bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abandonment process for injection well of China's Shenhua carbon dioxide geological storage demonstration project
Authors: Li Qi , Li Xiaying , Kuang Dongqin , Niu Zhiyong , Li Xiaochun , Lu Xutao , Ma Jianli , Wei Xiaochen 
Published: April 2017

AbstractThe abandonment process is a highly important part of project management for CO2 capture and storage (CCS) projects. For the first full procedure of a CO2 geological storage demonstration project in a deep saline aquifer in China, this paper describes the abandonment process of a CO2 operating well. The key idea that we advance is that wellbore integrity tests should be conducted before the abandonment, and consideration must be given to the CO2 corrosion resistance materials, the design method of sealing the plugs, monitoring tests (such as pressure tests), and the use of a long‐term monitoring system (such as the original pressure test and a packer isolation test every year). According to Chinese regulations and related experience in the oil and gas industry, the factors chosen are the pressure factor, cap rock, potable water layer, unexploited resource layer, suspected leak path, perforated zone, productive hydrocarbon zone without perforation, and water‐injection and waste‐water treatment layers. We intuitively evaluate and quantify the plugged zones using the modified analytical hierarchy process (M‐AHP) method to determine the positions of the plugs. Next, referring to the Chinese regulations on Well abandonment and inactive well practices, the last plug located in the Quaternary strata is compulsorily ensured, and the length of all plugs is also determined. Finally, the paper summarizes the methodology and presents suggestions for the abandonment process of the Shenhua CCS project. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd.
Prognostic survival value of retropharyngeal lymph node involvement in sinonasal tumors: A retrospective, descriptive, and exploratory study
Authors: Gangl Katharina , Nemec Stefan , Altorjai Gabriela , Pammer Johannes , Grasl Matthaeus Ch. , Erovic Boban M. 
Published: April 2017

AbstractBackgroundSinonasal carcinomas are rare. The purpose of this study was for us to present our assessment of the effects of retropharyngeal lymph node involvement at diagnosis on patient outcomes.MethodsRetropharyngeal lymph node involvement in 36 patients with sinonasal carcinoma was determined by radiology at initial presentation. Clinical outcome, in particular, overall survival (OS) and locoregional control, was assessed by Kaplan‐Meier analysis and log‐rank testing.ResultsRetropharyngeal lymph node involvement was associated with statistically significant decreased OS (P = .0066) in the patient collective. In the squamous cell carcinoma (SCC) subgroup (n = 23), decreased OS (P = .0046) and worse locoregional control (P = .0065) were observed. In these patients, decreased OS (P = .0423) and worse locoregional control (P = .0315) were also seen in the advanced tumor subgroup.ConclusionRetropharyngeal lymph node involvement at diagnosis is a significant prognostic factor for decreased OS and locoregional control in sinonasal carcinoma.
Differences and cause analysis of changes in lakes of different supply types in the north‐western Tibetan Plateau
Authors: Qiao Baojin , Zhu Liping 
Published: April 2017

AbstractMost lakes of the Tibetan Plateau were experiencing quick expansion in recent decades; a detailed study on the changes in lakes of different supply types will help to understand the cause of the changes by analysing area change of 34 lakes and water level change of eight lakes in the north‐western Tibetan Plateau. All lakes are classified into three types: non‐glacier‐fed lakes, upstream lakes and glacier‐fed lakes. The glacier‐fed lakes are separated into glacier‐fed_P1 (quick expansion region) and glacier‐fed_P2 (slow expansion region). Combining the changes in precipitation, temperature and evaporation, less precipitation may be the main reason for lake shrinkage from 1976 to 1996 and quickly increasing precipitation led to the lakes' expansion from 1996 to 2000. However, after 2000, upstream lakes remained in a stable state with slight variation, non‐glacier‐fed lakes and glacier‐fed_P2 lakes exhibited a slightly increasing rate with high precipitation and high evaporation, and glacier‐fed_P1 lakes still expanded quickly. On the basis of the assumption of same precipitation and evaporation, glacial meltwater may make an important contribution (>52%) to the increase in water storage of Bangdag Co and Meima Co. The results suggest that glacial meltwater augments the increased rate of glacier‐fed_P2 lakes and plays a much more important role in the expansion of glacier‐fed_P1 lakes compared to other lakes.
Use of a geographic information system to assess accessibility to health facilities providing emergency obstetric and newborn care in Bangladesh
Authors: Chowdhury Mahbub E. , Biswas Taposh K. , Rahman Monjur , Pasha Kamal , Hossain Mollah A. 
Published: April 2017

AbstractObjectiveTo use a geographic information system (GIS) to determine accessibility to health facilities for emergency obstetric and newborn care (EmONC) and compare coverage with that stipulated by UN guidelines (5 EmONC facilities per 500 000 individuals, ≥1 comprehensive).MethodsA cross‐sectional study was undertaken of all public facilities providing EmONC in 24 districts of Bangladesh from March to October 2012. Accessibility to each facility was assessed by applying GIS to estimate the proportion of catchment population (comprehensive 500 000; basic 100 000) able to reach the nearest facility within 2 hours and 1 hour of travel time, respectively, by existing road networks.ResultsThe minimum number of public facilities providing comprehensive and basic EmONC services (1 and 5 per 500 000 individuals, respectively) was reached in 16 and 3 districts, respectively. However, after applying GIS, in no district did 100% of the catchment population have access to these services. A minimum of 75% and 50% of the population had accessibility to comprehensive services in 11 and 5 districts, respectively. For basic services, accessibility was much lower.ConclusionAssessing only the number of EmONC facilities does not ensure universal coverage; accessibility should be assessed when planning health systems.
PGC‐1α in Melanoma: A Key Factor for Antioxidant Response and Mitochondrial Function
Authors: Torrens‐Mas Margalida , González‐Hedström Daniel , Abrisqueta Marta , Roca Pilar , Oliver Jordi , Sastre‐Serra Jorge 
Published: April 2017

ABSTRACTMelanocortin 1 receptor (MC1R) and BRAF are common mutations in melanoma. Through different pathways, they each regulate the expression of PGC‐1α, which is a key factor in the regulation of mitochondrial biogenesis and the antioxidant response. Our aim was to study the importance of the different regulatory characteristics of MC1R and BRAF on the pathways they regulate in melanoma. For this purpose, ROS production, levels of gene expression and enzymatic activities were analyzed in HBL and MeWo, with wild‐type MC1R and BRAF, and A375 cells with mutant MC1R and BRAF. HBL cells showed a functional MC1R‐PGC‐1α pathway and exhibited the lowest ROS production, probably because of a better mitochondrial pool and the presence of UCP2. On the other hand, MeWo cells showed elevated levels of PGC‐1α but also high ROS production, similar to the A375 cells, along with an activated antioxidant response and significantly low levels of UCP2. Finally, A375 cells are mutant for BRAF, and thus showed low levels of PGC‐1α. Consequently, A375 cells exhibited poor mitochondrial biogenesis and function, and no antioxidant response. These results show the importance of the activation of the MC1R‐PGC‐1α pathway for mitochondrial biogenesis and function in melanoma development, as well as BRAF for the antioxidant response regulated by PGC‐1α. J. Cell. Biochem. 118: 4404–4413, 2017. © 2017 Wiley Periodicals, Inc.
Association of R279Q and C1562T polymorphisms of matrix metalloproteinase 9 gene and increased risk for myocardial infarction in patients with premature coronary artery disease
Authors: Sheikhvatan Mehrdad , Boroumand Mohammad Ali , Behmanesh Mehrdad , Ziaee Shayan 
Published: April 2017

BackgroundA number of matrix metalloproteinase (MMP) gene polymorphisms has been identified which may be probably related to premature myocardial infarction (MI).ObjectiveWe assessed the relationship between the two polymorphisms of the MMP9 gene including R279Q and C1562T and occurrence of premature MI.MethodsThe study has two phases including a case‐control study as the first phase and cohort study as the second phase. Initially, 1000 patients with premature coronary artery disease were classified into MI and non‐MI groups. Genotyping of the polymorphism was conducted by PCRRFLP and high‐resolution melting techniques. Given the two conditions of patients residing in Tehran and faced with their first episode of MI, 640 of 1000 study samples previously followed up with a median follow‐up time of 45.74 months were assessed in a retrospective cohort phase regarding long‐term major adverse cardiac events (MACE).ResultsThe prevalence of wild, heterozygous, and mutant genotypes of R279Q polymorphism in MI group was 14.5%, 57.3%, and 28.2% and in non‐MI group was 36.9%, 38.4%, and 24.7%, respectively, with a considerable difference (P<.001). There was a significant difference in the prevalence of wild, heterozygous, and mutant genotypes of C1562T polymorphisms in MI group (12.4%, 41.2%, and 46.4%, respectively) and in non‐MI group (46.8%, 38.6%, and 14.7%, respectively; P<.001). No difference was found in total MACE‐free survival rate between genotypes of R279Q and C1562T polymorphisms.ConclusionC1562T and R279Q polymorphisms are associated with the susceptibility to premature MI, but cannot predict long‐term cardiac events in these patients.
Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
Authors: Morley John E. 
Published: April 2017

AbstractThe anorexia of aging was first recognized as a physiological syndrome 30 years ago. Its major causes are an alteration in fundal compliance with an increase in antral stretch and enhanced cholecystokinin activity leading to increased satiation.This anorexia leads to weight loss in aging persons and is one of the component causes of the aging related sarcopenia. This physiological anorexia also increases the risk of more severe anorexia when an older person has an increase in inflammatory cytokines such as occurs when they have an illness. This results in an increase in the anorexia due to cachexia in older persons.
Identification and characterization of variants and a novel 4 bp deletion in the regulatory region of SIX6, a risk factor for primary open‐angle glaucoma
Authors: Shah Mohd Hussain , Tabanera Noemi , Krishnadas Subbaiah Ramasamy , Pillai Manju R. , Bovolenta Paola , Sundaresan Periasamy 
Published: April 2017

AbstractBackgroundPrimary open‐angle glaucoma (POAG) is a complex disease of multigenic inheritance and the most common subtype of glaucoma. SIX6 encodes a transcription factor involved in retina, optic nerve, and pituitary development. Previous studies showed a genetic association between the SIX6 locus and POAG, identifying risk alleles. Whether these alleles are present also in the south Indian population is unclear.MethodsTo address this question, the SIX6 gene and an already characterized and highly conserved SIX6 enhancer (Ch14:60974427‐60974430) were sequenced in two south Indian cohorts, respectively, composed of 65/65 and 200/200 POAG cases/age‐matched controls. We next used Taqman‐based allelic discrimination assay to genotype a common variant (rs33912345: c.421A>C) and the rs1048372 SNP in two cohorts, respectively, composed of 557/387 and 590/448 POAG cases/age‐matched controls. An additional cohort of 153 POAG cases was subsequently recruited to assess the association of the rs33912345:c.421A>C and rs10483727 variants with more prominent changes in two POAG diagnostic parameters: retinal nerve fiber layer thickness and vertical cup/disc ratio, using spectral domain optical coherence tomography. The activity of the newly identified enhancer variants was assessed by transgenesis in zebrafish and luciferase assays.ResultsWe identified two known rare and two common variants in the SIX6 locus and a novel 4 bp deletion in the analyzed enhancer. Contrary to previous studies, we could not establish a significant association between the rs10483727 and rs33912345:c.421A>C variants and PAOG in the south Indian ethnicity but patients carrying the corresponding C or T risk alleles exhibited a dose‐dependent reduction of the thickness of the retinal nerve fiber layer and a significant increase in the vertical cup/disc ratio. Transgenesis in zebrafish and luciferase assays demonstrated that the newly identified 4 bp deletion significantly reduced reporter expression in cells of the retinal ganglion and amacrine layers, where human SIX6 is expressed.ConclusionAltogether, our data further support the implication of SIX6 variants as POAG risk factors and implicates SIX6 haploinsufficiency in POAG pathogenesis.
Studies on the Bioactivities of ACE‐inhibitory Peptides with Phenylalanine C‐terminus Using 3D‐QSAR, Molecular Docking and in vitro Evaluation
Authors: Qi Chunyan , Lin Guimei , Zhang Rong , Wu Wenjuan 
Published: April 2017

Abstract3D‐QSAR, molecular docking and activity evaluation were used to study the bioactivities of ACE‐inhibitory peptides with phenylalanine C‐terminus. Both CoMFA (Q2=0.773, R2=0.992) and CoMSIA (Q2=0.664, R2=0.990) models were constructed. According to the established models, four novel potent ACE‐inhibitory tripeptides GEF, VEF, VRF, and VKF were synthesized. The IC50 values were respectively determined to be 13 μM, 23 μM, 5 μM, and 11 μM by in vitro evaluation. The results show good agreement with the predicted values. The established models play an important role in revealing the structure‐activity relationship of ACE‐inhibitory peptides and designing novel peptides with enhanced biological activity.
Results of an innovative bulking agent in patients with stress urinary incontinence who are not optimal candidates for mid‐urethral sling surgery
Authors: Kowalik Claudia R. , Casteleijn Fenne M. , van Eijndhoven Hugo W. F. , Zwolsman Sandra E. , Roovers Jan‐Paul W. R. 
Published: April 2017

AimsTo assess the efficacy and safety of peri‐urethral bulking injections (PBI) with an innovative bulking material (PDMS‐U) in women with stress‐urinary incontinence (SUI) who are not optimal candidates for mid‐urethral sling surgery.MethodsA prospective study was performed in women with SUI who, for several reasons, have a relative contraindication for a mid‐urethral sling procedure.These reasons include: (i) recurrent SUI after a prior SUI surgical procedure; (ii) a history of oncologic gynaecological surgery; (iii) a history of neurologic disease resulting in voiding problems; (iv) a maximal flow rate of less than 15 mL per second or; (v) women with a contraindication for surgery with general or regional anaesthesia. All women were treated with PBI consisting of PDMS‐U, a bulking agent that polymerizes in situ. The primary outcome was subjective improvement, defined as “a little better” to “very much better” on the PGI‐I. Secondary outcomes included objective cure, disease specific quality of life and adverse events.ResultsSubjective improvement was reported by 18 (90%) of the 20 included patients. The subjective cure rate was 56% and the objective cure rate was 65%. There was a statistically significant improvement of all domain scores of the UDI‐6, IIQ‐7, and PISQ‐12 at 6 months follow up. Abnormal post voiding residual volume (>150 mL) was the most common adverse event (40%), but persisted in only one patient, based on the patient's preference for a catheter.ConclusionsPBI with PDMS‐U is a viable treatment option in women with a relative contra‐indication for mid‐urethral sling surgery.
Does psychosocial stress explain socioeconomic inequities in 9‐year weight gain among young women?
Authors: Ball Kylie , Schoenaker Danielle A.J.M. , Mishra Gita D. 
Published: April 2017

ObjectiveThis study investigated the contribution of psychosocial stress to mediating inequities in weight gain by educational status in a large cohort of young Australian women over a 9‐year follow‐up.MethodsThis observational cohort study used survey data drawn from 4,806 women, aged 22 to 27 years at baseline (2000), participating in the Australian Longitudinal Study on Women's Health, who reported their education level (2000), perceived stress (2003), and weight (2003 and 2012). Using a causal inference framework based on counterfactuals for mediation analysis, we fitted linear or logistic regression models to examine the total effect, decomposed into natural direct and indirect effects via perceived stress, of education level (highest qualification completed: up to year 12/trade or diploma vs. university) on weight change.ResultsWomen with lower education gained more weight over 9 years (6.1 kg, standard deviation [SD] 9.5) than women with higher education (3.8 kg, SD 7.7; P < 0.0001) and were more likely to be very or extremely stressed. The higher weight gain associated with low education was not mediated through perceived stress (per SD increase, percent mediated: 1.0%).ConclusionsEducation‐based inequities in weight gain over time were not attributable to greater psychosocial stress among women with lower education levels.
Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model
Authors: Han JianHua , Dzierlenga Anika L. , Lu Zhengqiang , Billheimer Dean D. , Torabzadeh Elmira , Lake April D. , Li Hui , Novak Petr , Shipkova Petia , Aranibar Nelly , Robertson Donald , Reily Michael D. , Lehman‐McKeeman Lois D. , Cherrington Nathan J. 
Published: April 2017

ObjectiveCharacteristic pathological changes define the progression of steatosis to nonalcoholic steatohepatitis (NASH) and are correlated to metabolic pathways. A common rodent model of NASH is the methionine and choline deficient (MCD) diet. The objective of this study was to perform full metabolomic analyses on liver samples to determine which pathways are altered most pronouncedly in this condition in humans, and to compare these changes to rodent models of nonalcoholic fatty liver disease (NAFLD).MethodsA principal component analysis for all 91 metabolites measured indicated that metabolome perturbation is greater and less varied for humans than for rodents.ResultsMetabolome changes in human and rat NAFLD were greatest for the amino acid and bile acid metabolite families (e.g., asparagine, citrulline, gamma‐aminobutyric acid, lysine); although, in many cases, the trends were reversed when compared between species (cholic acid, betaine).ConclusionsOverall, these results indicate that metabolites of specific pathways may be useful biomarkers for NASH progression, although these markers may not correspond to rodent NASH models. The MCD model may be useful when studying certain end points of NASH; however, the metabolomics results indicate important differences between humans and rodents in the biochemical pathogenesis of the disease.
Understanding predictors of continued long‐term pediatric cancer care across the region: A report from the Consortium for New England Childhood Cancer Survivors
Authors: Welch Jennifer J. G. , Kenney Lisa B. , Hirway Priya , Usmani G. Naheed , Kadan‐Lottick Nina , Grewal Satkiran S. , Huang Mary , Bradeen Heather , Ader Jeremy , Diller Lisa , Schwartz Cindy L. 
Published: April 2017

BackgroundMany survivors of childhood cancer do not receive recommended longitudinal oncology care. Factors present at the time of childhood cancer diagnosis may identify patients who are vulnerable to poor adherence to follow‐up.MethodsThis cohort of survivors of acute lymphoblastic leukemia (ALL) diagnosed from 1996 to 1999 at seven Consortium for New England Childhood Cancer Survivors institutions was evaluated for attendance at oncology clinics at 5 and 10 years from diagnosis. Demographic, socioeconomic, disease, and treatment characteristics were analyzed as risk factors for nonadherence to follow‐up.ResultsOf 317 patients, 90% were alive 5 years from diagnosis and 88% of those remained in active follow‐up. At 10 years from diagnosis, 88% were alive, 73% of whom continued in active follow‐up. Insurance status at diagnosis was significantly associated with adherence at both 5 and 10 years. At 10 years, initial enrollment on therapeutic study was associated with increased attendance and central nervous system (CNS) leukemia with decreased attendance. In multivariable modeling of follow‐up at 5 years, patients who were adults were less likely to participate and those with private insurance at diagnosis more likely to participate. At 10 years, insurance status at diagnosis remained a predictor of adherence to follow‐up.ConclusionsIn this regional cohort, many patients who are survivors of ALL continue to participate in oncology care at 5 and 10 years from diagnosis. Factors known at diagnosis including insurance status, CNS leukemia, older age, and enrollment on therapeutic study were associated with differential attendance to follow‐up visits.
The clinical severity of hemoglobin S/Black (Aγδβ)0‐thalassemia
Authors: Cancio Maria I. , Aygun Banu , Chui David H. K. , Rothman Jennifer A. , Scott J. Paul , Estepp Jeremie H. , Hankins Jane S. 
Published: April 2017

AbstractHemoglobin S/Black (Aγδβ)0‐thalassemia is a rare sickle cell disease (SCD) variant. On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course. We report the clinical and laboratory data of nine patients whose diagnoses were confirmed by DNA‐based techniques. Despite having mild anemia and high fetal hemoglobin level postinfancy, these patients developed many of the classic complications of SCD, including vaso‐occlusive crisis, acute chest syndrome, avascular necrosis, and cholelithiasis. On the basis of these findings, we recommend that patients with this rare disorder receive specialized hematology care according to SCD guidelines.
Clinical outcome of childhood chronic immune thrombocytopenia: A 38‐year experience from a single tertiary center in Thailand
Authors: Chotsampancharoen Thirachit , Sripornsawan Pornpun , Duangchoo Sarapee , Wongchanchailert Malai , McNeil Edward 
Published: April 2017

AbstractBackgroundThere is limited information on long‐term follow‐up and prognostic factors for remission among children diagnosed with chronic immune thrombocytopenia (ITP). The aim of this study was to determine clinical outcomes and factors influencing remission in childhood chronic ITP.Study DesignThe hospital records of children aged 0–15 years diagnosed with chronic ITP were retrospectively reviewed. Kaplan–Meier curves were fit to estimate the median time to complete remission with 95% confidence intervals (CIs). Multivariate Cox proportional hazards regression models were used to identify independent factors for remission.ResultsA total of 113 patients were included in the analysis. The number of children achieving complete remission was 49 (46%) and the median time to remission was 7.1 years (95% CI: 4.8–11.0). The remission rates at 3, 5, 10, and 20 years were 25, 43, 60, and 75%, respectively. Factors influencing remission were platelets >60 × 109/L at the onset of chronic ITP (hazard ratio [HR]: 7.24, 95% CI: 3.0–17.5) and treatment with intravenous immunoglobulin (HR: 0.37, 95% CI: 0.16–0.84). Age, gender, and clinical factors at the time of newly diagnosed ITP including bleeding manifestations, onset of symptoms, and history of preceding infection and vaccination were not predictive of remission.ConclusionThe spontaneous complete remission rates of chronic ITP were 43 and 60% at 5 and 10 years, respectively, and reached 75% at 20 years. A higher platelet level at diagnosis of chronic ITP and form of treatment were statistically significant indicators for achieving complete remission.