bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oocyte competence in in vitro fertilization and intracytoplasmic sperm injection patients suffering from endometriosis and its possible association with subsequent treatment outcome: a matched case–control study
Authors: Shebl Omar , Sifferlinger Ida , Habelsberger Alwin , Oppelt Peter , Mayer Richard B. , Petek Erwin , Ebner Thomas 
Published: June 2016

AbstractIntroductionEndometriosis affects up to 15% of women of reproductive age. There is an obvious lack of studies dealing with morphological parameters of oocyte morphology in endometriosis patients in assisted reproduction. One aim of the study is to describe oocyte morphology in patients undergoing intracytoplasmic sperm injection suffering from endometriosis. In addition, the impact of endometriosis on in vitro fertilization results is analyzed. Both in vitro fertilization and intracytoplasmic sperm injection patients are then matched with an endometriosis‐free control group for highlighting the possible association of endometriosis with pregnancy outcome.Material and methodsOocyte morphology of endometriosis patients was assessed in two groups. Both study group and control group consisted of 129 in vitro fertilization/intracytoplasmic sperm injection cycles each. Patients were matched according to anti‐Müllerian hormone, female age, previous treatment cycles, and method of fertilization. Endometriosis was graded according to the revised American Society for Reproductive Medicine guidelines of 1997.ResultsPatients with endometriosis had a significantly lower rate of mature oocytes (p < 0.03) and morphologically normal oocytes (p < 0.001). In particular, brownish oocytes (p < 0.009; stage I–IV) and the presence of refractile bodies (p < 0.001; stage IV) were found to be increased. Endometriosis stage IV was associated with significantly worse‐quality oocytes than stages I–III (p < 0.01). Fertilization was significantly reduced in conventional in vitro fertilization but not in intracytoplasmic sperm injection (p < 0.03). This was due to lower fertilization rates in stage III–IV endometriosis compared with stage I–II (p < 0.04). No difference was observed with respect to rates of implantation, clinical pregnancy, miscarriage, live birth, and malformation.ConclusionsEndometriosis patients, in particular those with severe endometriosis, present lower‐quality oocytes. Once fertilized, no impairment of further preimplantation embryo development and pregnancy outcome right up to healthy live birth rate has to be expected.
Reproducibility of the water‐drinking test in patients with exfoliation syndrome and exfoliative glaucoma
Authors: Özyol Erhan , Özyol Pelin , Karalezli Aylin 
Published: June 2016

AbstractPurposeTo evaluate the reproducibility of intraocular pressure (IOP) peaks and fluctuations detected during the water‐drinking test (WDT) in patients with exfoliation syndrome (XFS) and exfoliative glaucoma (XFG).MethodsThis prospective study included 34 XFS and 30 XFG patients. Each patient was evaluated twice, with the two WDTs performed on a 30‐day interval. We recorded IOP peak (highest IOP during the WDT) and IOP fluctuation (IOP peak minus IOP before the test). Bland–Altman analysis was applied to assess the agreement of IOP peaks and fluctuations between the two consecutive visits. We defined reproducible as within 4 mmHg for IOP peak and within 2 mmHg for IOP fluctuation.ResultsThere were no significant differences in IOP values, IOP peaks and IOP fluctuations between the two visits for both XFS and XFG patients (p > 0.05, for all). The coefficient of repeatability for IOP peak was 2.5 mmHg and 3.5 mmHg in XFS and XFG patients respectively and for IOP fluctuation, it was 2.1 mmHg and 2.2 mmHg. None of the XFS or XFG patients had an IOP peak difference higher than 4 mmHg. Intraocular pressure (IOP) fluctuation differences above 2.0 mmHg were found in 8.8% of XFS patients and 16.6% of XFG patients.ConclusionsIntraocular pressure (IOP) peak and IOP fluctuation have a reproducibility, both in XFS and in XFG.
Cardiovascular effects of cyclooxygenase‐2 inhibitors: a mechanistic and clinical perspective
Authors: Patrono Carlo 
Published: June 2016

Linked ArticlesThis article is part of a joint Themed section with the British Journal of Pharmacology on Targeting Inflammation to Reduce Cardiovascular Disease Risk: a Realistic Clinical Prospect? The rest of the Themed section will appear in a future issue of BJP and will be available at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1476‐5381Prostaglandin (PG) H synthase 2 [also referred to colloquially as cyclooxygenase (COX) 2] represents a key enzyme in arachidonic acid metabolism in health and disease. It is both constitutively expressed in several human tissues (e.g. kidney and brain) and induced in various cell types (including monocytes/macrophages, vascular endothelial cells and colorectal cancer cells) in response to inflammatory cytokines, laminar shear stress and growth factors. Products of COX‐2 activity (e.g. PGE2 and prostacyclin) are involved in diverse physiological and pathophysiological processes, including renal haemodynamics and the control of blood pressure, endothelial thromboresistance, pain and inflammation, and colorectal tumorigenesis. Therefore, it is not surprising that COX‐2 inhibitors display multifaceted clinical effects, ranging from reduced pain and inflammation to increased blood pressure, an increased risk of atherothrombotic events and a decreased risk of colorectal cancer. The aim of the present article was to review the cardiovascular effects of COX‐2 inhibitors [traditional nonsteroidal anti‐inflammatory drugs (tNSAIDs) and coxibs alike], with a focus on the mechanisms contributing to the clinical readouts of COX‐2 inhibition.
Unhealthy behaviour modification, psychological distress, and 1‐year survival in cardiac rehabilitation
Authors: Gostoli Sara , Roncuzzi Renzo , Urbinati Stefano , Morisky Donald E. , Rafanelli Chiara 
Published: June 2016

ObjectiveCardiac rehabilitation (CR) is considered the recommended secondary prevention treatment for cardiovascular diseases (CVD), in terms of health behaviours and, secondarily, better cardiac outcomes promotion. However, the role of psychiatric and psychosomatic distress on the efficacy of CR is unclear. This research aimed to evaluate the impact of CR on unhealthy behaviour modification and cardiac course, considering the moderating role of depression, anxiety, and psychosomatic syndromes.DesignA longitudinal design between and within groups was employed. The assessment was repeated four times: at admission to CR (T1), at discharge (T2), 6 (T3) and 12 months following CR completion (T4).MethodOne hundred and eight patients undergoing CR versus 85 patients with CVD not referred to CR, underwent psychiatric, psychosomatic, and health behaviour assessment. The assessment included the Structured Clinical Interview for DSM‐IV (depression and anxiety), the interview based on Diagnostic Criteria for Psychosomatic Research, GOSPEL Study questionnaire (health behaviours), Pittsburgh Sleep Quality Index, and 8‐item Morisky Medication Adherence Scale.ResultsCardiac rehabilitation was associated with maintenance of physical activity, improvement of behavioural aspects related to food consumption, stress management, and sleep quality. On the contrary, CR was not associated with weight loss, healthy diet, and medication adherence. Depression and psychosomatic syndromes seem to moderate the modification of specific health‐related behaviours (physical activity, behavioural aspects of food consumption, stress management, and pharmacological adherence).ConclusionIn CR settings, an integrated assessment including both psychiatric and psychosomatic syndromes is needed to address psychological factors associated with unhealthy behaviour modification.

Statement of contribution

What is already known on this subject?

Cardiac rehabilitation (CR) is considered a class 1A treatment recommendation and the most cost‐effective model of secondary prevention to reduce cardiovascular events.

There is evidence about the association between psychological distress and both unhealthy behaviour and cardiac course.

Depression and psychosomatic distress, such as type A behaviour and demoralization, are frequently associated with CVD course. However, the role of psychiatric and psychosomatic distress in CR is not well known.

What does this study add?

CR exerted a protective effect on physical activity and a positive effect on eating behaviour, stress management, and quality of sleep.

CR did not show any particular effect on smoking, overweight/obesity, dietary habits, medication adherence, and patients’ 1‐year survival.

Findings from this study suggest the importance to consider specific psychological and psychosomatic aspects in affecting lifestyle.
Minority acculturation and peer rejection: Costs of acculturation misfit with peer‐group norms
Authors: Celeste Laura , Meeussen Loes , Verschueren Karine , Phalet Karen 
Published: June 2016

How do minority adolescents’ personal acculturation preferences and peer norms of acculturation affect their social inclusion in school? Turkish and Moroccan minority adolescents (N = 681) reported their preferences for heritage culture maintenance, mainstream culture adoption, and their experiences of peer rejection as a key indicator of adjustment problems. Additionally, we aggregated peer acculturation norms of maintenance and adoption within ethnically diverse classrooms (N = 230 in 50 Belgian schools), distinguishing between co‐ethnic (Turkish or Moroccan classmates only,N = 681) and cross‐ethnic norms (also includingN = 1,930 other classmates). Cross‐ethnic peer‐group norms (of adoption and maintenance) and co‐ethnic norms (of maintenance, marginally) predicted minority experiences of peer rejection (controlling for ethnic composition). Moreover, misfit of minorities’ own acculturation preferences with both cross‐ethnic and co‐ethnic peer‐group norms was harmful. When cross‐ethnic norms stressed adoption, ‘integrationist’ minority youth – who combined culture adoption with maintenance – experienced most peer rejection. Yet, when co‐ethnic peers stressed maintenance, ‘assimilationist’ minority youth experienced most rejection. In conclusion, acculturation misfit with peer‐group norms is a risk factor for minority inclusion in ethnically diverse environments.
Cardioprotective effect of novel sulphonamides‐1,3,5‐triazine conjugates against ischaemic–reperfusion injury via selective inhibition of MMP‐9
Authors: Zheng Xiao‐Zhu , Zhou Jia‐Li , Ye Jing , Guo Pei‐Pei , Lin Chun‐Shui 
Published: June 2016

Diseases affecting cardiovascular system are ranked as a top most cause of morbidity and mortality. Herein, a novel class sulphonamides‐1,3,5‐triazine conjugates have been synthesized and tested for inhibitory activity against MMP‐2 and MMP‐9. The results of the study showed that these molecules efficiently inhibit MMP‐9 than MMP‐2, revealing compound 8e as the most potent inhibitor (IC50 = 2.34 ± 0.56 nm). Due to involvement of MMP‐9 in many cardiovascular diseases, particularly in myocardial ischaemia (MI), compound 8e was further subjected for the determination of the protective effect on isoproterenol (ISO)‐induced myocardial injury in rats.
Synthesis and anti‐Candida activity of novel benzothiepino[3,2‐c]pyridine derivatives
Authors: Božinović Nina , Šegan Sandra , Vojnovic Sandra , Pavic Aleksandar , Šolaja Bogdan A. , Nikodinovic‐Runic Jasmina , Opsenica Igor M. 
Published: June 2016

A novel series of thiepine derivatives were synthesized and evaluated as potential antimicrobials. All the synthesized compounds were evaluated for their antimicrobial activities in vitro against the fungi Candida albicans (ATCC 10231), C. parapsilosis (clinical isolate), Gram‐negative bacterium Pseudomonas aeruginosa (ATCC 44752), and Gram‐positive bacterium Staphylococcus aureus (ATCC 25923). Synthesized compounds showed higher antifungal activity than antibacterial activity, indicating that they could be used as selective antimicrobials. Selected thiepines efficiently inhibited Candida hyphae formation, a trait necessary for their pathogenicity. Thiepine 8‐phenyl[1]benzothiepino[3,2‐c]pyridine (16) efficiently killed Candida albicans at 15.6 μg/mL and showed no embryotoxicity at 75 μg/mL. Derivative 8‐[4‐(4,5‐dihydro‐1H‐imidazol‐2‐yl)phenyl][1]benzothiepino[3,2‐c]pyridine (23) caused significant hemolysis and in vitro DNA interaction. The position of the phenyl ring was essential for the antifungal activity, while the electronic effects of the substituents did not significantly influence activity. Results obtained from in vivo embryotoxicity on zebrafish (Danio rerio) encourage further structure optimizations.
Parent‐related mechanisms underlying the social gradient of childhood overweight and obesity: a systematic review
Authors: Mech P. , Hooley M. , Skouteris H. , Williams J. 
Published: June 2016

AbstractBackgroundLow socio‐economic status (SES) is a significant risk factor for childhood overweight and obesity (COWOB) in high‐income countries. Parents to young children buffer and accentuate social and cultural influences, and are central to the development of this disease. An understanding of the parent‐related mechanisms that underlie the SES–COWOB relationship is needed to improve the efficacy of prevention and intervention efforts.ObjectiveA systematic review of relevant literature was conducted to investigate the mechanisms by which levels of SES (low, middle and high) are associated to COWOB, by exploring mediation and interaction effects.MethodSix electronic databases were searched yielding 5155 initial records, once duplicates were removed. Studies were included if they investigated COWOB, SES, parent‐related factors and the multivariate relationship between these factors. Thirty studies were included. Factors found to be mediating the SES–COWOB relationship or interacting with SES to influence COWOB were categorized according to an ecological systems framework, at child, parent, household and social system level factors.ResultsHigh parent body mass index, ethnicity, child‐care attendance, high TV time (mother and child), breastfeeding (early weaning), food intake behaviours and birthweight potentially mediate the relationship between SES and COWOB. Different risk factors for COWOB in different SES groups were found. For low SES families, parental obesity and maternal depressive symptoms were strong risk factors for COWOB, whereas long maternal working hours and a permissive parenting style were risk factors for higher SES families. None of the studies investigated parental psychological attributes such as attitudes, beliefs, self‐esteem and so on as potential mechanisms/risk factors.ConclusionsFamilies from different SES groups have different risk and protective factors for COWOB. Prevention and intervention efforts may have improved efficacy if they are tailored to address specific risk factors within SES.
Controlling and Autonomy‐Supportive Parenting in the United States and China: Beyond Children's Reports
Authors: Cheung Cecilia S. , Pomerantz Eva M. , Wang Meifang , Qu Yang 
Published: June 2016

Research comparing the predictive power of parents’ control and autonomy support in the United States and China has relied almost exclusively on children's reports. Such reports may lead to inaccurate conclusions if they do not reflect parents’ practices to the same extent in the two countries. A total of 394 American and Chinese children (Mage = 13.19 years) and their mothers reported on mothers’ controlling and autonomy‐supportive parenting in the academic arena; trained observers coded such parenting in the laboratory. Children's reports were associated modestly with mothers’ reports and weakly, if at all, with observers’ reports in both the United States and China. Parenting predicted children's academic and emotional functioning similarly in the two countries, irrespective of reporter.
Pretty as a Princess: Longitudinal Effects of Engagement With Disney Princesses on Gender Stereotypes, Body Esteem, and Prosocial Behavior in Children
Authors: Coyne Sarah M. , Linder Jennifer Ruh , Rasmussen Eric E. , Nelson David A. , Birkbeck Victoria 
Published: June 2016

This study examined level of engagement with Disney Princess media/products as it relates to gender‐stereotypical behavior, body esteem (i.e. body image), and prosocial behavior during early childhood. Participants consisted of 198 children (Mage = 58 months), who were tested at two time points (approximately 1 year apart). Data consisted of parent and teacher reports, and child observations in a toy preference task. Longitudinal results revealed that Disney Princess engagement was associated with more female gender‐stereotypical behavior 1 year later, even after controlling for initial levels of gender‐stereotypical behavior. Parental mediation strengthened associations between princess engagement and adherence to female gender‐stereotypical behavior for both girls and boys, and for body esteem and prosocial behavior for boys only.
H-ferritin and CD68+/H-ferritin+ monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease
Authors: Ruscitti P , Cipriani P , Ciccia F , Di Benedetto P , Liakouli V , Berardicurti O , Carubbi F , Guggino G , Di Bartolomeo S , Triolo G , Giacomelli R 
Published: June 2016

Summary
Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein composed of 24 subunits, heavy (H) subunits and light (L) subunits. The ferritin enriched in L subunits (L-ferritin) and the ferritin enriched in H subunits (H-ferritin) may be observed in different tissues. In this work, we aimed to investigate the skin expression of both H-and L-ferritin and the number of macrophages expressing these molecules from AOSD patients with persistent cutaneous lesions. We observed an increased expression of H-ferritin in the skin, associated with an infiltrate in the biopsies obtained from persistent cutaneous lesions of AOSD patients. Furthermore, a positive correlation between H-ferritin skin levels as well as the number of CD68+/H-ferritin+ cells and the multi-visceral involvement of the disease was observed. Our data showed an increased expression of H-ferritin in the skin of AOSD patients, associated with a strong infiltrate of CD68+/H-ferritin+ cells. Furthermore, a correlation between the levels of H-ferritin as well as of the number of CD68+/H-ferritin+ cells and the multi-visceral involvement of the disease was observed.
Hydrophilic surface of Ti6Al4V‐ELI alloy improves the early bone apposition of sheep tibia
Authors: Sartoretto Suelen C. , Alves Adriana T. N. N. , Zarranz Laila , Jorge Mônica Z. , Granjeiro José M. , Calasans‐Maia Mônica D. 
Published: June 2016

AbstractObjectiveThe aim of this preclinical study was to compare histologically and histomorphometrically both sandblasted/acid‐etched implant surfaces with or without maintained in an isotonic solution of 0.9% sodium chloride in early stages of osseointegration.Material and methodsBoth implant surfaces were composed of a titanium/aluminum/vanadium alloy (Ti6Al4V‐ELI), but they had different surface chemistries: sandblasted/acid‐etched titanium surface (FN) or sandblasted/acid‐etched surface maintained in an isotonic solution of 0.9% sodium chloride (FA). The surface morphology, topography and chemistry were evaluated by scanning electron microscopy (SEM), confocal microscopy (CM) and X‐ray photoelectron spectroscopy (XPS), respectively. Dynamic contact angle (DCA) was employed for wettability evaluation. One implant from each group was placed in the left tibia of twenty healthy, skeletally mature Santa Ines sheep (n = 5). Bone area (BA) and bone‐to‐implant contact (BIC) were performed on thin sections (30 μm) at 7, 14, 21 and 28 days after implant installation.ResultsDespite the roughness and morphology similarities between the groups, at the XPS evaluation, the FA group presented 2.3 times less carbon on the surface (FN: 27.3% and FA: 11.6%), sharply enhanced hydrophilicity and significantly enhanced BA and BIC at 14, 21 and 28 days of healing (P < 0.05) compared with the FN.ConclusionThe data suggest that the hydrophilic FA accelerates the BA apposition and BIC interface around the implants during early stages of bone formation, providing highest degree of osseointegration.
The lymph node ratio does not provide additional prognostic information compared with the N1/N2 classification in Stage III colon cancer
Authors: Mohan H. M. , Walsh C. , Kennelly R. , Ng C. H. , O'Connell P. R. , Hyland J. M. , Hanly A. , Martin S. , Gibbons D. , Sheahan K. , Winter D. C. 
Published: June 2016

AbstractAimThe ratio of positive nodes to total nodes, the lymph node ratio (LNR), is a proposed alternative to the current N1/N2 classification of nodal disease. The true clinical benefit of adopting the LNR, however, has not been definitively demonstrated. This study compared the LNR with the current N1/N2 classification of Stage III colon cancer.MethodPatients with Stage III colon cancer were identified from a prospectively maintained database (1996–2012). The specificity and sensitivity of the N1/N2 classification in the prediction of overall survival were determined using R. A cut‐off point for the LNR was determined by setting the specificity the same as for the N1/N2 classification. The sensitivity of the two methods was then compared, and bootstrapping 1000‐fold was performed. This was then repeated for disease‐specific survival.ResultsThe specificity and sensitivity of the N1/N2 classification in predicting 3‐year overall survival in this cohort (n = 402) was 62.2% and 52.1%, respectively. The cut‐off point for the LNR was determined to be 0.27 for these data. On comparing LNR with the N1/N2 classification showed that for a given specificity, the LNR did not provide a statistically significant improvement in sensitivity (52.8% vs 52.1%, P = 0.31). For disease‐specific death at 3 years, the specificity and sensitivity were 60.8% and 54.6%, respectively. The LNR did not provide a statistically significant improvement (55.4% vs 54.6%, P = 0.44).ConclusionBoth the N1/N2 system and the LNR predict survival in colon cancer, but both have low specificity and sensitivity. The LNR does not provide additional prognostic value to current staging for overall or disease‐specific survival for a given cut‐off point.