bluuebunny/crossref_metadata_2025_split huggingface dataset:
Archaeological prospection of a specialized cooking‐pit site at Lunde in Vestfold, Norway
Authors: Gustavsen Lars , Cannell Rebecca J.S. , Nau Erich , Tonning Christer , Trinks Immo , Kristiansen Monica , Gabler Manuel , Paasche Knut , Gansum Terje , Hinterleitner Alois , Poscetti Valeria , Neubauer Wolfgang 
Published: September 2017

AbstractIn September 2010, an exceptionally large cooking‐pit site was discovered by means of geophysical prospection at Lunde in Vestfold County, Norway. The site contains in excess of 1000 cooking‐pits and is, to date, one of the largest of its kind discovered in Scandinavia. Features known as cooking‐pits are ubiquitous on Northern European archaeological sites. Despite research spanning decades, however, the true function and role of this rather non‐descript feature type is still debated. Using the results from geophysical prospection, soil analysis, ground‐truthing and excavation, this article aims to better understand this phenomenon by evaluating the physical properties revealed from the data, and setting this exceptional site in a wider cultural‐historical context. The wider, landscape context is accessible from the large‐scale, high‐resolution, landscape archaeological prospection case‐study approach conducted by Ludwig Boltzmann Institute for Archaeological Prospection and Virtual Archaeology (LBI ArchPro). The results suggest that the multi‐method approach is essential in such cases, as it is able to challenge the assumptions of the blanket interpretations often applied, and put the site in a cultural and environmental context.
Identification Recurrent Type 2 Fuzzy Wavelet Neural Network and L2‐Gain Adaptive Variable Sliding Mode Robust Control of Electro‐Hydraulic Servo System (EHSS)
Authors: Chen Xiangjian , Li Di , Yang Xibei , Yu Yuecheng 
Published: September 2017

AbstractAn electro‐hydraulic servo system (EHSS) is a kind of system with the characteristics of time‐variant, serious nonlinearity, parameter and structural uncertainty, and uncertain load disturbance in most cases. These characteristics make it very difficult to realize highly accurate control by conventional methods. In order to solve the above problems, this paper introduces a recurrent type 2 fuzzy wavelet neural network to approximate the unknown nonlinear functions of the dynamic systems through tuning by the desired adaptive law. Based on the identification by recurrent type 2 fuzzy wavelet neural network, a L2 gain design method, combining gain adaptive variable sliding mode control with H infinity control, is proposed for load disturbance, thereby accommodating uncertainties that are the main factors affecting system stability and accuracy in EHSS. In this algorithm, a recurrent type 2 fuzzy wavelet neural network is employed to evaluate the unknown dynamic characteristics of the system and gain adaptive variable sliding mode control to compensate for evaluating errors, and H infinity control to suppress the effect on system by load disturbance. The experiment results show that the proposed system L2 gain design method can make the system exhibit strong robustness to parameter variation and load disturbance.
Species‐related exposure of phase II metabolite gemfibrozil 1‐O‐β‐glucuronide between human and mice: A net induction of mouse P450 activity was revealed
Authors: Luo Min , Dai Manyun , Lin Hante , Xie Minzhu , Lin Jiao , Liu Aiming , Yang Julin 
Published: September 2017

AbstractGemfibrozil is a fibrate drug used widely for dyslipidemia associated with atherosclerosis. Clinically, both gemfibrozil and its phase II metabolite gemfibrozil 1‐O‐β‐glucuronide (gem‐glu) are involved in drug–drug interaction (DDI). But the DDI risk caused by gem‐glu between human and mice has not been compared. In this study, six volunteers were recruited and took a therapeutic dose of gemfibrozil for 3 days for examination of the gemfibrozil and gem‐glu level in human. Male mice were fed a gemfibrozil diet (0.75%) for 7 days, following which a cocktail‐based inhibitory DDI experiment was performed. Plasma samples and liver tissues from mice were collected for determination of gemfibrozil, gem‐glu concentration and cytochrome p450 enzyme (P450) induction analysis. In human, the molar ratio of gem‐glu/gemfibrozil was 15% and 10% at the trough concentration and the concentration at 1.5 h after the 6th dose. In contrast, this molar ratio at steady state in mice was 91%, demonstrating a 6‐ to 9‐fold difference compared with that in human. Interestingly, a net induction of P450 activity and in vivo inductive DDI potential in mice was revealed. The P450 activity was not inhibited although the gem‐glu concentration was high. These data suggested species difference of relative gem‐glu exposure between human and mice, as well as a net inductive DDI potential of gemfibrozil in mouse model.
Sizing of patent ductus arteriosus in adults for transcatheter closure using the balloon pull‐through technique
Authors: Shafi Nabil A. , Singh Gagan D. , Smith Thomas W. , Rogers Jason H. 
Published: September 2017

AbstractObjectivesTo describe a novel balloon sizing technique used during adult transcatheter patent ductus arteriosus (PDA) closure. In addition, to determine the clinical and procedural outcomes in six patients who underwent PDA balloon sizing with subsequent deployment of a PDA occluder device.BackgroundTranscatheter PDA closure in adults has excellent safety and procedural outcomes. However, PDA sizing in adults can be challenging due to variable defect size, high flow state, or anatomical complexity. We describe a series of six cases where the balloon‐ pull through technique was successfully performed for PDA sizing prior to transcatheter closure.MethodsConsecutive adult patients undergoing adult PDA closure at our institution were studied retrospectively. A partially inflated sizing balloon was pulled through the defect from the aorta into the pulmonary artery and the balloon waist diameter was measured. Procedural success and clinical outcomes were obtained.ResultsSix adult patients underwent successful balloon pull‐through technique for PDA sizing during transcatheter PDA closure, since conventional angiography often gave suboptimal opacification of the defect. All PDAs were treated with closure devices based on balloon PDA sizing with complete closure and no complications. In three patients that underwent preprocedure computed tomography, the balloon size matched the CT derived measurements.ConclusionThe balloon pull‐through technique for PDA sizing is a safe and accurate sizing modality in adults undergoing transcatheter PDA closure.
Propensity score matched all comers population treated with ultra‐thin strut bare metal and sirolimus‐probucol coated drug‐eluting stents of identical stent architecture
Authors: Krackhardt Florian , Rosli Mohd Ali , Leschke Matthias , Schneider André , Sperling Christian , Heang Tay Mok , Pons Maxime , Sousa Pedro Jerónimo , Kherad Behrouz , Waliszewski Matthias 
Published: September 2017

AbstractObjectiveThe objective of this study was to compare the safety and efficacy of a polymer‐free sirolimus coated, ultrathin strut drug eluting stent (PF‐SES) to its uncoated bare‐metal stent (BMS) platform of identical stent architecture.BackgroundRecently published randomized trials comparing BMS to DES with a focus on shortened dual‐antiplatelet therapy reported incidences of stent thrombosis (ST) and bleeding complications (LEADERS FREE) in favor of drug eluting stents (DES).MethodsData of previously published large‐sale, international, single‐armed, multicenter, observational studies of ultra‐thin PF‐SES, and BMS were propensity score (PS) matched for selected lesion morphological and cardiovascular risk factors to compare target lesion revascularization (TLR), myocardial infarction, cardiac death, major adverse cardiac events (MACE), bleeding complications and ST rates. Primary endpoint in both studies was TLR at 9 months.ResultsAt 9 months the rates of TLR was significantly lower in the PF‐SES group as compared with patients treated with the BMS analogue of identical stent design (1.4% vs. 4.6%, P = 0.005). Likewise the 9‐month MACE rates were lower in the PF‐SES group (3.2% vs. 8.7%, P = 0.001) whereas there were no differences in the accumulated ST rates (0.5% vs. 1.5%, P = 0.109). Overall accumulated bleeding incidences (BARC 1–5) were not significantly different between PF‐SES and BMS patients (1.8% vs. 2.7%, p = 0.388).ConclusionsPF‐SES are superior over analogue BMS of identical stent architecture in daily clinical routine with lower rates of TLR and MACE in a PS‐matched, unselected patient population without differences in accumulated ST rates and bleeding frequencies given the currently favored postprocedural comedication (ClinicalTrials.gov Identifier NCT02629575).
Intracoronary snaring of the retrograde guidewire: How to overcome extreme takeoff angles in chronic total occlusion percutaneous coronary intervention
Authors: Azzalini Lorenzo , Candilio Luciano , Carlino Mauro , Colombo Antonio 
Published: September 2017

AbstractExtreme angulation of coronary artery takeoff represents a challenge for wiring and device advancement in percutaneous coronary intervention (PCI). This anatomic feature is particularly adverse in cases of chronic total occlusion (CTO) of the ostial‐proximal segment of the target vessel. In this setting, the retrograde approach can help getting access to the occlusion. However, difficulties might arise at the critical step of wire externalization, due to the need to overcome the extreme ostial angle.Here, we describe a case of successful CTO PCI of the proximal circumflex artery, which presented an extreme angle at its takeoff. Due to inability to perform antegrade wiring of the occlusion, the retrograde approach was undertaken via epicardial collaterals from the right coronary artery. Since conventional attempts at re‐entering the antegrade guiding catheter failed due to the aforementioned extreme angle, the retrograde wire was snared in the mid left anterior descending artery, and externalization was performed. This case demonstrates the usefulness of coronary snares in the CTO operator's toolkit and shows how such devices can be used to safely and successfully complete challenging retrograde procedures.
Left ventricular perforation after Impella® placement in a patient with cardiogenic shock
Authors: Peritz David C. , Linstroth Lee , Selzman Craig H. , Gilbert Edward M. 
Published: September 2017

AbstractMechanical cardiovascular support devices are now widely used both in the setting of cardiogenic shock as well as during high risk cardiac catheterization procedures. We report a case of a young female patient who presented with presumed myocarditis and rapidly deteriorating decompensated heart failure requiring the implantation of an Impella Circulatory Support System. Upon transfer to our facility it was discovered that during transport, the Impella device had migrated through the left ventricle. She was emergently taken to the operating room where the Impella was surgically removed and biventricular support devices were placed. The patient eventually expired after weeks of treatment in the intensive care unit. We believe this is the first recorded case of an Impella device perforating the left ventricle. Particularly in cases of newly discovered pericardial effusion, change in waveform on the Impella controller placement signal or rapid decompensation, physicians should consider this rare but potentially catastrophic complication associated with mechanical left ventricular support devices.
Medullary nephrocalcinosis in idiopathic hypercalciuria
Authors: Koratala Abhilash , Bhatti Vikrampal 
Published: September 2017

Key Clinical MessageIdiopathic hypercalciuria is a metabolic abnormality characterized by excessive calcium excretion in the urine with normal serum calcium levels and is a common risk factor for formation of kidney stones and/or nephrocalcinosis. These patients benefit from a normal‐calcium, reduced‐animal protein, and low‐salt diet, along with a thiazide diuretic.
Room Temperature Decarboxylative and Oxidative [2+2+2] Annulation of Benzoic Acids with Alkynes Catalyzed by an Electron‐Deficient Rhodium(III) Complex
Authors: Honjo Yusaku , Shibata Yu , Kudo Eiji , Namba Tomoya , Masutomi Koji , Tanaka Ken 
Published: September 2017

AbstractIt has been established that an electron‐deficient (η5‐cyclopentadienyl)rhodium(III) [CpERhIII] complex is capable of catalyzing the decarboxylative and oxidative [2+2+2] annulation of benzoic acids with alkynes to produce substituted naphthalenes at room temperature. The appropriate choice of the additive and the solvent is crucial for this transformation. This catalyst system allowed use of oxygen as a terminal oxidant and broadened the substrate scope including both aromatic and aliphatic alkynes. In this catalysis, the electron deficient nature of the CpERhIII catalyst would cause the strong rhodium‐π interaction, which accelerates the decarboxylation as well as the C−H bond cleavage.
Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use
Authors: Pergam Steven A. , Woodfield Maresa C. , Lee Christine M. , Cheng Guang‐Shing , Baker Kelsey K. , Marquis Sara R. , Fann Jesse R. 
Published: September 2017

BACKGROUNDCannabis is purported to alleviate symptoms related to cancer treatment, although the patterns of use among cancer patients are not well known. This study was designed to determine the prevalence and methods of use among cancer patients, the perceived benefits, and the sources of information in a state with legalized cannabis.METHODSA cross‐sectional, anonymous survey of adult cancer patients was performed at a National Cancer Institute–designated cancer center in Washington State. Random urine samples for tetrahydrocannabinol provided survey validation.RESULTSNine hundred twenty‐six of 2737 eligible patients (34%) completed the survey, and the median age was 58 years (interquartile range [IQR], 46‐66 years). Most had a strong interest in learning about cannabis during treatment (6 on a 1‐10 scale; IQR, 3‐10) and wanted information from cancer providers (677 of 911 [74%]). Previous use was common (607 of 926 [66%]); 24% (222 of 926) used cannabis in the last year, and 21% (192 of 926) used cannabis in the last month. Random urine samples found similar percentages of users who reported weekly use (27 of 193 [14%] vs 164 of 926 [18%]). Active users inhaled (153 of 220 [70%]) or consumed edibles (154 of 220 [70%]); 89 (40%) used both modalities. Cannabis was used primarily for physical (165 of 219 [75%]) and neuropsychiatric symptoms (139 of 219 [63%]). Legalization significantly increased the likelihood of use in more than half of the respondents.CONCLUSIONSThis study of cancer patients in a state with legalized cannabis found high rates of active use across broad subgroups, and legalization was reported to be important in patients' decision to use. Cancer patients desire but are not receiving information about cannabis use during their treatment from oncology providers. Cancer 2017;123:4488‐97. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
A Bisamide Ruthenium Polypyridyl Complex as a Robust and Efficient Photosensitizer for Hydrogen Production
Authors: Schott Olivier , Pal Amlan K. , Chartrand Daniel , Hanan Garry S. 
Published: September 2017

AbstractA photosensitizer based on a ruthenium complex of a bisamide‐polypyridyl ligand gives rise to a large improvement in photocatalytic stability, rate of activity, and efficiency in photocatalytic H2 production compared to [Ru(bpy)3]2+ (bpy=2,2′‐bpyridine). The bisamide ruthenium polypyridyl complex combined with a cobaltoxime‐based photocatalyst was found to be highly efficient under blue‐light (turnover number (TON)=7800) and green‐light irradiation (TON=7200) whereas [Ru(bpy)3]2+ was significantly less effective with a TON of 2600 and 1100, respectively. The greatest improvement was under red‐light‐emitting diodes, with bisamide ruthenium polypyridyl complex and cobaltoxime exhibiting a TON of 4200 compared to [Ru(bpy)3]2+ and cobaltoxime at a TON of only 71.
Early adolescent stress‐induced changes in prefrontal cortex miRNA‐135a and hippocampal miRNA‐16 in male rats
Authors: Liu Yuan , Liu Dexiang , Xu Jingjing , Jiang Hong , Pan Fang 
Published: September 2017

AbstractEarly‐life stress increases susceptibility to post‐traumatic stress disorders (PTSD), in which the dysfunction of 5‐hydroxytryptamine plays an important role. miRNA‐135a in the prefrontal cortex (PFC) and miRNA‐16 in the hippocampus (HIP) are closely related to the 5‐HT neurotransmitter system. Here, we investigated behavior, miRNA‐135a in the PFC, miRNA‐16 in the HIP, and 5‐HT1AR expression in both brain regions in adolescent and adult rats that were exposed to inescapable stress during their adolescence. Paroxetine hydrochloride and corticotropin‐releasing factor antagonist (CP‐154,526) were used as intervening measures. Our study demonstrated that early adolescent stress induced anxiety‐like behaviors and spatial memory damage, a reduction in miRNA‐135a expression was associated with increased 5‐HT1AR expression in PFC, and increased miRNA‐16 expression in the HIP of stressed rats. Drug treatments alleviated behaviors and reversed the miRNA‐135a, miRNA‐16, and 5‐HT1AR expression in stressed rats.
Using species traits to predict detectability of animals on aerial surveys
Authors: Schlossberg S. , Chase M. J. , Griffin C. R. 
Published: September 2017

AbstractIn animal surveys, detectability can vary widely across species. We hypothesized that detectability of animals should be a function of species traits such as mass, color, and mean herd size. We also hypothesized that models of detectability based on species traits can be used to predict detectability for new species not in the original data set, leading to substantial benefits for ecology and conservation. We tested these hypotheses with double‐observer aerial surveys of 10 mammal species in northern Botswana. We combined all 10 species and modeled their detectability with species traits (mass, mean herd size, color) as predictors while controlling for observer effects, vegetation, and herd size. We found support for effects of mass and an interaction between herd size and mean herd size on detectability. This model accurately predicted the ratio of herds detected by two observers vs. one observer for 8 of 10 species. To test whether a model based on species traits could be applied to a new species, we serially deleted each species from the data set, fit a trait‐based model to the remaining nine species, and used this model to predict detectability for the deleted species. The model was able to reproduce the species‐trait model for seven species and accurately predicted the ratio of detections by one or two observers for a different set of seven species; the model was successful by both measures for five species. To our knowledge, this represents the first time that a mechanistic model for detectability of animals has been used to predict detectability for new species. Prediction failed for species with extreme values of traits, suggesting that predicting detectability is not possible near or beyond the boundaries of one's data set. The approach taken in this paper can potentially be used with a variety of taxa and may provide new opportunities to apply detectability corrections where they have not been possible before.
NK cells produce high levels of IL‐10 early after allogeneic stem cell transplantation and suppress development of acute GVHD
Authors: Chan Yuen Ling Tracey , Zuo Jianmin , Inman Charlotte , Croft Wayne , Begum Jusnara , Croudace Joanne , Kinsella Francesca , Maggs Luke , Nagra Sandeep , Nunnick Jane , Abbotts Ben , Craddock Charles , Malladi Ram , Moss Paul 
Published: September 2017

AbstractNatural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo‐SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell‐depleted allo‐SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK‐14) were donor‐derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue. Spontaneous production of the immunoregulatory cytokine IL‐10 was observed in over 70% of cells and transcription of cytokines and growth factors was augmented. NK‐14 cell number was inversely correlated with the incidence of grade II‐IV acute graft versus host disease (GVHD). These findings reveal that robust reconstitution of immunoregulatory NK cells by day 14 after allo‐SCT is an important determinant of the clinical outcome, suggesting that NK cells may suppress the development of the T cell‐mediated alloreactive immune response through production of IL‐10.
Iron(III)‐mediated Electrochemical Detection of Levofloxacin in Complex Biological Samples
Authors: Lotfi Zadeh Zhad Hamid R. , Lai Rebecca Y. 
Published: September 2017

AbstractWe report the design of an electrochemical sensor capable of detecting levofloxacin (LEVX) in complex biological samples. This detection strategy is simple, fast, and does not require sample pretreatment or electrode modification. Unlike previously developed electrochemical LEVX sensors that require direct oxidation of LEVX, the sensing mechanism is based on the complexation reactions between LEVX and iron(III), resulting in a concentration‐dependent decrease in the iron(III) reduction peak current and a shift in the peak potential. These changes are presumably attributed to the decrease in the concentration of uncomplexed Fe(III) in the solution. The concentration‐dependent change in both the current and potential can be used for quantification of LEVX in various samples, including 50 % synthetic urine and 25 % synthetic human saliva. The limit of detection was estimated to be in the range of 1.5 to 2.3 μM, concentrations that are much lower than the concentration of LEVX found in urine and saliva samples of patients administered this drug for conditions such as urinary tract infection. With further optimization, this sensing strategy could find applications in clinical pharmacokinetic studies.