bluuebunny/crossref_metadata_2025_split huggingface dataset:
М.М. Аркас і збереження історичної пам’яті про Т.Г. Шевченка (остання чверть 19 – початок 20 ст.)
Authors: Svitlenko Serhiy 
Published: September 2024

Мета статті полягає в історичній реконструкції різнобічної діяльності М.М. Аркаса у справі збереження історичної пам’яті про Т.Г. Шевченка в останній чверті 19 – на початку 20 ст.
Наукова новизна. Здійснено концептуальне осмислення теми, показано ґенезу інтересу М.М. Аркаса до постаті Т.Г. Шевченка за контроверсійних суспільно-політичних чинників. Доведено, що увічнення в історичній пам’яті образу Т.Г. Шевченка являло собою в діяльності М.М. Аркаса органічний триєдиний процес у межах українського національного культурництва, виявлено його смисли, структуру, зокрема три основні напрями. Вказано на зв’язок інтелектуальної меморіалізації історичної пам’яті про Т.Г. Шевченка з образом мислення, ціннісними поглядами, ідеалами, орієнтаціями, традиціями свідомого українства.
Висновки. Збереження історичної пам’яті про Т.Г. Шевченка стало важливим змістом життя та діяльності М.М. Аркаса за несприятливих історичних умов російського імперського режиму та світоглядного впливу українського народолюбства. Увічнення історичної пам’яті Кобзаря у діяльності М.М. Аркаса здійснювалося модусами українського культурництва – маркерами його української національної свідомості й ідентичності.
Основними смислами та напрямами вшанування особистості Кобзаря в інтелектуальній діяльності та громадських практиках М.М. Аркаса стали засоби музично-театрального мистецтва, популярного історичного наративу та громадської просвітянської діяльності. Як щирий український патріот М.М. Аркас відігравав ключову роль у започаткуванні феномену Шевченківських роковин у Миколаєві. Це відбивалося у діяльності українських гуртків і Миколаївської «Просвіти» періоду 1902-1909 рр. Імперський режим чинив всілякий спротив увічненню світлого образу Кобзаря. Традиція вшанування історичної пам’яті Т.Г. Шевченка у Миколаєві, закладена М.М. Аркасом, мала послідовників і стала ознакою необоротного ментального розриву з «єдиним російським світом» у колах свідомого українства, сприяла його консолідації, утвердженню національної свідомості та ідентичності.
Application of neural network adaptive filter method to simultaneous detection of polymetallic ions based on ultraviolet-visible spectroscopy
Authors: Wu Bo , Zhou Fengbo 
Published: September 2024

A novel neural network adaptive filter algorithm is proposed to address the challenge of weak spectral signals and low accuracy in micro-spectrometer detection. This algorithm bases on error backpropagation (BP) and least mean square (LMS), introduces an innovative BP neural network model incorporating instantaneous error function and error factor to optimize the learning process. It establishes a network relationship through the input signal, output signal, error and step factor of the adaptive filter, and defines a training optimization learning method for this relationship. To validate the effectiveness of the algorithm, experiments were conducted on simulated noisy signals and actual spectral signals. Results show that the algorithm effectively denoises signals, reduces noise interference, and enhances signal quality, the SNR of the proposed algorithm is 3–4 dB higher than that of the traditional algorithm. The experimental spectral results showed that the proposed neural network adaptive filter algorithm combined with partial least squares regression is suitable for simultaneous detection of copper and cobalt based on ultraviolet-visible spectroscopy, and has broad application prospects.
Auricular pressure as an adjuvant treatment for type 2 diabetes: data mining and meta-analysis
Authors: Yu Yunfeng , Xiang Qin , Liu Xiu , Yin Yuman , Bai Siyang , Yu Rong 
Published: September 2024

ObjectiveThis study aimed to explore the clinical efficacy and acupoint combinations of auricular pressure for treating type 2 diabetes.MethodsEight common databases were searched for publications related to auricular pressure in type 2 diabetes as of November 2023. A meta-analysis was performed to assess the efficacy and safety of auricular pressure therapy. Data mining was used to analyze the core acupoints for auricular pressure.ResultsMeta-analysis demonstrated that compared with the conventional treatment group, the combined auricular pressure and conventional treatment group had significantly reduced fasting blood glucose (mean difference [MD]: -0.93; 95% confidence interval [CI]: -1.17 to -0.68; p &lt; 0.00001), 2-hour postprandial blood glucose (MD: -1.58; 95% CI: -2.04 to -1.12; p &lt; 0.00001), glycated hemoglobin A1c (MD: -0.83; 95% CI: -1.19 to -0.48; p &lt; 0.00001), total cholesterol (MD: -0.43; 95% CI: -0.72 to -0.14; p = 0.004), triglycerides (MD: -0.33; 95% CI: -0.64 to -0.03; p &lt; 0.00001), systolic blood pressure (MD: -14.75; 95% CI: -24.46 to -5.05; p = 0.003), diastolic blood pressure (MD: -10.32; 95% CI: -20.14 to -0.50; p = 0.04), and body mass index (MD: -1.74; 95% CI: -2.61 to -0.87; p &lt; 0.0001), while adverse events were comparable (RR: 0.84; 95% CI: 0.43 to 1.66; p = 0.61). Egger’s test revealed no publication bias (p = 0.715). Data mining identified AH6a, TF4, AT4, CO18, and CO10 as core acupoints for treating type 2 diabetes with auricular pressure.ConclusionAuricular pressure safely improves blood glucose and lipid levels, blood pressure, and body mass index in patients with type 2 diabetes. A regimen consisting of AH6a, TF4, AT4, CO18, and CO10 is expected to serve as a complementary treatment for type 2 diabetes.Systematic review registrationwww.crd.york.ac.uk/prospero/display_record.php?RecordID=524887, identifier CRD42024524887.
Development and clinical validation of a novel detection kit for α-thalassemia in southern Chinese
Authors: Ge Yi-Yuan , Xie Jun , Liao Yu-Wei , Xie Long-Xu , Yang Li-Ye 
Published: September 2024

ObjectiveThis study aimed to develop and assess a novel reverse dot blot assay for the simultaneous detection of 10 types of α-thalassemia alleles in the Chinese population, including six common variants of–SEA, -α3.7, -α4.2, αCS, αQS, and αWS, and four rare variants of αααanti−4.2, αααanti−3.7, --FIL deletion and--THAI deletion.MethodsThe novel thalassemia gene assay utilized a two-tier multiplex polymerase chain reaction amplification system and one round of hybridization. Genomic DNA samples were sourced from three hospitals in southern China. Each clinically validated DNA sample was re-evaluated using the new multiplex polymerase chain reaction/reverse dot blot assay Ⅲ (M-PCR/RDB Ⅲ).ResultsThe study analyzed a total of 1,148 unrelated participants, consisting of 810 thalassemia patients and 338 healthy control subjects. Valid hybridization results were obtained for 1,147 samples, with one case (thalassemia carrier) being excluded from the study due to the poor quality of DNA. All 1,147 samples, including those with α heterozygous thalassemia, α homozygous thalassemia, α compound heterozygous thalassemia, and control subjects were accurately genotyped, showing 100% concordance with the reference assays.ConclusionThe novel M-PCR/RDB Ⅲ assay proved to be simple, rapid, and precise, indicating its potential for genetic screening and clinical diagnosis of both common and rare α-thalassemia variants in Chinese populations.
Seasonal changes of plankton community and its influencing factors in subtropical coastal marine areas revealed by eDNA-based network analysis
Authors: Lin Xiaoqi , Li Kunhuan , Zhao Hancheng , Gao Yan , Zhang Zonghang , Wang Lin , Wang Xinjie , Sanganyado Edmond , Zheng Zhao , Gutang Qilin , Liu Sailan , Li Ping , Yan Xiuli , Chen Zhaoyun , Lin Jianqing , Liu Wenhua 
Published: September 2024

IntroductionCoastal marine ecosystems are among the most ecologically and socio-economically dynamic regions on Earth, and the study of eukaryotic planktonic communities is an important aspect of aquatic ecology. It is essential to monitor plankton biodiversity and identify influencing factors in order to measure human effects on coastal waters and help contribute to ecosystem preservation. Environmental DNA (eDNA) metabarcoding analysis is an advanced toolfor detecting the presence of aquatic organisms, which has revolutionary significance for biodiversity monitoring and real-time detection of wild environments.MethodsIn this study, eDNA metabarcoding was used to study seasonal changes in eukaryotic plankton communities in subtropical coastal waters of the northern South China Sea, to explore how various trophic groups affect the complexity and stability of the species network.ResultsThe results showed that the summer interaction network is looser and had has reduce biodiversitycompared to the spring interaction network. As an important part of the planktonic community, the abundance and diversity of algae reflect the interactions between different species and the influence of environmental factors on the dominant species, particularly temperature and nutrients. In addition, producer diversity set the basis for species network complexity and indirectly affected network stability, while consumer diversity and its flexible predation strategies may directly lead to differences in network stability across seasons. There were close correlations among species interaction, environmental factors and species diversity.DiscussionThis study can help us understand the ecosystem functions throughout the year and the complex interactions of planktonic communities from a multiple trophic level perspective, and provide effective methods for sustainable resource utilization and ecological environmental protection in the future.
Observations of the efficacy of the artificial lens cushion plate technique in hard-core cataract surgery
Authors: Huang ZhiQing , Zheng MiYun , Xu MaoDong , Cai Lei , Song XiaoQing 
Published: September 2024

ObjectiveTo evaluate the efficacy of intraocular lens (IOL) cushion plate technology in reducing corneal endothelial cell loss during hard-core cataract surgery compared with conventional ultrasonic emulsification.MethodsSeventy-six patients with hard-core cataracts who underwent surgery at our institution from April 2019 to June 2022 were included. The patients were divided into an observation group (IOL cushion plate technology, 38 patients) and a control group (conventional ultrasonic emulsification, 38 patients). Surgical outcomes, including the corneal endothelial cell loss rate, best corrected visual acuity (BCVA), and central corneal thickness (CCTc), were compared between the two groups.ResultsPreoperative patient characteristics were similar between the groups. Postoperatively, both groups demonstrated similar BCVA and CCTc values on days 7 and 30. However, compared with the observation group, the control group presented a significantly greater rate of corneal endothelial cell loss on postoperative days 7 and 30 (p &lt; 0.05). Intraoperative complications and postoperative complications were notably greater in the control group (p &lt; 0.05). The observation group had reduced ultramilk time and total energy consumption (p &lt; 0.05).ConclusionIOL cushion plate technology offers advantages in preserving corneal endothelial cells during hard-core cataract surgery, potentially improving surgical safety and efficacy.
Association of autoimmune diseases with the occurrence of osteoarthritis: a gene expression and Mendelian randomization study
Authors: Dan Jing , Lu Huai Min , Zhou Xun , Wang Hong Yuan , Wang Jia Hao 
Published: September 2024

BackgroundObservational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk of mortality among affected patients. However, whether a causal relationship exists between the two remains unknown.MethodsIn the Mendelian randomization (MR) study, we accessed exposure Genome-wide association study (GWAS) data from both the MRC Integrative Epidemiology Unit (MRC-IEU) and the FinnGen consortium. GWAS data for OA were obtained from MRC-IEU. We employed univariable, multivariable, and reverse MR analyses to explore potential associations between autoimmune disorders and OA. Additionally, a two-step mediation MR analysis was performed to investigate indirect factors possibly influencing the relationship between autoimmune disorders and OA. Afterward, we conducted an observational analysis to further explore the relationship between autoimmune disease and occurrence as well as of OA using a real-world database (the MIMIC-IV database). Based on public gene expression sequencing data, we further explored the potential shared pathogenesis between autoimmune diseases and OA.ResultsIn our univariable MR study, we identified five autoimmune diseases that are associated with OA. These include Celiac disease (OR = 1.061, 95% CI = 1.018–1.105, p = 0.005), Crohn’s disease (OR = 1.235, 95% CI = 1.149–1.327, p = 9.44E-09), Ankylosing spondylitis (OR = 2.63, 95% CI = 1.21–5.717, p = 0.015), RA (OR = 1.082, 95% CI = 1.034–1.133, p = 0.001), and Ulcerative colitis (OR = 1.175, 95% CI = 1.068–1.294, p = 0.001). In the mediation effect analysis, it was found that there is no correlation between cytokines and autoimmune diseases and OA. Based on transcriptome data analysis, it was found that metabolism-related pathways play a key role in the co-morbidity of autoimmune diseases and OA.ConclusionOur findings revealed that genes associated with Celiac disease, Crohn’s disease, Ankylosing spondylitis, RA, and Ulcerative colitis were independently linked to the development of OA. Furthermore, we conducted an analysis of potential pathogenic genes between these diseases and OA, offering a novel approach for the simultaneous treatment of multiple conditions.
Acceptance of family doctors among residents in China: a cross-sectional study
Authors: Feng Jing , Lei Zihui , Li Xinyan , Qu Ge , Sun Yuchao , Zheng Yanling , Zuo Yanli , Gan Yong , Ye Jun 
Published: September 2024

ObjectivesThis study aimed to investigate the level of acceptance of family doctors (FDs) exhibited by residents in China.MethodsA cross-sectional study based on a structured self-administered questionnaire was conducted to investigate residents in eastern, central, and western China between September and December 2021. A multivariable stepwise logistic regression model was employed to identify the factors associated with health-seeking behavior after the signing of agreements concerning family doctor contract services (FDCS) as well as residents’ willingness to change FDs.ResultsAmong the 2,394 respondents included in this research, 55.8% sought primary care from their FDs when they became ill, whereas 9.7% expressed a willingness to change FDs. Residents who reported high levels of satisfaction with FDCS [odds ratio (OR) = 2.162] and trust in FDs (OR = 1.430) were more likely to seek initial help from FDs. In addition, residents from central China (OR = 0.546) and western China (OR = 0.704) and those who exhibited a high level of trust in FDs (OR = 0.238) were less likely to change FDs.ConclusionThe level of FD acceptance among Chinese residents was relatively high. Satisfaction with FDCS and trust in FDs were associated with the acceptance of FDs among residents. FDs should make efforts to enhance the quality of health services as well as the overall health experience of residents.
Baseline prognostic predictors in classical Hodgkin Lymphoma: a retrospective, single-center analysis on patients treated with PET/CT-guided ABVD
Authors: Cellini Alessandro , Cavarretta Chiara Adele , Angotzi Francesco , Ruocco Valeria , Serafin Andrea , Danesin Nicolò , Pizzi Marco , Gregianin Michele , Vio Stefania , Crimì Filippo , Vianello Federica , Piazza Francesco , Trentin Livio , Visentin Andrea 
Published: September 2024

IntroductionThe identification of baseline prognostic factors in Classical Hodgkin Lymphoma could help in tailoring a risk-based approach as the therapeutic landscape expands. Currently, the International Prognostic Score (IPS) represents the most used prediction tool in clinical practice, but other potential baseline risk predictors have been identified.MethodsWe performed a retrospective analysis in a cohort of 274 patients treated with 18FDG-PET/CT-guided ABVD to assess the prognostic significance of the IPS risk factors, and to validate the impact of the peripheral blood lymphocyte to monocyte (LMR) and neutrophil to lymphocyte (NLR) ratios on prognosis definition.ResultsAmong the considered risk factors, stage IV disease (HR 1.83), leukocytosis (HR 2.28), anemia (HR 3.23) and low LMR (HR 2.01) significantly predicted PFS, whereas male sex (HR 2.93), stage IV disease (HR 3.00) and lymphopenia (HR 7.84) significantly predicted OS. A 4 variable and a 3 variable prognostic system was subsequently proposed for PFS and OS, respectively. In both cases, a stark decrease in the survival probability was documented as the score increased. Moreover, by selecting only the significant IPS items and considering a more recently proposed prognostic factor (LMR) we were able to better identify patients at higher risk of relapsing after PET/CT-guided ABVD.DiscussionAlthough the IPS was still able to identify a subgroup of high-risk patients within our cohort of individuals treated with PET/CT-guided ABVD, not all the risk factors that it considers were found to have an impact on survival times. Moreover, by selecting only the significant IPS items and considering a more recently proposed prognostic factor (LMR) we were able to better identify patients at higher risk of relapse, in an effort to contribute to the building of a modern risk prediction tool that can help guide treatment choices.
Assessing the role of advanced artificial intelligence as a tool in multidisciplinary tumor board decision-making for recurrent/metastatic head and neck cancer cases – the first study on ChatGPT 4o and a comparison to ChatGPT 4.0
Authors: Schmidl Benedikt , Hütten Tobias , Pigorsch Steffi , Stögbauer Fabian , Hoch Cosima C. , Hussain Timon , Wollenberg Barbara , Wirth Markus 
Published: September 2024

BackgroundRecurrent and metastatic head and neck squamous cell carcinoma (HNSCC) is characterized by a complex therapeutic management that needs to be discussed in multidisciplinary tumor boards (MDT). While artificial intelligence (AI) improved significantly to assist healthcare professionals in making informed treatment decisions for primary cases, an application in the even more complex recurrent/metastatic setting has not been evaluated yet. This study also represents the first evaluation of the recently published LLM ChatGPT 4o, compared to ChatGPT 4.0 for providing therapy recommendations.MethodsThe therapy recommendations for 100 HNSCC cases generated by each LLM, 50 cases of recurrence and 50 cases of distant metastasis were evaluated by two independent reviewers. The primary outcome measured was the quality of the therapy recommendations measured by the following parameters: clinical recommendation, explanation, and summarization.ResultsIn this study, ChatGPT 4o and 4.0 provided mostly general answers for surgery, palliative care, or systemic therapy. ChatGPT 4o proved to be 48.5% faster than ChatGPT 4.0. For clinical recommendation, explanation, and summarization both LLMs obtained high scores in terms of performance of therapy recommendations, with no significant differences between both LLMs, but demonstrated to be mostly an assisting tool, requiring validation by an experienced clinician due to a lack of transparency and sometimes recommending treatment modalities that are not part of the current treatment guidelines.ConclusionThis research demonstrates that ChatGPT 4o and 4.0 share a similar performance, while ChatGPT 4o is significantly faster. Since the current versions cannot tailor therapy recommendations, and sometimes recommend incorrect treatment options and lack information on the source material, advanced AI models at the moment can merely assist in the MDT setting for recurrent/metastatic HNSCC.
Persistence of pain and suffering in cancer patients: challenges of pain management from the perspective of nurses
Authors: Mangolian Shahrbabaki Parvin , Farokhzadian Jamileh , Ahmadi Fazlollah , Khabbazzadeh Fatemeh 
Published: September 2024

PurposeCancer patients often experience pain, which can greatly reduce their quality of life. It affects their emotions, cognitive function, and daily interactions. Healthcare providers need to understand the obstacles to pain management to create helpful programs for patients and families. This study focuses on Iranian nurses' views on pain management barriers in cancer patients.MethodsThe study utilized a qualitative content analysis method with a purposive sampling approach, involving 27 nurses. Participants were selected to ensure a wide range of perspectives and experiences by considering factors such as gender, age, work experience, education levels, and positions until data saturation was achieved. Inclusion criteria specified a minimum of six months of oncology ward experience and a bachelor's degree or higher in nursing. Nurses with less than six months of oncology experience or lacking a nursing degree were excluded. Data collection was conducted through semi-structured interviews and analyzed using Lundman and Granheim's qualitative content analysis method.ResultsOne main theme, four main categories, and nine subcategories in the study reflected the nurses' experiences and viewpoints about barriers to pain management. These categories included the marginalization of complementary medicine, medical malpractice, inadequate organizational infrastructure, and personal barriers.ConclusionThe study demonstrated that the barriers to pain management in cancer patients were complex. To improve patients' comfort and quality of life, it is important to identify and address issues from different angles. It is crucial to train patients and healthcare providers in pain management and to address weaknesses in the healthcare system.
A qualitative analysis of parents’ experiences while their neonates with congenital heart disease require intensive care
Authors: Catapano Francesca , Steinwurtzel Rochelle , Parravicini Elvira , Wool Charlotte 
Published: September 2024

ObjectiveTo better understand the experience of parents with neonates with congenital heart diseases (CHD) admitted to a neonatal intensive care unit (NICU) in order to identify challenges faced by parents and discover support strategies helpful in positive coping.Study designProspective cohort study of parents of neonates with CHD. Parents completed a questionnaire with open ended questions regarding their experience and feeling during the hospitalization within one week of the child discharge from the NICU. Krippendorff's content analysis was used to examine data.ResultsSixty-four parents participated. Three themes were highlighted – Dialectical parental experiences, Suboptimal Parental Experiences and Positive Parental Experiences – describing the state of being and feelings that these parents face. Through this analysis, we were able to develop clinical considerations and identify coping strategies.ConclusionThe understanding of parental experience and challenges when dealing with their child admitted in the NICU is crucial to identify coping strategies to promote adaptation and enhance the development of positive coping mechanisms.