bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of acid mine drainage on clay minerals suspended in the Tinto River (Río Tinto, Spain). An experimental approach
Authors: Galan E. , Carretero M. I. , Fernandez-Caliani J . C. 
Published: July 2002

AbstractThe Tinto river is one of the most polluted stream environments in the world, as a result of both acid mine drainage and natural acid rock drainage. Two representative samples from the phyllosilicate-rich rocks exposed in the drainage basin (Palaeozoic chlorite-bearing slates and Miocene smectite-rich marls) were treated with acid river water (pH = 2.2) for different times to constrain the effects of extreme hydrogeochemical conditions on clay mineral stability. Illite and kaolinite did not show appreciable variations in their crystal chemistry parameters upon treatment. Chlorite underwent an incipient chemical degradation evidenced by the progressive loss of Fe in octahedral positions coupled with a shortening of the b unit-cell parameter, although no weathering products of chlorite were observed. Smectite and calcite were rapidly and fully dissolved thus neutralizing the water acidity, and subsequently Fe and Al oxy-hydroxides and opaline silica precipitated from the aqueous solution, together with a neoformed amorphous silicate phase largely enriched in Al and Mg.
Gradual H/D substitution in synthetic germanium bearing talcs: a method for infrared band assignment
Authors: Martin F. , Petit S. , Grauby O. , Lavie M. P. 
Published: July 2002

AbstractThe deuteration technique was used to assign unknown infrared (IR) bands of Ge-bearing talcs. Procedures to achieve partial or complete H/D replacement in synthetic Ge-bearing (Mg, Ni and Co)-talcs have been investigated. From the spectral shift of IR absorption bands in the 4000–300 cm-1 region resulting from the H-D substitution, the IR bands of vibrations of Ge-bearing talcs could be identified and synthetic Ge-bearing talcs showed significantly different IR spectra from those for Si-talcs. After deuteration of synthetic Ge-bearing talcs, the unknown bands were attributed either to hydroxyl groups or to Ge–O vibrations of the clay skeleton, and the spectra were interpreted fully.
Petrogenesis of plagioclase phenocrysts of Mount Etna, Sicily, with particular reference to the 1983 eruption: contribution from cathodoluminescence petrography
Authors: Stirling D. , Duncan A. M. , Guest J. E. , Finch A. A. 
Published: July 2002

AbstractThe cathodoluminescence (CL) characteristics of plagioclase phenocrysts in water-quenched lavas from the 1983 eruption of Etna have been investigated to examine the application of plagioclase CL to the study of magmatic processes. The phenocrysts have a green luminescent inner zone that is sharply bounded by a blue luminescent outer zone, with the boundary often coinciding with a concentric zone of glass inclusions.Strong compositional differences between the green (An70–An75) and blue (An50–An60) luminescent areas are interpreted as the result of two phases of growth under differing conditions. The green luminescent cores are considered to be anorthite-rich cumulate crystals from a basic magma which have been disrupted by the injection of a more evolved melt, resulting in heterogeneous nucleation and crystallization of the outer blue luminescent zone. The relationship between the CL and the trace element contents of the plagioclase crystals is discussed.
mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit–erythroid development
Authors: Geiger Justin N. , Knudsen Geoffry T. , Panek Leigh , Pandit Ajay K. , Yoder Michael D. , Lord Kenneth A. , Creasy Caretha L. , Burns Brian M. , Gaines Peter , Dillon Susan B. , Wojchowski Don M. 
Published: July 2002

AbstractDYRKs are a new subfamily of dual-specificity kinases that was originally discovered on the basis of homology to Yak1, an inhibitor of cell cycle progression in yeast. At present, mDYRK-3 and mDYRK-2 have been cloned, and mDYRK-3 has been characterized with respect to kinase activity, expression among tissues and hematopoietic cells, and possible function during erythropoiesis. In sequence, mDYRK-3 diverges markedly in noncatalytic domains from mDYRK-2 and mDYRK-1a, but is 91.3% identical overall to hDYRK-3. Catalytically, mDYRK-3 readily phosphorylated myelin basic protein (but not histone 2B) and also appeared to autophosphorylate in vitro. Expression of mDYRK-1a, mDYRK-2, and mDYRK-3 was high in testes, but unlike mDYRK1a and mDYRK 2, mDYRK-3 was not expressed at appreciable levels in other tissues examined. Among hematopoietic cells, however, mDYRK-3 expression was selectively elevated in erythroid cell lines and primary pro-erythroid cells. In developmentally synchronized erythroid progenitor cells, expression peaked sharply following exposure to erythropoietin plus stem cell factor (SCF) (but not SCF alone), and in situ hybridizations of sectioned embryos revealed selective expression of mDYRK-3 in fetal liver. Interestingly, antisense oligonucleotides to mDYRK-3 were shown to significantly and specifically enhance colony-forming unit–erythroid colony formation. Thus, it is proposed that mDYRK-3 kinase functions as a lineage-restricted, stage-specific suppressor of red cell development.
Macrophage inflammatory protein-1α uses a novel receptor for primitive hemopoietic cell inhibition
Authors: Ottersbach Katrin , Cook Donald N. , Kuziel William A. , Humbles Alison , Lu Bao , Gerard Craig , Proudfoot Amanda E. I. , Graham Gerard J. 
Published: July 2002

AbstractMacrophage inflammatory protein-1α (MIP-1α) is a member of the chemokine family of proinflammatory mediators. In addition to its inflammatory roles, MIP-1α has been shown to be active as an inhibitor of primitive hemopoietic cell proliferation. Indeed, a dysfunction in this inhibitory process has been postulated to contribute to leukemogenesis. Research has been aimed at characterizing the receptor involved in cellular inhibition by MIP-1α. This study demonstrates that of all the β-chemokines tested, only MIP-1α is capable of inhibiting primitive hemopoietic cell proliferation. Because no MIP-1α–specific receptors have been identified, this suggests that inhibition is mediated by an uncharacterized receptor. Further evidence for the involvement of a novel receptor in this process is the equivalent potencies of MIP-1αS and MIP-1αP variants of human MIP-1α and the fact that primitive cells from bone marrow derived from individual MIP-1α receptor null mice display a full response to MIP-1α inhibition.
Social Risk Factor Domains and Preventive Care Services in US Adults
Authors: Schroeder Tamara , Ozieh Mukoso N. , Thorgerson Abigail , Williams Joni S. , Walker Rebekah J. , Egede Leonard E. 
Published: October 2024

ImportanceGrowing evidence suggests that social determinants of health are associated with low uptake of preventive care services.ObjectiveTo examine the independent associations of social risk factor domains with preventive care services among US adults.Design, Setting, and ParticipantsThis cross-sectional study used National Health Interview Survey data on 82 432 unweighted individuals (239 055 950 weighted) from 2016 to 2018. Subpopulations were created for each of the primary outcomes: routine mammography (women aged 40-74 years), Papanicolaou test (women aged 21-65 years), colonoscopy (adults aged 45-75 years), influenza vaccine (adults aged ≥18 years), and pneumococcal vaccine (adults aged ≥65 years). Statistical analysis was performed from July to December 2023.ExposuresSix social risk domains (economic instability, lack of community, education deficit, food insecurity, social isolation, and lack of access to care) and a count of domains.Main Outcomes and MeasuresLogistic regression models were used to examine the independent association between each primary outcome (mammography, Papanicolaou test, colonoscopy, influenza vaccine, and pneumococcal vaccine) and social risk factor domains, while controlling for covariates (age, sex, race and ethnicity, health insurance, and comorbidities).ResultsA total of 82 432 unweighted US individuals (239 055 950 weighted individuals) were analyzed. A total of 54.3% were younger than 50 years, and 51.7% were female. All 5 screening outcomes were associated with educational deficit (mammography: odds ratio [OR], 0.73 [95% CI, 0.67-0.80]; Papanicolaou test: OR, 0.78 [95% CI, 0.72-0.85]; influenza vaccine: OR, 0.71 [95% CI, 0.67-0.74]; pneumococcal vaccine: OR, 0.68 [95% CI, 0.63-0.75]; colonoscopy: OR, 0.82 [95% CI, 0.77-0.87]) and a lack of access to care (mammography: OR, 0.32 [95% CI, 0.27-0.38]; Papanicolaou test: OR, 0.49 [95% CI, 0.44-0.54]; influenza vaccine: OR, 0.44 [95% CI, 0.41-0.47]; pneumococcal vaccine: OR, 0.30 [95% CI, 0.25-0.38]; colonoscopy: OR, 0.35 [95% CI, 0.30-0.41]). Fully adjusted models showed that every unit increase in social risk count was significantly associated with decreased odds of receiving a mammography (OR, 0.74 [95% CI, 0.71-0.77]), Papanicolaou test (OR, 0.84 [95% CI, 0.81-0.87]), influenza vaccine (OR, 0.81 [95% CI, 0.80-0.83]), pneumococcal vaccine (OR, 0.80 [95% CI, 0.77-0.83]), and colonoscopy (OR, 0.88 [95% CI, 0.86-0.90]).Conclusions and RelevanceThis cross-sectional study of US adults suggests that social risk factor domains were associated with decreased odds of receiving preventive services; this association was cumulative. There is a need to address social risk factors to optimize receipt of recommended preventive services.
Remote sensing reveals the importance of seminatural habitat and irrigation on aphid biocontrol in arid agroecosystems
Authors: Call Anson , Akiba Sami , Pringle Elizabeth G. 
Published: October 2024

Abstract

Remote sensing and spatial analyses are increasingly used to understand the role of seminatural habitats in biocontrol, but knowing how to best leverage these tools is a persistent challenge. In arid agroecosystems, irrigation often exaggerates the differences between crop fields and their interspaces. Weeds adjacent to irrigated fields are thus often some of the only persistent vegetation. Remote sensing may be essential to capture the effect of this fine‐scale variation on pest biocontrol.

We examined the role of land‐cover in determining the degree of aphid pest pressure and biocontrol in irrigated alfalfa fields in the Great Basin Desert (Nevada, USA). We experimentally manipulated predator densities to determine true agents of aphid biocontrol in this system. We then assessed land‐cover and spatial scale using alternative methods to determine the approaches that best defined the combined direct and indirect effects of seminatural habitat on aphid pest suppression.

A remote‐sensing approach revealed the importance of land‐cover to aphid biocontrol more clearly than conventional vegetation surveys. In particular, remote sensing revealed that weedy patches within alfalfa fields reduced aphid densities, whereas flood irrigation increased aphid densities.

Our experiments confirmed that coccinellid beetles are important aphid biocontrol agents. Coccinellids were positively associated with weedy land‐cover that was spatially close to alfalfa fields, particularly in the spring. Other predator taxa were also associated with distinct landscape features, though these associations varied between spring and fall.

Solution: Weedy seminatural habitat near alfalfa fields, occurring along field margins and the banks of irrigation ditches, was positively associated with the density of coccinellid beetles and associated aphid pest suppression. Remote sensing excelled at identifying these areas and their effects, highlighting its utility as a management tool. Preserving these weedy areas can enhance aphid biocontrol, but farmers must consider potential trade‐offs between the control of insect‐pests and weeds.
Bioinspired Stretchable Strain Sensor with High Linearity and Superhydrophobicity for Underwater Applications
Authors: Wu Huansheng , Wang Cong , Liu Linpeng , Liu Zhilin , He Jiahua , Zhang Changchao , Duan Ji‐an 
Published: October 2024

AbstractFlexible strain sensors are of great significance in health monitoring, wearable electronic devices, intelligent robot sensing, and other fields. Most of the reported works focus on the enhancement of sensitivity or working range, while linearity is ignored and exhibits strong nonlinearity. Conflict among performances remains a serious challenge for the development of flexible strain sensors. Herein, inspired by the architecture of butterfly's wings, a strain sensor with double conductive layers and wrinkles/holes structures is proposed. The fabricated sensor shows a high linearity of >0.98 over a full working strain range of 120%, and a linearity of up to 0.999 within a strain range of 0%–30%. Apart from that, the sensor also presents a sensitivity of 8.28, high stability over 40 000 cycles when subjected to a full‐scale strain, as well as a water contact angle of >167.4°. Meanwhile, strains as low as 0.075% can be identified, while a maximum frequency of 40 Hz can be responded to for the sensor. It is demonstrated that the sensor is capable of enabling flexible grippers to sense and monitor the motions of underwater vehicles, indicating its greater potential for diverse applications, such as human–machine interaction, marine environmental protection, and biological research.
Targeted Therapy of Osteoarthritis via Intra‐Articular Delivery of Lipid‐Nanoparticle‐Encapsulated Recombinant Human FGF18 mRNA
Authors: Sun Mengze , Ma Bin , Pan Zihang , Zhao Yun , Tian Liangliang , Fan Yifei , Kong Weijing , Wang Junyan , Xu Boyang , Ao Yingfang , Guo Quanyi , Wang Xi , Peng Xiaohong , Li Xiaoxia , Cheng Jin , Miao Lei , Wang Kai , Hu Xiaoqing 
Published: October 2024

AbstractFibroblast growth factor 18 (FGF18) emerges as a promising therapeutic target for osteoarthritis (OA). In this study, a novel articular cavity‐localized lipid nanoparticle (LNP) named WG‐PL14 is developed. This optimized formulation has a nearly 30‐fold increase in mRNA expression as well as better articular cavity enrichment compared to commercial lipids MC3 when performing intra‐articular injection. Then, a mRNA sequence encoding recombinant human FGF18 (rhFGF18) for potential mRNA therapy in OA is optimized. In vitro assays confirm the translation of rhFGF18 mRNA into functional proteins within rat and human chondrocytes, promoting cell proliferation and extracellular matrix (ECM) synthesis. Subsequently, the therapeutic efficacy of the LNP‐rhFGF18 mRNA complex is systematically assessed in a mouse OA model. The administration exhibits several positive outcomes, including an improved pain response, upregulation of ECM‐related genes (e.g., AGRN and HAS2), and remodeling of subchondral bone homeostasis compared to a control group. Taken together, these findings underscore the potential of localized LNP‐rhFGF18 mRNA therapy in promoting the regeneration of cartilage tissue and mitigating the progression of OA.
Flexible Soft X‐Ray Image Sensors based on Metal Halide Perovskites With High Quantum Efficiency
Authors: Tan Pengju , Liu Tianyu , Yang Yuqian , Chen Yuangan , Guan Yong , Li Zidu , Yu Shunjie , Yang Xunyong , Xiang Xueqiang , Zhao Xiaolong , Li Yu , Ding Honghe , Wu Xuefei , Fink Zachary , Gao Shuang , Hou Xiaohu , Jiao Xuechen , Zhu Junfa , Fan Fengjia , Yang Shangfeng , Russell Thomas P. , Liu Xiaosong , Hu Qin , Long Shibing 
Published: October 2024

AbstractSoft X‐ray imaging is a powerful tool to explore the structure of cells, probe material with nanometer resolution, and investigate the energetic phenomena in the universe. Conventional soft X‐ray image sensors are by and large Si‐based charge coupled devices that suffer from low frame rates, complex fabrication processes, mechanical inflexibility, and required cooling below −60 °C. Here, a soft X‐ray photodiode is reported based on low‐cost metal halide perovskite with comparable performance to commercial Si‐based device. Nanothrough network electrode minimized the optical loss due to the shadowing of insensitive layers, while a multidimensional perovskite heterojunction is generated to reduce the photo‐generated carrier loss. This strategy promoted a record quantum efficiency of 8 × 103% without cooling, several orders of magnitude greater than the previously achieved. Flexible and curved soft X‐ray imaging arrays are fabricated based on this high‐performance device structure, demonstrating stable soft X‐ray response and sharp imaging capabilities. This work highlights the low‐cost and efficient perovskite photodiode as a strong candidate for the next‐generation soft X‐ray image sensors.
NHC‐Catalyzed Synthesis of 2‐Aroylchromones and Their Application in the Synthesis of Wrightiadione Analogues
Authors: Koyama Futa , Lamb Justin S. , Hirao Moena , Suzuki Noriyuki , Yoshizawa‐Fujita Masahiro , Usuki Toyonobu , Suzuki Yumiko 
Published: October 2024

AbstractWith a number of biologically active members, 2‐aroylchromones are valuable synthetic targets. A direct route towards 2‐aroylchromones from 2‐(methylsulfonyl)chromones and aldehydes via NHC‐catalyzed C−C bond formation was developed. Yields of the synthesized 2‐aroylchromones were up to 85%. Chromones with angioprotective or antibacterial properties were easily synthesized using the method developed. Additionally, the synthetic utility of the afforded chromones was demonstrated by using them to synthesize the anticancer compound wrightiadione and analogues of it.
Photocatalytic Silylation of Aryl Alkynoates: Synthesis of Silylated Coumarins
Authors: Ladumor Ravikumar , Samanta Sourav , Selvakumar Sermadurai 
Published: October 2024

AbstractHerein, we report the photocatalytic synthesis of 3‐silyl coumarins using hydrosilanes as the silyl radical source with aryl alkynoates. Readily prepared N‐aminopyridinium salts act as hydrogen atom transfer reagents for generating silyl radicals under photoredox catalysis. The reaction proceeds through a silyl radical addition to alkyne followed by radical cascade cyclization/migration with subsequent oxidation and aromatization to give the desired 3‐silyl coumarins in 34–89% yield.
Genome‐Wide Profiling of H3K27ac Identifies TDO2 as a Pivotal Therapeutic Target in Metabolic Associated Steatohepatitis Liver Disease
Authors: Zhu Yaling , Shang Limeng , Tang Yunshu , Li Qiushuang , Ding Lin , Wang Yi , Zhang Tiantian , Xie Bin , Ma Jinhu , Li Xinyu , Chen Shuwen , Yi Xinrui , Peng Jin , Liang Youfeng , He Anyuan , Yan Hong , Zhu Huaqing , Zhang Buchun , Zhu Yong 
Published: October 2024

AbstractH3K27ac has been widely recognized as a representative epigenetic marker of active enhancer, while its regulatory mechanisms in pathogenesis of metabolic dysfunction‐associated steatotic liver disease (MASLD) remain elusive. Here, a genome‐wide comparative study on H3K27ac activities and transcriptome profiling in high fat diet (HFD)‐induced MASLD model is performed. A significantly enhanced H3K27ac density with abundant alterations of regulatory transcriptome is observed in MASLD rats. Based on integrative analysis of ChIP‐Seq and RNA‐Seq, TDO2 is identified as a critical contributor for abnormal lipid accumulation, transcriptionally activated by YY1‐promoted H3K27ac. Furthermore, TDO2 depletion effectively protects against hepatic steatosis. In terms of mechanisms, TDO2 activates NF‐κB pathway to promote macrophages M1 polarization, representing a crucial event in MASLD progression. A bovine serum albumin nanoparticle is fabricated to provide sustained release of Allopurinol (NPs‐Allo) for TDO2 inhibition, possessing excellent biocompatibility and desired targeting capacity. Venous injection of NPs‐Allo robustly alleviates HFD‐induced metabolic disorders. This study reveals the pivotal role of TDO2 and its underlying mechanisms in pathogenesis of MASLD epigenetically and genetically. Targeting H3K27ac‐TDO2‐NF‐κB axis may provide new insights into the pathogenesis of abnormal lipid accumulation and pave the way for developing novel strategies for MASLD prevention and treatment.
The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation
Authors: Li Chenxi , Liu Qiongliang , Han Lianyong , Zhang Haiyun , Immler Roland , Rathkolb Birgit , Secklehner Judith , de Angelis Martin Hrabe , Yildirim Ali Önder , Zeuschner Dagmar , Nicke Annette , Carlin Leo M. , Sperandio Markus , Stoeger Tobias , Rehberg Markus 
Published: October 2024

AbstractExposure to nanoparticles (NPs) is frequently associated with adverse cardiovascular effects. In contrast, NPs in nanomedicine hold great promise for precise lung‐specific drug delivery, especially considering the extensive pulmonary capillary network that facilitates interactions with bloodstream‐suspended particles. Therefore, exact knowledge about effects of engineered NPs within the pulmonary microcirculation are instrumental for future application of this technology in patients. To unravel the real‐time dynamics of intravenously delivered NPs and their effects in the pulmonary microvasculature, we employed intravital microscopy of the mouse lung. Only PEG‐amine‐QDs, but not carboxyl‐QDs triggered rapid neutrophil recruitment in microvessels and their subsequent recruitment to the alveolar space and was linked to cellular degranulation, TNF‐α, and DAMP release into the circulation, particularly eATP. Stimulation of the ATP‐gated receptor P2X7R induced expression of E‐selectin on microvascular endothelium thereby mediating the neutrophilic immune response. Leukocyte integrins LFA‐1 and MAC‐1 facilitated adhesion and decelerated neutrophil crawling on the vascular surface. In summary, this study unravels the complex cascade of neutrophil recruitment during NP‐induced sterile inflammation. Thereby we demonstrate novel adverse effects for NPs in the pulmonary microcirculation and provide critical insights for optimizing NP‐based drug delivery and therapeutic intervention strategies, to ensure their efficacy and safety in clinical applications.
Temperature‐Dependent Dynamics of Charge Carriers in Tellurium Hyperdoped Silicon
Authors: Rahman KM Ashikur , Shaikh Mohd Saif , Yue Qianao , Dissanayake S. Senali , Wang Mao , Zhou Shengqiang , Sher Meng‐Ju 
Published: October 2024

AbstractTellurium‐hyperdoped silicon (Si:Te) shows significant promise as an intermediate band material candidate for highly efficient solar cells and photodetectors. Time‐resolved THz spectroscopy (TRTS) is used to study the excited carrier dynamics of Si hyperdoped with 0.5, 1, and 2%. The two photoexcitation wavelengths enable us to understand the temperature‐dependent carrier transport in the hyperdoped region in comparison with the Si region. Temperature significantly influences the magnitude of transient conductivity and decay time when photoexcited by light with a wavelength of 400 nm. Due to the differential mobilities in the Si and hyperdoped regions, such dependence is absent under 266‐nm excitation. Consistent with the literature, the charge‐carrier lifetime decreases with increasing dopant concentration. It is found that the photoconductivity becomes less temperature‐dependent as the dopant concentration increases. In the literature, the photodetection range of Si:Te extends to a wavelength of 5.0 µm at a temperature of 20 K. The simulation shows that carrier diffusion, driven by concentration gradients, is strongly temperature dependent and impacts transient photoconductivity decay curves. The simulation also revealed that, in the hyperdoped regions, the carrier recombination rate remains independent of temperature.