bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le terme « dharma » (tib. chos) et son applicabilité dans le contexte du Dharmadharmatāvibhāga, texte bouddhique de l’Inde du ive siècle
Authors: Denis Diane 
Published: November 2017

Cet article a pour objectif d’examiner le terme dharma (tib. chos) tel qu’utilisé dans un texte bouddhique de l’Inde du ive siècle, le Dharmadharmatāvibhāga. Les difficultés de traduction qu’ont eues les spécialistes jusqu’ici sont le symptôme d’un problème plus profond touchant à l’interprétation de cette notion ainsi qu’à sa fonction. On est ici devant un problème dans lequel la réflexion philosophique est en elle-même une pratique.
L’abandon chez Charles de Foucauld et Madame Guyon
Authors: Tanguay Félix 
Published: November 2017

Le présent article s’interroge sur la notion d’abandon mise de l’avant dans plusieurs ouvrages de spiritualité. Plus précisément, il se penche sur l’acception du terme « abandon » chez deux mystiques chrétiens catholiques qui ont marqué l’histoire, soit Charles de Foucauld (1858-1916) et Madame Guyon (1648-1717). Par le biais de deux textes fondamentaux de ces deux auteurs et selon une grille d’analyse en trois volets (l’abandon selon la relation à soi, à Dieu et à l’autre), l’article permet de montrer que, loin d’être évidente, la notion d’abandon varie selon plusieurs facteurs et ne saurait se réduire à une seule définition. Par exemple, alors que, chez Foucauld, l’abandon tend à se traduire par une intense pratique extérieure et un appel à suivre l’exemple de Jésus, chez Guyon, l’abandon renvoie plutôt à une expérience intérieure et une volonté de partager cette expérience. La recherche permet également de déceler un trait d’union historique entre les deux mystiques, c’est-à-dire le livre L’abandon à la Providence divine. En conclusion, l’article suggère une piste de réflexion sur la notion contemporaine de l’abandon chez Alexandre Jollien.
Recalling the Past in Postcolonial Drama: From Counter-History to Sociopolitical Redress
Authors: Khawaldeh Imad M. , Bani-Khair Baker , Al-Khawaldeh Nisreen 
Published: November 2017

Through examining the texts of Ama Ata Aidoo's play Anowa (1970), Jack Davis's play Kullark (or Home)(1979), and Dennis Scott's play An Echo in the Bone (1974); this paper shows how postcolonial drama functions as an effective means for exploring occluded pre-colonial and colonial periods through constructing alternative histories that both refract the official accounts of the colonialist history and redress or treat contemporary societal and political exclusions. To this end, the researchers argue that the counter-discursive/ counter-historical task of many historical postcolonial dramas is to reconstruct their histories in a way that confirms the essential socio-political function of such plays. In this sense, a conscious linkage is being made between contemporary post-colonial communities and their past pre-colonial and colonial histories.
Mechanisms of oat (Avena sativaL.) acclimation to phosphate deficiency
Authors: Żebrowska Ewa , Milewska Marta , Ciereszko Iwona 
Published: November 2017

BackgroundDeficiency of available forms of phosphorus is common in most soils and causes reduction of crop plants growth and yield. Recently, model plants responses to phosphate (Pi) deficiency have been intensively studied. However, acclimation mechanisms of cereals like oat (Avena sativaL.), to low Pi stress remains not fully understood. Oat plants have been usually cultured on poor soils, with a low nutrient content, but their responses to such conditions are not well known, therefore the main goal of the study was to investigate the mechanisms that enable oat plants to grow under low Pi conditions.MethodsFour oat cultivars (A. sativa, cv. Arab, Krezus, Rajtar and Szakal) were grown for three weeks in a nutrient media with various P sources: inorganic—KH2PO4(control), organic—phytate (PA) and with no phosphate (−P). The effects of Pi deficiency on the level of P, oat growth parameters, intensity of photosynthesis, plant productivity, root exudation ability, localization, activity and isoforms of acid phosphatases, enzymes involved in Pi mobilization, were estimated. In addition, the effect of mycorrhization on plant growth was also observed.ResultsAll studied oat cultivars grown on Pi-deficient media had significantly decreased Pi content in the tissues. Pi deficiency caused inhibition of shoot growth, but generally it did not affect root elongation; root diameter was decreased, root/shoot ratios increased, whereas PA plants showed a similar growth to control. Photosynthesis rate and productivity parameters decreased under low Pi nutrition, however, sugar content generally increased. Studied oat cultivars did not respond to low Piviaincreased exudation of carboxylates from the roots, as pH changes in the growth media were not observed. Pi starvation significantly increased the activity of extracellular and intracellular acid phosphatases (APases) in comparison to the control plants. Three major APase isoforms were detected in oat tissues and the isoform pattern was similar in all studied conditions, usually with a higher level of one of the isoforms under Pi starvation. Generally no significant effects of mycorrhizal colonization on growth of oat cultivars were observed.DiscussionWe postulated that acid phosphatases played the most important role in oat cultivars acclimation to Pi deficiency, especially extracellular enzymes involved in Pi acquisition from soil organic P esters. These APases are mainly located in the epidermis of young roots, and may be released to the rhizosphere. On the other hand, intracellular APases could be involved in fast Pi remobilization from internal sources. Our study showed that oat, in contrast to other plants, can use phytates as the sole source of P. The studied oat cultivars demonstrated similar acclimation mechanisms to Pi deficiency, however, depending on stress level, they can use different pools of acid phosphatases.
Scaldiporia vandokkumi, a new pontoporiid (Mammalia, Cetacea, Odontoceti) from the Late Miocene to earliest Pliocene of the Westerschelde estuary (The Netherlands)
Authors: Post Klaas , Louwye Stephen , Lambert Olivier 
Published: November 2017

BackgroundThe family Pontoporiidae (Cetacea, Odontoceti, Inioidea) is currently represented in our oceans by just one species of diminutive dolphin (Pontoporia blainvillei,franciscana). AlthoughP. blainvilleiis limited to coastal waters of the South Atlantic along Brazil, Uruguay and Argentina, multiple Miocene and Pliocene fossils indicate the past presence of members of the family in the South Atlantic, South Paciifc and North Atlantic oceans. Our comprehension of the origin and diversity of this clade and of the relationships of its members with other inioids is hampered by the fact that part of the described fossil specimens, especially from the North Atlantic realm, are cranial fragments often associated to limited stratigraphic information.MethodsBased on an almost complete fossil cranium of pontoporiid from the Westerschelde estuary, The Netherlands, whose preservation allows for detailed morphological observations, we describe a new genus and species. The latter is compared to other pontoporiids, as well as a few non-pontoporiid inioids. A phylogenetic analysis is performed to investigate the relationship of S. vandokkumiwith the best-known extinct and extant inioids. Palynological analysis of the sediment associated to the holotype is used to assess its geological age.Results and discussionThe new genus and speciesScaldiporia vandokkumiis characterized among others by greatly thickened premaxillary eminences reaching the level of the antorbital notch. Palynologically dated from the late Tortonian—earliest Zanclean (7.6–5 Ma, Late Miocene—earliest Pliocene), this new pontoporiid confirms the surprising past diversity of marine inioids in the North Atlantic area. Finally the content of the pontoporiid subfamily Brachydelphininae is briefly discussed.
A retrospective chart review of opioid represcribing following nonfatal overdose at a Veterans Affairs hospital
Authors: Boyle Julia , Clement Cassandra , Atherton Abril , Stock Christopher 
Published: November 2017

Abstract

Introduction:
Opioid-related overdoses have risen despite extensive media coverage and apparent awareness of this public health crisis. Emergency department visits related to opioid use nearly tripled from 2004 to 2011. Patients with mental illness are more likely to be prescribed opioids and have higher rates of overdose. This retrospective chart review sought to determine if opioid represcribing occurred after patients were treated for a nonfatal opioid overdose (NFO) at a Veterans Affairs hospital.

Methods:
Patients who experienced an NFO between 2009 and 2013 were included and charts reviewed until January 1, 2016. Review of the electronic medical record (EMR) was performed to determine if and when opioids were again prescribed after NFO.

Results:
Fifty-six veterans met the inclusion criteria. A new opioid prescription was issued to 82% of patients within 3 months following the index NFO date. The average daily morphine equivalent dose prescribed before (122 mg) and after (120 mg) NFO did not differ. A subsequent opioid overdose event occurred in 25% of patients, and there was 1 fatal event. Only 1 patient had medication overdose on the problem list of their EMR.

Discussion:
Despite experiencing NFO, veterans continued to be prescribed opioids without significant changes in the drug or dose; some experienced repeated overdose events, possibly due to poor communication and documentation of NFO. Pharmacists can play a key role in clinical interventions and education of patients and prescribers.
Quality of life and chronic renal failure Qualidade de vida e insuficiência renal crônica
Authors: Weykamp Juliana marques , Nunes Márcia Helena Baltassare , Cecagno Diana , De siqueira Hedi crecencia heckler 
Published: November 2017

Objetivo: Conhecer a produção cientifica, no período de 2009 a2015, a respeito da qualidade de vida do portador de insuficiência renal crônica. Método: Revisão integrativa realizada via online na Biblioteca Virtual em Saúde na base de dados da Literatura Latino-Americana e do Caribe em Ciências da Saúde, respeitando os aspectos éticos em relação as autorias dos artigos. A amostra constituiu-se de 14 artigos científicos completos. Resultados e discussão: Apesar da Insuficiência Renal Crônica estar adquirindo importância no rol das doenças crônicas existe um número reduzido de artigos relacionados à temática, dentre estes, o destaque é para usuários em hemodiálise e, independente da abordagem, os estudos analisados evidenciam que várias dimensões do portador com insuficiência renal crônica são afetadas e essas influenciam na sua qualidade de vida. Conclusão: Recomenda-se novos estudos a respeito da qualidade de vida dos usuários em modalidades de tratamento como a diálise peritoneal e transplante renal.
Significance of Northeast‐Trending Features in Canada Basin, Arctic Ocean
Authors: Hutchinson D. R. , Jackson H. R. , Houseknecht D. W. , Li Q. , Shimeld J. W. , Mosher D. C. , Chian D. , Saltus R. W. , Oakey G. N. 
Published: November 2017

AbstractSynthesis of seismic velocity, potential field, and geological data from Canada Basin and its surrounding continental margins suggests that a northeast‐trending structural fabric has influenced the origin, evolution, and current tectonics of the basin. This structural fabric has a crustal origin, based on the persistence of these trends in upward continuation of total magnetic intensity data and vertical derivative analysis of free‐air gravity data. Three subparallel northeast‐trending features are described. Northwind Escarpment, bounding the east side of the Chukchi Borderland, extends ∼600 km and separates continental crust of Northwind Ridge from high‐velocity transitional crust in Canada Basin. A second, shorter northeast‐trending zone extends ∼300 km in northern Canada Basin and separates inferred continental crust of Sever Spur from magmatically intruded crust of the High Arctic Large Igneous Province. A third northeast‐trending feature, here called the Alaska‐Prince Patrick magnetic lineament (APPL) is inferred from magnetic data and its larger regional geologic setting. Analysis of these three features suggests strike slip or transtensional deformation played a role in the opening of Canada Basin. These features can be explained by initial Jurassic‐Early Cretaceous strike slip deformation (phase 1) followed in the Early Cretaceous (∼134 to ∼124 Ma) by rotation of Arctic Alaska with seafloor spreading orthogonal to the fossil spreading axis preserved in the central Canada Basin (phase 2). In this model, the Chukchi Borderland is part of Arctic Alaska.
Influence of Exsolved Volatiles on Reheating Silicic Magmas by Recharge and Consequences for Eruptive Style at Volcán Quizapu (Chile)
Authors: Degruyter W. , Huber C. , Bachmann O. , Cooper K. M. , Kent A. J. R. 
Published: November 2017

AbstractThe two most recent eruptions of Volcán Quizapu (southern Andes, Chile), only 85 years apart, were both triggered by magma recharge and extruded the same volume (about 5 km3) of the same volatile‐rich dacitic magma, but showed a remarkable shift from effusive (1846–1847) to explosive (1932) behavior. We demonstrate, using a newly developed model, that the presence or absence of an exsolved volatile phase in the reservoir strongly influences its mechanical and thermal response to new inputs of magma. We propose that, prior to the 1846–1847 effusive eruption, gas bubbles damped the build‐up of excess pressure and allowed recharge of a significant volume of magma before triggering the 1846–1847 eruption. The strong temperature increase that resulted enhanced syneruptive outgassing leading to an effusive eruption. In contrast, during the repose period between the 1847 and 1932 eruptions, new recharges found a much less compressible host reservoir as the exsolved gas phase was largely removed in response to the prior eruption, yielding rapid pressurization, minor reheating, and comparatively less syneruptive outgassing. The combination of these effects culminated in an explosive eruption.
The Geologic Exploration of the Bagnold Dune Field at Gale Crater by the Curiosity Rover
Authors: Chojnacki Matthew , Fenton Lori K. 
Published: November 2017

AbstractThe Mars Science Laboratory rover Curiosity engaged in a monthlong campaign investigating the Bagnold dune field in Gale crater. What represents the first in situ investigation of a dune field on another planet has resulted in a number of discoveries. Collectively, the Curiosity rover team has compiled the most comprehensive survey of any extraterrestrial aeolian system visited to date with results that yield important insights into a number of processes, including sediment transport, bed form morphology and structure, chemical and physical composition of aeolian sand, and wind regime characteristics. These findings and more are provided in detail by the JGR‐Planets Special Issue Curiosity's Bagnold Dunes Campaign, Phase I.
Photoredox Catalysis in C–S Bond Construction: Recent Progress in Photo‐Catalyzed Formation of Sulfones and Sulfoxides
Authors: Zhu Jie , Yang Wen‐Chao , Wang Xiao‐dong , Wu Lei 
Published: November 2017

AbstractThe emergence of radical chemistry as well as green chemistry in organic synthesis has initiated an interest in photochemistry over the past decade. With catalytic amounts of photoredox catalysts under light irradiation, high active radical species are produced, which could trigger the subsequent organic transformations smoothly. Among the various photoredox reactions, photo‐catalytic C–S bond formation continues to thrive, as the C–S bond is indispensable in many important biological and pharmaceutical compounds. Great attention has been devoted to this area as illustrated by the series of papers on sulfone and sulfoxide skeleton synthesis under irradiation published in the past years. This review summarizing the recent advances in photo‐catalyzed sulfones and sulfoxide formation is arranged by reaction type together with the sulfur source covering sulfonylation and sulfinylation reactions. It is intended to provide readers with a comprehensive understanding of photo‐catalytic C‐S bond formation and offer help for future research.magnified image
Demographics and patient characteristics of 1209 patients with Gaucher disease: Descriptive analysis from the Gaucher Outcome Survey (GOS)
Authors: Zimran Ari , Belmatoug Nadia , Bembi Bruno , Deegan Patrick , Elstein Deborah , Fernandez‐Sasso Diego , Giraldo Pilar , Goker‐Alpan Ozlem , Lau Heather , Lukina Elena , Panahloo Zoya , Schwartz Ida Vanessa D. ,   on behalf of the GOS Study group
Published: November 2017

AbstractThe Gaucher Outcome Survey (GOS) is an international Gaucher disease (GD) registry established in 2010 for patients with a confirmed GD diagnosis, regardless of GD type or treatment status, designed to evaluate the safety and long‐term effectiveness of velaglucerase alfa and other GD‐related treatments. As of February 25, 2017, 1209 patients had enrolled, the majority from Israel (44.3%) and the US (31.4%). Median age at GOS entry was 40.4 years, 44.1% were male, and 13.3% had undergone a total splenectomy. Most patients had type 1 GD (91.5%) and were of Ashkenazi Jewish ethnicity (55.8%). N370S/N370S was the most prevalent genotype, accounting for 44.2% of genotype‐confirmed individuals (n = 847); however, there was considerable variation between countries. A total of 887 (73.4%) patients had received ≥1 GD‐specific treatment at any time, most commonly imiglucerase (n = 587), velaglucerase alfa (n = 507), and alglucerase (n = 102). Hematological and visceral findings at the time of GOS entry were close to normal for most patients, probably a result of previous treatment; however, spleen volume of patients in Israel was almost double that of patients elsewhere (7.2 multiples of normal [MN] vs. 2.7, 2.9 and 4.9 MN in the US, UK and rest of world), which may be explained by a greater disease severity in this cohort. This analysis aimed to provide an overview of GOS and present baseline demographic and disease characteristics of participating patients to help improve the understanding of the natural history of GD and inform the overall management of patients with the disease.
Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α‐granules
Authors: Favier Marie , Bordet Jean‐Claude , Favier Remi , Gkalea Vasiliki , Pillois Xavier , Rameau Philippe , Debili Najet , Alessi Marie‐Christine , Nurden Paquita , Raslova Hana , Nurden Alan 
Published: November 2017

AbstractRare gain‐of‐function mutations within the ITGA2B or ITGB3 genes have been recognized to cause macrothrombocytopenia (MTP). Here we report three new families with autosomal dominant (AD) MTP, two harboring the same mutation of ITGA2B, αIIbR995W, and a third family with an ITGB3 mutation, β3D723H. In silico analysis shows how the two mutated amino acids directly modify the salt bridge linking the intra‐cytoplasmic part of αIIb to β3 of the integrin αIIbβ3. For all affected patients, the bleeding syndrome and MTP was mild to moderate. Platelet aggregation tended to be reduced but not absent. Electron microscopy associated with a morphometric analysis revealed large round platelets; a feature being the presence of abnormal large α‐granules with some giant forms showing signs of fusion. Analysis of the maturation and development of megakaryocytes reveal no defect in their early maturation but abnormal proplatelet formation was observed with increased size of the tips. Interestingly, this study revealed that in addition to the classical phenotype of patients with αIIbβ3 intracytoplasmic mutations there is an abnormal maturation of α‐granules. It is now necessary to determine if this feature is a characteristic of all mutations disturbing the αIIb R995/β3 D723 salt bridge.
Brief communication: A re‐evaluation of the health index of southern Brazilian shellmound populations
Authors: Hubbe Mark , Green Madelyn K. , Cheverko Colleen M. , Neves Walter A. 
Published: November 2017

AbstractObjectivesThe southern Brazilian shellmounds provide archaeological evidence of prolonged human activity in the coast from approximately 6000 to 1000 BP. Shellmound building populations exploited the rich coastal estuarine zones, and the human remains recovered from them are important sources of information on health and overall lifestyle of these mid‐Holocene groups. Therefore, they were included in the Western Hemisphere Global History of Health project. The shellmounds contribute the highest Health Index in the Western Hemisphere, but these conclusions are based on collections that exclude postcranial remains. Here, we reconstruct the Health Index for one specific shellmound using both cranial and postcranial remains to determine whether the initial studies might misrepresent the relative health of the Brazilian shellmound builders.Materials and methodsThe Health Index was calculated for a sample of 18 complete skeletons recovered from the shellmound Porto do Rio Vermelho 02 (Santa Catarina Island, Brazil). The Heath Index was calculated with and without postcranial markers and the results are compared with the Western Hemisphere Global History of Health data.ResultsThe Health Index for Porto do Rio Vermelho 02 is lower than the reported average for American series in the Western Hemisphere Global History of Health Project and considerably lower than the original index reported for Brazilian shellmounds. This discrepancy is due to an increased prevalence of infectious disease and low stature.ConclusionsAlthough the Health Index remains a useful comparison statistic, re‐evaluation of fragmentary skeletal remains demonstrates the need for caution when applying it to incomplete skeletal series.
Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
Authors: Saleh Mostafa F. M. , Saunthararajah Yogen 
Published: November 2017

Key Clinical MessagePyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat underlying myeloid malignancy causing PG, to thereby produce safe and effective resolution of extensive PG.
Cobalt‐Catalyzed Annulation Reactions via C−H Bond Activation
Authors: Prakash Sekar , Kuppusamy Ramajayam , Cheng Chien‐Hong 
Published: November 2017

AbstractConsiderable research attention has been directed towards the use of first‐row transition metals in organic synthesis. The more abundant, and less expensive cobalt is considered to be an effective alternative for expensive second and third‐row noble metals, especially in C−H bond functionalization reactions. In this Minireview, we will summarize the features, and recent achievements of the Co‐catalyzed directing group assisted C−H activation/cyclization reactions and their mechanistic insights.