bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winds induce CO2 exchange with the atmosphere and vadose zone transport in a karstic ecosystem
Authors: Sánchez‐Cañete Enrique P. , Oyonarte Cecilio , Serrano‐Ortiz Penélope , Curiel Yuste Jorge , Pérez‐Priego Oscar , Domingo Francisco , Kowalski Andrew S. 
Published: July 2016

AbstractResearch on the subterranean CO2 dynamics has focused individually on either surface soils or bedrock cavities, neglecting the interaction of both systems as a whole. In this regard, the vadose zone contains CO2‐enriched air (ca. 5% by volume) in the first meters, and its exchange with the atmosphere can represent from 10 to 90% of total ecosystem CO2 emissions. Despite its importance, to date still lacking are reliable and robust databases of vadose zone CO2 contents that would improve knowledge of seasonal‐annual aboveground‐belowground CO2 balances. Here we study 2.5 years of vadose zone CO2 dynamics in a semiarid ecosystem. The experimental design includes an integrative approach to continuously measure CO2 in vertical and horizontal soil profiles, following gradients from surface to deep horizons and from areas of net biological CO2 production (under plants) to areas of lowest CO2 production (bare soil), as well as a bedrock borehole representing karst cavities and ecosystem‐scale exchanges. We found that CO2 followed similar seasonal patterns for the different layers, with the maximum seasonal values of CO2 delayed with depth (deeper more delayed). However, the behavior of CO2 transport differed markedly among layers. Advective transport driven by wind induced CO2 emission both in surface soil and bedrock, but with negligible effect on subsurface soil, which appears to act as a buffer impeding rapid CO2 exchanges. Our study provides the first evidence of enrichment of CO2 under plant, hypothesizing that CO2‐rich air could come from root zone or by transport from deepest layers through cracks and fissures.
Tap water isotope ratios reflect urban water system structure and dynamics across a semiarid metropolitan area
Authors: Jameel Yusuf , Brewer Simon , Good Stephen P. , Tipple Brett J. , Ehleringer James R. , Bowen Gabriel J. 
Published: July 2016

AbstractWater extraction for anthropogenic use has become a major flux in the hydrological cycle. With increasing demand for water and challenges supplying it in the face of climate change, there is a pressing need to better understand connections between human populations, climate, water extraction, water use, and its impacts. To understand these connections, we collected and analyzed stable isotopic ratios of more than 800 urban tap water samples in a series of semiannual water surveys (spring and fall, 2013–2015) across the Salt Lake Valley (SLV) of northern Utah. Consistent with previous work, we found that mean tap water had a lower 2H and 18O concentration than local precipitation, highlighting the importance of nearby montane winter precipitation as source water for the region. However, we observed strong and structured spatiotemporal variation in tap water isotopic compositions across the region which we attribute to complex distribution systems, varying water management practices and multiple sources used across the valley. Water from different sources was not used uniformly throughout the area and we identified significant correlation between water source and demographic parameters including population and income. Isotopic mass balance indicated significant interannual and intra‐annual variability in water losses within the distribution network due to evaporation from surface water resources supplying the SLV. Our results demonstrate the effectiveness of isotopes as an indicator of water management strategies and climate impacts within regional urban water systems, with potential utility for monitoring, regulation, forensic, and a range of water resource research.
Synthesis, characterization and in vitro antimicrobial and anti‐breast cancer activity studies of metal complexes of novel pentadentate azo dye ligand
Authors: Mahmoud Walaa H. , Sayed Fatma N. , Mohamed Gehad G. 
Published: July 2016

A new azo dye with N3O2 donor set of atoms has been synthesized via coupling reaction of 2,6‐diaminopyridine with p‐methoxybenzaldehyde. The molecular and electronic structure of the azo dye ligand (L) was optimized theoretically and the quantum chemical parameters were calculated. Molecular docking was used to predict the binding between L and the receptors of breast cancer mutant 3hb5‐oxidoreductase, crystal structure of Escherichia coli (3 T88) and crystal structure of Staphylococcus aureus (3q8u). The newly synthesized L was used for complex formation with Cr(III), Mn(II), Fe(III), Co.(II), Ni(II), Cu(II), Zn(II) and Cd(II) ions. The nature of bonding and the stoichiometry of L and its mononuclear complexes were deduced from elemental analyses, spectroscopic, magnetic susceptibility, molar conductance, electron spin resonance and conductivity measurements, thermogravimetric analyses and powder X‐ray diffraction. Elemental analysis data show that the complexes have composition of ML type with an octahedral geometry for all the complexes. The activation thermodynamic parameters were calculated. The prepared azo dye and its metal complexes were tested against various Gram‐positive and Gram‐negative bacteria and a fungus. Most complexes exhibit antibacterial and antifungal activities against these organisms. Anticancer evaluation studies against standard breast cancer cell line were performed using various concentrations. The activity index was calculated. Copyright © 2016 John Wiley & Sons, Ltd.
The Synthesis of trans‐Flavan‐3‐ol Gallates by Regioselective Oxidative Etherification and Their Cytotoxicity Mediated by 67 LR
Authors: Shiraishi Nana , Kumazoe Motofumi , Fuse Shinichiro , Tachibana Hirofumi , Tanaka Hiroshi 
Published: July 2016

AbstractWe report on a chiral pool approach for the synthesis of trans‐flavan‐3‐ol gallates from epichlorohydrin. The trans‐flavan‐3‐ol gallates were prepared by the cycloetherification of the phenol at the C2 benzylic position of 2‐acylozyl‐1,3‐diarylpropane during regioselective C−H oxidation. The 1,3‐diarylpropanes were prepared starting from epichlorohydrin by epoxide opening with A and B ring precursors, followed by acylation of the resultant alcohol with galloyl chloride. The availability of both the enantiomers of epichlorohydrin allowed the preparation of the corresponding enantiomer using the same procedure. The cytotoxicity of the compounds against U266 cells was tested, in which 5‐deoxy‐7,3′‐O‐dimethyl gallocatechin gallate exhibited cytotoxicity that was more than ten times stronger than natural (−)‐EGCG. In addition, the absolute configuration of the derivatives did not critically affect the biological activity.
ChemInform Abstract: Broensted Acid Catalyzed Functionalization of Aromatic Alcohols Through Nucleophilic Substitution of Hydroxyl Group.
Authors: Mishra Abhishek Kumar , Biswas Srijit 
Published: July 2016

AbstractA simple direct nucleophilic substitution of OH‐groups in phenols, naphthols and 6‐hydroxyquinoline with O‐, S‐, N‐, and C‐nucleophiles is achieved with TosOH·H2O as catalyst.
ChemInform Abstract: Synthesis of Polyfunctionalized Benzophenones via the Reaction of 3‐Formylchromones with Tertiary Push—Pull Enamines.
Authors: Barkov Alexey Yu. , Korotaev Vladislav Yu. , Kutyashev Igor B. , Sosnovskikh Vyacheslav Ya. 
Published: July 2016

AbstractReaction of pyran (I) with tertiary enamines proceeds in refluxing acetonitrile without any catalyst to give polyfunctionalized benzophenone derivatives as a result of a [3 + 3] annulation.
ChemInform Abstract: A Convenient One‐Pot Synthesis of Triazolopyridine and Related Heterocycle Fused‐Triazole Analogues Through Copper Catalyzed Oxidative Cyclization Strategy.
Authors: Srinivasan R. , Sembian Ruso J. , Nagarajan N. S. , Senthil Kumaran R. , Manickam G. 
Published: July 2016

AbstractThe synthesis of the title compounds from various aldehydes and heteroarylhydrazines involves the oxidative cyclization of in situ generated hydrazones under mild reaction conditions as key step.
ChemInform Abstract: Ring‐Opening of Carbamate‐Protected Aziridines and Azetidines in Liquid Sulfur Dioxide.
Authors: Luginina Jevgenija , Uzulena Jevgenija , Posevins Daniels , Turks Maris 
Published: July 2016

AbstractThe ring‐opening of N‐carbamate‐protected aziridines and azetidines with thio nucleophiles and halides in liquid sulfur dioxide as highly polar solvent is investigated.
ChemInform Abstract: Exceptional Activity of Gallium(III) Chloride and Chlorogallate(III) Ionic Liquids for Baeyer—Villiger Oxidation.
Authors: Markiton Magdalena , Chrobok Anna , Matuszek Karolina , Seddon Kenneth R. , Swadzba‐Kwasny Malgorzata 
Published: July 2016

AbstractThe Baeyer—Villinger oxidation of cyclic ketones with H2O2 as oxidizing agent using a range of metal chlorides in different solvents or neat chlorogallate(III) ionic liquids is investigated.
ChemInform Abstract: Chiral N‐Phosphonyl Imines for an Aza‐Morita—Baylis—Hillman Reaction via Group‐Assisted Purification (GAP) Chemistry.
Authors: Yang Bing , Shen Minxing , Ji Xiaozhou , Xu Ziyan , Sun Hao , Jiang Bo , Li Guigen 
Published: July 2016

AbstractUtilization of group‐assisted purification chemistry provides pure products by washing the crude materials with hexane/ethyl acetate co‐solvents.
ChemInform Abstract: Dimethyl Malonate/LHMDS System as a New Protocol for Generating Methyl Formate Anion (‐COOMe) in the Condensed‐Phase.
Authors: Di Bussolo Valeria , Princiotto Salvatore , Martinelli Elisa , Bordoni Vittorio , Crotti Paolo 
Published: July 2016

AbstractTreatment of dimethyl malonate with LiN(Tms)2 generates the expected lithium enolate and methyl formate anion.
ChemInform Abstract: Mild and Site‐Selective Allylation of Enol Carbamates with Allylic Carbonates under Rhodium Catalysis
Authors: Sharma Satyasheel , Han Sang Hoon , Oh Yongguk , Mishra Neeraj Kumar , Han Sangil , Kwak Jong Hwan , Lee Seok‐Yong , Jung Young Hoon , Kim In Su 
Published: July 2016

Abstractgives various allylic alcohols and terminal allylated products
ChemInform Abstract: Amide α,β‐Dehydrogenation Using Allyl‐Palladium Catalysis and a Hindered Monodentate Anilide.
Authors: Chen Yifeng , Turlik Aneta , Newhouse Timothy R. 
Published: July 2016

AbstractAmides are dehydrogenated using a novel and recyclable base, lithium N‐cyclohexyl anilide.
ChemInform Abstract: Copper Porphyrin‐Catalyzed Aerobic Oxidative Coupling of Terminal Alkynes with High TON.
Authors: Sheng Wen‐Bing , Chen Tie‐Qiao , Zhang Ming‐Zhong , Tian Mi , Jiang Guo‐Fang , Guo Can‐Cheng 
Published: July 2016

AbstractThe title coupling reaction provides access to various functionalized 1,3‐diynes under mild conditions and in a short reaction time.
ChemInform Abstract: α‐Carbamoylsulfides as N‐Carbamoylimine Precursors in the Visible Light Photoredox‐Catalyzed Synthesis of α,α‐Disubstituted Amines.
Authors: Lebee Clement , Languet Morgan , Allain Clemence , Masson Geraldine 
Published: July 2016

AbstractThe procedure allows the preparation of a broad spectrum of the desired target compounds.
ChemInform Abstract: Pd/C as an Efficient and Reusable Catalyst for the Selective N‐Alkylation of Amines with Alcohols.
Authors: Liu Xiang , Hermange Philippe , Ruiz Jaime , Astruc Didier 
Published: July 2016

AbstractThe title reaction features sustainable, simple, and economic process, but bromophenyl group is not tolerated because of the unfavorable competition with dehalogenation reaction.
ChemInform Abstract: Enantioconvergent Fukuyama Cross‐Coupling of Racemic Benzylic Organozinc Reagents.
Authors: Oost Rik , Misale Antonio , Maulide Nuno 
Published: July 2016

AbstractA variety of enantioenriched α‐disubstituted ketones are prepared by the first general catalytic asymmetric method for the cross‐coupling of thioesters by deracemization of racemic benzylic organozinc reagents under mild reaction conditions.
ChemInform Abstract: Visible‐Light‐Mediated Aromatic Substitution Reactions of Cyanoarenes with 4‐Alkyl‐1,4‐dihydropyridines Through Double Carbon—Carbon Bond Cleavage.
Authors: Nakajima Kazunari , Nojima Sunao , Sakata Ken , Nishibayashi Yoshiaki 
Published: July 2016

AbstractThe title reaction affords alkyl‐substituted arenes in good to high yields.
ChemInform Abstract: One‐Pot Synthesis of Acyloxy Carbonyl Compounds from Ketones Using a Pybox—Copper(II) Catalyst.
Authors: Jia Wei‐Guo , Zhang Hui , Li Dan‐Dan , Yan Li‐Qin 
Published: July 2016

AbstractA series of α‐acyloxy ketone products are prepared for the first time by an efficient, green one‐pot method from ketones under mild reaction conditions.
ChemInform Abstract: Direct α‐Acyloxylation of Organic Sulfides with the Hypervalent (Diacyloxyiodo)benzene/Tetra‐n‐butylammonium Bromide (TBAB) Reagent Combination.
Authors: Zhu Dan , Chang Denghu , Gan Shaoyan , Shi Lei 
Published: July 2016

Abstractα‐Acyloxy sulfides are directly synthesized under metal‐free conditions starting from a broad range of readily available alkyl sulfides.
ChemInform Abstract: Molecular Iodine‐Mediated Difunctionalization of Alkenes with Nitriles and Thiols Leading to β‐Acetamido Sulfides.
Authors: Cui Huanhuan , Liu Xiaoxia , Wei Wei , Yang Daoshan , He Chenglong , Zhang Tiantian , Wang Hua 
Published: July 2016

AbstractA three‐component reaction of olefins, thiols, and aliphatic nitriles with molecular iodine as catalyst is presented to give β‐acylamidosulfides.
ChemInform Abstract: Cationic Pd(II)‐Catalyzed C—H Activation/Cross‐Coupling Reactions at Room Temperature: Synthetic and Mechanistic Studies.
Authors: Nishikata Takashi , Abela Alexander R , Huang Shenlin , Lipshutz Bruce H 
Published: July 2016

AbstractThe cationic palladium complex enables C—H activation of arylureas with arylboronic acids and acrylates in Suzuki—Miyaura and Fujiwara—Moritani couplings, resp., under milder reaction conditions than those previously reported.
ChemInform Abstract: α‐Arylation of Ketimines with Aryl Sulfides at a Low Palladium Catalyst Loading.
Authors: Gao Ke , Yorimitsu Hideki , Osuka Atsuhiro 
Published: July 2016

AbstractThe arylation reactions are efficient at low loadings of the palladium‐NHC complex (down to 0.5 mol%).
ChemInform Abstract: Open‐Air Oxidative Mizoroki—Heck Reaction of Arylsulfonyl Hydrazides with Alkenes.
Authors: Yuen On Ying , So Chau Ming , Kwong Fuk Yee 
Published: July 2016

AbstractThe novel oxidative Mizoroki—Heck reaction of arylsulfonyl hydrazides with alkenes proceeds under open‐air using an air‐ and moisture‐stable pyridine ligand and palladium(II) catalyst.
ChemInform Abstract: Copper‐Catalyzed N‐Arylation of Tautomerizable Heterocycles with Boronic Acids and its Application to Synthesis of Oxygenated Carbazoles.
Authors: Kumar Karampoori Anil , Kannaboina Prakash , Jaladanki Chaitanya K. , Bharatam Prasad V. , Das Parthasarathi 
Published: July 2016

AbstractThe selective N‐arylation of heterocycles with a series of arylboronic acids under base free conditions at ambient atmosphere is presented.
ChemInform Abstract: Enantiodivergent Brucine Diol‐Catalyzed 1,3‐Dipolar Cycloaddition of Azomethine Ylides with α,β‐Unsaturated Ketones.
Authors: Li Jian‐Yuan , Kim Hun Young , Oh Kyungsoo 
Published: July 2016

AbstractEnantiodivergent catalyst systems including brucine diol as chiral component are developed to allow the 1,3‐dipolar cycloaddition of azomethine ylides with chalcone derivatives to give tetrasubstituted pyrrolidines highly stereoselectively.
ChemInform Abstract: Br2‐Catalyzed Regioselective Dehydrative Coupling of Indoles with Acyloins: Direct Synthesis of α‐(3‐Indolyl) Ketones.
Authors: Liang Deqiang , Li Xiangguang , Li Yanni , Yang Yungang , Gao Shulin , Cheng Ping 
Published: July 2016

AbstractIn this reaction Br2 serves as a Lewis acid.
ChemInform Abstract: Synthesis of 2,1‐Benzisoxazole‐3(1H)‐ones by Base‐Mediated Photochemical N—O Bond‐Forming Cyclization of 2‐Azidobenzoic Acids.
Authors: Dzhons Daria Yu. , Budruev Andrei V. 
Published: July 2016

AbstractPhotocyclization of o‐azidocarboxylic acids of type (I) offers a convenient access to 2,1‐benzisoxazolones.
ChemInform Abstract: An Environment‐Friendly Synthesis of 2,3‐Disubstituted‐2‐iminothiazoline‐4‐ones
Authors: Meng Ge , Zheng Meilin , Dong Mengshu , Wang Mei , Zheng Aqun , Guo Zengjun 
Published: July 2016

Abstract[starting from aromatic or aliphatic substituted iminothiazolines by an improved method including an auto‐catalyzed reaction.]
ChemInform Abstract: Influence of A1,3 Strain on the Stereochemical Outcome of Acid‐Mediated Amido Cyclization in the Synthesis of 2‐(4‐Methoxyphenyl)‐3,4‐(dihydroxy)piperidines.
Authors: Ramakrishna Katakam , Jagadeesh Yerri , Ramakrishna K. V. S. , Rao Joshi Laxmikanth , Rao Batchu Venkateswara 
Published: July 2016

AbstractA straightforward synthesis of the title compounds is reported based on an acid‐mediated amido cyclization reaction as the key step.
ChemInform Abstract: Stereoselectivity of 6‐Exo Cyclization of α‐Carbamoyl Radicals.
Authors: Song Liyan , Fang Xinqiang , Wang Zijia , Liu Kun , Li Chaozhong 
Published: July 2016

AbstractThe BEt3/O2‐initiated iodine‐atom‐transfer radical cyclization reactions of substituted N‐(but‐3‐en‐1‐yl)‐N‐(tert‐butyl)‐2‐iodoalkanamides furnishes predominantly 3,4‐cis, 4,5‐trans, or 4,6‐trans substituted δ‐lactams.
ChemInform Abstract: Palladium‐Catalyzed Ligand‐Promoted Site‐Selective Cyanomethylation of Unactivated C(sp3)—H Bonds with Acetonitrile.
Authors: Liu Yongbing , Yang Ke , Ge Haibo 
Published: July 2016

AbstractThe title cyanomethylation of aliphatic amides is assisted by a bidentate directing group N‐quinoline.
ChemInform Abstract: Organocatalytically Generated Donor—Acceptor Cyclopropanes in Domino Reactions. One‐Step Enantioselective Synthesis of Pyrrolo[1,2‐a]quinolines.
Authors: Sanchez‐Diez Eduardo , Vesga Diana L. , Reyes Efraim , Uria Uxue , Carrillo Luisa , Vicario Jose L. 
Published: July 2016

Abstracto‐Aminobenzaldehydes react with cyclopropaneacetaldehydes under conditions A) in a one‐pot domino process to produce dihydroquinolines with good to excellent e.e.
ChemInform Abstract: An Unexpected Pyrimidine Ring Transformations in the Reaction of 4‐Aryl‐5‐nitro‐6‐bromomethylpyrimidin‐2(1H)‐ones with Anilines.
Authors: Remennikov Grigoriy Ya , Gavryushin Andrey , Polborn Kurt 
Published: July 2016

AbstractThe reaction of dihydropyrimidinone derivatives with anilines depending on the conditions leads to products of a ring contraction of the pyrimidinone ring into an imidazolone, as well as to the formation of dihydroisoxazolopyrimidinone derivatives, and in some cases to aminopyrimidinone.
ChemInform Abstract: Enantioselective Synthesis of Spirobarbiturate‐Cyclohexenes Through Phosphine‐Catalyzed Asymmetric [4 + 2] Annulation of Barbiturate‐Derived Alkenes with Allenoates.
Authors: Guo Hongchao , et al.  
Published: July 2016

AbstractThe method renders possible the access to various pharmaceutically important title compounds with complete diastereoselectivity and high enantioselectivity.
ChemInform Abstract: The Facile Synthesis of 1‐Benzoazepine Derivatives via Gold‐Catalyzed Regioselective Cycloisomerization Reactions of N‐(o‐Alkynylaryl)‐N‐vinyl Sulfonamides.
Authors: Undeela Sridhar , Ravikumar Gurram , Nanubolu Jagadeesh Babu , Singarapu Kiran Kumar , Menon Rajeev S. 
Published: July 2016

AbstractThe title compounds are prepared by 7‐endo‐dig‐selective cycloisomerization of (alkynylphenyl)vinylsulfonamides in excellent yields.
ChemInform Abstract: Copper‐Catalyzed Cross‐Coupling Reactions of Epoxides with gem‐Diborylmethane: Access to γ‐Hydroxyl Boronic Esters.
Authors: Ebrahim‐Alkhalil Ahmed , Zhang Zhen‐Qi , Gong Tian‐Jun , Su Wei , Lu Xiao‐Yu , Xiao Bin , Fu Yao 
Published: July 2016

AbstractThe method can also be extended to N‐sulfonyl aziridine.
ChemInform Abstract: Synthesis of (.+‐.)‐Serralongamine A and the Revised Structure of Huperzine N.
Authors: Saborit Gisela V. , Bosch Caroline , Parella Teodor , Bradshaw Ben , Bonjoch Josep 
Published: July 2016

AbstractPhlegmarine alkaloid serralongamine A (I) is prepared for the first time and transformed into huperzine N (II) allowing for a revision of it′s putative structure.
ChemInform Abstract: Total Synthesis and Structural Reassignment of Aspergillomarasmine A.
Authors: Liao Daohong , Yang Shaoqiang , Wang Jianyu , Zhang Jian , Hong Benke , Wu Fan , Lei Xiaoguang 
Published: July 2016

AbstractSynthesis of compounds (I) and (II) identifies (I) as Aspergillomarasmine A instead of the previously proposed structure (II).
ChemInform Abstract: Applications of Hierarchically Structured Porous Materials from Energy Storage and Conversion, Catalysis, Photocatalysis, Adsorption, Separation, and Sensing to Biomedicine
Authors: Sun Ming‐Hui , Huang Shao‐Zhuan , Chen Li‐Hua , Li Yu , Yang Xiao‐Yu , Yuan Zhong‐Yong , Su Bao‐Lian 
Published: July 2016

AbstractReview: 584 refs.
Discovery of HIV Type 1 Aspartic Protease Hit Compounds through Combined Computational Approaches
Authors: Xanthopoulos Dimitrios , Kritsi Eftichia , Supuran Claudiu T. , Papadopoulos Manthos G. , Leonis Georgios , Zoumpoulakis Panagiotis 
Published: July 2016

AbstractA combination of computational techniques and inhibition assay experiments was employed to identify hit compounds from commercial libraries with enhanced inhibitory potency against HIV type 1 aspartic protease (HIV PR). Extensive virtual screening with the aid of reliable pharmacophore models yielded five candidate protease inhibitors. Subsequent molecular dynamics and molecular mechanics Poisson–Boltzmann surface area free‐energy calculations for the five ligand–HIV PR complexes suggested a high stability of the systems through hydrogen‐bond interactions between the ligands and the protease's flaps (Ile50/50′), as well as interactions with residues of the active site (Asp25/25′/29/29′/30/30′). Binding‐energy calculations for the three most promising compounds yielded values between −5 and −10 kcal mol−1and suggested that van der Waals interactions contribute most favorably to the total energy. The predicted binding‐energy values were verified by in vitro inhibition assays, which showed promising results in the high nanomolar range. These results provide structural considerations that may guide further hit‐to‐lead optimization toward improved anti‐HIV drugs.
Accuracy of the Magnetic Field Gradient Waveform Monitor Technique and Consequent Accuracy of Pre‐Equalized Gradient Waveform
Authors: Goora Frédéric G. , Balcom Bruce J. 
Published: July 2016

AbstractThe magnetic field gradient waveform monitor (MFGM) technique permits characterization of the temporal evolution of magnetic field gradients in magnetic resonance (MR) instruments (MRIs). Knowledge of the gradient waveform performance permits the development of further techniques, such as gradient waveform pre‐equalization, that correct and optimize gradient waveform distortions due to eddy currents induced during the application of switched magnetic fields and other system limitations. The accuracy of the MFGM technique is important since the overall uncertainty of the gradient waveform measurement will propagate into an uncertainty in corrected gradient waveforms impacting the precision of the resulting MR/MRI measurements. The accuracy of MFGM is investigated through a treatment of the noise present in a MRI. A noisy receiver model provides the basis for characterization of the noise and permits examination of the overall impact of noise on the phase accumulated in a pure‐phase encoded MR signal. Ultimately, a relationship between the signal‐to‐noise ratio of a measurement and the corresponding MFGM uncertainty is developed. The theoretical development is supported through simulation in conjunction with experimental results. The propagation of uncertainties to gradient waveform pre‐equalization is also discussed.