bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of adult renal cell carcinoma types presenting to a tertiary care hospital in Sri Lanka and the intraobserver variability of two nuclear grading systems for clear cell renal cell carcinoma
Authors: Gunawardena Labandi Malhasi , Jayawickrama Modini Manohari Abeydera , Lokuhetty Menaka Dilani Samarawickrema 
Published: September 2024

: The histomorphology remains the foundation in classification of renal cell carcinoma (RCC). The nuclear grading is significant in prognostication of certain subtypes for which Fuhrman system was used before the introduction of WHO/ISUP system in 2012. : To describe types of adult RCC presenting to a tertiary care hospital in Sri Lanka and to assess intraobserver variability of two nuclear grading systems for clear cell RCC.: One representative H and E stained slide from all RCC reported in National Hospital of Sri Lanka and University of Colombo, Sri Lanka from 2016-2020 were selected (n = 228). Tumours were classified by morphology according to WHO-5th series. Two rounds each of nuclear grade assessment using Fuhrman and WHO/ISUP systems were performed on clear cell RCC (n = 189) to calculate intraobserver agreement using kappa index (SPSS 25.0). Of the 228 cases 189 were of clear cell (82.9%), 24 were papillary (10.5%) and 6 were chromophobe (2.6%). Seven were identified requiring molecular testing for accurate diagnosis (3.1%). Kappa value was 0.953 for WHO/ISUP (95% confidence interval 0.916 – 0.99) and 0.856 for Fuhrman system (95% confidence interval 0.794 – 0.918). Majority of the RCC were clear cell, followed by papillary and chromophobe. Other subtypes were rare. A few required molecular testing for diagnosis. WHO/ISUP system showed an almost perfect level of intraobserver agreement. Although discordant with many studies, Fuhrman system also demonstrated a strong level of intraobserver agreement.
The immunophenotypic and clinicohematological characteristics of T-ALL cases detected over a three-year period in a tertiary institution
Authors: Banashree Rajkumari , Sharma Taniya , Thiyam Urmila , Thangjam Shitalmala , Singh Irom Anil , Singh Kshetrimayum Achouba 
Published: September 2024

: A malignant tumor of immature T cells, T-cell acute lymphoblastic leukemia/lymphoma is known by this acronym, T-ALL. 12-15% percent of all cases of acute leukemia are T-ALL. According to the 2017 WHO classification, early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL) is a unique and uncommon condition. It includes 17–22% of adult T-ALL cases and 12–16.2% of childhood T-ALL cases.: To examine the immunophenotypic and clinicohematologic features of T-ALL.: A retrospective analysis was conducted on all acute leukemia diagnoses made in the Pathology Department, Jawaharlal Nehru Institute of Medical Sciences, Imphal between June 2020 and June 2023, a period of three years. After completing all required tests, such as a CBC and a bone marrow examination, flow cytometric immunophenotyping was performed either from peripheral blood or the bone marrow aspirate. For immunophenotyping, a 11 color flowcytometer (BECKMAN COULTER) was utilized. Markers for T cell lymphoid lineage included CD3, CD5, CD4, CD7, CD8, and cCd3 while markers for B cell lineage included CD19, CD20, CD22, CD10 and cCD79a. Regarding the myeloid markers, CD117, CD13,CD38, and Myeloperoxidase ; the immaturity markers such as CD 34 and HLA-DR; and the monocytic markers CD33, CD14, CD64 and CD11c were used. ETP-ALL diagnosis was accomplished using specific scoring systems.: Out of the 150 acute leukemia cases that were diagnosed during this time, 15 (10%) were categorized as T-ALL according to WHO guidelines. Median age was calculated as 17 (range: 4–60 years). 11/15 (73.3%) of the cases were male, and 4/15 (26.6%) were female. Of the 4 female cases, 2 were found to have ETP-ALL. This study was carried out since there is a dearth of data from this region of the nation. Furthermore, because ETP-ALL cases have a bad prognosis, it is important to get a thorough diagnosis.
Studies of malignant & non-malignant lung lesions detected by USG guided FNAC in the Saurashtra region
Authors: Berani Jaysukhkumar , Dalsania J D , Dhruva Gauravi 
Published: September 2024

USG Guided fine needle aspiration cytology (FNAC) is a minimally invasive procedure used to obtain cellular samples from lung lesions for diagnostic purposes. With the help of ultrasound (USG) accurately guide the needle to the target area, ensuring precise and effective sampling. It is safe, less traumatic, quick and cost-effective tool being minimally invasive & excellent patient’s compliance. : Studies of Malignant & Non-malignant Lung Lesions Detected by USG Guided FNAC. 58 patients come for USG Guided FNAC to P.D.U. hospital was studied in the duration of year November 2021- October 2022. : Out of 58 cases 79.31% were male. Maximum case present in quinquagenarian age group. 67.24% having malignant lesions and 25.86% have non-malignant lesions, 8.62% was inconclusive aspirated. Squamous cell carcinoma was identified as the most common malignant tumor. : USG Guided FNAC provides a reliable diagnosis of pulmonary lesions, reducing morbidity and mortality, and allowing for early initiation of treatment.
A case of inflammatory myofibroblastic tumor of small intestine, presented as intussusception
Authors: Muppidi Keerthana , Vaibhav Takkalapally Prasanna 
Published: September 2024

Inflammatory myofibroblastic tumor (IMT) is a soft tissue tumor of intermediate malignant potential with a prominent inflammatory infiltrates, consisting of mainly lymphocytes and plasma cells.The small intestine and colon are most commonly involved in the gastrointestinal tract followed by the stomach. The oesophagus, pancreas, appendix and liver are rare sites. Patients present with abdominal pain, bowel obstruction and fever in many cases. Children and young adults are most commonly affected. Etiology is unknown.A 23-year-old female presented with pain abdomen, constipation and bleeding per rectum. X-ray erect showed dilated bowel loops. Ultrasound and CECT abdomen suggested ileocaecal intussusception and features of bowel obstruction. Patient was posted for exploratory laparotomy and ileocaecal segment excision was done. Histopathological examination revealed a mass attached to small intestine and microscopic examination of mass showed inflammatory myofibroblastic tumor.Histopathological examination remains the gold standard for diagnosis of such cases presenting with intestinal obstruction. Small intestinal IMT is very rare.
EXPLORING VIVEKANANDA’S PLURALISM AND UNIVERSALISM IN THE CONTEXT OF ISLAM: A CRITICAL ANALYSIS
Authors: Zaheer Nosheen , Durrani Asiya , Shah Masooda , Rukhsana Rukhsana 
Published: September 2024

Purpose of the study: To explore Swami Vivekananda's pluralism and universalism in the context of Islam, examining whether his writings align with his claimed pluralism when discussing Islam and Prophet Muhammad (P.B.U.H.).
Methodology: This qualitative research involves systematically collecting and analyzing Swami Vivekananda’s views on pluralism, universalism, and Islam from his writings in The Complete Works of Swami Vivekananda. Vivekananda's perspectives will be evaluated against primary Islamic sources, specifically the Quran and Hadith, to assess the consistency of his ideology with his claims of pluralism and universalism.
Main Findings: The research findings indicate that Swami Vivekananda's approach to Islam is neither pluralistic nor universalistic. While he sought to reform Hinduism as a monotheistic religion through Vedanta philosophy, his attitude toward Islam and Prophet Muhammad (P.B.U.H.) was largely critical and unfriendly, influenced by the context of Hindu mass conversions to Islam.
Applications of the study: This study provides insights into the alignment between Swami Vivekananda’s claimed pluralism and universalism and his actual views on Islam and Prophet Muhammad (P.B.U.H.). It offers a critical perspective on the historical and ideological interactions between Hinduism and Islam in 19th-century Bengal, contributing to a deeper understanding of religious reform and interfaith dynamics.
Novelty/Originality of the study: This study offers a novel examination of Swami Vivekananda’s pluralism and universalism by analyzing his writings on Islam and Prophet Muhammad (P.B.U.H.), revealing insights into the alignment of his philosophical ideals with his views on other religions and addressing gaps in understanding his interfaith approach within 19th-century Bengali religious reform.
Reforçamento natural e reforçamento arbitrário
Authors: Vilares João Eduardo Cattani 
Published: September 2024

A área voltada para pesquisas e intervenções sobre comportamentos socialmente relevantes conhecida como análise do comportamento aplicada preocupa-se, dentre outros aspectos, com a generalidade de suas intervenções. A generalidade refere-se à possibilidade de um comportamento novo permanecer ocorrendo ao longo do tempo, em diferentes contextos. Para que comportamentos continuem ocorrendo, eles precisam ser reforçados, ainda que esporadicamente. Os conceitos conhecidos como reforçamento natural e reforçamento arbitrário indicam maneiras de como os reforçadores podem ser utilizados para atingir certas dimensões da análise do comportamento aplicada, como a generalidade. Além disso, podem permitir uma análise mais detalhada de episódios comportamentais, um planejamento de intervenções que podem ser mais bem adaptadas ao repertório de cada indivíduo, reflexões sobre aspectos éticos de tais intervenções dentre outros aspectos. O presente artigo tem por objetivo sintetizar, de forma didática, os conceitos de reforçamento natural e arbitrário baseados na literatura desenvolvida por Ferster, seu originador, e de autores que contribuíram recentemente com a elaboração dos conceitos de modo a contribuir para a formação conceitual em nível de graduação e pós-graduação em análise do comportamento. O leitor encontrará neste texto diversos exemplos, quadros, tríplices contingências e questões para estudo. Espera-se que uma maior uniformidade no uso dos termos reforçamento natural e reforçamento arbitrário possam trazer maior precisão conceitual para dentro da comunidade de analistas do comportamento e possam se estender também para outras áreas de conhecimento. Palavras-chave: reforçamento natural, reforçamento arbitrário, reforçamento extrínseco, reforçamento intrínseco, análise do comportamento aplicada.
L' agriculture et les agriculteurs chez Aristote
Authors: Helmer Etienne 
Published: September 2024

Si Xénophon dans l’Économique et Platon dans les Lois prônent sans réserve l’intégration politique de l’agriculture et des agriculteurs, le cas d’Aristote dans les Politiques, c’est notre thèse, est différent. S’il fait de l’agriculture l’activité économique principale de toute cité juste pour des raisons à la fois empiriques et métaphysiques, la question de savoir qui doit l’exercer reste problématique : tandis que l’idéal serait à ses yeux que des esclaves ou des populations étrangères s’en chargent afin que les hommes libres se consacrent exclusivement aux affaires politiques, la réalité du monde grec conduit bien souvent les hommes libres à participer eux-mêmes aux tâches agricoles et à délaisser les fonctions politiques. En ce sens, les Politiques d’Aristote témoignent d’une intégration politique limitée et problématique des agriculteurs, entre inclusion et exclusion, et invitent à s’interroger sur la distribution et les relations des fonctions politiques et économiques dans la cité.
PENURUNAN LOGAM Fe PADA PENGOLAHAN LUMPUR LIMBAH MENGGUNAKAN CACING LUMBRICULUS sp.
Authors: Afrianisa Rodu Dhuha 
Published: September 2024

Lumpur hasil pengolahan limbah industri sering mengandung logam berat, polutan organik dan bakteri patogen. Fe (besi) merupakan logam yang bila dalam jumlah besar di lingkungan dapat menyebabkan toksik. Pengololahan lumpur menggunakan cacing akuatik merupakan alternatif dalam mengurangi jumlah lumpur yang dihasilkan dari suatu instalasi pengolahan air limbah. Lumbriculus sp. mampu mengakumulasi logam secara biologis (bioakumulasi) yang selanjutnya dapat terjadi pengurangan logam berat dalam lumpur. Penelitian dilakukan dengan menambahkan cacing Lumbriculus sp. pada lumpur dari unit reservoir IPAL. Rasio berat cacing/lumpur dalam pengolahan yang digunakan adalah 0,4; 0,6; dan 0,8. Pengamatan penurunan kadar Fe pada lumpur dilakukan setiap hari selama 7 hari. Hasil dari penelitian ini menunjukkan adanya penurunan Fe pada lumpur pada hari ke 7 sebesar 15,44% rasio 0,6 dan 21,87% rasio 0,8. Terjadi perbedaan pada rasio 0,4 penurunan logam Fe sebesar 21,09% pada hari ke 6.
ANALISIS LIMPASAN PERMUKAAN DI SEKITAR KAMPUS UNIVERSITAS MUHAMMADIYAH SORONG KOTA SORONG
Authors: Farida Anif , Aryuni Vrita Tri 
Published: September 2024

Daerah sekitar Kampus Universitas Muhammadiyah Sorong didominasi oleh kawasan terbangun dan menyisakan sedikit untuk vegetasi (pohon). Pembangunan lahan terbangun dan penutupan permukaan tanah dengan material yang diperkeras berpotensi menyebabkan tingginya limpasan permukaan (surface runoff) di daerah tersebut. Tujuan penelitian ini adalah menghitung besarnya nilai koefisien aliran dan debit limpasan permukaan (surface runoff) yang ada di sekitar Kampus Universitas Muhammadiyah Sorong. Teknik analisis yang digunakan dalam penelitian ini adalah analisis kuantitatif. Nilai koefisien aliran ditentukan dengan rata-rata tertimbang dan berdasarkan penutup lahan. Debit limpasan permukaan dihitung dengan persamaan Rasional. Hasil penelitian menunjukkan bahwa koefisien aliran dipengaruhi oleh penutup lahan. Nilai koefisien aliran total sebesar 0,53 yang berarti 53 % dari hujan yang jatuh menjadi limpasan permukaan. Debit limpasan permukaan paling tinggi pada kejadian hujan tanggal 17 Oktober 2019 sebesar 1,2 m³/detik dengan intensitas hujan 33,69 mm/jam, sedangkan paling rendah tanggal 30 September 2019 sebesar 0,202 m³/detik dengan intensitas hujan 5,67 mm/jam.
Los observatorios turísticos como organismos claves para la gestión de destinos
Authors: DOUMET CHILÁN NEME YAMIL , CRUZ ROMERO BARTOLO , TORRES APOLO DAILY , ALCÍVAR ALAVA FERDINAN 
Published: September 2024

Este trabajo tiene como objetivo,fundamentar mediante un diagnóstico la necesidad e importancia de un observatorio turístico en la región norte de la provincia de Manabí (Ecuador), obteniendo, asimismo, conclusiones trasladables a otros destinos regionales. La investigación es de carácter mixto, con enfoque exploratorio descriptivo. Primero se buscó caracterizar el territorio, identificando sus componentes turísticos y mediante la técnica de revisión bibliográfica y documental, se analizaron las estadísticas nacionales y regionales sobre economía y turismo, confirmando que Manabí posee un 10% de las empresas de alojamiento y restaurantes del país, cuya principal modalidad es el turismo de sol y playa, además de cuantificar una oferta de hospedaje de 6.176 plazas. Posteriormente, se realizó un análisis de la percepción de los gestores sobre el interés en la creación de un observatorio turístico mediante 30 encuestas aplicadas en los ocho cantones estudiados, implementándose un análisis estadístico descriptivo utilizando la herramienta Google forms y el software de análisis estadístico SPSS para su sistematización. El estudio demuestra que el 82.5% de los encuestados tienen interés en proporcionar información disponible sobre la oferta y demanda y el 38.60% acepta ayudar con la aplicación de instrumentos para el levantamiento de datos. Se pudo evidenciar la carencia de información y la necesidad de un observatorio turístico para el uso de datos actualizados y fiables fomentando la adecuada gestión de los destinos en la zona norte de Manabí.
Palabras clave: Información turística, gestión eficiente, observatorios turísticos, destinos.
La significación del Parque Museo “La Venta” como producto de turismo cultural en Tabasco (México)
Authors: PÉREZ SÁNCHEZ BEATRIZ , GARCÍA MUÑOZ APARICIO CECILIA 
Published: September 2024

La evolución de la cultura Olmeca, primera civilización de Mesoamérica, heredó a México el patrimonio de su arquitectura, fiestas, rituales, artesanías, gastronomía y lenguas que surgieron de su diversificación. En Tabasco se edificó y se resguarda el centro ceremonial más antiguo cuyo esplendor se remonta a los años 800-400 a.C. Una simbología que es parte del turismo cultural de Tabasco que fundó el 4 de marzo de 1958 el Parque Museo La Venta, en Villahermosa, un patrimonio de la cultura que constituye una organización civilizadora con elementos de identidad y una atracción turística que brinda autenticidad histórica y prehispánica. Ofrece desde hace más de 60 años un destino arqueológico innovador, diseñado en medio de la naturaleza, de un trópico húmedo con su flora y su fauna original. Objetivo: demostrar la importancia del Parque Museo La Venta como parte del turismo cultural en Tabasco México. Metodología: En esta investigación se utilizará un método de tipo cualitativo descriptivo con el manejo de fuentes secundarias. Resultados: bajo la tutela del Estado mexicano se determinó en toda su amplitud la noción de museo y la creación del Parque Museo La Venta bajo la mercantilización de la cultura.
Palabras Clave: Parque Museo La Venta, turismo cultural, Tabasco, México.
WITHDRAWN: Catecholamines in healthy and inflamed pulp of primary teeth
Authors: Damle Satyawan G , Chopal Nilika , Kamboj Gaurav , Dhindsa Abhishek , Sakhare Dhanashree , Dasgupta Shreya 
Published: September 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
CircPSD3 Aggravates Tumor Progression by Maintaining TCA Cycle and Mitochondrial Function via Regulating SUCLG2 in Thyroid Carcinoma
Authors: Hong Shubin , Sun Yijia , Han Beinan , Ge Jiawei , Huo Zijun , Li Jin , Lin Bo , Du Xin , Zhang Yimin , Weng Haiyan , Yu Shuang , Li Yanbing , Xiao Haipeng , Lin Xiaorong 
Published: September 2024

Abstract

In recent years, there has been a rapid increase in the incidence of thyroid carcinoma (TC). Our study focuses on the regulatory effect of circular RNAs on metabolism of TC, aiming to provide new insights into the mechanisms of progression and a potential therapeutic target for TC. In this study, we identified high expression levels of circPSD3 in TC tissues through RNA sequencing. Papillary thyroid cancer tissue cohorts verified the circPSD3 expression level was positively correlated with larger tumor size. circPSD3 promoted the proliferation of TC cells and reduced apoptosis both in vitro and vivo. Proteomics and metabolomics suggested that circPSD3 might play a crucial role in regulating the tricarboxylic acid (TCA) cycle. Specifically, circPSD3 acted as a miR-338-5p sponge to upregulate SUCLG2, an enzyme of the TCA cycle, accelerates the conversion of α-ketoglutarate (α-KG) to succinate. Knockdown of circPSD3 disrupts the TCA cycle and impairs mitochondrial function, resulting in decreased membrane potential and aerobic respiration rate. The reduction in mitochondrial function resulted in the inhibition of proliferation and initiation of mitochondria-mediated apoptosis.
Construction and Application of Geographic Knowledge Graph for Landslide Disaster Emergency
Authors: Zhao Xiangwei , Kong Xianghui , Zhao Huiji , Gao Lei , Niu Chong 
Published: September 2024

Abstract

Landslide is a common geological disaster worldwide, causing significant harm to human lives, socio-economic development, and the ecological environment. Effective emergency response to landslide requires coordination among multiple departments, while the complex terrain and dam aged roads at disaster sites increase the difficulty of rescue operations. Geographic knowledge graph technology can represent multiple disaster response data in graph form to highlight the complete relationships between the integrated entities. It enhances systematic processing of disaster information to provide scientific decision support for emergency responses. The previous studies on knowledge graph for landslide disaster emergency focused on cause analysis and spatio temporal evolution by using textual data. However, they lacked descriptions of spatial relationships and systematic analysis, which limited their practical application. To solve this problem, a geographic knowledge graph was proposed for landslide emergency response and was implemented in Zhouqu County in China, a region prone to landslides. Firstly, a unified ontology framework was defined, including three ontology concepts named as static base map layer, real-time data layer, and domain information layer, along with spatial, hierarchical, and semantic relationships. Then, the entities, relationships among them, and their attributes were extracted from the data of road networks, emergency response points of interest, and real-time data to form two types of triples including entity-relationship-entity and entity-attribute-value. Next, the ontology alignment methods were applied to eliminate redundant information. The triples were mapped into the unified ontology framework and stored in the Neo4j graph database, forming the geographic knowledge graph for landslide emergency response. Finally, the geographic knowledge graph was used for landslide emergency task assignment and route planning. The experimental results showed that
the geographic knowledge graph for landslide emergency response can be effectively extracted and constructed based on the proposed method by integrating multiple spatial data, and it can perform well for decision support.
Method for assessing the height and three-dimensional spatial development characteristics of water-conducting fissure zones in integrated medium-thickness coal seam mining
Authors: zhao lijuan , zhou junqian , gao mingzhong , wang xingui , duan hongfei , lv wenling , Yu Zhenjian , xie jing , cui pengfei , hu jianjun , Hao Haichun , chi mingbo 
Published: September 2024

Abstract

It is of great significance to accurately grasp the development height of the water-conducting fissure zone (WCFZ) in the rock layer overlying mining airspace, which is of great importance for achieving safe mining of the working face in a mine. In this paper, data on the distribution characteristics of the WCFZs in 40 mines in China were collected, and multivariate linear fitting analysis of the data was carried out using the SPSS software to establish a prediction model for the height of a WCFZ in integrated medium-thickness coal seam mining. Taking working face 2108 in the Heilongguan Coal Mine in Shanxi as the research object, the quantitative interpretation of the development height and distribution characteristics of the WCFZ in the rock overlying the mining airspace was carried out using the method of actual measurement of the amount of leakage of water injected through the drilling holes and the fast Lagrangian code in 3 dimensions (FLAC3D) numerical simulation method to verify the validity of the prediction model for the height of the WCFZ in comprehensive medium-thickness coal seam mining. The study shows that A multivariate linear regression model for calculating the height of a WCFZ was established.The maximum vertical heights of the plastic deformation zones obtained from field tests of water injection leakage in actual engineering boreholes and numerical simulation methods are basically consistent with the results of the model proposed in this paper. the height and spatial development morphology of the WCFZ obtained using the three methods are in good agreement.