bluuebunny/crossref_metadata_2025_split huggingface dataset:
It's my partner, deal with it: Rejection sensitivity, normative beliefs, and commitment
Authors: BESIKCI EZGI , AGNEW CHRISTOPHER R. , YILDIRIM ASIYE 
Published: May 2016

AbstractPast research has shown that normative beliefs, or perceptions of (dis)approval from social network members regarding one's romance, significantly predict relationship commitment. We investigated sensitivity to rejection as a moderator of the normative beliefs–commitment association. We tested and found support for the moderating effect of rejection sensitivity (RS; Study 1) and sensitivity specific to rejection of one's current romantic partner (Study 2) on the normative beliefs–commitment link. The link was significantly stronger for people with lower levels of RS: People who were less sensitive to rejection indicated lower levels of commitment when they perceived less network approval for their relationship. In contrast, people with higher levels of RS indicated higher levels of commitment in the face of less perceived network approval.
Albumin–Folate Conjugates for Drug‐targeting in Photodynamic Therapy
Authors: Butzbach Kathrin , Rasse‐Suriani Federico A.O. , Gonzalez M. Micaela , Cabrerizo Franco M. , Epe Bernd 
Published: May 2016

AbstractPhotodynamic therapy (PDT) is based on the cytotoxicity of photosensitizers in the presence of light. Increased selectivity and effectivity of the treatment is expected if a specific uptake of the photosensitizers into the target cells, often tumor cells, can be achieved. An attractive transporter for that purpose is the folic acid receptor α (FRα), which is overexpressed on the surface of many tumor cells and mediates an endocytotic uptake. Here, we describe the synthesis and photobiological characterization of polar β‐carboline derivatives as photosensitizers covalently linked to folate‐tagged albumin as the carrier system. The particles were taken up by KB (human carcinoma) cells within <90 min and then co‐localized with a lysosomal marker. FRα antibodies prevented the uptake and also the corresponding conjugate without folate was not taken up. Accordingly, a folate‐albumin‐β‐carbolinium conjugate proved to be phototoxic, while the corresponding albumin–β‐carbolinium conjugates without FA were nontoxic, both with and without irradiation. An excess of free folate as competitor for the FRα‐mediated uptake completely inhibited the photocytotoxicity. Interestingly, the albumin conjugates are devoid of photodynamic activity under cell‐free conditions, as shown for DNA as a target. Thus, phototoxicity requires cellular uptake and lysosomal degradation of the conjugates. In conclusion, albumin–folate conjugates appear to be promising vehicles for a tumor cell targeted PDT.
Comparative population structure and trichothecene mycotoxin profiling of Fusarium graminearum from corn and wheat in Ontario, central Canada
Authors: Burlakoti R. R. , Tamburic‐Ilincic L. , Limay‐Rios V. , Burlakoti P. 
Published: May 2016

Fusarium graminearum causes fusarium head blight (FHB) of wheat and gibberella ear rot (GER) of corn in Canada and also contaminates grains with trichothecene mycotoxins. Very little is known about trichothecene diversity and population structure of the fungus from corn in Ontario, central Canada. Trichothecene genotypes of F. graminearum isolated from corn (n = 452) and wheat (n = 110) from 2010 to 2012 were identified. All the isolates were deoxynivalenol (DON) type. About 96% of corn isolates and 98% of wheat isolates were 15‐acetyl deoxynivalenol (15ADON) type. The fungal population structures from corn (n = 313) and wheat (n = 73) were compared using 10 variable number tandem repeat (VNTR) markers. The fungal populations and subpopulations categorized based on host, cultivar groups, years and geography showed high gene (H = 0.818–0.928) and genotypic (GD = 0.999–1.00) diversity. Gene flow was also high between corn and wheat population pairs (Nm = 8.212), and subpopulation pairs within corn (Nm = 7.13–23.614) or wheat (Nm = 19.483) populations. Phylogenetic analysis revealed that isolates from both hosts were F. graminearum clade 7. These findings provide baseline data on 3‐acetyl deoxynivalenol (3ADON) and 15ADON profiles of F. graminearum isolates from corn in Canada and are useful in evaluating mycotoxin contamination risks in corn and wheat grains. Understanding the fungal genetic structure will assist evaluation and development of resistant cultivars/germplasm for FHB on wheat and GER on corn.
Foreign Direct Investment and Domestic Child Labor
Authors: Chaudhuri Sarbajit , Dwibedi Jayanta Kumar 
Published: May 2016

AbstractEmpirical evidence suggests that use of child labor as domestic help has increased significantly in recent years although the overall incidence of child labor across the globe has declined satisfactorily. This should draw the attention of economists and policymakers because domestic child labor is considered as exploitative and in many cases hazardous. This paper purports to explain this apparently perplexing finding theoretically in terms of a three‐sector general equilibrium model with a nontraded sector where only child labor is used to render services to the richer section of the society. The analysis shows how FDI‐led economic growth increases the size of the services sector although it lowers the overall incidence of child labor in the economy and improves the welfare of the poor families that supply child labor. Finally, a composite policy has been recommended that can deal with all three aspects favorably.
Examining the Export Wage Premium in Developing Countries
Authors: Brambilla Irene , Depetris Chauvin Nicolas , Porto Guido 
Published: May 2016

AbstractThere are arguably potential wage gains from exports in developing countries. Export markets bring about opportunities for firms and successful exporting firms translate some of the benefits of exports to workers via employment and wage premia. Using comparable data for 61 developing and low‐income countries, we document the prevalence of the export wage premia worldwide. With an extensive literature review, we identify four major drivers of the wage premia: exporting firms hire more skilled workers, utilize more sophisticated machines, buy higher quality material inputs and are more productive than non‐exporting firms. Our empirical analysis confirms the worldwide prevalence of these mechanisms and, furthermore, establishes a strong link to the estimated wage premia.
Fluvial to tidal transition in proximal, mixed tide‐influenced and wave‐influenced deltaic deposits: Cretaceous lower Sego Sandstone, Utah, USA
Authors: van Cappelle Marijn , Stukins Stephen , Hampson Gary J. , Johnson Howard D. 
Published: May 2016

AbstractFacies models for regressive, tide‐influenced deltaic systems are under‐represented in the literature compared with their fluvial‐dominated and wave‐dominated counterparts. Here, a facies model is presented of the mixed, tide‐influenced and wave‐influenced deltaic strata of the Sego Sandstone, which was deposited in the Western Interior Seaway of North America during the Late Cretaceous. Previous work on the Sego Sandstone has focused on the medial to distal parts of the outcrop belt where tides and waves interact. This study focuses on the proximal outcrop belt, in which fluvial and tidal processes interact. Five facies associations are recognized. Bioturbated mudstones (Facies Association 1) were deposited in an offshore environment and are gradationally overlain by hummocky cross‐stratified sandstones (Facies Association 2) deposited in a wave‐dominated lower shoreface environment. These facies associations are erosionally overlain by tide‐dominated cross‐bedded sandstones (Facies Association 4) interbedded with ripple cross‐laminated heterolithic sandstones (Facies Association 3) and channelized mudstones (Facies Association 5). Palaeocurrent directions derived from cross‐bedding indicate bidirectional currents which are flood‐dominated in the lower part of the studied interval and become increasingly ebb‐directed/fluvial‐directed upward. At the top of the succession, ebb‐dominated/fluvial‐dominated, high relief, narrow channel forms are present, which are interpreted as distributary channels. When distributary channels are abandoned they effectively become estuaries with landward sediment transport and fining trends. These estuaries have sandstones of Facies Association 4 at their mouth and fine landward through heterolithic sandstones of Facies Association 3 to channelized mudstones of Facies Association 5. Therefore, the complex distribution of relatively mud‐rich and sand‐rich deposits in the tide‐dominated part of the lower Sego Sandstone is attributed to the avulsion history of active fluvial distributaries, in response to a subtly expressed allogenic change in sediment supply and relative sea‐level controls and autocyclic delta lobe abandonment.
Risk of tuberculosis after lung transplantation: the value of pretransplant chest computed tomography and the impact of mTOR inhibitors and azathioprine use
Authors: Guirao‐Arrabal E. , Santos F. , Redel‐Montero J. , Vaquero J.M. , Cantisán S. , Vidal E. , Torre‐Giménez Á. , Rivero A. , Torre‐Cisneros J. 
Published: May 2016

AbstractBackgroundIt is necessary to determine the incidence and risk factors for tuberculosis (TB), as well as strategies to assess and treat latent tuberculosis infection (LTBI) in lung transplant recipients.MethodsA retrospective cohort study of 398 lung transplant recipients was performed. Episodes of TB were studied and the incidence rate was calculated. Logistic regression analysis was used to analyze specific variables as potential risk factors for TB.ResultsMedian follow‐up was 558 days (range 1–6636). Six cases (1.5%) of TB were documented in 398 transplant patients. The incidence density of TB was 406.3 cases/105 patient‐years (95% confidence interval [CI] 164.7–845), which is higher than in the general population (13.10 cases/105 person‐years). All cases occurred in the period 1993–2006, when the tuberculin skin test (TST) and treatment of LTBI in positive TST patients were not part of the protocol. Pretransplant computed tomography (CT) showed residual lesions in 50% of patients who developed TB, although the TST was negative and the chest radiograph was inconclusive. Multivariate analysis identified the presence of residual lesions in the pretransplant chest CT (odds ratio [OR] 11.5, 95% CI 1.9–69.1, P = 0.008), use of azathioprine (OR 10.6, 95% CI 1.1–99.1, P = 0.038), and use of everolimus (OR 6.7, 95% CI 1.1–39.8, P = 0.036) as independent risk factors for TB.ConclusionsResidual lesions in the pretransplant chest CTs and the use of azathioprine and mTOR inhibitors are associated with the risk of TB.
A unique presentation of acute liver failure from herpes simplex virus hepatitis
Authors: Gutierrez C. , Kebriaei P. , Turner K.A. , Yemelyanova A. , Ariza‐Heredia E.J. , Foo W.C. 
Published: May 2016

AbstractWe present the case of a patient, with history of myelodysplastic syndrome and recent bone marrow transplant, who developed fulminant liver failure secondary to herpes simplex virus (HSV) hepatitis. His presentation was unique, as findings of liver microabscesses on computed tomography scan have not been described previously in this patient population. Despite initial treatment with acyclovir, he continued to deteriorate, and later sensitivities found the HSV strain to be resistant to acyclovir. HSV hepatitis with secondary liver failure is rare and, without appropriate treatment, its mortality is >80%. Early suspicion and immediate therapy are the keys to improve patient survival.
Serologic screening of United States blood donors for Babesia microti using an investigational enzyme immunoassay
Authors: Levin Andrew E. , Williamson Phillip C. , Bloch Evan M. , Clifford Joan , Cyrus Sherri , Shaz Beth H. , Kessler Debra , Gorlin Jed , Erwin James L. , Krueger Neil X. , Williams Greg V. , Penezina Oksana , Telford Sam R. , Branda John A. , Krause Peter J. , Wormser Gary P. , Schotthoefer Anna M. , Fritsche Thomas R. , Busch Michael P. 
Published: May 2016

BACKGROUNDThe tick‐borne pathogen Babesia microti has become recognized as the leading infectious risk associated with blood transfusion in the United States, yet no Food and Drug Administration–licensed screening tests are currently available to mitigate this risk. The aim of this study was to evaluate the performance of an investigational enzyme immunoassay (EIA) for B. microti as a screening test applied to endemic and nonendemic blood donor populations.STUDY DESIGN AND METHODSThe study aimed to test 20,000 blood donors from areas of the United States considered endemic for B. microti and 10,000 donors from a nonendemic area with the investigational B. microti EIA. Repeat‐reactive samples were retested by polymerase chain reaction (PCR), blood smear, immunofluorescent assay (IFA), and immunoblot assay. In parallel, serum samples from symptomatic patients with confirmed babesiosis were tested by EIA, IFA, and immunoblot assays.RESULTSA total of 38 of 13,757 (0.28%) of the donors from New York, 7 of 4583 (0.15%) from Minnesota, and 11 of 8363 (0.13%) from New Mexico were found repeat reactive by EIA. Nine of the 56 EIA repeat‐reactive donors (eight from New York and one from Minnesota) were positive by PCR. The specificity of the assay in a nonendemic population was 99.93%. Among IFA‐positive clinical babesiosis patients, the sensitivity of the assay was 91.1%.CONCLUSIONThe B. microti EIA detected PCR‐positive, potentially infectious blood donors in an endemic population and exhibited high specificity among uninfected and unexposed individuals. The EIA promises to provide an effective tool for blood donor screening for B. microti in a format amenable to high‐throughput and cost‐effective screening.
Evaluation of the in vitro efficacy of hemodialysis, hemoperfusion, and the combined approach on the removal of metaldehyde from canine plasma
Authors: Mauser Elisabeth L. , Puschner Birgit , Reese Sven , Hartmann Katrin , Doerfelt René 
Published: May 2016

AbstractObjectiveTo evaluate the effect of hemodialysis, hemoperfusion, and a combined approach on the removal of metaldehyde from canine plasma.DesignIn vitro study.SettingUniversity veterinary teaching hospital laboratory.AnimalsNone.InterventionsNone.Measurements and Main ResultsMetaldehyde‐fortified canine plasma was prepared. Hemodialysis (HD), charcoal hemoperfusion (HP), and in‐series hemodialysis and charcoal hemoperfusion (HD/HP) were applied in triplicate to eliminate metaldehyde from plasma. Plasma samples were obtained before starting the procedure and subsequently after every processed total plasma volume until plasma had been processed 10 times. Plasma metaldehyde concentration was quantitatively assayed by gas chromatography‐mass spectrometry. Statistical analysis was performed using one‐way ANOVA, repeated measures ANOVA, and Bonferroni post hoc test, and by calculating the coefficient of variation from duplicate measurements, binomial distribution, and by Bland–Altman analysis. Statistically significant reduction in metaldehyde concentration was reached by all 3 techniques. Reduction of metaldehyde concentration of more than 95% was achieved after processing the plasma volume 4 times applying HD, 8 times applying HP, and 2 times applying HD/HP. Efficacy in reduction of metaldehyde concentration differed significantly between the 3 procedures (P< 0.001). In‐series hemodialysis and charcoal hemoperfusion was more effective in metaldehyde removal than HD (P= 0.003) and HP (P< 0.001), and HD was more effective than HP (P= 0.002).ConclusionsMetaldehyde was effectively removed by all applied extracorporeal blood purification techniques in vitro. However, the combination of both techniques was more effective than HD or HP alone. Further clinical studies are warranted to confirm therapeutic benefits in patients.
Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization?
Authors: McDaniel Larry S. , Swiatlo Edwin 
Published: May 2016

ABSTRACT

Streptococcus pneumoniae
remains an important human pathogen. For more than 100 years, there have been vaccine efforts to prevent pneumococcal infection. The pneumococcal conjugate vaccines have significantly reduced invasive disease. However, these vaccines have changed pneumococcal ecology within the human nasopharynx. We suggest that elimination of the pneumococcus from the human nasopharynx can have consequences that should be considered as the next generation of pneumococcal vaccines is developed.
Evaluation of the association between Hospital Survey on Patient Safety Culture (HSOPS) measures and catheter-associated infections: results of two national collaboratives
Authors: Meddings Jennifer , Reichert Heidi , Greene M Todd , Safdar Nasia , Krein Sarah L , Olmsted Russell N , Watson Sam R , Edson Barbara , Albert Lesher Mariana , Saint Sanjay 
Published: May 2016

BackgroundThe Agency for Healthcare Research and Quality (AHRQ) has funded national collaboratives using the Comprehensive Unit-based Safety Program to reduce rates of two catheter-associated infections—central-line-associated bloodstream infection (CLABSI) and catheter-associated urinary tract infection (CAUTI), using evidence-based intervention bundles to improve technical aspects of care and socioadaptive approaches to foster a culture of safety.ObjectiveExamine the association between hospital units' results for the Hospital Survey on Patient Safety Culture (HSOPS) and catheter-associated infection rates.MethodsWe analysed data from two prospective cohort studies from acute-care intensive care units (ICUs) and non-ICUs participating in the AHRQ CLABSI and CAUTI collaboratives. National Healthcare Safety Network catheter-associated infections per 1000 catheter-days were collected at baseline and quarterly postimplementation. The HSOPS was collected at baseline and again 1 year later. Infection rates were modelled using multilevel negative binomial models as a function of HSOPS components over time, adjusted for hospital-level characteristics.Results1821 units from 1079 hospitals (CLABSI) and 1576 units from 949 hospitals (CAUTI) were included. Among responding units, infection rates declined over the project periods (by 47% for CLABSI, by 23% for CAUTI, unadjusted). No significant associations were found between CLABSI or CAUTI rates and HSOPS measures at baseline or over time.ConclusionsWe found no association between results of the HSOPS and catheter-associated infection rates when measured at baseline and postintervention in two successful large national collaboratives focused on prevention of CLABSI and CAUTI. These results suggest that it may be possible to improve CLABSI and CAUTI rates without making significant changes in safety culture, particularly as measured by instruments like HSOPS.
Endovascular treatment for ruptured and unruptured vertebral artery dissecting aneurysms: a meta-analysis
Authors: Guan Jian , Li Guilin , Kong Xiangyi , He Chuan , Long Jianwu , Qin Hao , Zhang Hongqi , Wang Renzhi 
Published: May 2016

BackgroundDifferent endovascular modalities have been applied to the treatment of vertebral artery dissecting aneurysms, the most commonly used being internal trapping and stent-assisted coiling, although the ideal treatment remains controversial.ObjectiveTo perform a meta-analysis to study clinical outcomes of patients with vertebral artery dissecting aneurysms who were treated with internal trapping or stent-assisted coiling.Materials and methodsWe conducted a meta-analysis of eight retrospective studies that compared internal trapping with stent-assisted coiling for the treatment of vertebral artery dissecting aneurysms. The primary outcomes of this study were immediate occlusion, long-term occlusion, good outcome ratio, perioperative mortality, and angiographic recurrence. Subgroup analyses were conducted of patients with ruptured versus unruptured vertebral artery dissecting aneurysms.ResultsEight studies comprising a total of 188 patients were included in the analysis. For ruptured cases, in comparison with stent-assisted coiling groups, the patients treated with trapping techniques had a higher rate of immediate postoperative occlusion (OR=0.165; 95% CI 0.067 to 0.405; p<0.01), although there was no significant difference in long-term occlusion (OR=1.059; 95% CI 0.033 to 34.121; p=0.974), good clinical outcome rates, recurrence rates, and perioperative mortality. For unruptured cases, patients in the trapping groups also had higher immediate occlusion rates than those who underwent stent-assisted coiling (OR=0.175; 95% CI 0.043 to 0.709; p=0.015), while rates of both recurrence and good clinical outcome were similar between the two groups.ConclusionsBoth internal trapping and stent-assisted coiling are technically feasible for ruptured vertebral artery dissecting aneurysms, with high rates of good long-term neurologic outcomes and low recurrence and mortality rates. For unruptured aneurysms, conservative treatment is recommended. When a posterior inferior cerebellar artery (PICA) origin is involved, bypass surgery or vertebral artery-to-PICA stent placement plus coil embolization should be considered.
Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Authors: Grossman Moran , Ben-Chetrit Nir , Zhuravlev Alina , Afik Ran , Bassat Elad , Solomonov Inna , Yarden Yosef , Sagi Irit 
Published: May 2016

Abstract
Abnormal architectures of collagen fibers in the extracellular matrix (ECM) are hallmarks of many invasive diseases, including cancer. Targeting specific stages of collagen assembly in vivo presents a great challenge due to the involvement of various crosslinking enzymes in the multistep, hierarchical process of ECM build-up. Using advanced microscopic tools, we monitored stages of fibrillary collagen assembly in a native fibroblast-derived 3D matrix system and identified anti-lysyl oxidase-like 2 (LOXL2) antibodies that alter the natural alignment and width of endogenic fibrillary collagens without affecting ECM composition. The disrupted collagen morphologies interfered with the adhesion and invasion properties of human breast cancer cells. Treatment of mice bearing breast cancer xenografts with the inhibitory antibodies resulted in disruption of the tumorigenic collagen superstructure and in reduction of primary tumor growth. Our approach could serve as a general methodology to identify novel therapeutics targeting fibrillary protein organization to treat ECM-associated pathologies. Cancer Res; 76(14); 4249–58. ©2016 AACR.