bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACUTE MYOCARDITIS IN THE MAGNETIC RESONANCE IMAGING ERA: PATIENT’S CHARACTERISTICS AND MID-TERM FOLLOW-UP.
Authors: Karam Carma , Alghamdi Ali , Mansencal Nicolas , Binsse Stephen , Lacombe Pascal , Dubourg Olivier 
Published: April 2016

Background: Myocarditis is an inflammation of myocardial tissue that presents with a wide range of symptoms. Cardiovascular magnetic resonance (CMR) has become the first choice of non-invasive assessment of myocardial inflammation in suspected pts. Aims: The aim of this study was to report clinical, paraclinical and follow up data observed in pts with acute myocarditis confirmed by CMR in a single center. Methods: We retrospectively studied27 pts admitted for acute myocarditis between November 2010 and November 2012. All pts had ECG, echocardiography and CMR. Ultrasensitive cardiac troponin and CRP were measured. Coronary angiogram was performed in case of acute myocardial infarction-like syndrome or in the presence of CV risk factors. We reviewed the files of the hospital out-patient clinic and contacted the pts or their cardiologists by phone for those followed outside the hospital. Results: There were 23 males (85.2%) and 4 females, aged 36 ± 19 yrs. ST elevation was found in17 pts (62.9%). All had elevated cardiac troponin. Echocardiography showed abnormalities of wall motion in16 pts (59.2%). Mean LVEF on CMR was 53.96 ± 9.9% and late gadolinium enhancement was in lateral in 80%, in inferior in 10% and anterior or apical wall in 10%. Coronary angiogram was normal, performed in14 pts (51.8%). Complications included VT in4 pts (14.8 %), AF in 2, and cardiac tamponade in 1. Follow-up was obtained for23 pts (85%).One died for pulmonary embolism on lung cancer. All others had a favorable evolution. Conclusion: Our study showed that myocarditis affects in majority young and male patients. CMR appears as the main modality of diagnosis. Coronary angiogram is mandatory in case of CV risk factors and/or myocardial infarction-like presentation. Evolution is often favorable. Optimal medical therapy is still to be defined. Pts can be considered as cured in the absence of chest pain and in case of normalization of echocardiography and/or CMR at follow-up.
KNOWLEDGE, ATTITUDES AND PRACTICES FOR PREVENTION OF STDS AND EARLY PREGNANCY IN ADOLESCENTS FROM A PUBLIC SCHOOL IN SALVADOR, BAHIA
Authors: Lins Liliane , Jesus Santos Ramona De , Hirakawa Vieira Yuki Tany 
Published: April 2016

The aim of this study was to describe the knowledge, attitudes and practices of adolescents in relation to Sexually Transmitted Diseases and adolescent pregnancy prevention. This study enrolled 164 students from a public school in Salvador, Bahia, Brazil. An anonymous questionnaire was developed by the authors and used for data collection. Women comprised 59.5% of the study population and the average age was 17 years old. Only 23% and 34% of the students indicated HBV and HTLV as STDs, respectively. HIV was identified as STD by 84.5% of the students, while 68.3% believed that the disease could be transmitted through blood donation. Only 64.6% of the students reported consistent condom use. Hormonal contraceptive methods were identified by students as a preventive method to STD. The students' knowledge about the theme of the study showed to be unsatisfactory. Attitudes and practices of students can contribute to greater exposure to STD.
MICROALBUMINURIA IS NOT ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN OBESE AND OVERWEIGHT WOMEN, BUT IS STRONGLY CORRELATED WITH FASTING GLYCEMIA
Authors: Bagano Menezes Rômulo , Ribeiro Sampaio Raphael , Guimarães Armênio , Lima Olivieri Lucas , Lourdes Lima Maria De , Marice Ladeia Ana 
Published: April 2016

This study aimed to evaluate the association between endothelial dysfunction and microalbuminuria levels in overweight and obese women. Methods: This cross-sectional study analyzed secondary data of patients with BMI ≥ 25 Kg/m2 who had microalbuminuria and endothelial function test already performed and inserted into the survey database. The endothelial function was evaluated by reactive hyperemia test (endothelium-dependent vasodilation). Results: This study included 41 women aged of 53 ­± 11 years, BMI of 32.56 ± 5.06 Kg/m2, WC of 100.36 ± 23.21 cm. There was no correlation between microalbuminuria and endothelial function. A multivariate logistic regression analysis identified glucose fasting (β = 0.804; p < 0,00,1) and HDL (β = - 0.309; p = 0.048) levels as independent predictors of microalbuminuria. Conclusion: Microalbuminuria is not useful as a marker of subclinical atherosclerosis in this population, however can be associated to glucose fasting and HDL levels.
A RESTRICTED GLÚTEN AND CASEIN DIET FOR THE TREATMENT OF AUTISM: WHAT ARE PARENTS LOOKING FOR? – DIET AND AUTISM
Authors: Penalva Costa Serra Juliane , Pereira Pondé Milena , Ramos Daltro Mônica , Oliveira Celestino Meline Ivone , Machado Junior Samuel Bezerra 
Published: April 2016

This study aims to understand parents perceptions of the importance of restricted glúten and casein diet for the treatment of autism. The study sample consisted of mothers and teachers of five children / adolescents with autism. All the mothers reported some improvement in the children due to the diet, while teachers attributed any improvement to their own work or family support. Only one of the mothers related the search for a diet as treatment to a specific explanatory model for the disease. For mothers, the difficulties of their children leads to a sense of frustration and impotence facing autism. It remains, however, hope, revealed by the search for therapeutic options, which is expressed by the demand of the diet. Teachers highlighted the potential of these children and their positive development with the pedagogical work. Both mothers and teachers highlighted their lack of knowledge regarding the cause of autism. Diet appears as one more form of treatment in the quest of mothers searching for improvement in their autistic children, despite lacking a connection to a specific explanatory model about the disease for the vast majority of mothers.
TYPE 2 DIABETES MELLITUS PREVENTION – PRESCRIPTIONS OFF-LABEL
Authors: De Oliveira Andrade Luis Jesuino , Santana de Melo Paulo Roberto , Alves Silva Margotto Mércia , Vinhaes Bittencourt Alcina Maria 
Published: April 2016

The prescribing a drug without the indications for which the drug was originally approved by regulators is internationally known as prescribing “off-label”. Objective: To describe the off-label prescriptions in type 2 diabetes (DM2) prevention, reported international scientific literature, through an integrative bibliographical review. Method: An integrative review was made by searching the Medline international database for review of manuscripts. Selection of these databases was based on the wide range of journals covered by each of them and our goal was to provide an overview of the scientific production devoted to the topic over the timeframe under analysis. The following inclusion criteria were considered during the review: articles published between January 1985 and June 2013; use of the keywords “off-label use” OR “off-label” OR “off-label prescribing” OR “diabetes prevention” OR “prevention” MeSH “diabetes mellitus” entered into the search form, and availability of an abstract in English. Results: A total 852 scientific productions were identified, and 30 studies were selected by contain information about the off-label prescriptions in DM2. Conclusion: The practice of off-label prescribing itself has notable benefits. In some situations, an off-label prescription is the only treatment available to a patient, either because a more targeted drug is does not exist, or because other methods of treatment are ineffective or unavailable due to patient intolerance. In these situations, off-label uses of drugs provide the only chance of restored health.
THYROID HORMONE CELL-MEMBRANE TRANSPORTERS DEFECT: A NOVEL GENETIC SYNDROME OF THYROID HORMONE RESISTANCE
Authors: Da Silva Medeiros Mateus Fernandes , Estrela Ramos Helton 
Published: April 2016

Many studies has confirmed the crucial role of thyroid hormone transporters for TH action in human target cells. The importance was better understood by observing the phenotype in patients harboring mutations of the monocarboxylate transporter 8 (MCT8) gene immediately linked to Allan Herndon-Dudley Syndrome (AHDS), in which severe neurological findings are associated with abnormal Thyroid hormone levels. The disease is X-chromossome linked, with males presenting a homogeneous neurological psychomotor phenotype and mental retardation associated with low serum T4 and elevated T3 levels. The mechanism of disease is still obscure and either the physiopathology as the existent therapeutic options need to be better studied.
EFFECT OF SMOKING ON THE PERIODONTAL MICROSURGERY TECHNIQUE ON THE TREATMENT OF GINGIVAL RECESSION
Authors: Araújo Barbosa Renata De , Dourado Mônica , Azoubel Maria Cecília , Santos Tunes Roberta , Del Peloso Ribeiro Érica , Bittencourt Sandro , Rocha Tunes Urbino Da 
Published: April 2016

This paper aims to evaluate the effects of smoking on periodontal microsurgery technique using the subepithelial connective tissue graft (SCTG) for treatment of gingival recession on smokers. 14 patients nonsmokers and 12 smokers were selected, presenting Miller’s Class I and II gingival recession ≥ 2.0 mm. For both groups, the subepithelial connective tissue graft was used with the aid of a surgical microscope. The clinical parameters of width and height of the gingival recession, height and thickness of keratinized tissue, probing depth and clinical attachment level were evaluated before and six months after surgery. At the end of the study, there were obtained an average percentage of 96.66% of root coverage on nonsmokers and 82.49% on smokers (p=0.03). Complete root coverage was observed in 78,57% and 50% of patients, respectively. Therapy can benefit both groups, but smokers have less favorable outcomes to root coverage with periodontal microsurgery using the SCTG.
NONSYNDROMIC CLEFT LIP AND/OR PALATE. THE ROLE OF FOLIC ACID 30
Authors: Hoshi Ryuichi , Alves Luis Marcelo , Sá Jamile , Peixoto Medrado Alena , Castro Veiga Patricia De , Almeida Reis Silvia Regina de 
Published: April 2016

The nonsyndromic cleft lip and/or palate (NSCL/P) is a common congenital orofacial defect of multifactorial origin with involvement of genetic and nutritional factors. The presence of genetic polymorphisms in enzymes that metabolize folic acid and vitamin supplements used to prevent these anomalies have not yet been well established in the literature. The aim of this study was to conduct a review of the literature about the role of folate and gene polymorphisms in the metabolic pathway of folic acid as regards the occurrence of NSCL/P. We reviewed theoretical material that addressed data on these topics. According to the studies analyzed in the literature, there was no consensus with regard to the protective effect of supplemental folic acid taken in the periconceptional period in the prevention of NSCL/P. The studies that evaluated defects in genes involved in folate metabolism, found an association of some polymorphisms with NSCL/P in different populations.
SPLENIC CYST
Authors: L. Garcia Larissa , L. Lomanto Fernanda , Simões da Rocha Mata Felipe , Mendonça Dilton 
Published: April 2016

Background: Splenic cysts are rare in children. They are classified into primary and secondary, also called pseudocysts. The primary feature capsule and can be congenital, vascular or neoclassical. The diagnosis, in most cases, is incidental because it is asymptomatic clinical status. The diagnosis is confirmed by Ultrasound and / or Computed Tomography (CT) of the abdomen. Case Report: Patient, I.T.S.A, female, 11 years old, complains of increasing abdominal size. The diagnosis of splenic cyst was confirmed with an exploratory laparotomy. The pathology suggests reactive mesothelial hyperplasia. The patient underwent a total splenectomy and recovered without complications. Conclusions: Splenic cysts are incidental findings, most of the times it has been an asymptomatic clinical status. In the clinical case described, the patient showed a significant increase in the abdomen. She underwent exploratory laparotomy and, consequently, total splenectomy, which is the standard treatment in cases of giants splenic cysts.
Antidiabetic Effect of Sargassum wightii and Ulva fasciata in High fat diet and Multi Low Dose Streptozotocin Induced Type 2 Diabetic Mice
Authors: Lucy Mohapatra  , Subrat Kumar Bhattamishra  , Ramachandra Panigrahy  , Sambit Parida  , Premalata Pati  
Published: April 2016

This study was undertaken to evaluate the antidiabetic effect of edible seaweeds Sargassum wightii and Ulva fasciata with an objective to establish these seaweeds as add-on therapy for controlling diabetes. The ethyl acetate extract of Sargassum wightii (EAS) and Ulva fasciata (EAU) at 100 and 200 mg/kg dose was examined for antidiabetic activity in the high fat diet and multi-low-dose streptozotocin induced type 2 diabetic mice. Plasma glucose, oral glucose tolerance test [OGTT], lipid profile, liver and skeletal muscle glycogen content, triglycerides, superoxide dismutase [SOD], body and organ weight was estimated at the end of the study. Consequently, histopathology of liver was also studied. Both EAS and EAU showed significant reduction in plasma glucose level and the area under curve [AUC] of OGTT was significantly (p<0.001) attenuated. The extracts appreciably normalized lipid profile, body and organ weight. At higher doses of both EAS and EAU showed significant (p<0.05) improvement in SOD level of skeletal muscle and reduction in liver as well as skeletal muscle triglycerides. Both the extracts considerably enhanced hepatic and muscle glycogen content. Remarkable improvements were found in the histopathological observations of liver of all the treated groups as compared against the diabetes induced group. The findings suggest that these seaweeds offer a great opportunity to satisfy the food and nutrition requirement for rectifying and controlling diabetes.
IN VIVO AND IN VITRO IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF TOTAL FLAVONOIDS OF ASTRAGALUS
Authors: Guo Ze , Xu Hong-Yan , Xu Lu , Wang Sha-Sha , Zhang Xue-Mei , Zhang Xue-Mei 
Published: April 2016

Background: Astragali Radix has long been used to improve immune function in traditional Chinese medicine. However, its main
active components and potential immunomodulatory or anti-inflammatory activities have not been elucidated. In the present study,
the immunomodulatory and anti-inflammatory activities of total flavonoids of Astragalus (TFA) isolated from Astragali Radix were
evaluated by using in vivo animal models and in vitro cell models.
Materials and Methods: The in vivo immunomodulatory and anti-inflammatory activities of TFA were assessed by measuring
macrophage phagocytic index, delayed type hypersensitivity, serum hemolysin level and immune organ index in mice, ear edema
test in mice, paw edema test in rats, vascular permeability test in mice and granuloma test in rats. The in vitro immunomodulatory
and anti-inflammatory activities of TFA were assessed by examining its effect on cytokine and mediator production in un-stimulated
and LPS-stimulated murine RAW 264.7 macrophages.
Results: The results of in vivo experiments showed that TFA enhanced macrophage phagocytic index, delayed type hypersensitivity,
serum hemolysin level and immune organ index in mice, and attenuated mouse ear edema, rat paw edema, mouse vascular
permeability and rat granuloma formation. The results of in vitro experiments showed that TFA stimulated the production of NO and
cytokine TNF-α, IL-1β, IL-6 and IFN-γ in un-stimulated RAW 264.7 macrophages, and inhibited the overproduction of these
inflammatory mediators in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without exerting cytotoxicity.
Conclusion: These results of this study indicate that TFA have potential immunostimulatory and anti-inflammatory effects.
PRELIMINARY STUDIES ON THE BEHAVIOURAL EFFECTS OF THE METHANOL EXTRACT OF LEONOTIS NEPETIFOLIA LINN STEM IN MICE
Authors: Ayanwuyi Lydia Ojonemile , Kwanashie Helen O. , Hussaini Isa M. , Yaro Abdullahi H. 
Published: April 2016

Background: Leonotis nepetifolia Linn (Lamiaceae) is used in traditional medicine for its calming (tranquilizing) effects. The aim of this
study was to determine whether there is any scientific justification for this use. To achieve this purpose, we investigated the behavioural
effects of the methanol extract of Leonotis nepetifolia stem (37.5, 75 and 150 mg/kg) in mice.
Methods: Acute toxicity studies were carried out on the methanol stem extract of Leonotis nepetifolia to determine the LD50. The
behavioural tests employed were diazepam-induced sleep onset and duration, hole board assay for exploratory activity, mouse beam walk
assay for motor coordination, and the staircase test for the detection of anxiolytic compounds. Preliminary phytochemical screening was
also carried out on the extract.
Results: The intraperitoneal LD50 value was found to be 3.8 g/kg. The results showed that the extract significantly prolonged the duration
of diazepam-induced sleep at the highest dose (150 mg/kg). There was no observable effect on exploratory activity and motor
coordination at the doses tested (37.5, 75 and 150 mg/kg). The extract, however, at 150 mg/kg elicited a significant decrease in the
number of rearings in the staircase test, an effect also observed in the group of mice injected with an anxiolytic dose of diazepam. The
preliminary phytochemical screening revealed the presence of alkaloids, saponins, glycosides and triterpenoids.
Conclusion: The results obtained suggest that the crude methanol extract of Leonotis nepetifolia stem possesses some biologically active
constituents with potential anxiolytic activity and thus may justify its traditional use as a tranquilizer
THE EFFECTS OF OXIDATIVE STRESS ON PHENOLIC COMPOSITION AND ANTIOXIDANT METABOLISM IN CALLUS CULTURE OF COMMON DAISY
Authors: Pehlivan Karakas Fatma , Cingoz Gunce Sahin , Ucar Turker Arzu 
Published: April 2016

Background: Exogenous pretreatment of oxidative stress on callus cultures of Bellis perennis L. (common daisy) induced catalase
(CAT), superoxide dismutase (SOD), total phenolic, total flavonoid, total protein and selected commercial phenolic compounds
production and accumulation.
Materials and Methods: The callus culture obtained from B. perennis pedicel explants was incubated on Murashige and Skoog
medium (MS) containing 10 mM H2O2 or 0 mM H2O2 (for control group) for 10 hours. Twenty phenolic compounds (apigenin,
caffeic acid, p-coumaric acid, gallic acid, genistein, kaempferol, luteolin, myricetin, procyanidin-C1, quercetin, rutin hydrate,
vanillic acid, ferulic acid, salicylic acid, sinapic acid, chlorogenic acid, hesperedin, naringenin, rosmarinic acid and isorhamnetin)
were detected by LC-ESI-MS/MS analysis in methanolic extracts of 10 mM H2O2 and control treatments.
Results: A predominant phenolic compound was chlorogenic acid followed by rutin hydrate, caffeic acid, luteoline, isorhamnetin,
quercetin, myricetin, apigenin, p-coumaric acid and kaempferol. No gallic acid, genistein, procyanidin-C1, vanillic acid, sinapic
acid, hesperidin and naringenin were detected in H2O2 treatment and control groups of B. perennis. The total phenolic contents
estimated were in the order of H2O2 treatment (285.36 μg/g dw) and control (220.79 μg/g dw) groups. The biosynthesis and
accumulation of kaempferol, myricetin, quercetin and isorhamnetin were only determined in H2O2 treatment callus materials. The
H2O2 pretreatment clearly showed in a raise in enzymatic and non-enzymatic antioxidant activities. Finally, a significant positive
correlation between phenolic accumulation and comprehensive activities of CAT, SOD, total phenolic, total flavonoid and proline
was accessible.
Conclusion: The present results suggest that using H2O2 as an elicitor or a stimulant plays a significant enhancement role in special
phenolic molecules biosynthesis and activation of antioxidant metabolism on callus cultures of B. perennis.
ANTIMICROBIAL ACTIVITY OF GYMNOSPERMA GLUTINOSUM (SPRENG.) LESS. (ASTERACEAE) METHANOL EXTRACTS AGAINST HELICOBACTER PYLORI
Authors: Gomez-Flores Ricardo , Espinosa-Ramos David , Quintanilla-Licea Ramiro , BarrÃ³n- Gonzalez MarÃ­a Porfiria , Tamez-Guerra Patricia , Tamez-Guerra Reyes , Rodriguez-Padilla Cristina 
Published: April 2016

Background: Prolonged use of antibiotics may lead to the selection of drug-resistant bacteria; as a result, efforts are being made to identify new and effective antimicrobial agents, particularly, from medicinal plants, against bacterial infections. Antimicrobial activity of Gymnosperma glutinosum against Helicobacter pylori has not yet been reported.
Materials and methods: The antibacterial in vitro effect of Gymnosperma glutinosum methanol leaf extracts against Helicobacter pylori (ATCC 43504) was evaluated in liquid medium by the colorimetric 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay and in solid medium by the colony forming units (CFU) method.
Results: Methanol extracts significantly (p
Well Integrity Estimation of Salt Cements with Application to Long Term Underground Storage Systems
Authors: Teodoriu Catalin , Asamba Peter , Ichim Adonis 
Published: April 2016

Abstract
The new quest for unconventional resources as well as underground storage sector (CO2, air and natural gas) is the achievement of well integrity which is highlighted by the inadequacy of conventional cementing procedures to provide zonal isolation. Knowledge of the mechanism of fatigue in cement and factors that affect it such as the magnitude of the load, strength and composition of the cement, mechanical properties of the cement and pattern of load cycles are important to achieve a realistic design of a cement system subjected to fatigue loading. Finite element investigations help engineers to assess the stress magnitude and evolution for a given well configuration, but when structural calculations for casing-cement system are required, missing input parameters reduce the quality of the results.
In order to obtain reliable data, extensive experimental work using Class G cement with and without salt addition has been performed in order to measure the principal parameters for mechanical structural calculations: compressive and tensile strength, Young modulus, Poison Ratio. The data was measured under room conditions and elevated temperature and pressure. The results were also extrapolated for a time period beyond 60 days. The obtained data is also compared with published values. Several SPE papers showed that excellent data inventory for well cement is needed when mechanical studies on cement, like finite element studies, are required.
This paper will focus on various cement properties required to succsesfull cement an underground storage well by showing the effects of salt concentration on class G cements used as a reference. The results will help fill gaps in the knowledge about the behavior and reliability of NaCl salt cement slurry in cementing jobs by providing extensive data to perform mechanical and rheological calculations. It will similarly aid in the optimization of cement design and represents a source of input data for numerical simulations of well cement performance.
We were able to establish/prove a relationship between salt content and permeability and, moreover, to show that fresh water in contact with set cement may massively change the porosity of the cement. For the first time, public reliable cement properties are systematically collated and compared.