bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Andersson lesion-complicating ankylosing spondylitis via early minimally invasive surgery
Authors: Zhang Chenggui , Li Yang , Wang Guodong , Sun Jianmin 
Published: October 2024

AimsA variety of surgical methods and strategies have been demonstrated for Andersson lesion (AL) therapy. In 2011, we proposed and identified the feasibility of stabilizing the spine without curettaging the vertebral or discovertebral lesion to cure non-kyphotic AL. Additionally, due to the excellent reunion ability of ankylosing spondylitis, we further came up with minimally invasive spinal surgery (MIS) to avoid the need for both bone graft and lesion curettage in AL surgery. However, there is a paucity of research into the comparison between open spinal fusion (OSF) and early MIS in the treatment of AL. The purpose of this study was to investigate and compare the clinical outcomes and radiological evaluation of our early MIS approach and OSF for AL.MethodsA total of 39 patients diagnosed with AL who underwent surgery from January 2004 to December 2022 were retrospectively screened for eligibility. Patients with AL were divided into an MIS group and an OSF group. The primary outcomes were union of the lesion on radiograph and CT, as well as the visual analogue scale (VAS) and Oswestry Disability Index (ODI) scores immediately after surgery, and at the follow-up (mean 29 months (standard error (SE) 9)). The secondary outcomes were total blood loss during surgery, operating time, and improvement in the radiological parameters: global and local kyphosis, sagittal vertical axis, sagittal alignment, and chin-brow vertical angle immediately after surgery and at the follow-up.ResultsData for 30 patients with AL were evaluated: 14 in the MIS group and 16 in the OSF group. All patients were followed up after surgery; no nonunion complications or instrumentation failures were observed in either group. No significant differences in the VAS and ODI scores were identified between the two groups. Mean ODI improved from 51 (SE 5) to 17 (SE 5) in the MIS group and from 52 (SE 6) to 19 (SE 5) in the OSF group at the follow-up. There were significant improvements in total blood loss (p = 0.025) and operating time (p < 0.001) between the groups. There was also no significant difference in local kyphosis six months postoperatively (p = 0.119).ConclusionEarly MIS is an effective treatment for AL. MIS provides comparable clinical outcomes to those treated with OSF, with less total blood loss and shorter operating time. Our results support and identify the feasibility of solid immobilization achieved by posterior instrumentation without bone graft via MIS for the treatment of AL.Cite this article: Bone Jt Open 2024;5(10):886–893.
A Method for Detecting the Death State of Caged Broilers Based on Improved Yolov5
Authors: Cao Chong , Zhang Wanchao , Chen Changxi , Kong Xiangchao , Wang Qi , Deng Zhuangzhuang 
Published: October 2024

HighlightsRapid and accurate identification and detection of mortality in high-level caged broilers.Apply the state-of-the-art single-stage object detection model Yolov5 as the experimental infrastructure.Modify and improve the network structure, reduce the calculation amount of model parameters, and make the model easier to deploy.The data of dead broilers in different regions can also be quickly and accurately identified and detected, with excellent generalization.Abstract. In an unmanned broiler base, the automatic identification of the death state of broilers in a complex cage environment can effectively improve picking efficiency and reduce its negative impact. An improved Yolov5 object detection method is proposed in this study to rapidly and accurately detect the presence of dead broilers in caged structures. The Yolov5 model within the CSPDarknet53 framework is constructed, and the Yolov5 model is experimentally pruned to reduce the number of convolution kernels. The Ghost structure and the Involution structure are combined with the Yolov5 backbone network to effectively reduce the number of parameters and computations with a negligible loss of accuracy, making it easier to deploy applications. The detection accuracy of the model can reach 99.2%. The number of parameters is reduced from 7.05M to 0.31M, and the amount of calculation is reduced from 16.3 to 0.3. It can be seen that the improved Yolov5 network is practical and suitable for high-precision real-time detection and recognition of the death state of broilers in a caged structure. Keywords: Keywords.,Computer vision, Dead chicken detection, Machine vision, Yolov5.
Simultaneous generation of dual 16-QAM-modulated millimeter-wave signals enabled by precoding-based optical I/Q modulation and single photodetector detection
Authors: Bi Jiahao , Xie TangYao , Li Xinying , Pan Xiaolong , Yan Hengxin , Fang Liye , Xu Yuxiao , Lin Qiuying , Zhu Jianping , Xin Xiangjun 
Published: October 2024

Integration of quadrature-amplitude-modulation (QAM) modulation and millimeter-wave (mm-wave) technology ensures a concise enhancement of transmission capacity and peak data rates in radio-over-fiber (RoF) systems. Nevertheless, with the continuous development of new-generation mobile applications, higher demands on access flexibility have also been formulated. We propose a novel, to the best of our knowledge, dual 16-QAM-modulated mm-wave signal generation scheme for the simultaneous generation and transmission of two independent 16-QAM signals with different carrier frequencies, enhancing the channel capacity, spectrum efficiency, and access flexibility of the RoF systems. In our proposed scheme, the generation of the optical dual 16-QAM-modulated mm-wave signals is implemented by a precoding-based optical in-phase/quadrature (I/Q) modulator operating at optical carrier suppression (OCS) mode, and their detection is implemented by a single photodetector (PD). At the transmitter side, two independent driving QAM vector radio-frequency (RF) signals with precoding, generated via digital signal process (DSP), are fed into two parallel Mach–Zehnder modulators (MZMs) of an I/Q modulator to implement OCS modulation. The I/Q modulator generates optical carriers carrying both information from different QAM signals simultaneously. After square-law detection in a single PD, we generate the desired dual 16-QAM-modulated mm-wave signals with photonic frequency-doubling and recover the original 16-QAM signals without information distortion. Based on our proposed scheme, we experimentally demonstrate the simultaneous generation and transmission of 2-Gbaud dual 16-QAM-modulated mm-wave signals with carrier frequencies of 26 GHz and 40 GHz, respectively. After transmission over 10-km single-mode fiber (SMF) link and 1.2-m wireless link, the dual 16-QAM signals can be successfully separated and demodulated by a common DSP. Bit-error ratios (BERs) of both recovered 16-QAM signals can reach the hard-decision forward-error-correction (HD-FEC) threshold of 3.8×10−3. Compared with the existing schemes, our scheme only requires one-half of the driving frequency to generate dual 16-QAM-modulated mm-wave signals with the same carrier frequency. The result indicates that our proposed scheme can lower bandwidth requirements for optoelectronics devices, along with implementing better spectral efficiency and receiver sensitivity, which is more applicable to the demands for increased system capacity and multi-frequency access flexibility in future systems.
Gut-microbiome profiles among Soil-transmitted helminths (STHs) infected Ethiopian children enrolled in the school-based mass deworming program
Authors: Taye Bineyam , Mekonnen Zeleke , Belanger Kenneth D. , Davenport Emily R. 
Published: October 2024

Background
Soil-transmitted helminths (STHs) and mutualistic gut microbes coexist in the gastrointestinal tract. However, limited data exist regarding how STH infections are associated with gut microbiome profiles.

Method
We conducted a cross-sectional analysis of baseline data collected in a longitudinal study to identify and explain differences in microbial communities between STH-infected and non-infected Ethiopian school children. We collected 138 stool samples and analyzed them for STH infection using standard direct wet mount and Kato Katz methods. The gut microbiome profiles were characterized using targeted amplicon sequencing of the 16S rRNA gene from the total DNA extracted from the stools.

Results
Children infected with Trichuris trichiura showed significantly lower microbial diversity than those who were non-infected (p<0.05). We also observed significant difference in microbiome composition based on Trichuris trichiura infection status (PERMANOVA p< 0.01). A comparison of microbial taxa at the genus level among participants infected with different helminth species showed a significant increase in Agathobacter relative abundance among children infected with Trichuris trichiura compared to non-infected subjects (adjusted p = 0.001).

Conclusions
Our results indicate that changes in the gut microbiome composition may vary depending on the species of helminth present. Further studies should investigate how Trichuris trichiura selectively alters microbiome composition compared to other STH species.
Diabetes self-care intervention strategies and their effectiveness in Sub-Saharan Africa: A systematic review
Authors: Ageru Temesgen Anjulo , Le Cua Ngoc , Wattanapisit Apichai , Woticha Eskinder Wolka , Truong Nam Thanh , Stanikzai Muhammad Haroon , Abiso Temesgen Lera , Suwanbamrung Charuai 
Published: October 2024

Background
Diabetes poses a significant public health challenge, predominantly affecting low-and middle-income countries (LMICs), including in Sub-Saharan Africa (SSA). The evolving landscape characterized by resource constraints, gaps in availability and functionality of healthcare system, and socio-demographic impediments has compounded these challenges. As an example, self-care interventions have played a crucial role in diabetes care. However, the effectiveness of these interventions in the SSA remains insufficiently explored. Therefore, this systematic review evaluated the effectiveness and implementation approach of diabetes self-care interventions in SSA.

Method
A comprehensive search was conducted across electronic databases including PubMed, Scopus, and Google Scholar, to identify studies focusing on diabetes self-care interventions in SSA from 2013 to 2023. The included studies reported interventions targeting dietary adherence, physical activity, medication adherence, blood glucose monitoring, foot care, and educational or support programs. The quality of the studies was assessed using the JBI checklist. Effectiveness was assessed through outcomes including glycemic control, adherence rate, complication reduction, and improvement in patient outcomes.

Result
Overall, 38.5% of interventions result showed positive changes in either primary or secondary outcomes. Studies that employed diabetes self-management education showed positive changes in approximately 28.6% of cases. However, SMS text messaging interventions did not demonstrate significant changes in the measured outcomes.
Of the 13 studies reviewed, 12 used randomized controlled trial designs, whereas one study employed a quasi-experimental approach. The total of participants across intervention and control groups was 3172 adults with diabetes. The interventions employed various strategies including diabetes self-management education led by nurses and other professionals, SMS text messaging for treatment adherence, and other targeted approaches. The duration of these interventions varied from 2 to 12 months. Specific interventions, such as glucose machine provision with training, family support with culturally tailored educations, and periodontal treatment, exhibited notable improvement in adherences and reductions in HbA1c levels.

Conclusion
The review underscores the significance of diabetes self-care interventions in SSA, showing varying effectiveness levels across different strategies. It emphasizes the importance of tailored approaches and highlight interventions that have shown promising outcomes, providing insights for future research, policy, and healthcare strategies in the region.
Cardiovascular health of women 10 to 20 years after placenta-related pregnancy diseases considering the possible effect of pentaerythrityl tetranitrate treatment during pregnancy on long-term maternal cardiovascular health (PAVA study)
Authors: Lößner Charlotte , Multhaup Anna , Bäz Laura , Lehmann Thomas , Heimann Yvonne , Schleußner Ekkehard , Franz Marcus , Groten Tanja 
Published: October 2024

Background
Women developing preeclampsia (PE) or fetal growth restriction (FGR) during pregnancy are at higher risk for cardiovascular diseases (CVD) later in life. We aimed to analyse cardiovascular health of women 10–20 years after affected pregnancies in comparison to women after uneventful pregnancies. In addition, we assessed a potential long-term effect of the NO-donor pentaerythrityl tetranitrate (PETN).

Methods
Women 10–20 years after severe PE, including women receiving PETN during pregnancy and matched controls were recruited and assessed for baseline clinical data and cardiovascular function by transthoracic echocardiography, VICORDER and USCOM. SPSS was used for statistical analysis.

Results
53 participants after PE/FGR (13 with former PETN intake) and 51 controls were recruited for follow-up at an average of 14 years after index pregnancies. Compared to controls, women after PE/FGR had a significantly higher incidence of arterial hypertension (13.7% vs. 41.5%, p<0.001), and were more likely to be hypertensive (41.2% vs. 67.30%, p = 0.008). There were no differences in cardiovascular function observed. Affected women with PETN intake during pregnancy showed lower mean values for right atrial area and ventricle in comparison to controls and also to affected women without former medication.

Conclusions
In conclusion, our study results confirm that the risk of CVD is increased in women after PE/FGR compared to women after uneventful pregnancies. Contrary to our expectations, no major cardiovascular changes were observed in our cohort 10–20 years post pregnancy. The observed differences found in right heart dimensions were within reference ranges, and should be interpreted with caution.
Orthosilicic acid inhibits human osteoclast differentiation and bone resorption
Authors: Magnusson Catarina , Ransjö Maria 
Published: October 2024

Context
Silicon (Si), which is present in the diet in the bioavailable form of orthosilicic acid (OSA) and is detected as a dissolution product of certain bone-substitute materials, is suggested to promote bone health, and enhance bone healing, respectively. Silicon has been shown to stimulate osteoblastic cell differentiation and function, although the effect of Si on human osteoclasts is unclear.

Aim
The present study investigated the direct effects of Si on human osteoclast differentiation, gene expression, and bone resorption.

Material & methods
Human CD14+ monocytes were isolated from buffy coats and cultured with M-CSF and RANKL in medium without or with Si (50 μg/ml; constituting 75% OSA). The effects of Si on osteoclast differentiation were evaluated by TRAP-staining and the expression levels of CtsK, CalcR, TRAP, and DC-STAMP measured by RT-qPCR. The effect of Si on the expression level of AQP9, which encodes a potential Si transporter, was also analyzed. Bone resorption was determined based on the number of resorption pits formed when the RANKL-stimulated monocytes were cultured on bone slices, and by the levels of type I collagen fragments released into the cell culture medium.

Results
Silicon significantly inhibited the number of TRAP+ multinucleated cells and the expression of osteoclast related genes but increased the late expression of AQP9. Furthermore, Si significantly inhibited the number of resorption pits and the amount of collagen fragments in the medium when cells were cultured on bone slices.

Conclusion
Our results demonstrate that OSA inhibits RANKL-stimulated human osteoclast differentiation, gene expression of osteoclast phenotypic markers, and bone resorption.
A Case of Immune Checkpoint Inhibitor–Induced Duodenitis
Authors: Au Sandra , Chen Wei , Vance Iris , Wegermann Kara 
Published: October 2024

ABSTRACT
Immune checkpoint inhibitors improve patient survival in multiple cancers, but immune-related adverse events, including new immunologic conditions arising during therapy, pose a significant challenge. Gastrointestinal immune-related adverse events, although common, exhibit diverse presentations. We present a case of duodenitis resembling celiac disease because of the anti–programmed cell death protein-1 antibody, pembrolizumab. Despite diagnostic uncertainty and therapeutic interventions, including gluten-free diet, symptoms stabilized even with resuming gluten. In addition, endoscopic abnormalities after pembrolizumab therapy have neither progressed nor completely resolved. This case underscores the need for investigation into the pathogenesis of immune checkpoint inhibitor–induced duodenitis, with implications for care of patients on immunotherapies.
Metastatic Small Cell Carcinoma of the Stomach
Authors: Gunay Mirac , Leone Celia , Albayati Oksana , Mohamed Abdalla , Anyadike Nnaemeka 
Published: October 2024

ABSTRACT
Primary gastric small cell carcinoma (GSCC) is an extremely rare type of small cell carcinoma. Its aggressive nature with early widespread metastasis and late detection gives it a poor prognosis with overall survival of <12 months. GSCC is a type of neuroendocrine tumor, and because of its histopathological similarity to small cell lung carcinoma (SCLC), treatment regimen of GSCC includes the same chemotherapy agents as SCLC. We report a case of a 57-year-old man who presented with signs of partial gastrointestinal obstruction and was found to have a primary stage IV GSCC with metastasis to the liver.
Impact of disclosing a working diagnosis during simulated patient handoff presentation in the emergency department: correctness matters
Authors: Amano Masayuki , Harada Yukinori , Shimizu Taro 
Published: October 2024

Abstract

Objectives
Diagnostic errors in emergency departments (ED) are a significant concern and exacerbated by cognitive biases during patient handoffs. The timing and accuracy of disclosing working diagnoses during these handoffs potentially influence diagnostic decisions, yet empirical evidence remains limited.

Materials and Methods
This parallel, quasi-experimental study involved 40 interns from Japanese teaching hospitals, randomly assigned to control or intervention groups. Each group reviewed eight audio-recorded patient handoff scenarios where working diagnoses were disclosed at the start (control) or end (intervention). Four cases presented correct diagnoses, while four featured incorrect ones. The main measure was diagnostic error rate, calculated as the proportion of incorrect post-handoff responses to total questions asked.

Results
No significant difference in diagnostic error rates emerged between the control (39.4 %, 63/160) and intervention (38.8 %, 62/160) groups (point estimate −0.6 %; 95 % CI: −11.3–10.1 %, p=0.91). However, a substantial difference was evident between diagnostic errors after correct (20.6 %, 33/160) and incorrect (57.5 %, 92/160) working diagnoses presented (point estimate: 36.9 %; 95 % CI: 27.0–46.8 %, p<0.001). Diagnostic momentum accounted for 52 % (48/92) of errors under incorrect diagnoses.

Conclusions
While the timing of working diagnosis disclosure did not significantly alter diagnostic accuracy during ED handoffs, exposure to incorrect diagnoses markedly increased error rates. These findings underscore the imperative to refine diagnostic skills and reconsider ED handoff protocols to mitigate cognitive biases and optimize patient care outcomes.
Acetylation of wood: understanding the risk of de-acetylation during exposure to elevated temperature
Authors: Slabohm Maik , Emmerich Lukas , Valkonen Mikko Juhani , Rautkari Lauri , Militz Holger 
Published: October 2024

Abstract
Acetylation is a breakthrough in wood modification and has been established on industrial scale. However, concerns have been raised regarding the stability of acetylated wood under elevated temperatures, particularly during post hot-pressing processes to manufacture products such as laminated veneer lumber (LVL). At around 150 °C, the added acetyl groups might cleave off (“de-acetylation”) and by that release sorption sites for water. This would increase the moisture uptake of the modified wood. In this study, the impact of hot-pressing at 150 °C on the stability of acetylated beech veneers and LVL was investigated. Fourier transform infrared (FTIR) spectroscopy showed that the chemical composition of acetylated veneers seemed to be unaffected after the heat treatment. Dynamic vapor sorption (DVS) analysis and long-term storing over saturated salt-solutions in miniature climate chambers, indicated no de-acetylation on the basis of negligible changes in wood-water interactions. The number of hydroxyl groups of heat-treated acetylated samples was similar to that of not heat-treated ones, indicating the persistence of the effects of acetylation. By the present study, a certain resilience of acetylated wood towards elevated temperature, like it may occur during hot-pressing of acetylated veneers, became apparent and illustrated the thermal stability of this chemical modification approach.
Antenatal corticosteroids for late small-for-gestational-age fetuses
Authors: Sgayer Inshirah , Hassan Sondos , Sarhan Talal , Ashkar Nadine , Lowenstein Lior , Wolf Maya Frank 
Published: October 2024

Abstract

Objectives
To compare neonatal morbidity in late preterm pregnancies with small-for-gestational-age fetuses, between those exposed and not exposed to antenatal corticosteroids (ACS).

Methods
A retrospective study which included growth-restricted fetuses delivered at gestational week 34+0 to 36+6 weeks at a tertiary university-affiliated hospital, from March 2016 to March 2022. The primary composite outcome included the need for oxygen therapy or ventilation, respiratory distress syndrome, transient tachypnea of the newborn, bronchopulmonary dysplasia, necrotizing enterocolitis, intraventricular hemorrhage grade III/IV and neonatal mortality.

Results
The primary composite outcome was comparable between those who did and did not receive ACS (26.1 vs. 20.8 %, p=0.512). Neonatal morbidity rates did not differ significantly between the groups, except for hypoglycemia, which was more common among neonates from ACS-exposed mothers (37.0 vs. 19.5 %, p=0.037). Multivariate analysis, adjusted for gestational diabetes and the mode of delivery showed no significant difference in the composite outcome between the groups (OR=2.03, 95 % CI 0.79–5.20, p=0.142). Cesarean delivery was associated with a higher risk of the primary outcome (OR=2.13, 95 % CI 1.17–3.85, p=0.013). After excluding those who did not receive the initial betamethasone dose within 2–7 days before delivery, the primary composite outcome remained similar between the groups. The primary composite outcome was similar among severely growth-restricted fetuses (<5th percentile) exposed and not exposed to ACS (29.2 vs. 22.0 %, p=0.560).

Conclusions
Among preterm pregnancies complicated by small-for-gestational-age fetuses, ACS did not lower the rate of neonatal morbidity.
Characterization of continuous additive set-valued maps “modulo K” on finite dimensional linear spaces
Authors: Jabłońska Eliza 
Published: October 2024

Abstract
Let Y be a real vector metric space and K ⊂ Y be a closed convex cone such that K ∩ (− K) = {0}. We prove that a convex compact-valued map F : ℝ → 2
Y
∖ {∅} is K-continuous and K-additive if and only if there are non-empty convex compact sets A, B ⊂ Y such that 0 ∈ A − B ⊂ K and F is equal “modulo K” to the continuous set-valued map

G
(
t
)
=

t
A
,

t
≥
0
,

t
B
,

t
<
0.

$$\begin{array}{}
\displaystyle
G(t)=\begin{cases}
tA,&t\geq0,\\
tB,& t \lt 0.
\end{cases}
\end{array}$$

Next, we use this result to characterize convex compact-valued maps F : ℝ
N
→ 2
Y
∖ {∅}.