bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Sinetrol® Xpur on metabolic health and adiposity by interactions with gut microbiota: a randomized, open label, dose–response clinical trial
Authors: Muralidharan Jananee , Romain Cindy , Chung Linda , Alcaraz Pedro , Martínez-Noguera Francisco Javier , Keophiphath Mayoura , Lelouvier Benjamin , Ancel Patricia , Gaborit Benedicte , Cases Julien 
Published: October 2024

Abstract
Background
Sinetrol® Xpur is a polyphenolic ingredient rich in citrus flavonoids that has shown weight loss effects in previous studies. The dose dependent nature, gut microbial actions of this product has not been explored previously, thus presented in this study.

Methods
In this open label study, we evaluated the effect of Sinetrol® Xpur supplementation on healthy but overweight/obese adults (20–50 yrs) for 16 weeks. Participants (n = 20) were randomly allocated to a high dose group (HD, 1800 mg/day) or low dose group (LD, 900 mg/day) of the product for 16 weeks. Fat composition, gut microbial composition, were evaluated using MRI and 16S rDNA sequencing respectively at week 1 and 16.

Results
We observed HDL, HbA1C, LDL and leptin improved significantly over 16 weeks, irrespective of the dosage. There was a trend for decrease in visceral adipose tissue (VAT), BMI over time and body weight displayed a trend for dose dependent decrease. Eubacterium xylanophilum, Ruminococcacea UCG-004 genus which increased in HD and LD respectively were negatively associated to VAT. Both doses increased butyrate producers such as Eubacterium ruminantium and Ruminococcaceae NK4A214 genus.

Conclusions
Overall chronic supplementation of Sinetrol® Xpur, irrespective of their dose improved HDL, HbA1c, LDL and leptin and tended to decrease visceral adipose tissue via changes in gut microbiota.
Trial registration number NCT03823196.
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy
Authors: Prabhakaran Rajkumar , Thamarai Rajkumar , Sivasamy Sivabalan , Dhandayuthapani Sivanesan , Batra Jyoti , Kamaraj Chinnaperumal , Karthik Krishnasamy , Shah Mohd Asif , Mallik Saurav 
Published: October 2024

AbstractCancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefront of cancer research. This review highlights the important roles of DNA methylation, histone modifications and non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs, which are key regulators of cancer-related gene expression. It explores the potential of epigenetic-based therapies to revolutionize patient outcomes by selectively modulating specific epigenetic markers involved in tumorigenesis. The review examines promising epigenetic biomarkers for early cancer detection and prognosis. It also highlights recent progress in oligonucleotide-based therapies, including antisense oligonucleotides (ASOs) and antimiRs, to precisely modulate epigenetic processes. Furthermore, the concept of epigenetic editing is discussed, providing insight into the future role of precision medicine for cancer patients. The integration of nanomedicine into cancer therapy has been explored and offers innovative approaches to improve therapeutic efficacy. This comprehensive review of recent advances in epigenetic-based cancer therapy seeks to advance the field of precision oncology, ultimately culminating in improved patient outcomes in the fight against cancer.
Knowledge behind the scenes of a peer-reviewed journal helps in publishing your manuscript
Authors: Cappitelli Francesca , Villa Federica 
Published: October 2024

AbstractThis paper provides insights into the paper submission and review processes and the possible reasons behind paper acceptance or rejection. The main target of this paper is emerging researchers who are writing their first scientific papers in peer-reviewed journals. This manuscript gives clues on how to select a journal and what a preprint is, introduces authorship and the roles of editors, reviewers, and publishers, sheds light on the editorial process, and briefly introduces some ethical issues arising in scholarly publishing. The content is based on a course offered annually to doctoral students at the University of Milan and keeps into account frequently asked questions. The authors of this paper are an editor-in-chief and an associated editor of scientific journals, respectively.
The relationship between personal-collaborative motivation profiles and students’ performance in collaborative problem solving
Authors: He Jinming , Ren Shixiu , Zhang Danhui 
Published: October 2024

AbstractCollaborative problem solving (CPS), as a twenty-first century skill, is critically important for both living and life-long learning. Motivation in CPS equates to students’ needs to recognize their efforts in collaboration. Given the complexity of CPS contexts, the intertwined relationship among different types of motivations was investigated using a person-centred approach to identify different configural profiles of collaborators based on PSI ($$\psi$$
ψ
) theory. A total of 9398 Chinese students in 264 schools were included in this study. Latent profile analysis was used to identify four profiles of students with different CPS motivations: “Achievement-oriented cooperator” (n = 773), “Instrument-oriented Cooperator” (n = 1539), “Achievement-oriented nonteam player” (n = 1202), and “Instrument-oriented nonteam player” (n = 5884). Their psychological attributes and CPS behaviours were further analysed, with the following results: (1) achievement-oriented cooperators performed the best, while instrument-oriented nonteam players performed the worst; and (2) students who are achievement-oriented and value collaboration with others are more likely to engage in CPS tasks. These findings provide insights into how different motivational configurations influence CPS behaviours, offering practical implications for enhancing collaboration in educational settings.
Estimating the individual stillborn rate from easy-to-collect sow data on farm: an application of the bayesian network model
Authors: Teixeira Costa Charlotte , Boulbria Gwenaël , Dutertre Christophe , Chevance Céline , Nicolazo Théo , Normand Valérie , Jeusselin Justine , Lebret Arnaud 
Published: October 2024

Abstract
Background
A high number of stillborn piglets has a negative impact on production and animal welfare. It is an important contributor to piglet mortality around farrowing and continues to rise with the increase of prolificacy. The objective of this study was to build a predictive model of the stillborn rate.

Results
This study was performed on two farrow-to-finish farms and one farrow-to-wean farm located in Brittany, France. At each farm, the number of total born (TB), born alive (BA), stillborn piglets (S), the same data at the previous farrowing (TBn− 1, BAn− 1 and Sn− 1), backfat thickness just before farrowing and at previous weaning and parity rank were recorded in our dataset of 3686 farrowings. Bayesian networks were used as an integrated modelling approach to investigate risk factors associated with stillbirth using BayesiaLab® software. Our results suggest the validity of a hybrid model to predict the percentage of stillborn piglets. Three significant risk factors were identified by the model: parity rank (percentage of total mutual information: MI = 64%), Sn− 1 (MI = 25%) and TBn− 1 (MI = 11%). Additionally, backfat thickness just before farrowing was also identified for sows of parity five or more (MI = 0.4%). In practice, under optimal conditions (i.e., low parity rank, less than 8% of stillborn piglets, and a prolificacy lower than 14 piglets at the previous farrowing), our model predicted a stillborn rate almost halved, from 6.5% (mean risk of our dataset) to 3.5% for a sow at the next farrowing. In contrast, in older sows with a backfat thickness less than 15 mm, more than 15% of stillborn and a prolificacy greater than 18 piglets at the previous farrowing, the risk is multiplied by 2.5 from 6.5 to 15.7%.

Conclusion
Our results highlight the impact of parity, previous prolificacy and stillborn rate on the probability of stillborn. Moreover, the importance of backfat thickness, especially in old sows, must be considered. This information can help farmers classify and manage sows according to their risk of giving birth to stillborn piglets.
Daily exercises uptake and associated factors among Social Security and National Insurance Trust pensioners in the Greater Accra Region of Ghana
Authors: Ongoh Myles , Abekah-Carter Kwamina , A-iyeh Edmond , Agyemang-Duah Williams 
Published: October 2024

Abstract
Background
With a growing body of evidence highlighting the positive impact of regular physical activity or exercise on achieving healthy aging, it is important to gain insight into the factors influencing daily exercises uptake. However, to the best of our knowledge, no study has been focused on factors predicting daily exercises uptake among pensioners, who form a substantial portion of Ghana’s aging population. The goal of this preliminary study was to estimate the factors associated with daily exercises uptake among Social Security and National Insurance Trust (SSNIT) pensioners in Ghana.

Methods
Data for this study came from a cross-sectional study on survival strategies and quality of life among SSNIT pensioners in the Greater Accra Region of Ghana. Cluster and stratified sampling techniques were used to recruit the study participants. The analytic sample was 410 participants. Multivariable binary logistic regressions were used to estimate factors associated with daily exercises uptake among the participants. The significance of the test was pegged at a p-value of 0.05 or less.

Results
The results showed that 62% of the participants self-identified as male, 47.6% were aged between 60 and 64 years, 52.7% were employed in the public sector and 44.4% performed daily exercises. The results showed that those who were aged 60–64 years (AOR: 1.197, 95% CI: 1.019–1.405), aged 65–69 years (AOR:1.254, 95% CI: 1.071–1.468), who do not incur expenditure on their household in a month (AOR: 1.519, 95% CI: 1.127–2.046), earned less than GH¢260 (AOR: 1.221, 95% CI: 1.018–1.465), accessed/utilized herbalist medical services (AOR: 1.252, 95% CI: 1.129–1.388), very dissatisfied (AOR: 1.637, 95% CI: 1.242–2.157) and dissatisfied (AOR: 1.516, 95% CI: 1.212–1.896) with their sex life were more likely to undertake daily exercises and this was statistically significant. The results again demonstrated that participants who joined fitness club (AOR: 0.685, 95% CI: 0.614-0.764) and those who were very dissatisfied with their health services access/use (AOR: 0.598, 95% CI: 0.363-0.984) were less likely to undertake daily exercises and this was statistically significant.

Conclusion
Findings of this study have provided important insights for policy makers and thus constitute a useful framework to help plan and shape future policies and programs on daily exercises uptake among pensioners in Ghana and other geographical contexts with similar cultural, demographic, and socio-economic characteristics.
Genetic underpinnings of neonatal diabetes: a review of current research
Authors: Golshan-Tafti Mohammad , Dastgheib Seyed Alireza , Bahrami Reza , Yeganegi Maryam , Aghasipour Maryam , Marzbanrad Zahra , Saeida-Ardekani Maryam , Shahbazi Amirhossein , Omidi Amirhossein , Lookzadeh Mohamad Hosein , Mirjalili Seyed Reza , Noorishadkam Mahmood , Neamatzadeh Hossein 
Published: October 2024

AbstractNeonatal diabetes mellitus (NDM) is a rare, insulin-dependent diabetes that manifests within the first month of life and requires insulin therapy for management. NDM is categorized into two primary types: transient NDM (TNDM), which typically resolves during infancy or early childhood, and permanent NDM (PNDM), necessitating lifelong insulin treatment. TNDM has an incidence of approximately 1 in 90,000 to 160,000 live births and is characterized by insulin-dependent hyperglycemia that usually resolves within 12 weeks but may relapse in later adolescence or early adulthood. Congenital manifestations often include intrauterine growth restriction (IUGR), macroglossia, and umbilical hernia, with its etiology linked to epigenetic alterations on chromosome 6q24 that affect the transcription factor PLAGL1. In contrast, PNDM occurs with an incidence ranging from 1 in 108,999 to 1 in 1,029,999 live births and presents with persistent hyperglycemia requiring lifelong insulin therapy. It is primarily associated with mutations in over 49 genes, particularly KCNJ11 and ABCC8, which disrupt ATP-sensitive potassium channels, while some cases involve mutations in the insulin gene that affect β-cell function. Treatment mainly consists of insulin therapy, although some patients may transition to oral sulfonylureas. Long-term follow-up by a multidisciplinary pediatric team is crucial, as individuals with NDM may experience recurrent diabetes and neurological or neuropsychological issues. Insulin therapy is an effective approach for managing NDM, necessitating meticulous monitoring of blood glucose levels to reduce the risk of long-term complications. Genetic testing is essential for diagnosing both types of NDM and informing treatment strategies, including the potential use of oral sulfonylureas for PNDM. Ongoing research into the genetic mechanisms and long-term management approaches is vital for enhancing clinical outcomes and monitoring complications in affected individuals.
Comparison of efficacy of long follicular phase regimen and antagonist regimen on pregnancy outcome of fresh cycle or freeze-thawed cycle embryo transfer
Authors: Li Pengtao , Zhai Jiawei , Liu Ting , Guo Mengyuan , Wang Yuzhen 
Published: October 2024

Objective: To compare the pregnancy outcome of the fresh cycle or freeze-thaw cycle embryo transfer of patients treated with a long follicular phase regimen and antagonist regimen, and explore the clinical therapeutic effect of the two regimens.
Methods: This was a retrospective study. The data of a total of 543 patients who underwent in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) or frozen-thawed embryo transfer (FET) in Baoding Maternal and Child Health Care Hospital from January 2020 to December 2022 were retrospectively analyzed in this study and were divided into four group to analyze the basic conditions, medication, laboratory indicators and clinical outcomes after embryo transfer of patients in each group.
Results: The pregnancy rate and implantation rate in Groups A, B and C were higher than those in Group-D, and the differences were statistically significant (p<0.05). The difference in multiple pregnancy rate and abortion rate among groups was not statistically significant (p>0.05). The influencing factors of clinical pregnancy rate were identified by binary Logistic regression analysis. Advanced age was found to be a risk factor for improving the pregnancy rate, while the increase in the number of oocytes retrieved is a protective factor for improving the pregnancy rate. The differences were statistically significant (p<0.05).
Conclusion: The antagonist regimen has a low dosage and short medication time and can achieve a high embryo utilization rate and blastula formation rate, saving time and cost for patients.
doi: https://doi.org/10.12669/pjms.40.10.9050
How to cite this: Li P, Zhai J, Liu T, Guo M, Wang Y. Comparison of efficacy of long follicular phase regimen and antagonist regimen on pregnancy outcome of fresh cycle or freeze-thawed cycle embryo transfer. Pak J Med Sci. 2024;40(10):2170-2175. doi: https://doi.org/10.12669/pjms.40.10.9050
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Postoperative analgesia in patients undergoing thoracotomy: A comparison between total intravenous anesthesia and inhalation anesthesia
Authors: Lee Jooyong , Jeong Soontaek , Hwang Jihye , Park Sanghi 
Published: October 2024

Objective: Propofol is more effective than inhalational anesthesia; however, the results for the management of acute pain remain controversial. Therefore, this study aimed to determine the incidence of acute pain after inhalation anesthesia and total intravenous anesthesia among patients who underwent thoracotomy at our hospital. Methods: We conducted a single center retrospective observational study using data from electronic medical records. Sixty patients aged ≥20 years with American Society of Anesthesiologists physical status class I or II who underwent regular and emergency thoracotomy between January 1, 2016, and January 1, 2020, at Chungbuk National University Hospital were included in this study. The anesthesia and postoperative pain records of those who received total intravenous anesthesia (n=30) and inhalation anesthesia (n=30) were retrospectively reviewed. The pain score on the numeric rating scale (NRS) was evaluated at 2, 8, 24, and 30 hours postoperatively. Results: The average NRS score of patients who received total intravenous anesthesia was lesser than that of those who received inhalational anesthesia. Moreover, the difference in the NRS scores at eight hours postoperatively was statistically significant (P <0.05). Patients who received inhalational anesthesia had a higher pain score and experienced more severe pain than those who received intravenous anesthesia. Conclusions: Total intravenous anesthesia with propofol-remifentanil provided better analgesia for acute postoperative pain in patients who underwent thoracotomy than inhalational anesthesia, suggesting it may be considered the combination of choice for thoracic surgery.Abbreviations: ASA: American Society of Anesthesiologists, CRTS: Chronic post-thoracotomy pain syndrome,
GABA: Gamma-aminobutyric acid, IL: Interleukin, NRS: numeric rating scale.doi: https://doi.org/10.12669/pjms.40.10.9907How to cite this: Lee JY, Jeong ST, Hwang JH, Park SH. Postoperative analgesia in patients undergoing thoracotomy: A comparison between total intravenous anesthesia and inhalation anesthesia. Pak J Med Sci. 2024;40(10):2219-2222. doi: https://doi.org/10.12669/pjms.40.10.9907This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Auditor Skill Demands and Audit Quality: Evidence from Job Postings
Authors: Ham Charles , Hann Rebecca N. , Rabier MaryJane , Wang Wenfeng 
Published: October 2024

This study empirically examines the relation between audit quality and auditors’ cognitive and social skills. Using a novel data set of online job postings by accounting firms, we document substantial variation in the stated demand for auditors’ cognitive and social skills, suggesting that audit offices are not homogeneous in their preferences for such skills. We find a positive relation between audit quality and the prevalence of cognitive and social skills within an audit office’s job postings. This association is stronger for audit engagements that are more complex or require greater coordination, suggesting that cognitive and social skills are particularly important in engagements where effective communication and knowledge transfer, as well as sound professional judgment and skepticism, are needed. The association is also stronger for audit offices with greater investments in new technology, consistent with the complementary relation between cognitive and social skills and the use of technology. Overall, our study offers empirical evidence linking specific auditor skills to audit quality. This paper was accepted by Suraj Srinivasan, accounting. Funding: C. Ham acknowledges financial support from the Blanche “Peg” Philpott Faculty Fellowship. R. N. Hann acknowledges financial support from KPMG. W. Wang acknowledges the financial support from the Hong Kong Research Grant Council [Grant 11503720]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01640 .
Point-of-care ultrasound in resource-limited environments: a review
Authors: O'Kelly Aebhric 
Published: October 2024

Ultrasound is a standard assessment modality in hospital and prehospital settings. It is becoming more accessible in remote, austere and resource-limited environments. Aim: This article aims to review the literature on the use of point-of-care ultrasound (POCUS) imaging in low- to medium-income countries (LMICs) and by practitioners working in remote and austere out-of-hospital environments. Methods: Fifteen articles published between 2019 and 2023 found via PubMed were identified and analysed. Results: The 15 papers present the use of ultrasound imaging by practitioners in LMICs: six were systemic reviews; five were narrative reviews; two were randomised clinical trials; and two were case studies. Conclusions: Few articles focusing on POCUS use in LMICs were published over the five-year period. However, the number of publications increased over the years. Of the 15 studies in this review, six (40%) were systematic reviews, five (33%) were narrative reviews, two (13%) were random clinical trials and two (13%) were case studies. All studies were conducted in district hospitals or other resource-limited environments. The studies have revealed a significant increase in POCUS use over the past few years, with the majority of the devices now being smartphone-based. This is a promising development in POCUS use in austere environments.
Wristwatches in bare-below-the-elbows out-of-hospital policies: time for a review
Authors: Strudwick Thomas 
Published: October 2024

Background: Bare-below-the-elbows (BBE) policies are common in infection prevention and control strategies but the evidence relating to wristwatch prohibition is slim and varied in quality. No dispensation is considered for those working outside hospital, which poses unique infection prevention and control challenges. Blanket approaches may be putting patients at further risk of healthcare-acquired infections (HCAIs). Aims: This review aimed to collate evidence and bring clarity to the ongoing debate surrounding mandated BBE policy, specifically relating to wristwatches worn within the prehospital setting. Methods: Three searches were undertaken, and results refined against an inclusion criterion to ensure relevance. Findings: Wristwatches can be considered a vector for HCAI; however, most data on this are confounded by other known risk factors. No studies were conducted outside a hospital environment. Alternative time sources used by clinicians such as touchscreen phones are a significant pathogen vector. Conclusion: Four policy evidence-based recommendations are made in relation to this topic. The National Institute for Health and Care Excellence (NICE) should review this topic as the evidence base underpinning its guidance is inadequate.