bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term evaluation of the degradation behavior of three apatite‐forming calcium phosphate cements
Authors: An Jie , Liao Hongbing , Kucko Nathan W. , Herber Ralf‐Peter , Wolke Joop G. C. , van den Beucken Jeroen J. J. P. , Jansen John A. , Leeuwenburgh Sander C. G. 
Published: January 2016

AbstractCalcium phosphate cements (CPCs) are injectable bone substitutes with a long clinical history because of their biocompatibility and osteoconductivity. Nevertheless, their cohesion upon injection into perfused bone defects as well as their long‐term degradation behavior remain major clinical challenges. Therefore, the long‐term degradation behavior of two types of α‐tricalcium phosphate‐based, apatite‐forming CPCs was compared to a commercially available apatite‐forming cement, that is HydroSetTM. Carboxyl methylcellulose (CMC) was used as cohesion promotor to improve handling properties of the two experimental cements, whereas poly (d, l‐lactic‐co‐glycolic) acid (PLGA) microparticles were added to introduce macroporosity and stimulate CPC degradation. All three CPCs were injected into defects drilled into rabbit femoral condyles and explanted after 4, 12, or 26 weeks, after which the bone response was assessed both qualitatively and quantitatively. CPCs without PLGA microparticles degraded only at the periphery of the implants, while the residual CPC volume was close to 90%. On the contrary, bone ingrowth was observed not only at the periphery of the CPC, but also throughout the center of the implants after 26 weeks of implantation for the PLGA‐containing CPCs with a residual CPC volume of approximately 55%. In conclusion, it was shown that CPC containing CMC and PLGA was able to induce partial degradation of apatite‐forming CPCs and concomitant replacement by bone tissue. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1072–1081, 2016.
5‐Aminoimidazole‐4‐carboxamide 1‐β‐D‐ribofuranoside reduces intimal hyperplasia of tissue engineering blood vessel by inhibiting phenotype switch of vascular smooth muscle cell
Authors: Wu Yangxiao , Liu Ge , Chen Wen , Yang Mingcan , Zhu Chuhong 
Published: January 2016

AbstractIntimal hyperplasia (IH) is the cause of clinical failure in patients with vascular transplants and intravascular stents. The proliferation and phenotype switching of vascular smooth muscle cells (VSMCs) play important roles in IH. Inhibiting the proliferation of VSMCs and maintaining the differentiated phenotype of VSMCs is one way to reduce IH. In this article, 5‐aminoimidazole‐4‐carboxamide 1‐β‐D‐ribofuranoside (AICAR) was used in experiments after drug screening. We found that the metabolism, autophagy, and differentiation of VSMCs were enhanced which were important to the normal function of VSMCs, but the secretion of VSMCs was reduced after AICAR treatment. AICAR induces G1 phase arrest and inhibits the proliferation of VSMCs using the MTT and EdU assays and cell cycle analysis. Then, the rat carotid artery vessel transplantation model was used to evaluate the function of AICAR in vivo. AICAR‐modified tissue‐engineered blood vessels (TEBVs) had a higher patency rate and less IH than the control TEBVs. In conclusion, AICAR can improve the normal function of VSMCs by increasing the metabolism and autophagy of VSMCs but inhibit the proliferation, paracrine, and phenotypes switching of VSMCs, further contribute the reducing of IH in TEBVs. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 744–752, 2017.
Highly controlled coating of strontium‐doped hydroxyapatite on electrospun poly(ɛ‐caprolactone) fibers
Authors: Weng Lin , Teusink Matthew J. , Shuler Franklin D. , Parecki Vivi , Xie Jingwei 
Published: January 2016

AbstractElectrospun fibers show great potential as scaffolds for bone tissue engineering due to their architectural biomimicry to the extracellular matrix (ECM). Cation substitution of strontium for calcium in hydroxyapatite (HAp) positively influences the mechanism of bone remodeling including enhancing bone regeneration and reducing bone resorption. The objective of this study was to attach strontium‐doped HAp (SrHAp) to electrospun poly(ɛ‐caprolactone) (PCL) fibers for creation of novel composite scaffolds that can not only mimic the architecture and composition of ECM but also affect bone remodeling favorably. We demonstrated for the first time the highly controlled SrHAp coatings on electrospun PCL fibers. We showed the reproducible manufacturing of composite fiber scaffolds with controllable thickness, composition, and morphology of SrHAp coatings. We further showed that the released strontium and calcium cations from coatings could reach effective concentrations within 1 day and endure more than 28 days. Additionally, the Young's modulus of the SrHAp‐coated PCL fibers was up to around six times higher than that of raw fibers dependent on the coating thickness and composition. Together, this novel class of composite fiber scaffolds may hold great promise for bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 753–763, 2017.
Parenchyma‐preserving hepatectomy based on portal ramification and perfusion of the right anterior section: preserving the ventral or dorsal area
Authors: Kurimoto Ami , Yamanaka Junichi , Hai Seikan , Kondo Yuichi , Sueoka Hideaki , Ohashi Koichiro , Asano Yasukane , Hirano Tadamichi , Fujimoto Jiro 
Published: January 2016

AbstractBackgroundAnatomical hepatectomy aims to eliminate the spread of malignant tumor cells via portal vein systemically. An anatomical concept of the right anterior section (RAS) and preservation of the liver parenchyma within the RAS has been proposed.MethodsWe focused on the anatomical concept of the RAS based on portal perfusion and described surgical procedures to preserve the ventral or dorsal RAS using preoperative simulation.ResultsIn 370 patients undergoing a preoperative simulation, the ramification of the tertiary portal branches of the RAS could be divided into three types including the cranio‐caudal type; Couinaud's classification in 50% of patients, ventro‐dorsal type in 26% of patients, and multiple type in 24% of patients. Then in 32 patients of the ventro‐dorsal type, curative parenchyma‐sparing hepatectomy of the RAS was performed, preserving the ventral and dorsal RAS in 14 and 18 patients, respectively. There were no differences in the postoperative complications and long‐term survival compared with the results obtained after segment 5 or 8 resection (n = 33).ConclusionThree‐dimensional simulation revealed three types of portal vein ramification of the RAS. Parenchyma‐preserving hepatectomy based on the precise portal ramification may contribute to safe and curative hepatectomy in selected cases with liver neoplasm involving the RAS.
Effects of lidocaine on torn rotator cuff tendons
Authors: Honda Hirokazu , Gotoh Masafumi , Kanazawa Tomonoshin , Nakamura Hidehiro , Ohta Keisuke , Nakamura Kei‐ichiro , Shiba Naoto 
Published: January 2016

ABSTRACTWe determined lidocaine's action on torn rotator cuff tendons in vitro and in vivo. For in vitro experiments, cell proliferation and viability assays were performed using tenocytes derived from human torn rotator cuff tendons. For in vivo experiments, acute rotator cuff tears were made on the supraspinatus tendons in the rats’ bilateral shoulders; before closure, lidocaine was injected into the shoulder and saline into the contralateral shoulder (control). After sacrifice, the specimens underwent biomechanical testing or histological analysis at 24 h and at 2, 4, and 8 weeks after surgery. The extent of collagen organization and apoptosis were semi‐quantitatively evaluated using collagen picrosirius red staining. Apoptosis was examined using TUNEL staining and electron microscopy. Cell proliferation decreased dose‐dependently. After exposure to 0.1% lidocaine for 24 h, cell viability decreased. Two and 4 weeks after surgery, the ultimate load to failure decreased more in the lidocaine group than in the control group, with significantly reduced stiffness in the lidocaine group 2 weeks after surgery. Collagen organization significantly decreased in the lidocaine group by 4 weeks after surgery but returned to baseline at 8 weeks. TUNEL staining detected numerous apoptotic tenocytes at the torn tendon edge exposed to lidocaine 24 h after surgery; electron microscopy confirmed the condensed cell nuclei. These changes were not observed in controls. Lidocaine caused cytotoxicity to tenocytes under both conditions, decreased biomechanical properties, and induced apoptosis and delay of collagen organization in this model. Subacromial lidocaine injections in patients with rotator cuff tears should be performed carefully. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1620–1627, 2016.
Recurrence and survival analysis of resected soft tissue sarcomas of pelvic retroperitoneal structures
Authors: Doepker Matthew P. , Hanna Karim H. , Thompson Zachary J. , Binitie Odion T. , Letson Douglas G. , Gonzalez Ricardo J. 
Published: January 2016

BackgroundThe purpose is to determine the clinicopathologic factors related to survival and recurrence of primary resected pelvic soft tissue sarcomas (STS).MethodsDemographic/clinical variables were recorded.ResultsThirty‐five pts were identified. Median follow‐up was 24.2 months. There were 23 (65.7%) high/intermediate‐grade and 12 (34.3%) low‐grade tumors included in the final analysis. Eight patients (22.9%) received neoadjuvant therapy. Margins were grossly negative in 27 (77.1%, 17‐R0, 10‐R1) and grossly positive (R2) in 8 (22.9%). Adjuvant therapy was used in 13 patients (37.1%). The 2‐ and 3‐year RFS was 56.5% and 51.3%, with 14 patients recurring at a median time of 16 months (6‐local, 8‐distant). All distant recurrences were in high‐grade tumors. There were no differences in RFS for margins (R0 vs. R1), neoadjuvant/adjuvant therapy, size (≥10 vs. <10 cm) or gender. High/intermediate‐grade tumors had worse RFS (P < 0.008). The 2‐ and 3‐year OS was 80.9%. OS was improved for R0/R1 resection (P < 0.001). Resection to R0/R1 margin was a significant predictor of improved OS (P = 0.001).ConclusionsHigh/intermediate‐grade lesions were associated with worse OS and RFS. Resection to gross negative margins was the only independent predictor of OS. Adjuvant therapy may be reserved for high‐grade lesions due to increased metastatic potential. J. Surg. Oncol. 2016;113:103–107. © 2016 Wiley Periodicals, Inc.
A maximum‐likelihood method to estimate a single ADC value of lesions using diffusion MRI
Authors: Jha Abhinav K. , Rodríguez Jeffrey J. , Stopeck Alison T. 
Published: January 2016

PurposeDesign a statistically rigorous procedure to estimate a single apparent diffusion coefficient (ADC) of lesion from the mean lesion signal intensity in diffusion MRI.Theory and MethodsA rigorous maximum‐likelihood technique that incorporated the statistics of the mean lesion intensity and accounted for lesion heterogeneity was derived to estimate the ADC value. Performance evaluation included comparison with the conventionally used linear‐regression and a statistically rigorous state‐of‐the‐art ADC‐map technique using realistic and clinically relevant simulation studies conducted with assistance of patient data for homogeneous and heterogeneous lesion models.ResultsThe proposed technique outperformed the linear‐regression and ADC‐map approaches over a large spectrum of signal‐to‐noise ratio, ADC, lesion size, image‐misalignment parameters, including at no image misalignment, and different amounts of lesion heterogeneity. The method was also superior at different sets of b values and in studies from specific patient‐image‐derived data. The technique took less than a second to execute.ConclusionsA rigorous, computationally fast, easy‐to‐implement, and convenient‐to‐use maximum‐likelihood technique was proposed to estimate a single ADC value of the lesion. Results provide strong evidence in support of the method. Magn Reson Med 76:1919–1931, 2016. © 2016 International Society for Magnetic Resonance in Medicine
Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐13C]pyruvate and 13C‐urea
Authors: Lau Angus Z. , Miller Jack J. , Robson Matthew D. , Tyler Damian J. 
Published: January 2016

PurposeTo demonstrate the feasibility of imaging a bolus of co‐polarized [1‐13C]pyruvate and 13C‐urea to simultaneously assess both metabolism and perfusion in the rodent heart.MethodsCopolarized [1‐13C]pyruvate and 13C‐urea was imaged using a multi‐echo, flow‐sensitized spiral pulse sequence. Healthy rats were scanned in a two‐factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress‐induced hyperemia).ResultsAlterations in metabolism were detected by changes in pyruvate metabolism into 13C‐bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals.ConclusionThe new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized 13C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151–158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine
Solar Electricity
Authors: Turan Raşit 
Published: January 2016

AbstractThis issue of physica status solidi (c) compiles the Proceedings of the 3rd Turkish Solar Electricity Conference and Exhibition (SolarTR‐3) that was held in Ankara, the capital city of Turkey, between April 27 and 29, 2015. Invited speakers, innovative companies and decision makers (politicians, government officials) experts in different types and various aspects of photovoltaics (PV) technology participated in this event. As the organization committee we were able to create a platform for interaction between private companies, university researchers and government officials for further R&D and production of PV in Turkey during this event. This year, we have organized the 3rd SolarTR after the two successful previous events, Solar‐TR1 in 2009 and Solar‐TR2 2012, more special and international by bringing researchers and private sector community from Turkey, Europe, USA and Middle Eastern Countries together. Proof of the vitality of the Solar‐TR series was given by the participation of 420 people with diverse backgrounds in photovoltaic technology; more than two hundreds out of them were PhD students or young scientists. The participants have presented 15 invited talks, 40 oral contributions and more than 105 visual presentations. The conference included also 2 plenary and 9 parallel sessions, and 2 tutorial sessions aimed at illustrating the basic photovoltaic energy technology and energy conversion to a broader community.All the published full papers in this issue were reviewed by a number of expert scientists in the field of photovoltaics to assure the high quality and diversity of this special issue.We thank both International and National Scientific Committees for their valuable contributions and wise suggestions. We also warmly thank the local Organizing Committee that had helped us tremendously. Finally, we would like to thank all sponsors of the SolarTR‐3 conference and exhibition.On behalf of the Organization CommitteeProf. Dr. Raşit TuranChair of SolarTR‐3 conference
Energy‐efficient link resource allocation in the multibeam satellite downlink under QoS constraints
Authors: Andreotti Riccardo , Giannetti Filippo , Luise Marco 
Published: January 2016

SummaryThis work deals with the issue of boosting the capacity of digital subscriber line networks in the presence of geographical gaps. To this aim, an effective approach consists in exploiting the downlink of multibeam satellites for the delivering of packed‐based traffic, employing modulation and coding schemes denoted by very high spectral efficiency, such as in Digital Video Broadcasting‐Satellite, version 2 and eXtension standard, although time‐varying channel and interference may severely affect the quality of the communication. To cope with these issues, this paper proposes a novel link resource adaptation based on the following features. First, to efficiently manage packet‐based transmissions, an adaptive coding and modulation scheme is derived aimed at maximizing the ‘goodput’, that is, the offered layer‐3 data rate. Then, in order to mitigate the co‐channel interference arising from beams exploiting the same band, an adaptive power control is also proposed. The goal of the latter is to maximize the energy efficiency of the satellite downlink guaranteeing a given quality‐of‐service, that is, a minimum‐goodput, over each link. This problem is modeled as a non‐cooperative game, and the conditions of feasibility, existence, and uniqueness of the solution are analytically derived. Finally, simulation results are provided comparing the proposed strategy with the conventional rate satisfaction power control approach. Copyright © 2016 John Wiley & Sons, Ltd.
A Study of the Factors and Conditions Associated with Graduate Enrollment Management Practitioners’ Participation in Professional Development
Authors: Balayan Ariana 
Published: January 2016

This investigation was designed to determine the factors and conditions associated with graduate enrollment management practitioners’ participation in professional development (PD) activities. The sample consisted of members of a professional association, the National Association of Graduate Admissions Professionals (NAGAP), focused solely on supporting graduate enrollment managers and related staff, whose patterns of involvement in various PD events for the previous five years were classified as low or inconsistent. In an effort to identify member preferences, as well as characteristics associated with PD activities, the investigator sought to provide information useful to developing future PD programs for NAGAP.An electronic quantitative instrument, the Professional Development in Graduate Enrollment Management (PDGEM) survey, consisted of closed‐ended questions related to PD grouped under the following headings: Demographic Information, Support for and Knowledge of Professional Development Activities, Attitudes and Beliefs about Professional Development: Individual and Institutional, Components of Professional Development in Graduate Enrollment Management, Professional Development Plans, Participation and Involvement in NAGAP Professional Development Activities, Other Organizations’ Professional Development, and Professional Development Overall. It was disseminated to 1,461 members of NAGAP, with a return rate of 163 (11%). Descriptive and linear regression analyses were conducted in order to discern (1) the frequency of participation in PD and (2) the demographic and other variables predictive of participation in PD.The study's findings revealed that about one‐quarter of the respondents participated regularly in NAGAP‐sponsored PD and that the involvement levels of the remainder of the membership were inconsistent. Additionally, on‐site activities were favored over online, content relevance greatly influenced whether practitioners participated, and member interest in conducting academic research was low. Cost was also a primary factor in determining participation in professional development.
Structural and Physicochemical Properties of a Polymerizable Surfactant Synthesized from N‐Methylol Acrylamide
Authors: Tamer Yasemin , berber Yamak Hale , Yıldırım Hüseyin 
Published: January 2016

AbstractA new polymerizable nonionic surfactant with reactive vinyl groups has been synthesized from N‐methylol acrylamide using a two‐step procedure. The structure of the surfactant molecule was characterized by Fourier transform infrared, 1H nuclear magnetic resonance and mass spectroscopy. The surface active properties alongside its self‐assembly properties were investigated by surface tension, electrical conductivity, and fluorescence spectroscopy measurements. As compared with other nonionic surfactants, this study showed that this polymerizable surfactant possesses slightly a higher critical micelle concentration (CMC) value and the surface tension value at CMC. The obtained CMC values were compatible among measurements, ca. 0.02–0.038 M. The evidence of micelle formation also provided by the zeta potential measurements and the obtained zeta potential values showed that the polymerizable surfactant solutions had limited stability. The hydrolysis stability and solubility of the polymerizable surfactant were also investigated. The solubility results have shown that it was soluble in polar solvents while insoluble in nonpolar solvents both at room temperature and 40 °C. The acidic and basic hydrolysis of the surfactant increased as the temperature increased and the hydrolysis stability was 180 min (basic medium) and 55 min (acidic medium) at 80 °C.
Does novel oral anticoagulant improve anticoagulation for non‐valvular atrial fibrillation associated stroke: An inpatient registration study in Shanghai
Authors: Liu Feng‐Di , Zhao Rong , Wang Xue‐Mei , Wang Shuo , Shen Xiao‐Lei , Tao Xiao‐Xiao , Zheng Bo , Peng Jia‐Li , Zhang Hui , Mo Ran , Tong Yan , Li Wen‐Ting , Feng Xiao‐Yan , Li Ge‐Fei , Shu Liang , Liu Jian‐Ren 
Published: January 2016

AbstractsObjectiveTo summarize the use rate, safety, efficacy of antithrombotics in stroke/transient ischemic attack (TIA) prevention, and reasons for not using dabigatran etexilate (DE) in Shanghai, China.MethodsNon‐valvular atrial fibrillation (NVAF)‐associated stroke patients were prospectively registered as an electronic database. Use rate of antithrombotics and reasons for not using DE were extracted during follow‐up. Patients' baseline characteristics, recurrent ischemic stroke/TIA events and bleeding complications were analyzed.PatientsFrom April 2012 to August 2014, 110 inpatients with NVAF‐associated stroke were studied in our hospital. NVAF was diagnosed by 12‐lead electrocardiogram, 24 h Holter and echocardiography.ResultsBefore introduction of DE (April 2013), use rates of warfarin and antiplatelets were 28.9% (11/38) and 60.5% (23/38) respectively; after that, use rates of warfarin, DE, and antiplatelets were 20.8% (15/72), 12.5% (9/72), and 43.1% (31/72). The DE did not improve use of anticoagulants (P = 0.639). There were 19 (17.3%) recurrent ischemic stroke events up to October 2015; two (9.5%) in the non‐user group, 10 (18.5%) in the antiplatelet group, and seven (20.0%) in the anticoagulants group (P = 0.570). Furthermore, recurrence rates were similar between the DE group (20.0%) and the Warfarin group (20.0%, P = 1.000). The most common reason for not using DE was financial concerns (61.0%), followed by inconvenience to purchase (14.0%) and hemorrhage concerns (11.0%). Two patients using warfarin found fecal occult blood so they stopped warfarin and began to use antiplatelet drugs. No bleeding event occurred in the other groups. Only one patient had side effects (dyspepsia and gastroesophageal reflux) from DE.ConclusionThe use rate of either DE or warfarin in Shanghai was low; DE had not improved anticoagulation therapy for NVAF patients in Shanghai mainly because DE had not been covered by health insurance.