bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized Double‐Blind Controlled Trial of Intravenous Meloxicam in the Treatment of Pain Following Dental Impaction Surgery
Authors: Christensen Steven E. , Cooper Stephen A. , Mack Randall J. , McCallum Stewart W. , Du Wei , Freyer Alex 
Published: January 2018

AbstractThis randomized, controlled phase 2 study was conducted to evaluate the analgesic efficacy, safety, and tolerability of single intravenous (IV) doses of 15 mg, 30 mg, and 60 mg meloxicam compared with oral ibuprofen 400 mg and placebo after dental impaction surgery. The primary efficacy end point was the sum of time‐weighted pain intensity differences for 0‐24 hours postdose. Among 230 evaluable subjects, meloxicam IV 60 mg produced the greatest reduction in pain, followed by the 30‐mg and 15‐mg doses. Statistically significant differences in summed pain intensity differences over 24 hours were demonstrated for each active‐treatment group vs placebo (favoring active treatment) and for meloxicam IV 30 mg and 60 mg vs ibuprofen 400 mg (favoring meloxicam IV). Moreover, there was a statistically significant dose response for meloxicam IV 15 mg to 60 mg. The onset of action for meloxicam IV was rapid and sustained; significant differences in pain intensity differences were detected as early as 10 minutes postdose and lasted through the 24‐hour postdose period. Subjects in the meloxicam IV groups were more likely than placebo recipients to achieve perceptible and meaningful pain relief and were less likely to use rescue medication. Patient‐reported global evaluation showed that meloxicam IV 60 mg had the highest rating. There were no deaths, serious adverse events, or discontinuations due to adverse events. The incidence of subjects with ≥1 treatment‐emergent adverse event was greatest in the placebo group, followed by the groups that received ibuprofen, meloxicam IV 15 mg, 30 mg, and 60 mg. Nausea was the most commonly reported treatment‐emergent adverse event. Clinical trial registration number: NCT00945763.
Preparation of metal–organic frameworks hybridizing with attapulgite and adsorption behaviors for glutathione reduced
Authors: Liu Yi , Liu Yongfeng , Wang Hao , Dong Ling , Di Duolong 
Published: January 2018

AbstractBACKGROUNDA series of metal–organic frameworks (MOFs) hybrid materials resulting from the hybridization of MOFs and attapulgite were constructed using a facile reflux route under relatively low reaction temperature, and characterized by FTIR spectra, nitrogen adsorption–desorption isotherms, XRD and TGA. For the first time, MOFs hybridizing with attapulgite were employed to enrich peptides with high adsorption selectivity for glutathione reduced on the basis of three selected model peptides (glutathione reduced, bradykinin and insulin from bovine pancreas) due to pore structure, change in microenvironment and composition of the prepared MOFs materials, and molecular size of the selected peptides.RESULTSThe adsorption capacities of MOFs materials prepared at three different temperatures for glutathione reduced were 66.80, 88.91 and 79.55 mg g–1 in turn, while those of MOFs hybridization materials greatly enhanced, were 83.49, 99.64 and 97.47 mg g–1, respectively. The prepared MOFs materials exhibited excellent reusability. The results of FTIR spectra and X‐ray photoelectron spectroscopy showed that hydrogen bonding, the sieving effect, p‐π and the coordination effect were involved in the adsorption process.CONCLUSIONSThe excellent adsorption property and selectivity make the present materials highly promising and potentially useful in practical application as adsorbents for peptides with small molecular size such as glutathione reduced. © 2018 Society of Chemical Industry
Endoscopic ultrasound and the liver: current applications and beyond
Authors: Shah Neil D. , Baron Todd H. 
Published: January 2018

AbstractThe diagnosis and management of many gastrointestinal conditions has been augmented by the development of endoscopic ultrasound. Its role in the diagnosis and management of liver disease has been somewhat limited, but with the rapid development of therapeutic advancements it has quickly emerged as a useful tool in the management of complex hepatic conditions. This includes its use in the management of complications of portal hypertension as well as its use in liver lesions and cancer. In this paper, we review case studies, case series and trials for hepatic applications of endoscopic ultrasound to provide an overview of its utilization in this field and demonstrating its more novel applications for future use.
Quantitative [Fe]MRI determination of the dynamics of PSMA‐targeted SPIONs discriminates among prostate tumor xenografts based on their PSMA expression
Authors: Sillerud Laurel O. 
Published: January 2018

BackgroundThere is a need for a quantitative MRI method for iron concentration magnetic resonance imaging suitable for measuring the delivery of targeted superparamagnetic iron oxide nanoparticles (SPIONs) to tumors.PurposeTo apply our newly developed [Fe]MRI method to the quantitative imaging in both space and time of the iron dynamics of anti‐prostate specific membrane antigen (PSMA) conjugated SPIONs within human prostate tumor xenografts in nude mice.Study TypeLongitudinal.Animal Model45 Harlan Sprague Dawley athymic nude mice bearing xenografts from PSMA‐positive LNCaP, C4‐2 and PSMA‐negative DU145 tumors from human prostate tumor cell lines.Field Strength/Sequence1.0 Tesla/ T1 and T2 weighted spin echo.AssessmentImage intensity and contrast measurements.Statistical TestsStudent's t‐test.ResultsThe SPION diffusion coefficient within tumors was D = 44.8 ± 2.4 × 10−6 mm2/s. The iron taken up by PSMA‐positive LNCaP and C4‐2 tumors was proportional to the tail‐vein injected dose from 60 nmol to 1.6 μmol; injection of 1 μmol of iron in anti‐PSMA conjugated SPIONs resulted in a tumor [Fe] of 76 μM. Even at the highest iron dose of 1.6 μmol, the PSMA‐negative DU145 tumors took up no significant iron from the anti‐PSMA conjugated SPIONs. A similar lack of nonspecific uptake was observed when the antibodies against PSMA were omitted from the injected SPION preparation. The fraction of the initial iron dose that was taken up by PSMA‐positive tumors was 2.32 ± 0.75% (n = 10); uptake by the PSMA‐negative DU145 tumors and for SPIONs without anti‐PSMA antibodies was 0.16 ± 0.34% (n = 7) giving a ratio of [Fe] in PSMA + versus PSMA‐ tumors greater than 15:1 (P = 0.01).Data ConclusionQuantitative [Fe]MRI of anti‐PSMA conjugated SPIONs discriminated between PSMA‐positive LNCaP and C4‐2 and PSMA‐negative DU145 human prostate tumor xenografts in vivo.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017. J. MAGN. RESON. IMAGING 2018;48:469–481.
Preparation and evaluation of a deoxycholic‐calix[4]arene hybrid‐type receptor as a chiral stationary phase for HPLC
Authors: Yaghoubnejad Sadegh , Tabar Heydar Kourosh , Ahmadi Seyyed Hamid , Zadmard Reza , Ghonouei Nima 
Published: January 2018

AbstractWe report the synthesis and enantioseparation characteristics of two novel covalently immobilized deoxycholic acid derivatives as chiral stationary phases for high‐performance liquid chromatography. In the structure of the first stationary phase, the 3‐position of deoxycholic acid is substituted with a 3,5‐dinitrophenylcarbamoyl group and the second one has an additional calix[4]arene attached to the carboxylic group of the deoxycholic acid. The chromatographic performance of the stationary phases was evaluated with enantioseparation of N‐(3,5‐dinitrobenzoyl)‐dl‐leucine, N‐(3,5‐dinitrobenzoyl)‐dl‐valine, omeprazole, diclofop‐methyl, dl‐mandelic acid and (RS)‐pregabalin. Comparison of the performance characteristics of the prepared chiral stationary phases provided evidence for the active involvement of the calix[4]arene unit in the chiral recognition process. Both stationary phases are chemically bonded to the silica and can be used in both normal‐phase and reversed‐phase modes.
Synthesis, Properties, and Solar Cell Performance of Poly(4‐(p‐alkoxystyryl)thiazole)s
Authors: Jäger Jakob , Schraff Sandra , Pammer Frank 
Published: January 2018

AbstractA series of polythiazoles (PvTzs) featuring conjugated styryl sidechains equipped with different solubilizing p‐alkoxy‐groups (OR, R = n‐octyl, n‐dodecyl, 2‐ethylhexyl, 2‐hexyldecyl) is prepared by Negishi‐coupling polycondensation. Soluble material with number‐average molecular weights of up to Mn = 8.5 kDa (polydispersity (PDI) = 1.3, degree of polymerization (DPn) ≈ 20) is obtained, with a head‐to‐tail content of the PvTzs of ≈77%, as estimated from comparison with reference polymers. The polymers exhibit optical absorption properties similar to their polythiophene analogues, while their electrochemical characterization shows a significant stabilization of their frontier orbital levels. Fluorescence measurements indicate that upon excitation of the electron rich alkoxystyryl side‐chains charge transfer onto the more electron deficient polythiazole backbone occurs. This finding is corroborated by density functional theory (DFT) calculations on oligomeric model systems, which also consistently reproduce the optical properties observed for the polymers. The potentialities of these materials for applications in organic electronics can be demonstrated by their use as donor materials in organic photovoltaic cells, which exhibit higher open circuit voltages (VOC, up to 0.86 V) than P3HT‐ or analogous polythiophene‐based cells (VOC = 0.5–0.6 V).
Mechanical Reinforcement of Low‐Concentration Alginate Fibers by Microfluidic Embedding of Multiple Cores
Authors: Yoon Dong Hyun , Tanaka Daiki , Sekiguchi Tetsushi , Shoji Shuichi 
Published: January 2018

AbstractThis paper presents mechanically reinforced low‐concentration alginate fibers by embedding inner cores of high‐concentration alginate. 3D structures by stacking multiple polydimethylsiloxane (PDMS) layers allow the microfluidic formation and control of the isolated cores in the continuous flow. The alginate hydrogel fibers are simply spun, and the compartments, central core, surrounding cores, and outer shell layer are successfully verified. The results demonstrate the great potential for the development of complex fibrous materials, particularly for biological applications, which require specific morphology and composition of the fibers.
Improved Electron Transport with Reduced Contact Resistance in N‐Doped Polymer Field‐Effect Transistors with a Dimeric Dopant
Authors: Wang Rong , Guo Yikun , Zhang Di , Zhou Huiqiong , Zhao Dahui , Zhang Yuan 
Published: January 2018

AbstractAttaining control on charge injection properties is significant for meaningful applications of organic field‐effect transistors (OFETs). Here, molecular electron‐doping is applied with an air‐stable dimer dopant for n‐type OFETs based on (naphthalene diimide–diketopyrrolopyrrole) polymer hosts. Through investigating the doping effect on contact and transport properties, it is found that the electron transport increases in n‐doped OFETs at low doping regime with remaining large on/off ratios. These favorable meliorations are reconciled by the mitigated impacts of contact resistance and interfacial traps, as well as the surface morphology exhibiting features of increased ordering. The occurrence of doping in the presence of dimer dopants is evidenced by the observed shift of Fermi level toward vacuum level coupled with compositional analysis. Without applying vacuum‐deposition‐based contact doping, charge injection efficiencies are gained without losing OFET characteristics using the solution‐based methodology.
Determination and verification of the gap dependent heat transfer coefficient during permanent mold casting of A356 aluminum alloy
Authors: Ahmadein M. , Pustal B. , Wolff N. , Bührig‐Polaczek A. 
Published: January 2018

AbstractIn complex castings, the heat transfer across the casting / mold interface depends on the local gap size and contact pressure. Thus, an experimental setup is constructed to measure and evaluate the air‐gap dependent heat transfer coefficient during solidification of an A356 permanent mold casting. In order to evaluate the heat transfer coefficient, the temperature gradient and air gap development is measured at the casting / mold interface. This allows the interface temperatures and the time‐dependent heat flux across the gap to be calculated as a function of the measured gap size. Furthermore, the heat transfer coefficient and gap size are correlated to the interface temperature of the casting. The experimental setup and the evaluation procedure provide consistent and reproducible results. The heat transfer coefficient thus evaluated is employed to simulate the experimental setup. The temperatures measured are well reproduced. The results of the present work are compared to simulations using two heat transfer coefficient functions found in literature. This comparison shows a substantial improvement over the state of the art. This improvement is due to the exact knowledge of gap formation and the corresponding values of the heat transfer coefficient.
Characterization of macromolecular baseline of human brain using metabolite cycled semi‐LASER at 9.4T
Authors: Giapitzakis Ioannis‐Angelos , Avdievich Nikolai , Henning Anke 
Published: January 2018

PurposeMacromolecular resonances (MM) arise mainly from cytosolic proteins and overlap with metabolites, influencing metabolite quantification. Macromolecules can serve as valuable biomarkers for diseases and pathologies. The objectives of this study were to characterize MM at 9.4T in the human brain (occipital and left parietal lobe) and to describe the RF coil setup used for MM acquisition in the two regions.MethodsAn adiabatic inversion pulse was optimised for metabolite nulling at 9.4T using double inversion recovery and was combined for the first time with metabolite cycled (MC) semi‐LASER and appropriate coil configuration. MM spectra (seven volunteers) from two brain locations were averaged and smoothed creating MM templates, which were then parametrized using simulated Voigt‐shaped lines within LCModel. Quantification was performed on individual data sets, including corrections for different tissue composition and the T1 and T2 relaxation of water.ResultsOur coil configuration method resulted in efficient
(>30 T/√kW) for both brain regions. The 15 MM components were detected and quantified in MM baselines of the two brain areas. No significant differences in concentration levels of MM between different regions were found. Two new MM peaks were reported (M7 & M8).ConclusionDouble inversion, which was combined with MC semi‐LASER, enabled the acquisition of high spectral resolution MM spectra for both brain regions at 9.4T. The 15 MM components were detected and quantified. Two new MM peaks were reported for the first time (M7 & M8) and preliminarily assigned to β‐methylene protons of aspartyl‐groups. Magn Reson Med 80:462–473, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
A bayesian method for accelerated magnetic resonance elastography of the liver
Authors: Ebersole Christopher , Ahmad Rizwan , Rich Adam V. , Potter Lee C. , Dong Huiming , Kolipaka Arunark 
Published: January 2018

PurposeMagnetic resonance elastography is a noninvasive tool for quantifying soft tissue stiffness. Magnetic resonance elastography has been adopted as a clinical method for staging liver fibrosis. However, the application of liver magnetic resonance elastography requires multiple lengthy breath‐holds. We propose a new data acquisition and processing method to reduce magnetic resonance elastography scan time.MethodsA Bayesian image reconstruction method that uses transform sparsity and magnitude consistency across different phase offsets to recover images from highly undersampled data is proposed. The method is validated using retrospectively down‐sampled phantom data and prospectively down‐sampled in vivo data (N = 86).ResultsThe proposed technique allows accurate quantification of mean liver stiffness up to an acceleration factor of R = 6, enabling acquisition of a slice in 4.3 s. Bland‐Altman analysis indicates that the proposed technique (R = 6) has a bias of −0.04 kPa and limits of agreement of −0.36 to + 0.28 kPa when compared with traditional generalized autocalibrating partial parallel acquisition reconstruction (R = 1.4).ConclusionBy exploiting transform sparsity and magnitude consistency, accurate quantification of mean stiffness in the liver can be obtained at an acceleration rate of up to R = 6. This potentially enables the collection of three to four liver slices, as per clinical protocol, within a single breath‐hold. Magn Reson Med 80:1178–1188, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
Age‐associated urethral dysfunction in urethane‐anesthetized rats
Authors: Kimura Ryu , Miyazato Minoru , Ashikari Asuka , Oshiro Takuma , Saito Seiichi 
Published: January 2018

AimsWe aimed to investigate the age‐associated changes in movement coordination between the urinary bladder and the urethra in rats.MethodsA total of 17 female Sprague‐Dawley rats were used. The rats were divided into young (3 months old) and middle‐aged (12‐15 months old) groups. In both groups, isovolumetric cystometry and urethral perfusion pressure (UPP) measurements were performed under urethane anesthesia. After the rhythmic bladder contractions stabilized, L‐arginine, a nitric oxide (NO) substrate (100 mg/kg), was administered intravenously in both groups. Subsequently, N‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME) (50 mg/kg) was injected intravenously to inhibit NO synthase activity in both groups.ResultsUPP change, defined as UPP nadir minus baseline UPP, was significantly smaller in middle‐aged rats (64%) than in young rats (P < 0.05). The mean amplitude of high‐frequency oscillations (HFOs) of the external urethral sphincter was also significantly lower (62%) in middle‐aged rats than that in young rats (P < 0.05). Urethral contraction during UPP change was also noted in middle‐aged rats. This urethral contraction disappeared after L‐arginine administration. UPP nadir during bladder contraction was inhibited by L‐NAME in both groups. UPP change was greater in middle‐aged rats than in young rats, and 3 out of 9 middle‐aged rats showed a detrusor‐sphincter dyssynergia pattern after L‐NAME.ConclusionsThe results indicated that aging induces dysfunction in movement coordination between the urinary bladder and the urethra. Thus, age‐associated urethral dysfunctions may lead to inefficient voiding with increased post‐void residual urine volume, which is often observed in elderly populations.
A novel hybrid model predictive control design with application to a quadrotor helicopter
Authors: Jalili Sadegh , Rezaie Behrooz , Rahmani Zahra 
Published: January 2018

SummaryIn this paper, a novel control design strategy based on a hybrid model predictive control in combination with fuzzy logic control is presented for a quadrotor helicopter system. In the proposed scheme, a 2‐part control structure is used. In the first part, a linear model predictive controller with receding horizon design strategy is combined with a nonlinear model predictive controller, which is applied as the main controller. In the second part, a 2‐level fuzzy logic controller is utilized to assist the first controller when the error exceeds a predefined value. The proposed nonlinear predictive control method utilizes a novel approach in which a prediction of the future outputs is used in the modeling stage. Using this simple technique, the problem can be solved using linear methods and, thereby, due to considerable reduction in the computational cost, it will be applicable for the systems with fast dynamics. Moreover, the fuzzy logic controller is used as a supervisor to adjust a proportional‐integral‐derivative controller to enhance the system performance by decreasing the tracking error. The proposed scheme is applied to a model of quadrotor system such that the difference between the predicted output of the system and the reference value is minimized while there are some constraints on inputs and outputs of the nonlinear quadrotor system. Simulation results demonstrate the efficiency of the proposed control scheme for the quadrotor system model.
Impact of baseline clinical and laboratory features on the risk of thrombosis in children with acute lymphoblastic leukemia: A prospective evaluation
Authors: Athale Uma H. , Mizrahi T. , Laverdière C. , Nayiager T. , Delva Y.‐L. , Foster G. , Thabane L. , David M. , Leclerc J.‐M. , Chan A. K. C. 
Published: January 2018

AbstractBackgroundChildren with acute lymphoblastic leukemia (ALL) have increased risk of thromboembolism (TE). However, the predictors of ALL‐associated TE are as yet uncertain.ObjectiveThis exploratory, prospective cohort study evaluated the effects of clinical (age, gender, ALL risk group) and laboratory variables (hematological parameters, ABO blood group, inherited and acquired prothrombotic defects [PDs]) at diagnosis on the development of symptomatic TE (sTE) in children (aged 1 to ≤18) treated on the Dana‐Farber Cancer Institute ALL 05‐001 study.ProceduresSamples collected prior to the start of ALL therapy were evaluated for genetic and acquired PDs (proteins C and S, antithrombin, procoagulant factors VIII (FVIII:C), IX, XI and von Willebrand factor antigen levels, gene polymorphisms of factor V G1691A, prothrombin gene G20210A and methylene tetrahydrofolate reductase C677T, anticardiolipin antibodies, fasting lipoprotein(a), and homocysteine).ResultsOf 131 enrolled patients (mean age [range] 6.4 [1–17] years) 70 were male patients and 20 patients (15%) developed sTE. Acquired or inherited PD had no impact on the risk of sTE. Multivariable analyses identified older age (odds ratio [OR] 1.13; 95% confidence interval [CI]: 1.01, 1.26) and non‐O blood group (OR 3.64, 95% CI: 1.06, 12.51) as independent predictors for development of sTE. Patients with circulating blasts had higher odds of developing sTE (OR 6.66; 95% CI: 0.82, 53.85).ConclusionOlder age, non‐O blood group, and presence of circulating blasts, but not PDs, predicted the risk of sTE during ALL therapy. We recommend evaluation of these novel risk factors in the development of ALL‐associated TE. If confirmed, these easily accessible variables at diagnosis can help develop a risk‐prediction model for ALL‐associated TE.
Device physics underlying silicon heterojunction and passivating‐contact solar cells: A topical review
Authors: Chavali Raghu V. K. , De Wolf Stefaan , Alam Muhammad A. 
Published: January 2018

AbstractThe device physics of commercially dominant diffused‐junction silicon solar cells is well understood, allowing sophisticated optimization of this class of devices. Recently, so‐called passivating‐contact solar cell technologies have become prominent, with Kaneka setting the world's silicon solar cell efficiency record of 26.63% using silicon heterojunction contacts in an interdigitated configuration. Although passivating‐contact solar cells are remarkably efficient, their underlying device physics is not yet completely understood, not in the least because they are constructed from diverse materials that may introduce electronic barriers in the current flow. To bridge this gap in understanding, we explore the device physics of passivating contact silicon heterojunction (SHJ) solar cells. Here, we identify the key properties of heterojunctions that affect cell efficiency, analyze the dependence of key heterojunction properties on carrier transport under light and dark conditions, provide a self‐consistent multiprobe approach to extract heterojunction parameters using several characterization techniques (including dark J‐V, light J‐V, C‐V, admittance spectroscopy, and Suns‐Voc), propose design guidelines to address bottlenecks in energy production in SHJ cells, and develop a process‐to‐module modeling framework to establish the module's performance limits. We expect that our proposed guidelines resulting from this multiscale and self‐consistent framework will improve the performance of future SHJ cells as well as other passivating contact‐based solar cells.