bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental cognitive neuroscience using Latent Change Score models: A tutorial and applications
Authors: Kievit Rogier A. , Brandmaier Andreas M. , Ziegler Gabriel , van Harmelen Anne-Laura , de Mooij Susanne M. M. , Moutoussis Michael , Goodyer Ian , Bullmore Ed , Jones Peter B. , Fonagy Peter ,   the NSPN Consortium, Lindenberger Ulman , Dolan Raymond J. 
Published: February 2017

AbstractAssessing and analysing individual differences in change over time is of central scientific importance to developmental neuroscience. However, the literature is based largely on cross-sectional comparisons, which reflect a variety of influences and cannot directly represent change. We advocate usinglatent change score(LCS) models in longitudinal samples as a statistical framework to tease apart the complex processes underlying lifespan development in brain and behaviour using longitudinal data. LCS models provide a flexible framework that naturally accommodates key developmental questions as model parameters and can even be used, with some limitations, in cases with only two measurement occasions. We illustrate the use of LCS models with two empirical examples. In a lifespan cognitive training study (COGITO, N=204 (N=32 imaging) on two waves) we observe correlated change in brain and behaviour in the context of a high-intensity training intervention. In an adolescent development cohort (NSPN, N=176, two waves) we find greater variability in cortical thinning in males than in females. To facilitate the adoption of LCS by the developmental community, we provide analysis code that can be adapted by other researchers and basic primers in two freely available SEM software packages (lavaan and Ωnyx).HighlightsWe describe Latent change score modelling as a flexible statistical toolKey developmental questions can be readily formalized using LCS modelsWe provide accessible open source code and software examples to fit LCS modelsWhite matter structural change is negatively correlated with processing speed gainsFrontal lobe thinning in adolescence is more variable in males than females
Consensus rank orderings of molecular fingerprints illustrate the ‘most genuine’ similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates
Authors: O’Hagan Steve , Kell Douglas B. 
Published: February 2017

AbstractWe compare several molecular fingerprint encodings for marketed, small molecule drugs, and assess how theirrank ordervaries with the fingerprint in terms of the Tanimoto similarity to the most similar endogenous human metabolite as taken from Recon2. For the great majority of drugs, the rank order variesvery greatlydepending on the encoding used, and also somewhat when the Tanimoto similarity (TS) is replaced by the Tversky similarity. However, for a subset of such drugs, amounting to some 10% of the set and a Tanimoto similarity of ~0.8 or greater, the similarity coefficient is relatively robust to the encoding used. This leads to a metric that, while arbitrary, suggests that a Tanimoto similarity of 0.75-0.8 or greater genuinely does imply a considerable structural similarity of two molecules in the drug-endogenite space. Although comparatively few (<10% of) marketed drugs are, in this sense,robustlysimilar to an endogenite, there is often at least one encoding with which theyaregenuinely similar (e.g. TS > 0.75). This is referred to as the Take Your Pick Improved Cheminformatic Analytical Likeness or TYPICAL encoding, and on this basis some 66% of drugs are within a TS of 0.75 to an endogenite.We next explicitly recognise that natural evolution will have selected for the ability to transportdietarysubstances, including plant, animal and microbial ‘secondary’ metabolites, that are of benefit to the host. These should also be explored in terms of their closeness to marketed drugs. We thus compared the TS of marketed drugs with the contents of various databases of natural products. When this is done, we find that some 80% of marketed drugs are within a TS of 0.7 to a natural product, even using just the MACCS encoding. For patterned and TYPICAL encodings, 80% and 98% of drugs are within a TS of 0.8 to (an endogenite or) an exogenous natural product. This implies strongly that it is theseexogeneous(dietary and medicinal) natural products that are more to be seen as the ‘natural’ substrates of drug transporters (as is recognised, for instance, for the solute carrier SLC22A4 and ergothioneine). This novel analysis casts an entirely different light on the kinds of natural molecules that are to be seen as most like marketed drugs, and hence potential transporter substrates, and further suggests that a renewed exploitation of natural products as drug scaffolds would be amply rewarded.
Strategic exploration in human adaptive control
Authors: Schulz Eric , Klenske Edgar D. , Bramley Neil R. , Speekenbrink Maarten 
Published: February 2017

AbstractHow do people explore in order to gain rewards in uncertain dynamical systems? Within a reinforcement learning paradigm, control normally involves trading off between exploration (i.e. trying out actions in order to gain more knowledge about the system) and exploitation (i.e. using current knowledge of the system to maximize reward). We study a novel control task in which participants must steer a boat on a grid, aiming to follow a path of high reward whilst learning how their actions affect the boat’s position. We find that participants explore strategically yet conservatively, exploring more when mistakes are less costly and practicing actions that will be required later on.
Comparative insights to the transportome ofNosema: a genus of parasitic microsporidians
Authors: Chetia Hasnahana , Kabiraj Debajyoti , Sharma Swagata , Bora Utpal 
Published: February 2017

AbstractNosema,a genus of parasitic microsporidia, causes pebrine disease in arthropods, including economically important silkworms and honeybees.Nosemahave gene-poor genomes shaped by loss of the metabolic pathways, as a consequence of continued dependence on host-derived substrates. As an act of counterbalance, they have developed an array of transporter proteins that allow stealing from their hosts. Here, we have identified the core set of twelve transporter families present inNosemagenus, viz.N. apis, N. bombycis, N. ceranaeandN. antheraeathroughin silicopipeline. Transportomes ofN. apis, N. bombycis, N. ceranaeandN. antheraeahave a dominant share of secondary carriers and primary active transporters. The comparatively rich and diverse transportome ofN. bombycisindicates the role of transporters in its remarkable capability of host adaptation. The core set of transporter families ofNosemaincludes ones that have a likely role in osmo-regulation, intra- and extra-cellular pH regulation, energy compensation and self-defence mechanism. This study has also revealed a set of ten species-specific transporter families within the genus. To our knowledge, this is the first ever intra-genus study on microsporidian transporters. Both these datasets constitutes a valuable resource that can aid in development of inhibitor-basedNosemamanagement strategies.
Gal4 activation domain 9aaTAD could be inactivated by adjacent mini-inhibitory domain and reactivated by distal re-activation domain
Authors: Piskacek Martin , Havelka Marek , Rezacova Martina , Knight Andrea 
Published: February 2017

AbstractThe characterisation of the activation domains started three decades ago with Gcn4 and Gal4 activators. The amorphous character of the activation domains strongly hindered their definition. Moreover, during the attempts to localise the Gal4 activation domain, the artificial peptides, an unintended consequence of cloning, were responsible for artificial transcriptional activity of the several Gal4 constructs. These artefacts produced enormous experimental bias and misconception. The presence of inhibitory domains in some Gal4 constructs made the misperception even worse. Previously, we reported that the nine amino acid transactivation domain, 9aaTAD, is the exclusive activation domain in the Gal4 protein. The activation domain 9aaTAD could be identified in Gal4 paralogs Oaf1, Pip2, Pdr1, Pdr3 and other activators p53, E2A and MLL. Surprisingly, the activation domain 9aaTAD was reported as misconception for Gal4 activator. Here we demonstrated that small region of 10 amino acids adjacent to the Gal4 activation domain 9aaTAD is an inhibitory domain, which the authors included in their constructs. Moreover, we identified Gal4 region, which was able to the reverse the inhibitory effect. The 9aaTAD re-activation domain was localized to the 13 amino acid long region. In this report we clarified the numerous confusions and rebutted supposed 9aaTAD misconception.SummaryThe activation domain 9aaTAD has decisive function in Gal4 activation. Gal4 activation domain 9aaTAD could be inhibited by adjacent region of 10 amino acids. The inhibited Gal4 activation domain 9aaTAD could be reactivated by 13 amino acid long Gal4 region. The activation domains 9aaTAD could be identified by our 9aaTAD prediction algorithm, especially in the Gal4 family.
The roles of deals and business networks in innovation processes
Authors: Olsen Per Ingvar , Håkansson Håkan 
Published: February 2017

Purpose
The purpose of this paper is to analyze the roles of deals in innovations processes, based on the definition of a deal as the interaction of social-material value-creating processes with money-handing processes.

Design/methodology/approach
The paper is based on a study of the historical emergence of transaortic valve implantation (TAVI) as an innovative new technology in the area of thoracic surgery in a global setting. The study is based on a combination of interviews and secondary data analysis.

Findings
The authors found that deals play important roles in innovation processes as critical junctions that mark entries to different phases and generate major shifts in location as well as combination of resources, activities and actors. These shifts include radical changes in control, where actors in possession of resources necessary to bring the project through the next phase, move in to take control – thereby expanding their businesses to new growth niches. Based on the analysis of seven deals, the authors argue that the innovation process is a combined push and pull process where later stage entrepreneurial interests play very significant roles. Deals may also represent radical turning points and moves of the projects that set the project off in a different direction, usually also associated with shifting ownership control rights through the innovation and scaling process. The authors also argue that inventions in the periphery will tend to move to the areas with the most competent relevant business networks capable of adopting and expanding the innovation to a global business operation. The innovation process is not primarily about creating new resources and activities, but about recombining existing resources, competencies and activities. Supplier networks play particularly important roles in these processes.

Research limitations/implications
The authors suggest that the study indicates that IMP researchers should turn more attention to studying business deals and financial flows and influences – in particular in studies of innovations and innovation processes – to investigate the mechanisms by which new innovations interact with and transform existing business networks.

Social implications
This work highlights why and how an innovation that may initiate anywhere in the periphery, will tend to move to the most competent and capable networks around the globe, that are the most relevant to the needs of the innovation project. Hence, the more powerful business networks and eco-systems will tend to pull interesting inventions in from their periphery, and grow them effectively.

Originality/value
The paper expands the efforts in IMP theorizing to include financial/monetary interactions more explicitly into business network theory. It also aims at clarifying core IMP arguments toward entrepreneurship research, in particular research on international new ventures.
Strategy from the perspective of contract manufacturers
Authors: Szalkai Zsuzsanna , Magyar Mária 
Published: February 2017

Purpose
The purpose of this paper is to investigate the strategy of contract manufacturers (CMs). The research question is the following: how can the strategy of CMs be explained? The purpose is to better understand this activity though using different theoretical approaches and analyzing two customer relationships of a Hungarian CM, Videoton Holding.

Design/methodology/approach
The primary theoretical background is the relational view of strategy, and the concept of the business model is used for the analysis. The authors confront the literature about this topic in strategic management using the industrial marketing and purchasing approach to strategy; namely, strategizing. Through the case study of Videoton the authors explore how the company became a highly developed CM from its origins as an original equipment manufacturer company.

Findings
Through comparing theory the authors have created a research framework which is adapted to the empirical findings. In the CM’s strategy it is crucial to understand how partners are able to synchronize key propositions, key resources and key actors while taking the network of the firms into consideration.

Originality/value
The paper is novel in that the authors investigate the strategy of a supplier from their own perspective, not that of a customer. Applying and contrasting different theoretical approaches to this particular topic may considered to be valuable as well.
Customer portfolios – challenges of internal and external alignment
Authors: Højbjerg Clarke Ann , Freytag Per Vagn , Zolkiewski Judith 
Published: February 2017

PurposeThe purpose of this paper is to extend the discussion about customer portfolios beyond simple identification of models and how they can be used for balanced resource allocation to a discussion about how portfolios should take into account views from relationship partners and how they should be aligned in internal as well as a relational context.Design/methodology/approachThe portfolio literature is reviewed (most recent, seminal, IMP related) and considered in the context of both the sales organization and the customers involved in the portfolio. A conceptual framework is introduced that helps improve the understanding of how customer portfolio models can actually be applied from a relational perspective.FindingsThe key aspects of the conceptual framework relate to how alignment of the relationships in the portfolio is achieved. Critical to this are the interaction spaces that facilitate communication relating to alignment and provide the context for the legitimacy of these actions to be discussed.Research limitations/implicationsThis framework needs to be empirically explored.Practical implicationsUnderstanding of alignment and misalignment processes in customer portfolios gives managers a tool to help to cope with the dynamic aspects of the customer portfolio. Recognition of the importance of communication to the process, the development of trust and the role of legitimacy also provides areas that managers can focus upon in their relationship management processes.Originality/valueThis conceptualization moves the consideration of relationship/customer portfolios beyond simply that of a resource allocation tool into a process that facilitates the use of the portfolio in relational processes and thus aids their understanding of how portfolios can be usefully applied.
Total productive maintenance and manufacturing performance improvement
Authors: Hooi Lai Wan , Leong Tat Yuen 
Published: February 2017

Purpose
The purpose of this paper is to examine the multidimensionality of total productive maintenance (TPM) and its relationship with manufacturing performance improvement in the Malaysian manufacturing sector. Specifically, this study evaluates the contribution of each TPM success factors in improving manufacturing performance.

Design/methodology/approach
Data from 89 employees who participated in the survey were used to test the proposed research framework. A structured questionnaire adopted from Ahuja and Khamba (2006) was used to assess the Malaysian context.

Findings
The analytical results reveal that traditional maintenance initiatives and TPM implementation initiatives significantly affect manufacturing performance, but not top management leadership and maintenance organisation. Top management roles and commitment are critical in the early stage to determine the master plan and initiate the implementation of the whole programme. However, traditional maintenance and TPM implementation initiatives gradually enable engagement, proper planning, right execution and continuous improvement, ultimately improving the manufacturing performance indicators significantly. The findings further unveil that TPM is not sustainable in Malaysia’s manufacturing organisations in the long run.

Practical implications
This analysis is vital for senior managers of manufacturing organisations that have implemented TPM or are considering introducing TPM in their organisations.

Originality/value
This study contributes to the literature by examining beyond the introduction and stabilisation phase of TPM to provide an insight of whether TPM is sustainable in the long run.
Risk assessment of mining projects in Ghana
Authors: Amoatey Charles Teye , Famiyeh Samuel , Andoh Peter 
Published: February 2017

Purpose
The purpose of this paper is to assess the critical risk factors affecting mining projects in Ghana.

Design/methodology/approach
A purposive sampling approach was used in selecting the respondents for the study. These were practitioners working on mining projects in Ghana.

Findings
The study identified 22 risk factors contributing to mining project failure in Ghana. The five most critical mining project risk factors based on both probability of occurrence and impact were unstable commodity prices, inflation/exchange rate, land degradation, high cost of living and government bureaucracy for obtaining licenses. Mitigation measures for addressing the identified risk factors were identified.

Research limitations/implications
This paper is limited to data collected from practitioners working on mining projects. Due to geographic and logistical constraints, the study did not include the perception of local communities in quantifying the risk factors.

Practical implications
This paper has documented the critical risk factor affecting the mining industry in Ghana. Though the identified risk types are also prevalent in other sectors of the construction industry, the key findings of this paper emphasize the need for a comprehensive risk management culture in the mining sector. From an academic research perspective, the paper contributes to a conceptual risk assessment framework.

Originality/value
The information gathered through this research can be utilized in identifying and understanding risks during the early stages of mining project implementation.
The European standards and guidelines for internal quality assurance
Authors: Manatos Maria J. , Sarrico Cláudia S. , Rosa Maria J. 
Published: February 2017

Purpose
The authors’ thesis statement is that the literature on quality management in higher education is evolving towards an idea of integration. Considering Part 1 of the Standards and Guidelines for Quality Assurance in the European Higher Education Area (ESG) (ENQA, 2009) to be a framework for the implementation of quality management practices in universities, the purpose of this paper is to understand whether the ESG represent a truly integrated quality management model.

Design/methodology/approach
The authors analyse the content of the ESG taking into account three levels of analysis: the process level, the organisational level and the quality management principles level.

Findings
The analysis shows that the ESG are a quality management model, covering different processes, organisational levels and quality management principles. This is despite not being a truly integrated quality management model. Indeed, the ESG are mainly focussed on teaching and learning and on support processes, neglecting other processes of universities, such as research and scholarship and the third mission. In addition, they leave aside quality management principles more directly linked with a systemic and holistic approach to quality, such as the system approach principle.

Originality/value
The paper presents a new analysis of a much discussed quality management model for higher education. It explores the ESG in the light of the concept of integration, discussed according to a new framework of analysis. It also highlights the importance of a broader reflection on these standards and of their integration in the management systems of institutions.
Risk-based thinking according to ISO 9001:2015 standard and the risk sources European manufacturing SMEs intend to manage
Authors: Chiarini Andrea 
Published: February 2017

PurposeThe purpose of this paper is to theorize and prioritize the main categories of risk sources for the European manufacturing small- and medium-sized enterprises (SMEs) in accordance with the International Organization for Standardization (ISO) 9001:2015 requirement “risk based thinking.” Furthermore, the research analyses how these organizations intend to manage the risks and their effects.Design/methodology/approachA first exploratory interview with 28 experts from international certification bodies and manufacturing companies which revealed 11 risk sources has been performed. Then, quality managers from European manufacturing SMEs were surveyed to determine whether or not they intended to manage the risk sources suggested by the experts. A 95 percent confidence interval was performed to evaluate the range of plausible values for the population. The quality managers were also asked to comment on each category of risk source.FindingsThe research shows that the most taken into account categories of risk sources were the internal production of nonconforming products followed by poorly trained workers with a lack of skills and awareness, supplier nonconforming products and lack of risk-based assessment. The least taken into account category was nonconforming technical results in the design process. The quality managers’ qualitative comments also brought to light interesting issues which represented avenues for new research.Research limitations/implicationsThe limitations of this research lie in the first exploratory interview with the 28 experts. This process could be improved by means of a larger sample of experts. Furthermore, these experts could have included risk source categories which could fall outside of an ISO 9001 quality management system (QMS) scope and application.Practical implicationsQuality managers in SMEs can now address the new ISO 9001:2015 requirement knowing what the priorities from a statistical point of view are. This implication is also relevant to QMS consultants who are implementing ISO 9001:2015 QMS together with their customers.Originality/valueThe novelty of this research is that it has been tried for the first time to theorize what the main categories of risk sources in accordance with the risk-based thinking requirement are for European manufacturing SMEs.