bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory‐based classification of rums: a chemometric and machine learning analysis
Authors: Rincón‐López Juliana , Chica Juanita Castro , Rojas Victoria Eugenia Recalde , Martínez Liliana Moncayo , Gartner Ángela María Arango , Rosero‐Moreano Milton , Taborda‐Ocampo Gonzalo 
Published: September 2024

SummaryThe Industria Licorera de Caldas (ILC) stands as a major liquor factory in Colombia, specialising in the production of various rum types including Tradicional, Juan de la Cruz, Carta de Oro, and Reserva Especial. These rums, as congeneric drinks, are known for their rich content of volatile compounds that define their sensory characteristics. To be commercialised, each rum batch must comply with Colombian standard NTC278 which defines rigorous assessment of congener content and various physicochemical parameters. Thus, the ILC has accumulated a vast amount of data over the years. This study conducts a comprehensive analysis of ILC rums, using chemometric techniques and machine‐learning classification models such as PCA, KNN, LDA, and RF. The aim was to distinguish between rum types based on parameters specified for standard compliance, streamlining the process without the need for additional or extensive new methodologies. As a result, through PCA data exploration, it was revealed that acetaldehyde, ethyl acetate, and isobutanol levels are instrumental in differentiating rum variants. Similarly, all classification models achieved accuracy levels exceeding 0.83 and precision surpassing 0.93. These findings pave the way for further research in the development of an ILC‐specific sensor for rapid and reliable liquor authenticity testing.
Effect of larval instar and post‐harvest treatments on heavy metals in BSFL and frass reared on commercial food waste streams
Authors: Alagappan Shanmugam , Mallard Sam , Cozzolino Daniel , Mikkelsen Deirdre , James Peter , Mantilla Sandra Olarte , Yarger Olympia , Hoffman Louwrens 
Published: September 2024

SummaryThe use of black soldier fly larvae (BSFL) to valorise different organic waste streams and the subsequent use of resulting larvae as a feedstock ingredient is increasing rapidly in several regions across the globe. The lack of knowledge about several safety issues including chemical contaminants (e.g. heavy metals) seems to affect the upscaling and commercialisation of this product. This study evaluates the safety of the BSFL against chemical contaminants including heavy metals and mycotoxins in both BSFL and frass samples reared with different food waste streams (e.g. soy waste, customised bread‐vegetable diet, food waste mixture, supermarket and childcare centre) from two commercial production facilities. The effect of larval instars and post‐harvest treatments (e.g. blanching and drying) on the safety of the BSFL was also investigated. The concentration of heavy metals was primarily influenced by the concentration in the food waste streams. The concentration was also higher in 6th instar compared to 5th instar larvae. The effect of blanching and drying have a varied effect on the concentration of heavy metals. Mycotoxins were found to be below the limit of quantification for all samples. The outcomes of this study indicated that BSFL grown on food waste streams and the resulting frass is safe against different heavy metals analysed. The findings of this study will assist the commercial BSFL manufacturers with the identification of relevant control points to ensure the chemical safety of their products. Therefore, encourage the use of different food waste streams as feedstock for rearing BSFL.
Development and characterisation of gluten‐free fresh pasta using teff, rice, and buckwheat flours enhanced with thermal waters: a mixture design approach
Authors: da Silveira Tayse F. F. , Hasni Jihene , Portelada Nathalie , Fernandes Filipa A. , Rodrigues Paula , Lemos André , Ferreira Isabel C. F. R. , Alves Maria José , Barros Lillian , Heleno Sandrina A. 
Published: September 2024

SummaryTo meet the demand for gluten‐free (GF) products, this study developed artisanal fresh pasta using teff, rice, and buckwheat flours, enhanced with mineral‐rich thermal waters (TW). A mixture design approach optimised flour proportions to balance texture, cooking time, water absorption, and cooking loss, along with functional properties such as total phenolic compounds (TPC) and antioxidant activity. Two promising formulations were identified: 36.3 g buckwheat, 9.35 g rice, and 9.35 g teff; and 27.5 g teff and 27.5 g buckwheat. These formulations, with and without TW, were evaluated for chemical, technological, microbiological, and functional attributes. The pasta had satisfactory technological properties, macronutrient levels comparable to standard pasta, and was rich in phenolic compounds with antioxidant activity. Ca, Zn, Fe, K, and Mn were predominant, although TW incorporation did not significantly affect their levels in the samples. All formulations showed microbiological stability for at least 3 days at 4 °C.
Antioxidant and antiglycating properties of ethanolic extracts from different parts of Neltuma ruscifolia pods
Authors: Seling Giuliana Silvina , Rivero Roy Cristian , Busch Verónica María , Buera María del Pilar 
Published: September 2024

SummaryNeltuma ruscifolia, a neglected underutilised species (NUS) within the Fabaceae family, lacks formal commercial recognition, despite its nutritional richness and endemic status. The objective of this study was to evaluate the antioxidant and antiglycating properties, as well as to identify associated bioactive compounds, in extracts (ultrasound and agitation) of different grinding fractions of N. ruscifolia seeds. Bioactivity varied depending on the extraction procedure and milling fraction, with the highest value in ultrasound‐extracted residue (exocarp, mesocarp). Some additional polyphenolic compounds (like hydroxybenzoic/ellagic acids) only appeared upon ultrasound‐assisted extraction. It was possible to identify some polyphenols (such as chrysin, rutin, kaempferol and cinnamic, coumaric, protocatechuic, ellagic and caffeic acids) that were highly related to the bioactivity. The antioxidant, antiglycating, colourant and technological properties of the extracts different fractions of N. ruscifolia pods are mainly dependent on the selected milling fraction. The extraction method, in a second place, significantly affects the resulting quantity and the type of extracted compounds, defining their potential applications.
Development of chitosan nanoparticle loaded with Tricholoma fracticum extract and evaluation of in vitro antioxidant activity
Authors: Canbolat Fadime , Acar İsmail , Tezel Ruhiye Nilay 
Published: September 2024

SummaryThe objective of this study was to develop Tricholoma fracticum extract‐loaded chitosan nanoparticles (TFNPs) by ionic gelation method and to evaluate their in vitro antioxidant activity. Phenolic and flavonoid contents in the T. fracticum extract were measured spectrophotometrically and chromatographically. Characterisation of NPs was evaluated by field emission scanning electron microscopy (FE‐SEM), transmission electron microscopy (TEM), ZETA analysis, Fourier‐transform infrared spectroscopy (FT‐IR), UV–visible spectroscopy (UV–Vis) and thermogravimetric analysis (TGA). In vitro antioxidant capacity was determined using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) assays. The phenolic and flavonoid contents in the T. fracticum extract were measured as 7.1 ± 0.3 mg Gallic Acid Equivalent/g extract and 5.5 ± 0.6 mg Quercetin Equivalent/g extract, respectively. The particle size, polydispersity index (PDI) and zeta potential of Blank NP1 and TFNP were 265.5 ± 15.8 nm, 0.4, 38.7 ± 4.0 mV and 333.2 ± 16.3 nm, 0.4, 37.0 ± 4.1 mV, respectively. The highest antioxidant activity was observed in TFNP, followed by T. fracticum extract, chitosan and blank NP, respectively. The preserved or enhanced antioxidant activity observed in the encapsulated T. fracticum extract indicates the potential for loading similar mushroom extracts onto chitosan and thus preserving their bioactive properties.
Antithrombotic and ACE‐inhibitory activity of milk fermented by Lacticaseibacillus rhamnosusGG and Lactobacillus delbrueckii ssp. bulgaricus
Authors: Guzmán‐Rodríguez Francisco , Gómez‐Ruiz Lorena , Cruz‐Guerrero Alma 
Published: September 2024

SummaryIn this work, the antihypertensive and antithrombotic activities of milk fermented with Lacticaseibacillus rhamnosus GG and Lactobacillus delbrueckii ssp. Bulgaricus NCFB 2772 (monoculture and co‐culture), were studied. It was observed that both species, as well as the co‐culture, showed an increase in proteolytic activity during fermentation, which is related to the increase in the biological activities studied. Both biological activities increased as a function of fermentation time, describing a curve similar to that of their proteolytic activity, which could indicate the release of bioactive peptides due to the proteolytic activity of the bacteria. The highest antihypertensive activity was obtained at 12 h of fermentation and was 74.9% for Lb. rhamnosus, 79.1% for L. delbrueckii and 77.6% for the co‐culture, with no significant difference between these values. On the other hand, the antithrombotic activity was 56.1% for Lb. rhamnosus, 49.9% for L. delbrueckii and 72.3% for the co‐culture. These findings contribute to the knowledge about the influence of fermentation conditions on biological activity of fermented milk, while emphasising the additional benefits of probiotic and industrially important lactic acid bacteria.
Effect of ball‐milling treatment on the structural and functional characteristics of Litopenaeus vannamei protein
Authors: Liu Yangliu , Wang Dan , Guo Mingzhu , Sun Jilu , Wu Hao 
Published: September 2024

SummaryBall‐milling is increasingly recognised as an efficient and environmentally friendly physical modification method in food processing. In this study, natural Litopenaeus vannamei protein (LVP) was subjected to ball‐milling treatment for 0, 5, 10, 15 and 20 min, respectively. Then, its structure and functional properties were investigated. Results indicated that proper ball‐milling treatment significantly enhanced the quality of LVP by influencing its structure. Specifically, ball‐milled LVP (BLVP) powder exhibited finer and brighter. BLVP subjected to 10 min demonstrated the highest solubility (22.80%), digestibility (64.50%) and foaming stability (93.69%), which were attributed to particle size and structure. BLVP processed for 15 min exhibited the highest oil holding capacity (1042.67%) and foaming capacity (17.11%), positively related to its surface hydrophobicity and sulfhydryl content. And its allergenicity decreased by 4.35%. These results provide a foundational framework for utilising ball‐milling to modify LVP, suggesting that this method may enhance the industrial applications of LVP.
Effects of different oxidation methods on the functional properties and gel characteristics of hazelnut proteins
Authors: Jiang Hongyu , Hu Hao , Huang Ziyi , Liu Meichu , Lyu Chunmao 
Published: September 2024

SummaryThis study aimed to investigate the effects of different oxidation modes on the functional and gel properties of hazelnut proteins. The solubility of hazelnut protein showed a small trend when the oxidation level was low, and it decreased significantly with the increase in concentration. The maximum value of water‐holding capacity (WHC), emulsifying activity index (EAI), and emulsion stability index (ESI) was 343.33%, 56.00 m2 g−1, and 75.85 min at AAPH concentration of 1.0 mmol L−1, respectively. The functional properties of hazelnut proteins, except oil‐holding capacity (OHC), gradually reduced with the increase in malondialdehyde (MDA) concentration. H2O2 modified improved OHC, foaming capacity, foam stability, and EAI of hazelnut proteins, whereas WHC and ESI gradually decreased. The results of the secondary structure of hazelnut protein gels indicated a high ratio of α‐helix and β‐fold of the gels. Also, the increase in oxidation led to an increase in the gels' voids. Also, oxidation led to a rough and loose network structure of hazelnut protein gels. These results suggested that peroxyl radical, hydroxyl radical, and MDA produced during lipid peroxidation affected the interfacial properties of hazelnut protein and disrupted the formation of hazelnut protein gel, thus affecting the quality of hazelnut protein.
Nutritional enhancement, microstructural modifications, and sensory evaluation of mushroom‐enriched multigrain bread
Authors: Srivastava Anuradha , Attri Brij Lal , Kamal Shwet , Pathera Ashok Kumar , Kashyap Radhika , Verma Shailja , Sharma Ved Prakash 
Published: September 2024

SummaryMultigrain bread being nutritionally rich and convenient is one of the popular dietary options these days, particularly among urban dwellers. In this study, the effects of oyster mushroom powder (0–10%) supplementation on the nutritional, antioxidant, physical, textural, microstructural, and sensory attributes of multigrain bread were explored. Results showed a significant (P < 0.05) enhancement in the bread's nutritional profile, with increased levels of protein, fibre, vitamin D, iron, potassium, manganese, and zinc, along with improved antioxidant properties. Microstructural analysis revealed that mushroom powder caused rougher and more inhomogeneous starch granules in the crumb. Although the incorporation of mushroom powder led to denser, harder, and more fragile bread, as indicated by physical and textural changes, sensory evaluation indicated that up to 5% supplementation did not negatively impact consumer acceptability (P > 0.05). These findings suggest that oyster mushroom powder can be a beneficial functional ingredient in multigrain bread, enhancing its nutritional value while maintaining sensory quality.
A new digital droplet PCR method for looking at epigenetics in diffuse large B‐cell lymphomas: The role of BMI1, EZH2, and USP22 genes
Authors: Lusci Gemignani Alessio , Papotti Robel , Bomben Riccardo , Gattei Valter , Pozzi Samantha , Donati Valentina , Bettelli Stefania , Forti Elisa , Mansueto Giovanna , Di Napoli Arianna , Cox Maria Christina , Flenghi Leonardo , Rossi Pietro , Volpe Guido , Dardanis Dimitri , Bono Clara , Guerrini Francesca , Morganti Riccardo , Sacchi Stefano , Galimberti Sara 
Published: September 2024

AbstractIntroductionEpigenetics has been shown to be relevant in oncology: BMI1 overexpression has been reported in leukemias, EZH2 mutations have been found in follicular lymphoma, and USP22 seems to stabilize BMI1 protein. In this study, we measured the expression of BMI1, EZH2, and USP22 in lymph nodes from 56 diffuse large B‐cell lymphoma (DLBCL) patients.MethodsA new multiplex digital droplet PCR (ddPCR) has been set up to measure the expression of 4 genes (BMI1, EZH2, USP22, and GAPDH) in the same reaction on RNA extracted from paraffin‐embedded tissues.ResultsThe specificity of ddPCR was confirmed by a 100% alignment on the BLAST platform and its repeatability demonstrated by duplicates. A strict correlation between expression of BMI1 and EZH2 and BMI1 and USP22 has been found, and high expression of these genes was correlated with extra‐nodal lymphomas. Progression‐free survival (PFS) and overall survival (OS) were conditioned by IPI, bone marrow infiltration, and the complete response achievement. High levels of BMI1 and USP22 did not condition the response to therapy, but impaired the PFS, especially for patients defined at “high risk” based on the cell of origin (no germinal center [GCB]), high BCL2 expression, and IPI 3‐5. In this subgroup, the probability of relapse/progression was twice higher than that of patients carrying low BMI1 and USP22 levels.ConclusionHigh expression of BMI1 and of USP22 might be a poor prognostic factor in DLBCL, and might represent the target for novel inhibitors.
Retroperitoneal cutaneous ureterostomy following radical cystectomy: A multicenter comparative study of robotic versus open surgery
Authors: Sasaki Yutaro , Fukuta Kyotaro , Kadoriku Fumiya , Daizumoto Kei , Shiozaki Keito , Tomida Ryotaro , Kusuhara Yoshito , Fukawa Tomoya , Yanagihara Yutaka , Nakanishi Ryoichi , Yamaguchi Kunihisa , Yamamoto Yasuyo , Izaki Hirofumi , Takahashi Masayuki , Okamoto Kenjiro , Furukawa Junya 
Published: September 2024

IntroductionThe aim of this study was to evaluate the differences in perioperative outcomes of cutaneous ureterostomy (CUS) between open surgery (open radical cystectomy, ORC) and robot‐assisted surgery (robot‐assisted radical cystectomy, RARC), including the stent‐free rate, readmission rates due to urinary tract infection (UTI), and changes in renal function.MethodsBetween 2005 and 2023, a total of 37 patients underwent CUS following ORC, while 24 patients underwent CUS following RARC. Perioperative outcomes were compared between these two groups.ResultsThe patients in the RARC group were significantly older (p = 0.007) and had a significantly higher proportion of high‐risk cases with ASA‐PS ≥3 (p = 0.002). In addition, RARC was associated with a significantly lower estimated blood loss (p < 0.001) and a reduced transfusion rate (p = 0.003). Postoperative complication rates and the stent‐free rate were comparable between the ORC and RARC groups. Throughout a median follow‐up period of 2.6 years, rates of readmission due to UTI did not differ significantly between the two groups. Moreover, there were no differences in the change in estimated glomerular filtration rate before and after surgery and the 3‐year survival rates were similar across both groups.ConclusionsCUS following RARC appears to offer a safer alternative compared with CUS following ORC, and the stent‐free rates are comparable. The significantly lower estimated blood loss and transfusion rate associated with RARC are particularly favorable for elderly patients, those who are frail, and individuals with multiple comorbidities.
Experiences of Certified Peer Support Specialist Providing Formal Peer Support in Mental Health Services: A Systematic Review and Meta‐Synthesis
Authors: Ser Hui Xian Eileen , Pua Xin Yi Vera , Li Ziqiang , Goh Yong Shian 
Published: September 2024

ABSTRACTPeer support specialists (PSSs) in mental healthcare services are individuals recovering from mental health conditions and providing formal peer support to clients with similar conditions. Despite evidence of the benefits of this modality and the increasing demand for it, little is known about the PSSs' experiences in mental healthcare services. This review systematically synthesises available qualitative data on the certified PSSs' experiences in providing formal peer support in mental healthcare services. A search was performed across six electronic databases and one grey literature database for all published and unpublished qualitative studies in English between 2014 and 2022. Mixed‐methods studies were included if their qualitative data were extractable. This review included PSSs who provided formal peer support to clients with similar mental health conditions. The included studies were appraised through the Critical Appraisal Skills Program Qualitative checklist, while data extraction was done through a customised tool. Our meta‐synthesis revealed an overarching theme on certified PSSs' journey in mental healthcare services, alongside four main themes: (i) emotional impacts of being PSSs, (ii) struggle to justify their roles, (iii) complex roles of PSSs and (iv) sources of support. The review has provided an insightful understanding of the PSSs' roles and needs, for which there is a need to cultivate a supportive working environment. Given the difficulties in adopting the PSSs' roles, as demonstrated by our findings, future research should explore how mental healthcare organisations can address their work‐related challenges and cultivate a supportive working environment.
Effects of Psychoeducation on Caregivers of Individuals Experiencing Schizophrenia: A Systematic Review and Meta‐Analysis
Authors: Chow Jin Yin Alicia , Yeo Yu Ting Tracy , Goh Yong Shian 
Published: September 2024

ABSTRACTThe existing paradigm on recovery in mental health prioritises self‐empowerment and person‐centred, community‐based care, which necessitates family caregivers' collaboration to support individuals with schizophrenia in the community. However, the role of family caregivers is often under‐recognised and hence insufficiently supported. This consequently compromises caregivers' well‐being and, ultimately, the recovery of individuals with schizophrenia. Although caregiver‐targeted psychoeducation may offer practical support, its effectiveness lacks conclusive evidence. This review aimed to evaluate the impacts of psychoeducation on caregiver‐related outcomes (caregiver burden, quality of life and expressed emotion). Eight electronic databases were searched from inception to September 2023, supplemented by hand searching of end‐reference lists. Two reviewers independently conducted title and abstract screening with predetermined eligibility criteria. A third reviewer was consulted to resolve any discrepancies. A random‐effects meta‐analysis was performed to estimate pooled effect sizes alongside subgroup and sensitivity analyses where appropriate. Twenty‐one studies (totalling 1639 caregivers) were included, based on which psychoeducation contributed to a statistically significant improvement in caregiver‐related outcomes. Given substantial heterogeneity, subgroup and sensitivity analyses were done for the durations and the evaluative scales for psychoeducation. Quality appraisal revealed unclear or high bias in most studies. Notwithstanding the heterogeneity, the directions of the effect sizes consistently indicated the effectiveness of psychoeducation across all outcomes. This finding aligned with Lazarus' stress appraisal and coping theory, which states that psychoeducation improves caregivers' knowledge, coping mechanisms and situation appraisal. Our findings offer encouraging evidence to advocate the integration of psychoeducation into healthcare services, but policy‐based support is warranted for sustained implementation. Further research is merited to optimise its duration and content and appraise its long‐term impacts through disease‐specific scales for objective and subjective outcomes.
Resiliency in Persons Experiencing Homelessness: A Concept Analysis Using the Evolutionary Framework
Authors: Ketel Christian , Abdoli Samereh 
Published: September 2024

ABSTRACTIntroductionHomelessness is a critical societal issue, with those affected facing disproportionate chronic and acute health conditions. At the core of understanding their experiences is the concept of resiliency. Understanding resiliency in homelessness is crucial because it highlights the dynamic interplay between inherent qualities and external challenges, underscoring the need to reassess societal value judgements and inform nursing practices in research, education and advocacy.AimThis paper aims to conduct a comprehensive concept analysis to propose a revised definition of resiliency in the context of homelessness.MethodsRogers's evolutionary method was the analytical tool of choice, perfect for examining the fluid and evolving nature of resiliency within the context of homelessness. The method entails analysing the concept's transformation over time and across disciplines, accepting variability in definitions based on the chronological and contextual constructs.DiscussionThe findings revealed that resiliency in homelessness is an inherent quality and a developed response shaped by the interplay of innate capacities and environmental challenges. It uncovered a need to reassess societal value judgements. Resiliency among people without housing suggests strengths that go unrecognised by conventional measures.ConclusionThe analysis concludes that resiliency is not a static trait but a dynamic process encompassing individual, social and environmental dimensions. In each case, nursing is poised to make a significant difference in nursing research, practice, education and advocacy, potentially inspiring new approaches and interventions. No public or private was used in the development of this article.