bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parasitic Infection byPseudocapillaria tomentosais Associated with a Longitudinal Restructuring of the Zebrafish Gut Microbiome
Authors: Gaulke Christopher A. , Martins Mauricio L , Watral Virginia , Kent Michael L. , Sharpton Thomas J. 
Published: September 2016

AbstractHelminth parasites represent a significant threat to wild, domesticated, and research animal health.Pseudocapillaria tomentosais a common intestinal nematode parasite and an important source of infection in zebrafish. Symptoms of the infection vary widely from no clinical signs to sever emaciation and mortality, however, the reasons underpinning these disparate outcomes are unclear. Components of the microbiome may interact with parasites to influence their success in the gut while parasite infections are also known to influence the composition of the gut microbiome. In this study we evaluated the longitudinal changes in the gut microbiome structure and gut physiology during experimentalP. tomentosainfection in adult 5D line zebrafish. We observed less severe signs of infection and less mortality in these fish than previously described in AB line fish. However, inflammation and epithelial hyperplasia in the intestine was still observed in infected 5D line fish. The composition of the microbiome changed rapidly during the infection and these changes were associated with parasite stage of development and burden. Individual taxa covaried with parasite abundance in the intestine intimating the gut microbiome may influence parasite burden. Associations between taxa and parasite abundance in some cases appeared to be phylogenetically patterned. Strong positive associations were observed between OTUs phylotyped to Proteobacteria and abundance of adult parasites and parasite eggs. Together these experiments demonstrate thatP. tomentosainfection results in a rapid and temporally dynamic disruption of the zebrafish gut microbiome and clarify how interactions between the gut microbiome and intestinal parasites may impact fish populations.
Data Aggregation at the Level of Molecular Pathways Improves Stability of Experimental Transcriptomic and Proteomic Data
Authors: Borisov Nicolas , Suntsova Maria , Garazha Andrew , Lezhnina Ksenia , Kovalchuk Olga , Aliper Alexander , Ilnitskaya Elena , Sorokin Maxim , Korzinkin Mihkail , Saenko Vyacheslav , Saenko Yury , Sokov Dmitry G. , Gaifullin Nurshat M. , Kashintsev Kirill , Shirokorad Valery , Shabalina Irina , Zhavoronkov Alex , Mishra Bhubaneswar , Cantor Charles R. , Buzdin Anton 
Published: September 2016

ABSTRACTHigh throughput technologies opened a new era in biomedicine by enabling massive analysis of gene expression at both RNA and protein levels. Unfortunately, expression data obtained in different experiments are often poorly compatible, even for the same biological samples. Here, using experimental and bioinformatic investigation of major experimental platforms, we show that aggregation of gene expression data at the level of molecular pathways helps to diminish cross- and intra-platform bias otherwise clearly seen at the level of individual genes. We created a mathematical model of cumulative suppression of data variation that predicts the ideal parameters and the optimal size of a molecular pathway. We compared the abilities to aggregate experimental molecular data for the five alternative methods, also evaluated by their capacity to retain meaningful features of biological samples. The bioinformatic method OncoFinder showed optimal performance in both tests and should be very useful for future cross-platform data analyses.
PDGF signaling directs cardiomyocyte movement toward the midline during heart tube assembly
Authors: Bloomekatz Joshua , Singh Reena , Prall Owen W.J. , Dunn Ariel C. , Vaughan Megan , Loo Chin-San , Harvey Richard P. , Yelon Deborah 
Published: September 2016

AbstractCommunication between neighboring tissues plays a central role in guiding organ morphogenesis. During heart tube assembly, interactions with the adjacent endoderm control the medial movement of cardiomyocytes, a process referred to as cardiac fusion. However, the molecular underpinnings of this endodermal-myocardial relationship remain unclear. Here, we show an essential role for platelet-derived growth factor receptor alpha (Pdgfra) in directing cardiac fusion. In both zebrafish and mouse, mutation ofpdgfrainhibits cardiac fusion and can lead to cardia bifida. Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafishpdgframutants, suggesting that PDGF signaling steers cardiomyocytes toward the midline. Intriguingly, the ligandpdgfaais expressed in the endoderm medial to thepdgfra-expressing myocardial precursors. Ectopic expression ofpdgfaainterferes with cardiac fusion, consistent with an instructive role for PDGF signaling. Together, these data uncover a novel mechanism through which endodermal-myocardial communication guides the cell movements that initiate cardiac morphogenesis.IMPACT STATEMENTStudies in zebrafish and mouse implicate the PDGF signaling pathway in the communication between the endoderm and the myocardium that drives medial myocardial movement and thereby initiates cardiac morphogenesis.
Layout validation and re-configuration in Plug&Produce systems
Authors: Neves Pedro , Ribeiro Luis , Dias-Ferreira João , Onori Mauro , Barata Oliveira José 
Published: September 2016

Purpose
This paper aims to provide a method and decision support tool to enhance swift reconfiguration of Plug&Produce (P&P) systems in the presence of continuously changing production orders.

Design/methodology/approach
The paper reviews different production scenarios and system design and configuration methods and more particularly specifies the need of decision support tools for P&P systems that integrate configuration and planning activities. This problem is then addressed by proposing a method that helps reduce the solution space of the reconfiguration problem and allows the timely selection of the most promising reconfiguration alternative.

Findings
The proposed method was found to be helpful in reducing the reconfiguration alternatives that need to be considered and in selecting the most promising one for different orders. The advantages and limitations of this method are identified, and an illustrative test case of the approach is presented, corroborating the method applicability in the absence of large queues in the system.

Originality/value
This paper addresses a less explored domain within the P&P systems research field, which is the system reconfiguration. It proposed a method to support system validation and reconfiguration jointly with an illustrative test case. This represents an original contribution to the P&P research field, and it can have impact in improving agility and decreasing the complexity of reconfiguration activities to cope with constantly changing production orders.
An automated assembly technology for large mobile radar antenna
Authors: Peng Gaoliang , Sun Yu , Han Rui , Li Chuanhao 
Published: September 2016

Purpose
Large-scale mobile radars are still erected manually by using lifting equipment, which often fails to meet the requirements on precision, quality and efficiency in the erecting process. This paper aims to introduce techniques for automatic assembly of large mobile radar antenna.

Design/methodology/approach
A large-scale metrology system for accurate identification of the positions and orientation of the radar antenna components is presented. A novel three-degree-of-freedom parallel mechanism is designed to realize orientation adjustment of three axes synchronous, and, thus guarantees the efficiency and accuracy of positioning process.

Findings
The system described in this paper is practicable in outdoor environment and provides a holistic solution that gives full consideration of the operation conditions and the environmental influences. In performance evaluation tests, the measured absolute accuracy is less than ±1 mm and repeatability is less than ±0.5 mm in the positioning task for 10 × 3 m large antenna.

Originality/value
This paper presents a new concept of an automatic assembly technology for the large radar antenna application.
Method of estimation of corrosion stability of multicomponent alloys using equilibrium and polarization potential – pH diagrams
Authors: Tyurin Aleksandr Georgievich , Manannikov Dmitriy Andreevich , Parshukov Vladimir Pavlovich , Antonova Anna Valeryevna , Nikolaychuk Pavel Anatolyevich 
Published: September 2016

Purpose
The purpose of this study is to develop a method of thermodynamic and kinetic evaluation of corrosion properties of alloys.

Design/methodology/approach
Method of estimation of corrosion-electrochemical behaviour of multicomponent alloys is proposed. The method takes into account both thermodynamic and kinetic data and is based on mutual construction of equilibrium and polarization potential – pH diagrams. The usage of the proposed method is illustrated in the example of the structural steel 20KT.

Findings
Passivation of steel 20KT is determined by formation of oxide film based on magnetite (Fe3O4); silicon, manganese and copper oxides as well as manganese sulphides can be locally included into the inner side of the passivation layer. An experimental potential – pH diagram of steel 20KT is constructed. Interpreting the results of polarization measurements revealed good agreement between equilibrium and polarization potential – pH diagrams.

Originality/value
It is shown in the example of structural steel 20KT that for interpretation of experimental potential – pH diagrams, one should compare them with corresponding equilibrium diagrams for multicomponent alloys rather than with Pourbaix diagrams for pure metals. The corrosion properties of steel 20KT are estimated using equilibrium and polarization potential – pH diagrams.
Averting risk or embracing opportunity? Exploring the impact of ambidextrous capabilities on innovation of Chinese firms in internationalization
Authors: Zhou Yu , Lu Lu , Chang Xiaoxi 
Published: September 2016

PurposeThe purpose of this paper is to examine the impacts of ambidextrous capabilities, explorative capability and exploitative capability on product innovation performance in the context of internationalization and cross-cultural environment; and to examine the moderating effects of CEO’s preference of risks and opportunities in the international market on the relationship between ambidextrous capabilities and multinational enterprises’ (MNEs) product innovation performance.Design/methodology/approachData were collected from 189 MNEs located in China, which develop international business through export, outsourcing, foreign equity investment or foreign direct investment. Measurement reliability and validity were examined and hierarchical linear regression was used to test the hypotheses.FindingsResults indicated that both explorative and exploitative capability are positively related to MNEs’ new product development and commercialization of Chinese MNEs; and CEO’s preference of risks and opportunities in international market plays a significant moderating role in the two phases of product innovation.Research limitations/implicationsThis study extends organizational ambidextrous capabilities theory to better understand the effects of explorative capability and exploitative capability on innovation performance in the context of internationalization and national cultural differences. Sample constitution is a possible limitation.Practical implicationsMNEs, especially those from emerging economies, should develop both explorative and exploitative capability to be flexible and competitive in dealing with cultural differences. fully take risks and opportunities should be taken into consideration regarding the international market and national cultural differences, and take an effective contingency strategy, driven by the ambidextrous capabilities toward new product innovation development and commercialization.Originality/valueAn empirical examination of how ambidextrous capabilities impact on Chinese MNEs’ new product development and commercialization connects the organizational ambidexterity theory to the innovation and characteristics of upper echelons.
Managing digital records in a global environment
Authors: Katuu Shadrack 
Published: September 2016

Purpose
This paper aims to widen as well as deepen the discussion on standards and good practice guidelines beyond just local or regional efforts and include international developments.

Design/methodology/approach
An extensive review of literature was used to develop an outline of existing standards and good practice guidelines that are used by records management professionals to manage digital records.

Findings
The analysis reveals that there has been a long tradition in standards and good practice guidelines development dating back to the 1980s. The study also reveals that there are two broad categories of standards and good practice guidelines, those with assessment mechanisms and those without such mechanisms. The choice of whether to have an assessment mechanism depends on the purpose for which a standard or good practice guideline is developed.

Originality/value
The paper explores an extensive array of standards and good practice guidelines, their utility and their geographical coverage. It demonstrates how different terms such as Electronic Records Management Systems, Electronic Document Management Systems, Electronic Document and Records Management Systems and Enterprise Content Management have been used without much clarity on how these terms relate to each other, and proposes a clarification framework.
The status of open access library and information science journals in SSCI
Authors: Chen Ming , Du Yunfei 
Published: September 2016

Purpose
The main purpose of this paper is to measure the status and quality of library and information science (LIS) open-access (OA) journals in the Social Science Citation Index (SSCI).

Design/methodology/approach
The study selected 86 source journals of LIS in the SSCI as a sample and measured their status of open access. Analytic hierarchy process (AHP) was used to analyze 36 OA journals of 86 source journals, especially their production capability, academic influence and network communication ability.

Findings
The results indicate that OA journals have become an increasingly important part of LIS journals. Production capability, academic influence and network communication ability are important factors affecting the quality of OA journals. These three evaluation indicators of LIS OA journals are high, but many still have room for improvement.

Research limitations/implications
As the paper is limited by collecting data, the indicators of OA journals’ quality are not all-around. So, they cannot reflect the quality of LIS OA journals. In the selection of the evaluation method, the evaluation results are limited because only one AHP method is used.

Practical implications
The research on evaluation of OA journals can help library and scientific research personnel use OA journals effectively. Identifying key factors on evaluation can help researchers to construct OA journals better.

Social implications
The research on OA journals’ quality can also promote the study on OA process in academic circles and promote the communication, development and utilization of academic information. Such research can also enrich the theory of OA, and provide some new perspectives for the study of journals’ evaluation.

Originality/value
This paper measures the quality of LIS OA journals by analyzing production capability, academic influence and network communication ability. Rather than the traditional research methods, the focus of this study is on the value of the Web as a source of impact indices. It contributes to the scholarly impact measurements of OA journals.
I feel like a hypocrite: a beginning teacher’s disconnect between beliefs and practice
Authors: Knotts Michelle 
Published: September 2016

Purpose
This study aims to examine the lived experiences of a beginning teacher to understand the constraints and possibilities she faces in moving from a critically minded preservice teacher toward a critical educator during her first year of teaching secondary English Language Arts at a public high school in the Southwestern USA.

Design/methodology/approach
This research was conducted as a qualitative case study. The data set was collected through interviews, documents and observations. Data were analyzed inductively using open coding techniques and grounded theory in order to establish themes.

Findings
The research describes three themes: losing a sense of self, losing hope and losing sight. These themes explore in order to illustrate the participant’s sense of loss, the disconnect between her stated beliefs and practice and how contextual factors contribute to her experiences.

Practical implications
The paper includes recommendations for teacher induction and undergraduate initial teacher education.

Originality/value
This research contributes to the literature about beginning teachers and their challenges to realize their stated beliefs in practice. It extends this body of literature with a specific focus on criticality and an exploration of how the current corporate reform paradigm impacts beginning teachers and how these topics can be taken up in teacher education.
Grab those teachable moments! (On teacher identities and student learning)
Authors: Keranova Hristina 
Published: September 2016

Purpose
This study aims to use the works of Bakhtin and theorists who further developed his ideas to show the struggle teachers go through in trying to balance different identities in the classroom and the effect of that process on student learning.

Design/methodology/approach
The author-transcribed observations and interviews are analyzed using ATLAS.ti qualitative research software, and narrative vignettes are used for data representation.

Findings
It gives a glimpse of the difficulty in making choices when professional identities, based on established criteria for professionalism and determining self-esteem, are at stake. The two vignettes used to represent the data blend the informative with the evocative and dramatize the readers’ perception by giving voice to the participants.

Originality/value
The study illustrates the importance of adapting fossilized teacher identities to the specificity of each classroom to support student learning.
Variable portfolio proposal for banking efficiency assessment
Authors: Macoris Lucas Serrao , Salgado Jr Alexandre Pereira , Branco Adriel Martins de Freitas , Ciribelli Fábio Neves 
Published: September 2016

Purpose
The importance of banking efficiency has been shown to have become increasingly relevant, not only for researchers but also for decision makers. However, the large number of combinations between the variables used and the different approaches considered to measure efficiency caused a divergence between authors regarding the inputs and outputs used. The paper aims to discuss these issues.

Design/methodology/approach
On the basis of a critical analysis of the main variables used in literature, this paper proposes a set of inputs and outputs to be used with consideration of the main approaches to banking efficiency.

Findings
Filling a gap in the literature, this study contributes to the development of future studies by suggesting variables which, in accordance with the theory related to banking efficiency, are highly suitable for creating relevant information for decision-making.

Originality/value
Frontier techniques are largely applied for assessing efficiency not only in large financial institutions, but also in bank branches and other regional units. Although a wide variation of articles follows a set of inputs and outputs without arguing for its suitability, this paper differs from the vast majority of applications by discussing the most reliable set of variables to represent efficiency levels.
Food security in Cambodia: trends and policy objectives
Authors: Culas Richard J. , Tek Kimsong 
Published: September 2016

Purpose
The paper presents food and nutritional status and relevant policy objectives that can sustain food security in Cambodia. This paper aims to review Cambodia’s food security situation over a period.

Design/methodology/approach
The paper provides an approach for selecting food security indicators in relation to both inputs and outcomes by drawing on a conceptual framework. National level data for the food security indicators are analysed over a period to provide trends in food and nutritional status.

Findings
Cambodia has not experienced drastic food insecurity yet, as most people are farmers and their livelihoods dependent on agriculture. Agriculture has maintained food availability in the country; however, there is a proportion of the population living in remote areas unable to obtain sufficient, safe, nutritious food. Landlessness, internal migration, rapid population growth, lack of education and skills, limited access to natural resources and agricultural land, poor health and infrastructure leave the people with inadequate employment opportunities, low capabilities and low productivity which in turn bring deeper poverty. Therefore, people are insecure, excluded and vulnerable to food deprivation.

Practical implications
To tackle the food security challenges, the Government of Cambodia focuses on food-based social safety nets in the sectors of education, nutrition and productive assets/livelihoods support, to enable longer-term, nationally owned food security solutions.

Originality/value
The paper draws conclusions using a range of recently proposed food security indicators and offers a perspective for policy formulation which may be of interest to development scholars and practitioners.
Framework for measuring performance of the sales and operations planning process
Authors: Hulthén Hana , Näslund Dag , Norrman Andreas 
Published: September 2016

Purpose
The purpose of this paper is to develop a framework for measuring the S&OP process performance.

Design/methodology/approach
The method used is a multiple case study of five companies from different industries based on data from 12 structured interviews.

Findings
The main result is a framework to measure the S&OP process. It includes concrete suggestions for organizations when developing measures to increase effectiveness and efficiency of the process. It will also help organizations to standardize measures and to enhance organizational transparency. Our results include measures for every step of the process as well as for the outcome of the process. The authors highlight the importance of cross-functional measures along with measures that focus on how to conduct the process. The framework is founded on a set of criteria on appropriate measures such as comprehensiveness, internal process efficiency, horizontal and vertical integration, internal comparability, and usefulness. The study contributes to performance measurement literature and the S&OP literature.

Research limitations/ implications
Validation of the framework is desirable in similar as well as other contexts. Implementation challenges should also be investigated.

Practical implications
The framework provides guidelines in order to measure, analyze and improve the effectiveness and the efficiency of the process.

Originality/values
This is the first framework for measuring the S&OP process that includes detailed measures for each step of the process, for the outcome of the process as well as how to conduct the process itself.