bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative blood loss in total hip and knee arthroplasty: Outcomes associated with intravenous tranexamic acid use in an academic medical center
Authors: Hogan Craig A , Golightly Larry K , Phong Suzanne , Dayton Michael R , Lyda Clark , Barber Gerard R 
Published: March 2016

Objectives: Clinical trials have reported decreased blood loss with the use of tranexamic acid during joint reconstruction. The purpose of this study was to assess the individual practice implications of tranexamic acid use in joint replacement surgery. Methods: Health records of adults undergoing total knee arthroplasty and total hip arthroplasty over a 12-month period were retrospectively reviewed. The treatment group comprised patients who received intravenous tranexamic acid perioperatively. The control group comprised patients who did not receive tranexamic acid. Results: Patients in the treatment group (n = 64) and the control group (n = 99) were well matched for demographics, orthopedic diagnosis, and comorbidities. In-hospital postsurgical mean decreases in hemoglobin concentrations were −4.05 g/dL and −4.94 g/dL in the treatment and control groups, respectively (p < 0.001). Postsurgical mean decreases in hematocrit levels were −11.2% and −14.2% in the treatment and control groups, respectively (p < 0.001). Three patients in the treatment group (5%) and 21 patients in the control group (21%) received red blood cell transfusions (p = 0.006). As compared to control, the relative risk of transfusion in the treatment group was 0.23 (95% confidence interval = 0.07–0.76) and the number needed to treat to avoid one transfusion was 7.0 (95% confidence interval = 3.8–14.4). No evidence of thromboembolism or other serious complications were observed in either group. Conclusions: In patients undergoing joint replacement surgery, perioperative administration of tranexamic acid was associated with diminished blood loss and lesser resource utilization.
Effects of medication adherence on hospitalizations and healthcare costs in patients with schizophrenia in Thailand
Authors: Dilokthornsakul Piyameth , Thoopputra Thitaporn , Patanaprateep Oraluck , Kongsakon Ronnachai , Chaiyakunapruk Nathorn 
Published: March 2016

Background: This study was conducted to determine the impacts of medication adherence on hospitalization and direct healthcare cost in patients with schizophrenia in Thailand. Methods: A retrospective study was undertaken. Patients with schizophrenia aged 18–65 years who visited a University hospital and received antipsychotics from April 2011 to October 2011 were included. Propensity score–adjusted logistic regression was used to determine the impacts of medication adherence on schizophrenia-related and all-cause hospitalizations. Results: A total of 582 patients were included. Three out of 224 patients (1.3%) were hospitalized with schizophrenia in optimal adherence group, while 10 of 140 (7.1%) were hospitalized in under-adherence group, and 7 of 218 (3.2%) were hospitalized in over-adherence group. Based on propensity score–adjusted multivariate logistic regression, the adjusted odds ratio was 5.86 (95% confidence interval = 1.53–22.50) for schizophrenia-related hospitalization and 8.04 (95% confidence interval = 2.20–29.40) for all-cause hospitalization. The average annual direct healthcare costs in patients with optimal adherence, under-adherence, and over-adherence were US$371 ± US$836, US$386 ± US$734, and US$508 ± US$2168, respectively. Conclusion: An initiation of interventions to maintain optimal adherence in patients with schizophrenia would significantly impact the healthcare system.
Clinical Outcomes of High Tibial Osteotomy for Knee Instability
Authors: Dean Chase S. , Liechti Daniel J. , Chahla Jorge , Moatshe Gilbert , LaPrade Robert F. 
Published: March 2016

Background: In recent years there has been an increasing interest in high tibial osteotomy (HTO) to treat patients with chronic knee instability due to posterolateral corner (PLC), posterior cruciate ligament (PCL), and anterior cruciate ligament (ACL) insufficiencies with concurrent malalignment in the coronal and/or sagittal plane. Purpose: To perform a systematic review of the use of HTO for the treatment of knee ligament instability with concurrent malalignment. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of the literature was conducted for the treatment of combined knee ligament instability and malalignment with HTO using the Cochrane Central Register of Controlled Trials, PubMed, and MEDLINE (1980 to present); the queries were performed in July 2015. Terms searched included the following: high or proximal tibial osteotomy, unstable, instability, laxity, subluxation, tibial slope, and malalignment, in the knee joint. Inclusion criteria were as follows: HTO to treat instability of the knee joint in the sagittal and/or coronal plane, minimum 2-year follow-up with reported outcomes measures, English language, and human studies. Animal, basic science, and cadaveric studies were excluded as well as editorials, reviews, expert opinions, surveys, special topics, letters to the editor, and correspondence. Results: The search resulted in 460 studies. After applying exclusion criteria and removing duplicates, 13 studies were considered. Of the studies reviewed, knee ligament pathologies, previous surgeries, and measurement of knee stability were heterogeneous. However, all studies reported an improvement in knee stability after HTO. Most studies reported improvement in outcome scores. However, other studies did not provide preoperative scores for comparison. Reported complication rates ranged from 0% to 47%. Conclusion: Although HTO has been highly advocated and used in treating patients with ligamentous knee instability, there remains a paucity of high-quality studies. Included studies report improvement of instability as well as relatively high patient satisfaction and rate of return to sports. The heterogeneity of the pathology treated, follow-up time, and outcome measures limit comparison between studies.
Resting pulmonary artery pressure of 21–24 mmHg predicts abnormal exercise haemodynamics
Authors: Lau Edmund M.T. , Godinas Laurent , Sitbon Olivier , Montani David , Savale Laurent , Jaïs Xavier , Lador Frederic , Gunther Sven , Celermajer David S. , Simonneau Gérald , Humbert Marc , Chemla Denis , Herve Philippe 
Published: March 2016

A resting mean pulmonary artery pressure (mPAP) of 21–24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21–24 mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise.Consecutive patients (n=290) with resting mPAP <25 mmHg who underwent invasive exercise haemodynamics were analysed. Risk factors for pulmonary vascular disease or left heart disease were present in 63.4% and 43.8% of subjects. An abnormal pulmonary vascular response (or exercise PH) was defined by mPAP >30 mmHg and total pulmonary vascular resistance >3 WU at maximal exercise.Exercise PH occurred in 74 (86.0%) out of 86versus96 (47.1%) out of 204 in the mPAP of 21–24 mmHg and mPAP <21 mmHg groups, respectively (OR 6.9, 95% CI: 3.6–13.6; p<0.0001). Patients with mPAP of 21–24 mmHg had lower 6-min walk distance (p=0.002) and higher New York Heart Association functional class status (p=0.03). Decreasing levels of mPAP were associated with a lower prevalence of exercise PH, which occurred in 60.3%, 38.7% and 7.7% of patients with mPAP of 17–20, 13–16 and <13 mmHg, respectively.In an at-risk population, a resting mPAP between 21–24 mmHg is closely associated with exercise PH together with worse functional capacity.
Fixed point theorems of order-Lipschitz mappings in Banach algebras
Authors: Jiang Shujun , Li Zhilong 
Published: March 2016

AbstractIn this paper, by introducing the concept of Picard-completeness and using the sandwich theorem in the sense of w-convergence, we first prove some fixed point theorems of order-Lipschitz mappings in Banach algebras with non-normal cones which improve the result of Sun’s since the normality of the cone was removed. Moreover, we reconsider the case with normal cones and obtain a fixed point theorem under the assumption relating to the spectral radius, which partially improves the results of Krasnoselskii and Zabreiko’s. In addition, we present some suitable examples which show the usability of our theorems.
Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation
Authors: Jhunjhunwala Siddharth , Alvarez David , Aresta-DaSilva Stephanie , Tang Katherine , Tang Benjamin C , Greiner Dale L , Newburger Peter E , von Andrian Ulrich H , Langer Robert , Anderson Daniel G 
Published: March 2016

Abstract
Neutrophils are constantly generated from hematopoietic stem and progenitor cells in the bone marrow to maintain high numbers in circulation. A considerable number of neutrophils and their progenitors have been shown to be present in the spleen too; however, their exact role in this organ remains unclear. Herein, we sought to study the function of splenic neutrophils and their progenitors using a mouse model for sterile, peritoneal inflammation. In this microcapsule device implantation model, we show chronic neutrophil presence at implant sites, with recruitment from circulation as the primary mechanism for their prevalence in the peritoneal exudate. Furthermore, we demonstrate that progenitor populations in the spleen play a key role in maintaining elevated neutrophil numbers. Our results provide new insight into the role for splenic neutrophils and their progenitors and establish a model to study neutrophil function during sterile inflammation.
The effect of second-generation antipsychotics on hippocampal volume in first episode of psychosis: longitudinal study
Authors: Bodnar Michael , Malla Ashok K. , Makowski Carolina , Chakravarty M. Mallar , Joober Ridha , Lepage Martin 
Published: March 2016

BackgroundCurrent neuroscience literature has related treatment with aripiprazole to improved memory performance and subcellular changes in the hippocampus.AimsTo explore the volumetric changes in hippocampal grey matter in people with a first episode of psychosis (FEP) treated with second-generation antipsychotics.MethodBaseline and 1-year follow-up magnetic resonance images were obtained. Hippocampal volumes were estimated by using FreeSurfer and MAGeT-Brain. Subgroups included: aripiprazole (n=13), olanzapine (n=12), risperidone/paliperidone (n=24), refused-antipsychotics (n=13) and controls (n=44).ResultsAripiprazole subgroup displayed significant increases in bilateral hippocampal volume compared with all other subgroups (FreeSurfer: all P's<0.012; MAGeT-Brain: all P's<0.040).ConclusionsAripiprazole is a first-line, second-generation treatment option that may provide an added benefit of pro-hippocampal growth. The biological underpinnings of these changes should be the focus of future investigations and may be key towards achieving a better clinical outcome for more individuals.
Mental capacity to consent to treatment in anorexia nervosa: explorative study
Authors: Elzakkers Isis F.F.M. , Danner Unna N. , Hoek Hans W. , van Elburg Annemarie A 
Published: March 2016

BackgroundMental capacity to consent to treatment in anorexia nervosa is a neglected area in clinical decision-making.AimsTo examine clinical and neuropsychological parameters associated with diminished mental capacity in anorexia nervosa.MethodAn explorative study was conducted in 70 adult female patients with severe anorexia nervosa. Mental capacity to consent to treatment was assessed by experienced psychiatrists. Further measurements included the MacCAT-T (to assess mental capacity status), a range of clinical measures (body mass index (BMI) and comorbidity) and neuropsychological tests assessing decision-making, central coherence and set-shifting capacity.ResultsDiminished mental capacity occurs in a third of patients with severe anorexia nervosa and is associated with a low BMI, less appreciation of illness and treatment, previous treatment for anorexia nervosa, low social functioning and poor set shifting.ConclusionsAssessment of diminished mental capacity in anorexia nervosa requires careful evaluation of not only BMI, but also the degree of appreciation of illness and treatment, history and the tendency to have a rigid thinking style.
Serum Amino Acid Profiles in Childhood Predict Triglyceride Level in Adulthood: A 7-Year Longitudinal Study in Girls
Authors: Wiklund Petri , Zhang Xiaobo , Tan Xiao , Keinänen-Kiukaanniemi Sirkka , Alen Markku , Cheng Sulin 
Published: March 2016

AbstractContext:Branched-chain and aromatic amino acids are associated with high risk of developing dyslipidemia and type II diabetes in adults.Objective:This study aimed to examine whether serum amino acid profiles associate with triglyceride concentrations during pubertal growth and predict hypertriglyceridemia in early adulthood.Design:This was a 7.5-year longitudinal study.Setting:The study was conducted at the Health Science Laboratory, University of Jyväskylä.Participants:A total of 396 nondiabetic Finnish girls aged 11.2 ± 0.8 years at the baseline participated in the study.Main Outcome Measures:Body composition was assessed by dual-energy x-ray absorptiometry; serum concentrations of glucose, insulin, and triglyceride by enzymatic photometric methods; and amino acids by nuclear magnetic resonance spectroscopy.Results:Serum leucine and isoleucine correlated significantly with future triglyceride, independent of baseline triglyceride level (P &lt; .05 for all). In early adulthood (at the age of 18 years), these amino acids were significantly associated with hypertriglyceridemia, whereas fat mass and homeostasis model assessment of insulin resistance were not. Leucine was the strongest determinant discriminating subjects with hypertriglyceridemia from those with normal triglyceride level (area under the curve, 0.822; 95% confidence interval, 0.740–0.903; P = .000001).Conclusions:Serum leucine and isoleucine were associated with future serum triglyceride levels in girls during pubertal growth and predicted hypertriglyceridemia in early adulthood. Therefore, these amino acid indices may serve as biomarkers to identify individuals at high risk for developing hypertriglyceridemia and cardiovascular disease later in life. Further studies are needed to elucidate the role these amino acids play in the lipid metabolism.
Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors
Authors: Peng Xinjian , Xu Enquan , Liang Weiwei , Pei Xiaolei , Chen Dixin , Zheng Danfeng , Zhang Yang , Zheng Can , Wang Pingzhang , She Shaoping , Zhang Yan , Ma Jing , Mo Xiaoning , Zhang Yingmei , Ma Dalong , Wang Ying 
Published: March 2016

ABSTRACT
The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members FAM3A, FAM3B, FAM3C and FAM3D. In this study, we found that FAM3D strongly chemoattracted human peripheral blood neutrophils and monocytes. To identify the FAM3D receptor, we used chemotaxis, receptor internalization, Ca2+ flux and radioligand-binding assays in FAM3D-stimulated HEK293 cells that transiently expressed formyl peptide receptor (FPR)1 or FPR2 to show that FAM3D was a high affinity ligand of these receptors, both of which were highly expressed on the surface of neutrophils, and monocytes and macrophages. After being injected into the mouse peritoneal cavity, FAM3D chemoattracted CD11b+ Ly6G+ neutrophils in a short time. In response to FAM3D stimulation, phosphorylated ERK1/2 and phosphorylated p38 MAPK family proteins were upregulated in the mouse neutrophils, and this increase was inhibited upon treatment with an inhibitor of FPR1 or FPR2. FAM3D has been reported to be constitutively expressed in the gastrointestinal tract. We found that FAM3D expression increased significantly during colitis induced by dextran sulfate sodium. Taken together, we propose that FAM3D plays a role in gastrointestinal homeostasis and inflammation through its receptors FPR1 and FPR2.
Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification
Authors: Mendoza-Parra Marco-Antonio , Saravaki Vincent , Cholley Pierre-Etienne , Blum Matthias , Billoré Benjamin , Gronemeyer Hinrich 
Published: March 2016

We have established a certification system for antibodies to be used in chromatin immunoprecipitation assays coupled to massive parallel sequencing (ChIP-seq). This certification comprises a standardized ChIP procedure and the attribution of a numerical quality control indicator (QCi) to biological replicate experiments. The QCi computation is based on a universally applicable quality assessment that quantitates the global deviation of randomly sampled subsets of ChIP-seq dataset with the original genome-aligned sequence reads. Comparison with a QCi database for >28,000 ChIP-seq assays were used to attribute quality grades (ranging from ‘AAA’ to ‘DDD’) to a given dataset. In the present report we used the numerical QC system to assess the factors influencing the quality of ChIP-seq assays, including the nature of the target, the sequencing depth and the commercial source of the antibody. We have used this approach specifically to certify mono and polyclonal antibodies obtained from Active Motif directed against the histone modification marks H3K4me3, H3K27ac and H3K9ac for ChIP-seq. The antibodies received the grades AAA to BBC (www.ngs-qc.org). We propose to attribute such quantitative grading of all antibodies attributed with the label “ChIP-seq grade”.
Managing Catastrophic Climate Risks Under Model Uncertainty Aversion
Authors: Berger Loïc , Emmerling Johannes , Tavoni Massimo 
Published: March 2016

We propose a robust risk management approach to deal with the problem of catastrophic climate change that incorporates both risk and model uncertainty. Using an analytical model of abatement, we show how aversion to model uncertainty influences the optimal level of mitigation. We disentangle the role of preferences from the structure of model uncertainty, which we define by means of a simple measure of disagreement across models. With data from an expert elicitation about climate change catastrophes, we quantify the relative importance of these two effects and calibrate a numerical integrated assessment model of climate change. The results indicate that the structure of model uncertainty, and specifically how model disagreement varies in abatement, is the key driver of optimal abatement and that model uncertainty warrants a higher level of climate change mitigation. This paper was accepted by Manel Baucells, decision analysis.
The Behavior of Investor Flows in Corporate Bond Mutual Funds
Authors: Chen Yong , Qin Nan 
Published: March 2016

This paper provides a comprehensive examination of money flows in corporate bond funds, which, although less researched, represent an important setting to study investor behavior. Based on a large sample of corporate bond funds over 1991–2014, we first show that flows are sensitive to both fund performance and macroeconomic conditions, but unlike equity funds, the flow–performance relationship is not convex. Then, we find that investor flows can predict fund performance. More importantly, the predictability cannot be explained by return momentum or price pressure but is subsumed by performance persistence. Finally, an examination of idiosyncratic flows reveals little evidence that fund investors use finer-than-public information. This paper was accepted by Lauren Cohen, finance.
Lowe T(V): Directing masculinity in a new century
Authors: Vayo Lloyd Isaac 
Published: March 2016

Abstract
Though a generally innocuous, if funny, series of advertisements, the recent set of Rob Lowe commercials for DIRECTV offers something else beyond the various selling points of a specific television service. The commercials, each of which portray regular Rob Lowe alongside an unfortunate alter ego (‘Scrawny Arms’, ‘Painfully Awkward’, ‘Overly Paranoid’, ‘Crazy Hairy’, ‘Total Deadbeat’, ‘Creepy’, ‘Peaked in High School’ and ‘Meathead’), provide a catalogue of twenty-first-century masculinities. By contrasting the regular Rob Lowe alongside his lesser iterations, the commercials cast a critical eye on traditional masculinity, calling into question both physical (‘Scrawny Arms’, ‘Crazy Hairy’ and ‘Meathead’) and behavioural (‘Painfully Awkward’, ‘Overly Paranoid’, ‘Total Deadbeat’, ‘Creepy’ and ‘Peaked in High School’) extremes. When read against the particulars of Lowe’s own experiences (as found in his 2011 autobiography Stories I Only Tell My Friends and its 2014 companion piece Love Life), in which he has either inhabited or encountered those alter egos throughout his life and career, the commercials suggest that twenty-first-century masculinities, in the person of Lowe, are expansive.
‘This is what I’ve always wanted’: Bromance and the evolution of male intimacy in the Jump Street films
Authors: Ciasullo Ann M. , Magill David 
Published: March 2016

Abstract
For over a decade now, American popular culture has registered its fascination with the relationship between heterosexual men through the film genre of the ‘bromance’. We might have predicted the development of this genre, for it mirrors our recent shift in twenty-first century masculinities not only towards renewed fraternal connection but also towards more open emotional connection. This article focuses on the recent Jump Street movies as both nods to their ‘bromantic’ predecessors and responses to the established narrative boundaries of the genre. 21 and 22 Jump Street not only test the limits but, we would argue, explode them via three distinct but interrelated strategies: through the narrative structure of the films themselves, particularly in their representation of the bromantic relationship and the lack of heterosexual narrative closure; through their mixing of genres (buddy movie/action movie/romance/bromance); and through the queer inter- and extratextual narrative generated by what film critic Richard Dyer calls the ‘star power’ of the two leads, especially Channing Tatum. An examination of these strategies will reveal that the Jump Street films both define and defy bromantic conventions, contributing to a new understanding of male intimacy in US mainstream culture.
Weak Chord-Arc Curves and Double-Dome
Quasisymmetric Spheres
Authors: Vellis Vyron 
Published: March 2016

Abstract
Let Ω be a planar Jordan domain and α > 0. We consider double-dome-like surfaces Σ(Ω, tα) over Ω where the height of the surface over any point x ∈ Ωequals dist(x, ∂Ω)α. We identify the necessary and sufficient conditions in terms of and α so that these surfaces are quasisymmetric to S2 and we show that Σ(Ω, tα) is quasisymmetric to the unit sphere S2 if and only if it is linearly locally connected and Ahlfors 2-regular.
Invariant Curves of Mappings with Averaged Small Twist
Authors: Ortega Rafael 
Published: March 2016

Abstract
The Invariant Curve Theorem asserts the existence of invariant curves for certain planar mappings of the type θ1 = θ + ω + δα(r) + . . . , r1 = r + . . ., where α satisfies the twist condition α′ (r) ≠ 0. This paper discusses the possibility of obtaining variants of this Theorem for mappings of the more general type θ1 = θ + ω + δl1(θ, r) + . . . , r1 = r + l2(θ, r) + . . .. It is well known that if ω satisfies a diophantine condition then the twist condition can be replaced by

(θ, r),dθ ≠ 0. In this paper it will be shown that this is also the case for any number ω which is not commensurable with 2π (without imposing any arithmetic condition). As an application of this result to differential equations we shall discuss the problem of boundedness for a class of piecewise linear forced oscillators.