bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract No.: ABS0369: Comparison of norepinephrine and terlipressin versus norepinephrine alone for management of septic shock: A randomised control study.
Authors: Sahoo Pallavi 
Published: September 2024

Background and Aims:
Terlipressin, a V1 receptor-selective analogue of vasopressin, can produce potent vasoconstriction of blood vessels and can reduce the dose of norepinephrine required for maintaining the mean arterial pressure (MAP) and organ perfusion in septic shock, thus avoiding its side effects.

Methods:
In this prospective, randomised control trial, 50 adult patients with septic shock were divided into two groups. Group 1 received a combination of terlipressin 0.02 µg/kg/min (fixed dose) infusion and noradrenaline 0.01–3.0 µg/kg/min infusion intravenously. Group 2 received intravenous noradrenaline 0.01–3.0 µg/kg/min infusion alone. Noradrenaline in both groups was targeted to achieve an MAP of 65–70 mm of Hg. The data collected were the dose of noradrenaline required to maintain an MAP of above 65 mm of Hg, urine output, serum lactate, procalcitonin level, C-Reactive protein, sequential organ failure assessment score (SOFA) score, total duration of the vasopressor support, and incidence of adverse effects.

Results:
The noradrenaline dose in group 1 versus group 2 at 12 hours was found to be 0.141 ± 0.067 vs 0.374 ± 0.096 µg/kg/min (p=<0.005). The blood lactate concentration was significantly lower, and the urine output was higher in group 1 than in group 2 (p=<0.005). Group 1 had a significantly greater reduction in SOFA score in 12 hours than group 2. However, there was no difference in the mortality between the two groups during their intensive care unit stay.

Conclusion:
A low-dose continuous infusion of terlipressin along with norepinephrine could help attain better organ perfusion and early resuscitation goals for management of patients with septic shock without causing the side effects related to catecholamines.
Abstract No.: ABS0480: A retrospective study observing outcome following posterior fossa craniotomy in patients with sitting position
Authors: Mathur Ashish 
Published: September 2024

Background & Aims:
To assess the outcome following posterior fossa craniotomy in sitting position with respect to haemodynamic changes as well as intra and post operative complications

Methods:
The study involved reviewing the case records of 100 adult patients who underwent posterior fossa craniotomy in sitting position under general anaesthesia. In these patients, induction was done with thiopentone sodium 5mg/kg. Neuromuscular blockade was achieved with vecuronium bromide 0.1mg/kg to facilitate intubation. Radial arterial line was inserted preferably in left hand side for invasive blood pressure monitoring. Patients were positioned in sitting position slowly over 20-30 minutes. Vital parameters of the patients were monitored during and after positioning. Patients were observed in ICU for first 48 hours for neurological status, cardiovascular status, respiratory and surgical complications.

Results:
We found significant haemodynamic changes during and after sitting position which normalised after 2 hours of position. There were no perioperative cardiac events and neurological alteration. The incidence of venous air embolism was 2 % and it was not associated with any postoperative morbidity and mortality

Conclusion:
Present study concluded that the use of sitting position for patients undergoing posterior fossa surgery is safe.

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Abstract No. : ABS0510: Total intravenous anaesthesia (TIVA) with dexmedetomidine versus nalbuphine in combination with propofol in upperlimb orthopaedic closed manipulation procedure- a comparative study in a tertiary health care centre in Tripura.
Authors: DAS RUPAMAY 
Published: September 2024

Background &Aims:
The study was planned with the aim of generating comparison profile regarding effects of dexmedetomidine and nalbuphine in combination with propofol while providing more effective stability of intra-procedural haemodynamics and post procedural pain and sedation in upperlimb closed manipulation procedure.

Methods:
It was an observational analytical study with longitudinal design. The study duration was one and half years. Patients of either sex, normalbodymassindexand age between 20-60 years participatedas study population. 60 cases weredevided into two groups and coded as group D and group N. Both the groups received uniform premedication with Injodansertron 8mg I.V and Inj. omeprazole 40 mg I.V. Group D received Inj. propofol (1%) 1.5mg/kg plus Inj. dexmedetomidine 50 µg I.V bolus while group N received inj. propofol (1%) 1.5mg/kg plus Inj. nalbuphine 10mg I.V bolus prior to theprocedure.

Results:
Intra operative mean arterial pressure (MAP) and heart rate (HR) were significantly higher in group N than group D (p<0.05). No significant difference was recorded regarding respiratory rate and SpO2 in the two groups (p>0.05). Recovery time of orientation was significantly lower in group D (p<0.05). Post procedural perception of pain was significantly lower in group D (p<0.05). Post procedural sedation was lower in group D which was statistically significant (p<0.05).

Conclusion:
Dexmedetomidine is superior to nalbuphine in respect of more effective intra-procedural haemodynamic stability, recovery oforientation , pain control after procedure and control of sedation after procedure.
Abstract No. : ABS0544 : A prospective randomised study comparing computerised tomography guided neurolytic coeliac plexus block with oral analgesic therapy in the treatment of severe pain due to pancreatic cancer
Authors: Panchal Jay 
Published: September 2024

Background and Aims:
Neurolytic Coeliac Plexus block (NCPB) is a promising treatment modality apart from commonly practiced oral analgesic
Therapy (OAT) for pancreatic cancer pain. The aim was to compare the efficacy of NCPB with OAT in the treatment of severe pancreatic cancer pain.

Methods:
Forty four patients with severe upper abdominal pain (Visual Analogue Scale(VAS) >7/10) due to unresectable pancreatic cancer were allocated randomly and equally in either NCPB group or OAT group. Patients in NCPB group were treated with 99.99% ethanol as neurolytic agent for coeliac plexus block under Computerised Tomography (CT) guidance. OAT group patients were treated with morphine tablets orally. Patients’pain intensity and opioid analgesic consumption (Oral Morphine equivalent (OME)) were assessed at day 1, 7 and 28 after the intervention. Oral morphine tablets were started in the NCPB group when the patients had severe pain after the NCPB intervention.

Results:
Mean baseline VAS pain scores were 8.2 and 7.9 for NCPB group and OAT group, respectively. At day 1, 7 and 28, pain scores of NCPB group were significantly lower than that of OAT group (P<0.05), 1.4±0.7 versus 3.9±0.8, 1.7±0.6 versus 3.3±0.5 and 2.1±0.8 versus 3.0±0.7, respectively(table 1). At day 1, 7 and 28, OME (mg/day) values in NCPB group were significantly lower than in OAT group (P<0.05), 8.1±0.2 versus 39.5±0.7, 12.2±0.8 versus 48.3±0.4 and 14.6±0.5 versus 57.1±0.8, respectively (table 2).

Conclusion:
CT guided NCPB is an effective treatment modality for controlling severe upper abdominal pain due to unresectable pancreatic cancer. Celiac plexus, block, pancreatic cancer

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Abstract No.: ABS0586: Is pressure control ventilation better than volume control in patients undergoing spine surgery in prone position?
Authors: RenuBala  
Published: September 2024

Background & Aims:
Optimisation of intraoperative ventilation is feasible nowadays due to availability of several new modes in anaesthesia workstations. Spine surgery in prone position leads to pulmonary and haemodynamic alterations. The present study aimed to compare PCV and VCV modes of ventilation in patients undergoing spine surgeries.

Methods:
After obtaining approval from institutional ethics committee the present, prospective, randomised study was conducted in 50 adult patient of either sex, ASA I or II undergoing thoracic or lumbar spine surgery in prone position. Standard anaesthesia protocols using Thiopentone, Fentanyl and Vecuroniun was followed. Patients in VCV group (n=25) were ventilated with volume control mode with TV = 7 ml/kg, PEEP=5cm H2O, I: E=1:2 and respiratory rate adjusted to keep Et CO2 between 35-40 mmHg and FiO2 =0.4. While in PCV mode (n=25) patients were ventilated with similar settings except PIP was adjusted to determine TV=7ml/kg. Draeger Primus workstation was used.

Results:
Demographic profile, duration of surgery, intraoperative dry and fluid consumption were comparable in two groups. Peak inspiratory pressure was higher in VCV (20 vs 18) and dynamics compliance was low in VCV (31.3 vs 35.93). Minute ventilation, EtCO2, dead space, O2 saturation was comparable in two groups though alveolar oxygenation was better in PCV. Diastolicblood pressure was low in VCV. Postoperative PFT decreased in both groups but were comparable.

Conclusion:
PCV is better than VCV in maintaining intraoperative respiratory mechanisms but whether they offer long term benefit require more studies comprising of larger sample sizes.

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Abstract No. : ABS0638: Comparison of transforaminal epidural injection vs trigger point injection for low back pain.
Authors: Bathia Ravi 
Published: September 2024

Background and Aims:
Lumbar transforaminal epidural steroid injection(TFESI) is a frequently used intervention for lumbar radiculitis but is associated with complications. Trigger-point therapy isa useful adjunct in the treatment of low-back pain. This study compared the efficacy and safety of transforaminal injection with trigger point injections(TPI) for chronic back pain.

Methods:
Clinical data of 1000 patients with back pain were searched retrospectively. All patients received conservative modalities of treatment which continued for a month Patients who did not respond to conservative were given interventional treatment. Data of 90 patients who were given TFESI [group E] and 90 patients who were given TPI[group T] were analysed and followed up to 6 months. Visual analogue scale(VAS) score and Oswestry disability index (ODI) score were evaluated beforeprocedure and at 1 month, 3 months and 6 months. VAS and ODI for all time intervals were analysed with student’s t-test. Proportions of complications between two groups were compared.

Results:
The VAS score in group E at one month(33±13.16),three months(25±16) and six months (16.14±16) was less than that the scores in group T at one month(40.6±14.16), three month(33±18) and six month(26±22)(figure 1). The difference of VAS and ODI between group E and T was statistically significant.

Conclusion:
TFESI is more effective than TPI. .However TPI can be added as a step-up procedure between conservative management and TFESI, in patients with low back pain.
Abstract No.: ABS0807 : Effects of intravenous Lignocaine infusion on Sevoflurane consumption in inhalation maintained anaesthesia by monitoring entropy: A randomised controlled study
Authors: V Deep 
Published: September 2024

Background & Aims:
The present study aimed to study the effect of intravenous Lignocaine infusion on Sevoflurane consumption required to maintain entropy between40 and 60 during anesthesia maintenance in humans. Pain scores using Numeric rating score (NRS) scale and incidence of post-operative nausea and vomiting were assessed postoperatively.

Methods:
The present study included 52 patients of either sex, of American Society of Anesthesiologists (ASA) grade I and II; aged between 18-70 years undergoing surgeries of >2 hours under general anaesthesia. Patients were randomly allocated into two groups using computer generated random number table into Lignocaine group, where lignocaine infusion was used and Control group, where equal volume of saline was infused. Anaesthesia regimens in both groups were standardised. Patient’s haemodynamics were monitored. Intraoperative Sevoflurane consumption (Value obtained from GE Avance CS2 machine) was noted at the end of surgery. Pain scores using NRS scale and postoperative nausea and vomiting incidence were assessed postoperatively.

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Results:
There was a statistically significant difference in hourly Sevoflurane consumption with reduced hourly consumption inLignocaine group, (P=0.03). There was no statistically significant difference in the total amount of sevoflurane consumption between the two groups, (p=0.52). The lignocaine group had lower pain score than control group 45min post extubation(P=0.04) and 1 day post surgery (P=0.01), with no significant difference in the incidence of post-operative nausea and vomiting.

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Conclusion:
Perioperative lignocaine infusion significantly reduces hourly Sevoflurane consumption in inhalation maintained anaesthesia. Perioperative lignocaine infusion causes significant reduction in pain scores but no difference in incidence of PONV. Lignocaine infusion is safe and further studies may provide a strong evidence for routine use of perioperative lignocaine.
Abstract No.: ABS0875: Utilisation of machine learning in predicting clinical outcome in COVID-19
Authors: Eadara Venkata Sandeep 
Published: September 2024

Background and Aims:
The goal of this study was to develop a deep-learning artificial intelligence algorithm to identify the top predictors amongst the large array of clinical variables at admission to predict the likelihood of mortality in coronavirus disease 19 (COVID-19) patients.

Methods:
Data such as complete blood count, RFT, serum electrolytes, liver function tests, interleukin-6 (IL-6), C-reactive protein, procalcitonin, ferritin, FiO2, mode of ventilation, age, sex, and co-morbidities were collected from 250 patients admitted to the ICU. The variables missing for more than 20% of the people were removed. Chi-Square and Pearson’s correlation coefficient were used to remove the clinical variables having less importance with respect to the probability of being discharged or mortality. The LightGBM model was used for classification. The data were split into train and test in the ratio of 0.8:0.2. This gave an output of survival and mortality probability.

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Results:
The model gave a result with an accuracy of 0.64, a precision of 0.73, a recall of 0.64, an F1 score of 0.66, and an area under the curve of 0.79. The model had a specificity of 66.6% and a sensitivity of 61.5%. Ferritin and IL-6 values were the top predictors of mortality.

Conclusion:
This approach has the potential to provide frontline physicians with a simple and objective tool to stratify patients based on risks so that they can triage COVID-19 patients more effectively in time-sensitive, stressful, and potentially resource-constrained environments.
Abstract No.: ABS0888: BIS (Bispectral Index) The current tool for monitoring of unintended awareness and depth of anaesthesia
Authors: Kheskani Divya 
Published: September 2024

Background & Aims:
Awareness under general anaesthesia is an unpleasant phenomenon which often goes unnoticed and neglected. Numerous incidences of intraoperative awareness are not reported. Our aim was to evaluate intraoperative awareness during general anaesthesia and titrate amount of anaesthetic agents according toBispectral Index ( BIS).

Methods:
This randomised, prospective comparative study was conducted in 100 adult patients, randomly divided equally in to 2 groups: BIS and NON BIS. After obtaining written informed consent,patients belonging to American Society of Anesthesiologists (ASA) grade 1and 2, aged 20-60 years, weighing 40-75 kg posted for elective surgical procedures in various specialties under general anaesthesia were included. Patients with ASA 3 & 4, psychiatric illness on medication, language barrier, pregnancy or known allergy to propofol were excluded. Postoperatively intraoperative awareness was assessed by modified form of Brice questionnaire at various time intervals. Hemodynamic parameters were monitored and total propofol consumption was calculated.

Results:
Intra-operative awareness reported was 2% in BIS group and 8% in NON-BIS group. Total propofol consumption in BIS group was significantly less as compared to NON BIS group respectively 8.25Â±1.7 mg vs 11.15Â±2.5 mg (P value <0.0001).

Conclusion:
BIS serves as an excellent tool for awareness monitoring and titration of anaesthetic drugs perioperatively

AWARENESS IN BOTH GROUPS.

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Abstract No.: ABS1045: Ultrasonographic evaluation of the effect of positive end expiratory pressure andpulmonary recruitment maneuver on diaphragmatic functions in patients undergoing laparoscopic abdominal surgery
Authors: C Namratha 
Published: September 2024

Background & Aims:
Reports suggest diaphragmatic impairment after laparoscopic abdominal surgery by gas insufflation causes postoperativepulmonary dysfunction. Intraoperative PEEP, recruitment maneuver prevents lung atelectasis mitigating complications.
The aim was to evaluate effects of PEEP,pulmonary recruitment maneuver on diaphragmatic functions during pneumoperitoneum in patients undergoing laparoscopic surgeries

Methods:
After ethical committee clearance and patient consent, a randomised control trial conducted among 63 patients undergoing laparoscopic abdominal surgeries under GA. Patient belonging to ASA 1,2 and giving informed written consent were includedthose having severe systemic illness, BMI>30 were excluded. Patients undergoing laparoscopic abdominal surgery under GAwere randomized using computer generated numbers into three equal groups, A with zero PEEP, B with 5 PEEP, C withpulmonary recruitment maneuver. Perioperatively diaphragmatic excursion, intraoperatively peak inspiratory pressure, hemodynamic parameters (MAP, HR) and dynamic compliance of the lungs were measured. Mann Whitney U test were applied.

Results:
Mean diaphragmatic excursion in cm at baseline, after pneumoperitoneum, reverse Trendelenburg position, extubation, 6 h postoperatively in Group A (3.63+0.28,.040+18,3.08+0.008,2.88+0.34,3.56+0.33,) Group B (3.65+0.27,3.29+0.30,3.13+0.29,3.40+0.37,3.65+0.29), Group C (3.75+0.31,3.41+0.28,3.20+0.30,3.40+0.34,3.74+0.31), p value (0.743,0.742,0.000,0.000.0.000), Mean Peak inspiratory pressure in mmhg before and after applying PEEP, after pneumoperitoneum and reverse Trendelenburg in Group A (16.11+0.90,16.04+0.89,22.01+1.20,22.06+1.27) Group B (16.19+1.03,16.73+2.74,22.44+1.39,23.98+2.28), Group C (16.21+1.05,16.73+2.72,22.44+1.33,25.96+2.28), p value (0.236,<0.001,<0.001,0.001), Dynamic compliance was statistically significantly lower in Group A compared to Group B and Group C at all time points, although there is no statistical difference between B,C groups, values were higher in Group C throughout.

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Conclusion:
Application of PEEP is helpful for preserving diaphragmatic excursion during laparoscopic abdominal surgeries. In thepresent study pulmonary recruitment maneuver improved diaphragmatic excursion and dynamic compliance, although there was significant increase in peak inspiratory pressure compared to other groups.
Abstract No.: ABS1074 : Evaluation of efficacy of superficial cervical plexus block for surgeries in head and neck region: A comparative randomised control study
Authors: Patel Himani 
Published: September 2024

Background and Aims:
Superficial cervical plexus block can provide analgesia in head and neck surgeries. This study aimed to evaluate analgesic efficacy of superficial cervical plexus block (SCPB) in various head and neck surgeries, with the primary objectives of assessing time to first rescue analgesic, total dose of rescue analgesics in 24 hours, intraoperative analgesic requirement and associated perioperative complications.

Methods:
Sixty patients of American Society of Anesthesiologists physical class II,III (30 patients in each group) were included. Group A received general anaesthesia(GA) with systemic analgesia and group B received GA followed by SCPB with injection bupivacaine 0.25% 10ml on each side according to site of surgery. Visual analogue scale(VAS) scores, intra and postoperative analgesic requirement in 24 hours, time of first rescue analgesic demand and peri-operative complications were noted. All quantitative data were analysed by student-t test and qualitative data was analysed by chi-square test.

Results:
Time of first rescue analgesia was earlier and intraoperative fentanyl requirement and postoperative total rescue analgesic requirement were higher in group A (32.33+_38.39, 38.33+_12.61, 2566.667 + _504.006) than group B(1092+_396.55 minutes, 10.66+_13.11, 833.33+_874.28 ) with p value <0.001 (table 1,2). No significant complication was noted in any patient.

Conclusion:
SCPB provides better perioperative analgesia and decreases intraoperative as well as postoperative analgesic requirements and associated side effects with no significant perioperative complications in various head and neck surgeries.

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Abstract No.: ABS1288: A multicentric research study on correlation between covid 19 vaccination status and severity of disease
Authors: Patel Ankita 
Published: September 2024

Background & Aims:
To correlate the severity of coronavirus disease (COVID) with vaccination status in COVID 19 pandemics. The Primary Objective of the present study was to know occurrence of Post vaccination breakthrough infections in hospitalized patients and the Secondary Objective was to assess the severity of COVID-19 infection amongst vaccinated patients.

Methods:
The present study was a retrospective observational multicentric study performed on 325 covid positive patients admitted in High dependency units (HDUs) and Intensive care units (ICUs) and were either on Non rebreather mask (NRBM) or Bilevel positive airway pressure (Bipap) or invasive Ventilation. These patients were then divided as per severity of their symptoms into severe or non severe in correlation with their vaccination status. The study included covid positive as well as High resolution computed tomography (HRCT) thorax suggestive of covid ground glass appearance with age above 18 years and excluded patients who developed adverse reaction post vaccination, pediatric age group, pregnant and lactating females.

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Results:
Total 325 confirmed covid positive patients were studied. Statistical analysis was done with SPSS version 26 and data were analysed by Chi-square test & P value< 0.05 was considered as significant. Total duration of hospital stay was less in vaccinated patients compared to non vaccinated patients and also oxygen requirement was much less in vaccinated patients. The severity of covid infection was also less in vaccinated than amongst non vaccinated.

Conclusion:
Covid 19 vaccination is very effective in preventing severity of infection.