bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Chronic Worrier
Authors: Rosewater Jacob , Newport D. Jeffrey 
Published: October 2024

Abstract
In this chapter, Ms. E, a 34-year-old woman, visits a clinic to establish care. She reveals a history of trouble sleeping, fatigue, difficulty concentrating, and muscle tension, along with frequent arguments with coworkers. These symptoms have persisted for several years, making her wonder if something is wrong with her. She also admits to excessive worry about various issues, and this presentation prompts consideration of generalized anxiety disorder (GAD). For the diagnosis of this condition, it is essential to distinguish pathological anxiety from normal worry, as GAD is characterized by pervasive, uncontrollable worry that causes distress and impairment. This chapter also discusses differential diagnoses, emphasizing the need to exclude anxiety stemming from mood or psychotic disorders. Treatment options include antidepressants and psychotherapy, primarily cognitive-behavioral therapy. The choice between medication and therapy depends on patient preference and symptom severity.
I’m Really Scared About the Pending Diagnosis: What If It’s Bad?
Authors: Velit Mario , Luca Luminita 
Published: October 2024

Abstract
This chapter introduces Mr. A, a 58-year-old man with multiple medical conditions, including chronic obstructive pulmonary disease and coronary artery disease, who is admitted to the hospital due to worsening respiratory symptoms. Mr. A is experiencing significant distress and anxiety related to his illness. This case illustrates the common occurrence of anxiety in medically ill patients, which can be triggered by uncertainty and the fear of the unknown. This chapter emphasizes the importance of distinguishing between anxiety as a reaction to illness and preexisting anxiety disorders. It discusses how anxiety symptoms can manifest both emotionally and physically, often overlapping with the symptoms of the underlying medical condition. This chapter highlights the need for a comprehensive assessment, including medical and psychiatric history, physical examination, and collaboration with the medical team to determine the cause of anxiety. It also notes that certain medications used to treat medical conditions can exacerbate anxiety symptoms.
Why Can’t I Stay Home Like During Online School?
Authors: Gross Lawrence , Poulsen Raul 
Published: October 2024

Abstract
The chapter discusses the case of a 9-year-old boy, GP, who is experiencing significant distress and anxiety related to separation from his mother. GP’s behavior has changed since he started in-person schooling and extracurricular activities, with frequent tantrums and distress when preparing to leave home. He expresses fear about his mother contracting COVID and often complains of abdominal discomfort. His mother admits to being overly cautious and keeping him home during pandemic outbreaks and playdates. GP’s symptoms fit the criteria for separation anxiety disorder (SA), a common childhood anxiety disorder. This chapter highlights that SA can emerge after stressful life circumstances. SA often presents with various symptoms related to separation. It can also co-occur with other psychiatric conditions. The importance of careful evaluation to distinguish SA from other conditions is discussed, and treatment options are presented. This chapter provides valuable insights into the diagnosis and management of SA in children.
Electronic Publishing
Authors: Berkwits Michael 
Published: October 2024

Abstract
Electronic publishing and distribution of medical science have become a community and cultural standard and are characterized by rapid change and ever-increasing complexity. This chapter recommends that authors of scientific manuscripts and journals consider the online ecosystem, specifically social media, multimedia, search, and free vs open access, as they develop their scientific reports and grow their websites to help ensure their science is discoverable and to enhance the dissemination of content efficiently and effectively.
Avoiding Spin and Boasting in Scientific Writing
Authors: Rivara Frederick P. 
Published: October 2024

Abstract
Scientific writing should be objective, clear, and dispassionate. This chapter describes approaches for achieving objectivity in writing and avoiding spin and boasting in scientific manuscripts. Pitfalls to avoid when writing include exaggerating the importance of the topic of the manuscript; unfairly disparaging previous research by using terminology such as “inconsistent” or “mixed” results, “methodologic flaws,” and “retrospective”; criticizing studies with small sample sizes; using words to convince, not illuminate, rather than presenting the evidence in a clear, concise, and unambiguous manner; and boasting or overemphasizing the primacy or importance of the findings reported in the manuscript. Other guidance includes avoiding making cliché statements, editorializing about results, and imparting spin, as well as encouraging reading examples of good scientific writing.
Brief Reports and Research Letters
Authors: Zylke Jody W. 
Published: October 2024

Abstract
Short research articles, which may be called Brief Reports or Research Letters, are reports of original data, and benefit from being concise, focused, and easy to read. This chapter discusses brief research reports, which are similar to but shorter than full-length research articles, and Research Letters, which vary in format from journal to journal. These short research reports may address specific topics that can be provocative or creative and may represent an opportunity for an author to have work published in a high-profile journal. This chapter also provides guidance for authors to help determine whether to consider writing a brief report or research letter, and describes the structure, format, and requirements of both.
Reviewing Manuscripts for Peer-Reviewed Journals
Authors: Rivara Frederick P. 
Published: October 2024

Abstract
Even though nearly all scientific journals rely on peer reviewers to evaluate manuscripts, most reviewers are rarely given any advice, by their senior colleagues or others, on how best to peer review manuscripts. This chapter provides that advice and suggestions to help ensure that reviewers prepare a manuscript review that will be helpful to authors and editors. The chapter also discusses a general approach to the process of reviewing and the more specific parts of each manuscript that reviewers should evaluate, including posing specific questions they can answer for each. Suggestions also are provided for presenting comments to the editor and detailed comments to the authors, how to keep a review timely, and how reviewers should address their potential conflicts of interest.
Authorship Criteria and Ethical Aspects
Authors: Fontanarosa Phil B. , Bauchner Howard , Flanagin Annette 
Published: October 2024

Abstract
Authors of scientific publications must adhere to the principles and standards to ensure the necessary accountability and responsibility for the work being reported. This chapter reviews the important topic of authorship of articles in scientific journals and recommends that before preparing a manuscript, all individuals who are being considered for inclusion as authors should prospectively agree on the roles and responsibilities each person will have in writing the manuscript and making other contributions, including the position in the author byline. Concerns related to honorary and ghost authors also are addressed, along with options for designating authorship and shared author responsibilities. The role of the corresponding author is explained, and suggestions are provided for addressing changes in authorship and disagreements among authors after manuscript submission. The accountability of each author for the validity, veracity, and integrity of the information reported and the importance of meeting authorship criteria are discussed.
OmicsFootPrint: a framework to integrate and interpret multi-omics data using circular images and deep neural networks
Authors: Tang Xiaojia , Prodduturi Naresh , Thompson Kevin J , Weinshilboum Richard , O’Sullivan Ciara C , Boughey Judy C , Tizhoosh Hamid R , Klee Eric W , Wang Liewei , Goetz Matthew P , Suman Vera , Kalari Krishna R 
Published: October 2024

Abstract
The OmicsFootPrint framework addresses the need for advanced multi-omics data analysis methodologies by transforming data into intuitive two-dimensional circular images and facilitating the interpretation of complex diseases. Utilizing deep neural networks and incorporating the SHapley Additive exPlanations algorithm, the framework enhances model interpretability. Tested with The Cancer Genome Atlas data, OmicsFootPrint effectively classified lung and breast cancer subtypes, achieving high area under the curve (AUC) scores—0.98 ± 0.02 for lung cancer subtype differentiation and 0.83 ± 0.07 for breast cancer PAM50 subtypes, and successfully distinguished between invasive lobular and ductal carcinomas in breast cancer, showcasing its robustness. It also demonstrated notable performance in predicting drug responses in cancer cell lines, with a median AUC of 0.74, surpassing nine existing methods. Furthermore, its effectiveness persists even with reduced training sample sizes. OmicsFootPrint marks an enhancement in multi-omics research, offering a novel, efficient and interpretable approach that contributes to a deeper understanding of disease mechanisms.
PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling
Authors: Yang Yang , Jayaprakash Deepika , Jhujh Satpal S , Reynolds John J , Chen Steve , Gao Yanzhe , Anand Jay Ramanlal , Mutter-Rottmayer Elizabeth , Ariel Pablo , An Jing , Cheng Xing , Pearce Kenneth H , Blanchet Sophie-Anne , Nandakumar Nandana , Zhou Pei , Fradet-Turcotte Amélie , Stewart Grant S , Vaziri Cyrus 
Published: October 2024

Abstract
RNF168 orchestrates a ubiquitin-dependent DNA damage response to regulate the recruitment of repair factors, such as 53BP1 to DNA double-strand breaks (DSBs). In addition to its canonical functions in DSB signaling, RNF168 may facilitate DNA replication fork progression. However, the precise role of RNF168 in DNA replication remains unclear. Here, we demonstrate that RNF168 is recruited to DNA replication factories in a manner that is independent of the canonical DSB response pathway regulated by Ataxia-Telangiectasia Mutated (ATM) and RNF8. We identify a degenerate Proliferating Cell Nuclear Antigen (PCNA)-interacting peptide (DPIP) motif in the C-terminus of RNF168, which together with its Motif Interacting with Ubiquitin (MIU) domain mediates binding to mono-ubiquitylated PCNA at replication factories. An RNF168 mutant harboring inactivating substitutions in its DPIP box and MIU1 domain (termed RNF168 ΔDPIP/ΔMIU1) is not recruited to sites of DNA synthesis and fails to support ongoing DNA replication. Notably, the PCNA interaction-deficient RNF168 ΔDPIP/ΔMIU1 mutant fully rescues the ability of RNF168−/− cells to form 53BP1 foci in response to DNA DSBs. Therefore, RNF168 functions in DNA replication and DSB signaling are fully separable. Our results define a new mechanism by which RNF168 promotes DNA replication independently of its canonical functions in DSB signaling.
Association of perinatal exposition to xenobiotics with kidney volume at birth
Authors: De Santiago-Rodríguez Katy Valeria , Peregrina-Lucano Alejandro Aarón , Jaramillo-Arriaga Fernando , Helguera-Gomez Emmanuel Oziel , Ibarra-Orenday Daniel , González-Domínguez Salomón Israel , Ramirez Sandoval Elizabeth , Macias Duron Emmanuel Salomon , Enriquez Muñoz Eduardo Alfredo , Hernandez Rocha Juan Fernando , Rangel Talamantes Julio Cesar , Martinez Medina Tayde Selene , Reyes Gonzalez Octavio Daniel , del Carmen Corrales-Aguirre Myriam , Sánchez-Ortiz María del Rosario , Camarillo-Contreras Omar Oswaldo , Chew-Wong Alfredo , Ramos-Medellín Carmen Lucrecia , Zuñiga-Macias Leslie Paola , Flores Amaro Oscar Abraham , Yamamoto Flores Laura , Guerrero Barrera Alma Lilian , Avelar-González Francisco Javier , Arreola-Guerra José Manuel 
Published: October 2024

ABSTRACT

Background
The state of Aguascalientes has the highest prevalence of kidney failure in young adults globally. A low nephron endowment has been suggested as a possible aetiology. This study aims to evaluate the association between exposure to xenobiotics and low kidney volume (KV) at birth.

Methods
This is a cross-sectional, observational, descriptive study of at-term pregnant women with no comorbidities. We collected the mother’s urine (MU) and amniotic fluid (AF) and the neonate’s urine (NU). Metals and non-metals were measured with inductively coupled plasma mass spectrometry, pesticides with high-performance liquid chromatography and fluoride with ion-selective potentiometry. The total KV adjusted by body surface area (TKVBS) was calculated based on the kidney ultrasound.

Results
Between March 2022 and July 2023, we included 299 women with an average age of 24.2 years [standard deviation (SD) 5.1]. A total of 54.2% of neonates were male with an average weight of 3266 g (SD 399). Factors associated with TKVBS ≤5th percentile were female sex, weight gain during pregnancy, glomerular filtration rate, methomyl concentration in AF {odds ratio [OR] 7.41 [95% confidence interval (CI) 2.31–23.8], P = .001}, 2,4-dichlorophenoxyacetic (2,4-D) &gt;10 ng/ml in AF [OR 4.99 (95% CI 1.58–15.7), P = .002], MU [OR 6.1 (95% CI 1.9–19.7), P = 0.002] and NU [OR 5.1 (95% CI 1.10–26.2), P = .023] and fluoride in MU [OR 5.1 (95% CI 1.10–23.5), P = .010] and AF [OR 6.76 (95% CI 1.28–35.7), P = .024]. In all matrices (MU, AF and NU), exposure to pesticides was also significantly associated with greater concentrations of electrolytes (sodium, potassium, calcium, phosphate and magnesium) and trace elements (zinc and iron).

Conclusions
In neonates born to at-term women with no comorbidities, the presence of pesticides and fluoride was associated with low KV. The significant loss of electrolytes and trace elements associated with pesticides suggests proximal tubulopathy.
Glutamate dehydrogenase 1-catalytic glutaminolysis feedback activates EGFR/PI3K/AKT pathway and reprograms glioblastoma metabolism
Authors: Yang Rui , Zhang Guanghui , Meng Zhen , Wang Li , Li Yanping , Li Haibin , Yan Siyuan , Wei Xiaonan , Wang Shanshan , Cui Hongjuan 
Published: October 2024

Abstract

Background
Glutamine is an important nutrient for cancer cell growth that provides biological sources for nucleic acid and fatty acid synthesis, but the role of glutaminolysis in signal transduction and glioblastoma (GBM) progression remains little known.

Methods
Knockdown and overexpression cells were obtained to explore the functional roles of glutamate dehydrogenase 1 (GDH1) in cell proliferation, tumor formation, and aerobic glycolysis. RNA-seq, Chromatin immunoprecipitation, luciferase assay, and western blot were performed to verify the regulation of the EGFR-AKT pathway by the GDH1 (also known as GLUD1) and KDM6A. Metabolite-level measurements and Seahorse Assay were performed to assess the functional role of GHD1 in reprogramming glycolysis.

Results
Here, we report that GDH1 catalytic glutaminolysis is essential for GBM cell line proliferation and brain tumorigenesis even in high-glucose conditions. Glutamine is metabolized through glutaminolysis to produce α-ketoglutarate (α-KG). We demonstrate that glutamine in combination with leucine activates mammalian TORC1 by enhancing glutaminolysis and α-KG production. α-KG increases the transcription of PDPK1 by reducing the suppressive histone modification H3K27me3 and then promotes the activation of the PI3K/AKT/mTOR pathway. This transcriptional activation induced by α-KG requires histone demethylase KDM6A, which is a 2-oxoglutarate oxygenase that plays an important role in converting α-KG to succinate. Furthermore, we show that GDH1-catalytic glutaminolysis also increases the expression of HK2 and promotes glycolysis in high-glucose conditions dependent on KDM6A-mediated demethylation of H3K27.

Conclusions
These findings suggest a novel function of glutaminolysis in the regulation of signal transduction and metabolism reprogramming and provide further evidence for the unique role of glutaminolysis in GBM progression.
Warm-adapted encroachment outpaces cool-adapted retreat in a hotspot of trailing-edge population diversity in the southern Appalachian Mountains, USA
Authors: Gaya Heather E , Chandler Richard B 
Published: October 2024

ABSTRACT
Many populations near receding low-latitude range: margins are declining in response to climate change, but most studies of trailing-edge populations have focused on single species. Using 10 years (2014–2023) of avian survey data from a high-elevation trailing-edge population hotspot in the Appalachian Mountains, USA, we tested the hypothesis that high-elevation communities would experience turnover through thermophilization, as warm-adapted species near the center of their geographic ranges expand into regions formerly dominated by peripheral populations of cool-adapted species. Three of the nine cool-adapted, peripheral populations decreased in abundance, and whereas 6 species exhibited little change. For warm-adapted populations near the core of their range, 1 of 16 decreased in abundance, 11 increased, and 4 exhibited no change. Within the most abundant species in this community, our results indicate that warm-adapted species are expanding their ranges faster than the rate at which ranges of cool-adapted species are contracting. Avoiding future community turnover may require conservation strategies that maintain microclimates for cool-adapted species facing novel abiotic and biotic conditions at high elevations.
Capital Connections
Authors: Thompson Gordon Ross 
Published: October 2024

Abstract
Living and performing in and around London offered strategic advantages for musicians over those coming from cities like Liverpool and Manchester. Not only were there more venues in which to perform, but access to recording studios and to major music news outlets proved invaluable. Southern performers responded to the success of northern groups both by imitating what they heard and by developing their own versions of British pop. The dance halls where they played shaped their music and were managed by organizations such as Mecca Dance Ltd. whose business model of class equity reflected an important postwar social goal. The program Ready Steady Go! drew directly from London dance halls and clubs and featured local bands, such as Brian Poole and the Tremeloes and the Dave Clark Five, whose music responded directly to audiences with dance-friendly music.
Old Bottles, New Wine
Authors: Thompson Gordon Ross 
Published: October 2024

Abstract
The sixties saw many musicians overlaying new ideas onto American originals to create British rhythm-and-blues (BRB). Joe Boyd arrived in London to set up offices for Elektra Records and to search for British talent to record for American audiences. He oversaw the temporary collaboration of Eric Clapton, Steve Winwood, and others as Powerhouse to showcase British electric blues talent in comparison to its American counterparts. Winwood would soon have his own success by applying new lyrics to the chords and grooves of existing blues and jazz tunes. The Yardbirds began developing their own material by taking advantage of guitarist Jeff Beck’s inventive skills. Perhaps the most famous pop-blues band of the era, however, Cream came about when Eric Clapton, Jack Bruce, and Ginger Baker elevated virtuosity as a component of British rhythm-and-blues. Soon British guitar virtuosos such as Jeff Beck and Alvin Lee were redefining the genre.
Inventing a Soviet Russian Popular Culture Icon The Context and Origins of Seventeen Moments
Authors: Amar Tarik Cyril 
Published: October 2024

Abstract
Chapter 3 explores the origins and massive success of the Soviet television series Seventeen Moments of Spring. It details the twelve-part structure of this series and summarizes its complex plot and explains the relationship between writer Iulian Semionov’s original novel and the series as directed by Tatiana Lioznova for the Gorky Studio in Moscow. The chapter sketches the qualities of the Shtirlits superspy character, as developed specifically in “Seventeen Moments” and its great popularity in Soviet and Russian popular culture. The making and success of the show is put in the context of comparable Soviet productions for cinema and television, such as The Shield and the Sword. It also addresses a deliberate KGB public relations policy and the Soviet and specifically Russian memory of the “Great Fatherland War” between Nazi Germany and the Soviet Union and the marginalization of the memory of the Holocaust.
From Stained Glass to Passion Plays
Authors: Peppard Michael 
Published: October 2024

Abstract
This chapter shows how the Catholic artistic reception of the biblical story also emphasized the suffering of the ruler, as the Passion narrative moved to center stage in the medieval era. The Bible of medieval Catholic art dwells on the paradox of Jesus: the universal ruler from birth who becomes the model of humble, pious pain. From the three “kings” to the “crown” of thorns, from a near-absent cross to a grisly, ever-present crucifix, from a pious Virgin Mary to a forlorn Mary Magdalene: the centuries of medieval Catholic imagination largely created the dominant motifs of biblical visualization for later eras of Catholicism. This chapter gives special attention to the biblical interpretations expressed through veneration of the Virgin Mary in diverse guises, alongside surprising shifts in the characterization of Mary Magdalene over time. Through it all, the reflexive relationship between the textual and artistic receptions of the Catholic Bible can be demonstrated, whether through glass, sculpture, painting, pilgrimage artifacts, or the drama of Passion Plays.
Tolkien on Chaucer, 1913-1959
Authors: Bowers John M. , Steffensen Peter 
Published: October 2024

Abstract
This book makes available J. R. R. Tolkien’s career-long writings on Chaucer from his 1913 undergraduate essay on the poet’s language to his 1959 retirement lecture about the medieval poet’s place on the Oxford English syllabus. It includes annotated versions of his landmark 1934 article “Chaucer as a Philologist: The Reeve’s Tale” and his late Chaucer-inspired piece “Middle English Losenger” originally published in 1953. Early work with the Oxford English Dictionary introduced him to the range of Chaucer editions. Published for the first time here are commentaries from his unpublished Clarendon edition Selections from Chaucer’s Poetry and Prose, his study “Chaucer and the Alliterative Tradition”, his 1947 lecture to the Oxford Dante Society, some newly discovered letters about Chaucer, and his experimental edition of the Reeve’s Tale produced for Oxford’s Summer Diversions in 1939 and then expanded for teaching Navy cadets in 1944. Selections are included from his Oxford lectures on the Clerk’s Tale and the Parlement of Foules after he became Merton Professor in 1945. A complete transcription of his late lecture The Pardoner’s Tale: The Story and Its Form shows Tolkien’s realization that he had told much the same story of men fighting to the death over a gold treasure at the core of The Lord of the Rings. The book makes these steady connections between Tolkien’s Chaucerian writings and his fantasy novels.