bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoring Body Image After Cancer (ReBIC): Results of a Randomized Controlled Trial
Authors: Esplen Mary Jane , Wong Jiahui , Warner Ellen , Toner Brenda 
Published: January 2018

Purpose This study aimed to test a group psychosocial intervention focused on improving disturbances of body image (BI), sexual functioning, and quality of life in breast cancer (BC) survivors. Methods A prospective, randomized controlled trial was conducted to assess the efficacy of an 8-week group intervention in women after BC treatment. The manual-based intervention combined two powerful ingredients: expressive guided-imagery exercises integrated within a model of group-therapy principles. The intervention facilitates exploration of identity, the development of new self-schemas, and personal growth. In addition, the intervention included an educational component on the social and cultural factors affecting women’s self-esteem and BI. The control condition included standard care plus educational reading materials. One hundred ninety-four BC survivors who had expressed concerns about negative BI and/or difficulties with sexual functioning participated in the study; 131 were randomly assigned to the intervention, and 63 were assigned to the control condition. Participants were followed for 1 year. Results Women in the intervention group reported significantly less concern/distress about body appearance ( P < .01), decreased body stigma ( P < .01), and lower level of BC−related concerns ( P < .01), compared with women in the control group. BC-related quality of life was also better in the intervention group compared with the control group at the 1-year follow-up ( P < .01). There was no statistically significant group difference in sexual functioning. Conclusion Restoring Body Image After Cancer (ReBIC), a group intervention using guided imagery within a group-therapy approach, is an effective method for addressing BI-related concerns and quality of life post-BC. The manual-based intervention can be easily adapted to both cancer centers and primary care settings.
Epidemiologic Evidence That Excess Body Weight Increases Risk of Cervical Cancer by Decreased Detection of Precancer
Authors: Clarke Megan A. , Fetterman Barbara , Cheung Li C. , Wentzensen Nicolas , Gage Julia C. , Katki Hormuzd A. , Befano Brian , Demarco Maria , Schussler John , Kinney Walter K. , Raine-Bennett Tina R. , Lorey Thomas S. , Poitras Nancy E. , Castle Philip E. , Schiffman Mark 
Published: January 2018

Purpose Obesity has been inconsistently linked to increased cervical cancer incidence and mortality; however, the effect of obesity on cervical screening has not been explored. We investigated the hypothesis that increased body mass might decrease detection of cervical precancer and increase risk of cervical cancer even in women undergoing state-of-the-art screening. Methods We conducted a retrospective cohort study of 944,227 women age 30 to 64 years who underwent cytology and human papillomavirus DNA testing (ie, cotesting) at Kaiser Permanente Northern California (January 2003 to December 2015). Body mass index was categorized as normal/underweight (< 25 kg/m2), overweight (25 to < 30 kg/m2), or obese (≥ 30 kg/m2). We estimated 5-year cumulative risks of cervical precancer and cancer by category of body mass index using logistic Weibull survival models. Results We observed lower risk of cervical precancer (n = 4,489) and higher risk of cervical cancer (n = 490) with increasing body mass index. Specifically, obese women had the lowest 5-year risk of precancer (0.51%; 95% CI, 0.48% to 0.54% v 0.73%; 95% CI, 0.70% to 0.76% in normal/underweight women; P trend < .001). In contrast, obese women had the highest 5-year risk of cancer (0.083%; 95% CI, 0.072% to 0.096% v 0.056%; 95% CI, 0.048% to 0.066% in normal/underweight women; P trend < .001). Results were consistent in subgroups defined by age (30 to 49 v 50 to 64 years), human papillomavirus status (positive v negative), and histologic subtype (glandular v squamous). Approximately 20% of cervical cancers could be attributed to overweight or obesity in the women in our study who underwent routine cervical screening. Conclusion In this large, screened population, overweight and obese women had an increased risk of cervical cancer, likely because of underdiagnosis of cervical precancer. Improvements in equipment and/or technique to assure adequate sampling and visualization of women with elevated body mass might reduce cervical cancer incidence.
GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans
Authors: Tan Alvin W K , Subaran Sharmila C , Sauder Matthew A , Chai Weidong , Jahn Linda A , Fowler Dale E , Patrie James T , Aylor Kevin W , Basu Ananda , Liu Zhenqi 
Published: January 2018

Abstract

Context
Glucagon-like peptide-1 (GLP-1) and insulin increase muscle microvascular perfusion, thereby increasing tissue endothelial surface area and nutrient delivery.

Objective
To examine whether GLP-1 and insulin act additively on skeletal and cardiac microvasculature and conduit artery.

Design
Healthy adults underwent three study protocols in random order.

Setting
Clinical Research Unit at the University of Virginia.

Methods
Overnight-fasted participants received an intravenous infusion of GLP-1 (1.2 pmol/kg/min) or normal saline for 150 minutes with or without a 2-hour euglycemic insulin clamp (1 mU/kg/min) superimposed from 30 minutes onward. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity, and flow; brachial artery diameter, flow velocity, and blood flow; and pulse wave velocity (PWV) were measured.

Results
GLP-1 significantly increased skeletal and cardiac muscle MBV and microvascular blood flow (MBF) after 30 minutes; these remained elevated at 150 minutes. Insulin also increased skeletal and cardiac muscle MBV and MBF. Addition of insulin to GLP-1 did not further increase skeletal and cardiac muscle MBV and MBF. GLP-1 and insulin increased brachial artery diameter and blood flow, but this effect was not additive. Neither GLP-1, insulin, nor GLP-1 and insulin altered PWV. Combined GLP-1 and insulin infusion did not result in higher whole-body glucose disposal.

Conclusion
GLP-1 and insulin at physiological concentrations acutely increase skeletal and cardiac muscle microvascular perfusion and dilate conduit artery in healthy adults; these effects are not additive. Thus, GLP-1 and insulin may regulate skeletal and cardiac muscle endothelial surface area and nutrient delivery under physiological conditions.
Single-Cell Stimulation in Barrel Cortex Influences Psychophysical Detection Performance
Authors: Tanke Nouk , Borst J. Gerard G. , Houweling Arthur R. 
Published: January 2018

A single whisker stimulus elicits action potentials in a sparse subset of neurons in somatosensory cortex. The precise contribution of these neurons to the animal's perception of a whisker stimulus is unknown. Here we show that single-cell stimulation in rat barrel cortex of both sexes influences the psychophysical detection of a near-threshold whisker stimulus in a cell type–dependent manner, without affecting false alarm rate. Counterintuitively, stimulation of single fast-spiking putative inhibitory neurons increased detection performance. Single-cell stimulation of putative excitatory neurons failed to change detection performance, except for a small subset of deep-layer neurons that were highly sensitive to whisker stimulation and that had an unexpectedly strong impact on detection performance. These findings indicate that the perceptual impact of excitatory barrel cortical neurons relates to their firing response to whisker stimulation and that strong activity in a single highly sensitive neuron in barrel cortex can already enhance sensory detection. Our data suggest that sensory detection is based on a decoding mechanism that lends a disproportionally large weight to interneurons and to deep-layer neurons showing a strong response to sensory stimulation.SIGNIFICANCE STATEMENTRat whisker somatosensory cortex contains a variety of neuronal cell types with distinct anatomical and physiological characteristics. How each of these different cell types contribute to the animal's perception of whisker stimuli is unknown. We explored this question by using a powerful electrophysiological stimulation technique that allowed us to target and stimulate single neurons with different sensory response types in whisker cortex. In awake, behaving animals, trained to detect whisker stimulation, only costimulation of single fast-spiking inhibitory neurons or single deep-layer excitatory neurons with strong responses to whisker stimulation enhanced detection performance. Our data demonstrate that single cortical neurons can have measurable impact on the detection of sensory stimuli and suggest a decoding mechanism based on select cell types.
Cortical Connections Position Primate Area 25 as a Keystone for Interoception, Emotion, and Memory
Authors: Joyce Mary Kate P. , Barbas Helen 
Published: January 2018

The structural and functional integrity of subgenual cingulate area 25 (A25) is crucial for emotional expression and equilibrium. A25 has a key role in affective networks, and its disruption has been linked to mood disorders, but its cortical connections have yet to be systematically or fully studied. Using neural tracers in rhesus monkeys, we found that A25 was densely connected with other ventromedial and posterior orbitofrontal areas associated with emotions and homeostasis. A moderate pathway linked A25 with frontopolar area 10, an area associated with complex cognition, which may regulate emotions and dampen negative affect. Beyond the frontal lobe, A25 was connected with auditory association areas and memory-related medial temporal cortices, and with the interoceptive-related anterior insula. A25 mostly targeted the superficial cortical layers of other areas, where broadly dispersed terminations comingled with modulatory inhibitory or disinhibitory microsystems, suggesting a dominant excitatory effect. The architecture and connections suggest that A25 is the consummate feedback system in the PFC. Conversely, in the entorhinal cortex, A25 pathways terminated in the middle-deep layers amid a strong local inhibitory microenvironment, suggesting gating of hippocampal output to other cortices and memory storage. The graded cortical architecture and associated laminar patterns of connections suggest how areas, layers, and functionally distinct classes of inhibitory neurons can be recruited dynamically to meet task demands. The complement of cortical connections of A25 with areas associated with memory, emotion, and somatic homeostasis provide the circuit basis to understand its vulnerability in psychiatric and neurologic disorders.SIGNIFICANCE STATEMENTIntegrity of the prefrontal subgenual cingulate cortex is crucial for healthy emotional function. Subgenual area 25 (A25) is mostly linked with other prefrontal areas associated with emotion in a dense network positioned to recruit large fields of cortex. In healthy states, A25 is associated with internal states, autonomic function, and transient negative affect. Constant hyperactivity in A25 is a biomarker for depression in humans and may trigger extensive activation in its dominant connections with areas associated with emotions and internal balance. A pathway between A25 and frontopolar area 10 may provide a critical link to regulate emotions and dampen persistent negative affect, which may be explored for therapeutic intervention in depression.
ANALISA PERBANDINGAN LOGIC FUZZY METODE TSUKAMOTO, SUGENO, DAN MAMDANI ( STUDI KASUS : PREDIKSI JUMLAH PENDAFTAR MAHASISWA BARU FAKULTAS SAINS DAN TEKNOLOGI UIN SUNAN GUNUNG DJATI BANDUNG)
Authors: Irfan Mohamad , Ayuningtias Laras Purwati , Jumadi Jumadi 
Published: January 2018

ABSTRAK Universitas Islam Negeri (UIN) Sunan Gunung Djati Bandung salah satu institusi perguruan tinggi yang memiliki kualitas yang bagus dan memiliki potensi yang dapat menyerap mahasiswa baru berdasarkan berlimpahnya data awal yang diperoleh dari tahun ajaran 2013/2014 sampai dengan 2016/2017, dengan tahapan seleksi penerimaan yang banyak bahkan mahasiswa baru yang terserap beberapa tahun terakhir mengalami peningkatan dan penurunan.Dalam penelitian dilakukan analisa perbandingan algoritma fuzzy logic metode Tsukamoto, Sugeno dan Mamdani untuk memprediksi jumlah pendaftar untuk tahun kedepan dilihat dari jumlah mahasiswa yang lulus dan registrasi dari tahun sebelumnya dan dalam membandingkan perhitungannya menggunakan nilai rata-rata dari hasil yang diperoleh pada ketiga metode fuzzy tersebut dengan aplikasi berbasis web.Hasil dari penelitian yang telah dihitung bahwa metode fuzzy Mamdani mempunyai tingkat error yang lebih kecil sebesar 19,76% dibandingkan dengan metode Tsukamoto sebesar 39,03% dan Sugeno sebesar 86,41% pada prediksi jumlah pendaftar mahasiswa baru. ABSTRACT State Islamic University (UIN) Sunan Gunung Djati Bandung one of the university institutions that have good quality and has the potential to absorb new students based on the abundance of preliminary data obtained from the academic year 2013/2014 until 2016/2017, with the selection selection stage Which many new students even absorbed in the last few years have increased and decreased. In the research, comparative analysis of fuzzy logic algorithm of Tsukamoto, Sugeno and Mamdani method is used to predict the number of applicants for the next year seen from the number of students who graduated and registration from the previous year and in comparing the calculation uses the average value of the results obtained in the three fuzzy methods with web-based applications. The result of the research has been calculated that the fuzzy Mamdani method has a smaller error rate of 19.76% compared to the tsukamo method To equal to 39.03% and Sugeno equal to 86.41% in predicted number of new student enrollment How to Cite : Irfan, M. Ayuningtias, L.P. Jumadi, J. (2017). ANALISA PERBANDINGAN LOGIC FUZZY METODE TSUKAMOTO, SUGENO, DAN MAMDANI (STUDI KASUS : PREDIKSI JUMLAH PENDAFTAR MAHASISWA BARU FAKULTAS SAINS DAN TEKNOLOGI UIN SUNAN GUNUNG DJATI BANDUNG). Jurnal Teknik Informatika, 10(1), 9-16.doi:10.15408/jti.v10i1.6810Permalink/DOI: http://dx.doi.org/10.15408/jti.v10i1.6810
Analisa dan Perbandingan Bukti Forensik Aplikasi Media Sosial Facebook dan Twitter pada Smartphone Android
Authors: Mukti Wisnu Ari , Masruroh Siti Ummi , Khairani Dewi 
Published: January 2018

ABSTRAK Perkembangan teknologi internet dan smartphone yang semakin pesat diikuti pula oleh meningkatnya pengguna media sosial yang mengakses menggunakan smartphone khususnya Android. Salah satu permasalahan yang tak luput dari media sosial adalah tindak kejahatan dunia maya yang memanfaatkan media sosial. Karena pada dasarnya tidak ada kejahatan yang tidak meninggalkan jejak. Penelitian ini dilakukan untuk menemukan dan membandingkan bukti-bukti forensik tersebut pada aplikasi media sosial Facebook dan Twitter yang diakses pada smartphone Android. Facebook dan Twitter dipilih karena memiliki beberapa fitur yang mirip. Pada penelitian ini, metode simulasi digunakan dalam penelitian dengan menjalankan 11 skenario diantaranya adalah pengembalian file yang dihapus, pencarian bukti forensik berupa nama akun, lokasi, nomor telpon, tanggal lahir, photo profile, cover photo, posting berupa teks, posting berupa gambar, isi private message berupa teks dan isi private message berupa gambar. Hasil dari penelitian ini menunjukkan bahwa semua bukti forensik pada aplikasi media sosial Facebook berhasil ditemukan semua. Sedangkan pada aplikasi media sosial Twitter hanya berhasil ditemukan berupa nama akun, data lokasi, photo profile, cover photo, posting berupa teks dan posting berupa gambar. ABSTRACT The development of internet technology and smartphones are increasing rapidly followed by increasing social media users who access using a smartphone, especially Android. One of the problems that did not escape from social media is cyber crime acts that utilize social media. Because basically no crime does not leave a trace. This study was conducted to find and compare the forensic evidence on social media applications Facebook and Twitter are accessed on Android smartphones. Facebook and Twitter are selected for having some similar features. In this study, the simulation method used in the research by running 11 scenarios such as the return of deleted files, the search for forensic evidence in the form of account name, location, phone number, birth date, photo profile, photo cover, text posts, Private message in the form of text and private message content in the form of picture. The results of this study indicate that all forensic evidence on Facebook social media applications found all. While in the social media application Twitter only managed to be found in the form of account name, location data, photo profile, photo cover, text posts and post images. How to Cite : Mukti, W.A. Masruroh, S.U. Khairani, D. (2017). Analisa dan Perbandingan Bukti Forensik Aplikasi Media Sosial Facebook dan Twitter pada Smartphone Android. Jurnal Teknik Informatika, 10(1), 73-84. doi:10.15408/jti.v10i1.6820Permalink/DOI: http://dx.doi.org/10.15408/jti.v10i1.6820
Placental Findings and Effect of Prophylactic Hydrocortisone in Extremely Preterm Infants
Authors: Héneau Alice , Guimiot Fabien , Mohamed Damir , Rideau Batista Novais Aline , Alberti Corinne , Baud Olivier ,   for the PREMILOC Trial study group
Published: January 2018

OBJECTIVES:
To investigate the relationship between histologic findings of the placenta and response to early postnatal hydrocortisone treatment used to prevent bronchopulmonary dysplasia (BPD) in extremely preterm infants.

METHODS:
In an exploratory analysis of the Early Low-Dose Hydrocortisone to Improve Survival Without Bronchopulmonary Dysplasia in Extremely Preterm Infants (PREMILOC) trial, detailed placental analyses were performed on the basis of standardized macroscopic and histologic examinations. Placental histology, categorized into 3 groups, was correlated to neonatal outcomes and response to hydrocortisone treatment.

RESULTS:
Of 523 randomly assigned patients, 457 placentas were analyzed. In total, 125 out of 457 (27%) placentas were classified as normal, 236 out of 457 (52%) placentas were classified as inflammatory, and 96 out of 457 (21%) placentas were classified as vascular. Placental inflammation was associated with a significant, increased rate of BPD-free survival at 36 weeks’ postmenstrual age, independent of gestational age, treatment group, and sex (adjusted odds ratio: 1.72, 95% confidence interval [CI]: 1.05 to 2.82, P = .03). Regarding the response to treatment, the strongest benefit of hydrocortisone compared with placebo was found in infants born after placental vascular disease, with significantly more patients extubated at day 10 (risk difference: 0.32, 95% CI: 0.08 to 0.56, P = .004) and similar positive direction on survival without BPD (risk difference: 0.23, 95% CI: 0.00 to 0.46, P = .06). Adjusted to gestational age and treatment groups, placental inflammation was associated with significantly fewer patent ductus arteriosus ligation (adjusted hazard ratio: 0.58, 95% CI: 0.36 to 0.95, P = .03). Placental histology was not found to be associated with other adverse events related to preterm birth.

CONCLUSIONS:
With these findings, we confirm that early low-dose hydrocortisone confers benefits in extremely preterm infants overall and we suggest there is a higher treatment effect in those born after placental vascular disease.
Advocacy for Improving Nutrition in the First 1000 Days to Support Childhood Development and Adult Health
Authors: Schwarzenberg Sarah Jane , Georgieff Michael K. ,   COMMITTEE ON NUTRITION, Daniels Stephen , Corkins Mark , Golden Neville H. , Kim Jae H. , Lindsey C. Wesley , Magge Sheela N. 
Published: January 2018

This Policy Statement was reaffirmed October 2023.
Maternal prenatal nutrition and the child's nutrition in the first 2 years of life (1000 days) are crucial factors in a child’s neurodevelopment and lifelong mental health. Child and adult health risks, including obesity, hypertension, and diabetes, may be programmed by nutritional status during this period. Calories are essential for growth of both fetus and child but are not sufficient for normal brain development. Although all nutrients are necessary for brain growth, key nutrients that support neurodevelopment include protein; zinc; iron; choline; folate; iodine; vitamins A, D, B6, and B12; and long-chain polyunsaturated fatty acids. Failure to provide key nutrients during this critical period of brain development may result in lifelong deficits in brain function despite subsequent nutrient repletion. Understanding the complex interplay of micro- and macronutrients and neurodevelopment is key to moving beyond simply recommending a “good diet” to optimizing nutrient delivery for the developing child. Leaders in pediatric health and policy makers must be aware of this research given its implications for public policy at the federal and state level. Pediatricians should refer to existing services for nutrition support for pregnant and breastfeeding women, infants, and toddlers. Finally, all providers caring for children can advocate for healthy diets for mothers, infants, and young children in the first 1000 days. Prioritizing public policies that ensure the provision of adequate nutrients and healthy eating during this crucial time would ensure that all children have an early foundation for optimal neurodevelopment, a key factor in long-term health.
Doege–Potter-szindróma a mellhártya óriás malignus szoliter fibrosus tumorával
Authors: Kas József , Csekeő Attila , Fehér Csaba , Vágvölgyi Attila , Grmela Gábor , Varga Judit , Rozgonyi Zsolt , Soltész Ibolya , Fillinger János , Pápai Zsuzsanna , Lahm Erika , Vadász Pál 
Published: January 2018

Abstract: Infrequent solitary fibrous tumours of the pleura are associated with hypoglycaemia only in a few percent of the cases; this condition is called Doege–Potter syndrome, named after its first descriptors. Our 63 years old male patient has previously undergone clinical treatment for intrathoracic fluid accumulation on the left side caused by a giant tumour-like mass in the lower left lobe detected by CT scan. In the course of further investigations performed due to increasing load-induced dyspnoea, lung core biopsy verified low grade sarcoma in the tumour. Tumour board suggested surgery. The patient was transferred from the intensive care unit into the operation theater due to increasing dyspnoea and repeated hypoglycaemic periods in rapidly worsening general condition. Pneumonectomy and removal of the tumour was performed on the left side. Histology showed solitary fibrous tumour of the pleura corresponding to Doege–Potter syndrome. The patient was discharged without complications and underwent adjuvant chemotherapy due to pleural dissemination of the tumour observed intraoperatively. One year after surgery the patient underwent surgical removal of a locally recurrent tumour. In spite of repeated chemotherapy local and multiplex contralateral pulmonary progression was observed. Three-year survival was noted from the time of the first surgery. Orv Hetil. 2018; 159(41): 149–153.