bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the influence of terroir on douro white and red wines characteristics: a study of human perception and electronic analysis
Authors: Marques Catarina , Dinis Lia-Tânia , Modesti Margherita , Bellincontro Andrea , Correia Elisete , Vilela Alice 
Published: September 2024

AbstractThe main objective of the present study was to evaluate terroir's role in white and red wine characteristics through human perceptions and electronic assessment. Douro wines, originating from the Douro Demarcated Region (DDR) in the North of Portugal, are renowned for their distinct terroir and historical significance. This study investigates twenty-one Douro wine samples (ten white, eleven red) from Baixo Corgo and Douro Superior through Fourier Transform Infrared (FTIR) spectroscopy, Electronic Nose (E-nose) analysis, and Quantitative Descriptive Analysis (QDA). The research has uncovered unique profiles for each sub-region, influenced by factors such as pH, alcohol content, and acidity. Through principal component analysis, the electronic nose analysis identifies separate clusters in red wines and highlights notable aromatic differences in white wines. The sensory analysis via quantitative descriptive analysis provides detailed wine profiles, emphasizing attributes such as persistence, sweetness, and acidity. Furthermore, emotional responses during wine tasting were assessed using FaceReader analysis, which revealed a range of emotions like happiness, sadness, surprise, fear, and disgust, with different intensities over time. These findings provide valuable insights for consumers, producers, and the enogastronomic industry.
Graphical abstract
Evaluating the hypoxic tolerance of two maturity stages of Antarctic krill (Euphausia superba) at its range edge
Authors: Tremblay Nelly , Cascella Kévin , Toullec Jean-Yves , Held Christoph , Fielding Sophie , Tarling Geraint A. , Abele Doris 
Published: September 2024

AbstractThe South Georgia region of the Southern Ocean represents the northernmost range edge for Antarctic krill. Of concern is the extent to which rapid warming of surface water temperatures and reduced oxygen contents around this region might challenge the physiological tolerance of krill, particularly the later maturity stages. Hypoxia is generally considered to be less than 30 to 20% of air saturation, hereafter as threshold hypoxia, while less than 10% of air saturation would qualify as severe hypoxia. These levels are unlikely to occur in the Southern Ocean but might happen in the middle of dense krill swarms. We investigated gene expression and biochemical markers related to aerobic metabolism, antioxidant defence, and heat-shock response under 6-h threshold (4 kPa; TH) and 1-h severe (0.6 kPa; SH) hypoxia exposure, to understand how hypoxia might alter respiratory and biochemical pathways in adult and subadult krill. After 6-h TH, subadults induced expression of citrate synthase (CS), and mitochondrial superoxide dismutase (also after 1-h SH) over normoxic expression levels. The maturity stages responded differently in glutathione peroxidase (1-h SH; lower in subadults and higher in adults), and CS (6-h TH; higher in subadults and lower in adults) activities as for the oxidative damage marker to lipids (6-h TH; lower in subadults and higher in adults). Subadults had a greater capacity than adults to deal with hypoxic conditions. This may be a strategy allowing them to exist in larger swarms to reduce predation pressure before reaching reproductive condition.
Dietary inflammatory index is not associated with bone mineral density in functionally able community-dwelling older adults
Authors: Linton Corey , Schaumberg Mia A. , Wright Hattie H. 
Published: September 2024

Abstract
Background
Osteoporosis poses a significant health and quality-of-life burden on older adults, particularly with associated fractures after a fall. A notable increase in pro-inflammatory cytokines associated with aging contributes to a decline in bone mineral density (BMD). Certain food components have been shown to influence an individual’s inflammatory state and may contribute to optimal bone health as a modifiable risk factor, particularly later in life. This study aims to explore the relationship between the dietary inflammatory index (DII) and dietary intake with BMD in community-dwelling older adults.

Methods
Heathy community-dwelling older adults aged 65–85 years. DII scores were calculated using 24-h dietary recalls, and lumbar spine (L1–L4) and femoral neck (ward’s triangle) BMD was assessed via dual-energy x-ray absorptiometry.

Results
A total of 94 participants were recruited (72.9 ± 4.9 years, 76.6% female) with 61.7% identified having an anti-inflammatory diet (average DII = − 0.50 ± 1.6), 88.3% were physically active, 47.8% were osteopenic and 27.7% osteoporotic. There was no significant difference between DII scores, nutrient or food group intake in groups stratified by BMD T-Score except for lean meats and alternatives food group (p = 0.027). Multiple regression analysis found no associations between DII and lumbar spine (unadjusted model β = 0.020, p = 0.155) or femoral neck BMD (unadjusted model β = − 0.001, p = 0.866).

Conclusion
Most of this cohort of functionally able community-dwelling older adults followed an anti-inflammatory diet. DII and dietary intake were not associated with BMD. This research underlines the complex interplay between modifiable and non-modifiable risk factors on the BMD of older, physically active adults.
Be bold, start cold! cold formalin fixation of colorectal cancer specimens granted superior DNA and RNA quality for downstream molecular analysis
Authors: Nano Ennio , Gambella Alessandro , Paudice Michele , Garuti Anna , Pigozzi Simona , Valle Luca , Grillo Federica , Mastracci Luca 
Published: September 2024

AbstractThe use of cold formalin fixation (CFF; i.e., fixating tissue samples with 4 °C precooled formalin) recently attracted further attention owing to its putative improved ability to preserve nucleic acid compared with standard room temperature formalin (SFF). In this study, we aimed to assess the effect of four formalin-based fixation protocols (SFF, CFF, delayed formalin fixation-DFF, and cold formalin hyperfixation; CFH) on both DNA and RNA quality. We collected 97 colorectal cancer (CRC) and analyzed 23 metrics of nucleic acid quantity and quality yield using a multiplatform approach by combining spectrophotometric, fluorimetric, electrophoretic, and polymerase chain reaction (PCR) assays. Following confirmation of fixation-protocol-related different effects via clustering analysis, CFF presented best metrics compared with all protocols, specifically positive coefficients of DV1000-60000, DV2/DV1, DNA λ ratio 260/230, and ABL gene expression absolute copies, and negative coefficient of DV150-1000. The SFF subgroup presented a positive coefficient of DV150-1000 and negative coefficients for DV1000-60000, DV2/DV1, RNA λ ratio 260/230, RNA QuBit concentration, DV100/200, RNA electrophoresis concentration and absolute quantity, and ABL copies. Overall, we confirmed the superior yield performances of CFF preservation for both DNA and RNA compared with the other protocols in our series of CRC samples. Pending further validations and clarification of the specific mechanisms behind these findings, our study supports the implementation of CFF in the pathology unit routine specimen management for tumor tissue molecular profiling.
Differences in the ventilatory thresholds in treadmill according to training status in 971 males and 301 females: a cross-sectional study
Authors: Benítez-Muñoz José Antonio , Benito Pedro J. , Guisado-Cuadrado Isabel , Cupeiro Rocío , Peinado Ana Belén 
Published: September 2024

Abstract

Purpose
To analyze the influence of training status on the percentage of maximum oxygen consumption, heart rate and velocity (%VO2max, %HRmax and %Vmax) at which ventilatory threshold 1 and ventilatory threshold 2 occur (VT1 and VT2, respectively), in males and females separately considering age, during a ramp incremental treadmill test.

Methods
791 males (36.8 ± 9.9 years) and 301 females (33.9 ± 11.0 years) performed a ramp incremental exercise test until fatigue where VT1 and VT2 were determined. Participants were classified as low, medium or high training status combining the oxygen consumption at VT1, VT2 and VO2max by clustering analysis.

Results
VO2max is poorly correlated with the %VO2max, %HRmax and %Vmax at which VT1 and VT2 occur (r < 0.3), in contrast, there is a positive correlation between oxygen consumption at VT1 and VT2 with the %VO2max, %HRmax and %Vmax at which VT1 and VT2, respectively, occur in males and females (r = 0.203–0.615). Furthermore, we observed the %VO2max, %HRmax and %Vmax at which thresholds occur were greater the higher the training status (all p < 0.003).

Conclusion
The physiological determinants of the percentage of maximum at which VT1 and VT2 occur are more related to oxygen consumption at VT1 and VT2, respectively, than to VO2max. Moreover, due to the higher percentage of maximum at which VT1 and VT2 occur in individuals with a higher training status, the common strategy consisting of establishing exercise intensity as a fixed percentage of maximum might not be effective to match intensity across individuals with different training status.

Clinical trial registration
NCT06246760.
Assessing wood grain and twist in a 2-year-old Eucalyptus bosistoana breeding population
Authors: Sharma Monika , Dijkstra Stephanie M. , Garrill Ashley , Collings David A. , Altaner Clemens M. 
Published: September 2024

Abstract
Key message
Radial grain patterns in young E. bosistoana trees are not random but are under genetic control and are correlated to other properties. Detailed high-resolution grain assessments match results from economical larger resolution techniques.

Abstract
Interlocked grain affects stem properties and timber value. Eucalyptus bosistoana is an emerging plantation species that is supported by a breeding programme, and which shows prominent interlocked grain. Grain assessments are difficult, either restricted in their spatial resolution or resource demanding. Comparative analysis of flexible and high-resolution X-ray microtomography grain measurements were shown to match the economical splitting test. Splitting demonstrated that, on average, grain in the 2-year-old E. bosistoana trees was straight close to the pith becoming slightly left-handed over the first 4 mm, but then developing a strong right-handed twist reaching an average of almost 5° by 12 mm. There was, however, a large degree of variability. Further, grain measures obtained from splitting tests correlated to the observed twisting of the stems. Lastly, twisting of timber was under genetic control. The combination of a heritability (h2) value of 0.34 and a coefficient of genetic variation value (rg) of 44% means that our assessment techniques for young trees could be incorporated into a breeding programme.
Bayesian dynamic models to estimate the impact of halting vehicle fleets on the air quality: a case study from Medellín, Colombia
Authors: Cardona-Jiménez Johnatan , Aguirre Carlos Andrés Pérez , Gomez-Miranda I. N. , Ramírez Isabel 
Published: September 2024

AbstractAccording to the World Health Organization (WHO, Ambient (outdoor) air pollution (who), 2020), outdoor air pollution is estimated to have caused 4.2 million premature deaths worldwide in 2019. Under this scenario, the development of statistical tools for assessing the impact of a possible reduction of fossil fuels-based transportation systems on air quality is more relevant than ever. This type of instruments can help policy makers to take the right path to tackle the problem of air pollution in urban environments. Thus, this work proposes a method to evaluate the impact of the reduction of vehicle fleets on air quality. The method is based on the construction of counterfactual time series, which represent observed air pollutants under a treatment of interest. In this case, the treatment of interest are the vehicle fleets on the streets. The construction of the counterfactual time series is based on Bayesian dynamic linear models. Several impact assessment measures are implemented, taking advantage of the counterfactual and observed time series (the observed pollutant without the treatment). The flexibility of the Bayesian approach allows easy inference of the impact quantities via high posterior density intervals. Some simulation analyses show that the method works well under different impact scenarios, and one application regarding Medellin’s case in Colombia is presented. For the application, it is shown that the drastic reduction in vehicle fleets during the COVID-19 mobility restrictions led to a significant reduction in the presence of different pollutants ($$\hbox {PM}_{{10}}$$

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10

, $$\hbox {PM}_{2.5}$$

PM

2.5

, $$\hbox {NO}_{{2}}$$

NO
2

, $$\hbox {NO}_{{x}}$$

NO
x

)
The change in lumbar lordosis from the standing to the lateral position: implications for lateral interbody fusion
Authors: Mills Emily S. , Wang Jennifer C. , Richardson Mary K. , Chung Brian C. , Mayer Lucas W. , Gallo Matthew C. , Alluri Ram K. , Hah Raymond J. , Heckmann Nathanael D. 
Published: September 2024

Abstract

Purpose
The purpose of this cross-sectional, observational study was to establish the relationship between standing lumbar lordosis (LL) and lateral decubitus LL.

Methods
Forty-nine subjects, 24 male and 25 female, were prospectively enrolled. Patients with pre-existing spinopelvic pathology were excluded. Standing, relaxed-seated, and lateral decubitus lateral radiographs were obtained. Radiographic variables measured included LL and lordosis change at each lumbar level (e.g. L1-L2). The change in LL when going from a standing to a lateral decubitus position (ΔLL), the correlation between standing and sitting LL compared to lateral decubitus LL, and the correlation between ΔLL and standing pelvic incidence (PI), pelvic tilt (PT), PI-LL mismatch, pelvic femoral angle (PFA), and sacral slope (SS) were calculated.

Results
Subjects had an average age of 25.7 ± 2.3 years and body mass index of 24.1 ± 3.0 kg/m2. On average, 11.9°±8.2° (range − 7° to 29°) of LL was lost when transitioning from a standing to the lateral decubitus position. Lateral decubitus LL had a higher correlation with standing LL (R = 0.725, p < 0.001) than with relaxed-seated LL (R = 0.434, p < 0.001). Standing PT and PI-LL mismatch had moderately negative correlations with ΔLL (R=-0.58 and R=-0.59, respectively, both p < 0.05). Standing PI and standing PFA had a low negative correlation with ΔLL (R=-0.31 and R=-0.44, respectively, both p < 0.05) Standing SS and LL had no correlation with ΔLL.

Conclusions
Standing LL was strongly correlated to lateral decubitus LL, although subjects lost an average of 11.9° from the standing to the lateral decubitus position. This has important implications for fusion in the lateral position.
Neuroanatomical photogrammetric models using smartphones: a comparison of apps
Authors: Piazza Amedeo , Corvino Sergio , Ballesteros Daniel , Campeggi Alice , Agosti Edoardo , Serioli Simona , Corrivetti Francesco , Bortolotti Carlo , De Notaris Matteo 
Published: September 2024

Abstract

Objectives
A deep knowledge of the surgical anatomy of the target area is mandatory for a successful operative procedure. For this purpose, over the years, many teaching and learning methods have been described, from the most ancient cadaveric dissection to the most recent virtual reality, each with their respective pros and cons. Photogrammetry, an emergent technique, allows for the creation of three-dimensional (3D) models and reconstructions. Thanks to the spreading of photogrammetry nowadays it is possible to generate these models using professional software or even smartphone apps. This study aims to compare the neuroanatomical photogrammetric models generated by the two most utilized smartphone applications in this domain, Metascan and 3D-Scanner, through quantitative analysis.

Methods
Two human head specimens (four sides) were examined. Anatomical dissection was segmented into five stages to systematically expose well-defined structures. After each stage, a photogrammetric model was generated using two prominent smartphone applications. These models were then subjected to both quantitative and qualitative analysis, with a specific focus on comparing the mesh density as a measure of model resolution and accuracy. Appropriate consent was obtained for the publication of the cadaver's image.

Results
The quantitative analysis revealed that the models generated by Metascan app consistently demonstrated superior mesh density compared to those from 3D-Scanner, indicating a higher level of detail and potential for precise anatomical representation.

Conclusion
Enabling depth perception, capturing high-quality images, offering flexibility in viewpoints: photogrammetry provides researchers with unprecedented opportunities to explore and understand the intricate and magnificent structure of the brain. However, it is of paramount importance to develop and apply rigorous quality control systems to ensure data integrity and reliability of findings in neurological research. This study has demonstrated the superiority of Metascan in processing photogrammetric models for neuroanatomical studies.
Longitudinal associations between prenatal internalizing symptoms and mindfulness traits with postnatal bonding difficulties
Authors: Garon-Bissonnette Julia , Bean Christian A. L. , Cárdenas Emilia F. , Jackson Maya , Abitante George , Humphreys Kathryn L. , Kujawa Autumn 
Published: September 2024

Abstract
Purpose
Mothers’ reported connection, or bond, with their infants develops across the early postnatal period and is relevant to mother and offspring functioning. Little is known, however, about early predictors of bonding difficulties over time. The present study examined prenatal anxiety, depressive symptoms, and trait mindfulness and variation in bonding difficulties in mothers across the first two months postnatal.

Methods
Participants were 120 pregnant women (Mage=31.09 years, SD = 4.81; 80% White). Measures of anxiety, depression, and five facets of mindfulness were administered mid-pregnancy (approximately 20 weeks gestation) and bonding difficulties were assessed every two weeks from approximately 1 to 7 weeks postnatal.

Results
Using multilevel modeling to account for within-person repeated assessments, we found an inverted U-shaped pattern across time such that bonding difficulties initially worsened before improving around five weeks postnatal. Prenatal anxiety and depressive symptoms were longitudinally associated with greater bonding difficulties overall and were unrelated to the trajectory of change. The mindfulness facets of acting with awareness and being nonjudging of one’s own experience were longitudinally associated with less bonding difficulties overall, weaker initial increases in bonding difficulties, and earlier improvements.

Conclusions
Prenatal anxiety and depression may be risk factors for bonding difficulties that are persistent across the early postnatal period. In contrast, mindfulness tendencies before childbirth, specifically acting with awareness and being nonjudging towards oneself, may support early feelings of bonding over time.
Surface roughness measurement in the notch area for estimating dynamic component load bearing capacity
Authors: Becker Nils , Tunsch Paul , Ulrich Carsten , Schlecht Berthold 
Published: September 2024

AbstractThe surface of a part can have an essential influence on its dynamic load bearing capacity as grooves and scratches act as more or less significant imperfections or additional micro-notches, depending on the interpretation. In order to accurately predict the fatigue strength, detailed knowledge of the surface structure in critical areas is essential but cannot always be established due to geometric constraints. To overcome these restrictions, a method utilizing impressions and a laser scanning microscope to take surface topography measurements in critical notch areas is used in this work. It enables precise and reproducible measurements to be taken. The method is used to conduct surface roughness measurements on fatigue strength specimens made of four different materials. Several roughness influence factors are calculated based on the results and their influence on the result of a recalculation using a fatigue strength assessment is shown as example. The calculated fatigue limit is compared against experimental results. The comparison shows significant scatter in prediction accuracy and no optimal surface influence factor can be recommended so far. It has to be noted that only a small sample of specimens, which were not designed for researching surface roughness influence in particular, were available for this work. The effects of roughness in the notch may not be completely captured by the available roughness influence factors. Furthermore, issues arise in the correct implementation of stress concentration factor based roughness influence factors. Further research is required to provide a more comprehensive understanding of the effects of surface roughness on the fatigue limit.
Amending “A note on solving the fleet quickest routing problem on a grid graph”
Authors: Andreatta Giovanni , De Francesco Carla , De Giovanni Luigi 
Published: September 2024

AbstractA recent paper (Di Giacomo et al. Cent Eur J Oper Res 28:1069–1090, 2020) on the Fleet Quickest Routing Problem on Grid graphs (FQRP-G) claims that eight levels guarantee that a fleet of vehicles, simultaneously starting from the bottom level of the grid, can reach the top level by moving on Manhattan paths without ever stopping and without collisions, independently of the number of vehicles and columns of the grid and the configuration of vehicles’ origins and destinations. In this amending note, we will analyse the results in Di Giacomo et al. (Cent Eur J Oper Res 28:1069–1090, 2020) and show that the routing rule leading to this claim cannot be applied to all instances of FQRP-G, and that it can cause collisions. The analysis points out sufficient conditions under which the proposed rule draws proven collision-free routes for FQRP-G using no more than eight levels. Computational experiments demonstrate the relevance of the eight-levels bound and the functionality of the routing rule in practice, showing that it correctly solves the majority of instances up to one thousand vehicles. From a theoretical perspective, the claim that eight (or any constant number of) levels are sufficient to solve any instance of FQRP-G remains an open issue.