bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study
Authors: Lynch Rhoda , Diggins Eileen L , Connors Susan L , Zimmerman Andrew W , Singh Kanwaljit , Liu Hua , Talalay Paul , Fahey Jed W 
Published: October 2017

Introduction Autism spectrum disorder (ASD) affects 1 in 68 children, is characterized by impaired social interaction and communication as well as restricted or repetitive behaviors, and varies widely with respect to its causes and presentations. There are no validated pharmacologic treatments for the core symptoms of ASD. The social, medical, and economic burdens of ASD on families and caregivers are profound. We recently showed in a small clinical trial that sulforaphane (SF) from broccoli sprouts could significantly reduce the behavioral symptoms of ASD. Methods After we completed the intervention phase of the original trial (2011–2013), many caregivers used over-the-counter dietary SF supplements in order to attempt to maintain improvements similar to those noted during the intervention. We periodically followed the progress of study participants through the summer of 2016. Results Families of 16 of the 26 subjects who received SF as part of the original study responded to requests for further information. Of these subjects, 6 did not continue taking SF supplements after the study. Nine of the 16 subjects are still taking an SF supplement and a 10th planned to. We present the edited testimonials of their caregivers in this case series. Conclusions Many parents and caregivers articulated the positive effects of SF, both during the intervention phase and in the ensuing 3 years reported herein. These observations may contribute to understanding ASD and to treatments that may alleviate some of its symptoms. Diet- and supplement-based therapies deserve careful consideration for their potential to provide vital clinical as well as biochemical information about ASD.
Long-Term Follow-Up of Cardiac Function and Quality of Life for Patients in NSABP Protocol B-31/NRG Oncology: A Randomized Trial Comparing the Safety and Efficacy of Doxorubicin and Cyclophosphamide (AC) Followed by Paclitaxel With AC Followed by Paclitaxel and Trastuzumab in Patients With Node-Positive Breast Cancer With Tumors Overexpressing Human Epidermal Growth Factor Receptor 2
Authors: Ganz Patricia A. , Romond Edward H. , Cecchini Reena S. , Rastogi Priya , Geyer Charles E. , Swain Sandra M. , Jeong Jong-Hyeon , Fehrenbacher Louis , Gross Howard M. , Brufsky Adam M. , Flynn Patrick J. , Wahl Tanya A. , Seay Thomas E. , Wade James L. , Biggs David D. , Atkins James N. , Polikoff Jonathan , Zapas John L. , Mamounas Eleftherios P. , Wolmark Norman 
Published: October 2017

Purpose Early cardiac toxicity is a risk associated with adjuvant chemotherapy plus trastuzumab. However, objective measures of cardiac function and health-related quality of life are lacking in long-term follow-up of patients who remain cancer free after completion of adjuvant treatment. Patients and Methods Patients in NSABP Protocol B-31 received anthracycline and taxane chemotherapy with or without trastuzumab for adjuvant treatment of node-positive, human epidermal growth factor receptor 2–positive early-stage breast cancer. A long-term follow-up assessment was undertaken for patients who were alive and disease free, which included measurement of left ventricular ejection fraction by multigated acquisition scan along with patient-reported outcomes using the Duke Activity Status Index (DASI), the Medical Outcomes Study questionnaire, and a review of current medications and comorbid conditions. Results At a median follow-up of 8.8 years among eligible participants, five (4.5%) of 110 in the control group and 10 (3.4%) of 297 in the trastuzumab group had a > 10% decline in left ventricular ejection fraction from baseline to a value < 50%. Lower DASI scores correlated with age and use of medications for hypertension, cardiac conditions, diabetes, and hyperlipidemia, but not with whether patients had received trastuzumab. Conclusion In patients without underlying cardiac disease at baseline, the addition of trastuzumab to adjuvant anthracycline and taxane-based chemotherapy does not result in long-term worsening of cardiac function, cardiac symptoms, or health-related quality of life. The DASI questionnaire may provide a simple and useful tool for monitoring patient-reported changes that reflect cardiac function.
Learning to Optimize via Information-Directed Sampling
Authors: Russo Daniel , Van Roy Benjamin 
Published: October 2017

We propose information-directed sampling—a new approach to online optimization problems in which a decision maker must balance between exploration and exploitation while learning from partial feedback. Each action is sampled in a manner that minimizes the ratio between squared expected single-period regret and a measure of information gain: the mutual information between the optimal action and the next observation. We establish an expected regret bound for information-directed sampling that applies across a very general class of models and scales with the entropy of the optimal action distribution. We illustrate through simple analytic examples how information-directed sampling accounts for kinds of information that alternative approaches do not adequately address and that this can lead to dramatic performance gains. For the widely studied Bernoulli, Gaussian, and linear bandit problems, we demonstrate state-of-the-art simulation performance. The electronic companion is available at https://doi.org/10.1287/opre.2017.1663 .
The culture of permadeath: Roguelikes and Terror Management Theory
Authors: Parker Rob 
Published: October 2017

Abstract
In this exploratory article, Rob Parker examines the function of permadeath in the roguelike subgenre of computer role-playing games (cRPGs) through the lens of Terror Management Theory (TMT). In doing so, he provides a broad history of the subgenre, with specific attention to providing a productive distinction between modern and traditional roguelikes that lies in how they handle permadeath. He suggests that this focus on permadeath is one of the primary motivating factors for the resilience of the roguelike community over time, and what the implications of those motivations might mean for other members of the gaming community.
Nutrient Condition of Kampar Big River Estuary: Distribution of N and P Concentrations Drifted by Tidal Bore ”Bono”
Authors: Wisha Ulung Jantama , Maslukah Lilik 
Published: October 2017

Due to accelerated anthropogenic activity, a significant amount of pollutants has been directly or indirectly discharged into coastal estuaries of Kampar. Nutrient pollution along the river to the estuary that adversely affects coastal and estuary ecosystem mainly originates from inland such as industrial effluent, household, and agricultural waste as well as a naturally derived pollutant from biogeochemical cycle, which is controlled by the propagation of undular bore (Bono). The purpose of this study is to determine the environmental impact of distribution of nutrients caused by the mechanism of Bono. This research employed a purposive quantitative method, the concentration of dissolved phosphate, nitrate, nitrite and ammonia was analyzed using a spectrophotometer, tidal data retrieval was measured for 30 days’ near the estuarine area, while, current flow was measured for 24 hours’ measurement. Phosphate concentrations ranged from 0.02-0.1 mg.L-1, nitrate concentrations ranged from 0.76-5.73 mg.L-1, ammonia concentrations ranged from 0.2-0.41 mg.L-1, nitrate concentrations ranged from 0.001-0.03 mg.L-1. The tidal type is mixed tide prevailing semidiurnal with tidal range reach 4.2 m during spring tide condition. At the time of Bono propagate, drastically enhance the surface elevation and directly increase the drift of velocity with the flow direction from estuary into the river upstream, that mechanism affects the nutrient distribution in Kampar river. Keywords: Bono, Fluid dynamics, Nutrient distribution, Tidal bore, Water quality
A Presynaptic Function of Shank Protein inDrosophila
Authors: Wu Song , Gan Guangming , Zhang Zhiping , Sun Jie , Wang Qifu , Gao Zhongbao , Li Meixiang , Jin Shan , Huang Juan , Thomas Ulrich , Jiang Yong-hui , Li Yan , Tian Rui , Zhang Yong Q. 
Published: October 2017

Human genetic studies support that loss-of-function mutations in theSH3 domain andankyrin repeat containing family proteins (SHANK1-3), the large synaptic scaffolding proteins enriched at the postsynaptic density of excitatory synapses, are causative for autism spectrum disorder and other neuropsychiatric disorders in humans. To better understand thein vivofunctions of Shank and facilitate dissection of neuropathology associated withSHANKmutations in human, we generated multiple mutations in theShankgene, the only member of the SHANK family inDrosophila melanogaster. Both male and femaleShanknull mutants were fully viable and fertile with no apparent morphological or developmental defects. Expression analysis revealed apparent enrichment of Shank in the neuropils of the CNS. Specifically, Shank coexpressed with another PSD scaffold protein, Homer, in the calyx of mushroom bodies in the brain. Consistent with high expression in mushroom body calyces,Shankmutants show an abnormal calyx structure and reduced olfactory acuity. These morphological and functional phenotypes were fully rescued by pan-neuronal reexpression of Shank, and only partially rescued by presynaptic but no rescue by postsynaptic reexpression of Shank. Our findings thus establish a previously unappreciated presynaptic function of Shank.SIGNIFICANCE STATEMENTMutations inSHANKfamily genes are causative for idiopathic autism spectrum disorder. To understand the neural function of Shank, a large scaffolding protein enriched at the postsynaptic densities, we examined the role ofDrosophilaShank in synapse development at the peripheral neuromuscular junctions and the central mushroom body calyx. Our results demonstrate that, in addition to its conventional postsynaptic function, Shank also acts presynaptically in synapse development in the brain. This study offers novel insights into the synaptic role of Shank.
“A History of Man and His Desire”: Ferruccio Busoni and Faust
Authors: Knyt Erinn 
Published: October 2017

Relying on knowledge of Karl Engel's edition of the Volksschauspiel, Karl Simrock's version of the puppet play, Gotthold Lessing's Faust fragments, and versions of the Faust legend by Christopher Marlowe and Johann Wolfgang von Goethe, among others, Ferruccio Busoni crafted his own hybrid libretto that depicts a mystical and broadminded Faust. Busoni's music reflects the richness of Faust's mind, combining heterogeneous timbres, forms, and styles. Busoni juxtaposes a Gregorian Credo, Palestrina-style choral settings, a reformation hymn, a Baroque instrumental dance suite, an organ fantasia, recitatives, a lyrical ballad, and orchestral variations, with impressionistic symphonic writing, and experimental passages. While stylistic heterogeneity can be heard throughout many of his mature instrumental and vocal works, Busoni also used this heterogeneity in a descriptive way in Doktor Faust to characterize Faust.
At the same time, Busoni sought to write “a history of man and his desire” rather than of a man and the devil. It is Faust's own dark side, rather than the devil, that distracts him and prevents him from completing his greatest work. With Kaspar removed from the plot, Mephistopheles, who as spirit is not always distinct from Faust the man, becomes Faust's alter ego. This duality is expressed musically when Faust assumes Mephistopheles's characteristic intervals.
Although Busoni's incomplete Doktor Faust, BV 303, has already been studied by several scholars, including Antony Beaumont, Nancy Chamness, and Susan Fontaine, there is still no detailed analysis of Busoni's treatment of Faust. Through analyses of autobiographical connections, Busoni's early settings of Faustian characters, and the text and music in Doktor Faust, with special attention on the Wittenberg Tavern Scene that has no precedent among the versions of the Faust legend, this article reveals Busoni's vision of Faust as a broadminded, and yet conflicted character, shaped idiosyncratically to convey Busoni's personal artistic ideals. In so doing, the article not only contributes to ongoing discourse about Doktor Faust, but also expands knowledge about ways the Faust legend was interpreted and set musically in the early twentieth century through intertextual comparisons.
RISCOS OCUPACIONAIS E SUAS REPERCUSSÕES NOS PROFISSIONAIS DE ENFERMAGEM NO ÂMBITO HOSPITALAR
Authors: Oliveira Maira Matos , De Andrade Nina Vieira , Brock Jordana 
Published: October 2017

Objetivo: verificar as repercussões dos riscos ocupacionais nos profissionais de enfermagem que atuam em área hospitalar. Métodos: revisão integrativa entre os anos de 2010 a 2016, nas bases de dados SciELO, MEDLINE, LILACS, BDENF e IBECS. Os critérios de inclusão foram: publicações em português, inglês e espanhol; artigos disponíveis na íntegra e gratuitos; publicações relacionadas ao objeto de estudo. Os critérios de exclusão foram: Monografias, dissertações, teses; artigos de revisão, opinião e reflexão; artigos que se repetiram nas bases de dados; artigos que se referem aos profissionais da atenção básica; artigos que tratam dos demais profissionais de saúde. A análise do material foi feita através da Análise Temática de Bardin. Resultados: Após a leitura dos artigos emergiram três categorias: 1) Perfil epidemiológico da população estudada; 2) Repercussões do risco biológico para os profissionais de enfermagem; 3) Demais riscos e repercussões. Conclusão: A análise mostrou que a maneira como é organizado o trabalho de enfermagem a nível hospitalar bem como seu processo, são os maiores causadores de exposição a riscos ocupacionais aos trabalhadores, e como maior consequência dessa exposição está o adoecimento seja físico ou psíquico dos mesmos.
Effect of dentifrices containing sorbitol, combination of xylitol and sorbitol on salivary Streptococcus mutans and Lactobacillus counts in 14-15 year old children: a randomized trial
Authors: R. Shwetha , S. Vivek 
Published: October 2017

<p class="abstract"><strong>Background:</strong> Xylitol, a naturally occurring sugar alcohol which cannot be fermented by oral microorganisms has been shown to reduce <em>Streptococcus</em> <em>mutans</em> levels in plaque and saliva and to markedly reduce tooth decay. Studies have proved that combination of xylitol and sorbitol added in chewing gum is more effective in reducing tooth decay compared to xylitol alone. Purpose<strong> </strong>of this double blinded, parallel, randomized trial was to compare the relative effect of sorbitol and combination of xylitol and sorbitol containing dentifrices on salivary <em>Streptococcus mutans</em> and <em>Lactobacillus</em> in a group of high school children.</p><p class="abstract"><strong>Methods:</strong> Sixty school children with age group of 14-15 years were randomly allocated into 2 study groups (S-sorbitol containing dentifrice and X+S- Xylitol and Sorbitol containing dentifrice), with 32 participants in each group. Subjects were asked to use the experimental dentifrices twice daily for 3 months period. Resting whole saliva was collected at baseline, at the end of 1 month, 2 months and 3 months interval after the use of assigned dentifrice. Saliva samples were used for microbial analysis. <em>Streptococcus mutans </em>was cultured on Mitis salivarius bacitracin agar and <em>Lactobacilli</em> on Rogosa SL agars. Results were expressed in frequencies. Nonparametric tests namely Wilcoxons-signed rank test and Mann Whitney U test were used for testing the statistical significance. The level of significance was set at p=0.05.</p><p class="abstract"><strong>Results:</strong> There was no significant difference in salivary <em>Streptococcus mutans</em> count amongst the two groups at baseline (p=0.271). There was no significant difference in counts of <em>Streptococcus mutans</em> and lactobacilli among the subjects in the sorbitol containing dentifrices (S) group at different time intervals of the study whereas there was significant reduction in counts of <em>Streptococcus mutans</em> and <em>Lactobacillus</em> count among the subjects in the xylitol and sorbitol (X+S) containing dentifrices at all the time interval. At the end of 3<sup>rd</sup> month interval there was significantly low <em>Streptococcous mutans </em>and lactobacilli count for X+S group compared to S group with p&lt;0.001 and p=0.02 respectively. </p><p><strong>Conclusions:</strong> The use of dentifrices containing combination of xylitol and sorbitol, twice daily showed significant antimicrobial properties against salivary <em>Streptococcus mutans</em> and <em>lactobacillus</em> by the end of 3 month compared to sorbitol containing dentifrice.</p>
Clinical study of branch retinal vein occlusion
Authors: Kumar Sonali V. 
Published: October 2017

<p class="abstract"><strong>Background:</strong> Many large case series about demographic characteristics and association of branch retinal vein occlusion (BRVO) with systemic diseases have been published in the western population. However this pattern of demographic characteristics in the developed countries may not be representative of epidemiology of disease in the developing countries because of the real paucity of reports from these areas. The study is therefore aimed at evaluating demographic characteristics, to identify the common systemic or ocular risk factors and common clinical presentation of BRVO patients<span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> Hundred consecutive newly diagnosed cases of BRVO were included in this study. A complete ophthalmic evaluation was done after obtaining informed consent. A complete history both ocular and medical with emphasis on hypertension, diabetes and symptoms concerning glaucoma were taken<span lang="EN-IN">.</span></p><p class="abstract"><strong>Results:</strong> Out of 100 patients 80 were males and 20 were females. Average age of total patients was 62. Commonest mode of presentation was diminution of vision in 80 patients followed by floaters in 10 patients. About 10 patients were asymptomatic at the time of presentation. Out of 100 patient 80 were hypertensives, 10 were diabetics and deranged lipid level was found in 38 patients. Raised imtraocular pressure (IOP) was found in 10 patients, shorter axial length in 40 and no other ocular association was found in 50 patients<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> From this study we conclude that it is a disease of elderly age group and hypertension, hyperlipidaemia, shorter axial length are associated risk factors in patients with BRVO and must be looked for in such cases.</p>
Integrating mHealth into adolescent sexual and reproductive health promotion in Nigeria: prospects and barriers
Authors: Ihesie Chukwuemeka Austin , Chukwuogo Ogoamaka 
Published: October 2017

Adolescent sexual and reproductive health (ASRH) is a key public health issue because of its impact on health and development. Adolescent SRH is linked to available information which often determines sexual behaviours. The use of mobile phones for health (mHealth) has shown success in delivering health education and behaviour change interventions for young people for smoking cessation, nutrition and in SRH. This article explores the possible prospects and barriers to the use of mHealth for ASRH promotion in Nigeria. This paper reviews secondary data from international and local literature obtained from database search. A conceptual framework and an applicability and transferability (A&T) tool guided the analysis of ASRH issues and feasibility of mHealth use in ASRH in Nigeria. The prospects of mHealth use for ASRH in Nigeria include the widespread coverage of mobile phone services and the acceptability of its use for health by Nigerian adolescents, unmet need in ASRH information provision and the similarity of some characteristics of Nigerian adolescents to other study populations where mHealth has been successfully used. Other prospects include the Nigerian government’s focus on ICT solutions and the availability of essential technical and organisational expertise for implementation. Possible barriers to the successful use of mHealth include poor funding for ASRH and inadequate information on implementation costs and cost-effectiveness which may make it difficult to present a business case. In conclusion, the use of mHealth in ASRH promotion in Nigeria is feasible and can be effective, however, measures must be taken to address specific barriers identified.
To analyze the functional outcome of proximal tibial fractures treated with minimally invasive percutaneous plate osteosynthesis technique
Authors: Arumugam Sivakumar , Arumugam Venkateshwara , Raviraman V. 
Published: October 2017

<p class="abstract"><strong>Background:</strong> Tibial plateau fractures constitute about 1% of all fractures and complex bicondylar fractures constitute 30% of all Tibial plateau fractures. Minimally Invasive Percutaneous Plate Osteosynthesis [MIPPO] is a method of biological fixation in which a plate is percutaneously inserted and fixed at a distance proximally and distally from the fracture site. By minimal exposure, this helps in the preservation of the essential fracture hematoma, minimal soft tissue dissection, avoidance of periosteal stripping and providing an adequate fixation. The objective of the study was to analyze the functional outcome of proximal Tibial fractures treated with MIPPO technique. The method of fixation shall be evaluated for the time period required for the patients to return to active work following surgery.</p><p class="abstract"><strong>Methods:</strong> In our study, all 18 patients with proximal Tibial fractures underwent definitive fixation by MIPPO technique. All our cases underwent initial stabilization as per the ATLS guidelines. Patients with closed Tibial plateau fractures associated with a tense haemarthrosis underwent aspiration of the joint under aseptic precautions. The limb was immobilized either in an above knee slab or through skeletal traction using a distal Tibial or calcaneal pin traction on a Bohler Braun splint until definitive fixation was carried out. In cases complicated with excessive swelling and blistering, definitive fixation was delayed until the swelling/ blistering subsided.<strong></strong></p><p class="abstract"><strong>Results:</strong> The post-operative results were designated as excellent, good, fair and poor according to pain, walking capacity, the range of motion and stability of the knee using Rasmussen’s grading system. In our study, the average functional knee score was 22.89. Rasmussen’s score does not consider articular congruity while assessing the functional outcome of the knee.</p><p class="abstract"><strong>Conclusions:</strong> MIPPO technique gives good to excellent results even in high energy Tibial condyle fractures [72.22% cases in our study]. Our patients were able to achieve a good functional range of movement, averaging 120 degrees. [Krettek et al – 124 degrees]. Those who were treated with early fixation and early mobilization were found to have a better functional outcome irrespective of the fracture type. No secondary bone grafting was required. </p>