bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral and parasitic pathogen burden and the association with stroke in a population-based cohort
Authors: Pearce Brad D , Bracher Anna , Jones Jeffrey L , Kruszon-Moran Deanna 
Published: September 2017

Background Higher cumulative burden of viral and bacterial pathogens may increase the risk of stroke, but the contribution of parasitic infections in relation to cumulative pathogen burden and risk of stroke has rarely been examined. Aim To estimate the association of multiple persistent viral and parasitic infections with stroke in a representative sample of adults in the United States. Methods Serological evidence of prior infection was categorized as positive for 0–1, 2, 3, or 4–5 infections based on immunoglobulin G seropositivity to cytomegalovirus, hepatitis A virus, hepatitis B virus, Toxoplasma gondii, and Toxocara spp. in 13,904 respondents from the National Health and Nutrition Examination Survey III. Regression analysis was used to estimate the cross-sectional association between serological evidence of prior infection and history of stroke adjusting for demographic risk factors, and potential mediators of stroke. Results Age-adjusted models that included serological evidence of prior infection to cytomegalovirus, hepatitis A virus, hepatitis B virus, Toxoplasma gondii, and Toxocara spp. showed that adults in the highest serological evidence of prior infection category (4–5 infections) had a higher prevalence of stroke (5.50%, 95% confidence interval 2.44–10.46%) than those in the lowest serological evidence of prior infection categories (1.49%, 95% confidence interval 1.01–2.11%), and a trend test suggested a graded association between serological evidence of prior infection and stroke ( p = 0.02). In multivariable logistic regression models, the positive association of serological evidence of prior infection with stroke prevalence remained significant after adjustment for other significant risk factors (odds ratio = 1.4, p = 0.01) but was only significant among those aged 20–59 (odds ratio = 2.0, p = 0.005) and not among those aged 60–69 ( p = 0.78) or 70 and older ( p = 0.43). Conclusion We found support for a connection between serological evidence of prior infection to cytomegalovirus, hepatitis A virus, hepatitis B virus, Toxoplasma gondii, and Toxocara spp. and stroke among those aged 20–59. There may be a need to consider common parasitic infections in addition to viral and bacterial pathogens when calculating serological evidence of prior infection in relation to cerebrovascular disease.
Hemispheric asymmetries in dorsal language pathway white-matter tracts: A magnetic resonance imaging tractography and functional magnetic resonance imaging study
Authors: Silva Guilherme , Citterio Alberto 
Published: September 2017

Introduction Previous studies have shown that the arcuate fasciculus has a leftward asymmetry in right-handers that could be correlated with the language lateralisation defined by functional magnetic resonance imaging. Nonetheless, information about the asymmetry of the other fibres that constitute the dorsal language pathway is scarce. Objectives This study investigated the asymmetry of the white-matter tracts involved in the dorsal language pathway through the diffusion tensor imaging (DTI) technique, in relation to language hemispheric dominance determined by task-dependent functional magnetic resonance imaging (fMRI). Methods We selected 11 patients (10 right-handed) who had been studied with task-dependent fMRI for language areas and DTI and who had no language impairment or structural abnormalities that could compromise magnetic resonance tractography of the fibres involved in the dorsal language pathway. Laterality indices (LI) for fMRI and for the volumes of each tract were calculated. Results In fMRI, all the right-handers had left hemispheric lateralisation, and the ambidextrous subject presented right hemispheric dominance. The arcuate fasciculus LI was strongly correlated with fMRI LI ( r = 0.739, p = 0.009), presenting the same lateralisation of fMRI in seven subjects (including the right hemispheric dominant). It was not asymmetric in three cases and had opposite lateralisation in one case. The other tracts presented predominance for rightward lateralisation, especially superior longitudinal fasciculus (SLF) II/III (nine subjects), but their LI did not correlate (directly or inversely) with fMRI LI. Conclusion The fibres that constitute the dorsal language pathway have an asymmetric distribution in the cerebral hemispheres. Only the asymmetry of the arcuate fasciculus is correlated with fMRI language lateralisation.
Effects of Exercise on Sport Concussion Assessment Tool–Third Edition Performance in Professional Athletes
Authors: Lee Jin H. , Howell David R. , Meehan William P. , Iverson Grant L. , Gardner Andrew J. 
Published: September 2017

Background: The Sport Concussion Assessment Tool–Third Edition (SCAT3) is currently considered the standard sideline assessment for concussions. In-game exercise, however, may affect SCAT3 performance and the diagnosis of concussions. Purpose: To examine the influence of exercise on SCAT3 performance in professional male athletes. Study Design: Controlled laboratory study. Methods: We examined the SCAT3 performance of 82 professional male athletes under 2 conditions: at rest and after exercise. Results: Athletes reported significantly fewer total symptoms (mean, 1.0 ± 1.5 vs 1.6 ± 2.3 total symptoms, respectively; P = .008; Cohen d = 0.34), committed significantly fewer errors on the modified Balance Error Scoring System (mean, 3.5 ± 3.5 vs 4.6 ± 4.1 errors, respectively; P = .017; d = 0.31), and required significantly less time to complete the tandem gait test (mean, 9.5 ± 1.4 vs 9.9 ± 1.7 seconds, respectively; P = .02; d = 0.30) during the at-rest condition compared with the postexercise condition. Conclusion: The interpretation of in-game (sideline) SCAT3 results should consider the effects of postexercise fatigue levels on an athlete’s performance, particularly if preseason baseline data have been collected when the athlete was well rested. Clinical Relevance: Exercise appears to affect symptom burden and physical abilities, such as balance and tandem gait, more so than the cognitive components of the SCAT3.
A Systematic Review Examining the Oral Health Status of Persons with Dementia
Authors: Foley N.C. , Affoo R.H. , Siqueira W.L. , Martin R.E. 
Published: September 2017

While the oral health of persons with dementia has been shown to be poor, no systematic reviews have been published that examined the topic in depth, including participants with dementia representing the full spectrum of disease severity, and evaluating a broad scope of oral health assessments. The aim of this study was to conduct a current literature review to fill this gap in knowledge. A systematic search of 5 databases (CINAHL, PubMed, EMBASE, Scopus, and ISI Web of Science) was conducted to identify all relevant studies published up to May 2016. There were no exclusions related to study type, severity of dementia, dentate status, or living arrangements. Results were reported descriptively and summarized. Meta-analyses were performed where possible and reported as mean difference (MD) or standardized mean difference (SMD), with a 95% confidence interval (CI). Twenty-eight studies were identified. Assessments were conducted of tooth status, active dental caries, hygiene (plaque/calculus) of natural and artificial teeth, periodontal diseases, denture status (retention, stability, denture-related mucosal lesions), and oral health–related quality of life. Across all evaluations, persons with dementia generally had scores/results suggestive of poor oral health. In meta-analyses, compared with persons without dementia, those with dementia had a significantly fewer number of teeth (MD, −1.52; 95% CI, −0.2.52 to −0.52; P = 0.003; n = 13 studies), more carious teeth (SMD, 0.29; 95% CI, 0.03 to 0.48; P = 0.028; n = 9), significantly worse oral hygiene evaluated using a broad range of assessment tools (SMD, 0.88; 95% CI, 0.57 to 1.19, P < 0.0001; n = 7), and significantly poorer periodontal health (SMD, 0.38; 95% CI, 0.06 to 0.70; P = 0.02; n = 6 studies). The oral health status of persons with mild to severe forms of dementia, who were living in both the community and residential care facilities, was found to be poor across a broad range of dental assessments. Knowledge Transfer Statement: The results of this study define the scope of oral issues and quantify the degree of impairment in individuals with dementia, evaluated using a variety of oral health measures. The results revealed that poor oral health is associated with dementia.
Clinical impact of BAALC expression in high-risk acute promyelocytic leukemia
Authors: Lucena-Araujo Antonio R. , Pereira-Martins Diego A. , Koury Luisa C. , Franca-Neto Pedro L. , Coelho-Silva Juan L. , de Deus Wagatsuma Virginia M. , Melo Raul A. M. , Bittencourt Rosane , Pagnano Katia , Pasquini Ricardo , Chiattone Carlos S. , Fagundes Evandro M. , Chauffaille Maria de Lourdes , Schrier Stanley L. , Tallman Martin S. , Ribeiro Raul C. , Grimwade David , Ganser Arnold , Löwenberg Bob , Lo-Coco Francesco , Sanz Miguel A. , Berliner Nancy , Rego Eduardo M. 
Published: September 2017

Key Points
BAALC expression is significantly lower in APL compared with other subsets of AML and healthy volunteers. BAALC overexpression can independently predict shorter DFS in patients with high-risk disease.
Graft-Versus-Leukemia Effect of Allogeneic Stem-Cell Transplantation and Minimal Residual Disease in Patients With Acute Myeloid Leukemia in First Complete Remission
Authors: Versluis Jurjen , Kalin Burak , Zeijlemaker Wendelien , Passweg Jakob , Graux Carlos , Manz Markus G. , Vekemans Marie-Christiane , Biemond Bart J. , Legdeur Marie-Cecile J.C. , Kooy Marinus van Marwijk , de Weerdt Okke , Wijermans Pierre W. , Hoogendoorn Mels , Bargetzi Mario J. , Kuball Juergen , Schouten Harry C. , van der Velden Vincent H.J. , Janssen Jeroen J.W.M. , Pabst Thomas , Lowenberg Bob , Jongen-Lavrencic Mojca , Schuurhuis Gerrit Jan , Ossenkoppele Gert , Cornelissen Jan J. 
Published: September 2017

Purpose The detection of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) may improve future risk-adapted treatment strategies. We assessed whether MRD-positive and MRD-negative patients with AML benefit differently from the graft-versus-leukemia effect of allogeneic hematopoietic stem-cell transplantation (alloHSCT). Methods A total of 1,511 patients were treated in subsequent Dutch-Belgian Hemato-Oncology Cooperative Group and the Swiss Group for Clinical Cancer Research AML trials, of whom 547 obtained a first complete remission, received postremission treatment (PRT), and had available flow cytometric MRD before PRT. MRD positivity was defined as more than 0.1% cells with a leukemia-associated immunophenotype within the WBC compartment. PRT consisted of alloHSCT (n = 282), conventional PRT by a third cycle of chemotherapy (n = 160), or autologous hematopoietic stem-cell transplantation (n = 105). Results MRD was positive in 129 patients (24%) after induction chemotherapy before proceeding to PRT. Overall survival and relapse-free survival were significantly better in patients without MRD before PRT compared with MRD-positive patients (65% ± 2% v 50% ± 5% at 4 years; P = .002; and 58% ± 3% v 38% ± 4%; P < .001, respectively), which was mainly because of a lower cumulative incidence of relapse (32% ± 2% compared with 54% ± 4%; P < .001, respectively). Multivariable analysis with adjustment for covariables showed that the incidence of relapse was significantly reduced after alloHSCT compared with chemotherapy or autologous hematopoietic stem cell transplantation (hazard ratio [HR], 0.36; P < .001), which was similarly exerted in both MRD-negative and MRD-positive patients (HR, 0.38; P < .001; and HR, 0.35; P < .001, respectively). Conclusion The graft-versus-leukemia effect of alloHSCT is equally present in MRD-positive and MRD-negative patients, which advocates a personalized application of alloHSCT, taking into account the risk of relapse determined by AML risk group and MRD status, as well as the counterbalancing risk of nonrelapse mortality.
Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae
Authors: Wei Jiankai , Wang Guilin , Li Xiang , Ren Ping , Yu Haiyan , Dong Bo 
Published: September 2017

ABSTRACT
The extracellular matrix (ECM) not only provides essential physical scaffolding for cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis. In this study, we utilized wheat germ agglutinin (WGA) staining to characterize the ECM architecture in ascidian embryos and larvae. The results showed three distinct populations of ECM presenting in Ciona embryogenesis: the outer layer localized at the surface of embryo, an inner layer of notochord sheath and the apical ECM secreted by the notochord. To further elucidate the precise structure of Ciona embryonic ECM, we employed scanning and transmission electron microscopy, and found that the outer membrane was relatively thick with short fibres, whereas the ECM layer in notochord sheath was not as thick as the outer membrane but more regular arranged; the lumen between notochord cells was hydrostatic and sticky. Then, we used the RNA sequencing data from the embryos and larvae of Ciona savignyi to identify ECM genes and acquire their expression patterns. We identified 115 unigenes as 67 ECM genes, and 77 unigenes showed dynamic expression changes between different stages. Our results reveal the architecture, molecular composition and dynamic expression profile of ECM in ascidian embryogenesis, and may increase understanding of the function of the ECM in chordate development.
The effects of the exopolysaccharide and growth rate on the morphogenesis of the terrestrial filamentous cyanobacterium Nostoc flagelliforme
Authors: Cui Lijuan , Xu Haiyan , Zhu Zhaoxia , Gao Xiang 
Published: September 2017

ABSTRACT
The terrestrial cyanobacterium Nostoc flagelliforme, which contributes to carbon and nitrogen supplies in arid and semi-arid regions, adopts a filamentous colony form. Owing to its herbal and dietary values, this species has been overexploited. Largely due to the lack of understanding on its morphogenesis, artificial cultivation has not been achieved. Additionally, it may serve as a useful model for recognizing the morphological adaptation of colonial cyanobacteria in terrestrial niches. However, it shows very slow growth in native habitats and is easily disintegrated under laboratory conditions. Thus, a novel experimental system is necessary to explore its morphogenetic mechanism. Liquid-cultured N. flagelliforme has been well developed for exopolysaccharide (EPS) production, in which microscopic colonies (micro-colonies) are generally formed. In this study, we sought to gain some insight into the morphogenesis of N. flagelliforme by examining the effects of two external factors, the EPS and environmental stress-related growth rate, on the morphological shaping of micro-colonies. Our findings indicate that the EPS matrix could act as a basal barrier, leading to the bending of trichomes during their elongation, while very slow growth is conducive to their straight elongation. These findings will guide future cultivation and application of this cyanobacterium for ecological improvement.
PQN-75 is expressed in the pharyngeal gland cells of C
aenorhabditis
elegans and is dispensable for germline development
Authors: Rochester Jesse D. , Tanner Paige C. , Sharp Catherine S. , Andralojc Karolina M. , Updike Dustin L. 
Published: September 2017

ABSTRACT
In Caenorhabditis elegans, five pharyngeal gland cells reside in the terminal bulb of the pharynx and extend anterior processes to five contact points in the pharyngeal lumen. Pharyngeal gland cells secrete mucin-like proteins thought to facilitate digestion, hatching, molting and assembly of the surface coat of the cuticle, but supporting evidence has been sparse. Here we show pharyngeal gland cell expression of PQN-75, a unique protein containing an N-terminal signal peptide, nucleoporin (Nup)-like phenylalanine/glycine (FG) repeats, and an extensive polyproline repeat domain with similarities to human basic salivary proline-rich pre-protein PRB2. Imaging of C-terminal tagged PQN-75 shows localization throughout pharyngeal gland cell processes but not the pharyngeal lumen; instead, aggregates of PQN-75 are occasionally found throughout the pharynx, suggesting secretion from pharyngeal gland cells into the surrounding pharyngeal muscle. PQN-75 does not affect fertility and brood size in C. elegans but confers some degree of stress resistance and thermotolerance through unknown mechanisms.
A survey of quality of life indicators in the Romanian Roma population following the ‘Decade of Roma Inclusion’
Authors: Powell Doherty Rebecca , Müller-Demary Daniel , Hosszu Alexandra , Duminica Ana , Bertke Andrea , Lewis Bryan , Eubank Stephen 
Published: September 2017

Background: This study explores how the Roma in Romania, the EU’s most concentrated population, are faring in terms of a number of quality of life indicators, including poverty levels, healthcare, education, water, sanitation, and hygiene.Methods: 135 surveys were conducted across five geographically diverse Romanian communities. Household participants were selected through a comprehensive random walk method. Analyses were conducted on all data using Pandas for Python.Results: These data indicate that the Roma in Romania face significant disparities in education, with Roma students less likely to progress beyond 8thgrade. In addition, the Roma population remains significantly disadvantaged with regard to safe and secure housing, poverty, and healthcare status, particularly in connection to diarrheal disease. In contrast, however, both Roma and non-Roma in rural areas face difficulties regarding full-time employment, sanitation, and water, sanitation, and hygiene infrastructure.Conclusions: These data demonstrate the challenges that remain to the Roma population in Romania, and also point to the myriad of ways in which all rural Romanians, regardless of ethnicity, are encountering hardship. This study highlights the areas in which improvements can be made to ensure the Roma, and indeed all Romanian citizens, have access to and confidence in sanitation services, clean water, and adequate healthcare treatment.
Draft genome of tule elk Cervus elaphus nannodes
Authors: Mizzi Jessica E. , Lounsberry Zachary T. , Brown C. Titus , Sacks Benjamin N. 
Published: September 2017

This paper presents the first draft genome of the tule elk (Cervus elaphus nannodes), a subspecies native to California that underwent an extreme genetic bottleneck in the late 1800s. The genome was generated from Illumina HiSeq 3000 whole genome sequencing of four individuals, resulting in the assembly of 2.395 billion base pairs (Gbp) over 602,862 contigs over 500 bp and N50 = 6,885 bp. This genome provides a resource to facilitate future genomic research on elk and other cervids.
The Hot-Hand Fallacy: Cognitive Mistakes or Equilibrium Adjustments? Evidence from Major League Baseball
Authors: Green Brett , Zwiebel Jeffrey 
Published: September 2017

We test for a “hot hand” (i.e., short-term predictability in performance) in Major League Baseball using panel data. We find strong evidence for its existence in all 10 statistical categories we consider. The magnitudes are significant; being “hot” corresponds to between one-half and one standard deviation in the distribution of player abilities. Our results are in notable contrast to the majority of the hot-hand literature, which has generally found either no hot hand or a very weak hot hand in sports, often employing basketball shooting data. We argue that this difference is attributable to endogenous defensive responses: basketball presents sufficient opportunity for transferring defensive resources to equate shooting probabilities across players, whereas baseball does not. We then develop a method to test whether baseball teams do respond appropriately to hot opponents. Our results suggest teams respond in a manner consistent with drawing correct inference about the magnitude of the hot hand except for a tendency to overreact to very recent performance (i.e., the last five attempts).The online appendix is available at https://doi.org/10.1287/mnsc.2017.2804 .This paper was accepted by Amit Seru, finance.
EMERGING AREAS OF SHIELDING RESEARCH—A BIRD’S EYE VIEW
Authors: Dranga Ruxandra , Adams Frederick Powell 
Published: September 2017

Shielding analysis and design are important tools for ensuring that humans and the environment are protected from the detrimental effects of high levels of radiation. The fundamental principles and methodologies for shielding analysis and design, especially for reactor applications, have been developed and refined since the 1940s and the beginning of nuclear power research programs in Canada and internationally. Other applications are gaining importance due to both increased need and technological advances. In this work, a high-level survey of emerging areas in shielding research and development is provided. Areas of topical interest include remote reactor monitoring, source reconstruction and inverse shielding methods, waste management and decommissioning applications, accelerator, cyclotron, and other advanced medical shielding applications, space exploration, and new materials development. Each of these areas of interest is evaluated based on current capacity of the research community. They are also evaluated in terms of the benefits for the scientific community and industry arising from performing research including development of new technologies and techniques.