bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Human Cytoplasmic Dynein Interactome Reveals Novel Activators of Motility
Authors: Redwine William B. , DeSantis Morgan E. , Hollyer Ian , Htet Zaw Min , Tran Phuoc Tien , Swanson Selene K. , Florens Laurence , Washburn Michael P. , Reck-Peterson Samara L. 
Published: May 2017

ABSTRACTIn human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends. To understand how a single motor achieves cargo specificity, we identified the human dynein interactome or “transportome” by attaching a promiscuous biotin ligase (“BioID”) to seven components of the dynein machinery, including a subunit of the essential cofactor dynactin. This method reported spatial information about the large cytosolic dynein/dynactin complex in living cells. To achieve maximal motile activity and to bind its cargos, human dynein/dynactin requires “activators”, of which only five have been described. We developed methods to identify new activators in our BioID data, and discovered that ninein and ninein-like are a new family of dynein activators. Analysis of the protein interactomes for six activators, including ninein and ninein-like, suggests that each dynein activator has multiple cargos.
Anticipating emerging arboviruses: What comes after Zika?
Authors: Evans Michelle V. , Murdock Courtney C. , Drake John M. 
Published: May 2017

AbstractNew vector-borne diseases have emerged on multiple occasions over the last several decades, raising fears that they may become established within the United States. Here, we provide a watchlist of flaviviruses with high potential to emerge in the US, identified using new statistical techniques for mining the associations in partially observed data, to allow the public health community to better target surveillance.
Masculinity and the mechanisms of human self-domestication
Authors: Gleeson Ben Thomas 
Published: May 2017

AbstractObjectivesPre-historic decline in human craniofacial masculinity has been proposed as evidence of selection for elevated sociability and a process of ‘human self-domestication’ thought to have promoted complex capacities including language, culture, and cumulative technological development. This follows experimental observation of similar changes in non-human animals under selection for reduced aggression. Two distinct domestication hypotheses posit developmental explanations, involving hypoplasia of embryonic neural crest cells (NCCs), and declining androgen influence, respectively. Here, I assess the operation and potential interactions between these two mechanisms and consider their role in enhanced human adaptation to a cooperative sociocultural niche.MethodsI provide a review and synthesis of related literature with a focus on physiological mechanisms effecting domesticated reductions in masculinity and sexual dimorphism. Further, I examine pre-historic modes of socio-sexual selection likely to drive human self-domestication via reduced aggression and masculinity.ResultsI find pluripotent NCCs provide progenitors for a wide range of vertebrate masculine features, acting as regular targets for sexually driven evolutionary change; suggesting domesticated hypoplasia of NCC-derived tissues would be sufficient to explain declines in masculine traits and features. However, lineage specific androgen receptor variability likely moderates these NCC-based effects.ConclusionsThese findings extend theorised mechanisms driving noted physiological, morphological, and behavioural changes thought to indicate enhanced sociability and human and self-domestication. Multiple current explanations for human sociability are consistent with physiological domestication under socio-sexual selection favouring dampened masculine physiology and behaviour as adaptations to an enhanced sociocultural niche. The analysis highlights multiple avenues for further investigation.
Local signals in mouse horizontal cell dendrites
Authors: Chapot Camille A. , Behrens Christian , Rogerson Luke E. , Baden Tom , Pop Sinziana , Berens Philipp , Euler Thomas , Schubert Timm 
Published: May 2017

SummaryThe mouse retina contains a single type of horizontal cell, a GABAergic interneuron that samples from all cone photoreceptors within reach and modulates their glutamatergic output via parallel feedback mechanisms. Because horizontal cells form an electrically-coupled network, they have been implicated in global signal processing, such as large scale contrast enhancement. Recently, it has been proposed that horizontal cells can also act locally at the level of individual cone photoreceptors. To test this possibility physiologically, we used two-photon microscopy to record light stimulus-evoked Ca2+signals in cone axon terminals and horizontal cell dendrites as well as glutamate release in the outer plexiform layer. By selectively stimulating the two mouse cone opsins with green and UV light, we assessed whether signals from individual cones remain “isolated” within horizontal cell dendritic tips, or whether they spread across the dendritic arbour. Consistent with the mouse‘s opsin expression gradient, we found that the Ca2+signals recorded from dendrites of dorsal horizontal cells were dominated by M- and those of ventral horizontal cells by S-opsin activation. The signals measured in neighbouring horizontal cell dendritic tips varied markedly in their chromatic preference, arguing against global processing. Rather, our experimental data and results from biophysically realistic modelling support the idea that horizontal cells can process cone input locally, extending the “classical” view of horizontal cells function. Pharmacologically removing horizontal cells from the circuitry reduced the sensitivity of the cone signal to low frequencies, suggesting that local horizontal cell feedback shapes the temporal properties of cone output.HighlightsLight-evoked Ca2+signals in horizontal cell dendrites reflect opsin gradientChromatic preferences in neighbouring dendritic tips vary markedlyMouse horizontal cells process cone photoreceptor input locallyLocal horizontal cell feedback shapes the temporal properties of cone outputeTOC BlurbChapot et al. show that local light responses in mouse horizontal cell dendrites inherit properties, including chromatic preference, from the presynaptic cone photoreceptor, suggesting that their dendrites can provide “private” feedback to cones, for instance, to shape the temporal filtering properties of the cone synapse.
Measuring the impact of beliefs on luxury buying behavior in an emerging market
Authors: Jain Sheetal , Khan Mohd Naved 
Published: May 2017

Purpose
Demand for luxury brands is increasing at a very fast pace in emerging markets like India. But very few quantitative studies have been conducted to explore the reasons behind this sudden surge in demand. Thus, the purpose of this paper is to understand the impact of beliefs on consumer buying behavior for luxury fashion brands in the Indian context employing theory of planned behavior and to develop a comprehensive understanding regarding motivating factors behind luxury goods consumption.

Design/methodology/approach
Researcher-controlled sampling techniques (judgment and snowball sampling) were employed to collect data from actual users of luxury fashion brands in New Delhi (India). Statistical tests including confirmatory factor analysis and structural equation modeling were applied for data analysis.

Findings
The findings show that all three beliefs – attitudinal belief, normative belief (NB) and control belief – were positively and significantly related to attitude, subjective norm and perceived behavioral control (PBC). NB was found to have a positive impact on PBC as well as actual consumer purchasing behavior for luxury fashion brands.

Originality/value
This research contributes to the extant literature by bringing to light new findings that could help provide meaningful insights to the academicians and marketing practitioners.
Online customer relationship marketing tactics through social media and perceived customer retention orientation of the green retailer
Authors: Kang Ju-Young M. , Kim Jieun 
Published: May 2017

Purpose
Despite the importance of incorporating social media with customer relationship management (CRM), the implementation of social CRM is still in its initial stages for a majority of green brands. The purpose of this paper is to examine whether consumers’ perception-based factors of the online CRM tactics through social media (i.e. perceived marketer-dominated information quality, perceived interaction quality, and perceived service content quality in social media) offered by the green brand were related to the perceived customer retention orientation (CRO) of the green fashion retailer, which was related to patronage intention towards the green retailer, and the moderating effect of green consciousness on the link between perceived CRO of the green retailer and patronage intention.

Design/methodology/approach
Data were collected from social media users (n=631) using a consumer panel via an online survey. Structural equation modelling was employed to test the proposed model and research hypotheses.

Findings
This study found that the perceived CRO of the green retailer was positively related to patronage intention. The perceived marketer-dominated information quality and perceived service content quality in social media were positively related to the perceived CRO of the green retailer. Green consciousness moderated the link between perceived CRO and patronage intention.

Originality/value
First, this study contributes to the further theoretical understanding of the underlying factors that influence customer perception of the CRO of the green retailer and green patronage intention. Second, on a managerial level, this proposed model provides green retailers with beneficial insights into the development of successful social CRM.
Risk of impaired cognition after prenatal exposure to psychotropic drugs
Authors: Wibroe M. A. , Mathiasen R. , Pagsberg A. K. , Uldall P. 
Published: May 2017

ObjectivePrenatal exposure to psychotropic drugs may affect the trajectories of brain development. In a register study, we investigated whether such exposure is associated with long‐term impaired cognitive abilities.MethodIndividuals born in Denmark in 1995–2008 were included. As proxies for cognitive impairment, requiring special needs education, attending special needs school, diagnoses of neurological/mental disorder, missed final examinations, and low school grade average were used. We accounted for maternal confounders.ResultsWe identified 868 159 individuals of whom 13 983 (1.6%) were prenatally exposed. The adjusted odds ratio (OR) was 0.97[0.92–1.02] for requiring special needs education, 1.28[1.14–1.43] for attending special needs school, 1.32[1.20–1.46] for a neurological/mental disorder diagnosis, 1.37[1.22–1.54] for missing the final examinations, and 1.13[0.82–1.55] for obtaining a low school grade average. Exposure to psycholeptics (primarily antipsychotics and sedatives) was correlated with significantly increased risk for four outcomes. The highest was the risk of missing the primary school examinations (OR: 1.51[1.29–1.76]). The overall highest risk concerned the presence of a neurological/mental disorder after prenatal exposure to psychoanaleptics (primarily antidepressants) (OR: 1.86[1.24–2.78).ConclusionPrenatal exposure to psychotropic drugs affects proxy outcomes of cognitive disabilities at school age. Exposure to psycholeptics carries the largest risk. The role of psychoanaleptics is currently unclear.
The intrinsic cause of color fading in sliced cooked cured beef during chilled storage
Authors: Ma Jing , Yu Chensha , Guo Juanjuan , Wu Mengting , Xu Yunqiang , Yi Hongchao , Sun Weiqing 
Published: May 2017

AbstractThe relationship between color change and other physical and chemical characteristics of sliced cooked cured beef (SCCB) during chilled storage were investigated using principal components analysis (PCA) to determine the color fading causes. Samples were prepared and stored at 8°C for up to 35 days in a vacuum package to simulate a supermarket storage environment; related indicators were measured periodically every week. The results showed that the first PC explained 59.82% of the total variation, and the second explained 22.28%.PC1 was a concentrated reflection of color changes ofSCCBduring storage andPC2 was an environment factor causing the change of color. The change in apparent redness is mainly caused by redox reaction of the nitroso hemochromogen (NH) (eigenvectors ofa*,CandNHinPC1 were all the maximum value of 0.28);a*was correlated withNH(0.96), free sulfhydryls (0.98), carbonyl derivatives (−0.95) formed during protein oxidation, and malondialdehyde (−0.98) and dienes (−0.92) formed by lipid oxidation. Color fading was significantly correlated with oxidizing and reducing power, existing forms of nitrogen and with thepHof the meat matrix. Changes in the internal environment of the sample initially influencedL*andb*values, and subsequentlya*.
Can we improve the efficacy of modern cataract surgery by using different tip designs? A comparison of balanced and tapered tip in femtosecond laser‐assisted cataract surgery and manual phacoemulsification
Authors: Pahlitzsch Milena , Pahlitzsch Marie‐Luise , Sumarni Uly , Pahlitzsch Thomas 
Published: May 2017

AbstractImportanceDifferent tip designs in modern cataract surgery have not been studied between the reported systems.BackgroundAim of this study is to assess the efficacy of two tip designs, Intrepid® balanced tip (BT) and Kelman tapered tip (TT), in femtosecond laser assisted cataract surgery (FLACS) and the microcoaxial torsional phacoemulsification.DesignProspective randomized unmasked cohort outcome study (hospital setting).ParticipantsThreehundert‐forty‐three eyes of 343 patientes underwent cataract surgery.MethodsData of n = 196 FLACS and n = 147 manual phacoemulsification were analysed. Intrepid® balanced tip and Kelman tapered tip, Alcon, USA, were tested in FLACS (LenSx Alcon, USA) und manual phaco (Alcon Centurion System, USA). Four study cohorts were formed; FLACS BT (n = 90, 70.2 years), FLACS TT (n = 106, 68.1years), Manual BT (n = 70, 71.3 years), Manual TT (n = 77, 71.8 years). The nuclei were graded in Lens Opacities Classification System (LOCS) II,III and IV.Main Outcome MeasuresCumulative dissipated energy (CDE%s), balanced salt solution volume (BSSml), total longitudinal energy (%s) and torsional amplitude (%s).ResultsLower CDE values were seen in FLACS compared to manual phacoemulsification (CDE %s median FLACS BT 3.28, FLACS TT 4.07, Manual BT 5.57, Manual TT 6.27). There was a significant difference between CDE FLACS BT and FLACS TT (p = 0.038), and between FLACS BT and Manual TT (p = 0.001).Conclusions and RelevanceThe right choice of tip designs in advanced phacoemulsification systems is a key factor in increasing efficacy in cataract surgery. The balanced tip showed a considerable energy‐saving advantage in FLACS and manual phacoemulsification compared to the tapered tip.
Kidney transplantation from donors with rhabdomyolysis and acute renal failure
Authors: Chen Chuan‐bao , Zheng Yi‐tao , Zhou Jian , Han Ming , Wang Xiao‐ping , Yuan Xiao‐peng , Wang Chang‐xi , He Xiao‐shun 
Published: May 2017

AbstractRhabdomyolysis in deceased donors usually causes acute renal failure (ARF), which may be considered a contraindication for kidney transplantation. From January 2012 to December 2016, 30 kidneys from 15 deceased donors with severe rhabdomyolysis and ARF were accepted for transplantation at our center. The peak serum creatinine (SCr) kinase, myoglobin, and SCr of the these donors were 15 569±8597 U/L, 37 092±42 100 μg/L, and 422±167 μmol/L, respectively. Two donors received continuous renal replacement therapy due to anuria. Six kidneys exhibited a discolored appearance (from brown to glossy black) due to myoglobin casts. The kidney transplant results from the donors with rhabdomyolysis donors were compared with those of 90 renal grafts from standard criteria donors (SCD). The estimated glomerular filtration rate at 2 years was similar between kidney transplants from donors with rhabdomyolysis and SCD (70.3±14.6 mL/min/1.73 m2 vs 72.3±15.1 mL/min/1.73 m2). We conclude that excellent graft function can be achieved from kidneys donors with ARF caused by rhabdomyolysis.
Extreme and complex variation in range‐wide abundances across a threatened Neotropical bird community
Authors: Devenish Christian , Buchanan Graeme M. , Smith Graham R. , Marsden Stuart J. 
Published: May 2017

AbstractAimUnderstanding patterns and drivers of variation in abundance across full species ranges is crucial in conservation science, but our knowledge of these forms and processes is limited, especially in the tropics. This study aims to: (1) identify patterns in variation of abundance across sites; (2) examine congruence of abundance hotspots across species and spatial autocorrelation of abundance within species; and (3) assess the nature and strength of environmental correlates of abundance (topography, habitat and human pressure).LocationTwenty‐six sites across the full ranges of 14 dry forest bird species in northern Peru.MethodsStudy sites in this patchy habitat were selected within strata derived from species distribution models, while also ensuring geographic representation. Species abundance data from variable‐width transects were compared across sites and across range core versus edge; relationships between abundance and environmental variables were examined usingGAMs, and spatial autocorrelation was examined with multivariate Mantel tests.ResultsAlthough most species were recorded at most sites, local abundance varied by one or two orders of magnitude. Several species showed a humped rather than the classic skewed abundance distribution, with abundance not necessarily highest at the centre of species’ ranges. Spatial autocorrelation in species’ local abundance was evident only at distances less than 55 km. Sites of maximum abundance for individual species did not coincide—nine different sites held highest densities of at least one species. Relationships between local abundance and almost all environmental correlates were non‐linear.Main conclusionsThe extreme variation in species abundances and the complexity in their relationships with environmental variables have important implications, both for design of conservation‐motivated surveys for which we offer some recommendations, and for the need for multiple reserves to capture high local abundances of key species.
Will climate change increase hybridization risk between potential plant invaders and their congeners in Europe?
Authors: Klonner Günther , Dullinger Iwona , Wessely Johannes , Bossdorf Oliver , Carboni Marta , Dawson Wayne , Essl Franz , Gattringer Andreas , Haeuser Emily , van Kleunen Mark , Kreft Holger , Moser Dietmar , Pergl Jan , Pyšek Petr , Thuiller Wilfried , Weigelt Patrick , Winter Marten , Dullinger Stefan 
Published: May 2017

AbstractAimInterspecific hybridization can promote invasiveness of alien species. In many regions of the world, public and domestic gardens contain a huge pool of non‐native plants. Climate change may relax constraints on their naturalization and hence facilitate hybridization with related species in the resident flora. Here, we evaluate this possible increase in hybridization risk by predicting changes in the overlap of climatically suitable ranges between a set of garden plants and their congeners in the resident flora.LocationEurope.MethodsFrom the pool of alien garden plants, we selected those which (1) are not naturalized in Europe, but established outside their native range elsewhere in the world; (2) belong to a genus where interspecific hybridization has been previously reported; and (3) have congeners in the native and naturalized flora of Europe. For the resulting set of 34 alien ornamentals as well as for 173 of their European congeners, we fitted species distribution models and projected suitable ranges under the current climate and three future climate scenarios. Changes in range overlap between garden plants and congeners were then assessed by means of the true skill statistic.ResultsProjections suggest that under a warming climate, suitable ranges of garden plants will increase, on average, while those of their congeners will remain constant or shrink, at least under the more severe climate scenarios. The mean overlap in ranges among congeners of the two groups will decrease. Variation among genera is pronounced; however, and for some congeners, range overlap is predicted to increase significantly.Main conclusionsAveraged across all modelled species, our results do not indicate that hybrids between potential future invaders and resident species will emerge more frequently in Europe when climate warms. These average trends do not preclude, however, that hybridization risk may considerably increase in particular genera.
Spinocerebellar ataxia type 10: common haplotype and disease progression rate in Peru and Brazil
Authors: Gheno T. C. , Furtado G. V. , Saute J. A. M. , Donis K. C. , Fontanari A. M. V. , Emmel V. E. , Pedroso J. L. , Barsottini O. , Godeiro‐Junior C. , van der Linden H. , Ternes Pereira E. , Cintra V. P. , Marques W. , de Castilhos R. M. , Alonso I. , Sequeiros J. , Cornejo‐Olivas M. , Mazzetti P. , Leotti V. B. , Jardim L. B. , Saraiva‐Pereira M. L. ,   Rede Neurogenetica
Published: May 2017

Background and purposeSpinocerebellar ataxia type 10 is a neurodegenerative disorder that is due to an expanded ATTCT repeat tract in the ATXN10 gene. Our aim was to describe clinical characteristics and intragenic haplotypes of patients with spinocerebellar ataxia type 10 from Brazil and Peru.MethodsExpanded alleles were detected by repeat‐primed polymerase chain reaction. Disease progression was measured by the Scale for the Assessment and Rating of Ataxia, and the Neurological Examination Score for Spinocerebellar Ataxias when possible. Haplotypes were constructed based on polymorphic markers within and outside the gene.ResultsThirteen new families were diagnosed (three from Peru). Patients from three Brazilian families diagnosed previously were also reassessed. In total, 25 individuals (16 families) were evaluated. Mean (± SD) age at onset and disease duration were 34.8 ± 10.2 and 12 ± 8 years, respectively. Common findings were ataxia, dysarthria/dysphagia, nystagmus, pyramidal signs, ophthalmoparesis and seizures. No associations were found between clinical findings and geographical origins. Twelve patients living in remote regions were examined only once. In the remaining individuals, the Scale for the Assessment and Rating of Ataxia score, and Neurological Examination Score for Spinocerebellar Ataxias worsened by 0.444 (95% CI, −0.088 to 0.800) and 0.287 (95% CI, −0.061 to 0.635) points/year, respectively. A common haplotype, 19CGGC14, was found in 11/13 of Brazilian and in 1/3 of Peruvian families.ConclusionsThe progression rate was slower than in other spinocerebellar ataxias. A consistently recurrent intragenic haplotype was found, suggesting a common ancestry for most, if not all, patients.