bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of universal and cell type specific p53 DNA binding
Authors: Hafner Antonina , Kublo Lyubov , Lahav Galit , Stewart-Ornstein Jacob 
Published: August 2017

AbstractThe tumor suppressor p53 is a major regulator of the DNA damage response and has been suggested to selectively bind and activate cell type specific gene expression programs, however recent studies and meta-analyses of genomic data propose largely uniform, and condition independent, p53 binding. To systematically assess the cell type specificity of p53, we measured its association with DNA in 12 p53 wild-type cell lines, from a range of epithelial linages, in response to ionizing radiation. We found that the majority of bound sites were occupied across all cell lines, however we also identified a subset of binding sites that were specific to one or a few cell lines. Unlike the shared p53-bound genome, which was not dependent on chromatin accessibility, the association of p53 with these atypical binding sites was well explained by chromatin accessibility and could be modulated by forcing cell state changes such as the epithelial-to-mesenchymal transition. These results position p53 as having both universal and cell type specific regulatory programs that have different regulators and dependence on chromatin state.
Effects of species invasion on population dynamics, vital rates, and life histories of the native species
Authors: Vincenzi Simone , Crivelli Alain J , Jesensek Dusan , Campbell Ellen , Garza John C 
Published: August 2017

AbstractInvasions occurring in natural environments provide the opportunity to study how vital rates change and life histories evolve in the presence of a competing species. In this work, we estimate differences in reproductive traits, individual growth trajectories, survival, life histories, and population dynamics between a native species living in allopatry and in sympatry with an invasive species of the same taxonomic Family. We used as a model system marble troutSalmo marmoratus(native species) and rainbow troutOncorhynchus mykiss(non-native) living in the Idrijca River (Slovenia). An impassable waterfall separates the stream in two sectors only a few hundred meters apart: a downstream sector in which marble trout live in sympatry with rainbow trout and a upstream sector in which marble trout live in allopatry. We used an overarching modeling approach that uses tag-recapture and genetic data (> 2,500 unique marble and rainbow trout were sampled and SNP-genotyped) to reconstruct pedigrees, test for synchrony of population dynamics, and model survival and growth while accounting for individual heterogeneity in performance. The population dynamics of the two marble trout populations and of rainbow trout were overall synchronous. We found higher prevalence of younger parents, higher mortality, and lower population density in marble trout living in sympatry with rainbow trout than in marble trout living in allopatry. There were no differences in the average individual growth trajectories between the two marble trout populations. Faster life histories of marble trout living in sympatry with rainbow trout are consistent with predictions of life-history theory.
Case report: intermittent fasting and probiotic yogurt consumption are associated with reduction of serum alpha-N-acetylgalactosaminidase and increased urinary excretion of lipophilic toxicants
Authors: Blythe Jerry , Ruggiero Marco , Pacini Stefania 
Published: August 2017

AbstractIn this study, we describe the changes associated with three months of intermittent fasting and probiotic yogurt consumption in a 72-year-old marathon runner with chronic lymphocytic leukemia for a number of years. Serum alpha-N-acetylgalactosaminidase (nagalase), a marker of inflammation and cancer cell proliferation, was significantly decreased at the end of a three-month observation. These results are consistent with immune modulating properties of certain probiotics based on the fermentation of milk and colostrum. Urinary excretion of non-metal toxicants that accumulate in adipose tissue such as Perchlorate, N-acetyl(2-hydroxypropyl)cysteine (NAHP), 2,4-Dichlorophenoxyacetic acid, 3-Phenoxybenzoic acid (3PBA), N-acetyl phenyl cysteine (NAP), Phenylglycoxylic acid (PGO), Monoethylphthalate (MEP) and 2-Hydroxyisobutyric Acid (2HIB) was significantly increased. These results are consistent with the weight loss (5 Kg) associated with intermittent fasting and with the known features of probiotics as detoxification tools. Consistent with certain toxicants acting as endocrine disruptors, we observed an increased elimination of toxicants and a 33% decrease of serum Thyroid Stimulating Hormone (TSH), suggesting a trend toward normalization of thyroid function. These results support the hypothesis that a combination of intermittent fasting with the consumption of specific probiotic yogurts may lead to immune modulation, detoxification and other improvements.Abbreviations(NAHP)N-acetyl(2-hydroxypropyl)cysteine(3PBA)3-Phenoxybenzoic acid(NAP)Nacetyl phenyl cysteine(PGO)Phenylglycoxylic acid(MEP)Monoethylphthalate(2HIB)2-Hydroxyisobutyric Acid(TSH)Thyroid Stimulating Hormone(Dr. JB)Dr. Jerry Blythe(CLL)chronic lymphocytic leukemia(IRB)Institutional Review Board(GcMAF)Gc protein-derived Macrophage Activating Factor
The evolution of nesting behaviour inPeromyscusmice
Authors: Lewarch Caitlin L. , Hoekstra Hopi E. 
Published: August 2017

ABSTRACTStructures built by animals, such as nests, often can be considered extended phenotypes that facilitate the study of animal behaviour. For rodents, nest building is both an important form of behavioural thermoregulation and a critical component of parental care. Changes in nest structure or the prioritization of nesting behaviour are therefore likely to have consequences for survival and reproduction, and both biotic and abiotic environmental factors are likely to influence the adaptive value of such differences. Here we first develop a novel assay to investigate interspecific variation in the nesting behaviour of deer mice (genusPeromyscus). Using this assay, we find that, while there is some variation in the complexity of the nests built byPeromyscusmice, differences in the latency to begin nest construction are more striking. Four of the seven taxa examined here build nests within an hour of being given nesting material, but this latency to nest is not related to ultimate differences in nest structure, suggesting that the ability to nest is relatively conserved within the genus, but species differ in their prioritization of nesting behaviour. We also find that latency to nest is not correlated with body size, climate, or the construction of burrows that create microclimates. However, the four taxa with short nesting latencies all have monogamous mating systems, suggesting that differences in nesting latency may be related to social environment. This detailed characterization of nesting behaviour within the genus provides an important foundation for future studies of the genetic and neurobiological mechanisms that contribute to the evolution of behaviour.
Making visible the invisible through the analysis of acknowledgements in the humanities
Authors: A. Díaz-Faes Adrian , Bordons María 
Published: August 2017

PurposeScience is subject to a normative structure that includes how the contributions and interactions between scientists are rewarded. Authorship and citations have been the key elements within the reward system of science, whereas acknowledgements, despite being a well-established element in scholarly communication, have not received the same attention. The purpose of this paper is to put forward the bearing of acknowledgements in the humanities to bring to the foreground contributions and interactions that, otherwise, would remain invisible through traditional indicators of research performance.Design/methodology/approachThe study provides a comprehensive framework to understanding acknowledgements as part of the reward system with a special focus on their value in the humanities as a reflection of intellectual indebtedness. The distinctive features of research in the humanities are outlined and the role of acknowledgements as a source of contributorship information is reviewed to support these assumptions.Findings“Peer interactive communication” is the prevailing support thanked in the acknowledgements of humanities, so the notion of acknowledgements as “super-citations” can make special sense in this area. Since single-authored papers still predominate as publishing pattern in this domain, the study of acknowledgements might help to understand social interactions and intellectual influences that lie behind a piece of research and are not visible through authorship.Originality/valuePrevious works have proposed and explored the prevailing acknowledgement types by domain. This paper focusses on the humanities to show the role of acknowledgements within the reward system and highlight publication patterns and inherent research features which make acknowledgements particularly interesting in the area as a reflection of the socio-cognitive structure of research.
Why do you publish? On the tensions between generating scientific knowledge and publication pressure
Authors: Hangel Nora , Schmidt-Pfister Diana 
Published: August 2017

Purpose
The purpose of this paper is to examine researchers’ motivations to publish by comparing different career stages (PhD students; temporarily employed postdocs/new professors; scholars with permanent employment) with regard to epistemic, pragmatic, and personal motives.

Design/methodology/approach
This qualitative analysis is mainly based on semi-structured narrative interviews with 91 researchers in the humanities, social, and natural sciences, based at six renowned (anonymous) universities in Germany, the UK, and the USA. These narratives contain answers to the direct question “why do you publish?” as well as remarks on motivations to publish in relation to other questions and themes. The interdisciplinary interpretation is based on both sociological science studies and philosophy of science in practice.

Findings
At each career stage, epistemic, pragmatic, and personal motivations to publish are weighed differently. Confirming earlier studies, the authors find that PhD students and postdoctoral researchers in temporary positions mainly feel pressured to publish for career-related reasons. However, across status groups, researchers also want to publish in order to support collective knowledge generation.

Research limitations/implications
The sample of interviewees may be biased toward those interested in reflecting on their day-to-day work.

Social implications
Continuous and collective reflection is imperative for preventing uncritical internalization of pragmatic reasons to publish. Creating occasions for reflection is a task not only of researchers themselves, but also of administrators, funders, and other stakeholders.

Originality/value
Most studies have illuminated how researchers publish while adapting to or growing into the contemporary publish-or-perish culture. This paper addresses the rarely asked question why researchers publish at all.
Foreign subsidiaries’ competitive strategy: the impact of corporate support and local competition
Authors: Pehrsson Anders 
Published: August 2017

PurposeThe study draws on the resource-based view and the contingency view of strategy. The purpose of this paper is to contribute to international strategy literature by extending the current understanding of foreign subsidiary’s competitive strategy in terms of cost leadership and product differentiation.Design/methodology/approachHypotheses concern associations between corporate support building on product and skills relatedness and subsidiary strategies. Also, it is hypothesized that strategies are due to the type of local competitive intensity. The hypotheses were tested on wholly owned subsidiaries of Swedish industrial firms in Germany, the UK and the USA.FindingsProduct and skills relatedness between the subsidiary and the corporate core unit are positively associated with the subsidiary’s emphasis on cost leadership. Also, a positive association was found between skills relatedness and product differentiation, and extensive competitive intensity strengthens the relationship.Research limitations/implicationsThe study specifies what business relatedness is needed for a subsidiary’s competitive strategy; skills relatedness is more important than product relatedness; the type of local competitive intensity is important; corporate support and local strategy operate simultaneously.Practical implicationsManagement is advised to implement a foreign subsidiary’s competitive strategy by recognizing the mechanisms identified in this study.Originality/valueIn a unique way, the study captures the role of corporate support of a foreign subsidiary’s competitive strategy relying on business relatedness and the importance of aligning the strategy with competitive intensity.
Passive innovation resistance – a conservative consumer perspective
Authors: Van Tonder Estelle 
Published: August 2017

Purpose
More research is required into the underlying reasons for passive innovation resistance. This paper aims to propose that consumers who passively resist innovation may merely be conservative in nature and explore a conceptual framework that could explain and predict such behaviour.

Design/methodology/approach
Theories from the political sciences, social psychology and marketing were studied in trying to understand why some consumers are more conservative in nature and how their attitudes may affect their thoughts, feelings and actions in the marketplace.

Findings
Consumers may develop conservative attitudes, such as a need for cognitive closure, nostalgia, authoritarianism, a social dominance orientation, ethnocentrism and an anti-hedonic approach towards life to combat their fear of ambiguous situations and chaos associated with deviance from in-group values. Ultimately, these attitudes may influence consumer behaviour, such as being brand loyal, unwilling to try new options and preferring nostalgic products that would lead to lower levels of ambiguity and less disruption of the status quo. Conservative consumers may also act as authoritarian parents, prefer to purchase durable materialistic products, support locally manufactured goods and refrain from purchasing products for purely hedonic pleasure in an attempt to preserve their in-group values.

Originality/value
The proposed framework offers more insight into the nature and consequences of passive innovation resistance and may serve as a starting point for further exploration on the fundamental characteristics of conservative consumers. The research findings may also assist marketers in managing their new product innovations strategies more successfully.
The innovation capacity of small food firms in Italy
Authors: De Martino Marcella , Magnotti Fabio 
Published: August 2017

Purpose
The purpose of this paper is to analyze the innovation capacity of small and medium enterprises (SMEs) and micro enterprises through a theoretical framework that addresses the influence of some internal and external resources – derived from the literature review – on the development of innovation activities and on innovative firm’s results.

Design/methodology/approach
Based on a structured questionnaire, the empirical survey has involved 122 SMEs and micro enterprises of the most representative agrifood supply chains in the Campania region: dairy, wine, pasta and olive oil. The data have been then elaborated through the cluster analysis technique in order to explore any meaningful patterns that may exist in terms of the innovation capacity.

Findings
This study shows the existence of three clusters/innovation modes: collaborative innovators (CIs), non-collaborative innovators (NCIs), and non-innovators (NIs). Even though CIs represent 16.2 percent of the sample, this cluster shows an increased or stable revenue during 2011-2013 in comparison to the other two clusters.

Research limitations/implications
This study provides a static view in comparison to the longitudinal analysis which could have provided a more dynamic view of the innovation capacity of agrifood SMEs and micro enterprises.

Originality/value
This is the first quantitative study focusing on the factors related to the innovation capacity of agrifood firms in the Campania Region. The study specifically analyses the innovation capacity of SMEs and micro enterprises. Moreover, it offers a comprehensive analysis of internal and external drivers to innovation.
The influence of government support and awareness on rural farmers’ intention to adopt mobile government services in Tanzania
Authors: Mandari Herman Eliewaha , Chong Yee-Lee , Wye Chung-Khain 
Published: August 2017

Purpose
Generally, this paper aims to develop a model by identifying factors which will assist policy makers in implementing m-government in Tanzania. The paper identifies direct and indirect factors which may influence adoption of m-government among the rural farmers in Tanzania.

Design/methodology/approach
The paper conducted a survey by using Drop Off/Pick Up method to collect data from rural farmers. Stratified and multi-stage sampling were used to collect 407 valid responses from rural farmers in Tanzania. Data collected were analyzed by using structural equation modeling (SEM).

Findings
The results show that government support has direct influence, while awareness has indirect influence through relative advantage, ease of use, compatibility and visibility. Furthermore, relative advantage, compatibility, ease of use, visibility and results demonstrability have direct influence on rural farmers intention to adopt m-government.

Originality/value
This study contributes to knowledge because no study in this area has been conducted in developing countries to examine factors that influence adoption of m-government. Furthermore, this study tests the mediating effects of perceived characteristics of innovation which have not yet been investigated to date.
Asset management the track towards quality documentation
Authors: Tyler Jacqueline Edana 
Published: August 2017

Purpose
The purpose of this paper is to share the experience of the document discovery process, during the implementation of an asset management system for a rail company. This system will deliver comprehensive enterprise asset management information from a single source, with information provided to mobile devices, for use by field workers. This case study presents the challenges encountered in the search, retrieval and management of documentation for use on a daily basis for civil standard maintenance tasks.

Design/methodology/approach
Evidence gathered for this paper was a result of direct and participant observation over a period of 18 months from 2014 to 2016. As a member of the project team, certain privileges were accorded to the researcher who was placed in a unique position to act as the main research instrument, able to collect data on the systems used as well as the everyday practices on information capture and document production.

Findings
Document quality and standards can be overlooked or deemed as not crucial; the value, significance and importance of documentation are lost when no one takes ownership; the understanding and application of standards, quality management and governance can have a direct bearing on the effective management and control of documents and subsequent records produced.

Research limitations/implications
Research is limited, as this is a single case study.

Practical implications
By highlighting the challenges faced and the resolutions used, this paper hopes to offer a level of practical guidance with the detection process for maintenance tasks for the civil assets discipline for a rail network.

Originality/value
This case study contributes to the understanding of quality management and the role it plays in document management and in turn the search and retrieval process. It provides evidence that documents must be systematically managed and controlled to limit risk both internally and externally.
Investigating the interlinkages between infrastructure development, poverty and rural–urban income inequality
Authors: Chotia Varun , Rao N.V.M. 
Published: August 2017

Purpose
The purpose of this paper is to investigate the relationship between infrastructure development, rural–urban income inequality and poverty for BRICS economies.

Design/methodology/approach
Pedroni’s panel co-integration test and panel dynamic ordinary least squares (PDOLS) have been used to carry out the analysis.

Findings
The empirical findings confirm a long-run relationship among infrastructure development, poverty and rural–urban inequality. The PDOLS results suggest that both infrastructure development and economic growth lead to poverty reduction in BRICS. However, rural–urban income inequality aggravates poverty in these nations. The paper advocates for adopting policies aimed at strengthening infrastructure and achieving economic growth to reduce the current levels of poverty prevailing in the BRICS nations.

Originality/value
Significant limitations exist in the literature in terms of not clearly defining the nature of relationship and interlinkages between infrastructure development, poverty and inequality, with regard to the BRICS nations. The available studies mainly focus on the relationship between infrastructure and growth, with the universal agreement being that these two are positively related. However, it is still not right to assume that economic growth attributable to infrastructure development will, therefore, subsequently lead to a reduction in inequality. This forms the basis for this study, that is, to critically examine the relationship between infrastructure development, inequality and poverty for BRICS nations.
Global financial crisis, ownership structure and firm financial performance
Authors: Saleh Ali Salman , Halili Enver , Zeitun Rami , Salim Ruhul 
Published: August 2017

Purpose
This paper aims to investigate the financial performance of listed firms on the Australian Securities Exchange (ASX) over two sample periods (1998-2007 and 2008-2010) before and during the global financial crisis periods.

Design/methodology/approach
The generalized method of moments (GMM) has been used to examine the relationship between family ownership and a firm’s performance during the financial crisis period, reflecting on the higher risk exposure associated with capital markets.

Findings
Applying firm-based measures of financial performance (ROA and ROE), the empirical results show that family firms with ownership concentration performed better than nonfamily firms with dispersed ownership structures. The results also show that ownership concentration has a positive and significant impact on family- and nonfamily-owned firms during the crisis period. In addition, financial leverage had a positive and significant effect on the performance of Australian family-owned firms during both periods. However, if the impact of the crisis by sector is taking into account, the financial leverage only becomes significant for the nonmining family firms during the pre-crisis period. The results also reveal that family businesses are risk-averse business organizations. These findings are consistent with the underlying economic theories.

Originality/value
This paper contributes to the debate whether the ownership structure affects firms’ financial performance such as ROE and ROA during the global financial crisis by investigating family and nonfamily firms listed on the Australian capital market. It also identifies several influential drivers of financial performance in both normal and crisis periods. Given the paucity of studies in the area of family business, the empirical results of this research provide useful information for researchers, practitioners and investors, who are operating in capital markets for family and nonfamily businesses.