bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extreme enthalpy‒entropy compensation in the dimerization of small solutes in aqueous solution
Authors: Scott David J. , Winzor Donald J. 
Published: October 2024

AbstractThis communication summarizes findings from the earliest encounters with extreme enthalpy‒entropy compensation, a phenomenon first detected in the 1950s by a reappraisal of isopiestic and calorimetric measurements on aqueous urea solutions in terms of solute self-association. Because concurrent studies of carboxylic acid association were confined to measurement of the equilibrium constant by conductance, IR spectrophotometry or potentiometric titration measurements, temperature-independence of the dimerization constant was mistakenly taken to signify a value of zero for Δ$$H^o$$

H
o

instead of (Δ$$H^o$$

H
o

‒ TΔ$$S^o$$

S
o

). In those studies of small-solute self-association the extreme enthalpy‒entropy compensation was reflecting the action of water as a reactant whose hydroxyl groups were competing for the solute carbonyl involved in self-association. Such action gives rise to a positive temperature dependence of Δ$$H^o$$

H
o

that could well be operating in concert with that responsible for the commonly observed negative dependence for protein‒ligand interactions exhibiting extreme enthalpy‒entropy compensation, where the solvent contribution to the energetics reflects changes in the extent of ordered water structure in hydrophobic environments.
Quantitative Assessment of New Frontiers in Dermatochalasis and Periorbital Hyperpigmentation Treatment: The Role of Cross-Linked Porcine Collagen
Authors: Chuang Andy Deng-Chi , Lin Erh-Ti , Wu Bing-Qi , Lu Meng-En , Chiang Hsiu-Mei , Chu Pai-Nien , Lin Bor-Shyh , Chang Chang-Cheng 
Published: October 2024

Abstract
Background
Collagen dermal fillers have shown efficacy in addressing age-related changes in facial appearance. However, their potential in rejuvenating the periorbital region remains unexplored. The aim of this study was to evaluate the effectiveness, clinical safety, and patient satisfaction associated with the utilization of collagen dermal fillers in individuals with dermatochalasis and periorbital hyperpigmentation.

Methods
This study was reviewed and approved by the institutional review board of China Medical University Hospital (IRB No. CMUH107-REC2-157). Adults diagnosed with dermatochalasis or periorbital hyperpigmentation received periorbital injections of a sterile cross-linked highly-purified specific antigen free porcine dermal collagen (FACIALGAIN® Collagen Implant with Lidocaine, Sunmax Biotechnology Co. Ltd., Taipei, Taiwan) and were assessed for hydration, elasticity, pigmentation index, redness index, lightness value, and density with the DermaLab® Combo Multiparameter Skin Analysis System (Cortex Technology, Hadsund, Denmark) and Cutometer® Dual MPA 580 (Courage+Khazaka electronic GmbH, Köln, Germany). Data was collected prior to injection and at 1 week, 4 weeks, and 12 weeks after injection. Patient satisfaction on volume augmentation, decrease in hyperpigmentation, persistence, and overall satisfaction were also recorded.

Results
A total of 12 samples each were recruited for dermatochalasis and periorbital hyperpigmentation. For dermatochalasis subjects, hydration of the periorbital tissue significantly increased at week 1 and 4 (p = 0.011 and p = 0.015). Elasticity decreased by week 4 and persisted until week 12 (p = 0.001 and 0.014). For periorbital hyperpigmentation patients, lightness value increased significantly starting week 1 (p = 0.016), tapering off at week 12. Elasticity decreased by week 4 and persisted until week 12 (p = 0.002 and p = 0.002). Median overall patient satisfaction was 4 out of 5 for the dermatochalasis group and 4.5 out of 5 for the periorbital hyperpigmentation group, with a mild but insignificant decrease by week 12.

Conclusions
DermaLab® Combo and Cutometer® Dual MPA 580 are considered effective methods for evaluating patients undergoing dermal filler injections. The utilization of cross-linked porcine collagen dermal filler injections can serve as a minimally invasive approach to enhance skin laxity in dermatochalasis and address discoloration in periorbital hyperpigmentation. However, it is important to note that regular treatments may be necessary to sustain the desired outcomes.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/0026.
Percutaneous Cryoablation in the Liver: A Meta-Analysis and Review of Safety with a Focus on Incidence of Cryoshock and Major Complications
Authors: Kolck Johannes , Schulze Daniel , Brönnimann Michael , Fürstner Matthias , Fehrenbach Uli , Collettini Federico , Gebauer Bernhard , Auer Timo A. 
Published: October 2024

Abstract
Purpose
The aim of the present meta-analysis was to systematically determine the overall complication rate and incidence of cryoshock in patients undergoing cryoablation of the liver.

Methods
A systematic review and meta-analysis adhering to the PRISMA guidelines and focusing on studies of cryotherapy for liver malignancies published after 2000 were conducted. PubMed, Web of Science, Embase, and Scopus were systematically searched for articles reporting incidences of adverse events associated with percutaneous cryoablation in patients with liver malignancies. Data extraction and screening were independently conducted by two reviewers, who resolved discrepancies through consensus. Statistical analysis was performed to assess heterogeneity and pooled complication rates and included a moderator analysis to explore factors influencing the occurrence of complications.

Results
The initial search yielded 4,145 articles, of which 26 met our inclusion criteria. From these 26 articles, pooled data on 4,029 patients were extracted. Variance between studies reporting cryoshock was low (I2 = 13.15%), while variance among studies reporting major complications was high (I2 = 82.52%). The pooled weighted proportion of major complications was 4.71% while that of cryoshock was as low as 0.265%. Moderator analysis identified publication year as the only moderator for major complications and no moderator for the occurrence of cryoshock.

Conclusion
Analysis of currently available evidence indicates that cryoablation has a relative safe profile with a pooled incidence of major complications below 5%. Cryoshock occurred in less than 0.3% of procedures and was not reported for liver lesions smaller than 3 cm.
Enhanced transanal surgery training through a 4K 3D surgical exoscope: a novel approach for transanal surgery
Authors: Spinelli Antonino , Chardalias Leonidas , Carvello Michele , Sacchi Matteo , Siragusa Leandro , La Raja Carlotta 
Published: October 2024

Abstract
Purpose
Recently, exoscope was introduced as a more ergonomic alternative to microscope, mainly in nerve and spinal surgery. Exoscope use in general surgery is still experimental and just few reports are present in literature. Here, we describe for the first time its application in transanal surgery, specifically during the transanal transection and single-stapled anastomosis in ileal-pouch anal anastomosis.

Methods
After completing the proctectomy and pouch formation laparoscopically, two surgeons performed the transanal transection and single-stapled anastomosis using the vision provided by the ORBEYE™ exoscope system with a 3D 4K orbital camera and a 55-inches 3D screen. The transanal procedure was carried out with the surgeons looking at the 3D screen rather than at the operating field.

Results
The system subjectively provided excellent operative view thanks to the magnification capacity and the high resolution. The ergonomics was improved compared to classical transanal surgery, allowing the operators and observers to have the same view in a comfortable position. In particular, the exoscope magnified vision allowed for clearer demonstration of techniques to trainees.

Conclusions
This is the first report on the intraoperative application of the ORBEYE™ surgical exoscope in transanal surgery. The magnified vision allowed precise movements and the system appeared potentially a ground-breaking tool for surgical training. The ability to project high-quality images to observers make it ideal for teaching complex transanal procedures. Further studies are encouraged to validate this approach into standard colorectal practice.
Innovations in ultrasound training in obstetrics
Authors: Wittek Agnes , Strizek Brigitte , Recker Florian 
Published: October 2024

AbstractIntroductionUltrasound technology is critical in obstetrics, enabling detailed examination of the fetus and maternal anatomy. However, increasing complexity demands specialised training to maximise its potential. This study explores innovative approaches to ultrasound training in obstetrics, focussing on enhancing diagnostic skills and patient safety.MethodsThis review examines recent innovations in ultrasound training, including competency-based medical education (CBME), simulation technologies, technology-based resources, artificial intelligence (AI), and online-learning platforms. Traditional training methods such as theoretical learning, practical experience, and peer learning are also discussed to provide a comprehensive view of current practises.ResultsInnovations in ultrasound training include the use of high-fidelity simulators, virtual reality (VR), augmented reality (AR), and hybrid-learning platforms. Simulation technologies offer reproducibility, risk-free learning, diverse scenarios, and immediate feedback. AI and machine learning facilitate personalised-learning paths, real-time feedback, and automated-image analysis. Online-learning platforms and e-learning methods provide flexible, accessible, and cost-effective education. Gamification enhances learning motivation and engagement through educational games and virtual competitions.DiscussionThe integration of innovative technologies in ultrasound training significantly improves diagnostic skills, learner confidence, and patient safety. However, challenges such as high costs, the need for comprehensive instructor training, and integration into existing programs must be addressed. Standardisation and certification ensure high-quality and consistent training. Future developments in AI, VR, and 3D printing promise further advancements in ultrasound education.ConclusionInnovations in ultrasound training in obstetrics offer significant improvements in medical education and patient care. The successful implementation and continuous development of these technologies are crucial to meet the growing demands of modern obstetrics.
Conventional one-handed compared to two-handed endoscopic ear surgery using an endoscope holder: a single center study
Authors: Müller Christoph , Raczynski Anastasia , Lailach Susen , Zahnert Thomas 
Published: October 2024

Abstract
Introduction
One-handedness is a challenge in conventional endoscopic ear surgery (EES). We present results on the first-ever application of the passive endoscope holder ‘Endofix exo’ (Co. AKTORmed GmbH, Neutraubling, Germany) in EES, which enables two-handed surgery.

Methods
This two-sided study compares cut-suture time, operating time, postoperative complications, graft take rates, hearing results and quality of life in patients who underwent first stage tympanoplasty due to tympanic membrane perforation with intact ossicular chain conditions. 25 patients received classic EES (EES-, mean age: 28 ± 21 years) and 15 received EES with the passive holder (EES+, mean age: 48 ± 21 years).

Results
Mean operating times (EES-: 96 ± 38 (SD) min; EES+: 107 ± 33 min), cut-suture times (EES-: 68 ± 30 min; EES+: 73 ± 31 min), complications, graft take rates and hearing results (preoperative air bone gap (ABG) (PTA4): 15 dB ± SD 8 dB (EES-); 16 dB ± SD 8 dB (EES+); postoperative ABG (PTA4): 11.25dB ± SD 11.3dB (EES-); 14 dB ± SD 10 dB (EES+)) did not differ significantly (p > 0.05) between the two groups. Postoperative hearing results and quality of life tended to improve in both groups (p > 0.05).

Discussion
The passive endoscope holder has been successfully applied during the course of the study. However, modifications of the endoscope holder and further studies are recommended focusing on positioning of grafts and prostheses to obtain conclusive results regarding the superiority of two-handed EES over one-handed conventional EES.
Changes in weight secondary to improved odor perception in chronic rhinosinusitis with nasal polyps’ patients treated with Dupilumab
Authors: Rosso Cecilia , De Corso Eugenio , Urbanelli Anastasia , Fadda Gianluca , Saibene Alberto Maria , Ferella Francesco , Spanu Camilla , Pipolo Carlotta 
Published: October 2024

Abstract

Purpose
The advent of biologic therapies, notably Dupilumab, has transformed therapeutic approaches to nasal polyposis. This retrospective multicentric study aimed to investigate weight changes in CRSwNP patients undergoing Dupilumab treatment and explore potential correlations with olfactory improvement.

Methods
Ninety-six patients with CRSwNP were followed for at least 12 months, with assessments including BMI (Body Mass Index), olfactory function, and disease severity.

Results
Significant increases in BMI and olfactory perception were observed after 1 year of Dupilumab treatment (p < .001). Subgroup analysis showed that patients with hyposmia and normosmia at T12 (1-year follow up) experienced significant weight gain (p < .001) alongside improved olfaction (both p < .001). Conversely, patients with anosmia after 1 year of therapy and also patients with stable or worsened olfaction did not show significant BMI changes (respectively p = .201 and p = .107).

Conclusion
While these findings suggest a correlation between olfactory improvement and weight gain/BMI, factors like improved nasal airflow and corticosteroid cessation under Dupilumab treatment may also influence weight in CRPwNP patients. The study highlights the need for further research to elucidate the causal relationship and long-term implications of Dupilumab-induced olfactory improvement on weight regulation.
Effect of Fresnel prism in small-angle esotropia (≤ 20 prism diopters) with fixation preference
Authors: Joo Hye Jun , Kim Seong-Joon 
Published: October 2024

Abstract
Purpose
We aimed to investigate the effects of Fresnel prism treatment for small-angle esotropia (≤ 20 prism diopters [PD]) with fixation preference.

Methods
We included 32 patients with remaining esotropia ≤ 20 PD measured using the simultaneous prism and cover test (SPCT) after full refractive error correction. Fresnel prism was applied to make patients orthotropic with glasses. Treatment was discontinued if remaining esotropia ≤ 4 PD was sustained during two consecutive follow-ups (2-month intervals) or if the angle continued to increase with prism adaptation. Patients were divided into treatment success and failure groups. Treatment success was defined by motor and visual acuity (VA) aspects. Criteria for motor success was residual esotropia ≤ 8 PD in patients with initial esotropia > 8 PD and a 30% decrease of esotropia in those with initial esotropia ≤ 8 PD. VA success was improvement of > 0.2 logMAR in the non-dominant eye.

Results
The initial esodeviation angle was 6.92 ± 4.66 PD at distance and 10.53 ± 5.58 at near. The logMAR VA was 0.10 ± 0.13 and 0.26 ± 0.20 in the dominant and non-dominant eye, respectively. Among the 32 patients, 14 showed motor success. Among 26 patients whose VA could be measured, 15 showed VA success. Factors influencing motor success were a small amount of maximum prescribed Fresnel prism, less frequent need for Fresnel prism adaptation, and high percentage of achieving orthotropia with Fresnel prism treatment. VA success was influenced by low frequency of anisometropia and the small amount of maximum prescribed Fresnel prism.

Conclusion
Fresnel prism could be a non-invasive treatment option for some patients with small-angle esotropia with fixation preference.

Key messages
What is known

The optimal approach for addressing small-angle esotropia is a topic of debate.

Not much research has been conducted on Fresnel prism treatment in patients with small-angle esotropia.

What is new

Motor success and visual acuity improvement were observed in some patients undergoing Fresnel prism treatment.

Factors contributing to motor success were the small maximum angle of esodeviation, the less frequent necessity for Fresnel prism adaptation, and the achievement of orthotropia during Fresnel prism treatment.

Visual acuity improvement was hindered by the presence of anisometropia and the large maximum prescribed amount of Fresnel prism.

Fresnel prism treatment can be used as a treatment option for some patients with small-angle esotropia with fixation preference.
Mortality of alzheimer’s disease in Italy from 1980 to 2015
Authors: Bezzini Daiana , Smeralda Carmelo L. , Pasqualetti Patrizio , Cappa Stefano F. , Kundisova Lucia , Rossi Simone , Ulivelli Monica 
Published: October 2024

Abstract
Objective
To evaluate mortality for Alzheimer’s Disease (AD) in Italy over more than three decades (1980–2015) and discuss the possible role of general and specific contributing factors.

Methods
Mortality data were extracted by the Italian National Institute of Statistics: crude mortality rates were computed for sex and age, considering the whole country and its five main geographical sub-areas. Rates were standardized in two ways: directly (annual mortality rates AMRs) and indirectly (standardized mortality rates, SMRs). SMRs were then used to evaluate geographical differences; to study mortality trend, AMRs and joinpoint linear regression analysis were used.

Results
Considering the entire period and the whole country, mortality rates were similar for females and males and for geographical regions, with the exception of the older age groups where mortality for AD in females slightly prevailed. In these older patients, a steep increase of mortality was seen starting from the current century. The increase in male mortality mirrored the national trend in North-West and Central Italy, but not in North-East, South, and the Islands, where it did not surge until the mid to late 1990s.

Conclusions
the general increase of mortality is in line with international data and it reflects the increasing prevalence of the disease, likely due to increasing longevity, and to improvements in diagnostic accuracy. In addition, the accuracy of death certificate compilation could account for both geographical and temporal differences. Currently available drugs for AD do not seem to have an impact on mortality rates.
Bacterial isolates from drinking water river sources exhibit multi-drug resistant trait
Authors: Popoola Bukola Margaret , Ogwerel Jemimah Pearl , Oladipo Oluwatosin Gbemisola 
Published: October 2024

AbstractFreshwater habitat is a natural reservoir for antimicrobial resistance (AMR). AMR poses serious human, animal, and environmental public health threats. This study aimed to evaluate the physicochemical and microbiological quality of five selected rivers (Apitipiti 1, Apitipiti 2, Apitipiti 3, Sogidi, and Aba Apa Akinmorin) in Oyo town, Nigeria, as well as the antibiotic resistance pattern of isolated bacterial species, using conventional methods. Most physicochemical parameters were within WHO and NIS permissible limits. Pearson’s correlation matrix indicated that there were significant (p < 0.05) interactions among pH, electrical conductivity, temperature, sulphate and chloride salts, and BOD and COD. A total of thirty-two (32) bacterial species were isolated and identified as: Aeromonas (9), Bacillus (2), Corynebacterium (13), Lactobacillus (1), Pseudomonas (2), Staphylococcus (4), and Streptococcus (1). Of the rivers, Sogidi had the highest microbial load (6.36 log CFU/mL) while Apititipiti 1 had the lowest (5.76 log CFU/mL). With regard to antibiotic sensitivity, 81.8% were multidrug-resistant, with Corynebacterium kutscheri and Aeromonas spp. isolated from Apitipiti 2 and Aba Apa Akinmorin rivers, respectively, exhibiting a relatively high antibiotic resistance of 90.9%. This study reveals that these rivers may be unfit for consumption as multidrug-resistant bacteria of public health risk were associated with them.
Bringing Traditional Medicine into the Health Humanities Classroom with Kali Fajardo-Anstine’s “Remedies”
Authors: Libow Jess , Grubbs Lindsey 
Published: October 2024

AbstractIn this essay, we recommend Kali Fajardo-Anstine’s short story “Remedies” (2019) for inclusion on health humanities syllabi based on our experiences teaching it at two undergraduate institutions. The story is drawn from Sabrina & Corina, Fajardo-Anstine’s award-winning book of short stories about Chicana and Indigenous women in Colorado, but is available for free online, making it highly accessible for students. “Remedies” is narrated by Clarisa, who turns to her great-grandmother Estrella for the traditional knowledge that ultimately cures her family’s recurrent outbreaks of lice. As a health narrative that centers familial and cultural healing practices, “Remedies” offers a much needed counterpart to the biomedical frameworks that tend to dominate health humanities syllabi and curricula. At the same time that it illuminates the physical and emotional efficacy of such practices, “Remedies” rejects a binary that pits them against biomedicine, offering a complex portrait of how various members of a family integrate traditional and biomedical approaches to health. We discuss how themes related to familial and cultural healing practices are developed in the story and introduce our approach to initiating productive conversations about the relationship between traditional healing and biomedicine in our classrooms.
Landslide displacement prediction using time series InSAR with combined LSTM and TCN: application to the Xiao Andong landslide, Yunnan Province, China
Authors: Li Jia , Fan Chengpeng , Zhao Kang , Zhang Zhike , Duan Ping 
Published: October 2024

AbstractResearch on landslide displacement prediction based on interferometric synthetic aperture radar (InSAR) deformation data involves two main issues. First, InSAR can provide only one-dimensional deformation data along the satellite’s line of sight (LOS), which cannot truly reflect the deformation of the landslide body in the downward direction along the slope. Second, the use of a single prediction model does not adequately account for both long-term and local changes in landslide displacement, affecting the accuracy of the predictions. To address this, in this study, Long Short-Term Memory networks (LSTM) and temporal convolutional network (TCN) models are combined to construct a method (LSTM-TCN) of landslide displacement prediction. This method can consider the long-term and localized changes in landslide displacement. The method is first based on InSAR technology to obtain surface deformation. The deformation of the landslide is subsequently computed in the downward direction along the slope to obtain the landslide displacement time series data. Next, the LSTM-TCN is used for landslide displacement prediction. Finally, the mean absolute error (MAE), root mean square error (RMSE) and coefficient of determination (R2) are used to evaluate the performance of the model. The experiment is conducted on the Xiao Andong landslide in Anshi village, Fengqing County, Lincang City, Yunnan Province, China. The LSTM-TCN model achieves an R2 of 0.75, an RMSE of 0.43 cm, and an MAE of 0.36 cm. Compared with the individual LSTM and TCN models, the LSTM-TCN model exhibits the highest prediction accuracy and the smallest prediction error, which is closer to the true result that in the other models. These results demonstrate that the combined LSTM-TCN model effectively captures the complex features and long-term trends in landslide displacement data, significantly enhancing the accuracy of predictions.