bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the Late Cretaceous‐Cenozoic Structural Evolution of the North Peruvian Forearc System
Authors: Espurt N. , Brusset S. , Baby P. , Henry P. , Vega M. , Calderon Y. , Ramirez L. , Saillard M. 
Published: December 2017

AbstractThe link between plate tectonics and the evolution of active margins is still an ongoing task to challenge since the acceptance of plate tectonic paradigm. This paper aims at deciphering the structural architecture and uplift history of the North Peruvian forearc system to better understand the evolution and the mechanics that govern the Late Cretaceous‐Cenozoic building of this active margin. In this study, we report surface structural geology data, interpretation of seismic reflection profiles, apatite fission track data, and the construction of two offshore‐onshore crustal‐scale balanced cross sections. The structure of the North Peruvian forearc system is dominated by an accretionary style with northwestward propagation of thrust‐related structural highs involving continental/oceanic basement rocks and off‐scrapped sediments. The thrust systems bound thick thrust‐top forearc depocenters mainly deformed by crustal normal to strike‐slip faults and thin‐skinned gravitational instabilities. The sequential restoration of the margin calibrated with apatite fission track data suggests a correlation between uplift, shortening, and plate convergence velocity during Late Cretaceous and Miocene. Pliocene‐Quaternary shortening and uplift of the coastal zone is rather related to the subduction of asperities during convergence rate decrease. The development of crustal normal to strike‐slip faulting and subsidence zones might be the consequence of slab flexure, local basal erosion along subduction fault, and/or oblique subduction associated with sediment loading control. We conclude that the evolution of the North Peruvian forearc system was controlled by subduction dynamics, strong sediment accumulation, and recent ridge subduction, and it recorded the orogenic loading evolution of the Andes over the Cenozoic.
Synthesis of In‐Plane Artificial Lattices of Monolayer Multijunctions
Authors: Chiu Kuan‐Chang , Huang Kuan‐Hua , Chen Chun‐An , Lai Ying‐Yu , Zhang Xin‐Quan , Lin Erh‐Chen , Chuang Meng‐Hsi , Wu Jenn‐Ming , Lee Yi‐Hsien 
Published: December 2017

AbstractRecently, monolayers of van der Waals materials, including transition metal dichalcogenides (TMDs), are considered ideal building blocks for constructing 2D artificial lattices and heterostructures. Heterostructures with multijunctions of more than two monolayer TMDs are intriguing for exploring new physics and materials properties. Obtaining in‐plane heterojunctions of monolayer TMDs with atomically sharp interfaces is very significant for fundamental research and applications. Currently, multistep synthesis for more than two monolayer TMDs remains a challenge because decomposition or compositional alloying is thermodynamically favored at the high growth temperature. Here, a multistep chemical vapor deposition (CVD) synthesis of the in‐plane multijunctions of monolayer TMDs is presented. A low growth temperature synthesis is developed to avoid compositional fluctuations of as‐grown TMDs, defects formations, and interfacial alloying for high heterointerface quality and thermal stability of monolayer TMDs. With optimized parameters, atomically sharp interfaces are successfully achieved in the synthesis of in‐plane artificial lattices of the WS2/WSe2/MoS2 at reduced growth temperatures. Growth behaviors as well as the heterointerface quality are carefully studied in varying growth parameters. Highly oriented strain patterns are found in the second harmonic generation imaging of the TMD multijunctions, suggesting that the in‐plane heteroepitaxial growth may induce distortion for unique material symmetry.
In Situ Electrical Properties’ Investigation and Nanofabrication of Ag/Sb2Te3 Assembled Multilayers’ Film
Authors: Wu Zhenhua , Chen Xiang , Zhang Yan , Dun Chaochao , Carroll David L. , Hu Zhiyu 
Published: December 2017

AbstractNanopatterned fabrication and electrical properties of Ag/Sb2Te3 layer‐by‐layer assembled films are systematically investigated by a conductive atomic force microscope. Multilayers’ film composed by alternating Ag and Sb2Te3 with respective thicknesses of 5 and 10 nm shows a bipolar resistive switching behavior contributed by the silver conductive filaments. Designed cross‐plane nanofilament arrays with reconfigurable patterns are fabricated, which show a potential application in memristor and nanofabrication. Multilayers with the same thickness of Ag but increased thickness of Sb2Te3 (up to 20 nm) present a Fowler–Nordheim tunneling‐dominated current and show in‐plane snowflake silver dendrite on the surface. Further studies on the silver dendrite may bring potential applications in extensive fields such as multifunctional data storage and neuromorphic. By controlling the type (Sb2Te3, Bi2Te3, etc.) and thickness of solid electrolyte materials, electronic devices with specific functions and applications can be designed.
Oxidative Catalytic Spiroketalization Leading to Diastereoselective Synthesis of Spiro[benzofuran‐2,1′‐isochromene]s
Authors: Qiu Jiang‐Kai , Hao Wen‐Juan , Li Guigen , Jiang Bo 
Published: December 2017

AbstractA new one‐pot, two‐step silver‐catalyzed spiroketalization of the in‐situ generated quinone imine ketals (QIKs) with β‐alkynyl ketones has been established, enabling multiple C−O and C−C bond‐forming reactions to access densely functionalized spiro[benzofuran‐2,1′‐isochromene] derivatives with generally good yields. The use of β‐alkynyl ketones bearing alkyl and aryl groups located at the α‐position of the carbonyl group could lead to highly diastereoselective spiro[chromane‐2,1′‐isochromene] derivatives. The reaction features broad substrate scope, mild oxidative catalytic conditions and excellent diastereoselectivity.magnified image
Barium Bismuth Niobate Double Perovskite/Tungsten Oxide Nanosheet Photoanode for High‐Performance Photoelectrochemical Water Splitting
Authors: Weng Baicheng , Grice Corey R. , Ge Jie , Poudel Tilak , Deng Xunming , Yan Yanfa 
Published: December 2017

AbstractRecently, a new method to effectively engineer the bandgap of barium bismuth niobate (BBNO) double perovskite was reported. However, the planar electrodes based on BBNO thin films show low photocurrent densities for water oxidation owing to their poor electrical conductivity. Here, it is reported that the photoelectrochemical (PEC) activity of BBNO‐based electrodes can be dramatically enhanced by coating thin BBNO layers on tungsten oxide (WO3) nanosheets to solve the poor conductivity issue while maintaining strong light absorption. The PEC activity of BBNO/WO3 nanosheet photoanodes can be further enhanced by applying Co0.8Mn0.2Ox nanoparticles as a co‐catalyst. A photocurrent density of 6.02 mA cm−2 at 1.23 V (vs reversible hydrogen electrode (RHE)) is obtained using three optically stacked, but electrically parallel, BBNO/WO3 nanosheet photoanodes. The BBNO/WO3 nanosheet photoanodes also exhibit excellent stability in a high‐pH alkaline solution; the photoanodes demonstrate negligible photocurrent density decay while under continuous PEC operation for more than 7 h. This work suggests a viable approach to improve the PEC performance of BBNO absorber‐based devices.
Surgical outcomes of laparoscopic distal gastrectomy compared to open distal gastrectomy: A retrospective cohort study based on a nationwide registry database in Japan
Authors: Yoshida Kazuhiro , Honda Michitaka , Kumamaru Hiraku , Kodera Yasuhiro , Kakeji Yoshihiro , Hiki Naoki , Etoh Tsuyoshi , Miyata Hiroaki , Yamashita Yuichi , Seto Yasuyuki , Kitano Seigo , Konno Hiroyuki 
Published: December 2017

AbstractTo clarify the safety profile of laparoscopic distal gastrectomy (LDG) for gastric cancer patients, the short‐term outcome of LDG was compared to that of open distal gastrectomy (ODG) by propensity score matching using data from the Japanese National Clinical Database (NCD). We conducted a retrospective cohort study of patients undergoing distal gastrectomy between January 2012 and December 2013. Using the data for 70 346 patients registered in the NCD, incidences of mortality and morbidities were compared between LDG patients and ODG patients in the propensity score matched stage I patients (ODG: n = 14 386, LDG: n = 14 386) and stage II‐IV patients (ODG: n = 3738, LDG: n = 3738), respectively. There was no significant difference in mortality rates between LDG and ODG at all stages. Operating time was significantly longer in LDG compared to ODG, whereas blood loss and incidences of superficial surgical site infection (SSI), deep SSI, and wound dehiscence were significantly higher in ODG at all stages. Interestingly, pancreatic fistula was found significantly more often in LDG (1%) compared to ODG (0.8%) (P = .01) in stage I patients; however, it was not different in stage II‐IV patients. The length of postoperative stay was significantly longer in patients undergoing ODG compared to LDG at all stages. LDG in general practice might be a feasible therapeutic option in patients with both advanced gastric cancer and those with early gastric cancer in Japan.
Gram‐Scale Synthesis and Highly Regioselective Bromination of 1,1,9,9‐Tetramethyl[9](2,11)teropyrenophane
Authors: Unikela Kiran Sagar , Roemmele Tracey L. , Houska Václav , McGrath Kaitlin E. , Tobin David M. , Dawe Louise N. , Boeré René T. , Bodwell Graham J. 
Published: December 2017

AbstractAn improved synthetic pathway to the nanobelt‐like 1,1,9,9‐tetramethyl[9](2,11)teropyrenophane has been developed, and enables the synthesis of gram quantities of material. Key innovations are the development of a sequential chlorination/Friedel–Crafts alkylation reaction, a sequential iodination/Wurtz coupling reaction, and a room‐temperature teropyrene‐forming reaction. The teropyrenophane was found to form a very stable radical cation and undergo a completely regioselective fourfold bromination reaction.
Synthesis, spectroscopic evaluation, molecular modelling, thermal study and biological evaluation of manganese(II) complexes derived from bidentate N,O and N,S donor Schiff base ligands
Authors: Bargujar Savita , Chandra Sulekh , Chauhan Reeta , Rajor Hament K. , Bhardwaj Jyoti 
Published: December 2017

Manganese(II) complexes having the general composition Mn(L)2X2 (where L = 3‐bromoacetophenone semicarbazone, 3‐bromoacetophenone thiosemicarbazone, 1‐tetralone semicarbazone, 1‐tetralone thiosemicarbazone, flavanone semicarbazone or flavanone thiosemicarbazone and X = Cl− or ½SO42−) were synthesized. All the complexes were characterized using elemental analyses, molar conductance and magnetic moment measurements, and mass, 1H NMR, infrared, electron paramagnetic resonance and electronic spectral studies. The molar conductance of the complexes in dimethylsulfoxide lies in the range 10–20 Ω−1 cm2 mol−1 indicating their non‐electrolytic nature. All the complexes show magnetic moments corresponding to five unpaired electrons. The possible geometries of the complexes were assigned on the basis of electron paramagnetic resonance, electronic and infrared spectral studies. Some of the synthesized ligands and their complexes were screened for their antifungal activities against fungi Macrophomina phaseolina, Botrytis cinerea and Phoma glomerata using the food poison technique and their antibacterial activities against Xanthomonas campestris pv. campestris and Ralstonia solanacearum using the paper disc diffusion method. They showed appreciable activities.
Hierarchical TiO2 nanosheet‐assembled nanotubes with dual electron sink functional sites for efficient photocatalytic degradation of rhodamine B
Authors: Zhang Chao , Zhou Yuming , Bao Jiehua , Zhang Yiwei , Zhao Shuo , Fang Jiasheng , Chen Wenxia , Sheng Xiaoli 
Published: December 2017

A novel Pt–TiO2/Ag nanotube photocatalyst has been synthesized successfully via a facile method. TiO2 nanotubes are assembled with numerous ultrathin TiO2 nanosheets and show a highly open structure. The gaps between adjacent TiO2 nanosheets can serve as channels for the access of reactants, accelerating the mass transfer process. During the fabrication process of the Pt–TiO2/Ag nanotube photocatalyst, high‐quality Pt–SiO2 nanotubes are synthesized first with the structure‐directing effect of polyvinylpyrrolidone. Then a TiO2 layer is coated on the outside surface of the silica nanotubes. The introduced titanium species can be converted into TiO2 nanosheet structure during the subsequent hydrothermal treatment, gradually constructing nanosheet‐assembled nanotubes. Lastly, after the introduction of another electron sink function site of Ag through UV irradiation, the Pt–TiO2/Ag nanotube photocatalyst with dual electron sink functional sites is obtained. The specially doped Pt and Ag NPs can simultaneously inhibit the recombination process of photogenerated charge carriers and increase light utilization efficiency. Therefore, the as‐synthesized Pt–TiO2/Ag nanotube catalyst exhibits a high photocatalytic degradation performance for rhodamine B of 0.2 min−1, which is about 3.2 and 5.3 times as high as that of Pt–TiO2 and TiO2 nanotubes because of the enhanced charge carrier separation efficiency. Furthermore, in the unique nanoarchitecture, the nanotubes are assembled with numerous ultrathin TiO2 nanosheets, which can absorb abundant active species and dye molecules for photocatalytic reaction. On the basis of experimental results, a possible rhodamine B degradation mechanism is proposed to explain the excellent photocatalytic efficiency of the Pt–TiO2/Ag nanotube photocatalyst.
Dibenzothienopyrrolo[3,2‐b]pyrrole: The Missing Member of the Thienoacene Family
Authors: Tasior Mariusz , Czichy Małgorzata , Łapkowski Mieczysław , Gryko Daniel T. 
Published: December 2017

AbstractDibenzothienopyrrolo[3,2‐b]pyrrole and the corresponding bis(S,S‐dioxide) were synthesized by using a concise synthetic strategy. Despite the presence of six fused aromatic rings, π‐expanded pyrrolo[3,2‐b]pyrroles of this type absorb and emit at relatively short wavelengths, which reflects inefficient π conjugation due to the angular arrangement of the aromatic rings. They exhibit interesting and complex electrochemical behavior, which highlights their potential in organic electronics. Both heteroacenes undergo two‐stage oxidation while retaining the independence of each 1‐phenyl‐1H‐[1]benzothieno[3,2‐b]pyrrole, which was proved by in situ electron spin resonance measurements. Interestingly, electrochemically generated dicationdiradicals are not only distributed over the pyrrolo[3,2‐b]pyrrole scaffold, but also over the phenyl substituents located on nitrogen atoms.
Serum metabolomics of laryngeal cancer based on liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry
Authors: Zhang Xiaotao , Hou Hongwei , Chen Huan , Liu Yong , Wang An , Hu Qingyuan 
Published: December 2017

AbstractThe discovery of new laryngeal cancer‐related metabolite biomarkers could help to facilitate early diagnosis. A serum metabolomics study from laryngeal cancer patients and healthy individuals was conducted using liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry. Univariate and multivariate statistics were used to discriminate laryngeal cancer patients and healthy individuals. 1‐Palmitoyl‐sn‐glycero‐3‐phosphocholine (LysoPC 16:0), 1‐o‐hexadecyl‐2‐acetyl‐sn‐glycero‐3‐phosphocholine (PAF) and 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine were found to be significantly different between the laryngeal cancer group and the healthy group. They are mainly involved in phospholipids catabolism, linoleic acid metabolism, α‐linoleic acid metabolism and arachidonic acid metabolism. The area under the curve of the biomarker combined by two metabolites (LysoPC 16:0 and PAF) was 0.935, the sensitivity was 0.962 and the specificity was 0.825. LysoPC 16:0 and PAF may show diagnostic potential for laryngeal carcinoma.
Role of mitochondrial dysfunction in the pathophysiology of DNA repair disorders
Authors: Prates Mori Mateus , de Souza‐Pinto Nadja Cristhina 
Published: December 2017

AbstractDNA is constantly being damaged, either by endogenous or exogenous genotoxins. In that regard, DNA repair activities are essential for maintaining genomic stability and to life itself. Mutations in genes encoding DNA repair proteins cause severe human syndromes, but DNA repair defects have also been linked to several other diseases, notably to cancer and normal aging. Recently, new evidence has emerged indicating that some DNA repair diseases display mitochondrial and metabolic dysfunction through mechanisms that are yet being uncovered. These results suggest that mitochondria play an import role in the DNA damage response pathways and that damage accumulation may lead to mitochondrial dysfunction via metabolic imbalance and mitophagy impairment. Here we review the recent findings linking mitochondrial impairment and cell death to DNA damage accumulation in the context of DNA repair defects. In addition, the general involvement of DNA damage in cellular dysfunction suggests that these phenomena may be also involved in other human pathologies in which mitochondrial dysfunction and metabolic disruption play causative roles.
Regulation of osteogenesis of human amniotic mesenchymal stem cells by sodium butyrate
Authors: Fan Xiaoting , Li Lei , Ye Zhaoyang , Zhou Yan , Tan Wen‐Song 
Published: December 2017

AbstractHuman amniotic membrane‐derived mesenchymal stem cells (hAMSCs) draw great interests for regenerative medicine due to convenient availability and low immunogenicity. However, suboptimal culture conditions limit their application. In recent years, small molecules have proven powerful in regulating stem cell fates and can be applied to stimulate their function. In the present study, the impacts of sodium butyrate (NaBu), a histone deacetylase inhibitor (HDACi), on hAMSCs were investigated. It was shown that NaBu at a low concentration inhibited cell proliferation by arresting cell cycle at G0/G1 rather than inducing apoptosis. When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis‐related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. However, a higher concentration (1.0 mM) and longer exposure time (14 days) of NaBu showed no such effects, which may be partially attributed to both the increased expression of histone deacetylase 8 (HDAC8) and reduced level of H3K9‐Ace, thus leading to the transcriptional inhibition during osteogenesis. Further, it was indicated that ERK might be involved in the stimulatory effects of NaBu. These findings may be helpful to develop an efficient culture process for hAMSCs towards bone regeneration.
Emergency transcatheter closure of a stented PDA in a patient with pulmonary atresia and intact ventricular septum: be ready for the unexpected!
Authors: Faccini Alessia , Butera Gianfranco 
Published: December 2017

Key Clinical MessagePatients with congenital heart disease and duct‐dependent pulmonary circulation can undergo stenting of the patent ductus arteriosus (PDA). This case shows that, due to the physiological changes occurring after stent implantation, sometimes it is necessary to close the stented PDA rather than to redilate it.
Spontaneous pneumomediastinum in a term neonate – case report
Authors: Rocha Gustavo , Guimarães Hercília 
Published: December 2017

Key Clinical MessagePneumomediastinum after birth, without birth injury or resuscitation maneuvers, is an unusual situation that can present with grunting, deafening of cardiac sounds, and bulging of the hemithorax. If clinical condition allows, conservative approach is advised even if the pneumomediastinum does not spontaneously resolve in 1 or 2 days.
Is metformin poised for a second career as an antimicrobial?
Authors: Malik Faiza , Mehdi Syed Faizan , Ali Haroon , Patel Priya , Basharat Anam , Kumar Amrat , Ashok Fnu , Stein Joanna , Brima Wunnie , Malhotra Prashant , Roth Jesse 
Published: December 2017

SummaryMetformin, a widely used antihyperglycaemic, has a good safety profile, reasonably manageable side‐effects, is inexpensive, and causes a desirable amount of weight loss. In 4 studies of patients with tuberculosis (1 prospective and 3 retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of proinflammatory cytokines and improved survival. Laboratory studies showed effectiveness of the drug on multiple pathogens, includingTrichinella spiralis,Staphylococcus aureus,Pseudomonas aeruginosa, hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. Metformin administration in humans and mice produced major changes in the composition of the gut microbiota. These recently discovered microbe‐modulating properties of the drug have led investigators to predict wide therapeutic utility for metformin. The recent easing in United States Food and Drug Administration (FDA) guidelines regarding administration of metformin to patients with kidney disease, and reduced anxiety about patient safety in terms of lactic acidosis, increase the probability of broadening of metformin's usage as a treatment of infectious agents. In this text we review articles pertinent to metformin's effects on microorganisms, both pathogens and commensals. We highlight the possible role of metformin in a wide range of infectious diseases and a possible expansion of its therapeutic profile in this field. A systematic review was done of PubMed indexed articles that examined the effects of metformin on a wide range of pathogens. Metformin was found to have efficacy as an antimicrobial agent in patients with tuberculosis. Mice infected withTrypanosomiasis cruzihad higher survival when also treated with metformin. The drugin vitrowas active againstT. spiralis,S. aureus,P. aeruginosa, and hepatitis B virus. In addition there is emerging literature on its role in sepsis. We conclude that metformin may have a potential role in the therapy for multiple infectious diseases. Metformin, in addition to its traditional effects on glucose metabolism, provides anti‐microbial benefits in patients with tuberculosis and in a very wide range of other infections encounters in vitro and in vivo.
Microglial modulation of neuronal activity in the healthy brain
Authors: York Elisa M. , Bernier Louis‐Philippe , MacVicar Brian A. 
Published: December 2017

ABSTRACTInvestigations on the role of microglia in the brain have traditionally been focused on their contributions to disease states. However, recent observations have now convincingly shown that microglia in the healthy brain are not passive bystanders, but instead play a critical role in both central nervous system development and homeostasis of synaptic circuits in the adult. Here, we review the various mechanisms by which microglia impact neuronal communication in the healthy adult brain, both by sensing nearby synaptic responses and by actively modulating neuronal function. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 593–603, 2018