bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of overall life satisfaction and its association with breast diseases in Chinese women
Authors: Bai Aili , Li Haixin , Huang Yubei , Liu Xueou , Gao Ying , Wang Peishan , Dai Hongji , Song Fengju , Hao Xishan , Chen Kexin 
Published: December 2015

AbstractTo investigate the association between overall life satisfaction and healthy lifestyle, knowledge of breast cancer, physical examination, and detection rate of breast cancer and benign breast disease in Chinese women. In a multicentered breast disease screening program in China, we enrolled 33,057 women aged 45–65 years without prior diagnosis of breast cancer. After completing an epidemiological questionnaire, all participants were examined by clinical breast examination, breast ultrasound, and mammography independently. All breast cancer cases and a selected sample of benign breast diseases were confirmed pathologically. Univariate and multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association between life satisfaction and lifestyle, knowledge of breast cancer, physical examination, and detection rate of breast diseases. Overall life satisfaction was positively associated with women's healthy lifestyle. Compared with less satisfied women, satisfied women were less likely to be smokers (OR = 0.54; 95% CI: 0.47–0.62), have more exercise (OR = 1.49; 95% CI: 1.26–1.75), eat less fried (OR = 0.60; 95% CI: 0.50–0.71), smoked (OR = 0.54, 95% CI: 0.47–0.63), pickled (OR = 0.66, 95% CI: 0.55–0.79), and grilled (OR = 0.63, 95% CI: 0.54–0.74) foods. Satisfied women were more likely to have knowledge of breast cancer (OR = 1.48, 95% CI: 1.29–1.70), and have regular physical examinations (OR = 1.11, 95% CI: 1.01–1.12). Compared to less satisfied women, we found significantly lower detection rate of benign breast diseases (OR = 0.90, 95% CI: 0.82–0.99), and lower but nonsignificant detection rate of breast cancer (OR = 0.66, 95% CI: 0.35–1.25) in satisfied women. Women with a higher overall life satisfaction are more likely to have healthy lifestyle, knowledge of breast cancer, and regular physical examination, thus resulting in a lower detection rate of breast diseases in screening.
Perovskite as a Cathode Material: A Review of its Role in Solid‐Oxide Fuel Cell Technology
Authors: Jun Areum , Kim Junyoung , Shin Jeeyoung , Kim Guntae 
Published: December 2015

AbstractSolid oxide fuel cells (SOFCs) are characterized by low pollution, and are therefore the best alternative both for distributed energy sources and large‐scale integration. Fuel flexibility, including hydrocarbons, is the main advantage of SOFCs. For the successful introduction of SOFC technology to the market, reduced temperature operation at 600–800 °C is an essential factor. One of the important issues for the reduced temperature operation is to get rid of stability issues while maintaining a certain level of performance. Therefore, the development of alternative materials such as perovskite cathodes is essential to create not only practically acceptable performance, but also to ensure the highly reliable and stable operation of the resulting SOFCs. This review provides a critical and comprehensive survey on the perovskite materials for SOFC cathodes and suggests effective and stable alternatives for the realiable operation of SOFCs.
Synthesis and Electrochemistry of Na2.5(Fe1−yMny)1.75(SO4)3 Solid Solutions for Na‐Ion Batteries
Authors: Wei Suhao , Mortemard de Boisse Benoit , Oyama Gyosuke , Nishimura Shin‐ichi , Yamada Atsuo 
Published: December 2015

AbstractNa2+2xFe2−x(SO4)3 was recently reported as a promising cathode material for Na‐ion batteries with high voltage generation (3.8 V vs. Na/Na+), high energy density, and extreme high‐rate operation, making it competitive to lithium battery cathodes. Following our identification of the narrow off‐stoichiometric region in Na2+2xFe2−x(SO4)3 solid solutions (x around 0.25), we report here the effect of Mn substitution in Na2.5(Fe1−yMny)1.75(SO4)3 (y=0, 0.25, 0.5, 0.75, and 1.0) solid solutions when increasing the voltage of the Fe3+/Fe2+ redox couple, but with a simple capacity decrease, owing to the entire Mn2+ inactivity.
Targeting Innate Immunity with dsRNA‐Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells
Authors: Ultimo Amelia , Giménez Cristina , Bartovsky Pavel , Aznar Elena , Sancenón Félix , Marcos M. Dolores , Amorós Pedro , Bernardo Ana R. , Martínez‐Máñez Ramón , Jiménez‐Lara Ana M. , Murguía José R. 
Published: December 2015

AbstractWe describe herein a Toll‐like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK‐BR‐3 breast carcinoma cells. Our results show that poly(I:C)‐conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA–TLR3 interaction. Such interaction also triggered apoptotic pathways in SK‐BR‐3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles′ mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
Single‐Component Phosphinous Acid Ruthenium(II) Catalysts for Versatile C−H Activation by Metal–Ligand Cooperation
Authors: Zell Daniel , Warratz Svenja , Gelman Dmitri , Garden Simon J. , Ackermann Lutz 
Published: December 2015

AbstractWell‐defined ruthenium(II) phosphinous acid (PA) complexes enabled chemo‐, site‐, and diastereoselective C−H functionalization of arenes and alkenes with ample scope. The outstanding catalytic activity was reflected by catalyst loadings as low as 0.75 mol %, and the most step‐economical access reported to date to angiotensin II receptor antagonist blockbuster drugs. Mechanistic studies indicated a kinetically relevant C−X cleavage by a single‐electron transfer (SET)‐type elementary process, and provided evidence for a PA‐assisted C−H ruthenation step.
A New Family of Anionic FeIII Spin Crossover Complexes Featuring a Weak‐Field N2O4 Coordination Octahedron
Authors: Takahashi Kazuyuki , Kawamukai Kiko , Okai Mitsunobu , Mochida Tomoyuki , Sakurai Takahiro , Ohta Hitoshi , Yamamoto Takashi , Einaga Yasuaki , Shiota Yoshihito , Yoshizawa Kazunari 
Published: December 2015

AbstractUnprecedented anionic FeIII spin crossover (SCO) complexes involving a weak‐field O,N,O‐tridentate ligand were discovered. The SCO transition was evidenced by the temperature variations in magnetic susceptibility, Mössbauer spectrum, and coordination structure. The DFT calculations suggested that larger coefficients on the azo group in the HOMO−1 of a ligand might contribute to the enhancement of a ligand‐field splitting energy. The present anionic SCO complex also exhibited the light‐ induced excited‐spin‐state trapping effect.
Structure–Activity Relationships of JMV4463, a Vectorized Cathepsin D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA‐Based Vector
Authors: Vezenkov Lubomir L. , Sanchez Clément A. , Bellet Virginie , Martin Vincent , Maynadier Marie , Bettache Nadir , Lisowski Vincent , Martinez Jean , Garcia Marcel , Amblard Muriel , Hernandez Jean‐François 
Published: December 2015

AbstractCathepsin D (CathD) is overexpressed and secreted by several solid tumors and stimulates their growth, the mechanism of which is still not understood. In this context, the pepstatin bioconjugate JMV4463 [Ac‐arg‐O2Oc‐(Val)3‐Sta‐Ala‐Sta‐(AMPA)4‐NH2; O2Oc=8‐amino‐3,6‐dioxaoctanoyl, Sta=statine, AMPA=ortho‐aminomethylphenylacetyl], containing a new kind of cell‐penetrating vector, was previously shown to exhibit potent antiproliferative effects in vitro and to delay the onset of tumors in vivo. In this study, we performed a structure–activity relationship analysis to evaluate the significance of the inhibitor and vector moieties of JMV4463. By modifying both statine residues of pepstatin we found that the antiproliferative activity is correlated with CathD inhibition, supporting a major role of the catalytic activity of intracellular CathD in cancer cell proliferation. Replacing the vector composed of four AMPA units with other vectors was found to abolish cytotoxicity, although all of the conjugates enabled pepstatin transport into cells. In addition, the AMPA4 vector must be localized at the C terminus of the bioconjugate. The unexpected importance of the vector structure and position for cytotoxic action suggests that AMPA4 enables pepstatin to inhibit the proteolysis of critical CathD substrates involved in cell proliferation via a unique mechanism of action.
Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy‐related leukemia
Authors: Churpek Jane E. , Marquez Rafael , Neistadt Barbara , Claussen Kimberly , Lee Ming K. , Churpek Matthew M. , Huo Dezheng , Weiner Howard , Bannerjee Mekhala , Godley Lucy A. , Le Beau Michelle M. , Pritchard Colin C. , Walsh Tom , King Mary‐Claire , Olopade Olufunmilayo I. , Larson Richard A. 
Published: December 2015

BACKGROUNDRisk factors for the development of therapy‐related leukemia (TRL), an often lethal late complication of cytotoxic therapy, remain poorly understood and may differ for survivors of different malignancies. Survivors of breast cancer (BC) now account for the majority of TRL cases, making the study of TRL risk factors in this population a priority.METHODSSubjects with TRL after cytotoxic therapy for a primary BC were identified from the TRL registry at The University of Chicago. Those with an available germline DNA sample were screened with a comprehensive gene panel covering known inherited BC susceptibility genes. Clinical and TRL characteristics of all subjects and those with identified germline mutations were described.RESULTSNineteen of 88 survivors of BC with TRL (22%) had an additional primary cancer and 40 of the 70 survivors with an available family history (57%) had a close relative with breast, ovarian, or pancreatic cancer. Of the 47 subjects with available DNA, 10 (21%) were found to carry a deleterious inherited mutation in BRCA1 (3 subjects; 6%), BRCA2 (2 subjects; 4%), TP53 (tumor protein p53) (3 subjects; 6%), CHEK2 (checkpoint kinase 2) (1 subject; 2%), and PALB2 (partner and localizer of BRCA2) (1 subject; 2%).CONCLUSIONSSurvivors of BC with TRL have personal and family histories suggestive of inherited cancer susceptibility and frequently carry germline mutations in BC susceptibility genes. The data from the current study support the role of these genes in TRL risk and suggest that long‐term follow‐up studies of women with germline mutations who are treated for BC and functional studies of the effects of heterozygous mutations in these genes on bone marrow function after cytotoxic exposures are warranted. Cancer 2016;122:304–311. © 2015 American Cancer Society.
Drug–Drug Interaction of Omeprazole With the HCV Direct‐Acting Antiviral Agents Paritaprevir/Ritonavir and Ombitasvir With and Without Dasabuvir
Authors: Polepally Akshanth R. , Dutta Sandeep , Hu Beibei , Podsadecki Thomas J. , Awni Walid M. , Menon Rajeev M. 
Published: December 2015

AbstractParitaprevir (administered with low‐dose ritonavir), ombitasvir, and dasabuvir are direct‐acting antiviral agents administered as combination regimens for the treatment of chronic hepatitis C virus infection. Drug–drug interactions between 2D (ombitasvir/paritaprevir/ritonavir) or 3D (ombitasvir/paritaprevir/ritonavir and dasabuvir) regimens and omeprazole, a CYP2C19 substrate and acid‐reducing agent, were evaluated in 24 healthy volunteers. Subjects received omeprazole (40 mg once daily) on day 1 and days 20–24 and the 2D or 3D regimen (ombitasvir/paritaprevir/ritonavir 25/150/100 mg once daily ± dasabuvir 250 mg twice daily) on days 6–24. Compared with omeprazole alone, coadministration with the 2D or 3D regimen decreased omeprazole geometric mean Cmax and AUCt values by 40% to 50%. Ombitasvir, dasabuvir, and ritonavir mean exposures showed <10% change, and paritaprevir mean exposures showed <20% change when the 2D or 3D regimen was administered with omeprazole compared with administration without omeprazole. Although no a priori dose adjustment is needed, a higher omeprazole dose should be considered if clinically indicated when coadministered with the 2D or 3D regimen. No dose adjustment is required for the 2D or 3D regimen when administered with omeprazole, other acid‐reducing agents, or CYP2C19 inhibitors.
Probing Membrane Fouling via Infrared Attenuated Total Reflection Mapping Coupled with Multivariate Curve Resolution
Authors: Chen Wei , Liu Xiao‐Yang , Huang Bao‐Cheng , Wang Long‐Fei , Yu Han‐Qing , Mizaikoff Boris 
Published: December 2015

AbstractUnderstanding membrane fouling induced by dissolved organic matter (DOM) is of primary importance for developing effective fouling control and prevention strategies. In this work, we combine multivariate curve resolution–alternating least squares analysis with infrared attenuated total reflection mapping to explore the fouling process of microfiltration and ultrafiltration membranes caused by two typical DOMs, humic acid (HA) and bovine serum albumin (BSA). The spectral contributions of different foulants and the membrane substrate were successfully discriminated, thereby enabling the diagnosis of fouling origins. Membrane fouling caused by HA is more severe than that by BSA. Three periods, the initial adsorption stage, the equilibrium stage, and the accumulation stage, were observed for the HA‐induced fouling process. The integrated approach presented herein elegantly demonstrates the spatial and temporal characterization of membrane fouling processes, along with relative concentrations of the involved species, and suggests a promising perspective for understanding the interaction mechanisms between foulant species and membranes at the molecular level.
Identifying links between Fluvial Geomorphic Response Units (FGRUs) and fish species in the Assiniboine River, Manitoba
Authors: Carr Meghan K. , Watkinson Douglas A. , Lindenschmidt Karl‐Erich 
Published: December 2015

AbstractThe Assiniboine River, located in east central Saskatchewan and southwestern Manitoba, provides recreational opportunities, irrigation, and industrial and municipal water resources to Manitoba residents while supporting a diverse fish fauna. Improving our understanding of patterns in the spatial distribution of different fish species in relation to physical habitat features can aid management of this important water resource. The Fluvial Geomorphic Response Unit (FGRU) method is a geospatial modelling technique that allows the classification of large‐scale river reaches that exhibit similar geomorphic structure and provide a link between the hydrological regime and physical riverine habitats. Historical electrofishing data provide catch per unit effort data for various fish species and allow an investigation of fish distribution among different FGRUs. This study has identified significant differences (Kruskal–Wallis test,p < 0·05) in the catch per unit effort between three FGRUs for ten fish species in the Assiniboine River. These findings have the potential to increase our understanding of habitat complexity, availability, and connectivity in prairie rivers, a valuable tool for resource managers. This model can contribute to the development of sampling programmes by allowing efficienta priorisite selection, ensuring sampling of diverse unit types and thus a greater representation of the range of physical habitats present within a river system. Copyright © 2015 John Wiley & Sons, Ltd.
Enhanced Photocatalytic Performance in Ag+‐Induced BiVO4/β‐Bi2O3Heterojunctions
Authors: Shan Lianwei , Liu Yuteng , Ma Chengguo , Dong Limin , Liu Lizhu , Wu Ze 
Published: December 2015

AbstractBiVO4/β‐Bi2O3photocatalysts have been fabricated by a facile Ag doping route. The method involves the substitution of the lattice Bi3+ions in BiVO4with dopant Ag+ions, and the supplanted Bi3+ions generate the β‐Bi2O3(tetragonal phase) under thermal treatment in air. TEM observations and XRD results confirm that BiVO4and β‐Bi2O3coexist in the Ag‐doped BiVO4. The diffuse‐reflectance spectroscopy (DRS) results demonstrate that all of the BiVO4/β‐Bi2O3photocatalysts show enhanced absorption in the visible region betweenλ= 550 and 650 nm, and the absorption intensity increases as the Ag content increases. The experimental results reveal that these BiVO4/β‐Bi2O3nanostructures exhibit much higher visible‐light photocatalytic activities than that of BiVO4for the degradation of the model dye Rhodamine B (RhB) under visible‐light irradiation. The enhanced photocatalytic efficiencies are attributed to charge transfer between BiVO4and β‐Bi2O3, which significantly promotes the separation of the photogenerated electrons and holes and, therefore, enhances the photocatalytic properties of the heterojunction. Furthermore, the doped Ag ions might play an important role in this improvement. This approach is expected to be beneficial for the design and optimization of heterojunction photocatalysts.
Recent Developments in the Chemistry of 3H‐1,2,3,4‐Triazaphos­phole Derivatives
Authors: Sklorz Julian A. W. , Müller Christian 
Published: December 2015

AbstractThis microreview describes the progress that has been made during the last few years in the synthesis, coordination chemistry, and application of donor‐functionalized 3H‐1,2,3,4‐triazaphospholes, the phosphorus analogues of the well‐known 1,2,3‐triazoles. The latter class of compounds has attracted tremendous interest in various areas of chemistry due to their facile assembly through “click” chemistry. In contrast, the phosphorus‐containing analogues have received much less attention, although their synthesis is fairly straightforward, starting from organic azides and phosphaalkynes, without the need for use of any catalyst. These fascinating low‐coordinate phosphorus heterocycles have conjugated π systems with high degrees of aromaticity and possess rather high π density at their phosphorus atoms, due to significant N–C=P ↔ N+=C–P– conjugation. It has been shown recently that [3+2] cycloaddition between functionalized organic azides and phosphaalkynes also allows the incorporation of additional donor substituents into specific positions of the phosphorus heterocycle, and both chelating and polydentate triazaphospholes are nowadays synthetically accessible. These compounds have been used to prepare the first coordination compounds based on triazaphospholes, making use of the chelate effect. The recently used strategies in this area facilitate, for the first time, synthetic access to a completely new set of triazaphospholes as well as their corresponding metal complexes, leading to a much broader scope for potential applications. As a very recent highlight, experimental and theoretical findings have established triazaphospholes as a new class of phosphorus‐containing extended π systems for optoelectronic applications, because significant fluorescence emission of 2‐pyridyl‐functionalized triazaphosphole derivatives has been observed. New developments in the areas of homogeneous catalysis and materials sciences can consequently be foreseen in the near future.
Hydrophilic Ethylene‐Glycol‐Based Ruthenium Sensitizers for Aqueous Dye‐Sensitized Solar Cells
Authors: Cisneros Robin , Beley Marc , Lapicque François , Gros Philippe C. 
Published: December 2015

AbstractThree ruthenium complexes bearing glycol chains of varied length and number have been prepared and evaluated as hydrophilic sensitizers in aqueous dye‐sensitized solar cell (DSSC) devices. The new complexes performed better than N719 in a 100 % aqueous electrolyte. The use of co‐adsorbents and particularly bis(4‐methoxyphenyl)phosphinic acid (BMPP) improved the efficiency and short‐circuit photocurrent.
Palladium Complexes Bearing Mesoionic Carbene Ligands: Applications in α‐Arylation, α‐Methylation and Suzuki–Miyaura Coupling Reactions
Authors: Maity Ramananda , Verma Amit , van der Meer Margarethe , Hohloch Stephan , Sarkar Biprajit 
Published: December 2015

AbstractComplexes of mesoionic carbene (MIC) ligands are gaining immense popularity in organometallic chemistry and homogeneous catalysis. We present here a series of palladium(II) complexes that are comprised of MIC donor ligands, and we demonstrate their applications in α‐arylation, α‐methylation, and Suzuki–Miyaura coupling reactions. All the complexes have been structurally characterized by X‐ray crystallographic analysis. These palladium(II) complexes are potent precatalysts and they deliver good to excellent yields for both α‐arylation and Suzuki–Miyaura coupling reactions. A palladium(II) complex bearing two MIC units in a trans fashion is used for chemoselective Suzuki–Miyaura coupling reaction. This complex delivers lower yields in α‐arylation reactions compared with PEPPSI‐type complexes, however, it gives an α‐methylated product when the reaction is conducted in N,N‐dimethylformamide. Mercury poisoning experiments suggest that the Suzuki–Miyaura coupling reaction likely proceeds via Pd nanoparticles. However, the α‐arylation reaction proceeds homogeneously, as shown by the negative mercury poison test. The present results thus open up new avenues for MIC ligands in catalytic α‐arylation and α‐methylation reactions.
1‐O‐alkylglycerols and fatty acids of cholesteryl esters in squid oil are fully saturated and show parallel relative abundance of chain lengths. A possible compartmented fatty alcohol cycle in squid
Authors: Galliani Guido 
Published: December 2015

Squid oil is a good source for ethyl esters enriched in DHA. As usually with marine oils, ethyl esters undergo winterization. The stearin obtained from cold filtration is a mixture of relatively high melting point mostly saturated compounds. Stearin from squid ethyl esters released a solid material upon treatment with methanol. This was characterized as a mixture of 1‐O‐alkylglycerols. Replacing methanol precipitation with chromatographic separation of stearin gave the same results, ruling out preferential precipitation. Alkyl chains of 1‐O‐alkylglycerols are C16:0 preponderantly, C14:0, C18:0, and traces of C15:0 and C17:0. No unsaturated alkyl chains were detected by GC‐MS and 13C‐NMR. However, 1‐O‐alkylglycerols were not detected in crude squid oil. They were contained in the crude oil mainly in the form of 1‐O‐alkyl‐2,3‐diacylglycerols and lesser amounts of plasmanyl‐phospholipids. The alkyl chain distribution recalls the result found in the case of acyl chains of cholesteryl esters in crude squid oil. These findings suggest that the biochemical build‐up of 1‐O‐alkylglycerols and cholesteryl esters in squid follows a common compartmented pathway, different than the metabolism of glycerides, rich in mono‐ and polyunsaturated fatty acid. A hypothesis is put forward based on the fatty alcohol cycle.Practical applications: Ethyl esters from squid crude oil are enriched by short path distillation to give ethyl esters containing high amounts of DHA. As a part of usual processes leading to omega‐3 concentrated marine oils, enriched ethyl esters undergo winterization. During this step, ethyl esters with relatively high melting point are crystallized at low temperature and removed by filtration. The usual effect of winterization is to contribute to a slight further enrichment in polyunsaturated compounds. The present work shows that winterization also contributes in removing 1‐O‐alkylglycerols, produced from 1‐O‐alkyl‐2,3‐diacylglycerols during ethanolysis of squid oil. A smaller part of 1‐O‐alkylglycerols is contained in the starting squid oil in the form of plasmanyl‐phospholipids, which are likely removed during initial degumming.A gas chromatogram of fatty acid methyl esters from squid cholesteryl esters (top) compared to a gas chromatogram of isopropylidene derivatives from squid 1‐O‐alkylglycerols (down).