bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of language‐sensitive subject teaching: Heterogeneity and quality of the evidence and implications for future research
Authors: Vasylyeva Tetyana , Woerfel Till , Twente Leonie , Höfler Martha 
Published: September 2024

AbstractWe report and appraise the heterogeneity and quality of 53 primary studies included in a systematic review project on the effectiveness of language‐sensitive subject teaching in primary and secondary education to provide a comprehensive overview of the research field and to give detailed recommendations for future research. We followed a systematic review process adhering to existing guidelines and procedures to define inclusion and quality criteria for experimental, quasi‐experimental and observational studies published since 1990 in English and German. We performed an extensive search, screened on titles, abstracts and full texts, and found 55 studies to meet the inclusion criteria. Out of these studies, 53 studies fulfilled the quality criteria (assessment of internal validity) and were included in the review. Most of the studies show that students taught with language‐sensitive approaches achieve the same or better results than students taught using non‐language‐sensitive approaches for at least one content or language learning outcome (for the results of the narrative synthesis, see Höfler et al., Zeitschrift für Erziehungswissenschaft, 2023, 27, 449). Here, we examine in detail the characteristics of the included studies in terms of the heterogeneity of populations, interventions, outcomes, and study designs and provide arguments for a careful interpretation of the review results. We argue that limited methodological and reporting quality introduce risk of bias to varying degrees. We address methodological issues and gaps in research and present our detailed recommendations for future work informed by our findings.
Context and implicationsRationale for this study: This paper systematises the heterogeneity, quality and scope of the studies on the effectiveness of language‐sensitive teaching and gives detailed recommendations for future research.Why the new findings matter: Our findings help shape the trajectory of research on language‐sensitive subject teaching.Implications for researchers and policy makers: This article describes the state of knowledge concerning the effectiveness of language‐sensitive subject teaching. Our results provide educators and educational researchers with a systematised overview of the tested approaches and their effect on different learning outcomes. Based on our assessment of the study quality and the transferability of the results, we point out research gaps and offer detailed recommendations to help researchers design new research projects. Our results will also aid policy makers in deciding what evidence to consider in the context of evidence‐based practice as well as in the formulation of future funding directives.
Gender, social networks, and the use of organic fertilizers toward sustainable agriculture in suburban villages of Central Vietnam
Authors: Le Thi Quynh Anh , Shimamura Yasuharu , Yamada Hiroyuki , Le Minh Duc 
Published: September 2024

AbstractFarmland degradation caused by excessive use of agrochemicals is a serious environmental concern, and thus the use of organic fertilizers is encouraged for sustainable agriculture in Vietnam. However, the adoption of organic fertilizers among farming households has been slow, spontaneous, and fragmented. The absence of credible information and advisory sources is reported to be a critical constraint. The sharing of information and experiences among social networks is expected to play an important role in overcoming this constraint, although strong causal evidence remains scarce. Therefore, this study employs an instrumental variable approach with observational village‐census data to identify the causal impacts of social networks on the adoption of organic fertilizers and explores the underlying information‐sharing mechanism within social networks, providing rich information about existing social networks for both men and women separately. The estimation results show that in farming households, the wife's social networks have a positive and significant effect on the diffusion of organic fertilizers. Our findings highlight the role of information exchange, experience sharing, and agricultural collaboration among groups of women in enhancing pro‐environmental agricultural practices in suburban villages of Central Vietnam.
TiO2 and ZnO Nanoparticles Immobilized on Magnetic Sulfonated Melamine‐Formaldehyde: Structure Identification and Performance as Recyclable Catalysts for the Biginelli Reaction
Authors: Jamshidifard Kamran , Rezaei Ramin , Farsadrooh Majid , Rouhani Shamila 
Published: September 2024

AbstractSulfonated melamine‐formaldehyde (SMF) containing high dispersed TiO2 and ZnO nanoparticles were fabricated into magnetic nanocomposites by two different method material incorporation protocols, including calcination and wet impregnation. Their catalytic performance was investigated toward Biginelli reaction. For the preparation of the first catalyst series, a two‐step protocol was used. Initially, Fe3O4 nanoparticles were coated with SMF (Fe3O4/SMF). Subsequently, they were decorated consecutively with TiO2 (Fe3O4/SMF/TiO2) and ZnO (Fe3O4/SMF/ZnO). The second set of catalysts was prepared using a two‐step process. Fe3O4 nanoparticles were first used to modify SMF (SMF/Fe3O4). Following the initial step, the surface of SMF/Fe3O4 was decorated with both TiO2 (SMF/Fe3O4/TiO2) and ZnO (SMF/Fe3O4/ZnO). To understand the characteristics of the synthesized nanocomposites, a variety of characterization techniques were employed. New catalysts enabled the rapid synthesis (30–45 min) of a range of biologically active 3,4‐dihydropyrimidinones based on the Biginelli reaction with high yields (70–95 % isolated).
Linamarin Binding to Human Serum Albumin. A Spectroscopic and Molecular Docking Approach
Authors: Jelić Ratomir , Mrkalić Emina , Ćendić‐Serafinović Marina , Odović Jadranka , Sovrlić Miroslav 
Published: September 2024

AbstractThe interaction between linamarin (LIN), a cyanogenic glycoside, and human serum albumin (HSA) was studied by multiple spectroscopic techniques and molecular docking simulation. All measurements were performed under physiological conditions. The obtained results (including the binding constants, effective quenching constant and a number of binding sites) showed that the complex of HSA‐LIN is formed. The values of Stern‐Volmer constants (6.70×103, 5.53×103 and 1.95×103) indicate that fluorescence quenching of HSA was static. Results of site marker experiments showed that the binding site of LIN is mainly located in site I (subdomain IIA) of HSA. The thermodynamic parameters showed that binding process occurs spontaneously through hydrophobic interactions. Molecular docking results are in good agreement with experimental data. Furthermore, computational results revealed LIN binds in the cavity of TRP 214, that is, subdomain IIA (site I) of HSA. This comprehensive study provides a deeper insight into ligand binding in HSA which may be useful in drug design and pharmacology.
Fabrication of Famotidine Loaded Sepiolite/Pectin Bionanocomposite Hydrogels for Controlled Drug Delivery
Authors: Yasin Amina , Ahmad Sana , Imran Saleha 
Published: September 2024

AbstractDevelopment of drug delivery systems is an extensively researched area in the biomedical field. In recent years, there has been an increasing interest in fabrication of biocompatible nanofibrous drug delivery systems. The present study describes the fabrication of calcium chloride‐crosslinked bionanocomposite hydrogels based on pectin for the use of gastro‐retentive delivery system. Sepiolite/famotidine/pectin nanocomposite hydrogel was fabricated by using Ionotropic gelation process. The thermal, structural and morphological properties were evaluated via different experimental techniques such as TGA‐DSC, FTIR, and SEM. The prepared hydrogels showed a pH sensitive swelling profile with maximum water absorption at pH 1.2. Analysis of in‐vitro drug release data revealed that the sepiolite/famotidine/pectin nanocomposite hydrogels exhibited a slight initial burst release, followed by a sustained release over a 24 h period. This was observed both in simulated gastric fluid and in phosphate‐buffered saline, suggesting that these hydrogels are well‐suited for prolonged drug delivery. To investigate the drug release kinetics, various models were applied. The release of famotidine was predominantly governed by diffusion, as described by the Korsmeyer‐Peppas model.
In Vitro Activation of Paraoxonase 1 by Steroids: An Experimental, Molecular Docking, and Molecular Modelling Study
Authors: Deveci Ufuk , Çıkrıkcı Kübra , Kuru Ali , Yildirim Kudret , Muhammed Muhammed Tilahun , Gencer Nahit 
Published: September 2024

AbstractParaoxonase 1 (PON1) is an antioxidant enzyme that prevents lipid oxidation by hydrolysing lipid peroxides in the oxidised low‐density lipoprotein (LDL) structure, bound to high‐density lipoprotein (HDL) in serum, and exhibits esterase and lactonase activity. In this work, the hPON1 enzyme was purified from human serum using a hydrophobic gel with Sepharose 4B‐L‐tyrosine‐naphthylamine, and the affinity of some steroid derivatives previously isolated from fungal steroid biotransformations was examined on the pure hPON1 enzyme. The results indicate that all these derivaties activate the hPON1 enzyme to a different extent. Additionally, the binding potential of the most active five steroid derivatives to the PON1 enzyme to form a stable complex was explored through molecular docking and molecular dynamics (MD) simulation. The compounds with the highest potency in the enzymatic assay, S‐8 and S‐20, had the highest binding potential to the enzyme. The stability of the complexes formed by the two compounds was assessed and compared to the stability of the unbound enzyme structure. The enzyme‐compound complexes generally had similar stability to the unbound enzyme structure. Together with this, the MD simulation revealed that compound S‐8 would remain inside the enzyme's binding site during the simulation period, unlike compound S‐20. This situation varies according to the respective derivatives’ functional groups and hydrophobic characteristics.
Tunable Properties of New Cyano‐Substituent Heptahelicenes for Optoelectronic Devices: A Combined Experimental and DFT Computational Study
Authors: Hfaiedh Amira , Labiedh Makrem , Mabrouk Ali , Chemek Mourad , Ben Braiek Mourad , Alimi Kamel 
Published: September 2024

AbstractHere, we describe a set of coupled experimental and theoretical analyses. The introduction of one and two additional cyano groups in the carboheptahelicene backbone enhance its electron‐accepting properties. New carboheptahelicene derivatives are synthesized, and relevant characterizations of structural features, photophysical and electrochemical properties, and structure‐property relationships are described. This present work concerns the use of the density functional theory (DFT) to highlight the structural and the optoelectronic properties of carboheptahelicene derivatives and comparing the obtained findings with the experimental ones. The experimental and theoretical spectra (UV‐Vis absorption and photoluminescence) provide excellent concurrence. Afterward, molecular structures, structural parameters, molecular electrostatic potential (MEP), highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energies of frontier molecular orbitals (FMOs) are constructed. Some other optoelectronic parameter including electron affinity (EA), ionization potential (IP), and some reactive descriptor such as chemical potential (μ), global hardness (η), electronegativity (χ) and the overall electrophilicity index (ω) are determined and indicating its potential uses as an active layer in optoelectronic efficient devices. The topological methods such as electron localization function (ELF), localization orbital locator (LOL) and the reduced density gradient method (RDG) were also conducted to clarify the strengths and kinds of interactions.
Synthesis of Indenoindole Derivatives under Deep Eutectic Solvent Conditions
Authors: Kotha Sambasivarao , Salman Mohammad , Cheekatla Subba Rao 
Published: September 2024

AbstractIn this study, we synthesized a variety of indole derivatives using commercially available 2,5‐dimethoxybenzaldehyde 18 as a starting material. The synthetic route involves a sequential usage of Knoevenagel and Fischer indolization reactions as key steps and the Fischer indolization is facilitated by deep eutectic solvent (DES) such as L‐tartaric acid/dimethylurea (TA:DMU). All the compounds prepared here are characterized by HRMS, 1H‐NMR and 13C‐NMR data. The methodology described in this study showcases the utility of deep eutectic solvents in facilitating the synthesis of diverse indole derivatives, thereby expanding the toolkit of sustainable synthetic methodologies. These compounds are medicinally important and play a key role as an effective template in Kinase inhibitors (CK2). Various functionalized indeno[1,2‐b]indole scaffolds synthesized here might be valuable as novel inhibitors of human CK2. Elevated levels of protein kinase CK2, previously known as casein kinase 2 or II, have been linked to higher cell growth and proliferation in both normal and cancerous cells.
Mn‐functionalized ZIF‐67 for Sensitive Colorimetric Detection of Artemisinin and Ascorbic Acid
Authors: Wang Xinyi , Cheng Zihan , Liu Yuting , Wang Li , Chen Lili 
Published: September 2024

AbstractArtemisinin (Art) is the first‐choice medicine for treating malaria. It also shows good therapeutic effects in antibacterial and antitumor treatment. Therefore, a simple and efficient method for detecting Art is of great significance. Mn‐functionalized ZIF‐67 (Mn@ZIF‐67) hybrid materials were synthesized using a post‐synthesis modification method. Due to the introduction of Mn2+, Mn@ZIF‐67 possesses higher peroxidase/oxidase like dual‐mimic enzymes activity than ZIF‐67, which can catalyze Art and generate peroxyl radicals. Based on this fact, Mn@ZIF‐67 was used to detect Art in the presence of TMB. A good linear relationship between absorption intensities at 652 nm and Art concentrations was obtained in the range of 0–22 μM with a detection limit of 200 nM. Ascorbic acid (AA), due to its reducibility, can inhibit peroxidase/oxidase mimetics activity of Mn@ZIF‐67 and the blue Mn@ZIF‐67‐TMB solution fades gradually with the addition of AA. Mn@ZIF‐67‐TMB acting as a colorimetric sensor, AA can be sensitively detected ranging from 0–30 μM, and the detection limit is 50 nM. Coexisting substances don't interfere with the detection of Art or AA. This sensing platform provides a highly sensitive and selective colorimetric method for monitoring AA and Art in serum, thereby demonstrating remarkable practicality.
Nickel Nanoparticles as a Sustainable Catalyst for the Synthesis of 2H‐Pyran Derivatives under Microwave Irradiation, and their Anti‐Inflammatory Activity
Authors: Elkanzi Nadia A. A. , Saber El Sayed A. , Ali Ali M. , Alali Ibtisam , Hrichi Hajer , Muqbil Alsirhani Alaa 
Published: September 2024

AbstractThis study includes an environmentally and effectively green method for the synthesis of novel 2H‐pyran derivatives 4 a–h via a one‐pot reaction of different aromatic aldehydes 1 a–h with ethyl cyanoacetate (2) and 2‐acetylphenyl‐4‐tolylsulfonate (3) in the presence of nickel oxide nanoparticles (NiO NPs) as a green catalyst in an aqueous mixed solution (EtOH: H2O, 1 : 3 ratio) using microwave irradiation. The structure of all prouducts were confirmed by spectral data and elemental analysis. All compounds were investigated for anti‐inflammatory activity compared with celecoxib as a reference drug. The obtained results indicate that 2‐[4‐(4‐tosyl oxy phenyl)‐3‐cyano‐2‐oxo‐2H‐pyran‐6‐yl]phenyl 4‐tolylsulfonate (4 b) is the most anti‐inflammatory effective, which showed after 5 h., significantly inhibited inflammation compared with the carrageenan alone group (P < 0.0001)., and when compared to the treated group with celecoxib, inflammation was inhibited 42.38 % for compound 4 b compared to celecoxib 48.39 % simultaneously. Moreover, its histopathological examination was studied and showed a significant attenuation of inflammation and edema. The results indicated that pyran derivatives could serve as promising lead compounds for further optimization as anti‐inflammatory agents.The present protocol offers several advantages, such as inexpensive, easy work, pure products, shorter reaction times, excellent yields, environmental friendliness, and easy reuse of the catalyst several times.
Synergistic Effect of Defects Passivation and Energy Level Alignment Realizing P3HT‐Based High‐Efficiency CsPbI3 Perovskite Solar Cells
Authors: Wang Zhongqiang , Yang Gen , Yin Yabo , Li Kangning , Guan Haowei , Yu Xueliang , Xu Bingshe , Yin Shougen , Hao Yuying 
Published: September 2024

AbstractPoly (3‐hexylthiophene) (P3HT) is one of the most efficient hole transport layers (HTLs) in perovskite solar cells (PSCs). However, surface and boundary defects in CsPbI3, and energy level mismatch between CsPbI3 and P3HT lead to a low power conversion efficiency (PCE) in P3HT‐based CsPbI3 PSCs. Here, a synergistic strategy with anti‐solvent (sec‐pentyl alcohol, 2‐PA) and passivators (LiX, X = F, Cl, Br, I) is developed to promote the photovoltaic performance of P3HT‐based CsPbI3 PSCs. It is proved that the 2‐PA washes away the residual DMF and DMAPbI3, and assists the secondary growth of CsPbI3 crystal. LiX not only can passivate iodine (I) vacancies, but also can reduce energy offset at CsPbI3/P3HT interface, accelerating hole extraction process. Finally, an impressive efficiency of 19.26% is obtained due to the synergistic effect of defects passivation and energy alignment, which is 34.4% higher than the 14.32% achieved in Control cell. These findings prove that synergistic strategy of defects passivation and energy alignment is an effective way for realizing high‐efficiency in P3HT‐based CsPbI3 PSCs.
Sustainable Fabrication of Graphene Oxide Cathodes from Graphite of Failed Commercial Li‐Ion Batteries for High‐Performance Aqueous Zn‐Ion Batteries
Authors: Suresh Swapnika , Baji Dona Susan , Santhanagopalan Dhamodaran , Batabyal Sudip K. 
Published: September 2024

AbstractThe need for revamping spent graphite (SG) from battery waste of commercial lithium‐ion batteries and employing it as a source for the synthesis of graphene oxide (GO) is focused. Thus, this work emphasizes the study of GO sheets, synthesized via modified Hummer's method from spent graphite (SG‐GO) as cathodes for an aqueous zinc ion battery (AZIB) system, for the first time in literature. For comparison, graphene oxide is also synthesized using commercial graphite powder, its structural and morphological properties are analyzed with SG‐GO. The coin cell AZIB device is fabricated for both the GOs and the electrochemical performances revealed that SG‐GO portrayed an enhanced charge capacity of 270 mAh g−1 at 0.1 A g−1 in 3 m ZnSO4 in comparison to GO which delivered ≈198 mAh g−1 at the same current density of 0.1 A g−1. The long‐run cycling analysis of SG‐GO elucidated the capacity retention of 77.3% at 1 A g−1 even after 1000 cycles. Moreover, the performance of SG‐GO is inspected in different electrolyte systems and the suitable electrolyte underwent concentration variation studies to figure out the capability of the system in storing Zn2+ ions which is found to be more in 3 M ZnSO4 electrolyte.
Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning
Authors: Bae Seo‐Hyeon , Choi Hosam , Lee Jisun , Kang Min‐Ho , Ahn Seong‐Ho , Lee Yu‐Sun , Choi Huijeong , Jo Sohee , Lee Yeeun , Park Hyo‐Jung , Lee Seonghyun , Yoon Subin , Roh Gahyun , Cho Seongje , Cho Youngran , Ha Dahyeon , Lee Soo‐Yeon , Choi Eun‐Jin , Oh Ayoung , Kim Jungmin , Lee Sowon , Hong Jungmin , Lee Nakyung , Lee Minyoung , Park Jungwon , Jeong Dong‐Hwa , Lee Kiyoun , Nam Jae‐Hwan 
Published: September 2024

AbstractSince the coronavirus pandemic, mRNA vaccines have revolutionized the field of vaccinology. Lipid nanoparticles (LNPs) are proposed to enhance mRNA delivery efficiency; however, their design is suboptimal. Here, a rational method for designing LNPs is explored, focusing on the ionizable lipid composition and structural optimization using machine learning (ML) techniques. A total of 213 LNPs are analyzed using random forest regression models trained with 314 features to predict the mRNA expression efficiency. The models, which predict mRNA expression levels post‐administration of intradermal injection in mice, identify phenol as the dominant substructure affecting mRNA encapsulation and expression. The specific phospholipids used as components of the LNPs, as well as the N/P ratio and mass ratio, are found to affect the efficacy of mRNA delivery. Structural analysis highlights the impact of the carbon chain length on the encapsulation efficiency and LNP stability. This integrated approach offers a framework for designing advanced LNPs and has the potential to unlock the full potential of mRNA therapeutics.
The primitive giant panda Kretzoiarctos beatrix (Carnivora, Ursidae) from the hominid locality of Hammerschmiede: dietary implications
Authors: Kargopoulos Nikolaos , Abella Juan , Daasch Alexander , Kaiser Thomas , Kampouridis Panagiotis , Lechner Thomas , Böhme Madelaine 
Published: September 2024

AbstractExtant giant pandas are among the most herbivorous forms of the order Carnivora, feeding mainly on hard plant material. The first steps of their evolutionary lineage are of particular interest for our understanding of the factors that led to this specialized niche. The present work deals with newly discovered dental material of the primitive ailuropodine bear Kretzoiarctos beatrix from the Late Miocene locality of Hammerschmiede (Germany). This is the first report of the genus Kretzoiarctos outside the Iberian Peninsula, expanding its spatial range to Central Europe. All of the currently known localities with K. beatrix, from both Spain and Germany, are very similar in age (c. 11.9–11.4 Ma). The present material has distinct features that enable its taxonomic discrimination from other Miocene ursids of Europe, such as Ballusia, Ursavus, Miomaci, Agriarctos and Indarctos. A thorough comparison is conducted of all of these forms. The new specimens were used in a dental microwear texture analysis in combination with ecomorphological comparisons, to investigate the dietary habits of this primitive ailuropodine. The results suggest that Kretzoiarctos was not an eater of tough plant material like the extant giant panda but was more similar to the extant Tremarctos, exhibiting opportunistic behaviour with occasional consumption of meat.