bluuebunny/crossref_metadata_2025_split huggingface dataset:
More knowledge, more choices? How peer recognition of physicians’ knowledge sharing affect patients’ consultation in online health communities
Authors: Xu Zhen , Liu Xiaochen , Meng Lingguang , Lyu Xuanxuan 
Published: October 2024

BackgroundThe advent of telemedicine has revolutionized healthcare consultations, primarily due to the digital era and global health concerns. Online healthcare communities (OHCs) have emerged as platforms for physicians to share health-related articles, promoting digital public health awareness and knowledge dissemination. The continuous dissemination of health knowledge by physicians online is considered a crucial driving force in attracting patients to seek online consultations.MethodsBased on the elaboration likelihood model and the information overload theory, this study explores how persuasive messages from other patients’ peer recognition, including knowledge popularity and attractiveness, affect patients’ consultation decisions. Additionally, the study examines the three-way interaction between knowledge popularity, attractiveness, and quantity in shaping patient consultations. Using data collected from 2,676 physicians on haodf.com, this study established an ordinary least squares (OLS) regression model with time and city fixed effects to test the hypothesis.ResultsThe results show that: (1) peer recognition (knowledge popularity and attractiveness) from other patients positively impacts patients’ consultation; (2) knowledge attractiveness positively moderate the relationship between knowledge popularity and patients’ consultation; (3) there is a three-way effect of knowledge popularity, knowledge attractiveness, and knowledge quantity on patients’ consultation.ConclusionOur findings offer valuable guidance for platform design and healthcare practitioners, boosting patient-physician engagement in online healthcare communities.
Determinants of medication non-adherence among patients with chronic diseases at community pharmacy settings in South Gondar Zone, Northwest Ethiopia: a multicenter cross-sectional study
Authors: Moges Tilaye Arega , Dagnew Samuel Berihun , Wondm Samuel Agegnew , Ferede Yared Andargie , Yiblet Tesfagegn Gobezie , Almaw Andargachew , Shumet Yimer Yohannes , Tesfaw Addis Getu , Zewdu Woretaw Sisay , Dagnew Fisseha Nigussie 
Published: October 2024

BackgroundMedication non-adherence is a significant public health concern in managing patients with chronic diseases, and community pharmacists are on the frontline in the management of chronic medications. Chronic diseases require lifelong pharmacotherapy and understanding the determinants of medication adherence has paramount importance to develop strategies that improve medication adherence and treatment outcomes. Thus, this study aimed to assess the magnitude of medication non-adherence and its contributing factors among patients with chronic diseases attending community pharmacies in South Gondar Zone, Northwest Ethiopia.MethodsA multicenter cross-sectional study was conducted at community pharmacies in South Gondar Zone from September 01 to October 30, 2023. Medication adherence was assessed using a structured questionnaire using the Adherence in Chronic Diseases Scale (ACDS). Statistical Package for Social Sciences (SPSS) version 25 was used for analysis. Association between the outcome variable and independent variables was performed using binary logistic regression and a p-value of &lt;0.05 was considered statistically significant.ResultsAmong three hundred and eighty six (386) study participants recruited in this study, more than half of them 222 (57.51%, 95%CI: 52.4% - 62.5%) were low adherent to their medications. Concerning determinants of medication non-adherence; the presence of side effects (AOR =2.1, 95%CI=1.33-3.29), unable to get ever counseling from community pharmacists (AOR=2.3, 95%CI= 1.46-3.58), and poor about their medications (AOR=3.1, 95% CI= 1.96-4.82) were significantly associated with patients’ non-adherence to medications.ConclusionThe medication adherence level in this study was suboptimal, with a significant proportion of the patients being non-adherent to their medications. The presence of side effects, unable to get ever counseling, and poor knowledge about their medications were statistically significant factors of poorer medication adherence. Hence, healthcare professionals, especially community pharmacists, have a crucial role in designing the schedule for health education concerning the needs of these patients in community pharmacy settings.
Impact of caring for patients with polyhandicap on institutional health care workers’ quality of life: a cross-sectional and longitudinal evaluation
Authors: Rousseau Marie-Christine , Beltran Any , Hamouda Ilyes , Aim Marie-Anastasie , Felce Agnès , Lind Katia , Khaldi Nafissa , El Ouazzani Houria , Auquier Pascal , Villemeur Thierry Billette de , Baumstarck Karine 
Published: October 2024

BackgroundProfound intellectual multiple disabilities or polyhandicap (PLH) is defined as a combination of profound mental retardation and serious motor deficits resulting in extreme dependence. Support for these patients is multidisciplinary, complex, and time-consuming. Thus, institutional health care workers (HCWs) face specific working conditions: frequent physical tasks, distressed families, and restricted feedback.ObjectivesWe aimed to identify determinants of quality of life (QoL) of HCWs and to study longitudinal evolution.MethodsThe study used data from the French cohort EVAL-PLH. The participants were institutional HCWs of persons with PLH (age ≥ 3 years at the time of inclusion; age at onset of cerebral lesion &lt;3 years old). Two populations were used: (1) cross sectional study: the sample 1 includes the HCWs assessed at T2 (2020–2021); (2) longitudinal study: the sample 2 includes the HCWs assessed at both T1 (2015–2016) and T2 (2020–2021). The data collected included: sociodemographics, health status, professional variables, and psycho-comportemental aspects. QoL was assessed using WHOQOL-BREF which provides 4 scores.ResultsIn comparison with French norms, the physical and social scores of QoL were significantly lower while the psychological score was significantly higher for (i) the 223 HCWs (participation rate 62%) assessed at T2 and (ii) the 61 HCWs assessed at T1 and T2. The main factors modulating QoL were age, marital status, self-perceived financial difficulties, personal chronic disease, anxiety-mood disorders, nature of coping strategies, and burnout.ConclusionThis study confirms the mixed (negative and positive) impact of caring persons with PLH on the institutional HCWs’ QOL. Main determinants of the HCW’s QOL were: older age, single status, perceived financial difficulties, altered health status, burn out and coping strategies.Clinical trial registration number: NCT02400528.
Long-term-survival phase cells of Salmonella enteritidis ATCC 13076 exhibit significantly greater tolerance to atmospheric cold plasma treatment of shell eggs
Authors: Barry Kia , Mendonça Aubrey , Phillips Gregory J. , Boylston Terri , Fortes-Da-Silva Paulo , Brehm-Stecher Byron , Juneja Vijay , Wan Zifan 
Published: October 2024

The main objective of this study was to evaluate the tolerance of stationary phase (STAT) and long-term survival phase (LTS) Salmonella Enteritidis ATCC 13076 to atmospheric cold plasma (ACP) in phosphate buffered saline (PBS, pH 7.0) and on shell eggs. Salmonella Enteritidis was cultured in tryptic soy broth supplemented with 0.6% (w/v) yeast extract (35°C) for 20 h (STAT) and 21 days (LTS). Cell morphology was determined by light microscopy. The PBS and shell eggs were inoculated with STAT or LTS cells to obtain ∼7.0 log10 CFU/mL or egg. The ACP was applied at 45 kV (PBS) and 60 kV (shell eggs) for 1–4 min and 1–5 min, respectively. Pathogen survivors were enumerated on thin agar layer (TAL) medium and on xylose lysine tergitol-4 (XLT-4) agar after 48 h of incubation (35°C). For survivors on shell eggs, R2 and mean square error values were obtained using Log-linear with Tail and Weibull models. The STAT cells were predominantly rod-shaped whereas LTS cells were coccoid. In PBS, reductions (log10 CFU/mL) of STAT cells were 1.0, 0.95, 1.45, and 1.44 after exposure to ACP for 1, 2, 3, and 4 min, respectively. In contrast, reductions in LTS cells were significantly lower (p&lt; 0.05) at 0.04 (1 min), 0.06 (2 min) 0.01 (3 min), and 0.11 (4 min). A similar pattern was observed for shell eggs whereby LTS cells exhibited much higher tolerance to ACP than STAT cells (p &lt; 0.05). The Log-linear with Tail model produced a better fit of the survival data for STAT cells; times to achieve a 4- and 5- log reduction were 5.29 and 5.78 min, respectively. Sub-lethal injury occurred in both STAT and LTS survivors; however, differences were not significant (P &gt; 0.05). Additionally, there were no observed differences in shell strength and yolk color between ACP-treated and control eggs. Based on these results, LTS cells of S. Enteritidis are more tolerant to ACP than STAT cells and should be considered when developing process validation protocols involving application of ACP to inactivate Salmonella on shell eggs.
Chemical Composition, Antibacterial and Antibiotic-Modifying Activity of Croton grewioides Baill Essential Oil
Authors: Viturino José Jonas Ferreira , Camilo Cicera Janaine , de Carvalho Natália Kelly Gomes , Nascimento Joice Barbosa do , da Silva Maria Inacio , Pereira da Silva Mariana , Castro José Walber Gonçalves , Souza Geane Gabriele de Oliveira , Rodrigues Fabíola Fernandes Galvão , da Costa José Galberto Martins 
Published: October 2024

Background: Croton grewioides Baill., a species native to the Caatinga, popularly known as canela de cunhã, is used in traditional medicine to treat gastrointestinal diseases such as diarrhea, gastritis and stomach ulcers. The combination of essential oils with antibiotics reveals several beneficial effects associated with the increased efficacy of these drugs against pathogenic agents. Through this perspective, this study aimed to identify the chemical composition of the essential oil of C. grewioides (OECG) and evaluate its antibacterial and antibiotic-modifying activities against standard and multiresistant bacteria. Methods: To analyze the compounds present in the oil, the techniques of gas chromatography coupled with mass spectrometry (GC/MS) and gas chromatography with a flame ionization detector (GC/FID) were used. In the bacteriological tests, the Minimum Inhibitory Concentration (MIC) was obtained by the broth microdilution technique. The modulating effect of the essential oil was determined by calculating the subinhibitory concentration, followed by a serial microdilution of the antibiotics. The MIC reduction factor (CRF) was calculated, and its data were expressed as a percentage. Results: The analysis of the chemical composition identified the presence of the major compound estragole with a relative abundance of 50.34%. The MIC values obtained demonstrated efficacy in K. pneumoniae isolated from urine with MIC values of 512 µg/mL. OECG potentiated the effects of all antibiotics tested on the strains S. aureus ATCC 29213, K. pneumoniae Carbapnemase, E. coli ATCC 25922 and S. aureus ATCC 29213 with their CRF of 97.65%, 99.80%, 99.85% and 99.88%, respectively. Conclusions: Thus, the essential oil of C. grewioides presents synergistic effects when combined with the antibiotics tested, in addition to acting in the fight against bacterial resistance to antibiotics.
Оценка воздушной и водной сред в безнапорных водоотводящих сетях и мероприятия по снижению уровня запахов и газообразования
Authors: Орлов В.А. , Примин О.Г. 
Published: October 2024

Одной из глобальных проблем городского хозяйства является обеспечение комфортности проживания людей, где наибольшее внимание должно уделяться таким аспектам, как чистота воды и воздуха. Изучению и оценке подлежит нормативно-техническая документация по анализу городской воздушной среды и сточных вод, транспортируемых по самотечным водоотводящим сетям, в подсводном пространстве которых наблюдается наличие дурнопахнущих газов. Рассмотрены источники загрязнения вредными для здоровья человека запахами, являющимися результатом протекания интенсивных биохимических процессов в безнапорных сетях, а также проанализированы мероприятия, позволяющие снизить или ликвидировать пагубные последствия вредных для здоровья человека газов. Проведен аналитический обзор результатов потенциального анализа проб сточной воды и воздуха, содержащегося в подсводном пространстве водоотводящих сетей. Отмечено, что некоторые виды микроорганизмов, находящихся в замкнутом воздушном пространстве канализационных колодцев, способны оказывать негативное воздействие на человеческий организм, что представляет угрозу здоровью обслуживающему персоналу водоотводящих сетей при проведении им работ в колодцах без средств индивидуальной защиты дыхательных путей. Рассмотрены химические, механические и гидродинамические методы нейтрализации веществ, провоцирующих появление запахов.
One of the global tasks of the municipal services is to ensure comfortable living conditions for people, for which purpose the greatest attention should be paid to such aspects as clean water and air. The regulatory and technical documentation on the analysis of the urban air and wastewater transported through gravity sewers with malodorous gases present in the underroof space, are subject to study and assessment. The sources of pollution with odors detrimental to human health that result from the intensive biochemical processes in gravity networks are considered, as also measures are analyzed to reduce or eliminate the harmful effects of gases detrimental to human health. An analytical review of the results of potential analysis of samples of wastewater and air in the underroof space of sewers was conducted. It was noted that some types of microorganisms present in the enclosed airspace of sewer manholes could produce a negative impact on the human body, i.e. pose health risks to the maintenance staff of sewer networks while working in manholes without individual respiratory protective means. Chemical, mechanical and hydrodynamic methods for neutralizing substances that provoke the appearance of malodors are considered.
Hydrodynamics and Nucleosynthesis of Jet-driven Supernovae. II. Comparisons with Abundances of Extremely Metal-poor Galaxies and Constraints on Supernova Progenitors
Authors: Leung Shing-Chi , Nomoto Ken’ichi 
Published: October 2024

Abstract
The spectra of several galaxies, including extremely metal-poor galaxies from EMPRESS, have shown that the abundances of some Si-group elements differ from “spherical” explosion models of massive stars. This leads to the speculation that these galaxies have experienced supernova explosions with high asphericity, where mixing and fallback of the inner ejecta with the outer material lead to the distinctive chemical compositions. In this paper, we consider the jet-driven supernova models by direct 2D hydrodynamics simulations using progenitors of about 20–25 M
⊙ at zero metallicity. We investigate how the abundance patterns depend on the progenitor mass, mass cut, and asphericity of the explosion. We compare the observable with available supernova and galaxy catalogs based on 56Ni, ejecta mass, and individual element ratios. The proximity of our results with the observational data signifies the importance of aspherical supernova explosions in chemical evolution of these galaxies. Our models will provide the theoretical counterpart for understanding the chemical abundances of high-z galaxies measured by the James Webb Space Telescope.
The Most Massive Early-type Galaxies Exhibit Tidal Features More Frequently in Lower-density Environments
Authors: Yoon Yongmin , Kim Jae-Woo , Ko Jongwan 
Published: October 2024

Abstract
The most massive early-type galaxies (ETGs) are known to form through numerous galaxy mergers. Thus, it is intriguing to study whether their formation in low-density environments, where nearby companions are almost absent, is associated with mergers, which are directly traced by tidal features. Using the 436 most massive ETGs with M
star > 1011.2
M
⊙ at z < 0.04, we determine the variation in the fraction of massive ETGs with tidal features (f

T
) across different environments and verify whether the most massive ETGs commonly have tidal features in very low density environments. Our main discovery is that the most massive ETGs exhibit tidal features more frequently in lower-density environments. In the highest-density environments, like galaxy clusters, f

T
is 0.21 ± 0.06, while in the lowest-density environments it triples to 0.62 ± 0.06. This trend is stronger for more extremely massive ETGs, with f

T
reaching 0.92 ± 0.08 in the lowest-density environments. One explanation for our finding is that the most massive ETGs in lower-density environments have genuinely experienced recent mergers more frequently than their counterparts in higher-density environments, suggesting that they possess extended formation histories that continue into the present. Another possibility is that tidal features last shorter in denser environments owing to external factors inherent in these environments. Our additional findings that massive ETGs with bluer u − r colors are a more dominant driver of our main discovery and that dust lanes are more commonly observed in massive ETGs in low-density environments imply that gas-abundant mergers primarily contribute to the increased rate of recent mergers in low-density environments.
Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation
Authors: Dhital Ravi , Flint Kaitlyn , Kaptsan Irina , Hegde Shweta , Daloul Reem , Shimamura Masako 
Published: October 2024

Abstract
CMV infection and Th17 cells are independently associated with increased risk for late allograft loss after renal transplantation. Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear. This prospective observational study evaluated a cohort of renal transplant recipients during 12 mo posttransplant to assess the presence of CMV-specific Th17 cells in peripheral blood and their relationship to pretransplant CMV serostatus and CMV DNAemia. CMV-specific Th17 cells were identified among CMV serostatus donor (D)+ and/or recipient (R)+ recipients and expanded during both primary (D+/R−) and reactivated (D+/R+, D−/R+) CMV DNAemia. A subset of CMV-specific Th17 cells coexpressed IFN-γ, indicating a Th1/17 phenotype. These Th17 and Th1/17 cells expressed CCR6, CCR5, activation and terminal differentiation markers (CD95, OX40, HLA-DR, CD57), and a central/effector memory phenotype. CMV-specific Th1/17 cells expressed activating/inhibitory receptors (CD57, 4-1BB, CD160, CTLA-4, PD-1) at higher frequencies than Th17 cells. In contrast, staphylococcal enterotoxin B–induced Th17 cells did not expand during CMV DNAemia, did not differ between CMV serostatus groups over time, expressed CCR6, predominantly coexpressed TNF-α, and had lower expression of activating and inhibitory receptors than pp65-specific Th17 and Th1/17 cells. These data show that CMV-specific Th17 cells expand during episodes of CMV DNAemia among renal transplant recipients, and that these virus-specific Th17 and Th1/17 cells have distinct phenotypes from global circulating Th(1)/17 cells. These results suggest a potential proinflammatory pathway by which CMV-induced Th17 cells may contribute to allograft injury, increasing risk for late allograft loss.
Study on the influence of the sY1192 gene locus in the AZFb/c region on sperm quality and pregnancy outcome
Authors: Chen Gang-Xin , Sun Yan , Yang Rui , Huang Zhi-Qing , Li Hai-Yan , Zheng Bei-Hong 
Published: October 2024

Abstract
Y chromosome microdeletions are an important cause of male infertility. At present, research on the Y chromosome is mainly focused on analyzing the loss of large segments of the azoospermia factor a/b/c (AZFa/b/c) gene, and few studies have reported the impact of unit point deletion in the AZF band on fertility. This study analyzed the effect of sperm quality after sY1192 loss in 116 patients. The sY1192-independent deletion accounted for 41.4% (48/116). Eight patterns were found in the deletions associated with sY1192. The rate of sperm detection was similar in the semen of patients with the independent sY1192 deletion and the combined sY1192 deletions (52.1% vs 50.0%). The patients with only sY1192 gene loss had a higher probability of sperm detection than the patients whose sY1192 gene locus existed, but other gene loci were lost (52.1% vs 32.0%). The hormone levels were similar in patients with sY1192 deletion alone and in those with sY1192 deletion and other types of microdeletions in the presence of the sY1192 locus. After multiple intracytoplasmic sperm injection (ICSI) attempts, the pregnancy rate of spouses of men with sY1192-independent deletions was similar to that of other types of microdeletions, but the fertilization and cleavage rates were higher. We observed that eight deletion patterns were observed for sY1192 microdeletions of AZFb/c, dominated by the independent deletion of sY1192. After ICSI, the fertilization rate and cleavage rate of the sY1192-independent microdeletion were higher than those of other Y chromosome microdeletion types, but there was no significant difference in pregnancy outcomes.
Assessment of awareness level of sexually transmitted disease/reproductive tract infection (STI/RTI) among people visiting district STI/RTI clinic Chamba, H.P.
Authors: Singh Harinder , Raghuvanshi Vandna , Arora Lalit , Bansal Kuldeep , Arora Ishan 
Published: October 2024

ABSTRACT

Background:
Sexually transmitted infections (STIs) and reproductive tract infections (RTIs) are significant public health concerns with widespread implications for individuals and communities. This research article aims to evaluate the awareness and practices regarding STIs and RTIs among individuals attending an RTI/STI clinic in a tertiary care hospital.

Methodology:
It is a hospital-based observational study using a universal sampling technique. The study utilizes one-on-one interviews with patients visiting the district STI/RTI Clinic.

Results:
Out of 147 study participants, 94% were female, with a mean age of 32 years. Maximum patients were in the age group of 25–35 years. Most (82%) of the participants were aware of the symptom of abnormal vaginal discharge for STIs and RTIs but less aware of the other symptoms. Approximately 78% of the subjects were aware that unprotected sexual intercourse with an infected person causes STIs and RTIs. Health-seeking behavior was also good among the participants.

Conclusion:
In this study, it was found that a lot of patients were unaware of the different modes of transmission and various symptoms of STI/RTI due to which additional actions are required by policy makers as well as family physicians.