bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fabrication of polyimide-based tunable ternary memristors doped with Ni-Co coated carbon composite nanofibers
Authors: Liu Yuanyuan , Zhao He , Liu Liyuan , Yin Jinghua 
Published: September 2024

Polymer matrix composite memristors exhibit exceptional performances, including a straightforward structure, rapid operational speed, high density, good scalability, cost-effectiveness, and superior mechanical flexibility for wearable applications. This study utilizes sensitized chemical evaporation and spin coating carbonization techniques to fabricate composite nanofibers doped with Nickel-Cobalt coated multi-walled carbon nanotubes (SC-NCMTs). A novel polyimide matrix composite memory device was fabricated using in-situ polymerization technology. The transmission electron microscopy (TEM) and micro-Raman spectroscopy analyses validate the presence of dual interfaces structure locating between the Ni-Co-MWNTs, carbon nanofibers and PI matrix and a large number of defects in the SC-NCMTs/PI composite films, resulting in tunable ternary resistive switching behaviors of the composite memory device, exhibiting good ON/OFF current ratio of 104 and a retention time of 2500 s under operating voltages Vonset ≤ 3 V. Based on the interface layer distribution and the defects in the composites, different physical models are comprised to investigate the charge transmission mechanism underlying the multilevel resistive switching behaviors. The studies on the impact of tunable multi-interfaces trap structures on multilevel resistive switching could enhance the data storage capabilities of polymer matrix memristors.
A comparative study based on ainuovirine/lamivudine/tenofovir against HIV-1
Authors: Luo Peipei , Jin Juan , Li Jiajia , Yin Jinling , Jing Xinyan , Hou Haohua , Ba Huanhuan , Zhang Yuan 
Published: September 2024

Background Ainuovirine, as a third-generation non-nucleoside reverse transcriptase inhibitor against HIV-1, is widely used in China. To evaluate its therapeutic efficacy and disadvantages, a comparative study based on Ainuovirine had been conducted. Method We investigated 199 people living with HIV-1 who received Ainuovirine (ANV)/lamivudine/tenofovir and 202 people living with HIV-1 who received Efavirenz (EFV)/lamivudine/tenofovir. Results After 48 weeks of therapy, ANV and EFV showed similar viral inhibitory effects. However, in the ANV group, more participants had CD4/CD8 ratios restored to the normal range, lower levels of triglycerides and low-density lipoprotein, relatively normal liver alanine aminotransferase, and fewer adverse events. Conclusion Therefore, due to its role in immune reconstitution, dyslipidemia, and safety, ANV may be a recommended option for people living with HIV-1.
Ergot alkaloid consumption alters serotonin receptor-induced vasoactivity in ovine umbilical vasculature
Authors: Klotz James L , Britt Jessica L , Greene Maslyn A , Kent-Dennis Coral , Duckett Susan K 
Published: September 2024

Consumption of ergot alkaloids during the second half of gestation has been shown to decrease umbilical artery vasoactivity resulting in decreased birth weights. Negative vascular effects of ergot alkaloids are mediated predominantly through serotonergic and adrenergic receptors in other tissues. Vasoactivity of serotonin (5-HT) receptors 5-HT2A and 5-HT1B/1D in umbilical artery and vein from ewes receiving endophyte-infected seed (E + 1.77 mg ergovaline/hd/d) or a control total mixed ration (CON; 0 mg ergovaline/hd/d) tall fescue seed at d-110 and d-133 of gestation was evaluated. Gravid reproduction tracts were collected from ewes. Two-mm sections of umbilical artery and vein were exposed to increasing concentrations of a 5-HT1B/1D agonist and 5-HT2A agonist. The 5-HT1B/1D agonist did not stimulate a contractile response in artery or vein or either gestation time point. 5-HT2A agonist caused large responses in artery with greatest occurring at d-110 and decreasing in magnitude as days of gestation increased ( p < 0.05). On d-110 and 133 of gestation, arteries from CON ewes had greater contractile response than arteries collected from E+ ewes ( p < 0.05). Veins responded to increasing concentrations of the 5-HT2A agonist. Maximal d-110 vein response was greater than d-133 when exposed to 5-HT2A agonist ( p < 0.05). Unlike the artery, veins from E+ ewes had greater d-133 contractile response than CON ( p < 0.05). Vascular contractions of umbilical artery and vein are induced by 5-HT2A receptor activity and not 5-HT1B/1D. Umbilical artery 5-HT2A receptor activity was more sensitive to seed treatment and could be responsible for ergot alkaloid-induced intra-uterine growth restriction.
Alterations of the microbiome across body sites in systemic lupus erythematosus: A systematic review and meta-analysis
Authors: Wang Yiyu , Wu Hong , Yan Chengrui , Huang Ronggui , Li Kaidi , Du Yujie , Jin Xue , Zhu Gaoqi , Zeng Hanjun , Li Baozhu 
Published: September 2024

Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unclear etiology. Growing evidence suggests the microbiome plays a role in SLE pathogenesis. However, findings are inconsistent across studies due to factors like small sample sizes and geographical variations. A comprehensive meta-analysis is needed to elucidate microbiome alterations in SLE. Objective This study aimed to provide a systematic overview of microbiota dysbiosis across body sites in SLE through a meta-analysis of alpha diversity indices, beta diversity indices, and abundance taxa of microbiome. Methods A literature search was conducted across four databases to identify relevant studies comparing SLE patients and healthy controls. Extracted data encompassed alpha and beta diversity metrics, as well as bacterial, fungal, and viral abundance across gut, oral, skin, and other microbiota. Study quality was assessed using the Newcastle-Ottawa Scale. Standardized mean differences and pooled effect sizes were calculated through meta-analytical methods. Results The analysis showed reduced alpha diversity and distinct beta diversity in SLE, particularly in the gut microbiota. Taxonomic analysis revealed compositional variations in bacteria from the gut and oral cavity. However, results for fungi, viruses, and bacteria from other sites were inconsistent due to limited studies. Conclusions This meta-analysis offers a comprehensive perspective on microbiome dysbiosis in SLE patients across diverse body sites and taxa. The observed variations underscore the microbiome’s potential role in SLE pathogenesis. Future research should address geographical variations, employ longitudinal designs, and integrate multi-omics approaches.
Factors affecting discrepancies in disease activity evaluation between patients and physicians in systemic lupus erythematosus-The importance of symptoms such as fatigue
Authors: Doi Hiroshi , Ohmura Koichiro , Hashimoto Motomu , Ueno Kentaro , Takase Yudai , Inaba Ryuta , Kozuki Tomohiro , Iwasaki Takeshi , Taniguchi Masashi , Tabuchi Yuya , Shirakashi Mirei , Onizawa Hideo , Tsuji Hideaki , Onishi Akira , Watanabe Ryu , Kitagori Koji , Akizuki Shuji , Murakami Kosaku , Nakashima Ran , Yoshifuji Hajime , Yamamoto Wataru , Itaya Takahiro , Uozumi Ryuji , Tanaka Masao , Morinobu Akio 
Published: September 2024

Objectives There are often discrepancies in the evaluation of disease activity between patients and physicians in systemic lupus erythematosus (SLE). In this study, we examined the factors that affect those evaluations. Methods Physician visual analogue scale (Ph-VAS), patient VAS (Pt-VAS), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2k), glucocorticoid (GC) usage and dose, age, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and three patient-reported outcomes (SLE symptom checklist [SSC], short-form 36 questionnaire [SF-36], and LupusPRO) were obtained from a study performed in 2019 using 225 SLE outpatients of the Kyoto Lupus Cohort at Kyoto University Hospital. Correlations among Ph-VAS, Pt-VAS, or dif (Pt-VAS-Ph-VAS) (Pt-VAS minus Ph-VAS) and other factors were examined. Results We found a significant discrepancy between Pt-VAS (median 38.0 mm) and Ph-VAS (median 18.7 mm) scores ( p < 0.001). SSC score showed a significant correlation with Pt-VAS and dif (Pt-VAS-Ph-VAS) ( p < 0.001). Among SSC items, fatigue showed the most significant correlation with dif (Pt-VAS-Ph-VAS). We also showed that higher dif (Pt-VAS-Ph-VAS) was associated with lower quality of life (QOL) evaluated by SF-36 and LupusPRO. Conclusions Pt-VAS scores tended to be higher than Ph-VAS scores, and the discrepancy was influenced mainly by fatigue. Higher dif (Pt-VAS-Ph-VAS) was associated with lower patient QOL.
Predictors of first hospitalization due to disease activity and infections in systemic lupus erythematosus patients
Authors: Pons-Estel Guillermo J , Quintana Rosana , Ugarte-Gil Manuel F , Harvey Guillermina B , Wojdyla Daniel , Serrano-Morales Rosa , Gómez Puerta José A , García Mercedes A , Catoggio Luis J , Saurit Verónica , Drenkard Cristina , Da Silva Nilzio A , Cavalcanti Fernando , Borba Eduardo , Sato Emilia , Neira Oscar , Massardo Loreto , Vásquez Gloria , Gonzalez Luis Alonso , Guibert-Toledano Marlene , Silveira Luis H , García De La Torre Ignacio , Sauza del Pozo María Josefina , Chacón Rosa , Cardiel Mario H , Orillion Ashley , Sbarigia Urbano , Alemao Evo , Zazzetti Federico , Alarcón Graciela S , Pons-Estel Bernardo A 
Published: September 2024

Objectives To identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort. Methods The first hospitalization after entry into the cohort during these patients’ follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization. Descriptive statistical tests, multivariable logistic, and Cox regression models were performed. Results 1341 individuals were included in this analysis; 1200 (89.5%) were women. Their median and interquartile range (IQR) age at diagnosis were 27 (20–37) years and their median and IQR follow up time were 27.5 (4.7–62.2) months. A total of 456 (34.0%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) for disease activity, infections, or both, respectively. The predictors of the first hospitalization regardless of its cause were: medium (HR 2.03(1.27–3.24); p = 0.0028) and low (HR 2.42(1.55–3.79); p < 0.0001) socioeconomic status, serosal (HR 1.32(1.07–1.62); p = 0.0074) and renal (HR 1.50(1.23–1.82); p < 0.0001) involvement. Antimalarial (AM) use (HR 0.61(0.50–0.74); p < 0.0001) and achieving remission (HR 0.80(0.65–0.97); p = 0.0300) were negative predictors. Conclusions The first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. Conversely, AM use and achieving remission were associated with a lower risk of hospitalizations.
Tribal Health in India: Overcoming Public Health Challenges with a Focus on Tuberculosis
Authors: Kumari Rinki 
Published: September 2024

Introduction: India’s tribal communities face significant public health issues, with tuberculosis (TB) being a major concern. These populations experience a higher TB burden due to limited healthcare access, socioeconomic inequalities, and distinct cultural practices. This study focuses on the prevalence and impact of TB among these communities. Methods: A comprehensive review of literature from databases such as PubMed, Scopus, ResearchGate, and Google Scholar was conducted to analyze the health challenges, particularly TB, affecting India’s tribal populations. Results: The review highlights a significant disparity in TB prevalence between tribal and non-tribal populations. Factors like inadequate healthcare infrastructure, limited medical access, and socioeconomic inequalities, along with cultural practices, complicate TB transmission and treatment, emphasizing the need for culturally tailored interventions. Conclusion: Addressing the TB crisis in India’s tribal communities requires a holistic and culturally sensitive approach. Collaborative efforts among healthcare providers, policymakers, and tribal communities are crucial to improving health outcomes and preserving cultural heritage for a sustainable future.
Total Ankle Arthroplasty as a Correction Tool for Foot Deformities: Analyzing the Impact on Medial Column Alignment Adaptation Through Weightbearing Computed Tomography
Authors: Efrima Ben , Barbero Agustin , Benady Amit , Halimi Yair Green , Lichtenstein Adi , Indino Cristian , Maccario Camilla , Usuelli Federico Giuseppe 
Published: September 2024

Background: While weightbearing computed tomography (WBCT) has been instrumental in analyzing total ankle arthroplasty (TAA) positioning, there is a notable gap in the literature regarding adaptive changes in the foot’s medial column after TAA. This study aims to bridge this gap by comparing preoperative and postoperative alignments of the foot’s medial column and analyzing if a correlation exists between TAA coronal alignment correction and medial column alignment adaptation. Methods: Sixty patients who underwent a lateral approach TAA for end-stage osteoarthritis (OA) between January 2021 and April 2023 were included in this retrospective study. Patients were divided into varus (n = 30) and valgus (n = 30) groups. Preoperative and postoperative WBCT scans were analyzed to measure medial column alignment. Statistical analysis evaluated alignment corrections and correlations. Results: Both groups showed significant plantarflexion of the second tarsometatarsal (TMT) angle, with a median adaptation of −1 degree (IQR −3, 0; P < .01) in the valgus group and −1 degree (IQR −3, 0; P = .03) in the varus group. The varus group exhibited increased plantarflexion of the first TMT angle (median −1 degree, IQR −1, −2; P = .03). Both groups demonstrated increased adduction of the medial column. The talonavicular coverage angle adaptation averaged 7.2 ± 14 degrees ( P < .01) in the valgus and 9 ± 12 degrees ( P < .01) in the varus group. The talo–first metatarsal axial angle adaptation was 5 ± 13 degrees ( P = .03) in the valgus group and 9.5 ± 15 degrees ( P = .08) in the varus group. Conclusion: WBCT analysis revealed significant medial column adaptation post-TAA in varus and valgus alignments. However, no correlation was found between hindfoot correction and forefoot adaptation, making it challenging to predict the need for additional realignment surgeries. Future studies should explore the relationship between tibiotalar correction and medial column alignment to improve outcomes and the influence of total ankle design on medial column adaptation. Level of Evidence: Level III, retrospective case control study.
Delineation of the “Oropharyngeal Mucosa” and Limiting its Dose in Head and Neck Cancer Patients Spares the Oropharynx Without Compromising Target Coverage
Authors: Wang Xueqi , Han Yanyan , Zhi Zheng , Xu Wenzhong , Ge Jianli , Liang Xi , Li Diancheng , He Jianming 
Published: September 2024

Objectives Radiation-induced oropharyngeal injury is a dose-limiting toxicity in head and neck cancer patients. Delineation of the “oropharyngeal mucosa” and limiting its dose to spare the oropharynx was investigated. Methods In this retrospective study, computed tomography imaging from eight patients with previously untreated head and neck cancer was employed. An adaptive contouring brush within the planning software Monaco was used to create an air cavity within the oropharynx, and then the air cavity was expanded uniformly 2 mm to create the “oropharyngeal mucosa”. Three plans were independently generated for each patient: Plan1: dose constraint was applied for the oropharynx; Plan2: dose constraints were applied for the oropharynx and the “oropharyngeal mucosa”; Plan3: dose constraint was applied for the “oropharyngeal mucosa”. T-tests were used to compare the dosimetry variables. Results All plans had adequate target coverage and there were no statistical differences among plans. The mean dose, D30%, D45%, D50%, D85%, D90%, D95%, D100%, V25 Gy, V30 Gy, V35 Gy, V40 Gy, and V45 Gy of the oropharynx and “oropharyngeal mucosa” in Plan1 were significantly higher than those in Plan2 and Plan3. There were no significant differences between Plan2 and Plan3. There were no significant differences in the dosimetric parameters of any other organs at risk. Conclusion Delineation of the “oropharyngeal mucosa” and limiting its dose should be an easy and effective method to spare the oropharynx.
Parents’ Intentions of Human Papillomavirus Vaccination for Students in Vietnam: A Cross-Sectional Study
Authors: Nguyen Lam Thi Phuong , Phan Dung Quoc , Gyan Araba , Nguyen Han Thi Ngoc , Cassell David , Huynh Giao 
Published: September 2024

Background Human papillomavirus (HPV) is known as a common agent of sexually transmitted infections and cervical cancer. One of the most effective ways for parents to protect their children from HPV is by ensuring they receive vaccinations. Aim To determine the percentage of parents who intend to vaccinate their children against HPV and associated factors. Method A cross-sectional study was conducted on 365 parents who had children attending high school in Ha Tinh province, Vietnam, from April to May 2023, using stratified and random sampling methods. Data were collected by a self-administered questionnaire designed based on previous studies and the domains of the Theory of Planned Behavior and Health Belief Model. A multivariable logistic regression was performed to determine the association between several factors and vaccination status. Result A total of 365 participants took part in the study. The rate of parents intending to vaccinate their children against HPV was 55.9%. Knowledge about the HPV disease and vaccine (all P < .05) and the attitude of parents ( P < .001) were determined as the motivation factors that affect the intention to vaccinate children against HPV. Conclusion Many parents still do not have the intention to vaccinate children against HPV. Health education communication should focus on the motivation factors, not only to improve the parents’ knowledge and perspective but also to increase the coverage of the vaccine to prevent cancers caused by HPV.
Postoperative Radiotherapy in Curatively Resected Esophageal Squamous Cell Carcinoma With Occult Recurrent Laryngeal Nerve Lymph Node Metastasis
Authors: Liu Di , Wu Songsong , Ni Jianjiao , Xiang Jiaqing , Zhang Junhua 
Published: September 2024

Objectives Surgery is the mainstream treatment for early-stage esophageal squamous cell carcinoma (ESCC) and occult recurrent laryngeal nerve lymph node metastasis (RLNM) is not uncommon among those with R0 resection. The clinical value of postoperative radiotherapy (PORT) in patients with RLNM only is still controversial. Methods Consecutive patients with early-stage ESCC treated with R0 resection and pathologically confirmed RLNM only from June 2012 to July 2022 were retrospectively reviewed. PORT, covering the supraclavicular and superior mediastinum area (small T-field) at a dose of 50.4 Gy for 28 fractions, was performed in some patients. Propensity score matching (PSM) was performed to balance the baseline characteristics between patients with or without PORT. Pattern of failure, disease-free survival (DFS), and overall survival (OS) were compared. Results Among the 189 patients identified, 69 (35.5%) received PORT and the other 120 (63.5%) did not. After PSM, 154 patients were included in the matched cohort, including 62 in the PORT group and 92 in the non-PORT group. With a median follow-up of 48 (95% CI: 40.3-55.7) months, 69 patients developed their initial disease recurrence in the whole population and PORT significantly decreased the frequency of local recurrence (61.2% vs 21.4%) among those with recurrent disease. Additionally, in the PSM matched cohort, PORT significantly prolonged patients’ DFS (HR 0.393, P = 0.002) and OS (HR 0.462, P = 0.020). Moreover, PORT remained as the independent factor associated with improved DFS (HR 0.360, P = 0.001) and OS (HR 0.451, P = 0.021) after multivariate Cox analyses. In addition, tumor location and pathological TNM stage were found to be independent prognostic factors associated with survival outcomes. Conclusion PORT is associated with improved DFS and OS in ESCC patients with R0 resection and RLNM only, which warrants future validation.
Maternal Cytomegalovirus (CMV) Serology: The Diagnostic Limitations of CMV IgM and IgG Avidity in Detecting Congenital CMV Infection
Authors: Chan Elaine S. , Suchet Ian , Somerset David , de Koning Lawrence , Chadha Rati , Soliman Nancy , Kuret Verena , Yu Weiming , Lauzon Julie , Thomas Mary Ann , Poon Elaine , Zhou Hong Yuan 
Published: September 2024

Introduction: Congenital cytomegalovirus (cCMV) is a common congenital viral infection. Testing for cCMV usually begins with assessing maternal CMV serology, specifically IgM and IgG antibodies. A negative maternal CMV IgM suggests a low risk of recent maternal CMV infection, thereby suggesting a low risk of cCMV in the fetus. Consequently, cCMV is often ruled out when maternal CMV IgM is negative. Methods: In our perinatal autopsy and placental pathology database, we identified 5 cases of cCMV despite negative maternal CMV IgM results in the second trimester. Results: In all 5 cases, fetal abnormalities were first detected by ultrasound in the second trimester, prompting maternal CMV testing. Since second trimester maternal CMV IgM was negative in all cases, cCMV was considered unlikely, thus precluding further prenatal CMV testing in 4 of these cases. The diagnosis of cCMV was subsequently made through placental and/or autopsy examinations. Following this diagnosis, retrospective CMV serology and IgG avidity testing was performed on stored frozen first-trimester maternal blood samples in 3 cases. Among these, the first-trimester samples in 2 cases were IgG+, IgM+, and exhibited low IgG avidity, suggesting a primary maternal CMV infection around the time of conception. In the third case, both first and second-trimester maternal blood samples were IgG+, IgM−, and showed high IgG avidity, suggesting a non-primary maternal CMV infection (i.e., reactivation or reinfection of CMV). Conclusion: A negative maternal CMV IgM in the second trimester cannot exclude cCMV infection. While CMV IgG avidity testing and analysis of stored frozen first-trimester maternal blood samples provide valuable insights, they have limitations. CMV PCR performed on amniotic fluid is a useful prenatal diagnostic tool. For cases of unexplained fetal abnormalities or death, autopsy and placental examination are recommended.