bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing Impairment and the Amelioration of Avoidable Medical Error: A Cross-Sectional Survey
Authors: Henn Patrick , O’Tuathaigh Colm , Keegan Darrelle , Smith Simon 
Published: February 2017

Objectives
Hearing loss contributes to suboptimal medical treatment. We investigated the nature and magnitude of potential health-care harm of hearing loss alone on a patient’s understanding of medical consultations, investigations, and treatments of health conditions unrelated to their hearing loss.

Methods
A cross-sectional, questionnaire-based design of a convenience sample of students with hearing loss, registered with the institutional disability support service in 8 Irish and 15 UK third-level institutions. Content analysis of open-ended item responses identified and coded emergent themes. Closed-ended questionnaire items recorded demographic and clinically relevant characteristics.

Results
Ninety-five responses were received and analyzed. Fifty-six (58.9%) indicated “yes” to mishearing a physician/nurse in a hospital. Approximately 60.7% identified this in relation to consultation content; 33.9% mishearing; and 21.4% misinterpreting what was said, including diagnosis, guidelines and advice, and matters relating to medications. Approximately 22.3% indicated physician/nurse-patient communication failures; 19.6% identified failure to initiate/maintain eye contact, turning away from the patient, speaking while wearing surgical masks, excluding the possibility of lip reading. Approximately 7.1% identified speaking in too low a volume or too fast. Concerning common words misheard or misinterpreted, 23.2% identified phonological similarity such as similar sounding words and numbers, 7.4% discrimination of unvoiced consonants. Similar findings emerged in GP clinics.

Conclusions
Most hearing-impaired students experienced difficulty in understanding health-care professionals in a hospital and general practice setting. This underscores the importance for health-care providers to identify hearing-impaired patients and to augment communication using visual aids, a quite environment and optimizing lip reading communication.
What is new in the management of skin and soft tissue infections in 2016?
Authors: Poulakou Garyphallia , Giannitsioti Efthymia , Tsiodras Sotirios 
Published: February 2017

Purpose of review
Skin and soft tissue infections (SSTIs) are the most frequent infectious cause of referrals to emergency departments and hospital admissions in developed world, contributing to significant morbidity and healthcare expenditures. We sought to review recent literature covering epidemiology and management of SSTIs.

Recent findings
Incidence trends of SSTIs were increasing worldwide with Staphylococcus aureus and streptococci predominating and methicillin-resistant S. aureus (MRSA) posing additional challenges, because of high rates of treatment failure and relapse. Development of new antimicrobials was associated with an appraisal of regulatory definitions and endpoints. Prediction of clinical response can be very tricky, because of variable risk factors for recurrence or treatment failure, depending mostly on the host. Precise indications for new antimicrobials should be established; their integration into clinical practice algorithms may serve reduction of unnecessary admissions, overtreatment and total costs.

Summary
New antimicrobials with activity against MRSA have been recently launched. Long-acting agents, mainly oritavancin and dalbavancin, provide the opportunity of single-dose treatment and early discharge. Further outpatient treatment options include new per os antibiotics such as oxazolidinones. Validated assessment tools are urgently needed to support decision-making toward rational resource utilization and delivery of optimal treatment.
Use of Model-based Iterative Reconstruction to Improve Detection of Congenital Cardiovascular Anomalies in Infants Undergoing Free-breathing Computed Tomographic Angiography
Authors: Kligerman Seth , Bolster Ferdia , Mitchell Jason , Henry Travis , Jeudy Jean , White Charles S. 
Published: February 2017

Purpose:
The aim of the study was to assess the detection of congenital cardiovascular anomalies (congenital heart disease) in neonates and infants using model-based iterative reconstruction (MBIR) algorithm compared with hybrid iterative reconstruction (HIR) and filtered back projection (FBP) reconstructions on axial computed tomography (CT) performed at minimum scanner dose.

Materials and Methods:
Over 1 year, all CT angiographies performed in infants below 3 months of age with congenital heart disease were assessed retrospectively. All were scanned on a 256-slice CT (Brilliance iCT) using single axial rotation at minimum allowable scanner dose (80 kV/10 mAs), with patients free-breathing. Intravenous contrast was 1 mL/kg. Scan reconstruction was 0.9 mm/0.45 mm overlap, reconstructed with FBP, HIR (iDose5), and MBIR (IMR2). The 3 reconstructions per study were anonymized and randomized. Four cardiac radiologists (23, 9, 7, and 6 y experience) evaluated each reconstruction on a workstation for presence of an atrial septal defect, a ventricular septal defect, patent ductus arteriosus, and surgical shunt or anomalies of the aorta, pulmonary arteries, and pulmonary veins. Unevaluable structures were classified as nondiagnostic. Gold standard was surgery or both echocardiogram and cardiac catheterization. The sensitivity, specificity, and accuracy were determined for each reconstruction.

Results:
Fifteen scans in 14 infants met the inclusion criteria, with a total of 48 anomalies. Pooled sensitivity for MBIR of 0.82 (range, 0.75 to 0.9) was significantly better than those for FBP (0.58; range, 0.54 to 0.6; P<0.001) and HIR (0.67; range, 0.60 to 0.79; P<0.001). Pooled accuracy of MBIR, HIR, and FBP was 0.91, 0.84, and 0.81, respectively. Readers deemed 39 and 15 structures nondiagnostic with FBP and HIR, respectively, versus 2 with MBIR (MBIR-FBP, MBIR-HIR, P<0.0001). The CTDIvol, DLP, and estimated dose for all cases was 0.52 mGy, 4.2 mGy×cm, and 0.16 mSv.

Conclusions:
MBIR significantly improves the detection of congenital anomalies in neonates and infants undergoing CT angiography at minimum allowable dose.
mTORC1 controls phase-separation and the biophysical properties of the cytoplasm by tuning crowding
Authors: Delarue M. , Brittingham G.P. , Pfeffer S. , Surovtsev I.V. , Ping-lay S. , Kennedy K.J. , Schaffer M. , Gutierrez J.I. , Sang D. , Poterewicz G. , Chung J.K. , Plitzko J. , Groves J.T. , Jacobs-Wagner C. , Engel B.D. , Holt L.J. 
Published: February 2017

Summary (Abstract)Macromolecular crowding has a profound impact on reaction rates and the physical properties of the cell interior, but the mechanisms that regulate crowding are poorly understood. We developed Genetically Encoded Multimeric nanoparticles (GEMs) to dissect these mechanisms. GEMs are homomultimeric scaffolds fused to a fluorescent protein. GEMs self-assemble into bright, stable fluorescent particles of defined size and shape. By combining tracking of GEMs with genetic and pharmacological approaches, we discovered that the mTORC1 pathway can tune the effective diffusion coefficient of macromolecules ≥15 nm in diameter more than 2-fold without any discernable effect on the motion of molecules ≥5 nm. These mTORCI-dependent changes in crowding and rheology affect phase-separation bothin vitroandin vivo.Together, these results establish a role for mTORCI in controlling both the biophysical properties of the cytoplasm and the phase-separation of biopolymers.
The kinetics of pre-mRNA splicing in theDrosophilagenome: influence of gene architecture
Authors: Pai Athma A. , Henriques Telmo , McCue Kayla , Burkholder Adam , Adelman Karen , Burge Christopher B. 
Published: February 2017

AbstractProduction of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning (“intron definition”) or exon-spanning (“exon definition”) pairs. To understand how exon and intron length and splice site recognition mode impact splicing, we measured splicing rates genome-wide inDrosophila, using metabolic labeling/RNA sequencing and new mathematical models to estimate rates. We found that the modal intron length range of 60-70 nt represents a local maximum of splicing rates, but that much longer exon-defined introns are spliced even faster and more accurately. Surprisingly, we observed low variation in splicing rates across introns in the same gene, suggesting the presence of gene-level influences, and we identified multiple gene level variables associated with splicing rate. Together our data suggest that developmental and stress response genes may have preferentially evolved exon definition in order to enhance rates of splicing.
Spodoptera exigua caterpillar feeding induces rapid defense responses in maize leaves
Authors: Tzin Vered , Hojo Yuko , Strickler Susan R. , Bartsch Lee Julia , Archer Cairo M. , Ahern Kevin R. , Christensen Shawn A. , Galis Ivan , Mueller Lukas A. , Jander Georg 
Published: February 2017

ABSTRACTInsects such as beet armyworm caterpillars (Spodoptera exigua) cause extensive damage to maize (Zea mays) by consuming foliar tissue. Maize plants respond to such insect attack by triggering defense mechanisms that involve large changes in gene expression and the biosynthesis of specialized metabolites and defense signaling molecules. To investigate dynamic maize responses to herbivore feeding, leaves of maize inbred line B73 were infested with S. exigua caterpillars for 1 to 24 hours, followed by comprehensive transcriptomic and metabolomic characterization. Our results show that the most significant gene expression responses of maize to S. exigua feeding occur at early time points, within 4 to 6 hours after caterpillar infestation. However, both gene expression and metabolite profiles continued changing during the entire 24-hour experiment while photosynthesis genes were gradually decreased. The primary and specilaze metabolism shift maught be temporal and dynamic processes in the infested leaf tissue. We analyzed the effects of mutating genes in two major defense-related pathways, benzoxazinoids (Bx1 and Bx2) and jasmonic acid (Lox8), using Dissociation (Ds) transposon insertions in maize inbred line W22. Together, these results show that maize leaves shift to implementation of chemical defenses within one hour after the initiation of caterpillar attack. Thus, the induced biosynthesis of specialized metabolites can have major effects in maize-caterpillar interactions.HIGHLIGHTA comprehensive transcriptic and metabolomic profiling time course of maize foliar responses to caterpillar feeding identifies genes for the synthesis of benzoxazinoids and phytohormones.
Developmental Downregulation of LIS1 Expression Limits Axonal Extension and Allows Axon Pruning
Authors: Kumamoto Kanako , Iguchi Tokuichi , Uemura Takuya , Sato Makoto , Hirotsune Shinji 
Published: February 2017

AbstractThe robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits functional recovery following nerve damage. While external factors influencing axonal growth have been extensively investigated, relatively little is known about the intrinsic molecular changes underlying the age-dependent reduction in regeneration capacity. We report that developmental downregulation of LIS1 is responsible for the decreased axonal extension capacity of mature dorsal root ganglion (DRG) neurons. In contrast, exogenous LIS1 expression or endogenous LIS1 augmentation by calpain inhibition restored axonal extension capacity in mature DRG neurons and facilitated regeneration of the damaged sciatic nerve. The insulator protein CTCF suppressed LIS1 expression in mature DRG neurons, and this reduction resulted in excessive accumulation of phosphoactivated GSK-3β at the axon tip, causing failure of the axonal extension. Conversely, sustained LIS1 expression inhibited developmental axon pruning in the mammillary body. Thus, LIS1 regulation may coordinate the balance between axonal growth and pruning during maturation of neuronal circuits.Summary StatementDevelopmental downregulation of LIS1 coordinates the balance between axonalelongation and pruning, which is essential for proper neuronal circuit formation but limits nerve regeneration.
Translation efficiency is maintained at elevated temperature inE. coli
Authors: Morgan Gareth J , Burkhardt David H , Kelly Jeffery W , Powers Evan T 
Published: February 2017

ABSTRACTCellular protein levels are dictated by the balance between gene transcription, mRNA translation and protein degradation, among other factors. Cells must manage their proteomes during stress; one way in which they may do so, in principle, is by differential translation. We used ribosome profiling to directly monitor translation inE. coliat 30 °C and investigate how this changes after 10-20 minutes of heat shock at 42 °C. Translation is controlled by the interplay of several RNA hybridization processes, which are expected to be temperature sensitive. However, translation efficiencies are robustly maintained after thermal heat shock and after mimicking the heat shock response transcriptional program at 30 °C. Several gene-specific parameters correlated with translation efficiency, including predicted mRNA structure and whether a gene is cotranslationally translocated into the inner membrane. Genome-wide predictions of the temperature dependence of mRNA structure suggest that relatively few genes show a melting transition between 30 °C and 42 °C, consistent with our observations. A linear model with five parameters can predict 33% of the variation in translation efficiency between genes, which may be useful in interpreting transcriptome data.
Innovative tools and techniques to ensure effective employee engagement
Authors: Rao M.S. 
Published: February 2017

Purpose
The purpose of this paper is to offer innovative tools and techniques to ensure employee engagement.

Design/methodology/approach
The paper outlines the reasons for employee disengagement and enlightens the advantages of employee engagement for both employees and organizations. It unfolds several research findings on employee engagement and illustrates with the examples of global companies including Cummins, DHL Express, Southwest Airlines, Google, and Virgin.

Findings
It concludes that employee engagement is a two-way street.

Practical implications
The tools and techniques adopted by leaders can be applied in any industry and in any size of organization.

Social implications
The social implications of this research suggest that leaders can ensure employee engagement by following these innovative tools and techniques.

Originality/value
It implores both employers and employees to take ownership of their roles and responsibilities to achieve organizational excellence and effectiveness.
More than just a green building
Authors: Jones Louise , Wong Winky 
Published: February 2017

Purpose
The slogan “Go Green” has been embraced by a range of organizations including businesses and universities in recent decades. Within higher education academic libraries, as a key service unit in their parent institution, have an important role to play in supporting this mission. The authors have seen many academic libraries strive to “Go green” by designing a green library, whether a new build or renovation. The paper aims to discuss these issues.

Design/methodology/approach
This paper discusses how the Chinese University of Hong Kong (CUHK) Library formulates, develops and implements its green strategy and how the strategy has gradually reshaped its services. First, the authors consider how the concept of sustainability has affected services provided by academic libraries, and why green strategies are a practical and feasible approach. The authors then use CUHK Library as a case study, siting the development of its green strategies in the context of, the University’s approach to sustainability and the wider CUHK community, and ultimately the Library’s overall strategic plan. The third section describes how the library implements its green strategies in different areas, from the daily operation of library offices and services offered to users, to the planning of a library extension and broader sustainability initiatives. Issues of evaluation are discussed and the authors conclude the paper with future plans.

Findings
There are very few academic libraries in the USA that are Leadership in Energy and Environmental Design certified.

Originality/value
The authors argue that pursuing a green building may not be the strategic focus for many academic libraries. In taking a more holistic approach to sustainability through practical measures, academic libraries need to formulate and develop wider green strategies beyond a green building. “Go Green” impacts not only the attitudes towards the environment but also changes the way academic libraries serve their users and community.
Managed earnings
Authors: Meyer Heather M. , Ujah Nacasius U. 
Published: February 2017

PurposeThe decisions marketing managers make on advertising expenditures are vital to maintaining the sales and profitability of a firm. However, these decisions have not been taken into account to a great enough extent when determining a firm’s performance. The purpose of this paper is to better understand the marketing-finance interface and to reveal the effect marketers’ discretionary advertising expenditures can have on firm performance. In particular, the real activities method of managed earnings (ME) will be used to study this phenomenon.Design/methodology/approachThe initial sample consisted of all the companies that appear in the North American COMPUSTAT files over the period 1970-2014. Since the focus here is on the effect of discretionary advertising expenses on firm performance, the authors restricted the samples to only include observations with advertising expenses. Therefore, the sample included 14,732 firms.FindingsOLS regressions revealed a negative relationship between marketers’ discretionary advertising expenditures and firm performance using return on assets as a proxy for firm performance. Additional regressions displayed similar results for return on sale and return on cash adjusted asset proxies. Fixed effect and Tobit regressions also confirmed these findings. Finally, this effect was especially true for low performing firms. The economic significance of these findings on firm performance is also discussed.Originality/valueThe decisions made by marketing managers on advertising promotional efforts impact sales directly and brand equity indirectly, but they can also have an impact on firm performance. Therefore, it is important for investors to understand the level of ME in relation to marketing and advertising decisions that are taking place at their firm.
It’s my choice! Investigating barriers to pro-social blood donating behaviour
Authors: Pentecost Robin , Arli Denni , Thiele Sharyn 
Published: February 2017

PurposeThe purpose of this paper is to investigate barriers to pro-social behaviour in the form of blood donating using self-determination theory.Design/methodology/approachRespondents were recruited through intercepts at a major international university and at points within the community in a capital city in Australia. Sampling was conducted over a three-week period resulting in a sample of 617 respondents.FindingsResults show intrinsic motivations positively influence intentions towards blood donation, self-identity, and locus of control. Further, despite positively influencing other factors, external regulation positively influenced amotivation indicating the more likely people feel pressured to donate blood, the less likely they will be motivated to donate blood.Originality/valueThis would suggest one way to influence more people to become donors is to place greater focus on the positive emotional feelings they derive from the act of donating blood and the control they have over that donation. Using external regulation strategy which often suggests people “must” or “have-to” donate blood may be limiting blood donation numbers.
Responsible brands vs active brands? An examination of brand personality on brand awareness, brand trust, and brand loyalty
Authors: Molinillo Sebastian , Japutra Arnold , Nguyen Bang , Chen Cheng-Hao Steve 
Published: February 2017

Purpose
There is a rise in interest on the topic of consumer-brand relationships (CBRs) among practitioners and academics. Consumers are said to build relationships with brands that have a personality congruent with their own. The purpose of this paper is to investigate two types of brand personality traits, namely, responsible brands and active brands to predict prominent CBR constructs, including brand awareness, brand trust, and brand loyalty.

Design/methodology/approach
This study was based on an electronic survey of 339 respondents. Structural equation modeling was used to analyze the data.

Findings
The results show that brand personality positively affects the three CBR constructs. Specifically, the focus is shifted to the two major personality dimensions, responsible and active, respectively. The results indicate that an active brand is a stronger predictor of brand awareness compared to a responsible brand. However, a responsible brand is a stronger predictor of brand trust as well as brand loyalty compared to an active brand. Surprisingly, the results display that active brands lower brand trust and brand loyalty.

Practical implications
This finding informs brand managers that projecting active brand personality leads to higher awareness. However, projecting more responsible brand leads to greater trust and loyalty. The study highlights that having one personality may not be sufficient to develop an enduring CBR, but a brand personality must “evolve” and progress as the relationship develops over time. Such dynamic brand personality may provide a more long-lasting brand strategy and a greater source of competitive advantage.

Originality/value
The present study contributes to the marketing literature in three different ways. First, this study adds to the body of knowledge on the relationship between brand personality and CBR constructs using the new measure of BPS. Second, this study assesses the individual level of the new BPS, particularly responsibility and activity, on the three CBR constructs, and in doing so, the study responds to previous studies’ calls to assess the individual capacity of the brand personality dimensions to get consumer preference or loyalty. Third, the study displays which ones of the two dimensions in the new BPS (i.e. responsible and active) may be better predictors to the three CBR constructs.