bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the performance of deformable image registration between planning CT and CBCT images for the pelvic region: comparison between hybrid and intensity-based DIR
Authors: Takayama Yoshiki , Kadoya Noriyuki , Yamamoto Takaya , Ito Kengo , Chiba Mizuki , Fujiwara Kousei , Miyasaka Yuya , Dobashi Suguru , Sato Kiyokazu , Takeda Ken , Jingu Keiichi 
Published: January 2017

AbstractThis study aimed to evaluate the performance of the hybrid deformable image registration (DIR) method in comparison with intensity-based DIR for pelvic cone-beam computed tomography (CBCT) images, using intensity and anatomical information. Ten prostate cancer patients treated with intensity-modulated radiation therapy (IMRT) were studied. Nine or ten CBCT scans were performed for each patient. First, rigid registration was performed between the planning CT and all CBCT images using gold fiducial markers, and then DIR was performed. The Dice similarity coefficient (DSC) and center of mass (COM) displacement were used to evaluate the quantitative DIR accuracy. The average DSCs for intensity-based DIR for the prostate, rectum, bladder, and seminal vesicles were 0.84 ± 0.05, 0.75 ± 0.05, 0.69 ± 0.07 and 0.65 ± 0.11, respectively, whereas those values for hybrid DIR were 0.98 ± 0.00, 0.97 ± 0.01, 0.98 ± 0.00 and 0.94 ± 0.03, respectively (P &lt; 0.05). The average COM displacements for intensity-based DIR for the prostate, rectum, bladder, and seminal vesicles were 2.0 ± 1.5, 3.7 ± 1.4, 7.8 ± 2.2 and 3.6 ± 1.2 mm, whereas those values for hybrid DIR were 0.1 ± 0.0, 0.3 ± 0.2, 0.2 ± 0.1 and 0.6 ± 0.6 mm, respectively (P &lt; 0.05). These results showed that the DSC for hybrid DIR had a higher DSC value and smaller COM displacement for all structures and all patients, compared with intensity-based DIR. Thus, the accumulative dose based on hybrid DIR might be trusted as a high-precision dose estimation method that takes into account organ movement during treatment radiotherapy.
Frequency-dependent response ofChromobacterium violaceumto sonic stimulation, and altered gene expression associated with enhanced violacein production at 300 Hz
Authors: Joshi Chinmayi , Patel Pooja , Singh Abhishek , Sukhadiya Jinal , Shah Vidhi , Kothari Vijay 
Published: January 2017

ABSTRACTChromobacterium violaceumwas subjected to sonic (100-2000 Hz) stimulation, and the effect on its cell yield and quorum sensing regulated pigment (violacein) production was investigated. Sound corresponding to the 300 Hz was found to promote (by 1.52 fold) violacein production the most, with only marginal impact on cell yield. Whole transcriptome analysis revealed that a total of 342 genes (i.e. 4.63% of whole genome) were significantly up-regulated in the sonic stimulated culture. Enhanced violacein production in the sound stimulated culture seems to have stemmed from enhanced expression of the genes involved in glucose metabolism through pentose phosphate pathway, resulting in increased availability of erythrose-4-phosphate, to be used for synthesis of tryptophan, the precursor for violacein synthesis. Multiple ribosomal subunit genes, enzyme coding genes, and those associated with secretion/transport were up-regulated owing to sonic stimulation. This study is a good demonstration of the ability of sound waves to alter bacterial metabolism.
Genome-wide mutational diversity inEscherichia colipopulation evolving in prolonged stationary-phase
Authors: Chib Savita , Ali Farhan , Seshasayee Aswin Sai Narain 
Published: January 2017

AbstractProlonged stationary-phase is an approximation of natural environments presenting a range of stresses. Survival in prolonged stationary-phase requires alternative metabolic pathways for survival. This study describes the repertoire of mutations accumulating in starvingE. colipopulations in lysogeny broth. A wide range of mutations accumulate over the course of one month in stationary-phase. SNPs constitute 64% of all mutations. A majority of these mutations are non-synonymous and are located at conserved loci. There is an increase in genetic diversity in the evolving populations over time. Computer simulations of evolution in stationary phase suggest that the maximum frequency obtained by mutations in our experimental populations can not be explained by neutral drift. Moreover there is frequent genetic parallelism across populations suggesting that these mutations are under positive selection. Finally functional analysis of mutations suggests that regulatory mutations are frequent targets of selection.
Explaining the demise of the intellectual capital statement in Denmark
Authors: Nielsen Christian , Roslender Robin , Schaper Stefan 
Published: January 2017

PurposeThe purpose of this paper is to provide an overview of the Danish Guideline Project (DGP) and its subsequent fate within participating companies since its conclusion in late 2002. Particular focus is placed on the traction that the intellectual capital statement (ICS) approach to reporting, as the principal outcome of the project, was able to acquire in practice.Design/methodology/approachFollowing the reconstruction of the original sample of 102 companies that originally participated in the project, a survey using semi-structured interviews was pursued among 64 individuals who were identified as having some involvement with the guideline project and/or producing ICSs in these companies. In addition to the interviews, a range of secondary information has been used to supplement the primary data and research protocol.FindingsThe project was found to have enjoyed only modest success and thereby failed to achieve any substantial traction among the participating companies and related public stakeholders. On balance, however, respondents believed that the exercise had been a positive experience, with benefits for the internal management of the companies, as well as for human capital (employees). The obstacles that radical initiatives such as the ICS continue to face should not be underestimated.Research limitations/implicationsA single study of a specific initiative necessarily entails many limitations. It is conceivable that the views of some of the participants in the guideline project who are absent from the present sample may provide details of a different experience, although it is unlikely that these would seriously challenge the findings reported here.Originality/valueThis study is the first to explore the fate of the critically acclaimed ICS approach among companies participating in the DGP.
Political skill, entrepreneurial orientation and organizational justice
Authors: Cong Cheng , Dempsey Michael , Xie Hong Ming 
Published: January 2017

PurposeThe purpose of this paper is to contribute to a unified theory of entrepreneurial orientation. To this end, the study considers the nexus of entrepreneurial orientation and venture performance contingent on entrepreneurial political skill, as well as in relation to organizational justice as it influences stakeholder commitment.Design/methodology/approachA diverse sample of 237 entrepreneurs from private entrepreneurial enterprises throughout an eastern province (Zhejiang) of China participated in a questionnaire study during three years. The study applies structural equation modeling and hierarchical moderated regression analyses to test the hypotheses.FindingsIn the context of a developing economy (China), the study verifies the influence of entrepreneurial political skill on entrepreneurial performance. Amongst those involved in the venture, a sense of organizational justice combined with entrepreneurial orientation work to moderate the entrepreneur’s political skill in achieving outcomes.Research limitations/implicationsLimitations of the study are the questionnaire survey identifies entrepreneurial “perceptions” of success or failure with actual success or failure; and responses are weighted to founders and top managers as representing entrepreneurial actors more generally.Practical implicationsThe study concludes that access to scarce resources and maintenance of goal congruence are more likely to be achieved when entrepreneurial innovativeness and pro-activeness are combined with entrepreneurial political skill in a setting of organizational justice.Social implicationsThe study finds that entrepreneurs are able to improve performance by instilling a group culture of trust and social justice.Originality/valueThe study is located contextually in the guanxi-centered social exchange atmosphere of China as the economy transforms from a planned to a market model, with institutional arrangements of a mixed economy of state-owned and privately owned enterprises. In this context, the study explores the constructs of entrepreneurial orientation in relation to entrepreneurial political skill in a context of organizational justice as they combine to influence a venture’s success.
Developing problem-solving skills in mathematics: a lesson study
Authors: Bradshaw Zoe , Hazell Amanda 
Published: January 2017

Purpose
Problem solving is a skill in mathematics which although always relevant has heightened priority due to the changes in the new mathematics GCSE (Department for Education, 2013). It has previously been a skill which is deemed underdeveloped within mathematics and therefore is a theme which teachers are seeking to improve and nurture in order to align with the new changes. The GCSE is the formal qualification that students take at the end of Key Stage 4 (KS4) in the UK. The paper aims to discuss these issues.

Design/methodology/approach
The focus of the enquiry was to explore, using lesson studies, the differences in students’ approaches to problem solving. Consequently, key themes relating to the mediation of gender, ability, and academic motivation surfaced. Considering these themes, the paper subsequently reflects upon pedagogical practices which might effectively develop students’ ability to problem solve. The study took part in a mixed gender comprehensive secondary school with students taking part in the observation lesson ranging in age from 11 to 12 years old. The authors are the teachers who took part in the lesson study. The teachers implemented observation techniques in the form of video and peer observation with the accompanying teacher. In addition, students provided feedback on how they approached the problem-solving tasks through a form of semi-structured interviews, conducted via the use of video diaries where no teachers were present to prevent power bias. Following this, a thematic analysis of both the observations and student video diaries generated conclusions regarding how said key themes shaped the students’ approaches to problem solving.

Findings
Students’ frustration and competitive need to find a specific answer inhibited their ability to thoroughly explore the problem posed thus overseeing vital aspects needed to solve the problem set. Many students expressed a passion for problem solving due to its freedom and un-rigid nature, which is something teachers should nurture.

Originality/value
Generally, teachers are led by a culture in which attainment is the key. However, an atmosphere should be developed where the answer is not the key and students can explore the vibrant diversity mathematics and problem solving can offer.
Greening transportation and parking at University of Coimbra
Authors: Cruz Luís , Barata Eduardo , Ferreira João-Pedro , Freire Fausto 
Published: January 2017

Purpose
This paper aims to explore the potential contribution of integrated traffic and parking management strategies to ensure more rational use of available parking spaces and to reduce fuel consumption and greenhouse gas emissions by commuters traveling to the University of Coimbra (UC) main campus.

Design/methodology/approach
An integrated modelling approach is used, including the characterization of supply and demand for parking and public transport, the creation and implementation of a survey to campus users and a life-cycle approach to assess six transportation and parking strategy scenarios.

Findings
This comprehensive analysis demonstrates the importance of integrated management measures to greening commuters’ transportation and parking within a University campus, identifying and quantifying opportunities for successfully making the transitions toward a more sustainable future, namely, increasing well-being and reducing environmental impact.

Practical implications
Results demonstrate that effective control of illegal parking and different forms of modal shift toward public transportation may contribute to important reductions in environmental impacts.

Social implications
Local population reveals willingness to participate in collective efforts to tackle traffic and parking problems, challenging authorities to take action and empowering ever more people to engage in such cathartic changes.

Originality/value
This comprehensive approach is highly valuable for the management of parking and traffic within the UC campus, providing innovative lessons on the social and environmental impacts that would result from this policy approach to urban areas (e.g. historical centers) facing the typical problems of a carbon society, such as traffic congestion, non-regulated parking and intensive car use.
Fighting elephants, suffering grass: oil exploitation in Nigeria
Authors: Umejesi Ikechukwu , Thompson Michael 
Published: January 2017

Purpose– The purpose of this paper is to understand the interactions of the different actors – the state, multinational oil and gas companies, environmental advocacy groups and local people – in the oil-rich Niger Delta.Design/methodology/approach– The paper draws on interviews, observations and focus group discussions, as well as on archival materials relating to the development of the oil and gas industry during the colonial period (i.e. pre-1960 Nigeria).Findings– A cultural theory-based analysis of the environmental risk perceptions of the different actors reveals a profoundly unconstructive institutional configuration, in which the collusion of two “solidarities – the oil companies (individualism) and the state (hierarchy) – has led to the exclusion of the local communities (egalitarianism) who have found themselves impoverished and marginalised (fatalism). With these two “elephants” – individualism/hierarchy and egalitarianism/fatalism – pitted against each other, it has been the “grass” – the natural environment that has suffered.Practical implications– Giving the local communities a stake in the wealth-creating process, from which they are at present excluded, would shift the pattern of inter-solidarity engagement from one in which two “active” (i.e. non-fatalist) voices silence the third to one in which each voice is able to make itself heard and is then responsive to the others.Originality/value– Innovative and current on under-researched topic and geography. The main fieldwork was conducted between 2007 and 2008, with further field visits and updates between 2009 and 2013.
Informal economic relations and organizations
Authors: Altman Yochanan , Morrison Claudio 
Published: January 2017

Purpose– The purpose of this paper is to identify the role of informal economic relations (IER) in the day-to-day working of organizations, thereby opening a way to theorizing and informed practice. The authors will present and discuss about the manifestation of informality in “everyday” reality of Soviet and transformation economies. Informed by Cultural theory and in particular the work of Gerald Mars, the authors are taking account ontologically and methodologically of Labour process theory.Design/methodology/approach– Through presentation of ethnographic data of detailed accounts and case vignettes in production and retail in the Soviet period of the late 1970s and 1980s and from the construction sector in contemporary Russia, with a focus on the labour process, the authors inform and discuss key processes in the informal working of organizations.Findings– In the Soviet system the informal economy co-existed in symbiosis with the formal command economy, implicitly adopting a “live and let live” attitude. In addition, informal relations were essential to the working of work organizations, sustaining workers’ “negative control” and bargaining power. contemporary Russian capitalism, while embracing informal economic activities, a legacy of the Soviet period, advocates an “each to his own” approach which retains the flexibility but not the bargaining space for employees. That facilitates exploitation, particularly of the most vulnerable workers, with dire consequences for the work process.Research limitations/implications– The paper provides a platform for theorizing about the role and place of IER in organizations. Of importance to managerial practice, the paper informs on those aspects of the work routine that remain hidden from view and are often excluded from academic discourse. The social implications are profound, shedding light on central issues such as recruitment, income distribution, health and safety and deregulated forms of employment.Originality/value– The paper examines economic behaviour under different economic-political regimes demonstrating continuities and changes during a fundamental social-economic reorientation of an important regional economy, through close observation at the micro and meso-level of, respectively, the workplace, organizations and industry, outlining theoretical, practical and social implications.
Nursing under inconsistent organizational conditions
Authors: Visser Max , van der Heijden Beatrice I.J.M. 
Published: January 2017

Purpose– Health care organizations often experience difficulty in aligning competing and changing demands, tasks and other organizational conditions in a consistent way, so that they uniformly influence employee outcomes in desired directions. The purpose of this paper is to theorize about the ways in which inconsistent organizational conditions affect employee outcomes, the authors introduce the concept of double bind situation, and assess its impact on negative employee outcomes among nurses in Dutch health care organizations.Design/methodology/approach– A survey was held among 4,018 Dutch nurses as a part of the European NEXT study. Various psychometric scales served as “proxy” operationalizations of the characteristics of the double bind situation and employee outcomes.Findings– Three of the seven distinguished characteristics of the double bind situation showed the expected direction and strength of impact. Together, they accounted for 20 percent explained variance in employee outcomes. The results suggest that a double bind situation does exist for the nurses surveyed and that three of its seven characteristics have an impact on negative employee outcomes.Originality/value– This study is among the first to empirically assess the impact of the double bind situation in health care organizations. In this way, it contributes valuable knowledge to the development and retention of staff in a relevant public sector, characterized by high personnel turnover and profound organizational change.
Preventing employee burnout during episodic organizational changes
Authors: Bellou Victoria , Chatzinikou Ioanna 
Published: January 2017

Purpose
– The purpose of this paper is to explore the effect that training and development have on employee burnout during episodic organizational changes. Moreover, it investigates the mediating role of overall job satisfaction (OJS) in conjunction with the moderating role of personal computer (PC) literacy.

Design/methodology/approach
– The study took place in Greece, in four branches of a public organization which adopted a new information technology (IT) system. Statistical analyses include exploratory and confirmatory factor analysis for instrument testing and multiple regressions for mediated moderation.

Findings
– The findings provide partial support to the hypotheses. It appears that employee training and development are significant predictors of burnout, indeed. However, OJS mediates the effect of one dimension of each, namely training effectiveness and support. Concerning PC literacy, a full-mediated moderation was revealed in the case of training effectiveness and a partial-mediated moderation in the case of support.

Research limitations/implications
– As with most studies examining change initiatives, the main limitations of this study are the cross-sectional design, the possible self-selection bias, and the limited sample size.

Practical implications
– The findings are important for preventing burnout during IT-related episodic changes, facilitating the successful implementation of change.

Originality/value
– To the best of knowledge, this study is the first to examine burnout in a changing public setting. Additionally, no previous direct evidence exists regarding the relationship between training and development and burnout while the evidence on the impact of organizational resources on burnout is scarce.
Epoetin beta pegol ameliorates flow‐mediated dilation with improving endothelial nitric oxide synthase coupling state in nonobese diabetic rats
Authors: Serizawa Kenichi , Yogo Kenji , Tashiro Yoshihito , Kawasaki Ryohei , Endo Koichi , Shimonaka Yasushi , Hirata Michinori 
Published: January 2017

SummaryBackground/AimsPatients with diabetic nephropathy have a high cardiovascular mortality. Epoetin beta pegol (continuous erythropoietin receptor activator, C.E.R.A.) is a drug for the treatment of renal anemia. In this study, we investigated the effect of C.E.R.A. on vascular endothelial function as evaluated by flow‐mediated dilation (FMD) and the relationship between hematopoiesis and FMD in diabetic nephropathy rats.MethodsMale Spontaneously Diabetic Torii rats (SDT, 22 weeks old) were used. C.E.R.A. (0.6, 1.2 μg/kg) was administered subcutaneously once every 2 weeks for 8 weeks. At 1 week after last administration (31 weeks old), we assessed FMD in the femoral arteries of anesthetized rats using a high‐resolution ultrasound system. FMD was also measured 1 week after single C.E.R.A. treatment (5.0 μg/kg) to examine the influence of hematopoiesis.ResultsFlow‐mediated dilation was significantly decreased in SDT rats before the start of C.E.R.A. treatment (22 weeks old). Repeated administration of C.E.R.A. dose‐dependently improved FMD in SDT rats (31 weeks old) without changing blood glucose, nitroglycerin‐induced vasodilation, or kidney function. Long‐term administration of C.E.R.A. improved the state of endothelial nitric oxide synthase uncoupling in the femoral arteries of SDT rats, which showed a positive correlation with FMD. On the other hand, there was no correlation between FMD and Hb or Hct in SDT rats. Furthermore, at 1 week after single administration of C.E.R.A., FMD was not significantly improved although hemoglobin levels were comparable with levels following long‐term C.E.R.A. treatment.ConclusionLong‐term treatment with C.E.R.A. improved FMD in SDT rats even after onset of endothelial dysfunction.
South American terrestrial larva of Scirtidae (Coleoptera: Scirtoidea): the adaptation of Scirtidae larvae to saproxylic habitat is more common than expected
Authors: Ruta Rafał , Klausnitzer Bernhard , Prokin Alexandr 
Published: January 2017

AbstractTerrestrial larvae of Scirtidae were found in southern South America (Chile) for the first time. The morphology of the larvae is described in detail and compared with terrestrial larvae known from Borneo, New Zealand and Australia. Special attention is paid to the prothoracic sclerites, which were examined for the first time in the family and compared with selected genera of Scirtidae. Large presternal sclerites seem to be a typical feature of terrestrial larvae of Scirtidae. Chilean saproxylic larvae seem to be specialised detritus feeders, feeding in water trapped in wood cavities.