bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Dysmenorrhea: A Relaxation Therapy Program
Authors: Ben‐Menachem Michael 
Published: January 2017

ABSTRACTRelaxation therapy was used to treat ten high school‐aged girls suffering from dysmenorrhea. A self‐judgment sheet was used to evaluate the results of the therapy. The treatment group improved significantly (p < 0.01) on the symptoms “cramps” and “nausea,” and on “difficult to concentrate,” “unambitious” and “being irritable” (p < 0.05).
Cul‐de‐sac Insufflation: An Easy Alternative Route for Safely Inducing Pneumoperitoneum
Authors: van Lith Dirk A. F. , van Schie Kees J. , Beekhuizen Willem , Plessis Marijke du 
Published: January 2017

ABSTRACTSince 1977, routine cul‐de‐sac insufflation to achieve a pneumoperitoneum for laparoscopy was performed on 350 women under local anesthesia. A van Schie/van Lith intrauterine tenaculum, used together with a self‐retaining Trelat speculum, guaranteed maximum stretching of the posterior vaginal fault and fixation of the anteflexed uterus necessary for an accurate 1‐cm deep penetration of a pneumoperitoneum needle into the cul‐de‐sac. The correct position of the tip of the needle was determined precisely by means of two manometers. The failure rate in the first study of 195 procedures was 3.6% and that in the following 155 cases was 1.9%. There were no serious operative complications. The authors recommend the cul‐de‐sac insufflation approach for inducing pneumoperitoneum as the technique of choice.
Quinacrine Hydrochloride Pellets: Preliminary Data on a Nonsurgical Method of Female Sterilization
Authors: Zipper Jaime , Cole Lynda Painter , Goldsmith Alfredo , Wheeler Robert , Rivera Mirtha 
Published: January 2017

ABSTRACTThe efficacy of transcervical insertions of quinacrine hydrochloride pellets to produce tubal occlusion has been evaluated in a study of 139 women in Santiago, Chile. At one year, the pregnancy rate was 3.1%, an acceptable rate for a nonsurgical method of female sterilization.
Folate Status in Pregnant Chinese Women in Hong Kong
Authors: Tso S. C. , Wong R. L. C. 
Published: January 2017

ABSTRACTHematologic and folate studies were carried out in 116 pregnant Chinese women in Hong Kong. Mean serum folate values fell progressively with pregnancy reaching subnormal levels during the puerperium. Mean red‐cell folate values remained normal or high throughout, but showed a significant fall after delivery in women who carried out breast‐feeding. Individually, 18 women showed hematologic abnormalities compatible with folate deficiency, but only four had subnormal red‐cell folate values satisfying the strict criterion of folate deficiency, giving an overall frequency of 3.4%. Compared to primigravidae and other multiparae, gravida 2 women appeared to be at highest risk of folate deficiency.
Phosphofructokinase‐P Modulates P44/42 MAPK Levels in HeLa Cells
Authors: Cardim Pires Thyago Rubens , Albanese Jamille Mansur , Schwab Michael , Marette André , Carvalho Renato Sampaio , Sola‐Penna Mauro , Zancan Patricia 
Published: January 2017

ABSTRACTIt is known that interfering with glycolysis leads to profound modification of cancer cell proliferation. However, energy production is not the major reason for this correlation. Here, using HeLa cells as a model for cancer, we demonstrate that phosphofructokinase‐P (PFK‐P), which is overexpressed in diverse types of cancer including HeLa cells, modulates expression of P44/42 mitogen‐activated protein kinase (MAPK). Silencing of PFK‐P did not alter HeLa cell viability or energy production, including the glycolytic rate. On the other hand, silencing of PFK‐P induced the downregulation of p44/42 MAPK, augmenting the sensitivity of HeLa cells to different drugs. Conversely, overexpression of PFK‐P promotes the upregulation of p44/42 MAPK, making the cells more resistant to the drugs. These results indicate that overexpression of PFK‐P by cancer cells is related to activation of survival pathways via upregulation of MAPK and suggest PFK‐P as a promising target for cancer therapy. J. Cell. Biochem. 118: 1216–1226, 2017. © 2016 Wiley Periodicals, Inc.
A Cross‐Lagged Panel Study of Dissociation and Posttraumatic Stress in a Treatment‐Seeking Sample of Survivors of Childhood Sexual Abuse
Authors: Murphy Siobhan , Elklit Ask , Murphy Jamie , Hyland Philip , Shevlin Mark 
Published: January 2017

ObjectiveThe current prospective study assessed the temporal relations between dissociation and posttraumatic stress (PTS) in a sample of treatment‐seeking female survivors of childhood sexual abuse. PTS refers to symptoms associated with posttraumatic stress disorder (PTSD) in the absence of a clinical diagnosis of PTSD.MethodInitial assessment was on average 23 years after the onset of abuse (N = 405), and participants were followed‐up after 6 months (N = 245) and 12 months (N = 119).ResultsFindings indicated that dissociative experiences and PTS were highly correlated within each wave of data collection. Cross‐lagged panel analysis revealed that at each assessment period dissociative symptoms and PTS levels, respectively, were primarily explained by scores on the same variable at the previous assessment period. Although further reciprocal relations between dissociation and PTS were evident, these associations were relatively weak in magnitude.ConclusionCurrent results provide important insights into the temporal relations between dissociative symptoms and PTS. The high correlations between dissociative experiences and PTS several years after trauma exposure have important clinical implications that may affect their treatment and trauma recovery.
Exploring the role of pharmacists in private primary healthcare clinics in Malaysia: the views of general practitioners
Authors: Saw Pui San , Nissen Lisa , Freeman Christopher , Wong Pei Se , Mak Vivienne 
Published: January 2017

AbstractBackgroundPrivate general practitioners (GPs) in Malaysia mainly operate solo practices with little interdisciplinary collaboration or co‐ordination with other healthcare providers which potentially fragments and limits patient care. Pharmacists as medication experts can contribute to the private primary care sector using their influence to ensure quality use of medicines.AimTo explore the views of private GPs in Malaysia on integration of pharmacists into private primary healthcare clinics.MethodA combination of purposive and snowballing sampling was used to recruit private sector GPs to participate in focus groups and semi‐structured interviews in Malaysia. Sessions were audio recorded, transcribed verbatim and thematically analysed using NVivo 10.ResultsThirteen private GPs participated in one focus group and ten semi‐structured interviews. Four major themes were identified: (i) poor understanding of pharmacists’ roles; (ii) readiness to accept pharmacists in private primary healthcare clinics; (iii) lack of confidence and trust in pharmacists; and (iv) perceived increased costs with pharmacist integration. Results indicated participants’ views and acceptance were largely influenced by the amount of exposure and experience they had working alongside pharmacists. Participants viewed a lack of confidence in pharmacists and increase in costs associated with an employed pharmacist within private primary healthcare clinics as barriers to integration.ConclusionPrivate GPs expressed reservations toward this new model due to the lack of understanding of pharmacists’ roles and responsibilities. There is a need for awareness among private GPs on pharmacists’ roles to improve their acceptance of the integration of pharmacists into private primary healthcare clinics in Malaysia.
Increased protein content of chickpea (Cicer arietinum L.) inoculated with arbuscular mycorrhizal fungi and nitrogen‐fixing bacteria under water deficit conditions
Authors: Oliveira Rui S , Carvalho Patrícia , Marques Guilhermina , Ferreira Luís , Nunes Mafalda , Rocha Inês , Ma Ying , Carvalho Maria F , Vosátka Miroslav , Freitas Helena 
Published: January 2017

AbstractBACKGROUNDChickpea (Cicer arietinum L.) is a widely cropped pulse and an important source of proteins for humans. In Mediterranean regions it is predicted that drought will reduce soil moisture and become a major issue in agricultural practice. Nitrogen (N)‐fixing bacteria and arbuscular mycorrhizal (AM) fungi have the potential to improve plant growth and drought tolerance. The aim of the study was to assess the effects of N‐fixing bacteria and AM fungi on the growth, grain yield and protein content of chickpea under water deficit.RESULTSPlants inoculated with Mesorhizobium mediterraneum or Rhizophagus irregularis without water deficit and inoculated with M. mediterraneum under moderate water deficit had significant increases in biomass. Inoculation with microbial symbionts brought no benefits to chickpea under severe water deficit. However, under moderate water deficit grain crude protein was increased by 13%, 17% and 22% in plants inoculated with M. mediterraneum, R. irregularis and M. mediterraneum + R. irregularis, respectively.CONCLUSIONInoculation with N‐fixing bacteria and AM fungi has the potential to benefit agricultural production of chickpea under water deficit conditions and to contribute to increased grain protein content. © 2017 Society of Chemical Industry
Simultaneous Determination of Four Triterpenoid Saponins in Aralia elata Leaves by HPLC‐ELSD Combined with Hierarchical Clustering Analysis
Authors: Sun Yichun , Li Baimei , Lin Xiaoting , Xue Juan , Wang Zhibin , Zhang Hongwei , Jiang Hai , Wang Qiuhong , Kuang Haixue 
Published: January 2017

AbstractIntroductionAralia elata leaves are known to have several biological activities, including anti‐arrythmia, antitumor, anti‐inflammatory, anti‐fatigue, antimicrobial and antiviral effects. Our previous study found that triterpenoid saponins from the leaves of A. elata had antitumor effects. Quantification of the triterpenoids is important for the quality control of A. elata leaves.ObjectiveTo establish high‐performance liquid chromatography coupled with evaporative light scattering detection (HPLC‐ELSD) for the simultaneous determination of four major triterpenoid saponins, including Aralia‐saponin IV, Aralia‐saponin VI, 3‐O‐β‐d‐ glucopyranosyl‐(1 → 3)‐β‐d‐glucopyranosyl‐(1 → 3)‐β‐d‐glucopyranosyl oleanolic acid 28‐O‐β‐d‐glucopyranoside (Aralia‐saponin TTP)and Aralia‐saponin V.MethodologyThe separation was carried out on a Dikma Diamonsil C18 column (4.6 mm × 250 mm, 5 μm) efficiently with gradient elution consisting of acetonitrile and water.ResultsAll calibration curves showed good linear regression (R2 > 0.9996) within the ranges of tested concentrations. This validated method was applied to determine the contents of the four major triterpenoid saponins in 53 samples from different regions of northeast China. Hierarchical clustering analysis was first used to classify and differentiate Aralia elata leaves.ConclusionThe method developed was successfully applied to analyse four major triterpenoid saponins in Aralia elata leaves which is helpful for quality control of the herb. Copyright © 2017 John Wiley & Sons, Ltd.
Improving the curing process and thermal stability of phthalonitrile resin via novel mixed curing agents
Authors: Wu Zuoqiang , Han Jianhua , Li Nan , Weng Zhihuan , Wang Jinyan , Jian Xigao 
Published: January 2017

AbstractHigh curing temperature (including post‐curing temperature) and long curing time of phthalonitrile resins make them thermally stable but difficult to process. In this paper, novel mixed curing agents (CuCl/4,4′‐diaminodiphenylsulfone (DDS) and ZnCl2/DDS) were firstly designed for solving these problems. Bisphenol‐based phthalonitrile monomer (BP‐Ph; melting point: 228–235 °C) was synthesized and used as the curing precursor. Differential scanning calorimetry results indicated that BP‐Ph cured with CuCl/DDS and ZnCl2/DDS exhibited curing temperatures close to the melting point of BP‐Ph with curing ending temperatures of 225.4 and 287.1 °C, respectively. Rheologic investigations demonstrated obvious curing reactions of BP‐Ph occurred with the mixed curing agents at 220 °C. Thermogravimetric analysis showed that BP‐Ph cured by CuCl/DDS or ZnCl2/DDS maintained 95% mass at 573 or 546 °C, respectively, at a post‐curing temperature of 350 °C for 2 h. Reasonable long‐term thermo‐oxidative stability was also demonstrated. When the post‐curing temperature decreased to 290 °C, char yield at 800 °C of BP‐Ph cured by CuCl/DDS was 77.0%, suggesting the curing procedure can be milder when using mixed curing agents. © 2017 Society of Chemical Industry
Substituent effect on structure, stability, and aromaticity of novel BnNmC20–(n+m) heterofullerenes
Authors: Koohi Maryam , Soleimani Amiri Somayeh , Haerizade Bibi Narjes 
Published: January 2017

AbstractWe are focusing our calculations on the structural stabilities and electronic properties of 26 novel BnNmC20–(n+m) heterofullerenes, with n, m = 1 − 5, at B3LYP/6‐311++G** and B3LYP/AUG‐cc‐pVTZ levels of theory. Vibrational frequency calculations on C20 and its analogues show that except B2N2C16 (1) and B2N2C16 (2), all other heterofullerenes are true minima. The heats of atomization energies, binding energy, band gaps (ΔEHOMO‐LUMO), aromaticity, nucleus‐independent chemical shifts, thermodynamic stability, kinetic stability against electronic excitation, binding energy as a stability criterion of different configurations, geometrical parameters, conformational structures, conductivity, charge transfer, and possibility for hydrogen storage of these heterofullerenes strongly depend on their number of heteroatoms, topology, filling patterns, and locations as well as “B‐site and N‐site attachments.” B5N5C10 contains 5 alternating boron and nitrogen atoms in the equatorial position. It is predicted to be thermodynamically and kinetically the most stable against electron excites. Thus, it is energetically favorable and its electronic properties as well as stabilities make it perhaps a good candidate for an experimental investigation and testing verification.
Wideband spectrum compressive sensing for frequency availability in LEO‐based mobile satellite systems
Authors: Li Feilong , Li Guangxia , Li Zhiqiang , Wang Yulin , Lu Chao 
Published: January 2017

SummaryAvailability of L/S frequency band is a critical requirement for global communication provided by a constellation of low Earth orbit satellites. This paper investigates the issue of low Earth orbit mobile satellite system frequency availability, where wideband compressed signal detection approach is utilized to obtain active user subbands and their locations which should be avoided during frequency allocation. Compressed sensing can be achieved by exploiting the sparsity of wideband signal spectrum, whose useful frequency support occupies only a small portion of the entirely wide spectrum. An estimate of the signal spectrum can be obtained by using reconstruction algorithms. We define two novel wideband spectrum compressed sensing methods based on discrete cosine transform and Walsh–Hadamard transform, briefly named DCT‐WSCS and WHT‐WSCS, which significantly improve the performance of spectrum recovery and signal detection compared with conventional discrete Fourier transform‐based compressed spectrum sensing method. Furthermore, with the help of inter‐satellite links, the scheme of multiple satellites cooperatively sensing with a final decision according to OR and MAJ fusion rules is proposed, which can bring diversity gains. Finally, in‐depth numerical simulations under a particular scenario demonstrate the performance of the proposed scheme in the aspect of signal reconstruction precision, detection probability, and processing time. Copyright © 2017 John Wiley & Sons, Ltd.
Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study
Authors: Saka Hideo , Kitagawa Chiyoe , Kogure Yoshihito , Takahashi Yasuo , Fujikawa Koshi , Sagawa Tamotsu , Iwasa Satoru , Takahashi Naoki , Fukao Taro , Tchinou Catherine , Landers Dónal , Yamada Yasuhide 
Published: January 2017

SummaryBackground AZD4547 is a potent, oral, highly selective fibroblast growth factor receptor (FGFR) inhibitor in clinical development for treating tumours with a range of FGFR aberrations, including FGFR mutations, amplifications and fusions. Methods This open-label, Phase I, multicentre study (NCT01213160) evaluated the safety, pharmacokinetics, and preliminary antitumour efficacy (RECIST v1.1) of AZD4547 monotherapy in Japanese patients with advanced solid tumours. Part A was a dose-escalation part; Part B was a dose-expansion part in patients with FGFR-amplified tumours, confirmed by fluorescence in situ hybridization. Results Thirty patients enrolled in Part A (dose range: 40 mg twice daily [bid] to 120 mg bid; 160 mg once daily [qd]), four in Part B (80 mg bid). No dose-limiting toxicities were observed and maximum tolerated dose was not determined. Most common adverse events (AEs; any grade) were: dysgeusia (50% of patients); stomatitis (41%); diarrhoea (38%); hyperphosphataemia (38%); dry mouth (35%). Common grade ≥3 AEs were nausea (12% of patients) and neutropenia (9%). No complete or partial responses were observed: 21/30 patients had stable disease ≥4 weeks in Part A, and 1/4 patients had stable disease ≥10 weeks in Part B. Following single and multiple dosing, absorption rate appeared moderate; peak plasma concentrations generally occurred 3–4 h post-dose, then declined biphasically with terminal half-life ~30 h. Steady state was reached by day 8. Compared with single dosing, plasma concentrations were, on average, 2.4- and 3.3- to 5.4-fold higher after qd and bid dosing, respectively. Conclusions AZD4547 was well tolerated in Japanese patients, with best response of stable disease ≥4 weeks.
Doing for others: Youth's contributing behaviors and psychological engagement in youth‐adult partnerships
Authors: Ramey Heather L. , Lawford Heather L. , Rose‐Krasnor Linda 
Published: January 2017

ABSTRACTYouth contributions to others (e.g., volunteering) have been connected to indicators of successful development, including self‐esteem, optimism, social support, and identity development. Youth‐adult partnerships, which involve youth and adults working together towards a shared goal in activity settings, such as youth‐serving agencies or recreation organizations, provide a unique opportunity for examining youth contributions. We examined associations between measures of youth's participation in youth‐adult partnerships (psychological engagement and degree of partnering) in activity settings and youth contributing behaviors, in two Canadian samples: (a) community‐involved youth (N = 153, mean age = 17.1 years, 65% female) and (b) undergraduates (N = 128, mean age = 20.1 years, 92.2% female). We found that degree of partnering and psychological engagement were related to each other yet independently predicted contributing behaviors. Our findings suggest that youth‐adult partnerships might be one potentially rich context for the promotion of youth's contributions to others.
Reliability and Validity of the Activity Participation Assessment for School-age Children in Korea
Authors: Kim Se-Yun , Yoo Eun-Young , Jung Min-Ye , Park Soo-Hyun , Lee Jae-Shin , Ji-Yeon Lee 
Published: January 2017

Objective This pilot study examined the internal consistency, test—retest reliability, construct validity, and discriminant validity of the Activity Participation Assessment (APA) for school-age children in Korea. Methods The construct validity of the APA was first established by factor analysis on the response of 134 nondisabled children. Internal consistency was evaluated for each of the factors. A test—retest study was conducted on 22 nondisabled children. Discriminant validity was established by comparing the participation of 56 nondisabled children and 56 children with intellectual disabilities and examining sex differences of 61 boys and 61 girls. Results Analysis of the APA revealed five factors, which were labeled as instrumental activities of daily living (IADL), sports and outdoor activities, hobbies and school activities, social activities, and personal care. The factors showed acceptable levels of internal reliability (Cronbach's alpha = .63–.89). The intraclass correlation coefficient (ICC) for the five factors were all in the good range (ICC = .86–.92). We found statistically significant difference between nondisabled children and children with intellectual disabilities in five factors. We also found that girls participated in significantly more IADL, hobbies and school activities, and social activities. However, boys participated in significantly more sports and outdoor activities. Conclusion The APA shows good internal reliability, test—retest reliability, discriminant validity, and construct validity. However, evidence of psychometric properties was limited by a small sample size. Psychometric properties such as interrater reliability as well as concurrent validity and construct validity need to be tested using a larger sample size with representative demographics.
Pain and major depressive disorder: Associations with cognitive impairment as measured by the THINC-integrated tool (THINC-it)
Authors: Cha Danielle S. , Carmona Nicole E. , Mansur Rodrigo B. , Lee Yena , Park Hyun Jung , Rodrigues Nelson B. , Subramaniapillai Mehala , Rosenblat Joshua D. , Pan Zihang , Lee Jae Hon , Lee JungGoo , Almatham Fahad , Alageel Asem , Shekotikhina Margarita , Zhou Aileen J. , Rong Carola , Harrison John , McIntyre Roger S. 
Published: January 2017

Abstract

Objectives
To examine the role of pain on cognitive function in adults with major depressive disorder (MDD).

Methods
Adults (18–65) with a Diagnostic and Statistical Manual – Fifth Edition (DSM-5)-defined diagnosis of MDD experiencing a current major depressive episode (MDE) were enrolled (nMDD = 100). All subjects with MDD were matched in age, sex, and years of education to healthy controls (HC) (nHC = 100) for comparison. Cognitive function was assessed using the recently validated THINC-integrated tool (THINC-it), which comprises variants of the choice reaction time (i.e., THINC-it: Spotter), One-Back (i.e., THINC-it: Symbol Check), Digit Symbol Substitution Test (i.e., THINC-it: Codebreaker), Trail Making Test – Part B (i.e., THINC-it: Trails), as well as the Perceived Deficits Questionnaire for Depression – 5-item (i.e., THINC-it: PDQ-5-D). A global index of objective cognitive function was computed using objective measures from the THINC-it, while self-rated cognitive deficits were measured using the PDQ-5-D. Pain was measured using a Visual Analogue Scale (VAS). Regression analyses evaluated the role of pain in predicting objective and subjective cognitive function.

Results
A significant between-group differences on the VAS was observed (p < 0.001), with individuals with MDD reporting higher pain severity as evidenced by higher scores on the VAS than HC. Significant interaction effects were observed between self -rated cognitive deficits and pain ratings (p < 0.001) on objective cognitive performance (after adjusting for MADRS total score), suggesting that pain moderates the association between self-rated and objective cognitive function.

Conclusions
Results indicated that pain is associated with increased self-rated and objective cognitive deficits in adults with MDD.

Implications
The study herein provides preliminary evidence demonstrating that adults with MDD reporting pain symptomatology and poorer subjective cognitive function is predictive of poorer objective cognitive performance. THINC-it is capable of detecting cognitive dysfunction amongst adults with MDD and pain.