bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excessive intravenous fluid therapy in head and neck cancer surgery
Authors: Haapio Eeva , Kinnunen Ilpo , Airaksinen Juhani K.E. , Irjala Heikki , Kiviniemi Tuomas 
Published: June 2016

ABSTRACTBackgroundThe purpose of this retrospective study was to present our assessment of modifiable perioperative factors for major cardiac and cerebrovascular events (MACCE).MethodsThis study included an unselected cohort of patients with head and neck cancer (n = 456) treated in Turku University Hospital between 1999 and 2008.ResultsPerioperative and postoperative univariate predictors of MACCE at 30‐day follow‐up were: total amount of fluids (during 24 hours) over 4000 mL, any red blood cell (RBC) infusion, treatment in the intensive care unit (ICU), tracheostomy, and microvascular reconstruction surgery. Median time from operation to MACCE was 3 days. Patients receiving >4000 mL of fluids had MACCE more often compared with those receiving <4000 mL (10.8% vs 2.4%; p < .001, respectively). Moreover, every RBC unit transfused or every liter of fluid administered over 4000 mL/24h increased the risk of MACCE 18% per unit/liter, respectively.ConclusionPatients with head and neck cancer receiving excessive intravenous fluid administration perioperatively and postoperatively are at high risk for cardiac complications, especially heart failure. © 2016 Wiley Periodicals, Inc. Head Neck 39: 37–41, 2017
Neoadjuvant chemotherapy and transoral surgery as a definitive treatment for oropharyngeal cancer: A feasible novel approach
Authors: Sadeghi Nader , Li Ning‐Wei , Taheri M. Reza , Easley Samantha , Siegel Robert S. 
Published: June 2016

AbstractBackgroundThe purpose of this study was to present our evaluation of the outcome of oropharyngeal cancer managed with neoadjuvant chemotherapy and transoral surgery (TOS) with neck dissection as definitive treatment.MethodsThis is a case series of 17 patients with advanced oropharyngeal cancer who were treated with neoadjuvant chemotherapy followed by TOS. The treatment details and oncologic outcome are reported. The volumetric response of the tumor to neoadjuvant chemotherapy is evaluated and validated by histopathology.ResultsSeventeen patients with TNM stages III and IV oropharyngeal cancer constitute this series for survival analysis. On a median and mean follow‐up of 31 and 40 months, respectively, 16 of the 17 patients were alive without recurrence. Disease‐specific survival (DSS) and overall survival (OS) at 3 years were 94.1%.ConclusionAdjuvant chemotherapy followed by TOS and neck dissection is a feasible and efficacious novel therapeutic approach for definitive management of moderately advanced oropharyngeal cancer, reserving radiotherapy (RT) for salvage or adverse features. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1837–1846, 2016
Improved local and regional control with radiotherapy for Merkel cell carcinoma of the head and neck
Authors: Strom Tobin , Naghavi Arash O. , Messina Jane L. , Kim Sungjune , Torres–Roca Javier F. , Russell Jeffery , Sondak Vernon K. , Padhya Tapan A. , Trotti Andy M. , Caudell Jimmy J. , Harrison Louis B. 
Published: June 2016

AbstractBackgroundWe hypothesized that radiotherapy (RT) would improve both local and regional control with Merkel cell carcinoma of the head and neck.MethodsA single‐institution institutional review board‐approved study was performed including 113 patients with nonmetastatic Merkel cell carcinoma of the head and neck. Postoperative RT was delivered to the primary tumor bed (71.7% cases) ± draining lymphatics (33.3% RT cases).ResultsPostoperative local RT was associated with improved local control (3‐year actuarial local control 89.4% vs 68.1%; p = .005; Cox hazard ratio [HR] 0.18; 95% confidence interval [CI] = 0.06–0.55; p = .002). Similarly, regional RT was associated with improved regional control (3‐year actuarial regional control 95.0% vs 66.7%; p = .008; Cox HR = 0.09; 95% CI = 0.01–0.69; p = .02). Regional RT played an important role for both clinical node‐negative patients (3‐year regional control 100% vs 44.7%; p = .03) and clinical/pathological node‐positive patients (3‐year regional control 90.9% vs 55.6%; p = .047).ConclusionLocal RT was beneficial for all patients with Merkel cell carcinoma of the head and neck, whereas regional RT was beneficial for clinical node‐negative and clinical/pathological node‐positive patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 48–55, 2017
Predictors of urban variable source area: a cross‐sectional analysis of urbanized catchments in the United States
Authors: Lim Theodore Chao 
Published: June 2016

AbstractMany studies have empirically confirmed the relationship between urbanization and changes to the hydrologic cycle and degraded aquatic habitats. While much of the literature focuses on extent and configuration of impervious area as a causal determinant of degradation, in this article, I do not attribute causes of decreased watershed storage on impervious area a priori. Rather, adapting the concept of variable source area (VSA) and its relationship to incremental storage to the particular conditions of urbanized catchments, I develop a statistically robust linear regression‐based methodology to detect evidence of VSA‐dominant response. Using the physical and meteorological characteristics of the catchments as explanatory variables, I then use logistic regression to statistically analyze significant predictors of the VSA classification. I find that the strongest predictor of VSA‐type response is the percent of undeveloped area in the catchment. Characteristics of developed areas, including total impervious area, percent‐developed open space and the type of drainage infrastructure, do not add to the explanatory power of undeveloped land in predicting VSA‐type response. Within only developed areas, I find that total impervious area and percent‐developed open space both decrease the odds of a catchment exhibiting evidence of VSA‐type response and the effect of developed open space is more similar to that of total impervious area than undeveloped land in predicting VSA response. Different types of stormwater management infrastructure, including combined sewer systems and infiltration, retention and detention infrastructure are not found to have strong statistically significant effects on probability of VSA‐type response. VSA‐type response is also found to be stronger during the growing season than the dormant season. These findings are consistent across a national cross‐section of urbanized watersheds, a higher resolution dataset of Baltimore Metropolitan Area watersheds and a subsample of watersheds confirmed not to be served by (combined sewer systems). Copyright © 2016 John Wiley & Sons, Ltd.
Ultrasound‐guided central venous catheterization using an optical see‐through head‐mounted display: A pilot study
Authors: Kaneko Naoki , Sato Makoto , Takeshima Taro , Sehara Yoshihide , Watanabe Eiju 
Published: June 2016

ABSTRACTPurposeWe examined the feasibility of using a head‐mounted display (HMD) to improve the ergonomics of sonographic‐guided interventional procedures.MethodsFive physicians with experience of more than 20 central venous catheterizations participated in this study. Each participant performed five pairs of simulated jugular vein catheterization under sonographic guidance with and without the HMD. The procedure time was determined as well as the number of head movements, needle redirections, posterior wall punctures, and guidewire malpositionings.ResultsAll participants could perform simulated sonographic‐guided catheterization using this HMD without turning their heads. There were no differences in the procedural time, the number of needle redirections, posterior wall punctures, and guidewire malpositionings.ConclusionsThe binocular optical see‐through HMD could be adopted for sonographic‐guided interventional procedures © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:487–491, 2016
Laser‐induced reversion of precipitates in an Al‐Li alloy: Study on temperature rise in pulsed laser atom probe
Authors: Khushaim Muna , Gemma Ryota , Al‐Kassab Talaat 
Published: June 2016

ABSTRACTThe influence of tuning the laser pulse energy during the analyses on the resulting microstructure in a specimen utilizing an ultra‐fast laser assisted atom probe was demonstrated by a case study of a binary Al‐Li alloy. The decomposition parameters, such as the size, number density, volume fraction, and composition ofprecipitates, were carefully monitored after each analysis. A simple model was employed to estimate the corresponding specimen temperature for each value of the laser energy. The results indicated that the corresponding temperatures for the laser pulse energy in the range of 10 to 80 pJ are located inside the miscibility gap of the binary Al‐Li phase diagram and fall into the metastable equilibrium field. In addition, the corresponding temperature for a laser pulse energy of 100 pJ was in fairly good agreement with reported range ofsolvus temperature, suggesting a result of reversion upon heating due to laser pulsing.Microsc. Res. Tech. 79:727–737, 2016. © 2016 Wiley Periodicals, Inc.
Freshwater clam extract supplementation improves wound healing by decreasing the tumor necrosis factor α level in blood
Authors: Peng Yi‐Chi , Fwu‐LinYang  , Subeq Yi‐Maun , Tien Chin‐Chieh , Lee Ru‐Ping 
Published: June 2016

AbstractBACKGROUNDThe freshwater clam (Corbicula fluminea) is a widely consumed functional food in Asia and is traditionally used to improve health and either prevent or treat inflammation‐related diseases. Numerous studies have proposed that freshwater clams act to prevent and attenuate inflammatory responses, and also serve as a possible inhibitor to systemic inflammation. However, there is limited information available about the effects of freshwater clams on wound healing.RESULTSThe present study investigated the influence of freshwater clam extract (FCE) on wound healing and inflammatory responses in a cutaneous incision model. Sixteen rats were used and divided into two groups: the FCE group and the normal saline (NS) group. The rats underwent dorsal full‐thickness skin excisional wounds (diameter 20 × 10 mm). FCE or NS was administered for oral feeding twice daily for 14 days after wounding. Blood samples were taken and analyzed, and wound areas were measured at several time points during the 2 weeks after excision. On day 14 after wounding, skin biopsies from the wound sites were sent for histological examination. Treatment with FCE (71.63 ± 9.51 pg mL−1) decreased tumor necrosis factor‐α levels compared to the NS group (109.86 ± 12.55 pg mL−1) after wounding at 3 h (P < 0.05). There were no significant differences in the levels of white blood cells, interleukin (IL)‐6, or IL‐10. The wound areas of the NS group (23.9%) were larger than those in the FCE group (8.26%) on day 14 (P < 0.05). Numerous fibroblasts and collagen fiber organization were observed in the FCE group.CONCLUSIONFCE supplementation improves the wound healing process. © 2016 Society of Chemical Industry
A prospective cohort study of the silk fibroin patch in chronic tympanic membrane perforation
Authors: Lee Jun Ho , Kim Dong‐Kyu , Park Hae Sang , Jeong Ju Yeon , Yeon Yeung Kyu , Kumar Vijay , Bae Sung Hee , Lee Jung Min , Moon Bo Mi , Park Chan Hum 
Published: June 2016

Objectives/HypothesisSilk fibroin patching has been used to repair acute tympanic membrane perforations. Here, we describe the advantages and outcomes of this technique for chronic tympanic membrane perforations.Study DesignIndividual cohort study.MethodsForty patients were enrolled; half underwent perichondrium myringoplasty, and the silk fibroin patch technique was applied in the remaining patients. We compared the closure, otorrhea, and complication rates; closure time; postoperative hearing gain; and patient satisfaction between the two groups.ResultsDemographic data (gender, site, age, duration, preoperative air‐bone gap, and perforation size and location) were not significantly different between the two groups. The closure rates and times, complication rates, and postoperative hearing gains were also similar in both groups. The mean operative time, otorrhea rate, and complication rate were also significantly better in the silk fibroin patch group. The intraoperative dizziness scores were higher in the conventional perichondrium myringoplasty group.ConclusionsSuccess rates were similar for the silk fibroin patch technique and conventional perichondrium myringoplasty; however, patching was an easier, faster procedure. Our results suggest that the silk fibroin patch technique is a suitable treatment for chronic tympanic membrane perforation.Level of Evidence2b Laryngoscope, 126:2798–2803, 2016
The effect of bolus consistency on swallowing function measured by high‐resolution manometry in healthy volunteers
Authors: Lan Yue , Xu Guang‐qing , Yu Fan , Lin Tuo , Jiang Li‐sheng , Liu Feng 
Published: June 2016

Objectives/HypothesisThis study evaluated the effects of three levels of bolus consistency (water, thick liquid, and paste) on the nature and duration of physiologic pressure while swallowing in healthy adults using high‐resolution manometry (HRM).Study DesignA case series of healthy adults.MethodsThirty‐four healthy young adults (mean age: 24.29 years) were instructed to swallow 3 mL and 10 mL of water, thick liquid, and paste material, respectively, during which the upper esophageal sphincter (UES) and pharyngeal pressures were measured by HRM. Variables that included maximum pharyngeal pressure, duration of pharyngeal pressure, pharyngeal pressure rise rate, UES residual pressure, duration of UES relaxation, and maximum preopening as well as postclosure UES pressure were analyzed across the three bolus consistencies by one‐way repeated measures analysis of variance.ResultsMaximum pharyngeal pressure, duration of pharyngeal pressure, duration of UES relaxation, maximum preopening UES pressure, and maximum postclosure UES pressure were significantly increased while swallowing water when compared with the thick liquid and paste materials. No significant differences were observed in UES residual pressure and pharyngeal pressure rise rate among the three different consistencies.ConclusionVariations in bolus consistency appear to have a significant effect on physiologic pressure and duration in healthy adults while swallowing water when compared with thicker materials. Identification of the differences across various bolus consistencies could provide further insight into the pathophysiology of both normal and pathological swallowing.Level of Evidence4. Laryngoscope, 127:173–178, 2017
The epidemiology of plunging ranula in South Auckland
Authors: Chin Seung Joon , Zeng Irene S. L. , Morton Randall P. 
Published: June 2016

Objectives/HypothesisEstimate the incidence rate and provide basic descriptive epidemiologic characteristics of plunging ranulas in a multi‐ethnic population.Study DesignCase series with chart review.MethodsThe study group comprised all Counties Manukau Health (CMH, Manukau City, Auckland, New Zealand) patients presenting to the CMH Department of Otolaryngology with a diagnosis of plunging ranula from January 2001 to December 2013, as recorded in the departmental case register. Non‐CMH domicile patients were excluded. South Auckland comprised the base population, as serviced by CMH. The 2006 New Zealand census data was used for population demographics.ResultsA total of 134 cases of plunging ranula were identified. The overall annual crude incidence rate was 2.4 per 100,000 person‐years. The gender specific incidence rate for males was 3.2 per 100,000 (95% confidence interval [CI]: 2.5. 3.9) and for females was 2.0 per 100,000 (95% CI: 1.5, 2.6). The overall age‐adjusted annual incidence rate was 2.6 per 100,000 (95% CI: 2.1, 3.0). The age‐adjusted incidence was highest among Maori (6.7 per 100,000, 95% CI 4.9, 8.4), followed by Pacific Island (4.4 per 100,000, 95% CI 3.2, 5.6), Asian (0.7 per 100,000, 95% CI 0.2, 1.2), and European population (0.6 per 100,000, 95% CI 0.3, 0.8).ConclusionWe have quantified for the first time the age‐specific and age‐adjusted incidence rates for plunging ranula by gender and ethnicity. The results show a likely underlying genetic predisposition for this condition, possibly with a superimposed environmental acquired factor relating to external, minor blunt trauma to the neck.Level of Evidence4. Laryngoscope, 126:2739–2743, 2016
Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species
Authors: Gelbard Alexander , Katsantonis Nicolas‐George , Mizuta Masanobu , Newcomb Dawn , Rotsinger Joseph , Rousseau Bernard , Daniero James J. , Edell Eric S. , Ekbom Dale C. , Kasperbauer Jan L. , Hillel Alexander T. , Yang Liying , Garrett C. Gaelyn , Netterville James L. , Wootten Christopher T. , Francis David O. , Stratton Charles , Jenkins Kevin , McGregor Tracy L. , Gaddy Jennifer A. , Blackwell Timothy S. , Drake Wonder P. 
Published: June 2016

Objectives/HypothesisIdiopathic subglottic stenosis (iSGS) is an unexplained obstruction involving the lower laryngeal and upper tracheal airway. Persistent mucosal inflammation is a hallmark of the disease. Epithelial microbiota dysbiosis is found in other chronic inflammatory mucosal diseases; however, the relationship between tracheal microbiota composition and iSGS is unknown.Given the critical role for host defense at mucosal barriers, we analyzed tissue specimens from iSGS patients for the presence of microbial pathogens.MethodsUtilizing 30 human iSGS, 20 intubation‐related tracheal stenosis (iLTS), and 20 healthy control specimens, we applied molecular, immunohistochemical, electron microscopic, immunologic, and Sanger‐sequencing techniques.ResultsWith unbiased culture‐independent nucleic acid, protein, and immunologic approaches, we demonstrate that Mycobacterium species are uniquely associated with iSGS. Phylogenetic analysis of the mycobacterial virulence factor rpoB suggests that, rather than Mycobacterium tuberculosis, a variant member of the Mycobacterium tuberculosis complex or a closely related novel mycobacterium is present in iSGS specimens.ConclusionThese studies identify a novel pathogenic role for established large airway bacteria and provide new targets for future therapeutic intervention.Level of EvidenceNA Laryngoscope, 127:179–185, 2017
Idiopathic subglottic stenosis is associated with activation of the inflammatory IL‐17A/IL‐23 axis
Authors: Gelbard Alexander , Katsantonis Nicolas‐George , Mizuta Masanobu , Newcomb Dawn , Rotsinger Joseph , Rousseau Bernard , Daniero James J. , Edell Eric S. , Ekbom Dale C. , Kasperbauer Jan L. , Hillel Alexander T. , Yang Liying , Garrett C. Gaelyn , Netterville James L. , Wootten Christopher T. , Francis David O. , Stratton Charles , Jenkins Kevin , McGregor Tracy L. , Gaddy Jennifer A. , Blackwell Timothy S. , Drake Wonder P. 
Published: June 2016

Objectives/HypothesisIdiopathic subglottic stenosis (iSGS) is a rare and devastating extrathoracic obstruction involving the lower laryngeal and upper tracheal airway. It arises without known antecedent injury or associated disease process. Persistent mucosal inflammation and a localized fibrotic response are hallmarks of the disease. Despite the initial clinical description of iSGS more than 40 year ago, there have been no substantive investigations into the pathogenesis of this enigmatic and progressive airway obstruction. In these studies, we present the initial characterization of the molecular pathogenesis underlying the fibrosing phenotype of iSGS.MethodsUtilizing 20 human iSGS and healthy control specimens, we applied histologic, immunohistochemical, molecular, and immunologic techniques.ResultsWe demonstrate significant activation of the canonical IL‐23/IL‐17A pathway in the tracheal mucosa of iSGS patients, as well as identify γδ T cells as the primary cellular source of IL‐17A.ConclusionOur results suggest that aberrant mucosal immune activation is a component in of the pathogenesis of iSGS. Most critically, our work offers new targets for future therapeutic intervention.Level of EvidenceNA Laryngoscope, 126:E356–E361, 2016
Rating scales for behavioral symptoms in Huntington's disease: Critique and recommendations
Authors: Mestre Tiago A. , van Duijn Erik , Davis Aileen M. , Bachoud‐Lévi Anne‐Catherine , Busse Monica , Anderson Karen E. , Ferreira Joaquim J. , Mahlknecht Philipp , Tumas Vitor , Sampaio Cristina , Goetz Chris G. , Cubo Esther , Stebbins Glenn T. , Martinez‐Martin Pablo ,   the Members of the MDS Committee on Rating Scales Development
Published: June 2016

AbstractBehavioral symptoms are an important feature of Huntington's disease and contribute to impairment in quality of life. The Movement Disorder Society commissioned the assessment of the clinimetric properties of rating scales in Huntington's disease to make recommendations regarding their use, following previously used standardized criteria. A systematic literature search was conducted to identify the scales used to assess behavioral symptoms in Huntington's disease. For the purpose of this review, 7 behavioral domains were deemed significant in Huntington's disease: irritability, anxiety, depression, apathy, obsessive‐compulsive behaviors, psychosis, and suicidal ideation. We included a total of 27 behavioral rating scales, 19 of which were of a single behavioral domain and the remaining 8 scales included multiple behavioral domains. Three rating scales were classified as “recommended” exclusively for screening purposes: the Irritability Scale for irritability, the Beck Depression Inventory‐II, and the Hospital Anxiety and Depression Scale for depression. There were no “recommended” scales for other purposes such as diagnosis, severity, or change in time or to treatment. The main challenges identified for assessment of behavioral symptoms in Huntington's disease are the co‐occurrence of multiple behavioral symptoms, the particular features of a behavioral symptom in Huntington's disease, and the need to address stage‐ and disease‐specific features, including cognitive impairment and lack of insight. The committee concluded that there is a need to further validate currently available behavioral rating scales in Huntington's disease to address gaps in scale validation for specific behavioral domains and purpose of use. © 2016 International Parkinson and Movement Disorder Society
Apoptosis‐inducing factor in nigral dopamine neurons: Higher levels in primates than in mice
Authors: Peneder Tamara M. , Bauer Jan , Pifl Christian 
Published: June 2016

ABSTRACTIntroductionThe nigrostriatal dopaminergic pathway is more susceptible to neurodegeneration in primates than in mice, including the neurotoxic effect of MPTP. Apoptosis‐inducing‐factor was shown to be involved in the pathogenesis of dopaminergic degeneration. We therefore compared its occurrence in nigral dopamine neurons of mice, monkeys, and humans.MethodsParaffin‐embedded brain slices, including the SNpc of C57BL/6J mice, rhesus monkeys, and humans, were immunohistochemically labeled for tyrosine hydroxylase (an enzyme of dopamine synthesis), microtubule‐associated protein 2 (a neuronal marker), and apoptosis‐inducing factor and examined by confocal laser scan microscopy.ResultsThe amount of apoptosis‐inducing factor in TH‐containing SN neurons was 15 times higher in monkeys and 50 times higher in humans than in mice in terms of apoptosis‐inducing factor immunoreactive neuronal area excluding the nucleus.ConclusionThe difference of apoptosis‐inducing factor levels between primates and mice might contribute to the higher sensitivity of primates to MPTP‐induced neurodegeneration of their nigrostriatal dopamine system. © 2016 International Parkinson and Movement Disorder Society