Physicians' reasons not to discontinue long‐term used off‐label antipsychotic drugs in people with intellectual disability
Authors: de Kuijper G. M. , Hoekstra P. J. 
Published: May 2017

AbstractBackgroundPeople with intellectual disability (ID) frequently use antipsychotic drugs on an off‐label base, often for many years. Physicians' decisions to discontinue these drugs not only depend on patient characteristics, like the presence of mental or behavioural disorders, but also on environmental factors, such as inappropriate living circumstances, and on attitudes, knowledge and beliefs of staff, clients and their representatives towards the effects of antipsychotic drug use. In this study, we therefore investigated the influence of participant and setting‐related factors on decisions of physicians not to discontinue off‐label prescribed antipsychotics.MethodsThe study took place in living facilities of six service providers for people with ID spread over the Netherlands and staffed with support professionals, nurses, behavioural scientist and physicians and was part of an antipsychotics discontinuation trial. ID physicians had to decide whether the off‐label use of antipsychotics could be discontinued.Medical and pharmaceutical records were used to establish the prevalence of antipsychotic drug use in the study population, along with duration of use and whether the use was off‐label. Reasons of physicians not to discontinue the prescription of antipsychotics in those participants who used off‐label antipsychotics for more than a year were collected and categorised as related to participant or setting characteristics, including lack of consent to discontinue, and staff members, participants or their legal representatives.ResultsOf the 3299 clients of the service providers, 977 used one or more antipsychotic drugs. The prevalence of antipsychotic drug use was 30%. Reasons for use were in 5% of cases, a chronic psychotic disorder classified according to Diagnostic System Mental Disorders, Fourth Edition, criteria, in 25%, present or past (suspected) non‐schizophrenia‐related psychotic symptoms and in 69%, challenging behaviours. Overall, physicians were willing to discontinue their prescriptions in 51% of cases, varying from 22% to 87% per service provider. The odds for decisions of physicians to discontinue off‐label prescriptions varied from 0.19 to 13.95 per service provider. The variables ‘a living situation with care and support’ and ‘challenging behaviour’ were associated with a higher chance of discontinuation.The main reasons for decisions not to discontinue were concerns for symptoms of restlessness, the presence of an autism spectrum disorder, previously unsuccessful attempts to discontinue and objections against discontinuation of legal representatives. Reasons for physicians' decisions not to discontinue the off‐label use of antipsychotics varied largely between the service providers.ConclusionsThe prevalence of antipsychotic drug use for off‐label indications in people with ID remains high. The results of this study indicate that there is a large variation in clinical practice of physicians regarding discontinuation of long‐term antipsychotic drug prescriptions, which may be partially related to environmental factors as setting culture and attitudes of staff towards off‐label antipsychotic drug use in persons with ID.