bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives
Authors: Kumar Sunny , Ansari Aafreen , Basu Malini , Ghosh Sayani , Begam Sabana , Ghosh Mrinal K 
Published: September 2024

AbstractCarbon nanotubes (CNTs) have emerged as revolutionary tools, offering innovative approaches to both diagnostic and therapeutic challenges spanning various cancer types. CNTs serve as imaging agents for early detection through MRI, CT, and fluorescence. They provide precise results with biosensors detecting cancer biomarkers for rapid diagnosis. In cancer therapy, CNTs excel in targeted drug delivery, enhancing bioavailability and minimizing off‐target effects. Their prowess in photothermal therapy selectively eradicates cancer cells. Despite challenges, ongoing research highlights CNT's transformative potential, promising enhanced precision, efficacy, and personalized cancer care across diverse malignancies in future clinical practice.
Organic matter and nutrient content within putting green root zones in Tennessee
Authors: Kahiu Maureen M. , Woods Micah S. , Booth Jordan C. , Horvath Brandon J. , Brosnan James T. 
Published: September 2024

AbstractOrganic matter and soil nutrient accumulation within putting green root zones affects surface quality and performance. Research was conducted to explore differences in organic matter and nutrient content within creeping bentgrass (CBG; Agrostis stolonifera L.) and ultradwarf bermudagrass [UDBG; C. dactylon (L.) Pers. × C. transvaalensis Burtt‐Davy] putting greens. Sampling was conducted from January 30 to February 23, 2023, on 22 putting greens (11 CBG and 11 UDBG) in Tennessee. Forty cores (1.91‐cm diameter by 10‐cm depth) were randomly collected from each putting green and analyzed for total organic material (TOM; undisturbed cores) by profile depth (0–2 cm, 2–4 cm, and 4–6 cm), TOM throughout a 10‐cm core, soil organic matter (SOM; passed through sieve with 2 mm openings) throughout a 10‐cm core, and nutrient content. All organic matter measurements were determined via loss‐on‐ignition (LOI) testing, whereas nutrient content was determined by Mehlich‐3 extraction. LOI testing at 440°C resulted in greater TOM values than 360°C; however, values from both temperatures were closely related (R2 = 0.99). TOM values from UDBG greens were greater than those recorded on CBG at all profile depths. Greens established via no‐till conversion contained more TOM than those planted in a constructed sand‐matrix root zone. While TOM and SOM were associated (R2 = 0.62), removing verdure for SOM assessments reduced the amount of organic material in each sample by 38% and increased variability. Nutrient contents were lower than sufficiency level of available nutrients benchmarks but exceeded minimum levels for sustainable nutrition.
Southern California land surface temperature differences under different landscape composition
Authors: Schiavon Marco , Shiflett Sheri , Baird James H. , Geis Leo A. , Scudiero Elia 
Published: September 2024

AbstractIn the last decade, due to prolonged and persisting drought conditions, California initially restricted water for outdoor landscape irrigation, and subsequently offered turf removal rebates to homeowners. Nevertheless, the effects of turf removal on land surface temperature (LST) in the region have not been investigated. Temperature differences between artificial and natural turf were assessed over time across four counties in Southern California using MODIS/ASTER airborne simulator (MASTER) with a spatial resolution of 5–50 m. Moreover, airborne thermal imagery (submeter spatial resolution) was acquired over selected areas of the city of Riverside, CA, during the summers of 2018 and 2019, including neighborhoods with different income levels, and temperatures for natural turf, artificial turf, and xeriscape were recorded. Environmental and socioeconomic data were compared to the LST in different neighborhoods. Results showed that the LST difference between artificial and natural turf increases in Southern California moving from coastal region to inland. Airborne thermal imagery in Riverside confirmed that University of California artificial turf fields are irrigated during the summer to allow athletes to use the pitch. No correlation between socioeconomic factors and LST of turf and artificial turf fields (and paired differences) was found. On a city scale, natural turf lawns were consistently cooler than xeriscape and artificial turf lawns, closely mirroring mean air temperature. Socioeconomic factors do not describe LST in residential lawns, as warmest and coolest lawns regardless of vegetation are found evenly distributed among different income neighborhoods. Turfgrass removal for water conservation may have unforeseen environmental side effects.
WDR44 Loss‐of‐Function Promoter Deletion in a Male Newborn With a Ciliopathy Phenotype
Authors: Sneddon Tam P. , Gilmore Kelly L. , Xiong Mai , Weck Karen E. , Powell Bradford C. , Vora Neeta L. 
Published: September 2024

ABSTRACTGain‐of‐function variants in the WDR44 gene have recently been associated with an X‐linked ciliopathy‐related neurodevelopmental phenotype. Here, we report on a WDR44 loss‐of‐function (LOF) variant identified in the genome sequence from a male fetus enrolled in the Prenatal Genetic Diagnosis by Genomic Sequencing (PrenatalSEQ) multicenter study. The phenotype is consistent with the described X‐linked ciliopathy that includes developmental delay, microcephaly, congenital heart defects, kidney abnormalities, cryptorchidism, musculoskeletal abnormalities, craniofacial dysmorphism, and effusions. This is the first report of a WDR44 LOF variant in an affected individual with a prenatal presentation and supports LOF as a mechanism for the X‐linked WDR44 ciliopathy‐related phenotype.
Subjective cognitive decline and cognitive change among diverse middle‐aged and older Hispanic/Latino adults: Results from the Study of Latinos–Investigation of Neurocognitive Aging (SOL‐INCA)
Authors: Márquez Freddie , Tarraf Wassim , Kuwayama Sayaka , Valencia Deisha F. , Stickel Ariana M. , Morlett‐Paredes Alejandra , Guerrero Lourdes R. , Perreira Krista M. , Wassertheil‐Smoller Sylvia , Gonzalez Sara , Salazar Christian R. , Daviglus Martha L. , Gallo Linda C. , González Hector M. 
Published: September 2024

AbstractINTRODUCTIONThe potential utility of subjective cognitive decline (SCD) as an early risk marker of Alzheimer's disease and related dementias is under consideration. We examined associations between SCD and cognitive change among middle‐aged and older Hispanic/Latino adults living in the United States.METHODSThe short‐form Everyday Cognition Scale (ECog‐12) was assessed to generate global, executive function, and memory‐related SCD scores. We used survey generalized regressions to model the change in learning, memory, verbal fluency, executive function, and global cognitive performance over 7 years as a function of SCD (at Visit 2).RESULTSThe mean age was 56.37 ± 8.10 years at Visit 1 (n = 6225). Higher ECog‐12 was associated with greater decline in global cognitive performance (ECog‐12 global: B = –0.17, standard error [SE] = 0.02; ECog‐12 executive: B = –0.15, SE = 0.02; ECog‐12 memory: B = –0.14, SE = 0.02, p’s < 0.001).DISCUSSIONThese results support the link between subjective reports of cognitive decline and objectively measured 7‐year cognitive decline in community‐dwelling, middle‐aged, and older Hispanic/Latino adults.Highlights
We found that nearly two‐thirds of diverse middle‐aged and older Hispanics/Latinos reported cognitive concerns in a large and representative population study.
Self‐reported subjective experiences of cognitive decline reflect objective cognitive decline in US Hispanics/Latinos.
The relationship is stronger among men compared to women.
The relationship between subjective and objective changes to memory are stronger in those with cognitive concerns, and remain even in cognitively healthy individuals.
A Long‐Range Disordered RuO2 Catalyst for Highly Efficient Acidic Oxygen Evolution Electrocatalysis
Authors: Chen Guanzhen , Lu Ruihu , Ma Chao , Zhang Xuewen , Wang Ziyun , Xiong Yu , Han Yunhu 
Published: September 2024

AbstractNon‐iridium acid‐stabilized electrocatalysts for oxygen evolution reaction (OER) are crucial to reducing the cost of proton exchange membrane water electrolyzers (PEMWEs). Here, we report a strategy to modulate the stability of RuO2 by doping boron (B) atoms, leading to the preparation of a RuO2 catalyst with long‐range disorder (LD‐B/RuO2). The structure of long‐range disorder endowed LD‐B/RuO2 with a low overpotential of 175 mV and an ultra‐long stability, which can maintain OER for about 1.6 months at 10 mA cm−2 current density in 0.5 M H2SO4 with almost invariable performance. More importantly, a PEM electrolyzer using LD‐B/RuO2 as the anode demonstrated excellent performance, reaching 1000 mA cm−2 at 1.63 V with durability exceeding 300 h at 250 mA cm−2 current density. The introduction of B atoms induced the formation of a long‐range disordered structure and symmetry‐breaking B−Ru−O motifs, which enabled the catalyst structure to a certain toughness while simultaneously inducing the redistribution of electrons on the active center Ru, which jointly promoted and guaranteed the activity and long‐term stability of LD‐B/RuO2. This study provides a strategy to prepare long‐range disordered RuO2 acidic OER catalysts with high stability using B‐doping to perturb crystallinity, which opens potential possibilities for non‐iridium‐based PEMWE applications.
Full‐Spectrum Light‐Harvesting Solar Thermal Electrocatalyst Boosts Oxygen Evolution
Authors: Xu Mingxia , Bing Qiming , Tu Yunchuan , Zhang Yunlong , Zhang Mo , Cai Yafeng , Li Jinlei , Meng Xianguang , Zhu Jia , Yu Liang , Deng Dehui 
Published: September 2024

AbstractEnabling high‐efficiency solar thermal conversion (STC) at catalytic active site is critical but challenging for harnessing solar energy to boost catalytic reactions. Herein, we report the direct integration of full‐spectrum STC and high electrocatalytic oxygen evolution activity by fabricating a hierarchical nanocage architecture composed of graphene‐encapsulated CoNi nanoparticle. This catalyst exhibits a near‐complete 98 % absorptivity of solar spectrum and a high STC efficiency of 97 %, which is superior than previous solar thermal catalytic materials. It delivers a remarkable potential decrease of over 240 mV at various current densities for electrocatalytic oxygen evolution under solar illumination, which is practically unachievable via traditionally heating the system. The high‐efficiency STC is enabled by a synergy between the regulated electronic structure of graphene via CoNi‐carbon interaction and the multiple absorption of lights by the light‐trapping nanocage. Theoretical calculations suggest that high temperature‐induced vibrational free energy gain promotes the potential‐limiting *O to *OOH step, which decreases the overpotential for oxygen evolution.
Telehealth coaching in Project ImPACT indirectly affects children's expressive language ability through parent intervention strategy use and child intentional communication: An RCT
Authors: Ingersoll Brooke , Frost Kyle M. , Straiton Diondra , Ramos Anamiguel Pomales , Casagrande Karis 
Published: September 2024

AbstractParent‐mediated, naturalistic developmental behavioral interventions (NDBIs) are a promising approach for supporting social communication development in young autistic children. This study examined the effect of telehealth delivery of a parent‐mediated NDBI, Project ImPACT, on children's expressive language ability using a randomized control trial with intent‐to‐treat analysis. Sixty‐four young autistic children and their primary caregiver were matched on age and developmental quotient and randomly assigned to receive 6 months of therapist‐assisted Project ImPACT (i.e., telehealth coaching), self‐directed Project ImPACT, or an active control. Parent–child interactions were recorded at intake and immediately post‐treatment, and the children's expressive language skills were assessed at intake and a 9‐month follow‐up using standardized measures. Although there was no total effect of treatment group assignment on child outcomes, a serial mediation analysis revealed that therapist‐assisted ImPACT had an indirect effect on children's expressive language ability at follow‐up through their parents' use of the intervention strategies and their intentional communication immediately post‐treatment. Findings support Project ImPACT's program theory and highlight the importance of coaching in achieving positive outcomes when delivered via telehealth.
Transforming text to music using artificial intelligence improves the frontal lobe function of normal older adults
Authors: Satoh Masayuki , Inoue Jun , Ogawa Jun‐ichi , Tabei Ken‐ichi , Kamikawa Chiaki , Abe Makiko , Yoshizawa Ayaka , Kitagawa Gyo , Ota Yosinori 
Published: September 2024

AbstractIntroductionRecent advances in artificial intelligence (AI) have been substantial. We investigated the effectiveness of an online meeting in which normal older adults (otokai) used a music‐generative AI that transforms text to music (Music Trinity Generative Algorithm‐Human Refined [MusicTGA‐HR]).MethodsOne hundred eighteen community‐dwelling, cognitively normal older adults were recruited through the internet (64 men, 54 women; mean age: 69.4 ± 4.4 years). Using MusicTGA‐HR, the participants chose music that they thought was the most suitable to a given theme. We established 11 classes of 7–10 members and one instructor each. Each class held an online meeting once a week, and each participant presented the music they chose. The other participants and the instructor then commented on the music. Neuropsychological assessments were performed before and after the intervention for 6 months, and the results before and after the intervention were statistically analyzed.ResultsThe category and letter word fluencies (WFs) were significantly improved (category WF: p = .003; letter WF: p = .036), and the time of the Trail‐Making Test‐B was also significantly shortened (p = .039). The Brain Assessment, an online cognitive test we developed, showed significant improvement in the memory of numbers (p < .001).ConclusionThe online meeting of the otokai, which used music‐generative AI, improved the frontal lobe function and memory of independent normal older adults.
Hypoperfusion of periaqueductal gray as an imaging biomarker in chronic migraine beyond diagnosis: A 3D pseudocontinuous arterial spin labeling MR imaging
Authors: Huang Pan , Wu Mei , Liu Mengqi , Li Xin , Jiang Yujiao , Chen Zhiye 
Published: September 2024

AbstractBackgroundThe periaqueductal gray (PAG) is at the center of a powerful descending antinociceptive neuronal network, and is a key node in the descending pain regulatory system of pain. However, less is known about the altered perfusion of PAG in chronic migraine (CM).AimTo measure the perfusion of PAG matter, an important structure in pain modulation, in CM with magnetic resonance (MR) perfusion without contrast administration.MethodsThree‐dimensional pseudocontinuous arterial spin labeling (3D‐PCASL) and brain structure imaging were performed in 13 patients with CM and 15 normal subjects. The inverse deformation field generated by brain structure image segmentation was applied to the midbrain PAG template to generate individualized PAG. Then the perfusion value of the PAG area of the midbrain was extracted based on the individual PAG mask.ResultsCerebral blood flow (CBF) value of PAG in CM patients (47.98 ± 8.38 mL/100 mg min) was significantly lower than that of the control group (59.87 ± 14.24 mL/100 mg min). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve was 0.77 (95% confidence interval [CI], 0.60, 0.94), and the cutoff value for the diagnosis of CM was 54.83 mL/100 mg min with a sensitivity 84.60% and a specificity 60%.ConclusionImaging evidence of the impaired pain conduction pathway in CM may be related with the decreased perfusion in the PAG, which could be considered as an imaging biomarker for the diagnosis and therapy evaluation.
Volumetric analysis of the hypothalamic subunits in obstructive sleep apnea
Authors: Mohammadi Mahdi , Oghabian Mohammad Ali , Ghaderi Sadegh , Jalali Maryam , Samadi Shahram 
Published: September 2024

AbstractBackgroundObstructive sleep apnea (OSA) is a prevalent sleep disorder that is associated with structural brain damage and cognitive impairment. The hypothalamus plays a crucial role in regulating sleep and wakefulness. We aimed to evaluate hypothalamic subunit volumes in patients with OSA.MethodsWe enrolled 30 participants (15 patients with OSA and 15 healthy controls (HC)). Patients with OSA underwent complete overnight polysomnography (PSG) examination. All the participants underwent MRI. The hypothalamic subunit volumes were calculated using a segmentation technique that trained a 3D convolutional neural network.ResultsAlthough hypothalamus subunit volumes were comparable between the HC and OSA groups (lowest p = .395), significant negative correlations were found in OSA patients between BMI and whole left hypothalamus volume (R = –0.654, p = .008), as well as between BMI and left posterior volume (R = –0.556, p = .032). Furthermore, significant positive correlations were found between ESS and right anterior inferior volume (R = 0.548, p = .042), minimum SpO2 and the whole left hypothalamus (R = 0.551, p = .033), left tubular inferior volumes (R = 0.596, p = .019), and between the percentage of REM stage and left anterior inferior volume (R = 0.584, p = .022).ConclusionsWhile there were no notable differences in the hypothalamic subunit volumes between the OSA and HC groups, several important correlations were identified in the OSA group. These relationships suggest that factors related to sleep apnea severity could affect hypothalamic structure in patients.
Strategic resilience nexus: Connecting pioneering and sustainability orientations
Authors: Parra‐Requena Gloria , García‐Villaverde Pedro M. , Ruiz‐Ortega María José , Córcoles‐Muñoz Mateo M. 
Published: September 2024

AbstractThis work analyzes, under a strategic approach, the role of organizational resilience (OR) in connecting pioneering orientation (PO) and sustainability orientation (SO), thus filling a significant and unexplored gap in the literature. The empirical study was conducted on a sample of 223 companies in the cultural tourism industry in Spain. The results show a total mediating effect of OR in the relationship between PO and SO in its economic, environmental, and social dimensions and a partial effect in the case of the cultural dimension. The study highlights the U‐shaped curvilinear relationship between PO and OR, reflecting a brake on the growth of OR when companies have a strong tendency to enter the market early. Companies should adopt the role of early followers to strengthen resilience and achieve a strong strategic commitment to sustainability.
A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response
Authors: Richter Clémentine , Latta Lorenz , Harig Daria , Carius Patrick , Stucki Janick D. , Hobi Nina , Hugi Andreas , Schumacher Paul , Krebs Tobias , Gamrekeli Alexander , Stöckle Felix , Urbschat Klaus , Montalvo Galia , Lautenschläger Franziska , Loretz Brigitta , Hidalgo Alberto , Schneider‐Daum Nicole , Lehr Claus‐Michael 
Published: September 2024

AbstractThis study describes a complex human in vitro model for evaluating anti‐inflammatory drug response in the alveoli that may contribute to the reduction of animal testing in the pre‐clinical stage of drug development. The model is based on the human alveolar epithelial cell line Arlo co‐cultured with macrophages differentiated from the THP‐1 cell line, creating a physiological biological microenvironment. To mimic the three‐dimensional architecture and dynamic expansion and relaxation of the air‐blood‐barrier, they are grown on a stretchable microphysiological lung‐on‐chip. For validating the in vitro model, three different protocols have been developed to demonstrate the clinically established anti‐inflammatory effect of glucocorticoids to reduce certain inflammatory markers after different pro‐inflammatory stimuli: (1) an inflammation caused by bacterial LPS (lipopolysaccharides) to simulate an LPS‐induced acute lung injury measured best with cytokine IL‐6 release; (2) an inflammation caused by LPS at ALI (air‐liquid interface) to investigate aerosolized anti‐inflammatory treatment, measured with chemokine IL‐8 release; and (3) an inflammation with a combination of human inflammatory cytokines TNFα and IFNγ to simulate a critical cytokine storm leading to epithelial barrier disruption, where the eventual weakening or protection of the epithelial barrier can be measured. In all cases, the presence of macrophages appeared to be crucial to mediating inflammatory changes in the alveolar epithelium. LPS induction led to inflammatory changes independently of stretch conditions. Dynamic stretch, emulating breathing‐like mechanics, was essential for in vitro modeling of the clinically relevant outcome of epithelial barrier disruption upon TNFα/IFNγ‐induced inflammation.
PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2− breast cancer
Authors: Terán Eduardo , Lozano Rebeca , Rodríguez César A. , Abad Mar , Figuero Luis , Muñoz José Antonio , Cigarral Belén , Rodrígues Aline , Sancho Magdalena , Gómez M. Asunción , Morchón Daniel , Montero Juan Carlos , Sayagués José María , Ludeña M. Dolores , Fonseca Emilio 
Published: September 2024

AbstractIntroductionHotspots (HS) mutations in the PIK3CA gene may lead to poorer oncological outcomes and endocrine resistance in advanced breast cancer (BC), but their prognostic role in early‐stage disease remains controversial. The overall agreement within plasma and tissue methods has not been well explored. Our aim was to correlate tissue and plasma approaches and to analyze the prognostic impact of PIK3CA mutations (PIK3CAm) in HR+/HER2− BC.MethodsA retrospective and unicentric analysis of PIK3CA mutational status in tissue and plasma samples by Cobas®PIK3CA Mutation Kit in patients with HR+/HER2− BC.ResultsWe analyzed 225 samples from 161 patients with luminal BC. PIK3CA mutations were identified in 62 patients (38.5%), of which 39.6% were found in tissue and 11.8% in plasma. In advanced disease, plasma and tissue correlation rate was performed in 64 cases, with an overall agreement of 70.3%. Eighty patients were treated with CDK4/6 inhibitors + endocrine therapy. We observed a moderately worse progression‐free survival (PFS) in PIK3CAm versus wild‐type (WT) (24 m vs. 30 m; HR = 1.39, p = 0.26). A subanalysis was carried out based on exons 9 and 20, which showed a statistically poorer PFS in PIK3CAm exon 9 versus 20 population (9.7 m vs. 30.3 m; HR = 2.84; p = 0.024). Furthermore, detection of PIK3CAm in plasma was linked to a worse PFS vs PIK3CAm detection just in tissue (12.4 vs. 29.3; HR = 2.4; p = 0.08).ConclusionsOur findings suggest the PIK3CA evaluation in tissue as the diagnostic method of choice, however, additional investigations are required to improve the role of liquid biopsy in the PIK3CA assessment. PIK3CAm show worse outcomes in advanced luminal BC, especially in exon 9 mutation carriers, despite visceral involvement, prior exposure to endocrine therapy or detection of PIK3CAm in plasma, with an unclear prognosis in early‐stage disease. Nonetheless, this should be validated in a prospective cohort study.