bluuebunny/crossref_metadata_2025_split huggingface dataset:
How a single particle simultaneously modifies the physical reality of two distant others: a quantum nonlocality and weak value study
Authors: de Lima Bernardo Bertúlio , Canabarro Askery , Azevedo Sérgio 
Published: January 2017

AbstractThe concept of wave-particle duality, which is a key element of quantum theory, has been remarkably found to manifest itself in several experimental realizations as in the famous double-slit experiment. In this specific case, a single particle seems to travel through two separated slits simultaneously. Nevertheless, it is never possible to measure it in both slits, which naturally appears as a manifestation of the collapse postulate. In this respect, one could as well ask if it is possible to “perceive” the presence of the particle at the two slits simultaneously, once its collapse could be avoided. In this article, we use the recently proposed entanglement mediation protocol to provide a positive answer to this question. It is shown that a photon which behaves like a wave, i.e., which seems to be present in two distant locations at the same time, can modify two existing physical realities in these locations. Calculations of the “weak trace” left by such photon also enforce the validity of the present argumentation.
The Impact of Gastric Atrophy on the Incidence of Diabetes
Authors: Yu Tse-Ya , Wei Jung-Nan , Kuo Chun-Heng , Liou Jyh-Ming , Lin Mao-Shin , Shih Shyang-Rong , Hua Cyue-Huei , Hsein Yenh-Chen , Hsu Ya-Wen , Chuang Lee-Ming , Lee Mei-Kuei , Hsiao Ching-Hsiang , Wu Ming-Shiang , Li Hung-Yuan 
Published: January 2017

AbstractGastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrophy on diabetes, we conduct a prospective cohort study to examine the relationship between H. pylori infection, gastric atrophy, and incident diabetes. In this study, subjects with gastric atrophy had a lower risk of incident diabetes, compared to those without gastric atrophy. The extent of gastric atrophy, measured by serum pepsinogen (PG) I/II ratio, was correlated with age, H. pylori IgG titer, HOMA2-IR, and HOMA2%B. When gastric atrophy is more extensive, presented as a lower serum PG I/II ratio, the risk of incident diabetes is lower. On the other hand, there was no significant association between H. pylori infection and the incidence of diabetes. In conclusion, the presence and the extent of gastric atrophy, but not H. pylori infection, are associated with incident diabetes. Further studies are needed to investigate the detailed mechanisms and the potential applications of the findings to guide diabetes screening and treatment strategies.
Optical multistability and Fano line-shape control via mode coupling in whispering-gallery-mode microresonator optomechanics
Authors: Zhang Suzhen , Li Jiahua , Yu Rong , Wang Wei , Wu Ying 
Published: January 2017

AbstractWe study a three-mode (i.e., a clockwise mode, a counterclockwise mode, and a mechanical mode) coherent coupling regime of the optical whispering-gallery-mode (WGM) microresonator optomechanical system by considering a pair of counterpropagating modes in a general case. The WGM microresonator is coherently driven by a strong control laser field and a relatively weak probe laser field via a tapered fiber. The system parameters utilized to explore this process correspond to experimentally demonstrated values in the WGM microresonator optomechanical systems. By properly adjusting the coupling rate of these two counterpropagating modes in the WGM microresonator, the steady-state displacement behaviors of the mechanical oscillation and the normalized power transmission and reflection spectra of the output fields are analyzed in detail. It is found that the mode coupling plays a crucial role in rich line-shape structures. Some interesting phenomena of the system, including optical multistability and sharp asymmetric Fano-shape optomechanically induced transparency (OMIT), can be generated with a large degree of control and tunability. Our obtained results in this study can be used for designing efficient all-optical switching and high-sensitivity sensor.
Densely packed aluminum-silver nanohelices as an ultra-thin perfect light absorber
Authors: Jen Yi-Jun , Huang Yu-Jie , Liu Wei-Chih , Lin Yueh Weng 
Published: January 2017

AbstractMetals have been formed into nanostructures to absorb light with high efficiency through surface plasmon resonances. An ultra-thin plasmonic structure that exhibits strong absorption over wide ranges of wavelengths and angles of incidence is sought. In this work, a nearly perfect plasmonic nanostructure is fabricated using glancing angle deposition. The difference between the morphologies of obliquely deposited aluminum and silver nanohelices is exploited to form a novel three-dimensional structure, which is an aluminum-silver nanohelix array on a pattern-free substrate. With a thickness of only 470 nm, densely distributed nanohelices support rod-to-rod localized surface plasmons for broadband and polarization-independent light extinction. The extinctance remains high over wavelengths from 400 nm to 2000 nm and angles of incidence from 0° to 70°.
MESL: Proposal for a Non-volatile Cascadable Magneto-Electric Spin Logic
Authors: Jaiswal Akhilesh , Roy Kaushik 
Published: January 2017

AbstractIn the quest for novel, scalable and energy-efficient computing technologies, many non-charge based logic devices are being explored. Recent advances in multi-ferroic materials have paved the way for electric field induced low energy and fast switching of nano-magnets using the magneto-electric (ME) effect. In this paper, we propose a voltage driven logic-device based on the ME induced switching of nano-magnets. We further demonstrate that the proposed logic-device, which exhibits decoupled read and write paths, can be used to construct a complete logic family including XNOR, NAND and NOR gates. The proposed logic family shows good scalability with a quadratic dependence of switching energy with respect to the switching voltage. Further, the proposed logic-device has better robustness against the effect of thermal noise as compared to the conventional current driven switching of nano-magnets. A device-to-circuit level coupled simulation framework, including magnetization dynamics and electron transport model, has been developed for analyzing the present proposal. Using our simulation framework, we present energy and delay results for the proposed Magneto-Electric Spin Logic (MESL) gates.
Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue
Authors: Lee Yun-Hee , Kim Sang-Nam , Kwon Hyun-Jung , Granneman James G. 
Published: January 2017

AbstractSustained β3 adrenergic receptor (ADRB3) activation simultaneously upregulates fatty acid synthesis and oxidation in mouse brown, beige, and white adipose tissues; however, the cellular basis of this dual regulation is not known. Treatment of mice with the ADRB3 agonist CL316,243 (CL) increased expression of fatty acid synthase (FASN) and medium chain acyl-CoA dehydrogenase (MCAD) protein within the same cells in classic brown and white adipose tissues. Surprisingly, in inguinal adipose tissue, CL-upregulated FASN and MCAD in distinct cell populations: high MCAD expression occurred in multilocular adipocytes that co-expressed UCP1+, whereas high FASN expression occurred in paucilocular adipocytes lacking detectable UCP1. Genetic tracing with UCP1-cre, however, indicated nearly half of adipocytes with a history of UCP1 expression expressed high levels of FASN without current expression of UCP1. Global transcriptomic analysis of FACS-isolated adipocytes confirmed the presence of distinct anabolic and catabolic phenotypes, and identified differential expression of transcriptional pathways known to regulate lipid synthesis and oxidation. Surprisingly, paternally-expressed genes of the non-classical gene imprinted network were strikingly enriched in anabolic phenotypes, suggesting possible involvement in maintaining the balance of metabolic phenotypes. The results indicate that metabolic heterogeneity is a distinct property of activated beige/brite adipocytes that might be under epigenetic control.
Surface roughness effects on aluminium-based ultraviolet plasmonic nanolasers
Authors: Chung Yi-Cheng , Cheng Pi-Ju , Chou Yu-Hsun , Chou Bo-Tsun , Hong Kuo-Bin , Shih Jheng-Hong , Lin Sheng-Di , Lu Tien-Chang , Lin Tzy-Rong 
Published: January 2017

AbstractWe systematically investigate the effects of surface roughness on the characteristics of ultraviolet zinc oxide plasmonic nanolasers fabricated on aluminium films with two different degrees of surface roughness. We demonstrate that the effective dielectric functions of aluminium interfaces with distinct roughness can be analysed from reflectivity measurements. By considering the scattering losses, including Rayleigh scattering, electron scattering, and grain boundary scattering, we adopt the modified Drude-Lorentz model to describe the scattering effect caused by surface roughness and obtain the effective dielectric functions of different Al samples. The sample with higher surface roughness induces more electron scattering and light scattering for SPP modes, leading to a higher threshold gain for the plasmonic nanolaser. By considering the pumping efficiency, our theoretical analysis shows that diminishing the detrimental optical losses caused by the roughness of the metallic interface could effectively lower (~33.1%) the pumping threshold of the plasmonic nanolasers, which is consistent with the experimental results.
Methamphetamine and Ovarian Steroid Responsive Cells in the Posteriodorsal Medial Amygdala are Required for Methamphetamine-enhanced Proceptive Behaviors
Authors: Williams Katrina M. , Mong Jessica A. 
Published: January 2017

AbstractMethamphetamine (Meth) is a psychomotor stimulant strongly associated with increases in sexual drive and impulse in both men and women. These changes in sexual motivation have a greater impact on women due to their likelihood of facing the greater burden of unplanned pregnancies, as well as increased risk for psychiatric co-morbidities such as depression. We have previously established a rodent model of Meth-induced increases in sexual motivation. Using this model, we have identified the posteriodorsal medial amygdala (MePD) via excitotoxic lesion studies as a necessary nucleus in Meth-facilitated female sexual motivation. While lesion studies give us insight into key nuclei that may be targets of Meth action, such an approach does not give insight into the identity of the specific MePD neurons or neural circuitry involved in Meth-induced increases in proceptive behaviors. Using the DAUN02 inactivation method, a recently established technique for removing behaviorally relevant cell populations, we present evidence that the ovarian steroid/Meth responsive cells in the MePD are necessary for Meth-induced facilitation of proceptive behaviors. These findings form the basis for future work that will allow for the classification of neuronal subtypes involved in the MePD’s modulation of proceptive behavior as well as a stronger understanding of the neurocircuitry of female sexual motivation.
Interactome of E. piscicida and grouper liver proteins reveals strategies of bacterial infection and host immune response
Authors: Li Hui , Zhu Qing-feng , Peng Xuan-xian , Peng Bo 
Published: January 2017

AbstractThe occurrence of infectious diseases is related to heterogeneous protein interactions between a host and a microbe. Therefore, elucidating the host-pathogen interplay is essential. We previously revealed the protein interactome between Edwardsiella piscicida and fish gill cells, and the present study identified the protein interactome between E. piscicida and E. drummondhayi liver cells. E. drummondhayi liver cells and bacterial pull-down approaches were used to identify E. piscicida outer membrane proteins that bind to liver cells and fish liver cell proteins that interact with bacterial cells, respectively. Eight bacterial proteins and 11 fish proteins were characterized. Heterogeneous protein-protein interactions between these bacterial cells and fish liver cells were investigated through far-Western blotting and co-immunoprecipitation. A network was constructed based on 42 heterogeneous protein-protein interactions between seven bacterial proteins and 10 fish proteins. A comparison of the new interactome with the previously reported interactome showed that four bacterial proteins overlapped, whereas all of the identified fish proteins were new, suggesting a difference between bacterial tricks for evading host immunity and the host strategy for combating bacterial infection. Furthermore, these bacterial proteins were found to regulate the expression of host innate immune-related proteins. These findings indicate that the interactome contributes to bacterial infection and host immunity.
Urinary iodine: comparison of a simple method for its determination in microplates with measurement by inductively-coupled plasma mass spectrometry
Authors: Haap Michael , Roth Heinz Jürgen , Huber Thomas , Dittmann Helmut , Wahl Richard 
Published: January 2017

AbstractThe aim of our study was to develop and validate an inexpensive, rapid, easy to use quantitative method to determine urinary iodine without major procurement costs for equipment. The rationale behind introducing this method is the increasing demand for urinary iodine assessments. Our study included 103 patients (76 female, 27 male), age (arithmetic mean) 52 ± 17.3 years. Urinary iodine was determined in microplates by a modification of the Sandell-Kolthoff reaction. The results were compared with inductively-coupled plasma mass spectrometry (ICP-MS) for iodine, considered as reference method. Geometric mean of urinary iodine determined by the Sandell-Kolthoff reaction method was 62.69 μg/l (95% confidence interval 53.16–73.92) whereas by the ICP-MS method it was 65.53 μg/l (95% confidence interval 54.77–78.41). Passing-Bablok regression equations for both methods gave y = 3.374 + 0.873x (y: Sandell-Kolthoff method, x: ICP-MS). Spearman´s correlation coefficient was 0.981, indicating a very high degree of agreement between the two methods. Bland-Altman plots showed no significant systematic difference between the two methods. The modified Sandell-Kolthoff method using microtiter plate technique presented here is a simple, inexpensive semi-automated method to determine urinary iodine with very little toxic waste. Comparison with the ICP-MS-technique yielded a good agreement between the two methods.
Aminosilane-Assisted Electrodeposition of Gold Nanodendrites and Their Catalytic Properties
Authors: Hau Nga Yu , Yang Peixian , Liu Chang , Wang Jian , Lee Po-Heng , Feng Shien-Ping 
Published: January 2017

AbstractA promising alternative route for the synthesis of three-dimensional Au dendrites was developed by direct electrodeposition from a solution of HAuCl4 containing 3-aminopropyltriethoxysilane (APTS). Ultraviolet-visible spectroscopy, fourier transform infrared spectroscopy and isothermal titration calorimetry were used to study the interaction of APTS in electrolyte. The effect of APTS on the formation of the hierarchical structure of Au dendrites was investigated by cyclic voltammetry, rotating disk electrode, electrochemical impedance spectroscopy and quartz crystal microbalance. The growth directions of the trunks and branches of the Au dendrites can be controlled by sweep-potential electrodeposition to obtain more regular structures. The efficacy of as-synthesised Au dendrites was demonstrated in the enhanced electro-catalytic activity to methanol electro-oxidation and the high sensitivity of glucose detection, which have potential applications in direct-methanol fuel cells and non-enzymatic electrochemical glucose biosensors, respectively.
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET
Authors: Perdios Louis , Lowe Alan R. , Saladino Giorgio , Bunney Tom D. , Thiyagarajan Nethaji , Alexandrov Yuriy , Dunsby Christopher , French Paul M. W. , Chin Jason W. , Gervasio Francesco Luigi , Tate Edward W. , Katan Matilda 
Published: January 2017

AbstractProtein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between static structure and function requires a more detailed understanding of their dynamic properties. For example, kinase activation may occur via a switch-like mechanism or by shifting a dynamic equilibrium between inactive and active states. Here, we utilize a combination of FRET and molecular dynamics (MD) simulations to probe the activation mechanism of the kinase domain of Fibroblast Growth Factor Receptor (FGFR). Using genetically-encoded, site-specific incorporation of unnatural amino acids in regions essential for activation, followed by specific labeling with fluorescent moieties, we generated a novel class of FRET-based reporter to monitor conformational differences corresponding to states sampled by non phosphorylated/inactive and phosphorylated/active forms of the kinase. Single molecule FRET analysis in vitro, combined with MD simulations, shows that for FGFR kinase, there are populations of inactive and active states separated by a high free energy barrier resulting in switch-like activation. Compared to recent studies, these findings support diversity in features of kinases that impact on their activation mechanisms. The properties of these FRET-based constructs will also allow further studies of kinase dynamics as well as applications in vivo.
Microvasculature remodeling in the mouse lower gut during inflammaging
Authors: Jeong Jae-Ho , Kim KwangSoo , Lim Daejin , Kim Kun-Hee , Kim Hyung-Seok , Lee Sungsu , Song Joo-Hye , Moon Byoung-Gon , Choy Hyon E. , Park Sang Chul 
Published: January 2017

AbstractInflammaging is defined as low-grade, chronic, systemic inflammation in aging, in the absence of overt infection. Age-associated deterioration of gastrointestinal function could be ascribed to the inflammaging, although evidence is yet to emerge. Here we show that microvessels in aging mouse intestine were progressively deprived of supportive structures, microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin, and became leaky. This alteration was ascribed to up-regulation of angiopoetin-2 in microvascular endothelial cells. Up-regulation of the angiopoietin-2 was by TNF-α, originated from M2-like residential CD206+ macrophages, proportion of which increases as animal ages. It was concluded that antigenic burdens encountered in intestine throughout life create the condition of chronic stage of inflammation, which accumulates M2-like macrophages expressing TNF-α. The TNF-α induces vascular leakage to facilitate recruitment of immune cells into intestine under the chronic inflammatory setting.
Identification of genetic susceptibility loci for intestinal Behçet’s disease
Authors: Kim Seung Won , Jung Yoon Suk , Ahn Jae Bum , Shin Eun-Soon , Jang Hui Won , Lee Hyun Jung , Il Kim Tae , Kim Do Young , Bang Dongsik , Kim Won Ho , Cheon Jae Hee 
Published: January 2017

AbstractSeveral recent genome-wide association studies (GWAS) identified susceptibility loci/genes for Behçet’s disease (BD). However, no study has specifically investigated the genetic susceptibility loci associated with intestinal involvement in BD. We aimed to identify distinctive genetic susceptibility loci/genes associated with intestinal involvement in BD and determine their roles in intestinal inflammation as well as their interactions with genes involved in inflammatory bowel disease (IBD). GWAS and validation studies showed intestinal BD-specific associations with an NAALADL2 gene locus (rs3914501, P = 3.8 × 10−4) and a YIPF7 gene locus (rs6838327, P = 3.5 × 10−4). Validation, haplotype, and pathway analyses showed distinct genetic architectures between intestinal BD and BD without intestinal involvement. Furthermore, network analysis revealed shared pathogenic pathways between intestinal BD and IBD. Gene functional analyses indicated that down-regulation of NAALADL2 and YIPF7 expression was associated with exacerbating intestinal inflammatory responses both in vitro and in vivo. Our results provide new insights into intestinal BD-specific genetic variations, which represents a distinct pathway from BD without intestinal involvement. Functional consequences of the intestinal BD-specific NAALADL2 and YIPF7 expression patterns proved a suggestive association with intestinal inflammation risk, which warrants further validation.
Analysis of the Global Warming Potential of Biogenic CO2 Emission in Life Cycle Assessments
Authors: Liu Weiguo , Zhang Zhonghui , Xie Xinfeng , Yu Zhen , von Gadow Klaus , Xu Junming , Zhao Shanshan , Yang Yuchun 
Published: January 2017

AbstractBiomass is generally believed to be carbon neutral. However, recent studies have challenged the carbon neutrality hypothesis by introducing metric indicators to assess the global warming potential of biogenic CO2 (GWPbio). In this study we calculated the GWPbio factors using a forest growth model and radiative forcing effects with a time horizon of 100 years and applied the factors to five life cycle assessment (LCA) case studies of bioproducts. The forest carbon change was also accounted for in the LCA studies. GWPbio factors ranged from 0.13–0.32, indicating that biomass could be an attractive energy resource when compared with fossil fuels. As expected, short rotation and fast-growing biomass plantations produced low GWPbio. Long-lived wood products also allowed more regrowth of biomass to be accounted as absorption of the CO2 emission from biomass combustion. The LCA case studies showed that the total life cycle GHG emissions were closely related to GWPbio and energy conversion efficiency. By considering the GWPbio factors and the forest carbon change, the production of ethanol and bio-power appeared to have higher GHG emissions than petroleum-derived diesel at the highest GWPbio.
Expression of acetylcholinesterase 1 is associated with brood rearing status in the honey bee, Apis mellifera
Authors: Kim Young Ho , Kim Ju Hyeon , Kim Kyungmun , Lee Si Hyeock 
Published: January 2017

AbstractAcetylcholinesterase 1 (AmAChE1) of the honey bee, Apis mellifera, has been suggested to have non-neuronal functions. A systematic expression profiling of AmAChE1 over a year-long cycle on a monthly basis revealed that AmAChE1 was predominantly expressed in both head and abdomen during the winter months and was moderately expressed during the rainy summer months. Interestingly, AmAChE1 expression was inhibited when bees were stimulated for brood rearing by placing overwintering beehives in strawberry greenhouses with a pollen diet, whereas it resumed when the beehives were moved back to the cold field, thereby suppressing brood rearing. In early spring, pollen diet supplementation accelerated the induction of brood-rearing activity and the inhibition of AmAChE1 expression. When active beehives were placed in a screen tent in late spring, thereby artificially suppressing brood-rearing activity, AmAChE1 was highly expressed. In contrast, AmAChE1 expression was inhibited when beehives were allowed to restore brood rearing by removing the screen, supporting the hypothesis that brood rearing status is a main factor in the regulation of AmAChE1 expression. Since brood rearing status is influenced by various stress factors, including temperature and diet shortage, our finding discreetly suggests that AmAChE1 is likely involved in the stress response or stress management.