bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inferring the feeding history of the castor bean tick, Ixodes ricinus from lipid and body measurements
Authors: Udobi Munachimso , Wall Richard 
Published: October 2024

AbstractThe ability to determine when ticks last fed and assign them to a specific feeding cohort is important in attempts to explain their population dynamics; the biochemical measurement of stored lipid, has been widely used for this purpose. However, when relating feeding history to behaviour or infection status, a non‐destructive approach to its assessment would be of value and, to this end, previous studies have attempted to use morphometric indices. Within any instar, the sclerotised scutal components of the body will not vary with increasing starvation while the alloscutal components will, and the resulting ratio should provide a measure of time since feeding. Here, the aim was to determine whether such a morphological ratio (described here as the hunger index) changed predictably with starvation in Ixodes ricinus L. (Ixodida: Ixodidae). For this a cohort of 300 I. ricinus nymphs was collected from the field in February 2021 and starved in a humidified incubator at 15°C and 80% relative humidity (RH). Every 2 weeks, 50 nymphs selected at random were removed and killed by freezing; morphometric measurement was followed by the measurement of lipid using a standard spectrophotometric approach. Both hunger index and stored lipid changed significantly with increasing starvation and were positively correlated with each other. However, the change in morphometric ratio was relatively slight (11%) over 9 weeks and the variation was high. The data suggest therefore that morphological measurements could be used to provide, at best, only broad categorisation of the hunger status of individual I. ricinus ticks in the field.
Consequentialism, Welfarism, and Meaning in Life
Authors: Stevenson Chad Mason 
Published: October 2024

AbstractWhat, if anything, makes a life meaningful? Consequentialist theories about meaning in life maintain that the consequences of that life confer meaning upon it. This article advances one such theory: welfarism about meaning in life. According to this view, a life is conferred meaning if, and only if, and then only insofar as, it promotes or protects the well‐being of other welfare subjects. The purpose of this article is to show why welfarism about meaning in life is the most plausible theory about meaning in life.
God and Time
Authors: Deng Natalja 
Published: October 2024

AbstractThis article introduces the reader to contemporary philosophical research on God and time, without presupposing any familiarity with either philosophy of religion or philosophy of time. To start with, aspects of the topic are compared to some structurally similar ideas in secular philosophical thought about time and ethics. The article then introduces timeless versus temporal conceptions of eternity and discusses positions intending to combine elements of both. There is a brief interlude on relevant background in temporal metaphysics regarding A‐ and B‐theories. The final two sections then examine recent developments in the timeless and temporal camps, with a particular emphasis on the role that temporal metaphysics is playing in discussions of the timeless approach.
The Impact of Video‐Based Educational Intervention on Parents’ Decision to Uptake the Measles–Rubella (MR) Vaccine in Jordan
Authors: Alsaqer Khitam , Kawafha Mariam , Al‐Maghaireh Dua'a , Jallad Samar Thabet , Sheyab Heidar , Al kofahi Abedelkader , Saleh Mayyada 
Published: October 2024

ABSTRACTBackgroundInterventions are needed to decrease measles and rubella (MR) vaccine hesitancy/refusal among Jordanian parents during the implementation campaign in Jordan by 2023. This study developed an educational video for parents with hesitancy or refusal to enhance their attitudes and decisions toward the MR vaccine.ObjectiveThis study aimed to assess the impact of video‐based educational intervention on the attitudes of parents toward the MR vaccine and the decision to accept the MR vaccine.MethodOne group pretest–posttest experimental design was used. A 5‐min MR vaccine education video was shown to parents. Parents' decisions on the MR vaccine and the parent attitudes about childhood vaccines (PACV) scale were collected before, immediately, and 2 weeks after the video, the differences in the scores were also measured.ResultsThe initial PACV scale score averaged 24 ± 1.5. After watching the MR education video, the PACV scores immediately and after 2 weeks were 21 ± 1.6 and 21.8 ± 1.4, respectively, with a statistically significant difference (p value < 0.05). The parents' likelihood of refusing the MR vaccine decreased immediately and 2 weeks after watching the video (68% and 70.5%; respectively), and this decrease was sustained after 2 weeks (p value = 0.617).ConclusionAn educational video intervention was associated with improved PACV and improved parents' attitudes toward the MR vaccine, potentially altering the decisions of hesitant or refusing parents to accept the vaccine during the 2023 MR vaccine campaign in Jordan. These positive effects appeared to persist even 2 weeks after the intervention.
Evaluating paternalism in redress programs
Authors: Winter Stephen , Wilkinson Martin 
Published: October 2024

AbstractThe number of monetary redress programs for survivors of nonrecent abuse in out‐of‐home care is growing. These programs help make monetary remedies more accessible to survivors. However, the reasons that justify these programs also encourage policy makers to adopt paternalistic measures. This article argues that most paternalistic restrictions are unjustified because they infringe on survivors' autonomy without clearly benefiting them.Related ArticlesKahn‐Nisser, Sara. 2018. “Constructive Criticism: Shaming, Incentives, and Human Rights Reforms.” Politics & Policy 46(1): 58–83. https://doi.org/10.1111/polp.12240.Winter, Stephen. 2020. “Tools for Tragedy: Procedures for Assessing Historic Redress Claims.” Politics & Policy 49(1): 162–85. https://doi.org/10.1111/polp.12385.Woessner, Matthew, and April Kelly‐Woessner. 2006. “Slavery Reparations and Race Relations in America: Assessing How the Restitutions Debate Influences Public Support for Blacks, Civil Rights, and Affirmative Action.” Politics & Policy 34(1): 134–54. 10.1111/j.1747‐1346.2006.00007.x.
“Parole, parole”: Unveiling the narrative framework of EU research and innovation projects
Authors: Cerinšek Gregor , Podjed Dan 
Published: October 2024

AbstractThis article examines the narrative framework in European Union (EU) research and innovation projects, focusing on symbolic practices and terminology. The analysis includes over five years of ethnographic research, and 20 European projects funded by Horizon 2020, Horizon Europe, and Erasmus+ programs. It explores different ways project actors internalize and reproduce the EU's symbolic power through its policies, particularly the ambiguous concept of “innovation.” Using Bourdieu's theory of practice, the research highlights the way social structures within the “project field” influence dynamics and outcomes, often resulting in a gap between rhetoric and reality. The study also uncovers broader political and social implications of these practices, calling for critical reflection of their impact. In its conclusion, the authors discuss the challenges of maintaining genuine innovation amidst bureaucratic requirements and the EU's symbolic power, advocating for more nuanced and context‐aware project practices.Related ArticlesKanol, Direnç. 2022. “Narrative Strategies for Emerging Disruptive Technologies: A Case Study of Blockchain for Europe.” Politics & Policy 50(5): 952–66. https://doi.org/10.1111/polp.12492.Nowlin, Matthew C., Maren Trochmann, and Thomas M. Rabovsky. 2022. “Advocacy Coalitions and Political Control.” Politics & Policy 50(2): 201–24. https://doi.org/10.1111/polp.12458.Von Malmborg, Fredrik. 2023. “Combining the Advocacy Coalition Framework and Argumentative Discourse Analysis: The Case of the ‘Energy Efficiency First’ Principle in EU Energy and Climate Policy.” Politics & Policy 51(2):222–41. https://doi.org/10.1111/polp.12525.
Devaluation of Work and Its Linkage With Worker Risks in the Recent Transformation of the Work Sphere
Authors: Titarenko Larissa G. , Karapetyan Ruben V. 
Published: October 2024

ABSTRACTOver the last decades, sociologists of work have paid increasing attention to the critical phenomena in the labor market, among them the devaluation of work and its factors. Based on an analysis of publications in the field, this paper outlines problems of transforming work meanings and values, including their linkage with new worker risks and job security caused by the rapid work changes, precarization, social inequality, growing population gap between the advanced and developing countries, global pandemics, climate crisis and the like. These phenomena reflect social, economic, political, and legal changes and their impact on the sphere of work. Current work challenges have initiated research discussions in the work sphere that have helped spotlight the ongoing transformation of work meanings/values. The article reviews the diversity of theoretical approaches and practical implications of work values transformation from the perspective of factors determining long‐lasting shifts in work values, ranging from recognizing the intrinsic meanings of work to the predominance of pragmatic, instrumental work attitudes. The authors identified three main types of transforming work values based on a systematic mapping of publications. First, the prevalence of material, pragmatic values almost does not leave space for the social value of work. Second, it is the perception of work as a meaningless activity that cannot contribute to work satisfaction. Third, it is a vision of a society without work. When describing these types, the authors outline the transformation of work into an ordinary market product that has lost its intrinsic value and become a source of frustration, alienation, and psychological stress for workers. Diversity of work values reflects the controversial processes related to the global transformation of labor from the growth of innovative potential of some professions to the fear of technological unemployment and new risks for others.
Genomic signatures of inbreeding and mutation load in tree ferns
Authors: Yi Huiqin , Wang Jing , Dong Shiyong , Kang Ming 
Published: October 2024

SUMMARYFerns (Pteridophyta), as the second largest group of vascular plants, play important roles in ecosystem functioning. Homosporous ferns exhibit a remarkable range of mating systems, from extreme inbreeding to obligate outcrossing, which may have significant evolutionary and ecological implications. Despite their significance, the impact of genome‐wide inbreeding on genetic diversity and mutation load within the fern lineage remain largely unexplored. In this study, we utilized whole‐genome sequencing to investigate the genomic signatures of inbreeding and genetic load in three Alsophila tree fern species. Our analysis revealed extremely high inbreeding in A. spinulosa, in contrast to the predominantly outcrossing observed in A. costularis and A. latebrosa. This difference likely reflects divergent mating systems and demographic histories. Consistent with its extreme inbreeding propensity, A. spinulosa exhibits reduced genetic diversity and a pronounced decline in effective population size. Comparison of genetic load revealed an overall reduction in deleterious mutations in the highly inbred A. spinulosa, highlighting that long‐term inbreeding may have contributed to the purging of strongly deleterious mutations, thereby prolonging the survival of A. spinulosa. Despite this, however, A. spinulosa carries a substantive realized genetic load that may potentially instigate future fitness decline. Our findings illuminate the complex evolutionary interplay between inbreeding and mutation load in homosporous ferns, yielding insights with important implications for the conservation and management of these species.
Exploring an economic and highly efficient genetic transformation and genome‐editing system for radish through developmental regulators and visible reporter
Authors: Yi Xiaofang , Wang Congcong , Yuan Xiaoqi , Zhang Mi , Zhang Changwei , Qin Tiaojiao , Wang Haiyun , Xu Liang , Liu Liwang , Wang Yan 
Published: October 2024

SUMMARYRadish (Raphanus sativus L.) is one of the most important root vegetable crops worldwide. However, gene function exploration and germplasm innovation still face tremendous challenges due to its extremely low transformation efficiency. Here, an economic and highly efficient genetic transformation method for radish was explored by Agrobacterium rhizogenes‐mediated transformation with the help of combining special developmental regulator (DR) genes and the visual identification reporter. Firstly, the RUBY gene, a betalain biosynthesis system, could result in a visual red‐violet color used as a convenient and effective reporter for monitoring transgenic hairy roots screening of radish. However, the hairy roots‐to‐shoots conversion system of radish still stands as a barrier to the obtainment of whole transgenic plants, although different hormone combinations and various culture conditions were tried. Following, two DR genes including Wuschel2 (Wus2) and isopentenyl transferase (ipt), as well as their combination Wus2‐ipt were introduced for the shoot regeneration capacity improvement. The results showed that the transgenic shoots could be directly generated without externally supplying any hormones in the presence of a Wus2‐ipt combination. Then, Wus2‐ipt along with the RUBY reporter was employed to establish an efficient genetic transformation system of radish. Moreover, this system was applied in generating gene‐edited radish plants and the phytoene desaturase (RsPDS) gene was effectively knockout through albino phenotype observation and sequencing analysis. These findings have the potential to be widely applied in genetic transformation and genome‐editing genetic improvement of other vegetable species.
Comparison of sedation and general anesthesia protocols for 18F‐FDG‐PET/CT studies in dogs and cats: Musculoskeletal uptake and radiation dose to workers
Authors: Belotta Alexandra F. , Beazley Shannon , Hutcheson Matthew , Mayer Monique , Beaufrère Hugues , Sukut Sally 
Published: October 2024

AbstractIn veterinary medicine, PET/CT scans are generally performed with the patient under general anesthesia. The aim of this prospective crossover study was to compare the musculoskeletal uptake of 18F‐FDG and radiation doses to workers during PET/CT studies of healthy dogs and cats between sedation and general anesthesia. Volume and maximal standard uptake values (SUVmax) values of abnormal 18F‐FDG uptake in the skeletal musculature, presence of misregistration artifact, and radiation doses to workers for each PET/CT study were recorded. Sedation was associated with increased volume of 18F‐FDG uptake in the musculature of the thoracic limbs (p = .01), cervical (p = .02), and thoracic (p = .03) spine. Increased volume and SUVmax of the musculature assessed altogether were associated with the lighter degree of sedation (p = .04 for both). A significant decrease in the odds of misregistration artifact was observed for anesthetized animals in comparison with sedated (OR: 0.0, 95% CI: 0.0–0.0, p = .01). Radiation doses to workers were significantly higher for sedation compared with general anesthesia (p = .01) and for the anesthesia technician compared with the nuclear medicine technologist (p = .01). Use of sedation for PET/CT studies in dogs and cats is feasible. However, it is associated with increased physiologic musculoskeletal uptake of 18F‐FDG in the thoracic limbs, cervical, and thoracic spine, with increased frequency of misregistration artifact, and with increased radiation doses to workers. These limitations can be overcome by recognition of the uptake pattern and monitoring/rotation of the involved staff at institutions where a high caseload is expected.
Fuzzy-PID and interpolation: a novel synergetic approach to process control
Authors: Jha Devashish , Ahmed Arifa , Kumar Sanatan , Roy Debanjan 
Published: October 2024

This paper presents a novel approach for tuning a fuzzy-based proportional-integral-derivative (PID) controller to enhance the control performance of a chemical process control system. The proposed approach combines the advantages of fuzzy- PID and interpolation to achieve improved control performance. Properly tuned PID controllers can help maintain process stability, minimize deviations from setpoints, and ensure efficient operation in industrial systems. Fuzzy logic allows for the incorporation of expert knowledge and linguistic rules, enabling the controller to handle uncertain and imprecise process information. Fuzzy PID controllers combine fuzzy logic and conventional PID control to enhance control performance, particularly in systems with complex or nonlinear dynamic such as chemical plant. It dynamically adjusts the PID parameters—proportional gain (Kp), integral gain (Ki), and derivative gain (Kd)—based on error e(t) and change of error Delta e(t). Interpolation plays a crucial role in this context by filling in the gaps or handling situations not explicitly covered by the fuzzy rules. Comparative studies are conducted to evaluate the performance of the fuzzy PID controller against conventional PID controllers and other advanced control techniques. It is demonstrated that the synergy between fuzzy logic and interpolation not only enhances control performance but also offers a more intuitive and adaptable solution for addressing the complexities of modern chemical process control systems.
Fatigue Scattering Analytics and Prediction of SS 316L Fabricated by Laser Powder Bed Fusion
Authors: Kousoulas Panayiotis , Guo Y. B. 
Published: October 2024

Abstract
Laser powder bed fusion (LPBF) is an enabling process manufacture of complex metal components. However, LPBF is prone to generate geometrical defects (e.g., porosity, lack of fusion), which causes a significant fatigue scattering. However, LPBF fatigue scattering data and analysis in the literature are not only sparse and limited to tension-compression mode but also inconsistent. This article presents a robust high-frequency fatigue testing method to construct stress-cycle curves of SS 316L to understand the scattering nature and predict the scattering pattern. A series of bending fatigue tests are performed at different stress amplitudes. Two different runout criteria are used to investigate fatigue life, fatigue limits, and scattering. The endurance limit reaches around 300 MPa for the defect size distribution at the selected process space. The defect size-based fatigue limit model is found to underestimate the endurance limit by about 30 MPa when comparing with the experimental data. Fatigue scattering is further calculated by using 95% prediction intervals, showing that low fatigue scattering is present at high stresses while a large variation of fatigue life occurs at stresses near the knee point.
Minimum-Time Control of a Linear System With Input Saturation: A Practical Approach
Authors: Sinha Alok 
Published: October 2024

Abstract
A simple algorithm is presented to find near-minimum-time control inputs for a controllable continuous-time linear time-invariant system with any number of states and inputs. The well-known digital deadbeat control algorithm is modified to satisfy input constraints, and the design issue is the selection of sampling period to minimize the time required to reach the desired final state. During each sampling period, the input required to place all the poles at the origin of z-plane (deadbeat control) via state feedback is computed. If the infinity norm of the deadbeat input exceeds the input constraint, the input is found by placing the poles as close to the origin as possible. A sufficient condition for the system stability is developed. Numerical examples illustrate that this algorithm can lead to true time-optimal control or near time-optimal control.
Overcoming amphotericin B resistance in
Candida auris
using the antiemetic drug rolapitant
Authors: Salama Ehab A. , Elgammal Yehia , Utturkar Sagar M. , Lanman Nadia A. , Hazbun Tony R. , Seleem Mohamed N. 
Published: October 2024

ABSTRACT

The emergence of
Candida auris
poses a significant health challenge that has led to a new era of multidrug-resistant fungal infections. Invasive infections caused by
C. auris
are usually associated with remarkable morbidity and mortality. For many years, amphotericin B (AmB) remained the most efficient and the last line of treatment against most hard-to-treat fungal infections. However, strains of
C. auris
possess extraordinary resistance to most antifungal agents, including AmB. In this study, we screened ~2,600 FDA-approved drugs and clinical compounds to identify the antiemetic drug rolapitant as a promising enhancer to AmB against
C. auris
. Rolapitant exhibited potent synergistic interactions with AmB against all tested (29/29)
C. auris
isolates. In a time-kill assay, rolapitant restored the fungicidal activity of AmB within 4 h. Additionally, the synergistic relationship between rolapitant and AmB was observed against other medically crucial
Candida
,
Cryptococcus,
and
Aspergillus
species. A transcriptomic study revealed that exposure to rolapitant affects oxidation reduction processes, ion transporters, and ATP production. Rolapitant triggers an elevation in cytosolic and mitochondrial calcium levels and induces oxidative stress within fungal cells. An ATP luminescence assay confirmed that rolapitant, at sub-inhibitory concentrations, significantly interfered with ATP production in
C. auris
. Moreover, rolapitant enhanced the
in vivo
activity of AmB in a mouse model of disseminated
C. auris
infection, as the combination reduced the fungal burden in murine kidneys by ~1 log (~90%) colony forming units. Our findings warrant further investigation of using rolapitant to overcome AmB resistance in
C. auris
and other fungal species.
Overexpression of β-lactamase genes (
bla
KPC,
bla
SHV
) and novel CirA deficiencies contribute to decreased cefiderocol susceptibility in carbapenem-resistant
Klebsiella pneumoniae
before its approval in China
Authors: Hong Hanxu , Fan Linping , Shi Wenbo , Zhu Yuchen , Liu Peng , Wei DanDan , Liu Yang 
Published: October 2024

ABSTRACT

Cefiderocol (FDC) is an effective antibiotic that is used to treat severe infections caused by carbapenem-resistant
Klebsiella pneumoniae
(CRKP). The mechanisms underlying FDC resistance and molecular epidemiology in China remain unclear. We collected 477 non-duplicate CRKP clinical isolates in central China and characterized their susceptibility to FDC, virulence genes, and sequence typing. The overall FDC susceptibility rate of CRKP was 99.2% in central China, which was higher than that in North America and Europe (96.1%), with MIC
50/90
values of 1/2 mg/L. The decrease in FDC susceptibility in central China was concentrated in the ST11 CRKP-carrying virulence plasmids. Whole-genome sequencing (WGS) and quantitative reverse transcription PCR (qRT-PCR) experiments showed that serine β-lactamases, especially highly expressed KPC and SHV, substantially decreased FDC susceptibility in four FDC non-susceptible isolates (two resistant and two intermediate isolates). Notably, different CirA deficiencies, p.E450GfsTer16 and p.E133Ter, were found in both of the resistant isolates. In contrast, global WGS data indicate that the resistance mechanisms in North America and Europe were primarily associated with NDM and KPC variants, predominantly found in ST307 and ST147. Overall, FDC exhibits excellent activity against CRKP in central China, with resistance mechanisms primarily related to high KPC and SHV expression, along with deficiencies in CirA, frequently observed in ST11. This is remarkably different from the situation in North America and Europe and will directly impact the choice of clinical interventions. Additionally, the surveillance of FDC resistance in China is imperative.