bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis, Biological Evaluation, and In Silico Study of N‐(Pyridin‐2/3‐yl)alkanamide Derivatives as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa
Authors: Jaiswal Umesh , Bhopale Abhinetra Jagdish , Srivastava Namita , Yerramsetti Nanaji , Kumar Rajnish , Kumar Lokender , Yadav Ashok Kumar 
Published: October 2024

AbstractThe effectiveness of treating bacterial infections is seriously jeopardized by the emergence of bacterial resistance to chemical therapy. The development of biofilm in bacteria is one of the main causes of resistance to antimicrobial drugs. By developing new antibiofilm medications, quorum sensing (QS) inhibitor was developed as an alternate therapy. QS inhibition, which focuses on the QS signaling pathway, obstructs cell–cell communication. The aim of this work is to develop newer QS inhibitors against Pseudomonas aeruginosa. N‐(Pyridin‐2/3‐yl)alkanamide derivatives were designed as QS inhibitors, and these designed molecules were synthesized. QS inhibitor activity was evaluated for the synthesized compounds (3a–l, 4a–h). The highest QS inhibitor activities for compounds 3k, 4a, and 4c were 11.66 ± 0.11, 14.66 ± 0.15, and 10.66 ± 0.05 mm, respectively. Subsequent molecular docking analyses exhibited moderate to good binding affinity values between −7.1 and −9.3 kcal/mol. Using the in silico method, the physicochemical characteristics of these prepared compounds were examined. Additionally, molecular dynamic simulation was employed to gain a deeper comprehension of stability of the protein and ligand complexes of compounds 3k, 4a, and 4c. The overall findings of the study indicated that N‐(pyridin‐2/3‐yl)alkanamide derivatives might be significant for the development of newer QS inhibitors.
Not in‐sourced here! When does external technology sourcing yield familiar versus novel solutions?
Authors: Klueter Thomas , Ghosh Anindya , Rosenkopf Lori 
Published: October 2024

AbstractResearch SummaryWhen established firms source technology from specialized technology firms, extant research has typically assumed that this in‐sourced technology is novel. We test this assumption by modeling in‐sourcing decisions using a problem‐solution lens wherein firms choose from available external technological solutions to solve their market problems. Since the locus of identification, evaluation, and selection of external solutions remains internal to the firm's R&D personnel, we argue that they frequently prefer familiar over novel solutions. We identify two factors that help firms overcome this preference for familiarity: when top managers focus their attention on the market problem or when they receive feedback from unexpected failures to solve that problem. Our case control analysis of 715 in‐sourced emerging technological solutions in the biopharmaceutical industry offers broad support to our theoretical framework.Managerial SummaryEstablished firms are commonly advised to source novel technologies externally. Yet since this sourcing process is driven by in‐house R&D personnel, we suggest that a firm's choice of external technology solutions may still tend toward familiar ones. We confirm this preference by examining in‐sourcing events of emerging technological solutions by established firms in the biopharmaceutical industry. Despite this preference, we then show that increased top management attention toward a market problem and experiencing unexpected failures in bringing products to market catalyze a receptiveness to novel technological solutions. Our findings help managers in established firms recognize that their claims or intentions to seek novel technology are not always consistent with actual in‐sourcing choices, and suggest when firms can overcome this tendency.
Hydrosedimentological Balance and Modeling as Subsidy for River Recovery‐Related Actions
Authors: da Silva Alexandre Marco 
Published: October 2024

ABSTRACTThe sedimentometric dynamics are part of the environmental dynamics of a watershed and are vulnerable to local environmental changes. Hence, in this study, we (i) investigated the sedimentometric dynamic in three watersheds, (ii) proposed innovative mathematical equations for enhancing the ability to predict the sediment delivery ratio (SDR), and (iii) proposed alternatives to restore the sedimentological equilibrium. In three watersheds, we collected information concerning physiography and land use. Also, for 2 years, water samples and hydrological and sediment‐related data were systematically collected. We then computed a dataset on hydrosedimentology, especially the SDR. We elaborated two mathematical models that predict the SDR, considering the high relation between SDR and the elements of the watershed that go far beyond the “catchment area” information, normally used as basic and unique information for computing SDR values. We also proposed alternatives for environmental control and/or recovery. Such alternatives are based on the sedimentometric dynamics of the watersheds and their vulnerability to degradation. The execution of these actions is vital to provide a local sedimentometric balance and, among other gains, to recover/conserve the environmental quality of the streams and rivers that form the river network of the watershed.
Saturated Absorption Spectroscopy
Authors: Raven Will 
Published: October 2024

AbstractIn this chapter, we explore the clever spectroscopy technique known as saturated absorption spectroscopy. This technique is used to remove Doppler profiles from spectroscopic signals. We will learn how saturated absorption spectroscopy works, including the roles of probe and pump beams, and the resulting spectral features. Additionally, we will examine the artifacts, specifically crossover features (V , $$\Lambda $$
Λ
, and X crossovers), that may appear due to this technique and understand the conditions under which they occur. Practical examples using various atoms, advanced techniques for achieving crossover-free spectroscopy, and potential issues are also discussed.
Analysis of Circuit-Based RHBD Techniques
Authors: Aguiar Ygor Quadros de , Wrobel Frédéric , Autran Jean-Luc , García Alía Rubén 
Published: October 2024

AbstractThis chapter focuses on circuit-level techniques, completing the analysis of radiation hardening by design (RHBD) methods across various design abstraction levels. Here, we evaluate the charge sharing effect, considering its dependence on cell placement and logic synthesis. Subsequently, an optimization methodology is proposed to enhance overall circuit hardness through signal probability–based pin swapping.
Planetare Gesundheit und psychische Gesundheit
Authors: Grosskopf Charlotte M. , Dauterstedt Helen , Severus W. Emanuel , Bauer Michael , Reininger Klaus Michael , Scharping Katharina , Nikendei Christoph 
Published: October 2024

ZusammenfassungDer Klimawandel stellt die größte globale Gesundheitsbedrohung des 21. Jahrhunderts dar. Treibhausgasemissionen und die hierdurch steigenden Durchschnittstemperaturen führen zu Hitzewellen, Dürre, Wasser- und Nahrungsmangel, Extremwetterereignissen, dem Anstieg des Meeresspiegels, Migrationsbewegungen sowie dem Verlust von Biodiversität und dem Untergang von Ökosystemen, wie wir sie kennen. Bereits dafür, dass die globale Durchschnittstemperatur bis 2029 maximal um 1,5 °C steigt, sind nach aktuellen Schätzungen viel umfangreichere gesellschaftliche Maßnahmen als bisher erforderlich. Doch nicht nur der Klimawandel, sondern auch andere menschengemachte Faktoren wie Lärm, Licht, Feinstaub und Plastik bedrohen die Gesundheit unseres Planeten und damit unweigerlich auch die Gesundheit des Menschen – sowohl die körperliche als auch die psychische. Dieser Artikel erweitert das DGPPN-Positionspapier „Klimawandel und psychische Gesundheit“ um den Begriff Planetare Gesundheit. Insbesondere die normative Dimension der Canmore-Erklärung zur Planetaren Gesundheit, Transdisziplinarität als Wissenschaftsprinzip sowie mögliche konkrete Handlungsanweisungen sollen hier in ihrer besonderen Relevanz für die Psychiatrie, Psychotherapie und die sprechende Medizin dargestellt und die Zusammenhänge grafisch illustriert werden.
Axes-aligned non-linear optimized PnP algorithm
Authors: Roch Peter , Shahbaz Nejad Bijan , Handte Marcus , Marrón Pedro José 
Published: October 2024

AbstractPose estimation is an important component of many real-world computer vision systems. Most existing pose estimation algorithms need a large number of point correspondences to accurately determine the pose of an object. Since the number of point correspondences depends on the object’s appearance, lighting and other external conditions, detecting many points may not be feasible. In many real-world applications, the movement of objects is limited, e.g. due to gravity. Hence, detecting objects with only three degrees of freedom is usually sufficient. This allows us to improve the accuracy of pose estimation by changing the underlying equations of the perspective-n-point problem to three variables instead of six. By using the simplified equations, our algorithm is more robust against detection errors with limited point correspondences. In this article, we study three scenarios where such constraints apply. The first one is about parking a vehicle on a specific spot. Here, a stationary camera is detecting the vehicle to assist the driver. The second scenario describes the perspective of a moving camera detecting objects in its environment. This scenario is common for driver assistance systems, autonomous cars or mobile robots. Third, we describe a camera observing objects from a birds-eye view, which occurs in industrial applications. In all three scenarios, observed objects can only move in the ground plane and rotate around the vertical axis. Hence, three degrees of freedom are sufficient to estimate the pose. Experiments with synthetic data and real-world photographs have shown that our algorithm outperforms state-of-the-art pose estimation algorithms. Depending on the scenario, our algorithm is able to achieve 50% better accuracy, while being equally fast.
Virtual numerical control: an approach towards autonomous manufacturing with a case study in welding
Authors: Nasser Mohamed A. , Asy Mohab M. 
Published: October 2024

AbstractToday’s customer lifestyles have reshaped their expectations and preferences, driving a growing demand for tailor-made products. While current conventional manufacturing (MNF) systems are robust, they often lack the flexibility needed to accommodate customization. Most MNF systems, despite advances in technology and machinery, still rely on executing predefined instructions, limiting their flexibility. In contrast, human workers excel at handling product variations due to their cognitive abilities, which allow them to perceive, analyze, and make appropriate decisions to adapt to changing conditions. This study introduces virtual numerical control (VNC) as a solution to upgrade MNF systems and overcome these limitations. VNC aims to transform MNF systems into cognitive entities capable of autonomous decision-making, enabling greater flexibility to meet customization demands. To demonstrate the potential of VNC, we implemented it in a welding system as a practical case study. The results showed that VNC enabled the system to operate autonomously. It accurately identified the shape of the objects to be welded, determined the appropriate welding paths, and executed them with high precision, all without human intervention. This highlights the significant potential of VNC technology for broader applications in industrial automation in welding and beyond.
Numerical model as a tool for the optimisation of performance of a TEG generator for recovering waste heat from process gas
Authors: Górszczak Piotr , Rywotycki Marcin , Fidura Weronika 
Published: October 2024

AbstractThe article focuses on the issue of efficiently recovering waste heat from low-exergy process gases, which poses a significant challenge for improving energy efficiency in many industrial sectors. To address this problem, the application of a thermoelectric generator (TEG) has been proposed, allowing for the direct conversion of thermal energy into electrical energy. In the course of the research, experimental measurements were conducted for process gases at temperatures of 240 °C and 300 °C, along with CFD (computational fluid dynamics) simulations using Ansys Fluent 2023 R2 software. These simulations enabled the analysis of the temperature distribution in the TEG and the determination of the safe operating range of the device for process gas temperatures of 350 °C, 400 °C and 450 °C. The results obtained from both experiments and simulations demonstrated the effectiveness of the TEG in recovering waste heat from low-exergy gases. Additionally, these findings suggest the potential for scaling the solution to larger industrial systems, making TEG a promising technology for long-term sustainable development efforts. The developed numerical model proved to be a valuable tool in the design of TEG systems, allowing for the analysis and optimization of heat recovery systems. The innovation of the solution lies in the use of TEG for efficiently utilising waste heat from low-temperature gases, which holds significant potential for improving energy efficiency in processes where traditional energy recovery technologies are not effective.
In vivo pharmacokinetic, pharmacodynamic and brain concentration comparison of fentanyl and para-fluorofentanyl in rats
Authors: Canfield Jeremy R. , Sprague Jon E. 
Published: October 2024

Abstract
In 2022, para-fluorofentanyl (pFF) rose to the 6th most reported drug and the most reported fentanyl analog in the United States according to the Drug Enforcement Administration (DEA). pFF differs from fentanyl by the addition of a single fluorine group. To date, pFF has not been extensively evaluated in vivo and is frequently seen in combination with fentanyl. In the present study, the pharmacodynamic (PD) and pharmacokinetic (PK) properties and brain region-specific concentrations of pFF were evaluated in male Sprague–Dawley rats and compared to fentanyl. A 300 μg/kg subcutaneous dose of fentanyl or pFF was administered to assess PD and PK parameters as well as brain region concentrations. PD parameters were evaluated via a tail flick test to evaluate analgesia and core body temperature to measure hypothermia, a surrogate marker of overall opioid toxicity. Fentanyl and pFF were found to be equally active at the tested dose in terms of tail flick response with both compounds producing an analgesic response that lasted up to 240 min post-drug treatment. pFF induced a significantly greater hypothermic effect compared to fentanyl with a maximum temperature decrease of −5.6 ℃. Plasma PK parameters (T1/2, AUC, etc.) did not differ between fentanyl and pFF. However, pFF concentrations in the medulla, hippocampus, frontal cortex and striatum were more than two times the fentanyl concentrations. The increase in brain concentrations and greater hypothermic effect suggests that pFF is potentially more dangerous than fentanyl.
Thiopurine S‑methyltransferase- and indolethylamine N‑methyltransferase-mediated formation of methylated tellurium compounds from tellurite
Authors: Tanaka Yu-ki , Takata Ayuka , Takahashi Karin , Yamagishi Yoshikazu , Fukumoto Yasunori , Suzuki Noriyuki , Ogra Yasumitsu 
Published: October 2024

Abstract
Tellurium (Te) is a metalloid widely used in various industries. However, its toxicological impact on humans is poorly understood. In this study, we investigated the role of two methyltransferases, thiopurine S‑methyltransferase (TPMT) and indolethylamine N‑methyltransferase (INMT), in the methylation of tellurite, an inorganic Te oxyanion. The products of the reaction of Te compounds catalyzed by recombinant human TPMT and/or INMT were analyzed by liquid chromatography hyphenated to inductively coupled plasma mass spectrometry (LC-ICP-MS) and gas chromatography mass spectrometry (GC-MS). We found that TPMT catalyzes the methylation of non-methylated Te and methanetellurol to generate dimethyltelluride. On the other hand, INMT catalyzes the methylation of methanetellurol and dimethyltelluride to produce trimethyltelluronium ion, a metabolite excreted into animal urine. We conclude that TPMT and INMT are cooperatively responsible for the detoxification of Te oxyanions through methylation to form trimethyltelluronium ions.
Special issue: nerve compression syndromes “Brachioradialis, or “High Wartenberg”, syndrome – compression of the sensory branch of the radial nerve in the proximal forearm
Authors: Hagert Elisabet , Azocar Camila , Jedeskog Ulrika , Hantouly Ashraf 
Published: October 2024

Abstract
Purpose
Compression of the sensory branch of the radial nerve (SBRN) in the proximal forearm is an uncommon condition, leading to both motor and sensory deficits. The aim of this study is to assess the surgical outcomes of SBRN release at the level of the brachioradialis arcade.

Methods
A retrospective study of prospectively collected data was conducted on patients undergoing brachioradialis release (BRR) from March 2014 to March 2021. The measured outcomes included quick-DASH (Disability of the Arm Shoulder Hand questionnaire), work-DASH, visual analog scale (VAS) scores for pain, and patient satisfaction with surgery, at a minimum six month follow-up.

Results
A total of twenty patients (mean age of 44.1 (range 25–62) were included in this study, of which nine (45%) were males. Eleven patients (55%) underwent isolated BRR, while the other nine patients (45%) underwent concomitant BRR and lacertus release. The three most common presenting symptoms in patients with isolated BRS were radiovolar forearm pain (100%), disturbed sensation in the SBRN territory (85%), and hand/thumb fatigue (75%). Forearm pain and fatigue were found in all patients with combined BRS and lacertus syndrome. The response rate for the functional outcome scores was 65% (13/20). Quick-DASH significantly improved (preoperative 29.6 (range 13.6–57.5) to postoperative 6.9 (range 0–27.27), p < 0.0001) as did the work DASH (p < 0.0001). Follow-up VAS Pain was 1 and satisfaction with surgery 9.6.

Conclusion
BRS is an uncommon radial nerve compression syndrome in the proximal forearm that differs from the more commonly recognized radial tunnel syndrome. It presents with radio-volar forearm pain, disturbed sensation in the SBRN distribution, and loss of hand/thumb endurance. Minimally invasive BRR immediately restores wrist extension strength, significantly improves DASH scores, and yields positive outcomes at a minimum six-month follow-up.
Consistent spawning season of the sea urchin Sterechinus neumayeri in the Ross Sea over 5° of latitude: a role for an endogenous oscillator
Authors: Sewell Mary A. , Heimeier Dorothea , Gallego Ramon 
Published: October 2024

AbstractIn temperate broadcast spawners, gamete release within the reproductive period is often triggered by exogenous cues such as phytoplankton concentration, seawater temperature, or day length (photoperiod). In Antarctica, little is known about cues to spawning, even within well-studied species, such as the sea urchin Sterechinus neumayeri. Here, we determine the spawning time in S. neumayeri using the time of appearance of embryos and larvae in plankton samples collected from the sea ice with a collapsible plankton net. Collections in McMurdo Sound and at three locations along the Victoria Land Coast of the Ross Sea [Cape Hallett (72°S), Terra Nova Bay (74°S), and Granite Harbour (77°S)] over a period of eight years showed that although there were differences in embryo and larval abundance between locations, multiple spawning events occurred during late October/early November to December, regardless of latitude, and appeared unrelated to moon phase. Exogenous spawning cues are limited in the Ross Sea during the early summer: sites are covered with sea ice with limited light penetration and water temperature is generally stable. As the spawning season on the Antarctic Peninsula and maritime Antarctic is also in October–December, we hypothesize that an endogenous cue plays a role in setting the time of gametogenesis and spawning, perhaps set by phytodetrital inputs in the late summer, as in the seasonally breeding sea urchins from the deep sea. Further research will be needed to test this hypothesis in Antarctic populations of S. neumayeri.
Equestrian-associated injuries of the hand: a retrospective analysis of injury mechanisms and patterns
Authors: Ritter Benedikt , Dastagir Nadjib , Tamulevicius Martynas , Bucher Florian , Obed Doha , Vogt Peter M. , Dastagir Khaled 
Published: October 2024

Abstract
Introduction
Hand injuries are frequently caused by sports and are associated with long periods of inability to work and high economic health costs. After ball sports and cycling, the most common cause of hand injuries is horseback riding. Therefore, measures should be taken to prevent these risks and increase safety in sports, however data characterizing equestrian sports-associated injuries are limited.

Materials and Methods
A retrospective monocentric cohort study was performed including 39 patients (mean age: 35 ± 2.6 (range 9–65) years, female 89.7% who sustained an injury to the hand while practicing equestrian sports during 2016–2021 and presented to our hand surgery center. Data analysis was performed to characterize the trauma mechanism and injury patterns by evaluating the clinical information system and conducting telephone interviews.

Results
Overall, 53.8% of the injuries occurred while leading the horse owing to traction by bridles or a lead rope on the fingers, whereas only 33.3% were caused by a fall and 12.8% by a bite injury. The majority (87.2%) of cases were injuries to the phalanges (metacarpus: 7.7%; carpus: 5.1%). Fractures were present in 51.3% of cases. The most serious injuries included avulsion amputations in 23.1% of patients (10.3% subtotal; 12.8% total amputation).

Conclusions
Equestrian-associated injuries occur more frequently during horse handling than riding, resulting in severe avulsion amputations due to traction of the lunge or bridle, requiring complex microsurgical treatment. We recommend that appropriate protective gloves are worn for prevention of hand injuries. Additionally, the use of self-opening panic hooks with overload protection can prevent excessive traction.

Level of evidence
III
Ahmed’s sub-flap mattress suture deep sclerectomy assessment with Ultrasound Biomicroscopy
Authors: Habib Mina Maged , Hilmy Gihan Mohamed , AbdelRahman Ahmed Mostafa , Kotb Mohamed Sabry 
Published: October 2024

Abstract
Purpose
To assess the efficacy of adding Ahmed’s sub-flap mattress suture to deep sclerectomy (DS).

Methods
Forty eyes with open angle glaucoma were assigned randomly into two groups: Group A: underwent DS with Ahmed’s sub-flap mattress suture. Group B: underwent conventional DS. Patients were followed up closely for 6 months with serial IOP measurements and ultrasound biomicroscopy (UBM) was used to assess the surgical site functionally and anatomically at the first and sixth month.

Results
Adding Ahmed’s sub-flap mattress suture improved the IOP lowering effect of DS significantly from 43% in group B to 53% in group A at 6-month (p = 0.027). IOP in group A was at 1 week, 1 month and 6-month visits (7.9 ± 1.3, 11.7 ± 2.2 and 13.3 ± 1.9 mmHg respectively) compared to group B (10.1 ± 4.6, 14.1 ± 5.2 and 16.8 ± 4.1 mmHg respectively) (p = 0.025, 0.041 and 0.001 respectively). UBM parameters were significantly larger in group A at 1 and 6 months. Strong statistically significant negative correlations were established between IOP and all the UBM parameters apart from intrascleral lake height at the first and sixth month (p < 0.01 in all of them). Finally, significant correlations were found between IOP at 6 months and whole bleb anteroposterior length and height at 1 month (p = 0.001).

Conclusion
Adding Ahmed’s sub-flap mattress suture to routine DS is an effective economical addition that will enhance the IOP lowering effect of DS. Also, assessment of the bleb by UBM is useful in predicting the success of deep sclerectomy surgery.