bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of routine pre-chemotherapy screening with cardiac gated blood pool scan for patients at low risk of anthracycline toxicity
Authors: Chia Puey Ling , Chiang K , Snyder R , Dowling A 
Published: March 2017

Background Anthracycline-based chemotherapy is used in many malignancies. Current recommendations by several groups suggest cardiac monitoring prior to and during anthracycline therapy. We aim to review the usefulness of baseline cardiac screening for left ventricular ejection fraction to assess if it had any impact on chemotherapy decisions in patients to be treated with anthracycline-based regimens or any beneficial effect upon outcomes. Methods We conducted a retrospective three-year audit of cancer patients who underwent GBPS prior to anthracycline (doxorubicin) chemotherapy. Subjects were identified via records from the Department of Nuclear Medicine. Pharmacy dispensing records identified those who received doxorubicin. Patient demographics, cancer type, cardiac risk factors, GBPS ejection fraction (EF), and cumulative anthracycline dose were collected. Results From 1 August 2009 to 31 July 2012, 179 patients underwent GBPS pre-doxorubicin chemotherapy. The mean age was 59 years (range 21–89 years), with 51% being males. Only two patients (1.1%) had an abnormal EF < 50%, while 33 patients (18%) had an EF 51–59% and 144 patients (80%) had EF ≥ 60%. The two patients with reduced baseline EF still received anthracycline-based chemotherapy. All 135 patients without any known cardiovascular risk factors had normal EFs. The total number of patients who received anthracycline chemotherapy during the same period was 207. Thus 28 patients (13%) commenced anthracycline without a prior GBPS. Conclusion Only 1.1% of the screened patients had EF < 50%. These two patients still received doxorubicin chemotherapy despite a compromised EF, as their treating clinicians believed that the benefits of chemotherapy outweighed the risk of potential cardiac toxicity. Our audit questions the practice of routine cardiac evaluation pre-anthracycline screening with GBPS. We propose that routine screening only be requested if cardiac risk factors are present.
Diagnostic performances of manual and automated reticulocyte parameters in anaemic cats
Authors: Paltrinieri Saverio , Fossati Marco , Menaballi Valentina 
Published: March 2017

Objectives The objective of this study was to evaluate the diagnostic performances of manual and instrumental measurement of reticulocyte percentage (Ret%), reticulocyte number (Ret#) and reticulocyte production index (RPI) to differentiate regenerative anaemia (RA) from non-regenerative anaemia (NRA) in cats. Methods Data from 106 blood samples from anaemic cats with manual counts (n = 74; 68 NRA, six RA) or instrumental counts of reticulocytes (n = 32; 25 NRA, seven RA) collected between 1995 and 2013 were retrospectively analysed. Sensitivity, specificity and positive likelihood ratio (LR+) were calculated using either cut-offs reported in the literature or cut-offs determined from receiver operating characteristic (ROC) curves. Results All the reticulocyte parameters were significantly higher in cats with RA than in cats with NRA. All the ROC curves were significantly different ( P <0.001) from the line of no discrimination, without significant differences between the three parameters. Using the cut-offs published in literature, the Ret% (cut-off: 0.5%) was sensitive (100%) but not specific (<75%), the RPI (cut-off: 1.0) was specific (>92%) but not sensitive (<15%), and the Ret# (cut-off: 50 × 10³/µl) had a sensitivity and specificity >80% and the highest LR+ (manual count: 14; instrumental count: 6). For all the parameters, sensitivity and specificity approached 100% using the cut-offs determined by the ROC curves. These cut-offs were higher than those reported in the literature for Ret% (manual: 1.70%; instrumental: 3.06%), lower for RPI (manual: 0.39; instrumental: 0.59) and variably different, depending on the method (manual: 41 × 10³/µl; instrumental: 57 × 10³/µl), for Ret#. Using these cut-offs, the RPI had the highest LR+ (manual: 22.7; instrumental: 12.5). Conclusions and relevance This study indicated that all the reticulocyte parameters may confirm regeneration when the pretest probability is high, while when this probability is moderate, RA should be identified using the RPI providing that cut-offs <1.0 are used.
Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children
Authors: Ersig Anne L. , Schutte Debra L. , Standley Jennifer , Leslie Elizabeth , Zimmerman Bridget , Kleiber Charmaine , Hanrahan Kirsten , Murray Jeffrey C. , McCarthy Ann Marie 
Published: March 2017

Objective: This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure. Study Design: Children aged 4–10 years having an IV catheter insertion were recruited from three Midwestern children’s hospitals. Self-report measures of pain, anxiety, and distress were obtained as well as an observed measure of distress. Samples were collected from children and biological parents for analysis of genomic variation. Genotyped variants had known or suspected association with phenotypes of interest. Analyses included child-only association and family-based transmission disequilibrium tests. Results: Genotype and phenotype data were available from 828 children and 376 family trios. Children were 50% male, had a mean age of 7.2 years, and were 84% White/non-Hispanic. In family-based analysis, one single-nucleotide polymorphism (SNP; rs1143629, interleukin ( IL1B) 1β) was associated with observed child distress at Bonferroni-corrected levels of significance ( p = .00013), while two approached significance for association with high state anxiety (rs6330 Nerve Growth Factor, Beta Subunit, [ NGFB]) and high trait anxiety (rs6265 brain-derived neurotrophic factor [ BDNF]). In the child-only analysis, multiple SNPs showed nominal evidence of relationships with phenotypes of interest. rs6265 BDNF and rs2941026 cholecystokinin B receptor had possible relationships with trait anxiety in child-only and family-based analyses. Conclusions: Exploring genomic variation furthers our understanding of pain, anxiety, and distress and facilitates genomic screening to identify children at high risk of procedural pain, anxiety, and distress. Combined with clinical observations and knowledge, such explorations could help guide tailoring of interventions to limit procedure-related distress and identify genes and pathways of interest for future genotype–phenotype studies.
Disability progression markers over 6–12 years in interferon-β-treated multiple sclerosis patients
Authors: Río Jordi , Rovira Àlex , Tintoré Mar , Otero-Romero Susana , Comabella Manuel , Vidal-Jordana Ángela , Galán Ingrid , Castilló Joaquín , Arrambide Georgina , Nos Carlos , Tur Carmen , Pujal Berta , Auger Cristina , Sastre-Garriga Jaume , Montalban Xavier 
Published: March 2017

Objective: To investigate the association between activity during interferon-beta (IFNβ) therapy and disability outcomes in patients with relapsing–remitting multiple sclerosis (RRMS). Methods: A longitudinal study based on two previously described cohorts of IFNβ-treated RRMS patients was conducted. Patients were classified according to clinical activity after 2 years (clinical cohort) or to clinical and radiological activity after 1 year (magnetic resonance imaging (MRI) cohort). Multivariate Cox models were calculated for early disease activity predicting long-term disability. Results: A total of 516 patients from two different cohorts were included in the analyses. Persistent clinical disease activity during the first 2 years of therapy predicted severe long-term disability (clinical cohort). In the MRI cohort, modified Rio score and no or minimal evidence of disease activity (NEDA/MEDA) did not identify patients with risk of Expanded Disability Status Scale (EDSS) worsening. However, a Rio score ≥ 2 (hazard ratio (HR): 3.3, 95% confidence interval (CI): 1.7–6.4); ≥3 new T2 lesions (HR: 2.9, 95% CI: 1.5–5.6); or ≥2 Gd-enhancing lesions (HR: 2.1, 95% CI: 1.1–4) were able to identify patients with EDSS worsening. Conclusion: Although early activity during IFNβ therapy is associated with poor long-term outcomes, minimal degree of activity does not seem to be predictive of EDSS worsening over 6.7-year mean follow-up.
Immediate transient thrombocytopenia at the time of alemtuzumab infusion in multiple sclerosis
Authors: Ranganathan Usha , Kaunzner Ulrike , Foster Stacyann , Vartanian Timothy , Perumal Jai S 
Published: March 2017

Background: Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). Although Immune thrombocytopenia (ITP) has been reported as a secondary autoimmune phenomenon following alemtuzumab infusion, immediate thrombocytopenia during the infusion has not been reported. Objective: We report transient, reversible, self-limiting acute-onset thrombocytopenia during the first course with alemtuzumab. Results and conclusion: In total, 3 of 22 paitents developed mild self-limited bruising associated with a drop in platelet count from their baseline during the intial 5-day course of alemtuzumab. Upon chart review, all 22 patients who received alemtuzumab developed an immediate mostly asymptomatic drop in platelet count which returned to normal within 2 months post-infusion.
64-Slice CT compared to MRI to clear cervical spine injury in high-risk GCS < 14 blunt trauma patients admitted to the ICU
Authors: McCallum Jessica , McLaughlin Patrick , Hameed Morad , Kanji Hussein D 
Published: March 2017

Objective Clearance of cervical spine injury including ligamentous injury is of paramount importance as results of missed injury may have serious consequences. In obtunded patients, cervical spine clearance is challenging. This study sought to determine whether a negative 64-slice CT scan alone is sufficient to clear cervical spine injury. Patients and methods All consecutive blunt trauma patients admitted to a regional (level 1) trauma center from 1 April 2008 to 31 March 2012 were screened for inclusion in this study. High-risk, GCS < 14, blunt trauma patients were included if they were admitted to the intensive care unit, had a negative 64-slice CT, and MRI of diagnostic quality. GCS was measured at the time of CT scan. Patients with a positive finding on CT scan were excluded. All images were re-interpreted by a trauma radiologist blinded to clinical outcome. Details of missed injuries and clinical impact were reported. The primary outcome was missed clinically significant injury, defined as any injury requiring an additional intervention including continued immobilization or surgery. Results There were 5891 blunt trauma patients admitted to the ICU, 44 of whom met inclusion criteria. Patients had a median injury severity score of 35 and MRI three (2–9) days after CT. Eight of 44 (18%) patients had a positive finding on MRI and five of the findings were clinically insignificant. Three patients (7%) with focal neurologic findings on clinical exam had missed injuries requiring immobilization with a collar. Two of these patients had spine disease, which may have increased their injury risk. Conclusions In high-risk obtunded blunt trauma patients admitted to the ICU, a negative 64-slice CT scan alone is insufficient to clear clinically significant cervical spine injury, with a missed clinically significant injury rate of 7%. When considered with symmetric motor function, a negative 64-slice CT scan may be sufficient. A prospective study is required to confirm these findings.
Is Home-Based, High-Intensity Interval Training Cycling Feasible and Safe for Patients With Knee Osteoarthritis?
Authors: Keogh Justin W. L. , Grigg Josephine , Vertullo Christopher J. 
Published: March 2017

Background: Osteoarthritis (OA) is a degenerative joint disease affecting the knee joint of many middle-aged and older adults. As OA symptoms typically involve knee pain and stiffness, individuals with knee OA are often insufficiently physically active, have low levels of physical function, and are at increased risk of other comorbidities and reduced quality of life. While moderate-intensity continuous training (MICT) cycling is often recommended, little is known about the feasibility, safety, and benefits of high-intensity interval training (HIIT) cycling for this population, even though the feasibility, safety, and benefits of HIIT have been demonstrated in other chronic disease groups. Purpose: The primary objective of this pilot study was to examine the feasibility and safety of home-based HIIT and MICT cycling in middle-aged and older adults with knee OA. A secondary objective was to gain some insight into the relative efficacy of HIIT and MICT for improving health status (pain, stiffness, and disability), muscle function, and body composition in this population. This study protocol is being published separately to allow a detailed description of the research methods, explain the rationale for choosing the methodological details, and to stimulate consideration of the best means to simulate a research protocol that is relevant to a real-life treatment environment. Study Design: Randomized pilot study protocol. Methods: This trial sought to recruit 40 middle-aged and older adults with knee OA. Participants were randomly allocated to either continuous (MICT) or HIIT home-based cycle training programs, with both programs requiring the performance of 4 cycling sessions (approximately 25 minutes per session) each week. Participants were measured at baseline and postintervention (8 weeks). Feasibility and safety were assessed by adherence rate, dropout rate, and number of adverse events. The relative efficacy of the cycling programs was investigated by 2 knee OA health status questionnaires (Western Ontario and McMaster Universities Osteoarthritis Index scale[WOMAC] and the Lequesne Index) as well as the timed up and go, sit to stand, preferred gait speed, and body composition. Discussion: This pilot study appears to be the first study assessing the feasibility and safety of a home-based HIIT training program for middle-aged and older adults with knee OA. As HIIT has been demonstrated to be more effective than MICT for improving aspects of health status, body composition, and/or muscular function in other chronic disease groups, the current study has the potential to improve patient outcomes and inform the design of future randomized controlled trials.
Rescued Children and Unfit Mothers: Dreiser’s Social Work in the Delineator’s Child-Rescue Campaign
Authors: Hainze Emily 
Published: March 2017

Abstract
This essay explores the 1907–11 Child-Rescue Campaign run by the Delineator, a fashion magazine for women edited by Theodore Dreiser. I argue that the campaign mobilized social science to reconceptualize maternity as based in affective expertise rather than biological reproduction. Readers were able to write in to the magazine to adopt “dependent” children whose images and stories were featured in each issue. The essay suggests that these serialized images and “tragic histories” constructed a form of realism in which the Delineator’s readers were invited to act as maternal experts, saving “future citizens” by rescuing them “out of a life of crime” and into white, middle-class domesticity, at the same time articulating the child’s biological mother as criminal and nonwhite.
“I’m Very Happy to Be in the Reality-Based Community”: Alison Bechdel’sFun Home, Digital Photography, and George W. Bush
Authors: Bernstein Robin 
Published: March 2017

AbstractThis essay historicizes Alison Bechdel’s 2006 graphic memoir Fun Home in the context of the presidency of George W. Bush. Bechdel created Fun Home from 1999 through 2005—dates that corresponded with Bush’s campaign, election, and presidency. As Bechdel frequently laments in her serialized comic strip Dykes to Watch Out For, the Bush presidency posited truth as unknowable, facts as infinitely flexible, and faith as constitutive of reality. Fun Home never mentions the president (nor any historical figure or event after the mid-1980s), but the memoir uses newly available digital technology to resist Bush-era “truthiness.” In Fun Home, Bechdel combines digital photography, her body in performance, and hand drawing to create a new form of graphic narrative. This essay draws out Fun Home’s political engagement with the Bush administration and simultaneously claims the proliferation of digital photography as a watershed event in the history of graphic narratives.
Metadata, Metafiction, and the Stakes of Surveillance in Jennifer Egan’s A Visit from the Goon Squad
Authors: Johnston Katherine D. 
Published: March 2017

Abstract
This essay analyzes increasingly ubiquitous data collection and posits that metafiction is especially well suited to grapple with the significance of metadata and data surveillance, given its own preoccupation with watching itself watch. Making a critical intervention in the historically male-centered canon of US metafiction, Egan’s A Visit from the Goon Squad (2010) conscientiously engages the power relations of watching. In the background of the novel and at its chronological center are the 9/11 attacks and also, incidentally, the launch of the iPod. In a sense, these two events structure the novel’s investments in data surveillance. Moreover, to the extent that the novel’s form mirrors a musical album it also forms a network of characters, speaking to the constellation of forces that not only convert analog recordings into digital data, but also translate relationships, habits, and subjectivity into metadata.
Conditions of Critique
Authors: Morgensen Scott L. 
Published: March 2017

Abstract
Indigenous critics are interrogating the violences of modernity as conditions for understanding or debating gender, alongside critical works in trans studies and in queer-of-color, queer diaspora, and women-of-color feminist theories. This essay asks how two-spirit, queer indigenous, and indigenous feminist critiques call scholars in gender studies to ensure that discussions of gender respond to indigenous decolonization and its relationships with antiracist and anticolonial projects. In particular, two-spirit, queer indigenous, and indigenous feminist theories present resurgence as a means to challenge and transform colonial authority. The centering of indigenous epistemologies within resurgence work questions who defines language or the knowable within colonial situations. This essay asks how responding to indigenous resurgence can help to challenge and transform the racial and colonial violences that condition conversations about gender, including those addressing trans and feminist relationships.
Discussing Transnormativities Through Transfeminism
Authors: Ruin  
Published: March 2017

Abstract
This essay explores four aspects of transnormativities through transfeminism. In South Korea, transnormativity is a key issue in transgenderism. However, it has been seriously marginalized in discussions about transgender. Furthermore, mass media, nontrans people, and nontrans social systems, transgender communities, and nontransfeminist scholars re/produce and re/enforce transnormativity by citing hegemonic gender norms. In the same way, they re/enforce and re/produce the hegemonic gender norms by citing transnormativity. In this essay, the author argues that transnormativities include the elimination of temporality, excluding the ways that may threaten the norms, naturalizing the myth that there is natural gender without any instability, and translation without thinking the hierarchy of language.
Broadening the Gendered Polis
Authors: Voli Stefania 
Published: March 2017

Abstract
In the late 1970s to the early 1980s, the Italian transsexual movement began gaining visibility in the public sphere, also making use of the feminist political lexicon. This contamination emerged in the life stories of some trans pioneers, who consider feminism a fundamental element of their political and individual trajectory of subjectivation. In contrast, historiographical reconstructions of Italian feminist movements as well as feminists' accounts never mention the transsexual movement. During battles for the right to change one's gender, transsexuals were supported by only a few feminist members of Left parties. The article analyzes the reasons that prevented Italian feminist and transsexual movements from establishing an open alliance against the patriarchal system deeply rooted in the Italian society of the time.
A Conversation with Jeanne Córdova
Authors: Bettcher Talia M. 
Published: March 2017

Abstract
This interview with long-time Los Angeles–based feminist, lesbian, and butch activist Jeanne Córdova, conducted by TSQ: Transgender Studies Quarterly guest editor and editorial board member Talia Bettcher in June and July 2015, explores the relationship between butch and transgender identities and the place of transgender issues in feminist and lesbian histories and cultures. It pays particular attention to the involvement of transsexual lesbian singer Beth Elliott at the 1973 Lesbian Conference organized by Córdova and others, which became a flashpoint in second-wave feminist dialogs about transsexual involvement in the women's movement and in lesbian feminism.
Pore Clogging of Colloidal Mesoporous Silica Nanoparticles for Encapsulating Guest Species
Authors: Yamamoto Eisuke , Nagata Kouya , Onishi Kenta , Urata Chihiro , Shimojima Atsushi , Wada Hiroaki , Takeoka Shinji , Kuroda Kazuyuki 
Published: March 2017

Abstract
Colloidal mesoporous silica nanoparticles (CMS) are useful as carriers for imaging probes because of their unique features. A simple method for the pore clogging of CMS has been proved by the addition of tetraethoxysilane under weakly basic conditions. The pore clogging of CMS is useful for encapsulation of thermoresponsive dyes.
Cost-effectiveness of early versus delayed antiretroviral therapy in tuberculosis patients infected with HIV in sub-Saharan Africa
Authors: Uthman Rashidah T. , Uthman Olalekan A. 
Published: March 2017

Background:The most challenging issue physicians are facing is the appropriate timing of introducing antiretroviral therapy (ART) along with ongoing tuberculosis (TB) therapy in HIV and TB co-infected patients. This study examined the cost-effectiveness of early versus delayed ART initiation in TB patients, infected with HIV (co-infected patients) in a sub-Saharan Africa setting. Methods:A decision analytic model based on previously published and real-world evidence was applied to evaluate clinical and economic outcomes associated with early versus delayed ART in TB and HIV co-infection. Incremental cost-effectiveness ratio (ICER) was calculated with both costs and quality-adjusted life years (QALYs). Different assumptions of treatment benefits and costs were taken to address uncertainties and were tested with sensitivity analyses. Results:In base case analysis, the expected cost of giving early ART to TB patients infected with HIV was $1372, with a QALY gain of 0.68, while the cost of delayed ART was $955, with a QALY gain of 0.62. The ICER shows $6775 per QALYs, which suggests that it is not as cost-effective, since it is greater than 3 x GDP per capita ($5,086) for sub-Saharan Africa willingness to pay (WTP) threshold. At $10,000 WTP, the probability that early ART is cost effective compared to delayed ART is 0.9933. At cost-effectiveness threshold of $5086, the population expected value of perfect information becomes substantial (≈US$5 million), and is likely to exceed the cost of additional investigation. This suggests that further research will be potentially cost-effective. Conclusions:From the perspective of the health-care payer in sub-Saharan Africa, early initiation of ART in HIV and TB co-infection cannot be regarded as cost-effective based on current information. The analysis shows that further research will be worthwhile and potentially cost-effective in resolving uncertainty about whether or not to start ART early in HIV and TB co-infection.