bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atogepant for migraine prevention: a meta-analysis of safety and efficacy in adults
Authors: Raja Adarsh , Asim Rabia , Shuja Muhammad Hamza , Raja Sandesh , Muhammad Tazheen Saleh , Bajaj Simran , Ansari Abdul Hadi , Ali Hamza , Magsi Iffat Ambreen , Faridi Muhammad Hammad , Sheikh Hamza Ali Hasnain , Imran Muhammad Junaid , Ahmed Muhammad , Asghar Muhammad Sohaib 
Published: September 2024

BackgroundMigraine is a neurological condition marked by frequent headaches, which tends to be accompanied by nausea and vomiting in severe instances. Injectable therapies for migraine, such as monoclonal antibodies that target calcitonin gene-related peptide (CGRP), have proven to be effective and safe. While various oral drugs are available, none have been developed for migraines. Patients prefer oral therapies because they are easier to use, making atogepant, an orally accessible small-molecule CGRP receptor antagonist, a possible alternative.ObjectivesThis systematic review and meta-analysis compared the safety and effectiveness of atogepant with placebo in treating migraine.MethodsAdhering to the PRISMA guidelines, we meticulously gathered randomized controlled trials (RCTs) from databases including the Cochrane Library, PubMed, Science Direct, and ClinicalTrials.gov. Studies comparing atogepant with placebo and reporting monthly migraine days (MMDs) as the primary outcome along with secondary outcomes such as monthly headache days and acute medication use days were included. Two independent reviewers conducted the data extraction and quality assessment. Statistical analyses were carried out using RevMan, utilizing risk ratios for dichotomous outcomes and mean differences for continuous outcomes, and a random-effects model.ResultsOur primary outcome was the change in MMDs over 12 weeks, which showed a significant reduction with atogepant at dosages of 10, 30, and 60 mg. Secondary outcomes, such as monthly headache days, proportion of patients achieving a ≥ 50% reduction in MMDs, acute medication use days, and patient-reported outcomes, consistently showed that atogepant outperformed placebo, highlighting its effectiveness in reducing the migraine burden.ConclusionHigher doses of atogepant are more effective in lowering migraine and headache-related days and increasing quality of life metrics. However, this is accompanied by an increased incidence of adverse events, suggesting the need for careful dose optimization to balance the benefits and risks.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=563395. Unique Identifier: CRD42024563395.
Immunocytes do not mediate food intake and the causal relationship with allergic rhinitis: a comprehensive Mendelian randomization
Authors: Zhang Zhi-qiang , Li Jing-yang , Bao You-wei , Song Yu-Qi , Song Dong-xu , Wang Cheng , Zhu Xin-hua 
Published: September 2024

BackgroundObservational studies indicate a correlation between food intake and allergic rhinitis. The potential interplay between the immune system and allergic rhinitis might contribute causally to both food intake and allergic rhinitis, providing promising therapeutic avenues. However, elucidating the causal relationship and immune-mediated mechanisms between food intake and allergic rhinitis remains a pending task.MethodsWe utilized a two-sample Mendelian randomization (MR) methodology to explore the causal relationship between food intake and allergic rhinitis. Furthermore, we investigated the potential causal relationship of immune cell signals with allergic rhinitis, as well as the potential causal relationship between food intake and immune cell signals. Moreover, employing both two-step Mendelian randomization and multivariable Mendelian randomization, we delved into the mediating role of immune cell signals in the causal relationship between food intake and allergic rhinitis. Leveraging publicly accessible genetic datasets, our analysis encompassed 903 traits, comprising 171 food intake features, 731 immune cell features, and one trait related to allergic rhinitis.ResultWe found causal relationships between seven types of food intake and allergic rhinitis, as well as between 30 immune cell phenotypes and allergic rhinitis. Furthermore, our two-step Mendelian randomization analysis and multivariable Mendelian randomization analysis indicate that immune cells do not mediate the causal relationship between food intake and allergic rhinitis.ConclusionTo the best of our knowledge, we are the first to incorporate a large-scale dataset integrating immune cell features, food intake features, and allergic rhinitis into Mendelian randomization analysis. Our research findings indicate that there are causal relationships between six types of food intake and allergic rhinitis, as well as between 30 immune cell phenotypes and allergic rhinitis. Additionally, immune cells do not mediate these relationships.
Undernutrition and dietary diversity score and associated factors among lactating mothers in Northwest Ethiopia
Authors: Belay Mahider Awoke 
Published: September 2024

BackgroundMaternal undernutrition negatively influences both maternal and child health, as well as economic and social development. Limited research has been conducted on both the nutritional status and dietary diversity score among lactating mothers. Therefore, the present study aimed to determine the magnitudes of undernutrition and dietary diversity scores and their associated factors among lactating mothers in Bahir Dar City, Northwest Ethiopia.MethodsA community-based cross-sectional study was conducted from March to May 2021. Systematic random sampling and interview-administered questionnaires were employed. Dietary diversity score and nutritional status were measured using a 24-h recall and body mass index (BMI), respectively. Data entry and analysis were performed using EpiData version 3.02 and SPSS version 24 software, respectively. Both the bivariable and multivariable binary logistic regression analyses were performed, and the strength of association was measured in terms of odds ratio.ResultsThe prevalence of undernutrition and low dietary diversity scores among respondents were 13.5% (95% CI; 10.4, 17.2) and 64.8% (95% CI, 60.0, 69.4), respectively. The significant factors for undernutrition were being young [AOR = 2.30, 95% CI (1.09, 5.43)], having low dietary diversity score [AOR = 2.26, 95% CI (1.01,5.10)], having poor nutritional knowledge [AOR = 2.56, 95% CI (1.03, 6.51)], meal frequency less or equal to 3 times per day [AOR = 4.06, 95% CI (0.71, 9.65)], educational status being primary school [AOR = 3.20, 95% CI (1.01, 9.11)], and educational status of husband being secondary school [AOR = 2.28, 95% CI (1.25, 8.53)]. Age between 20 and 30 years [AOR = 1.46, 95% CI (1.01, 2.48)], being food insecure [AOR = 3.41, 95% CI (1.21, 9.63)], and being poorest [AOR = 2.31, 95% CI (1.02, 5.32)] were associated with the dietary diversity score.ConclusionA high prevalence of undernutrition and low dietary diversity scores were recorded in the current study area. Age, educational status of lactating mothers and their husbands, nutritional knowledge, dietary diversity, and meal frequency were significant factors associated with undernutrition. Age, food security, and wealth index were associated with the dietary diversity score.
Urachal adenocarcinoma with cervical invasion misdiagnosed as primary cervical adenocarcinoma: a case report and literature review
Authors: Wang Yiran , Li Maomao , Yang Kaixuan , Li Qingli , Wang Ping 
Published: September 2024

BackgroundUrachal carcinoma (UrC) is a rare malignancy with no known specific early symptoms. It is often diagnosed at advanced stages and is associated with poor prognosis.Case presentationThis study presents a rare case of urachal adenocarcinoma (UrAC) invading the bladder and vagina in a female patient. Initially, the patient was misdiagnosed as having a primary cervical adenocarcinoma 2.5 years prior. Subsequently, anterior pelvic exenteration and bilateral ureterocutaneostomies were performed. Twenty months after the first surgery, the patient was diagnosed with rectal metastasis and received gemcitabine chemotherapy. After achieving a stable disease state, the patient underwent laparoscopic ultralow rectal anterior resection, ultralow anastomosis of the sigmoid colon and rectum, prophylactic transverse colostomy, and right common iliac and external iliac lymph node dissection. The patient then received a cycle of postoperative chemotherapy with oxaliplatin and capecitabine; however, treatment was stopped due to adverse reactions. The patient continues to receive regular follow-ups, and her general condition is good.ConclusionsUrC is rare, and preoperative differential diagnosis is difficult. This is the first report of UrC being misdiagnosed as cervical cancer. The presented case highlights the importance of accurate histopathological examination and comprehensive analysis. Anterior pelvic exenteration was also identified as a potentially effective treatment strategy for patients with local pelvic recurrence of UrC, although further investigation is required.
The Spectrum of clinical manifestations in newborns with the COQ4 mutation: case series and literature review
Authors: Pan Pianpian , Zhou Na , Sun Yi , Chen Zhengrong , Han Jin , Zhou Wei 
Published: September 2024

BackgroundCoenzyme Q10 (CoQ10) plays an important role in the electron transport chain within the human mitochondrial respiratory chain. The manifestations of this deficiency exhibit a diverse range. This study investigates the clinical manifestations of primary coenzyme Q10 deficiency in neonates with the COQ4 mutation to improve the diagnosis of the disease and the prognosis through targeted treatment.MethodsWe report 4 patients with primary coenzyme Q10 deficiency by COQ4 variants in neonates. A comprehensive literature search and review for original articles and case reports with COQ4 mutation published from January 1989 to November 2023 was performed through Pubmed. We review clinical manifestations, diagnostic approaches, and treatment monitoring in these and 20 previously reported patients.ResultsWithin the cohort of four cases examined, three females and one male were identified from two distinct families. Specifically, case 1 and 2 consisted of monoamniotic twins. Cases 3 and 4 were siblings. A comprehensive review of 20 cases involving neonatal-onset COQ4 mutation was conducted. Half of the cases are Chinese. There was no statistically significant difference in the mortality between Chinese (9/12, 75%) and other regions (11/12, 91.7%) (P = 0.27). The survival time for the 24 cases was 60.0 ± 98.0 days (95% confidence interval CI: 0–252.0 days). The incidence of prenatal abnormalities in preterm infants was significantly higher than that in full-term infants (66.7% vs. 16.7%, P = 0.02). Hyperlactatemia was one of the most common manifestations, accounting for 75% of cases (18/24). Twenty of the 24 cases were diagnosed by whole exome sequencing. Only 9 patients received exogenous coenzyme Q10 treatment, and all the 4 surviving patients received coenzyme Q10 supplementation.ConclusionThe prognosis of COQ4 mutation in the neonatal period indicates a low survival rate and an poor prognosis. This may be due to the incomplete understanding of the mechanism of how COQ4 gene defects lead to coenzyme Q10 deficiency and why CoQ10 supplementation does not respond well to treatment. To improve the diagnostic rate, in addition to genetic testing, mitochondrial functional verification should be prioritized in southern China, where the incidence is relatively high. It will facilitate more in-depth mechanistic studies.
Interstitial lung disease associated with ALK inhibitors and risk factors: an updated comparative pharmacovigilance analysis
Authors: Dong Junli , Li Lulu , Deng Tiying , Song Haibin , Zhang Shaohui , Zhong Minyu 
Published: September 2024

BackgroundInhibitors of the anaplastic lymphoma kinase (ALK) gene mutation are first-line treatments in patients with ALK-positive lung cancer. The FDA label warns of the risk of interstitial lung disease (ILD) in patients receiving ALK TKIs. However, ILD associated with ALK TKIs is not fully understood. The aim of this study was to characterize the features of ALK TKI-related ILD and to explore risk factors for ALK TKI-related ILD.MethodsFDA’s Adverse Event Reporting System (FAERS) reports from 2011 Q1 to 2023 Q2 were extracted and combined. Standardized MedDRA queries (SMQs) were used to search for AEs at the preferred term (PT) level. Four algorithms were employed to quantify the signals of ILD associated with ALK TKIs. The risk of ILD was further analyzed using logistic regression.ResultsA total of 20,064 reports of ALK TKIs and 640 (3.2%) reports of ILD AEs were extracted. Significant disproportionality was detected in all five ALK TKIs. Interstitial lung disease and pneumonitis were the most common lung toxicities induced by ALK TKIs. Results of further analyses revealed a different spectrum of lung toxicity among the various TKIs. The median time to onset of ILD related to ALK TKIs was 53 days (Q1:12, Q3:209), and more than 70% of AEs occurred within the first 2 months. Logistic regression analysis and risk prediction model both showed that different ALK TKIs and their combination with PPIs, amlodipine, and magnesium oxide were independent risk factors for ILD (p&lt;0.05).ConclusionALK TKIs have different safety profiles regarding lung toxicity, which normally occurs within the first 2 months. Administration in combination with PPIs, amlodipine, and magnesium oxide significantly increases the risk of ILD. These results provide risk prediction for ILD related to ALK TKIs and support pharmacovigilance to promote safe prescribing in oncology.
Hypoventilation training including maximal end-expiratory breath holding improves the ability to repeat high-intensity efforts in elite judo athletes
Authors: Woorons X. , Faucher C. , Dufour S. P. , Brocherie F. , Robach P. , Connes P. , Brugniaux J. V. , Verges S. , Gaston A. F. , Millet G. , Dupuy O. , Pichon A. 
Published: September 2024

PurposeTo investigate the effects of a repeated-sprint training in hypoxia induced by voluntary hypoventilation at low lung volume (RSH-VHL) including end-expiratory breath holding (EEBH) of maximal duration.MethodsOver a 4-week period, twenty elite judo athletes (10 women and 10 men) were randomly split into two groups to perform 8 sessions of rowing repeated-sprint exercise either with RSH-VHL (each sprint with maximal EEBH) or with unrestricted breathing (RSN, 10-s sprints). Before (Pre-), 5 days after (Post-1) and 12 days after (Post-2) the last training session, participants completed a repeated-sprint ability (RSA) test on a rowing ergometer (8 × 25-s “all-out” repetitions interspersed with 25 s of passive recovery). Power output (PO), oxygen uptake, perceptual-motor capacity (turning off a traffic light with a predetermined code), cerebral (Δ[Hbdiff]) and muscle (Δ[Hb/Mb]diff) oxygenation, cerebral total haemoglobin concentration (Δ[THb]) and muscle total haemoglobin/myoglobin concentration (Δ[THb/Mb]) were measured during each RSA repetition and/or recovery period.ResultsFrom Pre-to Post-1 and Post-2, maximal PO, mean PO (MPO) of the first half of the test (repetitions 1–4), oxygen uptake, end-repetition cerebral Δ[Hbdiff] and Δ[THb], end-repetition muscle Δ[Hb/Mb]diff and Δ[THb/Mb] and perceptual-motor capacity remained unchanged in both groups. Conversely, MPO of the second half of the test (repetitions 5–8) was higher at Post-1 than at Pre-in RSH-VHL only (p &lt; 0.01), resulting in a lower percentage decrement score over the entire RSA test (20.4% ± 6.5% vs. 23.9% ± 7.0%, p = 0.01). Furthermore, MPO (5–8) was greater in RSH-VHL than in RSN at Post-1 (p = 0.04). These performance results were accompanied by an increase in muscle Δ[THb/Mb] (p &lt; 0.01) and a concomitant decrease in cerebral Δ[THb] (p &lt; 0.01) during the recovery periods of the RSA test at Post-1 in RSH-VHL.ConclusionFour weeks of RSH-VHL including maximal EEBH improved the ability of elite judo athletes to repeat high-intensity efforts. The performance improvement, observed 5 days but not 12 days after training, may be due to enhanced muscle perfusion. The unchanged oxygen uptake and the decrease in cerebral regional blood volume observed at the same time suggest that a blood volume redistribution occurred after the RSH-VHL intervention to meet the increase in muscle perfusion.
ame-miR-5119-Eth axis modulates larval-pupal transition of western honeybee worker
Authors: Dong Shunan , Li Kunze , Zang He , Song Yuxuan , Kang Jing , Chen Ying , Du Liting , Wang Ning , Chen Dafu , Luo Qingming , Yan Tizhen , Guo Rui , Qiu Jianfeng 
Published: September 2024

The miRNA plays a key role in the regulation of hormone signaling in insects. The pathways by which miRNAs affect hormone levels are unclear in the honeybee (Apis mellifera), an indispensable pollinator in nature. In this study, ame-miR-5119 was overexpressed and knocked down in larvae by feeding mimics and inhibitors, respectively, and we determined that ame-miR-5119 regulates hormone signaling through the target gene ecdysis triggering hormone (Eth), which affects the larval-pupal transition of workers. The results showed that ame-miR-5119 with a length of 19 nt targets six genes related to the hormone pathway. We focused on Eth and found that ame-miR-5119 and Eth exhibited reverse expression patterns during the transition from larval to pupal stages in workers. Dual luciferase assay confirmed the negative regulatory between ame-miR-5119 and Eth. Overexpression of ame-miR-5119 decreased the mRNA level of Eth, and the Eth receptor (Ethr) expression was not significantly affected, but the expression levels of juvenile hormone (JH) pathway related genes juvenile hormone acid methyltransferase (Jhamt) and Krüppel homolog 1 (Kr-h1) were significantly reduced. In contrast, knockdown of ame-miR-5119 increased the mRNA level of Eth, and the expression of Ethr, Jhamt and Kr-h1 was significantly upregulated. ame-miR-5119 did not affect larval body weight. The number of larvae overexpressing ame-miR-5119 survived in the prepupal stage was lower than that in the control group, and the number of pupations reduced at 11-day-old. The number of larvae that knocked down ame-miR-5119 survived in the prepupal stage was significantly higher than that in the control group, and the number of pupations increased at 11-day-old. These results indicated that ame-miR-5119 negatively regulates the expression of Eth, indirectly inhibits the expression of Ethr, Jhamt, and Kr-h1, and affects the JH biosynthesis, thereby preventing the metamorphic transition from larva to pupa in worker bees. These findings provide evidence that the miRNA regulation of hormone levels in honey bees.
The impact of exercise intensity on depression in fibromyalgia: a randomized controlled trial
Authors: Vilarino Guilherme Torres , Coimbra Danilo Reis , Neiva Henrique Pereira , Andrade Alexandro 
Published: September 2024

BackgroundFibromyalgia (FM) is characterized by widespread chronic pain. Although pain is the main symptom, approximately 90% of patients have depression. This study aimed to analyze the effects of Resistance Training (RT) with low and high intensity on depression in patients with FM.MethodsThirty-eight women with FM and 31 healthy women were allocated to the low-intensity, high-intensity, preferred-intensity, and control groups. The patients underwent 8 weeks of supervised RT, with two sessions per week of approximately 1 h. The low-intensity resistance training group (LIRT) performed two sets of 12 maximum repetitions. The high-intensity resistance training group (HIRT) performed four sets with six maximum repetitions, and the preferred intensity group (PI) performed three sets, with eight to 12 repetitions, according to the patient’s tolerance. The healthy control group did not perform any type of exercise. Depression was assessed using the Beck depression inventory before the start of the intervention, after 4 and 8 weeks.ResultsFM patients have higher levels of depression than women without the disease. After 4 weeks, there was a difference in depressive symptoms between the HIRT and LIRT (p = 0.048), and the PI and LIRT (p = 0.048).ConclusionPrescribing RT with low or high intensity did not significantly reduce depression in patients with FM after 8 weeks, however, analyses between groups after 4 weeks indicated that low-intensity training is more effective than high-intensity training. The prescription of RT exercise to FM could vary among low, high, and preferred intensity, following the patient’s tolerance for pain.Clinical trial registrationhttps://ensaiosclinicos.gov.br/rg/RBR-74pcmw, RBR-74pcmw.
Perception of success among adults practicing various fighting arts
Authors: Ambroży Tadeusz , Serafin Natalia , Pawelec Przemysław , Piepiora Paweł Adam , Borysiuk Zbigniew , Kindzer Bogdan , Kasicki Krzysztof , Rydzik Łukasz , Cynarski Wojciech J. 
Published: September 2024

Problem statementGoal orientations, which influence learning and motivation, are categorized into task orientation (focused on skill development and personal mastery) and ego orientation (focused on outperforming others and gaining recognition). This study aims to explore how different demographics perceive success in martial arts.Approach and purposeThe research questions focused on identifying correlations between perceptions of success and demographic factors: (1) sex, (2) age, (3) type of martial art practiced, and (4) nationality. These factors were examined to understand their impact on success perceptions among martial arts practitioners.Materials and methodsThe study utilized the Perception of Success Questionnaire (POSQ) to gather data from 268 participants—142 from Poland and 126 from Ukraine—selected through voluntary participation. Statistical analyses included standard deviation, coefficient of variability, Spearman’s rank correlation, and ANOVA for multifactor analysis.ResultsThe study revealed a weak correlation between the type of martial art practiced and perception of success (rs = 0.38), indicating that the style of martial art has limited influence on success perception. There was a weak correlation between nationality and perception of success (rs = 0.20), suggesting cultural factors do not play a role. A strong correlation was found between age and perception of success (rs = 0.80), highlighting how perceptions evolve with age. A significant correlation was also found between sex and perception of success (rs = 0.90), which may reflect broader cultural patterns influenced by globalization.ConclusionWhile the study identifies important demographic correlations affecting perceptions of success in martial arts, the findings are constrained by the sample size and demographic distribution, which limits the generalizability of the results. Further research with a larger and more diverse sample is recommended to deepen understanding.