bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chylous Ascites: A Rare Complication After Donor Right Hepatectomy
Authors: Badawy Amr , Mourad Mohamed , Sharan Mohamed Abdallah , Elyamany Amany Saleh , Elgendi Ahmed , Said Hany , Bahaa Mohamed , Abdelghafar Mohamed Fathy 
Published: September 2024

Abstract
Chylous ascites (CA) is a rare complication after abdominal surgeries, particularly donor hepatectomy and liver transplantation. We present a case of CA developed following donor right hepatectomy. Initially managed with a high-protein, low-fat diet and Sandostatin® (Octreotide Acetate), the patient’s condition improved but did not resolve. Subsequently, the treatment plan was modified to include clear oral fluids, total parenteral nutrition, and Sandostatin®, resulting in a significant improvement and ultimate discontinuation of CA drainage. This case sheds light on the management strategies for CA following donor hepatectomy and emphasizes the need for a multimodal approach.
Factors Affecting Cardiorespiratory Fitness in Middle-Aged Men
Authors: Jeevrajani Jeel Mahendrabhai , Sheth Megha 
Published: September 2024

Abstract

Introduction:
Cardiorespiratory fitness (CRF) is “the ability of the circulatory and respiratory systems to supply oxygen during sustained physical activity (PA).” CRF is a well-established predictor of a wide range of negative health outcomes. Six-minute walk distance (6MWD) will very well aid in the assessment of CRF.

Materials and Methods:
A cross-sectional study was conducted using convenience sampling on men aged 40–65 from the community of Ahmedabad. Six-minute walk test was used to assess CRF. All participants’ body mass index (BMI), waist circumference (WC), PA levels (Rapid Assessment of PA [RAPA]), fatigue levels (Fatigue Severity Scale [FSS]), depression, anxiety, and stress were analyzed. Regression analysis was done using the SPSS 20.0 version.

Results:
Sixty-five participants with a mean age of 53.48 ± 7.76 years participated in the study. The mean 6MWD was 486.6 ± 110.13 m. Association of 6MWD with BMI was 1%, with WC was 2.2%, with RAPA was 28.9%, with FSS was 45.8%, with depression was 23.6%, with anxiety was 31.4%, and with stress was 38.1%.

Conclusion:
CRF of middle-aged men was found to be low. BMI and WC had minimal effect while PA levels, fatigue levels, depression, anxiety, and stress levels had an influence on CRF. Further studies should be designed to improve the factors affecting CRF in middle-aged men.
Giant Lumbosacral Extradural Intraosseous Schwannoma in an Adolescent Male – A Rare Lesion
Authors: Kharosekar Hrushikesh Umakant , Kumar Shrijit , Saurabh Saket , Velho Vernon 
Published: September 2024

Abstract
Schwannoma are benign slow growing tumor arising from Schwann cells of the nerve sheaths of peripheral nerves. Giant spinal schwannomas are defined as lesions that extend over more than two vertebral levels or have extraspinal extension of more than 2.5 cm. They are usually intradural, Extradural giant spinal schwannomas in the adolescent age group is of rare. Only 5 cases of purely extradural giant spinal schwanomma have been reported in literature. We report a purely extradural giant schwanomma and its management.
Comparative Analysis of Platelet-rich Plasma and Triamcinolone Acetonide Injections in the Management of Plantar Fasciitis: A Prospective Study
Authors: Gaurav Abhishek , Shroff Abhijit , Pisal Tushar , Patel Hetal Yogeshbhai 
Published: September 2024

Abstract

Context:
Plantar fasciitis, a prevalent cause of heel pain, poses challenges in treatment due to diverse therapeutic options and variable outcomes. Platelet-rich plasma (PRP) and triamcinolone acetonide (TA) injections have emerged as potential interventions, yet their comparative effectiveness remains debated.

Aims:
The aim of the study was to compare the effectiveness of PRP and TA injections in relieving pain, improving function, and promoting healing in individuals with plantar fasciitis.

Settings and Design:
The study design was a prospective, hospital-based, experimental study.

Subjects and Methods:
A 2-year prospective hospital-based experimental study was conducted, enrolling patients aged 30–60 years with plantar fasciitis. Patients received either PRP or TA injections. Preoperative assessments and 3 months of monitoring were performed. Foot and Ankle Outcome Score (FAOS) survey was utilized for outcome evaluation.

Statistical Analysis Used:

T-test was applied.

Results:
Ninety patients were included, with both treatment groups demonstrating significant improvement in foot symptoms. PRP administration showed superiority in descending and ascending stairs, rising from sitting, and walking on flat surfaces compared to TA. FAOS scores indicated significant improvement posttreatment in both groups, with PRP yielding better outcomes than TA.

Conclusions:
Both PRP and TA injections effectively alleviate foot symptoms in plantar fasciitis patients. However, PRP demonstrates superior outcomes in specific functional activities and quality-of-life components compared to TA. These findings suggest PRP as a preferred intervention in the management of plantar fasciitis.
Evaluating the effects of humor therapy on fatigue levels of hemodialysis patients: A single-blind, randomized clinical trial study
Authors: Sahebkar Mohammad , Ansari Mojgan , Attarzadeh Farnush , Borzoee Fateme 
Published: September 2024

Background:
This study investigated the effects of humor therapy on the fatigue levels of patients receiving hemodialysis (HD).

Materials and Methods:
A single-blind, randomized clinical trial of 66 HD patients for 3 weeks was conducted, in which two groups were randomly allocated – humor therapy and control. In the intervention group, humor therapy sessions were conducted twice a week for 3 weeks. As a pre- and postintervention assessment, the Fatigue Symptom Inventory (FSI) was completed.

Results:
According to the repeated-measures ANOVA test, FSI values exhibited a significant decline in the humor therapy group and an increase in the control group at the first, second, and third visits (humor therapy vs. control: 30.38 ± 8.75 and 61.80 ± 13.92, P < 0.001; 35.71 ± 10.05 and 69.53 ± 15.32, P < 0.001; and 34.85 ± 9.24 and 70.34 ± 22.26, P < 0.001, respectively) compared with baseline (humor therapy vs. control: 49.26 ± 5.19 and 52.09 ± 11.69, P = 0.204).

Conclusion:
Findings suggest that humor therapy can effectively reduce fatigue levels in patients presenting with HD.
Evaluation of sleep quality in stage II and stage III colorectal cancer patients–secondary analysis of a randomized controlled trial
Authors: D’Souza Anita R. , Chaudhari Jyoti , Ostwal Vikas , Ramaswamy Anant , Bhargava Prabhat 
Published: September 2024

Abstract

Background:
Sleep quality in cancer patients often does not receive sufficient attention from their treating physicians and nurses. This report aims to highlight this under-researched issue among colorectal cancer patients scheduled to receive adjuvant chemotherapy.

Materials and Methods:
This is a secondary analysis of data from 129 participants from a randomized controlled trial conducted to determine the nurse-led intervention’s effect on cognitive and non-cognitive functions and serum TNF-alpha levels in patients receiving chemotherapy for colorectal cancer at Tata Memorial Hospital. The Pittsburgh Sleep Quality Index was used to collect data on sleep quality. The study also explored potential reasons for the reported poor sleep quality in the selected cohort.

Results:
The prevalence of poor sleep quality was approximately 60%. Sleep was primarily affected due to poor sleep latency and sleep efficiency. Also, women were more likely to experience issues related to sleep. Patients did not consider it a significant issue to report to their treating physicians and nurses. Factors contributing to poor sleep quality included financial concerns, child-rearing responsibilities, and anxiety about disease outcomes.

Conclusion:
Cancer patients do experience poor sleep quality, and it is crucial to assess and address this issue promptly to prevent adverse responses to cancer therapy, which can lead to increased morbidity and mortality.
Revolutionizing medicine practice using stem cells in healthcare: review article
Authors: Acharya Prajnashree , Nyamagoud Sanatkumar B. 
Published: September 2024

Abstract
This review delves into the transformative potential of stem cells in healthcare, particularly within regenerative medicine. With their unique ability to self-renew and differentiate into various cell types, stem cells offer groundbreaking possibilities for treating various medical conditions. The review begins by thoroughly exploring different types of stem cells, from totipotent to pluripotent, highlighting their specific capabilities. This foundational understanding sets the stage for examining the therapeutic potential of stem cells. A key focus is the practical application of stem cell-based therapies, particularly in treating conditions like epidermolysis bullosa and macular degeneration. These examples showcase how stem cell research translates into real-world treatments, helping individuals with debilitating illnesses regain functionality and improve their quality of life. The review further emphasizes advancements in clinical trials, particularly in neurodegenerative diseases and spinal cord injuries, demonstrating significant progress in these fields. Additionally, the importance of stem cell banking is underscored as an essential resource for future regenerative medicine, offering a readily available source of cells for personalized treatments. Integrating stem cell research into therapeutic applications represents a revolutionary leap in modern medicine, potentially disrupting traditional treatment paradigms and providing new hope for previously incurable diseases.
Study of histopathological spectrum of ovarian tumors in a tertiary care hospital in India
Authors: Subramaniyan Mahalakshmi , Shrinivas Arathi , Hasabi Vidya , Mary Anne , Reddy Purushotham 
Published: September 2024

Abstract

Background:
Ovarian tumors rank as the third leading cause of mortality among female genital tract malignancies. This study examined the histopathological spectrum of ovarian neoplasms based on our center’s 2020 World Health Organization (WHO) classification.

Materials and Methods:
This descriptive study was carried out over 5 years at our tertiary healthcare hospital, including 406 cases of ovarian neoplasms. After proper fixation and gross examination, sections were routinely processed and examined. The histopathological spectrum of ovarian neoplasms was analyzed according to the 2020 WHO classification.

Results:
Out of the 406 cases studied, 329 (81.03%) were benign, 65 (16.01%) were malignant, and 12 (2.95%) were borderline. The cases included 326 (80.29%) surface epithelial tumors, 58 (14.28%) germ cell tumors, 19 (4.68%) sex cord-stromal tumors, and 2 (0.49%) metastatic tumors. The majority of ovarian tumors (n = 340, 83.74%) occurred in the 20–60 years age group.

Conclusion:
The study reveals that benign tumors were more prevalent than malignant ones, with serous tumors being the most common among the benign cases. We observed a higher incidence of malignancy in women over the age of 40. Therefore, early and accurate histological diagnosis is crucial for initiating an appropriate management plan.
A study to assess the effectiveness of a structured teaching program on nursing students’ knowledge of euthanasia across different colleges in Navi Mumbai, India
Authors: Tike Shital Parag , Ghag Shweta 
Published: September 2024

Abstract

Background:
Euthanasia, derived from the Greek term meaning “good death,” involves ending a life to alleviate suffering, particularly in cases of terminal illness or severe pain. Legal views on euthanasia vary globally, with the Netherlands and Belgium leading by legalizing it in 2001 and 2002, respectively. In India, the 2011 Supreme Court ruling in the Aruna Shanbaug case permitted passive euthanasia under specific conditions, sparking ongoing debates about the legalization of euthanasia and physician-assisted suicide.

Materials and Methods:
This study used a quantitative research design with a pre-experimental one-group pretest and posttest approach. The study was conducted at selected Navi Mumbai colleges, including 108 students selected through nonprobability convenience sampling. A pretest was administered before the structured teaching program, which was then implemented. The students were reassessed 7 days later.

Results:
Among the 108 B.Sc. nursing students, pretest knowledge scores revealed that 34% had poor knowledge and 57% had average knowledge, indicating a moderate understanding of euthanasia. In contrast, posttest results showed that 59% of students demonstrated good knowledge, and 41% exhibited excellent knowledge. The mean pretest score of 7.19 increased to 14 in the posttest, highlighting that the structured teaching program significantly improved the students’ knowledge of euthanasia. No significant association was found between pre-intervention knowledge scores and selected demographic variables.

Conclusion:
Effective education can substantially enhance knowledge levels. The structured teaching program successfully improved students’ understanding of euthanasia, as they initially had a limited grasp of the topic.
Meta-analysis: Vidian Canal Length, Types, Dehiscence, and Relationship to Medial Pterygoid Plate
Authors: Kuriakose Santhosh , Nuveen A. K. , Revankar Sanjaykumar B. , Shetty Balakrishna , Shetty Sweekritha 
Published: September 2024

Abstract
Vidian canal (VC) as an anatomical landmark directs endoscopic approaches to the petrous carotid artery and the anteromedial part of the cavernous sinus, facilitating precise surgical access to these intricate regions. The objectives of this meta-analysis were to determine the normal range, pooled averages of VC length, and distance between VC and foramen rotundum (FR); to evaluate the proportion of different types of VC and proportion of dehiscent VC; and to report the relation of VC to medial pterygoid plate (MPP). Embase, Pubmed Central, and other databases were searched for the published articles reporting length, types, dehiscence of VC, relationship with MPP, distance between VC and FR. Prevalence data from individual study were tabulated, and 95% confidence intervals (CIs) were computed. A total of 203 studies were identified from the search. Excluding duplicates, 190 studies were screened for eligibility and 35 articles were selected. Excluding four studies for differential reporting of outcomes, 31 studies were considered for qualitative and quantitative analyses. Sixteen studies reported the length of VC. There was significant heterogeneity indicating variability in effect estimates across studies and this variability was due to difference between study population rather than random variation. The pooled average length of the VC was 14.93 (95% CI: 13.60–16.26). The pooled prevalence of Type 1, 2, and 3 VC was 31% (95% CI: 22%–40%), 43% (95% CI: 34%–51%), and 24% (95% CI: 14%–33%), respectively. The pooled prevalence of VC medial to MPP and on the same plane as that of MPP was 46% (95% CI: 25%–68%) and 48% (95% CI: 29%–67%), respectively.
The Effect of Average Value Mounting and Facebow Transfer on Condylar Guidance Settings in a Semi-Adjustable Articulator – A Comparative Study using Digital Lateral Cephalographs in Edentulous Patients
Authors: Mustafa MZ , Shetty G , Deeban Y , Mathar MI , Joseph AM , Aldhuwayhi S , Thakare AA , Al-Hamad KA , Shamsudeen SM , Ayub MS 
Published: September 2024

Background:
While we attempt to restore occlusion in completely edentulous patients there is a consensus among clinicians to articulate the cast using average value and avoid performing facebow transfer. Various studies question the application of facebow transfer in the fabrication of removable complete denture fabrication.

Aim:
This study was therefore aimed to study the effect on condylar guidance with casts mounted by the facebow method, Bonwill’s method, and radiographic method.

Methods:
A cross-sectional study was performed using casts of edentulous patients attending the Department of Prosthodontics. After establishing a tentative jaw relationship using wax occlusal rims in the edentulous participants, the casts were mounted by Bonwill’s method and the facebow transfer method to a semi-adjustable articulator. Protrusive records of the subjects were used to program the articulator to obtain the condylar guidance values. Digital lateral cephalographs were made both in centric and protrusive jaw relationships. The mandibular condyles were then traced and overlapped to obtain radiographic values. The condylar guidance values obtained by Bonwill’s method, facebow method and radiographic method were compared using Wilcoxon’s signed rank test and Mann–Whitney U test. The SPSS Statistics for Windows (Version 21.0. Armonk, NY, USA:IBM Corp.), and, at a probability value of 0.05, the significance of every statistical test was predetermined.

Results:
Ten edentulous 45–70 year olds participated in the study. The mean discrepancy between radiography and facebow methods was 12.8° for the right side and 12.7° for the left (P < 0.005). The difference between radiography and Bonwill’s methods was significant (P < 0.005), with a mean difference of 34.3° for the right side and 34.7° for the left side. The difference between Bonwill’s method and the facebow method was significant (P < 0.005), with a mean difference of 21.5° for the right side and 22° for the left side.

Conclusion:
The condylar guidance values obtained by clinical methods (Bonwill’s and Facebow) were significantly lesser (P < 0.005) compared to the values obtained by radiographic method.
The Effect of Tideglusib Application on Type 1 and Type 3 Collagen Expressions by Human Dental-Pulp Derived Stem Cells: A Preliminary Study
Authors: Güler C , Yilmaz AM , Kuru L , Ozen B , Agrali OB 
Published: September 2024

Background:
Although Tideglusib cytotoxicity studies and its effects on human dental pulp-derived stem cells (DPSCs) have been examined in previous studies, there is no study investigating the expression of type 1 collagen and type 3 collagen by Tideglusib.

Aim:
The purpose of this study is to examine the effect of Wnt signaling activation using Tideglusib execution on human DPSC to determine its potential efficacy in collagen expression.

Methods:
Stem cell isolation was performed from five human third molar wisdom tooth pulps. DPSCs identified in only one sample were treated with 50 nM Tideglusib for 24 h and 1 week. Axin-2, type 1 and type 3 collagen expressions were evaluated by Western blot analysis. DPSCs without treatment served as a negative control. The Mann-Whitney U test was used for statistical analysis.

Results:
The levels of type 1 collagen and Axin-2 in the test group were significantly higher than those in the control group at 24 h (P = 0.000, P = 0.001, respectively). Compared to the control group, a slight increase in type 3 collagen expression was observed in the test group at 24 h (P value = 0.063). Application of 50 nM Tideglusib for 1 week revealed marked decreases in type 1 and type 3 collagen expressions (P = 0.029, P = 0.038, respectively). In contrast, there was a significant increase in the level of Axin-2 (P = 0.000) compared to the control group.

Conclusion:
The fact that Wnt signaling pathway activation obtained by Tideglusib application on DPSCs confirmed by the finding in the increase of Axin-2 at short and long-term evaluation periods which is resulted in the increase in the type 1 collagen expression at 24 h and decrease at 1 week together with the decrease in type 3 collagen expression at 1 week warrants further studies to evaluate the effect of Tideglusib on extracellular matrix expression.
Reliability and Validity Study of the Migraine Interictal Burden Scale-4 in Turkish
Authors: Karaci Rahsan , Sünbül Esra Aydin , Dikmen Pinar Yalinay , Aydinlar Elif Ilgaz , Bilgiç Fehmi , Öksüz Nevra , Özçelik Emel Ur , Atalar Arife Çimen , Tasdelen Semih , Ekizoglu Esme , Uludüz Ezgi , Uludüz Derya , Özge Aynur , Domaç Füsun Mayda 
Published: September 2024

ABSTRACT

Objective:
The objective of this study was to assess the reliability and validity of the Turkish version of the Migraine Interictal Burden Scale-4 (MIBS-4) in patients with migraine. MIBS-4 measures migraine-related interictal burden in four domains related to difficulty in planning at work or school, family and social life, and emotional/affective and cognitive stress.

Materials and Methods:
A total of 178 patients with migraine were enrolled in this multicenter, prospective study in two consecutive interviews with 4-week intervals. The comprehensibility, patient–physician reliability, internal consistency, test–retest reliability, and validity of the Turkish translation of MIBS-4 were analyzed.

Results:
In terms of comprehensibility of all MIBS-4 questions, a statistically significant agreement was obtained between the patient and the physician (intraclass correlation coefficient [ICC] = 0.713; P < 0.001, ICC = 0.851; P < 0.001, ICC = 0.637; and P < 0.001, ICC = 0.760; P < 0.001). No statistically significant difference was found between the comprehensibility of the first, second, third, and fourth questions of MIBS-4 according to the patient self-test and the physician interviews (P = 0.167, P = 0.068, P = 0.121, and P = 0.225, respectively). A significant high consistency was obtained between the first and second interview values (ICC = 0.891; P < 0.001). Cronbach’s alpha coefficient was obtained between 0.818 and 0.845, and the scale was obtained with high reliability. A statistically significant positive correlation was obtained between the first and second interview MIBS values and Headache Impact Test-6, and the correlation coefficients were obtained as 0.158 and 0.330, respectively (P = 0.036 and P < 0.001, respectively).

Conclusion:
These results demonstrated that the Turkish translation of MIBS-4 is equivalent to the English version in terms of internal consistency, and it has high test–retest reliability and validity. The Turkish version of MIBS-4 can serve as a reliable, useful, and valid tool for assessing the burden on patients between migraine attacks, as well as aiding health-care professionals in enhancing migraine treatment strategies in Türkiye.
Antimyelin oligodendrocyte glycoprotein antibody positive optic neuritis mimicking as arteritic anterior ischemic optic neuropathy: A diagnostic dilemma
Authors: Shrinkhal  , Garg Pragati , Singh Swarastra Prakash , Kumar Pramod , Banerjee Nilakshi 
Published: September 2024

Abstract
We present here an interesting case of antimyelin oligodendrocyte glycoprotein antibody-positive atypical optic neuritis (ON) mimicking as arteritic anterior ischemic optic neuropathy. The aim of the report is to focus on the rare presentation of atypical ON which can create a diagnostic dilemma. The case focuses on the role of clinical acumen and an aggressive approach toward these cases.