bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines
Authors: Ghashm Abdulmlik A , Othman Nor H , Khattak Mohammed N , Ismail Noorliza M , Saini Rajan 
Published: July 2016

Abstract

Background
The treatment of oral squamous cell carcinomas (OSCC) and human osteosarcoma (HOS) includes surgery and/or radiotherapy which often lead to reduced quality of life. This study was aimed to study the antiproliferative activity of local honey (Tualang) on OSCC and HOS cell lines.

Methods
Several concentrations of Tualang honey (1% - 20%) were applied on OSCC and HOS cell lines for 3, 6, 12, 24, 48 and 72 hours. Morphological characteristics were observed under light and fluorescent microscope. Cell viability was assessed using MTT assay and the optical density for absorbance values in each experiment was measured at 570 nm by an ELISA reader. Detection of cellular apoptosis was done using the Annexin V-FITC Apoptosis Detection Kit.

Results
Morphological appearance showed apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation and fragmented nucleus on OSCC and HOS cell lines. Cell viability assay showed a time and dose-dependent inhibitory effect of honey on both cell lines. The 50% inhibitory concentration (IC
50
) for OSCC and HOS cell lines was found to be 4% and 3.5% respectively. The maximum inhibition of cell growth of ≥80% was obtained at 15% for both cell lines. Early apoptosis was evident by flow cytometry where percentage of early apoptotic cells increased in dose and time dependent manner.

Conclusion
Tualang honey showed antiproliferative effect on OSCC and HOS cell lines by inducing early apoptosis.
What evidence exists for the effectiveness of on-farm conservation land management strategies for preserving ecosystem services in developing countries? A systematic map
Authors: Thorn Jessica P. R. , Friedman Rachel , Benz David , Willis Kathy J. , Petrokofsky Gillian 
Published: July 2016

AbstractBackgroundAn extensive body of evidence in the field of agro-ecology claims to show the positive effects that maintenance of ecosystem services can have on meeting future food demand by making farms more sustainable, productive and resilient, which then contributes to improved nutrition and livelihoods of farmers. However, inconsistent effects have commonly been reported, while empirical evidence to support assumed improvements is largely lacking. Overall, a coherent synthesis and review of the evidence of these claims is largely absent from the literature.MethodsSystematic searches of peer-reviewed research were conducted in bibliographic databases of Web of Science, SCOPUS, AGRICOLA, AGRIS databases and CAB abstracts, and grey literature from Google Scholar, and 32 subject-specific websites. Searches identified 21,147 articles. After screening, 746 studies were included in the final map.ResultsOf the 19 conservation land management practices considered, soil fertilisation (24 %), tillage (23 %), agroforestry (9 %), and water conservation (7 %) were most commonly studied. Ecosystem services most commonly studied were supporting (55 %) and regulating (33 %), particularly carbon sequestration/storage, nutrient cycling and soil/water regulation/supply. Key data gaps identified included the absence of long-term records (with datasets spanning >20 years), studies located in North and Central Africa, research that focuses on smallholder landscapes, and studies that span different scales (regional and landscape levels).ConclusionsThe study employs systematic mapping combined with an online interactive platform that geographically maps results, which allows users to interrogate different aspects of the evidence through a defined database field structure. While studies are not directly comparable, the database of 746 studies brings together a previously fragmented and multidisciplinary literature base, and collectively provides evidence concerning a wide range of conservation land management practices impacting key ecosystem services. The systematic map is easily updatable, and may be extended for additional coding, analysed to assess the quality of studies, or used to inform future systematic reviews.
Vitamin D deficiency in critically ill patients with traumatic injuries
Authors: Dickerson Roland N. , Van Cleve Jonathan R. , Swanson Joseph M. , Maish George O. , Minard Gayle , Croce Martin A. , Brown Rex O. 
Published: July 2016

Abstract

Background
Vitamin D depletion has been associated with increased rate of infections, lengthened hospital stay, and worsened mortality for critically ill patients. The purpose of this study was to evaluate the prevalence and variables associated with vitamin D deficiency in critically ill patients with severe traumatic injuries.

Methods
Critically ill adult patients admitted to the trauma intensive care unit (ICU) between June 2013 and June 2014, referred to the nutrition support service for enteral or parenteral nutrition, and had a serum 25-hydroxyvitamin D (25-OH vitamin D) concentration determination were retrospectively evaluated. Patients were stratified as vitamin D sufficient, insufficient, deficient, or severely deficient based on a 25-OH vitamin D concentration of 30–80, 20–29.9, 13.1–19.9, and ≤13 ng/mL, respectively.

Results
One hundred and twenty-one patients out of 158 (76 %) patients were vitamin D deficient or severely deficient. Thirty-one patients (20 %) were insufficient and 6 (4 %) had a normal 25-OH vitamin D concentration. 25-OH vitamin D was determined 7.5 ± 5.1 days after ICU admission. African-Americans had a greater proportion of patients with deficiency or severe deficiency compared to other races (91 versus 64 %, P = 0.02). Penetrating gunshot or knife stab injury, African-American race, and obesity (elevated body mass index) were significantly associated with vitamin D deficiency or severe deficiency: OR 9.23 (1.13, 75.40), 4.0 (1.4, 11.58), and 1.12 (1.03, 1.23), P &lt; 0.05, respectively.

Conclusions
The majority of critically ill patients with traumatic injuries exhibit vitamin D deficiency or severe deficiency. Penetrating injuries, African-American race, and obesity are significant risk factors for deficiency. Severity of injury, extent of inflammation (elevated C-reactive protein concentration), or hospital admission during the winter season did not significantly influence the prevalence of vitamin D deficiency.
Cross-linked hyaluronic acid in pressure ulcer prevention
Authors: Beniamino P. , Vadalà M. , Laurino C. 
Published: July 2016

Objective: Long-term bedridden patients are at high risk of acquring pressure ulcers (PUs). In this group of patients, prevention is necessary to cut the health costs, improve quality of life and reduce the mortality. Here, we evaluated the effectiveness of a cross-linked hyaluronic acid (HA) as plastic bulking-agent filling and remodelling the deep dermis and subcutaneous space of the skin areas exposed to the risk of necrosis. Our work hypothesis has been to inflate a sub-dermal elastic cushion, filled with a natural ECM component, with the aim to induce a stronger tissue background resistant to the ulcerative process. Method: All the patients had an increased risk of PUs, at the sacral, ileum or heel skin. Patients were being nursed accordingly to the standard orthopaedic ward management with a pressure relieveing air mattress. The standard protocol consisted in body mobilisation every 3 hours, 24 hours a day and accurate cleaning of the skin with liquid soap and water without any towel friction and without adding any cream or lotion for the skin protection. Our filling protocol enclosed: accurate disinfection of the skin to be injected with povidone-iodine solution, followed by a local anaesthesia with 28G 13 mm needle, injecting 1.5 ml of 1% xylocaine. Then slow, deep, subcutaneous injection of cross-linked HA was performed with a 18G long needle, in order to deliver a homogeneous, soft gel layer underneath and around the whitish erythematous skin edges at risk of ulceration. Patients' tolerability of the compound and adverse events were also recorded. Results: There were 15 patients (78–94 years old) who participated in the study. All tolerated the procedure very well and no serious side effects were declared. No skin pressure ulceration was detected in the four weeks follow-up Conclusion: We have demonstrated the safety and tolerability of a cross-linked HA subdermal injection in PUs prevention. The compound stratifies in a soft, elastic, interstitial bulk into the deep dermis, thus reducing the exogenous pressure stress: thus, the induction of a thick hydrophilic substrate supports adequate mesenchymal and blood cells traffic to immediately restore any early or impending damage to the skin. Declaration of interest: The authors certify that there is no conflict of interest with any financial organisation regarding the material discussed in the manuscript.
Masculinity, masquerade and display: Some thoughts on Rick Owens’s Sphinx collection and men in fashion
Authors: Bancroft Alison 
Published: July 2016

Abstract
The ideas in this article stem from my earlier work on fashion and femininity and were prompted by the fashion designer Rick Owens’s Sphinx collection at Paris Men’s Fashion Week in January 2015. This controversial collection was a highlight of the fashion industry’s menswear shows, and garnered almost as much attention as the womenswear shows usually do. I contend that fashion is and remains a feminine cultural form, regardless of the anatomy of the wearer, with the proviso that the feminine is, or can be, a site of resistance. The question I want to address here is, what are male bodies on display actually saying, not just in the Rick Owens show, but in fashion more widely? My answer to that question draws heavily upon the psychoanalytic theories of Jacques Lacan, and deploys them to an analysis of the work of Rick Owens. My study of this collection draws heavily on the psychoanalytic writings of Jacques Lacan in its theorizing of contemporary men’s fashion shows, and takes as its point of departure the idea that fashion is inherently feminine, and thus always feminizing.
The Not-It girl
Authors: Morel Geneviève 
Published: July 2016

Abstract
This article presents an analysis of Clara Bow’s portrayal of the first It girl, a concept invented by the writer Elinor Glyn, in the silent movie It (Clarence E. Badger, 1927). This figure was to have an enduring, or at least recurrent, media future. The It girl is contrasted with another and opposite representation, which appeared in the same year, 1927, in the short story ‘Illusion’, by Jean Rhys. This story presents a different figure of fashion, a woman who does not show what she has; a woman who keeps her femininity hidden in the secret of the wardrobe. This type of woman, who dresses in a nondescript ‘normcore’ way, is frequently encountered in the psychoanalytic clinic, and is designated in the article as the Not-It girl.
Through analysis of the two contrasting fictional representations and consideration of a case history from her own psychoanalytic practice, the author draws on Freudian and Lacanian psychoanalytic formulations to consider what is going on in these two contrasted representations – and lived experiences – of femininity. The article concludes that the Not-It girl’s constant search for femininity (or its trappings) supports the fashion industry far more than the It girl ever does.
Jewish wigs and Islamic sportswear: Negotiating regulations of religion and fashion
Authors: Tarlo Emma 
Published: July 2016

Abstract
This article explores the dynamics of freedom and conformity in religious dress prescriptions and fashion, arguing that although fashion is popularly perceived as liberating and religion as constraining when it comes to dress, in reality both demand conformity to normative expectations while allowing some freedom of interpretation. The article goes on to trace the emergence of new forms of fashionable religious dress such as the human-hair wigs worn by some orthodox Jewish women and the new forms of Islamic sportswear adopted by some Muslim women. It shows how these fashions have emerged through the efforts of religiously observant women to subscribe simultaneously to the expectations of fashion and religious prescription, which are seen to operate in a relationship of creative friction. In doing so, they invent new ways of dressing that push the boundaries of religious and fashion norms even as they seek to conform to them.
Mine is Yours: Diotima’s Theory of Survival
Authors: Honda Masaya 
Published: July 2016

Abstract
This paper revives a series of discussions held in mid-twentieth century about Plato’s Symposium and, based on this, provides a logical basis for a potential theory on virtue ethics, which holds that naturalism is consistent with evolutionary biology. Specifically, this paper demonstrates how Diotima (who is described as young Socrates’s teacher on love, or eros) could defend her theory of identity vis-à-vis how humans naturally tend to survive in ways characteristic of their species over time.
The Limits of a Basic Income: Means and Ends of Workplace Democracy
Authors: Gourevitch Alex 
Published: July 2016

AbstractA democratic economy matters for different reasons, depending on why we are concerned about authoritarian workplaces. Authoritarian work conditions violate overlap but distinct values, related to democratic government, meaningful work, non-domination, exploitation, and the quality of leisure time. To the degree that democratizing work is supposed to advance these values, a basic income is neither a necessary nor sufficient condition for eliminating authoritarian work conditions. It might, in some conditions, reduce some of the worst aspects of our current workplace relationships. But, by the same token, it might exacerbate them, especially if a basic income becomes a substitute for collective self-organization by workers. In nearly every case, the value that we seek to advance and the kind of democratized economy we might wish to have is better created and maintained by concerted class power than by welfarist social policies, like a basic income.
Thermal rectification based on phonon hydrodynamics and thermomass theory
Authors: Dong Yuan 
Published: July 2016

Abstract
The thermal diode is the fundamental device for phononics. There are various mechanisms for thermal rectification, e.g. different temperature dependent thermal conductivity of two ends, asymmetric interfacial resistance, and nonlocal behavior of phonon transport in asymmetric structures. The phonon hydrodynamics and thermomass theory treat the heat conduction in a fluidic viewpoint. The phonon gas flowing through the media is characterized by the balance equation of momentum, like the Navier-Stokes equation for fluid mechanics. Generalized heat conduction law thereby contains the spatial acceleration (convection) term and the viscous (Laplacian) term. The viscous term predicts the size dependent thermal conductivity. Rectification appears due to the MFP supersession of phonons. The convection term also predicts rectification because of the inertia effect, like a gas passing through a nozzle or diffuser.
A study of the interactions between uniform and pointwise vortices in an inviscid fluid
Authors: Riccardi Giorgio 
Published: July 2016

Abstract
The planar interactions between pair of vortices in an inviscid fluid are analytically investigated, by assuming one of the two vortices pointwise and the other one uniform. A novel approach using the Schwarz function of the boundary of the uniform vortex is adopted. It is based on a new integral relation between the (complex) velocity induced by the uniform vortex and its Schwarz function and on the time evolution equation of this function. They lead to a singular integrodifferential problem. Even if this problem is strongly nonlinear, its nonlinearities are confined inside two terms, only. As a consequence, its solution can be analytically approached by means of successive approximations. The ones at 0th (nonlinear terms neglected) and 1st (nonlinear terms evaluated on the 0-order solution) orders are calculated and compared with contour dynamics simulations of the vortex motion. A satisfactory agreement is keept for times which are small with respect to the turn-over time of the vortex pair.
Uniformization of p-adic curves via Higgs–de Rham flows
Authors: Lan Guitang , Sheng Mao , Yang Yanhong , Zuo Kang 
Published: July 2016

Abstract
Let k be an algebraic closure of a finite field of odd characteristic. We prove that for any rank two graded Higgs bundle with maximal Higgs field over a generic hyperbolic curve

X
1

{X_{1}}

defined over k, there exists a lifting X of the curve to the ring

W
⁢

(
k
)

{W(k)}

of Witt vectors as well as a lifting of the Higgs bundle to a periodic Higgs bundle over

X
/
W

⁢

(
k
)

{X/W(k)}

. These liftings give rise to a two-dimensional absolutely irreducible representation of the arithmetic fundamental group

π
1

⁢

(

X
K

)

{\pi_{1}(X_{K})}

of the generic fiber of X. This curve X and its associated representation is in close relation to the canonical curve and its associated canonical crystalline representation in the p-adic Teichmüller theory for curves due to S. Mochizuki. Our result may be viewed as an analogue of the Hitchin–Simpson’s uniformization theory of hyperbolic Riemann surfaces via Higgs bundles.
Framing Bottled Water: A Comparative Reflection on the Legal Paradigm
Authors: Bonetto Diego 
Published: July 2016

AbstractThe work compares two apparently different legal frameworks governing bottled water to highlight the underlying convergence of their rhetorical underpinnings. In particular, it looks at the law regulating the exploitation of water destined to bottling in India and Italy. Through these two examples this work wants to show how in both countries, which may serve as, respectively, a Global South and a Global North examples as to their position in the worldwide allocation of economic wealth and labour, the regulations treat water as a commodity focusing on the aspects concerning its commercialization by private companies.
Dipeptidyl peptidase 9 substrates and their discovery: current progress and the application of mass spectrometry-based approaches
Authors: Wilson Claire H. , Zhang Hui Emma , Gorrell Mark D. , Abbott Catherine A. 
Published: July 2016

Abstract
The enzyme members of the dipeptidyl peptidase 4 (DPP4) gene family have the very unusual capacity to cleave the post-proline bond to release dipeptides from the N-terminus of peptide/protein substrates. DPP4 and related enzymes are current and potential therapeutic targets in the treatment of type II diabetes, inflammatory conditions and cancer. Despite this, the precise biological function of individual dipeptidyl peptidases (DPPs), other than DPP4, and knowledge of their in vivo substrates remains largely unknown. For many years, identification of physiological DPP substrates has been difficult due to limitations in the available tools. Now, with advances in mass spectrometry based approaches, we can discover DPP substrates on a system wide-scale. Application of these approaches has helped reveal some of the in vivo natural substrates of DPP8 and DPP9 and their unique biological roles. In this review, we provide a general overview of some tools and approaches available for protease substrate discovery and their applicability to the DPPs with a specific focus on DPP9 substrates. This review provides comment upon potential approaches for future substrate elucidation.
The Future of Resources: A New Chapter
Authors: Benedikter Roland , Kühne Kjell , Benedikter Ariane , Atzeni Giovanni 
Published: July 2016

AbstractPower struggles for resources are playing an increasingly crucial role behind the scenes, often covered by diplomacy or goodwill rhetoric. The question after the Paris Agreement of the United Nations Framework Convention on Climate Change (UNFCCC) of December 2015 is: Will new global civil society movements play a post-traditional and mediating role between the classical resource-securing strategies of the great powers and thus pave the way towards more connected, integrated and sustainable futures in the resource sector? What role will in particular – as a potential forerunner of others – play the global “Keep it in the Ground” Initiative, which aims at leaving the resources in the ground instead of using them? This essay gives an overview of the current situation and offers an alternative way forward.
Auswirkungen und Inanspruchnahme neuer Regelungen im Rahmen der Novelle des Genossenschaftsgesetzes von 2006
Authors: Blome-Drees Johannes , Degens Philipp , Schimmele Clemens 
Published: July 2016

Zusammenfassung
Im vorliegenden Beitrag werden empirische Ergebnisse einer vom Bundesministerium für Wirtschaft und Energie zum Thema „Potenziale und Hemmnisse von unternehmerischen Aktivitäten in der Rechtsform der Genossenschaft“ in Auftrag gegebenen Studie dahingehend vorgestellt, ob und in welchem Ausmaß die durch die Novelle von 2006 eingeführten neuen Regelungen im Genossenschaftsgesetz von Genossenschaften tatsächlich genutzt und ob die intendierten Ziele der Novelle erreicht werden.
Международный трансфер знаний в условиях глобализации мировой экономики
Authors: Makohon Y. V. , Medvedkin T. S. 
Published: July 2016

В условиях перехода глобальных экономических систем к экономике знаний путем внедрения инновационных моделей хозяйствования знания приобретают статус ключевого товара и превращаются в важнейший фактор формирования конкурентных преимуществ субъектов мировых рынков. С развитием научной сферы интенсифицировалась торговля инновациями и инновационными продуктами, основой которых являются результаты НИОКР. При этом не все субъекты рынков научно-технической продукции располагают достаточными финансовыми ресурсами для проведения фундаментальных исследований, способных обеспечить появление принципиально новых разработок, что становится причиной интенсификации процесса трансфера знаний.
Розвиток інноваційної енергетики в глобальному та регіональному вимірах
Authors: Dzhusov O. A. , Gladchenko A. Y. 
Published: July 2016

Генералізовано основні регіональні організації, які тією чи іншою мірою впливають на розвиток альтернативної енергетики, на основі аналізу їх ролі, повноважень та впливу на прийняття рішень. Виявлено їх вплив на розвиток інноваційної складової енергетичної сфери країн світової економіки.