bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generational (dis)agreements – family support, national law and older immigrants in extended households
Authors: LIVERSAGE ANIKA 
Published: December 2017

ABSTRACTAs detailed knowledge on multigenerational migrant families is sparse, this paper draws on quantitative and qualitative data to investigate intergenerational co-residence for older Turkish immigrants in Denmark. Registry data show that 23 per cent of Turkish immigrants in the 65–74 years age group live in intergenerational households – a level halfway between levels in Denmark and Turkey. These extended households are predominantly of the ‘culturally ideal’ type – formed by sons, sons’ wives and often the couple's children. One in five extended households, however, includes unwed sons and hence do not provide access to the labour power of daughters-in-law. Many factors seem to contribute to the observed pattern, including variable meanings of intergenerational co-habitation, high levels of poverty and limited housing options for extended families. Interviews with older Turkish immigrants point to another contributing factor, namely men's difficulties finding wives willing to live with parents-in-law. The sons’ hardships in this regard can be tied to a Danish immigration regime that bars marriage migrants from entering into extended households. While Turkish women raised in Denmark do not face such legal restrictions, such young women may reject marriage proposals entailing in-law co-habitation. The study thus adds new nuances to our understanding of how the dynamics of age, gender and immigration experience may shape the ways in which older immigrants live in Europe today.
The unwelcome houseguest: secondary household transmission of norovirus
Authors: MARSH Z. A. , GRYTDAL S. P. , BEGGS J. C. , LESHEM E. , GASTAÑADUY P. A. , RHA B. , NYAKU M. , LOPMAN B. A. , HALL A. J. 
Published: December 2017

SUMMARYNorovirus is the leading cause of acute gastroenteritis in the USA. Although secondary household transmission of norovirus is frequently reported in outbreaks, little is known about specific risk factors for susceptibility and infectiousness in the household. Three norovirus outbreaks were investigated and data were collected on individuals exposed in the primary outbreak setting and their household members. Potential individual- and household-level risk factors for susceptibility and infectiousness were assessed using univariate and multivariate generalised linear mixed models. In the univariate models, the secondary attack rate (SAR) was significantly higher when living in a household with two or more primary cases (incidence rate ratio (IRR) = 2·1; 95% confidence interval (CI) 1·37–3·29), more than one primary case with vomiting (IRR = 1·9; CI 1·11–3·37), and at least one primary case with diarrhoea (IRR = 3·0; CI 1·46–6·01). After controlling for other risk factors in the multivariate models, the SAR was significantly higher among those living in a household with two or more primary cases (adjusted IRR = 2·0; CI 1·17–3·47) and at least one primary case with diarrhoea (adjusted IRR = 2·8; CI 1·35–5·93). These findings underscore the importance of maintaining proper hygiene and isolating ill household members to prevent norovirus transmission in the household.
Effects of meal timing on changes in circulating epinephrine, norepinephrine, and acylated ghrelin concentrations: a pilot study
Authors: Bo Simona , Broglio Fabio , Settanni Fabio , Parasiliti Caprino Mirko , Ianniello Alice , Mengozzi Giulio , De Francesco Antonella , Fadda Maurizio , Fedele Debora , Guggino Alice , Ghigo Ezio , Maccario Mauro 
Published: December 2017

Abstract
Background
Timing of food intake impacts on metabolic diseases. Few data are available about post-meal changes in epinephrine (E), norepinephrine (NE), and acylated ghrelin (AG) at different times of the day.

Subjects and methods
This randomized cross-over trial investigated E/NE/AG concentrations after identical meals consumed at 0800 or 2000 hours in 20 healthy volunteers, by standardizing diet, exercise, duration of fast, and resting. Participants randomly received the test meal at 0800 or 2000 hours, and vice versa after 1 week. Blood samples were collected before and up to 180-min post-meal, every 30 min, with participants supine, motionless, but awake.

Results
Median E levels increased at 30–60 min, then declined and rose again at 150 min; values at 60 min (19.0 vs. 15.0 ng/l, p = 0.03) and 180 min (25.0 vs. 11.0 ng/l, p < 0.001) were higher after the morning meals. NE rose at 30–60 min and then progressively declined; median values at 60 min (235.3 vs. 206.3 ng/l, p = 0.02) and 120 min (208.8 vs. 142.0 ng/l, p = 0.04) increased more after morning meals. AG progressively declined to increase again at 90 min after meal; median AG area-under-the-curve (AUC) values were lower at morning (7206.8 vs. 8828.3 pg/mL×h). AG-AUC was inversely associated with diet-induced thermogenesis (β = −121.6; 95% CI −201.0 to 42.2; p = 0.009 for each unit increase), while log NE-AUC was inversely associated with log-triglyceride AUC (β = −0.57; 95% CI −0.98 to 0.16; p = 0.015) in a multiple regression model, after multiple adjustments.

Conclusions
In conclusion, E/NE concentrations were higher after the morning meal, while AG showed an opposite behavior. These data, although requiring confirmation in larger samples, suggest an adjunctive possible mechanism explaining the unfavorable effects of evening eating on metabolic risk
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation
Authors: Huang Yujie , Sun Yifei , Cao Yizhi , Sun Hui , Li Min , You Hui , Su Dongming , Li Yanjiao , Liang Xiubin 
Published: December 2017

AbstractApoptosis of renal tubular epithelial cells is a key feature of the pathogenicity associated with tubulointerstitial fibrosis and other kidney diseases. One factor that regulates important cellular processes like apoptosis and cell proliferation is HRD1, an E3 ubiquitin ligase that acts by promoting ubiquitylation and degradation of its target protein. However, the detailed mechanisms by which HRD1 acts as a regulator of apoptosis in renal tubular epithelial cells have not been established. In our previous liquid chromatography-tandem mass spectrometry (LC-MS/MS) study (Mol Endocrinol. 2016;30:600–613), we demonstrated that one substrate of HRD1 was eIF2α, a critical protein in the PERK-eIF2α-ATF4-CHOP signaling pathway of endoplasmic reticulum (ER) stress. Here, we show that eIF2α expression was increased and HRD1 expression decreased when apoptosis was induced in HKC-8 cells by palmitic acid (PA) or high glucose (HG). HRD1 expression was also lower in kidney tissues from mice with diabetic nephropathy (DN) than in control mice. Forced expression of HRD1 also inhibited apoptosis in HKC-8 cells, while HRD1 overexpression decreased the expression of phosphorylated eIF2α and eIF2α. Further analysis indicated that HRD1 interacted with eIF2α and promoted its ubiquitylation and degradation by the proteasome. Moreover, the HRD1 protection of PA-treated HKC-8 cells was blunted by transfection with Myc-eIF2α. Thus, eIF2α ubiquitylation by HRD1 protects tubular epithelial cells from apoptosis caused by HG and PA, indicating a novel upstream target for therapeutic prevention of renal tubulointerstitial injury.
CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
Authors: Jang Min Jun , Park Ui-Hyun , Kim Jeong Woo , Choi Hanbyeul , Um Soo-Jong , Kim Eun-Joo 
Published: December 2017

AbstractPeroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation and is closely linked to the development of obesity. Despite great progress in elucidating the transcriptional network of PPARγ, epigenetic regulation of this pathway by histone modification remains elusive. Here, we found that CDK2-associated cullin 1 (CACUL1), identified as a novel SIRT1 interacting protein, directly bound to PPARγ through the co-repressor nuclear receptor (CoRNR) box 2 and repressed the transcriptional activity and adipogenic potential of PPARγ. Upon CACUL1 depletion, less SIRT1 and more LSD1 were recruited to the PPARγ-responsive gene promoter, leading to increased histone H3K9 acetylation, decreased H3K9 methylation, and PPARγ activation during adipogenesis in 3T3-L1 cells. These findings were reversed upon fasting or resveratrol treatment. Further, gene expression profiling using RNA sequencing supported the repressive role of CACUL1 in PPARγ activation and fat accumulation. Finally, we confirmed CACUL1 function in human adipose-derived stem cells. Overall, our data suggest that CACUL1 tightly regulates PPARγ signaling through the mutual opposition between SIRT1 and LSD1, providing insight into its potential use for anti-obesity treatment.
Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature
Authors: Reismann David , Stefanowski Jonathan , Günther Robert , Rakhymzhan Asylkhan , Matthys Romano , Nützi Reto , Zehentmeier Sandra , Schmidt-Bleek Katharina , Petkau Georg , Chang Hyun-Dong , Naundorf Sandra , Winter York , Melchers Fritz , Duda Georg , Hauser Anja E. , Niesner Raluca A. 
Published: December 2017

AbstractThe bone marrow is a central organ of the immune system, which hosts complex interactions of bone and immune compartments critical for hematopoiesis, immunological memory, and bone regeneration. Although these processes take place over months, most existing imaging techniques allow us to follow snapshots of only a few hours, at subcellular resolution. Here, we develop a microendoscopic multi-photon imaging approach called LIMB (longitudinal intravital imaging of the bone marrow) to analyze cellular dynamics within the deep marrow. The approach consists of a biocompatible plate surgically fixated to the mouse femur containing a gradient refractive index lens. This microendoscope allows highly resolved imaging, repeatedly at the same regions within marrow tissue, over months. LIMB reveals extensive vascular plasticity during bone healing and steady-state homeostasis. To our knowledge, this vascular plasticity is unique among mammalian tissues, and we expect this insight will decisively change our understanding of essential phenomena occurring within the bone marrow.
Frustration-driven C
4 symmetric order in a naturally-heterostructured superconductor Sr2VO3FeAs
Authors: Ok Jong Mok , Baek S.-H. , Hoch C. , Kremer R. K. , Park S. Y. , Ji Sungdae , Büchner B. , Park J.-H. , Hyun S. I. , Shim J. H. , Bang Yunkyu , Moon E. G. , Mazin I. I. , Kim Jun Sung 
Published: December 2017

AbstractA subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity-coupled layer is magnetically active, rich phase diagrams are expected in FeSCs, but this has not been explored yet. Here, using high-accuracy 75As and 51V nuclear magnetic resonance measurements, we investigate an electronic phase that emerges in the FeAs layer below T0 ~ 155 K of Sr2VO3FeAs, a naturally assembled heterostructure of an FeSC and a Mott-insulating vanadium oxide. We find that frustration of the otherwise dominant Fe stripe and V Neel fluctuations via interfacial coupling induces a charge/orbital order in the FeAs layers, without either static magnetism or broken C4 symmetry, while suppressing the Neel antiferromagnetism in the SrVO3 layers. These findings demonstrate that the magnetic proximity coupling stabilizes a hidden order in FeSCs, which may also apply to other strongly correlated heterostructures.
Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic asthma: a longitudinal study
Authors: Lodin Karin , Lekander Mats , Syk Jörgen , Alving Kjell , Andreasson Anna 
Published: December 2017

AbstractAllergic asthma is a chronic inflammatory disorder associated with elevated levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide (FENO). Poor self-rated health and sickness behaviour has repeatedly been associated with inflammatory markers, but the nature of this relationship in chronic inflammatory disease is not known. Likewise, such findings largely rely on cross-sectional investigations. Self-rated health (How would you rate your general state of health?), sickness behaviour (mean rating of satisfaction with energy, sleep, fitness, appetite and memory), IgE, S-ECP, P-EDN, and FENO were assessed in 181 non-smoking primary care patients with asthma in a 1-year longitudinal study. Associations between repeated measurements were calculated using mixed regression models and Spearman’s correlations for change scores. Poor self-rated health was associated with high levels of seasonal IgE (p = 0.05) and food IgE (p = 0.04), but not total IgE or inflammatory markers. An increase over 1 year in perennial IgE was associated with a worsening of self-rated health (ρ = 0.16, p = 0.04). Poor self-rated health was associated with more pronounced sickness behaviour (p < 0.001), and a worsening in sickness behaviour was associated with a worsening of self-rated health over time (ρ = 0.21, p = 0.007). The study corroborates the importance of sickness behaviour as a determinant of self-rated health by showing that these factors co-vary over a 1-year period in a group of patients with allergic asthma. The importance of specific IgE for perceived health in primary care patients with mild to moderate asthma needs further investigation.
Fresnel diffractograms from pure-phase wave fields under perfect spatio-temporal coherence: Non-linear/non-local aspects and far-field behavior
Authors: Trost F. , Hahn S. , Müller Y. , Gasilov S. , Hofmann R. , Baumbach T. 
Published: December 2017

AbstractRecently, the diffractogram, that is, the Fourier transform of the intensity contrast induced by Fresnel free-space propagation of a given (exit) wave field, was investigated non-perturbatively in the phase-scaling factor S (controlling the strength of phase variation) for the special case of a Gaussian phase of width $$\sqrt{{\bf{w}}}$$

w

. Surprisingly, an additional low-frequency zero σ* = σ*(S, F) >0 emerges critically at small Fresnel number F (σ proportional to square of 2D spatial frequency). Here, we study the S-scaling behavior of the entire diffractogram. We identify a valley of maximum S-scaling linearity in the F − σ plane corresponding to a nearly universal physical frequency ξml = (0:143 ± 0.001)w−1/2. Large values of F (near field) are shown to imply S-scaling linearity for low σ but nowhere else (overdamped non-oscillatory). In contrast, small F values (far field) entail distinct, sizable s-bands of good S-scaling linearity (damped oscillatory). These bands also occur in simulated diffractograms induced by a complex phase map (Lena). The transition from damped oscillatory to overdamped non-oscillatory diffractograms is shown to be a critical phenomenon for the Gaussian case. We also give evidence for the occurrence of this transition in an X-ray imaging experiment. Finally, we show that the extreme far-field limit generates a σ-universal diffractogram under certain requirements on the phase map: information on phase shape then is solely encoded in S-scaling behavior.
Bouncing of an ellipsoidal drop on a superhydrophobic surface
Authors: Yun Sungchan 
Published: December 2017

AbstractDrop impact on superhydrophobic surfaces has received significant attention because of the advantages of self-cleaning and anti-icing attained by minimum contact time with the surface. Drop hydrodynamics is generally assumed to be axisymmetric, and the contact time is still bounded below by a theoretical Rayleigh limit. In this study, we report an ellipsoidal drop impact on a superhydrophobic surface to demonstrate an efficient way to reduce the contact time and suppress the bounce magnitude by breaking the symmetry. The outcome of the bounce is characterized in terms of a geometric aspect ratio (AR) and Weber number of the drop by comparing the dynamics with a spherical drop. The experimental result shows that the bouncing of the ellipsoidal drop can reduce the contact time and maximum bounce height below the spherical one by at least 30% and 60%, respectively. The exceptional rim dynamics at high AR produces a liquid alignment along the principal direction, leading to the symmetry breaking in the mass and momentum distribution and the subsequent fast drop detachment, which is quantitatively rationalized by the numerical study. The distinct features of the ellipsoidal drop impact will provide an insight into shape-dependent dynamics and open up new opportunities for self-cleaning and anti-icing strategies.
Blueprint for Large-Scale Silicon Optical Phased Array Using Electro-Optical Micro-Ring Pixels
Authors: Zhao Che , Peng Chao , Hu Weiwei 
Published: December 2017

AbstractWe propose a modularized architecture of a large-scale optical phased array (OPA) on a silicon on insulator (SOI) platform, using electro-optical (EO) pixels. Each pixel contains a directional coupler, a micro-ring phase shifter, and a grating optical antenna, on a compact configuration of area 50 μm × 50 μm, with optical and electrical interconnections. Moreover, we present an exemplary blueprint of an OPA consisting of 32 × 32 EO pixels, which sets the width of the main lobe as 0.04° × 0.04° and the field of view as 1.78°. By applying an over-coupled condition, the modulation efficiency and the accompanying intensity modulation are balanced, thus, the OPA performance is not severely degraded. The discussion on the fabrication tolerance shows that the proposed architecture is robust and feasible regarding the state-of-the-art fabrication process, and the performance of the main lobe width and field of view can be further optimized by a larger system size and smaller pixel size. Furthermore, the complexity of interconnections linearly depends on the number of rows and columns, making it highly scalable.
Two-colour serial femtosecond crystallography dataset from gadoteridol-derivatized lysozyme for MAD phasing
Authors: Gorel Alexander , Motomura Koji , Fukuzawa Hironobu , Doak R. Bruce , Grünbein Marie Luise , Hilpert Mario , Inoue Ichiro , Kloos Marco , Nass Kovács Gabriela , Nango Eriko , Nass Karol , Roome Christopher M , Shoeman Robert L , Tanaka Rie , Tono Kensuke , Foucar Lutz , Joti Yasumasa , Yabashi Makina , Iwata So , Ueda Kiyoshi , Barends Thomas R. M , Schlichting Ilme 
Published: December 2017

AbstractWe provide a detailed description of a gadoteridol-derivatized lysozyme (gadolinium lysozyme) two-colour serial femtosecond crystallography (SFX) dataset for multiple wavelength anomalous dispersion (MAD) structure determination. The data was collected at the Spring-8 Angstrom Compact free-electron LAser (SACLA) facility using a two-colour double-pulse beam to record two diffraction patterns simultaneously in one diffraction image. Gadolinium lysozyme was chosen as a well-established model system that has a very strong anomalous signal. Diffraction patterns from gadolinium lysozyme microcrystals were recorded to a resolution of 1.9 Å in both colours. This dataset is publicly available through the Coherent X-ray Imaging Data Bank (CXIDB) as a resource for algorithm development.
The mineralocorticoid receptor knockout in medaka is further validated by glucocorticoid receptor compensation
Authors: Sakamoto Tatsuya , Yoshiki Madoka , Sakamoto Hirotaka 
Published: December 2017

AbstractTo study the critical role of mineralocorticoid signalling, we generated a constitutive mineralocorticoid receptor (MR)-knockout (KO) medaka as the first adult-viable MR-KO animal. This KO medaka displayed abnormal behaviours affected by visual stimuli. In contrast, the loss of MR did not result in overt phenotypic changes in osmoregulation, despite the well-known osmoregulatory functions of MR in mammals. Since glucocorticoid receptor (GR) has been suggested to compensate for loss of MR, we examined expression of duplicated GRs with markedly different ligand sensitivities, in various tissues. qRT-PCR results revealed that the absence of MR induced GR1 in the brain and eyes, but not in osmoregulatory organs. This reinforces the important functions of glucocorticoid signalling, but the minor role of mineralocorticoid signalling, in fish osmoregulation. Because both 11-deoxycorticosterone (DOC) and cortisol are ligands for MR, whereas GRs are specific to cortisol, GR1 signalling may compensate for the absence of cortisol-MR, rather than that of DOC-MR. Thus, this GR expression suggests that our MR-KO model can be used specifically to characterize DOC-MR signalling.
Flat‐gain dual‐patch antenna with multi‐radiation nulls and low cross‐polarisation
Authors: Meng Chunmei , Shi Jin , Chen Jian‐Xin 
Published: December 2017

A coupled‐fed dual‐patch antenna with vias, stubs and a metallic shield is proposed. The proposed design shows all the key features of multi‐radiation nulls, low cross‐polarisation, wide bandwidth, high and flat gain, while the reported single‐patch and multi‐patch antennas have part of the features. One prototype operated at 10.3 GHz has been fabricated and measured. The measured results show a 10‐dB fractional bandwidth of 12.1%, the gain at the centre frequency is 8.7 dBi, and three radiation nulls appear at 7.6, 8.15 and 12.25 GHz, respectively. The cross‐polarisation is less than −25 dB. The gain ripple is 0.36 dB.
High‐efficiency PV inverter with SiC technology
Authors: Wall Simon , Hong Xiao‐Cong , Sha Long , Xie Jing‐Ren 
Published: December 2017

A high‐efficiency, three‐phase, solar photovoltaic (PV) inverter is presented that has low ground current and is suitable for direct connection to the low voltage (LV) grid. The proposed topology includes a three‐phase, two‐level (2L) voltage source inverter (VSI) and an active common‐mode (CM) filter. The VSI utilises silicon (Si) insulated‐gate bipolar transistors with silicon carbide (SiC) diodes to reduce switching losses and provide very high efficiency. The active CM filter reduces the high level of CM voltage associated with the three‐phase 2L VSI. The active CM filter is controlled so that the PV ground current is reduced to acceptable levels, even when the PV inverter is connected directly to a LV grid with low‐impedance grounding. 50 and 100 kW prototypes are presented that demonstrate high efficiency.
Performance of silver nanoparticle fixed on magnetic iron nanoparticles () in water disinfection
Authors: Sharifi Roya , Hassani Amir Hessam , Ahmad Panahi Homayon , Borghei Mehdi 
Published: December 2017

Microbial contamination poses a serious threat to human health. The evaluation of alternative systems and their reliability for the treatment of water is essential. In this work, a new method for the deposit of more silver nanoparticles (AgNPs) on the external surface of nanoparticles is presented. nanoparticles were synthesised by chemical co‐precipitation and were modified in two stages using 3‐mercaptopropyl trimethoxysilane and grafting allyl glycidyl ether and N, N‐dimethylacrylamide. Then, AgNPs were loaded onto the modified to be used for water disinfection. The resulting nanoparticles were characterised by transmission electron microscopy, X‐ray powder diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometer and thermal gravimetric analysis. Batch experiments were performed to investigate the effects of parameters such as amount of , contact time, and initial concentrations of MPN (the most probable number) and pH. The kinetic data was analysed by pseudo‐first‐order and pseudo‐second‐order equations. Results showed that the optimum conditions were a contact time of 30 min (94%), 50 mg of , and a pH was 6.5 for the maximum MPN removal efficiency (99.76%) in 750 cfu/ml MPN. On the basis of the results of fitting data, the pseudo‐second‐order kinetic model was selected as suitable for the data.