bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient control of high-precision three-dimensional atom localization via probe absorption in a five-level phase-coherent atomic system
Authors: Banerjee Aniket , Panchadhyayee Pradipta , Kumar Dutta Bibhas 
Published: September 2024

Abstract
We propose a new scheme for high-precision three-dimensional (3D) atom localization by observing the spatially modulated absorption of a weak probe field operating in a partially closed-loop dependent five-level atomic system. Different spatial structures of localization patterns are presented by controlling the Rabi frequency, detuning, and field-induced collective phase-coherence with a variety of superposed standing wave field configurations. Our results highlight that 100% detection probability of atom is possible in the present model in many ways with high precision measurement of spatial absorption. It has been shown that, in the presence of standing wave fields, position information of the atom with maximum detection probability can be efficiently controlled by employing the travelling-wave field in the system. In the present work, we note that the maximum detection probability of the atom is attainable with the limit of spatial resolution better than λ/50. The efficacy of the present model is to find its application in atom nanolithography and atom-imaging having importance in quantum information processing.
Weighing massive neutrinos with Lyman-α observations
Authors: Sarkar Anjan Kumar , Sethi Shiv K. 
Published: September 2024

AbstractThe presence of massive neutrinos has still not been revealed by the cosmological data. We consider a novel method based on the two-point line-of-sight correlation function of high-resolution Lyman-αdata to achieve this end in the paper. We adopt semi-analytic models of Lyman-αclouds for the study. We employ Fisher matrix technique to show that it is possible to achieve a scenario in which the covariance of the two-point function nearly vanishes for both the spectroscopic noise and the signal. We analyze this near `zero noise' outcome in detail to argue it might be possible to detect neutrinos of mass rangemν≃ 0.05–0.1 eV with signal-to-noise of unity with a single QSO line of sight. We show that this estimate can be improved to SNR ≃ 3–6 with data along multiple line of sights within the redshift rangez≃ 2–2.5. Such data sets already exist in the literature. We further carry out principal component analysis of the Fisher matrix to study the degeneracies of the neutrino mass with other parameters. We show that Planck priors lift the degeneracies between the neutrino mass and other cosmological parameters. However, the prospects of the detection of neutrino mass are driven by the poorly-determined parameters characterizing the ionization and thermal state of Lyman-αclouds. We have also mentioned the possible limitations and observational challenges posed in measuring the neutrino mass using our method.
Bondi-Hoyle-Lyttleton accretion around the rotating hairy Horndeski black hole
Authors: Dönmez O. 
Published: September 2024

Abstract
Modeling of the shock cone formed around a stationary, hairy Horndeski black hole with
Bondi-Hoyle-Lyttleton (BHL) accretion has been conducted. We model the dynamical changes of the
shock cone resulting from the interaction of matter with the Horndeski black hole, where the
scalar field and spacetime have a strong interaction. The effects of the scalar hair, the black
hole rotation parameter, and the impacts of the asymptotic speed have been examined, revealing the
influence of these parameters on the shock cone and the trapped QPO modes within the
cone. Numerical calculations have shown that the hair parameter significantly affects the
formation of the shock cone. As the absolute value of the hair parameter increases, the matter in
the region of the shock cone is observed to move away from the black hole horizon. The rate of
matter expulsion increases as h/M changes. After h/M < -0.6, a visible change in the physical
structure of the shock cone occurs, ultimately leading to the complete removal out of the shock
cone. On the other hand, it has been revealed that the asymptotic speed significantly affects the
formation of the shock cone. As h/M increases in the negative direction and the asymptotic speed
increases, the stagnation point moves closer to the black hole horizon. When the value of the hair
parameter changes, the rest-mass density of the matter inside the cone decreases, whereas the
opposite is observed with the asymptotic speed. Additionally, the formed shock cone has excited
QPO modes. The deformation of the cone due to the hair parameter has led to a change or complete
disappearance of the QPOs. Meanwhile, at asymptotic speeds of V
∞/c < 0.4, all
fundamental frequency modes are formed, while at V
∞/c = 0.4, only the azimuthal mode is
excited, and 1:2:3:4:… resonance conditions occur. No QPOs have formed at V
∞/c =
0.6. The results obtained from numerical calculations have been compared with theoretical
studies for M87*, and it has been observed that the possible values of h/M found in the
numerical simulations are consistent with the theory. Additionally, the results have been compared
with those for the GRS 1915+105 black hole, and the hair parameters corresponding to the observed
frequencies have been determined.
Effect of evanescent wave on vector vortex beams on higher-order Poincaré sphere
Authors: Jia Xinting , Jia Jing 
Published: September 2024

Abstract
Based on the vector angular spectrum representation, the contributions of the propagating and evanescent waves to the vector vortex Laguerre–Gaussian beams on the higher-order Poincaré sphere are investigated in the nonparaxial regime. The evolution properties of the propagating and evanescent waves are closely related to the topological charge, the radial order, the ellipticity angle, and the waist width. The influences of the evanescent waves on the intensity, the spin and orbital angular momenta of the vector vortex beams are discussed in detail.
Determination of the discreteness correction in dislocation equations for sphalerite crystals
Authors: Zhang Huili , Lu Defang , Li Yanyan 
Published: September 2024

Abstract
The discreteness correction for simple lattices has been determined, however, there is still no detailed and rigorous derivation of the discreteness correction for compound lattices due to the relatively complex structure (simple lattices have only one set per slip system, while complex lattices have at least two sets). A lattice dynamics model which takes into account the energy increments caused by changes in bond length and bond angle is constructed for sphalerite crystals and the relationships between discreteness parameters and elastic constants are determined for the

110

111

slip system. Compared to glide set, the discreteness correction for shuffle set is much larger due to it is mainly contributed by the interactions between nearest neighbor atoms. Based on the results obtained from the model, the dislocations in ZnS crystal are investigated. The theoretical prediction result of Peierls stress for shuffle

60
°

dislocation closely matches the experimental critical shear stress. It is inferred that the initial plastic deformation of ZnS is closely related to the movement of shuffle

60
°

dislocations.
Effects of different corrugated rolls on the performance of BTW1/Q345R composite plate
Authors: Liu Pengtao , Wang Ke , Zhi Chenchen , Zhao Guanghui , Ma Lifeng , Gao Xiangyu , Li Aifeng , Ma Lianwei 
Published: September 2024

Abstract
BTW1/Q345R composite plate not only has the advantages of high strength and high wear resistance, but also helps to reduce energy consumption and production cost. This paper proposes a novel rolling process based on corrugated rolls for the preparation of wear-resistant steel BTW1/Q345R composite plates. In order to analyze and study the microstructure, and mechanical properties of BTW1/Q345R composite plates after rolling, techniques such as electron backscatter diffraction (EBSD) were used. The results indicate that the composite plate obtained through rolling with the corrugated roll of 72 cycles (3# corrugated roll) exhibits a yield strength of 550 MPa, tensile strength of 705 MPa, elongation at break of 17.57%, and shear strength of the composite interface at 242 MPa. Notably, the rolling process with a 3# corrugated roll yields the best combination of tensile mechanical performance and interface bonding performance for the composite plate.
Encapsulation of human natural killer cells into novel gelatin-based polymeric hydrogel networks
Authors: Cendere Sibel , Yuksel Ceren , Ovali Ercument , Kinikoglu Beste , gok ozgul 
Published: September 2024

Abstract
In the innate immune system, natural killer (NK) cells are effector lymphocytes which control several tumor types and microbial infections by limiting disease spread and tissue damage. With tumor cell killing abilities, with no priming or prior activation, NKs are potential anti-cancer therapies. In clinical practice, NKs are used in intravenous injections as they typically grow as suspension, similar to other blood cells. In this study, we designed a novel and effective biomaterial-based platform for NK cell delivery, which included in-situ NK cell encapsulation into three-dimensional (3D) biocompatible polymeric scaffolds for potential anti-cancer treatments. Depending on physical cross-linking between an alginate (ALG) polymer and a divalent cation, two natural polymers (gelatin (GEL) and hyaluronic acid (HA)) penetrated into pores and generated an inter-penetrating hydrogel system with improved mechanical properties and stability. After extensive characterization of hydrogels, NK cells were encapsulated inside using our in-situ gelation procedure to provide a biomimetic microenvironment.&#xD;
Bridged Treatment Comparisons: an Illustrative Application in HIV Treatment
Authors: Zivich Paul N , Cole Stephen R , Edwards Jessie K , Shook-Sa Bonnie E , Breskin Alexander , Hudgens Michael G 
Published: September 2024

Abstract
Comparisons of treatments, interventions, or exposures are of central interest in epidemiology, but direct comparisons are not always possible due to practical or ethical reasons. Here, we detail a fusion approach to compare treatments across studies. The motivating example entails comparing the risk of the composite outcome of death, AIDS, or greater than a 50% CD4 cell count decline in people with HIV when assigned triple versus mono antiretroviral therapy, using data from the AIDS Clinical Trial Group (ACTG) 175 (mono versus dual therapy) and ACTG 320 (dual versus triple therapy). We review a set of identification assumptions and estimate the risk difference using an inverse probability weighting estimator that leverages the shared trial arms (dual therapy). A fusion diagnostic based on comparing the shared arms is proposed that may indicate violation of the identification assumptions. Application of the data fusion estimator and diagnostic to the ACTG trials indicates triple therapy results in a reduction in risk compared to monotherapy in individuals with baseline CD4 counts between 50 and 300 cells/mm3. Bridged treatment comparisons address questions that none of the constituent data sources could address alone, but valid fusion-based inference requires careful consideration of the underlying assumptions.
BRD3308 suppresses macrophage oxidative stress and pyroptosis via upregulating acetylation of H3K27 in sepsis-induced acute lung injury
Authors: Liu Bohao , Li Ning , Liu Yi , Zhang Yan , Qu Limei , Cai Hongfei , Li Yang , Wu Xiaojing , Geng Qing 
Published: September 2024

Abstract

Background
Sepsis-induced acute lung injury (ALI) leads to severe hypoxemia and respiratory failure, contributing to poor prognosis in septic patients. Endotoxin dissemination triggers oxidative stress and the release of inflammatory cytokines in macrophages, initiating diffuse alveolar damage. The role of epigenetic histone modifications in organ injury is increasingly recognized. The present study aimed to investigate the use of a histone modification inhibitor to alleviate sepsis-induced ALI, revealing a new strategy for improving sepsis patient survival.

Methods
In vivo models of ALI were established through the intraperitoneal injection of lipopolysaccharide and cecal ligation and puncture surgery. Furthermore, the disease process was simulated in vitro by stimulating Tamm-Horsfall protein-1 (THP-1) cells with lipopolysaccharide. Hematoxylin and eosin staining, blood gas analysis and pulmonary function tests were utilized to assess the extent of lung tissue damage. Western blot analysis, real-time polymerase chain reaction, enzyme-linked immunosorbent assay and immunofluorescence were used to measure the levels and distribution of the indicated indicators within cells and tissues. Reactive oxygen species and autophagic flux alterations were detected using specific probes.

Results
BRD3308, which is a inhibitor of histone deacetylase 3, improved lung tissue damage, inflammatory infiltration and edema in ALI by inhibiting Nod-like receptor protein3-mediated pyroptosis in macrophages. By upregulating autophagy, BRD3308 improved the disruption of redox balance in macrophages and reduced the accumulation of reactive oxygen species. Mechanistically, BRD3308 inhibited histone deacetylase 3 activity by binding to it and altering its conformation. Following histone deacetylase 3 inhibition, acetylation of H3K27 was significantly increased. Moreover, the increase in H3K27Ac led to the upregulation of autophagy-related gene 5, a key component of autophagosomes, thereby activating autophagy.

Conclusions
BRD3308 inhibits oxidative stress and pyroptosis in macrophages by modulating histone acetylation, thereby preventing sepsis-induced ALI. The present study provides a potential strategy and theoretical basis for the clinical treatment of sepsis-induced ALI.
Reshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing
Authors: Ding Xiaotong , Yang Chenxi , Li Yue , He Tangtang , Xu Yan , Cheng Xuxi , Song Jinyun , Xue Nannan , Min Wen , Feng Weimeng , Zhao Hongyu , Dong Jie , Liu Pei , Wang Yiwei , Chen Jun 
Published: September 2024

Abstract

Background
Calvatia gigantea (CG) is widely used as a traditional Chinese medicine for wound treatment. In this study, we aimed to determine the effects of CG extract (CGE) on diabetic wound healing and the commensal wound microbiome.

Method
A wound model was established using leptin receptor-deficient db/db mice, with untreated mice as the control group and CGE-treated mice as the treatment group. The wound healing rate, inflammation and histology were analyzed. Additionally, wound microbiome was evaluated via 16S ribosomal RNA (rRNA) gene sequencing.

Results
CGE significantly accelerated the healing of diabetic ulcer wounds, facilitated re-epithelialization, and downregulated the transcription levels of the inflammatory cytokines, interleukin-1β and tumor necrosis factor-α. Furthermore, CGE treatment positively affected the wound microbiome, promoting diversity of the microbial community and enrichment of Escherichia–Shigella bacteria in the CGE-treated group.

Conclusions
Overall, CGE enhanced diabetic wound healing by modulating the wound microbiome and facilitating macrophage polarization during inflammation. These findings suggest modulation of the commensal wound microbiome using medicinal plants as a potential therapeutic strategy for diabetic wounds.
199. YOUNGER AGE AS AN INDEPENDENT FACTOR FOR SUBSEQUENT HEAD AND NECK CANCER AFTER CURATIVE ESOPHAGECTOMY FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Authors: Tsai Ping-Chung , Tang En-Kuei 
Published: September 2024

Abstract

Background
Post-operative survival of esophageal cancer patients has improved with advances in technology and treatment modalities. However, squamous cell carcinoma often affects the esophagus together with the head and neck regions, with second primary head and neck cancer (SPHNC) adversely influencing the patients’ quality of life. Therefore, patients with esophageal squamous cell carcinoma (ESCC) should be carefully followed up post-operatively. This study evaluated the risk of developing SPHNCs after an esophagectomy for ESCC.

Methods
Patients with ESCC who underwent curative esophagectomy from January 2008 to December 2017 from two tertiary medical centers, Taipei Veteran General Hospital and Kaohsiung Veteran General Hospital, were retrospectively reviewed. SPHNC development was documented according to anatomic region and the cumulative incidence rate and risk factors were analyzed.

Results
The median observation time of the 435 patients included in our study was 48.5 months [interquartile range (IQR) 16.7–92.4 months]. Among the ESCC patients after curative esophagectomy, younger age &lt;50 [hazard ratio (HR) 4.13, 95% CI: 2.53–6.75, p &lt; 0.001) was the only independent factor for developing SPHNCs in the multivariable analysis. The cumulative incidence rate of SPHNCs of patients aged &lt; 50 years old was 14.3%, 22.1%, and 34.2% after 3, 5, and 10 years, respectively.

Conclusion
There was a high risk of secondary cancer after ESCC in the upper aerodigestive tract, especially the head and neck regions, therefore active surveillance is strongly recommended, especially in younger patients.
204. ALTERATIONS IN LOCAL OESOPHAGEAL MICROBIOTA AND OUTCOMES AFTER OESOPHAGECTOMY FOR OESOPHAGO-GASTRIC CANCER: A PILOT STUDY
Authors: Stokes Matthew , (Frank) Yu Zirong , Schlebusch Sanmarie , Jennison Amy , Graham Rikki , Cooper Caroline , Smithers B Mark , Barbour Andrew , Thomson Iain , Frankel Adam 
Published: September 2024

Abstract
Oesophageal cancer is a global health burden, with an estimated 600,000 new cases and 550,000 deaths per year. It is the 9th most common cancer yet is ranked fifth for cancer mortality. The current gold standard curative strategy includes oesophagectomy, which is a morbid procedure. In particular, anastomotic leaks are a feared complication postoperatively that result in significant morbidity.
Studies of patients undergoing colorectal cancer surgery show that alterations in the local microbiota can contribute to complications including anastomotic leak. Furthermore, some pathogenic bacterial species have been implicated in shorter recurrence-free survival periods after curative oncologic surgery.
Unlike bacterial culture, which requires viable bacteria to be preserved from the time of sampling through to processing, 16S RNA sequencing can be performed on both fresh and fixed tissues. However, there are few studies using either tissue source and to date, none that compare results from the same patient.
The aims of this pilot study were to:
1. Assess the feasibility of testing archived histological specimens (i.e. formalin fixed) that in turn facilitates retrospective analysis of patients with known clinical outcomes (i.e. anastomotic leaks)
2. Identify any difference (variance, reduce or over-abundance) between the microbiota of patients who suffered anastomotic leak and those who did not
3. Generate preliminary data to inform sample sizes, statistical methods, workflow and cost of a future prospective trial
Using an established Upper GI Cancer Surgery Database, we performed propensity score matching to identify 15 patients who had a clinically evident anastomotic leak to be matched with 15 patients who did not have an anastomotic leak. Known predictors of anastomotic leak (e.g. neoadjuvant radiotherapy, smoking status, COPD, chronic kidney disease, diabetes mellitus, chronic liver disease) have been controlled for.
Fresh frozen and formalin-fixed samples for the same patients were available. The formalin-fixed tissue was comprised of the "anastomotic doughnuts" created at the time of the circular stapled anastomosis. This tissue was chosen because of its immediate proximity to the anastomosis.
All samples were analysed using 16S RNA sequencing to obtain a full microbial profile. Sequencing data was analysed by scientific investigators blinded to the clinical outcome (i.e. anastomotic leak vs. no leak) using a pre-existing workflow and bioinformatics pipeline.
222. LONG-TERM SURVIVAL OF ROBOT-ASSISTED ESOPHAGECTOMY AND ITS UTILITY IN TREATING CT4B ESOPHAGEAL CANCER
Authors: Makino Tomoki , Momose Kota , Yamashita Kotaro , Tanaka Koji , Eguchi Hidetoshi , Doki Yuchiro 
Published: September 2024

Abstract

(Background)
Robot-assisted esophagectomy (RAMIE) has lately been introduced to many hospitals after its insurance approval. However, long-term outcome of RAMIE or its utility in treating cT3br-T4 esophageal cancer remains unclear.

(Methods)
A total of 188 esophageal cancer patients who underwent RAMIE between 2017 and 2022 were eligible in the present study. Among them, 20 cases with cT3br-T4 were reviewed to evaluate short-term outcome. Also, a comparison between RAMIE (n=66) and VATS (n=277) group with 2-year and longer follow-up time was made to evaluate their long-term outcomes.

(Results)
Background factors; age=71 (42-86), gender (M/F)= 145/43, tumor location (Ut/Mt/Lt, Ae)= 25/84/79, cT1/2/3/4= 36/31/101/20, cN0/1/2/3= 65/82/34/7, cM0/1= 155/33, and preoperative treatment (none/chemo/CRT/both)= 39/139/10. Surgical outcomes; operation time = 508 (273-833) min, console time=244 (108-479) min, estimated blood loss= 130 (0-2090) ml, overall postoperative morbidity (CD classification≧grade2) = 53.2% (pneumonia= 29.3%, atelectasis=9.0%, palsy of recurrent laryngeal nerve=10.1%, surgical site infection=5.9%, chylothorax=5.9%, and anastomotic leakage=5.9%). Postoperative hospital stay was 21 (12-385) days. The palsy rate of recurrent laryngeal nerve decreased from 9.1 to 0.7% after introducing intraoperative continuous nerve monitoring (NIM). In terms of RAMIE for cT3br-T4 cases (n=20), no convert to open or intraoperative complications were observed while all cases achieved R0 resection. Regarding survival comparison between the RAMIE (n=66) and the VATS (n=277) group, disease-free and overall survival were 74.8 vs 70.9% (P=0.4582), 76.4 vs 78.5% (p=0.7626), respectively.

(Conclusion)
NIM system reduced the palsy of recurrent laryngeal nerve during RAMIE while the comparable survival was identified between the two groups. Given its advantage, RAMIE seems to be particularly useful in treating cT3br-T4 cases. Our surgical videos of cT3br-T4 cases will be also presented in the meeting.