bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deficient GATA6–CXCR7 signaling leads to bicuspid aortic valve
Authors: Piñeiro-Sabarís Rebeca , MacGrogan Donal , de la Pompa José Luis 
Published: September 2024

ABSTRACT
The cardiac outflow tract (OFT) transiently links the ventricles to the aortic sac and forms the arterial valves. Abnormalities in these valves, such as bicuspid aortic valve (BAV), are common congenital anomalies. GATA6-inactivating variants cause cardiac OFT defects and BAV, but their mechanisms are unclear. We generated Gata6STOP/+ mice using CRISPR-Cas9, which show highly penetrant BAV (70%) and membranous ventricular septal defects (43%). These mice exhibited decreased proliferation and increased ISL1-positive progenitor cells in the OFT, indicating abnormal cardiovascular differentiation. Gata6 deletion with the Mef2cCre driver line recapitulated Gata6STOP/+ phenotypes, indicating a cell-autonomous role for Gata6 in the second heart field. Gata6STOP/+ mice showed reduced OFT length and caliber, associated with deficient cardiac neural crest cell contribution, which may cause valvulo-septal defects. RNA-sequencing analysis showed depletion in pathways related to cell proliferation and migration, highlighting Cxcr7 (also known as Ackr3) as a candidate gene. Reduced mesenchymal cell migration and invasion were observed in Gata6STOP/+ OFT tissue. CXCR7 agonists reduced mesenchymal cell migration and increased invasion in wild-type but not in Gata6STOP/+ explants, indicating the GATA6-dependent role of CXCR7 in OFT development and its potential link to BAV.
The venom of Habrobracon hebetor induces alterations in host metabolism
Authors: Kryukova Natalia A. , Yanshole Lyudmila V. , Zelentsova Ekaterina A. , Tsentalovich Yuri P. , Chertkova Ekaterina A. , Alekseev Alexander A. , Glupov Victor V. 
Published: September 2024

ABSTRACT
The ability of parasitic wasps to manipulate a host's metabolism is under active investigation. Components of venom play a major role in this process. In the present work, we studied the effect of the venom of the ectoparasitic wasp Habrobracon hebetor on the metabolism of the greater wax moth host (Galleria mellonella). We identified and quantified 45 metabolites in the lymph (cell-free hemolymph) of wax moth larvae on the second day after H. hebetor venom injection, using NMR spectroscopy and liquid chromatography coupled with mass spectrometry. These metabolites included 22 amino acids, nine products of lipid metabolism (sugars, amines and alcohols) and four metabolic intermediates related to nitrogenous bases, nucleotides and nucleosides. An analysis of the larvae metabolome suggested that the venom causes suppression of the tricarboxylic acid cycle, an increase in the number of free amino acids in the lymph, an increase in the concentration of trehalose in the lymph simultaneously with a decrease in the amount of glucose, and destructive processes in the fat body tissue. Thus, this parasitoid venom not only immobilizes the prey but also modulates its metabolism, thereby providing optimal conditions for the development of larvae.
Supplying Cash-Constrained Retailers: Understanding Shopkeeper Behavior at the Bottom of the Pyramid
Authors: Villa Sebastián , Escamilla Rafael , Fransoo Jan C. 
Published: September 2024

Problem definition: As the largest retail channel in the world, nanostores are the source of income for millions of shopkeepers in developing countries. Being cash constrained, nanostore shopkeepers face the challenge of deciding how much of their available cash to retain to support their families and how much to invest in acquiring products from their suppliers, who visit the nanostore with different frequencies and offer products with different margins. We study how shopkeepers deal with this challenge while seeking to make their nanostores financially sustainable. Methodology/results: We conduct an empirical study to explain how suppliers’ visit frequency influences shopkeepers’ ordering behavior. The study integrates more than 29 million orders placed with a multinational manufacturer. Results show that visit frequency adjustments by the supplier cause nanostores to experience a significant discontinuity in their orders such that reduced order frequency leads to significantly lower orders per unit of time. Building on this insight, we ran two experimental studies that make use of theoretical benchmarks to explore how shopkeepers’ ordering decisions are influenced by supplier visit frequency, product margin, and shopkeepers’ cash constraints. We analyze how and when shopkeepers deviate from the theoretical benchmarks and show how the available budget moderates the relationship between suppliers’ visit frequencies and shopkeepers’ order volumes, normalized by unit of time. Our results give support to the theory of diversification bias and show how this bias might bring additional benefits to suppliers offering low-margin products. Finally, we propose a behavioral model that explains how shopkeepers’ decisions might be driven by their preference toward inventory (i.e., leftover versus shortage aversion) and toward cash (i.e., liquidity preferences). Managerial implications: Our findings suggest that suppliers should deploy high-frequency visits to cash-constrained nanostores regardless of the margin that their products provide for shopkeepers. For low-margin suppliers, this mitigates shopkeepers’ tendencies to reduce the order volume per unit of time following a visit frequency decrease. For high-margin suppliers, high-frequency visits mitigate shopkeepers’ overdiversification bias and liquidity preference. Financial and digital schemes that reduce the need for high-frequency visits may lead to substantial efficiency gains. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0362 .
Educação alimentar e nutricional como prática emancipatória: por uma práxis popular e engajada
Authors: Marinho Viviane , De Sá Brito Fernanda Ribeiro dos Santos 
Published: September 2024

Este ensaio teórico visou trazer uma reflexão crítica sobre as aproximações entre as ideias de bell hooks e Paulo Freire em contribuição para a construção de uma Educação Alimentar e Nutricional (EAN) popular e engajada. A metodologia adotada foi a análise das obras desses autores, buscando compreender suas interseções e suas especificidades, sem a pretensão de esgotá-las. A pedagogia engajada proposta por hooks, aliada à pedagogia libertadora de Freire, buscam transformar não só a educação, mas a sociedade, tendo os sujeitos como protagonistas de seu próprio processo de aprendizagem e emancipação. Essas abordagens, ao serem incorporadas na EAN, podem ser promotoras de uma alimentação mais saudável, levando em consideração as questões de raça, gênero, cultura e poder presentes nas desigualdades alimentares nos mais diversos territórios. A EAN popular e engajada também se relaciona com a promoção da segurança alimentar e nutricional, respeitando a diversidade cultural e fomentando a participação política das pessoas e sua autonomia no processo de tomada de decisões relacionadas à alimentação e à saúde. Além disso, a formação de profissionais de saúde comprometidos com essa abordagem é fundamental para promover mudanças significativas nos paradigmas educacionais e na compreensão de lacunas importantes existentes na formação dos profissionais de saúde, no que se refere aos conteúdos do campo das ciências sociais e humanas. No contexto atual, marcado pelo fortalecimento do agronegócio e pela perda da diversidade alimentar, a EAN popular e engajada se mostra como um caminho para defender as culturas alimentares, lutar pela soberania alimentar e por uma alimentação mais diversa e sustentável.
Developing an ensemble machine learning study: Insights from a multi-center proof-of-concept study
Authors: Fanizzi Annarita , Fadda Federico , Maddalo Michele , Saponaro Sara , Lorenzon Leda , Ubaldi Leonardo , Lambri Nicola , Giuliano Alessia , Loi Emiliano , Signoriello Michele , Branchini Marco , Belmonte Gina , Giannelli Marco , Mancosu Pietro , Talamonti Cinzia , Iori Mauro , Tangaro Sabina , Avanzo Michele , Massafra Raffaella 
Published: September 2024

Background
To address the numerous unmeet clinical needs, in recent years several Machine Learning models applied to medical images and clinical data have been introduced and developed. Even when they achieve encouraging results, they lack evolutionary progression, thus perpetuating their status as autonomous entities. We postulated that different algorithms which have been proposed in the literature to address the same diagnostic task, can be aggregated to enhance classification performance. We suggested a proof of concept to define an ensemble approach useful for integrating different algorithms proposed to solve the same clinical task.

Methods
The proposed approach was developed starting from a public database consisting of radiomic features extracted from CT images relating to 535 patients suffering from lung cancer. Seven algorithms were trained independently by participants in the AI4MP working group on Artificial Intelligence of the Italian Association of Physics in Medicine to discriminate metastatic from non-metastatic patients. The classification scores generated by these algorithms are used to train SVM classifier. The Explainable Artificial Intelligence approach is applied to the final model. The ensemble model was validated following an 80–20 hold-out and leave-one-out scheme on the training set.

Results
Compared to individual algorithms, a more accurate result was achieved. On the independent test the ensemble model achieved an accuracy of 0.78, a F1-score of 0.57 and a log-loss of 0.49. Shapley values representing the contribution of each algorithm to the final classification result of the ensemble model were calculated. This information represents an added value for the end user useful for evaluating the appropriateness of the classification result on a particular case. It also allows us to evaluate on a global level which methodological approaches of the individual algorithms are likely to have the most impact.

Conclusion
Our proposal represents an innovative approach useful for integrating different algorithms that populate the literature and which lays the foundations for future evaluations in broader application scenarios.
Collaborative Governance on Energy Management Online Reporting According To Energy Conservation Policy
Authors: Windaru Akim , Kumorotomo Wahyudi , Pitoyo Agus Joko 
Published: September 2024

<p>Energy savings in Indonesia are still far from the expected target of only around 79,358 GWh/141,220 GWh. The achievement is based on online reporting of energy management by industry according to government regulation No. 70 of 2009 which is reported regularly every year. This is done by the government as support in reducing the impact of climate change that occurs today. The qualitative method used in this study was a collaborative governance process approach between the government and industry with a collaborative governance cycle that occurs, is then analyzed, and conclusions drawn. The research results obtained include difficulties in identifying industries because there are still differences in authority within different government agencies. There are still 30% of industries that meet the requirements but have not done online energy management reporting including the fulfillment of all energy management activities that must be carried out. Articles related to incentives and disincentives that have not been fully implemented by the government. Collaborative governance is very important to be applied in the division of tasks, functions, and roles of each party involved. So that all can run according to their rights and responsibilities so that the achievement of future energy saving targets can be achieved. </p>
Una antología reúne múltiples voces de poetas uruguayas
Authors: Puppo María Lucía 
Published: September 2024

Se trata de una reseña de
Flores raras: [escondido país]. Poesía de mujeres uruguayas.
Silvia Guerra y Jesse Lee Kercheval (compilación y edición), Prólogo de Lucía Delbene, Epílogo de María Rosa Olivera-Williams. Montevideo: Yaugurú-La madre del borrego, 2023, 448 páginas.
Myth and Cyber: A Study of the Narrative and Visual Language of Chinese Cyberpunk Anime Films
Authors: Wang Xiaoya , Yuan Jinbo 
Published: September 2024

Abstract
The cyberpunk genre started a new trend in Chinese anime movies after 2020, represented by the hugely commercially successful New Gods: Nezha Reborn (2021). Unlike Western cyberpunk, which focuses on portraying the future as a subcategory of science fiction, Chinese cyberpunk anime chooses to look back, fusing ancient myths with cyborgs, which is called myth-cyberpunk, reconstructing traditional Chinese culture, and broadening the boundaries of cyberpunk. This paper focuses on spatial construction and characterization in Chinese cyberpunk anime films. It traces the influence of Western cyberculture on Chinese animation and the uniqueness and local innovation of the Chinese side. Importantly, it examines the role of audience participation in the processes of cultural encoding and decoding, as proposed by Stuart Hall, to understand the dynamics behind the growing popularity of cyber animation in China. This paper aims to interpret the evolution of the cyberpunk style in Chinese animations, its reception, and its deeper societal motivations, offering insights into the unique allure of Chinese cyberpunk anime within the contemporary socio-cultural context.
Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of Pandanus odoratissimus leaves
Authors: Kumar Satyender , Kumar Dinesh , Sindhu Rakesh K. , Seema  , Devi Manisha , Sagar Sneha 
Published: September 2024

Abstract

Objectives
The purpose of this study was to explore the molecular docking characteristics and antifertility impacts of petroleum ether extract (PEEPO) and chloroform (CHEPO) derived from Pandanus odoratissimus (PO) leaves.

Methods
TriposSybyl-X 2.1 for molecular docking and Swiss ADME for ADME predictions were used. Antifertility activity was determined by using two in vivo animal models, with a focus on estrogenic/antiestrogenic activity and anti-implantation effects.

Results
The findings showed that at different doses (100, 200, and 400 mg/kg), PEEPO had more anti-implantation effect than CHEPO. After taking either extract orally for up to 4,000 mg/kg, no acute toxicity was found. Furthermore, both extracts substantially raised blood oestrogen levels while lowering serum cholesterol and LDL levels, improving their antiimplantation and estrogenic activities, whether given alone or in combination with ethinyl estradiol. Molecular docking scores suggested strong interactions between phytochemicals in the extracts and estrogen receptors. ADME studies highlighted four phytochemicals present in PO leaves, showing high gastrointestinal absorption, blood-brain barrier permeability, and negative Log Kp values, indicating their potential as antifertility agents.

Conclusions
The phytochemicals in both PEEPO and CHEPO demonstrated promising antifertility potential and interactions with estrogen receptors. Isolation of these phytochemicals could lead to the development of effective herbal antifertility formulations.
Predation of Natalus macrourus (Chiroptera: Natalidae) by Trachops cirrhosus (Chiroptera: Phyllostomidae) in a ferriferous Brazilian Amazon cave
Authors: Genelhú Sebastião Maximiano Corrêa , Marcos Marcelo Henrique , Prous Xavier , Ribeiro Mariane , Pietrobon Thadeu 
Published: September 2024

Abstract

Trachops cirrhosus bats are especially notable for feeding on various types of preys throughout its range, including other bat species. Here we report predation events of T. cirrhosus on Natalus macrourus, a new bat species among a wide range of prey.
Effect of magnesium doping on NiO hole injection layer in quantum dot light-emitting diodes
Authors: Lee Nayoon , Vo Van Khoe , Lim Hyo-Jun , Jin Sunwoo , Dang Thi Huong Thao , Jang Heewon , Choi Dayoung , Lee Joon-Hyung , Jeong Byoung-Seong , Heo Young-Woo 
Published: September 2024

Abstract
This study reports on the fabrication of quantum dot light-emitting diodes (QLEDs) with an ITO/Ni1−x
Mg
x
O/SAM/TFB/QDs/ZnMgO/Al structure and investigates the effects of various Mg doping concentrations in NiO on device performance. By doping Mg into the inorganic hole-injection layer NiO (Ni1−x
Mg
x
O), we improved the band alignment with the hole-injection layer through band tuning, which enhanced charge balance. Optimal Mg doping ratios, particularly a Ni0.9Mg0.1O composition, have demonstrated superior device functionality, underscoring the need for fine-tuned doping levels. Further enhancements were achieved through surface treatments of Ni0.9Mg0.1O with UV-Ozone (UVO) and thermal annealing (TA) of the ZnMgO electron transport layer. Consequently, by optimizing Mg-doped NiO in QLED devices, we achieved a maximum external quantum efficiency of 8.38 %, a brightness of 66,677 cd/m2, and a current efficiency of 35.31 cd/A, indicating improved performance. The integration of Mg-doped NiO into the QLED structure resulted in a device with superior charge balance and overall performance, which is a promising direction for future QLED display technologies.
On the “How” and the “Why”: Nietzsche on Happiness and the Meaningful Life
Authors: Faustino Marta 
Published: September 2024

Abstract
Nietzsche is commonly interpreted as strongly rejecting and even despising any possible conception (or pursuit) of happiness. And yet, one of the most pervasive topics in Nietzsche’s work is the problem of human suffering, the pursuit of meaning (or purpose) in life, and the possibility of a joyful or affirmative disposition toward existence. In this article, I argue that Nietzsche’s criticism of common conceptions of happiness should be seen as a redefinition, rather than a rejection, of the notion of human happiness, with important implications for contemporary discussions on the topic. I start by addressing three of the main contemporary theories of happiness from a Nietzschean perspective, underlining both the points of convergence and the points of divergence between Nietzsche and each of these accounts. I then gather the conclusions of the previous section, add Nietzsche’s positive claims on happiness and the meaningful life, and sketch what might be called a Nietzschean theory of happiness. Finally, I situate Nietzsche’s position in the contemporary debate on the topic and outline what I take to be his most important contributions to current discussions on happiness, meaning, and well-being in human life.
Speed and Reliability of Touch vs Mouse Inputs in Visual Foraging
Authors: Sauter Marian 
Published: September 2024

Abstract
Traditional visual attention research predominantly employs a visual search paradigm focused on identifying a single target within a scene. This approach, however, may not fully encapsulate the complexities of natural environmental interactions, which often involve multiple decisions and actions. Addressing this gap, recent advancements have introduced touch-screen-based foraging tasks, where participants are required to identify and cancel multiple targets through tactile interaction. Despite its intuitive appeal, the widespread adoption of this methodology has been limited. This article explores the computer mouse as a viable alternative for target cancellation in such foraging tasks. We conducted an experiment comparing search performance between touch and mouse inputs in a visual foraging task, requiring participants to locate and interact with a known target multiple times under various search types. Our findings indicate that while mouse responses are marginally slower, the variance in response times is consistent across both input modalities. Contrary to expectations, we observed no significant disadvantages when employing the mouse as opposed to touch screens. The results suggest that the computer mouse is a competent and underutilized tool in visual attention research, offering a comparable and effective alternative to touch-based devices for complex search tasks.
Geopolitics and geospatial strategies: the rise of regulatory supply chain controls for semiconductor GPN in Japan, South Korea and Taiwan
Authors: Aoyama Yuko , Song Eunyeong , Wang Shan-yu 
Published: September 2024

Abstract
In this article, we present an analysis of how East Asian states (specifically, Japan, South Korea and Taiwan) are adapting to the emerging geopolitical contexts of the ‘great powers competition’ between the United States and China. To the extent that the previous literature on GPN/GVC governance included the state as one of the extra-firm actors, geopolitics has not been explicitly dealt with in its role in shaping GPN/GVC governance. We build on the existing research on GPN/GVC governance and propose a shift in perspective, from one of cost-driven to diplomacy-driven governance. Taking the case of the semiconductor industry, we conduct an analysis of native language sources and examine how regulatory supply chain controls are shaping East Asian industrial and trade policies. Specifically, we focus on how East Asian states are negotiating their dependence on the world’s two largest markets, the United States and China, and developing new policy strategies in order to navigate the dual hegemony. The analysis reveals that, while varying strategies are adopted, multilateral alliances of the states are gaining prominence in GPN/GVC governance. We conclude that a more state-centric analysis of GPN/GVC is in order.
A family enterprise: The Shonubis of Ikorodu, 1919–1949
Authors: Boge Faruq Idowu 
Published: September 2024

Abstract
The impact of the Shonubi family on the economic and commercial interrelations between the Ikorodu district and Lagos during the colonial period is indelible. Two prominent personalities, a mother and her son, distinguished themselves in trade, commerce, agro-allied and the transportation sub-sectors of the economy by harnessing indigenous entrepreneurial ingenuity. The mother, Patricia Efun, was not only the «king of women» in the traditional political realm, but she was also indeed a leader in other dimensions. The son, Joseph Shonubi (popularly known as Owolowo), took the opportunity of his mercantile background to make a mark in the business world. However, apart from the personal and family benefits, their entrepreneurial exploits contributed to laying the foundation of post-colonial economic developments in Ikorodu and Lagos. This paper highlights the connections between family wealth and entrepreneurial exploits in the colonial Ikorodu district of the Lagos Colony. It is based on archival materials, oral interviews and newspaper reportage among others.