bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping
Authors: Palenzuela Rocío , Gutiérrez Yolanda , Draffin Jonathan E. , Lario Argentina , Benoist Marion , Esteban José A. 
Published: September 2017

The regulated transport of AMPA-type glutamate receptors (AMPARs) to the synaptic membrane is a key mechanism to determine the strength of excitatory synaptic transmission in the brain. In this work, we uncovered a new role for the microtubule-associated protein MAP1B in modulating access of AMPARs to the postsynaptic membrane. Using mice and rats of either sex, we show that MAP1B light chain (LC) accumulates in the somatodendritic compartment of hippocampal neurons, where it forms immobile complexes on microtubules that limit vesicular transport. These complexes restrict AMPAR dendritic mobility, leading to the intracellular trapping of receptors and impairing their access to the dendritic surface and spines. Accordingly, increasing MAP1B-LC expression depresses AMPAR-mediated synaptic transmission. This effect is specific for the GluA2 subunit of the AMPAR and requires glutamate receptor interacting protein 1 (GRIP1) interaction with MAP1B-LC. Therefore, MAP1B-LC represents an alternative link between GRIP1-AMPARs and microtubules that does not result in productive transport, but rather limits AMPAR availability for synaptic insertion, with a direct impact on synaptic transmission.SIGNIFICANCE STATEMENTThe ability of neurons to modify their synaptic connections, known as synaptic plasticity, is accepted as the cellular basis for learning and memory. One mechanism for synaptic plasticity is the regulated addition and removal of AMPA-type glutamate receptors (AMPARs) at excitatory synapses. In this study, we found that a microtubule-associated protein, MAP1B light chain (MAP1B-LC), participates in this process. MAP1B-LC forms immobile complexes along dendrites. These complexes limit intracellular vesicular trafficking and trap AMPARs inside the dendritic shaft. In this manner, MAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane, contributing to downregulating synaptic transmission.
Uso del balón cervical vs. prostaglandinas endocervicales para la inducción del parto en embarazo a término: revisión breve de literatura
Authors: Aguilar Sánchez Pamela , Mora Gómez Raquel 
Published: September 2017

Las prácticas del cuidado del embarazo y el parto varían ampliamente entre los países, las instituciones y los diferentes equipos encargados del cuidado obstétrico: en este contexto con prácticas tan diversas, la práctica clínica basada en la evidencia permite que el accionar de los profesionales encargados del cuidado obstétrico se fundamente en la mejor evidencia disponible. El objetivo del presente estudio es analizar la mejor evidencia científica disponible sobre los efectos adversos del uso del balón cervical durante y posterior a la labor de parto, en comparación con el uso de prostaglandinas endocervicales para la inducción del parto en mujeres con embarazo a término. La secuencia de etapas para la recolección de la información se inició con la aplicación del mapa de búsqueda en las bases de datos MEDLINE, PUBMED y COCHRANE LIBRARY, a partir de los siguientes criterios de filtro de información: artículos publicados entre los años 2010 al 2015, mujeres gestantes de cualquier edad, únicamente se incluyó estudios como ensayos aleatorizados controlados, revisiones sistemáticas, meta-análisis o guías de práctica clínica y de preferencia artículos científicos en idioma inglés o portugués. Esta búsqueda y análisis de la evidencia encontrada se realizó durante los meses de abril y mayo del año 2015 por dos revisores. Los resultados obtenidos para el análisis crítico fueron revisados minuciosamente a través de la plataforma informática FCL 2.0 con las plantillas de ensayo clínico y revisión sistemática incluidas en los anexos. Se concluye que la utilización del balón endocervical comparado con el uso de prostaglandinas endocervicales presenta menos efectos adversos de manera específica durante la labor del parto. En relación con los efectos adversos posteriores, no se encuentra mayor diferencia entre uno u otro método
Effect of phototherapy on serum calcium level in term newborns
Authors: Ignatious Rozario Cyril , S. Pillai Preethi , T. Ranamol 
Published: September 2017

Background: Hyperbilirubinemia is one of the most prevalent problems in neonates. Jaundice is observed during first week of life in approximately 60% of term neonates and 80 % of preterm neonates. Phototherapy is one of the routine methods for management of hyperbilirubinemia. The aim of this study is to assess the effect of phototherapy on serum calcium level in term newborns with neonatal hyperbilirubinemia who undergo phototherapy and to find out the association between effect of phototherapy on serum calcium level and birth weight, postnatalage, type of feeding and blood group incompatibility.Methods: 100 newborns with neonatal hyperbilirubinemia admitted in newborn nursery were selected for the study. Serum calcium estimation was done before phototherapy. All newborns were subjected to double surface phototherapy. After 48 hours of phototherapy serum calcium was estimated and compared with earlier value.Results: Out of 100 newborns studied 67 babies had a decrease in serum calcium level after 48 hrs of phototherapy. And this reduction in calcium level was found to be statistically significant (p value <0.001). Only 3 babies developed hypocalcemia (serum calcium <7 mg/dl). None of them were symptomatic. There was no significant association between reduction in serum calcium level and birth weight, postnatalage, type of feeding and blood group incompatability.Conclusions: There is signiticant reduction in serum calcium level after phototherapy but risk of hypocalcemia is low in healthy full-term neonates. No significant association was found between reduction in serum calcium level and birth weight, postnatal age,type of feed, and blood group incompatibility.
A Gamificação como Estratégia de Engajamento e Motivação na Educação
Authors: Tolomei Bianca Vargas 
Published: September 2017

O fenômeno da gamificação tem ampliado a criação de experiências e pesquisas em diversas áreas como marketing, treinamentos corporativos e na Educação, que é o foco deste artigo. Aqui serão abordadas perspectivas teóricas no intuito de demonstrar que os elementos da gamificação aplicados em atividades de aprendizagem podem proporcionar o aumento do engajamento e da motivação em atividades educacionais. Para isso foram selecionados trabalhos de cunho bibliográfico e exemplos de experiências reais que exploram o tema e que fazem uma análise crítica pertinente ao assunto. Foi possível perceber carência de literatura sobre o tema e, além disso, que a gamificação é muitas vezes entendida como um jogo, por ter sua vertente originada no design de jogos. É constatado que, para entender a utilização da gamificação, precisamos primeiramente entender o que é um jogo e suas funções, para depois estabelecer sua funcionalidade e empregabilidade na Educação.Palavras-chave: Gamificação, Aprendizagem, Educação online.The Gamification as a Strategy for Engagement and Motivation in Education Abstract The gamification phenomenon has expanded creating experiences and research in areas such as marketing, corporate training and also in education, which is the focus of this article. It will be addressed theoretical perspectives in order to demonstrate that gamification elements applied in learning activities can provide engagement and motivation growth in educational activities. For this we selected bibliographical works and examples of real experiences that explore the theme and make critical analysis relevant to the subject. It was revealed a lack of literature on the subject and, moreover, that gamification is often understood as a game, due to its aspects related to game design. It is known that, in order to understand the use of gamification, we first need to understand what is a game and its functions, and then establish its functionality and usability in education.Keywords: Gamification, Learning, Online education.
Educação Presencial versus EaD: Perspectivas dos Alunos dos Cursos de Serviços Públicos e Administração
Authors: Fonseca Cezar , Fernandes Catarina Costa 
Published: September 2017

O presente artigo visa analisar, na perspectiva dos alunos dos cursos deServiços Públicos e Administração, ambos na modalidade EaD, do Instituto Federal do Paraná: IFPR/Campus Foz do Iguaçu, quais as principais divergências e convergências quanto a estrutura pedagógica, metodologia de ensino, relação professor-aluno e avaliação do ensino-aprendizagem que existem entre a modalidade ensino a distância frente à modalidade presencial. Os alunos realizaram um comparativo entre as modalidades, por meio de suas experiências vividas na modalidade presencial em estudos anteriores. Também se verificaram, a partir dessa perspectiva, as desvantagens e vantagens que impactam o desenvolvimento da modalidade na visão do aluno, com quesitos de dificuldades encontradas. O estudo apontou que há 75%, 67%, 69% e 53% de convergência para estrutura pedagógica, metodologia de ensino, relação professor-aluno e ensino-aprendizagem, respectivamente.Palavras-chave: Educação a Distância, Educação presencial, Perspectiva do aluno EaD. Face-to- face Versus EaD: Perspectives of Students in Public Service Courses and AdministrationAbstractThe present article aims to analyze, from the perspective of the students ofthe Public Service and Administration courses, both in the EaD (Distance Learning) modality of the Federal Institute of Paraná - IFPR/Foz do Iguaçu Campus, what the main divergences and convergences are regarding pedagogical structure, teaching methodology, teacher-student relationship and teaching-learning evaluation that exist between modality of distance learning versus face-to- face modality. The students have made a comparison between the modalities, through their experiences lived in the classroom mode in previous studies. It has been also observed, from this perspective, the disadvantages and advantages that have impacted on the development of the modality in the student&#39;s vision, with problems encountered. Thestudy has pointed out that there are 75, 67, 69 and 53% convergence for,pedagogical structure, teaching methodology, teacher-student relationship andteaching-learning respectively.Keywords: Distance learning, Face-to- face education, EaD (Distance Learning)student perspective.
Consórcio Cederj: A História da Construção do Projeto
Authors: Bielschowsky Carlos Eduardo 
Published: September 2017

O Estado do Rio de Janeiro, juntamente com as universidades públicas (federais e estaduais) sediadas neste estado, iniciou no período 1999-2000 a construção do consórcio Cederj. Neste artigo são apresentados alguns aspectos importantes que influenciaram decisivamente no planejamento inicial desse projeto, tais como o contexto histórico da Educação a Distância no Brasil e em outros países, a situação do ensino superior no Brasil à época, mostrando que a metodologia de Educação a Distância passava por uma transição entre instituições tradicionais? e instituições que iniciavam oferta de cursos com e-learning sob influência das novas tecnologias. É também descrito o desenho acadêmico do projeto inicial, com a distribuição de oferta de cursos semipresenciais no ensino superior nas instituições públicas e os resultados da implementação dos primeiros cursos, que geraram grandes desafios para a continuidade do projeto, considerado um dos casos mais bem-sucedidos dos dias atuais.Palavras-chave: Consórcio Cederj, Fundação Cecierj, História da EaD no Brasil, Darcy Ribeiro, e-learning, Ensino superior, Educação pública. Cederj Consortium: The History of Project ConstructionAbstractThe State of Rio de Janeiro, together with the public universities (federal and state ones) in this referred state, began in 1999-2000 the construction of the Cederj consortium. This article presents some important aspects that influenced decisively the initial planning of this project, such as the historical context of Distance Education in Brazil and in other countries, the situation of higher education in Brazil at the time, showing that the methodology of Distance Education went through a transition between "traditional" institutions and institutions that started offering e-learning courses under the influence of new technologies. It is also described the academic design of the initial project, with the distribution of the offer of blended courses in higher education in public institutions and the results of the implementation of the first courses, which generated great challenges for the continuity of the project, considered one of the most well case nowadays.Palavras-chave: Cederj consortium, Cecierj Foundation, History of EaD in Brazil, Darcy Ribeiro, e-learning, Higher education, Public education.
Casas rurais mineiras e do nordeste paulista
Authors: Benincasa Vladimir 
Published: September 2017

Trata da arquitetura das fazendas de gado abertas entre o final do século XVIII e meados do século XIX, na região compreendida entre os rios Moji-Guaçu e Grande, no nordeste paulista, cujo povoamento se deu ao longo do Caminho de Goiás por pessoas originárias das regiões auríferas e do sul de Minas Gerais. A região conserva muitas fazendas abertas então, cujas atividades originais estavam ligadas à pecuária extensiva de gado bovino, à criação de suínos e muares e à agricultura destinadas, principalmente, a suprir o Quadrilátero do Açúcar (região compreendida entre Campinas, Sorocaba, Itu e Moji-Mirim) e as regiões cafeicultoras do Vale do Paraíba, e as tropas que passavam em direção às minas auríferas de Goiás e Cuiabá. Compara essa arquitetura “paulista” com a da região de origem de seus construtores em Minas Gerais.
INHIBITION OF THE GROWTH OF TOLERANT YEAST Saccharomyces cerevisiae STRAIN I136 BY A MIXTURE OF SYNTHETIC INHIBITORS
Authors: Riyanti Eny Ida , Listanto Edy 
Published: September 2017

<p>Biomass from lignocellulosic wastes is a potential source for biobased products. However, one of the constraints in utilization of biomass hydrolysate is the presence of inhibitors. Therefore, the use of inhibitor-tolerant microorganisms in the fermentation is required. The study aimed to investigate the effect of a mixture of inhibitors on the growth of Saccharomyces cerevisiae strain I136 grown in medium containing synthetic inhibitors (acetic acid, formic acid, furfural, 5-hydroxymethyl furfural/5-HMF, and levulinic acid) in four different concentrations with a mixture of carbon sources, glucose (50 g.l-1) and xylose (50 g.l-1) at 30oC. The parameters related to growth and fermentation products were observed. Results showed that the strain was able to grow in media containing natural inhibitors (BSL medium) with µmax of 0.020/h. Higher level of synthetic inhibitors prolonged the lag phase, decreased the cell biomass and ethanol production, and specific growth rate. The strain could detoxify furfural and 5-HMF and produced the highest ethanol (Y(p/s) of 0.32 g.g-1) when grown in BSL. Glucose was utilized as its level decreased in a result of increase in cell biomass, in contrast to xylose which was not consumed. The highest cell biomass was produced in YNB with Y (x/s) value of 0.25 g.g-1. The strain produced acetic acid as a dominant side product and could convert furfural into a less toxic compound, hydroxyl furfural. This robust tolerant strain provides basic information on resistance mechanism and would be useful for bio-based cell factory using lignocellulosic materials. </p>
Performansi Implementasi Numerik Metode Pseudo Spectral pada Model Gelombang 1D Boussinesq
Authors: Adytia Didit 
Published: September 2017

<p>In the design of a numerical wave tank, it is necessary to use an accurate wave model as well as to choose an accurate and efficient numerical scheme for implementing the model. In this paper, we use a Pseudo-Spectral (PS) implementationfor a wave model so called Variational Boussinesq Model. The implementation is aimed to obtain a higher time efficiency in the calculation of wave simulations. The performance of the PS implementation is compared in CPU-time with a Finite Element (FE) implementation of the wave model for simulating a focusing wave group. Results of both implementations give a good agreement with wave data from laboratory experiment. The PS-implementation gives more efficient CPU-time compared to the FE-implementation.</p>
Salud mental con perspectiva de género
Authors: Sol-Pastorino María , Vanegas-López Jairo , Florenzano-Urzúa Ramón 
Published: September 2017

Señor editor: Enviamos los resultados preliminares de una investigación sobre salud mental y género llevada a cabo en Chile, según las puntuaciones obtenidas en una evaluación global de salud mental (para la cual se utilizó el cuestionario de resultados OQ-45.2, que mide sintomatología, rol social y relaciones interpersonales), realizada a hombres y mujeres con un diagnóstico de trastorno afectivo, tratados en el servicio de psiquiatría del Hospital del Salvador de Santiago de Chile...
Knowledge, attitudes and practices of personal protective measures among hemodialysis nurses in Benghazi
Authors: Abdulmalek L 
Published: September 2017

Abstract
Background: This study intended to assess knowledge, attitudes, and practices regarding standard precautions concerning health care-associated infections (HAIs) among hemodialysis nurses in hemodialysis centers in Benghazi.
Methods: the study was a cross sectional study carried out during the period from 1-3-2014 till 30-9-2014. The data was gathered from hemodialysis nurses in hemodialysis centers in Benghazi by using a questionnaire and by direct interview.
Results: There were a total of 59 hemodialysis nurses in hemodialysis centers in Benghazi. All agreed to participate in the study. Although 92% of the nurses knew that their hands could be a source of health care-associated infections, but only 52% of nurses washed their hands before contacting another patient. Gloves were actually used by 98% of the nurses. 46% of the nurses were usually wearing masks when contacting a patient. Books and journals were the main source of information about (HAI) among 52% of the nurses.
Conclusion: The nurses' knowledge of health care-associated infections did not modify their adherence to hand hygiene practices. This study recommend training programs for hemodialysis nurses about promoting higher hand hygiene standards and potential use of personal protective measures during their shifts in hemodialyais centers.
Pengukuran Kinerja Efektif Departemen Pengembangan Sistem Informasi dengan Metode Balanced Scorecard pada PT. Xyz
Authors: Suryani Eli , Fadli Muhammad 
Published: September 2017

Department of Information System Development at PT XYZ becomes a trigger in the movement of the Information Technology Development of the company. However it is not merely the fastest, the biggest or the most completed project that determine the success, but the most important is to align with the business strategy due to achieve the company’s goal and objective. Recognizing the performance does not only need a measurement system but also right measurements. The purpose of the study is to design an effective Key Performance Indicator in Departement of Information System Development that is aligned with current indicators to measure the success of company’s strategy execution. The choosen indicators are cascaded from company’s strategy map and information technology strategy map. The design uses balanced scorecard method according to data and information collected from executive interview, focus group discussion and workshop with the key persons in IT organization. Balanced scorecard method provides the integration of financial and non-fianncial factor for measurements. It allows different level formulation with same performance indicator flexibly. Recently, Department of Information System Development can monitor and develop its performance directionally.
Penentuan Daya Cerna Protein In Vitro Ikan Bawal (Colossoma Macropomum) pada Umur Panen Berbeda
Authors: Saputra Dede 
Published: September 2017

Digestibility is part of the sample consumed and not released into the feces. This study discusses about the protein digestibility of tambaqui fish (Colossoma macropomum) at different ages and sizes in vitro. Protein digestibility is the ability of the organisms to break down proteins into simple molecular compounds. At the initial stage, all samples used were dried, then distilled water at pH 8 added, and later the mixture was homogenized for three minutes. After the mixture was homogeneous, enzymes and distilled water were added. Samples were then centrifuged and the absorbance of the sample was measured using absorption spectrophotometry. The results obtained during the observations showed that the digestibility of proteins in the casein showed a value of 100%, small pomfret fish for 28.37%, pomfret fish at 58.42%, and large pomfret fish amount to 88.39%. This shows the larger size of the fish, then the digestibility of protein will be higher. In addition, the lower the pH, the protein digestibility will be higher for hydrolysis of proteins requires an acidic environment of pH conditions.
Tinjauan Format Ideal, Fungsi dan Estetika Buletin Binus University
Authors: Wulandari Sari 
Published: September 2017

Buletin BINUS is a communication medium that connects Binusian, contains information about events held at BINUS. Figures of this bulletin is BINUS University, either through the appearance and content of the newsletter itself, where the messages contained in explicit and implicit so that eventually will form a picture or image in the mind of the reader. This study examines the function and aesthetics in a format specific BULETIN which was published in 2008 and 2009. Reviewes carried out refers to the disciplines of Visual Communication Design. The purpose and benefits of this research is to use scientific and practical layout Buletin BINUS University and research results in the form of suggestions are ideal application of design elements for publication Buletin BINUS University, which is based on ease of implementation, the function of information, the effectiveness of media communications, and aesthetics. It is expected that the information in it will be delivered properly, can bring out the character right BINUS University and establish a positive image in the mind of the reader.
Paradigma Baru Dalam Museum Seni dan Budaya Jawa Ullen Sentalu
Authors: Nediari Amarena 
Published: September 2017

The existence of the museum building as conservation collection of historic objects often give the impression that the museum is an ancient building, dark and disheveled. While the new paradigm in the management of the museum is a museum not only as a place to store historical objects, but need to present the collection in an attractive package so that visitors interested in coming back again to the museum. Museum of art and culture of Java Ullen Sentalu, in Kaliurang has provided a new insight to the culture, especially Javanese culture in the family palace of Yogyakarta and Solo Palace. The main attraction of this Sentalu Ullen is to deliver information about the historic collection from the family palace is presented as a whole, so that leaves a deep impression for visitors. This museum has given the world a new concept in museums in Indonesia, which certainly can be applied to other museums in Indonesia.