bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical correlation of CD4 count and dry eye disease (DED) severity among Human Immunodeficiency Virus (HIV) patients: A case study in Voluntary Counseling and Testing Clinic RSUP Prof Ngoerah, Bali
Authors: Wulansari Putu Ayu , Juliari I Gusti Ayu Made , Pramita Ida Ayu Ary 
Published: September 2024

Introduction: Dry eye disease (DED) is a condition affecting the surface of the eye and the stability of tears, influenced by various factors. It has been documented as one of the most common ocular issues in the front segment among individuals with HIV, typically appearing in the later stages of the disease. The study sought to examine the clinical relationship between CD4 count and the severity of the condition.
Method: This study was conducted as a cross-sectional analysis within a hospital setting, involving 75 HIV-positive patients (140 eyes) aged between 18 and 50 years. These patients were referred to the ophthalmology clinic in the Voluntary Counseling and Testing (VCT) center due to complaints related to ocular surface issues, and they were enrolled in the study. All patients underwent a thorough ophthalmological assessment, including the completion of a dry eye questionnaire, specifically the Ocular Surface Disease Index (OSDI), and measurement of tear film break-up time (TBUT).
Results: The research revealed a notable moderate positive correlation between CD4 count and TBUT (r=0.509; p=0.005), and a negative correlation with OSDI score (r=-0.252, p=0.035). Significant differences were observed in CD4 count between mild and moderate dry eyes (p=0.005) as well as between mild and severe dry eyes (p=0.005). No significant difference was found between moderate and severe dry eyes (p=0.435). The severity of dry eye in HIV patients appears to vary across different clinical stages of the disease, coinfection statuses, and treatment histories, although these differences did not reach statistical significance in the results.
Conclusion: A correlation exists between CD4 count and the severity of dry eye disease among HIV patients. HIV patients with lower CD4 counts are at a higher risk of developing severe dry eye disease.
Tuberkulosis paru pengobatan gagal pada kasus dewasa: laporan kasus
Authors: Krisnanda Made Yogi , Sriandari Luh Putu Feby , Darmayanti Sheila Gerhana 
Published: September 2024

Background: Based on World Health Organization data, Indonesia is ranked second in terms of TB cases in the world. The health-related problem of Tuberculosis (TB) is also increasing, with Indonesia contributing 9.2 percent of the world's total population of TB cases. The number of cases of treatment failure of pulmonary TB at the Seririt I Community Health Center was 12.5%. TB treatment failure is a patient whose sputum examination results remain positive or return positive in the fifth month or more during the treatment period. The aim of this study is to explain about TB treatment failure in adult patient.
Case Description: We report a 34-year-old male patient with a case of pulmonary TB who has treatment failure at the Seririt I Community Health Center. The patient was diagnosed as treatment failure through a sputum examination in the 5th month, which showed that the sputum contained acid-fast bacteria, namely M. tuberculosis, and was confirmed by repeated Rapid Molecular Tests (TCM) and plain chest x-ray with negative results. The patient was treated by repeating category 1 anti-TB treatment with the 2HRZE/4HR regimen for six months.
Conclusion: TB treatment failure is caused by several risk factors. The risk factors that appear in this patient are indicated by the presence of cavities that appear in this patient.

Latar Belakang: Berdasarkan data WHO, Indonesia menempati peringkat kedua dalam kasus tuberkulosis (TB) terbanyak di dunia. Masalah kesehatan TB juga meningkat dengan Indonesia sebagai penyumbang 9,2% dari populasi total kasus TB dunia. Angka kasus TB paru gagal pengobatan pada Puskesmas Seririt I adalah 12,5%. TB gagal pengobatan merupakan pasien yang hasil pemeriksaan dahaknya tetap positif atau kembali menjadi positif pada bulan kelima atau lebih selama masa pengobatan. Laporan kasus ini bertujuan untuk memaparkan kasus TB paru pengobatan gagal pada kasus dewasa.
Deskripsi Kasus: Kami melaporkan seorang pasien laki-laki 34 tahun dengan kasus TB paru gagal pengobatan di Puskesmas Seririt I. Pasien terdiagnosis gagal pengobatan melalui pemeriksaan dahak pada bulan ke-5 yang menunjukan pada dahak terdapat bakteri taham asam yaitu M. tuberculosis dan dikonfirmasi dengan Tes Cepat Molekuler (TCM) ulang pada dan foto polos dada dengan hasil negatif. Pasien ditatalaksana dengan mengulangi pengobatan obat anti TB (OAT) kategori 1 dengan regimen 2HRZE/4HR selama enam bulan.
Kesimpulan: TB gagal pengobatan disebabkan oleh beberapa faktor resiko. Faktor resiko yang muncul pada pasien ini ditunjukan dengan adanya kavitas yang muncul pada pasien ini.
HASIL BELAJAR TEMATIK PESERTA DIDIK KELAS IV SEKOLAH DASAR DALAM PEMBELAJARAN MODEL KOOPERATIF TIPE JIGSAW
Authors: Agasi Diren , Maulani Yulia , Fitria Yanti 
Published: September 2024

Kegiatan penelitian ini bertujuan guna melihat benar atau tidaknya penerapan model cooperative learning tipe jigsaw memberikan dampak yang signifikan kepada peningkatan hasil belajar peserta didik dalam pembelajaran tematik pada kelas IV di Sekolah Dasar (SD), teknik atau metode pada penelitian ini yaitu metode quasy eksperimental design. Kegiatan penelitian akan dilaksanakan di lingkup sekolah dasar sekenagarian Sialang yang berjumlah enam sekolah yaitu Sekolah Dasar A, Sekolah Dasar B, Sekolah Dasar C, Sekolah Dasar D, Sekolah Dasar E dan Sekolah Dasar F pada tanggal 12- 26 Oktober 2021. Untuk memperoleh sampel dalam penelitian ini peneliti menggunakan teknik pusposive sampling dan dikombinasikan dengan simple random sampling untuk menentukan kelompok eksperimen dengan kelompok kontrol. Selanjutnya, menentukan mana SD yang menjadi group atau kelompok eksperimen serta kontrol dengan memakai teknik simple random sampling. berdasarkan data yang diperoleh posttest untuk kelompok ekperimen dan kontrol untuk uji t maka diperoleh nilai t-hitung sebesar 4,12 2,060 untuk nilai t-tabel. Sehingga dari persamaan berikut dapat dinyatakan Ha diterima atau hipotesis penelitian diterima, yang berarti terdapat pengaruh yang signifikan penggunaan model cooperative learning tipe jigsaw terhadap hasil belajar tematik peserta didik kelas IV SD pada sampel penelitian ini..
Variation among Blackgram (Vigna mungo L.) Genotypes for Antioxidant Defence System and Yield under High Temperature Stress
Authors: Pavithra N. , Jayalalitha K. , Sujatha T. , Harisatyanarayana N. , Lakshmi N. Jyothi , Roja V. 
Published: September 2024

Background: Blackgram is a short duration pulse crop which is sensitive to high temperatures. Raising global temperatures are becoming a serious threat to the production of blackgram by altering biochemical processes at cellular level. Hence, the present investigation was carried out for better understanding of genotypic variability and the biochemical mechanisms governing heat stress tolerance which can help in identifying heat tolerant blackgram genotypes that can yield better under climate change scenarios. Methods: Thirty blackgram genotypes selected from temperature induction response technique were evaluated for biochemical efficiency under natural high temperature conditions during summer, 2022 and 23. Field experiment was conducted at Agricultural College Farm, Acharya N.G Ranga Agricultural University, Agricultural College, Bapatla. Biochemical and yield parameters were recorded at flowering and the data were analyzed statistically and pooled. Result: The results of the study revealed that the genotypes TBG-129, LBG-1015, PU-1804 and PU-31 recorded higher seed yield indicating their ability to withstand high temperatures by up-regulating various biochemical pathways involved in increased production of proline, carotenoids and antioxidant defense enzymes that might have scavenged the free radicals that were produced due to high temperature stress, thereby preventing lipid peroxidation. Lower seed yield was recorded in TBG-125 and LBG-1023 which might be due to oxidative damage caused by higher accumulation of free radicals and poor scavenging activity of antioxidant enzymes. Moreover, the results of correlation analysis revealed that all the biochemical traits such as proline, carotenoids and antioxidant defense enzymes showed positive association with seed yield except free radicals and malondialdehyde. The principal component analysis results revealed considerable variability among the traits accounting for 80.0%. The genotypes TBG-129, LBG-1015, PU-1804 and PU-31 can be used in breeding programmes for development of heat tolerant genotypes.
Analisis Rantai Pasok Pengembangan Agroindustri MOCAF di Kabupaten Jember
Authors: Wibowo Yuli , Herlina Herlina , Soekarno Siswoyo , Wiyono Andi Eko , Aghata Ola Riska Aprilia Intan 
Published: September 2024

Jember Regency has great potential in the agricultural sector, with cassava being one of its key commodities. Cassava can be developed into MOCAF (Modified Cassava Flour), produced through a fermentation process that modifies cassava cells using lactic acid bacteria. The development of the MOCAF agroindustry in Jember Regency has promising prospects due to the abundant availability of raw materials and increasing market demand. However, supply chain management optimization is necessary to ensure the effectiveness and efficiency of MOCAF agroindustry development. This study aims to generate effective and efficient strategy recommendations for developing the MOCAF agroindustry. The study uses the Interpretative Structural Modeling (ISM) method to determine the most dominant supply chain actors and the Analytical Hierarchy Process (AHP) method to determine the priority strategies for MOCAF agroindustry development. Based on the identification results, the MOCAF supply chain structure consists of four members: cassava farmers, collectors, MOCAF producers, and consumers. Farmers and cassava collectors act as suppliers of raw materials to producers, who then process them into MOCAF and sell them to consumers. The main actor in the supply chain is the consumer the party who determines the sustainability of the MOCAF agro-industry. Meanwhile, the most appropriate and prioritized supply chain development strategy is partnering with farmers to strengthen institutions within the supply chain. This strategy aims to improve the effectiveness and efficiency of relationships among supply chain actors, especially between the MOCAF agroindustry, farmers, and cassava collectors. This partnership is expected to ensure product quality, increase efficiency, stabilize, and even reduce the price of raw materials, which can increase the demand for MOCAF. Other strategies resulting from the AHP analysis are complementary to encourage the increase in MOCAF demand.
Keywords: agroindustry, cassava, Jember Regency, MOCAF, supply chain
Enhancing Arabic Speaking Skills in Indonesian Madrasahs
Authors: Anggraini Niatri , Anwar Najih 
Published: September 2024

This research investigates the implementation of the Drilling Arabic Program (DAP) in enhancing speaking skills at the Junwangi Krian Siadoarjo Bilingual Madrasah Aliyah. Using qualitative methods, educators and students were surveyed to identify supporting and inhibiting factors and propose solutions. Findings reveal that while DAP is divided into planning, implementation, and evaluation stages, supporting factors include teacher competence and student enthusiasm, while inhibiting factors include teachers' lack of approach and inadequate infrastructure. Solutions include optimizing teacher development groups, improving time management, encouraging Fus-ha Arabic usage, and enhancing infrastructure. These results provide insights for improving Arabic language education in madrasahs and preserving Islamic linguistic heritage.
Highlight:
1. DAP Implementation Stages: Planning, executing, and evaluating Arabic speaking skill enhancement.2. Key Supporting Factors: Teacher competence, student enthusiasm, and available infrastructure.3. Addressing Challenges: Teacher approach, understanding, and infrastructure; solutions proposed.
Keyword: Drilling Arabic Program, Madrasah Aliyah, Speaking Skills, Qualitative Research, Language Education
Actors' Cooperation in Overcoming Street Children
Authors: Masfufah Dwi Nur , Agustina Isna Fitria 
Published: September 2024

This qualitative field research aimed to determine the synergy of actors in handling street children in Sidoarjo District, Indonesia. The study found that the implementation process of the policy for handling street children involved various stakeholders, both government and non-government, and was incorporated in a special coordination team called the Street Children Outreach Team. The team had a clear division of roles, and the stakeholders negotiated to avoid domination of one another's roles. The indicators and objectives that must be met by stakeholders in working together include the 4R approach, namely rights, responsibilities, revenues, and relationships. The study implies that effective collaboration among stakeholders is crucial in handling street children, and a clear division of roles can prevent conflicts and ensure the success of the program.
Highlight :

The study emphasizes the importance of a clear division of roles among stakeholders in handling street children.
The Street Children Outreach Team in Sidoarjo District involves various government and non-government stakeholders, working together with a 4R approach (rights, responsibilities, revenues, and relationships).
Effective collaboration among stakeholders is crucial in handling street children, and it can be achieved through the negotiation to avoid the domination of one another's roles.

Keywords: Synergy of actors, Street children, Stakeholders, Sidoarjo District, Indonesia
Firm Value Determinants in Chemical Sub-sector: Moderation by Firm Size (2017-2021)
Authors: Safitri Anik , Ernandi Herman 
Published: September 2024

This quantitative study investigates the influence of tax planning, profitability, liquidity, and dividend policy on firm value in the chemical sub-sector manufacturing companies listed on the IDX during 2017-2021. Employing Partial Least Square (PLS) analysis on a sample of 50 companies selected through purposive sampling, we found that tax planning and profitability significantly impact firm value, while liquidity and dividend policy exhibit no such effect. Additionally, firm size moderates the relationship between tax planning and dividend policy with firm value but does not moderate the relationship between liquidity and profitability with firm value. These findings provide insights for policymakers and practitioners regarding the significance of tax planning strategies and the interplay between firm size and key determinants of firm value within the chemical manufacturing sector
Highlights :

Tax planning and profitability significantly influence firm value in the chemical manufacturing sector.
Firm size moderates the relationship between tax planning and dividend policy with firm value.
Liquidity and dividend policy show no significant effect on firm value in the chemical manufacturing sector.

Keywords: Tax Planning, Firm Value, Partial Least Square (PLS), Chemical Manufacturing Sector, Firm Size Moderation
Financial development and environmental sustainability in Nigeria: Does institutional environment matter?
Authors: Ojeyinka Titus Ayobami , Oje grace Nyonnoh 
Published: September 2024

Abstract

Environmental sustainability has become a global agenda that every country strives to attain to promote prosperity and intergenerational wealth for the enhancement of human welfare and survival. It is against this backdrop that this study explores the effect of financial development on environmental sustainability as well as the moderating role of institutional quality on the nexus between the two variables. The study applies autoregressive distributed lags (ARDL) as the primary estimation technique while fully modified OLS and canonical cointegration regression are employed as robustness checks on the parameter estimates on annual data between 1986 and 2020. The study finds evidence of cointegration between environmental sustainability indicators and financial development. The outcomes from the baseline models suggest that financial development and weak institutional quality deteriorate environmental performance both in the short run and long run periods. However, additional findings from the paper affirm that institutional quality and financial development complement each other in promoting environmental sustainability in Nigeria. The results are consistent for the two indicators of environmental sustainability and robust to different estimation techniques. The study concludes that institutional quality plays a fundamental role by stimulating the favourable effect of financial development on environmental quality.
Physiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF
Authors: Chao Yali , Yuan Xueyan , Zhao Zhanqi , Frerichs Inéz , Li Zhe , Sun Qin , Chen Dongyu , Zhang Rui , Qiu Haibo , Liu Ling 
Published: September 2024

Abstract

Background
Prone positioning (PP) improves oxygenation in awake patients with acute hypoxemic respiratory failure (AHRF). However, the underlying mechanisms remain unclear in patients with diverse lung morphology. We aimed to determine the short-term effects of awake prone positioning (APP) in AHRF patients with focal and non-focal lung morphology.
Methods
This is a prospective physiological study. Twenty-four non-intubated patients with PaO2/FiO2 ≤ 300 mm Hg were included. Gas exchange, ventilation and perfusion distribution, and hemodynamics variables were recorded in the supine position (SP1), 2 h after PP, and 1 h after re-supine (SP2). Lung morphology was classified as focal and non-focal patterns using computed tomography.
Results
Twelve of the included patients were classified to the focal group and 12 to the non-focal group. PaO2/FiO2 improved after PP in all patients (161 [137, 227] mmHg vs. 236 [202, 275] mmHg, p < 0.001). Ventilation-perfusion (V/Q) matching increased after PP in all patients (61.9 [53.9, 66.5] vs. 77.5 [68.3, 80.0], p < 0.001). Shunt exhibited a significant decrease in patients of the non-focal group (28.6 [22.5, 30.3] vs. 11.3 [9.0, 14.5], p < 0.001), whereas no difference was found in the focal group after PP. Dead space decreased significantly in patients of the focal group (25.6 [21.5, 28.4] vs. 12.0 [10.8, 14.1], p < 0.001), whereas no difference was found in the non-focal group after PP.
Conclusions
APP improves V/Q matching by decreasing dead space in patients with focal lung morphology, and by decreasing shunt in patients with non-focal lung morphology.
Trial registration:
The study is registered in ClinicalTrials.gov (NCT04754113).
Association of anthropometric indices with menstrual abnormalities among female patients attending the Fertility Clinic of Nnamdi Azikiwe University Teaching Hospital, Nnewi
Authors: Onyejike Darlington , Okwuonu Ifeoma , Chukwuma Anita , Nwamaradi Albert , Amaonye Chinenye , Okafor Emeka , Agulanna Ambrose , Okeke Somadina , Ojemeni Chinenye , Ejiofor Dominic 
Published: September 2024

Abstract

Background
Menstrual abnormalities encompass a range of menstrual cycle disturbances, such as changes in the frequency, duration, or amount of bleeding. This study evaluated the association between menstrual abnormalities such as oligomenorrhea, menorrhagia and amenorrhea with anthropometric parameters such as BMI, WHR and WHtR among young women attending the Fertility Clinic of the Obstetrics and Gynaecology unit of NAUTH, Nigeria.
Methods
Random sampling technique was employed to select 200 women aged between 18–40 years, without any known medical condition that may affect menstrual function. Data were collected via questionnaires which composed of demographic information concerning menstruation, menstrual cycle and anthropometric parameters. The anthropometric parameters include height, weight, waist circumference and hip circumference.
Results
There was a statistically significant positive correlation between oligomenorrhea and BMI (r = .445, p = .001), WHR (r = .207, p = .003) and WHtR (r = .440, p = .001). There was a statistically non-significant negative correlation between menorrhagia and BMI (r = − .035, p = .618), WHR (r = − .010, p = .890) and WHtR (r = − .008, p = .912). There was a statistically non-significant very weak positive correlation between age and oligomenorrhea (p = .084) and menorrhagia (p = .104). Results from this study showed that there was no prevalence of amenorrhea among the study subjects.
Conclusions
Findings from this study indicate that obesity is a predisposing factor for oligomenorrhea. Age is not a predisposing factor for menorrhagia and oligomenorrhea. Amenorrhea is not a common menstrual disorder among young women in Anambra state, Nigeria. This study highlights the need for healthy body weight among young women.
Functional near-infrared spectroscopy study on inhibitory control ability of children with attention deficit hyperactivity disorder with methylphenidate therapy: An experimental, longitudinal, and neuroimaging study
Authors: Yang Jian , Liu Ziqi , Ren Yongying , Wang Xin , Li Guo , Tao Mengjiao , Zhang Jianzhao 
Published: September 2024

Abstract

Background
Executive dysfunction, particularly impairments in inhibitory control, is a key aspect of attention deficit hyperactivity disorder (ADHD). Methylphenidate (MPH) is the main treatment for ADHD; however, its effects on cortical activation and inhibitory control in children with ADHD have not been comprehensively studied. This study aimed to investigate the differences in functional near-infrared spectroscopy (fNIRS) outcomes related to inhibitory control improvement and cortical activation in children with ADHD.
Methods
Between May 2023 and December 2023, 14 children diagnosed with ADHD and treated with MPH were recruited, and 17 healthy children matched for age and sex were included. fNIRS was used to monitor brain activation in healthy children and children with ADHD before and after medication during Go/Nogo, Stroop, and flanker tasks. Differences in brain activation between healthy children and children with ADHD were compared before and after treatment.
Results
Swanson, Nolan, and Pelham IV rating scale revealed statistically significant improvements in inattention and hyperactivity-impulsivity in children with ADHD (P < 0.05). Behavior Rating Inventory of Executive Function Parent Edition revealed statistically significant improvements in working memory and monitoring ability after MPH treatment in children with ADHD (P < 0.05). After MPH treatment, the anterior cingulate cortex of the Stroop task significantly improved in children with ADHD (P < 0.05). The fNIRS activation levels in channels 9, 12, 21, and 42 were higher than those in healthy children during the go/no-go task before ADHD medication (P < 0.05). Before medication administration, no significant difference was observed in fNIRS activation between children with ADHD and healthy children during the Stroop and Flanker tasks (P > 0.05). When performing the Go/No-go task, the activation level of channel 7 fNIRS in children with ADHD was lower after treatment than before (P < 0.05). In the Stroop and flaker tasks, no significant differences were observed in fNIRS activation levels in children with ADHD before and after medication (P > 0.05).
Conclusions
After 8 weeks of treatment with methylphenidate, the behavioral data of children with ADHD showed improvement in the inhibition control neuropsychological test. The characteristic brain regions improved significantly when performing inhibitory control tasks and developed towards the activation direction of healthy children's brain regions.