bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diminished functional segregation and resilience are associated with symptomatic severity and cognitive impairments in schizophrenia: a large-scale study
Authors: Yan Haohao , Han Yiding , Xu Xijia , Zhang Hongxing , He Yiqun , Xie Guojun , Li Huabing , Liu Feng , Li Ping , Zhao Jingping , Guo Wenbin 
Published: September 2024

BackgroundThe research findings on the topological properties of functional connectomes (TP-FCs) in patients with schizophrenia (SZPs) exhibit inconsistencies and contradictions, which can be attributed to limitations such as small sample sizes and heterogeneous data processing techniques.AimsTo address these limitations, we conducted a large-scale study. Uniform data processing flows were employed to investigate the aberrant TP-FCs and the associations between TP-FCs and symptoms or cognitions (A-TP-SCs) in SZPs.MethodsThe large-scale study included six datasets from four sites, involving 497 SZPs and 374 healthy controls (HCs). A uniform process for imaging data preprocessing and functional connectivity matrix configuration was used. ComBat was employed for data harmonisation, and various TPs were calculated. We explored between-group differences in brain functional integration (FI) and functional segregation (FS) measured with TP-FCs, and conducted partial correlation analyses, with adjustments for age, gender and educational level, to identify A-TP-SCs.ResultsCompared with random networks and HCs, SZPs maintained small-worldness and global FI capacity despite their compromised global FS capacity and resilience. A decline in nodal FI and FS capacity was observed in sensory areas, whereas an increase in nodal FI capacity was found in regions associated with cognition and information integration. In addition, associations between TP-FCs and positive symptoms, negative symptoms or cognitive functions including speed of processing, visual learning and the ability to inhibit cognitive interference were identified in SZPs.ConclusionsThe identified A-TP-SCs verified that reductions in FS and resilience indicated pathological impairments in schizophrenia. The A-TP-SCs or TP-FCs, which measured the same attributes of the functional connectomes, exhibited high internal consistency, robustly reinforcing these findings.
Comparative early effectiveness across 14 PsA drugs and 5 classes of PsA treatment: 3-month results from the PRO-SPIRIT study
Authors: Kristensen Lars Erik , Ng Khai Jing , Ngantcha Marcus , Morel Jacques , Lubrano Ennio , Tillett William , Alten Rieke , Chandran Vinod , Martinez Ferrer Àngels , Zhu Baojin , Kennedy Dominika , Holzkämper Thorsten , Gullick Nicola , Kronbergs Andris , Fakhouri Walid , de la Torre Inmaculada , McGonagle Dennis G 
Published: September 2024

BackgroundThe psoriatic arthritis (PsA) Observational Study of Persistence of Treatment (PRO-SPIRIT) assesses effectiveness and persistence of real-world PsA treatments. Ixekizumab (IXE) is an interleukin (IL)-17A inhibitor (i) (IL-17Ai), approved for the treatment of adult PsA.MethodsThe aim of this predefined interim analysis was to report baseline characteristics along with early (3-month) descriptive and comparative real-world effectiveness in patients with PsA prescribed with advanced treatment including IL-17Ai; IXE or secukinumab (SEC), IL-12/23i, IL-23i, tumour necrosis factor (TNFi) or Janus kinase (JAKi).Results1192 patients across 6 countries were analysed. At baseline, patients receiving IXE had longer disease duration and higher previous biological/targeted-synthetic disease-modifying antirheumatic drugs experience than patients starting TNFi and SEC 150, and less concomitant conventional-synthetic DMARD use than TNFi and JAKi. Comparative analyses at 3 months showed that: (a) versus TNFi, IXE exhibited similar improvement in clinical Disease Activity in PsA (cDAPSA) but significantly greater improvement in body surface area affected by psoriasis (BSA) and global assessments (physician GA, patient GA (PatGA)); (b) versus IL-12/23i and IL-23i (pooled), IXE showed significantly greater improvement in cDAPSA and PatGA; (c) IXE was as fast as JAKi in improving joint disease activity. Ad hoc analysis indicated that more patients with active psoriasis (BSA ≥3%) achieved minimal disease activity with IXE than JAKi or IL-12/23i. The responses to SEC varied by dosage.ConclusionsThis study confirms the rapid 3-month effectiveness of IXE on joint disease activity—as fast as TNFi and JAKi (cDAPSA), and exceeding IL-12/23i and IL-23i—along with clear benefits to skin.
Interplay between charge ordering and superconducting correlations in the extended Hubbard model
Authors: Farkašovský Pavol 
Published: September 2024

AbstractWe examine effects of charge ordering on superconducting correlations in the extended Hubbard model with Falicov-Kimball coupling in two dimensions. Charge orderings are generated by f-electron distributions on the localized f orbitals, which act as an internal potential for itinerant d electrons moving in the Hubbard d band. For the small finite cluster of $$L=4 \times 4$$

L
=
4
×
4

sites the model is studied exactly over the complete set of f-electron distributions, while for larger clusters the projector Quantum-Monte-Carlo method and the reduced set of f-electron distributions (the periodic, phase separated and phase segregated configurations) is used. It is found that the enhancement of superconducting correlations in the d-wave channel depends strongly on the type of f-electron ordering and changes significantly with f and d electron concentration ($$n_f$$

n
f

,$$n_d$$

n
d

) as well as with interband Coulomb interaction $$U_{fd}$$

U

fd

. In particular, it is found that for small values of $$U_{fd}$$

U

fd

and $$n_d$$

n
d

the superconducting correlations are the most significantly enhanced for segregated configurations (all f-electrons clump together), for all f-electron concentrations, while for higher d-band fillings axial stripes (bands) with f-electron concentrations $$n_f \sim 0.5$$

n
f

∼
0.5

yield the largest enhancement of superconducting correlations. The region of axial striped phases is systematically reduced with increasing $$U_{fd}$$

U

fd

and for sufficiently large $$U_{fd}$$

U

fd

($$U_{fd}\sim 2$$

U

fd

∼
2

) it persists only in the region of small $$n_f$$

n
f

and $$n_d$$

n
d

values.
First Voltammetric Determination of Karbutylate via Pencil Graphite, Glassy Carbon, and Boron-Doped Diamond Electrodes in Soil Sample
Authors: Bilge Selva , Donar Yusuf Osman , Sınağ Ali 
Published: September 2024

We investigated the electrochemical behavior of carbamate pesticide-type karbutylate (KB) with boron-doped diamond (BDD), glassy carbon (GC), and pencil graphite (PG) electrode, and analytical determination in real samples. Similar to organophosphate insecticides, carbamate pesticides are produced from carbamic acid and are extensively utilized in agriculture, gardens, and residences. Therefore, a rapid and simple detection of KB in real samples is important. Carbon-based electrodes are widely used in electroanalytical chemistry due to their rich surface chemistry, chemical inertness, broad potential window, low background current, and congruency for various demanding applications. Three different carbon-based electrodes were used. The effect of buffer solutions, scan rate, square wave (SWV), and differential pulse voltammetry parameters on the voltammetric response of KB was tested. The optimum working media for all three electrodes was determined as pH 2.00 phosphate buffer solution and voltammetric measurements were carried out in this media. Under optimum experimental conditions, linear calibration dependences for KB were obtained as 6.00 × 10−7–8.00 × 10−5 M, 4.00 × 10−7–8.00 × 10−5 M, and 8.00 × 10−8–8.00 × 10−5 M with a limit of detection of 2.18 × 10−7, 3.71 × 10−8 M, and 2.66 × 10−8 M by the BDD, GC, and PG electrodes, respectively, using SWV. As a result, sensitive determination of KB has been successfully performed using different carbon-based electrodes in real soil samples.
Prevalence of Mental Distress and Its Predictors Among Adult Women Attending Court After Experiencing Gender‐Based Violence: A Cross‐Sectional Study
Authors: Chafuro Getachew , Desalegn Mitiku , Mamo Hanna , Yohannes Tadele 
Published: September 2024

Background: Despite being a universal problem, violence against women is the least acknowledged category of human rights violations worldwide. Long‐term mental health conditions such as anxiety, sadness, and posttraumatic stress disorders are associated with violence against women and girls. Despite its magnitude, severity, and negative consequences, studies on the prevalence of mental distress and associated factors among women who experienced gender‐based violence (GBV) are limited in Ethiopia.Objective: To assess the prevalence of mental distress and associated factors among women who experienced GBV and attended courts in the Hadiya Zone, Central Ethiopia, from July to September 2023.Methods: A cross‐sectional study was conducted among 426 adult women who experienced GBV and attended the courts. A simple random sampling technique was used to select the study subjects. The collected data were entered into EpiData Version 4.6 and then exported to SPSS Version 26 for analysis. A logistic regression model was used to identify independent factors of mental distress. The strength of the associations is presented as odds ratios with 95% CIs, and the results are reported as significant at p values < 0.05.Results: A total of 420 participants were enrolled for a 99.5% response rate. The prevalence of mental distress was 52.6% (95% CI: 49.65–58.85). Mental distress was associated with rural residence (AOR: 2.753; 95%CI = 1.749, 4.332), being concerned about food insecurity (AOR = 2.808; 95%CI = 1.344, 5.864), having a family history of mental illness (AOR = 2.647; 95%CI = 1.488, 4.708), having a husband ever khat use (AOR = 1.918; 95%CI = 1.192, 3.085), and having a husband who married another wife (AOR = 2.209; 95%CI = 1.199, 4.072).Conclusion: The prevalence of mental distress among women who experienced GBV and attended the courts of the Hadiya Zone was high. Place of residence, concern about food insecurity, family history of mental illness, ever khat use, and having a husband who marries another wife were found to have statistically significant associations with mental distress among women who experienced GBV and attended the courts of the Hadiya Zone. Women need to be assessed regularly for GBV during health care visits. Regular counseling, facilitating, and adhering to different GBV coping mechanisms during the waiting time is imperative to overcome this problem.
The Innate Immune System and the TRAIL–Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females
Authors: May Lauren , Hu Bin , Jerajani Preksha , Jagdeesh Akash , Alhawiti Ohud , Cai Lillian , Semenova Nina , Guo Chunqing , Isbell Madison , Deng Xiaoyan , Faber Anthony C. , Pillappa Raghavendra , Bandyopadhyay Dipankar , Wang Xiang-Yang , Neuwelt Alexander , Koblinski Jennifer , Bos Paula D. , Li Howard , Martin Rebecca , Landry Joseph W. 
Published: September 2024

Abstract
There is a significant sex bias in lung cancer, with males showing increased mortality compared with females. A better mechanistic understanding of these differences could help identify therapeutic targets to personalize cancer therapies to each sex. After observing a clear sex bias in humanized mice, with male patient-derived xenograft lung tumors being more progressive and deadlier than female patient-derived xenograft lung tumors, we identified mouse tumor models of lung cancer with the same sex bias. This sex bias was not observed in models of breast, colon, melanoma, and renal cancers. In vivo, the sex bias in growth and lethality required intact ovaries, functional innate NK cells and monocytes/macrophages, and the activating receptor NKG2D. Ex vivo cell culture models were sensitized to the anticancer effects of NKG2D-mediated NK cell and macrophage killing through the TRAIL–Bcl-XL axis when cultured with serum from female mice with intact ovaries. In both flank and orthotopic models, the Bcl-XL inhibitor navitoclax (ABT-263) improved tumor growth control in female mice and required NK cells, macrophages, and the TRAIL signaling pathway. This research suggests that navitoclax and TRAIL pathway agonists could be used as a personalized therapy to improve outcomes in women with lung cancer.
Significance: Lung cancers in females are more susceptible to killing through a TRAIL–Bcl-XL axis, indicating that targeting this axis therapeutically could represent a personalized approach to treat female patients with lung cancer.
Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma
Authors: Shi Wengui , Li Lianshun , Zhao Huiming , Li Zhengyang , Ma Zhijian , Gu Qianlin , Ye Huili , Jiang Xiangyan , Dong Yuman , Qin Long , Zhou Huinian , Yu Zeyuan , Jiao Zuoyi 
Published: September 2024

Abstract
Primary cilia detect and transmit environmental signals into cells. Primary cilia are absent in a subset of ductal carcinomas characterized by distinctive biological activities, and recovery of cilia with normal functionality has been shown to have therapeutic potential in some cancer types. Therefore, elucidation of the underlying mechanism and clinical significance of ciliary loss in ductal carcinomas could help develop effective treatment strategies. Here, we identified a link between Shc1-binding protein (SHCBP1) and cilia in ductal carcinomas. Shcbp1 knockout in transgenic mice profoundly impeded tumor progression and metastasis, prolonging survival. Single-cell transcriptome analysis revealed a functional connection between SHCBP1 deficiency and increased tumor ciliogenesis. SHCBP1 ablation restored ciliogenesis in unciliated ductal carcinoma by promoting the proximity between the midbody remnant (MBR) and centrosome through enhanced Rab8 GTPase activity and Rab8GTP positioning within the MBR. Inhibition of tumor progression by SHCBP1 loss relied on the recovery of ciliogenesis. Analysis of a large cohort of patients with ductal carcinoma revealed a negative correlation between SHCBP1-induced ciliary loss and patient prognosis. Restoring ciliogenesis via SHCBP1 ablation elicited therapeutic effects in patient-derived xenograft models. Together, this study delineates that induction of MBR-centrosome proximity through SHCBP1-deficiency reactivates ciliogenesis, offering unique opportunities for the treatment of unciliated ductal carcinomas.
Significance: SHCBP1 depletion rescues tumor ciliogenesis by enhancing Rab8 GTPase activity to restore the proximity of the midbody remnant to the centrosome, which impedes progression of ductal carcinomas and suggests potential therapeutic strategies.
Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma
Authors: Rahmat Mahshid , Clement Kendell , Alberge Jean-Baptiste , Sklavenitis-Pistofidis Romanos , Kodgule Rohan , Fulco Charles P. , Heilpern-Mallory Daniel , Nilsson Katarina , Dorfman David , Engreitz Jesse M. , Getz Gad , Pinello Luca , Ryan Russell J.H. , Ghobrial Irene M. 
Published: September 2024

Abstract
MYC deregulation occurs in the majority of multiple myeloma cases and is associated with progression and worse prognosis. Enhanced MYC expression occurs in about 70% of patients with multiple myeloma, but it is known to be driven by translocation or amplification events in only ∼40% of myelomas. Here, we used CRISPR interference to uncover an epigenetic mechanism of MYC regulation whereby increased accessibility of a plasma cell-type–specific enhancer leads to increased MYC expression. This native enhancer activity was not associated with enhancer hijacking events but led to specific binding of cMAF, IRF4, and SPIB transcription factors that activated MYC expression in the absence of known genetic aberrations. In addition, focal amplification was another mechanism of activation of this enhancer in approximately 3.4% of patients with multiple myeloma. Together, these findings define an epigenetic mechanism of MYC deregulation in multiple myeloma beyond known translocations or amplifications and point to the importance of noncoding regulatory elements and their associated transcription factor networks as drivers of multiple myeloma progression.
Significance: The discovery of a native developmental enhancer that sustains the expression of MYC in a subset of myelomas could help identify predictive biomarkers and therapeutic targets to improve the outcomes of patients with multiple myeloma.
Abstract A001: Health expenditure trajectory and gastric cancer incidence in the National Health Insurance Senior Cohort: A nested case-control study
Authors: Lee Minjee , Yoo Ki-Bong , Lee Woo-Ri 
Published: September 2024

Abstract
Background: Gastric cancer is the fourth most common cancer and highly prevalent in South Korea. Given its prolonged disease progression, understanding the impact of health expenditure patterns over time is crucial. This nested case-control study aimed to identify the association between health expenditure trajectory and incidence of gastric cancer. Methods: Data from the National Health Insurance Service Senior Cohort of South Korea were used. Individuals diagnosed with gastric cancer (N = 14,873) were matched to a non-diagnosed group (N = 44,619) in a 1:3 ratio using a nested case-control design. A latent class trajectory analysis was performed to identify the patterns of health expenditure among the matched participants. Furthermore, conditional logistic regression analysis was conducted to examine the relationship between healthcare expenditure trajectories and gastric cancer incidence. Results: Seven distinct health expenditure trajectories over a 5-year period were identified: consistently lowest (13.9%), rapidly increasing (6.4%), gradually increasing (14.1%), consistently second-highest (22.1%), middle-low (17.8%), gradually decreasing (12.8%), and consistently highest (12.9%). Compared to the Middle-low group, individuals in the rapidly increasing (OR = 2.07; 95% confidence interval [CI], 1.90–2.25), consistently lowest (OR = 1.43; 95% CI, 1.33–1.55), gradually increasing (OR = 1.23; 95% CI, 1.15–1.32), and consistently highest (OR = 1.08; 95% CI, 1.01–1.17) groups exhibited a higher risk of developing gastric cancer. Conclusion: Our findings emphasize the importance of monitoring health expenditures to prevent gastric cancer. The categorization of health expenditure by trajectories allowed the identification of specific risk groups that may be targeted by appropriate interventions.
Citation Format: Minjee Lee, Ki-Bong Yoo, Woo-Ri Lee. Health expenditure trajectory and gastric cancer incidence in the National Health Insurance Senior Cohort: A nested case-control study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A001.
Abstract A022: Glycemic control and risk of prostate cancer morality in Veterans with diabetes
Authors: Marrone Michael , Bishu Kinfe , Batten Macelyn , Gebregziabher Mulugeta 
Published: September 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR013) of the Conference Program/Proceedings.
Citation Format: Michael Marrone, Kinfe Bishu, Macelyn Batten, Mulugeta Gebregziabher. Glycemic control and risk of prostate cancer morality in Veterans with diabetes [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A022.
Abstract A082: Contribution of health insurance to racial and ethnic disparities in advanced stage diagnosis of 10 cancers
Authors: Choudhury Parichoy Pal , Sineshaw Helmneh M. , Freedman Rachel A. , Halpern Michael T. , Nogueira Leticia , Jemal Ahmedin , Islami Farhad 
Published: September 2024

Abstract
For many cancer sites, it is unclear to what extent differences in health insurance coverage contribute to racial and ethnic disparities in stage III-IV diagnoses. Using the National Cancer Database (1,893,026 patients aged 18-64 years, diagnosed between 2013-2019), we investigated a potential mediating role of health insurance (privately insured vs. uninsured) in explaining racial and ethnic disparities in stage at diagnosis of 10 cancers (i.e., breast, prostate, colorectal, lung, cervical, uterine, bladder, head and neck, skin melanoma), detectable early through screening, physical examination, or clinical symptoms. The analyses provided evidence of mediation of non-Hispanic Black vs. White disparities in eight cancers (range of proportions mediated: 4.5%-29.1%); Hispanic vs. non-Hispanic White disparities in six cancers (13.2%- 68.8%); non-Hispanic Asian/Pacific Islander vs. White disparities in three cancers (5.8%- 11.3%). To summarize, health insurance accounts for a considerable proportion of the racial and ethnic disparities in stage III-IV diagnoses across a wide range of cancers.
Citation Format: Parichoy Pal Choudhury, Helmneh M. Sineshaw, Rachel A. Freedman, Michael T. Halpern, Leticia Nogueira, Ahmedin Jemal, Farhad Islami. Contribution of health insurance to racial and ethnic disparities in advanced stage diagnosis of 10 cancers [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A082.