bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the impact of botanical origin and harvesting period on carbon stable isotope ratio values (13C/12C) and different parameter analysis of Greek unifloral honeys: A chemometric approach for correct botanical discrimination
Authors: Karabagias Ioannis K. , Casiello Grazia , Kontakos Stavros , Louppis Artemis P. , Longobardi Francesco , Kontominas Michael G. 
Published: October 2016

SummaryThe aim of this study was to investigate the impact of botanical origin and harvesting period on carbon stable isotope ratio (13C/12C), colour intensity (CI), radical scavenging activity (%RSA), P and Sn content of Greek unifloral honeys. Thus, twenty‐four honey samples were collected during harvesting periods 2011–2012 and 2012–2013, from four different regions in Greece. 13C/12C ratios and minerals were determined using isotope ratio mass spectrometry (IRMS) and inductively coupled plasma optical–emission spectroscopy (ICP‐OES), respectively. CI and %RSA were measured using spectrophotometric assays. Results showed that only 13C/12C values and %RSA were affected by both botanical origin and harvesting period (P < 0.05). Applying then chemometric analyses to the collected data set, honeys were correctly classified according to honey type (correct classification rate 87.5% and 79.2% using the original and cross‐validation method, respectively). The use of different origin parameters has the potential to aid in honey authentication.
Impact of UVA on pruritus during UVA/B phototherapy of inflammatory skin diseases: a randomized double‐blind study
Authors: Maul J.‐T. , Kretschmer L. , Anzengruber F. , Pink A. , Murer C. , French L.E. , Hofbauer G.F. , Navarini A.A. 
Published: October 2016

AbstractBackgroundNarrowband (TL‐01) UVB phototherapy (UVB nb) is effective in treating inflammatory skin disease. The addition of UVA is traditionally advocated to reduce pruritus, but lacks evidence for this recommendation.ObjectivesThe aim of this study was to assess the effect of UVB nb and UVA phototherapy in combination compared against UVB nb monotherapy on pruritus, disease activity and quality of life.MethodsIn this double‐blind randomized clinical trial, 53 patients suffering from inflammatory skin diseases with pronounced itching (Visual Analogue Scale (VAS) for pruritus ≥5) were randomized into two treatment groups. One group received UVB nb (311 nm) phototherapy alone and another group received a combination of UVB nb and UVA (320–400 nm) phototherapy. UV therapy was performed three times per week over 16 weeks. Pruritus (VAS and 5‐D itch score), disease activity and quality of life (Dermatology Life Quality Index, DLQI) were assessed at baseline and weeks 4, 8, 12 and 16.ResultsIn both treatment groups, there was a reduction in pruritus scores, disease activity and DLQI. No difference in pruritus score, disease activity and quality of life could be detected between the group receiving UVB nb alone and those receiving UVB nb combined with UVA.ConclusionsPhototherapy with UVB nb alone, and UVB nb combined with UVA are equally effective in treating inflammatory skin disease and indifferent in reducing disease‐associated pruritus. Given this non‐inferiority for UVB nb monotherapy, the recommendation of adding UVA to UVB nb phototherapy for pruritic inflammatory skin disease should be abandoned.
Effects of Additional Acid Etching on the Dentin Bond Strengths of One‐Step Self‐Etch Adhesives Applied to Primary Teeth
Authors: Kim Yuhyun , Kim Shin , Jeong Taesung , Son Sung‐Ae , Kim Jiyeon 
Published: October 2016

AbstractObjectivesThe aim of this study was to evaluate the bond strengths of one‐step self‐etch adhesives applied to primary tooth dentin with and without additional acid etching.Materials and MethodsIn total, 154 specimens were prepared using 50 naturally exfoliated primary molars. Four commercial one‐step self‐etch adhesives were used in this study: Scotchbond™ Universal, All‐Bond Universal™, Adper™ Prompt™ L‐Pop™, and Clearfil S3 Bond™. Two etch‐and‐rinse adhesives, Prime & Bond® NT™ and Scotchbond™ Multi‐Purpose, served as controls. Microtensile bond strength tests were performed for specimens treated with the one‐step self‐etch adhesives with and without additional acid etching and those treated with the two etch‐and‐rinse adhesives.ResultsAll one‐step self‐etch adhesives except Adper Prompt L‐Pop exhibited increased microtensile bond strength values (p < 0.05) with additional acid etching. A nonsignificant interaction was observed between the type of self‐etch adhesive and additional acid etching (p = 0.056). Bond strength comparisons between the self‐etch adhesives used without additional acid etching and the etch‐and‐rinse adhesives revealed significantly higher values for Prime & Bond NT than for All‐Bond Universal® (p < 0.05). However, there were no significant differences between any etch‐and‐rinse adhesive and self‐etch adhesive used with additional acid etching, although Clearfil S3 Bond showed greater strength than Adper Prompt L‐Pop.ConclusionsOur results suggest that additional acid etching increases the bond strength of most one‐step self‐etch adhesives applied to primary tooth dentin.Clinical SignificanceAdditional acid etching of enamel and dentin can be recommended to increase the bond strength of one‐step self‐etch adhesives applied to primary teeth. (J Esthet Restor Dent 29:110–117, 2017)
Budesonide foam for mild to moderate distal ulcerative colitis: A systematic review and meta‐analysis
Authors: Zeng Jian , Lv Lin , Mei Zhe‐Chuan 
Published: October 2016

AbstractBackground and AimBudesonide is a second‐generation steroid with prominent topical effects and minimal systemic activity for patients with ulcerative colitis (UC). We perform a systematic review and meta‐analysis of randomized placebo‐controlled trials to assess the efficacy and safety of budesonide foam in mild‐to‐moderate distal UC.MethodsComprehensive searches were performed to identify all eligible studies. Outcome measures were clinical remission, endoscopic improvement, elimination of rectal bleeding, and adverse events. The risk ratio (RR) with 95% confidence interval (CI) was estimated for each outcome. All statistical analyses were performed in STATA 12.0.ResultsThree randomized placebo‐controlled trials recruiting 711 patients with mild‐to‐moderate distal UC were included in this study. No significant bias and heterogeneity was identified. Pooled analyses showed that budesonide foam was significantly superior to placebo for induction of clinical remission (RR = 1.83, 95%CI: 1.41, 2.37; P < 0.001) and endoscopic improvement (RR = 1.44, 95%CI: 1.23, 1.68; P < 0.001), and eliminating rectal bleeding at week 2 (RR = 2.00, 95%CI: 1.50, 2.66; P < 0.001), week 4 (RR = 1.73, 95%CI: 1.42, 2.12; P < 0.001), and week 6 (RR = 1.76, 95%CI: 1.45, 2.14; P < 0.001). No statistically significant difference was observed in the incidence of treatment‐related adverse events and therapeutic discontinuation because of adverse events between budesonide foam and placebo.ConclusionsBudesonide foam is well tolerated and superior to placebo in inducing clinical remission and endoscopic improvement, and eliminating rectal bleeding for mild‐to‐moderate distal UC.
ALBI and PALBI grade predict survival for HCC across treatment modalities and BCLC stages in the MELD Era
Authors: Liu Po‐Hong , Hsu Chia‐Yang , Hsia Cheng‐Yuan , Lee Yun‐Hsuan , Chiou Yi‐You , Huang Yi‐Hsiang , Lee Fa‐Yauh , Lin Han‐Chieh , Hou Ming‐Chih , Huo Teh‐Ia 
Published: October 2016

AbstractBackground and AimThe severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child–Turcotte–Pugh (CTP) classification or model for end‐stage liver disease (MELD) score. We aim to investigate the performance of albumin‐bilirubin (ALBI) and platelet‐albumin‐bilirubin (PALBI) grade, which are recently reported to be simple and objective measurements for liver reserve in HCC.MethodsBetween 2002 and 2014, consecutive 3182 HCC patients were enrolled to follow up their survival. The area under receiver‐operator‐characteristic curve (AUC) was calculated to test the discriminatory powers over 1‐year, 3‐year, and 5‐year survival.ResultsSignificant survival differences were found across all ALBI and PALBI grades (both P < 0.001). The majority (73%) of patients were CTP class A. Within CTP class A, ALBI revealed two prognostic groups while PALBI segregated three prognostic groups. The PABLI grade also identified three different survival groups for patients undergoing resection, ablation, and chemoembolization. Both ALBI and PALBI grade were capable of discerning survival among different HCC stages. The PALBI grade had significantly higher AUC compared with CTP classification and ALBI grade at 1, 3, and 5 years. For CTP class A patients, the PALBI grade was also associated with significantly higher AUC compared with ALBI grade at 1‐year and 3‐year intervals. The MELD score has the lowest AUC compared with other systems.ConclusionsBoth ALBI and PALBI grade are adequate models to assess liver dysfunction in HCC. The PALBI grade is consistently better in all patients, in patients with minimally decreased liver function, and in patients receiving different aggressive therapies.
Effect of Geriatric‐Specific Trauma Triage Criteria on Outcomes in Injured Older Adults: A Statewide Retrospective Cohort Study
Authors: Caterino Jeffrey M. , Brown Nicole V. , Hamilton Maya W. , Ichwan Brian , Khaliqdina Salman , Evans David C. , Darbha Subrahmanyan , Panchal Ashish R. , Shah Manish N. 
Published: October 2016

ObjectivesTo evaluate the effect on outcomes of the Ohio Department of Public Safety statewide geriatric triage criteria, established in 2009 for emergency medical services (EMS) to use for injured individuals aged 70 and older.DesignRetrospective cohort study of the Ohio Trauma Registry.SettingAll hospitals in Ohio.ParticipantsIndividuals aged 70 and older in the Ohio Trauma Registry from January 2006 through December 2011, 3 years before and 3 years after criteria adoption (N = 34,499).MeasurementsPrimary outcomes were in‐hospital mortality and discharge to home. Criteria effects were assessed using chi‐square tests, multivariable logistic regression, interrupted time series plots, and multivariable segmented regression models.ResultsAfter geriatric criteria were adopted, the proportion of older adults qualifying for trauma center transport increased from 44% to 58%, but EMS transport rates did not change (44% vs 45%). There was no difference in unadjusted mortality (7.1% vs 6.6%) (P = .10). In adjusted analyses, subjects with an injury severity score (ISS) less than 10 had lower mortality after adoption (3.0% vs 2.5%) (odds ratio (OR) = 0.81, 95% confidence interval (CI) = 0.70–0.95, P = .01). Discharge to home increased after adoption in the adjusted analysis (OR = 1.06, 95% CI = 1.01–1.11, P = .02). There were no time‐dependent changes for either outcome.ConclusionAlthough the proportion of older adults meeting criteria for trauma center transport substantially increased with geriatric triage criteria, there were no increases in trauma center transports. Adoption of statewide geriatric triage guidelines did not decrease mortality in more severely injured older adults but was associated with slightly lower mortality in individuals with mild injuries (ISS <10) and with more individuals discharged to home. Improving outcomes in injured older adults will require further attention to implementation and use of geriatric‐specific criteria.
Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study
Authors: Jepson R. E. , Warren H. R. , Syme H. M. , Elliott J. , Munroe P. B. 
Published: October 2016

ObjectivesIn humans, genome‐wide association studies have identified variants in the uromodulin gene (UMOD) associated with blood pressure and renal function. This study aimed to evaluate the association of single nucleotide polymorphisms at theUMODlocus with renal function and blood pressure in cats.MethodsWe retrospectively identified cats aged 14 years that had participated in a geriatric monitoring program, and from which stored DNA samples were available, from a computerised database. We then measured the association of specific single nucleotide polymorphisms in the felineUMODgene with renal function and systolic blood pressure as continuous variables and, also, the dichotomous outcome of azotaemic chronic kidney disease and systemic hypertension.ResultsEight intronic single nucleotide polymorphisms, one 1372 base pairs upstream from UMOD and two exonic single nucleotide polymorphisms were evaluated in 227 cats with renal and blood pressure data. An analysis of 188 cats found four single nucleotide polymorphisms to be significantly associated (P<0·01) with systolic blood pressure although all were in linkage disequilibrium. No significant associations were identified between single nucleotide polymorphisms and renal function or chronic kidney disease.Clinical SignificanceResults of this pilot study suggest that genetic variation inUMODmight influence blood pressure in cats, similar to findings in humans. Validation of these results is required.
Time course of hepatitis E‐specific antibodies in adults
Authors: Schemmerer M. , Rauh C. , Jilg W. , Wenzel J. J. 
Published: October 2016

SummaryHepatitis E virus (HEV) is highly endemic in industrialized countries, but there is a lack of knowledge on individual and overall antibody concentration dynamics. The aim of this study was to characterize longitudinal concentration changes of anti‐HEV immunoglobulin G (anti‐HEV IgG) by enzyme immunoassay (EIA). In total, 199 serum samples collected from 45 subjects over 18 years were analysed. A wide range of anti‐HEV IgG levels was found. Overall, anti‐HEV IgG significantly decreased after an observation period of at least 5 years. One negative seroconversion was observed. Four individual profiles suggested single and even multiple HEV reinfections despite pre‐existing HEV antibodies.
Transient elastography for the diagnosis of liver fibrosis: a systematic review of economic evaluations
Authors: van Katwyk Sasha , Coyle Doug , Cooper Curtis , Pussegoda Kusala , Cameron Chris , Skidmore Becky , Brener Stacey , Moher David , Thavorn Kednapa 
Published: October 2016

AbstractBackgroundLiver biopsy remains the gold standard for the diagnosis of liver fibrosis, but its use as a diagnostic tool is limited by its invasive nature and high cost.ObjectiveThe aim of this study was to systematically review the cost‐effectiveness of transient elastography (TE) with and without controlled attenuation parameter (CAP) for the diagnosis of liver fibrosis or steatosis in patients with hepatitis B, hepatitis C, alcoholic liver disease and non‐alcoholic fatty liver disease.MethodsAn economic literature search was performed. Eligibility criteria included systematic reviews, health technology assessments or economic evaluations ofTEcompared to liver biopsy and other non‐invasive tests. After abstract screening, full‐text reports of potentially relevant articles were assessed in duplicate. The methodological quality of the included studies was also appraised.ResultsThe database search yielded 253 records; four cost‐effectiveness and four cost‐utility studies were included. The methodological quality of the included studies varies. High‐quality cost‐effectiveness studies not only suggested thatTEis less costly but also less accurate than liver biopsy. The incremental cost‐effectiveness ratio (ICER) ofTEimproves with a greater level of diagnostic accuracy and a higher degree of liver fibrosis. High‐quality cost‐utility studies indicated thatTEis a cost‐effective alternative to biopsy withICERbetween $9000 and $14 000 perQALYfor patients with hepatitis C. We did not find studies that assessed the cost‐effectiveness ofTEwithCAPfor the diagnosis of liver steatosis.ConclusionsTransient elastography is an economically attractive alternative to liver biopsy and other non‐invasive diagnostic tests especially for patients with a higher degree of liver fibrosis.
The fate of moderately volatile elements in impact events—Lithium connection between the Ries sediments and central European tektites
Authors: Rodovská Zuzana , Magna Tomáš , Žák Karel , Skála Roman , Brachaniec Tomasz , Visscher Channon 
Published: October 2016

AbstractLithium abundances and isotope compositions are presented for a suite of sediments from the surroundings of the Ries Impact structure, paralleled by new Li data for central European tektites (moldavites) from several substrewn fields (South Bohemia, Moravia, Cheb Basin, Lusatia), including a specimen from the newly discovered substrewn field in Poland. The data set was supplemented by three clay fractions isolated from sedimentary samples. Moldavites measured in this study show a very narrow range in δ7Li values (−0.6 to 0.3‰ relative to L‐SVEC) and Li contents (23.9–48.1 ppm). This contrasts with sediments from the Ries area which show remarkable range in Li isotope compositions (from −6.9 to 13.4‰) and Li contents (0.6–256 ppm). The OSM sediments which, based on chemical similarity, formed the major part of moldavites, show a range in δ7Li values from −2.0 to 7.9‰ and Li contents from 5.8 to 78.9 ppm. Therefore, the formation of moldavites was apparently accompanied by large‐scale mixing, paralleled by chemical and isotope homogenization of their parent matter. The proposed Li mixing model indicates that sands, clayey sediments, and low volumes of carbonates are the major components for tektite formation whereas residual paleokarst sediments could have been a minor but important component for a subset of moldavites. Striking homogenization of Li in tektites, combined with limited Li loss during impacts, may suggest that moderately volatile elements are not scavenged and isotopically fractionated during large‐scale collisions, which is consistent with recent models. In general, whether homogenization of bodies with distinct Li isotope systematics takes place, or collision of bodies with similar Li systematics operates cannot be resolved at present stage but Li isotope homogeneity of solar system planets and asteroidal bodies tentatively implies the latter.
Multilocus approaches for the measurement of selection on correlated genetic loci
Authors: Gompert Zachariah , Egan Scott P. , Barrett Rowan D. H. , Feder Jeffrey L. , Nosil Patrik 
Published: October 2016

AbstractThe study of ecological speciation is inherently linked to the study of selection. Methods for estimating phenotypic selection within a generation based on associations between trait values and fitness (e.g. survival) of individuals are established. These methods attempt to disentangle selection acting directly on a trait from indirect selection caused by correlations with other traits via multivariate statistical approaches (i.e. inference of selection gradients). The estimation of selection on genotypic or genomic variation could also benefit from disentangling direct and indirect selection on genetic loci. However, achieving this goal is difficult with genomic data because the number of potentially correlated genetic loci (p) is very large relative to the number of individuals sampled (n). In other words, the number of model parameters exceeds the number of observations (p ≫ n). We present simulations examining the utility of whole‐genome regression approaches (i.e. Bayesian sparse linear mixed models) for quantifying direct selection in cases where p ≫ n. Such models have been used for genome‐wide association mapping and are common in artificial breeding. Our results show they hold promise for studies of natural selection in the wild and thus of ecological speciation. But we also demonstrate important limitations to the approach and discuss study designs required for more robust inferences.
The Dialogue of Faith and Cultures: From Paul VI to Benedict XVI
Authors: Phillips Peter 
Published: October 2016

AbstractVatican II's documents Gaudium et Spes and Ad gentes reveal two interrelated dialogues: a dialogue between Church and other religious traditions, and a more general dialogue between faith and particular societies. The theme takes its cue form Paul VI's first encyclical, Ecclesiam Suam (1964) and, in the last fifty years, has flowered into a rich body of teaching expressed in various documents. It became central to the teaching of John Paul II with his passionate concern for the dignity of the human person. Benedict XVI in a series of speeches delivered both before and after becoming Pope introduced a note of caution to such cultural dialogue. While accepting that he offered an impressive case against the positivism, which he considered to be undermining contemporary culture, we should be hesitant in following his more cautious approach.
Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia
Authors: Nakajima N. , Sato H. , Takahashi K. , Hasegawa G. , Mizuno K. , Hashimoto S. , Sato Y. , Terai S. 
Published: October 2016

AbstractBackgroundHistopathology of muscularis externa in primary esophageal motility disorders has been characterized previously. We aimed to correlate the results of high‐resolution manometry with those of histopathology.MethodsDuring peroral endoscopic myotomy, peroral esophageal muscle biopsy was performed in patients with primary esophageal motility disorders. Immunohistochemical staining for c‐kit was performed to assess the interstitial cells of Cajal (ICCs). Hematoxylin Eosin and Azan‐Mallory staining were used to detect muscle atrophy, inflammation, and fibrosis, respectively.Key ResultsSlides from 30 patients with the following motility disorders were analyzed: achalasia (type I: 14, type II: 5, type III: 3), one diffuse esophageal spasm (DES), two outflow obstruction (OO), four jackhammer esophagus (JE), and one nutcracker esophagus (NE). ICCs were preserved in high numbers in type III achalasia (n=9.4±1.2 cells/high power field [HPF]), compared to types I (n=3.7±0.3 cells/HPF) and II (n=3.5±1.0 cells/HPF). Moreover, severe fibrosis was only observed in type I achalasia and not in other types of achalasia, OO, or DES. Four of five patients with JE and NE had severe inflammation with eosinophilic infiltration of the esophageal muscle layer (73.8±50.3 eosinophils/HPF) with no epithelial eosinophils. One patient with JE showed a visceral myopathy pattern.Conclusions & InferencesCompared to types I and II, type III achalasia showed preserved ICCs, with variable data regarding DES and OO. In disorders considered as primary esophageal motility disorders, a disease category exists, which shows eosinophilic infiltration in the esophageal muscle layer with no eosinophils in the epithelium.