bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inferring bacterial interspecific interactions from microcolony growth expansion
Authors: Miguel Trabajo Tania , Guex Isaline , Dubey Manupriyam , Sarton-Lohéac Elvire , Todorov Helena , Richard Xavier , Mazza Christian , van der Meer Jan Roelof 
Published: October 2024

Abstract
Bacterial species interactions significantly shape growth and behavior in communities, determining the emergence of community functions. Typically, these interactions are studied through bulk population measurements, overlooking the role of cell-to-cell variability and spatial context. This study uses real-time surface growth measurements of thousands of sparsely positioned microcolonies to investigate interactions and kinetic variations in monocultures and cocultures of Pseudomonas putida and P. veronii under substrate competition (succinate) or substrate independence (d-mannitol and putrescine). In monoculture, microcolonies exhibited expected substrate-dependent expansion rates, but individual colony sizes were affected by founder cell density, spatial positioning, growth rates, and lag times. In coculture, substrate competition favored P. putida, but unexpectedly, reduced the maximum growth rates of both species. In contrast, 10% of P. veronii microcolonies under competition grew larger than expected, likely due to founder cell phenotypic variation and stochastic spatial positioning. These effects were alleviated under substrate independence. A linear relationship between founder cell ratios and final colony area ratios in local neighborhoods (6.5–65 µm radius) was observed in coculture, with its slope reflecting interaction type and strength. Measured slopes in the P. putida to P. veronii biomass ratio under competition were one-third reduced compared to kinetic predictions using a cell-agent growth model, which exometabolite analysis and simulations suggested may be due to metabolite cross-feeding or inhibitory compound production. This indicates additional factors beyond inherent monoculture growth kinetics driving spatial interactions. Overall, the study demonstrates how microcolony growth experiments offer valuable insights into bacterial interactions, from local to community-level dynamics.
The Unseen Shift: How Partnership Long-term Care Insurance Influences Caregiving Among Older Adults
Authors: Zai Xianhua 
Published: October 2024

Abstract

Objectives
Although the partnership long-term care insurance (PLTC) program was designed to mitigate the low uptake of long-term care insurance (LTCI) and reduce Medicaid’s financial burden, research has predominantly focused on its direct impacts, leaving the effects on informal caregiving unexplored. This study aimed to investigate how the program alters the dynamics of family-provided care, leveraging nationally representative data to unveil the broader consequences of informal caregiving arrangements among older individuals.

Methods
Data for this study were sourced from the U.S. Health and Retirement Study (1992–2018) and linked with the timing of the PLTC program implementation across states. The analysis compared individuals exposed to the program with those who were not, employing 2-way-fixed-effects and dynamic models to assess its impact on LTCI coverage and reliance on informal caregiving.

Results
The program positively affected LTCI coverage, increasing insurance uptake among older individuals in the long run. Conversely, a significant negative effect was observed on the receipt of assistance from any helper, indicating a reduced reliance on informal care. This reduction extended specifically to family helpers and children’s assistance with activities of daily living. The analysis suggests that the program effectively reduced the necessity for informal caregiving across several domains.

Discussion
These findings highlight the program’s potential to reshape caregiving dynamics, suggesting the need for policies that balance promoting private insurance uptake with the implications for family caregiving roles. Policymakers should consider both the economic benefits and the social shifts induced by such programs in the long-term care landscape.
Survey on competition law developments in the sports sector—January 2022 to June 2024
Authors: Ianc Sînziana , Hömann Aurélien 
Published: October 2024

Abstract
The survey offers a comprehensive overview of the EU competition law and policy developments between January 2022 and June 2024, covering competition authorities and courts at both EU and national level.
Once considered exempt of the application of competition law due to its ‘specificity’, the sports industry and in particular the rules and sanctions imposed by sports governing bodies now face enhanced scrutiny under Articles 101 and 102 TFEU and the scope of the initial exemption is getting gradually more limited. The Court of Justice’s established Meca-Medina doctrine is being re-shaped, with questions of interpretation and the scope of application challenging competition authorities and courts. Competition law enforcement is strongly driven by private complaints and litigation and the case law of the Court of Justice of the EU. Requests for interim measures are growing in importance. Moreover, national competition authorities also keep themselves busy with sports matters, ranging from investment and reclassification rules to no-poach agreements, with the German authority at the forefront.
Super-resolution microscopy unveils the nanoscale organization and self-limiting clustering of CD47 in human erythrocytes
Authors: Yang Jianyu , Xing Fulin , Hu Fen , Hou Mengdi , Dong Hao , Cheng Jiayu , Li Wan , Yan Rui , Xu Jingjun , Xu Ke , Pan Leiting 
Published: October 2024

Abstract
The transmembrane protein CD47, an innate immune checkpoint protein, plays a pivotal role in preventing healthy erythrocytes from immune clearance. Our study utilized stochastic optical-reconstruction microscopy (STORM) and single-molecule analysis to investigate the distribution of CD47 on the human erythrocyte membrane. Contrary to previous findings in mouse erythrocytes, we discovered that CD47 exists in randomly distributed monomers rather than in clusters across the human erythrocyte membrane. Using 2nd antibody-induced crosslinking, we found that CD47 aggregates into stable clusters within minutes. By comparing these STORM results with those of the fully mobile protein CD59 and the cytoskeleton-bound membrane protein glycophorin C under similar conditions, as well as devising two-color STORM co-labeling and co-clustering experiments, we further quantitatively revealed an intermediate, self-limiting clustering behavior of CD47, elucidating its fractional (∼14%) attachment to the cytoskeleton. Moreover, we report reductions in both the amount of CD47 and its clustering capability in aged erythrocytes, providing new insight into erythrocyte senescence. Together, the combination of STORM and 2nd antibody-based crosslinking unveils the unique self-limiting clustering behavior of CD47 due to its fractional cytoskeleton attachment.
Outcomes Associated with Healthcare-Associated Respiratory Syncytial Virus in Children’s Hospitals
Authors: Saiman Lisa , Coffin Susan E , Kociolek Larry K , Zerr Danielle M , Milstone Aaron M , Aldrich Margaret L , Vargas Celibell Y , Zalot Morgan A , Reyna Megan E , Adler Amanda , Koontz Danielle , Egbert Emily R , Alrikaby Jassour , Alba Luis , Gollerkeri Sonia , Ruggieri Madelyn , Finelli Lyn , Choi Yoonyoung 
Published: October 2024

Abstract
To determine if healthcare-associated (HA)-respiratory syncytial virus (RSV) is associated with worse outcomes, this multicenter cohort study studied 26 children with HA-RSV and 78 matched non-HA-RSV patients of whom 58% and 55%, respectively, had ≥2 comorbidities. Overall, 39% of HA-RSV versus 18% of non-HA-RSV patients required respiratory support escalation (adjusted odds ratio (aOR) 5.1, CI95 1.4, 19.1).
Duration, Cost, and Escalation of Care Events for Physical Therapy Management of Low Back Pain in Service Members With Limb Loss
Authors: Gunterstockman Brittney M , Hendershot Brad D , Kakyomya Joseph , Patterson Charity G , Dearth Christopher L , Farrokhi Shawn 
Published: October 2024

ABSTRACT

Introduction
Physical therapy (PT) is recommended as a primary treatment for low back pain (LBP), a common and impactful musculoskeletal condition after limb loss. The purpose of this brief report is to report the duration and cost of PT care, and subsequent escalation of care events, for LBP in service members with and without limb loss.

Materials and Methods
This was a retrospective cohort, descriptive study. Service members with and without limb loss (matched) who received PT for LBP at a military treatment facility from 2015 to 2017 were included. Duration of PT care, number of PT visits, and escalation of care events 1 year after PT were extracted from medical records. Escalation of care events was identified as epidural steroid injections, referrals to specialists (e.g., orthopedists, spine surgeons, and pain management), and LBP-related hospitalizations.
LBP-related PT encounters were queried; duration of care, number of visits, and cost of care were quantified. Escalation of care events, including opioid prescription, epidural steroid injections, specialty referrals, and hospitalizations, were identified up to 1 year after PT care.

Results
The average course of PT care for LBP was 12.9 more visits, 48.7 days longer, and $764.50 more expensive in service members with limb loss (n = 16) vs. those without limb loss (n = 48). Higher rates of opioid prescriptions and specialty referrals were observed in service members with limb loss.

Conclusions
This study suggests that service members with limb loss and LBP received higher quantities and longer durations of PT than those without limb loss, yielding a nearly 4 times higher cost of PT.
Mapping the Fetal Alcohol Spectrum Disorder Continuum of Care Across the Military Health System
Authors: Rivera Ilse , Lee Elizabeth H , Solomon Zoe , Koehlmoos Tracey P 
Published: October 2024

ABSTRACT

Introduction
Although a leading cause of developmental disability in the United States, many individuals with fetal alcohol spectrum disorders (FASDs) do not receive a timely diagnosis, are misdiagnosed, or are never diagnosed. Prevention, diagnosis, and clinical management of FASD have not been previously studied in the U.S. Military Health System (MHS), where nearly 1 million of the nation’s children receive health care. To address this gap, we undertook an environmental scan of the clinical guidelines, services, programs, educational resources, and policies within the MHS pertaining to alcohol use (AU), AU disorder (AUD), prenatal alcohol exposure, and FASD.

Materials and Methods
From March to June 2023, we undertook an environmental scan of MHS clinical guidelines, services, programs, educational resources, and policies that address AU, AUD, prenatal alcohol exposure, and FASD.

Results
We identified multiple resources that attended to AU and AUD before and during pregnancy in the MHS. However, despite numerous resources for other neurodevelopmental disorders, we did not find any MHS-specific resources that address diagnosis and management of FASD.

Conclusions
Findings suggest opportunities to raise awareness, educate providers, and improve guidelines, policies, and practices in the MHS.
The ACCEL2 project: Simulating Lyman-α forest in large-volume hydrodynamical simulations
Authors: Chabanier Solène , Ravoux Corentin , Latrille Lucas , Sexton Jean , Armengaud Éric , Bautista Julian , Dumerchat Tyann , Lukić Zarija 
Published: October 2024

Abstract
Cosmological information is usually extracted from the Lyman-α (Lyα) forest correlations using only either large-scale information interpreted through linear theory or using small-scale information interpreted by means of expensive hydrodynamical simulations. A complete cosmological interpretation of the 3D correlations at all measurable scales is challenged by the need of more realistic models including the complex growth of non-linear small scales that can only be studied within large hydrodynamical simulations. Past work were often limited by the trade off between the simulated cosmological volume and the resolution of the low-density intergalactic medium from which the Lyαsignal originates. We conduct a suite of hydrodynamical simulations of the intergalactic medium, including one of the largest Lyαsimulations ever performed in terms of volume (640  h−1 Mpc), alongside simulations in smaller volumes with resolutions up to 25  h−1 kpc, which will be further improved to show resolution convergence in future studies. We compare the 3D Lyα power spectra (P3D, α) predicted by those simulations to different non-linear models. The inferred Lyαbias and redshift space distortion (RSD) parameters, bα and βα are in remarkable agreement with those measured in SDSS and DESI data. We find that, contrary to intuition, the convergence of large-scale modes of the P3D, α, which determines βα, is primarily influenced by the resolution of the simulation box through mode coupling, rather than the box size itself. Finally, we study the BAO signal encoded in P3D, α. For the first time with a hydrodynamical simulation, we clearly detect the BAO signal, however we only marginally detect its damping, associated with the non-linear growth of the structures.
Optical and X-ray studies of the Be/X-ray binary IGR J06074+2205
Authors: Chhotaray Birendra , Naik Sachindra , Jaisawal Gaurava K , Ahuja Goldy 
Published: October 2024

ABSTRACT
We present the results obtained from X-ray and optical analysis of the Be/X-ray binary IGR J06074+2205, focusing on before, during, and after the X-ray outbursts in 2023 October and December. The properties of the neutron star in the binary are investigated using NICER and NuSTAR observations during the X-ray outbursts. The pulse profiles across a broad energy range, are found to be strongly dependent on luminosity and energy, revealing the complex nature of the emitting region. An absorbed power law can describe each NICER spectrum in the 1–7 keV band. The 3–79 keV NuSTAR spectrum can be well described by a negative and positive power law with an exponential cut-off model. Utilizing the MAXI/GSC long-term light curve, we estimate the probable orbital period to be 80 or 80/n (n = 2, 3, 4) d. We investigate the evolution of the circumstellar disc around the Be star by using optical spectroscopic observations of the system between 2022 and 2024. We observe variable H $\alpha$ and Fe ii emission lines with an increase in equivalent width, indicating the presence of a dynamic circumstellar disc. A distinct variation in the V/R value for H $\alpha$ and Fe ii lines is also observed. The appearance of additional emission lines, such as He i (5875.72 Å), He i (6678 Å), and He i (7065 Å), during the post-outburst observation in 2024 February suggests the growing of a larger or denser circumstellar disc. The disc continues to grow without any noticeable mass-loss, even during the 2023 X-ray outbursts, which may lead to a future giant X-ray outburst.
Piloting a Collaborative Psychosocial Intervention for Hospitalized Infants and Their Caregivers
Authors: Kim Dana , Perrotti Morgan , Keller Briana , Boles Jessika 
Published: October 2024

Abstract
The diagnosis of cancer or cardiac abnormalities in infants is often associated with prolonged hospitalization, which can negatively impact caregiver-child bonding due to separation, medical stressors, and changes in the caregiving role. The purpose of this study was to pilot an interdisciplinary psychosocial intervention including songwriting, an expressive journal and activity book, and a bonding assessment. Interventions were facilitated by a board-certified music therapist and Certified Child Life Specialist. A total of 15 families completed the pretest, four intervention sessions, and post intervention test. Quantitative data suggest increased caregiver–child bonding and increased caregiver confidence. Caregivers reported high levels of satisfaction with the intervention in qualitative responses. In summary, results from this pilot study lay the groundwork for a future larger-scale evaluation.
Design and conduct of theranostic trials in neuro-oncology: Challenges and opportunities
Authors: Wen Patrick Y , Preusser Matthias , Albert Nathalie L 
Published: October 2024

Abstract
Theranostics is a new treatment modality integrating molecular imaging with targeted radionuclide therapy. Theranostic agents have received regulatory approval for some systemic cancers and have therapeutic potential in neuro-oncology. As clinical trials are developed to evaluate the efficacy of theranostic agents in brain tumors, specific considerations will have to be considered, taking into account lessons learned from previous studies examining other treatment modalities in neuro-oncology. These include the need for molecular imaging or surgical window-of-opportunity studies to confirm adequate passage across the blood-brain barrier, optimize eligibility criteria, and selection of the most appropriate response criteria and endpoints to address issues such as pseudoprogression. This review will discuss some of the issues that should be considered when designing clinical trials for theranostic agents.
Betel Quid Use and Tuberculosis Transmission: A Neglected Focus Area for Tuberculosis Control in Low- and Middle-Income Countries
Authors: Manghani Priyanka , Prasad Narayana , Khatri Nishtha , Paulino-Ramirez Robert , Gokhale Shishir , Islam K M Monirul , Majumdar Piyusha , Hoang Tran , Denny Hanifa 
Published: October 2024

Abstract
Habitual betel quid consumption and spitting contribute to tuberculosis (TB) transmission due to direct exposure to pathogens, immunosuppression, and social contact. Despite betel quid being classified as a group 1 human carcinogen and a high prevalence of betel quid consumption in patients with TB, there exists a knowledge gap in the relationship between quid use and TB, which presents as a neglected opportunity to address the global burden of TB in low- and middle-income countries. Understanding such a knowledge gap is crucial when taking measures at various levels, including research prioritization, behavior change communication, and legislation to address the availability and access of quid products, coupled with community-based interventional strategies. This article thus presents empirical evidence on quid use and its effects on TB spread and identifies feasible, applicable changes required at various levels to curtail the spread of TB among betel quid users.
The Psychosis MRI Shared Data Resource (Psy-ShareD)
Authors: Allen Paul , Zurita Mariana , Easmin Rubaida , Bucci Sara , Kempton Matthew J , Rogers Jack , Mehta Urvakhsh M , McGuire Philip K , Lawrie Stephen M , Whalley Heather , Gadelha Ary , Murray Graham K , Garrison Jane R , Frangou Sophia , Upthegrove Rachel , Evans Simon L , Kumari Veena ,   the Psy-ShareD Partnership
Published: October 2024

AbstractA key line of research in the field of schizophrenia and other psychotic disorders has been to investigate neuroanatomical markers, relative to healthy control groups. In recent decades, a large number of structural Magnetic Resonance Imaging (MRI) studies have been funded and undertaken, but their small sample sizes and heterogenous methods have led to inconsistencies across findings. To tackle this, efforts have been made to combine datasets across studies and sites. While notable recent multi-centre initiatives and both meta- and mega-analytical studies have progressed the field, efforts have generally been restricted to MRI scans in one or two illness stages which are not always representative of the diversity of patients who experience psychosis. Furthermore, access to these datasets is usually restricted to consortia members, often from high income countries. The Psychosis MRI Shared Data Resource (Psy-ShareD) is a new open access structural MRI data sharing partnership that will host pre-existing structural T1-weighted MRI data collected across multiple sites worldwide, including the Global South. MRI T1 data included in Psy-ShareD will be available in image and feature level formats, having been harmonised using state-of-the-art approaches. All T1 data will be linked to demographic and illness-related (diagnosis, symptoms, medication status) measures and in a number of datasets IQ and cognitive data, and medication history will also be available. Psy-ShareD will be free to access for all researchers. Comprehensive data catalogues, support and training resources will be available to facilitate use by early career researchers and build capacity in the field. We are actively seeking new collaborators to contribute further T1 data. Collaborators will benefit in terms of authorships, as all publications arising from Psy-ShareD will include data contributors as authors.
Classifying Alzheimer’s Disease and Dementia Patients Using Non-invasive EEG Biomarkers
Authors: Hasan Wali , Khan Sheraz , Sohrabpour Abbas 
Published: October 2024

AbstractResearchers are currently exploring methods to detect early-stage Alzheimer’s Disease (AD) and other forms of dementia such as frontotemporal dementia (FTD), especially through non-invasive biomarkers, i.e., measurements that reflect biological processes. This paper utilizes a dataset of electroencephalogram (EEG) recordings, a noninvasive biomarker, to distinguish individuals with Alzheimer’s or frontotemporal dementia from healthy control subjects. This paper explores the usage of machine learning methods to more accurately predict the cognitive status of patients from these non-invasive EEG Biomarkers. We found that AD patients could be easily separated from healthy controls based on their EEG features using simple linear classifiers with an accuracy of 77% and the AD, FTD, and healthy controls with an accuracy of around 57% (randomly selecting the right class is about one third or 33% in the 3-way classification).