bluuebunny/crossref_metadata_2025_split huggingface dataset:
What if things go wrong in co-producing health services? Exploring the implementation problems of health care co-production
Authors: Palumbo Rocco , Manna Rosalba 
Published: December 2017

Abstract
Patient-centered care and health services’ co-production are the cornerstones of the health care system of the future. These constructs rely on the reconceptualization of the patient as a co-deliverer of care. While studies about the intrinsic value-added of health services’ co-production are prominent, the risks of value co-destruction attached to patient involvement have been widely neglected. In an attempt to fill this gap, this paper draws on the ‘health literacy’ perspective to conceptually explore the ‘dark side’ of health services’ co-production. Value co-destruction is understood as a two-way street, where both the health care professionals and the patients are likely to walk, either intentionally or unintentionally. Individual and organizational health literacy are proposed as two essential ingredients of the recipe for effective health services’ co-production, reducing the risks of value co-destruction in health services’ provision.
On complete monotonicity of certain special functions
Authors: Zhang Ruiming 
Published: December 2017

Given an entire function

f
(
z
)

f(z)

that has only negative zeros, we shall prove that all the functions of type

f

(
m
)

(
x
)

/

f

(
n
)

(
x
)
,

m
>
n

f^{(m)}(x)/f^{(n)}(x),\ m>n

are completely monotonic. Examples of this type are given for Laguerre polynomials, ultraspherical polynomials, Jacobi polynomials, Stieltjes-Wigert polynomials,

q
q

-Laguerre polynomials, Askey-Wilson polynomials, Ramanujan function,

q
q

-exponential functions,

q
q

-Bessel functions, Euler’s gamma function, Airy function, modified Bessel functions of the first and the second kind, and the confluent basic hypergeometric series.
Daily decision-making about food during pregnancy: a New Zealand study
Authors: Pullon Susan , Ballantyne Angela , Macdonald Lindsay , Barthow Christine , Wickens Kristin , Crane Julian 
Published: December 2017

Summary
Pregnancy has always been a life-changing event for women and their families, but societal concern about pregnancy and motherhood has become intense in the digital age. The role of health promotion agencies and others supplying health-related resources about lifestyle behaviours is both important and in need of scrutiny. Ever increasing advice for pregnant women, their families and health professionals, abounds. This study of decision making during pregnancy investigated how women made everyday decisions during pregnancy about food and drink, as well as dietary supplements and medications, alcohol and recreational drugs. This qualitative interview study was a side-arm to a double-blind randomized, placebo-controlled trial conducted with pregnant women in Wellington New Zealand, 2013–2016. Data from interviews with 20 women were analysed using inductive thematic analysis. In relation to decision-making about lifestyle behaviours, five themes emerged—Information about food; Wanted and unwanted advice; Worry, anxiety and indecision; Making daily decisions about food; Changes in decision making over time. Participating women talked more about food selection and restriction advice than any other lifestyle topic. Analysis demonstrated concern about information accuracy and overload from multiple, diverse sources. Women described learning how to assess resource credibility, how to develop decision-making skills, and who to trust. The study raises important questions about how the health information environment, despite best intentions, can be confusing or potentially harmful. The study underlines the continued importance of the role health professionals have in not only interpreting information to discuss individualized advice, but also in empowering pregnant women to develop lifestyle-related decision-making skills.
The ancestral animal genetic toolkit revealed by diverse choanoflagellate transcriptomes
Authors: Richter Daniel J. , Fozouni Parinaz , Eisen Michael B. , King Nicole 
Published: December 2017

AbstractThe changes in gene content that preceded the origin of animals can be reconstructed by comparison with their sister group, the choanoflagellates. However, only two choanoflagellate genomes are currently available, providing poor coverage of their diversity. We sequenced transcriptomes of 19 additional choanoflagellate species to produce a comprehensive reconstruction of the gains and losses that shaped the ancestral animal gene repertoire. We find roughly 1,700 gene families with origins on the animal stem lineage, of which only a core set of 36 are conserved across animals. We find more than 350 gene families that were previously thought to be animal-specific actually evolved before the animal-choanoflagellate divergence, including Notch and Delta, Toll-like receptors, and glycosaminoglycan hydrolases that regulate animal extracellular matrix (ECM). In the choanoflagellateSalpingoeca helianthica, we show that a glycosaminoglycan hydrolase modulates rosette colony size, suggesting a link between ECM regulation and morphogenesis in choanoflagellates and animals.Data AvailabilityRaw sequencing reads: NCBI BioProject PRJNA419411 (19 choanoflagellate transcriptomes), PRJNA420352 (S. rosettapolyA selection test)Transcriptome assemblies, annotations, and gene families:https://dx.doi.org/10.6084/m9.figshare.5686984Protocols:https://dx.doi.org/10.17504/protocols.io.kwscxee
Cytoskeletal mechanisms of axonal contractility
Authors: Mutalik S. P. , Joseph J. , Pullarkat P.A. , Ghose A. 
Published: December 2017

ABSTRACTMechanotransduction is likely to be an important mechanism of signalling in thin, elongated cells like neurons. Maintenance of pre-stress or rest tension may facilitate mechanotransduction in these cells. In recent years, functional roles for mechanical tension in neuronal development and physiology are beginning to emerge but the cellular mechanisms regulating neurite tension remain poorly understood. Active contraction of neurites is a potential mechanism of tension regulation. In this study, we have explored cytoskeletal mechanisms mediating active contractility of neuronal axons. We have developed a simple assay where we evaluate contraction of curved axons upon trypsin-mediated detachment. We show that curved axons undergo contraction and straighten upon de-adhesion. Axonal straightening was found to be actively driven by actomyosin contractility, while microtubules may subserve a secondary role. We find that while axons show a monotonous decrease in length upon contraction, subcellularly, the cytoskeleton shows a heterogeneous contractile response. Further, using an assay for spontaneous development of tension without trypsin-induced de-adhesion, we show that axons are intrinsically contractile. These experiments, using novel experimental approaches, implicate the axonal cytoskeleton in tension homeostasis. Our data suggest that while globally the axon behaves as a mechanical continuum, locally the cytoskeleton is remodelled heterogeneously.
The ERK MAPK pathway modulates Gq-dependent locomotion in>Caenorhabditis elegans
Authors: Coleman Brantley , Topalidou Irini , Ailion Michael 
Published: December 2017

AbstractThe heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we performed a forward genetic screen in the nematodeCaenorhabditis elegansfor suppressors of the hyperactivity and exaggerated waveform of an activated Gq mutant. We isolated two mutations affecting the MAP kinase scaffold protein KSR-1 and found that KSR-1 modulates locomotion downstream of or in parallel to the Gq-Rho pathway. Through epistasis experiments, we found that the core ERK MAPK cascade is required for Gq-Rho regulation of locomotion, but that the canonical ERK activator LET-60/Ras may not be required. Through neuron-specific rescue experiments, we found that the ERK pathway functions in head acetylcholine neurons to control Gq-dependent locomotion. Additionally, expression of activated LIN-45/Raf in head acetylcholine neurons is sufficient to cause an exaggerated waveform phenotype and hypersensitivity to the acetylcholinesterase inhibitor aldicarb, similar to an activated Gq mutant. Taken together, our results suggest that the ERK MAPK pathway modulates the output of Gq-Rho signaling to control locomotion behavior inC. elegans.
In situ architecture of the algal nuclear pore complex
Authors: Mosalaganti Shyamal , Kosinski Jan , Albert Sahradha , Schaffer Miroslava , Plitzko Jürgen M. , Baumeister Wolfgang , Engel Benjamin D. , Beck Martin 
Published: December 2017

AbstractNuclear pore complexes (NPCs) span the nuclear envelope and mediate nucleocytoplasmic exchange. They are a hallmark of eukaryotes and are deeply rooted in the evolutionary origin of cellular compartmentalization. NPCs have an elaborate architecture that has been well studied in vertebrates. Whether this architecture is unique or varies significantly in other eukaryotic kingdoms remains unknown, predominantly due to missing in situ structural data. Here, we report the architecture of the algal NPC from the early branching eukaryote Chlamydomonas reinhardtii and compare it to the human NPC. We find that the inner ring of the Chlamydomonas NPC has an unexpectedly large diameter, and the outer rings exhibit an asymmetric oligomeric state that is unprecedented compared to all previously proposed models of NPC architecture. Our study provides evidence that the NPC is subject to substantial structural variation between species. The divergent and conserved features of NPC architecture provide insights into the evolution of the nucleocytoplasmic transport machinery.
Probing cellular response to topography in three dimensions
Authors: Paul Colin D. , Hruska Alex , Staunton Jack R. , Burr Hannah A. , Daly Kathryn M. , Kim Jiyun , Jiang Nancy , Tanner Kandice 
Published: December 2017

ABSTRACTBiophysical aspects of in vivo tissue microenvironments include microscale mechanical properties, fibrillar alignment, and architecture or topography of the extracellular matrix (ECM). These aspects act in concert with chemical signals from a myriad of diverse ECM proteins to provide cues that drive cellular responses. Here, we used a bottom-up approach to build fibrillar architecture into 3D amorphous hydrogels using magnetic-field driven assembly of paramagnetic colloidal particles functionalized with three types of human ECM proteins found in vivo. We investigated if cells cultured in matrices comprised of fibrils of the same size and arranged in similar geometries will show similar behavior for each of the ECM proteins tested. We were able to resolve spatial heterogeneities in microscale mechanical properties near aligned fibers that were not observed in bulk tissue mechanics. We then used this platform to examine factors contributing to cell alignment in response to topographical cues in 3D laminin-rich matrices. Multiple human cell lines extended protrusions preferentially in directions parallel or perpendicular to aligned fibers independently of the ECM coating. Focal adhesion proteins, as measured by paxillin localization, were mainly diffuse in the cytoplasm, with few puncta localized at the protrusions. Integrin β1 and fascin regulated protrusion extension but not protrusion alignment. Myosin II inhibition did not reduce observed protrusion length. Instead, cells with reduced myosin II activity generated protrusions in random orientations when cultured in hydrogels with aligned fibers. Similarly, myosin II dependence was observed in vivo, where cells no longer aligned along the abluminal surfaces of blood vessels upon treatment with blebbistatin. These data suggest that myosin II can regulate sensing of topography in 3D engineered matrices for both normal and transformed cells.
The role of mental health and challenging behaviour in the quality of life in people with intellectual disabilities in Spain
Authors: Peña-Salazar Carlos , Arrufat Francesc , Fontanet Abel , Font Josep , Mas Silvia , Roura-Poch Pere , Santos Josep Manel 
Published: December 2017

Purpose
The purpose of this paper is to determine the relation between quality of life (QoL), mental illness, challenging behaviour and institutionalisation in an adult population with intellectual disabilities (ID).

Design/methodology/approach
The study assessed the QoL and its conditioning factors in 142 subjects with different degrees of ID. The GENCAT and Quality of Life in Late Stage Dementia scale were used to evaluate QoL, the Psychiatric Assessment Schedule for Adults with Developmental Disability and Diagnostic Assessment for the Severely Handicapped-II scale to assess mental illness and the Inventory for Client and aetiology Planning scale to assess challenging behaviour.

Findings
Individuals who live in residential care homes were found to have significantly impaired QoL (<0.001). Individuals with challenging behaviour presented significantly lower QoL, regardless of ID aethiology and degree, while psychiatric disorders did not seem to have a direct influence on individual QoL.

Originality/value
This paper provides new insight into the importance of challenging behaviour and psychiatric disorders in the QoL of individuals with ID.
Improving the quality of business process descriptions of public administrations
Authors: Ferrari Alessio , Witschel Hans Friedrich , Spagnolo Giorgio Oronzo , Gnesi Stefania 
Published: December 2017

Purpose
Business processes (BPs) of public administrations (PAs) are often described in the form of written procedures or operational manuals. These business process descriptions are expected to be properly understood and applied by civil servants, who have to provide legally compliant service provisions to the citizens. However, process descriptions in the PA are sometimes hard to read, ambiguous, or vague, leading to false interpretations or even incorrect execution of the processes. The purpose of this paper is to focus on improving the descriptions of BPs to be used in PAs.

Design/methodology/approach
To this end, the authors present an in-depth domain analysis, including a literature review and interviews with PA stakeholders belonging to different realities. From this analysis, the authors identified a set of 52 typical defects of process descriptions.

Findings
The authors provide a set of guidelines and a template to constrain the definition of these documents and to mitigate the identified defects. Furthermore, the authors outline research challenges in the field of quality assessment of textual process descriptions for the PA.

Research limitations/implications
This paper addresses the needs of any PA officer who has to write an official procedure or operational manual, and should be studied by researchers who wish to provide automatic strategies to check the quality of these documents.

Originality/value
Text quality issues have been addressed in various fields (e.g. requirements engineering), but not in the area of BP descriptions of PAs. The contribution consists in the study of the quality issues that occur and create problems in the practice of this particular domain. Based on this insight, we provide directions for research that will find solutions to mitigate the issues.
Empirical assessment of factors influencing potential of manufacturing flexibility in organization
Authors: Mishra Ruchi , Pundir Ashok K. , Ganapathy L. 
Published: December 2017

PurposeThe purpose of this paper is to develop an understanding of factors and their associated attributes that largely influence achievement of manufacturing flexibility.Design/methodology/approachUsing two sequential phases consisting of literature review, plant visits and focus group interviews, the study identifies key factors that influence manufacturing flexibility and develop and validate these factors through postal survey. In total, 211 responses from multiple industries were collected to analyze the data.FindingsThe study identifies and develops eight factors and their associated 39 attributes that largely influence achievement of manufacturing flexibility. Out of eight underlying constructs, operational improvement practices construct reported highest level of variance followed by advanced manufacturing technology, human resource practices, supplier flexibility, supplier integration, customer integration, product-process technology integration and marketing and manufacturing integration.Research limitations/implicationsThe scope of the study is limited to the plant level. Therefore, other strategic-level factors, such as business strategy, the amount of investment, leadership quality have not been addressed in this research.Practical implicationsThe findings can assist managers in improving the level of manufacturing flexibility by specifying key factors essential for achievement of manufacturing flexibility. An important implication for managers is that identification of factors should be followed by proper assessment and implementation so as to remain competitive in the market.Originality/valueThe findings provide insight into the factors that facilitate in achievement of manufacturing flexibility.
A review of service quality and service delivery
Authors: Alzaydi Zyad M. , Al-Hajla Ali , Nguyen Bang , Jayawardhena Chanaka 
Published: December 2017

PurposeThe purpose of this paper is to provide researchers with an overview of the service quality and delivery domain, focussing on the inclusion of customer co-production and customer integration. Specifically, this paper concentrates on service quality (including quality measurement), the service environment, controls and their consequences.Design/methodology/approachA comprehensive review of the literature is conducted, analysed and presented.FindingsThe review shows that service delivery is both complex and challenging, particularly when considering the unique characteristics of services and the high level of customer involvement in their creation. The facilitation, transformation and usage framework identifies how failures can occur at each stage of service delivery, beginning with the characteristics of the service environment, while control theory offers insights into the formal and informal controls that may be applied in the facilitation and transformation stages, which may reduce the likelihood or extent of such failures.Originality/valueDespite the fact that it is widely accepted that service quality is an antecedent to customer satisfaction, it is surprising that this customer co-creation aspect has been largely neglected in the extant literature. As such, the role that customer co-production plays in service quality performance has been examined in this paper. It is hoped that this examination will enhance both theoretical and practical understanding of service quality. It would be useful to find modern tools that can help in improving service quality performance.
Examining the factors influencing knowledge management system (KMS) adoption in small and medium enterprises SMEs
Authors: Shrafat Fayiz Dahash 
Published: December 2017

Purpose
The potential for the adoption of a knowledge management system (KMS) is becoming a crucial matter in small and medium enterprises (SMEs); however, there is a scarcity of studies related to KMS adoption in SMEs. Therefore, the purpose of this paper is to advance further our understanding of the factors that influence the KMS adoption process among SMEs.

Design/methodology/approach
The collected sample size was 247 respondents. For statistical analysis, Smart partial least square (PLS) (a structural model-based tool) was used to build, run and validate the process model. PLS regression techniques were used to analyze the latent constructs. Smart PLS exhibits both the measurement model and the structural model.

Findings
The results indicate that knowledge management capabilities, knowledge sharing, organizational learning capabilities and IT capabilities are the significant factors which influence KMS adoption. This study also identifies some unexpected results.

Research limitations/implications
The number of responses obtained from the survey was rather small. However, a larger number of responses would probably have resulted in a more accurate finding. Additionally, this study should be verified via a larger sample to increase its generalization.

Practical implications
The result of this study will provide SMEs with valuable guidelines to better understand what factors should be considered as highly important and thus providing decision makers and managers with valuable insights to increase the adoption level of KMSs.

Originality/value
The study addresses the research gap by developing and empirically validating a research model of KMS adoption from a different perspective that incorporates critical issues which have never been simultaneously examined.
Account-based recommenders in open discovery environments
Authors: Hahn Jim , McDonald Courtney 
Published: December 2017

Purpose
This paper aims to introduce a machine learning-based “My Account” recommender for implementation in open discovery environments such as VuFind among others.

Design/methodology/approach
The approach to implementing machine learning-based personalized recommenders is undertaken as applied research leveraging data streams of transactional checkout data from discovery systems.

Findings
The authors discuss the need for large data sets from which to build an algorithm and introduce a prototype recommender service, describing the prototype’s data flow pipeline and machine learning processes.

Practical implications
The browse paradigm of discovery has neglected to leverage discovery system data to inform the development of personalized recommendations; with this paper, the authors show novel approaches to providing enhanced browse functionality by way of a user account.

Originality/value
In the age of big data and machine learning, advances in deep learning technology and data stream processing make it possible to leverage discovery system data to inform the development of personalized recommendations.
An overview of ICD medical classification for the information professional
Authors: Cervone H. Frank 
Published: December 2017

Purpose
Informatics work introduces information professionals to taxonomies and other classification systems outside the boundaries of traditional bibliographic systems. This paper aims to provide an overview of the International Statistical Classification of Diseases and Related Health Problems (ICD) for informaticians and information professionals who may not have worked with the system previously.

Design/methodology/approach
In this paper, the author reviews the purpose, history, current use and future trends of the ICD classification system.

Findings
ICD is used globally as a standard vocabulary for medical diagnoses and, in the USA, for medical procedures in hospitals. Understanding the classification system is vital to working with clinical medical data.

Originality/value
The ICD classification system is not commonly used by information professionals. This paper provides a brief overview that will familiarize the information professional with the standard and its uses related to medical practice.