bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice
Authors: Masi Laureane Nunes , Martins Amanda Roque , Crisma Amanda Rabello , do Amaral Cátia Lira , Davanso Mariana Rodrigues , Serdan Tamires Duarte Afonso , da Cunha de Sá Roberta Dourado Cavalcante , Cruz Maysa Mariana , Alonso-Vale Maria Isabel Cardoso , Torres Rosângela Pavan , Mancini-Filho Jorge , Pereira Joice Naiara Bertaglia , da Silva Righetti Marta Maria , Liberti Edson Aparecido , Hirabara Sandro Massao , Curi Rui 
Published: June 2017

AbstractObesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-α by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1β, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state.
Strain-balanced type-II superlattices for efficient multi-junction solar cells
Authors: Gonzalo A. , Utrilla A. D. , Reyes D. F. , Braza V. , Llorens J. M. , Fuertes Marrón D. , Alén B. , Ben T. , González D. , Guzman A. , Hierro A. , Ulloa J. M. 
Published: June 2017

AbstractMulti-junction solar cells made by assembling semiconductor materials with different bandgap energies have hold the record conversion efficiencies for many years and are currently approaching 50%. Theoretical efficiency limits make use of optimum designs with the right lattice constant-bandgap energy combination, which requires a 1.0–1.15 eV material lattice-matched to GaAs/Ge. Nevertheless, the lack of suitable semiconductor materials is hindering the achievement of the predicted efficiencies, since the only candidates were up to now complex quaternary and quinary alloys with inherent epitaxial growth problems that degrade carrier dynamics. Here we show how the use of strain-balanced GaAsSb/GaAsN superlattices might solve this problem. We demonstrate that the spatial separation of Sb and N atoms avoids the ubiquitous growth problems and improves crystal quality. Moreover, these new structures allow for additional control of the effective bandgap through the period thickness and provide a type-II band alignment with long carrier lifetimes. All this leads to a strong enhancement of the external quantum efficiency under photovoltaic conditions with respect to bulk layers of equivalent thickness. Our results show that GaAsSb/GaAsN superlattices with short periods are the ideal (pseudo)material to be integrated in new GaAs/Ge-based multi-junction solar cells that could approach the theoretical efficiency limit.
Transcriptome changes between compatible and incompatible graft combination of Litchi chinensis by digital gene expression profile
Authors: Chen Zhe , Zhao Jietang , Hu Fuchu , Qin Yonghua , Wang Xianghe , Hu Guibing 
Published: June 2017

AbstractPlant grafting has been practiced widely in horticulture and proved as a useful tool in science. However, the mechanisms of graft healing or graft incompatibility remain poorly understood. In this study, Litchi chinensis cv. ‘Jingganghongnuo’ homograft (‘J/J’) and ‘Jingganghongnuo’/‘zhuangyuanhong’ heterograft (‘J/Z’) as compatible and incompatible combination, respectively, was used to study transcriptional changes between incompatible and compatible graft during graft union formation. Anatomical observation indicated that three stages (2 h, 14 d and 21 d after grafting) were critical for graft union formation and selected for high-throughput sequencing. Results indicated 6060 DEGs were differentially expressed in the compatible combination and 5267 DEGs exhibiting in the incompatible one. KEGG pathway enrichment analysis revealed that DEGs were involved in metabolism, wound response, phenylpropanoid biosynthesis and plant hormone signal transduction. The expression of 9 DEGs annotated in auxin pathway was up-regulated in compatible combination than that in incompatible combination. The IAA concentration confirmed that the IAA might promote the graft compatibility. In addition, 13 DEGs related to lignin biosynthesis were differentially expressed during graft healing process. Overall, our results provide abundant sequence resources for studying mechanisms underlying graft compatibility and establish a platform for further studies of litchi and other evergreen fruit trees.
On the interaction of toxic Heavy Metals (Cd, Hg, Pb) with graphene quantum dots and infinite graphene
Authors: Shtepliuk Ivan , Caffrey Nuala M. , Iakimov Tihomir , Khranovskyy Volodymyr , Abrikosov Igor A. , Yakimova Rositsa 
Published: June 2017

AbstractThe promise of graphene and its derivatives as next generation sensors for real-time detection of toxic heavy metals (HM) requires a clear understanding of behavior of these metals on the graphene surface and response of the graphene to adsorption events. Our calculations herein were focused on the investigation of the interaction between three HMs, namely Cd, Hg and Pb, with graphene quantum dots (GQDs). We determine binding energies and heights of both neutral and charged HM ions on these GQDs. The results show that the adsorption energy of donor-like physisorbed neutral Pb atoms is larger than that of either Cd or Hg. In contrast to the donor-like behavior of elemental HMs, the chemisorbed charged HM species act as typical acceptors. The energy barriers to migration of the neutral adatoms on GQDs are also estimated. In addition, we show how the substitution of a carbon atom by a HM adatom changes the geometric structure of GQDs and hence their electronic and vibrational properties. UV-visible absorption spectra of HM-adsorbed GQDs vary with the size and shape of the GQD. Based on our results, we suggest a route towards the development of a graphene-based sensing platform for the optical detection of toxic HMs.
Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR
Authors: Igata Natsuki , Kakeda Shingo , Watanabe Keita , Ide Satoru , Kishi Taro , Abe Osamu , Igata Ryouhei , Katsuki Asuka , Iwata Nakao , Yoshimura Reiji , Korogi Yukunori 
Published: June 2017

AbstractIndividuals with s/s genotype of serotonin transporter gene-linked promotor region (5-HTTLPR), which appear with a high frequency in Japanese, exhibit more diagnosable depression in relation to stressful life events than those with the s/l or l/l genotype. We prospectively investigated the brain volume changes in first-episode and medication naïve major depression disorder patients (MDD) with the s/s genotype in Japanese. We assessed the differences between 27 MDD with the s/s genotype and 44 healthy subjects (HS) with the same genotype using a whole-brain voxel-by-voxel statistical analysis of MRI. Gray matter volume in a brain region with significant clusters obtained via voxel-based morphometry analysis were measured and, as an exploratory analysis, evaluated for relationships to the subcategory scores (core, sleep, activity, psychic, somatic anxiety, delusion) of the Hamilton Depression Rating Scale (HAM-D) and the Social Readjustment Rating Scale (SRRS). The brain volume in the left insula lobe was significantly smaller in the MDD than in the HS. The left insula lobe volume correlated negatively with the “psychic” score of HAM-D and the SRRS. In a Japanese population with the s/s genotype, we found an atrophy of the insula in the MDD, which might be associated with “psychic” symptom and stress events.
Treatment of Chronic Allergic Rhinitis and Sinusitis with Homeopathy
Authors: Wandile Pranali 
Published: June 2017

AbstractAllergic rhinitis and sinusitis are one of the most common chronic upper respiratory tract medical conditions. As they occur simultaneously or coexist together, the correct term for these conditions will be allergic rhinosinusitis. The challenging question arises in mind whether all allergic patients are immune deficient in some way. Therefore, samples from well-diagnosed allergic patients need to be evaluated genetically using a candidate gene and a whole-genome scan approach. A better understanding of the pathogenesis and the causative factors responsible for increased mucosal inflammation is important for the development of new diagnostic and therapeutic tools. Previous research showed the association between sensitisation tendency and the genetic factors associated with allergic upper respiratory tract conditions. More research needs to be conducted on genetic factors component for allergic chronic rhinosinusitis. Homeopathy offers lot of potential in treating various genetic disorders and it has contributed in treating patients with allergic, autoimmune and hereditary disorders worldwide. In homeopathy science, more research needs to be published which includes patient cases—who has been treated successfully with homeopathy medicines for allergic chronic rhinosinusitis.
Proximal Left Main Bronchus Resection–Reconstruction through Left Thoracotomy with Tracheal Traction
Authors: Imanishi Naoko , Takenaka Masaru , Hirai Ayako , Tanaka Fumihiro 
Published: June 2017

AbstractSurgical approach for resection–reconstruction of the proximal left main bronchus has been a matter of discussion. Through standard left thoracotomy, the proximal main bronchus close to the carina is not easily exposed. Accordingly, median sternotomy or right thoracotomy may be commonly employed, but the exposure and management of the distal left main bronchus may be difficult through the approach. Here, we present a left thoracotomy approach with traction of the trachea, which may easily allow excellent exposure of the proximal end of the left main bronchus and the carina.
Clinical Neurophysiology in Neuromuscular Disorders: Old Fashioned or Still Relevant?
Authors: Vill Katharina , Müller-Felber Wolfgang 
Published: June 2017

AbstractClinical neurophysiology still has a role in the diagnostic process of pediatric neuromuscular disorders. It should be integrated into a stepwise diagnostic process which includes a first step clinical examination to build a clinical hypothesis, followed by muscle ultrasound, and finally clinical neurophysiology where it is necessary. There is still a need for further research if new techniques such as impedance myography, motor unit counting, and others give additional information and if they can be used to evaluate the efficacy of new drugs.
Rescue Decompressive Craniectomy in Children with Severe Traumatic Brain Injury
Authors: Poulos Panagiotis , Kazantzi Maria , Kalampalikis Panagiotis , Rallis Dimitrios 
Published: June 2017

AbstractDecompressive craniectomy (DC) is considered a rescue therapy in patients with traumatic brain injury (TBI) with increased intracranial pressure (ICP). In this retrospective study, we examined the impact of craniectomy on ICP in children with severe TBI and their neurological outcome. A total of 14 patients were enrolled. Peak ICP was significantly lower (31 ± 2.9 to 19 ± 4.6, p < 0.001) and minimum cerebral perfusion pressure (CPP) higher (41 ± 10.5 to 58 ± 11.4, p < 0.001) postcraniectomy. The survival rate was 71%. However, 57% of our cohort had a poor neurological outcome at 6 months postinjury. In conclusion, although rescue DC was effective in controlling ICP and CPP, the long-term neurological outcome remained poor.
Iconicity is in the eye of the beholder
Authors: Occhino Corrine , Anible Benjamin , Wilkinson Erin , Morford Jill P. 
Published: June 2017

Abstract
A renewed interest in understanding the role of iconicity in the structure and processing of signed languages is hampered by the conflation of iconicity and transparency in the definition and operationalization of iconicity as a variable. We hypothesize that iconicity is fundamentally different than transparency since it arises from individuals’ experience with the world and their language, and is subjectively mediated by the signers’ construal of form and meaning. We test this hypothesis by asking American Sign Language (ASL) signers and German Sign Language (DGS) signers to rate iconicity of ASL and DGS signs. Native signers consistently rate signs in their own language as more iconic than foreign language signs. The results demonstrate that the perception of iconicity is intimately related to language-specific experience. Discovering the full ramifications of iconicity for the structure and processing of signed languages requires operationalizing this construct in a manner that is sensitive to language experience.
On the observational characteristics of lithium-enhanced giant stars in comparison with normal red giants
Authors: Takeda Yoichi , Tajitsu Akito 
Published: June 2017

Abstract
While lithium is generally deficient in the atmosphere of evolved giant stars because of the efficient mixing-induced dilution, a small fraction of red giants show unusually strong Li lines indicative of conspicuous abundance excess. With the aim of shedding light on the origin of these peculiar stars, we carried out a spectroscopic study on the observational characteristics of 20 selected bright giants already known to be Li-rich from past studies, in comparison with the reference sample of a large number of normal late G–early K giants. Special attention was paid to clarifying any difference between the two samples from a comprehensive point of view (i.e., with respect to stellar parameters, rotation, activity, kinematic properties, 6Li/7Li ratio, and the abundances of Li, Be, C, O, Na, S, and Zn). Our sample stars are roughly divided into a “bump/clump group” and a “luminous group” according to their positions on the HR diagram. Regarding the former group [1.5 ≲ log (L/L⊙) ≲ 2 and M ∼ 1.5–3 M⊙], Li-enriched giants and normal giants appear practically similar in almost all respects except for Li, suggesting that surface Li enhancement in this group may be a transient episode which normal giants undergo at certain evolutionary stages in their lifetime. Meanwhile, those Li-rich giants belonging to the latter group [log (L/L⊙) ∼ 3 and M ∼ 3–5 M⊙] appear more anomalous in the sense that they tend to show higher rotation as well as higher activity, and that their elemental abundances (especially those derived from high-excitation lines) are apt to show apparent overabundances, though this might be due to a spurious effect reflecting the difficulty of abundance derivation in stars of higher rotation and activity. Our analysis confirmed considerable Be deficiency as well as absence of 6Li as the general characteristics of Li-rich giants under study, which implies that engulfment of planets is rather unlikely for the origin of Li-enrichment.
Demographic Characteristics and Prescribing Patterns of Scleral Lens Fitters: The SCOPE Study
Authors: Nau Cherie B. , Harthan Jennifer , Shorter Ellen , Barr Joseph , Nau Amy , Chimato Nicolette T. , Hodge David O. , Schornack Muriel M. 
Published: June 2017

Objectives:
This study reports demographic characteristics of scleral lens providers and indications for scleral lens prescription as assessed by a worldwide online survey.

Methods:
The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group designed the online survey regarding current scleral lens prescription and management practices. The Mayo Clinic Survey Research Center administered the survey, which was open from January 15 to March 31, 2015. Data from 989 responses were collated by the Survey Research Center and deidentified before analysis. Responses of individuals who had fit at least five patients with scleral lenses were analyzed in detail.

Results:
Most lens fitters were men (61%, n=800). Of survey respondents, 29% were 25 to 34 years; 22%, 35 to 44 years; 22%, 45 to 54 years; and 26%, more than 55 years (n=806). For 29% of all respondents, professional training was completed between 2009 and 2014 (n=804). Most (54%) fit their first patient between 2010 and 2015, with the earliest lens fit reported in 1956 (n=634). Most respondents (63%) worked primarily in private, group, or retail practice (n=811). Scleral lenses were most often prescribed for corneal irregularity (74%), followed by ocular surface disease (16%) and uncomplicated refractive error (10%) (n=673).

Conclusions:
Eye care providers of all ages are fitting scleral lenses. The number of individuals who fit this lens modality has increased during the past decade. Scleral lenses are being fit by providers in a wide range of practice settings. Most scleral lenses are prescribed for corneal irregularity.
The Effects of Latanoprost With Benzalkonium Chloride Versus Travoprost With SofZia on the Ocular Surface
Authors: Rahmatnejad Kamran , Rapuano Christopher J. , Ichhpujani Parul , Wizov Sheryl S. , Moster Marlene R. , Hark Lisa A. , Katz L. Jay 
Published: June 2017

Purpose:
To assess ocular surface changes in participants using latanoprost with benzalkonium chloride (Xalatan) and travoprost with SofZia (Travatan Z).

Methods:
In this prospective, open-label, nonrandomized cohort study, participants were classified into two groups: group 1 (n=28) naive to glaucoma therapy, group 2 (n=27) on previous Xalatan monotherapy in both eyes. Both groups started (or continued) Xalatan in the right eye and Travatan Z in the left eye. Baseline, 1-, and 2-month measurements of tear breakup time (TBUT), corneal staining score, conjunctival staining score, conjunctival hyperemia score, tear production, and intraocular pressure were obtained. The Ocular Surface Disease Index questionnaire measured participants' comfort and dryness symptoms. Medication preference was recorded.

Results:
Data were collected from 55 participants. Tear breakup time at baseline and 1-month follow-up in group 1 was significantly longer than that of group 2 (P=0.005). At 2 months, there was no significant difference in TBUT between the two groups (P=0.779). Tear production in group 1 at all three time points was significantly higher than group 2 (P<0.05). Conjunctival staining score at 2 months in group 1 was significantly higher than group 2 (P=0.031). There was no significant difference in other parameters between the groups at any other time point. No significant difference in any parameter was found between Xalatan and Travatan Z (intragroup comparison).

Conclusions:
Significant differences in ocular surface characteristics were detected between groups, but no significant difference was detected between participants treated with Xalatan and Travatan Z.
Treatment of Klebsiella pneumoniae Carbapenemase–Producing Klebsiella pneumoniae Bacteremia With Meropenem, Colistin, and Ceftazidime-Avibactam
Authors: Harrison Kiya , Smith Winter , Kupiec Katherine , Salinas Linda , McCloskey Cindy , Robison Denise , Salvaggio Michelle 
Published: June 2017

Abstract
Ceftazidime-avibactam is a novel combination antimicrobial agent consisting of a broad-spectrum cephalosporin, ceftazidime, and a non–β-lactam β-lactamase inhibitor, avibactam. This agent has demonstrated activity against resistant gram-negative bacteria, including Klebsiella pneumoniae carbapenemase–producing organisms; however, it is US Food and Drug Administration approved for use in urinary tract and intra-abdominal infections only. We present a case of successful treatment of K. pneumoniae carbapenemase–producing K. pneumoniae bacteremia with a combination of meropenem and colistin followed by ceftazidime-avibactam and colistin.
An Illustration of Errors in Using the P Value to Indicate Clinical Significance or Epidemiological Importance of a Study Finding
Authors: Kang Joseph , Hong Jaeyoung , Esie Precious , Bernstein Kyle T. , Aral Sevgi 
Published: June 2017

Abstract
We conducted a simulation study to illustrate that P values can suggest but not confirm statistical significance; and they may not indicate epidemiological significance (importance). We recommend that researchers consider reporting effect sizes as P values in conjunction with confidence intervals or point estimates with standard errors to indicate precision (uncertainty).
Oropharyngeal Colostrum Administration in Very Low Birth Weight Infants: A Randomized Controlled Trial*
Authors: Zhang Yuxia , Ji Futing , Hu Xiaojing , Cao Yun , Latour Jos M. 
Published: June 2017

Objectives:
Studies have confirmed the safety of oropharyngeal administration of colostrum in very low birth weight infants. However, the effect of oropharyngeal administration of colostrum on immune system is inconclusive. This study aims to evaluate the effect of oropharyngeal administration of colostrum on secretory immunoglobulin A and lactoferrin in very low birth weight infants.

Design:
Randomized controlled trial.

Setting:
Forty-bedded neonatal ICU in a university children’s hospital in the People’s Republic of China.

Patients:
Very low birth weight infants were allocated to the study group (n = 32) and control group (n = 32).

Intervention:
The intervention was oropharyngeal administration of 0.2 mL of their mother’s colostrum every 4 hours for 7 days. The control group received saline solution.

Measurements and Main Results:
Secretory immunoglobulin A and lactoferrin in urine and saliva were measured within 24 hours of life (baseline) and at 7 and 21 days. Primary outcomes were changes of secretory immunoglobulin A and lactoferrin in urine and saliva between baseline and at 7 and 21 days. Infant’s clinical data were also collected during hospitalization. Change from baseline in lactoferrin in saliva at 7 days (5.18 ± 7.07 vs –1.74 ± 4.67 µg/mL; p < 0.001) and 21 days (5.31 ± 9.74 vs –1.17 ± 10.38 µg/mL; p = 0.02) shows statistic difference. No differences were found of lactoferrin in urine and also no differences of secretory immunoglobulin A in urine and saliva. There were also no differences between days to full enteral feeding, occurrence rate of clinical sepsis, proven sepsis, and necrotizing enterocolitis.

Conclusions:
Oropharyngeal administration of colostrum can increases the level of lactoferrin in saliva in very low birth weight infants. No effect could be documented of secretory immunoglobulin A and lactoferrin in urine. Larger trials are needed to better describe the benefit of oropharyngeal administration of colostrum, if any, in very low birth weight infants.