bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДОЛГОСРОЧНЫЕ ТРЕНДЫ РЫНКА СЫРЬЯ В РОССИИ ДЛЯ ПРОИЗВОДСТВА БИОЭТАНОЛА
Authors: Сидак М.В. 
Published: October 2024

Рассмотрены предпосылки развития рынка сырья для производства биоэтанола. Проанализированы последствия государственных мер поддержки АПК, введенных ограничений экспорта, фиксации цен, а также представлены два сценария развития ситуации на российском аграрном рынке, дан прогноз балансов производства зерна и сахара в сезоне 2021/2022. Предложены пути решения для стабилизации внутренних цен и проблемы перепроизводства на отечественном сельскохозяйственном рынке.
Prerequisites for the development of the market of raw materials for bioethanol production are considered. The consequences of state measures of support the agroindustrial complex, imposed export restrictions, price fixing are analyzed, and two scenarios of the situation in Russian agrarian market are presented, the forecast of grain and sugar production balances in the 2021/2022 season is given. The ways of solving the problem of domestic price stabilization and overproduction in the domestic agricultural market are proposed.
Development of strategic management accounting of innovation capital based on a balanced scorecard system
Authors: Makarovych V.K. 
Published: October 2024

The essence of the balanced scorecard system as a means of providing information for the innovative management of the enterprise has been considered. The functions of a balanced scorecard system in the system of innovative management have been disclosed. The role of a balanced scorecard system in the formation of information support for the management of the enterpriseʼs innovative capital has been analyzed. The factors that determine the need for the development of a balanced scorecard system in the conditions of the knowledge economy have been analyzed. Four main options for the reorganization of the balanced scorecard system for the accounting support of the management of the innovative capital of the enterprise have been identified and analyzed: 1) inclusion of innovative indicators in the existing prospects of balanced scorecard system; 2) renaming the individual balanced scorecard system perspectives; 3) highlighting a new «innovative» perspective; 4) creation of an innovative scorecard system. The advantages and disadvantages of each of the proposed options for the development of a balanced scorecard system from the standpoint of building a system of accounting support for the management of innovative capital at Ukrainian enterprises have been grounded.
ANALISIS KUALITAS PRODUK FURNITURE DI MESIN MARUNAKA DENGAN MENGGUNAKAN METODE QUALITY CONTROL CIRCLE (QCC)
Authors: Supriyanto Supriyanto 
Published: October 2024

PT. NIJ Gresik merupakan perusahaan yang bergerak dibidang manufaktur. Produk yang dihasilkan oleh PT. NIJ gresik adalah furniture. PT. NIJ Gresik berdiri sejak tahun 2007 dan melakukan perluasan di Kediri tahan 2010. Dan pada tahun 2020 mendirikan di Pekalongan. Lingkup pemasaran PT. NIJ Gresik berada dikawasan asia dan sekitrnya. Adapun standar toleransi kecacatan yang ditentukan perusahaan dalam memproduksi furniture sebesar 1,5%, namun kecacatan yang diakibatkan dari proses produksi pada PT. NIJ Gresik ±2%. Tujuan penelitian ini adalah untuk menganalisis pelaksanaan kualitas dengan menggunakan quality control circle (qcc) dan melakukan identifikasi faktor apa yang dominan terjadinya kerusakan pada produk furniture PT. NIJ Gresik. Penggunaan alat bantu dengan peta kendali control,histogram,diagram pareto, Dalam pengendalian kualitas produk dapat mengidentifikasikan bahwa ternyata kualitas produk berada di luar batas kendali. Sedangkan diagram pareto, prioritas perbaikan yang perlu dilakukan oleh PT. NIJ Gresik untuk menekan atau mengurangi jumlah kecacatan yang terjadi, dalam produksi jenis kecacatan cacat gores yang lebih dominan dengan 71,8% maka dari itu menjadi prioritas utama dalam perbaikan. Dari analisa diagram fishbone dapat diketahui faktor terjadinya kecacatan dalam produk antara lain dari faktor manusia, mesin, metode kerja, material dan lingkungan kerja.
Development of Integrated Science Teaching Materials of Al-Quran Verses in Improving Students' Religious Attitudes in Madrasas
Authors: Kadir Abdul , Assingkily Muhammad Shaleh , Jahidin  , Sufiani  , Samputri Salma , Ahmad Mustapa 
Published: October 2024

Various previous studies have responded to the study of the challenges of moral degradation in the digital era. However, the focus of the study has not yet been found in the form of the integrality of Qur'anic verse-based Learning with a locus in Madrasah Tsanawiyah. It is believed that this integrality fosters students' religious attitudes. This study aims to develop a product of integrated science teaching materials of the Qur'anic verses to improve students' religious attitudes in madrasah. This type of research is research and development (R&D), adapting the Borg & Gall model with the ADDIE stages, analysis, design, development, implementation, and evaluation, because it is considered relevant to describe the chronology of Learning product development from the beginning. The results of this study found that science teaching materials integrated with al-Qur'an verses are valid and very feasible to use in student science Learning at MTsN Konawe Regency with an average value of 91.98% of the validity test results. Then, science teaching materials integrated with al-Qur'an values have a practicality value to be applied at MTsN Konawe Regency, marked by the average score of 1.64 small groups and 1.79 large groups. Science teaching materials integrated with al-Qur'an values are effectively used in science Learning after being developed in small and large groups with a probability value (r) Sig. = 0.000 <a = 0.05, meaning there is a significant difference in students' spiritual attitudes before and after treatment using science teaching materials integrated with the Qur'an. Thus, it is concluded that the product of science teaching materials integrated with al-Qur'an verses is appropriate for improving students' religious attitudes in madrasah.
The CCN Family of Proteins: A Critical Approach to the Multi-Modular Structure of the CCN Domains
Authors: Perbal Bernard 
Published: October 2024

The CCN family of proteins is composed of six members (CCN1-CCN6) sharing a tetra-modular organization and a striking conservation of their primary structure. The CCN acronym was originally assigned in 1993 by P. Bork to three newly discovered factors (originally called CTGF, CYR61, and NOV), which he proposed to constitute a new family of proteins on the basis of their common physical features. Six years later, three other proteins (Wisp1-3), sharing the same tetramodular organization, joined the family (figure 1). The HUGO-recognized acronyms for the CCN proteins were officialized in 2018[1].

The CCN family turned out to contain positive and negative regulators of cell proliferation and differentiation, with pro- and anti-tumorigenic activities. A significant amount of work has been performed to identify the participation of the constitutive modules in these biological features. The aim of this review is to briefly examine the potential roles assigned to the constitutive modules of CCN proteins and propose a critical view of the structural basis for their interactions and functions.
Peran TPQ dalam Meningkatkan Kualitas Kemampuan Baca Al-Qur’an pada Anak di TPQ Darul Fallah 2 Japanan Mojowarno Jombang
Authors: Muhtadi Muhtadi , Pahlawati Eny Fatimatuszuhro , Maulida Putri 
Published: October 2024

Penelitian ini bertujuan untuk mengetahui peran TPQ dalam meningkatkan kualitas kemampuan baca Al-Qur’an pada anak di TPQ Darul Fallah 2 Japanan Mojowarno Jombang.
Penelitian ini menggunakan pendekatan deskriptif kualitatif. Pengumpulan datanya menggunakan teknik observasi, wawancara dan dokumentasi dengan teknik analisis deduktif dan induktif.
Hasil penelitian menunjukkan bahwa peran Taman Pendidikan Al-Qur'an (TPQ) Darul Fallah 2 dalam meningkatkan kualitas kemampuan baca Al-Qur'an pada anak sangat signifikan. TPQ Darul Fallah 2 memiliki beberapa elemen kunci yang mendukung keberhasilan proses pembelajaran, antara lain perencanaan yang matang, keberadaan pengajar yang bermukim di satu desa, penyusunan kurikulum yang fleksibel, serta penggunaan metode pembelajaran tilawati yang terstruktur. Selain itu, sarana prasarana yang memadai dan evaluasi pembelajaran yang dilakukan secara berkala juga berperan penting dalam mencapai hasil yang optimal.
Kata kunci : TPQ Darul Fallah 2; Kemampuan Baca Al-Qur’an; Anak
Repurposing of Oxicam Derivatives to Inhibit NDM-1: Molecular Docking and Molecular Dynamic Simulation Studies
Authors: Pshtiwan Gharib Ali  , Twana Mohsin Salih  
Published: October 2024

يسبب New Delhi Metallo-β-lactamase-1 (NDM-1) التحلل المائي للمضادات الحيوية واسعة النطاق من نوع β-lactam، مثل الكاربابينيمات، مما يؤدي إلى تطور مقاومة مضادات الميكروبات. ومع ذلك، لا توجد أي مثبطات NDM-1 معتمدة على مستوى العالم. ولذلك، فإن إعادة وضع الأدوية المعتمدة كمثبطات NDM-1 لتتحد مع الكاربابينيمات قد تكون استراتيجية حاسمة لمكافحة مسببات الأمراض المقاومة. هذه الدراسة تعيد الأغراض.
مشتقات الأوكسيكام كمثبطات للبكتيريا NDM-1. تم الحصول على الهياكل ثنائية الأبعاد من قاعدة بيانات PubChem. تم تقييم عشرين من مشتقات الأوكسيكام حسابيًا لتحقيق قدرتها على تثبيط NDM-1. لتحديد المثبطات المحتملة للبروتين المستهدف NDM-1، تم استخدام بروتوكول الالتحام الجزيئي. بالإضافة إلى ذلك، تم توقع التشابه الدوائي والخصائص الدوائية للجزيئات المصممة. تم اختيار ثلاثة مركبات ذات نتائج ΔGbinding الأكثر سلبية لإجراء دراسة إضافية باستخدام عمليات المحاكاة الديناميكية الجزيئية (MD). تمتلك المركبات M010 وM013 وM016 طاقة ارتباط حرة سلبية أكثر بكثير من التحكم الإيجابي والجزيئات المصممة الأخرى، ولها محاكاة MD مستقرة (انحراف الجذر المتوسط ​​<0.5 Å)، واجتازت قاعدة ليبينسكي الخمسة، وامتلكت مواتية. الخصائص الفيزيائية والكيميائية والحركية الدوائية. يمكن أن تفيد النتائج الدراسات المختبرية للمركبات الواعدة.
Vegetation monitoring in mining area using canopy reflectance and landsat8 oli image
Authors: Wu Pan , Chen Ling , Wang Tao , Wang Kun , Tian Runqing , Fu Quan 
Published: October 2024

The aim of this study is to find out the vegetation monitoring in mining areas which is of great significance in grasping the ecological environment status of mining areas. As the first target of spectral reflection, the vegetation canopy directly affects the results of spectral reception. Leaf Angle Distribution (LAD) is a key canopy structural parameter, which directly determines the amount of solar radiation intercepted by the canopy. Taking the relationship between the effect of leaf inclination angle on vegetation canopy reflectance and NDVI as an entry point, the study monitored and analyzed the vegetation in Dexing mining area, China, from 2013 to 2018 by NDVI, based on which the Copper Stress Vegetation Index (CSVI), which is applicable to the narrow wavelength band of remote sensing imagery, was evaluated whether it could be applied to the wide wavelength band. The results show that the NDVI value of the horizontal distribution is significantly higher than that of other leaf inclination distributions, and the NDVI in the direction of the horizontal distribution is 0.82, while the NDVI in the direction of the hi-straight distribution is 0.75; the NDVI of the mining area decreases gradually with the increase of the area of the mining area, and the correlation coefficients of the two groups of CSVI based on the wide and narrow bands are not large, which is not suitable for the vegetation monitoring by using the Landsat8 OLI imagery. Wide band is less applicable for vegetation monitoring.
Bangladesh J. Bot. 53(3): 835-847, 2024 (September) Special
Development of novel CDK9 and CYP3A4 inhibitors for cancer therapy through field and computational approaches
Authors: Alsfouk Aisha A. , Faris Abdelmoujoud , Cacciatore Ivana , Alnajjar Radwan 
Published: October 2024

Cyclin-dependent kinase 9 (CDK9) and cytochrome P450 3A4 (CYP3A4) have emerged as promising targets in the development of anticancer drugs, presenting a consistent challenge in the quest for potent inhibitors. CDK9 inhibitors can selectively target fast-growing cancer cells by disrupting transcription elongation, which in turn hinders the production of proteins essential for cell cycle progression and survivaŚ. Understanding how CYP3A4 metabolizes specific chemotherapy drugs allows for personalized treatment plans, optimizing drug dosages according to a patient’s metabolic profile. Since many cancer patients undergo combination therapies, and CYP3A4 is vital in drug metabolism, its inhibition or induction by one drug can alter the plasma levels of others, potentially leading to treatment failure or increased toxicity. Therefore, managing CYP3A4 activity is critical for effective cancer treatment. Employing a range of computational methodologies, this study systematically investigated the binding mechanisms of pyrimidine derivatives against CDK9 and CYP3A4. The field-based model demonstrated high R2 values (0.99), with Q2 (0.66), demonstrating its ability to predict in silico inhibitory activity against the target of this study. The screening process followed in this work led to the discovery of powerful new inhibitor compounds. Of the 15 new compounds designed, three have a high affinity with the target (ranging from −8 to −9 kcal/mol kcal/mol) and were singled out through docking filtration for more detailed investigation. As well as, a reference compound with a substantial pIC50 value of 8.4, serving as the foundation for the development of the new compounds, was included for comparative analysis. To elucidate the essential features of CDK9 and CYP3A4 inhibitor design, a comparative analysis was conducted between 3D-QSAR-generated contours and molecular docking conformations of ligands. Molecular dynamics simulations were carried out for a duration of 100 ns on selected docked complexes, specifically those involving novel compounds with CDK9 and CYP3A4 enzymes. Additionally, the binding free energy for these complexes was assessed using the MM/PBSA method, which evaluates the free energy landscape of protein-ligand interactions. The results of MM/PBSA highlighted the strength of the new compounds in enhancing interactions with the target protein, which favors the results of molecular docking and MD simulation. These insights contribute to a deeper understanding of the mechanisms underlying CDK9 and CYP3A4 inhibition, offering potential avenues for the development of innovative and effective CDK9 inhibitors.
Hypertensive disorders of pregnancy and stroke: a univariate and multivariate Mendelian randomization study
Authors: Qu Kang , Li Mingxi , Yu Peng , Jiang Wei , Dong Ming 
Published: October 2024

BackgroundHypertensive disorders of pregnancy (HDP) are associated with an increased risk of stroke later in life in multiparous women. However, causality of these associations remains unclear. This study employed 2-sample univariate and multivariate Mendelian randomization (MR) to assess the causal connection between HDP and stroke.MethodsGenetic variants for HDP and two subtypes were identified from recent large-scale genome-wide association studies and the FinnGen consortium. Stroke summary data were obtained from the MEGASTROKE consortium. The primary analytical approach for univariate MR was the inverse variance weighting method. Sensitivity analyses incorporated methods such as MR-Egger regression, weighted median, and maximum likelihood to ascertain the robustness of the results. Additionally, multivariable MR analyses were conducted to account for potential associative effects of hypertension and type 2 diabetes.ResultsGenetically predicted HDP was associated with a high risk of large artery atherosclerosis (odds ratio [OR]=1.50, 95% confidence interval [CI]: 1.17–1.91, P=1.13×10-3) and small vessel stroke (OR=1.29, 95% CI: 1.20–1.50, P=1.52×10-3). HDP may also correlate with ischemic stroke (OR=1.13, 95% CI: 1.04–1.23, P=4.99×10-3) and stroke (OR=1.11, 95% CI: 1.03–1.20, P=8.85×10-3). An elevated risk of small vessel stroke (OR=1.20, 95% CI: 1.01–1.43, P=3.74×10-2) and large artery atherosclerosis (OR=1.22, 95% CI: 1.01–1.47, P=4.07×10-2) may be related with genetically predicted susceptibility to gestational hypertension. Genetically predicted susceptibility to preeclampsia or eclampsia may be associated with an increased risk of stroke (OR = 1.10, 95% CI: 1.02–1.19, P = 1.16×10-2) and ischemic stroke (OR = 1.10, 95% CI: 1.02–1.20, P = 1.84×10-2). Type 2 diabetes mellitus and hypertension were identified as significant factors contributing to the association between HDP and stroke.ConclusionsThis study provides genetic evidence supporting an association between HDP and increased stroke risk bolstering HDP as a cerebrovascular risk factor.
Genetic heterogeneity in autosomal recessive hearing loss: a survey of Brazilian families
Authors: Antunes Larissa Nascimento , Dias Alex Marcel Moreira , Schiavo Beatriz Cetalle , Mendes Beatriz C. A. , Bertola Debora Romeo , Lezirovitz Karina , Mingroni-Netto Regina Célia 
Published: October 2024

IntroductionHearing loss is a frequent sensory impairment type in humans, with about 50% of prelingual cases being attributed to genetic factors. Autosomal recessive hearing loss (ARHL) exhibits great locus heterogeneity and is responsible for 70%–80% of hereditary nonsyndromic cases.MethodsA total of 90 unrelated Brazilian individuals were selected for having hearing loss of presumably autosomal recessive inheritance, either born from consanguineous marriages or belonging to families with two or more affected individuals in the sibship and most cases were of normal hearing parents. In all cases, common pathogenic variants in GJB2 (c.35delG), GJB6 [del(GJB6-D13S1830) and del(GJB6-D13S1854)] and MT-RNR1 (m.1555A&gt;G) were discarded and most were previously assessed by complete Sanger sequencing of GJB2. Their genetic material was analyzed through next-generation sequencing, targeting 99 hearing loss-related genes and/or whole exome sequencing.ResultsIn 32 of the 90 probands (36,7%) causative variants were identified, with autosomal recessive inheritance confirmed in all, except for two cases due to dominant variants (SIX1 and P2RX2). Thirty-nine different causative variants were found in 24 different known hearing loss-associated genes, among which 10 variants are novel, indicating wide genetic heterogeneity in the sample, after exclusion of common pathogenic variants. Despite the genetic heterogeneity, some genes showed greater contribution: GJB2, CDH23, MYO15A, OTOF, and USH2A.ConclusionThe present results confirmed that next-generation sequencing is an effective tool for identifying causative variants in autosomal recessive hearing loss. To our knowledge, this is the first report of next-generation sequencing being applied to a large cohort of pedigrees with presumable autosomal recessive hearing loss in Brazil and South America.
The effect of 12-week high-dose Colostrum Bovinum supplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study
Authors: Durkalec-Michalski Krzysztof , Główka Natalia , Podgórski Tomasz , Woźniewicz Małgorzata , Nowaczyk Paulina M. 
Published: October 2024

BackgroundBovine colostrum (COL) is assumed to be one of the strongest natural immune stimulants. Regular ingestion of COL may contribute to improved immune response in athletes exposed to high training loads.MethodsTwenty-eight endurance-trained males aged 31.1 ± 10.2 years (body mass 81.9 ± 9.0 kg; height 1.82 ± 0.06 m) completed this randomized double-blind placebo(PLA)-controlled crossover study aimed at investigating the effect of 12-week COL supplementation (25gCOL·day-1) on resting (REST), exercise-induced (POST-EX), and short-term post-exercise recovery (REC; 1 h after test exercise) changes in selected saliva and blood immunoglobulins (Ig), white blood cell (WBC) count and differential; as well as blood hematological, nutritional status and muscle damage indices. The protocol assumed 4 study visits – before/after supplementation with COL (COLPRE and COLPOST) and PLA (PLAPRE and PLAPOST). During testing sessions, incremental rowing test to exhaustion and swimming-specific performance test were introduced as exercise stimuli.ResultsAt COLPOST visit the secretory IgA (SIgA) concentration in saliva was significantly higher at POST-EX and REC compared to REST (p&lt;0.05). COL supplementation had no effect on blood IgA, IgE, IgD, IgG, and IgM concentrations. Furthermore, after COL supplementation decrease of hematocrit at REC (p&lt;0.05) was revealed.Conclusions12-week supplementation with 25 gCOL·day-1 in endurance-trained male athletes resulted in a favorable increase in post-exercise concentration of salivary SIgA. COL seems to be a potential stimulator of local immune defense after exercise-induced homeostasis disturbances. Nevertheless, the lack of effect on blood markers indicates the need for further research in the area of mechanisms underlying the effect of the supposed COL immunological capacity.
Cytokine production in an ex vivo model of SARS-CoV-2 lung infection
Authors: Vorobyeva Daria A. , Potashnikova Daria M. , Maryukhnich Elena V. , Rusakovich George I. , Tvorogova Anna V. , Kalinskaya Anna I. , Pinegina Natalia V. , Kovyrshina Anna V. , Dolzhikova Inna V. , Postnikov Alexander B. , Rozov Fedor N. , Sotnikova Tatiana N. , Kanner Dmitry Yu. , Logunov Denis Yu. , Gintsburg Alexander L. , Vasilieva Elena J. , Margolis Leonid B. 
Published: October 2024

IntroductionThe mechanisms of the SARS-CoV-2-triggered complex alterations in immune cell activation and production of cytokines in lung tissue remain poorly understood, in part because of the limited use of adequate tissue models that simulate the structure and cell composition of the lung in vivo. We developed a novel ex vivo model of SARS-CoV-2 infection of lung explants, that maintains the intact tissue composition and the viral load for up to 7–10 days. Using this model, we studied cytokine production during SARS-CoV-2 infection.Materials and methodsLung tissue was monitored for viability and cell composition using flow cytometry and histological analysis. SARS-CoV-2 infection was verified immunohistochemically, viral loads in tissue and culture medium were monitored by qPCR. A panel of 41 cytokines was measured in culture medium using xMAP technology.ResultsThe explant lung tissue was viable and maintained viral infection that influenced the cytokine production. Elevated concentrations of G-CSF, GM-CSF, GRO-a, IFN-g, IL-6, IL-8, IP-10, MCP-3, MIP-1a, PDGF-AA, and VEGF, and decreased IL-1RA concentration were observed in infected tissue compared to non-infected tissue.DiscussionOur results generally reflect the data obtained in COVID-19 patients. GRO-a, IFN-g, IL-6, IL-8, MCP-1, MCP-3, and RANTES correlated with the viral load, forming a distinct pro-inflammatory cluster. Thus, our lung ex vivo model faithfully reproduces some aspects of cytokine alterations in COVID-19 patients at an early disease stage, making the investigation of SARS-CoV-2 infection mechanisms more accessible and providing a potential platform for antiviral drug testing.