bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistics and simulation of growth of single bacterial cells: illustrations withB. subtilisandE. coli
Authors: van Heerden Johan H. , Kempe Hermannus , Doerr Anne , Maarleveld Timo , Nordholt Niclas , Bruggeman Frank J. 
Published: June 2017

ABSTRACTThe inherent stochasticity of molecular reactions prevents us from predicting the exact state of single-cells in a population. However, when a population grows at steady-state, the probability to observe a cell with particular combinations of properties is fixed. Here we validate and exploit existing theory on the statistics of single-cell growth in order to predict the probability of phenotypic characteristics such as cell-cycle times, volumes, accuracy of division and cell-age distributions, using real-time imaging data forEscherichia coliandBacillus subtilis. Our results show that single-cell growth-statistics can accurately be predicted from a few basic measurements. These equations relate different phenotypic characteristics, and can therefore be used in consistency tests of experimental single-cell growth data and prediction of single-cell statistics. We also exploit these statistical relations in the development of a fast stochastic-simulation algorithm of single-cell growth and protein expression. This algorithm greatly reduces computational burden, by recovering the statistics of growing cell-populations from the simulation of only one of its lineages. Our approach is validated by comparison of simulations and experimental data. This work illustrates a methodology for the prediction, analysis and tests of consistency of single-cell growth and protein expression data from a few basic statistical principles.
Identification of Rab18 as an Essential Host Factor for BKPyV Infection Using a Whole Genome RNA Interference Screen
Authors: Zhao Linbo , Imperiale Michael J. 
Published: June 2017

AbstractBK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection is ubiquitous in the human population, with over 80% of adults worldwide being seropositive for BKPyV. BKPyV infection is usually asymptomatic; however, BKPyV reactivation in immunosuppressed transplant patients causes two diseases, polyomavirus-associated nephropathy and hemorrhagic cystitis. To establish a successful infection in its host cells, BKPyV must travel in retrograde transport vesicles to reach the nuclei. To make this happen, BKPyV requires the cooperation of host cell proteins. To further identify host factors associated with BKPyV entry and intracellular trafficking, we performed a whole-genome siRNA screen on BKPyV infection of primary human renal proximal tubular epithelial cells. The results revealed the importance of the Ras-related protein Rab18 and syntaxin 18 for BKPyV infection. Our subsequent experiments implicated additional factors that interact with this pathway, and suggest a more detailed model of the intracellular trafficking process, indicating that BKPyV reaches the ER lumen through a retrograde transport pathway between the late endosome and the ER.
Tracking Subclonal Mutation Frequencies Throughout Lymphomagenesis Identifies Cancer Drivers in Mouse Models of Lymphoma
Authors: Webster Philip , Dawes Joanna C. , Dewchand Hamlata , Takacs Katalin , Iadarola Barbara , Bolt Bruce J. , Caceres Juan J. , Kaczor Jakub , Game Laurence , Adejumo Thomas , Elliott James , Naresh Kikkeri , Tan Ge , Dharmalingam Gopuraja , Paccanaro Alberto , Uren Anthony G. 
Published: June 2017

ABSTRACTDetermining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of retrovirus driven lymphomagenesis produced to date, sequencing 700,000 mutations from >500 malignancies collected at time points throughout tumor development. This enabled identification of positively selected events, and the first demonstration of negative selection of mutations that may be deleterious to tumor development indicating novel avenues for therapy. Customized sequencing and bioinformatics methodologies were developed to quantify subclonal mutations in both premalignant and malignant tissue, greatly expanding the statistical power for identifying driver mutations and yielding a high-resolution, genome wide map of the selective forces surrounding cancer gene loci. Screening two BCL2 transgenic models confirms known drivers of human B-cell non-Hodgkin lymphoma, and implicates novel candidates including modifiers of immunosurveillance such as co-stimulatory molecules and MHC loci. Correlating mutations with genotypic and phenotypic features also gives robust identification of known cancer genes independently of local variance in mutation density. An online resourcehttp://mulv.lms.mrc.ac.ukallows customized queries of the entire dataset.
An exploratory study on supply chain analytics applied to spare parts supply chain
Authors: Arya Vedpal , Sharma Pankaj , Singh Ashwani , De Silva P.T.M. 
Published: June 2017

Purpose
Big data analytics (BDA) has created a buzz around the world. It has been hailed as the new paradigm which has the potential to unlock value from otherwise non-productive aspects of the business. BDA has found application in the field of logistics and supply chain management (LSCM) too. Army has a large supply chain of various commodities which can benefit from BDA. The purpose of this paper is to explore the use of BDA in spare parts supply chain of the army.

Design/methodology/approach
The paper conducts a literature review to explain the application of supply chain analytics (SCA) to army spare parts supply chain. The paper presents a proposed architecture to apply SCA in the context of army supply chain.

Findings
The paper identifies various data points applicable to the field of LSCM in army. It also presents the impact areas of SCA on this supply chain. The architecture is presented which can serve as a roadmap for implementing SCA.

Originality/value
The paper is novel in its attempt to explain the supply chain of army and then apply SCA to it. The paper brings out a proposed architecture which can be further investigated to work on a roadmap to apply SCA to army supply chain.
Understanding the mobile payment technology acceptance based on valence theory
Authors: Ozturk Ahmet Bulent , Bilgihan Anil , Salehi-Esfahani Saba , Hua Nan 
Published: June 2017

PurposeThis study aims to examine factors affecting restaurant customers’ intention to use near field communication (NFC)-based mobile payment (MP) technology. More specifically, based on the valence theory, this paper examined the impacts of users’ negative valence (perceived risk and privacy concern) and positive valence (utilitarian value and convenience) perceptions toward their NFC-MP technology acceptance. Furthermore, the impacts of individual difference variables (smartphone affinity and compatibility) on users’ negative and positive valences and on their behavioral intentions were analyzed.Design/methodology/approachA self-administered online questionnaire was used to collect the data of the study from 412 restaurant customers. A confirmatory factor analysis (CFA) was used to validate the measurement model. To test the hypothesized model, structural equation modeling (SEM) was used.FindingsThe study findings demonstrated that privacy concern, utilitarian value and convenience significantly affected individuals’ NFC-MP technology acceptance. In addition, compatibility significantly influenced negative and positive valance constructs and smartphone affinity had a positive impact on positive valance constructs only.Practical implicationsThis study provides valuable practical implications for restaurant operators and hospitality technology vendors in the context of mobile payment systems.Originality/valueThis study successfully extended the valence framework by adding individual difference constructs to it.
Unveiling the role of information levels in consumers’ evaluative process on opaque-selling hotel websites
Authors: Chen Hsiangting Shatina , Jai Tun-Min (Catherine) , Yuan Jingxue 
Published: June 2017

Purpose
The purpose of this study is to investigate how the levels of perceived information influence consumers’ purchase evaluations and intentions when making hotel reservations on an opaque-selling travel website. Because of the uniqueness of the opaque-selling model, consumers must book a hotel room without knowing the hotel’s identity. Thus, consumers’ decision-making process is intricate and substantially influenced by the limited information provided by the websites.

Design/methodology/approach
This study used an experimental design approach that used promotional and preventative messages to manipulate the information levels. In total, 402 completed questionnaires were collected and analyzed by using quantitative research method.

Findings
The results indicated that perceived risks and perceived benefits lead toward different paths in regard to purchase intentions and information inquiries. To make a final booking decision, consumers have to go through a “debating” process, which involves assessing the overall value of the hotel deal claimed on the website.

Practical implications
To reduce consumers’ perceived risks and increase the likelihood of purchasing, opaque-selling websites should cautiously choose what information is displayed on their websites and also improve communications and interactions with the consumers.

Originality/value
This study contributes to the limited literature on information levels and its role in consumer’s evaluative process in the context of opaque-selling travel websites. In addition, this study has presented insights into opaque-buying behavior so that hotel manager may develop more appropriate pricing strategies for their target customer group.
Social inclusion and audience development at the Royal Opera House: a tourist perspective
Authors: Guachalla Adrian 
Published: June 2017

Purpose
The Royal Opera House, located at the epicentre of Covent Garden, stands as the UK’s leading provider of opera and ballet performances. Having been extensively redeveloped, its front facade is not visible from the area’s central market place and the perceived exclusivity and elitism commonly associated with its art forms also impose a challenge. This study aims to analyze the influence that the Opera House exerts on the tourist’s perception and experience of the world-renowned London’s “Theatreland”.

Design/methodology/approach
In all, three hundred and six semi-structured interviews with domestic, international, first-time and repeat tourists were conducted in six different locations throughout the area and inside the flagship building using a convenience sampling approach. These were then analyzed with the assistance of qualitative data analysis software (QSR N*Vivo) in two stages leading to an initial set of categorical topics that derived in a number of findings related to the factors that influence the tourist’s perception and experience of place.

Findings
The Opera House’s perceived urban concealment proved to have an impact on its influence on Covent Garden’s sense of place. But its social inclusion and audience development initiatives that foster a new generation of opera and ballet theatre-goers emerged as important findings as the House’s open door policy for daytime visitors along with live relays of current opera and ballet productions in other locations spark an interest in experiencing the building from the inside.

Research limitations/implications
This paper focuses exclusively on findings related to audience development and social inclusion initiatives currently used at the Royal Opera House and their impact on the tourist’s perception and experience of place. However, many other factors influence these processes and scope for further research is highlighted.

Practical implications
The Royal Opera House’s perceived urban concealment imposes a challenge to the task of developing new audiences for its current and future productions. Its learning and participation unit must endeavor to engage younger and international markets by focusing on the quality of the House’s performances, its heritage and added facilities of the venue such as exhibitions and shop.

Social implications
The Royal Opera House’s creed of “excellence, access and artistic development” is implemented by extending opportunities to younger target markets to engage with its cultural produce.

Originality/value
This paper addresses the gap in knowledge related to the development of the niche Opera House tourist segment of the cultural tourism market.
Comparing the gender gap in gross and base wages
Authors: Perez-Villadoniga Maria J. , Rodriguez-Alvarez Ana 
Published: June 2017

PurposeThe purpose of this paper is to examine the gender wage gap not only in gross wages, but also focussing on a specific salary component, the base wage, which is determined by collective bargaining for each occupational category.Design/methodology/approachThe authors estimate a wage frontier to analyze the difference between workers’ observed wages and their potential wage, given human capital endowments, as well as firm characteristics. Next, the authors examine the distance to the frontier as a function of workers’ gender, in order to test whether women fail to achieve potential wages to any great extent. To do so, the authors use data from the 2010 Spanish Structure of Earnings Survey.FindingsWhile men nearly achieve their potential base wage, females are systematically and significantly below the wage frontier (93 per cent on average). In other words, even when the authors limit the analysis to the base wage, the authors still find a significant wage differential between men and women. A detailed analysis of this result points to the existence of occupational segregation in the labour market. Within each occupational category, females tend to be concentrated in the lower ranking jobs, which entail lower wages. This result is consistent with the existence of a sticky floors phenomenon.Originality/valueThe authors contribute to the literature on gender discrimination that focusses on specific wage components. As far as the authors know, to date this is the first analysis to focus on a component that responds more to the characteristics of the job rather than to those of the worker.
Exploring nurtured company resilience through human capital and human resource development
Authors: Menéndez Blanco Juan Manuel , Montes-Botella José-Luis 
Published: June 2017

PurposeThe purpose of this paper is to evaluate the importance and contribution of human capital, combined with human resources and research and development (R&D) measures, to nurturing company resilience as new knowledge and human capital artifices to face challenges derived from globalization, competitiveness, and the knowledge-based economy.Design/methodology/approachBy means of structural equation modeling with latent variables, a new type of synthetic index is developed, with which the evolution and incidence of human capital structure, human resources development, and R&D in the company’s accumulated resiliency can be tested.FindingsThe results indicate a remarkable contribution of human capital to company resilience (standardized path coefficient 0.8365;p<0.0001 andR2=0.7486). Differences in company-nurtured resilience are related to categories such as productivity, products diversification, human capital structure, human resources management, innovation results, technology, and a productive environment.Research limitations/implicationsThe main limitation is that the applied literature on this topic is scarce in economics and focused on company survival.Practical implicationsManagement for resilience requires the development of the ability to balance efficiency in the short term with adaptability in the medium and long term. Recruitment and training and development policies should consider the role of emotions and motivation in creative thinking and innovation.Originality/valueMost research on the topic has been conducted within the ecological resilience approach. The adaptive resilience approach is considered an integrated framework based on the internal perspective of company capabilities, the theory of complex adaptive systems, and the Schultz-Nelson/Phelps view on human capital.
The mediating role of organizational embeddedness on the relationship between quality of work life and turnover
Authors: Dechawatanapaisal Decha 
Published: June 2017

PurposeThe purpose of this paper is to investigate the mediating effect of organizational embeddedness in the relationship between quality of work life (QWL) and turnover under a foundation of conservation of resources theory.Design/methodology/approachData were collected from 422 healthcare professionals through a questionnaire survey, and analyzed by means of a confirmatory factor analysis and structural equation modeling.FindingsThe results indicate that organizational embeddedness has a negative impact on employees’ intention to leave, and on actual turnover. For QWL perception, career opportunities, work life balance, and job characteristics are positive and significant predictors of organizational embeddedness. In addition, organizational embeddedness plays an intermediary role that mediates the relationship between the three components of QWL mentioned earlier and turnover intention, and also between the factor of career opportunities and actual turnover.Research limitations/implicationsThe current research took place within two healthcare organizations. Replicating the study in a variety of business sectors or professions with a larger sample of subjects would be useful for the generalizability of the findings.Practical implicationsOrganizations may improve their retention of employees by offering intrinsic resources that can be obtained from the social contexts of the individual through human resource management system, e.g., growth opportunities, a healthy and caring work life quality. Such motivational resources then develop a sense of obligation toward their places of employment, which influences their intention to stay or leave.Originality/valueThis study examines the mediating role of organizational embeddedness between employees’ perception of their work life quality and their desire and behavior to withdraw, which is an area of inquiry that has not been fully investigated in the literature.
Lean Six Sigma: yesterday, today and tomorrow
Authors: Antony Jiju , Snee Ronald , Hoerl Roger 
Published: June 2017

Purpose
The purpose of this paper is to share the experiences and perspectives of three practitioners from two continents on the subject of Lean Six Sigma (LSS) from both academic and industrial viewpoints. The authors of the paper have each been working on the topic of LSS over the past 15 years and have contributed over 150 journal and conference papers to the topics of lean and Six Sigma.

Design/methodology/approach
The approach is to synthesize the practical experiences and research conducted by three authorities on the topic of LSS. In addition, relevant secondary data have also been used in the sections where and when appropriate.

Findings
The authors initially present the history of LSS emphasizing the importance of integration of the two most effective process excellence methodologies over the past 30 years. The authors also report the current trends of LSS in organizations as well as the emerging future trends. They argue that LSS will continue to grow and evolve across the globe for several years.

Practical implications
The paper is intended to be equally useful to both academics and practitioners who are interested on the topic of LSS. From a pure practical standpoint, the paper provides an overview of the past, present and future trends of LSS as a powerful business strategy and problem-solving methodology for all industrial sectors, irrespective of their size and nature. The documentation of the history and recent developments in LSS should be useful to researchers in academia.

Originality/value
In authors’ best knowledge, there are no recent journal articles which cover all the three of these aspects; the past, the present and the future of LSS. This paper presents the above three aspects in a unique manner and addresses the gap between the current state and future directions of LSS.
Resiliency between Islamic and conventional banks in Bangladesh
Authors: Uddin Ajim , Chowdhury Mohammad Ashraful Ferdous , Islam Md. Nazrul 
Published: June 2017

Purpose
The purpose of this paper is to examine the resiliency between conventional banks (CBs) and Islamic banks (IBs) in Bangladesh at the financial crisis, pre-crisis and post-crisis period.

Design/methodology/approach
Data from 25 banks, 18 CBs and 7 IBs, operating in Bangladesh during the period 2005-2014 have been collected and divided into three stages: the pre-crisis period (2005-2006), the crisis period (2007-2008) and the post-crisis period (2009-2014). Dynamic generalized method of moments and quantile regression analysis have been used for this study.

Findings
This paper uses Z-score as an indicator of bank stability and found a significant difference in stability between IBs and CBs during the financial crisis. In addition, this paper also tries to identify the type of banks that performed better during pre-crisis, crisis and post-crisis periods but found no significant differences between IBs and CBs in this regards. For robustness, quantile regression found that the statistical significance level of credit risk, capital adequacy ratio and efficiency ratio of CBs and IBs differ at different percentile.

Originality/value
Most of the previous studies were conceptual or narrative and conducted on a global basis, not country-specific. To filling the country-level research gap, this study provides a meaningful insight about how these two types of banks performed in different periods.
Adult safeguarding and the Care Act (2014) – the impacts on partnerships and practice
Authors: Cooper Adi , Bruin Claire 
Published: June 2017

Purpose
The purpose of this paper is to look at the impacts on adult safeguarding partnerships and practice over 18 months following the implementation of the Care Act (2014) from the perspectives of an independent Chair of two Safeguarding Adults Boards (SABs) and a senior manager in adult social care in a local authority. They look at the areas of: wellbeing and safety, safeguarding activity and process, changing criteria and definitions, Making Safeguarding Personal, SABs, safeguarding adult reviews and advocacy.

Design/methodology/approach
The authors draw together information from published sources, experience and networks.

Findings
The paper argues that the impact on adult safeguarding and SABs has been greater than originally envisaged in a range of areas. This appears to be as a result of adult safeguarding having been made statutory, a new framework having been put in place, and added impetus given to a cultural change in adult safeguarding practice.

Originality/value
The authors have been engaged in delivering the adult safeguarding elements of the Care Act (2014) and so provide unique insight into the experience of making the changes required to meet the new statutory requirements and achieve the objective of protecting peoples’ rights to live in safety, free from abuse or neglect.