bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: PREPARATION AND CHARACTERIZATION OF THE COPPER(II) AND ZINC(II) COMPLEXES OF D‐β‐(2‐PYRIDYL)‐α‐ALANINATE AND THEIR CONDENSATION PRODUCTS WITH ACETONE
Authors: EBNER S. R. , ANGELICI R. J. 
Published: April 2016

AbstractDie 1:2‐molare Reaktion von Cu(II)‐ oder Zn(II)‐hydroxid mit D‐β‐(2‐Pyridyl)‐a‐alanin in wäßriger Lösung unter Erwärmen führt zu den Produkten (I).
ChemInform Abstract: DIOXYGEN AND NITRIC OXIDE COMPLEXES OF RHODIUM PORPHYRINS
Authors: WAYLAND B. B. , NEWMAN A. R. 
Published: April 2016

AbstractDas aus dem Chloroderivat (I) über das Hydrid (II) erhaltene Dimere (III) reagiert mit Disauerstoff unter Bildung von (IV) (S = 1/2 ).
ChemInform Abstract: COMPLEXES OF FUNCTIONAL PHOSPHINES. 4. COORDINATION PROPERTIES OF (DIPHENYLPHOSPHINO)ACETONITRILE, ETHYL (DIPHENYLPHOSPHINO)ACETATE AND CORRESPONDING CARBANIONS. CHARACTERIZATION OF A NEW FACILE REVERSIBLE CARBON DIOXIDE INSERTION INTO PALLADIUM(II) COMPLEXES
Authors: BRAUNSTEIN P. , MATT D. , DUSAUSOY Y. , FISCHER J. , MITSCHLER A. , RICARD L. 
Published: April 2016

AbstractDie neutralen Titelliganden (II) reagieren mit den Pd‐Dimeren (I) unter Spaltung der Halogenid‐Brücken zu den monomeren Komplexen (III), in denen sie einzähnig über ihr P‐Atom koordiniert sind.
ChemInform Abstract: SYNTHESIS OF (.+‐.)‐NORAMBREINOLIDE BY CYCLIZATION OF TRANS‐β‐MONOCYCLOHOMOFARNESIC ACID
Authors: SAITO A. , MATSUSHITA H. , TSUJINO Y. , KANEKO H. 
Published: April 2016

AbstractDie Cyclisierung der Säure (I) mit Zinntetrachlorid liefert als Hauptprodukt Norambreinolid (II), das sich bei höherer Temperatur in Norisoambreinolid (III) umlagert.
ChemInform Abstract: SIMPLE SYNTHESIS OF DE‐AB‐CHOLESTA‐8(14),22‐DIEN‐9‐ONE BY HIGHLY STEREOSELECTIVE DOUBLE MICHAEL ADDITION INVOLVING ALKENYLCOPPER‐PHOSPHINE COMPLEX, VINYL KETONE, AND 2‐METHYL‐2‐CYCLOPENTENONE FOLLOWED BY CLAISEN REARRANGEMENT AND RHODIUM‐PROMOTED DECARBONYLATION
Authors: TAKAHASHI T. , NAITO Y. , TSUJI J. 
Published: April 2016

AbstractMichael‐Addition des Komplexes (II) an das Cyclopentenon (I), Umsetzung des resultierenden Enolats mit dem Enon (III), Löschen des Reaktionsgemisches mitNH4Cl, Basen‐induzierte Aldol‐Kondensation der gebildeten Diketone und anschließende Eliminierung der Methoxyisopropyl‐Schutzgruppe führen zu den epimeren Enonen (IV).
ChemInform Abstract: SILYL STEROIDS. III. SYNTHESIS OF 2‐ AND 4‐TRIMETHYLSILYLESTRADIOLS AND THEIR R DERIVATIVES
Authors: GOLUBOVSKAYA L. E. , RZHEZNIKOV V. M. , ZONTOVA V. N. , PIVNITSKII K. K. 
Published: April 2016

AbstractUnter den im Formelschema angegebenen Bedingungen werden die silylierten Östradiolderivate (III), (IV), (VII) und (VIII) erhalten.
ChemInform Abstract: PEPTIDES. XXXXIII. SYNTHESIS OF THE 94‐104 FRAGMENT OF A LYSOZYME ANALOG
Authors: GALPIN I. J. , HUDSON D. , KENNER G. W. , NOBLE P. , RAMAGE R. 
Published: April 2016

AbstractDie Synthese des Titelfragments (VI) erfolgt durch Kondensation der Unterfragmente den synthetisiert: 1. durch schrittweisen Aufbau ausge‐ densation der Komponenten (IIIb) [aus (IIIa)] und (IV) (Darst Überführung des Produkts (Va) in den aktiven Ester (Vb).
ChemInform Abstract: 3‐NITRO‐2‐PYRINEDINESULFENYL GROUP FOR PROTECTION AND ACTIVATION OF THE THIOL FUNCTION OF CYSTEINE
Authors: MATSUEDA R. , KIMURA T. , KAISER E. T. , MATSUEDA G. R. 
Published: April 2016

AbstractDas Boc‐geschützte Cystein (III), dessen Herstellung aus dem Cystin‐Derivat (I) beschrieben ist, wird mit 3‐Nitro‐2‐pyridinsulfensäurechlorid (V) (Npys‐Cl) zum Derivat (VI) umgesetzt.
ChemInform Abstract: BUILDING UNITS FOR OLIGOSACCHARIDES. XXXII. SYNTHESIS OF THE BRANCHED PENTASACCHARIDE UNIT OF THE O‐SPECIFIC SIDE CHAIN OF THE LIPOPOLYSACCHARIDE FROM SHIGELLA DYSENTERIAE
Authors: PAULSEN H. , BUENSCH H. + 
Published: April 2016

AbstractDie Synthese der Titelverbindung (VIIIc) erfolgt durch Verknüpfung des Trisaccharidblocks (IVb) aus 3 Azidozuckern mit dem Disaccharidblock (VIIb) [→(VIIIa)], Abspaltung der Tca‐Gruppe, nachfolgende Reduktion der Azidogruppen (NiCl2/NaBH4) und Acetylierung [→(VIIIb)], Hydrolyse der Acetatreste und hydrogenolytische Debenzylierung.
ChemInform Abstract: STEREOSELECTIVE SYNTHESIS OF (25S)‐25‐HYDROXYVITAMIN D3 26,23‐LACTONE
Authors: YAMADA S. , NAKAYAMA K. , TAKAYAMA H. 
Published: April 2016

AbstractAus der Säure (Ia) entsteht das (S)‐Dimethylcitramalat (Ib), das in der angegebenen Weise zum Provitamin D (V) umgesetzt und dann photochemisch zum Vitamin D3‐Derivat (VI) gespalten wird.
ChemInform Abstract: A NOVEL METHOXY‐DIRECTED KETAL HYDROLYSIS AND ITS APPLICATION TO A CONVERGENT, REGIOSPECIFIC SYNTHESIS OF (.+‐.)‐DAUNOMYCINONE
Authors: DOLSON M. G. , CHENARD B. L. , SWENTON J. S. 
Published: April 2016

AbstractAusgehend von dem Tetralon (I) wird über die Intermediären (IIa)‐(IIc) der Hydroxyester (III) dargestellt und in das Hydroxyketon (IV) umgewandelt, das mit dem Reagenz (V) zu dem Ether (VI) umge‐ 183 setzt wird.
ChemInform Abstract: EFFICIENT SYNTHESIS OF THE GOSSYPOL BINAPHTHYL BACKBONE
Authors: VENUTI M. C. 
Published: April 2016

AbstractEine Synthese des Dinaphthyl‐Gerüstes von Gossypol (VII) geht von 2,3‐Dimethoxy‐isopropylbenzol (Ia) aus, das zum Tetralon (IV) führt.
ChemInform Abstract: KINETICS AND MECHANISM OF THE REACTION OF SUBSTITUTED PHENYLHYDRAZONES WITH THALLIUM(III) ACETATE. REACTIONS OF MERCURY(II) ACETATE WITH NITROGEN COMPOUNDS. PART 8
Authors: BUTLER R. N. , MORRIS G. J. , O'DONOHUE A. M. 
Published: April 2016

AbstractAls Primär‐Reaktion des Hydrazons (I) mit Tl(III)‐acetat ist ein elektrophiler Angriff des Tl(OAc);,‐′‐Ions auf die NH‐Einheit unter Bildung eines Hydraziniumions anzusehen, dem die Anlagerung des Acetoxy‐Anions an das durch Verschiebung der C=N‐Doppelbindung entstandene Carboniumkation unter Bildung der Azo‐Verbindung (II) folgt.
ChemInform Abstract: 1H‐IMIDAZO(4,5‐B)PYRAZINES. III. 2‐THIOLS AND DERIVATIVES
Authors: TONG Y. C. 
Published: April 2016

Abstract2,3‐Diamino‐pyrazine (I) kondensieren mit Harnstoff zu den Oxo‐Verbindungen (II), die mit Phosphorpentasulfid zu (III) geschwefelt werden.
ChemInform Abstract: SYNTHESIS OF SILYL‐SUBSTITUTED VINYLALLENES
Authors: DULCERE J.‐P. , GRIMALDI J. , SANTELLI M. 
Published: April 2016

AbstractAlkinyl‐allylchloride (I) reagieren mit Trimethylchlorsilan (II) in Gegenwart von Li oder Mg über Organometallverbindungen zu den Allen‐olefinen (III).
ChemInform Abstract: THE MECHANISM OF THE PROTODESILYLATION OF ALLYLSILANES WHICH ARE DISUBSTITUTED ON C‐3
Authors: FLEMING I. , MARCHI D. JUN. , PATEL S. K. 
Published: April 2016

Abstract3,3‐Dialkylallylsilane wie (I) und (IV) reagieren mit Protonen durch zwei unterschiedliche Mechanismen, liefern jedoch dieselben Ergebnisse.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF NIOBIUM(III) β‐DIKETONATE DERIVATIVES; MOLECULAR CONSTITUTION OF THEIR SOLUTIONS
Authors: HUBERT‐PFALZGRAF L. G. , TSUNODA M. , KATOCH D. 
Published: April 2016

AbstractDie Reaktion von Nb2C16L4 (L = PMe2Ph) mit Dipivaloylmethan in Methylenchlorid oder THF ergibt unabhängig vom stöchiometri‐ schen Reaktandenverhältnis den Monodiketonato‐Komplex (I).
ChemInform Abstract: PRODUCTION AND STRUCTURAL STUDY OF IODOCUPRATES(I) WITH TETRAHEDRON SURFACE LINKAGE
Authors: HARTL H. , MAHDJOUR‐HASSAN‐ABADI F. 
Published: April 2016

AbstractDie direkte Umsetzung von Cu mit organischen Triiodiden oder mit Iod in Gegenwart der Iodide in organischen Lösungsmitteln führt zu den Verbindungen der Zusammensetzung (I).
ChemInform Abstract: STEREOSELECTIVE, CATALYTIC REDUCTION OF L‐ASCORBIC ACID: A CONVENIENT SYNTHESIS OF L‐GULONO‐1,4‐LACTONE
Authors: ANDREWS G. C. , CRAWFORD T. C. , BACON B. E. 
Published: April 2016

AbstractDurch Hydrierung von L‐Ascorbinsäure (Ia) bzw. D‐Erythorbinsäure (Ib) entstehen das L‐Gulonolacton (IIa) bzw. das D‐Mannonolacton (IIb).
Confirmation of proposed human papillomavirus risk–adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas
Authors: Horne Zachary D. , Glaser Scott M. , Vargo John A. , Ferris Robert L. , Balasubramani Goundappa K. , Clump David A. , Heron Dwight E. , Beriwal Sushil 
Published: April 2016

BACKGROUNDPatients with human papillomavirus (HPV)–related oropharyngeal cancers (OPCs) have superior outcomes in comparison with patients with non–HPV‐induced OPCs. This study confirms that a previously proposed HPV risk–adapted restaging system better reflects disease outcomes.METHODSThe National Cancer Data Base was used to analyze 8803 HPV+ OPC patients. Univariate and multivariate analyses were performed to identify the utility of both American Joint Commission on Cancer (AJCC) staging and HPV risk–adapted staging in predicting the outcomes of patients with HPV+ OPC and other factors influencing survival.RESULTSWith a median follow‐up of 27.1 months, 3.2% had AJCC stage I disease and 6.6%, 19.4%, and 70.9% had stage II, III, and IV disease, respectively. When the patients were restaged according to HPV risk–adapted staging, 76.6% had stage I disease, 9.9% had stage II disease, and 13.5% had stage III disease. The 4‐year overall survival rates according to HPV risk–adapted staging were 85.8%, 77.3%, and 64.6% for stages I, II, and III, respectively, but the rates for AJCC stages I, II, III, and IV were 90.1%, 86.1%, 87.0%, and 80.1%, respectively. Patients with HPV+ metastatic disease at diagnosis had a significantly improved median survival of 20.5 months versus 11.1 months with HPV– disease (P < .01). In the multivariate analysis, survival was also affected by the age at treatment, a nontonsillar or base‐of‐tongue primary site, private insurance, an annual income ≥ $48,000/y, and the comorbidity index (all P values < .01).CONCLUSIONSOutcomes of HPV+ OPC are significantly improved in comparison with HPV– OPC outcomes, and the current AJCC staging system does not accurately reflect disease outcomes. This study has retrospectively confirmed that an HPV risk–adapted restaging structure more accurately stratifies patients. Under this new risk‐stratified staging system, patients may be more accurately stratified for investigation into treatment escalation or de‐escalation studies. Cancer 2016;122:2021–30. © 2016 American Cancer Society.
The g‐C3N4/C2N Nanocomposite: A g‐C3N4‐Based Water‐Splitting Photocatalyst with Enhanced Energy Efficiency
Authors: Wang Huimin , Li Xingxing , Yang Jinlong 
Published: April 2016

AbstractWater‐splitting photocatalysts with good energy efficiency are highly desirable, among which metal‐free graphitic carbon nitride (g‐C3N4) is considered to be very promising and has been intensively studied in recent years. However, its practical application is hindered by the relatively low efficiencies of visible‐light absorption and electron–hole separation. Herein, based on first‐principles calculations, it is predicted that, by forming nanocomposites with another carbon nitride (C2N), the energy efficiency of g‐C3N4 can be significantly improved. On one hand, C2N has a wide, strong optical absorption in the visible‐light region, which acts as a photosensitizer and enhances the photoabsorption efficiency of the composite photocatalyst. On the other hand, C2N forms a type II heterojunction with g‐C3N4, which leads to efficient separation of photogenerated electron–hole pairs through the chemical potential difference between the two components. These results provide a potential route to achieve highly efficient metal‐free photocatalysts for water splitting.
Algorithm for the precise detection of single and cluster cells in microfluidic applications
Authors: Girault Mathias , Hattori Akihiro , Kim Hyonchol , Matsuura Kenji , Odaka Masao , Terazono Hideyuki , Yasuda Kenji 
Published: April 2016

AbstractRecent advances in imaging flow cytometry and microfluidic applications have led to the development of suitable mathematical algorithms capable of detecting and identifying targeted cells in images. In contrast to currently existing algorithms, we herein proposed the identification and reconstruction of cell edges based on original approaches that overcome frequent detection limitations such as halos, noise, and droplet boundaries in microfluidic applications. Reconstructed cells are then discriminated between single cells and clusters of round‐shaped cells, and cell information such as the area and location of a cell in an image is output. Using this method, 76% of cells detected in an image had an error <5% of the cell area size and 41% of the image had an error <1% of the cell area size (n = 1,000). The method developed in the present study is the first image processing algorithm designed to be flexible in use (i.e. independent of the size of an image, using a microfluidic droplet system or not, and able to recognize cell clusters in an image) and provides the scientific community with a very accurate imaging algorithm in the field of microfluidic applications. © 2016 International Society for Advancement of Cytometry
The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development
Authors: Lopez Cecilia I. , Saud Katherine E. , Aguilar Rodrigo , Berndt F. Andrés , Cánovas José , Montecino Martín , Kukuljan Manuel 
Published: April 2016

ABSTRACTThe development of the cerebral cortex is a dynamic and coordinated process in which cell division, cell death, migration, and differentiation must be highly regulated to acquire the final architecture and functional competence of the mature organ. Notch pathway is an important regulator of differentiation and it is essential to maintain neural stem cell (NSC) pool. Here, we studied the role of epigenetic modulators such as lysine‐specific demethylase 1 (LSD1) and its interactor CoREST in the regulation of the Notch pathway activity during the development of the cerebral cortex. We found that CoREST and LSD1 interact in vitro with RBPJ‐κ in the repressor complex and these proteins are released upon overexpression of Notch intracellular domain (NICD). We corroborated LSD1 and RBPJ‐κ interaction in developing cerebral cortex and also found that LSD1 binds to the hes1 promoter. Knock‐down of CoREST and LSD1 by in utero electroporation increases Hes1 expression in vivo and decreases Ngn2. Interestingly, we found a functional interaction between CoREST and LSD1 with Notch pathway. This conclusion is based on the observation that both the defects in neuronal migration and the increase in the number of cells expressing Sox2 and Tbr2 were associated to the knock‐down of either CoREST or LSD1 and were reversed by the loss of Notch. These results demonstrate that CoREST and LSD1 downregulate the Notch pathway in the developing cerebral cortex, thus suggesting a role of epigenetic regulation in the fine tuning of cell differentiation. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1360–1373, 2016
Hepatocyte nuclear factor‐4 alpha in noise‐induced cochlear neuropathy
Authors: Groth Jane Bjerg , Kao Shyan‐Yuan , Briët Martijn C. , Stankovic Konstantina M. 
Published: April 2016

ABSTRACTNoise‐induced hearing loss (NIHL) is a problem of profound clinical significance and growing magnitude. Alarmingly, even moderate noise levels, previously assumed to cause only temporary shifts in auditory thresholds (“temporary” NIHL), are now known to cause cochlear synaptopathy and subsequent neuropathy. To uncover molecular mechanisms of this neuropathy, a network analysis of genes reported to have significantly altered expression after temporary threshold shift‐inducing noise exposure was performed. The transcription factor Hepatocyte Nuclear Factor‐4 alpha (HNF4α), which had not previously been studied in the context of cochlear response to noise, was identified as a hub of a top‐ranking network. Hnf4α expression and localization using quantitative RT‐PCR and in situ hybridization, respectively, were described in adolescent and adult mice exposed to neuropathic noise levels in adolescence. Isoforms α3 and α12 in the cochlea were also identified. At every age examined, Hnf4α mRNA expression in the cochlear apex was similar to expression in the base. Hnf4α expression was evident in select cochlear cells, including spiral ganglion neurons (SGNs) and hair cells, and was significantly upregulated from 6 to 70 weeks of age, especially in SGNs. This age‐related Hnf4α upregulation was inhibited by neuropathic noise exposure in adolescence. Hnf4α silencing with shRNA transfection into auditory neuroblast cells (VOT‐33) reduced cell viability, as measured with the MTT assay, suggesting that Hnf4α may be involved in SGN survival. Our results motivate future studies of HNF4α in cochlear pathophysiology, especially because HNF4α mutations and polymorphisms are associated with human diseases that may include hearing loss. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1374–1386, 2016
Titanium Carbide Nanoparticle‐Decorated Electrode Enables Significant Enhancement in Performance of All‐Vanadium Redox Flow Batteries
Authors: Wei Lei , Zhao Tianshou , Zeng Lin , Zhou Xuelong , Zeng Yikai 
Published: April 2016

AbstractIn this work, we demonstrate that titanium carbide (TiC) nanoparticles exhibit high catalytic activity for the redox reaction of V3+/V2+ in acid solution. TiC nanoparticles enable the oxidation peak potential to be negatively shifted by 100 and 183 mV relative to that of pure carbon nanoparticles and that of pristine carbon paper, respectively. A TiC nanoparticle decorated carbon paper electrode is prepared and used as the negative side of a single vanadium redox flow battery. The battery demonstrates an energy efficiency of 80.7 % at a high current density of 100 mA cm−2; this value is 12.3 % higher than that of the battery with the pristine electrode. The findings presented in this work suggest that titanium carbide nanoparticle decorated carbon paper exhibits great promise as a high‐performance electrode for vanadium redox flow batteries.
Penetrance of ATM Gene Mutations in Breast Cancer: A Meta‐Analysis of Different Measures of Risk
Authors: Marabelli Monica , Cheng Su‐Chun , Parmigiani Giovanni 
Published: April 2016

ABSTRACTThe gene responsible for ataxia‐telangiectasia syndrome, ATM, is also an intermediate‐risk breast cancer (BC) susceptibility gene. Numerous studies have been carried out to determine the contribution of ATM gene mutations to BC risk. Epidemiological cohorts, segregation analyses, and case‐control studies reported BC risk in different forms, including penetrance, relative risk, standardized incidence ratio, and odds ratio. Because the reported estimates vary both qualitatively and quantitatively, we developed a general model allowing the integration of the different types of cancer risk available in the literature. We performed a comprehensive meta‐analysis identifying 19 studies, and used our model to obtain a consensus estimate of BC penetrance. We estimated the cumulative risk of BC in heterozygous ATM mutation carriers to be 6.02% by 50 years of age (95% credible interval: 4.58–7.42%) and 32.83% by 80 years of age (95% credible interval: 24.55–40.43%). An accurate assessment of cancer penetrance is crucial to help mutation carriers make medical and lifestyle decisions that can reduce their chances of developing the disease.
Psychotropic drugs and the risk of fall injuries, hospitalisations and mortality among older adults
Authors: Johnell Kristina , Jonasdottir Bergman Gudrun , Fastbom Johan , Danielsson Bengt , Borg Natalia , Salmi Peter 
Published: April 2016

ObjectiveTo investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults.MethodsWe performed a nationwide matched (age, sex, and case event day) case–control study between 1 January and 31 December 2011 based on several Swedish registers (n = 1,288,875 persons aged ≥65 years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co‐morbidity index, dementia and number of other drugs.ResultsAntidepressants were the psychotropic most strongly related to fall injuries (ORadjusted: 1.42; 95% CI: 1.38–1.45) and antipsychotics to hospitalizations (ORadjusted: 1.22; 95% CI: 1.19–1.24) and death (ORadjusted: 2.10; 95% CI: 2.02–2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted: 1.53; 95% CI: 1.39–1.68), hospitalization (4 psychotropics vs 0: ORadjusted: 1.27; 95% CI: 1.22–1.33) and death (4 psychotropics vs 0: ORadjusted: 2.50; 95% CI: 2.33–2.69) in a dose–response manner. Among persons with dementia (n = 58,984), a dose–response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted: 1.99; 95% CI: 1.76–2.25).ConclusionsOur findings support a cautious prescribing of multiple psychotropic drugs to older patients. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.
Amyloid burden and incident depressive symptoms in cognitively normal older adults
Authors: Harrington Karra D. , Gould Emma , Lim Yen Ying , Ames David , Pietrzak Robert H. , Rembach Alan , Rainey‐Smith Stephanie , Martins Ralph N. , Salvado Olivier , Villemagne Victor L. , Rowe Christopher C. , Masters Colin L. , Maruff Paul ,   for the AIBL Research Group
Published: April 2016

ObjectiveSeveral studies have reported that non‐demented older adults with clinical depression show changes in amyloid‐β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54‐month prospective observation period.MethodsCognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18‐month intervals over 54 months.ResultsWhilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54‐month assessment.ConclusionsResults of this study suggest that elevated Aβ levels are associated with a 4.5‐fold increased likelihood of developing clinically significant depressive symptoms on follow‐up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ. Copyright © 2016 John Wiley & Sons, Ltd.