bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of CEA and LDH in relation to KRAS status in patients with unresectable colorectal liver metastases
Authors: Connell Louise C. , Boucher Taryn M. , Chou Joanne F. , Capanu Marinela , Maldonado Stephanie , Kemeny Nancy E. 
Published: December 2016

BACKGROUNDWhile the significance of carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), and Kirsten rat sarcoma (KRAS) status as individual prognostic factors for patients with metastatic colorectal cancer has been addressed, the relationship and interdependence between these prognostic factors on survival is limited.METHODSPatients with unresectable colorectal liver metastases with known KRAS status, and with baseline CEA and LDH levels who were treated with hepatic arterial infusion and systemic chemotherapy were identified. Patients were divided into two groups: hepatic‐only disease and extra‐hepatic disease.RESULTSA total of 193 patients were included: 121 with hepatic‐only and 72 with extra‐hepatic disease. In the hepatic‐only group, median overall survival (OS) was 55 months. On multivariate analysis, KRAS mutated tumors (HR 1.7, P < 0.05), LDH >200 U/L (HR 2.0, P < 0.05), and prior chemotherapy (HR 2.1, P < 0.05) had lower OS. In patients with extra‐hepatic disease, median OS was 32 months. On multivariate analysis, baseline CEA >200 ng/mL (HR 2.1, P = 0.051), LDH >200 U/L (HR 3.8, P < 0.05), and right‐sided tumors (HR 2.8, P < 0.05) had lower OS.CONCLUSIONSThis analysis verifies two distinct patterns in terms of biomarkers in patients with unresectable colorectal liver metastases. In patients with hepatic‐only disease, KRAS mutation and elevated LDH negatively influenced survival. In patients with extra‐hepatic disease, elevated LDH negatively impacted survival.
Arterial ligation versus embolization in epistaxis management: Counterintuitive national trends
Authors: Sylvester Michael J. , Chung Sei Y. , Guinand Luis A. , Govindan Aparna , Baredes Soly , Eloy Jean Anderson 
Published: December 2016

Objectives/HypothesisArterial ligation and embolization are treatment modalities indicated in severe and refractory epistaxis. The purpose of this study was to examine temporal trends and compare outcomes in treatment of hospitalized epistaxis patients with ligation or embolization.MethodsThis retrospective cohort analysis utilized the 2008 to 2013 National Inpatient Sample to identify patients admitted with a primary diagnosis of epistaxis, and an associated procedure code for ligation or embolization.ResultsA total of 1,813 cases met the inclusion criteria, with 57.1% undergoing ligation. During the study period, treatment with ligation has trended downward, whereas treatment with embolization has remained constant. Overall, ligated patients were older (64.1 vs. 62.4 years; P = 0.027) and had higher rates of congestive heart failure (15.1% vs. 9.8%; P = 0.001). No significant differences in rates of chronic pulmonary disease, coagulopathy, liver disease, or hereditary hemorrhagic telangiectasia were observed between cohorts. No differences were observed in rates of blood transfusion, stroke, blindness, or in‐hospital mortality; however, ligated patients had lower rates of intubation/tracheostomy (2.8% vs. 5.3%; P = 0.009). Ligated patients also experienced shorter hospital stays (3.6 vs. 4.0 days; P = 0.014) and incurred lower hospital charges ($33,029 vs. $69,304; P < 0.001).ConclusionCompared to embolization, ligation is associated with significantly decreased hospital charges and shorter hospital stay, without an increase in complication rates. Counterintuitively, ligation appears to be trending downward nationally in its use relative to embolization.Level of Evidence2C Laryngoscope, 127:1017–1020, 2017
Outcomes of surgically treated human papillomavirus–related oropharyngeal squamous cell carcinoma with N3 disease
Authors: Zenga Joseph , Haughey Bruce H. , Jackson Ryan S. , Adkins Douglas R. , Aranake‐Chrisinger John , Bhatt Neel , Gay Hiram A. , Kallogjeri Dorina , Martin Eliot J. , Moore Eric J. , Paniello Randal C. , Rich Jason T. , Thorstad Wade L. , Nussenbaum Brian 
Published: December 2016

Objectives/HypothesisTo evaluate outcomes for patients with pathological N3 (pN3) neck disease from human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) and determine variables predictive of survival.Study DesignRetrospective case series with chart review.MethodsThis study was conducted between 1998 and 2013 and included patients with HPV‐related OPSCC treated with surgery with or without adjuvant therapy and who had pN3 nodal disease. The primary outcome was disease‐specific survival (DSS). Secondary outcomes included overall survival (OS), disease‐free survival (DFS), adverse events, and gastrostomy tube rates.ResultsThirty‐nine patients were included, of whom 36 (90%) underwent adjuvant therapy. Median follow‐up was 39 months (range, 2–147 months). Mean age was 56 years, and 87% were male. Seventeen patients (44%) underwent selective neck dissection, whereas six (15%) underwent radical (n = 2) or extended radical (n = 4) neck dissection. Ninety‐two percent had extracapsular extension. Five‐year Kaplan‐Meier estimated DSS, OS, and DFS were 89% (95% confidence interval [CI]: 79%–99%), 87% (95% CI: 75%–99%), and 84% (95% CI: 72%–96%), respectively. The disease recurrence rate was 10% (5% regional, 5% distant metastasis). Patients with less than 5 pathologically positive lymph nodes (P = .041) had improved DFS.ConclusionsPatients with HPV‐related OPSCC and pN3 nodal disease treated with surgery and adjuvant therapy have very favorable long‐term survival and regional control. Patients with five or more pathologically positive lymph nodes may be at higher risk for recurrence.Level of Evidence4. Laryngoscope, 127:2033–2037, 2017
Conjugated Linoleic Acid/Styrene/Butyl Acrylate Bulk and Emulsion Polymerization for Adhesive Applications
Authors: Roberge Stéphane , Dubé Marc A. 
Published: December 2016

SummaryThe incorporation of conjugated linoleic acid (CLA) into pressure sensitive adhesive (PSA) formulations was evaluated. First, a series of free radical bulk copolymerizations of CLA/styrene (Sty) and CLA/butyl acrylate (BA) were run for reactivity ratio estimation. This was followed by CLA/Sty/BA bulk terpolymerizations. Pseudo‐kinetic models were developed and validated with the copolymerization data and extended and validated for the CLA/Sty/BA terpolymerization case. The pseudo‐kinetic models incorporated the electron trapping effect of oleic acid, a common impurity found in CLA. A series of emulsion terpolymerizations of CLA/Sty/BA were then designed to investigate the influence of terpolymer composition, molecular weight, chain transfer agent concentration, cross‐linker concentration, latex viscosity and particle size on PSA performance (tack, peel strength and shear strength). Empirical PSA performance models were developed and expressed as 3D response surfaces for optimization of the PSA formulation. All experiments were performed at 80°C and monitored with attenuated total reflectance Fourier transform infrared (ATR‐FTIR) spectroscopy both off‐line (bulk experiments) and in‐line (emulsion experiments). Ultimately, the incorporation of 30 wt.% CLA into a practical PSA application suitable for removable adhesives was achieved.
Features of Emulsion Polymerization – How Does the Monomer Move from the Droplets into the Latex Particles?
Authors: Wei Chunxiang , Tauer Klaus 
Published: December 2016

SummaryA series of rather unorthodox swelling experiments with the aid of a recently developed method proves the important influence of monomer droplets for polymer swelling under heterogeneous conditions. This assumption can be used consistently to explain former results of styrene emulsion polymerization in dependence on the stirring rate speed.
A novel design of ultra‐wideband quarter circular microstrip monopole antenna
Authors: Singh R.K. , Pujara Dhaval A. 
Published: December 2016

ABSTRACTThis letter presents a specific design of an ultra‐wideband (UWB) microstrip monopole antenna of dimensions 35 × 25 × 1.6 mm3 realised on FR4 substrate. The UWB performance from 3.1 to 16.3 GHz is achieved with return‐loss better than 10 dB. To achieve UWB performance, a quarter circular patch with tapered microstrip feed line has been used. This antenna has compact and simple structure suitable for fabrication and integration with microwave integrated circuits (MIC). Effect of varying geometric parameters on return‐loss has been studied using Ansoft High Frequency Structure Simulator (HFSS) software. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:225–229, 2017
An X band patch antenna integrated with commercial triple‐junction space solar cells
Authors: Yekan Taha , Baktur Reyhan 
Published: December 2016

ABSTRACTAn X band patch antenna was integrated on top of the cover glass of commercial space‐certified solar cell and was studied for understanding the interaction between the solar cell and the antenna. It was found that the solar cell acts as a lossy substrate for the antenna and reduces the gain of the antenna by about 2 dB, and such a reduction remains consistent for different working states of the solar cell. The patch antenna reduces the efficiency of the solar cells because it blocks light, however, at 10 GHz, the impact of a patch antenna alone to the solar cell's efficiency is less than 1%. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:260–265, 2017
Low‐IF noise characteristics of W‐band resistive and diode mixers
Authors: Lee Seokchul , Lee Sangho , Kwon Youngwoo , Jeong Jinho 
Published: December 2016

ABSTRACTIn this letter, W‐band mixers (resistive and diode mixers) are designed using a 0.15 μm GaAs pseudo‐morphic high electron mobility transistor process for frequency‐modulated continuous wave radars. The measurement shows that both mixers can achieve a good conversion gain of −9 dB with high linearity performance. In addition, noise figures (NFs) of both mixers are measured especially at low intermediate frequency (IF) using a gain method. The resistive mixer exhibits 10.3–11.2 dB lower NF than the diode mixer at low IF from 100 kHz to 1 MHz. This result is also supported by the measurement of the flicker noise of HEMT and diode at each operating bias condition. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:275–278, 2017
A triple band circular polarized monopole antenna for GNSS/UMTS/LTE
Authors: Singh Brar Rajveer , Saurav Kushmanda , Sarkar Debdeep , Vaibhav Srivastava Kumar 
Published: December 2016

ABSTRACTA circularly polarized Y‐shaped monopole antenna with L‐shaped slot loaded ground‐plane is proposed in this letter. The multi‐band operation is achieved due to the resonances of asymmetrical monopole arms as well as the slot in the ground plane. The circular polarization for LTE (band‐7, 2600 MHz) is achieved by using orthogonal and out of phase currents on surface of Y shaped monopole, whereas circular polarization for GNSS and UMTS‐2100 bands is the result of interaction of currents on longer arm of Y shaped monopole and loop currents on ground, which acts as a magnetic monopole. The antenna has been designed and optimised on a low cost FR‐4 epoxy substrate. The proposed antenna exhibits impedance bandwidths of 13.1, 9.7, and 7.4% at the resonant frequencies of 1.57, 2.02, and 2.55 GHz, respectively. At these three resonances, 3 dB axial ratio bandwidths of 3.7, 4.9, and 5.06% are achieved. The antenna has dual sense circular polarization, bidirectional radiation patterns, stable gain and good efficiency in the operating bands. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:298–304, 2017
Low‐cost, compact millimeter‐wave antenna‐in‐package for short‐range wireless communications
Authors: Byeon Chul Woo , Park Chul Soon 
Published: December 2016

ABSTRACTThis article presents a low‐cost, compact millimeter‐wave antenna‐in‐package (AiP) for short‐range wireless communications. The antenna is based on a Yagi‐Uda antenna for high gain and end‐fire radiation and is implemented on a single dielectric layer using a truncated printed circuit board. Integrated with a CMOS transceiver chip, the AiP provides a low‐cost, compact, and robust design. The antenna comprises a microstrip‐to‐coplanar strip line transition, driver, reflector, and director. The fabricated antenna and AiP have dimensions of 6 mm × 5.5 mm × 0.13 mm and 6 mm × 7.2 mm × 0.13 mm, respectively. The antenna has measured beamwidths of 68° (E‐plane) and 105° (H‐plane) and a gain of 6.6 dBi at 60 GHz, while the fabricated AiP achieved a 10.7‐Gb/s wireless data transmission rate over 5 cm at a bit‐error rate of less than 10−12. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:329–333, 2017
A high‐speed Schottky detector for ultra‐wideband communications
Authors: Silva Valdecasa Guillermo , Cimoli Bruno , Blanco Granja Ángel , Bevensee Jensen Jesper , Tafur Monroy Idelfonso , Keinicke Johansen Tom , José Vegas Olmos Juan 
Published: December 2016

ABSTRACTThis letter reviews the design procedure of a high‐speed Schottky video detector for high‐data‐rate communications within the ultra‐wideband (UWB) frequencies. The classic design approach for video detectors is extended with a mixer‐like analysis, which results in a more detailed assessment of the detector performance. The designed circuit is reviewed and measurements are provided for a manufactured prototype. The detector can successfully demodulate 2.5 Gbps video signals around a 7 GHz carrier. The bitrate to carrier frequency ratio of 35.7% is the highest reported for detectors at UWB frequencies. Using 0 dBm carrier power, the lowest measured conversion loss is 10 dB for a video frequency of 1.1 GHz and better than 13 dB up to 1.8 GHz. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:388–393, 2017
A multi‐cavity fiber‐optic device for refractive index measurement
Authors: da Silva Thiago Ferreira , Carneiro Elisa F. 
Published: December 2016

ABSTRACTWe model a multi‐cavity optical device composed of fiber Bragg gratings. The sensitivity of the device for refractive index measurement is extracted from the change in its free‐spectral range, rendering the sensor robust to small temperature fluctuations. Remote interrogation compatibility is ensured by the all‐fiber design. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:423–428, 2017
Coupled‐fed tri‐band MIMO mobile antenna for WWAN and LTE applications
Authors: Zhu Jianfeng , Feng Botao , Deng Li , Peng Biao , Li Shufang 
Published: December 2016

ABSTRACTIn this paper, a coupled‐fed tri‐band multiple‐input‐multiple‐output (MIMO) mobile antenna is proposed for WWAN and LTE applications. The MIMO antenna system is composed of two antenna elements and they are oriented diagonally at the non‐grounded portion of the FR‐4 substrate. Each antenna element consists of a planar inverted‐F antenna (PIFA) coupled‐fed by a L‐shaped driven strip monopole. By adding a parallel‐resonant spiral slit in the main ground, the bandwidth of the lower band can be enhanced to cover the whole GSM850 and GSM900 bands without increasing the antenna size. Slits embedded on the ground are employed to enhance port isolation between the antenna elements. The proposed antenna provides triple bands including the lower band of 810–965 MHz, middle band of 1560–3320 MHz, and upper band of 3400–3590 MHz for WWAN and LTE applications. Detailed geometry and working mechanisms of the antenna are presented. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:463–468, 2017
Cramp‐fasciculation syndrome associated with monofocal motor neuropathy
Authors: Dubuisson Nicolas J. , Van Pesch Vincent , Van Den Bergh Peter Y.K. 
Published: December 2016

ABSTRACTIntroductionCramp‐fasciculation syndrome is a peripheral nerve hyperexcitability disorder, which could be caused by inflammatory neuropathy.Case ReportWe describe a 51‐year‐old woman who presented with a 4‐ to 5‐year history of fasciculations and painful cramping of the right thenar eminence.ResultsElectrophysiological studies showed motor conduction block in the right median nerve between the axilla and the elbow with fasciculation potentials and cramp discharges on electromyography in the right abductor pollicis brevis muscle. High titers of serum anti‐GM1 immunoglobulin M antibodies were detected.ConclusionsMonofocal motor neuropathy of the right median nerve was diagnosed. Intravenous immunoglobulin treatment led to significant improvement of symptoms and signs. Although fasciculations and cramps have been reported in multifocal motor neuropathy and are considered supporting criteria for the diagnosis, the occurrence of cramp‐fasciculation syndrome as the presenting feature and predominant manifestation in monofocal motor neuropathy, a variant of multifocal motor neuropathy, is unique. Muscle Nerve 56: 828–832, 2017
Clinical and biochemical factors associated with preeclampsia in women with obesity
Authors: Vieira Matias C. , Poston Lucilla , Fyfe Elaine , Gillett Alexandra , Kenny Louise C. , Roberts Claire T. , Baker Philip N. , Myers Jenny E. , Walker James J. , McCowan Lesley M. , North Robyn A. , Pasupathy Dharmintra ,   on behalf of the SCOPE Consortium
Published: December 2016

ObjectiveTo compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2) and those with a normal BMI (20–25 kg/m2).MethodsIn 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity.ResultsAmong 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective.ConclusionsWomen with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
Isocyanate‐Free Curing of Glycidyl Azide Polymer with Bis–propargylhydroquinone
Authors: Sonawane Sanjeevani , Anniyappan M. , Athar Javaid , Singh Avtar , Talawar M. B. , Sinha R. K. , Banerjee Shaibal , Sikder A. K. 
Published: December 2016

AbstractBis‐propargylhydroquinone (BPHQ) is an alkyne functionalized isocyanate‐free curing agent for hydroxyl terminated azido polymers. Conventionally, glycidyl azide polymer (GAP) is cured by isocyanate based curatives, which are toxic and hygroscopic in nature. The reaction between hydroxyl end group of GAP and isocyanate is highly sensitive to moisture causing voids in the propellant, leading to poor mechanical properties. Herein, an alternate approach was adapted to exploit 1,3‐dipolar cycloaddition reaction between azido group of GAP and the triple bond (–C≡CH) of BPHQ without catalyst at 50 °C forming triazole crosslinked polymer. The curing behavior of GAP‐BPHQ system was studied by rheological method and based on the results the gel time was determined. In addition, the reaction between GAP and BPHQ was carried out with various GAP/BPHQ ratios (0.9 to 2.5) and effects on mechanical properties of resulting triazole polymers were investigated. Post curing hardness of GAP‐BPHQ binder system was tested by surface Shore‐A hardness measurement. The compatibility of BPHQ with energetic oxidizers such as ammonium dinitramide (ADN) and hydrazinium nitroformate (HNF) were also studied by differential scanning calorimetery (DSC) technique and showed good compatibility. The activation energy (Ea) of cured GAP‐BPHQ binder was evaluated by DSC using Ozawa and Kissinger methods and are found to be 33.55 and 33.16 kcal mol–1, respectively. The advantage of this curing system between GAP and BPHQ is unaffected by moisture as compared to isocyanate based urethane systems and also no need to control humidity during the processing of propellant. The experimental results reveal that triazole crosslinked polymer system could be a better choice to develop novel energetic binder systems for explosives as well as propellants composition with improved performance and eco‐friendly nature.
Thermochemistry of Evaporation and Sublimation of 2,4,6‐Triazido‐1,3,5‐triazine
Authors: Korsunskiy Boris L. , Nedel'ko Vadim V. , Zakharov Viktor V. , Chukanov Nikita V. , Chervonnyi Alexandr D. , Larikova Tatiana S. , Chapyshev Sergey V. 
Published: December 2016

AbstractSaturated vapor pressure over cyanuric triazide melt was measured in the temperature range 393.15–453.15 K using glass membrane Bourdon pressure gauges. Measured evaporation heat and evaporation entropy are equal to 61.1±3.3 kJ mol–1 and 111.3±6.1 J mol–1 K–1, respectively. According to DSC data, melting heat and melting entropy of cyanuric triazide are 22.2±1.3 kJ mol–1 and 60.5±3.5 J mol–1 K–1, respectively. Based on the results obtained, the following dependence was found for the saturated vapor pressure over solid cyanuric triazide: Ps [Pa]=1014.0⋅exp[(–83300±3300)/RT]. Concequently, sublimation heat and sublimation entropy of cyanuric triazide are equal to 83.3±3.3 kJ mol–1 and 171.8±9.6 J mol–1 K–1, respectively. Saturated vapor pressure over solid cyanuric triazide at room temperature is equal to 0.25 Pa (1.9×10−3 Torr). It is concluded that high volatility of cyanuric triazide is caused by its low sublimation heat.
Maternal immune correlates of protection from human cytomegalovirus transmission to the fetus after primary infection in pregnancy
Authors: Lilleri Daniele , Gerna Giuseppe 
Published: December 2016

SummaryImmune control of primary human cytomegalovirus (HCMV) infection appears to depend on the interaction of humoral and T‐cell responses. In this review, we have separately explored the 2 arms of the immune response to primary HCMV infection in HCMV‐seronegative pregnant women transmitting (T) or not transmitting (NT) the infection to the fetus, with the objective of correlating the immune risk factors associated with vertical HCMV transmission. As for the humoral response, the following findings were documented: (i) in competitive binding assays, antibody titers to different antigenic sites of the gH pentamer complex were significantly lower in T compared with NT women; (ii) in addition, the number of neutralization sites recognized by T was significantly lower compared with NT women; (iii) the plaque formation inhibition assay showed a faster kinetics and a higher titer in NT women. As for T‐cell immunity, the delayed expression of 3 immunological parameters (lymphoproliferative response, CD45RA reexpression in both CD4+ and CD8+ HCMV‐specific T cells, and interleukin‐2 production by HCMV‐specific CD4+ T cells) were significantly associated with vertical transmission. This overview provides important information at the population level, which may help to inform the evaluation of interventions such as vaccination or treatments designed to interrupt intrauterine transmission of HCMV during primary infection. However, although we are waiting for an HCMV vaccination to become available, we emphasize that none of these parameters can be prognostically used on an individual basis because of the great variation in values among women.