bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double-loop importance sampling for McKean–Vlasov stochastic differential equation
Authors: Ben Rached Nadhir , Haji-Ali Abdul-Lateef , Subbiah Pillai Shyam Mohan , Tempone Raúl 
Published: October 2024

AbstractThis paper investigates Monte Carlo (MC) methods to estimate probabilities of rare events associated with the solution to the d-dimensional McKean–Vlasov stochastic differential equation (MV-SDE). MV-SDEs are usually approximated using a stochastic interacting P-particle system, which is a set of P coupled d-dimensional stochastic differential equations (SDEs). Importance sampling (IS) is a common technique for reducing high relative variance of MC estimators of rare-event probabilities. We first derive a zero-variance IS change of measure for the quantity of interest by using stochastic optimal control theory. However, when this change of measure is applied to stochastic particle systems, it yields a $$P \times d$$

P
×
d

-dimensional partial differential control equation (PDE), which is computationally expensive to solve. To address this issue, we use the decoupling approach introduced in (dos Reis et al. 2023), generating a d-dimensional control PDE for a zero-variance estimator of the decoupled SDE. Based on this approach, we develop a computationally efficient double loop MC (DLMC) estimator. We conduct a comprehensive numerical error and work analysis of the DLMC estimator. As a result, we show optimal complexity of $$\mathcal {O}\left( \textrm{TOL}_{\textrm{r}}^{-4}\right) $$

O

TOL

r

-
4

with a significantly reduced constant to achieve a prescribed relative error tolerance $$\textrm{TOL}_{\textrm{r}}$$

TOL
r

. Subsequently, we propose an adaptive DLMC method combined with IS to numerically estimate rare-event probabilities, substantially reducing relative variance and computational runtimes required to achieve a given $$\textrm{TOL}_{\textrm{r}}$$

TOL
r

compared with standard MC estimators in the absence of IS. Numerical experiments are performed on the Kuramoto model from statistical physics.
Impact of vegetation coverage and configuration on urban temperatures: a comparative study of 31 provincial capital cities in China
Authors: Wang Chengcong , Ren Zhibin , Zhang Peng , Guo Yujie , Hong Shengyang , Hong Wenhai , Wang Xinyu , Geng Ruoxuan , Meng Fanyue 
Published: October 2024

AbstractUrban vegetation plays a crucial role in regulating temperatures and heat waves in urban areas. However, the influence of vegetation coverage and its configuration on surface temperatures in different climate zones at a national scale is unclear. To address this, we utilized high-resolution data to detect spatial patterns for 31 provincial capital cities in China. We integrated day and night surface temperatures to determine the influence of vegetative coverage and configuration on urban temperatures across different climate zones and city sizes. Our study revealed that a subtropical monsoon climate and medium-sized cities had the highest vegetative coverage and shape complexity. The best connectivity and agglomeration of vegetation were found in a temperate monsoon climate and large cities. In contrast, small cities, especially those under a temperate continental climate, had low vegetation coverage, high fragmentation, and weak agglomeration and connectivity. In addition, vegetative coverage had a negative impact on daytime surface temperatures, especially in large cities in a subtropical monsoon climate. However, an increase in vegetation coverage could result in warming at night in small cities in temperate continental climates. Although urban vegetation configuration also contributed to moderating surface temperatures, especially at night, they did not surpass the influence of vegetation coverage. The effect on nighttime temperatures of the configuration of vegetation increased by 3–6% relative to that of daytime temperatures, especially in large cities in a temperate monsoon climate. The contribution vegetation coverage and configuration interaction to cooling efficiency decreased at night, especially in medium-sized cities in a temperate continental climate by 3–5%. In addition, this study identified several moderating effects of natural and social factors on the relationship between urban vegetation coverage and surface temperatures. High duration of sunshine, low humidity and high wind speed significantly enhanced the negative impact of vegetation coverage on surface temperatures. In addition, the moderating effect of vegetation coverage was more pronounced in low population density cities and high gross domestic product. This study enhances understanding of the ecological functions of urban vegetation and provides a valuable scientific basis and strategic recommendations for optimizing urban vegetation and improving urban environmental quality.
Assessing Military Mental Health during the Pandemic: A Five Country Collaboration
Authors: Lee Jennifer E. C. , Bennett Clare , Bennett Neanne , Bouak Fethi , Goldenberg Irina , Harrison Kate , Edge Heather McCuaig , Bell Amy Millikan , Quartana Phillip J. , Simms Maj Amos , Adler Amy B. 
Published: October 2024

Abstract
Purpose of Review
Members of a technical panel representing Australia, Canada, New Zealand, the UK, and the US collaborated to develop surveys designed to provide military leaders with information to guide decisions early in the COVID-19 pandemic. The goal of this paper is to provide an overview of this collaboration and a review of findings from the resulting body of work.

Recent Findings
While surveys pointed to relatively favorable mental health and perceptions of leadership among military personnel early in the pandemic, these observations did not reflect the experiences of personnel deployed in COVID-19 response operations, nor were these observations reflective of later stages of the pandemic.

Summary
Establishing and leveraging networks that enable the rapid development of employee surveys and sharing of results can serve as a pathway for empowering military leaders in times of crisis. Organizational support and leadership decisions are especially critical for maintaining well-being among personnel during crises.
Distinguishing 2-knots admitting circle actions by fundamental groups
Authors: Fukuda Mizuki , Ishikawa Masaharu 
Published: October 2024

AbstractA 2-sphere embedded in the 4-sphere invariant under a circle action is called a branched twist spin. A branched twist spin is constructed from a 1-knot in the 3-sphere and a pair of coprime integers uniquely. In this paper, we study, for each pair of coprime integers, if two different 1-knots yield the same branched twist spin, and prove that such a pair of 1-knots does not exist in most cases. Fundamental groups of 3-orbifolds of cyclic type are obtained as quotient groups of the fundamental groups of the complements of branched twist spins. We use these groups for distinguishing branched twist spins.
Effects of traditional Chinese medicine on outcomes and costs of dementia care: results from a retrospective real-world study
Authors: Weng Yi-Xiang , Yang Chien-Chung , Hsu Wen-Chuin , Kuo Raymond N. 
Published: October 2024

Abstract
Objectives
This study aims to assess the impact of Traditional Chinese Medicine (TCM) on dementia patients, utilizing real-world data. Specifically, it seeks to evaluate how TCM influences clinical outcomes by examining changes in the Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) scores, as well as its effect on medical expenses over a two-year period. Data from a multi-center research database spanning from 2004 to 2021 will be used to achieve these objectives, addressing the current gap in empirical data concerning intuitive outcomes and cognitive function assessments.

Methods
Propensity score matching was adopted to improve comparability among the intervention and control groups. Due to repeated dependent variable measurements, the generalized estimating equation was used to control for socio-demographic characteristics, regional characteristics, and Western medicine treatments for dementia.

Results
After propensity score matching, a total of 441 research subjects were included: 90 in the TCM intervention group and 351 in the non-TCM intervention group. The results of multivariate regression analysis showed that compared with the non-TCM intervention group, the MMSE scores in the TCM intervention group increased by 0.608 points each year. The annual change in CDR scores in the TCM intervention group was 0.702 times that of the non-TCM utilization group. After TCM intervention, annual outpatient expenses increased by US$492.2, hospitalization expenses increased by US$324.3, and total medical expenses increased by US$815.9, compared with the non-intervention group.

Conclusions
TCM interventions significantly decelerate cognitive decline in dementia patients, evidenced by slower reductions in MMSE scores and mitigated increases in CDR scores. However, these benefits are accompanied by increased medical expenses, particularly for outpatient care. Future healthcare strategies should balance the cognitive benefits of TCM with its economic impact, advocating for its inclusion in dementia care protocols.
Practice and reflections on regional mutual recognition of clinical research ethics review——based on survey results from medical and health institutions in Jiangsu Province
Authors: Liu Xiaolin , Hong Qian , Huang Jingzhi , Zhu Hongsen , Zhao Qing , Bao Jun 
Published: October 2024

AbstractWith the continuous advancement of medical research, the number of multi-center clinical studies has been steadily increasing, bringing about significant challenges to ethical review. Improving the efficiency and quality of ethical review has become a necessity driven by national policies and the development of the industry. Mutual recognition of ethical reviews is one of the most effective ways to enhance the efficiency of ethical review in multi-center clinical trials. The promotion of mutual recognition of ethical reviews is both feasible and practically significant; however, progress has been less than ideal. Through conducting surveys, this study attempts to understand the status of mutual recognition of ethical reviews in Jiangsu Province, identify the reasons hindering the implementation of mutual recognition, and propose possible solutions. The results indicate that while most medical and health institutions are aware of the policies related to mutual recognition of ethical reviews, the majority remain in a wait-and-see attitude. Ensuring policy guarantees and the high quality and homogeneity of ethical review across institutions are considered necessary conditions for achieving mutual recognition of ethical reviews.
Zircon Xenocrysts From Easter Island (Rapa Nui) Reveal Hotspot Activity Since the Middle Jurassic
Authors: Rojas‐Agramonte Yamirka , Pardo Natalia , van Hinsbergen Douwe J. J. , Winter Christian , Marroquín‐Gómez María Paula , Liu Shoujie , Gerdes Axel , Albert Richard , Wu Shitou , García‐Casco Antonio 
Published: October 2024

AbstractWe report the finding of mantle‐derived zircon grains retrieved from red soils, regoliths, and beach sands from Easter Island, that are much older than the island volcanism (0–2.5 Ma) and its underlying lithosphere (Pliocene, 3–4.8 Ma). A large population of 0–165 Ma old zircons have coherent oxygen (δ18O 3.8–5.9‰) and hafnium (εHf(t)+3.5–+12.5) mantle isotopic signatures. These results are consistent with the crystallization of zircon from plume‐related melts. In addition, a chemically diverse population with ages from the Paleozoic to the Archean was found. These older populations are enigmatic but they could represent remnants of ancient subducted sediments. Meanwhile, the ∼0–165 Ma population is interpreted as plume‐derived, suggesting that the hotspot started at least ∼165 Ma ago. A spike of ∼164–160 Ma zircons could represent a Large Igneous Province (LIP) stage upon the first arrival of the plume. We use plate reconstructions to show that such a LIP would have formed on the Phoenix Plate and would have subducted below the Antarctic Peninsula around 100–105 Ma. There, LIP subduction would offer a solution for the enigmatic Palmer Land deformation event, previously proposed to result from a collision with an unknown indenter. The here‐reported “ghost” of a prolonged hotspot activity suggests that fragments of the Easter plume and of the ambient sub‐lithospheric mantle stored and re‐sampled zircon xenocrysts due to convective (re)circulation at the scale of the plume head. Our study demonstrates how zircon geochronology and geochemistry provide novel insights into global‐scale geodynamics, offering new perspectives on the dynamics of mantle plumes and hotspot activity.
¿Libre de la Maleza Estatista? Assessing Neoliberal Promises and Water Markets in Chile
Authors: Reade Malagueño Benji , D'Odorico Paolo 
Published: October 2024

AbstractNeoliberal approaches to water governance, pioneered in Chile in the 1980s, are reappearing today on the centerstage of the water policy debate. While advocates claim that strong property rights, limits on government authority, and water markets can enhance environmental sustainability, efficiency, neutrality, and equity in the distribution of water rights, limited empirical evidence exists on whether neoliberal policies have delivered on these key promises. In this paper, we combine hydrological analysis with a nationwide data set on government water rights allocations between 1981 and 2021 to determine when and where water has been allocated beyond sustainable limits. We then integrate water market transaction and agricultural data to assess how allocations and scarcity conditions relate to spatial and temporal patterns in irrigation, crop distribution, and water market activity. Our results indicate that 30% of catchments are overallocated, and that continued government allocations of water rights during scarcity exacerbate already‐high inequalities in the distribution of water. We find no evidence that scarcity or water markets induced improvements in numerous efficiency metrics. Overall, our results support growing claims that the neoliberal water model fails to fulfill its key promises, notably to the detriment of nature and marginalized rural communities.
Revealing Inconsistencies in ROTI Index Using Multi‐GNSS Constellation Measurements: Impact of Sampling Rates and Time Window
Authors: Sui Yi , Yang Zhe , Zhan Weijia 
Published: October 2024

AbstractUnderstanding ionospheric irregularities and their dynamics is crucial, with the rate of change of the total electron content index (ROTI) serving as a significant metric for this purpose. However, inconsistencies in ROTI magnitudes have been noted when sampled at one‐second interval across various Global Navigation Satellite System (GNSS) receivers. This study presents a detailed statistical analysis to investigate inconsistencies in ROTI using multi‐GNSS observations in conjunction with four distinct GNSS receiver types. Various factors affecting the ROTI inconsistencies among receivers were examined, including differences in sampling rates (1, 5, 15, and 30 s), and varying time window widths (1, 2, and 5 min). By examination of data obtained from GNSS receivers with zero or short baselines on a global scale, the analysis uncovered substantial variations in multi‐GNSS ROTI values across the four assessed receiver types. The main findings suggest that reducing the sampling rate reduces the inconsistencies in the magnitude of ROTI, particularly at lower sampling rates. This reduction can be attributed to the exclusion of high‐frequency components in the ROTI spectrum. Interestingly, the width of the time window is found to have minimal impact on the ROTI magnitude. The study also shows a direct correlation between a larger magnitude of ROTI and the increased noise in the signals tracked by receivers. These results emphasize the importance of considering sampling rates and GNSS receiver types when utilizing ROTI to investigate ionospheric irregularities.
Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker
Authors: Kario Kazuomi , Ohbayashi Hiroyuki , Hashimoto Masami , Itabashi Naoki , Kato Mitsutoshi , Uchiyama Kazuaki , Hirano Kunio , Nakamura Noriko , Miyamoto Takahide , Nagashima Hirotaka , Ishida Hidenori , Ebe Yusuke , Hatta Tsuguru , Fukui Toshiki , Shimosawa Tatsuo , Katsuya Tomohiro , Taguchi Takashi , Tanabe Ayumi , Ohishi Mitsuru ,   on behalf of the EXCITE-HT investigators
Published: October 2024

Abstract
This prespecified subanalysis of the multicenter, randomized, open-label, parallel-group EXCITE-HT study aimed to examine the non-inferiority of esaxerenone to trichlormethiazide as a second-line antihypertensive agent according to the basal antihypertensive agent used (angiotensin receptor blocker [ARB] or calcium channel blocker [CCB]). The primary endpoint, change in morning home systolic/diastolic blood pressure (SBP/DBP) from baseline to end of treatment was similar between the two groups (intergroup difference in least squares mean change [95% confidence interval]: −1.3 [−3.8, 1.3]/−0.2 [−1.6, 1.3] mmHg for ARB; −2.7 [−4.2, −1.2]/−0.8 [−1.7, 0.1] mmHg for CCB). The respective incidences of serum potassium levels <3.5 mEq/L and ≥5.5 mEq/L in the ARB subgroup were 3.4% and 4.2% for esaxerenone and 7.9% and 0% for trichlormethiazide; in the CCB subgroup, they were 2.8% and 0.6% for esaxerenone and 13.9% and 1.2% for trichlormethiazide, respectively. The incidence of uric acid level ≥7.0 mg/dL was numerically higher in the trichlormethiazide group than the esaxerenone group in both the ARB and CCB subgroups. The non-inferiority of esaxerenone to trichlormethiazide in lowering morning home BP was demonstrated regardless of whether the basal antihypertensive agent was an ARB or CCB. Esaxerenone with a CCB showed superiority to trichlormethiazide in lowering SBP, without any new safety concerns. Serum potassium levels tended to be higher when esaxerenone was combined with an ARB than with a CCB, but this can be mitigated if administered according to the package insert.
Digital therapeutic for hypertension improves physician-patient communication and clinical inertia: a survey of physicians who implemented CureApp HT in clinical practice
Authors: Katsuya Tomohiro , Hisaki Fumi , Aga Mitsuharu , Hirayama Yumi , Takagi Yusuke , Ichikihara Yuko , Tanigawa Tomoyuki 
Published: October 2024

Abstract
In the 2019 Guidelines for the Management of Hypertension by the Japanese Society for Hypertension, lifestyle modification is recommended for all individuals except those with normal blood pressure. However, no detailed methods have been established to achieve the target blood pressure and resolve clinical inertia. CureApp HT, a digital therapeutic for hypertension that contributes to blood pressure reduction through lifestyle modification, was approved as software as a medical device for reimbursement by Japanese national health insurance in September 2022. This study aimed to survey physicians who implemented CureApp HT to assess how it changes physician-patient communication and contributes to clinical inertia resolution. A questionnaire survey was conducted at three time points: before the first prescription (first survey), 3 months (second survey), and 6 months (third survey) after the first prescription for physicians who had implemented CureApp HT. The primary outcome was the total score of five items on a Likert scale related to physician-patient communication, and it was analyzed based on the 47 physicians who responded to all three questionnaires. The total score of physician-patient communication significantly improved after 6 months of the introduction of CureApp HT, reflecting that physicians observed positive changes in patients’ knowledge and attitudes regarding hypertension treatment. Furthermore, the number of physicians who set a target home blood pressure of 125/75 mmHg for their patients significantly increased. CureApp HT allows physicians to recognize changes in patients’ disease knowledge and treatment attitudes, enabling them to set more stringent blood pressure targets and addressing clinical inertia.
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
Authors: Denos Marion , Sun Yi-Qian , Brumpton Ben Michael , Li Yafang , Albanes Demetrius , Burnett-Hartman Andrea , Campbell Peter T. , Küry Sébastien , Li Christopher I. , White Emily , Samadder Jewel N. , Jenkins Mark A. , Mai Xiao-Mei 
Published: October 2024

AbstractThe roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37–0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.
A microphysiological system for studying barrier health of live tissues in real time
Authors: Way Ryan , Templeton Hayley , Ball Daniel , Cheng Ming-Hao , Tobet Stuart A. , Chen Thomas 
Published: October 2024

AbstractEpithelial cells create barriers that protect many different components in the body from their external environment. Increased gut barrier permeability (leaky gut) has been linked to several chronic inflammatory diseases. Understanding the cause of leaky gut and effective interventions are elusive due to the lack of tools that maintain tissue’s physiological environment while elucidating cellular functions under various stimuli ex vivo. Here we present a microphysiological system that records real-time barrier permeability of mouse colon in a physiological environment over extended durations. The system includes a microfluidic chamber; media composition that preserves microbiome and creates necessary oxygen gradients across the barrier; and integrated sensor electrodes for acquiring transepithelial electrical resistance (TEER). Our results demonstrate that the system can maintain tissue viability for up to 72 h. The TEER sensors can distinguish levels of barrier permeability when treated with collagenase and low pH media and detect different thickness in the tissue explant.