bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selling winners, buying losers: Mental decision rules of individual investors on their holdings
Authors: Leal Cristiana Cerqueira , Loureiro Gilberto , Armada Manuel J. Rocha 
Published: August 2017

AbstractWe extend the study of the disposition effect − the preference for selling (holding) current winning (losing) stocks − by adding a new element to this decision process: the investors’ preference to purchase additional units of the current losing stocks. Using a unique database, we find that individual investors prefer to sell their winning stocks and, simultaneously, hold and increase their exposure to the losing ones. The additional purchase is pervasive across investors, but stronger for less sophisticated investors. Our evidence suggests that reference prices, prior stock returns, stock visibility, and investor performance and sophistication are determinants of investors’ trading behavior.
The impact of age and sex on the reporting of cough and angioedema with renin–angiotensin system inhibitors: a case/noncase study in VigiBase
Authors: Alharbi Fawaz F. , Kholod Anzhelika A.V. , Souverein Patrick C. , Meyboom Ronald H. , de Groot Mark C.H. , de Boer Anthonius , Klungel Olaf H. 
Published: August 2017

AbstractThe purpose of this study was to assess the impact of age and sex on the reporting of cough and angioedema related to renin–angiotensin system (RAS) inhibitors. A case/noncase study was performed in VigiBase. Two case groups were identified, reports of cough and reports of angioedema, and noncases were all reports of all other adverse events. Logistic regression analysis was used to assess the association between reporting of cough and angioedema with each class of RAS inhibitors stratified by age/sex and to control for confounding. The reporting of cough with angiotensin‐converting enzyme (ACE) inhibitors was significantly higher in women than in men [adjusted reporting odds ratio (ROR): 44.0, 95% CI (43.2–44.8) for women vs. 29.2, 95% CI (28.5–29.9) for men]. There was no difference in reporting of cough linked to angiotensin receptor blockers (ARBs) and aliskiren between men and women. In contrast, the reporting of angioedema with ACE inhibitors and ARBs was significantly higher in men than in women, but for aliskiren, women had a significantly higher ROR than men [adjusted ROR: 5.20, 95% CI (4.18–6.46) for women vs. 3.04, 95% CI (2.30–4.02) for men]. The reporting of cough with ACE inhibitors was increased with age until reaching a plateau at middle adulthood (40–59 years) and the reporting of angioedema with ACE inhibitors was increased with age until elderly (60–79 years). Age had only a slight effect on the reporting of cough and angioedema with ARBs and aliskiren. Both age and sex have substantial effects on the reporting of cough and angioedema with RAS inhibitors and in particular ACE inhibitors. Further study is needed to determine whether these differences mainly express different adverse drug reaction risks in subgroups or also can be explained by factors influencing reporting.
Behavioural changes of Atlantic cod (Gadus morhua) after marine boulder reef restoration: Implications for coastal habitat management and Natura 2000 areas
Authors: Kristensen L. D. , Støttrup J. G. , Svendsen J. C. , Stenberg C. , Højbjerg Hansen O. K. , Grønkjær P. 
Published: August 2017

AbstractWhile marine reefs are degraded globally, the responses of fish to marine reef restoration remain uncertain, particularly in temperate waters. This study measured the effect of marine boulder reef restoration on the behaviour of Atlantic cod, Gadus morhua L., in a Natura 2000 area using acoustic telemetry. Cod were tagged and released in the study area before and after the restoration and tracked continuously for six months. A larger fraction of the released fish remained in the study area after restoration (94%) than before (53%). Moreover, throughout the study period, cod spent significantly more hours per day and prolonged their residence time in the study area after the restoration. The study indicates that marine reefs subjected to boulder extraction can be restored and function as favourable cod habitats. Temperate marine boulder reef restoration represents a valuable management tool to improve habitats for temperate fish species.
Variation in characteristics among gizzard shad populations: The role of impoundment size and productivity
Authors: Michaletz P. H. 
Published: August 2017

AbstractPopulation characteristics of gizzard shad, Dorosoma cepedianum (Lesueur), an ecologically important fish species in Midwestern and southern USA impoundments, vary widely among water bodies. Impoundment productivity is known to influence population variables (e.g., recruitment, growth, mortality, size and age composition), but the role of impoundment morphometry (e.g., surface area, depth) is unknown. Differences in population characteristics of gizzard shad were compared between large and small impoundments across an impoundment–productivity gradient (indexed by total phosphorus [TP] concentration). Populations shifted from those comprised mostly of low abundances (indexed by catch per unit effort [CPUE], fish/hr of electric fishing) of long‐lived, large adults to those comprised of high abundances of short‐lived, small adults as TP increased. However, the trends in population variables across the TP gradient were less apparent in small impoundments than in large impoundments owing to considerable variation at a given TP level. Further analysis revealed that CPUE of gizzard shad was lowest in the smallest impoundments (<33 ha surface area) regardless of TP concentrations, probably because of more frequent winter kills. Overall, population characteristics were influenced by both density‐dependent effects and impoundment characteristics. Characteristics of gizzard shad were highly variable among populations, which have important consequences for ecosystem structure and function.
Multiple influences on participating in physical activity in older age: Developing a social ecological approach
Authors: Boulton Elisabeth R. , Horne Maria , Todd Chris 
Published: August 2017

AbstractBackgroundEvidence of the benefits of engaging in physical activity (PA) is strong, yet the number of older adults meeting the recommended 150 min/wk is low. Policy to increase uptake and adherence has focussed on the health benefits of PA, but may not be the most successful approach.ObjectiveThis qualitative study sought to ask older adults what the components of a successful intervention to promote PA would be, by asking active older adults what motivated them to be active and asking inactive older adults what might encourage them to change.Design, setting and participantsFocus groups and semi‐structured interviews were held with 60 community‐dwelling older adults, aged 50‐87 years. Framework analysis was used to analyse the data, and themes congruent with a social ecological model of behaviour change were developed.FindingsFive themes emerged that influenced PA engagement at multiple levels: individual; interpersonal; perceived environment; community or organizational; and policy. PA engagement was determined by attitude or health status for some participants, but for the majority, PA being enjoyable, sociable, affordable, accessible, flexible and seasonal were more important than the health benefits.Discussion and conclusionsA social ecological model is presented, highlighting the fact that both motivated and unmotivated older adults need to have a range of appropriately labelled, appealing and accessible activities to choose from when thinking about engaging in PA. Policymakers and practitioners need to ensure that their offers of activity sessions are easy to access and easy to remain involved in.
Tensile and fatigue behavior of oxide/oxide ceramic matrix composite with simulated foreign object damage in combustion environment
Authors: Singh Abhendra , Mall Shankar 
Published: August 2017

AbstractIn this study, oxide/oxide ceramic matrix composite test coupons were quasi‐statically indented and tested for tensile strength and fatigue life in a combustion environment. The combustion environment simulated the gas turbine engine environment in an aircraft. Two different dent sizes were created on two different sets of test coupons with a blunt conical indentor. During mechanical testing, the combustion flame simultaneously impinged on the dent region resulting in a maximum test coupon surface temperature of 1250 ± 50°C. For a life of 90 000 cycles, the fatigue limit in the combustion environment was 85% of the postindentation degraded tensile strength. Microscopy images of the failed test coupons showed damage modes of fiber fracture and matrix cracking at the dent site. The run‐out test coupons which did not fail within 90 000 cycles showed residual strength that was not significantly different from that of their virgin counterparts.
Population invariance properties of social and economic networks
Authors: Chun Youngsub , Hong Sunghoon , Koh Bong Chan 
Published: August 2017

AbstractThis paper investigates how a pairwise stable network changes upon the arrival of a new agent. Comparing the new networks obtained for the society after the arrival of a new agent with the initially pairwise stable network, we propose four different population invariance properties of a network: link invariance, distance invariance, connectedness invariance, and network invariance. We show that pairwise stability is incompatible with link invariance under certain assumptions on the allocation rule. However, if we consider specific models, positive results can be obtained. For instance, in the symmetric connections model, pairwise stability implies connectedness invariance.
Trade liberalization and forest transition
Authors: González‐Val Rafael , Pueyo Fernando 
Published: August 2017

AbstractWe develop a theoretical model that provides an additional explanation for the forest transition based on a trade liberalization scenario. We introduce a renewable natural resource (wood), used as an input by manufacturing firms, in a framework with economic geography foundations: transport costs affect the spatial distribution of firms. In a general equilibrium, the results reproduce the forest transition at a global scale: a decrease in transport costs has an initial negative effect on the worldwide stock of the natural resource, but this effect is offset over time as a consequence of industrial reallocation and eventually disappears in the long run.
Synergistic effects of high pressure processing and slightly acidic electrolysed water on the inactivation of Bacillus cereus spores
Authors: Wang Liping , Xia Qiang , Li Yunfei 
Published: August 2017

SummaryBacillus spores are concerns for their resistance to heat, high pressure processing (HPP), and disinfectants. We examined the effects of HPP and slightly acidic electrolysed water (SAEW) on inactivation of B. cereus spores. Spores' suspensions were prepared with 2‐(N‐morpholino) ethanesulfonic acid (MES) buffer or SAEW with available chlorine content (ACC) of 24, 35, 44 or 55 mg L−1, and then subjected to HPP. The individual effects of HPP or SAEW on spores were negligible (<1.0 log CFU mL−1). With factorial design and anova analysis, HPP + SAEW treatment was shown to have significantly positive effects on spores’ inactivation. The optimal conditions were 300 MPa HPP + SAEW with 44 mg L−1 ACC or 200 MPa HPP + SAEW with 44 mg L−1 ACC + 500 MPa HPP, producing reductions of 3.27 and 3.99 log CFU mL−1, respectively. HPP + SAEW have potentials to serve as two effective hurdle techniques for inactivating B. cereus spores.
Comparisons of physicochemical properties and antioxidant activities among pumpkin (Cucurbita moschata L.) flour and isolated starches from fresh pumpkin or flour
Authors: Promsakha na Sakon Nakhon Phanlert , Jangchud Kamolwan , Jangchud Anuvat , Prinyawiwatkul Witoon 
Published: August 2017

SummaryPhysicochemical properties (pasting and thermal properties, swelling power, water solubility and antioxidant activities) and chemical composition of pumpkin flour (PF) and starches, isolated from fresh pumpkin (SFF) or flour (SFP) were compared. SFP and SFF had similar proximate composition and amylose content. Drying process during PF preparation modified starch properties. PF exhibited greater antioxidant activities (DPPH, ABTS and FRAP), but had lower β‐carotene than fresh pumpkin. SFF and SFP had higher amylose content than PF, and exhibited a B‐type X‐ray diffraction pattern with spherical and dome‐like starch granules. Peak viscosity of SFP was relatively higher than that of SFF, probably due to lower swelling power and water solubility, which indicated increased granular rigidity in the SFP starch structure. Compared with SFF and SFP, PF had significantly higher onset (To), peak (Tp) and conclusion (Tc) temperatures due to a lower starch content and relatively higher fibre content, which resulted in lower gelatinisation enthalpy (ΔH).
Influences of argatroban on five fibrinogen assays
Authors: Zhang L. , Yang J. , Zheng X. , Fan Q. , Zhang Z. 
Published: August 2017

AbstractIntroductionArgatroban, as a direct thrombin inhibitor, prolongs the clotting time. However, detection of clotting time is the base of routine fibrinogen assays, including Clauss method and derived method. The influences of argatroban on fibrinogen assays are still unclear.MethodsNormal pooled plasma (NPP) from 20 healthy subjects was spiked with increasing argatroban concentrations (0‐3.2 μg/mL). Then the NPP samples were analyzed by five fibrinogen assays: HemosIL Fibrinogen‐C XL reagent (Clauss method) on ACL‐TOP; STA‐Fibrinogen reagent (Clauss method) on STA‐R Evolution; Siemens Thrombin reagent (Clauss method) on CS‐5100; SynthASil RecombiPlasTin 2G reagent (PT‐derived method) on ACL‐TOP; and N Antiserum to Human Fibrinogen reagent (NAHF, Immunoassay) on BN2 nephelometer analyzer.ResultsArgatroban had no influences on NAHF (P=.13). Compared with the NAHF, significant reduction was observed on Fibrinogen‐C XL (P<.01), while no influences were shown on the others (STA‐Fibrinogen: P=.41, Siemens Thrombin: P=.20, RecombiPlasTin 2G: P=.21) when activated partial thromboplastin time (APTT) ratio was no more than 3.0. As APTT ratio was increasing to 4.5, results from Clauss and PT‐derived methods were significantly lowered (STA‐Fibrinogen: P=.02, Siemens Thrombin: P<.01, Fibrinogen‐C XL: P<.01, RecombiPlasTin 2G: P<.01).ConclusionThe influences of argatroban on fibrinogen assays differ greatly, clinicians should be aware of the influences of argatroban on the fibrinogen assays used on site to avoid misdiagnoses.
Taking Root: a grounded theory on evidence‐based nursing implementation in China
Authors: Cheng L. , Broome M.E. , Feng S. , Hu Y. 
Published: August 2017

BackgroundEvidence‐based nursing is widely recognized as the critical foundation for quality care.AimTo develop a middle‐range theory on the process of evidence‐based nursing implementation in Chinese context.MethodsA grounded theory study using unstructured in‐depth individual interviews was conducted with 56 participants who were involved in 24 evidence‐based nursing implementation projects in Mainland China from September 2015 to September 2016.ResultsA middle‐range grounded theory of ‘Taking Root’ was developed. The theory describes the evidence implementation process consisting of four components (driving forces, process, outcome, sustainment/regression), three approaches (top‐down, bottom‐up and outside‐in), four implementation strategies (patient‐centred, nurses at the heart of change, reaching agreement, collaboration) and two patterns (transformational and adaptive implementation).LimitationsCertain perspectives may have not been captured, as the retrospective nature of the interviewing technique did not allow for ‘real‐time’ assessment of the actual implementation process. The transferability of the findings requires further exploration as few participants with negative experiences were recruited.ConclusionThis is the first study that explored evidence‐based implementation process, strategies, approaches and patterns in the Chinese nursing practice context to inform international nursing and health policymaking. The theory of Taking Root described various approaches to evidence implementation and how the implementation can be transformational for the nurses and the setting in which they work.Implications for nursing and health policyNursing educators, managers and researchers should work together to improve nurses’ readiness for evidence implementation. Healthcare systems need to optimize internal mechanisms and external collaborations to promote nursing practice in line with evidence and achieve clinical outcomes and sustainability.
MicroRNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy
Authors: Chen Jianliang , Yu Yue , Li Shu , Liu Yuting , Zhou Shu , Cao Shouji , Yin Jie , Li Guoqiang 
Published: August 2017

AbstractWe explored the role of microRNA‐30a (miR‐30a) and the mechanism involved in hepatic fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection in hepatic stellate cells (HSCs) (HSC‐T6, LX‐2), and miR‐30a agomir (ago‐miR‐30a) treatment in mice. MiR‐30a levels were measured using TaqMan miRNA assay system, and the localization of miR‐30a was detected by fluorescence in situ hybridization (FISH). The interaction of miR‐30a and Beclin1 was confirmed by dual‐luciferase reporter assay. Autophagic flux was analysed using tandem mRFP‐GFP‐LC3 fluorescence microscopy, electron microscopy and Western blot of LC3‐II/I ratio. MiR‐30a was notably down‐regulated in activated HSCs and LX‐2‐exosomes induced by TGF‐β1; overexpression of miR‐30a down‐regulated extracellular matrix (ECM), such as α‐SMA, TIMP‐1, and Collagen I expression, and suppressed cell viability in HSCs. MiR‐30a was significantly down‐regulated in hepatic fibrosis mice and overexpression of miR‐30a prevented BDL‐induced fibrogenesis, concomitant with the down‐regulation of ECM. MiR‐30a inhibited HSCs autophagy and increased lipid accumulation in HSCs and in mice fibrotic hepatic tissues. MiR‐30a inhibited its downstream effector of Beclin1 by direct targeting its 3′‐UTR region. Moreover, Knock‐down of Beclin1 by small interfering RNA (siRNA) inhibited HSC autophagy and activation in LX‐2 cells. In conclusion, miR‐30a is down‐regulated in hepatic fibrosis models and its overexpression prevents liver fibrogenesis by directly suppressing Beclin1‐mediated autophagy; therefore, miR‐30a may be a new potential therapeutic target for controlling hepatic fibrosis.
Blockade of myeloid differentiation protein 2 prevents obesity‐induced inflammation and nephropathy
Authors: Fang Qilu , Wang Lintao , Yang Daona , Chen Xiong , Shan Xiaoou , Zhang Yali , Lum Hazel , Wang Jingying , Zhong Peng , Liang Guang , Wang Yi 
Published: August 2017

AbstractObesity is a major and independent risk factor of kidney diseases. The pathogenic mechanisms of obesity‐associated renal injury are recognized to at least involve a lipid‐rich and pro‐inflammatory state of the renal tissues, but specific mechanisms establishing causal relation remain unknown. Saturated fatty acids are elevated in obesity, and known to induce chronic inflammation in kidneys. Myeloid differentiation protein 2 (MD2) is an important protein in lipopolysaccharide‐induced innate immunity response and inflammation. We suggested that obesity‐associated renal injury is regulated by MD2 thereby driving an inflammatory renal injury. The used three mouse models for in vivo study: MD2 knockout mice (KO) maintained on high fat diet (HFD), wild‐type mice on HFD plus L6H21, a specific MD2 inhibitor and KO mice given palmitic acid (PA) by IV injection. The in vitro studies were carried out in cultured renal tubular epithelial cells, mouse mesangial cells and primary macrophages, respectively. The HFD mice presented with increased hyperlipidemia, serum creatinine and proteinuria. Renal tissue from HFD mice had increased fibrosis, inflammatory cytokines, macrophage infiltration, and activation of NF‐κB and MAPKs. This HFD‐induced renal injury profile was not observed in KO mice or L6H21‐treated mice. Mice given PA mimmicked the HFD‐induced renal injury profiles, which were prevented by MD2 knockout. The in vitro data further confirmed MD2 mediates PA‐induced inflammation. MD2 is causally related with obesity‐associated renal inflammatory injury. We believe that MD2 is an attractive target for future therapeutic strategies in obesity‐associated kidney diseases.
The apolipoprotein A‐I mimetic peptide, D‐4F, restrains neointimal formation through heme oxygenase‐1 up‐regulation
Authors: Liu Donghui , Wu Mengzhang , Du Qian , Ding Zhenzhen , Qian Mingming , Tong Zijia , Xu Wenqi , Zhang Le , Chang He , Wang Yan , Huang Caihua , Lin Donghai 
Published: August 2017

AbstractD‐4F, an apolipoprotein A‐I (apoA‐I) mimetic peptide, possesses distinctly anti‐atherogenic effects. However, the biological functions and mechanisms of D‐4F on the hyperplasia of vascular smooth muscle cells (VSMCs) remain unclear. This study aimed to determine its roles in the proliferation and migration of VSMCs. In vitro, D‐4F inhibited VSMC proliferation and migration induced by ox‐LDL in a dose‐dependent manner. D‐4F up‐regulated heme oxygenase‐1 (HO‐1) expression in VSMCs, and the PI3K/Akt/AMP‐activated protein kinase (AMPK) pathway was involved in these processes. HO‐1 down‐regulation with siRNA or inhibition with zinc protoporphyrin (Znpp) impaired the protective effects of D‐4F on the oxidative stress and the proliferation and migration of VSMCs. Moreover, down‐regulation of ATP‐binding cassette transporter A1 (ABCA1) abolished the activation of Akt and AMPK, the up‐regulation of HO‐1 and the anti‐oxidative effects of D‐4F. In vivo, D‐4F restrained neointimal formation and oxidative stress of carotid arteries in balloon‐injured Sprague Dawley rats. And inhibition of HO‐1 with Znpp decreased the inhibitory effects of D‐4F on neointimal formation and ROS production in arteries. In conclusion, D‐4F inhibited VSMC proliferation and migration in vitro and neointimal formation in vivo through HO‐1 up‐regulation, which provided a novel prophylactic and therapeutic strategy for anti‐restenosis of arteries.