bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-Hospital Neurologic Complications in Adult Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation: Results From the Extracorporeal Life Support Organization Registry
Authors: Lorusso Roberto , Barili Fabio , Mauro Michele Di , Gelsomino Sandro , Parise Orlando , Rycus Peter T. , Maessen Jos , Mueller Thomas , Muellenbach Raf , Belohlavek Jan , Peek Giles , Combes Alain , Frenckner Bjorn , Pesenti Antonio , Thiagarajan Ravi R. 
Published: June 2016

Objectives:
To elucidate the epidemiology, complication profiles, hospital outcome, and predisposing factors of CNS complications occurring during venoarterial extracorporeal membrane oxygenation in adults.

Design:
Retrospective analysis of the Extracorporeal Life Support Organization registry.

Setting:
Data reported to Extracorporeal Life Support Organization by 230 extracorporeal membrane oxygenation centers from 1992 to 2013.

Patients:
Patients more than 16 years old supported with a single-run of venoarterial extracorporeal membrane oxygenation.

Interventions:
None.

Measurements and Main Results:
We examined 4,522 adult patients supported with venoarterial extracorporeal membrane oxygenation and included in the Extracorporeal Life Support Organization registry. Venoarterial extracorporeal membrane oxygenation was used for cardiac dysfunction in 3,005 patients (66.5%), cardiopulmonary resuscitation in 877 patients (19.4%), and respiratory failure in 640 patients (14.1%), respectively. Multivariate logistic regression was performed to identify factors independently associated with CNS injury. Neurologic complications occurred in 682 patients (15.1%), and included brain death in 358 patients (7.9%), cerebral infarction in 161 patients (3.6%), seizures in 83 patients (1.8%), and cerebral hemorrhage in 80 patients (1.8%). Multiple CNS complications in the same patient occurred in 70 cases. Hospital mortality in patients with CNS complications was 89%, compared with 57% in patients without (p < 0.001). In a multivariable model, age, pre-extracorporeal membrane oxygenation cardiac arrest, the use of inotropes on extracorporeal membrane oxygenation, and post-extracorporeal membrane oxygenation hypoglycemia were shown to be associated with CNS complications.

Conclusions:
Neurologic complications in adult patients on venoarterial extracorporeal membrane oxygenation support are common and associated with poor survival. Further research should focus on better understanding and management of brain/extracorporeal membrane oxygenation interaction to avoid such catastrophic complications.
Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis
Authors: Cardoso Josue S. , Riley Joseph L. , Glover Toni , Sibille Kimberly T. , Bartley Emily J. , Goodin Burel R. , Bulls Hailey W. , Herbert Matthew , Addison Adriana S. , Staud Roland , Redden David T. , Bradley Laurence A. , Fillingim Roger B. , Cruz-Almeida Yenisel 
Published: June 2016

Abstract
Pain among individuals with knee osteoarthritis (OA) is associated with significant disability in older adults, and recent evidence demonstrates enhanced experimental pain sensitivity. Although previous research showed considerable heterogeneity in the OA clinical pain presentation, less is known regarding the variability in responses to experimental pain. The present study included individuals with knee OA (n = 292) who participated in the Understanding Pain and Limitations in Osteoarthritic Disease study and completed demographic and psychological questionnaires followed by a multimodal quantitative sensory testing (QST) session. Quantitative sensory testing measures were subjected to variable reduction procedures to derive pain sensitivity index scores, which in turn were entered into a cluster analysis. Five clusters were significantly different across all pain sensitivity index variables (P < 0.001) and were characterized by: (1) low pain sensitivity to pressure pain (N = 39); (2) average pain sensitivity across most modalities (N = 88); (3) high temporal summation of punctate pain (N = 38); (4) high cold pain sensitivity (N = 80); and (5) high sensitivity to heat pain and temporal summation of heat pain (N = 41). Clusters differed significantly by race, gender, somatic reactivity, and catastrophizing (P < 0.05). Our findings support the notion that there are distinct subgroups or phenotypes based on experimental pain sensitivity in community-dwelling older adults with knee OA, expanding previous findings of similar cluster characterizations in healthy adults. Future research is needed to further understand the pathophysiological mechanisms underlying pain within these subgroups, which may be of added value in tailoring effective treatments for people with OA.
BMI history and risk of incident fatty liver: a population-based large-scale cohort study
Authors: Hashimoto Yoshitaka , Hamaguchi Masahide , Fukuda Takuya , Nakamura Naoto , Ohbora Akihiro , Kojima Takao , Fukui Michiaki 
Published: June 2016

Background and aims
Most physicians might consider that fatty liver would develop along with increasing body weight; however, an association between BMI history and incident fatty liver has not been clarified as yet.

Methods
We carried out a population-based cohort study that included 4427 healthy Japanese individuals who received yearly health-checkup programs over a decade. Fatty liver was diagnosed using ultrasonography.

Results
During the observational period, 38.7% (case/N=1002/2588) of men and 17.3% (319/1847) of women were diagnosed with fatty liver. Among these, only 18.9% (189 of 1002 participants) of men and 18.5% (59 of 319) of women developed fatty liver when they reached the lifetime maximum BMI. Adjusted odds ratio of the difference between lifetime maximum BMI and BMI at age 20 years (ΔBMImax−20 years) for incident fatty liver was 1.33 [95% confidence interval (CI) 1.28–1.39, P<0.001] in men or 1.40 (95% CI 1.33–1.49, P<0.001) in women. According to receiver operator characteristic (ROC) analysis, the optimal cut-off points of ΔBMImax−20 years for incident fatty liver were 4.82 kg/m2 [area under ROC curve 0.70 (95% CI 0.68–0.72), P<0.001] in men and 4.11 kg/m2 [area under ROC curve 0.76 (95% CI 0.73–0.79), P<0.001] in women.

Conclusion
The ΔBMImax−20 years was associated with an increased risk of incident fatty liver. In addition, more patients developed fatty liver not at the maximum point of BMI history, but after that. Therefore, it is useful to check ΔBMImax−20 years and to continue observing the individuals for detection of fatty liver.
The Effect of Concomitant Sirolimus and Propofol Therapy on Triglyceride Concentrations in Critically Ill Patients
Authors: Dube Kevin M. , Szumita Paul M. , Rocchio Megan A. , Lee Po-Shun , Anger Kevin E. 
Published: June 2016

Background:Sirolimus and propofol are both independently associated with the development of hypertriglyceridemia (HTG) during therapy. To date, there are no published reports describing synergistic or additive drug interaction resulting in HTG with concomitant use of these medications.Study Question:To identify the occurrence of HTG in patients receiving concomitant sirolimus and propofol infusion therapy.Methods:Adult patients receiving sirolimus and a continuous propofol infusion for at least 12 hours from January 2005 to August 2009 were retrospectively evaluated. Data included Acute Physiology and Chronic Health Evaluation II score, weight, length of propofol therapy, and baseline triglyceride (TG) concentrations. The major outcome was incidence of HTG (TGs ≥500 mg/dL). Minor outcomes included the change in TG concentration from therapy initiation and manifestations of propofol-related infusion syndrome (PRIS).Results:Sixteen patients were included in the analysis, with 8 (50%) of the patients developing HTG. The patients in this case series had the following mean values: Acute Physiology and Chronic Health Evaluation II score of 20.2 ± 5.3, weight of 76.3 ± 21.2 kg, and baseline TG concentrations of 181.3 ± 89.7 mg/dL. Indications for sirolimus therapy included hematopoietic stem-cell transplantation (n = 15) and heart transplantation (n = 1). Mean length of propofol infusion was 99.8 ± 88.5 hours. The mean TG concentration during infusion was 515.6 ± 468.1 mg/dL. Fourteen (87.5%) patients had an increase of ≥100 mg/dL, 12 (75%) patients had an increase of ≥200 mg/dL, and 6 (37.5%) patients had an increase of ≥300 mg/dL in TG concentrations during therapy. Eleven patients developed one manifestation of PRIS, excluding HTG, and one patient had more than 2 new onset PRIS manifestations during propofol therapy.Conclusions:Coadministration of propofol and sirolimus can potentially result in HTG, which may warrant more frequent monitoring. Further analysis is needed to examine the mechanism and clinical impact of this interaction.
Successful Corticosteroid Treatment of Refractory Spontaneous Vasoconstriction of Extracranial Internal Carotid and Coronary Arteries
Authors: Takeuchi Mariko , Saito Kozue , Kajimoto Katsufumi , Nagatsuka Kazuyuki 
Published: June 2016

Introduction:
Spontaneous vasoconstriction of the extracranial internal carotid artery (SVEICA) is a rare cause of cerebral infarction. Most patients with SVEICA suffer recurrent attacks of vasoconstriction. The standard treatment for this condition has not been established and its long-term prognosis is unclear.

Case Report:
A 25-year-old man with a history of refractory vasospasm angina presented with transient alternating hemiplegia in both the right and left side. Serial carotid ultrasonography examinations showed severe transient stenosis or occlusion of cervical internal carotid arteries on 1 or both sides, with and without neurological symptoms. This condition resolved completely within 1 day to 1 week. The patient did not present any other risk factors for atherosclerosis and was diagnosed with SVEICA. The treatment with calcium antagonists and nitrates did not prevent the attacks. Administration of a corticosteroid substantially reduced the vasospasm attacks.

Conclusions:
SVEICA is intractable and difficult to diagnose. It has been reported that SVEICA sometimes complicates coronary artery disease, as observed in this case. The present case demonstrated the effectiveness of corticosteroid treatment against this disease. Serial ultrasonography examinations helped us to diagnose and follow-up the vasospasm attacks.
Reversible Edema-Like Changes Along the Optic Tract Following Pipeline-Assisted Coiling of a Large Anterior Communicating Artery Aneurysm
Authors: La Pira Biagia , Brinjikji Waleed , Hunt Christopher , Chen John J. , Lanzino Giuseppe 
Published: June 2016

Abstract:
Aneurysmal volume expansion after endovascular treatment is caused by intra-aneurysmal thrombosis in the early postembolization period. Although postembolization mass effect on cranial nerves and other adjacent structures has been previously reported, we are unaware of reports involving the anterior visual pathway. A 66-year-old woman with a 2-week history of blurred vision without headache was found to have a large, unruptured anterior communicating artery aneurysm. One month after endovascular treatment of the aneurysm with coiling and flow diversion, the patient developed decreased vision in her right eye and a left homonymous hemianopia. Magnetic resonance imaging demonstrated compression of the right optic nerve, chiasm, and edema of the right optic tract. The patient was treated with a course of high dose corticosteroids, and over the course of several weeks, her vision improved and the optic tract edema resolved. We alert clinicians to this rare but potentially reversible visual complication of endovascular treatment of intracranial aneurysms.
The mitotic kinesin-14 KlpA contains a context-dependent directionality switch
Authors: Popchock Andrew R. , Tseng Kuo-Fu , Wang Pan , Karplus P. Andrew , Xiang Xin , Qiu Weihong 
Published: June 2016

AbstractKinesins are microtubule-based motor proteins that convert chemical energy from ATP hydrolysis into mechanical work for a variety of essential intracellular processes. Kinesin-14s (i.e. kinesins with a C-terminal motor domain) are commonly considered to be nonprocessive minus end-directed motors that mainly function for mitotic spindle assembly and maintenance. Here, we show that KlpA – a mitotic kinesin-14 motor from the filamentous fungusAspergillus nidulans– contains a context-dependent directionality switch. KlpA exhibits canonical minus end-directed motility inside microtubule bundles, but on individual microtubules it unexpectedly moves processively toward the plus ends. Removal of the N-terminal nonmotor microtubule-binding domain renders KlpA diffusive on individual microtubules but does not abolish its minus end-directed motility to collectively glide microtubules, suggesting that the nonmotor microtubule-binding domain likely acts as a switch for controlling the direction of KlpA motility. Collectively, these findings provide important insights into the mechanism and regulation of KlpA functions inside the mitotic spindle.
Whole Exome Sequencing in Neurogenetic Diagnostic Odysseys: An Argentinian Experience
Authors: Córdoba M , Rodriguez-Quiroga SA , Vega PA , Amartino H , Vázquez-Dusefante C , Medina N , González-Morón D , Kauffman MA 
Published: June 2016

ABSTRACTClinical variability is a hallmark of neurogenetic disorders. They involve widespread neurological entities such as neuropathies, ataxias, myopathies, mitochondrial encephalopathies, leukodystrophies, epilepsy and intellectual disabilities. Despite the use of considerable time and resources, the diagnostic yield in this field has been disappointingly low. This etiologic search has been called a “diagnostic odyssey” for many families. Whole exome sequencing (WES) has proved to be useful across a variety of genetic disorders, simplifying the odyssey of many patients and their families and leading to subsequent changes in clinical management in a proportion of them. Although a diagnostic yield of about 30% in neurogenetic disorders can be extrapolated from the results of large series that have included other medical conditions as well, there are not specific reports assessing its utility in a setting such as ours:a neurogeneticist ledacademic group serving in a low-income country. Herein, we report on a series of our first 40 consecutive cases that were selected for WES in a research-based neurogenetics laboratory. We demonstrated the clinical utility of WES in our patient cohort, obtaining a diagnostic yield of 40% (95% CI, 24.8%-55.2%), describing cases in which clinical management was altered, and suggesting the potential cost-effectiveness of WES as a single test by examining the number and types of tests that were performed prior to WES which added up to a median cost of $3537.6 ($2892 to $5084) for the diagnostic odysseys experienced by our cohort.
Translational contributions to tissue-specificity in rhythmic and constitutive gene expression
Authors: Castelo-Szekely Violeta , Arpat Alaaddin Bulak , Janich Peggy , Gatfield David 
Published: June 2016

AbstractBACKGROUNDThe daily gene expression oscillations that underlie mammalian circadian rhythms show striking tissue differences and involve post-transcriptional regulation. Both aspects remain poorly understood. We have used ribosome profiling to explore the contribution of translation efficiency to temporal gene expression in kidney, and contrasted our findings with liver data available from the same mice.RESULTSRhythmic translation of constantly abundant mRNAs affected largely non-overlapping transcript sets with distinct phase clustering in the two organs. Moreover, tissue differences in translation efficiency modulated the timing and amount of protein biosynthesis from rhythmic mRNAs, consistent with organ-specificity in clock output gene repertoires and rhythmicity parameters. Our comprehensive datasets provided insights into translational control beyond temporal regulation. Between tissues, many transcripts showed differences in translation efficiency, which were, however, of markedly smaller scale than mRNA abundance differences. Tissue-specific changes in translation efficiency were associated with specific transcript features and, intriguingly, globally counteracted and compensated transcript abundance variations, leading to higher similarity at the level of protein biosynthesis between both tissues.CONCLUSIONSWe show that tissue-specificity in rhythmic gene expression extends to the translatome and contributes to define the identities, the phases and the expression levels of rhythmic protein biosynthesis. Moreover, translational compensation of transcript abundance divergence leads to overall higher similarity at the level of protein production across organs. The unique resources provided through our study will serve to address fundamental questions of post-transcriptional control and differential gene expression in vivo.
Optimization of an antiStaphylococcusantibiotic produced by tropical soil dwellingStreptomyces parvulus
Authors: Velho-Pereira Sonashia , Kamat Nandkumar M 
Published: June 2016

AbstractAn antibiotic produced by strainStreptomyces parvulusshowing activity againstStaphylococcus citreuswas subjected to various optimization parameters for enhancing its production. Nutritional and physiological parameters produced byS. parvulusunder shaken flask conditions were determined. Optimization of these parameters led to 11% increase in antibiotic activity with a mean zone of inhibition of 42 mm.Highest antibiotic production was obtained at 250 rpm for 14 days with optimum temperature of 28°C and pH 7. Kuster#x2019;s modified medium containing glycerol 0.7% (v/v), casein 0.03% (w/v), NaCl 0% (w/v), phosphate 0.25% (w/v), KNO3 0.1% (w/v) and CaCO3 0.0015% (w/v) concentration was found ideal.
A descriptive marker gene approach to single-cell pseudotime inference
Authors: Campbell Kieran R , Yau Christopher 
Published: June 2016

AbstractPseudotime estimation from single-cell gene expression allows the recovery of temporal information from otherwise static profiles of individual cells. This pseudotemporal information can be used to characterise transient events in temporally evolving biological systems. Conventional algorithms typically emphasise an unsupervised transcriptome-wide approach and use retrospective analysis to evaluate the behaviour of individual genes. Here we introduce an orthogonal approach termed “Ouija” that learns pseudotimes from a small set of marker genes that might ordinarily be used to retrospectively confirm the accuracy of unsupervised pseudotime algorithms. Crucially, we model these genes in terms of switch-like or transient behaviour along the trajectory, allowing us to understand why the pseudotimes have been inferred and learn informative parameters about the behaviour of each gene. Since each gene is associated with a switch or peak time the genes are effectively ordered along with the cells, allowing each part of the trajectory to be understood in terms of the behaviour of certain genes. In the following we introduce our model and demonstrate that in many instances a small panel of marker genes can recover pseudotimes that are consistent with those obtained using the entire transcriptome. Furthermore, we show that our method can detect differences in the regulation timings between two genes and identify “metastable” states - discrete cell types along the continuous trajectories - that recapitulate known cell types. Ouija therefore provides a powerful complimentary approach to existing whole transcriptome based pseudotime estimation methods. An open source implementation is available at http://www.github.com/kieranrcampbell/ouija as an R package and at http://www.github.com/kieranrcampbell/ouijaflow as a Python/TensorFlow package.
2-Amino-4-methoxy-6-methylpyrimidin-1-ium trifluoroacetate
Authors: Jeevaraj Muthaiah , Edison Bellarmin , Kavitha Savaridasson Jose , Thanikasalam Kanagasabapathy , Britto Sebastian , Balasubramani Kasthuri 
Published: June 2016

In the title molecular salt, C6H10N3O+·C2F3O2−, the pyrimidinium cation is essentially planar, with a maximum deviation of 0.042 (3) Å for all non-H atoms. In the crystal, the cations and anions are linkedviaN—H...O hydrogen bonds, forming a centrosymmetric 2 + 2 aggregate withR22(8) andR42(8) ring motifs. These motifs are further linked through a pair of C—H...O hydrogen bonds into a supramolecular tape along the [101] direction.
An empirical investigation of the relationship between intellectual capital and project success
Authors: Handzic Meliha , Durmic Nermina , Kraljic Adnan , Kraljic Tarik 
Published: June 2016

Purpose– The purpose of this paper is to empirically investigate the relationship between project-specific intellectual capital (IC) and project success in the context of information technology (IT) projects.Design/methodology/approach– Using data collected from surveys of 603 IT professionals across a variety of projects, the authors constructed a structural (structural equation model) model in AMOS to examine the relationships between three dimensions of project-specific IC (project team, project customer and project process) and project success.Findings– The empirical results support the proposition that IC has a positive impact on project success, and thus may be a good indicator of future projects’ performance. More importantly, the authors found out an important mediating role of a project’s structural capital (process) in exploiting its human (team) and relational (customer) capital for realising project success.Research limitations/implications– Interpretation of current results should be considered in light of the following methodological limitations: convenient rather than systematic sampling, use of previously untested measures and prevailing European subjects.Practical implications– These results suggest that project-based organisations need to invest heavily in their project workforce talent and then translate it into superior project practices in order to produce successful IT projects. They also need to maintain close relationships with their project customers and involve them during the entire project process.Originality/value– The current empirical evidence extends the understanding of the role of IC in improving project success and thus helps project-based organisations create and maintain competitive advantage in emerging economies.
The communication of intellectual capital: the “whys” and “whats”
Authors: Wee Janet C.N. , Chua Alton Y.K. 
Published: June 2016

Purpose– The purpose of this paper is twofold: first, to identify motivations that drive communication of IC (CIC); and second, to investigate content and format used in CIC from three perspectives, namely, human capital information, relational capital information and structural capital information.Design/methodology/approach– A global survey was conducted with 200 banks’ senior executives responsible for annual report (AR), followed by content analysis of each bank’s AR.Findings– The study found four motivations of CIC, namely, management responsibility to stakeholders, collective behavior, corporate responsibility and compliance. Content analysis of banks’ AR found structural capital information most prevalent, followed by human capital and relational capital. Five types of formats were analyzed to show the different presentation used in the CIC.Research limitations/implications– Current data source was limited to banking and focussed on English language publications.Practical implications– The study provides regulators insights to forces that either compel or hinder CIC, and updates literature on management’s thinking and priorities in CIC.Originality/value– This study is possibly the first paper that investigates the motivation of CIC for reporting, where IC is an important asset to organizations. The findings on the content and format used in CIC extend existing studies to a wider, global scale.