bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physician Satisfaction With Clinical Laboratory Services: A College of American Pathologists Q-Probes Study of 81 Institutions
Authors: McCall Shannon J. , Souers Rhona J. , Blond Barbara , Massie Larry 
Published: September 2016

Context.—Assessment of customer satisfaction is a vital component of the laboratory quality improvement program.Objective.—To survey the level of physician satisfaction with hospital clinical laboratory services.Design.—Participating institutions provided demographic information and survey results of physician satisfaction, with specific features of clinical laboratory services individually rated on a scale of 5 (excellent) to 1 (poor).Results.—Eighty-one institutions submitted 2425 surveys. The median overall satisfaction score was 4.2 (10th percentile, 3.6; 90th percentile, 4.6). Of the 16 surveyed areas receiving the highest percentage of excellent/good ratings (combined scores of 4 and 5), quality of results was highest along with test menu adequacy, staff courtesy, and overall satisfaction. Of the 4 categories receiving the lowest percentage values of excellent/good ratings, 3 were related to turnaround time for inpatient “STAT” (tests performed immediately), outpatient STAT, and esoteric tests. The fourth was a new category presented in this survey: ease of electronic order entry. Here, 11.4% (241 of 2121) of physicians assigned below-average (2) or poor (1) scores. The 5 categories deemed most important to physicians included quality of results, turnaround times for inpatient STAT, routine, and outpatient STAT tests, and clinical report format. Overall satisfaction as measured by physician willingness to recommend their laboratory to another physician remains high at 94.5% (2160 of 2286 respondents).Conclusions.—There is a continued trend of high physician satisfaction and loyalty with clinical laboratory services. Physician dissatisfaction with ease of electronic order entry represents a new challenge. Test turnaround times are persistent areas of dissatisfaction, representing areas for improvement.
Novel integration method for III–V semiconductor devices on silicon platform
Authors: Matsumoto Keiichi , Kishikawa Junya , Nishiyama Tetsuo , Onuki Yuya , Shimomura Kazuhiko 
Published: September 2016

Abstract
A novel integration method for III–V semiconductor devices on a Si platform was demonstrated. Thin-film InP was directly bonded on a Si substrate and metal organic vapor phase epitaxy (MOVPE) growth was performed by using an InP/Si template. A void-free 2-in. InP layer bonded on a Si substrate was realized, and a low interfacial resistance and ohmic contact through the bonded interface were observed. After the MOVPE process, the as-grown structure was optically active and we observed photoluminescence (PL) intensity comparable to that from the same structure grown on InP as a reference. Furthermore, almost no lattice strain was observed from the InP layer. Then, the epitaxial growth of a GaInAsP–InP double-hetero (DH) laser diode (LD) was demonstrated on the substrate and we observed lasing emission at RT in a pulse regime. These results are promising for the integration of InP-based devices on a Si platform for optical interconnection.
Resource Use and Care Quality Differences Among Medicare Beneficiaries Undergoing Chemotherapy
Authors: Kalidindi Yamini , Jung Jeah , Feldman Roger , Carlin Caroline , Song Ge , Mitchell Aaron 
Published: September 2024

ImportanceMedicare Advantage (MA) has grown significantly over the last decade; however, MA’s performance for patients with serious conditions, such as cancer, remains unclear.ObjectiveTo compare resource use and care quality between MA and traditional Medicare (TM) beneficiaries undergoing cancer chemotherapy.Design, Setting, and ParticipantsThis cohort study used TM claims and MA encounter records from January 2015 to December 2019. Participants were MA and TM beneficiaries who initiated cancer chemotherapy between January 2016 and July 2019. Inverse probability of treatment weighting balanced characteristics between MA and TM beneficiaries, and regression estimation was used. The analysis was conducted between August 2023 and May 2024.ExposureChemotherapy initiation after a 1-year washout period.Main Outcomes and MeasuresResource use and care quality were measured during a 6-month period following chemotherapy initiation. Resource use was measured using standardized prices for services in both MA and TM, covering hospital inpatient services, outpatient care, Part D drugs, and hospice services. Chemotherapy utilization was examined for Part B chemotherapy, Part B supportive drugs, and Part D chemotherapy. Quality measures included chemotherapy-related emergency department (ED) visits and hospitalizations, avoidable ED visits, preventable hospitalizations during the 6-month episode, and survival days up to 18 months from chemotherapy initiation.ResultsThe study comprised 122 966 MA enrollees contributing to 125 518 episodes (mean [SD] age, 73.2 [7.6] years; 68 479 [54.6%] female; 8900 [7.1%] Hispanic, 18 423 [14.7%] non-Hispanic Black, and 94 817 [75.5%] non-Hispanic White participants) and 274 666 TM beneficiaries, contributing 282 200 episodes (mean [SD] age, 73.1 [8.4] years; 155 709 [55.2%] female; 10 666 [3.8%] Hispanic, 22 088 [7.8%] non-Hispanic Black, and 241 113 [85.4%] non-Hispanic White participants). Adjusted total resource use per enrollee during the 6-month episode was $8498 (95% CI, $8178 to $8817) lower in MA than TM ($61 004 vs $69 502). Part B chemotherapy resource use accounted for most of the difference in total resource use, with MA enrollees having $4765 (95% CI, $4547 to $4982) lower use than TM beneficiaries. Lower resource use for Part B chemotherapy in MA was associated with 1.03 fewer chemotherapy visits (95% CI, 0.99 to 1.06 visits) and $277 (95% CI, $183 to $272) less expensive chemotherapy per visit. Findings on quality were mixed, but importantly, survival did not differ between MA and TM patients who initiated chemotherapy.Conclusions and RelevanceIn this cohort study of Medicare beneficiaries with cancer undergoing chemotherapy, MA enrollment was associated with lower resource use but not shorter survival.
Enhancing Electric Vehicle Charging Systems With a Versatile Bidirectional Buck Boost DC to DC Converter Integrated With Solar Photovoltaic Technology
Authors: Arun Kumar D. , Ramkumar A. , Rajendran S. 
Published: September 2024

ABSTRACTRenewable energy‐based electric vehicle (EV) charging systems have become increasingly popular in recent years, particularly in commercial and industrial environments. This study looks at a broad‐spectrum bidirectional buck boost DC to DC converter employing solar photovoltaic (PV) technology. This combination is intended for usage in vehicle to grid (V2G) and grid to vehicle (G2V) modes for electric car applications. In both operating modes, the converter attains a high‐voltage transfer gain ratio (VTGR) without any theoretical output voltage restrictions. It provides evidence on suitable nature for EV applications with versatility, redundancy, and practicality. The theoretical evaluation was verified by the development and testing of a 500 W experimental model. A peak efficiency of 97.8% and 97.4% in V2G and G2V modes is indicated by the data, confirming the usefulness and efficacy of this integrated strategy. These results show that the bidirectional buck boost DC to DC converter, when combined with the suggested integration of PV and EV, improves V2G‐G2V operations in EV charging systems and is both practicable and feasible.
Sunlight‐Activated Room‐Temperature Phosphorescent Carbon Dots
Authors: Guo Zengsheng , Wang Chenchen , Qi Fangzheng , Dong Juan , Xue Jingtian , Zhang Yuhan , Xu Bo , Liu Guang‐Ning , Sun Yiqiang , Li Cuncheng 
Published: September 2024

AbstractThe efficient utilization of clean and safe sunlight as an excitation source for room‐temperature phosphorescent (RTP) materials is crucial for practical applications in solar energy. Herein, sunlight‐activated RTP nitrogen‐doped carbon dots @ alumina (N‐CDs@Al2O3) composites with long lifetime and exceptional stability are designed and fabricated using an in situ preparation strategy. The N‐CDs@Al2O3 display bright yellow RTP (more than 18 s to the naked eye) when activated by sunlight. The results indicate that the introduction of nitrogen into the CDs not only promotes the effective filling of triplet excitons but also facilitates the red‐shift of the absorption spectrum of the CDs. The high rigidity structure of Al2O3 and stable strong covalent bonds effectively protect the triplet excitons. Additionally, the numerous oxygen vacancy defects formed under appropriate calcination conditions effectively store and release triplet excitons. Finally, the application of N‐CDs@Al2O3 in multi‐color 3D artworks, defense markings, and emergency signs is demonstrated. This work provides design principles and feasible strategies for the development of new sunlight‐activated RTP materials.
Electrocatalysis under Magnetic Fields
Authors: Chen Jiang‐Bo , Ying Jie , Tian Yuan , Xiao Yu‐Xuan , Yang Xiao‐Yu 
Published: September 2024

AbstractThe introduction of external magnetic field has recently emerged as a great promising strategy for largely enhancing the efficiency of the electrocatalytic system, but it lacks a systematic understanding of the underlying mechanisms. This review is aimed at fully illuminating the recent research progress on magnetic field‐enhanced electrocatalysis via the combination of theoretical calculation and experiment results. The account begins by introducing basic systems employed for magnetic field generation, and then possible mechanisms for this magnetoelectric effect, including those associated with Lorentz and Kelvin forces, and magnetothermal, magnetohydrodynamic, spin selectivity, and Maxwell stress effects. Next, studies in which magnetic fields are utilized to enhance performances of a variety of electrocatalytic reactions are discussed in detail. Finally, a perspective of challenges and opportunities facing future research in this area is given.
Design Principles of Catalytic Materials for CO2 Hydrogenation to Methanol
Authors: Araújo Thaylan Pinheiro , Mitchell Sharon , Pérez‐Ramírez Javier 
Published: September 2024

AbstractHeterogeneous catalysts are essential for thermocatalytic CO2 hydrogenation to methanol, a key route for sustainable production of this vital platform chemical and energy carrier. The primary catalyst families studied include copper‐based, indium oxide‐based, and mixed zinc–zirconium oxides‐based materials. Despite significant progress in their design, research is often compartmentalized, lacking a holistic overview needed to surpass current performance limits. This perspective introduces generalized design principles for catalytic materials in CO2‐to‐methanol conversion, illustrating how complex architectures with improved functionality can be assembled from simple components (e.g., active phases, supports, and promoters). After reviewing basic concepts in CO2‐based methanol synthesis, engineering principles are explored, building in complexity from single to binary and ternary systems. As active nanostructures are complex and strongly depend on their reaction environment, recent progress in operando characterization techniques and machine learning approaches is examined. Finally, common design rules centered around symbiotic interfaces integrating acid–base and redox functions and their role in performance optimization are identified, pinpointing important future directions in catalyst design for CO2 hydrogenation to methanol.
Grain Boundary Filling Empowers (002)‐Textured Zn Metal Anodes with Superior Stability
Authors: Chen Zibo , Wang Yizhou , Wu Qiang , Wang Cheng , He Qian , Hu Tao , Han Xuran , Chen Jialu , Zhang Yu , Chen Jianyu , Yang Lijun , Wang Xuebin , Ma Yanwen , Zhao Jin 
Published: September 2024

AbstractAqueous Zn battery is promising for grid‐level energy storage due to its high safety and low cost, but dendrite growth and side reactions at the Zn metal anode hinder its development. Designing Zn with (002) orientation improves the stability of the Zn anode, yet grain boundaries remain susceptible to corrosion and dendrite growth. Addressing these intergranular issues is crucial for enhancing the electrochemical performance of (002)‐textured Zn. Here, a strategy based on grain boundary wetting to fill intergranular regions and mitigate these issues is reported. By systematically investigating boundary fillers and filling conditions, In metal is chosen as the filler, and one‐step annealing is used to synergistically convert commercial Zn foils into single (002)‐textured Zn while filling In into the boundaries. The inter‐crystalline‐modified (002)‐textured Zn (IM(002) Zn) effectively inhibits corrosion and dendrite growth, resulting in excellent stability in batteries. This work offers new insights into Zn anode protection and the development of high‐energy Zn batteries.
Unraveling the Complexity of Parkinson's Disease: Insights into Pathogenesis and Precision Interventions
Authors: Yan Han , Coughlin Cole , Smolin Lee , Wang Jin 
Published: September 2024

AbstractParkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss, leading to motor and non‐motor symptoms. Early detection before symptom onset is crucial but challenging. This study presents a framework integrating circuit modeling, non‐equilibrium dynamics, and optimization to understand PD pathogenesis and enable precision interventions. Neuronal firing patterns, particularly oscillatory activity, play a critical role in PD pathology. The basal ganglia network, specifically the subthalamic nucleus‐external globus pallidus (STN‐GPe) circuitry, exhibits abnormal activity associated with motor dysfunction. The framework leverages the non‐equilibrium landscape and flux theory to identify key connections generating pathological activity, providing insights into disease progression and potential intervention points. The intricate STN‐GPe interplay is highlighted, shedding light on compensatory mechanisms within this circuitry may initially counteract changes but later contribute to pathological alterations as disease progresses. The framework addresses the need for comprehensive evaluation methods to assess intervention outcomes. Cross‐correlations between state variables provide superior early warning signals compared to traditional indicators relying on critical slowing down. By elucidating compensatory mechanisms and circuit dynamics, the framework contributes to improved management, early detection, risk assessment, and potential prevention/delay of PD development. This pioneering research paves the way for precision medicine in neurodegenerative disorders.
Scalable Asymmetric Fabric Evaporator for Solar Desalination and Thermoelectricity Generation
Authors: Fu Zhuan , Zhong Dandan , Zhou Sijie , Zhang Leyan , Long Weihao , Zhang Jiajing , Wang Xinyu , Xu Jiahao , Qin Jieyao , Gong Junyao , Li Li , Xia Liangjun , Yu Bin , Xu Weilin 
Published: September 2024

AbstractThe integration of solar interfacial evaporation and power generation offers a sustainable solution to address water and electricity scarcity. Although water‐power cogeneration schemes are proposed, the existing schemes lack scalability, flexibility, convenience, and stability. These limitations severely limit their future industrial applications. In this study, we prepared a hybrid fabric composed of basalt fibers and cotton yarns with asymmetric structure using textile weaving technology. The cotton yarn in lower layer of fabric facilitates water transport, while the basalt fibers in upper layer enable thermal localization and water supply balancing. The carbon black is deposited on top layer by flame burning to facilitate photothermal conversion. The fabric exhibits a high evaporation rate of 1.52 kg m−2 h−1, which is 3.6 times that of pure water, and an efficiency of 88.06% under 1 kW m−2 light intensity. After assembly with a thermoelectric module, the hybrid system achieves a maximum output power density of 66.73 mW m−2. By exploiting the scalability of fabric, large‐scale desalination and power production can be achieved in outdoor environments. This study demonstrates the seamless integration of fabric‐based solar evaporation and waste heat‐to‐energy technologies, thereby providing new avenues for the development of scalable and stable water‐power cogeneration systems.
High Thickness Tolerance in All‐Polymer‐Based Organic Photovoltaics Enables Efficient and Stable In‐Door Operation
Authors: Zhang Lei , Lee Seonjeong , Park Song Yi , Sandberg Oskar J. , Yang Emily J. , Meredith Paul , Kim Yun‐Hi , Kim Ji‐Seon 
Published: September 2024

AbstractOrganic photovoltaics (OPVs) have great potential to drive low‐power consumption electronic devices under indoor light due to their highly tunable optoelectronic properties. Thick devices (>300 nm photo‐active junctions) are desirable to maximize photocurrent and to manufacture large‐scale modules via solution‐processing. However, thick devices usually suffer from severe charge recombination, deteriorating device performances. Herein, the study demonstrates excellent thickness tolerance of all‐polymer‐based PVs for efficient and stable indoor applications. Under indoor light, device performance is less dependent on photoactive layer thickness, exhibiting the best maximum power output in thick devices (34.7 µW cm−2 in 320–475 nm devices). Thick devices also exhibit much better photostability compared with thin devices. Such high thickness tolerance of all‐polymer‐based PV devices under indoor operation is attributed to strongly suppressed space‐charge effects, leading to reduced bimolecular recombination losses in thick devices. The unbalanced charge carrier mobilities are identified as the main cause for significant space‐charge effects, which is confirmed by drift‐diffusion simulations. This work suggests that all‐polymer‐based PVs, even with unbalanced mobilities, are highly desirable for thick, efficient, and stable devices for indoor applications.
Cold crystallization of poly (ether ether ketone) membranes
Authors: Bai Bingyang , He Rongrong , Yan Jiajun , He Tao 
Published: September 2024

AbstractThe semi‐crystalline nature of poly(ether ether ketone) (PEEK) has been a great challenge to prepare PEEK membranes with targeted morphology and crystallization via immersion precipitation. This paper reported a novel observation of cold crystallization (CC) and the key factors affecting the formation of CC in the PEEK membrane via immersion precipitation phase separation, using mixture solvents of concentrated sulfuric acid (SA) and methane sulfonic acid (MSA). The CC in PEEK was identified by an exothermal peak slightly above the PEEK's glass transition temperature (Tg) at 146–150°C in differential scanning calorimetry (DSC). The CC formation was contributed to folded rigid segments resulted from the solid–liquid phase separation. Factors affecting CC investigated in the membrane preparation were the exposure time before immersion and the solvent ratio. It was found that increased exposure time from 0 min to 15 min in ambient led to cellular pore structure with decreased total crystallinity (28.9%–25.5%), but increased proportion of CC (27.7%–43.6%) for PEEK3:1 membrane. Increase of SA in the mixture solvent resulted in decreased CC and total degree of crystallization. Tensile strength measurements demonstrated that the CC contributed positively the strain of PEEK membranes. The findings suggested a new factor of CC for better understanding, control and design of PEEK membranes.
Cyanobacteria: role in sustainable biomanufacturing and nitrogen fixation
Authors: Nawaz Taufiq , Fahad Shah , Gu Liping , Saud Shah , Zhou Ruanbao 
Published: September 2024

AbstractCyanobacteria, renowned for their nitrogen‐fixing characteristics, are important for sustainable biomanufacturing and agricultural innovation. This review explores the synergy between cyanobacteria and nitrogen fixation, highlighting their potential to revolutionize biobased compound production and reduce the ecological impact of traditional nitrogen sources. It focuses on genetic enhancements and synthetic biology techniques, which transform these microorganisms into sustainable nitrogen providers. Current applications range from agricultural enhancement to cutting‐edge biotechnology, highlighting the important consequences of cyanobacterial nitrogen fixation. Challenges persist, however, requiring a meticulous analysis of ecological, regulatory, and scalability concerns. The untapped potential of cyanobacteria in nitrogen fixation promises a significant shift in biomanufacturing and environmental stewardship. The aim of this article is to inspire high‐impact research and transformative applications in biotechnology and sustainability.
Biointerface engineering through amalgamation of gene technology and site‐specific growth factor conjugation for efficient osteodifferentiation
Authors: Wu Zhenxu , Mo Li , Wang Zongliang , Song Liangsong , Kobatake Eiry , Ito Yoshihiro , Wang Yi , Zhang Peibiao 
Published: September 2024

AbstractThe development of bone implants through bioinspired immobilization of growth factors remains a key issue in the generation of biological interfaces, especially in enhancing osteodifferentiation ability. In this study, we developed a strategy for surface functionalization of poly(lactide‐glycolide) (PLGA) and hydroxyapatite (HA) composite substrates through site‐specific conjugation of bone morphogenetic protein 2 containing 3,4‐hydroxyphenalyalanine (DOPA‐BMP2) mediated by tyrosinase and sortase A (SrtA). Firstly, the growth factor BMP2‐LPETG containing LPETG motif was successfully expressed in Escherichia coli through recombinant DNA technology. The excellent binding affinity of binding growth factor (DOPA‐BMP2) was achieved by converting the tyrosine residue (Y) of YKYKY‐GGG peptide into DOPA (X) by tyrosinase, which bound to the substrates. Then its GGG motif was specifically bound to the end of BMP2‐LPETG mediated by SrtA. Therefore, the generated bioactive DOPA‐BMP2/PLGA/HA substrates significantly promoted the osteogenic differentiation of MC3T3‐E1 cells. Thanks to this microbial‐assisted engineering approach, our work presents a facile and highly site‐specific strategy to engineer biomimetic materials for orthopedics and dentistry by effectively delivering growth factors, peptides, and other biomacromolecules.
DNA‐Encoded Noncanonical Substrate Library for Protease Profiling
Authors: Zhang Huiya , Xing Yuyu , Yang Yixuan , Tang Bixi , Zong Zhaoyun , Li Jia , Zang Yi , Bogyo Matthew , Lu Xiaojie , Chen Shiyu 
Published: September 2024

AbstractProfiling the substrate sequence preferences of proteases is important for understanding both biological functions as well as for designing protease inhibitors. Several methods are available for profiling the sequence specificity of proteases. However, there is currently no rapid and high‐throughput method to profile specificity of proteases for noncanonical substrates. In this study, we described a strategy to use a DNA‐encoded noncanonical substrate library to identify the protease substrates composed of both canonical and noncanonical amino acids. This approach uses a DNA‐encoded peptide library and introduces a biotin molecule at the N‐terminus to immobilize the library on a solid support. Upon protease hydrolysis, the released DNA tag of the substrate peptides can be sequenced to identify the substrate structures. Using this approach, we profiled trypsin and fibroblast activation protein α and discovered noncanonical substrates that were more efficiently cleaved than the commonly used substrates. The identified substrates of FAP were further used to design corresponding covalent inhibitors containing non‐canonical sequences with high potency for the target protease. Overall, our approach can aid in the development of new protease substrates and inhibitors.