bluuebunny/crossref_metadata_2025_split huggingface dataset:
A stacking sequence optimization strategy for process‐induced deformation of multi‐layer thick asymmetric laminates
Authors: Jia Hongli , Zhu Yingdan , Yan Chun , Chen Gang , Liu Dong 
Published: September 2024

AbstractThe occurrence of process‐induced deformations of composites laminates is challenging for assembly accuracy and may lead to a service life reduction of parts. However, it can be obviously mitigated through different optimization strategies on the basis of the accurate curing process simulation. In this study, a stacking sequence optimization strategy is proposed and applied to multi‐layer thick asymmetric laminates. The shapes of deformed laminate plates are experimentally investigated in virtue of the three‐dimensional coordinate measuring machine. The thermo‐chemical–mechanical behaviors of plates are first verified through the comparisons of model predicted and experimental process‐induced deformations. Then the nonlinear control formula achieved through the regression model is proposed for the direct relationship between stacking sequences and process‐induced deformations. Finally, the required solutions are generated by solving the control formula. With the comparisons between the average deformations before and after optimizations, it is found that the magnitudes of deformations are significantly reduced, especially when the unoptimizated deformations are large.Highlights
The thermo‐chemical–mechanical behavior can be described in the curing process simulation model.
The deformed shapes of multi‐layer thick asymmetric laminate plates are measured by a three‐dimensional coordinate measuring machine.
The stacking sequence optimization strategy is implemented by introducing a nonlinear control formula.
Experimental investigation on low‐velocity impact performance of carbon fiber reinforced polyether ether ketone thermoplastic composite materials in room and elevated temperature
Authors: Yang Chen , Mao Chunjian , Zhang Chao 
Published: September 2024

AbstractCarbon fibers woven‐ply reinforced polyether ether ketone (C/PEEK) thermoplastic composites are widely used in aerospace and high‐tech industries because of their exceptional resistance to low‐velocity impact. In this paper, experimental investigation is carried out to determine the low‐velocity impact performance of C/PEEK laminates at room temperature (RT) and high temperature (90°C and 150°C) environments. Both macroscopic and microscopic analyses are applied to examine the influence of temperature on the mechanical response and damage mode of the material. The attention of this investigation is on impact parameters such as maximum contact force, energy absorption rate, indentation depth, and damage mode. The findings show significant changes in material stiffness, rate of energy absorption, and indentation depth with rising temperature. Temperature variations have a notable effect on the PEEK matrix plasticity, C/PEEK composite interlaminar properties, crack initiation and propagation, and damage mode at the overlaps of warp and weft fibers, resulting in a transition from brittle to ductile failure.Highlights
Experimental investigation is carried out to study the low‐velocity impact performance of C/PEEK.
The effects of impact energy and environmental temperature on the low‐velocity impact performance of C/PEEK are investigated.
The mechanism of how environmental temperature affects the damage mode of C/PEEK is investigated.
Effect of geometric configurations and curvature angle of corrugated sandwich structures on impact behavior
Authors: Bozkurt Ilyas 
Published: September 2024

AbstractThe aim of this study is to numerically investigate the low‐velocity impact behavior of carbon fiber reinforced orthogonal woven fabric composite sandwich structures with five different geometric configurations and four different curve angles. Low velocity impact simulations were performed in LS DYNA finite element program to investigate the effects of core configuration and curve angle on peak contact force, energy absorption efficiency and damage mode. A progressive damage analysis based on the combination of the Hashin damage criterion and the Cohesive Zone Model (CZM) with bilinear traction‐separation law was performed using the MAT‐54 (ENHANCED_COMPOSITE_DAMAGE) material model. Among the five different cores, Trapezoidal core has the highest peak force average of 2.9 kN while Triangular core sandwich structure has the lowest with 1.23 kN. Absorbed energy efficiency average was highest for rectangular core with 0.95 and lowest for sinusoidal core with 0.69. The specific absorbed energy value was highest for Triangular core with 0.312 J/g and lowest for Sinusoidal core with 0.178 J/g. The damage area on the structure increased with increasing curve angle. It was determined that the core structure and curve angle is an effective parameter on peak force and energy absorption efficiency.Highlights
Impact behavior of sandwich composite structures was examined.
The effects of core type and curve angles on peak force, energy absorption efficiency and specific absorption energy were investigated.
Specific absorption energy rates were compared with studies in the literature.
Enhancing the interlaminar property of carbon fiber/poly(aryl ether ketone) composites with water‐soluble polyimide oligomer sizing agent
Authors: Gao Dongting , Liu Gang , Dong Le , Zhang Jindong , Yao Jianan , Chen Chunhai 
Published: September 2024

AbstractNovel water‐soluble polymer‐based sizing agents for carbon fiber/poly(aryl ether ketone) composites (CF/PAEK) have gained attention. However, a challenge remains: the sized CF bundles lack flexibility, and the effect of this on the properties of the composite has not been discussed. Herein, a water‐soluble polyimide oligomer (OL) sizing agent was developed, and the sizing effect was comprehensively evaluated. The conventional molecular weight polyimide (HP) sizing agent was also assessed for comparison. Although the interfacial shear strength of the sized CF monofilaments is enhanced due to improved surface roughness and wettability, the effect of the OL sizing agent on the composite's interlaminar shear strength (ILSS) and tow's flexibility differed from that of the HP sizing agent. Compared with HP‐CF, the yarn spreading rate of OL‐CF tow is increased by about eight times, and the ILSS of OL‐CF/PAEK composites with 2 and 5 MPa molding pressure is increased by 69% and 222%, respectively. The HP sizing agent weakens the tow's flexibility and yarn spreading ability, which is not conducive to the resin penetration in the tow, resulting in lower ILSS. In contrast, the OL sizing agent considers the tow's flexibility and composite's interlaminar property, showing great application potential.Highlights
Two PI‐based sizing agents with diverse film‐forming capacities were prepared.
The ILSS of CF/PAEK with OL sizing agent was significantly improved.
HP sizing agent weakened the tow flexibility and interlaminar property.
The interaction of sizing layer—resin penetration—ILSS was proposed.
How does career calling influence teacher innovation? The chain mediation roles of organizational identification and work engagement
Authors: Xiang Bowen , Xin Mengjie , Fan Xiaodong , Xin Zhaoyang 
Published: September 2024

AbstractTeacher innovation is closely related to the improvement of basic education quality, and the cultivation of innovative talent for the nation. However, few studies have employed the causes of teacher innovation from the perspective of intrinsic motivation. To explore the factors and mechanisms affecting teacher innovation, we surveyed 421 middle school teachers to investigate the mediating roles of organizational identification and work engagement in the relationship between career calling and teacher innovation. The results indicate that career calling has a significantly positive impact on teacher innovation and that both organizational identification and work engagement mediate the effect of career calling on teacher innovation. Moreover, organizational identification and work engagement act as chain mediators in the relationship between career calling and teacher innovation. Therefore, to promote teacher innovation in middle school, it is important to emphasize the sense of calling, organizational identification, and work engagement. Practical implications for how to promote teacher innovation are also discussed.
Investigating genotype‐phenotype correlations in primary ciliary dyskinesia: a sibling cohort study
Authors: Hazan Guy , Aviram Micha , Levanon Eran , Golan‐Tripto Inbal , Goldbart Aviv , Gatt Dvir 
Published: September 2024

AbstractIntroductionPrimary Ciliary Dyskinesia (PCD) is a complex mostly autosomal recessive disorder characterized by dysfunction of primary motor cilia, leading to multisystemic manifestations, primarily affecting the rhino‐sinopulmonary system. Despite advancements in understanding its pathogenesis, genotype‐phenotype correlations are not fully elucidated. Utilizing sibling cohorts offers a promising approach to investigate these genotype‐phenotype correlations in PCD.Materials and MethodsThis retrospective cohort study, conducted from 2010 to 2023 at Soroka University Medical Center in Be'er‐Sheva, Israel, included patients with a confirmed diagnosis of PCD. Variables and outcomes compared include typical presenting symptoms, lung function, structural changes in chest tomography (CT), and anthropometric data.ResultsSeventeen sibling patients from eight families met the inclusion criteria. At the last follow‐up visit, the median age was 16 years. Genetic diagnosis revealed homozygous pathogenic variants including DNAH11, DNAAF3, DNAL1, and ZMYND10. Full concordance rates were observed for unexplained neonatal respiratory distress, chronic cough, and rhinosinusitis in patients with DNAH11 mutations. The family with the DNAAF3 mutation exhibited the lowest difference in Forced Expiratory Volume in 1 s (FEV1) Z‐scores (0.48), but the highest differences in Forced Vital Capacity (FVC) Z‐scores (3.39). High differences in FEV1 Z‐scores were identified in the family with the DNAL1 mutation (2.06), while the lowest differences in FVC Z‐scores (0.39) were observed in the same family.DiscussionHigh concordance rates for certain mutations in clinical features suggest potential genotype‐phenotype correlations, in contrast to weak concordance in lung function. Challenges remain in establishing direct correlations between genetic mutations and clinical outcomes.
Efficient use of mepolizumab in children: An analysis of the economically justifiable price in Colombia
Authors: Buendía Jefferson Antonio , Zuluaga Andres Felipe 
Published: September 2024

AbstractIntroductionAsthma imposes a crucial economic burden on health systems, especially with the incorporation of new drugs. Recently, mepolizumab has been approved to prevent exacerbations in patients with eosinophilic asthma. This study explores the economically justifiable price of mepolizumab for preventing exacerbations in children with severe asthma.Materials and MethodsA model was developed using the microsimulation to estimate the quality‐adjusted costs and life years of two interventions: mepolizumab versus not applying standard treatment without mepolizumab. This analysis was made during a time horizon of 50 years and from a third‐payer perspective.ResultsMepolizumab was cost‐effective using a WTP of U$ 19,992 per QALY, but not at a WTP of U$ 4828, U$ 5128 per QALY. The economically justifiable cost for mepolizumab in Colombia is between $33 and $350 per dose, for WTP of U$ 4828, and U$ 5128 respectively. At the current price of Mepolizumab, U$ 780 per dose, only using a WTP higher than U$ 10,300 per QALY mepolizumab will be the best alternative to no mepolizumab.ConclusionOur study shows that the economically justifiable cost for mepolizumab in Colombia is between $33 and $350 per dose, for WTP of 4828 and 5180 respectively. This result should encourage more studies in the region that optimize decision‐making processes when incorporating this drug into the health plans of each country.
Analyzing Mexico's Indigenous internal migration dynamics through network centrality measures, 1990–2020
Authors: Segovia Miguel Alejandro Flores , Urrutia José Eliud Silva 
Published: September 2024

AbstractThis study examines the internal migration patterns among Mexico's Indigenous population from 1990 to 2020. We begin by estimating the total interstate migration flows for Indigenous groups and employ an advanced interaction component model to identify migration flows that exceed expectations. This model allows us to detect significant deviations and patterns within the migration data. Additionally, we apply network analysis techniques to identify states that are central to these migration flows and categorize states into distinct communities based on their migration interactions. Our findings reveal that Indigenous migration exhibits higher‐than‐expected flows, particularly from the West Central and North regions of Mexico. By contrast, non‐Indigenous migration shows greater flows, predominantly in the southern and central states. Through network analysis, particularly the use of eigenvector centrality, we identify Nayarit and Durango as key hubs for Indigenous migration, whereas Estado de Mexico and Ciudad de Mexico emerge as central nodes in non‐Indigenous migration. Our study highlights the growing significance of Mexico's northern region, with Nuevo León playing a crucial role in Indigenous and non‐Indigenous migration flow networks. This study's findings contribute valuable insights regarding the spatial dynamics of internal migration and the evolving migration patterns of Indigenous populations in Mexico.
Ginsenosides modulate hypothalamic–pituitary–adrenal function by inhibiting FKBP51 on glucocorticoid receptor to ameliorate depression in mice exposed to chronic unpredictable mild stress
Authors: Li Hui , Ge Meng , Lu Bofan , Wang Wei , Fu Yujuan , Jiao Lili , Wu Wei 
Published: September 2024

AbstractDepression, which affects millions of individuals worldwide, is associated with glucocorticoid (GC) impairment, with the FKBP51 protein playing a pivotal role. Ginsenosides, extracted from the root of Panax ginseng C.A. Mey, have demonstrated the potential to mitigate depression associated with GC dysregulation. This study evaluated the therapeutic efficacy of ethanol extract of P. ginseng (PG) in treating depression and its underlying FKBP51‐linked mechanism. Using chronic unpredictable stress, a depression model was developed in Kunming mice to test the efficacy of PG by observing changes in behaviors and protein expression in depressed mice. The mechanism of action was investigated through transfection with HEK293T cells. Depressed mice treated with PG demonstrated notable improvements: the rate of weight loss was reduced, sucrose preference and open‐field activity were enhanced, and the rate of apoptosis in hippocampal cells was decreased. Additionally, the HPA axis function appeared to be restored. These physiological adjustments coincided with an increase in GR levels and a decrease in FKBP51 levels. Altogether, these results suggested that PG treatment effectively alleviates depressive symptoms in mice. PG also moderated FKBP51‐GR interaction, lessening FKBP51's restraint on GR nuclear entry. This modulation may enhance the sensitivity of the GR response, reinforcing the negative feedback regulation of the HPA axis and thereby reducing depressive symptoms in mice. These findings highlight the potential of PG as a promising curative treatment for depression, providing a basis for the development of innovative treatments targeting the FKBP51‐GR pathway.
Progress and Perspective of Seafloor Regolith‐Sampling Robots for Ocean Exploration
Authors: Liu Jiabin , Ye Minhui , Zhu Haifei , Guan Yisheng , Zhang Tao 
Published: September 2024

ABSTRACTSeafloor exploration has significantly enriched our understanding of the marine environment, climate change, and the evolution of Earth. Seafloor sampling tools are instrumental in acquiring regolith samples for various investigations, including geological surveys and resource exploration. Detailed analysis of collected samples can uncover further hidden mysteries of the ocean. Over the past few decades, numerous research institutions have dedicated efforts to developing efficient seafloor regolith‐sampling robots (SRSRs). This paper provides a comprehensive overview of the progress and perspectives on SRSRs. First, the paper introduces the particularities of seafloor regolith sampling, including operation characteristics and sampling requirements. Second, current SRSRs are classified into seven categories based on different sampling methods, and their general characteristics are summarized. Subsequently, representative seafloor drilling and sampling robots (SDSRs) from around the world are introduced, with a focus on comparing mainstream sampling methods. Furthermore, the challenges and constraints in seafloor sampling, encompassing terrestrial technology and the marine environment, are analyzed and discussed in depth. The critical technologies involved in transitioning SRSRs from conceptualization to prototype development are detailed. Finally, important development trends of SRSRs are presented, including recent short‐term development goals and future long‐term development goals.
Submerged rigid vegetation effects on flow hydrodynamics within the pool morphology
Authors: Nosrati Kourosh , Afzalimehr Hossein , Raeisifar Hamidreza , Nazari‐Sharabian Mohammad , Karakouzian Moses 
Published: September 2024

AbstractThis research is centered on a comprehensive investigation into the impact of turbulence on the movement and dispersion of materials within a three‐dimensional (3D) bedform, specifically when there is a continuous presence of rigid vegetation submerged in the flow. To achieve our research objectives, we conducted extensive velocity measurements within a channel featuring this submerged vegetation. The measurements were carried out using an Acoustic Doppler Velocimeter (ADV). Additionally, our study delved into the intricate structures and turbulent characteristics of the flow, considering the coexistence of submerged vegetation and a 3D gravel pool. This pool featured entrance and exit slopes measuring 3 and 2.5°, respectively. Our experimental setup took place in a straight flume, measuring 14 m in length, 0.9 m in width, and 0.6 m in depth. The flume was equipped with transparent side walls to facilitate observations. Furthermore, our investigation extended to the spatial variations in velocity and turbulence distributions. We analyzed various parameters including turbulence kinetic energy, integral turbulence lengths, dispersion coefficients, and advective transport. The results revealed that integral length scales offer key insights into turbulent eddy behavior. In the presence of vegetation and a 3D bedform, turbulent eddies undergo notable changes, flattening in the longitudinal direction and expanding in the transverse and vertical directions. Moreover, longitudinal advection is notably higher compared to flows without vegetation in a uniform flow or bare channel, especially for z/H > 0.2. This indicates that the presence of vegetation and a 3D bedform leads to an increase in turbulent kinetic energy (k values) that surpasses the reduction in the time‐averaged velocity component (“U”) in the U × k term, thereby enhancing longitudinal advection.
Benzaldehyde Synthesis by the Selective Oxidation of Cinnamaldehyde Catalyzed by Fe2O3‐modified SBA‐15
Authors: Luo Xuan , Ma Zhiyuan , Su Tongming , Xie Xinling , Qin Zuzeng , Ji Hongbing , Chen Jianhua 
Published: September 2024

AbstractSelective oxidation is one of the primary methods used to synthesize high‐value‐added oxygen‐containing organic compounds from alkenes. In particular, the selective oxidation of natural cinnamaldehyde has gained prominence as one of the main routes to produce natural benzaldehyde, which is in short supply in the global spice market. In this study, FeSBA catalysts were synthesized by supporting Fe2O3 onto the surface of spherical SBA‐15 using pore‐induced deposition for the selective oxidation of cinnamaldehyde to benzaldehyde. The Fe2O3 supporting increased the specific surface area of SBA‐15 by approximately eightfold and significantly improved the utilization efficiency of the reaction sites on Fe2O3. Additionally, the formation of Fe−O−Si bonds by Fe2O3 and SBA‐15 promoted the generation of weak‐acidic sites on the catalyst surface, significantly increasing the oxygen‐physisorption capacity of Fe2O3. Furthermore, quenching experiments confirmed the generation of significant amounts of O2− and singlet‐oxygen species on the FeSBA surface. Theoretical calculations confirmed that the physisorption and chemisorption of cinnamaldehyde and oxygen, respectively, on the FeSBA surface promoted the formation of a tetrameric intermediate. These results contribute significantly to research on the selective oxidation theory of α,β‐unsaturated aldehydes to aldehydes using oxygen and could guide future studies aimed at elucidating and improving the process.
Trifluoromethylated 2H‐Thiete, 2,3‐Dihydrothiophenes and 3,4‐Dihydro‐2H‐thiopyranes S,S‐Dioxides in [3+2]‐Cycloaddition Reactions with Diazo Compounds and Nitrilimines
Authors: Markitanov Yuriy M. , Siry Sergiy A. , Timoshenko Vadim M. , Mykhaylychenko Sergiy S. , Khyzhan Alexandr I. , Rusanov Eduard B. , Shishkina Svitlana V. , Shermolovich Yuriy G. 
Published: September 2024

Abstract[3+2]‐Cycloaddition reactions of 3‐trifluoromethyl‐2H‐thiete 1,1‐dioxide, 4(5)‐trifluoromethyl‐2,3‐dihydrothiophene 1,1‐dioxides and 5(6)‐trifluoromethyl‐3,4‐dihydro‐2H‐thiopyrane 1,1‐dioxides with diazomethane proceed with the formation of regioisomeric mixtures of corresponding dihydropyrazole‐fused cycloadducts. Reactions of 3‐trifluoromethyl‐2H‐thiete 1,1‐dioxide with ethyl diazoacetate and in situ generated 2,2,2‐trifluorodiazoethane lead to the regioselective formation of pyrazolino‐sultine derivatives via rearrangement of initially formed pyrazoline‐fused thietane 1,1‐dioxides. Treatment of 3‐trifluoromethyl‐2H‐thiete 1,1‐dioxide and 4‐trifluoromethyl‐2,3‐dihydro‐thiophene 1,1‐dioxide with in situ generated N‐phenyl nitrilimines gives rise to dihydropyrazole‐ thietane 1,1‐dioxides and tetrahydrothiophene 1,1‐dioxides, respectively, in a regioselective fashion.
Computational Screening of FDA‐Approved Hepatitis C Drugs for Inhibition of VEGFR2 in Liver Cancer
Authors: Roney Miah , Issahaku Abdul Rashid , Tufail Nasir , Wilhelm Anke , Aluwi Mohd Fadhlizil Fasihi Mohd 
Published: September 2024

AbstractLiver cancer (LC) is one of the most common tumours and the leading cause of cancer‐related death globally. Amidst the problems associated with existing treatments, such as hepatotoxicity, recurrence, drug resistance, and other adverse effects, researchers are under pressure to find alternatives. Towards a comprehensive rationalisation of the search for new anti‐LC drugs among approved ones, we employed an in‐silico approach to accelerate the selection of the most efficacious LC drugs. The FDA‐approved hepatitis C virus (HCV) drugs were docked with the LC protein using the AutoDock Vina software. Compared to the control compound, two FDA‐approved HCV drugs (DB09102 and DB09027) were selected based on their binding energies and interactions with the target protein, which showed comparable binding energies. Furthermore, these compounds were then subjected to molecular dynamic simulation, principle component analysis, and MMGBSA using the AMBER20 software, and the results showed stable complexes compared to the control complex. All things considered, this study will help the scientific community and society find a novel drug to treat LC.