bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive Aspects of Caregiving and Caregiver Burden: A Study of Caregivers of Patients With Dementia
Authors: Abdollahpour Ibrahim , Nedjat Saharnaz , Salimi Yahya 
Published: November 2017

Background: Now positive aspect of caregiving (PAC) is well-defined as caregiver gains, satisfaction, meaningful life, and enhanced family relationship. The adjusted association of PAC and caregiver burden is not well acknowledged. This study investigated the association of caregiver burden and PAC adjusting for potential confounders. Methods: This was a cross-sectional study that recruited 132 caregivers. A linear regression model with PAC was used to estimate the adjusted associations. Results: The caregiver burden was negatively associated with PAC (mean difference in PAC per a 1-unit increase in caregiver burden = −0.12, 95% confidence interval: −0.18 to −0.056; P < .001). This association remained after adjustment for caregivers’ age and marital status as well as patients’ dependency level. Conclusion: The negative significant association of caregiver burden with PAC reinforces the need for interventional and/or educational programs aiming at decreasing the overall imposed burden. This can play an important role in improving caregivers’ general health and quality of life.
Actual versus recommended storage temperatures of oral anticancer medicines at patients’ homes
Authors: Vlieland ND , van den Bemt BJF , van Riet-Nales DA , Bouvy ML , Egberts ACG , Gardarsdottir H 
Published: November 2017

Background Substantial quantities of unused medicines are returned by patients to the pharmacy each year. Redispensing these medicines would reduce medicinal waste and health care costs. However, it is not known if medicines are stored by patients as recommended in the product label. Inadequate storage may negatively affect the medicine and reduce clinical efficacy whilst increasing the risk for side effects. Objective To investigate the proportion of patients storing oral anticancer medicines according to the temperature instructions in the product label. Methods Consenting adult patients from six Dutch outpatient hospital pharmacies were included in this study if they used an oral anticancer medicine during February 2014 – January 2015. Home storage temperatures were assessed by inclusion of a temperature logger in the original cancer medicines packaging. The primary outcome was the proportion of patients storing oral anticancer medicines as specified in the Summary of Product Characteristics, either by recalculating the observed temperature fluctuations to a single mean kinetic temperature or by following the temperature instructions taking into account a consecutive 24-h tolerance period. Results Ninety (81.1%) of the 111 included patients (47.8% female, mean age 65.2 (SD: 11.1)) returned their temperature loggers to the pharmacy. None of the patients stored oral anticancer medicines at a mean kinetic temperature above 25℃, one patient stored a medicine requiring storage below 25℃ longer than 24 h above 25℃. None of the patients using medicines requiring storage below 30℃ kept their medicine above 30℃ for a consecutive period of 24 h or longer. Conclusion The majority of patients using oral anticancer medicines store their medicines according to the temperature requirements on the product label claim. Based on our results, most oral anticancer medicines will not be negatively affected by temperature conditions at patients’ homes for a maximum of three months and are likely to be suitable for redispensing.
The effects of Baduanjin exercise on fatigue and quality of life in patients with heart failure: A randomized controlled trial
Authors: Chen Dai-Mei , Yu Wen-Chung , Hung Huei-Fong , Tsai Jen-Chen , Wu Hsiao-Ying , Chiou Ai-Fu 
Published: November 2017

Aims: The purpose of this study was to examine the effects of Baduanjin exercise on fatigue and quality of life in patients with heart failure. Methods: The study was a randomized controlled trial. Participants diagnosed with heart failure were recruited from two large medical centers in northern Taiwan. Participants were randomly assigned to the intervention ( n=39) or control ( n=41) groups. Patients in the intervention group underwent a 12-week Baduanjin exercise program, which included Baduanjin exercise three times per week for 12 weeks at home, a 35-minute Baduanjin exercise demonstration video, a picture-based educational brochure, and a performance record form. The control group received usual care and received no intervention. Fatigue and quality of life were assessed using a structural questionnaire at baseline, four weeks, eight weeks, and 12 weeks after the intervention. Results: Participants in the Baduanjin exercise group showed significant improvement in fatigue ( F=5.08, p=0.009) and quality of life ( F=9.11, p=0.001) over time from baseline to week 12 after the intervention. Those in the control group showed significantly worse fatigue ( F=3.46, p=0.033) over time from baseline to week 12 and no significant changes in quality of life ( F=0.70, p=0.518). Compared to the control group, the exercise group demonstrated significantly greater improvement in fatigue and quality of life at four weeks, eight weeks, and 12 weeks. Conclusions: This simple traditional exercise is recommended for Taiwanese patients with heart failure in order to improve their fatigue and quality of life.
Immune Abnormalities in Patients With Single Ventricle Circulation Precede the Fontan Procedure
Authors: Kovacikova Lubica , Krasnanova Veronika , Skrak Peter , Zahorec Martin , Kantorova Andrea , Semberova Jana , Bacharova Ljuba 
Published: November 2017

Background: Immune abnormalities are common in Fontan patients with protein-losing enteropathy. Limited data exist on immune function of other patients with single ventricle circulation. Methods: This prospective cohort study evaluated immunologic characteristics of children with single ventricle circulation from neonatal age up to early post-Fontan period. Results: Low leukocyte counts were observed in half of the patients prior to bidirectional Glenn and Fontan surgery. Total lymphocyte counts were below normal range in 36% to 63% of patients across all groups except patients following Fontan procedure who had normal counts. Typical lymphocyte subpopulation patterns were (1) high counts of total and helper T lymphocytes (CD3+ and CD4+ cells), low B lymphocytes (CD19+ cells), and increased CD4/CD8 ratio in neonates and (2) low T lymphocytes (CD3+, CD4+, CD8+ cells) with high natural killer cells (CD16+) and B lymphocytes (CD19+ cells) in other groups. Low preoperative total lymphocyte counts were associated with longer intensive care unit stay in patients after bidirectional Glenn and Fontan procedure ( P = .03 and P = .01, respectively) and low leukocyte counts with higher incidence of pleural effusions and chylothorax after Fontan procedure ( P = .005 and P = .002, respectively). Conclusions: Single ventricle patients display several immunological abnormalities. Beyond the neonatal age, an immune pattern includes CD3+, CD4+, CD8+ lymphopenia, and CD16+ and CD19+ lymphocytosis. B-cell lymphocytosis compensates T-cell lymphopenia, producing normal total lymphocyte counts in patients early after Fontan surgery. Low preoperative total lymphocyte counts may be associated with longer postoperative intensive care unit stay in patients with bidirectional Glenn and Fontan procedure and leukopenia with pleural effusions in Fontan patients.
Experience with an Acuity Adaptable Care Model for Pediatric Cardiac Surgery
Authors: Costello John M. , Preze Elizabeth , Nguyen Nguyenvu , McBride Mary E. , Collins James W. , Eltayeb Osama M. , Mongé Michael C. , Deal Barbara J. , Stephenson Michelle M. , Backer Carl L. 
Published: November 2017

Background: We describe the implementation of and outcomes associated with an acuity adaptable care model for pediatric patients undergoing cardiac surgery. Methods: Consecutive patients undergoing an index cardiac operation between July 2007 and June 2015 were included. From July 2007 through June 2010, a conventional model existed in which patients moved among units and care teams based on age, severity of illness, and operative status (conventional group). A transitional period existed between July 2010 and June 8, 2012 (transitional group). From June 9, 2012, through June 2015, an acuity adaptable model was used in which patients remained in the cardiac care unit and received care from the same clinical team throughout their hospitalization (acuity adaptable group). Results: Included were 2,363 patients: 925 in the conventional group, 520 in the transitional group, and 918 in the acuity adaptable group. In relation to the conventional group, the adjusted odds of operative mortality in the acuity adaptable group was 0.55 (95% confidence interval: 0.26-1.18; P = .12). The failure to rescue rate (ie, number of deaths in patients with any complication divided by the number of total patients with any complication) decreased (conventional group, 8.7%; acuity adaptable group, 4.2%; P = .04). In relation to the conventional group, postoperative hospital length of stay tended to be shorter in the acuity adaptable group ( P = .07). Conclusions: The implementation of an acuity adaptable care model was feasible in our pediatric cardiac program. The favorable associations identified between the new model and outcomes are promising but warrant confirmation in a larger, multicenter study.
Structure Follows Strategy at Bharat Petroleum
Authors: Machado Noel G. , Parambi Kurian , Venkatesan Pallavi 
Published: November 2017

This case reveals the story of organizational restructuring at Bharat Petroleum Corporation Limited (BPCL). The story begins in the 1990s when India’s petroleum industry was closed to private enterprise. BPCL’s chairman at that time (Sundararajan) anticipates that India’s government would deregulate the industry. He is concerned that without fundamental changes, BPCL might not survive private competition—and so, he initiates a transformation of the organization’s strategy and structure. The restructuring attempts to dismantle a command-and-control culture, and replace it by one of empowered teams. The change process is undertaken in the spirit of co-creation. The definition of ‘customer’ is altered, causing organizational boundaries to be redrawn. Such an exercise is extraordinary for its time. The case then presents a picture of BPCL and its challenges in 2015. History seems to repeat itself, as market conditions are nearly identical to those that existed 17 years ago. What should the company do in 2015? This case has a three-fold purpose; viz. (i) to show how the structure of an organization can be aligned with its business strategy; (ii) to illustrate how organizations with a functional structure can reorganize to an ‘M-form’ or SBU structure; and (iii) to help readers consider the latent, long-term effects of restructuring.
Characterizing indeterminate (Likert-score 3/5) peripheral zone prostate lesions with PSA density, PI-RADS scoring and qualitative descriptors on multiparametric MRI
Authors: Brizmohun Appayya Mrishta , Sidhu Harbir S , Dikaios Nikolaos , Johnston Edward W , Simmons Lucy AM , Freeman Alex , Kirkham Alexander PS , Ahmed Hashim U , Punwani Shonit 
Published: November 2017

Objective:
To determine whether indeterminate (Likert-score 3/5) peripheral zone (PZ) multiparametric MRI (mpMRI) studies are classifiable by prostate-specific antigen (PSA), PSA density (PSAD), Prostate Imaging Reporting And Data System version 2 (PI-RADS_v2) rescoring and morphological MRI features.

Methods:
Men with maximum Likert-score 3/5 within their PZ were retrospectively selected from 330 patients who prospectively underwent prostate mpMRI (3 T) without an endorectal coil, followed by 20-zone transperineal template prostate mapping biopsies ＋/- focal lesion-targeted biopsy. PSAD was calculated using pre-biopsy PSA and MRI-derived volume. Two readers A and B independently assessed included men with both Likert-assessment and PI-RADS_v2. Both readers then classified mpMRI morphological features in consensus. Men were divided into two groups: significant cancer (≥ Gleason 3 ＋ 4) or insignificant cancer (≤ Gleason 3 ＋ 3)/no cancer. Comparisons between groups were made separately for PSA & PSAD using Mann–Whitney test and morphological descriptors with Fisher’s exact test. PI-RADS_v2 and Likert-assessment were descriptively compared and percentage inter-reader agreement calculated.

Results:
76 males were eligible for PSA & PSAD analyses, 71 for PI-RADS scoring, and 67 for morphological assessment (excluding significant image artefacts). Unlike PSA (p = 0.915), PSAD was statistically different (p = 0.004) between the significant [median: 0.19 ng ml– 2 (interquartile range: 0.13–0.29)] and non-significant/no cancer [median: 0.13 ng ml– 2 (interquartile range: 0.10–0.17)] groups. Presence of mpMRI morphological features was not significantly different between groups. Subjective Likert-assessment discriminated patients with significant cancer better than PI-RADS_v2. Inter-reader percentage agreement was 83% for subjective Likert-assessment and 56% for PI-RADS_v2.

Conclusion:
PSAD may categorize presence of significant cancer in patients with Likert-scored 3/5 PZ mpMRI findings.

Advances in knowledge:
PSAD may be used in indeterminate PZ mpMRI to guide decisions between biopsy vs monitoring.
Impact of detecting potentially serious incidental findings during multi-modal imaging
Authors: Gibson Lorna M , Littlejohns Thomas J , Adamska Ligia , Garratt Steve , Doherty Nicola ,   UK Biobank Imaging Working Group, Wardlaw Joanna M , Maskell Giles , Parker Michael , Brownsword Roger , Matthews Paul M , Collins Rory , Allen Naomi E , Sellors Jonathan , Sudlow Cathie LM 
Published: November 2017

Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging. We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants (radiographer ‘flagging’ with radiologist confirmation of potentially serious IFs) compared with systematic radiologist review of all images. Methods: Brain, cardiac and body magnetic resonance, and dual-energy x-ray absorptiometry scans from the first 1000 imaged UK Biobank participants were independently assessed for potentially serious IFs using both protocols. We surveyed participants with potentially serious IFs and their GPs up to six months after imaging to determine subsequent clinical assessments, final diagnoses, emotional, financial and work or activity impacts. Results: Compared to systematic radiologist review, radiographer flagging resulted in substantially fewer participants with potentially serious IFs (179/1000 [17.9%] versus 18/1000 [1.8%]) and a higher proportion with serious final diagnoses (21/179 [11.7%] versus 5/18 [27.8%]). Radiographer flagging missed 16/21 serious final diagnoses (i.e., false negatives), while systematic radiologist review generated large numbers of non-serious final diagnoses (158/179) (i.e., false positives). Almost all (90%) participants had further clinical assessment (including invasive procedures in similar numbers with serious and non-serious final diagnoses [11 and 12 respectively]), with additional impact on emotional wellbeing (16.9%), finances (8.9%), and work or activities (5.6%). Conclusions: Compared with systematic radiologist review, radiographer flagging missed some serious diagnoses, but avoided adverse impacts for many participants with non-serious diagnoses. While systematic radiologist review may benefit some participants, UK Biobank’s responsibility to avoid both unnecessary harm to larger numbers of participants and burdening of publicly-funded health services suggests that radiographer flagging is a justifiable approach in the UK Biobank imaging study. The potential scale of non-serious final diagnoses raises questions relating to handling IFs in other settings, such as commercial and public health screening.
Structural Role Complementarity in Entrepreneurial Teams
Authors: Aven Brandy , Hillmann Henning 
Published: November 2017

To refine the understanding of the social network characteristics of entrepreneurial teams, we present a new construct: structural role complementarity. In particular, we examine the variation between team members’ respective abilities to act as network brokers. Based on the cofounding networks of 9,461 entrepreneurs and 2,446 large-scale industrial enterprises over 45 years in Russia’s emerging economy (1869–1913), our findings show that variation among team members’ brokering ability significantly predicts the starting capital raised by their firm. The effect is moderated by the team’s average brokering potential. When both the team’s average and variation in brokering potential is high, firms raise greater starting capital. By using multiple membership models, we demonstrate that greater starting capital is largely attributable to team factors rather than the attributes of the individual team members. We also take advantage of discriminatory laws that were passed in 1887 in an instrumental variable analysis to address potential endogeneity issues.The online appendix is available at https://doi.org/10.1287/mnsc.2017.2874 .This paper was accepted by Olav Sorenson, organizations.
Script development and academic research
Authors: Price Steven 
Published: November 2017

Abstract
This article seeks to bring screenwriting research and screenwriting practice studies into closer proximity. It outlines arguments for seeing them as distinct fields, but suggests that doing so has contributed towards significant misunderstandings between practitioners and researchers. They are united in relying on both textual and non-textual materials, including anecdotal and first-person testimony; they face common problems in aligning these materials with traditional scholarly standards and overcoming the fragmentation of a field that is currently dominated by individual case studies; and they share some of the methodological and theoretical concerns of adaptation studies, with the term ‘script development’ itself risking the marginalization of intermedial and non-linear iterations. It concludes that collaboration between practitioners and researchers is essential if the study of script development is to flourish.
Percepção de mães de recém-nascidos prematuros sobre o cuidado intensivo neonatal
Authors: Palmarella Neto Mauro , Gomes da Silva Valéria , Pires Dutra Laisla 
Published: November 2017

O objetivo do estudo foi conhecer a percepção de mães de recém-nascidos prematuros sobre o cuidado intensivo neonatal. Trata-se de um estudo qualitativo, descritivo e exploratório, realizado com 9 mães de filhos internados em unidades de cuidado intensivo neonatal. As participantes responderam um questionário biosociodemográfico e posteriormente foi solicitado que realizassem um desenho representando seus sentimentos durante o período de internação. Para análise dos dados foi realizado a técnica de análise de conteúdo das histórias temáticas e análise do grafismo. Os resultados foram descritos através da caracterização das mães e a percepção das mesmas sobre o processo de internamento no cuidado intensivo neonatal apresentado em 2 categorias, a primeira: os sentimentos maternos vivenciados durante a hospitalização do filho na unidade de terapia intensiva neonatal, e a segunda: espiritualidade e crenças religiosas. Conclui-se que essa fase do internamento submete as mães a vários sentimentos, seja eles bons e ruins.
Prevalensi dan jenis masalah emosional dan perilaku pada anak usia 9-11 tahun dengan perawakan pendek di Kabupaten Brebes
Authors: Rahmadi Farid Agung , Hardaningsih Galuh , Pratiwi Rina 
Published: November 2017

Latar belakang. Diperkirakan prevalensi masalah emosional dan perilaku pada anak adalah sebesar 20%. Terdapat berbagai macam jenis masalah emosional dan perilaku seperti gangguan emosi, gangguan perilaku, hiperaktif, dan masalah dengan teman sebaya. Masalah emosional dan perilaku dipengaruhi oleh multifaktor yang masing-masing dapat berdiri sendiri atau saling mempengaruhi. Nutrisi dan stimulasi yang adekuat sebagai dasar perkembangan anak wajib diberikan secara optimal. Perawakan pendek merupakan salah satu bentuk dari gangguan nutrisi kronik yang dapat menimbulkan berbagai macam masalah emosional dan perilaku pada anak. Mengingat penatalaksanaan masalah emosional dan perilaku tidak dapat dilaksanakan sebelum dilakukannya identifikasi jenis masalah emosional dan perilaku, maka identifkasi jenis masalah emosional dan perilaku penting untuk dilakukan.Tujuan penelitian. Mengetahui prevalensi dan jenis masalah emosional dan perilaku yang terjadi pada anak dengan perawakan pendek.Metode penelitian. Merupakan penelitian observasional deskriptif. Penelitian dilakukan di beberapa sekolah dasar di Kabupaten Brebes. Subyek penelitian adalah anak berperawakan pendek umur 9-11 tahun. Variabel yang diteliti adalah masalah emosional dan perilaku pada anak perwakan pendek menggunakan kuesioner SDQ. Hasil Penelitian. Sebanyak 70 anak perawakan pendek terdiri dari 30(42.85%) anak perempuan, dengan rerata umur subyek 121.14±6.62 bulan. Subyek dengan nilai total kesulitan abnormal sebanyak 6(8%) dan borderline 28(40%). Skala gangguan emosi abnormal sebanyak 17(24.2%) dan borderline 12(17.1%). Subyek dengan skala masalah perilaku abnormal sebanyak 19(27.1%) dan borderline sebanyak 21(30%). Subyek dengan skor masalah dengan teman sebaya dalam klasifikasi abnormal sebanyak 23(32.8%) dan borderline 18(25.7%).Simpulan. Prevalensi masalah emosional dan perilaku yang terjadi pada anak dengan perawakan pendek lebih tinggi daripada prevalensi masalah emosional dan perilaku pada populasi anak normal. Urutan jenis masalah yang paling tinggi adalah masalah dengan teman sebaya, kemampuan prososial yang kurang, masalah perilaku dan emosi.
The Case for the Stateless Society: Law
Authors: Chamberlin Antón , Block Walter E. 
Published: November 2017

Abstract
What is the argument against government? There are several. For one thing, there is automatic exit for failure: businesses that do not earn a profit go bankrupt, and their resources tend to migrate to other, more effective, managers. For another, entrepreneurs operate with their own funds, or those voluntarily entrusted to them. This does not apply to bureaucrats and politicians, in sharp contrast. Perhaps most important, in the case of each and every commercial interaction in the market, buying, selling, renting, lending, borrowing, there is mutual gain at least in the ex ante sense of anticipations, and usually ex post, after the trade, as well. This rarely occurs under statism, at least not with regard to its source of funds, taxation, since it is not voluntary. An exception would be the relatively unimportant cases in which a consumer purchases something from the government, such as a ticket to cross a bridge, or a producer sells something to this organization, such as an airplane. The present paper is an attempt to elaborate upon this considerations.
Land Register Entry as the Condition for Real Estate Transactions and Investments
Authors: Babić Marko 
Published: November 2017

Abstract
This article deals mostly with land registers. It demonstrates clearly what is the significance of this legal element in continental European legal systems especially those who follow Germanic legal tradition (like Croatia). As such, land registers provide legal certainty and transparency which are highly desired and valued among potential business investors. Therefore, we may rightly award it with cornerstone status within the law of real property.