bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra‐high pressure liquid chromatography–tandem mass spectrometry method for the determination of omarigliptin in rat plasma and its application to a pharmacokinetic study in rats
Authors: Li Meng‐Fang , Hu Xiao‐Xia , Ma Ai‐Qun 
Published: March 2017

AbstractOmarigliptin is a novel long‐acting dipeptidyl peptidase‐4 inhibitor used for the treatment of type 2 diabetes. In this work, a sensitive and selective ultra‐high pressure liquid chromatography tandem mass spectrometry method was developed and validated for the determination of omarigliptin in rat plasma. Sample preparation was performed by protein precipitation with acetonitrile. Chromatographic separation of analytes was achieved on an RRHD Eclipse Plus C18 column (2.1 × 50 mm, 1.8 μm), using gradient mobile phase (0.1% formic acid–acetonitrile) at a flow rate of 0.4 mL/min. Detection was performed in multiple reaction monitoring mode, with target fragment ions m/z 399.1 → 152.9 for omarigliptin and m/z 237.1 → 194 for the internal standard. The total run time was 4 min. Retention time of omarigliptin and internal standard was 1.25 and 2.12 min, respectively. Relative standard deviation (%) of the intra‐ and inter‐day precision was below 10.0%, and accuracy was between 97.9% and 105.3%. Calibration curve was established over the range 2–5000 ng/mL with good linearity. The lower limit of quantification and limit of detection of omarigliptin were 2 and 0.25 ng/mL, respectively. Mean recoveries were in the range 87.3–95.1% for omarigliptin. No matrix effect was observed in this method. This novel method has been successfully applied to a pharmacokinetic study of omarigliptin in rats. The absolute bioavailability of omarigliptin was identified as high as 87.31%.
Environmental Behavior and MNEs: A Strategy Pulled by Stakeholder Engagement
Authors: Delgado‐Márquez Blanca L. , Pedauga Luis Enrique 
Published: March 2017

AbstractThis research attempts to examine how multinational enterprises (MNEs) from regulated and non‐regulated industries shape their environmental strategies with regard to environmental disclosure and performance. Results reveal that regulated (non‐regulated) MNEs display worse (better) environmental performance levels and disclose less (more) environmental information than MNEs operating in non‐regulated (regulated) environments. We argue that this strategy is set as an answer to cope with legitimacy problems faced by MNEs as well as to respond to increased demands from stakeholder groups. We contend that our findings may contribute to existing literature and be of relevance for practitioners. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Cardiorespiratory fitness and risk of site‐specific cancers: a long‐term prospective cohort study
Authors: Robsahm Trude E. , Falk Ragnhild S. , Heir Trond , Sandvik Leiv , Vos Linda , Erikssen Jan , Tretli Steinar 
Published: March 2017

AbstractBased on self‐reported physical activity, there is epidemiologic evidence for a beneficial relation between physical activity and colon cancer in men, but findings for other cancers are inconclusive. Measured cardiorespiratory fitness (CRF) can provide knowledge about the cancer‐preventive value of physical activity. We aimed to assess relationships between CRF and risk of site‐specific cancers. A cohort of 1997 healthy Norwegian men, aged 40–59 years at inclusion in 1972–1975, was followed for cancer throughout 2012 using data from the Cancer Registry of Norway. CRF was measured by a maximal exercise bicycle test at inclusion. Relationships between CRF and site‐specific cancers were estimated using Cox regression, adjusted for age, body mass index, and smoking. During follow‐up, 898 cancer cases were diagnosed in 758 men. When comparing men in CRF tertile 1 with men in tertiles 2 and 3, respectively, we found decreased risk of proximal colon cancer in tertile 2 (HR: 0.30, 95% CI: 0.13–0.73) and decreased risk of cancers of lung (0.39 95% CI: 0.22–0.66), pancreas (0.32 95% CI: 0.10–1.00), and bladder (HR: 0.40 95% CI: 0.21–0.74) in tertile 3. Furthermore, a significant trend for lower risk by increasing CRF tertile was found for cancers of proximal colon, lung, and bladder (P‐value for trend <0.05). For other cancer sites, no significant association was found. Our results indicate that high midlife CRF may have cancer‐preventive value.
Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa
Authors: Angeli Anthony , Li Muchen , Dupin Lucie , Vergoten Gérard , Noël Mathieu , Madaoui Mimouna , Wang Shuai , Meyer Albert , Géhin Thomas , Vidal Sébastien , Vasseur Jean‐Jacques , Chevolot Yann , Morvan François 
Published: March 2017

AbstractLectin A (LecA) from Pseudomonas aeruginosa is an established virulence factor. Glycoclusters that target LecA and are able to compete with human glycoconjugates present on epithelial cells are promising candidates to treat P. aeruginosa infection. A family of 32 glycodendrimers of generation 0 and 1 based on a bifurcated bis‐galactoside motif have been designed to interact with LecA. The influences both of the central multivalent core and of the aglycon of these glycodendrimers on their affinity toward LecA have been evaluated by use of a microarray technique, both qualitatively for rapid screening of the binding properties and also quantitatively (Kd). This has led to high‐affinity LecA ligands with Kd values in the low nanomolar range (Kd=22 nm for the best one).
Safety and efficacy of 6‐month versus 12‐month dual antiplatelet therapy in patients after implantation of multiple biodegradable polymer‐coated sirolimus‐eluting coronary stents: Insight from the I‐LOVE‐IT 2 trial
Authors: Qi Jing , Li Yi , Li Jing , Jing Quanmin , Xu Kai , Gao Chuanyu , Ma Likun , Zhang Zhi , Xu Bo , Han Yaling 
Published: March 2017

ObjectiveThis study sought to compare the clinical outcomes of 6‐month versus 12‐month dual antiplatelet therapy (DAPT) in patients receiving multiple biodegradable polymer‐coated sirolimus‐eluting stents (BP‐SES) implants.BackgroundThe clinical outcomes for patients who undergo multiple BP‐SES implantation with different DAPT durations are uncertain.MethodsIn the I‐LOVE‐IT 2 trial, 907 patients treated with multiple BP‐SES (total stent number ≥2) were assigned to receive 6‐month (n = 440) or 12‐month (n = 467) DAPT. The primary endpoint was 12‐month target lesion failure (TLF), which is a composite of cardiac death, target vessel myocardial infarction (MI) or clinically indicated target lesion revascularization. The major secondary endpoints were 12‐month net adverse clinical events, a composite of all causes of death, MI, stroke, any revascularization and bleeding.ResultsThe number of stents per patient between the 6‐month and 12‐month DAPT group was similar (2.4 ± 0.7 vs. 2.4 ± 0.7, P = 0.47). The incidence of 12‐month TLF was comparable in the 6‐month and 12‐month DAPT groups (9.3% vs.7.5%, Log‐rank P = 0.33). However, landmark analysis showed that 12‐month DAPT, compared to 6‐month DAPT, was associated with a significantly lower risk of TLF (4.8% vs. 2.4%, Log‐rank P = 0.049) at a cost of a slightly increased risk of all bleeding events (0.5% vs. 1.7%, Log‐rank P = 0.07) between 6 and 12 months.ConclusionsIn patients treated with multiple BP‐SES, 6‐ and 12‐month DAPT had similar impacts on 12‐month clinical outcomes. Additionally, 12‐month DAPT might reduce TLF between 6 and 12 months at the cost of a slightly increased risk of all bleeding events. © 2017 Wiley Periodicals, Inc.
Chronic total occlusion is associated with a higher incidence of malapposition and uncovered stent struts: OCT findings at 6 months following DES implantation
Authors: Jia Haibo , Hu Sining , Liu Huimin , Zhu Yinchun , Zhe Chun‐yang , Li Lulu , Mustafina Irina , Hou Jingbo , Zhang Shaosong , Yu Bo 
Published: March 2017

ObjectivesTo compare stent coverage and malapposition in patients with chronic total occlusion (CTO) lesions and non‐CTO lesions (including lipid‐rich plaque [LRP] and non‐lipid‐rich plaque [non‐LRP]) after drug‐eluting stent (DES) implantation by optical coherence tomography (OCT).BackgroundDifferent initial lesion characteristics may be related to heterogeneous vessel responses after DES implantation. However, the vessel response in patients with CTO and non‐CTO lesions after stenting is unclear.Methods We retrospectively enrolled 64 patients with 68 target lesions. All of the patients underwent OCT imaging immediate after stenting and 6 months after stenting. LRP was defined as the plaque with lipid content in ≥2 quadrants. Non‐LRP consisted of fibrous, fibrocalcific plaque, and lipid plaque with less than 2 quadrants lipid content.ResultsThe malapposition (3.0%, 2.6% vs. 0.6%, P = 0.022), tissue protrusion (15.0% vs. 11.0% vs. 6.4%, P < 0.001), and intrastent thrombus (3.8% vs. 2.4% vs. 1.1%, P = 0.012) were more frequent in the CTO and LRP groups. At 6‐month follow‐up, malapposition (5.0% vs. 1.0% and 0.4%, P = 0.002) and cross sections with uncovered struts (23.4% vs. 8.2% and 6.6%, P < 0.001) were most frequently observed in the CTO group. Although the incidence of stent thrombosis was non‐significantly higher in the CTO group than the other two groups, no events were observed in patients with CTO.ConclusionsPatients with CTO lesions showed unfavorable responses to DES in the acute phase as well as at the 6‐month follow‐up, indicating the important pathological link between the original lesion morphology underneath the stents and heterogeneous artery healing. © 2017 Wiley Periodicals, Inc.
Unrecognized coronary vasospasm in patients referred for percutaneous coronary intervention: Intracoronary nitroglycerin, the forgotten stepchild of cardiovascular guidelines
Authors: Vishnevsky Alec , Julien Howard M. , Fischman David L. , Walinsky Paul , David Ogilby J. , Ruggiero Nicholas J. , Jasti Babu , Savage Michael P. 
Published: March 2017

ObjectiveThe goal of this study was to demonstrate the importance of intracoronary nitroglycerin (IC NTG) administration during diagnostic coronary angiography and prior to percutaneous coronary intervention (PCI).BackgroundPCI has been a mainstay treatment for patients with symptomatic coronary artery disease. While current guidelines emphasize the importance of periprocedural antithrombotic medications, they fail to mention the use of nitroglycerin prior to PCI.MethodsRetrospective chart and angiographic review was performed to identify patients referred for PCI who had significant angiographic stenoses that resolved after administration of IC NTG.ResultsThe study group consisted of 6 patients (3 men, 3 women) with mean age 52 ± 4years (range 46–57 years). All had anginal symptoms and significant (>70%) stenosis on diagnostic coronary angiography. None had documented ST segment elevation. The median interval between diagnostic and staged PCI procedures was 3 days. IC NTG was not administered to any of the patients at the time of diagnostic coronary angiography. In each case, repeat coronary angiography following administration of IC NTG (155 ± 46 mcg) before planned PCI demonstrated resolution of the target stenosis. PCI was deferred and all patients were successfully managed medically.ConclusionCoronary artery spasm is an under‐recognized cause of chest pain in patients with significant angiographic lesions. Coronary spasm should be suspected especially in younger patients (less than 60 years old) with apparent single vessel disease. IC NTG should be routinely administered during diagnostic angiography and before PCI to avert unnecessary coronary interventions. © 2017 Wiley Periodicals, Inc.
Oleylamine‐Stabilized Copper(0) Nanoparticles: An Efficient and Low‐Cost Catalyst for the Dehydrogenation of Dimethylamine Borane
Authors: Duman Sibel , Özkar Saim 
Published: March 2017

AbstractCopper(0) nanoparticles, in situ generated from the reduction of copper(II) 2‐ethylhexanoate during the dehydrogenation of dimethylamine borane (DMAB) at 50.0±0.1 °C in toluene solution, are active catalysts in hydrogen generation from DMAB, but not very stable against agglomeration. Addition of 5.0 equivalents of oleylamine (OAm) was found to stabilize copper(0) nanoparticles noticeably, while maintaining high catalytic activity. Oleylamine‐stabilized copper(0) nanoparticles could be isolated from the solution and characterized by XRD, TEM, UV/Vis, attenuated total reflectance (ATR)‐FTIR, and 11B NMR spectroscopies. Our report also includes (i) comparative catalytic activities of copper(0) nanoparticles in the absence and presence of OAm depending on the initial [OAm]/[Cu] ratio, catalyst concentration, substrate concentration, and temperature, (ii) the catalytic lifetime of copper(0) nanoparticles in the absence and presence of OAm in the dehydrogenation of DMAB at 50.0±0.1 °C, (iii) testing the ease of isolation and reusability of copper(0) nanoparticles in the absence and presence of OAm in the dehydrogenation of DMAB, (iv) the results of quantitative kinetic poisoning experiments by using 1,10‐phenanthroline, showing that copper(0) nanoparticles are kinetically competent catalysts in the dehydrogenation of DMAB.
Enantioselective Rauhut–Currier‐Type 1,6‐Conjugate Addition of Methyl Vinyl Ketone to para‐Quinone Methides
Authors: Kang Tian‐Chen , Wu Lu‐Ping , Yu Qi‐Wen , Wu Xin‐Yan 
Published: March 2017

AbstractAn unprecedented Rauhut–Currier‐type 1,6‐conjugate addition has been developed. With chiral cyclohexane‐based phosphine‐amide catalyst 3 h, the 1,6‐conjugate reaction has been achieved to produce chiral diarylmethine compounds in excellent yields (91–99 %) and enantioselectivities (92–98 % ee).
Manganese(I)‐Catalyzed Dispersion‐Enabled C−H/C−C Activation
Authors: Meyer Tjark H. , Liu Weiping , Feldt Milica , Wuttke Axel , Mata Ricardo A. , Ackermann Lutz 
Published: March 2017

AbstractC−H/C−C Functionalizations were achieved with the aid of a versatile manganese(I) catalyst. Thus, an organometallic manganese‐catalyzed C−H activation set the stage for silver‐free C−H/C−C transformations with ample substrate scope and excellent levels of chemo‐, site‐, and diastereo‐selectivities. The robust nature of the manganese(I) catalysis regime was reflected by the first C−H/C−C functionalization on amino acids under racemization‐free reaction conditions. Detailed experimental and computational mechanistic studies provided strong evidence for a facile C−H activation and a rate‐determining C−C cleavage, with considerable contribution from London dispersion interactions.
Anatomical segmentation of the human medial prefrontal cortex
Authors: Córcoles‐Parada M. , Müller N. C. J. , Ubero M. , Serrano‐del‐Pueblo V. M. , Mansilla F. , Marcos‐Rabal P. , Artacho‐Pérula E. , Dresler M. , Insausti R. , Fernández G. , Muñoz‐López M. 
Published: March 2017

AbstractThe medial prefrontal areas 32, 24, 14, and 25 (mPFC) form part of the limbic memory system, but little is known about their functional specialization in humans. To add anatomical precision to structural and functional magnetic resonance imaging (MRI) data, we aimed to identify these mPFC subareas in histological preparations of human brain tissue, determine sulci most consistently related with mPFC areal boundaries, and use these sulci to delineate mPFC areas in MRIs. To achieve this, we obtained three‐dimensional MRI data from 11 ex vivo hemispheres and processed them for cyto‐ and myelo‐architectonic analysis. The architectonic boundaries of mPFC areas were identified in histology and cortical surface length and volumes were measured. Unfolded maps of histologically determined boundaries were generated to identify the association of mPFC areal boundaries with sulci across cases. This analysis showed that cingulate and superior rostral were the sulci most consistently related to mPFC areal boundaries. Based on presence/absence and anastomosis between such sulci, 6 sulci patterns in the 11 hemispheres were found. A further analysis of 102 hemispheres of in vivo MRI scans (N = 51 males, mean ± SD 24.1 ± 3.1 years of age) showed similar sulci patterns, which allowed us to delineate the mFPC areas in them. The volumes of mPFC areas across histological, ex vivo and in vivo MRI delineations were comparable and probabilistic maps generated from the MRIs of the102 hemispheres. Probabilistic maps of mPFC areas were registered to MNI space and are available for regional analysis of functional magnetic resonance imaging data.
Cytosine Radical Cations: A Gas‐Phase Study Combining IRMPD Spectroscopy, UVPD Spectroscopy, Ion–Molecule Reactions, and Theoretical Calculations
Authors: Lesslie Michael , Lawler John T. , Dang Andy , Korn Joseph A. , Bím Daniel , Steinmetz Vincent , Maître Philippe , Tureček Frantisek , Ryzhov Victor 
Published: March 2017

AbstractThe radical cation of cytosine (Cyt.+) is generated by dissociative oxidation from a ternary CuII complex in the gas phase. The radical cation is characterized by infrared multiple photon dissociation (IRMPD) spectroscopy in the fingerprint region, UV/Vis photodissociation (UVPD) spectroscopy, ion–molecule reactions, and theoretical calculations (density functional theory and ab initio). The experimental IRMPD spectrum features diagnostic bands for two enol‐amino and two keto‐amino tautomers of Cyt.+ that are calculated to be among the lowest energy isomers, in agreement with a previous study. Although the UVPD action spectrum can also be matched to a combination of the four lowest energy tautomers, the presence of a nonclassical distonic radical cation cannot be ruled out. Its formation is, however, unlikely due to the high energy of this isomer and the respective ternary CuII complex. Gas‐phase ion–molecule reactions showed that Cyt.+ undergoes hydrogen‐atom abstraction from 1‐propanethiol, radical recombination reactions with nitric oxide, and electron transfer from dimethyl disulfide.
Confirming a plant‐mediated “Biological Tide” in an aridland constructed treatment wetland
Authors: Bois Paul , Childers Daniel L. , Corlouer Thomas , Laurent Julien , Massicot Antoine , Sanchez Christopher A. , Wanko Adrien 
Published: March 2017

AbstractAs urban populations grow and the need for sustainable water treatment increases, urban constructed treatment wetlands (CTWs) are increasingly being used and studied. However, less is known about the effectiveness of this “turquoise infrastructure” in arid climates. In a recent publication, we presented evidence of plant‐mediated control of surface hydrology, using a water budget approach, in a CTW in Phoenix, Arizona, USA. We also demonstrated how this transpiration‐driven wetland surface flow made this treatment marsh more effective at pollutant removal than its counterparts in cooler or more mesic environments. Water budget‐based calculations estimated that nearly 20% of the water overlying the marsh was transpired daily by the plants (40–60 L·m−2·d−1) during the hottest summer months. We estimated the associated water velocity to be about 40 cm/h. In this paper, we report on hydrodynamic experiments that confirmed the existence of this phenomenon that we refer to as the “Biological Tide,” and verified the rate at which transpiration by the marsh vegetation moves surface water into the biogeochemically active marsh. We combined a water budget‐based approach and dye tracer experiments to quantify and confirm this phenomenon. Because of the low velocities estimated from our water budget approach (a few cm/h), we used a fixed‐wall flowthrough marsh flume to limit the lateral dye movement during the tracer experiments. We measured actual flow rates of 7–50 cm/h (with 5–8% precision) during these experiments, which closely conformed to the values estimated from our water budget‐based approaches. The flow was largely dispersive due to the extensive impedance imparted by dense plant stems in the marsh. From these summer flow rates, we calculated that residence time of the water overlying the marsh in this CTW averaged about 13 d, but could be as low as four days. Again, these values were reasonably close to the 15–20% replacement rate for marsh water we estimated using the water budget approach. This is the first time, to our knowledge, that plant‐mediated biological control of surface hydrology in a wetland, without connection to groundwater, has been reported.
Characterization and comparison of UK, Irish, and French cold pressed rapeseed oils with refined rapeseed oils and extra virgin olive oils
Authors: McDowell Daniel , Elliott Christopher T. , Koidis Anastasios 
Published: March 2017

Various chemical parameters were used to characterize a wide range of cold pressed rapeseed oils and to contrast the findings with refined rapeseed and extra virgin olive oil. There were significant differences between cold pressed rapeseed oils regarding almost all measured parameters. Volatile composition analysis showed that hexanal, 3‐methyl pentane and 1‐butene, 4‐isothiocyanato were the most abundant compounds. There was no correlation between volatile compounds and geographical region of cold pressed rapeseed oils. French cold pressed rapeseed oils were found in exhibit significantly higher antioxidant activity levels than cold pressed rapeseed oils from other regions. Refined rapeseed oil was found to have a higher antioxidant activity but have significantly lower levels of phenolic acids (0.008 mg/kg oil) than cold pressed rapeseed oil (0.46 mg/kg oil). These phenolic acids appear to be important for oxidative stability as cold pressed rapeseed oil was more stable under heat stress than refined rapeseed oil. Olive oil was the most stable under heat stress, largely due to its comparatively high saturated fat content. Antioxidant potential, phenolic acids and peroxide values were found to be the main factors differentiating cold pressed rapeseed oil from refined rapeseed oil.Practical applications: Cold pressed rapeseed oil is a relatively new oil to the market and this study is the first to examine oils available to the British, Irish and French consumers. It shows the compositional variation of oils on the market by analyzing many parameters important for oil quality and consumer palatability. Antioxidant behavior and phenolic acid identification indicate potential health benefiting properties. This research also compares cold pressed rapeseed oils with market competitors which allows for clear comparison of these widely used edible oils.Cold pressed rapeseed oil is made by mechanically crushing rapeseeds at a low temperature, followed by filtering and bottling the oil. This work investigates the chemical composition of cold pressed rapeseed oil, along with its antioxidant capacity and stability under heat stress. Cold pressed rapeseed oil is also compared to market competitors; refined rapeseed oil and extra virgin olive oil.
PlasmonicAu‐TiO2/ZnOCore–Shell Nanorod Array Photoanode for Visible‐Light‐Driven Photoelectrochemical Water Splitting
Authors: Hu Sujuan , Wang Baoling , Zhu Mingshan , Ma Yinhai , Wang Jiao 
Published: March 2017

AbstractA plasmonic Au‐TiO2/ZnO core–shell nanorod array (NR) photoanode exhibits efficient photoelectrochemical water splitting induced by the plasmonic energy and type II TiO2/ZnO heterojunction. The plasmonic Au‐TiO2/ZnO core–shell NR photoanode provides a photocurrent density of 3.01 mA cm−2 at 1.7 V versus the reversible hydrogen electrode (RHE), almost 1.5 and 3 times higher than that of TiO2/ZnO core–shell NRs and TiO2 NRs upon exposure into simulated solar light. Moreover, the plasmonic Au‐TiO2/ZnO core–shell NR photoanode shows a clear photocurrent density under visible‐light irradiation (λ>400 nm) with a photocurrent density of 0.11 mA cm−2 at 1.23 V vs. RHE. The visible‐light‐excited photocurrent is mainly caused by the surface plasmon resonance effects produced by plasmonic Au nanoparticles, which benefit the visible‐light absorption and charge separation of the wide‐band‐gap TiO2/ZnO heterojunction through the electrons and resonant energy transfer. Additionally, the strong interfacial interaction between TiO2 and ZnO leads to an effective photoinduced interfacial charge separation and transfer.