bluuebunny/crossref_metadata_2025_split huggingface dataset:
A short guideline on chronic kidney disease for medical laboratory practice / Kronik böbrek hastalığında tıbbi laboratuvar uygulamaları için kısa kılavuz
Authors: Abuşoğlu Sedat , Aydın İlknur , Bakar Funda , Bekdemir Tan , Gülbahar Özlem , İşlekel Hüray , Özarda Yeşim , Pektaş Macit , Pir Kamil , Portakal Oytun , Serdar Muhittin , Turhan Turan , Yüce Doğan , Zengi Oğuzhan 
Published: August 2016

Abstract
Chronic kidney disease (CKD) is asymptomatic in the early stage. Kidney function might be lost 90% when the symptoms are overt. However, in case of early detection, progression of the disease can be prevented or delayed. If not detected it results in end stage renal disease. Therefore, the level of awareness about CKD should be increased. The role of medical laboratory is utmost important for the diagnosis and staging of CKD. In this paper, the main tasks of the laboratory specialists are described and the outlines are as follows.
• Creatinine assays should be traceable to internationally recognised reference materials and methods, specifically isotope dilution mass spectrometry.
• When reporting the creatinine result, eGFR should also be reported in adult (>18 years) population. A warning expression should be included in the report form if eGFR result is <60 mL/min/1.73 m2.
• eGFR values should be expressed quantitatively up to 90 mL/min/1.73 m2 by CKD-EPI equation. Above 90 mL/ min/1.73 m2, eGFR values can be expressed quantitatively or >90 mL/min/1.73 m2.
• eGFR equations of the adult population should not be used for pediatric population. Different equations utilizing also patient height should be used. The enzymatic creatinine assay should be preferred. eGFR based on cystatin C can be used for confirmation in the pediatric population.
• Cystatin C measurements, at least when eGFR based on creatinine is not reliable and for confirmation should be encouraged.
• Proteinuria or albuminuria values should be measured in spot samples and reported in proportion to creatinine.
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer
Authors: Sas‐Chen Aldema , Aure Miriam R , Leibovich Limor , Carvalho Silvia , Enuka Yehoshua , Körner Cindy , Polycarpou‐Schwarz Maria , Lavi Sara , Nevo Nava , Kuznetsov Yuri , Yuan Justin , Azuaje Francisco ,   Oslo Breast Cancer Research Consortium (OSBREAC), Ulitsky Igor , Diederichs Sven , Wiemann Stefan , Yakhini Zohar , Kristensen Vessela N , Børresen‐Dale Anne‐Lise , Yarden Yosef 
Published: August 2016

AbstractLong noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal‐like subtype associates with increased EGFR signaling, while another, the HER2‐enriched subtype, engages a kin of EGFR. Based on the premise that EGFR‐regulated lncRNAs might control the aggressiveness of basal‐like tumors, we identified multiple EGFR‐inducible lncRNAs in basal‐like normal cells and overlaid them with the transcriptomes of over 3,000 breast cancer patients. This led to the identification of 11 prognostic lncRNAs. Functional analyses of this group uncovered LINC01089 (here renamed LncRNA Inhibiting Metastasis; LIMT), a highly conserved lncRNA, which is depleted in basal‐like and in HER2‐positive tumors, and the low expression of which predicts poor patient prognosis. Interestingly, EGF rapidly downregulates LIMT expression by enhancing histone deacetylation at the respective promoter. We also find that LIMT inhibits extracellular matrix invasion of mammary cells in vitro and tumor metastasis in vivo. In conclusion, lncRNAs dynamically regulated by growth factors might act as novel drivers of cancer progression and serve as prognostic biomarkers.
MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Krul-Poel Yvonne H M , ter Wee Marieke M , Lips Paul , Simsek Suat 
Published: August 2016

Objective
Epidemiologic studies suggest that vitamin D status plays a role in glycaemic control in patients with type 2 diabetes. However, intervention studies yielded inconsistent results. The aim of this study is to systematically review the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes.

Methods
Systematic review and meta-analysis. We searched Medline, Embase and the Cochrane Library for RCTs examining the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. A random-effects model meta-analysis was performed to obtain a summarized outcome of vitamin D supplementation on HbA1c, fasting glucose and homeostasis model assessment – insulin resistance (HOMA-IR).

Results
Twenty-three RCTs were included in this systematic review representing a total of 1797 patients with type 2 diabetes. Mean (± s.d.) change in serum 25-hydroxyvitamin D varied from 1.8 ± 10.2 nmol/L to 80.1 ± 54.0 nmol/L. Nineteen studies included HbA1c as outcome variable. Combining these studies no significant effect in change of HbA1c was seen after vitamin D intervention compared with placebo. A significant effect of vitamin D supplementation was seen on fasting glucose in a subgroup of studies (n = 4) with a mean baseline HbA1c ≥ 8% (64 mmol/mol) (standardized difference in means: 0.36; 95% CI: 0.12–0.61, P = 0.003).

Conclusions
Current evidence of RCTs does not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. However, in patients with poorly controlled diabetes, a favourable effect of vitamin D is seen on fasting glucose.
Hearing impairment and contributing factors among fertilizer factory workers
Authors: Jeffree Mohammad Saffree , Ismail Noorhassim , Lukman Khamisah Awang 
Published: August 2016

IntroductionHearing impairment remains the main occupational health problem in the manufacturing industry, and its contributing factors have not been well controlled.MethodsUnmatched case control and comparative studies were carried out among fertilizer factory workers in Sarawak with the aim of determining contributing factors for hearing impairment. Respondents consisted of 49 cases that were diagnosed from 2005 to 2008 with 98 controls from the same work places. Chisquare test and Mann‐Whitney test were used in a univariate analysis to determine the association between hearing impairment and the contributing risks being studied.ResultsThe results of the univariate analysis showed that hearing impairment was significantly (p < 0.05) associated with older age, lower education level, high smoking dose, high occupational daily noise dose, longer duration of service, infrequent used of hearing protection device (HPD), and low perception of sound on HPD usage. Multivariate logistic regression of hearing impairment after controlling for age found the following five variables: occupational daily noise dose �50% (OR 3.48, 95% CI 1.36‐8.89), �15 years of services (OR 2.92, 95% CI 1.16‐7.33), infrequent use of HPD (OR 2.79, 95% CI 1.15‐6.77), low perception of sound on HPD (POR 2.77, 95% CI 1.09‐6.97), and smoking more than 20 packs per year (OR 4.71, 95% CI 1.13‐19.68).DiscussionIn conclusion, high occupational noise exposure level, longer duration of service, low perception of sound on HPD, infrequent used of HPD, and smoking more than 20 packs per year were the contributing factors to hearing impairment, and appropriate intervention measures should be proposed and taken into considerations.
An advanced case of indium lung disease with progressive emphysema
Authors: Nakano Makiko , Tanaka Akiyo , Hirata Miyuki , Kumazoe Hiroyuki , Wakamatsu Kentaro , Kamada Dan , Omae Kazuyuki 
Published: August 2016

ObjectivesTo report the occurrence of an advanced case of indium lung disease with severely progressive emphysema in an indium‐exposed worker.Case reportA healthy 42‐year‐old male smoker was employed to primarily grind indium‐tin oxide (ITO) target plates, exposing him to indium for9 years (1998‐2008). In 2004, an epidemiological study was conducted on indium‐exposed workers at the factory in which he worked. The subject'sserum indium concentration (In‐S) was 99.7 μg/l, while his serum Krebs von den Lungen‐6 level was 2,350 U/ml. Pulmonary function tests showed forced vital capacity (FVC) of 4.17 l (91.5% of the JRS predicted value), forced expiratory volumein 1 s (FEV1) of 3.19 l (80.8% of predicted), and an FEV1‐to‐FVC ratio of 76.5%. A high‐resolution chest computed tomography (HRCT) scan showed mild interlobular septal thickening and mild emphysematous changes. In 2008, he was transferred from the ITO grinding workplace to an inspection work section, where indium concentrations in total dusts had a range of 0.001‐0.002 mg/m3. In 2009, the subject's In‐S had increased to 132.1 μg/l, and pulmonary function tests revealed obstructive changes. In addition, HRCT scan showed clear evidence of progressive lung destruction with accompanying severe centrilobular emphysema and interlobular septal thickening in both lung fields. The subject's condition gradually worsened, and in 2015, he was registered with the Japan Organ Transplant Network for lung transplantation (LTx).ConclusionsHeavy indium exposure is a risk factor for emphysema, which can lead to a severity level that requires LTx as the final therapeutic option.
Buffering effect of workplace social capital on the association of job insecurity with psychological distress in Japanese employees: a cross‐sectional study
Authors: Inoue Akiomi , Kawakami Norito , Eguchi Hisashi , Tsutsumi Akizumi 
Published: August 2016

ObjectivesThe present study aimed to examine the buffering effect of workplace social capital (WSC) on the association of job insecurity with psychological distress in Japanese employees.Methods2,971 employees from two factories of a manufacturing company in Japan completed a self‐administered questionnaire including the scales on job insecurity, WSC, psychological distress, demographic and occupational characteristics, and quantitative workload. Using psychological distress (defined as a total score of the K6 scale �5) as a dependent variable, multiple logistic regression analyses were conducted. In a series of analyses, interaction term of job insecurity×WSC was included in the model.ResultsAfter adjusting for demographic and occupational characteristics as well as for quantitative workload and interaction effect of quantitative workload× WSC, high job insecurity and low WSC were significantly associated with psychological distress. Furthermore, a significant interaction effect of job insecurity×WSC was observed. Specifically, the association of job insecurity with psychological distress was greater among those who perceived lower levels of WSC (prevalence odds ratio=3.79 [95% confidence interval=2.70‐5.32] for high vs. low job insecurity subgroup) than among those who perceived higher levels of WSC (prevalence odds ratio=2.96 [95% confidence interval=2.19‐4.01] for high vs. low job insecurity subgroup) . These findings were replicated among permanent male employees in the gender‐stratified analyses.ConclusionsThe present study suggests that WSC has a buffering effect on the association of job insecurity with psychological distress at least among Japanese permanent male employees.
Analysis of Real-World Data on Overall Survival in Multiple Myeloma Patients With ≥3 Prior Lines of Therapy Including a Proteasome Inhibitor (PI) and an Immunomodulatory Drug (IMiD), or Double Refractory to a PI and an IMiD
Authors: Usmani Saad , Ahmadi Tahamtan , Ng Yvette , Lam Annette , Desai Avinash , Potluri Ravi , Mehra Maneesha 
Published: August 2016

Abstract

Background.
This retrospective study evaluated the treatment patterns in and overall survival (OS) of multiple myeloma (MM) patients who were refractory to a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD) or who had received three or more prior lines of therapy (LOTs) including a PI and an IMiD.

Methods.
Electronic health records in the IMS LifeLink and OPTUM databases were screened for indexing periods of 2000–2014 and 2007–2014, respectively. Patients who were refractory to both a PI and an IMiD (criterion 1) or who received three or more prior LOTs (including a PI and an IMiD) and showed disease progression within 60 days of their most recent regimen (criterion 2) comprised the eligible population. Median OS from time of last LOT was assessed for the full cohort, cohorts meeting criteria 1 and 2, and clinically important subgroups.

Results.
Of 3,929 and 3,837 patients with MM diagnoses evaluated in the IMS LifeLink and OPTUM databases, 500 and 162 met the eligibility criteria, respectively. Similar median OS was observed for eligible patients in the IMS LifeLink and OPTUM databases (7.9 vs. 7.9 months; p = .5358). In subgroup analyses of the IMS LifeLink data set, median OS was longer in patients &lt;65 years of age than it was for those ≥65 years at eligibility (9.5 vs 6.7 months; p &lt; .01) and in patients with good or unreported versus poor performance status at last claim (7.8 or 8.8 vs. 2.9 months; p &lt; .0001).

Conclusion.
The findings of this survival analysis suggest that outcomes for these patients remain poor despite the availability of newer agents.
Briefing: Minimum effective kerb height for blind and partially sighted people
Authors: Thomas Carol 
Published: August 2016

This paper discusses the problems that blind and partially sighted people have in town centres where a ‘shared space’ design has been created using a shared surface for pedestrians and traffic. It reveals the results of a study which shows that a kerb height of 60 mm is required to ensure that the edge of a footway can be detected by blind and partially sighted pedestrians; and proposes that this should be used along with dropped kerb crossings and tactile paving, and other design features to influence user behaviour in a shared space development. The Guide Dogs for the Blind Association (Guide Dogs), supported by over 30 organisations across the disability sector, has called for a moratorium on new shared surface schemes until the Department for Transport has completed its review of how the shared space concept can be delivered to be accessible for all users. The concept of ‘shared space’ is based upon the observation that traffic and pedestrian behaviour is more affected by the built environment than it is by conventional traffic regulations. Introducing ambiguity and uncertainty for drivers may instil caution in the driver, but this ambiguity should not also extend to vulnerable pedestrians so as to undermine their confidence and safety.
Seismic performance of timber buildings: the Series project
Authors: Piazza Maurizio , Tomasi Roberto , Grossi Paolo , Costa Alfredo Campos , Candeias Paulo Xavier 
Published: August 2016

This paper describes a shaking-table experimental programme performed on four different multi-storey timber houses within the transnational Seismic Engineering Research Infrastructures for European Synergies (Series) project at the National Laboratory of Civil Engineering in Lisbon, Portugal. The aim of the Series project was to promote cooperation between main European research centres by giving access to their facilities. Under the timber buildings research programme within the Series framework, four real-scale three-storey buildings of plan dimension 7 × 5 m were assembled and tested: two timber-frame houses, one log house and one cross-glued laminated timber house. This paper describes the common parts of the various tests undertaken, such as the test set-up and the measurement layout. The tests themselves are described in a series of companion papers by the authors.
Menumbuhkan Rasa Percaya Diri Mahasiswa dalam Iklim Belajar Mengajar Melalui Kreativitas Seni
Authors: Sutini Ai 
Published: August 2016

<p>Penelitian ini didasari karena rasa percaya diri mahasiswa belum tumbuh. Kreativitas kurang, malu, takut dalam bersikap. Maka melalui perkuliahan seni, diharapkan mahasiswa mendapat rangsangan (stimulus) untuk mencipta, mencoba sehingga ada kebebasan untuk berkreativitas seni. </p><p>Penelitian ini dilakukan di program D 2 PGTK Universitas Pendidikan Indonesia Kampus Cibiru dengan subjek mahasiswa semester 4 tahun akademik 2006‐2007 sebanyak 26 orang. Metode yang digunakan kreatif, praktek dan latihan. Hasil penelitian menunjukan : (1) mahasiswa lebih aktif dan kreatif dalam berekspresi dan bereksplorasi melalui seni (2) mahasiswa lebih percaya diri.</p>
Mengembangkan Kemampuan Pemecahan Masalah Matematika Siswa Melalui Menyelesaikan Soal Cerita Menggunakan Tahapan POLYA
Authors: - Komariah 
Published: August 2016

<p>Abstrak </p><p>Salah satu tujuan dari pembelajaran matematika di tingkat SD menurut kurikulum 2004 dan KTSP adalah mengembangkan kemampuan memecahkan masalah.Berdasarkan orientasi lapangan pada salah satu SD di dari hasil tes kemampuan pemecahan masalah matematika siswa masih tergolong rendah Masalah pada penelitian ini (1) bagaimana kualitas kemampuan pemecahan masalah matematika siswa ditinjau dari setiap tahap pemecahan masalah dan secara keseluruhan selama proses pembelajaran berlangsung? (2) bagaimana aktivitas siswa pada kegiatan diskusi kelompok selama proses pembelajaran berlangsung? (3) bagaiman tanggapan siswa terhadap pembelajaran pemecahan masalah matematika melalui diskusi kelompok? Pembelajaran pemecahan masalah matematika pada penelitian ini ditinjau dari setiap tahap pemecahan masalah dan secara keseluruhan langkah selama proses pembelajaran berlangsung. Langkah pemecahan masalah menurut Polya meliputi (1) memahami masalah, (2) merencanakan penyelesaian, (3) melaksanakan penyelesaian, (4) memeriksa kembali hasil, serta secara keseluruhan. Metoda yang dipergunakan penelitian tindakan kelas terhadap siswa kelas VI SD CIbiru VII Bandung terdiri dari 38 orang siswa dengan setting kelas kegiatan diskusi kelompok. Instrumen dalam penelitian ini tes, observasi, angket. Hasil penelitian menunjukkan pada siklus I kualitas kemampuan pemecahan masalah matematika siswa masih rendah, sebagian kelompok salah mengartikan soal pada tahap memahami masalah, tahap merencanakan penyelesaian dan secara keseluruhan langkah. Pada siklus II ada kemajuan semua kelompok siswa dapat menyelesaikan soal namun ada kelompok siswa yang masih salah mengartikan soal pada tahap memahami masalah dan dan secara keseluruhan langkah masih salah menghitung. Pada siklus III semua kelompok dapat menyelesaikan soal namun pada tahap secara keseluruhan masih ada kelompok siswa yang salah dalam menghitung terutama dalam membagi dan membulatkan. Hasil tes akhir menunjukkan kemampuan pemecahan masalah matematika siswa secara keseluruhan tergolong baik dan relative homogen mendekati rata‐rata. Aktivitas siswa pada kegiatan diskusi kelompok pada siklus I siswa belum dapat menyesuaikan diri dengan situasi pembelajaran yang diciptakan pada akhir siklus I dan pada siklus II serta III kegiatan diskusi lebih hidup dan kondusif yang dapat mengembangkan kemampuan pemecahan masalah matematika siswa. Siswa memberikan respon positif terhadap pembelajaranpemecahan masalah matematika. Kesulitan yang dihadapi siswa pada tahap memahami masalah dan pada tahap merencanakan penyelesaian.</p><p>Kata Kunci: Kemampuan pemecahan masalah matematika, Soal Cerita, Langkah Polya</p>
Remediasi Kesulitan Mahasiswa PGSD Menyusun Alat Penilaian Hasil Belajar Menurut Kelas Melalui Kerja kelompok
Authors: Setiamihardja Realin 
Published: August 2016

<p>Abstrak </p><p>Penelitian Penelitian yang berjudul “Remediasi Kesulitan Mahasiswa PGSD Menyusun Alat Penilaian Hasil Belajar Berbasis Kelas Melalui Kerja Kelompok “ dilakukan di PGSD Kampus Cibiru. Tujuan yang ingin dicapai dalam penelitian ini adalah meningkatkan kemampuan mahasiswa dalam menyusun alat penilaian hasil belajar berbasis kelas. Kesimpulan hasil penelitian tindakan kelas ini adalah: 1) adanya peningkatan aktifitas belajar mahasiswa dalam menyusun alat penilaian bentuk pilihan ganda, isian singkat dan uraian; 2) mahasiswa memperoleh pengalaman belajar secara utuh yang saling terkait dalam kemampuan penyusunan alat penilaian hasil belajar; 3) adanya peningkatan motivasi belajar; 4) mahasiswa memperoleh pengalaman belajar yang bermakna serta menciptakan hubungan yang akrab antara mahasiswa dengan pengajar; dan 5) adanya peningkatan kemampuan mahasiswa dalam penyusunan alat penilaian hasil belajar, melalui tukar pendapat, berbagi pengalaman dan kegiatan diskusi bersama teman sekelompoknya.</p><p>Kata Kunci: Alat Penilaian, Kerja Kelompok</p>
Abscisic acid and blue light signaling pathways in chloroplast movements in Arabidopsis mesophyll
Authors: Eckstein Aleksandra , Krzeszowiec Weronika , Banaś Agnieszka Katarzyna , Janowiak Franciszek , Gabryś Halina 
Published: August 2016

Abscisic acid (ABA) and phototropins act antagonistically to control stomatal movements. Here, we investigated the role of ABA in phototropin-directed chloroplast movements in mesophyll cells of Arabidopsis thaliana. We analyzed the expression of phototropins at mRNA and protein level under the influence of ABA. PHOT1 mRNA level was decreased by ABA in the dark while it was insensitive to ABA in light. PHOT2 mRNA level was independent of the hormone treatment. The levels of phototropin proteins were down-regulated by ABA, both in darkness and light. No impact of exogenous ABA on amplitudes and kinetics of chloroplast movements was detected. Chloroplast responses in wild type Arabidopsis and three mutants, abi4, abi2 (abscisic acid insensitive4, 2) and aba1 (abscisic acid1), were measured to account for endogenous ABA signaling. The chloroplast responses were slightly reduced in abi2 and aba1 mutants in strong light. To further investigate the effect, abi2 and aba1 mutants were supplemented with exogenous ABA. In the aba1 mutant, the reaction was rescued but in abi2 it was unaffected. Our results show that ABA is not directly involved in phototropin-controlled chloroplast responses in mature leaves of Arabidopsis. However, the disturbance of ABA biosynthesis and signaling in mutants affects some elements of the chloroplast movement mechanism. In line with its role as a stress hormone, ABA appears to enhance plant sensitivity to light and promote the chloroplast avoidance response.
Study of Natural Radioactive Elements in The Environment of Bundelkhand Region
Authors: Garg H. K. , Agrawal Rajiv , Garg Udita 
Published: August 2016

<em>Natural radioactive elements have been studied in the environment of some remote areas of Bundelkhand region. The nuclear radiations emitted were found as human health hazards by the applications of solid state nuclear track detector. Natural radioactive elements were mainly investigated as uranium and its radioactive products like radium and radon using nuclear technique such as laser flourimetry and γ-rays spectrometry radiation induced effect in the material were studied using heavy ion and irradiation facilities. </em>