bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly accurate quantitative spectroscopy of massive stars in the Galaxy
Authors: Nieva María-Fernanda , Przybilla Norbert 
Published: July 2017

AbstractAchieving high accuracy and precision in stellar parameter and chemical composition determinations is challenging in massive star spectroscopy. On one hand, the target selection for an unbiased sample build-up is complicated by several types of peculiarities that can occur in individual objects. On the other hand, composite spectra are often not recognized as such even at medium-high spectral resolution and typical signal-to-noise ratios, despite multiplicity among massive stars is widespread. In particular, surveys that produce large amounts of automatically reduced data are prone to oversight of details that turn hazardous for the analysis with techniques that have been developed for a set of standard assumptions applicable to a spectrum of a single star. Much larger systematic errors than anticipated may therefore result because of the unrecognized true nature of the investigated objects, or much smaller sample sizes of objects for the analysis than initially planned, if recognized. More factors to be taken care of are the multiple steps from the choice of instrument over the details of the data reduction chain to the choice of modelling code, input data, analysis technique and the selection of the spectral lines to be analyzed. Only when avoiding all the possible pitfalls, a precise and accurate characterization of the stars in terms of fundamental parameters and chemical fingerprints can be achieved that form the basis for further investigations regarding e.g. stellar structure and evolution or the chemical evolution of the Galaxy. The scope of the present work is to provide the massive star and also other astrophysical communities with criteria to evaluate the quality of spectroscopic investigations of massive stars before interpreting them in a broader context. The discussion is guided by our experiences made in the course of over a decade of studies of massive star spectroscopy ranging from the simplest single objects to multiple systems.
Binary Population and Spectral Synthesis
Authors: Eldridge J. J. , Stanway E. R. , Xiao L. , McClelland L. A. S. , Bray J. C. , Taylor G. , Ng M. 
Published: July 2017

AbstractWe have recently released version 2.0 of the Binary Population and Spectral Synthesis (BPASS) population synthesis code. This is designed to construct the spectra and related properties of stellar populations built from ~200,000 detailed, individual stellar models of known age and metallicity. The output products enable a broad range of theoretical predictions for individual stars, binaries, resolved and unresolved stellar populations, supernovae and their progenitors, and compact remnant mergers. Here we summarise key applications that demonstrate that binary populations typically reproduce observations better than single star models.
The multiplicity of massive stars: a 2016 view
Authors: Sana Hugues 
Published: July 2017

AbstractMassive stars like company. Here, we provide a brief overview of progresses made over the last 5 years by a number of medium and large surveys. These results provide new insights on the observed and intrinsic multiplicity properties of main sequence massive stars and on the initial conditions for their future evolution. They also bring new interesting constraints on the outcome of the massive star formation process.
Clumping in stellar winds and interiors
Authors: Gräfener Götz 
Published: July 2017

AbstractThe uncertain clumping properties pose a major problem for the quantitative analysis and the modelling of hot star winds. New results suggest that also the outer envelopes of massive stars may be affected by clumping, with important consequences for their observable radii and ionising properties. In this talk I will discuss how clumping is incorporated in stellar interior and wind/atmosphere models, how current theoretical results compare with observations, and what we can learn from a combination of stellar interior models and winds.
High angular resolution radio and infrared view of optically dark supernovae in luminous infrared galaxies
Authors: Mattila Seppo , Kankare Erkki , Kool Erik , Romero-Cañizales Cristina , Ryder Stuart , Perez-Torres Miguel 
Published: July 2017

AbstractIn luminous and ultraluminous infrared galaxies (U/LIRGs), the infall of gas into the central regions strongly enhances the star formation rate (SFR), especially within the nuclear regions which have also large amounts of interstellar dust. Within these regions SFRs of several tens to hundreds of solar masses per year ought to give rise to core-collapse supernova (SN) rates up to 1-2 SNe every year per galaxy. However, the current SN surveys, almost exclusively being ground-based seeing-limited and working at optical wavelengths, have been blinded by the interstellar dust and contrast issues therein. Thus the properties and rates of SNe in the nuclear environments of the most prolific SN factories in the Universe have remained largely unexplored. Here, we present results from high angular resolution observations of nearby LIRGs at infrared and radio wavelengths much less affected by the effects of extinction and lack of resolution hampering the optical searches.
The evolution of red supergiants to supernovae
Authors: Beasor Emma R. , Davies Ben 
Published: July 2017

AbstractWith red supergiants (RSGs) predicted to end their lives as Type IIP core collapse supernova (CCSN), their behaviour before explosion needs to be fully understood. Mass loss rates govern RSG evolution towards SN and have strong implications on the appearance of the resulting explosion. To study how the mass-loss rates change with the evolution of the star, we have measured the amount of circumstellar material around 19 RSGs in a coeval cluster. Our study has shown that mass loss rates ramp up throughout the lifetime of an RSG, with more evolved stars having mass loss rates a factor of 40 higher than early stage RSGs. Interestingly, we have also found evidence for an increase in circumstellar extinction throughout the RSG lifetime, meaning the most evolved stars are most severely affected. We find that, were the most evolved RSGs in NGC2100 to go SN, this extra extinction would cause the progenitor’s initial mass to be underestimated by up to 9M⊙.
The VLT/X-shooter GRB afterglow legacy survey
Authors: Kaper Lex , Fynbo Johan P.U. , Pugliese Vanna , van Rest Daan 
Published: July 2017

AbstractThe Swift satellite allows us to use gamma-ray bursts (GRBs) to peer through the hearts of star forming galaxies through cosmic time. Our open collaboration, representing most of the active European researchers in this field, builds a public legacy sample of GRB X-shooter spectroscopy while Swift continues to fly. To date, our spectroscopy of more than 100 GRB afterglows covers a redshift range from 0.059 to about 8 (Tanvir et al. 2009, Nature 461, 1254), with more than 20 robust afterglow-based metallicity measurements (over a redshift range from 1.7 to 5.9). With afterglow spectroscopy (throughout the electromagnetic spectrum from X-rays to the sub-mm) we can hence characterize the properties of star-forming galaxies over cosmic history in terms of redshift, metallicity, molecular content, ISM temperature, UV-flux density, etc.. These observations provide key information on the final evolution of the most massive stars collapsing into black holes, with the potential of probing the epoch of the formation of the first (very massive) stars.VLT/X-shooter (Vernet et al. 2011, A&A 536, A105) is in many ways the ideal GRB follow-up instrument and indeed GRB follow-up was one of the primary science cases behind the instrument design and implementation. Due to the wide wavelength coverage of X-shooter, in the same observation one can detect molecular H2 absorption near the atmospheric cut-off and many strong emission lines from the host galaxy in the near-infrared (e.g., Friis et al. 2015, MNRAS 451, 167). For example, we have measured a metallicity of 0.1 Z⊙ for GRB 100219A at z = 4.67 (Thöne et al. 2013, MNRAS 428, 3590), 0.02 Z⊙ for GRB 111008A at z = 4.99 (Sparre et al. 2014, ApJ 785, 150) and 0.05 Z⊙ for GRB 130606A at z = 5.91 (Hartoog et al. 2015, A&A 580, 139). In the latter, the very high value of [Al/Fe]=2.40 ± 0.78 might be due to a proton capture process and may be a signature of a previous generation of massive (perhaps even the first) stars. Reconciling the abundance patterns of GRB absorbers, other types of absorbers (in particular QSO DLAs), and old stars in the Local Group is an important long-term goal of this program (see Sparre et al. 2014, ApJ 785, 150). Metallicities are also measured from host emission lines (Krühler et al. 2015, A&A 581, A125). GRB spectroscopy also allows us to determine the dust content of their environments, both through analysis of the depletion pattern and the measurement of the associated extinction (Japelj et al. 2015, A&A 451, 2050). This way one can quantify the dust-to-metals ratio and its evolution with redshift. The detection of GRBs at z > 6 shows that GRBs have become competitive as a tool to identifying galaxies at the highest redshifts and unsurpassed in providing detailed abundance information via absorption line spectroscopy.
II Zw 40 – 30 Doradus on Steroids
Authors: Leitherer Claus , Lee Janice C. , Levesque Emily M. 
Published: July 2017

AbstractWe obtained HST COS G140L spectra of the enigmatic nearby blue compact dwarf galaxy II Zw 40. The galaxy hosts a nuclear super star cluster embedded in a radio-bright nebula, similar to those observed in the related blue compact dwarfs NGC 5253 and Henize 2-10. The ultraviolet spectrum of II Zw 40 is exceptional in terms of the strength of He II 1640, O III] 1666 and C III] 1909. We determined reddening, age, and the cluster mass from the ultraviolet data. The super nebula and the ionizing cluster exceed the ionizing luminosity and stellar mass of the local benchmark 30 Doradus by an order of magnitude. Comparison with stellar evolution models accounting for rotation reveals serious short-comings: these models do not account for the presence of Wolf-Rayet-like stars at young ages observed in II Zw 40. Photoionization modeling is used to probe the origin of the nebular lines and determine gas phase abundances. C/O is solar, in agreement with the result of the stellar-wind modeling.
X-ray Emission from Massive Stars at the Core of Very Young Clusters
Authors: Schulz Norbert S. 
Published: July 2017

AbstractMost cores of very young stellar clusters contain one or more massive stars at various evolutionary stages. Observations of the Orion Nebula Cluster, Trumpler 37, NGC 2362, RCW38, NGC 3603 and many others provide the most comprehensive database to study stellar wind properties of these massive cluster stars in X-rays. In this presentation we review some of these observations and results and discuss them in the context of stellar winds and possible evolutionary implications. We argue that in very young clusters such as RCW38 and M17, shock heated remnants of a natal shell could serve as an alternate explanation to the colliding wind paradigm for the hot plasma components in the X-ray spectra.
WR 148 and the not so compact companion
Authors: Munoz Melissa , Moffat Anthony J. , Hill Grant M. , Shenar Tomer , Richardson Noel D. , Pablo Herbert , St-Louis Nicole , Ramiaramanantsoa Tahina 
Published: July 2017

AbstractThe objective is to determine the nature of the unseen companion of the single-lined spectroscopic binary, WR 148 (= WN7h+?). The absence of companion lines supports a compact companion (cc) scenario. The lack of hard X-rays favours a non-compact companion scenario. Is WR 148 a commonplace WR+OB binary or a rare WR+cc binary?
Freeform spectrometer enabling increased compactness
Authors: Reimers Jacob , Bauer Aaron , Thompson Kevin P , Rolland Jannick P 
Published: July 2017

AbstractWe present optical designs with freeform optics in the context of hyperspectral imaging. Results show designs that are 5 × more compact in volume than similar designs using conventional spherical or aspherical surfaces. We will show how combining the concepts of spatial and spectral-band broadening, which will be introduced in this paper, led to the improvement in compactness that is uniquely enabled by freeform optics.
Electromagnetic reprogrammable coding-metasurface holograms
Authors: Li Lianlin , Jun Cui Tie , Ji Wei , Liu Shuo , Ding Jun , Wan Xiang , Bo Li Yun , Jiang Menghua , Qiu Cheng-Wei , Zhang Shuang 
Published: July 2017

AbstractMetasurfaces have enabled a plethora of emerging functions within an ultrathin dimension, paving way towards flat and highly integrated photonic devices. Despite the rapid progress in this area, simultaneous realization of reconfigurability, high efficiency, and full control over the phase and amplitude of scattered light is posing a great challenge. Here, we try to tackle this challenge by introducing the concept of a reprogrammable hologram based on 1-bit coding metasurfaces. The state of each unit cell of the coding metasurface can be switched between ‘1’ and ‘0’ by electrically controlling the loaded diodes. Our proof-of-concept experiments show that multiple desired holographic images can be realized in real time with only a single coding metasurface. The proposed reprogrammable hologram may be a key in enabling future intelligent devices with reconfigurable and programmable functionalities that may lead to advances in a variety of applications such as microscopy, display, security, data storage, and information processing.
Broadband achromatic optical metasurface devices
Authors: Wang Shuming , Wu Pin Chieh , Su Vin-Cent , Lai Yi-Chieh , Hung Chu Cheng , Chen Jia-Wern , Lu Shen-Hung , Chen Ji , Xu Beibei , Kuan Chieh-Hsiung , Li Tao , Zhu Shining , Tsai Din Ping 
Published: July 2017

AbstractAmong various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chromatic aberration. Here we propose a design principle to realize achromatic metasurface devices which successfully eliminate the chromatic aberration over a continuous wavelength region from 1200 to 1680 nm for circularly-polarized incidences in a reflection scheme. For this proof-of-concept, we demonstrate broadband achromatic metalenses (with the efficiency on the order of ∼12%) which are capable of focusing light with arbitrary wavelength at the same focal plane. A broadband achromatic gradient metasurface is also implemented, which is able to deflect wide-band light by the same angle. Through this approach, various flat achromatic devices that were previously impossible can be realized, which will allow innovation in full-color detection and imaging.
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
Authors: Agnihotri Sameer , Suppiah Suganth , Tonge Peter D. , Jalali Shahrzad , Danesh Arnavaz , Bruce Jeffery P. , Mamatjan Yasin , Klironomos George , Gonen Lior , Au Karolyn , Mansouri Sheila , Karimi Sharin , Sahm Felix , von Deimling Andreas , Taylor Michael D. , Laperriere Normand J. , Pugh Trevor J. , Aldape Kenneth D. , Zadeh Gelareh 
Published: July 2017

AbstractCranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). We characterized 31 RIMs with exome/NF2 intronic sequencing, RNA sequencing and methylation profiling, and found NF2 gene rearrangements in 12/31 of RIMs, an observation previously unreported in sporadic meningioma (SM). Additionally, known recurrent mutations characteristic of SM, including AKT1, KLF4, TRAF7 and SMO, were not observed in RIMs. Combined losses of chromosomes 1p and 22q were common in RIMs (16/18 cases) and overall, chromosomal aberrations were more complex than that observed in SM. Patterns of DNA methylation profiling supported similar cell of origin between RIMs and SMs. The findings indicate that the mutational landscape of RIMs is distinct from SMs, and have significant therapeutic implications for survivors of childhood cranial radiation and the elucidation of the molecular pathogenesis of meningiomas.
Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1)
Authors: Li Zhijie , Fischer Michael , Satkunarajah Malathy , Zhou Dongxia , Withers Stephen G. , Rini James M. 
Published: July 2017

AbstractProteinO-glucosyltransferase 1/Rumi-mediated glucosylation of Notch epidermal growth factor-like (EGF-like) domains plays an important role in Notch signaling. ProteinO-glucosyltransferase 1 shows specificity for folded EGF-like domains, it can only glycosylate serine residues in the C1XSXPC2motif, and it possesses an uncommon dual donor substrate specificity. Using several EGF-like domains and donor substrate analogs, we have determined the structures of human ProteinO-glucosyltransferase 1 substrate/product complexes that provide mechanistic insight into the basis for these properties. Notably, we show that ProteinO-glucosyltransferase 1’s requirement for folded EGF-like domains also leads to its serine specificity and that two distinct local conformational states are likely responsible for its ability to transfer both glucose and xylose. We also show that ProteinO-glucosyltransferase 1 possesses the potential to xylosylate a much broader range of EGF-like domain substrates than was previously thought. Finally, we show that ProteinO-glucosyltransferase 1 has co-evolved with EGF-like domains of the type found in Notch.
Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
Authors: Choo Myeongjeong , Miyazaki Taisuke , Yamazaki Maya , Kawamura Meiko , Nakazawa Takanobu , Zhang Jianling , Tanimura Asami , Uesaka Naofumi , Watanabe Masahiko , Sakimura Kenji , Kano Masanobu 
Published: July 2017

AbstractElimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated in each PC dependent on postsynaptic activity in PC, but the underlying mechanisms are largely unknown. Here, we report that brain-derived neurotrophic factor (BDNF) from PC facilitates CF synapse elimination. By PC-specific deletion of BDNF combined with knockdown of BDNF receptors in CF, we show that BDNF acts retrogradely on TrkB in CFs, and facilitates elimination of CF synapses from PC somata during the third postnatal week. We also show that BDNF shares signaling pathway with metabotropic glutamate receptor 1, a key molecule that triggers a canonical pathway for CF synapse elimination. These results indicate that unlike other synapses, BDNF mediates punishment signal for synapse elimination in the developing cerebellum.
Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
Authors: Khan Faiz M. , Marquardt Stephan , Gupta Shailendra K. , Knoll Susanne , Schmitz Ulf , Spitschak Alf , Engelmann David , Vera Julio , Wolkenhauer Olaf , Pützer Brigitte M. 
Published: July 2017

AbstractCancer is a disease of subverted regulatory pathways. In this paper, we reconstruct the regulatory network around E2F, a family of transcription factors whose deregulation has been associated to cancer progression, chemoresistance, invasiveness, and metastasis. We integrate gene expression profiles of cancer cell lines from two E2F1-driven highly aggressive bladder and breast tumors, and use network analysis methods to identify the tumor type-specific core of the network. By combining logic-based network modeling, in vitro experimentation, and gene expression profiles from patient cohorts displaying tumor aggressiveness, we identify and experimentally validate distinctive, tumor type-specific signatures of receptor proteins associated to epithelial–mesenchymal transition in bladder and breast cancer. Our integrative network-based methodology, exemplified in the case of E2F1-induced aggressive tumors, has the potential to support the design of cohort- as well as tumor type-specific treatments and ultimately, to fight metastasis and therapy resistance.
Discovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning
Authors: Yang Yi , Chen Bo , Hower James , Schindler Michael , Winkler Christopher , Brandt Jessica , Di Giulio Richard , Ge Jianping , Liu Min , Fu Yuhao , Zhang Lijun , Chen Yuru , Priya Shashank , Hochella Michael F. 
Published: July 2017

AbstractCoal, as one of the most economic and abundant energy sources, remains the leading fuel for producing electricity worldwide. Yet, burning coal produces more global warming CO2 relative to all other fossil fuels, and it is a major contributor to atmospheric particulate matter known to have a deleterious respiratory and cardiovascular impact in humans, especially in China and India. Here we have discovered that burning coal also produces large quantities of otherwise rare Magnéli phases (Ti
x
O2x–1 with 4 ≤ x ≤ 9) from TiO2 minerals naturally present in coal. This provides a new tracer for tracking solid-state emissions worldwide from industrial coal-burning. In its first toxicity testing, we have also shown that nanoscale Magnéli phases have potential toxicity pathways that are not photoactive like TiO2 phases, but instead seem to be biologically active without photostimulation. In the future, these phases should be thoroughly tested for their toxicity in the human lung.
Risk stratification with Breast Cancer Index for late distant recurrence in patients with clinically low-risk (T1N0) estrogen receptor-positive breast cancer
Authors: Schroeder Brock , Zhang Yi , Stål Olle , Fornander Tommy , Brufsky Adam , Sgroi Dennis C. , Schnabel Catherine A. 
Published: July 2017

AbstractPatients with early-stage, hormone receptor–positive breast cancer with favorable clinicopathologic features are often not recommended for extended endocrine therapy. However, even patients with T1N0 disease remain at significant risk of distant recurrence up to 15 years following 5 years of endocrine therapy, highlighting the need for further stratification based on individualized risk to select patients for extended endocrine therapy. In this study, the incremental utility of genomic classification to stratify clinically low-risk patients for late distant recurrence was evaluated using the Breast Cancer Index. In 547 T1N0 patients from two cohorts that were disease-free at 5 years post-diagnosis, Breast Cancer Index categorized 32 and 36% from each cohort, respectively, with high risk of late distant recurrence that was associated with significantly reduced distant recurrence-free survival (86.7 and 89.6%) between years 5–15 and 5–10 compared to Breast Cancer Index low risk (95.4%; P = 0.0263 and 98.4%; P = 0.008). Findings support consideration of genomic classification in clinically low-risk hormone receptor–positive patients to identify candidates for extended endocrine therapy.