bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface modification of metal mesh with SiO2 films for enhanced corrosion protection
Authors: Zhang Ting , Sai Huazheng , Guan Yunlong , Fu Rui , Yang Hu , Jia Huanhuan , Yue Xian , Xiang Junhui 
Published: June 2017

AbstractSiO2 film coatings were used to modify the surface of metal mesh for corrosion protection using liquid phase deposition and sol‐gel methods at low temperature. Different techniques were applied to characterized the as‐prepared samples. The results show an enhanced corrosion protection of the SiO2 deposited samples in comparison to the unmodified samples, as well as the SiO2 deposited sample prepared with sol gel method provides the better corrosion protection when compared with the liquid phased deposited sample, which mainly contributes to its compact morphology. The hydrophobic SiO2 coatings also exhibit excellent corrosion resistance since hydrophobic modification can hinder the contact with environment.
Digital transformation by SME entrepreneurs: A capability perspective
Authors: Li Liang , Su Fang , Zhang Wei , Mao Ji‐Ye 
Published: June 2017

AbstractThis research investigates how entrepreneurs of small and medium enterprises (SMEs) with inadequate capabilities and limited resources drove digital transformation in their companies, a phenomenon that remains under‐researched in the extant literature. We conduct qualitative research on digital transformation to cross‐border e‐commerce undergone by 7 SMEs on the Alibaba digital platform. We inductively derive a process model that aims to describe and explain how SME entrepreneurs, with support from the digital platform service provider, drive digital transformation through managerial cognition renewal, managerial social capital development, business team building, and organizational capability building. This model expands our understanding of both digital entrepreneurship and digital transformation. It also presents new insights into how digital platform service providers can help SMEs transform and compete.
An integrative review of multicomponent weight management interventions for adults with intellectual disabilities
Authors: Doherty Alison J. , Jones Stephanie P. , Chauhan Umesh , Gibson Josephine M. E. 
Published: June 2017

BackgroundObesity is more prevalent in people with intellectual disabilities and increases the risk of developing serious medical conditions. UK guidance recommends multicomponent weight management interventions (MCIs), tailored for different population groups.MethodsAn integrative review utilizing systematic review methodology was conducted to identify the types of MCIs delivered to adults with intellectual disabilities.FindingsFive studies were identified. All of the studies' MCIs were tailored for adults with intellectual disabilities. Tailoring included measures such as simplified communication tools, individualized sessions, and the presence of carers where appropriate.ConclusionsEmerging evidence suggests ways in which MCIs can be tailored for adults with intellectual disabilities but, given the few studies identified, it is not possible to recommend how they can be routinely tailored. Further studies are justified for adults with intellectual disabilities at risk of obesity‐related conditions.
Comparison of thiazide‐like diuretics versus thiazide‐type diuretics: a meta‐analysis
Authors: Liang Wenjing , Ma Hui , Cao Luxi , Yan Wenjiang , Yang Jingjing 
Published: June 2017

AbstractThiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide‐type diuretics hydrochlorothiazide and thiazide‐like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta‐analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol. Twelve trials were identified: five based on the comparison of indapamide versus hydrochlorothiazide and seven based on the chlorthalidone versus hydrochlorothiazide. In the meta‐analysis of blood pressure reduction, thiazide‐like diuretics seemed to further reduce systolic BP ([95% CI]; −5.59 [−5.69, −5.49]; P < 0.001) and diastolic BP ([95% CI]; −1.98 [−3.29, −0.66]; P = 0.003). Meanwhile, in the analysis of side effects, the incidence of hypokalemia ([95% CI]; 1.58 [0.80, 3.12]; P = 0.19), hyponatremia ([95% CI]; −0.14 [−0.57, 0.30], P = 0.54), change of blood glucose ([95% CI];0.13 [−0.16, 0.41], P = 0.39) and total cholesterol ([95% CI]; 0.13 [−0.16, 0.41], P = 0.39) showed that there is no statistical significant differences between the two groups of drugs. In conclusion, using thiazide‐like diuretics is superior to thiazide‐type diuretics in reducing blood pressure without increasing the incidence of hypokalemia, hyponatraemia and any change of blood glucose and serum total cholesterol.
Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE−/−/LDLR−/− mouse via a PPARγ/CD36 pathway
Authors: Wang Feng , Han Lu , Qin Ran‐ran , Zhang Yao‐yuan , Wang Di , Wang Zhi‐Hao , Tang Meng‐Xiong , Zhang Yun , Zhong Ming , Zhang Wei 
Published: June 2017

AbstractThe aim of this study was to investigate whether overexpression of STAMP2 improves insulin resistance by regulating angiogenesis in adipose tissues. The characteristics of diabetic mice were measured by serial metabolite and pathology tests. Samples were obtained from epididymal, subcutaneous and brown adipose tissues. Histological and morphological analysis demonstrated that STAMP2 gene overexpression reduced adipocyte size, angiogenesis in epididymal and brown adipose tissues. On aortic ring assay, microvessels sprouting from aortas were significantly inhibited after STAMP2 gene overexpression. The cellular effect of STAMP2 on angiogenesis was explored in human umbilical vein endothelial cells (HUVECs) model. Correlation of STAMP2 and angiogenesis was validated by Ad‐STAMP2 transfection and STAMP2 siRNA inhibition. In vitro, overexpression of STAMP2 significantly inhibited endothelial cell migration, tube formation. The effects of Ad‐STAMP2 transfection on HUVECs were abolished by treatment with PPARγ antagonist GW9662 (2.5 μM), and the roles of STAMP2 siRNA on HUVECs were also reversed by treatment with PPARγ agonist rosiglitazone (RSG) (0.1 mM). RT‐PCR indicated that STAMP2 could regulate levels of adhesion molecules, vascular endothelial growth factor A and CD36. The expression of PPARγ and CD36 was decreased when STAMP2 was inhibited by siRNA, while PPARγ and CD36 were highly expressed after overexpression of STAMP2. Our results suggested that STAMP2 gene overexpression may improve insulin resistance via attenuating angiogenesis in epididymal and brown adipose tissues through the PPARγ/CD36 signalling pathway.
State of the art technologies to explore long non‐coding RNAs in cancer
Authors: Salehi Saeede , Taheri Mohammad Naser , Azarpira Negar , Zare Abdolhossein , Behzad‐Behbahani Abbas 
Published: June 2017

AbstractLong non‐coding RNAs (lncRNAs) comprise a vast repertoire of RNAs playing a wide variety of crucial roles in tissue physiology in a cell‐specific manner. Despite being engaged in myriads of regulatory mechanisms, many lncRNAs have still remained to be assigned any functions. A constellation of experimental techniques including single‐molecule RNA in situ hybridization (sm‐RNA FISH), cross‐linking and immunoprecipitation (CLIP), RNA interference (RNAi), Clustered regularly interspaced short palindromic repeats (CRISPR) and so forth has been employed to shed light on lncRNA cellular localization, structure, interaction networks and functions. Here, we review these and other experimental approaches in common use for identification and characterization of lncRNAs, particularly those involved in different types of cancer, with focus on merits and demerits of each technique.
MicroRNA‐containing extracellular vesicles released from endothelial colony‐forming cells modulate angiogenesis during ischaemic retinopathy
Authors: Dellett Margaret , Brown Eoin D. , Guduric‐Fuchs Jasenka , O'Connor Anna , Stitt Alan W. , Medina Reinhold J. , Simpson David A. 
Published: June 2017

AbstractEndothelial colony‐forming cells (ECFCs) are a defined subtype of endothelial progenitors that modulate vascular repair and promote perfusion in ischaemic tissues. Their paracrine activity on resident vasculature is ill‐defined, but mediated, at least in part, by the transfer of extracellular vesicles (EVs). To evaluate the potential of isolated EVs to provide an alternative to cell‐based therapies, we first performed a physical and molecular characterization of those released by ECFCs. Their effects upon endothelial cells in vitro and angiogenesis in vivo in a model of proliferative retinopathy were assessed. The EVs expressed typical markers CD9 and CD63 and formed a heterogeneous population ranging in size from ~60 to 1500 nm by electron microscopy. ECFC EVs were taken up by endothelial cells and increased cell migration. This was reflected by microarray analyses which showed significant changes in expression of genes associated with angiogenesis. Sequencing of small RNAs in ECFCs and their EVs showed that multiple microRNAs are highly expressed and concentrated in EVs. The functional categories significantly enriched for the predicted target genes of these microRNAs included angiogenesis. Intravitreally delivered ECFC EVs were associated with the vasculature and significantly reduced the avascular area in a mouse oxygen‐induced retinopathy model. Our findings confirm the potential of isolated EVs to influence endothelial cell function and act as a therapy to modulate angiogenesis. The functions associated with the specific microRNAs detected in ECFC EVs support a role for microRNA transfer in mediating the observed effects.
Studies on the occurrence of infectious myonecrosis virus in pond‐reared Litopenaeus vannamei (Boone, 1931) in India
Authors: Sahul Hameed A S , Abdul Majeed S , Vimal S , Madan N , Rajkumar T , Santhoshkumar S , Sivakumar S 
Published: June 2017

AbstractWhiteleg shrimp, Litopenaeus vannamei, with clinical sign of muscle opaqueness with reddish colour at the distal abdominal segments were observed in farms located in West Bengal State, India. The mortality of shrimp in all disease outbreak ponds ranged from 20% to 50%, and mortality increased gradually. The RT‐PCR assay of these samples using primer sets specific to infectious myonecrosis virus (IMNV) revealed its presence in the disease outbreak ponds. The IMNV infection was reproduced in healthy shrimp by intramuscular injection to satisfy River's postulates. The virus caused mortality in intramuscularly challenged shrimp, but failed to cause mortality by oral route. Tissue distribution of IMNV in infected shrimp by RT‐PCR assay revealed the presence of this virus in haemolymph, gill, hepatopancreas and muscle. This study confirms that the disease outbreak which occurred in the shrimp farms located at Purba Medinipur District, West Bengal, India, was due to IMNV.
Modeling rice and corn hydration kinetic by Nicolin–Jorge model
Authors: Nicolin Douglas Junior , Marques Barbara Celuppi , Balbinoti Thaisa Carvalho Volpe , Jorge Regina Maria Matos , Jorge Luiz Mario de Matos 
Published: June 2017

AbstractThis article presents the application of Nicolin–Jorge model in describing the hydration kinetics of rice and corn grains. The model was validated by hydration data of both grains for different hydration temperatures. The results show a satisfactory adequacy of the model to the data, even applying the data to the cylindrical and planar geometries, since the original model was proposed to describe the soybean hydration kinetics, considered spherical. Even as the parameters fitted for both cases have behaved differently depending on the temperature, the model predicted properly the reach of equilibrium moisture for very long hydration times.Practical applicationsThe approach presented in this article is useful in describing the moisture absorption kinetics by rice and corn grains. The model applied fits satisfactorily the experimental data and is applicable when the hypothesis of constant mass transfer coefficient in moisture absorption is not enough to correctly describe the behavior of the kinetic curve of moisture as a function of time for such grains. The proposed approach is applicable to any project that requires prior knowledge of the moisture profile of the grains. The advantage of the model used is the simplicity of the analytical solution obtained and that the model possesses physical grounds, although the grains are considered to be a lumped parameter system, which is an adequate consideration for practical applications.
ZYGOTE‐ARREST 3 that encodes the tRNA ligase is essential for zygote division in Arabidopsis
Authors: Yang Ke‐Jin , Guo Lei , Hou Xiu‐Li , Gong Hua‐Qin , Liu Chun‐Ming 
Published: June 2017

AbstractIn sexual organisms, division of the zygote initiates a new life cycle. Although several genes involved in zygote division are known in plants, how the zygote is activated to start embryogenesis has remained elusive. Here, we showed that a mutation in ZYGOTE‐ARREST 3 (ZYG3) in Arabidopsis led to a tight zygote‐lethal phenotype. Map‐based cloning revealed that ZYG3 encodes the transfer RNA (tRNA) ligase AtRNL, which is a single‐copy gene in the Arabidopsis genome. Expression analyses showed that AtRNL is expressed throughout zygotic embryogenesis, and in meristematic tissues. Using pAtRNL::cAtRNL‐sYFP‐complemented zyg3/zyg3 plants, we showed that AtRNL is localized exclusively in the cytoplasm, suggesting that tRNA splicing occurs primarily in the cytoplasm. Analyses using partially rescued embryos showed that mutation in AtRNL compromised splicing of intron‐containing tRNA. Mutations of two tRNA endonuclease genes, SEN1 and SEN2, also led to a zygote‐lethal phenotype. These results together suggest that tRNA splicing is critical for initiating zygote division in Arabidopsis.
Vascular endothelial growth factor is neuroprotective against ischemic brain injury by inhibiting scavenger receptor A expression on microglia
Authors: Xu Zheng , Han Kaiwei , Chen Jigang , Wang Chunhui , Dong Yan , Yu Mingkun , Bai Rulin , Huang Chenguang , Hou Lijun 
Published: June 2017

AbstractVascular endothelial growth factor (VEGF) is a secreted mitogen associated with angiogenesis. VEGF has long been thought to be a potent neurotrophic factor for the survival of spinal cord neurons. However, the role of VEGF in the regulation of ischemic brain injury remains unclear. In this study, rats were subjected to MCAO (middle cerebral artery occlusion) followed by intraperitoneal injection of VEGF165 (10 mg/kg) immediately after surgery and once daily until the day 10. The expression of target genes was assayed using qPCR, western blot and immunofluorescence to investigate the role of VEGF165 in regulating ischemic brain injury. We found that VEGF165 significantly inhibited MCAO‐induced up‐regulation of Scavenger receptor class A (SR‐A) on microglia in a VEGFR1‐dependent manner. VEGF165 inhibited lipopolysaccharide (LPS)‐induced expression of proinflammatory cytokines IL‐1β, tumor necrosis factor alpha (TNF‐α) and iNOS in microglia. More importantly, the role of VEGF165 in inhibiting neuroinflammation is partially abolished by SR‐A over‐expression. SR‐A further reduced the protective effect of VEGF165 in ischemic brain injury. These data suggest that VEGF165 suppresses neuroinflammation and ischemic brain injury by inhibiting SR‐A expression, thus offering a new target for prevention of ischemic brain injury.image
Pimozide reduces toxic forms of tau in TauC3 mice via 5′ adenosine monophosphate‐activated protein kinase‐mediated autophagy
Authors: Kim Young Doo , Jeong Eun Il , Nah Jihoon , Yoo Seung‐Min , Lee Won Jae , Kim Youbin , Moon Seowon , Hong Se‐Hoon , Jung Yong‐Keun 
Published: June 2017

AbstractIn neurodegenerative diseases like Alzheimer's disease (AD), tau is hyperphosphorylated and forms aggregates and neurofibrillary tangles in affected neurons. Autophagy is critical to clear the aggregates of disease‐associated proteins and is often altered in patients and animal models of AD. Because mechanistic target of rapamycin (mTOR) negatively regulates autophagy and is hyperactive in the brains of patients with AD, mTOR is an attractive therapeutic target for AD. However, pharmacological strategies to increase autophagy by targeting mTOR inhibition cause various side effects. Therefore, autophagy activation mediated by non‐mTOR pathways is a new option for autophagy‐based AD therapy. Here, we report that pimozide activates autophagy to rescue tau pathology in an AD model. Pimozide increased autophagic flux through the activation of the AMPK‐Unc‐51 like autophagy activating kinase 1 (ULK1) axis, but not of mTOR, in neuronal cells, and this function was independent of dopamine D2 receptor inhibition. Pimozide reduced levels of abnormally phosphorylated tau aggregates in neuronal cells. Further, daily intraperitoneal (i.p.) treatment of pimozide led to a recovery from memory deficits of TauC3 mice expressing a caspase‐cleaved form of tau. In the brains of these mice, we found increased phosphorylation of AMPK1 and ULK1, and reduced levels of the soluble oligomers and NP40‐insoluble aggregates of abnormally phosphorylated tau. Together, these results suggest that pimozide rescues memory impairments in TauC3 mice and reduces tau aggregates by increasing autophagic flux through the mTOR‐independent AMPK‐ULK1 axis.
Peritumoral cuffing by T‐cell tumor‐infiltrating lymphocytes distinguishes HPV‐related oropharyngeal squamous cell carcinoma from oral cavity squamous cell carcinoma
Authors: Poropatich Kate , Hernandez David , Fontanarosa Joel , Brown Koshonna , Woloschak Gayle , Paintal Ajit , Raparia Kirtee , Samant Sandeep 
Published: June 2017

BackgroundIt is unclear why human papillomavirus (HPV)‐related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV‐negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV‐positive and HPV‐negative tumors.MethodsHistologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n=21 HPV DNA‐positive, n=19 HPV DNA‐negative). CD3 and CD8 T‐cell immunostaining were performed on whole‐slide sections to quantify tumor‐infiltrating lymphocyte (TIL) density and assess its morphology.ResultsA subset of cases (HPV‐positive) displayed a unique TIL pattern consisting of circumferential peritumoral population T cells, which was absent in the HPV‐negative cases. The presence of peritumoral cuffing was strongly predictive of improved recurrence‐free survival compared to cases that lacked this morphologic pattern of immune infiltrate. Four HPV‐positive cases lacked the pattern, including two cases with disease recurrence.ConclusionsFor the first time, we show an architectural pattern of immune infiltrate in HNSCC is seen exclusively in HPV‐positive patients with improved recurrence‐free survival and suggests an organized host immunological response contributes to disease control.
The most ordinally egalitarian of random voting rules
Authors: Bogomolnaia Anna 
Published: June 2017

AbstractAziz and Stursberg propose an “Egalitarian Simultaneous Reservation” rule (ESR), a generalization of Serial rule, one of the most discussed mechanisms in the random assignment problem, to the more general random social choice domain. This article provides an alternative definition, or characterization, of ESR as the unique most ordinally egalitarian one. Specifically, given a lottery p over alternatives, for each agent i the author considers the total probability share in p of objects from her first k indifference classes. ESR is shown to be the unique one which leximin maximizes the vector of all such shares (calculated for all i, k). Serial rule is known to be characterized by the same property. Thus, the author provides an alternative way to show that ESR, indeed, coincides with Serial rule on the assignment domain. Moreover, since both rules are defined as the unique most ordinally egalitarian ones, the result shows that ESR is “the right way” to think about generalizing Serial rule.
Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate
Authors: O'Shea Joseph P , Nagarsekar Kalpa , Wieber Alena , Witt Vanessa , Herbert Elisabeth , O'Driscoll Caitriona M , Saal Christoph , Lubda Dieter , Griffin Brendan T , Dressman Jennifer B 
Published: June 2017

Abstract

Objectives
Mesoporous silicas (SLC) have demonstrated considerable potential to improve bioavailability of poorly soluble drugs by facilitating rapid dissolution and generating supersaturation. The addition of certain polymers can further enhance the dissolution of these formulations by preventing drug precipitation. This study uses fenofibrate as a model drug to investigate the performance of an SLC-based formulation, delivered with hydroxypropyl methylcellulose acetate succinate (HPMCAS) as a precipitation inhibitor, in pigs. The ability of biorelevant dissolution testing to predict the in vivo performance was also assessed.

Key findings
Fenofibrate-loaded mesoporous silica (FF-SLC), together with HPMCAS, displayed significant improvements in biorelevant dissolution tests relative to a reference formulation consisting of a physical mixture of crystalline fenofibrate with HPMCAS. In vivo assessment in fasted pigs demonstrated bioavailabilities of 86.69 ± 35.37% with combination of FF-SLC and HPMCAS in capsule form and 75.47 ± 14.58% as a suspension, compared to 19.92 ± 9.89% with the reference formulation. A positive correlation was identified between bioavailability and dissolution efficiency.

Conclusions
The substantial improvements in bioavailability of fenofibrate from the SLC-based formulations confirm the ability of this formulation strategy to overcome the dissolution and solubility limitations, further raising the prospects of a future commercially available SLC-based formulation.
Fabrication of β-cyclodextrin-mediated single bimolecular inclusion complex: characterization, molecular docking, in-vitro release and bioavailability studies for gefitinib and simvastatin conjugate
Authors: Basak Souvik , Mondal Sandip , Dey Suddhasattya , Bhattacharya Plaban , Saha Achintya , Deep Punetha Vinay , Abbas Ali , Gopal Sahoo Nanda 
Published: June 2017

Abstract

Objectives
Introduction of multiple molecules in a single inclusion complex, albeit cheaper, lacks conclusive attempts in earlier drug delivery reports. This manuscript emphasizes simultaneous incorporation of two anticancer drugs, gefitinib (G) and simvastatin (S), in a single molecule of β-cyclodextrin for the first time to achieve effective drug delivery.

Methods
The inclusion complex (GSBCD) was prepared by cosolvent evaporation technique using β-cyclodextrin (BCD) as carrier. Characterization of GSBDC was performed by Fourier transform infrared spectroscopy, COSY, differential scanning calorimetry, X-ray diffraction and dynamic light scattering analyses, which were ascribed to the complex formation inside BCD cavity, micronization of drugs and conversion to amorphous state.

Key findings
The complex revealed entrapment of G and S in 3 ± 0.48: 2 ± 0.19 molar ratio and showed more than 3.5 and 10 fold increase in drug release in in vitro and in vivo, respectively. Docking and COSY studies revealed molecular alignment into BCD central cavity that been achieved via hydrogen bonding between certain groups of the ligands (G and S) and the polar heads of BCD. Partial incorporation of the molecular backbone inside inclusion complex suggests superficial contact with the solvent indicating slow steady release kinetics.

Conclusions
This approach of forming inclusion complex with multiple molecules within a single cavity can be a landmark for further studies in drug delivery.