bluuebunny/crossref_metadata_2025_split huggingface dataset:
Music-induced analgesia in chronic pain conditions: a systematic review and meta-analysis
Authors: Garza-Villarreal Eduardo A. , Pando Victor , Vuust Peter , Parsons Christine 
Published: February 2017

AbstractMusic is increasingly used as an adjuvant for chronic pain management as it is not invasive, inexpensive, and patients usually report positive experiences with it. However, little is known about its clinical efficacy in chronic pain patients. In this systematic review and meta-analysis, we investigated randomized controlled trials (RCTs) of adult patients that reported any type of music intervention for chronic pain, chosen by the researcher or patient, lasting for any duration. Searches were performed using PsycINFO, Scopus and PubMed for RTCs published until the end of May 2016. The primary outcome was reduction in self-reported pain using a standardized pain measurement instrument reported post-intervention. The secondary outcomes were: quality of life measures, depression and anxiety measures, among others. The study was pre-registered with PROSPERO (CRD42016039837) and the meta-analysis was done using RevMan. We identified 768 titles and abstracts, and we included 14 RTCs that fulfilled our criteria. The sample size of the studies varied between 25 and 200 participants. We found that music reduced chronic pain, and depression, with higher effect size on pain and depression. We also found music had a higher effect when the participant chose the music in contrast with researcher-chosen music. The sample size of RCTs was small and sometimes with different outcome measures. Our analysis suggests that music may be beneficial as an adjuvant for chronic pain patients, as it reduces self-reported pain and its common co-morbidities. Importantly, the analgesic effect of music appears higher with self-chosen over researcher-chosen music.
Metaviz: interactive statistical and visual analysis of metagenomic data
Authors: Wagner Justin , Chelaru Florin , Kancherla Jayaram , Paulson Joseph N. , Felix Victor , Mahurkar Anup , Bravo Héctor Corrada 
Published: February 2017

AbstractAlong with the survey techniques of 16S rRNA amplicon and whole-metagenome shotgun sequencing, an array of tools exists for clustering, taxonomic annotation, normalization, and statistical analysis of microbiome sequencing results. Integrative and interactive visualization that enables researchers to perform exploratory analysis in this feature rich hierarchical data is an area of need. In this work, we present Metaviz, a web browser-based tool for interactive exploratory metagenomic data analysis. Metaviz can visualize abundance data served from an R session or a Python web service that queries a graph database. As metagenomic sequencing features have a hierarchy, we designed a novel navigation mechanism to explore this feature space. We visualize abundance counts with heatmaps and stacked bar plots that are dynamically updated as a user selects taxonomic features to inspect. Metaviz also supports common data exploration techniques, including PCA scatter plots to interpret variability in the dataset and alpha diversity boxplots for examining ecological community composition. The Metaviz application and documentation is hosted athttp://www.metaviz.org.
p53 binding sites in normal and cancer cells are characterized by distinct chromatin context
Authors: Bao Feifei , LoVerso Peter R. , Fisk Jeffrey N. , Zhurkin Victor B. , Cui Feng 
Published: February 2017

AbstractThe tumor suppressor protein p53 interacts with DNA in a sequence-dependent manner. Thousands of p53 binding sites have been mapped genome-wide in normal and cancer cells. However, the way p53 selectively binds its cognate sites in different types of cells is not fully understood. Here, we performed a comprehensive analysis of 25 published p53 cistromes and identified 3,551 and 6,039 ‘high-confidence’ binding sites in normal and cancer cells, respectively. Our analysis revealed two distinct epigenetic features underlying p53-DNA interactionsin vivo. First, p53 binding sites are associated with transcriptionally active histone marks (H3K4me3 and H3K36me3) in normal-cell chromatin, but with repressive histone marks (H3K27me3) in cancer-cell chromatin. Second, p53 binding sites in cancer cells are characterized by a lower level of DNA methylation than their counterparts in normal cells, probably related to global hypomethylation in cancers. Intriguingly, regardless of the cell type, p53 sites are highly enriched in the endogenous retroviral elements of the ERV1 family, highlighting the importance of this repeat family in shaping the transcriptional network of p53. Moreover, the p53 sites exhibit an unusual combination of chromatin patterns: high nucleosome occupancy and, at the same time, high sensitivity to DNase I. Our results suggest that p53 can access its target sites in a chromatin environment that is non-permissive to most DNA-binding transcription factors, which may allow p53 to act as a pioneer transcription factor in the context of chromatin.
Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities
Authors: Walker Venexia M , Smith George Davey , Davies Neil M , Martin Richard M 
Published: February 2017

ABSTRACTIdentification of unintended drug effects, specifically drug repurposing opportunities and adverse drug events, maximizes the benefit of a drug and protects the health of patients. However, current observational research methods are subject to several biases. These include confounding by indication, reverse causality, and missing data. We propose that Mendelian randomization (MR) offers a novel approach for the prediction of unintended drug effects. In particular, we advocate the synthesis of evidence from this method and other approaches, in the spirit of triangulation, to improve causal inferences concerning drug effects. MR overcomes some of the limitations associated with the existing methods in this field. Furthermore, it can be applied either pre- or post-approval of the drug and could therefore prevent the potentially harmful exposure of patients in clinical trials and beyond. The potential of MR as a pharmacovigilance and drug repurposing tool is yet to be realized and could both help prevent adverse drug events and identify novel indications for existing drugs in the future.
Ambiguity of financial environmental information
Authors: Laine Matias , Järvinen Janne T. , Hyvönen Timo , Kantola Hannele 
Published: February 2017

Purpose
Voluntary corporate social responsibility reporting has developed into an everyday activity for many commercial organizations, and scholarly interest in these practices continues to increase. This paper focusses on one subset of these disclosures, namely the figures relating to environmental expenditures and investments published by various organizations. The purpose of this paper is to provide insights into the nature, role and significance of such financial environmental information. Despite their seeming accuracy and preciseness, little is known about how such financial environmental information is constructed and subsequently used in organizational settings.

Design/methodology/approach
The paper is based on a qualitative case study focussing on a Finnish energy company. The authors build the investigation primarily on 26 semi-structured interviews with employees at all organizational levels, which the authors supplement with various documentary sources. The interpretation draws on the notion of loose coupling, which the authors use as a method theory to provide a better understanding of this complex organizational practice.

Findings
The authors highlight the ambiguous and imprecise nature of the outwardly accurate figures provided by the company. The authors argue that disclosed financial environmental information is only loosely coupled with various dimensions, including the organization’s actual activities, its environmental impacts and organizational decision making.

Originality/value
The findings contrast with those of some prior research, which has considered financial environmental information highly valuable. As for broader implications, the paper discusses the accuracy of public records based on such ambiguous organizational figures.
The processes of inclusion and exclusion
Authors: Hayes Colleen , Jacobs Kerry 
Published: February 2017

PurposeThe purpose of this paper is to revisit the issue of the entry of women into the Anglo-Australian accounting profession in the Second World War and provide insights on the role that gender, class, and ethnicity played in mediating women’s relations with the accounting profession in that period.Design/methodology/approachThe study is based on the narratives of three women from diverse social backgrounds who entered the Anglo-Australian profession during this period.FindingsThe analysis indicates that while participants had the mindset needed for accounting work, the more removed the individual’s perceived social identity was from her perception of the dominant British, white, middle-class ideology of the profession, the less likely she was to embrace the opportunity to join the accounting profession. The distance was anchored in social (ethnicity and class) and historical forces. The study also finds that the appropriation of education and credentials ameliorated disadvantages accruing from gender and working-class status.Practical implicationsThis study has implications for our understanding of the accounting profession and what is required to reduce the risks of marginalization in a contemporary setting.Originality/valueThe study provides a richer understanding of how class and ethnicity shape the female experience differently. The results also demonstrate that in times of social change, the processes of inclusion and exclusion are not confined to the deliberations of the accounting profession but also the individual. Whether the women valued accounting as an occupation depended on whether or not if offered them the freedom to achieve what they valued most. At the same time, however, the freedom to realize what they valued most was a function of class and ethnicity. Finally, the results demonstrate the capacity of unique experience to shape the perceptions, aspirations and actions of women.
Personal and relational empowerment: a framework for family recovery
Authors: Buckley-Walker Kellie , Crowe Trevor P. , Caputi Peter 
Published: February 2017

Purpose
Caring for a person with a substance use disorder (SUD) and/or mental health disorder (MHD) represents a significant burden for family members. The features of “carers/family members” experiences reflect trauma signatures. Consequently, working through this trauma for carers corresponds with psychological recovery, empowerment processes and intrapersonal/interpersonal needs. The purpose of this paper is to outline a framework called the “personal and relational empowerment (PRE)” framework which enables family support practitioners to help family members to be able to take control of their own lives, develop meaningful relationships and live purposeful and fulfilling lives, regardless of whether the person with the SUD and/or MHD is in recovery or not.

Design/methodology/approach
This paper critically reviews existing frameworks for carer recovery, through a systematic literature search, and proposes a “PRE” alternative to redress the shortfalls in these existing frameworks.

Findings
The PRE framework takes a multi-level needs-based approach to understand carer recovery. This framework links the concepts – psychological recovery, empowerment processes and intrapersonal/interpersonal needs.

Practical implications
The PRE framework recognises the importance of recovery support practitioners being able to balance the immediate carer crisis intervention needs responses with personal growth and well-being supporting interventions.

Originality/value
The PRE framework of family recovery attempts to answer the need to broaden the focus on the family journey to better reflect the principles and practices of contemporary SUD and/or MHD recovery-based support.
First-person experiences of recovery in co-occurring mental health and substance use conditions
Authors: Brekke Eva , Lien Lars , Davidson Larry , Biong Stian 
Published: February 2017

Purpose
The purpose of this paper is to explore and describe experiences of recovery among people with co-occurring mental health and substance use conditions (co-occurring conditions) in a rural community in Norway.

Design/methodology/approach
In-depth individual interviews with eight persons with co-occurring conditions were conducted, audiotaped, transcribed and analysed using a phenomenological approach. This study is part of a research project investigating recovery orientation of services in a Norwegian district.

Findings
The analysis yielded four dimensions of recovery: feeling useful and accepted; coming to love oneself; mastering life; and emerging as a person. Insecure and inadequate housing and limited solutions to financial problems were described as major obstacles to recovery.

Research limitations/implications
Further research into the facilitation of recovery as defined by persons with concurrent disorders is needed, particularly regarding the facilitation of community participation.

Practical implications
This study supports an increased focus on societal and community factors in promoting recovery for persons with co-occurring conditions, as well as service designs that allow for an integration of social services and health care, and for collaboration among services.

Social implications
The results suggest that the community can aid recovery by accepting persons with co-occurring conditions as fellow citizens and welcoming their contributions.

Originality/value
The paper provides an enhanced understanding of how persons with co-occurring conditions may experience recovery.
The effect of audit fees pressure on audit quality during the sanctions in Iran
Authors: Salehi Mahdi , Jafarzadeh Azadeh , Nourbakhshhosseiny Zeinab 
Published: February 2017

Purpose
The current study aims to investigate the amount of downward pressure on audit fees and its effect on audit quality.

Design/methodology/approach
The research population includes 104 listed companies on the Tehran Stock Exchange. In this study, at first, the audit fees pressure was measured; then, by comparing it with actual audit fees, the pressure on audit costs was calculated. Finally, the hypotheses were tested using logistic regression.

Findings
The results of models and hypotheses show that, as expected, during the intensification of sanctions (i.e. during 2010), compared with other years, business entities have exerted more pressure to reduce audit fees; moreover, there is a positive significant relationship between fees pressure and the rate of misstatement (reverse audit quality criterion) at 10 per cent error level during 2010, whereas in years before and after 2010, there is no significant relationship between audit fees pressure and audit quality.

Originality/value
The conducted studies in Iran so far have investigated time pressures imposed on auditors. In this study, the audit fees pressure is investigated.
Proximity as determinant of business cooperation for technological and non-technological innovations: a study of an agribusiness cluster
Authors: Geldes Cristian , Heredia Jorge , Felzensztein Christian , Mora Marcos 
Published: February 2017

Purpose
This paper aims to use the proximity approach of economic geography with its spatial dimension (geographic) and their non-spatial dimensions (social, institutional, cognitive and organizational) to shed light on the determinants of business cooperation with other organizations. It is also examined whetherthis cooperation is a determining factor for business innovation (innovation networks), drawing a distinction between technological and non-technological innovations.

Design/methodology/approach
The study has a quantitative approach; it analyzes the case of 312 companies in a cluster of agribusinesses in an emerging economy (Chile). The proposal model and its interrelations are tested with exploratory factor analysis, confirmatory factor analysis and structural equation modeling.

Findings
The results show that cognitive-organizational proximity is a positive determinant of business cooperation with other organizations, whereas social and institutional proximity are negative determinants. It is also established that business cooperation is a positive determinant of business innovation. It is more relevant in the case of technological innovation unlike non-technological innovations. In addition, it is noted that business cooperation levels are lower in micro-enterprises, a result that differs from developed countries.

Practical implications
For business managers, it is best to cooperate with companies that are similar in terms of cognitive and organizational levels for innovation. At the same time, it is necessary develop strategies to reduce the social and institutional barriers to cooperation, especially in the agribusiness sector.

Originality/value
The contributions of the study are as follows: an in-depth quantitative examination of the relationships of various non-spatial proximities as determinants of business cooperation; an analysis of whether business cooperation with other organizations is a determining factor for business innovation, distinguishing between technological and non-technological innovation; and testing these relationships in the context of agribusiness in an emerging economy such as Chile’s because most of studies are related to high-tech sector and developed economies.
Buyer versus salesperson expectations for an initial B2B sales meeting
Authors: Kaski Timo Arvid , Hautamaki Pia , Pullins Ellen Bolman , Kock Heidi 
Published: February 2017

Purpose
The purpose of this paper to explore the value creation expectations of salespeople and buyers for initial sales meetings and to investigate how such expectations align.

Design/methodology/approach
The authors applied expectancy disconfirmation theory and conducted a qualitative study among 12 B2B service salespeople and 12 buyers. The data includes 46 in-depth interviews collected during 2 separate interview rounds.

Findings
The authors discovered that buyers’ and sellers’ expectations differ and that buyers’ expectations are not reasonably satisfied. Buyers expect more business acumen, innovativeness, future orientation, long-term relationships and responsiveness to their specific situation from sellers. As salespeople´s salespeople´s expectations to create value for customers primarily stem from the solutions they sell as well as from their personal skills and behavior, there is need for sellers to focus on the gaps indicated in this study.

Research limitations/implications
The paper introduces expectancy disconfirmation theory to the B2B buyer-seller literature.

Practical implications
Identifying where expectations are being met and where they are being negatively disconfirmed can assist in hiring and training salespeople who are better able to meet, or exceed, buyer expectations.

Originality/value
The authors believe that these findings can benefit sales organizations in how they create value with new customers and how salespeople can align their actions with customers more effectively.
Promoting or protecting my brand: the identity-expression and fear-of-imitation conflict
Authors: Thomas Veronica L. , Saenger Christina 
Published: February 2017

Purpose
The purpose of this paper is to examine the conflict between consumers’ need to spread word-of-mouth about brands to express identity and the motivation to protect identity-linked brands from outside adoption that could dilute the brand’s symbolic associations. Current studies examine the interactive effects of self-brand connection (SBC) and consumer need for uniqueness (cNFU) on intentions to engage in brand-promoting and brand-protecting word-of-mouth behavior to in-group and out-group recipients.

Design/methodology/approach
Experimental scenario stimulus-based survey research was conducted, including scales measuring intentions to engage in promoting and protecting word-of-mouth, SBC and cNFU. Data for four studies were collected via online surveys and were analyzed using Hayes’ (2013) PROCESS macro and the Johnson–Neyman technique in SPSS 21.0.

Findings
The results of four studies demonstrate that the interaction between SBC and cNFU tempers intentions to engage in brand-promoting word-of-mouth and amplifies intentions to engage in brand-protecting word-of-mouth, when the recipient of the word-of-mouth communication is an out-group, but not an in-group, member.

Originality/value
This work exposes the conflict between identity-expression and fear-of-imitation by demonstrating that consumers’ tempered intentions to spread brand-promoting word-of-mouth and amplified intentions to spread brand-protective word-of-mouth are deliberate strategic mechanisms used to protect brand meaning. In doing so, this research exposes cNFU as a factor that influences self-brand-connected consumers to engage in a negative brand behavior and qualifies work in identity-expressive word-of-mouth that suggests that self-presentational concerns lead consumers to avoid spreading negatively valenced word-of-mouth about identity-linked brands.
Role of brand names and product types on bicultural consumers’ purchase intentions
Authors: Moriuchi Emi , Jackson Paul R. 
Published: February 2017

Purpose
The purpose of this study is to examine the role of brand names and product types on bicultural’s purchasing intention. In cross-cultural marketing, a current popular position among bicultural consumer advocates that brand name that has a foreign character denotes that when an unknown brand is present, and if the unknown brand is a hedonic product, then a foreign character that has a long-standing history of delivery quality products should be mandatory.

Design/methodology/approach
Through a multidisciplinary literature review, qualitatively supported differences in bicultural consumers from a majority-minority status are reviewed and formulated as hypotheses, and a survey is used to collect quantitative data from a stratified random sample.

Findings
A 2 (cultural identity vs felt ethnicity) × 2 (English brand name vs Japanese brand name) factorial experiment, which tested this contention, revealed that, although consumers are considered biculturals, they will be more inclined to perceive products to be of higher quality when the product is written in Japanese than in English. Furthermore, the result shows that felt ethnicity has a significant impact on attitude toward brand names, whereas bicultural’s cultural identity does not. However, on the other hand, cultural identity has a significant impact on the product type considered, whereas felt ethnicity does not.

Research limitations/implications
As a starting point for understanding the bicultural consumer from a majority-minority perspective, this study is subject to exploratory research limitations.

Practical implications
The result suggests that when developing ads, managers should take into account the effect of language characters has on their target audience’s ethnicity. As it is common for ads to consist of written language, colors, images and messages, managers should not just concentrate on one, rather should consider how all these factors can come together and create a favorable ad.

Originality/value
As the number of immigrants increase in the USA, the notion of considering what a melting pot is has reached another level. Predicted by the US census, in the year 2050, the minority population will take over the mainstream population, resulting in a majority-minority status for these minority individuals. Businesses will then have to redesign their strategy in marketing to this new market segment and not fall victim to these new challenges. They can turn around and leverage them as marketplace opportunities. This study provides some early insights that can help marketers strategically and creatively think of leverage such opportunities.