bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Validity and Reliability of the Beliefs About Medicines Questionnaire in Low-Income, Spanish-Speaking Patients With Diabetes in the United States
Authors: Jimenez Krystal , Vargas Cristina , Garcia Karla , Guzman Herlinda , Angulo Marco , Billimek John 
Published: November 2016

Purpose The purpose of this study was to examine the reliability and validity of a Spanish version of the Beliefs about Medicines Questionnaire (BMQ) as a measure to evaluate beliefs about medications and to differentiate adherent from nonadherent patients among low-income Latino patients with diabetes in the United States. Methods Seventy-three patients were administered the BMQ and surveyed for evidence of medication nonadherence. Internal consistency of the BMQ was assessed by Cronbach’s alpha along with performing a confirmatory factor analysis. Criterion validity was assessed by comparing mean scores on 3 subscales of the BMQ (General Overuse, General Harm, and Specific Necessity–Concerns difference score) between adherent patients and patients reporting nonadherence for 3 different reasons (unintentional nonadherence, cost-related nonadherence, and nonadherence due to reasons other than cost) using independent samples t tests. Results The BMQ is a reliable instrument to examine beliefs about medications in this Spanish-speaking population. Construct validity testing shows nearly identical factor loading as the original construct map. General Overuse scores were significantly more negative for patients reporting each reason for nonadherence compared with their adherent counterparts. Necessity–Concerns difference scores were significantly more negative for patients reporting nonadherence for reasons other than cost compared with those who did not report this reason for nonadherence. Conclusion The Spanish version of the BMQ is appropriate to assess beliefs about medications in Latino patients with type 2 diabetes in the United States and may help identify patients who become nonadherent to medications for reasons other than out-of-pocket costs.
Alpha Angle Measurements in Healthy Adult Volunteers Vary Depending on the MRI Plane Acquisition Used
Authors: Golfam Mohammad , Di Primio Luigia A. , Beaulé Paul E. , Hack Kalesha , Schweitzer Mark E. 
Published: November 2016

Background: It has been shown that cam deformities are located at a more anterosuperior location than was previously described. Purpose: To establish, in a large group of asymptomatic participants, the normative range of the alpha angle in the anterosuperior location in both the oblique axial and radial views of magnetic resonance imaging (MRI). Study Design: Cross-sectional study; Level of evidence, 3. Methods: In 197 asymptomatic participants (394 asymptomatic hips) with a mean age of 29.4 years (range, 21.4-50.6 years), T1-weighted MRI scans were studied. The anterosuperior alpha angle measurement was performed by 2 observers using a previously described methodology and also using the radial view. The intraclass correlation coefficient (ICC) was determined for interobserver and intraobserver reliability. Descriptive statistics, the Student t test, correlation studies, and the Bland-Altman technique were used for data analysis. Results: The ICC for interobserver and intraobserver reproducibility was 0.74 (good agreement) and 0.84 (very good agreement), respectively. Anterosuperiorly, the mean (±SD) alpha angles in the oblique axial and radial views were 45.11° ± 8.52° and 50.30° ± 7.91°, respectively ( P < .0001). The upper limits of the 95% reference interval for the oblique axial and radial views were 63° and 66°, respectively. In the oblique axial view, the mean (±SD) alpha angle for male participants was 48.3° ± 7.5° compared with 42.6° ± 6.2° for female participants ( P < .0001), and in the radial view, it was 53.0° ± 7.1° compared with 48.1° ± 5.6°, respectively ( P < .0001). Linear regression analysis demonstrated an insignificant relationship between age and alpha angle, regardless of the imaging plane ( r2 = 0.06). Conclusion: We suggest using a higher threshold of 63° (in the oblique axial view) and 66° (in the radial view) at the 1:30 clockface position for the diagnosis of a cam-type deformity. This is significantly higher than 50° to 55° at the 3-o’clock position traditionally used based on the oblique axial view that has been initially described.
Perfusion of the Rotator Cuff Tendon According to the Repair Configuration Using an Indocyanine Green Fluorescence Arthroscope: A Preliminary Report
Authors: Kim Sae Hoon , Cho Won-Sang , Joung Ho-Yun , Choi Young Eun , Jung Minwoong 
Published: November 2016

Background: The disturbance of rotator cuff tendon perfusion has been connected with the suture-bridge configuration repair (SBCR) technique; however, in vivo assessments of the tendon blood supply have been problematic with other modalities. An evaluation of tissue perfusion by an indocyanine green (ICG) fluorescence arthroscope has been developed to counteract this difficulty. Purpose: To verify the hindrance of perfusion in SBCR, we used an ICG fluorescence camera to compare parallel-type transosseous repair (PTR) and SBCR in rabbits immediately and at 3 days after rotator cuff repair. Study Design: Controlled laboratory study. Methods: Acute rotator cuff repair was performed on the shoulders of 10 rabbits. Both shoulders were repaired using either PTR or SBCR. For PTR, simple repair was performed through 2 parallel transosseous tunnels created using a microdrill. For SBCR, 2 additional crisscross transosseous tunnels were added to mimic arthroscopic SBCR. Immediately after repair, ICG was injected through the ear vein, and images were recorded using an ICG fluorescence camera. Tendon perfusion was compared by measuring fluorescence intensity using ImageJ software in both methods. At 3 days after rotator cuff repair, a reassessment of ICG fluorescence was performed. In addition, as a subsidiary study, a comparison of each repair method and a healthy tendon was performed (PTR vs healthy tendon and SBCR vs healthy tendon). Six rabbits (3 for each comparison) were included. Results: Immediately after rotator cuff repair, the mean (±SD) grayscale intensity of ICG fluorescence was weaker in SBCR than PTR in 10 specimens (65.9 ± 47.6 vs 84.3 ± 53.4 per pixel, respectively; P = .003). At 3 days after repair, 8 specimens were included in the analysis because suture strands failed in 2 specimens in SBCR. The mean intensity of fluorescence was still weaker in SBCR compared with PTR (52.5 ± 13.7 vs 60.2 ± 22.7 per pixel, respectively; P = .077). The mean fluorescence intensity compared with a healthy tendon was 83.2% ± 9.5% in PTR and 63.2% ± 13.2% in SBCR. Conclusion: Our ICG fluorescence camera system was able to detect ICG fluorescence in an acute rabbit rotator cuff repair model. SBCR showed inferior tendon perfusion immediately after repair. At 3 days after repair, SBCR still showed inferior fluorescence intensity, although it did not reach statistical significance. Clinical Relevance: In this study, SBCR hindered perfusion at the tendon in the compressed area. This finding may affect rotator cuff tendon healing and failure mode.
iNKT and memory B-cell alterations in HHV-8 multicentric Castleman disease
Authors: Sbihi Zineb , Dossier Antoine , Boutboul David , Galicier Lionel , Parizot Christophe , Emarre Amandine , Hoareau Bénédicte , Dupin Nicolas , Marcelin Anne-Geneviève , Oudin Anne , Fieschi Claire , Agbalika Félix , Autran Brigitte , Oksenhendler Eric , Carcelain Guislaine 
Published: November 2016

Key PointsHHV-8 MCD is associated with a decrease of iNKT and memory B cells. iNKT decrease contributes to B-cell abnormalities in coculture experiments.
3D strength surfaces for ankle plantar‐ and dorsi‐flexion in healthy adults: an isometric and isokinetic dynamometry study
Authors: Hussain Sara J. , Frey‐Law Laura 
Published: November 2016

AbstractBackgroundThe ankle is an important component of the human kinetic chain, and deficits in ankle strength can negatively impact functional tasks such as balance and gait. While peak torque is influenced by joint angle and movement velocity, ankle strength is typically reported for a single angle or movement speed. To better identify deficits and track recovery of ankle strength after injury or surgical intervention, ankle strength across a range of movement velocities and joint angles in healthy adults is needed. Thus, the primary goals of this study were to generate a database of strength values and 3‐dimensional strength surface models for plantarflexion (PF) and dorsiflexion (DF) ankle strength in healthy men and women. Secondary goals were to develop a means to estimate ankle strength percentiles as well as examine predictors of maximal ankle strength in healthy adults.MethodsUsing an isokinetic dynamometer, we tested PF and DF peak torques at five joint angles (−10° [DF], 0° [neutral], 10° [PF], 20° [PF] and 30° [PF]) and six velocities (0°/s, 30°/s, 60°/s, 90°/s, 120°/s and 180°/s) in 53 healthy adults. These data were used to generate 3D plots, or “strength surfaces”, for males and females for each direction; surfaces were fit using a logistic equation. We also tested predictors of ankle strength, including height, weight, sex, and self‐reported physical activity levels.ResultsTorque‐velocity and torque‐angle relationships at the ankle interact, indicating that these relationships are interdependent and best modeled using 3D surfaces. Sex was the strongest predictor of ankle strength over height, weight, and self‐reported physical activity levels. 79 to 97 % of the variance in mean peak torque was explained by joint angle and movement velocity using logistic equations, for men and women and PF and DF directions separately.ConclusionsThe 3D strength data and surface models provide a more comprehensive dataset of ankle strength in healthy adults than previously reported. These models may allow researchers and clinicians to quantify ankle strength deficits and track recovery in patient populations, using angle‐ and velocity‐specific ankle strength values and/or strength percentiles from healthy adults.
Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta
Authors: Du Wen Jing , Chi Ying , Yang Zhou Xin , Li Zong Jin , Cui Jun Jie , Song Bao Quan , Li Xue , Yang Shao Guang , Han Zhi Bo , Han Zhong Chao 
Published: November 2016

Abstract
Background
Mesenchymal stem cells (MSCs) have been widely proven effective for therapeutic angiogenesis in ischemia animal models as well as clinical vascular diseases. Because of the invasive method, limited resources, and aging problems of adult tissue-derived MSCs, more perinatal tissue-derived MSCs have been isolated and studied as promising substitutable MSCs for cell transplantation. However, fewer studies have comparatively studied the angiogenic efficacy of MSCs derived from different tissues sources. Here, we evaluated whether the in-situ environment would affect the angiogenic potential of MSCs.

Methods
We harvested MSCs from adult bone marrow (BMSCs), adipose tissue (AMSCs), perinatal umbilical cord (UMSCs), and placental chorionic villi (PMSCs), and studied their “MSC identity” by flow cytometry and in-vitro trilineage differentiation assay. Then we comparatively studied their endothelial differentiation capabilities and paracrine actions side by side in vitro.

Results
Our data showed that UMSCs and PMSCs fitted well with the minimum standard of MSCs as well as BMSCs and AMSCs. Interestingly, we found that MSCs regardless of their tissue origins could develop similar endothelial-relevant functions in vitro, including producing eNOS and uptaking ac-LDL during endothelial differentiation in spite of their feeble expression of endothelial-related genes and proteins. Additionally, we surprisingly found that BMSCs and PMSCs could directly form tubular structures in vitro on Matrigel and their conditioned medium showed significant proangiogenic bioactivities on endothelial cells in vitro compared with those of AMSCs and UMSCs. Besides, several angiogenic genes were upregulated in BMSCs and PMSCs in comparison with AMSCs and UMSCs. Moreover, enzyme-linked immunosorbent assay further confirmed that BMSCs secreted much more VEGF, and PMSCs secreted much more HGF and PGE2.

Conclusions
Our study demonstrated the heterogeneous proangiogenic properties of MSCs derived from different tissue origins, and the in vivo isolated environment might contribute to these differences. Our study suggested that MSCs derived from bone marrow and placental chorionic villi might be preferred in clinical application for therapeutic angiogenesis.
α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction
Authors: Jurado Jaime , de Navascués Joaquín , Gorfinkiel Nicole 
Published: November 2016

ABSTRACT
We have investigated how cell contractility and adhesion are functionally integrated during epithelial morphogenesis. To this end, we have analysed the role of α-Catenin, a key molecule linking E-Cadherin-based adhesion and the actomyosin cytoskeleton, during Drosophila embryonic dorsal closure, by studying a newly developed allelic series. We find that α-Catenin regulates pulsatile apical contraction in the amnioserosa, the main force-generating tissue driving closure of the embryonic epidermis. α-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin, also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability. Furthermore, we uncover a genetic interaction between α-Catenin and Vinculin, and a tension-dependent recruitment of Vinculin to amniosersoa apical cell membranes, suggesting the existence of a mechano-sensitive module operating in this tissue.
Comparing Apples and Oranges: Query Trade-off in Submodular Maximization
Authors: Buchbinder Niv , Feldman Moran , Schwartz Roy 
Published: November 2016

Fast algorithms for submodular maximization problems have a vast potential use in applicative settings, such as machine learning, social networks, and economics. Though fast algorithms were known for some special cases, only recently such algorithms were considered in the general case of maximizing a monotone submodular function subject to a matroid independence constraint. The known fast algorithm matches the best possible approximation guarantee, while trying to reduce the number of value oracle queries the algorithm performs. Our main result is a new algorithm for this general case that establishes a surprising trade-off between two seemingly unrelated quantities: the number of value oracle queries and the number of matroid independence queries performed by the algorithm. Specifically, one can decrease the former by increasing the latter, and vice versa, while maintaining the best possible approximation guarantee. Such a trade-off is very useful since various applications might incur significantly different costs in querying the value and matroid independence oracles. Furthermore, in case the rank of the matroid is O(nc), where n is the size of the ground set and c is an absolute constant smaller than 1, the total number of oracle queries our algorithm uses can be made to have a smaller magnitude compared to that needed by the current best known algorithm. We also provide even faster algorithms for the well-studied special cases of a cardinality constraint and a partition matroid independence constraint, both of which capture many real-world applications and have been widely studied both theoretically and in practice.
Increased sagittal vertical axis is associated with less effective control of acute pain following vertebroplasty
Authors: Kim Y-C. , Bok D. H. , Chang H-G. , Kim S. W. , Park M. S. , Oh J. K. , Kim J. , Kim T-H. 
Published: November 2016

Objectives Although vertebroplasty is very effective for relieving acute pain from an osteoporotic vertebral compression fracture, not all patients who undergo vertebroplasty receive the same degree of benefit from the procedure. In order to identify the ideal candidate for vertebroplasty, pre-operative prognostic demographic or clinico-radiological factors need to be identified. The objective of this study was to identify the pre-operative prognostic factors related to the effect of vertebroplasty on acute pain control using a cohort of surgically and non-surgically managed patients. Patients and Methods Patients with single-level acute osteoporotic vertebral compression fracture at thoracolumbar junction (T10 to L2) were followed. If the patients were not satisfied with acute pain reduction after a three-week conservative treatment, vertebroplasty was recommended. Pain assessment was carried out at the time of diagnosis, as well as three, four, six, and 12 weeks after the diagnosis. The effect of vertebroplasty, compared with conservative treatment, on back pain (visual analogue score, VAS) was analysed with the use of analysis-of-covariance models that adjusted for pre-operative VAS scores. Results A total of 342 patients finished the 12-week follow-up, and 120 patients underwent vertebroplasty (35.1%). The effect of vertebroplasty over conservative treatment was significant regardless of age, body mass index, medical comorbidity, previous fracture, pain duration, bone mineral density, degree of vertebral body compression, and canal encroachment. However, the effect of vertebroplasty was not significant at all time points in patients with increased sagittal vertical axis. Conclusions For single-level acute osteoporotic vertebral compression fractures, the effect of vertebroplasty was less favourable in patients with increased sagittal vertical axis (> 5 cm) possible due to aggravation of kyphotic stress from walking imbalance. Cite this article: Y-C. Kim, D. H. Bok, H-G. Chang, S. W. Kim, M. S. Park, J. K. Oh, J. Kim, T-H. Kim. Increased sagittal vertical axis is associated with less effective control of acute pain following vertebroplasty. Bone Joint Res 2016;5:544–551. DOI: 10.1302/2046-3758.511.BJR-2016-0135.R1.
Anti-leukemic activity of DNA methyltransferase inhibitor procaine targeted on human leukaemia cells
Authors: Borutinskaite Veronika , Bauraite-Akatova Justina , Navakauskiene Ruta 
Published: November 2016

AbstractChromatin remodeling in DNA is fundamental to gene expression, DNA replication and repair processes. Methylation of promoter regions of tumor-suppressor genes and histone deacetylation leads to gene silencing and transcriptionally repressive chromatin. For the past few decades DNA methylation agents became very attractive as the targets for cancer therapy. The purpose of this work was to examine the effects of DNMT inhibitor procaine on growth inhibition, apoptosis and differentiation of human leukaemia cells. The changes in expression of genes, proteins and histone modifications caused by procaine were evaluated under different treatments. We demonstrated that procaine arrests growth of human leukaemia cells and in combination with all-trans retinoic acid (ATRA) induces cancer cell differentiation. Procaine causes reduction of expression of DNA methyltransferases as well. The treatment of human leukaemia cells with procaine increase the expression of molecules associated with differentiation (CD11b, E-cadherin, G-CSF) and apoptosis (PPARγ). Moreover, the examined DNMT inhibitor enhances certain gene transcription activation via chromatin remodelling – the changes in histone H3K4(Me)3 and H3K9Ac/S10P modifications were detected. Our results suggest, that DNMT inhibitor – procaine, can be used for further investigations on epigenetic differentiation therapy of leukaemia cells especially when used in combination with retinoic acid.
Basic valency orientation in Homeric Greek
Authors: Sausa Eleonora 
Published: November 2016

AbstractIn a number of recent works, verbs and expressions encoding causative alternations have been regarded as a possible test for measuring the basic valency orientation of a language. This paper focuses on the basic orientation of valency in Homeric Greek. The test applied for determining this parameter is that proposed by Nichols et al. (2004, Transitivizing and detransitivizing languages.Linguistic Typology8(2). 149–211), focusing on 18 causative alternations. The investigation carried out in this paper shows that Homeric Greek belongs to the detransitivizing type, showing an active-middle alternation as the preferred pattern for expressing causative alternations. This study aims to enrich the typological literature on this topic and positions itself among other studies of valency orientation in ancient Indo-European languages, such as Old Hittite, Old Indo-Aryan, Proto-Germanic, and Proto-Slavic, which show transitivizing strategies along with voice alternation patterns.
The Mechanics of Omitted Variable Bias: Bias Amplification and Cancellation of Offsetting Biases
Authors: Steiner Peter M. , Kim Yongnam 
Published: November 2016

AbstractCausal inference with observational data frequently requires researchers to estimate treatment effects conditional on a set of observed covariates, hoping that they remove or at least reduce the confounding bias. Using a simple linear (regression) setting with two confounders – one observed (X), the other unobserved (U) – we demonstrate that conditioning on the observed confounderXdoes not necessarily imply that the confounding bias decreases, even ifXis highly correlated withU. That is, adjusting forXmay increase instead of reduce the omitted variable bias (OVB). Two phenomena can cause an increasing OVB: (i) bias amplification and (ii) cancellation of offsetting biases. Bias amplification occurs because conditioning onXamplifies any remaining bias due to the omitted confounderU. Cancellation of offsetting biases is an issue wheneverXandUinduce biases in opposite directions such that they perfectly or partially offset each other, in which case adjusting forXinadvertently cancels the bias-offsetting effect. In this article we discuss the conditions under which adjusting forXincreases OVB, and demonstrate that conditioning onXincreases the imbalance inU, which turnsUinto an even stronger confounder. We also show that conditioning on an unreliably measured confounder can remove more bias than the corresponding reliable measure. Practical implications for causal inference will be discussed.
A Member Selection Model of Collaboration New Product Development Teams Considering Knowledge and Collaboration
Authors: Su Jiafu , Yang Yu , Zhang Xuefeng 
Published: November 2016

AbstractMember selection to form an effective collaboration new product development (Co-NPD) team is crucial for a successful NPD. Existing researches on member selection mostly focus on the individual attributes of candidates. However, under the background of collaboration, knowledge complementarity and collaboration performance among candidates are important but overlooked. In this paper, we propose a multi-objective optimization model for member selection of a Co-NPD team, considering comprehensively the individual knowledge competence, knowledge complementarity, and collaboration performance. Then, to solve the model, an improved adaptive genetic algorithm (IAGA) is developed. Finally, a real case is provided to illustrate the application of the model, and the IAGA is implemented to select the desired team members for optimal team composition. Additionally, the standard generic algorithm and particle swarm optimization are used to compare with the IAGA to further verify the effectiveness of the IAGA.