bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population
Authors: Chen Si , Wen Xiaoting , Li Liubing , Li Jing , Li Yuan , Wang Qian , Yuan Hui , Zhang Fengchun , Li Yongzhe 
Published: October 2017

AbstractSingle-nucleotide polymorphisms (SNPs) in the ETS1 gene are associated with several auto-inflammatory diseases. In this study, we determined whether ETS1 gene polymorphisms confer susceptibility to idiopathic inflammatory myopathies (IIMs) in a northern Chinese Han population. DNA samples were collected from 1017 IIM patients: 363 PM cases and 654 DM cases. The results were compared with those of 1280 healthy controls. Five SNPs in the ETS1 region (rs7117932, rs6590330, rs4937362, rs10893845 and rs1128334) were assessed and genotyped using the Sequenom platform. Our data indicated that the rs7117932 alleles and genotypes are associated with DM and IIMs (P
c
= 6.0 × 10−3 and P
c
= 0.029; P
c
= 0.013 and P
c
= 0.019, respectively). We found a significantly greater percentage of DM and IIM patients with an A allele of rs6590330 than that in the control population (P
c
= 0.033 and P
c
= 0.013). Additionally, the rs6590330 genotype was associated with IIMs (P
c
= 0.020). The percentages of rs7117932 and rs6590330 SNPs were significantly greater in DM and IIM patients with interstitial lung disease (ILD) (all P
c
< 0.05). This is the first study to reveal that ETS1 polymorphisms are associated with IIMs alone and IIMs with ILD in a northern Chinese Han population.
Experimental demonstration of magnetoplasmon polariton at InSb(InAs)/dielectric interface for terahertz sensor application
Authors: Chochol Jan , Postava Kamil , Čada Michael , Pištora Jaromír 
Published: October 2017

AbstractWe experimentally demonstrate surface plasmon resonance (SPR) in the terahertz range in InSb and InAs. The surface plasmon is excited on the interface between a thin polymer film and the semiconductor using a silicon prism in Otto configuration. The low effective mass of InSb and InAs permits tuning of the SPR by an external magnetic field in the transversal configuration. The data show a good agreement with a model. Strong excitation of the surface plasmon is present in both materials, with a shifting of resonance position by more than 100 GHz for the field of 0.25 T, to both higher and lower energies with opposite orientation of the magnetic field. Applicability of the terahertz SPR sensor is discussed, along with modeled design for the Kretschmann configuration.
Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats
Authors: Anzai Álvaro , Marcondes Rodrigo R. , Gonçalves Thiago H. , Carvalho Kátia C. , Simões Manuel J. , Garcia Natália , Soares José M. , Padmanabhan Vasantha , Baracat Edmund C. , da Silva Ismael D. C. G. , Maciel Gustavo A. R. 
Published: October 2017

AbstractPolycystic ovary syndrome (PCOS) is frequently associated with non-alcoholic fatty liver disease (NAFLD), but the mechanisms involved in the development of NAFLD in PCOS are not well known. We investigated histological changes and metabolomic profile in the liver of rat models of PCOS phenotype induced by testosterone or estradiol. Two-day old female rats received sc injections of 1.25 mg testosterone propionate (Testos; n = 10), 0.5 mg estradiol benzoate (E2; n = 10), or vehicle (control group, CNT; n = 10). Animals were euthanized at 90–94 d of age and the liver was harvested for histological and metabolomic analyses. Findings showed only Testos group exhibited fatty liver morphology and higher levels of ketogenic and branched-chain amino acids (BCAA). Enrichment analysis showed effects of testosterone on BCAA degradation pathway and mitochondrial enzymes related to BCAA metabolism. Testos group also had a decreased liver fatty acid elongase 2 (ELOVL2) activity. E2 group had reduced lipid and acylcarnitine metabolites in the liver. Both groups had increased organic cation transporters (SLC22A4 and SLC16A9) activity. These findings indicate that neonatal testosterone treatment, but not estradiol, produces histological changes in female rat liver that mimic NAFLD with testosterone-treated rats showing impaired BCAA metabolism and dysfunctions in ELOVL2, SLC22A4 and SLC16A9 activity.
Insights into grapevine defense response against drought as revealed by biochemical, physiological and RNA-Seq analysis
Authors: Haider Muhammad Salman , Zhang Cheng , Kurjogi Mahantesh M. , Pervaiz Tariq , Zheng Ting , Zhang Chaobo , Lide Chen , Shangguan Lingfie , Fang Jinggui 
Published: October 2017

AbstractGrapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plants. Results generated 12,451 differentially expressed genes (DEGs), out of which 8,021 genes were up-regulated, and 4,430 were down-regulated. Further physiological and biochemical investigations were also performed to validate the biological processes associated with the development of grapevine in response to drought stress. Results also revealed that decline in the rate of stomatal conductance, in turn, decrease the photosynthetic activity and CO2 assimilation in the grapevine leaves. Reactive oxygen species, including stress enzymes and their related proteins, and secondary metabolites were also activated in the present study. Likewise, various hormones also induced in response to drought stress. Overall, the present study concludes that these DEGs play both positive and negative roles in drought tolerance by regulating various biological pathways of grapevine. Nevertheless, our findings have provided valuable gene information for future studies of abiotic stress in grapevine and various other fruit crops.
Angiotensin-converting enzyme Ance is cooperatively regulated by Mad and Pannier in Drosophila imaginal discs
Authors: Kim Ah-Ram , Choi Eun-Bee , Kim Mi-Young , Choi Kwang-Wook 
Published: October 2017

AbstractAngiotensin-converting enzyme (ACE) is an evolutionarily conserved peptidyl dipeptidase. Mammalian ACE converts angiotensin I to the active vasoconstrictor angiotensin II, thus playing a critical role for homeostasis of the renin-angiotensin system. In Drosophila, the ACE homolog Ance is expressed in specific regions of developing organs, but its regulatory mechanism has not been identified. Here we provide evidence that Ance expression is regulated by a combination of Mad and Pannier (Pnr) in imaginal discs. We demonstrate that Ance expression in eye and wing discs depends on Dpp signaling. The Mad binding site of Ance regulatory region is essential for Ance expression. Ance expression in imaginal discs is also regulated by the GATA family transcription factor Pnr. Pnr directly regulates Ance expression by binding to a GATA site of Ance enhancer. In addition, Pnr and Mad physically and genetically interact. Ance null mutants are morphologically normal but show genetic interaction with dpp mutants. Furthermore, we show that human SMAD2 and GATA4 physically interact and ACE expression in HEK293 cells is regulated by SMAD2 and GATA4. Taken together, this study reveals a cooperative mechanism of Ance regulation by Mad and Pnr. Our data also suggest a conserved transcriptional regulation of human ACE.
Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface
Authors: Flowers Sarah A. , Zieba Agata , Örnros Jessica , Jin Chunsheng , Rolfson Ola , Björkman Lena I. , Eisler Thomas , Kalamajski Sebastian , Kamali-Moghaddam Masood , Karlsson Niclas G. 
Published: October 2017

AbstractLubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis. This investigation was undertaken to localise COMP-lubricin complexes within cartilage and investigate if other cartilage proteins are involved in anchoring lubricin to the joint. Immunohistochemical analysis of human cartilage biopsies showed lubricin and COMP co-localise to the cartilage surface. COMP knockout mice, however, presented with a lubricin layer on the articular cartilage leading to the further investigation of additional lubricin binding mechanisms. Proximity ligation assays (PLA) on human cartilage biopsies was used to localise additional lubricin binding partners and demonstrated that lubricin bound COMP, but also fibronectin and collagen II on the cartilage surface. Fibronectin and collagen II binding to lubricin was confirmed and characterised by solid phase binding assays with recombinant lubricin fragments. Overall, COMP, fibronectin and collagen II bind lubricin, exposed on the articular cartilage surface suggesting they may be involved in maintaining essential boundary lubrication.
Sandwich-structured C/C-SiC composites fabricated by electromagnetic-coupling chemical vapor infiltration
Authors: Hu Chenglong , Hong Wenhu , Xu Xiaojing , Tang Sufang , Du Shanyi , Cheng Hui-Ming 
Published: October 2017

AbstractCarbon fiber (CF) reinforced carbon-silicon carbide (C/C-SiC) composites are one of the most promising lightweight materials for re-entry thermal protection, rocket nozzles and brake discs applications. In this paper, a novel sandwich-structured C/C-SiC composite, containing two exterior C/SiC layers, two gradient C/C-SiC layers and a C/C core, has been designed and fabricated by two-step electromagnetic-coupling chemical vapor infiltration (E-CVI) for a 20-hour deposition time. The cross-section morphologies, interface microstructures and SiC-matrix growth characteristics and compositions of the composites were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD), respectively. Microstructure characterization indicates that the SiC growth includes an initial amorphous SiC zone, a gradual crystallization of SiC and grow-up of nano-crystal, and a columnar grain region. The sandwich structure, rapid deposition rate and growth characteristics are attributed to the formation of thermal gradient and the establishment of electromagnetic field in the E-CVI process. The composite possesses low density of 1.84 g/cm3, high flexural strength of 325 MPa, and low linear ablation rate of 0.38 μm/s under exposure to 5-cycle oxyacetylene flame for 1000 s at ~1700 °C.
Rare occurrence of inflammatory bowel disease in a cohort of Han Chinese ankylosing spondylitis patients- a single institute study
Authors: Wang Chrong-Reen , Weng Chia-Tse , Lee Chung-Ta , Huang Kuo-Yuan , Hsu Sheng-Min , Liu Ming-Fei 
Published: October 2017

AbstractDespite a high prevalence of ankylosing spondylitis (AS) in Han Chinese, the clinical experience remains very limited in the extra-articular presentation of inflammatory bowel disease (IBD). A monocentric retrospective study was performed for the AS-associated IBD manifestation. This study analyzed AS patients fulfilling the 1984 revised New York diagnostic criteria, excluding those who had the onset of IBD before or concurrently with the diagnosis of AS, for their demographic, clinical, laboratory, radiological, pathological and medication data, particularly in the usage of anti-TNF monoclonal antibody. Among 988 AS patients with 19.8% female, 4 (0.4%) had the overt IBD presentation, one female and 3 male aged 28 to 47 years (38.8 ± 4.6), all ulcerative colitis with the characteristic histopathological findings. At the onset of colitis, all had a long-term disease duration of 10 to 25 years (17.5 ± 6.5) and high BASDAI 7.5 to 8.8 (8.2 ± 0.5) with the hip joint involvement. There were recurrent flares of colitis despite the treatment with corticosteroids and messalazopyrin/salazopyrin, and no relapses of IBD were observed for 6.0 ± 1.1 years after the adalimumab (ADA) therapy. In this retrospective cohort, we demonstrate the rarity of AS-associated IBD manifestation in Han Chinese with a beneficent effect from the ADA therapy.
Correlation between the Arrhenius crossover and the glass forming ability in metallic glasses
Authors: Wen Tongqi , Yao Wenjing , Wang Nan 
Published: October 2017

AbstractThe distinctive characteristic of the metallic glass-forming system is that the variation in viscosity with temperature obeys Vogel-Fulcher-Tammann (VFT) relationship in the undercooled state and Arrhenius relationship in the high temperature region. A dimensionless index has thus been proposed based on the Arrhenius-VFT crossover and the classical nucleation rate and growth rate theory to evaluate the glass-forming ability (GFA). The indicator G(a) is expressed with the combination of T
g
, the glass transition temperature, T
x
, the onset crystallization temperature, T
l
, the liquidus temperature, T0, the VFT temperature, and a a constant that could be determined according to the best correlation between G(a) and the critical cooling rate (R
c
). Compared with other GFA indexes, G(a) shows the best fit with R
c
, with the square of the correlation coefficient (R2) being 0.9238 when a = 0.15 for the 23 various alloy systems concerned about. Our results indicate the crossover in the viscosity variation has key effect on GFA and one can use the index G(a) to predict R
c
and GFA for different alloys effectively.
Enhanced terahertz fingerprint detection with ultrahigh sensitivity using the cavity defect modes
Authors: Shi Xiaomei , Han Zhanghua 
Published: October 2017

AbstractWe report a new scheme of realizing terahertz fingerprint detection with ultrahigh sensitivity. Instead of using the direct absorption of terahertz through a bare sample in the regular transmission scheme, a cavity mode resonating at the characteristic frequency of the sample is used and due to the high dependence of the cavity mode transmission on the material loss, an amplified transmission decaying is observed when the sample is loaded into the cavity. Furthermore, this scheme retains the feature of substance identification. A one-dimensional photonic crystal cavity is used as the example for the detection of α-lactose and an efficient detection of 10 nm α-lactose can be achieved, which corresponds to 1/57000 of the free space wavelength at the characteristic frequency of 0.529 THz, exhibiting a sensitivity over 400 times higher than the regular transmission method.
Pharmacological HIF-inhibition attenuates postoperative adhesion formation
Authors: Strowitzki Moritz J. , Ritter Alina S. , Radhakrishnan Praveen , Harnoss Jonathan M. , Opitz Vanessa M. , Biller Marvin , Wehrmann Julian , Keppler Ulrich , Scheer Jana , Wallwiener Markus , Schmidt Thomas , Ulrich Alexis , Schneider Martin 
Published: October 2017

AbstractPeritoneal adhesions represent a common complication of abdominal surgery, and tissue hypoxia is a main determinant in adhesion formation. Reliable therapeutic options to reduce peritoneal adhesions are scarce. We investigated whether the formation of postsurgical adhesions can be affected by pharmacological interference with hypoxia-inducible factors (HIFs). Mice were treated with a small molecule HIF-inhibitor, YC-1 (3-[5′-Hydroxymethyl-2′-furyl]-1-benzyl-indazole), or vehicle three days before and seven days after induction of peritoneal adhesions or, alternatively, once during induction of peritoneal adhesions. Pretreatment or single intraperitoneal lavage with YC-1 significantly reduced postoperative adhesion formation without prompting systemic adverse effects. Expression analyses of cytokines in peritoneal tissue and fluid and in vitro assays applying macrophages and peritoneal fibroblasts indicated that this effect was cooperatively mediated by various putatively HIF-1α-dependent mechanisms, comprising attenuated pro-inflammatory activation of macrophages, impaired recruitment and activation of peritoneal fibroblasts, mitigated epithelial-mesenchymal-transition (EMT), as well as enhanced fibrinolysis and impaired angiogenesis. Thus, this study identifies prevention of postsurgical peritoneal adhesions as a novel and promising field for the application of HIF inhibitors in clinical practice.
The best platinum regimens for chemo-naive incurable non-small cell lung cancer: network meta-analysis
Authors: Horita Nobuyuki , Nagashima Akimichi , Nakashima Kentaro , Shibata Yuji , Ito Kentaro , Goto Atsushi , Yamanaka Takeharu , Kaneko Takeshi 
Published: October 2017

AbstractPlatinum regimens still play a key role in chemotherapy for incurable non-small cell lung cancer (NSCLC). Although guidelines list many platina regimens, the best regimens have not yet clarified. Electronic searches were carried out during November 26th-28th, 2016. We included individually randomized trials comparing two or more platinum regimes for incurable chemo-naive NSCLC published in English full papers. The platinum doublets should be either Cisplatin (CDDP), Carboplatin (CBDCA), or Nedaplatin (CDGP) plus one of the third-generation agents. The platinum triplet should be the doublet plus bevacizumab (BEV). The data were independently extracted and cross-checked by two investigators. We did not observed heterogeneity (whole network level Q = 28.9, df = 34, P = 0.717) among 59 pairwise comparisons from 45 studies with 16141 cases for the primary outcome, hazard ratio for overall survival (HRos). Using CBDCA + Paclitaxel (PTX) + BEV as a common comparator, CDGP + Docetaxel (DTX) (HRos = 0.98, 95%CI: 0.75–1.29, P = 0.884), CDDP + Tegafur gimeracil oteracil (S1) (HRos = 1.23, 95%CI: 0.96–1.57, P = 0.099), CBDCA + S1 (HRos = 1.23, 95%CI: 0.99–1.53, P = 0.062), and CDGP + Gemcitabine (GEM) (HRos = 1.24, 95%CI: 0.71–2.17, P = 0.45) did not have significantly poorer HRos. We suggest that these regimens as acceptable first-choice regimens.
Conjugation with L,L-diphenylalanine Self-Assemblies Enhances In Vitro Antitumor Activity of Phthalocyanine Photosensitizer
Authors: Souza Márcia I. , Prieto Tatiana , Rodrigues Tiago , Ferreira Fabio F. , Nascimento Francisco B. , Ribeiro Anderson O. , Silva Emerson R. , Giuntini Francesca , Alves Wendel A. 
Published: October 2017

AbstractWe present the synthesis and characterization of new peptide conjugates obtained by hierarchical co-assembly of L,L-diphenylalanine (FF) and zinc phthalocyanine complexes (ZnPc) in water. Self-assembly capabilities under defined conditions were investigated by scanning electron microscopy, and photophysical properties were evaluated using UV-Vis and fluorescence spectroscopy. AFM observations demonstrated that these ZnPcs form different highly ordered arrays on the crystalline faces of the FF microplates and that surface roughness significantly changes with the presence of differently substituted phthalocyanine units. XRD assays showed that the overall molecular packing of the conjugates is organized according to a hexagonal symmetry, with ZnPcs hosted in the interstices of the peptide phase. In vitro photodynamic studies were conducted on human breast cancer MCF-7 cells to investigate both cellular uptake and cytotoxicity. It was shown that FF self-assemblies are not toxicity and enhance accumulation of ZnPc in MCF-7 cells, improving apoptotic cell death upon irradiation. Our findings demonstrate enhancement of ZnPc antitumor efficiency by FF conjugates and a proof-of-concept for new photosensitizer carriers based on peptide conjugates.
A study of dust properties in the inner sub-au region of the Herbig Ae star HD 169142 with VLTI/PIONIER
Authors: Chen L. , Kóspál Á. , Ábrahám P. , Kreplin A. , Matter A. , Weigelt G. 
Published: October 2017

Context. An essential step to understanding protoplanetary evolution is the study of disks that contain gaps or inner holes. The pre-transitional disk around the Herbig star HD 169142 exhibits multi-gap disk structure, differentiated gas and dust distribution, planet candidates, and near-infrared fading in the past decades, which make it a valuable target for a case study of disk evolution.
Aims. Using near-infrared interferometric observations with VLTI/PIONIER, we aim to study the dust properties in the inner sub-au region of the disk in the years 2011−2013, when the object is already in its near-infrared faint state.
Methods. We first performed simple geometric modeling to characterize the size and shape of the NIR-emitting region. We then performed Monte-Carlo radiative transfer simulations on grids of models and compared the model predictions with the interferometric and photometric observations.
Results. We find that the observations are consistent with optically thin gray dust lying at Rin ~ 0.07 au, passively heated to T ~ 1500 K. Models with sub-micron optically thin dust are excluded because such dust will be heated to much higher temperatures at similar distance. The observations can also be reproduced with a model consisting of optically thick dust at Rin ~ 0.06 au, but this model is plausible only if refractory dust species enduring ~ 2400 K exist in the inner disk.
Update on Pediatric Hip Imaging
Authors: Vanhoenacker Filip , Jaremko Jacob , Jans Lennart , Herregods Nele 
Published: October 2017

AbstractHip disorders are common in children. Prompt diagnosis and treatment are important because of the potential complications. Symptoms are frequently nonspecific, and clinical examination can be difficult and unreliable, especially in smaller children. Therefore, imaging can be valuable. Radiography and ultrasound remain the initial imaging modalities of choice. Increasingly, magnetic resonance imaging is obtained for assessing the pediatric hip, although the long imaging time and need for sedation may limit its use in daily practice. Because of the exposure to ionizing radiation, the use of computed tomography and bone scintigraphy in children is limited to selected cases. Pediatric hip pathology varies depending on patient age. This article provides an overview of common hip pathologies in children including congenital and developmental pathologies, trauma, infectious processes, inflammatory disease, and neoplasm. The age of the child, history, and clinical examination are essential to narrow down the differential diagnosis and subsequent selection of the appropriate imaging modality.
Advanced MR Imaging after Total Hip Arthroplasty: The Clinical Impact
Authors: Khodarahmi Iman , Fritz Jan 
Published: October 2017

AbstractRecent metal artifact reduction techniques in magnetic resonance imaging (MRI) have sparked a new aera in visualization of the peri-implant region and assessment of failing orthopaedic hardware. Modes of failure after total hip arthroplasty can be classified into four broad categories: osseous abnormalities, implant instability and dislocation, implant-associated synovitis, and soft tissue abnormalities. Although MRI is complementary to plain radiography and computed tomography to diagnose the first two categories, it is paramount to investigate the complications related to the synovium and soft tissues. We review the most common modes of failure of hip implants and the MRI characteristics of various causes of pain and dysfunction after hip arthroplasty including osseous stress reaction and fracture, implant loosening, implant instability, polyethylene wear–induced synovitis, adverse reaction to metal debris, infection, hematoma, recurrent hemarthrosis, heterotopic ossification, muscle, tendon, and nerve abnormalities, and periprosthetic neoplasms.