bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment strategies for revision surgery of artificial urinary sphincter: A review
Authors: Kaiho Yasuhiro , Oikawa Masaaki , Kusumoto Hiroki , Kukimoto Takashi , Morozumi Kento , Ito Jun 
Published: September 2024

AbstractArtificial urinary sphincters (AUS) are an effective treatment for male stress urinary incontinence (SUI). However, infection, erosion, mechanical failure, atrophy, and balloon deterioration cause device malfunction in approximately half of patients by 10 years after implantation. Many patients desire to regain urinary continence and require revision surgery (RS), including device removal and simultaneous or delayed implantation. Patients for whom RS is considered should be examined physically and by interview for signs of infection. Urethral erosion should be assessed using cystoscopy. If there is infection or erosion, all devices should be removed first, and a new device should be implanted several months later. During the RS, after strong adhesion around the urethra, transcorporal cuff implantation is a safe choice. Device removal and simultaneous implantation can be performed in the absence of infection or erosion. If a long time has passed since device implantation, the entire device should be replaced due to device aging and deterioration; however, if the time is short, only the defective component need be replaced. Intraoperative assessment of urethral health is necessary for device removal and implantation. If the urethra is healthy, a new cuff can be placed in the same position as the old cuff was removed from; however, if the urethra is unhealthy, the cuff can be implanted in a more proximal/distal position, or a transcorporal cuff implant may be chosen. This article reviews the literature on diagnostic and treatment strategies for recurrent SUI in male patients with AUS and proposes a flowchart for AUS revision.
Ectoin attenuates cortisone‐induced skin issues by suppression GR signaling and the UVB‐induced overexpression of 11β‐HSD1
Authors: Xu Dailin , Wu Yue 
Published: September 2024

AbstractBackgroundAccelerated pace of modern work and lifestyles subject individuals to various external and psychological stressors, which, in turn, can trigger additional stress through visible signs of fatigue, hair loss, and obesity. As the primary stress hormone affecting skin health, cortisol connects to the glucocorticoid receptor (GR) to aggravate skin issues induced by stress. This activation depends on the expression of 11β‐hydroxysteroid dehydrogenase 1 (11β‐HSD1) in skin cells, which locally converts cortisone—produced by the central and peripheral hypothalamic‐pituitary‐adrenal axis—into its active form.MethodsOur study delves deeper into stress's adverse effects on the skin, including the disruption of keratinocyte structural proteins, the loss of basement membrane proteins, and the degradation of collagen.ResultsRemarkably, we discovered that Ectoin, an amino acid derivative obtained from halophilic bacteria, is capable of mitigating the inhibitory impacts of cortisone on the expression of cutaneous functional proteins, including involucrin, loricrin, laminin‐5, and claudin‐1. Moreover, Ectoin reduces the suppressive effect of stress on collagen and hyaluronic acid synthesis by impeding GR signal transduction. Additionally, Ectoin counterbalances the UVB‐induced overexpression of 11β‐HSD1, thereby diminishing the concentration of endogenous glucocorticoids.ConclusionOur findings illuminate the significant potential of Ectoin as a preventative agent against stress‐induced skin maladies.
Brain Microvascular Pericyte Pathology Linking Alzheimer's Disease to Diabetes
Authors: El‐Ghazawi Kareem , Eyo Ukpong B. , Peirce Shayn M. 
Published: September 2024

ABSTRACTThe brain microvasculature, which delivers oxygen and nutrients and forms a critical barrier protecting the central nervous system via capillaries, is deleteriously affected by both Alzheimer's disease (AD) and type 2 diabetes (T2D). T2D patients have an increased risk of developing AD, suggesting potentially related microvascular pathological mechanisms. Pericytes are an ideal cell type to study for functional links between AD and T2D. These specialized capillary‐enwrapping cells regulate capillary density, lumen diameter, and blood flow. Pericytes also maintain endothelial tight junctions to ensure blood–brain barrier integrity, modulation of immune cell extravasation, and clearance of toxins. Changes in these phenomena have been observed in both AD and T2D, implicating “pericyte pathology” as a common feature of AD and T2D. This review examines the mechanisms of AD and T2D from the perspective of the brain microvasculature, highlighting how pericyte pathology contributes to both diseases. Our review identifies voids in understanding how AD and T2D negatively impact the brain microvasculature and suggests future studies to examine the intersections of these diseases.
ZmCRK1 negatively regulates maize's response to drought stress by phosphorylating plasma membrane H+‐ATPase ZmMHA2
Authors: Liu Jinjie , Li Xi‐Dong , Jia Dongyun , Qi Liuran , Jing Rufan , Hao Jie , Wang Zhe , Cheng Jinkui , Chen Li‐Mei 
Published: September 2024

Summary

Drought severely affects crop growth and yields. Stomatal regulation plays an important role in plant response to drought stress. Light‐activated plasma membrane‐localized proton ATPase (PM H+‐ATPase) mainly promoted the stomatal opening. Abscisic acid (ABA) plays a dominant role in the stomatal closure during drought stress. It is not clear how PM H+‐ATPase is involved in the regulation of ABA‐induced stomatal closure.

We found that a CALCIUM‐DEPENDENT PROTEIN KINASE RELATED KINASE 1 (ZmCRK1), and its mutant zmcrk1 exhibited slow water loss in detached leaves, high‐survival rate after drought stress, and sensitivity to stomatal closure induced by ABA. The ZmCRK1 overexpression lines are opposite.

ZmCRK1 interacted with the maize PM H+‐ATPase ZmMHA2. ZmCRK1 phosphorylated ZmMHA2 at the Ser‐901 and inhibited its proton pump activity. ZmCRK1 overexpression lines and zmmha2 mutants had low H+‐ATPase activity, resulting in impaired ABA‐induced H+ efflux.

Taken together, our study indicates that ZmCRK1 negatively regulates maize drought stress response by inhibiting the activity of ZmMHA2. Reducing the expression level of ZmCRK1 has the potential to reduce yield losses under water deficiency.
The role of environmental tax in guiding global climate policies to mitigate climate changes in European region
Authors: Ha Le Thanh 
Published: September 2024

AbstractThe purpose of this study is to perform a practical inquiry into the influence of environmental tax laws on the execution of climate‐related financial policies. Our research will assess the effectiveness of environmental tax measures in 23 European countries from 2011 to 2020. The panel‐corrected standard error (PCSE) model and the feasible generalized least squares (FGLS) model are used in the empirical examination of the link between environmental tax laws and the implementation of climate‐related financial measures. This study is based on panel data with cross‐sectional dependence. The results of our estimation highlight the need to improve policy effectiveness by using all four ecological tax indicators. These include total environmental tax revenue, energy tax revenue, pollution and resource tax revenue, and transportation tax revenue. Furthermore, we provide actual evidence clarifying the process by which the implementation of environmental tax policies improves the efficacy of climate‐related financial policies in the short term as well as the long term. According to the findings, a third of environmental tax policy indicators have a long‐term effect on the implementation of climate‐related financial measures, with no short‐term effects seen. Our findings are critical for economists and policy‐makers who support the environmental tax as an effective tool to promote a country's climate policy implementations.
Uptake and Accumulation of Cobalt Is Mediated by OsNramp5 in Rice
Authors: Huang Hengliang , Yamaji Naoki , Huang Sheng , Ma Jian Feng 
Published: September 2024

ABSTRACTCobalt (Co) contamination in soils potentially affects human health through the food chain. Although rice (Oryza sativa) as a staple food is a major dietary source of human Co intake, it is poorly understood how Co is taken up by the roots and accumulated in rice grain. In this study, we physiologically characterized Co accumulation and identified the transporter for Co2+ uptake in rice. A dose‐dependent experiment showed that Co mainly accumulated in rice roots. Further analysis with LA‐ICP‐MS showed Co deposited in most tissue of the roots, including exodermis, endodermis and stele region. Co accumulation analysis using mutants defective in divalent cation uptake showed that Co2+ uptake in rice is mediated by the Mn2+/Cd2+/Pb2+ transporter OsNramp5, rather than OsIRT1 for Fe2+ and OsZIP9 for Zn2+. Knockout of OsNramp5 enhanced tolerance to Co toxicity. Heterologous expression of OsNramp5 showed transport activity for Co2+ in Saccharomyces cerevisiae. Co2+ uptake was inhibited by either Mn2+ or Cd2+ supply. At the reproductive stage, the Co concentration in the straw and grains of the OsNramp5 knockout lines was decreased by 41%–48% and 28%–36%, respectively, compared with that of the wild‐type rice. The expression level of OsNramp5 in the roots was not affected by Co2+. Taken together, our results indicate that OsNramp5 is a major transporter for Co2+ uptake in rice, which ultimately mediates Co accumulation in the grains.
Mapping Public Health Nursing competencies: A comparative document analysis of competency frameworks and practice standards in the USA and Ireland
Authors: Vickers Niamh , Green Chloe 
Published: September 2024

AbstractThe Public Health Nursing discipline plays a crucial role in promoting sustainable health services. The establishment of competency frameworks and practice standards pertaining to Public Health Nursing has emerged as a cornerstone for guiding practice, education, and research. This study aimed to identify contemporary Public Health Nursing competency frameworks and practice standards and establish a robust list of competency domains. This will inform a subsequent phase of this project that will conduct a review of recent scholarly literature to discern prevailing research trends and delineate strategic directives and research priorities for the discipline.A systematic search of three databases and a grey literature search was undertaken by incorporating keywords to identify existing Public Health Nursing‐specific competency frameworks and practice standards. Through screening and selection based on our inclusion criteria, three documents were analyzed. A comprehensive document analysis was conducted to generate a unified domain list and associated descriptors. Three competency‐based frameworks and practice standards emanating from two countries, the United States of America and the Republic of Ireland met the inclusion criteria. The document analysis identified 16 individual domains. There was consistent evidence of similarity across the three documents. There were minimal divergences featured within the frameworks which are discussed and compelling justifications for inclusion as universal domains are provided.This document analysis has generated a list of 16 common Public Health Nursing competency domains which will be utilized in phase two of this project as a foundational framework for the purpose of analyzing research trends, influencing research priorities, and enhancing the focal areas for future research agendas within the discipline.
Methodological approaches in developing and implementing digital health interventions amongst underserved women
Authors: Crawford Allison D. , Slavin Rocky , Tabar Maryam , Radhakrishnan Kavita , Wang Min , Estrada Ashlynn , McGrath Jacqueline M. 
Published: September 2024

AbstractBackgroundMinority populations are utilizing mobile health applications more frequently to access health information. One group that may benefit from using mHealth technology is underserved women, specifically those on community supervision.ObjectiveDiscuss methodological approaches for navigating digital health strategies to address underserved women's health disparities.Description of the innovative methodUsing an intersectional lens, we identified strategies for conducting research using digital health technology and artificial intelligence amongst the underserved, particularly those with community supervision.Description of its effectivenessWe explore (1) methodological approaches that combine traditional research methods with precision medicine, digital phenotyping, and ecological momentary assessment; (2) implications for artificial intelligence; and (3) ethical considerations with data collection, storage, and engagement.DiscussionResearchers must address gendered differences related to health, social, and economic disparities concurrently with an unwavering focus on the protection of human subjects when addressing the unique needs of underserved women while utilizing digital health methodologies.Public contributionWomen on community supervision in South Central Texas helped inform the design of JUN, the mHealth app we reported in the case exemplar. JUN is named after the Junonia shell, a native shell to South Texas, which means strength, power, and self‐sufficiency, like the participants in our preliminary studies.
Number nativism1
Authors: Clarke Sam 
Published: September 2024

AbstractNumber Nativism is the view that humans innately represent precise natural numbers. Despite a long and venerable history, it is often considered hopelessly out of touch with the empirical record. I argue that this is a mistake. After clarifying Number Nativism and distancing it from related conjectures, I distinguish three arguments which have been seen to refute the view. I argue that, while popular, two of these arguments miss the mark, and fail to place pressure on Number Nativism. Meanwhile, a third argument is best construed as a challenge: rather than refuting Number Nativism, it challenges its proponents to provide positive evidence for their thesis and show that this can be squared with apparent counterevidence. In response, I introduce psycholinguistic work on The Tolerance Principle (not yet considered in this context), propose that it is hard to make sense of without positing precise and innate representations of natural numbers, and argue that there is no obvious reason why these innate representations couldn't serve as a basis for mature numeric conception.
Effect of different weight initialization strategies on transfer learning for plant disease detection
Authors: Sinanc Terzi Duygu 
Published: September 2024

AbstractThe weight initialization technique for transfer learning refers to the practice of using pretrained models that can be modified to solve new problems, instead of starting the training process from scratch. In this study, six different transfer learning weight initialization strategies were proposed for plant disease detection: scratch (i.e., random initialization), pretrained model on cross‐domain (ImageNet), model trained on related domain (ISIC 2019), model trained on related domain (ISIC 2019) with cross‐domain (ImageNet) weights, model trained on same domain (PlantVillage), and model trained on same domain (PlantVillage) with cross‐domain weights (ImageNet). Weights from each strategy were transferred to a target dataset (Plant Pathology 2021). These strategies were implemented using eight deep learning architectures. It was observed that transferring from any strategy led to an average acceleration of convergence ranging from 33.88% to 73.16% in mean loss and an improvement of 8.72%–42.12% in mean F1‐score compared to the scratch strategy. Moreover, although smaller and less comprehensive than ImageNet, transferring information from the same domain or related domain proved to be competitive compared to transferring from ImageNet. This indicates that ImageNet, which is widely favoured in the literature, may not necessarily represent the most optimal transfer source for the given context. In addition, to identify which strategies have significant differences, a post hoc analysis using Tukey's HSD test was conducted. Finally, the classifications made by the proposed models were visualized using Grad‐CAM to provide a qualitative understanding of how different weight initialization strategies affect the focus areas of the models.
Does cognitive control mediate the relationship between peer presence and adolescent risk‐taking? An ERP study
Authors: Guo Mingyu , Lu Yafei , Zhai Ruonan , Tian Lumei 
Published: September 2024

AbstractPeer presence influences risk‐taking behavior, particularly in adolescence. Based on the dual system model, this event‐related potential study examined whether and how the presence of a peer displayed a preference for risky behavior would increase adolescents' risk‐taking by disrupting their cognitive control processes in either emotional or non‐emotional contexts. A sample of 106 adolescents (17–19 years of age) completed two Stoop tasks and a Balloon Analog Risk Task under three peer presence conditions. Results revealed that compared to other conditions, the presence of a risk‐averse peer caused adolescents to make safer decisions through improving their conflict monitoring (more negative N200‐diff), whereas a risk‐preference peer's presence led adolescents to more risky decisions through disrupting their conflict resolution (more positive N450‐diff) but they were only observed on the Emotional Stroop task. These findings suggest that different peer presence contexts could increase or decrease adolescents' risk‐taking behaviors by influencing their cognitive control under an emotional context rather than in a non‐emotional context.
Comparison of facial skin ageing in healthy Asian and Caucasian females quantified by in vivo line‐field confocal optical coherence tomography 3D imaging
Authors: Ali Assi , Colombe Lopez , Mélanie Pedrazzani , Agnes Pignol‐Lavoix , Meryem Nili , Samuel Ralambondrainy , Guénolé Grignon , Jean‐Hubert Cauchard , Rodolphe Korichi , Franck Bonnier 
Published: September 2024

AbstractBackgroundQuantitative biomarkers of facial skin aging were investigated in 109 healthy Asian female volunteers, aged 20 to 70 years.Materials and MethodsIn vivo 3D Line‐field Confocal Optical Coherence Tomography (LC‐OCT) imaging, enhanced by Artificial Intelligence (AI)‐based quantification algorithms, was utilized to compute various metrics, including stratum corneum thickness (SC), viable epidermal (VE) thickness, and Dermal‐Epidermal Junction (DEJ) undulation along with cellular metrics for the temple, cheekbone, and mandible.ResultsComparison with data from a cohort of healthy Caucasian volunteers revealed similarities in the variations of stratum corneum and viable epidermis layers, as well as cellular shape and size with age in both ethnic groups. However, specific findings emerged, such as larger, more heterogeneous nuclei in both layers, demonstrated by an increase in nuclei volume and their standard deviation, and increased network atypia, all showing significant age‐related variations. Caucasian females exhibited a flatter and more homogeneous epidermis, evidenced by a decreased standard deviation of the number of layers, and a less dense cellular network with fewer cells per layer, indicated by a decrease in cell surface density.ConclusionEthnicity‐wise comparisons highlighted distinct biological features specific to each population. Asian individuals showed significantly higher DEJ undulation, higher compactness, and lower cell network atypia compared to their Caucasian counterparts across age groups. Differences in stratum corneum and viable epidermal thickness on the cheekbone were also significant. LC‐OCT 3D imaging provides valuable insights into the aging process in different populations and underscores inherent biological differences between Caucasian and Asian female volunteers.
Investigating the efficacy of Endolift laser and Nanofat as a combination therapy for horizontal neck lines compared to Nanofat autologous alone
Authors: Nilforoushzadeh Mohammad Ali , Rafiee Shohreh , Heidari‐Kharaji Maryam , Fakhim Tannaz , Nobari Niloufar Najar , Shahverdi Mohammadhasan , Lotfi Zahra , Zare Sona , Torkamaniha Elham , Alavi Shiva 
Published: September 2024

AbstractBackgroundThe emergence of horizontal neck wrinkles is increasingly becoming a focal point for both cosmetic professionals and clients. Various treatment approaches must be considered to address this issue effectively, owing to its diverse underlying causes. The study explores the potential of utilizing the Endolift laser in conjunction with nanofat injection as a viable treatment option.MethodsTwenty patients with horizontal neck wrinkles involved in the study. Ten patients underwent treatment with a combination of Endolift laser and nanofat injection and 10 patients treated with nanofat injection alone. The participants were monitored for 6 months post‐treatment. Biometric measurements were utilized to assess outcomes, including changes in volume, depth, and area of the wrinkles, skin elasticity, as well as the diameter and density of the epidermis and dermis in the treated area. Skin improvement was evaluated by two independent dermatologists, who compared before and after photos in a blinded manner. Patient satisfaction levels were also documented.ResultsThe Visioface analysis showed a notable decrease in neck wrinkle depth and area in both groups. However, the group receiving the combination treatment of Endolift laser and nanofat exhibited a significantly greater improvement compared to the group treated with nanofat alone. Skin ultrasonography results demonstrated an increase in thickness and density of the dermis and epidermis in both groups. Particularly, the group treated with Endolift laser‐nanofat displayed significant enhancements in dermis and epidermis density and thickness when contrasted with the nanofat‐only group. Analysis with Cutometer revealed a marked enhancement in skin elasticity in the Endolift‐nanofat treated group in comparison to the nanofat‐only treated group. Furthermore, in the Endolift‐nanofat treated group, a substantial majority (90%) of patients exhibited improvement. Patient evaluations highlighted significant distinctions between the two groups, with 95% of patients in the Endolift‐nanofat treated group demonstrating enhancement.ConclusionBoth methods notably enhance horizontal neck wrinkles; nevertheless, the combination of endolift laser and nanofat seems to be more efficient for treating horizontal neck wrinkles.