bluuebunny/crossref_metadata_2025_split huggingface dataset:
IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells
Authors: Clancy-Thompson Eleanor , Ali Lestat , Bruck Patrick T. , Exley Mark A. , Blumberg Richard S. , Dranoff Glenn , Dougan Michael , Dougan Stephanie K. 
Published: November 2017

Abstract
Inhibitor of apoptosis protein (IAP) antagonists are in clinical trials for a variety of cancers, and mouse models show synergism between IAP antagonists and anti–PD-1 immunotherapy. Although IAP antagonists affect the intrinsic signaling of tumor cells, their most pronounced effects are on immune cells and the generation of antitumor immunity. Here, we examined the effects of IAP antagonism on T-cell development using mouse fetal thymic organ culture and observed a selective loss of iNKT cells, an effector cell type of potential importance for cancer immunotherapy. Thymic iNKT-cell development probably failed due to increased strength of TCR signal leading to negative selection, given that mature iNKT cells treated with IAP antagonists were not depleted, but had enhanced cytokine production in both mouse and human ex vivo cultures. Consistent with this, mature mouse primary iNKT cells and iNKT hybridomas increased production of effector cytokines in the presence of IAP antagonists. In vivo administration of IAP antagonists and α-GalCer resulted in increased IFNγ and IL-2 production from iNKT cells and decreased tumor burden in a mouse model of melanoma lung metastasis. Human iNKT cells also proliferated and increased IFNγ production dramatically in the presence of IAP antagonists, demonstrating the utility of these compounds in adoptive therapy of iNKT cells. Cancer Immunol Res; 6(1); 25–35. ©2017 AACR.
Petrografia e litoquímica de rochas ferríferas na região central do estado do Rio Grande do Norte (Domínio Rio Piranhas – Seridó, NE da Província Borborema)
Authors: Dantas Alexandre Ranier , Nascimento Marcos Antônio Leite do , Costa Alan Pereira da , Cavalcante Rogério 
Published: November 2017

As ocorrências de rochas ferríferas no estado do Rio Grande do Norte correspondem essencialmente a pequenos depósitos que aparentemente não apresentam potencial econômico. Porém, pequenos jazimentos desse bem mineral têm sido explotados em algumas áreas dessa região. As formações ferríferas ocorrem como intercalações decimétricas a algumas dezenas de metros em gnaisses da Formação Jucurutu e menos frequentemente estão associadas às rochas metamáficas encaixadas em gnaisses do Complexo Caicó. Neste trabalho, é apresentada uma caracterização petrográfica macro e microscópica de rochas ferríferas, além da discussão dos dados de litoquímica e uso de MEV-EDS para estudo da composição química qualitativa de magnetitas e anfibólios. Essas rochas normalmente apresentam teores de Fe2O3 variando entre 46 e 59% e de SiO2 entre 33 e 50%. Petrograficamente, foram identificados dois grupos distintos: rochas ferríferas granulares e rochas ferríferas bandadas. A litoquímica permitiu concluir que os grupos de rochas estudadas apresentam comportamentos ora similares, ora distintos. São rochas compostas essencialmente de Si e Fe, com pequena proporção de elementos-traço e terras raras. Os parâmetros químicos indicam ambiente dominantemente oxidante e grupos de rochas em posições intermediárias a mais próximas das fontes hidrotermais oceânicas. Os ambientes tectônicos para formação das rochas ferríferas granulares e bandadas estudadas indicam principalmente cadeias oceânicas localizadas nas imediações de margens continentais ativas transicionais a arco de ilhas.
Petrografia e geoquímica de gnaisses da região de Indiara, porção central do arco magmático de Goiás
Authors: Navarro Guillermo Rafael Beltran , Zanardo Antenor , Montibeller Cibele Carolina , Conceição Fabiano Tomazini da , Valeriano Claudio de Morisson 
Published: November 2017

Na região de Indiara, Goiás, ocorre uma extensa faixa de gnaisses relacionados ao Arco Magmático de Goiás, próximo ao contato com as rochas supracrustais da Sequência Metavulcanossedimentar Anicuns-Itaberaí. Dados geoquímicos e isotópicos (Sm/Nd) mostram que os gnaisses da região de Indiara não são semelhantes às rochas de regiões tipo do Arco Magmático de Goiás (regiões de Arenópolis, Firminópolis, Iporá e Mara Rosa). São rochas cálcio-alcalinas e peraluminosas, com composição predominantemente granítica, em contraste com o caráter prevalentemente cálcico e metaluminoso das regiões tipo, que também apresentam composição dominantemente tonalítica a granodiorítica. Os altos teores de SiO2, o caráter fortemente peraluminoso e os altos teores de coríndon normativo sugerem que os gnaisses da região de Indiara são derivados de granitos tipo-Sin-colisionais e/ou correspondem à mistura de protólitos ígneos e sedimentares. As idades modelo TDM (1,88 e 1,90 Ga) sugerem que os gnaisses da região evoluíram de crosta siálica mais antiga do que as rochas que compõem o Arco Magmático de Goiás.
International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM)
Authors: O’Mahony Constantinos , Jichi Fatima , Ommen Steve R. , Christiaans Imke , Arbustini Eloisa , Garcia-Pavia Pablo , Cecchi Franco , Olivotto Iacopo , Kitaoka Hiroaki , Gotsman Israel , Carr-White Gerald , Mogensen Jens , Antoniades Loizos , Mohiddin Saidi A. , Maurer Mathew S. , Tang Hak Chiaw , Geske Jeffrey B. , Siontis Konstantinos C. , Mahmoud Karim D. , Vermeer Alexa , Wilde Arthur , Favalli Valentina , Guttmann Oliver P. , Gallego-Delgado Maria , Dominguez Fernando , Tanini Ilaria , Kubo Toru , Keren Andre , Bueser Teofila , Waters Sarah , Issa Issa F. , Malcolmson James , Burns Tom , Sekhri Neha , Hoeger Christopher W. , Omar Rumana Z. , Elliott Perry M. 
Published: November 2017

Background:
Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk of sudden cardiac death (SCD) and require a prophylactic implantable cardioverter defibrillator is challenging. In 2014, the European Society of Cardiology proposed a new risk stratification method based on a risk prediction model (HCM Risk-SCD) that estimates the 5-year risk of SCD. The aim was to externally validate the 2014 European Society of Cardiology recommendations in a geographically diverse cohort of patients recruited from the United States, Europe, the Middle East, and Asia.

Methods:
This was an observational, retrospective, longitudinal cohort study.

Results:
The cohort consisted of 3703 patients. Seventy three (2%) patients reached the SCD end point within 5 years of follow-up (5-year incidence, 2.4% [95% confidence interval {CI}, 1.9–3.0]). The validation study revealed a calibration slope of 1.02 (95% CI, 0.93–1.12), C-index of 0.70 (95% CI, 0.68–0.72), and D-statistic of 1.17 (95% CI, 1.05–1.29). In a complete case analysis (n= 2147; 44 SCD end points at 5 years), patients with a predicted 5-year risk of <4% (n=1524; 71%) had an observed 5-year SCD incidence of 1.4% (95% CI, 0.8–2.2); patients with a predicted risk of ≥6% (n=297; 14%) had an observed SCD incidence of 8.9% (95% CI, 5.96–13.1) at 5 years. For every 13 (297/23) implantable cardioverter defibrillator implantations in patients with an estimated 5-year SCD risk ≥6%, 1 patient can potentially be saved from SCD.

Conclusions:
This study confirms that the HCM Risk-SCD model provides accurate prognostic information that can be used to target implantable cardioverter defibrillator therapy in patients at the highest risk of SCD.
High Incidence of Atrial Fibrillation After Embolic Stroke of Undetermined Source in Posterior Cerebral Artery Territory
Authors: Makimoto Hisaki , Kurt Muhammed , Gliem Michael , Lee John‐Ih , Schmidt Jan , Müller Patrick , Clasen Lukas , Brinkmeyer Christoph , Shin Dong‐In , Jander Sebastian , Kelm Malte , Fürnkranz Alexander 
Published: November 2017

Background

Subclinical atrial fibrillation is one possible cause of embolic stroke of undetermined source (
ESUS
). It remains to be elucidated if a specific infarction site has a predictive value for detecting subclinical atrial fibrillation. We aimed to investigate the predictive value of infarction site in patients with ESUS for the detection of atrial tachyarrhythmia (
AT
) using an insertable cardiac monitor.

Methods and Results

Consecutive 146 patients (84 men; aged 62±12 years) underwent insertable cardiac monitor implantation after diagnosis of
ESUS
. The detection of
AT
>30 seconds was evaluated. The ESUS infarction sites were categorized into internal carotid artery and vertebral artery (
VA
) territories, with ophthalmic artery, anterior cerebral artery, and middle cerebral artery as internal carotid artery subterritories, and posterior cerebral artery and other vertebrobasilar arteries as
VA
subterritories. During a median follow‐up of 387 days,
AT
was detected in 33 patients (23%). Subclinical
AT
detection was significantly more frequent after
VA
territorial infarction opposed to internal carotid artery infarction (20/57 [35%] versus 13/89 [15%];
P
=0.0039). Kaplan‐Meier analysis demonstrated a significantly higher
AT
detection rate after
VA
infarction (log‐rank,
P
=0.0076). Regression analysis revealed that
VA
territorial infarction, and particularly posterior cerebral artery area infarction, was an independent predictor of
AT
detection.

Conclusions

Patients with
ESUS
in the posterior cerebral artery territory had a higher rate of subclinical
AT
detection than those with other infarct localizations. Our data suggest that the possible usefulness of
ESUS
site to identify candidates for direct oral anticoagulation should be confirmed in future research.
Creative and Lucrative Daʿwa: The Visual Culture of Instagram amongst Female Muslim Youth in Indonesia
Authors: Nisa Eva F. 
Published: November 2017

Abstract
Social media have become part of the private and public lifestyles of youth globally. Drawing on both online and offline research in Indonesia, this article focuses on the use of Instagram by Indonesian Muslim youth. It analyzes how religious messages uploaded on Instagram through posts and captions have a significant effect on the way in which Indonesian Muslim youth understand their religion and accentuate their (pious) identities and life goals. This article argues that Instagram has recently become the ultimate platform for Indonesian female Muslim youth to educate each other in becoming virtuous Muslims. The creativity and zeal of the creators of Instagram daʿwa (proselytization), and their firm belief that ‘a picture is worth a thousand words’, has positioned them as social media influencers, which in turn has enabled them to conduct both soft daʿwa and lucrative daʿwa through business.
Of Ladies and Lesbians and Books on Women from the Third/Ninth and Fourth/Tenth Centuries
Authors: Myrne Pernilla 
Published: November 2017

AbstractInformation about women in Abbasid society — and especially the subgroups ofmutaẓarrifāt, ladies, andsaḥḥaqāt, lesbians — is gathered from two extant sources that explicitly deal with the subject:al-Muwashshā, “The Painted Cloth,” by al-Washshāʾ (d. 325/936-7) andJawāmiʿ al-ladhdha, composed some fifty years later by ʿAlī b. Naṣr al-Kātib. TheJawāmiʿ al-ladhdhais an erotic compendium that relies heavily on earlier sources,al-Muwashshāincluded; however, most of the works cited are lost. A survey of book-titles from the same period indicates that a good many books about women were written at the time. Representations of ladies and lesbians as they appear from the two sources and surveyed lists of book-titles suggest a complex picture of the lady-lesbian that changed over time. That some of the books dealing with the subject were still available some six-hundred years later shows that the erotic lore of the Abbasids continued to arouse interest for centuries.
The South Georgia Wave Experiment: A Means for Improved Analysis of Gravity Waves and Low-Level Wind Impacts Generated from Mountainous Islands
Authors: Jackson D. R. , Gadian A. , Hindley N. P. , Hoffmann L. , Hughes J. , King J. , Moffat-Griffin T. , Moss A. C. , Ross A. N. , Vosper S. B. , Wright C. J. , Mitchell N. J. 
Published: November 2017

AbstractGravity waves (GWs) play an important role in many atmospheric processes. However, the observation-based understanding of GWs is limited, and representing them in numerical models is difficult. Recent studies show that small islands can be intense sources of GWs, with climatologically significant effects on the atmospheric circulation. South Georgia, in the South Atlantic, is a notable source of such “small island” waves. GWs are usually too small scale to be resolved by current models, so their effects are represented approximately using resolved model fields (parameterization). However, the small-island waves are not well represented by such parameterizations, and the explicit representation of GWs in very-high-resolution models is still in its infancy. Steep islands such as South Georgia are also known to generate low-level wakes, affecting the flow hundreds of kilometers downwind. These wakes are also poorly represented in models.We present results from the South Georgia Wave Experiment (SG-WEX) for 5 July 2015. Analysis of GWs from satellite observations is augmented by radiosonde observations made from South Georgia. Simulations were also made using high-resolution configurations of the Met Office Unified Model (UM). Comparison with observations indicates that the UM performs well for this case, with realistic representation of GW patterns and low-level wakes. Examination of a longer simulation period suggests that the wakes generally are well represented by the model. The realism of these simulations suggests they can be used to develop parameterizations for use at coarser model resolutions.
Dynamic and Thermodynamic Impacts of the Winter Arctic Oscillation on Summer Sea Ice Extent
Authors: Park Hyo-Seok , Stewart Andrew L. , Son Jun-Hyeok 
Published: November 2017

AbstractArctic summer sea ice extent exhibits substantial interannual variability, as is highlighted by the remarkable recovery in sea ice extent in 2013 following the record minimum in the summer of 2012. Here, the mechanism via which Arctic Oscillation (AO)-induced ice thickness changes impact summer sea ice is explored, using observations and reanalysis data. A positive AO weakens the basin-scale anticyclonic sea ice drift and decreases the winter ice thickness by 15 and 10 cm in the Eurasian and the Pacific sectors of the Arctic, respectively. Three reanalysis datasets show that the upward surface heat fluxes are reduced over wide areas of the Arctic, suppressing the ice growth during the positive AO winters. The winter dynamic and thermodynamic thinning preconditions the ice for enhanced radiative forcing via the ice–albedo feedback in late spring–summer, leading to an additional 10 cm of thinning over the Pacific sector of the Arctic. Because of these winter AO-induced dynamic and thermodynamics effects, the winter AO explains about 22% (r = −0.48) of the interannual variance of September sea ice extent from 1980 to 2015.
Exercise for Cognitive Symptoms in Depression: A Systematic Review of Interventional Studies
Authors: Sun Meng , Lanctot Krista , Herrmann Nathan , Gallagher Damien 
Published: November 2017

Objective: To explore the effect of exercise on cognition in depression as well as the impact of potential moderators and intervention type. Method: Controlled and uncontrolled interventional studies that described an exercise intervention and cognitive outcomes in participants with major depressive disorder (MDD) were included following a search of Pubmed, Ovid Medline, PsycInfo and Embase from inception to January 2017. Meta-analyses were conducted to calculate Hedges’ g using a random-effects model. Meta-regression explored the relationships among age, baseline cognition, frequency and duration of exercise, and cognitive outcomes. Subgroup analyses were also conducted according to type and intensity of exercise interventions. Results: Of 12 controlled studies and 3 uncontrolled studies that met inclusion criteria, 9 (642 patients) were included in the meta-analysis. No significant effect of exercise was found on global cognition (Hedges’ g = 0.08, P = 0.33, I2 = 0%) or on individual cognitive domains. Meta-regression analyses failed to find significant relationships among participant age, baseline cognition, number of exercise sessions per wk, duration of exercise per wk, total duration of exercise during the intervention, or improvement in global cognition. Interventions combining physical with cognitive activity significantly improved global cognition ( P = 0.048), whereas low-intensity interventions were also positive ( P = 0.048). Conclusions: No impact of physical exercise was found on cognition in MDD overall. However, we found that interventions combining physical and cognitive activities had a positive impact, and that lower-intensity interventions, where adherence was improved, also impacted positively. There remains a lack of high-quality data in this population.
Profil neuropsychologique et mémoire de travail dans le trouble bipolaire
Authors: Coppola Frédéric , Courtet Philippe , Olié Emilie 
Published: November 2017

Selon l’Organisation Mondiale de la Santé (OMS), le trouble bipolaire fait partie des dix maladies les plus couteuses et invalidantes sur le plan mondial. La prise en charge habituelle de cette pathologie comprend un suivi psychiatrique dont la fréquence est adaptée à l’état thymique, et la mise en place d’un traitement thymorégulateur. Toutefois, le devenir des patients atteints de trouble bipolaire reste insatisfaisant. Les répercussions psychosociales, majorées par la présence fréquente de comorbidités somatiques et psychiatriques sont importantes (Bonnin et al., 2010) et peuvent être invalidantes: désinsertion socioprofessionnelle, isolement social, retentissement familial, bas niveau socio-économique, moindre qualité de vie. Une altération fonctionnelle est ainsi retrouvée lors des phases de décompensations aigues, mais également en période intercritique où différents facteurs peuvent être impliqués: symptomatologie résiduelle thymique ou cognitive, comme conséquences des épisodes, présence de comorbidités…En effet, 30% des patients bipolaires présentent pendant cette phase de la maladie des déficits cognitifs, objectivables par des tests neuropsychologiques (Gualtieri and Morgan, 2008). Près de deux tiers présentent des plaintes cognitives subjectives (Martinez-Aran et al., 2005) qui sont négativement corrélées avec la qualité de vie. Parmi ces déficits, l’atteinte de la mémoire de travail est rapportée par plusieurs études (Bora et al., 2009; Robinson et al., 2006), et semble jouer un rôle important dans le handicap fonctionnel. Prendre en charge les troubles cognitifs semble être un enjeu important afin d’améliorer le fonctionnement, la qualité de vie du patient ainsi que la stabilité du trouble. Cependant, les techniques de remédiation cognitive, largement développées pour les patients atteints de schizophrénie, restent limitées dans le trouble bipolaire, malgré l’impact majeur des déficits cognitifs dans ce trouble. L’objectif de cet article est de faire le point sur le profil neuropsychologique du patient bipolaire en période intercritique, en mettant en avant le rôle prépondérant de la mémoire de travail dans le handicap fonctionnel. Nous discuterons également des avancées thérapeutiques actuelles permettant de prendre en charge ces déficits et améliorer le fonctionnement du patient.
Caring for Dying Patient and Their Families
Authors: Garrino Lorenza , Contratto Claudia , Massariello Patrizia , Dimonte Valerio 
Published: November 2017

Background: The literature from recent decades persistently suggests that nurses are not adequately trained in caring for the dying. Numerous studies call for enhanced education in end-of-life care. Objective: To explore student nurses’ experience of caring for dying persons and their families and how this experience was influenced by their undergraduate education, with a view to improving end-of-life training. Methods: Narrative interviews were administered to a purposive sample of 18 undergraduate students at Turin University’s School of Nursing and analyzed following Giorgi’s qualitative phenomenological methodology. Results: The students’ accounts featured 4 main themes: emotions and feelings, reactions and coping strategies, growth in personal and professional awareness, and the professional nursing model. Students reporting positive experience of end-of-life care in clinical settings displayed the expected learning outcomes for undergraduate nursing education. Conclusion: This study’s strength lies in the fact that it draws on student nurses’ lived experience to assess training in end-of-life care. It confirms the need to invest in targeted end-of-life education and support for nursing students.
Healthy Immigrant Families: Randomized Controlled Trial of a Family-Based Nutrition and Physical Activity Intervention
Authors: Wieland Mark L. , Hanza Marcelo M. M. , Weis Jennifer A. , Meiers Sonja J. , Patten Christi A. , Clark Matthew M. , Sloan Jeff A. , Novotny Paul J. , Njeru Jane W. , Abbenyi Adeline , Levine James A. , Goodson Miriam , Capetillo Graciela D. Porraz , Osman Ahmed , Hared Abdullah , Nigon Julie A. , Sia Irene G. 
Published: November 2017

Purpose: To evaluate a healthy eating and physical activity intervention for immigrant families, derived through community-based participatory research. Design: The Healthy Immigrant Families study was a randomized controlled trial with delayed intervention control group, with families as the randomization unit. Setting: US Midwest city. Participants: Participants were recruited by community partners from Hispanic, Somali, and Sudanese immigrant communities. Intervention: Family health promoters from participating communities delivered 6 healthy eating modules, 4 physical activity modules, and 2 modules synthesizing information in 12 home visits (60-90 minutes) within the first 6 months. Up to 12 follow-up phone calls to each participant occurred within the second 6 months. Measures: Primary measures were dietary quality measured with weekday 24-hour recall and reported as Healthy Eating Index score (0-100) and physical activity measured with accelerometers (14 wear days) at baseline, 6, 12, and 24 months. Results: In total, 151 persons (81 adolescents and 70 adults; 44 families) were randomly assigned. At 12 months, significant improvement occurred in Healthy Eating Index scores for adults in the intervention group compared with controls (change, +8.6 vs −4.4; P < .01) and persisted at 24 months (+7.4 from baseline; P < .01). No differences were observed for adolescents and no significant differences occurred between groups for physical activity. Conclusion: This intervention produced sustained dietary quality improvement among adults but not among adolescents. Program outcomes are relevant to communities working to decrease cardiovascular risk among immigrant populations.