bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct histopathologic features of radiation‐induced chronic sinusitis
Authors: Kuhar Hannah N. , Tajudeen Bobby A. , Heilingoetter Ashley , Mahdavinia Mahboobeh , Gattuso Paolo , Ghai Ritu , Gunawan Ferry , Diaz Aidnag Z. , Tolekidis George , Batra Pete S. 
Published: July 2017

BackgroundChronic rhinosinusitis (CRS) is a commonly observed sequela after radiation therapy to the paranasal sinuses. The histopathologic features of radiation‐induced CRS have yet to be determined and may have major implications in disease management.MethodsA structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Histopathology variables, Lund‐Mackay score (LMS), and 22‐item Sino‐Nasal Outcome Test (SNOT‐22) scores were compared among patients with radiation‐induced CRS (CRSr), CRS without nasal polyps (CRSsNP), and CRS with nasal polyps (CRSwNP).ResultsFifteen CRSr, 43 CRSsNP, and 56 CRSwNP patients who underwent FESS were analyzed. Compared with CRSsNP, CRSr cases had increased squamous metaplasia (40.0% vs 9.3%, p < 0.013) and subepithelial edema (53.3% vs. 2.3%, p < 0.001). Compared with CRSwNP, CRSr cases had fewer eosinophils per high‐power field (20.0% vs 50.0%, p < 0.034), less basement membrane thickening (33.3% vs 76.8%, p < 0.002), and fewer eosinophil aggregates (0.0% vs 30.4%, p < 0.009). CRSr had significantly greater mean LMS (13.47 ± 5.13 vs 7.07 ± 4.79, p < 0.001) compared with CRSsNP.ConclusionRadiation‐induced CRS patients exhibited greater squamous metaplasia and subepithelial edema when compared with a cohort of patients with CRSsNP, and decreased eosinophilia and basement membrane thickening compared with a cohort of CRSwNP patients. CRSr cases demonstrated no difference in eosinophilia or neutrophilia compared with CRSsNP, and decreased eosinophilia compared with CRSwNP, lending further credence to the unique nature of radiation in the development of CRS in this patient group. These findings may have major implications with regard to extent of surgical intervention and medical management.
Biomimetic Synthesis of Complex Flavonoids Isolated from Daemonorops “Dragon's Blood”
Authors: Schmid Matthias , Trauner Dirk 
Published: July 2017

AbstractThe dragonbloodins are a pair of complex flavonoid trimers that have been isolated from the palm tree Daemonorops draco, one of the sources of the ancient resin known as “dragon's blood”. We present a short synthesis that clarifies their relative configurations and sheds light on their origin in Nature. This synthesis features biomimetic cascade reactions that involve both ionic and radical intermediates. The biogenetic relationships between dracorhodin, the dracoflavans C, and the dragonbloodins A1 and A2 are discussed.
Emulsion‐electrospinning n‐octadecane/silk composite fiber as environmental‐friendly form‐stable phase change materials
Authors: Zhao Liang , Luo Jie , Li Yu , Wang Hao , Song Guolin , Tang Guoyi 
Published: July 2017

ABSTRACTThe ultrafine n‐octadecane/silk composite fibers as form‐stable phase change materials were successfully developed by the emulsion‐electrospinning method. The effect of n‐octadecane content in the emulsion on the morphology and thermal energy storage capacity of the composite fibers were scientifically investigated. Scanning electron microscopy images show that the composite fibers display cylindrical shape with smooth surface and uniform diameter. Differential scanning calorimetry results demonstrate that the composite fibers exhibit reversible phase transition behavior, high thermal energy storage capacity, and good thermal reliability. Meanwhile, the composite fibers exhibit the capability to regulate their interior temperature as the ambient temperature alters according to the thermo‐infrared images. In addition, the composite fibers are friendly to the environment due to the biodegradability of silk. Therefore, the n‐octadecane /silk composite fibers have the great potential application of serving as form‐stable phase change materials for thermal energy storage and thermal regulation. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45538.
Modulation of Pacific Decadal Oscillation on the relationship of El Niño with southern China rainfall during early boreal winter
Authors: Li Gang , Chen Jiepeng , Wang Xin , Tan Yanke , Jiang Xiaohua 
Published: July 2017

AbstractThe modulation of Pacific Decadal Oscillation (PDO) on the relationship of El Niño with southern China rainfall during early boreal winter (November–December) is investigated in this study. When El Niño occurs in positive phase of PDO, significantly positive rainfall anomalies only appears over the southwestern part of southern China. When El Niño occurs in negative phase of PDO, pronounced positive rainfall anomalies are observed over almost the whole southern China. Further analyses revealed that the anomalous Philippine Sea anticyclone (PSAC) and local meridional circulation play an important role in modulating the relationship of El Niño with southern China rainfall by PDO. During the negative PDO phase, under the combined influence of tropical Pacific and Indian Ocean dipole sea surface temperature anomalies pattern, the anomalous PSAC over the western North Pacific and rising motion associated with local meridional circulation over southern China provide sufficient water vapor and dynamical conditions for the formation of rainfall. During positive PDO phase, however, PSAC and local meridional circulation are only influenced by tropical Pacific and they become weak, not favoring the formation of southern China rainfall.
Bioinformatics analysis in menopause transition promotes distinct modulation in calvaria and bone marrow osteoblastic cells
Authors: Li Chenyu , Wang Yanfei , Luan Hong , Zhang Hui , Xu Yan 
Published: July 2017

AbstractWe read with great interest the recent report by Semeghini et al. (2017), Cell Biol Int, “Menopause transition promotes distinct modulation of mRNAs and miRNAs expression in calvaria and bone marrow osteoblastic cells,” which appeared on 24 May 2017 in Cell Biology International. The results of the report are very helpful for us; however, from our perspective, the author's method in bioinformatics analysis is inappropriate: Student's t‐test is an inappropriate statistical method for detecting differentially expressed mRNA or miRNA in osteoblastic cells from calvaria of ovariectomized rats compared to control or in osteoblastic cells from bone marrow of ovariectomized rats compared to control.
Design and Synthesis of 4‐Alkylidene‐β‐lactams: Benzyl‐ and Phenethyl‐carbamates as Key Fragments to Switch on Antibacterial Activity
Authors: Giacomini Daria , Martelli Giulia , Piccichè Miriam , Calaresu Enrico , Cocuzza Clementina Elvezia , Musumeci Rosario 
Published: July 2017

AbstractThe emergence of multidrug‐resistant bacterial strains is particularly important in chronic pathologies such as cystic fibrosis (CF), in which persistent colonization and selection of resistant strains is favored by the frequent and repeated use of antibacterial agents. Staphylococcus aureus is a common pathogen in CF patients that has an associated increased multidrug resistance. In previous studies we demonstrated that the presence of a 4‐alkylidene side chain directly linked to a β‐lactam appeared to strengthen the potency against S. aureus, especially against methicillin‐resistant S. aureus (MRSA) strains. In the present study, 21 new 4‐alkylidene‐β‐lactams were synthesized and evaluated for antibacterial activity. We designed the new compounds to have aryl, benzyl, or phenethyl‐carbamate groups on the C3 hydroxyethyl side chain. We found a correlation between biological activity and the nitrogen substituent of the carbamate group, and two phenethyl‐carbamate β‐lactams were shown to be valuable antibacterial agents against selected linezolid‐resistant strains, with a minimum inhibitory concentrations of 2–4 mg L−1.
Implications of Crystal Structure on Organotin Carboxylate Photoresists†
Authors: Sharps Meredith C. , Marsh David A. , Zakharov Lev N. , Hutchison James E. , Johnson Darren W. 
Published: July 2017

AbstractA series of five organotin carboxylates of the type [RSn(O)O2CR’]6 containing n‐butyl ligands and carboxylates ranging in size from formate to diphenylacetate were synthesized and examined by single crystal X‐ray diffraction. The crystal and packing structures of each compound were compared with regards to the steric and intermolecular forces of the varying carboxylate groups in order to aid the understanding of how these same factors relate to irradiation trends in EUV lithography of thin films. The trends found are compared to other factors that may also dictate resist formation in order to elucidate a fuller picture of the chemical transformations that occur when patterning inorganic materials.
A secure authentication and key agreement scheme for roaming service with user anonymity
Authors: Arshad Hamed , Rasoolzadegan Abbas 
Published: July 2017

SummaryNowadays, with the advancement of wireless technologies, global mobility networks offer roaming services for mobile users. Since in global mobility networks the communication channel is public, adversaries can launch different security attacks to breach the security and privacy of data and mobile users. Hence, an authentication and key agreement scheme can be used to provide secure roaming services. It is well known that the conventional authentication schemes are not suitable for global mobility networks, because the authentication server of each network has the credentials of its registered users and thus cannot verify the authenticity of the other mobile users. Hence, for providing secure roaming services, another type of authentication called roaming authentication is required. Hitherto, a large number of authentication protocols have been proposed for global mobility networks. However, most of them have been proved to be insecure against various attacks. This paper proposes a secure and efficient authentication and key agreement scheme for global mobility networks. The proposed scheme is based on the elliptic curve cryptosystem. The correctness of the proposed scheme is verified using Burrows‐Abadi‐Needham logic. In addition, the security of the proposed scheme is proved using ProVerif. Detailed analyses demonstrate that the proposed scheme not only withstands various security attacks but also improves the efficiency by reducing the computational costs.
Next‐generation restoration for sage‐grouse: a framework for visualizing local conifer cuts within a landscape context
Authors: Reinhardt Jason R. , Naugle David E. , Maestas Jeremy D. , Allred Brady , Evans Jeffrey , Falkowski Michael 
Published: July 2017

AbstractThe expansion of coniferous trees into sagebrush ecosystems is a major driver of habitat loss and fragmentation, resulting in negative impacts to wildlife. Greater sage‐grouse (Centrocercus urophasianus) respond directly to conifer expansion through decreased breeding activity, nesting, and overall survival; thus, small amounts of conifer expansion can have significant impacts on sage‐grouse habitat and populations. To this end, conservation partners have collaborated across private and public lands to reduce the threat of conifer expansion through targeted removal of conifer trees. Here, we demonstrate the use of the Marxan framework to incorporate important ecosystem attributes in the prioritization of conifer removal within the Oregon range of sage‐grouse. We prioritized conifer removal relative to three separate goals: (1) enhancement of existing sage‐grouse breeding, nesting, and early brood‐rearing habitats; (2) facilitation of sage‐grouse movement between breeding and brood‐rearing habitats; and (3) improvement of connectivity among sage‐grouse priority areas for conservation (PACs). Optimization models successfully identified areas with low conifer canopy cover, high resilience and resistance to wildfire and annual grass invasion, and high bird abundance to enhance sage‐grouse habitat. The inclusion of mesic resources resulted in further prioritization of areas that were closer to such resources, but also identified potential pathways that connected breeding habitats to the late brood‐rearing habitats associated with mesic areas. Examining areas outside ofPACs resulted in the selection of potential corridors to facilitate connectivity; although areas with low conifer cover were selected similarly to the other optimization models, areas with high cover were also chosen to be able to enhance connectivity. Areas identified by optimization models were largely consistent with and overlapped ongoing conifer removal efforts in the Warner Mountains of south‐central Oregon. Land ownership of preferential areas selected by models varied with priority goals and followed general ownership patterns of the region, with public lands managed by the Bureau of Land Management and private lands being selected the most. The increased availability of landscape‐level datasets and assessment tools in sagebrush ecosystems can reduce the time and cost of both planning and implementation of habitat projects involving conifer removal. Most importantly, incorporating these new datasets and tools can supplement expert‐based knowledge to maximize benefits to sagebrush and sage‐grouse conservation.
Recovery free of heart failure after acute coronary syndrome and coronary revascularization
Authors: Falkenham Alec , Saraswat Manoj K. , Wong Chloe , Gawdat Kareem , Myers Tanya , Begum Jahanara , Buth Karen J. , Haidl Ian , Marshall Jean , Légaré Jean‐Francois ,   for the REACH Investigators
Published: July 2017

AbstractAimsPrevious studies have examined risk factors for the development of heart failure (HF) subsequent to acute coronary syndrome (ACS). Our study seeks to clarify the clinical variables that best characterize patients who remain free from HF after coronary artery bypass grafting (CABG) surgery for ACS to determine novel biological factors favouring freedom from HF in prospective translational studies.Methods and resultsNova Scotia residents (1995–2012) undergoing CABG within 3 weeks of ACS were included. The primary outcome was freedom from readmission to hospital due to HF. Descriptive statistics were generated, and a Cox proportional hazards model assessed outcome with adjustment for clinical characteristics. Of 11 936 Nova Scotians who underwent isolated CABG, 3264 (27%) had a recent ACS and were included. Deaths occurred in 210 (6%) of subjects prior to discharge. A total of 3054 patients were included in the long‐term analysis. During follow‐up, HF necessitating readmission occurred in 688 (21%) subjects with a hazard ratio of 12% at 2 years. The adjusted Cox model demonstrated significantly better freedom from HF for younger, male subjects without metabolic syndrome and no history of chronic obstructive pulmonary disease, renal insufficiency, atrial fibrillation, or HF.ConclusionsOur findings have outlined important clinical variables that predict freedom from HF. Furthermore, we have shown that 12% of patients undergoing CABG after ACS develop HF (2 years). Our findings support our next phase in which we plan to prospectively collect blood and tissue specimens from ACS patients undergoing CABG in order to determine novel biological mechanism(s) that favour resolution of post‐ACS inflammation.
Implication of pulmonary hypertension in patients undergoing MitraClip therapy: results from the German transcatheter mitral valve interventions (TRAMI) registry
Authors: Tigges Eike , Blankenberg Stefan , von Bardeleben R. Stephan , Zürn Christine , Bekeredjian Raffi , Ouarrak Taoufik , Sievert Horst , Nickenig Georg , Boekstegers Peter , Senges Jochen , Schillinger Wolfgang , Lubos Edith 
Published: July 2017

AbstractAimsWe sought to evaluate the impact of pulmonary hypertension on outcomes following MitraClip therapy.Methods and resultsThe 643 patients in the TRAnscatheter Mitral valve Interventions (TRAMI) registry were divided into three groups according to echocardiographically graded systolic pulmonary artery pressure (sPAP) (Group 1: patients with sPAP of ≤36 mmHg; Group 2: patients with sPAP of 37–50 mmHg; Group 3: patients with sPAP of >50 mmHg) and followed for 1 year. Recent cardiac decompensation, aortic valve disease and tricuspid valve insufficiency were observed more frequently in patients with higher sPAP. Furthermore, logEuroSCORE, Society of Thoracic Surgeons score and age were higher with rising sPAP values. No differences were observed in mitral regurgitation (MR) severity, co‐morbidities or clinical findings (New York Heart Association class, 6‐min walking distance). Reduction to MR of grade 1 or lower was achieved more often in patients with lower sPAP levels (P = 0.01). In Groups 2 and 3, sPAP was reduced significantly. Major adverse cardiac or cardiovascular events (MACCEs) occurring in hospital (death, myocardial infarction, stroke; <4% in each group), as well as 30‐day rates of MACCEs (6.1% in Group 1, 11.9% in Group 2, 12.4% in Group 3) and rehospitalization (18.9% in Group 1, 24.8% in Group 2, 24.8% in Group 3) did not differ significantly. At 1 year, differences in rates of mortality and MACCEs (20.3% in Group 1, 33.1% in Group 2, 34.7% in Group 3; P < 0.01) were significant. Both Groups 2 [hazard ratio (HR) 1.81, P = 0.0122] and 3 (HR 1.85, P = 0.0092) were independently predictive of death. Rehospitalization rates did not differ during follow‐up.ConclusionsDespite higher mortality in patients with elevated sPAP, these data suggest the safety, feasibility and benefit of MitraClip therapy even in advanced stages of disease. An early approach might prevent the progress of pulmonary hypertension and improve outcomes.
Novel bandlike signal abnormality suggestive of heterotopia in patient with a KCNQ1 frameshift mutation
Authors: Sabharwal Priyanka , Devinsky Orrin , M. Shepherd Timothy 
Published: July 2017

SummaryMalformations of cortical development are associated with epilepsy and cognitive dysfunction, and can occur in patients with SCN1A ion channel mutations. We report a novel and subtle bandlike subcortical heterotopia on integrated positron emission tomography–magnetic resonance imaging ( PET‐MRI) in a patient with treatment‐resistant epilepsy due to a de novo KCNQ1 frameshift mutation. Our case highlights the potential for other channel mutations to cause both epilepsy and cortical malformations. Further scrutiny of high contrast resolution MRI studies is warranted for patients with KCNQ1 and other epilepsy genes to further define their extended phenotype.
Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276)
Authors: Yang Youfeng , Vocke Cathy D. , Ricketts Christopher J. , Wei Darmood , Padilla‐Nash Hesed M. , Lang Martin , Sourbier Carole , Killian J. Keith , Boyle Shawna L. , Worrell Robert , Meltzer Paul S. , Ried Thomas , Merino Maria J. , Metwalli Adam R. , Linehan W. Marston 
Published: July 2017

AbstractChromophobe renal cell carcinoma (ChRCC) represents 5% of all RCC cases and frequently demonstrates multiple chromosomal losses and an indolent pattern of local growth, but can demonstrate aggressive features and resistance to treatment in a metastatic setting. Cell line models are an important tool for the investigation of tumor biology and therapeutic drug efficacy. Currently, there are few ChRCC‐derived cell lines and none is well characterized. This study characterizes a novel ChRCC‐derived cell line model, UOK276. A large ChRCC tumor with regions of sarcomatoid differentiation was used to establish a spontaneously immortal cell line, UOK276. UOK276 was evaluated for chromosomal, mutational, and metabolic aberrations. The UOK276 cell line is hyperdiploid with a modal number of 49 chromosomes per cell, and evidence of copy‐neutral loss of heterozygosity, as opposed to the classic pattern of ChRCC chromosomal losses. UOK276 demonstrated a TP53 missense mutation, expressed mutant TP53 protein, and responded to treatment with a small‐molecule therapeutic agent, NSC319726, designed to reactivate mutated TP53. Xenograft tumors grew in nude mice and provide an in vivo animal model for the investigation of potential therapeutic regimes. The xenograft pathology and genetic analysis suggested that UOK276 was derived from the sarcomatoid region of the original tumor. In summary, UOK276 represents a novel in vitro and in vivo cell line model for aggressive, sarcomatoid‐differentiated, TP53 mutant ChRCC. This preclinical model system could be used to investigate the novel biology of aggressive, sarcomatoid ChRCC and evaluate the new therapeutic regimes.
Petrography and geochemistry of sandstone–mudstone from Barakar Formation (early Permian), Raniganj Basin, India: Implications for provenance, weathering and marine depositional conditions during Lower Gondwana sedimentation
Authors: Bhattacharjee Joyeeta , Ghosh Kaushik Kiran , Bhattacharya Biplab 
Published: July 2017

Post‐glacial Permian coal‐bearing sedimentary successions are traditionally interpreted as fluvially deposited within the Gondwanaland continental set‐up throughout the globe. Recent attempts to reinterpret such successions in terms of marine flooding events, mainly based on sedimentological and ichnological attributes, raised doubt on the existing palaeogeographic model of the Late Palaeozoic Gondwanaland. Reassessing these sedimentary successions using other proxies, like petrographic and geochemical properties, may provide more reliable clues to improve the present understanding.In this paper, petrographic and geochemical analysis of sandstones, sandstone–mudstone heteroliths, and mudstones of the early Permian Barakar Formation of Lower Gondwana Supergroup, Raniganj coal Basin, India, is presented to understand the provenance, palaeoweathering pattern and palaeodepositional conditions. Petrographically, the sandstones are arkosic to sub‐arkosic in nature, with abundant unstable components and heavy minerals. Clay minerals in the matrix and the mudstones are dominated by kaolinite, illite‐smectite with authigenic glauconite, indicating a marine diagenetic realm. Mineralogical assemblage attests to sedimentation in craton interior passive margin conditions. Geochemically, the lithounits show large variations in major element and trace element (including rare earth element) concentrations. Chemical index of alteration and A–CN–K ternary plot indicate moderate to strong chemical weathering, leading to deposition of compositionally immature sediments close to their source without much recycling. Ratios of major elements (e.g., MgO, K2O, Fe2O3, Al2O3, and SiO2) signify a continental–marine transitional depositional environment developed in a stable passive margin setting under gradually warming up climatic conditions. Trace element ratios manifest an estuarine depositional setting during Barakar sedimentation, comparable with modern major river mouth estuaries.Thus, this paper provides unequivocal evidence of significant marine influence during sedimentation in the Lower Gondwana basins in India, particularly during the Permian time, and signifies the importance of re‐examining the so called “continental fluvial” coal‐bearing deposits as considerably marine‐influenced. The interpretations provide important clues in understanding and reconstructing the Permian Lower Gondwana palaeogeography in eastern peninsular India.