bluuebunny/crossref_metadata_2025_split huggingface dataset:
A twin-driven analysis on early aging biomarkers and associations with sitting-time and physical activity
Authors: Bruellman Ryan , Pahlen Shandell , Ellingson Jarrod M. , Corley Robin P. , Wadsworth Sally J. , Reynolds Chandra A. 
Published: September 2024

Background
Current physical activity guidelines may be insufficient to address health consequences in a world increasing in sedentary behavior. Physical activity is a key lifestyle factor to promote healthy aging, but few studies examine activity in conjunction with sitting. We examine how activity intensity and sitting behavior influence health and the extent to which physical activity might counter sitting.

Methods
We analyzed data from the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife) in adults aged 28–49 years (M = 33.16, SD = 4.93). We fit a linear mixed-effect model for body mass index (BMI) and total cholesterol/high-density lipoprotein ratio (TC/HDL). Leveraging the co-twin control approach, we explore the trade-off between sitting and physical activity.

Results
Across established adulthood, TC/HDL and BMI demonstrated increasing age trends with prolonged sitting and vigorous activity inversely associated. Moreover, after considering sitting time, we found an age-equivalent benefit of vigorous exercise where those performing 30 minutes daily had expected TC/HDL and BMI estimates that mirrored sedentary individuals 5 and 10 years younger, respectively. Co-twin control analysis suggests partial exposure effects for TC/HDL, indicating greater vigorous activity may counter sitting-health effects but with diminishing returns.

Conclusions
Our findings support the counteracting influence of prolonged sitting and physical activity on indicators of cardiovascular and metabolic health. A compensating role of vigorous activity on sitting health links is indicated while reducing sitting time appears paramount. Public health initiatives should consider sitting and vigorous activity in tandem in guidelines to promote health maintenance and combat accelerated aging.
A decline in tuberculosis diagnosis, treatment initiation and success during the COVID-19 pandemic, using routine health data in Cape Town, South Africa
Authors: Jennings Karen , Lembani Martina , Hesseling Anneke C. , Mbula Nyameka , Mohr-Holland Erika , Mudaly Vanessa , Smith Mariette , Osman Muhammad , Meehan Sue-Ann 
Published: September 2024

Background
Coronavirus disease (COVID-19) negatively impacted tuberculosis (TB) programs which were already struggling to meet End-TB targets globally. We aimed to quantify and compare diagnosis, treatment initiation, treatment success, and losses along this TB care cascade for drug-susceptible TB in Cape Town, South Africa, prior to and during COVID-19.

Methods
This observational study used routine TB data within two predefined cohorts: pre-COVID-19 (1 October 2018–30 September 2019) and during-COVID-19 (1 April 2020–31 March 2021). The numbers of people diagnosed, treated for TB and successfully treated were received from the Western Cape Provincial Health Data Centre. Pre and post treatment loss to follow up and cascade success rates (proportion of individuals diagnosed with an outcome of treatment success) were calculated and compared across cohorts, disaggregated by sex, age, HIV status, TB treatment history and mode of diagnosis.

Results
There were 27,481 and 19,800 individuals diagnosed with drug-susceptible TB in the pre- and during-COVID-19 cohorts respectively, a relative reduction of 28% (95% CI [27.4% - 28.5%]). Initial loss to follow up increased from 13.4% to 15.2% (p<0.001), while post treatment loss increased from 25.2% to 26.1% (p < 0.033). The overall cascade success rate dropped by 2.1%, from 64.8% to 62.7% (p< 0.001). Pre- and during-COVID-19 cascade success rates were negatively associated with living with HIV and having recurrent TB.

Conclusions
An already poorly performing TB program in Cape Town was negatively impacted by the COVID-19 pandemic. There was a substantial reduction in the number of individuals diagnosed with drug-susceptible. Increases in pre-and post-treatment losses resulted in a decline in TB cascade success rates. Strengthened implementation of TB recovery plans is vital, as health services now face an even greater gap between achievements and targets and will need to become more resilient to possible future public health disruptions.
Fashion Education: The Systemic Revolution, Ben Barry and Deborah A. Christel (eds) (2023)
Authors: Becker Payton 
Published: September 2024

Review of: Fashion Education: The Systemic Revolution, Ben Barry and Deborah A. Christel (eds) (2023)
Bristol: Intellect, 352 pp.,
ISBN 978-1-78938-680-6, p/bk, $47.95
Environmental Management Accounting: A Tool for Better Management Practice
Authors: Kassim Che Ku Hisam Che Ku , Ariffin Avylin Roziana Mohd , Muhmad Siti Nasuha 
Published: September 2024

Over the years, there has been a growing emphasis among organisations on the need to address environmental issues and develop management practices and tools that are useful in improving environmental performance of the organisations. The deficiency of conventional accounting practices has spurred the infusion of environmental management accounting (EMA) and its adoption has been promoted at international, national and local government levels. The main purpose of this paper is to provide a general discussion on pertinent characteristics of EMA including its supporting tools to enhance its applicability and potential benefits that could be derived from its adoption. The discussion adds to the existing literature and provides a platform for future research intending to examine the extent of EMA development in an organisation.
The outcome of haematopoietic stem cell transplantation in a patient with STAT1 gain-of-function: a case report
Authors: Al Shaqaq Azhar , Roifman Chaim M. 
Published: September 2024

Background: The human signal transducer and activator of transcription 1 (STAT1) is a latent cytoplasmic transcription factor and one of seven members of the STAT family. Autosomal dominant (AD) STAT1 gain-of-function (GOF), characterized by enhanced phosphorylation of the tyrosine-701 residue and STAT1 activation, is commonly associated with chronic mucocutaneous candidiasis (CMCC), immunodeficiency, aneurysms, malignancies, and autoimmune phenomena. The best management strategies for patients with STAT1 GOF remain unclear. Typically, the standard care includes supportive treatments such as antimicrobial prophylaxis, either alone or combined with immunoglobulin replacement therapy. Biological therapies such as JAK inhibitors have been shown to alleviate symptoms of infection and autoimmune disorders in patients with STAT1 GOF mutations. However, there is a lack of long-term outcome data for JAK inhibition. Hematopoietic stem cell transplantation (HSCT) is an alternative treatment option for a subset who experience a persistent disease course despite conventional therapy. However, the effectiveness of HSCT for this condition is not yet well established. Methods: Our patient’s medical records were analyzed retrospectively, including her medical history. Results: We present the outcome of HSCT performed on a 27-year-old female with STAT1 GOF, conducted as a treatment for acute myeloid leukemia (AML). Conclusion: HSCT may serve as an alternative and potentially curative treatment for certain STAT1 GOF patients with progressive, life-threatening conditions that do not respond to conventional therapies. Additional research is needed to improve the management of these patients. Statement of Novelty: We present a novel case study of HSCT as a treatment for AML in a 27-year-old patient with STAT1 GOF, highlighting the potential for curative outcomes in progressive, life-threatening conditions unresponsive to conventional therapies. This case contributes to the limited body of evidence supporting the efficacy and challenges of HSCT in STAT1 GOF patients.
Fanconi syndrome and renal tubular necrosis in patients following ingestion of potentially contaminated red yeast rice supplement: Two case reports
Authors: Yoshikawa Yoshiyuki , Anzai Hitoshi , Odajima Kohei , Asakawa Shinichiro , Arai Shigeyuki , Yamazaki Osamu , Tamura Yoshifuru , Ohashi Ryuji , Shibata Shigeru , Fujigaki Yoshihide 
Published: September 2024

AbstractWe present two cases of middle‐aged men who developed Fanconi syndrome and renal dysfunction after consuming “foods with functional claims (FFC)” containing red yeast rice. In the first case, the patient had consumed an FFC for 1 year and another FFC suspected to have contained nephrotoxin for 3 weeks; kidney biopsy performed during the acute phase of renal injury showed severe acute tubular necrosis and tubular cell regeneration. He achieved near‐complete recovery 40 days after the FFC was discontinued. In the second case, the patient had consumed FFC for 4 years and stopped 70 days prior to presentation; kidney biopsy revealed significant tubular recovery, persistent tubular injuries, and interstitial fibrosis. Although the manifestations of Fanconi syndrome subsided, mild renal dysfunction persisted. These cases suggest that FFC with nephrotoxins may induce Fanconi syndrome owing to acute tubular necrosis. Recovery is possible after discontinuing the FFC; while short‐term ingestion of FFC allows for tubular regeneration, its long‐term ingestion may cause irreversible damage and lead to chronic kidney disease. Long‐term follow‐up is crucial for preventing further renal deterioration.
Cardiac dysfunction in dialysing adults with end‐stage kidney disease is associated with exercise intolerance: A pilot observational study
Authors: Antoun Joe , Shepherd Anthony I. , Corbett Jo , Sangala Nicholas C. , Lewis Robert J. , Lane Emma , Saynor Zoe L. 
Published: September 2024

AbstractPeople with end‐stage kidney disease (ESKD) often exhibit impaired cardiac structure and function, which may contribute to poor exercise capacity. This study used multimodal exercise testing to investigate the central and peripheral mechanisms of exercise limitation in adults with ESKD, also comparing in‐centre hemodialysis (ICHD) to home hemodialysis (HHD). Seventeen adults (55.5 ± 14.5 years; n = 14 male; n = 12 HHD) participated. Resting cardiac examinations, followed by submaximal cycling cardiopulmonary exercise testing (CPET) and functional exercise testing, revealed cardiac structural abnormalities (increased left ventricular mass) and cardiac injury. Aerobic fitness in adults with ESKD was low, with pulmonary oxygen uptake (V̇O2) at the gas exchange threshold (GET) occuring at 39 ± 8% predicted V̇O2peak. O2 pulse, an estimate of stroke volume (SV), was higher in HHD at rest (p = 0.05, ES = 0.58) and during unloaded cycling (p = 0.05, ES = 0.58) compared to ICHD. However, thoracic bioreactance derived SV at the GET was significantly higher in adults receiving ICHD versus HHD (p = 0.01, ES = 0.74). In adults with ESKD, cardiac output was positively associated with V̇O2 at the GET (r = 0.61, p = 0.04). This study highlights prevalent exercise dysfunction in adults with ESKD undergoing dialysis, with potential distinct differences between in‐centre and home hemodialysis, mechanistically linked to underlying cardiac abnormalities.
The (Social) Tasks of Business Tax Research and the Binding Effect of the Statutory Tax Burden Decision
Authors: Kollruss Thomas 
Published: September 2024

Abstract
Against the background of taxation, this article critically examines Schmiel’s commentary “Why tax planning without considering societal interests is unfounded” (https://doi.org/10.1515/ael-2021-0115) and points out the overarching context. This rejoinder argues that the task and the object of my business tax research article, namely to analyse value-neutral tax regulations, in this case the ATAD CFC taxation regulations, with regard to their effectiveness and their achievement of objectives and to derive practical consequences for future tax legislation and further legislative development of the existing tax regulations. Through such an analysis, deficits in the effectiveness of the current tax regulations are revealed at an early stage and the legislator can react before tax losses occur (early information function). This is precisely how social interests are pursued and answered. Moreover, this rejoinder argues that in the area of taxation, it is exclusively the tax legislator who determines in the democratic legislative process which objectives, steering effects and (tax) burden effects it pursues with a norm and to what extent it pursues these objectives. The extent to which the legislator pursues societal or social interests with a tax norm is up to the legislator. This is the so-called assessment prerogative, i.e. the prerogative of the legislature (norm-setter) to decide on the appropriateness and necessity of a particular statutory regulation to achieve a legitimate goal in an ultimately binding manner, taking into account the interests of the state as a whole. This rejoinder rejects’ Schmiel’s claim to use critical rationalism as a methodological framework for research on tax law. From my viewpoint, only the objective will of the legislator (objective intention of the legislator, aim of the law, principle of legality) and the relevant legal principles and methodology as well as the methods of business tax research are relevant when it comes to examining the scope of application of current tax law provisions and their effectiveness, here the CFC taxation rules. Alternative theories such as critical rationalism, a philosophical view, appear to be too vague to ensure legal certainty and appropriate taxation.
Intuitions as Arrows. Moral Knowledge and Kantian Schematism
Authors: Graziano Mario 
Published: September 2024

Abstract
Ethical intuitionism traces its roots back to the early eighteenth century in the field of ethics. Despite apparent distinctions, intuitionism, especially in its recent development by Huemer, bears a striking resemblance to robust versions of rationalist foundationalism. In this paper, we will argue against the perspective of robust intuitionism. Furthermore, we commit to reviewing what theorists operating within the field of study known as Dual Process Theory hypothesize about intuition. Nonetheless, we do not claim that the origin of our moral beliefs is unreliable or discreditable. On the contrary, we entertain the prospect of reviving intuitionistic themes by leveraging the concept of a Kantian scheme.
Harvest date and salicylic acid impact on peanut (Arachis hypogaeaL.) properties under different humidity conditions
Authors: Charvadeh Mehrab Mehri , Rad Marefat Mostafavi , Zakerin Hamid Reza , Sayfzadeh Saeed , Valadabady Seyed Alireza 
Published: September 2024

AbstractThis study was conducted to investigate the effects of salicylic acid and harvest date on the yield and biochemical and physiological characteristics of peanuts in different humidity conditions, which is the novelty of this research. For this purpose, a split-plot factorial design during the 2018 and 2019 cropping seasons was conducted based on a randomized complete block design with three replications at the experimental field of the Agricultural and Natural Resources Research and Education Center of Guilan Province, Astara, Iran. Humidity regimes included rain-fed conditions (no irrigation), irrigation at the 10% flowering stage, 10% pod formation stage, and 10% flowering stage +10% pod formation stage in the main plots, and three salicylic acid levels (100, 200, and 300 µmol/l), and harvest dates (August 22, September 6, and September 21), were placed in subplots. Drought stress reduced the Chlorophyll Index, relative water content, seed, and pod yield but increased proline, Antioxidant enzyme activity, soluble sugar content, and H2O2content. Conversely, Supplementary irrigation decreased proline, antioxidant enzyme activity, soluble sugar content, and H2O2content, which increased the Chlorophyll Index, relative water content, seed, and pod yield. Also, salicylic acid foliar application enhanced guaiacol peroxidase, polyphenol oxidase, and ascorbate peroxidase antioxidant enzyme activity, mitigating the undesirable impacts of water deficiency. The maximum pod and seed production was obtained in all humidity conditions with 300 µmol/l salicylic acid. Under Humidity stress conditions, if water resources are available, two supplementary irrigations at 10% flowering and 10% pod formation stage are recommended. Also, for humid climates such as Astara and similar regions, in terms of climate, with limited rainfall in June and July (rainfall less than 10 mm during flowering and podding stages), one supplementary irrigation at 10% pod formation stage is recommended.
¿Cómo piensan los empresarios y trabajadores del mar argentino sobre la captura incidental y el descarte pesquero?
Authors: Schulze María Soledad , Góngora María Eva 
Published: September 2024

[Introduction]: Bycatch and discards are a socio-environmental concern that threatens the sustainability of marine life and fishing grounds. Approaches to this problem have focused on biological and/or ecological aspects. We considered it necessary to explore the problem from the social dimension and for this purpose we explored social representations. [Objective]: The aim of this study is to explore the social representations of bycatch and discards in a group of businessmen and workers in the capture stage of the Argentine industrial fishing activity. We ask how they evaluate bycatch and fishing discards, what are their causes and if they observe possible solutions. [Methodology]: Within the framework of a project of the Federal Fishing Council, we conducted focus groups with businessmen, business chambers, SOMU workers and captains of the industrial fishing activity. [Results]: The results of the focus groups conducted in 2021 reveal three main causes of this problem. First, the lack of reliable data on actual discard levels raises concerns about sustainability and overfishing. Second, the low utilization of selectivity devices is attributed to their operational inefficiency and possible labour barriers. Finally, economic and organizational pressures, such as company profitability and workers' salaries, justify the discard of non-target species, exacerbating the problem. [Conclusions]: The work contributes to an understanding of the main reasons for bycatch and discards, which is essential to advance solutions. We understand that solutions are not simple and involve a sincere debate among stakeholders.
Three new species of Camaena Albers, 1850 (Gastropoda, Stylommatophora, Camaenidae) from Guizhou and Guangxi, China
Authors: Chen Zhong-Guang , Dai Yu-Ting , Feng Shi-Yang , Wu Xiao-Ping , Jiang Jiao , Huang Xiao-Chen , Ouyang Shan 
Published: September 2024

AbstractThree new species of camaenid land snail, Camaena qiannanensis Chen, Dai, Wu & Ouyang sp. n., Camaena feichenyui Chen, Dai, Wu & Ouyang sp. n. and Camaena qinghuai Chen, Dai, Wu & Ouyang sp. n. are described from Guizhou and Guangxi of southern China based on shell and genital morphology, and molecular phylogeny. The phylogenetic result shows that the genus Camaena is not a monophyletic group, with Camaenella located within it. The discovery enhances the species diversity of Camaena in Southern China and fills the gap between distribution areas of known species.
Restoration of sexual function after surgical treatment for endometrial cancer
Authors: Solopova A. G. , Sandzhieva L. N. , Galkin V. N. , Korabelnikov D. I. , Blinov D. V. , Petrenko D. A. 
Published: September 2024

Background. Latest advances in medicine make it possible to significantly prolong the lives of patients with oncological diseases, including endometrial cancer (EC). The next medical goal is to restore the previous quality of life (QoL) level in these patients. One of the main elements of QoL in EC women is the state of sexual health. Therefore, it is necessary to develop effective rehabilitation programs aimed at overcoming sexual dysfunction in EC patients.Objective: to evaluate the effectiveness of a personalized comprehensive rehabilitation program in terms of restoring sexual function in patients after surgical treatment for EC.Material and method. A prospective, randomized, comparative study was conducted involving 61 EC women. All patients underwent radical surgical intervention. After the procedure, clinical and instrumental examinations were performed in the first week. Patients were also surveyed using the Female Sexual Function Index (FSFI) questionnaire. The participants were then divided into two groups: undergoing “active” rehabilitation (n=29) and “passive” rehabilitation (n=32). Subsequent surveys were conducted 3, 6 and 12 months after surgery. At the 3rd month after treatment, a correction of the rehabilitation program was performed in women undergoing “active” rehabilitation.Results. The FSFI sexual function assessment allowed to identify sexual dysfunction in all patients within a week after radical surgical treatment for EC. Women in both groups showed an increase in FSFI values after 3 months. Starting from the 6th month, significant differences were noted in the rate of sexual function recovery in participants who received “active” rehabilitation compared to “passive” rehabilitation group. After a comprehensive personalized 12-month rehabilitation program, the sexual function of patients in the main group improved to 24.93±2.86 points, while in the comparison group, a weak tendency to restore sexual function to 13.39±2.55 points was observed.Conclusion. The study showed a significant change in sexual function of women suffering from EC. A comprehensive personalized rehabilitation program demonstrated its effectiveness in overcoming sexual dysfunction that arose in response to surgery. The obtained results will allow expanding the evidence base to integrate interdisciplinary comprehensive personalized rehabilitation programs into routine clinical protocols for improving QoL in women after EC treatment.
Adaptation reserves in children
Authors: Bykovshchenko G. К. , Kotova О. V. , Akarachkova E. S. 
Published: September 2024

Background. Long-term chronic diseases, some types of treatment, and individual social factors have a significant stress impact on young patients. Existing rehabilitation methods are aimed at restoring body functional activity and replenishing lost adaptation reserves. However, the key features of children's adaptation to stress loads have not been fully disclosed.Objective: to reveal the key features of adaptation mechanisms to stressful influences in children.Material and methods. The search and selection of publications were carried out according to PRISMA recommendations in the scientific databases PubMed/MEDLINE, ScienceDirect, Google Scholar and the electronic libraries eLibrary, Cochrane Library. Additionally, a search was conducted in the search engines Yandex and Google. In total, 1825 publications were found. After selection, 50 of them were included in the review.Results. Low level of adaptive reserves in children to resist stress effects was identified, the key reasons for which are insufficient amounts of minerals and microelements coming into the body with food. The decrease in adaptive capacity often occurs hidden and requires close monitoring. Recommendations were presented as a means of preventing exhaustion and restoring functional activity, allowing for behavioral and psychological support for the child. Additionally, the effectiveness of magnesium-containing drugs in restoring adaptive reserves in children was shown.Conclusion. Excessive stress loads in children and adolescents have a detrimental effect on their physical and mental well-being, ability to regulate own behavior and can cause a number of chronic diseases in adulthood. Timely psychological support, nutritional control and normalization of biological rhythms will significantly increase the adaptive reserves and reduce the likelihood of chronic diseases in future as well as the burden on the healthcare system in general.