bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Rated Communication-Related Quality of Life of Individuals With Oromandibular Dystonia Receiving Botulinum Toxin Injections
Authors: Page Allyson D. , Siegel Lauren , Jog Mandar 
Published: June 2017

Purpose
In this preliminary study, we examined self-rated communication-related quality of life (CR-QoL) of 10 control participants and 10 individuals with oromandibular dystonia (OMD) and dysarthria receiving therapeutic botulinum toxin (BoNT-A) injections.

Method
Participants with OMD and associated dysarthria self-rated CR-QoL pre- and post- BoNT-A injection using the American Speech-Language-Hearing Association's Quality of Communication Life Scale (ASHA QCL; Paul et al., 2004). Control participants self-rated CR-QoL during a single experimental visit.

Results
Significant differences were found between control participants and participants with OMD on ratings of CR-QoL across all 5 domains and subdomains of the ASHA QCL. No significant differences in CR-QoL were found over the course of the BoNT-A treatment cycle.

Conclusions
CR-QoL was rated lower by participants with OMD as compared with control participants across all ASHA QCL domains/subdomains with “socialization/activities” and “confidence/self-concept” having the largest effect sizes. No differences in CR-QoL were found over the course of the treatment cycle. We advocate for outcome measures that include patient report. The use of patient-reported outcome measures in conjunction with objective or impairment-based outcome measures can help inform meaningful clinical indicators of treatment success. This study adds novel information that may aid our understanding of the experience of living with OMD in this underserviced clinical population.
Internally Versus Externally Cued Speech in Parkinson's Disease and Cerebellar Disease
Authors: Weir-Mayta Phil , Spencer Kristie A. , Eadie Tanya L. , Yorkston Kathryn , Savaglio Sara , Woollcott Chris 
Published: June 2017

Purpose
The purpose of this study was to examine the effects of an internally versus externally cued speech task on perceived understandability and naturalness in speakers with Parkinson's disease (PD) and cerebellar disease (CD).

Method
Sentences extracted from a covertly recorded conversation (internally cued) were compared to the same sentences read aloud (externally cued) by speakers with PD and a clinical comparison group of speakers with CD. Experienced listeners rated the speech samples using a visual analog scale for the perceptual dimensions of understandability and naturalness.

Results
Results suggest that experienced listeners rated the speech of participants with PD as significantly more natural and more understandable during the reading condition. Participants with CD were also rated as significantly more understandable during the reading condition, but ratings of naturalness did not differ between conversation and reading.

Conclusions
Speech tasks can have a pronounced impact on perceived speech patterns. For individuals with PD, both understandability and naturalness can improve during reading tasks versus conversational tasks. The speech benefits from reading may be attributed to several mechanisms, including possible improvement from an externally cued speech task. These findings have implications for speech task selection in evaluating individuals with dysarthria.
Initial Observations of Lingual Movement Characteristics of Children With Cerebral Palsy
Authors: Nip Ignatius S. B. , Arias Carlos R. , Morita Kristen , Richardson Hannah 
Published: June 2017

Purpose
This preliminary study compared the speech motor control of the tongue and jaw between children with cerebral palsy (CP) and their typically developing (TD) peers.

Method
Tongue tip and jaw movements of 4 boys with spastic CP and 4 age- and sex-matched TD peers were recorded using an electromagnetic articulograph during 10 repetitions of “Dad told stories today.” The duration, path distance, average speed, and speech movement stability of the movements were calculated for each repetition.

Results
The children with CP had longer durations than their TD peers. Children with CP had longer path distances and faster average speed as compared with their TD peers for both articulators. The TD group but not the CP group had longer path distances and faster average speeds for the tongue than the jaw. The CP group had reduced speech movement stability for the tongue as compared with their TD peers, but both groups had similar speech movement stability for the jaw.

Conclusions
Children with CP had impaired speech motor control of the tongue and jaw as compared with their TD peers, and these speech motor control deficits were more pronounced in the tongue tip than the jaw.
Impact of Acute Intestinal Ischemia and Reperfusion Injury on Hemodynamics and Remote Organs in a Rat Model
Authors: Wang Meng , Verhaegh Rabea , Tsagakis Konstantinos , Brencher Lisa , Zwanziger Denise , Jakob Heinz , Groot Herbert , Dohle Daniel-Sebastian 
Published: June 2017

Background Acute mesenteric ischemia following cardiovascular surgery is a rare but fatal complication. We established a new rat model for hemodynamic monitoring during mesenteric ischemia/reperfusion (I/R) and evaluated the impact of mesenteric I/R on hemodynamics and remote organ injury.
Methods Mesenteric I/R was induced in male Wistar rats by superior mesenteric artery occlusion for 90 minutes, followed by 120 minutes of reperfusion. Before I/R, ventilation and hemodynamic monitoring including mean arterial blood pressure (MAP) and cardiac output (CO) were established. During reperfusion Geloplasma (I/R + Geloplasma, N = 6) and Ringer's solution (I/R + Ringer, N = 6) were titrated according to CO and compared with I/R without volume resuscitation (I/R only, N = 6) and a sham group (sham, N = 6). Blood samples were regularly taken for serum marker measurements. After reperfusion organs were harvested for histology studies.
Results After acute mesenteric I/R, MAP and CO decreased (p < 0.01) while systemic and pulmonary vascular resistance increased (p < 0.01) continuously in the I/R group. Volume substitution according to CO initially stabilized hemodynamic parameters, but CO declined independently in the late stage. Compared with the I/R + Ringer group, the I/R + Geloplasma group required less volume for resuscitation (p < 0.01), experienced less metabolic acidosis. I/R groups had more organ injuries, more neutrophils sequestration, and higher creatine phosphokinase-MB levels than sham group.
Conclusion A new model for CO monitoring after mesenteric I/R injury demonstrated severe hypovolemic shock during reperfusion followed by remote myocardial and lung injury. Far less colloid volume is needed for hemodynamic stabilization after I/R compared with crystalloid volume.
Groundwater declines are linked to changes in Great Plains stream fish assemblages
Authors: Perkin Joshuah S. , Gido Keith B. , Falke Jeffrey A. , Fausch Kurt D. , Crockett Harry , Johnson Eric R. , Sanderson John 
Published: June 2017

SignificanceNature and society depend on groundwater to sustain aquatic ecosystems and human livelihoods, but local and regional groundwater supplies are dwindling where human water extraction exceeds aquifer recharge. Although groundwater depletion is a global problem, ecological consequences for aquatic species such as fishes are rarely examined. We demonstrate that more than half a century of groundwater pumping from the United States High Plains Aquifer has been associated with collapses of large-stream fishes and expansion of small-stream fishes where hydrologic conditions were altered most. Projections indicate that these habitats will continue to shrink over the next half-century if groundwater pumping practices are not modified. Our findings highlight a mechanism for biotic homogenization with global implications given the worldwide extraction of groundwater.
Aridity and hominin environments
Authors: Blumenthal Scott A. , Levin Naomi E. , Brown Francis H. , Brugal Jean-Philip , Chritz Kendra L. , Harris John M. , Jehle Glynis E. , Cerling Thure E. 
Published: June 2017

Significance
Oxygen isotopes in modern and fossil mammals can provide information on climate. In this study, we provide a new record of aridity experienced by early hominins in Africa. We show that past climates were similar to the climate in eastern Africa today, and that early hominins experienced highly variable climates over time. Unexpectedly, our findings suggest that the long-term expansion of grasses and grazing herbivores since the Pliocene, a major ecological transformation thought to drive aspects of hominin evolution, was not coincident with aridification in northern Kenya. This finding raises the possibility that some aspects of hominin environmental variability might have been uncoupled from aridity, and may instead be related to other factors, such as rainfall seasonality or ecological interactions among plants and mammals.
Disentangling the effects of selection and loss bias on gene dynamics
Authors: Iranzo Jaime , Cuesta José A. , Manrubia Susanna , Katsnelson Mikhail I. , Koonin Eugene V. 
Published: June 2017

SignificanceEvolution of microbes is dominated by horizontal gene transfer and the incessant host–parasite arms race that promotes the evolution of diverse antiparasite defense systems. The evolutionary factors governing these processes are complex and difficult to disentangle, but rapidly growing genome databases provide ample material for testing evolutionary models. Rigorous mathematical modeling of evolutionary processes, combined with computer simulation and comparative genomics, allowed us to elucidate the evolutionary regimes of different classes of microbial genes. Only genes involved in key informational and metabolic pathways are subject to strong selection, whereas most of the others are effectively neutral or even burdensome. Mobile genetic elements and defense systems are costly, supporting the understanding that their evolution is governed by the same factors.
Microfluidic guillotine for single-cell wound repair studies
Authors: Blauch Lucas R. , Gai Ya , Khor Jian Wei , Sood Pranidhi , Marshall Wallace F. , Tang Sindy K. Y. 
Published: June 2017

SignificanceWhereas tissues can repair wounds regularly, single cells—including muscle cells, neurons, and cancer cells—are increasingly recognized to have a wound response. Ability to understand and control single-cell repair holds the potential for new strategies to treat human diseases. Existing wounding methods and model organisms are insufficient for elucidating the biological mechanisms involved. This paper reports a microfluidic guillotine for the high-throughput bisection of hundreds of cells reproducibly. The fine time resolution achieved enables mechanistic studies critical for a molecular understanding of single-cell wound repair currently impossible with existing wounding methods. The work here will lay the foundation for understanding how single cells heal themselves, a fundamental feature distinguishing living from nonliving matter.
Diffusive dynamics during the high-to-low density transition in amorphous ice
Authors: Perakis Fivos , Amann-Winkel Katrin , Lehmkühler Felix , Sprung Michael , Mariedahl Daniel , Sellberg Jonas A. , Pathak Harshad , Späh Alexander , Cavalca Filippo , Schlesinger Daniel , Ricci Alessandro , Jain Avni , Massani Bernhard , Aubree Flora , Benmore Chris J. , Loerting Thomas , Grübel Gerhard , Pettersson Lars G. M. , Nilsson Anders 
Published: June 2017

Significance
The importance of a molecular-level understanding of the properties, structure, and dynamics of liquid water is recognized in many scientific fields. It has been debated whether the observed high- and low-density amorphous ice forms are related to two distinct liquid forms. Here, we study experimentally the structure and dynamics of high-density amorphous ice as it relaxes into the low-density form. The unique aspect of this work is the combination of two X-ray methods, where wide-angle X-ray scattering provides the evidence for the structure at the atomic level and X-ray photon-correlation spectroscopy provides insight about the motion at the nanoscale, respectively. The observed motion appears diffusive, indicating liquid-like dynamics during the relaxation from the high-to low-density form.
Lexical patterns of place in English and Norwegian
Authors: Hasselgård Hilde 
Published: June 2017

Abstract
This paper presents a contrastive analysis of the English noun place and the corresponding Norwegian nouns plass and sted. The study involves two stages. First the patterns of cross-linguistic correspondences of the nouns are established by means of translational data from the English–Norwegian Parallel Corpus. The correspondence patterns reveal both differences and commonalities between the words. Secondly, recurrent lexical bundles involving place, sted, and plass are investigated in order to discover their selectional preferences. The combined approach to the meanings and usage patterns of the words show the two Norwegian nouns to be almost in complementary distribution in many of their patterns. Place is broader in its meaning and shares senses and uses with both of the Norwegian nouns, although in certain contexts sted/plass correspond to different nouns (e.g. room or space), or to adverbs in -where. Certain idiomatic expressions are similar across the languages, but non-literal uses typically do not correspond to a spatial expression in the other language.
Citations in research writing
Authors: Šinkūnienė Jolanta 
Published: June 2017

Abstract
The paper investigates disciplinary, cultural and genre factors and their influence on citation in research writing. The study is based on literature and linguistics research articles written by Lithuanian and British researchers in their native languages as well as literature and linguistics BA papers written by Lithuanian students in English. The focus of the study is on frequency distribution, syntactic integration and types of citations. The results of the study of research articles confirm clear disciplinary variation in the way citations are employed in research writing. No obvious cultural differences were observed in the analysed expert texts, which points towards discipline as a decisive factor in citational trends in literature and linguistics. Citation trends in linguistic and literature BA papers were similar to a certain extent; however, students who wrote literature papers seem to cite more in the manner of professional writers and thus display more similarity with the conventional citational practices of their field.
Induced beliefs about a fictive energy drink influences 200‐m sprint performance†
Authors: de la Vega Ricardo , Alberti Sara , Ruíz‐Barquín Roberto , Soós István , Szabo Attila 
Published: June 2017

AbstractPlacebo and nocebo effects occur in response to subjective expectations and their subsequent neural actions. Research shows that information shapes expectations that, consequently, influence people's behaviour. In this study, we examined the effects of a fictive and inert green colour energy drink provided for three groups (n = 20/group) with different information. The first group was led to expect that the drink augments running performance (positive information), the second group was led to expect that the drink may or may not improve performance (partial‐positive information), while the third group was told that earlier research could not demonstrate that the drink improves performance (neutral/control). At baseline, the three groups did not differ in their 200‐m sprint performance (p > .05). One week later, 20‐min immediately after ingesting the drink, all participants again ran 200 m. The positive information group increased its performance by 2.41 s, which was statistically significant (p < .001) and also perceived its sprint‐time shorter (p < .05) than the other two groups. A better performance (0.97 s) that approached but did not reach statistical significance was also noted in the partial‐positive information group, and a lesser change (0.72 s) that was statistically not significant was noted in the neutral information control group. These results reveal that drinking an inert liquid, primed with positive information, changes both the actual and the self‐perceived time on a 200‐m sprint. The current findings also suggest that the level of certainty of the information might be linked to the magnitude of change in performance.
Bio-Docklets: virtualization containers for single-step execution of NGS pipelines
Authors: Kim Baekdoo , Ali Thahmina , Lijeron Carlos , Afgan Enis , Krampis Konstantinos 
Published: June 2017

Abstract
Processing of next-generation sequencing (NGS) data requires significant technical skills, involving installation, configuration, and execution of bioinformatics data pipelines, in addition to specialized postanalysis visualization and data mining software. In order to address some of these challenges, developers have leveraged virtualization containers toward seamless deployment of preconfigured bioinformatics software and pipelines on any computational platform. We present an approach for abstracting the complex data operations of multistep, bioinformatics pipelines for NGS data analysis. As examples, we have deployed 2 pipelines for RNA sequencing and chromatin immunoprecipitation sequencing, preconfigured within Docker virtualization containers we call Bio-Docklets. Each Bio-Docklet exposes a single data input and output endpoint and from a user perspective, running the pipelines as simply as running a single bioinformatics tool. This is achieved using a “meta-script” that automatically starts the Bio-Docklets and controls the pipeline execution through the BioBlend software library and the Galaxy Application Programming Interface. The pipeline output is postprocessed by integration with the Visual Omics Explorer framework, providing interactive data visualizations that users can access through a web browser. Our goal is to enable easy access to NGS data analysis pipelines for nonbioinformatics experts on any computing environment, whether a laboratory workstation, university computer cluster, or a cloud service provider. Beyond end users, the Bio-Docklets also enables developers to programmatically deploy and run a large number of pipeline instances for concurrent analysis of multiple datasets.
Advanced experimental approaches to marine water-column biogeochemical processes
Authors: Legendre Louis , Rivkin Richard B , Jiao Nianzhi 
Published: June 2017

AbstractThis “Food for Thought” article examines the potential uses of several novel scientific and technological developments, which are currently available or being developed, to significantly advance or supplement existing experimental approaches to study water-column biogeochemical processes (WCB-processes). After examining the complementary roles of observation, experiments and numerical models to study WCB-processes, we focus on the main experimental approaches of free-water in situ experiments, and at-sea and on-land meso- and macrocosms. We identify some of the incompletely resolved aspects of marine WCB-processes, and explore advanced experimental approaches that could be used to reduce their uncertainties. We examine three such approaches: free-water experiments of lengthened duration using bioArgo floats and gliders, at-sea mesocosms deployed several 100s m below the sea-surface using new biogeochemical sensors, and 50 m-tall on-land macrocosms. These approaches could lead to significant progress in concepts related to marine WCB-processes.
Decision Making in Surgery for Nonsaccular Posterior Inferior Cerebellar Artery Aneurysms With Special Reference to Intraoperative Assessment of Collateral Blood Flow and Neurophysiological Function
Authors: Narducci Alessandro , Xu Ran , Vajkoczy Peter 
Published: June 2017

Abstract

BACKGROUND
Posterior inferior cerebellar artery (PICA) aneurysms represent a challenging pathology. PICA sacrifice is often necessary, due to the high proportion of nonsaccular aneurysms that can be found in this location. Several treatments are available, but the infrequency of these aneurysms and the increasing number of endovascular techniques have limited the development of a standardized algorithm for cases in which open surgery is indicated.

OBJECTIVE
We present our series of nonsaccular PICA aneurysms, in the attempt to define an algorithm for their surgical management.

METHODS
We retrospectively reviewed the operation database, identifying patients harboring nonsaccular PICA aneurysms who were surgically treated at our institution from 2007 to 2016.

RESULTS
During a 9-yr period, 17 patients harboring 18 nonsaccular PICA aneurysms were surgically treated at our institution. Fourteen (7.7%) aneurysms were located within the proximal PICA (including those located at the vertebral artery–PICA junction), and 4 were located distally. We performed PICA revascularization in 8 (57.1%) cases of proximal aneurysms (n = 4, PICA–PICA bypass; n = 4, occipital artery–PICA bypass). We based our decision whether to perform bypass on intraoperative test occlusion with indocyanine green (ICG) videoangiography and neurophysiological monitoring. In no cases, bypass was necessary for distal aneurysms.

CONCLUSION
For nonsaccular PICA aneurysms, in which vessel occlusion is often necessary, it is possible to adopt a selective use of revascularization techniques. Intraoperative occlusion test with ICG videoangiography and neurophysiological monitoring provides reliable indications, allowing real-time assessment of collateral circulation.
Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool
Authors: Sileshi Bantayehu , Newton Mark W. , Kiptanui Joash , Shotwell Matthew S. , Wanderer Jonathan P. , Mungai Mary , Scherdin Jon , Harris Paul A. , Vermund Sten H. , Sandberg Warren S. , McEvoy Matthew D. 
Published: June 2017

Abstract

Background
Perioperative mortality rate is regarded as a credible quality and safety indicator of perioperative care, but its documentation in low- and middle-income countries is poor. We developed and tested an electronic, provider report–driven method in an East African country.

Methods
We deployed a data collection tool in a Kenyan tertiary referral hospital that collects case-specific perioperative data, with asynchronous automatic transmission to central servers. Cases not captured by the tool (nonobserved) were collected manually for the last two quarters of the data collection period. We created logistic regression models to analyze the impact of procedure type on mortality.

Results
Between January 2014 and September 2015, 8,419 cases out of 11,875 were captured. Quarterly data capture rates ranged from 423 (26%) to 1,663 (93%) in the last quarter. There were 93 deaths (1.53%) reported at 7 days. Compared with four deaths (0.53%) in cesarean delivery, general surgery (n = 42 [3.65%]; odds ratio = 15.80 [95% CI, 5.20 to 48.10]; P < 0.001), neurosurgery (n = 19 [2.41%]; odds ratio = 14.08 [95% CI, 4.12 to 48.10]; P < 0.001), and emergency surgery (n = 25 [3.63%]; odds ratio = 4.40 [95% CI, 2.46 to 7.86]; P < 0.001) carried higher risks of mortality. The nonobserved group did not differ from electronically captured cases in 7-day mortality (n = 1 [0.23%] vs. n = 16 [0.58%]; odds ratio =3.95 [95% CI, 0.41 to 38.20]; P = 0.24).

Conclusions
We created a simple solution for high-volume, prospective electronic collection of perioperative data in a lower- to middle-income setting. We successfully used the tool to collect a large repository of cases from a single center in Kenya and observed mortality rate differences between surgery types.