bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing the cGAMP‐Aluminum Nanoparticles as a Vaccine Adjuvant‐Delivery System (VADS) for Developing the Efficient Pulmonary COVID‐19 Subunit Vaccines
Authors: Wang Ning , Wang Can , Wei Chunliu , Chen Minnan , Gao Yuhao , Zhang Yuxi , Wang Ting 
Published: September 2024

AbstractThe cGAMP‐aluminum nanoparticles (CAN) are engineered as a vaccine adjuvant‐delivery system to carry mixed RBD (receptor‐binding domain) of the original severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its new variant for developing bivalent pulmonary coronavirus disease 2019 (COVID‐19) vaccines (biRBD‐CAN). High phosphophilicity/adsorptivity made intrapulmonary CAN instantly form the pulmonary ingredient‐coated CAN (piCAN) to possess biomimetic features enhancing biocompatibility. In vitro biRBD‐CAN sparked APCs (antigen‐presenting cells) to mature and make extra reactive oxygen species, engendered lysosome escape effects and enhanced proteasome activities. Through activating the intracellular stimulator of interferon genes (STING) and nucleotide‐binding domain and leucine‐rich repeat and pyrin domain containing proteins 3 (NALP3) inflammasome pathways to exert synergy between cGAMP and AN, biRBD‐CAN stimulated APCs to secret cytokines favoring mixed Th1/Th2 immunoresponses. Mice bearing twice intrapulmonary biRBD‐CAN produced high levels of mucosal antibodies, the long‐lasting systemic antibodies, and potent cytotoxic T lymphocytes which efficiently erased cells displaying cognate epitopes. Notably, biRBD‐CAN existed in mouse lungs and different lymph nodes for at least 48 h, unveiling their sustained immunostimulatory activity as the main mechanism underlying the long‐lasting immunity and memory. Hamsters bearing twice intrapulmonary biRBD‐CAN developed high resistance to pseudoviral challenges performed using different recombinant strains including the ones with distinct SARS‐CoV‐2‐spike mutations. Thus, biRBD‐CAN as a broad‐spectrum pulmonary COVID‐19 vaccine candidate may provide a tool for controlling the emerging SARS‐CoV‐2 variants.
A Study on Overcoming Post‐TACE Drug Resistance in HCC Based on Controllable Oxygen Release‐Magnetic Hyperthermia Therapy
Authors: Huang Jin‐Xin , Zhang Wei‐Hua , Wu Ye‐Ming , Hu Jian‐Yu , Long Huan , Zhu Hai‐Dong , Zhang Jian‐Qiong , Teng Gao‐Jun , Xiong Fei 
Published: September 2024

AbstractDrug‐eluting bead transcatheter arterial chemoembolization (D‐TACE) is one of the first‐line treatment for intermediate hepatocellular carcinoma (HCC). However, the dual hypoxia microenvironment, due to inherent tumor hypoxia and TACE‐induced hypoxia, triggers drug resistance in HCC. To address this challenge, the study develops multicavitary microspheres capable of encapsulating oxygen and harnessing magnetic hyperthermia to enhance oxygen permeability. The novel multicavitary oxygen‐encapsulated magnetothermal drug‐eluting microspheres (OTD‐Ms) effectively reduce hypoxia‐related proteins (HIF‐1α, VEGF‐A) and drug resistance (P‐gp) both in vitro and in vivo. Moreover, these microspheres demonstrate improved TACE efficacy and enhance survival rates in a rabbit VX‐2 tumor model, suggesting their potential for HCC treatment.
Twist‐Controlled Ferroelectricity and Emergent Multiferroicity in WSe2 Bilayers
Authors: Hassan Yasir , Singh Budhi , Joe Minwoong , Son Byoung‐Min , Ngo Tien Dat , Jang Younggeun , Sett Shaili , Singha Arup , Biswas Rabindra , Bhakar Monika , Watanabe Kenji , Taniguchi Takashi , Raghunathan Varun , Sheet Goutam , Lee Zonghoon , Yoo Won Jong , Srivastava Pawan Kumar , Lee Changgu 
Published: September 2024

AbstractRecently, researchers have been investigating artificial ferroelectricity, which arises when inversion symmetry is broken in certain R‐stacked, i.e., zero‐degree twisted, van der Waals (vdW) bilayers. Here, the study reports the twist‐controlled ferroelectricity in tungsten diselenide (WSe2) bilayers. The findings show noticeable room temperature ferroelectricity that decreases with twist angle within the range 0° < θ < 3°, and disappears completely for θ ≥ 4°. This variation aligns with moiré length scale‐controlled ferroelectric dynamics (0° < θ < 3°), while loss beyond 4° may relate to twist‐controlled commensurate to non‐commensurate transitions. This twist‐controlled ferroelectricity serves as a spectroscopic tool for detecting transitions between commensurate and incommensurate moiré patterns. At 5.5 K, 3° twisted WSe2 exhibits ferroelectric and correlation‐driven ferromagnetic ordering, indicating twist‐controlled multiferroic behavior. The study offers insights into twist‐controlled coexisting ferro‐ordering and serves as valuable spectroscopic tools.
GraphBNC: Machine Learning‐Aided Prediction of Interactions Between Metal Nanoclusters and Blood Proteins
Authors: Pihlajamäki Antti , Matus María Francisca , Malola Sami , Häkkinen Hannu 
Published: September 2024

AbstractHybrid nanostructures between biomolecules and inorganic nanomaterials constitute a largely unexplored field of research, with the potential for novel applications in bioimaging, biosensing, and nanomedicine. Developing such applications relies critically on understanding the dynamical properties of the nano–bio interface. This work introduces and validates a strategy to predict atom‐scale interactions between water‐soluble gold nanoclusters (AuNCs) and a set of blood proteins (albumin, apolipoprotein, immunoglobulin, and fibrinogen). Graph theory and neural networks are utilized to predict the strengths of interactions in AuNC–protein complexes on a coarse‐grained level, which are then optimized in Monte Carlo‐based structure search and refined to atomic‐scale structures. The training data is based on extensive molecular dynamics (MD) simulations of AuNC–protein complexes, and the validating MD simulations show the robustness of the predictions. This strategy can be generalized to any complexes of inorganic nanostructures and biomolecules provided that one generates enough data about the interactions, and the bioactive parts of the nanostructure can be coarse‐grained rationally.
Graphene Decorated With Mo3S7 Clusters for Sensing CO2
Authors: Casanova‐Chafer Juan , Llobet Eduard , Feliz Marta 
Published: September 2024

AbstractThis paper reports for the first time a gas‐sensitive nanohybrid based on trinuclear molybdenum sulfido clusters ((Bu4N)2[Mo3(μ3‐S)(μ‐S2)3Cl6] (Mo3S7)) supported on graphene flakes (Mo3S7@Graphene). The nanomaterial, once implemented in a chemoresistive device, changes its electrical resistivity when exposed, at room temperature (RT), to toxic and harmful gases, such as hydrogen (H2), carbon dioxide (CO2), carbon monoxide (CO), and benzene. Particularly, the Mo3S7@Graphene hybrid shows an outstanding sensing performance toward CO2. Theoretical calculations provide a better understanding of the plausible gas sensing mechanisms. These findings open the door for a new generation of molybdenum sulfido cluster‐based sensors in which electronic interrogation can be implemented, advancing toward the realization of highly sensitive gas sensing.
N‐Type Molecular Thermoelectrics Based on Solution‐Doped Indenofluorene‐Dimalononitrile: Simultaneous Enhancement of Doping Level and Molecular Order
Authors: Wang Suhao , Wei Huan , Rillaerts Antoine , Deneme İbrahim , Depriester Michael , Manikandan Suraj , Andreasen Jens Wenzel , Daoudi Abdelylah , Peralta Sébastien , Longuemart Stéphane , Usta Hakan , Cornil Jérôme , Hu Yuanyuan , Pisula Wojciech 
Published: September 2024

AbstractThe development of n‐type organic thermoelectric materials, especially π‐conjugated small molecules, lags far behind their p‐type counterparts, due primarily to the scarcity of efficient electron‐transporting molecules and the typically low electron affinities of n‐type conjugated molecules that leads to inefficient n‐doping. Herein, the n‐doping of two functionalized (carbonyl vs dicyanovinylene) indenofluorene‐based conjugated small molecules, 2,8‐bis(5‐(2‐octyldodecyl)thien‐2‐yl)indeno[1,2‐b]fluorene‐6,12‐dione (TIFDKT) and 2,2′‐(2,8‐bis(3‐alkylthiophen‐2‐yl)indeno[1,2‐b]fluorene‐6,12‐diylidene)dimalononitrile (TIFDMT) are demonstrated, with n‐type dopant N‐DMBI. While TIFDKT shows decent miscibility with N‐DMBI, it can be hardly n‐doped owing to its insufficiently low LUMO. On the other hand, TIFDMT, despite a poorer miscibility with N‐DMBI, can be efficiently n‐doped, reaching a respectable electrical conductivity of 0.16 S cm−1. Electron paramagnetic resonance measurements confirm the efficient n‐doping of TIFDMT. Based on density functional theory (DFT) calculations, the LUMO frontier orbital energy of TIFDMT is much lower, and its wave function is more delocalized compared to TIFDKT. Additionally, the polarons are more delocalized in the n‐doped TIFDMT. Remarkably, as indicated by the grazing‐incidence wide‐angle X‐ray scattering (GIWAXS), the molecular order for TIFDMT thin‐film is enhanced by n‐doping, leading to more favorable packing with edge‐on orientation and shorter π‐π stacking distances (from 3.61 to 3.36 Å). This induces more efficient charge transport in the doped state. Upon optimization, a decent thermoelectric power factor of 0.25 µWm−1K−2 is achieved for n‐doped TIFDMT. This work reveals the effect of carbonyl vs dicyanovinylene on the n‐doping efficiency, microstructure evolution upon doping and thermoelectric performance, offering a stepping stone for the future design of efficient n‐type thermoelectric molecules.
Synthesis of Rutaecarpine Analogues by Borrowing Hydrogen Strategy
Authors: Wang Liangfeng , Zhang Linfeng , Zhou Chao , Gou Tiantian , Chen Nan‐Ying , Feng Ke , Li Shiqing , Su Jun‐Cheng , Yu Jingxian , Wang Guixia , Kong Xiangfei 
Published: September 2024

AbstractA series of rutaecarpine analogues were synthesized in 11–90% yields via an iron (II) phthalocyanine‐catalyzed N‐alkylation reaction of 3‐hydroxyethyl quinazolinone‐linked indole. Mechanistic investigation revealed that the formation of C−N bonds in the cyclization reaction occurs through intramolecular borrowing hydrogen annulation. The crucial intermediates in this process were verified by LC–MS analysis and DFT calculations, further supporting the proposed mechanism. Furthermore, biological evaluation demonstrated that some of the synthesized rutaecarpine analogues exhibited good anti‐inflammatory activity.
Photocatalytic Oxidation of α‐Substituted Amines to Lactams/Amides
Authors: Kumar Manish , Kumar Pawan , Das Utpal 
Published: September 2024

AbstractWe, herein, report a base free, photocatalytic decyanation of α‐aminonitriles. A range of amides and lactams were obtained in 52–95% yields. Control experiments indicate O2 as an amide/lactam oxygen source and the reaction (lactam formation) follows radical pathway via dioxetanimine species. This methodology also applied for α‐ester/aldehyde substituted pyrrolidines in the presence of a base, probably via decarboxylation pathway.
Visible‐Light‐Induced Stereoselective C(sp3)−C(sp3)−H Glycosylation for the Synthesis of C‐Glycoamino Acid Derivatives
Authors: Lv Guanghui , Ruan Pingping , Sun Hui , Zhu Yafei , Wang Mi , Zhang Cuimei , Chen Jian , Guo Li , Wu Yong 
Published: September 2024

AbstractChiral C‐Glycosyl amino acids are prevalent structural motifs found in pharmaceuticals and natural products, making them a significant dimension for exploration in modern pharmaceutical and medicinal chemistry. However, the current synthesis methods for these compounds face numerous environmental and practical challenges, highlighting the critical need to establish more sustainable approaches. Herein, we report a simple and powerful strategy for the stereoselective synthesis of C‐glycoamino acids derivatives. This method features the design and use of (−)/(+)‐camphorsultam as an ideal chiral auxiliary, shielding one prochiral face of the glycine α‐carbon efficiently and imposing a high kinetic barrier for the epimerization of thus‐generated chiral α‐carbon that two configuration products of R and S could be achieved independently. It proceeds under mild conditions, shows broad scope, and allows for the direct stereoselective glycosylation without metal and chiral ligand.
Targeting MCH Neuroendocrine Circuit in Lateral Hypothalamus to Protect Against Skeletal Senescence
Authors: Guo Bin , Zhu Yong , Lu Shuai , Chen Xiangming , Ren Zhuoqun , Liu Yuqi , Luo Hao , Wang Chao , Yang Xucheng , Zhu Jianxi 
Published: September 2024

AbstractNeuroendocrine regulation is essential for maintaining metabolic homeostasis. However, whether neuroendocrine pathway influence bone metabolism and skeletal senescence is unelucidated. Here, a central neuroendocrine circuit is identified that directly controls osteogenesis. Using virus based tracing, this study is identified that melanin concentrating hormone (MCH) expressing neurons in the lateral hypothalamus (LH) are connected to the bone. Chemogenetic activation of MCH neurons in the LH induces osteogenesis, whereas inhibiting these neurons reduces osteogenesis. Meanwhile, MCH is released into the circulation upon chemogenetic activation of these neurons. Single cell sequencing reveals that blocking MCH neurons in the LH diminishes osteogenic differentiation of bone marrow stromal cells (BMSCs) and induces senescence. Mechanistically, MCH promotes BMSC differentiation by activating MCHR1 via PKA signaling, and activating MCHR1 by MCH agonists attenuate skeletal senescence in mice. By elucidating a brain‐bone connection that autonomously enhances osteogenesis, these findings uncover the neuroendocrinological mechanisms governing bone mass regulation and protect against skeletal senescence.
Inherent Temporal Metamaterials with Unique Time‐Varying Stiffness and Damping
Authors: Liu Zhiyuan , Yi Kaijun , Sun Haopeng , Zhu Rui , Zhou Xiaoming , Hu Gengkai , Huang Guoliang 
Published: September 2024

AbstractTime‐varying metamaterials offer new degrees of freedom for wave manipulation and enable applications unattainable with conventional materials. In these metamaterials, the pattern of temporal inhomogeneity is crucial for effective wave control. However, existing studies have only demonstrated abrupt changes in properties within a limited range or time modulation following simple patterns. This study presents the design, construction, and characterization of a novel temporal elastic metamaterial with complex time‐varying constitutive parameters induced by self‐reconfigurable virtual resonators (VRs). These VRs, achieved by simulating the resonating behavior of mechanical resonators in digital space, function as virtualized meta‐atoms. The autonomously time‐varying VRs cause significant temporal variations in both the stiffness and loss factor of the metamaterial. By programming the time‐domain behavior of the VRs, the metamaterial's constitutive parameters can be modulated according to desired periodic or aperiodic patterns. The proposed time‐varying metamaterial has demonstrated capabilities in shaping the amplitudes and frequency spectra of waves in the time domain. This work not only facilitates the development of materials with sophisticated time‐varying properties but also opens new avenues for low‐frequency signal processing in future communication systems.
Mitochondrial‐Derived Peptide MOTS‐c Suppresses Ovarian Cancer Progression by Attenuating USP7‐Mediated LARS1 Deubiquitination
Authors: Yin Yadong , Li Yujie , Ma Boyi , Ren Chenlu , Zhao Shuhua , Li Jia , Gong Yun , Yang Hong , Li Jibin 
Published: September 2024

AbstractMitochondrial‐nuclear communication plays a vital role in maintaining cellular homeostasis. MOTS‐c, a short peptide derived from the 12S rRNA of mitochondrial DNA, has been suggested as a retrograde mitochondrial signal. Although recent clinical studies have suggested a possible link between MOTS‐c and human cancer, the role of MOTS‐c in tumorigenesis has yet to be investigated. Here, MOTS‐c levels are found to be reduced in both serum and tumor tissues from ovarian cancer (OC) patients, which are associated with poor patients’ prognosis. Exogenous MOTS‐c inhibits the proliferation, migration and invasion of OC cells, and induces cell cycle arrest and apoptosis. Mechanistically, MOTS‐c interacts with LARS1 and promotes its ubiquitination and proteasomal degradation. In addition, USP7 was identified as a deubiquitinase of LARS1, and MOTS‐c can attenuates USP7‐mediated LARS1 deubiquitination by competing with USP7 for binding to LARS1. Besides, LARS1 was found to be increased and play an important oncogenic function in OC. More importantly, MOTS‐c displays a marked anti‐tumor effect on OC growth without systemic toxicity in vivo. In conclusion, this study reveals a crucial role of MOTS‐c in OC and provides a possibility for MOTS‐c as a therapeutic target for the treatment of this manlignacy.
An Injection Molded SlipChip with Self‐Sampling for Integrated Point‐of‐Care Testing of Human Papilloma Virus
Authors: Zhang Jiajie , Dong Zhangli , Xu Lei , Han Xu , Sheng Zheyi , Chen Weiyu , Zheng Jiayi , Lai Dongmei , Shen Feng 
Published: September 2024

AbstractHigh‐risk human papillomavirus (HPV) screening is crucial for cervical cancer prevention. However, laboratory‐based nucleic acid amplification tests (NAATs) require costly equipment, designated lab space, and skilled personnel. Additionally, cervical swabs collected by healthcare professionals can be inconvenient, uncomfortable, and reduce privacy, limiting broader application and patient compliance. A SlipChip‐based Integrated Point‐of‐Care (SIPOC) system featuring an injection‐molded SlipChip is presented with preloaded reagents for nucleic acid extraction and a portable four‐channel real‐time quantitative PCR instrument for detection. This system incorporates a self‐sampling method that allows participants to collect their own vaginal swabs, with the β‐Globin gene as a control. After testing 130 participants for HPV‐16 and HPV‐18, 97.7% of the self‐collected samples are valid. Among valid samples, 25 tested positive for HPV‐16 and 9 for HPV‐18. Compared to Roche's standard HPV PCR test, the SIPOC system shows 100% positive predictive value (PPV) for both HPV‐16 and HPV‐18 and negative predictive values (NPVs) of 99.0% and 99.1%, respectively. This system is promising for HPV screening in resource‐limited settings and adaptable for other point‐of‐care NAAT applications, including home testing.
Solar‐Driven Evaporator With “Starburst Turbine” Design Featuring Directional Salt Crystallization, Antibacterial, and Catalytic Multifunctionality for Efficient Water Purification
Authors: Yu Jiahui , Li Lele , Liu Yuxuan , Wen Jie , Liu Shu , Li Jiye , Ning Junyi , Shao Changxiang , Wu Tao , Liu Bing 
Published: September 2024

AbstractFacing the global challenge of water scarcity, solar‐driven desalination is considered a sustainable technology for obtaining freshwater from seawater. However, issues such as uncontrolled salt crystallization and bacterial contamination limit its efficiency and practicality. This study proposes an innovative solar‐driven evaporator designed to address these challenges using optimized shape design and advanced photothermal materials. Based on finite element analyses, cylindrical evaporators with a “Starburst Turbine” shape are designed and fabricated, achieving directional salt crystallization and a record‐breaking water collection rate of 3.56 kg m−2 h−1 and an evaporation rate of 4.57 kg m−2 h−1 under one sun illumination. During continuous 60‐h illumination tests, the evaporator maintained a stable evaporation rate, attributed to its excellent directional salt crystallization capability. Additionally, the evaporator demonstrates superior photodynamic antibacterial performance and photocatalytic degradation of organic pollutants. Under one sun illumination for 1 h, it achieves 100% sterilization of S. aureus and E. coli, and a 95.4% degradation of methylene blue (MB), demonstrating its potential to purify various wastewater types. These findings underscore the significant scientific and practical value of integrating antibacterial and photocatalytic functions into solar water purification materials, providing a sustainable solution to global water scarcity challenges and environmental protection.
Enhanced Photocatalytic Hydrogen Evolution Activity Driven by the Synergy Between Surface Vacancies and Cocatalysts: Surface Reaction Matters
Authors: Yue Wenhui , Ye Ziwei , Liu Cong , Xu Zehong , Wang Lingzhi , Cao Xiaoming , Yamashita Hiromi , Zhang Jinlong 
Published: September 2024

AbstractThe incorporation of defects and cocatalysts is known to be effective in improving photocatalytic activity, yet their coupled contribution to the photocatalytic hydrogen evolution process has not been well‐explored. In this study, We demonstrate that the incorporation of S vacancies and NiSe can contribute to the improvement of charge separation efficiency via the formation of a strong electric field within the bulk ZnIn2S4 (ZIS) and on its surface. More importantly, We also demonstrate that the synergy of S vacancies and NiSe benefits the overall hydrogen evolution activity by facilitating the H2O adsorption and dissociation process. This is particularly important for hydrogen evolution taking place under alkaline conditions where the proton concentration is low, allowing ZISv‐NiSe (containing abundant S vacancies) to outperform ZIS‐NiSe under alkaline conditions. In contrast, under acid conditions, since there are already sufficient amounts of protons available for reaction, the hydrogen evolution activity became governed by the hydrogen adsorption/desorption process rather than the H2O dissociation process. This leads to ZIS‐NiSe exhibiting higher activity than ZISv‐NiSe due to its more favorable hydrogen adsorption energy. The findings thus provide insights into how defect and cocatalyst modification strategies can be tailor‐made to improve hydrogen evolution activity under different pH conditions.
Biomimetic Contact Behavior Inspired Tactile Sensing Array with Programmable Microdomes Pattern by Scalable and Consistent Fabrication
Authors: Chen Xiaoliang , Luo Yizhuo , Chen Yun , Li Sheng , Deng Shizheng , Wang Bin , Zhang Qi , Li Xiangmeng , Li Xiangming , Wang Chunhui , He Juan , Tian Hongmiao , Shao Jinyou 
Published: September 2024

AbstractFlexible sensor arrays have attracted extensive attention in human‐computer interaction. However, realizing high‐performance sensor units with programmable properties, and expanding them to multi‐pixel flexible arrays to maintain high sensing consistency is still struggling. Inspired by the contact behavior of octopus antenna, this paper proposes a programmable multistage dome structure‐based flexible sensing array with robust sensing stability and high array consistency. The biomimetic multistage dome structure is pressurized to gradually contact the electrode to achieve high sensitivity and a large pressure range. By adjusting the arrangement of the multistage dome structure, the pressure range and sensitivity can be customized. More importantly, this biomimetic structure can be expanded to a multi‐pixel sensor array at the wafer level with high consistency through scalable and high‐precision imprinting technologies. In the imprinting process, the conductive layer is conformally embedded into the multistage dome structure to improve the stability (maintain stability over 22 000 cycles). In addition, the braced isolation structure is designed to effectively improve the anti‐crosstalk performance of the sensor array (crosstalk coefficient: 26.62 dB). Benefitting from the programmable structural design and high‐precision manufacturing process, the sensor array can be customized and is demonstrated to detect human musculation in medical rehabilitation applications.