bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody
Authors: Logovinsky Veronika , Satlin Andrew , Lai Robert , Swanson Chad , Kaplow June , Osswald Gunilla , Basun Hans , Lannfelt Lars 
Published: March 2016

Abstract
Background
Several monoclonal antibodies for the treatment of Alzheimer’s disease (AD) have been in development over the last decade. BAN2401 is a monoclonal antibody that selectively binds soluble amyloid β (Aβ) protofibrils.

Methods
Here we describe the first clinical study with BAN2401. Safety and tolerability were investigated in mild to moderate AD. A study design was used with staggered parallel single and multiple ascending doses, from 0.1 mg/kg as a single dose to 10 mg/kg biweekly for four months. The presence of amyloid related imaging abnormalities (ARIA, E for edema, H for hemorrhage) was assessed with magnetic resonance imaging (MRI). Cerebrospinal fluid (CSF) and plasma samples were analyzed to investigate pharmacokinetics (PK) and effects on biomarkers.

Results
The incidence of ARIA-E/H on MRI was comparable to that of placebo. BAN2401 exposure was approximately dose proportional, with a serum terminal elimination half-life of ~7 days. Only a slight increase of plasma Aβ(1-40) was observed but there were no measurable effects of BAN2401 on CSF biomarkers. On the basis of these findings Phase 2b efficacy study has been initiated in early AD.

Conclusions
BAN2401 was well-tolerated across all doses. The PK profile has guided us for selecting dose and dose regimens in the ongoing phase 2b study. There was no clear guidance for an effective dose based on biomarkers.

Trial registration number
NCT01230853 ClinicalTrials.gov Registered October 27, 2010.
Selective use of percutaneous testis biopsy to optimize IVF-ICSI outcomes: a case series
Authors: Hayden Russell P. , Wright Diane L. , Toth Thomas L. , Tanrikut Cigdem 
Published: March 2016

AbstractBackgroundSperm quality may degrade during transit through the male reproductive tract in some individuals. In this setting surgically retrieved testicular sperm may outperform ejaculated samples for use with in vitro fertilization (IVF) and intracytoplasmic sperm injection (IVF-ICSI). We sought to describe one center’s experience with the use of fresh testicular sperm after prior failed IVF-ICSI with ejaculated samples.ResultsA retrospective review was conducted evaluating IVF-ICSI cycles performed at a tertiary IVF unit between 2009 and 2014. Couples who were managed with percutaneous testis biopsy to obtain sperm, despite availability of ejaculated sperm, were included. Four couples who underwent a total of 6 percutaneous testis biopsy/IVF-ICSI cycles were identified. Collectively, the couples had undergone 9 prior IVF-ICSI cycles using fresh ejaculated sperm without successful pregnancy. From the six cycles that used fresh testicular sperm four live births resulted (1 twin gestation, 3 singletons). Only 1 of the 4 couples remained childless.ConclusionsFor patients who have had prior failed IVF-ICSI attempts, this small case series demonstrates a possible therapeutic benefit when freshly procured testicular sperm are used in lieu of ejaculated samples.
Smithornis broadbills produce loud wing song by aeroelastic flutter of medial primary wing feathers
Authors: Clark Christopher J. , Kirschel Alexander N. G. , Hadjioannou Louis , Prum Richard O. 
Published: March 2016

ABSTRACT
Broadbills in the genus Smithornis produce a loud brreeeeet during a distinctive flight display. It has been posited that this klaxon-like sound is generated non-vocally with the outer wing feathers (P9, P10), but no scientific studies have previously addressed this hypothesis. Although most birds that make non-vocal communication sounds have feathers with a shape distinctively modified for sound production, Smithornis broadbills do not. We investigated whether this song is produced vocally or with the wings in rufous-sided broadbill (S. rufolateralis) and African broadbill (S. capensis). In support of the wing song hypothesis, synchronized high-speed video and sound recordings of displays demonstrated that sound pulses were produced during the downstroke, subtle gaps sometimes appeared between the outer primary feathers P6–P10, and wingtip speed reached 16 m s−1. Tests of a spread wing in a wind tunnel demonstrated that at a specific orientation, P6 and P7 flutter and produce sound. Wind tunnel tests on individual feathers P5–P10 from a male of each species revealed that while all of these feathers can produce sound via aeroelastic flutter, P6 and P7 produce the loudest sounds, which are similar in frequency to the wing song, at airspeeds achievable by the wing tip during display flight. Consistent with the wind tunnel experiments, field manipulations of P6, P7 and P8 changed the timbre of the wing song, and reduced its tonality, demonstrating that P6 and P7 are together the sound source, and not P9 or P10. The resultant wing song appears to have functionally replaced vocal song.
Larval starvation improves metabolic response to adult starvation in honey bees (Apis mellifera L.)
Authors: Wang Ying , Campbell Jacob B. , Kaftanoglu Osman , Page Robert E. , Amdam Gro V. , Harrison Jon F. 
Published: March 2016

ABSTRACT
Environmental changes during development have long-term effects on adult phenotypes in diverse organisms. Some of the effects play important roles in helping organisms adapt to different environments, such as insect polymorphism. Others, especially those resulting from an adverse developmental environment, have a negative effect on adult health and fitness. However, recent studies have shown that those phenotypes influenced by early environmental adversity have adaptive value under certain (anticipatory) conditions that are similar to the developmental environment, though evidence is mostly from morphological and behavioral observations and it is still rare at physiological and molecular levels. In the companion study, we applied a short-term starvation treatment to fifth instar honey bee larvae and measured changes in adult morphology, starvation resistance, hormonal and metabolic physiology and gene expression. Our results suggest that honey bees can adaptively respond to the predicted nutritional stress. In the present study, we further hypothesized that developmental starvation specifically improves the metabolic response of adult bees to starvation instead of globally affecting metabolism under well-fed conditions. Here, we produced adult honey bees that had experienced a short-term larval starvation, then we starved them for 12 h and monitored metabolic rate, blood sugar concentrations and metabolic reserves. We found that the bees that experienced larval starvation were able to shift to other fuels faster and better maintain stable blood sugar levels during starvation. However, developmental nutritional stress did not change metabolic rates or blood sugar levels in adult bees under normal conditions. Overall, our study provides further evidence that early larval starvation specifically improves the metabolic responses to adult starvation in honey bees.
The “frosted liver” appearance in hepatic tuberculosis: a rare presentation
Authors: Jain Neeraj , Rissam Harmeet Kaur , Puri Sunil Kumar , Chauhan Udit 
Published: March 2016

Abstract
Tuberculosis is a major re-emerging global health concern. The disease may involve any body system and is a great mimicker of various pathologies owing to its non-specific imaging findings. Herein we report an extremely rare case of atypical tuberculosis of the liver in a young female with complaints of abdominal pain and haematemesis for 10 weeks. Isolated hepatic tuberculosis is a rare entity with &lt; 100 cases reported in the literature. It is therefore important to have a high index of suspicion and be familiar with the atypical imaging findings of abdominal tuberculosis. This discussion highlights the clinical presentation, imaging findings and types of hepatic involvement in tuberculosis.
Air-sea interactions in the marginal ice zone
Authors: Zippel Seth , Thomson Jim 
Published: March 2016

Abstract
The importance of waves in the Arctic Ocean has increased with the significant retreat of the seasonal sea-ice extent. Here, we use wind, wave, turbulence, and ice measurements to evaluate the response of the ocean surface to a given wind stress within the marginal ice zone, with a focus on the local wind input to waves and subsequent ocean surface turbulence. Observations are from the Beaufort Sea in the summer and early fall of 2014, with fractional ice cover of up to 50%. Observations showed strong damping and scattering of short waves, which, in turn, decreased the wind energy input to waves. Near-surface turbulent dissipation rates were also greatly reduced in partial ice cover. The reductions in waves and turbulence were balanced, suggesting that a wind-wave equilibrium is maintained in the marginal ice zone, though at levels much less than in open water. These results suggest that air-sea interactions are suppressed in the marginal ice zone relative to open ocean conditions at a given wind forcing, and this suppression may act as a feedback mechanism in expanding a persistent marginal ice zone throughout the Arctic.
Complications in reverse shoulder arthroplasty
Authors: Barco Raul , Savvidou Olga D. , Sperling John W. , Sanchez-Sotelo Joaquín , Cofield Robert H. 
Published: March 2016

The reported rate of complications of reverse shoulder arthroplasty (RSA) seems to be higher than the complication rate of anatomical total shoulder arthroplasty. The reported overall complication rate of primary RSA is approximately 15%; when RSA is used in the revision setting, the complication rate may approach 40%. The most common complications of RSA include instability, infection, notching, loosening, nerve injury, acromial and scapular spine fractures, intra-operative fractures and component disengagement. Careful attention to implant design and surgical technique, including implantation of components in the correct version and height, selection of the best glenosphere-humeral bearing match, avoidance of impingement, and adequate management of the soft tissues will hopefully translate in a decreasing number of complications in the future.Cite this article: Barco R, Savvidou OD, Sperling JW, Sanchez-Sotelo J, Cofield RH. Complications in reverse shoulder arthroplasty. EFORT Open Rev 2016;1:72-80. DOI: 10.1302/2058-5241.1.160003.
The Future of Patient Engagement in the Governance of Shared Data
Authors: Petersen Carolyn 
Published: March 2016

Background: The emerging health care system increasingly values patient engagement
and shared decision-making between patients and their providers. The practice of these
values is gaining importance as the patient-centered medical home model and personalized
medicine come into greater use.Opportunity for Improvement: Exploration of patient
preferences about personal health data use for research and quality improvement is a
fundamental element of the provider-patient relationship. Giving patients an explicit
opportunity to discuss their options about use of their data and implementing a process
that allows patients to receive desired communications about how their information is
used can help build patient trust, a requirement for successful care
partnerships.Practice Advancement: Working to change organizational cultures that
exclude patients from participation in important decisions related to personal health
information use promotes a strong patient-provider relationship and, ultimately, lays
the foundation for improved health care through expanded use of patient data.
Indikatoren für Risiken bei Kühen in der Transitphase – eine Übersicht zu metabolischen Profilen
Authors: Van Saun R. J. 
Published: March 2016

ZusammenfassungErkrankungen von Milchkühen im peripartalen Zeitraum gelten als entscheidende Faktoren für eine Beeinträchtigung der Milchleistung und sind mittlerweile ein zentraler Aspekt der Herdendiagnostik. In den letzten 40 Jahren wurden anhand von Blutproben erstellte metabolische Profile zur Herdendiagnostik genutzt, wobei die Erfahrungen bezüglich der diagnostischen Wertigkeit differierten. Die Forschung führte zu umfangreichen Erkenntnissen darüber, wie physiologische Mechanismen bei der Kuh, das Management, die Umwelt sowie Interaktionen zwischen diesen Faktoren zur Entwicklung von Erkrankungen im peripartalen Zeitraum beitragen. Kühe mit hohem Risiko für eine erforderlich werdende Behandlung lassen sich anhand einer erhöhten Konzentration an β-Hydroxybutyrat (BHB) (> 1,2 mmol/l) in den ersten 7–10 Tagen nach dem Kalben identifizieren. Ergeben Herdenkontrollen bei 15–20% der Frischabkalber in der ersten Woche post partum erhöhte BHB-Konzentrationen, weist dies auf ein beträchtliches Krankheitsrisiko und Produktionsverluste hin. Auch eine erhöhte Serumkonzentration freier Fettsäuren (FFS) ist Hinweis für ein gesteigertes Krankheitsrisiko. In dieser Übersicht werden gesicherte (BHB, FFS) und weitere potenzielle Parameter erläutert, die sich, bei Untersuchung von Einzel- oder Poolproben, dazu eignen, das Risiko für Erkrankungen und den Ernährungszustand der Tiere einzuschätzen. Ihre Anwendung in Form metabolischer Profile zur Herdendiagnostik bei bestehenden Risiken oder im Rahmen der Herdenüberwachung wird dargestellt. Eine Poolprobe nach dem modifizierten „Compton Metabolic Profile“ ermöglicht die wirtschaftlichere Nutzung mehrerer Parameter, wenngleich diese Vorgehensweise die Interpreta - tion und die Anwendung in Abhängigkeit von der Herdengröße einschränken kann. Poolproben von fünf bis zehn Individuen repräsentieren genau das arithmetische Mittel aus den Werten der einzelnen Tiere. Von größter Bedeutung ist, dass die metabolischen Profile im Zusammenhang mit anderen diagnostischen Kennzahlen von Tier- und Betriebsanalysen, der Körperkonditionsbeurteilung und der Rationskontrolle genutzt werden. Nur so lässt sich ihr Wert im Rahmen der Herdenunter - suchung voll ausschöpfen.
A metarmofose de cupido o discurso erótico de Casimiro de Ábreu
Authors: Almeida Ana Maria De 
Published: March 2016

Resumo: O ensaio demonstra que o êxito da poesia de Casimiro de Abreu se deve ao fato de dar expressão ao erotismo caro à mentalidade feminina no século XIX, assim como ao fato de dar voz ao desejo, nos aspectos do langor e da volúpia, característicos do código de namoro romântico e adolescente.Résumé: Cet essai veut montrer que le succeè de la poésie de Casimiro de Abreu résulte du fait qu'elle réussit à exprimer l'érotisme propre de la mentalité féminine du XIXe siècle de même qu'elle fait parler le désir en tant que langueur et volupté, éléments caractéristiques du code de la conquête amoureuse adolescente.
A comédia da escrita à Maria do Carmo
Authors: Souza Eneida Maria De 
Published: March 2016

Resumo: Esta leitura, centrada na relação entre oralidade e escrita, tem como objeto a reflexão do conceito de memória como processo de composição da poesia oral e de seu registro escrito.Résumé: Cette lecture, centrée sur le rapport entre l'oralité et l'êcriture, a pour objet la réflexion sur le concept de mémorie en tant que procédé de composition de la poésie orale, ainsi que de son registre écrit.
Maíra: leitura/escritura
Authors: Ramos Maria Luiza 
Published: March 2016

Resumo: Maíra lembra uma forma-sonata, pelo caráter dialético dos temas que estruturam o texto: a sociedade civilizada e a sociedade indígena. Nesse romance, que Darcy Ribeiro escreveu quando era ainda um exilado político, as contradições que se desenvolvem a partir do tratamento parodístico do Isaías bíblico - mediador entre dois mundos - convivem hoje com uma contradição não programada pelo texto: "E te restituirei os teus juízes como eram dantes; e os teus conselheiros, como antigamente." (Isaías, I, 26).Résumé: Maíra évoque une forme-sonate, par le caractére dialectique des thèmes qui structurent le texte: la société civilisée et la société indienne. Dans ce roman, écrit quand Darcy Ribeiro se trouvait encore à l'exil, les contradictions qui se developpent à partir de la parodie de l'Isaie biblique - médiateur entre deux mondes - coexistent aujurd'hui avec une contradiction qui n'est pas programmée par le texte: "Et je te restituierai tes juges tel qu'ils êtaient auparavant; et tes conseillers, comme autrefois." (Isaie, I, 26).
Planificación, control y seguimiento de un servicio profesional de ingeniería de edificación en un modelo de gestión de la calidad según ISO 9001
Authors: González Ponce Eloísa , Roldán Ruiz Juan , Parra Meroño María Concepción 
Published: March 2016

ResumenEste trabajo propone una documentación original, de desarrollo propio, relacionada con la planificación, control y seguimiento de un encargo de trabajo profesional de ingeniería de edificación dentro de un Modelo de Sistema de Gestión de la Calidad, cuya implantación pretende mejorar los resultados de los servicios prestados y aumentar la satisfacción del cliente. AbstractThis paper proposes an original documentation self-developed, related to the planning, control and monitoring of professional work of engineering building commissioned within a System Model Quality Management, whose implementation aims to improve the results and increase the customer satisfaction.
EVALUASI STATUS VIRULENSI ISOLAT Bacillus anthracis ASALNUSA TENGGARA DAN PAPUA MENGGUNAKAN METODE POLYMERASE CHAIN REACTION MULTIPLEX
Authors: Ebenhaizar Sanam Maxs Urias , Asmara Widya , Tri Hastuti Wahyuni Agnesia Endang , Wibowo Michael Haryadi , Adji Rahmat Setya 
Published: March 2016

Penelitian ini bertujuan mengevaluasi status virulensi 22 isolat Bacillus anthracis (B. anthracis) asal Nusa Tenggara dan Papua menggunakan metode polymerase chain reaction (PCR) multiplex dengan dua pasang primer nukleotida yang memiliki target amplifikasi gen spesifik pada kedua plasmid. Ektraksi DNA dilakukan dengan metode lisis panas. Pasangan primer PA5 dan PA8 digunakan untuk mengamplifikasi gen pagA pada pXO1, sedangkan pasangan primer 1234 F dan 1301 R mengamplifikasi gen capABC pada pXO2. Hasil reaksi PCR menghasilkan dua pita DNA berukuran sekitar 600 dan 800 bp pada 20 isolat. Namun, dua isolat lain, masing-masing hanya memiliki salah satu dari kedua ukuran pita DNA tersebut. Sebagian besar koleksi isolat asal Nusa Tenggara dan Papua (91%) masih memiliki kedua plasmid secara lengkap (pXO1+/2+) dan karena itu bersifat virulen, sedangkan dua isolat lain (9%) telah kehilangan salah satu plasmid virulennya sehingga bersifat avirulen. Disimpulkan bahwa PCR multiplex dengan dua pasang primer dengan target amplifikasi pada plasmid dapat digunakan untuk evaluasi status virulensi isolat B. anthraci.
Energy 360: Invited Perspective: Reservoir Modeling Today and Tomorrow
Authors: Haldorsen Helge , Leach Patrick 
Published: March 2016

President's column
Reservoir performance forecasting is still the “Grand Central Station” of all the exploration and production (E&P) disciplines because this is where everything (the large-scale reservoir plumbing system, reservoir properties, fluid properties, wells, completions, lift curves/hydraulics, facilities, fluid handling capacities, and much more) is integrated and comes together in a life-of-field forecast. The revenue from the field development is the composite oil and gas production rates into the future multiplied by the forward oil and gas prices. The reservoir description, which I call the “subsurface plumbing system,” in a forecasting model can range from a simple homogeneous analytical tank model to an unbelievably complex dual porosity, compositional simulation model with one billion grid cells, pseudos ( from endless upscaling), and many other sophisticated features built in to try to mimic a very complex reality. I had the opportunity to discuss the state of the art and the future of reservoir modeling and reservoir performance forecasting with one of the finest members of the reservoir engineering profession, professor Larry W. Lake, of the University of Texas at Austin (UT).
You have taught reservoir modeling to undergraduates and graduate students for more than 30 years. How has the reservoir modeling discipline evolved?
The biggest evolution has been caused by the capacity of computers. The capacity has allowed combinations of traditional simulation with facilities, improved resolution of heterogeneity, progress in automated history matching, and uncertainty estimation to name just a few.
In order for universities such as UT to understand the main reservoir modeling challenges of the E&P industry, close collaboration and a dialogue on real industry needs must happen. What is your view of the state of industry/academia collaboration? Are you collaborating more with service companies than with international oil companies, national oil companies, and independents?
We at UT do well in the collaboration department and on all the major avenues of E&P. The challenge for us is the boundary between technology development and research. We do, or at least we should do, research.
Evaluation and comparison of xylazine hydrochloride and dexmedetomidine hydrochloride for the induction of emesis in cats: 47 cases (2007–2013)
Authors: Willey Jennifer L. , Julius Tracy M. , Claypool Sean-Paul A. , Clare Monica C. 
Published: March 2016

Abstract
OBJECTIVE To evaluate and compare IM administration of xylazine hydrochloride and dexmedetomidine hydrochloride for the induction of emesis in cats.
DESIGN Retrospective case series.
ANIMALS 47 cats with a history of suspected ingestion of a toxic substance or foreign material between June 2007 and June 2013.
PROCEDURES Data collected for analysis from the medical records included signalment, drug dose and route of administration, whether a repeated dose of the emetic agent was administered, and outcome (emesis, yes or no).
RESULTS Cats in the 2 treatment groups did not differ with regard to age, sex, or breed distribution. The range of doses of xylazine administered IM was 0.36 to 0.64 mg/kg (0.16 to 0.29 mg/lb). The range of doses of dexmedetomidine administered IM was 6 to 18 μg/kg (2.7 to 8.2 μg/lb). A repeated dose of xylazine or dexmedetomidine was given to 3 and 1 cats, respectively. Emesis was successfully induced in 24 of the 47 (51.1%) cats. Nine of the 21 (43%) cats that received xylazine vomited and 15 of the 26 (58%) cats that received dexmedetomidine vomited. Percentage of cats that vomited after either drug administration did not differ significantly.
CONCLUSIONS AND CLINICAL RELEVANCE Following IM administration in cats, xylazine and dexmedetomidine were similarly effective for induction of emesis, indicating that dexmedetomidine is a comparable alternative to xylazine for this purpose. Prospective studies are needed to determine the optimal IM dose of dexmedetomidine for induction of emesis in cats.