bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of single plane and biplane angiography systems for mechanical thrombectomy for acute ischemic stroke: a systematic review and meta-analysis
Authors: Orscelik Atakan , Bilgin Cem , Cortese Jonathan , Cayme Joshua J , Zandpazandi Sara , Senol Yigit Can , Musmar Basel , Ghozy Sherief , Bayraktar Esref Alperen , Beizavi Zahra , Brinjikji Waleed , Kallmes David F 
Published: October 2024

BackgroundThe choice of angiography system could influence the outcomes of mechanical thrombectomy (MT) in the treatment of acute ischemic stroke (AIS), but its impact is not yet well understood. This study aims to compare the clinical and technical outcomes of MT performed with single plane versus biplane angiography systems.MethodWe conducted a systematic review and meta-analysis, following PRISMA guidelines, by searching PubMed, Embase, Web of Science, and Scopus to include studies on patients with AIS who underwent MT with either single plane or biplane angiography up to May 4, 2024. The primary outcome was a favorable outcome defined as a modified Rankin Scale (mRS) score of 0–2 at 90 days after the procedure. Data were analyzed using a random-effects model and heterogeneity was assessed using the I2test and Q statistics.ResultsFive studies with a total of 1562 patients were analyzed. Of these, 68.4% were treated with biplane systems and 31.6% with single plane systems. Single plane angiography was associated with a significantly higher rate of favorable outcomes (OR 1.43; 95% CI 1.13 to 1.80; P<0.01). There were no significant differences in successful recanalization, periprocedural complications, procedure time, total fluoroscopy time, or contrast volume between the two systems.ConclusionWhile single plane angiography systems may offer slightly better outcomes in MT for AIS, both systems appear equally effective in most clinical and technical perspectives, suggesting that system selection may be more dependent on availability and procedural requirements rather than inherent superiority. Our findings may encourage clinicians to use single-plane angiography in settings where the biplane angiography suite availability is limited, but it should be noted that this observation may have been influenced by selection bias, particularly since the larger studies included in our meta-analysis did not observe this effect in adjusted analyses for potential confounder factors.
Characterisation of myeloid cells in circulation and synovial fluid of patients with psoriatic arthritis
Authors: Fine Noah , Glogauer Michael , Chandran Vinod , Oikonomopoulou Katerina 
Published: October 2024

ObjectivePsoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Adding to studies focused on the role of T cells and macrophages, we sought to investigate the systemic activation of leukocytes in PsA.MethodsWe assessed the activation state of leukocyte populations, including polymorphonuclear neutrophils (PMNs) and monocyte/macrophages, in blood and synovial fluid (SF) by multicolour flow cytometry. We also evaluated the correlation between leukocyte numbers and expression of activation markers with disease activity parameters.ResultsSF PMNs showed an elevated activation state compared with blood PMNs, but a reduced activation state compared with oral PMNs of non-arthritic controls. In vitro stimulation caused SF PMNs to become further activated, demonstrating that they retain a reserve capacity for activation in response to specific triggers. We found significant variability between patients in the expression of SF PMN CD activation markers, indicating a range of possible activation states across patients. However, PMN CD marker expression remained consistent over two sequential visits in a subset of patients, indicating patient-specific distinct inflammatory states during flares. We further found that markers of disease activity increased with elevated SF macrophage numbers. Expression of several CD markers on blood or SF cells, for example, PMN expression of the high-affinity Fc-receptor CD64, correlated with disease activity markers, including pain score and Disease Activity in Psoriatic Arthritis score.ConclusionThese preliminary findings support a potential role for surface antigens on PMNs and monocytes/macrophages as prognostic or disease activity monitoring tools.
Survival of antimicrobial resistant Salmonella Heidelberg inoculated into microcosms of fresh pine wood shavings for broiler litter
Authors: Oladeinde Adelumola , Cook Kimberly , Rehman Attiq , Carrillo Catherine D. , Woyda Reed , Wiersma Crystal , Abdo Zaid , Johnson Jasmine , Bosch Anna Marie , Rothrock Michael , Diarra Moussa S. 
Published: October 2024

This study characterized the genome of three Salmonella enterica serovar Heidelberg ( S. Heidelberg) strains with different antimicrobial resistance (AMR) profile that were inoculated as a cocktail into fresh pine wood shavings (PWS). The strains were isolated from feces (SH-AAFC), carcass (SH-ARS), and thigh (SH-FSIS) of broiler chicken. SH-AAFC harbored an antimicrobial resistant gene (ARG) blaCMY-2 on an IncI1 plasmid while SH-FSIS harbored multiple ARGs ( floR, cmlA1, tet( A), blaTEM-1B, ant( 2″) -Ia, aph( 6) -Id, aph( 3″) -Ib, and sul2) on an IncC plasmid. SH-ARS was pan-susceptible. The die-off of Salmonella was determined at days 0, 1, 7, 14, and 21. Antibiotic susceptibility tests and whole genome sequencing were performed on 77 isolates. At 21 days post-inoculation, Salmonella abundance decreased by 4.4 Log10 CFU/g with the water activity of PWS being correlated with Salmonella survival. SH-AAFC clonal populations survived longer in PWS than SH-FSIS and SH-ARS populations. SH-AAFC clones persisting in litter carried higher copy number of Col plasmids than their ancestors, while some SH-ARS clones acquired a lysogenic bacteriophage from SH-FSIS populations. These results suggest that mobile genetic determinants such as plasmids (which could carry ARGs) and bacteriophage plays roles in the persistence of S. Heidelberg in the PWS used as broiler litter. Highlights S. Heidelberg survived up to 21 days in PWS which is often used as broiler bedding. S. Heidelberg abundance and survival was correlated with the water activity of PWS. S. Heidelberg strains that carried higher copy numbers of small Col plasmids were the dominant strains isolated from PWS at later time points. S. Heidelberg strains harboring transmissible plasmid carrying AmpC-like beta-lactamase gene persisted longer in PWS without antibiotic pressures for AMR.
Enhancing iron and zinc uptake in spring wheat through commercial arbuscular mycorrhizal fungi inoculation under different soil phosphorus addition levels
Authors: Gao Xiaopeng , Zhang Kai 
Published: October 2024

Improving the concentrations and bioavailability of micronutrients, especially iron (Fe) and zinc (Zn), in crop grains is important to alleviate their deficiencies in humans. Inoculating crops with arbuscular mycorrhizal fungi (AMF) can potentially enhance soil nutrient supply and crop yield, but the effectiveness is influenced by soil factors, particularly soil phosphorus (P) availability. A greenhouse pot experiment was conducted to evaluate the effect of a commercial AMF product on spring wheat ( Triticum aestivum L.) yield and grain concentrations of Zn and Fe under different soil P addition levels (0, 5, and 20 mg P kg–1 dry soil). Results showed that AMF inoculation significantly increased root colonization rate of wheat across all P addition levels. Wheat growth, as evidenced by dry weights of shoot and grain, was significantly enhanced by AMF and high P addition treatments. AMF inoculation did not affect grain Zn concentration, but significantly increased grain Fe concentration compared to the un-inoculated control. As expected, P addition resulted in a significant reduction in grain concentrations of Fe and Zn, primarily due to a growth dilution effect. An integrated analysis using the radar plot concludes that AMF inoculation is most effective in increasing crop yield and grain micronutrient concentrations when soil P levels are low. Importantly, while adequate P supply is crucial for maintaining crop productivity, it may decrease grain micronutrient availability without complementary strategies.
Gravastars formation with back-reaction effects from extended general relativity
Authors: Bellini Mauricio 
Published: October 2024

AbstractUsing an extended theory of General Relativity that incorporates normalized relativistic velocities, where the boundary terms in the varied Einstein–Hilbert action are considered. Within this context, I investigate the dynamic evolution of a collapsing spherical system characterized by a metric with spatial curvature and variable time-scale, aiming to describe the process of Gravastar formation. To illustrate the system’s dynamics, I analyze a power-law collapsing scenario and derive the equation of state for both cases, with and without geometrical perturbations. In particular, I derive the equation of state, incorporating back-reaction effects related with the boundary terms of the varied Einstein–Hilbert action.
Vetoing all the Higgs imposters in $$H\rightarrow \ell ^-\ell ^+ Z$$
Authors: Choi Seong Youl , Jeong Jaehoon , Kang Dong Woo 
Published: October 2024

AbstractWe develop an effective and methodical algorithm for the construction of general covariant four-point $$H\ell \ell Z$$

H
ℓ
ℓ
Z

vertices, accommodating leptons $$\ell =e, \mu $$

ℓ
=
e
,
μ

, and designed to handle a boson H of any integer spin, not merely confined to spins up to 2. While our numerical analysis assumes the H-boson mass to be $$m_H=125\,\textrm{GeV}$$

m
H

=
125

GeV

, the analytical framework we propose is versatile, enabling the examination of various mass as well as spin scenarios. These meticulously devised general covariant four-point $$H\ell \ell Z$$

H
ℓ
ℓ
Z

vertices are pivotal in vetoing all the imposters of the Standard Model Higgs boson holding the spin-0 and even-parity quantum numbers, especially in one of its primary decay channels, the three-body decay process $$H\rightarrow \ell ^-\ell ^+ Z$$

H
→

ℓ
-

ℓ
+

Z

, observable at the Large Hadron Collider. Our innovative strategy encompasses the analysis of all the effectively allowed scenarios, extending beyond the limitations of previous investigations on the Higgs spin and parity determinations in the decay $$H \rightarrow \ell ^-\ell ^+ Z$$

H
→

ℓ
-

ℓ
+

Z

. Based on the significantly expanded scheme, we demonstrate that the Higgs boson imposter of any spin and parity can be definitively vetoed by leveraging angular and invariant mass distributions focusing on threshold effects. Even though achieving such conclusive results in practical and exhaustive analyses may necessitate high event rates, especially in the spin-0 contact-interaction case.
Latvian Quantum Finite State Automata for Unary Languages
Authors: Mereghetti Carlo , Palano Beatrice , Raucci Priscilla 
Published: October 2024

We design Latvian quantum finite state automata (LQFAs) recognizing unary regular languages with isolated cut point [Formula: see text]. From an architectural viewpoint, we suitably combine two LQFAs recognizing with isolated cut point, respectively, the finite part and the ultimately periodic part any given unary regular language [Formula: see text] consists of. In particular, both these LQFAs incorporate a sub-module discriminating strings on the basis of their length. Both the number of basis states and the isolation around the cut point of the resulting LQFAs for [Formula: see text] exponentially depend on the size of the minimal deterministic finite state automaton for [Formula: see text]. Moreover, the recognition of [Formula: see text] tends to becoming deterministic as the number of the basis states employed in the length-discriminating sub-module grows.
Detecting Hidden Voice Recorders via ADC Electromagnetic Radiation
Authors: Zhou Ruochen , Ji Xiaoyu , Chen Han , Yan Chen , Xu Wenyuan 
Published: October 2024

Unauthorized covert voice recording presents a significant threat to privacy-sensitive scenarios, such as confidential meetings and private conversations. Due to their miniaturization and disguise characteristics, hidden voice recorders are difficult to notice. In this article, we present
DeHiREC
, the first proof-of-concept system capable of detecting offline hidden voice recorders from their electromagnetic radiations (EMR). We first characterize the unique patterns of the emanated EMR signals and then locate the EMR source, i.e., the analog-to-digital converter module embedded in the mixed signal system-on-chips. Since these unintentional EMR signals can be extremely noisy and weak, accurately detecting them can be challenging. To address this challenge, we design an EMR Catalyzing method to actively stimulate the EMR signals and then employ an adaptive-folding algorithm to improve the signal-to-noise ratio of the sensed EMRs. We evaluate the performance of
DeHiREC
on 18 commercial voice recorders under various impacts, including interference from other devices. Experimental results reveal that
DeHiREC
is effective in detecting all 18 voice recorders and achieves an overall success rate of 94.72% and a recall rate of 92.03% at a distance of 0.2 m.
Toward a Better Understanding of Statistical Significance and p Values in Nursing
Authors: Holmberg Christopher 
Published: October 2024

Background: Nursing aims to rely on the best evidence, yet nurses frequently struggle with statistics, impeding the integration of research into practice. The misuse of statistical significance and p values is a pervasive issue, widely debated across disciplines but often overlooked in nursing.Objective: This study seeks to elucidate key arguments surrounding the misuse of p values, assess their relevance to nursing, and propose recommendations for improvement.Approach: Conducting a critical literature review on the interpretation and reporting of statistical significance and its practical implications among nurses, nursing students, and scholars.Results: The literature reveals widespread misunderstandings of probability concepts in classical statistics, leading to the misuse of p values. Some scholars propose abandoning p values altogether due to these challenges. Rather than dismissing p values, this article provides insights into their historical context and proper application. Recommendations are offered for accurately interpreting results and integrating supplementary metrics. Fostering statistical competencies already at the undergraduate level can enhance statistical literacy and alleviate statistics anxiety among nursing students, a prevalent issue. Early exposure to statistical methods in nursing education empowers nurses to actively engage in research. Additional recommendations include preregistering analysis plans to mitigate publication bias and exploring alternative approaches such as Bayesian methods.Conclusions: While p values serve as a valuable tool for preliminary assessment against randomness in nursing research, their widespread misunderstanding necessitates multiple measures for accurate interpretation and understanding of statistical significance. It is imperative for nurse educators and researchers to incorporate these recommendations into their practices.
Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes
Authors: Kuett Laura , Bollhagen Alina , Tietscher Sandra , Sobottka Bettina , Eling Nils , Varga Zsuzsanna , Moch Holger , de Souza Natalie , Bodenmiller Bernd 
Published: October 2024

Abstract
Breast cancer is the most commonly diagnosed cancer in women, with distant metastasis being the main cause of breast cancer–related deaths. Elucidating the changes in the tumor and immune ecosystems that are associated with metastatic disease is essential to improve understanding and ultimately treatment of metastasis. Here, we developed an in-depth, spatially resolved single-cell atlas of the phenotypic diversity of tumor and immune cells in primary human breast tumors and matched distant metastases, using imaging mass cytometry to analyze a total of 75 unique antibody targets. Although the same tumor cell phenotypes were typically present in primary tumors and metastatic sites, suggesting a strong founder effect of the primary tumor, their proportions varied between matched samples. Notably, the metastatic site did not influence tumor phenotype composition, except for the brain. Metastatic sites exhibited a lower number of immune cells overall but had a higher proportion of myeloid cells as well as exhausted and cytotoxic T cells. Myeloid cells showed distinct tissue-specific compositional signatures and increased presence of potentially matrix remodeling phenotypes in metastatic sites. This analysis of tumor and immune cell phenotypic composition of metastatic breast cancer highlights the heterogeneity of the disease within patients and across distant metastatic sites, indicating myeloid cells as the predominant immune modulators that could potentially be targeted at these sites.
Significance: Multiplex imaging analysis of matched primary and metastatic breast tumors provides a phenotypic and spatial map of tumor microenvironments, revealing similar compositions of cancer cells and divergent immunologic features between matched samples.
AKT and the Hallmarks of Cancer
Authors: Sementino Eleonora , Hassan Dalal , Bellacosa Alfonso , Testa Joseph R. 
Published: October 2024

Abstract
Nearly a quarter century ago, Hanahan and Weinberg conceived six unifying principles explaining how normal cells transform into malignant tumors. Their provisional set of biological capabilities acquired during tumor development—cancer hallmarks—would evolve to 14 tenets as knowledge of cancer genomes, molecular mechanisms, and the tumor microenvironment expanded, most recently adding four emerging enabling characteristics: phenotypic plasticity, epigenetic reprogramming, polymorphic microbiomes, and senescent cells. AKT kinases are critical signaling molecules that regulate cellular physiology upon receptor tyrosine kinases and PI3K activation. The complex branching of the AKT signaling network involves several critical downstream nodes that significantly magnify its functional impact, such that nearly every organ system and cell in the body may be affected by AKT activity. Conversely, tumor-intrinsic dysregulation of AKT can have numerous adverse cellular and pathologic ramifications, particularly in oncogenesis, as multiple tumor suppressors and oncogenic proteins regulate AKT signaling. Herein, we review the mounting evidence implicating the AKT pathway in the aggregate of currently recognized hallmarks of cancer underlying the complexities of human malignant diseases. The challenges, recent successes, and likely areas for exciting future advances in targeting this complex pathway are also discussed.
Intra- and Extrahepatic Cholangiocarcinomas Display Differing Sensitivities to NK Cell Lysis and Modulate NK Cell Function through Shared and Distinct Pathways
Authors: Nguyen Ngan , Henrich Ian C. 
Published: October 2024

Abstract
Cholangiocarcinoma (CCA) is a rare cancer that arises from the bile duct and is broadly classified by the location of the tumor as either intrahepatic cholangiocarcinoma (iCCA) or extrahepatic cholangiocarcinoma (eCCA). Immunotherapy has revolutionized cancer treatment, yet its utility in CCA has been limited as the tumor microenvironment (TME) in CCA is poorly understood compared with other common cancers. Utilizing previously published transcriptome data, our reanalysis has revealed that CCA has one of the highest relative levels of NK cells, a potent cytotoxic immune cell, compared with other cancers. However, despite iCCA and eCCA having comparable relative levels of NK infiltration, NK cell infiltration only correlated with survival in patients with eCCA. Our subsequent investigation revealed that although iCCA and eCCA profoundly altered NK activity, eCCA had a significantly reduced impact on NK functionality. Whereas iCCA was resistant to long-term NK coculture, eCCA was markedly more sensitive. Moreover, although both iCCA and eCCA dysregulated key NK-activating receptors, eCCA coculture did not impact NKp30 nor NKp44 expression. Furthermore, tumor transcriptome analysis of NKHigh CCA samples revealed a modulation of multiple immune and nonimmune cell types within the TME.
Implications: These studies are the first to investigate how iCCA and eCCA impact NK cell functionality through shared and distinct mechanisms and how elevated NK cell infiltration could shape the CCA TME in a subtype-dependent manner.
Associations Between Vision and Hearing Impairment and Cardiovascular Diseases: A Longitudinal Cohort of Middle‐Aged and Older Adults in China
Authors: He Jie , Tang Xiaoyu , Jiang Minglan , Zheng Xiaowei 
Published: October 2024

Background
Based on the severity of cardiovascular disease (CVD) and sensory impairment in China and the lack of research on this, the aims of our study were to assess the impact of hearing impairment (HI), visual impairment (VI), and concurrent HI and VI (termed dual sensory impairment) on CVD in elderly people, based on a representative sample of China.

Methods and Results
We used data from the CHARLS (China Health and Retirement Longitudinal Study) for our survey of 11 332 participants. We calculated hazard ratios (HRs) and 95% 95% CIs for CVD, stroke, and cardiac events by using Cox proportional hazards models. HI and VI status were collected through self‐reported questions. During the 7‐year follow‐up, a total of 2156 participants experienced CVD (including 745 stroke and 1605 cardiac events). Compared with the reference, individuals with VI had higher risk of CVD (HR, 1.24 [95% CI, 1.09–1.40]). Individuals with HI also had higher risk of CVD than those without HI (HR, 1.20 [95% CI, 1.09–1.33]). Compared with participants without VI and HI, individuals with dual sensory impairment had a 1.35‐fold increased risk of CVD (HR, 1.35 [95% CI, 1.16–1.57]). In addition, individuals with dual sensory impairment also had increased risk of stroke and cardiac events.

Conclusions
Our study shows that HI and VI have a combined effect on the incidence of CVD. Based on the high prevalence of CVD around the world, early detection of sensory disorders and the adoption of appropriate measures may contribute to prevent CVD and reduce the burden of clinical diagnosis and treatment of CVD.