bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of virtual reality glasses versus white noise on dental anxiety in children with attention‐deficit hyperactivity disorder: A randomised controlled clinical trial
Authors: Aly Nahla A. , Abdelrahman Amina M. , Omar Tarek E. I. , Dowidar Karin ML 
Published: September 2024

AbstractBackgroundManagement of children with attention‐deficit hyperactivity disorder (ADHD) can be challenging due to their disruptive behaviour. Basic behaviour management techniques (BMTs) may not be sufficient, and adjunctive strategies such as virtual reality (VR) glasses or white noise can be employed.AimTo assess and compare the effectiveness of VR, white noise and basic BMTs on dental anxiety and behaviour of children with ADHD.DesignForty‐eight children with ADHD were recruited for this parallel, three‐armed randomised controlled clinical trial, which involved three visits at one‐week intervals, including examination, preventive measures and restorations. Children were randomly divided into three groups: VR, white noise and basic BMTs. Outcome measures were Faces Image Scale (FIS), Heart Rate (HR) and Venham's Behaviour Rating Scale (VBRS).ResultsNo significant difference was found between the groups in FIS scores. White noise group had a significantly lower mean HR than control group in all visits. Scores of VBRS in VR and white noise groups were significantly lower than those in the control group during the restorative visit.ConclusionsVR and white noise could be beneficial in managing dental anxiety and improving behaviour in children with ADHD and could be used as adjunctive strategies to basic BMTs.
Digital therapeutics in hypertension: How to make sustainable lifestyle changes
Authors: Chen Chaoyi , Liu Aiting , Zhang Zhengzhipeng , Chen Jie , Huang Hui 
Published: September 2024

AbstractVarious digital therapeutic products have been validated and approved since 2017. They have demonstrated efficacy and safety as a new therapeutic modality in various disorders or conditions. Hypertension is a common but serious condition that can be prevented or controlled with lifestyle changes and medicines. Although a digital therapeutic in hypertension is validated and approved in Japan, whether digital therapeutics (DTx) can significantly improve sustainable lifestyle changes is still a controversial topic. Most studies did not discuss the long‐term gain challenges. In this review, the authors discuss the definition of DTx, and analyze the motivation, engagement and adherence challenges of DTx in hypertension. Some ongoing artificial intelligence (AI)‐enabled or cognitive behavioral therapy (CBT)‐based digital interventions and behavioral strategies for implementing sustainable lifestyle changes are identified and analyzed. With AI‐enabled interventions and behavioral strategies, DTx might be one of the effective approaches to make sustainable lifestyle changes.
Multifaceted bioinformatic analysis of m6A‐related ferroptosis and its link with gene signatures and tumour‐infiltrating immune cells in gliomas
Authors: Yang Yang , Hao Liu , Guiyang Liu , Haozhe Piao 
Published: September 2024

AbstractWhether N6‐Methyladenosine (m6A)‐ and ferroptosis‐related genes act on immune responses to regulate glioma progression remains unanswered. Data of glioma and corresponding normal brain tissues were fetched from the TCGA database and GTEx. Differentially expressed genes (DEGs) were identified for GO and KEGG enrichment analyses. The FerrDb database was based to yield ferroptosis‐related DEGs. Hub genes were then screened out using the cytoHubba database and validated in clinical samples. Immune cells infiltrating into the glioma tissues were analysed using the CIBERSORT R script. The association of gene signature underlying the m6A‐related ferroptosis with tumour‐infiltrating immune cells and immune checkpoints in low‐grade gliomas was analysed. Of 6298 DEGs enriched in mRNA modifications, 144 were ferroptosis‐related; NFE2L2 and METTL16 showed the strongest positive correlation. METTL16 knockdown inhibited the migrative and invasive abilities of glioma cells and induced ferroptosis in vitro. NFE2L2 was enriched in the anti‐m6A antibody. Moreover, METTL16 knockdown reduced the mRNA stability and level of NFE2L2 (both p < 0.05). Proportions of CD8+ T lymphocytes, activated mast cells and M2 macrophages differed between low‐grade gliomas and normal tissues. METTL16 expression was negatively correlated with CD8+ T lymphocytes, while that of NFE2L2 was positively correlated with M2 macrophages and immune checkpoints in low‐grade gliomas. Gene signatures involved in the m6A‐related ferroptosis in gliomas were identified via bioinformatic analyses. NFE2L2 interacted with METTL16 to regulate the immune response in low‐grade gliomas, and both molecules may be novel therapeutic targets for gliomas.
Effect of vacuum combined with ultrasound on color protection of pomegranate juice
Authors: Jiang Chunlu , Zhang Min , Wang Yuchuan , Shen Dongbei , Law Chung Lim , Luo Zhenjiang 
Published: September 2024

AbstractPomegranate juice is prone to color fission during processing and storage due to the instability of anthocyanins, resulting in significant economic losses. This study aims to inhibit the browning of pomegranate juice during processing using the combined technology of vacuum and ultrasound for maintaining its color as much as possible. Pomegranate juice was treated with vacuum (0.5 MPa) and ultrasound (300, 600, 900, 1200, and 1500 W; 15, 20, 25, 30, and 35 min), respectively, to investigate the effects on the color, antioxidant capacity, anthocyanin/polyphenol content, and polyphenol oxidase activity of pomegranate juice. The results showed that the combined treatment of vacuum and ultrasound had a better effect on improving the total anthocyanin content of pomegranate juice than vacuum or ultrasound treatment alone. Vacuum combined with ultrasound can reduce the browning during pomegranate juice processing, increasing browning inhibition rates by 46.01% and 46.19%; reduce the activity of PPO enzyme and increase the inhibition rate of PPO enzyme activity by 35.58%; maintain a high total phenolic content, increasing the total phenolic content of pomegranate juice by 29.27% and 33.79%, respectively; and improve the ABTS scavenging rates by 2.89% and 1.92%, and increase DPPH scavenging rates by 1.35% and 3.01%. Moreover, vacuum ultrasound treatment had no significant effect on the odor of pomegranate juice. Vacuum combined with ultrasonic treatment is beneficial for protecting the color of pomegranate juice and improving its antioxidant performance during the processing. Therefore, combined technology of vacuum and ultrasound would be a promising method for future food processing.Practical applicationsThis study provides a simple and novel method for protecting the color of pomegranate juice during processing. The combination of vacuum and ultrasound has a certain protective effect on the color of pomegranate juice during processing, and also provides new ideas for color protection research.
Insights from user experience and evaluation of a mobile health nutrition intervention for children with autism: A qualitative study
Authors: Slater Courtney N. , Schroeder Krista , Fultz Amanda , Kuschner Emily S. , O'Malley Lauren , Johnson Kelsey , Benvenuti Teresa , Chittams Jesse , Quinn Ryan J. , Graham Thomas J. , Pinto‐Martin Jennifer , Levy Susan E. , Kral Tanja V. E. 
Published: September 2024

AbstractBackgroundChildren with autism spectrum disorder (ASD) experience high rates of atypical eating behaviours, such as food neophobia. Mobile health (mHealth) interventions have been found to improve communication, behaviour and social skills for children with ASD. However, there is limited evidence examining mHealth nutrition interventions among children with ASD.MethodsThe present study comprised a qualitative descriptive study that used qualitative content analysis to explore parent and child experiences with a novel mHealth nutrition intervention. Ten parent–child dyads provided user feedback and evaluation of the intervention. Data collection tools included a semistructured interview guide and a quantitative questionnaire with open‐ended questions. Data analysis of the interview transcripts and open‐ended questionnaire responses was an iterative process that continued until saturation was achieved. Descriptive statistics were used to analyse quantitative questionnaire data.ResultsAnalysis of the qualitative semistructured interviews led to emergence of three themes: (1) positive intervention outcomes; (2) parent suggestions for improvement; and (3) barriers to engagement. Each theme included subthemes. Questionnaire data revealed the ability to pick rewards and the virtual character that reinforced dietary goals (“Nutrition Ninja”) were the most liked components of the application. Sending messages within the application and the Nutrition Ninja game were the least liked components of the application.ConclusionsCollectively, findings indicated that the app served as an interactive tool prompting dietary change and conversations within families. Yet, for some families, the intervention design, resistance to change or child disinterest hindered use and implementation of the intervention.
Diffuse Large B‐Cell Lymphoma in a Cynomolgus Monkey
Authors: Li Heling , Zhang Long , Chen Zhigang , Zong Faliang , Tian Baohong , Chen Xinglong , Liu Deli , Ning Qing , Wang Hong 
Published: September 2024

ABSTRACTA captive 17‐year‐old male cynomolgus monkey (Macaca fascicularis) developed diffuse large B‐cell lymphoma (DLBCL). This was the first report of DLBCL presenting with a mandible mass and violation of the paranasal sinus in a cynomolgus monkey. The neoplasm showed marked microscopical malignant aspects. Immunohistochemical staining showed strong positive expression of CD20. These features may contribute to the diagnosis and therapeutics of DLBCL in NHPs.
Luteinizing hormone supplementation with human menopausal gonadotropin versus low dose human chorionic gonadotropin during ovarian stimulation does not affect live birth rates after fresh and frozen embryo transfer
Authors: Fischer Linnea , Chung Rebecca K. , Kim Sung Tae , Flyckt Rebecca , Weinerman Rachel 
Published: September 2024

AbstractAimLuteinizing hormone (LH) plays an important role in ovarian follicle maturation. Human menopausal gonadotropin (hMG) or low dose human chorionic gonadotropin (hCG) can provide LH supplementation during in vitro fertilization (IVF) ovarian stimulation, though studies directly comparing their impact on IVF outcomes are limited. The aim of the study was to determine whether LH supplementation with hMG versus low dose hCG during IVF stimulation affects live birth rate.MethodsFresh and frozen embryo transfers (ET) from 2017 to 2021 after standard long or antagonist protocols supplemented with hMG (75–250 IU) or low dose hCG (50–100 IU) during stimulation cycles in our academic center were included. Statistical analysis was performed with T‐tests, Mann–Whitney U tests, Chi‐square, and multiple linear and logistic regression.ResultsFour hundred and sixty eight unique stimulation cycles resulting in 213 fresh and 412 frozen embryo transfers were analyzed. There was a lower mature oocyte yield (10.9 vs. 11.8, p = 0.044) but similar high‐quality blastocyst yield (3.6 vs. 3.9, p = 0.11) for hMG vs low dose hCG. Live birth rates per transfer were comparable for fresh (42% vs. 49%, p = 0.24) and frozen (46% vs. 53%, p = 0.45) embryo transfers. Multiple logistic regressions showed no association between supplemental gonadotropin and live birth for both fresh and frozen embryo transfers.ConclusionFresh and frozen IVF‐ET pregnancy outcomes were comparable after hMG versus low dose hCG supplementation, suggesting flexibility in supplemental LH dosing regimens that may address patient or physician preference or cost concerns.
Insurtech, sensor data, and changes in customers' coverage choices: Evidence from usage‐based automobile insurance
Authors: Soleymanian Miremad , Weinberg Charles B. , Zhu Ting 
Published: September 2024

AbstractIn this paper, we examine the role of usage‐based auto insurance on customers' decisions to change their insurance coverage at the renewal. Using a sample of 135,540 customers, we study whether usage‐based insurance (UBI) can facilitate the upselling and cross‐selling efforts of the firm, possibly leading to higher coverage choices and additional insurance product purchases. Our results suggest that UBI customers are more likely to change their coverage choice than non‐UBI customers at first (but not second) renewal. Both price discounts and the information provided by UBI affect the customers' coverage changes. Among UBI customers, those who get higher UBI discounts are more likely to both increase their insurance coverage (upselling) and add the comprehensive coverage option (cross‐selling), which is not directly related to driving behavior at the time of first (annual) renewal. Moreover, customers who have received more negative feedback (daily hard brakes) are more likely to increase their insurance coverage.
Long‐term clinical outcomes of healthy dogs with increased alanine aminotransferase
Authors: Adams J. 
Published: September 2024

ObjectivesTo define a reference interval for alanine aminotransferase for the practice laboratory and then identify and longitudinally follow the clinical health and alanine aminotransferase levels in a cohort of clinically healthy dogs with increased alanine aminotransferase levels documented during wellness screening.Materials and MethodsAlanine aminotransferase levels of 125 clinically healthy dogs were used to define a reference interval for the practice laboratory. The electronic records of 315 clinically healthy dogs which had undergone wellness screening including assessment of alanine aminotransferase levels at a first‐opinion veterinary hospital in the UK were reviewed between January 2012 and January 2023. Clinically healthy dogs with increased alanine aminotransferase levels relative to the top of the reference interval determined for the practice on at least one test during the study period were identified. These were longitudinally followed through electronic medical records to determine their long‐term clinical outcomes over a period of up to 11 years.ResultsThe reference interval for alanine aminotransferase in the practice laboratory was calculated as 10.6 to 181.8 U/L. Nineteen clinically healthy dogs were identified as having increased alanine aminotransferase levels. One dog from the group with increased alanine aminotransferase levels was diagnosed with chronic hepatitis and died of liver failure, while the other 18 dogs died of other causes, or were still alive at the end of the study, with no clinical signs associated with liver disease. One dog in the group with consistently normal alanine aminotransferase levels also died from clinical signs attributed to liver disease.Clinical SignificanceOnly a small proportion of clinically healthy dogs with increased alanine aminotransferase levels documented on wellness screening developed clinically relevant liver dysfunction over long‐term follow‐up.
Population genomics of seal lice provides insights into the postglacial history of northern European seals
Authors: Sromek Ludmila , Johnson Kevin P. , Kunnasranta Mervi , Ylinen Eeva , Virrueta Herrera Stephany , Andrievskaya Elena , Alexeev Vyacheslav , Rusinek Olga , Rosing‐Asvid Aqqalu , Nyman Tommi 
Published: September 2024

AbstractGenetic analyses of host‐specific parasites can elucidate the evolutionary histories and biological features of their hosts. Here, we used population‐genomic analyses of ectoparasitic seal lice (Echinophthirius horridus) to shed light on the postglacial history of seals in the Arctic Ocean and the Baltic Sea region. One key question was the enigmatic origin of relict landlocked ringed seal populations in lakes Saimaa and Ladoga in northern Europe. We found that that lice of four postglacially diverged subspecies of the ringed seal (Pusa hispida) and Baltic gray seal (Halichoerus grypus), like their hosts, form genetically differentiated entities. Using coalescent‐based demographic inference, we show that the sequence of divergences of the louse populations is consistent with the geological history of lake formation. In addition, local effective population sizes of the lice are generally proportional to the census sizes of their respective seal host populations. Genome‐based reconstructions of long‐term effective population sizes revealed clear differences among louse populations associated with gray versus ringed seals, with apparent links to Pleistocene and Holocene climatic variation as well as to the isolation histories of ringed seal subspecies. Interestingly, our analyses also revealed ancient gene flow between the lice of Baltic gray and ringed seals, suggesting that the distributions of Baltic seals overlapped to a greater extent in the past than is the case today. Taken together, our results demonstrate how genomic information from specialized parasites with higher mutation and substitution rates than their hosts can potentially illuminate finer scale population genetic patterns than similar data from their hosts.
Virtuous leadership: Ambiguities, challenges, and precedents
Authors: Haldane John 
Published: September 2024

AbstractVirtuous leadership is the focus of a growing body of academic literature but is little discussed by contemporary philosophers. Current treatments tend to over‐generalisation: assimilating diverse features to a few broad categories and applying simplified ethical theories. This essay argues that virtue and character education need to be keyed to specific activities, that “virtuous leadership” is in danger of being confused with extrinsic activism, and that the history of ethics in health care provides an instructive example of thinking ethically about practice. Questions commonly posed in the literature—What specific virtues are required for leadership? How may these be formed?—are unduly simple and often rest on faulty assumptions about the nature of leadership and of the structure of virtuous action. Philosophers engaged in advising professionals about the virtues of leadership would do well to consider how the relevant points apply to their own practice.
Does the subjective response during the measurement of fusional reserves affect the clinical diagnosis?
Authors: Rovira‐Gay Cristina , Argilés Marc , Mestre Clara , Vinuela‐Navarro Valldeflors , Pujol Jaume 
Published: September 2024

AbstractIntroductionFusional reserves differ with the method of measurement. The goal of this study was to compare the subjective and objective responses during the measurement of positive and negative fusional reserves using both step and ramp methods.MethodsA haploscopic system was used to measure fusional reserves. Eye movements were recorded using an EyeLink 1000 Plus eye tracker (SR Research). The stimulus disparity was changed to either mimic a prism bar (steps) or a Risley prism (ramp). Subjective responses were obtained by pressing a key on the keyboard, whereas objective break and recovery points were determined offline using a custom algorithm coded in Matlab.ResultsThirty‐three adults participated in this study. For the ramp method, the subjective and objective responses were similar for the negative (break and recovery points (t(32) = −0.82, p = 0.42) and (t(32) = 0.42, p = 0.67), respectively) and positive fusional reserves (break and recovery points (U = −1.34, p = 0.18) and t(19) = −0.25, p = 0.81), respectively). For the step method, no significant differences in positive fusional reserves were observed when measured subjectively and objectively for the break (t(32) = 1.27, p = 0.21) or the recovery point (U = −2.02, Bonferroni‐adjusted p = 0.04). For the negative fusional reserve, differences were not significant for either the break or recovery points (U = −0.10, p = 0.92 and t(19) = 1.17, p = 0.26, respectively).ConclusionSubjective and objective responses exhibited good agreement when measured with the ramp and step methods.
Etiologies of atrioventricular block in young patients: A single‐center study in China
Authors: Zheng Jianhong , Chen Xin , Luo Guanhao , Zhang Qianhuan , Liao Hongtao , Deng Hai , Fang Xianhong , Xue Yumei , Liu Yang , Wu Shulin 
Published: September 2024

AbstractBackgroundAtrioventricular block (AVB) is common in the elderly and therefore considered to be a degenerative disease of the cardiac conduction system. However, there exist other etiologies contributing to AVB in young patients. This study aimed to determine the etiologies in patients aged before 60 years receiving their first pacemaker implantation for AVB in China.Methods and ResultsMedical records and diagnostic tests of AVB patients were reviewed to identify the etiologies between 2010 and 2021 at Guangdong Provincial People's Hospital. Eight hundred and twenty‐six patients (median age 47 years; 47.9% males) were included. The etiologies were identified in 336 (40.7%) cases, including complications to cardiac surgery (n = 190 [23.0%]), myocarditis (n = 57 [6.9%]), myocardial infarction (n = 25 [3.0%]), complications to catheter‐based interventional procedures (n = 21 [2.5%]) and others (n = 43 [5.2%]). AVB caused by myocardial infarction was more common in men (5.8% vs. 0.5%, p < .001), while women received pacing treatment earlier (48 vs. 46 years, p = .019). Men were more likely to suffer from dilated cardiomyopathy (6.6% vs. 2.1%, p = .001) and atrial fibrillation/flutter (23.0% vs. 12.8%, p < .001). The number of first pacemaker implantation increased with age especially among patients with unclear etiologies.ConclusionThe etiology of AVB was only determined in approximately 40% of patients receiving their first pacemaker implantation aged before 60 years. The predominance of AVB with unknown etiology and potential gender differences warrants further studies.
Coronary sinus signal amplitude: A predictor of the atrial substrate and low voltage areas
Authors: Mohsen Yazan , Großmann Nora , Draheim Jennifer , Horlitz Marc , Stöckigt Florian 
Published: September 2024

AbstractBackgroundLow voltage areas (LVA) are pivotal in atrial fibrillation (AF) pathogenesis, influencing local left atrial LA excitation and perpetuating AF occurrences. While pulmonary vein isolation (PVI) with cryo‐balloon (CB) ablation is effective for AF, it doesn't provide insights into the LA substrate or detect LVA, which affects ablation success rates. This study examines whether LA voltage and LVAs can be anticipated by analyzing the voltage signal amplitude at the coronary sinus (CS) catheter, which is standard in CB and radiofrequency ablation procedures.MethodsA retrospective analysis of 284 patients with recurrent AF undergoing RF catheter ablation was conducted at a high‐volume EP center in Germany. The correlation between LA voltage and LVA with the CS signal was explored.ResultsThe signal amplitude in the CS significantly correlated with voltage in LA walls, particularly in the proximal CS (correlation coefficient ρ = 0.81, p < 0.001). A CS signal cut‐off of 1.155 mV effectively predicted severe atrial LVAs (>40%) with a sensitivity of 90.7% and a specificity of 100%. While a threshold of 1.945 mV identified patients with no significant atrial LVAs (<5%) with a sensitivity of 88% and a specificity of 50% (AUC: 0.81, 95% CI: 0.71–0.89, p < 0.001).ConclusionThe CS signal amplitude is associated with the LA voltage. Due to its potential as a diagnostic tool for atrial LVAs, the signal amplitude in the CS could provide valuable information about the LA substrate, especially when 3D mapping is not feasible.