bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature
Authors: Pakfetrat Atessa , Dalirsani Zohreh , Saghravanian Nasrollah , Anvari Kazem , Asalian Sajede , Salehi Armaghan , Taherizadeh Mahboobeh 
Published: October 2024

ABSTRACTObjectivesMetastasis to the oral soft tissues and jaw is rare and accounts for 1%–3% of maxillofacial malignancies. These lesions usually occur in the context of an extensive malignant tumor with a poor prognosis.Materials and MethodsArchived cases from the Oral and Maxillofacial Pathology Department of the Faculty of Dentistry and two hospital centers of Mashhad University of Medical Sciences were examined. Inclusion criteria were cases with available records of pathologically confirmed metastatic lesions of the oral cavity with or without diagnosed primary malignancy.ResultsMetastatic lesions in the oral cavity and jaw were found in 18 patients, including seven women and 11 men, with a mean age of 49.5 years. Metastatic lesions were more common in the jaw (66%) and particularly in the mandible (38%) than elsewhere. In the case of soft tissue metastases, the gingiva was more affected than other sites. The primary tumor was most commonly in the kidney in men and in the breast in women (36%–28%). In addition, the diagnosis of a metastatic lesion led to the detection of the primary tumor elsewhere in six out of 18 cases (33.3%).ConclusionsEarly diagnosis of the lesions is challenging, given the absence of specific signs or symptoms, which, in some cases, nonetheless resemble inflammatory, benign, reactive lesions. Therefore, dentists play a crucial role in diagnosing such lesions, as they lead to the discovery of hidden distant primary tumors. Biopsy should always be considered for suspicious lesions, even if the probability is very low.
The role of turfgrasses in environmental protection and their benefits to humans: Thirty years later
Authors: Braun Ross C. , Mandal Parul , Nwachukwu Emmanuel , Stanton Alex 
Published: October 2024

AbstractBeard and Green compiled one of the earliest reviews on the environmental and societal (cultural) benefits that living turfgrass systems (e.g., home lawns, athletic fields, golf courses, roadsides, and grounds) provide to humans and associated contemporary issues with turfgrass. Today, the benefits of vegetation systems are called ecosystem services, and the associated negative aspects are called disservices. Since 1994, a significant amount of research has been conducted to further understand these ecosystem services and disservices and discover new ecosystem services and disservices, which we summarize and identify the knowledge gaps in this review. Turfgrass systems provide positive economic benefits to the US economy and help increase property values; however, many of these ecosystem services are environmental and societal. Some environmental services include (1) improving soil health, quality, and stability; (2) oxygen production; (3) reducing stormwater runoff; (4) filtering water to protect waterways and recharging groundwater; (5) providing evaporative cooling and reducing sunlight glare to improve human comfort levels; (6) offering vertebrate and invertebrate habitat; and (7) offering solutions for recycling wastewater and biosolids. Some societal (cultural) services include (1) outdoor spaces that improve human mental and physical health, (2) increasing community and social harmony, (3) helping deter crime, and (4) reducing human contact with noxious weeds and human‐disease insect vectors. Research, cooperative extension, and education efforts must be increased on these topics to continue to provide additional evidence of these ecosystem services to the public, policymakers, turfgrass practitioners, homeowners, students, and future generations.
Spatiotemporal characteristics of eustachian tube development in C57BL/6 mice: Correlation between morphological and functional maturation
Authors: Yu Xuan , Zhang Huimin , Li Hejie , Shen Xingqian , Yu Wenting , Li Ting , Chen Xiaoye , Zong Shimin , Xiao Hongjun 
Published: October 2024

AbstractBackgroundThe eustachian tube (ET), a critical conduit connecting the middle ear and nasopharynx, is essential for normal middle ear function. However, it remains one of the least understood anatomical structures due to its complexity and the challenges of in vitro manipulation. Historically, these challenges have hindered research into the morphology and function development of the ET. This study elucidates the spatiotemporal relationship of ET morpho‐functional maturation in mice, identifying key periods and factors that lay the theoretical foundation for exploring the molecular mechanisms of ET‐related diseases.ResultsWe comprehensively characterized the ET development in C57BL/6 mice from embryonic day (E) 12.5 to postnatal day (P) 30, focusing on the development of cilia, secretory cells, surrounding glands, and macrophages. Immunostaining identified the localization and secretion patterns of the mucins Muc5b and Muc5ac within the ET. Additionally, using improved ET function assessment tools, we evaluated the developmental features of ET mucociliary clearance and ventilation functions.ConclusionsIn C57BL/6 mice, E16.5 marks a critical period for middle ear cavity and ET formation. Muc5b plays a foundational role during early stages, while Muc5ac enhances function in later stages. During P7‐11, despite morphological maturity, ET function remains underdeveloped but continues to improve with growth.
Acute Activity Urges Predict Lower Early Weight Gain During Inpatient Treatment for Anorexia Nervosa
Authors: Halbeisen Georg , Amin Lina , Braks Karsten , Huber Thomas J. , Paslakis Georgios 
Published: October 2024

ABSTRACTEarly weight gain is a primary goal in the treatment of anorexia nervosa (AN) and associated with more favorable discharge weights and clinical outcomes. Activity urges, that is, a motivational state to engage in activity, have been suspected to delay early weight gain, but their prognostic role remains barely explored. Here, we investigated whether acute (state‐like) activity urges at treatment onset would predict within‐person weight gain in patients with AN during the initial 2 weeks of inpatient treatment. Adults with AN from an inpatient unit (N = 53) completed an activity urges measure at treatment onset, and weight changes were monitored for the duration of their treatment. Regression analyses, controlling for admission body mass index and other patient variables (i.e., patient age and AN subtype), found that higher state activity urges were associated with lower initial weight gain. Mediation analyses showed that differences in early weight changes further linked higher activity urges at admission to lower discharge weights. An activity urge cutoff value of 2.76 for distinguishing between cases with optimal and suboptimal initial weight gain is proposed. We discuss potential mechanisms of the link between activity urges and early weight gain and the implications of activity urges as a prognostic factor for improving weight restoration during AN treatment.
Performance of the novel ANTWERP score in predicting heart function improvement after atrial fibrillation ablation in Asian patients with heart failure
Authors: Ling Lo‐Chieh , Chang Ting‐Yung , Lin Yenn‐Jiang , Lin Chin‐Yu , Chang Shih‐Lin , Lo Li‐Wei , Hu Yu‐Feng , Chung Fa‐Po , Chen Shih‐Ann 
Published: October 2024

AbstractBackgroundPrevious research has demonstrated that atrial fibrillation (AF) ablation improves heart function variably among patients. We proposed that the ANTWERP score, which was validated in a European group of patients with low left ventricular ejection fraction (LVEF) who had AF ablation, would be valid in an Asian group as well. The purpose of the study is to examine how well a new scoring system (the ANTWERP score) can predict heart function improvement after atrial fibrillation ablation in Asian patients with heart failure.MethodsA retrospective review was conducted on patients (n = 84) undergoing AF ablation between January 2019 and June 2022. Initial diagnoses for impaired LV systolic function were confirmed by echocardiography. Patients meeting the “2021 Universal Definition of HF” criteria for LVEF recovery were classified as “responders.”ResultsSimilarities were observed between responders and nonresponders regarding comorbidities, AF type, and LVEF, except for the left ventricular internal diameter in diastole. A higher percentage of responders had an ANTWERP score ≤2 (87.8%) compared to those with a score >2 (55.6%). LVEF improvement was notably higher in the former group (+14.8% vs. +9.4%, p = .043). Atrial reverse remodeling and recurrent atrial arrhythmia rates were similar across groups.ConclusionThe conclusion of the study was that the ANTWERP score effectively predicted LVEF improvement after atrial fibrillation ablation in the Asian population and that this scoring system could be used to guide clinical decisions and prognosis prediction.
Growth, Yield and Grain Quality of Cowpea (Vigna unguiculata (L.) Walp.) and Weed Flora as Affected by Physical and Chemical Methods of Weed Control
Authors: Dennis Asare Osei , Santo Kwadwo Gyasi , Khalid Abdul Aziz , Atakora Kwabena , Ntiamoah Daniel Afreh , Abdulai Muntala , Eric Adjei 
Published: October 2024

ABSTRACTThis study sought to identify the most effective weed control methods for enhancing growth, yield and grain quality in cowpea and to reduce weed interference during the major and minor rainy seasons of 2022 at Juaso in the Asante Akim South Municipality, Ghana. Sun‐zema at 30 mL/15 L of water, Supremo (90 mL/15 L of water), Vezir (90 mL/15 L of water), Ogyama (100 mL/15 L of water) and Benfop (100 mL/15 L of water), hoeing, cutlass weeding and no weeding were evaluated in a randomized complete block design with three replicates. Data on weed flora, plant height, number of leaves per plant, days to 50% flowering and pod formation, grain yield and yield components and proximate composition of cowpea grains were collected and subjected to analysis of variance using GenStat statistical package (11th edition). Differences in means were compared using the Fisher's protected least significant difference at a probability level of 5%. Significant (p < 0.05) improvements in the growth of cowpea due to hoe weeding were observed. Hoeing, Vezir and Supremo herbicides increased grain yield during the major rainy season, with hoeing recording the highest value (0.53 ± 0.07 ton/ha), whereas Supremo herbicide recorded the highest grain yield (0.38 ± 0.06 ton/ha) during the minor season. Hoeing recorded the least grain moisture contents of 7.45 ± 0.62% and 6.35 ± 0.62% in the major and minor seasons, respectively, which could enhance postharvest handling. Application of Supremo, Sun‐zema and Ogyama reduced weed diversity in the study area. The study recommends hoeing during the major season and herbicide application (Supremo) during the minor season.
Effect of Ta–TiO2 Nanoparticles in Anion Exchange Membranes: Improved Hydroxide Ion Conductivity and Mechanical Strength for Alkaline Water Electrolysis Cells
Authors: Mahmoud Ahmed Mohamed Ahmed , Miyatake Kenji , Tsujii Kaito , Kakinuma Katsuyoshi , Liu Fanghua , Yadav Vikrant , Xian Fang , Guo Lin , Wong Chun Yik , Iwataki Toshio , Uchida Makoto 
Published: October 2024

AbstractTo improve the properties of quaternized QPAF‐4 copolymers as anion exchange membranes, compositing with hydrophilic Ta–TiO2 particles are investigated. Flexible QPAF‐4/Ta–TiO2 composite membranes are obtained using solution‐casting and die coating methods. Cross‐sectional scanning electron microscopy reveals that the die coating method produces a more homogenous and uniform distribution of Ta–TiO2 particles in the composite membranes than the solution‐casting method. The Ta‐TiO2 particles promotes the suppression of water absorbability and dimensional swelling of the composite membranes which is more pronounced in the die coated membranes. The Ta–TiO2 increase hydroxide ion conductivity to 116.9 mS cm−1 at 80 °C for the die‐coated membrane, surpassing that of the pristine QPAF‐4 membrane (92 mS cm−1). Ta–TiO2 with the composite membranes survive in 4 m KOH at 80 °C for 1000 h, maintaining 96–112 mS cm−1 (88–99% remaining) of initial conductivity. All composite membranes exhibit higher mechanical robustness (elongation of >200%), with the die‐coated composite membranes. The optimized die coated composite membrane is fabricated in an alkaline water electrolysis cell achieving 1.63 V at 1.0 A cm−2 (75.5% efficiency).
NIR‐II Image‐Guided Wound Healing in Hypoxic Diabetic Foot Ulcers: The Potential of Ergothioneine‐Luteolin‐Chitin Hydrogels
Authors: Yang Yao , He Shengnan , Wang Wumei , Lu Yiwen , Ren Bingtao , Dan Ci , Ji Yang , Yu Rui , Ju Xinpeng , Qiao Xue , Xiao Yuling , Cai Jie , Hong Xuechuan 
Published: October 2024

AbstractHypoxic diabetic foot ulcers (HDFUs) pose a challenging chronic condition characterized by oxidative stress damage, bacterial infection, and persistent inflammation. This study introduces a novel therapeutic approach combining ergothioneine (EGT), luteolin (LUT), and quaternized chitosan oxidized dextran (QCOD) to address these challenges and facilitate wound healing in hypoxic DFUs. In vitro, assessments have validated the biosafety, antioxidant, and antimicrobial properties of the ergothioneine‐luteolin‐chitin (QCOD@EGT‐LUT) hydrogel. Furthermore, near‐infrared II (NIR‐II) fluorescence image‐guided the application of QCOD@EGT‐LUT hydrogel in simulated HDFUs. Mechanistically, QCOD@EGT‐LUT hydrogel modulates the diabetic wound microenvironment by reducing reactive oxygen species (ROS). In vivo studies demonstrated increased expression of angiogenic factors mannose receptor (CD206) and latelet endothelial cell adhesion molecule‐1 (PECAM‐1/CD31), coupled with decreased inflammatory factors tumor necrosis factor‐α (TNF‐α) and Interleukin‐6 (IL‐6), thereby promoting diabetic wound healing through up‐regulation of transforming growth factor β‐1 (TGF‐β1).
Emerging Technologies for Improving Musculoskeletal Health: A Systematic Evidence Gap Map
Authors: Tanner Louise , Still Madeleine , Ghasri Soheila , Sadiq Adetutu , Harris Bethan , Haston Shona , Potter Rhiannon , Uteh Cyril Onwuelazu , Al‐Assaf Aalya , Johnson Eugenie Evelynne , Moral Sonia Garcia Gonzalez , Mkwashi Andrew , Craig Dawn , Angadji Arash , Thomas Martin , Pearson Fiona 
Published: October 2024

ABSTRACTIntroductionMusculoskeletal (MSK) conditions are the largest contributor to disability worldwide. The aim of this project was to undertake a horizon scan and generate an evidence gap map (EGM) to highlight technological innovations in development for preventing and managing MSK conditions at early stages of the clinical treatment pathway, and to identify areas of unmet need.MethodsIn February 2024, bibliographic databases, a clinical trial registry, research funding portals, and company websites were searched for relevant records. Identified records were screened for relevance; they had to be a device or digital “innovative” technology for maintaining or recovering positive musculoskeletal health in adults. The characteristics of relevant technologies, delivery setting and outcomes assessed were coded. An EGM was generated to illustrate the results. Methods followed Cochrane Rapid Reviews Guidance to ensure robustness.ResultsOne hundred and nine relevant technologies were identified. Nearly half (49.5%) of these technologies were designed for use at home. Most (50.5%) were digital technologies (e.g., mobile apps) or devices with a digital component (19.3%) (e.g., digital pain reduction kit). The impact of these technologies was most assessed by changes seen in measures of pain and mobility.Discussion and ConclusionThe proportion of technologies used at home compared to other settings indicates a shift in the setting of therapy provision for individuals with MSK conditions. Future evaluative studies should consider measuring a broader set of outcome domains in order to understand the direct and wider impacts of health technologies for those with MSK conditions.
Nerve conduction studies of sensory nerves with proven vasculitic neuropathy often show an absent electrical response
Authors: Becker Benjamin E. , London Zachary N. , Conway Kyle S. , Davalos Long 
Published: October 2024

AbstractIntroduction/AimsIn vasculitic neuropathy (VN), it is not known whether nerve conduction studies (NCSs) showing low amplitude sensory nerve action potentials (SNAPs) or those with absent responses have a higher yield in detecting appropriate nerves for pathological confirmation. Our goal was to describe NCS findings of nerves prior to biopsy in patients with VN.MethodsWe performed a retrospective study between January 2000 and April 2021 in patients with VN who either met pathological definite criteria for VN or criteria for clinically probable VN and had NCS of the sural or superficial radial sensory nerves prior to biopsy of the same nerve.ResultsWe included 61 patients with VN. The pathological findings showed 37 (60.7%) definite, 14 (23%) probable, and 2 (3.3%) possible VN; eight (13%) samples did not meet Peripheral Nerve Society pathological criteria. Most patients who met definite (20 out of 37, 54%) and probable (9 out of 14, 64%) VN pathological criteria had absent SNAPs. Only three out of eight (37.5%) patients without VN pathological findings had absent SNAPs. There was no statistically significant correlation between pathological diagnosis and SNAP amplitude (χ2 = 1.98, p = .58). Additionally, no association was found between VN pathological criteria and use of immunomodulatory treatment (p = .67) or corticosteroids (p = .52).DiscussionMost nerves with pathological VN findings showed no response on NCS. In patients with suspected VN, sural or superficial radial sensory nerves with absent responses on NCS are adequate biopsy targets as compared to nerves in which SNAPs can be recorded.
Seismic Bearing Capacity of Strip Footing on Excavations Considering Soil Strength Anisotropy Using Modified Pseudo‐Dynamic and Pseudo‐Static Approaches
Authors: Shirazizadeh Shabnam , Keshavarz Amin , Beygi Majid , Saberian Mohammad , Li Jie , Vali Ramin 
Published: October 2024

ABSTRACTAlthough considerable research has explored the static and seismic bearing capacity of strip footings on slopes or excavations, the influence of clay strength anisotropy on the bearing capacity of strip footing near excavations, specifically considering pseudo‐dynamic conditions, remains unexplored. This study used the finite element limit analysis (FELA) method to evaluate the impact of clay strength anisotropy on the seismic bearing capacity of strip footings. The effects of various dimensionless parameters on the bearing capacity were examined, which include shear wavelength, the setback distance ratio, vertical height ratio, soil strength ratio, soil strength heterogeneity, anisotropic ratio, and horizontal and vertical acceleration coefficients. Design charts were developed to compute the seismic bearing capacity of strip footings on nonhomogeneous and anisotropic excavations under pseudo‐static conditions. Furthermore, the effects of vertical acceleration coefficients and shear wavelength on the seismic bearing capacity of strip footing near excavation in nonhomogeneous and anisotropic soils were investigated.
A Real‐World Study on Adverse Reactions of Belimumab Based on the FDA Adverse Event Reporting System Database
Authors: Hai Le , Wu Jiaojiao , Xie Yingying 
Published: October 2024

ABSTRACTBackground and ObjectivesThis investigation leverages data derived from the United States Food and Drug Administration Adverse Event Reporting (FAERS) to real‐world adverse reactions associated with Belimumab, with the intention of providing guidance for safe clinical pharmacotherapy.MethodsData encompassing adverse drug event (ADE) reports relating to Belimumab from Q1 2011 to Q4 2023 within the FAERS were extracted and analyzed using methodologies such as the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi‐item Gamma Poisson Shrinker (MGPS).ResultsThe study identified a total of 19 825 ADE reports where Belimumab was the primary suspect medication, with the United States constituting the majority of reporting countries (16 312 cases, or 82.28%). Patients aged 18 to 64.9 years accounted for the largest demographic (36.29%), while the proportion of female patients (77.91%) significantly surpassed that of male patients (5.03%). The analysis uncovered 184 unique Preferred Terms (PTs) across 21 System Organ Classes (SOCs). Following selection through ROR, the SOC signal strength was prioritized as follows: Systemic disorders and administration site conditions, infections and infestations, a variety of musculoskeletal and connective tissue disorders, and conditions related to pregnancy, puerperium, and the perinatal period. The top five PTs for ADE reports not included in the product's labeling were hypersensitivity reactions, immunosuppression, non‐vascular diseases, herpes virus infections, and Sjögren's syndrome. The top five PTs for ADE signal strength not included in the labeling were disseminated cutaneous herpes zoster, herpes zoster meningitis, onycholysis, cyclothymic disorder, and mixed connective tissue disease.DiscussionBased on pharmacovigilance research utilizing the FAERS database, it is recommended that clinical monitoring of Bevacizumab should be intensified to support effective pharmaceutical care and ensure rational clinical medication use.
Preparation, characterization, and antibacterial evaluation of novel biodegradable self‐healing film based on fish collagen cross‐linked carboxymethyl cellulose
Authors: Zallaghi Mahsa , Esmkhani Maryam , Mirzaei Akbar , Javanshir Shahrzad 
Published: October 2024

AbstractBiodegradable films are widely explored to reduce environmental pollution. One of the best alternatives to reduce packaging waste is using biodegradable polymers. Fish collagen is gaining interest for its high biocompatibility and lack of religious or social restrictions compared with terrestrial collagen sources. This study aimed to prepare and characterize a biodegradable, antibacterial fish collagen‐based film (isinglass) cross‐linked with carboxymethyl cellulose, showcasing good mechanical performance, moisture barrier properties, and self‐healing capabilities. The films were prepared by mixing a solution of isinglass (IG) with different carboxymethyl cellulose (CMC) contents (0.1, 0.25, and 0.4 g) using triethanolamine (TEA) as a plasticizer. Up to the results, the optimized film contained 0.4 g CMC and 0.5 mL TEA. Morphological characteristics were investigated using scanning electron microscopy (SEM) and the interactions between the functional groups were analyzed using FT‐IR. The optimized CMC‐IG film possessed a tensile stress of around 1.02–3.32 MPa and an elongation at a break of 176%–241%. Moreover, the films showed a good self‐healing property and antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria. The good mechanical properties, antibacterial activity, self‐healing, and good moisture barrier made this thin film a good choice for food packaging applications.Highlights
Biodegradable film was made from fish collagen and carboxymethyl cellulose.
The film shows tensile stress of 1.02–3.32 MPa; elongation at break: 176%–241%.
The thin film exhibits self‐healing, flexibility, and an effective moisture barrier.
Excellent mechanical properties and antibacterial activity suitable for food packaging.