bluuebunny/crossref_metadata_2025_split huggingface dataset:
Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during skeletal muscle regeneration
Authors: Lu Yue , Walji Tezin , Pandey Pratima , Zhou Chuanli , Habela Christa W. , Snapper Scott B. , Li Rong , Chen Elizabeth H. 
Published: October 2024

AbstractSkeletal muscle regeneration is a multistep process involving the activation, proliferation, differentiation, and fusion of muscle stem cells, known as satellite cells. The fusion ofsatellitecell-derived mononucleatedmuscle cells (SCMs) is indispensable for the generation of multinucleated, contractile myofibers during muscle repair. However, the molecular and cellular mechanisms underlying SCM fusion during muscle regeneration remain poorly understood. In this study, we uncovered an essential role for branched actin polymerization in SCM fusion. Using conditional knockouts of the Arp2/3 complex and its actin nucleation-promoting factors, N-WASP and WAVE, we demonstrated that branched actin polymerization is required for the SCM fusion, but not for satellite cell proliferation, differentiation, and migration. We showed that the N-WASP and WAVE complexes have partially redundant functions in regulating SCM fusion. Furthermore, we showed that branched actin polymerization is essential for generating invasive protrusions at the fusogenic synapses in SCMs. Taken together, our study has identified new components of the myoblast fusion machinery in skeletal muscle regeneration and demonstrated a critical role for branched actin-propelled invasive protrusions in this process.
Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria
Authors: Guo Qian-Jin , Hou Tingting , Xie Wen-Jun , Zhang Jing-Ruo , Ma Xin-Lei , Guo Yingna , Wang Xiao-Ting , Wang Li-Peng , Lu Ming-Ao , Wu Zhaofa , Wang Hong-Guang , Chen Yi-Hang , Li Yu-Long , Wang Shi-Qiang 
Published: October 2024

AbstractRecent structural analyses showed that the calcium homeostasis modulator-2 (CALHM2) forms a mega channel, but its cellular location and endogenous function are yet unknown. We found that native CALHM2 resides on the mitochondrial inner membrane and constitutes an ATP-regulated ATP release channel. CALHM2 knockdown/knockout decreases cytosolic ATP concentration, and thereby compromises energy-sensitive processes, such as intracellular Ca2+handling. However, CALHM2 loss-of-function elevates ATP concentration in the mitochondrial matrix, dephosphorylates key enzymes in the mammalian target of rapamycin (mTOR) pathway, and promotes longevity in CALHM2 knockout mice. These findings reveal that CALHM2 constitutes a novel regulator of mitochondrial metabolism, which may have important implications in aging and diseases.
BMP signaling modulations control primitive streak patterning
Authors: Simon Gaël , Plouhinec Jean-Louis , Gilardi-Hebenstreit Pascale , Sorre Benoit , Collignon Jérôme 
Published: October 2024

AbstractThe primitive streak (PS) is the embryonic structure from which mesoderm and definitive endoderm cells emerge to form organs and fetal tissues. The identities of the cells leaving the PS depend on both the time and the position at which they exit. Three signaling molecules, BMP4, WNT3 and NODAL, play key roles in determining these identities, but it has been difficult to disentangle the contribution of each to this process in the mouse embryo. Using 2D gastruloids that recapitulate early aspects of mouse gastrulationin vitro, we have previously shown that WNT3 and NODAL promote distal PS fates on their own, and proximal PS fates in the presence of BMP4. We now detail further the impact of BMP4 on the cell identities produced in gastruloids. Single cell RNA-seq analysis shows that prolonged exposure to BMP4 results in the presence of all the cell types, including primordial germ cells, which normally form from the most proximal part of the pluripotent epiblast. We then show that reducing the duration or intensity of gastruloid exposure to BMP4 can allow the emergence of more distal cell identities, such as paraxial mesoderm, alongside anterior PS derivatives. These results, which are consistent with embryological studies, provide key elements for understanding how the varied output of the PS is controlled.
Spin dynamics and possible topological magnons in the nonstoichiometric pyrochlore iridate
Tb2Ir2O7
studied by RIXS
Authors: Faure Q. , Toschi A. , Soh J. R. , Lhotel E. , Detlefs B. , Prabhakaran D. , McMorrow D. F. , Sahle Ch. J. 
Published: October 2024

We report on a resonant inelastic x-ray scattering study on a single crystal of a nonstoichiometric pyrochlore iridate Tb2+xIr2−xO7−y (x≃0.25) that magnetically orders at TN≃50 K. We observe a propagating gapped magnon mode at low energy and model it using a Hamiltonian consisting of a Heisenberg exchange [J=16.2(9)meV] and Dzyaloshinskii-Moriya interactions [D=5.2(3)meV], which shows the robustness of interactions despite Tb stuffing at the Ir site. Strikingly, the ratio D/J=0.32(3) supports possible nontrivial topological magnon band crossing. This material may thus host coexisting fermionic and bosonic topology, with potential for manipulating electronic and magnonic topological bands thanks to the d−f interaction.

Published by the American Physical Society
2024
Women’s career aspirations: a mechanism of family care work conflict and motivation to continue work
Authors: Ahmed Ishfaq , Riaz Samina 
Published: October 2024

PurposeIn closely knitted eastern societies (e.g. Pakistan), women tend to work for their families, and career is a volunteer choice. The working women often face issues in balancing between these roles and often family pressures influence their work i.e. family care work conflict (FCWC). By valuing the prevalent issue of FCWC, this study aims to identify its relationship with the motivation to continue work (MCW) through mediation of career self-efficacy (CSE) and future time perspectives (FTP).Design/methodology/approachData for the current study are collected from a women sample working in education, health, law firms and banking sector. All in all, 309 completely filled questionnaires were used for analysis purposes.FindingsThe findings of the study reveal that women with high FCWC have low MCW, and CSE partially mediate the relationship. Moreover, FTP moderates the relationship.Originality/valueThe study contributes to literature by considering the mechanism of CSE and FTP between FCWC and MCW. Moreover, a women sample from a closely knitted eastern culture also provides some interesting findings.
Assessing the role of risk-driven entrepreneurial actions in achieving sustainable development goals 1 and 2 in Africa: does democracy matter?
Authors: Tiba Sofien , Omri Waleed , Chishti Muhammad Zubair 
Published: October 2024

PurposeThis study rigorously examines the complex interplay between entrepreneurial risk-taking and the achievement of sustainable development goals 1 and 2, which focus on eradicating poverty and hunger, respectively. By conducting a comprehensive review of existing literature and empirical data, the research aims to unravel the direct impact of risk-oriented entrepreneurial activities on poverty and hunger alleviation. Moreover, it seeks to investigate the moderating role of democratic governance in shaping these effects within the context of African economies.Design/methodology/approachBy employing a Panel Smooth Transition Regression (PSTR) model and using annual and balanced panel data for 20 African countries over 21 years, we examine a potential regime switching as an original framework in the analysis of the curvilinear relationship between risk-driven entrepreneurial actions and sustainable development goals 1 and 2.FindingsOur empirical results confirm the presence of a specific threshold above which risk-oriented entrepreneurial actions proactively tackle poverty and hunger issues. The results also show that entrepreneurship associated with a good level of democracy is the fair tradeoff toward eradicating extreme poverty and hunger by the 2030th United Nations (UN) deadline.Originality/valueThis study offers novel insights into the role of entrepreneurial risk-taking at the country level in achieving sustainable development goals 1 and 2. It advances research on entrepreneurship and sustainable development by demonstrating how a strong risk culture among entrepreneurs might make regions more developed while building on suitable institutional quality.
Unearthing hidden agendas: carbon emissions and corporate tax strategies
Authors: Lassoued Naima , Souguir Zahra , Khanchel Imen 
Published: October 2024

Purpose
This study aims to investigate the relationship between carbon risk and tax avoidance practices among American firms.

Design/methodology/approach
The research examines 854 American firms over the period from 2015 to 2021. A two-stage least squares regression technique with instrumental variables is used to address potential endogeneity concerns.

Findings
The study shows that an increase in carbon risk is associated with higher tax avoidance, particularly through Scope 1 and Scope 2 emissions. These findings are robust across various metrics used to measure carbon risk and align with the insights derived from agency theory.

Research limitations/implications
Although focusing on American firms provides a consistent regulatory context, it may limit the generalizability of findings to other contexts. The study’s implications suggest that policymakers and managers should consider the interplay between environmental and tax policies in their decision-making processes.

Originality/value
This study contributes to the literature by extending the understanding of determinants of corporate tax avoidance by introducing carbon risk as a significant factor. The results provide valuable insights for stakeholders into the evolving dynamics of corporate environmental and fiscal responsibilities.
Digitalization and expatriate cross-cultural adjustment: the role of mobile apps
Authors: Wang Yuling , Lockett Martin , Zhou Abby Jingzi 
Published: October 2024

PurposeThis study explores the role of digitalization, especially mobile apps, in expatriate cross-cultural adjustment. The role of digitalization is under-researched and under-recognized in the current literature on global mobility, but is becoming a significant factor in expatriate cross-cultural adjustment.Design/methodology/approachAs the research is exploratory, it uses qualitative methods, specifically in-depth interviews and rigorous thematic analysis. It is based on 31 respondents from 16 higher education organizations across 10 cities in five provinces/municipalities in China, a country with one of the highest levels of digitalization in daily life.FindingsThe most significant finding is that mobile apps are central to expatriate cross-cultural adjustment in China. Such apps both enable adjustment if used actively and hinder adjustment significantly if resisted or not used effectively. However high motivation is required to cope with the incompatibility between the infrastructure of mobile apps in China and expatriates’ previous experiences.Research limitations/implicationsThis study is based on expatriate academics in China, where digitalization is widespread and local apps rather than international apps are predominant. Hence expatriates may feel a greater impact of digitalization on daily life and work than in less digitalized societies. A major implication is that digitalization should be considered as a potentially significant factor in expatriate cross-cultural adjustment.Practical implicationsHost country governments, employers, app developers and expatriates, all need to consider the use of mobile apps in cross-cultural adjustment and retention of expatriates.Originality/valueThis study identifies the role of digitalization, especially mobile apps, in expatriate cross-cultural adjustment in a highly digitalized environment, which has not been recognized in previous research. It proposes the concept of “digital distance” that should be considered alongside “cultural distance” in the context of expatriate cross-cultural adjustment.
Does financial expertise influence Islamic bank risk-taking?
Authors: Umar Umar Habibu , Al-Faryan Mamdouh Abdulaziz Saleh , Osemy Ahmed Zakaria Zaki 
Published: October 2024

PurposeThis study investigated how the financial expertise of the board of directors, risk management committee (RMC), audit committee (AC) and Shariá Supervisory Board (SSB) influences the risk-taking of Islamic banks.Design/methodology/approachThe study utilized unbalanced panel data for a sample of 43 full-fledged Islamic banks from 15 countries over 12 years (2010–2021). We employed feasible generalized least squares (FGLS) and heteroskedastic panels corrected standard errors (HPCSE) regression regressions as the primary estimation methods and used a two-step system generalized method of moments (GMM) estimator for robustness checks.FindingsThe results indicate that board financial expertise decreases insolvency and credit risks. Similarly, AC financial expertise and SSB financial expertise reduce insolvency and portfolio risks but increase credit risk. In contrast, RMC financial expertise raises insolvency risk. The remaining relationships are statistically insignificant.Research limitations/implicationsDue to the lack of disclosure regarding the educational and professional background of the board and committee members in the annual reports of some Islamic banks, this research used a sample of only 43 full-fledged Islamic banks operating in fifteen countries from 2010 to 2021.Practical implicationsThe findings can assist both local and international regulators in revising corporate governance codes and risk management guidelines in such a way as to ensure that the financial experts appointed to the board, AC, RMC and SSB, are capable of controlling excessive risk-taking behavior in Islamic banks.Originality/valueThis study contributes to the literature by providing comprehensive empirical evidence that corporate governance financial expertise influences the risk-taking behavior of Islamic banks.
The social entrepreneurship value cycle: generation, appropriation, devolution and transformation of sustainable value
Authors: Nascimento Leandro da Silva , Silva Diego S. , Chim-Miki Adriana Fumi , Costa Júnior Júlio César da , Salazar Viviane Santos 
Published: October 2024

Purpose
Social entrepreneurship literature emphasizes the creation of social value for society from three main concepts – generation, appropriation and devolution - that form a value cycle. This paper aims to analyse how social enterprises operationalize this cycle to create positive social impact.

Design/methodology/approach
This study uses a multi-case approach, conducting semi-structured interviews with founders of Brazilian social enterprises.

Findings
This study empirically supports the existence of the value cycle and identifies an additional stage –value transformation – emerging from the data. While the initial three stages occur within social enterprises, value transformation unfolds within served communities. This stage not only facilitates the conversion of value types (e.g. social to economic or environmental) but also stimulates the formation of new social enterprises. Consequently, this paper proposes a comprehensive social entrepreneurship value cycle encompassing generation, appropriation, devolution and transformation of value.

Originality/value
This paper contributes to clarifying concepts and mitigating theoretical ambiguities surrounding social value creation in the context of social entrepreneurship. It provides a framework for understanding the underlying principles of each stage in the value cycle, thereby empowering scholars and practitioners to enhance the innovative mission of social enterprises and drive social change within underserved communities.
Examining graduate student perspectives on supervision and peer mentoring across four professional faculties
Authors: Jacobsen Michele , Neutzling Nicole , Lorenzetti Liza , Oddone Paolucci Elizabeth , Nowell Lorelli , Clancy Tracey , Freeman Georgina , Lorenzetti Diane L. 
Published: October 2024

Purpose
The purpose of the study was to examine graduate student perspectives on the common and unique roles peer mentors and supervisors play in supporting student success and wellbeing during their program.

Design/methodology/approach
A qualitative research design involving semistructured interviews with 62 thesis-based masters and doctoral students from four professional faculties, Education, Medicine, Nursing and Social Work, at a large public research-intensive university in Canada.

Findings
Findings transcend the four disciplines of study. Communities of support are described that involve both supervisors and peers in combination, clusters of meaning by supervisory paradigm are identified and original findings presented that expand upon the learning alliance framework by explicitly considering the role of peer mentors in graduate student success.

Research limitations/implications
While supervisors bear primary responsibility for fostering effective research-based relationships, this study’s findings strengthen the argument that mentoring and advising of graduate students is most effective when conducted within a collaborative community of support that involves learning alliances among faculty, peers, program staff and academic leaders across the institution.

Practical implications
A four-pronged approach to graduate education that emphasizes the collective responsibility of institutions, programs, supervisors and students in creating a supportive ecosystem for holistic graduate student academic success and wellbeing is recommended.

Social implications
Key argument that it is essential to embrace a collaborative and community of support mindset, where multiple stakeholders actively contribute to the wellbeing and academic development of graduate students throughout their programs.

Originality/value
A cross-disciplinary perspective is offered on the importance of both supervisors and peers in assisting thesis-based graduate students to successfully navigate academic, social and personal journeys through graduate school.
Case report: A novel high‐dose intravenous immunoglobulin preparation for the treatment of severe pemphigus vulgaris failing standard therapy
Authors: Wiedenmayer Nadine , Hogrefe Katharina , Mihalceanu Silvia , Winkler Julia K. , Enk Alexander H. 
Published: October 2024

AbstractPemphigus vulgaris (PV) is a severe autoimmune bullous dermatosis that is characterized by autoantibodies against epidermal adhesion proteins causing painful mucosal and skin blistering. Standard treatments for PV include corticosteroids, steroid‐sparing immunosuppressants, or intravenous monoclonal anti–CD20‐antibody therapy. The European guidelines suggest high‐dose intravenous immunoglobulin (IVIg) therapy as a promising approach for severe or treatment‐resistant cases. We report on a 65‐year‐old woman with severe and recurrent disease who achieved long‐term disease stabilization with IVIg treatment. Because of recurrent fatigue and headache, the patient was switched to an alternative IVIg preparation with a novel manufacturing process, thus ensuring high purity and better tolerability. We observed excellent efficacy, yet side effects remained largely unchanged. Further studies are necessary to evaluate the long‐term efficacy and tolerability of this new IVIg preparation.
A case of chronic spontaneous urticaria with wheals lasting for more than a week
Authors: Morioke Satoshi , Moriwaki Masaya , Tanaka Akio , Hide Michihiro 
Published: October 2024

AbstractUrticaria is characterized by the development of wheals which usually disappear within a day, and are not present beyond a few days. A 58‐year‐old man began to develop edematous, partially ring‐shaped erythematous lesions accompanied by severe body itching without any particular cause, approximately 2 months before his first visit to our hospital. Each rash emerged as being about 5 mm in diameter, gradually enlarging over several days, and disappeared in up to 10 days. Despite oral treatment with several antihistamines and 10 mg of prednisolone, there was no improvement. Most eruptions disappeared without a trace, but the erythema that appeared on the palms left desquamation. The patient had a history of shellfish allergy, but otherwise no atopic diseases. Drug eruption was ruled out due to a lack of regular taking other medications. Histopathological findings of the skin lesions showed moderate lymphocytic and few eosinophilic infiltrates with edema, but no evidence of vasculitis. Despite the concomitant use of two second‐generation antihistamines and montelukast, the rash did not improve. The symptoms began to improve following oral intake of 1.5 mg of betamethasone, which was tapered off with the addition of 150 mg of cyclosporin. The use of all medications was stopped at 4 months from the first visit without recurrence. Wheals of chronic spontaneous urticaria may last for longer than a week without apparent histopathological findings of vasculitis.
Thermal conditions alter the mating behaviour of males in a polygynous system
Authors: Levine Rebecca L. , Kroger Bart , Monteith Kevin L. 
Published: October 2024

Abstract

Males in polygynous systems may be facing a trade‐off between the traits that enhance reproductive success and the need to cope with environmental change. To secure mates, males invest into large bodies, lavish ornaments and costly activities, but these investments may be incompatible with future environments. As climatic change intensifies, thermal stressors could be disrupting the energy‐intensive pathways that historically have yielded mating opportunity.

We evaluated how traits associated with social dominance interacted with environmental conditions to shape mating behaviour and opportunity in moose (Alces alces), a heat‐sensitive species in which southern populations live at the edge of their thermal tolerance. We anticipated that males with favourable characteristics (e.g. age, weaponry) would allocate more to reproduction, resulting in increased mating opportunity. We expected that warm temperatures would limit reproductive effort, especially as age and weapon size increased.

We quantified mating tactics, effort, and opportunity for male moose ranging in age from 1.5 to 11.5 years. We used hidden Markov models to detect mating tactics, accelerometer data to quantify movement effort, and proximity to females as a proxy for mating opportunity. We modelled these mating dynamics as a function of age, weapon size, and ambient temperature.

Warm temperatures exaggerated age‐related differences in time and effort allocated to reproductive movement. Heat disproportionately limited reproductive effort in old males, the ages that also had the greatest mating opportunity. Even though warm temperatures altered mating behaviour, they did not reduce mating opportunity. Across temperatures, mating opportunity was highest in prime‐age and old males, yet time and effort devoted to reproductive movement decreased with age.

Climate change, which is increasing autumn temperatures, may increase variation in reproductive effort across ages and depress the movement of old males, who are typically the primary breeders. The discrepancy between behaviour and opportunity suggests that movement is not a reliable pathway to reproduction and emphasizes the advantages of energy‐saving strategies, especially as environments become more taxing for heat‐sensitive species. We reveal the limitations of movement effort in polygynous mating strategies and the susceptibility of this critical life history stage to environmental change.

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