bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular profiling of BRAF-V600E-mutant metastatic colorectal cancer in the phase 3 BEACON CRC trial
Authors: Kopetz Scott , Murphy Danielle A. , Pu Jie , Ciardiello Fortunato , Desai Jayesh , Van Cutsem Eric , Wasan Harpreet Singh , Yoshino Takayuki , Saffari Hedieh , Zhang Xiaosong , Hamilton Phineas , Xie Tao , Yaeger Rona , Tabernero Josep 
Published: September 2024

AbstractThe BEACON CRC study demonstrated that encorafenib (Enco)+cetuximab (Cetux)±binimetinib (Bini) significantly improved overall survival (OS) versus Cetux + chemotherapy in previously treated patients with BRAF-V600E-mutant mCRC, providing the basis for the approval of the Enco+Cetux regimen in the United States and the European Union. A greater understanding of biomarkers predictive of response to Enco+Cetux±Bini treatment is of clinical relevance. In this prespecified, exploratory biomarker analysis of the BEACON CRC study, we characterize genomic and transcriptomic correlates of clinical outcomes and acquired resistance mechanisms through integrated clinical and molecular analysis, including whole-exome and -transcriptome tissue sequencing and circulating tumor DNA genomic profiling. Tumors with higher immune signatures showed a trend towards increased OS benefit with Enco+Bini+Cetux. RAS, MAP2K1 and MET alterations were most commonly acquired with Enco+Cetux±Bini, and more frequent in patients with a high baseline cell-cycle gene signature; baseline TP53 mutation was associated with acquired MET amplification. Acquired mutations were subclonal and polyclonal, with evidence of increased tumor mutation rate with Enco+Cetux±Bini and mutational signatures (SBS17a/b). These findings support treatment with Enco+Cetux±Bini for patients with BRAF-V600E-mutant mCRC and provide insights into the biology of response and resistance to MAPK-pathway-targeted therapy. ClinicalTrials.gov registration: NCT02928224
Older adults are relatively more susceptible to impulsive social influence than young adults
Authors: Su Zhilin , Garvert Mona M. , Zhang Lei , Manohar Sanjay G. , Vogel Todd A. , Thomas Louisa , Balsters Joshua H. , Husain Masud , Apps Matthew A. J. , Lockwood Patricia L. 
Published: September 2024

AbstractPeople differ in their levels of impulsivity and patience, and these preferences are heavily influenced by others. Previous research suggests that susceptibility to social influence may vary with age, but the mechanisms and whether people are more influenced by patience or impulsivity remain unknown. Here, using a delegated inter-temporal choice task and Bayesian computational models, we tested susceptibility to social influence in young (aged 18–36, N = 76) and older (aged 60–80, N = 78) adults. Participants completed a temporal discounting task and then learnt the preferences of two other people (one more impulsive and one more patient) before making their choices again. We used the signed Kullback-Leibler divergence to quantify the magnitude and direction of social influence. We found that, compared to young adults, older adults were relatively more susceptible to impulsive social influence. Factor analyses showed that older adults with higher self-reported levels of affective empathy and emotional motivation were particularly susceptible to impulsive influence. Importantly, older and young adults showed similar learning accuracy about others’ preferences, and their baseline impulsivity did not differ. Together, these findings suggest highly affectively empathetic and emotionally motivated older adults may be at higher risk for impulsive decisions, due to their susceptibility to social influence.
Backward wave optical parametric oscillation in a waveguide
Authors: Mutter Patrick , Laurell Fredrik , Pasiskevicius Valdas , Zukauskas Andrius 
Published: September 2024

AbstractBackward wave oscillators represent a class of tunable sources of electromagnetic radiation that do not require a resonant cavity to satisfy the oscillation condition. In the optical regime, the Backward Wave Optical Parametric Oscillator (BWOPO) relies on a a nonlinear interaction to provide the positive feedback required for oscillation, achieved through quasi-phase matching with sub-micron periods. The unique properties of the BWOPO have so far been shown in bulk crystals only, but the absence of an optical resonator makes the BWOPO naturally suitable for integration in a waveguide format. We demonstrate the first waveguide BWOPO, showcasing an oscillation threshold nearly 20 times lower than the corresponding bulk device, and exhibiting low loss (0.2 dB/cm). The backward wave has a narrow linewidth of 21 GHz at 1514.6 nm, while the forward wave at 1688.7 nm has a broadband spectrum replicating that of the pump. A conversion efficiency of 8.4% was obtained.
A deep learning‐based approach for pseudo‐satellite positioning
Authors: Li Shuang , Wang Jiacheng , Yu Baoguo , Xing Hantong , Wang Shuang 
Published: September 2024

AbstractTraditional pseudo‐satellite‐based indoor positioning techniques are greatly affected by the presence of multipath effects, leading to a notable reduction in the positioning precision. In order to tackle this challenge, a pseudo‐satellite indoor positioning method based on deep learning is proposed. The method grids the localization region, thus transforming positioning from a regression problem to a classification problem in the gridded areas. 1D‐convolutional neural network is employed to extract the correlation between pseudo‐satellite data and the positioning of indoor areas. Data are collected and the method is validated in three types of areas of the experimental field, namely unobstructed area, semi‐unobstructed area and obstructed area. The experimental results demonstrate that the method exhibits superior positioning accuracy compared to traditional methods, enabling effective localization even in obstructed area.
Optimal pilot pattern for data‐aided channel estimation for MIMO‐OFDM wireless systems
Authors: Khan Inaamullah , Cheffena Michael 
Published: September 2024

AbstractThis article presents an optimal pilot pattern for the data‐aided channel estimation (DACE) scheme for both single‐input single‐output (SISO) and multiple‐input multiple‐output orthogonal frequency division multiplexing (MIMO‐OFDM) wireless systems. The research evaluates the performance of the DACE scheme using different comb‐type pilot patterns for both least square (LS) and linear minimum mean square error (LMMSE) channel estimators. In this regard, it is found that pilot spacing significantly influences system performance. Inserting pilot symbols in consecutive subcarriers cannot compensate for increased pilot spacing. Hence, the solution to this problem is to place pilot symbols at appropriate locations within the given spectrum. Moreover, data symbols which are reliably detected at the receiver are used as additional pilot signals to further enhance system performance. However, reliable data symbols need to be determined carefully because wrong detection results in severe performance degradation. In this respect, the proposed comb‐type pilot pattern using a single pilot subcarrier extracts the maximum number of reliable data symbols for the DACE scheme, improves channel estimation accuracy, and provides bandwidth optimization for MIMO‐OFDM systems. Furthermore, it outperforms all other pilot patterns in terms of system mean square error (MSE) and bit‐error‐rate (BER) performance.
Reconfigurable intelligent surface enabled programmable antenna chamber: Concept and preliminary experiments
Authors: Li Yifa , Zhang Fengchun , Olesen Kim , Ying Zhinong , Pedersen Gert Frølund , Fan Wei 
Published: September 2024

AbstractAntenna chambers are RF‐shielded enclosures which are required for antenna and radio performance measurements. Typically, anechoic chambers (ACs) are used for measuring directional metrics (e.g. antenna pattern, effective isotropic power etc.), while reverberation chambers (RCs) are widely used for non‐directional measurements (e.g. antenna efficiency, total radiated power etc.). When a device under test requires both types of measurements, testing needs to be conducted sequentially in an AC and an RC. This leads to significant time inefficiencies due to the need to set up and calibrate two separate measurement setups in two different chambers. To address these issues, this letter proposes a programmable chamber framework capable of electronically switching between AC and RC modes by programming the reflective intelligent surface‐enabled sidewalls. This framework is highly attractive for the industry as it supports both directional and non‐directional measurements within a single chamber. The letter outlines the conceptual framework, discusses design considerations, and presents preliminary experimental validation of reflective intelligent surface‐enabled sidewall with the designed phase‐setting configurations to emulate the radio absorber sidewall of an AC and the metal plate sidewall of an RC. The experimental results demonstrate the effectiveness and potential of the proposed approach.
Dunhuang mural inpainting based on reference guidance and multi‐scale fusion
Authors: Liu Zhongmin , Li Yaolong 
Published: September 2024

AbstractIn response to the inadequate utilization of prior information in current mural inpainting processes, leading to issues such as semantically unreliable inpaintings and the presence of artifacts in the inpainting area, a Dunhuang mural inpainting method based on reference guidance and multi‐scale feature fusion is proposed. First, the simulated broken mural, the mask image, and the reference mural are input into the model to complete the multi‐level embedding of patches and align the multi‐scale fine‐grained features of damaged murals and reference murals. Following the patch embedding module, a hybrid residual module is added based on hybrid attention to fully extract mural features. In addition, by continuing the residual concatenation of outputs of the hierarchical embedding module improves the ability of the model to represent deeper features, and improves the robustness and generalisation of the model. Second, the encoded features are fed into the decoder to generate decoded features. Finally, the convolutional tail is employed to propagate them and complete the mural painting. Experimental validation on the Dunhuang mural dataset demonstrates that, compared to other algorithms, this model exhibits higher evaluation metrics in the inpainting of extensively damaged murals and demonstrates overall robustness. In terms of visual effects, the results of this model in the inpainting process exhibit finer textures, richer semantic information, more coherent edge structures, and a closer resemblance to authentic murals.
Entwicklung und Validierung eines Fragebogens zur Erfassung der
Zufriedenheit von Patienten mit digitaler Bewegungstherapie
Authors: Krell Jan , Wulff Hagen 
Published: September 2024

Zusammenfassung
Zielsetzung Die digitale Transformation hat Einfluss auf das
Gesundheitswesen. Für die Konzeption und Optimierung digitaler Bewegungstherapie
besitzt das Konstrukt der Patientenzufriedenheit und die Entwicklung eines
Messmodells hohe Relevanz.
Methodik Die Entwicklung des Fragebogens erfolgte durch ein mehrstufiges
Verfahren. Eine Hauptkomponentenanalyse mit Daten von 180 Befragten (♀=71, ♂=90,
k.A.=19) diente zur Analyse der Struktur des Fragebogens. Die interne Konsistenz
der Skalen wurde durch Cronbachs Alpha und die Trennschärfe der Items durch
Item-Skala-Korrelationen geprüft.
Ergebnisse Fünf Dimensionen wurden aus dem initialen Itempool extrahiert.
Die Kenngrößen der internen Konsistenz (α=0,74) und
Item-Skala-Korrelation r > 0,30 waren zufriedenstellend bis hoch.
Schlussfolgerung Der validierte Fragebogen ermöglicht erstmals die
Erfassung der Zufriedenheit mit digitaler Bewegungstherapie, um Maßnahmen zu
optimieren und die Beantwortung weiterführender Forschungsfragen mit
Implikationen für Theorie (Zufriedenheitsmodellierung) und Transfer
(Qualifikation).
A Comparative Analysis of ADRs under Obeticholic Acid and
Ursodeoxycholic Acid in Cholestatic Liver Diseases Using the FAERS
Database
Authors: Zhu Meng , Tao Linghui , Zhu Feiye , Zhang Yongsheng 
Published: September 2024

Abstract
Background The objective of this study was to compare the safety profiles
of OCA and UDCA for the treatment of PBC using the FDA Adverse Event Reporting
System database.
Methods We extracted reports for OCA from 2016 to 2023 and UDCA from 2004
to 2023. Demographic details, adverse events (AEs), and concomitant medications
were analyzed using descriptive statistics and signal detection methods.
Results The most common for OCA were pruritus (1345 cases, ROR 20.96) and
fatigue (528 cases, ROR 3.46). UDCA was more frequently associated with
hepatocellular carcinoma (22 cases, ROR 16.37) and type I hypersensitivity
reactions (11 cases, ROR 12.77). OCA was also linked to a higher frequency of
constipation (161 cases, ROR 3.92) and increased blood alkaline phosphatase
levels (145 cases, ROR 44.27).
Conclusion This study reveals distinct safety profiles for OCA and UDCA in
the treatment of PBC. OCA is associated with a higher frequency of pruritus,
fatigue, constipation, and increased blood alkaline phosphatase levels, while
UDCA is linked to hepatocellular carcinoma and type I hypersensitivity
reactions. These findings support personalized treatment approaches based on
individual patient characteristics.
Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development
Authors: Yosri Nermeen , Kamal Nurkhalida , Mediani Ahmed , AbouZid Sameh , Swillam Ahmed , Swilam Mahmoud , Ayyat Ahmed M. , Jantan Ibrahim 
Published: September 2024

Abstract
Viscum album has been employed traditionally to treat various ailments including as add-on therapy for cancer treatment. V. album formulations have been employed as adjuvants in cancer treatment due to their immunomodulatory activities as well as to alleviate the side effects of conventional cancer therapies. The present review provides updated information from the past 10 years on the immunomodulatory activity and inhibitory effects of V. album on cancer cells, its safety profile, and recent nanotechnology development. V. album extracts and their bioactive phytochemicals, particularly lectins, viscotoxins, and polyphenols, have demonstrated immunomodulatory activity and inhibitory effects against various types of cancer, with low cytotoxicity and side effects, in experimental studies and demonstrated promising anticancer activity in clinical studies in cancer patients. V. album extracts have been shown to enhance immune function by
promoting cytokine secretion and inducing both innate and adaptive immune responses, which can help improve immune surveillance against cancer cells. The development of V. album nanoparticles has boosted their biological activities, including inhibitory activity on cancer cells, and could possibly reduce undesired side effects of the plant. Further prospective studies on the plant as a source of new medicinal agents for use as an adjuvant in the treatment of cancer must be performed to provide sufficient efficacy and safety data.
A Comprehensive Multifunctional Approach for Measuring Parkinson's Disease Severity
Authors: Rahimi Morteza , Al Masry Zeina , Templeton John Michael , Schneider Sandra , Poellabauer Christian 
Published: September 2024

Abstract
Objectives This research study aims to advance the staging of Parkinson's disease (PD) by incorporating machine learning to assess and include a broader multifunctional spectrum of neurocognitive symptoms in the staging schemes beyond motor-centric assessments. Specifically, we provide a novel framework to modernize and personalize PD staging more objectively by proposing a hybrid feature scoring approach.
Methods We recruited 37 individuals diagnosed with PD, each of whom completed a series of tablet-based neurocognitive tests assessing motor, memory, speech, executive functions, and tasks ranging in complexity from single to multifunctional. Then, the collected data were used to develop a hybrid feature scoring system to calculate a weighted vector for each function. We evaluated the current PD staging schemes and developed a new approach based on the features selected and extracted using random forest and principal component analysis.
Results Our findings indicate a substantial bias in current PD staging systems toward fine motor skills, that is, other neurological functions (memory, speech, executive function, etc.) do not map into current PD stages as well as fine motor skills do. The results demonstrate that a more accurate and personalized assessment of PD severity could be achieved by including a more exhaustive range of neurocognitive functions in the staging systems either by involving multiple functions in a unified staging score or by designing a function-specific staging system.
Conclusion The proposed hybrid feature score approach provides a comprehensive understanding of PD by highlighting the need for a staging system that covers various neurocognitive functions. This approach could potentially lead to more effective, objective, and personalized treatment strategies. Further, this proposed methodology could be adapted to other neurodegenerative conditions such as Alzheimer's disease or amyotrophic lateral sclerosis.
Effectiveness and safety of a new clip for delivery using a duodenoscope for bleeding after endoscopic sphincterotomy
Authors: Yamaguchi Atsushi , Kamada Hiroki , Semba Shigeaki , Kato Naohiro , Okuda Yasuhiro , Teraoka Yuji , Mizumoto Takeshi , Tamaru Yuzuru , Hatakeyama Tsuyoshi , Kouno Hirotaka , Yoshida Shigeto 
Published: September 2024

Abstract
Background and study aims Hemostasis for post-endoscopic sphincterotomy (post-EST) bleeding involves no standard strategy. New clips designed for delivery using the duodenoscope (SureClip, Micro-Tech, Nanjing, China) have been utilized for gastrointestinal bleeding hemostasis and bleeding prevention after polypectomy and papillectomy. We retrospectively analyzed the effectiveness and safety of SureClip for post-EST bleeding.
Patients and methods Of 608 patients with endoscopic sphincterotomy (EST), 41 cases (6.7%) experienced post-EST bleeding from 2019 to 2023. Of these patients, 24 underwent hemostasis by SureClip, and the success rate of complete hemostasis and complication by hemostasis by SureClip was analyzed.
Results In 12 and 12 patients with urgent and delayed bleeding, 11 (91.7%) and 11 (91.7%) had successful hemostasis, respectively. In addition, missed patients achieved complete hemostasis with additional transcatheter arterial embolization and balloon compression, respectively. No complications were observed, including perforation, pancreatitis, and clipping bile duct and pancreatic duct by mistake.
Conclusions Hemostasis with SureClip is safe, effective, and not expensive for post-EST bleeding. It could be the first choice for hemostasis in patients with post-EST bleeding refractory to balloon compression.
The impact of NOCs in Chinese foreign policy: the cases of Angola and Sudan
Authors: Behrndt-Eriksen T. Kasandra 
Published: September 2024

AbstractChinese companies have invested substantially in countries abroad in recent years, including countries in Africa. This article investigates the activities of Chinese energy companies in Africa, looking at the cases of Angola and Sudan. It develops a theoretical framework that can examine the role of non-state actors in foreign policy. The article presents evidence that non-state actors play a role for Chinese foreign policy and sometimes go against the policy line from Beijing. Theoretically, it illuminates the increasing role played by national oil companies (NOCs) in foreign policy and contributes with explicitation of the role played by NOCs for the foreign policy of the state. The article also contributes with insights regarding the importance of concerns with domestic stability (weiwen) to Chinese foreign policy and how this motive relates to the Chinese NOC activities in a number of countries.
Stochastic Schrödinger equation for hot-carrier dynamics in plasmonic systems
Authors: Dall’Osto Giulia , Vanzan Mirko , Corni Stefano , Marsili Margherita , Coccia Emanuele 
Published: September 2024

We present a multiscale method coupling the theory of open quantum systems with real-time ab initio treatment of electronic structure to study hot-carrier dynamics in photoexcited plasmonic systems. We combine the Markovian Stochastic Schrödinger equation with an ab initio GW coupled to the Bethe–Salpeter (BSE) equation description of the electronic degrees of freedom, interacting with a metallic nanoparticle modeled classically according to the polarizable continuum model. We apply this methodology to study the effect of relaxation (T1) and pure dephasing (T2) times on the hot-carrier dynamics in a system composed of a quantum portion described at GW/BSE level, i.e., a CHO fragment adsorbed on a vertex of a rhodium nanocube, and of the rest of the nanocube, treated classically, when irradiated with a 2.7 eV light pulse, inspired by the experimental results on plasmon-driven CO2 photoreduction. A net hole injection from rhodium to CHO is observed, with and without the classical portion of the nanocube. The nanocube effect is to enhance the generated charge population by two orders of magnitude. The nonradiative decay, via a relaxation time T1 based on the energy-gap law, produces a rapid decrease of the charge population. Results with T2 only show that a charge injection retarded with respect to the pulse, which is present in the coherent dynamics, disappears when coherence is erased.
Fragment quantum embedding using the Householder transformation: A multi-state extension based on ensembles
Authors: Cernatic Filip , Fromager Emmanuel , Yalouz Saad 
Published: September 2024

In recent studies by Yalouz et al. [J. Chem. Phys. 157, 214112 (2022)] and Sekaran et al. [Phys. Rev. B 104, 035121 (2021) and Computation 10, 45 (2022)], density matrix embedding theory (DMET) has been reformulated through the use of the Householder transformation as a novel tool to embed a fragment within extended systems. The transformation was applied to a reference non-interacting one-electron reduced density matrix to construct fragments’ bath orbitals, which are crucial for subsequent ground state calculations. In the present work, we expand upon these previous developments and extend the utilization of the Householder transformation to the description of multiple electronic states, including ground and excited states. Based on an ensemble noninteracting density matrix, we demonstrate the feasibility of achieving exact fragment embedding through successive Householder transformations, resulting in a larger set of bath orbitals. We analytically prove that the number of additional bath orbitals scales directly with the number of fractionally occupied natural orbitals in the reference ensemble density matrix. A connection with the regular DMET bath construction is also made. Then, we illustrate the use of this ensemble embedding tool in single-shot DMET calculations to describe both ground and first excited states in a Hubbard lattice model and an ab initio hydrogen system. Finally, we discuss avenues for enhancing ensemble embedding through self-consistency and explore potential future directions.