bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Approaches for the MS-Based Detection of Food Allergens: High Resolution, MS3, and Beyond
Authors: Brockmeyer Jens 
Published: December 2017

Abstract
The prevalence of allergic reactions to food is believed to be increasing in industrialized countries worldwide. One of the major tasks in risk management is, therefore, the analytical surveillance of allergen contamination in food and targeted proteomics using MS, which is of hugely growing interest due to its specificity and sensitivity and the possibility to analyze multiple allergens in parallel. Though approximately 200 different foods have been described as having the potential to elicit allergic reactions, current regional labeling requirements are focused on the 5–14 priority allergens that elicit the vast majority of severe reactions or that pose a risk as hidden allergens in food production. MS-based detection methods have been published for the majority of priority allergens, and this review provides an overview of the different methodological approaches, namely multiple-reaction monitoring-, high-resolution MS-, and triple-stage MS-based methods. In addition, requirements for the identification and validation of specific marker peptides and the influence of thermal processing and structural heterogeneity of allergens are discussed.
Simultaneous Analysis of Multiple Allergens in Food Products by LC-MS/MS
Authors: New Lee Sun , Schreiber Andre , Stahl-Zeng Jianru , Liu Hua-Fen 
Published: December 2017

Abstract
There is currently no cure for food allergies, and sufferers can only rely on the correct labeling of foods to avoid allergens. Hence, it is important that analytical methods are sensitive and accurate enough to screen for the presence of multiple allergens in food products. In this study, we developed an LC-tandem MS method that is able to simultaneously screen or quantify the signature tryptic peptides of multiple allergen commodities. This method is capable of screening and identifying egg white, skim milk, peanut, soy, and tree nuts (almond, Brazil nut, cashew, hazelnut, pecan, pine nut, pistachio, and walnut) at a detection limit of 10 ppm in incurred bread and cookies. It was further tested for the quantitative analysis of whole-egg, whole-milk, peanut butter, and hazelnut commodities, which are incurred or spiked into selected food matrixes as defined in AOAC INTERNATIONAL Standard Method Performance Requirement (SMPR®) 2016.002. The method demonstrated excellent sensitivity with a Method quantitative limit of 3 ppm for whole egg and 10 ppm for the remaining three allergen commodities. It also demonstrated good recovery (60-119%) and repeatability (RSDr &lt;20%), with an analytical range of 10–1000 ppm for each allergen commodity and was able to meet the minimum performance requirements of the SMPR.
Almond or Mahaleb? Orthogonal Allergen Analysis During a Live Incident Investigation by ELISA, Molecular Biology, and Protein Mass Spectrometry
Authors: Walker Michael J , Burns Malcolm , Quaglia Milena , Nixon Gavin , Hopley Christopher J , Gray Kirstin M , Moore Victoria , Singh Malvinder , Cowen Simon 
Published: December 2017

Abstract
It is now well known that an incident investigated in the United Kingdom in 2015 of cumin alleged to be contaminated with almond, a risk for people with almond allergy, was caused by the Prunus species, Prunus mahaleb. In the United Kingdom, the Government Chemist offers a route of technical appeal from official findings in the food control system. Findings of almond in two official samples, cumin and paprika, which had prompted action to exclude the consignments from the food chain, were so referred. Herein are described the approaches deployed to resolve the analytical issues during the investigation of the incidents. The cross-reactivity of ELISA to Prunus species was confirmed, and although this is useful in screening for the genus, orthogonal techniques are required to identify the species and confirm its presence. Two novel PCR assays were developed: one specific for P. mahaleb and the other a screening method capable of identifying common Prunus DNA. Peptides unique to almond and mahaleb were identified, permitting LC-tandem MS and criteria were developed for peptide identification to forensic standards. This work enables a staged approach to be taken to any future incident thought to involve Prunus species and provides a template for the investigation of similar incidents.
Closed city la primavera
Authors: Rodríguez González Sylvia Cristina 
Published: December 2017

En la actualidad, el proceso de crecimiento urbano ante la globalización va ligado al
fenómeno de expansión urbana, como primer proceso de la tendencia expansióndensificación,
la cual se distingue por sus manifestaciones en la problemática urbana.
Esta tendencia estimula el cambio morfológico de las ciudades, especialmente por nuevos
desarrollos habitacionales de tipo cerrado, donde la delimitación del conjunto es la muralla. El
fenómeno de expansión urbana, a su vez, se distingue por elementos estructurales de la
ciudad como vías rápidas, y por el énfasis en las dinámicas de articulación del territorio por
nuevas urbanizaciones.
Como el caso La Primavera, el cual constituye un elemento autónomo a la ciudad de Culiacán,
Sinaloa, en México, conformando una ciudad urbanizada de tipo cerrada, con gran extensión,
pretensiones plasmadas en el proyecto en el que se plantea una multifuncionalidad dirigida a
satisfacer las necesidades de estratos altos de la comunidad.
Nowadays, the process of urban growth, in the globalization context, is linked to the phenomenon of urban expansion, by means of two processes: urban densification and urban expansion.

This trend incentivizes the morphological change of cities, especially motivated for housing developments in the gated communities’ format, where the delimitation border is the wall. The phenomenon of urban sprawl is characterized by city structural elements as highways, which emphasize the articulation dynamics of new land developments.
This is the case of “La Primavera”, which is an independent city in the city of Culiacan (in the Mexican State of Sinaloa). La Primavera is a closed city, which embraces a huge land extension; this project supposedly “multifunctional” is clearly oriented to the wealthiest segment of Culiacan’s society.
En l’actualitat, el procés de creixement urbà front la globalització va lligat al fenomen d’expansió urbana, com primer pas de la tendència expansió-densificació, la qual es distingeix per les seves manifestacions en la problemàtica urbana.

Aquesta tendència estimula el canvi morfològic de les ciutats, especialment per nous desenvolupaments habitacionals de tipus tancat, on la delimitació del conjunt es una muralla. El fenomen d’expansió urbana, al mateix temps, es distingeix per elements estructurals de la ciutat com vies ràpides, i per l’èmfasi en les dinàmiques d’articulació del territori per noves urbanitzacions.

Com el cas La Primavera, el qual constitueix un element autònom a la ciutat de Culiacán, Sinaloa, a Mèxic, conformant una ciutat urbanitzada de tipus tancada, amb gran extensió, requeriments continguts en el projecte en el que es planteja una multi funcionalitat dirigida a satisfer les necessitats d’alts estrats de la comunitat.
Devenir-plante : enlacements vivants en Océan Indien et en Amazonie
Authors: Laplante Julie 
Published: December 2017

Percevoir un médicament, un remède ou une drogue comme un objet pouvant nuire ou guérir selon une logique causale est possible selon un positionnement de l’extérieur. Si l’on se place au milieu des choses ou entre l’humain et le non-humain dans l’agencement-vie qui émerge entre les deux, il n’y a plus ni objet, ni sujet, mais un devenir. Voilà le lieu qu’occupent maintes chamanes et guérisseuses pour mieux connaître comment guérir avec les plantes, certaines de ces plantes étant communément nommées « drogue » ou « psychotrope », lorsque reconnues selon leurs propriétés biopharmaceutiques ou biomoléculaires. Dans cet article, je vise à montrer en quoi l’approche horizontale de guérisseurs en océan Indien et en Amazonie se comprend mieux par une approche phénoménologique rhizomique que par une approche généalogique de l’arborescence sur laquelle repose en grande partie l’approche scientifique actuelle. Trois études de cas démontrent respectivement en quoi devenir-plante se fait par le mouvement-repos, le rêve et l’affect. L’approche phénoménologique rhizomique en anthropologie proposée emprunte en partie à Deleuze et Guattari (1980) et permet de mieux comprendre comment il est possible d’entretenir des relations fructueuses avec les plantes. Une telle approche amène à privilégier un savoir obtenu par proximité, plutôt qu’à poser un regard de la distance typique du laboratoire qui extrapole la plante de ses contextes, voire d’elle-même, et qui s’intéresse le plus souvent à l’une des molécules de la plante plutôt qu’à ses synergies activées dans-la-vie.
L’internationalisation des firmes multinationales technologiques chinoises
Authors: Arès Mathieu , Huang Ping 
Published: December 2017

La révolution technologique est au coeur du redéploiement de l’économie mondiale et de son recentrage en Asie, la Chine en particulier se présentant désormais comme « l’atelier du monde ». L’autonomie technologie et le contrôle des chaînes de valeur sont au centre de la nouvelle géopolitique mondiale. L’étude de cas de Lenovo, devenu en trente ans le principal fabricant d’ordinateurs personnels (pc), met en relief les efforts chinois pour gravir les échelons de l’intensité technologique.
Glycosaminoglycan and Proteoglycan‐Based Biomaterials: Current Trends and Future Perspectives
Authors: Rnjak‐Kovacina Jelena , Tang Fengying , Whitelock John M. , Lord Megan S. 
Published: December 2017

AbstractProteoglycans and their glycosaminoglycans (GAG) are essential for life as they are responsible for orchestrating many essential functions in development and tissue homeostasis, including biophysical properties and roles in cell signaling and extracellular matrix assembly. In an attempt to capture these biological functions, a range of biomaterials are designed to incorporate off‐the‐shelf GAGs, typically isolated from animal sources, for tissue engineering, drug delivery, and regenerative medicine applications. All GAGs, with the exception of hyaluronan, are present in the body covalently coupled to the protein core of proteoglycans, yet the incorporation of proteoglycans into biomaterials remains relatively unexplored. Proteoglycan‐based biomaterials are more likely to recapitulate the unique, tissue‐specific GAG profiles and native GAG presentation in human tissues. The protein core offers additional biological functionality, including cell, growth factor, and extracellular matrix binding domains, as well as sites for protein immobilization chemistries. Finally, proteoglycans can be recombinantly expressed in mammalian cells and thus offer genetic manipulation and metabolic engineering opportunities for control over the protein and GAG structures and functions. This Progress Report summarizes current developments in GAG‐based biomaterials and presents emerging research and future opportunities for the development of biomaterials that incorporate GAGs presented in their native proteoglycan form.
Child Maltreatment, Problem Behaviors, and Neighborhood Attainment
Authors: Chauhan Preeti , Schuck Amie M. , Widom Cathy Spatz 
Published: December 2017

AbstractUsing data from a prospective cohort design study of a group of children with documented histories of abuse and neglect (n = 908) and matched controls (n = 667), this paper examines whether problem behaviors (e.g., prostitution, crime, school problems, and homelessness) in young adulthood explain the link between maltreatment in childhood and living in high‐risk neighborhoods in middle adulthood. Problem behaviors were assessed at mean age of 29 and neighborhood characteristics were assessed at mean age of 40. Child maltreatment predicted living in less desirable neighborhoods in middle adulthood. Problem behaviors in young adulthood partially mediated the relationship between childhood maltreatment and residence in less desirable neighborhoods in middle adulthood. The direct paths from child maltreatment to neighborhoods were not significant for Black children. For White children, there was a direct relationship between child maltreatment and living in an economically disadvantaged neighborhood. Problem behaviors were a stronger mediator between child maltreatment and living in more disordered and less socially cohesive neighborhoods for Black children, while the problem behaviors were a stronger mediator for living in more economically disadvantaged and less socially cohesive neighborhoods for White children. Further research is needed to understand these racial differences. Interventions should focus on preventing problem behaviors to minimize the risk of residency in high‐risk neighborhoods.
On modeling of bitumen/n‐tetradecane mixture viscosity: Application in solvent‐assisted recovery method
Authors: Rostami Alireza , Arabloo Milad , Esmaeilzadeh Shaghayegh , Mohammadi Amir H. 
Published: December 2017

AbstractExtremely high viscosity of bitumen is of great challenge in bitumen production, transportation, and processing. Therefore, different techniques such as dilution of bitumen by liquid solvents have been proposed for bitumen viscosity reduction. Accurate prediction of diluted bitumen mixture viscosity is a key parameter in solvent injection during hydrocarbon recovery. In this study, a simple correlation and a model in accordance with adaptive neuro‐fuzzy inference systems joined with particle swarm optimization (ANFIS‐PSO) algorithm have been developed for accurate estimation of bitumen/n‐tetradecane mixture viscosity in comparison to other available mixing rules at different pressures, temperatures, and n‐tetradecane mass fractions. For evaluation of the models efficiency, cumulative frequency test was employed to examine the data frequency over the whole databank. The ANFIS‐PSO model exhibits the best performance with average absolute relative deviation of 2.44% and squared correlation coefficient (R2) of 0.9985. Moreover, it is proved that the suggested correlation has the best practical performance than the Lederer and other studied correlations in this work. In other words, the proposed correlation is easy‐to‐use and also, it is a more straightforward function of pressure, temperature, and solvent mass fraction than other literature correlations. Based on the sensitivity analysis, it is demonstrated that solvent concentration is the most influencing parameter in reducing bitumen viscosity. In accordance to the results of this study, the proposed techniques can serve as robust and reliable tools for efficient estimation of bitumen/n‐tetradecane mixture viscosity.
Cellulose micro‐ and nanofibrils (CMNF) manufacturing ‐ financial and risk assessment
Authors: de Assis Camilla Abbati , Iglesias Maria Celeste , Bilodeau Michael , Johnson Donna , Phillips Richard , Peresin Maria Soledad , Bilek E.M. (Ted) , Rojas Orlando J. , Venditti Richard , Gonzalez Ronalds 
Published: December 2017

AbstractConversion economics, risk, and financial analyses for an industrial facility manufacturing cellulose micro‐ and nanofibrils (CMNF) from wood pulp is presented. Process data is based on mass and energy balances from a pilot facility in the University of Maine. Here, CMNF is produced from untreated wood pulp by using disk refining, with an assumed production capacity of 50 t (dry metric ton equivalent) per day. Stand‐alone and co‐location manufacturing facilities were simulated and assessed. Minimum product selling prices (MPSP, estimated to achieve a 16% hurdle rate) for different scenarios ranged from USD 1893/t CMNF to USD 2440/t CMNF (dry equivalent). Pulp and energy consumption were identified as major cost drivers. Consequently, it was found that the use of alternative feedstock, in addition to co‐location configuration, can reduce MPSP by 37%. Since estimated MPSP of CMNF is lower than cellulose nanocrystals (CNC) – both estimated to achieve a 16% hurdle rate, we believe market adoption of CMNF in the near term is more promising, regardless of specific applications. This study provides state of the art business intelligence information on the conversion economics, risk, and financial analyses for CMNF manufacturing. Thus, the data represents valuable information to entrepreneurs, R&D scientists, and product developers who plan to adopt CMNF in their processes and products. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd
Calpain‐2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme
Authors: Marciel Michael P. , Rose Aaron H. , Martinez Verena , Horio David T. , Hashimoto Ann S. , Hoffmann FuKun W. , Bertino Pietro , Hoffmann Peter R. 
Published: December 2017

AbstractCalpain‐2 levels are higher in colorectal tumors resistant to chemotherapy and previous work showed calpain‐2 inhibitor therapy reduced inflammation‐driven colorectal cancer, but direct effects of the inhibitor on colon cancer cells themselves were not demonstrated. In the present study, five human colon cancer cell lines were directly treated with a calpain‐2 inhibitor and results showed increased cell death in 4 of 5 cell lines and decreased anchorage‐independent growth for all cell five lines. When tested for levels of calpain‐2, three cell lines exhibited increasing levels of this enzyme: HCT15 (low), HCC2998 (medium), and HCT116 (significantly higher). This was consistent with gel shift assays showing that calpain‐2 inhibitor reduced of NF‐κB nuclear translocation most effectively in HCT116 cells. Ability of calpain‐2 inhibitor to impede tumor progression in vivo was evaluated using intrarectal transplant of luciferase‐expressing cells for these three cell lines. Results showed that calpain‐2 inhibitor therapy reduced tumor growth and increased survival only in mice injected with HCT116 cells. These data suggest calpain‐2 inhibitor treatment may be most effective on colorectal tumors expressing highest levels of calpain‐2.
Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families
Authors: Rakers Christin , Najnin Rifat Ara , Polash Ahsan Habib , Takeda Shunichi , Brown J.B. 
Published: December 2017

AbstractComputational models for predicting the activity of small molecules against targets are now routinely developed and used in academia and industry, partially due to public bioactivity databases. While models based on bigger datasets are the trend, recent studies such as chemogenomic active learning have shown that only a fraction of data is needed for effective models in many cases. In this article, the chemogenomic active learning method is discussed and used to newly analyze public databases containing nuclear hormone receptor and cytochrome P450 enzyme family bioactivity. In addition to existing results on kinases and G‐protein coupled receptors, results here demonstrate the active learning methodology's effectiveness on extracting informative ligand–target pairs in sparse data scenarios. Experiments to assess the domain of the applicability demonstrate the influence of ligand profiles of similar targets within the family.
Nurse species and indirect facilitation through grazing drive plant community functional traits in tropical alpine peatlands
Authors: Danet Alain , Kéfi Sonia , Meneses Rosa I. , Anthelme Fabien 
Published: December 2017

AbstractFacilitation among plants mediated by grazers occurs when an unpalatable plant extends its protection against grazing to another plant. This type of indirect facilitation impacts species coexistence and ecosystem functioning in a large array of ecosystems worldwide. It has nonetheless generally been understudied so far in comparison with the role played by direct facilitation among plants. We aimed at providing original data on indirect facilitation at the community scale to determine the extent to which indirect facilitation mediated by grazers can shape plant communities. Such experimental data are expected to contribute to refining the conceptual framework on plant–plant–herbivore interactions in stressful environments. We set up a 2‐year grazing exclusion experiment in tropical alpine peatlands in Bolivia. Those ecosystems depend entirely on a few, structuring cushion‐forming plants (hereafter referred to as “nurse” species), in which associated plant communities develop. Fences have been set over two nurse species with different strategies to cope with grazing (direct vs. indirect defenses), which are expected to lead to different intensities of indirect facilitation for the associated communities. We collected functional traits which are known to vary according to grazing pressure (LDMC, leaf thickness, and maximum height), on both the nurse and their associated plant communities in grazed (and therefore indirect facilitation as well) and ungrazed conditions. We found that the effect of indirectly facilitated on the associated plant communities depended on the functional trait considered. Indirect facilitation decreased the effects of grazing on species relative abundance, mean LDMC, and the convergence of the maximum height distribution of the associated communities, but did not affect mean height or cover. The identity of the nurse species and grazing jointly affected the structure of the associated plant community through indirect facilitation. Our results together with the existing literature suggest that the “grazer–nurse–beneficiary” interaction module can be more complex than expected when evaluated in the field.
The Groot Effect: Plant facilitation and desert shrub regrowth following extensive damage
Authors: Lortie Christopher J. , Gruber Eva , Filazzola Alex , Noble Taylor , Westphal Michael 
Published: December 2017

AbstractDeserts are increasing in extent globally, but existing deserts are decreasing in health. The basic biology and ecology of foundation plant species in deserts are limited. This is a direct study that provides an estimate of the capacity for a locally dominant foundation shrub species in California to recover from damage. Desert shrubs are cleared and damaged by humans for many purposes including agriculture, oil and gas production, and sustainable energy developments; we need to know whether foundation species consistently facilitate the abundance and diversity of other plants in high‐stress ecosystems and whether they can recover. A total of 20 Ephedra californica shrubs were clipped to the ground at a single site and systematically resampled for regrowth 2 years later. These shrubs were damaged once and regrew rapidly, and relatively, larger shrubs were not more resilient. This study provides evidence for what we termed the “Groot Effect” because smaller individuals of this shrub species can recover from significant aboveground damage and continue to have positive effects on other plant species (similar to the popular culture reference to a benefactor tree species). The density of other plant species was consistently facilitated while effects on diversity varied with season. These findings confirm that E. californica is a foundation species that can be an important restoration tool within the deserts of California in spite of extreme cycles of drought and physical damage to its canopy.