bluuebunny/crossref_metadata_2025_split huggingface dataset:
P0.1 is associated with duration of ventilation and mortality in patients with COVID-19 ARDS
Authors: Haar Else ter , Renes Maurits , Zijlstra Hendrik , Recinos Salvador , Dieperink Peter , Bergh Walter van den , Droogh Joep , Vonk Judith , Pillay Janesh 
Published: September 2024

Abstract

Rationale In acute respiratory distress syndrome (ARDS), optimal timing of transition from controlled to assisted ventilation and the ventilatory parameters which define this are unknown. Premature transition may impair recovery of an injured lung through patient self-inflicted lung injury.
Objectives To investigate whether the airway occlusion pressure (P0.1) directly after transition to assisted ventilation is associated with the duration of ventilation and mortality.
Methods Invasively ventilated patients with COVID-19 ARDS were retrospectively identified. P0.1 was recorded for 24 hours after transition to assisted ventilation. The primary endpoint was the number of ventilator-free days while being alive in the 28 days following the first transition from controlled to assisted ventilation (VFDav-28). Secondary outcome was ICU mortality. Multivariable logistic regression was used to identify variables independently associated with outcome parameters. ROC curves were generated to assess predictive values.
Measurements and Main Results 78 patients with COVID-ARDS were included. Higher (more negative) P0.1 was associated with less VFDav-28 and higher ICU mortality. The predictive value of P0.1 for both VFDav-28 and mortality was good (AUC 0.75).
Conclusions This study shows that P0.1 directy after transition to assited ventilation is associated with prolonged duration of invasive ventilation and ICU mortality.
UBL7 is indispensable for spermiogenesis through protecting critical factors from excessive degradation by proteasomes
Authors: Wang Fengchao , Yuan Tianyi , Yang Jiajun , Xu Dan , Li Huiqi , Min Wanping 
Published: September 2024

Abstract

Spermiogenesis is a tightly regulated process to produce mature sperm cells. The ubiquitin-proteasome system (UPS) plays a crucial role in controlling protein half-life and is essential for spermiogenesis. Recently, proteins containing ubiquitin-like domains and ubiquitin-associated domains (UBL-UBA proteins) have emerged as novel regulators within the UPS. In this study, we demonstrate that UBL7, a testis-enriched UBL-UBA protein, is indispensable for sperm formation. Deficiency of UBL7 leads to severe malformations of both the sperm tail and head. Mechanistically, UBL7 interacts with the valosin-containing protein (VCP) complex and proteasomes, and shuttles substrates between them. Notably, UBL7 slows down the degradation rates of substrates involved in endoplasmic reticulum-associated degradation (ERAD) within cells. Through a two-step immunoprecipitation method, we identify several essential factors in spermatids that are protected by UBL7, including factors involved in the development of manchette (such as IFT88), head-tail coupling apparatus (such as SPATA20) and cytoplasmic droplets (such as HK1). In summary, our findings highlight UBL7 as a guardian that protects crucial factors from excessive degradation and thereby ensures successful spermiogenesis.
Exploring the Development of Spatial Orientation and the Cognitive Levels of Preschoolers During “Three-stage” Constructive Play
Authors: Zheng Xinyue , Wu Xiaomin , Li Wen , Cao Xuetong , Su Yongming , Chen Wen 
Published: September 2024

Abstract

Spatial orientation cognition is a crucial indicator of individual cognitive ability. The preschool period is a critical phase for nurturing children's spatial ability, and interventions are required to enhance preschoolers' level of spatial orientation cognition. This study designed a constructive play divided into three stages: orientation play, task-based play, and competitive play, which aimed to gradually enhance children's core experiences in perceived orientation, spatial language, and visual imagery. The study selected 110 children aged 5-6-year-old from a public kindergarten, randomly divided into an experimental group (N=55) and a control group (N=55). The experimental group received eight weeks of constructive play teaching, while the control group participated in regular teaching activities. The results showed that both the experimental and control groups significantly improved in seven dimensions of spatial orientation cognition, but the improvement and the extent of improvement were more significant in the experimental group. It indicates that the constructive play design of this study can effectively enhance the spatial orientation cognitive level of 5-6-year-old children, and the conventional teaching plays a role, some of which are the result of natural development. The present findings shows that preschool teachers should intervene in children's spatial orientation cognition as early as possible, pay attention to individual differences among children when nurturing their spatial abilities, and fully leverage the advantages of constructive play.
Tightly security code based two tier signature using
chameleon hash functions
Authors: YONG  , Ismail Eddie Shahril 
Published: September 2024

Abstract

The advancement of quantum algorithms threatens traditional digital signatures, prompting the exploration of post-quantum solutions such as code-based signatures with chameleon hash functions. This study investigates the security effectiveness of chameleon hash-based signatures within the hash-and-sign framework, emphasizing their superior resistance to quantum-based attacks. These signatures provide not only non-repudiation and authentication but also possess non-transferable properties, ensuring their validity is confined to a designated verifier without requiring the private key from the public key holder. Furthermore, the non-interactive nature of the proposed scheme preserves efficiency comparable to that of classical schemes, making it a compelling option for quantum-resistant digital signatures.
In this paper, we introduce an innovative Kabatianskii-Krouk-Smeets (KKS) scheme over the finite field $\mathbb{F}_{q^m}$, which represents a significant advancement in cryptographic security. A key component of this proposal is the utilization of Chameleon hash functions, which form the foundation of the KKS scheme and operate using both Hamming and rank metrics. These functions are instrumental in constructing digital signature schemes that deliver not only enhanced security but also improved performance, positioning this framework as a strong contender in post-quantum cryptography.
To validate the proposed schemes, we carry out a thorough formal analysis of their security properties, confirming their robustness against key compromise and forgery attacks. Additionally, we perform an extensive performance evaluation to illustrate the schemes' efficiency and practical usability in real-world cryptographic applications.
We introduce a two-tier signature scheme combining Chameleon hash functions with KKS schemes. This approach uses rank metrics and large finite fields, enhancing security while maintaining system efficiency through the additional protective layers provided by Chameleon hash functions.
MSC: 94A60
The process of island abandonment by humans in recent European history
Authors: Mologni Fabio 
Published: September 2024

Humans have inhabited islands since prehistoric times, often cyclically occupying and abandoning them. While these patterns are increasingly well-explored archaeologically, recent temporal changes in the island biogeography of humans are still poorly understood, with consequences for the social, economic and conservation planning of islands. Here, I asked: (1) at what rates European islands were abandoned in the last 150 years, (2) whether the process of abandonment is scale-dependent and, if so, whether small islands were abandoned more consistently than large islands and (3) whether abandonment rates and the shift from smaller to larger islands increased latitudinally? I collected data for 1850 (±20) and current human inhabitation across seven archipelagos and 234 islands across Europe. I used regression techniques (i.e. logistic and linear) to explore the process of island abandonment in recent human history. Across all islands, 29.5% have been abandoned in the last 150 years. The process of abandonment is scale-dependent and smaller islands were abandoned more consistently than larger islands. Rates of abandonment increased latitudinally and were higher in northern Europe compared to southern Europe. However, scale-dependent processes were similar across the latitudinal gradient. In conclusion, a large number of islands were abandoned in Europe in the last 150 years, more so if small in size and at higher latitudes. These results bridge with previous archaeological work and have implications across several disciplines, including the sustainability of small island economies, climate adaptation strategies and conservation planning.
Of 234 European islands, almost a third were abandoned in the last 150 years, with rates ranging from 3.33% to 56% depending on the archipelago.
Small islands were abandoned more consistently, likely due to the limited amount of resources and space available.
Northern European islands were abandoned more consistently, likely due to harsher climatic conditions.
Despite general trends, idiosyncratic differences among archipelagos exist because of varying historical, social, and political circumstances.
Future trends might differ due to shifts in viable economic activities (e.g. tourism), technological advancements, and the impact of climate change.
Mediação comunitária como mecanismo de acesso à justiça
Authors: Mantovani Willian Pollis , Spengler Fabiana Marion 
Published: September 2024

O presente estudo objetiva abordar as contribuições da mediação comunitária para o acesso à justiça. Para tanto, aborda o movimento comunitarista e seus reflexos no Judiciário; expõe as raízes da mediação comunitária no mundo e no Brasil; e discute a mediação comunitária como mecanismo de acesso à justiça adequado à resolução de controvérsias. Foi empregado o método dedutivo, que permite raciocinar a partir de premissas para alcançar uma conclusão logicamente correta e alicerçada em um ou mais argumentos, ao passo que quanto à natureza da pesquisa, foi adotada a abordagem qualitativa, que foi operacionalizada pela pesquisa de natureza bibliográfica. Foi visto que a mediação comunitária é uma prática que viabiliza a emancipação tendo em vista que desperta no indivíduo a capacidade que ele tem de, por si só, reconhecer seus direitos, deveres e administrá-los de maneira consciente. Ao final do estudo concluiu-se que a Justiça Comunitária oferece uma série de benefícios para as comunidades locais, dentre os quais citam-se: aproximação entre comunidade e sistema judicial; empoderamento e participação da comunidade; resolução de conflitos de forma mais célere e eficiente; custos reduzidos; fortalecimento dos laços sociais; soluções personalizadas e culturalmente sensíveis; e prevenção de conflitos futuros. A eficácia da justiça comunitária também depende da colaboração e do comprometimento de todos os envolvidos, incluindo membros da comunidade, líderes locais e autoridades judiciais. Quando implementada de forma adequada, essa abordagem pode trazer benefícios significativos para as comunidades, promovendo uma maior equidade, justiça e coesão social.
Los derechos humanos y el empoderamiento de las niñas, igualdad de género, educación y autorregulación emocional para un futuro sostenible: Una reflexión
Authors: González María Concepción Garabandal Morelos 
Published: September 2024

Los derechos humanos, el empoderamiento femenino, juntamente con la igualdad de género, la educación y la inteligencia emocional forman un entramado crucial para un futuro equitativo y sostenible. Garantizar los derechos de mujeres y niñas es un acto de justicia y una inversión en desarrollo humano y social. En el mundo moderno, sobretodo en Latinoamérica, el patriarcado persiste, reflejado en prácticas aberrantes como los feminicidios, las violaciones, el matrimonio infantil y el embarazo adolescente, etc., perpetuando la violencia de género. El empoderamiento de las mujeres y principalmente de las niñas, surge como elemento clave para romper este ciclo, promoviendo sus derechos a libertad, a la salud física y mental, a la educación y trabajo digno. La Declaración Universal de Derechos Humanos (y diversos otros documentos) representan el marco moral y legal para este empoderamiento, subrayando la igualdad y dignidad de todos los individuos. Reconocer a las mujeres y niñas como grupo vulnerable es esencial para abordar las históricas discriminaciones que enfrentan, por lo tanto, cuando se niegan o ignoran los derechos de las mujeres y niñas, se perpetúan ciclos de desigualdad que afectan negativamente a toda la sociedad.
The level of implementation of water, sanitation, and hygiene (WASH) practices among the public basic schools in Ghana
Authors: Duah Hans 
Published: September 2024

ABSTRACT

Water, sanitation and hygiene practices (WASH) have been a major challenge facing many basic schools in Ghana for many decades. The school authority have made a number of complaints to the Ghana government through the Ministry of Education in relation to the inadequate potable water, sanitation facilities and hygiene practices in basic schools which the government has remained silent on. The aim of this study was to assess the level of implementation of Water, sanitation and hygiene practices in basic schools in the Sunyani East Education Directorate. Both qualitative and quantitative data were collected using questionnaires and interviews. The results indicate that hygiene and sanitation facilities available in schools under study included urinals, toilets, handwashing materials and solid waste disposal facilities. It was revealed that wooden slap pit latrine toilet was present in all schools except Methodist school which has cemented slaps. There were absence of toilet rolls, tap facilities and hand washing soap in all schools visited. The pupils fetched water from neighbouring houses and used it. The study recommends that the Parent-Teacher Association, School Management Committee, District Education Directorate and Ghana Education Service should team up to provide these essential facilities to basic schools in Sunyani East.
Elementos de economía matemática
Authors: Lacayo Ramón 
Published: September 2024

Elementos de Economía Matemática es un libro de texto para la asignatura Economía Matemática que cursan los estudiantes de economía en el nivel de pregrado universitario.La obra incluye una descripción de los números reales y subconjuntos tales como los racionales, irracionales, trascendentes y algebraicos. Se hace énfasis en las operaciones aritméticas y el lenguaje de las matemáticas. Se abordan nociones sobre los números complejos, su descripción geométrica, propiedades y la fórmula de Euler, así como las principales funciones elementales y el cálculo diferencial e integral aplicado a estas funciones. Se incorporan conceptos conocidos de álgebra lineal tales como matrices y determinantes. Dentro de los conceptos trabajados, destacan, por ejemplo, el estudio de las series de Taylor, la expansión de Laplace para el cálculo de determinantes, y los valores y vectores propios de una matriz. El núcleo del libro lo constituyen los capítulos de optimización, las ecuaciones recurrentes y las ecuaciones diferenciales.
Astaxanthin's Impact on Colorectal Cancer: Examining Apoptosis, Antioxidant Enzymes, and Gene Expression
Authors: Hormozi Maryam , Baharvand Parastoo 
Published: September 2024

Background
Colorectal cancer stands as the prevailing form of cancer affecting the digestive tract. Antioxidants have been observed to influence the activity of antioxidant enzymes and elevate the expression of genes within the apoptosis pathway. Consequently, this dynamic interplay appears to suppress the progression of colorectal cancer.

Objectives
This study aimed to evaluate the effect of astaxanthin on the expression of effective genes in apoptosis and the activity of antioxidant enzymes in colorectal cancer HCT-116 cells.

Methods
In this experimental investigation, HCT-116 cells underwent treatment with varying concentrations of astaxanthin for a duration of 24 hours. Subsequently, the expression levels of BAX, Bcl2, and caspase 3 genes were quantified using real-time PCR, while malondialdehyde levels and antioxidant enzyme activity were analyzed utilizing calorimetric methods.

Results
The analysis of gene expression outcomes revealed that astaxanthin elicited significant effects. It augmented the expression of BAX and caspase-3 genes, thereby promoting apoptosis while concurrently downregulating the expression of the Bcl2 gene. Consequently, this led to a decrease in malondialdehyde concentration, serving as an oxidative stress index. Additionally, the antioxidant activity of superoxide dismutase, catalase, and glutathione peroxidase showed significant increases in these treated cells.

Conclusion
Astaxanthin appears to modulate the antioxidant defense system within cancer cells. This is achieved by enhancing the activity of antioxidant enzymes while concurrently inhibiting cell growth and proliferation. Furthermore, the compound triggers apoptosis in HCT-116 cell lines, further contributing to its potential as a therapeutic agent in cancer treatment.
Fish Hydrolysates as Potential Biostimulants for Growing Legumes and Cereals to Reduce Temperature Stress
Authors: Nuzhyna Nataliia , Raksha Nataliia , Halenova Tetiana , Vovk Tetiana , Savchuk Oleksiy , Maievska Tetiana , Maievskyi Kostiantyn , Tonkha Oksana , Ostapchenko Liudmyla 
Published: September 2024

Introduction
This study aimed to develop an optimal method for the production of fish hydrolysates and to test their effectiveness as plant biostimulants under low-temperature growing conditions.

Methods
To obtain fish hydrolysates, the waste of a rainbow trout was used. Hydrolysates were prepared by enzymatic hydrolysis using fish entrails as a source of enzymes. Differences in the methods of obtaining fish hydrolysates: samples І, ІІ, ІІІ, and IV were placed into a water bath at +37°C, and sample V was left at room temperature. Further nitric, phosphoric, and acetic acids were added to samples I, II, and III, respectively, while distilled water was added to samples IV and V. The effectiveness of hydrolysates on the germination and growth of corn and beans under low-temperature growing conditions (+15/8°C) was determined.

Results
Hydrolysate I showed a positive effect on the germination and growth of beans and corn. Hydrolysate V stimulated germination and plant growth; however, it caused the abnormal development of some seedlings. The same deformations were observed with hydrolysate II. Hydrolysate III inhibited mold but also germination and the growth of crops. The greatest effect for both crops was found with the use of hydrolysate IV. The optimal concentration for beans was 1% and for corn - 10%.

Conclusion
A positive result was obtained from the use of fish hydrolysate to stimulate the germination and growth of beans and corn at low growing temperatures. Therefore, the use of hydrolysates will allow for less yield loss in case of unforeseeable temperature drops after seed sowing.
Application of a Decision-making Approach Based on Factor Analysis and DEMATEL for Evaluating Challenges of Adopting Electric Vehicles
Authors: Keshavarz-Ghorabaee Mehdi 
Published: September 2024

Background
Electric vehicles (EVs) are important as they decrease air pollution, lessen reliance on fossil fuels, and significantly contribute to cutting greenhouse gas emissions. The use of EVs in promoting a sustainable life and reducing the harmful effects of climate change is very beneficial to the environment and public health.

Objective
The purpose of this research is to evaluate the potential challenges in the adoption of electric vehicles in Iran. To this end, a set of challenges is categorized, and the interrelation and significance of these challenges are examined.

Methods
To categorize the challenges of adopting EVs, exploratory factor analysis is used, and to evaluate the relationship between them and rank them based on their importance, the DEMATEL (Decision Making Trial and Evaluation Laboratory) method, which is a Multi-Criteria Decision-Making (MCDM) technique, is employed.

Results
The results of the statistical analysis show that challenges can be divided into three categories: social, economic, and technological. Furthermore, the DEMATEL method results indicate that the three most important and impactful challenges are as follows: two social challenges, “Lack of government support to promote EVs” and “Lack of public willingness and public resistance to adopting new EV technologies,” and one technological challenge, “Immature technological advancement in EVs and battery technologies.”

Conclusion
This research provides insights into evaluating the challenges of adopting electric vehicles. The findings assist decision-makers in developing electric transportation and understanding the relationships between challenges and their significance. This study serves as a foundation for policymakers and industry stakeholders to navigate through the complex landscape of electric vehicle adoption.
Interaksi manusia dan alam pada tradisi sedekah bumi di Japon Blora
Authors: Putri Erwanda Mareta , Pinasti Vicensia Indah Sri , Apriantika Sasiana Gilar 
Published: September 2024

Penelitian meengkaji perkembangan tradisi sedekah bumi sebagai bentuk relasi antara manusia dan alam di Japon , Blora, Jawa Tengah. Dengan pendekatan kualitatif melalui penelitian lapangan mewawancarai dan mengamati kegiatan dilokasi, penelitian mengidentifikaasi pergeseran makna tradisi sedekah bumi dalam kehidupan modern. Tradisi ini tidak sekedar dipahami sebagai wujud syukur dari hasil panen yang didapatkan melainkan wujud syukur kepada Tuhan atas kesehatan dan keselamatan yang diberikan. Bentuk relasi manusia dan alam pada tradisi sedekah bumi ini adalah masyarakat menggunakan hasil yang diperolehnya, kemudian diolah menjadi makanan. Tradisi ini mendapatkan dukungan penuh dari tokoh dan anggota masyarakat di Japon, Blora.