bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Beale Number to Pole Placement Design of a Free Piston Stirling Engine
Authors: Zare Shahryar , Tavakolpour-Saleh Alireza , Omidvar Amir 
Published: December 2017

Abstract
In this paper, pole placement-based design and analysis of a free piston Stirling engine (FPSE) is presented and compared to the well-defined Beale number design technique. First, dynamic and thermodynamic equations governing the engine system are extracted. Then, linear dynamics of the free piston Stirling engine are studied using dynamic systems theory tools such as root locus. Accordingly, the effects of variations of design parameters such as mass of pistons, stiffness of springs, and frictional damping on the locations of dominant closed-loop poles are investigated. The design procedure is thus conducted to place the dominant poles of the dynamic system at desired locations on the s-plane so that the unstable dynamics, which is the required criterion for energy generation, is achieved. Next, the closed-loop poles are selected based on a desired frequency so that a periodical system is found. Consequently, the design parameters, including mass and spring stiffness for both power and displacer pistons, are obtained. Finally, the engine power is calculated through the proposed control-based analysis and the result is compared to those of the experimental work and the Beale number approach. The outcomes of this work clearly reveal the effectiveness of the control-based design technique of FPSEs compared to the well-known approaches such as Beale number.
M. K. Čiurlionis and St. Petersburg: New Facts Concerning His PaintingBlack Sun
Authors: Nunokawa Yumiko 
Published: December 2017

SummaryIt is a well-known fact among Lithuanian scholars of studies on Mikalojus Konstantinas Čiurlionis (1875–1911) that Igor Stravinsky (1882–1971) once owned Čiurlionis’ paintingBlack Sun(orBallad). However, it is known only by a reproduction printed in a Russian art magazineАполлон[Apollon]1, with a titleConte fantastiqueandСказка[Fairy Tale] and Stravinsky was specified as an owner of the painting and other details have not been well-researched. Even though some researchers visited St. Petersburg to find the painting several years ago, yet no trace was ever found. In this article, first we would like to look back at Čiurlionis’ visits to St. Petersburg and then, reveal new facts on concerts in which Čiurlionis’ music was performed and more over concerning Čiurlionis’ paintingBlack Sunhow Stravinsky became interested in the painting by introducing letters exchanged between Stravinsky, Alexandre Benois and Andrey Rimsky-Korsakov.
Contemporary Lithuanian Artists: Career Opportunities
Authors: Mačianskaitė Vilma 
Published: December 2017

SummaryBy analysing the careers of internationally recognized artists from Lithuania and the relationship between Lithuanian contemporary artists and art galleries and museums, the author explores the challenges faced by today’s artists and hypothetically underlines the principles that could be useful for them in seeking to enter into the global art scene.The essay analyses the lack of cooperation between artists and galleries, and the representation of artists in Lithuanian museums, which is considered to be the base of a contemporary artist’s career. The essay assesses the influence of the main participants in the art market upon artists’ careers, by investigating the Lithuanian art market’s position after the restoration of independence in 1990. Twenty Lithuanian artists, major galleries or representatives of museums (such as the National Art Gallery and the MO Museum, formerly known as the Modern Art Centre) were interviewed for the purposes of this study.This examination of the Lithuanian art market reveals the peculiarities that artists have encountered, and could help international art market players to better understand the problems that the Lithuanian art market is facing. The author seeks to identify the main factors helping artists to navigate the global art scene and the global art market.
The crystal structure of (E)-2-((2-(o-tolylcarbamothioyl)hydrazono)methyl)benzoic acid, C16H15N3O2S
Authors: Xi-Shi Tai , Peng-Fei Li , Qing-Yun Liu 
Published: December 2017

Abstract
C16H15N3O2S, triclinic, P1̄ (no. 2), a = 7.6394(15) Å, b = 9.2445(18) Å, c = 11.428(2) Å, α = 98.75(3)°, β = 106.34(3)°, γ = 91.18(3)°, V = 763.7(3) Å3, Z = 2, R
gt(F) = 0.0548, wR
ref(F
2) = 0.1411, T = 293(2) K.
Crystal structure of tetramethyl 5,5′-(buta-1,3-diyne-1,4-diyl)diisophthalate, C24H18O8
Authors: Lu Xinhua , Hu Jin , Zhu Caixia 
Published: December 2017

Abstract
C24H18O8, monoclinic, P21/n (no. 14), a = 3.9930(7) Å, b = 26.483(5) Å, c = 10.3307(19) Å, β = 98.136(4)°, V = 1081.5(3) Å3, Z = 2, R
gt(F) = 0.0606, wR
ref(F2) = 0.1986, T = 293(2) K.
Insider Status and Outsider Tactics: Advocacy Tactics of Human Service Nonprofits in the Age of New Public Governance
Authors: Almog-Bar Michal 
Published: December 2017

AbstractPolicy advocacy is an eminent feature of the activities of non-profit human service organizations (NPHSOs), allowing them to represent their constituencies, in addition to their core activity as providers of social services in welfare states. The article presents findings on the advocacy tactics of 47 NPHSOs in Israel, focusing on the ways in which partnership policies in the age of New Public Governance affect their activities. The findings reveal that the shift towards increased governmental funding and contracting-out to nonprofits, as part of the NPG scheme, increases opportunities for the NPHSOs to influence public policy, using a wide variety of both insider cooperative tactics and more confrontational outsider tactics. NPHSOs are firstly concerned with establishing their insider status, using cooperative tactics. After achieving this goal, they feel confident enough to turn to more aggressive outsider tactics, utilizing their relative power as major providers of social services.
Seven Species of Freshwater Lichen-Forming Fungi Newly Recorded from Poland
Authors: Matura Natalia , Krzewicka Beata , Flakus Adam 
Published: December 2017

Abstract
This paper presents seven freshwater lichen species from Western Carpathian streams: Bryobilimbia ahlesii (Körb.) Fryday et al., Rhizocarpon sublavatum Fryday, Thelidium circumspersellum (Nyl.) Zschacke, T. klementii Servít, T. pluvium Orange, T. rehmii Zschacke and Verrucaria devensis (G. Salisbury) Orange. All of them are first records for Poland. Thelidium klementii is new for the Carpathians and was previously known only from the type locality in Germany. Morphological descriptions based on Polish specimens are presented, and the ecology and geographical distribution of these lichens are briefly discussed.
Geisterstunde. Magie, Machtprobe und Herrschaftsgrund in Corneilles Illusion comique und Médée
Authors: Dickhaut Kirsten 
Published: December 2017

AbstractGhosts are omnipresent in Early Modern Theatre. Not only in Shakespeare but also in Corneille’s drama these apparitions serve to structure tragedies. The article discusses three functions of ghosts at the beginning of the 17th century: first, their technical aspect as a new form of a ‘deus ex machina’; second, their anthropological dimension as spirits, and third, their Christian equivalent as demons. Ghosts are used to decide the battle between good and evil or - as in Corneille’s Médée - between a king and a witch, that is between mystical and magical power systems. Whereas the king in this tragedy tries to strike the witch with a ban, Medea strikes back with the cunning technique of a ghost. By comparing techniques and functions of the use of ban and ghost, the article shows that Medea’s revenge is part of a duel between two powerful systems of magic and politics.
Fragmentary ancient languages as “bad data”
Authors: McDonald Katherine 
Published: December 2017

AbstractThe study of language contact in the ancient world has been an area of huge growth over the past ten years. However, in areas of the ancient world where sources are more limited, scholars have been more hesitant to make sweeping claims about the nature of language contact, even in communities where societal bilingualism is likely to have existed for many centuries. Languages only attested in fragmentary epigraphic corpora are considered the ultimate “bad data” and have not always received a great deal of attention in historical sociolinguistics, despite these texts representing our best evidence of many of the communities across the ancient Mediterranean. In response to this problem, this article asks how we should go about interpreting the evidence of ancient language contact in small or fragmentary corpora of texts. This article uses the Oscan corpus from Southern Italy (Lucania, Bruttium and Messina) c. 400-50 BCE as a case study for examining bilingualism in a fragmentary corpus. It outlines the data gathered from a range of different text-types from Southern Italy, the different kinds of contact phenomena which have been found in these texts, and whether there are any discernible patterns in the data. It argues, because of the fragmentary state of the Oscan corpus, that there is little clear evidence of chronological or geographic differentiation in levels of bilingualism. Rather, the evidence shows that in this corpus some text-types are more likely than others to contain contact phenomena. With this in mind, this paper proposes a new model which includes consideration of text-type for the interpretation of language contact and bilingualism in fragmentary corpora.
Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy
Authors: Srivastava Prashant K. , Roncon Paolo , Lukasiuk Katarzyna , Gorter Jan A. , Aronica Eleonora , Pitkänen Asla , Petretto Enrico , Johnson Michael R. , Simonato Michele 
Published: December 2017

AbstractThe identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis, and five differentially expressed in chronic epilepsy. Of these, 13 were not identified in any of the individual studies. To assess the role of these miRNAs, we predicted their mRNA targets and then filtered the list to include only target genes expressed in DG and negatively correlated with miRNA expression. Functional enrichment analysis of mRNA targets of miRNAs dysregulated during epileptogenesis suggested a role for molecular processes related to inflammation and synaptic function. Our results identify new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta-analysis in maximizing value from preclinical data.
The Local Coexistence Pattern of Selfing Genotypes in Caenorhabditis elegans Natural Metapopulations
Authors: Richaud Aurélien , Zhang Gaotian , Lee Daehan , Lee Junho , Félix Marie-Anne 
Published: December 2017

Abstract
To study the interplay of rare outcrossing and metapopulation structure, we focus on the nematode Caenorhabditis elegans. Its remarkably low outcrossing rate is at the extreme end of the spectrum for facultative selfing organisms. At the demographic level, C. elegans natural populations undergo boom and bust dynamics on ephemeral resources, with the dauer diapause larva acting as the dispersal form. Here we investigate the small-scale genetic structure of C. elegans populations in two localities over several years, using 2b restriction-associated DNA sequencing of nearly 1000 individuals. We find a remarkably small number of genome-wide haplotypes, almost exclusively in the homozygous state, confirming the low effective outcrossing rate. Most strikingly, the major haplotypes in a locality remain intact and do not effectively recombine over several years. From the spatial pattern of diversity, we estimate that each subpopulation or deme is seeded by a mean of 3–10 immigrating individuals. Populations are thus formed by clones that compete at two levels, within a subpopulation and at the metapopulation level. We test for the presence of local phenotypic variation in pathogen resistance and dauer larva nictation, which could possibly explain the maintenance of different genotypes by heterogeneous selection in different local environments or lifecycles. This study is the first to address the local spatiotemporal genetic structure of C. elegans on feeding substrates. We conclude that these animals coexist as competing homozygous clones at the smallest population scale as well as in the metapopulation.
The X-linked 1.688 Satellite in Drosophila melanogaster Promotes Specific Targeting by Painting of Fourth
Authors: Kim Maria , Ekhteraei-Tousi Samaneh , Lewerentz Jacob , Larsson Jan 
Published: December 2017

Abstract
Repetitive DNA, represented by transposons and satellite DNA, constitutes a large portion of eukaryotic genomes, being the major component of constitutive heterochromatin. There is a growing body of evidence that it regulates several nuclear functions including chromatin state and the proper functioning of centromeres and telomeres. The 1.688 satellite is one of the most abundant repetitive sequences in Drosophila melanogaster, with the longest array being located in the pericentromeric region of the X-chromosome. Short arrays of 1.688 repeats are widespread within the euchromatic part of the X-chromosome, and these arrays were recently suggested to assist in recognition of the X-chromosome by the dosage compensation male-specific lethal complex. We discovered that a short array of 1.688 satellite repeats is essential for recruitment of the protein POF to a previously described site on the X-chromosome (PoX2) and to various transgenic constructs. On an isolated target, i.e., an autosomic transgene consisting of a gene upstream of 1.688 satellite repeats, POF is recruited to the transgene in both males and females. The sequence of the satellite, as well as its length and position within the recruitment element, are the major determinants of targeting. Moreover, the 1.688 array promotes POF targeting to the roX1-proximal PoX1 site in trans. Finally, binding of POF to the 1.688-related satellite-enriched sequences is conserved in evolution. We hypothesize that the 1.688 satellite functioned in an ancient dosage compensation system involving POF targeting to the X-chromosome.
HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans
Authors: Agarwal Ipsita , Farnow Cassandra , Jiang Joshua , Kim Kyung-Sik , Leet Donna E , Solomon Ruth Z , Hale Valerie A , Goutte Caroline 
Published: December 2017

Abstract
Functionally redundant genes present a puzzle as to their evolutionary preservation, and offer an interesting opportunity for molecular specialization. In Caenorhabditis elegans, either one of two presenilin genes (sel-12 or hop-1) facilitate Notch activation, providing the catalytic subunit for the γ secretase proteolytic enzyme complex. For all known Notch signaling events, sel-12 can mediate Notch activation, so the conservation of hop-1 remains a mystery. Here, we uncover a novel “late-onset” germline Notch phenotype in which HOP-1-deficient worms fail to maintain proliferating germline stem cells during adulthood. Either SEL-12 or HOP-1 presenilin can impart sufficient Notch signaling for the establishment and expansion of the germline, but maintenance of an adult stem cell pool relies exclusively on HOP-1-mediated Notch signaling. We also show that HOP-1 is necessary for maximum fecundity and reproductive span. The low-fecundity phenotype of hop-1 mutants can be phenocopied by switching off glp-1/Notch function during the last stage of larval development. We propose that at the end of larval development, dual presenilin usage switches exclusively to HOP-1, perhaps offering opportunities for differential regulation of the germline during adulthood. Additional defects in oocyte size and production rate in hop-1 and glp-1 mutants indicate that the process of oogenesis is compromised when germline Notch signaling is switched off. We calculate that in wild-type adults, as much as 86% of cells derived from the stem cell pool function to support oogenesis. This work suggests that an important role for Notch signaling in the adult germline is to furnish a large and continuous supply of nurse cells to support the efficiency of oogenesis.
Die Kontrolle von Entgeltklauseln in Darlehensverträgen – eine Fortsetzungsgeschichte
Authors: Piekenbrock Andreas 
Published: December 2017

Zusammenfassung
Der für das Bankrecht zuständige XI. Zivilsenat des BGH hat die sog. Nobbe-Liste mit verdächtigen Entgeltklauseln der Kreditinstitute weiter abgearbeitet und nunmehr laufzeitunabhängige Bearbeitungsentgelte auch in unternehmerischen Darlehensverträgen für unbillig erklärt (§ 307 Abs. 1 BGB). Der Beitrag analysiert die bisherige Rechtsprechung kritisch und prüft Handlungsoptionen für die Zukunft.
Neue Möglichkeiten für Zahlungsdienstnutzer im Recht der Zahlungsdienste nach Umsetzung der PSD II
Authors: Werner Stefan 
Published: December 2017

Zusammenfassung
Durch die spätestens bis zum 13. 1. 2018 in nationales Recht umzusetzende Zweite EU-Zahlungsdiensterichtlinie (PSD II) wird das Recht der Zahlungsdienste nach Umsetzung der (Ersten) EU-Zahlungsdiensterichtlinie im BGB und Einführung des ZAG einer weiteren Überarbeitung unterzogen. Dabei wird auch eine Vielzahl an dem Verbraucher nützlichen zusätzlichen Regelungen eingeführt oder werden bestehende (überwiegend) zu seinen Gunsten modifiziert. Im Recht der Bundesrepublik Deutschland erfolgt dies durch das Gesetz zur Umsetzung der Zweiten Zahlungsdiensterichtlinie (ZDUG). Dieses Gesetz vom 17. 7. 2017, das am 21. 7. 2017 verkündet worden ist, wird die Anforderungen der PSD II daher fristgemäß in deutsches Recht umsetzen. Die in ihm enthaltenen Änderungen sollen im Weiteren unter dem Gesichtspunkt der Verbesserung der Position des Verbrauchers dargestellt werden. Die PSD II stärkt die Rechtsposition des Verbrauchers und führt neue Institute ein, die ihm zusätzliche Serviceleistungen zur Verfügung stellen.
Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor-Naïve Advanced Pancreatic Neuroendocrine Tumors
Authors: Salazar Ramon , Garcia-Carbonero Rocio , Libutti Steven K. , Hendifar Andrew E. , Custodio Ana , Guimbaud Rosine , Lombard-Bohas Catherine , Ricci Sergio , Klümpen Heinz-Josef , Capdevila Jaume , Reed Nicholas , Walenkamp Annemiek , Grande Enrique , Safina Sufiya , Meyer Tim , Kong Oliver , Salomon Herve , Tavorath Ranjana , Yao James C. 
Published: December 2017

Lessons Learned
Treatment with BEZ235 has not been shown to demonstrate increased efficacy compared with everolimus and may be associated with a poorer tolerability profile. The hypothesis of dual targeting of the phosphatidylinositol 3-kinase and mammalian target of rapamycin pathways in patients with advanced pancreatic neuroendocrine tumors may warrant further study using other agents.

Abstract: Background
This phase II study investigated whether targeting the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway via PI3K, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) inhibition using BEZ235 may be more effective than mTORC1 inhibition with everolimus in patients with advanced pancreatic neuroendocrine tumors (pNET) who are naïve to mTOR inhibitor therapy.

Methods
Patients with advanced pNET were randomized (1:1) to oral BEZ235 400 mg twice daily or oral everolimus 10 mg once daily on a continuous dosing schedule. The primary endpoint was progression-free survival (PFS). Secondary endpoints included safety, overall response rate (ORR), overall survival (OS), and time to treatment failure.

Results
Enrollment in this study was terminated early (62 enrolled of the 140 planned). The median PFS was 8.2 months (95% confidence interval [CI]: 5.3 to not evaluable [NE]) with BEZ235 versus 10.8 months (95% CI: 8.1–NE) with everolimus (hazard ratio 1.53; 95% CI: 0.72–3.25). The most commonly reported all-grade adverse events (&gt;50% of patients regardless of study treatment relationship) with BEZ235 were diarrhea (90.3%), stomatitis (74.2%), and nausea (54.8%).

Conclusion
BEZ235 treatment in mTOR inhibitor-naïve patients with advanced pNET did not demonstrate increased efficacy compared with everolimus and may be associated with a poorer tolerability profile.
ESPECIALISTAS DO BRASIL E DO EXTERIOR FAZEM DE FLORIANÓPOLIS A CAPITAL DO SANEAMENTO POR DOIS DIAS
Authors: Gallina Valter José 
Published: December 2017

Durante dois dias, o Congresso Catarinense de Saneamento e o Encontro Técnico da Casan transformaram Florianópolis na Capital Brasileira do Saneamento. O tema aparentemente complexo, geralmente de pouca atenção da população brasileira, integrou em 31 de agosto e 1º de setembro de 2017 mais de 2.500 pessoas, numa demonstração de que Santa Catarina está disposta a reverter o passivo no setor. Ficou no passado o tempo em que saneamento era um assunto que ninguém queria falar.
OS IMPACTOS DAS ATIVIDADES TURÍSTICAS, RECREATIVAS E ESPORTIVAS NA BACIA HIDROGRÁFICA DO RIO DAS ANTAS, BACIAS CONTÍGUAS E AFLUENTES DO RIO PEPERI-GUAÇU
Authors: Fermino Fernanda Bonato , Fermino Gean Carlos , Rhoden Anderson Clayton 
Published: December 2017

A gestão de recursos hídricos está relacionada às políticas públicas, práticas, tecnologias aplicadas na distribuição, uso e conservação da água. O alto custo ambiental resultante da má gestão dos recursos passou a exigir de todos os setores uma rigorosa regulação de atividades e mitigação dos impactos por elas causados. Os impactos negativos aos recursos hídricos geram danos irreversíveis, graves conflitos, sendo a solução nestes casos lenta, extensa e demandando altos investimentos. Neste cenário, a demanda do turismo, lazer e esporte figuram de forma complementar, entretanto, se as áreas forem observadas pela perspectiva ambiental, estas atividades se tornam representativas, pois são impactadas pelos demais problemas oriundos dos outros setores. Do método, através de levantamento bibliográfico, pesquisa primária, secundária, exploratória, saídas de campo in loco e busca quali e quantitativa, este estudo de caso identificou os usos dos recursos hídricos em 35 municípios que compõem a Bacia Hidrográfica do Rio das Antas, bacias contíguas e afluentes do Rio Peperi-Guaçu / Região Hidrográfica 01, no Oeste de Santa Catarina, observou suas potencialidades turísticas, esportivas, recreativas e culturais, avaliou os impactos de cada atividade. Estas sofrem diretamente com escassez e com a falta de qualidade dos recursos hídricos. Ainda que neste estudo de caso os resultados representem baixos impactos aos recursos hídricos por conta do baixo grau de desenvolvimento turístico da região, as atividades devem observar e mensurar seus impactos atuais, a fim mitigar os impactos ambientais, reduzir conflitos dos usos múltiplos das águas, elaborar o planejamento e ações efetivas de desenvolvimento sustentável.