entre el conocimiento conceptual y el procedimental en el aprendizaje de las fracciones
Authors: Andrés María Laura , Canet-Juric Lorena , Introzzi Isabel , Stelzer Florencia , Urquijo Sebastián 
Published: July 2016

<p>El objetivo de este trabajo fue analizar las relaciones entre el conocimiento conceptual y el procedimental de las fracciones durante su aprendizaje. Para esto se efectuó una búsqueda bibliográfica en las bases de datos ERIC, PsycInfo, Scielo y Redalyc, con los siguientes términos en español y sus equivalentes en inglés: fracciones (fractions), conocimiento conceptual (conceptual knowledge), conocimiento procedimental (procedural knowledge) y niños (children), combinados de diferente forma con el operador booleano AND (Y). Los resultados de esta búsqueda permitieron hallar quince artículos empíricos que pueden clasificarse en cuatro grupos de investigaciones: las que indican una relación bidireccional, las que sugieren una relación unidireccional, las que muestran cierta independencia o restricciones en su vinculación y, por último, las que señalan que las relaciones varían según los sujetos. Esta falta de acuerdo podría explicarse por ciertas diferencias metodológicas de los estudios, por ejemplo, diferencias en el grado de consolidación del conocimiento de las fracciones de los participantes, el sentido conceptual o la habilidad procedimental estudiada, el tipo de enseñanza matemática recibida, etc. Por ello se sugiere que, para profundizar la comprensión de las relaciones entre el conocimiento conceptual y procedimental de las fracciones, estos aspectos metodológicos deben ser controlados. </p>
Repatriados brasileiros de transnacionais: fatores relevantes para sua permanência
Authors: Walter Silvana Anita , Frega José Roberto 
Published: July 2016

Este estudo objetivou analisar os fatores relevantes para a permanência dos repatriados nas organizações. Aplicou-se um questionário a 20 repatriados de 11 transnacionais. Empregaram-se análises multicritério e de conteúdo. O método multicritério empregado é inovador por utilizar uma ferramenta inédita à investigação do espaço de soluções de problemas de decisão do tipo em um estudo empírico. Identificou-se que as variáveis que mais contribuem para a permanência estão relacionadas à carreira, à função e suas características (autonomia e tarefas), e ao padrão de vida dos repatriados. Percebe-se que as organizações precisam aperfeiçoar a administração dos processos de expatriação e repatriação.
GLOBALIZAÇÃO E COSMOPOLISMO: CONTROVÉRSIAS KANTIANAS DO DIREITO DOS POVOS
Authors: Heck José N. 
Published: July 2016

Kant distingue entre direito estatal, direito dos povos e direito cosmopolita. O presente artigo expõe o princípio moral do cosmopolitismo kantiano e a proposta discreta de cosmopolitismo político do filósofo alemão. O trabalho destaca a posição cosmopolita kantiana sob o pano de fundo do internacionalismo que propõe uma versão planetária de sociedade civil (J. Habermas) e do jusnaturalismo que defende a figura de um cidadão do mundo ao lado das cidadanias nacionais (O. Höffe). O texto procura fazer jus ao anticolonialismo expresso do cosmopolitismo político defendido pelo doutrinador alemão do direito racional.Abstract: Kant distinguishes between State’s right, peoples´ right and cosmopolitan right. This article exposes the moral principle of Kantian cosmopolitanism and the underlying proposal of political cosmopolitanism. The paper highlights Kant´s cosmopolitan position against the background of internationalism that proposes a planetary vision of civil society (J. Habermas) and the jusnaturalism that defends the figure of a citizen of the world along with that of national citizenship (O. Höffe). The text intends to do justice to the open anticolonialism of the political cosmopolitanism that is defended by the German doctrinaire of rational right.
SER INICIADO AO AMOR AS RELAÇÕES ENTRE CULTOS DE MISTÉRIO E PAIDÉIA A PARTIR DO BANQUETE DE PLATÃO
Authors: Loredo Carlos Roberto 
Published: July 2016

O texto do Banquete de Platão faz várias referências, diretas e indiretas, a cultos gregos de Mistério do período clássico, a saber, os Mistérios de Elêusis, Dionisíacos e Órficos. O objetivo deste artigo é, partindo destas referências, mostrar as relações existentes entre os cultos de Mistério e a paidéia de Platão e analisar o significado destas relações. Para tanto, apresentaremos uma caracterização da religiosidade mistérica em geral e aspectos específicas dos três Mistérios supra citados; depois apresentaremos a visão platônica de eros no Banquete e a proposta de paidéia que está subjacente a ela para, então, caracterizar as três relações que podemos inferir que há entre paidéia platônica e Mistérios, a partir da análise do Banquete, ou seja, as relações de homologia teleológica, homologia estrutural e distinção metodológica. Por fim, abordaremos o significado destas relações.Abstract: Plato’s Banquet, makes, directly or indirectly, several references to the Greek Mystery cults of the Classical period, that is, the Eleusians, Dionysiac and Orphic Mysteries. Using the above references as a starting point, this paper aims at showing the existing relationships between the Mystery cults and Plato’s paideia, and analyzing the significance of such relationships. We will therefore present a general characterization of mysteric religiosity as well as some specific aspects of the three Mysteries mentioned above. Then, we will introduce the Platonic vision of Eros in the Banquet and the proposal of a paideia that underlies such a vision. This analysis of the Banquet will help characterize the three relationships that can be inferred between Platonic paideia and the Mysteries, that is to say, the relationships of teleological homology, structural homology and methodological distinction. Finally, we will approach the significance of theses relationships.
A INTERPRETAÇÃO ANALÓGICA DAS RELAÇÕES ENTRE NIILISMO GNÓSTICO E NIILISMO EXISTENCIALISTA SEGUNDO HANS JONAS
Authors: De Oliveira Jelson R. 
Published: July 2016

Pretende-se examinar as principais teses da análise hermenêutica realizada por Hans Jonas sobre o movimento gnóstico antigo, bem como estudar as principais formulações analógicas que lhe permitem afirmar que o dualismo está na base da formulação das ideais gnósticas, e que ele serviria de fio condutor para a apreciação das ideias existencialistas, de forma a fazer transparecer a similitude de ambas as correntes filosóficas. Para isso, serão analisados os pressupostos teóricos, filosóficos e históricos levantados por Jonas a respeito do gnosticismo e, posteriormente, alinhadas as principais convergências dos dois “sistemas” de descrição da situação do homem no mundo.Abstract: The aim of this article is to analyze the main thesis of the hermeneutic analysis performed by Hans Jonas about the ancient Gnostic movement. It also examines the major analog formulations that allow him to say that dualismo underlies the formulation of Gnostic ideas, and that it could serve as a guide for the assessment of existentialist ideas, in order to highlight the similarity of both philosophies. For this, we will analyze the theoretical, philosophical and historical assumptions raised by Jonas about Gnosticism and finally, we will discuss the main convergences of the two “systems” to describe the situation of man in the world.
J.-J. ROUSSEAU E O DRAMA DA HISTÓRIA HUMANA
Authors: Oliveira Richard Romeiro Oliveira 
Published: July 2016

Resumo: A reflexão política e moral levada a cabo por Rousseau constitui, de certo modo, uma das principais matrizes teóricas da perspectiva historicista que, a partir de um determinado momento, se tornou hegemônica no contexto do pensamento moderno. Com efeito, por meio de sua reflexão, Rousseau instaura e desenvolve uma nova concepção antropológica que nos apresenta o homem não mais como um ser dotado de uma natureza imutável e desde sempre determinada, mas como o produto de um devir ou de um processo responsável pela irrupção de transformações radicais em sua constituição profunda. No entanto, apesar de conceber o processo histórico como um elemento fundamental na configuração da realidade propriamente humana, Rousseau não compartilhou da crença iluminista no progresso, visualizando a história do homem não como uma marcha irresistível em direção ao melhor, mas, antes, como um fenômeno fundamentalmente ambíguo, envolvendo um descompasso entre desenvolvimento intelectual e desenvolvimento moral. O objetivo do presente artigo é explorar e analisar essa concepção do caráter fundamentalmente ambivalente do processo histórico em Rousseau, buscando compreender suas principais articulações teóricas e conceituais. Abstract: The political and moral reflection accomplished by Rousseau constitutes somehow one of the principal theoretical sources of historicist perspective that became hegemonic in a given moment in the context of modern thought. In fact, through his reflection Rousseau establishes and develops a new anthropological conception that does not portray man as a being having an immutable and ever- -determined nature, but as the product of a becoming or process responsible for the emergence of radical changes in his inner constitution. However, in spite of conceiving the historical process as a fundamental element in the shaping of the proper human reality, Rousseau did not share the Enlightenment Faith in progress. For him, man’s history is not an irresistible move towards what is best, but it is rather an essentially ambiguous phenomenon, that involves an imbalance between intellectual development and moral development. The purpose of this paper is to explore and analyse Roussea`s conception of the ambivalent character of the historical process, trying to understand its main theoretical and conceptual articulations.
Can Care and Compassion—Be the Ultimate Solution of Terrorism?
Authors: Ray Urmi 
Published: July 2016

<p><em>Like a number of serious problems in our world terrorism is also one of them. Now what do we mean by; ‘terrorism’? It is a political phenomenon, where violence and bloodshed are brought upon the innocent citizens in order to shaken up the Government as it exploits the so-called terrorists. This is a set up which runs parallel with the main stream to devastate the main stream, in a secretive or clandestine method. Thus any violent bloodshed such as killing in robbery or insurgency cannot be called terrorism as there either the cause is not political as in case of killing in robbery; or common men are not targeted as in case of insurgency (although its cause is political). Again Guerilla tactic although is a clandestine or secretive method still it is not terrorism as here the units of the Government, that is innocent citizens are not killed. Revolution also involves violence but unlike terrorism it gains public support. The terrorists claim that they are actually waging a war against the Government, but in a war certain just rules are followed which states that proportionality between the means and end should be maintained, there should be a legitimate authority waging a war, it goes on within a particular territory, it should have a consistent success rate and most importantly it protects the immunity of the innocent mass. But in terrorism such rules of just war are lacking. Thus terrorism is a political violence between the mighty and the weak, for which it can also be called a class struggle or power struggle, where the weak sect shake the mighty by attacking upon those who are part and parcel of the mighty. This ‘ism’ is thus different from war, insurgency, revolution, crime and guerilla tactic because of its distinct feature that it does not attack its direct victim but attacks its indirect victim. In other words instead of destroying the Government which is guilty to them it attacks the innocent citizens of the Government because they are the units of the Government. Thus if the part is destroyed then the whole would automatically be shaken up. This unique mentality is found only in this ‘ism’ thus it differs from all other instances of violence. Terrorism is of two types—Terrorism from Above and Terrorism from Below. The former is also known as ‘State Sponsored Terrorism’ where the state is found to torture its citizens. The latter is termed ‘Non-State Terrorism’ where the exploited lot terrorizes the state for having been oppressed by it for years. The Non-State Terrorism is formed by the private parties such as Al Qaeda, Aum Shinrikyo, Maoists of India and so on.</em></p>
Digital Inclusion: A Tool for Empowerment
Authors: Kalla Neelam 
Published: July 2016

<div><p><em>In the contemporary picture there is conjoint consensus amongst all the policy makers from across the sphere that devoid of ICT and digital inclusion; the growth of an individual is stalled. Specially in developing economy like India, where poverty eradication and employment generation are foremost objectives; digital inclusion is a must. Considering factors like lack of infrastructure, primary education and availability affordable technologies and others, the strategic intervention and collaborative efforts by government and non-government organizations is indispensable. </em></p><p><em>Present study provides an analysis of secondary data in order to investigate the current status of digital inclusion and digital divide of Indian population. Further it also illustrates the strategies to eradicate the digital divide and cites example from successful digital inclusion campaigns from other parts of world. </em></p></div>
In Situ Stress Magnitude and Orientation in an Onshore Field, Eastern Niger Delta: Implications for Directional Drilling
Authors: Abija Abija , Ankwo Fidelis , Tse Tse 
Published: July 2016

Abstract
In situ stress magnitude and orientation are necessary for oil and gas field development planning to achieve optimal well placement whether vertical, deviated or horizontal, wellbore stability analysis for safe and stable drilling to reduce non-productive time, fault stability and cap rock integrity modeling for CO2 geosequestration and stage placement of hydraulic fracture for optimum production in unconventional plays. These were evaluated using wireline logs, leak off test and vertical seismic profile data in an onshore field, Eastern Niger Delta whose stratigraphic sequence is the typical interlayered, normal to abnormal pressured shales and sandstones of the Agbada Formation. The vertical stress magnitude ranges from 23.08 - 25.57 MPa/km, minimum effective horizontal stress from 13.80 - 14.03 MPa/km and maximum effective horizontal stress from 16.06 - 17.65 MPa/km inferring a normal fault stress regime. The minimum horizontal stress orientation varies from 16° - 33° forming the most stable orientation for geosteering a directional well while the maximum horizontal stress orientation is N60°E - N123°E in agreement with the regional fault orientations in the Niger Delta. ENE – WSW, WNW – ESE and other maximum horizontal stress orientations suggest multiple sources of stress, and in situ stress rotation across fault surfaces depicts wellbore instability issues. Structural evolution depicts NE – SW and NW-SE trending faults in the direction of the maximum horizontal stress. Directional well inclination angles of 16° and 33° were predicted in wells 10 and 11 respectively and mud weight window predicted using 2D Mohr - Coulomb failure criterion yielded an optimum mud weight window of 10 - 14.0ppg with overpressure accounting for mud weights as high as 25ppg and minimum mud weight exceeding the maximum mud weight in some sections.