bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial—FIRSTANA
Authors: Oudard Stéphane , Fizazi Karim , Sengeløv Lisa , Daugaard Gedske , Saad Fred , Hansen Steinbjørn , Hjälm-Eriksson Marie , Jassem Jacek , Thiery-Vuillemin Antoine , Caffo Orazio , Castellano Daniel , Mainwaring Paul N. , Bernard John , Shen Liji , Chadjaa Mustapha , Sartor Oliver 
Published: July 2017

Purpose In patients with metastatic castration-resistant prostate cancer (mCRPC), overall survival (OS) is significantly improved with cabazitaxel versus mitoxantrone after prior docetaxel treatment. FIRSTANA ( ClinicalTrials.gov identifier: NCT01308567) assessed whether cabazitaxel 20 mg/m2 (C20) or 25 mg/m2 (C25) is superior to docetaxel 75 mg/m2 (D75) in terms of OS in patients with chemotherapy-naïve mCRPC. Patients and Methods Patients with mCRPC and Eastern Cooperative Oncology Group performance status of 0 to 2 were randomly assigned 1:1:1 to receive C20, C25, or D75 intravenously every 3 weeks plus daily prednisone. The primary end point was OS. Secondary end points included safety; progression-free survival (PFS); tumor, prostate-specific antigen, and pain response; pharmacokinetics; and health-related quality of life. Results Between May 2011 and April 2013, 1,168 patients were randomly assigned. Baseline characteristics were similar across cohorts. Median OS was 24.5 months with C20, 25.2 months with C25, and 24.3 months with D75. Hazard ratio for C20 versus D75 was 1.01 (95% CI, 0.85 to 1.20; P = .997), and hazard ratio for C25 versus D75 was 0.97 (95% CI, 0.82 to 1.16; P = .757). Median PFS was 4.4 months with C20, 5.1 months with C25, and 5.3 months with D75, with no significant differences between treatment arms. Radiographic tumor responses were numerically higher for C25 (41.6%) versus D75 (30.9%; nominal P = .037, without multiplicity test adjustment). Rates of grade 3 or 4 treatment-emergent adverse events were 41.2%, 60.1%, and 46.0% for C20, C25, and D75, respectively. Febrile neutropenia, diarrhea, and hematuria were more frequent with C25; peripheral neuropathy, peripheral edema, alopecia, and nail disorders were more frequent with D75. Conclusion C20 and C25 did not demonstrate superiority for OS versus D75 in patients with chemotherapy-naïve mCRPC. Tumor response was numerically higher with C25 versus D75; pain PFS was numerically improved with D75 versus C25. Cabazitaxel and docetaxel demonstrated different toxicity profiles, with overall less toxicity with C20.
Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies at a University Medical Center
Authors: Josephs Sean A. , Lemmink Gretchen A. , Strong Judith A. , Barry Cassandra L. , Hurford William E. 
Published: July 2017

BACKGROUND:
Intraoperative lung-protective ventilation (ILPV) is defined as tidal volumes <8 mL/kg ideal bodyweight and is increasingly a standard of care for major abdominal surgical procedures performed under general anesthesia. In this study, we report the result of a quality improvement initiative targeted at improving adherence to ILPV guidelines in a large academic teaching hospital.

METHODS:
We performed a time-series study to determine whether anesthesia provider adherence to ILPV was affected by certain improvement interventions and patient ideal body weight (IBW). Tidal volume data were collected at 3 different time points for 191 abdominal surgical cases from June 2014 through April 2015. Improvement interventions during that period included education at departmental grand rounds, creation of a departmental ILPV policy, feedback of tidal volume and failure rate data at grand rounds sessions, and reducing default ventilator settings for tidal volume. Mean tidal volume per kilogram of ideal body weight (VT/kg IBW) and rates of noncompliance with ILPV were analyzed before and after the interventions. A survey was administered to assess provider attitudes after implementation of improvement interventions. Responses before and after interventions and between physician and nonphysician providers were analyzed.

RESULTS:
Reductions in mean VT/kg IBW and rates of failure for providers to use ILPV occurred after improvement interventions. Patients with IBW <65 kg received higher VT/kg IBW and had higher rates of failure to use ILPV than patients with IBW >65 kg. Surveyed providers demonstrated stronger agreement to having knowledge and practice consistent with ILPV after interventions.

CONCLUSIONS:
Our interventions improved anesthesia provider adherence to low tidal volume ILPV. IBW was found to be an important factor related to provider adherence to ILPV. Provider attitudes about their knowledge and practice consistent with ILPV also changed with our interventions.
The cell polarity proteins Boi1p and Boi2p stimulate vesicle fusion at the plasma membrane of yeast cells
Authors: Kustermann Jochen , Wu Yehui , Rieger Lucia , Dedden Dirk , Phan Tamara , Walther Paul , Dünkler Alexander , Johnsson Nils 
Published: July 2017

ABSTRACT
Eukaryotic cells can direct secretion to defined regions of their plasma membrane. These regions are distinguished by an elaborate architecture of proteins and lipids that are specialized to capture and fuse post-Golgi vesicles. Here, we show that the proteins Boi1p and Boi2p are important elements of this area of active exocytosis at the tip of growing yeast cells. Cells lacking Boi1p and Boi2p accumulate secretory vesicles in their buds. The essential PH domains of Boi1p and Boi2p interact with Sec1p, a protein required for SNARE complex formation and vesicle fusion. Sec1p loses its tip localization in cells depleted of Boi1p and Boi2p but overexpression of Sec1p can partially compensate for their loss. The capacity to simultaneously bind phospholipids, Sec1p, multiple subunits of the exocyst, Cdc42p and the module for generating active Cdc42p identify Boi1p and Boi2p as essential mediators between exocytosis and polar growth.
RARE ELEMENTS (ZR, NB, LA, CE AND HF) IN TRAFFIC EMITTED FERRIMAGNETIC PARTICLES FROM ROAD DUSTS
Authors: Bourliva A. , Papadopoulou L. , Aidona E. 
Published: July 2017

In the present study, the presence and the elemental contents of some rare elements such as zirconium (Zr), niobium (Nb), lanthanum (La), cerium (Ce) and hafnium (Hf) in different fractions (bulk samples, non-magnetic fraction NMF and magnetic fractionMF) of road dusts from the city of Thessaloniki, were nvestigated. The mean Zr, Nb, La, Ce and Nb concentrations in the bulk road dust samples were 32.1, 5, 16.4, 40 and 0.9 μg g-1 ,αντίστοιχα.. On the other hand, the studied rare elements concentrations in magnetic fractions (MFs) were enriched and the enrichment ratios, defined as the concentration ratio of metals in MFs and NMFs, ranged between 1.9 (Ce) and 7.9 (Nb). Pearson’s correlation coefficients in the MFs indicated 3 groups of elements originating from common source: a) Zr-Hf-Cr-Cu-Mo-Sn-Sb, b) Nb-Ni-Cu-Mo-Sn and c) La-Ce. The significant correlations of the Zr, Hf and Nb with elements such as Cu, Sb, Sn and Mo which are characteristic of brake wear emissions indicated that the emission of these elements in the urban environment can also be attributed to vehicular traffic as they are highly associated with traffic emitted ferrimagnetic particles.
Constructing gendered identities: the rhetorics of gender in the NGO’s volunteers’ talk about sex trafficking
Authors: Μάκη (Kostoula Maki) Κωστούλα 
Published: July 2017

This study examines the construction of gendered identities in Greek NGO volunteers’ discourse about sex trafficking, from the perspective of critical discursive social psychology and recent feminist post-structuralist theory. More specifically, the key analytical tools of the study’s methodology are the concepts of interpretative repertoires and ideological dilemmas (Potter and Wetherell, 1987, Wetherell, 1998, Billig, Condor, Edwards, Gene, Middleton, and Radley, 1988). The analysis highlights the link between the social construction of gender and sex trafficking. Gender is an object of negotiation in the volunteers’ discourse on sex trafficking and is related to specific ideological positions and dilemmas that emerge from the analysis.
The study consists of 32 semi structured interviews with volunteers working for NGOs in Greece. The NGOs were classified in four categories according to their profile. Those categories are:

NGOs with a humanistic profile.
NGOs with a religious profile.
NGO’s with a medical profile.
NGO’s with a feminist profile.

The survey’s data were collected between the months of June and December 2009. The interviews were conducted in the cities of Athens, Thessaloniki and Ioannina. Each interview lasted between one hour and one hour and a half. At this initial stage interviews were transcribed for content only. The data corpus adds up to approximately 800 A4 typewritten pages.
The analysis of this study is presented in chapter 7, 8 and 9. Chapter 7 examines sex trafficking as a criminal activity. Chapter 8 examines the “moral panic” that surrounds sex trafficking discourses. The final chapter (9), deals with the connection of sex trafficking to the “underdeveloped countries” and the ideological dilemmas that are related to it.
Disability Policy Evaluation: Combining Logic Models and Systems Thinking
Authors: Claes Claudia , Ferket Neelke , Vandevelde Stijn , Verlet Dries , De Maeyer Jessica 
Published: July 2017

Abstract
Policy evaluation focuses on the assessment of policy-related personal, family, and societal changes or benefits that follow as a result of the interventions, services, and supports provided to those persons to whom the policy is directed. This article describes a systematic approach to policy evaluation based on an evaluation framework and an evaluation process that combine the use of logic models and systems thinking. The article also includes an example of how the framework and process have recently been used in policy development and evaluation in Flanders (Belgium), as well as four policy evaluation guidelines based on relevant published literature.
Audience behaviours and digital television policy measures in Italy: A qualitative investigation
Authors: Papa Filomena , Sapio Bartolomeo , Nicolò Enrico 
Published: July 2017

Abstract
A transition process to new Digital Terrestrial Television (DTT) technologies is in progress in Europe, connected to the release of the 700 MHz band. In the management of this new technological transition, the experience gained in the previous transition process (from analogue to digital) could provide useful insight to help reduce costs and promote citizens’ uptake of new technologies. This article presents an investigation into the use behaviour of adults not using the Internet during the DTT transition and their future expectations regarding TV services. As a broad reference, we adopted both user experience and user acceptance models, in particular the Unified Theory of Acceptance and Use of Technology (UTAUT). Following a qualitative methodological approach, three focus groups were carried out, involving adult non-Internet users. The results confirm that user segmentation is critical not only on the basis of socio-demographic variables but also according to the definition of appropriate cultural models. A segmentation into four micro-cultures (‘Ideologically against’, ‘Inadequates’, ‘Enthusiasts’, ‘Indigents’) emerges. This segmentation can inspire different tactical interventions to encourage the adoption of digital media and different policy measures, such as communication campaigns, specific support modalities and economic incentives. In order to face the 700 MHz band transition process, it is advisable to carry out ad hoc qualitative surveys with the direct involvement of citizens, in order to identify the most appropriate measures to be implemented in favour of the corresponding user segments.
Rocking against patriarchy: Single-sex solutions for female musicians
Authors: Gregory Georgina 
Published: July 2017

Abstract
Opinions on the merits of single sex education are divided, but it is acknowledged that this context for learning offers certain benefits for female musicians. This is particularly true for female rock guitarists and drummers, who are under-represented and rarely achieve virtuoso status. The scarcity of women musicians in rock and heavy metal is noted by various feminist scholars, but solutions to the problem of under-representation are elusive. In order to perform rock music professionally, women must develop initial musicianship skills. However, many girls and younger women report being intimidated, marginalized or excluded in rock bands, making it harder for them to gain experience. This article draws attention to two recent developments – female rock tributes and rock camps for women and girls – presenting them as offering a feminist solution for women who would like to perform metal and rock music with confidence.
Rethinking the Guidonian hand for twenty-first-century musicians
Authors: Fleet Paul 
Published: July 2017

Abstract
The immediate recognition and description of the thirteen enharmonic intervals within an octave is a quest upon which students on popular music degree programmes frequently embark, but which they rarely complete. The problem often lies in a disconnect between the sound heard and the sound recognized when the task is undertaken without recourse to an instrument. During the eleventh century, Guido d’Arezzo used the joints on the hand (phalanges) to help music students recognize and sing intervals from hexachords. This article considers rethinking this tool with regard to recent investigations into corporeal intentionality. The approach is developed across three short incremental exercises that are designed for the twenty-first-century musician. It begins by connecting the familiar singing of a major scale whilst pointing to the phalanges of the hand, moving towards inflecting the scale by singing and pointing to non-sequential intervals.
Giving it all away: Race, locale and the transformations of blues harmonica education in the digital age
Authors: Gussow Adam 
Published: July 2017

Abstract
This essay explores the transformation of blues harmonica education in recent decades, via changes in the racial cohorts of teachers and students, emergence of digital technologies and dematerialization of teaching contexts. As a by-product of the ‘whitening’ of the American blues scene between 1960 and 1970, ‘old-school’ pedagogical exchanges constituted by black masters and apprentices modulated to include white apprentices. Tony ‘Little Sun’ Glover’s instructional Blues Harp (1965) marks a key transition: an erstwhile white master engaging in distance learning with an invisible cohort of students. Subsequently, literature scholar and blues harp player/teacher, Gussow, vowed to ‘give it all away on YouTube’, creating a pioneering website for peddling instructional videos. He also interrogates racial problematics of his business model, sketches his blues apprenticeships with older African Americans and concludes with a story about his own younger black apprentice, a Memphis teen who wins a ‘Star Search’ competition, harmonica in hand.
Book Reviews
Authors: Beauregard Julie , Gulish Sarah 
Published: July 2017

Abstract

Remixing the Classroom: Toward an Open Philosophy of Music Education, Randall Everett Allsup (2016)
Bloomington, Indiana: Indiana University Press, 198 pp.,
ISBN: 978-0253021427, $27.00

When Music Goes to School: Perspectives on Learning and Teaching, D. Littleton (2015)
Lanham, MD: Rowman & Littlefield Publishing Group, Inc., 172 pp.,
ISBN-13: 978-1475813357, paperback: $30.00, hardback: $60.00
THE INTERACTION OF HUMAN OSTEOBLAST-LIKE Saos-2 CELLS WITH STAINLESS STEEL AND Si(100) COATED BY SILICALITE 1 FILMS
Authors: Jirka Ivan , Vandrovcová Marta , Plšek Jan , Bačáková Lucie 
Published: July 2017

<p>Interaction of osteoblast-like <em>Saos-2</em> cells with stainless steel and Si(100) covered by a film of densely intergrown silicalite-1 crystals is investigated. Surface properties of the films are tuned by synthesis conditions and post-synthetic modifications. A number of adhered cells is affected by surface morphology and wettability of the film.</p>
Transitivities of maps on G-spaces
Authors: Garg Mukta , Das Ruchi 
Published: July 2017

AbstractIn this paper, we define various kinds of transitivity of maps onG-spaces. We obtain conditions onG-spaces and on maps for one type of transitivity to imply another type of transitivity. Giving several examples and proving various equivalences, we provide a complete description of the relationships among the different types of transitivities defined for maps onG-spaces.
E-Book-Metadaten Pool und E-Book-Management Tool – ein Kooperationsprojekt von BSZ und VZG
Authors: Block Barbara , Kühn Roswitha 
Published: July 2017

Zusammenfassung
Im Rahmen der Kooperation des Gemeinsamen Bibliotheksverbundes (GBV) und des Bibliotheksservicezentrums Baden-Württemberg (BSZ) wurde als gemeinsames Projekt ein E-Book-Metadaten Pool aufgebaut. Ziel ist es, möglichst schnell und flexibel mit den Metadateneinspielungen in die Verbundsysteme und damit in die lokalen Kataloge zu reagieren, wenn neue Lizenzierungen aus den Teilnehmerbibliotheken gemeldet werden.
Zusätzlich wurde im BSZ ein E-Book-Metadaten-Management Tool (das EBM-Tool) programmiert, über das die Informationen zu Lizenzen und Paketen im E-Book-Pool verwaltet werden können.
Einführung des Qualitätsmanagementmodells „Ausgezeichnete Bibliothek“ an der Hochschulbibliothek Heilbronn
Authors: Zoller Rahel , Dolch Dagmar 
Published: July 2017

Zusammenfassung
Die Bibliothek der Hochschule Heilbronn erhält im Mai 2017 als eine der ersten Hochschulbibliotheken für Angewandte Wissenschaften das Zertifikat „Ausgezeichnete Bibliothek“. Dieser Projektbericht beschreibt die Arbeit der vorausgehenden drei Jahre, die Besonderheiten und das Vorgehen vor Ort sowie die dadurch entstandenen Verbesserungen und Ergebnisse.
Role of TRAF3 in neurological and cardiovascular diseases: an overview of recent studies
Authors: Cullell Natalia , Muiño Elena , Carrera Caty , Torres Nuria , Krupinski Jerzy , Fernandez-Cadenas Israel 
Published: July 2017

AbstractTumour necrosis factor receptor-associated factor 3 (TRAF3) is a member of the TRAF adaptor protein family, which exerts different effects on the cell depending on the receptor to which it binds and the cell type in which it is expressed. TRAF3 is a major regulator of the innate immune response. To perform its functions properly,TRAF3is transcriptionally and epigenetically regulated. At the transcriptional level,TRAF3expression has been associated with neurological and cardiovascular diseases including stroke, among other pathologies. Epigenetic modifications ofTRAF3have been observed at the histone and DNA levels. It has been observed that acetylation ofTRAF3, as well as other NF-κβ target genes, is associated with cardiac hypertrophy. Furthermore,TRAF3methylation has been associated with vascular recurrence after ischemic stroke in patients treated with clopidogrel. In this overview, we summarise the most interesting studies related to transcriptional and epigenetic regulation ofTRAF3focusing on those studies performed in neurological and cardiovascular diseases.
Critical Modeling & Exergy Analysis of Multi Phase Change Materials Storage System
Authors: Hosseininasab Seyedalireza , Nemati Lay Ebrahim 
Published: July 2017

AbstractUsing the phase change materials (PCMs) can help to store thermal energy as latent heat method in the multi PCMs storage system. In this research study, an analytical model has been developed for solar thermal storage system. An especial shell and tube heat exchanger is considered to heat exchange purpose. Double pipes have been used as tubes and PCMs allocated on the shell side of the double pipes for the heat exchanger. The hot heat transfer fluid (HTF) flows across the tube banks to charge the thermal energy storage system during the charging cycle. The thermal energy absorbed in PCMs while the HFT temperature reduced in the charging process. The heat exchanger tube length is function of HTF residence time then the equivalent length is defined in the presented model. The validity of the proposed model has been checked by comparison between the analytical results and numerical data obtained before using CFD simulation. The result shows that required times to melt of the PCMs for the presented study has the consistency of about 0.928 with CFD results in different PCMs melting percentages. Also the required time to melt of the PCMs for the presented study has the consistency of 0.915 with CFD results in different air inlet temperatures. Therefore the presented model can predict the system behavior also can apply for cascaded PCMs storage systems for exergy analysis.
Challenges in preparation of metal-containing nanocomposites; dispersion of titanium into plastics
Authors: Sur Gunjan , Chhabra Pranshu , Gupta Ruchi , Saxena Shikha , Tyagi Mukti , Seshadri Geetha , Verma Gurucharan Lal , Khandal Rakesh Kumar 
Published: July 2017

AbstractMetal containing polymers are of great interest as they have proven to be the most promising materials for applications such as microelectronics, holography and magnetic recording of information. Metal containing polymers also provide an alternative to even the specialty glass materials conventionally used for optical applications. Metals such as barium, lead and lanthanum have been used to improve the optical properties such as refractive index and mechanical properties such as hardness of optical plastics. The metal-containing optical plastic materials with improved refractive index of as much as 1.60 along with the Abbe number of more than 30 have been successfully designed using these metals by the authors of this paper. To further increase the refractive index without any drop in Abbe number and to improve the hardness of the polymer matrix, titanium would be the most promising metal. Incorporation of titanium in plastic matrices to form homogeneous and optically clear compositions is a challenging task. This paper reviews the state-ofthe- art by which titanium can be dispersed in polymer matrices to form metal containing composites as optical plastics.
Novel silane based cross-linkers for preparation of methyl methacrylate gels
Authors: Naghash Hamid Javaherian , Garshasb Mir 
Published: July 2017

Abstract(2,2'-(Dimethylsilanediyl)bis(oxy)bis(ethane-1,2-diyl)bis(2-methylacrylate) (Type A cross-linker), (2,2'-(methyl) (phenyl) silanediyl)bis(oxy) bis (ethane-1,2- diyl)bis(2-methylacrylate)) (Type B cross-linker), and (2,2'-(diphenylsilanediyl)bis (oxy)bis(ethane-1,2-diyl)bis(2-methylacrylate)) (Type C cross-linker) three novel cross-linkers, (divinyl monomers), containing silanes and two methacrylates group (Si-DVM) were prepared by the condensation of 2-hydroxyethyl methacrylate (HEMA) with dichlorodimethyl, (DCDM) dichloromethyl phenyl (DCMP) and dichlorodiphenyl silane (DCDPS) in the presence of triethylamine (TEA). With these cross-linkers, methyl methacrylate, (MMA) can copolymerize by free-radical cross-linking copolymerization in toluene at a total monomer concentration of 3 molL-1 and at 70 °C. The experimental results show that increasing of Si-DVM concentration resulted in a decrease in gel point and swelling degree and an increase in conversion percent and weight fraction of the gels. The obtained crosslinkers were characterized by 1H-NMR and 13C-NMR spectroscopy and structural characteristics of the gels were examined by using equilibrium swelling in toluene solvent, gel fraction and Fourier-transform infrared (FTIR) analysis. The morphology of the copolymers was also investigated by Scanning electron microscopy (SEM).