bluuebunny/crossref_metadata_2025_split huggingface dataset:
SYSTEM‐AWARE CYBER SECURITY: A SYSTEMS ENGINEERING APPROACH FOR ENHANCING CYBER SECURITY
Authors: Horowitz Barry M. , Lucero D. Scott 
Published: October 2017

ABSTRACTThis article highlights the importance of concurrently addressing process, people, and technology factors when conducting research related to new systems engineering concepts. In particular, an ongoing US Department of Defense‐sponsored, University of Virginia‐led cyber security research project is used as an example of how concurrent research activities provide value earlier in the technology design phase than otherwise would have occurred. The example project focuses on adding a new layer of protection for computer‐controlled physical systems. Through concurrent efforts, the research team developed a better a protection approach, resulting in better prospects for transition into use.
ON DEFINING AGILE SYSTEMS ENGINEERING
Authors: Dove Rick 
Published: October 2017

ABSTRACTThe author was asked to define Agile Systems Engineering, and found it necessary, for context, to first develop some thoughts on what engineering and systems engineering might be. This led to thoughts on differentiating engineering from crafting and arting. Engineering, crafting, and arting are activities carried out by artifact creators with different purposes, but at the core, all are constrained and enabled by the laws of coherence. This article does not suggest what those laws might be; but does conclude that the definition of agile systems engineering is rooted in what it does, not how it does it.
An efficient Bayesian approach to multiple structural change in multivariate time series
Authors: Maheu John M. , Song Yong 
Published: October 2017

SummaryThis paper provides a feasible approach to estimation and forecasting of multiple structural breaks for vector autoregressions and other multivariate models. Owing to conjugate prior assumptions we obtain a very efficient sampler for the regime allocation variable. A new hierarchical prior is introduced to allow for learning over different structural breaks. The model is extended to independent breaks in regression coefficients and the volatility parameters. Two empirical applications show the improvements the model has over benchmarks. In a macro application with seven variables we empirically demonstrate the benefits from moving from a multivariate structural break model to a set of univariate structural break models to account for heterogeneous break patterns across data series.
An engineered tendon/ligament bioscaffold derived from decellularized and demineralized cortical bone matrix
Authors: Yang Jie‐Liang , Yao Xuan , Qing Quan , Zhang Yi , Jiang Yan‐Lin , Ning Liang‐Ju , Luo Jing‐Cong , Qin Ting‐Wu 
Published: October 2017

AbstractDemineralized bone matrix (DBM), as an extracellular matrix (ECM), has had limited use as a medical replacement although studies have reported a possibility for its use in tendon or ligament tissue engineering. To be an acid‐extracted organic matrix, DBM contains much of bone protein, with a small amount of inorganic solids and some cell debris. However, cell debris is a critical factor that triggers inflammatory reaction in clinical reconstructions using ECM. In this study, we used a protocol incorporating the use of detergent with nuclease treatment to prepare decellularized DBM (DCDBM). DNA quantification analysis and histological observation confirmed that cells were completely removed from DBM. The inherent ultrastructure of DBM was well preserved after decellularization as observed through scanning electron microscopy. Additionally, calcium and phosphorus were absent and the specific functional groups of collagen remained after decellularization. Moreover, 79.71% of the tensile strength of DBM was retained and the viscoelastic properties were similar to the ligament. Furthermore, DCDBM promoted the adhesion and proliferation of NIH‐3T3 fibroblasts in vitro and triggered less inflammation response at 12 weeks subcutaneous implantation in a rat model. These results demonstrate that the DCDBM has the potential to be used for tendon and ligament replacement. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 468–478, 2018.
One pot synthesis of new poly(vinyl alcohol) blended natural polymer based magnetic hydrogel beads: Controlled natural anticancer alkaloid delivery system
Authors: Kesavan Mookkandi Palsamy , Ayyanaar Srinivasan , Lenin Nayagam , Sankarganesh Murugesan , Dhaveethu Raja Jeyaraj , Rajesh Jegathalaprathaban 
Published: October 2017

AbstractFacile one‐pot synthesis has been demonstrated for new biocompatible and dual responsive magnetic iron oxide nanoparticles cross‐linked poly(vinyl alcohol) (PVA) blended natural polymer chitosan (CS) based hydrogel beads (mCS‐PVA) as a controlled natural anticancer alkaloid Luotonin A (LuA) delivery system. The prepared magnetic hydrogel beads were characterized using powder X‐ray diffraction measurement, Fourier transform‐infrared spectroscopy, scanning electron microscopy, energy dispersive X‐ray spectroscopy, and vibrating sample magnetometer. The magnetic hydrogel beads are exhibited significant water retention and follow the second order kinetic model in swelling study. The swelling ratio of the magnetic gel beads increased by the addition of PVA and showed a maximum swelling ratio of 40.83 ± 1.01 g/g and follows non‐Fickian water transport mechanism. Stimuli responsive mCS and mCS‐PVA hydrogel beads functionalized with LuA is demonstrated for controlled release at physiological pH and under magnetic field. The magnetic hydrogel beads show highest LuA releasing efficacy at acidic medium (pH = 5.0) with maximum efficiency of 73.33 ± 1.44%. This efficacy may also be tuned by altering the external magnetic field as well as the weight percentage (wt %) of polyethylene glycol. It is clearly that the newly produced magnetic hydrogel beads can be served as an effective intestinal LuA delivery system. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 543–551, 2018.
In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy
Authors: Jin Shujing , Qi Xun , Wang Tongmin , Ren Ling , Yang Ke , Zhong Hongshan 
Published: October 2017

AbstractEndothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in‐stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605‐Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605‐Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605‐Cu. Furthermore, L605‐Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605‐Cu had better blood compatibility. These results above have demonstrated that the L605‐Cu alloy is promising to be a new stent material with function of accelerating endothelialization. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561–569, 2018.
Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow‐derived human mesenchymal stem cells for bone tissue regeneration
Authors: Reinwald Yvonne , El Haj Alicia J. 
Published: October 2017

AbstractTopographical and mechanical cues are vital for cell fate, tissue development in vivo, and to mimic the native cell growth environment in vitro. To date, the combinatory effect of mechanical and topographical cues as not been thoroughly investigated. This study investigates the effect of PCL nanofiber alignment and hydrostatic pressure on stem cell differentiation for bone tissue regeneration. Bone marrow‐derived human mesenchymal stem cells were seeded onto standard tissue culture plastic and electrospun random and aligned nanofibers. These substrates were either cultured statically or subjected to intermittent hydrostatic pressure at 270 kPa, 1 Hz for 60 min daily over 21 days in osteogenic medium. Data revealed higher cell metabolic activities for all mechanically stimulated cell culture formats compared with non‐stimulated controls; and random fibers compared with aligned fibers. Fiber orientation influenced cell morphology and patterns of calcium deposition. Significant up‐regulation of Collagen‐I, ALP, and Runx‐2 were observed for random and aligned fibers following mechanical stimulation; highest levels of osteogenic markers were expressed when hydrostatic pressure was applied to random fibers. These results indicate that fiber alignment and hydrostatic pressure direct stem cell fate and are important stimulus for tissue regeneration. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: A: 629–640, 2018.
Sonographic diagnosis and prognosis of fetal arachnoid cysts
Authors: Yin Linliang , Yang Zhong , Pan Qi , Zhang Jun , Li Xiaobing , Wang Feng , Ye Yanlin , Deng Xuedong , Hu Chunhong 
Published: October 2017

AbstractPurposeTo explore the clinical significance of sonographic (US) diagnosis of fetal arachnoid cysts and to evaluate their prognosis.MethodsSixty fetuses deemed to have arachnoid cysts by prenatal US were included in this study. Data from serial US, prenatal and/or postnatal MRI, or post‐mortem examinations were retrospectively analyzed. For live births, the developmental quotient scores were determined using the Gesell Developmental Scale.ResultsThirty fetuses were diagnosed during the second trimester and another 30 fetuses were diagnosed in the third trimester. Fifty‐one lesions were located in the supratentorial compartment, and 9 were located in the posterior fossa. Twenty‐four lesions were isolated, and the remaining lesions were associated with intracranial and/or extra central nervous system malformations. The evolution of the cysts included progression, stability, or spontaneous resolution. The outcomes included induced abortion, intrauterine death, live birth with either normal neurodevelopment or mental retardation, and infant mortality. Two cases were lost to follow‐up. The accuracy of prenatal US diagnosis was 86.2% (50/58).ConclusionPrenatal US is the modality of choice for the diagnosis of fetal arachnoid cysts. Serial US examinations are critical to monitor the lesions. Moreover, prenatal MRI is a valuable complementary tool. For live births, the prognosis appears to be good.
Contrast‐enhanced ultrasound examination of the gallbladder and bile ducts: A pictorial essay
Authors: Cokkinos Demosthenes D. , Antypa Eleni G. , Tsolaki Sofia , Skylakaki Maria , Skoura Alkmini , Mellou Vassiliki , Kalogeropoulos Ioannis 
Published: October 2017

AbstractThe gallbladder and bile ducts are usually assessed initially with conventional gray‐scale ultrasound (US). Contrast enhanced US (CEUS) is used when a diagnosis cannot be reached with conventional US. CEUS is easy to learn and perform. US contrast agents can be safely administered in patients with renal function impairment. In this pictorial essay the physics, examination technique and indications of CEUS for examining the gallbladder and bile ducts are reviewed. Gallbladder indications include elucidating normal variants, differentiating sludge from neoplastic lesions, benign and malignant pathology, infection, wall rupture and hemobilia. In the biliary tree CEUS is used for studying benign and malignant tumors, including metastases and cholangiocarcinoma, as well as intrabiliary injection.
Molecular design of Stat3‐derived peptide selectivity between BET proteins Brd2 and Brd4 in ovarian cancer
Authors: Zhu Lixia , Ding Xi 
Published: October 2017

AbstractStat3 signaling has been recognized as a potential therapeutic target of human ovarian cancer. The signaling is transducted through the peptide‐medicated interaction of Stat3 with BET family members Brd2 and Brd4 –– 2 highly homologous proteins involved in differential downstream pathways. Here, we reported a successful design of peptide selectivity between the Brd2 and Brd4. The design resulted in 3 linear peptides SMSLQCXYLGVA, QSKVLTXSYWGA, and RQCNLGXLYMNY with high or moderate selectivity for Brd2 over Brd4 (S = 3.3‐fold, 6.8‐fold, and 4.2‐fold, respectively) as compared with the native Stat3 peptide 281HNLLRIXQFLQS292 (S = 2.5‐fold). Structural analysis revealed that peptide N‐terminus and hydrogen bonds play important roles in the peptide interaction stability and specificity with Brd2 and Brd4. This study would help to establish an integrated in silico‐in vitro method for rational molecular design of peptide ligand selectivity between homologous protein receptors.
The role of self‐regulation in the relationship between abusive supervision and job tension
Authors: McAllister Charn P. , Mackey Jeremy D. , Perrewé Pamela L. 
Published: October 2017

SummaryTrait and state self‐regulation both have critical influences on workplace behavior, but their influences are thought to operate quite differently. We draw from social exchange and ego depletion theories to investigate the relationship between trait and state self‐regulation, as well as how they differentially affect the relationship between subordinates' perceptions of abusive supervision and job tension. Specifically, we examine (a) how the interaction between abusive supervision and trait self‐regulation affects job tension and (b) how state self‐regulation mediates the relationship between abusive supervision and job tension. Using 3 studies that include an experiment (n = 81) and 2 field studies with cross‐sectional (n = 157) and time‐separated (n = 109) data, we demonstrate that the interaction between abusive supervision and trait self‐regulation increases experienced job tension for subordinates who report higher levels of abusive supervision and trait self‐regulation than others. Also, we provide evidence that abusive supervision is indirectly associated with job tension through state self‐regulation. This study's findings have important implications for abusive supervision and self‐regulation research, as well as social exchange and ego depletion theories, because we extend our understanding of how trait and state self‐regulation affect cognitive responses associated with abusive supervision.
Etiology of developmental spinal stenosis: A genome‐wide association study
Authors: Cheung Jason P. Y. , Kao Patrick Y. P. , Sham Pak , Cheah Kathryn S. E. , Chan Danny , Cheung Kenneth M. C. , Samartzis Dino 
Published: October 2017

ABSTRACTOur study aimed to identify possible single nucleotide polymorphisms (SNPs) via a genome‐wide association study (GWAS) approach and a candidate gene platform that were associated with lumbar developmental spinal stenosis (DSS). Southern Chinese population‐based study volunteers were assessed (age range: 18–55 years). DSS was defined as the anteroposterior bony spinal canal diameter on T1‐weighted axial MRI of L1 to S1. Genotyping was performed using the Illumina HumanOmniZhongHua‐8 BeadChip. Using the canal diameter as the quantitative trait, genomic statistical analyses was performed. A total of 469 subjects were recruited. The mean axial AP measurements noted were: L1: 21.8 mm, L2: 21.9 mm, L3: 22.4 mm, L4: 20.2 mm, L5: 19.6 mm, and S1: 17.3 mm. Q–Q plots of genome‐wide associations found significant differences in L4 and L5 measurements. More significant SNPs were found on chromosomes 8, 11, and 18. Low‐density lipoprotein receptor‐related protein 5 on chromosome 11 was found to be an important functional gene in canal bony development via candidate gene approach. We found two clusters in the findings with one including the upper levels (L1–L4) and the other the lower levels (L5 and S1). This is the first GWAS addressing DSS. The presence of multiple SNPs suggests a multi‐factorial origin of DSS. Further analyses noted region‐specific genetic predisposition, delineating distinct upper to lower lumbar regions of DSS. With better understanding of the DSS phenotype and genetic markers, the at‐risk population can be identified early, preventative measures can be initiated, lifestyle/activity modification can be implemented, and more novel and precision‐based therapeutics can be developed. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1262–1268, 2018.
Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction
Authors: Erhart‐Hledik Jennifer C. , Chu Constance R. , Asay Jessica L. , Andriacchi Thomas P. 
Published: October 2017

ABSTRACTThe purpose of this study was to longitudinally investigate changes in knee joint kinematics and kinetics from 2 to 8 years post‐ACLR. Seventeen subjects with primary unilateral transtibial ACLR performed bilateral gait analysis approximately 2 years and 8 years post‐ACLR. Seventeen matched healthy control subjects were also analyzed. Kinematic and kinetic comparisons between the ACLR and contralateral limbs over time were completed using a 2 × 2 (time, limb) repeated‐measures ANOVA. Unpaired Student's t‐tests were used to compare the ACLR and contralateral kinematics and kinetics to the control group. The ACLR and contralateral limbs had similar gait changes over time. Kinetic changes over time included a reduction in first (p = 0.048) and second (p < 0.001) peak extension moments, internal rotation moment (p < 0.001), adduction moment (first peak: p = 0.002, second peak: p = 0.009, impulse: p = 0.004) and an increase in peak knee flexion moment (p = 0.002). Kinematic changes over time included increases in peak knee flexion angle in the first half of stance (p = 0.026), minimum knee flexion angle in the second half of stance (p < 0.001), and average external rotation angle during stance (p = 0.007), and a reduction in average anterior femoral displacement during stance (p = 0.006). Comparison to healthy controls demonstrated improvement in some gait metrics over time. The results demonstrated longitudinal changes from 2 to 8 years after ACLR in knee joint kinetics and kinematics that have been related to clinical outcome after ACLR and the progression of knee OA, and support future larger and comprehensive investigations into long‐term changes in joint mechanics in the ACLR population. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1478–1486, 2018.
Paleoenvironmental change in tropical Africa during the Holocene based on a record from Lake Kifuruka, western Uganda
Authors: Kiage Lawrence M. , Howey Meghan , Hartter Joel , Palace Michael 
Published: October 2017

ABSTRACTA 10 000‐year palynological record of vegetation and environmental changes in tropical Africa is presented, based on sediment data from a 230‐cm‐long core recovered from Lake Kifuruka in western Uganda. The Lake Kifuruka record provides new sedimentary and paleoecological data for human–environment interactions and anthropogenic disturbance in the tropical African region during the Holocene. The record shows evidence for prolonged dry conditions in the region at the terminus of the last glaciation period and the onset of the Holocene period. The early Holocene and mid‐Holocene periods were characterized by largely warm and wet climatic conditions. The pollen record shows evidence of forest disturbance that is probably associated with agricultural activities near Lake Kifuruka shortly after ca. 4300BP cal a BP coinciding with a time of increased desiccation in the region. The forest disturbance in the record appears to have intensified and continued into the modern period but with no significant change in the overall vegetation diversity, suggesting quick environmental recovery. The Lake Kifuruka record is largely devoid of the abrupt climatic changes that have been observed from a couple of sites in the East African region, which implies that the changes may be site specific rather than regional scale.
A Bayesian nonparametric test of significance chasing biases
Authors: Karabatsos George 
Published: October 2017

There is a growing concern that much of the published research literature is distorted by the pursuit of statistically significant results. In a seminal article, Ioannidis and Trikalinos (2007,Clinical Trials) proposed an omnibus (I&T) test for significance chasing (SC) biases. This test compares the observed number of studies that report statistically significant results, against their expected number based on study power, assuming a common effect size across studies. The current article extends this approach by developing a Bayesian nonparametric (BNP) meta‐regression model and test of SC bias, which can diagnose bias at the individual study level. This new BNP test is based on a flexible model of the predictive distribution of study power, conditionally on study‐level covariates which account for study diversity, including diversity due to heterogeneous effect sizes across studies. A test of SC bias proceeds by comparing each study's significant outcome report indicator against its estimated posterior predictive distribution of study power, conditionally on the study's covariates. The BNP model and SC bias test are illustrated through the analyses of 3 meta‐analytic data sets and through a simulation study. Software code for the BNP model and test, and the data sets, are provided asSupporting Information.
Founder effects determine the genetic structure of the water flea Daphnia in Ethiopian reservoirs
Authors: Haileselasie Tsegazeabe H. , Mergeay Joachim , Vanoverbeke Joost , Orsini Luisa , De Meester Luc 
Published: October 2017

AbstractFounder effects introduce stochasticity in the genetic structure of species at the regional scale. To the extent that founder effects are important, they will result in a reduced signature of space, time, and environmental variation in landscape genetic data. We studied the metapopulation genetic structure of recently founded populations of the microcrustacean Daphnia sinensis in 10 Ethiopian water reservoirs. We used three different approaches to estimate the number of effective founders and applied them to two independent genetic marker sets in an effort to investigate the role of founder effects and to estimate effective size of the founding population. Estimates of founding sizes rarely exceeded eight individuals but were most often limited to less than four individuals. No associations of genetic identities, gene frequencies, measures of genetic diversity, or differentiation with environmental and spatial variables were found. Age and size of the reservoirs were not correlated with genetic diversity measures or number of founders in these reservoirs. These findings indicate that neither strong selection, nor dispersal limitation are responsible for the observed pattern of genetic variation. Our results suggest a regional population structure that is strongly impacted by founder events, reflecting colonization by just a few founders per waterbody, and not noticeably influenced by subsequent dispersal and gene flow. Our results show that rapid colonization of empty habitats and fast population growth by a handful of founders can result in strong founder effects, even in relatively large habitats that are likely regularly reached by new immigrants.