bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes
Authors: Hill Thomas G. , Gao Rui , Benrick Anna , Kothegala Lakshmi , Rorsman Nils , Santos Cristiano , Acreman Samuel , Briant Linford J. , Dou Haiqiang , Gandasi Nikhil R. , Guida Claudia , Haythorne Elizabeth , Wallace Marsha , Knudsen Jakob G. , Miranda Caroline , Tolö Johan , Clark Anne , Davison Lucy , Størling Joachim , Tarasov Andrei , Ashcroft Frances M. , Rorsman Patrik , Zhang Quan 
Published: September 2024

AbstractDiabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion1. In healthy people, a fall in plasma glucose stimulates glucagon release and thereby increases counter-regulatory hepatic glucose production. This response is absent in many patients with type-1 diabetes (T1D)2, which predisposes to severe hypoglycaemia that may be fatal and accounts for up to 10% of the mortality in patients with T1D3. In rats with chemically induced or autoimmune diabetes, counter-regulatory glucagon secretion can be restored by SSTR antagonists4–7 but both the underlying cellular mechanism and whether it can be extended to humans remain unestablished. Here, we show that glucagon secretion is not stimulated by low glucose in isolated human islets from donors with T1D, a defect recapitulated in non-obese diabetic mice with T1D. This occurs because of hypersecretion of somatostatin, leading to aberrant paracrine inhibition of glucagon secretion. Normally, KATP channel-dependent hyperpolarization of β-cells at low glucose extends into the δ-cells through gap junctions, culminating in suppression of action potential firing and inhibition of somatostatin secretion. This ‘electric brake’ is lost following autoimmune destruction of the β-cells, resulting in impaired counter-regulation. This scenario accounts for the clinical observation that residual β-cell function correlates with reduced hypoglycaemia risk8.
Acoustically semitransparent nanofibrous meshes appraised by high signal-to-noise-ratio MEMS microphones
Authors: Wasisto Hutomo Suryo , Anzinger Sebastian , Acanfora Giovanni , Farrel Aloysius , Sabatini Valentina , Grimoldi Elisa , Marelli Vasco , Ovsiannikov Nikita , Tkachuk Konstantin , Tosolini Giordano , Lucignano Carmine , Mietta Marco , Zhang Guangzhao , Fueldner Marc , Peiner Erwin 
Published: September 2024

AbstractMicroelectromechanical system-based microphones demand high ingress protection levels with regard to their use in harsh environment. Here, we develop environmental protective components comprising polyimide nanofibers combined onto polyether ether ketone fabric meshes and subsequently appraise their impact on the electroacoustic properties of high signal-to-noise-ratio microelectromechanical system-based microphones via industry-standard characterizations and theoretical simulations. Being placed directly on top of the microphone sound port, the nanofiber mesh die-cut parts with an inner diameter of 1.4 mm result in signal-to-noise-ratio and insertion losses of (2.05 ± 0.16) dB(A) and (0.30 ± 0.11) dBFS, respectively, in electroacoustic measurements. Hence, a high signal-to-noise-ratio value of (70.05 ± 0.17) dB(A) can be maintained by the mesh-protected microphone system. Due to their high temperature stability, acoustic performance, environmental robustness, and industry-scale batch production, these nanofibrous meshes reveal high potential to be practically implemented in high-market-volume applications of packaged microelectromechanical system-based microphones.
Rethinking sustainability of marine fisheries for a fast-changing planet
Authors: Roberts Callum , Béné Christophe , Bennett Nathan , Boon James S. , Cheung William W. L. , Cury Philippe , Defeo Omar , De Jong Cleyndert Georgia , Froese Rainer , Gascuel Didier , Golden Christopher D. , Hawkins Julie , Hobday Alistair J. , Jacquet Jennifer , Kemp Paul , Lam Mimi E. , Le Manach Frédéric , Meeuwig Jessica J. , Micheli Fiorenza , Morato Telmo , Norris Catrin , Nouvian Claire , Pauly Daniel , Pikitch Ellen , Amargos Fabian Piña , Saenz-Arroyo Andrea , Sumaila U. Rashid , Teh Louise , Watling Les , O’Leary Bethan C. 
Published: September 2024

AbstractMany seafood products marketed as “sustainable” are not. More exacting sustainability standards are needed to respond to a fast-changing world and support United Nations SDGs. Future fisheries must operate on principles that minimise impacts on marine life, adapt to climate change and allow regeneration of depleted biodiversity, while supporting and enhancing the health, wellbeing and resilience of people and communities. We set out 11 actions to achieve these goals.
MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer
Authors: Bharti Arora , Ajinkya Kulkarni , Andrea Markus M. , Fernanda Ramos-Gomes , Hanibal Bohnenberger , Philipp Ströbel , Frauke Alves , Oliver Klein 
Published: September 2024

AbstractColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, accentuated by its heterogeneity and complex tumour microenvironment (TME). The role of TME on tumour pathophysiology is pivotal, especially the influence of components of the extracellular matrix (ECM), such as collagen. We introduce a novel multimodal imaging strategy to unravel the complex spatial heterogeneity of CRC by integrating the imaging features from two-photon laser scanning microscopy (2PLSM) and histology with proteomics signatures from matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI MSI). Our study is the first to correlate the structural coherence of collagen fibres and the nuclei distribution profile of tumour tissue with the peptide signatures, offering insights into the proteomic landscape of CRC within regions of high nuclei distribution (HND), as well as chaotic and organised regions of collagen. We use this approach to distinguish the patient tissues originating from left-sided colorectal cancer (LSCC) and from right-sided colorectal cancer (RSCC). This discriminative signature highlights the role of high nuclei distribution and collagen architecture in tumour progression. Complementary m/z values of several proteins associated to components of ECM, such as plectin, vinculin, vimentin, and myosin, have shown differentially intensity distributions between LSCC and RSCC. Our findings demonstrate the potential of combining structural information with peptide features to identify molecular signatures in different tumour regions and retrieve new insights into CRC pathophysiology.
The implementation of a cost‐efficient damped AC testing methodology for transmission cables based on DC–AC conversion and distributed partial discharge detection
Authors: Lu Yuxin , Li Hongjie , Zhang Yu , Hu Jing , Yin Lin , He Weisheng , Yan Nianping , Li Tangbing , Zou Jianzhang , Yan Yuan , Zhou Longwu 
Published: September 2024

AbstractThis research introduces a novel damped alternating current (DAC) testing methodology, which integrates an enhanced DAC generator with a pulse‐based distributed partial discharge (PD) detection technique. The advanced DAC generator is designed without the need for high voltage (HV) solid‐state switches, thereby offering a cost‐effective solution for field‐testing voltage generation through a direct current–alternating current conversion approach. To meet the demand for high instantaneous power, a capacitor bank is employed as the power supply. Furthermore, the implementation of a distributed PD detection technique enhances sensitivity and eliminates limitations associated with cable length. To minimize the construction costs of the distributed PD‐detection system, a pulse synchronization technique has been employed. Efforts to reduce the system's weight were informed by simulations, resulting in the design and development of a prototype weighing 850 kg for a 64/110 kV power cable. The reduction in the number of HV solid‐state switches contributes to significant cost savings, amounting to tens of thousands of dollars, when compared to conventional DAC generators. Laboratory and field tests validated the effectiveness of the cost‐efficient DAC testing methodology.
iGATTLDA: Integrative graph attention and transformer‐based model for predicting lncRNA‐Disease associations
Authors: Momanyi Biffon Manyura , Temesgen Sebu Aboma , Wang Tian‐Yu , Gao Hui , Gao Ru , Tang Hua , Tang Li‐Xia 
Published: September 2024

AbstractLong non‐coding RNAs (lncRNAs) have emerged as significant contributors to the regulation of various biological processes, and their dysregulation has been linked to a variety of human disorders. Accurate prediction of potential correlations between lncRNAs and diseases is crucial for advancing disease diagnostics and treatment procedures. The authors introduced a novel computational method, iGATTLDA, for the prediction of lncRNA‐disease associations. The model utilised lncRNA and disease similarity matrices, with known associations represented in an adjacency matrix. A heterogeneous network was constructed, dissecting lncRNAs and diseases as nodes and their associations as edges. The Graph Attention Network (GAT) is employed to process initial features and corresponding adjacency information. GAT identified significant neighbouring nodes in the network, capturing intricate relationships between lncRNAs and diseases, and generating new feature representations. Subsequently, the transformer captures global dependencies and interactions across the entire sequence of features produced by the GAT. Consequently, iGATTLDA successfully captures complex relationships and interactions that conventional approaches may overlook. In evaluating iGATTLDA, it attained an area under the receiver operating characteristic (ROC) curve (AUC) of 0.95 and an area under the precision recall curve (AUPRC) of 0.96 with a two‐layer multilayer perceptron (MLP) classifier. These results were notably higher compared to the majority of previously proposed models, further substantiating the model’s efficiency in predicting potential lncRNA‐disease associations by incorporating both local and global interactions. The implementation details can be obtained from https://github.com/momanyibiffon/iGATTLDA.
Deposition of insoluble calcium phosphate layers by combining finely dispersed calcium hydroxide sols with soluble phosphates
Authors: Tigrano Antonia , Ziegenbalg Gerald 
Published: September 2024

Carbonate containing materials are subject to severe weathering. Traditional formulations of stone strengtheners have low compatibility with the original material and further they contain VOCs (volatile organic compounds), which endanger human health and the environment.
This study explores the high potential of novel treatments based on water-soluble phosphates used as an agent to react with calcium carbonate (CaCO3) to form an insoluble film of calcium phosphate in the pore space of the treated material. Pretreatments with nanolime suspensions ensure greater availability of calcium ions and reduce the consumption of the original material in the reactions. An alkaline environment is required to promote the conversion of the CaCO3 components to hydroxyapatite-like compounds. Based on experiments in aqueous solutions, different sources of phosphate ions could be examined and compared for the development of effective treatments to apply on different test specimens. To implement the treatments, barium phosphate solutions were investigated. Important aspects of this research are the use of green solvents and the search of components that avoid the formation of byproducts, to increase the efficiency of the chemical reactions and reduce possible negative effects on the operator, the environment and the very same built heritage material.
The developed treatments are a valuable alternative to the traditional methods, as it follows an improvement in the material properties without affecting the moisture transport within it and allows the evenly reaction of the strengthened material to external physical and mechanical stresses without creating internal tension between the grains.
Introduction aux résections apicales chez le lapin et les Caviomorphes
Authors: Rosas-Navarro José 
Published: September 2024

Les maladies dentaires sont courantes chez de nombreuses espèces de mammifères exotiques de compagnie, en particulier les Lagomorphes et les Caviomorphes à dentition élodonte (croissance continue), comme les lapins, cobayes, chinchillas et octodons. Malgré une meilleure prévention et un meilleur traitement, la gestion des maladies dentaires reste toujours un défi pour le propriétaire de l’animal comme pour le vétérinaire. Des complications post-chirurgicales et des récidives peuvent survenir et être à l’origine de chirurgies dentaires répétées sous anesthésie générale. Un tel résultat peut entraîner un coût important pour le propriétaire et un risque anesthésique croissant pour le patient. En dentisterie vétérinaire, on utilise régulièrement l’apicectomie, qui consiste à extraire la pointe de la « racine » (couronne de réserve) de la dent infectée ou fracturée. L’apicectomie chez les Lagomorphes et les Caviomorphes est une technique peu décrite dans la littérature. Il s’agit cependant d’une option thérapeutique qui offre une alternative très intéressante à l’extraction dentaire chez ces espèces.
Schnelle Schritte nach der Sommerpause
Authors: Lukuc Sarah 
Published: September 2024

ZusammenfassungSchon vor der Sommerpause kündigte Bundesgesundheitsminister Lauterbach das Pflegekompetenzgesetz an. Dieses Versprechen hat er leider nicht gehalten. Dafür hat der Minister jetzt, innerhalb von einer Woche, die ausstehenden Referentenentwürfe zur Pflegefachassistenzausbildung und zum Pflegekompetenzgesetz vorgelegt.
Aus der Pflege für die Pflege
Authors: Lukuc Sarah , Roßius Sabrina 
Published: September 2024

ZusammenfassungAls Standardeigner hat der Bundesverband Pflegemanagement mit unterschiedlichen ­Akteuren aus der
Gesundheitsversorgung Kriterien erarbeitet, die einen attraktiven Arbeit­geber ausmachen. Die
Ausgestaltung erfolgt individuell vor Ort in den Kliniken.
Monitoring Anesthetic Depth Using the Patient State Index in
Electroconvulsive Therapy Improves Seizure Quality
Authors: Alcoverro-Fortuny Oscar , Viñas Usan Ferran , Sanabria Carmen E. , Esnaola Mikel , E. Rojo Rodes José 
Published: September 2024

Abstract
Objectives The determination of anesthetic depth has been used to assess
the optimal moment for applying electrical stimuli in electroconvulsive therapy
(ECT), as some of the anesthetics used can reduce its effectiveness. In this
study, seizure quality was assessed using anesthetic depth measurement with the
patient state index (PSI).
Methods A prospective experimental study was conducted with a control
group, including a sample of 346 stimulations (PSI=134; Control=212) in 51
patients admitted and diagnosed with major depressive disorders. Seizure
adequacy variables (seizure time in electroencephalogram [EEG] and motor
activity, visual evaluation of the EEG, ECT-EEG parameter rating scale [EEPRS],
seizure concordance, central inhibition, automated parameters, and autonomic
activation) were assessed using linear mixed-effects models for continuous
variables and generalized linear mixed-effects models for dichotomous
variables.
Results The PSI group required lower stimulation energy. The use of the
PSI was associated with longer seizure time, both motor and
electroencephalographic, higher quality of the EEG recording, better seizure
concordance, and higher values for the automated parameters of maximum sustained
coherence and time to peak coherence.
Conclusions The use of the PSI to measure anesthetic depth may reduce the
electrical stimulus charge required and improve seizure quality in ECT modified
with propofol.
Physical Activity Levels in Children with Esophageal Atresia and Congenital Heart Disease: A Comparative Multicenter Study
Authors: Frankenbach Luisa Maria , Holler Anne-Sophie , Oetzmann von Sochaczewski Christina , Wessel Lucas , Muensterer Oliver J. , Dingemann Jens , Widenmann Anke , Helm Paul , Siaplaouras Jannos , Bauer Ulrike , Apitz Christian , Niessner Claudia , König Tatjana Tamara 
Published: September 2024

Aim of the Study Esophageal atresia (EA) is associated with impaired motor development, cardiopulmonary function, and physical activity (PA). Despite missing scientific evidence, this fact is often attributed to associated congenital heart disease (CHD). The aim of this study was to investigate PA in EA patients without CHD compared with CHD patients and healthy controls.
Methods In this multicenter study, EA patients aged 6 through 17 years were included. Moderate-to-vigorous PA (MVPA, minutes per week) was assessed using the standardized and validated questionnaire Motorik-Modul Physical Activity Questionnaire. EA patients were randomly matched 1:4 for gender and age with patients with CHD (n = 1,262) and healthy controls (n = 6,233). Patients born with both EA and CHD were excluded. Means and 95% confidence intervals (95% CIs) were calculated. To identify associated factors, Spearman's correlation was performed.
Main Results Overall, 69 EA patients were matched with 276 CHD patients and 276 controls (57% male, 43% female, mean age 10,3 years, 95% CI: 9.5–11.1). Mean MVPA was reduced in EA (492 minutes, 95% CI: 387–598) and CHD patients (463 minutes, 95% CI: 416–511) compared with controls (613 minutes, 95% CI: 548–679). In subgroup analysis, MVPA was reduced further in females and older age groups with EA and CHD. For EA patients, there was no statistical association between Gross type, current symptoms, surgical approaches, and MVPA.
Conclusion Isolated EA and CHD were associated with reduced PA, especially in females and teenagers. To avoid additional morbidity associated with sedentary behavior, PA should be promoted during follow-up.
Synthesis of Diaryl Diselenides and Ditellurides via Bromide-Catalyzed C–Se/C–Te Bond Formation Using Se/Te Powder and Boronic Acid
Authors: Cai Jinhui , Shen Wangzhen , Cen Kaili , Zeng Zhouting 
Published: September 2024

AbstractDiaryl diselenides and diaryl ditellurides are commonly employed as selenyl or telluryl sources, and they have a wide range of applications in organic synthesis. Herein, various diaryl diselenides/ditellurides are furnished in moderate to excellent yields under metal-free conditions. This method features high efficiency, good functional group tolerance, straightforward operation, and easy scale-up (running in 4 mmol-scale for most cases). Mechanistic studies indicate that this reaction may proceed via a radical pathway. Significantly, the correct matching of Br– and dimethyl sulfoxide under an air atmosphere is critical to this transformation.
Fantasies and Fallacies of ‘Aesthetic’ Instagrammers
Authors: Sharma Mrigya , Dhakad Abhishek , Sharma Sandeep 
Published: September 2024

AbstractThe influence of Instagram, as a social media platform, in shaping perceptions of aesthetic surgery cannot be understated. The idea of a more “aesthetic” self cultivates a desire for cosmetic enhancements. This article underscores the profound impact of Instagram on aesthetic surgery, shedding light on both its fantasies and fallacies. Instagram, a medium for dissemination of content, often blurs the lines between fantasy and reality. Although the intent is to transfer credible information from the provider to the consumer, Instagram often contributes to the distortion of one's self-image and creates unrealistic expectations. Moreover, the glamorization of aesthetic surgery as a fast, effortless fix, often by commercially run enterprises, leads to misconceptions and impulsive decision-making. These fallacies are further compounded by the increase of misinformation and deceptive practices, presenting ethical challenges for influencers and surgeons alike. This study explores the ethical responsibilities of these “Aesthetic Instagrammers,” emphasizing the necessity for transparency and ethical guidelines, while analyzing all the social media stakeholders and providing suggestions for better engagement.
Investigating the Use of Natural Hydrophobic Deep Eutectic Solvents for Extracting Carotenoids from Food and Food By-products
Authors: Sportiello Lucia 
Published: September 2024

Abstract

In today’s food industry, the demand for sustainable methodologies in producing health-promoting natural products is rising. Traditional extraction techniques are increasingly deemed unreliable due to environmental concerns. To address these challenges, the scientific community has developed
Green Chemistry
, a specialized branch that aims to minimize or eliminate hazardous processes and substances in industrial applications. One promising and eco-friendly alternative emerging from Green Chemistry is the use of NaDESs which are prepared with natural components, generally recognized as safe (GRAS), and offer an environmentally benign option for various industrial processes. They are characterized by their biodegradability, low toxicity, and ability to be tailored for specific applications, making them an ideal choice for green extraction methods. In this context, NaHDESs have shown significant potential as extracting media for bioactive compounds, particularly carotenoids, from food and food by-products. Carotenoids, known for their antioxidant properties and health benefits, are highly sought after in the food and nutraceutical industries. Traditional extraction methods often rely on organic solvents, which pose environmental and health risks. In contrast, NaHDESs offer a safer and more sustainable alternative. This study explores the definition, properties, and applications of NaHDESs, with a particular focus on their use in extracting carotenoids. By examining various food and vegetable by-products, the research aims to evaluate the solvent’s efficiency and effectiveness in this application. The findings could pave the way for eco-friendly extraction techniques in the food industry, aligning with the principles of Green Chemistry and addressing the growing demand for natural and health-promoting products.

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Magnetism Measurements of Two-Dimensional van der Waals Antiferromagnet CrPS4 Using Dynamic Cantilever Magnetometry
Authors: Li 李 Qi 奇 , Zhen 甄 Weili 伟立 , Wang 王 Ning 宁 , Shi 史 Meng 猛 , Yu 余 Yang 洋 , Pan 潘 Senyang 森洋 , Deng 邓 Lin 淋 , Cai 蔡 Jiaqiang 佳强 , Wang 王 Kang 康 , Zou 邹 Lvkuan 吕宽 , Zeng 曾 Zhongming 中明 , Wang 王 Zhaosheng 钊胜 , Zhang 张 Jinglei 警蕾 
Published: September 2024

Abstract
Recent experimental and theoretical work has focused on two-dimensional van der Waals (2D vdW) magnets due to their potential applications in sensing and spintronics devises. In measurements of these emerging materials, conventional magnetometry often encounters challenges in characterizing the magnetic properties of small-sized vdW materials, especially for antiferromagnets with nearly compensated magnetic moments. Here, we investigate the magnetism of 2D antiferromagnet CrPS4 with a thickness of 8 nm by using dynamic cantilever magnetometry (DCM). Through a combination of DCM experiment and the calculation based on a Stoner–Wohlfarth-type model, we unravel the magnetization states in 2D CrPS4 antiferromagnet. In the case of H ∥ c, a two-stage phase transition is observed. For H ⊥ c, a hump in the effective magnetic restoring force is noted, which implies the presence of spin reorientation as temperature increases. These results demonstrate the benefits of DCM for studying magnetism of 2D magnets.