bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors to improve the interobserver agreement for gastric atrophy and intestinal metaplasia: consensus of definition and criteria
Authors: Kim Sung Sun , Kook Myeong‐Cherl , Shin Ok‐ran , Kim Hee Sung , Bae Han‐Ik , Seo An Na , Park Do Youn , Choi Il Ju , Kim Young‐Il , Nam Byung Ho , Kim Sohee 
Published: November 2017

AimsIntestinal metaplasia and atrophy of the gastric mucosa are associated with Helicobacter pylori infection and are considered premalignant lesions. The updated Sydney system is used for these parameters, but experienced pathologists and consensus processes are required for interobserver agreement. We sought to determine the influence of the consensus process on the assessment of intestinal metaplasia and atrophy.Methods and resultsTwo study sets were used: consensus and validation. The consensus set was circulated and five gastrointestinal pathologists evaluated them independently using the updated Sydney system. The consensus of the definitions was then determined at the first consensus meeting. The same set was recirculated to determine the effect of the consensus. The second consensus meeting was held to standardise the grading criteria and the validation set was circulated to determine the influence. Two additional circulations were performed to assess the maintainance of consensus and intraobserver variability. Interobserver agreement of intestinal metaplasia and atrophy was improved through the consensus process (intestinal metaplasia: baseline κ = 0.52 versus final κ = 0.68, P = 0.006; atrophy: baseline κ = 0.19 versus final κ = 0.43, P < 0.001). Higher interobserver agreement in atrophy was observed after consensus regarding the definition (pre‐consensus: κ = 0.19 versus post‐consensus: κ = 0.34, P = 0.001). There was improved interobserver agreement in intestinal metaplasia after standardisation of the grading criteria (pre‐standardisation: κ = 0.56 versus post‐standardisation: κ = 0.71, P = 0.010).ConclusionsThis study suggests that interobserver variability regarding intestinal metaplasia and atrophy may result from lack of a precise definition and fine criteria, and can be reduced by consensus of definition and standardisation of grading criteria.
Gastrointestinal risk factors and prescribing pattern of antiulcer agents in patients taking low-dose aspirin in Japan
Authors: Iwasawa Makiko , Wada Kyoichi , Takada Mitsutaka 
Published: November 2017

Abstract

Objectives
To identify prescribing patterns of antiulcer agents in patients on low-dose aspirin (LDA) and to evaluate the number of gastrointestinal (GI) risk factors of the patients.

Methods
A retrospective chart review of patients taking LDA was conducted at the National Cerebral and Cardiovascular Center in Japan. The rate of concomitant use of antiulcer agents and the risk of each patient to develop GI complications were evaluated.

Results
Of the 314 patients, 64 were not on antiulcer agents and 55 of them had &gt;1 risk factor. More patients not on antiulcer agents had started LDA before hospitalization.

Conclusion
The rate of coprescribing antiulcer agents with LDA was high. However, the timing of initiating LDA therapy affected the prescribing pattern of antiulcer agents.
Leptin action in normal and pathological pregnancies
Authors: Pérez‐Pérez Antonio , Toro Ayelén , Vilariño‐García Teresa , Maymó Julieta , Guadix Pilar , Dueñas José L. , Fernández‐Sánchez Manuel , Varone Cecilia , Sánchez‐Margalet Víctor 
Published: November 2017

AbstractLeptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.
Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece
Authors: Charonis Aristidis S. , Michalak Marek , Groenendyk Jody , Agellon Luis B. 
Published: November 2017

AbstractStarting from 1994, every 2 years, an international workshop is organized focused on calreticulin and other endoplasmic reticulum chaperones. In 2017, the workshop took place at Delphi Greece. Participants from North and South America, Europe, Asia and Australia presented their recent data and discussed them extensively with their colleagues. Presentations dealt with structural aspects of calreticulin and calnexin, the role of Ca2+ in cellular signalling and in autophagy, the endoplasmic reticulum stress and the unfolded protein response, the role of calreticulin in immune responses. Several presentations focused on the role of calreticulin and other ER chaperones in a variety of disease states, including haemophilia, obesity, diabetes, Sjogren's syndrome, Chagas diseases, multiple sclerosis, amyotrophic lateral sclerosis, neurological malignancies (especially glioblastoma), haematological malignancies (especially essential thrombocythemia and myelofibrosis), lung adenocarcinoma, renal pathology with emphasis in fibrosis and drug toxicity. In addition, the role of calreticulin and calnexin in growth and wound healing was discussed, as well as the possible use of extracellular calreticulin as a marker for certain diseases. It was agreed that the 13th International Calreticulin Workshop will be organized in 2019 in Montreal, Quebec, Canada.
Salivary α‐amylase as a marker of stress reduction in individuals with intellectual disability and autism in response to occupational and music therapy
Authors: Poquérusse J. , Azhari A. , Setoh P. , Cainelli S. , Ripoli C. , Venuti P. , Esposito G. 
Published: November 2017

AbstractBackgroundAlthough the benefits of a range of disability‐centric therapies have been well studied, little remains known about how they work, let alone how to monitor these benefits in a precise and reliable way.MethodsHere, in two independent studies, we examine how sessions consisting of occupational or music therapy, both widely recognised for their effectiveness, modulate levels of salivary α‐amylase (sAA), a now time‐ and cost‐efficient marker of stress, in individuals with intellectual disability and autism spectrum disorder. Pre‐session and post‐session levels of sAA were compared in both groups in response to therapy and control sessions.ResultsIn comparison to control sessions, occupational therapy significantly dampened rises in sAA levels while music therapy significantly decreased baseline sAA levels, highlighting the ability of both types of therapy to reduce stress and by proxy contribute to enhancing overall well‐being.ConclusionsNot only do these results confirm the stress‐reducing nature of two types of multisensory therapy, but they support the use of sAA as a potential tool for evaluating stress levels in individuals with intellectual disability and autism spectrum disorder, providing an important physiological lens that may guide strategies in clinical and non‐clinical care for individuals with disabilities.
Delayed allergic hypersensitivity to hyaluronidase during the treatment of granulomatous hyaluronic acid reactions
Authors: Wu Lin , Liu Xiaoming , Jian Xingling , Wu Xia , Xu Ning , Dou Xia , Yu Bo 
Published: November 2017

SummaryHyaluronic acid (HA) is now extensively employed for esthetic concerns. In the majority of cases, HA is considered to be safe, but mild‐to‐severe complications can occur in a few cases. Hyaluronidase is enzymes that degrade HA, also being suggested for the treatment of HA filler‐induced complications. However, hyaluronidase has been reported to be a potential cause of allergic responses in some anesthetic and ophthalmic literature. However, there are few reports of allergic reactions to hyaluronidase in cosmetic medicine. We herein report on a 39‐year‐old Asian woman who developed a delayed allergic hypersensitivity to hyaluronidase in the treatment process of HA‐related granulomatous reaction.
Securely implementable social choice functions in divisible and nonexcludable public good economies with quasi‐linear utility functions
Authors: Nishizaki Katsuhiko 
Published: November 2017

AbstractThis paper studies the possibility of secure implementation (Saijo et al., 2007) in divisible and nonexcludable public good economies with quasi‐linear utility functions. In these economies, although Saijo et al. (2007) showed that the Groves mechanisms (Groves, 1973) are securely implementable when the valuation functions of the public good are (i) differentiable, concave, and (ii) identified with a real number, respectively, this paper shows the following negative result: securely implementable social choice functions are dictatorial or constant when the valuation functions of the public good are strictly increasing and strictly concave.
Association between height and periodontitis in Korean adults: Results from KNHANES IV and V
Authors: Shim S.‐H. , Han D.‐H. 
Published: November 2017

Background and objectiveEvidence shows that a short stature in adulthood is associated with chronic diseases. However, few studies have investigated the association between height and periodontitis. The purpose of this study was to examine the relationship between adult height and periodontitis and to assess the roles of covariates in different birth cohorts of Korea.Material and MethodsThis was a cross‐sectional study using the data from the 4th and 5th Korea National Health and Nutritional Examination Survey. The subjects were grouped into 2 birth cohorts based on their historical and social context: born from 1946 to 1962 and from 1963 to 1978. The dependent variables were periodontitis and severe periodontitis, while the independent variable was the height quartile. Demographic factors (age and gender), socioeconomic position (own education, region and income), health behaviors (frequency of daily tooth brushing and smoking) and medical status (diabetes) were included. Logistic regression analyses estimated the association of adult height with periodontitis after sequential adjustments.ResultsThe sample size of the final analysis was 18 010. The shortest quartile was associated with severe periodontitis (OR = 1.55, 95% CI 1.11‐2.16) in the 1963‐1978 birth cohort. The association remained after full adjustment in the 1963‐1978 birth cohort (OR = 1.41, 95% CI 1.01‐1.97).ConclusionOur study shows that there is an inverse association between height and severe periodontitis only in the younger Korean birth cohort. Our results support the impact of height, as an early childhood environmental indicator, on severe periodontitis in adulthood.
Environmental variables and diversity index as a tool for management in tropical man‐made lakes
Authors: Paul T. T. , Palaniswamy R. , Manoharan S. , Unnithan U. , Sarkar U. K. , Safeena P. K. 
Published: November 2017

AbstractFish and water samples were collected from various randomly situated sampling sites in two tropical man‐made lakes, Peechi and Pothundi reservoirs, in South India. The fish samples collected during 2014 to 2015 were taxonomically identified and the fish diversity indices of these reservoirs evaluated. The water samples collected were analysed for such environmental variables as pH, electrical conductivity, dissolved oxygen concentration, alkalinity, hardness, chlorophyll and nutrient concentrations. T‐tests indicated significant difference in both the fish diversity and environmental variables between these two reservoirs. The Pearson correlation test identified electrical conductivity as a highly correlated environmental variable to the ichthyodiversity index in Peechi and Pothundi reservoirs, with coefficients of 0.939 and 0.7012, respectively. Principal co‐ordinate analysis also was conducted on the variables to identify the best combination of variables subjective to the particular sampling site influencing the fish diversity. The analyses explained 72.8% of the total variations for Peechi reservoir, which was represented with eigenvalues of 7.53 and 3.393, respectively, for the first two dimensions. A similar analysis of Pothundi reservoir produced eigenvalues 7.05 and 3.01, respectively, for the first two dimensions, explaining 67.1% of the total inertia. The individual factor maps (IFM‐I and IFM‐II) for Peechi and Pothundi reservoirs identified a high diversity at sampling site 3 in Peechi reservoir, and a similar finding for sites 3 and 7 in Pothundi reservoir, being related to the interactions with other environmental variables, which were greatly influenced by the predominance of macrophytes. The latter is a characteristic of rainfed tropical reservoirs, with special reference to the native fish diversity and environmental variables. The findings of this study suggest management decisions for any aquatic system may be considered after prior assessment of environmental variables and the ichthyodiversity index of the indicated waterbody.
Juvenile mycosis fungoides with large‐cell transformation: Successful treatment with psoralen with ultraviolet A light, interferon‐alfa, and localized radiation
Authors: Chan Warren H. , Lewis Daniel J. , Hinojosa Tiffany , Curry Jonathan L. , Duvic Madeleine 
Published: November 2017

AbstractMycosis fungoides with large‐cell transformation is historically associated with a poor prognosis. Pediatric cases of mycosis fungoides with large‐cell transformation are rare, with only three other cases reported in the literature. We present the first case of a child with almost complete remission of his mycosis fungoides with large‐cell transformation shortly after administration of psoralen plus ultraviolet A, interferon‐alfa, and localized radiation.
Young athletes’ health knowledge system: Qualitative analysis of health learning processes in adolescent sportspersons
Authors: Rodríguez‐Serrano L. I. , Timpka T. , Ekberg J. , Dahlström Ö. , Jacobsson J. 
Published: November 2017

Recognized side effects on health associated with sports participation in youth include overtraining, doping, and exposure to harassment and violence. Many of these effects originate in contexts where young athletes are beginning to make decisions about their sports practices on their own. This study sets out to explore knowledge and reasoning about health among adolescent athletes and to describe how health knowledge management structures are associated with different social systems. Qualitative data were collected from focus groups involving 65 young Swedish athletes aged 16‐17 years. The participants’ knowledge and reasoning about health were examined using a deductive thematic analysis, categories from Bloom's taxonomy of educational objectives, and Luhmann's social systems theory. The meaning of health was found to have a dynamic character for the young athletes, associated with constantly striving to satisfy immediate needs and fulfill short‐time life goals. The athletes’ thinking about health was associated with a pragmatic “health‐as‐a‐resource” perspective, characterized by group self‐comparisons, rapid cognitive processing, and opportunistic substitutions. They expressed a particular interest in experiential learning and personally relevant procedural knowledge, and they perceived that their factual knowledge about health was saturated. The results of this study add emphasis to the importance of involving adolescent sportspersons in the development of health education programs and contextualizing the programs to the athletes’ specific age and social environment.
Asymmetry during Functional Movement Screening and injury risk in junior football players: A replication study
Authors: Chalmers S. , Debenedictis T. A. , Zacharia A. , Townsley S. , Gleeson C. , Lynagh M. , Townsley A. , Fuller J. T. 
Published: November 2017

An indicator of movement quality and potential injury risk during Functional Movement Screen (FMS) testing is the presence of asymmetry when comparing the left and right sides of the body. The aim of the study was to investigate the reproducibility of the injury risk model proposed in our previous research (Chalmers et al. 2017; derivation study) that showed an increased injury risk for elite junior Australian football players demonstrating ≥2 asymmetrical FMS subtests. We used a direct replication design. Players underwent pre‐season FMS testing, and an injury surveillance system monitored 277 male participants during the subsequent regular season competition. Designated club officials monitored the weekly competition participation of players. The definition of an injury was “a trauma or medical condition which caused a player to miss a competitive game”. Cox proportional hazards regression models were used to investigate the relationship between asymmetry and number of games played before first injury (ie, survival time). The level of reproducibility was determined according to statistical significance, effect size, and subjective assessment. Demonstrating asymmetry during FMS testing was not associated with a significant increase in prospective injury risk in the replication study (P > .05). Moreover, effect sizes (hazard ratios) from the derivation dataset were not within the 95% confidence intervals of the respective asymmetry predictor in the replication dataset. Subjectively, researchers were in agreement that the findings from the derivation data were not successfully reproduced. Clinicians and researchers should be cautious about using FMS asymmetry findings to derive injury risk for junior football players.
Effects of different endurance exercise modalities on migraine days and cerebrovascular health in episodic migraineurs: A randomized controlled trial
Authors: Hanssen H. , Minghetti A. , Magon S. , Rossmeissl A. , Rasenack M. , Papadopoulou A. , Klenk C. , Faude O. , Zahner L. , Sprenger T. , Donath L. 
Published: November 2017

Aerobic exercise training is a promising complementary treatment option in migraine and can reduce migraine days and improve retinal microvascular function. Our aim was to elucidate whether different aerobic exercise programs at high vs moderate intensities distinctly affect migraine days as primary outcome and retinal vessel parameters as a secondary. In this randomized controlled trial, migraine days were recorded by a validated migraine diary in 45 migraineurs of which 36 (female: 28; age: 36 (SD:10)/BMI: 23.1 (5.3) completed the training period (dropout: 20%). Participants were assigned (Strata: age, gender, fitness and migraine symptomatology) to either high intensity interval training (HIT), moderate continuous training (MCT), or a control group (CON). Intervention groups trained twice a week over a 12‐week intervention period. Static retinal vessel analysis, central retinal arteriolar (CRAE) and venular (CRVE) diameters, as well as the arteriolar‐to‐venular diameter ratio (AVR) were obtained for cerebrovascular health assessment. Incremental treadmill testing yielded maximal and submaximal fitness parameters. Overall, moderate migraine day reductions were observed ( = .12): HIT revealed 89% likely beneficial effects (SMD = 1.05) compared to MCT (SMD = 0.50) and CON (SMD = 0.59). Very large intervention effects on AVR improvement ( = 0.27), slightly favoring HIT (SMD=‐0.43) over CON (SMD=0), were observed. HIT seems more effective for migraine day reduction and improvement of cerebrovascular health compared to MCT. Intermittent exercise programs of higher intensities may need to be considered as an additional treatment option in migraine patients.
Influence of biceps brachii tendon mechanical properties on elbow flexor force steadiness in young and old males
Authors: Smart R. R. , Baudry S. , Fedorov A. , Kuzyk S. L. , Jakobi J. M. 
Published: November 2017

Elbow flexor force steadiness (FS) depends on strength and decreases with age. Achilles tendon mechanics effect standing balance and isometric plantarflexion FS. This study investigated the influence of distal biceps brachii (BB) tendon mechanics and elbow flexor strength on age‐related decline in FS. Nine young (23 ± 2 years) and nine old (77 ± 5 years) males performed submaximal isometric elbow flexion tasks at low (2.5%, 5%, 10% maximal voluntary contraction (MVC)) and high (20%, 40%, 60%, 80%MVC) forces in a neutral forearm position. Distal BB tendon elongation and cross‐sectional area (CSA) were recorded on ultrasound to calculate mechanics of strain, stress, and stiffness. Coefficient of variation (CV) of force was used to assess relationship of FS to tendon mechanics and strength. Young were 22% stronger and 41% steadier than old (P < .05). Tendon stiffness (170.1 ± 132.9 N/mm; 113.0 ± 55.1 N/mm) did not differ with age (P > .05). Young had 40% less strain compared to old at 5% MVC, but 42% greater strain at 60% and 80% MVC (P ≤ .05). Stress was ~18% greater in young at 10%, 20%, and 80% MVC (P ≤ .05). At low forces, CV of force was predicted by stress (r2 = 0.56) in young, and stress and MVC (r2 = 0.641) in old. At high forces for both age groups, CV of force was predicted by MVC and stress (r2 = 0.39‐0.43). Stress and strain is greater in young compared with old males. Because strength influences tendon mechanics and is also associated with FS, absolute strength is a large and modifiable contributor to age‐related decline in FS.
Low sensitivity and frequent cross‐reactions in commercially available antibody detection ELISA assays for Taenia solium cysticercosis
Authors: Garcia Hector H. , Castillo Yesenia , Gonzales Isidro , Bustos Javier A. , Saavedra Herbert , Jacob Louis , Del Brutto Oscar H. , Wilkins Patricia P. , Gonzalez Armando E. , Gilman Robert H. ,   the Cysticercosis Working Group in Peru
Published: November 2017

AbstractObjectiveTo evaluate the diagnostic performance of two commercially available ELISA kits, Novalisa® and Ridascreen®, for the detection of antibodies to Taenia solium, compared to serological diagnosis of neurocysticercosis (NCC) by LLGP‐EITB (electro‐immunotransfer blot assay using lentil‐lectin purified glycoprotein antigens).MethodsArchive serum samples from patients with viable NCC (n = 45) or resolved, calcified NCC (n = 45), as well as sera from patients with other cestode parasites (hymenolepiasis, n = 45 and cystic hydatid disease, n = 45), were evaluated for cysticercosis antibody detection using two ELISA kits, Novalisa® and Ridascreen®. All NCC samples had previously tested positive, and all samples from heterologous infections were negative on LLGP‐EITB for cysticercosis. Positive rates were calculated by kit and sample group and compared between the two kits.ResultsCompared to LLGP‐EITB, the sensitivity of both ELISA assays to detect specific antibodies in patients with viable NCC was low (44.4% and 22.2%), and for calcified NCC, it was only 6.7% and 4.5%. Sera from patients with cystic hydatid disease were highly cross‐reactive in both ELISA assays (38/45, 84.4%; and 25/45, 55.6%). Sera from patients with hymenolepiasis cross‐reacted in five cases in one of the assays (11.1%) and in only one sample with the second assay (2.2%).ConclusionsThe performance of Novalisa® and Ridascreen® was poor. Antibody ELISA detection cannot be recommended for the diagnosis of neurocysticercosis.