bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic modeling, adaptive control and energy performance simulation of a hybrid hydronic space heating system
Authors: Ma Yiteng , Zaheeruddin M 
Published: December 2017

A dynamic model of a hybrid hydronic heating system has been developed. The overall model consists of a boiler, a heat exchanger, a ground loop heat pump, a ground loop heat exchanger, baseboard heaters (convector–radiators), and radiant floor hydraulic piping system. Two control strategies for improving the overall system performance were explored: (1) a conventional proportional-integral (PI) control and (2) an adaptive gain control. The simulation results showed that the performance of the adaptive controller is better than the fixed gain PI controller in disturbance rejection and stability. Energy simulations under three different operating strategies were conducted: (1) a fixed set-point PI control, (2) an outdoor air temperature reset control, and (3) an optimal set-point adaptive PI control. It was shown that the outdoor temperature reset strategy can save 4.5 and 19.9% energy under cold day and mild day conditions compared to the fixed set-point PI control strategy. The optimal adaptive PI control strategy resulted in higher energy savings of 6.6 and 22% as compared to the PI control under cold and mild day conditions, respectively. Practical application: Energy efficiency and sustainability are a major issue of importance in the design and operation of space heating systems. The proposed hybrid system combines a ground-source heat pump and a hot water boiler for space heating of both residential and commercial building applications. The heating system consists of radiant floor piping for the residential zones and hot water baseboard heaters (convector–radiators) for the commercial zones. An energy optimal adaptive control strategy is designed to improve energy efficiency and temperature control performance of the hybrid system. The control strategy is simple and can be implemented on the existing building control systems.
The practicalities of establishing a porcine isolated heart model
Authors: Pavey Warren , Raisis Anthea , Dunne Ben , Van Laeken Els , Jenkinson Charles , Vincent Viji , Baird Peter , Prince Stuart , Ho Kwok M. , Merry Christopher , Gilfillan Ian 
Published: December 2017

Background: The isolated heart apparatus is over 100 years old, but remains a useful research tool today. While designs of many large animal systems have been described in the literature, trouble-shooting and refining such a model to yield a stable, workable system has not been previously described. This paper outlines the issues, in tabular form, that our group encountered in developing our own porcine isolated heart rig with the aim of assisting other workers in the field planning similar work. The paper also highlights some of the modern applications of the isolated heart apparatus. Methods Landrace pigs (50-80 kg) were used in a pilot project to develop the model. The model was then used in a study examining the effects of various cardioplegic solutions on function after reanimation of porcine hearts. During the two projects, non-protocol issues were documented as well as their solutions. These were aggregated in this paper. Results: Issues faced by the group without explicit literature solutions included pig size selection, animal acclimatisation, porcine transoesophageal echocardiography, cannulation and phlebotomy for cross-clamping, cardioplegia delivery, heart suspension and rig tuning. Conclusion: Prior recognition of issues and possible solutions faced by workers establishing a porcine isolated heart system will speed progress towards a useable system for research. The isolated heart apparatus remains applicable in transplant, ischaemia reperfusion, heart failure and organ preservation research.
A novel augmented venous-drainage model of cardiopulmonary bypass for deep hypothermic circulatory arrest without blood priming
Authors: Jiang Xuan , Gu Tianxiang , Liu Yu , Wang Chun , Shi Enyi , Zhang Guangwei 
Published: December 2017

Objective: Cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) are commonly used in cardiac surgery. However, the mortality and morbidity are still high in practice. Developing novel protective stategies and elucidating the underlying mechanisms for the pathophysiological consequences of DHCA have been hampered because of the absence of a satisfactory recovery animal model. The aim of this study was to establish a novel and safe DHCA model without blood priming in rats to study the pathophysiology of potential complications. Methods: Ten adult male Sprague-Dawley rats (age, 14-16 weeks; weight, 200-300g) were used. The entire CPB circuit consisted of a modified reservoir, a custom-designed small-volume membrane oxygenator, a roller pump and a home-made heat exchanger, all of which were connected via silicon tubing. The volume of the priming solution was less than 10 ml. The right jugular vein, right carotid artery and left femoral artery were cannulated. The blood was drained from the right atrium through the right jugular vein and fed back to the rat via the left femoral artery. CPB was commenced at a full flow rate. The animals were cooled to a pericranial temperature of 18°C and then subjected to 45 minutes of DHCA with global ischemia. Circulatory arrest was followed by rewarming and over 60 minutes of reperfusion. CPB was terminated carefully. Blood in the circuit was centrifuged and slowly transfused to achieve optimal hematocrit. Blood gas and hemodynamic parameters were recorded at each time point before CPB, during CPB and after CPB. Results: All CPB and DHCA processes were achieved successfully. No rat died in our research. Blood gas analyses at different times were normal. Cardiac function and blood pressure were stable after the operation. The vital signs of all the rats were stable. Conclusion: The novel augmented venous-drainage CPB and DHCA model in rats could be established successfully without blood priming.
Tonic regulation of middle meningeal artery diameter by ATP-sensitive potassium channels
Authors: Syed Arsalan U , Koide Masayo , Brayden Joseph E , Wellman George C 
Published: December 2017

Activation of ATP-sensitive potassium (KATP) channels in arterial smooth muscle (ASM) contributes to vasodilation evoked by a variety of endogenous and exogenous compounds. Although controversial, activation of KATP channels by neuropeptides such as calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) in the trigeminovascular system, including the middle meningeal artery (MMA), has been linked to migraine headache. The objective of the current study was to determine if ongoing KATP channel activity also influences MMA diameter. In the absence of other exogenous compounds, the KATP channel inhibitors glibenclamide and PNU37883A induced constriction of isolated and pressurized MMAs. In contrast, KATP channel inhibition did not alter cerebral artery diameter. Consistent with tonic KATP activity in MMA, glibenclamide also induced ASM membrane potential depolarization and increased cytosolic Ca2+. Inhibitors of cAMP-dependent protein kinase (PKA) abolished basal KATP activation in MMA and caused a marked decrease in sensitivity to the synthetic KATP channel opener, cromakalim. In vivo MMA constriction in response to gibenclamide was observed using two-photon imaging of arterial diameter. Together these results indicate that PKA-mediated tonic KATP channel activity contributes to the regulation of MMA diameter.
Coronary computed tomography in heart transplant patients: detection of significant stenosis and cardiac allograft vasculopathy, image quality, and radiation dose
Authors: Günther Anne , Aaberge Lars , Abildgaard Andreas , Ragnarsson Asgrimur , Edvardsen Thor , Jakobsen Jarl , Andersen Rune 
Published: December 2017

Background Cardiac allograft vasculopathy (CAV) is an accelerated form of atherosclerosis unique to heart transplant (HTX) patients. Purpose To investigate the detection of significant coronary artery stenosis and CAV, determinants of image quality, and the radiation dose in coronary computed tomography angiography (CCTA) of HTX patients with 64-slice multidetector CT (64-MDCT). Material and Methods Fifty-two HTX recipients scheduled for invasive coronary angiography (ICA) were prospectively enrolled and underwent CCTA before ICA with intravascular ultrasound (IVUS). Results Interpretable CCTA images were acquired in 570 (95%) coronary artery segments ≥2 mm in diameter. Sensitivity, specificity, and positive and negative predictive values of CCTA for the detection of segments with significant stenosis (lumen reduction ≥50%) on ICA were 100%, 98%, 7.7%, and 100%, respectively. Twelve significant stenoses were located in segments with uninterpretable image quality or vessel diameter <2 mm; only one was eligible for intervention. IVUS detected CAV (maximal intimal thickness ≥0.5 mm) in 33/41 (81%) patients; CCTA and ICA identified CAV (any wall or luminal irregularity) in 18 (44%) and 14 (34%) of these 33 patients, respectively. The mean estimated radiation dose was 19.0 ± 3.4 mSv for CCTA and 5.7 ± 3.3 mSv for ICA ( P < 0.001). Conclusion CCTA with interpretable image quality had a high negative predictive value for ruling out significant stenoses suitable for intervention. The modest detection of CAV by CCTA implied a limited value in identifying subtle CAV. The high estimated radiation dose for 64-MDCT is of concern considering the need for repetitive examinations in the HTX population.
The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-analysis With Bias Assessment
Authors: Chen Xiao , Jones Ian A. , Park Caron , Vangsness C. Thomas 
Published: December 2017

Background: There has been a surge in high-level studies investigating platelet-rich plasma (PRP) for tendon and ligament injuries. A number of meta-analyses have been published, but few studies have focused exclusively on tendon and ligament injuries. Purpose: To perform a meta-analysis assessing the ability of PRP to reduce pain in patients with tendon and ligament injuries. Study Design: Systematic review and meta-analysis. Methods: This study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search of the literature was carried out in April 2017 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Only level 1 studies were included. Platelet and leukocyte count, injection volume, kit used, participant age/sex, comparator, and activating agent used were recorded. The short-term and long-term efficacy of PRP was assessed using the visual analog scale (VAS) to measure pain intensity. Injury subgroups (rotator cuff, tendinopathy, anterior cruciate ligament, and lateral epicondylitis) were evaluated. Funnel plots and the Egger test were used to screen for publication bias, and sensitivity analysis was performed to evaluate the effect of potential outliers by removing studies one at a time. Results: Thirty-seven articles were included in this review, 21 (1031 participants) of which could be included in the quantitative analysis. The majority of studies published investigated rotator cuff injuries (38.1%) or lateral epicondylitis (38.1%). Seventeen studies (844 participants) reported short-term VAS data, and 14 studies (771 participants) reported long-term VAS data. Overall, long-term follow-up results showed significantly less pain in the PRP group compared with the control group (weighted mean difference [WMD], –0.84; 95% CI, –1.23 to –0.44; P < .01). Patients treated with PRP for rotator cuff injuries (WMD, –0.53; 95% CI, –0.98 to –0.09; P = .02) and lateral epicondylitis (WMD, –1.39; 95% CI, –2.49 to –0.29; P = .01) reported significantly less pain in the long term. Substantial heterogeneity was reported at baseline ( I2 = 72.0%; P < .01), short-term follow-up ( I2 = 72.5%; P < .01), long-term follow-up ( I2 = 76.1%; P < .01), and overall ( I2 = 75.8%; P < .01). The funnel plot appeared to be asymmetric, with some missingness at the lower right portion of the plot suggesting possible publication bias. Conclusion: This review shows that PRP may reduce pain associated with lateral epicondylitis and rotator cuff injuries.
Qualitative and Quantitative Analyses of the Dynamic and Static Stabilizers of the Medial Elbow: An Anatomic Study
Authors: Frangiamore Salvatore J. , Moatshe Gilbert , Kruckeberg Bradley M. , Civitarese David M. , Muckenhirn Kyle J. , Chahla Jorge , Brady Alex W. , Cinque Mark E. , Oleson Morten Lykke , Provencher Matthew T. , Hackett Thomas R. , LaPrade Robert F. 
Published: December 2017

Background: The anterior bundle of the medial ulnar collateral ligament (UCL) and the forearm flexors provide primary static and dynamic stability to valgus stress of the elbow in overhead-throwing athletes. Quantitative anatomic relationships between the dynamic and static stabilizers have not been described. Purpose: To perform qualitative and quantitative anatomic evaluations of the medial elbow-UCL complex with specific attention to pertinent osseous and soft tissue landmarks. Study Design: Descriptive laboratory study. Methods: Ten nonpaired, fresh-frozen human cadaveric elbows (mean age, 54.1 years [range, 42-64 years]; all male) were utilized for this study. Quantitative analysis was performed with a 3-dimensional coordinate measuring device to quantify the location of pertinent bony landmarks and tendon and ligament footprints on the humerus, ulna, and radius. Results: The anterior bundle of the UCL attached 8.5 mm (95% CI, 6.9-10.0) distal and 7.8 mm (95% CI, 6.6-9.1) lateral to the medial epicondyle, 1.5 mm (95% CI, 0.5-2.5) distal to the sublime tubercle, and 7.3 mm (95% CI, 6.1-8.5) distal to the joint line on the ulna along the ulnar ridge. The flexor digitorum superficialis (FDS) ulnar tendinous insertion was closely related and interposed within the anterior bundle of the UCL, overlapping with 45.6% (95% CI, 38.1-53.6) of the length of the anterior bundle of the UCL. The flexor carpi ulnaris (FCU) attached 1.9 mm (95% CI, 0.8-2.9) posterior and 1.3 mm (95% CI, 0.6-3.2) proximal to the sublime tubercle and overlapped with 20.9% (95% CI, 7.2-34.5) of the area of the distal footprint of the anterior bundle of the UCL. Conclusion: The anterior bundle of the UCL had consistent attachment points relative to the medial epicondyle and sublime tubercle. The ulnar limb of the FDS and FCU tendons demonstrated consistent insertions onto the ulnar attachment of the anterior bundle of the UCL. These anatomic relationships are important to consider when evaluating distal UCL tears both operatively and nonoperatively. Excessive stripping of the sublime tubercle should be avoided during UCL reconstruction to prevent violation of these tendinous attachments. Clinical Relevance: The findings of this study enhance the understanding of valgus restraint in throwing athletes and provide insight into the difference in nonoperative outcomes between proximal and distal tears of the UCL.
First Field Test of an Innovative, Wider Tape to Measure Mid-Upper Arm Circumference in Young Laotian Children
Authors: Hess Sonja Y. , Hinnouho Guy-Marino , Barffour Maxwell A. , Bounheuang Bangone , Arnold Charles D. , Bell David , Marts Tola H. , Kounnavong Sengchanh 
Published: December 2017

Background: Measurements of mid-upper arm circumference (MUAC) may result in measurement error due to incorrect placement along the arm or tight pulling of tape. To reduce the risk of these measurement errors, a new wider tape was developed. Objective: To compare the measurement agreement and precision and the ease of use of the standard and wide MUAC tapes. Methods: Mid-upper arm circumference was measured in 814 children aged 9 to 32 months with both tapes. The midpoint of the upper arm was measured with the standard tape and estimated with the wide tape. Standardization sessions were implemented to assess intra- and interobserver precision. Results: Mid-upper arm circumference with the wide MUAC tape was significantly larger than the standard tape (mean [standard deviation]: 14.3 [1.0] cm vs 13.9 [1.0] cm; P < .001), resulting in a consistent bias of +0.41 cm. Forty-six (5.7%) children were identified with low MUAC <12.5 cm by standard tape compared with 10 (1.2%) by the wide tape ( P <.001). Because a new tape could be reproduced by correcting for this bias, we corrected measured results by subtracting 0.41 cm and mean MUAC by tape type was no longer significantly different. Intra- and interobserver technical error of measurement suggested a better precision with the wide MUAC tape. Conclusions: Despite simplifying the measurement by approximating the midpoint of the upper arm, the wide MUAC tape tended to have better precision than the standard MUAC tape. However, there was a consistent measurement bias of +0.41 cm in mean MUAC. This first field test yielded promising results and led to further product adjustments.
Competitive Balance in the NBA Playoffs
Authors: Horowitz Ira 
Published: December 2017

The uncertainty-of-outcome hypothesis suggests that, subject to a rooting-interest constraint, fans prefer competitive sporting events with uncertain outcomes. In a logical extension of that preference, professional-sports leagues institute rules, such as reverse-order-of-finish drafts and salary caps, intended to help achieve competitive balance among their franchises. This article analyzes the results of the 34 National Basketball Association (NBA) playoffs held since 1984 to determine whether they reflect the competitive imbalance observed for regular-season play, relying on the entropy concept as a measure of uncertainty/information content to do so. It is shown that unlike regular-season competitive balance, playoff entropy has not systematically changed over time. JEL Classifications: D47, D84, Z20, Z21
Factors That Influence Campus Dwelling University Students’ Facility to Practice Healthy Living Guidelines
Authors: Walsh Audrey , Taylor Claudette , Brennick Debbie 
Published: December 2017

Background Young adult university students living on campus are at an increased risk of developing lifestyle habits that encourage unintentional weight gain. Purpose The purpose of this study was to identify the individual and contextual factors that influence campus dwelling university students’ facility to practice healthy living guidelines that reduce their risk of unintentional weight gain. Lifestyle practices included nutrition, physical activity, and sleep. Methods For seven days, 48 campus dwelling students recorded their activities and reflected on how closely they were able to follow recommended healthy living guidelines. Recorded data were supplemented by follow-up focus groups. All data were analyzed using thematic analysis. Results Students described multiple factors and conditions that influenced their facility to practice healthy living guidelines for nutrition, activity, and sleep. Many students’ lifestyle practices put them at an increased risk of unintentional weight gain. Conclusions The campus environment challenges student’s facility to practice healthy living guidelines. Nurses can intervene to build individual student capacity and to advocate for environmental polices that increase students’ facility to choose lifestyle practices that promote health, lessen their risk of unintentional weight gain, and reduce their risk of developing chronic illness.
Evaluation of the Project P.A.T.H.S. in Mainland China: Findings Based on Student Diaries
Authors: Shek Daniel T. L. , Zhu Xiaoqin , Leung Janet T. Y. , Lee Tak Yan , Wu Florence K. Y. 
Published: December 2017

Objectives: Based on 859 student diaries, the present study evaluated a positive youth development program entitled “Tin Ka Ping (TKP) Positive Adolescent Training through Holistic Social programs (P.A.T.H.S.) ” project implemented in mainland China during the 2015–2016 academic year. Method: To understand the perceived effectiveness of the students, the study analyzed quantitative as well as qualitative data derived from the student diaries. Results: The students held very positive views toward the program and the implementers. The narratives of the students also showed that they perceived improvement in the intrapersonal, interpersonal, familial, and societal domains after joining the program. Conclusion: In conjunction with the subjective outcome evaluation findings, the present findings suggest that the “TKP P.A.T.H.S.” project is able to promote holistic development of secondary school students in mainland China.
Experiences of Female and Male Medical Students With Death, Dying, and Palliative Care: One Size Does Not Fit All
Authors: Hoffman Leslie A. , Mehta Rakesh , Vu T. Robert , Frankel Richard M. 
Published: December 2017

Background: Medical students learn about death, dying, and palliative care (DDPC) through formal curricular offerings and informal clinical experiences; however, the lessons learned in the clinic may be at odds with the formal curriculum. Reflective writing is a means for students to “bracket” their DDPC experiences and reconcile conflicts between the formal and informal curriculum. Objectives: The aim of this study is to compare the level of reflection demonstrated in medical students’ narratives on DDPC with other experiences and to examine the domains of professionalism that students perceive to be prevalent in their DDPC experiences. Methods: Third-year medical students submitted professionalism narratives during their internal medicine clerkship. We identified a subset of narratives related to DDPC (n = 388) and randomly selected control narratives (n = 153). We assessed the level of reflection demonstrated in the narratives using a validated rubric and analyzed the professionalism domains that students identified as relevant to their experience. Results: There was no difference in reflective level between DDPC and control narratives. Within the DDPC group, female students demonstrated higher reflection (2.24 ± 0.71) than male students (2.01 ± 0.77; P < .001). Caring, compassion and communication, and honor and integrity were prominent among DDPC narratives. More females identified caring, compassion, and communication as relevant to their DDPC experiences, whereas more males identified altruism. Conclusion: Males and females have different perceptions of DDPC experiences, and female students appear to be more deeply impacted. These findings can help clinical faculty engage students more effectively with this challenging topic.
What Is Measured in Bereavement Treatment for Children and Adolescents? A Systematic Literature Review
Authors: de López Kristine Jensen , Søndergaard Knudsen Hanne , Hansen Tia G. B. 
Published: December 2017

Objective Childhood bereavement from parental death can be a significant stressor. Treatment studies vary largely on how the effect of the grief treatment is measured. This sytematic review evaluates whether controlled bereavement intervention studies focus on symptomatalogy or grief as outcome measure and also summarizes the effect of grief treatment. Method For inclusion in the review, studies must report on children or adolesecents who experienced the death of a parent or sibling, must have a control group and must report results of a grief treatment. Results Eight studies met the inclusion criteria and reported in total on 30 different outcome measures. Only two studies measured grief as a separate outcome and both showed promising results for the treatment of grief with bereaved children. Conclusions Systematic use of validated measures of prolonged grief in treatment studies is needed. Implications of the findings and recommendations for future studies are discussed in the perspective of complicated grief becoming part of the 11th Revision of the International Classification of Diseases. Grief interventions for parentally bereaved youth is promising but lack consistent use of reliable grief measures for solid documentation of the effect. The specific role of parenting and culture for the outcome of the intervention should be investigated in more detail.