bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies
Authors: Tangye Stuart G. , Pelham Simon J. , Deenick Elissa K. , Ma Cindy S. 
Published: September 2017

Abstract
Cytokine-mediated intracellular signaling pathways are fundamental for the development, activation, and differentiation of lymphocytes. These distinct processes underlie protection against infectious diseases after natural infection with pathogens or immunization, thereby providing the host with long-lived immunological memory. In contrast, aberrant cytokine signaling can also result in conditions of immune dysregulation, such as early-onset autoimmunity. Thus, balanced signals provided by distinct cytokines, and delivered to specific cell subsets, are critical for immune homeostasis. The essential roles of cytokines in human immunity have been elegantly and repeatedly revealed by the discovery of individuals with mutations in cytokine ligands, receptors, and downstream transcription factors that cause primary immunodeficiency or autoimmune conditions. In this article, we review how the discovery and characterization of such individuals has identified nonredundant, and often highly specialized, functions of specific cytokines and immune cell subsets in human lymphocyte biology, host defense against infections, and immune regulation.
Earthquake static stress transfer in the 2013 Gulf of Valencia (Spain) seismic sequence
Authors: Saló Lluís , Frontera Tànit , Goula Xavier , Pujades Luis G. , Ledesma Alberto 
Published: September 2017

Abstract. On 24 September 2013, an Ml 3.6 earthquake struck in the Gulf of Valencia (Spain) near the Mediterranean coast of Castelló, roughly 1 week after gas injections conducted in the area to develop underground gas storage had been halted. The event, felt by the nearby population, led to a sequence build-up of felt events which reached a maximum of Ml 4.3 on 2 October.Here, we study the role of static stress transfer as an earthquake-triggering mechanism during the main phase of the sequence, as expressed by the eight felt events. By means of the Coulomb failure function, cumulative static stress changes are quantified on fault planes derived from focal mechanism solutions (which act as both source and receiver faults) and on the previously mapped structures in the area (acting only as stress receivers in our modeling). Results suggest that static stress transfer played a destabilizing role and point towards an SE-dipping structure underlying the reservoir (or various with analogous geometry) that was most likely activated during the sequence. One of the previously mapped faults could be geometrically compatible, yet our study supports deeper sources. Based on this approach, the influence of the main events in the occurrence of future and potentially damaging earthquakes in the area would not be significant.
Some generating functions and properties of extended second Appell function
Authors: Parmar Rakesh K. , Purohit Sunil Dutt 
Published: September 2017

Various families of generating functions have been established by a number of authors in many different ways. In this paper, we aim at establishing (presumably new) a generating function for the extended second Appell hypergeometric function $F_{2} (a, b, b'; c, c'; x, y; p)$. Further we derive a relation in terms of the Laguerre polynomials and differentiation formulas. We also present special cases of the main results of this paper.
Estratégias de visibilidade e ações docentes no Twitter
Authors: Santana Camila Lima Santana e , Couto Edvaldo Souza 
Published: September 2017

O artigo resulta de uma pesquisa que analisou estratégias de visibilidade e ações docentes utilizadas por professores brasileiros no Twitter. Trata-se de um estudo qualitativo, de cunho netnográfico, realizado através de observação encoberta e análise de tweets de um grupo que possui conta ativa no Twitter. O argumento central é que a visibilidade no Twitter é um capital social forjado por meio das estratégias que os sujeitos instituem nos Sites de Redes Sociais. Esse capital é singular, considerando que estar ativamente na rede, opinando, tecendo considerações, compartilhando, constitui-se ação educativa e resulta em valorização social e econômica. O estudo conclui que a visibilidade mediada no Twitter é uma forma de alcançar valorização social na dimensão docente, pois alcançar visibilidade é acumular tipos de capital social, sendo, portanto, uma estratégia profissional.
El bloqueo, evitable, de la formación del Gobierno: una propuesta de reforma del procedimiento de investidura
Authors: Giménez Gluck David 
Published: September 2017

Resumen:En el año 2016 nuestro sistema institucional sufrió un prolongado bloqueo, al no ser capaz de formar un Gobierno. Dicho bloqueo se debió, principalmente, a factores relacionados con la coyuntura política. Sin embargo, también puso en evidencia que la regulación constitucional del proceso de investidura es francamente mejorable.Una mirada al Derecho comparado nos enseña que otros sistemas han sido capaces de evitar el bloqueo del procedimiento de formación del Gobierno en situaciones políticas parecidas a la nuestra. Tras el estudio de lo recogido en otros países, el artículo propone una reforma constitucional centrada en dotar de mayor margen de maniobra a la institución que propone el candidato a Presidente del Gobierno, en establecer plazos que acoten el proceso y en cambiar el sistema de votación de la investidura. El objetivo de la propuesta es dotar a nuestro sistema constitucional de instrumentos para evitar que se repita en un futuro próximo el bloqueo que hemos vivido.Abstract:In 2016 our institutional system suffered a prolonged blockade, not be able to form a Government. This was due, mainly, to factors related with the political situation. However, it also put in evidence that the constitutional regulation of the process of investiture can be improved. A look at the comparative law teaches us that other systems have been able to avoid the blocking of the procedure for Government formation in political situations similar to ours. After the study of others countries regulation, the article proposes a constitutional reform focused on improving maneuverability to the institution that proposes the candidate to be President of the Government, in establishing deadlines that delimit the process and in changing the system of voting of the investiture. The purpose of the proposal is to provide to our constitutional system instruments to avoid, in the near future, a repetition of the lock that we experienced.
Making Sanctuary for the Divine: Exploring Melissa Raphael’s Holocaust Theology
Authors: Pramuk Christopher 
Published: September 2017

This article details the author’s experience introducing Melissa Raphael’s 2003 book, The Female Face of God in Auschwitz: A Jewish Feminist Theology of the Holocaust, to predominantly Christian undergraduate and graduate theology students, and makes the case that her work deserves greater attention in Catholic and Christian theological circles. In provocative ways that elude systematic categorization, Raphael’s sensitive retrieval and theological interpretation of death-camp narratives builds a bridge between the Jewish and Christian memory of God that comes to bear especially on the theodicy question as intensified in the suffering of women, children, and the planet Earth. The mystical and theopoetical character of Raphael's method finds deep, if unsettling, resonance in students from widely diverse backgrounds.
Misdiagnosis of HIV infection during a South African community‐based survey: implications for rapid HIV testing
Authors: Kufa Tendesayi , Kharsany Ayesha BM , Cawood Cherie , Khanyile David , Lewis Lara , Grobler Anneke , Chipeta Zawadi , Bere Alfred , Glenshaw Mary , Puren Adrian 
Published: September 2017

AbstractIntroduction: We describe the overall accuracy and performance of a serial rapid HIV testing algorithm used in community‐based HIV testing in the context of a population‐based household survey conducted in two sub‐districts of uMgungundlovu district, KwaZulu‐Natal, South Africa, against reference fourth‐generation HIV‐1/2 antibody and p24 antigen combination immunoassays. We discuss implications of the findings on rapid HIV testing programmes.Methods: Cross‐sectional design: Following enrolment into the survey, questionnaires were administered to eligible and consenting participants in order to obtain demographic and HIV‐related data. Peripheral blood samples were collected for HIV‐related testing. Participants were offered community‐based HIV testing in the home by trained field workers using a serial algorithm with two rapid diagnostic tests (RDTs) in series. In the laboratory, reference HIV testing was conducted using two fourth‐generation immunoassays with all positives in the confirmatory test considered true positives. Accuracy, sensitivity, specificity, positive predictive value, negative predictive value and false‐positive and false‐negative rates were determined.Results: Of 10,236 individuals enrolled in the survey, 3740 were tested in the home (median age 24 years (interquartile range 19–31 years), 42.1% males and HIV positivity on RDT algorithm 8.0%). From those tested, 3729 (99.7%) had a definitive RDT result as well as a laboratory immunoassay result. The overall accuracy of the RDT when compared to the fourth‐generation immunoassays was 98.8% (95% confidence interval (CI) 98.5–99.2). The sensitivity, specificity, positive predictive value and negative predictive value were 91.1% (95% CI 87.5–93.7), 99.9% (95% CI 99.8–100), 99.3% (95% CI 97.4–99.8) and 99.1% (95% CI 98.8–99.4) respectively. The false‐positive and false‐negative rates were 0.06% (95% CI 0.01–0.24) and 8.9% (95% CI 6.3–12.53). Compared to true positives, false negatives were more likely to be recently infected on limited antigen avidity assay and to report antiretroviral therapy (ART) use.Conclusions: The overall accuracy of the RDT algorithm was high. However, there were few false positives, and the sensitivity was lower than expected with high false negatives, despite implementation of quality assurance measures. False negatives were associated with recent (early) infection and ART exposure. The RDT algorithm was able to correctly identify the majority of HIV infections in community‐based HIV testing. Messaging on the potential for false positives and false negatives should be included in these programmes.
The contribution of NintendoWii Fitseries in the field of health: a systematic review and meta-analysis
Authors: Tripette Julien , Murakami Haruka , Ryan Katie Rose , Ohta Yuji , Miyachi Motohiko 
Published: September 2017

BackgroundWii Fitwas originally designed as a health and fitness interactive training experience for the general public. There are, however, many examples ofWii Fitbeing utilized in clinical settings. This article aims to identify the contribution ofWii Fitin the field of health promotion and rehabilitation by: (1) identifying the health-related domains for which theWii Fitseries has been tested, (2) clarifying the effect ofWii Fitin those identified health-related domains and (3) quantifying this effect.MethodA systematic literature review was undertaken. The MEDLINE database andGames for Health Journalpublished content were explored using the search term “Wii-Fit.” Occurrences resulting from manual searches on Google and material suggested by experts in the field were also considered. Included articles were required to have measurements fromWii Fitactivities for at least one relevant health indicator. The effect ofWii Fitinterventions was assessed using meta-analyses for the following outcomes: activity-specific balance confidence score, Berg balance score (BBC) and time-up-and-go test (TUG).FindingsA total of 115 articles highlighted that theWii Fithas been tested in numerous healthy and pathological populations. Out of these, only a few intervention studies have focused on the prevention of chronic diseases. A large proportion of the studies focus on balance training (N= 55). This systematic review highlights several potential benefits ofWii Fitinterventions and these positive observations are supported by meta-analyses data (N= 25). For example, the BBC and the TUG respond to a similar extend toWii Fitinterventions compared with traditional training.ConclusionWii Fithas the potential to be used as a rehabilitation tool in different clinical situations. However, the current literature includes relatively few randomized controlled trials in each population. Further research is therefore required.
Hierarchically Structured CuNiP/CuOx‐VP Nanoarrays Construction by Heteroatom Doping Boosting Glycerol Valorization at Industrial‐Level Current Density
Authors: Zheng Yue , Kang Zihu , Li Haotong , Song Xiangfei , Zhang Wanqi , Wang Gengchen , Tao Xia 
Published: October 2024

AbstractElectrocatalytic valorization of glycerol to formate is considered to be a promising sustainable approach; however, it holds great challenges to increase catalyst activity and deliver market‐demanded chemicals with high Faradaic efficiency (FE) and selectivity under industrial‐level current density. Herein, hierarchically structured phosphorus vacancy‐enriched nickel phosphide porous nanoarrays by copper doping, denoted as CuNiP/CuOx‐VP, are constructed via a facile glycol‐mediated solvothermal approach. The CuNiP/CuOx‐VP yields an industry‐level 1 A cm−2 at the ultralow potential of 1.75 V, while showing notable FE (96.94%) and selectivity (96.76%) to formate over a wide range of potentials. Impressively, a two‐electrode electrolyzer linked to H2 evolution possesses exceptional activity that merely requires a cell voltage of 1.45 V to deliver 40 mA cm−2, exhibiting a high FE (97.53%) for formate production and surpassing the vast majority of previously reported precious metal electrocatalysts. Microscopic and electrochemical characterizations manifest that the CuNiP/CuOx‐VP composed of porous NiP nanosheets attached to aggregated CuOx particles featuring superaerophobic‐hydrophilic morphology enables increased active sites, favorable electronic redistribution, and thus boosted electrocatalytic performance. This study demonstrates an effective nanoarrays electrode for catalyst discovery, going from facile catalyst synthesis to structure‐activity relationship and subsequently developing more highly active electrocatalysts for energy‐saving coproduction of valuable chemicals.
High Self‐Supporting Chitosan‐Based Hydrogel Ink for In Situ 3D Printed Diabetic Wound Dressing
Authors: Li Shanshan , Xu Yidi , Zheng Lu , Fan Chaoran , Luo Fangji , Zou Yuqing , Li Xiaoyun , Zha Zhen‐Gang , Zhang Huan‐Tian , Wang Xiaoying 
Published: October 2024

AbstractCustomizable 3D‐printed biopolymer hydrogels, highly sought after for diabetic wound management, face challenges in clinical application due to weak physical crosslinking within their constituent inks. In this study, a novel chitosan‐based hydrogel ink with a dense yet reversible physical crosslinking network is subtly designed for the rapid in situ fabrication of personalized diabetic wound dressing. This robust network is established through multiple electrostatic and hydrogen bonding interactions between unique carboxymethyl chitosan and nanoclay, further reinforced by the introduction of amide bonds, which act as double hydrogen bond donors/acceptors. Benefiting from this network, the ink with low nanoclay content exhibits remarkable self‐supporting properties, enabling high‐fidelity, large‐scale, and complex 3D printability without additional processing, while substantially retaining its inherent rheological properties after autoclave sterilization and the incorporation of active components. Given these advantages, this multifunctional 3D printable hydrogel can be rapidly in situ constructed on diabetic wounds. Simultaneously, the 3D‐printed hydrogel demonstrates biodegradability, anti‐swelling, and appropriate mechanical properties, along with remarkable in vitro antibacterial and pro‐angiogenic capabilities, leading to effective diabetic wound healing in vivo. This work offers a new strategy for creating highly self‐supporting biopolymer inks and paves the way for developing advanced personalized wound dressings.
Passivation of Deep‐Level Defects through Chemical Environment Regulation for Efficient CZTSSe Solar Cells Based on Active Selenium Adsorption–Desorption Process
Authors: Xie Tianliang , Han Litao , Chu Liangli , Han Mingtao , Jian Yue , Chi JinJin , Zhong Xinyi , Liu Tong , Kou Dongxing , Zhou Wenhui , Zhou Zhengji , Yuan Shengjie , Meng Yuena , Qi Yafang , Wu Sixin 
Published: October 2024

AbstractInsufficient selenization and uneven distribution of elements caused by the poor diffusion and reaction activity of selenium clusters is one of the main issues limiting the efficiency of Cu2ZnSn(S,Se)4 (CZTSSe) solar cells. Here, this work designs a simple and feasible strategy to improve the activity of selenium (Se) by implementing high‐temperature treatment on graphite boxes loaded with Se pellets. The rapid adsorption/desorption characteristics of graphite on active gaseous small‐molecule selenium have successfully introduced hyperactive Se4, Se3, and Se2 into the selenization process. The results indicate that the adsorbed non‐toxic gaseous active Se3 and Se4 can quickly and uniformly diffuse into the precursor film at low temperatures, thereby inducing nucleation and grain growth at both surface and back interface simultaneously, which inhibits the upward migration and aggregation of cations, especially Cu, and promotes the homogenization of elements. The overall relatively Cu‐poor chemical environment suppresses the formation of CuZn defects and [2CuZn+SnZn] defect clusters, and also promotes the generation of favorable VCu. The band tail states and non‐radiative recombination are then optimized. Finally, the CZTSSe solar cells achieve a power conversion efficiency (PCE) of 14.5%, with VOC/VOCSQ of 67% being one of the highest in the literature.
Physicochemical Properties of Water in Contact with Nanobubbles Generated by CO2‐Hydrate Dissociation: An Investigation from Experiment and Molecular‐Dynamics Simulation
Authors: Naeiji Parisa , Pan Mengdi , English Niall J. 
Published: October 2024

AbstractThe study investigates CO2‐nanobubbles (NBs) generated from gas‐hydrate dissociation, exploring their impact on the physicochemical properties of liquid water. Raman spectroscopy evidenced a slight increase in the Raman‐band intensity, suggesting enhanced total hydration‐layer water‐dipole moment and polarity without affecting water molecule structuring. Furthermore, an overall decreasing trend for the zeta potential of NB solution can be observed due to the strong electron affinity on the surface of CO2 bulk NBs, probably caused by a negative charge accumulation. These findings are in good qualitative accord with molecular‐dynamics (MD) simulation results, wherein water can induce a small dipole moment of about 0.16 D for CO2 NBs, thereby increasing the polarity of the system. Due to the interaction between water molecules, the Coulombic or electrostatic forces increase in the presence of NBs compared to pure water, which can reflect the increase in the dipole moment of water molecules in the presence of NBs. The presence of NBs strengthens the local hydrogen‐bond network, leading to higher‐frequency vibrations. Additionally, NBs amplify the intrinsic electric field of the aqueous solution, causing the gas‐water interface to exhibit negatively charged characteristics, dependent on NB size. Molecular simulations agree qualitatively with experiments, emphasizing their utility in studying NB evolution in water.
Ion‐Transport Kinetics and Interface Stability Augmentation of Zinc Anodes Based on Fluorinated Covalent Organic Framework Thin Films
Authors: Lei Da , Shang Wenzhe , Cheng Lyuyang , Poonam  , Kaiser Waldemar , Banerjee Pritam , Tu Suo , Henrotte Olivier , Zhang Jinsheng , Gagliardi Alessio , Jinschek Joerg , Cortés Emiliano , Müller‐Buschbaum Peter , Bandarenka Aliaksandr S. , Hussain Mian Zahid , Fischer Roland A. 
Published: October 2024

AbstractZinc (Zn) emerges as an ideal anode for aqueous‐based energy storage devices because of its safety, non‐toxicity, and cost‐effectiveness. However, the reversibility of zinc anodes is constrained by unchecked dendrite proliferation and parasitic side reactions. To minimize these adverse effects, a highly oriented, crystalline 2D porous fluorinated covalent organic framework (denoted as TpBD‐2F) thin film is in situ synthesized on the Zn anode as a protective layer. The zincophilic and hydrophobic TpBD‐2F provides numerous 1D fluorinated nanochannels, which facilitate the hopping/transfer of Zn2+ and repel H2O infiltration, thus regulating Zn2+ flux and inhibiting interfacial corrosion. The resulting TpBD‐2F protective film enabled stable plating/stripping in symmetric cells for over 1200 h at 2 mA cm−2. Furthermore, assembled full cells (Zn‐ion capacitors) deliver an ultra‐long cycling life of over 100 000 cycles at a current density of 5 A g−1, outperforming nearly all reported porous crystalline materials.
Novel Ag(I)‐based 1,2,4‐Oxadiazole Complexes: Synthesis, X‐Ray Crystal Structure, and Biological Evaluation as Anticancer Candidates
Authors: Ayoup Mohammed Salah , Alashhab Rabia E. , Soliman Saied M. , Abdel‐Hamid Hamida , Cordes David B. , McKay Aidan P. , Ghareeb Doaa A. , Masoud Aliaa , Kassab Asmaa E. , Abd Al Moaty Mohamed N. 
Published: October 2024

ABSTRACTThe 3,5‐diaryl‐1,2,4‐oxadiazole scaffolds 2 and 3 were synthesized and used as ligands to obtain three novel Ag(I) complexes 4–6. The structure of the Ag(I) complexes 4–6 has been confirmed by single crystal X‐ray diffraction. Complex 4 has the dinuclear formula [Ag(2)(NO3)]2. 5 and 6 are monomeric complexes having the formula [Ag(3)2(NO3)] and [Ag(3)2]ClO4, respectively. In vitro, trypsin, ALDH2, and iNOS inhibition activities were assessed for the free ligands and their Ag(I) complexes. Interestingly, Ag(I) complexes 4–6 revealed more prominent trypsin inhibitory activity than the ligands 2 and 3. The oxadiazole derivative 3 and its Ag(I) complex (6) showed significant ALDH2 inhibition (45% and 55%, respectively). Complex 6 (IC50 = 35.61 μM) surpassed its 1,2,4‐oxadiazole ligand 3 (IC50 = 88 μM) and evidenced the most prominent ALDH2 inhibitory activity. The oxadiazole derivative 3 and its corresponding Ag(I) complexes 5 and 6 showed significant iNOS inhibition (77.77%, 84.12%, and 84.15%, respectively). With IC50 values of 18.13, 18.15, and 13.96 μM, respectively, complex 6 is the most potent against iNOS, surpassing the reference standard.
Teaching delay tolerance to a child with Smith‐Magenis syndrome in a classroom using a simplified approach
Authors: DeFreitas Mariah , Womack Tyler , Choy Tricia , Ricciardi Joseph N. 
Published: October 2024

AbstractDelay tolerance training is used to teach children to accept delayed access to a requested item or event without exhibiting challenging behaviors. It is used during schedule thinning following acquisition of a functional communication response (FCR) or trained on its own in a skills‐based treatment package. Typically, delay tolerance training occurs in a clinic or hospital, and rarely in a school classroom. Most often delay tolerance training has been used with children with autism spectrum disorder (ASD). This study integrated findings from previous research on delay tolerance training to evaluate training in a classroom, with a child with Smith‐Magenis syndrome, using a simplified protocol. The training resulted in acquisition of delay tolerance for 5 min from a baseline of 32 s (average). The participant's teachers were then trained to use similar strategies throughout the school day and quickly acquired and applied the procedure with reported benefits.