bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of gas dynamics and dust in the evolved filament G82.65-02.00
Authors: Saajasto M. , Juvela M. , Dobashi K. , Shimoikura T. , Ristorcelli I. , Montillaud J. , Marshall D. J. , Malinen J. , Pelkonen V.-M. , Fehér O. , Rivera-Ingraham A. , Toth L. V. , Montier L. , Bernard J.-Ph. , Onishi T. 
Published: July 2017

Context. The combination of line and continuum observations can provide vital insight into the formation and fragmentation of filaments and the initial conditions for star formation. We have carried out line observations to map the kinematics of an evolved, actively star forming filament G82.65-2.00. The filament was first identified from the Planck data as a region of particularly cold dust emission and was mapped at 100–500 μm as a part of the Herschel key program Galactic Cold Cores. The Herschel observations cover the central part of the filament, corresponding to a filament length of ~ 12 pc at the assumed distance of 620 pc.
Aims. CO observations show that the filament has an intriguing velocity field with several velocity components around the filament. In this paper, we study the velocity structure in detail, to quantify possible mass accretion rate onto the filament, and study the masses of the cold cores located in the filament.
Methods. We have carried out line observations of several molecules, including CO isotopologues, HCO+, HCN, and CS with the Osaka 1.85 m telescope and the Nobeyama 45 m telescope. The spectral line data are used to derive velocity and column density information.
Results. The observations reveal several velocity components in the field, with strongest line emission concentrated to velocity range ~[3,5] km s-1. The column density of molecular hydrogen along the filament varies from 1.0 to 2.3 × 1022cm2. We have examined six cold clumps from the central part of the filament. The clumps have masses in the range 10−20M⊙ (~ 70 M⊙ in total) and are close to or above the virial mass. Furthermore, the main filament is heavily fragmented and most of the substructures have a mass lower than or close to the virial mass, suggesting that the filament is dispersing as a whole. Position-velocity maps of 12CO and 13CO lines indicate that at least one of the striations is kinematically connected to two of the clumps, potentially indicating mass accretion from the striation onto the main filament. We tentatively estimate the accretion rate to be Ṁ = 2.23 × 10-6M⊙/ yr.
Conclusions. Our line observations have revealed two or possibly three velocity components connected to the filament G82.65-2.00 and putative signs of mass accretion onto the filament. The line observations combined with Herschel and WISE maps suggest a possible collision between two cloud components.
Risk Factors for Premature Death in Diabetes Patients who Undergo Amputations below Ankle Level
Authors: Wilbek Therese , Jansen Rasmus , Jørgensen Bo , Svendsen Ole 
Published: July 2017

Abstract
Aim To identify risk factors for early death in diabetes patients who undergo amputations below the ankle.
Methods A retrospective study, where all hospital records of all diabetes patients who had undergone minimum one amputation below the ankle at the CWHC Bispebjerg Hospital, Denmark, in the period 1996–2013, were examined. The amputations were mainly trans-metatarsal amputations and partial amputations of toes. The participants were found via ICD10-codes. The included patients were followed from their first contact to the last registered contact. The statistical analysis in this article is performed on patients with a of minimum 5-year follow-up.
Results The 5 year mortality was 42% for patients with type 2 diabetes, and 29% for patients with type 1 diabetes. For patients with type 2 diabetes, multivariable analysis showed that high age, peripheral arterial insufficiency and short time from first admission to amputation were independently statistically significantly associated with increased 5-years mortality. Use of statins was associated with decreased mortality. 35% died as a result of their diabetes, mostly due to cardiovascular causes.
Conclusion Short time from first admission to amputation is a risk factor for early death. Arterial insufficiency and high age is also associated with increased mortality, whereas use of statin is associated with decreased mortality, in patients with type 2 diabetes.
Oberkiefermalignome – Ergebnisse einer monozentrischen Studie über 45 Jahre
Authors: Böhm Michaela , Kappler Matthias , Dauter Kevin , Reich Waldemar , Eckert Alexander 
Published: July 2017

Zusammenfassung
Hintergrund Malignome der Oberkieferregion sind vergleichsweise selten. Ziel der monozentrischen retrospektiven Studie war, Aussagen zur Histologie, zum Grading und zum Staging dieser Tumoren treffen zu können.
Material und Methoden Seit 1969 wurden insgesamt 199 Patienten retrospektiv untersucht, bei denen aufgrund einer malignen Neubildung des Oberkiefers eine chirurgische bzw. kombiniert chirurgisch-radiotherapeutische Behandlung erfolgte. Kernstück der Analyse waren neben der histologischen Einteilung aller Malignome beim Plattenepithelkarzinom die TNM-Klassifikation, die histomorphologische Differenzierung (Grading) wie auch die Überlebenswahrscheinlichkeit nach Kaplan-Meier.
Ergebnisse Es zeigt sich, dass Plattenepithelkarzinome mit etwa 60% die häufigsten Malignome des Oberkiefers waren. Ihre 5-Jahres-Überlebenswahrscheinllichkeit lag mit mehr als 60% deutlich über den Werten anderer Mundhöhlenkarzinome, obgleich etwa ⅔ der Tumoren im fortgeschrittenen T4-Stadium waren. Die Plattenepithelkarzinome waren zu etwa ⅔ der Fälle gut differenziert, G2- und G3-Tumoren fanden sich deutlich seltener.
Schlussfolgerung Die Rezidivhäufigkeit erhöht sich mit steigender Entdifferenzierung im Gegensatz zur Überlebenswahrscheinlichkeit. Insgesamt lassen Oberkieferkarzinome bei adäquater chirurgischer und radiologischer Therapie gute ästhetische und befriedigende funktionelle Resultate erwarten.
The Impact of Coffee on Health
Authors: Nieber Karen 
Published: July 2017

AbstractCoffee is one of the most popular and widely consumed beverages worldwide due to its stimulating effects on the central nervous system as well as its taste and aroma. Coffee is a complex mixture of more than 800 volatile compounds whereas caffeine and chlorogenic acids are the most common compounds. During the last years, coffee has progressively moved to a less negative position on health due to its better-known pharmacology. Caffeine, e.g., in a cup of coffee, appears to exert most of its effects through an antagonism of the adenosine receptors. Novel approaches in epidemiological studies and experimental researches suggest that coffee consumption may help to prevent several chronic diseases, including type 2 diabetes mellitus and liver disease. Most prospective cohort studies have not found coffee consumption to be associated with a significantly increased cardiovascular disease risk. There is also evidence that decaffeinated coffee may, in some respect, have similar benefits as regular coffee, indicating that besides caffeine other components contribute to the health protecting effects. For adults consuming moderate amounts of coffee (3 – 4 cups/d providing 300 – 400 mg/d of caffeine), there is little evidence of health risks and some evidence of health benefits. This review provides up-to-date information about coffee on health. Topics addressed include the cardiovascular system, liver diseases, and diabetes as well as gastrointestinal disorders.
Ordinary religious experience, learning and adaptation: a call for interdisciplinary inquiry
Authors: F. Barrett Nathaniel 
Published: July 2017

AbstractWithin disciplines of religious studies, discussions of religious experience tend to revolve around the most rare and extraordinary cases, while neglecting much more common varieties of “ordinary religious experience”—that is, experiences of regular practitioners in the midst of normal religious activities such as worship or prayer. This comment will, first, call attention to this essential aspect of religious life, and, second, will suggest ways in which it can be made more accessible to investigation. This article suggests that researchers focus on the variability of engagement in religious practice and the processes of learning and adaptation by which regular practitioners enhance their experience of religious practice. It also suggests that ethnographic studies be extended by carefully selected theories of perception and cognition that address the role of material conditions in ordinary religious experience.
The “competent child” in times of crisis: a synthesis of Foucauldian with critical discourse analysis in Greek pre-school curricula
Authors: Pechtelidis Yannis , G. Stamou Anastasia 
Published: July 2017

AbstractLate modern children usually have school experiences from a very young age. Therefore, official educational discourses have the potential to shape their everyday life and subjectivity. The objective of this article is to explore the forms of knowledge that were produced around early childhood and schooling by the two most recent curricula of the Greek pre-school educational system in an era of crisis. In this framework, a discourse analytical approach is proposed which combines Foucauldian with critical discourse analysis. From the analysis, it appears that both curricula actively engage in the discursive struggle for hegemony in society, producing a specific understanding of childhood and schooling. In particular, according to the analysis, both curricula echo a neo-liberal discourse, which could exert a specific ideological power upon young children’s subjectivity. However, it was found that the most recent curriculum is even more focused on the neo-liberal ideological project. This conceptual shift could be understood in the current context of the hegemony of the neo-liberal ideology in the social field. Moreover, it was found that both curricula contain several child-oriented elements, crafting the image of “the competent child”. However, these elements could probably function as a subtle instrument for further achieving the aims of the neo-liberal hegemonic discourse for antagonism and entrepreneurship. As children do not passively receive the content addressed to them, future research on the relationship between representations and subjective experiences is deemed necessary.
Brain regions and functional interactions supporting early word recognition in the face of input variability
Authors: Benavides-Varela Silvia , Siugzdaite Roma , Gómez David Maximiliano , Macagno Francesco , Cattarossi Luigi , Mehler Jacques 
Published: July 2017

SignificanceSince birth, infants begin to learn a myriad of sounds. Yet our knowledge of their abilities to remember specific sounds is primarily based on habituation studies that presented them with massive repetitions of single sounds. The present work opens vistas on the study of language acquisition and memory development by suggesting that the presence of various sounds during encoding does not impair recognition in newborns. Results also indicate that a coordinated interplay between temporal and frontal regions of the brain supports newborns’ ability to memorize specific words in this—previously thought—disruptive context.
Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood
Authors: McDade Thomas W. , Ryan Calen , Jones Meaghan J. , MacIsaac Julia L. , Morin Alexander M. , Meyer Jess M. , Borja Judith B. , Miller Gregory E. , Kobor Michael S. , Kuzawa Christopher W. 
Published: July 2017

SignificanceEnvironments in infancy and childhood influence levels of inflammation in adulthood—an important risk factor for multiple diseases of aging—but the underlying biological mechanisms remain uncertain. Using data from a unique cohort study in the Philippines with a lifetime of information on each participant, we provide evidence that nutritional, microbial, and psychosocial exposures in infancy and childhood predict adult levels of DNA methylation—biochemical marks on the genome that affect gene expression—in genes that regulate inflammation. We also show that DNA methylation in these genes relates to levels of inflammatory biomarkers implicated in cardiovascular and other diseases. These results suggest that epigenetic mechanisms may partially explain how early environments have enduring effects on inflammation and inflammation-related diseases.
Cytokinin induces genome-wide binding of the type-B response regulator ARR10 to regulate growth and development inArabidopsis
Authors: Zubo Yan O. , Blakley Ivory Clabaugh , Yamburenko Maria V. , Worthen Jennifer M. , Street Ian H. , Franco-Zorrilla José M. , Zhang Wenjing , Hill Kristine , Raines Tracy , Solano Roberto , Kieber Joseph J. , Loraine Ann E. , Schaller G. Eric 
Published: July 2017

SignificanceCytokinins, like other plant hormones, affect a diverse array of plant growth and development processes and responses to the environment. How a signaling molecule mediates such a diverse array of outputs and how these response pathways are integrated with other inputs remain fundamental questions in plant biology. An integrated set of approaches was used to define the targets of the type-B response regulators, a key set of transcription factors that control cytokinin-dependent gene expression. Results shed light on the physiological role of the type-B ARRs in regulating the cytokinin response, mechanism of type-B ARR activation, and basis by which cytokinin regulates diverse aspects of growth and development as well as responses to biotic and abiotic factors.
Network analysis reveals strongly localized impacts of El Niño
Authors: Fan Jingfang , Meng Jun , Ashkenazy Yosef , Havlin Shlomo , Schellnhuber Hans Joachim 
Published: July 2017

Significance
El Niño, one of the strongest climatic phenomena on interannual time scales, affects the climate system and is associated with natural disasters and serious social conflicts. Here, using network theory, we construct a directed and weighted climate network to study the global impacts of El Niño and La Niña. The constructed climate network enables the identification of the regions that are most drastically affected by specific El Niño/La Niña events. Our analysis indicates that the effect of the El Niño basin on worldwide regions is more localized and stronger during El Niño events compared with normal times.
Clusters of calcium release channels harness the Ising phase transition to confine their elementary intracellular signals
Authors: Maltsev Anna V. , Maltsev Victor A. , Stern Michael D. 
Published: July 2017

Significance
Living organisms are built on a hierarchy of levels, starting from macromolecules and clusters of molecules, to organelles, cells, and tissues, with interacting organs finally forming the entire organism. At the lowest of these levels life depends on individual molecules synchronizing their states to generate robust intracellular signals over the thermal noise. Here we approach the problem via statistical mechanics to describe quantitatively and deterministically this first emerging level of life. We discover that the synchronization that corresponds to termination of local Ca signals generated by clusters of Ca release channels is governed by the same equations as the phase transition associated with the reversal of magnetic field in a classical Ising ferromagnet.
Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation
Authors: Yuan Ye , Spate Lee D. , Redel Bethany K. , Tian Yuchen , Zhou Jie , Prather Randall S. , Roberts R. Michael 
Published: July 2017

Significance
The efficiency of production of genetically altered piglets for agricultural and biomedical purposes is very low, in large part because of the poor quality of the in vitro-matured oocytes used to initiate the process. Here, we describe a chemically defined culture medium that enhances porcine oocyte maturation and subsequent embryo development to the blastocyst stage, and increases the number of offspring born after embryo transfer, thereby effectively quadrupling the efficiency of piglet production. This research also provides some insights into the physiological events that lead to oocyte competence and how the efficacy of oocyte in vitro maturation might be improved in other species.
Origin of long lifetime of band-edge charge carriers in organic–inorganic lead iodide perovskites
Authors: Chen Tianran , Chen Wei-Liang , Foley Benjamin J. , Lee Jooseop , Ruff Jacob P. C. , Ko J. Y. Peter , Brown Craig M. , Harriger Leland W. , Zhang Depei , Park Changwon , Yoon Mina , Chang Yu-Ming , Choi Joshua J. , Lee Seung-Hun 
Published: July 2017

Significance
Hybrid organic–inorganic perovskites (HOIPs) are among the most promising materials for next-generation solar cells that combine high efficiency and low cost. The record efficiency of HOIP-based solar cells has reached above 22%, which is comparable to that of silicon solar cells. HOIP solar cells can be manufactured using simple solution processing methods that can be drastically cheaper than the current commercial solar cell technologies. Despite the progress so far, the microscopic mechanism for the high solar cell efficiency in HOIPs is yet to be understood. Our study shows that rotation of organic molecules in HOIPs extends the lifetime of photoexcited charge carriers, leading to the high efficiency. This insight can guide the progress toward improved solar cell performance.
Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy
Authors: Liao Li-Xi , Song Xiao-Min , Wang Li-Chao , Lv Hai-Ning , Chen Jin-Feng , Liu Dan , Fu Ge , Zhao Ming-Bo , Jiang Yong , Zeng Ke-Wu , Tu Peng-Fei 
Published: July 2017

Significance
Inosine monophosphate dehydrogenase (IMPDH) is an attractive target for immunosuppressive agents. Currently, small-molecule inhibitors do not show good selectivity for different IMPDH isoforms (IMPDH1 and IMPDH2), resulting in some adverse effects, which limit their use. Here, we identified Cys140 as an isoform-selective druggable binding site for IMPDH2 inhibition but not for IMPDH1. We found small-molecule sappanone A directly covalently targets Cys140 in IMPDH2 to block its activity, resulting in neuroinflammatory inhibition with less side effects than pan-IMPDH inhibitor. In summary, our findings reveal Cys140 is a druggable binding site for selectively inhibiting IMPDH2 for neuroinflammatory diseases with less unfavorable tolerability profile.
A method for mitigating the problem of borrowing in syntactic reconstruction
Authors: Daniels Don 
Published: July 2017

AbstractMost scholars agree that grammatical borrowing is a serious obstacle to syntactic reconstruction, but to date there have been few proposed solutions to this methodological conundrum. In this paper I propose a method, couched in a constructional view of language, for mitigating the problem of borrowing in syntactic reconstruction. The method begins with the reconstruction of partially schematic constructions, whose phonological material can be tested for cognacy. Fully schematic reconstructions are then achieved via generalizations made over sets of reconstructed constructions. I exemplify the effectiveness of this method by applying it to two pieces of grammar from the Sogeram languages of Papua New Guinea: clause chain nominalization and the desiderative construction. The method allows the reconstruction of the former, but identifies the latter as a likely grammatical borrowing and therefore not reconstructable to Proto-Sogeram.
Late cochlear implant in a prelingually hearing impaired subject
Authors: Gheller F. , Ghiselli S. , Montino S. , Ermani M. , Trevisi P. 
Published: July 2017

Objectives:
The aim of this study was to evaluate electrophysiological and audiological findings in a prelingually late implanted patient, in two consecutive follow-ups: 3 months after cochlear implant (CI) activation and 1 year later.

Methods:
As an electrophysiological evaluation, the event-related potentials (ERPs) N100, N200-P300 were used. The P300 wave is an objective measure of the central auditory function. It reflects the cortical activity involved during attention, discrimination, memory, integration and decision-making skills and it is a measure of speech discrimination and linguistic recognition. Pure tone audiometry, speech perception tests and electrophysiological examination were performed at 3 and 15 months post-CI activation.

Result and Discussion:
The N100 and N200 latencies were very similar in both follow-ups, whereas P300 latency decreased significantly 15 months postactivation, reaching a value close to normality. This finding was related to an increase in audiometric and speech performances.

Conclusion:
A significant improvment in electrophysiological, audiometric and speech performances was observed during the second follow-up, underlining the great importance of the duration of device use, in spite of a late implant surgery. These simultaneous improvements can be related to a general increase of superior cognitive functions.
How Competitive Are Crop Markets in Sub‐Saharan Africa?
Authors: Dillon Brian , Dambro Chelsey 
Published: July 2017

AbstractDuring the structural adjustment era of the 1980s and 1990s, governments across sub‐Saharan Africa generally withdrew from crop markets to encourage entry by private traders and foster competition. Since that time, the degree of competition in crop markets has been a central concern of policymakers, donors, and researchers. We review the evidence on that topic by first developing a conceptual framework to guide our analysis, then discussing the findings from four categories of literature. We have two main findings. First, there is a paucity of empirical evidence on this question, which hinders our ability to draw strong conclusions. Second, that point notwithstanding, the evidence that does exist is broadly supportive of the notion that crop markets are competitive. The dominant themes in the literature are that trading profits are highly variable, trader entry and exit rates are high, and price co‐movements between markets suggest relatively efficient levels of competitive arbitrage. It is possible that the high costs of entry foster non‐competitive conditions at the level of large‐scale, long‐distance subnational trade, but we find no positive evidence to that effect, only the satisfaction of certain necessary conditions.
Irys Extract
Authors: Arielly Rani , Ebenstein Yuval 
Published: July 2017

Abstract

Summary
Irys Extract is a software tool for generating genomic information from data collected by the BioNano Genomics Irys platform. The tool allows the user easy access to the raw data in the form of cropped images and genetically aligned intensity profiles. The latter are also made compatible with the BED format for using with popular genomic browsers such as the UCSC Genome Browser.

Availability and implementation
Irys Extract has been developed in Matlab R2015a, it was tested to work with IrysView 2.4.0.15879 and AutoDetect 2.1.4.9159, and it currently runs under Microsoft Windows operating systems (7-10). Irys Extract can be downloaded alongside its manual and a demo dataset at http://www.nanobiophotonix.com and https://sites.google.com/site/raniarielly/.

Supplementary information
Supplementary data are available at Bioinformatics online.