bluuebunny/crossref_metadata_2025_split huggingface dataset:
Animal‐cell culture media: History, characteristics, and current issues
Authors: Yao Tatsuma , Asayama Yuta 
Published: March 2017

AbstractBackgroundCell culture technology has spread prolifically within a century, a variety of culture media has been designed. This review goes through the history, characteristics and current issues of animal‐cell culture media.MethodsA literature search was performed on PubMed and Google Scholar between 1880 and May 2016 using appropriate keywords.ResultsAt the dawn of cell culture technology, the major components of media were naturally derived products such as serum. The field then gradually shifted to the use of chemical‐based synthetic media because naturally derived ingredients have their disadvantages such as large batch‐to‐batch variation. Today, industrially important cells can be cultured in synthetic media. Nevertheless, the combinations and concentrations of the components in these media remain to be optimized. In addition, serum‐containing media are still in general use in the field of basic research. In the fields of assisted reproductive technologies and regenerative medicine, some of the medium components are naturally derived in nearly all instances.ConclusionsFurther improvements of culture media are desirable, which will certainly contribute to a reduction in the experimental variation, enhance productivity among biopharmaceuticals, improve treatment outcomes of assisted reproductive technologies, and facilitate implementation and popularization of regenerative medicine.
Foreshadowing as Impression Management: Illuminating the Path for Security Analysts
Authors: Busenbark John R. , Lange Donald , Certo S. Trevis 
Published: March 2017

Research summary: Managers can disclose information to security analysts as a form of impression management, but doing so is problematic because competitors can use that same information at the expense of the firm. We identify an impression management technique we call foreshadowing, which refers to hinting about future potential strategic activity. Foreshadowing provides information of value to analysts that can influence their evaluations of a firm, but not so much information as to put the firm at a competitive disadvantage. We hypothesize and find that managers who foreshadow acquisition announcements receive fewer analyst downgrades following the announcements, especially when there is more analyst uncertainty about the firm. We also hypothesize and find that analysts' responses to foreshadowing positively influence the likelihood that managers eventually acquire other firms.Managerial summary: Security analysts are often suspicious when firms announce acquisitions as those announcements are cumbersome to analyze on short notice and raise questions about managerial motivations that might not represent the best interests of the firm. We find that managers can improve analyst reactions to acquisition announcements by disclosing some information of value to analysts—specifically by hinting that an acquisition could occur in the future. We refer to such hints as foreshadowing. Foreshadowing entails giving analysts information to reduce their suspicions and facilitate their analyses, but not so much information as to degrade the firm's competitive information advantage over other firms. Foreshadowing also allows managers the option to reconsider actually executing the acquisition if analysts respond negatively to its possibility. Copyright © 2017 John Wiley & Sons, Ltd.
Towards a multi‐element silicon drift detector system for fluorescence spectroscopy in the soft X‐ray regime
Authors: Bufon Jernej , Gianoncelli Alessandra , Ahangarianabhari Mahdi , Altissimo Matteo , Bellutti Pierluigi , Bertuccio Giuseppe , Borghes Roberto , Carrato Sergio , Cautero Giuseppe , Cicuttin Andres , Crespo Maria Liz , Fabiani Sergio , Gandola Massimo , Giacomini Gabriele , Giuressi Dario , Kourousias George , Menk Ralf Hendrik , Picciotto Antonino , Piemonte Claudio , Rachevski Alexandre , Rashevskaya Irina , Schillani Stefano , Stolfa Andrea , Vacchi Andrea , Zampa Gianluigi , Zampa Nicola , Zorzi Nicola 
Published: March 2017

In spite of the constant technological improvements in the field of detector development, X‐ray fluorescence (XRF) in the soft X‐ray regime remains a challenge. The low intrinsic fluorescence yield for energies below 2 keV indeed renders the applicability of low‐energy XRF still difficult.Here, we report on a new multi‐element multi‐tile detection system currently under development, designed to be integrated into a soft X‐ray microscopy end station. The system will be installed at the TwinMic beamline of Elettra synchrotron (Trieste, Italy) in order to increase the detected count rate by up to an order of magnitude. The new architecture is very versatile and can be adapted to any XRF experimental setup.Even though the first results of the previous version of such a multi‐element system were encouraging, several issues still needed to be addressed. The system described here represents a further step in the detector evolution. It is based on four trapezoidal‐shaped monolithic silicon drift detector tiles (matrices) with six hexagonal elements each equipped with a custom ultra‐low noise application‐specific integrated circuit readout. The whole signal processing chain has been improved leading to an overall increase in performances, namely, in terms of energy resolution and acquisition rates.The design and development of this new detection system will be described, and recent results obtained at the TwinMic beamline at Elettra will be presented. Future perspectives and improvements will also be discussed. Copyright © 2017 John Wiley & Sons, Ltd.
Refining the boundaries of the classical de Sitter landscape
Authors: Andriot David , Blåbäck Johan 
Published: March 2017

Abstract
We derive highly constraining no-go theorems for classical de Sitter backgrounds of string theory, with parallel sources; this should impact the embedding of cosmological models. We study ten-dimensional vacua of type II supergravities with parallel and backreacted orientifold O
p
-planes and D
p
-branes, on four-dimensional de Sitter spacetime times a compact manifold. Vacua for p = 3, 7 or 8 are completely excluded, and we obtain tight constraints for p = 4, 5, 6. This is achieved through the derivation of an enlightening expression for the four-dimensional Ricci scalar. Further interesting expressions and no-go theorems are obtained. The paper is self-contained so technical aspects, including conventions, might be of more general interest.
Efficacy and safety of golimumab 52-week maintenance therapy in Japanese patients with moderate to severely active ulcerative colitis: a phase 3, double-blind, randomized, placebo-controlled study-(PURSUIT-J study)
Authors: Hibi Toshifumi , Imai Yuya , Senoo Asako , Ohta Kentaro , Ukyo Yoshifumi 
Published: March 2017

Abstract
Background
The global phase 3 studies of golimumab [PURSUIT-SC and PURSUIT-maintenance (M)], an anti-tumor necrosis factor-α (anti-TNFα) antibody, have demonstrated clinical efficacy and safety as induction and maintenance therapies in patients with moderate to severely active ulcerative colitis (UC). This study aimed to evaluate the efficacy and safety of golimumab as maintenance therapy in the Japanese population.

Methods
In this phase 3, double-blind (DB), placebo-controlled, parallel group, randomized withdrawal study, 144 Japanese patients with moderately to severely active UC received golimumab doses of 200 mg (at week 0) and 100 mg (at week 2) subcutaneously during the 6-week open-label induction phase. Patients who responded to golimumab induction therapy entered the DB maintenance (M) phase and were randomized (1:1) to receive 100 mg of golimumab subcutaneous injection (SC) or placebo every 4 weeks for 52 weeks. The primary endpoint was clinical response through M-week 54; secondary endpoints included clinical remission and mucosal healing at M-week 30 and 54.

Results
Among induction responders, more patients on golimumab treatment (56.3%) maintained clinical response through M-week 54 versus the placebo group (19.4%). At both M-week 30 and 54, 50% golimumab-treated patients achieved clinical remission versus the placebo group (6.5%) and a higher proportion of patients on golimumab (59.4%) experienced mucosal healing than the placebo group (16.1%). Incidence of treatment-emergent adverse events was 96.9% in the golimumab group and 71% in the placebo group. Overall, the efficacy and safety results in this study were comparable with those observed in global studies.

Conclusions
Golimumab SC treatment maintained clinical efficacy through week 54 among induction responders, and no new safety signals were observed in the patients with moderate to severely active UC.
Clinical Trial Registration: The study is registered at ClinicalTrials.gov NCT01863771.
The use of periodic matrices to model the population dynamics of the long‐lived semelparous Furcraea parmentieri (Asparagaceae) in a temperate forest in central Mexico
Authors: Hernández‐Pedrero Román , Valverde Teresa 
Published: March 2017

AbstractFurcraea parmentieri (Roezl ex Ortgies) García‐Mend. is a long‐lived, semelparous threatened species with a restricted geographic distribution. We studied the demography of this species in southwest of Mexico City using periodic matrices. We followed the fate of 404 individuals (in 2006–2007) and performed seed germination and seedling establishment experiments in the field (in 2007–2008) to estimate survival, growth and reproduction probabilities of individuals in eight size categories, according to plant height. Population structure was characterized by a high number of saplings, as well as medium and large plants. We built three annual matrices that described the demography in different phases of the population cycle: regular years (RG) characterized by low fecundity and low adult mortality; mast‐seeding years (MS) with low seedling emergence and high adult mortality (related to semelparity); and post mast‐seeding years (PS) with a high emergence of seedlings and bulbils. Periodic matrices were built simulating three scenarios, which consisted of mast‐seeding events occurring every 5, 10, or 15 years. Finite population growth rates (λ) were 1.03 (RG year), 0.99 (MS year), and 1.25 (PS year). The long term population growth rate values projected over a 90 year period (estimated on an annual basis) were higher as the frequency of mast‐seeding events increased. We estimated that individuals reproduce at an age of 60–90 years and that most new recruits originate via sexual reproduction. Although the population has a potential for growth, its persistence may be threatened due to land use change.
Influence of weather and phenotypic characteristics on pregnancy rates of female roe deer in central Italy
Authors: Lombardini Marco , Varuzza Paolo , Meriggi Alberto 
Published: March 2017

AbstractIn many ungulates, female fecundity is influenced by weather, population density and body condition. Based on a six‐year survey of the reproductive tracts of adult female roe deer (Capreolus capreolus) harvested in the province of Pisa (Tuscany, central Italy), we evaluated the influence of weather, population density and individual characteristics on pregnancy rates. Eighty‐five percent of females were pregnant, with a median litter size of two (range one—three). We found that pregnancy rate was positively correlated with summer rainfall and body mass of females, whereas early‐winter conditions, spring rainfall, the age of females and density‐dependent factors did not appear to influence pregnancy rate. These results reflect the particular seasonal variation in the abundance and quality of resources in Mediterranean habitats and show that heavier females (high‐quality mothers) are more productive than lighter females.
Longitudinal relationships of sleep and inhibitory control deficits to early adolescent cigarette and alcohol use
Authors: Warren Christopher M. , Riggs Nathaniel R. , Pentz Mary Ann 
Published: March 2017

ABSTRACTResearch in older adolescents suggests insufficient sleep may increase substance use initiation risk. This study tested whether sleep duration and dysregulation of sleep‐wake patterns in late‐elementary school youth were prospectively associated with cigarette and alcohol use initiation and how sleep‐related changes in inhibitory control mediate these relationships. Average sleep duration at 4th grade predicted 6th grade cigarette but not alcohol use, however indirect effects were identified through 5th grade inhibitory control to both cigarette and alcohol use. Indirect effects were also identified through inhibitory control for relationships between 4th grade weekend bed‐time delay and 6th grade cigarette or alcohol use, and for relationships between 4th grade weekend wake‐time delay and 6th grade cigarette or alcohol use. Reductions in nightly sleep increased risk of cigarette use. Findings suggest a pathway linking both reduced sleep duration and greater weekend shifting of sleep patterns to future substance use through sleep‐related inhibitory control deficits.
Clinical Issues‐April 2017
Authors: Wood Amber 
Published: March 2017

This MonthPatient involvement in hand hygieneKey words: patient engagement, hand hygiene, hand washing stations, hand hygiene promotion.Alcohol‐based surgical hand rubs in the ORKey words: hand hygiene, hand rub, dispenser.Personal hand hygiene dispensersKey words: hand hygiene, hand rub, hand rub dispenser, personal dispenser.Hand soapKey words: soap, hand hygiene, hand wash, plain soap, triclosan.Disposal of water used for plaster application in scrub sinksKey words: plaster, pour, sink, scrub sink.Multiple hand hygiene indicationsKey words: hand hygiene, hand wash, hand rub.
Reid on the Autonomy of Ethics: From Active Power to Moral Nonnaturalism
Authors: CUNEO TERENCE , HARP RANDALL 
Published: March 2017

ABSTRACT:Thomas Reid has the unusual distinction of arriving at a metaethical position very much like G. E. Moore's via a route very similar to that employed by the Kantians. That is, Reid embraces a version of nonnaturalist moral realism by appeal not to open question-style considerations but to a particular account of agency. In this essay, we reconstruct Reid's agency-centered argument for his constitutivist version of moral nonnaturalism, highlighting its commitments. Having presented Reid's argument, we close by considering a prominent contemporary Kantian view, namely, Christine Korsgaard's, and identifying where, despite their common commitments, Reid and Korsgaard part company. The comparison, we suggest, is instructive because it allows us to see more clearly why the link between agency-centered approaches to ethical theorizing and nonrealist, constitutivist views of morality, such as Korsgaard's, is deeply contingent.
Helicobacter pylorias an oncogenic pathogen, revisited
Authors: Miftahussurur Muhammad , Yamaoka Yoshio , Graham David Y. 
Published: March 2017

Gastric cancer is an inflammation-associated malignancy aetiologically related to infection with the bacterium,Helicobacter pylori, which is considered a necessary but insufficient cause. Unless treated,H. pyloricauses life-long acute and chronic gastric inflammation resulting in progressive gastric mucosal damage that may result in gastric cancer. The rate of progression from superficial gastritis, to an atrophic metaplastic mucosa, and ultimately to cancer relates to the virulence of the infectingH. pylorias well as host and environmental factors.H. pylorivirulence is a reflection of its propensity to cause severe gastric inflammation. Both mucosal inflammation andH. pylorican cause host genomic instability, including dysregulation of DNA mismatch repair, stimulation of expression of activation-induced cytidine deaminase, abnormal DNA methylation and dysregulation of micro RNAs, which may result in an accumulation of mutations and loss of normal regulation of cell growth. The difference in cancer risk between the most and least virulentH. pyloristrain is only approximately 2-fold. Overall, none of the putative virulence factors identified to date have proved to be disease-specific. The presence, severity, extent and duration of inflammation appear to be the most important factors and current evidence suggests that any host, environmental or bacterial factor that reliably enhances the inflammatory response to theH. pyloriinfection increases the risk of gastric cancer.
Pattern of impairments and late diagnosis of autism spectrum disorder among a sub-Saharan African clinical population of children in Nigeria
Authors: Bello-Mojeed M. A. , Omigbodun O. O. , Bakare M. O. , Adewuya A. O. 
Published: March 2017

Background.Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders. Studies conducted among Africans living outside the continent indicate that African children are more likely than Caucasian children to have a late diagnosis of ASD. There is a dearth of information on this topic among children with ASD living in Africa.Methods.To determine the pattern of impairments and age at diagnosis in ASD, sixty Nigerian children with a diagnosis of ASD were recruited from a neurodevelopmental clinic. DSM-V criteria were used to make a diagnosis of ASD, while a symptom checklist for ASD was used to determine the pattern of impairments in ASD.Results.Ages of the children ranged from 2 to 17 years with a mean age of 9.45 ± 4.33 years with the majority of them (75%) being 12 years or younger. All the children (100%) with ASD exhibited poor eye contact, difficulty in mixing with other children and inability to consistently respond to his/her name. More than a half of them (55%) lack verbal communication. Impairments that were uncommon are in the areas of object attachment (20.0%), odd postures (26.7%) and inappropriate facial expression (30.0%). Mean age at the observation of ASD features was 17.0 ± 6.7 months. Mean age at diagnosis of ASD was 9.00 ± 4.30 years. The mean time lag from a parental concern of ASD features to seeking specialist care was 85 months and to diagnosis was 91 months.Conclusions.Core symptoms/impairments of ASD are present in Nigerian children but a late diagnosis is common.
The Banana and Peanut Archive of Ghana
Authors: Ntewusu Samuel Aniegye 
Published: March 2017

Abstract:This paper discusses an emerging problem in Ghana and its implications for Ghana’s archives and historical writing. It explains why some important documents intended for state and institutional archives eventually find their way back into public circulation – some have even been used to wrap roasted food! The paper provides methodological insights to historians and researchers and perhaps warnings too that they should consider alternative sources to archives in their quest for information on Ghana; for after all some researchers on Ghana have come across some amazing documents and historical evidence among the food vendors on Ghana’s streets.
DEFINABLE AND INVARIANT TYPES IN ENRICHMENTS OF NIP THEORIES
Authors: RIDEAU SILVAIN , SIMON PIERRE 
Published: March 2017

AbstractLet T be an NIP ${\cal L}$-theory and $\mathop T\limits^\~ $ be an enrichment. We give a sufficient condition on $\mathop T\limits^\~$ for the underlying ${\cal L}$-type of any definable (respectively invariant) type over a model of $\mathop T\limits^\~$ to be definable (respectively invariant). These results are then applied to Scanlon’s model completion of valued differential fields.
MEASURABLE PERFECT MATCHINGS FOR ACYCLIC LOCALLY COUNTABLE BOREL GRAPHS
Authors: CONLEY CLINTON T. , MILLER BENJAMIN D. 
Published: March 2017

AbstractWe characterize the structural impediments to the existence of Borel perfect matchings for acyclic locally countable Borel graphs admitting a Borel selection of finitely many ends from their connected components. In particular, this yields the existence of Borel matchings for such graphs of degree at least three. As a corollary, it follows that acyclic locally countable Borel graphs of degree at least three generating μ-hyperfinite equivalence relations admit μ-measurable matchings. We establish the analogous result for Baire measurable matchings in the locally finite case, and provide a counterexample in the locally countable case.
Acanthocotyle gurgesiella n. sp. (Monogenea: Acanthocotylidae) from the deep-sea skate Gurgesiella furvescens (Rajidae) in the south-eastern Pacific
Authors: Ñacari L.A. , Sepulveda F.A. , Escribano R. , Oliva M.E. 
Published: March 2017

AbstractLittle is known about the diversity of parasites of the deep-sea fish of the world's oceans. Here, a new species of monogenean parasite of the deep-sea skate Gurgesiella furvescens is described. Specimens of parasites were obtained from the skin of two specimens of the dusky finless skate, G. furvescens (Rajidae), in the vicinity of Valparaiso (33°S, 72°W), central Chile, from midwater trawl fishing at depths of 350–450 m. Both morphological and molecular analyses were conducted to provide a full description of the new species, named Acanthocotyle gurgesiella. For the molecular analyses, nuclear large subunit (LSU) rDNA and the mitochondrial gene cytochrome c oxidase 1 (COI) were used. From the morphological analysis and a comparison with the known species of the genus, A. gurgesiella can be identified by a combination of morphological characteristics, including the number of testes, number of radial rows of sclerites in the pseudohaptor, aperture of the genital pore and shape of the vitelline follicles. The results from the DNA analysis indicated that A. gurgesiella has a genetic divergence of 3.2–3.7% (LSU rDNA gene) from A. urolophi, the only congener species for which molecular data are available.
Observer-based two-time scale robust control of free-flying flexible-joint space manipulators with external disturbances
Authors: Yu Xiaoyan , Chen Li 
Published: March 2017

SUMMARYObserver-based two-time scale robust control is proposed for free-flying flexible-joint space manipulators with unknown payload parameters and bounded disturbances. The dynamic equations of a free-flying space manipulator with two flexible revolute joints were derived by the momentum conservation law and the Lagrange equations. A flexibility compensator was introduced to make the equivalent joint stiffness large enough, which made traditional singular perturbation approach applicable. Then, a singular perturbation model was formulated and a reduced-order controller is proposed. This controller consisted of a slow sub-controller and a fast flexible-joint sub-controller. To the slow subsystem, a sliding observer based robust slow sub-controller was proposed. By optimal linear quadratic regulator method, the fast sub-controller was designed with the estimated velocity by linear observer. This fast sub-controller could stabilize the fast subsystem around the equilibrium trajectory created by the slow subsystem under the effect of the slow control. Finally the numerical simulations were carried out, which showed that elastic joint vibrations had been stabilized effectively and good tracking performances had been achieved.
Connecting interacting galaxies with manifolds
Authors: Romero-Gomez M. , Athanassoula E. 
Published: March 2017

AbstractIt is well known that the interaction between two disk galaxies generates tidal spiral arms and a connection in the form of a bridge. Here we address the question of the formation of tidal arms and bridges from a dynamical point of view. We model the bridges and tails observed in interacting galaxies using the invariant manifolds associated to the Lyapunov orbits of the Lagrangian points of the galactic system, when the two galaxies are considered as two point masses in a circular orbit.
Interacting galaxies in the NGC 697 group of galaxies
Authors: Vennik Jaan 
Published: March 2017

AbstractWe studied the morphology of two brightest members of the nearby NGC 697 group of galaxies, and found evidence of satellite accretion onto the primary galaxy NGC 697 of the group as well as outer and inner irregularities of the only early-type galaxy NGC 680 of the group, which are probably shaped by recent dry merging event(s).