bluuebunny/crossref_metadata_2025_split huggingface dataset:
الحقول الدلالية في لاميّة العرب للشنفرى (ت نحو 70 ق ه): دراسة إحصائية تحليلية
Authors: فريد حمد سليمان  
Published: October 2024

رست رغبتي على ضفاف شاعر حاذق؛ لأغترف من بحره الزاخر الذي تعددت روافده، فوقع اختياري على لاميته التي ذاع صيتها، ودوّت شهرتها، ولا يُخفى أنها تضاهي المعلقات من حيث الشهرة، ولاسيما عندما تردد صداها، وراحت تجد طريقها إلى نفوس المتلقين، فأثارت إعجاب القدماء من اللغويين؛ وذلك لجزالة ألفاظها، ورصف معانيها، ووفرة مادتها اللغوية، وتنوع صورها المستوحاة من الوقع الذي يكابده الشاعر، إذ انعكس على سلوكه، وهذا ما توخيناه في لاميته المشحونة بوصف الغارات والفخر والإباء وقوة التحمل، وقد استعرض في إثنائها أدوات الحرب والصعاب التي واجهته، فضلا عن قساوة الحياة التي خاض غمارها في الصحاري، والمفاوز المترامية الأطراف والواسعة الأرجاء، فلم يجد فيها مأوى سوى أنه يفترش الأرض ويلتحف السماء، متخذا الحيوانات رفاقاً له بعد ما هجر أرحامه وذويه معلناً تمرده على نظام القبيلة، والمجاهرة بعدائه لها، ومن خلال هذه الظروف التي أحدقت به استطاع الانخراط في صفوف الصعاليك والسير على خطاهم.
وسنحاول في هذا البحث دراسة لامية العرب للشنفرى على وفق المستوى الدلالي من المنهج اللغوي، لدراسة أهم الحقول الدلالية المشتركة، وتحليلها؛ لتكوّن حقلاً دلالياً فرعياً، يضم بعض كلمات البيت نفسه؛ وذلك لمعرفة الحقول الدلالية التي كانت موضع اختيار الشنفرى وعنايته، واهتمامه، وتفكيره؛ ولتحديد حجم هذه الحقول في أبيات اللامية، أي عدد الكلمات التي يضمها كل حقل في البيت الواحد، ولمعرفة أنواع العلاقات الدلالية المؤدية إلى إدراج الأبيات مثلما وردت في ديوانه الذي جمعه وحققه الدكتور إميل بديع يعقوب
Public Space and City Functions
Authors: Khan Samna Sadaf , Iftikhar Muhammad Naveed , Khalid Shua 
Published: October 2024

The study explores how public spaces contribute to a city's core functions—economic, social, and political—through a conceptual framework that positions public spaces as central. However, focusing solely on these typologies may not fully address the complexities of contemporary cities. The framework is a starting point to discuss this correlation in a South Asian context.Drawing lessons from various public spaces in cities across the world, the research carries out an in-depth analysis of the public space of Raja Bazaar, a historical market in the centre of Rawalpindi city. Raja Bazaar is a shared street with pedestrian and vehicular movement, fulfilling its role as a trading centre for the city. It has a lot more potential in its unrecognized heritage, food industry, and local crafts which is currently lost in urban challenges. Urban mobility has recently dominated the public space, consequently, suppressing the social function of the street especially for the residents. The political functions and religious festivities still thrive with temporary pedestrianization, pop-up activity and space appropriation at particular times of the year. The study also finds the positive impact of community’s ownership of public spaces. However, even the community engagement and mobilization have limitations in the absence of well-functioning local governments–a major lesson learnt during the implementation of public space revitalization initiatives in Raja Bazar. Recognizing the complex nature of city functions and the diverse characterization of public spaces, the conceptual framework developed under this study needs further investigation through comparative analysis of its application in different neighbourhoods and regions.
DEVELOPMENT OF AN ENERGY-SAVING TECHNOLOGY FOR THE PRODUCTION OF SYNTHETIC METHANE FROM CARBON DIOXIDE. 1. RESEARCH OF KINETICS AND MACRO-KINETICS OF THE SABATIER REACTION ON MODIFICATIONS OF THE SERIAL NI/Α-AL2O3 CATALYST GIAP-3-6N
Authors: Tsiupiashuk A.M. , Кostohryz К.P. , Коlesnik V.V. , Soloviov G.І. 
Published: October 2024

This study presents the results of laboratory research of kinetics and mechanisms of heterogeneous catalytic reactions of hydrogenation of carbon dioxide to carbon monoxide and methane through the Sabatier reaction on modifications of the serial Ni/α-Al2O3 catalyst GIAP-3-6N manufactured in Ukraine. The research was carried out on a laboratory bench using a classic glass gradientless reactor with internal piston stirring, which provides kinetic equations at the level of physicochemical constants of the reactions under consideration. A detailed analysis and review of the literature in the areas of kinetic research of our interest was carried out. A detailed comparison of the kinetic parameters obtained by us for the powder (kinetic) form of contact with a nickel content of 7.5 % (NiO = 7.5 %) with a similar and one of the best foreign analogs containing nickel, Katalco 57-4 (NiO = 15−18 %), produced by the British chemical and metallurgical company Johnson Matthey, was performed. The results of the research confirmed almost equal parameters of the kinetic activity of the compared catalysts in the reactions of hydrogenation of carbon dioxide with hydrogen, including the «Sabatier» reaction, which made it possible to propose a similar mechanism of the processes, calculate the reaction rate constants and their activation energy, propose (determine) kinetic equations for design of reactors and processes, both with the loading of a domestic catalyst and its replacement with a foreign analog. Kinetic equations will be used in the development of multi-ton synthesis gas plants for the production of methanol, ammonia, and synthetic methane, as well as carbon-free e-fuel for internal combustion engines that meet modern climate requirements. Bibl. 28, Fig. 4, Tab. 6.
A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms
Authors: Bardi Francesco , Gasparotti Emanuele , Vignali Emanuele , Antonuccio Maria Nicole , Storto Eleonora , Avril Stéphane , Celi Simona 
Published: October 2024

BackgroundCardiovascular diseases remain a leading cause of morbidity and mortality worldwide and require extensive investigation through in-vitro studies. Mock Circulatory Loops (MCLs) are advanced in-vitro platforms that accurately replicate physiological and pathological hemodynamic conditions, while also allowing for precise and patient-specific data collection. Particle Image Velocimetry (PIV) is the standard flow visualization technique for in-vitro studies, but it is costly and requires strict safety measures. High-power Light Emitting Diode illuminated PIV (LED-PIV) offers a safer and cheaper alternative.MethodsIn this study, we aim to demonstrate the feasibility of a Hybrid-MCL integrated with a LED-PIV system for the investigation of Abdominal Aortic Aneurysm (AAA) compliant phantoms. We considered two distinct AAA models, namely, an idealized model and a patient-specific one under different physiological flow and pressure conditions.ResultsThe efficacy of the proposed setup for the investigation of AAA hemodynamics was confirmed by observing velocity and vorticity fields across multiple flow rate scenarios and regions of interest.ConclusionThe findings of this study underscore the potential impact of Hybrid-MCL integrated with a LED-PIV system on enhancing the affordability, accessibility, and safety of in-vitro CVD investigations.
Mapping the landscape of PSC-CM research through bibliometric analysis
Authors: Li Jun , Han Shangting , Yu Fengxu , Li Tao , Liao Bin , Liu Feng 
Published: October 2024

ObjectivesThe discovery of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) has not only deepened our understanding of the pathogenesis and progression of heart disease, but also advanced the development of engineered cardiac tissues, cardiac regenerative therapy, drug discovery and the cardiotoxicity assessment of drugs. This study aims to visualize the developmental trajectory of PSC-CM research over the past 18 years to identify the emerging research frontiers and challenges.MethodsThe literature on PSC-CMs from 2007 to 2024 was retrieved from the Web of Science and PubMed databases. Bibliometrix, VOSviewer and CiteSpace software were used for statistical analysis and visualization of scientific literature. Previous clinical trials were summarized using data from the ClinicalTrials.gov database.ResultsA total of 29,660 authors from 81 countries and regions published 6,406 papers on PSC-CMs over the past 18 years. The annual output of PSC-CM research experienced a general upward trend from 2007 to 2021, reaching its peak in 2021, followed by a notable decline in 2022 and 2023. The United States has emerged as the most influential nation in this field, with Stanford University being the most prolific institution and Joseph C. Wu standing out as the most productive and highly cited scholar. Circulation Research, Circulation, and Nature have been identified as the most co-cited journals. Organ-on-a-chip, 3D bio-printing, cardiac microtissue, extracellular vesicle, inflammation, energy metabolism, atrial fibrillation, personalized medicine etc., with a longer burst period, and maturation of PSC-CMs, with the highest burst strength of 27.19, are the major research focuses for rigorous investigation in recent years. Cardiac organoid is emerging as a promising key research frontier. While the clinical trials of stem-cell-mediated treatment for heart diseases shows promise, significant challenges remain. Further research is imperative to optimize protocols, enhance cell delivery methods, and establish standardized practices to improve clinical outcomes.ConclusionsIn conclusion, several major research hotspots, including engineered cardiac tissue and maturation, exosome-based regenerative therapy, inflammation response, energy metabolism, atrial fibrillation, and personalized medicine etc. will continue to attract substantial interest from investigators worldwide. Cardiac organoids to in vitro recapitulate the intricate human heart is emerging as a promising key research frontier. Significant challenges persist in the clinical trials of stem-cell-mediated therapies for heart diseases.
Rate of testicular histology failure in predicting successful testicular sperm extraction
Authors: Castellano Stefano , Tondo Francesca , Bulbul Ozgur , Aprea Sabrina , Monti Emanuela , Carnesi Edoardo , Levi Setti Paolo Emanuele , Albani Elena 
Published: October 2024

BackgroundThe management of Non-Obstructive (NOA) Azoospermia or Obstructive Azoospermia (OA) patients relies on testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI). In NOA patients the sperm recovery is successful in only 50% of cases and therefore the ability to predict those patients with a high probability of achieving a successful sperm retrieval would be a great value in counselling the patient and his partner. Several studies tried to suggest predictors of a positive TESE (e.g. FSH concentration), but most concluded that diagnostic testicular biopsy (histology) is best.MethodsThis is a retrospective analysis of 526 TESE patients. After the extraction of the testis, the resulting sample was immediately given to the embryologist, who examined the tubules for sperm cryopreservation. During the same procedure, a different specimen was destined to the histological analysis. The comparison between the two methodological approaches was carried out through a score.ResultsConcordance between TESE and testicular histology outcomes was found in 70,7% of patients; discordance was found in 29,3% of patients. Among the discordance outcomes, in approximately 95% we found at least 1 sperm in the TESE retrieval, while the histology report did not find any spermatozoa or found not enough compared to our evaluation; in only 5% of cases we did not find any spermatozoa or found not enough compared to what was detected in the testicular histology.ConclusionBased on our experience, to increase diagnostic accuracy, a larger biopsy should be sent to the histopathology laboratory; another option may be to use TESE cell suspension (the same embryologists employ for cryopreservation) for cytological evaluation of spermatogenesis.
Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells
Authors: Sennikov Sergey , Volynets Marina , Alrhmoun Saleh , Perik-Zavodskii Roman , Perik-Zavodskaia Olga , Fisher Marina , Lopatnikova Julia , Shevchenko Julia , Nazarov Kirill , Philippova Julia , Alsalloum Alaa , Kurilin Vasily , Silkov Alexander 
Published: October 2024

IntroductionAdoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested against a variety of blood neoplasms but is yet to be deeply tested against solid tumors. Among solid tumors, cancer-testis antigens are the most prominent targets for tumor-specific therapy, as they are usually found on cells that lie behind blood-tissue barriers.MethodsWe have employed a novel efficient protocol for MAGE-A3-specific T-cell clonal expansion, performed single-cell multi-omic analysis of the expanded T-cells via BD Rhapsody, engineered a selected T-cell receptor into a lentiviral construct, and tested it in an in vitro LDH-cytotoxicity test.Results and discussionWe have observed a 191-fold increase in the MAGE-A3-specific T-cell abundance, obtained a dominant T-cell receptor via single-cell multi-omic BD Rhapsody data analysis in the TCRscape bioinformatics tool, and observed potent cytotoxicity of the dominant-clonotype transduced TCR T-cells against a MAGE-A3-positive tumor. We have demonstrated the efficiency of our T-cell enrichment protocol in obtaining potent anti-tumor T-cells and their T-cell receptors, especially when paired with the modern single-cell analysis methods.
On preserving anatomical detail in statistical shape analysis for clustering: focus on left atrial appendage morphology
Authors: Lee Matthew T. , Martorana Vincenzo , Md Rafizul Islam , Sivera Raphael , Cook Andrew C. , Menezes Leon , Burriesci Gaetano , Torii Ryo , Bosi Giorgia M. 
Published: October 2024

IntroductionStatistical shape analysis (SSA) with clustering is often used to objectively define and categorise anatomical shape variations. However, studies until now have often focused on simplified anatomical reconstructions, despite the complexity of studied anatomies. This work aims to provide insights on the anatomical detail preservation required for SSA of highly diverse and complex anatomies, with particular focus on the left atrial appendage (LAA). This anatomical region is clinically relevant as the location of almost all left atrial thrombi forming during atrial fibrillation (AF). Moreover, its highly patient-specific complex architecture makes its clinical classification especially subjective.MethodsPreliminary LAA meshes were automatically detected after robust image selection and wider left atrial segmentation. Following registration, four additional LAA mesh datasets were created as reductions of the preliminary dataset, with surface reconstruction based on reduced sample point densities. Utilising SSA model parameters determined to optimally represent the preliminary dataset, SSA model performance for the four simplified datasets was calculated. A representative simplified dataset was selected, and clustering analysis and performance were evaluated (compared to clinical labels) between the original trabeculated LAA anatomy and the representative simplification.ResultsAs expected, simplified anatomies have better SSA evaluation scores (compactness, specificity and generalisation), corresponding to simpler LAA shape representation. However, oversimplification of shapes may noticeably affect 3D model output due to differences in geometric correspondence. Furthermore, even minor simplification may affect LAA shape clustering, where the adjusted mutual information (AMI) score of the clustered trabeculated dataset was 0.67, in comparison to 0.12 for the simplified dataset.DiscussionThis study suggests that greater anatomical preservation for complex and diverse LAA morphologies, currently neglected, may be more useful for shape categorisation via clustering analyses.
Chronic exposure to inhaled vaporized cannabis high in Δ9-THC suppresses Adderall-induced brain activity
Authors: Ognibene Jack M. , Desai Rajeev I. , Kulkarni Praveen P. , Ferris Craig F. 
Published: October 2024

BackgroundThere are increasing reports of the misuse of prescription psychostimulants for cognitive enhancement together with recreational cannabis. This raises a concern that chronic use of cannabis high in Δ9-THC may alter the sensitivity to amphetamines. In this exploratory study we hypothesized chronic exposure to Δ9-THC through vaporized cannabis would diminish the central nervous system (CNS) activity of Adderall.MethodsTo address this issue we exposed male and female mice to inhaled vaporized cannabis (10.3% Δ9-THC) or placebo for 30 min each day for ten consecutive days. After 24 h, mice were imaged fully awake for changes in BOLD signal following an IP injection of Adderall (60 µg) during the scanning session. After a 2-week washout, without any cannabis or placebo exposure, mice were again imaged and challenged with Adderall during the scanning session. The data were registered to a mouse 3D MRI atlas with 134 brain regions providing site-specific increases and decreases in global brain activity.ResultsMice exposed to cannabis when compared to placebo showed a decrease in brain activation to Adderall. The blunted Adderall response was characterized by a decrease in positive BOLD signal and increase in negative BOLD. The prefrontal cortex, accumbens, ventral pallidum, caudate/putamen, and thalamus were most affected. After a 2-week wash out there were no significant differences between the cannabis and placebo groups when challenged with Adderall.SummaryThis exploratory study shows that short, daily exposures to inhaled cannabis, something equivalent to recreational use, affects the sensitivity to the psychostimulant Adderall. The reduced Adderall effect on brain activity, particularly circuitry associated with dopaminergic signaling raises concerns about escalation in psychostimulant use.
Fei-Yan-Qing-Hua decoction attenuates influenza virus infection by enhancing host antiviral response through microbiota-derived acetate
Authors: Dou Biao , Wu Xiao , He Yurong , Xu Guihua , Zhang Huan , Huang Qilin , Chen Xuan , Duan Naifan , Zhou Linqiong , Zhang Wei , An Huazhang , Zheng Yuejuan 
Published: October 2024

BackgroundFei-Yan-Qing-Hua decoction (FYQHD) is derived from the well-known Ma Xing Shi Gan decoction, which was documented in Zhang Zhong Jing’s “Treatise on Exogenous Febrile Disease” during the Han Dynasty. Although FYQHD has been used in the treatment of pneumonia and has demonstrated clinical efficacy for decades, the underlying mechanism by which FYQHD protects against influenza virus infection through modulation of gut flora remains unclear. Here, we examined the regulatory impacts of FYQHD on an influenza virus-infected mouse model and explored the mechanisms involved.MethodsAn infectious mouse model was created by intranasal instillation of influenza A virus (IAV). The effectiveness of FYQHD was assessed through various measures, including weight loss, lung wet/dry ratio, oxidative stress levels, viral load in lung tissues, and intestinal injuries. Changes in gut microbiota and SCFA production were also examined.ResultsThe results showed that FYQHD significantly reduced viral load, increased the production of type I interferon (IFN-I), and restored the integrity of the intestinal barrier following IAV challenge. Additionally, FYQHD significantly corrected the dysbiosis of gut microbiota induced by influenza virus infection, enhancing the abundance of SCFA-producing bacteria and acetate production. However, the depletion of gut microbiota significantly attenuated the protective effects of FYQHD against influenza virus infection. In vitro, the antiviral effect of acetate was demonstrated through the upregulation of concentrations of IFN-β.ConclusionFYQHD attenuates influenza virus-induced lung and intestinal injuries by boosting the host antiviral response through increasing the abundance of Lachnospiraceae_NK4A136 and Roseburia, along with elevated acetate levels. The study advances our understanding of the therapeutic mechanisms of FYQHD and provides a theoretical basis for the application of FYQHD in the treatment of influenza.
Estimation of mediators in the associations between campus green spaces and students’ anxiety: a case study in Nanjing
Authors: Diao Wanting , Li Silei , Zhao Bing , Zhang Fan 
Published: October 2024

IntroductionAlthough a number of scholars have examined the theoretical pathways between green space (GS) and mental health, few have focused on how campus greenness affects the mental health of Chinese youth.MethodsHerein, two objective indicators, campus and individual 300-m normalized vegetation index (NDVI) data, were used as independent variables. A questionnaire was used to collect the self-rated anxiety level of students on campuses in Nanjing. Then, we chose “subjective perception of campus GS”, “physical activity”, “social cohesion”, “nature relatedness” and “usage pattern” as mediating variables to explore the pathways between the campus greenery and college student’ anxiety level through correlation analysis, linear regression, and mediation effect test.ResultsResults showed the campus-wide NDVI and individual students’ 300-m range NDVI had significant negative correlations with anxiety (p = 0.045, p = 0.023). Campus perception, nature relatedness and the frequency of using GS are the pathways through which campus GSs influence student anxiety.DiscussionOur findings emphasised the importance of subjective perceptions of greenspaces, which provided a direction that can be deepened in future research.
Intranasal dexmedetomidine sedation for EEG in children with autism spectrum disorder
Authors: De Laurentiis Arianna , Pastori Chiara , Pinto Carmela , D’Arrigo Stefano , Estienne Margherita , Bulgheroni Sara , Battaglia Giulia , Gemma Marco 
Published: October 2024

IntroductionThe aim of the study was to assess the efficacy of In-Dex sedation in comparison to oral melatonin and hydroxyzine in individuals with Autism Spectrum Disorder (ASD) undergoing EEG recording and 15 determine which categories of patients exhibit the most favorable response to In-Dex sedation.MethodsThis retrospective observational study involved pediatric patients with ASD who underwent sleep-EEG recording across two periods, before (biennium 2018-19) and after (biennium 2021-22) the routine implementation of In-Dex sedation. Clinical, EEG, and sedation data were stored in a database. A logistic multiple regression model was employed, with the failure of EEG serving as the dependent variable.ResultsIn the first period 203 EEGs were performed with a rate of failure of 10.8%, while in the second one 177 EEGs were recorded with a percentage of failure of 7.3% (8.3% with MH 23 sedation and 5.8% with In-Dex sedation). No significant adverse events were reported in either period. Multivariate logistic analysis demonstrated that In-Dex decreased the probability of failure (OR=0.25, 25 (0.61-0.88)), while the presence of behavioral disturbances (OR=3.65((1.54-8.85)) and the use of antipsychotic drugs (OR=2.76, (1.09-6.95)) increased it.DiscussionIn the light of these results, we can state that In-Dex sedation is safe and reduce EEG failure rate compared to the use of melatonin and hydroxyzine alone, particularly in patients with severe behavioral issues.