bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Phytochemicals as Potential Inhibitors of Cancer Cell Metabolic Pathways: A Computational Study
Authors: Kapoor Yagyesh , Hasija Yasha 
Published: October 2024

Objective:
The objective of this study is to explore the therapeutic potential of phytochemicals
in cancer cell metabolism by investigating their ability to inhibit key molecular targets
involved in tumor growth and drug resistance.

Methods:
We evaluated specific phytochemicals against critical cancer-related targets such as
GLS1, CKα, MGLL, IDH1, PDHK1, and PHGDH. Molecular docking methods were used to understand
the binding interactions between phytochemicals and their selected targets. ADME (absorption,
distribution, metabolism, and excretion) analysis and molecular dynamics (MD) simulations
were conducted to assess pharmacokinetic properties and ligand-protein interaction dynamics,
respectively. MM-PBSA (molecular mechanics Poisson-Boltzmann surface area) calculations were
utilized to estimate binding free energies.

Results:
Molecular dynamics simulations demonstrate that phytochemicals like EGCG, Diosgenin,
Withaferin A, and Celastrol exhibit stable binding to their respective targets, suggesting potential
therapeutic benefits. Specifically, EGCG shows strong and non-toxic binding affinity with GLS1,
making it a promising candidate for cancer treatment.

Conclusion:
Our study underscores the potential of phytochemicals as effective inhibitors of cancer
cell metabolism. The stable binding interactions highlight promising avenues for developing innovative
cancer therapies. Further experimental investigations are warranted to validate these findings
and advance the development of hybrid phytochemical-based treatments for combating chemoresistance.
scADCA: An Anomaly Detection-Based scRNA-seq Dataset Cell Type Annotation Method for Identifying Novel Cells
Authors: Shi Yongle , Ma Yibing , Chen Xiang , Gao Jie 
Published: October 2024

Background:
With the rapid evolution of single-cell RNA sequencing technology, the
study of cellular heterogeneity in complex tissues has reached an unprecedented resolution. One
critical task of the technology is cell-type annotation. However, challenges persist, particularly in
annotating novel cell types.

Objective:
Current methods rely heavily on well-annotated reference data, using correlation comparisons
to determine cell types. However, identifying novel cells remains unstable due to the inherent
complexity and heterogeneity of scRNA-seq data and cell types. To address this problem, we propose
scADCA, a method based on anomaly detection, for identifying novel cell types and annotating
the entire dataset.

Methods:
The convolutional modules and fully connected networks are integrated into an autoencoder,
and the reference dataset is trained to obtain the reconstruction errors. The threshold based on
these errors can distinguish between novel and known cells in the query dataset. After novel cells
are identified, a multinomial logistic regression model fully annotates the dataset.

Results:
Using a simulation dataset, three real scRNA-seq pancreatic datasets, and a real scRNA-seq
lung cancer cell line dataset, we compare scADCA with six other cell-type annotation methods,
demonstrating competitive performance in terms of distinguished accuracy, full accuracy, F!-score,
and confusion matrix.

Conclusion:
In conclusion, the scADCA method can be further improved and expanded to achieve
better performance and application effects in cell type annotation, which is helpful to improve the
accuracy and reliability of cytology research and promote the development of single-cell omics.
Bulky Isolated Adrenal Metastasis as First Presentation of Occult Hepatocellular Carcinoma (HCC) in a Patient with a Synchronous Squamous Carcinoma of the Tongue
Authors: Lodin Marco , Ragni Alberto , Renzelli Valerio , Rossi Maura , Traverso Elena Silvia , Gallo Marco 
Published: October 2024

Background:
The diagnostic workup of an adrenal mass should always rule out the possibility
of an adrenal metastasis, especially in a patient followed-up for a known primitive cancer.
Sometimes, however, the incidental finding of a bulky lesion in a cancer patient can lead to the unexpected
diagnosis of metastasis from a second occult cancer. Here, we report the case of a voluminous,
isolated left adrenal metastasis from unknown and persistently occult hepatocellular carcinoma
(HCC), incidentally found during the follow-up for squamous carcinoma of the tongue.

Case Description:
A 72-year-old HBV/HCV-negative male patient with a history of alcohol abuse
was referred to our hospital for gastric bleeding. Some weeks before, the patient was operated on
for a locally advanced squamous cell carcinoma of the tongue, which required cervical lymph
node neck dissection, temporary tracheostomy, jejunostomy, and plastic reconstruction. Subsequent
diagnostic imaging revealed a left adrenal mass sized 9x15 cm with suspicious features. The
hormonal workout was negative for pheochromocytoma and a hyperfunctioning adrenal lesion.
The patient underwent laparotomic left adrenalectomy. The exploration of the liver was compatible
with alcoholic cirrhosis and did not reveal any other palpable lesion. The adrenal mass histologically
turned out to be a poorly differentiated G3 HCC. Subsequent radiological exams were unable
to identify the primary liver lesion or any other neoplasms. Conversely, α-FP levels were initially
high but reduced after treatment with sorafenib. After 2 years of follow-up, the patient is
alive and well, albeit with evidence of locoregional inter-aortocaval lymphadenopathy. The primary
HCC has never been identified, thus suggesting the hypothesis of a diffuse cirrhosis-like
HCC.

Conclusion:
The suspicion of an adrenal metastasis in a patient with primary cancer with a low potential
for adrenal metastatic spreading must raise the diagnostic suspect for another synchronous
occult cancer beyond that for primary adrenal cancer. HCC can rarely first manifest as a metastatic
adrenal lesion.
Platelet-rich Plasma for the Treatment of Neuropathic Pain: A Systematic Review
Authors: de Jesus Larissa Santana , Nepomuceno Ana Flávia Souto Figueiredo , Couto Ricardo David , Villarreal Cristiane Flora 
Published: October 2024

Background:
Neuropathic pain (NP) presents a significant actual public health challenge.
Traditional treatments primarily involve medications, but these approaches frequently yield
unsatisfactory results, highlighting the need to explore alternative therapies, such as platelet-rich
plasma (PRP), an autologous plasma derivative enriched with platelets.

Objective:
This article aims to systematically review the literature and provide an updated assessment
of the efficacy and safety of PRP treatment for NP.

Methods:
Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
guidelines, we searched databases, including Web of Science, Embase, PubMed, Scopus,
and Cochrane Library. We assessed bias risk using the Cochrane Risk of Bias 2 tool (RoB2).

Results:
Among 1230 studies identified, 12 randomized trials meeting eligibility criteria were included.
Due to substantial heterogeneity, pairwise meta-analysis and intervention ranking were
found to be unfeasible. Most trials suggest PRP is effective in relieving NP, with no reported serious
complications or significant PRP-related adverse effects. However, these findings were compromised
by methodological heterogeneity and study inconsistency.

Conclusion:
PRP has shown to be promising as a safe therapeutic option for managing NP. Future
studies should prioritize improved rigor and reproducibility for more stringent conclusions.
Metode Pembelajaran Tanya Jawab untuk Meningkatkan Pemahaman Matematika Siswa Tuna Grahita di SLB Ganda Daya Ananda
Authors: Sadiyah Halimatus , Aini Aulia Nurul 
Published: October 2024

Sekolah Luar Biasa (SLB) Ganda Daya Ananda adalah salah satu sekolah yang melayani siswa dengan berbagai kebutuhan khusus. Dimana dalam sekolah ini siswa tidak dituntut untuk dapat mengikuti kurikulum yang ada, namun belajar sesuai dengan kemampuan mereka. Pengabdian ini dilakukan adalah untuk mengetahui metode yang tepat dalam pembelajaran matematika anak tunagrahita. Guru dapat melakukan pembelajaran yang sesuai bagi anak-anak dengan kebutuhan khusus tunagrahita. Guru harus perlahan dalam menjelaskan materi matematika yang ada sehingga anak anak tunagrahita dapat memahami pembelajaran yang ada. Hal tersebut karena pelajaran matematika merupakan pelajaran yang abstrak dan membutuhkan pemahaman yang lebih dibandingkan pelajaran-pelajaran yang lain. Kemudian sulitnya menerima materi oleh anak tunagrahita karena akademiknya terhambat. Pemebelajaran yang dilakukan adalah dengan pengajar harus bisa menguasai kelas, harus aktif berkomunikasi dengan siswa, dan juga menggunakan media pembelajaran. Hal tersebut efektif dalam meningkatkan pemahaman matematika siswa tunagrahita
Evaluating the Impact of a Daylight-Simulating Luminaire on Mood, Agitation, Rest-Activity Patterns, and Social Well-Being Parameters in a Care Home for People With Dementia: Cohort Study
Authors: Turley Kate , Rafferty Joseph , Bond Raymond , Mulvenna Maurice , Ryan Assumpta , Crawford Lloyd 
Published: October 2024

Abstract

Background
Living with a diagnosis of dementia can involve managing certain behavioral and psychological symptoms. Alongside cognitive decline, this cohort expresses a suppression in melatonin production which can negatively influence their alignment of sleep or wake timings with the 24 hour day and night cycle. As a result, their circadian rhythms become disrupted. Since daylight has the capacity to stimulate the circadian rhythm and humans spend approximately 90% of their time indoors, research has shifted toward the use of indoor lighting to achieve this same effect. This type of lighting is programmed in a daylight-simulating manner; mimicking the spectral changes of the sun throughout the day. As such, this paper focuses on the use of a dynamic lighting and sensing technology used to support the circadian rhythm, behavioral and psychological symptoms, and well-being of people living with dementia.

Objective
This study aimed to understand how dynamic lighting, as opposed to static lighting, may impact the well-being of those who are living with dementia.

Methods
An ethically approved trial was conducted within a care home for people with dementia. Data were collected in both quantitative and qualitative formats using environmentally deployed radar sensing technology and the validated QUALIDEM (Quality of Life for People With Dementia) well-being scale, respectively. An initial 4 weeks of static baseline lighting was used before switching out for 12 weeks of dynamic lighting. Metrics were collected for 11 participants on mood, social interactions, agitation, sense of feeling, and sleep and rest-activity over a period of 16 weeks.

Results
Dynamic lighting showed significant improvement with a moderate effect size in well-being parameters including positive affect (P=.03), social isolation (P=.048), and feeling at home (P=.047) after 5‐10 weeks of dynamic lighting exposure. The results also highlight statistically significant improvements in rest-activity–related parameters of interdaily stability (P<.001), intradaily variation (P<.001), and relative amplitude (P=.03) from baseline to weeks 5‐10, with the effect propagating for interdaily stability at weeks 10‐16 as well (P<.001). Nonsignificant improvements are also noted for sleep metrics with a small effect size; however, the affect in agitation does not reflect this improvement.

Conclusions
Dynamic lighting has the potential to support well-being in dementia, with seemingly stronger influence in earlier weeks where the dynamic lighting initially follows the static lighting contrast, before proceeding to aggregate as marginal gains over time. Future longitudinal studies are recommended to assess the additional impact that varying daylight availability throughout the year may have on the measured parameters.
High-Resolution Eye-Tracking System for Accurate Measurement of Short-Latency Ocular Following Responses: Development and Observational Study
Authors: Miladinović Aleksandar , Quaia Christian , Kresevic Simone , Ajčević Miloš , Diplotti Laura , Michieletto Paola , Accardo Agostino , Pensiero Stefano 
Published: October 2024

Abstract

Background
Ocular following responses (OFRs)—small-amplitude, short-latency reflexive eye movements—have been used to study visual motion processing, with potential diagnostic applications. However, they are difficult to record with commercial, video-based eye trackers, especially in children.

Objective
We aimed to design and develop a noninvasive eye tracker specialized for measuring OFRs, trading off lower temporal resolution and a smaller range for higher spatial resolution.

Methods
We developed a high-resolution eye-tracking system based on a high-resolution camera operating in the near-infrared spectral range, coupled with infrared illuminators and a dedicated postprocessing pipeline, optimized to measure OFRs in children. To assess its performance, we: (1) evaluated our algorithm for compensating small head movements in both artificial and real-world settings, (2) compared OFRs measured simultaneously by our system and a reference scleral search coil eye-tracking system, and (3) tested the system’s ability to measure OFRs in a clinical setting with children.

Results
The simultaneous measurement by our system and a reference system showed that our system achieved an in vivo resolution of approximately 0.06°, which is sufficient for recording OFRs. Head motion compensation was successfully tested, showing a displacement error of less than 5 μm. Finally, robust OFRs were detected in 16 children during recording sessions lasting less than 5 minutes.

Conclusions
Our high-resolution, noninvasive eye-tracking system successfully detected OFRs with minimal need for subject cooperation. The system effectively addresses the limits of other OFR measurement methods and offers a versatile solution suitable for clinical applications, particularly in children, where eye tracking is more challenging. The system could potentially be suitable for diagnostic applications, particularly in pediatric populations where early detection of visual disorders like stereodeficiencies is critical.
Development and evaluation of a novel force myography (FMG) based human-machine interface for transradial prosthetics: A comparative study with electromyography (EMG) techniques
Authors: Jan Azam , Haq Ihtisham Ul , Anas Muhammad , Husnain Ghassan , Ahmad Waqas 
Published: October 2024

Human-Machine Interfaces (HMIs) must bridge human skills with machine control, notably in active prosthesis. Electromyography (EMG) is the most popular prosthesis actuation method. However, researchers need new HMIs for active prosthesis development. This research introduces Forcemyography (FMG) based HMI using force- sensitive resistors (FSRs) to capture myoelectric data. A particularly constructed case with two integral parts—an internal and an exterior component—is FMG. This FMG enclosure adapts effortlessly to the user's limb and shape for best performance and comfort. FMG and sEMG were compared in the experimental evaluation. Stability, forecast accuracy, hair and sweat resistance, wearability, and cost-effectiveness were examined. FMG signals outperformed sEMG signals in this comprehensive examination. FMG outperformed sEMG in stability and prediction accuracy. FMG produced outstanding results right from capture without post-processing, a unique advantage. The specialised enclosure protected FSRs from outside interference and delivered precise signals. The Forcemyography (FMG)-based HMI is a breakthrough in active prosthesis technology. Its versatility, consistent signal acquisition, and user-centric design promise improved human-machine interactions. FMG leads the way to smooth, intuitive, and efficient humanmachine interface.
Evaluation of the accuracy of digital indirect bonding vs. conventional systems: a randomized clinical trial
Authors: Soares Ueno Eloisa Peixoto , de Carvalho Teresa Cristina Alvez da Silva Gonzalez , Kanashiro Lylian Kazumi , Ursi Weber , Chilvarquer Israel , Neto José Rino , de Paiva João Batista 
Published: October 2024

ABSTRACT

Objectives
To compare the accuracy and chair time of self-ligating brackets using direct bonding, traditional indirect bonding (IB), and computer-aided design/computer-aided manufacturing (CAD/CAM) IB techniques after orthodontic leveling and alignment.

Materials and Methods
Forty-five patients were randomly assigned to three bonding groups (G1 [n = 15], G2 [n = 15], and G3 [n = 15]). Evaluation after the alignment and leveling phases used two parameters of the objective grading system of the American Board of Orthodontics for root parallelism and posterior marginal ridges, assessed using panoramic radiographies (PR I and PR II), a digital model, and a plaster model. Blinding was only applied for outcome assessment. No serious harm was observed except for gingivitis associated with plaque accumulation.

Results
Although G3 showed better numerical results, they were not statistically significant in the radiographic or model evaluations (P &gt; .001). Mean chair time was significantly shorter in G3 (1.1 ± 11.8 min) vs. G1 (56.7 ± 7.3 min) and G2 (52.8 ± 8.3 min; P &lt; .001).

Conclusions
The CAD/CAM IB system for self-ligating brackets was as effective as conventional methods, with a shorter chair time.
Digitalization of the Electoral Process in Russia: Legal Aspects
Authors: Makhova A. V. , Rokotyanskaya A. A. 
Published: October 2024

Introduction. Digitalization is a distinctive feature of development of the modern society, which implies intensive implementation of the new technologies into the different spheres of life, including the electoral process. In Russia, the development of measures efficiently ensuring the suffrage of the citizens, the improvement of the legal regulation of the electoral process are being carried out for more than thirty years. However, the dynamics of automation and digitalization of the electoral procedures often outrides their theoretical justification and legal comprehension. The works of Russian and foreign authors study the problems of the electoral process digitalization, the electronic forms of manifesting the civic activity and political engagement. A number of researchers consider the ongoing changes to be inevitable and call for a revision of the electoral process basic fundamentals, others propose to limit this process indicating on the impossibility to ensure the absolute information security. The paper aims at analysing the main stages of automation and digitalization of the electoral process in Russia, identify the problems associated with implementation of the new technologies and develop recommendations for the efficient transformation of the electoral system in the context of digitalization.Materials and Methods. To ensure the relevance and reliability of the obtained results, the general and specific scientific methods of cognition were used in the research: the dialectical method, the method of juridical comparativistics, as well as the content analysis of the regulatory legal acts and historical, systemic, logical and other methods. Various methods of interpreting the legal norms were used to identify the regularities in their application. The content analysis of the regulatory legal acts and the logical method made it possible to identify the electoral process digital transformation features. The method of modeling enabled formulation of the proposals on improving the legislation.Results. The main stages of automation and digitalization of the electoral process have been studied. Their features and problems have been identified. The need for transformation of the legal regulation, capable of efficient ensuring the suffrage of the citizens in the new conditions, has been substantiated.Discussion and Conclusion. Based on the results of the research, the recommendations have been developed for efficient legal regulation of the main stages of the electoral process in the context of digitalization. The theoretical conclusions formulated by the authors are proposed to be used for further research and improvement of the current electoral law of the Russian Federation.
Systematisation of Conceptual Approaches to Formation of Business Ethics in the Context of Legal Regulation of Entrepreneurial Activity
Authors: Shumilina A. B. , Antsiferova N. A. 
Published: October 2024

Introduction. In the frame of entrepreneurship development, promotion of business ethics becomes particularly important as a mechanism for business harmonization, ensuring legal equality, healthy competition and fair attitudes to consumers. However, the controversial approaches to defining the concept of “business ethics” and the multiple interpretations thereof prevent from boosting the global spread of business culture in the legal regulation framework. In this regard, the aim of the study is to systematise the conceptual approaches to substantiation and formation of business ethics in the context of legal regulation of entrepreneurial activity.Materials and Methods. The methodological basis of the research includes the general and specific scientific methods. The methods of analysis, comparison and systematisation enable the study of the integral parts of business ethics to get deep understanding of this concept. By comparing different interpretations, the common grounds in the interdisciplinary approaches to substantiation of this concept are revealed. Systematisation fosters organisation of the legal and moral values into a single hierarchical structure that forms the essence of business ethics. The philosophical-juridical method reveals the interrelation of the philosophical approach contained in the entrepreneurial value reference points and the legislative norms of society.Results. The research has revealed a pattern of business ethics development in the context of global and national wellbeing. The hierarchical structure of business ethics has a top-down nature: the international level, the macro level and the micro level. Despite the influence of cultural specifics on the development of the moral value system, the formation of business culture should go in correlation with the norms of law and the needs of society, along with establishment of the corporate boundaries and general entrepreneurial principles. At the corporate level, the integration of business ethics into the enterprise strategy is beneficial for its image and reputation, and the efficiency lies in promotion of the socio-economic, legal and other aspects fostering creation of fair, sustainable and conscious business.Discussion and Conclusion. The concept of “business ethics” is studied in the various scientific contexts. Despite all differences in interpretation, the mechanism of forming the business ethics in the framework of entrepreneurial activity is uniform, it includes creation of the code of ethics, training in ethical principles, development of a system of incentives, elaboration of the methods of prevention and punishment. In various contexts, this mechanism is aimed at eliminating unlawful forms of competition, ensuring economic, social and legal security, increasing the level of responsibility and creating an efficient system of business values.