bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the relevance ofsmall nations. Religion and politics in S.N. Eisenstadt's multiple modernities paradigm
Authors: Laniel Jean‐François 
Published: October 2017

AbstractIn recent years, the paradigm of multiple modernities has spurred a growing interest in theoretical, empirical and comparative studies. Among these, the relationships between religious traditions and social dynamics have received particular attention. Counter to evolutionary accounts of modernisation processes, Eisenstadt studied the persisting and evolving links between religion, politics and modernity in different national and civilisational settings. Indeed, the collective incidence of culture, of religion and of tradition was placed at the very heart of Eisenstadt's thought – hence the many ‘cultural programs of modernity'. It is the originality of this understanding of societiesinmodernity that we wish to underline and help explain by his interest for small nations and the religio‐political. I first advocate Eisenstadt's version of multiple modernities, highlighting the paradigm's specific knowledge interest. Secondly, we turn our attention to the often ignored importance of ‘Jewish civilisation' in Eisenstadt's thought. In so doing, we underline Israel's ‘smallness' and its characteristics as a ‘small nation'. Lastly, we stress the elective affinity between multiple modernities and small nations in the study of politics and religion. As is the case for small nations, religion constitutes the ‘other half of modernity', too rarely genuinely considered in (large nation) modernists' accounts.
Correlation of Noncancer Benchmark Doses in Short‐ and Long‐Term Rodent Bioassays
Authors: Kratchman Jessica , Wang Bing , Fox John , Gray George 
Published: October 2017

AbstractThis study investigated whether, in the absence of chronic noncancer toxicity data, short‐term noncancer toxicity data can be used to predict chronic toxicity effect levels by focusing on the dose–response relationship instead of a critical effect. Data from National Toxicology Program (NTP) technical reports have been extracted and modeled using the Environmental Protection Agency's Benchmark Dose Software. Best‐fit, minimum benchmark dose (BMD), and benchmark dose lower limits (BMDLs) have been modeled for all NTP pathologist identified significant nonneoplastic lesions, final mean body weight, and mean organ weight of 41 chemicals tested by NTP between 2000 and 2012. Models were then developed at the chemical level using orthogonal regression techniques to predict chronic (two years) noncancer health effect levels using the results of the short‐term (three months) toxicity data. The findings indicate that short‐term animal studies may reasonably provide a quantitative estimate of a chronic BMD or BMDL. This can allow for faster development of human health toxicity values for risk assessment for chemicals that lack chronic toxicity data.
Using a Web‐Based Diary Method to Estimate Risks and Benefits from Fish Consumption
Authors: Connelly Nancy A. , Lauber T. Bruce , Niederdeppe Jeff , Knuth Barbara A. 
Published: October 2017

AbstractAccurate estimates of the amount and type of fish people eat are necessary to determine the health benefits and risks of consuming fish, and to assess compliance with fish consumption guidelines issued for fish affected by chemical contaminants. We developed a web‐based and mobile‐phone‐enabled diary methodology to collect detailed fish consumption information for two 16‐week periods in the summers of 2014 and 2015. We recruited study participants from two populations living in the Great Lakes region—women of childbearing age (WCBA) and urban residents who had purchased fishing licenses. In this article, we describe the methodology in detail and provide evidence related to participation rates, the representativeness of our sample over time, and both convergent validity and reliability of the data collection methods. Overall, 56% of WCBA and 50% of urban anglers provided complete data across both data collection periods. Among those who provided information at the beginning of Year 2, 97% of both audiences provided information throughout the entire 16‐week period. Those who participated throughout the two‐year period were slightly older on average (1.9–2.5 years) than other members of our original samples. We conclude that using diaries with web and smartphone technology, combined with incentives and persistent communication, has strong potential for assessing fish consumption in other areas of the country or for situations where the potential risks associated with fish consumption are substantial and the cost can be justified.
The relationship between skin function, barrier properties, and body‐dependent factors
Authors: Dąbrowska A.K. , Spano F. , Derler S. , Adlhart C. , Spencer N.D. , Rossi R.M. 
Published: October 2017

AbstractBackgroundSkin is a multilayer interface between the body and the environment, responsible for many important functions, such as temperature regulation, water transport, sensation, and protection from external triggers.ObjectivesThis paper provides an overview of principal factors that influence human skin and describes the diversity of skin characteristics, its causes and possible consequences. It also discusses limitations in the barrier function of the skin, describing mechanisms of absorption.MethodsThere are a number of in vivo investigations focusing on the diversity of human skin characteristics with reference to barrier properties and body‐dependent factors.ResultsSkin properties vary among individuals of different age, gender, ethnicity, and skin types. In addition, skin characteristics differ depending on the body site and can be influenced by the body‐mass index and lifestyle. Although one of the main functions of the skin is to act as a barrier, absorption of some substances remains possible.ConclusionsVarious factors can alter human skin properties, which can be reflected in skin function and the quality of everyday life. Skin properties and function are strongly interlinked.
Macro‐ and meso‐scale structural criteria for identifying pre‐thrusting normal faults within foreland fold‐and‐thrust belts: Insights from the Central‐Northern Apennines (Italy)
Authors: Calamita Fernando , Di Domenica Alessandra , Pace Paolo 
Published: October 2017

AbstractReliable macro‐ and meso‐scale structural criteria for identifying pre‐thrusting normal faults within inversion‐dominated foreland thrust belts are here reappraised by showing field cases from the Central‐Northern Apennines of Italy. Field‐based analyses of relative chronologies among the structures allow determination of the timing of pre‐thrusting normal faulting, the positive inversion of the faults and their post‐thrusting reactivation when absolute chronostratigraphic constraints are lacking. The correct identification of pre‐thrusting normal faults allows recognition of shortcut and reactivation anticlines, and these have important implications for the definition of the thrust‐belt structural style and for the estimation of post‐orogenic extension.
Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA‐E/human CD46 double‐transgenic pig limbs with human blood
Authors: Puga Yung Gisella , Bongoni Anjan K. , Pradier Amandine , Madelon Natacha , Papaserafeim Maria , Sfriso Riccardo , Ayares David L. , Wolf Eckhard , Klymiuk Nikolai , Bähr Andrea , Constantinescu Mihai A. , Voegelin Esther , Kiermeir David , Jenni Hansjörg , Rieben Robert , Seebach Jörg D. 
Published: October 2017

AbstractBackgroundIn pig‐to‐human xenotransplantation, interactions between human natural killer (NK) cells and porcine endothelial cells (pEC) are characterized by recruitment and cytotoxicity. Protection from xenogeneic NK cytotoxicity can be achieved in vitro by the expression of the non‐classical human leukocyte antigen‐E (HLA‐E) on pEC. Thus, the aim of this study was to analyze NK cell responses to vascularized xenografts using an ex vivo perfusion system of pig limbs with human blood.MethodsSix pig forelimbs per group, respectively, stemming from either wild‐type (wt) or HLA‐E/hCD46 double‐transgenic (tg) animals, were perfused ex vivo with heparinized human blood for 12 hours. Blood samples were collected at defined time intervals, cell numbers counted, and peripheral blood mononuclear cells analyzed for phenotype by flow cytometry. Muscle biopsies were analyzed for NK cell infiltration. In vitro NK cytotoxicity assays were performed using pEC derived from wt and tg animals as target cells.ResultsEx vivo, a strong reduction in circulating human CD45 leukocytes was observed after 60 minutes of xenoperfusion in both wt and tg limb groups. NK cell numbers dropped significantly. Within the first 10 minutes, the decrease in NK cells was more significant in the wt limb perfusions as compared to tg limbs. Immunohistology of biopsies taken after 12 hours showed less NK cell tissue infiltration in the tg limbs. In vitro, NK cytotoxicity against hCD46 single tg pEC and wt pEC was similar, while lysis of double tg HLA‐E/hCD46 pEC was significantly reduced. Finally, circulating cells of pig origin were observed during the ex vivo xenoperfusions. These cells expressed phenotypes mainly of monocytes, B and T lymphocytes, NK cells, as well as some activated endothelial cells.ConclusionsEx vivo perfusion of pig forelimbs using whole human blood represents a powerful tool to study humoral and early cell‐mediated rejection mechanisms of vascularized pig‐to‐human xenotransplantation, although there are several limitations of the model. Here, we show that (i) transgenic expression of HLA‐E/hCD46 in pig limbs provides partial protection from human NK cell‐mediated xeno responses and (ii) the emergence of a pig cell population during xenoperfusions with implications for the immunogenicity of xenografts.
IMPLEMENTATION METHOD ON MEDICAL IMAGE COMPRESSION SYSTEM: A REVIEW
Authors: Muharam Azlan , Ahmad Afandi 
Published: October 2017

The rapid development of medical imaging and the invention of various medicines have benefited mankind and the whole community. Medical image processing is a niche area concerned with the operations and processes of generating images of the human body for clinical purposes. Potential areas such as image acquisition, image enhancement, image compression and storage, and image based visualization also include in medical image processing analysis. Unfortunately, medical image compression dealing with three-dimensional (3-D) modalities still in the pre-matured stage. Along with that, very limited researchers take a challenge to apply hardware on their implementation. Referring to the previous work reviewed, most of the compression method used lossless rather than lossy. For implementation using software, MATLAB and Verilog are the famous candidates among researchers. In term of analysis, most of the previous works conducted objective test compared with subjective test. This paper thoroughly reviews the recent advances in medical image compression mainly in terms of types of compression, software and hardware implementations and performance evaluation. Furthermore, challenges and open research issues are discussed in order to provide perspectives for future potential research. In conclusion, the overall picture of the image processing landscape, where several researchers more focused on software implementations and various combinations of software and hardware implementation.
Cognitive bias modification for social anxiety in adults who stutter: a feasibility study of a randomised controlled trial
Authors: McAllister Jan , Gascoine Sally , Carroll Amy , Humby Kate , Kingston Mary , Shepstone Lee , Risebro Helen , Mackintosh Bundy , Thompson Tammy Davidson , Hodgekins Jo 
Published: October 2017

ObjectiveTo determine the feasibility and acceptability of a computerised treatment for social anxiety disorder for adults who stutter including identification of recruitment, retention and completion rates, large cost drivers and selection of most appropriate outcome measure(s) to inform the design of a future definitive trial.DesignTwo-group parallel design (treatment vs placebo), double-blinded feasibility study. Participants: 31 adults who stutter.InterventionAttention training via an online probe detection task in which the stimuli were images of faces displaying neutral and disgusted expressions.Main outcome measuresPsychological measures: Structured Clinical Interview Global Assessment of Functioning score; Liebowitz Social Anxiety Scale; Social Phobia and Anxiety Inventory; State-Trait Anxiety Inventory; Unhelpful Thoughts and Beliefs about Stuttering. Speech fluency: percent syllables stuttered. Economic evaluation: resource use questionnaire; EuroQol three-dimension questionnaire.Acceptability: Likert Scale questionnaire of experience of trial, acceptability of the intervention and randomisation procedure.ResultsFeasibility of recruitment strategy was demonstrated. Participant feedback indicated that the intervention and definitive trial, including randomisation, would be acceptable to adults who stutter. Of the 31 participants who were randomised, 25 provided data at all three data collection points.ConclusionsThe feasibility study informed components of the intervention. Modifications to the design are needed before a definitive trial can be undertaken.Trial registration numberI SRCTN55065978; Post-results.
What are the associations between neighbourhood walkability and sedentary time in New Zealand adults? The URBAN cross-sectional study
Authors: Hinckson Erica , Cerin Ester , Mavoa Surzanne , Smith Melody , Badland Hannah , Witten Karen , Kearns Robin , Schofield Grant 
Published: October 2017

ObjectivesWe estimated associations between objectively determined neighbourhood ‘walkability’ attributes and accelerometer-derived sedentary time (ST) by sex, city or type of day.DesignA cross-sectional study.SettingThe URBAN (Understanding the Relationship between Activity and Neighbourhoods) study was conducted in 48 neighbourhoods across four cities in New Zealand (August 2008 to October 2010).ParticipantsThe response rate was 41% (2029 recruited participants/5007 eligible households approached). In total, 1762 participants (aged 41.4±12.1, mean±SD) met the data inclusion criteria and were included in analyses.Primary and secondary outcome measuresThe exposure variables were geographical information system (GIS) measures of neighbourhood walkability (ie, street connectivity, residential density, land-use mix, retail footprint area ratio) for street network buffers of 500 m and 1000 m around residential addresses. Participants wore an accelerometer for 7 days. The outcome measure was average daily minutes of ST.ResultsData were available from 1762 participants (aged 41.4±12.1 years; 58% women). No significant main effects of GIS-based neighbourhood walkability measures were found with ST. Retail footprint area ratio was negatively associated with sedentary time in women, significant only for 500 m residential buffers. An increase of 1 decile in street connectivity was significantly associated with a decrease of over 5 min of ST per day in Christchurch residents for both residential buffers.ConclusionNeighbourhoods with proximal retail and higher street connectivity seem to be associated with less ST. These effects were sex and city specific.
Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study
Authors: Pedrotti Emilio , Demasi Christian Luigi , Bruni Enrico , Bosello Francesca , Di Sarro Paolo Plinio , Passilongo Mattia , Fasolo Adriano , Gennaro Nicola , De Gregorio Alessandra , Ferrari Marcello , Marchini Giorgio 
Published: October 2017

ObjectivesTo assess the occurrence of glaucoma, eyelid, corneal and macular disorders in a cohort of patients with obstructive sleep apnoea (OSA) diagnosed by overnight polysomnography and to investigate into the risk factors for the above eye diseases (EDs).DesignCross-sectional cohort study between 2014 and 2015.SettingUnit of Respiratory Medicine and Eye Clinic of the University of Verona.Participants431 consecutive patients were considered eligible. Of these, 87 declined to participate, 35 were untraceable and 13 were deceased.InterventionsA complete ophthalmic evaluation of both eyes for each patient.Primary and secondary outcome measuresBest-corrected distance visual acuity, intraocular pressure, corneal, macular and optic nerve optical coherence tomography, ocular aberrometry, optic nerve laser polarimetry, visual field test, and eyelid examination.Results296 patients aged 64.5±12.8 years, 23% female and 77% male, underwent ophthalmic examination. There was 56% (n=166) prevalence of eyelid disorders, 27% (n=80) of corneal disorders, 13% (n=39) of macular disorders and 11% (n=33) of glaucoma. Advancing age was not associated with the severity of OSA, while significant differences were found for gender, body mass index, Oxygen Desaturation Index, smoking habit, hypertension and diabetes. Severe OSA was significantly associated with glaucoma (OR, 95% CI 1.05 to 5.93, p=0.037).ConclusionsEDs were more prevalent in our patinets with OSA than in the general population. Severe Apnoea/Hypopnoea Index level seemed to play a role as risk factor only for glaucoma.
Comparison of regional with general anaesthesia on postoperative delirium (RAGA-delirium) in the older patients undergoing hip fracture surgery: study protocol for a multicentre randomised controlled trial
Authors: Li Ting , Yeung Joyce , Li Jun , Zhang Yan , Melody Teresa , Gao Ye , Wang Yi , Lian Qianquan , Gao Fang 
Published: October 2017

IntroductionPostoperative delirium (POD) is a common serious postoperative complication especially in older people and is associated with increased mortality, morbidity and healthcare costs. There is no clear consensus which anaesthesia is associated with less incidence of POD for older patients. We aim to assess whether regional anaesthesia results in lower incidence of POD comparing with general anaesthesia (GA) among older patients undergoing hip fracture surgery.Methods and analysisRAGA-delirium is a pragmatic, multicentre, prospective, parallel grouped, randomised controlled clinical trial comparing RA or GA for hip fracture surgery. A total of 1000 patients who are 65 years or over and who are having planned hip fracture surgery in nine clinical trial centres of China will be randomised in a 1:1 ratio to receive either anaesthesia for the surgery. The primary endpoint will be the incidence of POD at day 7. The secondary endpoints will be the subtype, severity and duration of delirium, postoperative acute pain score, incidence of other postoperative non-delirium complications, quality of life and cost-effective outcomes. Randomisation will be performed at the patient level using computer-generated assignment. Outcome assessors will be blinded from intervention assignment. Assessments will be conducted before surgery, intraoperatively, postoperatively, during the hospital stay, at 30-day, 6-month and 1-year postoperative intervals.Potential impact of studyThis study will provide clinical evidence with a more robust methodology to help anaesthetists in selecting appropriate anaesthesia for older patients with high risk for POD. At the era of increasing emphasis on delirium prevention, this trial has the potential to inform the future national guideline to reduce POD.Ethics and disseminationEthical approved by the local institutional review board. Trial results will be presented at national and international academic conferences, and published in peer-reviewed journals.Trial registration numberClinicalTrials.gov (NCT02213380); pre-results.
Impact of child summertime obesity interventions on body mass index, and weight-related behaviours: a systematic review and meta-analysis protocol
Authors: Moreno Jennette P , Vézina-Im Lydi-Anne , Vaughan Elizabeth M , Baranowski Tom 
Published: October 2017

IntroductionIn previous studies, it has been found that on average, children consistently gained weight during the summer months at an increased rate compared with the 9-month school year. This contributed to an increased prevalence of overweight and obesity in children. Several obesity-related interventions have occurred during or targeting the summer months. We propose to conduct a systematic review and meta-analysis of the impact of obesity prevention and treatment interventions for school-age children conducted during the summer or targeting the summer months when children are not in school on their body mass index (BMI), or weight-related behaviours.Methods and analysesA literature search will be conducted by the first author (JPM) using MEDLINE/PubMed, Cochrane Library, Scopus, CINAHL, PsycINFO, EMBASE and Proquest Dissertations and Theses databases from the date of inception to present. Studies must examine interventions that address the modification or promotion of weight-related behaviours (eg, dietary patterns, eating behaviours, physical activity (PA), sedentary behaviour or sleep) and target school-age children (ages 5–18). The primary outcomes will be changes from baseline to postintervention and/or the last available follow-up measurement in weight, BMI, BMI percentile, standardised BMI or per cent body fat. Secondary outcomes will include changes in dietary intake, PA, sedentary behaviour or sleep. Risk of bias will be assessed using the Cochrane risk of bias tool for randomised and non-randomised studies, as appropriate.Ethics and disseminationBecause this is a protocol for a systematic review, ethics approval will not be required. The findings will be disseminated via presentations at scientific conferences and published in a peer-reviewed journal. All amendments to the protocol will be documented and dated and reported in the PROSPERO trial registry.PROSPERO registration numberCRD42016041750
Secondary analysis of frequency, circumstances and consequences of calculation errors of the HEART (history, ECG, age, risk factors and troponin) score at the emergency departments of nine hospitals in the Netherlands
Authors: Ras Marten , Reitsma Johannes B , Hoes Arno W , Six Alfred Jacob , Poldervaart Judith M 
Published: October 2017

ObjectiveThe HEART score can accurately stratify the risk of major adverse cardiac events (MACE) in patients with chest pain. We investigated the frequency, circumstances and potential consequences of errors in its calculation.MethodsWe performed a secondary analysis of a stepped wedge trial of patients with chest pain presenting to nine Dutch emergency departments. We recalculated HEART scores for all patients by re-evaluating the elements age (A), risk factors (R) and troponin (T) and compared these new scores with those given by physicians in daily practice. We investigated which circumstances increased the probability of incorrect scoring and explored the potential consequences.ResultsThe HEART score was incorrectly scored in 266 out of 1752 patients (15.2%; 95% CI 13.5% to 16.9%). Most errors occurred in the R (‘Risk factors’) element (61%). Time of admission, and patient’s age or gender did not contribute to errors, but more errors were made in patients with higher scores. In 102 patients (5.8%, 95% CI 4.7% to 6.9%) the incorrect HEART score resulted in incorrect risk categorisation (too low or too high). Patients with an incorrectly calculated HEART score had a higher risk of MACE (OR 1.85; 95% CI 1.37 to 2.50), which was largely related to more errors being made in patients with higher HEART scores.ConclusionsOur results show that the HEART score was incorrectly calculated in 15% of patients, leading to inappropriate risk categorisation in 5.8% which may have led to suboptimal clinical decision-making and management. Actions should be taken to improve the score’s use in daily practice.