bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pharmacokinetics of Pregabalin in Breast Milk, Plasma, and Urine of Healthy Postpartum Women
Authors: Lockwood Peter A. , Pauer Lynne , Scavone Joseph M. , Allard Maud , Mendes da Costa Laure , Alebic-Kolbah Tanja , Plotka Anna , Alvey Christine W. , Chew Marci L. 
Published: March 2016

Background: Limited data exist on the presence of pregabalin in human breast milk of nursing mothers. Objectives: This study aimed to determine pregabalin concentrations in breast milk, estimate the infant daily pregabalin dose from nursing mothers, and evaluate pregabalin pharmacokinetic data in lactating women (≥ 12 weeks postpartum). Methods: In this multiple-dose, open-label, pharmacokinetic study, 4 doses of pregabalin 150 mg were administered orally at 12-hour intervals. Urine, blood, and breast milk samples were collected up to 12, 24, and 48 hours, respectively, following the fourth dose. Pharmacokinetic parameters were estimated using noncompartmental methods. Adverse events were monitored throughout. Results: Ten healthy lactating women (age 24-37 years) received pregabalin. Geometric mean pregabalin Cmaxss and AUCτ values in breast milk were approximately 53% and 76%, respectively, of those for plasma. The mean amount of pregabalin in breast milk recovered in a 24-hour period after the last dose was 574 μg (range, 270-1720 μg), which is approximately 0.2% of the administered daily maternal dose of 300 mg. The estimated average daily infant dose of pregabalin from breast milk was 0.31 mg/kg/day, which would be approximately 7% (23% coefficient of variation) of the body weight normalized maternal dose. Approximately 89% of the dose administered was recovered in urine. Renal clearance averaged 68.2 mL/min. Adverse events were of mild or moderate severity. Conclusion: Lactation appears to have had little influence on pregabalin pharmacokinetics. Overall, the estimated dose of pregabalin in breastfed children of women receiving pregabalin is low. Pregabalin was well tolerated in lactating women. Declaration of Conflicting Interests The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Peter A. Lockwood, Lynne Pauer, Joseph M. Scavone, Maud Allard, Laure Mendes da Costa, Tanja Alebic-Kolbah, Anna Plotka, Christine W. Alvey, and Marci L. Chew were all full-time employees of Pfizer at the time the study was completed and hold stock and/or stock options in Pfizer. Funding The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was sponsored by Pfizer, which was involved in the study design, the collection, analysis, and interpretation of the data, the writing of the report, and the decision to submit the paper for publication. Medical writing support was provided by Penny Gorringe, MSc, of Engage Scientific Solutions and funded by Pfizer.
A new reliability based optimization of tuned mass damper parameters using energy approach
Authors: Mrabet Elyes , Guedri Mohamed , Ichchou Mohamed Najib , Ghanmi Samir , Soula Mohamed 
Published: March 2016

In this work a reliability based optimization (RBO) strategy of Tuned Mass Damper (TMD) parameters is presented. The strategy is based on an energetic approach. The strategy consists to optimize the TMD parameters so that we minimize the failure probability (objective function) characterized by the exceedence of the power dissipated in the primary structure of a certain threshold value during some interval time. The evaluation of the objective function is carried out using the classical Rice’s formula. The strategy is, firstly, applied to linear single-degree of freedom (SDOF) system, subjected to seismic motion, and then extended to linear multi-degree of freedom (MDOF) system. The use of the Rice’s formula requires the knowledge of the joint probability density function (PDF) of the considered processes; to this end, exact expression of the joint PDF is presented for the SDOF system and an approximation is presented for the evaluation of the failure probabilities for the MDOF system. By making use of the obtained joint PDF, for the SDOF system, as the a priori joint PDF, the approximation of the joint PDF, for the MDOF system, has been performed using the Minimum cross-entropy method (MinxEnt). To highlight the good effectiveness of the proposed strategy, a ten-story shear building, subjected to different earthquakes, is considered. The obtained results are compared with other from literature, and it has been shown the superiority of the proposed strategy.
Computed tomography, radiology and echocardiography in cats naturally infected with Aelurostrongylus abstrusus
Authors: Lacava Giuseppe , Zini Eric , Marchesotti Federica , Domenech Oriol , Romano Francesca , Manzocchi Simone , Venco Luigi , Auriemma Edoardo 
Published: March 2016

Objectives The aims of the study were to describe the radiographic and computed tomographic features in cats naturally infected with Aelurostrongylus abstrusus, and to identify signs of pulmonary hypertension with echocardiography. Methods Fourteen cats positive on Baermann test for A abstrusus were included in the study. All cats underwent thoracic radiography, CT and echocardiography. Results The most common clinical signs were coughing (10/14) and dyspnoea (5/14). Radiographic findings included a generalised unstructured interstitial pulmonary pattern (8/14), mixed bronchointerstitioalveolar pattern (3/14) and bronchointerstitial pattern with bronchial wall thickening (3/14). Sternal lymphadenopathy was detected on thoracic radiographs in six cats. On CT, features were mixed bronchointerstitioalveolar pattern with ground-glass appearance in six cats, interstitioalveolar with multiple pulmonary nodules in five, interstitial ground-glass infiltrates in three, regional lymph node enlargement in 11 (10 sternal, three cranial mediastinal and three tracheobronchial lymph nodes) and subpleural thickening in four. None of the thoracic radiographs revealed subpleural thickening. In all cases, pulmonary vessels were normal in terms of size, shape and attenuation on both radiography and CT. Pulmonary hypertension and cardiac abnormalities were not observed in any cat during echocardiography. Conclusions and relevance CT provided a more thorough characterisation of pulmonary and mediastinal lesions compared with thoracic radiographs in cats naturally infected with A abstrusus. Although feline aelurostrongylosis has been previously associated with histopathological lesions in lung arteries, in this cohort clinical evidence of pulmonary hypertension was not documented.
Accreditation in Primary Health: RACGP Standards for General Practice
Authors: Hili Halina 
Published: March 2016

General Practitioners play a crucial role as “gate-keepers” to the health system. In this context, they have a profound influence on both health outcomes and health expenditure. Since the introduction in 1999 of a formal, peer-driven external accreditation process, over 4,590 Australian general practices have achieved full accreditation. The process of re-ccreditation has commenced, subsequent to a review of the original standards, and with an ongoing focus on continuous quality improvement. This article describes a typical accreditation survey visit, and explains the accreditation criteria and how they are reviewed by the surveyors. There is discussion also of the impact of this new accreditation system on general practice.
Speech Recognition in the Radiology Department: A Systematic Review
Authors: Hammana Imane , Lepanto Luigi , Poder Thomas , Bellemare Christian , Ly My-Sandra 
Published: March 2016

Objective: to conduct a systematic review of the literature describing the impact of speech recognition systems on report error rates and productivity in radiology departments. Methods: The search was conducted for relevant papers published from January 1992 to October 2013. Comparative studies reporting any of the following outcomes were selected: error rates, departmental productivity, and radiologist productivity. The retrieved studies were assessed for quality and risk of bias. Results: The literature search identified 85 potentially relevant publications, but, based on the inclusion and exclusion criteria, only 20 were included. Most studies were before and after assessments with no control group. There was a large amount of heterogeneity due to differences in the imaging modalities assessed and the outcomes measured. The percentage of reports containing at least one error varied from 4.8% to 89% for speech recognition, and from 2.1% to 22% for transcription. Departmental productivity was improved with decreases in report turnaround times varying from 35% to 99%. Most studies found a lengthening of radiologist dictation time. Conclusion: Overall gains in departmental productivity were high, but radiologist productivity, as measured by the time to produce a report, was diminished.
The Role of Information and Communication Technology in the Transformation of the Healthcare Business Model: A Case Study of Slovenia
Authors: Stanimirovic Dalibor , Vintar Mirko 
Published: March 2016

Background: The Slovenian healthcare business model (BM) has largely failed to integrate information and communication technologies (ICT) into its operational context, instead maintaining its rigid structure and traditional ‘way of doing business’. This situation often results in uncoordinated business operations, while additionally destabilising an already underfinanced healthcare system and compromising the general quality of healthcare. Aim: The aim of this study is to provide an analysis of the BM concept and its implications, and to identify the potential effects of informatisation on the existing healthcare BM in Slovenia. Based on the findings, the paper concludes by presenting a conceptualisation of a transformed healthcare BM adapted to the Slovenian healthcare environment. Method: The study employs a single explanatory/exploratory case study design, while the validation of the hypothesised constructs was undertaken through structured interviews with twelve prominent experts from the Slovenian healthcare system. Interviewees were: healthcare professionals (two general practitioners and two specialists), ICT experts from healthcare (one ICT consultant and three analysts), and healthcare managers (two managers of public healthcare centres and two managers of public clinics). Results: Findings present a roadmap for the redefinition of BM elements and the transformation of the Slovenian healthcare BM. It includes the specific reconfiguration of BM actors and their interactions, and the application of advanced ICT solutions, which could facilitate more effective utilisation of healthcare resources and promote an improved delivery of healthcare services and products. Conclusion: The presented development approach and derived conceptual solution could be transferable to other countries with similar socio-economic characteristics and comparable healthcare systems, subject to certain adjustments and inclusion of national specifics.
Data Quality Associated with Handwritten Laboratory Test Requests: Classification and Frequency of Data-Entry Errors for Outpatient Serology Tests
Authors: Vecellio Elia , Maley Michael W. , Toouli George , Georgiou Andrew , Westbrook Johanna 
Published: March 2016

Objective: Manual data-entry of handwritten laboratory test requests into electronic information systems has implications for data accuracy. This study sought to identify the types and number of errors occurring for handwritten serology test requests received from outpatient clinics. Methods: A 15-day audit at a serology laboratory in Sydney, Australia, compared the content of all transcribed serology outpatient test requests in the laboratory information system with the handwritten request form. Results: One or more errors were detected in 67/627 (10.7%) audited requests ( N=68 errors). Fifty-one of the errors (75.0%) were transcription errors: the wrong test was transcribed in 40/68 cases (58.8%) – ten of these occurred when the abbreviations ‘HBsAb’ and ‘HBsAg’ were confounded for one another – and transcribed requests were missing a test in 11/68 cases (16.2%). The remaining 17 non-transcription errors (25.0%) described request forms not signed by the ordering clinician, mislabelled specimens, and wrong tests due to computer algorithm errors. Conclusions: Manual data-entry of handwritten serology requests is an error-prone process. Electronic ordering has the potential to eliminate illegible handwriting and transcription errors, thus improving data accuracy in hospital information systems.
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation
Authors: Avellino Roberto , Havermans Marije , Erpelinck Claudia , Sanders Mathijs A. , Hoogenboezem Remco , van de Werken Harmen J. G. , Rombouts Elwin , van Lom Kirsten , van Strien Paulina M. H. , Gebhard Claudia , Rehli Michael , Pimanda John , Beck Dominik , Erkeland Stefan , Kuiken Thijs , de Looper Hans , Gröschel Stefan , Touw Ivo , Bindels Eric , Delwel Ruud 
Published: March 2016

Key Points
The CEBPA locus harbors 14 enhancers of which distinct combinations are active in different CEBPA-expressing tissues. A +42-kb enhancer is required for myeloid-lineage priming to drive adequate CEBPA expression levels necessary for neutrophilic maturation.
A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus
Authors: Simitsidellis Ioannis , Gibson Douglas A. , Cousins Fiona L. , Esnal-Zufiaurre Arantza , Saunders Philippa T. K. 
Published: March 2016

Abstract
The endometrium consists of stromal and epithelial compartments (luminal and glandular) with distinct functions in the regulation of uterine homeostasis. Ovarian sex steroids, namely 17β-estradiol and progesterone, play essential roles in modulating uterine cell proliferation, stromal-epithelial cross-talk and differentiation in preparation for pregnancy. The effect of androgens on uterine function remains poorly understood. The current study investigated the effect of the non-aromatizable androgen dihydrotestosterone (DHT) on mouse endometrial function. Ovx female mice were given a single sc injection (short treatment) or 7 daily injections (long treatment) of vehicle alone (5% ethanol, 0.4% methylcellulose) or vehicle with the addition of 0.2 mg DHT (n=8/group) and a single injection of bromodeoxyuridine 2 hours prior to tissue recovery. Treatment with DHT increased uterine weight, the area of the endometrial compartment and immunoexpression of the androgen receptor in the luminal and glandular epithelium. Treatment-dependent proliferation of epithelial cells was identified by immunostaining for MKi67 and bromodeoxyuridine. Real-time PCR identified significant DHT-dependent changes in the concentrations of mRNAs encoded by genes implicated in the regulation of the cell cycle (Wee1, Ccnd1, Rb1) and stromal-epithelial interactions (Wnt4, Wnt5a, Wnt7a, Cdh1, Vcl, Igf1, Prl8, Prlr) as well as a striking effect on the number of endometrial glands. This study has revealed a novel role for androgens in regulating uterine function with an effect on the glandular compartment of the endometrium. This previously unrecognized role for androgens has implications for our understanding of the role of androgens in regulation of endometrial function and fertility in women.
Association of Mutations in SLC12A1 Encoding the NKCC2 Cotransporter With Neonatal Primary Hyperparathyroidism
Authors: Li Dong , Tian Lifeng , Hou Cuiping , Kim Cecilia E. , Hakonarson Hakon , Levine Michael A. 
Published: March 2016

Abstract

Context:
Primary hyperparathyroidism with hypercalciuria has not been described in the newborn period.

Objective:
Our objectives are to identify the genetic basis for neonatal primary hyperparathyroidism in a family with 2 affected children.

Subjects:
An African American boy presenting with mild neonatal primary hyperparathyroidism and hypercalciuria was evaluated at The Children's Hospital of Philadelphia. His older brother with neonatal primary hyperparathyroidism had died in infancy of multiple organ failure.

Methods:
We collected clinical and biochemical data and performed exome sequencing analysis on DNA from the patient and his unaffected mother after negative genetic testing for known causes of primary hyperparathyroidism.

Results:
Exome sequencing followed by Sanger sequencing disclosed 2 heterozygous mutations, c.1883C&gt;A, p.(A628D) and c.2786_2787insC, p.(T931fsX10), in the SLC12A1 gene, which was previously implicated in antenatal type 1 Bartter syndrome. Sanger sequencing confirmed the 2 mutations in the proband and his deceased brother; both parents were heterozygous for different mutations and an unaffected sister was homozygous for wild-type alleles.

Conclusions:
These results demonstrate a previously unrecognized association between neonatal primary hyperparathyroidism and mutation of SLC12A1, the cause of antenatal Bartter syndrome type 1, and suggest that the loss of sodium-potassium-chloride cotransporter-2 cotransporter activity influences parathyroid gland function.
The identity of Acarospora xanthophana (Fungi: Ascomycota) and a description of A. congregata sp. nov. to accommodate a widely distributed saxicolous species occurring in the higher elevations of South America
Authors: Knudsen Kerry , Flakus Adam 
Published: March 2016

AbstractAcarospora rhabarbarina Hue, published as a replacement name for the later homonym Lecanora bella Nyl., is an illegitimate superfluous name because Nylander had previously published his own replacement name, L. xanthophana (≡ A. xanthophana (Nyl.) Jatta). Furthermore, Hue, Magnusson and other later authors misapplied the name A. xanthophana to a common South American taxon, which is described here as A. congregata, the epithet referring to the usual arrangement of the apothecia in groups in large areoles. Lecanora ochrophana Nyl., a synonym of A. xanthophana, is lectotypified. The question of conservation of names, including an explanation as to why it is not proposed in this case, is discussed.
Analysis of the cosmopolitan buckthorn genera Frangula and Rhamnus s.l. supports the description of a new genus, Ventia
Authors: Hauenschild Frank , Favre Adrien , Salazar Gerardo A. , Muellner-Riehl Alexandra N. 
Published: March 2016

AbstractThe taxonomy of the species‐rich and widespread Rhamnus s.l. is partially unresolved. While Frangula is morphologically similar to Rhamnus but separate according to previous molecular studies, the delimitation of sections within Rhamnus s.str., including the large Rhamnus sect. Rhamnus, remains unclear. In order to clarify the taxonomy of Rhamnus, we present the largest molecular dataset available to date, including ITS and trnL‐trnF sequences of 103 species. fasttree‐like searches, maximum likelihood estimates and Bayesian analyses were performed and compared. Our results are congruent across all analyses and show that the current subdivision of Rhamnus s.1. should be extended from two (Frangula, Rhamnus) to four distinct genera. First, we exclude six species from Rhamnus and attribute them to the new genus Ventia. Second, we raise the entire Rhamnus sect. Oreoherzogia to generic level. Finally, we confirm the monophyly of Rhamnus sect. Alaternus and R. sect. Rhamnus within Rhamnus s.str.
Care Certificate Standards 9 and 10: mental health, dementia and learning disabilities; and safeguarding adults
Authors: Peate Ian 
Published: March 2016

In all spheres of your work, you will meet people with mental health problems, dementia and learning disability and you will be expected to have an awareness of these issues. This article discusses two of the care standards: standard 9, mental health, dementia, and learning disabilities. Those with mental health conditions, dementia and learning disability will have unique needs. The HCA and AP must consider the individual from a physical, psychological and social perspective. The standard that considers the safeguarding of adults is standard 10. A brief discussion of the key issues associated with mental health, dementia and learning disabilities and safeguarding adults is provided.
A Robust Weak Galerkin Finite Element Method for Linear Elasticity with Strong Symmetric Stresses
Authors: Chen Gang , Xie Xiaoping 
Published: March 2016

Abstract
This paper proposes
and analyzes a weak Galerkin (WG) finite element method with strong symmetric stresses for two- and three-dimensional linear elasticity problems on conforming or nonconforming polygon/polyhedral meshes. The WG method uses piecewise-polynomial approximations of degrees k (

≥
1

${\geq 1}$

) for the stress,

k
+
1

${k+1}$

for the displacement, and k for the displacement trace on the inter-element boundaries.
It is shown to be equivalent to a hybridizable discontinuous Galerkin (HDG) finite element scheme. We show that the WG methods are robust in the sense that the
derived a priori error estimates are optimal and uniform with respect to the Lamé constant λ.
Numerical experiments confirm the theoretical results.
The space of compact self-shrinking solutions to the Lagrangian mean curvature flow in ℂ2{\mathbb{C}^{2}}
Authors: Chen Jingyi , Ma John Man Shun 
Published: March 2016

Abstract
Let

F
n

F_{n}

: (Σ,

h
n

h_{n}

)

→

\to

ℂ
2

\mathbb{C}^{2}

be a sequence of conformally immersed Lagrangian self-shrinkers with a uniform area upper bound to the mean curvature flow, and suppose that the sequence of metrics

{

\{

h
n

h_{n}

}

\}

converges smoothly to a Riemannian metric h. We show that a subsequence of

{

\{

F
n

F_{n}

}

\}

converges smoothly to a branched conformally immersed Lagrangian self-shrinker

F
∞

F_{\infty}

: (Σ, h)

→

\to

ℂ
2

\mathbb{C}^{2}

. When the area bound is less than 16π, the limit

F
∞

{F_{\infty}}

is an embedded torus. When the genus of Σ is one, we can drop the assumption on convergence

h
n

h_{n}

→

\to

h. When the genus of Σ is zero, we show that there is no branched immersion of Σ as a Lagrangian self-shrinker, generalizing the rigidity result of [21] in dimension two by allowing branch points.
d-orthogonality and q-Askey-scheme
Authors: Lamiri Imed , Ouni Abdelwaheb 
Published: March 2016

Abstract
In this work, by solving a d-Geronimus problem we introduce new examples of basic hypergeometric d-orthogonal polynomials which are useful
to construct a similar table to the q-Askey-scheme in the context of d-orthogonality.
For d = 1, this leads to a characterization theorem involving all polynomials belonging to the q-Askey-scheme, except the continuous q-Hermite ones.
The Corrosion Behaviors of the Cerium Conversion Coatings on the Zinc Coating in a 5 % NaCl Solution
Authors: Zhang Jianghong , Meng Binfang , Wang Xinying , Li Wei 
Published: March 2016

Abstract
The present paper investigated the impact of cerium on the corrosion resistance of zinc coating in a 5 % NaCl solution. Electrochemistry was used to measure the electrochemical parameters to compare the corrosion resistance of the zinc coating with that of the cerium conversion coating on the galvanized layer. SEM/EDS and XRD were adopted to analyze the appearance and phases of corrosion products of the cerium conversion coating and to probe the impact of cerium on the corrosion behavior of zinc coating in the Cl– media. The results showed that the cerium conversion coating formed on the zinc coating increased the zinc’s corrosion resistance effectively, conversion coating with lower cerium content protected the substrate poorly, resulting in easy erosion of the zinc coating in the Cl– media. The corrosion products mainly consist of complexes, such as Zn(OH)xCly and Ce(OH)xCly.