bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of a controlled study of levosimendan combined with Sacubitril/Valsartan for the treatment of heart failure with reduced ejection fraction in China
Authors: Li Che , Zheng Jifeng , Zhang Bin , Xu Jianjiang , Chu Zhenliang 
Published: October 2024

ObjectiveLevosimendan and Sacubitril/Valsartan are both potent pharmacotherapeutic agents in the clinical management of heart failure characterized by reduced ejection fraction. However, the limited efficacy of monotherapy and the lack of extensive clinical experience with combination therapy necessitate further investigation. This study aimed to evaluate the therapeutic effects of combining levosimendan with sacubitril/valsartan on chronic heart failure with reduced ejection fraction, specifically through a meta-analysis of studies conducted in China.MethodsCochrane systematic evaluation method was used to complete data retrieval from the following related databases: (1) Wanfang database; (2) CNKI China Academic Journal Network; (3) Wipo Full-text Database of Chinese Sci-tech journals; (4) PubMed; (5) Medline; (6) Chinese Biomedical Literature Database; (7) Web of Science; and (8) Google Scholar database. We searched for studies published up to December 2021. Data were extracted from applicable articles. Meta-analyses were performed to assess the left ventricular ejection fractions (LVEF) level, NT-proBNP level, Clinical efficacy, and the left ventricular end-diastolic dimension (LVEDD) level outcomes, following PRISMA 2020 guidelines.ResultsA total of five randomized controlled trials (RCTs) comprising 398 patients were included, half of the patients for levosimendan combined with Sacubitril/Valsartan and half of the patients for control groups. The effective rate in experimental group was significantly higher than that in control group [Peto-OR = 3.08, 95% CI (1.83, 5.19), P &lt; 0.05]. The LVEF level after treatment in the experimental group was significantly higher than that in the control group [MD = 5.51, 95% CI (4.25, 6.76), P &lt; 0.05]. After treatment, the LVEDD level in the experimental group was lower than that in the control group [MD = −3.83, 95% CI (−7.60, −0.05), P &lt; 0.05]. There was a statistically significant difference in the N terminal pro B type natriuretic peptide (NT-proBNP) level between the two groups after treatment, where the value for the experimental group was lower than that for the control group [SMD = −2.68, 95% CI (−3.94, −1.43), P &lt; 0.05].ConclusionMeta-analysis results showed that levosimendan combined with Sacubitril/Valsartan has a better therapeutic effect on heart failure with reduced ejection fraction and is beneficial for improving cardiac function. The main mechanism for this may be related to the pharmacological action of levosimendan.
Are school grades correlated with competencies in secondary school pupils with special needs?
Authors: Lange-Kuettner Christiane 
Published: October 2024

IntroductionThe current correlative study investigates whether and to what extent school grades are related to competencies in adolescents with and without special educational needs and disabilities (SEND) in inclusive secondary education.MethodsA sample of N = 2,998 adolescents with a mean age of 12 years were longitudinally assessed in German language and Mathematics in a nationwide project on inclusive schooling in Germany in 2018/19 (T1) and 2019/20 (T2) in secondary school. The hypothesis was that competencies and school grades should be significantly correlated in both adolescents with and without SEND, showing the reliability of school grades for either group.Results and discussionStatistical analyses showed (1) all adolescents improved their competencies independently of their SEND status while school grades were moderately stable over time, (2) more variability of competencies and school grades emerged only at the tail ends of the scales of fail and best scores, (3) correlations between competencies and grades were consistently higher in mathematics than in German language for both pupils with and without SEND indicating a more objective and reliable measure.
Knowledge mapping and visualization of trends in immunotherapy for ovarian cancer over the past five years: a bibliometric analysis
Authors: Shaie Kowthar Mohamed , Sihan Lian , Yuli Wang , Mengfei Han , Renqian Feng , Yan Hu 
Published: October 2024

BackgroundThis study conducts a bibliometric literature analysis to explore trends in immunotherapy for ovarian cancer from 2019 to 2023.MethodsAn extensive online literature search was conducted in the Web of Science Core Collection database to identify English-language articles and reviews related to “trends in immunotherapy”, and “ovarian cancer”. statistical analysis was performed using VOSviewer to visualize and compare nations, institutions, and journals simultaneously.ResultsOur findings highlight contributions by 118 nations, led by the People’s Republic of China with 3,167 contributions; Germany followed with 558 and Italy having 547. Of all publications made between 2019-2023, “Frontiers Immunology” had the most publications with 546 total records followed by “cancers “, and “frontiers in oncology” being the most heavily relied upon categories. Annually publication trends increased until 2022 but then declined considerably as a peak of highly-cited papers occurring between 2019 and 2022.ConclusionsOur bibliometric analysis not only maps the evolution of immunotherapy research in ovarian cancer but also provides actionable insights for advancing scientific progress. By identifying emerging trends and key areas, future research can strategically enhance treatment strategies and outcomes for ovarian cancer patients.
Severe allergic rash induced by icodextrin: case report and literature review
Authors: Huang Yiqi , Fu Tianxiao , Zhang Yanling , Shen Weigang , Sang Weiwei , Han Meixiang , Wang Fang , Chen Fenjuan 
Published: October 2024

BackgroundIcodextrin is a type of peritoneal dialysis (PD) osmolyte that can be extended retention times (8–16 h) and may offer a viable alternative to conventional glucose dialysis solutions for PD patients. Nonetheless, prolonged use of icodextrin may lead to allergic rash, and rarely severe skin lesions.Case presentationIn February 2024, a 45-year-old male was admitted to the Department of Nephrology at Shaoxing Second Hospital presenting with a 3-day history of intense generalized pruritic erythematous rash. Physical examination revealed diffuse erythematous pruritic rash and exfoliative rash, particularly on the abdominal. Abnormal laboratory findings included elevated eosinophil count and total IgE levels, indicative of an allergic rash. Standard anti-allergic regim was initiated. However, on the third day in the hospital, the patient developed new pustules on his neck and arms. Subsequent historical investigation uncovered that the individual had previously administered icodextrin 2 weeks prior due to volume overload, and the last intraperitoneal administration time was second day of hospitalization. The dermatologist rendered a diagnosis of generalized exfoliative rash and acute localized exanthematous pustulosis (ALEP) induced by icodextrin, and initiated prophylactic antimicrobial therapy accordingly. Furthermore, the patient declined to undergo a skin biopsy. Noteworthy is the observation that the rash ameliorated and the pustules resolved by the seventh day post-admission. Presently, the patient is still under clinical follow-up.ConclusionThis article aims to report the first case of severe allergic rash caused by icodextrin in Chinese PD patients and highlight the potential for icodextrin to trigger ALEP. A literature review of similar cases found that severe allergic rash induced by icodextrin is rare, the underlying mechanism remains poorly understood, and the prognosis is positive with proper treatment.
Metabolomics of 3D cell co-culture reveals alterations in energy metabolism at the cross-talk of colorectal cancer-adipocytes
Authors: Pelosi Andrea Corazzi , Silva Alex Ap. Rosini , Fernandes Anna Maria Alves Piloto , Scariot Pedro Paulo Menezes , Oliveira Manoela Stahl Parisotto , Porcari Andreia M. , Priolli Denise Gonçalves , Messias Leonardo Henrique Dalcheco 
Published: October 2024

IntroductionColorectal cancer (CRC) is the third most incident and the second most lethal malignant tumor. Despite the recognized association between obesity and CRC, further clarification is necessary regarding the lipids that are overexpressed during the development of CRC. In this scenario, the combination of metabolomics and a three-dimensional (3D) co-culture model involving CRC tumor cells and lipids can enhance the knowledge of energy metabolism modifications at the cross-talk between colorectal cancer and adipocytes. This study aimed to screen potential metabolites in the three dimensional (3D) co-culture of CRC and adipocytes by investigating the metabolome composition of this co-culture released into the extracellular space, which is known as the secretome.MethodsPre-adipocyte cells (3T3-L1), human colon carcinoma (HT-29), and the 3D co-culture (3T3-L1 + HT-29) were cultured for the secretome obtention. Then, ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) was employed to analyze the metabolomics of each secretome.ResultsOverall, 3.731 molecules were detected independent of the cell culture. When comparing the three cultures, 105 molecules presented a statistically significant difference in abundance between groups. Among these molecules, 16 were identified, with a particular emphasis on six lipids (PG 20:0, octadecenal, 3-Hydroxytetracosanoyl-CoA, 9,10-dihydroxy-octadecenoic acid, palmitoleic acid, and PA 18:4) and one amino acid derivative (acetylglutamic acid), which presented significant scores during the partial least-squares discriminant analysis (PLS-DA).DiscussionAlthough it is too early to determine the possible impact of such molecules in a CRC microenvironment, these results open new avenues for further studies on the energy metabolism at the cross-talk of colorectal cancer adipocytes.
Psychological factors and biochemical indicators influencing sleep disturbance of patients with primary biliary cholangitis in China: a cross-sectional survey analysis
Authors: Zhao Chenyang , Zang Bo , Liu Qixuan , Liu Bingqian , Yao Yuan , Li Hua , Yang Yifei , Liu Bin 
Published: October 2024

ObjectiveThe impact of primary biliary cholangitis (PBC) on sleep disturbance is relevant to treatment decision-making processes. Studies on sleep disturbance in Chinese patients with PBC are still lacking.MethodsWe analyzed and compared the health-related quality of life (HRQoL) of 107 PBC patients by using the Pittsburgh Sleep Quality Index (PSQI) questionnaire, Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire 9 (PHQ-9), Short Form (36) Health Survey Questionnaire (SF-36), Fatigue Visual Analog Scale (F-VAS). Patients’ biochemical markers were also collected for correlation analysis with HRQoL. Receiver operating characteristic (ROC) curves and area under the curve (AUCs) were used to determine the diagnostic performance of PSQI, GAD-7, and biochemical markers for assessing the impaired liver function (Child–Pugh B–C) of PBC diagnosis.ResultsSixty-two (57.9%) PBC patients suffered from poor sleep quality (PSQI &gt;5). The global PSQI score was positively correlated with GAD-7 (r = 0.561, p &lt; 0.001), and PHQ-9 scores (r = 0.652, p &lt; 0.001). There was a negative correlation (r = −0.216, p = 0.025) between sleep quality and red blood cell (RBC) count. PBC patients with poor sleep quality had significantly higher GAD-7 scores (5 vs. 0, p &lt; 0.001), PHQ-9 scores (5.5 vs. 0, p &lt; 0.001), and lower albumin levels (39.6 vs. 37.6 g/L, p = 0.040) than those with good sleep quality. Based on the SF-36 scores, PBC patients with poor sleep quality had lower physical functioning scores (85 vs. 80, p = 0.022), role physical scores (100 vs. 75, p = 0.007), and worse mental health (60 vs. 56, p = 0.002) than those with good sleep quality. ROC analyses showed that the AUC and optimal cut-off values of the combination of PSQI, GAD-7, and RBC for assessing the impaired liver function in PBC diagnosis were 0.771 and 0.193, respectively.ConclusionThe sleep disturbance was strongly correlated with the severity of anxiety, depression, and RBC count in PBC patients. Meanwhile, PBC patients with poor sleep had poor HRQoL and lower albumin levels. It is feasible to use the combination of PSQI, GAD-7, and RBC for initial screening of the impaired liver function in PBC. Besides routine blood biochemical and imaging indicators, evaluating mental health-related indicators in PBC patients is imperative.
A bibliometrics and visualization analysis of ropivacaine research from 2000 to 2023
Authors: Zhang Jian , Liu Ye , Gu Xiyao , Chai Jing 
Published: October 2024

AimBibliometric and data visualization methods were used to identify the current status, key areas, and emerging frontiers in ropivacaine research.MethodsWe conducted a comprehensive search of the Web of Science database for publications related to ropivacaine published from 2000 to 2023. The publication types were limited to original articles and reviews. We utilized CiteSpace, VOSviewer, and the online bibliometric platform1 to visualize and analyze the collected data.ResultsA total of 4,147 publications related to ropivacaine were identified, with a consistent growth in annual publications over time. The United States emerged as the most influential country in the field of ropivacaine research, and ranked first in the annual number of publications until 2014. China surpassed the United States in the number of publications for the first time in 2015 and has remained in first place ever since. Of all the research institutions in the field of ropivacaine, University of Copenhagen in Denmark exhibited the highest impact. Brian M. Ilfeld and Casati A were identified as the most influential authors. The leading researchers in this field primarily focused their publications on continuous nerve blocks for postoperative analgesia and ultrasound-guided nerve block techniques. An analysis of reference co-citation clustering revealed 18 distinct research clusters, with current hotspots including erector spinae plane block, dexmedetomidine, quadratus lumborum block, labor analgesia, and mitochondrial respiration. Additionally, keywords analysis indicated that “dexmedetomidine as an adjuvant in nerve blocks” currently represents a research hotspot in the field of ropivacaine.ConclusionThis bibliometric analysis provides a comprehensive overview of the research landscape in ropivacaine. It reveals research trends in this field and emerging areas for future investigations. Notably, the application of ropivacaine in nerve blocks is a prominent focus in current research, with a particular emphasis on its combination with dexmedetomidine.
Concurrent chronic kidney disease in patients with inflammatory bowel disease, a systematic review and meta-analysis
Authors: Han Xiaoping , Xu Zifeng , Chang Yu , Li Hongyan , Hu Sileng , Chang Shiyu , Liu Yue , Yu Chanjiao , Tang Tongyu , Li Yuqin 
Published: October 2024

IntroductionInflammatory bowel disease (IBD) is a multi-organ autoimmune disease that commonly affects the gastrointestinal tract, but can also affect other organs throughout the body. Less is known, however, about kidney involvement in IBD. Although IBD has been associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD), these results have been inconsistent. The present study analyzed the prevalence of concurrent CKD and ESRD in patients with IBD.MethodsPubMed, Cochrane, Web of Science, and Embase were searched for studies published through October 2023 on IBD patients with concurrent CKD or ESRD. Outcomes included the incidence rates and odds ratios (OR) of concurrent CKD and ESRD in IBD patients. The quality of included studies was assessed using the Newcastle-Ottawa Scale, and sequential sensitivity was analyzed. Publication bias was evaluated using Egger’s test.ResultsNine studies were included in this meta-analysis. The combined results of eight studies, which included 239,042 IBD patients, showed that the prevalence of CKD in IBD patients was 5% (95% confidence interval [CI]: 1–9%). The combined results of two studies, which included 40,341 IBD patients, showed that the prevalence of ESRD in IBD patients was 0.2% (95% CI: −0.08–0.12%). The combined results of six case–control studies reported that the risk of CKD was significantly higher in patients with than without IBD (OR 1.36, 95% CI: 1.08–1.70, p = 0.008).ConclusionAlthough studies have shown an increased risk of CKD in IBD, due to the small number of included studies and high heterogeneity across studies, it is not enough to definitively conclude that CKD is more common in patients with IBD. But patients with IBD should be regularly monitored for CKD.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/.
Systolic blood pressure variability in late-life predicts cognitive trajectory and risk of Alzheimer’s disease
Authors: Li Xiao-Lu , Wang Ruo-Tong , Tan Chen-Chen , Tan Lan , Xu Wei 
Published: October 2024

BackgroundThe relationship of systolic blood pressure variability (SBPV) with Alzheimer’s disease (AD) remains controversial. We aimed to explore the roles of SBPV in predicting AD incidence and to test the pathways that mediated the relationship of SBPV with cognitive functions.MethodsLongitudinal data across 96 months (T0 to T4) were derived from the Alzheimer’s disease Neuroimaging Initiative cohort. SBPV for each participant was calculated based on the four measurements of SBP across 24 months (T0 to T3). At T3, logistic regression models were used to test the SBPV difference between 86 new-onset AD and 743 controls. Linear regression models were used to test the associations of SBPV with cognition and AD imaging endophenotypes for 743 non-demented participants (median age = 77.0, female = 42%). Causal mediation analyses were conducted to explore the effects of imaging endophenotypes in mediating the relationships of SBPV with cognitive function. Finally, Cox proportional hazard model was utilized to explore the association of SBPV with incident risk of AD (T3 to T4, mean follow-up = 3.5 years).ResultsParticipants with new-onset AD at T3 had significantly higher SBPV compared to their controls (p = 0.018). Higher SBPV was associated with lower scores of cognitive function (p = 0.005 for general cognition, p = 0.029 for memory, and p = 0.016 for executive function), higher cerebral burden of amyloid deposition by AV45 PET (p = 0.044), lower brain metabolism by FDG PET (p = 0.052), and higher burden of white matter hyperintensities (WMH) (p = 0.012). Amyloid pathology, brain metabolism, and WMH partially (ranging from 17.44% to 36.10%) mediated the associations of SBPV with cognition. Higher SBPV was significantly associated with elevated risk of developing AD (hazard ratio = 1.29, 95% confidence interval = 1.07 to 1.57, p = 0.008).ConclusionThese findings supported that maintaining stable SBP in late life helped lower the risk of AD, partially by modulating amyloid pathology, cerebral metabolism, and cerebrovascular health.
Genetic insights into dietary patterns, liposome mediation, and osteoporosis risk: a Mendelian randomization study
Authors: Long Kehan , Zheng Tengfei , Gong Ao , Ying Zhendong , Zhang Lei 
Published: October 2024

BackgroundThis study examines the indirect causal relationships between dietary habits and osteoporosis, mediated through liposomes, utilizing a two-sample Mendelian randomization (MR) approach. The research leverages genetic variations as instrumental variables to explore the genetic influences on dietary habits, liposomes, and osteoporosis, aiming to unravel the complex interplay between diet, lipid metabolism, and bone health.MethodsThe study utilized genome-wide association studies (GWAS) data for liposomes from Finnish individuals and osteoporosis-related data, alongside dietary factors from the OpenGWAS database. Instrumental variables were selected based on genetic variants associated with these factors, using a strict significance level and linkage disequilibrium threshold. Statistical analysis employed the Inverse Variance Weighted method, weighted median, and mode-based methods within the R environment, complemented by sensitivity analyses to ensure the robustness of the causal inferences.ResultsFindings revealed significant causal relationships between specific dietary components (white rice, cereal, and non-oily fish) and osteoporosis risk, both directly and mediated through changes in liposome levels. Notably, white rice consumption was associated with an increased risk of osteoporosis, while cereal and non-oily fish intake showed protective effects. Further, certain liposomes were identified as mediators in these relationships, suggesting a link between diet, lipid profiles, and bone health.ConclusionThe study highlights the significant impact of dietary habits on osteoporosis risk, mediated through liposomes. These findings underscore the importance of considering lipidomic profiles in dietary guidance and suggest potential targets for preventing osteoporosis through nutritional interventions.
Association between dietary vitamin B6 intake and endometriosis risk: evidence from the national health and nutrition examination survey
Authors: Yin Ling , Liang Feng , Xie Baoli , Su Yanlin , Cheng Li , Wei Xin , Tian Wencai 
Published: October 2024

BackgroundEndometriosis is a multifaceted disorder with genetic, immune, inflammatory, and multifactorial origins. Vitamin B6 serves as a pivotal coenzyme in various metabolic pathways involving lipids, hemes, nucleic acids, proteins, and carbohydrates. Dysregulation or deficiency of vitamin B6 can perturb human physiology. However, the relationship between dietary vitamin B6 and endometriosis remains elusive. This study aims to explore how dietary intake of vitamin B6 is associated with the risk of endometriosis.MethodsUsing cross-sectional data from the National Health and Nutrition Examination Survey, we analyzed information from American women aged 20–54 years between 1999 and 2006. After adjusting for relevant covariates, multivariable logistic regression analysis was employed to evaluate correlations.ResultsA total of 4,453 women were included in the study. The multiple linear regression model revealed a positive association between dietary vitamin B6 intake and the risk of endometriosis, even after controlling for confounding variables. Compared to individuals with lower vitamin B6 consumption (Q1: &lt;0.94 mg/day), the adjusted odds ratio (OR) values for dietary vitamin B6 intake and endometriosis in Q2 (0.95–1.39 mg/day), Q3 (1.40–1.99 mg/day), and Q4 (&gt;1.90 mg/day) were 1.22 (95% CI: 0.88–1.69, p = 0.23), 1.22 (95% CI: 0.86–1.73, p = 0. 279), and 1.51 (95% CI, 1.01–2. 24, p = 0.04), respectively.ConclusionOur findings suggest a positive correlation between endometriosis and dietary vitamin B6 intake. Further investigations are imperative to establish a causal relationship between dietary vitamin B6 intake and endometriosis.