bluuebunny/crossref_metadata_2025_split huggingface dataset:
Definition and diagnosis of Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology
Authors: Hopfner Franziska , Höglinger Günter ,   German Parkinson’s Guidelines Group, Bähr Mathias , Becktepe Jos , Berg Daniela , Brockmann Kathrin , Ceballos-Baumann Andrés , Claßen Joseph , Deuschl Cornelius , Deuschl Günther , Dodel Richard , Ebersbach Georg , Eggers Carsten , van Eimeren Thilo , Fanciulli Alessandra , Fimm Bruno , Folkerts Ann-Kristin , Gausepohl Madeleine , Hasan Alkomiet , Hermann Wiebke , Hilker-Roggendorf Rüdiger , Höllerhage Matthias , Jost Wolfgang , Kalbe Elke , Kassubek Jan , Klebe Stephan , Klein Christine , Klietz Martin , Köglsperger Thomas , Kühn Andrea , Krack Paul , Krismer Florian , Kuhlenbäumer Gregor , Levin Johannes , Liepelt-Scarfone Inga , Lingor Paul , Loewenbrück Kai , Löhle Matthias , Maaß Sylvia , Maetzler Walter , Menzel Regina , Meyer Philipp T , Mollenhauer Brit , Neumann Manuela , Odin Per , Outeiro Tiago , Pötter-Nerger Monika , Reese René , Reetz Kathrin , Rieß Olaf , Ruf Viktoria , Schneider Anja , Schrader Christoph , Schnitzler Alfons , Seppi Klaus , Sixel-Döring Friederike , Storch Alexander , Tönges Lars , Walter Uwe , Wächter Tobias , Warnecke Tobias , Wegner Florian , Winkler Christian , Witt Karsten , Woitalla Dirk , Zeuner Kirsten , Trenkwalder Claudia 
Published: September 2024

Abstract
Background
Accurate definition and operational criteria for diagnosing Parkinson’s disease (PD) are crucial for evidence-based, patient-centered care.

Objective
To offer evidence-based recommendations for defining and diagnosing PD, incorporating contemporary clinical, imaging, biomarker, and genetic insights.

Methods
The guideline development began with the steering committee establishing key PICO (patient, intervention, comparison, outcome) questions, which were refined by the coauthors. Systematic literature searches identified relevant studies, reviews, and meta-analyses. Recommendations were drafted, evaluated, optimized, and voted upon by the German Parkinson’s Guideline Group.

Results
Parkinson’s disease (PD) is now understood to encompass a broader spectrum of etiologies than previously recognized. Advances in molecular pathogenesis, neuroimaging, and early clinical phenotypes suggest that PD is not a uniform disease entity and is often not idiopathic. This necessitates an updated framework for PD definition and diagnosis. The German Society for Neurology now endorses a broader concept of PD, incorporating both idiopathic and hereditary forms, as opposed to the previously narrower concept of “idiopathic Parkinson syndrome.” The revised guidelines recommend using the 2015 Movement Disorders Society diagnostic criteria, emphasize the importance of long-term clinical follow-up for improved diagnostic accuracy, and highlight the significance of non-motor symptoms in clinical diagnosis. Specific recommendations are provided for the use of imaging and fluid biomarkers and genetic testing to support the clinical diagnosis.

Conclusion
The updated guidelines from the German Society for Neurology enhance diagnostic accuracy for PD, promoting optimized clinical care.
Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length
Authors: Glueck Melanie , Lucaciu Alexandra , Subburayalu Julien , Kestner Roxane Isabelle , Pfeilschifter Waltraud , Vutukuri Rajkumar , Pfeilschifter Josef 
Published: September 2024

AbstractSphingosine-1-phosphate (S1P) is a bioactive lipid signaling molecule with pleiotropic implications by both auto- and paracrine signaling. Signaling occurs by engaging five G protein-coupled receptors (S1P1-5) or intracellular pathways. While the extensively studied S1P with a chain length of 18 carbon atoms (d18:1 S1P) affects lymphocyte trafficking, immune cell survival and inflammatory responses, the biological implication of atypical S1Ps such as d16:1 or d20:1 remains elusive. As S1P lipids have far-reaching implications in health and disease states in mammalian organisms, the previous contrasting results may be attributed to differences in S1P’s alkyl chain length. Current research is beginning to appreciate these less abundant atypical S1P moieties. This review provides an up-to-date foundation of recent findings on the biological implications of atypical S1P chain lengths and offers a perspective on future research endeavors on S1P alkyl chain length–influenced signaling and its implications for drug discovery.
Why do we study sphingolipids?
Authors: Futerman Anthony H. 
Published: September 2024

AbstractResearch on sphingolipids has proliferated exponentially over the past couple of decades, as exemplified in the findings reported at the International Leopoldina Symposium on Lipid Signaling held in Frankfurt in late 2023. Most researchers in the field study how sphingolipids function in regulating a variety of cellular processes and, in particular, how they are dysregulated in numerous human diseases; however, I now propose that we implement a more holistic research program in our study of sphingolipids, which embraces a sense of awe and wonder at the complexities and beauty of sphingolipids and of sphingolipid metabolism. I will outline the chemical complexity of sphingolipids, their modes of interaction within the lipid bilayer, and their biosynthetic pathways. I will then briefly touch upon the ability of current neo-Darwinian mechanisms to explain the emergence of both sphingolipids and of the complex pathways that generate them. Although such discussion is normally considered taboo in biological circles, I nevertheless submit that in-depth analysis of the minutiae of metabolic pathways, such as those of the sphingolipid biosynthetic pathway, raises challenges to current neo-Darwinian mechanisms that should not be shunned or ignored.
Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals
Authors: Quiñones Ileana , Gisbert-Muñoz Sandra , Amoruso Lucía , Manso-Ortega Lucia , Mori Usue , Bermudez Garazi , Robles Santiago Gil , Pomposo Iñigo , Carreiras Manuel 
Published: September 2024

AbstractResearch on the neural imprint of dual-language experience, crucial for understanding how the brain processes dominant and non-dominant languages, remains inconclusive. Conflicting evidence suggests either similarity or distinction in neural processing, with implications for bilingual patients with brain tumors. Preserving dual-language functions after surgery requires considering pre-diagnosis neuroplastic changes. Here, we combine univariate and multivariate fMRI methodologies to test a group of healthy Spanish-Basque bilinguals and a group of bilingual patients with gliomas affecting the language-dominant hemisphere while they overtly produced sentences in either their dominant or non-dominant language. Findings from healthy participants revealed the presence of a shared neural system for both languages, while also identifying regions with distinct language-dependent activation and lateralization patterns. Specifically, while the dominant language engaged a more left-lateralized network, speech production in the non-dominant language relied on the recruitment of a bilateral basal ganglia-thalamo-cortical circuit. Notably, based on language lateralization patterns, we were able to robustly decode (AUC: 0.80 ± 0.18) the language being used. Conversely, bilingual patients exhibited bilateral activation patterns for both languages. For the dominant language, regions such as the cerebellum, thalamus, and caudate acted in concert with the sparsely activated language-specific nodes. In the case of the non-dominant language, the recruitment of the default mode network was notably prominent. These results demonstrate the compensatory engagement of non-language-specific networks in the preservation of bilingual speech production, even in the face of pathological conditions. Overall, our findings underscore the pervasive impact of dual-language experience on brain functional (re)organization, both in health and disease.
Redescription of Dracovermis occidentalis (Digenea: Liolopidae) infecting American alligator, Alligator mississippiensis from the Bon-Secour River (Mobile–Tensaw River Delta, Alabama, USA) and a revised phylogeny for Liolopidae
Authors: Dutton Haley R. , Bullard Stephen A. , Brule John H. , Kelly Anita M. 
Published: September 2024

AbstractWe examined several American alligators, Alligator mississippiensis (Daudin, 1802) (Crocodilia: Alligatoridae) from Louisiana, Alabama, and South Carolina in August 2022. The intestine of one alligator from Alabama was infected by Dracovermis occidentalis Brooks and Overstreet, 1978 (Platyhelminthes: Digenea: Liolopidae Odhner, 1912), a seldom collected and incompletely described trematode that lacks a representative nucleotide sequence. Liolopidae comprises 5 genera and 15 species: Liolope spp. infect giant salamanders; Helicotrema spp. infect turtles and lizards; Harmotrema spp. infect snakes; Paraharmotrema spp. infect turtles; and Dracovermis spp. infect crocodilians. Based on our study of the newly collected specimens and the holotype of D. occidentalis, we redescribe D. occidentalis, correct errors in its original description, and provide an updated phylogeny for Liolopidae that, for the first time, includes Dracovermis Brooks and Overstreet, 1978. Our specimens were identified as D. occidentalis by having testes in the posterior 1/3 of the body, a pretesticular cirrus sac, a spined and eversible cirrus, a bipartite seminal vesicle, and a post-acetabular vitellarium. A phylogenetic analysis of the D1–D3 domains of the nuclear large subunit ribosomal DNA (28S) recovered Liolopidae as monophyletic; however, low taxon sampling in the group precludes hypothesis-testing about liolopid-vertebrate cophyly. This is the first collection for morphological study of the type species for Dracovermis since the genus was proposed 46 years ago, the first record of a liolopid from Alabama, and the first phylogenetic analysis that includes Dracovermis.
Die Geschichte der Mathematischen Gesellschaft der DDR (Teil II): von der Gründung bis zur Wende
Authors: Sperber Wolfram 
Published: September 2024

ZusammenfassungDer Artikel beschreibt die Tätigkeit und die Rahmenbedingungen der Mathematischen Gesellschaft der DDR, MGDDR, von der Gründung bis zur Wende. Er setzt die Darstellung der Vorgeschichte der MGDDR fort, die aus den Entwicklungen Deutschlands nach dem II. Weltkrieg resultiert, siehe auch Teil 1 [1]. Einerseits entwickelte die MGDDR in der DDR ein eigenständiges mathematisches Leben und förderte vielfältige Aktivitäten in der mathematischen Schulbildung und Weiterbildung, andererseits war die MGDDR in die Politik von Partei und Staat in der DDR eingebunden, was sich etwa in der Überwachung und Verhinderung von Kontakten zu mathematischen Fachgesellschaften und Mathematikern aus nicht-sozialistischen Ländern zeigt.
Why are inner planets not inclined?
Authors: Clarke Andrew , Fejoz Jacques , Guardia Marcel 
Published: September 2024

AbstractPoincaré’s work more than one century ago, or Laskar’s numerical simulations from the 1990’s on, have irrevocably impaired the long-held belief that the Solar System should be stable. But mathematical mechanisms explaining this instability have remained mysterious. In 1968, Arnold conjectured the existence of “Arnold diffusion” in celestial mechanics. We prove Arnold’s conjecture in the planetary spatial 4-body problem as well as in the corresponding hierarchical problem (where the bodies are increasingly separated), and show that this diffusion leads, on a long time interval, to some large-scale instability. Along the diffusive orbits, the mutual inclination of the two inner planets is close to $\pi /2$
π
/
2
, which hints at why even marginal stability in planetary systems may exist only when inner planets are not inclined. More precisely, consider the normalised angular momentum of the second planet, obtained by rescaling the angular momentum by the square root of its semimajor axis and by an adequate mass factor (its direction and norm give the plane of revolution and the eccentricity of the second planet). It is a vector of the unit 3-ball. We show that any finite sequence in this ball may be realised, up to an arbitrary precision, as a sequence of values of the normalised angular momentum in the 4-body problem. For example, the second planet may flip from prograde nearly horizontal revolutions to retrograde ones. As a consequence of the proof, the non-recurrent set of any finite-order secular normal form accumulates on circular motions – a weak form of a celebrated conjecture of Herman.
A second Artemisia pollen peak in autumn in Vienna: reaching the point of no return?
Authors: Bastl Katharina , Bastl Maximilian , Morgenstern Christina , Eckl-Dorna Julia , Schepelmann Martin 
Published: September 2024

AbstractThe Artemisia (mugwort) pollen season usually ranges from July until September, with one peak period around mid-August in Vienna (Austria). During the last decade, Artemisia pollen was also recorded later in September. This pattern was concluded by a significant peak pollen concentration day in autumn of 2023, which exceeded the usual summer peak pollen concentration day. The Artemisia pollen data from Vienna for the last ten years (2014–2023) were therefore analysed for a temporal trend. In addition, weather data from Vienna (temperature, precipitation, and relative humidity and sun hours) were retrieved and analysed to find a possible association with Artemisia pollen indices. No significant trend could be observed regarding the Artemisia pollen season parameters and no correlation was found between the weather data and the Artemisia pollen integrals during summertime. However, a significant positive correlation was found between higher temperatures during autumn and the occurrence of Artemisia pollen during this time. This suggests that a significant change in the Artemisia pollen season can be expected during years with a mild, summer-like autumn. Until now, it is not clear which species of Artemisia cause the pollination in autumn. A. annua and A. verlotiorum are two major suspects that could have established themselves in Vienna, but further evidence is needed. Considering the impact of global climate change, the shift in the pollen season for Artemisia described in this study could represent a point of no return.
Leveraging interpretable machine learning in intensive care
Authors: Bohlen Lasse , Rosenberger Julian , Zschech Patrick , Kraus Mathias 
Published: September 2024

AbstractIn healthcare, especially within intensive care units (ICU), informed decision-making by medical professionals is crucial due to the complexity of medical data. Healthcare analytics seeks to support these decisions by generating accurate predictions through advanced machine learning (ML) models, such as boosted decision trees and random forests. While these models frequently exhibit accurate predictions across various medical tasks, they often lack interpretability. To address this challenge, researchers have developed interpretable ML models that balance accuracy and interpretability. In this study, we evaluate the performance gap between interpretable and black-box models in two healthcare prediction tasks, mortality and length-of-stay prediction in ICU settings. We focus specifically on the family of generalized additive models (GAMs) as powerful interpretable ML models. Our assessment uses the publicly available Medical Information Mart for Intensive Care dataset, and we analyze the models based on (i) predictive performance, (ii) the influence of compact feature sets (i.e., only few features) on predictive performance, and (iii) interpretability and consistency with medical knowledge. Our results show that interpretable models achieve competitive performance, with a minor decrease of 0.2–0.9 percentage points in area under the receiver operating characteristic relative to state-of-the-art black-box models, while preserving complete interpretability. This remains true even for parsimonious models that use only 2.2 % of patient features. Our study highlights the potential of interpretable models to improve decision-making in ICUs by providing medical professionals with easily understandable and verifiable predictions.
Diptera as predators in biological control: applications and future perspectives
Authors: Burgio Giovanni , Dindo Maria Luisa , Pape Thomas , Whitmore Daniel , Sommaggio Daniele 
Published: September 2024

Abstract
The role of dipteran predators in biological pest control programs is reviewed and discussed. Diptera encompasses a large number of potentially efficient predators for biological pest control, yet only a few species are routinary used. The families Syrphidae and Cecidomyiidae provide some of the most successful examples of biological control, but other families (e.g., Muscidae, Sarcophagidae, Sciomyzidae) also include species with that potential. Most applications of Diptera as predators involve the conservation biological control approach, while the augmentative approach has involved only a few species, almost exclusively of Syrphidae and Cecidomyiidae. In a few cases, classical biological control has been employed. Commercialization of species mainly to be used in the augmentative approach is discussed, also focusing on the critical issues linked to rearing methods. The dual services performed by Diptera (pollination as adults and biological control as larvae) have been studied in detail for Syrphidae only, but would deserve further study in other families, e.g., Sarcophagidae. This is the first review in which the use of predatory Diptera in biological control programs is investigated for all families and in all types of applications. This review recommends a multi-taxon approach in the use of Diptera in biological control since a large number of taxa have considerable potential, although this has not yet been tested in practical applications.
Aerial dispersion of Xanthomonas fragariae during trimming leaves of angular leaf spot diseased strawberry propagation plants
Authors: Kastelein P. , Evenhuis A. , Krijger M. C. , van der Wolf J. M. 
Published: September 2024

Summary
The bacterium Xanthomonas fragariae is the causative agent of angular leaf spot (ALS) of strawberry, a Regulated Non-Quarantine Pest in Europe (EPPO A2) for plant propagation material. Field experiments were conducted to explore if X. fragariae is dispersed through the air during trimming ALS-diseased strawberry plants with dry or wetted leaves. Trimming the leaves led to dissemination of leaf fragments to the nearby surroundings. A sharp decrease in the amount of leaf fragments within the first 5 m distance downwind from the strawberry plants was found. Furthermore, air quality monitors demonstrated that during trimming 0.5 – 10 μm sized particles were ejected into the air, resulting in short periods with increased particle densities 45 cm above ground level, which could be detected at least 50 m downwind. At this height X. fragariae was detected by means of air samplers, as evidenced with a combination of dilution-plating and TaqMan assays, at 25 m distance downwind from ALS-diseased plants. A sharp decrease in the density of X. fragariae colony forming units (cfu) within the first 10 m distance from the source plants was found. The densities of X. fragariae cfu were strongly associated with the particle densities. Results indicate that during trimming leaves of strawberry propagation crops with ALS-diseased plants there is a considerable risk of deposition of airborne X. fragariae inoculum on nearby nursery beds. Whether this airborne inoculum can result in infections is discussed.
Baseline survey of environmental parameters, radiation, and drip water hydrochemistry in Niah Caves (Sarawak, Malaysia)
Authors: Mohan Viswanathan Prasanna , Dodge-Wan Dominique 
Published: September 2024

AbstractRelict caves in fenglin karst may typically have numerous entrances and openings. Hence, they host a variety of environments in which parameters such as light, airflow, humidity, and temperature may vary significantly over short distances. Similarly, drip water hydrochemistry, including isotopic values, may vary due to different contributions of various sources and residence time in the karst. This study investigated environmental parameters, including radiation, using hand-held instruments, along a transect within several major caves in the Niah karst of Sarawak (Malaysia). This has led to a baseline data set which showed an inverse relationship between humidity and temperature, gamma radiation levels that are about 25% of that in surrounding non-karst region, and high percentages of twilight zones in the studied caves. Airflow was found to be variable, with high values of 530 m3/s in Painted Cave and 122 m2/s in parts of Gan Kira passage, with flow towards the southeast at the time of the study. The hydrochemistry of the drip water and surface water was also analyzed and found to be dominantly Ca–Mg–Cl water type which indicates dissolution of minerals through water–rock interaction. In addition, the cave environment, particularly air temperature, humidity, and ventilation, also influences the drip water composition and isotopic values. Three different origins (precipitation, evaporation, and paleo-recharge) of drip water have been identified through the δ18O-δ2H diagram. Enriched isotopic values were observed in the cave entrance due to increased evaporation caused by lower humidity and higher air temperature. Factor analysis identifies the key geochemical processes responsible for the drip water chemistry. The outcome of this study provides the first baseline environmental data for the Niah caves, which could support future initiatives for sustainable management of this famous archeological site in southeast Asia.
Parenting in Overdrive: A Meta-analysis of Helicopter Parenting Across Multiple Indices of Emerging Adult Functioning
Authors: McCoy Shelly S. , Dimler Laura M. , Rodrigues Luiza 
Published: September 2024

AbstractPrevious research suggests helicopter parenting may be disproportionately associated with lower levels of adjustment during emerging adulthood. However, the size, direction, and significance of the effects of helicopter parenting across different indicators of emerging adult functioning has not been empirically established. Therefore, the purpose of this meta-analytic investigation was to clarify the magnitude of the effect of helicopter parenting across multiple indices of well-being, including: internalizing behaviors (anxiety and depressive symptoms), academic adjustment, self-efficacy and regulatory skills. We also explored whether parent gender moderates these associations. An analysis of 53 studies and 111 effect sizes revealed that helicopter parenting was associated with increased internalizing behaviors and reduced academic adjustment, self-efficacy and regulatory skills. Parent gender did not moderate these associations. The findings are discussed in terms of future directions, particularly the need to identify potential moderators. In conclusion, these findings support recommendations for autonomy-supportive parenting practices during emerging adulthood.