bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-standing aggressive angiomyxoma as a paratesticular mass: A case report and review of literature
Authors: Aydin Ahmet M , Katipoglu Kubra , Baydar Dilek E , Bilen Cenk Y 
Published: June 2017

Objectives: Aggressive angiomyxoma is known as a mesenchymal tumor of premenopausal women and it is extremely rare in men. Methods: Herein, we report a 66-year-old male with a firm scrotal mass that had gradually enlarged over 20 years. Results: Radiological studies revealed 10 x 15 cm mass lesion confined to right scrotum with neither local invasion nor distant metastasis. Inguinal orchiectomy was performed and histopathology showed characteristic features of an aggressive angiomyxoma occupying paratesticular region, which was a challenging diagnosis due to its unexpected occurrence in the male gender. Conclusion: Aggressive angiomyxoma is mostly considered as a benign tumor in females despite its propensity for local recurrence. Whether it may show a divergent biological behavior in men is unknown as the reported cases are too few.
Help seeking for social anxiety: A pilot randomised controlled trial
Authors: Griffiths Kathleen M , Walker Jennie , Batterham Philip J 
Published: June 2017

Objective Although social anxiety disorder is a persistent and debilitating condition, only a minority of people with social anxiety disorder seek help and little is known about methods for promoting help seeking for social anxiety disorder. This pilot trial explored the potential effectiveness of an online program designed to increase help-seeking intentions for social anxiety disorder. Methods Australian adults with symptoms of untreated social anxiety disorder were recruited online and randomised to either the Shyness Information Online intervention ( n = 41) or an online attention control condition ( n = 41). Each program together with a baseline and postintervention survey was delivered in one session. The primary outcome was intentions to seek help from a professional. Secondary measures included anxiety literacy, help-seeking attitudes, internalised stigma, and perceived need for treatment. The acceptability of the program content and feasibility of the recruitment method were also examined. Results Although they did not demonstrate a significantly greater increase in help-seeking intentions relative to the control group ( p = 0.097), those receiving the intervention showed more favourable attitudes towards seeking psychological help (Hedges’ g = 0.38; p = 0.025) and a higher level of perceived need for treatment ( p ≤ 0.001). Participants also showed a greater knowledge about social anxiety disorder at post-intervention than the control participants (adjusted Hedges’ g = 0.46, p < 0.001). Most respondents were satisfied with the intervention content; the recruitment strategy appeared feasible. Conclusions Further investigation of the intervention is warranted to test its effectiveness, explore the relationships between factors that influence social anxiety disorder help-seeking behaviour and to further test the validity of the social anxiety disorder help-seeking model on which the intervention was based.
How I treat chronic myelomonocytic leukemia
Authors: Solary Eric , Itzykson Raphael 
Published: June 2017

Abstract
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that may deserve specific management. Defined by a persistent peripheral blood monocytosis ≥1 × 109/L and monocytes accounting for ≥10% of the white blood cells, this aging-associated disease combines cell proliferation as a consequence of myeloid progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor with myeloid cell dysplasia and ineffective hematopoiesis. The only curative option for CMML remains allogeneic stem cell transplantation. When transplantation is excluded, CMML is stratified into myelodysplastic (white blood cell count <13 × 109/L) and proliferative (white blood cell count ≥13 × 109/L) CMML. In the absence of poor prognostic factors, the management of myelodysplastic CMML is largely inspired from myelodysplastic syndromes, relying on erythropoiesis-stimulating agents to cope with anemia, and careful monitoring and supportive care, whereas the management of proliferative CMML usually relies on cytoreductive agents such as hydroxyurea, although ongoing studies will help delineate the role of hypomethylating agents in this patient population. In the presence of excessive blasts and other poor prognostic factors, hypomethylating agents are the preferred option, even though their impact on leukemic transformation and survival has not been proved. The therapeutic choice is illustrated by 4 clinical situations among the most commonly seen. Although current therapeutic options can improve patient’s quality of life, they barely modify disease evolution. Improved understanding of CMML pathophysiology will hopefully lead to the exploration of novel targets that potentially would be curative.
Coping and Prognostic Awareness in Patients With Advanced Cancer
Authors: Nipp Ryan D. , Greer Joseph A. , El-Jawahri Areej , Moran Samantha M. , Traeger Lara , Jacobs Jamie M. , Jacobsen Juliet C. , Gallagher Emily R. , Park Elyse R. , Ryan David P. , Jackson Vicki A. , Pirl William F. , Temel Jennifer S. 
Published: June 2017

Purpose Patients’ understanding of their illness is key for making informed treatment decisions, yet studies suggest an association between prognostic awareness and worse quality of life (QOL) and mood among patients with advanced cancer. We sought to explore the relationships among prognostic awareness, coping, QOL, and mood in patients with newly diagnosed, incurable cancer. Methods We assessed patients’ self-reported health status and treatment goal (Prognosis and Treatment Perceptions Questionnaire), coping (Brief COPE), QOL (Functional Assessment of Cancer Therapy-General), and mood (Hospital Anxiety and Depression Scale) within 8 weeks of incurable lung or GI cancer diagnosis. We used linear regression to examine associations and interaction effects among patients’ health status and treatment goal, coping strategies, QOL, and mood. Results Patients who reported a terminally ill health status had worse QOL (unstandardized coefficient [B] = −6.88; P < .001), depression (B = 1.60; P < .001), and anxiety (B = 1.17; P = .007). Patients who reported their oncologist’s treatment goal was “to cure my cancer” had better QOL (B = 4.33; P = .03) and less anxiety (B = −1.39; P = .007). We observed interaction effects between self-reported health status and treatment goal and certain coping strategies. Specifically, subgroup analyses showed that greater use of positive reframing was related to better QOL (B = 2.61; P < .001) and less depression (B = −0.78; P < .001) among patients who reported a terminally ill health status. Active coping was associated with better QOL (B = 3.50; P < .001) and less depression (B = −1.01; P < .001) among patients who acknowledged their oncologist’s treatment goal was not “to cure my cancer.” Conclusion Prognostic awareness is related to worse QOL and mood in patients with newly diagnosed, incurable cancer; however, the use of certain coping strategies may buffer these relationships. Interventions to improve patients’ prognostic awareness should seek to cultivate more adaptive coping strategies in order to enhance QOL and mood.
Do the American Society of Clinical Oncology Value Framework and the European Society of Medical Oncology Magnitude of Clinical Benefit Scale Measure the Same Construct of Clinical Benefit?
Authors: Cheng Sierra , McDonald Erica J. , Cheung Matthew C. , Arciero Vanessa S. , Qureshi Mahin , Jiang Di , Ezeife Doreen , Sabharwal Mona , Chambers Alexandra , Han Dolly , Leighl Natasha , Sabarre Kelley-Anne , Chan Kelvin K.W. 
Published: June 2017

Purpose Whether the ASCO Value Framework and the European Society for Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale (MCBS) measure similar constructs of clinical benefit is unclear. It is also unclear how they relate to quality-adjusted life-years (QALYs) and funding recommendations in the United Kingdom and Canada. Methods Randomized clinical trials of oncology drug approvals by the US Food and Drug Administration, European Medicines Agency, and Health Canada between 2006 and August 2015 were identified and scored using the ASCO version 1 (v1) framework, ASCO version 2 (v2) framework, and ESMO-MCBS by at least two independent reviewers. Spearman correlation coefficients were calculated to assess construct (between frameworks) and criterion validity (against QALYs from the National Institute for Health and Care Excellence [NICE] and the pan-Canadian Oncology Drug Review [pCODR]). Associations between scores and NICE/pCODR recommendations were examined. Inter-rater reliability was assessed using intraclass correlation coefficients. Results From 109 included randomized clinical trials, 108 ASCOv1, 111 ASCOv2, and 83 ESMO scores were determined. Correlation coefficients for ASCOv1 versus ESMO, ASCOv2 versus ESMO, and ASCOv1 versus ASCOv2 were 0.36 (95% CI, 0.15 to 0.54), 0.17 (95% CI, −0.06 to 0.37), and 0.50 (95% CI, 0.35 to 0.63), respectively. Compared with NICE QALYs, correlation coefficients were 0.45 (ASCOv1), 0.53 (ASCOv2), and 0.46 (ESMO); with pCODR QALYs, coefficients were 0.19 (ASCOv1), 0.20 (ASCOv2), and 0.36 (ESMO). None of the frameworks were significantly associated with NICE/pCODR recommendations. Inter-rater reliability was good for all frameworks. Conclusion The weak-to-moderate correlations of the ASCO frameworks with the ESMO-MCBS, as well as their correlations with QALYs and with NICE/pCODR funding recommendations, suggest different constructs of clinical benefit measured. Construct convergent validity with the ESMO-MCBS did not increase with the updated ASCO framework.
Mechanically Enhanced Hyaluronic Acid Hybrid Hydrogels with Halloysite Nanotubes
Authors: Park Kyung-Lynne , Ma Wei , Higaki Yuji , Takahara Atsushi 
Published: June 2017

Abstract
Hybrid hydrogels composed of hyaluronic acid (HA) and halloysite nanotubes (HNTs) were prepared via photocrosslinking of HA and HNTs functionalized with vinyl groups. These hybrid hydrogels showed enhanced mechanical properties without sacrificing good swelling capability, which is crucial for biomedical applications.
Occlusive Shrinkage of Ovation Endograft Presenting as Acute Lower Limb Ischemia
Authors: Bianchi Paolo , Scalise Filippo , Mortara Andrea , Lanzillo Guido , Scardina Giuseppe , Trimarchi Santi , Parati Gianfranco , Tolva Valerio 
Published: June 2017

AbstractThe aim of this report is to describe the imaging and successful treatment of an acute shrinkage of the Ovation Abdominal Stent Graft System. The Ovation Prime system utilizes a polymer-filled sealing ring that is cast in situ at the margin of the aneurysm; however, the residual endograft inner volume after ring filling may reduce volume and graft flow. Nevertheless, there are no reports about severe complications using the Ovation Prime system. A 75-year-old male presented to our hospital for acute lower limb ischemia. The patient reported a previous endograft for abdominal aortic aneurysm 1 month previously, which utilized the Ovation device. Computed tomography (CT) angiography demonstrated a critical narrowing of the endograft at the site of the proximal sealing rings. We decided on urgent treatment, delivering a covered stent graft (CP STENT NUMED™). Intraoperative intravascular ultrasound showed effective compaction of the proximal rings. Nine-month follow-up with CT angiography demonstrated good patency without ring recoil of the endograft. This is the first report of endovascular treatment for an acute and symptomatic shrinkage of proximal rings in the Ovation trivascular endograft. Angiographic and intravascular ultrasound findings showed that covered stenting is effective and that the ring polymer is safely moldable.
A Case of Primary Aortoduodenal Fistula and Abdominal Aortic Aneurysm in a Patient with Chronic Q Fever
Authors: de Niet Arne , Tielliu Ignace , van Schaik Paul , van den Dungen Jan , Zeebregts Clark 
Published: June 2017

AbstractA 70-year-old man was successfully treated for an aortoduodenal fistula originating from a Q fever-related abdominal aortic aneurysm. He had no known history of contact with cattle or sheep. Although the combination of abdominal aortic aneurysm and aortoduodenal fistula is rare, one should be suspicious of Q fever infection as the causative agent, and additional medical treatment should be initiated.
The Irish legislative gender quota: The first election
Authors: Brennan Mary , Buckley Fiona 
Published: June 2017

Abstract
In 2012 legislative gender quotas were introduced as part of the Fine Gael/Labour coalition government’s political reform agenda. The legislation specifies that payments to political parties ‘shall be reduced by 50 per cent, unless at least 30 per cent of the candidates whose candidatures were authenticated by the qualified party at the preceding general election were women and at least 30 per cent were men’. The 30 per cent gender threshold came into effect at the 2016 general election. Research demonstrates that gender quotas work to increase women’s political descriptive representation, but to do so, political parties must engage with them in ‘goodwill’, be ‘wellintentioned’ or place women in ‘winnable seats’. This article examines if this was the case at the 2016 general election. Using statistics, as well as drawing from interviews with party strategists, the article assesses the impact of gender quotas on women’s candidate selection and election. We conclude that parties did embrace the spirit of the gender quota law but resistance remains.
Dáil reforms since 2011: Pathway to power for the ‘puny’ parliament?
Authors: Lynch Catherine , O’Malley Eoin , Reidy Theresa , Farrell David M. , Suiter Jane 
Published: June 2017

Abstract
We know that the Dáil is dominated by the government. From 2010 to 2016 there was a clamour for change, which ultimately led to significant reforms of the Oireachtas, and specifically the Dáil. In this article we show that the basis for the weakness of the Dáil was the government’s control of the legislative agenda. This article tracks the changes that were made, and we make an early assessment of them. However, firm conclusions are difficult to draw because of the extent to which the strengthening of the Dáil is a function of the weak position of the current minority government.
‘Insufficient critique’ – The Oireachtas Banking Inquiry and the media
Authors: Rafter Kevin 
Published: June 2017

Abstract
A parliamentary inquiry into the Irish banking collapse was formally established in November 2014, tasked with examining relevant issues from the period of January 1992 to December 2013. In focusing on the role played by the media - and where reportage may have impacted on, or contributed to, the crisis - the Banking Inquiry heard from eight senior media executives who held either commercial or editorial positions in four media organisations in Ireland during the period of the economic boom and subsequent collapse. This article focuses on the engagement of these media witnesses with the inquiry, drawing on written submissions and oral evidence. Having reviewed the place of journalism in a democracy and examined the role of journalism during the economic crisis, the article considers the Banking Inquiry’s final report, specifically in relation to the media. The review concludes that this parliamentary inquiry did not assist in advancing a serious understanding of the work undertaken by the Irish media in the pre-2007 period and that, ultimately, for all involved this engagement was a missed opportunity.
A Comparative Analysis of Serum Lipids in Patients with Chronic Hepatitis C, Nonalcoholic Fatty Liver Disease and Healthy Controls
Authors: Valkov I. , Ivanova R. , Marinova C. , Alexiev A. , Antonov K. , Jelev D. , Ivanova R. S. , Mateva L. 
Published: June 2017

Abstract
Serum lipids abnormalities are widespread among patients with chronic hepatitis C (CHC), but the impact of concomitant hepatic steatosis [steatosis, nonalcoholic steatosis (NAS)], as well as distinctions between it and nonalcoholic fatty liver disease (NAFLD) are not well established yet. The aim of the study was to assess and compare the serum lipids in patients with genotype 1 CHC with and without steatosis, those with NAFLD, and healthy controls (HC). A total of 1010 subjects were included in this study: 366 CHC genotype 1 patients with steatosis (n = 227) and without steatosis (n = 139), 403 NAFLD patients, and 241 HC without fatty liver or other disease, matched for age and gender. Serum lipids, body mass index (BMI), components of metabolic syndrome (MS), and serum insulin levels were evaluated. In addition serum lipoprotein (a) [Lp(a)] levels were studied in 112 CHC and 80 NAFLD patients. The mean levels of total cholesterol, LDL-cholesterol and triglycerides (Tg) were higher and the mean levels of HDL-cholesterol were lower in all patients with steatosis (CHC and NAFLD) than in CHC cases without steatosis (p < 0.05 and p = 0.001, resp.). Higher prevalence and severity of lipid abnormalities, including Lp(a), were observed in patients with NAFLD than in those with CHC (p < 0.001). No difference was found between CHC patients without steatosis and HC. Higher prevalence and grade of glucose metabolic abnormalities were also observed in patients with NAFLD and CHC with steatosis than in cases without steatosis (p < 0.05 and p = 0.001, resp.). Lipid and glucose metabolic abnormalities in patients with CHC were dependent on steatosis. CHC with steatosis and NAFLD were associated with insulin resistant type dyslipidemia, with total cholesterol and LDL-cholesterol being generally lower in CHC.
Ileal mesenteric cyst in young patient – Case presentation
Authors: Chisalau V. , Tica C. , Chirila S. , Ionescu C. 
Published: June 2017

Abstract
Mesenteric cysts represent rare diseases of the abdominal cavity. The low incidence and the nonspecific clinical manifestations lead to a difficult diagnosis. Most of the time, these are diagnosed in advanced stages when complications arise or by chance following routine imagistic investigations. The ideal treatment for mesenteric cysts is the total surgical removal. The prognostic is favorable in most of the cases.
Jüdische Sportfunktionäre im Wien der Zwischenkriegszeit und Jewish Difference. Zur Methodik eines Forschungsprojekts
Authors: Hachleitner Bernhard 
Published: June 2017

AbstractThis article gives an overview of the research project »Jewish Sports Officials in Interwar Vienna«. The project uses the example of Jewish sports officials to reconstruct the social field of sport as a site of identity politics in Vienna during the interwar period. It tries to show the significance of sports officials for questions of
Der jüdische Sport im Salzburg der Zwischenkriegszeit
Authors: Praher Andreas , Schwarzbauer Robert 
Published: June 2017

AbstractThe Jewish community in Salzburg before 1938 never exceeded 300 and there were consequently hardly any Jewish sportsmen/women. Anti-Semitism was quite common, especially in the city of Salzburg, where nearly the whole Jewish community lived and where sport had been established by that time. There were, nevertheless, a few personalities who had a major impact on the development of sport (i. e. football) in Salzburg such as Johann (Isak) Dachinger, who played a part in the foundation of Austria Salzburg in 1933, Erwin Bonyhadi, who was an official in various clubs and the SFV (Salzburg Football Association), and Ferdinand Morawetz, the »founding father of football in Salzburg«, who was co-founder and official of the two oldest football clubs, helped to establish an independent football association in Salzburg in 1921, and was kicked out of Salzburger AK 1914 when the club introduced an Aryan Paragraph, just a few months after he had organised a football ground for the club.
Sport und die jüdische Suche nach Gemeinschaft in (ost-)europäischen Metropolen der Zwischenkriegszeit
Authors: Hilbrenner Anke 
Published: June 2017

AbstractThe main Jewish sport movement was and is Zionist (and as such nationalist), nevertheless I would claim that Jewish sport is a transnational practice par excellence. Sport, and especially Jewish sport, transcends the concept of nation and state, but sport historiography still follows national paradigms. The sport history of big cities might help to find an empirical basis for a transnational history of modern sports. The search for community and belonging is vital for the experience of the modern individual. From the nineteenth century onwards the »nation« was the preferred »imagined community« to fill the void left by religion and tradition after the age of Enlightenment. But there were other communities as well, such as the workers’ movement or other political communities and social classes or sporting communities. By looking at an East European Jewish metropolis such as Vilne (today’s Vilnius), I want to explore the ambiguous character of the Jewish sport movement and the agency of Jewish athletes in their search for identity and belonging.
One-carbon metabolism and ionizing radiation: a multifaceted interaction
Authors: Miousse Isabelle R. , Tobacyk Julia , Melnyk Stepan , James S. Jill , Cheema Amrita K. , Boerma Marjan , Hauer-Jensen Martin , Koturbash Igor 
Published: June 2017

AbstractIonizing radiation (IR) is a ubiquitous component of our environment and an important tool in research and medical treatment. At the same time, IR is a potent genotoxic and epigenotoxic stressor, exposure to which may lead to negative health outcomes. While the genotoxocity is well described and characterized, the epigenetic effects of exposure to IR and their mechanisms remain under-investigated. In this conceptual review, we propose the IR-induced changes to one-carbon metabolism as prerequisites to alterations in the cellular epigenome. We also provide evidence from both experimental and clinical studies describing the interactions between IR and one-carbon metabolism. We further discuss the potential for the manipulation of the one-carbon metabolism in clinical applications for the purpose of normal tissue protection and for increasing the radiosensitivity of cancerous cells.
Recent advances in the mechanism of selenoamino acids toxicity in eukaryotic cells
Authors: Lazard Myriam , Dauplais Marc , Blanquet Sylvain , Plateau Pierre 
Published: June 2017

AbstractSelenium is an essential trace element due to its incorporation into selenoproteins with important biological functions. However, at high doses it is toxic. Selenium toxicity is generally attributed to the induction of oxidative stress. However, it has become apparent that the mode of action of seleno-compounds varies, depending on its chemical form and speciation. Recent studies in various eukaryotic systems, in particular the model organismSaccharomyces cerevisiae, provide new insights on the cytotoxic mechanisms of selenomethionine and selenocysteine. This review first summarizes current knowledge on reactive oxygen species (ROS)-induced genotoxicity of inorganic selenium species. Then, we discuss recent advances on our understanding of the molecular mechanisms of selenocysteine and selenomethionine cytotoxicity. We present evidences indicating that both oxidative stress and ROS-independent mechanisms contribute to selenoamino acids cytotoxicity. These latter mechanisms include disruption of protein homeostasis by selenocysteine misincorporation in proteins and/or reaction of selenols with protein thiols.