bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolapse surgery with or without incontinence procedure: a systematic review and meta‐analysis
Authors: van der Ploeg JM , van der Steen A , Zwolsman S , van der Vaart CH , Roovers JPWR 
Published: September 2017

BackgroundTo reduce the risk of postoperative stress urinary incontinence (POSUI) prolapse repair might be combined with incontinence surgery.ObjectivesCompare efficacy and safety of prolapse surgery with and without incontinence surgery.Search strategyIncluding our earlier review a systematic search in PubMed, EMBASE, the Cochrane Library and the Register of Current Controlled Trials was performed from 1995 to 2017.Selection criteriaRandomised trials comparing prolapse surgery with a midurethral sling (MUS) or Burch colposuspension.Data collection and analysisTwo reviewers selected eligible articles and extracted data. Stress urinary outcomes were pooled for preoperative SUI. Urgency incontinence and adverse events were pooled for incontinence procedure.Main resultsTen trials were included. Women with preoperative SUI symptoms or occult SUI had a lower risk to undergo subsequent incontinence surgery for POSUI after vaginal prolapse surgery with a MUS than after prolapse surgery only: 0 versus 40% [relative risk (RR) 0.0; 95% CI 0.0–0.2] and 1 versus 15% (RR 0.1; 95% CI 0.0–0.6), respectively. These differences were not significant in continent women not tested for occult SUI or without occult SUI. Serious adverse events were more frequent after vaginal prolapse repair with MUS (14 versus 8%; RR 1.7; 95% CI 1.1–2.7), but not after sacrocolpopexy with Burch colposuspension. Combination surgery did not increase the risk of overactive bladder symptoms, urgency incontinence and surgery for voiding dysfunction.ConclusionsVaginal prolapse repair with MUS reduced the risk of postoperative SUI in women with preoperative SUI symptoms or occult SUI, but serious adverse events were more frequent.Tweetable abstractLess stress incontinence after vaginal prolapse repair with sling, but more adverse events.
Functional airway obstruction observed with hyperpolarized 129Xenon‐MRI
Authors: Song Erin J , Kelsey Chris R , Driehuys Bastiaan , Rankine Leith 
Published: September 2017

SummaryHyperpolarized 129Xenon‐MRI (HP 129Xe MRI) is an emerging imaging modality that allows assessment of both ventilation and gas transfer. Most research to date has focused on non‐malignant pulmonary diseases. However, the capability of evaluating the two primary physiological processes of the lung (ventilation and gas transfer) makes HP 129Xe MRI a promising imaging modality in the management of patients with lung cancer.
Protection against cold – a survey of available equipment in Swedish pre‐hospital services
Authors: Henriksson O. , Björnstig U. , Saveman B.‐I. , Lundgren P. J. 
Published: September 2017

BackgroundThe aim of this study was to survey the current equipment used for prevention, treatment and monitoring of accidental hypothermia in Swedish pre‐hospital services.MethodsA questionnaire was sent to all road ambulance services (AS), the helicopter emergency medical services (HEMS), the national helicopter search and rescue service (SAR) and the municipal rescue services (RS) in Sweden to determine the availability of insulation, active warming, fluid heating, and low‐reading thermometers.ResultsThe response rate was 77% (n = 255). All units carried woollen or polyester blankets for basic insulation. Specific windproof insulation materials were common in the HEMS, SAR and RS units but only present in about half of the AS units. Active warming equipment was present in all the SAR units, but only in about two‐thirds of the HEMS units and about one‐third of the AS units. About half of the RS units had the ability to provide a heated tent or container. Low‐reading thermometers were present in less than half of the AS and HEMS units and were non‐existent in the SAR units. Pre‐warmed intravenous fluids were carried by almost all of the AS units and half of the HEMS units but infusion heaters were absent in most units.ConclusionBasic insulation capabilities are well established in the Swedish pre‐hospital services. Specific wind and waterproof insulation materials, active warming devices, low‐reading thermometers and IV fluid heating systems are less common. We suggest the development and implementation of national guidelines on accidental hypothermia that include basic recommendations on equipment requirements.
Choledochal Cyst with 17q12 Chromosomal Duplication
Authors: Kotalova Radana , Dusatkova Petra , Drabova Jana , Elblova Lenka , Dedic Tomas , Cinek Ondrej , Lebl Jan , Pruhova Stepanka 
Published: September 2017

SummaryThe 17q12 chromosomal region carries the HNF1B gene, mutations of which cause various conditions. When searching for HNF1B/17q12 rearrangements among children with biliary atresia and/or choledochal cysts, we identified a male proband carrying a 17q12 duplication spanning 1698 kb that included 24 genes from TBC1D3C to HNF1B. The boy presented with cholestatic jaundice at the age of 2 weeks due to a choledochal cyst sized 15 ×12 mm (type Ia according to the Todani classification). He underwent a shunt surgery consisting of a hepaticojejunostomy using Roux‐en‐Y loop at the age of 2 months, which led to a permanent relief of cholestasis. Perioperative liver histology revealed significant hepatic fibrosis and bile ductular proliferation. At 17 years, he has a mildly enlarged liver with decreased elasticity, an upper‐normal–sized spleen, normal biochemistry values, and no renal or hepatic cysts. We report the first hepatobiliary phenotype in a patient with an HNF1B overdosage.
Cerebral oximetry and postoperative delirium after cardiac surgery: a randomised, controlled trial
Authors: Lei L. , Katznelson R. , Fedorko L. , Carroll J. , Poonawala H. , Machina M. , Styra R. , Rao V. , Djaiani G. 
Published: September 2017

SummaryPostoperative delirium is associated with increased morbidity and mortality. We hypothesised that restoration of regional cerebral oxygen desaturation would reduce the incidence of postoperative delirium in elderly patients after cardiac surgery. After institutional ethics review board approval and informed consent, a double‐blinded, prospective, randomised, controlled trial was conducted in patients ≥ 60 years of age undergoing cardiac surgery with cardiopulmonary bypass. In the intervention group, an algorithm was commenced if regional cerebral oxygen saturation decreased below 75% of baseline value for 1 min or longer. In the control group, the cerebral oximetry monitor screen was electronically blinded. Assessment of delirium was performed with confusion assessment method for intensive care unit or confusion assessment method after discharge from intensive care unit at 12‐h intervals for seven postoperative days. Postoperative delirium was present in 30 out of 123 (24.4%) and 31 out of 126 (24.6%) patients in the intervention and control groups, respectively, odds ratio 0.98 (95%CI 0.55–1.76), p = 0.97. Postoperative delirium was present in 20 (71%) out of 28 and in 41 (18%) out of 221 patients with baseline regional cerebral oxygen saturation ≤ 50, or > 50%, respectively, p = 0.0001. Higher baseline regional cerebral oxygen saturation and body mass index were protective against postoperative delirium. Restoration of regional cerebral oxygen desaturation did not result in lower postoperative delirium after cardiac surgery. Pre‐operative regional cerebral oxygen saturation ≤ 50% was associated with increased postoperative delirium rates in elderly patients following cardiac surgery.
Empirical Null Estimation Using Zero-inflated Discrete Mixture Distributions and Its Application to Protein Domain Data
Authors: Gauran Iris Ivy M. , Park Junyong , Lim Johan , Park DoHwan , Zylstra John , Peterson Thomas , Kann Maricel , Spouge John L. 
Published: September 2017

SummaryIn recent mutation studies, analyses based on protein domain positions are gaining popularity over gene-centric approaches since the latter have limitations in considering the functional context that the position of the mutation provides. This presents a large-scale simultaneous inference problem, with hundreds of hypothesis tests to consider at the same time. This article aims to select significant mutation counts while controlling a given level of Type I error via False Discovery Rate (FDR) procedures. One main assumption is that the mutation counts follow a zero-inflated model in order to account for the true zeros in the count model and the excess zeros. The class of models considered is the Zero-inflated Generalized Poisson (ZIGP) distribution. Furthermore, we assumed that there exists a cut-off value such that smaller counts than this value are generated from the null distribution. We present several data-dependent methods to determine the cut-off value. We also consider a two-stage procedure based on screening process so that the number of mutations exceeding a certain value should be considered as significant mutations. Simulated and protein domain data sets are used to illustrate this procedure in estimation of the empirical null using a mixture of discrete distributions. Overall, while maintaining control of the FDR, the proposed two-stage testing procedure has superior empirical power.
More than just side‐effects: The role of clinical and psychosocial factors in non‐adherence to tamoxifen
Authors: Moon Zoe , Moss‐Morris Rona , Hunter Myra S. , Hughes Lyndsay D. 
Published: September 2017

ObjectivesTamoxifen non‐adherence is apparent in up to half of breast cancer survivors and is associated with increased risk of recurrence and reduced quality of life. However, factors contributing to non‐adherence in this population are currently poorly understood. This study explored the relationship between key components of the Common Sense Model of Illness Representations (CSM)/the Theory of Planned Behaviour (TPB) and intentional and unintentional non‐adherence in a large sample of women prescribed tamoxifen following primary breast cancer.DesignCross‐sectional questionnaire study (n = 777).MethodsWomen were eligible if they were over 18, had been diagnosed with primary breast cancer, and had been prescribed tamoxifen. Participants were recruited in clinic or online and completed questionnaires assessing illness perceptions, treatment beliefs, adherence, quality of life, social support, distress, and the key TPB components. Logistic regressions were conducted to test elements from each model and to identify correlates of intentional and unintentional non‐adherence.ResultsPatients were classified as non‐adherent based on Medication Adherence Rating Scale scores; 44% of the population were non‐adherent; 41% reported unintentional non‐adherence, and 9% reported intentional non‐adherence. Study variables accounted for more variance in intentional (Nagelkerke R2 = 46%) than unintentional non‐adherence (Nagelkerke R2 = 17%). Intentional non‐adherence was best explained by a combination of TPB and CSM variables, but these variables did not contribute significantly to unintentional non‐adherence.ConclusionsThe TPB and the CSM provide a useful framework for understanding intentional tamoxifen non‐adherence. Elements from both models should be considered when designing interventions to increase adherence rates.
Statement of contribution

What is already known about this subject?

Non‐adherence to tamoxifen is common and is associated with poor clinical outcomes.

Few modifiable predictors of tamoxifen non‐adherence have been identified.

What does this study add?

Unintentional non‐adherence is reported much more frequently than intentional non‐adherence.

Elements from the CSM and TPB provide a useful framework for understanding non‐adherence to tamoxifen.

Unique correlates were found for intentional and unintentional non‐adherence.
Personalized peptide vaccination as second‐line treatment for metastatic upper tract urothelial carcinoma
Authors: Suekane Shigetaka , Ueda Kousuke , Nishihara Kiyoaki , Sasada Tetsuro , Yamashita Takuto , Koga Noriko , Yutani Shigeru , Shichijo Shigeki , Itoh Kyogo , Igawa Tsukasa , Noguchi Masanori 
Published: September 2017

This study investigated the applicability of personalized peptide vaccination (PPV) for patients with metastatic upper tract urothelial cancer (mUTUC) after failure of platinum‐based chemotherapy. In this single arm, open‐label, phase II clinical trial, patients with mUTUC received PPV at a single institution. Personalized peptide vaccination treatment used a maximum of four peptides chosen from 27 candidate peptides according to human leukocyte antigen types and peptide‐reactive IgG titers, for six s.c. injections weekly as one cycle. The safety of PPV, as well as its influence on host immunity and effect on overall survival were assessed. Forty‐eight patients were enrolled in this study. Personalized peptide vaccinations were well tolerated without severe adverse events. Median survival time was 7.3 months (95% confidence interval [CI], 5.3–13.1) with 13.0 months for patients receiving combined salvage chemotherapy (95% CI, 5.7–17.5) and 4.5 months for patients receiving PPV alone (95% CI, 1.7–10.1) (P = 0.080). Patients with positive CTL responses showed a significantly longer survival than patients with negative CTL responses (hazard ratio, 0.37; 95% CI, 0.16–0.85; P = 0.019). Multivariate Cox regression analysis showed that lower numbers of Bellmunt risk factors and lower levels of B‐cell activating factor were significantly associated with favorable overall survival for patients under PPV treatment. This study indicated that PPV for patients with mUTUC after failure of platinum‐based chemotherapy induced substantial peptide‐specific CTL responses without severe adverse events and has the potential to prolong survival when combined with salvage chemotherapy.UMIN Clinical Trials Registry ID: 000001854.
Contact dermatitis caused by tulips: identification of contact sensitizers in tulip workers of Kashmir Valley in North India
Authors: Hassan Iffat , Rasool Farhan , Akhtar Saniya , Kamili Afifa , Rather Parvaiz , Kanth Raihana , Bhat Yasmeen , Rather Shagufta , Mubashir Syed , Yaseen Atiya , Bashir Safia 
Published: September 2017

SummaryBackgroundTulip, belonging to the genus Tulipa and family Liliaceae, is a spring‐blooming perennial that grows from bulbs. Owing to manual handling, contact dermatitis can occur in professionals at any stage of the growth cycle of the tulip plant.ObjectivesTo determine the clinical pattern of contact dermatitis resulting from tulip plant cultivation, and to assess contact allergy in workers coming into contact with this plant.MethodsOne hundred and sixty‐four tulip workers were screened, and 48 patients with suspected contact dermatitis were patch tested with 39 allergens, including haptens from the Indian baseline series, a plant series, and extracts from different parts of the tulip plant.ResultsThirty‐nine positive patch test reactions were observed in 21 patients. Seventeen patients showed positive reactions to either α‐methylene‐γ‐butyrolactone or to tulip plant extract. Clinical relevance was observed for 13 of 17 positive patch test reactions.ConclusionsContact dermatitis is an important health hazard in workers dealing with tulip bulbs. Further studies to identify and isolate other possible tulip allergens, and to quantify the amounts of allergens in different parts of the tulip plant, are recommended.
Contact allergy to lanolin: temporal changes in prevalence and association with atopic dermatitis
Authors: Fransen Marloes , Overgaard Line E. K. , Johansen Jeanne D. , Thyssen Jacob P. 
Published: September 2017

SummaryBackgroundLanolin has been tested as lanolin alcohols (30% pet.) in baseline patch test series since 1969, and this has shown clinically relevant allergic contact dermatitis cases.ObjectivesTo investigate the temporal development of lanolin allergy (i.e. positive reaction to lanolin alcohols and/or Amerchol™ L‐101), and the association between contact allergy to lanolin and patient characteristics from the MOAHLFA index.MethodsA retrospective observational study of consecutively patch tested dermatitis patients (n = 9577) between 1 January 2004 and 31 December 2015 with lanolin alcohols 30% pet. and Amerchol™ L‐101 50% pet. was performed.ResultsThe prevalence of lanolin allergy increased from 0.45% in 2004 to 1.81% in 2015. In age‐adjusted and sex‐adjusted analyses, weak, significant associations were found between atopic dermatitis and lanolin and lanolin alcohols allergy, respectively, but no association with Amerchol™ L‐101 allergy was found. Among 9286 dermatitis patients who were tested with both allergens, 108 had a positive test reaction to either lanolin alcohols or Amerchol™ L‐101, whereas only 29 patients had positive test reactions to both markers.ConclusionsThe prevalence of lanolin contact allergy has increased over a 12‐year period, and inclusion of Amerchol™ L‐101 will increase the chance of detecting lanolin contact allergy. Patch testing with lanolin is helpful in atopics with dermatitis and suspected cosmetic allergy.
Clinical impact ofKMT2C andSPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patients
Authors: Kayser Sabine , Feszler Maximilian , Krzykalla Julia , Schick Matthias , Kramer Michael , Benner Axel , Thol Felicitas , Platzbecker Uwe , Müller‐Tidow Carsten , Ho Anthony D. , Ehninger Gerhard , Heuser Michael , Schlenk Richard F. , Thiede Christian , Röllig Christoph , Krämer Alwin 
Published: September 2017

AbstractObjectiveTo evaluate the prognostic impact of gene expression levels (ELs) of two tumor suppressor genes, sprouty 4 (SPRY4, located on 5q) and lysine methyltransferase 2C (KMT2C, located on 7q) in correlation with clinical characteristics and genetic abnormalities assessed at initial diagnosis in acute myeloid leukemia (AML).MethodGene expression levels were measured oncDNAbyRT‐qPCRfrom diagnostic bone marrow samples of 275 intensively treated adultAMLpatients (median age, 48 years).ResultsKMT2CELs were significantly lower in abn7q/‐7 (P = .001), whereasSPRY4ELs were not associated with abn5q/‐5. HigherKMT2C andSPRY4ELs were significantly associated with lower genetic risk groups as defined by the European LeukemiaNet classification. Additionally,KMT2CELs were lower in cytogenetically normal patients withDNMT3A(P = .01) orFLT3‐ITDmutations (P = .05).KMT2CELs were not associated with prognosis, whereas higherSPRY4ELs showed a favorable impact on event‐free (EFS,P = .01), relapse‐free (RFS,P = .01) and in‐trend on overall survival (P = .06) for cytogenetically abnormal patients, which was confirmed in multivariable analysis forEFS(HR, 0.84; 95%‐CI, 0.73‐0.97;P = .02) andRFS(HR, 0.85; 95%‐CI, 0.73‐0.98;P = .02).ConclusionOur data indicate thatKMT2CELs are associated with specific genetic features and thatSPRY4ELs may add prognostic information.
In situ monitoring of particle fracture in aluminium alloys
Authors: Wisner B. , Kontsos A. 
Published: September 2017

AbstractMaterial damage at the microscale involves both initiation and interaction effects that are typically activated long before the appearance of macroscopically observable failure events. These early appearances of damage have been broadly classified as microstructure‐sensitive damage precursors or indicators. A particular class of such precursors which is of importance to aluminium and other precipitate‐hardened alloys is the focus of this article. Specifically, the hard, intermetallic particles in aluminium alloys fracture before significant failure occur in the surrounding matrix. In this investigation, an effort to directly assess particle fracture activity at the time and scale that it occurs is made by coupling mechanical testing inside a scanning electron microscope with nondestructive evaluation techniques including digital image correlation as well as real‐time acoustic emission monitoring. The use of a surface measurement technique along with a volumetric monitoring method at the microscope scale provides a way for coupling of fracture information at locations which are directly related to the particle activity. In this article, Al2024‐T3 specimens in the as‐received condition were subjected to tension as well as to tension‐tension cyclic loading. The obtained in situ results demonstrate, for the first time to the best knowledge of the authors, that particle fracture occurs early in the damage process which justifies its characterization as a material damage precursor. The overall approach provides datasets capable to detect particle fracture initiation, which could become useful in future structural health monitoring applications.
The Importance of Integrating Supply‐Side Factors in Economic Base Models
Authors: Vollet Dominique , Aubert Francis , Frère Quentin , Lépicier Denis , Truchet Stéphanie 
Published: September 2017

AbstractEconomic base (or export‐base) theory (EBT) is often presented as a Keynesian‐inspired theory that only accounts for demand‐side factors. However, the recent integration of supply‐side factors into economic base models (EBMs) can contribute to renewing applications of this type of model in regional economics. This paper proposes a literature review focused on new EBMs that explicitly take into account supply effects and includes both North American and European studies. It first explains why integrating supply‐side factors is relevant for EBMs. Second, the paper shows how to integrate these supply‐side factors into the various types of models, focusing on two production factors: land and its amenities and labor. Third, the paper discusses the conditions for integrating such supply‐side factors into EBMs.
Evaluating Renewable Groundwater Stress with GRACE Data in Greece
Authors: Gemitzi Alexandra , Lakshmi Venkat 
Published: September 2017

AbstractGroundwater is a resilient water source and its importance is even greater in periods of drought. Areas such as the Mediterranean where adverse climate change effects are expected are bell‐weather locations for groundwater depletion and are of considerable interest. The present study evaluates renewable groundwater stress (RGS) as the ratio of groundwater use to groundwater availability, quantifying use as the trend in gravity recovery and climate experiment‐derived (GRACE) subsurface anomalies (ΔGWtrend) and renewable groundwater availability as mean annual recharge. Estimates for mean annual recharge for the various regions in Greece have been derived using numerical models. Our results highlight two RGS regimes in Greece (variable stress and unstressed) of the four characteristic stress regimes, that is, overstressed, variable stress, human‐dominated stress, and unstressed, defined as a function of the sign of use and the sign of groundwater availability (positive or negative). Variable stress areas are found in Central Greece (Thessaly region), where intensive agriculture results in negative ΔGWtrend values combined with positive mean annual recharge rates. RGS values range from −0.05 to 0, indicating a low impact area. Within this region, adverse effects of groundwater overexploitation are already evident based on the negative GRACE anomalies; however, recharge is still positive, mitigating the effects of over‐pumping. The rest of Greek aquifers fall within the unstressed category, with RGS values from 0.02 to 0.05, indicating that the rate of use is less than the natural recharge rate.