bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study
Authors: Duan Lian , Wei Ling , Tian Yanghua , Zhang Zhengshan , Hu Panpan , Wei Qiang , Liu Sugang , Zhang Jun , Wang Yuyang , Li Desheng , Yang Weizhong , Zong Rui , Xian Peng , Han Cong , Bao Xiangyang , Zhao Feng , Feng Jie , Liu Wei , Cao Wuchun , Zhou Guoping , Zhu Chunyan , Yu Fengqiong , Yang Weimin , Meng Yu , Wang Jingye , Chen Xianwen , Wang Yu , Shen Bing , Zhao Bing , Wan Jinghai , Zhang Fengyu , Zhao Gang , Xu Aimin , Zhang Xuejun , Liu Jianjun , Zuo Xianbo , Wang Kai 
Published: December 2017

Background and Purpose—
Moyamoya disease (MMD) is a rare cerebral vasculopathy characterized by bilateral internal carotid artery stenosis and often leads to stroke in children or young adults. Although familial inheritance is well recognized, the genetic basis of MMD remains poorly understood.

Methods—
A 2-stage genome-wide association study was conducted involving 1492 cases and 5084 controls. In the discovery stage, logistic regression was used to test associations, and imputation was conducted based on genotyped single-nucleotide polymorphisms (SNPs). In the validation stage, the top significant SNPs were again genotyped in an independent cohort. Fixed-effects inverse variance-weighted meta-analysis was used in the combined discovery and validation samples. Furthermore, association analysis was conducted in subgroups using patient clinical data.

Results—

The study identified 10 novel risk loci with genome-wide significance (
P
<5×10
−8
) and confirmed a previously reported locus on 17q25. No significant SNP showed evidence of heterogeneity between the 2 stages. Cumulatively, these SNPs explained 14.76% of disease risk variance—a substantial proportion of the 39.02% of risk variance explained by all genome-wide genotyped SNPs. One SNP, rs9916351 in
RNF213
(
P
combined
=4.57×10
−54
; odds ratio, 1.96), showed a stronger genetic effect on early-onset than late-onset MMD (
P
=0.003). Two novel SNPs in genes regulating homocysteine metabolism, rs9651118 in
MTHFR
(
P
combined
=2.49×10
−19
; odds ratio, 0.65) and rs117353193 in
TCN2
(
P
combined
=6.15×10
−13
; odds ratio, 1.43), were associated with high-serum homocysteine in MMD cases. Additionally, another SNP associated with MMD (rs2107595 in
HDAC9
;
P
combined
=1.49×10
−29
; odds ratio, 1.64) was previously implicated in large-vessel disease. Tissue enrichment analysis showed that the genes of associated loci were highly expressed in the immune system (false discovery rate, <0.05).

Conclusions—
This study identifies several novel susceptibility genes for MMD. The association with homocysteine metabolism and the immune system enrichment of susceptibility gene expression suggest that therapeutic interventions targeting these pathways may be effective approaches for MMD treatment.
Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke
Authors: Wang Aili , Zhong Chongke , Zhu Zhengbao , Xu Tian , Peng Yanbo , Xu Tan , Peng Hao , Chen Chung-Shiuan , Wang Jinchao , Ju Zhong , Li Qunwei , Geng Deqin , Sun Yingxian , Zhang Jianhui , Yuan Xiaodong , Chen Jing , Zhang Yonghong , He Jiang 
Published: December 2017

Background and Purpose—
Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke.

Methods—
Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, ≥3) at 3 months after stroke.

Results—

Compared with the lowest quartile of galectin-3, multivariate adjusted odds ratios (95% confidence intervals) for the highest quartile of galectin-3 were 1.55 (1.15–2.09) for composite outcome, 2.10 (0.89–4.95) for death, and 1.43 (1.05–1.93) for major disability. The addition of galectin-3 to the conventional risk factors significantly improved prediction of the combined outcome of death or major disability in patients with ischemic stroke (net reclassification index, 18.9%;
P
<0.001; integrated discrimination improvement, 0.4%;
P
=0.001).

Conclusions—
Higher levels of serum galectin-3 were independently associated with increased risk of death or major disability after stroke onset, suggesting that galectin-3 may have prognostic value in poor outcomes of ischemic stroke.
Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging
Authors: Culp-Hill Rachel , Zheng Connie , Reisz Julie A. , Smith Keith , Rachubinski Angela , Nemkov Travis , Butcher Eric , Granrath Ross , Hansen Kirk C. , Espinosa Joaquín M. , D’Alessandro Angelo 
Published: December 2017

Key PointsThe red blood cell metabolic signature of Down syndrome is identified Trisomy 21 impacts red blood cell redox, amino acid, purine, and bile acid metabolism in an age- and sex-dependent fashion.
Pilot Feasibility Study of an Oncology Financial Navigation Program
Authors: Shankaran Veena , Leahy Tony , Steelquist Jordan , Watabayashi Kate , Linden Hannah , Ramsey Scott , Schwartz Naomi , Kreizenbeck Karma , Nelson Judy , Balch Alan , Singleton Erin , Gallagher Kathleen , Overstreet Karen 
Published: December 2017

Background: Few studies have reported on interventions to alleviate financial toxicity in patients with cancer. We developed a financial navigation program in collaboration with our partners, Consumer Education and Training Services (CENTS) and Patient Advocate Foundation (PAF), to improve patient knowledge about treatment costs, provide financial counseling, and to help manage out-of-pocket expenses. We conducted a pilot study to assess the feasibility and impact of this program. Methods: Patients with cancer received a financial education course followed by monthly contact with a CENTS financial counselor and a PAF case manager for 6 months. We measured program adherence, self-reported financial burden and anxiety, program satisfaction, and type of assistance provided. Results: Thirty-four patients (median age, 60.5 years) were consented (85% white and 50% commercially insured). Debt, income declines, and loans were reported by 55%, 55%, and 30% of patients, respectively. CENTS counselors assisted most often with budgeting, retirement planning, and medical bill questions. PAF case managers assisted with applications for appropriate insurance coverage, cost of living issues (eg, housing, transportation), and disability applications. High financial burden and anxiety about costs (4 or 5 on a Likert scale) were reported at baseline by 37% and 47% of patients, respectively. Anxiety about costs decreased over time in 33% of patients, whereas self-reported financial burden did not substantially change. Conclusion: Implementing an oncology financial navigation program is feasible, provides concrete assistance in navigating the cost of care, and mitigates anxiety about costs in a subset of patients. Future work will focus on measuring the program’s impact on financial and clinical outcomes.
On-Board Oxygen Generation Using High Performance Molecular Sieve
Authors: Bhat Ajaz A. , Mang H. , S. Rajkumar , Kotresh T. M. , Singh U. K. 
Published: December 2017

<p class="p1">The majority of high performance combat aircrafts presently being operated by Indian air Force are fitted with conventional oxygen systems in which a replenishable store of oxygen is carried, most often as liquid oxygen and the flow of gas to each crew member is controlled by an individual pressure demand regulator in which the oxygen is diluted with cabin air to provide breathing gas.Moreover, in-flight refueling capability of present generation fighter aircraft has made it possible to fly for long durations (6 to 8 hours). In such case, the oxygen source becomes one of the limiting factors. In order to meet this requirement, a large supply of Gaseous Oxygen (GASOX) or Liquid Oxygen (LOX) have proven to be a costly affair and the Onboard Oxygen Generating System (OBOGS) has become a very convenient and attractive proposal. The OBOGS employs molecular sieves to adsorb nitrogen from engine bleed air using pressure swing adsorption (PSA) technique, wherein two molecular sieve beds are continuously cycled between steps of pressurization (adsorption) and depressurization (desorption) to generate oxygen enriched breathing gas for aircrew. This paper describes the design of OBOGS using high performance Lithium based Low Silica X-type (Li-LSX) molecular sieves and its performance characteristics. It consists of two Zeolite beds filled with Li-LSX material which adsorbs nitrogen fromengine bleed air tapped from Environmental Control System pipe line. The two beds are cycled by a 5/2 way solenoid valve. The input air is supplied to the solenoid valve through a coalescent filter to reduce moisture from it and a pressure regulator is fitted at the upstream of solenoid valve to regulate the system pressure. The experimental setup for evaluation of OBOGS is also discussed. The OBOGS, presented in this paper, meets all the performance requirements as specified in MIL-C-85521 (AS).<span class="Apple-converted-space"> </span></p>
Biosorption of nickel using mixed cultures of Pseudomonas aeruginosa and Bacillus subtilis
Authors: Uthra K. , Kadirvelu K. 
Published: December 2017

<p class="p1"><span class="s1"> </span>Biosorption of Ni(II) was investigated in this study using dead biomass of gram positive (<strong><em>Bacillus subtilis</em></strong>) and gram negative (<strong><em>Pseudomonas aeruginosa</em></strong>).The effects of pH, initial adsorbent dosage, initial metal ion concentration, contact time and temperature were studied in batch experiment. A contact time of 40 min, pH 5.0 and temperature 30<span class="s2">o</span>C were found to be optimum. Nickel removal decreased from 77 to 45% as the concentration increased from 50 to 250 mg/L. The Ni(II) removal increased from 45 to 75% as adsorbent dose increased from 0.25 to 1.5 g/L. The Langmuir and freundlich models for dynamics of metal of metal ion uptake proposed in this work fit the experimental data reasonably well. The adsorption capacity (Q<span class="s2">o</span>) calculated from Langmuir isotherm was 89.08 mg for Ni (II).<span class="Apple-converted-space"> </span></p>
HeW: AHash Function based on Lightweight Block Cipher FeW
Authors: Kumar Manoj , Dey Dhananjoy , Pal Saibal K , Panigrahi Anupama 
Published: December 2017

<p class="p1">A new hash function <em>HeW: </em>A hash function based on light weight block cipher <em>FeW </em>is proposed in this paper. The compression function of <em>HeW </em>is based on block cipher <em>FeW</em>. It is believed that key expansion algorithm of block cipher slows down the performance of the overlying hash function. Thereby, block ciphers become a less favourable choice to design a compression function. As a countermeasure, we cut down the key size of <em>FeW </em>from 80-bit to 64-bit and provide a secure and efficient key expansion algorithm for the modified key size. <em>FeW </em>based compression function plays a vital role to enhance the efficiency of <em>HeW</em>. We test the hash output for randomness using the NIST statistical test suite and test the avalanche effect, bit variance and near collision resistance. We also give the security estimates of <em>HeW </em>against differential cryptanalysis, length extension attack, slide attack and rotational distinguisher.<span class="Apple-converted-space"> </span></p>
Mobile learning in nursing "m-learning"<p>Hemşirelikte mobil öğrenme “m-öğrenme”
Authors: Şahin Gül , Başak Tülay 
Published: December 2017

Along with the change in information and communication technology, learning methods are also changing. One of the new and fastest growing learning models is m-learning. The m-learning is often defined as a learning environment in which students and instructors can access learning system over wireless network at anytime, anywhere using mobile devices. According to Koole's definition, m-learning; "Is a process of interaction of mobile technologies, learning capacities, and social aspects of the learners”. Use of m-learning in nursing education is increasing day by day. It’s known that these technologies are used in nursing education in many countries, although there is no clear information about the number of schools that use mobile devices in nursing education. M-learning in nursing education; supports learning, provides up-to-date accurate information and has important information potential such as patient safety, support for evidence based practice, development of decision-support systems. Extended English abstract is in the end of Full Text PDF (TURKISH) file.ÖzetBilgi ve iletişim teknolojisindeki değişimle birlikte öğrenme yöntemleri de değişmektedir. Yeni ve çok hızlı gelişen öğrenme modellerinden biri de m-öğrenmedir. M-öğrenme; genellikle öğrencilerin ve eğitmenlerin herhangi bir yerde, herhangi bir zamanda, mobil cihazları kullanarak kablosuz ağ üzerinden öğrenme sistemine erişebilecekleri öğrenme ortamı olarak tanımlanmaktır. Koole'ye göre ise m-öğrenme; “mobil teknolojilerin etkileşiminden, öğrenme kapasitelerinden ve öğrenmenin sosyal yönlerinden oluşan bir süreçtir”. Bu eğitim modelinin; her zaman, her yerde, eğitimde fırsat eşitliğini artırma, formal, informal ve non-formal öğrenme çevrelerinde kesintisiz öğrenmeye olanak sağlama, bireyselleştirilmiş öğrenmeyi kolaylaştırma gibi birçok avantajı bulunmaktadır. Bu nedenle, hemşirelik eğitiminde de kullanımı gün geçtikçe artmaktadır. Hemşirelik eğitiminde mobil cihazları kullanan okulların sayısıyla ilgili açıklayıcı bir bilgi olmasa da, birçok ülkede hemşirelik eğitiminde bu teknolojilerin kullanıldığı bilinmektedir. Hemşirelik eğitiminde m-öğrenme; öğrenmeyi destekler, güncel, doğru bilginin kullanılmasını sağlar ve hasta güvenliğini sağlama, kanıta dayalı uygulamaları destekleme, karar-destek sistemlerinin geliştirilmesi gibi önemli bilgi potansiyeline sahiptir.
Analysis of Injection Systems Types Used in Agricultural Machines
Authors: Juściński Sławomir , Piekarski Wiesław , Chomik Zdzisław 
Published: December 2017

Abstract
The paper presents analysis of the processes taking place in fuel systems which lead to damage of injection devices in farm machines. The most frequent reasons of failure of traditional injection systems and Common Rail high pressure systems which are caused inter alia by an improper quality of diesel oil were described and discussed. Microscopic tests of the surface of worn plungers of the plunger and barrel assemby of Motorpal injection pumps used in Zetor tractors were carried out. Types of damage to elements of the injection pump and electromagnetic injectors used in Common Rail systems CP4 type based on the tests on the group of 126 on-site repairs were assessed. Repairs were made in the repair centres in Podkarpackie Voivodeship and centres dealing with repair of injection systems. Metallographic tests were carried out in the Laboratory of Materials of Rzeszow University of Technology with the use of electrone scanning microscope Hitachi S-3400N.
A note on the range of vector measures
Authors: Urbinati Niccolò , Weber Hans 
Published: December 2017

Abstract
We give another proof for Kluvanek and Knowles’ characterization of Liapounoff measures [KLUVANEK, I.—KNOWLES, G.: Vector Measures and Control Systems. North-Holland Mathematics Studies 20, Amsterdam, 1976] and of the fact that the range of an exhaustive measure with values in a complete locally convex space is relatively weakly compact.
Monotonicity and total boundedness in spaces of “measurable” functions
Authors: Caponetti Diana , Trombetta Alessandro , Trombetta Giulio 
Published: December 2017

Abstract
We define and study the moduli d(x, 𝓐, D) and i(x, 𝓐,D) related to monotonicity of a given function x of the space L
0(Ω) of real-valued “measurable” functions defined on a linearly ordered set Ω. We extend the definitions to subsets X of L
0(Ω), and we use the obtained quantities, d(X) and i(X), to estimate the Hausdorff measure of noncompactness γ(X) of X. Compactness criteria, in special cases, are obtained.
On the lack of equi-measurability for certain sets of Lebesgue-measurable functions
Authors: Tavernise Marianna , Trombetta Alessandro , Trombetta Giulio 
Published: December 2017

Abstract
Let Ω be a Lebesgue-measurable set in ℝ
n
of finite positive Lebesgue measure. In this note we calculate the lack of equi-measurability of the set Kc
(Ω), c > 0, of all Lebesgue-measurable functions f : Ω → ℝ such that 0 ≤ f ≤ c, a.e. on Ω. From our result we repair a gap in the Example 2.3 of the paper [APPELL, J.—DE PASCALE, E.: Su alcuni parametri connessi con la misura di non compattezza di Hausdorff in spazi di funzioni misurabili, Boll. Un. Mat. Ital. B (6) 3 (1984), 497–515].
Crystal structure of bis(μ2-methanolato-κ2
O:O)-bis(methanol-κ1
O)-bis{3-((4-methoxy-2-oxidobenzylidene)amino)-2-oxo-2H-chromen-4-olato-κ3
O,O′,N}dichromium(III), C38H36Cr2N2O14
Authors: Jia Hao-Ran , Li Jing , Sun Yin-Xia 
Published: December 2017

Abstract
C38H36Cr2N2O14, triclinic, P1̄, a = 8.2863(13) Å, b = 10.4324(13) Å, c = 12.152(3) Å, α = 113.420(13)°, β = 93.326(13)°, γ = 107.857(12)°, Z = 1, V = 897.7(2) Å3, R
gt(F) = 0.0454, wR
ref(F
2) = 0.1112, T = 293(2) K.
Hybrid ANN optimized artificial fish swarm algorithm based classifier for classification of suspicious lesions in breast DCE-MRI
Authors: Janaki Sathya D , Geetha K 
Published: December 2017

Abstract
Automatic mass or lesion classification systems are developed to aid in distinguishing between malignant and benign lesions present in the breast DCE-MR images, the systems need to improve both the sensitivity and specificity of DCE-MR image interpretation in order to be successful for clinical use. A new classifier (a set of features together with a classification method) based on artificial neural networks trained using artificial fish swarm optimization (AFSO) algorithm is proposed in this paper. The basic idea behind the proposed classifier is to use AFSO algorithm for searching the best combination of synaptic weights for the neural network. An optimal set of features based on the statistical textural features is presented. The investigational outcomes of the proposed suspicious lesion classifier algorithm therefore confirm that the resulting classifier performs better than other such classifiers reported in the literature. Therefore this classifier demonstrates that the improvement in both the sensitivity and specificity are possible through automated image analysis.
Diet composition of syntopically breeding falcon species Falco vespertinus and Falco tinnunculus in south-western Slovakia
Authors: Tulis Filip , Slobodník Roman , Langraf Vladimír , Noga Michal , Krumpálová Zuzana , Šustek Zbyšek , Krištín Anton 
Published: December 2017

Abstract
The red-footed falcon and Eurasian falcon represent two syntopical falcon species. While the Eurasian falcon is considered a common and numerous species in Slovakia, the red-footed falcon population has undergone a considerable decline during the past few decades. Nowadays it nests in a single locality in Slovakia, the Sysľovské polia Special Protection Area, which forms the northern and fragmented border of the species distribution area in Europe. By analysing prey remains from 9 nests (from 1998, 2001, 2013, 2014 and 2016), we identified 433 prey items belonging to 35 taxa and 9 orders. Every year, invertebrates made up the major part of the diet spectrum, in which Calosoma auropunctatum, Tettigonia viridissima, Zabrus tenebrioides, Anisoplia aegetum and Rhizotrogus sp. were the most frequent species of prey. Of the vertebrates, Microtus arvalis was the most hunted prey species. By supplementary analysis of 21 photos, we extended our knowledge on the diet by other 6 taxa. The peak of the M. arvalis population growth in 2014 did not manifest itself in the red-footed falcon diet composition. In 1998, 2014 and 2016 we also studied the diet of a syntopical species, the Eurasian kestrel. By analysing prey remains in 22 nests, we identified 1,151 prey items belonging to 37 taxa and 7 orders. In 1998 and 2014 vertebrates predominated, especially the common vole, however in 2016 invertebrates prevailed. This fact could be a reaction to the M. arvalis population peak in 2014 and its decline in 2016. These results suggest that this variability in the foraging behaviour of the Eurasian kestrel, an opportunistic predator, during the hunting of invertebrates increases the diet similarity and overlapping of the food niche of both studied falcon species.
Trend in an isolated population of the red-footed falcon (Falco vespertinus) at the edge of its breeding range (south-western Slovakia)
Authors: Slobodník Roman , Chavko Jozef , Lengyel Jozef , Noga Michal , Maderič Boris , Baláž Michal 
Published: December 2017

Abstract
The population of the red-footed falcon in Slovakia inhabits the north-western edge of the species' breeding range. This breeding population is relatively small and came near to extinction during the population decline of this species in central Europe in recent decades. Thanks to increasing numbers of breeding pairs in Hungary, the Slovak population began to grow again. Moreover, some differences in breeding biology associated with breeding in nest boxes were found. Here we describe the dependence of the small isolated breeding population in Slovakia on the core population in the more eastern parts of the Carpathian Basin, and the impact of supporting activities (nest boxes) on this raptor species in Slovakia.
Open Cardiac Surgery without Blood and Blood Products Transplantation
Authors: Kaplan Mehmet , Can Tolga , Karaagac Anil , Acarel Murat , Olsun Adlan , Yesilkaya M. Inanc , Aydogan Hakki 
Published: December 2017

Background: Blood transfusions are the most common type of tissue and organ transplantation. Perioperative and postoperative transfusions may cause morbidity and mortality and transfusion should based on only hematocrit values but also on hemodynamic and clinical parameters of the patient, which cannot be ignored.Methods: A prospective study was conducted between January 2015 and October 2016 with adult patients undergoing elective open heart surgery. In these patients, a protocol was established, and patients were divided into two groups as transfusion (-) and transfusion (+). In the first 24 hours in the intensive care unit, patients’ drainage, 24-hours urine output, awakening and extubation times, and lactate and bilirubin levels in arterial blood gases were recorded. Thirty-day mortality and morbidity, and hemodynamic and clinical data were compared between these two groups.Results: We have performed a total of 138 cases; no blood and blood products were transfused in 71% (n = 98), and in 29.0% (n = 40) blood and blood products were transfused. Thirty-day mortality and morbidity (arrhythmia, infectious and pulmonary morbidity, myocardial infarction, cerebrovascular accident, renal dysfunction, sternal revision) were compared between these two groups and no statistically significant difference was observed. Patients’ awakening, extubation time, cardiopulmonary bypass period, cross-clamp time, and days in intensive care unit and hospital were compared, and there was no statistically significant difference between the two groups. Conclusion: In this study, we conclude that open heart surgery without blood transfusion may be accomplished with decent peri/postoperative management. The patients who did not receive any blood or blood products were not compromised clinically or hemodynamically. No extra morbidity and mortality were seen in the non-transfusion group. Transfusion decision was based on clinical and hemodynamic parameters such as persistent hypotension or tachycardia, hyperlactatemia, low urine output, and anemic symptoms.