bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control and Stabilization of the Gulf Stream by Oceanic Current Interaction with the Atmosphere
Authors: Renault Lionel , Molemaker M. Jeroen , Gula Jonathan , Masson Sebastien , McWilliams James C. 
Published: September 2016

AbstractThe Gulf Stream (GS) is known to have a strong influence on climate, for example, by transporting heat from the tropics to higher latitudes. Although the GS transport intensity presents a clear interannual variability, satellite observations reveal its mean path is stable. Numerical models can simulate some characteristics of the mean GS path, but persistent biases keep the GS separation and postseparation unstable and therefore unrealistic. This study investigates how the integration of ocean surface currents into the ocean–atmosphere coupling interface of numerical models impacts the GS. The authors show for the first time that the current feedback, through its eddy killing effect, stabilizes the GS separation and postseparation, resolving long-lasting biases in modeled GS path, at least for the Regional Oceanic Modeling System (ROMS). This key process should therefore be taken into account in oceanic numerical models. Using a set of oceanic and atmospheric coupled and uncoupled simulations, this study shows that the current feedback, by modulating the energy transfer from the atmosphere to the ocean, has two main effects on the ocean. On one hand, by reducing the mean surface stress and thus weakening the mean geostrophic wind work by 30%, the current feedback slows down the whole North Atlantic oceanic gyre, making the GS narrower and its transport weaker. Yet, on the other hand, the current feedback acts as an oceanic eddy killer, reducing the surface eddy kinetic energy by 27%. By inducing a surface stress curl opposite to the current vorticity, it deflects energy from the geostrophic current into the atmosphere and dampens eddies.
Evaluation of a Procedure to Correct Spatial Averaging in Turbulence Statistics from a Doppler Lidar by Comparing Time Series with an Ultrasonic Anemometer
Authors: Brugger Peter , Träumner Katja , Jung Christina 
Published: September 2016

AbstractDoppler lidars are frequently used for wind measurements in the atmospheric boundary layer, but their data are subject to spatial averaging due to the pulse length of the laser and sampling frequency of the return signal. This spatial averaging also affects estimates of turbulence statistics like the velocity variance and outer scale of turbulence from Doppler lidar data. In this study a procedure from Frehlich and Cornman based on a von Kármán turbulence model was systematically applied to correct these effects of spatial averaging on turbulence statistics. The model was able to reduce the occurring bias of the velocity variance and outer scale of turbulence in a comparison of time series from a Doppler lidar and an ultrasonic anemometer. The measurements show that the bias of the velocity variance was reduced by 29% and that of the outer scale of turbulence by 43%. But both turbulence parameters had a remaining systematic error that could not be explained by the von Kármán model of the structure function.
Reconstructing the Collective Memory of Mexico’s Dirty War
Authors: Mendoza García Jorge 
Published: September 2016

A silenced and forgotten period of the Mexican past is that of the dirty war unleashed by the state against social movements in the second half of the twentieth century, especially the guerrillas and suspected guerrillas of the 1960s and 1970s. The dirty war is an unresolved issue in terms of memory, acknowledgment, and justice for those who suffered violence at the hands of those in power. An account of part of this period that reconstructs the ideologization, clandestine detention, and torture suffered by victims of this dirty war from the perspective of collective memory contributes to filling the gap in knowledge about this period. La guerra sucia desatada por el estado mexicano en contra de los movimientos sociales en la segunda mitad del siglo XX (especialmente en contra de las guerrillas y las supuestas guerrillas de los años 60 y 70) es un periodo silenciado y olvidado del pasado mexicano. Esta guerra sucia es un asunto pendiente en términos de memoria, reconocimiento y justicia para aquellos que sufrieron la violencia a manos del poder establecido. Un relato de una parte de este período que desde la perspectiva de la memoria colectiva reconstruya la ideologización, la detención clandestina y la tortura que sufrieron las víctimas de la guerra sucia servirá para llenar las lagunas en el conocimiento sobre este período.
The under reporting of recruitment strategies in research with children with life-threatening illnesses: A systematic review
Authors: Hudson Briony F , Oostendorp Linda JM , Candy Bridget , Vickerstaff Victoria , Jones Louise , Lakhanpaul Monica , Bluebond-Langner Myra , Stone Paddy 
Published: September 2016

Background: Researchers report difficulties in conducting research with children and young people with life-limiting conditions or life-threatening illnesses and their families. Recruitment is challenged by barriers including ethical, logistical and clinical considerations. Aim: To explore how children and young people (aged 0–25 years) with life-limiting conditions or life-threatening illnesses and their families were identified, invited and consented to research published in the last 5 years. Design: Systematic review. Data sources: MEDLINE, PsycINFO, Web of Science, Sciences Citation Index and SCOPUS were searched for original English language research published between 2009 and 2014, recruiting children and young people with life-limiting conditions or life-threatening illness and their families. Results: A total of 215 studies – 152 qualitative, 54 quantitative and 9 mixed methods – were included. Limited recruitment information but a range of strategies and difficulties were provided. The proportion of eligible participants from those screened could not be calculated in 80% of studies. Recruitment rates could not be calculated in 77%. A total of 31% of studies recruited less than 50% of eligible participants. Reasons given for non-invitation included missing clinical or contact data, or clinician judgements of participant unsuitability. Reasons for non-participation included lack of interest and participants’ perceptions of potential burdens. Conclusion: All stages of recruitment were under reported. Transparency in reporting of participant identification, invitation and consent is needed to enable researchers to understand research implications, bias risk and to whom results apply. Research is needed to explore why consenting participants decide to take part or not and their experiences of research recruitment.
Does listening to music during flexible cystoscopy and bladder biopsy decrease patient’s pain?
Authors: Falavolti Cristina , Sergi Federico , Petitti Tommasangelo , Buscarini Maurizio 
Published: September 2016

Aim: The aim of this study was to demonstrate that listening to music during flexible cystoscopy and cold cup biopsy decreases patient pain. Materials and methods: We analysed 100 patients who underwent flexible cystoscopy plus at least one cold cup biopsy (50 control patients without music and 50 patients with classical music). Before cystoscopy, these patients were tested for urinary analysis and culture, and then they received the same local anaesthesia. Hemodynamic values were also collected for each patient. After the procedure, the visual analog scale (VAS) of 0–10 and the numeric pain intensity scale (NRS) were used to report the patient’s pain during the cystoscopy. Results: Both groups were similar with regards to the reasons for undergoing cystoscopy. Group 1 patients (no music controls) reported higher values of VAS and NRS, compared to patients in Group 2 (classical music; p < 0.001). No significant differences were detected between the two groups regarding hemodynamic parameters. Conclusions: In our experience, music significantly reduced feelings of pain.
Endoscopic Extra-articular Surgical Removal of Heterotopic Ossification of the Rectus Femoris Tendon in a Series of Athletes
Authors: Comba Fernando , Piuzzi Nicolás S. , Oñativia José Ignacio , Zanotti Gerardo , Buttaro Martín , Piccaluga Francisco 
Published: September 2016

Background: Calcific deposits in tendon, muscles, and periarticular areas are very common. Heterotopic ossification of the rectus femoris (HORF) is a rare condition, and several theories exist regarding the etiopathogenesis, which appears to be multifactorial with traumatic, genetic, and local metabolic factors involved. Although HORF typically responds to nonoperative treatment, when this approach fails, endoscopic treatment is a minimally invasive technique to address the pathology. Purpose: To report the clinical and radiological outcomes of 9 athletes with HORF who underwent endoscopic resection. Study Design: Case series; Level of evidence, 4. Methods: Nine male athletes were treated with endoscopic extra-articular resection of HORF after failure of a 6-month course of nonoperative treatment. All patients were studied with radiographs, computed tomography, and magnetic resonance imaging. Outcomes were assessed clinically using the modified Harris Hip Score (mHHS), a visual analog scale for sport activity–related pain (VAS-SRP), patient satisfaction, and ability and time to return to the preoperative sport level. Radiographic assessment was performed to determine recurrence. Results: The mean age of the patients was 32 years (range, 23-47 years). Mean follow-up was 44 months (range, 14-73 months). All patients had improved mHHS scores from a mean preoperative of 65.6 (SD, 8.2) to 93.9 (SD, 3.6). Pain decreased from a mean 8.2 preoperatively (SD, 0.9) to 0.4 (SD, 0.7) at last follow-up. There were no complications, and all patients were able to return to their previous sports at the same level except for 1 recreational athlete. There was only 1 radiological recurrence at last follow-up in an asymptomatic patient. Conclusion: To our knowledge, this is the largest case series of athletes with HORF treated with endoscopic resection. We found this extra-articular endoscopic technique to be safe and effective, showing clinical outcome improvement and 90% chance of return to full activity. We also found 10% recurrence rate of asymptomatic heterotopic ossification.
Association between poststroke epilepsy and death: A nationwide cohort study
Authors: Zelano Johan , Redfors Petra , Åsberg Signild , Kumlien Eva 
Published: September 2016

Introduction Poststroke epilepsy (PSE) is the most common form of acquired epilepsy after middle age. The primary aim of this study was to study the impact of PSE on prognosis. A secondary aim was to validate recent findings from smaller studies on the risk of developing PSE on a nationwide scale. Patients and methods We performed a nationwide cohort study based on comprehensive national registries and included patients without a prior epilepsy diagnosis surviving more than 2 months after stroke, identified by the Swedish Stroke Register (Riksstroke) and linked to the National Patient Register and Cause of Death Register. Cox proportional time-updated hazard model was used to assess the risk of death, with or without multivariable adjustment for possible confounders, and multiple Cox regression was used to examine associations between PSE and clinical characteristics. Results In 106,455 patients, PSE (defined as a seizure diagnosis more than 7 days after stroke) was detected in 7.3%, with lower cumulative incidence after ischemic stroke (6.4%) than after intracerebral haemorrhage (12.4%). Stroke severity, intracerebral haemorrhage and young age were associated with a risk of PSE. The risk of death was increased in patients with PSE (hazard ratio: 1.68, 95% confidence interval: 1.25–1.53). Also with adjustments for age, comorbidities and stroke severity, an increased risk of death associated with PSE remained. Discussion Studies are needed on potential causes of increased mortality in PSE, such as a direct seizure-related mortality, less ambitious secondary stroke prophylaxis or rehabilitation, or impact of antiepileptic drugs on cardiovascular risk.
Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease
Authors: Montenont Emilie , Echagarruga Christina , Allen Nicole , Araldi Elisa , Suarez Yajaira , Berger Jeffrey S. 
Published: September 2016

Key PointsPlatelet transcription of WDR1 suppresses platelet activity. Reduced transcription of WDR1 in platelets may be a link between elevated platelet activity and increased risk of cardiovascular disease.
Comparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks
Authors: Zhang Xiao-Fei , Ou-Yang Le , Dai Dao-Qing , Wu Meng-Yun , Zhu Yuan , Yan Hong 
Published: September 2016

AbstractBackgroundSeveral recent studies have used the Minimum Dominating Set (MDS) model to identify driver nodes, which provide the control of the underlying networks, in protein interaction networks. There may exist multiple MDS configurations in a given network, thus it is difficult to determine which one represents the real set of driver nodes. Because these previous studies only focus on static networks and ignore the contextual information on particular tissues, their findings could be insufficient or even be misleading.ResultsIn this study, we develop a Collective-Influence-corrected Minimum Dominating Set (CI-MDS) model which takes into account the collective influence of proteins. By integrating molecular expression profiles and static protein interactions, 16 tissue-specific networks are established as well. We then apply the CI-MDS model to each tissue-specific network to detect MDS proteins. It generates almost the same MDSs when it is solved using different optimization algorithms. In addition, we classify MDS proteins into Tissue-Specific MDS (TS-MDS) proteins and HouseKeeping MDS (HK-MDS) proteins based on the number of tissues in which they are expressed and identified as MDS proteins. Notably, we find that TS-MDS proteins and HK-MDS proteins have significantly different topological and functional properties. HK-MDS proteins are more central in protein interaction networks, associated with more functions, evolving more slowly and subjected to a greater number of post-translational modifications than TS-MDS proteins. Unlike TS-MDS proteins, HK-MDS proteins significantly correspond to essential genes, ageing genes, virus-targeted proteins, transcription factors and protein kinases. Moreover, we find that besides HK-MDS proteins, many TS-MDS proteins are also linked to disease related genes, suggesting the tissue specificity of human diseases. Furthermore, functional enrichment analysis reveals that HK-MDS proteins carry out universally necessary biological processes and TS-MDS proteins usually involve in tissue-dependent functions.ConclusionsOur study uncovers key features of TS-MDS proteins and HK-MDS proteins, and is a step forward towards a better understanding of the controllability of human interactomes.
A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells
Authors: Peffers Mandy J. , Collins John , Loughlin John , Proctor Carole , Clegg Peter D. 
Published: September 2016

Abstract
Background
Mesenchymal stem cells (MSCs) have prospective applications in regenerative medicine and tissue engineering but to what extent phenotype and differentiation capacity alter with ageing is uncertain. Consequently, any loss in functionality with age would have profound consequences for the maintenance of tissue viability and the quality of tissues. Proteomics enables the set of proteins responsible for a particular cell phenotype to be identified, as well as enabling insights into mechanisms responsible for age-related alterations in musculoskeletal tissues. Few proteomic studies have been undertaken regarding age-related effects on tissue engineered into cartilage and bone, and none for tendon. This study provides a proteome inventory for chondrogenic, osteogenic and tenogenic constructs synthesised from human MSCs, and elucidates proteomic alterations as a consequence of donor age.

Methods
Human bone-marrow derived MSCs from young (n = 4, 21.8 years ± 2.4SD) and old (n = 4, 65.5 years ± 8.3SD) donors were used to make chondrogenic, osteogenic and tenogenic tissue-engineered constructs. We utilised an analytical method relying on extracted peptide intensities as a label-free approach for peptide quantitation by liquid chromatography–mass spectrometry. Results were validated using western blotting.

Results
We identified proteins that were differentially expressed with ageing; 128 proteins in chondrogenic constructs, 207 in tenogenic constructs and four in osteogenic constructs. Differentially regulated proteins were subjected to bioinformatic analysis to ascertain their molecular functions and the signalling pathways. For all construct types, age-affected proteins were involved in altered cell survival and death, and antioxidant and cytoskeletal changes. Energy and protein metabolism were the principle pathways affected in tenogenic constructs, whereas lipid metabolism was strongly affected in chondrogenic constructs and mitochondrial dysfunction in osteogenic constructs.

Conclusions
Our results imply that further work on MSC-based therapeutics for the older population needs to focus on oxidative stress protection. The differentially regulated proteome characterised by this study can potentially guide translational research specifically aimed at effective clinical interventions.
Advances in biodiversity: metagenomics and the unveiling of biological dark matter
Authors: Robbins Robert J. , Krishtalka Leonard , Wooley John C. 
Published: September 2016

Abstract
Background
Efforts to harmonize genomic data standards used by the biodiversity and metagenomic research communities have shown that prokaryotic data cannot be understood or represented in a traditional, classical biological context for conceptual reasons, not technical ones.

Results
Biology, like physics, has a fundamental duality—the classical macroscale eukaryotic realm vs. the quantum microscale microbial realm—with the two realms differing profoundly, and counter-intuitively, from one another. Just as classical physics is emergent from and cannot explain the microscale realm of quantum physics, so classical biology is emergent from and cannot explain the microscale realm of prokaryotic life. Classical biology describes the familiar, macroscale realm of multi-cellular eukaryotic organisms, which constitute a highly derived and constrained evolutionary subset of the biosphere, unrepresentative of the vast, mostly unseen, microbial world of prokaryotic life that comprises at least half of the planet’s biomass and most of its genetic diversity. The two realms occupy fundamentally different mega-niches: eukaryotes interact primarily mechanically with the environment, prokaryotes primarily physiologically. Further, many foundational tenets of classical biology simply do not apply to prokaryotic biology.

Conclusions
Classical genetics one held that genes, arranged on chromosomes like beads on a string, were the fundamental units of mutation, recombination, and heredity. Then, molecular analysis showed that there were no fundamental units, no beads, no string. Similarly, classical biology asserts that individual organisms and species are fundamental units of ecology, evolution, and biodiversity, composing an evolutionary history of objectively real, lineage-defined groups in a single-rooted tree of life. Now, metagenomic tools are forcing a recognition that there are no completely objective individuals, no unique lineages, and no one true tree. The newly revealed biosphere of microbial dark matter cannot be understood merely by extending the concepts and methods of eukaryotic macrobiology. The unveiling of biological dark matter is allowing us to see, for the first time, the diversity of the entire biosphere and, to paraphrase Darwin, is providing a new view of life. Advancing and understanding that view will require major revisions to some of the most fundamental concepts and theories in biology.
SISTEMA DE GESTÃO DA QUALIDADE NO INSTITUTO BIOLÓGICO (SP): RELATO DA TRANSIÇÃO DA NBR ISO 9001 PARA NBR ISO/ IEC 17025
Authors: Vitiello Nayte , Miyashiro Simone , Galleti Silvia Regina , Vieira Martiniana Da Silva , Nascimento Elizabeth Souza , Batista Filho Antonio 
Published: September 2016

Nos últimos anos, laboratórios de instituições públicas que atuam em sanidade vêm padronizando seus ensaios com a finalidade de atender à demanda internacional dos agronegócios. Esse fenômeno vem provocando mudança da cultura organizacional com vistas à melhoria da rotina, rastreabilidade e credibilidade dos resultados das análises. Contudo, o processo de implantação e implementação pode ser comprometido pelos custos relacionados a insumos e calibração dos equipamentos, bem como à falta de tempo e dedicação do pessoal especializado. Este trabalho tem como objetivo relatar o processo de transição da norma ISO 9001 para a ISO/ IEC 17025 em laboratórios com o mesmo perfil de serviço. Três laboratórios foram avaliados no processo de transição. Os avanços da implantação da ISO/IEC 17025 foram comprovados pela análise documentária, contextualização, auditorias e questionário. Verificou-se que laboratórios com sistema de gestão de qualidade implantado em normas mais genéricas apresentaram mais facilidade de implantar e implementar normas técnicas.
Development of Ideas of Math Education of Younger Schoolchildren in Soviet School in 30-50-ies of the XX Century
Authors: Кочурова  , Kochurova Elena 
Published: September 2016

The article deals with the developmental dynamics of the methods of mathematical education in one of the most important periods of the
formation of a primary school in our country. The author describes the positive aspects in the development of primary education, reveals the flaws
and contradictions. The detailed review of all components of methodical system is given: objectives, content, methods, means of mathematical
formation of younger schoolchildren.
Dynamic Conditional Beta Is Alive and Well in the Cross Section of Daily Stock Returns
Authors: Bali Turan G. , Engle Robert F. , Tang Yi 
Published: September 2016

This paper presents evidence for a significantly positive link between the dynamic conditional beta and the cross section of daily stock returns. An investment strategy that takes a long position in stocks in the highest conditional beta decile and a short position in stocks in the lowest conditional beta decile produces average returns and alphas in the range of 0.60%–0.80% per month. We provide an investor attention-based explanation of this finding. We show that stocks with high conditional beta have strong attention-grabbing characteristics, leading to a higher fraction of buyer-initiated trades for these stocks. We also find that stocks recently bought perform significantly better than stocks recently sold. Hence, the high beta stocks that investors are more likely to buy have higher expected returns than the low beta stocks that investors are more likely to sell. This paper was accepted by Lauren Cohen, finance.