bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractures and Geological Analysis of the Water Breakthrough Patterns for the Production in X Carbonate Reservoir: A Case Study from Southeast Iraq
Authors: Chafeet H. A. , Al-Abadi A. M. , Homod R. Z. , Handhal A. M. 
Published: October 2024

Abstract

This study examines fracture analysis and characterization of the X carbonate reservoir within the AG oilfield in southeast Iraq, near the Iraq-Iran border. The reservoir is categorized into zones A, B, and C, each presenting unique challenges due to its complex fractured-porous nature, limited conventional log responses, a lack of special logs, and the structural difficulties caused by the Zagros orogeny. To evaluate fracture geometry and distribution and water breakthrough patterns and their influence on reservoir quality and production efficiency, the core samples, well logs, and thin sections from 10 wells were studied. The X carbonate reservoir analysis indicated that fractures typically range from 1–25 cm in length and 0.02–0.08 mm in width, predominantly high-angle to near-vertical fractures enhancing the reservoir's permeability. The reservoir properties indicate that member B has better physical properties than member A, with higher porosity and permeability. Fracture density varies significantly across the reservoir zones, ranging between 0.7 and 9.6 fractures/meter, averaging 4.7 fractures/meter and decreasing from A to C. In zones A and B, especially in the dolomite and limestone lithologies, these fractures contribute to improved permeability and higher well productivity. For example, wells AG-7A and AG-16 maintain steady production rates of 5000 and 3000 barrels per day. However, these fractures also lead to water breakthroughs, with 57.9% of wells encountering increasing in water cuts above 10%, therefore highlighting the difficulty in managing water production. Additionally, the time for water breakthrough and the location and perforation of every well were also considered in the process of water breakthrough analysis. Furthermore, the study identified three primary mechanisms for water breakthrough: gradual edge water invasion in member B of the southern area, fractures causing water breakthrough from member B to A, and bottom water invasion in the northern area. These findings highlight fractures' essential role in encouraging oil extraction and fasting water breakthroughs, which requires effective reservoir management to maximize hydrocarbon recovery while limiting water production.
Association between CCND1 rs9344 polymorphism and clinical prognosis of gastric cancer
Authors: Liu Xiaofang , Chen Lin , Xiaobin Chen , Shaobin Qiu , Zhenwen Liu , Lie Wang , Yuan Dang , Xu Qianhui 
Published: October 2024

Abstract

To investigate the difference between CCND1 rs9344 polymorphism and the clinical prognosis of patients with gastric adenocarcinoma after operation. The clinical data of patients with gastric adenocarcinoma confirmed by postoperative histopathology who underwent total gastrectomy or subtotal gastrectomy from July 2017 to December 2020 in the 90th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army were retrospectively analyzed. The polymorphism of CCND1 rs9344 in tissue samples was detected by PCR-RFLP. The relationship between the polymorphism of this locus and clinicopathological features and prognosis of gastric cancer was analyzed.A total of 529 patients with gastric cancer were enrolled. There were 88 (16.6%), 269 (50.9%) and 172 (32.5%) rs9344 polymorphisms detected in GG, GA and AA, respectively. The number of patients with each genome distribution was statistically significant in survival (P < 0.05). Cox multifactorial recurrence or metastasis, T4 stage, N3 stage, tumor diameter ≥5cm and AA genotype were independent risk factors for death. Female, tumor located in gastric antrum, low differentiation, lymph node metastasis stage N2-3, vascular nerve invasion, cancer nodule metastasis are independent risk factors for recurrence or metastasis. Homozygous mutation (AA) of CCND1 rs9344 polymorphism is an independent risk factor for postoperative death in gastric cancer patients.
Comparison of Diffusion-Weighted Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Detection of Peritoneal Carcinomatoses in Advanced Epithelial Ovarian Cancer
Authors: Cai Song-Qi , Huang Jian-Feng , Wu Min-Rong , Lu Jing-Jing , Ma Xiao-Liang , Ding Yu-Qin , Liu Guo-Bing , Qiang Jin-Wei , Liu Li-Heng , Zhou Jian-Jun , Zeng Meng-Su 
Published: October 2024

Abstract

Objectives: To compare the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) and 18F-fluorodeoxyglucose combined positron emission tomography combined with computed tomography(FDG-PET/CT) in detecting peritoneal carcinomatoses in advanced epithelial ovarian cancer (EOC).
Methods: This prospective study enrolled patients with stage III-IV EOC consecutively from October 2020 to February 2023. Participants underwent both DW-MRI and FDG-PET/CT. Three radiologists independently evaluated the radiological images using peritoneal cancer index (PCI) scoring systems. Clinical data, preoperative imaging assessments, and cytoreductive surgical outcomes were recorded. Univariate and multivariate analyses were performed to determine the critical regions for surgery associated with incomplete resection. The diagnostic performance of each imaging modality was calculated for each site. The interobserver agreement was assessed.
Results: Forty-eight patients were enrolled in this study. No statistically significant differences were found between the imaging modalities (p≥0.142) based on the PCI scoring evaluation system. Omental lesions extend to the hepatic flexure or splenic flexure (p=0.045, OR=20.891), and small bowel mesentery involvement (p=0.039, OR=21.814) were identified as surgically critical regions associated with incomplete resection. DW-MRI demonstrated significantly higher accuracy than FDG-PET/CT (p=0.049) in diagnosis at omental lesions extend to the hepatic flexure or splenic flexure and diaphragmatic peritoneum, with sensitivity and specificity of 0.773 and 0.792 for DW-MRI, and 0.619 and 0.696 for FDG-PET/CT, respectively. DW-MRI also showed higher interobservers agreement (k=0.654-0.782) compared to moderate agreement (k=0.515-0.745) in FDG-PET/CT.
Conclusion: DW-MRI and FDG-PET/CT were comparable in assessing the entire abdominopelvic tumor burden based on PCI scoring system. DW-MRI has an advantage in detecting omental lesions extending to the hepatic flexure or splenic flexure, which is predictive of incomplete resection.
Parental Bonding and Dyadic Adjustment. The Mediating Role of the Differentiation of Self
Authors: Lampis Jessica , Busonera Alessandra , Tommasi Marco 
Published: October 2024

Abstract

Emotional connections with significant caregivers greatly influence how individuals perceive themselves and others in intimate relationships. Grounded in adult attachment theory and the differentiation of self theory, this study examined factors that contribute to the quality of couple relationships. It investigated the association between parental attachment bonds and the quality of romantic attachments, as well as whether differentiation of self processes mediate these relationships. The study involved 480 participants in couple relationships, with an average age of 35.4 years, who completed assessments on parental attachment bonds (using the Parental Bonding Instrument), differentiation of self (using the Differentiation of Self Inventory Revised), and couple functioning (using the Dyadic Adjustment Scale). Structural Equation Modeling analyses revealed that the quality of parental attachment predicted distinct patterns of differentiation of self, which subsequently accounted for significant variability in dyadic adjustment levels. The implications of our findings are discussed.
Innovative Approach: MRI-Guided Fabrication of a Biomimetic Intervertebral Disc Scaffold
Authors: Ye Yuchen , Shao Chen , Wang Yi , Lin Fanguo , Su Peng , Niu Yanping , Yang Huiwen , Wang Zhicheng , Ma Tao , Ji Shuo , Chang Wenju , Wu Tao , Xi Jin , Wang Rui , Zhang Changchun , Sun Yongming 
Published: October 2024

Abstract

Study Design：A biomimetic intervertebral disc (IVD) scaffold was fabricated through the integration of magnetic resonance imaging (MRI) and 3D printing technology, and subsequently underwent in vitro experimentation.
Objective：This study aimed to create a new IVD scaffold using MRI grayscale image analysis and GE-DLP technology to mimic the natural structure of the IVD for improved biomechanical performance and cell compatibility, potentially providing a new treatment option for IVD regeneration.
Summary of Background Data: The IVD is a critical component of the spine, and its damage or degeneration can lead to severe back and neck pain. Current treatments provide symptomatic relief but do not address structural damage. Tissue engineering offers a promising alternative, with bio-scaffolds being a key element for IVD regeneration.
Methods: In this study, we constructed a 3D model of the IVD from MRI scans of a healthy volunteer and processed the grayscale images to distinguish between tissue types. Exposure times were adjusted based on grayscale values, and GE-DLP technology was applied to fabricate the biomimetic IVD scaffold in a single integrated process using a bicomponent polymer network (BCN) hydrogel laden with nucleus pulposus stem cells (NPMSCs). The microstructure and porosity of the scaffold were analyzed using scanning electron microscopy (SEM), and the elastic modulus across the radial distribution was tested via nanoindentation. The biomechanical performance was evaluated using finite element analysis (FEA). For biocompatibility assessment, cytoskeleton staining was utilized to observe cell morphology, and cell viability was evaluated using Calcein/PI staining.
Results: The biomimetic IVD scaffold exhibited gradient changes in elastic modulus and pore size, consistent with the ultrastructure and biomechanical characteristics of the natural IVD. FEA indicated that the scaffold's response in terms of displacement, strain, and stress closely resembled that of an actual IVD, particularly during simulations of left rotation and left lateral bending. SEM revealed a network structure of pores with varying sizes in different regions of the scaffold, which is crucial for cell adhesion and growth. The scaffold also demonstrated high biocompatibility, with cell survival rates maintained at a high level over a seven-day culture period.
Conclusion: In this research, we have successfully engineered a novel biomimetic IVD scaffold with excellent static structural integrity and biomechanical performance by integrating MRI image analysis with GE-DLP technology.
Level of Evidence: N/A
Antibiotic-Driven Pathogen Replacement Events in a Kidney Transplant Recipient with ADPKD: A Case Report
Authors: Yan Ziyan , Wang Yuchen , Zeng Wenli , Hui Jialiang , Yang Bin , Xu Jian , Miao Yun , Xia Renfei 
Published: October 2024

Abstract

Background
Retaining the native bilateral kidneys after transplantation is a common alternative treatment for patients with end-stage autosomal dominant polycystic kidney disease. However, this strategy poses the risks of potential complications from polycystic kidney infection. The efficiency of antibiotic therapy (ATBT) and the optimal time for native nephrectomy in managing these infections remain uncertain.
Case presentation:
We report a case of a kidney transplant recipient with retained bilateral polycystic kidneys who experienced recurrent cyst and bloodstream infections, accompanied by antibiotic-driven pathogen replacement. After multiple failed attempts at ATBT, the patient subsequently underwent unilateral polycystic kidney resection. Subsequently, a new infection episode occurred, leading to a preemptive native nephrectomy. Cystic tissue and fluid samples were collected from both shallow and deep layers of the polycystic kidneys, along with peripheral blood and urine samples. These samples were analyzed using microbial culture, metagenome sequencing, and digital polymerase chain reaction to identify infectious pathogens. Pathogen replacement occurred across different infection episodes, with the dominant bacterial species being Escherichia coli, Klebsiella aerogenes, and Enterococcus faecium, in succession.
Conclusions
This case highlights the replacement of dominant pathogens under antibiotic selection pressure in polycystic kidney infections, primarily involving gram-negative bacilli. When initial and subsequent ATBT fail, re-evaluation of the cyst infection definition is necessary, and preemptive native nephrectomy should be considered.
Investigation of Opioid Use Disorder and Its Relevant Risk Factors—A Cross-Sectional Survey in Hospitalized Medically Ill Patients
Authors: Khorshidian Faezeh , Kheirkhah Farzan , Moudi Sussan , Talari Davood Hosseini , Bijani Ali , Fathi Neda , Mohammadi Tahere , Mojarrad Minoo , Mirtabar Seyedeh Mahbobeh 
Published: October 2024

Abstract

People can become prone to addiction due to the interaction between nature and nurture. Opioids are one of the addictive substances that have reached an epidemic level worldwide. For the large proportion of patients, hospitalizations for medical reasons, is one of few interactions patients have with the healthcare system and potentially the only opportunity to receive opioid use screening. Due to the increase in global consumption, clinicians are concerned about the consequences of using opioids in medically ill patients. In this study, with a comprehensive approach, we evaluated the opioid use disorder and its relevant risk factors inhospitalized medical patients.This cross-sectional analytical study was conducted in medical wards of General Educational hospital in North of Iran,Sampling was done among 835 patients, hospitalized in different medical departments who were requested by their medical specialists for consultation by the psychiatric service, The information collected for this study was obtained based on the recorded data in the psychiatric consultation sheets, All psychiatric diagnoses in this project were based on DSM-5 diagnostic criteria.The rate of opioid use disorder among hospitalized medical patients was 17%. The highest rate of OUD was related to the age group of 25 to 40 years with 20.6%, men with 19.7%, divorced patients with 21.1%, and diploma to bachelor's education with 21.3%.In terms of comorbid medical disease, the highest rate was related to cardiovascular disease with 21.7%, followed by gastrointestinal disease with 14%. Most observed laboratory disturbance was the positive urine toxicology test, this test was the only variable that had a statistically significant relationship with OUD (P-value<0.001). In terms of comorbid psychiatry disorders, 9.9% of them had cluster B personality disorder, 7.8% had depressive disorder, 5% had anxiety disorder, and 2.1% had bipolar disorder.The findings of our research showed that opioid use disorder in medically ill patients, in men, the age group of 25 to 40 years, being divorced and having a diploma to bachelor's educational degree is higher. Cardiovascular diseases have the highest rate of association with OUD and the most laboratory disturbance in these patients is positive urine toxicology. We found that personality disorder cluster B and depressive disorder have a higher association with OUD than anxiety disorder and bipolar disorder.
Utilization of bio-based monomer derived from camelina oil and itaconic acid for the synthesis of film-forming latexes
Authors: Kolář Martin , Honzíček Jan , Podzimek Štěpán , Hájek Martin , Lukeš Vladimír , Klein Erik , Kocián David , Machotová Jana 
Published: October 2024

Abstract

The need for the production of synthetic polymers from renewable and sustainable resources also affects the area of emulsion polymerization. The bio-based monomer (BM) was synthesized from camelina oil (CO) and itaconic acid through transesterification and epoxidation of CO, followed by itaconation, resulting in a blend of methyl esters of CO-originated fatty acids functionalized with reactive methyl itaconate groups. Various amounts of BM were copolymerized with standard acrylic monomers (0−30 wt. % of BM in the monomer mixture) using the emulsion polymerization technique to obtain film-forming latexes. Infrared and Raman spectroscopies evidenced the successful incorporation of BM into the structure of latex polymers. The ultra-high molar mass nanogel fraction was detected by asymmetric flow-field flow fractionation coupled with a multiangle light scattering (AF4-MALS) for BM comprising copolymers; the higher the BM content, the more extensive the nanogel fraction. Crosslinking of latex polymers induced by BM testified to the reactivity of itaconated functions in emulsion polymerization and provided additional evidence of the copolymerization ability of the BM. The incorporation of BM also resulted in hardness and glass transition temperature enhancement (about 11% and 9°C, respectively, in the case of 30 wt. % of the BM content in contrast to 0 wt. % of the BM content in the copolymer). Coatings with excellent transparency and gloss were obtained from all latexes regardless of the BM content used. Slightly increased water repellency (about 7 ° increased water contact angle value) and significantly improved the water whitening resistance of the coatings (about 80% decreased water whitening after 1-day long water exposure) were found for coatings comprising 30 wt. % of BM in the copolymer, where the water whitening phenomenon was highly dependent on the BM content.
Assessing Genetic Relatedness of In Vitro Cassava Accessions Using Quantitative Morphological Traits and DarTseq Single Nucleotide Polymorphism (SNP) Markers
Authors: Byiringiro Moise Hubert , Uchendu Esther , Paliwal Rajneesh , Abberton Michael 
Published: October 2024

Abstract

Genetic diversity is crucial for breeding progress and biodiversity. Genetic relatedness was assessed using quantitative morphological traits (plant height, root length, number of roots, number of leaves, leaf length, leaf width, and number of leaf lobes) and SNP markers of 101 in vitro cassava (Manihot esculenta Crantz) accessions from the International Institute of Tropical Agriculture (IITA), Genetic Resources Centre, in 2023. Analysis of Variance (ANOVA) of morphological traits revealed significant differences (P < 0.01) of all traits across accessions and weeks. Root length and number of leaf lobes had significant differences (P < 0.01) across accessions and weeks. Cluster analysis identified four distinct clusters. Principal Component Analysis (PCA) revealed that the first three components explained 67.26% of the total variation among accessions. The leaf length (LL), Leaf width (LW), Number of roots (NR), Plant height (PH), and Root Length (RL) had the highest eigenvalues of -0.551, -0.531, -0.398, -0.383, and − 0.298 respectively in PC1. A strong positive correlation (r = 0.81***) was observed between leaf width and leaf length. Genome-wide SNP markers were generated using the DArTseq Genotype by Sequencing approach. Polygenic analysis using 19,467 SNPs identified four distinct genetic groups within cassava population. Phylogenetic and PCA analyses yielded consistent results. Molecularly, PCA revealed that the first three PCs explained 15%, 4.74%, and 3.7% of the genetic variation in the cassava population. SNP markers are effective for evaluating genetic diversity and identifying duplicates in the cassava collection. These results have important implications for cassava genebank management, quality control, conservation strategy, germplasm exchange, and future breeding efforts.
An Active Inference Strategy for Prompting Reliable Responses from
Large Language Models in Medical Practice
Authors: Shusterman Roman , Waters Allison , O’Neill Shannon , Luu Phan , Tucker Don 
Published: October 2024

Abstract

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and treatment. Most of the initial literature on LLMs in medicine has emphasized that LLMs are unsuitable for medical use because they are non-deterministic, may provide incorrect or harmful responses, and cannot be regulated to assure quality control. If these issues could be corrected, optimizing LLM technology could benefit patients and physicians by providing affordable, point-of-care medical knowledge. Our proposed framework refines LLM responses by restricting their primary knowledge base to domain-specific datasets containing validated medical information. Additionally, we introduce an actor-critic LLM prompting protocol based on active inference principles of human cognition, where a Therapist agent initially responds to patient queries, and a Supervisor agent evaluates and adjusts responses to ensure accuracy and reliability. We conducted a validation study where expert cognitive behaviour therapy for insomnia (CBT-I) therapists evaluated responses from the LLM in a blind format. Experienced human CBT-I therapists assessed responses to 100 patient queries, comparing LLM-generated responses with appropriate and inappropriate responses crafted by experienced CBT-I therapists. Results showed that LLM responses received high ratings from the CBT-I therapists, often exceeding those of therapist-generated appropriate responses. This structured approach aims to integrate advanced LLM technology into medical applications, meeting regulatory requirements for establishing the safe and effective use of special purpose validated LLMs in medicine.