bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing a broad-spectrum multi-epitope mRNA candidate vaccine targeting the Porcine Pseudorabies Virus (PRV) gB protein based on immunoinformatics-guided approaches
Authors: Gan Tianyirui , Pan Zhicheng , Xu Yezhao , Yi Haibo , Zhu Xuerui , Zhou Yuancheng , Xiong Yongai , Gao Xinghong 
Published: September 2024

Abstract

Pseudorabies virus (PRV) is an alpha-herpesvirus capable of infecting pigs, resulting in reproductive disorders in sows, orchitis in boars, piglet diarrhea, and various other diseases, thus inflicting significant economic losses on the swine industry. The advancement of immunoinformatic and computer epitope prediction technologies holds promise in designing optimal candidate vaccines. Therefore, in this study, based on the non-conserved properties of PRV gB proteins and adsorption acting on viruses, we used immunoinformatics tools to design a multi-epitope mRNA vaccine for gB proteins of the three PRV vaccine strains (types I and II) containing five CTL, two HTL, and five LBL shared epitopes, which was named the MgB vaccine in this study. Subsequent steps involved the prediction, optimization, and evaluation of the vaccine's structure and physicochemical properties to closely mimic the natural state. Concurrently, the immunization effect of the vaccine is evaluated by simulating the reaction process of the vaccine with the receptor in vivo and the immune response of the vaccine. The immunoinformatic analysis revealed promising immunological activity of the multi-epitope mRNA vaccine, positioning it as a potential candidate for commercial PRV vaccines. Finally, the MgB vaccine sequences were codon-optimized for in-silico cloning.
Efficacy of varying concentrations of agroforestry-derived botanical extracts on aphid (Brevicoryne brassicae) populations and yield performance in rape (Brassica napus L.)
Authors: Lawrence Mango , Morleen Nhete , Tapiwa Kugedera Andrew 
Published: September 2024

Abstract

Synthetic herbicides are becoming unaffordable for many smallholder farmers in southern Africa. In controlling pesticides, most resource-poor farmers use plant extracts, which are less expensive and environmentally friendly. The objective of this study was to evaluate the use of agroforestry crude plant extracts in the control of aphids, and growth and yield performance of Brassica napus Linnaeus. The experiment was performed in a randomized complete block design with seven treatments replicated three times. The results revealed no significant effect (p > 0.05) on aphid number per plant from the use of various concentrations of the botanical extracts and Dimethoate. However, the use of 30 g L− 1 Tephrosia vogelii or 30 g L− 1 Tagetus minuta decreased the number of aphids per plant over time. The use of T. vogelii or T. minuta for 2–8 weeks had a significant effect on Brassica napus yield at different concentrations. The highest fresh yield (9.26 ± 0.02 t ha− 1) of rape was obtained from the 30 g L− 1 T.v. concentration, and the lowest fresh yield (0.80 ± 0.64 t ha− 1) was recorded from the 10 g L− 1 T. vogelii concentration but was not significantly different from that of dimethoate (8.85 ± 0.12 t ha− 1). The T. vogelii and T. minuta concentrations reduced the aphid population and improved fresh rape yield. However, farmers are encouraged to use T. vogelii and T. minuta botanical extracts at 30 g L− 1 concentration or higher, as an economically viable aphid management strategy.
Dual-responsive Semi-IPN Hydrogels Based on Poly (N-isopropyl Acrylamide-co-Acrylic acid)/ Glycyrrhizin Cross-linked Chitosan for Controlled Drug Release
Authors: Saeedi Mostafa , Moghbeli Mohammad Reza , Vahidi Omid 
Published: September 2024

Abstract

The development of novel semi-IPN hydrogels composed of a cross-linked chitosan (CC) network and a thermo-responsive linear copolymer, i.e. poly(N-isopropyl acrylamide-co-acrylic acid) [P(NIPAM-co-AA)], with drug release capability in response to both temperature and pH changes has various potential medical applications. The thermo-responsive free copolymer chains inside the CC network were synthesized via free-radical polymerization to prepare the thermal and pH dual-responsive P(NIPAM-co-AA)/CC hydrogels with a semi-IPN structure. The prepared copolymers and semi-IPN hydrogels were characterized by FTIR, TGA, 1H and 13C NMR apparatus, and the LCST transition was determined using UV/Vis spectroscopy. The stronger C-H stretching of the semi-IPN sample at 2920 cm− 1 than the CC sample showed that the NIPAM and AA monomers successfully polymerized inside the CC network structure. TGA analysis of the semi-IPN sample exhibited peaks at 249, 379, and 290°C, corresponding to the presence of the thermo-responsive copolymer composition and the chitosan polymer, respectively. The results showed that depending on the temperature below and above the LCST, the semi-IPN hydrogel exhibited a lower (194%) and higher swelling percentage (413%) because the copolymer chain conformation changed form the coil to globule. The drug release results implied that above the LCST, the hydrogen bond between the gallic acid molecules (GA, drug model) and the semi-IPN structure may be broken, causing a change in drug release in the range of 4.5 − 39.1%. The anti-bacterial test and cytotoxicity of the selected semi-IPN sample were carried out. In an MTT assay, the highest cell viability of the semi-IPN sample with 7.5 mg/ml at 37°C was 4% more than the control group. The semi-IPN containing GA exhibited anti-bacterial action against the S aureus bacterial strain significantly. This research describes a method to prepare a smart dual-responsive semi-IPN structure with a potential for transdermal applications.
Multi-Objective Optimization of Design Parameters for Tractor Hydro-Mechanical Continuously Variable Transmissions
Authors: Zhu Zhen , Hou Rui , Zhang Hongwei , Wang Dehai , Chen Long 
Published: September 2024

Abstract

The design parameters of the transmission directly affect the vehicle's dynamics and fuel economy, due to the complexity of the tractor's working conditions and operating modes, the optimization of the transmission design parameters is more difficult. In this paper, an independently designed hydro-mechanical CVT transmission is taken as the research object, and the transmission design parameters are optimized based on the tractor's whole life-cycle speed usage rate, and the multi-objective genetic algorithm is used for optimization and solution. In this paper, the fuel consumption rate and hill climbing degree are taken as the optimization objective function, the parameters that have a greater influence on the optimization objectives are selected as the design variables, and the constraints are determined. A multi-objective genetic algorithm based on the Pareto optimality principle combined with experimental design is used to establish a multi-objective optimization model of the transmission device based on modeFrontier, and a global search for optimality is carried out, and a Pareto optimal solution is finally obtained. The results of the study find the optimal solution under the constraints, reflecting the conflicting characteristics between power and fuel economy. The design variables of the Pareto optimal solution obtained through optimization iterations based on the whole life cycle speed usage rate satisfy the matching requirements of the transmission well.
Patient Safety Competence and Second Victim Experience Among Nurses
Authors: Sun Si , Shang Shuhua , Sun Hongxia 
Published: September 2024

Abstract

Background
Nurses engage in the most direct contact with patients and face a high risk of becoming second victims.Nurses' patient safety competency is an important factor in patient safety.The relationship between second-victim patient safety competence and second-victim experience remains unclear.Hence, the objective of this study was to explore the impacts of patient safety competence on the experiences of and support provided to the second victims of adverse nursing events.
Methods
A total of 924 nurses who had experienced adverse events in four tertiary-level A hospitals in Jiangsu Province were recruited from November 03,2022 ,to April 30,2023 using the convenience sampling method; these nurses were surveyed using the SociodemographicCharacteristics Questionnaire, the Characteristics of Experiencing Adverse Events Questionnaire, the Second Victim Experience and Support Tool, and the Patient Safety Competency Self-Rating Scale.
Results
The second victim experience and support of the nurses included in this research were at moderate level, with a mean score of 2.98±0.45; psychological distress received the highestrating at 4.00±0.83 points, while coworker support received the lowest rating at 2.59±0.53 points. Nurses exhibited a higher level of patient safety competency (4.321±0.584); furthermore,patient safety competency was negatively correlated with the level of second victim distress and positively correlated with the level of second victim support, while patient safety competency was an independent factor influencing second victim experience.
Conclusion
The higher the nurse's level of patient safety competency is, the lower the level of distress and the higher the level of perceived support experienced by the second victim, thus suggesting that improving patient safety competency scan provide organizational support for the second victim and promote the second victim's recovery.
Stress and fertility decisions: Evidence from a home team’s championship victory
Authors: Cho Hyunkuk , Kim Yoonmin 
Published: September 2024

Abstract

The literature shows that in-utero maternal stress significantly decreases newborn babies’ birth weight. If this is the case, it is likely that women tend to avoid pregnancy during times of stressful events. We examined this hypothesis using a baseball home team’s championship victory when people likely gather and make a noise, which could affect emotions and stress levels. Data were taken from South Korea, where baseball is the most popular professional sport. As the championship team region changed yearly, we employed a difference-in-differences estimation method. We found that a home team’s championship win did not change the overall birth rate nine months later. However, the birth rate among women with college degrees decreased by 4.7%, while the birth rate among those without degrees remained unaffected.
JEL Classifications: D91; I10: J13; Z20
Comparison of taste threshold in postmenopausal and non-menopausal women and men
Authors: Ekhtiari Afsaneh , fard Mohammad Javad Kharazi , Jalilvand Pouya , Jafari Aryan , alaee arezoo 
Published: September 2024

Abstract

Background
One of the problems of women after menopause is the occurrence of changes in the taste sense.it could affect on reducing the quality of life .the researcher decided to conduct the present study to express this issue
Methods
This descriptive-analytical study was conducted on 113 people, including 38 menopausal women and 39 non-menopausal women and 36 men who were all qualified and matched in different factors was done. The taste threshold was evaluated by solutions of sucrose, citric acid, sodium chloride, caffeine and monosodium glutamate .The data were recorded after removing confounding items and judged through SPSS version 17 software and Kruskal-Wallis test.
Results
There was no significant difference between non-menopausal women and men in the distribution of the study subjects according to the taste threshold perception in different types of sweets (p = 0.911), but between menopausal women and non-menopausal women, as well as the group men had a significant difference and postmenopausal women had a higher taste threshold than both groups (p = 0.000) and (p-= 0.002). In the taste of sourness, there was no significant difference between non-menopausal women and men (p = 0.058), also there was no significant difference between menopausal women and men (p = 1), but there was a significant difference between menopausal women and non-menopausal women. and menopausal women had a higher taste threshold than non-menopausal women (p = 0.033). There was no significant difference between menopausal women and men in different types of umami taste (p = 1), but there was a significant difference between menopausal women and non-menopausal women, and menopausal women had a higher taste threshold than non-menopausal women (p = 0.005) Also, there was a significant difference between men and non-menopausal women, and men had a higher taste threshold than non-menopausal women (p = 0.007). There was no significant difference in the distribution of study subjects according to the taste threshold in different concentrations of saltiness and bitterness flavors in all three studied groups (p-= 0.195) (p = 0.091)
Conclusions
It seems that the taste threshold of sweet, sour and umami flavors was significantly higher in menopausal women compared to non-menopausal women.
A QR Code for the Brain: A dynamical systems framework for computing neurophysiological biomarkers
Authors: Bosl William , Enlow Michelle Bosquet , Nelson Charles 
Published: September 2024

Abstract

Neural circuits are often considered the bridge connecting genetic causes and behavior. Whereas prenatal neural circuits are believed to be derived from a combination of genetic and intrinsic activity, postnatal circuits are largely influenced by exogenous activity and experience. A dynamical neuroelectric field maintained by neural activity is proposed as the fundamental information processing substrate of cognitive function. Time series measurements of the neuroelectric field can be collected by scalp sensors and used to mathematically quantify the essential dynamical features of the neuroelectric field by constructing a digital twin of the dynamical system phase space. The multiscale nonlinear values that result can be organized into tensor data structures, from which latent features can be extracted using tensor factorization. These latent features can be mapped to behavioral constructs to derive digital biomarkers. This computational framework provides a robust method for incorporating neurodynamical measures into neuropsychiatric biomarker discovery.
Trends of Copper Homeostasis in Neoplasms,A Systemic Bibliometric from 2013 to 2023
Authors: Lin Yuhai , Lin Wenhao , Lai Yucheng , Chen Yuqiang 
Published: September 2024

Abstract

Copper dysregulation is pivotal in tumorigenesis. This study aimed to elucidate the knowledge framework of copper homeostasis within neoplasms utilizing bibliometric analysis. Publications about copper homeostasis in neoplasms from 2013 to 2023 were retrieved from the Web of Science Core Collection and PubMed databases. The bibliometric analysis was conducted using CiteSpace software, VOSviewer software and the R package "bibliometrix." A total of 1701 articles were indexed from 73 countries and regions. China has emerged as the leading country with a publication proportion of 32.45%, followed by the United States (10.35%) and India (8.41%). Significant collaborations have been conducted among Chinese academic institutions. The Journal of Inorganic Biochemistry emerged as the most prominent journal. Among the 4,841 keywords extracted from 671 journals, concepts of cell death, positron emission tomography and tumor microenvironment emerged as the most significant hotspots. This bibliometric study reviewed significant academic development and synthesized research trends on copper homeostasis in neoplasms, providing a valuable reference for scholars.
Potential role of host autophagy in Clonorchis sinensis infection
Authors: Shang Mei , Gong Yu , Luo Hui , Chen Wenjun , Wu Yinjuan , Hu Bo , Dong Huimin , Li Xuerong 
Published: September 2024

Abstract

An in vivo mouse model of Clonorchis sinensis (C. sinensis) infection with or without the administration of autophagy inhibitor chloroquine (CQ) stimulation was established to assess the possible involvement of autophagic response during C. sinensis infection. Abnormal liver function was observed at four, six, eight weeks post-infection, as indicated by elevated levels of ALT/GPT, AST/GOT, TBIL, α-SMA in the infected group. Our findings indicated C. sinensis infection activated autophagy, as shown by a decreased LC3II/I ratio and accumulated P62 expression in infected mice. Interestingly, CQ administration exhibited dual and opposing effects during the infection. In the early stage of infection, the engagement of CQ appeared to mitigates symptoms by reducing inflammation and fibrotic responses. However, in the later stage of infection, CQ might contribute to parasite survival by evading autophagic targeting, thereby exacerbating hepatic impairment and worsening liver fibrosis. Autophagy in liver was suppressed throughout the infection. These observations attested that C. sinensis infection triggered autophagy, and highlighted a complex role for CQ, with both protective and detrimental effects, in the in vivo progression of C. sinensis infection.
“I went to the primary health centre close to my workplace, but their capacity cannot deliver the baby”: Understanding factors influencing choice of providers for maternal health services in Nigeria
Authors: Akinsola Kofoworola O. , Salako Julius , Quadri Risikat , Olasupo Olabisi , Emmanuel Oluwapelumi , Bakare Oluwabunmi , King Carina , Falade Adegoke , Bakare Ayobami Adebayo 
Published: September 2024

Abstract

Background
Maternal health remains a significant public health concern globally, particularly in low- and middle-income countries such as Nigeria. Despite concerted efforts to improve maternal health services to achieve the Sustainable Development Goal of less than 70 maternal deaths per 100,000 live births by 2030, maternal mortality rates in Nigeria remain unacceptably high. Understanding the factors that shape women's choices in selecting the place of delivery could help tailor services and improve quality of care for mothers and infants. Therefore, our study seeks to understand the experiences, barriers and facilitators influencing where women choose to access maternal health services in three diverse Nigerian states: Lagos, Oyo and Jigawa.
Methods
We conducted a qualitative study using in-depth interviews with nursing mothers, healthcare workers in Lagos, Oyo and Jigawa states, and traditional birth attendants (TBAs) in Lagos and Oyo. We used maximum variation sampling to purposefully recruit nursing mothers in their puerperium who delivered in different places. Healthcare workers and TBAs were purposively selected from birth health facilities and birth homes. We used reflexive thematic analysis to generate themes across participant types and states.
Results
We identified five major themes: (1) preference for safe, comfortable and quality health services; (2) Social diffusion and cultural/religious influences; (3) Physical, geographical and financial inaccessibility; (4) Symbolic perception of health facilities and (5) Misunderstanding of health promoting and preventive care in pregnancy. The main reasons for choice of place of delivery were preference for safe, comfortable, and high-quality healthcare as well as the perceived convenience and accessibility of birth homes within close proximity to the women’s homes.
Conclusions
We found women’s choice of place of delivery is influenced by a complex interplay of factors. Prominent among these are health system inadequacies, socio-economic influences, and the desire for comfortable and quality maternal healthcare. Healthcare providers, TBAs, and nursing mothers emphasised these determinants as critical in shaping their decisions regarding where to give birth. This highlights the need for comprehensive interventions across policy, healthcare delivery, community engagement, and individual levels to overcome barriers, improve maternal health outcomes, and support women in making informed childbirth decisions.
The mechanical property changes of bridge structures using a Viscoelastic Model and Machine Learning Techniques
Authors: Nguyen Thanh Q. , Nguyen Thuy T. , Nguyen Phuoc T. 
Published: September 2024

Abstract

The article evaluates changes in the mechanical structure of a bridge using a model of a viscoelastic oscillator system. The study uses the vibration spectrum of the bridge structure through vibration signals as a research model. The vibration response spectrum of the bridge is considered in two independent states in practice, including the bending and torsional states to investigate the change in material mechanical properties. The first proposal of this study is to use the actual vibration model of the bridge to build a response spectrum that is as close to reality as possible with the support of machine learning. Using a CNN network model, the draught was optimised and enriched with information extracted from the vibration spectrum. The features of the spectrum serve as a basis for determining the existence of defects in the structure. From there, this research model allows the author to explore the influence of mechanical components on the structure through the proposed dissipation coefficient. The second proposal is to build a model of the value of the regression surface of the dissipation coefficient in the structural material. This quantity helps to evaluate the degree of data dispersion of the dissipation coefficient obtained from the response spectrum data. The study shows that the proposed quantity can evaluate the model for good practical results. In the future, this research model can be applied to many different types of structures with complex load states.
The impact of Internet use on the health status of Chinese women: the chain mediating effect of participation in cultural activities, physical exercise and social entertainment activities
Authors: Wei Pingqiang , Qin Ting , Xie Yuanyuan 
Published: September 2024

Abstract

Objective：The purpose of this study is to explore the impact of Internet use on the health status of Chinese women, and to analyze the chain mediating role of participation in cultural activities, physical exercise and social entertainment activities.
Methods：Based on the data of China General Social Survey in 2021, a total of 4469 Chinese women were selected, and multiple linear regression model, structural equation model and Bootstrap mediating effect test method were used.
Results: (1) Internet use has a positive impact on women 's health; (2) Participation in cultural activities plays an intermediary role in the impact of Internet use on women 's health status; (3) Participation in physical exercise plays an intermediary role in the impact of Internet use on women 's health status; (4) Participation in social entertainment activities plays an intermediary role in the impact of Internet use on women 's health status; (5) Participation in cultural activities, physical exercise and social entertainment activities play a chain mediating role in the impact of Internet use on women 's health status.
Conclusion: Internet use has a positive impact on the health status of Chinese women, with an average increase of 0.153 points in health status, that is, higher frequency of Internet use has a more positive impact on women 's health status. In order to maintain women 's physical and mental health, women should reasonably arrange their online time, pay attention to the quality of information, cultivate healthy living habits, actively participate in offline social activities and improve their self-management ability. At the same time, relevant departments should also strengthen Internet supervision and governance to create a safe, healthy and positive network environment for women.