bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiotherapy Combined With Zoledronic Acid for Fibrous Dysplasia With a Central Giant Cell Granuloma: A Case Report
Authors: Xu Ying , Gao Kuanke , Liu Jing , Yang Defu , Wu Tong , Zhang Haibo , Yan Ying , Lv Dongyang 
Published: October 2024

ABSTRACTBackgroundGiant cell reparative granulomas are nonneoplastic, benign lesions that can expand and dissolve bone. Fibrous dysplasia is a benign condition in which normal bone tissue is replaced by abnormally proliferating immature reticular bone and fibrous tissue. The combination of giant cell reparative granuloma and fibrous dysplasia is extremely rare and can pose diagnostic and therapeutic challenges because of the complexity of clinical presentation.Case PresentationWe here present a patient who had a combination of fibrous dysplasia of bone and a giant cell reparative granuloma. An elderly male was admitted to the hospital with a blood‐streaked nasal discharge, blurry vision in his right eye, and an enlarged mass under the chin. A CT scan revealed that the lesion had infiltrated the head and face extensively, including the right maxillary sinus, sieve sinus, and the right nasal cavity, contraindicating surgery. The patient received a total dose of 30 Gy of 6 MV x‐ray radiotherapy delivered through helical tomotherapy over 15 sessions, with a single dose of 2 Gy being administered five times a week. Concurrently, The dose is 4 mg of zoledronic acid administered intravenously once every 21 days. After treatment, the patient's nasal congestion was significantly relieved, the vision of the right eye improved, and the mandibular lesion was significantly reduced.ConclusionsTreatment with radiotherapy combined with zoledronic acid for our patient's inoperable osteolytic giant cell reparative granuloma adjacent to vital nerves and blood vessels was extremely effective and safe. This case report provides a reference for the management of this rare combination.
NB‐IoT: Analytical Perspective of IP Data Delivery Variants
Authors: Mandal Priyatosh 
Published: October 2024

ABSTRACTNarrowband Internet of Things (NB‐IoT) is generally used for transmission of IP data and Non IP data from sensing device to a designated IoT server. Further, the designated server takes decision and accordingly send data to necessary devices for some designated activity. Two communication architectures such as control plane based and user plane based IP data deliveries are possible. In this work, we analytically find the delay to send NB‐IoT IP data considering control plane as well as user plane of LTE‐A network. Further, we compare the delay considering these two variants of data deliveries. Comparison results show that delay of the control plane based data delivery can be more than the delay of user plane based data delivery.
Restrictions on pharmacist dispensing of mifepristone remain a hard pill to swallow
Authors: Boyden Kelli , Hatton Randy C. , Lynch Catherine M. , Brushwood David B. 
Published: October 2024

AbstractThis analysis explores the basis for the US Food and Drug Administration (FDA) requiring a Risk Evaluation and Mitigation Strategy (REMS) for mifepristone for the termination of intrauterine pregnancy. Controversies surround mifepristone and its REMS. The safety and efficacy of mifepristone are briefly reviewed with respect to FDA's actions. It is difficult to justify the continued requirement for a REMS for mifepristone by applying the regulatory framework and considering mifepristone's safety record. Drugs with higher risks are on the US market without an FDA‐mandated REMS. Canada removed all restrictions on the use of mifepristone for abortion, which has not resulted in patient safety concerns. All pharmacists should be permitted to dispense mifepristone. The continued requirement for a mifepristone REMS in the US appears to be based more on politics rather than evidence.
Regioselective Synthesis of Imidazo[4,5‐e][1,3]Thiazino[3,2‐b][1,2,4]Triazines as New Heterocyclic System Derivatives
Authors: Izmest'ev Alexei N. , Baranov Vladimir V. , Kolotyrkina Natalya G. , Kravchenko Angelina N. , Gazieva Galina A. 
Published: October 2024

ABSTRACTA series of new 4a,7a‐diarylperhydroimidazo[4,5‐e][1,2,4]triazine‐3‐thiones were synthesized from 4,5‐diaryl‐4,5‐dihydroxyimidazolidin‐2‐ones and thiosemicarbazide in high yields, and their interaction with ethyl phenylpropiolate was studied. An effective method for the regioselective synthesis of imidazo[4,5‐e][1,3]thiazino[3,2‐b][1,2,4]triazines as new heterocycic system derivatives was proposed based on the reaction of aforementioned imidazotriazinethiones with ethyl phenylpropiolate in the presence of MeONa in methanol. The reaction is initiated by a Michael‐type addition of the imidazotriazinethiones to the triple bond of ethyl phenylpropiolate followed by intramolecular cyclization.
Inclusion of Veterans Health Administration hospitals in Centers for Medicare & Medicaid Services Overall Hospital Quality Star Ratings
Authors: Bagshaw Kyle , Gettel Cameron J. , Qin Li , Lin Zhenqiu , Suter Lisa G. , Rothenberg Eve , Omotosho Prince , Duseja Reena , Krabacher James , Schreiber Michelle , Nakashima Tyson , Myers Raquel , Venkatesh Arjun K. 
Published: October 2024

AbstractBackground/ObjectiveThe Centers for Medicare & Medicaid Services (CMS) Overall Hospital Quality Star Rating, established in 2016, is a summary of publicly available quality information for acute care hospitals. In July 2023, Veterans Health Administration (VHA) hospitals became eligible to receive a CMS Overall Hospital Quality Star Rating for the first time. Our objective was to compare performance in quality ratings among VHA and non‐VHA hospitals.MethodsWe used the hospital quality measure scores posted to Care Compare on Medicare.gov as of January 2023 as our primary data set. We conducted a pair of analyses to characterize the performance of VHA hospitals compared to non‐VHA hospitals: an overall analysis including all rated hospitals, and a matched analysis in which only a single nearby hospital was included for each VHA hospital.ResultsOf the 4518 non‐VHA hospitals, 2962 (65.6%) received a Star Rating, compared to 114 (84%) of 136 VHA hospitals. VHA hospitals tended to receive higher ratings overall (one‐star: 8%; two‐star: 11%; three‐star: 14%; four‐star: 35%; five‐star: 32%) than non‐VHA (one‐star: 8%; two‐star: 22%; three‐star: 29%; four‐star: 26%; five‐star: 15%). A similar pattern was observed in the matched analysis.ConclusionsVHA hospitals tended to perform better on the Overall Star Rating compared to non‐VHA hospitals, as evidenced by being more likely to receive a four‐ or five‐star rating. The eligibility of VHA hospitals to receive an Overall Star Rating signifies an important addition to the program that will allow Veterans to make more informed healthcare decisions.
Embryonic and Fetal Heart Development Before 12 Weeks of Gestation
Authors: Hata Toshiyuki , Konishi Miyu , Koyanagi Aya , Miyagi Yasunari , Miyake Takahito 
Published: October 2024

ObjectiveTo assess embryonic and fetal cardiac growth and development using transvaginal 2‐dimensional sonography before 12 weeks of gestation.MethodsTransvaginal scans for first‐trimester dating were performed for 131 normal fetuses at 8–11 + 6 weeks of gestation. The basal‐apical length (BAL), transverse length (TL), cardiac circumference (ECC), embryonic cardiac area (ECA), global sphericity index (GSI), and cardio‐thoracic area ratio (CTAR) were able to be obtained in 105 normal embryos and fetuses.ResultsNomograms for several cardiac parameters including BAL, TL, ECC, ECA, GSI, and CTAR were constructed. BAL, TL, ECC, and ECA increased curvilinearly with advancing gestation (R2 = 0.97406, 0.980396, 0.978359, and 0.920705, respectively, P < .001). GSI (mean, 1.14; SD, 0.10) and CTAR (mean, 15.7%; SD, 3.3%) values were constant at 8–11 + 6 weeks of gestation. There were significant curvilinear correlations between BAL, TL, ECC, and ECA, and crown‐rump length (CRL) (R2 = 0.975976, 0.983482, 0.980673, and 0.929936, respectively, P < .001). GSI and CTAR values were not changed with the increase of CRL during this period.ConclusionOur results provide nomograms for several cardiac parameters which may improve the understanding of embryonic and fetal cardiac growth and development prior to 12 weeks of gestation.
Innovative Tillage Practices to Establish Productive and Sustainable Forage Production Systems in Degraded Alfalfa Pastures in Semiarid Regions
Authors: Wang Bin , Deng Jianqiang , Wang Tengfei , Hu Haiying , Usman Samaila , Lan Jian 
Published: October 2024

ABSTRACTTillage management practices play a critical role in maintaining sustainable forage production systems in degraded alfalfa (Medicago sativa L.) pastures. However, climate change leads to the precipitation exhibits greater variability, the impacts of tillage practices on alfalfa productivity and forage quality as well as the relationships between water consumption and soil properties remain poorly understood. The field trial conducted from 2018 to 2020 aimed to investigate the impacts of different tillage treatments (i.e., no tillage [CK], strip subsoiling tillage [ST], strip rotary tillage [RT], and strip rotary tillage after strip subsoiling [SRT]) on soil properties, water use efficiency (WUE), and forage productivity. Compared with CK, tillage practices significantly increased forage biomass and crude protein yield (CPY), particularly in the case of the SRT treatment, in which the increase was 20.8% and 25.3% higher, respectively (p < 0.05). Meanwhile, the net income in the SRT treatment exhibited the greatest value (US $1922.0 ha−1), showing a 17.0% increase compared with that in the CK treatment. The relationship of soil structure and crop water consumption became evident when tillage practices were applied in the degraded alfalfa pasture. The soil bulk density under the ST, RT, and SRT treatments decreased by 6.9%, 5.4%, and 8.6%, whereas the soil porosity increased by 8.6%, 6.7%, and 10.7% in the 0–60 cm soil layer, respectively (p < 0.05). Furthermore, the soil water content at a depth of 0–60 cm increased by 12.1% in the SRT treatment compared with the CK treatment at the harvesting stage, and the SRT treatment obtained the highest WUE of dry matter (16.9 kg ha−1 mm−1) and precipitation use efficiency of dry matter (15.8 kg ha−1 mm−1). In addition, total nitrogen in the ST, RT, and SRT treatments increased significantly by 21.4%, 11.1%, and 27.0%, respectively, and soil organic carbon in the ST, RT, and SRT treatments also increased significantly by 5.5%, 3.3%, and 10.4%, respectively, compared with those in the CK treatment (p < 0.05). Our study has demonstrated that tillage practices can optimize soil structure, improve water utilization, and increase soil fertilizer for enhancing forage productivity. The SRT practice could be a preferable approach for sustainable agricultural production of degraded alfalfa grassland in the semiarid region of China.
Impact of Digital Inclusive Finance and Environmental Regulation on Eco‐Efficiency of Farmland Utilization in China
Authors: Lu Hua , Luo Jiawei , Zhou Laiyou , Ye Jing 
Published: October 2024

ABSTRACTThe farmland pollution has threatened the lifeblood of people's livelihoods through the soil‐to‐crop system, and the resulting food safety risks are becoming more and more pronounced. Digital inclusive finance (DIF) can provide convenient financial services for the eco‐transformation of farmland utilization. This study analyzed the spatial evolution pattern of eco‐efficiency of farmland utilization (EEFU) and DIF, empirically tested the impact of DIF on EEFU, and discussed the impact of DIF on EEFU with changes in the level of environmental regulatory intensity based on panel data from 2011 to 2022 in China. The results found that the development of EEFU and DIF is increasing, and the polarization phenomenon is constantly easing, but the absolute differences between different provinces in China have an expanding trend. DIF can improve the EEFU, and this promotion effect is more pronounced in eastern and central China, non‐grain‐producing areas, and areas with low levels of financial development. DIF will not be able to improve EEFU until environmental regulation has reached a certain level. China should fully leverage the positive role of DIF and environmental regulations in promoting the EEFU, provide more differentiated financial products, financial tools, and financial models for the eco‐transformation of farmland utilization, and explore a path for eco‐transformation of farmland utilization that complements environmental regulations and development of market‐inclusive finance.
Dynamically Crosslinked Hydrogels Composed of Carboxymethyl Chitosan and Tannic Acid for Sustained Release of Encapsulated Protein
Authors: Yamada Tasuku , Mizuno Yosuke , Tian Li , Kitaguchi Tetsuya , Fujie Toshinori 
Published: October 2024

AbstractPolysaccharide‐based hydrogels are promising for biomedical applications such as drug delivery owing to their biocompatibility, biodegradability, and bioactivities. In particular, there is a need for hydrogels with injectability for minimally invasive therapies and controlled sustained release for sustained drug effect. Hydrogels made from carboxymethyl chitosan (CMC) and tannic acid (TA) (CMC‐TA) contain dynamic covalent bonds owing to autoxidation between CMC and TA, and interact with proteins via TA, elucidation of the detailed mechanism of dynamic covalent bonding in CMC‐TA hydrogels will facilitate stable loading and zero‐order release of proteins. Herein, the physical properties of oxidized CMC‐TA (Oxi‐CMC‐TA) prepared for the encapsulation and sustained release of proteins are explored. Following incubation at 37 °C for 24 h, CMC‐TA undergoes secondary crosslinking by autoxidation to produce Oxi‐CMC‐TA. Notably, CMC‐TA is viscoelastic and shear‐thinning, allowing for injection and 3D bioprinting. Indeed, CMC‐TA can be 3D‐printed with green fluorescent protein (GFP) encapsulated in its matrix. Oxi‐CMC‐TA also exhibits an affinity for protein owing to its gallol groups, enabling Oxi‐CMC‐TA to collect GFP in aqueous solutions against a concentration gradient. Moreover, Oxi‐CMC‐TA releases GFP over 15 days. Injectable, 3D‐printable, protein‐collecting, and zero‐order sustained‐releasing Oxi‐CMC‐TA has the potential to make a significant contribution to drug delivery.
Quantum Simulations of Radiation Damage in a Molecular Polyethylene Analog
Authors: Troup Nathaniel , Kroonblawd Matthew P. , Donadio Davide , Goldman Nir 
Published: October 2024

AbstractAn atomic‐level understanding of radiation‐induced damage in simple polymers like polyethylene is essential for determining how these chemical changes can alter the physical and mechanical properties of important technological materials such as plastics. Ensembles of quantum simulations of radiation damage in a polyethylene analog are performed using the Density Functional Tight Binding method to help bind its radiolysis and subsequent degradation as a function of radiation dose. Chemical degradation products are categorized with a graph theory approach, and occurrence rates of unsaturated carbon bond formation, crosslinking, cycle formation, chain scission reactions, and out‐gassing products are computed. Statistical correlations between product pairs show significant correlations between chain scission reactions, unsaturated carbon bond formation, and out‐gassing products, though these correlations decrease with increasing atom recoil energy. The results present relatively simple chemical descriptors as possible indications of network rearrangements in the middle range of excitation energies. Ultimately, the work provides a computational framework for determining the coupling between nonequilibrium chemistry in polymers and potential changes to macro‐scale properties that can aid in the interpretation of future radiation damage experiments on plastic materials.
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota
Authors: Zou Zebin , Xiao Nan , Chen Zhixian , Lin Xucong , Li Yaqi , Li Pan , Cheng Qian , Du Bing 
Published: October 2024

ScopeDepression as a global neurological disorder, and hippocampal neuronal apoptosis and disorders of the gut microbiota are closely related to it. This study aims to expose the ameliorative effect of enzyme peptides (AP) from brewer's yeast on depressive behavior caused by chronic restraint stress (CRS) in rats.Methods and resultsAfter 4 weeks of AP intervention, a significant alleviation of depressive behavior in the sucrose preference test (SPT), forced swim test (FST), and light‐dark test (LDT) is observed in depressed rats. AP ameliorates neuronal damage with increased the expression of the key CREB/BDNF/TrkB/Akt signaling pathway, which increases the levels of the monoamine neurotransmitters 5‐hydroxytryptamine (5‐HT) and norepinephrine (NE) in the hippocampus, buffering hyperactivity of the hypothalamo‐pituitary‐adrenal axis (HPA), and decreasing the serum cortisol (CORT) and adrenocorticotropic hormone (ACTH) levels in rats. In addition, AP modulates the disruption of the rat gut microbiota by chronic restraint stress (CRS), and the changes in the abundance of Lactobacillus animalis and Lactobacillus johnsonii are probably the key for AP performing antidepressant benefits. A strong correlation is found between gut microbiota and biochemical markers of depression.ConclusionAP, as a natural and safe active substance, has a positive effect in the treatment of depression.
Analytical Solutions for Composite Foundations Reinforced by Partially Penetrated Stone Columns and Vertical Drains
Authors: Li Chuanxun , Lu Xiangzong 
Published: October 2024

ABSTRACTWhen stone columns or vertical drains are applied to improve soils, it is common to face situations where the soft soil layer is too thick to be penetrated completely. Although consolidation theories for soils with partially penetrated vertical drains or stone columns are comprehensive, consolidation theories for impenetrable composite foundations containing both two types of drainage bodies have been few reported in the existing literature. Equations governing the consolidation of the reinforced zone and unreinforced zone are established, respectively. Analytical solutions for consolidation of such composite foundations are obtained under permeable top with impermeable bottom (PTIB) and permeable top with permeable bottom (PTPB), respectively. The correctness of proposed solutions is verified by comparing them with existing solutions and finite element analyses. Then, extensive calculations are performed to analyze the consolidation behaviors at different penetration rates, including the total average consolidation degree defined by strain or stress and the distribution of the average excess pore water pressure (EPWP) along the depth. The results show that the total average consolidation rate increases as the penetration rate increases; for some composite foundations with a low penetration rate, the consolidation of the unreinforced zone cannot be ignored. Finally, according to the geological parameters provided by an actual project, the obtained solution is used to calculate the settlement, and the results obtained by the proposed solution are in reasonable agreement with the measured data.
Suppression of dystroglycan function accompanies pancreatic acinar‐to‐ductal metaplasia and favours dysplasia development
Authors: Huang Ge , Ternes Luke , Lanciault Christian , MacPherson‐Hawthorne Kevin , Chang Young Hwan , Sears Rosalie C , Muschler John L 
Published: October 2024

AbstractThe basement membrane (BM) is among the predominant microenvironmental factors of normal epithelia and of precancerous epithelial lesions. Evidence suggests that the BM functions not only as a barrier to tumour invasion but also as an active tumour‐suppressing signalling substrate during premalignancy. However, the molecular foundations of such mechanisms have not been elucidated. Here we explore potential tumour‐suppressing functions of the BM during precancer evolution, focusing on the expression and function of the extracellular matrix receptor dystroglycan in the pancreas and pancreatic disease. We show that the dystroglycan protein is highly expressed in the acinar compartment of the normal pancreas but lower in the ductal compartment. Moreover, there is a strong suppression of dystroglycan protein expression with acinar‐to‐ductal metaplasia in chronic pancreatitis and in all stages of pancreatic precancer and cancer evolution, from acinar‐to‐ductal metaplasia to dysplasia to adenocarcinoma. The conditional knockout of dystroglycan in the murine pancreas produced little evidence of developmental or functional deficiency. However, conditional deletion of dystroglycan expression in the context of oncogenic Kras expression led to a clear acceleration of pancreatic disease evolution, including accelerated dysplasia development and decreased survival. These data establish dystroglycan as a suppressor of pancreatic dysplasia development and one that is muted in chronic pancreatitis and at the earliest stages of oncogene‐induced transformation. We conclude that dystroglycan is an important mediator of the tumour‐suppressing functions of the BM during precancer evolution and that reduced dystroglycan function increases cancer risk, highlighting the dynamics of cell–BM interactions as important determinants of early cancer progression. © 2024 The Pathological Society of Great Britain and Ireland.
Short‐ and Long‐Term Outcomes of Prenatally Identified Congenital Aqueductal Stenosis by Fetal MRI
Authors: Smith Noah J. , Nagaraj Usha D. , Kline‐Fath Beth M. , Bierbrauer Karin S. , Habli Mounira , Venkatesan Charu 
Published: October 2024

ABSTRACTObjectiveProviding accurate prenatal prognostication for expectant parents is challenging due to limited literature on factors impacting outcomes in children with congenital aqueductal stenosis (CAS). This study stratified CAS patients into isolated or complex categories (presence of additional intra‐ or extra‐cranial anomalies or genetic syndromes) and evaluated both short‐ and long‐term outcomes. Additionally, the role of ventricular rupture was assessed.MethodsThis was a single center retrospective‐cohort study of CAS patients who underwent fetal MRI over a 10‐year period.ResultsOf 140 patients with CAS, 107 (76%) were complex and 33 (24%) were isolated. There were no differences in the size of ventricular enlargement or incidence of ventricular rupture between the two groups. 14 pregnancies were terminated, 9 experienced fetal demise/stillbirth, and there were 21 post‐natal deaths. Outcomes at the time of hospital discharge were available for 86 patients and long‐term follow‐up data for 64. CSF diversion (via ventriculoperitoneal shunt) was performed in 95% of complex and 71% of isolated CAS patients. Acutely, no differences were noted in seizures (complex: 10%; isolated: 18%) or respiratory support but there was an increased risk for feeding support. Risks for non‐ambulatory status (complex: 32% vs. isolated: 0%), epilepsy (complex: 56% vs. isolated: 19%) and long‐term gastrostomy tube assisted feeding (complex: 25.5% vs. isolated: 0%) were significantly greater with complex CAS. The presence of rupture did not impact clinical outcome.ConclusionPoor clinical outcome was associated with complex CAS. Ventricular rupture alone did not portend a poor outcome. Prenatal counseling can tailor prognostication by CAS type.