bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thirty Years of Multilevel Processes for Adaptation of Livestock Production to Droughts in Uruguay
Authors: Cruz G. , Baethgen W. , Bartaburu D. , Bidegain M. , Giménez A. , Methol M. , Morales H. , Picasso V. , Podestá G. , Taddei R. , Terra R. , Tiscornia G. , Vinocur M. 
Published: October 2017

AbstractMost countries lack effective policies to manage climate risks, despite growing concerns with climate change. The authors analyzed the policy evolution from a disaster management to a risk management approach, using as a case study four agricultural droughts that impacted Uruguay’s livestock sector in the last three decades. A transdisciplinary team of researchers, extension workers, and policy makers agreed on a common conceptual framework for the interpretation of past droughts and policies. The evidence presented shows that the set of actions implemented at different levels when facing droughts were mainly reactive in the past but later evolved to a more integral risk management approach. A greater interinstitutional integration and a decreasing gap between science and policy were identified during the period of study. Social and political learning enabled a vision of proactive management and promoted effective adaptive measures. While the government of Uruguay explicitly incorporated the issue of adaptation to climate change into its agenda, research institutions also fostered the creation of interdisciplinary study groups on this topic, resulting in new stages of learning. The recent changes in public policies, institutional governance, and academic research have contributed to enhance the adaptive capacity of the agricultural sector to climate variability, and in particular to drought. This study confirms the relevance of and need to work within a transdisciplinary framework to effectively address the different social learning dimensions, particularly those concerning the adaptation to global change.
Comparison of ultrasonographic findings in cats with and without azotaemia
Authors: Lamb Christopher R , Dirrig Helen , Cortellini Stefano 
Published: October 2017

Objectives The objective of this study was to identify the renal ultrasonographic (US) findings most strongly associated with azotaemia in cats. Methods US findings in 238 cats with (serum creatinine >180 μmol/l) and 270 cats without azotaemia were compared in a retrospective case-control study. Cats with pre-renal azotaemia or urethral obstruction were excluded. Data extracted from the medical records included age, body weight and body condition score (BCS). Quantitative and subjective US findings were extracted from archived ultrasound images and contemporaneous reports. Results In non-azotaemic cats, mean ± SD renal length was 40.1 ± 5.5 mm. Male cats had larger kidneys than female cats (mean difference 5.2 mm; P = 0.001) and, on average, the right kidney was slightly larger than the left (mean difference 1.6 mm; P = 0.01). Azotaemic cats had significantly lower mean body weight and BCS, and greater mean age and renal pelvic diameter. Renal pelvic diameter was negatively correlated with urine specific gravity (ρ –0.44, P <0.001). Compared with non-azotaemic cats, there was no difference in mean renal length of azotaemic cats because the numbers with enlarged kidneys and small kidneys were similar. Radiologists’ subjective assessments of renal size differed markedly between azotaemic and non-azotaemic cats, with azotaemic cats more likely to be recorded falsely as having abnormally small or enlarged kidneys. US findings significantly associated with azotaemia were perinephric fluid (odds ratio [OR] 26.4, 95% confidence interval [CI] 3.4–207.7), small kidneys (OR 8.4, 95% CI 4.0–17.4), hyperechoic renal cortex (OR 4.1, 95% CI 2.2–7.6), loss of corticomedullary differentiation (OR 4.1, 95% CI 1.8–9.6), renal calculi (OR 2.7, 95% CI 1.4–4.9), enlarged kidneys (OR 2.5, 95% CI 1.2–5.5) and dilated renal pelvis (OR 1.6, 95% CI 1.3–1.9). Conclusions and relevance Perinephric fluid was the US finding most strongly associated with azotaemia in this study and may merit more emphasis than it has received to date. Bias in radiologists’ subjective assessments of renal size suggests that other subjective findings will also be biased.
Fluorophlogopite-bearing and carbonate metamorphosed xenoliths from theCampanian Ignimbrite (Fiano, southern Italy): crystal chemical, geochemical and volcanological insights
Authors: Lacalamita M. , Balassone G. , Schingaro E. , Mesto E. , Mormone A. , Piochi M. , Ventruti G. , Joachimski M. 
Published: October 2017

AbstractFluorine-, boron- and magnesium-rich metamorphosed xenoliths occur in the Campanian Ignimbrite deposits at Fiano (southern Italy), at ∼50 km northeast of the sourced volcanic area. These rocks originated from Mesozoic limestones of the Campanian Apennines, embedded in a fluid flow. The Fiano xenoliths studied consist of ten fluorophlogopite-bearing calc-silicate rocks and five carbonate xenoliths, characterized by combining mineralogical analyses with whole-rock and stable isotope data. The micaceous xenoliths are composed of abundant idiomorphic fluorophlogopite, widespread fluorite, F-rich chondrodite, fluoborite, diopside, Fe(Mg)-oxides, calcite, humite, K-bearing fluoro-richterite and grossular. Of the five mica-free xenoliths, two are calcite marbles, containing subordinate fluorite and hematite, and three are weakly metamorphosed carbonates, composed only of calcite. The crystal structure and composition of fluorophlogopite approach that of the end-member. The Fiano xenoliths are enriched in trace elements with respect to the primary limestones. Comparisons between the rare-earth element (REE) patterns of the Fiano xenoliths and those of both Campanian Ignimbrite and Somma-Vesuvius marble and carbonate xenoliths showthat the Fiano pattern overlaps that of Somma-Vesuvius marble and carbonate xenoliths, and reproduces the trend of Campanian Ignimbrite rocks. Values of δ13C and δ18O depict the same trend of depletion in the heavy isotopes observed in the Somma-Vesuvius nodules, and is related to thermometamorphism. Trace-element distribution, paragenesis, stable isotope geochemistry and data modelling point to infiltration of steam enriched in F, B,Mg and As into carbonate rocks at a temperature of ∼300–450°C during the emplacement of the Campanian Ignimbrite.
Immune reconstitution and survival of 100 SCID patients post–hematopoietic cell transplant: a PIDTC natural history study
Authors: Heimall Jennifer , Logan Brent R. , Cowan Morton J. , Notarangelo Luigi D. , Griffith Linda M. , Puck Jennifer M. , Kohn Donald B. , Pulsipher Michael A. , Parikh Suhag , Martinez Caridad , Kapoor Neena , O’Reilly Richard , Boyer Michael , Pai Sung-Yun , Goldman Frederick , Burroughs Lauri , Chandra Sharat , Kletzel Morris , Thakar Monica , Connelly James , Cuvelier Geoff , Davila Saldana Blachy J. , Shereck Evan , Knutsen Alan , Sullivan Kathleen E. , DeSantes Kenneth , Gillio Alfred , Haddad Elie , Petrovic Aleksandra , Quigg Troy , Smith Angela R. , Stenger Elizabeth , Yin Ziyan , Shearer William T. , Fleisher Thomas , Buckley Rebecca H. , Dvorak Christopher C. 
Published: October 2017

Key Points
Active infection pretransplant adversely impacts survival (81% in patients with active infection vs 95% in infection-free patients; P = .009). Preparative chemotherapy improved 1-year post-HCT median CD4 counts (P = .02) and freedom from IV immunoglobulin (P < .001).
Gemtuzumab ozogamicin for acute myeloid leukemia
Authors: Appelbaum Frederick R. , Bernstein Irwin D. 
Published: October 2017

Abstract
On 1 September 2017, the US Food and Drug Administration (FDA) approved gemtuzumab ozogamicin (GO) for the treatment of adults with newly diagnosed CD33+ acute myeloid leukemia and for patients aged ≥2 years with CD33+ acute myeloid leukemia who have experienced a relapse or who have not responded to initial treatment. This signals a new chapter in the long and unusual story of GO, which was the first antibody–drug conjugate approved for human use by the FDA.
Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish
Authors: Shao Xin , Lakhina Vanisha , Dang Puneet , Cheng Ryan P. , Marcaccio Christina L. , Raper Jonathan A. 
Published: October 2017

Abstract

Background
The axons of Olfactory Sensory Neurons (OSNs) project to reproducible target locations within the Olfactory Bulb (OB), converting odorant experience into a spatial map of neural activity. We characterized the initial targeting of OSN axons in the zebrafish, a model system suitable for studying axonal targeting early in development. In this system the initial targets of OSN axons are a small number of distinct, individually identifiable neuropilar regions called protoglomeruli. Previously, Olfactory Marker Protein-expressing and TRPC2-expressing classes of OSNs were shown to project to specific, non-overlapping sets of protoglomeruli, indicating that particular subsets of OSNs project to specific protoglomerular targets. We set out to map the relationship between the classical Odorant Receptor (OR) an OSN chooses to express and the protoglomerulus its axon targets.

Methods
A panel of BACs were recombineered so that the axons of OSNs choosing to express modified ORs were fluorescently labeled. Axon projections were followed into the olfactory bulb to determine the protoglomeruli in which they terminated.

Results
RNA-seq demonstrates that OSNs express a surprisingly wide variety of ORs and Trace Amine Associated Receptors (TAARs) very early when sensory axons are arriving in the bulb. Only a single OR is expressed in any given OSN even at these early developmental times. We used a BAC expression technique to map the trajectories of OSNs expressing specific odorant receptors. ORs can be divided into three clades based upon their sequence similarities. OSNs expressing ORs from two of these clades project to the CZ protoglomerulus, while OSNs expressing ORs from the third clade project to the DZ protoglomerulus. In contrast, OSNs expressing a particular TAAR project to multiple protoglomeruli. Neither OR choice nor axonal targeting are related to the position an OSN occupies within the olfactory pit.

Conclusions
Our results demonstrate that it is not the choice of a particular OR, but of one from a category of ORs, that is related to initial OSN target location within the olfactory bulb. These choices are not related to OSN position within the olfactory epithelium.
Data retrieval from building information models based on visual programming
Authors: Preidel Cornelius , Daum Simon , Borrmann André 
Published: October 2017

Abstract
Background
With the rising adoption of Building Information Modeling (BIM) in the AEC sector, computational models supersede traditional ways of information provision based on textual documents and two-dimensional drawings. The use of models enables the streamlining of workflows, and the included virtual construction increases the quality of the final product, the building. To create a comprehensive description of a planned building, information from different sources must be combined, specified and regularly updated by the project’s stakeholders. The emerging models are highly structured, and instance files entail large amounts of data. However, in an unprocessed state, these models are of limited suitability for performing engineering tasks as the amount and structure does not match the domain-specific and purpose-oriented views.

Methods
Selection and filtering data for the user’s needs is a well-understood task in computer science, and various approaches are available. A promising approach is the usage of formal query languages. In this paper, selected common query languages are examined and assessed for processing building model information. Based on the analysis, we come to the conclusion that textual query languages are too complex to be employed by typical end users in the construction industry such as architects and engineers.

Results
To overcome this issue, two Visual Programming Languages representing a new, more intuitive mechanism for data retrieval are introduced. The first one, QL4BIM, is designed for general filtering of IFC models, the second one, VCCL, has been developed for Code Compliance Checking. Both languages provide operators based on the Relational Algebra to allow handling of relations - a highly required feature of BIM QLs.

Conclusions
The paper concludes with a discussion of the strengths and limitations of visual programming languages in the BIM context.
Acute lymphoblastic leukemia relapse after CD19-targeted chimeric antigen receptor T cell therapy
Authors: Wang Jiasheng , Hu Yongxian , Huang He 
Published: October 2017

Abstract
CART19 therapy has revolutionized the treatment of CD19+ acute lymphoblastic leukemia, demonstrating an unprecedented complete remission rate; however, as follow-up prolongs, a high relapse rate after CART19 therapy has emerged as one of the major problems. Relapse can be attributed to the loss of leukemic cell immunogenicity, diminished function and amount of CART19 cells, and the inhibitory bone marrow microenvironment. Although studies to prevent and treat relapse have begun, some encouraging results have demonstrated the possibility of decreasing the relapse rate. In this review, we focus on the possible mechanisms behind relapse. We will summarize and propose strategies to prevent and manage relapse on the basis of these potential mechanisms.
Institutional Scientific Review of Cancer Clinical Research Protocols: A Unique Requirement That Affects Activation Timelines
Authors: Ning Ning , Yan Jingsheng , Dietrich Martin F. , Xie Xian-Jin , Gerber David E. 
Published: October 2017

Purpose: The National Cancer Institute (NCI) requirement that clinical trials at NCI-designated cancer centers undergo institutional scientific review in addition to institutional review board evaluation is unique among medical specialties. We sought to evaluate the effect of this process on protocol activation timelines. Methods: We analyzed oncology clinical trials that underwent full board review by the Harold C. Simmons Comprehensive Cancer Center Protocol Review and Monitoring Committee (PRMC) from January 1, 2009, through June 30, 2013. We analyzed associations between trial characteristics, PRMC decisions, protocol modifications, and process timelines using the χ2 test, Fisher’s exact test, Wilcoxon rank sum test, Kruskal-Wallis test, and logistic regression. Results: A total of 226 trials were analyzed. Of these, 77% were industry sponsored and 23% were investigator initiated. The median time from submission to PRMC approval was 55 days. The length of review was associated with trial phase, timing of approval, and number of committee changes/clarifications requested. The median process time was 35 days for those approved at first decision, 68 days for second decision, and 116 days for third decision ( P < .001). The median process time was 39 days if no changes/clarifications were requested, 64 days for one to three changes/clarifications, and 73 days for four or more changes/clarifications ( P < .001). Requested changes/clarifications had a greater effect on industry-sponsored trials than on investigator-initiated trials. Conclusion: NCI-mandated institutional scientific review of oncology clinical trials contributes substantially to protocol activation timelines. Further evaluation of this process and the value added to research quality is warranted.
Design of Dication-Type Amino Acid Ionic Liquids and Their Application to Self-Assembly Media of Amphiphiles
Authors: Fujiwara Saki , Ohno Hiroyuki , Yoshio Masafumi , Kato Takashi , Ichikawa Takahiro 
Published: October 2017

Abstract
Dication-type amino acid ionic liquids have been prepared and their physicochemical properties, such as viscosity, glass transition temperature, Kamlet-Taft parameter, ionic conductivity, and refractive index, have been examined. Comparing these properties of the dication-type amino acid ionic liquids with those of corresponding monocation-type ones, we have investigated the effects of the cation-bridging. In addition, the comparison of aliphatic amino acid ionic liquids and aromatic ones has been also examined. By examining lyotropic liquid-crystalline behavior of an amphiphile in these ionic liquids, we have examined how these modifications of ionic liquids make changes in the potential utility of ionic liquids as self-organization media of amphiphiles. It has been found that critical concentrations of lyotropic liquid-crystalline amphiphiles in ionic liquids are successfully reduced by bridging their cations with covalent bonding and/or introducing aromatic-structures into their anions.
Malachite Green Derivatives for Dye-Sensitized Solar Cells: Optoelectronic Characterizations and Persistence on TiO2
Authors: Harlé Jean-Baptiste , Arata Shuhei , Mine Shinya , Kamegawa Takashi , Nguyen Van Tay , Maeda Takeshi , Nakazumi Hiroyuki , Fujiwara Hideki 
Published: October 2017

Abstract
Derivatives of malachite green, a well-known triphenylmethine dye, have been adapted for third-generation photovoltaic applications as dye-sensitized solar cells (DSSC). The solar cells were developed based on a concentrated Br3−/Br− liquid electrolyte coupled to different trifluoroacetate (TFA−), triflate (TfO−), bromide (Br−) and tetrafluoroborate (BF4−) malachite green salts as dye sensitizers and mesoporous TiO2 anatase as electron collector, and their optoelectronic properties were characterized. The adsorption patterns of such salts at the TiO2 nanoparticle surface were studied by zeta (ζ) potential measurements on colloidal suspensions under neat conditions, and compared to the desorption rates of the dyes when exposed to the DSSC electrolyte. The different affinities of the ionic pairs for the oxide surface and the bulk were found crucial for the stability of the self-assembled monolayer of carboxylic acid-anchored chromophores at the surface, and for the photoconversion efficiency associated therewith. This study aimed at depicting the behavior of the ionic pairs at the surface and gave insights for their physical and chemical stabilization in the DSSC environment.
Insights into pancreatic β cell energy metabolism using rodent β cell models
Authors: Morten Karl J , Potter Michelle , Badder Luned , Sivathondan Pamela , Dragovic Rebecca , Neumann Abigale , Gavin James , Shrestha Roshan , Reilly Svetlana , Phadwal Kanchan , Lodge Tiffany A. , Borzychowski Angela , Cookson Sharon , Mitchell Corey , Morovat Alireza , Simon Anna Katharina , Uusimaa Johanna , Hynes James , Poulton Joanna 
Published: October 2017

Background: Mitochondrial diabetes is primarily caused by β-cell failure, a cell type whose unique properties are important in pathogenesis. Methods: By reducing glucose, we induced energetic stress in two rodent β-cell models to assess effects on cellular function. Results: Culturing rat insulin-secreting INS-1 cells in low glucose conditions caused a rapid reduction in whole cell respiration, associated with elevated mitochondrial reactive oxygen species production, and an altered glucose-stimulated insulin secretion profile. Prolonged exposure to reduced glucose directly impaired mitochondrial function and reduced autophagy. Conclusions: Insulinoma cell lines have a very different bioenergetic profile to many other cell lines and provide a useful model of mechanisms affecting β-cell mitochondrial function.
Sourcing from Suppliers with Financial Constraints and Performance Risk
Authors: Tang Christopher S. , Yang S. Alex , Wu Jing 
Published: October 2017

Two innovative financing schemes have emerged in recent years to enable suppliers to obtain financing for production. The first, purchase order financing (POF), allows financial institutions to offer loans to suppliers by considering the value of purchase orders issued by reputable buyers. Under the second, which we call buyer direct financing (BDF), manufacturers issue both sourcing contracts and loans directly to suppliers. Both schemes are closely related to the supplier’s performance risk (whether the supplier can deliver the order successfully), upon which the repayment of these loans hinges. To understand the relative efficiency of the two emerging schemes, we analyze a game-theoretical model that captures the interactions among three parties (a manufacturer, a financially constrained supplier who can exert unobservable effort to improve delivery reliability, and a bank). We find that, when the manufacturer and the bank have symmetric information, POF and BDF yield the same payoffs for all parties irrespective of the manufacturer’s control advantage under BDF. The manufacturer, however, has more flexibility under BDF in selecting contract terms. In addition, even when the manufacturer has superior information about the supplier’s operational capability, the manufacturer can efficiently signal her private information via the sourcing contract if the supplier’s asset level is not too low. As such, POF remains an attractive financing option. However, if the supplier is severely financially constrained, the manufacturer’s information advantage makes BDF the preferred financing scheme when contracting with an efficient supplier. In particular, the relative benefit of BDF (over POF) is more pronounced when the supply market contains a larger proportion of inefficient suppliers, when differences in efficiency between suppliers are greater, or when the manufacturer’s alternative sourcing option is more expensive. The online appendix is available at https://doi.org/10.1287/msom.2017.0638 . This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Interface of Finance, Operations, and Risk Management.
Trade Credit Financing Under Competition and Its Impact on Firm Performance in Supply Chains
Authors: Lee Hsiao-Hui , Zhou Jianer , Wang Jingqi 
Published: October 2017

Using a dyadic panel data set that links U.S. suppliers with their major buyers, we study how trade credit responds to various types of competition in supply chains, as well as the impact of trade credit on firm performance. We find that suppliers with smaller market share are associated with more trade credit, confirming that suppliers with weak market power use trade credit as a competitive tool. Next, we find that buyers with larger market share are associated with more trade credit, whereas suppliers selling to a concentrated buyer base are associated with less trade credit; by differentiating competition in buyers’ markets from competition between supply chain partners, we show that the two types of competition have different impacts on trade credit. In studying the impact of trade credit on firm performance, we make the distinction between an industry-average trade credit and an individual supply chain’s deviation from such an industry average. When suppliers offer trade credit at their industry-average level, this action facilitates trade and, thus, is positively associated with both parties’ performance; conversely, when suppliers are more aggressive in their trade credit strategy than the industry average, then the excess trade credit is negatively associated with buyer performance. One managerial message from our research is that buyers should be cautious about trade credit far exceeding the industry-average level. The online appendix is available at https://doi.org/10.1287/msom.2017.0640 . This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Interface of Finance, Operations, and Risk Management.