bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges With Research Contract Negotiations in Community-Based Cancer Research
Authors: Thompson Michael A. , Hurley Patricia A. , Faller Bryan , Longinette Jean , Richter Katie , Stewart Teresa L. , Robert Nicholas 
Published: June 2016

Purpose: Community-based research programs face many barriers to participation in clinical trials. Although the majority of people with cancer are diagnosed and treated in the community setting, only roughly 3% are enrolled onto clinical trials. Research contract and budget negotiations have been consistently identified as time consuming and a barrier to participation in clinical trials. ASCO’s Community Research Forum conducted a survey about specific challenges of research contract and budget negotiation processes in community-based research settings. The goal was to ultimately identify potential solutions to these barriers. Methods: A survey was distributed to 780 community-based physician investigators and research staff. The survey included questions to provide insight into contract and budget negotiation processes and perceptions about related barriers. Results: A total of 77% of the 150 respondents acknowledged barriers in the process. Respondents most frequently identified budget-related issues (n = 133), inefficiencies in the process (n = 80), or legal review and negotiation issues (n = 70). Of the respondents, 44.1% indicated that contract research organizations made the contract negotiations process harder for their research program, and only 5% believed contract research organizations made the process easier. The contract negotiations process is perceived to be impeded by sponsors through underestimation of costs, lack of flexibility with the contract language, and excessive delays. Conclusion: Improving clinical trial activation processes and reducing inefficiencies would be beneficial to all interested stakeholders, including patients who may ultimately stand to benefit from participation in clinical trials. The following key recommendations were made: standardization of contracts and negotiation processes to promulgate transparency and efficiencies, improve sponsor processes to minimize burden on sites, create and promote use of contract templates and best practices, and provide education and consultation.
Metabolite profile of a mouse model of Charcot–Marie–Tooth type 2D neuropathy: implications for disease mechanisms and interventions
Authors: Bais Preeti , Beebe Kirk , Morelli Kathryn H. , Currie Meagan E. , Norberg Sara N. , Evsikov Alexei V. , Miers Kathy E. , Seburn Kevin L. , Guergueltcheva Velina , Kremensky Ivo , Jordanova Albena , Bult Carol J. , Burgess Robert W. 
Published: June 2016

ABSTRACT
Charcot–Marie–Tooth disease encompasses a genetically heterogeneous class of heritable polyneuropathies that result in axonal degeneration in the peripheral nervous system. Charcot–Marie–Tooth type 2D neuropathy (CMT2D) is caused by dominant mutations in glycyl tRNA synthetase (GARS). Mutations in the mouse Gars gene result in a genetically and phenotypically valid animal model of CMT2D. How mutations in GARS lead to peripheral neuropathy remains controversial. To identify putative disease mechanisms, we compared metabolites isolated from the spinal cord of Gars mutant mice and their littermate controls. A profile of altered metabolites that distinguish the affected and unaffected tissue was determined. Ascorbic acid was decreased fourfold in the spinal cord of CMT2D mice, but was not altered in serum. Carnitine and its derivatives were also significantly reduced in spinal cord tissue of mutant mice, whereas glycine was elevated. Dietary supplementation with acetyl-L-carnitine improved gross motor performance of CMT2D mice, but neither acetyl-L-carnitine nor glycine supplementation altered the parameters directly assessing neuropathy. Other metabolite changes suggestive of liver and kidney dysfunction in the CMT2D mice were validated using clinical blood chemistry. These effects were not secondary to the neuromuscular phenotype, as determined by comparison with another, genetically unrelated mouse strain with similar neuromuscular dysfunction. However, these changes do not seem to be causative or consistent metabolites of CMT2D, because they were not observed in a second mouse Gars allele or in serum samples from CMT2D patients. Therefore, the metabolite ‘fingerprint’ we have identified for CMT2D improves our understanding of cellular biochemical changes associated with GARS mutations, but identification of efficacious treatment strategies and elucidation of the disease mechanism will require additional studies.
Asymmetric Synthesis of Cyclopropylmethanamines by Rhodium-catalyzed Cyclopropanation of Pinacol Allylboronate with N-Sulfonyl-1,2,3-triazoles
Authors: Miura Tomoya , Nakamuro Takayuki , Nikishima Hiroki , Murakami Masahiro 
Published: June 2016

Abstract
Herein, the rhodium(II)-catalyzed cyclopropanation reaction of pinacol allylboronate with N-sulfonyl-1,2,3-triazoles is reported. Boryl-substituted cyclopropylmethanamines are produced in a highly diastereo- and enantioselective manner. Various cyclopropylmethanamines containing a quaternary stereocenter are derived from them.
Prevalence and risk factors of depressive episodes among student population in Wroclaw – epidemiological study results
Authors: Zagdańska Marta , Kiejna Andrzej 
Published: June 2016

Cel pracyCelem badania było oszacowanie rozpowszechnienia epizodów depresyjnych w populacji studentów stacjonarnych publicznych uczelni wyższych we Wrocławiu. Dążono również do zidentyfikowania cech demograficznych, stanowiących czynniki ryzyka zaburzeń depresyjnych.MetodaZastosowano polską adaptację Złożonego Międzynarodowego Kwestionariusza Diagnostycznego (CIDI). Przebadano 370 studentów studiów stacjonarnych. Charakterystyka próby odzwierciedlała strukturę populacji pod względem płci, roku i trybu studiów oraz kierunków kształcenia. Randomizację zapewniono poprzez losowość procedur doboru respondentów do badania.WynikiPotwierdzono znaczne rozpowszechnienie epizodów depresji zarówno w ciągu całego życia (14,7%), jak i w roku poprzedzającym pomiar (9,8%). Niepokój budzą wysokie wskaźniki częstości epizodów depresyjnych o znacznym i umiarkowanym nasileniu (w całym życiu odpowiednio 5,1% i 6,6%, w minionych 12 miesiącach 3,8% i 3,9%). Etap i kierunek kształcenia oraz brak stałej relacji partnerskiej stanowią istotne czynniki ryzyka depresji.WnioskiZnaczne rozpowszechnienie epizodów depresyjnych wskazuje na konieczności podjęcia działań prewencyjnych i terapeutycznych dopasowanych do potrzeb i opartych o dane epidemiologiczne. Depresja wśród młodzieży akademickiej wymaga dalszych badań epidemiologicznych.
MABS: targeted therapy tailored to the patient's need
Authors: Miedany Yasser El 
Published: June 2016

Monoclonal antibodies (MABs) represent the window of opportunity in modern medicine. As immunology plays a vital role both in our survival and in disease development, MABs were found to be of great help in diagnosing, prognosticating and managing certain malignancies, inflammatory conditions, autoimmune as well as infectious diseases. Technological advances have enabled the production of MABs that target specific antigens linked with several disease processes. These drugs are now a component of therapy, not only for many common malignancies, including breast, colorectal, lung and pancreatic cancers, as well as lymphoma, leukaemia and multiple myeloma, but also for several inflammatory conditions such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and inflammatory bowel disease. Targeted therapy has raised new questions about tailoring treatment, including cancer management, to the individual patient's needs. This would have a positive impact on the drug's effectiveness and toxicity, as well as the economics of care. While targeted MABs are generally better tolerated than traditional chemotherapy, they are associated with several adverse effects, which vary from one patient to another
Effects of methylene-blue staining on the extent of pilonidal sinus excision
Authors: Ardelt M. , Kocijan R. , Dittmar Y. , Fahrner R. , Rauchfuss F. , Scheuerlein H. , Settmacher U. 
Published: June 2016

Objective: We aimed to examine the effects of methylene-blue staining (MBS) on the volume of specimens after excision of pilonidal sinuses. Method: This was a retrospective analysis of 135 excised specimens after pilonidal sinus (PS) surgery. All patients underwent procedures at the Department of Surgery of University Hospital Jena between 2000 and 2010. All specimens were measured in three dimensions. To calculate the volumes of excised specimens, we used a model of a hemi-ellipsoid. Demographic information (age, height, weight, body mass index, smoking status) were also obtained for all patients. Results: Excised specimens with MBS had significantly larger volumes (p<0.001) as reflected in length (p=0.001), width (p=0.001), and depth (p=0.017) of the excised specimen compared with specimens that were not stained with methylene blue (MB). In addition, the volume was larger in subjects with a recurrent PS (p=0.021), which was predominantly the case in female subjects (p=0.025). Conclusion: These data suggest that excised specimens with MBS had significantly larger volumes of the excised specimen compared with specimens that were not stained with MB. MBS of a fistula system could enable such a system to be marked sufficiently, thereby facilitating complete resection of a PS. Declaration of interest: The authors declare no conflict of interest.
Negative pressure wound therapy in the early period after hand and forearm replantation, is it safe?
Authors: Dadaci M. , Isci E. T. , Ince B. , Altuntas Z. , Evrenos M. K. , Uzun H. , Sönmez E. , Bitik O. 
Published: June 2016

Objective: In this study, effectiveness and reliability of negative pressure wound therapy (NPWT) in the early period after replantation will be examined retrospectively in a series of patients. Method: Patients who underwent replantation between 2007 and 2014, and had tissue defect or partial necrosis in the absence of a major circulation problem were included in this retrospective study. Following debridement of necrotic tissues on the postoperative 7–10 days, NPWT was applied to all patients one day later and adjusted as intermittent 75 mmHg pressure. Intermittent phase adjustment was arranged as 5 minutes suction and 2 minutes resting, and resting pressure was adjusted as 35 mmHg. NPWT was applied for six days and dressings were changed in every three days in the first six day period. Open wounds was debrided again and grafted with split-thickness skin graft and NPWT was continued over the graft for 4 days more. Results: There were 11 patients included of which nine amputations were complete and two were nearly total amputations of forearm. Granulation tissue was observed following 6 days of NPWT application in all patients. Graft survival was observed to be almost complete. Wound infection did not occur and tissue cultures obtained in the course of debridement were all negative. Partial oxygen saturations were between 96–99% during the NPWT. Conclusion: NPWT (75 mmHg) can be used in the intermittent mode in order to improve wound healing and shorten the period to start physical therapy in the early period after replantation and revascularisation. Declaration of interest The authors have no conflict of interest.
Pyoderma gangrenosum mimicking mediastinitis after cardiac surgery: a case study
Authors: Hysi I. , Vincentelli A. 
Published: June 2016

Pyoderma gangrenosum is a dermatosis which associates both, necrosis and polynuclear infiltration of the skin. While the aetiology is not well understood, the disease is thought to be due to immune system dysfunction and it can occur after minor trauma or surgery. Although it has seldom been reported after cardiac surgery in the literature, it is not exceptional. Here we report a case of pyoderma gangrenosum after coronary artery bypass grafting in a 76-year-old patient with chronic idiopathic myelofibrosis. Diagnosis was clinically made and the patient was treated with systemic steroids. The lesions showed a remarkable improvement with this therapy. In the field of cardiac surgery, physicians of the surgical team and nurses should think about this diagnosis in all rapidly expanding postoperative lesions without improvement after debridement or antibiotics. Declaration of interest: The authors have no conflicts of interest to declare.
Contemporaneity and micropolitics in the processes of Perception Frames
Authors: Irvine Rosanna 
Published: June 2016

Abstract
The article discusses the written work Perception Frames, a collection of choreographic scores, which is one creative outcome of the author’s larger research project addressing non-representational poetics of twentyfirst-century western choreography. This project takes Gilles Deleuze’s critique of representation and his concern with thinking without recourse to recognition as provocation, orientating these concerns to the practices of choreography. The article gives an account of the research activities undertaken in the development of Perception Frames, followed by an explanation and discussion of its written structure. The perspective of practice is privileged in the articulation of the (experiential) perceptual sensing processes through which Perception Frames operates. The article argues that the scores generate conditions for modes of nonrepresentational thinking on the part of the performer: modes of thinking that operate through the conjoined and processual operations of agency and relations, in an immediacy of perceptual sensing, so producing the choreographic event. The article concludes with the suggestion that the scores stage contemporaneity, understood as a being-with time, and that they offer means for practising a micropolitics of producing in the immediacy of occurring relations.
Recognizing the NOW in UK Contemporary Dance
Authors: Butcher Rosemary , Hicks Claire 
Published: June 2016

Abstract
This transcript replicates Rosemary and Claire’s use of series of (perhaps) contentious statements as a starting point for dialogue around Contemporary Dance in the United Kingdom, which formed a keynote presentation at the Questioning the Contemporary in 21st Century British Dance Practices Symposium (July, 2014). Thinking of the future, they reflect back but mainly ask about what we are doing now and why, since one cannot make work for the future but only for the present. Both believe in the possibility of a truly Contemporary Dance sector in the United Kingdom and bring their own perspectives as practitioners to it – as artist and producer, respectively. How do our systems, knowledge and beliefs impact upon the work we create, the work we value and the way we support and nurture our most important asset, our artists?
The identity of hybrid dance artist-academics working across academia and the professional arts sector
Authors: Doughty Sally , Fitzpatrick Marie 
Published: June 2016

Abstract
This article reports on interim findings from an evolving research project that sets out to examine and document the experiences of hybrid dance artist-academics working across academia and the professional arts sector. Three round table events and an online conversation enabled the capturing of voices of those who operate in academia and the professional arts sector in response to the research project’s three main aims:
• To understand the experiences of the hybrid dance artist-academic
• To shed light upon the contextual factors that shape these experiences
• To offer recommendations that may support a productive, creative practice environment for the hybrid dance artist-academic.
This article further contextualizes commentaries within wider discourse on artistic practice and/or Practice as Research (PaR), such as those from Practice as Research in Performance (PARIP) and the Centre for Research into Creation in the Performing Arts (ResCen). The relationship between arts-making practices and neo-liberalist frameworks is explored. The emergent issues of hierarchies, dissidence and the epistemology of the hybrid dance artist-academic are presented and conceptions of agency and community are reconsidered.
The end of choreography
Authors: Hildebrandt Antje 
Published: June 2016

Abstract
The End of Choreography is a commissioned video (2013, https://vimeo.com/80257439), a lecture presentation (2015) and a performative essay (2016). As a PaR project concerned with choreography in the expanded field, these multiple manifestations problematize the notion of the artwork, questioning what impact context has on the reading and the meaning of a work. In this provocation I mix images with written text, use references from different disciplines and historical eras, quote well-known international theorists and philosophers alongside local choreographers and dance practitioners. I also refer to pieces I have seen, read about and participated in. Thus, I create a variety of contexts and reference points, questioning the meaning, value and purpose of choreography at the beginning of the twenty-first century. For this written version of The End of Choreography I collaborated with a graphic designer to present the work in a different medium, exploring the potentialities of translating the video onto the page as a textual document. Rather than presenting a closed argument, my aim is to trigger a debate about the current state of affairs in the field, whether this be the end, or future, of choreography.
Upper Airway Control in Airway Defense
Authors: Poliacek I , Simera M , Calkovsky V , Jakus J 
Published: June 2016

Abstract
Upper airways (UA) are an organic component of the respiratory tract, they serve to respiration, respiratory tract protection and defense, phonation, deglutition, etc. The functions of UA are regulated by motor control of the oral, pharyngeal, and laryngeal muscles.
UA typically stiffen and widen during inspiration mainly due to the activation of the alae nasi, genioglossus m., pharyngeal dilators, and laryngeal abductors. These and other UA muscles (e.g. laryngeal and pharyngeal constrictors) may express varoius activity patterns, actively shaping UA depending on species, arousal, respiratory drive, and behavior being executed. E.g. during coughing and sneezing laryngeal movement consists of abductions in inspiration and expiration and adductions in compression and subsequent constriction phase. The cricopharyngeus m., in cough expiration the superior pharyngeal constrictor and in the sneeze expiration the styloglossus and levator veli palatini m. are activated. Unlike in breathing or coughing, where UA serve to respiration-protection-defense, the pharyngeal phase of swallowing is essentially made by the coordinated action of a number of UA muscles.
Motoneurons driving the UA muscles are located primarily in the hypoglossal and ambigual nuclei. Motor pattern of individual motoneuronal pools is determined by activation-inhibition-modulation from pre-motoneurons and other upstream neurons of the reflex circuits. Laryngeal and hypoglossal nerve activity is during breathing under command of respiratory central pattern generator. UA muscles are driven in inspiration primarily from augmenting, less from decrementing and constant inspiratory neurons. Number of additional inputs is involved in UA regulation during expirations and other motor behaviors. Anatomical and functional studies pointed out number of brainstem areas, such as the regions of solitary tract nucleus, hypoglossal ncl., trigeminal ncl., lateral tegmental field, raphé, the ventral and ventrolateral medulla, pontine parabrachial region, etc. with neurons related to UA motor control.
Abundant connectivity of the neuronal network that controls UA patency employs almost all kind of receptors and neurotransmitter/neuromodulator systems. Among large number of diseases and disorders that relate to UA, primarily cholinergic, norepinephrine, and serotonergic tonic drives are implicated in those resulted from the reduced UA tone. Pharmacological and frequently simple surgical interventions may improve these conditions (snore, obturation) in patients. Recently, besides medicinal treatment, conditional procedures incorporating an exercise and practice, stimulation of appropriate afferent pathways, and combining reflex responses may offer promising therapies.
Methyl- and methoxysalicylatocopper complexes with 2-ethylbenzimidazole
Authors: Puchoňová Miroslava , Kuchtanin Vladimír , Mazúr Milan , Valigura Dušan 
Published: June 2016

Abstract
Four new compounds of formulae [Cu(3-Mesal)2(etbzim)2] (1), [Cu(4-Mesal)2(etbzim)2] (2), [Cu(4-MeOsal)2(etbzim)2] (3), [Cu(5-MeOsal)2(etbzim)2] (4) where 3- or 4-Mesal = 3- or 4-methylsalicylate anionic ligand, 4- or 5-MeOsal = 4- or 5-methoxysalicylate anionic ligand, etbzim = 2-ethylbenzimidazole) have been prepared and characterised by elemental analysis and available spectral methods (EPR, UV-vis and IR spectra). EPR spectra of all measured complexes are axial symmetry. Other spectral methods led to conclusion that all prepared complexes probably contain the etbzim ligand coordinated in equatorial plane together with the asymmetrically bonded salicylato anions thus giving {CuN2O2O’O”} chromophore. The supposed structural motive for all prepared complexes might be simmilar to those benzoate complexes with benzimidazole [Cu(4-OHbz)2(bzim)2] and [Cu(4-Mebz)2(bzim)2] (4-OHbz = 4-hydroxybenzoate, 4-Mebz = = 4-methylbenzoate), but similarity with polymeric salicylate complex [Cu(sal)2(bzim)2]n cannot be excluded.
Water liquid-vapor equilibrium by molecular dynamics: Alternative equilibrium pressure estimation
Authors: Ilčin Michal , Michalík Martin , Kováčiková Klára , Káziková Lenka , Lukeš Vladimír 
Published: June 2016

Abstract
The molecular dynamics simulations of the liquid-vapor equilibrium of water including both water phases — liquid and vapor — in one simulation are presented. Such approach is preferred if equilibrium curve data are to be collected instead of the two distinct simulations for each phase separately. Then the liquid phase is not restricted, e.g. by insufficient volume resulting in too high pressures, and can spread into its natural volume ruled by chosen force field and by the contact with vapor phase as vaporized molecules are colliding with phase interface. Averaged strongly fluctuating virial pressure values gave untrustworthy or even unreal results, so need for an alternative method arisen. The idea was inspired with the presence of vapor phase and by previous experiences in gaseous phase simulations with small fluctuations of pressure, almost matching the ideal gas value. In presented simulations, the first idea how to calculate pressure only from the vapor phase part of simulation box were applied. This resulted into very simple method based only on averaging molecules count in the vapor phase subspace of known volume. Such simple approach provided more reliable pressure estimation than statistical output of the simulation program. Contrary, also drawbacks are present in longer initial thermostatization time or more laborious estimation of the vaporization heat. What more, such heat of vaporization suffers with border effect inaccuracy slowly decreasing with the thickness of liquid phase. For more efficient and more accurate vaporization heat estimation the two distinct simulations for each phase separately should be preferred.