bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balancing Act: A Qualitative Study on the Dual Nature of Video Game Addiction among medical college students in Chengalpattu district, Tamil Nadu
Authors: Sushmitha G , Eashwar V.M Anantha , Charulatha R. J. , Surya B.N 
Published: September 2024

Abstract

Introduction:
Video games have recently become a significant field that has grown and transformed how people engage with themselves and others. This study aims to understand the motives, needs, and concerns of gamers addicted to video games and to explore the self-perceived impact of video games on college students' social, personal, and academic lives.
Materials and Methods
This was a comprehensive qualitative study conducted among medical students in the Chengalpattu district of South India. We used a semi-structured questionnaire guide to collect data from medical students identified as problem gamers according to the Internet Gaming Disorder Scale-Short Form (IGDS9-SF) questionnaire. Data was meticulously collected through in-depth interviews and transcribed verbatim. We ensured the reliability of our findings by reaching data saturation after interviewing 25 study participants. Qualitative data were analysed using deductive content analysis with the aid of Qualcoder Software.
Result
The primary themes that emerged from the study highlighted that individuals often use video games as a coping strategy to alleviate stress related to personal and academic pressures and to foster social connections. The benefits reported by participants included mood improvement and enhanced decision-making abilities. On the downside, the negative impacts identified were insufficient sleep, musculoskeletal problems, and impulsive gaming behaviour.
Conclusion
Video games serve as an efficient coping strategy for managing stress and social engagement, offering various benefits such as mood enhancement and improvement in the skills related to decision-making. However, these are overshadowed by drawbacks such as inadequate sleep, musculoskeletal problems and impulsive gaming behaviour.
Molecular analysis of spinal nerve sheath tumors has identified CSH1 as a candidate gene for differentiating between Schwannomatosis and Spinal schwannoma
Authors: Shi Guosheng , Ren Huiling , Zhao Dawei , Zhao Qinglin , Chen Hequn , Luo Xuanbo , Zhao Jingnan , Yan Suwei , Bu Wei 
Published: September 2024

Abstract

Purpose
The most common form of schwannomatosis is characterized by multiple and recurrent spinal schwannomas, exhibiting symptoms similar to those of spinal schwannomas. The molecular factors responsible for tumor multiplicity in schwannomatosis are not yet understood. This study aims to identify differentially expressed genes (DEGs) between intradural spinal schwannomas and schwannomatosis, and explore the underlying mechanisms of schwannomatosis pathogenesis
Methods
We used high-throughput sequencing technology to sequence 30 tumor samples(15 conventional spinal schwannomas and 15 schwannomatosis cases), and identified DEGs between the two sample groups using the limma R package. Using machine learning algorithms to identify more significant biomarkers from the DEGs.We evaluated the diagnostic value of these biomarkers for schwannomatosis using receiver operating characteristic (ROC) curve analysis and an Alignment Diagram. Gene set enrichment analysis (GSEA) was employed to explore relevant pathways.
Result
Our findings revealed 249 DEGs, with OXTR, CSH1, SNCAIP, and DPP4 emerging as candidate genes.Subsequent q-PCR experiments validated these biomarkers' reliability. Validation showed that CSH1 expression was elevated in schwannomatosis samples, while DPP4, OXTR, and SNCAIP expressions were decreased compared to solitary schwannoma cells. ROC curves and the Alignment Diagram confirmed the stability and accuracy of our diagnostic model.GO functional annotation and KEGG pathway enrichment analysis indicated that these DEGs might be involved in biological activities related to immunity, inflammation regulation, and tumorigenesis.
Conclusion
We have developed a novel diagnostic model for distinguishing between schwannomatosis and spinal schwannomas. Moreover,These transcriptional changes enhance our understanding of the pathogenesis of schwannomatosis, identify risk factors, and provide insights into new therapeutic targets.
Late Onset of Biliobronchial Fistula — A Serious Complication of Hemihepatectomy for Atrophic Liver with Hepatolithiasis: A Case Report and Review of the Literature
Authors: Yan Chen-Ze , Jia Zhong , Wan Ya-Feng , Zhou He-Shan 
Published: September 2024

Abstract

Background: Acquired bronchobiliary fistula (BBF) is a rare but life-threatening complication that can occur as a result of oncological processes, inflammatory reactions, parasite infections, thoracoabdominal trauma, or invasive procedures associated with iatrogenic injury. However, the potential etiology of BBF caused by surgical device-derived diathermy burn and its post-burn effects has never been reported.
Case presentation: Herein, we present a case of a 65-year-old woman who developed BBF one month after hepatectomy and presented with refractory irritating cough accompanied by yellow bitter sputum. The diagnosis was confirmed through detection of bile components in the sputum, fiberoptic bronchoscopy examination, andendoscopic retrograde cholangio-pancreatography (ERCP) . Unfortunately, both endobronchial blocker and endoscopic nasobiliary drainage(ENBD) failed to address the condition until surgical removal of the involved subdiaphragmatic fistula followed by pedicled greater omentum tamping were performed. After closure of the fistula during a 5-month follow-up period, she did not experience any further episodes of biloptysis.
Conclusions: For diathermy burn associated BBF , non-surgical management proves difficult due to inadequate or ineffective biliary drainage, so that early surgical intervention should be considered as an effective approach.
Validation Study of the Doctor's Endoscopy Chair and Endoscope Carrying/Manipulation Apparatus
Authors: Toksoz Serdar , Asik Alper , Kizilkan Yalcin , Senel Samet , Sarica Kemal 
Published: September 2024

Abstract

This study aimed to validate the functionality and usability of the doctor's endoscopy chair and endoscope carrying/manipulation apparatus known as EasyFlex. Prototype models of the EasyFlex apparatus were evaluated by five expert urologists specializing in endourology at three different medical centers: Hatay Training and Research Hospital, Ankara Bilkent City Hospital, and Sancaktepe Sehit Prof. Dr. Ilhan Varank Research and Training Hospital. During the evaluation, the surgical and ergonomic benefits of the doctor's endoscopy chair and endoscope carrying/manipulation apparatus were compared with those used during the traditional flexible ureterorenoscopy (fURS) procedures in the management of kidney stones. Evaluation of both systems from ergonomic aspect showed that traditional flexible ureterorenoscopy procedures had significantly higher overall ergonomic efficiency scores than the EasyFlex apparatus, as reported by all participating surgeons (p < 0.001). Additionally, traditional fURS had significantly higher ergonomic scores than EasyFlex (37.6 vs. 12.6, (p < 0.001). Furthermore, the EasyFlex fURS group had significantly lower intraoperative complication rates than the traditional fURS group (11.8% vs. 27%, p = 0.017). When compared with traditional approach, results obtained in our study demonstrated well that EasyFlex apparatus could provide superior ergonomic conditions during fURS procedures. Additionally, the rate of intraoperative complications EasyFlex system has been found to be limited compared to traditional approach.
Prevalence of Dry Eye Disease, Associated Factors and Impact on Quality of Life among Medical Students during the Covid-19 pandemic
Authors: Kunboon Attapinya , Tananuvat Napaporn , Uphapong Phit , Wongpakaran Nahathai , Wongpakaran Tinakon 
Published: September 2024

Abstract

This cross-sectional study aimed to evaluate the prevalence of dry eye disease (DED), its associated factors, and the impact on quality of life (QOL) and mental health among medical students during the COVID-19 era using online surveys. Participants completed questionnaires covering demography, medical history, and personal data. The Thai version of the Dry Eye-related Quality of Life Score (DEQS-Th) was used for DED screening. The QOL and mental health challenges (support, coping, stress, and depression) were evaluated by the EuroQoL-5 dimensions-5 levels (EQ-5D-5L) and Thymometer questionnaires. A total of 449 participants were analyzed, with a mean age of 21.8 years and 61.5% female. The prevalence of DED was 60.4% (95%CI 55.7–64.8). Preexisting DED (p = 0.001) and refractive errors (p = 0.007) were significantly associated with DED. The DEQS-Th score, the EQ-5D-5L score, and all aspects of mental health challenges were significantly worse in DED participants compared to non-DED participants. The DEQS-Th score was significantly correlated with the EQ-5D-5L index score and all issues of mental health challenges, though these correlations were not strong (r = 0.094 to 0.337, all p < 0.05). This study highlighted the high prevalence of DED among medical students during the pandemic and its negative impact on QoL and mental health.
Retroperitoneal angiomatoid fibrous histiocytoma: two cases of rare adult disease and a literature review
Authors: Li Min , Xia Zhenyuan , Yu Xiaoping , Luo Nifei , Xu Guanglong , Zhao Fanyu 
Published: September 2024

Abstract

Background
Angiomatoid fibrous histiocytoma (AFH) is a rare and potentially low-grade malignant soft tissue tumor, more commonly found in children and young adults. It typically arises in the deep dermis and subcutaneous tissues of the limbs, followed by the trunk and head/neck regions. Retroperitoneal AFH is exceedingly rare, with local recurrence and metastasis even rarer occurrences.
Case presentation
This report presents clinical, imaging, biopsy, and molecular detection results from two cases of adult retroperitoneal AFH. One case experienced recurrence and metastasis one year post-surgery. Additionally, this article integrates these cases with a literature review of published instances of retroperitoneal AFH.
Conclusions
Retroperitoneal AFH is uncommon; patients with incomplete tumor capsules and surrounding invasion are predisposed to postoperative recurrence and metastasis. A definitive diagnosis relies on pathology. By detailing these two cases of retroperitoneal AFH, we aim to enhance medical professionals' understanding of this disease.
StressFit: A Hybrid Wearable Physicochemical Sensor Suite for Simultaneously Measuring Electromyogram and Sweat Cortisol
Authors: Hossain Nafize Ishtiaque , Noushin Tanzila , Tabassum Shawana 
Published: September 2024

Abstract

This study introduces StressFit, a novel hybrid wearable sensor system designed to simultaneously monitor electromyogram (EMG) signals and sweat cortisol levels. Our approach involves the development of a noninvasive skin patch capable of monitoring skin temperature, sweat pH, cortisol levels, and corresponding EMG signals using a combination of physical and electrochemical sensors integrated with EMG electrodes. StressFit was optimized by enhancing sensor output and mechanical resilience for practical application on curved body surfaces, ensuring accurate acquisition of cortisol, pH, body temperature, and EMG data without sensor interference. In addition, we integrated an onboard data processing unit with Internet of Things (IoT) capabilities for real-time acquisition, processing, and wireless transmission of sensor measurements. Sweat cortisol and EMG signals were measured during cycling exercises to evaluate the sensor suite’s performance. Our results demonstrate an increase in sweat cortisol levels and decrease in the EMG signal’s power spectral density following exercise. These findings suggest that combining sweat cortisol levels with EMG signals in real-time could serve as valuable indicators for stress assessment and early detection of abnormal physiological changes.
Real-world clinical features and survival outcomes in diffuse large B-cell lymphoma patients with hepatitis B virus infection
Authors: Yang Wanxi , Zhao Xue , Ma Hongbing , Xu Caigang 
Published: September 2024

Abstract

Objective
Hepatitis B virus (HBV) infection is associated with the incidence and prognosis of diffuse large B-cell lymphoma (DLBCL), and previous studies differ in terms of clinical characteristics and prognostic factors. In this study, we explored the clinical features and prognostic characteristics of real-world DLBCL patients infected with HBV.
Methods
Patients with pathologically diagnosed primary DLBCL at West China Hospital of Sichuan University were enrolled. Patients with follicular lymphoma-transformed DLBCL, primary central nervous system DLBCL, and hepatitis C virus (HCV), hepatitis E virus (HEV), human immunodeficiency virus (HIV), or syphilis (TP) infections were excluded. Ultimately, a total of 941 patients were included in this study. All patients included in the study underwent HBV serum marker testing before treatment. The demographic features, clinical characteristics and treatments of patients with different HBV infection states were collected and analyzed comprehensively to identify prognostic factors for OS and PFS.
Results
Statistical analysis of the data revealed that hepatitis B surface antigen-positive (HBsAg+) DLBCL patients were younger, had more advanced disease at diagnosis, had a greater proportion of germinal center B cell-like lymphoma (GCB) type disease, and had more frequent B symptoms and splenic involvement. There were no significant differences in OS or PFS among patients with different HBV infection statuses χ2 = 0.139, P = 0.933; χ2 = 0.787, P = 0.675); HBsAg + DLBCL patients treated with the R-CHOP/R-CHOP-like regimen had better OS and PFS (χ2 = 7.679, P = 0.006; χ2 = 9.042, P = 0.003); antiviral prophylaxis for HBsAg + DLBCL patients improved OS and PFS (HR: 0.336, P = 0.012, 95% CI [0.143, 0.788]; HR: 0.740, P = 0.032, 95% CI [0.171, 0.925]), and tenofovir improved OS and PFS (χ2 = 4.644, P = 0.031; χ2 = 4.554, P = 0.033).
Conclusions
HBsAg + DLBCL patients have unique clinical characteristics, and the use of CD20 monoclonal antibody based regimens significantly improves the outcome and prognosis of patients with HBsAg + DLBCL; anti-HBV therapy, especially tenofovir, improves the prognosis of patients with DLBCL associated with HBV-presenting infection.
Structural Characterization and Application of Crosslinked Soybean Protein Isolate-Based Oleogel Containing κ-Carrageenan: A Promising Approach for Surimi Product Development
Authors: Yang Xiaoqing , Tan Zhifeng , Wang Zheming , Yu Xiliang , Wang Qi , Yu Chenxu , Dong Xiuping 
Published: September 2024

Abstract

In this study, Soybean Isolate Protein (SPI) based oleogel was constructed by mixing SPI and κ-Carrageenan (κ-CG) using an emulsion-template approach optimized by adjusting SPI/κ-CG ratio. The results demonstrated that the intramolecular and intermolecular hydrogen-bonds between SPI and κ-CG reinforced three-dimensional lattice structure of the oleogels. With the increase of κ-CG content, the oil droplets were more uniformly dispersed in the continuous SPI-κ-CG rigid network, which formed a dense network structure and improved the storage module, loss module, recovery rate, and gel strength of the resulting oleogels. In particular, when the SPI/κ-CG ratio was 9/1, the oleogel was dense and delicate with no oil leakage. This formulation also showed the highest oil binding capacity (OBC, 94.52%) and thermal stability (412.91 ℃). Cryo-scanning electron microscopy showed that the oleo-surimi gel had a dense network structure, and the oil droplets were stably encapsulated in the surimi gel matrix by polysaccharide-protein interfacial membrane. Compared with surimi gel made with the direct addition of liquid oil, the water-holding capacity and textural properties of oleo-surimi gel were effectively improved. The approach of making oleo-surimi gel could lead to innovation in the development of novel surimi products.
OREVI_PCH: An Optimized Resource-Efficient Redaction Mechanism with Integrity Validation in Policy-based Chameleon Hash for IoT Applications
Authors: Ali Shams Mhmood Abd , Yusoff Mohd Najwadi , Teh Je Sen , Hasan Hasan Falah 
Published: September 2024

Abstract

Blockchain technology’s decentralized paradigm can enhance the day-to-day operations of industries, including those driven by the Internet of Things (IoT). Blockchain’s immutability is a crucial feature to prevent unauthorized amendment of data. However, the misuse of this feature hinders the adoption of blockchain in the IoT space. Therefore, we need balanced data redaction solutions that will not compromise immutability, specifically in resource-constrained environments. Existing solutions such as the policy-based chameleon hash (PCH) functions offer fine-grained access control over transaction-level redaction but are computationally intensive. Additionally, transaction owners are assumed to be honest, relying entirely on the permissioned blockchain without verifying their credibility. This paper proposes an optimized resource-efficient redaction mechanism with integrity validation in PCH (OREVI_PCH), a construction for blockchain data redaction that has reduced computational requirements. A noninteractive zero-knowledge (NIZK) proof based on the Fiat-Shamir transform is adopted to validate the honest behavior of data owners. The formal definition, concrete construction, and security analysis show that OREVI_PCH achieves complete indistinguishability and insider collision resistance. Performance comparisons between OREVI_PCH and PCH demonstrate improved computational and storage costs. Our findings also show that OREVI_PCH outperforms the current state-of-the-art solutions in terms of initialization, hashing, and adaptation overheads. While OREVI_PCH’s behavior validation mechanism introduces additional overhead, this is reasonable considering behavior validation has not been accounted for in the design of existing schemes. OREVI_PCH also supports more transactions per second, making it better suited for time-sensitive applications.
LumaCam: A Novel Class of Position-Sensitive Event Mode Particle Detectors using Scintillator Screens
Authors: Wolfertz Alexander , Gustschin Alex , Schulz Michael , M. Alexander M. Alexander , Khaplanov Anton , Hirsh Tsviki Y. , Nomerotski Andrei , Morgano Manuel , Tremsin Anton , Mauri Giacomo , Sykora G. Jeff , Losko Adrian 
Published: September 2024

Abstract

A new type of position-sensitive detectors is gaining attention in the neutron community. They are scintillator based detectors that detect the scintillation light on an individual photon basis via an image intensifier and a fast image sensor. Their readout operates in event mode i.e. it produces information about individual neutron interactions, reconstructed from the sensor data, thus enabling to achieve superior spatial and temporal resolutions compared to regular detectors. Although the development of current detectors is focused on neutrons, the concept is also applicable to the detection of other particles such as high-energy photons. This document provides a description on how these detectors are built, how they operate, and what their characteristics are. An example of a detector implementation based on a Timepix3 chip is described to illustrate the detector concept. This includes a detailed description of the event reconstruction algorithm, one of the core components that sets it apart from established detectors. Energy-resolved epithermal neutron radiography was performed at the ISIS EMMA beamline with this detector, illustrating some of the fundamental differences in the data that can be produced with the new type of detector compared to more established types of scintillator based neutron detectors. The term LumaCam is proposed to refer to this new class of position-sensitive event-mode detectors.
Evaluation of wheatstraw, sawdust, banana fronds, maize cobs and cotton hulls substrate combinations for Pleurotus ostreatus cultivation.
Authors: Elyson Silivani , Jonathan ChisangoTawanda , Kudakwashe Chitindingu , Loice ChiguNomathemba 
Published: September 2024

Abstract

The yield and quality of oyster mushroom is largely dependent on the chemical and nutritional content of the substrate. The objective of the study was to determine the effect of different individual substrates and substrate combinations on the perfomance of P.ostreatus for growth and sustainable development of the mushroom cultivation industry in Zimbabwe. Various individual substrates used as treatments, selected for the cultivation of oyster mushrooms were, wheatstraw, cotton hulls, sawdust, maize cobs and banana fronds each of 1kg and replicated 4 times. Various substrate combinations, also used as treatments were, cotton hulls and wheatstraw, cotton hulls and sawdust, cotton hulls and maizecobs, cotton hulls and banana fronds in the ratio 1:1. Each combination weighed 1kg and was replicated 4 times.Compound substrates perfomed much better in terms of biological efficiency and spawn run compared to individual substrates. The highest biological efficiency (76%) and spawn run(17 days) were obtained from combining cotton hulls and sawdust. Spawn run was fastest(12 days) for cotton hulls and wheatstraw combination. Analysis in terms of economic return, revealed that mushroom production was most profitable using cotton hulls and sawdust as substrate with a benefit-cost ratio of 5.7 compared to other combinations of agricultural residues. In terms of spawn run, yield and economic return, combining cotton hulls and sawdust is highly recommended for farmers involved in the cultivation of Pleurotus ostreatus to satisfy increasing consumer demand, whilst decreasing pressure on limited natural resources and preventing ecosystems degradation.
Human-Robot Cooperative Object Transportation with Intention-Driven Manipulation and Trajectory Guidance
Authors: He Xinjie , Gao Qing , Tian Xinyang , Yu Xiaolong 
Published: September 2024

Abstract

This paper addresses the problem of human-robot cooperative object transportation, taking into account human intervention while tracking the desired trajectory. To solve this problem, an object dynamic model during the human-robot transportation is firstly conducted. Then a PID controller is implemented to track the desired contact force and human's position, while other dimensions was moved by a zero-stiffness admittance control framework to facilitate human manipulation. To enhance real-time trajectory correction, a model-predictive controller (MPC) is employed to guide the human to follow the reference trajectory. Meanwhile, an acceleration adjusting factor is designed to switch the motion mode between active interaction and trajectory tracking. Finally, the performance of the proposed approach is verified by a set of experiments under loaded and unloaded transportation conditions.