bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal and neonatal echocardiographic analysis of biomechanical alterations for the systemic right ventricle heart
Authors: Meyers Brett A. , Bhattacharya Sayantan , Brindise Melissa C. , Loke Yue-Hin , Payne R. Mark , Vlachos Pavlos P. 
Published: September 2024

Background
The perinatal transition’s impact on systemic right ventricle (SRV) cardiac hemodynamics is not fully understood. Standard clinical image analysis tools fall short of capturing comprehensive diastolic and systolic measures of these hemodynamics.

Objectives
Compare standard and novel hemodynamic echocardiogram (echo) parameters to quantify perinatal changes in SRV and healthy controls.

Methods
We performed a retrospective study of 10 SRV patients with echocardiograms at 33-weeks gestation and at day of birth and 12 age-matched controls. We used in-house developed analysis algorithms to quantify ventricular biomechanics from four-chamber B-mode and color Doppler scans. Cardiac morphology, hemodynamics, tissue motion, deformation, and flow parameters were measured.

Results
Tissue motion, deformation, and index measurements did not reliably capture biomechanical changes. Stroke volume and cardiac output were nearly twice as large for the SRV compared to the control RV and left ventricle (LV) due to RV enlargement. The enlarged RV exhibited disordered flow with higher energy loss (EL) compared to prenatal control LV and postnatal control RV and LV. Furthermore, the enlarged RV demonstrated elevated vortex strength (VS) and kinetic energy (KE) compared to both the control RV and LV, prenatally and postnatally. The SRV showed reduced relaxation with increased early filling velocity (E) compared prenatally to the LV and postnatally to the control RV and LV. Furthermore, increased recovery pressure (ΔP) was observed between the SRV and control RV and LV, prenatally and postnatally.

Conclusions
The novel hydrodynamic parameters more reliably capture the SRV alterations than traditional parameters.
Suspected intracranial hypertension in COVID-19 patients with severe respiratory failure
Authors: Carbonara Marco , Ferrari Erica , Birg Tatiana , Punzi Veronica , Bichi Francesca , Lazzari Beatrice , Palmaverdi Valentina , Bottino Nicola , Ortolano Fabrizio , Zoerle Tommaso , Conte Giorgio , Stocchetti Nino , Zanier Elisa R. ,   The UOC Terapia Intensiva Presidio Temporaneo Fiera Milano investigators group
Published: September 2024

Background
COVID-19 patients may exhibit neurological symptoms due to direct viral damage, systemic inflammatory syndrome, or treatment side effects. Mechanical ventilation in patients with severe respiratory failure often requires sedation and neuromuscular blockade, hindering thorough clinical examinations. This study aimed to investigate neurological involvement through clinical and noninvasive techniques and to detect signs of intracranial hypertension in these patients.

Method
We conducted a prospective observational study on mechanically ventilated COVID-19 adult patients admitted to our ICU, following standard of care protocols for ventilation and permissive hypercapnia. Data were collected at three time points: admission day (T1), day seven (T7), and day fourteen (T14). At each time point, patients underwent multimodal noninvasive neurological monitoring, including clinical examination, pupillary reactivity, transcranial color doppler of the middle cerebral artery (MCA), and optic nerve sheath diameter (ONSD) assessed via ultrasound (US). Head computer tomography (CT) was performed at T1 and T14. A limited subset of patients had a follow-up examination six months after ICU discharge.

Results
Seventy-nine patients were recruited; most were under deep sedation and neuromuscular blockade at T1. Pupillary size, symmetry, and reactivity were normal, as was the MCA mean velocity. However, ONSD, assessed by both US and CT, appeared enlarged, suggesting raised intracranial pressure (ICP). In a subgroup of 12 patients, increased minute ventilation was associated with a significant decrease in US-ONSD, corresponding to a drop in paCO2. At follow-up, twelve patients showed no long-term neurological sequelae, and US-ONSD was decreased in all of them.

Discussion and conclusions
In this cohort, enlarged ONSD was detected during non-invasive neurological monitoring, suggesting a raised ICP, with hypercapnia playing a prominent role. Further studies are needed to explore ONSD behavior in other samples of mechanically ventilated, hypercapnic patients.
Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model
Authors: Lu Yuanqing , Mohammad Naweed S. , Lee Jungnam , Aranyos Alek M. , Serban Karina A. , Brantly Mark L. 
Published: September 2024

Background
Alpha-1 antitrypsin deficiency (AATD) is an inherited disease, the common variant caused by a Pi*Z mutation in the SERPINA1 gene. Pi*Z AAT increases the risk of pulmonary emphysema and liver disease. Berberine (BBR) is a nature dietary supplement and herbal remedy. Emerging evidence revealed that BBR has remarkable liver-protective properties against various liver diseases. In the present study, we investigated the therapeutic effects and toxicities of BBR in Pi*Z hepatocytes and Pi*Z transgenic mice.

Methods
Huh7.5 and Huh7.5Z (which carries the Pi*Z mutation) cells were treated with different concentrations of BBR for 48 hours. MTT was performed for cell viability assay. Intracellular AAT levels were evaluated by western blot. In vivo studies were carried out in wild type, native phenotype AAT (Pi*M), and Pi*Z AAT transgenic mice. Mice were treated with 50 mg/kg/day of BBR or solvent only by oral administration for 30 days. Western blot and liver histopathological examinations were performed to evaluate therapeutic benefits and liver toxicity of BBR.

Results
BBR reduced intracellular AAT levels in Huh7.5Z cells, meanwhile, no Pi*Z-specific toxicity was observed. However, BBR did not reduce liver AAT load but significantly potentiated liver inflammation and fibrosis accompanying the activation of unfolded protein response and mTOR in Pi*Z mice, but not in wild type and Pi*M mice.

Conclusions
BBR exacerbated liver inflammation and fibrosis specifically in Pi*Z mice. This adverse effect may be associated with the activation of unfolded protein response and mTOR. This study implicates that BBR should be avoided by AATD patients.
Adherence to cardiovascular medications and risk of cardiovascular disease in breast cancer patients: A causal inference approach in the Pathways Heart Study
Authors: Kwan Marilyn L. , Pimentel Noel , Izano Monika , Iribarren Carlos , Rana Jamal S. , Nguyen-Huynh Mai , Cheng Richard , Laurent Cecile A. , Lee Valerie S. , Roh Janise M. , Rillamas-Sun Eileen , Hershman Dawn L. , Kushi Lawrence H. , Greenlee Heather , Neugebauer Romain 
Published: September 2024

Purpose
Women with breast cancer (BC) are at high risk of developing cardiovascular disease (CVD). We examined adherence to CVD medications and their association with major CVD events over 14 years of follow-up in the Pathways Heart Study, a prospective study of 4,776 stage I-III BC patients diagnosed from 2005–2013.

Methods
Eligibility included being alive 6 months post-BC diagnosis, with dyslipidemia, hypertension, or diabetes at diagnosis along with ≥1 prior outpatient order or dispensing for a statin, anti-hypertensive, or diabetes medication, respectively, in the 30 months prior. Medication adherence was measured from pharmacy data to calculate cumulative average adherence (CAA). Incident heart failure (HF), ischemic heart disease (IHD), and stroke were determined via validated diagnosis and procedure codes. Working marginal structural models (MSM) fitted with inverse probability weighting evaluated the effect of adherence regimens on the hazards for each CVD event, while controlling for baseline and time-varying confounders. MSM parameterizations included: 1) CAA<100% versus CAA = 100% (ref), 2) CAA<80% versus CAA≥80% (ref) and 3) CAA<80% versus 80%≤CAA<100% versus CAA = 100%.

Results
Poor statin adherence (CAA<80%) was associated with higher risk of composite CVD (HR = 2.54; 95% CI: 1.09, 5.94) versus CAA≥80%. Poor statin adherence was also associated with a higher risk of stroke (HR = 8.13; 95% CI: 2.03, 32.51) but not risk of IHD and HF. Further, compared with perfect adherence (CAA = 100%), good adherence (80%≤CAA<100%) was associated with lower risk (HR = 0.35; 95% CI: 0.13, 0.92) while poor adherence (CAA<80%) was associated with higher risk of composite CVD (HR = 2.45; 95% CI: 1.05, 5.70). Levels of adherence to anti-hypertensives and diabetes medications had mixed or null associations with risk of CVD.

Conclusions
Maintaining good adherence (≥80%) to statins after BC treatment is beneficial for cardiovascular health in patients with dyslipidemia. Future studies should determine factors associated with lower adherence to statins and ways to improve adherence.
Respiratory and physical health consequences in older adults in a high-risk volcanic area: Comparison of two rural villages
Authors: Benavides-Cordoba Vicente , Suarez Andres , Guerrero-Jaramillo Diana , Silva-Medina Melissa , Betancourt-Peña Jhonatan , Palacios-Gómez Mauricio 
Published: September 2024

Introduction
Volcanism is an important natural producer of pollution that impacts health and the quality of the environment. Lung changes caused by exposure to volcanoes have been previously studied. However, limited information exists regarding the effects of prolonged exposure to volcanic compounds. So, this study aimed to analyze the pulmonary effects and stress tolerance in older adults for chronic exposure to the volcanic ashes of the Galeras volcano.

Methods
A descriptive cross-sectional study of association included rural inhabitants aged over 60 years from Genoy, a village located in a high volcanic hazard zone of Galeras volcano, 2603 meters above sea level. Those in this group, called exposed, were contrasted with a sample of El Encano inhabitants with similar socioeconomic and cultural characteristics. Both villages belong to the rural area of San Juan de Pasto in Colombia.

Results
It was found that of 31 exposed participants, 18 had obstructive alteration, and in the control group, it was found that of 31 subjects, 6 presented this alteration. The difference between the two groups was significant (p<0.001). A similar situation occurred with distal airway obstruction assessed with the forced expiratory flow of 25–75%. No significant differences were found in restrictive alteration between the exposed and unexposed groups.

Conclusion
Chronic exposure to volcanic compounds has generated obstructive changes in the population, and these changes were greater in number and severity than those in the control group of unexposed people.
MUHAMMAD SHAÎRÙR’S AND ABÙ ZAYD’S Interpretations of Qur’anic Verses on Inheritance
Authors: Syamsuddin Sahiron 
Published: September 2024

Kajian dalam artikel ini merupakan kajian komparatif terhadap penafsiran penggalan Q.S. 4:11, yakni: “ ... bagi seorang anak laki-laki semisal bagian dua anak perempuan ...”. Yang dijadikan fokus pembahasan adalah penafsiran dua pemikir muslim kontemporer, MuÎammad ShaÎrÙr dan AbÙ Zayd, dengan pertimbangan bahwa keduanya memiliki kecenderungan interpretatif yang berbeda. ShaÎrÙr lebih cenderung menafsirkan Al-Qur’an secara subyektivis, sedangkan AbÙ Zayd lebih menekankan pada analisis historis yang kemudian memperhatikan rekontekstualisasi nilai ayat yang ditafsirkan. Artikel ini menunjukkan bahwa dua pemikir tersebut berbeda dalam menafsirkan penggalan ayat tersebut. Selain itu, penulis artikel menunjukkan juga bahwa ShaÎrÙr memiliki dua model penafsiran: (1) dalam kitab pertamanya, al-Kitab wa al-Qur’an, yang lebih menekankah teori batas (al-Îadd al-adnÁ dan al-Îadd al-a‘lÁ), dan (2) dalam kitab keempatnya, NaÎwa UsÙl JadÐdah, yang mengaplikasikan teori matematika modern. Dalam pandangan penulis artikel, penafsiran AbÙ Zayd memiliki ketersinggungan, meski tidak equivalent, dengan penafsiran ShaÎrÙr dalam kitab pertamanya.
KELUARGA BERENCANA DALAM RANGKA MEWUJUDKAN KELUARGA SAKINAH DI MUNGKID, MAGELANG, JAWA TENGAH
Authors: Setyaningsih Yunika Isma , Ibrahim Malik 
Published: September 2024

In 1970 the family planning program (KB) became popular, then disseminated to various regions in Indonesia. When the demand is still relatively small due to stumble to the problem of whether its allowed or not allowed to run this program by the law of Islam. In addition, Lack of public awareness of KB regarding the usefulness or importance of family planning. This paper presents an overview of the implementation of KB from Islamic law perspective in the village of Ngrajek in order to consummate the harmonious family. Basically, the determining or primary factor of the realization of the harmonious family is the awareness and responsibility of husband and wife in their functions and roles, as well as the rights and obligations of conjugal supported by the family economy. Thus, the use of KB contraceptives is only a secondary factor. Therefore, harmonious family phasing criteria set by the Ministry of Religion, highlights from the viewpoint of religious life and the family economy. Implementation of KB on the family in accordance with Islamic law, because their motivation in family planning(KB) Program is for the welfare of the family and to adjust the spacing of birth, and do not cause madlarat for each family. [Pada tahun 1970 Keluarga Berencana mulai populer, kemudian disosialisasikan ke berbagai daerah di Indonesia. Saat itu peminatnya masih relatif sedikit karena terbentur dengan masalah boleh atau tidaknya ber-KB menurut agama. Selain itu, kesadaran masyarakat juga masih kurang mengenai kegunaan atau pentingnya ber-KB. Tulisan ini memaparkan pandangan Hukum Islam mengenai pelaksanaan KB di Desa Ngrajek dalam rangka mewujudkan keluarga sakinah. Pada dasarnya, penentu atau faktor primer terwujudnya keluarga sakinah adalah kesadaran dan tanggung jawab suami isteri dalam menjalankan peran dan fungsinya, serta menjalankan hak dan kewajiban suami isteri yang didukung oleh perekonomian keluarga. Jadi, memakai alat kontrasepsi KB hanya faktor sekunder saja. Sebab, kriteria pentahapan keluarga sakinah yang ditetapkan oleh Kementerian Agama banyak menyoroti dari sudut pandang kehidupan beragama dan perekonomian keluarga. Pelaksanaan KB pada keluarga telah sesuai dengan syariat Islam, karena motivasi mereka dalam ber-KB adalah untuk mewujudkan kesejahteraan keluarga dan untuk mengatur jarak kelahiran, serta tidak menimbulkan madlarat bagi masing-masing keluarganya.]
PERALIHAN AGAMA SEBELUM PEMBAGIAN WARISAN MENURUT IBNU TAIMIYAH
Authors: Hadi Samsul 
Published: September 2024

The Islamic inheritance law established that the inheritance is devided to heirs (al-wâris) after the owner’s (almuwarris) died. This division should be done immediately after the obligations associated with obtaining a death and property were paid. In the reality, inheritance is often not divided immediately, so thet giving rise to other legal consequences for heirs. For example is the change of religion of heirs. In the Islamic heritance law, religious diference is the barrier to receiving inheritance. Ibn Taimiyya argued, that the religion of heirs is the religion when the inheritance divided, and not when the owner’s (al-muwarris) died.[Hukum waris Islam menetapkan bahwa harta warisan dibagikan setelah pewaris meninggal dunia dan segera mungkin dibagi kepada ahli waris (al-wâris). Namun dalam realitas kehidupan umat Islam sering terjadi harta warisan tidak dibagi dengan segera sehingga dapat menimbulkan akibat hukum lain bagiahli waris. Sebagai contoh terjadinya perubahan agama ahli waris sebelum terjadinya pembagian waris. Dalam hukum waris Islam perbedaan agama antara pewaris dengan ahli waris merupakan penghalang terjadinya kewarisan. Ibnu Taimiyah berpendapat, bahwa agama yang menjadi pegangan dalam pembagianwarisan adalah agama yang dianut ketika pembagian warisan, dan bukan ketika pewaris (al-muwarris) meninggal dunia.]
ISTERI SEBAGAI KEPALA RUMAH TANGGA: Perspektif Ulama Salaf dan Kiai-Kiai Pon-Pes Krapyak Yayasan Ali Maksum
Authors: Maylissabet Maylissabet 
Published: September 2024

Most of patriarch is a husband, but shouldn’t wife as patriarch deemed to be a strange of the public. Most of Ulama’ antecedently had a notion that a patriarch it is a husband responsibility, because a woman reputed weak in a leadership. Husband and wife uninitiated of a reality marriage, often appearing jealousy of each right and obligation, and end all with legal separation. From this phenomenon, will be research about wife as patriarch from the side of ulama-ulama in Ali Maksum Institute of Krapyak Muslim Boarding School.[Kepala rumah tangga dalam keluarga mayoritas dipegang oleh suami, akan tetapi tidak seharusnya isteri sebagai kepala rumah tangga dianggap sebagai hal yang tabu bagi masyarakat. Mayoritas ulama salaf juga berpendapat bahwa kepemimpinan dalam rumah tangga merupakan hak suami, karena perempuan dinilai lemah dalam bidang kepemimpinan. Suami dan isteri yang kurangmemahami hakikat dari sebuah perkawinan, sering muncul kecemburuan hak dan kewajiban masingmasing dan berakhir dengan sebuah perceraian. Dari fenomena ini, akan dibahas mengenai isteri sebagai kepala rumah tangga dari sisi ulama masa kini khusunya Kiai-Kiai Pondok Pesantren Krapyak Yaysan Ali Maksum di Yogyakarta.]
HUKUM KELUARGA ISLAM DI NEGARA BERPENDUDUK MINORITAS MUSLIM (Studi Hukum Keluarga di Inggris)
Authors: Abadi Khafid 
Published: September 2024

Among Muslims, there is no denying the existence of Islamic law with the character of universality existence. This is supported by the passages of the Qur’an al-Anbiya> ‘ (21) 107. Universality enforceability of Islamic law necessitates submission of all followers of Islam on the teachings of Islam, wherever and whenever they are in, and also necessitates the existence of universal values embodied in the laws of branches that may differ from one place and other places. That’s why Muslims in Islamic countries and countries relative Muslim majority found no obstacles in relation to the application of Islamic law in their daily lives. Reality in the Islamic law is different if grown among the Muslims who are a minority in a secular country, namely the state with the government system separating religion as a matter private. In this paper will be discussed how a position and application of Islamic family law in the country with a minority Muslim population, especially those in England.[Di kalangan umat Islam, tidak ada yang memungkiri eksistensi hukum Islam dengan karakter universalitas keberlakuannya. Hal ini didukung oleh nas} al-Qur’an surat al-Anbiya>’ (21) ayat 107. Universilitas keberlakuan hukum Islam meniscayakan ketundukan semua pemeluk Islam pada ajaranajaran Islam, dimanapun dan kapan pun mereka berada, dan juga meniscayakan adanya nilai-nilai universal yang terkandung di dalam hukum-hukum cabang yang mungkin berbeda antara satu tempat dan tempat lainnya. Karena itulah umat Islam di negara-negara Islam dan negara yang mayoritas penduduknya beragama Islam relatif tidak menemukan kendala dalam hubungannya dengan aplikasi hukum Islam dalam kehidupan keseharian mereka. Kenyataan di atas tentu berbeda jika hukum Islam berkembang di kalangan muslim yang merupakan minoritas di negara sekuler, yaitu negara dengan sistem pemerintahan yang memisahkan agama sebagai masalah privat. Tulisan ini akan membahas bagaimana posisi dan aplikasi hukum keluarga Islam di negara dengan penduduk Islam minoritas, khususnya di Inggris.]
KONTROVERSI PRAKTEK TAJDI<D AN-NIKA<H{ DALAM PERSPEKTIF FIKIH KLASIK
Authors: Bahri Syaiful 
Published: September 2024

Tajdi>d an-nika>h} is a common tradition practiced by some communities in Indonesia. A controversy on the idea of whether or not the first ‘Akad is married by the second ‘Akad occurs among classical Muslim scholars. This paper attempts to explain the controversy, mainly from point of view of Syafi'iah jurists in various existing references. Therefore, the author did a library research. The author studied various books on Syafi'iah fiqh dealing with the practice of tajdi>d an-nika>h}. The study concluded that the majority of Syafi'iah scholars allowed it and the practice did not destroy the existence of the first contract. The one who rejects the validity of tajdi>d an-nika>h} practice is Yusuf Ibrahim al-Ardabili. In his book, al-Anwa>r, al-Ardabili states that tajdi>d an-nika>h} practice has an affects the status of the first contract, which undermines the existence of the first ‘akad.[Tajdi>d an-nika>h} merupakan tradisi yang lumrah dipraktekkan oleh sebagian masyarakat Indonesia. Ada kontroversi di balik praktek yang populer di kalangan para sarjana Muslim klasik. Kontroversi tersebut terletak pada akad yang pertama apakah dirusak oleh akad yang kedua. Tulisan ini mencoba untuk mengurai kontroversi tersebut, utamanya dilhat dari pandangan para ahli fikih Syafi’iah dalam pelbagai literatur yang ada. Untuk itu, penulis melakukan kajian kepustakaan dengan mengkaji dan meneliti pelbagai literatur fikih Syafi’iah yang berhubungan dengan praktek tajdi>d an-nika>h} ini. Studi ini menghasilkan kesimpulan bahwa mayoritas ulama Syafi’iah berpendapat bahwa hukum tajdi>d an-nika>h} diperbolehkan dan praktek tersebut tidak merusak keberadaan akad yang pertama. Adapun yang menolak keabsahan praktek tajdi>d an-nika>h} ini adalah Yusuf Ibrahim al-Ardabili. Dalam kitabnya, al-Anwar, al-Ardabili menyatakan bahwa praktek tajdi>d an-nika>h} mempunyai dampak terhadap status akad yang pertama, yaitu merusak eksistensi akad pertama tersebut.]
PERKAWINAN SESAMA JENIS DALAM PERSPEKTIF HUKUM ISLAM
Authors: Setyoko Setyoko 
Published: September 2024

Nowadays, Homosexual in Indonesia have been significan on the number and variety. Along with an increase in the number of these, the new interest had emergies from that group, one of these to get legalization of the homosexualrelationship in marriage. As the lawstate (rechtstaat) with moslem majority in that population, most exactly in Indonesia have been rise the discursus, may or no about the act was set the homosexual relationship in marriage, and Islam Law is the main material in this study. This paper attempts to explains about homosexual relationship in marriage studies from some refereence in Islam Law repertoir. The deeply re-study of Qur’an and hadits texts, fuqaha’s opinion, and modern intepretation of fiqh from Musdah Mulia will describes as the material in the making of analyses this problem. The maqasid asy-syariah is the main material to analyses this problem for get the conclution.[Homoseksual di Indonesia dewasa ini sudah cukup signifikan secara jumlah dan variasinya. Seiring dengan peningkatan jumlah tersebut, pastilah berbagai kepentingan baru akan muncul dari kelompok tersebut, sebut saja kepentingan untuk mendapatkan legalisasi hubungan antar-mereka. Sebagai negara hukum (rechstaat) yang berpenduduk mayoritas beragama Islam, maka di Indonesia akan timbul diskursus mengenai mungkin tidaknya sebuah perundang-undangan yang akan mengatur hal tersebut, dan yang menjadi bahan utama untuk kajian adalah hukum Islam. Tulisan ini mengetengahkan berbagai kajian tentang hubungan sesama jenis dari berbagai referensi dalam khazanah hukum Islam.Pendalaman kembali terhadap berbagai teks-teks Qur’an dan Hadis, pendapat-pendapat ulama fikih klasik, serta tafsir-tafsir fikih modern dari Musdah Mulia akan dipaparkan sebagai bahan dalam membuat analisis atas masalah tersebut. Sedangkan maqa>s}id asy-syari>‘ah menjadi materi untuk menganalisis dalam rangka mendapatkan sebuah kesimpulan.]