bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of preterm birth with ADHD-like cognitive impairments and additional subtle impairments in attention and arousal malleability
Authors: James S.-N. , Rommel A.-S. , Cheung C. , McLoughlin G. , Brandeis D. , Banaschewski T. , Asherson P. , Kuntsi J. 
Published: November 2017

AbstractBackgroundWhilst preterm-born individuals have an increased risk of developing attention-deficit/hyperactivity disorder (ADHD), and are reported to have ADHD-like attention and arousal impairments, direct group comparisons are scarce.MethodsWe directly compared preterm-born adolescents (n = 186) to term-born adolescents with ADHD (n = 69), and term-born controls (n = 135), aged 11–23, on cognitive-performance, event-related potential and skin conductance level (SCL) measures associated with attention and arousal. The measures are from baseline and fast-incentive conditions of a four-choice reaction time task, previously shown to discriminate between the individuals with ADHD and controls. We aimed to establish whether preterm-born adolescents show: (a) identical cognitive-neurophysiological impairments to term-born adolescents with ADHD (b) possible additional impairments, and whether (c) the observed impairments correlate with ADHD symptom scores.ResultsThe preterm group, like the term-born ADHD group, showed increased mean reaction time (MRT) and reaction time variability (RTV) in the baseline condition, and attenuated contingent negative variation (CNV) amplitude (response preparation) in the fast-incentive condition. The preterm group, only, did not show significant within-group adjustments in P3 amplitude (attention allocation) and SCL (peripheral arousal). Dimensional analyses showed that ADHD symptoms scores correlated significantly with MRT, RTV and CNV amplitude only.ConclusionsWe find impairments in cognition and brain function in preterm-born adolescents that are linked to increased ADHD symptoms, as well as further impairments, in lack of malleability in neurophysiological processes. Our findings indicate that such impairments extend at least to adolescence. Future studies should extend these investigations into adulthood.
Stepped care in primary care – guided self-help and face-to-face cognitive behavioural therapy for common mental disorders: a randomized controlled trial
Authors: Salomonsson Sigrid , Santoft Fredrik , Lindsäter Elin , Ejeby Kersti , Ljótsson Brjánn , Öst Lars-Göran , Ingvar Martin , Lekander Mats , Hedman-Lagerlöf Erik 
Published: November 2017

AbstractBackgroundCommon mental disorders (CMD) cause large suffering and high societal costs. Cognitive behavioural therapy (CBT) can effectively treat CMD, but access to treatment is insufficient. Guided self-help (GSH) CBT, has shown effects comparable with face-to-face CBT. However, not all patients respond to GSH, and stepping up non-responders to face-to-face CBT, could yield larger response rates. The aim was to test a stepped care model for CMD in primary care by first evaluating the effects of GSH-CBT and secondly, for non-responders, evaluating the additional effect of face-to-face CBT.MethodsConsecutive patients (N = 396) with a principal disorder of depression, anxiety, insomnia, adjustment or exhaustion disorder were included. In Step I, all patients received GSH-CBT. In Step II, non-responders were randomized to face-to-face CBT or continued GSH. The primary outcome was remission status, defined as a score below a pre-established cutoff on a validated disorder-specific scale.ResultsAfter GSH-CBT in Step I, 40% of patients were in remission. After Step II, 39% of patients following face-to-face CBT were in remission compared with 19% of patients after continued GSH (p = 0.004). Using this stepped care model required less than six therapy sessions per patient and led to an overall remission rate of 63%.ConclusionsStepped care can be effective and resource-efficient to treat CMD in primary care, leading to high remission rates with limited therapist resources. Face-to-face CBT speeded up recovery compared with continued GSH. At follow-ups after 6 and 12 months, remission rates were similar in the two groups.
Constructing contempt
Authors: Spring Victoria L. , Cameron C. Daryl , Gray Kurt , Lindquist Kristen A. 
Published: November 2017

AbstractGervais & Fessler argue that contempt is a natural kind and that its experience cannot be explained by a constructionist account of emotion. We dispute these claims and offer a positive constructionist model of contempt that accounts for the existing evidence and unifies conflicting findings in the literature on contempt.
Warmth and competence as distinct dimensions of value in social emotions
Authors: Cikara Mina 
Published: November 2017

AbstractGervais & Fessler's analysis collapses across two orthogonal dimensions of social value to explain contempt: relational value, predicted by cooperation, and agentic value, predicted by status. These dimensions interact to potentiate specific social emotions and behaviors in intergroup contexts. By neglecting the unique roles of these dimensions – and their associated attributes: warmth and competence – the sentiment framework cedes predictive precision.
Deep mechanisms of social affect – Plastic parental brain mechanisms for sensitivity versus contempt
Authors: Swain James E. , Ho S. Shaun 
Published: November 2017

AbstractInsensitive parental thoughts and affect, similar to contempt, may be mapped onto a network of basic emotions moderated by attitudinal representations of social-relational value. Brain mechanisms that reflect emotional valence of baby signals among parents vary according to individual differences and show plasticity over time. Furthermore, mental health problems and treatments for parents may affect these brain systems toward or away from contempt, respectively.
Self-focusing of asymmetric cosh-Gaussian laser beams propagating through collisionless magnetized plasma
Authors: Vhanmore B. D. , Patil S. D. , Valkunde A. T. , Urunkar T. U. , Gavade K. M. , Takale M. V. 
Published: November 2017

AbstractIn this paper, self-focusing of asymmetric cosh-Gaussian laser beams in collisionless magnetized plasma has been studied. The non-linearity in dielectric constant considered herein is mainly due to the ponderomotive force. The non-linear coupled differential equations for the beam width parameters in transverse dimensions of the beam have been obtained by using WKB and paraxial approximations under parabolic equation approach. The numerical computation is completed by using fourth-order Runge–Kutta method. The effect of unlike decentered parameters in both transverse dimensions of the beam on self-focusing of cosh-Gaussian beams has been presented. Further, the effect of the static magnetic field and polarization modes of the laser has been explored.
Strong electromagnetic pulses generated in high-intensity short-pulse laser interactions with thin foil targets
Authors: Rączka P. , Dubois J.-L. , Hulin S. , Tikhonchuk V. , Rosiński M. , Zaraś-Szydłowska A. , Badziak J. 
Published: November 2017

AbstractMeasurements are reported of the target neutralization current, the target charge, and the tangential component of the magnetic field generated as a result of laser–target interaction by pulses with the energy in the range of 45–92 mJ on target and the pulse duration from 39 to 1000 fs. The experiment was performed at the Eclipse facility in CELIA, Bordeaux. The aim of the experiment was to extend investigations performed for the thick (mm scale) targets to the case of thin (μm thickness) targets in a way that would allow for a straightforward comparison of the results. We found that thin foil targets tend to generate 20–50% higher neutralization current and the target charge than the thick targets. The measurement of the tangential component of the magnetic field had shown that the initial spike is dominated by the 1 ns pulse consistent with the 1 ns pulse of the neutralization current, but there are some differences between targets of different types on sub-ns scale, which is an effect going beyond a simple picture of the target acting as an antenna. The sub-ns structure appears to be reproducible to surprising degree. We found that there is in general a linear correlation between the maximum value of the magnetic field and the maximum neutralization current, which supports the target-antenna picture, except for pulses 100s of fs long.
ROLE OF THE EMOTIONS AND CLASSROOM ENVIRONMENT IN WILLINGNESS TO COMMUNICATE
Authors: Khajavy Gholam Hassan , MacIntyre Peter D. , Barabadi Elyas 
Published: November 2017

AbstractThe purpose of the present study was to examine the relations between emotions, classroom environment, and willingness to communicate (WTC) using the advanced quantitative methodological procedure of doubly latent multilevel analysis. To this end, 1528 secondary school students from 65 different classrooms in Iran participated in the study. Results of the doubly latent multilevel analysis showed that a positive classroom environment is related to fostering WTC and enjoyment, while it reduces anxiety among students. Moreover, enjoyment was found as an important factor in increasing WTC at both student and classroom level, while anxiety reduced WTC only at the student level. Finally, the results of the study are discussed and pedagogical implications are provided for language teachers.
Discounting and intragenerational equity
Authors: Emmerling Johannes 
Published: November 2017

AbstractWe study the social discount rate, taking into account inequality within generations, that is, across countries or individuals. We show that if inequality decreases over time, the social discount rate should be lower than the one obtained by the standard Ramsey rule under certain but reasonable conditions. Applied to the global discount rate and due to the projected convergence across countries, this implies that the inequality adjusted discount rate should be about twice as high as the standard Ramsey rule predicts. For individual countries on the other hand, where inequality tends to increase over time, the effect goes in the other direction. For the United States for instance, this inequality effect leads to a reduction of the social discount rate by about 0.5 to 1 percentage points. We also present an analytical formula for the social discount rate allowing us to disentangle inequality, risk, and intertemporal fluctuation aversion.
Integrated risk management for defined benefit pension schemes: a practical guide
Authors: Hitchcox A. N. , Patel C. , Ramsey C. J. , Studd E. L. , Ma L. T. , Elliott M. B. , Keogh T. W. 
Published: November 2017

AbstractThe Working Party has developed some practical hints and tips for those developing integrated risk management (IRM) plans for UK defined benefit pension schemes in the context of the requirements of the Pensions Regulator. Four case studies are presented to illustrate its conclusions, which are encapsulated in the ten commandments for effective IRM. IRM is the consideration of investment, funding and covenant issues, and how these interact. Its purpose should be to aid decision making and so should have a clear outcome in mind. It should be a continuous process and should form part of everyday trustee governance – it is not simply a one-off exercise. Whilst most Trustees and advisors consider funding issues when setting their investment strategy and vice versa, fewer fully integrate covenant into their decision-making process. However, covenant underpins all risk taken in a pension scheme and so needs to form a regular part of trustee discussions and analysis by advisors.
Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I
Authors: Ling Sunbin , Shan Qiaonan , Liu Peng , Feng Tingting , Zhang Xuanyu , Xiang Penghui , Chen Kangchen , Xie Haiyang , Song Penghong , Zhou Lin , Liu Jimin , Zheng Shusen , Xu Xiao 
Published: November 2017

AbstractArsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia. ATO often causes severe health hazards such as hepatotoxicity, dermatosis, neurotoxicity, nephrotoxicity and cardiotoxicity. The production of reactive oxygen species, (ROS) play a significant role in ATO-induced hepatotoxicity. The oral hypoglycemic drug, metformin, is considered to be a potential novel agent for chemoprevention in the treatment of cancer. Moreover, metformin has also been shown to have hepatoprotective effects. In the present study, we demonstrated that metformin protected normal hepatocytes from ATO-induced apoptotic cell death in vitro and in vivo. Gene expression screening revealed that glucose metabolism might be related to the metformin-induced protective effect on ATO-treated AML12 cells. The metformin-promoted or induced glycolysis was not responsible for the protection of AML12 cells from ATO-induced apoptotic cell death. Instead, metformin increased the intracellular NADH/NAD+ ratio by inhibiting mitochondrial respiratory chain complex I, further decreasing the intracellular ROS induced by ATO. Treatment with low glucose or rotenone, a mitochondrial respiratory chain complex I inhibitor, also protected AML12 cells from ATO-induced apoptotic cell death. We show for the first time that metformin protects the hepatocyte from ATO by regulating the mitochondrial function. With its properties of chemoprevention, chemosensitization and the amelioration of liver damage, metformin has great prospects for clinical application other than type 2 diabetes mellitus (T2DM).
Epothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor
Authors: Mao Liang , Gao Wei , Chen Shurui , Song Ying , Song Changwei , Zhou Zipeng , Zhao Haosen , Zhou Kang , Wang Wei , Zhu Kunming , Liu Chang , Mei Xifan 
Published: November 2017

AbstractThe microtubule-stabilizing drug epothilone B (epoB) has shown potential value in the treatment of spinal cord injury (SCI) through diverse mechanisms. However, it remains elusive why a limited overall effect was observed. We aim to investigate the limiting factors underlying functional recovery promoted by epoB. The same SCI model treated by epoB was established as discussed previously. We used a cerebrospinal fluid (CSF) sample to assess the changes in cytokines in milieu of the SCI lesion site after epoB treatment. We then analyzed the source of cytokines, the state of microglia/macrophages/monocytes (M/Ms), and the recruitment of neutrophil in the lesion site by using the results of antibody array. Following these findings, we further evaluated the motor functional recovery caused by the reshaped microenvironment. Systemic administration of epoB significantly increased levels of several cytokines in the CSF of the rat SCI model; macrophage colony-stimulating factor (M-CSF) secreted by intact central nervous system (CNS) cells was one of the cytokines with increased levels. Along with epoB and other cytokines, M-CSF reshapes the SCI milieu by activating the microglias, killing bone marrow-derived macrophages, polarizing the M/M to M1 phenotype, and activating downstream cytokines to exacerbate the SCI injury, but it also increases the expression of neurotrophic factors. Anti-inflammatory therapy using a neutralizing antibody mix shows encouraging results. Usingin vivoexperiments, our findings indicate that epoB inhibits the SCI functional recovery in many ways by reshaping the milieu, which counteracts the therapeutic efficacy that led to the limited overall effectiveness.
RNA-sequencing-based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers
Authors: Ceulemans An , Verhulst Stefaan , Van Haele Matthias , Govaere Olivier , Ventura Juan-Jose , van Grunsven Leo A , Roskams Tania 
Published: November 2017

AbstractHepatic progenitor cells (HPCs) are small cells with a relative large oval nucleus and a scanty cytoplasm situated in the canals of Hering that express markers of (immature) hepatocytes and cholangiocytes. HPCs are present in large numbers in alcoholic steatohepatitis (ASH), one of the leading causes of chronic liver disease. To date, the mechanisms responsible for proliferation and differentiation of human HPCs are still poorly understood and the role of HPCs in ASH development is unknown. In this study, we aimed to characterise human HPCs and their interactions with other cells through comparison, on both protein and RNA level, of HPC-enriched cell populations from adult human liver tissue using different isolation methods. Fresh human liver tissue was collected from ASH explant livers and HPC-enriched cell populations were obtained via four different isolation methods: side population (SP), epithelial cell adhesion molecule (EpCAM) and trophoblast antigen 2 (TROP-2) membrane marker isolation and laser capture microdissection. Gene expression profiles of fluorescent-activated cell-sorted HPCs, whole liver extracts and laser microdissected HPC niches were determined by RNA-sequencing. Immunohistochemical evaluation of the isolated populations indicated the enrichment of HPCs in the SP, EpCAM+ and TROP-2+ cell populations. Pathway analysis of the transcription profiles of human HPCs showed an enrichment and activation of known HPC pathways like Wnt/β-catenin, TWEAK and HGF. Integration of the HPC niche profile suggests autocrine signalling by HPCs (TNFα, PDGFB and VEGFA) as well as paracrine signalling from the surrounding niche cells including MIF and IGF-1. In addition, we identified IL-17 A signalling as a potentially novel pathway in HPC biology. In conclusion, we provide the first RNA-seq-based, comparative transcriptome analysis of isolated human HPCs from ASH patients and revealed active signalling between HPCs and their surrounding niche cells in ASH livers and suggest that HPCs can actively contribute to liver inflammation.
River-bed armouring as a granular segregation phenomenon
Authors: Ferdowsi Behrooz , Ortiz Carlos P. , Houssais Morgane , Jerolmack Douglas J. 
Published: November 2017

AbstractRiver bed-load transport is a kind of dense granular flow, and such flows are known to segregate grains. While gravel-river beds typically have an “armoured” layer of coarse grains on the surface, which acts to protect finer particles underneath from erosion, the contribution of granular physics to river-bed armouring has not yet been investigated. Here we examine these connections in a laboratory river with bimodal sediment size, by tracking the motion of particles from the surface to deep inside the bed, and find that armour develops by two distinct mechanisms. Bed-load transport in the near-surface layer drives rapid, shear rate-dependent advective segregation. Creeping grains beneath the bed-load layer give rise to slow but persistent diffusion-dominated segregation. We verify these findings with a continuum phenomenological model and discrete element method simulations. Our experiments suggest that some river-bed armouring may be due to granular segregation from below—rather than fluid-driven sorting from above—while also providing new insights on the mechanics of segregation that are relevant to a wide range of granular flows.
Delivery of the gene encoding the tumor suppressor Sef into prostate tumors by therapeutic-ultrasound inhibits both tumor angiogenesis and growth
Authors: Mishel Sabrin , Shneyer Boris , Korsensky Lina , Goldshmidt-Tran Orit , Haber Tom , Machluf Marcelle , Ron Dina 
Published: November 2017

AbstractCarcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinomas, in a manner correlating with tumor aggressiveness. In vitro, hSef-b inhibited proliferation of TRAMP C2 cells and attenuated activation of ERK/MAPK and the master transcription factor NF-κB in response to FGF and IL-1/TNF, respectively. In vivo, transfection efficiency of a plasmid co-expressing hSef-b/eGFP into TRAMP C2 tumors was 14.7 ± 2.5% following a single TUS application. Repeated TUS treatments with hSef-b plasmid, significantly suppressed prostate tumor growth (60%) through inhibition of cell proliferation (60%), and reduction in blood vessel density (56%). In accordance, repeated TUS-treatments with hSef-b significantly inhibited in vivo expression of FGF2 and MMP-9. FGF2 is a known mitogen, and both FGF2/MMP-9 are proangiogenic factors. Taken together our results strongly suggest that hSef-b acts in a cell autonomous as well as non-cell autonomous manner. Moreover, the study demonstrates the efficacy of non-viral TUS-based hSef-b gene delivery approach for the treatment of prostate cancer tumors, and possibly other carcinomas where Sef is downregulated.
Fabrication of Subnanometer-Precision Nanopores in Hexagonal Boron Nitride
Authors: Gilbert S. Matt , Dunn Gabriel , Azizi Amin , Pham Thang , Shevitski Brian , Dimitrov Edgar , Liu Stanley , Aloni Shaul , Zettl Alex 
Published: November 2017

AbstractWe demonstrate the fabrication of individual nanopores in hexagonal boron nitride (h-BN) with atomically precise control of the pore shape and size. Previous methods of pore production in other 2D materials typically create pores with irregular geometry and imprecise diameters. In contrast, other studies have shown that with careful control of electron irradiation, defects in h-BN grow with pristine zig-zag edges at quantized triangular sizes, but they have failed to demonstrate production and control of isolated defects. In this work, we combine these techniques to yield a method in which we can create individual size-quantized triangular nanopores through an h-BN sheet. The pores are created using the electron beam of a conventional transmission electron microscope; which can strip away multiple layers of h-BN exposing single-layer regions, introduce single vacancies, and preferentially grow vacancies only in the single-layer region. We further demonstrate how the geometry of these pores can be altered beyond triangular by changing beam conditions. Precisely size- and geometry-tuned nanopores could find application in molecular sensing, DNA sequencing, water desalination, and molecular separation.
Frontal theta activation during motor synchronization in autism
Authors: Kawasaki Masahiro , Kitajo Keiichi , Fukao Kenjiro , Murai Toshiya , Yamaguchi Yoko , Funabiki Yasuko 
Published: November 2017

AbstractAutism is characterized by two primary characteristics: deficits in social interaction and repetitive behavioral patterns. Because interpersonal communication is extremely complicated, its underlying brain mechanisms remain unclear. Here we showed that both characteristics can be explained by a unifying underlying mechanism related to difficulties with irregularities. To address the issues, we measured electroencephalographm during a cooperative tapping task, which required participants to tap a key alternately and synchronously with constant rhythmic a PC program, a variable rhythmic PC program, or a human partner. We found that people with autism had great difficulty synchronizing tapping behavior with others, and exhibited greater than normal theta-wave (6 Hz) activity in the frontal cortex during the task, especially when their partner behaved somewhat irregularly (i.e. a variable rhythmic PC program or a human partner). Importantly, the higher theta-wave activity was related to the severity of autism, not the performance on the task. This indicates that people with autism need to use intense cognition when trying to adapt to irregular behavior and can easily become overtaxed. Difficulty adapting to irregular behavior in others is likely related to their own tendencies for repetitive and regular behaviors. Thus, while the two characteristics of autism have been comprehended separately, our unifying theory makes understanding the condition and developing therapeutic strategies more tractable.