bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current State of Connected Sensor Technologies Used During Rehabilitation Care: Protocol for a Scoping Review
Authors: Rauzi Michelle R , Akay Rachael B , Balakrishnan Swapna , Piper Christi , Gobert Denise , Flach Alicia 
Published: September 2024

Background
Connected sensor technologies can capture raw data and analyze them using advanced statistical methods such as machine learning or artificial intelligence to generate interpretable behavioral or physiological outcomes. Previous research conducted on connected sensor technologies has focused on design, development, and validation. Published review studies have either summarized general technological solutions to address specific behaviors such as physical activity or focused on remote monitoring solutions in specific patient populations.

Objective
This study aimed to map research that focused on using connected sensor technologies to augment rehabilitation services by informing care decisions.

Methods
The Population, Concept, and Context framework will be used to define inclusion criteria. Relevant articles published between 2008 to the present will be included if (1) the study enrolled adults (population), (2) the intervention used at least one connected sensor technology and involved data transfer to a clinician so that the data could be used to inform the intervention (concept), and (3) the intervention was within the scope of rehabilitation (context). An initial search strategy will be built in Embase; peer reviewed; and then translated to Ovid MEDLINE ALL, Web of Science Core Collection, and CINAHL. Duplicates will be removed prior to screening articles for inclusion. Two independent reviewers will screen articles in 2 stages: title/abstract and full text. Discrepancies will be resolved through group discussion. Data from eligible articles relevant to population, concept, and context will be extracted. Descriptive statistics will be used to report findings, and relevant outcomes will include the type and frequency of connected sensor used and method of data sharing. Additional details will be narratively summarized and displayed in tables and figures. Key partners will review results to enhance interpretation and trustworthiness.

Results
We conducted initial searches to refine the search strategy in February 2024. The results of this scoping review are expected in October 2024.

Conclusions
Results from the scoping review will identify critical areas of inquiry to advance the field of technology-augmented rehabilitation. Results will also support the development of a longitudinal model to support long-term health outcomes.

Trial Registration
Open Science Framework jys53; https://osf.io/jys53

International Registered Report Identifier (IRRID)
DERR1-10.2196/60496
Efficacy and Safety of a Therapy Combining Sintilimab and Chemotherapy With Cryoablation in the First-Line Treatment of Advanced Nonsquamous Non–Small Cell Lung Cancer: Protocol for a Phase II, Pilot, Single-Arm, Single-Center Study
Authors: Gao Zhiqiang , Teng Jiajun , Qiao Rong , Qian Jialin , Pan Feng , Ma Meili , Lu Jun , Zhang Bo , Chu Tianqing , Zhong Hua 
Published: September 2024

Background
Immunotherapy has significantly advanced lung cancer treatment, particularly in nonsquamous non–small cell lung cancer (NSCLC), with overall response rates between 50% and 60%. However, about 30% of patients only achieve a stable disease state. Cryoablation has shown potential to enhance immunotherapy by modifying the tumor’s immune microenvironment through the release of antigens and immune factors. Addressing how to boost the immune response in these patients is critical.

Objective
This study aims to investigate the efficacy and safety of immunochemotherapy in combination with cryoablation as a first-line treatment for advanced NSCLC.

Methods
This is a phase II, pilot, open-label, single arm, single center, interventional study. Patients with stage IIIB to IIIC or IV NSCLC with T staging ranging from T1 to T2b will receive sintilimab (200 mg/m2 every 3 weeks) and chemotherapy. After 2 cycles, the feasibility of cryoablation will be considered for those with stable disease by a multidisciplinary team. Cryoablation with 3 freeze-thaw cycles will be performed for the main lesion. The third cycle of systemic therapy will begin 7 (SD 3) days after cryoablation. A total of 20 patients will be enrolled. Treatment will continue until the disease progresses, there is unacceptable toxicity, a participant withdraws consent, other discontinuation criteria are met, or the study reaches completion. The primary objective is to assess progression-free survival (PFS). The secondary objective is to assess efficacy through duration of response, disease control rate, overall survival (OS), and the safety profile. The exploratory objective is to investigate and compare immune factor changes after 2 cycles of immunochemotherapy and at 1, 3, and 7 days after cryoablation. Survival time will be estimated using the Kaplan-Meier method to calculate median PFS and OS. Any adverse events that occur during the trial will be promptly recorded.

Results
The project was funded in 2024, and enrollment will be completed in 2025. The first results are expected to be submitted for publication in 2027.

Conclusions
This study will provide evidence for the efficacy and safety of the combination of immunochemotherapy and cryoablation as a first-line treatment for advanced NSCLC. Although it has a limited sample size, the findings of this study will be used in the future to inform the design of a fully powered, 2-arm, larger-scale study.

Trial Registration
ClinicalTrials.gov NCT06483009; https://clinicaltrials.gov/study/NCT06483009

International Registered Report Identifier (IRRID)
PRR1-10.2196/64950
On the Ethics of Real-Life Examples of Argument
Authors: Aikin Scott F. 
Published: September 2024

Argumentation theorists know that their work has real-life application, and similarly, they draw inspiration for that work from real-life experiences. Sometimes, it comes from some public medium – the newspaper, a blog, a debate stage. But we also draw from more private reason-exchanges – a conversation with a neighbor, small-talk with a colleague, or a lovers’ spat. A few worries about publicly theorizing about those more private cases arise. We may be making public something that was unguarded, and so betray a trust. Our theoretical reflections may themselves warp the relationship we’d originally savored, particularly when our partners know about the possibility of them being publicly scrutinized. Novelists and poets regularly struggle with this challenge with their work, and we argumentation theorists should, too.

Les théoriciens de l’argumentation savent que leur travail a des applications concrètes et, de la même manière, ils s’inspirent d’expériences réelles. Parfois, ces idées proviennent d’un média public – un journal, un blog, une tribune de débat. Mais nous nous inspirons aussi d’échanges de raisonnement plus privés – une conversation avec un voisin, une petite conversation avec un collègue ou une dispute amoureuse. Nous craignons de théoriser publiquement sur ces cas plus privés. Nous pouvons rendre public des commentaires irréfléchis et ainsi trahir une confiance. Nos réflexions théoriques peuvent déformer la relation que nous avions initialement très appréciée, en particulier lorsque nos partenaires savent qu’ils peuvent être scrutés publiquement. Les romanciers et les poètes sont régulièrement confrontés à ce défi dans leur travail, et nous, les théoriciens de l’argumentation, devrions également le faire.
ANALISIS PENGELOLAAN KONTEN MEDIA SOSIAL PT TRANSPORTASI JAKARTA DALAM MEMBENTUK BRAND AWARENESS (Studi Kasus pada Instagram @pt_transjakarta)
Authors: Adriany Novira Wieke 
Published: September 2024

The rapid development of technology has brought many benefits to many aspects of life, one of them is the rise of the Internet or digitalization. This study examines Social Media Content Management Analysis of PT Transportasi Jakarta in Forming Brand Awareness. The purpose of this study is to see the effectiveness of the management of social media content of PT Transportation Jakarta, in particular instagram carried out by PT Transportasi Jakarta against brand awareness of PT Transportasi Jakarta. This research uses a qualitative approach with case study methods. The data collection technique was conducted using interviews as well as supporting documents related to content management on the instagram media @pt_transjakarta. The results of this study show that the wider public has been aware of the services of PT Transportation Jakarta and the content produced today has the diversity to reach more people. However, the public expects Transjakarta to provide more frequently content in the form of information about its route services or operations. Keywords: social media content management, social media, brand awareness
Critical assessment of a cancer/oncology journal that suddenly ceased publication: Journal of the Balkan Union of Oncology
Authors: Teixeira da Silva Jaime A. 
Published: September 2024

Abstract
This article provides a brief historical overview of a now-shuttered open access cancer/oncology journal, Journal of the Balkan Union of Oncology (JBUON), whose metrics peaked with a 2020 Clarivate Analytics journal impact factor of 2.533. JBUON suddenly ceased publication in December 2021. The scrutiny of JBUON papers of this PubMed-indexed journal at the post-publication website PubPeer revealed a myriad of ethical infractions and the likely association with paper mills. In addition to troubling information about JBUON’s publishing operations, this paper emphasizes the opaque manipulation of the content of an unknown number of papers, a procedure that is considered unscholarly, dishonest, or even predatory. The fatal publishing errors and mismanagement of this journal that led to its demise serve as a useful learning curve for other cancer/oncology journals that may feel tempted to manipulate the scholarly record, either to “save face” or give the impression of an error-free publication record.
The Power Dynamical Dissolution of the Logical Problem of Evil and a Foundational “Substance” for Metaethics
Authors: Curtis Paul 
Published: September 2024

Abstract
This paper aims to show that the traditional problem of evil can be logically dissolved by a more thorough analysis of what love (Agape, Eros, Philia) and evil actually are. When investigated this analysis reveals that they are manifestations and evaluations of power dynamical relations leading to a conclusion that it would be logically impossible for God to be all-loving and at the same time prevent evil as all-loving constitutes an unlimited, unjudgmental, empowerment and good and evil are simply evaluations or perspectives on that power use. To stop evil God would have to disempower in some way and that would not be Agape and thus logically impossible as Agape is part of the very nature of God. This paper reveals the “form” of good to be empowerment and the “form” of bad/evil to be disempowerment.
The Problem of Evil and the Simulation Hypothesis
Authors: Facal Christophe 
Published: September 2024

Abstract
I argue that the Problem of Evil diminishes the likelihood of the simulation hypothesis being true. In section 1, I present the simulation hypothesis. In section 2, I present the Problem of Evil and how it can be addressed to the simulation hypothesis. In section 3, I strengthen my claim by defending the idea that, on the grounds of the expansion of the moral circle, we can infer that potential simulators would most probably view simulated beings as moral subjects. Section 4 is dedicated to counterarguments and their responses, and section 5 contains a conclusion where I clarify the probabilistic nature of my argument.
The Burden of Philosophy: Evil and the Human Condition
Authors: Kanterian Edward 
Published: September 2024

Abstract
This article attempts to identify certain shortcomings in analytic philosophy as practised today. First, it identifies a disconnect between the darker aspects of the human condition and philosophers’ inability to engage with them. Second, it locates this inability in a certain logic of detachment, explored by Peter Strawson. Third, it points out problems with Strawson’s analysis, which it then tries to overcome, using Constantin Noica’s account of the Platonising attitude philosophers are perennially tempted by – one of several ways in which humans try to overcome their fallen condition. This is contrasted with Thomas Nagel’s valuable but still deficient discussion of the “cosmic question”. This brings us, finally, to a reconsideration of an older tradition in philosophy, which focused more explicitly on human fallenness. Petrarch’s Secretum meum is used as an example to show that while the failure of analytic philosophers has deep existential roots, it is not commendable. Philosophers must learn, again, to reflect on the darkness of the human soul – their own darkness.
“The Power of the One Needs the Stupidity of the Other.”1 Bonhoeffer’s Theory of Stupidity and Analysis of its Socio-political Impact
Authors: Răpcianu Ilie 
Published: September 2024

Abstract
Stupidity is a greater evil than evil itself. This could be the synthesis of the theory put forward by Dietrich Bonhoeffer. He was a Protestant pastor, theologian, counter-intelligence officer, and martyr, whose work decisively influenced the subsequent evolution of the relationship between society and theology. One of the most fascinating aspects of his thinking is represented by the theorization of stupidity, which appears in his meditation “After Ten Years,” where he outlines the disastrous consequences of human stupidity, as well as how stupidity – as a form of legitimizing evil – can be stopped. The greatest evil that society must confront is imbecility. But what is its connection to political (or radical) evil, and how can we stop its disastrous consequences?
Produktivitätsparadoxon der Digitalisierung im Krankenhaus – auf der Suche nach effizienzsteigernden Innovationen
Authors: Reif Simon , Bolz Theresa , Karamik Yasemin 
Published: September 2024

Abstract
The productivity paradox of digitisation in hospitals refers to the difficulty in realising measurable efficiency gains from digital innovations. Despite significant investments, healthcare costs continue to rise, particularly in OECD countries like Germany. While digitisation is expected to enhance efficiency, empirical evidence for substantial productivity improvements remains limited. This study analyses data from the European Hospital Survey and finds no clear correlation between hospitals’ digital integration and operational efficiency. It remains uncertain whether current policy efforts to increase health care digitalisation will yield the desired efficiency gains. More robust evidence to identify innovations that genuinely improve healthcare efficiency is needed to avoid cuts to available care for individuals in the social health insurance.
Suche nach einer stabilen, verlässlichen und solidarischen Finanzierung der gesetzlichen Krankenversicherung
Authors: Greiner Wolfgang , Witte Julian , Gensorowsky Daniel 
Published: September 2024

Abstract
The German Federal Government has initiated key projects and reforms for the future development of healthcare in Germany. These include political initiatives for deregulation, digitisation, and large-scale structural projects. However, rather than directly contributing to the relief of the financial situation in the statutory health insurance (SHI), these initiatives inherently require investment and increased expenditure. It is therefore imperative that stabilisation of the SHI finances accompany structural healthcare reforms. Therefore, sustainable development of the SHI must include transparency about reform options, reliable data on their expected effects, and the will to critically evaluate them.
Reform der deutschen Notfallversorgung – was möglich ist und dabei auf dem Spiel steht
Authors: Molzberger Kaspar 
Published: September 2024

Abstract
The German healthcare system faces urgent challenges, with Minister Karl Lauterbach proposing two major reforms: restructuring hospital financing and overhauling emergency services. While past efforts to reform emergency care have failed, the current crisis – exacerbated by staff shortages and increased demand – has intensified calls for change. However, the complexity of Germany’s decentralised system and competing interests among federal, state and local governments, and service providers hinder progress. The Minister’s plan includes integrated emergency centres and improved coordination between hospital and pre-hospital acute care. Achieving these goals, however, remains fraught with legal and political obstacles.
Bunte Karte, bunte Wahlen? AfD-Präferenzen jenseits von Ost und West
Authors: Kopka Alexander , Runst Petrik 
Published: September 2024

Abstract
The sharp East-West difference that emerges in the cartographic representation of regional election results changes significantly once regional-specific characteristics are controlled for. The higher preference for the right-wing party AfD becomes less sharply delineated between East and West after accounting for these factors. Instead, we find patterns where certain regions in southern Germany display an increased share of AfD supporters. Nonetheless, there remains a stronger preference for the AfD in the East compared to other parts of the country. The remaining difference can be interpreted as a divergence in culturally influenced values.
Die politische Ökonomie des Parteiensystems
Authors: Adam Hermann 
Published: September 2024

Abstract
In the first three post-war decades, the party system in the old Federal Republic was concentrated on the two major popular parties, the CDU/CSU and the SPD, and there was a great deal of satisfaction with democracy. In the following decades, the 2.5-party system became a six-party system. This article analyses the economic background of this development. It comes to the conclusion that high growth rates with noticeably rising real incomes led to the concentration, while low growth rates and stagnation or falling real incomes led to the fragmentation of the party system.
Steuerrabatt für neu Zugewanderte: Was ist zu erwarten, worauf kommt es an?
Authors: Brücker Herbert , Kosyakova Yuliya , Weber Enzo 
Published: September 2024

Abstract
The German Government’s growth initiative aims to strengthen immigration into the labour market. In the first three years, 30 %, 20 % and 10 % of the gross income of newly arrived skilled workers will be tax-free. The target group has not yet been precisely defined, but it is likely to be workers with professional and university qualifications under the Residence Act. This Act focuses on the immigration of skilled workers, including the EU Blue Card and the regulations for IT specialists. Under certain conditions, tax rebates can trigger additional migration. However, there are also disadvantageous deadweight and distributional effects. The aim must be to avoid a race to the bottom between international tax rates.
One Zins Fits All? Die Gratwanderung der EZB
Authors: Hungerland Wolf-Fabian 
Published: September 2024

Abstract
This paper analyses the European Central Bank’s (ECB) challenge in applying a uniform interest rate across the economically diverse Eurozone using the Taylor Rule. The analysis reveals that the ECB’s one-size-fits-all interest rate often fails to align with the economic conditions of individual member states, leading to periods of overly restrictive or loose monetary policy, especially noticeable during significant events like the global financial and euro crisis and during the recent inflation spike. The findings suggest a significant mismatch between the ECB’s actual rates and those recommended by the Taylor Rule, with the discrepancies largely dependent on the assumed natural interest rate. The analysis reveals that varying assumptions about the natural rate significantly affect the perceived appropriateness of the ECB’s policies, and that only the inclusion of monetary policy instruments beyond the interest rate help explain these findings.
Etanercept induced erectile dysfunction
Authors: Sonmez Ozge , Ugurlu Serdal 
Published: September 2024

Background:
Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial spine. Etanercept is a Tumor necrosis factor-alpha inhibitor (anti-TNF) that is widely used in the treatment of AS. The most common side effects of etanercept are infection, rash, and injection site reaction. Here, we reported an adverse event probably associated with etanercept.

Case Presentation:
A 30-year-old male patient with AS initiated etanercept due to uncontrolled back pain despite adequate doses of non-steroidal anti-inflammatory drugs. He developed erectile dysfunction (ED) within 1 month of etanercept treatment. ED disappeared after switching to secukinumab.

Conclusion:
There is limited data on the potential effects of anti-TNF on sexual function. ED might be a rare side effect of etanercept that resolves upon discontinuation of the drug. Secukinumab might be considered as an option in case of etanercept-induced ED. Even though ED is not a life-threatening side effect, switching medications could significantly improve patients’ quality of life.
Hematological parameters in patients with internal carotid artery atherosclerotic stenosis during tooth extraction.
Authors: Танашян М.М. , Максимова М.Ю. , Ройтман Е.В. 
Published: September 2024

Введение. Основой профилактики нарушений мозгового кровообращения у пациентов с атеросклерозом внутренней сонной артерии (ВСА) является непрерывная антиагрегантная терапия. Цель исследования: изучить характер изменений гематологического статуса при проведении экстракции зубов у пациентов с атеросклеротическим стенозом ВСА без отмены ацетилсалициловой кислоты (АСК). Материалы и методы. Проведено проспективное сравнительное исследование. Исходно, через 2 ч и 48 ч после экстракции зубов у 34 пациентов с атеросклеротическим стенозом ВСА исследовали основные показатели жизненно важных функций (артериальное давление, частоту сердечных сокращений, температуру тела, адекватность оксигенации), параметры общего анализа крови и коагулограммы, содержание D-димера и фактора фон Виллебранда. Результаты. Через 2 ч после экстракции зубов отмечено повышение содержания фибриногена и фактора фон Виллебранда, снижение значений активированного частичного тромбопластинового времени, протромбинового и тромбинового времени с последующим достижением исходных уровней через 48 ч. Заключение. Экстракция зубов у пациентов с атеросклерозом ВСА предполагает соблюдение непрерывного режима приема АСК.
Introduction. The foundation of acute cerebrovascular event prevention in patients with internal carotid artery (ICA) atherosclerosis is a continuous antiaggregant therapy. Aim: to study changes in the nature of hematological status during tooth extraction in patients with ICA atherosclerotic stenosis without discontinuation of acetylsalicylic acid (ASA). Materials and Methods. A prospective comparative study was conducted. The examination was conducted 2 hours and 48 hours after tooth extraction in 34 patients with ICA atherosclerotic stenosis, which included the evaluation of the main parameters of vital signs (blood pressure, heart rate, body temperature, adequacy of oxygenation), parameters of a general blood test and coagulogram, D-dimer and von Willebrand factor levels. Results. Two hours following tooth extraction, an increase in fibrinogen and von Willebrand factor levels was noted accompanied by a decrease in activated partial thromboplastin time, prothrombin time, and thrombin time. These changes were observed to return to baseline levels after 48 hours. Conclusion. In patients with ICA atherosclerosis, a continuous regimen of ASA use is essential for the safe and effective tooth extraction.