bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schneiderian membrane adult vasculogenesis evaluated by CD31 and CD34 expression and morphological arrangement
Authors: Derjac-Arama Andreea-Ioana , Sarafoleanu Codrut , Rusu Mugurel Constantin , Vereanu Anca 
Published: November 2015

Abstract
Background. Few studies approached the process of blood vessels formation in the Schneiderian membrane. We aimed at investigating by immunohistochemistry the processes that are responsible for forming new blood vessels in the human Schneiderian membrane.
Material and methods. We applied CD31 and CD34 markers on bioptic samples gathered from eight adult patients negative for malignant pathologies. Filopodia-projecting endothelial tip cells (ETCs) were found and indicated processes of sprouting angiogenesis. Also, CD31-expressing monocyte-derived cells were found being involved in processes of vasculogenesis. These cells were projecting filopodia, thus being assessed as endothelial progenitor tip cells (EpTCs). Aggregates of CD31+ EpTCs were also analyzed. Further stages of lumen acquisition and large diameter vessels formation, specific for vasculogenesis, were evaluated.
Results. It resulted that, specifically within the maxillary sinus mucosa, vascular remodelling is equally ensured by adult vasculogenesis and sprouting angiogenesis.
Conclusion. This is, to our knowledge, the first evidence of adult vasculogenesis in the maxillary sinus mucosa, supported by bona fide bone marrow-derived CD31+ cells. The guidance mechanism of EpTCs protrusions needs further investigations for finding similarities, or dissimilarities, with the endothelial tip cells prolongations.
Thrombospondin-1 is a glucocorticoid responsive protein in humans
Authors: Barclay Johanna L , Petersons Carolyn J , Keshvari Sahar , Sorbello Jane , Mangelsdorf Brenda L , Thompson Campbell H , Prins Johannes B , Burt Morton G , Whitehead Jonathan P , Inder Warrick J 
Published: November 2015

ObjectiveThrombospondin-1 (TSP1) is a matricellular protein whose gene expression has previously been shown to increase acutely after exposure to dexamethasone in vitro. The aim of this study was to determine if TSP1 is altered by acute and chronic states of glucocorticoid excess in human subjects.Design and methodsThree studies have been undertaken to assess the difference or change in TSP1 in response to altered glucocorticoid activity: i) an acute interventional study assessed the effects of a single 4 mg dose of dexamethasone in 20 healthy volunteers; ii) a cross-sectional study compared plasma TSP1 in 20 healthy volunteers and eight patients with Cushing's syndrome; iii) an interventional study assessed the effect on plasma TSP1 of an increase in hydrocortisone dose from ≤20 mg/day to 30 mg/day for 7 days in 16 patients with secondary adrenal insufficiency.ResultsIn healthy volunteers, 4 mg dexamethasone significantly increased peripheral blood mononuclear cell (PBMC) TSP1 mRNA levels (P<0.0001) and plasma TSP1 concentrations (P<0.0001), peaking at 12 h. Median (interquartile range) plasma TSP1 was higher in Cushing's, 638 (535–756) ng/ml, than in healthy volunteers, 272 (237–336) ng/ml (P<0.0001). Plasma TSP1 >400 ng/ml diagnosed Cushing's syndrome with sensitivity of 100% and specificity of 85%. The higher hydrocortisone dose increased plasma TSP1 from 139 (86–199) to 256 (133–516) ng/ml, (P<0.01) in patients with secondary adrenal insufficiency.ConclusionsTSP1 is a glucocorticoid responsive protein in humans. Further research is required to determine if plasma TSP1 has a role as a glucocorticoid biomarker.
Prevalencia de potenciales interacciones farmacológicas de Azitromicina en Colombia, 2012-2013
Authors: Machado Alba Jorge Enrique , Martinez Dayron , Gomez-Suta Daniela 
Published: November 2015

<p><strong>Objetivos</strong> Determinar la prevalencia de potenciales interacciones farmacológicas entre azitromicina y diferentes antiarrítmicos del grupo IA y III en una base de datos de prescripción de medicamentos a nivel nacional durante el año 2012-2013.</p><p> </p><p><strong>Métodos </strong>Estudio retrospectivo a partir de una base de datos poblacional de dispensación de medicamentos. Se extrajeron datos de los pacientes que recibieron azitromicina desde 1 de enero de 2012 a 30 junio de 2013, al igual que pacientes que recibieron este antibiótico en combinación a otros medicamentos con demostrado riesgo de provocar arritmias cardíacas al usarse concomitantemente. Se establecieron frecuencias y proporciones.</p><p><strong>Resultados</strong> Se identificaron 13 859 pacientes que recibieron azitromicina sola o en combinación con otros medicamentos. El tiempo promedio de uso fue 4,5±0,9 días; Un total de 702 pacientes (5,1 %) recibieron azitromicina más otros 19 fármacos de potencial riesgo. Los más frecuentemente asociados fueron: loratadina (77,1 %), difenhidramina (16,5 %) y amitriptilina (8,1 %). Las combinaciones con un solo medicamento fueron las más frecuentes (n=533, 75,9 %), con predominio de azitromicina+loratadina. El máximo número de fármacos combinados fue seis (n=2, 0,3 %).</p><p><strong>Conclusiones</strong> La identificación mediante bases de datos poblacionales la prescripción de medicamentos, es una manera eficaz de encontrar potenciales interacciones entre estos. La frecuencia de potenciales interacciones entre azitromicina y otros fármacos es común en pacientes colombianos. Se debe estimar el riesgo de ocurrencia de eventos cardiacos adversos. </p>
Exploración de modelos para la evaluación del impacto económico, social, político y científico de la investigación en salud
Authors: Macias Angel Beatriz Del Pilar 
Published: November 2015

<p>La investigación en salud incide sobre la salud de las poblaciones. El presente ensayo realiza un acercamiento a los marcos y modelos empleados por los países desarrollados para la evaluación del impacto de las investigaciones en salud, por medio del análisis documental. De esta manera se identifican dos ejes orientadores de análisis: uno de enfoque y el otro de énfasis, en los que se relacionan los modelos publicados, sus orígenes, sus alcances y sus usos. Esto permite conocer las características que poseen y los ámbitos en los cuales Colombia podría implementarlos. El modelo de evaluación “retorno de la inversión” es un modelo que permite seguir el proceso y los resultados de investigación, por medio de la categorización multidimensional de los impactos de la investigación. </p>
Literature and Information
Authors: Arata Stephen 
Published: November 2015

The Tenth and final “anchor standard for reading” in the common core state standards defines as “college and career ready” a student who can “[r]ead and comprehend literary and informational texts independently and proficiently” (35). I want to remark on just one aspect of this worthy if blandly unremarkable goal. The distinction between “literary” and “informational” texts has the sanction of common sense, but, like many commonsense notions, it cloaks some knotty issues. For the authors of the standards, “literacy” requires mastering two different if closely related sets of reading skills. One lays the groundwork for “understanding and enjoying complex works of literature,” while the other is needed “to pick carefully through the staggering amount of information available today in print and digitally” (3). Pedagogically, one is the job of the “English language arts teacher,” the other the responsibility of “teachers of history/social studies, science, and technical subjects” (8).The axiom that literature cannot be read in the same way as other forms of writing is by no means universally held, but it has long governed the teaching of reading in high school and college classrooms. In ways that humanists can find heartening, the Common Core standards valorize the traits that reading literature both requires and strengthens: habits of attention and intellectual rigor; the refinement of sensibility and emotional response; the ability to analyze, to synthesize, to discriminate, to evaluate. Such virtues travel well, too. The authors of the standards recognize that students who have mastered literary reading skills are better equipped to meet the challenges posed by texts in other disciplines.
Cooperación y consumo de agua en hogares
Authors: Gil Mateus Edwin Oswaldo 
Published: November 2015

<p>Las decisiones de consumo de agua potable de los hogares son interdependientes, en búsqueda del bienestar individual, tácitas y sin incentivos para desviarse. Algunos hogares pueden hacer uso moderado del recurso, mientras que otros realizan gastos desmedidos. Aquellos que realizan consumos moderados conociendo que otros lo hacen en exceso no tienen estímulos para continuar la moderación; entre tanto, los que consumen agua potable en exceso saben que otros son moderados, así que tampoco tienen razón alguna para disminuir. Dado lo anterior, se configura un dilema social de recursos de uso común (RUC), en el que hay un consumo desmesurado, ejerciendo mayores presiones sobre los ecosistemas abastecedores. Sin embargo, mediante un esquema de interacción reproducido indefinidamente, tal dilema social se resuelve introduciendo un concepto de cooperación en el que todos los hogares obtengan la máxima satisfacción individual y la sociedad reduzca la presión sobre las fuentes hídricas.</p>
Propuesta metodológica para la construcción de un ranking de emisores en la Bolsa de Valores de Colombia
Authors: Hernández José Armando 
Published: November 2015

<p>Este documento presenta el desarrollo y la evolución de las teorías financieras asociadas a los métodos de valoración. Evalúa el comportamiento en el mercado de las acciones que cumplen con algunas condiciones metodológicas y que hacen parte de las canastas IGBC, COLCAP y COL20, teniendo en cuenta los planteamientos de Modigliani y Miller, Markowitz, Sharpe, Damodaran, entre otros. También describe metodologías para la valoración de empresas basadas en estados financieros como el balance general, los estados financieros y los flujos de caja. La propuesta metodológica consiste en la elaboración de dos matrices: una presenta un diagnóstico a través del análisis del riesgo y la rentabilidad de las acciones objeto de estudio; otra analiza la conformación de la estructura del capital, así como su rendimiento esperado. Finalmente, se construye un ranking basado en el diagnóstico del mercado y la estructura de capital de las empresas emisoras de acciones.</p>
Hacia una nueva visión de la política económica: discusión en torno al nuevo paradigma propuesto por David Romer en “Keynesian Macroeconomics without the LM Curve”
Authors: Penagos Rozo Marco Leonardo 
Published: November 2015

<p>Los nuevos keynesianos (NK) referencian una postura avanzada respecto al paradigma tradicional del equilibrio IS-LM que, como herramienta, satisfizo explicaciones de política económica para su momento. El modelo tuvo críticas como las de ser considerado simplificacionista, no contar con fundamentos microeconómicos, entre otros aspectos. Quizá en los momentos que se presentan: Keynes, en 1936, con la Teoría general; Hicks, en 1937, con Mr. Keynes y los clásicos; Samuelson, en 1948, y años subsecuentes, con su obra Economía, proveyeron elementos importantes en el equilibrio. Sin embargo, hacía falta un nuevo enfoque para el siglo XXI y es el propuesto por David Romer. El fin de este artículo es hacer una revisión inicial que permita entender de qué manera algunos aspectos de la política económica se vinculan como elementos del crecimiento económico.</p>
Variaciones e índice simétrico de las variables cinéticas de caninos normales en el trote
Authors: Arias Serrato Sergio Andrés , De Faria Rezende Cleuza Maria , Menzel Hans Joachim , Doretto João Vicente , Ferreira Mantovani Plinio , Goulart de Oliveira Letícia , Pérez Osório Jair , Rivas López Piedad Cristina , Álvarez Ramírez Iván Darío 
Published: November 2015

Los índices de simetría en la marcha de caninos han sido escasamente reportados. Falta consenso y se desconoce el efecto de la normalización en los resultados, sobre todo en la ortogonal craneocaudal. La cinética de la marcha en el ciclo de trote de quince perros mestizos se analizó mediante una plataforma de fuerza amplificada buscando determinar la simetría en la marcha. Se determinó el índice de simetría (IS) bajo dos sistemas de normalización de los datos en caninos entonces: normalización por el peso corporal y normalización por las características morfométricas bidimensionales de los miembros. Se obtuvieron variables dinámicas primarias de estudio como el IS en el tiempo e impulso hasta el pico de fuerza y otras variables secundarias como resultado de la amplificación de la plataforma de fuerza. Los valores para cada ensayo se utilizaron para calcular media, desviación estándar y coeficiente de variación entre individuos y entre los animales. Las variables en la ortogonal craneocaudal fueron más irregulares y asimétricas que en la ortogonal vertical y tuvieron una menor correlación con la normalización por la masa corporal. La normalización por el peso corporal mostró una mayor eficacia que la normalización por las características morfométricas bidimensionales de los miembros ratificándose su uso en estudios de cinética en caninos. Se determinó que los índices de simetría no deben ser inferiores a 0,90 y 0,75 en las ortogonales vertical y craneocaudal respectivamente. Valores superiores a los descritos son valores aceptables para caninos normales y sin alteraciones ortopédicas.
Biomarcadores de la falla cardiaca en pequeños animales
Authors: Álvarez Iván , Uribe Alejandra , Duarte Sandra 
Published: November 2015

Tradicionalmente, la evaluación de la función cardiaca se realiza mediante la electrocardiografía, radiografía y ecocardiografía para la evaluación de los pacientes con insuficiencia cardiaca, la cual no solo resulta de una sobrecarga de volumen o presión, o de lesiones estructurales, sino también de una compleja interacción entre genética, inflamación, factores neurohormonales y bioquímicos que actúan en los miocitos cardiacos, el intersticio cardiaco o ambos. Un aumento del número de enzimas, hormonas, sustancias biológicas y otros marcadores de esfuerzo cardiaco y mal funcionamiento, así como lesiones de los miocitos pueden ser medidos en sangre y son denominados colectivamente como biomarcadores, los cuales son de importancia clínica. Esta revisión se centra en los biomarcadores derivados de la sangre o la orina que no sean los niveles séricos de hemoglobina, electrolitos, enzimas hepáticas y creatinina, que se determinarán como parte rutinaria de la atención clínica para el diagnóstico de las enfermedades cardiacas en pequeños animales.
Integrated Reservoir Analysis for Optimizing Production When There is High Potential for Sanding
Authors: Bravo O. , Mora L. , Rabanal J. , Vallejo R. , Pastrana W. , Salas J. , Lomas J. , Tapia D. , Almeida R. , Paz F. 
Published: November 2015

Abstract
The objective of this work is to describe a comprehensive approach integrating static and dynamic data along with rock mechanical properties to optimize well production and avoiding premature sanding problems.
The proposed procedure was used to estimate the production potential of a slanted well in the Napo M1 Sandstone which presents a high sanding potential. Starting with a detailed petrophysical analysis along with advanced sonic scanner data processing, a Mechanical Earth Model (MEM) was built. In addition to the MEM an advanced perforating design and a grain size laboratory test were finally used to develop a Sanding Model Analysis that was used to predict and measure severity of sanding problems under specific static and dynamic conditions.
This holistic approach was used to determine the critical drawdown at which sanding problems could occur. A tailored critical drawdown was determined based on grain size; it was determined that small grains will start moving with drawdown of around 790 psi, while larger grain sizes will move at a drawdown close to 1790 psi. The grain size distribution per sample was then used to determine the level of severity and safe and non-safe drawdown ranges. Finally a safe bottom hole flowing pressure of ~1100 psi or drawdown of ~1190 psi with a 90% safety of no sanding problems was selected as the optimum dynamic condition for producing the well with minimum sanding risk.
The well was put into production using the recommended critical drawdown. No sand production was observed at the surface. After five months of production (from 30-Aug-2014 to 4-Jan-2015), the well had accumulated 9 bbls of sand (equivalent weight: 3650 kg), lower than expected (not showing on surface) and average production was 1126 bbls of fluid per day (1075 bbls of Oil per day, 4.53% water cut), significantly higher than neighbor wells.
This methodology accurately predicted the critical drawdown at which a well with potential sanding problems must be produced. It also provided highly valuable information for a better completions design and decision making on whether to use a sand control equipment or not, representing cost savings and optimizing production.
Considerations for Production Forecasting and Field Development in an Under Developed Field in a Geologically Complex Reservoir System: Chicontepec Basin Example
Authors: Rangel-German E. , Dordoni F. , Hernández G. Franco , Clem D. , Nogales M. Cuba , Ruhs J. C. 
Published: November 2015

Abstract
The exploitation of the under developed fields in the Chicontepec basin is difficult mainly due to uncertainty in production forecasts as a result of complex geology, variations in fluid properties, and lack of data quality. Under these circumstances sole use of decline curve analysis is not sufficient, and it includes major uncertainty with respect to well performance. Along these lines the focus of this work is to present an efficient methodology using model-based analysis within a probabilistic framework as the foundation for field production forecasting to find better areas for development in the Chicontepec basin.
The methodology includes constructing a well/reservoir model based on future development considerations in this geologically complex environment. An experimental design procedure is used to account for the uncertainty in both reservoir and well properties. Using analogous field analysis and available information (PVT, production data, geological information), distributions for key parameters, such as permeability, thickness, area; were determined and the statistical distribution of Estimated Ultimate Recovery (EUR) values were found using the numerical model-based simulation. The field development methodology is based on well spacing analysis, targeted production locations, and various well orientations for the geologically complex reservoir system. The numerical model-based derived profiles are projected throughout the under developed field with the field development methodology to complete the full field production forecast.
A response surface equation was observed to relate the reservoir properties, fluid properties, and well completion properties of the numerical based-model to the EUR values found from the proposed methodology. Running a Monte Carlo simulation with the response surface equation and probabilistic distribution of key parameters P90, P50 and P10 EUR values and associated type well profiles for the full field development scenarios were determined. Experimental decline curve analysis of a developed field in the Chicontepec Basin predicts oil recovery factors from 6% to 13%. Following the methodology presented in this work, oil recovery factors of the same field were found to be 6% to 15%. Based on comparisons of the presented methodology and empirical decline curve analysis, the experimental design framework for analysis offers a viable option to decline curve analysis for full field production forecasting when little or unreliable production data is available.
This work provides a thorough description of a workflow for a probabilistic approach to full field production forecasting in a geologically complex reservoir system such as the Chicontepec basin.
Natural-Fracture Reactivation in Shale Gas Reservoir and Resulting Microseismicity
Authors: Shahid Arshad Shehzad Ahmad , Wassing Brecht B. T. , Fokker Peter A. , Verga Francesca 
Published: November 2015

Summary
A geomechanical and fluid-flow coupled model was developed to simulate natural-fracture-network reactivation during hydraulic-fracturing treatments in shale gas reservoirs. The fractures were modelled using the continuum approach in a commercial finite-difference code, labeled the “softening ubiquitous joints” model, with randomly distributed strength parameters to describe heterogeneity along the fracture plane. The models allow for intersecting fractures to represent realistic scenarios. The permeability values in the fractures are dynamically updated during the simulations together with the reversible tensile opening because of elastic response and irreversible shear opening caused by plastic deformations. The reactivation of the fracture network resulted in high permeability along these fracture planes. The developed model can predict microseismic events caused by slip on the fracture planes. The magnitude levels of these microseismic events are comparable with the levels observed in events monitored by use of geophone arrays during hydraulic-fracturing treatments for different shale gas reservoirs.
Tectorigenin inhibits Caco-2 human colon cells via NF-κB pathway suppression
Authors: Dai Xiao-Yu , Yu Yong-Ming , Kong Zheng-Fang , Cao Yi-Sheng , Huang Dan-Dan , Hu Xiao-Rong , Huang Zuo-An , Xie Yang-Yang , Zhang Shun 
Published: November 2015

<p class="Abstract">Effective immunomodulator and pro-inflammatory cytokine, Tumor necrosis factor-α (TNF-α) are considered to be responsible for connecting autoimmune pathological process and contagious diseases. TNF-α stimulates the C-X-C motif chemokine 10 (CXCL10) expression that is participated in migration of tumor, metastasis, and invasion. Tectorigenin, an o-methylated isoflavone, is present as a major portion in the Iris tectorum rhizomes. In this study, we investigated the tectorigenin effects as an anticancer drug. The obtained results showed that tectorigenin hinders the invasion of human colon cancer cells (Caco-2). We used reverse transcription PCR, q-PCR and enzyme linked immunosorbent assays to test whether the tectorigenin is involved in the inhibition of TNF-α induced CXCL-10 expression in the Caco-2 cell lines. Further, we tested TNF-α induced NF-κB activity using the tectorigenin. Collective results showed that tectorigenin inhibits the CXCL10 production by using TNF-α via NF-κB inhibition.</p><p> </p>
Big Data and Analytics in Healthcare
Authors: Gao G. , Koch S. , Tan S. S. -L. 
Published: November 2015

SummaryThis editorial is part of the Focus Theme of Methods of Information in Medicine on “Big Data and Analytics in Healthcare”.The amount of data being generated in the healthcare industry is growing at a rapid rate. This has generated immense interest in leveraging the availability of healthcare data (and “big data”) to improve health outcomes and reduce costs. However, the nature of healthcare data, and especially big data, presents unique challenges in processing and analyzing big data in healthcare. This Focus Theme aims to disseminate some novel approaches to address these challenges. More specifically, approaches ranging from efficient methods of processing large clinical data to predictive models that could generate better predictions from healthcare data are presented.