bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of Porous Organic Polymer ASEIs for Zn Anode Protection and Ion Migration Regulation
Authors: Bian Haifeng , Xue Ge , Bin Duan , Jia Shunshun , Zhou Qing , Lu Hongbin , Meng Xiangkang 
Published: October 2024

AbstractRechargeable aqueous Zn metal batteries (RAZMBs) are considered as a competitive alternative to the next generation of energy storage system. However, the Zn stripping/plating reversibility is greatly limited by the dendrite growth and the side reactions on Zn anode. In virtue of the excellent protection and ion migration regulation effects, porous organic polymer artificial solid electrolyte interphases (POPASEIs) have attracted widespread attention in stabilizing Zn anode. This article summarizes the progress of Zn anode POPASEIs in recent years, divided into two categories according to the polymer matrix: porous polymer‐based POPASEIs and nonporous polymer‐based POPASEIs. The porous polymer‐based POPASEIs can be divided into porous coordination organic polymer (PCOOP)‐based and porous covalent organic polymers (PCVOP)‐based ASEIs according to the chemical structure, while nonporous polymer‐based POPASEIs can be divided into four types according to the pore‐forming strategies, including phase separation‐induced POPASEIs, template‐assisted POPASEIs, fiber‐formed POPASEIs, porous filler‐modified POPASEIs. In addition, the structural advantages, challenges, and perspectives of POPASEIs for Zn anode are also discussed to provide guidance for the further research and development of Zn anode ASEIs.
Accelerating Oral Wound Healing Using Bilayer Biomaterial Delivery of FTY720 Immunotherapy
Authors: Toma Afra I. , Shah Daniel , Roth Daniela , Piña Jeremie Oliver , Hymel Lauren , Turner Thomas , Kamalakar Archana , Liu Ken , Bartsch Perry , Jacobs Leon , D'Souza Rena , Liotta Dennis , Botchwey Edward , Willett Nick J. , Goudy Steven L. 
Published: October 2024

AbstractOrofacial clefts are the most common congenital craniofacial anomaly. Adverse healing following cleft palate repair can lead to oronasal fistula (ONF), a persistent connection between the oral and nasal cavities. Although human allograft tissues are currently the gold standard for ONF repair, these methods carry risks of infection and rejection, often requiring surgical revision. Immunoregenerative therapies present a novel alternative approach to harness the body's immune response and enhance the wound healing environment. An FDA‐approved immunomodulatory drug, FTY720, is repurposed to reduce lymphocyte egress and induce immune cell fate switching toward pro‐regenerative phenotypes. In this study, a bilayer biomaterial system is engineered using Tegaderm to secure and control the delivery of FTY720‐nanofiber scaffolds (FTY720‐NF). The release kinetics of the bilayer FTY720‐NF is optimized to maintain drug release for up to 7 days, ensuring safe transdermal absorption and tissue biodistribution. The comprehensive immunophenotyping results demonstrate a regenerative state transition in hybrid immune cells recruited to the wound site. Further, histological evaluations reveal a significant ONF closure in mice by day 7 following bilayer FTY720‐NF implantation. These findings demonstrate the utility of immunomodulatory strategies for oral wound healing, better positing the field to develop more efficacious treatment options in pediatric patients.
Shape‐Morphing in Oxide Ceramic Kirigami Nanomembranes
Authors: Kim Minsoo , Kim Donghoon , Mirjolet Mathieu , Shepelin Nick A. , Lippert Thomas , Choi Hongsoo , Puigmartí‐Luis Josep , Nelson Bradley J. , Chen Xiang‐Zhong , Pané Salvador 
Published: October 2024

AbstractInterfacial strain engineering in ferroic nanomembranes can broaden the scope of ferroic nanomembrane assembly as well as facilitate the engineering of multiferroic‐based devices with enhanced functionalities. Geometrical engineering in these material systems enables the realization of 3‐D architectures with unconventional physical properties. Here, 3‐D multiferroic architectures are introduced by incorporating barium titanate (BaTiO3, BTO) and cobalt ferrite (CoFe2O4, CFO) bilayer nanomembranes. Using photolithography and substrate etching techniques, complex 3‐D microarchitectures including helices, arcs, and kirigami‐inspired frames are developed. These 3‐D architectures exhibit remarkable mechanical deformation capabilities, which can be attributed to the superelastic behavior of the membranes and geometric configurations. It is also demonstrated that dynamic shape reconfiguration of these nanomembrane architectures under electron beam exposure showcases their potential as electrically actuated microgrippers and for other micromechanical applications. This research highlights the versatility and promise of multi‐dimensional ferroic nanomembrane architectures in the fields of micro actuation, soft robotics, and adaptive structures, paving the way for incorporating these architectures into stimulus‐responsive materials and devices.
Dual‐Seed Strategy for High‐Performance Anode‐Less All‐Solid‐State Batteries
Authors: Sohn Yeeun , Oh Jihoon , Lee Jieun , Kim Hyunjae , Hwang Insu , Noh Gyeongho , Lee Taeyong , Kim Ji Young , Bae Ki Yoon , Lee Taegeun , Lee Nohjoon , Chung Woo Jun , Choi Jang Wook 
Published: October 2024

AbstractInterest in all‐solid‐state batteries (ASSBs), particularly the anode‐less type, has grown alongside the expansion of the electric vehicle (EV) market, because they offer advantages in terms of their energy density and manufacturing cost. However, in most anode‐less ASSBs, the anode is covered by a protective layer to ensure stable lithium (Li) deposition, thus requiring high temperatures to ensure adequate Li ion diffusion kinetics through the protective layer. This study proposes a dual‐seed protective layer consisting of silver (Ag) and zinc oxide (ZnO) nanoparticles for sulfide‐based anode‐less ASSBs. This dual‐seed‐based protective layer not only facilitates Li diffusion via multiple lithiation pathways over a wide range of potentials, but also enhances the mechanical stability of the anode interface through the in situ formation of a Ag–Zn alloy with high ductility. The capacity retention during full‐cell evaluation is 80.8% for 100 cycles when cycled at 1 mA cm−2 with 3 mAh cm−2 at room temperature. The dual‐seed approach provides useful insights into the design of multi‐seed concepts in which, from a mechanochemical perspective, various lithiophilic materials synergistically impact upon the anode‐less interface.
3D Bioprinting of Liquid High‐Cell‐Proportion Bioinks in Liquid Granular Bath
Authors: Jiang Jinhong , Yuan Chenhui , Zhang Xinyu , Gu Lin , Yao Yudong , Wang Xueping , He Yong , Shao Lei 
Published: October 2024

AbstractEmbedded 3D bioprinting techniques have emerged as a powerful method to fabricate 3D engineered constructs using low strength bioinks; however, there are challenges in simultaneously satisfying the requirements of high‐cell‐activity, high‐cell‐proportion, and low‐viscosity bioinks. In particular, the printing capacity of embedded 3D bioprinting is limited as two main challenges: spreading and diffusion, especially for liquid, high‐cell‐activity bioinks that can facilitate high‐cell‐proportion. Here, a liquid‐in‐liquid 3D bioprinting (LL3DBP) strategy is developed, which used a liquid granular bath to prevent the spreading of liquid bioinks during 3D printing, and electrostatic interaction between the liquid bioinks and liquid granular baths is found to effectively prevent the diffusion of liquid bioinks. As an example, the printing of positively charged 5% w/v gelatin methacryloyl (GelMA) in a liquid granular bath prepared with negatively charged κ‐carrageenan is proved to be achievable. By LL3DBP, printing capacity is greatly advanced and bioinks with over 90% v/v cell can be printed, and printed structures with high‐cell‐proportion exhibit excellent bioactivity.
Super‐Tough, Non‐Swelling Zwitterionic Hydrogel Sensor Based on the Hofmeister Effect for Potential Motion Monitoring of Marine Animals
Authors: Ren Jiayuan , Chen Guoqi , Yang Hailong , Zheng Jingxia , Li Shengnan , Zhu Canjie , Yang Hua , Fu Jun 
Published: October 2024

AbstractHydrogel‐based electronic devices in aquatic environments have sparked widespread research interest. Nevertheless, the challenge of developing hydrogel electronics underwater has not been profoundly surmounted because of the fragility and swelling of hydrogels in aquatic environments. In this work, a zwitterionic double network hydrogel comprised of polyvinyl alcohol (PVA), poly(sulfobetaine methacrylate) (PSBMA), and sulfuric acid (H2SO4) demonstrates super‐tough and non‐swelling performance. The Hofmeister effect of H2SO4 and PSBMA induces the PVA chains to form numerous nanocrystalline domains, which serve as the primary physical crosslinking points and provide effective energy dissipation. H2SO4 induces a strong salting‐out effect to facilitate PVA crystallization and the formation of a dense and stable network structure that inhibits swelling. The resulting hydrogel exhibits an ultra‐high toughness of 4.61 MJ m−3, non‐swelling, and long‐term stability for up to a month in pure water and seawater. Based on this, a hydrogel‐based seawater strain sensor has been developed to monitor the underwater movements of marine animal models. Reliable and stable sensing performance ensures real‐time collection of underwater motion signals, despite the impacts of water flow and the interference of ions. This study provides a facile approach to designing super‐tough and non‐swelling hydrogels and further expands the application of underwater electronic devices.
High Efficiency n‐Type Doping of Organic Semiconductors by Cation Exchange
Authors: Zhao Xiaolei , Alsufyani Maryam , Tian Junfu , Lin Yuanbao , Jeong Sang Young , Woo Han Young , Yin Yi , McCulloch Iain 
Published: October 2024

AbstractAchieving efficient doping in n‐type conjugated polymers is crucial for their application in electronic devices. In this study, an n‐type doping method is developed based on cation exchange that maintains a high doping level while ensuring a high degree of structural order, leading to significantly improved electrical conductivity. By investigating various dopants and ionic liquids, it is discovered that the choice of dopant influences doping efficiency, while the selection of ionic liquid affects cation exchange efficiency. Through careful selection of suitable dopants and ionic liquids, High doping levels are achieved remarkably in a short period, resulting in the highest conductivity (nearly 1 × 10−2 S cm−¹) compared to other doping methods for poly{[N,N′‐bis(2‐octyldodecyl)‐naphthalene‐1,4,5,8‐bis(dicarboximide)‐2,6‐diyl]‐alt‐5,5′‐(2,2′‐bithiophene)} (N2200). The findings highlight the robustness and efficiency of cation exchange doping as an effective approach for achieving high‐quality n‐type doping in conjugated polymers, thereby opening new avenues for the development of advanced polymer‐based electronic devices.
Anisotropic Redox on Pristine Graphene
Authors: Saraf Akshat R. , Lim Jay Min , Saraf Ravi F. 
Published: October 2024

AbstractChemically modified graphene is an attractive electrode material for electrocatalysis, energy devices, and sensors, whereas pristine graphene is electrochemically passive. The remarkable anisotropic electrochemical nature of graphene is uncovered by π–π interaction, making pristine graphene more active than bare Au. The π–π stacking during redox reaction “dopes” the graphene, disrupting the passivating hydration layer, making it a facile electrochemical electrode. The structure during π–π stacking‐mediated redox of methylene blue (MB) is quantitatively measured by the differential reflectivity of a polarized laser on a ≈100 micron spot. The local redox reaction current varies over fourfold due to the orientation of the ≈10 micron size grains. The mosaic‐grain anisotropy on each spot shows local uniaxial orientation. The redox signal at the optimum orientation is over 2.5‐fold greater than that for bare Au on the same electrode. The redox signal is over fivefold greater at the edges of graphene compared bare Au. Remarkably, the π–π interaction increases chemical stability significantly, leading to negligible photo‐degradation at the approximate absorption wavelength of MB. The exclusive redox activity due to π–π interaction on pristine graphene adds to the toolbox of making exotic opto‐electrochemical electrode materials for electrocatalysis, sensing, and electronics.
Enhancing Chiroptoelectronic Activity in Chiral 2D Perovskites via Chiral–Achiral Cation Mixing
Authors: Li Hao , Sarker Pranab , Zhang Xiaoyu , Terban Maxwell W. , Ghose Sanjit , Dursun Ibrahim , Cotlet Mircea , Li Mingxing , Zhang Yugang , Xu Yuanze , Ramakrishnan Shripathi , Wei Tao , Lu Deyu , Yu Qiuming 
Published: October 2024

AbstractRational design of chiral two‐dimensional hybrid organic–inorganic perovskites is crucial to achieve chiroptoelecronic, spintronic, and ferroelectric applications. Here, an efficient way to manipulate the chiroptoelectronic activity of 2D lead iodide perovskites is reported by forming mixed chiral (R‐ or S‐methylbenzylammonium (R‐MBA+ or S‐MBA+)) and achiral (n‐butylammonium (nBA+)) cations in the organic layer. The strongest and flipped circular dichroism signals are observed in (R/S‐MBA0.5nBA0.5)2PbI4 films compared to (R/S‐MBA)2PbI4. Moreover, the (R/S‐MBA0.5nBA0.5)2PbI4 films exhibit pseudo‐symmetric, unchanged circularly polarized photoluminescence peak as temperature increases. First‐principles calculations reveal that mixed chiral–achiral cations enhance the asymmetric hydrogen‐bonding interaction between the organic and inorganic layers, causing more structural distortion, thus, larger spin‐polarized band‐splitting than pure chiral cations. Temperature‐dependent powder X‐ray diffraction and pair distribution function structure studies show the compressed intralayer lattice with enlarged interlayer spacing and increased local ordering. Overall, this work demonstrates a new method to tune chiral and chiroptoelectronic properties and reveals their atomic scale structural origins.
Highly Efficient and Bright Blue OLEDs via TSCT‐TADF Molecule Regulated by Indolo[3,2,1‐jk]Carbazole
Authors: Guo Haoqing , Tang Zhenyu , Gong Lefan , Tang Rong , Yang Shuang , Yu Wenjin , Liu Yueli , Wang Hantao , Ablikim Obolda , Qu Bo , Wei Jinbei , Chen Zhijian , Xiao Lixin 
Published: October 2024

AbstractThermally activated delayed fluorescence (TADF) materials with the through‐space charge transfer (TSCT) effects can provide a useful approach to efficiently utilize dark state triplet excitons through an efficient reverse intersystem crossing process. TSCT‐TADF emitters PCzoTrz‐ICz with small ∆EST values and high photoluminescence quantum yield is designed and synthesized using common acceptor triazine, donor 3,6‐diphenylcarbazole and Indolo[3,2,1‐jk]carbazole which is a rigid π‐conjugated group with high triplet state and high thermal stability. The doped‐organic light‐emitting diodes using PCzoTrz‐ICz as emitters exhibit high tolerance to host with different polarity and charge transport properties, and PCzoTrz‐ICz doped devices in 2,8‐bis(diphenylphosphoryl)dibenzofuran even realizes a maximum external quantum efficiency (EQEmax) of 32.5% and maximum current efficiency (CEmax) of 74.1 cd A−1, which is higher than EQEmax of 28.1% and CEmax of 64.8 cd A−1 of PCzoTrz. Moreover, PCzoTrz‐ICz can be used as highly efficient sensitizers for narrow band blue emitter of v‐DABNA, and achieves more than EQEmax of 33.3%, maximum luminance of 26,291 cd m−2, CEmax of 42.7 cd A−1 and blue index of 237 cd A−1 CIEy−1.
A Flexible Plasmonic Array with Both High Q‐Factor and Strong Near‐Field
Authors: Yang Yao , Ding Qi , Wei Yueyue , Du Yuanyuan , Wang Wei , Chen Ziqiu , Liu Bowen 
Published: October 2024

AbstractA higher quality (Q) factor and a stronger near field are two major advantages for surface plasmon resonance (SPR) applications based on high‐performance nanocavities. However, achieving a plasmonic structure that possesses both an ultra‐high Q‐factor and strong near‐field intensity has received relatively little attention. In this work, plasmonic arrays that offer a tunable Q‐factor, tunable near‐field intensity, and excellent uniformity over a centimeter‐scale area are fabricated on a flexible substrate. The flexibility and uniformity of this plasmonic array have been confirmed by its integration into stable optofluidic sensing systems. An in‐depth investigation into its sensitivity and figure of merit (FOM) highlights the superior performance of plasmonic sensing arrays that feature both an ultra‐high Q‐factor and a strong near‐field. This plasmonic array, together with its fabrication method, provides an optimized platform for a wide range of applications.
Gold‐Catalyzed Annulation Between 1‐[2‐(Dimethoxymethyl)phenyl]prop‐2‐yn‐1‐yl Acetates and α‐Diazo Esters or Anilines to Form Substituted Naphthoates and Indeno[1,2‐b]quinoline, Respectively
Authors: Suresh Kshirsagar Akshay , Liu Rai‐Shung 
Published: October 2024

AbstractThis work describes gold‐catalyzed annulations of 1‐(2‐(dimethoxymethyl)phenyl)‐1‐prop‐2‐yn‐1‐yl acetate substrates with α‐diazo esters and anilines, respectively yielding substituted naphthoates and indeno[1,2‐b]quinoline derivatives. Our mechanistic analysis indicates 1‐methoxy‐2‐carbonyl‐1H‐indenes as their common intermediates. In the formation of naphthoates, α‐diazo ester attacks at gold‐bound intermediate via an SN2 pathway to enable a allylic methoxy substitution. For indeno[1,2‐b]quinoline derivatives, there are two main reactions, including (i) a reversible formation between intermediate and a double amine addition product and (ii) an arylation reaction of intermediate. Species N‐(phenyl((2E)‐1‐(phenylimino)‐1,3‐dihydro‐2H‐inden‐2‐ylidene)methyl)aniline was converted to indeno[1,2‐b]quinoline in the presence of gold catalyst.
Exploring Protein Conformational Changes Using a Large‐Scale Biophysical Sampling Augmented Deep Learning Strategy
Authors: Hu Yao , Yang Hao , Li Mingwei , Zhong Zhicheng , Zhou Yongqi , Bai Fang , Wang Qian 
Published: October 2024

AbstractInspired by the success of deep learning in predicting static protein structures, researchers are now actively exploring other deep learning algorithms aimed at predicting the conformational changes of proteins. Currently, a major challenge in the development of such models lies in the limited training data characterizing different conformational transitions. To address this issue, molecular dynamics simulations is combined with enhanced sampling methods to create a large‐scale database. To this end, the study simulates the conformational changes of 2635 proteins featuring two known stable states, and collects the structural information along each transition pathway. Utilizing this database, a general deep learning model capable of predicting the transition pathway for a given protein is developed. The model exhibits general robustness across proteins with varying sequence lengths (ranging from 44 to 704 amino acids) and accommodates different types of conformational changes. Great agreement is shown between predictions and experimental data in several systems and successfully apply this model to identify a novel allosteric regulation in an important biological system, the human β‐cardiac myosin. These results demonstrate the effectiveness of the model in revealing the nature of protein conformational changes.
Remodeling Highly Fluorinated Electrolyte via Shielding Agent Regulation toward Practical Lithium Metal Batteries
Authors: Yang Yutong , Ma Shunchao , Yin Hongxing , Li Yanan , Chen Silin , Zhang Yu , Li Dan , Dong Feilong , Zhang Yue , Xie Haiming , Cong Lina 
Published: October 2024

AbstractHighly fluorinated electrolytes have proved effective in improving electrochemical stability of lithium metal batteries. However, excessive fluorination not only detrimentally impacts the electrolyte ionic conductivity, but also inevitably forms the over‐fluorinated interphases with sluggish ion diffusivity. Herein, a strategy on remodeling Li+ solvation structure in highly fluorinated electrolyte aided is proposed by fluorinated amide (FDMA), which denoted as “shielding agent”. Benefitting from FDMA's high donor number (DN) value (22.1), the Li+‐dipole (fluoroethylene carbonate (FEC) or trans‐4,5‐Difluoroethylenecarbonate (DFEC)) interaction is interrupted and the participation of FDMA in primary solvation sheath fructify the solid‐electrolyte interphase without scarifying the privilege of fluorinated electrolyte on interphase chemistry. Eventually, the optimal high‐fluorinated electrolyte (FDMA/DFEC + 1.0 mol L−1 LiTFSI) with this unique shielding effect displays high ionic conductivity and rapid Li+ desolvation behavior, enabling Li||LiNi0.6Co0.2Mn0.2O2 (Li||NCM622) to achieve an ultralong cycle‐life of 2000 cycles at 1C with 84.7% capacity retention. Even under extreme conditions (NCM622: 10 mg cm−2; electrolyte: 20 µL; Li: 50 µm), the Li||NCM622 displays excellent electrochemical performance. Additionally, 447 Wh kg−1 Li||LiNi0.8Co0.1Mn0.1O2 (Li||NCM811) pouch cells have been successfully fabricated and demonstrate an exceptional cycle‐life over 150 cycles. The proposed “shielding” strategy to modulate the solvation structure paves the way for developing practical LMBs with fluorinated electrolytes.
Sirt6 Mono‐ADP‐Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission
Authors: Zhang Wei , Bai Lei , Xu Wentao , Liu Jun , Chen Yi , Lin Weiqiang , Lu Huasong , Wang Binwei , Luo Benyan , Peng Guoping , Zhang Kejing , Shen Chengyong 
Published: October 2024

AbstractThe degeneration of the neuromuscular junction (NMJ) and the decline in motor function are common features of aging, but the underlying mechanisms have remained largely unclear. This study reveals that Sirt6 is reduced in aged mouse muscles. Ablation of Sirt6 in skeletal muscle causes a reduction of Dystrophin levels, resulting in premature NMJ degeneration, compromised neuromuscular transmission, and a deterioration in motor performance. Mechanistic studies show that Sirt6 negatively regulates the stability of the Dystrophin repressor YY1 (Yin Yang 1). Specifically, Sirt6 mono‐ADP‐ribosylates YY1, causing its disassociation from the Dystrophin promoter and allowing YY1 to bind to the SMURF2 E3 ligase, leading to its degradation. Importantly, supplementation with nicotinamide mononucleotide (NMN) enhances the mono‐ADP‐ribosylation of YY1 and effectively delays NMJ degeneration and the decline in motor function in elderly mice. These findings provide valuable insights into the intricate mechanisms underlying NMJ degeneration during aging. Targeting Sirt6 could be a potential therapeutic approach to mitigate the detrimental effects on NMJ degeneration and improve motor function in the elderly population.