bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia
Authors: Gaksch Lukas , Kashofer Karl , Heitzer Ellen , Quehenberger Franz , Daga Shruti , Hofer Sybille , Halbwedl Iris , Graf Ricarda , Krisper Nina , Hoefler Gerald , Zebisch Armin , Sill Heinz , Wölfler Albert 
Published: September 2017

AbstractDespite achieving complete remission after intensive therapy, most patients with cytogenetically normal (CN) AML relapse due to the persistence of submicroscopic residual disease. In this pilot study, we hypothesized that detection of leukemia‐specific mutations following consolidation treatment using a targeted parallel sequencing approach predicts relapse. We included 34 AML patients of whom diagnostic material and remission bone marrow slides after at least one cycle of consolidation were available. Isolated DNA was screened for mutations in 19 genes using an Ion Torrent sequencing platform. Furthermore, the variant allelic frequency of distinct mutations was validated by digital PCR and sequencing using a barcoding approach. Twenty‐seven out of 34 patients could be analyzed for mutation clearance. We identified 68 somatic mutations at diagnosis (median, 3 mutations per patient; range 1‐5) and 22 of these were still detected in 16 patients after consolidation therapy with a reliable sensitivity of 0.5% (median, 1 mutation; range 0‐3). The most frequent noncleared mutations were found in DNMT3A. However, as persistence of these mutations has recently been shown to be without any impact on relapse risk, we performed survival and relapse risk analysis excluding DNMT3A mutations. Importantly, persistence of non‐DNMT3A mutations was associated with a higher risk of AML relapse (7/8 pts versus 6/19 pts; P = .013) and with a shorter relapse‐free survival (333 days vs. not reached; log‐rank P = .0219). Detection of residual disease by routine targeted parallel sequencing proved feasible and effective as persistence of somatic mutations other than DNMT3A were prognostic for relapse in CN AML.
Changing the Mechanism for CO2 Hydrogenation Using Solvent‐Dependent Thermodynamics
Authors: Burgess Samantha A. , Appel Aaron M. , Linehan John C. , Wiedner Eric S. 
Published: September 2017

AbstractA critical scientific challenge for utilization of CO2 is the development of catalyst systems that function in water and use inexpensive and environmentally friendly reagents. We have used thermodynamic insights to predict and demonstrate that the HCoI(dmpe)2 catalyst system, previously described for use in organic solvents, can hydrogenate CO2 to formate in water with bicarbonate as the only added reagent. Replacing tetrahydrofuran as the solvent with water changes the mechanism for catalysis by altering the thermodynamics for hydride transfer to CO2 from a key dihydride intermediate. The need for a strong organic base was eliminated by performing catalysis in water owing to the change in mechanism. These studies demonstrate that the solvent plays a pivotal role in determining the reaction thermodynamics and thereby catalytic mechanism and activity.
Salt‐leaching technique for the synthesis of porous poly(2,5‐benzimidazole) (ABPBI) membranes for fuel cell application
Authors: Das Annesha , Ghosh Priyanka , Ganguly Saibal , Banerjee Dipali , Kargupta Kajari 
Published: September 2017

ABSTRACTThe first instance of synthesizing porous poly(2,5‐benzimidazole) (ABPBI) membranes for high‐temperature polymer electrolyte membrane fuel cells (HT‐PEMFCs), using solvent evaporation/salt‐leaching technique, is reported herein. Various ratios of sodium chloride/ABPBI were dissolved in methanesulfonic acid and cast into membranes by solvent evaporation, followed by porogen (salt) leaching by water washing. The membranes were characterized using SEM, FTIR, TGA, and DSC. The proton conductivity, water and acid uptake of the membranes were measured and the chemical stability was determined by Fenton's test. SEM images revealed strong dependence of sizes and shapes of pores on the salt/polymer ratios. Surface porosities of membranes were estimated with Nis Elements‐D software; bulk porosities were measured by the fluid resaturation method. Thermogravimetric analysis showed enhanced dopant uptake with introduction of porosity, without the thermal stability of the membrane compromised. Incorporating pores enhanced solvent uptake and retention because of capillarity effects, enhancing proton conductivities of PEMs. Upon acid doping, a maximum conductivity of 0.0181 S/cm was achieved at 130 °C for a porous membrane compared with 0.0022 S/cm for the dense ABPBI membrane at the same temperature. Results indicated that with judicious optimization of porogen/polymer ratios, porous ABPBI membranes formed by salt‐leaching could be suitably used in HT‐PEMFCs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45773.
Hybrid composites based on technical cellulose from rice husk
Authors: Shapovalova Irina , Vurasko Alesya , Petrov Lev , Kraus Eduard , Leicht Heinrich , Heilig Michael , Stoyanov Oleg 
Published: September 2017

ABSTRACTWe introduced the preparation of hybrid composites using technical cellulose as a matrix material from rice husks with a natural SiO2 content from 0% to 19.4%. In this work, the physicochemical characteristics of the resulting hybrid composites have been investigated. The presence of SiOC chemical bonds in the resulting hybrid composites was determined by infrared spectroscopy. Microscopic analysis showed the complete removal of the mineral component and lignin from the cell wall of the rice husk fibers. This allows obtaining of an expanded surface of the fibers (101.7 m2/g) with uniform distribution of the TiO2 aggregates. It could be shown that with content increasing of natural silicon dioxide in the hybrid composite the decomposition rate of H2O2 also increases. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45796.
The application of crowdsourcing approaches to cancer research: a systematic review
Authors: Lee Young Ji , Arida Janet A. , Donovan Heidi S. 
Published: September 2017

AbstractCrowdsourcing is “the practice of obtaining participants, services, ideas, or content by soliciting contributions from a large group of people, especially via the Internet.” (Ranard et al. J. Gen. Intern. Med. 29:187, 2014) Although crowdsourcing has been adopted in healthcare research and its potential for analyzing large datasets and obtaining rapid feedback has recently been recognized, no systematic reviews of crowdsourcing in cancer research have been conducted. Therefore, we sought to identify applications of and explore potential uses for crowdsourcing in cancer research. We conducted a systematic review of articles published between January 2005 and June 2016 on crowdsourcing in cancer research, using PubMed, CINAHL, Scopus, PsychINFO, and Embase. Data from the 12 identified articles were summarized but not combined statistically. The studies addressed a range of cancers (e.g., breast, skin, gynecologic, colorectal, prostate). Eleven studies collected data on the Internet using web‐based platforms; one recruited participants in a shopping mall using paper‐and‐pen data collection. Four studies used Amazon Mechanical Turk for recruiting and/or data collection. Study objectives comprised categorizing biopsy images (n = 6), assessing cancer knowledge (n = 3), refining a decision support system (n = 1), standardizing survivorship care‐planning (n = 1), and designing a clinical trial (n = 1). Although one study demonstrated that “the wisdom of the crowd” (NCI Budget Fact Book, 2017) could not replace trained experts, five studies suggest that distributed human intelligence could approximate or support the work of trained experts. Despite limitations, crowdsourcing has the potential to improve the quality and speed of research while reducing costs. Longitudinal studies should confirm and refine these findings.
Small bowel stenosis following blunt abdominal trauma: a case report
Authors: Prince Sheela , Busharar Hajer Abdullah Saleh , AlZoabi Osama Mohemmed 
Published: September 2017

Key Clinical MessageBlunt abdominal trauma is a rare case of intestinal obstruction, and only few cases have been reported in the world literature. Stenotic intestinal obstruction following blunt abdominal trauma is a very rare complication. This case highlights the need for clinical suspicion serial clinical assessment and radiological evaluation and the need for early surgery in patients presenting with abdominal symptoms following blunt abdominal trauma.
Gastric trichobezoar
Authors: Szor Daniel José , Dias André Roncon 
Published: September 2017

Key Clinical MessageTrichobezoar is a rare gastrointestinal pathology, but should be considered in patients with abdominal mass and previous history of trichophagia. In physical examination, it is important to verify signs of alopecia. Minimally invasive surgery is a secure method to remove the specimen from the stomach.
Self‐Assembly of Novel Thiophene‐Based BODIPY RuII Rectangles: Potential Antiproliferative Agents Selective Against Cancer Cells
Authors: Gupta Gajendra , Das Abhishek , Panja Sourav , Ryu Ji Yeon , Lee Junseong , Mandal Nripendranath , Lee Chang Yeon 
Published: September 2017

AbstractNovel Ru (2+2) rectangles were designed and synthesized by self‐assembly of a new thiophene‐functionalized dipyridyl BODIPY ligand, BDPS, and ruthenium(II) precursors. The complexes exhibited dose‐dependent antiproliferative activities against cancer cells, in which some compounds selectively kill cancer cells. The net fluorescence due to BODIPY allowed us to visualize their location inside cancer cells. Moreover, the metalla‐rectangles displayed substantial propensity to bind with biomolecules.
Inside Cover: General Reductive Amination of Aldehydes and Ketones with Amines and Nitroaromatics under H2 by Recyclable Iridium Catalysts (Chin. J. Chem. 9/2017)
Authors: Sui Dejun , Mao Fei , Fan Haipeng , Qi Zhengliang , Huang Jun 
Published: September 2017

The inside cover picture shows secondary and tertiary amines, which are important intermediates in organic synthesis for the preparation of natural products, pharmaceutical and agronomical compounds. The direct reductive amination of aldehydes and ketones represents a powerful tool for the preparation of secondary and tertiary amines. Here, direct and general reductive amination of aldehydes and ketones with amines and nitroaromatics was presented under H2 using recyclable iridium catalysts, and lots of secondary and tertiary amines were produced in high yields. Moreover, the heterogeneous iridium catalysts Ir@NC(600‐2h) can be reused several times without evident deactivation. More details are discussed in the article by Huang et al. on page 1371–1377.
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Improved outsourced private set intersection protocol based on polynomial interpolation
Authors: Yang Xiaoyuan , Luo Xiaoshuang , Wang Xu An , Zhang Shuaiwei 
Published: September 2017

SummaryPrivate set intersection (PSI) protocols enable 2 parties to compute the intersection of their inputs without compromising anything about the datasets beyond the intersection. With the advent of cloud computing, outsourcing computation has been attracted wide range of attention from research community and applied widely in the industry. The cloud computing allows resources restrained devices to outsource their expensive computation to the cloud. Based on Abadi's O‐PSI, we present a variant of delegated private set intersection protocol secure in the semi‐honest model under RSA assumption, and we also give an efficient and secure outsourcing computation algorithm for RSA cryptosystem. Depending on this algorithm, we transform a variant of delegated private set intersection protocol into an improved outsourced one. It enables the clients only to perform simple modular multiplication for computing what they want during the execution of protocol. Besides, the variant of delegated protocol can be easily extended to multiple clients. Compared with the state of the art, our proposed protocol has great advantage in efficiency. We finally evaluate these protocols and prove their security in the semi‐honest model.
“Atypical” salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability
Authors: Wang He , Malik Aatika , Maleki Zahra , Rossi Esther Diana , Ping Bo , Chandra Ashish , Ali Syed Z. , Fadda Guido , Wang Jindong , Arab Seyedeh Elham , Zhao Huaqing , Jhala Nirag 
Published: September 2017

BackgroundFine needle aspiration (FNA) is widely used in the diagnosis of salivary gland lesions. Salivary gland FNAs are often difficult to diagnose because of morphologic heterogeneity, a small but significant number of the FNAs yield “atypical” diagnosis. However, systematic evaluation of the risk of malignancy (ROM) of the atypical diagnoses across institutions and the variability of ROM among institutions are still lacking.MethodsSalivary gland FNAs from five tertiary medical centers of United States, Europe and China were reviewed. Cases with “atypical” diagnosis and histological follow‐up were included in this study. The diagnostic category of “atypical” was adopted from Milan System for Reporting Salivary Gland Cytopathology (MSRSGC, personal communication).ResultsAmong the 12,606 salivary gland FNAs, 504 (4.0%) cases were reported as “atypical”, with 154 cases (30.6%) having histological follow‐ups. Histological follow‐ups revealed 94 malignant tumors (61.0%, 57 lymphomas, 33 carcinomas, 2 sarcomas, 1 metastatic melanoma, 1 metastatic neuroblastoma), 33 benign tumors (21.4%), and 25 benign lesions (16.2%). ROM in the subset of “atypical” cases with histological follow‐up from different institutions vary from 73.08% to 0.00%, the Pearson chi2 = 24.38 and P < .001.ConclusionsMore than half of the subset of “atypical” salivary gland FNAs with histological resection turned out to be malignant tumors; another one‐fourth were benign neoplasms. Further, the highly variable ROMs of the “atypical” category amongst different institutions likely reflect the variable practices at each individual institution.
Cohesize zone‐based modeling of nano‐coating layers for the purpose of establishing process signatures
Authors: Rezaei S. , Kochmann J. , Wulfinghoff S. , Reese S. 
Published: September 2017

AbstractThe purpose of this work is to establish the notion of process signatures in the context of manufacture processing. In this context we provide an overview of selected computational approaches which are capable of resolving the basic features of non‐linear heterogeneous microstructures and process related boundary and loading conditions. As an example, the cohesize zone element method is employed to predict the state of damage and fracture in coated systems. The latter are composed of CrN‐ or AlN‐based protective coating layers and steel‐based substrates. The state of damage and fracture is simulated for nano‐indentation tests and discussed at different deformation stages. Furthermore, the influence of residual stresses within the polygrain microstructure on the evolution of damage and fracture is analyzed. Lastly, future developments and computational challenges are discussed.
LncRNA SOX2‐OT is a novel prognostic biomarker for osteosarcoma patients and regulates osteosarcoma cells proliferation and motility through modulating SOX2
Authors: Wang Zhi , Tan Meiyun , Chen Ge , Li Zhong , Lu Xiaobo 
Published: September 2017

AbstractLong noncoding RNA (LncRNA) SOX2 overlapping transcript (SOX2‐OT) has been shown to serve an oncogenic role in human lung cancer, hepatocellular carcinoma, and gastric cancer. However, the clinical significance and biological function of lncRNA SOX2‐OT in osteosarcoma are still unclear. LncRNA SOX2‐OT expression was measured in osteosarcoma tissues and cell lines. Loss‐of‐function and gain‐of‐function studies were performed to observe the effects of lncRNA SOX2‐OT on osteosarcoma cells proliferation, migration, invasion, and expressions of cancer stem cell biomarker. The relationship between lncRNA SOX2‐OT and SOX2 was analyzed in osteosarcoma tissues and cells. Rescued‐function studies were conducted to confirm the role of SOX2 in the regulation of lncRNA SOX2‐OT in osteosarcoma cells migration, invasion, and expression of cancer stem cell biomarkers. In our results, lncRNA SOX2‐OT expression was increased in osteosarcoma tissues and cell lines, and associated with malignant status and overall survival in osteosarcoma patients. LncRNA SOX2‐OT regulated osteosarcoma cells proliferation, migration, invasion, and expression of cancer stem cell biomarkers. LncRNA SOX2‐OT positively regulated SOX2 expression in osteosarcoma cells and positively associated with SOX2 expression in osteosarcoma tissues. The rescued‐function studies suggested that SOX2 is necessary for lncRNA SOX2‐OT induced osteosarcoma cells migration, invasion, and expression of cancer stem cell biomarkers. In conclusion, lncRNA SOX2‐OT is a prognostic biomarker for osteosarcoma patients and serves an oncogenic role to regulate osteosarcoma cells migration, invasion, and expression of cancer stem cell biomarkers. © 2017 IUBMB Life, 69(11):867–876, 2017
Rheological properties of synthetic mucus for airway clearance
Authors: Lafforgue Olivier , Seyssiecq Isabelle , Poncet Sébastien , Favier Julien 
Published: September 2017

AbstractIn this work, a complete rheological characterization of bronchial mucus simulants based on the composition proposed by Zahm et al. (Eur Respir J 1991; 4:311–315) is presented. Dynamic small amplitude oscillatory shear (SAOS) experiments, steady state (SS) flow measurements and three intervals thixotropy tests (3ITT), are carried out to investigate the global rheological complexities of simulants (viscoelasticity, viscoplasticity, shear‐thinning, and thixotropy) as a function of scleroglucan concentrations (0.5–2 wt %) and under temperatures of 20 and 37°C. SAOS measurements show that the limit of the linear viscoelastic range as well as the elasticity both increase with increasing sclerogucan concentrations. Depending on the sollicitation frequency, the 0.5 wt % gel response is either liquid‐like or solid‐like, whereas more concentrated gels show a solid‐like response over the whole frequency range. The temperature dependence of gels response is negligible in the 20–37°C range. The Herschel–Bulkley (HB) model is chosen to fit the SS flow curve of simulants. The evolution of HB parameters versus polymer concentration show that both shear‐thinning and viscoplasticity increase with increasing concentrations. 3ITTs allow calculation of recovery thixotropic times after shearings at 100 or 1.6 s−1. Empiric correlations are proposed to quantify the effect of polymer concentration on rheological parameters of mucus simulants. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 386–396, 2018.
HPLC‐MS/MS: A potential method to track the in vivo degradation of zein‐based biomaterial
Authors: Wang Hua‐Jie , Zhang Yue , Kato Shunji , Nakagawa Kiyotaka , Kimura Fumiko , Miyazawa Teruo , Wang Jin‐Ye 
Published: September 2017

AbstractGiven the inadequacies of existing clinic tracking strategies, such as isotopic tracer techniques, one of the major thrusts in protein‐based tissue engineering substitutes prior to use in clinic is to develop a safe technique that can effectively track their degradation in vivo. Keeping in view the possible application of a natural polymer, zein as a novel bone substitute, with the advantages of good bio‐compatibility, bio‐degradability and outstanding mechanical properties, we attempted here to construct a HPLC‐MS/MS method to track the in vivo degradation of zein porous scaffold. Histological observation and immunohistochemistry analysis using the intramuscular implantation model of rats clearly indicated that zein porous scaffold has certain osteoinductive ability. More importantly, HPLC‐MS/MS detected the changes of amino acids levels in plasma and different organs after the implantation of scaffolds. With these findings, it could be concluded that HPLC‐MS/MS might be a potential method to track the in vivo degradation of protein‐based tissue engineering substitutes. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 606–613, 2018.
Application of 2‐ and 3‐Dimensional Sonography Using the Virtual Organ Computer‐Aided Analysis Technique to Measure the Hippocampal Formation and Its Correlation With Corrected Gestational Age in Neonates
Authors: Chen Xiaokang , Hu Shiyin , Lv Guorong 
Published: September 2017

ObjectivesThe purpose of this study was to use transcranial 2‐ and 3‐dimensional sonography with the Virtual Organ computer‐aided analysis (GE Healthcare, Milwaukee, WI) technique to observe the morphologic characteristics of the hippocampal formation and to analyze its correlation with the corrected gestational age.MethodsTranscranial sonography was performed from the sagittal plane of the anterior fontanel to the sagittal plane of the posterior horn of the lateral ventricle. The morphologic characteristics of the hippocampal formation in 183 singleton neonates with a corrected gestational age of 32 to 43 weeks were observed. The long diameter, short diameter, area, and perimeter of the hippocampal formation were all quantitatively measured. The volume of the hippocampal formation was measured by 3‐dimensional sonography using the Virtual Organ computer‐aided analysis technique. The correlation between the corrected gestational age and each parameter was analyzed.ResultsThe display rate of the hippocampal formation was 100% in the neonates with a typical hippocampus shape. In healthy neonates with a corrected gestational age of 32 to 43 weeks, the long and short diameters, area, perimeter, and volume of the hippocampal formation were all positively correlated with the gestational age.ConclusionsTranscranial sonography could be used as a conventional approach for evaluation of the development of the hippocampal formation in neonates.
Use of Multiple Ultrasonographic Parameters in Confirmation of Carpal Tunnel Syndrome
Authors: Ažman Dražen , Hrabač Pero , Demarin Vida 
Published: September 2017

ObjectivesUltrasonography (US) of the median nerve has been increasingly studied and used for confirmation of carpal tunnel syndrome (CTS). However, a consensus on the choice of parameters to be evaluated is still not established. The aim of this diagnostic accuracy study was to assess the diagnostic value of multiple parameters individually, as well as in different combinations of variable complexity, and to find an optimal approach for US‐based confirmation of a CTS diagnosis.MethodsAll participants completed clinical and electrophysiologic evaluations, and their hands were scanned with a 5–13‐MHz linear US transducer. Eighty‐six patients with CTS (135 symptomatic hands) and 50 control participants (93 asymptomatic hands) were analyzed. The median nerve was recorded transversely at the forearm, at the carpal tunnel inlet, in the mid tunnel, and at the carpal tunnel outlet. For determining the parameters' diagnostic value, sensitivities, specificities, and area under the curve (AUC) values were calculated.ResultsThe inlet cross‐sectional area, inlet circumference, and outlet cross‐sectional area of the median nerve had the highest AUCs (0.962, 0.920, and 0.913, respectively), sensitivities (87.4%, 80.0%, and 74.1%), and specificities (94.6%, 91.4%, and 92.5%) among single‐measurement parameters. An analysis of 2‐level parameters (wrist‐to‐forearm‐ratio, inlet‐to‐outlet‐ratio, outlet‐to‐forearm‐ratio, and inlet‐outlet mean) yielded the highest AUC (0.974) for the mean cross‐sectional area of the median nerve [(inlet + outlet cross‐sectional area)/2], with high sensitivity (93.5%) and specificity (91.1%). A compound regression‐based index yielded a marginally higher AUC (0.989) than the previously mentioned parameters.ConclusionsResults of the study show that the mean cross‐sectional area and inlet cross‐sectional area may be valid and easy‐to‐acquire parameters for routine clinical use in confirming CTS.