bluuebunny/crossref_metadata_2025_split huggingface dataset:
The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders
Authors: Rajkumar Anto P. , Qvist Per , Larsen Sanne H. , Lazarus Ross , Pallesen Jonatan , Nava Nicoletta , Winther Gudrun , Liebenberg Nico , Paternoster Veerle , Fryland Tue , Palmfeldt Johan , Fejgin Kim , Mørk Arne , Nyegaard Mette , Pakkenberg Bente , Didriksen Michael , Nyengaard Jens R. , Wegener Gregers , Mors Ole , Christensen Jane H. , Børglum Anders D. 
Published: February 2018

AbstractThe schizophrenia and bipolar disorder associated gene, BRD1, encodes a scaffold protein that in complex with epigenetic modifiers regulate gene sets enriched for psychiatric disorder risk. Preclinical evidence from male Brd1+/− mice has previously implicated BRD1 with phenotypes of translational relevance to schizophrenia. Here we describe the phenotype of female Brd1+/− mice and report attenuated dendritic architecture and monoaminergic dysregulation accompanied by sex-specific changes in affective behaviors. In accordance, global gene expression profiling reveals regional dysregulation of gene sets enriched with major depressive disorder and schizophrenia risk in female and male Brd1+/− mice, respectively. Independent of sex, however, differentially expressed genes cluster in common functional pathways associated with psychiatric disorders, including mitochondrial dysfunction and oxidative phosphorylation as well as G-protein coupled-, and nuclear receptor mediated signaling. Accordingly, we provide in vitro evidence that BRD1 modulates the transcriptional drive of a subset of nuclear receptors (e.g. the vitamin D and glucocorticoid receptors). Moreover, we demonstrate enrichment of psychiatric disorder risk in the target genes of nuclear receptors, sex-biased expression of several nuclear receptor genes in the adult brain of Brd1+/− mice, and that sex-biased genes in general are enriched with nuclear receptor genes particularly at the earliest developmental stage of the human brain. Overall, our data suggests that the spatio-temporal interaction between BRD1 and subsets of nuclear receptors in the brain is sex-biased and that hampered BRD1 mediated regulation of target genes governed by certain nuclear receptors may significantly contribute to sex differences in psychopathology.
A bacterial growth law out of steady-state
Authors: Kohanim Yael Korem , Levi Dikla , Jona Ghil , Bren Anat , Alon Uri 
Published: February 2018

SummaryBacterial growth depends on numerous reactions, and yet follows surprisingly simple laws that inspired biologists for decades. Growth laws until now primarily dealt with steady-state exponential growth in constant conditions. However, bacteria in nature often face fluctuating environments, with nutritional upshifts and downshifts. We therefore ask whether there are growth laws that apply to changing environments. We derive a law for strong upshifts using an optimal resource-allocation model that was previously calibrated at steady-state growth: the post-shift growth rate equals the geometrical mean of the pre-shift growth rate and the growth rate on saturating carbon. We test this using chemostat and robotic batch culture experiments, as well as previous data from several species, and find good agreement with the model predictions. The increase in growth rate after an upshift indicates that ribosomes have spare capacity. We demonstrate theoretically that spare ribosomal capacity has the cost of slow steady-state growth, but is beneficial in fluctuating environments because it prevents large overshoots in intracellular metabolites after an upshift and allows rapid response to change. We also provide predictions for downshifts for future experimental tests. Spare capacity appears in diverse biological systems, and the present study quantifies the optimal degree of spare capacity, which rises the slower the growth rate, and suggests that it can be precisely regulated.
Visualizing structure-mediated interactions in supercoiled DNA molecules
Authors: Scott Shane , Xu Zhi Ming , Kouzine Fedor , Berard Daniel J. , Shaheen Cynthia , Gravel Barbara , Saunders Laura , Hofkirchner Alexander , Leroux Catherine , Laurin Jill , Levens David , Benham Craig J. , Leslie Sabrina R. 
Published: February 2018

ABSTRACTWe directly visualize the topology-mediated interactions between an unwinding site on a supercoiled DNA plasmid and a specific probe molecule designed to bind to this site, as a function of DNA supercoiling and temperature. The visualization relies on containing the DNA molecules within an enclosed array of glass nanopits using the Convex Lens-induced Confinement (CLiC) imaging method. This method traps molecules within the focal plane while excluding signal from out-of-focus probes. Simultaneously, the molecules can freely diffuse within the nanopits, allowing for accurate measurements of exchange rates, unlike other methods which could introduce an artifactual bias in measurements of binding kinetics. We demonstrate that the plasmid’s structure influences the binding of the fluorescent probes to the unwinding site through the presence, or lack, of other secondary structures. With this method, we observe an increase in the binding rate of the fluorescent probe to the unwinding site with increasing temperature and negative supercoiling. This increase in binding is consistent with the results of our numerical simulations of the probability of site-unwinding. The temperature dependence of the binding rate has allowed us to distinguish the effects of competing higher order DNA structures, such as Z-DNA, in modulating local site-unwinding, and therefore binding.
Business intelligence and competitiveness: the mediating role of entrepreneurial orientation
Authors: Caseiro Nuno , Coelho Arnaldo 
Published: February 2018

Purpose
This study aims to investigate the influence of business intelligence (BI) in startups competitiveness, contributing to a gap in literature as this relationship is normally more focused on stablished businesses. The mediating role of entrepreneurial orientation (EO) was taken in to account in the proposed research model.

Design/methodology/approach
The model was tested using structural equation modeling. A total of 228 valid questionnaires were collected from a research sample comprised of incubated startups from several European countries.

Findings
The results point to significant mediating role of EO in the impact of BI on competitiveness. The direct impact of BI on competitiveness was not confirmed.

Research limitations/implications
The results highlight the importance that BI can have in startups competitiveness, namely, reinforcing the role of pro-activeness, innovativeness and risk taking – the traditional dimensions of EO, providing the information needed for more supported decisions.

Originality/value
Although there are several approaches to BI, namely, in a more technical perspective, this paper addresses the topic in a managerial and decisional point of view, and studies it regarding his impact in startups competitiveness, thru the mediating effect of EO.
Blinds up or down?
Authors: Foscht Thomas , Lin Yuting , Eisingerich Andreas B. 
Published: February 2018

Purpose
This paper aims to explore how and when a business’ transparency leads to greater willingness to engage in sustainable and responsible consumption by consumers.

Design/methodology/approach
Data were collected in two studies. Study 1 collected data from 219 consumers in a large shopping mall. Study 2 followed an experimental approach and used data from 327 participants.

Findings
The current research contributes to theory by hypothesizing and demonstrating when transparency is associated with higher willingness for sustainable and responsible consumption. Critically, the positive benefits of transparency vary according to a business’ future orientation, corporate social responsibility (CSR) and levels of customer involvement.

Practical implications
An important societal and practical implication of the current research is that business should not be expected to only focus on transparency in isolation but rather also needs to consider levels of perceived future orientation, CSR and levels of customer involvement to strengthen sustainable and responsible behavior effectively.

Originality/value
This research builds on and extends current knowledge by exploring the key role of business’ transparency in influencing sustainable and responsible customer behavior and examines critical boundary conditions for the observed effects.
Talent development: a systematic literature review of empirical studies
Authors: Rezaei Fatemeh , Beyerlein Michael 
Published: February 2018

Purpose
The purpose of this study is to identify and examine findings from empirical research regarding organizations’ talent development (TD) strategies, taking into consideration the countries in which the studies were conducted and the TD-approach organizations adopted, and recognize the positive outcomes of TD implementation, as well as potential issues and challenges.

Design/methodology/approach
This systematic literature review used Garrard’s matrix method to organize the review of publications. It identified 31 empirical articles from the total of 551 publications.

Findings
The findings indicate that a majority of the studies were conducted in countries other than the USA and that they were all published recently, after 2007. The results show that organizations have mostly applied organizational development interventions at the individual level for developing talented employees, followed by formal training and development. Additionally, managerial issues were identified as the most common issue on the way of implementing TD interventions.

Research limitations/implications
Trying to define TD as a discrete concept from HRD could be considered as both differentiating the current literature review and a limitation.

Originality/value
This article is among the first to identify TD interventions through a systematic literature review and provides a model of TD’s intervention antecedents and outcomes for the follow-up empirical works.
Key predictors of individual creativity in a Middle Eastern culture
Authors: Zaitouni Michel , Ouakouak Mohammed Laid 
Published: February 2018

PurposeThe purpose of this paper is to develop and empirically test a model in which antecedents of creativity are hypothesized to lead to enhance employee creativity and, subsequently, to increase innovative performance outcomes. Leader–member exchange (LMX) is posited as a moderator of the leader encouragement of creativity and employee creativity relationship.Design/methodology/approachThis study is based on a sample of 163 employees working in various service organizations in Kuwait and pursuing an MBA. Structural equation modeling techniques with AMOS software were used to assess the relationships between the different constructs.FindingsThe findings show that all creativity antecedents are positively and significantly related to individual creativity, except for leader encouragement of creativity and perceived organizational support. The results show also that LMX mediates the relationship between leader encouragement of creativity and individual creativity, and that intrinsic motivation moderates the relationship between perceived organizational support and individual creativity.Research limitations/implicationsThis study has several limitations including a small sample size, cross-sectional design, same-source bias and one point in time data. Future studies could examine these findings in different settings, use longitudinal design and capture a full range of creativity antecedents,Originality/valueThis study is the first to theorize and identify antecedents that promote individual creativity in a collectivist context (i.e. Kuwait). Moreover, this study is unique in that we predict that employee creativity is a mediating mechanism that can explain the link between creativity antecedents and creativity outcomes.
Multilevel institutional analysis of accounting change in public management
Authors: Alsharari Nizar Mohammad 
Published: February 2018

PurposeThis paper aims to provide a multilevel institutional analysis of public sector accounting change. It seeks to explain the implementation of changes to state-sector budgeting systems, taking into account the complex of factors that drive and shape the cumulative processes of accounting change.Design/methodology/approachThe study presents the results of an interpretive case study set in a Jordanian public organization, Jordan Customs. It uses triangulation of data collection methods including interviews, observations and documents and archival records. The study adopts a multilevel analysis of institutions to better understand the implications of public accounting changes for the re-engineering and improved delivery of public services in Jordan.FindingsThe paper concludes from its analysis of public sector organizations that change in their accounting systems has occurred on three institutional levels. New budgeting methodologies were produced and reproduced based on re-consideration and re-enacting of theoretical accounting bases and procedures. Through this process, accounting change was itself reformed and new accounting routines further embedded extant accounting institutions and norms. Budgeting change, as a fundamental accounting change, is in this conception generated by external pressures and institutionalized in accounting routines over time.Research limitations/implicationsThe paper is subject to the limitations of the case study approach. The propositions presented from the case studied need to be confirmed in further research into accounting system changes in other public organizations. The authenticity of the conclusions of this study would be greatly enhanced if supported by findings from other studies. The study has significant implications for the ways in which the dynamics of accounting change emerge at three levels of institutional analysis. By explaining the interaction between the “external” sources of and “internal” responses to change, accounting practice is shown to be both formed by and formative of broader socioeconomic processes. This overall sensitivity to the nature of accounting has significant implications for how accounting change can be studied.Originality/valueThe paper presents an interpretive case study of the practical issues of organizational change in a multilevel analysis that considers the experience of institutional pressures from the perspective of organizational actors. The study contributes to both management accounting literature and institutional theory by providing further understanding of the dynamics of accounting change in a developing nation’s public sector.
The influence of open/closed innovation on employees’ performance
Authors: Alawamleh Mohammad , Bani Ismail Loiy , Aladwan Khaled , Saleh Aya 
Published: February 2018

Purpose
The purpose of this paper is to examine critically the different influences of open/closed innovation on employees’ performance.

Design/methodology/approach
The paper takes into account the different influence of open and closed innovation on the performance of employees. Some previous literature was reviewed and the quantitative method used a structured questionnaire to collect primary data from participants.

Findings
The results indicated that open innovation was more influential on the performance of employees than closed innovation. It also appeared that the case study organization uses the open innovation approach in the investments department to attract more clients and investments and thus increase its benefits.

Practical implications
The paper presents a critical account of differences in the influence on employees’ performance between open and closed innovation; it also takes into account the pros and cons of both aspects and their influence on the overall performance of the organization, putting into perspective the recommendations for the best approach to guarantee a good orientation within the internal environment of the organization. Finally, it helps in understanding the best approach to attract talent and creativity to the organization.

Originality/value
It is expected that the current research will offer guidance to organizations in Jordan to draw up plans for effective management of innovative approaches both internally and externally. It highlights the practice of open innovation and its role in attracting talent to the organization, to boost employees’ performance.
Are strategic orientations and managerial characteristics drivers of performance in the US wine industry?
Authors: Gilinsky Armand , Newton Sandra , Eyler Robert 
Published: February 2018

PurposeThe purpose of this study is to investigate the impact of strategic orientations and managerial characteristics on the performance of wine businesses in the US wine industry. Also considered is the power of firm size as measured by production and firm age since founding, as moderating variables that could attenuate or heighten their impact.Design/methodology/approachData were gathered via an online survey, where 306 representatives of the US wineries responded. Data are analyzed using descriptive statistics, multinomial logistic regression, cross-tabulations and Pearson chi-square (χ2) analysis.FindingsWine businesses that reported increased sales and profits over the previous three years made significant changes to organizational structure and staffing levels. Wineries that reported flat or decreasing sales and profits were less apt to make changes in organizational structure or staffing levels. Firm age was found to mediate performance in terms of incremental sales and profit growth; firm size was found to mediate only incremental profit growth.Practical implicationsDeveloping skills in marketing, strategic planning and entrepreneurial thinking to build a defensible industry position and to create the staffing and structure to support that position appear to be of great importance to wine businesses.Originality/valueThis study develops and tests a model investigating how firm size and age impact strategic orientations and managerial characteristics on the performance of the US wine businesses. This study investigates which strategic orientations and managerial characteristics wine businesses need to be successful in the future.
A context-based study of serendipity in information research among Chinese scholars
Authors: Zhou Xiaosong , Sun Xu , Wang Qingfeng , Sharples Sarah 
Published: February 2018

Purpose
The current understanding of serendipity is based primarily on studies employing westerners as the participants, and it remains uncertain whether or not this understanding would be pervasive under different cultures, such as in China. In addition, there is not a sufficient systematic investigation of context during the occurrence of serendipity in current studies. The purpose of this paper is to examine the above issues by conducting a follow-up empirical study with a group of Chinese scholars.

Design/methodology/approach
The social media application “WeChat” was employed as a research tool. A diary-based study was conducted and 16 participants were required to send to the researchers any cases of serendipity they encountered during a period of two weeks, and this was followed by a post-interview.

Findings
Chinese scholars experienced serendipity in line with the three main processes of: encountering unexpectedness, connection-making and recognising the value. An updated context-based serendipity model was constructed, where the role of context during each episode of experiencing serendipity was identified, including the external context (e.g. time, location and status), the social context and the internal context (e.g. precipitating conditions, sagacity/perceptiveness and emotion).

Originality/value
The updated context model provides a further understanding of the role played by context during the different processes of serendipity. The framework for experiencing serendipity has been expanded, and this may be used to classify the categories of serendipity.
Social cognition in intellectually disabled male criminal offenders: a deficit in affect perception?
Authors: Wilson Rogers Luke Patrick , Robertson John , Marriott Mike , Belmonte Matthew Kenneth 
Published: February 2018

PurposeAlthough intellectual disability (ID) and criminal offending have long been associated, the nature of this link is obfuscated by reliance on historically unrigorous means of assessing ID and fractionating social cognitive skills. The purpose of this paper is to review and report current findings and set an agenda for future research in social perception, social inference and social problem solving in ID violent offenders.Design/methodology/approachThe literature is reviewed on comorbidity of criminal offending and ID, and on social cognitive impairment and ID offending. In an exploratory case-control series comprising six violent offenders with ID and five similarly able controls, emotion recognition and social inference are assessed by the Awareness of Social Inference Test and social problem-solving ability and style by an adapted Social Problem-Solving Inventory.FindingsViolent offenders recognised all emotions except “anxious”. Further, while offenders could interpret and integrate wider contextual cues, absent such cues offenders were less able to use paralinguistic cues (e.g. emotional tone) to infer speakers’ feelings. Offenders in this sample exceeded controls’ social problem-solving scores.Originality/valueThis paper confirms that ID offenders, like neurotypical offenders, display specific deficits in emotion recognition – particularly fear recognition – but suggests that in ID offenders impairments of affect perception are not necessarily accompanied by impaired social problem solving. The implication for therapeutic practice is that ID offenders might be most effectively rehabilitated by targeting simpler, low-level cognitive processes, such as fear perception, rather than adapting treatment strategies from mainstream offenders.
Team diversity and its management in a co-design team
Authors: Trischler Jakob , Kristensson Per , Scott Don 
Published: February 2018

Purpose
The purpose of this paper is to explore the conditions under which a co-design team comprised of in-house professionals and leading-edge service users can generate innovative service design concepts.

Design/methodology/approach
The investigation used a field-experimental design to conduct two studies. Observations and open-ended questionnaires were used to examine cross-comparison matrices with experts rating the generated outcomes and t-tests being used to compare the outcome ratings between teams of different compositions.

Findings
The outcomes produced by a co-design team seem to be linked to the team diversity – process facilitation relationship. Bringing a variety of knowledge and skills into the team can lead to original outcomes, while a high disparity between members’ backgrounds can require extensive efforts to facilitate a collaborative process. Separation between users’ objectives can result in a user-driven process and outcomes that are too specific for the broader marketplace. Co-design teams that characterize minimum separation, maximum variety, and moderate disparity are likely to produce the most promising results.

Research limitations/implications
The research was restricted to a narrowly defined study setting and samples. Future research should replicate the current study in other service contexts using different team compositions.

Practical implications
Co-design requires the careful selection of users based on their background and motivations, as well as the facilitation of a process that enables the team to collaboratively transform relevant knowledge into innovative outcomes.

Originality/value
The research contributes to a better understanding of the team composition – process facilitation relationship affecting innovation outcomes. Doing so provides a more fine-grained picture of the co-design team composition and the facilitation requirements for service design.