bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensional synthesis of a 3U

P

S-

P

RU parallel robot
Authors: Zhao Yongjie , Cheng Gang 
Published: January 2017

SUMMARYThis paper introduces the methodology of the dimensional synthesis for a 3UPS-PRU parallel robot. The dimensional synthesis of the 3UPS-PRU parallel robot is proposed considering the maximum input velocity of actuating joints as the objective function and constraints on the installation dimension, robot dimension, joint rotation angle and interference. The objective of the dimensional synthesis is to minimize the maximum input velocity of actuating joints when the moving platform translates along the z-axis in the maximum linear velocity and rotates about an arbitrary axis in the maximum angular velocity in the desired workspace. The constraint on the robot dimension is included in the dimensional synthesis of the 3UPS-PRU parallel robot when pursuing the kinematic property to meet the miniaturization principle with the reduced building cost. An example of the dimensional synthesis of a 3UPS-PRU parallel robot is presented with the maximum linear velocity and angular velocity required for the moving platform in the desired workspace.
The Demand for Systematicity and the Authority of Theoretical Reason in Kant
Authors: Mudd Sasha 
Published: January 2017

AbstractKant’s notoriously unclear attempt to defend the regulative principle of systematic unity as the supreme principle of theoretical reason in the Appendix to the Transcendental Dialectic has left its status a source of controversy. According to the dominant interpretation, the principle ought to be understood as a methodologically necessary device for extending our understanding of nature. I argue that this reading is flawed. While it may correctly affirm that the principle is normative in character, it wrongly implies that it binds with mere hypothetical necessity. I offer novel grounds for thinking that if reason’s principle is normative, then it binds agents categorically instead.
The ‘Two Experiments’ of Kant’s Religion: Dismantling the Conundrum
Authors: Pasternack Lawrence 
Published: January 2017

AbstractThe past decade has seen a sizeable increase in scholarship on Kant’s Religion. Yet, unlike the centuries of debate that inform our study of his other major works, scholarship on the Religion is still just in its infancy. As such, it is in a particularly vulnerable state where errors made now could hinder scholarship for decades to come. It is the purpose of this article to mitigate one such danger, a danger issuing from the widely assumed view that the Religion is shaped by ‘two experiments’. I will begin with a survey of the four current interpretations of the experiments, and then propose one further interpretation, one that hopefully will help dismantle this alleged ‘conundrum’ and thereby help scholarship on the Religion move beyond this early misstep.
Vitamin D Receptor Activator Use and Cause-specific Death among dialysis Patients: a Nationwide Cohort Study using Coarsened Exact Matching
Authors: Obi Yoshitsugu , Hamano Takayuki , Wada Atsushi , Tsubakihara Yoshiharu ,   The Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy, Nakai Shigeru , Hanafusa Norio , Masakane Ikuto , Itami Noritomo , Yamagata Kunihiro , Shinoda Toshio , Kazama Junichiro James , Watanabe Yuzo , Shigematsu Takashi , Marubayashi Seiji , Morita Osamu , Kimata Naoki , Wakai Kenji , Ogata Satoshi , Iseki Kunitoshi , Yamamoto Keiichi , Shintani Ayumu 
Published: January 2017

AbstractVitamin D receptor activators (VDRA) may exert pleiotropic effects on cardiovascular disease, malignancy, and infections among dialysis patients, but recent studies have mainly focused on cardiovascular outcomes. Among 8,675 patients who started dialysis in 2007 and who survived until January 1, 2010, listed in the Renal Data Registry of the Japanese Society for Dialysis Therapy, 5,365 VDRA users were matched to 3,203 non-users based on clinically relevant variables at the end of 2009 using the coarsened exact matching procedure. Until December 31, 2011, a total of 1,128 deaths occurred, of which 468 (42%) were cardiovascular deaths, 229 (20%) were infection-related deaths, and 141 (12%) were malignancy-related deaths. Multivariable survival analyses accounting for intra-region correlation revealed that VDRA use was significantly associated with lower rates of infection- and malignancy-related deaths [subhazard ratio 0.62 (95% CI, 0.52–0.73) and 0.70 (95% CI, 0.50–0.97), respectively] but not with cardiovascular death [subhazard ratio 0.86 (95% CI, 0.72–1.04)]. Future randomized clinical trials with a sufficient sample size and an adequate follow-up period are warranted to test the clinical effectiveness of VDRA on infection and malignancy, rather than cardiovascular disease, among dialysis patients.
A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant
Authors: Brette Fabien , Shiels Holly A. , Galli Gina L. J. , Cros Caroline , Incardona John P. , Scholz Nathaniel L. , Block Barbara A. 
Published: January 2017

AbstractThe Deepwater Horizon disaster drew global attention to the toxicity of crude oil and the potential for adverse health effects amongst marine life and spill responders in the northern Gulf of Mexico. The blowout released complex mixtures of polycyclic aromatic hydrocarbons (PAHs) into critical pelagic spawning habitats for tunas, billfishes, and other ecologically important top predators. Crude oil disrupts cardiac function and has been associated with heart malformations in developing fish. However, the precise identity of cardiotoxic PAHs, and the mechanisms underlying contractile dysfunction are not known. Here we show that phenanthrene, a PAH with a benzene 3-ring structure, is the key moiety disrupting the physiology of heart muscle cells. Phenanthrene is a ubiquitous pollutant in water and air, and the cellular targets for this compound are highly conserved across vertebrates. Our findings therefore suggest that phenanthrene may be a major worldwide cause of vertebrate cardiac dysfunction.
Long Blood Residence and Large Tumor Uptake of Ruthenium Sulfide Nanoclusters for Highly Efficient Cancer Photothermal Therapy
Authors: Lu Zhuoxuan , Huang Feng-ying , Cao Rong , Zhang Liming , Tan Guang-hong , He Nongyue , Huang Jie , Wang Guizhen , Zhang Zhijun 
Published: January 2017

AbstractTransition metal sulfide (TMS) holds great potential in cancer photothermal therapy (PTT) because of the high absorbance in the near-infrared (NIR) region. The short blood circulation time and limited tumor accumulation of TMS-based photothermal agents, however, limit their applications. Herein, we design a novel TMS-based PTT agent, ruthenium sulfide-based nanoclusters (NCs), to overcome the current limitations. We firstly develop a simple method to prepare oleic acid coated ruthenium sulfide nanodots (OA-RuS1.7 NDs) and assemble them into water-soluble NCs via sequentially coating with denatured bovine serum albumin (dBSA) and poly(ethylene glycol) (PEG). The obtained PEG-dBSA-RuS1.7 NCs possess excellent photothermal conversion ability. More significantly, they exhibit enhanced blood circulation time and tumor-targeting efficiency in vivo compared with other TMS-based PTT nanoagents, which may be attributed to their appropriate hydrodynamic diameter (~70 nm) and an ideal charge (~0 mV). These characteristics help the PEG-dBSA-RuS1.7 NCs to escape the removal by the reticuloendothelial system (RES) and kidney. All these advantages enable the PEG-dBSA-RuS1.7 NCs to selectively concentrate in tumor sites and effectively ablate the cancer cells upon NIR irradiation.
The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores
Authors: Willhoft Oliver , Kerr Richard , Patel Dipali , Zhang Wenjuan , Al-Jassar Caezar , Daviter Tina , Millson Stefan H. , Thalassinos Konstantinos , Vaughan Cara K. 
Published: January 2017

AbstractThe essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with Skp1, a small protein that heterodimerizes with proteins containing the F-box motif. We have determined the crystal structure of the interacting domains of Saccharomyces cerevisiae Sgt1 and Skp1 at 2.8 Å resolution and validated the interface in the context of the full-length proteins in solution. The BTB/POZ domain of Skp1 associates with Sgt1 via the concave surface of its TPR domain using residues that are conserved in humans. Dimerization of yeast Sgt1 occurs via an insertion that is absent from monomeric human Sgt1. We identify point mutations that disrupt dimerization and Skp1 binding in vitro and find that the interaction with Skp1 is an essential function of Sgt1 in yeast. Our data provide a structural rationale for understanding the phenotypes of temperature-sensitive Sgt1 mutants and for linking Skp1-associated proteins to Hsp90-dependent pathways.
Identification of miRNA, lncRNA and mRNA-associated ceRNA networks and potential biomarker for MELAS with mitochondrial DNA A3243G mutation
Authors: Wang Wei , Zhuang Qianqian , Ji Kunqian , Wen Bing , Lin Pengfei , Zhao Yuying , Li Wei , Yan Chuanzhu 
Published: January 2017

AbstractResearchers in the field of mitochondrial biology are increasingly unveiling of the complex mechanisms between mitochondrial dysfunction and noncoding RNAs (ncRNAs). However, roles of ncRNAs underlying mitochondrial myopathy remain unexplored. The aim of this study was to elucidate the regulating networks of dysregulated ncRNAs in Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) with mitochondrial DNA (mtDNA) A3243G mutation, which might make contributions to the unveiling of the complex mechanisms underlying mitochondrial myopathy and, possibly, new tools applicable to clinical practice. Through high-throughput technology followed by quantitative real-time polymerase chain reaction (qRT-PCR) and bioinformatics analyses, for the first time, we found that the dysregulated muscle miRNAs and lncRNAs between 20 MELAS patients with mtDNA A3243G mutation and 20 controls formed complex regulation networks and participated in immune system, signal transduction, translation, muscle contraction and other pathways in discovery and training phase. Then, selected ncRNAs were validated in muscle and serum in independent validation cohorts by qRT-PCR. Finally, ROC curve analysis indicated reduced serum miR-27b-3p had the better diagnosis value than lactate and might serve as a novel, noninvasive biomarker for MELAS. Follow-up investigation is warranted to better understand roles of ncRNAs in mitochondrial myopathy pathogenesis.
Germline large genomic alterations on 7q in patients with multiple primary cancers
Authors: Villacis R. A. R. , Basso T. R. , Canto L. M. , Nóbrega A. F. , Achatz M. I. , Rogatto S. R. 
Published: January 2017

AbstractPatients with multiple primary cancers (MPCs) are suspected to have a hereditary cancer syndrome. However, only a small proportion may be explained by mutations in high-penetrance genes. We investigate two unrelated MPC patients that met Hereditary Breast and Ovaria Cancer criteria, both presenting triple negative breast tumors and no mutations in BRCA1, BRCA2 and TP53 genes. Germline rearrangements on chromosome 7q, involving over 40 Mb of the same region, were found in both patients: one with mosaic loss (80% of cells) and the other with cnLOH (copy-neutral loss of heterozygosity) secondary to maternal allele duplication. Five children tested had no alterations on 7q. The patients shared 330 genes in common on 7q22.1-q34, including several tumor suppressor genes (TSGs) previously related to breast cancer risk and imprinted genes. The analysis of the triple negative BC from one patient revealed a mosaic gain of 7q translated for over-expressed cancer-related genes. The involvement of TSGs and imprinted genes, mapped on 7q, has the potential of being associated to MPC risk, as well as cancer progression. To our knowledge, this is the first description of patients with MPCs that harbor constitutive large alterations on 7q.
Synchrotron-based X-ray fluorescence microscopy enables multiscale spatial visualization of ions involved in fungal lignocellulose deconstruction
Authors: Kirker Grant , Zelinka Sam , Gleber Sophie-Charlotte , Vine David , Finney Lydia , Chen Si , Hong Young Pyo , Uyarte Omar , Vogt Stefan , Jellison Jody , Goodell Barry , Jakes Joseph E. 
Published: January 2017

AbstractThe role of ions in the fungal decay process of lignocellulose biomaterials, and more broadly fungal metabolism, has implications for diverse research disciplines ranging from plant pathology and forest ecology, to carbon sequestration. Despite the importance of ions in fungal decay mechanisms, the spatial distribution and quantification of ions in lignocellulosic cell walls and fungal hyphae during decay is not known. Here we employ synchrotron-based X-ray fluorescence microscopy (XFM) to map and quantify physiologically relevant ions, such as K, Ca, Mn, Fe, and Zn, in wood being decayed by the model brown rot fungus Serpula lacrymans. Two-dimensional XFM maps were obtained to study the ion spatial distributions from mm to submicron length scales in wood, fungal hyphae with the dried extracellular matrix (ECM) from the fungus, and Ca oxalate crystals. Three-dimensional ion volume reconstructions were also acquired of wood cell walls and hyphae with ECM. Results show that the fungus actively transports some ions, such as Fe, into the wood and controls the distribution of ions at both the bulk wood and cell wall length scales. These measurements provide new insights into the movement of ions during decay and illustrate how synchrotron-based XFM is uniquely suited study these ions.
Photodetector based on Vernier-Enhanced Fabry-Perot Interferometers with a Photo-Thermal Coating
Authors: Chen George Y. , Wu Xuan , Liu Xiaokong , Lancaster David G. , Monro Tanya M. , Xu Haolan 
Published: January 2017

AbstractWe present a new type of fiber-coupled photodetector with a thermal-based optical sensor head, which enables it to operate even in the presence of strong electro-magnetic interference and in electrically sensitive environments. The optical sensor head consists of three cascaded Fabry-Perot interferometers. The end-face surface is coated with copper-oxide micro-particles embedded in hydrogel, which is a new photo-thermal coating that can be readily coated on many different surfaces. Under irradiation, photons are absorbed by the photo-thermal coating, and are converted into heat, changing the optical path length of the probing light and induces a resonant wavelength shift. For white-light irradiation, the photodetector exhibits a power sensitivity of 760 pm/mW, a power detection limit of 16.4 μW (i.e. specific detectivity of 2.2 × 105 cm.√Hz/W), and an optical damage threshold of ~100 mW or ~800 mW/cm2. The response and recovery times are 3.0 s (~90% of change within 100 ms) and 16.0 s respectively.
A Quality Improvement Initiative to Reduce the Need for Mechanical Ventilation in Extremely Low Gestational Age Neonates
Authors: Templin Ludivine , Grosse Camille , Andres Virginie , Robert Clotilde , Fayol Laurence , Simeoni Umberto , Boubred Farid 
Published: January 2017

Objective Limiting early intubation and mechanical ventilation in extremely low gestational age neonates (ELGAN) may decrease neonatal morbidity and mortality. The aim of our study was to demonstrate the feasibility, efficacy, and tolerability of a delivery room respiratory management protocol, including delayed umbilical cord clamping (DUCC) in combination with optimized nCPAP with high PEEP levels and less invasive surfactant administration (LISA).
Study Design This cohort quality improvement study analyzed the respiratory and neonatal outcomes of all consecutive infants born between 24+0 and 26+6 weeks' gestation before (period 1, n = 40) and after (period 2, n = 52) implementing the new protocol.
Results Compared with the period 1 infants, the period 2 infants had a lower rate of intubation in the delivery room (31 vs. 90%, p = 0.001) and were less likely to need mechanical ventilation on day 3 (28 vs. 62%, p = 0.002) and during the hospital stay (75 vs. 92.5%, p < 0.05). The two groups did not differ in terms of mortality or neonatal morbidity.
Conclusion A delivery room respiratory management protocol based on DUCC, optimized nCPAP with high PEEP levels, and LISA procedure is both feasible and safe, and improved ELGAN respiratory outcomes.
“Imagine” – Participative strategies of two online minorities within Italian context
Authors: D’Errico Francesca 
Published: January 2017

Abstract
Within the field of political psychology studies, the main goal of the present study is to investigate in depth the role played by two different forms – E-Tactics vs E-Movement – of social media activism on the quality of discourses and their possible level of acquired empowerment. Two Italian cases of e-minorities (Teatro Valle Occupato and Roars) will be analysed in terms of argumentative moves following a pragma-dialectic perspective in order to observe how they can construct a possible process of conscientization. Results, achieved by means of quanti-qualitative methods, highlight how E-Tactics (Teatro Valle Occupato), differently from E-Movement (Roars), can better promote normative but also creative forms of argumentations, as activists can claim for their rights but mainly also promote value change. This type of activism is strongly correlated to political participation, differently from E-Movement, mainly oriented to individual empowerment.
Name as a regional brand
Authors: Semian Michal , Chromý Pavel , Kučera Zdeněk 
Published: January 2017

AbstractThe article addresses denominations of specific regions, Local Action Groups (LAGs), in Czechia, and contributes to the academic debate regarding: relationships between formation of regions, their symbolic shape and regional identity; formation of regions by means of regional development. A set of 179 LAG names registered in the database of the National Network of Local Action Groups in the Czech Republic as of March 2014 are examined. LAG names are first analyzed in terms of the phenomena that constitute their essence, and subsequently their territorial differentiation is discussed. The analysis affirms the importance of territorial approach towards regional denomination. It has equally been affirmed that region naming strategies are spatially fragmented. Nevertheless, the territorial differentiation of names of LAG regions mirrors the elementary spatial patterns traditionally reproduced in the Czech context, namely west-east gradient of development level, distinctions between historical lands and differences between inland and borderland resettled after WWII.
A Case Study of Genecol‐99: Possible Implications for Other Single‐Use Agricultural Biotechnology Products
Authors: Walsh Marie E. , Sundquist W. Burt 
Published: January 2017

AbstractGenecol‐99 is one of the first agricultural biotechnology products available commercially. Analysis of the potential market for this product may yield insights into the potential markets of future agricultural biotechnology products, which, like Genecol‐99, have single or very few uses and may only be used on specific species. In addition, analysis of returns on investment were made. This analysis suggests that marketing costs may be as significant as research and development costs.
Effects of varying laser trimming geometries on thin film resistors
Authors: Alafogianni Maria , Birkett Martin , Penlington Roger 
Published: January 2017

Purpose
This paper aims to study the effects of varying laser trim patterns on several performance parameters of thin film resistors such as the temperature coefficient of resistance (TCR) and target resistance value.

Design/methodology/approach
The benefits and limitations of basic trim patterns are taken into consideration, and the plunge cut, double plunge cut and the curved L-cut were selected to be modelled and tested experimentally. A computer simulation of the laser trim patterns has been developed for the modelling process of the resistors. The influence of the trim length and resistor dimensions on the TCR performance and resistance value of the resistors is investigated.

Findings
It is found that variation in trim length, within the range of 5 to 15 mm, can give significant increases in the TCR of the thin films. Thus, for the plunge cut, TCR can reach up to 11.51 ppm/oC, for the double plunge cut up to 14.34 ppm/oC and for the curved L-cut up to 5.11 ppm/oC.

Originality/value
Research on the effects of various laser trimming geometries on the TCR and target resistance accuracy is limited, especially for patterns such as the curved L-cut, which is investigated in this paper.
Asians’ Facial Responsiveness to Basic Tastes by Automated Facial Expression Analysis System
Authors: Zhi Ruicong , Cao Lianyu , Cao Gang 
Published: January 2017

AbstractGrowing evidence shows that consumer choices in real life are mostly driven by unconscious mechanisms rather than conscious. The unconscious process could be measured by behavioral measurements. This study aims to apply automatic facial expression analysis technique for consumers’ emotion representation, and explore the relationships between sensory perception and facial responses. Basic taste solutions (sourness, sweetness, bitterness, umami, and saltiness) with 6 levels plus water were used, which could cover most of the tastes found in food and drink.The other contribution of this study is to analyze the characteristics of facial expressions and correlation between facial expressions and perceptive hedonic liking for Asian consumers. Up until now, the facial expression application researches only reported for western consumers, while few related researches investigated the facial responses during food consuming for Asian consumers. Experimental results indicated that facial expressions could identify different stimuli with various concentrations and different hedonic levels. The perceived liking increased at lower concentrations and decreased at higher concentrations, while samples with medium concentrations were perceived as the most pleasant except sweetness and bitterness. High correlations were founded between perceived intensities of bitterness, umami, saltiness, and facial reactions of disgust and fear. Facial expression disgust and anger could characterize emotion “dislike,” and happiness could characterize emotion “like,” while neutral could represent “neither like nor dislike.” The identified facial expressions agree with the perceived sensory emotions elicited by basic taste solutions. The correlation analysis between hedonic levels and facial expression intensities obtained in this study are in accordance with that discussed for western consumers.