bluuebunny/crossref_metadata_2025_split huggingface dataset:
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors
Authors: Brænne Ingrid , Willenborg Christina , Tragante Vinicius , Kessler Thorsten , Zeng Lingyao , Reiz Benedikt , Kleinecke Mariana , von Ameln Simon , Willer Cristen J. , Laakso Markku , Wild Philipp S. , Zeller Tanja , Wallentin Lars , Franks Paul W. , Salomaa Veikko , Dehghan Abbas , Meitinger Thomas , Samani Nilesh J. , Asselbergs Folkert W. , Erdmann Jeanette , Schunkert Heribert 
Published: August 2017

AbstractCyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narrow potential mechanisms affecting CAD risk as we hypothesized that the affected genes may also display genomic signals of coronary disease risk. A Drug Gene Interaction Database search identified 47 gene products to be affected by coxibs. We traced association signals in 200-kb regions surrounding these genes in 84,813 CAD cases and 202,543 controls. Based on a threshold of 1 × 10−5 (Bonferroni correction for 3131 haplotype blocks), four gene loci yielded significant associations. The lead SNPs were rs7270354 (MMP9), rs4888383 (BCAR1), rs6905288 (VEGFA1), and rs556321 (CACNA1E). By additional genotyping, rs7270354 at MMP9 and rs4888383 at BCAR1 also reached the established GWAS threshold for genome-wide significance. The findings demonstrate overlap of genes affected by coxibs and those mediating CAD risk and points to further mechanisms, which are potentially responsible for coxib-associated CAD risk. The novel approach furthermore suggests that genetic studies may be useful to explore the clinical relevance of off-target drug effects.
Rising tides, cumulative impacts and cascading changes to estuarine ecosystem functions
Authors: O’Meara Theresa A. , Hillman Jenny R. , Thrush Simon F. 
Published: August 2017

AbstractIn coastal ecosystems, climate change affects multiple environmental factors, yet most predictive models are based on simple cause-and-effect relationships. Multiple stressor scenarios are difficult to predict because they can create a ripple effect through networked ecosystem functions. Estuarine ecosystem function relies on an interconnected network of physical and biological processes. Estuarine habitats play critical roles in service provision and represent global hotspots for organic matter processing, nutrient cycling and primary production. Within these systems, we predicted functional changes in the impacts of land-based stressors, mediated by changing light climate and sediment permeability. Our in-situ field experiment manipulated sea level, nutrient supply, and mud content. We used these stressors to determine how interacting environmental stressors influence ecosystem function and compared results with data collected along elevation gradients to substitute space for time. We show non-linear, multi-stressor effects deconstruct networks governing ecosystem function. Sea level rise altered nutrient processing and impacted broader estuarine services ameliorating nutrient and sediment pollution. Our experiment demonstrates how the relationships between nutrient processing and biological/physical controls degrade with environmental stress. Our results emphasise the importance of moving beyond simple physically-forced relationships to assess consequences of climate change in the context of ecosystem interactions and multiple stressors.
Is there a frontier in sensitivity with Lossy mode resonance (LMR) based refractometers?
Authors: Ozcariz Aritz , Zamarreño Carlos R. , Zubiate Pablo , Arregui Francisco J. 
Published: August 2017

AbstractA tin dioxide thin layer has been studied in order to improve the sensitivity of lossy mode resonances (LMR) based sensors. The effects of the thin film thickness and the polarization of light in a SnO2 coated D-shaped single mode optical fiber have been evaluated. The optimization of such parameters in the fabrication of refractometers have led to an unprecedented sensitivity of over one million nanometers per refractive index unit (RIU), which means a sensitivity below 10−9 RIU with a pm resolution detector. This achievement is a milestone for the development of new high sensitivity devices and opens the door to new industrial applications, such as gear oil degradation, or biomedical devices where previous devices could not provide enough sensitivity.
Influence of Bone Marrow Edema on Medial Unicompartmental Knee Arthroplasty among Patients with Patellofemoral Osteoarthritis
Authors: Yue Jiaji , Ma Xiaojun , Li Yaqiang , Wang Yu , Zhu Yuchang , Cheng Biao , Yang Chunxi 
Published: August 2017

AbstractThis study aims to compare clinical outcomes in unicompartmental knee arthroplasty (UKA) patients with or without magnetic resonance imaging (MRI) evidence of bone marrow edema (BME) in the patella and to evaluate the effect of functional outcomes after UKA in patients with patellofemoral osteoarthritis (PF OA). Outcomes of 146 knees in 141 patients who underwent medial UKA were included. According to their preoperative condition of patellofemoral joints, patients were divided into three groups: Group A, non-PF OA (Kellgren–Lawrence [K–L] scale = 0); group B, PF OA without BME (K–L ≥ 1, bone marrow edema pattern [BMEP] = 0); group C, PF OA with BME (K–L ≥ 1, BMEP ≥ 1). Clinical outcomes including visual analog scale (VAS) scores of knee pain, Hospital for Special Surgery (HSS) scores, and range of motions (ROMs) were evaluated and analyzed at the postoperative follow-up of 3 months and 2 years. From our results, BME was highly correlated to poor outcome in patients with UKA. At follow-up of 3 months, BME influenced the clinical outcome of UKA at an early postoperative stage in terms of VAS scores, HSS scores, and ROMs. At the final follow-up of 2 years, the clinical outcome was improved in terms of HSS score, although the anterior knee pain and active ROMs were still worse than that of patients without BME. In conclusion, there was no significant difference in clinical outcomes in patients without BME regardless of PF OA. However, the condition of BME should be taken serious consideration because of its indication of an adverse effect on the outcome after UKA.
Old Solutions for New Troubles in Complications after Thoracic Endovascular Aortic Repair
Authors: Fortunato German , Stöger Guillermo , Marenchino Ricardo , Kotowicz Vadim 
Published: August 2017

Background The authors present two cases with type B aortic dissection initially treated by endovascular stent graft who developed aortic complications posttreatment and required surgical treatment.
Case Description A 50-year-old woman and a 65-year-old man underwent endovascular treatment for thoracic aortic aneurysm associated with type B dissection and —both of them evolved with endoleak type 1. The first case was related to aortobronchial fistula, and the second one was associated with ascending aortic aneurysm. An extra-anatomical ascending aorta-supraceliac aorta bypass grafting was decided due to the persistent leak.
Conclusion Surgery is an excellent choice for complex complications after thoracic endovascular aortic repair with previous failed attempts of endovascular resolution.
Bilder sagen mehr als Worte
Authors: Harms Marlen 
Published: August 2017

ZusammenfassungDie Diabetesbehandlung ist komplex: Blutzucker messen, Insulin spritzen oder das Vermeiden von Hypoglykämien sind Themen, mit denen die Betroffenen nach ihrer Diagnose das erste Mal in Berührung kommen. Dazu kommt die psychologische Belastung, lebenslang an einer chronischen Erkrankung zu leiden. In dieser Situation müssen nicht unbedingt noch Sprachbarrieren oder eine eingeschränkte kognitive Leistungsfähigkeit hinzukommen, damit Schulungsinhalte rund um die Erkrankung und deren Therapie „nicht ankommen“. Individuelle, ganz auf die persönlichen Bedürfnisse eines Betroffenen abgestimmte Sketchnotes können dann helfen, den Patienten die Grundprinzipien der Diabetesbehandlung nahe zu bringen. Schritt für Schritt wird mit kleinen Zeichnungen erklärt, worauf es beim Blutzuckermessen oder bei der Insulininjektion ankommt. Eine Diabetesschulung können Sketchnotes nicht ersetzten, aber sie können den Einstieg in die Diabetesbehandlung sinnvoll unterstützen.
Die Behandlung der laryngealen Dystonie mit
Botulinumtoxin
Authors: Olthoff Arno , Grosheva Maria , Reichel Gerhard , Volk Gerd Fabian , Laskawi Rainer 
Published: August 2017

ZusammenfassungDie Behandlung der laryngealen Dystonie mit Botulinumtoxin ist erfolgreich und
wird von den Kostenträgern übernommen. Eine qualitativ gute Behandlung sollte
jedem Patienten garantiert werden und deshalb ist es wichtig, generelle
Standards im Expertenkreis zu erstellen. In dem hier vorliegenden Artikel werden
verschiedene Aspekte des Krankheitsbildes „Spasmodische Dysphonie“ bzw.
„Laryngeale Dystonie“ von Experten beleuchtet und diskutiert. Hierzu zählen
neuere Erkenntnisse über die Ätiologie, anatomische Besonderheiten, Standards in
der Diagnostik und der Therapie sowie auch Punkte, die noch in der Diskussion
sind.
Sport für das diabetische Gehirn
Authors: Brinkmann Christian 
Published: August 2017

ZusammenfassungIm Rahmen der Projektförderung „Wii are sporting! – Integrative Studie zur Erforschung der Wirksamkeit von Exergaming auf den Glukosestoffwechsel sowie die körperliche und kognitive Leistungsfähigkeit bei älteren Typ-2-Diabetikern“ durch die Deutsche Diabetes Stiftung (DDS) wurde der Einfluss einer Akutbelastung auf neurotrophe Faktoren untersucht, die unter anderem zur Bildung neuer Nervenzellen im Gehirn beitragen können – mit überraschenden Ergebnissen.
Ambulante Versorgung von Geflüchteten durch Tropenmediziner
Authors: Höcker Jenny , Fischer Florian , Krämer Alexander , Prüfer-Krämer Luise 
Published: August 2017

ZusammenfassungNiedergelassene Tropenmediziner beteiligen sich im Praxisalltag unter anderem mit der medizinischen Versorgung von Geflüchteten. Um die Chancen und Herausforderungen dieser Tätigkeit aufzuarbeiten, wurden 8 leidfadengestützte qualitative Experteninterviews im Zeitraum von Januar bis März 2016 mit niedergelassenen Tropenmedizinern geführt. Es zeigte sich, dass die Geflüchteten vornehmlich hausärztlich zu behandelnde Erkrankungen (z.B. Infektionen des oberen Respirationstrakts oder Magen- und Darminfekte) aufweisen, es kommen jedoch auch seltene Infektionen und Tropenkrankheiten vor. Schwierigkeiten stellen vor allem sprachliche und kulturelle Barrieren dar. Die Einführung der elektronischen Gesundheitskarte wird als wünschenswert angesehen, um bürokratische Hürden zu verringern. Wichtig ist zudem die Förderung einer engeren Zusammenarbeit zwischen Tropenmedizinern und Hausärzten.
Quantitative tests of a reconstitution model for RNA folding thermodynamics and kinetics
Authors: Bisaria Namita , Greenfeld Max , Limouse Charles , Mabuchi Hideo , Herschlag Daniel 
Published: August 2017

Significance
We propose and test predictions of a thermodynamic and kinetic model for RNA tertiary folding that is based on separable energetic contributions of RNA elements. We define these contributions based on the principle features of RNA, and we test the basic predictions of separability by determining whether the energetic contributions of one component are affected by changes in another component. Our results support energetic separability of RNA elements and suggest that it may be possible to deconstruct RNAs into smaller parts that can be studied in isolation such that the individual folding behaviors of these parts can be used to “reconstitute” the folding of the original RNA.
Purifying a Yellowstone Cutthroat Trout Stream by Removing Rainbow Trout and Hybrids via Electrofishing
Authors: Meyer Kevin A. , Kennedy Patrick , High Brett , Campbell Matthew R. 
Published: August 2017

AbstractThe South Fork of the Snake River in Idaho supports one of the few remaining fluvial populations of Yellowstone Cutthroat Trout Oncorhynchus clarkii bouvieri, but long‐term persistence of Cutthroat Trout in the drainage is threatened by introgression with introduced Rainbow Trout O. mykiss. We completed eight backpack electrofishing removals from 2010 to 2015 to remove Rainbow Trout and Rainbow Trout × Cutthroat Trout hybrids from a 9.3‐km isolated reach of Palisades Creek (a tributary of the South Fork) in an attempt to improve the purity of the population. For two removals, fish from a subsample of Oncorhynchus were genetically screened at seven diagnostic nuclear DNA loci. A total of 14,092 fish were captured across all removals, of which 3,446 were putative Rainbow Trout or hybrids, which were removed from the stream. The proportion of the total catch that Yellowstone Cutthroat Trout comprised (across all size‐classes combined) increased slowly over time, from 67% in 2010 to 86% for the second removal in 2015. By the end of the study, an estimated 90% of the alleles at the loci we screened were Cutthroat Trout compared with 80% at the beginning. Capture efficiency across all years and size‐classes averaged 38%, ranged from 23% to 52%, and was much higher for larger fish (i.e., ≥250 mm TL) than for smaller fish. Considering the capture efficiencies achieved, initial hybridization levels observed, and number of removals conducted, ending phenotypic purity should have been 94% rather than the 86% we observed. This discrepancy was at least partly due to low capture efficiency for fish < 150 mm and extremely high flows throughout 2011 that prevented electrofishing removals that year, but also suggests that Rainbow Trout and hybrids somehow might have been recolonizing the stream or had a competitive or survival advantage over Cutthroat Trout.
Bi-lateral comparison APMP.L-K5.2006.1—calibration of step gauge
Authors: Abe Makoto , Drijarkara A Praba , Babu Virendra 
Published: August 2017

This report concerns an international bilateral key comparison involving two laboratories using three facilities in the subject of calibration of step gauges, which are artefacts used for performance verification of coordinate measuring machines. A third laboratory was selected as an independent adjudicator. The comparison ran from August 2012 to May 2013 during which time there was no significant deterioration in the circulated artefact but the pilot laboratory observed slight change of about 0.15 μm in the measurement result between two measurements, at opposite ends of the circulation. The artefact was a step gauge containing 102 nominally parallel planes half facing each direction (forwards, reverse) with the measurands being the distances between a reference plane and the other planes, measured in the centres. Both participants were able to demonstrate their CMC as listed on the KCDB.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
PhyloGeoTool: interactively exploring large phylogenies in an epidemiological context
Authors: Libin Pieter , Vanden Eynden Ewout , Incardona Francesca , Nowé Ann , Bezenchek Antonia ,   EucoHIV Study Group, Sönnerborg Anders , Vandamme Anne-Mieke , Theys Kristof , Baele Guy 
Published: August 2017

Abstract

Motivation
Clinicians, health officials and researchers are interested in the epidemic spread of pathogens in both space and time to support the optimization of intervention measures and public health policies. Large sequence databases of virus sequences provide an interesting opportunity to study this spread through phylogenetic analysis. To infer knowledge from large phylogenetic trees, potentially encompassing tens of thousands of virus strains, an efficient method for data exploration is required. The clades that are visited during this exploration should be annotated with strain characteristics (e.g. transmission risk group, tropism, drug resistance profile) and their geographic context.

Results
PhyloGeoTool implements a visual method to explore large phylogenetic trees and to depict characteristics of strains and clades, including their geographic context, in an interactive way. PhyloGeoTool also provides the possibility to position new virus strains relative to the existing phylogenetic tree, allowing users to gain insight in the placement of such new strains without the need to perform a de novo reconstruction of the phylogeny.

Availability and implementation
https://github.com/rega-cev/phylogeotool (Freely available: open source software project).

Supplementary information
Supplementary data are available at Bioinformatics online.
Morphometric discrimination of pelagic fish stocks challenged by variation in body condition
Authors: Geladakis George , Nikolioudakis Nikolaos , Koumoundouros George , Somarakis Stylianos 
Published: August 2017

Abstract
Morphometric characters have traditionally been used to describe the population structure of fishes. Body shape variation, which is often environmentally induced, may provide a good record of short-term population structuring. However, factors unrelated to environmental or genetic influences on body morphology may complicate sampling and the use of morphometric features for stock discrimination. In the present study, we used geometric morphometric variables to compare the European sardine Sardina pilchardus putative stocks of the Aegean and Ionian Seas (eastern Mediterranean). Landmark data of fish collected at seven different sites were subjected to canonical analysis of principal coordinates (CAP). The average body condition of sardines from these sites was strongly and linearly related to corresponding scores along CAP1, the axis exhibiting the highest correlation with the morphometric data cloud. The average scores along CAP2 and CAP3 appeared to be linked to morphological differentiation related to temperature effects and prey availability (mesozooplankton biomass). Despite the primary and confounding effect of body condition, discrimination of different morphotypes corresponding to the Aegean and the Ionian Sea stocks was highly significant with 81% correct reallocations for the respective CAP model.
Excess Volatility: Beyond Discount Rates*
Authors: Giglio Stefano , Kelly Bryan 
Published: August 2017

Abstract
We document a form of excess volatility that is difficult to reconcile with standard models of prices, even after accounting for variation in discount rates. We compare prices of claims on the same cash flow stream but with different maturities. Standard models impose precise internal consistency conditions on the joint behavior of long- and short-maturity claims and these are strongly rejected in the data. In particular, long-maturity prices are significantly more variable than justified by the behavior at short maturities. We reject internal consistency conditions in all term structures that we study, including equity options, currency options, credit default swaps, commodity futures, variance swaps, and inflation swaps.
Reducing the celiac disease antigenicity of wheat
Authors: Malalgoda Maneka , Manthey Frank , Simsek Senay 
Published: August 2017

Background and objectivesCeliac disease (CD) affects nearly one in 110 people in the United States, and it is caused by specific prolamin proteins found in cereals such as wheat, rye, and barley. Currently, the only medical solution for celiac patients is a gluten‐free diet. However, there is growing interest in breeding for wheat, barley, and rye cultivars that are safe for patients with CD. In this context, the objective of this review was to examine approaches that could be used to reduce the celiac antigenicity of wheat.FindingsTechniques such as utilizing genetic variations among cultivars, genome editing techniques, and enzymatic treatments are currently being studied as methods that could be used to produce celiac‐safe wheat. One challenge in producing such cultivars is preserving the viscoelastic properties of dough, as prolamin proteins have a vital role in the formation and viscoelasticity of dough.ConclusionsThis review shows that there is promise in developing celiac‐safe wheat using a combination of techniques; however, addressing the issue of preserving the rheological properties of wheat while reducing the antigenicity still needs to be addressed.Significance and noveltyProducing celiac‐safe wheat while conserving the viscoelastic properties of wheat maybe possible, using a combination of methods such as cultivar selection, genome editing, and enzymatic modifications.
The Role of Carbetocin in the Prevention and Management of Postpartum Haemorrhage
Authors: Meshykhi L.S. , Nel M.R. , Lucas D.N. 
Published: August 2017

(Int J Obstet Anesth. 2016;28:61–69)
One of the serious obstetric complications and a leading cause of maternal morbidity and mortality is postpartum hemorrhage (PPH), the incidence of which has been increasing in many countries. The most common cause of PPH is uterine atony, and evidence supports the pharmacologic management of the third stage of labor with a uterotonic to decrease the risk of PPH.
Incidence and Severity of Chronic Pain After Caesarean Section: A Systematic Review With Meta-Analysis
Authors: Weibel S. , Neubert K. , Jelting Y. , Meissner W. , Wöckel A. , Roewer N. , Kranke P. 
Published: August 2017

(Eur J Anaesthesiol. 2016;33(11):853–865)
Cesarean section (CS) rates have increased throughout the developed world over the past several decades. Currently, nearly one third of deliveries in the United States and one quarter in Europe occur via CS. Thus, CS is one of the most common surgeries performed throughout the world, amounting to 22.9 million cases in 2012. Chronic postsurgical pain (CPSP) has been identified as a significant problem after many surgical procedures but the data are somewhat limited and inconsistent for CS. These authors conducted a systematic review and meta-analysis to analyze CPSP among women after CS. The objective of this research was to determine the incidence and severity of CPSP following CS.
Does Tranexamic Acid Prevent Postpartum Haemorrhage? A Systematic Review of Randomized Controlled Trials
Authors: Ker K. , Shakur H. , Roberts I. 
Published: August 2017

(BJOG. 2016;123(11):1745–1752)
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide. When PPH becomes life-threatening it sometimes requires hysterectomy, which deprives women of their ability to bear children in the future. Tranexamic acid (TXA) has been used successfully in trauma patients to control bleeding by inhibiting the breakdown of fibrin clots. Its use for obstetric hemorrhage is currently being evaluated. The authors performed a systematic review of randomized controlled trials to assess the efficacy of TXA to prevent postpartum hemorrhage as well as its effect on other clinically important outcomes.
Peripartum Cardiomyopathy: A Systematic Literature Review
Authors: Ersbøll A.S. , Damm P. , Gustafsson F. , Vejlstrup N.G. , Johansen M. 
Published: August 2017

(Acta Obstet Gynecol Scand. 2016;95(11):1205–1219)
Peripartum cardiomyopathy (PPCM) is a rare cause of heart failure in pregnant women worldwide. However, the incidence in the United States has risen from 1:4350 live births in 1990 to 1993 to 1:968 in 2003 to 2011. This recent rise in cases may be explained by increased awareness of the condition as well as increases in maternal age, multiple gestation, chronic hypertension, and use of assisted reproductive technology. Although viral infection, selenium deficiency, autoimmunity and genetic factors have been suggested as contributing factors in PPCM, Fms-like tyrosine kinase 1 (sFlt-1) and the hormone prolactin have been the subject of recent research. PPCM can be difficult to diagnose because symptoms resemble those of other pregnancy-related conditions. This review aimed to supply clinicians with current information on the diagnosis, mechanisms and management of PPCM.