bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Serum Beta 2-microglobulin (β2 M) and Lipid Bound Sialic Acid (Lsa) Levels in Oral Carcinoma Patients
Authors: Kapoor Anurag , Sharma Pradeep , Kumar Ajai , Mittal Kailash K , Chauhan Jitendra Pratap Singh , Nardev  , Singh Amit Kumar , Singh Kumar 
Published: October 2024

Abstract

Background:
Oral cancer is a significant global health issue, and nearly one-third of cases are in India. The late-stage diagnosis common in India leads to poor survival outcomes, highlighting the need for early detection and effective biomarkers.
Introduction:
This study explored the potential of serum β2-microglobulin (β2 M) and lipid-bound sialic acid (LSA) as diagnostic and prognostic biomarkers for oral carcinoma, with a focus on the Indian population, where the disease burden is exceptionally high.
Methodology:
This case‒control study involved 200 participants (100 oral cancer patients and 100 healthy controls) aged > 20–60 years. Serum β2 M and LSA levels were measured using ELISA kits. All the statistical analyses, including ROC analysis and correlation studies, were performed using SPSS software to assess the diagnostic accuracy and clinical relevance of these biomarkers.
Results:
Serum β2 M and LSA levels were significantly greater in oral cancer patients than in controls, with β2 M showing near-perfect diagnostic accuracy (AUC 0.999) and LSA demonstrating excellent accuracy (AUC 0.945). Both biomarkers strongly correlated with advanced AJCC stages, underscoring their potential in assessing disease severity and aiding early detection.
Conclusion:
Serum β2 M and LSA levels are promising biomarkers for the diagnosis and assessment of oral carcinoma. Their incorporation into clinical practice could enhance early detection, prognosis, and treatment monitoring, ultimately improving patient outcomes. However, further research with larger cohorts is needed to validate these findings and explore their longitudinal applicability.
Bio-resistant construction materials to enhance the ecological sustainability of structures and buildings
Authors: Al-Dulaimi Salman , Anatolyevich Svetlov Dmitry 
Published: October 2024

Abstract

Current attention is mostly directed towards the matter of ensuring safe human habitation in residential and commercial settings, as well as in other biological categories. Microorganisms that arise in the soil, with a little atmospheric movement, are carried over vast distances and build up in enclosed spaces. Under these circumstances, minuscule organisms can lead to allergies, mycotic lung infections, Sick Building Syndrome (SBS), and the degradation of construction items and materials. This essay explores the potential environmental benefits of using biocidal chemicals and materials in buildings. In the construction and maintenance of buildings and structures, composite materials composed of several binders are used. The detailed study materials and methodologies are provided. Teflex-modified gypsum composites are classified as materials in further development. Teflex's capacity to bind to cell walls and membranes, penetrate cell nuclei, and suppress cellular enzymes allows it to effectively prevent bacterial growth. Empirical investigations have proven the most effective quantitative composition of the biocidal additive. Utilising biocidal gypsum composites enhances the environmental conditions in urban buildings and structures.This study aimed to improve building conditions by integrating stable biological products and gypsum compounds with biocidal additives. To manufacture a modified gypsum plaster, the work employs TFLEX, a guanidine actuator-based chemical that activates biological enzymes in nocturnal bacteria when added to cell walls and cells. The number of examples showcasing the substantial significance of biosides in improving programming environment optimization has increased.Innovative composite materials with biocidal additives are used in this work to eliminate bacteria and fungi in buildings and structures, without the need of pesticides, therefore reducing biological degradation. The importance of pre-designing construction materials to prevent biological harm is emphasized in this paper. A novel approach is suggested for the direct integration of biocidal chemicals into construction materials, therefore extending their durability and protecting the indoor environment.
Безотносительное и независимое. О различии терминов и слов в «Критике чистого разума» Канта
Authors: Молчанов В.И 
Published: October 2024

Различие анализа и интерпретации - основа исследования контекстов, в которых функционирует кантовский термин Ding an sich, а также другие термины, имеющие в своем составе структуру an sich. Исходя из различия между безотносительностью и независимостью анализируются переводы этих терминов в пяти изданиях «Критики чистого разума» И. Канта на русском языке. Рассматривается различие между терминами и сходными языковыми выражениями, не являющимися терминами. Особое внимание уделяется различию конкурирующих терминов «вещь в себе» и «вещь сама по себе». Выявляется тавтологический характер определений вещи в себе и явлений у Канта; выявляется также основание для многообразия интерпретаций «вещи в себе».
The difference between analysis and interpretation is the basis for studying the contexts in which the Kantian term Ding an sich operates, as well as other terms that include the structure an sich. Based on the difference between irrelativeness and independence, translations of these terms in five editions of the Critique of Pure Reason in Russian are analyzed. The difference between terms and similar language expressions that are not terms is considered. Particular attention is paid to the distinction between the competing terms «Ding an sich selbst» and «Sache an sich selbst», as well as to the term “Affizierung”, which does not exist in Kant’s language but is used by Russian translators and researchers. The tautological character of the definitions of things in themselves and of phenomena in Kant is clarified. The basis for the variety of interpretations of the “thing-in-itself” is revealed. In any discussion of any objects, there is always an explicit or implicit, reference to experience. No exception is any argument about things in themselves. When trying to describe them, they acquire, in the final analysis, the characteristics of cognizable and identifiable things that function in different spaces of the human world.
Единство платоновского «Государства»: два типа эйдосов
Authors: Протопопова И.А 
Published: October 2024

Статья посвящена проблеме единства государства и души в платоновском «Государстве», а также вопросу единства самого текста диалога. Содержательное единство «Государства» рассматривается сквозь призму двух разных типов эйдосов (пронизывающий и собирательный) и структуры текста. Автор полагает, что пронизывающий эйдос справедливости связывает в данном диалоге собирательные эйдосы души и государства, и подобная модель «целого», встречаясь по меньшей мере в диалогах «Пир», «Софист» и «Тимей», является своего рода решением одной из важнейших для Платона проблем «единое//многое». Работа состоит из трех частей: в первой разбираются два типа эйдосов; во второй прослежено, как конкретно разыгрывается в диалоге их взаимодействие с точки зрения содержания; в третьей кратко показано, как это преломляется в самой структуре текста.
The article deals with the problem of the unity of state and soul in Plato’s Republic , as well as the unity of the dialogue itself. The substantial unity of the State is considered through the prism of two different types of eidos (permeating and collective) and the structure of the text. The author believes that the permeating eidos of justice connects the collective eidos of the soul and the state in this dialogue. Such a model of the "whole" is found at least in the dialogues Symposium , Sophist and Timaeus and is a kind of solution to one of the most important problems for Plato "one//many". The work consists of three parts: the first deals with two types of eidos; the second traces how their interaction in terms of content is played out in the dialogue; the third briefly shows how it is refracted in the structure of the text.
Metaphysics and Morality
Authors: Ravaisson F , Blauberg I.I 
Published: October 2024

The work of the French philosopher-spiritualist Felix Ravaisson “Metaphysics and Morality” is translated into Russian by Irina Blauberg from edition: F. Ravaisson, “Métaphysique et morale”, Revue de Métaphysique et de Morale , 1893, № 1, pp. 6-25. In this paper, Ravaisson expounds his ideas about true metaphysics, tracing its origins in the ideas of the philosophers of antiquity and modern times. In his opinion, the practical expression of this metaphysical theory is the ideal of generosity and self-sacrifice, that underlies “heroic philosophy”.
Публикация представляет собой первый перевод на русский язык работы французского философа-спиритуалиста Феликса Равессона (1813-1900) «Метафизика и мораль». В данной работе Равессон излагает свои представления о подлинной метафизике, прослеживая ее истоки в идеях философов древности и Нового времени. Практическим выражением этой метафизической теории он считает идеал великодушия и самопожертвования, лежащий в основе «героической философии». Перевод выполнен И.И. Блауберг по изданию: Ravaisson F. Métaphysique et morale // Revue de Métaphysique et de Morale. 1893. № 1. P. 6-25.
Теория восприятия в «Теэтете» и «Тимее» Платона
Authors: Волкова Н.П. 
Published: October 2024

В статье рассматривается учение Платона о чувственном восприятии и предлагается его понимание как единого учения на основании текстов двух диалогов Теэтета и Тимея . В начале исследования автор анализирует две интерпретации теории ощущений Платона в Теэтете , согласно которым эта теория (1) является пересказом теории Протагора либо (2) принадлежит самому Платону. Автор статьи, придерживаясь второй точки зрения, стремится показать, что диалог Тимей предоставляет необходимый контекст для интерпретации теории восприятия, изложенной в Теэтете . В результате исследования автор приходит к следующим выводам: что в Теэтете имеются прямые отсылки к тексту Тимея , в котором теория восприятия дана в математической (пифагорейской) интерпретации что математическая интерпретация процесса восприятия является необходимым дополнением к теории восприятия в Теэтете , где используются понятия меры и соразмерности в описании указанного процесса, и наконец, что математическая интерпретация теории восприятия не противоречит ходу рассуждений Платона в Теэтете .
In this article an author discusses Platos doctrine of sense perception and offers its interpretation as a united consistent theory based on the texts of two dialogues Theaetetus and Timaeus. In the beginning of the study the author analyzes two ways of interpretation of Platos theory of perception in Theaetetus. According to the first method, this theory is a paraphrase of the theory of Protagoras according to the second, it belongs to Plato himself. The author of the article adheres to the second point of view and tries to show that Timaeus provides the necessary context for interpreting the theory of perception set forth in Theaetetus. As a result of the study the author comes to the following conclusions: 1) there are direct references to the Timaeus in the text of Theaetetus, in which the theory of perception is given in mathematical (Pythagorean) interpretation 2) the mathematical interpretation of theprocess of perception is a necessary addition to the description of perception in Theaetetus, which uses the concepts of measure and proportionality in the explanation of the process of perception 3) and finally, the mathematical interpretation of thetheory of perception does not contradict Platos thought in Theaetetus.
Религия и философия в дневнике Анри Амьеля
Authors: Визгин В.П. 
Published: October 2024

Автор статьи исследует соотношение религии и философии в дневнике Анри Амьеля (18211881) и приходит к выводу, что в молодые годы Амьель был скорее учеником Шеллинга, чем Гегеля, разделяя шеллингианскую позицию позитивности и признавая первенство религии перед философией в домостроительстве духа. В дальнейшем, по мнению автора статьи, успехи наук о природе подталкивали швейцарского философа к переосмыслению разделяемого им ранее соотношения религии и философии, в результате чего трансцендентный Бог уходит с горизонта его мысли и его место занимает имманентный бог философов-рационалистов. Как показывает автор статьи, Амьель колеблется между теизмом и пантеизмом, соответственно, между Лейбницем и Спинозой таким образом, что философия и религия у него сходятся в понятии идеала и долга, предполагающих спиритуалистическое понимание бытия.
In this article is analyzed the relation between religion and philosophy in the diary of the Suisse philosopher Henri Amiel (18211881). The author demonstrates that Amiel at young years most likely was the pupil of Schelling than Hegels one and recognized the primacy of religion in front of philosophy. But after, as the author means, he changed his attitude concerning this fundamental relation. As a result of this transformation the transcendent God replaced by the immanent one. In this article the author expresses the opinion that Amiel hesitate between theism and pantheism, respectively Leibnitz and Spinoza. The notions of ideal and duty in theirs jointing resumes Amiels spiritualism.
Осмысление феномена святости в религиозной философии С.А. Алексеева (Аскольдова)
Authors: Бердникова А.Ю. 
Published: October 2024

В статье анализируются основные идеи русского религиозного философа эпохи Серебряного века Сергея Алексеевича Алексеева (Аскольдова). Раскрываются основные моменты его личной и творческой биографии. Рассматривается весь широкий спектр философских увлечений мыслителя, сформировавший его собственные идеи: от теории познания и панпсихизма его отца А.А. Козлова, до православного богословия и системы христианской политики В.С. Соловьева. В контексте собственных взглядов Аскольдова показана эволюция его представлений о Церкви и святости, что является главным предметом его исследований в работе Святость и ее достижение . Проанализированы основные этапы развития богословских взглядов Аскольдова: от отвлеченного теоретизирования в ранних сочинениях ( Философия и жизнь , 1902) до более конкретных, практических идеалов ( О старом и новом религиозном сознании , 1907 Религиозный смысл русской революции , 1918). На примере работ Четыре разговора и Мысленный образ Христа (19361937) рассмотрен поздний этап развития религиозно-философских идей мыслителя. Кроме того, продемонстрирована связь представлений Аскольдова о святости с аналогичными идеями в рамках русской духовно-академической и светской традиции (в частности, с концепциями В.И. Герье и Л.П. Карсавина).
Article devoted to the analysis of the main ideas of Russian Silver Age religious thinker, Sergey Alekseev (Askoldov). The highlights of his personal life and scientific career are revealed. The whole wide range of Askoldovs philosophical interests, which formed his own ideas is considered: from the theory of knowledge and panpsychism of his father Alexey Kozlov, till Orthodox theology and Vladimir Solovyovs system of Christian politics. In the context of his original views, the evolution of Askoldovs ideas about the Church and holiness is shown, which is the main subject of his research in the following article Holiness and Its Achievements. The main stages of the development of Askoldovs theological views are analyzed: from abstract theorizing in early works (Philosophy and Life, 1902) to more specific, practical ideals (About the old and the new religious consciousness, 1907 Religious meaning of the Russian revolution, 1918). On the example of the works Four Conversations and The Mental Image of Christ (1936-1937), the late stage of Askoldovs religious and philosophical ideas is considered. In addition, the relationship of Askoldovs ideas about holiness with similar ideas in the framework of the Russian spiritual, academic and secular tradition (in particular, with the concepts of Vladimir Guerrier and Lev Karsavin) is demonstrated.
Возможна ли фундаментальная онтология?
Authors: Круглов А.Н. 
Published: October 2024

В статье ставится вопрос о том, возможна ли фундаментальная онтология. Для ответа на него очерчиваются истоки термина “онтология” в XVII в., а также его развитие и видоизменение в XVIII–XIX вв. Происхождение термина “фундаментальная онтология” у М. Хайдеггера, который играет немаловажную роль в таких его сочинениях, как «Кант и проблема метафизики» и «Бытие и время», объясняется аналогией с фундаментальной теологией, а также влиянием сочинений К. Брайга. Претензии Хайдеггера на открывшуюся ему “подлинную” онтологию имели под собой псевдоэтимологические и псевдоисторические, а также сомнительные философские основания. Псевдоэтимологические и псевдоисторические аргументы Хайдеггера проясняются на примере его обращения с сочинениями Баумгартена и Канта. Сомнительные философские основания состоят в невозможности фундаментальной онтологии Хайдеггера претендовать на некую общезначимость и фундаментальность в духе Аристотеля и Канта, анахронических метасциентистских претензиях, вкусовщине и придании трансцендентального характера экзистенциалам. В итоге ответ автора на поставленный вопрос звучит так: в дескриптивном смысле имеется «фундаментальная онтология Хайдеггера», в то время как фундаментальная онтология отсутствует, и ее никогда не было – вероятно, в силу ее невозможности.
The issue of the paper is the question if the fundamental ontology is possible. To answer it, I outline the sources of the term “ontology” in the 17th century and its development and modification in the 18–19th centuries. The contribution argues that the origin of the term “fundamental ontology” in M. Heidegger is due to both the analogy with the fundamental theology and C. Braig’s works’ influence. Heidegger’s claims to the “true” ontology revealed to him had pseudoethymological, pseudohistorical, and doubtful philosophical foundations. Heidegger’s pseudoethymological and pseudohistorical arguments are explained with his treatment of A. G. Baumgarten and I. Kant’s works. Doubtful philosophical foundations are defined with the impossibility of Heidegger’s fundamental ontology to claim to have a certain general significance or fundamentality in Aristotle and Kant's spirit, his anachronistic metascientist claims, personal taste, as well as a wish to ensure transcendental nature to existentials. As a result, the answer to the question is as follows: in a descriptive sense, there is “Heidegger’s fundamental ontology” while there is no fundamental ontology in general, and it has never existed – probably because of its impossibility.
Intraspecific variation of <em>Scorpaenopsis possi</em> Randall et Eschmeyer, 2002 (Pisces: Scorpaenidae)
Authors: Zhukov Mikhail , Fricke Ronald 
Published: October 2024

The genus Scorpaenopsis has been intensively studied in recent decades. Sixteen species were known before the revision by Randall and Eschmeyer, who described 8 new species in 2002, and nowadays 29 species are known. Two specimens of Scorpaenopsis from the collection of the Zoological Institute of the Russian Academy of Sciences are intermediate in a number of parameters between Scorpaenopsis possi Randall et Eschmeyer 2002 and Scorpaenopsis eschmeyeri Randall et Greenfield 2004. The range of S. possi extends from the Indian Ocean coast of Africa and the Red Sea to the Marquesas Islands in the Pacific Ocean, the latitude of the range lies between the 30th latitudes of both hemispheres. The species S. eschmeyeri inhabits a much smaller range from the east coast of Australia to the island of Fiji. The aim of this work is to explain the appearance of S. possi, similar to S. eschmeyeri in some morphological diagnostic characters, almost 12,000 km apart from its range. The number of soft rays in the dorsal fin, which is unusual for the genus Scorpaenopsis, is described. Due to the lack of persistent distinguishing characters between S. possi and S. eschmeyeri, it is highly probable that both are conspecific; in that case S. eschmeyeri would be a junior synonym of S. possi.
Integrated environmental and social assessment of alum-contaminated water in An Giang province
Authors: Nguyen Trung Thanh , Cao Son Dai Hai , Tran Quoc Thao , Le Tri Thich , Nguyen Thi Thuy , Nguyen Thi Quynh Anh , Phan Phuoc Toan , Tran Le Ba , Padungthon Surapol , Huy Nguyen Nhat 
Published: October 2024

ABSTRACT

This study investigates alum-contaminated water in An Giang province within the Mekong Delta, emphasizing methodological approaches to assess its distribution and impacts. The research conducted from March to May 2021 involved surveys of residents, public sector employees, and provincial managers, complemented by expert interviews and extensive fieldwork. Surface water samples were collected during both rainy and dry seasons across three districts, with parameters such as turbidity, pH, and temperature measured onsite, and aluminum (Al), iron (Fe), and copper (Cu) concentrations analyzed in the laboratory using atomic absorption spectrometry. The data were further processed using QGIS software to create comprehensive maps illustrating seasonal variations in water quality. The findings revealed significant spatial and temporal variations in water quality, with pH levels fluctuating markedly between the dry and rainy seasons. Household surveys indicated a lack of awareness regarding effective water treatment methods, with most respondents relying on local authorities for solutions. The study highlights the need for community education and participation in addressing alum contamination, offering insights into the environmental and public health implications of water quality in the region. This research contributes valuable knowledge to the ongoing efforts in environmental conservation and water quality management in the Mekong Delta.
Polymeric Vehicles for Nucleic Acid Delivery: Enhancing the Therapeutic Efficacy and Cellular Uptake
Authors: Gupta Parul , Sharma Anjali , Mittal Vishnu 
Published: October 2024

Background:
Therapeutic gene delivery may be facilitated by the use of polymeric carriers.
When combined with nucleic acids to form nanoparticles or polyplexes, a variety of polymers
may shield the cargo from in vivo breakdown and clearance while also making it easier for it to enter
intracellular compartments.

Aim and Objectives:
Polymer synthesis design choices result in a wide variety of compounds and
vehicle compositions. Depending on the application, these characteristics may be changed to provide
enhanced endosomal escape, longer-lasting distribution, or stronger connection with nucleic
acid cargo and cells. Here, we outline current methods for delivering genes in preclinical and clinical
settings using polymers.

Methodology:
Significant therapeutic outcomes have previously been attained using genetic material-
delivering polymer vehicles in both in-vitro and animal models. When combined with nucleic acids
to form nanoparticles or polyplexes, a variety of polymers may shield the cargo from in vivo
breakdown and clearance while also making it easier for it to enter intracellular compartments.
Many innovative diagnoses for nucleic acids have been investigated and put through clinical assessment
in the past 20 years.

Results:
Polymer-based carriers have additional delivery issues due to their changes in method and
place of biological action, as well as variances in biophysical characteristics. We cover recent custom
polymeric carrier architectures that were tuned for nucleic acid payloads such genomemodifying
nucleic acids, siRNA, microRNA, and plasmid DNA.

Conclusion:
In conclusion, the development of polymeric carriers for gene delivery holds promise
for therapeutic applications. Through careful design and optimization, these carriers can overcome
various challenges associated with nucleic acid delivery, offering new avenues for treating a wide
range of diseases.