bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary Concurrent Chemoradiation in Head and Neck Cancers with Weekly Cisplatin Chemotherapy: Analysis of Compliance, Toxicity and Survival
Authors: Iqbal Muhammad , Chaw Cheng , Kovarik Josef , Aslam Shahzeena , Jackson Aaron , Kelly John , Dobrowsky Werner , Kelly Charles 
Published: December 2016

Introduction Concurrent chemoradiation is the standard of care in inoperable locally advanced squamous cell head and neck cancers. The most widely accepted schedule of concomitant cisplatin is 100mg/m2 given on a 3 weekly basis but the optimal regime is unknown.
Objective The objective of this study is to assess the tolerability, compliance, and clinical outcomes of weekly cisplatin (40mg/m2).
Methods During the period of January 2007–December 2009, we analyzed retrospectively 122 patients with histologically proven squamous cell carcinoma of head and neck (nasopharynx, oropharynx, larynx, hypopharynx, and oral cavity) treated with definitive chemoradiation. All patients received 63 Gy in 30 daily fractions with concomitant weekly cisplatin 40mg/m2. We assessed treatment toxicities and patient compliance. We estimated overall survival using the Kaplan-Meier method.
Results Sixty-eight percent of patients managed to complete all six cycles of chemotherapy while 87% of patients completed at least 5 cycles of weekly cisplatin. Incidence of grade 3/4 toxicity was as follows: mucositis 33%, dermatitis 41%, dysphagia 15%, mouth/neck pain 17%, neutropenia 2%, and renal impairment 3%. 53% patients required at least one hospital admission for symptom control. The 5-year overall survival rate was 60%.
Conclusion Concurrent chemoradiotherapy using weekly cisplatin at 40mg/m2 per week is an effective, well tolerated regimen allowing most patients to receive at least 5 cycles of chemotherapy. However, a phase III randomized control trial comparing the standard dose of 100mg/m2 cisplatin tri-weekly with a weekly regimen is needed to establish the long term clinical outcome.
Investigating telemonitoring practice: a proposed work-applied methodology
Authors: Jurman Paul , Shafei Ingy 
Published: December 2016

PurposeDiabetes is regarded as a global epidemic with 382 million people globally suffering from diabetes. It also has major implications on patients’ quality of life. There are also high cost of treatment associated with diabetes for both patient and healthcare provider. Telemonitoring represents an excellent technology opportunity to redefine health care delivery. Using technology for home-based care promises the ability to deliver more cost effective care whilst also enhancing quality of care and patient satisfaction. The paper aims to discuss these issues.Design/methodology/approachThe current research aims to contribute to the methodological design of action research projects in their use to implementation health technologies such as telemonitoring. In particular, it seeks create a model which can be used to demonstrate the efficacy of the use of the action research method as a viable alternative to the traditional randomised control trials methodology currently employed in healthcare.FindingsThe paper contributes towards the methodological design to investigate the area of practice making use of the telemonitoring programme within a Victorian Health Services Network using action research.Originality/valueIt intends to address the research problem of the low utilisation of telemonitoring within Monash Health as a whole, and more specifically within the diabetes unit. In this context the research intends to utilise the benefits of telemonitoring to improve clinical outcomes of patients by increasing insulin stabilisation. It is also intended the research organisation benefits by increased efficiency by decreasing clinical workforce time spent on managing patient insulin data.
A radical agenda for enabling organisation transformation through work-applied learning
Authors: Critten Peter 
Published: December 2016

Purpose
The purpose of this paper is to challenge how we have traditionally thought about organisations and introduce two frameworks to enable us to understand how change in organisations might be facilitated better.

Design/methodology/approach
The paper discusses organisations as complex adaptive systems and uses complexity theory to inform two new frameworks for facilitating organisational learning and change.

Findings
In order for organisational learning to occur we need to change our mind-set of how we see organisations and to think of learning not just as individual but also as generative “communicative action” that emerge out of collaborative relationships.

Research limitations/implications
The frameworks proposed are grounded in organisational learning literature and the experience of the author. The proposed agenda for organisational learning has yet to be acted upon and evaluated.

Practical implications
The frameworks can be used to enhance understanding of learning and change in organisations. The agenda for enabling organisational transformation identifies key steps to put the ideas developed in the paper into practice.

Social implications
The approach advocated for use within organisations is one of empowerment and collaboration rather than top down direction.

Originality/value
The paper introduces new frameworks and a practical agenda to bring about organisational transformation through work-applied learning.
Reviving the ubuntu spirit in landscapes of practice: evidence from deep within the forest
Authors: Wall Tony 
Published: December 2016

Purpose
The purpose of this paper is to offer a humanistic perspective on practice and prompts us to think about some of the implications for a more connected perspective on work and learning.

Design/methodology/approach
This paper takes literary and metaphoric approach to discussion to evoke and engage the audience. It uses the primary device of the thriving of forests to prompt reflection.

Findings
This paper prioritises concepts of sustainability and responsibility and aims to prompt the reader in thinking about connectedness in relation to their own life and work.

Originality/value
This paper attempts to challenge an overly economic concept of work and learning, and offers an alternative humanistic metaphor to evoke and engage the reader. It values and encourages an experimental form of writing.
Factitious Disorder in a Patient Claiming to be a Sexually Sadistic Serial Killer
Authors: Fischer Christopher A. , Beckson Mace , Dietz Park 
Published: December 2016

AbstractFactitious disorder involves the conscious simulation of psychological or physiological symptoms of illness, for the purpose of fulfilling the unconscious desire to be taken care of or to assume the “sick role.” Typically patients with factitious disorder simulate conditions that are designed to arouse feelings of empathy in care providers with the intention to engage them in caretaking. However, patients might also simulate conditions that arouse revulsion or rejection and still meet full diagnostic criteria for factitious disorder. In this case report, we present a patient who fabricated an elaborate history of being a sexually sadistic serial killer with homicidal ideation with the intention of obtaining personal attention, nurturance, and empathy from his psychotherapist. However, given the nature of his feigned condition, the patient frightened the very person whom he sought to engage in caretaking.
Bioactive secondary metabolites with multiple activities from a fungal endophyte
Authors: Bogner Catherine W. , Kamdem Ramsay S.T. , Sichtermann Gisela , Matthäus Christian , Hölscher Dirk , Popp Jürgen , Proksch Peter , Grundler Florian M.W. , Schouten Alexander 
Published: December 2016

SummaryIn order to replace particularly biohazardous nematocides, there is a strong drive to finding natural product‐based alternatives with the aim of containing nematode pests in agriculture. The metabolites produced by the fungal endophyte Fusarium oxysporum 162 when cultivated on rice media were isolated and their structures elucidated. Eleven compounds were obtained, of which six were isolated from a Fusarium spp. for the first time. The three most potent nematode‐antagonistic compounds, 4‐hydroxybenzoic acid, indole‐3‐acetic acid (IAA) and gibepyrone D had LC50 values of 104, 117 and 134 μg ml−1, respectively, after 72 h. IAA is a well‐known phytohormone that plays a role in triggering plant resistance, thus suggesting a dual activity, either directly, by killing or compromising nematodes, or indirectly, by inducing defence mechanisms against pathogens (nematodes) in plants. Such compounds may serve as important leads in the development of novel, environmental friendly, nematocides.
Efficacy of anakinra in an adult patient with recurrent pericarditis and cardiac tamponade as initial manifestations of tumor necrosis factor receptor‐associated periodic syndrome due to the R92Q TNFRSF1A variant
Authors: Camprubí Daniel , Mitjavila Francesca , Arostegui Juan I. , Corbella Xavier 
Published: December 2016

AbstractTumor necrosis factor receptor‐associated periodic syndrome (TRAPS) is a dominantly inherited autoinflammatory disease caused by TNFRSF1A mutations. Patients with TRAPS suffer from recurrent, long episodes with fever, arthralgia/arthritis, migratory myalgias, abdominal pain, serositis, conjunctivitis and migratory erythematous skin rash. More than 70 different TNFRSF1A mutations have been reported to date, and as consequence of its genetic heterogeneity, TRAPS shows a variable phenotypic expression. Among TNFRSF1A variants, the low‐penetrance p.Arg92Gln variant represents the most commonly detected, and is typically associated with mild and short episodes, with a higher tendency to spontaneous resolution, and less familial association than the structural TNFRSF1A mutations. Pericardial involvement is rare but a well‐known clinical feature of TRAPS, with a significant increased rate in those adult patients in whom the onset of the disease occurred during adulthood. Moreover, idiopathic recurrent acute pericarditis has also been occasionally described as a clinical presentation of TRAPS. However, cardiac tamponade is an unusual initial manifestation of the disease. Herein, we present a brief review based on the description of the exceptional case of a 35‐year‐old female patient who presented with recurrent pericardial effusions and cardiac tamponade. TNFRSF1A analyses showed a heterozygous genotype for the low‐penetrance p.Arg92Gln variant. Due to disease severity, the patient was treated with the anti‐interleukin‐1 drug anakinra, showing a prompt resolution of her clinical manifestations.
The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood
Authors: Li James J. , Cho Seung Bin , Salvatore Jessica E. , Edenberg Howard J. , Agrawal Arpana , Chorlian David B. , Porjesz Bernice , Hesselbrock Victor ,   COGA Investigators, Dick Danielle M. 
Published: December 2016

BackgroundHeavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such as drug and alcohol dependence. Genetic and peer influences are robust predictors of heavy episodic drinking in youth, but little is known about the interplay between polygenic risk and peer influences as they impact developmental patterns of heavy episodic drinking.MethodsData were from a multisite prospective study of alcohol use among adolescents and young adults with genome‐wide association data (n = 412). Generalized linear mixed models were used to characterize the initial status and slopes of heavy episodic drinking between age 15 and 28. Polygenic risk scores (PRS) were derived from a separate genome‐wide association study for alcohol dependence and examined for their interaction with substance use among the adolescents’ closest friends in predicting the initial status and slopes of heavy episodic drinking.ResultsClose friend substance use was a robust predictor of adolescent heavy episodic drinking, even after controlling for parental knowledge and peer substance use in the school. PRS were predictive of the initial status and early patterns of heavy episodic drinking in males, but not in females. No interaction was detected between PRS and close friend substance use for heavy episodic drinking trajectories in either males or females.ConclusionsAlthough substance use among close friends and genetic influences play an important role in predicting heavy episodic drinking trajectories, particularly during the late adolescent to early adult years, we found no evidence of interaction between these influences after controlling for other social processes, such as parental knowledge and broader substance use among other peers outside of close friends. The use of longitudinal models and accounting for multiple social influences may be crucial for future studies focused on uncovering gene–environment interplay. Clinical implications are also discussed.
Establishment of in vitro model of erectile dysfunction for the study of high‐glucose‐induced angiopathy and neuropathy
Authors: Yin G. N. , Park S.‐H. , Song K.‐M. , Limanjaya A. , Ghatak K. , Minh N. N. , Ock J. , Ryu J.‐K. , Suh J.‐K. 
Published: December 2016

SummaryPenile erection requires complex interaction between vascular endothelial cells, smooth muscle cells, pericytes, and autonomic nerves. Diabetes mellitus is one of the most common causes of erectile dysfunction (ED) and multiple pathogenic factors, such as cavernous angiopathy and autonomic neuropathy, are associated with diabetic ED. Although a variety of animal models of diabetic ED play an important role in understanding pathophysiologic mechanisms of diabetes‐induced ED, these animal models have limitations for addressing the exact cellular or molecular mechanisms involved in ED. Therefore, we established an in vitro model of ED for the study of high‐glucose‐induced angiopathy and neuropathy. We successfully isolated and cultivated mouse cavernous endothelial cells (MCECs) and mouse cavernous pericytes (MCPs). The cells were exposed to the normal‐glucose (5 mmoL) or high‐glucose (30 mmoL) condition for 48 h. In vitro matrigel assay revealed impairments in tube formation in primary cultured MCECs or MCPs exposed to high‐glucose condition. To study cellular interaction between MCECs and MCPs, co‐culture systems including indirect contact, indirect non‐contact, and direct mixed co‐culture system, were established. We observed impaired tube formation and increased permeability in MCECs‐MCPs co‐culture exposed to high‐glucose condition. To evaluate the effect of high‐glucose on neurite sprouting, the mouse major pelvic ganglion (MPG) tissue was harvested and cultivated in matrigel. Neurite outgrowth and nNOS‐positive nerve fibers were significantly lower in MPG tissues exposed to the high‐glucose condition than in the tissues exposed to the normal‐glucose condition. We believe that in vitro model of ED will aid us to understand the role of each cellular component in the pathogenesis of diabetic ED, and also be a useful tool for determining the efficacy of candidate therapeutics targeting vascular or neuronal function. This model would present a new avenue for drug discovery and development of novel therapeutic modalities for erectile dysfunction.
The Fertility Assessment and Counseling Clinic – does the concept work? A prospective 2‐year follow‐up study of 519 women
Authors: Birch Petersen Kathrine , Maltesen Thomas , Forman Julie L. , Sylvest Randi , Pinborg Anja , Larsen Elisabeth C. , Macklon Kirsten T. , Nielsen Henriette S. , Hvidman Helene W. , Nyboe Andersen Anders 
Published: December 2016

AbstractIntroductionThe Fertility Assessment and Counseling (FAC) Clinic was initiated to provide women with information about their current fertility status to prevent infertility and smaller families than desired. The aim was to study the predictive value of a risk assessment score based on known fertility risk factors in terms of time to pregnancy.Material and methodsProspective cohort study of the first 570 women attending the FAC Clinic from 2011 to 2013 at Rigshospitalet, Denmark. A consultation included: risk assessment score sheet with items on infertility risk factors, anti‐Müllerian hormone and ultrasound. The risk score was categorized as low, medium or high. After 2 years an email‐based questionnaire was distributed regarding subsequent pregnancies.ResultsThe follow‐up questionnaire was answered by 519 women (91.1%). The mean age was 35 years and 38% were single at inclusion. The majority (67.8%, 352/519) tried to conceive within 2 years after attending the FAC Clinic. At follow up, 73.6% (259/352) had achieved a pregnancy, 21% (74/352) were still trying and 5.4% (19/352) had given up. Two‐thirds (65%) with only low risk scores conceived spontaneously within 12 months, although this figure was only 32% for women with at least one high risk score (n = 82). Accordingly, presence of at least one high risk score reduced the odds of achieving a pregnancy within 12 months by 75% (OR 0.25, 95% CI 0.12–0.52).ConclusionThe new FAC Clinic concept seems usable and offers a tool for fertility experts to guide women on how to fulfill their reproductive life‐plan.
Area‐based study shows most parents follow advice to reduce risk of sudden infant death syndrome
Authors: Strömberg Celind Frida , Wennergren Göran , Möllborg Per , Goksör Emma , Alm Bernt 
Published: December 2016

AbstractAimGuidance on reducing the risk of sudden infant death syndrome (SIDS) was successfully introduced to a number of countries in the early 1990s. The most important recommendations were supine sleeping for infants and non‐smoking for mothers. This 2012–2014 study examined adherence to the national Swedish SIDS advice.MethodsWe asked 1000 parents with infants registered at child healthcare centres in western Sweden to complete a questionnaire on infant care from birth to 12 months of age.ResultsWe analysed 710 responses and found that, in the first three months, 1.3% of the infants were placed in the prone sleeping position and 14.3% were placed on their side. By three to five months, this had risen to 5.6% and 23.6%. In the first three months, 83.1% were breastfed, 84.1% used a pacifier and 44.2% shared their parents' bed, while 5.8% slept in another room. Bed sharing was more likely if infants were breastfed and less likely if they used pacifiers. During pregnancy, 2.8% of the mothers smoked and the mothers who had smoked during pregnancy were less likely to bed share.ConclusionOverall adherence to the SIDS advice was good, but both prone and side sleeping practices should be targeted.
Are behaviour problems in extremely low‐birthweight children related to their motor ability?
Authors: Danks Marcella , Cherry Kate , Burns Yvonne R. , Gray Peter H. 
Published: December 2016

AbstractAimTo investigate whether behaviour problems are independently related to mild motor impairment in 11–13‐year‐old children born preterm with extremely low birthweight (ELBW).MethodsThe cross‐sectional study included 48 (27 males) non‐disabled, otherwise healthy ELBW children (<1000 g) and 55 (28 males) term‐born peers. Parents reported behaviour using the Child Behaviour Checklist (CBCL). Children completed the Movement Assessment Battery for Children (Movement ABC).ResultsExtremely low birthweight children had poorer behaviour scores (CBCL Total Problem T score: mean difference = 5.89, 95% confidence interval = 10.29, 1.49, p = 0.009) and Movement ABC Total Motor Impairment Scores (ELBW group median = 17.5, IQR = 12.3; term‐born group median = 7.5, IQR = 9, p < 0.01) than term‐born peers. Behaviour was related to motor score (regression coefficient 2.16; 95% confidence interval 0.34, 3.97, p = 0.02) independent of gender, socio‐economic factors or birthweight. Motor score had the strongest association with attention (ρ = 0.51; p < 0.01) and social behaviours (ρ = 0.50; p < 0.01).ConclusionBehaviour problems of otherwise healthy 11‐ to 13‐year‐old ELBW children are not related to prematurity independent of their motor difficulties. Supporting improved motor competence in ELBW preteen children may support improved behaviour, particularly attention and social behaviours.
Effectiveness of the repeated administration of scopolamine ointment on clozapine‐induced hypersalivation in patients with treatment‐resistant schizophrenia: A preliminary study
Authors: Takeuchi Ippei , Hanya Manako , Uno Junji , Fujita Kiyoshi , Kamei Hiroyuki 
Published: December 2016

AbstractIntroductionThis study investigated the efficacy of scopolamine (an anticholinergic agent) ointment against clozapine‐induced hypersalivation.MethodsThe patients enrolled in this study consisted of 10 clozapine‐treated schizophrenia patients and 10 healthy adult men. A prospective, randomized, double‐blind, crossover, placebo‐controlled clinical trial was designed.ResultsA total of 10 patients and 10 healthy adult men completed the study. No significant reduction in the saliva production of the clozapine‐treated patients was observed; however, that of the healthy adult men decreased significantly.DiscussionScopolamine ointment was not effective against clozapine‐induced hypersalivation. A further study is necessary for confirming its effect.
Molecular typing for blood group antigens within 40 min by direct polymerase chain reaction from plasma or serum
Authors: Wagner Franz F. , Flegel Willy A. , Bittner Rita , Döscher Andrea 
Published: December 2016

SummaryDetermining blood group antigens by serological methods may be unreliable in certain situations, such as in patients after chronic or massive transfusion. Red cell genotyping offers a complementary approach, but current methods may take much longer than conventional serological typing, limiting their utility in urgent situations. To narrow this gap, we devised a rapid method using direct polymerase chain reaction (PCR) amplification while avoiding the DNA extraction step. DNA was amplified by PCR directly from plasma or serum of blood donors followed by a melting curve analysis in a capillary rapid‐cycle PCR assay. We evaluated the single nucleotide polymorphisms underlying the clinically relevant Fya, Fyb, Jka and Jkb antigens, with our analysis being completed within 40 min of receiving a plasma or serum sample. The positive predictive value was 100% and the negative predictive value at least 84%. Direct PCR with melting point analysis allowed faster red cell genotyping to predict blood group antigens than any previous molecular method. Our assay may be used as a screening tool with subsequent confirmatory testing, within the limitations of the false‐negative rate. With fast turnaround times, the rapid‐cycle PCR assay may eventually be developed and applied to red cell genotyping in the hospital setting.