bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of diarrheagenic potential of uropathogenic Escherichia coli isolates in Dhaka, Bangladesh
Authors: Khaleque Marium , Akter Selina , Akhter Humaira , Khan Sirajul Islam , Begum Anowara 
Published: July 2017

Abstract
Introduction: Urinary tract infection is the most frequently diagnosed kidney and urologic disease.
Methodology: Whether the Escherichia coli strains responsible for urinary tract infection (UPEC) carry virulence properties of diarrheagenic E. coli (DEC), 56 UPEC strains were examined for the presence of DEC and UPEC characteristics (e.g. biofilm formation, hemolysis activity, virulence genes).
Results: Among 56 UPEC strains, 21 showed capable of biofilm formation and only 5 showed hemolysis activity on sheep blood agar. In Multiplex PCR on assessment of virulence genes related to uropathogenesis; 42% was found positive for papC gene, 27% was fim1 positive, 11% was afa positive and none was found positive for sfa. Most of the isolates were found carrying none of eight diarrhea associated genes (e.g. estA, eltB, vt1, vt2, eaeA, ea, ial and bfpA) as expected. Only seven isolates were found to harbor these genes: five genes i.e., vt2, ial, eltB, bfpA and ea were found in five different isolates and two isolates were positive for estA, among these two, one was found positive for fim1, papC along with estA, a UPEC strain containing virulent gene of ETEC strain. One isolate was found carrying fim1 and vt2 showing the property of EHEC and another isolate was found positive for fim1 and ial, the characteristic of EIEC. One isolate harboring bfpA gene characterized as EPEC and the another one was found to harbor ea gene, characterized as EAEC.
Conclusions: This study observed that most UPEC strains are unique to uropathogenesis, still very few may carry the diarrheagenic property.
Anticyclic Citrullinated Peptide Antibodies and Rheumatoid Factor as Risk Factors for 10-year Cardiovascular Morbidity in Patients with Rheumatoid Arthritis: A Large Inception Cohort Study
Authors: Berendsen Mike L.T. , van Maaren Marissa C. , Arts Elke E.A. , den Broeder Alfons A. , Popa Calin D. , Fransen Jaap 
Published: July 2017

Objective.To determine whether anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) are risk factors for 10-year cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA).Methods.Analyses were performed using data from the Nijmegen early RA inception cohort, in which patients with newly diagnosed RA, consecutively included since 1985, were regularly followed up. Anti-CCP and RF were determined at baseline (diagnosis). Outcome was the first cardiovascular disease (CVD) event [ischemic heart disease, nonhemorrhagic cerebrovascular accident (CVA), or peripheral artery disease (PAD)] after baseline as retrieved from physician diagnosis. Fatality was checked against death certificates. Cox regression including correction for baseline confounders was performed to estimate the effect of anti-CCP, RF, and their interaction on 10-year CVD-free survival.Results.Of 929 patients included, 628 were anti-CCP–positive and 697 were RF-positive. During followup, with a median of 7.5 years, 162 CV events were observed (101 ischemic heart disease, 45 CVA, and 16 PAD), of which 15 were fatal. The HRadjusted for anti-CCP was 1.17 (95% CI 0.82–1.67) and the HRadjusted for RF was 1.52 (95% CI 1.00–2.30). The association of RF positivity with CVD was even stronger in the anti-CCP–negative patients: HRadjusted 2.09 (95% CI 1.18–3.71). There was no significant interaction (p = 0.098) between anti-CCP and RF.Conclusion.Rather than anti-CCP, presence of RF was associated with CVD in this cohort of patients with RA.
Validation of a Knowledge Transfer Tool According to the OMERACT Filter: Does Web-based Real-time Iterative Calibration Enhance the Evaluation of Bone Marrow Lesions in Hip Osteoarthritis?
Authors: Jaremko Jacob L. , Azmat Omar , Lambert Robert G.W. , Bird Paul , Haugen Ida K. , Jans Lennart , Weber Ulrich , Winn Naomi , Zubler Veronika , Maksymowych Walter P. 
Published: July 2017

Objective.To assess reliability and feasibility of using a Web-based interface and interactive online calibration tool for magnetic resonance imaging (MRI) scoring of bone marrow lesions (BML) in osteoarthritis (OA), applied to the Hip MR Inflammation Scoring System (HIMRISS).Methods.Seven readers new to HIMRISS (3 radiologists, 4 rheumatologists) scored coronal short-tau inversion recovery MRI from a hip OA observational study obtained pre- and 8-week poststeroid injection (n = 40 × 2 scans × 2 hips = 160 hips). By crossover design, Group B (4 readers) scored 20 patients (40 hips) using conventional spreadsheet-based methods and then another 20 using a Web-based interface and an online real-time iterative calibration (RETIC) training module. Group A (3 readers) reversed the order, scoring the first 20 subjects by the new method and the final 20 conventionally. Outcomes included ICC and reader survey.Results.Interobserver reliability for BML status was high by both spreadsheet and Web-based methods (0.84–0.90), regardless of the order in which scoring was performed. Reliability of change scores was moderate and improved with training. Improvement was greater in readers who began with the spreadsheet method and then used the Web-based method than in those who began with the Web-based method, especially at the acetabulum. Readers found Web-based/RETIC scoring more user-friendly and nearly 50% faster than traditional spreadsheet methods.Conclusion.HIMRISS offers reliable BML scoring in OA, whether by conventional spreadsheet-based scoring or by a Web-based interface with interactive feedback. The new method allowed faster readings, provided a consistent training environment that helped inexperienced readers achieve reliability equivalent to that of conventional methods, and was preferred by the readers.
Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review — OMERACT Virtual Special Interest Group
Authors: Cross Marita , Dubouis Ludovic , Mangin Matthieu , Hunter David J. , March Lyn , Hawker Gillian , Guillemin Francis 
Published: July 2017

Objective.Beyond the exacerbation of pain in describing a flare in osteoarthritis (OA), patients and health professionals add other elements that deserve to be fully elucidated, such as effusion, swelling, and mobility limitation. To define and conceptualize the construct flare in OA, the objective was to identify the key variables, or symptoms, that worsen, and to clarify how these variables are described in the literature by patients and clinicians.Methods.A systematic review of the literature was conducted in Medline and PsychINFO. In brief, the search terms used were “osteoarthritis,” “knee,” “hip,” and “flare.” Specific characteristics of included studies were identified, including the type of study design, type of flare assessed, how the flare developed, and what definition of flare was used, including whether the definition was based on qualitative or quantitative analysis.Results.Pain was the major factor in the definition of flare within these studies. Four components of flare were identified: pain, other factors, composite criteria, and global assessment. While the majority of studies reported flare as an increase in pain using standardized outcome measures, only 1 study reported the antecedents and consequences of a pain flare using qualitative methods.Conclusion.The use of flare as an outcome or inclusion criterion in rheumatology trials is a common occurrence; however, this review highlights the wide variation in the definitions of OA flare currently in use and the emphasis on the measurement of pain. This variation in definition does not allow for direct comparison between trials and limits interpretation of evidence.
Mesenchymal Cell–Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes
Authors: Kim Donghyun , Seo Sang-Uk , Zeng Melody Y. , Kim Wan-Uk , Kamada Nobuhiko , Inohara Naohiro , Núñez Gabriel 
Published: July 2017

Abstract
Enteric pathogens including Salmonella enteric serovar Typhimurium can breach the epithelial barrier of the host and spread to systemic tissues. In response to infection, the host activates innate immune receptors via the signaling molecule MyD88, which induces protective inflammatory and antimicrobial responses. Most of these innate immune responses have been studied in hematopoietic cells, but the role of MyD88 signaling in other cell types remains poorly understood. Surprisingly, we found that Dermo1-Cre;Myd88fl/fl mice with mesenchymal cell–specific deficiency of MyD88 were less susceptible to orogastric and i.p. S. Typhimurium infection than their Myd88fl/fl littermates. The reduced susceptibility of Dermo1-Cre;Myd88fl/fl mice to infection was associated with lower loads of S. Typhimurium in the liver and spleen. Mutant analyses revealed that S. Typhimurium employs its virulence type III secretion system 2 to promote its growth through MyD88 signaling pathways in mesenchymal cells. Inflammatory monocytes function as a major cell population for systemic dissemination of S. Typhimurium. Mechanistically, mesenchymal cell–specific MyD88 signaling promoted CCL2 production in the liver and spleen and recruitment of inflammatory monocytes to systemic organs in response to S. Typhimurium infection. Consistently, MyD88 signaling in mesenchymal cells enhanced the number of phagocytes including Ly6ChiLy6G− inflammatory monocytes harboring S. Typhimurium in the liver. These results suggest that S. Typhimurium promotes its systemic growth and dissemination through MyD88 signaling pathways in mesenchymal cells.
CT-guided percutaneous radiofrequency ablation of osteoid osteoma: Our experience in 87 patients
Authors: Chahal Anurag , Rajalakshmi Prathiba , Khan Shah A , Rastogi Shishir , Srivastava Deep N , Gamanagatti Shivanand 
Published: July 2017

Abstract
Purpose: To evaluate the technical and clinical success of radiofrequency ablation of osteoid osteoma and analyze the factors responsible for clinical success. We also tried to investigate the role of follow-up computed tomography (CT) imaging. Materials and Methods: This is a prospective study approved by the institute's ethics committee involving 87 patients with appendicular osteoid osteoma. CT-guided radio frequency ablation was performed using a bipolar ablation system. Patients were followed up over 15.4 (4–24) months for pain, and clinical success/failure was determined using established criteria. Patients with clinical failure were taken for repeat ablation. Follow-up CT was obtained at 6 months and correlated with clinical success. Procedural scans were later reviewed for technical success in a blinded manner and correlated with clinical success along with other imaging and patient characteristics. Results: Mean pre-procedure visual analog scale (VAS) score was 7.0 ± 0.8. Primary success rate after single session was 86.2%(75/87 patients), and overall success rate after one/two sessions was 96.6%(84/87). No major complications were noted. Technical success rate was 89.7%(78/87). All 9 patients who had a suboptimal needle positioning had recurrence where as three patients had recurrence despite technical success. None of the imaging characteristics or history of prior intervention was significantly associated with clinical success. Follow-up CT showed advanced bone healing in 48 lesions, and was confined to the treatment success group. Alternately, minimal/absent bone healing was seen in all (12) patients of primary treatment failure and 27 patients with treatment success. Conclusions: CT-guided percutaneous radio frequency ablation is a safe and highly effective treatment for osteoid osteomas even in recurrent and residual cases. Technical success is the most important parameter affecting the outcome. Post radio frequency ablation CT findings have a good positive but a poor negative predictive value in prognostication.
Multimodality imaging spectrum of complications of horseshoe kidney
Authors: Shah Hardik U , Ojili Vijayanadh 
Published: July 2017

AbstractHorseshoe kidney is the most common congenital renal fusion anomaly with an incidence of 1 in 400–600 individuals. The most common type is fusion at the lower poles seen in greater than 90% of the cases, with the rest depicting fusion at the upper poles, resulting in an inverted horseshoe kidney. Embryologically, there are two theories hypothesizing the genesis of horseshoe kidney – mechanical fusion theory and teratogenic event theory. As an entity, horseshoe kidney is an association of two anatomic anomalies, namely, ectopia and malrotation. It is also associated with other anomalies including vascular, calyceal, and ureteral anomalies. Horseshoe kidney is prone to a number of complications due to its abnormal position as well as due to associated vascular and ureteral anomalies. Complications associated with horseshoe kidney include pelviureteric junction obstruction, renal stones, infection, tumors, and trauma. It can also be associated with abnormalities of cardiovascular, central nervous, musculoskeletal and genitourinary systems, as well as chromosomal abnormalities. Conventional imaging modalities (plain films, intravenous urogram) as well as advanced cross-sectional imaging modalities (ultrasound, computed tomography, and magnetic resonance imaging) play an important role in the evaluation of horseshoe kidney. This article briefly describes the embryology and anatomy of the horseshoe kidney, enumerates appropriate imaging modalities used for its evaluation, and reviews cross-sectional imaging features of associated complications.
Temporal artery biopsies in south-east Scotland: a five-year review
Authors: Gajree S , Borooah S , Dhillon N , Goudie C , smith C , Aspinall P , Dhillon B 
Published: July 2017

Temporal artery biopsy is the gold standard investigation for the diagnosis of giant cell arteritis. The aim of this retrospective study was to investigate the use of temporal artery biopsy in diagnosing giant cell arteritis in southeast Scotland over a five-year period. We aimed to quantify success rates, and predictive factors for a positive biopsy, as well as compare the different specialities performing the biopsies. The data should enable the development of better criteria for referral for investigation of giant cell arteritis. Methods Patients were identified using a database of temporal artery biopsies generated by the pathology department in NHS Lothian (south east Scotland), for all biopsies examined between January 2010 and December 2015. An electronic patient record was used to retrospectively examine the records of patients in the database. Results A total of 715 biopsies were included in the study, of which 250 (35.0%) showed features of giant cell arteritis. The main predictors for a positive biopsy were age at biopsy, specialty performing biopsy, erythrocyte sedimentation rate, jaw claudication/pain, and ophthalmic symptoms. The most important predictor of a positive biopsy was erythrocyte sedimentation rate. The length of biopsy was not found to be a predictor of positive biopsy; however, diameter of biopsy was predictive. Conclusions We have shown that many temporal artery biopsies are negative, and f nding ways to reduce the number of patients unnecessarily undergoing biopsy will be essential in reducing workload and streamlining services. This study demonstrates some key predictive factors for patients with positive biopsies. The study also shows that a large proportion of biopsies taking place do not result in the recommended length of specimen, but this does not necessarily reduce the likelihood of a positive biopsy.
A theory of economic policy lock-in and lock-out via hysteresis: rethinking economists’ approach to economic policy
Authors: Palley Thomas 
Published: July 2017

Abstract
This paper uses hysteresis to develop the concept of policy lock-in and lock-out. Policy changes may near-irrevocably change the economy’s structure, thereby changing the distribution of wealth, income and power. That may lock-in policy by changing the political equilibrium. Exit costs that block policy reversals also cause lock-in. Conventional thinking treats policy as a dial which is adjusted according to the economy’s state. Policy lock-in questions the dial formulation and raises new issues for optimal policy design. It also offers insights into economic and political crisis theory. Policy lock-in is illustrated with examples that include tax policy, government spending, the euro, globalization, and the neoliberal policy experiment.
Improving the inverse modeling of a trace isotope: how precisely can radium-228 fluxes toward the ocean and submarine groundwater discharge be estimated?
Authors: Le Gland Guillaume , Mémery Laurent , Aumont Olivier , Resplandy Laure 
Published: July 2017

Abstract. Radium-228 (228Ra), an almost conservative trace isotope in the ocean, supplied from the continental shelves and removed by a known radioactive decay (T1∕2 = 5. 75 years), can be used as a proxy to constrain shelf fluxes of other trace elements, such as nutrients, iron, or rare earth elements. In this study, we perform inverse modeling of a global 228Ra dataset (including GEOSECS, TTO and GEOTRACES programs, and, for the first time, data from the Arctic and around the Kerguelen Islands) to compute the total 228Ra fluxes toward the ocean, using the ocean circulation obtained from the NEMO 3.6 model with a 2° resolution. We optimized the inverse calculation (source regions, cost function) and find a global estimate of the 228Ra fluxes of 8.01–8. 49 × 1023 atoms yr−1, more precise and around 20 % lower than previous estimates. The largest fluxes are in the western North Atlantic, the western Pacific and the Indian Ocean, with roughly two-thirds in the Indo-Pacific Basin. An estimate in the Arctic Ocean is provided for the first time (0.43–0.50  ×  1023 atoms yr−1). Local misfits between model and data in the Arctic, the Gulf Stream and the Kuroshio regions could result from flaws of the ocean circulation in these regions (resolution, atmospheric forcing). As radium is enriched in groundwater, a large part of the 228Ra shelf sources comes from submarine groundwater discharge (SGD), a major but poorly known pathway for terrestrial mineral elements, including nutrients, to the ocean. In contrast to the 228Ra budget, the global estimate of SGD is rather unconstrained, between 1.3 and 14. 7 × 1013 m3 yr−1, due to high uncertainties on the other sources of 228Ra, especially diffusion from continental shelf sediments. Better precision on SGD cannot be reached by inverse modeling until a proper way to separate the contributions of SGD and diffusive release from sediments at a global scale is found.
Marcel Gauchet e a saída contemporânea da religião
Authors: Lott Henrique Marques 
Published: July 2017

<p>Este artigo procura perquirir sobre a situação atual da saída da religião no âmbito da teoria do filósofo francês Marcel Gauchet. O que se objetiva é uma aproximação compreensiva a alguns conceitos que permeiam seu pensamento acerca do fenômeno religioso. A análise que desenvolvemos está dividida em quatro partes distintas. Na primeira parte explora-se mais especificamente as bases do conceito gauchetiano de religião. Trata-se de um conceito que, como veremos, traz uma concepção que acolhe a ideia de uma religião em estado puro ou em estado de essência. Na segunda parte, nos deteremos na noção de saída da religião em um sentido mais geral do vocabulário de nosso autor, abordando um pouco do processo histórico dessa saída, seus inícios e seus principais desdobramentos. Na terceira parte, dirigimos nossos esforços compreensivos para a situação atual da saída da religião e para as novas configurações que se apresentam como espiritualidades fora da religião. Na quarta e última parte, procuramos fazer uma reflexão sobre a religiosidade contemporânea brasileira a partir da perspectiva teórica aberta pelo filósofo francês. O que é possível entrever no contexto da análise aqui proposta, é que a dinâmica da saída da religião, que nos colocou em conexão direta com uma experiência desencantada de mundo, não elimina a religião e muito menos a fé religiosa. Apesar de delimitar novos papeis para a religião — ao retirá-la da esfera mais estrita do político — a saída da religião não exclui a participação das religiões no campo da esfera pública e da sociedade civil. </p>
Možnosti aplikace konceptu postmateriálního štěpení na substátních úrovních
Authors: Musilová Karolína 
Published: July 2017

The paper deals with the possibility of application of post-material – material cleavage at the local and regional level. Although the concept was originally designed for central level of political system decades ago, it is still relevant for different reasons. Through analysis of current state of research in respective field and existing papers on cleavages at the subnational level, the paper seeks for conditions under which concept of cleavages may be transferred at the subnational levels of governance. The concept of multilevel governance is then used to define specific features of different levels and to prove to possibility of such transfer. The results show the concept may be adapted at local and regional level, however it´s crucial to adjust the selected definition of cleavage, especially in terms of institutional manifestation.
Analysis of admixture proportions in seven geographical regions of the state of Guerrero, Mexico
Authors: Cahua‐Pablo José Ángel , Cruz Miguel , Tello‐Almaguer Pedro Vidal , del Alarcón‐Romero Luz Carmen , Parra Esteban Juan , Villerías‐Salinas Salvador , Valladares‐Salgado Adán , Tello‐Flores Vianet Argelia , Méndez‐Palacios Abigail , Pérez‐Macedonio Claudia Paola , Flores‐Alfaro Eugenia 
Published: July 2017

AbstractObjectiveMexico's current population structure has been defined by admixture between European, Native American, and to some extent African, groups that started in the sixteenth century. The aim of this research was to analyze the relative contributions of these continental population groups to the seven regions of the state of Guerrero, Mexico.MethodsA total of 104 ancestry informative markers were analyzed in 480 unrelated women from the seven regions of the state of Guerrero. The individual ancestry proportions were estimated using the software ADMIXMAP v3.2.ResultsThe relative Native American, European and African ancestral contributions to the whole sample were estimated to be 69%, 27%, and 1.9%, respectively. We observed significant differences in admixture proportions across the regions. The highest average Native American ancestry was found in the Montaña region and the lowest in Costa Grande. Conversely, the highest European contribution was observed in Costa Grande. The highest African contributions were observed in the regions of Costa Chica and Costa Grande.ConclusionsThe genetic structure of the population of Guerrero reflects quite well the historical processes that have occurred in this state. Native American population settlements were mainly in the regions of Montaña, Norte, and Centro, where the highest indigenous genetic contribution is observed today. European settlers came from the center of the state to regions with significant agricultural and mining activities. The highest African contributions are observed in coastal regions, in agreement with historical evidence about slave trade routes in the Americas.