bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal analysis of masticatory system arising from malocclusion: literature review
Authors: Casarin C. , Palma R. , Arsa G. , Andrade E. , Leite G. , Bocalini D. , Serra A. , Suzuki F. , Caria P. 
Published: July 2016

Abstract
Introduction: The malocclusion can be defined as any change in the natural position of contact between the teeth and the arcades format that affects the morphofunctional architecture of the masticatory system of individuals affected by such condition. The aim of this study was to review the literature and to investigate the morphofunctional changes of the mandible and masticatory muscles as result of malocclusion. Material and Methods: This study consisted of a systematic review and the search for the theoretical composition was performed in the Lilacs, PubMed and Scielo database using as descriptors the words Malocclusion, Mandible, Masticatory Muscles and as filters the words Abstract Available, English Language, Humans, Rats. Results: This research allowed the authors to assert that the occlusal alterations are capable of causing morphological and functional modifications in the mandible and masticatory muscles. Conclusion: Given these aspects, it was possible to highlight the malocclusion as an aggravating factor at quality of life.
Optical laboratory facilities at the Finnish Meteorological Institute – Arctic Research Centre
Authors: Lakkala Kaisa , Suokanerva Hanne , Karhu Juha Matti , Aarva Antti , Poikonen Antti , Karppinen Tomi , Ahponen Markku , Hannula Henna-Reetta , Kontu Anna , Kyrö Esko 
Published: July 2016

Abstract. This paper describes the laboratory facilities at the Finnish Meteorological Institute – Arctic Research Centre (FMI-ARC, http://fmiarc.fmi.fi). They comprise an optical laboratory, a facility for biological studies, and an office. A dark room has been built, in which an optical table and a fixed lamp test system are set up, and the electronics allow high-precision adjustment of the current. The Brewer spectroradiometer, NILU-UV multifilter radiometer, and Analytical Spectral Devices (ASD) spectroradiometer of the FMI-ARC are regularly calibrated or checked for stability in the laboratory. The facilities are ideal for responding to the needs of international multidisciplinary research, giving the possibility to calibrate and characterize the research instruments as well as handle and store samples.
Retinal Nerve Fiber and Optic Disc Morphology Using Spectral-Domain Optical Coherence Tomography in Scleroderma Patients
Authors: Sahin-Atik Sevinc , Koc Feray , Akin-Sari Sirin , Ozmen Mustafa 
Published: July 2016

Purpose To evaluate the optic nerve head parameters and peripapillary retinal nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in a systemic sclerosis (SSc) cohort and age-matched controls to determine whether SSc patients have an increased risk of normal-tension glaucoma (NTG). Methods We examined 30 patients (3 male, 27 female) with SSc and 28 age- and sex-matched controls. Retinal nerve fiber and optic disc morphology were evaluated using Cirrus SD-OCT. Results Optic disc morphology measurements including disc area, rim area, average and vertical cup/disc (C/D) ratio, and cup volume were not significantly different between the study groups. The average and 4-quadrant retinal nerve fiber layer (RNFL) measurements of the C/D >0.3 subgroups were not significantly different in the patients and controls. These values were also similar for the C/D >0.5 subgroups except that the average inferior quadrant RNFL thickness of the right eyes in the patient subgroup was significantly thinner than in the control subgroup (p<0.05). Conclusions Our SSc cohort had relatively shorter disease duration but increased prevalence of early glaucomatous damage signs. Our findings indicate that SSc is a risk factor for developing normal-tension glaucoma. Further studies combined with visual field evaluation are necessary to identify the long-term glaucomatous effects of SSc.
Hypotonic Maculopathy Secondary to Scleral Defect in Atypical Retinochoroidal Coloboma
Authors: Fiore Tito , Pellegrino Adriana , Lupidi Marco , Cerquaglia Alessio , Giansanti Fabrizio , Cagini Carlo 
Published: July 2016

Purpose To describe a patient with unilateral hypotonic maculopathy and optic disc edema after spontaneous bulbar perforation of a full-thickness scleral defect. Methods An 11-year-old girl underwent scleral buckling surgery. Preoperative and postoperative evaluation included optical coherence tomography and high-resolution 3T magnetic resonance imaging. Results The scleral defect was covered with Tenon capsule sheaths and a meridional silicone buckle. One year postoperatively, visual acuity and macular and optic disc morphology were completely restored. Conclusions Ocular hypotony related to a defect of the sclera forming the roof of a retinochoroidal coloboma is a rare event. Hypotony was a consequence of a defect at the level of an atypical retinochoroidal coloboma where the scleral wall was found to be absent.
A Randomized, Controlled Study of the Efficacy and Safety of a New Eyedrop Formulation for Moderate to Severe Dry Eye Syndrome
Authors: Chiambaretta Frédéric , Doan Serge , Labetoulle Marc , Rocher Nicolas , El Fekih Lamia , Messaoud Riadh , Khairallah Moncef , Baudouin Christophe ,   for the HA-trehalose Study Group
Published: July 2016

Purpose This study compared the efficacy and safety of hyaluronic acid (HA)-trehalose, a new eyedrop containing trehalose (a natural bioprotectant) and HA, to an established formulation containing only HA. Methods This was a phase III, randomized, active-controlled, investigator-masked, multicenter study in France and Tunisia. In all, 105 adult patients (≥18 years) with moderate to severe dry eye disease (DED) received either HA-trehalose (n = 52) or HA (n = 53) 3-6 times per day for 84 days. The primary efficacy variable was the Oxford grading score at day 35. A questionnaire on dry eye and symptoms, Schirmer test, tear break-up time, conjunctival hyperemia, and global performance were assessed as secondary efficacy criteria at baseline, day 35, and day 84. Safety assessments were standard. Results Noninferiority of HA-trehalose to HA for keratoconjunctivitis sicca assessed by Oxford grading score was demonstrated at day 35. For the secondary efficacy parameters, reductions in dry eye questionnaire classes of none or mild at day 84, dry eye symptoms of stinging, itching, and blurred vision at day 35, and investigator (days 35 and 84) and patient assessments (day 35) of global performance were significantly better for HA-trehalose. There were no clinically meaningful differences between groups for the other secondary criteria. Both treatments were well-tolerated, and there were fewer ocular symptoms upon instillation and fewer adverse events for HA-trehalose than for HA. Conclusions Hyaluronic acid-trehalose is effective and safe, with better patient satisfaction, than existing HA-only eyedrops particularly from the first month of treatment, and offers a therapeutic advancement in the treatment of moderate to severe DED.
Bilateral Central Serous Retinopathy in a Patient with Paroxysmal Nocturnal Hemoglobinuria Treated with Deferoxamine
Authors: Vahdani Kaveh , Makrygiannis Georgios , Kaneshyogan Harikesh , Sian Inderpaul S. , Giasin Osama 
Published: July 2016

Purpose To report a case of acute bilateral central serous retinopathy associated with deferoxamine therapy in the context of paroxysmal nocturnal hemoglobinuria. Methods Spectral-domain optical coherence tomography and fundus autofluorescence were used to investigate posterior segment changes. Results A 76-year-old man with paroxysmal nocturnal hemoglobinuria and hereditary spherocytosis was started on deferoxamine for iron overload secondary to previous blood transfusions. Four days after initiation of treatment, he developed bilateral reduced vision and metamorphopsia. He was noted to have bilateral central serous retinopathy. Symptoms and serous retinal detachment resolved rapidly following discontinuation of treatment. Conclusions This case represents the first report of acute bilateral central serous retinopathy associated with deferoxamine therapy. Cessation of deferoxamine resulted in rapid visual recovery.
Accelerated Corneal Crosslinking for Treatment of Progressive Keratoconus in Pediatric Patients
Authors: Ulusoy Döndü M. , Göktaş Emre , Duru Necati , Özköse Ayşe , Ataş Mustafa , Yuvacı İsa , Arifoğlu Hasan B. , Zararsız Gökmen 
Published: July 2016

Purpose To evaluate the safety and efficacy of accelerated corneal crosslinking (CXL) in patients with progressive keratoconus aged 18 years or less. Methods A total of 28 eyes from 19 patients with progressive keratoconus aged 18 years or less were enrolled. We divided participants into 2 groups according to corneal thickness (CT). Group 1 included 13 eyes of 8 patients with CT ≥450 µm; group 2 included 15 eyes of 11 patients with CT <450 µm. Each participant underwent accelerated CXL using 10-minute ultraviolet A irradiance at 9 mW/cm2 for a total energy dose of 5.4 J/cm2. The efficacy and safety of the procedure were assessed postoperatively at 1, 3, 6, and 12 months with Pentacam and visual acuity. Results In uncorrected visual acuity, group 1 showed a statistically significant +0.12 logMAR improvement at 3 months postoperatively (p = 0.003), and in group 2, there was a statistically significant +0.3 logMAR improvement at 1 month postoperatively (p = 0.005). In best-corrected visual acuity, there was a +0.15 logMAR (p<0.001) and +0.22 logMAR (p = 0.005) improvement in group 1 and group 2, respectively, at 12 months postoperatively. All mean keratometric values including K1 and K2 dropped by at least 1 D or remained stable (< ± 1 D) in both groups after accelerated CXL treatment. Conclusions The findings showed that accelerated CXL treatment seems to be effective in slowing or halting the progression of keratoconus and that no permanent apparent complications are noted 6 months after accelerated CXL.
Systemic Effects of Cobalt Toxicity after Revision Hip Replacement can Manifest in Intermediate to Long Term Follow-Up
Authors: Vasukutty Nijil L. , Minhas Tahawwar Hasnat Ahmad 
Published: July 2016

Introduction Metal toxicity from metal-on-metal hip replacements is now well documented and several large series have reported local reactions. Although less common, there are reports of similar reactions from failed ceramic liners. Systemic effects documented in literature have been grouped into cardiac, neuro-ocular and thyroid signs. Methods and results We report a case of a patient who had revision for fractured ceramic liner to metal on polyethylene. Third body effect of the ceramic particles led to wear through of the poly liner and the head directly articulating with metal shell. He developed cardiac and neurological features of cobalt toxicity in addition to extensive soft tissue destruction. Revision of the bearing surfaces and synovectomy led to clinical improvement and fall in metal ion levels. Conclusions We recommend 2-stage revision in such situations and close monitoring of all these patients.
Fracture of a Spline of the Femoral Stem in an Ingrown Modular Hip Implant
Authors: McNabb David Clinton , Jennings Jason M. , Dennis Douglas A. 
Published: July 2016

Introduction Physiologic strain patterns of the femur are altered by the bending stiffness of the implant as well as the loading pattern of the implant itself. The Savish Range of Motion (S-ROM) femoral stem has been designed with flutes (to decrease distal material) and with a coronal slot (to decrease stiffness). Materials The purpose of this case report is to briefly discuss design characteristics of femoral stems and their relationship to thigh pain as well as to describe the only report in the literature of a fracture of the anterior spline of a S-ROM prosthesis at the coronal slot. Results The femoral stem fractured at the coronal slot due to multiple bending moments in a small diameter stem. Conclusions The proximal metaphyseal sleeve remains well fixed and the patient is functioning well without pain nearly a year after the identification of the fracture on routine follow-up.
Quality of Life after Staged Revision for Infected Total Hip Arthroplasty: A Systematic Review
Authors: Rietbergen Luuk , Kuiper Jesse W.P. , Walgrave Simon , Hak Laura , Colen Sascha 
Published: July 2016

Introduction The aim of this review was to assess (health-related) quality of life ([HR]Qol) after 1-stage or 2-stage revision for prosthetic joint infection of the hip (PJI). Additionally, we compared (HR)QoL scores with normative population scores to assess whether QoL is reduced after revision for PJI. Methods A systematic search was performed in Embase, Cochrane and Pubmed. We included articles that reported (HR)QoL questionnaires after staged revision for hip PJI with a minimum follow-up of 24 months. Methodological quality was assessed using the MINORS score. Results The search produced 11,195 results. We selected 12 papers describing 2-stage revisions. The mean MINORS score was 9.8. Average WOMAC scores of 185 patients with a mean follow-up of 69.8 months were 73. Average Short Form 36 (SF-36) scores of 159 patients with a mean follow-up of 40.7 months were 40.4 for the physical component score (PCS) and 51.6 for the mental component score (MCS). Average Short Form 12 (SF-12) scores of 154 patients with a mean follow-up of 73.4 months were: a PCS of 35.4 and a MCS of 49.1. The WOMAC, SF-12 (PCS) and SF-36 (PCS) were respectively 12%, 26.7% and 14.8% lower, compared to normative values. Discussions Patients who underwent 2-stage revision for hip PJI had substantially lower (physical component) (HR)QoL scores, but mental scores were comparable to the general population.
The Role of Midkine in the Inflammatory Process and Its Correlation with Other Inflammatory Markers in Renal Transplant Recipients
Authors: Uzun Sami , Kaya Burcu , Celik Kenan , Behlul Ahmet , Ozkan Oktay , Kuvvet Melike , Doventas Yasemin Erdogan , Gursu Meltem , Karadag Serhat , Sumnu Abdullah , Cebeci Egemen , Kocak Burak , Turkmen Aydin , Ozturk Savas 
Published: July 2016

Background Midkine (MK), which is expressed in the proximal tubular epithelial cells of the kidney, is thought to have a role in the pathophysiology of inflammation-related renal diseases. Both immunological and nonimmunological mechanisms may affect renal functions negatively during the early and late post-transplantation periods. We aimed in our study to evaluate the relationship of MK with clinical findings and inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), interleukin (IL-6) and tumor necrosis factor (TNF-α) in the pretransplant and post-transplant period. Methods Forty-one consecutive patients transplanted from living related donors were included in this prospective observational study. All patients received the same immunosuppressive treatment protocol. MK, hsCRP, IL-6 and TNF-α levels were measured before and 2 months after renal transplantation. Results Pretransplant MK levels correlated positively with hsCRP (r = 0.41, p = 0.004) and IL-6 (r = 0.58, p<0.001). The mean post-transplant MK level was found to be higher than the pretransplant level (143 ± 350 pg/mL, 2792 ± 4235 pg/mL respectively, p = <0.001), while the mean hsCRP, IL-6 and TNF-α levels did not change significantly. Post-transplant IL-6 correlated significantly with MK (r = 0.388, p = 0.012), hsCRP (r = 0.41, p = 0.007) and TNF-α (r = 0.348, p = 0.026). There was no significant correlation between clinical findings and inflammatory markers. Conclusions MK may be a good inflammatory marker in renal transplant recipients as in other inflammatory diseases. Moreover, it seems that it is not affected by factors other than inflammation during the post-transplantation period.
The Effect of Scaffold Pore Size in Cartilage Tissue Engineering
Authors: Nava Michele M. , Draghi Lorenza , Giordano Carmen , Pietrabissa Riccardo 
Published: July 2016

Introduction The effect of scaffold pore size and interconnectivity is undoubtedly a crucial factor for most tissue engineering applications. The aim of this study was to examine the effect of pore size and porosity on cartilage construct development in different scaffolds seeded with articular chondrocytes. Methods We fabricated poly-L-lactide- co-trimethylene carbonate scaffolds with different pore sizes, using a solvent-casting/particulate-leaching technique. We seeded primary bovine articular chondrocytes on these scaffolds, cultured the constructs for 2 weeks and examined cell proliferation, viability and cell-specific production of cartilaginous extracellular matrix proteins, including GAG and collagen. Results Cell density significantly increased up to 50% with scaffold pore size and porosity, likely facilitated by cell spreading on the internal surface of bigger pores, and by increased mass transport of gases and nutrients to cells, and catabolite removal from cells, allowed by lower diffusion barriers in scaffolds with a higher porosity. However, both the cell metabolic activity and the synthesis of cartilaginous matrix proteins significantly decreased by up to 40% with pore size. We propose that the association of smaller pore diameters, causing 3-dimensional cell aggregation, to a lower oxygenation caused by a lower porosity, could have been the condition that increased the cell-specific synthesis of cartilaginous matrix proteins in the scaffold with the smallest pores and the lowest porosity among those tested. Conclusions In the initial steps of in vitro cartilage engineering, the combination of small scaffold pores and low porosity is an effective strategy with regard to the promotion of chondrogenesis.
Low RAP80 mRNA Expression Correlates with Shorter Survival in Sporadic High-Grade Serous Ovarian Carcinoma
Authors: Romeo Margarita , Karachaliou Niki , Chaid Imane , Queralt Cristina , De Aguirre Itziar , Gómez María del Carmen , Sanchez-Ronco María , Radua Joaquim , Ramírez José Luís , Rosell Rafael 
Published: July 2016

Objective Homologous recombination (HR) is frequently impaired in sporadic high-grade serous ovarian carcinoma (sHGSOC) due to deficiencies in BRCA1/2 genes, a situation associated with hypersensitivity to platinum compounds. Alterations in other genes can also cause HR deficiency. Preclinical data show that RAP80 is an HR–pathway-related gene that influences BRCA1 activity. RAP80 has been reported to affect outcome in some solid neoplasms. This study investigates the role of RAP80 in sHGSOC survival. Methods mRNA expression of RAP80 was analyzed in tumor samples from 35 patients who postoperatively received standard platinum-based chemotherapy. The effects of RAP80 expression on progression-free survival (PFS) and overall survival (OS) were examined by means of Cox regressions. The clinical variables known to have prognostic value (FIGO stage, residual disease at surgery, and debulking surgery) were included as covariates in the analysis. BRCA1 was analyzed given the moderate correlations with RAP80. Results Median follow-up, PFS and OS were 61.3, 20.2 and 62.8 months, respectively. Low RAP80 expression levels were associated with shorter PFS ( HR = 1.449, p = 0.007) and OS ( HR = 1.331, p = 0.047). Conclusions This is the first study to show a potential prognostic role of RAP80 expression in patients with HGSOC. The results suggest that HR deficiency due to low RAP80 expression is not associated with hypersensitivity to platinum compounds in sHGSOC.
The Risk of Bleeding with Tunneled Dialysis Catheter Placement
Authors: Beathard Gerald A. , Urbanes Aris , Litchfield Terry 
Published: July 2016

Purpose The purpose of this study was to evaluate the risk of bleeding associated with tunneled dialysis catheter (TDC) placement in a large population of hemodialysis patients who were either anticoagulated or were taking antithrombotic medications. Methods Medical records obtained over a two-year period were queried in order to select two groups of study cases. The first was a Med group (n = 458), cases which had a TDC placed while taking the antithrombotic medications (warfarin, clopidogrel or acetylsalicylic acid [ASA]) which were not discontinued or held. The second was a Declot Failure (DF) group (n = 941) and consisted of cases in which a TDC had been placed immediately following a failed arteriovenous access thrombectomy procedure in which they had been anticoagulated using unfractionated heparin. The results obtained in these two groups were compared to the incidence of bleeding observed in a cohort of 6555 TDC placements that had been performed previously referred to as the Control group. Results The incidence of bleeding in the Control group was 0.46%. The incidence of bleeding in the DF group was 0.44% and in the Med group was 0.36%. No patient had bleeding that required transfusion, hospitalization, or catheter removal. Conclusions Based upon these data, it seems reasonable to classify the TDC placement procedure as having a very low risk of bleeding and to not require preprocedure laboratory testing. The value of suspending antithrombotic medications prior to TDC placement cannot be supported.
Feasibility and Benefit of Concurrent Chemoradiotherapy for Elderly Patients with Uterine Cervical Cancer
Authors: Nosaka Kazuto , Shibata Kiyosumi , Utsumi Fumi , Yoshida Kosuke , Niimi Kaoru , Sekiya Ryuichiro , Suzuki Shiro , Kajiyama Hiroaki , Kikkawa Fumitaka 
Published: July 2016

Background Elderly patients with uterine cervical cancer reportedly have a poorer prognosis than younger patients. Until now, the benefit of concurrent chemoradiotherapy (CCRT) for elderly patients has been considered limited. Methods We retrospectively analyzed 49 women with cervical cancer aged >70 years primarily treated with radiotherapy (RT) or CCRT in our institute between 2003 and 2014. Treatment compliance, toxicity, and survival benefit were analyzed. Results A total of 49 patients were identified in this retrospective analysis. Twenty patients with a median age of 75.4 years (range 70–77) were treated with CCRT and 29 patients with a median age of 77.9 years (range 70–89) underwent RT. In the CCRT group, 14 patients (70%) completed CCRT consisting of radiotherapy and 5 courses of cisplatin plus 5-fluorouracil including patients requiring a dose reduction of chemotherapy. The median overall survival (OS) in the CCRT and RT groups was 66.9 and 60.1 months, respectively (p = 0.156). The most common grade 3/4 acute toxicity was hyponatremia (35.0%), followed by neutropenia (15.0%) and diarrhea (10.0%) in the CCRT group, while this was anemia (17.2%) followed by radiation enteritis (10.3%) in the RT group. Conclusions CCRT was well tolerated in elderly patients with cervical cancer. Careful attention should be paid to the different characteristics of treatment-related toxicities in this group compared with younger patients.