bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Amphiphilic Immunogens by Cu2+-Mediated Complexes of Water-Born Poly(N-Isopropylacrylamide) and Bovine Serum Albumin
Authors: Mustafaev Mamed I. , Mustafaeva Zeynep , Bermek Engin , Osada Yoshihito 
Published: July 2017

Cu2+-mediated complex formation between temperature-responsive poly(N-isopropylacylamide-co-acrylic acid) (CP) and bovine serum albumin (BSA) was investigated in neutral and in physiological salt solutions. Water soluble or insoluble ternary complexes are formed upon addition of divalent copper ions to the solution. Stability of the ternary polycomplexes depends on the composition of the copolymers, concentration of copper ions and ratio of components. Stimuli-sensitive (temperature, pH- and ionic strength-) behavior of CP, CP-Cu2+ and CP-Cu2+-BSA solution was studied. The ternary CP-Cu2+-BSA complexes exhibit reversible temperature-responses in physiological salt solutions at suitable ratios of the components. Thermal collapse of ternary polycomplexes was observed in higher pH solutions than for CP and CP-Cu2+. The negative temperature solubility coefficient in salt containing solutions may be due to cooperative hydrophobic interactions. Cu2+ in 0.154 M NaCl solutions of CP with BSA, in contrast to CP-Cu2+ BSA complexes in water, gave increased BSA-specific immunogenicity. A single immunization of mice with ternary CP1-Cu2+-BSA complexes in physiological salt solutions without adjuvant increased the specific immune response to BSA. The highest level of immunogenic activity was after a second immunization which lasted more than 18 months. The highest immunogenic activity was exhibited by stable ternary complexes, and immunoactive polycomplexes with a negative temperature solubility coefficient. A hypothetical structural model for the formation of ternary polycomplexes and mechanism for the manifestation of immunological activity are presented.
Energy Consumption in Leisure Centres – A Comparative Study
Authors: Griffiths A.J. , Bowen P.J. , Brinkworth B.J. , Morgan I.R. , Howarth A 
Published: July 2017

The Sports and Recreation sector within the UK uses the equivalent of 3 millions tonnes of coal per year to supply the activities demanded by an ever increasing sports conscience society. The government has attempted to stimulate energy efficiency in this sector through the use of good practice guides and case studies. A comparative study was undertaken to analyse the performance of two leisure complexes in the Seven Valley degree day region. One site had double the occupancy rate of the other. It was found that the energy consumption per user was approximately 10 kWh for both sites. However the energy cost per user showed a large difference: for Site A this index was 31p/user compared to 15p/user at Site B. The primary causes of this difference are attributed to variation in energy mix between the two sites, as well as a difference in the price paid for primary fuel. Indices based on floor area of the facilities exhibit similar trends, and furthermore show that both sites were in the high band of energy consumption. This indicated that both sites had the potential to make significant energy-related savings, and a further breakdown of electrical, natural gas and water consumption per site is used to identify these potential savings in a rapidly expanding sector.
Contribution of tumor necrosis factor alpha to endotoxin-induced mucosal dysfunction in the feline jejunum
Authors: Mueller P.O. Eric , Eades Susan C. , Moore James N. , Barton Michelle H. 
Published: July 2017

Tumor necrosis factor α (TNFα) occupies a pivotal role in the development of shock and tissue injury during endotoxemia and septicemia, and may be an important trigger in the pathogenesis of endotoxin-induced intestinal mucosal dysfunction. This study investigated the contribution of TNFα to endotoxin-induced mucosal dysfunction and the efficacy of polyclonal anti-TNFα antibody in preventing endotoxin-induced mucosal dysfunction. To evaluate mucosal dysfunction, jejunal blood-to-lumen clearances of chromium 51-labeled ethylenediaminetetraacetate ([51Cr]-EDTA) were measured in cats administered fetal calf serum (controls), endotoxin, TNFα, or polyclonal anti-TNFα antibody and endotoxin. Serum TNFα activity was determined using a modified in vitro cytotoxicity bioassay using the murine fibrosarcoma cell line, WEHI-164 clone 13. Endotoxin and TNFα induced jejunal mucosal dysfunction as indicated by increases in [51 Cr]-EDTA clearance. Mucosal dysfunction was accompanied by marked increases in serum TNFα activity. Furthermore, pretreatment with polyclonal anti-TNFα antibody prevented endotoxin-induced mucosal dysfunction and markedly reduced the associated increase in serum TNFα activity. The findings of this study suggest that TNFα is an important mediator of endotoxin-induced mucosal epithelial barrier dysfunction.
Determinants of Language Choice in Bilingual Children: The Role of Input
Authors: Kasuya Hiroko 
Published: July 2017

Each bilingual family will have its own particular circumstances which will determine who speaks which language to whom, and when. Some children growing up in such a family from birth will use two languages actively while others will limit themselves to one (Arnberg, 1987; Clyne, 1982; De Houwer, 1995). It is poorly understood how the type of input, and particularly parental discourse strategies, or the amount of input, are related to children's language choice. This study examines what degree of parents' consistency in their language choice promotes their children's active bilingualism and what kinds of discourse strategies Japanese-speaking parents provide when children use English (the societal language). These issues are investigated through longitudinal analyses of four English/Japanese bilingual children's dyadic interactions with their Japanese-speaking parents. The results show that there were huge individual differences between parent-child pairs in terms of amount of talk. However, the Japanese parent's consistency in using Japanese with the child appeared to be related to the child's choice of Japanese. In addition, a discourse strategy whereby parents made their preference for the use of Japanese quite explicit, had the highest success rate in relation to the child's subsequent choice of Japanese.
High prevalence of myeloid neoplasms in adults with non–Langerhans cell histiocytosis
Authors: Papo Matthias , Diamond Eli L. , Cohen-Aubart Fleur , Emile Jean-François , Roos-Weil Damien , Gupta Nishant , Durham Benjamin H. , Ozkaya Neval , Dogan Ahmet , Ulaner Gary A. , Rampal Raajit , Kahn Jean-Emmanuel , Sené Thomas , Charlotte Frédéric , Hervier Baptiste , Besnard Caroline , Bernard Olivier A. , Settegrana Catherine , Droin Nathalie , Hélias-Rodzewicz Zofia , Amoura Zahir , Abdel-Wahab Omar , Haroche Julien 
Published: July 2017

Key Points
Some 10.1% of adults with non–Langerhans cell histiocytosis have a concomitant myeloid neoplasm with each often harboring distinct mutations. The presence of distinct kinase mutations in histiocytosis and myeloid neoplasms resulted in discordant responses to targeted therapy.
Q&A: using Patch-seq to profile single cells
Authors: Cadwell Cathryn R. , Sandberg Rickard , Jiang Xiaolong , Tolias Andreas S. 
Published: July 2017

Abstract
Individual neurons vary widely in terms of their gene expression, morphology, and electrophysiological properties. While many techniques exist to study single-cell variability along one or two of these dimensions, very few techniques can assess all three features for a single cell. We recently developed Patch-seq, which combines whole-cell patch clamp recording with single-cell RNA-sequencing and immunohistochemistry to comprehensively profile the transcriptomic, morphologic, and physiologic features of individual neurons. Patch-seq can be broadly applied to characterize cell types in complex tissues such as the nervous system, and to study the transcriptional signatures underlying the multidimensional phenotypes of single cells.
A climbing motion recognition method using anatomical information for screen climbing games
Authors: Kim Jungsoo , Chung Daniel , Ko Ilju 
Published: July 2017

AbstractScreen climbing games have made a new category of gaming experience between a human climber and a virtual game projected onto an artificial climbing wall. Here, climbing motion recognition is required to interact with the game. In existing climbing games, motion recognition is based on a simple calculation using the depth difference between the climber’s body area and the climbing wall. However, using the body area in this way is devoid of anatomical information; thus the gaming system cannot recognize which part, or parts, of the climber’s body is in contact with the artificial climbing wall. In this paper, we present a climbing motion recognition method using anatomical information obtained by parsing a climber’s body area into its constituent anatomical parts. In ensuring that game events consider anatomical information, a climbing game can provide a more immersive experience for gamers.
A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice
Authors: Li Wei , Bellot-Saez Alba , Phillips Mary L. , Yang Tao , Longo Frank M. , Pozzo-Miller Lucas 
Published: July 2017

ABSTRACT
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficient mice. Furthermore, experimental interventions that increase BDNF levels improve RTT-like phenotypes in Mecp2 mutant mice. Here, we characterized the actions of a small-molecule ligand of the BDNF receptor TrkB in hippocampal function in Mecp2 mutant mice. Systemic treatment of female Mecp2 heterozygous (HET) mice with LM22A-4 for 4 weeks improved hippocampal-dependent object location memory and restored hippocampal long-term potentiation (LTP). Mechanistically, LM22A-4 acts to dampen hyperactive hippocampal network activity, reduce the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs), and reduce the frequency of spontaneous tetrodotoxin-resistant Ca2+ signals in Mecp2 mutant hippocampal neurons, making them comparable to those features observed in wild-type neurons. Together, these observations indicate that LM22A-4 is a promising therapeutic candidate for the treatment of hippocampal dysfunction in RTT.
Caracterización de Señales EEG mediante Wavelet Packet y Entropía Difusa para Tareas de Imaginación Motora
Authors: Medina Boris Alexander , Alvarez López Ramón 
Published: July 2017

Context: Clinical rhythm analysis on advanced signal processing methods is very important in medical areas such as brain disorder diagnostic, epilepsy, sleep analysis, anesthesia analysis, and more recently in brain-computer interfaces (BCI).Method: Wavelet transform package is used on this work to extract brain rhythms of electroencephalographic signals (EEG) related to motor imagination tasks. We used the Competition BCI 2008 database for this characterization. Using statistical functions we obtained features that characterizes brain rhythms, which are discriminated using different classifiers; they were evaluated using a 10-fold cross validation criteria.Results: The classification accuracy achieved 81.11% on average, with a degree of agreement of 61%, indicating a "suitable" concordance, as it has been reported in the literature. An analysis of relevance showed the concentration of characteristics provided in the nodes as a result of Wavelet decomposition, as well as the characteristics that more information content contribute to improve the separability decision region for the classification task.Conclusions: The proposed method can be used as a reference to support future studies focusing on characterizing EEG signals oriented to the imagination of left and right hand movement, considering that our results proved to compared favourably to those reported in the literature.Language: Spanish.
Nurses’ awareness as a result of short term stoma bag life experience<p>Stoma torbası deneyiminin hemşirelerin farkındalıkları üzerine etkisi
Authors: Taylan Seçil , Akıl Yasemin , Cihan Rabia , Arslan Sevban 
Published: July 2017

This is an experimental study conducted for raising awareness about being a patient with stoma in nurses working in surgical services where intestinal stoma is opened in Balcalı Hospital, Çukurova University.The stoma bag was inserted after applying “Introduction and Evaluation Form” which involved 11 questions was developed by the researcher via face-to-face interview technique with the nurses participating in the study and administering “Pre-Application Data Form” consisting after studying with stoma bag, whose 1/3 was filled with water, for 6 hours; “Post-Application Data Form” was administered.In nurses’ evaluation of first three feelings that the patients were experiencing before and after the life experience of using stoma bag for a short time; the difference between the exclusion feeling scores was found to be highly significant (z=-3.411; p=0.001). In the evaluation of the nurses for the question “will you share the information that you have stoma with your friend if you were a person with a stoma” before and after the stoma bag life experiment, the difference was determined to be statistically significant (z=-2.000; p=0.001). The difference between the evaluation scores for the patients to cope with their stomas before and after the application was observed to be highly significant (z=-4.724; p=0.000).Extended English abstract is in the end of PDF (TURKISH) file. ÖzetAraştırma, Çukurova Üniversitesi Balcalı Hastanesi’nde bağırsak stoması açılan cerrahi servislerde çalışan hemşirelerde stomalı hastalarla ilgili farkındalık yaratmak amacıyla yarıdeneysel tipte yapılmıştır.Veriler araştırmacılar tarafından literatür taraması yapılarak hazırlanmış kişisel bilgi formu ve öntest/sontest veri formları ile yüz yüze görüşme tekniği ile toplanmış, sonrasında katılımcı hemşirelere stoma torbası takılmıştır. 1/3’üne kadar su ile doldurulan stoma torbası ile 6 saat çalıştıktan sonra tekrar anket formu uygulanmıştır.Hemşirelerin stoma torbası deneyimi öncesi ve sonrası hastaların en sık yaşadığı ilk üç duyguyu değerlendirmeleri incelendiğinde, dışlanma duygusu puan ortalamalarını diğer ortalamalara göre yüksek olduğu ve aradaki farkın istatistiksel olarak ileri derece anlamlı olduğu saptandı (z=-3.411; p=0.001). Hemşirelerin stoma torbası deneyimi öncesi ve sonrası “stomalı bir birey olsaydınız stomanız olduğunu iş arkadaşlarınız ile paylaşır mıydınız?” sorusunu değerlendirmelerinde farkın istatistiksel olarak anlamlı olduğu belirlendi (z=-2.000; p=0.001).Uygulama öncesi ve sonrası hastaların stomaları ile baş etmelerini değerlendirme puanortalamaları arasındaki farkın ileri derecece anlamlı olduğu görüldü (z=-4.724; p=0.000).
A study on habits of using fitness centre<p>Fitness merkezi kullanım alışkanlıkları üzerine bir araştırma
Authors: Bağcı Emre 
Published: July 2017

This research is conducted in order to investigate habits of using fitness centre, where people enrol in an effort to avoid sedentary lifestyle that has been lately increasing. People tend to start doing regular physical activity in order to get rid of health problems caused by sedentary lifestyle. Fitness centres are one of the most preferred sports grounds because they offer many advantages apart from variety of physical activity opportunities. Therefore, it is important to determine fitness centre using habits for managers to provide better services and also for people to maintain consistency in sports.Within this scope, data from the sports centre located at Balgat district in Ankara province was analysed. The mean age of all the members is 30.62 years. While the mean age of female participants is 30.43 years, it is 30.74 for male participants. Monday is when the centre is used the most with 17.67% while Saturday is the least visited fitness centre day with 9.79%. February with a rate of 10.67% is noted to be the month in which facility is used the most. The least use of the facility occurred in June with a rate of 5.24%. As the hours of intense participation in fitness centre are observed, it is concluded that the highest number of entries to the facility takes place between 18:00 and 19:00. 18.42% of the total number that sums up to 21594 entries takes place during this period. Through this study, it is concluded that people have certain habits regarding using fitness centres.Extended English abstract is in the end of PDF (TURKISH) file.ÖzetBu araştırma fitness merkezlerinin kulanım alışkanlıklarının tespit edilmesi amacıyla yapılmıştır. Hareketsiz yaşamdan kaynaklı sağlık problemlerinden kurtulmak amacıyla insanlar düzenli fiziksel aktiviteye başlama eğiliminde olurlar. Birçok fiziksel aktivite olanağının yanında birçok avantajları sebebi ile fitness merkezleri en çok tercih edilen spor alanlarından birisidir. İnsanların bu merkezleri kullanım alışkanlıklarının belirlenmesi özellikle işletmeciler tarafından daha iyi hizmetin verilebilmesi açısından önem arz etmektedir.Araştırma, Ankara ili Balgat semtindeki fitness merkezi verileri kullanılarak yapılmıştır. Çalışmaya katılanların genel yaş ortalaması 30.62’dir. Kadın katılımcıların yaşları ortalaması 30.43 ve erkek katılımcıların yaş ortalaması 30.74’tür. Pazartesinin, %17.67 ile fitness merkezinin en çok kullanılan günü iken, cumartesinin %9.79 ile fitness merkezinin en az kullanılan günü olduğu görülmüştür. Şubat ayı %8.79 oaranı ile tesisin en yoğun kullanıldığı aydır. Haziran ayı ise %5.24 oaranı ile tesisin en az yoğunlukta kullanıldığı süre olarak kayıt edilmiştir. Fitness merkezinin kullanımının yoğun olduğu saat dilimleri incelendiğinde tesise en çok girişin 18.00 – 19.00 arasında olduğu gözlenmiştir. Toplam girişin %18.42’si ile toplamda 21594 adet giriş bu saat diliminde gerçekleşmiştir. Yapılan bu çalışmada insanların fitness merkezlerini kullanımları ile ilgili bazı alışkanlıkların olduğu görülmüştür
Eye gaze and viewpoint in multimodal interaction management
Authors: Brône Geert , Oben Bert , Jehoul Annelies , Vranjes Jelena , Feyaerts Kurt 
Published: July 2017

AbstractIn this paper, we present an embodiment perspective on viewpoint by exploring the role of eye gaze in face-to-face conversation, in relation to and interaction with other expressive modalities. More specifically, we look into gaze patterns, as well as gaze synchronization with speech, as instruments in the negotiation of participant roles in interaction. In order to obtain fine-grained information on the different modalities under scrutiny, we used the InSight Interaction Corpus (Brône, Geert & Bert Oben. 2015. Insight Interaction: A multimodal and multifocal dialogue corpus.Language Resources and Evaluation49, 195–214.). This multimodal video corpus consists of two- and three-party interactions (in Dutch), with head-mounted scene cameras and eye-trackers tracking all participants’ visual behavior, providing a unique ‘speaker-internal’ perspective on the conversation. The analysis of interactional sequences from the corpus (dyads and triads) reveals specific patterns of gaze distribution related to the temporal organization of viewpoint in dialogue. Different dialogue acts typically display specific gaze events at crucial points in time, as, e.g., in the case of brief gaze aversion associated with turn-holding, and shared gaze between interlocutors at the critical point of turn-taking. In addition, the data show a strong correlation and temporal synchronization between eye gaze and speech in the realization of specific dialogue acts, as shown by means of a series of cross-recurrence analyses for specific turn-holding mechanisms (e.g., verbal fillers co-occurring with brief moments of gaze aversion).
Electrosynthesis and analysis of the electrochemical properties of a composite material: polyterthiophene + titanium oxide
Authors: Hasniou Leila , Nessark Belkacem , Madani Ahmed , Lmimouni Kamal 
Published: July 2017

AbstractA polyterthiophene-titanium oxide (P3T+TiO2) composite material was electrochemically synthesized in dichloromethane-tetrabutylammonium perchlorate CH2Cl2/TBAP containing a monomer (terthiophene) and semiconductor (TiO2) nanoparticles. The obtained material was characterized using electrochemical methods (cyclic voltammetry and electrochemical impedance spectroscopy) and spectrometry analysis [scanning electron microscopy (SEM), spectrophotometer ultraviolet (UV)-visible, energy dispersive X-ray spectroscopy (EDX) and force atomic microscopy (AFM)]. The effect of TiO2 nanoparticles on the photoelectrochemical and optical characteristics of P3T composite films was also studied. The results confirmed the presence of TiO2 nanoparticles in the polyterthiophene matrix. The surface morphology of the (P3T+TiO2) composite films revealed that adding TiO2 nanoparticles increase the film’s roughness values. The addition of TiO2 nanoparticles improve the absorbance of P3T composite films. Moreover, the photocurrent of the composite increased with the TiO2 nanoparticles concentration and showed that this composite material could be used in photoelectrochemical applications such as photovoltaic cells.
Drying Characteristics and Quality of Kiwifruit Slices with/without Osmotic Dehydration under Short- and Medium-Wave Infrared Radiation Drying
Authors: Lyu Jian , Chen Qinqin , Bi Jinfeng , Zeng Mucheng , Wu Xinye 
Published: July 2017

Abstract
In this paper, short- and medium-wave infrared radiation (SMIR) drying characteristics of kiwifruit slices with/without osmotic dehydration (OD) were investigated. High fructose corn syrup (HFCS) was selected as the best osmotic solution and coupled with SMIR. Both infrared drying processes with/without OD occurred mainly in the falling rate period. Results indicated that the Logarithmic model and Page model were best in predicting moisture transfer for the kiwifruit slices with and without OD, respectively. The values of effective diffusivity ranged from 4.10×10‒10 m2/s to 9.52×10‒9 m2/s and from 3.10×10‒10 m2/s to 1.16×10‒8 m2/s for kiwifruit slices with and without OD, respectively. During the overall falling rate period, the activation energy value was 29.51 kJ/mol and 27.44 kJ/mol for the osmosed and non-osmosed kiwifruit slices, respectively. As compared with non-OD, OD pre-treatment could improve the drying characteristics, decrease color change and increase the retention ratios of ascorbic acid and chlorophyll.
Bioanalytical applications of surface-enhanced Raman spectroscopy: de novo molecular identification
Authors: Nguyen Anh H. , Peters Emily A. , Schultz Zachary D. 
Published: July 2017

AbstractSurface-enhanced Raman scattering (SERS) has become a powerful technique for trace analysis of biomolecules. The use of SERS-tags has evolved into clinical diagnostics; the enhancement of the intrinsic signal of biomolecules on SERS active materials shows tremendous promise for the analysis of biomolecules and potential biomedical assays. The detection of the
Editorial
Authors: Venter Francois 
Published: July 2017

This first issue of 2007 covers a refreshing spectrum of legal disciplines ranging from cultural and linguistic issues, to the onus of proof in delict, the censorship debate and research methodology.
Professor Elmene Bray of the University of South Africa analyses the complexities of the recent judgment of the Supreme Court of Appeal in a case involving the sensitive issue of the medium of instruction in public schools in South Africa.