bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inactivated antithrombins as fondaparinux antidotes: a promising alternative to haemostatic agents as assessed in vitro in a thrombin-generation assay
Authors: Bourti Yasmine , Fazavana Judicael , Armand Marine , Saller François , Lasne Dominique , Borgel Delphine , Bianchini Elsa P. 
Published: July 2016

SummaryIn the absence of specific antidote to fondaparinux, two modified forms of antithrombin (AT), one recombinant inactive (ri-AT) and the other chemically inactivated (chi-AT), were designed to antagonise AT-mediated anticoagulants, e. g. heparins or fondaparinux. These inactive ATs were previously proven to effectively neutralise anticoagulant activity associated with heparin derivatives in vitro and in vivo, as assessed by direct measurement of anti-FXa activity. This study was undertaken to evaluate in vitro the effectivity of inactive ATs to reverse anticoagulation by heparin derivatives and to compare them with non-specific fondaparinux reversal agents, like recombinant-activated factor VII (rFVIIa) or activated prothrombin-complex concentrate (aPCC), in a thrombin-generation assay (TGA). Addition of fondaparinux (3 μg/ml) to normal plasma inhibited thrombin generation by prolonging lag time (LT) as much as 244 % and lowering endogenous thrombin potential (ETP) to 17 % of their control (normal plasma) values. Fondaparinux-anticoagulant activity was reversed by ri-AT and chi-AT, as reflected by the corrections of LT up to 117 % and 114 % of its control value, and ETP recovery to 78 % and 63 %, respectively. Unlike ri-AT that had no effect on thrombin generation in normal plasma, chi-AT retained anticoagulant activity that minimises its reversal capacity. However, both ATs were more effective than rFVIIa or aPCC at neutralising fondaparinux and, unlike non-specific antidotes, inactive ATs specifically reversed AT-mediated anticoagulant activities, as suggested by their absence of procoagulant activity in anticoagulant-free plasma.
Role and analysis of monocyte subsets in cardiovascular disease
Authors: Shantsila Eduard , Caligiuri Giuseppina , Guzik Tomasz , Heine Gunnar H. , Hoefer Imo E. , Monaco Claudia , Peter Karlheinz , Rainger Ed , Siegbahn Agneta , Steffens Sabine , Wojta Johann , Lip Gregory Y. H. , Weber Christian , Hristov Michael 
Published: July 2016

SummaryMonocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.Note: The review process for this paper was fully handled by Lina Badimon, Section Editor.
Everolimus-Eluting Stents in Patients With Bare-Metal and Drug-Eluting In-Stent Restenosis
Authors: Alfonso Fernando , Pérez-Vizcayno María José , García del Blanco, Bruno , García-Touchard, Arturo , López-Mínguez, José-Ramón , Masotti, Mónica , Zueco, Javier , Melgares, Rafael , Mainar, Vicente , Moreno, Raul , Domínguez, Antonio , Sanchís, Juan , Bethencourt, Armando , Moreu, José , Cequier, Angel , Martí, Vicens , Otaegui, Imanol , Bastante, Teresa , Gonzalo, Nieves , Jiménez-Quevedo, Pilar , Cárdenas, Alberto , Fernández, Cristina 
Published: July 2016

Background—
Treatment of patients with drug-eluting stent (DES) in-stent restenosis (ISR) is more challenging than that of patients with bare-metal stent ISR. However, the results of everolimus-eluting stents (EES) in these distinct scenarios remain unsettled.

Methods and Results—

A pooled analysis of the RIBS IV (Restenosis Intra-Stent of Drug-Eluting Stents: Paclitaxel-Eluting Balloon vs Everolimus-Eluting Stent) and RIBS V (Restenosis Intra-Stent of Bare Metal Stents: Paclitaxel-Eluting Balloon vs Everolimus-Eluting Stent) randomized trials was performed using patient-level data to compare the efficacy of EES in bare-metal stent ISR and DES-ISR. Inclusion and exclusion criteria were identical in both trials. Results of 94 patients treated with EES for bare-metal stent ISR were compared with those of 155 patients treated with EES for DES-ISR. Baseline characteristics were more adverse in patients with DES-ISR, although they presented later and more frequently with a focal pattern. After intervention, minimal lumen diameter (2.22±0.5 versus 2.38±0.5 mm,
P
=0.01) was smaller in the DES-ISR group. Late angiographic findings (89.3% of eligible patients), including minimal lumen diameter (2.03±0.7 versus 2.36±0.6 mm,
P
<0.001) and diameter stenosis (23±22 versus 13±17%,
P
<0.001) were poorer in patients with DES-ISR. Results were consistent in the in-segment and in-lesion analyses. On multiple linear regression analysis, minimal lumen diameter at follow-up remained significantly smaller in patients with DES-ISR. Finally, at 1-year clinical follow-up (100% of patients), mortality (2.6 versus 0%,
P
<0.01) and need for target vessel revascularization (8 versus 2%,
P
=0.03) were higher in the DES-ISR group.

Conclusions—
This patient-level pooled analysis of the RIBS IV and RIBS V randomized clinical trials suggests that EES provide favorable outcomes in patients with ISR. However, the results of EES are less satisfactory in patients with DES-ISR than in those with bare-metal stent ISR.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifiers: NCT01239953 and NCT01239940.
Trends in Cardiovascular Health Metrics in Obese Adults: National Health and Nutrition Examination Survey (NHANES), 1988–2014
Authors: Guo Fangjian , Garvey W. Timothy 
Published: July 2016

Background
No study has quantified trends in the prevalence of cardiovascular disease risk factors and cardiovascular health metrics among obese people in the United States in recent years.

Methods and Results

We examined the secular changes in cardiovascular health metrics and key cardiovascular disease risk factors among obese adults (aged ≥20 years) in the United States. We included 18 626 obese adults (body mass index ≥30) from the National Health and Nutrition Examination Survey (
NHANES
)
III
and
NHANES
1999–2014. Among those obese adults, there were decreases in mean systolic blood pressure, diastolic blood pressure, and total cholesterol levels and increases in mean high‐density lipoprotein cholesterol levels and mean hemoglobin A1c levels. Prevalence of blood pressure health and lipid health remained stable during the period 1988–2014, whereas prevalence of blood glucose health decreased significantly during this period. Prevalence of freedom from cardiovascular disease risk factors remained stable at ≈15% among the adult obese population during the period 1988–2014, whereas prevalence of presence of all 3 risk factors increased from 16.4% to 22.4% during this period, commensurate with a decline in those with 1 to 2 risk factors (from 69.6% to 62.4%).

Conclusions
During the past 3 decades, blood pressure health and blood lipid health remained stable or improved, whereas blood glucose health deteriorated among adult obese population. This resulted in an overall decrease in cardiovascular health status among obese adults and greater risk of type 2 diabetes mellitus. The data argue for interventions targeted to those obese persons who are metabolically unhealthy to stem rising rates of diabetes mellitus.
Neoalloionema indicum n. sp. (Nematoda: Alloionematidae), a new alloionematid from India
Authors: Nermuť Jiří , Půža Vladimír , Mráček Zdeněk 
Published: July 2016

A new nematode species belonging to the family Alloionematidae was originally isolated by Dr Marie Anne Félix on 16 December 2007 from a rotting coconut at the boat boarding point in Estuary island resort, Poovar, Kerala, India. Both morphologically and molecularly, the new isolate resemblesNeoalloionema tricaudatumbut, unlikeN. tricaudatumthis species has no phasmidial ‘horns’ in the juvenile stage, even though prominent structures in the mid-tail of dauer juveniles were observed. Females are characterised by a body length of 947 (869-1030) μm, vulva in the mid-body region, long, and tapering tail with a minute post-anal swelling. Males are 678 (606-757) μm long with a long tapering tail that is very thick at base. They are further characterised by seven pairs of genital papillae and a single genital papilla. Dauer juveniles are only 391 (364-434) μm long, thin and almost straight when heat-killed. Large, prominent phasmids are located laterally at the mid-tail region and lateral fields consisting of a single ridge are present. Several morphological and molecular differences encouraged us to describe the nematode asN. indicumn. sp. The ecology of the newly described species is unknown, but it is probably a saprophytic bacteriophagous nematode preferring rotting organic material.
Clinical and laboratory predictors of coronary slow flow in coronary angiography
Authors: Ghaffari Samad , Tajlil Arezou , Aslanabadi Naser , Separham Ahmad , Sohrabi Bahram , Saeidi Gholamreza , Pourafkari Leili 
Published: July 2016

Background: The coronary slow-flow phenomenon (CSFP) is a multifactorial angiographic finding with no established pathogenesis. Objective: To investigate the role of clinical profile and laboratory findings in patients with CSFP. Methods: We prospectively recruited 69 patients with angiographically diagnosed CSFP and compared them with 88 patients with normal coronary flow. Demographic information, comorbidities and laboratory analysis, including complete blood count with differential, lipid profile and serum biochemical analysis, were documented and compared in univariate and multivariate analyses. Results: Patients with CSFP were more likely to be male and active smokers. Total cholesterol, triglyceride, hemoglobin and hematocrit, platelet count, mean platelet volume, platelet distribution width and red cell distribution width (RDW) were all higher in patients with CSFP. In multivariate regression analysis, including smoking, total cholesterol, hematocrit, fasting blood glucose and red cell distribution width, except fasting blood glucose, all variables were independently associated with CSFP. Receiver operating characteristic curve analysis revealed a cut-off point of 13.05% for RDW with a sensitivity of 74.6% and a specificity of 77.3% (p<0.001, AUC = 0.802) A cut-off value of 11.35% for PDW had a 89.9% sensitivity and 98.9% specificity for the prediction of CSFP (p<0.001, AUC = 0.970) Conclusion: The changes of circulating blood cell components in patients with CSFP may be indicative of underlying inflammation and endothelial dysfunction that should be investigated in experimental studies.
A multicenter, randomized trial on neuroprotection with remote ischemic per-conditioning during acute ischemic stroke: the REmote iSchemic Conditioning in acUtE BRAin INfarction study protocol
Authors: Pico Fernando , Rosso Charlotte , Meseguer Elena , Chadenat Marie-Laure , Cattenoy Amina , Aegerter Philippe , Deltour Sandrine , Yeung Jennifer , Hosseini Hassan , Lambert Yves , Smadja Didier , Samson Yves , Amarenco Pierre 
Published: July 2016

Rationale Remote ischemic per-conditioning—causing transient limb ischemia to induce ischemic tolerance in other organs—reduces final infarct size in animal stroke models. Aim To evaluate whether remote ischemic per-conditioning during acute ischemic stroke (<6 h) reduces brain infarct size at 24 h. Methods and design This study is being performed in five French hospitals using a prospective randomized open blinded end-point design. Adults with magnetic resonance imaging confirmed ischemic stroke within 6 h of symptom onset and clinical deficit of 5–25 according to National Institutes of Health Stroke Scale will be randomized 1:1 to remote ischemic per-conditioning or control (stratified by center and intravenous fibrinolysis use). Remote ischemic per-conditioning will consist of four cycles of electronic tourniquet inflation (5 min) and deflation (5 min) to a thigh within 6 h of symptom onset. Magnetic resonance imaging is repeated 24 h after stroke onset. Sample size estimates For a difference of 15 cm3 in brain infarct growth between groups, 200 patients will be included for 5% significance and 80% power. Study outcomes The primary outcome will be the difference in brain infarct growth from baseline to 24 h in the intervention versus control groups (by diffusion-weighted image magnetic resonance imaging). Secondary outcomes include: National Institutes of Health Stroke Scale score absolute difference between baseline and 24 h, three-month modified Rankin score and daily living activities, mortality, and tolerance and side effects of remote ischemic per-conditioning. Discussion The only remote ischemic per-conditioning trial in humans with stroke did not show remote ischemic per-conditioning to be effective. REmote iSchemic Conditioning in acUtE BRAin INfarction, which has important design differences, should provide more information on the use of this intervention in patients with acute ischemic stroke.
T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma
Authors: Ali Syed Abbas , Shi Victoria , Maric Irina , Wang Michael , Stroncek David F. , Rose Jeremy J. , Brudno Jennifer N. , Stetler-Stevenson Maryalice , Feldman Steven A. , Hansen Brenna G. , Fellowes Vicki S. , Hakim Frances T. , Gress Ronald E. , Kochenderfer James N. 
Published: July 2016

Key Points
Anti-BCMA T cells have impressive activity against MM.
A multidisciplinary cognitive behavioural programme for coping with chronic neuropathic pain following spinal cord injury: the protocol of the CONECSI trial
Authors: Heutink Matagne , Post Marcel WM , Luthart Peter , Pfennings Lilian EMA , Dijkstra Catja A , Lindeman Eline 
Published: July 2016

Abstract

Background
Most people with a spinal cord injury rate neuropathic pain as one of the most difficult problems to manage and there are no medical treatments that provide satisfactory pain relief in most people. Furthermore, psychosocial factors have been considered in the maintenance and aggravation of neuropathic spinal cord injury pain. Psychological interventions to support people with spinal cord injury to deal with neuropathic pain, however, are sparse. The primary aim of the CONECSI (COping with NEuropathiC Spinal cord Injury pain) trial is to evaluate the effects of a multidisciplinary cognitive behavioural treatment programme on pain intensity and pain-related disability, and secondary on mood, participation in activities, and life satisfaction.

Methods/Design
CONECSI is a multicentre randomised controlled trial. A sample of 60 persons with chronic neuropathic spinal cord injury pain will be recruited from four rehabilitation centres and randomised to an intervention group or a waiting list control group. The control group will be invited for the programme six months after the intervention group. Main inclusion criteria are: having chronic (> 6 months) neuropathic spinal cord injury pain as the worst pain complaint and rating the pain intensity in the last week as 40 or more on a 0-100 scale. The intervention consists of educational, cognitive, and behavioural elements and encompasses 11 sessions over a 3-month period. Each meeting will be supervised by a local psychologist and physical therapist. Measurements will be perfomed before starting the programme/entering the control group, and at 3, 6, 9, and 12 months. Primary outcomes are pain intensity and pain-related disability (Chronic Pain Grade questionnaire). Secondary outcomes are mood (Hospital Anxiety and Depression Scale), participation in activities (Utrecht Activities List), and life satisfaction (Life Satisfaction Questionnaire). Pain coping and pain cognitions will be assessed with three questionnaires (Coping Strategy Questionnaire, Pain Coping Inventory, and Pain Cognition List).

Discussion
The CONECSI trial will reveal the effects of a multidisciplinary cognitive behavioural programme for people with chronic neuropathic spinal cord injury pain. This intervention is expected to contribute to the rehabilitation treatment possibilities for this population.

Trial Registration
Dutch Trial Register NTR1580.
Jump event of mid-ocean ridge during the eastern subbasin evolution of the South China Sea
Authors: Qiu Yan , Wang Yingmin , Huang Wenkai , Li Weiguo , Zhuo Haiteng , Du Wenbo , Gong Chenglin 
Published: July 2016

The South China Sea is one of the largest marginal seas in the Western Pacific region, and it has been widely accepted that the evolution of the basin and the development of its oceanic crusts is closely linked to seafloor spreading. A great controversy, however, is around whether or not there was a jump of mid-ocean ridges during seafloor spreading, particularly in the eastern South China Sea subbasin. A tectonostratigraphic interpretation using high-resolution seismic data demonstrated that: (1) a southward jump event of the mid-ocean ridge took place in the eastern subbasin during the seafloor spreading; (2) the orientation of the mid-ocean ridge had dramatically changed after the event resulting in that the abandoned mid-ocean ridge is along an east–west direction, whereas the younger one is generally east–northeast/west–southwest oriented; (3) the corresponding surface caused by the jump tectonic event and the pre-event sequence can be traced throughout the earlier formed oceanic crust; and (4) paleo-magnetic data showed that the event occurred at approximately 25–23.8 Ma. The results of this study could be used to better understand the evolution and filling of the South China Sea and other associated marginal basins.
Microtubule-independent secretion requires functional maturation of Golgi elements
Authors: Fourriere Lou , Divoux Severine , Roceri Mila , Perez Franck , Boncompain Gaelle 
Published: July 2016

ABSTRACT
The Golgi complex is responsible for processing and sorting of secretory cargos. Microtubules are known to accelerate the transport of proteins from the endoplasmic reticulum (ER) to the Golgi complex and from the Golgi to the plasma membrane. However, whether post-Golgi transport strictly requires microtubules is still unclear. Using the retention using selective hooks (RUSH) system to synchronize the trafficking of cargos, we show that anterograde transport of tumor necrosis factor (TNF) is strongly reduced without microtubules. We show that two populations of Golgi elements co-exist in these cells. A centrally located and giantin-positive Golgi complex that sustains trafficking, and newly formed peripheral Golgi mini-stacks that accumulate cargos in cells without microtubules. Using a genome-edited GFP–giantin cell line, we observe that the trafficking-competent Golgi population corresponds to the pre-existing population that was present before removal of microtubules. All Golgi elements support trafficking after long-term depletion of microtubules and after relocation of Golgi proteins to the ER after treatment with Brefeldin A. Our results demonstrate that functional maturation of Golgi elements is needed to ensure post-Golgi trafficking, and that microtubule-driven post-Golgi transport is not strictly required.
Disruption Risk and Optimal Sourcing in Multitier Supply Networks
Authors: Ang Erjie , Iancu Dan A. , Swinney Robert 
Published: July 2016

We study sourcing in a supply chain with three levels: a manufacturer, tier 1 suppliers, and tier 2 suppliers prone to disruption from, e.g., natural disasters such as earthquakes or floods. The manufacturer may not directly dictate which tier 2 suppliers are used but may influence the sourcing decisions of tier 1 suppliers via contract parameters. The manufacturer’s optimal strategy depends critically on the degree of overlap in the supply chain: if tier 1 suppliers share tier 2 suppliers, resulting in a “diamond-shaped” supply chain, the manufacturer relies less on direct mitigation (procuring excess inventory and multisourcing in tier 1) and more on indirect mitigation (inducing tier 1 suppliers to mitigate disruption risk). We also show that while the manufacturer always prefers less overlap, tier 1 suppliers may prefer a more overlapped supply chain and hence may strategically choose to form a diamond-shaped supply chain. This preference conflict worsens as the manufacturer’s profit margin increases, as disruptions become more severe, and as unreliable tier 2 suppliers become more heterogeneous in their probability of disruption; however, penalty contracts—in which the manufacturer penalizes tier 1 suppliers for a failure to deliver ordered units—alleviate this coordination problem. This paper was accepted by Yossi Aviv, operations management.
Renegotiating gender through dress in Bollywood: The new Indian woman
Authors: Strubel Jessica , Josiam Bharath M. 
Published: July 2016

Abstract
Drawing upon the components of the social role theory and postcolonial theory, this study examined the role of Bollywood diaspora films on the formation or renegotiation of identity among non-resident Indian women as manifested in their dress. We were specifically interested in the creation of a new hybrid Indian identity for young women of the diaspora, the women who are able to move seamlessly between their two worlds, and in looking at the role of Bollywood as it reconciles traditional Indian values with the progress of postcolonial India.
8. Bremer eBook-Tag
Authors: Krug Katharina 
Published: July 2016

Zusammenfassung
Seit 2006 richtet der Bibliotheksdienstleister Missing Link den Bremer eBook-Tag aus. Auf der diesjährigen Veranstaltung ging es schwerpunktmäßig um das Thema Metadaten und um den Umgang mit elektronischen Medien an den Universitäten und Hochschulen. Weiterhin wurden Neuerungen im E-Book-Bereich vorgestellt und zukunftsfähige Entwicklungen im Bereich elektronisches Lehrbuch diskutiert. Der vorliegende Beitrag bietet einen Überblick über die Veranstaltung und fasst die Vorträge zusammen.
Cold hardening protects cereals from oxidative stress and necrotrophic fungal pathogenesis
Authors: Pogány Miklós , Harrach Borbála , Bozsó Zoltán , Künstler András , Janda Tibor , von Rad Uta , Vida Gyula , Veisz Ottó 
Published: July 2016

AbstractThe effects of cold hardening of cereals on their cross-tolerance to treatments leading to oxidative stress were investigated. Long-term exposure to low non-freezing temperatures provided partial protection to wheat and barley plants from the damage caused by paraquat and hydrogen peroxide treatments. It also conferred resistance in two barley cultivars to the necrotic symptoms and growth of the fungal phytopathogen Pyrenophora teres f. teres. Pathogen-induced oxidative burst was also reduced in cold hardened plants. The possible roles of host-derived redox factors and other signaling components in the observed forms of cereal cross-tolerance are discussed.