bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear dynamics of classical spin as Möbius transformation
Authors: Galda Alexey , Vinokur Valerii М. 
Published: April 2017

AbstractThough the overwhelming majority of natural processes occur far from the equilibrium, general theoretical approaches to non-equilibrium phase transitions remain scarce. Recent breakthroughs introduced a description of open dissipative systems in terms of non-Hermitian quantum mechanics enabling the identification of a class of non-equilibrium phase transitions associated with the loss of combined parity (reflection) and time-reversal symmetries. Here we report that the time evolution of a single classical spin (e.g. monodomain ferromagnet) governed by the Landau-Lifshitz-Gilbert-Slonczewski equation in the absence of magnetic anisotropy terms is described by a Möbius transformation in complex stereographic coordinates. We identify theparity-timesymmetry-breaking phase transition occurring in spin-transfer torque-driven linear spin systems as a transition between hyperbolic and loxodromic classes of Möbius transformations, with the critical point of the transition corresponding to the parabolic transformation. This establishes the understanding of non-equilibrium phase transitions as topological transitions in configuration space.
Insecticidal activity of garlic essential oil and their constituents against the mealworm beetle, Tenebrio molitor Linnaeus (Coleoptera: Tenebrionidae)
Authors: Plata-Rueda Angelica , Martínez Luis Carlos , Santos Marcelo Henrique Dos , Fernandes Flávio Lemes , Wilcken Carlos Frederico , Soares Marcus Alvarenga , Serrão José Eduardo , Zanuncio José Cola 
Published: April 2017

AbstractThis study evaluated the insecticidal activity of garlic, Allium sativum Linnaeus (Amaryllidaceae) essential oil and their principal constituents on Tenebrio molitor. Garlic essential oil, diallyl disulfide, and diallyl sulfide oil were used to compare the lethal and repellent effects on larvae, pupae and adults of T. molitor. Six concentrations of garlic essential oil and their principal constituents were topically applied onto larvae, pupae and adults of this insect. Repellent effect and respiration rate of each constituent was evaluated. The chemical composition of garlic essential oil was also determined and primary compounds were dimethyl trisulfide (19.86%), diallyl disulfide (18.62%), diallyl sulfide (12.67%), diallyl tetrasulfide (11.34%), and 3-vinyl-[4H]-1,2-dithiin (10.11%). Garlic essential oil was toxic to T. molitor larva, followed by pupa and adult. In toxic compounds, diallyl disulfide was the most toxic than diallyl sulfide for pupa > larva > adult respectively and showing lethal effects at different time points. Garlic essential oil, diallyl disulfide and diallyl sulfide induced symptoms of intoxication and necrosis in larva, pupa, and adult of T. molitor between 20–40 h after exposure. Garlic essential oil and their compounds caused lethal and sublethal effects on T. molitor and, therefore, have the potential for pest control.
Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors
Authors: Minervini Giovanni , Lopreiato Raffaele , Bortolotto Raissa , Falconieri Antonella , Sartori Geppo , Tosatto Silvio C. E. 
Published: April 2017

AbstractGermline inactivation of the von Hippel-Lindau (VHL) tumor suppressor predisposes patients to develop different highly vascularized cancers. pVHL targets the hypoxia-inducible transcription factor (HIF-1α) for degradation, modulating the activation of various genes involved in hypoxia response. Hypoxia plays a relevant role in regulating cell cycle progression, inducing growth arrest in cells exposed to prolonged oxygen deprivation. However, the exact molecular details driving this transition are far from understood. Here, we present novel interactions between pVHL and the cyclin-dependent kinase inhibitor family CDKN1 (p21, p27 and p57). Bioinformatics analysis, yeast two-hybrid screening and co-immunoprecipitation assays were used to predict, dissect and validate the interactions. We found that the CDKN1 proteins share a conserved region mimicking the HIF-1α motif responsible for pVHL binding. Intriguingly, a p27 site-specific mutation associated to cancer is shown to modulate this novel interaction. Our findings suggest a new connection between the pathways regulating hypoxia and cell cycle progression.
Revealing Hidden Conformational Space of LOV Protein VIVID Through Rigid Residue Scan Simulations
Authors: Zhou Hongyu , Zoltowski Brian D. , Tao Peng 
Published: April 2017

AbstractVIVID(VVD) protein is a Light-Oxygen-Voltage(LOV) domain in circadian clock system. Upon blue light activation, a covalent bond is formed between VVD residue Cys108 and its cofactor flavin adenine dinucleotide(FAD), and prompts VVD switching from Dark state to Light state with significant conformational deviation. However, the mechanism of this local environment initiated global protein conformational change remains elusive. We employed a recently developed computational approach, rigid residue scan(RRS), to systematically probe the impact of the internal degrees of freedom in each amino acid residue of VVD on its overall dynamics by applying rigid body constraint on each residue in molecular dynamics simulations. Key residues were identified with distinctive impacts on Dark and Light states, respectively. All the simulations display wide range of distribution on a two-dimensional(2D) plot upon structural root-mean-square deviations(RMSD) from either Dark or Light state. Clustering analysis of the 2D RMSD distribution leads to 15 representative structures with drastically different conformation of N-terminus, which is also a key difference between Dark and Light states of VVD. Further principle component analyses(PCA) of RRS simulations agree with the observation of distinctive impact from individual residues on Dark and Light states.
Perturbed oral motor control due to anesthesia during intraoral manipulation of food
Authors: Grigoriadis Joannis , Kumar Abhishek , Svensson Peter , Svensson Krister G. , Trulsson Mats 
Published: April 2017

AbstractSensory information from periodontal mechanoreceptors (PMRs) surrounding the roots of natural teeth is important for optimizing the positioning of food and adjustment of force vectors during precision biting. The present experiment was designed to test the hypothesis; that reduction of afferent inputs from the PMRs, by anesthesia, perturbs the oral fine motor control and related jaw movements during intraoral manipulation of morsels of food. Thirty healthy volunteers with a natural dentition were equally divided into experimental and control groups. The participants in both groups were asked to manipulate and split a spherical candy into two equal halves with the front teeth. An intervention was made by anesthetizing the upper and lower incisors of the experimental group while the control group performed the task without intervention. Performance of the split was evaluated and the jaw movement recorded. The experimental group demonstrated a significant decrease in measures of performance following local anesthesia. However, there was no significant changes in the duration or position of the jaw during movements in the experimental and control group. In conclusion, transient deprivation of sensory information from PMRs perturbs oral fine motor control during intraoral manipulation of food, however, no significant alterations in duration or positions of the jaw during movements can be observed.
Anatomy of terminal moraine segments and implied lake stability on Ngozumpa Glacier, Nepal, from electrical resistivity tomography (ERT)
Authors: Thompson Sarah S. , Kulessa Bernd , Benn Douglas I. , Mertes Jordan R. 
Published: April 2017

AbstractMoraine-dammed lakes at debris-covered glaciers are becoming increasingly common and pose significant outburst flood hazards if the dam is breached. While moraine subsurface structure and internal processes are likely to influence dam stability, only few sites have so far been investigated. We conducted electrical resistivity tomography (ERT) surveys at two sites on the terminal moraine complex of the Ngozumpa Glacier, Nepal, to aid assessment of future terminus stability. The resistivity signature of glacier ice at the site (100–15 kΩ m) is more consistent with values measured from cold glacier ice and while this may be feasible, uncertainties in the data inversion introduce ambiguity to this thermal interpretation. However, the ERT data does provide a significant improvement to our knowledge of the subsurface characteristics at these sites, clearly showing the presence (or absence) of glacier ice. Our interpretation is that of a highly complex latero-terminal moraine, resulting from interaction between previous glacier advance, recession and outburst flooding. If the base-level Spillway Lake continues to expand to a fully formed moraine-dammed glacial lake, the degradation of the ice core could have implications for glacial lake outburst risk.
CDS circuit with BLA function for X‐ray CCD applications
Authors: Lu Bo , Chen Yong , Luo Jiajun , Zhou Yumei 
Published: April 2017

Correlated double sampling (CDS) circuits are essential to process the X‐ray charge‐coupled devices (CCDs) that have been used in the modern X‐ray astronomical field. A novel CDS circuit is presented. The innovation of the circuit is that it greatly improves the noise and linearity performances through moving the clamping switch out of the signal path as well as omitting the sampling switch which eliminates the nonlinearity and thermal noise introduced by these switches. Also, a baseline adjustment (BLA) circuit is incorporated so as to make efficient use of the dynamic range of the ADC, making the CDS circuit flexible to interface the CCD operating under a wide range of temperatures. A prototype application‐specific integrated circuit (ASIC) is designed with GlobalFoundries 0.35 μm CMOS process and the experimental results show that with pixel rate varying from 100 kHz to 1 MHz, the integral nonlinearity and equivalent input noise performances are quite consistent, which are better than 27 ppm and 23 μV, respectively, within a dynamic range of 1.5 Vpp. The effective adjustment range of the BLA is at least 2 V, and the power consumption for a single CDS core is 10 mW approximately from a 3.3 V power supply.
Master–slave DC droop control for paralleling auxiliary DC/DC converters in electric bus applications
Authors: Federico Ibanez , Jose Echeverria , Luis Fontan 
Published: April 2017

This study reviews the causes of power losses in a DC/DC converter, relates those losses with efficiency profiles, and details different strategies for maximising efficiency when several converters are placed in parallel. The research is focused on electric bus applications, where several converters are usually connected in parallel in order to fulfil the power requirements of the bus models. In a bus, the low‐voltage DC link (28 V) resembles a microgrid that has some generators (DC/DC converters), an energy storage system (lead–acid batteries) and certain loads. To share the converters’ output power, a droop control is proposed. Furthermore, traditional droop control is improved by adding a master–slave control. The proposed master–slave droop control improves efficiency by more than 3% at low power with no additional hardware. Experimental results show how two 5 kW converters work in parallel using the proposed control.
OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes
Authors: Chu Dinh-Toi , Tao Yang , Taskén Kjetil 
Published: April 2017

AbstractOPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.
In-vitro-Aktivität von Mecillinam gegen Escherichia coli: Urinisolate von Patienten im niedergelassenen Versorgungsbereich in Deutschland
Authors: Kresken Michael , Körber-Irrgang Barbara , Naber Kurt 
Published: April 2017

ZusammenfassungDie Behandlung der akuten unkomplizierten Zystitis soll entsprechend nationaler und internationaler Leitlinien primär mit Fosfomycin-Trometamol, Nitrofurantoin, Nitroxolin oder Pivmecillinam erfolgen. Die weitaus meisten ambulant erworbenen Harnwegsinfektionen werden durch Escherichia coli verursacht. Pivmecillinam (X-SYSTO®) ist das oral verfügbare Prodrug des Penicillin-Derivats Mecillinam, das seit März 2016 wieder auf dem deutschen Markt zur Verfügung steht. Das Ziel der Studie war, den Anteil der Mecillinam-resistenten Stämme bei E. coli-Isolaten vor der Einführung von X-SYSTO® in Deutschland zu ermitteln.Im Rahmen einer In-vitro-Studie wurden die minimalen Hemmkonzentrationen (MHK) von Mecillinam für 494 E.-coli-Urinisolate (einschließlich multiresistenter Stämme) bestimmt. Die Bakterienisolate waren im Zeitraum Oktober bis Dezember 2013 in 25 Laboren von Patienten aus dem niedergelassenen Bereich gesammelt worden. Die Bewertung der Erregerempfindlichkeit als Mecillinam-sensibel (MHK ≤ 8 mg/l) bzw. resistent (MHK > 8 mg/l) erfolgte mithilfe der Grenzwerte des European Committee on Antimicrobial Susceptibility Testing (EUCAST).Die Konzentrationen von Mecillinam, die zur Hemmung von 50 % bzw. 90 % der getesteten Isolate benötigt wurden, betrugen 1 und 4 mg/l für Isolate mit dem Extended-Spektrum-β-Laktamase-Phänotyp und 0,25 und 4 mg/l für die übrigen Isolate. Insgesamt wurden 98 % der Isolate als Mecillinam-sensibel und 2 % als resistent bewertet.Die Ergebnisse stützen die Empfehlung, Pivmecillinam als eine primäre Option zur Erstlinientherapie der akuten unkomplizierten Zystitis zu betrachten.
Entwicklung und Evaluation des Online-Portals herzwegweiser.de - Ein Informationsangebot für die Nachsorge kardiologischer Rehabilitanden und deren Behandler in Berlin-Brandenburg
Authors: Stamm-Balderjahn Sabine , Bartel Susanne , Wilke Kristin , Spyra Karla 
Published: April 2017

Zusammenfassung
Um Rehabilitanden mit Herz-Kreislauferkrankungen aus der Region Berlin-Brandenburg in der Phase-III-Rehabilitation zu unterstützen, wurde das Internet-Portal 'herzwegweiser.de' entwickelt. Es bietet für Patienten neben der Aufklärung über ihr konkretes Krankheitsbild detaillierte Informationen zu Nachsorgeangeboten (z. B. Herzgruppen) in ihrer Wohnumgebung. Für das medizinische und therapeutische Fachkollegium wurde neben spezifischen Informationen (z. B. Behandlungsleitlinien) eine Vermittlungsbörse für Übungsleiter und Ärzte zur Betreuung von Herzgruppen eingerichtet.
Innerhalb eines Mixed-Methods-Designs wurden zunächst leitfadengestützte Interviews geführt, um die Erwartungen und Bedarfe an das Internet-Portal zu ermitteln. Nach Implementation des Portals erfolgte im Hinblick auf Akzeptanz und Benutzerfreundlichkeit eine teilstandardisierte schriftliche Befragung, an der 105 Rehabilitanden und 42 medizinische Fachkollegen teilnahmen. Die Auswertung der Fragebögen wurde mit Häufigkeitsverteilungen, Mittelwertvergleichen und Chi-Quadrat-Tests vorgenommen.
Die Webseite erhielt hohe Zustimmungsquoten in der nutzerseitigen Bewertung. Über 90% der Rehabilitanden bewerteten Inhalt, Aufbau, Design sowie die Suchfunktion des Portals positiv, bei den medizinischen Fachkollegen waren es über 85%. Das Portal weiterempfehlen würden 97% der Rehabilitanden und 95% der Fachkollegen.
Das Internet-Portal kann als Vorbild für die Einrichtung entsprechender Portale für weitere Regionen und ggf. andere Krankheitsbilder dienen.
Pharmacokinetics and Pharmacodynamics of Tofogliflozin (a Selective SGLT2 Inhibitor) in Healthy Male Subjects
Authors: Kasahara-Ito Nahoko , Fukase Hiroyuki , Ogama Yoichiro , Saito Tomohisa , Ohba Yasuhiro , Shimada Sumire , Takano Yasuki , Ichihara Tomoko , Terao Kimio , Nakamichi Noboru , Kumagai Yuji , Ikeda Sachiya 
Published: April 2017

Abstract
Tofogliflozin is a selective oral inhibitor of sodium-glucose co-transporter 2 for treatment of type 2 diabetes mellitus. The pharmacokinetics, pharmacodynamics, and safety of tofogliflozin were investigated in healthy male subjects.
Three studies were conducted: single-ascending dose study (10–640 mg) in 56 Japanese and 24 Caucasian subjects; multiple-ascending dose study (2.5–80 mg once daily for 7 days) in 24 Japanese subjects; and food-effect study (20–40 mg) in 30 Japanese subjects.
Tofogliflozin was absorbed rapidly and eliminated from the systemic circulation with a t1/2 of 5–6 h. Exposure increased dose-proportionally up to 320 mg. Body weight-corrected exposure was similar between Japanese and Caucasian subjects. Urinary excretion of tofogliflozin ranged from 17.1 to 27.4% of dose. Tofogliflozin did not accumulate with once daily administration. Food intake decreased Cmax by approximately 30% but did not change AUC0-inf. Tofogliflozin caused dose-dependent daily urinary glucose excretion (UGE0-24h), but food intake condition at administration did not affect it. The exposure-response relationship between plasma average concentration of tofogliflozin (Cavg) and UGE0-24h fitted Emax model well. There were no serious adverse events leading to discontinuation or episodes of hypoglycemia.
Single and multiple administration of tofogliflozin were generally well tolerated. Exposure to tofogliflozin was dose-proportional up to 320 mg and did not accumulate with multiple once-a-day administration. The model suggests more than 100 ng/mL Cavg corresponding to the dose of between 20 and 40 mg leads to almost maximum effect of tofogliflozin.
Votes at Work in Britain: Shareholder Monopolisation and the ‘Single Channel’
Authors: McGaughey Ewan 
Published: April 2017

Abstract
Why do shareholders monopolise voting rights in UK companies, and are trade unions the only way to get meaningful workplace representation? In 1967 a Labour Party policy document first coined the phrase that a ‘single channel’ for representation should ‘in the normal’ case mean trade unions. Since then, it has been said the labour movement embraced an ‘adversarial’ rather than a ‘constitutional’ conception of corporations, neglecting legal rights to worker voice in enterprise governance. This article shows that matters were not so simple. It explains the substantial history of legal rights to vote in British workplaces, and competition from the rival constitutional conception: employee share schemes. The UK has the oldest corporations – namely universities – which have consistently embedded worker participation rights in law. Britain has among the world’s most sophisticated ‘second channel’ participation rights in pension board governance. Developing with collective bargaining, it had the world’s first private corporations with legal participation rights. Although major plans in the 1920s for codetermination in rail and coal fell through, it maintained a ‘third channel’ of worker representatives on boards during the 20th century in numerous sectors, including ports, gas, post, steel, and buses. At different points every major political party had general proposals for votes at work. The narrative of the ‘single channel’ of workplace representation, and an ‘adversarial’ conception of the company contains some truth, but there has never been one size of regulation for all forms of enterprise.
Salve and Burdock: A Safe, Effective Amish Remedy for Treatment of Traumatic Wounds?
Authors: Flurry Mitchell D. , Herring Kelsie L. , Carr Logan W. , Hauck Randy M. , Potochny John D. 
Published: April 2017

ABSTRACT

BACKGROUND:
Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing.

METHODS:
A retrospective chart review was performed on 6 Amish patients treated with salve and burdock leaves instead of skin grafting following complex traumatic wounds to determine whether the traditional treatment incurred any patient harm.

RESULTS:
The time of wound epithelialization and healing complications were noted, among other data points. Time to full epithelialization ranged from 1 to 7 months. Time to full wound healing was proportional to wound size.

CONCLUSIONS:
Although the treatment presented here is unconventional, it did not cause harm to the patients studied.
Eyelid Reconstruction Using Oral Mucosa and Ear Cartilage Strips as Sandwich Grafting
Authors: Yamamoto Naoto , Ogi Hiroyuki , Yanagibayashi Satoshi , Yoshida Ryuichi , Takikawa Megumi , Nishijima Akio , Kiyosawa Tomoharu 
Published: April 2017

Background:
The eyelid structure can be divided into an inner layer and an outer layer. Reconstruction of a full-thickness eyelid defect is accomplished by full-thickness composite tissue transfer or combined layered reconstruction. We present a new technique for inner layer reconstruction using ear cartilage and oral mucosa.

Methods:
The oral mucosa graft is harvested from the inner side of the lower lip to fit the defect size and shape. The ear cartilage graft is harvested as a rectangular strip. The harvested mucosa is sutured to the defect margin and the cartilage strip graft is interposed to the defect. Finally, the outer layer of the defect is covered with skin flaps. Consequently, the ear cartilage graft is sandwiched between the mucosa graft and the skin flap.

Results:
We used this technique for the reconstruction of 13 full-thickness eyelid defects of various locations, sizes, and shapes. Ten cases involved the lower eyelid, 2 cases involved the lower eyelid including the medial canthus, and 1 case involved the upper eyelid. The oral mucosa graft survived in all patients. The reconstructions were successful and there were no postoperative reports of conjunctival or corneal irritation.

Conclusions:
The present technique using a combination of an ear cartilage strip graft and oral mucosa graft is an easy and versatile technique for reconstruction of inner layer eyelid defects. We believe that the beneficial effects of tears, which are richly oxygenated, improved survival of the grafted mucosa.