bluuebunny/crossref_metadata_2025_split huggingface dataset:
The win/profit maximization debate: strategic adaptation as the answer?
Authors: Terrien Mickael , Scelles Nicolas , Morrow Stephen , Maltese Lionel , Durand Christophe 
Published: March 2017

Purpose
The purpose of this paper is twofold. First, to highlight the heterogeneity of the organizational aims within the professional football teams in Ligue 1. Second, to understand why some teams swing from a win orientation towards a soft budget constraint from year to year, and vice versa.

Design/methodology/approach
Financial data from annual reports for the period 2005/2015 was collected for the 35 Ligue 1 clubs. To define the degree of compliance with the intended strategy for those clubs, an efficiency analysis was conducted thanks to the data envelopment analysis method. This measure of performance was supplemented with the identification of productivity and demand shocks to identify whether clubs suffered from such shock or changed their strategy. It enables to precise the nature of the evolution in the utility function, with regards to the gap between expectation and actual performance.

Findings
The paper suggests that a team can switch from one orientation to another from year to year due to the uncertain nature of the sports industry. The club director’s utility function could also be maximized under inter temporal budget function in order to adjust the weight between win and profit according to the opportunities in the environment.

Originality/value
The paper sheds new light on the win/profit maximization. The theoretical model provides an assessment of the weight between win and profit in Ligue 1 and then identifies a new explanation for persistent losses in the sports industry.
More than pictures: who sets the agenda for sexuality education for people with learning disabilities?
Authors: Olsen Angela 
Published: March 2017

Purpose
The purpose of this paper is to provide a commentary on Cameron and Matthews’ paper “More than pictures: developing an accessible resource”.

Design/methodology/approach
It reflects on how much people with learning disabilities are involved in research and resource development and how the attitudes of caregivers impact on how people learn about sexuality.

Findings
Most published research is written by people who do not have learning disabilities but people with learning disabilities are taking part in research and they are making changes to the way things happen. Parents, educators and caregivers are often reluctant to discuss sexuality with people with learning disabilities and this affects how much people can understand about it.

Originality/value
This paper argues for greater involvement of people with learning disabilities in research processes.
Commentary on “The NICE guidelines and quality standards on learning disabilities and behaviour that challenges”
Authors: Busk Mary 
Published: March 2017

Purpose
The purpose of this paper is to provide a commentary, from a parent carer perspective, on Murphy’s overview of the NICE guidelines and quality standards on learning disabilities and behaviour that challenges.

Design/methodology/approach
The paper discusses the NICE approach, the content of these specific guidelines and quality standards and considers their practical relevance, with a particular focus on families of children and young people with learning disabilities and behaviour that challenges.

Findings
Gaps in research affect recommendations in some key areas including around transition and early intervention. Risk factors are not linked to clear recommendations for early identification and prevention. For families, additional work is needed to highlight where these guidelines fit with related national law and policies. Families also need to see how the guidelines can positively influence commissioners to improve life outcomes and avoid crises and deterioration in behaviour. Although NICE guidelines are often condition specific, many of our children and young people have co-existing conditions and so do not fit neatly into just one set of guidelines. That is why data collection is very important to understanding needs and to effective commissioning. There is a need to urgently identify and address the research gaps so that essential interventions are included in future NICE guidelines and standards.

Originality/value
A family carer perspective suggests ways in which implementation of the NICE guidelines can be supported and argues for the importance of the further research that will strengthen future versions of the guidelines.
Understanding disability in Nigeria: a commentary on “Country profile: intellectual and developmental disability in Nigeria”
Authors: McKenzie Judith , Ohajunwa Chioma Ogochukwu 
Published: March 2017

Purpose
The purpose of this paper is to respond to the country report about understanding disability in Nigeria by highlighting the important points that it raises and suggesting further areas for exploration.

Design/methodology/approach
The authors identify the main themes of the paper and situate these within an African context, recognizing the diversity of African countries while at the same time arguing that it is imperative for African countries to look to research from each other in addition to that emanating from the Global North.

Findings
The issues of terminology and lack of demographic detail in the Nigerian context are discussed and suggestions made as to how these might begin to be addressed. Features of the African context which are apparent in Nigeria, such as poverty, a very young population and the effects of forced migration, are amplified with reference to literature from other low-income countries. The significance of family care in this context is highlighted and identified as a focus for future research.

Originality/value
This paper speaks to the need to build an African body of knowledge around disability that is not ignorant of the literature from the Global North but which incorporates this knowledge in a critical way to understand better the African context.
A family’s battle to understand “challenging behaviour”
Authors: Jack David , Jack Jill 
Published: March 2017

Purpose
This is about the authors’ son James’ life. The purpose of this paper is to share a story of misfortune and a battle to find answers in which the greatest enemy was ignorance. Such experiences are not uncommon. It is the authors hope that sharing this will make some small contribution to bringing about change.

Design/methodology/approach
The authors discuss the experiences of care placements, and the battle to understand “challenging behaviour”.

Findings
Reflecting upon James’ experiences of the care system, it is clear that the system is fragmented and operates in silos that do not work together. Decision makers were all too often individuals not qualified to assess James’ needs and therefore implement appropriate solutions. The outcome was repeated failure which resulted in the view that he was a lost cause.

Originality/value
Such cruelty as James has experienced should be recognised and banished forever.
Rapid detection and quantification of Ebola Zaire virus by one‐step real‐time quantitative reverse transcription‐polymerase chain reaction
Authors: Ro Young‐Tae , Ticer Anysha , Carrion Ricardo , Patterson Jean L. 
Published: March 2017

ABSTRACTGiven that Ebola virus causes severe hemorrhagic fever in humans with mortality rates as high as 90%, rapid and accurate detection of this virus is essential both for controlling infection and preventing further transmission. Here, a one‐step qRT‐PCR assay for rapid and quantitative detection of an Ebola Zaire strain using GP, VP24 or VP40 genes as a target is introduced. Routine assay conditions for hydrolysis probe detection were established from the manufacturer's protocol used in the assays. The analytical specificity and sensitivity of each assay was evaluated using in vitro synthesized viral RNA transcripts. The assays were highly specific for the RNA transcripts, no cross‐reactivity being observed among them. The limits of detection of the assays ranged from 102 to 103 copies per reaction. The assays were also evaluated using viral RNAs extracted from cell culture‐propagated viruses (Ebola Zaire, Sudan and Reston strains), confirming that they are gene‐ and strain‐specific. The RT‐PCR assays detected viral RNAs in blood samples from virus‐infected animal, suggesting that they can be also a useful method for identifying Ebola virus in clinical samples.
The Capitalization of School Quality into Renter and Owner Housing
Authors: Beracha Eli , Hardin William G. 
Published: March 2017

AbstractResidential property amenities including school quality should be capitalized into both rent and property sale prices. Evidence of price and rent premiums for higher school quality is provided. The price premium for school quality for owners exceeds the premium for renters. The premiums paid by renters and owners vary with the likelihood the household directly uses school services, housing market conditions, whether the property is in an urban or suburban area and by the observed school quality in the years leading to the transaction. The larger price premium paid by owners is supported by enhanced liquidity and tempered price volatility for properties located in quality school districts.
Effect of AMP‐activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population
Authors: LI Qingchu , Li Cuilin , Li Haoyun , Zeng Liu , Kang Zhiqiang , Mao Yu , Tang Xinyue , Zheng Panpan , He Li , Luo Fang , Li Zhi 
Published: March 2017

AbstractBackgroundIt is well known that AMP‐activated protein kinase (AMPK) is a key factor affecting the development of type 2 diabetes mellitus (T2DM). The single nucleotide polymorphism (SNP) rs2746342 in the AMPK alpha 2 subunit gene (PRKAA2) has been found to be associated with susceptibility to T2DM in the Chinese Han population. The present study further investigates the association of PRKAA2 genotypes with susceptibility to T2DM and its complication, diabetic nephropathy.MethodsThe PRKAA2 genotypes of 406 T2DM patients and 214 controls from the Chinese Han population were determined with regard to SNPs rs10789038, rs2796498 and rs2746342. The association between these SNPs and susceptibility to T2DM and diabetic nephropathy was evaluated. The clinical characteristics differed significantly between T2DM patients and controls.ResultsAfter adjustment for age, sex and body mass index, there was an obvious relationship between T2DM and both rs10789038 (odds ratio [OR] 1.634; P = 0.015) and rs2796498 (OR 0.656; P = 0.030), but not rs2746342. There was haplotype association of PRKAA2 rs10789038–rs2796498–rs2746342 with T2DM susceptibility. In addition, rs2796498 was found to be related to the susceptibility to diabetic nephropathy.ConclusionsPolymorphisms in rs10789038 and rs2796498 are associated with the susceptibility to T2DM, and rs2796498 may be related to diabetic nephropathy.
Characteristics of Short‐stay Critical Care Admissions From Emergency Departments in Maryland
Authors: Chidi Obiora O. , Perman Sarah M. , Ginde Adit A. 
Published: March 2017

AbstractObjectivesCritical care is an expensive and limited resource, and short‐stay critical care admissions may be treated in alternate, less costly settings. This study objective was to determine the proportion of critical care admissions with a short critical care length of stay (LOS) and identify the clinical characteristics and diagnoses associated with high and low rates of short‐stay critical care admissions.MethodsThis study was a secondary analysis of the 2011 Maryland State Inpatient Database. The study included adult emergency department (ED) visits admitted to a critical care unit. We compared clinical data and discharge diagnoses for short‐ (≤1 day) versus longer‐ (≥2 days) stay critical care admissions.ResultsA total of 30,212 critical care admissions were eligible, of which 11,494 (38.0%) were short stay. There were significant differences in age, insurance, and comorbidities between the short‐stay and the longer‐stay critical care admissions. Of short‐stay critical care admissions, 3,404 (29.6%) also had a 1‐day overall hospital LOS. The diagnoses with the highest proportion of short‐stay critical care admissions were nonspecific chest pain (87.9%), syncope (70.6%), and transient cerebral ischemia (67.6%) and the lowest proportion were respiratory failure (17.9%), sepsis (19.4%), and aspiration pneumonitis (19.8%).ConclusionsOver one‐third of critical care admissions were short stay. Alternate strategies to manage these patients, including ED‐based critical care units or other venues of inpatient care, may be more cost‐efficient for selected patients.
Alcohol‐Related Blackouts, Negative Alcohol‐Related Consequences, and Motivations for Drinking Reported by Newly Matriculating Transgender College Students
Authors: Tupler Larry A. , Zapp Daniel , DeJong William , Ali Maryam , O'Rourke Sarah , Looney John , Swartzwelder H. Scott 
Published: March 2017

BackgroundMany transgender college students struggle with identity formation and other emotional, social, and developmental challenges associated with emerging adulthood. A potential maladaptive coping strategy employed by such students is heavy drinking. Prior literature has suggested greater consumption and negative alcohol‐related consequences (ARCs) in transgender students compared with their cisgender peers, but little is known about their differing experiences with alcohol‐related blackouts (ARBs). We examined the level of alcohol consumption, the frequency of ARBs and other ARCs, and motivations for drinking reported by the largest sample of transgender college students to date.MethodsA Web survey from an alcohol‐prevention program, AlcoholEdu for College™, assessed student demographics and drinking‐related behaviors, experiences, and motivations of newly matriculating first‐year college students. A self‐reported drinking calendar was used to examine each of the following measures over the previous 14 days: number of drinking days, total number of drinks, and maximum number of drinks on any single day. A 7‐point Likert scale was used to measure ARCs, ARBs, and drinking motivations. Transgender students of both sexes were compared with their cisgender peers.ResultsA total of 989 of 422,906 students (0.2%) identified as transgender. Over a 14‐day period, transgender compared with cisgender students were more likely to consume alcohol over more days, more total drinks, and a greater number of maximum drinks on a single day. Transgender students (36%) were more likely to report an ARB than cisgender students (25%) as well as more negative academic, confrontation‐related, social, and sexual ARCs. Transgender respondents more often cited stress reduction, social anxiety, self‐esteem issues, and the inherent properties of alcohol as motivations for drinking. For nearly all measures, higher values were yielded by male‐to‐female than female‐to‐male transgender students.ConclusionsTransgender compared with cisgender first‐year students engage in higher‐risk drinking patterns and experience more ARBs and other negative ARCs. Broad institutional efforts are required to address the unique circumstances of transgender men and women and to reduce negative ARCs in college students, regardless of their sex or gender identity.
Trade union participation in CSR deliberation: an evaluation
Authors: Harvey Geraint , Hodder Andy , Brammer Stephen 
Published: March 2017

AbstractWhereas there has been considerable interest in the concept of political corporate social responsibility (CSR), trade unions have been largely omitted from such scholarly discussion. This article explores the potential of trade unions as the other in political CSR and the contribution of trade unions to deliberative democracy with the firm. We discuss the importance both of the legitimacy and the efficacy of the other in political CSR. We proceed to assess trade unions as legitimate and effective deliberative partners with the firm towards CSR, evaluating the contribution of trade unions to deliberative democracy and also the potential outcomes for trade unions in adopting this role.
Flexible institutional arrangements and labour productivity: the case of transit industry in the United States
Authors: Smirnova Olga V. 
Published: March 2017

AbstractUsing the US National Transit Database 1994–2006, the manuscript empirically tests the influence of several institutional arrangements on labour productivity. The main finding of the paper is that not all flexible institutional arrangements may translate into labour productivity gains in the mass transit. While partial contracting may increase labour productivity in the US transit sector during the study period, the special governance actually decreases labour productivity. The potential implications for improvements in labour productivity are discussed.
The V2 receptor antagonist tolvaptan raises cytosolic calcium and prevents AQP2 trafficking and function: an in vitro and in vivo assessment
Authors: Tamma Grazia , Di Mise Annarita , Ranieri Marianna , Geller Ari , Tamma Roberto , Zallone Alberta , Valenti Giovanna 
Published: March 2017

AbstractTolvaptan, a selective vasopressin V2 receptor antagonist, is a new generation diuretic. Its clinical efficacy is in principle due to impaired vasopressin‐regulated water reabsorption via aquaporin‐2 (AQP2). Nevertheless, no direct in vitro evidence that tolvaptan prevents AQP2‐mediated water transport, nor that this pathway is targeted in vivo in patients with syndrome of inappropriate antidiuresis (SIAD) has been provided. The effects of tolvaptan on the vasopressin–cAMP/PKA signalling cascade were investigated in MDCK cells expressing endogenous V2R and in mouse kidney. In MDCK, tolvaptan prevented dDAVP‐induced increase in ser256‐AQP2 and osmotic water permeability. A similar effect on ser256‐AQP2 was found in V1aR −/− mice, thus confirming the V2R selectively. Of note, calcium calibration in MDCK showed that tolvaptan per se caused calcium mobilization from the endoplasmic reticulum resulting in a significant increase in basal intracellular calcium. This effect was only observed in cells expressing the V2R, indicating that it requires the tolvaptan–V2R interaction. Consistent with this finding, tolvaptan partially reduced the increase in ser256‐AQP2 and the water permeability in response to forskolin, a direct activator of adenylyl cyclase (AC), suggesting that the increase in intracellular calcium is associated with an inhibition of the calcium‐inhibitable AC type VI. Furthermore, tolvaptan treatment reduced AQP2 excretion in two SIAD patients and normalized plasma sodium concentration. These data represent the first detailed demonstration of the central role of AQP2 blockade in the aquaretic effect of tolvaptan and underscore a novel effect in raising intracellular calcium that can be of significant clinical relevance.
Efficacy of ixekizumab compared to etanercept and placebo in patients with moderate‐to‐severe plaque psoriasis and non‐pustular palmoplantar involvement: results from three phase 3 trials (UNCOVER‐1, UNCOVER‐2 and UNCOVER‐3)
Authors: Menter A. , Warren R.B. , Langley R.G. , Merola J.F. , Kerr L.N. , Dennehy E.B. , Shrom D. , Amato D. , Okubo Y. , Reich K. 
Published: March 2017

AbstractBackgroundPalmoplantar psoriasis has significant physical and emotional impact on patients and can be difficult to treat.ObjectiveTo evaluate the efficacy of ixekizumab in the treatment of patients with moderate‐to‐severe plaque psoriasis and moderate‐to‐severe non‐pustular palmoplantar involvement.MethodsIn three phase 3, double‐blind, placebo‐controlled trials, patients with moderate‐to‐severe non‐pustular plaque psoriasis [UNCOVER‐1 (N = 1296), UNCOVER‐2 (N = 1224), UNCOVER‐3 (N = 1346)] were randomized to subcutaneous 80 mg ixekizumab every 2 or 4 weeks (Q2W, Q4W), after a 160‐mg starting dose, or placebo through week 12. Additional UNCOVER‐2 and UNCOVER‐3 cohorts were randomized to 50 mg etanercept biweekly. Patients entering the open‐label long‐term extension (UNCOVER‐3) received ixekizumab Q4W weeks 12–60. Moderate‐to‐severe palmoplantar involvement was defined as Palmoplantar Psoriasis Area and Severity Index (PPASI) ≥8.ResultsTwenty‐eight percent of UNCOVER‐1, UNCOVER‐2 and UNCOVER‐3 patients had baseline palmoplantar involvement (PPASI ≥0, n = 1092) and 9.1% (n = 350) had moderate‐to‐severe involvement, with mean baseline PPASI ~20, PASI ~24, and most (>60%) had static Physician's Global Assessment ≥4. Higher percentages of patients treated with ixekizumab vs. placebo or etanercept achieved PPASI 50 (approximately 80% vs. 32.9%, 67.8%; ixekizumab, placebo, etanercept, respectively) and PPASI 75 (approximately 70% vs. 18.8%, 44.1%; ixekizumab, placebo, etanercept, respectively) at week 12 (all P < 0.05). PPASI 100 was achieved by higher percentages of ixekizumab‐treated patients vs. placebo (approximately 50% vs. 8.2%, P < 0.001) and ixekizumab Q2W‐treated patients vs. etanercept (51.8% vs. 32.2%, P < 0.05). Outcomes were maintained or improved in patients continuing on ixekizumab Q4W through week 60. Differences between ixekizumab and placebo or etanercept were statistically significant as early as week 1.ConclusionIn a subpopulation analysis of patients from phase 3 trials with moderate‐to‐severe non‐pustular palmoplantar involvement and moderate‐to‐severe plaque psoriasis, ixekizumab treatment resulted in greater and more rapid improvements than placebo and etanercept at week 12; improvements were sustained with continued treatment.
Biogenesis, assembly and trafficking of acetylcholinesterase
Authors: Rotundo Richard L. 
Published: March 2017

AbstractAcetylcholinesterase (AChE) is expressed as several homomeric and heterooligomeric forms in a wide variety of tissues such as neurons in the central and peripheral nervous systems and their targets including skeletal muscle, endocrine and exocrine glands. In addition, glycolipid‐anchored forms are expressed in erythropoietic and lymphopoietic cells. While transcriptional and post‐transcriptional regulation is important for determining which AChE oligomeric forms are expressed in a given tissue, translational and post‐translational regulatory mechanisms at the level of protein folding, assembly and sorting play equally important roles in assuring that the AChE molecules reach their intended sites on the cell surface in the appropriate numbers. This brief review will focus on the latter events in the cell with the goal of providing novel therapeutic interventional strategies for the treatment of organophosphate and carbamate pesticide and nerve agent exposure.This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
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Dietary Protein and Lipid Requirements for Juvenile Largemouth Bass, Micropterus salmoides
Authors: Huang Di , Wu Yubo , Lin Yayun , Chen Jianming , Karrow Niel , Ren Xing , Wang Yan 
Published: March 2017

AbstractA feeding trial was conducted to evaluate dietary protein and lipid requirements for juvenile largemouth bass, Micropterus salmoides. A 4 × 2‐factorial layout included four protein (420, 450, 480, and 510 g/kg) and two lipid (80 and 120 g/kg) levels. Fish (initial weight 8.7 g) were fed the test diets for 8 wk. Weight gain, feed intake, feed conversion ratio, hepatosomatic index, and body composition were dependent on dietary protein level. Nitrogen retention efficiency was independent of dietary protein level, lipid level, and their interaction. Weight gain was higher in fish fed the diet containing 480–510 g/kg crude protein than in fish fed the diet containing 420–450 g/kg crude protein at two dietary lipid levels. The feed intake and weight gain were higher in fish fed the diet containing 484 g/kg crude protein and 115 g/kg crude lipid than in fish fed the diet containing 478 g/kg crude protein and 77 g/kg crude lipid. This study indicated that the suitable dietary protein and lipid levels for largemouth bass are 480–510 g/kg and 120 g/kg, respectively.