bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reactivity Differences of Sc3N@C2n (2n: 68 and 80). Synthesis of the First Methanofullerene Derivatives of Sc3N@D5h—C80.
Authors: Ceron Maira R. , Izquierdo Marta , Alegret Nuria , Valdez Juan A. , Rodriguez‐Fortea Antonio , Olmstead Marilyn M. , Balch Alan L. , Poblet Josep M. , Echegoyen Luis 
Published: February 2016

AbstractUsing a purification method introduced earlier based on redox properties, it is possible to isolate Sc3N@Ih‐C80 and Sc3N@D3h‐C78 and a mixture of Sc3N@D5h‐C80 and Sc3N@D3‐C68.
ChemInform Abstract: A Three‐Component Reaction for the Efficient Construction of the 2′,11b′‐Dihydrospiro[indoline‐3,1′‐pyrido[2,1‐a]isoquinoline] Skeleton.
Authors: Sun Jing , Sun Yan , Gong Hui , Yan Chao‐Guo 
Published: February 2016

Abstract16 Title compounds of type (IV)/(V) are prepared by a three‐component one‐pot reaction.
ChemInform Abstract: An Efficient Synthesis of Novel Dispiro Derivatives via Three‐Component 1,3‐Dipolar Cycloaddition Reactions under Ultrasound Irradiation.
Authors: Shi Chunling , Zhou Jun 
Published: February 2016

AbstractThe title reaction of acenaphthenequinone, thiazolidine‐4‐carboxylic acid and (Z)‐5‐benzylidene‐2‐thioxothiaazolidin‐4‐one or (Z)‐5‐benzylidenethiaazolidin‐2,4‐dione efficiently provides a series of new spiro compounds.
ChemInform Abstract: Asymmetric Alkylation of 3‐Substituted Benzofuran‐2(3H)‐ones.
Authors: Luo Chao , Zhang Enge , Li Xin 
Published: February 2016

AbstractAlkylation of benzofuranones (I) with alcohols in the presence of a chiral biscinchona catalyst affords the 3‐alkylated product with good enantioselectivities up to 83% e.e.
ChemInform Abstract: One‐Pot Relay Gold(I) and Broensted Acid Catalysis: Cyclopenta[b]annulation of Indoles via Hydroamination/Nazarov‐Type Cyclization Cascade of Enynols.
Authors: Dhiman Seema , Ramasastry S. S. V. 
Published: February 2016

AbstractThe utility of the method is demonstrated by its application in the synthesis of complex natural product‐derived structures and indole steroidal conjugates.
ChemInform Abstract: A New Water‐Soluble Ligand for Efficient Copper‐Catalyzed Huisgen Cycloaddition of Aliphatic Azides and Alkynes.
Authors: Szafranski Przemyslaw W. , Kasza Patryk , Cegla Marek T. 
Published: February 2016

AbstractTriazole (III) is prepared and successfully employed as novel water‐soluble ligand for the copper‐catalyzed cycloaddition reaction of azides and alkynes.
ChemInform Abstract: Nano‐Copper Catalyzed Three‐Component Tandem Cycloaddition and N‐Alkylation Reaction from Aminophenylacetylenes, Sodium Azide and Alkyl Halides.
Authors: Du Zhengyin , Gang Fangli , Dong Taosheng , Xu Guangli , Fu Ying 
Published: February 2016

AbstractThe reaction tolerates aliphatic halides and benzylic halides, with bromides providing higher yields than chlorides.
ChemInform Abstract: One‐Pot Domino Synthesis of 3‐Amino‐1,2‐dihydroisoquinolines.
Authors: Hamri W. , Shyshkina O. O. , Tarasiuk T. M. , Volovnenko T. A. , Mesbah K. , Rhouati S. , Volovenko Y. M. , Medviediev V. V. , Shishkin O. V. 
Published: February 2016

Abstract9 Title compounds of type (III) are prepared.
ChemInform Abstract: Biopolymeric Alginic Acid: An Efficient Recyclable Green Catalyst for the Friedel—Crafts Reaction of Indoles with Isoquinoline‐1,3,4‐triones in Water.
Authors: Srivastava Anvita , Yadav Anubha , Samanta Sampak 
Published: February 2016

AbstractThe operationally simple procedures allow the selective formation of 4‐indolylisoquinoline derivatives as well as symmetrical and unsymmetrical 4,4‐diindolyl substituted products (IV).
ChemInform Abstract: Two New Cucurbitane Triterpenoids from Immature Fruits of Momordica charantia
Authors: Li Zhen‐Jie , Chen Jian‐Chao , Deng Yuan‐Yuan , Song Na‐Li , Yu Mu‐Yuan , Zhou Lin , Qiu Ming‐Hua 
Published: February 2016

Abstractisolation and characterization of kuguacin X (I) and kuguaglycoside I (II)
ChemInform Abstract: Antimicrobial and Antiinflammatory Compounds from a Marine Fungus Pleosporales sp.
Authors: Chen Chao Jun , Zhou Yi Qin , Liu Xian Xian , Zhang Wen Jing , Hu Sha Sha , Lin Li Ping , Huo Guang Ming , Jiao Rui Hua , Tan Ren Xiang , Ge Hui Ming 
Published: February 2016

AbstractPleosporallins A—G (I)—(VII) are isolated from the title fungus.
The influence of different anticoagulants and time‐delayed sample processing and measurements on human monocyte subset and monocyte‐platelet aggregate analyses
Authors: Ji Wen‐Jie , Lu Rui‐Yi , Liu Jun‐Xiang , Ma Yong‐Qiang , Zeng Shan , Shi Rui , Zhao Ji‐Hong , Chen Shao‐Bo , Zhou Xin , Li Yu‐Ming 
Published: February 2016

BackgroundMeasuring human monocyte subsets (CD14++CD16−, CD14++CD16+, and CD14 + CD16++) and subset‐specific monocyte‐platelet aggregates (MPA) is vulnerable to analytical bias due to unavailability of a standardized methodology. We aimed to address this issue by focusing on the impacts of time‐delayed sample processing and measurement between two commonly used anticoagulants.MethodsEthylenediaminetetraacetic acid (EDTA)‐ and sodium citrate (SC)‐anticoagulated blood samples from 12 healthy donors were subject to either delayed (2‐h delay, kept at 4°C) or immediate processing (without fixation) before four‐color flow cytometry (FCM) analysis.ResultsIn SC‐anticoagulated samples, a 2‐h delay in sample processing contributed to a significant decrease in CD14++CD16− monocyte percent and a reciprocal increase in CD14++CD16+ monocytes, as well as increases in all three subset‐specific MPA. Similar slight, but non‐significant changes were observed in EDTA‐treated samples. In samples processed immediately and stored at 4°C, delayed measurement at 0, 1, 3, and 5 h after processing led to a time‐dependent decrease in CD14++CD16− monocyte percent and a reciprocal increase in CD14++CD16+ subset in SC‐treated, but not in EDTA‐treated, samples. Moreover, a time‐dependent increase in all three subset‐specific MPA was observed in SC‐treated samples, which, to a lesser extent, was only observed in CD14++CD16+ MPA in EDTA‐treated samples after storage at 4°C for 3–5 h after processing.ConclusionsWe recommend EDTA for anticoagulation. Additionally, sample should be stored at 4°C and processing and measuring should be performed within 2 h after harvest and 3 h after processing, respectively. © 2016 International Clinical Cytometry Society
Susceptibility of metallic magnesium implants to bacterial biofilm infections
Authors: Rahim Muhammad Imran , Rohde Manfred , Rais Bushra , Seitz Jan‐Marten , Mueller Peter P. 
Published: February 2016

AbstractMagnesium alloys have promising mechanical and biological properties as biodegradable medical implant materials for temporary applications during bone healing or as vascular stents. Whereas conventional implants are prone to colonization by treatment resistant microbial biofilms in which bacteria are embedded in a protective matrix, magnesium alloys have been reported to act antibacterial in vitro. To permit a basic assessment of antibacterial properties of implant materials in vivo an economic but robust animal model was established. Subcutaneous magnesium implants were inoculated with bacteria in a mouse model. Contrary to the expectations, bacterial activity was enhanced and prolonged in the presence of magnesium implants. Systemic antibiotic treatments were remarkably ineffective, which is a typical property of bacterial biofilms. Biofilm formation was further supported by electron microscopic analyses that revealed highly dense bacterial populations and evidence for the presence of extracellular matrix material. Bacterial agglomerates could be detected not only on the implant surface but also at a limited distance in the peri‐implant tissue. Therefore, precautions may be necessary to minimize risks of metallic magnesium‐containing implants in prospective clinical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1489–1499, 2016.
Matrix metalloproteinase‐11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas
Authors: Li Wei‐Ming , Wei Yu‐Ching , Huang Chun‐Nung , Ke Hung‐Lung , Li Ching‐Chia , Yeh Hsin‐Chih , Chang Lin‐Li , Huang Chun‐Hsiung , Li Chien‐Feng , Wu Wen‐Jeng 
Published: February 2016

Background and ObjectivesUrothelial carcinomas (UC) of urinary bladder (UB) and upper urinary tract (UT) are heterogeneous diseases with high morbidity and mortality. We looked for genes with metalloendopeptidase activity in a published UBUC transcriptomic database (GSE31684):MMP‐11 was the most significant, showing stepwise up‐regulation. We analyzed MMP‐11 expression and association with clinicopathologic factors and survival in our well‐characterized cohort of UCs.MethodsWe determined MMP‐11 expression in 295 UBUCs and 340 UTUCs with immunohistochemistry, evaluated by H‐score. In a retrospective study, MMP‐11 expression was correlated with clinicopathologic features and with disease‐specific survival (DSS) and metastasis‐free survival (MeFS). The statistical significance was evaluated with univariate and multivariate analyses.ResultsHigh MMP‐11 expression was significantly associated with advanced pT status, nodal metastasis, high histological grade, vascular and perineural invasion, and frequent mitoses. In multivariate Cox regression analyses, which adjusted for standard clinicopathologic characteristics, MMP‐11 expression was independently associated with cancer‐specific mortality (hazard ratio [HR] in UTUC:3.027, P = 0.005; in UBUC: 2.631, P = 0.010) and with metastasis development (HR in UTUC:2.261, P = 0.018; in UBUC:1.801, P = 0.026).ConclusionsMMP‐11 overexpression is associated with aggressive tumor phenotype and unfavorable clinical outcome in UTUC and UBUC, suggesting it may serve as a novel prognostic and therapeutic target. J. Surg. Oncol. 2016;113:700–707. © 2016 Wiley Periodicals, Inc.
Identification and functional analysis of a bacteriocin, pyocin S6, with ribonuclease activity from a Pseudomonas aeruginosa cystic fibrosis clinical isolate
Authors: Dingemans Jozef , Ghequire Maarten G. K. , Craggs Michael , De Mot René , Cornelis Pierre 
Published: February 2016

AbstractS‐type pyocins are bacteriocins produced by Pseudomonas aeruginosa isolates to antagonize or kill other strains of the same species. They have a modular organization comprising a receptor‐binding domain recognizing a surface constituent of the target bacterium, a domain for translocation through the periplasm, and a killing or toxic domain with DNase, tRNase, or pore‐forming activity. Pyocins S2, S3, S4, and S5 recognize TonB‐dependent ferri‐siderophore receptors in the outer membrane. We here describe a new nuclease bacteriocin, pyocin S6, encoded in the genome of a P. aeruginosa cystic fibrosis (CF) clinical isolate, CF_PA39. Similarly to pyocins S1 and S2, the S6 toxin–immunity gene tandem was recruited to the genomic region encoding exotoxin A. The pyocin S6 receptor‐binding and translocation domains are identical to those of pyocin S1, whereas the killing domain is similar to the 16S ribonuclease domain of Escherichia coli colicin E3. The cytotoxic activity was abolished in pyocin S6 forms with a mutation in the colicin E3‐equivalent catalytic motif. The CF_PA39 S6 immunity gene displays a higher expression level than the gene encoding the killing protein, the latter being only detected when bacteria are grown under iron‐limiting conditions. In the S1‐pyocinogenic strain P. aeruginosa ATCC 25324 and pyocin S2 producer P. aeruginosa PAO1, a remnant of the pyocin S6 killing domain and an intact S6‐type immunity gene are located downstream of their respective pyocin operons. Strain PAO1 is insensitive for pyocin S6, and its S6‐type immunity gene provides protection against pyocin S6 activity. Purified pyocin S6 inhibits one‐fifth of 110 P. aeruginosa CF clinical isolates tested, showing clearer inhibition zones when the target cells are grown under iron limitation. In this panel, about half of the CF clinical isolates were found to host the S6 genes. The pyocin S6 locus is also present in the genome of some non‐CF clinical isolates.
Validation of conversion between mini–mental state examination and montreal cognitive assessment
Authors: Lawton Michael , Kasten Meike , May Margaret T. , Mollenhauer Brit , Schaumburg Martina , Liepelt‐Scarfone Inga , Maetzler Walter , Vollstedt Eva‐Juliane , Hu Michele T.M. , Berg Daniela , Ben‐Shlomo Yoav 
Published: February 2016

ABSTRACTIntroductionHarmonizing data across cohorts is important for validating findings or combining data in meta‐analyses. We replicate and validate a previous conversion of MoCA to MMSE in PD.MethodsWe used five studies with 1,161 PD individuals and 2,091 observations measured with both the MoCA and MMSE. We compared a previously published conversion table using equipercentile equating with log‐linear smoothing to our internally derived scores.ResultsBoth conversions found good agreement within and across the studies when comparing true and converted MMSE (mean difference: 0.05; standard deviation: 1.84; median difference: 0; interquartile range: –1 to 1, using internal conversion).ConclusionsThese results show that one can get a reliable and valid conversion between two commonly used measures of cognition in PD studies. These approaches need to be applied to other scales and domains to enable large‐scale collaborative analyses across multiple PD cohorts. © 2016 International Parkinson and Movement Disorder Society
FDM and FEM solutions to linear dynamics of porous media: stabilised, monolithic and fractional schemes
Authors: Zhang Yunpeng , Pedroso Dorival M. , Li Ling 
Published: February 2016

SummaryA number of methods have been developed for solving the dynamics of saturated porous media. However, most solutions are based on the finite element method, and only a few employ finite differences (FDM). One problem with the FDM is the difficulty in fulfilling the inf‐sup (Ladyženskaja‐Babuška‐Brezzi) condition. This paper explores solutions with the FDM, including the development of new schemes aiming at stabilised formulations. The efficiency, accuracy and stability of several FDM and finite element method algorithms are thoroughly investigated as well. A combination of primary variables from the theory of porous media is considered, including the so‐called up and uvp formulations. Six numerical schemes are produced and quantitatively studied. Simulations of 1D and 2D wave propagation problems are performed in order to reveal the advantages and drawbacks of all schemes. Copyright © 2016 John Wiley & Sons, Ltd.
THE CONTRIBUTION OF SCHOOL COUNSELORS’ SELF‐EFFICACY TO THEIR PROGRAMMATIC SERVICE DELIVERY
Authors: Mullen Patrick R. , Lambie Glenn W. 
Published: February 2016

Self‐efficacy pertains to individuals’ belief about their capability to accomplish a task; consequently, school counselors’ positive self‐efficacy is a theoretically based prerequisite for their facilitation of school‐based interventions. In addition, school counselor‐led interventions and comprehensive, developmental guidance programs benefit students’ personal social, academic, and career development. Therefore, this investigation examined the contribution of practicing school counselors’ (N = 693) self‐efficacy in relation to the frequency of their programmatic service delivery. The findings indicate that participants’ self‐efficacy scores contributed to the frequency of their programmatic service delivery (48% of the variance explained). Implications for school counselors, supervisors, and educational researchers are discussed.
Formation of icosahedral nanowires
Authors: Fujita Naoya , Kurokawa Shu , Sakai Akira 
Published: February 2016

AbstractAn icosahedral nanowire (INW) is a one‐dimensional structure where a single atom and a five‐membered ring are alternating to form a stacking. The segment of this stacking forms an icosahedron and constitutes the unit cell of an INW. In molecular dynamics (MD) simulations of stretching of metal nanowires (NWs), INWs are frequently formed at their deformation necks. Previous simulations found that the formation of INWs is more favored for thin NWs than thick NWs. To closely investigate this size dependence of INW formation, we have carried out stretching simulations of Mg NWs and examined the creation of icosahedral arrangement of atoms at their deformation necks. Our results show that thin NWs tend to produce slender necks, the atoms of which first become disordered and then rearrange themselves into an icosahedral arrangement. Thick nanowires rarely form such slender necks and this accounts for their low yield of INWs. We have also investigated a continuous and bond‐conserving process that converts the HCP arrangement of atoms into an icosahedral one. We found that the nearest‐neighbor bonds are not conserved and only a small fraction of nearest‐neighbor atoms in an icosahedral unit cell are initially nearest neighbors.
Improved removal of volatile organic compounds for laser‐based spectroscopy of water isotopes
Authors: Chang Elliot , Wolf Adam , Gerlein‐Safdi Cynthia , Caylor Kelly K. 
Published: February 2016

RationaleVolatile organic compounds (VOCs) such as methanol and ethanol in water extracted from plants cause spectral interference in isotope ratio infrared spectroscopy (IRIS). This contamination degrades the accuracy of measurements, limiting the use of IRIS. In response, this study presents a new decontamination method of VOCs for enhanced IRIS measurements.MethodsThe isotopic compositions of water from laboratory‐made and field‐collected plant samples pre‐ and post‐treatment were analyzed using IRIS. Traditional treatment methods of activated charcoal and commercial pre‐combustion systems (MCM) were compared with our new treatment method that implements solid‐phase extraction (SPE). The absolute concentrations of contaminants pre‐ and post‐treatment were determined using 1H and 13C nuclear magnetic resonance to assess the effectiveness of the different treatments.ResultsSPE removes an average of 86.7% and 78.8% ethanol and methanol, respectively, significantly reducing spectral interference. SPE reduces errors to within instrumental noise for both ethanol and methanol at concentrations found in nature (<3.0% and 0.08%, respectively). Activated charcoal minimally affected alcohol concentrations. MCM significantly worsened ethanol‐contaminated water isotope measurements by producing primary alcohol oxidation products such as formic acid, another compound that interferes with IRIS absorption.ConclusionsSPE is an effective, low‐cost method for eliminating errors in ethanol‐contaminated samples. For samples where methanol is prevalent, combining SPE and MCM is more effective than the use of SPE alone. Hence, SPE treatment alone or in conjunction with MCM is recommended as an effective pre‐analysis purification method for water extracted from plants. Copyright © 2016 John Wiley & Sons, Ltd.
EPOinduces changes in synaptic transmission and plasticity in the dentate gyrus of rats
Authors: Almaguer‐Melian William , Mercerón‐Martínez Daymara , Delgado‐Ocaña Susana , Pavón‐Fuentes Nancy , Ledón Nuris , Bergado Jorge A. 
Published: February 2016

ABSTRACTErythropoietin has shown wide physiological effects on the central nervous system in animal models of disease, and in healthy animals. We have recently shown that systemic EPO administration 15 min, but not 5 h, after daily training in a water maze is able to induce the recovery of spatial memory in fimbria‐fornix chronic‐lesioned animals, suggesting that acute EPO triggers mechanisms which can modulate the active neural plasticity mechanism involved in spatial memory acquisition in lesioned animals. Additionally, this EPO effect is accompanied by the up‐regulation of plasticity‐related early genes. More remarkably, this time‐dependent effects on learning recovery could signify that EPO in nerve system modulate specific living‐cellular processes. In the present article, we focus on the question if EPO could modulate the induction of long‐term synaptic plasticity like LTP and LTD, which presumably could support our previous published data. Our results show that acute EPO peripheral administration 15 min before the induction of synaptic plasticity is able to increase the magnitude of the LTP (more prominent in PSA than fEPSP‐Slope) to facilitate the induction of LTD, and to protect LTP from depotentiation. These findings showing that EPO modulates in vivo synaptic plasticity sustain the assumption that EPO can act not only as a neuroprotective substance, but is also able to modulate transient neural plasticity mechanisms and therefore to promote the recovery of nerve function after an established chronic brain lesion. According to these results, EPO could be use as a molecular tool for neurorestaurative treatments.Synapse 70:240–252, 2016. © 2016 Wiley Periodicals, Inc.
Active-Transient Liquid Phase (A-TLP) Bonding of Pure Aluminum Matrix Composite Reinforced with Short Alumina Fiber Using Al-12Si-xTi Foils as Active Interlayer
Authors: Zhang Guifeng , Su Wei , Suzumura Akio 
Published: February 2016

Abstract
To optimize both the interlayer composition design route and pressure for joining aluminum matrix composite reinforced with short alumina fiber (as-cast 30 vol pct Al2O3sf/Al), traditional transient liquid phase (TLP) bonding using Al-12Si and Cu interlayer and active-TLP (A-TLP) bonding using an active Ti-containing interlayer (Al-12Si-xTi, x = 0.1, 0.5, and 1 wt pct) under the same condition [883 K (610 °C) × 30 minutes × 1 or 0.015 MPa in flowing argon] were compared in terms of interfacial wettability, bond seam microstructure, shear strength, and fracture path. It was found that not only the Ti content but also the pressure are critical factors affecting interfacial wettability and bond seam microstructure. The improvement in wettability by adding Ti as an active element were confirmed by reduction of expulsion of liquid interlayer, elimination of interfacial gap, higher shear strength and favorable fracture path (partially through bond seam and the composite). Because of the incubation period for wetting, reducing the pressure after melting of the interlayer could further increase joint shear strength by thickening the remaining bond seam of solid-solution matrix and decreasing fraction of the in situ newly formed Al-Si-Ti IMC phase (short bar shape) within the bond seam. The maximum shear strength of 88.6 MPa (99 pct of the as-cast composite) was obtained by adding trace Ti content (0.5 Ti wt pct) addition and using low pressure (0.015 MPa). The results showed that suitable combination of Ti content and pressure pattern is required for improving both wettability and bond seam microstructure.
Cognitive autonomy among adolescents with and without hearing loss: Associations with perceived social support
Authors: Michael Rinat , Attias Joseph 
Published: February 2016

ABSTRACTCognitive autonomy is a skill which may help adolescents prepare for important decisions in adulthood. The current study examined the associations between cognitive autonomy and perceived social support among adolescents with and without hearing loss. Participants were 177 students: 55 were deaf and hard of hearing (dhh) and 122 were hearing. They completed the Cognitive Autonomy and Self‐Evaluation Inventory, the Multidimensional Scale of Perceived Social Support, and a demographic questionnaire. Significant positive correlations were found between some of the cognitive autonomy variables and some of the perceived social support variables. However, among the dhh group, they were fewer and weaker. Family support was found to be a significant predictor of three out of the five cognitive autonomy variables. In addition, significant differences were found between the dhh and hearing participants in some of the cognitive autonomy variables, but not in perceived social support. Implications for theory and practice are discussed.