bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol induced Parkinsonism in an ex-pugilist
Authors: Byrne Alan , Delaney William , Boardman R H , Bawa Hussam 
Published: March 2016

AbstractThe case of an ex-pugilist who developed a reversible Parkinsonian syndrome in response to ethanol intoxication, is described. The relationship between ethanol abuse and altered function in the nigro-striatal system is examined, and the relationship to boxing encephalopathy is reviewed. The patient described was the third neurological casualty in a family of boxing brothers, and suggestions are made regarding the potential dangers of this sport. The syndrome of alcohol induced Parkinsonism in an ex-pugilist has not previously been described in the literature.
Neural integration of the hormonal contribution to homeostasis
Authors: Breathnach CS 
Published: March 2016

AbstractApart from well known areas of overlap between endocrinology and psychiatry (e.g. studies, in psychiatric disorders, of neurohormones and of the response to manipulations of hypothalamic-pituitary-target gland axis, and analysis of behavioural and psychological disturbances in endocrinological disorders) there is a more intimate intrinsic relationship between the brain and the endocrine system which is less well known or studied. Many of the extracranial endocrine glands have autonomic innervation. Like the pituitary gland which is under direct neural (as well as humoral) diencephalic control, the extracranial endocrine glands are under direct neural control, integrated by the hypothalamus and “head ganglion of the autonomic nervous system”. Yet it is only in the case of the pancreatic islets that this integration has been clearly defined. It is postulated that by this innervation the somatic endocrine glands can respond to homeostatic needs with a rapid initial secretion before the more sustained outpouring of humoral agents typically regulated by blood-borne constituents including pituitary hormones. This is a vast area awaiting further investigation.
Current issues in monoamine oxidase inhibitor treatment
Authors: O'Brien Sinead , McKeon Patrick 
Published: March 2016

AbstractInterest in the monoamine oxidase (MAO) inhibitors has been revived over the past fifteen years since the publication of studies and reviews which argue their relative safety and efficacy in certain patient subgroups. The authors conclude that there is a continuing role for the MAO inhibitors in treating atypical depressive illness and panic disorders. Careful selection of patients to be commenced on MAO inhibitor treatment is advised. When prescribed alone or in combination with lithium there is evidence to support a usefulness for MAO inhibitors in depression resistant to the tricyclic antidepressants. Their efficacy in the depressed phase of bipolar affective disorder or in combination with the tricyclic antidepressants remains unproven. The risk of anaesthesia while a patient is receiving MAO inhibitor treatment may be less than heretofore believed. There is realistic hope of finding among the short-acting selective MAO inhibitors an effective antidepressant which is also free from tyramine related effects. With the increasing difficulties of evaluating new drugs on account of ethical and governmental constraints, it may however be some time before the preliminary hopeful findings can be substantiated in larger groups of patients.
Serological markers of hepatitis B in long-stay patients in a psychiatric hospital
Authors: Gannon Miriam A. , Murphy Denis J. , Corish John F. 
Published: March 2016

AbstractHepatitis B surface antigen and antibody to hepatitis B core antigen were measured in 232 long-term psychiatric patients. The aims of the study were to determine the prevalence of infection and to relate it to factors such as age, sex, duration of hospital stay and diagnosis.There was both an increased rate and increased evidence of past infection amongst the patients tested relative to the general population. There was no statistical significant difference between the antibody positive group compared to the antibody negative group for age, sex and duration of hospital stay, unlike that found in studies of mentally handicapped patients. There was a positive association between the presence of antibody and patient diagnosis. Patients with mental handicap appear to have a predilection for hepatitis B.Further work needs to be done to elucidate the epidemiology of hepatitis B in psychiatric patients and evaluate the reservoir of infection present.
Reversible sperm changes in an abstinent alcoholic
Authors: Katta Balaraju B , Taneja Neelum , Mohan D 
Published: March 2016

AbstractAlcohol is a reproductive toxin in animals but little is known about its effects on the production of semen in humans. Nothing is known about the reversibility of any changes. The authors here present a case of alcohol dependence with abnormal semen parameters which improved after two months total abstinence.
Further thoughts on Graz 807 and Vienna 13314
Authors: NORTON MICHAEL LEE 
Published: March 2016

ABSTRACTGraz, University Library, MS 807 and Vienna, Austrian National Library, latin 13314 have been studied intensively for more than a century, yet unsolved problems remain. Following a brief discussion of the sources and relevant scholarship, the antiphons for the Rogationtide processions in the gradual portions of both manuscripts I examine, along with a supplementary set of Rogationtide antiphons added to the Vienna codex. I then take a closer look at the expanded descriptions for the rites for Holy Thursday, Good Friday and Holy Saturday in the Vienna manuscript's sacramentary. From this evidence, I reaffirm the association of the liturgies in Vienna 13314 and Graz 807 with the canons and canonesses of Klosterneuburg respectively, and argue that the twelfth-century additions to Vienna 13314 suggest that the two manuscripts were kept together already in the twelfth century, most likely at the Augustinian monastery at Seckau. I conclude with further observations on the much-discussed odd placement of the Dedication of the Church in the Sanctorale of Graz 807 and on the occasion that would have brought the two manuscripts to Seckau.
Recent recordings of plainchant
Authors: WEBER JEROME F. 
Published: March 2016

The latest entry in the traversal of Graduale Novum 1, the AISCGre edition of restitutions of Mass Propers, arrived too late for last year's roundup of new recordings (no. 1 in the list below). It offers the Propers for the eleventh to the fifteenth Sundays in Ordinary Time. The title, ‘Gustate et Videte’, comes from the incipit of the communion for the fourteenth Sunday. The chants are sung in the best semiological interpretation with superb choral tone. The notes are interesting for a wry explanation of the lack of correspondence between the new liturgical calendar and the old. The first four sets of Propers on this disc match the fifth to the eighth Sundays after Pentecost, but the last set come from the tenth Sunday after Pentecost (with the exception of the communion). Because of the imprecatory introit of the ninth Sunday after Pentecost, averte mala inimicis meis . . . disperde illos, this set was passed over. The editors of the 1970 Roman Missal, on second thought, decided, upon reaching the sixteenth Sunday of the Year, to restore the missing chants (except the communion) to that service, while removing the offending lines in favour of another verse from the same psalm. (As the Graduale Triplex shows, the text of the introit escaped the tampering.) At this moment, EOS has three more CDs awaiting issue by three of the directors who have contributed earlier discs to the series. The second volume of Graduale Novum is expected to be published in 2017.
Influence of Educational Attainment on Cognition-Based Intervention Programs for Persons with Mild Alzheimer’s Disease
Authors: Contador Israel , Fernández-Calvo Bernardino , Ramos Francisco , Olazarán Javier 
Published: March 2016

AbstractObjectives: This research retrospectively analyzed the effect of education on cognitive interventions carried out in patients with mild Alzheimer’s disease (AD). Methods: The total sample consisted of 75 patients with mild AD receiving treatment with cholinesterase inhibitors. The participants were divided into two groups: cognitive intervention (IG; n=45) and waiting list (WLG; n=30). Patients in the IG received either the Big Brain Academy (n=15) or the Integrated Psychostimulation Program (n=30) during 12 weeks. The influence of education on intervention effect was analyzed comparing mean change scores of the two study groups in the cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-cog), stratified by educational level. The potential effect of age, sex, cognitive status, and type of intervention was examined using post hoc stratification analyses. Results: Higher education was associated with faster cognitive decline in the WLG (effect size=0.51; p<.01). However, cognitive evolution was not influenced by education in the IG (effect size=0.12; p=.42). Conclusions: Our results suggest that cognitive intervention might delay accelerated cognitive decline in higher educated individuals with mild AD. (JINS, 2016, 23, 1–6)
Effect of inbreeding and individual increase in inbreeding on growth in Nilagiri and Sandyno breeds of sheep
Authors: Venkataramanan R. , Subramanian A. , Sivaselvam S.N. , Sivakumar T. , Sreekumar C. , Iyue M. 
Published: March 2016

SummaryIndividual increase in inbreeding coefficients (ΔFi) has been recommended as an alternate measure of inbreeding. It can account for the differences in pedigree knowledge of individual animals and avoids overestimation due to increased number of known generations. The effect of inbreeding (F) and equivalent inbreeding (EF) calculated fromΔFi, on growth traits were studied in Nilagiri and Sandyno flocks of sheep. The study was based on data maintained at the Sheep Breeding Research Station, Sandynallah. The pedigree information and equivalent number of generations were less in Sandyno compared with Nilagiri sheep. The average F and EF for the Nilagiri population were 2.17 and 2.44, respectively and the corresponding values for Sandyno sheep were 0.83 and 0.84, respectively. The trend of inbreeding over years in both the populations indicated that EF was higher during earlier generations when pedigree information was shallow. Among the significant effects of inbreeding, the depression in growth per 1 percent increase in inbreeding ranged from 0.04 kg in weaning weight to 0.10 kg in yearling weight. In general, more traits were affected by inbreeding in Nilagiri sheep, in which greater regression of growth traits was noticed with F compared with EF. Higher values of EF than F in earlier generations in both the populations indicate that EF avoided the potential overestimation of inbreeding coefficient during recent generations. In the Sandyno population, the magnitude of depression noticed among growth traits with significant effects of inbreeding was higher. The differences in response to F and EF noticed in the two populations and possible causes for the trait wise differences in response to F and EF are appropriately discussed.
Nesting-driven multipolar order in CeB6 from photoemission tomography
Authors: Koitzsch A. , Heming N. , Knupfer M. , Büchner B. , Portnichenko P. Y. , Dukhnenko A. V , Shitsevalova N. Y. , Filipov V. B. , Lev L. L. , Strocov V. N. , Ollivier J. , Inosov D. S. 
Published: March 2016

AbstractSome heavy fermion materials show so-called hidden-order phases which are invisible to many characterization techniques and whose microscopic origin remained controversial for decades. Among such hidden-order compounds, CeB6 is of model character due to its simple electronic configuration and crystal structure. Apart from more conventional antiferromagnetism, it shows an elusive phase at low temperatures, which is commonly associated with multipolar order. Here we show that this phase roots in a Fermi surface instability. This conclusion is based on a full 3D tomographic sampling of the electronic structure by angle-resolved photoemission and comparison with inelastic neutron scattering data. The hidden order is mediated by itinerant electrons. Our measurements will serve as a paradigm for the investigation of hidden-order phases in f-electron systems, but also generally for situations where the itinerant electrons drive orbital or spin order.
A test-retest dataset for assessing long-term reliability of brain morphology and resting-state brain activity
Authors: Huang Lijie , Huang Taicheng , Zhen Zonglei , Liu Jia 
Published: March 2016

AbstractWe present a test-retest dataset for evaluation of long-term reliability of measures from structural and resting-state functional magnetic resonance imaging (sMRI and rfMRI) scans. The repeated scan dataset was collected from 61 healthy adults in two sessions using highly similar imaging parameters at an interval of 103–189 days. However, as the imaging parameters were not completely identical, the reliability estimated from this dataset shall reflect the lower bounds of the true reliability of sMRI/rfMRI measures. Furthermore, in conjunction with other test-retest datasets, our dataset may help explore the impact of different imaging parameters on reliability of sMRI/rfMRI measures, which is especially critical for assessing datasets collected from multiple centers. In addition, intelligence quotient (IQ) was measured for each participant using Raven’s Advanced Progressive Matrices. The data can thus be used for purposes other than assessing reliability of sMRI/rfMRI alone. For example, data from each single session could be used to associate structural and functional measures of the brain with the IQ metrics to explore brain-IQ association.
Genome-scale DNA methylome and transcriptome profiling of human neutrophils
Authors: Chatterjee Aniruddha , Stockwell Peter A. , Rodger Euan J. , Morison Ian M. 
Published: March 2016

AbstractMethylation of DNA molecules is a key mechanism associated with human disease, altered gene expression and phenotype. Using reduced representation bisulphite sequencing (RRBS) technology we have analysed DNA methylation patterns in healthy individuals and identified genes showing significant inter-individual variation. Further, using whole genome transcriptome analysis (RNA-Seq) on the same individuals we showed a local and specific relationship of exon inclusion and variable DNA methylation pattern. For RRBS, 363 million, 100-bp reads were generated from 13 samples using Illumina GAII and HiSeq2000 platforms. Here we also present additional RRBS data for a female pair of monozygotic twins that was not described in our original publication. Further, We performed RNA-Seq on four of these individuals, generating 174 million, 51-bp high quality reads on an Illumina HiSeq2000 platform. The current data set could be exploited as a comprehensive resource for understanding the nature and mechanism of variable phenotypic traits and altered disease susceptibility due to variable DNA methylation and gene expression patterns in healthy individuals.
Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique
Authors: Agrawal Rupesh , Smart Thomas , Nobre-Cardoso João , Richards Christopher , Bhatnagar Rhythm , Tufail Adnan , Shima David , H. Jones Phil , Pavesio Carlos 
Published: March 2016

AbstractA pilot cross sectional study was conducted to investigate the role of red blood cells (RBC) deformability in type 2 diabetes mellitus (T2DM) without and with diabetic retinopathy (DR) using a dual optical tweezers stretching technique. A dual optical tweezers was made by splitting and recombining a single Nd:YAG laser beam. RBCs were trapped directly (i.e., without microbead handles) in the dual optical tweezers where they were observed to adopt a “side-on” orientation. RBC initial and final lengths after stretching were measured by digital video microscopy and a Deformability index (DI) calculated. Blood from 8 healthy controls, 5 T2DM and 7 DR patients with respective mean age of 52.4yrs, 51.6 yrs and 52 yrs was analysed. Initial average length of RBCs for control group was 8.45 ± 0.25 μm, 8.68 ± 0.49 μm for DM RBCs and 8.82 ± 0.32 μm for DR RBCs (p < 0.001). The DI for control group was 0.0698 ± 0.0224 and that for DM RBCs was 0.0645 ± 0.03 and 0.0635 ± 0.028 (p < 0.001) for DR group. DI was inversely related to basal length of RBCs (p = 0.02). DI of RBC from DM and DR patients was significantly lower in comparison with normal healthy controls. A dual optical tweezers method can hence be reliably used to assess RBC deformability.
Deep Learning in Label-free Cell Classification
Authors: Chen Claire Lifan , Mahjoubfar Ata , Tai Li-Chia , Blaby Ian K. , Huang Allen , Niazi Kayvan Reza , Jalali Bahram 
Published: March 2016

AbstractLabel-free cell analysis is essential to personalized genomics, cancer diagnostics, and drug development as it avoids adverse effects of staining reagents on cellular viability and cell signaling. However, currently available label-free cell assays mostly rely only on a single feature and lack sufficient differentiation. Also, the sample size analyzed by these assays is limited due to their low throughput. Here, we integrate feature extraction and deep learning with high-throughput quantitative imaging enabled by photonic time stretch, achieving record high accuracy in label-free cell classification. Our system captures quantitative optical phase and intensity images and extracts multiple biophysical features of individual cells. These biophysical measurements form a hyperdimensional feature space in which supervised learning is performed for cell classification. We compare various learning algorithms including artificial neural network, support vector machine, logistic regression, and a novel deep learning pipeline, which adopts global optimization of receiver operating characteristics. As a validation of the enhanced sensitivity and specificity of our system, we show classification of white blood T-cells against colon cancer cells, as well as lipid accumulating algal strains for biofuel production. This system opens up a new path to data-driven phenotypic diagnosis and better understanding of the heterogeneous gene expressions in cells.
RETRACTED ARTICLE: MicroRNA-454 regulates stromal cell derived factor-1 in the control of the growth of pancreatic ductal adenocarcinoma
Authors: Fan Yue , Xu Li-Li , Shi Chen-Ye , Wei Wei , Wang Dan-Song , Cai Ding-Fang 
Published: March 2016

AbstractPancreatic ductal adenocarcinoma (PDAC) is a highly malignant carcinoma with an extremely high lethality. We recently reported that hypoxia-inducible factor 1 (HIF-1) targets quiescin sulfhydryl oxidase 1 to facilitate PDAC cell growth and invasion. Here, we analyzed the control of another HIF-1 target, stromal cell derived factor-1 (SDF-1), in PDAC cells. We detected significantly more CD68+ macrophages in the PDAC, compared to normal human pancreas (NT). Since macrophages are recruited to the tissue through their expression of CXCR4 in response to SDF-1, we thus examined the SDF-1 levels in the PDAC specimens. Surprisingly, the SDF-1 protein but not mRNA significantly increased in PDAC, compared to NT. Moreover, a SDF-1-targeting microRNA, miR-454, was found to decrease in PDAC. Promoter luciferase assay confirmed that bindings of miR-454 to 3′-UTR of SDF-1 mRNAs inhibited SDF-1 protein translation. Co-culture of bone marrow derived macrophages and miR-454-modified PDAC cells in a transwell migration experiment showed that macrophages migrated less towards miR-454-overexpressing PDAC cells and migrated more towards miR-454-depleted cells. Implanted miR-454-depleted PDAC cells grew significantly faster than control, while implanted miR-454-overexpressing PDAC cells grew significantly slower than control. Together, our data suggest that miR-454 may regulate SDF-1 in the control of the growth of PDAC.
Is there an optimal basis to maximise optical information transfer?
Authors: Chen Mingzhou , Dholakia Kishan , Mazilu Michael 
Published: March 2016

AbstractWe establish the concept of the density of the optical degrees of freedom that may be applied to any photonics based system. As a key example of this versatile approach we explore information transfer using optical communication. We demonstrate both experimentally, theoretically and numerically that the use of a basis set with fields containing optical vortices does not increase the telecommunication capacity of an optical system.
Interface Engineering to Create a Strong Spin Filter Contact to Silicon
Authors: Caspers C. , Gloskovskii A. , Gorgoi M. , Besson C. , Luysberg M. , Rushchanskii K. Z. , Ležaić M. , Fadley C. S. , Drube W. , Müller M. 
Published: March 2016

AbstractIntegrating epitaxial and ferromagnetic Europium Oxide (EuO) directly on silicon is a perfect route to enrich silicon nanotechnology with spin filter functionality. To date, the inherent chemical reactivity between EuO and Si has prevented a heteroepitaxial integration without significant contaminations of the interface with Eu silicides and Si oxides. We present a solution to this long-standing problem by applying two complementary passivation techniques for the reactive EuO/Si interface: (i) an in situ hydrogen-Si (001) passivation and (ii) the application of oxygen-protective Eu monolayers–without using any additional buffer layers. By careful chemical depth profiling of the oxide-semiconductor interface via hard x-ray photoemission spectroscopy, we show how to systematically minimize both Eu silicide and Si oxide formation to the sub-monolayer regime–and how to ultimately interface-engineer chemically clean, heteroepitaxial and ferromagnetic EuO/Si (001) in order to create a strong spin filter contact to silicon.
Dioxins reformation and destruction in secondary copper smelting fly ash under ball milling
Authors: Cagnetta Giovanni , Hassan Mohammed Mansour , Huang Jun , Yu Gang , Weber Roland 
Published: March 2016

AbstractSecondary copper recovery is attracting increasing interest because of the growth of copper containing waste including e-waste. The pyrometallurgical treatment in smelters is widely utilized, but it is known to produce waste fluxes containing a number of toxic pollutants due to the large amount of copper involved, which catalyses the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (“dioxins”). Dioxins are generated in secondary copper smelters on fly ash as their major source, resulting in highly contaminated residues. In order to assess the toxicity of this waste, an analysis of dioxin-like compounds was carried out. High levels were detected (79,090 ng TEQ kg−1) in the ash, above the Basel Convention low POPs content (15,000 ng TEQ kg−1) highlighting the hazardousness of this waste. Experimental tests of high energy ball milling with calcium oxide and silica were executed to assess its effectiveness to detoxify such fly ash. Mechanochemical treatment obtained 76% dioxins reduction in 4 h, but longer milling time induced a partial de novo formation of dioxins catalysed by copper. Nevertheless, after 12 h treatment the dioxin content was substantially decreased (85% reduction) and the copper, thanks to the phenomena of incorporation and amorphization that occur during milling, was almost inactivated.