bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late IL-3–induced phenotypic and functional alterations in human basophils require continuous IL-3 receptor signaling
Authors: Kämpfer Sacha S , Odermatt Andrea , Dahinden Clemens A , Fux Michaela 
Published: July 2016

Abstract
Cytokines of the GM-CSF family signal via the same receptor subunit (βc) and, thus, have overlapping effects on cells that express all cytokine-specific α-chains (IL-3Rα, IL-5Rα, GM-CSFRα), such as human basophils, whose rapid effector functions are similarly enhanced by IL-3, IL-5, and GM-CSF. However, previous work has shown that IL-3, but not IL-5 and GM-CSF, supports and induces allergy-associated functions of human basophils at later time points. This includes induction of Th2 cytokine and chemokine secretion, high-affinity IgE receptor–independent leukotriene C4 (LTC4) formation, expression of enzymes (e.g., RALDH2, granzyme B), and kinases (e.g., Pim1). Here, we address the question of why IL-3, but not IL-5 or GM-CSF, is capable of inducing these late responses in human basophils, and we investigate the mechanism that underlies the unique regulatory capacity of IL-3. We find that IL-3, IL-5, and GM-CSF rapidly activate the same canonical signaling cascades in a qualitatively identical manner with comparable strength, but we identify signaling duration as major discriminating factor. IL-5 and GM-CSF rapidly down-regulate surface levels of their receptors within minutes, concomitant with a rapid decay in signaling molecule activation and time-dependent loss of ability of these cytokines to prime basophils for functional responses. By contrast, IL-3 hardly down-regulates the α-chain of its receptor without depleting the common β-chain, which enables extraordinarily sustained signaling events, predominantly the activation of Stat5. Of interest, acute IL-3 signaling is not sufficient to induce persistent phenotypical and functional changes in human basophils. Induction of these functional late responses depends on continuous IL-3 receptor activation and signaling.
Social support and protection from depression: systematic review of current findings in Western countries
Authors: Gariépy Geneviève , Honkaniemi Helena , Quesnel-Vallée Amélie 
Published: July 2016

BackgroundNumerous studies report an association between social support and protection from depression, but no systematic review or meta-analysis exists on this topic.AimsTo review systematically the characteristics of social support (types and source) associated with protection from depression across life periods (childhood and adolescence; adulthood; older age) and by study design (cross-sectionalv. cohort studies).MethodA systematic literature search conducted in February 2015 yielded 100 eligible studies. Study quality was assessed using a critical appraisal checklist, followed by meta-analyses.ResultsSources of support varied across life periods, with parental support being most important among children and adolescents, whereas adults and older adults relied more on spouses, followed by family and then friends. Significant heterogeneity in social support measurement was noted. Effects were weaker in both magnitude and significance in cohort studies.ConclusionsKnowledge gaps remain due to social support measurement heterogeneity and to evidence of reverse causality bias.
Impact of personality status on the outcomes and cost of cognitive–behavioural therapy for health anxiety
Authors: Sanatinia Rahil , Wang Duolao , Tyrer Peter , Tyrer Helen , Crawford Mike , Cooper Sylvia , Loebenberg Gemma , Barrett Barbara 
Published: July 2016

BackgroundHealth anxiety, hypochondriasis and personality disturbance commonly coexist. The impact of personality status was assessed in a secondary analysis of a randomised controlled trial (RCT).AimsTo test the impact of personality status using ICD-11 criteria on the clinical and cost outcomes of treatment with cognitive–behavioural therapy for health anxiety (CBT-HA) and standard care over 2 years.MethodPersonality dysfunction was assessed at baseline in 444 patients before randomisation and independent assessment of costs and outcomes made on four occasions over 2 years.ResultsIn total, 381 patients (86%) had some personality dysfunction with 184 (41%) satisfying the ICD criteria for personality disorder. Those with no personality dysfunction showed no treatment differences (P= 0.90) and worse social function with CBT-HA compared with standard care (P<0.03) whereas all other personality groups showed greater improvement with CBT-HA maintained over 2 years (P<0.001). Less benefit was shown in those with more severe personality disorder (P<0.05). Costs were less with CBT-HA except for non-significant greater differences in those with moderate or severe personality disorder.ConclusionsThe results contradict the hypothesis that personality disorder impairs response to CBT in health anxiety in both the short and medium term.
Quality of Patient-Provider Communication Among Cancer Survivors: Findings From a Nationally Representative Sample
Authors: Chawla Neetu , Blanch-Hartigan Danielle , Virgo Katherine S. , Ekwueme Donatus U. , Han Xuesong , Forsythe Laura , Rodriguez Juan , McNeel Timothy S. , Yabroff K. Robin 
Published: July 2016

Purpose: Although patient-provider communication is an essential component of health care delivery, little is known about the quality of these discussions among patients with cancer. Methods: Data are from the 2011 Medical Expenditure Panel Survey Experiences with Cancer survey among 1,202 adult cancer survivors. We evaluated discussions with any provider after a cancer diagnosis about: (1) follow-up care; (2) late or long-term treatment effects; (3) lifestyle recommendations, such as diet, exercise, and quitting smoking; and (4) emotional or social needs. Using a response scale ranging from “did not discuss” to “discussed in detail,” a summary score was constructed to define communication quality as high, medium, or low. Patient factors associated with the quality of provider discussions were examined using multivariable polytomous logistic regression analyses. Results: At the time of the survey, approximately one half of the patients (46%) were either within 1 year (24.1%) or between 1 and 5 years (22.0%) of treatment. More than one third of cancer survivors reported that they did not receive detailed communication about follow-up care, and more than one half reported that they did not receive detailed communication regarding late or long-term effects, lifestyle recommendations, or emotional and social needs. Only 24% reported high-quality communication for all four elements, indicating that the vast majority experienced suboptimal communication. In multivariable analysis, survivors reporting a high communication quality with providers included those who were within 1 year of treatment, between the ages of 18 and 64 years, non-Hispanic black or other ethnicity, and married. Conclusion: Study findings demonstrate gaps in the communication quality experienced by cancer survivors in the United States and help identify survivors for targeted interventions.
Management of Depression in Patients With Cancer: A Clinical Practice Guideline
Authors: Li Madeline , Kennedy Erin B. , Byrne Nelson , Gérin-Lajoie Caroline , Katz Mark R. , Keshavarz Homa , Sellick Scott , Green Esther 
Published: July 2016

Purpose:This report updates the Cancer Care Ontario Program in Evidence-Based Care guideline for the management of depression in adult patients with cancer. This guideline covers pharmacologic, psychological, and collaborative care interventions, with a focus on integrating practical management tools to assist clinicians in delivering appropriate treatments for depression in patients with cancer.Methods:Recommendations were developed by synthesizing information from extant guidelines and reviews and searching for randomized controlled trials from the date of database inception (1964 for MEDLINE and 1974 for EMBASE) to January 2015. Quality assessment of guidelines and systematic reviews were conducted by using the Appraisal of Guidelines for Research and Evaluation II (AGREE II), Assessment of Multiple Systematic Reviews (AMSTAR), and Cochrane Risk of Bias tools. Final recommendations were developed through a standardized Program in Evidence-Based Care multidisciplinary expert and knowledge user review process.Results:Two high-quality relevant clinical practice guidelines, eight pharmacologic trials, nine psychological trials, and eight collaborative care intervention trials composed the evidence base upon which the recommendations were developed. Eight specific recommendations were made to establish a standard of care for the management of depression in patients with cancer. The recommendations and practical management tools were reviewed as being well organized and helpful, although systemic barriers to implementation were identified.Conclusion:This updated guideline supports the previous general recommendation that patients with cancer who have depression may benefit from psychological and/or pharmacologic interventions, without evidence for the superiority of any specific treatment over another. New recommendations for a collaborative care model that incorporates a stepped care approach suggest that multidisciplinary mental health care restructuring may be required for optimal management of depression.
Electronic Release of Pathology and Radiology Results to Patients: Opinions and Experiences of Oncologists
Authors: Winget Marcy , Haji-Sheikhi Farnoosh , Brown-Johnson Cati , Rosenthal Eben L. , Sharp Christopher , Buyyounouski Mark K. , Asch Steven M. 
Published: July 2016

Purpose: There is an emerging standard to provide patients rapid electronic access to elements of their medical records. Although surveys of patients generally support it, this practice is controversial among oncologists, because few empiric data are available for scenarios of potentially life-threatening conditions like cancer. We report the views of oncologists about patient electronic access to radiology and pathology results that could potentially indicate disease progression. Methods: Four months before oncologists were surveyed, final results of radiology/pathology reports were routinely made available to patients online through a secure portal after a 7-day, hold to provide clinicians time to review and communicate results with the patients. Mixed methods were used to assess physician attitudes and experiences toward this change. Results: One hundred twenty-nine oncologists were surveyed, and 82 (64%) responded. A small majority (54%) responded that the release of reports was somewhat or very beneficial for patients who received normal radiology/pathology results before discussion with a physician, but 87% said it was somewhat or very harmful for patients to receive abnormal results before discussion. Forty-nine percent reported that release of reports had a somewhat or very negative impact on communication with their patients. Conclusion: Almost half of oncologists reported that sharing digital radiology and pathology records had a negative impact on their communication with patients. Patient surveys in similar cancer populations would complement the physician perspective. Efforts are needed to improve consensus among oncologists and patients on how to best communicate such results in a timely fashion.
A review of cultural competence training in UK mental health settings
Authors: Clegg Stephanie , Heywood-Everett Suzanne , Siddiqi Najma 
Published: July 2016

Background: Cultural competence is key to high-quality mental health care and is a required competency for professionals. However, there is little to guide practitioners on the content, format, implementation or effectiveness of cultural competence training. Aims: This review aimed to identify the evidence base for cultural competence training in UK mental health settings and to summarise definitions, theoretical models, contents and measures of effectiveness used in such training. Methods: A systematic search and narrative synthesis of the literature on cultural competence training was conducted. Results: A literature search generated seven articles that met the inclusion criteria, which reported five original studies. There were no randomised controlled trials. Only two studies described training that was underpinned by an explicit definition or model of cultural competence. Three studies reported service user involvement. Conclusions: There literature on cultural competence training in mental health settings in the UK is surprisingly limited. There is insufficient evidence on which to base recommendations for clinical practice. Research is required to develop theoretically informed cultural competence training and evaluate its effectiveness
Assessment of anxiety in advanced cancer patients: a mixed methods study
Authors: Veldhuisen Hanneke , Zweers Danielle , de Graaf Everlien , Teunissen Saskia 
Published: July 2016

Background: Anxiety is a risk for reduced quality of life in advanced cancer patients. However, it is an overlooked symptom without routine use of instruments to assess anxiety. Aim: To gain insight into the use of instruments by nurses to assess anxiety in advanced cancer patients and the rationale behind it. Methods: Data with regard to nurses' use of instruments were collected from medical records of 154 patients in three settings. Additionally, 12 nurses were interviewed. Findings: Four instruments were used to assess anxiety. The frequency of assessed anxiety differed among settings. The application of instruments guided patient care and improved communication. Lack of knowledge was the main reason not to use instruments. Conclusions: Application was influenced by patient and environmental factors, knowledge, attitudes and beliefs of nurses. Multifaceted strategies, leadership and education of nurses in the assessment and analysis of anxiety are needed to improve symptom management in advanced cancer patients.
A prospective study of patient-centred outcomes in the management of malignant pleural effusions
Authors: Walker Susan , Zubrinic Marijana , Massey Christine , Shargall Yaron , Bédard Eric , Darling Gail 
Published: July 2016

Background: In a patient population with a limited life expectancy, malignant pleural effusion can significantly impact quality of life (QoL). Different treatment options are available, each with its own effect on QoL. To date, satisfaction with treatment options has not been evaluated. Purpose: To evaluate QoL and satisfaction with treatment using patient-reported outcomes for four different treatment strategies. Design: A prospective, cohort study that compared four treatment options: indwelling pleural catheter (IPC); video assisted thoracic surgery (VATS) and IPC; chest tube and talc slurry; and VATS talc poudrage. Setting: A total of 104 participants were treated across four acute care teaching hospitals in a large Canadian city. Measurements: Patient-reported outcomes were assessed using functional assessment of chronic illness therapy–palliative (FACIT–PAL), London Chest Activity of Daily Living scale and FACIT–treatment satisfaction questionnaires. Results: No significant difference was identified between the four treatments based on patient-reported outcomes. VATS talc poudrage provided the most durable improvement. At the 6-week post-treatment time point, the highest patient satisfaction was noted in patients who received VATS and talc pleurodesis, lowest satisfaction in patients with chest tube and talc pleurodesis; however, the differences were not statistically significant (p=0.20). VATS and talc pleurodesis had the highest scores at 6 weeks for recommendation of treatment to others; however, the comparison with other treatment groups was not statistically significant (p=0.22). For FACIT-PAL, total scores when analysed as one group, there was a statistically significant increasing trend (indicating improvement) (p<0.0001). Breathlessness, measured using the London Chest Activity of Daily Living scale, indicated a statistically decreasing trend, suggesting an improvement (p=0.0003). There was no statistically significant difference in trends over time between the four treatment groups. Conclusions: While all treatment options addressed the patients' symptoms and relieved dyspnoea, an IPC offered effective treatment with minimal discomfort and time in hospital yet still high satisfaction.
Whiteflies Provide Honeydew to Camponotus ants Without Receiving Reciprocal Favor
Authors: De Jesus Raí Martins , Paes Junior Ramon , Do Carmo Gleicy , Mota Danilo , Gontijo Lessando Moreira , Oliveira Marco Antonio 
Published: July 2016

The notion that tending ants provide protection to honeydew-producing hemipterans is widely accepted. Nevertheless, there have been debates about whether or not this protection can always disrupt the biological control of hemipterans. Although various hemipteran species interact with tending ants, most studies have focused on the mutualism between ants and aphids. Woolly whitefly Aleurothrixus floccosus (Maskell) is an important pest of citrus whose nymphs are frequently tended by ants such as Camponotus. However, it is unknown whether or not ants in this genus can disrupt biological control of woolly whitefly by protecting this pest’s nymphs from natural enemies. We investigated the impact of Camponotus ants on the biological control of woolly whitefly in the field by excluding or allowing the access of ants to whitefly nymph colonies in different tangerine trees. Furthermore, in a laboratory study we also assessed the behavior of Camponotus ants in response to woolly whitefly’s common predator cues (visual and scent). In summary, this field-laboratory study suggests that there is no mutualism between tending Camponotus ants and the whitefly A. floccosus; rather it indicates commensalism as an alternative interaction. Interactions as this may provide more benefits for the host plant, whereby Camponotus ants can reduce sooty mold by removing honeydew from the leaves and favor pest biological control by leaving the whiteflies unprotected.
What is a drawing?
Authors: Ashwin Clive 
Published: July 2016

Abstract
Drawing, both as process and product, has proved notoriously resistant to definition. The current need for a reformulated definition is made more pressing by the postulation of ‘an expanded field of drawing’ comparable with a presumed expanded field of sculpture. This expanded field of drawing is characterized by a widespread dissolution of the traditional boundaries between categories such as drawing, writing, diagram and code. A revolution in art practice has been accompanied by a corresponding resurgence in analytical theory and critical context, reflected in exhibitions, publications and the formation of professional networks. In such a period of transformation and change it is advisable that we revisit the issue of definition of terms and practices. A variety of approaches to definition are reviewed, including ostensive and stipulative strategies. Wittgenstein’s concept of definition based upon ‘family resemblance’ is tested but found unhelpful in this case. The philosophical concepts of qualia and supervenience are introduced as useful strategies in formulating a consistent definition. The role of intention is appraised, as is the legitimacy of applying the concept of drawing by transference to print media. The article concludes with a proposal that there is still scope for a stipulative definition of drawing, and that the essence of drawing resides in the articulation of planar space. It is proposed that in this context the role of intention is immaterial. It is suggested that by deploying the concepts of qualia and supervenience the appellation ‘drawing’ can with some justification be extended by transference to a wide range of analogous products such as painting and prints.
Diamond turning fabrication of an ultra-compact endoscope
Authors: Huang Chih-Yu , Liang Rongguang 
Published: July 2016

Abstract
In this paper, we propose a technique by integrating mechanical mounts into lens elements to fulfill a self-aligned and self-assembled optical system. To prove this concept, we designed, fabricated, and tested an ultra-compact endoscope that adopts this technique. By taking advantages of the specially designed fixture and observing the interference fringes between the lens and fixture, we developed a method to minimize decenter and tilt between the two surfaces of the endoscope lens during the diamond turning fabrication process. The integrated mechanical mounts provide an easy assembly process for the endoscope system while maintaining high accuracy in system alignment. With the application of heat shrink tube as the endoscope system holder and to block stray light, the proposed endoscope system has the advantages of low cost, compact size, and high imaging quality.
Vaccination with a cocktail of Ancylostoma ceylanicum recombinant antigens leads to worm burden reduction in hamsters
Authors: Wiśniewski Marcin , Łapiński Maciej , Daniłowicz-Luebert Emilia , Jaros Sławomir , Długosz Ewa , Wędrychowicz Halina 
Published: July 2016

AbstractHookworms, a group to which
First report on the molecular characterization of Diaphorocleidus armillatus Jogunoori et al. 2004 (Monogenea: Dactylogyridae) infecting the gills of introduced fish, Gymnocorymbus ternetzi in India
Authors: Chaudhary Anshu , Verma Chandni , Singh Hridaya Shanker 
Published: July 2016

AbstractDuring an investigation of the diversity of monogenean parasites in Meerut, U.P., India, the exotic freshwater fish
Coasean Quality of Regulated Goods
Authors: Moszoro Marian W. 
Published: July 2016

Abstract
The quality of goods provided by public utilities depends on infrastructure features and operational inputs. I compare the economic efficiency that results from price ceilings and minimum quality standards (i. e., compliance with environmental, chemical, and performance standards and norms) imposed by a benevolent regulator to a Coasean bargaining solution between a median consumer and a monopolist. When quality is non-excludable and non-rival, rate-of-return regulation yields higher economic efficiency than price cap regulation.
Proximate biochemical composition and mineral content of edible species from the genus Cystoseira in Portugal
Authors: Vizetto-Duarte Catarina , Custódio Luísa , Barreira Luísa , Moreira da Silva Manuela , P. Rauter Amélia , Albericio Fernando , Varela João 
Published: July 2016

Abstract
Macroalgae are valuable resources for human consumption in many countries. This work reports for the first time a comparative evaluation of the nutritional properties of five edible macroalgae from the genus Cystoseira, namely C. humilis, C. tamariscifolia, C. nodicaulis, C. compressa and C. baccata. For this purpose, their proximate composition was determined in terms of moisture, ash, and total contents of protein, lipids, carbohydrates and mineral profile. Cystoseira tamariscifolia and C. baccata were the species that in general had the higher ash, protein and lipid contents, while the highest levels of moisture and total carbohydrates were detected in C. nodicaulis and C. compressa. Cystoseira species had also high amounts of minerals, especially of potassium, calcium and iron, and a favorable Na/K ratio. The present study shows that Cystoseira has a balanced nutritional composition, suitable for human consumption, and that its intake can contribute to a healthy and well-balanced diet.