bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on Lyapunov‐function‐based control schemes for single‐phase grid‐connected voltage‐source inverter with LCL filter
Authors: Sefa Ibrahim , Ozdemir Saban , Komurcugil Hasan , Altin Necmi 
Published: July 2017

This study deals with various Lyapunov‐function‐based control (LFBC) schemes proposed for a single‐phase grid‐connected voltage source inverter with LCL filter. Use of LCL filter causes resonance which may adversely affect the controller's stability. The conventional (CLFBC) scheme employing the inverter‐side current guarantees the asymptotic global stability, but it is not able to damp the resonance. As a remedy to the poor resonance damping, the adoption of grid‐current and capacitor‐voltage feedback schemes have been investigated. Although the former offers a globally asymptotically stable system, it cannot improve the poor resonance damping. However, the CLFBC with capacitor‐voltage feedback scheme not only preserves the global stability, but also improves the resonance damping substantially. The analytical equations of the closed‐loop poles for each control scheme are provided which can be used to compute the pole positions and the damping ratio needed for a desired response. Furthermore, the effect of changing controller gains on the loci of closed‐loop poles is also studied. Simulation and experimental results obtained from 3.3 kW system demonstrate that the CLFBC with capacitor‐voltage feedback scheme not only offers a global stability, but also leads to good quality sinusoidal grid current with reasonable total harmonic distortion and fast dynamic response.
Characterization of micro-RNA Profile in the Blood of Patients with Marfan's Syndrome
Authors: Ludwig Nicole , Rädle-Hurst Tanja , Keller Andreas , Motsch Lars , Marsollek Ina , El Rahman Mohammed , Abu-Halima Masood , Abdul-Khaliq Hashim , Meese Eckart 
Published: July 2017

Background Marfan's syndrome (MFS) is an autosomal dominant inheritance disorder with a 1/5,000 live-birth prevalence. It is characterized by a wide range of clinical manifestations with more than 3,000 mutations identified in the FBN1 gene. In this study, we aimed to determine if specific patterns of circulating micro-RNAs (miRNAs) are associated with MFS-associated with cardiovascular diseases.
Methods Microarray-based miRNA profiling was performed on blood samples of 12 MFS patients, and 12 healthy volunteers (HVs) controls and the differences in miRNA abundance between the two groups were validated using independent cohorts of 22 MFS and of 22 HV controls by real-time quantitative polymerase chain reaction (RT-qPCR). Enrichment analyses of altered miRNA abundance were predicted using bioinformatics tools.
Results Altered miRNA abundance levels were determined between MFS (n = 34) and HVs (n = 34). In a screening phase, we analyzed 12 patients with MFS and 12 HVs by miRNA microarray. We found 198 miRNAs that were significantly altered in MFS patients as compared with HVs, including 16 miRNAs with a more than 1.5-fold change. Out of these 16 miRNAs, 10 showed a decreased abundance and 6 showed an increased abundance. In the validation phase, we analyzed independent cohorts of 22 MFS and of 22 HV controls by RT-qPCR. We confirmed the direction of abundance changes and the significance of different abundances between MFS patients and HVs for four miRNAs, namely, miR-362–5p, miR-339–3p, miR-340–5p, and miR-210–3p. Only the miR-150–5p showed a significant correlation with mitral valve prolapse (p = 0.010). The predicted targets for the validated miRNAs were associated with signal transduction, tissue remodeling, and cellular interaction pathways.
Conclusion The altered abundance level of different miRNAs in whole blood of MFS patients lays the ground to the development of novel diagnostic approaches with altered miRNAs levels associated with MFS with manifestations associated with cardiovascular diseases.
Revision der repertorialen Systematik der Gemütssymptome
Authors: Waldvogel Lutz , Schäferkordt Rainer 
Published: July 2017

ZusammenfassungEs wird ein Überblick gegeben über die Systematik der Gemütssymptome in den klassischen homöopathischen Werken, die zumindest für die heutige Praxis als unzureichend erachtet werden muss. Anschließend wird der Ansatz der Glopedia-Arbeitsgruppe vorgestellt, die eine grundlegende Neustrukturierung des homöopathischen Arzneiwissens zum Ziel hat. Explizit wird auf das Konzept der semantischen Hierarchien eingegangen.
The Compact Wheelchair Roller Dynamometer
Authors: Oliveira Saulo , Bione Afonso , Oliveira Lúcia , da Costa Adalberto , de Sá Pereira Guimarães Fernando , da Cunha Costa Manoel 
Published: July 2017

AbstractThe equipment for evaluating the propulsion of a wheelchair is very complex and expensive. To validate a new dynamometer prototype for assessing the propulsion capacity of wheelchairs, 21 healthy subjects (age: 20.9±2.4 yr; weight: 68.9±7.9 kg; height: 174.0±7.1 cm; BMI: 22.7±2.5 kg·m−2) who do not normally require wheelchairs performed a sprint protocol for 20 s after a 1-min warm-up. The power and rotation data acquired by the prototype (both right and left sides) were compared with those of a reference system via high-speed videography (240 fps). The results showed high levels of accordance (95% CI), excellent values for the intraclass correlation coefficient (ICC: .99; P<0.00), no significant differences in the rotation (P=0.91) and power (P=0.94) between the methods. The proposed equipment met the validation criteria and thus can be applied as a new tool for assessing wheelchair propulsion.
Road Map fluoroscopy successfully guides endoscopic interventions in the esophagus
Authors: Weigt Jochen , Obst Wilfried , Kandulski Arne , Pech Maciej , Canbay Ali , Malfertheiner Peter 
Published: July 2017

Abstract
Background and study aims Road Map (RM) fluoroscopy is a radiological technique that enables visualization of anatomic structures using image subtraction at peak opacification. RM fluoroscopy has never previously been evaluated for use in endoscopy. The aim of this study was to evaluate the usefulness of RM in guiding endoscopic intervention in the esophagus.
Patients and methods This was a monocentric observational trial of consecutive patients with esophageal strictures in a university hospital. Twenty-seven investigations using RM were performed in 24 patients undergoing esophageal endoscopy. Indications for the procedure were balloon dilatation (n = 7 including 2 pneumatic balloon dilatations for treatment of achalasia), bougie dilatation (n = 7) and diagnostic endoscopy (n = 1). In addition, 12 stents, 7 partially covered and 5 fully covered, were placed using RM as a guide for determination of stent length and diameter. Stents were deployed under RM guidance.
Results In all procedures, RM successfully guided the intervention. Endoscopic control endoscopy confirmed adequate stent placement in all cases.The feeling of resistance during bougie dilation matched the RM-predicted location of the stenosis. With the help of RM imaging, dilatation balloons were easily centered inside the stenosis and thus slipping of the balloon was avoided. There were no adverse events.
Conclusion RM allows permanent and accurate radiographic imaging of stenoses and esophageal anatomic changes. It is an easy and safe method of guiding endoscopic interventions that require radiological imaging.
Wettbewerb im niederländischen Krankenhaussektor – Eine Analyse der Gesundheitsversorgung und der
Kosten
Authors: Bretzke Pascal 
Published: July 2017

Krabbe-Alkemade YJFM, Groot TLCM, Lindeboom M. Competition in the Dutch hospital sector: an analysis of health care volume and cost. Eur J
Health Econ 2017; 18: 139–153
Das niederländische Gesundheitssystem befindet sich seit einigen Jahren im Wandel. Seit Beginn 2005 wurde ein neues Erstattungssystem in
den niederländischen Krankenhäusern eingeführt, mit dem Ziel, neue Effizienzreserven zu erschließen und einen stärkeren Wettbewerb unter
Versorgungseinrichtungen zu generieren. Basierend auf Entlassungsdaten haben die Autoren die Auswirkungen des Marktwettbewerbs auf das
Krankenhausverhalten analysiert.
Development of the Rope-Climbing Ergometer for Physical Training and Testing
Authors: Arakawa Hiroshi , Kumagawa Daisuke , Fujisaki Iwao , Ozawa Yoshiaki , Ishige Yusuke 
Published: July 2017

AbstractThe purpose of this study was to develop and characterize a rope-climbing ergometer. A custom-made loading device that has an eddy current brake with an electrical current control circuit was developed to impose resistive load on the rope. A calibration test was first performed using a three-phase induction motor to associate the scale of the load-level setting (100 levels) with the resultant traction force. The calibration test yielded criteria values of loads (123 N at Level 0 and 1064 N at Level 100). The human test was carried out by 14 male subjects. The participants performed eight sets of 10-second maximal-effort exercises at different levels. Presumable trajectories of force, velocity, and power were obtained. The mean force increased by 161% (from 147.5 N at Level 0 to 383.7 N at Level 18), whereas the mean velocity decreased by 64.7% (from 1.87 m/s at Level 0 to 0.66 m/s at Level 18). The mean power reached its peak at Level 9 (320 W). The new rope ergometer for physical training and testing was successfully developed and characterized in this study. However, it remains to be seen whether its concurrent validity and reliability are qualifiable.
‘She used his name’: provider trait mindfulness in perinatal death counselling / ‘Ella usó el nombre de él’: mindfulness de los rasgos del proveedor en la terapia por muerte perinatal
Authors: Cacciatore Joanne 
Published: July 2017

Millions of babies die of stillbirth every year around the world, yet there is a dearth of research on the helping behaviours of counsellors working with grieving families. Mindfulness-based interventions have been increasingly used, and researched, in vulnerable populations. While many studies have empirically focused on mindfulness as an intervention, very few studies have examined trait mindfulness in providers and its relationship to perceptions of helping. This study is an open-ended inquiry to explore trait, or dispositional, mindfulness in counsellors/therapists as perceived by bereaved parents in the aftermath of perinatal death. Descriptive data are reported, and a thematic analysis that identified and coded recurring and unifying statements was performed on the qualitative response ( n = 94). Findings suggest that trait mindfulness in counsellors/therapists is perceived as helpful and inverse findings were also discovered.
Reactome enhanced pathway visualization
Authors: Sidiropoulos Konstantinos , Viteri Guilherme , Sevilla Cristoffer , Jupe Steve , Webber Marissa , Orlic-Milacic Marija , Jassal Bijay , May Bruce , Shamovsky Veronica , Duenas Corina , Rothfels Karen , Matthews Lisa , Song Heeyeon , Stein Lincoln , Haw Robin , D’Eustachio Peter , Ping Peipei , Hermjakob Henning , Fabregat Antonio 
Published: July 2017

Abstract

Motivation
Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts like immune system to detailed pathway diagrams showing biomolecular events like membrane transport or phosphorylation. Here, we present new developments in the Reactome visualization system that facilitate navigation through the pathway hierarchy and enable efficient reuse of Reactome visualizations for users’ own research presentations and publications.

Results
For the higher levels of the hierarchy, Reactome now provides scalable, interactive textbook-style diagrams in SVG format, which are also freely downloadable and editable. Repeated diagram elements like ‘mitochondrion’ or ‘receptor’ are available as a library of graphic elements. Detailed lower-level diagrams are now downloadable in editable PPTX format as sets of interconnected objects.

Availability and implementation
http://reactome.org
Do Banks Pass through Credit Expansions to Consumers Who want to Borrow?*
Authors: Agarwal Sumit , Chomsisengphet Souphala , Mahoney Neale , Stroebel Johannes 
Published: July 2017

AbstractWe propose a new approach to studying the pass-through of credit expansion policies that focuses on frictions, such as asymmetric information, that arise in the interaction between banks and borrowers. We decompose the effect of changes in banks’ cost of funds on aggregate borrowing into the product of banks’ marginal propensity to lend (MPL) to borrowers and those borrowers’ marginal propensity to borrow (MPB), aggregated over all borrowers in the economy. We apply our framework by estimating heterogeneous MPBs and MPLs in the U.S. credit card market. Using panel data on 8.5 million credit cards and 743 credit limit regression discontinuities, we find that the MPB is declining in credit score, falling from 59% for consumers with FICO scores below 660 to essentially zero for consumers with FICO scores above 740. We use a simple model of optimal credit limits to show that a bank’s MPL depends on a small number of parameters that can be estimated using our credit limit discontinuities. For the lowest FICO score consumers, higher credit limits sharply reduce profits from lending, limiting banks’ optimal MPL to these consumers. The negative correlation between MPB and MPL reduces the impact of changes in banks’ cost of funds on aggregate household borrowing, and highlights the importance of frictions in bank-borrower interactions for understanding the pass-through of credit expansions.
Chromium oxide coatings with the potential for eliminating the risk of chromium ion release in orthopaedic implants
Authors: Oje A. M. , Ogwu A. A. 
Published: July 2017

Chromium oxide coatings prepared by radiofrequency reactive magnetron sputtering on stainless steel substrates were exposed to Ringer's physiological solution and tested for their electrochemical corrosion stability using an open circuit potential measurement, potentiodynamic polarization, electrochemical impedance spectroscopy and Mott–Schottky analysis. The coatings were found to be predominantly Cr2O3, based on the observation of the dominance ofA1gand Egsymmetric modes in our Raman spectroscopic investigation and the Euvibrational modes in our Fourier transform infrared spectroscopic measurements on the coatings. We investigated for the presence of chromium ions in Ringer's solution after all of the above electrochemical tests using atomic absorption spectroscopy, without finding a trace of chromium ions at the ppm level for coatings tested under open circuit and at the lower potentials implants are likely to experience in the human body. The coatings were further exposed to Ringer's solution for one month and tested for adhesion strength changes, and we found that they retained substantial adhesion to the substrates. We expect this finding to be significant for future orthopaedic implants where chromium ion release is still a major challenge.
Tracheophyte genomes keep track of the deep evolution of theCaulimoviridae
Authors: Diop Seydina , Geering Andrew D.W. , Alfama-Depauw Françoise , Loaec Mikaël , Teycheney Pierre-Yves , Maumus Florian 
Published: July 2017

AbstractEndogenous viral elements (EVEs) are viral sequences that are integrated in the nuclear genomes of their hosts and are signatures of viral infections that may have occurred millions of years ago. The study of EVEs, coined paleovirology, provides important insights into virus evolution. TheCaulimoviridaeis the most common group of EVEs in plants, although their presence has often been overlooked in plant genome studies. We have refined methods for the identification of caulimovirid EVEs and interrogated the genomes of a broad diversity of plant taxa, from algae to advanced flowering plants. Evidence is provided that almost every vascular plant (tracheophyte), including the most primitive taxa (clubmosses, ferns and gymnosperms) contains caulimovirid EVEs, many of which represent previously unrecognized evolutionary branches. In angiosperms, EVEs from at least one and as many as five different caulimovirid genera were frequently detected, and florendoviruses were the most widely distributed, followed by petuviruses. From the analysis of the distribution of different caulimovirid genera within different plant species, we propose a working evolutionary scenario in which this family of viruses emerged at latest during Devonian era (approx. 320 million years ago) followed by vertical transmission and by several cross-division host swaps.
Single nucleus analysis of the chromatin landscape in mouse forebrain development
Authors: Preissl Sebastian , Fang Rongxin , Zhao Yuan , Raviram Ramya , Zhang Yanxiao , Sos Brandon C. , Huang Hui , Gorkin David U. , Afzal Veena , Dickel Diane E. , Kuan Samantha , Visel Axel , Pennacchio Len A. , Zhang Kun , Ren Bing 
Published: July 2017

ABSTRACTGenome-wide analysis of chromatin accessibility in primary tissues has uncovered millions of candidate regulatory sequences in the human and mouse genomes1–4. However, the heterogeneity of biological samples used in previous studies has prevented a precise understanding of the dynamic chromatin landscape in specific cell types. Here, we show that analysis of the transposase-accessible-chromatin in single nuclei isolated from frozen tissue samples can resolve cellular heterogeneity and delineate transcriptional regulatory sequences in the constituent cell types. Our strategy is based on a combinatorial barcoding assisted single cell assay for transposase-accessible chromatin5and is optimized for nuclei from flash-frozen primary tissue samples (snATAC-seq). We used this method to examine the mouse forebrain at seven development stages and in adults. From snATAC-seq profiles of more than 15,000 high quality nuclei, we identify 20 distinct cell populations corresponding to major neuronal and non-neuronal cell-types in foetal and adult forebrains. We further define cell-type specificcisregulatory sequences and infer potential master transcriptional regulators of each cell population. Our results demonstrate the feasibility of a general approach for identifying cell-type-specificcisregulatory sequences in heterogeneous tissue samples, and provide a rich resource for understanding forebrain development in mammals.
Fixed effect variance and the estimation of the heritability: Issues and solutions
Authors: de Villemereuil Pierre , Morrissey Michael B. , Nakagawa Shinichi , Schielzeth Holger 
Published: July 2017

AbstractLinear mixed effects models are frequently used for estimating quantitative genetic parameters, including the heritability, of traits of interest. Heritability is an important metric, because it acts as a filter that determines how efficiently phenotypic selection translates into evolutionary change. As a quantity of biological interest, it is important that the denominator, the phenotypic variance, actually reflects the amount of phenotypic variance in the relevant ecological stetting. The current practice of quantifying heritability from mixed effects models frequently deprives the heritability of variance explained by fixed effects (often leading to upward-bias) and it has been suggested to omit fixed effects when estimating heritabilities. We advocate an alternative option of fitting complex models incorporating all relevant effects, while including the variance explained by fixed effects into the estimation of heritabilities. The approach is easily implemented (an example is provided) and allows corrections for the estimation of heritability, such as the exclusion of variance arising from experimental design effects while still including all biologically relevant sources of variation. We explore the complications arising depending on the nature of the covariates included as fixed effects (e.g. biological or experimental origin, characteristics of biological covariates). Furthermore, we discuss fixed effects in non-linear and generalized linear models when fixed effects. In these cases, the variance parameters depend on the location of the intercept and hence on the scaling of the fixed effects. Integration over the biologically relevant range of fixed effects offers a preferred solution in those situations.
STRetch: detecting and discovering pathogenic short tandem repeat expansions
Authors: Dashnow Harriet , Lek Monkol , Phipson Belinda , Halman Andreas , Sadedin Simon , Lonsdale Andrew , Davis Mark , Lamont Phillipa , Clayton Joshua S. , Laing Nigel G. , MacArthur Daniel G. , Oshlack Alicia 
Published: July 2017

AbstractShort tandem repeat (STR) expansions have been identified as the causal DNA mutation in dozens of Mendelian diseases. Historically, pathogenic STR expansions could only be detected by single locus techniques, such as PCR and electrophoresis. The ability to use short read sequencing data to screen for STR expansions has the potential to reduce both the time and cost to reaching diagnosis and enable the discovery of new causal STR loci. Most existing tools detect STR variation within the read length, and so are unable to detect the majority of pathogenic expansions. Those tools that can detect large expansions are limited to a set of known disease loci and as yet no new disease causing STR expansions have been identified with high-throughput sequencing technologies.Here we address this by presenting STRetch, a new genome-wide method to detect STR expansions at all loci across the human genome. We demonstrate the use of STRetch for detecting pathogenic STR expansions in short-read whole genome sequencing data with a very low false discovery rate. We further demonstrate the application of STRetch to solve cases of patients with undiagnosed disease and apply STRetch to the analysis of 97 whole genomes to reveal variation at STR loci. STRetch assesses expansions at all STR loci in the genome and allows screening for novel disease-causing STRs.STRetch is open source software, available fromgithub.com/Oshlack/STRetch.
Genome-wide identification of intrasplicing events in the human transcriptome and hints to their regulatory potential
Authors: Radtke Maximilian , Srndic Ismet , Schroeder Renée 
Published: July 2017

AbstractAlternative splicing is one of the major regulators of both, transcriptome diversity and individual isoform abundance. Therefore regulation of alternative splicing is crucial and yet, due to the complexity of the human genome (23.000 genes, most of which can be alternatively spliced) diverse and multileveled. Identifying and understanding the scope and variety of splicing events is still an ongoing process. We established a novel pipeline to extract splicing events from specific RNA-sequencing datasets and identified numerous splicing events that did not span the entirety of the respective annotated intron but used intronic splice sites. These splicing events could be generally categorized into three groups: 5’recursive (using the exonic splice donor and intronic acceptor), 3’recursive (using an intronic splice donor and an exonic acceptor) and nested (using two intronic splice sites). Surprisingly, the splicing events we found occurred in introns of all lengths, but generally followed the abundance scheme of all introns, i.e. most were found in introns between 500 and 5000 bps. After confirmation of these splice events by conventional methodologies, we further analyzed the impact of intrasplicing on full intron removal. For this we established a luciferase-based reporter which showed that these intronic splicing steps can be beneficial, deleterious or neutral for full intron removal. Thus intrasplicing events can be crucial for determining the transcriptional output. This in part confirms recent findings on recursive splicing events in humans and other vertebrates and further uncovers an additional level of transcriptome regulation based on a yet undiscovered level of flexibility and regulation of splice site selection and its impact on gene expression.