bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Human SDHA-Knockout Cell Line Model for the Functional Analysis of Clinically Relevant SDHA Variants
Authors: Kent Jason D. , Klug Lillian R. , Heinrich Michael C. 
Published: September 2024

Abstract

Purpose:
SDHA mutations are the most common cause of succinate dehydrogenase (SDH)–deficient GIST. Enhanced cancer surveillance of individuals carrying a known pathogenic germline SDHA mutation has the potential to detect early-stage tumors, allowing for improved patient outcomes. However, more than 95% of the &gt;1,000 SDHA missense variants listed in ClinVar are variants of uncertain significance. Our ability to interpret the significance of SDHA variants must improve before genetic sequencing can be utilized to its full potential.

Experimental Design:
SDHA variants were introduced into a clonal SDHA-knockout cell line via Bxb1-mediated recombination. SDH activity and SDHA abundance were determined for each variant, and logistic regression analysis was used to derive functional evidence for clinical variant interpretation.

Results:
Our analysis revealed that cancer-associated SDHA missense variants can be clearly distinguished from noncancer variants according to the extent of SDH dysfunction caused. As such, SDH activity data can be used to predict cancer pathogenicity with strong performance metrics, exceeding those of computational prediction tools. From these data, we obtained functional evidence for clinical variant interpretation from 21 of 22 assayed variants of uncertain significance, with 19 in favor of cancer pathogenicity and two against pathogenicity. Lastly, simulating the addition of our functional evidence with limited preexisting evidence allowed for 18 of 22 variants to be reclassified.

Conclusions:
We describe a novel pipeline for investigating the functional consequences of SDHA missense variants. In total, we characterized 72 variants, developed criteria for obtaining functional evidence, and demonstrated the potential of this evidence for clinical variant interpretation.
Update on Surveillance for Wilms Tumor and Hepatoblastoma in Beckwith–Wiedemann Syndrome and Other Predisposition Syndromes
Authors: Kalish Jennifer M. , Becktell Kerri D. , Bougeard Gaëlle , Brodeur Garrett M. , Diller Lisa R. , Doria Andrea S. , Hansford Jordan R. , Klein Steven D. , Kohlmann Wendy K. , Kratz Christian P. , MacFarland Suzanne P. , Pajtler Kristian W. , Rednam Surya P. , Schienda Jaclyn , States Lisa J. , Villani Anita , Weksberg Rosanna , Zelley Kristin , Tomlinson Gail E. , Brzezinski Jack J. 
Published: September 2024

Abstract
Wilms tumors are commonly associated with predisposition syndromes, many but not all of which include overgrowth. Several of these syndromes also include a risk of other embryonal malignancies—particularly hepatoblastoma. Guidelines for surveillance in this population were published in 2017, and recently, members of the American Association for Cancer Research Pediatric Cancer Working Group met to update those guidelines with a review of more recently published evidence and risk estimates. This perspective serves to update pediatric oncologists, geneticists, radiologists, counselors, and other health care professionals on revised diagnostic criteria; review previously published surveillance guidelines; and harmonize updated surveillance recommendations in the North American and Australian contexts for patients with overgrowth syndromes and other syndromes associated with Wilms tumor predisposition.
Retaliatory Tariffs of China during the Trade War: A Firm-level Overview
Authors: Liu Nan , Tian Wei , Zheng Chunru 
Published: September 2024

Abstract
In this paper, we offer a comprehensive survey of the latest research regarding the pass-through of tariffs during the trade war between China and the United States, with an emphasis on the investigations conducted from the Chinese perspective. While one might anticipate symmetric effects on both the United States and China, these nations exhibit substantial disparities in terms of trade structure and policy. We underscore two salient concerns that have been largely neglected in extant literature: (1) the exemption of processing imports from retaliatory tariffs in China, which may engender biased estimations of pass-through at the product level, and (2) the heterogeneous distribution of retaliatory tariffs across product classifications, firm ownership structures, and geographical regions, necessitating more granular estimations at the firm level. Furthermore, we provide a detailed description of firm import tariffs, emphasizing the crucial role of tailored policies in mitigating the repercussions of the trade conflict.
Trauma Healing through Psalms 136–139: a Trauma-Informed Canon-Critical Framework
Authors: Garland John , Poe Hays Rebecca W. 
Published: September 2024

Abstract
This article draws together insights from trauma theory and the conversation in Psalms scholarship known as “Psalmenexegese und Psalterexegese” or as the question of “shape and shaping” to propose a reading of Pss 136–139 as a pathway to trauma healing. This sequence of psalms moves participants toward healing by preparing them for the work of trauma healing through a mantra-like focus (Ps 136), unleashing the full range of human stress-responses to trauma (Ps 137), directly answering each of these stress-responses (Ps 138), and then—in a dramatic resolution—characterizing God as intimately concerned with human biology and life while continuing to acknowledge ongoing experiences of pain and injustice (Ps 139). The article illustrates the proposed framework for trauma healing with examples from pastoral work with asylum-seekers.
Reader-Created Content: the ‘Reader and Reporter’ (Dokja wa gija) Features in the Donga ilbo, January–November 1925
Authors: Shin Michael D. 
Published: September 2024

Abstract
This article examines the ‘Reader and Reporter’ (Dokja wa gija) section of the newspaper Donga ilbo, which first appeared on 1 January 1925. Readers could both submit articles on topics selected by reporters and suggest topics for reporters to write about. Over the course of its run, a total of thirty-one features were published, only five of which were written by readers. The ‘Reader and Reporter’ section provides a direct view of the interactions between reporters and readers that shaped the format and content of the newspaper. After an overview of the society desk and the society page of the newspaper, this article focuses on the most common type of feature requested by readers: personal profiles of well-known figures. They can be seen as efforts to counter two trends of the time: the forgetting of the 1919 March First Movement and the depoliticization of women.
Legal Feminism: Wang Ruqi and the 1950 Marriage Law
Authors: Li Shangyang , He Qiliang 
Published: September 2024

Abstract
This article analyses Wang Ruqi’s 王汝琪 (1912–1990) contribution to the drafting of the 1950 Marriage Law, the first codified law promulgated by the People’s Republic of China (PRC). It argues that Wang–who had been a legal specialist and a female political activist dating back to the 1930s and 1940s–was the actual author of the law’s first draft. In rehabilitating Wang’s long-forgotten contribution to the making of the Marriage Law, this study highlights that, first of all, lawmaking in the early years of the PRC was characterized by legal “professionalism,” rather than the “vernacularism” that scholars in recent years have tended to ascribe to this period. Second, Wang was an exemplary figure of a new breed of “state feminists” in the PRC, which we term “state-legal feminists.” State-legal feminists, like state feminists in general, were brought into the PRC state apparatus and took advantage of their role in the state to advance sociopolitical agendas. However, they differed from their fellow state feminists because they firmly believed that the state’s will and intent could be best articulated and exercised through codified laws and legal institutions. The making of the Marriage Law thus exemplifies the state-legal feminist approach insofar as it resorted to a codified law to push for the political agendas of women’s emancipation and restructuring families in China. While recent scholarship highlights the politicization of the law in the 1953 campaign to promote the Marriage Law, this study inverts this by addressing the legalization of political and social movements.
From Rent and Interest Reduction to the “May Fourth” Directive: Rent Reduction and the Settling of Accounts during the Transitional Period – A Study Centered on Guo County in the Jin-Sui Border Region
Authors: Yue Qianhou , Su Ming 
Published: September 2024

Abstract
Rent reduction and the settling of accounts was an essential pathway for the CCP’s land policy to transition from the policy of rent and interest reduction to “land to the tiller.” It primarily involved peasants obtaining a certain amount of productive and living resources from those targeted in the settling of accounts. As the fruits of the settlement were distributed, subtle changes in land rights occurred among various social strata in certain areas and villages of Guo County, showing a trend of “stability in the middle, equality at both ends” 中间不动，两头平. To be sure, during the process of rent reduction and the settling of accounts, the CCP had to face numerous challenges due to the low level of peasants’ ideological consciousness, interference from hostile forces, and poor attitudes and work styles of cadres. However, with effective policy measures, the movement in Guo County achieved significant success. Peasants experienced a dual economic and political liberation to a certain extent, greatly stimulating their enthusiasm for production and for enlistment in the army. Meanwhile, the ranks of the CCP were tempered through this struggle, accumulating valuable experience for the implementation of subsequent land reform policies.
Glycerol conversion and power generation in microbial fuel cells: insect exuviae biochar as electrodes and insect frass as biostimulants
Authors: Lin C.-W. , Liu S.-H. , Chang A.-S. , Cheng Y.-S. 
Published: September 2024

Abstract
Insects are a suitable raw material for refinement into biodiesel owing to their high fat content, but the refining process produces large amounts of insect waste and glycerol as a byproduct. Biochar electrodes were produced from insect waste for application in microbial fuel cells (MFCs), and experiments were performed to evaluate the electrochemical performance and glycerol conversion efficiency. The biochar was characterized by rich functional groups (O–H, O=C=O, C=C, C=O) and high microporosity, which favored the colonization of microbes. Among the electrode configurations considered, the optimal configuration was a biochar anode and carbon cloth cathode (B-MFC), showing the highest glycerol conversion efficiency (>95%). The B-MFC also exhibited the highest power density (122.3 mA/m3), 1.46-2.34 times that of the other MFCs tested. Adding Nitrogen-rich insect frass to the anode tank further stimulated microbial growth and increased power production, with the highest voltage output of 443.2 mV at 10 mg/L nitrogen concentration, 1.18 times higher than without addition. This study is the first to utilize insect exuviae as biochar electrodes in an MFC to solve the problems of excessive insect waste from biodiesel refinement and converting glycerol into a renewable energy source.
المشاركة في الانتخابات العامة بين التنظير الفقهي والدراسات الإبستقراطية: مقاربة مقاصدية أخلاقية
Authors: أمزيان محمد 
Published: September 2024

الخلاصة
‫تعاملت الأدبيات السياسية الإسلامية المعاصرة مع موضوع الانتخابات من منظور تأصيلي يسوغ مواقف إيجابية مسبقة، وكان من نتائج هذه المنهجية أنها أغفلت التداعيات السلبية التي تلازم العملية الانتخابية. ومن هذا المنطلق تتبنى هذه الورقة مقاربة نقدية من شأنها أن تحفز العقل الفقهي المعاصر على التعامل العقلاني مع هذا الموضوع بهدف الإسهام في تخليق المشاركة السياسية بدلًا من تكريس أخطائها. والتصور الذي تقترحه هذه الدراسة هو تقييد الانتخابات العامة بضوابط أخلاقية ومعرفية من شأنها أن تقلل من التداعيات السلبية التي تلازم ظاهرة التحزب السياسي. وهذا التصور يحظى بتوافق كل من الفقهاء المسلمين ورواد النظرية الإبستقراطية، وكلاهما يقدم أفكارا متقدمة تشكل تحديًا لتقاليد الممارسة الديموقراطية على مستوى المشاركة السياسية.‬
Dexamethasone dose intensity does not impact outcomes in newly diagnosed multiple myeloma: a secondary SWOG analysis
Authors: Banerjee Rahul , Sexton Rachael , Cowan Andrew J. , Rosenberg Aaron S. , Ailawadhi Sikander , Rajkumar S. Vincent , Kumar Shaji , Dispenzieri Angela , Lonial Sagar , Durie Brian G. M. , Richardson Paul G. , Usmani Saad Z. , Hoering Antje , Orlowski Robert Z. 
Published: September 2024

Abstract
Dexamethasone is a key component of induction for newly diagnosed multiple myeloma (NDMM), despite common toxicities, including hyperglycemia and insomnia. In the randomized ECOG E4A03 trial, dexamethasone 40 mg once weekly was associated with lower mortality than higher doses. However, the performance of dexamethasone dose reductions below this threshold with regard to progression-free survival (PFS) and overall survival (OS) in NDMM has not been fully characterized. We conducted a secondary pooled analysis of the SWOG 0777 and SWOG 1211 studies of NDMM, which used lenalidomide and dexamethasone (Rd) alone, with or without bortezomib, and with or without elotuzumab. The planned dexamethasone intensity was 40 to 60 mg weekly in all arms. Patients were categorized into FD-DEX (full-dose dexamethasone maintained throughout induction) or LD-DEX (lowered-dose dexamethasone or discontinuation; only permitted for grade 3+ toxicities per both study protocols). Of the 541 evaluated patients, the LD-DEX group comprised 373 patients (69%). There were no differences in PFS or OS between the FD-DEX and LD-DEX groups, which were balanced in terms of age, stage, and performance status. Predictors of PFS and OS in the multivariate models were treatment arm, age ≥70 years, and thrombocytopenia. FD-DEX did not significantly improve either outcome. Our study suggests that dexamethasone dose reductions are common in multiple myeloma, even within clinical trials. Given the many toxicities and unclear benefits of dexamethasone in the era of modern treatment regimens, dexamethasone dose reduction during NDMM induction warrants further prospective studies. These trials were registered at www.clinicaltrials.gov as #NCT00644228 and NCT01668719.
A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies
Authors: Wirbel Jakob , Essex Morgan , Forslund Sofia Kirke , Zeller Georg 
Published: September 2024

Abstract

Background
In microbiome disease association studies, it is a fundamental task to test which microbes differ in their abundance between groups. Yet, consensus on suitable or optimal statistical methods for differential abundance testing is lacking, and it remains unexplored how these cope with confounding. Previous differential abundance benchmarks relying on simulated datasets did not quantitatively evaluate the similarity to real data, which undermines their recommendations.

Results
Our simulation framework implants calibrated signals into real taxonomic profiles, including signals mimicking confounders. Using several whole meta-genome and 16S rRNA gene amplicon datasets, we validate that our simulated data resembles real data from disease association studies much more than in previous benchmarks. With extensively parametrized simulations, we benchmark the performance of nineteen differential abundance methods and further evaluate the best ones on confounded simulations. Only classic statistical methods (linear models, the Wilcoxon test, t-test), limma, and fastANCOM properly control false discoveries at relatively high sensitivity. When additionally considering confounders, these issues are exacerbated, but we find that adjusted differential abundance testing can effectively mitigate them. In a large cardiometabolic disease dataset, we showcase that failure to account for covariates such as medication causes spurious association in real-world applications.

Conclusions
Tight error control is critical for microbiome association studies. The unsatisfactory performance of many differential abundance methods and the persistent danger of unchecked confounding suggest these contribute to a lack of reproducibility among such studies. We have open-sourced our simulation and benchmarking software to foster a much-needed consolidation of statistical methodology for microbiome research.
Mediation, emotion, and agency from an activity theoretical perspective as potential analytical tools for inquiry into language teacher cognition: clarifications and implications
Authors: Truong Khoa Dang 
Published: September 2024

AbstractDrawing inspiration from the sociocultural turn in language teacher cognition research, this conceptual article argues for the utilisation of cultural-historical activity theory (CHAT) as a theoretical framework for researching and understanding teacher cognition as a social phenomenon. In this article, three CHAT-related concepts, namely mediation, including contradictions; emotion; and agency are expounded, drawn together, and proven as pertinent and useful analytical tools for the study of the complexity of teacher cognition. Its central thesis posits that CHAT accommodates teachers’ sociocultural activity systems whose mechanism is characterised by mediation that stimulates their emotional responses and agency for taking actions—a process through which teacher cognition unfolds in dynamic, developmental manners. By mapping these concepts, the article contributes to the extant scholarship by highlighting language teacher cognition as a mediated, emotional, and agentive process of transformation and providing critical epistemological implications for prospective empirical attempts in this line of research.
Relationships between human serum albumin levels and septic shock, in-hospital, and out-of-hospital mortality in elderly patients with pneumonia in different BMI ranges
Authors: Huang Sha , Chen Lanlan , Yang Ning , Zhang Jiao , Wang Yan , Chen Xiaoyan 
Published: September 2024

Abstract
Objective
This retrospective cohort identified the association of human serum albumin (HSA) with adverse outcomes (septic shock, in-hospital and out-of-hospital mortality) in elderly hospitalized patients who have community-acquired pneumonia (CAP) and specific body mass index (BMI).

Materials and methods
This research included hospitalized CAP individuals (≥ 60 years) and was conducted at a teaching hospital in western China. All the patients were categorized into three populations based on two BMI cutoff values (18.5 kg/m2 and 24 kg/m2). The data was acquired from medical records, local government mortality databases, and telephone interviews. Binomial logistic regression analysis was used to explore the associations between low HSA and septic shock and in-hospital mortality, and Cox regression analysis was used to explore the association between low HSA and out-of-hospital mortality.

Results
A total of 627 patients were included in the analysis of in-hospital death and septic shock, and 431 patients were included in the analysis of out-of-hospital death. The study showed that 120 elderly patients with CAP (19.14%) died in the hospital, while 141 patients (32.71%) died out of the hospital, and 93 patients (14.83%) developed septic shock. No differences in in-hospital and out-of-hospital mortality were observed for BMI values < 18.5 kg/m2 or BMI ≥ 24 kg/m2, regardless of whether HSA was ≥ 40 g/l or < 40 g/l. When 18.5 kg/m2 ≤ BMI < 24 kg/m2, patients with HSA < 40 g/l had both higher in-hospital and out-of-hospital mortality compared with those with HSA ≥ 40 g/l (in-hospital death: 26.13% vs. 11.46%, p < 0.001; out-of-hospital death: 46.15% vs. 19.17%, p < 0.001). No significant differences were observed in the incidence of septic shock between patients with HSA < 40 g/l and those with HSA ≥ 40 g/l either in the overall population or when the BMI values were divided according to the cutoff values of 18.5 kg/m2 and 24 kg/m2. After further logistic regression analysis and adjustment for potential confounders, the results showed that when 18.5 kg/m2 ≤ BMI < 24 kg/m2, elderly CAP patients with HSA < 40 g/l had a higher risk of in-hospital and out-of-hospital mortality compared with those with HSA ≥ 40 g/l (in-hospital death: HR = 1.964, 95%CI = 1.08–3.573; out-of-hospital death: HR = 2.841, 95%CI = 1.745–4.627).

Conclusions
HSA levels can predict the risk of in-hospital and out-of-hospital mortality in elderly patients with CAP and normal BMI values. However, HSA cannot predict the risk of septic shock in elderly patients hospitalized with CAP, irrespective of their BMI classification.
Long-term study of the combined effects of ocean acidification and warming on the mottled brittle star, Ophionereis fasciata
Authors: Márquez-Borrás Francisco , Sewell Mary A. 
Published: September 2024

ABSTRACT
The global ocean is rapidly changing, posing a substantial threat to the viability of marine populations due to the co-occurrence of multiple drivers, such as ocean warming (OW) and ocean acidification (OA). To persist, marine species must undergo some combination of acclimation and adaptation in response to these changes. Understanding such responses is essential to measure and project the magnitude and direction of current and future vulnerabilities in marine ecosystems. Echinoderms have been recognised as a model in studies of OW–OA effects on marine biota. However, despite their global diversity, vulnerability and ecological importance in most marine habitats, brittle stars (ophiuroids) are poorly studied. A long-term mesocosm experiment was conducted on adult mottled brittle star (Ophionereis fasciata) as a case study to investigate the physiological response and trade-offs of marine organisms to ocean acidification, ocean warming and the combined effect of these two drivers. Long-term exposure of O. fasciata to high temperature and low pH affected survival, respiration and regeneration rates, growth rate, calcification/dissolution and righting response. Higher temperatures increased stress and respiration, and decreased regeneration and growth rates as well as survival. Conversely, changes in pH had more subtle or no effect, affecting only respiration and calcification. Our results indicate that exposure to a combination of high temperature and low pH produces complex responses for respiration, righting response and calcification. We address the knowledge gap of the impact of a changing ocean on ophiuroids in the context of echinoderm studies, proposing this class as an ideal alternative echinoderm for future research.