bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Influencer Marketing dan Trust terhadap Repurchase Intention Produk Skin Care Bening’s
Authors: Naibaho Krismanto Erick Tobush 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh influencer marketing dan trust terhadap repurchase intention pada produk skin care Bening’s. Bening’s menghadirkan produk skin care untuk perawatan wajah. Penjualan produk Bening’s dilakukan dengan memanfaatkan kepopuleran para influencer. Penelitian ini menggunakan variabel independen yaitu influencer marketing dan trust. Variabel dependennya adalah repurchase intention. Teknik pengambilan sampel menggunakan purposive sampling. Populasi dalam penelitian ini adalah konsumen Bening’s di Kota Medan yang pernah melakukan pembelian minimal dua kali. Jumlah sampel dalam penelitian ini sebanyak 100 orang. Analisis data yang digunakan adalah analisis regresi linear berganda. Hasil penelitian ini menunjukkan bahwa influencer marketing berpengaruh negatif dan tidak signifikan terhadap repurchase intention pada produk skin care Bening’s sedangkan trust berpengaruh positif dan signifikan terhadap repurchase intention pada produk skin care Bening’s di Kota Medan.
Puentes literarios: el mundo editorial mexicano y su vínculo con España
Authors: Prats Marí Antonio , Rodríguez de Segovia Messtorff Itziar 
Published: September 2024

El presente ensayo busca proporcionar una visión integral del sector editorial mexicano, al tiempo que resalta la importancia de sus vínculos con España, contribuyendo a un entendimiento más profundo de la dinámica cultural entre ambos países. Para ello, se lleva a cabo una revisión del panorama editorial mexicano actual, utilizando la bibliografía existente.
En primer lugar, se examina el estado actual del sector editorial en México, destacando su evolución, sus desafíos y sus logros recientes. Se analizan las cifras de ventas, la diversidad de publicaciones y la participación en eventos internacionales como la Feria Internacional del Libro de Guadalajara (FIL). También se exploran los principales actores de este mercado en el contexto mexicano, desde grandes editoriales hasta independientes, y su contribución al enriquecimiento cultural del país. Posteriormente, se estudia el vínculo entre México y España en el ámbito editorial. Este análisis permite identificar las sinergias que han emergido de esta relación, destacando cómo han facilitado la circulación de obras literarias y el enriquecimiento cultural mutuo.
Peran Pemerintah Dalam Upaya Menanggulangi Banjir Yang Terjadi Di Kawasan Cibaduyut
Authors: Firdaus Fahrizal Rahman , Ismail Rangga , Simanjuntak Sintha Apriliani , Ginanjar Sunandie Eko 
Published: September 2024

Indonesia merupakan negara yang rawan akan bencana baik bencana alam maupun non alam. Bencana merupakan sebuah peristiwa yang mengancam dan mengganggu kehidupan dan penghidupan Masyarakat. Banjir merupakan luapan air yang tidak dapat ditampung sungai, banjir juga merupakan sebuah Bencana karena mengganggu aktivitas yang masyarakat. Kota Bandung memiliki resiko rentan bencana banjir Yang tegolong tinggi. Metode pelaksanaan menggunakan Kualitatif Dengan Desain Penelitian Studi Deskriptif Oleh karenanya perlu dilakukan upaya untuk menanggulangi bencana banjir tersebut. Salah satu daerah yang akan di bahas yaitu kawasan cibaduyut dimana daerah tersebut sering terjadinya kebanjiran.
STRATEGI PENCITRAAN PERUSAHAAN MELALUI PROGRAM CORPORATE SOCIAL RESPONSIBILITY (STUDI KASUS KEGIATAN MINI NURSERY PROGRAM PT LIPPO CIKARANG, TBK)
Authors: Wahyuni Devi , Yuniarti Tatik 
Published: September 2024

On present the competitive rivalry era, a company is required to establish apositive corporate image on consumers. This positive image will implications on the level of sales and revenue, of company more ever customers satisfaction for customers. Strategic Corporate Social Responsibility (CSR) as a this concept in which PT Lippo Cikarang, Inc. Integrates social and environmental concept implemented by Mini Nursery Program.
The purpose of this study to find out how the strategy of corporate social responsibility (CSR) of public relations PT Lippo Cikarang, Inc. in the nursery program (mini-nursery program), to analyze the role of public relations, analyze the relevant parties, and analyzed the mini-nursery program as the flagship program company. Strategies of CSR by PT Lippo Cikarang, Inc. used a model of planning John M. King is Rope (Research, Objectives, Programs, and Evaluation) on which the initial planning of the CSR activities undertaken.
Aplications CSR around Mini Nursery Program activities are conducted with 11 schools located around PT Lippo Cikarang, Inc. product positive image to the increasis in corporate investment as a developer which cares about the environment, it is proved by along the median line which includes the streets and cluster housing in the region looks green
A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema
Authors: Sexton Dan , Faucette Ryan , Rivera-Hernandez Melody , Kenniston Jon A. , Papaioannou Nikolaos , Cosic Janja , Kopacz Kris , Salmon Gary , Beauchemin Chantal , Juethner Salomé , Yeung Dave 
Published: September 2024

BackgroundCleaved high-molecular-weight kininogen (HKa) is a disease state biomarker of kallikrein-kinin system (KKS) activation in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH), the endogenous inhibitor of plasma kallikrein (PKa).ObjectiveDevelop an HKa-specific enzyme-linked immunosorbent assay (ELISA) to monitor KKS activation in the plasma of HAE-C1INH patients.MethodsA novel HKa-specific antibody was discovered by antibody phage display and used as a capture reagent to develop an HKa-specific ELISA.ResultsSpecific HKa detection following KKS activation was observed in plasma from healthy controls but not in prekallikrein-, high-molecular-weight kininogen-, or coagulation factor XII (FXII)-deficient plasma. HKa levels in plasma collected from HAE-C1INH patients in a disease quiescent state were higher than in plasma from healthy controls and increased further in HAE-C1INH plasma collected during an angioedema attack. The specificity of the assay for PKa-mediated HKa generation in minimally diluted plasma activated with exogenous FXIIa was demonstrated using a specific monoclonal antibody inhibitor (lanadelumab, IC50 = 0.044 µM).ConclusionsAn ELISA was developed for the specific and quantitative detection of HKa in human plasma to support HAE-C1INH drug development. Improved quantification of the HKa biomarker may facilitate further pathophysiologic insight into HAE-C1INH and other diseases mediated by a dysregulated KKS and may enable the design of highly potent inhibitors targeting this pathway.
Engineering bacterial theranostics: from logic gates to in vivo applications
Authors: Armstrong Angus , Isalan Mark 
Published: September 2024

Over the past 2 decades, rapid advances in synthetic biology have enabled the design of increasingly intricate and biologically relevant systems with broad applications in healthcare. A growing area of interest is in designing bacteria that sense and respond to endogenous disease-associated signals, creating engineered theranostics that function as disease surveyors for human health. In particular, engineered cells hold potential in facilitating greatly enhanced temporal and spatial control over the release of a range of therapeutics. Such systems are particularly useful for targeting challenging, under-drugged disease targets in a more nuanced manner than is currently possible. This review provides an overview of the recent advances in the design, delivery, and dynamics of bacterial theranostics to enable safe, robust, and genetically tractable therapies to treat disease. It outlines the primary challenges in theranostic clinical translation, proposes strategies to overcome these issues, and explores promising future avenues for the field.
Exploring Burkholderia pseudomallei-specific bacteriophages: overcoming O-antigen specificity and adaptive mutation in phage tail fiber
Authors: Khrongsee Pacharapong , Kaewrakmuk Jedsada , Alami-Rose Mariam , Subramaniam Kuttichantran , Waltzek Thomas B. , Schweizer Herbert P. , Tuanyok Apichai 
Published: September 2024

IntroductionBurkholderia pseudomallei, a Gram-negative bacterium inhabiting soil and fresh water, is the causative agent of melioidosis, a formidable disease in the tropics. The emergence of antibiotic resistance and the extended duration of treatment, up to 20 weeks, have posed significant challenges in combatting melioidosis. As an alternative approach, bacteriophage therapy is being explored.MethodsTo identify the most promising bacteriophage for future therapeutic applications, we designed a screening process to address the barrier of phage specificity due to the O-antigen receptor diversity. By using two biosafe strains, Bp82 (O-antigen type A) and 576mn (O-antigen type B), to represent the major serotype A and B, we screened 145 phage samples collected from soil and water in southern Thailand.ResultsTen of them demonstrated the ability to overcome differences in O-antigen types, yielding positive plaques formed on culture of both bacterial strains. Subsequently, we isolated 22 bacteriophages from these samples, one was adaptively mutated during the screening process, named ΦPK23V1, which had the ability to infect up to 83.3% (115/138) of tested B. pseudomallei strains, spanning both serogroups. Employing a panel of surface polysaccharide antigen mutant strains, we explored the role of capsular polysaccharide (CPS) and O-antigens as essential components for phage infection. All isolated phages were classified into the P2-like myophage group. Additionally, our research revealed a point mutation in the phage tail fiber gene (gpH), expanding the host range of ΦPK23V1, even in the absence of CPS and O-antigens.DiscussionHowever, it was evident that ΦPK23V1 is a lysogenic phage, which cannot be readily applied for therapeutic use. This discovery sheds light on the receptor binding domain of P2-like bacteriophages in B. pseudomallei. Collectively, our study has identified bacteriophages with a broad host range within B. pseudomallei strains, enhancing our understanding of phage–host interactions and offering insights into the role of the phage tail fiber gene in host cell entry.
Intratumoral and fecal microbiota reveals microbial markers associated with gastric carcinogenesis
Authors: Wang Yiwen , Wang Yue , Han Wenjie , Han Mengzhen , Liu Xiaolin , Dai Jianying , Dong Yuesheng , Sun Tao , Xu Junnan 
Published: September 2024

BackgroundThe relationship between dysbiosis of the gastrointestinal microbiota and gastric cancer (GC) has been extensively studied. However, microbiota alterations in GC patients vary widely across studies, and reproducible diagnostic biomarkers for early GC are still lacking in multiple populations. Thus, this study aimed to characterize the gastrointestinal microbial communities involved in gastric carcinogenesis through a meta-analysis of multiple published and open datasets.MethodsWe analyzed 16S rRNA sequencing data from 1,642 gastric biopsy samples and 394 stool samples across 11 independent studies. VSEARCH, QIIME and R packages such as vegan, phyloseq, cooccur, and random forest were used for data processing and analysis. PICRUSt software was employed to predict functions.ResultsThe α-diversity results indicated significant differences in the intratumoral microbiota of cancer patients compared to non-cancer patients, while no significant differences were observed in the fecal microbiota. Network analysis showed that the positive correlation with GC-enriched bacteria increased, and the positive correlation with GC-depleted bacteria decreased compared to healthy individuals. Functional analyses indicated that pathways related to carbohydrate metabolism were significantly enriched in GC, while biosynthesis of unsaturated fatty acids was diminished. Additionally, we investigated non-Helicobacter pylori (HP) commensals, which are crucial in both HP-negative and HP-positive GC. Random forest models, constructed using specific taxa associated with GC identified from the LEfSe analysis, revealed that the combination of Lactobacillus and Streptococcus included alone could effectively discriminate between GC patients and healthy individuals in fecal samples (area under the curve (AUC) = 0.7949). This finding was also validated in an independent cohort (AUC = 0.7712).ConclusionsThis study examined the intratumoral and fecal microbiota of GC patients from a dual microecological perspective and identified Lactobacillus, Streptococcus, Roseburia, Faecalibacterium and Phascolarctobacterium as intratumoral and intestinal-specific co-differential bacteria. Furthermore, it confirmed the validity of the combination of Lactobacillus and Streptococcus as GC-specific microbial markers across multiple populations, which may aid in the early non-invasive diagnosis of GC.
SNX27:Retromer:ESCPE-1-mediated early endosomal tubulation impacts cytomegalovirus replication
Authors: Štimac Igor , Marcelić Marina , Radić Barbara , Viduka Ivona , Blagojević Zagorac Gordana , Lukanović Jurić Silvija , Rožmanić Carmen , Messerle Martin , Brizić Ilija , Lučin Pero , Mahmutefendić Lučin Hana 
Published: September 2024

IntroductionCytomegaloviruses (CMVs) extensively reorganize the membrane system of the cell and establish a new structure as large as the cell nucleus called the assembly compartment (AC). Our previous studies on murine CMV (MCMV)-infected fibroblasts indicated that the inner part of the AC contains rearranged early endosomes, recycling endosomes, endosomal recycling compartments and trans-Golgi membrane structures that are extensively tubulated, including the expansion and retention of tubular Rab10 elements. An essential process that initiates Rab10-associated tubulation is cargo sorting and retrieval mediated by SNX27, Retromer, and ESCPE-1 (endosomal SNX-BAR sorting complex for promoting exit 1) complexes.ObjectiveThe aim of this study was to investigate the role of SNX27:Retromer:ESCPE-1 complexes in the biogenesis of pre-AC in MCMV-infected cells and subsequently their role in secondary envelopment and release of infectious virions.ResultsHere we show that SNX27:Retromer:ESCPE1-mediated tubulation is essential for the establishment of a Rab10-decorated subset of membranes within the pre-AC, a function that requires an intact F3 subdomain of the SNX27 FERM domain. Suppression of SNX27-mediated functions resulted in an almost tenfold decrease in the release of infectious virions. However, these effects cannot be directly linked to the contribution of SNX27:Retromer:ESCPE-1-dependent tubulation to the secondary envelopment, as suppression of these components, including the F3-FERM domain, led to a decrease in MCMV protein expression and inhibited the progression of the replication cycle.ConclusionThis study demonstrates a novel and important function of membrane tubulation within the pre-AC associated with the control of viral protein expression.
Revealing the association between East Asian oral microbiome and colorectal cancer through Mendelian randomization and multi-omics analysis
Authors: Gu Yuheng , Jiang Lai , Shui Min , Luo Honghao , Zhou Xuancheng , Zhang Shengke , Jiang Chenglu , Huang Jinbang , Chen Haiqing , Tang Jingyi , Fu Yiping , Luo Huiyan , Yang Guanhu , Xu Ke , Chi Hao , Liu Jie , Huang Shangke 
Published: September 2024

BackgroundColorectal cancer (CRC) poses a global health threat, with the oral microbiome increasingly implicated in its pathogenesis. This study leverages Mendelian Randomization (MR) to explore causal links between oral microbiota and CRC using data from the China National GeneBank and Biobank Japan. By integrating multi-omics approaches, we aim to uncover mechanisms by which the microbiome influences cellular metabolism and cancer development.MethodsWe analyzed microbiome profiles from 2017 tongue and 1915 saliva samples, and GWAS data for 6692 CRC cases and 27178 controls. Significant bacterial taxa were identified via MR analysis. Single-cell RNA sequencing and enrichment analyses elucidated underlying pathways, and drug predictions identified potential therapeutics.ResultsMR identified 19 bacterial taxa significantly associated with CRC. Protective effects were observed in taxa like RUG343 and Streptococcus_umgs_2425, while HOT-345_umgs_976 and W5053_sp000467935_mgs_712 increased CRC risk. Single-cell RNA sequencing revealed key pathways, including JAK-STAT signaling and tyrosine metabolism. Drug prediction highlighted potential therapeutics like Menadione Sodium Bisulfite and Raloxifene.ConclusionThis study establishes the critical role of the oral microbiome in colorectal cancer development, identifying specific microbial taxa linked to CRC risk. Single-cell RNA sequencing and drug prediction analyses further elucidate key pathways and potential therapeutics, providing novel insights and personalized treatment strategies for CRC.
Coupling of anticipation and breathing in expert flute performance: the influence of musical structure and practice
Authors: Cara Michel A. , Mitrovic Divna 
Published: September 2024

IntroductionIn this study, we examined the cognitive processes and physiological responses involved in learning a flute piece by the composer Charles Koechlin among musicians of different expertise levels. Participants performed the piece four times consecutively, with a 2-min practice interval between the first and the second trial.MethodsUsing data obtained from an eye tracker, respiratory sensors, and an audio recorder we assessed short-term improvement and the effect of musical structure and practice on key variables identified through a multivariate approach: eye-hand span (EHS), time index of EHS, thoracic and abdominal amplitude (breathing patterns) and pupil dilation.ResultsThe analysis revealed two main dimensions: one associated with EHS; and the other with embodied responses to music, closely linked to breathing patterns and pupil dilation. We found an effect of musical structure on all the variables studied, while the EHS improved with practice. Expert musicians demonstrated enhanced EHS and adapted their breathing patterns more effectively to the music's structure.DiscussionThese insights support the hypothesis of a coupling between anticipation and breathing, emphasizing the role of perceptual and embodied components in music reading and learning.
A comparative study of the clinical benefits of rivaroxaban and dabigatran in patients with nonvalvular atrial fibrillation with high bleeding risk
Authors: Liu Penghui 
Published: September 2024

ObjectiveRivaroxaban and dabigatran are approved to reduce the risk of stroke in patients with nonvalvular atrial fibrillation (NVAF). However, the clinical benefits of rivaroxaban and dabigatran in people with high bleeding risk are unclear.MethodsA retrospective study was conducted on NVAF patients admitted to the First Affiliated Hospital of Zhengzhou University from May 31, 2016 to May 31, 2019. These patients had a high risk of bleeding and were taking at least one study medication. The aim of the study was to evaluate clinical benefits by comparing the efficacy and safety risks of these two medicationsResultsA total of 1,301 patients with high bleeding risk were enrolled, including 787 patients in the rivaroxaban group and 514 patients in the dabigatran group. Results of the primary efficacy benefit endpoint were obtained from 104 patients (13.21%) in the rivaroxaban group and 81 (15.76%) patients in the dabigatran group [hazard ratio (HR): 0.860; 95% confidence interval (CI): 0.637–1.162; P = 0.327], this indicates that there was no significant difference between dabigatran and rivaroxaban in preventing stroke and systemic embolism in patients with high bleeding risk NVAF. The principal safety end points were observed in 49 (6.23%) patients in the rivaroxaban group and in 36 (7.00%) patients in the dabigatran group (HR: 0.801 in the rivaroxaban group; 95% CI: 0.512–1.255; P = 0.333), this indicates that there was no a significant difference in reducing fatal bleeding and critical organ bleeding. With respect to secondary efficacy and benefit endpoints, 28 (3.56%) patients in the rivaroxaban group and 26 (5.06%) patients in the dabigatran group died, with an HR of 0.725 (95% CI: 0.425–1.238; P = 0.239); 32 (4.07%) patients in the rivaroxaban group; and 31 (6.03%) patients in the dabigatran group had myocardial infarction (MI), with an HR of 0.668 (95% CI: 0.405–1.102, P = 0.114) in the rivaroxaban group, this indicates that there was no significant difference between dabigatran and rivaroxaban in preventing all-cause death and MI.ConclusionsIn NVAF patients with high bleeding risk, there was no significant difference between dabigatran and rivaroxaban in preventing stroke and systemic embolism. There was also no significant difference between dabigatran and rivaroxaban in reducing fatal and critical organ bleeding.
Clinical Trial RegistrationChinese Clinical Trials Registry, identifier ChiCTR2100052454.
Concomitant ablation for non-paroxysmal atrial fibrillation: combined energy versus cryoablation alone
Authors: Tsaroev Bashir , Sharifulin Ravil , Afanasyev Alexander , Khrushchev Sergey , Murtazaliev Murtazali , Lovtsova Darya , Kashapov Robert , Ruzankin Pavel , Mustaev Muslim , Bogachev-Prokophiev Alexander 
Published: September 2024

BackgroundSurgical ablation of atrial fibrillation has been the most efficient treatment for atrial fibrillation (AF). Combined energy (CE) ablation and cryoablation alone (CA) are the most common energy modes used for ablation, however, comparative data is lacking.ObjectivesTo compare the efficacy of CE ablation with CA in the setting of concomitant biatrial ablation for non-paroxysmal AF.MethodsA retrospective analysis of 453 patients with non-paroxysmal AF undergone concomitant biatrial ablation from November 2007 to December 2022 during elective cardiac surgery using either combined bipolar radiofrequency with cryoenergy or cryoenergy alone was performed. Propensity score matching was conducted to balance the covariates in the groups.ResultsThere were 157 patients per group after matching. CE ablation was associated with lower odds of atrial tachyarrhythmia recurrence (OR = 0.13, 95% CI 0.02–0.91, p = 0.040), a significantly lower rate of hospital readmissions due to rhythm disruption (HR = 0.34, 95% CI 0.18–0.65, p &lt; 0.001), and lower cumulative incidence of stroke (SHR = 0.38, 95% CI 0.15–0.97, p = 0.043). No significant difference in permanent pacemaker implantation was observed between the two groups.ConclusionsIn the setting of concomitant biatrial ablation for non-paroxysmal AF, combined bipolar radiofrequency and cryoablation appear to be a superior treatment modality compared to cryoablation alone in achieving long-term freedom from atrial arrhythmias, in reducing arrhythmia-related hospital readmissions and ischemic strokes.