bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobil Monitoring Doppler Ultrasound (MoMDUS) study: protocol for a prospective, observational study investigating the use of artificial intelligence and low-cost Doppler ultrasound for the automated quantification of hypertension, pre-eclampsia and fetal growth restriction in rural Guatemala
Authors: Ramos Edlyn , Piló Palax Irma , Serech Cuxil Emily , Sebaquijay Iquic Elsa , Canú Ajqui Ana , Miller Ann C , Chandrasekeran Suchitra , Hall-Clifford Rachel , Sameni Reza , Katebi Nasim , Clifford Gari D , Rohloff Peter 
Published: September 2024

IntroductionUndetected high-risk conditions in pregnancy are a leading cause of perinatal mortality in low-income and middle-income countries. A key contributor to adverse perinatal outcomes in these settings is limited access to high-quality screening and timely referral to care. Recently, a low-cost one-dimensional Doppler ultrasound (1-D DUS) device was developed that front-line workers in rural Guatemala used to collect quality maternal and fetal data. Further, we demonstrated with retrospective preliminary data that 1-D DUS signal could be processed using artificial intelligence and deep-learning algorithms to accurately estimate fetal gestational age, intrauterine growth and maternal blood pressure. This protocol describes a prospective observational pregnancy cohort study designed to prospectively evaluate these preliminary findings.Methods and analysisThis is a prospective observational cohort study conducted in rural Guatemala. In this study, we will follow pregnant women (N =700) recruited prior to 18 6/7 weeks gestation until their delivery and early postpartum period. During pregnancy, trained nurses will collect data on prenatal risk factors and obstetrical care. Every 4 weeks, the research team will collect maternal weight, blood pressure and 1-D DUS recordings of fetal heart tones. Additionally, we will conduct three serial obstetric ultrasounds to evaluate for fetal growth restriction (FGR), and one postpartum visit to record maternal blood pressure and neonatal weight and length. We will compare the test characteristics (receiver operator curves) of 1-D DUS algorithms developed by deep-learning methods to two-dimensional fetal ultrasound survey and published clinical pre-eclampsia risk prediction algorithms for predicting FGR and pre-eclampsia, respectively.Ethics and disseminationResults of this study will be disseminated at scientific conferences and through peer-reviewed articles. Deidentified data sets will be made available through public repositories. The study has been approved by the institutional ethics committees of Maya Health Alliance and Emory University.
Supplementation practices among pregnant women and those trying to conceive: a population-representative survey in Vancouver, Canada
Authors: Cochrane Kelsey M. , Hutcheon Jennifer A. , Karakochuk Crystal D. 
Published: September 2024

Dietary supplements including vitamins, minerals, and natural health products are commonly consumed by those aiming to optimize fertility and pregnancy outcomes. The aim of this survey was to describe supplementation practices among individuals who were pregnant or trying to conceive in Vancouver, Canada. An online survey was conducted among 500 individuals who were pregnant ( n = 250) or trying to conceive ( n = 250). Participants met a substantial proportion of vitamin and mineral recommendations through supplements alone. Exceptions included calcium, magnesium, and choline, with median (interquartile range (IQR)) supplementation doses reported by those who were pregnant and trying to conceive, respectively, of: 250 (200 and 250 mg) and 250 (200 and 250 mg), 50 (50 and 75 mg) and 50 (50 and 90 mg), and 53 (10 and 150 mg) and 55 (10 and 100 mg), as compared to perinatal recommendations of 1000 mg/day (calcium), 350 mg/day (magnesium), and 450 mg/day (choline). Conversely, median (IQR) doses of folate reported by those who were pregnant and trying to conceive, respectively, were: 1000 (780 and 1000 µg) and 1000 (800 and 1000 µg), with ∼70% overall (337/471) reporting doses ≥1000 µg (the tolerable upper intake level). Most participants (451/500; 90%) reported supplementation with a prenatal multivitamin; of these, 83% reported that supplementation occurred daily. Overall, as diet was not considered, we cannot ascertain whether recommendations for calcium, magnesium, and choline were met through the combination of supplements and foods; however, we believe that additional supplementation with choline may be required to meet recommendations in pregnancy. Excessive folate supplementation has been previously identified as a concern throughout North America; here, we provide further evidence for excessively high doses consumed via supplements.
Measurements of higher-order cumulants of multiplicity and net-electric charge distributions in inelastic proton–proton interactions by NA61/SHINE
Authors:   NA61/SHINE Collaboration, Adhikary H. , Adrich P. , Allison K. K. , Amin N. , Andronov E. V. , Arsene I.-C. , Bajda M. , Balkova Y. , Battaglia D. , Bazgir A. , Bhosale S. , Bielewicz M. , Blondel A. , Bogomilov M. , Bondar Y. , Borucka A. , Brandin A. , Bryliński W. , Brzychczyk J. , Buryakov M. , Camino A. F. , Ćirković M. , Csanád M. , Cybowska J. , Czopowicz T. , Dalmazzone C. , Davis N. , Dmitriev A. , von Doetinchem P. , Dominik W. , Dumarchez J. , Engel R. , Feofilov G. A. , Fields L. , Fodor Z. , Friend M. , Gaździcki M. , Golosov O. , Golovatyuk V. , Golubeva M. , Grebieszkow K. , Guber F. , Igolkin S. N. , Ilieva S. , Ivashkin A. , Izvestnyy A. , Kargin N. , Karpushkin N. , Kashirin E. , Kiełbowicz M. , Kireyeu V. A. , Kolesnikov R. , Kolev D. , Koshio Y. , Kovalenko V. N. , Kowalski S. , Kozłowski B. , Krasnoperov A. , Kucewicz W. , Kuchowicz M. , Kuich M. , Kurepin A. , László A. , Lewicki M. , Lykasov G. , Lyubushkin V. V. , Maćkowiak-Pawłowska M. , Majka Z. , Makhnev A. , Maksiak B. , Malakhov A. I. , Marcinek A. , Marino A. D. , Mathes H.-J. , Matulewicz T. , Matveev V. , Melkumov G. L. , Merzlaya A. , Mik Ł. , Morozov S. , Nagai Y. , Nakadaira T. , Naskręt M. , Nishimori S. , Olivier A. , Ozvenchuk V. , Panova O. , Paolone V. , Petukhov O. , Pidhurskyi I. , Płaneta R. , Podlaski P. , Popov B. A. , Pórfy B. , Prokhorova D. S. , Pszczel D. , Puławski S. , Puzović J. , Renfordt R. , Ren L. , Ortiz V. Z. Reyna , Röhrich D. , Rondio E. , Roth M. , Rozpłochowski Ł. , Rumberger B. T. , Rumyantsev M. , Rustamov A. , Rybczynski M. , Rybicki A. , Rybka D. , Sakashita K. , Schmidt K. , Seryakov A. Yu. , Seyboth P. , Shah U. A. , Shiraishi Y. , Shukla A. , Słodkowski M. , Staszel P. , Stefanek G. , Stepaniak J. , Strikhanov M. , Świderski Ł. , Szewiński J. , Szukiewicz R. , Taranenko A. , Tefelska A. , Tefelski D. , Tereshchenko V. , Tsenov R. , Turko L. , Tveter T. S. , Unger M. , Urbaniak M. , Valiev F. F. , Veberič D. , Vechernin V. V. , Vitiuk O. , Volkov V. , Wickremasinghe A. , Witek K. , Wójcik K. , Wyszyński O. , Zaitsev A. , Zherebtsova E. , Zimmerman E. D. , Zviagina A. , Zwaska R. 
Published: September 2024

AbstractThis paper presents the energy dependence of multiplicity and net-electric charge fluctuations in p+p interactions at beam momenta 20, 31, 40, 80, and 158 $$\text{ Ge }\hspace{-1.00006pt}\text{ V }\!/\!c$$

Ge

V

/

c

. Results are corrected for the experimental biases and quantified with the use of cumulants and factorial cumulants. Cumulant ratios are an essential tool in the search for the critical point of strongly interacting matter in heavy ion collisions. Measurements performed in p+p interactions provide a vital baseline estimation in these studies. The measured signals are compared with the string hadronic models Epos1.99 and FTFP-BERT.
Utilizing 3D seismic velocities within the Triassic Bacton Group to estimate the exhumation of the Rotliegend Group, Blocks 48/8 and 48/9, UK Southern North Sea
Authors: Cafferkey Thomas , Dack Matthew 
Published: September 2024

In the UK Southern North Sea, the exploration of pre-Zechstein structures depends upon accurate depth conversion of reflection seismic data. In Quadrant 48, depth conversion by conventional methods, such as linear velocity v. depth methods (
V
=
kZ
+
V
0
, or ‘
V
0
K
’), is challenging due to the influence of the Sole Pit Inversion. This leads to velocities being higher over the inversion axis than present-day burial would suggest and strong lateral velocity gradients within consistent intervals. To overcome this, velocity modelling was undertaken utilizing advanced seismic velocity extraction techniques to improve spatial resolution over that of well-based point data alone. The seismic velocities have been used to calculate the post-burial uplift of the Bacton Group, using seismic velocities of the unit. The results, which have been calibrated for local halokinesis, approximate Rotliegend Group uplift and aim to further de-risk the depth conversion uncertainty at target level, offering new insight into the inversion of the pre-salt section, with implications for future hydrocarbon exploration.
Development of a Breast Cancer Risk Prediction Model Integrating Monogenic, Polygenic, and Epidemiologic Risk
Authors: Kalia Sarah S. , Boddicker Nicholas J. , Yadav Siddhartha , Huang Hongyan , Na Jie , Hu Chunling , Ambrosone Christine B. , Yao Song , Haiman Christopher A. , Chen Fei , John Esther M. , Kurian Allison W. , Guo Boya , Lindstrӧm Sara , Auer Paul , Lacey James V. , Neuhausen Susan L. , Martinez Maria Elena , Sandler Dale P. , O’Brien Katie M. , Taylor Jack A. , Teras Lauren R. , Hodge James M. , Lori Adriana , Bodelon Clara , Trentham-Dietz Amy , Burnside Elizabeth S. , Vachon Celine M. , Winham Stacey J. , Goldgar David E. , Domchek Susan M. , Nathanson Katherine L. , Weitzel Jeffrey N. , Couch Fergus J. , Kraft Peter 
Published: September 2024

Abstract

Background:
Breast cancer has been associated with monogenic, polygenic, and epidemiologic (clinical, reproductive, and lifestyle) risk factors, but studies evaluating the combined effects of these factors have been limited.

Methods:
We extended previous work in breast cancer risk modeling, incorporating pathogenic variants (PV) in six breast cancer predisposition genes and a 105-SNP polygenic risk score (PRS), to include an epidemiologic risk score (ERS) in a sample of non-Hispanic White women drawn from prospective cohorts and population-based case–control studies, with 23,518 cases and 22,832 controls, from the Cancer Risk Estimates Related to Susceptibility (CARRIERS) Consortium.

Results:
The model predicts 4.4-fold higher risk of breast cancer for postmenopausal women with no predisposition PV and median PRS, but with the highest versus lowest ERS. Overall, women with CHEK2 PVs had &gt;20% lifetime risk of breast cancer. However, 15.6% of women with CHEK2 PVs and a family history of breast cancer, and 45.1% of women with CHEK2 PVs but without a family history of breast cancer, had low (&lt;20%) predicted lifetime risk and thus were below the threshold for MRI screening. CHEK2 PV carriers at the 10th percentile of the joint distribution of ERS and PRS, without a family history of breast cancer, had a predicted lifetime risk similar to the general population.

Conclusions:
These results illustrate that an ERS, alone and combined with the PRS, can contribute to clinically relevant risk stratification.

Impact:
Integrating monogenic, polygenic, and epidemiologic risk factors in breast cancer risk prediction models may inform personalized screening and prevention efforts.
Metabolic Tumor Volume Response after Bridging Therapy Determines Chimeric Antigen Receptor T-Cell Outcomes in Large B-Cell Lymphoma
Authors: Hubbeling Harper , Leithner Doris , Silverman Emily A. , Flynn Jessica , Devlin Sean , Shah Gunjan , Fregonese Beatrice , Wills Beatriz , Bedmutha Akshay , Alarcon Tomas Ana , Parascondola Allison , Saldia Amethyst , Landego Ivan , Hajj Carla , Boardman Alexander P. , Dahi Parastoo B. , Ghosh Arnab , Giralt Sergio , Lin Richard J. , Park Jae , Scordo Michael , Salles Gilles , Yahalom Joachim , Palomba Maria L. , Schöder Heiko , Perales Miguel-Angel , Shouval Roni , Imber Brandon S. 
Published: September 2024

Abstract

Purpose:
Greater disease burden is a well-established predictor of poorer outcomes following chimeric antigen receptor T-cell (CAR T) therapy. Although bridging therapy (BT) is widely used between leukapheresis and CAR T infusion, limited data have evaluated the impact of BT on CAR T outcomes. In this study, we hypothesized that the quantitative dynamics of radiomic cytoreduction during bridging are prognostic.

Experimental Design:
Patients with large B-cell lymphoma treated with CD19-CAR T from 2016 to 2022 were included in the study. Metabolic tumor volume (MTV) was determined for all patients on pre-leukapheresis PET and on post-BT/pre-infusion PET in those who received BT. Patients were stratified into “High” and “Low” disease burden using an MTV cutpoint of 65.4cc established by maximally selected log-rank statistic for progression-free survival (PFS).

Results:
Of 191 patients treated with CAR T, 144 (75%) received BT. In the BT cohort, 56% had a reduction in MTV post-BT. On multivariate analysis, the MTV trajectory across the bridging period remained significantly associated with PFS (P &lt; 0.001); however, notably, patients with improved MTV (High-&gt;Low) had equivalent PFS compared with those with initially and persistently low MTV (Low-&gt;Low; HR for High-&gt;Low MTV: 2.74; 95% confidence interval, 0.82–9.18). There was a reduction in any grade immune effector cell–associated neurotoxicity syndrome in the High-&gt;Low MTV cohort as compared with the High-&gt;High MTV cohort (13% vs. 41%; P = 0.05).

Conclusions:
This is the first study to use radiomics to quantify disease burden pre- and post-BT in a large real-world large B-cell lymphoma cohort. We demonstrate that effective BT can enable initially high–disease burden patients to achieve post–CAR T outcomes comparable with low–disease burden patients.
Second Primary Malignancies after CAR T-Cell Therapy: A Systematic Review and Meta-analysis of 5,517 Lymphoma and Myeloma Patients
Authors: Tix Tobias , Alhomoud Mohammad , Shouval Roni , Cliff Edward R. Scheffer , Perales Miguel-Angel , Cordas dos Santos David M. , Rejeski Kai 
Published: September 2024

Abstract

Purpose:
Chimeric antigen receptor (CAR) T-cell therapy is a potent immunotherapy for hematologic malignancies, but patients can develop long-term adverse events, including second primary malignancies (SPM) that impact morbidity and mortality. To delineate the frequency and subtypes of SPMs following CAR-T in lymphoma and myeloma, we performed a systematic review and meta-analysis.

Experimental Design:
A literature search was conducted in the MEDLINE, Embase, and Cochrane CENTRAL databases. Following the extraction of SPM cases and assignment of malignant origin, we analyzed SPM point estimates using random effects models.

Results:
We identified 326 SPMs across 5,517 patients from 18 clinical trials and 7 real-world studies. With a median follow-up of 21.7 months, the overall SPM point estimate was 6.0% (95% confidence interval, 4.8%–7.4%). SPM estimates were associated with treatment setting (clinical trials &gt; real-world studies), duration of follow-up, and number of prior treatment lines, which were each confirmed as independent study-level risk factors of SPM in a meta-regression model. A subgroup meta-analysis of the four trials that randomized CAR-T versus standard-of-care revealed a similar risk of SPM with either treatment strategy (P = 0.92). In a distribution analysis of SPM subtypes, hematologic malignancies were the most common entity (37%), followed by solid tumors (27%) and non-melanoma skin cancers (16%). T-cell malignancies represented a small minority of events (1.5%). We noted disease- and product-specific variations in SPM distribution.

Conclusions:
These data raise awareness of SPM as a clinically relevant long-term adverse event in patients receiving CAR T-cell therapy. However, our findings do not indicate that SPM frequency is higher with CAR-T versus previous standard-of-care strategies.
Jornalismo e subjetividade: a poética da grande reportagem
Authors: Essenfelder Renato 
Published: September 2024

O artigo é resultado do projeto desenvolvido no âmbito do Grupo de Pesquisa Produção de Conteúdo, ligado ao Mestrado Profissional em Produção Jornalística e Mercado da ESPM-SP, e aplica o método da Análise Pragmática da Narrativa Jornalística para mapear e analisar as estratégias de subjetivação em uso em uma grande reportagem do site Brio, especializado em jornalismo de longo formato. Na reportagem selecionada, que aborda a maior tragédia ambiental da história do país, ocorrida em Mariana (MG) no final de 2015, verificou-se que os recursos típicos da literatura que aparecem com mais frequência e evidência são metáforas e expressões realçadoras da intensidade dramática do relato, como adjetivos e advérbios. No texto, o uso de recursos típicos da literatura parece estar a serviço não apenas de uma preocupação estética, mas também, paradoxalmente, de um esforço de autenticação do discurso jornalístico como portador da verdade ao sublinhar a presença do repórter in loco no local da tragédia, frente a frente com suas vítimas.
Association Between Periconceptional Diet Quality and Hypertensive Disorders of Pregnancy: The Japan Environment and Children's Study
Authors: Okubo Hitomi , Nakayama Shoji F. , Mito Asako , Arata Naoko , Kamijima Michihiro , Yamazaki Shin , Ohya Yukihiro , Kishi Reiko , Yaegashi Nobuo , Hashimoto Koichi , Mori Chisato , Ito Shuichi , Yamagata Zentaro , Inadera Hidekuni , Nakayama Takeo , Sobue Tomotaka , Shima Masayuki , Kageyama Seiji , Suganuma Narufumi , Ohga Shoichi , Katoh Takahiko 
Published: September 2024

Background
Little is known about the relationship of healthy diets, which are widely recommended to prevent diseases in general populations, with the risk of hypertensive disorders of pregnancy (HDP), particular among non‐Western populations with different dietary habits. We aimed to investigate the association between periconceptional diet quality and the risk of HDP among pregnant Japanese women.

Methods and Results
Dietary intake over 1 year before the first trimester of pregnancy was assessed using a validated, self‐administered food frequency questionnaire among 81 113 pregnant Japanese women who participated in a prospective cohort of the Japan Environment and Children's Study. Overall diet quality was assessed by the Balanced Diet Score (BDS) based on adherence to the country‐specific dietary guidelines and the Dietary Approaches to Stop Hypertension (DASH) score. Cases of HDP were identified by medical record transcription. The association between diet quality and HDP risk was examined using Bayesian logistic regression models with monotonic effects. We identified 2383 (2.9%) cases of HDP. A higher BDS was associated with a lower risk of HDP. When comparing the highest with the lowest quintile of the BDS, the adjusted odds ratio (aOR) of HDP was 0.83 (95% credible interval [CrI], 0.73–0.94). The DASH score and HDP risk were inversely associated in a monotonic dose–response manner (aOR per 1‐quintile increase in the DASH score, 0.92 [95% CrI, 0.89–0.95]).

Conclusions
A high‐quality diet, which is recommended for disease prevention in general populations, before conception may also reduce the risk of HDP among pregnant Japanese women.
Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis
Authors: Cavaillès Clémence , Andrews Shea J. , Leng Yue , Chatterjee Aadrita , Daghlas Iyas , Yaffe Kristine 
Published: September 2024

Background
Sleep apnea (SA) has been linked to an increased risk of dementia in numerous observational studies; whether this is driven by neurodegenerative, vascular, or other mechanisms is not clear. We sought to examine the bidirectional causal relationships between SA, Alzheimer disease (AD), coronary artery disease (CAD), and ischemic stroke using Mendelian randomization.

Methods and Results

Using summary statistics from 4 recent, large genome‐wide association studies of SA (n=523 366), AD (n=94 437), CAD (n=1 165 690), and stroke (n=1 308 460), we conducted bidirectional 2‐sample Mendelian randomization analyses. Our primary analytic method was fixed‐effects inverse variance–weighted (IVW) Mendelian randomization; diagnostics tests and sensitivity analyses were conducted to verify the robustness of the results. We identified a significant causal effect of SA on the risk of CAD (odds ratio [OR
IVW
]=1.35 per log‐odds increase in SA liability [95% CI=1.25–1.47]) and stroke (OR
IVW
=1.13 [95% CI=1.01–1.25]). These associations were somewhat attenuated after excluding single‐nucleotide polymorphisms associated with body mass index (OR
IVW
=1.26 [95% CI=1.15–1.39] for CAD risk; OR
IVW
=1.08 [95% CI=0.96–1.22] for stroke risk). SA was not causally associated with a higher risk of AD (OR
IVW
=1.14 [95% CI=0.91–1.43]). We did not find causal effects of AD, CAD, or stroke on risk of SA.

Conclusions
These results suggest that SA increased the risk of CAD, and the identified causal association with stroke risk may be confounded by body mass index. Moreover, no causal effect of SA on AD risk was found. Future studies are warranted to investigate cardiovascular pathways between sleep disorders, including SA, and dementia.
Twenty‐Four‐Hour Post‐Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study
Authors: You Shoujiang , Wang Yanan , Wang Xia , Maeda Toshiki , Ouyang Menglu , Han Qiao , Li Qiang , Song Lili , Zhao Yang , Chen Chen , Delcourt Candice , Ren Xinwen , Carcel Cheryl , Zhou Zien , Cao Yongjun , Liu Chun‐Feng , Zheng Danni , Arima Hisatomi , Robinson Thompson G. , Chen Xiaoying , Lindley Richard I. , Chalmers John , Anderson Craig S. 
Published: September 2024

Background
This study was conducted to determine optimal predictive ability of National Institutes of Health Stroke Scale (NIHSS) measurements at baseline, 24 hours, and change from baseline to 24 hours after thrombolysis on functional recovery in patients with acute ischemic stroke who participated in the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study).

Methods and Results

ENCHANTED was an international, multicenter, 2×2 quasifactorial, prospective, randomized open trial of low‐dose versus standard‐dose intravenous alteplase and intensive versus guideline‐recommended blood pressure lowering in thrombolysis‐eligible patients with acute ischemic stroke. Absolute (baseline minus 24 hours) and percentage (absolute change/baseline × 100) changes in NIHSS scores were calculated. Receiver operating characteristic curve analyses assessed performance of different NIHSS measurements on 90‐day favorable functional recovery (modified Rankin Scale [mRS] score 0–2) and excellent functional recovery (mRS score 0–1). Youden index was used to identify optimal predictor cutoff points. A total of 4410 patients in the ENCHANTED trial were enrolled. The 24‐hour NIHSS score had the highest discriminative ability for predicting favorable 90‐day functional recovery (mRS score 0–2; area under the curve 0.866 versus 0.755, 0.689, 0.764;
P
<0.001) than baseline, absolute, and percentage change of NIHSS score, respectively. The optimal cutoff point of 24‐hour NIHSS score for predicting favorable functional recovery was ≤4 (sensitivity 66.5%, specificity 87.1%, adjusted odds ratio, 9.44 [95% CI, 7.77–11.48]). The 24‐hour NIHSS score (≤3) was the best predictor of 90‐day excellent functional recovery (mRS score 0–1). Findings were consistent across subgroups, including sex, race, baseline NIHSS score, stroke subtype, and age.

Conclusions
In thrombolysis‐eligible patients with acute ischemic stroke, 24‐hour NIHSS score (optimal cutpoint of 4) is the strongest predictor of 90‐day functional recovery over baseline and early change of NIHSS score.

Registration

URL:
https://clinicaltrials.gov
. Unique Identifier: NCT01422616.