bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional Profiling of Biofilm Regulators Identified by an Overexpression Screen in Saccharomyces cerevisiae
Authors: Cromie Gareth A , Tan Zhihao , Hays Michelle , Sirr Amy , Jeffery Eric W , Dudley Aimée M 
Published: July 2017

Abstract
Biofilm formation by microorganisms is a major cause of recurring infections and removal of biofilms has proven to be extremely difficult given their inherent drug resistance . Understanding the biological processes that underlie biofilm formation is thus extremely important and could lead to the development of more effective drug therapies, resulting in better infection outcomes. Using the yeast Saccharomyces cerevisiae as a biofilm model, overexpression screens identified DIG1, SFL1, HEK2, TOS8, SAN1, and ROF1/YHR177W as regulators of biofilm formation. Subsequent RNA-seq analysis of biofilm and nonbiofilm-forming strains revealed that all of the overexpression strains, other than DIG1 and TOS8, were adopting a single differential expression profile, although induced to varying degrees. TOS8 adopted a separate profile, while the expression profile of DIG1 reflected the common pattern seen in most of the strains, plus substantial DIG1-specific expression changes. We interpret the existence of the common transcriptional pattern seen across multiple, unrelated overexpression strains as reflecting a transcriptional state, that the yeast cell can access through regulatory signaling mechanisms, allowing an adaptive morphological change between biofilm-forming and nonbiofilm states.
KAJIAN KETAHANAN PANGAN RUMAH TANGGA NELAYAN BURUH DI DESA BAJO SANGKUANG KABUPATEN HALMAHERA SELATAN
Authors: Salim Fajria Dewi , Darmawaty Darmawaty 
Published: July 2017

Ketahanan pangan rumah tangga dipengaruhi oleh banyak faktor dan bervariasi antar individuataupun rumah tangga. Salah satu kelompok masyarakat di perkotaan yang masih tergolong rawanpangan adalah nelayan. Masyarakat Desa Bajo Sangkuang bermata pencahariaan utama sebagainelayan, dan mayoritas adalah menjadi buruh pada bagang perahu. Penelitian ini bertujuan untukmengetahui kondisi ketahanan pangan rumah tangga nelayan buruh di Desa Bajo Sangkuang.Penelitian ini menggunakan metode deskriptif analitis dengan pendekatan survei. Pengumpulan datadilakukan melalui wawancara menggunakan kuesioner kepada 97 rumah tangga nelayan buruh yangdipilih secara acak dan wawancara mendalam kepada informan kunci yakni kepala desa, nelayan buruh,pemilik bagang. Kondisi ketahanan pangan dianalisis dengan menggunakan indeks ketahanan panganyang dikembangkan oleh FAO. Hasil kajian menunjukkan bahwa 92,78% rumah tangga nelayan buruhdalam kategori tidak tahan pangan, sebanyak 7,22% termasuk kurang tahan pangan dan tidak adarumah tangga nelayan buruh termasuk dalam kategori tahan pangan.Title: Analysis of Household Food Security of The Fishers Labors in The Village of Bajo Sangkuang South Halmahera RegencyHousehold food security is affected by many factors and varies among individuals or households. One of the groups of people in urban areas are classified as food insecurity is the fisher. Most of the people in the Village of Bajo Sangkuang is the fishers and most of them became laborers at bagang boats. The aim of this study was to determine the food security of households of fisher workers. This study used a descriptive-analytical method with survey approach. Data were collected through interviews using a questionnaire for 97 fisher labor households as randomly selected and in-depth interviews with four keys informant such as the head of village, fishing laborers, and owner of Bagang perahu. Food security condition is analyzed using food security index by FAO. Results show that 92,78% of fishing laborers household are insecure, 7,22% are middle-secure and there is no fisher labor households are categorized as highly food security.
Complex abnormalities of urinary tract in boy with renal agenesis
Authors: Krzemień Grażyna , Szmigielska Agnieszka , Dziedzic-Jankowska Katarzyna , Warchoł Stanisław , Dudek-Warchoł Teresa , Jakimów-Kostrzewa Aleksandra 
Published: July 2017

WstępJednostronna agenezja nerki może występować jako wada izolowana lub współistnieć z innymi anomaliami rozwojowymi układu moczowego. Najczęściej rozpoznawany jest odpływ pęcherzowo-moczowodowy i wodonercze, rzadziej moczowód olbrzymi, zdwojenie moczowodu, ureterocele, ektopia nerki i spodziectwo.Opis przypadkuW pracy opisano przypadek chłopca, u którego w wieku 2,5 roku rozpoznano złożoną wadę układu moczowego – agenezję nerki lewej i ektopię nerki prawej z wodonerczem i moczowodem olbrzymim. Badanie USG wykonano z powodu bólów brzucha. Wcześniej chłopiec nie demonstrował żadnych objawów klinicznych, które mogłyby wskazywać na istnienie wady układu moczowego. Na podstawie badania izotopowego, urografii i cystouretrografii mikcyjnej rozpoznano zwężenie przypęcherzowe moczowodu. W wieku 3 lat wykonano operację przeszczepienia moczowodu metodą Cohena. Pomimo usunięcia przeszkody w odpływie moczu, utrzymywało się znacznego stopnia wodonercze ze zwężeniem warstwy miąższowej nerki. W wieku 11,5 roku u chłopca rozpoznano nadciśnienie tętnicze, w wieku 14,5 roku stwierdzono niewielki wzrost stężenia kreatyniny w surowicy i izostenurię. W ciągu 12 lat obserwacji badania ogólne i posiewy moczu były prawidłowe.WnioskiDziecko z jednostronną agenezją nerki i uropatią zaporową w drugiej nerce wymaga regularnej kontroli w poradni nefrologicznej, monitorowania ciśnienia tętniczego krwi i czynności nerki. Obecność anomalii rozwojowej w jedynej nerce może prowadzić do rozwoju przewlekłej choroby nerek i schyłkowej niewydolności nerek.
Pronóstico de la injuria renal aguda en el corto y largo plazo
Authors: Cieza Javier , Lluncor Juan , Cama Augusto 
Published: July 2017

La injuria renal aguda (IRA) adquirida en la comunidad puede tener pronóstico diferente a largo plazo que la intrahospitalaria, situación escasamente descrita. Objetivos: Comparar la supervivencia a largo plazo de pacientes con IRA con pacientes que no la tuvieron al ingresar al hospital y con pacientes en hemodiálisis crónica (HD). Materialy métodos: Se estudiaron pacientes con y sin IRA diagnosticada al momento de ser admitidos a la emergencia del Hospital Cayetano Heredia (HCH) y se comparó la supervivencia mediante curvas de Kaplan-Meier y análisis multivariado de Cox. Se comparó también con sus contemporáneos que ingresaron a HD. El período de observaciónfue entre diciembre del 2011 y el 31 de diciembre del 2015. Resultados: Fueron estudiados 47 pacientes con IRA, 93 sin IRA y 138 en HD. Las tasas de letalidad de los pacientes con y sin IRA no alcanzaron diferencia significativa a los tres (p=0,148) ni a los 35 meses (p=0,068). Hubo diferencia al comparar las tasa de letalidad entre los pacientes con IRA con los pacientes en HD (p=0,0002), pero ésta desapareció al ser normalizados los grupos por edad, albúmina sérica y ausencia de neoplasia maligna (NM) (p=0,177). En el análisis multivariado de Cox, las variables que afectaron la supervivencia fueron: edad avanzada (p=0,001), hipoalbuminemia severa (p=0,001) y coexistenciade NM (p=0,03). Conclusiones: La IRA adquirida en la comunidad no tiene efecto per se en la supervivencia de los pacientes a largo plazo. Esta es dependiente de la edad, la desnutrición y la coexistencia de NM.
The Evolution of the Cup-Cage Technique for Major Acetabular Defects
Authors: Sculco Peter K. , Ledford Cameron K. , Hanssen Arlen D. , Abdel Matthew P. , Lewallen David G. 
Published: July 2017

Background:
Complex acetabular reconstruction for major bone loss can require advanced methods such as the use of a cup-cage construct. The purpose of this study was to review outcomes after the initial development of the cup-cage technique and the subsequent evolution to the use of a half cup-cage construct.

Methods:
We performed a retrospective, single-center review of 57 patients treated with cup-cage reconstruction for major acetabular bone loss. All patients had major acetabular defects graded as Paprosky Type 2B through 3B, with 34 (60%) having an associated pelvic discontinuity. Thirty patients received a full cup-cage construct and 27, a half cup-cage construct. The mean follow-up was 5 years.

Results:
Both the full and half cup-cage cohorts demonstrated significantly improved Harris hip score (HHS) values, from 36 to 72 at a minimum of 2 years of follow-up (p < 0.05). Early construct migration occurred in 4 patients, with stabilization prior to 2-year follow-up in all but 1 patient. Incomplete, zone-3, nonprogressive acetabular radiolucencies were observed in 2 (7%) of the full cup-cage constructs and 6 (22%) of the half cup-cage constructs. One patient with a full cup-cage construct underwent re-revision of the acetabular component for progressive migration and aseptic loosening. Short-term survivorship free from re-revision for any cause or reoperation was 89% (83% and 96% for full and half cup-cage cohorts, respectively).

Conclusions:
Both full and half cup-cage constructs demonstrated successful clinical outcomes and survivorship in the treatment of major acetabular defects and pelvic discontinuity. Each method is utilized on the basis of individual intraoperative findings, including the extent and pattern of bone loss, the quality and location of host bone remaining after preparation, and the presence of pelvic discontinuity. Longer-term follow-up is required to understand the durability of these constructs in treating major acetabular defects and pelvic discontinuity.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
EGYPT, DASHUR: AN ANCIENT CO/CO2 GAS GENERATOR DISCOVERED ON THE LOWER LEVEL OF THE BENT PYRAMID OF SNEFERU
Authors: Yaroschuk A. M. 
Published: July 2017

The article researches the design and the purpose of the lower tier chamber in the Bent Pyramid of Sneferu in Dashure. The review of the earlier archeological research materials has shown that the purpose of the chamber has not been determined. In the process of the current research a technological link between the lower and the upper tiers of the pyramid has been found. It has been proven that the lower tier elements (the chamber itself, the shaft, and the chimney) all together comprised an ancient furnace – a CO/CO2 gas generator. Its purpose was to produce a mixture of carbon monoxide and carbon dioxide gas to fill the space of the upper tier of the pyramid. The goal of the architect or was to make the pyramid chambers deadly for burglars. Constructive similarities between the furnace in the lower tier of the Sneferu Pyramid and the modern CO/CO2 gas generator have been established. A theory about the presence of the secret chambers in the pyramid, including the chamber containing the Sarcophagus of the Pharaoh has been substantiated. A theory explaining the purpose of changing the shape and the construction of the Bent Pyramid specifically has been proposed.
PSYCHOLOGICAL FACTORS OF FORMATION OF SECURITY CONCEPTS IN MILITARY HIGH SCHOOL CADETS
Authors: Kostousov A. G. , Ivanov M. S. 
Published: July 2017

The article presents the results of studies on the relationship of formation of security concepts and individual psychological characteristics, such as intelligence, character traits, internality of person, value-semantic sphere of the person described as psychological factors of representations. The subjects were students of Military Institute of the Russian Federation of the National Guard troops, whose training involves the formation of military-professional competences directly related to security. Representations about security are considered as a complex semantic construct in the minds of students, is one of the basic elements of professional representations system. According to the results of statistical data, we found significant correlations between the characteristics of security concepts and the level of intelligence, lack of cusps of character traits, a meaningful life, internality personality, maturity of the system of value orientations. It is suggested that security representations is a complex construct in the mind, which is closely integrated in the individual relations, emerging in connection with the development of the whole person. It is concluded that the educational process should be improved in respect of the formation of the security concepts in military education.
THE CONFRONTATION BETWEEN THE TURKS AND THE SUI DYNASTY IN 609 – 617
Authors: Ganiev R. T. 
Published: July 2017

The article studies the events of the military confrontation between the Shibi Qaghan and Sui Dynasty in 609 – 615 AD. It shows the political situation in China whose deterioration led to the political upheaval in 617 AD and the young Tang Dynasty came to power. By the end of the Sui Dynasty period there were more than 200 organized armed gangs that were tearing the empire apart and often found support from the Turks. In 615 AD the Turks also surrounded Emperor Sui Yangdi in the fortress of Yanmen and thereby put an end to his political career. At the beginning of VII century the Eastern Turk Empire had a great military and political influence in Central Asia and posed a threat to its neighbors. Along with the separatists who opposed the Sui Dynasty, the military governor Taiyuan Li Yuan sought the assistance of the Turks. He formed an alliance with them, and the Turks supported his nomination as the new ruler of China. Thus, in the events of 609 – 617 AD the Eastern Turks played a key role, and contributed to the deterioration of the situation at the end of the Sui Dynasty as well as to the ascent to power of the future first emperor of the new Tang Dynasty, Li Yuan.
HISTORY AS MAN'S SEARCH FOR SELF-IDENTITY
Authors: Kazakov E. F. 
Published: July 2017

The article features the problem of the relationship of sense of history with the meaning of human life in general, with the life of every human being. It analyses the search for connection between the meaning of individual human existence and the sense of history, the fate of the individual and of human destiny in the Russian philosophical tradition. The meaning of history (phylogenesis) is associated with the search for self-identity. The determination occurs through realizing one’s self from the other: an animal, the dead, space, nature, God, an angel, a thing. The stages of one’s self-differentiation are the stages of one’s self-revealing. The historical deployment of self-identification process begins with reflection: man as a beast and not-beast at the same time. It forms a view of the man as a beasthuman, a human-beast, a man-not-beast. Later, one’s comparison to nature extends to infinity, beyond the Earth. The person begins to identify with outer space and the whole universe. One gets the notion of the universal man and the human universe. One begins to associate "oneself with oneself". The deployment of selfreflection allows one to differentiate "Me" from "not-Me". There develops a vision of the God-man, the man-God (the Superman). The meaning of ancestral human history is the actualization of the individual stories of each person. The purpose of world history is "my" birth.
RUSSIAN HISTORIOGRAPHY OF THE 1970-S – EARLY XXI CENTURY ON THE IDEOLOGICAL AND POLITICAL LIFE OF RUSSIA IN 1971 – 1991
Authors: Kazmina M. V. , Kazmin V. N. 
Published: July 2017

The article considers the main stages of the historiography of the ideological and political life of Russia in 1971 – 1991, the authors distinguish two stages of the historiography problems: 1971 – late 1980s - the beginning of 1990s; end 1980s - the beginning of 1990s - beginning of XXI century. The first stage is characterized by methodological monism. The main attention of researchers was paid to the problems of propaganda of Marxist-Leninist ideology, ideological and political education of Soviet citizens. The second phase of historiography was methodological revolution when there a critical re-evaluation of the historical way the Soviet State had passed took place. The main focus of historical research during Perestroika was on such problems as: dissidence, protest movement, the activities of informal organizations. The article analyzes the historiography of dissidence and concludes that researchers created a scientific base that can serve as a basis for further study of this topic.
Model postępowania sądowoadministracyjnego w Austrii
Authors: Gut Dagmara 
Published: July 2017

Artykuł dotyczy austriackiego modelu postępowania sądowoadministracyjnego, który na mocy noweli Verwaltungsgerichtsbarkeits-Novelle 2012 uległ istotnym zmianom.Od 2014 r. w Austrii funkcjonuje dwuinstancyjne sądownictwo administracyjne, obejmujące po jednym sądzie pierwszej instancji dla każdego kraju oraz dwa federalne sądy administracyjne pierwszej instancji. Sądem drugiej instancji został natomiast Trybunał Administracyjny. Zasadniczemu przekształceniu uległy także kompetencje orzecznicze sądów administracyjnych, które uzyskały możliwość podejmowania rozstrzygnięć merytorycznych. Co więcej, z powodu wprowadzenia sądów pierwszej instancji o uprawnieniach do orzekania merytorycznego, zdecydowano się na likwidację administracyjnego toku instancji. Rozwiązania przyjęte w Austrii wyznaczają kierunek rozwoju sądownictwa administracyjnego w Europie, mogą także stanowić źródło inspiracji dla polskiego ustawodawcy.
Uprawnienia pracowników w razie bezprawnego rozwiązania umowy o pracę w trybie natychmiastowym w oparciu o wybrane orzeczenia sądowe
Authors: Czekalski Piotr 
Published: July 2017

Jeżeli pracodawca rozwiązał wadliwie umowę o pracę bez wypowiedzenia pracownikowi przysługują dwa alternatywne roszczenia. Pierwszym jest żądanie przywrócenia na poprzednie warunki pracy a ponadto żądanie wynagrodzenia za czaspozostawania bez pracy. Wysokość tego żądania jest przez ustawodawcę ograniczona, jednak limity nie dotyczą niektórych kategorii pracowników, np. kobiet w ciąży. W tymwypadku wynagrodzenie przysługuje za cały okres pozostawania bez pracy. Warunkiem powrotu do pracy i uzyskania wynagrodzenia za czas nieświadczenia pracy zasądzonej mocą orzeczenia sądu jest zgłoszenie przez pracownika swojej gotowości do pracy w terminie 7 dni. Drugim uprawnieniem pracownika jest roszczenie o odszkodowanie w związku z bezprawnym rozwiązaniem umowy o pracę bez wypowiedzenia. Przedmiotem artykułu jest omówienie uprawnień, które przysługują pracownikom w razie bezprawnego rozwiązania umowy o pracę w trybie natychmiastowym.Artykuł odnosi się zarówno do osób zatrudnionych na podstawie umowy na czas określony, jak również umów bezterminowych, prezentując przykłady zaczerpnięte z orzecznictwa sądowego.
Synthesis of bis(indolyl)methanes Using Naturally Occurring, Biodegradable Itaconic Acid as a Green and Reusable Catalyst
Authors: Kasar Sandeep B. , Thopate Shankar R. 
Published: July 2017

Aim and Objective: To explore the use of naturally occurring biodegradable organic acids as a catalyst
in organic synthesis. The development of a simple, inexpensive, highly efficient yet ecofriendly catalyst
for the synthesis of bis(indolyl)methanes is explored.

Materials and Method:
A mixture of indole 1a (1.0 g, 8.53 mmol), benzaldehyde 2a (0.45 g. 4.26 mmol), and
itaconic acid (0.12 g, 0.92 mmol, 20 mol%), in H2O (5.0 mL) was refluxed at 100°C for indicated time. After
the completion of the reaction (TLC check), the reaction mixture was cooled to room temperature and extracted
with ethyl acetate (3 × 5.0 mL), organic layer was dried over Na2SO4 and concentrated under vacuum. The
crude residue was purified by column chromatography on silica gel using ethyl acetate:hexane as an eluent.

Results:
Initially optimal reaction conditions were developed for the synthesis of bis(indolyl)methanes by selecting
model reaction between indole and benzaldehyde. It was found that optimal conditions for the synthesis
of bis(indolyl)methanes are use of indole (1.0 mmol), aldehyde (0.5 mmol) and catalyst 20 mol% in water as a
solvent, under air atmosphere and at 100°C. Moreover, it was found that aqueous solution of the catalyst can be
reused with the same catalytic efficiency for ten times without any pre-treatment. This is an important achievement
with regard to the efficiency and reusability of the catalyst in synthesis.

Conclusion:
We have shown that itaconic acid in water can be used as an excellent green catalyst with high
reusability. It efficiently catalyzes electrophillic substitution reaction of indoles (ESRI) with various aldehydes
to give the corresponding BIMs in an efficient manner. Therefore, itaconic acid in water as a catalyst can be a
good alternative for the use of hazardous mineral acid and Lewis acid catalyst.
TREATMENT OF INSUFFICIENT JOINT EXTENSOR MECHANISM IN PRIMARY AND REVISION KNEE REPLACEMENT
Authors: Kulyaba T. A. , Kornilov N. N. , Mikhailova P. M. , Bovkis G. Yu. 
Published: July 2017

Insufficiency of the knee joint extensor mechanism is the absolute contraindication for total knee arthroplasty. Therefore, it is necessary to restore the extensor mechanism before arthroplasty or to change the treatment approach.Purpose of the study – to evaluate the outcomes of surgical reconstruction of the knee joint extensor mechanism during primary or revision knee arthroplasty.Materials and methods. 25 reconstructions of extensor mechanisms (24 patients) were performed in the period from 2006 to 2015. Five procedures out of 25 were performed in primary TKA and 20 in revision TKA. Indications for extensor mechanism reconstruction were as follows: patellar tendon rupture in 15 cases (60,0%), fracture of patella in 5 cases (20,0%), quadriceps tendon rupture in 3 cases (12,0%) and other indications in 2 cases (8,0%). One of the following four techniques was used to restore the extensor mechanism: “Frame / Loop” allograft of patellar tendon in 6 cases (24,0%); bone – patellar tendon – bone allograft in 9 cases (36,0%); quadriceps tendon – patella-patellar tendon – bone allografts in 7 cases (28,0%); weber’s internal fixation of patella in 3 cases (12,0%).Results. All patients were evaluated based on clinical examination, KSS and WOMAC scores (18 patients), and standard x-rays (13 patients). The mean follow-up period in the present study was 44 months postoperatively. Reconstruction of the knee joint extensor mechanism resulted in a significant reduction of pain in 38.8% of patients, the knee stability was restored in 83,3% of patients and the active knee extension improved significantly in the vast majority of patients.Conclusion. Despite the objective improvement of the knee joint function after the reconstructions of extensor mechanism, the KSS and WOMAC evaluation scores remained low which should be taken into consideration during preoperative planning.