bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Role of PD-L1 in Malignant Solid Tumors: A Meta-Analysis
Authors: Pyo Jung-Soo , Kang Guhyun , Kim Jung Yeon 
Published: March 2017

Purpose The aim of this study was to elucidate the rates and prognostic roles of programmed cell death ligand 1 (PD-L1) immunohistochemical (IHC) expression in various malignant tumors through a systematic review and meta-analysis. Method The current study included 16,176 patients from 97 eligible studies. We investigated PD-L1 expression and its correlation with survival rate in various malignant tumors. Results The estimated rate of PD-L1 IHC expression was 0.449 (95% confidence interval [CI] 0.404-0.495). The highest and lowest PD-L1 expression levels were found in thyroid cancer (0.829, 95% CI 0.781-0.868) and small-cell neuroendocrine carcinoma (0.005, 95% CI 0.000-0.080), respectively. PD-L1 expression was significantly correlated with poorer overall survival and disease-free survival rates (hazard ratios 1.276, 95% CI 1.097-1.486 and 1.304, 95% CI 1.034-1.644, respectively). However, PD-L1 IHC expression was significantly correlated with worse overall survival rates in patients with esophageal cancer and renal cell carcinoma and with worse disease-free survival rates in patients with colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. Conclusions Our results show that PD-L1 expression rates and the correlations with survival varied between tumor types. Detailed evaluation criteria for PD-L1 will have to be standardized before application to specific tumor types.
Prostate Volume Index Stratified Prostate Cancer Risk in Patients Elected to a First Random Biopsy Set
Authors: Porcaro Antonio B. , Corsi Paolo , de Luyk Nicolò , Sebben Marco , Tafuri Alessandro , Bizzotto Leonardo , Cacciamani Giovanni , De Marchi Davide , Processali Tania , Mattevi Daniele , Novella Giovanni , Cerruto Maria A. , Brunelli Matteo , Siracusano Salvatore , Artibani Walter 
Published: March 2017

Objective To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set. Methods The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1. The multivariate logistic regression model investigated clinical factors with dichotomized PVI associating with PCA. Results The detection rate of PCA was 49%. The dichotomized PVI >1 stratified PCA risk (odds ratio [OR] 0.455; p<0.0001) beyond age (OR 1.062; p<0.0001), PSA (OR 1.167; p<0.0001), PV (OR 0.957; p<0.0001), and abnormal digital rectal examination (OR 2.094; p<0.0001). The goodness of fit statistics assessed model efficacy. Conclusions A large cohort of patients elected to a first random biopsy set had PCA risk stratified by dichotomized PVI beyond other clinical independent factors. Confirmatory studies are required.
The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model
Authors: Aghayeva Afag , Benlice Cigdem , Bilgin Ismail Ahmet , Atukeren Pinar , Dogusoy Gulen , Demir Figen , Atasoy Deniz , Baca Bilgi 
Published: March 2017

Introduction Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model. Methods Sixty Wistar albino rats were employed in the study. Sigmoid resection and end-to-end colorectal anastomosis was performed in all rats. Group 1 rats underwent the surgical procedure alone, while group 2 rats were given hyperthermic intraperitoneal lavage with heated saline following surgery. Groups 3, 4, 5, and 6 had surgery with concomitant HIPEC treatment with mitomycin C, cisplatin, oxaliplatin, and doxorubicin, respectively. Anastomotic bursting pressures and hydroxyproline levels were evaluated. Results Regarding the hydroxyproline levels, groups 1 and 2 showed significantly higher values than other groups (p<0.001). However, there was no significant difference between the HIPEC treatment groups (groups 3, 4, 5, and 6) (p>0.05). When groups were compared regarding bursting pressure values, no significant differences were observed (p = 0.81). Conclusions This study demonstrated that the HIPEC procedure with mitomycin C, cisplatin, oxaliplatin and doxorubicin had negative effects on hydroxyproline levels, but had no detrimental effect on anastomotic bursting pressure in a rat model.
Changes in Mortality and Incidence of Prostate Cancer by Risk Class in Different Periods in Italy: The Possible Effects of PSA Spread
Authors: Vicentini Massimo , Sacchettini Claudio , Trama Annalisa , Nicolai Nicola , Gatta Gemma , Botta Laura , Valdagni Riccardo , Giorgi Rossi Paolo ,   Prostate Cancer High-Resolution Study Working Group, Pannozzo Fabio , Contiero Paolo , Fusco Mario , Lodde Michele , Mazzoleni Guido , Piffer Silvano , Tumino Rosario , Puppo Antonella , Seeber Andreas , Mangone Lucia 
Published: March 2017

Purpose In Italy, the spread of prostate-specific antigen (PSA) testing varies in different areas. A peak of incidence was reached in 2003-2004 in some areas, while in others the incidence is still increasing. Mortality has declined since 1999 in some areas, while it remains stable in others. We compared mortality and the risk of advanced cancer over 2 periods (1996-1998; 2005-2007) and by geographic area characterized by a different spread of PSA, to understand the possible impact of PSA on the epidemiology of prostate cancer. Methods In 8 Italian Cancer Registries (CRs), 4,632 cases diagnosed over 2 periods, 1996-1998 and 2005-2007, were sampled to assess risk class. The CRs were classified into late and early phase of PSA testing depending on whether an incidence peak had been reached by 2008. Incidence by risk class was estimated based on overall incidence in each CR and on risk class distribution in the sample. We calculated standardized mortality (MRR) and risk class-specific incidence rate ratios (IRR) to compare the 2 periods. Results Incidence increased from 1996-1998 to 2005-2007 (IRR 1.5; 95% CI 1.4, 1.6). High-risk and metastatic cancer incidence decreased only in late-phase areas (IRR 0.78; 95% CI 0.69, 0.88; and 0.40; 95% CI 0.30, 0.54, respectively), while in early-phase areas, incidence remained virtually stable (IRR 1.2; 95% CI 1.0, 1.4; and 0.77; 95% CI 0.59, 1.0, respectively). Mortality decreased only in late-phase areas (MRR 0.81; 95% CI 0.85, 0.97; vs 1.1; 95% CI 0.92, 1.2) in early-phase areas. Conclusions Mortality reduction and a decrease in high-risk and metastatic cases occurred simultaneously only in areas in late phase of PSA spread.
Treatment of Multiple Synchronous Misdiagnosed Renal Cell Cancers in A Young Patient Affected by A “De Novo” Von Hippel-Lindau Syndrome
Authors: Allasia Marco , Battaglia Antonino , Pasini Barbara , Gazzera Carlo , Calandri Marco , Bosio Andrea , Gontero Paolo , Destefanis Paolo 
Published: March 2017

Introduction Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited syndrome occurring in one out of 36,000 live births. Diagnosis could be a challenge in patients with no familial VHL history. Renal cancer (RCC) represents one of the most important manifestations. RCC is usually recurrent and multifocal. Actually treating RCC in VHL patients represent a clinical dilemma: the oncological outcomes must be balanced against renal function preservation. Case Presentation A young man with a negative familial history was referred to our department with seven misdiagnosed renal masses. VHL disease was determined through genetic test. The multiple RCCs were treated by surgery and percutaneous thermal ablation by radiofrequency ablation (RFA) with complete control of RCC and no impairment of renal function. Conclusions This case history confirms that VHL disease has to be suspected in young patients with evidence of synchronous multiple renal masses and in presence of specific clinical criteria. RFA appears to be safe in terms of oncological radicalism and in renal function preservation. In hereditary RCC, we should purpose, whenever it is possible, minimally invasive treatment in terms of low hospital stay and a minimal loss of renal tissue.
La ideación del territorio de Barcelona a través de su representación
Authors: Santamaria Varas Mar , Martinez-Diez Pablo 
Published: March 2017

El objetivo de este artículo es describir cuáles han sido las herramientas hasta ahora determinantes en el planeamiento del Área Metropolitana para luego comprender el estado actual de la técnica de cara a vislumbrar las futuras transformaciones. A diferencia de otros trabajos que exponen la historia de Barcelona (Solà-Morales, 2008 y Espuche y Guàrdia, 1986), o bien tratan de extraer conclusiones acerca del llamado “Modelo Barcelona” (Montaner, Álvarez y Muxí 2012), este artículo se apoya en la hipótesis de que las herramientas de representación condicionan la mirada y, por lo tanto, el proyecto objeto de éstas tal y como afirma Corner (1999). A través del análisis y la comparación de diversas representaciones gráficas, se centra la mirada sobre unos pocos momentos en la historia del territorio metropolitano de Barcelona en los cuales el planeamiento urbano ha sido influenciado profundamente por las herramientas de diseño empleadas, desde la topografía al Big data.
This paper aims to describe what tools have been decisive so far in the urban planning of the Barcelona Metropolitan Area with the ultimate goal of understanding the current state of the art and anticipate future transformations. Unlike other papers describing the history of Barcelona (Solà-Morales, 2008 and Espuche and Watchkeeping, 1986) or drawing conclusions about the so-called "Barcelona model" (Montaner, Alvarez and Muxí, 2012), this article is based on the hypothesis that representation tools condition the way we see the world and so the resulting project, as Corner states (1999). By means of analysis and comparison of various cartographies, this paper reviews some moments in the history of Barcelona Metropolitan Area when urban planning has been deeply influenced by design tools, from traditional surveys to Big Data.
L'objectiu d'aquest article és descriure quines han estat les eines fins ara determinants en el planejament de l'Àrea Metropolitana per després comprendre l'estat actual de la tècnica de cara a albirar les futures transformacions. A diferència d'altres treballs que exposen la història de Barcelona (Solà-Morales, 2008 i Espuche i Guàrdia, 1986), o bé tracten d'extreure conclusions sobre l'anomenat "Model Barcelona" (Montaner, Álvarez i Muxí, 2012), aquest article es dóna suport a la hipòtesi que les eines de representació condicionen la mirada i, per tant, el projecte objecte d'aquestes tal com afirma Corner (1999). A través de l'anàlisi i la comparació de diverses representacions gràfiques, se centra la mirada sobre uns pocs moments en la història del territori metropolità de Barcelona en els quals el planejament urbà ha estat influenciat profundament per les eines de disseny emprades, des de la topografia al Big data.
Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer
Authors: Garcia Elizabeth P. , Minkovsky Alissa , Jia Yonghui , Ducar Matthew D. , Shivdasani Priyanka , Gong Xin , Ligon Azra H. , Sholl Lynette M. , Kuo Frank C. , MacConaill Laura E. , Lindeman Neal I , Dong Fei 
Published: March 2017

Context.—
The analysis of somatic mutations across multiple genes in cancer specimens may be used to aid clinical decision making. The analytical validation of targeted next-generation sequencing panels is important to assess accuracy and limitations.

Objective.—
To report the development and validation of OncoPanel, a custom targeted next-generation sequencing assay for cancer.

Design.—
OncoPanel was designed for the detection of single-nucleotide variants, insertions and deletions, copy number alterations, and structural variants across 282 genes with evidence as drivers of cancer biology. We implemented a validation strategy using formalin-fixed, paraffin-embedded, fresh or frozen samples compared with results obtained by clinically validated orthogonal technologies.

Results.—
OncoPanel achieved 98% sensitivity and 100% specificity for the detection of single-nucleotide variants, and 84% sensitivity and 100% specificity for the detection of insertions and deletions compared with single-gene assays and mass spectrometry–based genotyping. Copy number detection achieved 86% sensitivity and 98% specificity compared with array comparative genomic hybridization. The sensitivity of structural variant detection was 74% compared with karyotype, fluorescence in situ hybridization, and polymerase chain reaction. Sensitivity was affected by inconsistency in the detection of FLT3 and NPM1 alterations and IGH rearrangements due to design limitations. Limit of detection studies demonstrated 98.4% concordance across triplicate runs for variants with allele fraction greater than 0.1 and at least 50× coverage.

Conclusions.—
The analytical validation of OncoPanel demonstrates the ability of targeted next-generation sequencing to detect multiple types of genetic alterations across a panel of genes implicated in cancer biology.
Un oubli mémorable. Les journaux québécois face à la demande sociale de reconnaissance du génocide arménien par la communauté arménienne québécoise (1965-1998)
Authors: Chabot Joceline , Kasparian Sylvia , Thériault Christine 
Published: March 2017

Depuis plus d’un demi-siècle, la communauté arménienne en diaspora lutte pour la reconnaissance du génocide commis contre les Arméniens par les autorités de l’Empire Ottoman en 1915-1916. Ce crime est l’objet d’un oubli institutionnalisé par le déni turc et l’indifférence d’une partie de la communauté internationale. C’est dans ce cadre que se situe notre article qui interroge la dynamique politique et symbolique mise en oeuvre dans l’espace médiatique québécois d’une demande de reconnaissance du génocide arménien par la communauté arménienne québécoise. Plus précisément, nous analysons l’inscription de la mémoire du génocide arménien et de sa représentation dans deux journaux québécois Le Devoir et La Presse, de son émergence dans les années 1960 jusqu’à la fin des années 1990. Le recours aux outils informatisés d’analyse de données textuelles pour l’analyse exploratoire et descriptive de notre corpus de presse représente l’un des aspects novateurs de notre recherche.
Module NooJ du français. Traitement automatique de corpus de français parlé
régional
Authors: Chevalier Gisèle , Kasparian Sylvia 
Published: March 2017

Le traitement automatique des corpus oraux est en plein essor. L’intérêt gagne du
terrain, mais les outils restent rares. Dans notre article, nous présentons un outil que
nous avons développé pour l’analyse de corpus oraux spontanés en français acadien. Ces
variétés de français parlées dans les Provinces maritimes du Canada ont trois niveaux de
traits caractéristiques : elles sont orales, régionales et mixtes. Notre défi fut celui
d’adapter et de créer un module NooJ acadien qui permette le traitement d’un corpus
présentant de telles spécificités. Nous présentons ici trois solutions développées avec
NooJ : 1) la configuration d’un dictionnaire qui permette la reconnaissance
orthographique et lexicale de mots présentant des traits à la fois de français standard,
d’acadien traditionnel et de l’anglais ou du vernaculaire; 2) les grammaires développées
pour l’analyse des traits morphologiques de la flexion nominale et verbale; 3) un graphe de
désambiguïsation pour a, qui représente non seulement la 3e personne du
singulier du présent du verbe avoir, mais aussi la 3e personne du pronom
personnel féminin singulier en français acadien.
Recommended Augmentative and Alternative Communication Competencies for Special Education Teachers
Authors: Da Fonte M. Alexandra , Boesch Miriam C. 
Published: March 2017

Abstract
Empirical evidence supports the notion of special education teachers receiving limited pre-service training in augmentative and alternative communication (AAC). This lack of training is not only evident in the United States but in other countries such as United Kingdom, India, and Israel. Yet the teaching demands for the use of AAC are increasing as more students with complex communication needs are entering the school systems. As a result, this paper outlines four special education teacher competencies needed to effectively address the communication needs of these students. The four competencies consist of the needs for training in the areas of (1) communication development and communicative competencies, (2) teamwork and collaborative practices, (3) role and functions of AAC systems, and (4) AAC assessment and instructional strategies. These competencies are aligned to the standards from the Council for Exceptional Children and the literature available on AAC training. Evidence suggests there is a lack of training for special education teachers and other professionals in this area and limited research to guide teacher preparation programs.
Effect of Amharic Letter Acquisition and Fluency Instruction on the Reading Achievement of Ethiopian Students at Risk for Reading Difficulties
Authors: Abdi Yirgashewa Bekele , Therrien William J. 
Published: March 2017

Abstract
This study took place in Addis Ababa, Ethiopia and examined the impact of explicit instruction and fluency practice of letter/sound combinations on reading Amharic letters and words. First grade students at risk for reading difficulties were assigned via stratified random assignment to treatment or control condition. Students in the treatment group received explicit instruction and fluency practice on grade one Amharic letters, two times a week for 18 weeks for 36 sessions. Students in the control condition received typical Amharic reading instruction. Results indicate that students in the treatment condition significantly outperformed students in control on letter sound identification and word reading fluency.
Building the Oral Language of Young Hispanic Children Through Interactive Read Alouds and Vocabulary Games at Preschool and at Home
Authors: Baker Doris Luft , Mogna Vivianne , Rodriguez Sandra , Farmer Dylan , Yovanoff Paul 
Published: March 2017

AbstractWe conducted two studies to examine the effects of an interactive read aloud and vocabulary intervention on the vocabulary knowledge of Spanish-speaking preschoolers living in the U.S. In Study 1, 68 children (n = 34 in the treatment group) and 6 parents in the treatment group received the intervention in Spanish at home, and in Spanish and English in the preschool. Results indicated a significant effect of the intervention on children's receptive and expressive vocabulary knowledge in Spanish favoring the treatment group. Effect sizes were moderate to large. English outcomes were significant for the treatment group only on the receptive vocabulary measure. Children who participated in the Home plus Preschool intervention (n = 6) made significant gains on their Spanish vocabulary knowledge with large effect sizes. In Study 2 we conducted a single subject design study with four preschool children and their mothers. The intervention was provided at home. Results indicated a change from baseline to maintenance for all four children on their Spanish vocabulary knowledge. Parents in both studies saw important changes in their children's engagement in read alouds as well as in their children's communication skills.
A Promising Practice: School-Based Mindfulness-Based Stress Reduction for Children with Disabilities
Authors: Fuchs Wendy W. , Mundschenk Nancy J. , Groark Brian 
Published: March 2017

Abstract
Adults and children around the world are experiencing unhealthy levels of stress. More specifically, the stress levels that children report can have detrimental effects on their social-emotional, physical and academic well-being. Schools are in a unique position to not only address the causes of stress in children's lives, but to also provide strategies to reduce stress. Mindfulness-Based Stress Reduction (MBSR) is one approach that schools can use to teach children how to acknowledge and deal with everyday stressors. This article aims to provide a definition of stress, describe MBSR, and provide a review of the current literature on MBSR studies with children. Additionally, the authors suggest implications for school-based mindfulness approaches to reduce the stress of children with disabilities, and recommendations for future research.
Examining Self-Monitoring Interventions for Academic Support of Students with Emotional and Behavioral Disorders
Authors: Hunter William , Williamson Robert L , Jasper Andrea D , Casey Laura Baylot , Smith Clinton 
Published: March 2017

AbstractResearchers have found that English teachers in the United States of America (USA) perceive providing writing instruction to students with emotional behavioral disorders (EBD) as a difficult task. This could be associated with the fact that students with EBD often work below skill level in the content area of writing compared to same age peers. Researchers continue to investigate interventions to increase academic outcomes for students with EBD. Utilizing a single case design, three middle school students with EBD were observed in a self-contained classroom to determine the effects of a traditional and technology based self-monitoring intervention focused on decreasing student off-task behaviors while increasing scores on writing assignments. The study took place in an urban school district within the Southeastern region of the USA. Results indicated that the first two intervention phases were equally as effective at reducing off-task behaviors. Additionally, the third intervention phase led to decreased off-task behaviors and increased writing scores for all students compared to the previous two phases. Social validity assessments indicated that the self-monitoring interventions were useful and relevant for teachers and students with EBD in the self-contained setting. Implications for teachers and educational researchers are discussed within this article.
Increased water yield due to the hemlock woolly adelgid infestation in New England
Authors: Kim Jihyun , Hwang Taehee , Schaaf Crystal L. , Orwig David A. , Boose Emery , Munger J. William 
Published: March 2017

AbstractOver the past few decades, a hemlock woolly adelgid (HWA) infestation has significantly affected eastern hemlock (Tsuga canadensis) in the eastern U.S., and warmer winters are expected to promote a continued northward expansion in the future. Here we report a water yield increase due to the HWA infestation in New England, U.S. Since the first observation in 2002, peak growing season evapotranspiration over a hemlock‐dominated area has decreased by 24–37% in 2012 and 2013. Over the same time period, the water yield from the study catchment significantly increased as compared to an adjacent catchment with less hemlock cover. The net increase was estimated to be as much as 15.6% of annual water yield in 2014 based on an ecohydrological modeling analysis. This study indicates that the ongoing hemlock decline is also largely altering hydrological regimes in the northeastern U.S.