bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Model SDLC Dalam Perancangan Sistem Informasi Manajemen Perpustakaan Berbasis Web
Authors: Widianto Fajar 
Published: October 2024

Perpustakaan sekolah sebagai salah satu sarana pendidikan penunjang kegiatan belajar mempunyai peranan penting dalam menunjang tercapainya tujuan pendidikan. Di era milenial merupakan Pengetahuan tidak hanya diperoleh dengan pengalaman secara instan yang membuat manusia memperoleh secara akurat, adakalanya Informasi dapat dilakukan dengan berbagai media, salah satunya dengan media buku yang terdapat di perpustakaan. Perpustakaan merupakan salah satu unsur terpenting dalam dunia pendidikan sebagai bahan referensi dalam proses pembelajaran. Penelitian ini bertujuan untuk membantu dalam pelayanan transaksi pelayanan kebutuhan informasi terhadap kesediaan buku, transaksi peminjaman, transaksi pengembalian dalam sebuah laporan. Sistem Informasi Perpustakaan ini berbasis Website dalam pembuatannya agar lebih efektif sehingga dapat terkoodinir dengan baik dalam pengoptimalan waktu, dengan menerapkan Model SDLC atau Software Development Life Cycle dapat menganalisa kebutuhan sistem sekolah secara detail dan teraplikasi dengan baik sesuai kebutuhan perusahaan. SDLC merupakan salah satu metode yang dimana menghasilkan spesifikasi kebutuhan sistem perangkat lunak. Metode Waterfall menyediakan pendekatan alur hidup perangkat lunak secara sekuensial atau terurut dimulai dari analisis, desain, pengkodean, pengujian system dan kemudian diuji dengan BlackBox testing dilakukan dengan mengamati hasil eksekusi melalui data uji yang menunjukan fungsi-fungsi sistem apakah mampu menyimpan data dalam database dan menampilkan dalam bentuk laporan. Pengujian Black Box juga bertumpu pada memastikan tiap proses sudah berfungsi sesuai dengan kebutuhan yang diharapkan untuk melakukan setiap transaksi.
EFEKTIVITAS TERAPI RELAKSASI OTOT PROGRESIF TERHADAP TEKANAN DARAH PADA LANSIA HIPERTENSI
Authors: Pantouw Angreany , Rondonuwu Peeki , Adam Anggela 
Published: October 2024

Hipertensi merupakan salah satu masalah kesehatan dengan prevalensi yang cukup tinggi dan terus meningkat. Salah satu upaya penanganan pada penderita hipertensi yaitu dengan cara terapi relaksasi otot progresif. Terapi ini mudah dilakukan, tidak memiliki efek samping, membuat tubuh menjadi rileks dan pikiran menjadi tenang. Tujuan penelitian ini adalah untuk mengetahui Efektivitas Relaksasi Otot Progresif Terhadap Tekanan Darah pada lansia hipertensi di RSU GMIM Bethesda Tomohon. Jenis penelitian ini adalah penelitian Quasi Eksperimen yaitu One Group Pre-Posttest Design. Sampel dalam penelitian ini adalah lansia hipertensi berjumlah 57 responden dengan teknik total sampling menggunakan kuisioner, data yang diperoleh dianalisa dengan uji Wilcoxon. Hasil yang diperoleh bahwa terapi sebelum dan sesudah terapi relaksasi otot progresif diperoleh dengan nilai hitung signifikan (p) = 0,00 < α = 0,01 dengan Z hitung = -5,604 yang menunjukan ada pengaruh relaksasi otot progresif terhadap tekanan darah pada lansia hipertensi di RSU GMIM Bethesda Tomohon. Terapi relaksasi otot progresif sangat tepat diberikan pada lansia hipertensi karena dapat menjaga tekanan darah agar tetap stabil.
Simulation of Summer Groundnut for Yield and Yield Attributing Traits Using CROPGRO-Peanut Model
Authors: Mote B. M. , Pandey Vyas , Kumar Neeraj 
Published: October 2024

Field experiments were carried out at College farm, B. A. College of Agriculture, Anand Agricultural University, Anand. The DSSAT v 4.6 CROPGRO-Peanut model was used to predict the phenology of groundnut crop under combinations of three sowing dates and four groundnut cultivars. The model was calibrated with a 2015 dataset of growth and phenological parameters for estimating the genetic coefficients of all four cultivar and was validated with a 2016 dataset of the same parameters. Result found that the model was able to reasonably simulate the pod yield, kernel yield and haulm yield with per cent error ranging (± 10.06) between observed and simulated value for all cultivars under different sowing dates Simulations of yield and yield attributing characters using the calibrated model were found to be quite accurate.
Eurasian Winter Storm Activity at the End of the Century: A CMIP5 Multi‐model Ensemble Projection
Authors: Basu Soumik , Zhang Xiangdong , Wang Zhaomin 
Published: December 2017

AbstractExtratropical cyclone activity over Eurasia has exhibited a weakening trend in the recent decade. Extratropical cyclones bring precipitation and hence supply fresh water for winter crops in the mid‐ and high‐latitude regions of Eurasia. Any changes in extratropical cyclone activity over Eurasia in the future may have a critical impact on winter agriculture and the economies of affected communities. However, potential future changes in regional storm activity over Eurasia have not been studied in detail. Therefore, in this study, we investigate anticipated changes in extratropical storm activity by the end of the century through a detailed examination of the historical and future emission scenarios from six different models from CMIP5. A statistical analysis of different parameters of storm activity using a storm identification and tracking algorithm reveals a decrease in the number of storms over mid‐latitude regions. However, intense storms with longer duration are projected over high latitude Eurasia. A further examination of the physical mechanism for these changes reveals that a decrease in the meridional temperature gradient and a weakening of the vertical wind shear over the mid‐latitudes are responsible for these changes in storm activity.
Influence of Rift Superposition on Lithospheric Response to East African Rift System Extension: Lapur Range, Turkana, Kenya
Authors: Boone Samuel C. , Seiler Christian , Kohn Barry P. , Gleadow Andrew J. W. , Foster David A. , Chung Ling 
Published: December 2017

AbstractThe Turkana Depression of northern Kenya lies at the intersection of the NW‐SE trending late Mesozoic‐early Paleogene South Sudan and Anza rifts and the N‐S trending late Paleogene‐Recent East African Rift System (EARS). A low‐temperature thermochronology study in the Lapur Range reveals a complex tectonothermal evolution related to multiple periods of regional and local tectonism. Zircon (U‐Th)/He data from Precambrian basement record rapid Early Cretaceous denudational cooling. Coeval subsidence in the adjacent Anza and South Sudan rifts (Morley, Bosworth, et al., 1999; Schull, 1988) suggests that the northern Turkana region acted as a basement high separating the grabens, as well as an axial source of sediment. Between ~95 and 90 Ma, a period of reheating commenced with burial of Lapur basement beneath ~500 m of Late Cretaceous‐Eocene Lapur Sandstone and ~1.5–3.5 km of latest Eocene‐early Miocene Turkana volcanics. Apatite fission track (AFT) and apatite (U‐Th‐Sm)/He data record a transition to rapid denudational cooling in the mid‐Miocene (~14 Ma) in response to EARS‐related extension in the northern Turkana Basin. Thermal history models indicate that the Lapur Range experienced ~90–100°C of mid‐Miocene to Plio‐Pleistocene cooling, yielding the first Neogene AFT ages reported from Kenya related to EARS exhumation. We attribute the larger magnitude of cooling in the Lapur Range compared to other regions of the EARS to the attenuated crustal thickness and elevated heat flow of the Turkana Depression, crustal properties inherited from earlier Cretaceous‐Paleogene rifting. The resulting low effective elastic thickness of the Turkana lithosphere allowed for increased isostatic footwall uplift in response to EARS extension.
Electrochemically Synthesis of Nickel Cobalt Sulfide for High‐Performance Flexible Asymmetric Supercapacitors
Authors: Zhang Chunyan , Cai Xiaoyi , Qian Yao , Jiang Haifeng , Zhou Lijun , Li Baosheng , Lai Linfei , Shen Zexiang , Huang Wei 
Published: December 2017

AbstractA lightweight, flexible, and highly efficient energy management strategy is highly desirable for flexible electronic devices to meet a rapidly growing demand. Herein, Ni–Co–S nanosheet array is successfully deposited on graphene foam (Ni–Co–S/GF) by a one‐step electrochemical method. The Ni–Co–S/GF composed of Ni–Co–S nanosheet array which is vertically aligned to GF and provides a large interfacial area for redox reactions with optimum interstitials facilitates the ions diffusion. The Ni–Co–S/GF electrodes have high specific capacitance values of 2918 and 2364 F g−1 at current densities of 1 and 20 A g−1, respectively. Using such hierarchical Ni–Co–S/GF as the cathode, a flexible asymmetric supercapacitor (ASC) is further fabricated with polypyrrple(PPy)/GF as the anode. The flexible asymmetric supercapacitors have maximum operation potential window of 1.65 V, and energy densities of 79.3 and 37.7 Wh kg−1 when the power densities are 825.0 and 16100 W kg−1, respectively. It's worth nothing that the ASC cells have robust flexibility with performance well maintained when the devices were bent to different angles from 180° to 15° at a duration of 5 min. The efficient electrochemical deposition method of Ni–Co–S with a preferred orientation of nanosheet arrays is applicable for the flexible energy storage devices.
Development of a microfluidic platform for high‐throughput screening of non‐viral gene delivery vectors
Authors: Giupponi Elisa , Visone Roberta , Occhetta Paola , Colombo Federica , Rasponi Marco , Candiani Gabriele 
Published: December 2017

AbstractThe grail of gene delivery is the development of delivery vectors as effective and non‐cytotoxic as possible. In this regard, there is an urgent need of new tools for the straightforward and quantitative assessment of transfection efficiency and cytotoxicity simultaneously. We herein reported the development and validation of an easy‐to‐use lab‐on‐chip platform to perform cell transfection assays for unbiased, high‐throughput selection of more and more effective gene delivery vectors by using two commercially sourced lipids, Lipofectamine 2000® and FuGene® 6. A single PDMS‐layer platform was endowed with: i) a chaotic serial dilution generator, designed for the automatic generation of a linear lipoplex dilution (from 100% to 0% with 25% steps) independently delivered to; and ii) the downstream culture and transfection module consisting in five units, each composed of 33 serially connected and fluidically connected culture chambers for trapping small populations of ≈10 cells/chamber. In the absence of any transfectant, cells spread and duplicated up to 2 days. Besides, cells were transfected with EGFP‐encoding reporter gene. The very facile visual inspection of the microdevice by means of a microscope and a semi‐automated analytical method allowed pinpointing the best transfection conditions in terms of efficiency, cytotoxicity, cell doubling rates, and morphological changes at once.
Model for pressure drop and flow deflection in the numerical simulation of stents in aneurysms
Authors: Li Sha , Latt Jonas , Chopard Bastien 
Published: December 2017

AbstractThe numerical simulation of flow diverters like stents contributes to the development and improvement of endovascular stenting procedures, leading ultimately to an improved treatment of intracranial aneurysms. Due to the scale difference between the struts of flow diverters and the full artery, it is common to avoid fully resolved simulations at the level of the stent porosity. Instead, the effect of stents on the flow is represented by a heuristic continuum model. However, the commonly used porous media models describe the properties of flow diverters only partially, because they do not explicitly account for the deflection of the flow direction by the stent. We show that this deficiency can be circumvented by adopting the theoretical framework of screen models. The article first reviews existing screen models. It then proposes an explicit formula for the drag and the deflection coefficient, as predicted by each model, for both perpendicular and inclined angles. The results of 2D numerical simulations are used to formulate a generalization of these formulas, to achieve best results in the case of stent modeling. The obtained model is then validated, again through 2D numerical simulation.
To Take or Not to Take With Meals? Unraveling Issues Related to Food Effects Labeling for Oral Antineoplastic Drugs
Authors: Deng Jiexin , Brar Satjit S. , Lesko Lawrence J. 
Published: December 2017

AbstractThere has been controversy regarding whether bioavailability of certain oral oncology drugs should be maximized by taking these medications with food, irrespective of label instructions in the dosing and administration section. To provide insight into this controversy, we conducted an in‐depth analysis for oral antineoplastic drugs approved by the Food and Drug Administration in 2000‐2016 and identified important issues influencing food labeling decisions. Furthermore, a case study involving sonidegib, a drug approved for locally advanced basal cell carcinoma with a significant food effect on exposure, was used to demonstrate the consequences of failure to adhere to food label recommendations using drug‐specific population pharmacokinetic and exposure‐toxicity models. In 2000‐2009, 80% (4 out of 5) of all approved oral antineoplastics with increased bioavailability in the fed state were labeled as “take on empty stomach.” In contrast, we found that in 2010‐2016 there is a greater diversity in food recommendations for drugs with increased bioavailability in the fed state. Currently, many oral oncology drugs are given with food to maximize their bioavailability; however, as seen from our case study of sonidegib, failure to fully adhere to label recommendations to either take with food or not could lead to adverse consequences in terms of safety and efficacy.
Pharmacokinetics of Diclofenac and Hydroxypropyl‐β‐Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD‐Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment
Authors: Hamilton Douglas A. , Ernst Cynthia C. , Kramer William G. , Madden Donna , Lang Eric , Liao Edward , Lacouture Peter G. , Ramaiya Atulkumar , Carr Daniel B. 
Published: December 2017

AbstractGiven their established analgesic properties, nonsteroidal anti‐inflammatory drugs (NSAIDs) represent an important postoperative pain management option. This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepatic impairment on the pharmacokinetics (PK) of diclofenac and hydroxypropyl‐β‐cyclodextrin (HPβCD) following administration of the injectable NSAID HPβCD‐diclofenac; and (2) the PK of HPβCD following administration of HPβCD‐diclofenac and intravenous itraconazole formulated with HPβCD in healthy adults. Diclofenac clearance (CL) and volume of distribution (Vz) tended to increase with decreasing renal function (moderate insufficiency versus mild insufficiency or healthy controls). Regression analysis demonstrated a significant relationship between Vz (but not CL or elimination half‐life, t½) and renal function. HPβCD CL was significantly decreased in subjects with renal insufficiency, with a corresponding increase in t½. There were no significant differences in diclofenac or HPβCD PK in subjects with mild hepatic impairment versus healthy subjects. Exposure to HPβCD in healthy subjects following HPβCD‐diclofenac administration was ∼12% of that with intravenous itraconazole, after adjusting for dosing schedule and predicted accumulation (<5% without adjustment). With respect to PK properties, these results suggest that HPβCD‐diclofenac might be administered to patients with mild or moderate renal insufficiency or mild hepatic impairment without dose adjustment (NCT00805090).
Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation
Authors: Zempoalteca Rene , Porras Mercedes G. , Moreno‐Pérez Suelem , Ramirez‐Funez Gabriela , Aguirre‐Benítez Elsa L. , González del Pliego Margarita , Mariscal‐Tovar Silvia , Mendoza‐Garrido Maria E. , Hoffman Kurt Leroy , Jiménez‐Estrada Ismael , Melo Angel I. 
Published: December 2017

ABSTRACTEarly adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR‐Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR‐Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR‐Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7–14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351–362, 2018
Compartment‐specific dynamics and functions of autophagy in neurons
Authors: Kulkarni Vineet Vinay , Maday Sandra 
Published: December 2017

ABSTRACTAutophagy is a lysosomal degradation pathway that is critical to maintaining neuronal homeostasis and viability. Autophagy sequesters damaged and aged cellular components from the intracellular environment, and shuttles these diverse macromolecules to lysosomes for destruction. This active surveillance of the quality of the cytoplasm and organelles is essential in neurons to sustain their long‐term functionality and viability. Indeed, defective autophagy is linked to neurodevelopmental abnormalities and neurodegeneration in mammals. Here, we review the mechanisms of autophagy in neurons and functional roles for autophagy in neuronal homeostasis. We focus on the compartment‐specific dynamics of autophagy in neurons, and how autophagy might perform non‐canonical functions critical for neurons. We suggest the existence of multiple populations of autophagosomes with compartment‐specific functions important for neural activity and function. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 298–310, 2018
Opposing deer and caterpillar foraging preferences may prevent reductions in songbird prey biomass in historically overbrowsed forests
Authors: Godfrey R. Keating , Yerger Ellen H. , Nuttle Timothy J. 
Published: December 2017

AbstractOverbrowsing by ungulates decimates plant populations and reduces diversity in a variety of ecosystems, but the mechanisms by which changes to plant community composition influence other trophic levels are poorly understood. In addition to removal of avian nesting habitat, browsing is hypothesized to reduce bird density and diversity through reduction of insect prey on browse‐tolerant hosts left behind by deer. In this study, we excluded birds from branches of six tree species to quantify differences in songbird prey removal across trees that vary in deer browse preference. Early in the breeding season, birds preyed on caterpillars at levels proportional to their abundance on each host. Combining these data with tree species composition data from stands exposed to experimentally controlled deer densities over 30 years ago, we tested whether overbrowsing by white‐tailed deer reduces prey biomass long after deer densities are reduced. Our analysis predicts total prey availability in the canopy of regenerating forests is fairly robust to historic exposure to high deer densities, though distribution of prey available from host species changes dramatically. This predicted compensatory effect was unexpected and is driven by high prey abundance on a single host tree species avoided by browsing deer, Prunus serotina. Thus, while we confirm that prey abundance on host trees can act as a reliable predictor for relative prey availability, this study shows that quantifying prey abundance across host trees is essential to understanding how changes in tree species composition interact with ungulate browse preference to determine prey availability for songbirds.
Development of a genotype‐by‐sequencing immunogenetic assay as exemplified by screening for variation in red fox with and without endemic rabies exposure
Authors: Donaldson Michael E. , Rico Yessica , Hueffer Karsten , Rando Halie M. , Kukekova Anna V. , Kyle Christopher J. 
Published: December 2017

AbstractPathogens are recognized as major drivers of local adaptation in wildlife systems. By determining which gene variants are favored in local interactions among populations with and without disease, spatially explicit adaptive responses to pathogens can be elucidated. Much of our current understanding of host responses to disease comes from a small number of genes associated with an immune response. High‐throughput sequencing (HTS) technologies, such as genotype‐by‐sequencing (GBS), facilitate expanded explorations of genomic variation among populations. Hybridization‐based GBS techniques can be leveraged in systems not well characterized for specific variants associated with disease outcome to “capture” specific genes and regulatory regions known to influence expression and disease outcome. We developed a multiplexed, sequence capture assay for red foxes to simultaneously assess ~300‐kbp of genomic sequence from 116 adaptive, intrinsic, and innate immunity genes of predicted adaptive significance and their putative upstream regulatory regions along with 23 neutral microsatellite regions to control for demographic effects. The assay was applied to 45 fox DNA samples from Alaska, where three arctic rabies strains are geographically restricted and endemic to coastal tundra regions, yet absent from the boreal interior. The assay provided 61.5% on‐target enrichment with relatively even sequence coverage across all targeted loci and samples (mean = 50×), which allowed us to elucidate genetic variation across introns, exons, and potential regulatory regions (4,819 SNPs). Challenges remained in accurately describing microsatellite variation using this technique; however, longer‐read HTS technologies should overcome these issues. We used these data to conduct preliminary analyses and detected genetic structure in a subset of red fox immune‐related genes between regions with and without endemic arctic rabies. This assay provides a template to assess immunogenetic variation in wildlife disease systems.