bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration
Authors: Parrell Benjamin , Agnew Zarinah , Nagarajan Srikantan , Houde John , Ivry Richard B. 
Published: August 2017

The cerebellum has been hypothesized to form a crucial part of the speech motor control network. Evidence for this comes from patients with cerebellar damage, who exhibit a variety of speech deficits, as well as imaging studies showing cerebellar activation during speech production in healthy individuals. To date, the precise role of the cerebellum in speech motor control remains unclear, as it has been implicated in both anticipatory (feedforward) and reactive (feedback) control. Here, we assess both anticipatory and reactive aspects of speech motor control, comparing the performance of patients with cerebellar degeneration and matched controls. Experiment 1 tested feedforward control by examining speech adaptation across trials in response to a consistent perturbation of auditory feedback. Experiment 2 tested feedback control, examining online corrections in response to inconsistent perturbations of auditory feedback. Both male and female patients and controls were tested. The patients were impaired in adapting their feedforward control system relative to controls, exhibiting an attenuated anticipatory response to the perturbation. In contrast, the patients produced even larger compensatory responses than controls, suggesting an increased reliance on sensory feedback to guide speech articulation in this population. Together, these results suggest that the cerebellum is crucial for maintaining accurate feedforward control of speech, but relatively uninvolved in feedback control.SIGNIFICANCE STATEMENTSpeech motor control is a complex activity that is thought to rely on both predictive, feedforward control as well as reactive, feedback control. While the cerebellum has been shown to be part of the speech motor control network, its functional contribution to feedback and feedforward control remains controversial. Here, we use real-time auditory perturbations of speech to show that patients with cerebellar degeneration are impaired in adapting feedforward control of speech but retain the ability to make online feedback corrections; indeed, the patients show an increased sensitivity to feedback. These results indicate that the cerebellum forms a crucial part of the feedforward control system for speech but is not essential for online, feedback control.
Medicaid Managed Care Structures and Care Coordination
Authors: Gilchrist-Scott Douglas H. , Feinstein James A. , Agrawal Rishi 
Published: August 2017

BACKGROUND:
Child enrollment in Medicaid managed care (MMC) has expanded dramatically, primarily through state mandates. Care coordination is a key metric in MMC evaluation because it drives much of the proposed cost savings and may be associated with improved health outcomes and utilization. We evaluated the relationships between enrollment in 2 MMC structures, primary care case management (PCCM) and health maintenance organization (HMO) and access to and receipt of care coordination by children.

METHODS:
Using data from the 2011/2012 National Survey of Children’s Health and the Medicaid Statistical Information System state data mart, we conducted a retrospective, cross-sectional analysis of the relationships between fee-for-service, PCCM or HMO enrollment, and access to and receipt of care coordination. State-level univariate analyses and individual and state multilevel multivariable analyses evaluated correlations between MMC enrollment and care coordination, controlling for demographic characteristics and state financing levels.

RESULTS:
In univariate and multilevel multivariable analyses, the PCCM penetration rate was significantly associated with increased access to care coordination (adjusted odds ratio: 1.23, P = .034) and receipt of care coordination (adjusted odds ratio: 1.37, P = .02). The HMO penetration rate was significantly associated with lower access to care coordination (adjusted odds ratio: 0.85, P = .05) and receipt of care coordination (adjusted odds ratio: 0.71, P &lt; .001). Fee-for-service served as the referent.

CONCLUSIONS:
State utilization of MMC varied widely. These data suggest that care coordination may be more effective in PCCM than HMO structures. States should consider care coordination outcomes when structuring their Medicaid programs.
A Multidimenzionális Észlelt Társas Támogatás Kérdőív magyar nyelvű validálása
Authors: Papp-Zipernovszky Orsolya , Kékesi Márk Zoltán , Jámbori Szilvia 
Published: August 2017

Elméleti háttér
A társas beágyazottság az optimális funkcionálás, a jóllét egyik komponense. Emellett hazai és nemzetközi eredmények szerint is a lelki és testi egészség megőrzésének kulcstényezője – elsősorban stresszhelyzetekben. A Multidimenzionális Észlelt Társas Támogatás Kérdőívet (Multidimensional Scale of Perceived Social Support; MSPSS) 1988-ban fejlesztették ki Zimet és munkatársai, és azóta több európai és ázsiai nyelvre is lefordították. A kérdőív pszichometriai jellemzői a legtöbb esetben kiválóak. Cél: Mivel magyar nyelven jelenleg egyetlen validált, a Caldwell-féle, társas támogatást mérő kérdőív érhető el, amelynek a kiértékelése nehezen számszerűsíthető, tanulmányunk célja, hogy bemutassuk a MSPSS kérdőív magyar nyelvű validálását felnőtt mintán (n = 1073; 72,9% nő).

Módszerek
A feltáró faktoranalízis mellett megerősítő eljárást is alkalmaztunk. A konvergens és divergens validitás vizsgálatára a következő mérőeszközöket használtuk fel: Társas Támogatás Erőssége Kérdőív, Caldwell-féle Társas Támogatás Kérdőív, Általános Énhatékonyság Skála, Big Five Kérdőív Extraverzió és Barátságosság skálái és a Családi Szocializáció Kérdőív.

Eredmények
A feltáró és megerősítő faktorelemzés eredményei alapján a végső kérdőívben 10 tétel maradt. Ebből 4 állítás a Család alfaktorához, 3 állítás a Barátok alfaktorához és 3 állítás a Jelentős mások alfaktorához tartozik. Az egyes faktorok belső megbízhatósága (Család: Cronbach-α = 0,91; Barátok: Cronbach-α = 0,93; Jelentős mások: Cronbach-α = 0,87) és az egész kérdőív reliabilitása (Cronbach-α = 0,91) megfelelőnek bizonyult. A kérdőív illeszkedési mutatói az elfogadható vagy a jó tartományba estek (CMIN/DF = 5,876; CFI = 0,974; RMSEA = 0,08; GFI = 0,949; TLI = 0,963).

Következtetések
Az MSPSS magyar változata egy érvényes és megbízható mérőeszköz, amely egyrészt mutat összefüggést más, széles körben használt sztenderd kérdőívekkel, másrészt van az észlelt társas támogatás pszichológiai kérdéskörének több olyan szelete, amelyet a korábbi eszközök nem fedtek le, így indokolt az új kérdőív bevezetése.
Salvage Therapy in Advanced Adult Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis of Randomized Trials
Authors: Comandone Alessandro , Petrelli Fausto , Boglione Antonella , Barni Sandro 
Published: August 2017

Abstract

Background
Prognosis for patients with metastatic soft tissue sarcomas (STS) is dismal, with median overall survival (OS) of 8–12 months. The role of second-line therapy has been inconsistently investigated over the last 20 years. This systematic review and meta-analysis was performed to assess the efficacy of salvage treatment in pretreated adult type STS, gastrointestinal stromal tumor (GIST) excluded.

Material and Methods
PubMed, Web of Science, SCOPUS, EMBASE, CINAHL, and The Cochrane Library were searched for randomized phase II/phase III trials exploring second- or beyond therapy lines in pretreated metastatic STS. Two independent investigators extracted data; the quality of eligible studies was resolved by consensus. Hazard ratio (HR) of death and progression (OS and progression-free survival [PFS]) and odds ratio (OR) for response rate (RR) were pooled in a fixed- or random-effects model according to heterogeneity. Study quality was assessed with the Cochrane's risk of bias tool, and publication bias with funnel plots.

Results
Overall, 10 randomized trials were selected. The pooled HR for death was 0.81 (95% confidence interval [CI] 0.73–0.9). Second-line therapy reduced the risk of progression by 49% (HR = 0.51, 95% CI 0.34–0.76). This translated into an absolute benefit in OS and PFS by 3.3 and 1.6 months, respectively. Finally, RR with new agents or chemotherapy doublets translated from 4.3% to 7.6% (OR = 1.78, 95% CI 1.22–2.50).

Conclusion
Better survival is achieved in patients treated with salvage therapies (chemotherapy, as single or multiple agents or targeted biological agents). A 3-months gain in OS and an almost double RR is observed. Second lines also attained a reduction by 50% the risk of progression.

Implications for Practice
There is some evidence that salvage therapies after first-line failure are able to improve outcome in metastatic soft tissue sarcoma (STS). Trabectedin, gemcitabine-based therapy, and pazopanib are currently approved drugs used after conventional upfront treatment. This meta-analysis reviews the benefit of new agents used in randomized trials in comparison with no active treatments or older agents for recurrent/progressed STS. The results show that modern drugs confer a statistically significant 3-month benefit in terms of overall survival, and an increase in response rate. Despite a limited improvement in outcome, currently approved second-line therapy should be offered to patients with good performance status.
Infant mortality in Russian Federation and influence on its dynamic factors
Authors: Ivanov Dmitry O. , Oryol Vasily I. , Alexandrovich Yuri S. , Prometnoy Dmitriy V. 
Published: August 2017

Minimizing infant mortality (IM) is the primary national objective of the Russian Federation.
Aim: This study aimed to analyze IM indicators in the Russian Federation and identify factors that influence the dynamics of IM. The level of leading regional indicators of socioeconomic development and provision by doctors and hospital beds in the Russian Federation was studied and compared with the similar factors in foreign countries.
Materials: Official and operative reports of Rosstat for 2011-2016 were assessed.
Results. The coefficient of IM was 6.0 per 1000 live births in the Russian Federation, and varied from 4.8-9.2 in federal districts. The indicator increased in 2012 in connection with the transition to a new system of newborn registration. The indicator witnessed a permanent decline in 2016 and revealed a negative correlation between the regional bulk products and the coefficient of IM and a positive correlation with the overall IM. However, the relationship among the indicators of IM and the size of the region, the number of highways, the number of patients per one hospital bed or assigned to one doctor could not be established.
Conclusion. In the Russian Federation, IM is higher than that indeveloped countries; has permanent tendency to decline; correlates with regional bulk products; does not depend on transport availability, provision with doctors, and hospital beds; and is determined by the organization and the quality of medical care.
Characteristics of acute period of traumatic brain injury in children with hemophilia
Authors: Guzeva Valentina I , Ochrim Inna V , Maksimova Nadezhda E , Guzeva Oksana V , Guzeva Victoria V , Abramova Natalia N , Rodionov Jurii V 
Published: August 2017

The clinical picture of traumatic brain injury (TBI) in children is characterized by pronounced polymorphism. To clarify the severity of TBI and the localization of the pathological process, use computed tomography (CT) or magnetic resonance imaging (MRI) of the brain.
The aim of the work was to justify the need for neuroimaging to all children with hemophilia with TBI and to determine the correlation between the severity of clinical manifestations and neuroimaging data. The article describes the clinical case of a favorable outcome of an TBI in a toddler child with hemophilia A. The case is of interest to physicians of various specialties and demonstrates the features of the clinical course of acute TBI with hemophilia. The diagnostic process for TBI was based on complaints, clinical and neuroimaging data. Complaints and the circumstances of the injury are known from the mother's words in connection with the early age of the child and the absence of a formed speech. Methods of investigation: collection of complaints and anamnesis of the disease, neurological examinations, laboratory and instrumental data, including neuroimaging data. It is known that the boy fell off the couch, hit the back of the head, did not lose consciousness, there was no vomiting. A day after receiving the injury, there was an increase in cerebral neurological symptoms. Clinically, hematoma is suspected. On the CT of the brain, epidural hematoma was determined. Thus, the presented clinical case illustrates that even a minor head injury in patients with hemophilia can lead to severe consequences. Neuroimaging of the brain with TBI is indicated for all children with hemophilia, regardless of the severity of clinical manifestations.
Impact of post appendectomy pain
Authors: Lamture Yashwant R. , Gajbhiye Varsha P. , Shinde R. K. , Kiran Kher 
Published: August 2017

Background: Appendectomy is one of the commonest abdominal operation performed during emergency hours for acute appendicitis. Acute appendicitis is the common pathology in right lower abdomen. Postoperative complications following appendicectomies are not uncommon and reflect the degree of peritonitis that was present at the time of operation. Intra operative spillage and intercurrent diseases that may predispose to the complication. But all patients are not relieved of their symptoms following surgery. Few patients continue to visit surgical OPD for continuous pain in right iliac fossa even after appendectomy had been performed. So, we design proforma to find out exact cause of pain. This study is a sincere effort on our part to solve secrets of post appendectomy pain.Methods: Evaluation of patient who continue to visit even after removal of appendix for pain in right iliac fossa. It was tried to establish correlation between relief of pain and histopathology report of appendix to justify the appendicectomies. These patients investigated to find out underlying organic cause. Functional patients were subjected for psychological evaluation.Results: In present study from June 2006 to August 2008 we enrolled around 30 patients with complaints of pain in right iliac fossa even after appendectomy. 60% were female and 40% were male in a present study. Out of 30 cases 24 patient means 80%, were in the age group of 20 to 40 years. We found one patient means 3.33% with clinical diagnosis of stump appendicitis on radiological (barium meal follows through) examination was confirmed who responded to conservative line of treatment. All patients presented with pain in right iliac fossa symptom was the criteria for selection of patients. Exception of single patient of stump appendicitis rest were having other treatable causes.Conclusions: Out of 30 patients only one patient was having actual stump appendicitis. It is not correct to say that post appendectomy pain is a complication of surgical procedure, as multiple treatable causes were found in 29 patients. Study demonstrated that most of these patients really had organic disease. Only two patients were simple victims of psychosomatic pain. This study enlightened nicely regarding various delayed complications of appendectomy.
Complications of laparoscopic cholecystectomy: an analysis of 1,695 laparoscopic operations
Authors: Jatothu Dasharadha , Sade Rajkumar , Sade Kirthana , Taruni . , Pyadala Nagababu 
Published: August 2017

Background: Laparoscopic cholecystectomy (LCs) is the gold standard method to treat gallstone disease. But there are some complications which occur frequently as compared to open cholecystectomy.Methods: The prospective study was conducted in the Department of Surgery, Kamineni Institute of Medical Sciences, Telengana during the period of 2 years; March 2015 to February 2017. A total of 1,695 laparoscopic cholecystectomy cases were included in this study. Several treatment options such as, conservative treatment, minimally invasive treatment and open surgery was performed based on the severity of the disease.Results: Majority of patients were female (83.9%) and most common age group affected was above 40 years. Intra-operative and post-operative complication occurred in 4.5% and 1.9% patients respectively. Majority complications were treated by conservative treatment and minimally invasive treatment. So, in conclusion, we can use conservative and minimally invasive treatment to manage the complications from laparoscopic cholecystectomy.Conclusions: Conservative treatment options and minimally invasive treatment was more efficient to overcome the post-operative complication of laparoscopic cholecystectomy.
CONCEITOS, NORMAS E NÚMEROS: UMA INTRODUÇÃO À EDUCAÇÃO ESCOLAR QUILOMBOLA
Authors: Arruti José Maurício Andion 
Published: August 2017

<span style="color: #222222; line-height: 150%; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: PT-BR; mso-fareast-language: PT-BR; mso-bidi-language: AR-SA;">Este texto tem por objetivo introduzir o leitor na temática da “educação quilombola” por meio da apresentação dos seus conceitos básicos, das políticas públicas a eles relacionadas e, finalmente, dos números oficiais relativos à alfabetização da população quilombola e às escolas situadas em territórios quilombolas. No trato dos números, estabelecemos uma primeira comparação com as categorias de “educação escolar indígena” e de “escolas rurais”. Trata-se de uma aproximação do tema por meio da definição dos seus contornos mais largos, indo do conceitual ao quantitativo, passando pelo normativo.</span>
ANALISA FAKTOR – FAKTOR YANG BERPENGARUH TERHADAP KETEPATAN WAKTU PELAPORAN KEUANGAN (STUDI EMPIRIS PADA PERUSAHAAN OTOMOTIF DAN KOMPONEN DAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA)
Authors: Suryanto Joko , Pahala Indra 
Published: August 2017

This research aims to examine the effect of the relationship between firm size, profitability, solvency, public ownership, and the audit opinion on the timeliness of financial reporting. The dependent variable in the form of timekeeping company deliver the financial statements to the Stock Exchange. Meanwhile for the independent variables such as firm size measured by total asets of the company, profitability is measured by profit margin ratio, solvency measured by debt-to-equity ratio, public ownership is measured by the percentage of the number of shares owned by the community, and the audit opinion is measured with an unqualified opinion and otherwise unqualified. This study uses secondary data with population automotive companies and telecommunications components and annual financial statements issued on the Stock Exchange in the period 2010-2012. From the analysis conducted in this study it can be concluded that the size of the company significantly influence the timeliness of financial reporting. While profitability, solvency, public ownership, and the audit opinion does not affect the timeliness of financial reporting.

Keywords: Company Size, Profitability, Solvency, Public Shareholding, Opinion Audit and Financial Reporting Timeliness.
KAJIAN PENILAIAN ASPEK NON-KOGNITIF SISWA DI PESANTREN AS-SUNNAHDALAM KEGIATAN PRAKTIKUM IPA POKOK BAHASAN SISTEM PENCERNAAN PADA MANUSIA
Authors: Gloria Ria Yulia 
Published: August 2017

Salah satu upaya untuk meningkatkan kualitas siswa dan ketertarikan siswa pesantren khususnya pada pelajaran IPA diantaranya adalah dengan mengadakan praktikum.Hal ini sesuai dengan pendapat Arends (2008), bahwa belajar yang baik adalah bila anda terlibat secara pribadi dalam pengalaman belajarnya (experiential Learning). Maka dilakukan penelitian dengan rumusan masalah bagaimanakah kegiatan dan kajian kemampuan non-kognitif siswa pesantren As-Sunnah dalam kegiatan praktikum uji makanan pada materi pencernaan makanan pada manusia. Hal ini bertujuan untuk mengkaji kegiatan praktikum di pesantren As-Sunnah dan mengkaji kemampuan non-kognitif siswa. Penelitian ini dilakukan di pesantren As-Sunnah dengan metode penelitian deskriptif kualitatif dan deskriptif inquiry. Hasil penelitian diperoleh sebagai beri- kut bahwa kegiatan praktikum di pesantren As-Sunnah yaitu di MTs Kelas VII putri jarang dilakukan karna beberapa kendala salah satunya adalah kendala sarana dan prasarana terutama ketersediaan laboratorium, namun demikian kegiatan praktikum masih tetap bisa dijalankan di ruang belajar (kelas). Untuk kajian non kognitif didapatkan kesimpulan, tingkat kesiapan siswa dalam melakukan praktikum cukup baik, keterampilan siswa dalam praktikum termasuk kedalam kategori cukup kompeten, sikap siswa sangat baik dalam kegiatan praktikum yang terdiri dari kerjasama, kedisiplinan, ketelitian, dan tanggung jawab. Sedangkan untuk respon terhadap kegiatan praktikum dapat disimpulkan bahwa siswa memiliki rasa ingin tahu terhadap hasil praktikum cukup besar, yaitu 77,8%.
Control systems for olive mill wastewater treatment with ultrafiltration and nanofiltration membrane in series based on the boundary flux theory
Authors: Ochando-Pulido Javier Miguel 
Published: August 2017

Abstract
Proper membrane process design can be a difficult task to accomplish when fouling is present, and must be faced. Engineers usually consider the project variables concerning productivity and selectivity and follow these targets. However, in the presence of fouling, additional parameters must be considered, implying better knowledge of fouling phenomena. One possible solution to increase the reliability of a process is the use of stable control systems. This article reports a suitable method to reach this target, based on the boundary flux theory. The knowledge of the boundary flux values permits avoidance of high fouling operating conditions on a selected membrane. The goal here was to determine the framework for control of an ultrafiltration (UF) and nanofiltration (NF) batch membranes-in-series process treatment for olive mill wastewater, relying on these boundary flux points, which will thereafter serve for the automatic control of the process by an advanced control system. In this work, boundary flux values equal to 10 Lh−1m−2 for the UF membrane module and 14.3 Lh−1m−2 for the NF one were estimated. Moreover, the membrane constant permeability loss, measured by integrating the sub-boundary fouling index, was estimated to be reduced in the order of 65.4% for the NF membrane after the applied pretreatment and UF. This strategy permitted attaining stable and constant productivity for both membranes. Moreover, it is shown that, relying on the boundary flux modelization, both types of control systems (feed control and pressure control) could be used reliably. The proposed approach could help safely narrow the overdesign of membrane processes due to fouling issues and thus would have an impact on the reduction of the costs for both membrane processes.
The Effect of an Enrichment Program in Life and Natural Sciences Module in Developing Achievement Motivation: An Experimental Study on Students of 1st Secondary Grade
Authors: Omar Jaidja , Mansour Hamel 
Published: August 2017

This study aimed to test the effect of an enrichment program in a unit of science of nature and life on achievement motivation. The sample of this study consisted of 71 students (41 males and 29 females) enrolled in the new secondary school in Ouanougha, Algeria. This sample was devided into two groups: the experimental group (N=33), and the control group (N=38). To realise the aim of the study, an enrichment program was developed. The program was applied during the 3rd term of the school year 2012/2013. A measure of achievement motivation was developed. The results indicated a significant difference in favoe of the experimmenttal group over the control group both in each of the subscales and the total scale of motivation.