bluuebunny/crossref_metadata_2025_split huggingface dataset:
BEBERAPA ASPEK PENTING DALAM BUDIDAYA UDANG VANAMEI (Litopenaeus vannamei ) DENGAN SISTEM PEMUPUKAN SUSULAN DI TAMBAK (TRADISIONAL PLUS)
Authors: Gunarto Gunarto 
Published: October 2016

Sebagian besar tambak di Indonesia dikelola secara tradisional oleh petambak yang rata-rata bermodal kecil. Untuk itu, teknologi budidaya udang vanamei pola tradisional plus perlu dikembangkan misalnya dengan sistem pemupukan susulan sehingga akan diperoleh teknologi budidaya yang murah tetapi menguntungkan bagi petambak tradisional. Beberapa faktor penting yang sangat perlu diperhatikan agar supaya berhasil dalam budidaya udang vanamei pola tradisional plus, di antaranya adalah persiapan tambak harus maksimal, pemilihan dan penanganan benur harus betul, kontruksi tambak meskipun untuk pola tradisional harus didisain agar air baru mudah masuk ke tambak dan air buangan beserta limbahnya dapat segera keluar dari pelataran tambak, cara pengelolaan air sistem resirkulasi atau penggantian air hanya dilakukan saat terjadi air pasang tinggi. Penggunaan fermentasi probiotik dan peningkatan upaya biosekuritas di sekitar lingkungan tambak. Dengan memperhatikan faktor-faktor penting tersebut, meskipun udangdipelihara pada musim kemarau dengan kadar garam tinggi (53--34 ppt) dengan hanya mengandalkan pemupukan susulan 750 g urea dan 375 g SP-36/500 m2 serta penambahan fermentasi probiotik sebanyak 3 mg/L per minggu ternyata masih bisa panen dengan masa pemeliharaan lebih singkat yaitu 76 hari. Produksi pada kepadatan 1, 3, 5, dan 7 ekor/m2 masing-masing pada kisaran 4,1--8,69 kg/500 m2 (82--173,8 kg/ha); 8,7--10,7 kg/500 m2 (174--214 kg/ha); 4,27--10,55 kg/500 m2 (175,6--211 kg/ha); dan 11,6--17,5 kg/500 m2 (232--350 kg/ha).
Księgozbiory radości, czyli o sztuce pisania, czytania i kompletowania bibliotek
Authors: Żardecka-Nowak Magdalena 
Published: October 2016

Tekst dotyczy przyjemności czytania, pisania i kompletowania bibliotek. Rozpoczyna się od krótkich rozważań terminologicznych na temat przyjemności i szczęścia. Następnie ukazuje Freudowską koncepcję zasady przyjemności i jej miejsce w życiu psychicznym człowieka. Przedstawia także Platoński mit o pochodzeniu pisma. Streszcza Lacana koncepcję języka oraz jej stosunek do podmiotowości i nieświadomości. Ukazuje Don Kichote’a jako przykład człowieka zaczytanego aż do obłędu. Przedstawia paradoksalny (ambiwalentny) charakter fascynacji tekstami. Ukazuje krajobraz po wieży Babel, pełen miłośników książek cieszących się z wielości i różnorodności języków i tekstów. Stawia pytanie, czy radość z obcowania z tekstami jest tylko pustą grą. W konkluzji odsyła do Ricoeura i jego koncepcji człowieka jako istoty poszukującej sensu. Sens okazuje się tym, czego oczekujemy. Przyjemność, jaką sprawiają czytanie i pisanie, jest przedsmakiem sensu.
Szczęście i radość jako rezultat kłamstwa
Authors: Wąż Paulina 
Published: October 2016

Fenomen szczęścia i kłamstwa dotyczy każdego uczestnika życia publicznego. Kłamstwo jest silną pokusą, ponieważ pozwala ułatwić realizację zamierzonego celu. Emocje negatywne i pozytywne mogą sprzyjać kłamstwu lub je demaskować. Do uczuć pozytywnych sprzyjających kłamstwu należą radość i szczęście z oszukiwania innych ludzi. Na przykładzie różnych rodzajów kłamstwa ukazane zostaną próby wywołania szczęścia i radości. Kłamstwo może wywołać szczęście, które będzie pozytywną emocją spowodowaną doświadczeniami, które oceniane są przez podmiot jako pozytywne, a mogą to być np. informacje. Gdy wkraczamy w sferę wewnętrznych przeżyć jednostki, mamy także wpływ na dalszy bieg jej życia. Chociaż niektóre kłamstwa wydają się nieszkodliwe i posługujemy się nimi codziennie, to należy mieć na uwadze, że kłamstwo zawsze ma „krótkie nogi” i wyjdzie na jaw. Dlatego poprzez kłamstwo nie jest możliwe uzyskanie szczęścia jako stanu trwałego, lecz jedynie jego momentu, chwilowej poprawy humoru czy zadowolenia. Niektórzy ludzie czerpią radość z plotki, dlatego też starają się ją powielać. Inni poprzez plotkę chcą wpłynąć na swoje otoczenie, szerząc informacje niepotwierdzone, by uzyskać zamierzone reakcje ludzi. Celem referatu jest wykazanie, że trzeba mieć na uwadze dobro drugiego człowieka i pamiętać, że oczekuje od nas prawdy, darzy nas zaufaniem. Kłamstwa nadużywa się w każdej sferze życia, jednak nawet dążenie do osiągnięcia szczęścia i radości czy też maksymalizacji szczęścia poprzez kłamstwo nie może być usprawiedliwieniem dla kłamcy.
Przyjemność jako źródło wspólnoty
Authors: Zieliński Wojciech Bartłomiej 
Published: October 2016

Zastanawiając się nad podstawą fundującą zbiorowość ludzką, sięga się myślą do prawa stanowionego, do wspólnej kultury, a tym samym przeszłości. Poszczególne narody przeglądają się w lustrze dziejów, szukając swego ducha. Wydaje się, że do szeregu tych propozycji można dopisać jeszcze jedną, mniej oczywistą: przyjemność. By przybliżyć tę kwestię, odwołamy się do koncepcji estetycznej Immanuela Kanta. Następnie wnioski z teorii królewieckiego myśliciela zostaną rozwinięte w kontekście stworzonym przez marksowską teorię wiedzy.Powstałe w ten sposób narzędzie niejako odsuwa na margines idee piękna czy dobra jako społecznotwórcze, a skupia się bardziej na rzeczywistości potocznej, dynamizując w ten sposób konstrukcję i jej podstawę.
Estudio documental del valle de Pardomino (León)
Authors: Álvarez Maurín María del Pilar 
Published: October 2016

<p>En este trabajo intentamos realizar un estudio de la vida religiosa en el valle de Pardomino, en el municipio de Boñar (León). El más antiguo documento conocido data del año 917 y confirma la existencia de actividad religiosa antes de esta fecha. La regla benedictina fue implantada más tarde e introdujo la vida conventual en el valle. El trabajo pretende determinar el numero de monasterios así como su probable localización a partir del análisis toponímico de los documentos y la identificación actual de los lugares.</p><p> </p><p>In this work we try to accomplish a study about the religious life in Pardomino Valley, in the surroundings of Boñar (León). The oldest document known is dated in the year 917 and it confirms the existence of religious activity before this date. The Benedictine rule was implanted later and brought the conventual existence to the Valley. The work pretends to determine the number of monasterios as well as their probable location based on the analysis of the documents and the present identification of the places.</p>
New Onshore Drilled Cuttings Treatment Facility Takes a Bold Environmental Initiative in Ghana
Authors: Zormelo Michael , Donkor Paul Yaw , Ametewee Selorm Alfred 
Published: October 2016

Abstract
The first major deepwater oil discovery was made in Ghana during 2007. Since then over 50 deepwater wells have been drilled by various operators using Low Toxicity Oil Based drilling fluids. Discharge of drilled cuttings to the ocean with residual oil on cuttings has been permitted in Ghana under the current regulatory regime. Current offshore cuttings drier technology will reduce residual oil on cuttings to low levels prior to discharge but not eliminate it completely.
Many other offshore drilling areas around the world operate a ‘zero discharge’ approach where no oil contaminated cuttings are permitted to be discharged overboard. In this case the cuttings are contained offshore before being shipped onshore for treatment. The oil is then removed and reused using thermal desorption or equivalent technology, the clean water is discharged and remaining clean cuttings are utilised in land fill sites or in some cases building products. These ‘Skip and ship’ methods require offshore cuttings handling equipment, a supply chain involving marine vessels and trucks for onshore cuttings transport. Most importantly it requires a specialised onshore treatment facility that will completely remove any residual oil on cuttings prior to disposal of the clean dry cuttings.
This paper will describe the component parts of a skip and ship method and how it would operate in a new deepwater oil province. It describes in detail how one service provider pre-emptively set up an onshore cuttings treatment facility in Ghana in readiness for future skip and ship operations. The detailed technical operation of the facility is described and technical and political learnings are offered.
The Zodiac Calendar and Equity Factor Returns
Authors: Phoeng Janice , Swinkels Laurens 
Published: October 2016

Abstract
We calculate the returns for four well-known equity return factors—market, size, value, and momentum—for each zodiac calendar year from 1927 to 2015. We find that the point estimates of average returns for each zodiac sign can be substantially different. However, when we employ statistical tests, we do not find enough evidence to reject the null hypothesis of equal excess returns across zodiac signs. For an investor with an equally weighted portfolio in these four equity factors, the Year of the Rooster may seem particularly good and the Year of the Ox particularly poor, but also in this case the null hypothesis cannot be rejected. Hence, we conclude that investment strategies based on zodiac signs are unlikely to generate superior returns.
Enzymatic Ugi Reaction with Amines and Cyclic Imines
Authors: Żądło‐Dobrowolska Anna , Kłossowski Szymon , Koszelewski Dominik , Paprocki Daniel , Ostaszewski Ryszard 
Published: October 2016

AbstractThe application of the Ugi reaction to the construction of new peptide scaffolds is an important goal of organic chemistry. To date, there are no examples of the Ugi reaction being performed with a cyclic imine and amine simultaneously. The application of 2‐substituted cyclic imines in an enzymatic three‐component Ugi‐type reaction provides an elegant and attractive synthesis of substituted pyrrolidine and piperidine derivatives in up to 60 % yield. Results on studies of the selection of an enzyme, amount of water, and solvent used in a novel three‐component Ugi reaction and the limitations thereof are reported herein. The presented methodology exploiting enzyme promiscuity in the multicomponent reaction fulfills the requirements associated with green chemistry. Several methods, such as isotope labeling and enzyme inhibition, were used to probe the possible mechanism of this complex synthesis. This research is the first example of an enzyme‐catalyzed Ugi‐type reaction with an imine, amine, and isocyanide.
Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies
Authors: Shibany Khaled A. , Tötemeyer Sabine , Pratt Stefanie L. , Paine Stuart W. 
Published: October 2016

AbstractDespite reports of the successful isolation of primary equine hepatocytes, there are no published data regarding the successful cryopreservation of these isolated cells. In this study, a detailed description of the procedures for isolation, cryopreservation, and recovery of equine hepatocytes are presented. Furthermore, the intrinsic clearance (Clint) and production of metabolites for three drugs were compared between freshly isolated and recovered cryopreserved hepatocytes. Primary equine hepatocytes were isolated using a two‐step collagenase perfusion method, with an average cell yield of 2.47 ± 2.62 × 106 cells/g of perfused liver tissue and viability of 84.1 ± 2.62%. These cells were cryopreserved with William's medium E containing 10% fetal bovine serum with 10% DMSO. The viability of recovered cells, after a 30% Percoll gradient, was 77 ± 11% and estimated recovery rate was approximately 27%. These purified cells were used to determine the in vitro Clint of three drugs used in equine medicine; omeprazole, flunixin, and phenylbutazone, via the substrate depletion method. Cryopreserved suspensions gave a comparable estimation of Clint compared to fresh cells for these three drugs as well as producing the same metabolites. This work paves the way for establishing a bank of cryopreserved equine hepatocytes that can be used for estimating pharmacokinetic parameters such as the hepatic metabolic in vivo clearance of a drug as well as producing horse‐specific drug metabolites.
Contrasting hydraulic strategies in Salix psammophila and Caragana korshinskii in the southern Mu Us Desert, China
Authors: Li Yangyang , Chen Weiyue , Chen Jiacun , Shi Hui 
Published: October 2016

AbstractSalix psammophila and Caragana korshinskii are two common shrubs in the southern Mu Us Desert, China. Their hydraulic strategies for adapting to this harsh, dry desert environment are not yet clear. This study examined the hydraulic transport efficiency, vulnerability to cavitation, and daily embolism refilling in the leaves and stems of these two shrubs during the dry season. In order to gain insight into water use strategies of whole plants, other related traits were also considered, including daily changes in stomatal conductance, leaf mass per area, leaf pressure–volume parameters, wood density and the Huber value. The leaves and stems of S. psammophila had greater hydraulic efficiency, but were more vulnerable to drought‐induced hydraulic dysfunction than C. korshinskii. The difference between leaf and stem water potential at 50 % loss of conductivity was 0.12 MPa for S. psammophila and 0.81 MPa for C. korshinskii. Midday stomatal conductance decreased by 74 % compared to that at 8:30 in S. psammophila, whereas no change occurred in C. korshinskii. Daily embolism and refilling occurred in the stems of S. psammophila and leaves of C. korshinskii. These results suggest that a stricter stomatal regulation, daily embolism repair in stems, and a higher stem water capacitance could be partially compensating for the greater susceptibility to xylem embolism in S. psammophila, whereas higher leaf elastic modulus, greater embolism resistance in stems, larger difference between leaf and stem hydraulic safety, and drought‐induced leaf shedding in C. korshinskii were largely responsible for its more extensive distribution in arid and desert steppes.
Controls on the transport of oceanic heat to Kangerdlugssuaq Glacier, East Greenland
Authors: COWTON TOM , SOLE ANDREW , NIENOW PETER , SLATER DONALD , WILTON DAVID , HANNA EDWARD 
Published: October 2016

ABSTRACTGreenland's marine-terminating glaciers may be sensitive to oceanic heat, but the fjord processes controlling delivery of this heat to glacier termini remain poorly constrained. Here we use a three-dimensional numerical model of Kangerdlugssuaq Fjord, East Greenland, to examine controls on fjord/shelf exchange. We find that shelf-forced intermediary circulation can replace up to ~25% of the fjord volume with shelf waters within 10 d, while buoyancy-driven circulation (forced by subglacial runoff from marine-terminating glaciers) exchanges ~10% of the fjord volume over a 10 d period under typical summer conditions. However, while the intermediary circulation generates higher exchange rates between the fjord and shelf, the buoyancy-driven circulation is consistent over time hence more efficient at transporting water along the full length of the fjord. We thus find that buoyancy-driven circulation is the primary conveyor of oceanic heat to glaciers during the melt season. Intermediary circulation will however dominate during winter unless there is sufficient input of fresh water from subglacial melting. Our findings suggest that increasing shelf water temperatures and stronger buoyancy-driven circulation caused the heat available for melting at Kangerdlugssuaq Glacier to increase by ~50% between 1993–2001 and 2002–11, broadly coincident with the onset of rapid retreat at this glacier.
Expression of the T85A mutant of zebrafish aquaporin 3b improves post-thaw survival of cryopreserved early mammalian embryos
Authors: Bedford-Guaus Sylvia J. , Chauvigné François , Mejía-Ramírez Eva , Martí Mercè , Ventura-Rubio Antoni , Raya Ángel , Cerdà Joan , Veiga Anna 
Published: October 2016

SummaryWhile vitrification has become the method of choice for preservation of human oocytes and embryos, cryopreservation of complex tissues and of large yolk-containing cells, remains largely unsuccessful. One critical step in such instances is appropriate permeation while avoiding potentially toxic concentrations of cryoprotectants. Permeation of water and small non-charged solutes, such as those used as cryoprotectants, occurs largely through membrane channel proteins termed aquaporins (AQPs). Substitution of a Thr by an Ala residue in the pore-forming motif of the zebrafish (Dario rerio) Aqp3b paralog resulted in a mutant (DrAqp3b-T85A) that when expressed inXenopusor porcine oocytes increased their permeability to ethylene glycol at pH 7.5 and 8.5. The main objective of this study was to test whether ectopic expression of DrAqp3b-T85A also conferred higher resistance to cryoinjury. For this, DrAqp3b-T85A + eGFP (reporter) cRNA, or eGFP cRNA alone, was microinjected intoin vivofertilized 1-cell mouse zygotes. Following culture to the 2-cell stage, appropriate membrane expression of DrAqp3b-T85A was confirmed by immunofluorescence microscopy using a primary specific antibody directed against the C-terminus of DrAqp3b. Microinjected 2-cell embryos were then cryopreserved using a fast-freezing rate and low concentration (1.5 M) of ethylene glycol in order to highlight any benefits from DrAqp3b-T85A expression. Notably, post-thaw survival rates were higher (P<0.05) for T85A–eGFP-injected than for -uninjected or eGFP-injected embryos (73±7.3 vs. 28±7.3 or 14±6.7, respectively). We propose that ectopic expression of mutant AQPs may provide an avenue to improve cryopreservation results of large cells and tissues in which current vitrification protocols yield low survival.
Cross-Cutting Exposure on Facebook and Political	Participation
Authors: Lu Yanqin , Gall Myrick Jessica 
Published: October 2016

Abstract. This experiment (N = 193) explores the effects of cross-cutting exposure via social media on two types of political participation. The results reveal that exposure to cross-cutting social media news can motivate cheap participation better than costly participation. Moreover, the mobilizing effects of cross-cutting exposure are mediated by anger and anxiety, as suggested by affective intelligence theory and appraisal theories of emotion. The mediating effects of anxiety are also moderated by online incivility. Implications are discussed in terms of the role of social media use and cross-cutting exposure in participatory democracies.
Paracrine Effects of Adipose-Derived Stem Cells on Matrix Stiffness-Induced Cardiac Myofibroblast Differentiation via Angiotensin II Type 1 Receptor and Smad7
Authors: Yong Kar Wey , Li Yuhui , Liu Fusheng , Bin Gao  , Lu Tian Jian , Wan Abas Wan Abu Bakar , Wan Safwani Wan Kamarul Zaman , Pingguan-Murphy Belinda , Ma Yufei , Xu Feng , Huang Guoyou 
Published: October 2016

AbstractHuman mesenchymal stem cells (hMSCs) hold great promise in cardiac fibrosis therapy, due to their potential ability of inhibiting cardiac myofibroblast differentiation (a hallmark of cardiac fibrosis). However, the mechanism involved in their effects remains elusive. To explore this, it is necessary to develop an in vitro cardiac fibrosis model that incorporates pore size and native tissue-mimicking matrix stiffness, which may regulate cardiac myofibroblast differentiation. In the present study, collagen coated polyacrylamide hydrogel substrates were fabricated, in which the pore size was adjusted without altering the matrix stiffness. Stiffness is shown to regulate cardiac myofibroblast differentiation independently of pore size. Substrate at a stiffness of 30 kPa, which mimics the stiffness of native fibrotic cardiac tissue, was found to induce cardiac myofibroblast differentiation to create in vitro cardiac fibrosis model. Conditioned medium of hMSCs was applied to the model to determine its role and inhibitory mechanism on cardiac myofibroblast differentiation. It was found that hMSCs secrete hepatocyte growth factor (HGF) to inhibit cardiac myofibroblast differentiation via downregulation of angiotensin II type 1 receptor (AT1R) and upregulation of Smad7. These findings would aid in establishment of the therapeutic use of hMSCs in cardiac fibrosis therapy in future.
Biomimetic carriers mimicking leukocyte plasma membrane to increase tumor vasculature permeability
Authors: Palomba R. , Parodi A. , Evangelopoulos M. , Acciardo S. , Corbo C. , de Rosa E. , Yazdi I. K. , Scaria S. , Molinaro R. , Furman N. E. Toledano , You J. , Ferrari M. , Salvatore F. , Tasciotti E. 
Published: October 2016

AbstractRecent advances in the field of nanomedicine have demonstrated that biomimicry can further improve targeting properties of current nanotechnologies while simultaneously enable carriers with a biological identity to better interact with the biological environment. Immune cells for example employ membrane proteins to target inflamed vasculature, locally increase vascular permeability and extravasate across inflamed endothelium. Inspired by the physiology of immune cells, we recently developed a procedure to transfer leukocyte membranes onto nanoporous silicon particles (NPS), yielding Leukolike Vectors (LLV). LLV are composed of a surface coating containing multiple receptors that are critical in the cross-talk with the endothelium, mediating cellular accumulation in the tumor microenvironment while decreasing vascular barrier function. We previously demonstrated that lymphocyte function-associated antigen (LFA-1) transferred onto LLV was able to trigger the clustering of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells. Herein, we provide a more comprehensive analysis of the working mechanism of LLV in vitro in activating this pathway and in vivo in enhancing vascular permeability. Our results suggest the biological activity of the leukocyte membrane can be retained upon transplant onto NPS and is critical in providing the particles with complex biological functions towards tumor vasculature.
Computer keyboard interaction as an indicator of early Parkinson’s disease
Authors: Giancardo L. , Sánchez-Ferro A. , Arroyo-Gallego T. , Butterworth I. , Mendoza C. S. , Montero P. , Matarazzo M. , Obeso J. A. , Gray M. L. , Estépar R. San José 
Published: October 2016

AbstractParkinson’s disease (PD) is a slowly progressing neurodegenerative disease with early manifestation of motor signs. Objective measurements of motor signs are of vital importance for diagnosing, monitoring and developing disease modifying therapies, particularly for the early stages of the disease when putative neuroprotective treatments could stop neurodegeneration. Current medical practice has limited tools to routinely monitor PD motor signs with enough frequency and without undue burden for patients and the healthcare system. In this paper, we present data indicating that the routine interaction with computer keyboards can be used to detect motor signs in the early stages of PD. We explore a solution that measures the key hold times (the time required to press and release a key) during the normal use of a computer without any change in hardware and converts it to a PD motor index. This is achieved by the automatic discovery of patterns in the time series of key hold times using an ensemble regression algorithm. This new approach discriminated early PD groups from controls with an AUC = 0.81 (n = 42/43; mean age = 59.0/60.1; women = 43%/60%;PD/controls). The performance was comparable or better than two other quantitative motor performance tests used clinically: alternating finger tapping (AUC = 0.75) and single key tapping (AUC = 0.61).