bluuebunny/crossref_metadata_2025_split huggingface dataset:
Une littérature sous influence
Authors: Saint-Jacques Denis 
Published: August 2016

Dans cet article, l’auteur s’attache à éclairer les conditions de production et de distribution déterminant le profond changement qui affecte le champ de la fiction littéraire au Québec durant les années de la Deuxième Guerre mondiale, alors que la littérature légitime ne semble que peu portée à thématiser explicitement la conjoncture. Cet examen touche brièvement la poésie et le théâtre, porte principalement sur les romans ou récits brefs publiés en volumes, mais également sur ceux publiés en périodiques et en fascicules, ainsi que sur ceux diffusés à la radio. Le champ mis en cause comporte donc le circuit restreint et celui de grande diffusion. L’enquête permet de voir que, si la littérature légitime se réoriente de façon décisive vers des sujets plus « urbains » et une esthétique nouvelle, « l’introspection », la fiction radiophonique tant narrative que lyrique exploite opportunément les thèmes aussi bien militaires que civils fournis par la conjoncture immédiate. Elle permet de comprendre que, pour une bonne part, ces évolutions se trouvent fortement déterminées par les nouvelles conditions de diffusion qui s’organisent à cette époque et que la guerre, quand elle apparaît comme sujet explicite de représentation, doit cette visibilité à des demandes expresses.
Vers une reconstitution de la vie culturelle des femmes à Montréal dans les années 19401
Authors: Savoie Chantal 
Published: August 2016

Dans la perspective de ce dossier, qui vise à saisir les contours de la rupture littéraire de la décennie 1940 et qui réinterroge les « classiques », mais aussi et peut-être surtout les manifestations trop souvent considérées comme illégitimes par la critique, cet article s’intéresse à la culture féminine qui se déploie alors dans l’espace urbain. Se basant sur des dépouillements de la grande presse de l’époque et sur l’interprétation de nouvelles données statistiques et géolocalisées, l’analyse cherche à cartographier les trajectoires, les réseaux et la production des femmes de cette génération, hors des institutions et en marge du champ restreint. Elle permet ainsi de jeter un regard neuf sur la constitution de l’offre et des publics populaires dans la première moitié du xxe siècle, et pose les bases d’une réflexion sur l’émergence d’une culture moyenne.
Quand Refus global devient « Refus global »
Authors: Dubois Sophie 
Published: August 2016

Souvent retenu comme l’amorce de la modernité culturelle québécoise, le manifeste automatiste Refus global est examiné dans cet article du point de vue de sa première réception (1948-1949). Sont interrogés les critères sociohistoriques et esthétiques privilégiés à la fin des années 1940 ayant permis à l’oeuvre d’acquérir le statut de texte fondateur grâce à un resserrement du discours critique autour du texte éponyme, au détriment des autres composantes du recueil original. Une étude de la centaine d’articles formant la première réception révèle que cinq facteurs principaux jouent un rôle dans la lecture faite de l’oeuvre et dans le statut qui lui est octroyé : la matérialité du recueil original, l’état des champs artistiques, les critères de légitimité établis par la critique, la réaction étatique et l’attitude des auteurs envers la critique. Chacun de ces facteurs est analysé et historicisé par l’auteure, qui montre comment, à l’époque, une oeuvre recueillistique et pluridisciplinaire comme Refus global bouleverse l’horizon d’attente, entre autres en allant à contresens de la logique moderniste, malgré ce que la critique en a retenu. L’étude de la première réception permet ainsi à la fois d’expliquer la réduction du discours critique ayant conduit à la consécration du texte éponyme « Refus global » et de mettre en évidence d’autres lectures, faites avant la constitution du discours dominant ou en parallèle avec celui-ci, susceptibles de réévaluer le statut aujourd’hui attribué à l’oeuvre.
Influence of large‐scale atmospheric circulation on marine air intrusion toward the East Antarctic coast
Authors: Kurita Naoyuki , Hirasawa Naohiko , Koga Seizi , Matsushita Junji , Steen‐Larsen Hans Christian , Masson‐Delmotte Valérie , Fujiyoshi Yasushi 
Published: August 2016

AbstractMarine air intrusions into Antarctica play a key role in high‐precipitation events. Here we use shipboard observations of water vapor isotopologues between Australia and Syowa on the East Antarctic coast to elucidate the mechanism by which large‐scale circulation influences marine air intrusions. The temporal isotopic variations at Syowa reflect the meridional movement of a marine air front. They are also associated with atmospheric circulation anomalies that enhance the southward movement of cyclones over the Southern Ocean. The relationship between large‐scale circulation and the movement of the front is explained by northerly winds which, in association with cyclones, move toward the Antarctic coast and push marine air with isotopically enriched moisture into the inland covered by glacial air with depleted isotopic values. Future changes in large‐scale circulation may have a significant impact on the frequency and intensity of marine air intrusion into Antarctica.
The response of clouds and aerosols to cosmic ray decreases
Authors: Svensmark J. , Enghoff M. B. , Shaviv N. J. , Svensmark H. 
Published: August 2016

AbstractA method is developed to rank Forbush decreases (FDs) in the galactic cosmic ray radiation according to their expected impact on the ionization of the lower atmosphere. Then a Monte Carlo bootstrap‐based statistical test is formulated to estimate the significance of the apparent response in physical and microphysical cloud parameters to FDs. The test is subsequently applied to one ground‐based and three satellite‐based data sets. Responses (>95%) to FDs are found in the following parameters of the analyzed data sets. AERONET: Ångström exponent (cloud condensation nuclei changes), SSM/I: liquid water content, International Satellite Cloud Climate Project (ISCCP): total, high, and middle, IR‐detected clouds over the oceans, Moderate Resolution Imaging Spectroradiometer (MODIS): cloud effective emissivity, cloud optical thickness, liquid water, cloud fraction, liquid water path, and liquid cloud effective radius. Moreover, the responses in MODIS are found to correlate positively with the strength of the FDs, and the signs and magnitudes of the responses agree with model‐based expectations. The effect is mainly seen in liquid clouds. An impact through changes in UV‐driven photo chemistry is shown to be negligible and an impact via UV absorption in the stratosphere is found to have no effect on clouds. The total solar irradiance has a relative decrease in connection with FDs of the order of 10−3, which is too small to have a thermodynamic impact on timescales of a few days. The results demonstrate that there is a real influence of FDs on clouds probably through ions.
Gold‐Catalyzed Formal [4+1]/[4+3] Cycloadditions of Diazo Esters with Triazines
Authors: Zhu Chenghao , Xu Guangyang , Sun Jiangtao 
Published: August 2016

AbstractReported herein is the unprecedented gold‐catalyzed formal [4+1]/[4+3] cycloadditions of diazo esters with hexahydro‐1,3,4‐triazines, thus providing five‐ and seven‐membered heterocycles in moderate to high yields under mild reaction conditions. These reactions feature the use of a gold complex to accomplish the diverse annulations and the first example of the involvement of a gold metallo‐enolcarbene in a cycloaddition. It is also the first utilization of stable triazines as formal dipolar adducts in the carbene‐involved cycloadditions. Mechanistic investigations reveal that the triazines reacted directly, rather than as formaldimine precursors, in the reaction process.
Application of polymeric high‐internal‐phase‐emulsion‐coated stationary‐phase columns in open‐tubular capillary electrochromatography
Authors: Choudhury Sidratul , Connolly Damian , White Blánaid 
Published: August 2016

ABSTRACTThe application of polymeric high‐internal‐phase emulsion (polyHIPE) capillary coatings for open‐tubular analytical separation columns was demonstrated in this study for the first time. Multiple polystyrene‐co‐divinylbenzene polyHIPE layers with an average total depth of 1.73 µm were coated onto internal capillary surfaces to create open‐tubular columns (20 cm coating and 32.5 cm effective length). With these columns for open‐tubular capillary electrochromatography, ethylbenzene and pentylbenzene were separated. Although the overall separation capacity of the produced columns was low, the polyHIPE coatings improved the analyte peak shape, decreased the total run time, and improved the peak symmetries relative to comparable unmodified open‐tubular columns. In addition, the use of these novel polyHIPE columns led to the use of 30% less organic modifier. These columns have the potential to improve the shelf life of open‐tubular columns typically used in capillary electrochromatography. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44237.
Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications
Authors: Coppock Matthew B. , Warner Candice R. , Dorsey Brandi , Orlicki Joshua A. , Sarkes Deborah A. , Lai Bert T. , Pitram Suresh M. , Rohde Rosemary D. , Malette Jacquie , Wilson Jeré A. , Kearney Paul , Fang Kenneth C. , Law Scott M. , Candelario Sherri L. , Farrow Blake , Finch Amethist S. , Agnew Heather D. , Heath James R. , Stratis‐Cullum Dimitra N. 
Published: August 2016

AbstractWe report on peptide‐based ligands matured through the protein catalyzed capture (PCC) agent method to tailor molecular binders for in vitro sensing/diagnostics and in vivo pharmacokinetics parameters. A vascular endothelial growth factor (VEGF) binding peptide and a peptide against the protective antigen (PA) protein of Bacillus anthracis discovered through phage and bacterial display panning technologies, respectively, were modified with click handles and subjected to iterative in situ click chemistry screens using synthetic peptide libraries. Each azide‐alkyne cycloaddition iteration, promoted by the respective target proteins, yielded improvements in metrics for the application of interest. The anti‐VEGF PCC was explored as a stable in vivo imaging probe. It exhibited excellent stability against proteases and a mean elimination in vivo half‐life (T1/2) of 36 min. Intraperitoneal injection of the reagent results in slow clearance from the peritoneal cavity and kidney retention at extended times, while intravenous injection translates to rapid renal clearance. The ligand competed with the commercial antibody for binding to VEGF in vivo. The anti‐PA ligand was developed for detection assays that perform in demanding physical environments. The matured anti‐PA PCC exhibited no solution aggregation, no fragmentation when heated to 100°C, and  > 81% binding activity for PA after heating at 90°C for 1 h. We discuss the potential of the PCC agent screening process for the discovery and enrichment of next generation antibody alternatives.
Grey matter abnormalities in methcathinone abusers with a Parkinsonian syndrome
Authors: Juurmaa Julius , Menke Ricarda A. L. , Vila Pierre , Müürsepp Andreas , Tomberg Tiiu , Ilves Pilvi , Nigul Mait , Johansen‐Berg Heidi , Donaghy Michael , Stagg Charlotte J. , Stepens Ainārs , Taba Pille 
Published: August 2016

AbstractBackgroundA permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1‐weighted MRI.MethodsWe have investigated brain structure and function in methcathinone abusers (n = 12) compared to matched control subjects (n = 12) using T1‐weighted structural and resting‐state functional MRI.ResultsSegmentation analysis revealed significant (p < .05) subcortical grey matter atrophy in methcathinone abusers within putamen and thalamus bilaterally, and the left caudate nucleus. The volume of the caudate nuclei correlated inversely with duration of methcathinone abuse. Voxel‐based morphometry showed patients to have significant grey matter loss (p < .05) bilaterally in the putamina and caudate nucleus. Surface‐based analysis demonstrated nine clusters of cerebral cortical thinning in methcathinone abusers, with relative sparing of prefrontal, parieto‐occipital, and temporal regions. Resting‐state functional MRI analysis showed increased functional connectivity within the motor network of patients (p < .05), particularly within the right primary motor cortex.ConclusionTaken together, these results suggest that the manganese exposure associated with prolonged methcathinone abuse results in widespread structural and functional changes affecting both subcortical and cortical grey matter and their connections. Underlying the distinctive movement disorder caused by methcathinone abuse, there is a more widespread pattern of brain involvement than is evident from the hyperintensity restricted to the basal ganglia as shown by T1‐weighted structural MRI.
Dissociable roles of medial and lateral PFC in rule learning
Authors: Cao Bihua , Li Wei , Li Fuhong , Li Hong 
Published: August 2016

AbstractIntroductionAlthough the neural basis of rule learning is of great interest to cognitive neuroscientists, the pattern of transient brain activation during rule discovery remains to be investigated.MethodIn this study, we measured event‐related functional magnetic resonance imaging (fMRI) during distinct phases of rule learning. Twenty‐one healthy human volunteers were presented with a series of cards, each containing a clock‐like display of 12 circles numbered sequentially. Participants were instructed that a fictitious animal would move from one circle to another either in a regular pattern (according to a rule hidden in consecutive trials) or randomly. Participants were then asked to judge whether a given step followed a rule.ResultsWhile the rule‐search phase evoked more activation in the posterior lateral prefrontal cortex (LPFC), the rule‐following phase caused stronger activation in the anterior medial prefrontal cortex (MPFC). Importantly, the intermediate phase, the rule‐discovery phase evoked more activations in MPFC and dorsal anterior cingulate cortex (dACC) than rule search, and more activations in LPFC than rule following.ConclusionTherefore, we can conclude that the medial and lateral PFC have dissociable contributions in rule learning.
Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G‐Quadruplex in the Solid State
Authors: Mandal Pradeep K. , Baptiste Benoît , Langlois d'Estaintot Béatrice , Kauffmann Brice , Huc Ivan 
Published: August 2016

AbstractQuinoline‐based oligoamide foldamers have been identified as a potent class of ligands for G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or grooves and not G‐tetrads. We report a co‐crystal structure of the antiparallel hairpin dimeric DNA G‐quadruplex (G4T4G4)2 with tetramer 1—a helically folded oligo‐quinolinecarboxamide bearing cationic side chains—that is consistent with this hypothesis. Multivalent foldamer–DNA interactions that modify the packing of (G4T4G4)2 in the solid state are observed.
Ternary PtRuPd/C Catalyst for High‐Performance, Low‐Temperature Direct Dimethyl Ether Fuel Cells
Authors: Dumont Joseph H. , Martinez Ulises , Chung Hoon T. , Zelenay Piotr 
Published: August 2016

AbstractDimethyl ether (DME) is a promising alternative fuel option for direct‐feed low‐temperature fuel cells. Until recently, DME had not received the same attention as alcohol fuels, such as methanol or ethanol, despite its notable advantages. These advantages include a high theoretical open‐cell voltage (1.18 V at 25 °C) that is similar to that of methanol (1.21 V), much lower toxicity than methanol, and no need for the carbon−carbon bond scission that is needed in ethanol oxidation. DME is biodegradable, has a higher energy content than methanol (8.2 vs. 6.1 kWh kg−1), and, like methanol, can be synthesized from recycled carbon dioxide. Although the performance of direct DME fuel cells (DDMEFCs) has progressed over the past few years, DDMEFCs have not been viewed as fully viable. In this work, we report much improved performance from the ternary Pt55Ru35Pd10/C anode catalyst, allowing DDMEFCs to compete directly with direct methanol fuel cells (DMFCs). We also report results involving binary Pt alloys as reference catalysts and an in situ infrared electrochemical study to better understand the mechanism of DME electro‐oxidation on ternary PtRuPd/C catalysts.
Self‐Assembled Cyclic d,l‐α‐Peptides as Generic Conformational Inhibitors of the α‐Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies
Authors: Chemerovski‐Glikman Marina , Rozentur‐Shkop Eva , Richman Michal , Grupi Asaf , Getler Asaf , Cohen Haim Y. , Shaked Hadassa , Wallin Cecilia , Wärmländer Sebastian K. T. S. , Haas Elisha , Gräslund Astrid , Chill Jordan H. , Rahimipour Shai 
Published: August 2016

AbstractMany peptides and proteins with large sequences and structural differences self‐assemble into disease‐causing amyloids that share very similar biochemical and biophysical characteristics, which may contribute to their cross‐interaction. Here, we demonstrate how the self‐assembled, cyclic d,l‐α‐peptide CP‐2, which has similar structural and functional properties to those of amyloids, acts as a generic inhibitor of the Parkinson′s disease associated α‐synuclein (α‐syn) aggregation to toxic oligomers by an „off‐pathway“ mechanism. We show that CP‐2 interacts with the N‐terminal and the non‐amyloid‐β component region of α‐syn, which are responsible for α‐syn′s membrane intercalation and self‐assembly, thus changing the overall conformation of α‐syn. CP‐2 also remodels α‐syn fibrils to nontoxic amorphous species and permeates cells through endosomes/lysosomes to reduce the accumulation and toxicity of intracellular α‐syn in neuronal cells overexpressing α‐syn. Our studies suggest that targeting the common structural conformation of amyloids may be a promising approach for developing new therapeutics for amyloidogenic diseases.
N−H‐Type Excited‐State Proton Transfer in Compounds Possessing a Seven‐Membered‐Ring Intramolecular Hydrogen Bond
Authors: Chen Yi‐An , Meng Fan‐Yi , Hsu Yen‐Hao , Hung Cheng‐Hsien , Chen Chi‐Lin , Chung Kun‐You , Tang Wei‐Feng , Hung Wen‐Yi , Chou Pi‐Tai 
Published: August 2016

AbstractA series of compounds containing 5‐(2‐aminobenzylidene)‐2,3‐dimethyl‐3,5‐dihydro‐4H‐imidazol‐4‐one (o‐ABDI) as the core chromophore with a seven‐membered‐ring N−H‐type intramolecular hydrogen bond have been synthesized and characterized. The acidity of the N−H proton and thus the hydrogen‐bond strength can be fine‐tuned by replacing one of the amino hydrogen atoms by a substituent R, the acidity increasing with increasing electron‐withdrawing strength of R, that is, in the order H<COCH3<COPh<Tosyl<COCF3. The tosyl and trifluoroacetyl derivatives undergo ultrafast, irreversible excited‐state intramolecular proton transfer (ESIPT) that results in proton‐transfer emission solely in the red region. Reversible ESIPT, and hence dual emission, involving the normal and proton‐transfer tautomers was resolved for the acetyl‐ and benzyl‐substituted counterparts. For o‐ABDI, which has the weakest acidity, ESIPT is prohibited due to its highly endergonic reaction. The results clearly demonstrate the harnessing of ESIPT by modifying the proton acidity and hydrogen‐bonding strength in a seven‐membered‐ring intramolecular hydrogen‐bonding system. For all the compounds studied, the emission quantum yields are weak (ca. 10−3) in dichloromethane, but strong in the solid form, ranging from 3.2 to 47.4 %.
Towards Printed Organic Light‐Emitting Devices: A Solution‐Stable, Highly Soluble CuI–NHetPHOS
Authors: Wallesch Manuela , Verma Anand , Fléchon Charlotte , Flügge Harald , Zink Daniel M. , Seifermann Stefan M. , Navarro José M. , Vitova Tonya , Göttlicher Jörg , Steininger Ralph , Weinhardt Lothar , Zimmer Manuel , Gerhards Markus , Heske Clemens , Bräse Stefan , Baumann Thomas , Volz Daniel 
Published: August 2016

AbstractThe development of iridium‐free, yet efficient emitters with thermally activated delayed fluorescence (TADF) was an important step towards mass production of organic light‐emitting diodes (OLEDs). Progress is currently impeded by the low solubility and low chemical stability of the materials. Herein, we present a CuI‐based TADF emitter that is sufficiently chemically stable under ambient conditions and can be processed by printing techniques. The solubility is drastically enhanced (to 100 g L−1) in relevant printing solvents. The integrity of the complex is preserved in solution, as was demonstrated by X‐ray absorption spectroscopy and other techniques. In addition, it was found that the optoelectronic properties are not affected even when partly processing under ambient conditions. As a highlight, we present a TADF‐based OLED device that reached an efficiency of 11±2 % external quantum efficiency (EQE).
Cellular distribution of the fragile X mental retardation protein in the mouse brain
Authors: Zorio Diego A.R. , Jackson Christine M. , Liu Yong , Rubel Edwin W. , Wang Yuan 
Published: August 2016

ABSTRACTThe fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndrome (FXS). Despite FMRP importance for proper brain function, its overall expression pattern in the mammalian brain at the resolution of individual neuronal cell groups is not known. In this study we used FMR1 knockout and isogenic wildtype mice to systematically map the distribution of FMRP expression in the entire mouse brain. Using immunocytochemistry and cellular quantification analyses, we identified a large number of prominent cell groups expressing high levels of FMRP at the subcortical levels, in particular sensory and motor neurons in the brainstem and thalamus. In contrast, many cell groups in the midbrain and hypothalamus exhibit low FMRP levels. More important, we describe differential patterns of FMRP distribution in both cortical and subcortical brain regions. Almost all major brain areas contain high and low levels of FMRP cell groups adjacent to each other or between layers of the same cortical areas. These differential patterns indicate that FMRP expression appears to be specific to individual neuronal cell groups instead of being associated with all neurons in distinct brain regions, as previously considered. Taken together, these findings support the notion of FMRP differential neuronal regulation and strongly implicate the contribution of fundamental sensory and motor processing at subcortical levels to FXS pathology. J. Comp. Neurol. 525:818–849, 2017. © 2016 Wiley Periodicals, Inc.
The Role of Ligand Topology in the Decomplexation of Luminescent Lanthanide Complexes by Dipicolinic Acid
Authors: Mian Federica , Bottaro Gregorio , Seraglia Roberta , Cavazzini Marco , Quici Silvio , Armelao Lidia 
Published: August 2016

AbstractIn this study, we present the aqueous solution behavior of two luminescent lanthanide antenna complexes (Eu3+⊂1, Dy3+⊂9) with different ligand topologies in the presence of dipicolinic acid (DPA, pyridine‐2,6‐dicarboxylic acid). Macrocyclic (1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic acid, DO3A, 9) and acyclic (1,4,7‐triazaheptane‐1,1,7,7‐tetraacetic acid, DTTA, 1) ligands have been selected to form a ratiometric pair in which Dy3+⊂9 acts as a reference and Eu3+⊂1 acts as a probe for the recognition of DPA. The pair of luminescent complexes in water reveals the capability to work as a DPA luminescent sensor. The change of emission intensity of Eu3+ indicates the occurrence of a new sensitization path for the lanthanide cation through excitation of DPA. NMR evidence implies the presence of free 1 and mass spectrometry shows the formation of emitting [EuDPA2]− as a result of a ligand exchange reaction.