bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent fifth aortic arch: the “great pretender” in clinical practice
Authors: Lloyd David F. A. , Ho S. Y. , Pushparajah Kuberan , Chakraborty Subhasis , Nasser Mohamed , Uemura Hideki , Franklin Rodney , Magee Alan G. 
Published: August 2017

AbstractPersistence of the embryonic “fifth aortic arch” in postnatal life is a rare, enigmatic – and at times controversial – condition, with variable anatomical forms and physiological consequences. First described in humans over 40 years ago by Van Praagh, the condition was labelled the “great pretender” by Gerlis 25 years later, because of its apparent propensity to mimic anatomically similar structures. Despite many subsequent case reports citing the condition, the true developmental origin of these structures remains unresolved, and has been the subject of debate among embryologists for more than a century. A persistent fifth aortic arch has been defined as an extrapericardial structure, arising from the ascending aorta opposite or proximal to the brachiocephalic artery, and terminating in the dorsal aorta or pulmonary arteries via a persistently patent arterial duct. This description may therefore encompass various anatomical forms, such as a unilateral double-lumen aortic arch, an unrestrictive aortopulmonary shunt, or a critical vascular channel for either the systemic or pulmonary circulation. The physiological properties of these vessels, such as their response to prostaglandins, may also be unpredictable. In this article, we demonstrate a number of cases that fulfil the contemporary definition of “persistent fifth aortic arch” while acknowledging the embryological controversies associated with this term. We also outline the key diagnostic features, particularly with respect to the use of new cross-sectional imaging techniques.
Maternal pre-pregnancy BMI and offspring body composition in young adulthood: the modifying role of offspring sex and birth order
Authors: Chaparro M Pia , Koupil Ilona , Byberg Liisa 
Published: August 2017

AbstractObjectiveTo investigate if the association between maternal pre-pregnancy BMI and offspring’s body composition in late adolescence and young adulthood varies by offspring birth order and sex.DesignFamily cohort study, with data from registers, questionnaires and physical examinations. The main outcome under study was offspring body composition (percentage fat mass (%FM), percentage lean mass (%LM)) measured by dual-energy X-ray absorptiometry.SettingUppsala, Sweden.SubjectsTwo hundred and twenty-six siblings (first-born v. second-born; average age 19 and 21 years) and their mothers.ResultsIn multivariable linear regression models, maternal pre-pregnancy BMI was positively associated with daughter’s %FM, with stronger estimates for first-born (β=0·97, 95 % CI 0·14, 1·80) v. second-born daughters (β=0·64, 95 % CI 0·08, 1·20). Mother’s BMI before her first pregnancy was associated with her second-born daughter’s body composition (β=1·05, 95 % CI 0·31, 1·79 (%FM)) Similar results albeit in the opposite direction were observed for %LM. No significant associations were found between pre-pregnancy BMI and %FM (β=0·59, 95 % CI−0·27, 1·44 first-born; β=−0·13, 95 % CI−0·77, 0·52 second-born) or %LM (β=−0·54, 95 % CI−1·37, 0·28 first-born; β=0·11, 95 % CI−0·52, 0·74 second-born) for sons.ConclusionsA higher pre-pregnancy BMI was associated with higher offspring %FM and lower offspring %LM in late adolescence and young adulthood, with stronger associations for first-born daughters. Preventing obesity at the start of women’s reproductive life might reduce the risk of obesity in her offspring, particularly for daughters.
Computing LPMLN using ASP and MLN solvers
Authors: LEE JOOHYUNG , TALSANIA SAMIDH , WANG YI 
Published: August 2017

AbstractLPMLN is a recent addition to probabilistic logic programming languages. Its main idea is to overcome the rigid nature of the stable model semantics by assigning a weight to each rule in a way similar to Markov Logic is defined. We present two implementations of LPMLN, lpmln2asp and lpmln2mln. System lpmln2asp translates LPMLN programs into the input language of answer set solver clingo, and using weak constraints and stable model enumeration, it can compute most probable stable models as well as exact conditional and marginal probabilities. System lpmln2mln translates LPMLN programs into the input language of Markov Logic solvers, such as alchemy, tuffy, and rockit, and allows for performing approximate probabilistic inference on LPMLN programs. We also demonstrate the usefulness of the LPMLN systems for computing other languages, such as ProbLog and Pearl's Causal Models, that are shown to be translatable into LPMLN.
WILLIAM BATES AND HISCONCERTOS IN TEN PARTS, OP. 2: AN ENTERPRISING EIGHTEENTH-CENTURY COMPOSER AND AN UNRECOGNIZED ORCHESTRAL SUBGENRE EMPLOYING HORNS
Authors: TALBOT MICHAEL 
Published: August 2017

ABSTRACTWilliam Bates, who died in 1778, was a prolific and, in his day, successful composer of stage music and concert songs performed in London in the 1760s and 1770s; but a scarcity of biographical information and uncertainties over his position vis-à-vis the new style introduced in the early 1760s by J. C. Bach and others have tended to disadvantage him in modern commentary. New facts about his life and background together with a recently discovered sale catalogue reveal him to have been a cultivated man of wide interests, with a sympathy for the ‘ancient’ style. His most substantial musical contribution, as regards its potential for modern revival, is a remarkable set of six concertos for strings with oboes, bassoons and horns (plus, in two concertos, trumpets and timpani) published in 1762. These concertos, related in style to contemporary overtures to stage works but making much greater use of concertante writing, form a high point in a peculiarly British tradition of concertos employing French horns. The cult of the horn in Georgian Britain that nourished this tradition is the subject of extended discussion.
Adapting as usual: integrative and segregative institutions shaping adaptation to climate change in local public administrations
Authors: ROGGERO MATTEO , THIEL ANDREAS 
Published: August 2017

AbstractLocal administrations play a key role in delivering adaptation to climate change. To do so, they need to address collective action. Based on transaction costs economics, this paper explores the role of so-called integrative and segregative institutions in the way local administrations adapt – whether their different functional branches respond to climate change collectively rather than independently. Through a comparative analysis of 19 climate-sensitive local administrations in Germany, the paper shows that variation in the way local administrations structure their internal coordination determines the way they approach climate adaptation. Under integrative institutions, local administrations adjust prior coordination structures to accommodate adaptation. Under segregative institutions, administrations move towards integrative institutions in order to adapt, provided they already ‘feel’ climate change.
Unpredictability of escape trajectory explains predator evasion ability and microhabitat preference of desert rodents
Authors: Moore Talia Y. , Cooper Kimberly L. , Biewener Andrew A. , Vasudevan Ramanarayan 
Published: August 2017

AbstractMechanistically linking movement behaviors and ecology is key to understanding the adaptive evolution of locomotion. Predator evasion, a behavior that enhances fitness, may depend upon short bursts or complex patterns of locomotion. However, such movements are poorly characterized by existing biomechanical metrics. We present methods based on the entropy measure of randomness from Information Theory to quantitatively characterize the unpredictability of non-steady-state locomotion. We then apply the method by examining sympatric rodent species whose escape trajectories differ in dimensionality. Unlike the speed-regulated gait use of cursorial animals to enhance locomotor economy, bipedal jerboa (family Dipodidae) gait transitions likely enhance maneuverability. In field-based observations, jerboa trajectories are significantly less predictable than those of quadrupedal rodents, likely increasing predator evasion ability. Consistent with this hypothesis, jerboas exhibit lower anxiety in open fields than quadrupedal rodents, a behavior that varies inversely with predator evasion ability. Our unpredictability metric expands the scope of quantitative biomechanical studies to include non-steady-state locomotion in a variety of evolutionary and ecologically significant contexts.
The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are itinerant, not resident proteins of dendritic endosomes
Authors: Yap Chan Choo , Digilio Laura , McMahon Lloyd , Winckler Bettina 
Published: August 2017

AbstractMembrane traffic critically regulates most aspects of neuronal function. Neurons express many neuronal-specific proteins that regulate membrane traffic, including the poorly understood small transmembrane proteins neural-specific gene 1 and 2 (Nsg1/NEEP21 and Nsg2/P19). Nsg1 has been implicated in regulating endosomal recycling and sorting of several important neuronal receptors. Nsg2 is largely unstudied. At steady-state, Nsg1 and Nsg2 only partially co-localize with known endosomal compartments, and it was suggested that they mark a neuronal-specific endosome. Since Nsg1 localizes to and functions in the dendritic endosome, we set out to discover how Nsg1 and Nsg2 localization to endosomes is regulated in primary rat hippocampal neurons, using quadruple immunolocalization against endogenous proteins, live imaging of dendritic endosomes, and interference approaches against the endosomal regulators Rab5 and Rab7. In contrast to previous conclusions, we now show that Nsg1 and Nsg2 are not resident endosomal proteins, but traffic rapidly from the cell surface to lysosomes and have a half-life of less than two hours. Their partial co-localization with canonical endosomal markers thus reflects their rapid flux towards degradation rather than specific targeting to a singular compartment. These findings will require rethinking of how this class of endosomal proteins regulates trafficking of much longer-lived receptors.
Cytocompatible Anti-microbial Dressings of Syzygium cumini Cellulose Nanocrystals Decorated with Silver Nanoparticles Accelerate Acute and Diabetic Wound Healing
Authors: Singla Rubbel , Soni Sourabh , Patial Vikram , Kulurkar Pankaj Markand , Kumari Avnesh , S. Mahesh , Padwad Yogendra S. , Yadav Sudesh Kumar 
Published: August 2017

AbstractThe ever increasing incidences of non-healing skin wounds have paved way for many efforts on the convoluted process of wound healing. Unfortunately, the lack of relevance and success of modern wound dressings in healing of acute and diabetic wounds still remains a matter of huge concern. Here, an in situ three step approach was embraced for the development of nanocomposite (NCs) dressings by impregnating silver nanoparticles (AgNPs) onto a matrix of cellulose nanocrystals (CNCs) isolated from Syzygium cumini leaves using an environmental friendly approach. Topical application of NCs (ointments and strips) on acute and diabetic wounds of mice documented enhanced tissue repair (~99% wound closure) via decrease in inflammation; increase in angiogenesis, collagen deposition, and rate of neo-epithelialization that ultimately led to formation of aesthetically sound skin in lesser time than controls. Due to the synergistic action of CNCs (having high water uptake capacity) and AgNPs (anti-microbial agents), NCs tend to increase the expression of essential growth factors (FGF, PDGF and VEGF) and collagen while decreasing the pro-inflammatory factors (IL-6 and TNF-α) at the same time, thus accelerating healing. The results suggested the potential of these developed anti-microbial, cytocompatible and nanoporous NCs having optimized AgNPs concentration as ideal dressings for effective wound management.
2,4-D attenuates salinity-induced toxicity by mediating anatomical changes, antioxidant capacity and cation transporters in the roots of rice cultivars
Authors: Islam Faisal , Farooq Muhammad A. , Gill Rafaqat A. , Wang Jian , Yang Chong , Ali Basharat , Wang Guang-Xi , Zhou Weijun 
Published: August 2017

AbstractGrowth regulator herbicides are widely used in paddy fields to control weeds, however their role in conferring environmental stress tolerance in the crop plants are still elusive. In this study, the effects of recommended dose of 2,4-dichlorophenoxyacetic acid (2,4-D) on growth, oxidative damage, antioxidant defense, regulation of cation transporter genes and anatomical changes in the roots of rice cultivars XS 134 (salt resistant) and ZJ 88 (salt sensitive) were investigated under different levels of saline stress. Individual treatments of saline stress and 2,4-D application induced oxidative damage as evidenced by decreased root growth, enhanced ROS production, more membrane damage and Na+ accumulation in sensitive cultivar compared to the tolerant cultivar. Conversely, combined treatments of 2,4-D and saline stress significantly alleviated the growth inhibition and oxidative stress in roots of rice cultivars by modulating lignin and callose deposition, redox states of AsA, GSH, and related enzyme activities involved in the antioxidant defense system. The expression analysis of nine cation transporter genes showed altered and differential gene expression in salt-stressed roots of sensitive and resistant cultivars. Together, these results suggest that 2,4-D differentially regulates the Na+ and K+ levels, ROS production, antioxidant defense, anatomical changes and cation transporters/genes in roots of rice cultivars.
Targeted error-suppressed quantification of circulating tumor DNA using semi-degenerate barcoded adapters and biotinylated baits
Authors: Alcaide Miguel , Yu Stephen , Davidson Jordan , Albuquerque Marco , Bushell Kevin , Fornika Daniel , Arthur Sarah , Grande Bruno M. , McNamara Suzan , Tertre Mathilde Couetoux du , Batist Gerald , Huntsman David G. , Cavallone Luca , Aguilar Adriana , Basik Mark , Johnson Nathalie A. , Deyell Rebecca J. , Rassekh S. Rod , Morin Ryan D. 
Published: August 2017

AbstractUltrasensitive methods for rare allele detection are critical to leverage the full potential offered by liquid biopsies. Here, we describe a novel molecular barcoding method for the precise detection and quantification of circulating tumor DNA (ctDNA). The major benefits of our design include straightforward and cost-effective production of barcoded adapters to tag individual DNA molecules before PCR and sequencing, and better control over cross-contamination between experiments. We validated our approach in a cohort of 24 patients with a broad spectrum of cancer diagnoses by targeting and quantifying single-nucleotide variants (SNVs), indels and genomic rearrangements in plasma samples. By using personalized panels targeting a priori known mutations, we demonstrate comprehensive error-suppression capabilities for SNVs and detection thresholds for ctDNA below 0.1%. We also show that our semi-degenerate barcoded adapters hold promise for noninvasive genotyping in the absence of tumor biopsies and monitoring of minimal residual disease in longitudinal plasma samples. The benefits demonstrated here include broad applicability, flexibility, affordability and reproducibility in the research and clinical settings.
Comparative transcriptome analysis of the Pacific White Shrimp (Litopenaeus vannamei) muscle reveals the molecular basis of residual feed intake
Authors: Dai Ping , Luan Sheng , Lu Xia , Luo Kun , Kong Jie 
Published: August 2017

AbstractFeed efficiency is an economically important trait in genetic improvement programs ofL. vannamei. Residual feed intake (RFI), an ideal measure of feed efficiency, is the difference between observed feed intake and expected feed requirement predicted from maintenance and production. Exploring the molecular basis of RFI is essential to facilitate the genetic breeding of feed efficiency inL. vannamei. However, few studies have been reported in this aspect. In this study, we sequenced muscle transcriptomes of a high﻿-efficiency group, a low﻿-efficiency group and a control group originating from two families, and compared the gene expression patterns between each extreme group and the control group. A total of 383 differentially expressed genes were identified, most of which were involved in cell proliferation, growth and signaling, glucose homeostasis, energy and nutrients metabolism. Functional enrichment analysis of these genes revealed 13 significantly enriched biological pathways, including signaling pathways such as PI3K-Akt signaling pathway, AMPK signaling pathway and mTOR signaling pathway, as well as some important pathways such as ubiquitin mediated proteolysis, cell cycle, pentose phosphate pathway and glycolysis/gluconeogenesis. These genes and pathways provide initial insight into the molecular mechanisms driving the feed efficiency inL. vannamei.
Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation
Authors: You Chuangang , Li Qiong , Wang Xingang , Wu Pan , Ho Jon Kee , Jin Ronghua , Zhang Liping , Shao Huawei , Han Chunmao 
Published: August 2017

AbstractTreatment of full-thickness skin defects poses significant clinical challenges including risk of infection and severe scaring. Silver nanoparticle (NAg), an effective antimicrobial agent, has provided a promising therapeutic method for burn wounds. However, the detailed mechanism remains unknown. Hence, we constructed a metallic nanosilver particles-collagen/chitosan hybrid scaffold (NAg-CCS) and investigated its potential effects on wound healing. In vitro scratch assay, immunofluorescence staining and antibacterial activity of the scaffold were all studied. In vivo NAg-CCS was applied in full-thickness skin defects in Sprague-Dawley (SD) rats and the therapeutic effects of treatment were evaluated. The results showed that NAg at a concentration of 10 ppm accelerated the migration of fibroblasts with an increase in expression of α-smooth muscle actin (α-SMA). Furthermore, in vivo studies showed increased levels of pro-inflammatory and scar-related factors as well as α-SMA, while markers for macrophage activation were up-regulated. On day 60 post transplantation of ultra-thin skin graft, the regenerated skin by NAg-CCS had a similar structure to normal skin. In summary, we demonstrated that NAg-CCS was bactericidal, anti-inflammatory and promoted wound healing potentially by regulating fibroblast migration and macrophage activation, making it an ideal dermal substitute for wound regeneration.
Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability
Authors: Briston Thomas , Roberts Malcolm , Lewis Sian , Powney Ben , M. Staddon James , Szabadkai Gyorgy , Duchen Michael R. 
Published: August 2017

AbstractMitochondrial Ca2+ uptake has a key role in cellular Ca2+ homeostasis. Excessive matrix Ca2+ concentrations, especially when coincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conductance channel: the mitochondrial permeability transition pore (mPTP). mPTP opening has been implicated as a final cell death pathway in numerous diseases and therefore understanding conditions dictating mPTP opening is crucial for developing targeted therapies. Here, we have investigated the impact of mitochondrial metabolic state on the probability and consequences of mPTP opening. Isolated mitochondria were energised using NADH- or FADH2-linked substrates. The functional consequences of Ca2+-induced mPTP opening were assessed by Ca2+ retention capacity, using fluorescence-based analysis, and simultaneous measurements of mitochondrial Ca2+ handling, membrane potential, respiratory rate and production of reactive oxygen species (ROS). Succinate-induced, membrane potential-dependent reverse electron transfer sensitised mitochondria to mPTP opening. mPTP-induced depolarisation under succinate subsequently inhibited reverse electron transfer. Complex I-driven respiration was reduced after mPTP opening but sustained in the presence of complex II-linked substrates, consistent with inhibition of complex I-supported respiration by leakage of matrix NADH. Additionally, ROS generated at complex III did not sensitise mitochondria to mPTP opening. Thus, cellular metabolic fluxes and metabolic environment dictate mitochondrial functional response to Ca2+ overload.
Reconstructing complex network for characterizing the time-varying causality evolution behavior of multivariate time series
Authors: Jiang Meihui , Gao Xiangyun , An Haizhong , Li Huajiao , Sun Bowen 
Published: August 2017

AbstractIn order to explore the characteristics of the evolution behavior of the time-varying relationships between multivariate time series, this paper proposes an algorithm to transfer this evolution process to a complex network. We take the causality patterns as nodes and the succeeding sequence relations between patterns as edges. We used four time series as sample data. The results of the analysis reveal some statistical evidences that the causalities between time series is in a dynamic process. It implicates that stationary long-term causalities are not suitable for some special situations. Some short-term causalities that our model recognized can be referenced to the dynamic adjustment of the decisions. The results also show that weighted degree of the nodes obeys power law distribution. This implies that a few types of causality patterns play a major role in the process of the transition and that international crude oil market is statistically significantly not random. The clustering effect appears in the transition process and different clusters have different transition characteristics which provide probability information for predicting the evolution of the causality. The approach presents a potential to analyze multivariate time series and provides important information for investors and decision makers.
Remarkable plasticity of Na+, K+-ATPase, Ca2+-ATPase and SERCA contributes to muscle disuse atrophy resistance in hibernating Daurian ground squirrels
Authors: Guo Quanling , Mi Xin , Sun Xiaoyong , Li Xiaoyu , Fu Weiwei , Xu Shenhui , Wang Qi , Arfat Yasir , Wang Huiping , Chang Hui , Gao Yunfang 
Published: August 2017

AbstractWe investigated cytosolic calcium (Ca2+) and sarcoplasmic reticulum Ca2+ regulation in skeletal muscle fibers of hibernating Daurian ground squirrels (Spermophilus dauricus), non-hibernating hindlimb-unloaded (HLU) squirrels, and HLU rats to clarify the molecular mechanisms involved in preventing muscle atrophy in hibernators. The Na+, K+-ATPase and Ca2+-ATPase activities in the soleus muscle (SOL) of squirrels were maintained in hibernation, decreased during interbout arousal (IB-A), and increased to autumn/pre-hibernation (AUT/Pre-H) levels in torpor after interbout arousal (Post-IBA), whereas activities in the extensor digitorum longus muscle (EDL) were stable during hibernation, but increased during post-hibernation (Post-H). Activities increased in the SOL of HLU rats, but were stable in HLU squirrels. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity in the SOL decreased in IB-A squirrels, but returned to AUT/Pre-H levels in the Post-IBA group; no significant changes were found in the EDL. SERCA activity increased in the EDL of HLU squirrels and SOL of HLU rats. Compared with AUT/Pre-H, SERCA type 2 protein expression increased in the SOL and EDL of IB-A and Post-IBA squirrels, but increased in the SOL only in HLU animals. We also describe the protein kinase A changes in this paper. Thus, hibernating ground squirrels displayed remarkable Na+, K+-ATPase, Ca2+-ATPase, and SERCA plasticity.