bluuebunny/crossref_metadata_2025_split huggingface dataset:
DETERMINATION DES DENIVELLATIONS ET DES COURANTS DE MAREE
Authors: Gohin Par F. 
Published: June 2017

Les premiers resultats positifs obtenus dans la prevision des amplitudes de la maree dans les ports datent de plusieurs siecles ; depuis fort longtemps les courants de maree dans les mers coheres sont famihers aux navigateurs. Rappelons simplement qu'encore de nos jours, la prevision des marnages (difference de niveau entre pleine et basse raer) et des phases (decalages de la plelne mer par rapport au passage de la lune au mendien) s'appuie sur 1'analyse harmomque des enregistrements de maregraphes. Cette analyse differe de celle de FDURIER: les penodes des differentes composantes ne sont pas des sous-multiples entiers d'une meme penode elementaire, mais ont des valeurs connues avec toute la precision desiree. La composante principale, dans nos regions europeennes du moms, represente la maree qui serait due a une lune fictive tournant a distance constante de la terre et a Vitesse constante dans le plan de l'equateur (maree dite M2). Depuis la fin du siecle dernier des recherches tres nombreuses ont ete faites parmi lesquelles ll faut citer celles de POINCARE (methode theonque de determination des amplitudes et courants), HARRIS (trace des hgnes cotidales - c'est-d-dire equiphases - de la maree M2), HANSEN (determination des denivellations et courants en Mer du Nord), DOODSON (determination des hgnes cotidales et equiamphtudes dans les mers bordant la
GRANDE RRET/1GNE).
DETERMINATION OF THE WAVE ATTACK ANTICIPATED UPON A STRUCTURE FROM LABORATORY AND FIELD OBSERVATIONS
Authors: Venis W.A. 
Published: June 2017

Model tests have been carried out to obtain an insight into the magnitude of the wave-pressures in various situations. These tests showed, that sharp high pressure peaks occur in addition to the pressures caused by the reflecting of the waves, which pressures are quasi-static. As the structure can be compared with a multiple mass-spring system these pressure-peaks may cause the whole construction to vibrate. Wave-attack therefore can be expressed in terms of impact. Moreover, calculations revealed that the impact pressures were critical factors in determining the strength of the structure.
So many model tests were carried out to determine the design and location of the sluices. These tests involved numerous water-levels discharges and waves. Regarding the pressure-peaks a comparative study was made in the model, which led to the structure being designed in such a way that the occurrence of critical impacts was reduced to an acceptable minimum. As it was impossible to avoid the occurrence of impact pressures entirely it remained necessary to determine a basic load for the structure that takes care of the impact pressures. As it has not yet appeared possible physically to determine a theoretical maximum for the impact pressures, it has to be borne in mind that there is a probability that each pressure measured will be exceeded. So this paper describes, how the cumulative frequency curve of the impacts for the case mentioned in 1.1 sub a, which served as a basis for determining the basic load was arrived at by a certain combination of laboratory and field observations. The data used for this purpose were a. Results of wave-impact measurements on a model of the sluices. This model, built in accordance with the results of the comparative study, was situated in the wind-flume of the "de Voorst" hydraulic laboratory. b. Wave height measurements in the Haringvliet during 1957 and 1958. c. Wind-speed measurements on board the lightship Qoeree, likewise during 1957 and 1958. d. Tidal registrations at Hellevoetsluis from 1920 to 1960. e. Wind-force data from the Hook of Holland, likewise from 1920 to 1960.
Advances in understanding river‐groundwater interactions
Authors: Brunner Philip , Therrien René , Renard Philippe , Simmons Craig T. , Franssen Harrie‐Jan Hendricks 
Published: June 2017

AbstractRiver‐groundwater interactions are at the core of a wide range of major contemporary challenges, including the provision of high‐quality drinking water in sufficient quantities, the loss of biodiversity in river ecosystems, or the management of environmental flow regimes. This paper reviews state of the art approaches in characterizing and modeling river and groundwater interactions. Our review covers a wide range of approaches, including remote sensing to characterize the streambed, emerging methods to measure exchange fluxes between rivers and groundwater, and developments in several disciplines relevant to the river‐groundwater interface. We discuss approaches for automated calibration, and real‐time modeling, which improve the simulation and understanding of river‐groundwater interactions. Although the integration of these various approaches and disciplines is advancing, major research gaps remain to be filled to allow more complete and quantitative integration across disciplines. New possibilities for generating realistic distributions of streambed properties, in combination with more data and novel data types, have great potential to improve our understanding and predictive capabilities for river‐groundwater systems, especially in combination with the integrated simulation of the river and groundwater flow as well as calibration methods. Understanding the implications of different data types and resolution, the development of highly instrumented field sites, ongoing model development, and the ultimate integration of models and data are important future research areas. These developments are required to expand our current understanding to do justice to the complexity of natural systems.
Stereoselective Mannich Reaction of N‐(tert‐Butylsulfinyl)imines with 3‐Fluorooxindoles and Fluoroacetamides
Authors: Chen Xiangyu , Li Ya , Zhao Jianbo , Zheng Buquan , Lu Qi , Ren Xinfeng 
Published: June 2017

AbstractA diastereoselective Mannich reaction has been developed for the construction of stereogenic C−F units by the reaction of α‐fluoro‐substituted amides, including highly activated 3‐fluoro‐oxindoles, and simple linear fluoroacetamides with N‐tert‐butylsulfinylimines. This method provides a concise route to a variety of structurally diverse α‐fluoro‐β‐amino amides containing stereogenic fluorinated carbon centers. This protocol has the benefit of using readily accessible starting materials and is operationally simple. The Mannich reactions of cyclic and linear α‐fluoro‐substituted amides resulted in different stereochemical outcomes, suggesting that these substrates reacted via closed and open transition states, respectively.magnified image
Evaluation of baseline frequency of sister chromatid exchanges in an Italian population according to age, sex, smoking habits, and gene polymorphisms
Authors: Santovito Alfredo , Gendusa Claudio , Cervella Piero 
Published: June 2017

AbstractObjectivesIncreased SCEs frequencies in human lymphocytes are an indicator of spontaneous chromosome instability and could be influenced by different exogenous and endogenous factors. In this study, we evaluated the influence of age, sex, smoking habits, and genetic polymorphisms on the background levels of SCEs in peripheral blood lymphocytes.MethodsTwo hundred‐thirty healthy Italian subjects were recruited. Data about age, sex and smoking habits were recorded. Subjects were also genotyped for GSTT1, GSTM1, GSTP1 A/G, CYP1A1 Ile/Val, CYP2C19 G/A, ERCC2/XPD Lys751Gln, XRCC1 Arg194ATrp, XRCC1 Arg399Gln, and XRCC1Arg208His gene polymorphisms.ResultsThe frequency of SCEs/cell was 5.15 ± 1.87, with females showing a significantly higher SCEs value with respect to males (5.36 ± 2.10 and 4.82 ± 1.39, respectively). Smokers showed significantly increased levels of SCEs with respect to nonsmokers (5.93 ± 1.75 and 4.70 ± 1.79, respectively) whereas no differences were observed between heavy and light smokers. Age correlated with the RI value (P = .01) but not with the SCEs frequency (P = 07), although the 31‐40 age group showed a significantly lower SCEs frequency with respect to the other age groups. A significant association was also found between GSTP2C19‐AA, GSTT1‐null, GSTM1‐null, ERCC2/XPD Gln751Gln, and XRCC1 His208His genotypes, and higher frequencies of SCEs.ConclusionWe describe the association between some phase I, phase II, and DNA‐repair gene polymorphisms with increased SCEs frequencies, reinforcing the importance of genetic analysis in biomonitoring studies. Sex and age were found to be important endogenous factors that affect the level of genomic damage and the replicative capacity of cells, respectively.
Diet of the prehistoric population of Rapa Nui (Easter Island, Chile) shows environmental adaptation and resilience
Authors: Jarman Catrine L. , Larsen Thomas , Hunt Terry , Lipo Carl , Solsvik Reidar , Wallsgrove Natalie , Ka'apu‐Lyons Cassie , Close Hilary G. , Popp Brian N. 
Published: June 2017

AbstractObjectivesThe Rapa Nui “ecocide” narrative questions whether the prehistoric population caused an avoidable ecological disaster through rapid deforestation and over‐exploitation of natural resources. The objective of this study was to characterize prehistoric human diets to shed light on human adaptability and land use in an island environment with limited resources.Materials and methodsMaterials for this study included human, faunal, and botanical remains from the archaeological sites Anakena and Ahu Tepeu on Rapa Nui, dating from c. 1400 AD to the historic period, and modern reference material. We used bulk carbon and nitrogen isotope analyses and amino acid compound specific isotope analyses (AA‐CSIA) of collagen isolated from prehistoric human and faunal bone, to assess the use of marine versus terrestrial resources and to investigate the underlying baseline values. Similar isotope analyses of archaeological and modern botanical and marine samples were used to characterize the local environment.ResultsResults of carbon and nitrogen AA‐CSIA independently show that around half the protein in diets from the humans measured came from marine sources; markedly higher than previous estimates. We also observed higher δ15N values in human collagen than could be expected from the local environment.DiscussionOur results suggest highly elevated δ15N values could only have come from consumption of crops grown in substantially manipulated soils. These findings strongly suggest that the prehistoric population adapted and exhibited astute environmental awareness in a harsh environment with nutrient poor soils. Our results also have implications for evaluating marine reservoir corrections of radiocarbon dates.
Increased expression of TIPE2 in alternatively activated macrophages is associated with eosinophilic inflammation and disease severity in chronic rhinosinusitis with nasal polyps
Authors: Yao Yin , Wang Zhi‐Chao , Liu Jin‐Xin , Ma Jin , Chen Cai‐Ling , Deng Yi‐Ke , Liao Bo , Wang Nan , Wang Heng , Ning Qin , Liu Zheng 
Published: June 2017

BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disorder characterized by exaggerated local immune responses. Tumor necrosis factor‐α–induced protein 8–like 2 (TIPE2) is a novel protein with potential immune modulating function. The expression and function of TIPE2 in human airway diseases are unclear.MethodsThe expression of TIPE2 in sinonasal mucosal samples was assessed by means of quantitative reverse transcript–polymerse chain reaction, immunohistochemistry, and Western blotting. The human monocytic/macrophage cell line, THP‐1 cells, was stimulated with various cytokines. Computed tomography (CT) scan images, endoscopic findings, and symptoms were scored.ResultsCompared with non‐eosinophilic polyps and control mucosa, the mRNA and protein expression of TIPE2 was significantly upregulated in eosinophilic polyps, with a further increase in those with asthma. The number of CD68+CD163+ alternatively activated (M2) macrophages was increased in eosinophilic polyps. TIPE2 was mainly expressed by M2 macrophages in sinonasal mucosa and its expression was upregulated in M2 macrophages in eosinophilic polyps. Interleukin (IL)‐4 and IL‐13, but not interferon (IFN)‐γ or IL‐17A, induced TIPE2 expression in differentiated THP‐1 cells. The mRNA levels of IL‐4 and IL‐13 correlated with the mRNA levels of TIPE2 and M2 macrophage markers in sinonasal mucosa. Importantly, the number of TIPE2+ cells, particularly TIPE2+CD163+CD68+ M2 macrophages, correlated positively with the number of eosinophils and total inflammatory cells in sinonasal mucosa, as well as disease duration, CT scores, hyposmia scores, and polyp size in CRSwNP.ConclusionThe T‐helper 2 milieu is able to induce TIPE2 expression in macrophages. TIPE2‐positive M2 macrophages potentially contribute to eosinophilic inflammation and disease progression in CRSwNP.
Simultane endo‐ und exo‐Komplexbildung von Pyridin[4]aren‐Dimeren mit neutralen und anionischen Gästen
Authors: Kiesilä Anniina , Kivijärvi Lauri , Beyeh Ngong Kodiah , Moilanen Jani O. , Groessl Michael , Rothe Tatiana , Götz Sven , Topić Filip , Rissanen Kari , Lützen Arne , Kalenius Elina 
Published: June 2017

AbstractDie Bildung von Wirt‐Gast‐Komplexen aus Hexafluorophosphat (PF6−) und Tetraisobutyloctahydroxypyridin[4]aren (1) wurde in der Gasphase (ESI‐QTOF‐MS, IM‐MS, DFT‐Rechnungen), im Festkörper (Röntgenstrukturanalyse) und in Chloroformlösungen (1H‐, 19F‐ und DOSY‐NMR) umfassend untersucht. In allen Aggregatzuständen wurde eine simultane endo‐Komplexierung von Lösungsmittelmolekülen und eine exo‐Komplexierung von PF6−‐Anionen mit dem Pyridin[4]aren‐Dimer beobachtet. Während ähnliche ternäre Komplexe im Festkörper bereits öfter beschrieben wurden, ist ein solches Verhalten in der Gasphase bislang einzigartig und noch nie zuvor beobachtet worden.
On Finite‐Time Stabilization of Active Disturbance Rejection Control for Uncertain Nonlinear Systems
Authors: Wang Qing , Ran Maopeng , Dong Chaoyang 
Published: June 2017

AbstractThis paper designs the active disturbance rejection control (ADRC) to achieve finite‐time stabilization for a class of uncertain nonlinear systems. The proposed control incorporates both an extended state observer (ESO) as well as an adaptive sliding mode controller. The ESO is utilized to estimate the full system states and the total uncertainties, and the adaptive strategy is incorporated to deal with the estimation errors. It is proved that, with the application of the proposed control law, semi‐global finite‐time stabilization can be achieved. Effectiveness of the proposed method is illustrated with a numerical example.
Elevated levels of liver methylglyoxal and d‐lactate in early‐stage hepatitis in rats
Authors: Wang Wen‐Chuang , Chou Chu‐Kuang , Chuang Ming‐Cheng , Li Yi‐Chieh , Lee Jen‐Ai 
Published: June 2017

AbstractMethylglyoxal (MGO) is highly cytotoxic and its levels are elevated in diabetes, nephropathy and atherosclerosis. However, it has never been studied in liver disease. For this reason, we aimed to assess the levels of MGO and its metabolite d‐lactate in an early hepatitis model. Wistar rats were administered CCl4 (0.75 mL/kg, i.p.) to induce hepatitis. In either CCl4‐treated or untreated rats, alanine transaminase and aspartate transaminase levels did not change over the course of the study, indicating that significant liver damage did not occur following CCl4 treatment. However, the levels of MGO and d‐lactate were higher in the livers of CCl4‐treated animals than in untreated animals (MGO: 128.2 ± 18.8 and 248.1 ± 64.9 μg/g protein, p < 0.01; d‐lactate: 0.860 ± 0.040 and 1.293 ± 0.078 μmol/g protein, respectively p < 0.01). Furthermore, in untreated and treated animals, serum d‐lactate levels were 57.65 ± 2.59 and 92.16 ± 16.69 μm and urine d‐lactate levels were 1.060 ± 0.007 and 1.555 ± 0.366 μmol/mg UCr, respectively (p < 0.01). These data show that in this model of early‐stage liver damage, the levels of MGO and its metabolite d‐lactate are elevated and that d‐lactate could be useful as a reference marker for the early stage of hepatitis.
Data‐enabled cognitive modeling: Validating student engineers’ fuzzy design‐based decision‐making in a virtual design problem
Authors: Arastoopour Irgens Golnaz , Chesler Naomi C. , Linderoth Jeffrey T. , Williamson Shaffer David 
Published: June 2017

AbstractThe ability of future engineering professionals to solve complex real‐world problems depends on their design education and training. Because engineers engage with open‐ended problems in which there are unknown parameters and multiple competing objectives, they engage in fuzzy decision‐making, a method of making decisions that takes into account inherent imprecisions and uncertainties in the real world. In the design‐based decision‐making field, few studies have applied fuzzy decision‐making models to actual decision‐making process data. Thus, in this study, we use datasets on student decision‐making processes to validate approximate fuzzy models of student decision‐making, which we call data‐enabled cognitive modeling. The results of this study (1) show that simulated design problems provide rich datasets that enable analysis of student design decision‐making and (2) validate models of student design cognition that can inform future design curricula and help educators understand how students think about design problems.
Anterior mitral leaflet perforation: a rare complication of radiofrequency ablation for paroxysmal supraventricular tachycardia
Authors: Han Jiancheng , Xu Jin , He Yihua 
Published: June 2017

Key Clinical MessageA 9‐year‐old girl with a ten‐day history of palpitations was referred for the assessment of mitral regurgitation. She had had RF ablation for paroxysmal supraventricular tachycardia 5 years previously. Echocardiography showed isolated anterior mitral leaflet perforation. Surgical findings confirmed the echocardiographic assessment.
Continuous Redirection and Separation of Microbeads by Faradaic Ion Concentration Polarization
Authors: Davies Collin D. , Yoon Eunsoo , Crooks Richard M. 
Published: June 2017

AbstractHerein we report that faradaic ion concentration polarization (fICP) can be used to sort and separate micron‐scale objects within a bifurcated microelectrochemical device. In fICP, a bipolar electrode (BPE) is activated by a driving voltage, which results in formation of an ion depletion zone (IDZ) and an ion enrichment zone (IEZ). By judicious control of the placement of the BPE and control of the driving voltage, the IDZ and IEZ can be manipulated in a way that directs charged microbeads into a particular channel of the microelectrochemical device. The key findings are threefold. First, ∼100 % microbead redirection and separation may be achieved by fICP. Second, the tracking of microbeads as they traverse the channel length permits visualization of local variations in electroosmotic flow (EOF). Third, variations in solution conductivity in different regions of the channel lead to differences in EOF that exert a significant influence over microbead trajectory.
Latent‐lSVM classification of very high‐dimensional and large‐scale multi‐class datasets
Authors: Do Thanh‐Nghi , Poulet François 
Published: June 2017

SummaryWe propose a new parallel learning algorithm of latent local support vector machines (SVM), called latent‐lSVM for effectively classifying very high‐dimensional and large‐scale multi‐class datasets. The common framework of texts/images classification tasks using the Bag‐Of‐(visual)‐Words model for the data representation leads to hard classification problem with thousands of dimensions and hundreds of classes. Our latent‐lSVM algorithm performs these complex tasks into two main steps. The first one is to use latent Dirichlet allocation for assigning the datapoint (text/image) to some topics (clusters) with the corresponding probabilities. This aims at reducing the number of classes and the number of datapoints in the cluster compared to the full dataset, followed by the second one: to learn in a parallel way nonlinear SVM models to classify data clusters locally. The numerical test results on nine real datasets show that the latent‐lSVM algorithm achieves very high accuracy compared to state‐of‐the‐art algorithms. An example of its effectiveness is given with an accuracy of 70.14% obtained in the classification of Book dataset having 100 000 individuals in 89 821 dimensional input space and 661 classes in 11.2 minutes using a PC Intel(R) Core i7‐4790 CPU, 3.6 GHz, 4 cores.
Triple‐Doped Monolayer Graphene with Boron, Nitrogen, Aluminum, Silicon, Phosphorus, and Sulfur
Authors: Ullah Saif , Denis Pablo A. , Sato Fernando 
Published: June 2017

AbstractThe cover image illustrates the heteroatom doping of graphene extended to a new limit. First‐principles calculations revealed that triple‐doped graphene systems exhibit exciting electronic and catalytic properties. Read the full text of the article at 10.1002/cphc.201700278.
Minimalistic Liquid‐Assisted Route to Highly Crystalline α‐Zirconium Phosphate
Authors: Cheng Yu , Wang Xiaodong (Tony) , Jaenicke Stephan , Chuah Gaik‐Khuan 
Published: June 2017

AbstractZirconium phosphates have potential applications in areas of ion exchange, catalysis, photochemistry, and biotechnology. However, synthesis methodologies to form crystalline α‐zirconium phosphate (Zr(HPO4)2⋅H2O) typically involve the use of excess phosphoric acid, addition of HF or oxalic acid and long reflux times or hydrothermal conditions. A minimalistic sustainable route to its synthesis has been developed by using only zirconium oxychloride and concentrated phosphoric acid to form highly crystalline α‐zirconium phosphate within hours. The morphology can be changed from platelets to rod‐shaped particles by fluoride addition. By varying the temperature and time, α‐zirconium phosphate with particle sizes from nanometers to microns can be obtained. Key features of this minimal solvent synthesis are the excellent yields obtained with high atom economy under mild conditions and ease of scalability.
Urinary tract involvement of mantle cell lymphoma diagnosed by urine cytology
Authors: Hamele‐Bena Diane , Gonzalez Abel Arnoldo 
Published: June 2017

AbstractUrinary tract lymphoma is unusual, with the kidney being the most commonly reported site of involvement. Urinary bladder involvement by lymphoma is rare. Mantle cell lymphoma (MCL) is a relatively uncommon type of lymphoma. Herein, we report a case of MCL of the urinary bladder diagnosed by urine cytology, with confirmatory immunocytochemical stains, which has not previously been reported in the literature.
Extracellular vesicles mediate intercellular communication: Transfer of functionally active microRNAs by microvesicles into phagocytes
Authors: Claßen Laura , Tykocinski Lars‐Oliver , Wiedmann Felix , Birr Carolin , Schiller Petra , Tucher Christine , Krienke Stefan , Raab Marc‐Steffen , Blank Norbert , Lorenz Hanns‐Martin , Schiller Martin 
Published: June 2017

AbstractCell activation and apoptosis lead to the formation of extracellular vesicles (EVs) such as exosomes or microvesicles (MVs). EVs have been shown to modulate immune responses; recently, MVs were described to carry microRNA (miRNA) and a role for MVs in the pathogenesis of autoimmune diseases has been discussed. Here we systematically characterized MVs and exosomes according to their release stimuli. The miRNA content of viable or apoptotic human T lymphocytes and the corresponding MVs was analyzed. miRNA, protein and surface marker expression, as well as cytokine release by human monocytes was measured after EV engulfment. Finally, miRNA expression in T lymphocytes and MVs of healthy individuals was compared with those of systemic lupus erythematosus (SLE) patients. We demonstrate that, depending on the stimuli, distinct subtypes of EVs are released, differing in size and carrying a specific RNA profile. We observed an accumulation of distinct miRNAs in MVs after induction of apoptosis and the transfer of functional miRNA by MVs into human monocytes. MVs released from apoptotic cells provoke less of an inflammatory response than those released from viable cells. MiR‐155*, miR‐34b and miR‐34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals.