bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of a “green” loyalty program on service encounter satisfaction
Authors: Liu Stephanie Q. , Mattila Anna S. 
Published: October 2016

PurposePresently, loyalty programs often offer preferential treatment to the firm’s best customers, and recently, service firms started to incorporate corporate social responsibility (CSR) initiatives into the loyalty reward programs (e.g. Starwood’s “Make A Green Choice”). However, academic research advancing the understanding of the effectiveness of CSR-focused loyalty programs is lacking. To bridge that gap, this paper aims to examine the influence of a “green” loyalty program on members’ and bystanders’ service encounter satisfaction in light of preferential treatment. Furthermore, this paper investigates the psychological mechanisms (prosociality perceptions and status perceptions) that underlie these effects.Design/methodology/approachThis study used a 2 (loyalty program: green vs standard) × 2 (customer type: member vs bystander) × 2 (observability of preferential treatment: low vs high) between-subjects experimental design. Respondents were asked to read a hotel check-in scenario and then completed scales that measured their perceptions and evaluations of the service encounter.FindingsResults from this study suggest that a green loyalty program can buffer the negative effect of preferential treatment on bystanders’ service encounter satisfaction. An examination of the underlying mechanism reveals that prosociality perceptions of the firm mediate the impact of loyalty programs on bystanders’ satisfaction. As expected, the results show that a green loyalty program is as effective as a standard program in elevating members’ satisfaction. Furthermore, findings from a moderated mediation analysis indicate that status perceptions mediate the impact of customer type on satisfaction. However, status perceptions have a greater leveraging power in satisfaction when observability of preferential treatment is high.Originality/valueThe results of this study have significant implications for service firms with loyalty programs and customer prioritization practices. By incorporating CSR into their loyalty programs, firms may be able to mitigate the negative bystander effect while maintaining the positive effects of preferential treatment on members’ service encounter satisfaction.
The development of the “Water Campaign”
Authors: Blanchette Lyne M.G. , van de Gaar Vivian M. , Raat Hein , French Jeff , Jansen Wilma 
Published: October 2016

Purpose
This paper aims to present a description of the development and implementation of a combined school- and community-based intervention for the prevention of overweight among children, using the combined methods of social marketing (SMk) and intervention mapping (IM).

Design/methodology/approach
The SMk total process planning (TPP) framework was used, a simple but robust framework that consists of five stages: scoping, development, implementation, evaluation and follow-up. In addition, IM tools were embedded in the development stage to strengthen the development element of the campaign.

Findings
The use of the SMk TPP framework led to the selection of one specific target segment and behaviour. IM tools helped to select the most important and modifiable determinants and behaviours in the target segment, as well as to select and appropriately apply theoretical methods for influencing determinant and behaviour change. The resulting “Water Campaign” was aimed at Turkish and Moroccan mothers and their 6-12-year-old-children (target segment). This intervention addresses the consumption of sugar-sweetened beverages through the promotion of tap water drinking (target behaviour). The systematic involvement of key stakeholders resulted in capacity-building and co-creation.

Originality/value
A key finding of the present work is that the SMk TPP framework and IM tools can be successfully combined in intervention development, helping to develop enhanced interventions. Combining these methods led to a theory-based and client-oriented intervention, which was directed at multiple ecological levels and which systematically involved key stakeholders. With this detailed description of the intervention development, this paper aims to assist other researchers and practitioners in their quest to develop better interventions.
Libraries and digital memory
Authors: Massis Bruce 
Published: October 2016

Purpose
The purpose of this column is to consider the role of libraries in an effort to preserve and protect a collective digital memory.

Design/methodology/approach
This paper addresses literature review and commentary on this topic that has been addressed by professionals, researchers and practitioners.

Findings
Libraries and library consortia will help go forward into the future and expand as trusted repositories where digital memory can be preserved and shared.

Originality/value
The value in exploring this topic is to examine the library environment for collection, storage and dissemination of digital information.
Manufacture of dry‐ and brine‐salted soft camel cheeses for the camel dairy industry
Authors: Konuspayeva Gaukhar , Camier Benedicte , Aleilawi Nasser , Al‐Shumeimyri Mohamed , Al‐Hammad Khalid , Algruin Khalid , Alshammari Fahad , Beaucher Eric , Faye Bernard 
Published: October 2016

Two experiments were conducted in a camel cheese study to (i) compare camel cheese to bovine cheese made from bovine milk standardised to simulate camel milk, and (ii) describe the technology for manufacture of dry (SCC‐D) and brine‐salted soft camel cheese (SCC‐B). Comparable cheese yield (camel: 7.4 ± 0.15, cow: 7.3 ± 0.55 kg/100 kg of milk) and levels of dry matter loss in whey were observed. Clotting time was 234 s for both cheeses which were made using thermophillic starters. Cheese yield was 9.31 ± 0.64 kg/100 kg with 425.6 ± 38.2 g/kg cheese dry matter for SCC‐D and 8.22 ± 0.90 kg/100 kg with 469 ± 73.8 g/kg dry matter for SCC‐B.
Theory‐based pharmacokinetics and pharmacodynamics of S‐ and R‐warfarin and effects on international normalized ratio: influence of body size, composition and genotype in cardiac surgery patients
Authors: Xue Ling , Holford Nick , Ding Xiao‐liang , Shen Zhen‐ya , Huang Chen‐rong , Zhang Hua , Zhang Jing‐jing , Guo Zhe‐ning , Xie Cheng , Zhou Ling , Chen Zhi‐yao , Liu Lin‐sheng , Miao Li‐yan 
Published: October 2016

AimsThe aims of this study are to apply a theory‐based mechanistic model to describe the pharmacokinetics (PK) and pharmacodynamics (PD) of S‐ and R‐warfarin.MethodsClinical data were obtained from 264 patients. Total concentrations for S‐ and R‐warfarin were measured by ultra‐high performance liquid tandem mass spectrometry. Genotypes were measured using pyrosequencing. A sequential population PK parameter with data method was used to describe the international normalized ratio (INR) time course. Data were analyzed with NONMEM. Model evaluation was based on parameter plausibility and prediction‐corrected visual predictive checks.ResultsWarfarin PK was described using a one‐compartment model. CYP2C9 *1/*3 genotype had reduced clearance for S‐warfarin, but increased clearance for R‐warfarin. The in vitro parameters for the relationship between prothrombin complex activity (PCA) and INR were markedly different (A = 0.560, B = 0.386) from the theory‐based values (A = 1, B = 0). There was a small difference between healthy subjects and patients. A sigmoid Emax PD model inhibiting PCA synthesis as a function of S‐warfarin concentration predicted INR. Small R‐warfarin effects was described by competitive antagonism of S‐warfarin inhibition. Patients with VKORC1 AA and CYP4F2 CC or CT genotypes had lower C50 for S‐warfarin.ConclusionA theory‐based PKPD model describes warfarin concentrations and clinical response. Expected PK and PD genotype effects were confirmed. The role of predicted fat free mass with theory‐based allometric scaling of PK parameters was identified. R‐warfarin had a minor effect compared with S‐warfarin on PCA synthesis. INR is predictable from 1/PCA in vivo.
Celastrol prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of rapamycin pathway
Authors: Zhang Ruijie , Zhang Nana , Zhang Hai , Liu Chunxiao , Dong Xiaoqing , Wang Xiaoxue , Zhu Yu , Xu Chong , Liu Lei , Yang Sijun , Huang Shile , Chen Long 
Published: October 2016

Background and PurposeIncreasing evidence has suggested cadmium (Cd), as an inducer of ROS, is a potential pathogenic factor in human neurodegenerative diseases. Thus, it is important to find effective interventions for Cd‐induced oxidative stress in the CNS. Here, we have studied the effects of celastrol, a plant‐derived triterpene, on ROS production and cell death in neuronal cells, induced by Cd.Experimental ApproachPC12, SH‐SY5Y cells and primary murine neurons were used to study celastrol neuroprotection against Cd‐poisoning. Cd‐induced changes in cell viability, apoptosis, ROS and AMP‐activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway in the cells were analysed by Trypan blue exclusion, DAPI and TUNEL staining, ROS imaging, immunofluorescence staining and Western blotting. Pharmacological and genetic approaches were employed to investigate the mechanisms underlying Cd neurotoxicity.ResultsCelastrol attenuated Cd‐induced apoptosis by suppressing Cd activation of mTOR, which was attributed to preventing Cd inactivation of AMPK. Inhibition of AMPK with compound C or expression of dominant negative AMPKα prevented celastrol from hindering Cd‐induced dephosphorylation of AMPKα, activation of mTOR and apoptosis. Inhibition of mTOR with rapamycin or knockdown of mTOR potentiated prevention by celastrol, of Cd‐induced phosphorylation of p70 S6 kinase 1/eukaryotic initiation factor 4E binding protein 1 and apoptosis. Celastrol attenuated Cd‐induced cell death by suppressing induction of mitochondrial ROS.Conclusions and ImplicationsCelastrol prevented the inactivation of AMPK by mitochondrial ROS, thus attenuating Cd‐induced mTOR activation and neuronal apoptosis. Celastrol may be a promising agent for prevention of Cd‐induced oxidative stress and neurodegenerative diseases.
CCND1‐BCL2Gene Network: A direct target of Amifostine in human acute megakaryocytic leukemia cells
Authors: Zhang Feng , Yang Bo , Zhang Kailiang , Hou Mei‐Ling , Lu Xue‐chun , Li Yu‐Xin 
Published: October 2016

Amifostine, 2‐(3‐aminopropyl) aminoethyl phosphorothioate, is a broad‐spectrum cytoprotective agent used to treat nuclear radiation and chemical weapon injuries. Recently, amifostine has been shown to have a profound biological influence on tumor cells. To examine the effects and mechanisms underlying the effects of amifostine on human acute megakaryocytic leukemia, we evaluated the efficacy of amifostine against Dami cells and observed a cell cycle arrest in G2/M phase. Amifostine treatment also induced cell apoptosis of Dami cells which corresponds to formal studies. Through whole‐genome microarray and bioinformatics analyses, we found that amifostine affected the gene expression ofCCND1, BCL2, andCASP3which revealed the mechanism amifostine acted on Dami cells. Thus,CCND1‐BCL2Gene Network is predicted to be a direct target of amifostine treating human acute megakaryocytic leukemia, which may provide a novel potential target for the therapy of several subtypes of humanAML.
A Capacity to Get Things Right: Gilbert Ryle on Knowledge
Authors: Kremer Michael 
Published: October 2016

AbstractGilbert Ryle's distinction between knowledge‐how and knowledge‐that faces a significant challenge: accounting for the unity of knowledge. Jason Stanley, an ‘intellectualist’ opponent of Ryle's, brings out this problem by arguing that Ryleans must treat ‘know’ as an ambiguous word and must distinguish knowledge proper from knowledge‐how, which is ‘knowledge’ only so‐called. I develop the challenge and show that underlying Ryle's distinction is a unified vision of knowledge as ‘a capacity to get things right’, covering both knowledge‐how and knowledge‐that. I show how Ryle specifies the general notion into knowledge‐how and knowledge‐that and discuss the mutual interdependence exhibited by the two forms of knowledge. Ryle's positive view of knowledge, properly understood, emerges as an important, neglected, alternative which should be brought back into the ongoing conversation about practical and theoretical knowledge.
Setting accessibility preferences about learning objects within adaptive elearning systems: User experience and organizational aspects
Authors: Rodriguez‐Ascaso Alejandro , Boticario Jesús G. , Finat Cecile , Petrie Helen 
Published: October 2016

AbstractHigher and further education providers are facing the challenge of supporting the interaction needs of an increasing number of students who feature accessibility preferences to use both elearning contents and services. In the next future, we can expect that, within adaptive elearning systems, both automatic and manual procedures will interoperate to elicit users' interaction needs for ensuring accessibility. In this paper, we report findings from the user experience with the self‐assessment of interaction needs, as part of a content personalization system, which tackles possible mismatches in the interaction between the user and the learning objects. All stakeholders involved in providing this service along with intended user groups (students with visual, auditory or mobility impairments, and without impairments) participated in the evaluation with over 100 users described in this paper. From the evaluation, results follow that our approach allows students to self‐assess and report adequately their interaction preferences. Furthermore, the paper describes findings of interest and open issues about how massive online courses may address the accessibility needs of an increasing number of elearning users.
Range shifts or extinction? Ancient DNA and distribution modelling reveal past and future responses to climate warming in cold‐adapted birds
Authors: Lagerholm Vendela K. , Sandoval‐Castellanos Edson , Vaniscotte Amélie , Potapova Olga R. , Tomek Teresa , Bochenski Zbigniew M. , Shepherd Paul , Barton Nick , Van Dyck ‎Marie‐Claire , Miller Rebecca , Höglund ‎Jacob , Yoccoz Nigel G. , Dalén Love , Stewart John R. 
Published: October 2016

AbstractGlobal warming is predicted to cause substantial habitat rearrangements, with the most severe effects expected to occur in high‐latitude biomes. However, one major uncertainty is whether species will be able to shift their ranges to keep pace with climate‐driven environmental changes. Many recent studies on mammals have shown that past range contractions have been associated with local extinctions rather than survival by habitat tracking. Here, we have used an interdisciplinary approach that combines ancient DNA techniques, coalescent simulations and species distribution modelling, to investigate how two common cold‐adapted bird species, willow and rock ptarmigan (Lagopus lagopus and Lagopus muta), respond to long‐term climate warming. Contrary to previous findings in mammals, we demonstrate a genetic continuity in Europe over the last 20 millennia. Results from back‐casted species distribution models suggest that this continuity may have been facilitated by uninterrupted habitat availability and potentially also the greater dispersal ability of birds. However, our predictions show that in the near future, some isolated regions will have little suitable habitat left, implying a future decrease in local populations at a scale unprecedented since the last glacial maximum.
CD4+ and CD8+ T‐cell immunity to Dengue – lessons for the study of Zika virus
Authors: Rivino Laura , Lim Mei Qiu 
Published: October 2016

SummaryDengue virus (DENV) and Zika virus (ZIKV) are rapidly emerging mosquito‐borne flaviviruses that represent a public health concern. Understanding host protective immunity to these viruses is critical for the design of optimal vaccines. Over a decade of research has highlighted a significant contribution of the T‐cell response to both protection and/or disease enhancement during DENV infection, the latter being mainly associated with sub‐optimal cross‐reactive T‐cell responses during secondary infections. Phase IIb/III clinical trials of the first licensed tetravalent dengue vaccine highlight increased vaccine efficacy in dengue‐immune as opposed to dengue‐naive vaccinees, suggesting a possible immunoprotective role of pre‐existing DENV‐specific T cells that are boosted upon vaccination. No vaccine is available for ZIKV and little is known about the T‐cell response to this virus. ZIKV and DENV are closely related viruses with a sequence identity ranging from 44% and 56% for the structural proteins capsid and envelope to 68% for the more conserved non‐structural proteins NS3/NS5, which represent the main targets of the CD4+ and CD8+ T‐cell response to DENV, respectively. In this review we discuss our current knowledge of T‐cell immunity to DENV and what it can teach us for the study of ZIKV. The extent of T‐cell cross‐reactivity towards ZIKV of pre‐existing DENV‐specific memory T cells and its potential impact on protective immunity and/or immunopathology will also be discussed.
A New Species of Centrohelid Heliozoan Acanthocystis amura n. sp. Isolated From Two Remote Locations in Russia
Authors: Zlatogursky Vasily V. , Gerasimova Elena A. , Plotnikov Andrey O. 
Published: October 2016

AbstractA new species of centrohelid heliozoan Acanthocystis amura from the Amur River, the Far East of Russia was studied with light‐ and electron microscopy. Acanthocystis amura has simple oval plate scales (1.2–2.6 × 1.0–1.8 μm) with an axial thickening and a thin border as well as two types of spine scales. The spine scales of type 1 were 1.3–4.8 μm long and had four small hooks on their tips. The spine scales of type 2 were shorter, 1.0–3.6 μm long and had four teeth at the distal end. The morphology of A. amura resembles that of Acanthocystis quadrifurca. They both have similar spine scales but their plate scales are completely different. Acanthocystis valdiviense differs from the new species in absence of hook‐bearing scales. Molecular phylogeny based on 18S rDNA consistently placed A. amura into Acanthocystis nichollsi/Acanthocystis costata clade, but relationships between those three species were not resolved. Morphology of another centrohelid strain from another location (the South Urals) has been compared with that of the original strain and few minor differences in size characteristics of the scales have been revealed.
Differential expression of thioredoxin binding protein‐2/Txnip in human placenta: Possible involvement of hypoxia in its suppression during early pregnancy
Authors: Mogami Haruta , Yura Shigeo , Kondoh Eiji , Masutani Hiroshi , Yodoi Junji , Konishi Ikuo 
Published: October 2016

AbstractAimThioredoxin binding protein‐2 (TBP‐2), which is identical to thioredoxin interacting protein (Txnip), controls cellular proliferation and differentiation. The aim of the present study was to compare TBP‐2 protein and mRNA expression in human placenta during the three trimesters of pregnancy and to investigate the role of hypoxia in the change of these expressions in placental tissue. A secondary objective was to determine the gene expression of peroxisome proliferator‐activated receptors (PPARs) in TBP‐2 deficient placenta using TBP‐2 gene disrupted mice (TBP‐2−/−).MethodsProtein and mRNA expression of TBP‐2 in human placenta from each trimester were analyzed by immunohistochemistry, Western blots, and by quantitative reverse‐transcriptase‐polymerase chain reaction. The effect of hypoxia on TBP‐2 expression was tested using an explant culture of human placenta. In TBP‐2−/− mouse placenta, we detected PPAR mRNA expression.ResultsTBP‐2 was located in syncytiotrophoblasts and cytotrophoblasts, and also in the endothelium in human placenta. Its expression in the placenta was low in the first trimester, and increased in the second and third trimesters. Hypoxia decreased TBP‐2 mRNA and protein expression in human placental explant culture. In TBP‐2−/− mice, placental mRNA levels of PPARα and γ were significantly suppressed compared with those in wild‐type mice.ConclusionHypoxia suppresses TBP‐2 gene expression, which may ultimately alter placental development.
Treatment of total pelvic organ prolapse using a whole biological patch: A pilot study of 17 patients
Authors: Liang Xianghua , Zhang Lili , Lv Yanwei 
Published: October 2016

AbstractAimA complete and non‐splice porcine small‐intestine submucosa (SIS) patch was used for total pelvic anatomical repair of organ prolapse.MethodsThis study included a total of 17 patients with severe total pelvic organ prolapse, including five patients with combined stress urinary incontinence (SUI). Panhysterectomy was performed, and then a porcine SIS patch was placed on the anterior (posterior) vaginal wall. The top of the vaginal wall was moved to the corresponding side of the vaginal wall, and the patch was sutured to bilateral uterosacral ligaments, the sacrospinous ligament, and arcus tendineus fasciae pelvis. SUI was addressed at the same time. ‘Failure’ was defined as anterior or posterior wall prolapse beyond the hymen.ResultsThe mean follow‐up duration was 11.6 ± 7.45 months (2–24 months). No symptom recurrence was observed in the five patients with combined SUI. One patient who underwent porcine SIS patch placement on the posterior wall experienced stage II anterior vaginal wall prolapse after surgery. The vaginal wall and fornix of the remaining patients with patches were restored to stable anatomical positions (92.85%). No organ damage, infection, erosion, or rejection was observed, and no blood transfusion was necessary.ConclusionThis study is the first to implement total pelvic anatomical repair using a complete and non‐splice SIS. Our results suggest that this new surgical method is safe and can achieve satisfactory therapeutic effects, especially for patients with combined SUI.
Multispecies genetic structure and hybridization in the Betula genus across Eurasia
Authors: Tsuda Yoshiaki , Semerikov Vladimir , Sebastiani Federico , Vendramin Giovanni Giuseppe , Lascoux Martin 
Published: October 2016

AbstractBoreal and cool temperate forests are the major land cover of northern Eurasia, and information about continental‐scale genetic structure and past demographic history of forest species is important from an evolutionary perspective and has conservation implications. However, although many population genetic studies of forest tree species have been conducted in Europe or Eastern Asia, continental‐scale genetic structure and past demographic history remain poorly known. Here, we focus on the birch genus Betula, which is commonly distributed in boreal and cool temperate forests, and examine 129 populations of two tetraploid and four diploid species collected from Iceland to Japan. All individuals were genotyped at seven to 18 nuclear simple sequence repeats (nSSRs). Pairwise among the six species ranged from 0.285 to 0.903, and genetic differentiation among them was clear. structure analysis suggested that Betula pubescens is an allotetraploid and one of the parental species was Betula pendula. In both species pairs of B. pendula and B. plathyphylla, and B. pubescens and B. ermanii, genetic diversity was highest in central Siberia. A hybrid zone was detected around Lake Baikal for eastern and western species pairs regardless of ploidy level. Approximate Bayesian computation suggested that the divergence of B. pendula and B. platyphylla occurred around the beginning of the last ice age (36 300 years BP, 95% CI: 15 330–92 700) and hybridization between them was inferred to have occurred after the last glacial maximum (1614 years BP, 95% CI: 561–4710), with B. pendula providing a higher contribution to hybrids.