bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐dependent changes of surface properties of polyether ether ketone caused by air plasma treatment
Authors: Rymuszka Diana , Terpiłowski Konrad , Borowski Piotr , Holysz Lucyna 
Published: April 2016

AbstractThe effect of air plasma treatment on wetting and energy properties, surface composition and morphology of polyether ether ketone (PEEK) was investigated. The influence of the storage time on the surface properties of plasma‐treated polymer plate was also examined. The properties were determined by advancing and receding contact angle measurements, Fourier transform infrared spectroscopy supported by theoretical spectrum modelling, X‐ray photoelectron spectroscopy and optical profilometry. Three theoretical approaches were used in the determination of the apparent surface free energy of the untreated and plasma‐treated PEEK samples from the measured contact angles of probe liquids (water, formamide, diiodomethane): the contact angle hysteresis method, the Owens and Wendt approach and the Lifsthitz − van der Waals acid–base approach. It was found that air plasma treatment of PEEK causes significant chemical and morphological changes of the polymer surface, which are reflected in the decrease of contact angles from 83.4° to 11.7° for water after 180 s plasma treatment. This is due to the formation of polar functional groups resulting in the increase of the surface hydrophilicity. After plasma treatment the apolar component of the surface free energy practically does not change, while the polar component increases significantly, especially for plates treated for 180 s, from 0 to 19.6 mJ m−2. In addition, the modified PEEK surface is not stable during storage and it acquires more hydrophobic character. © 2016 Society of Chemical Industry
A national survey of Canadian emergency medicine residents’ comfort with geriatric emergency medicine
Authors: Snider Tristan , Melady Don , Costa Andrew P. 
Published: April 2016

AbstractBackgroundGeriatric patients represent a large and complex subgroup seen in emergency departments (EDs). Competencies in geriatric emergency medicine (EM) training have been established. Our objectives were to examine Canadian postgraduate year (PGY)-5 EM residents’ comfort with the geriatric EM competency domains, assess whether Canadian EM residents become more comfortable through residency, and determine whether geriatric educational exposures are correlated with resident comfort with geriatric EM.MethodsA national, cross-sectional study of PGY-1 and PGY-5 Royal College EM residents was conducted to determine their comfort in geriatric EM clinical competency domains. Residents reported their level of comfort in satisfying each competency domain using a seven-point Likert scale. Residents were also asked about the location of their medical education as well as the type and number of different geriatric exposures that they had received to date.ResultsOf the 141 eligible residents from across Canada, 77% (109) consented to participate. None of the PGY-1 EM residents and 34% (14) of PGY-5 EM residents reported that they were comfortable with all eight geriatric EM competency domains. PGY-5 EM residents were significantly more comfortable than PGY-1 EM residents. Residents reported a highly variable range of geriatric educational exposures obtained during training. No relationship was found between resident-reported comfort and the nature or number of geriatric exposures that they had received.ConclusionCurrent Royal College EM residency training in Canada may not be adequately preparing graduates to be comfortable with defined competencies for the care of older ED patients.
New Radiocarbon Dates from Tel Kabri Support a High Middle Bronze Age Chronology
Authors: Höflmayer Felix , Yasur-Landau Assaf , Cline Eric H , Dee Michael W , Lorentzen Brita , Riehl Simone 
Published: April 2016

AbstractThis article presents new radiocarbon evidence from the Middle Bronze Age palatial site of Tel Kabri (Israel). The final phase of the palace (Phase III) can be dated to Middle Bronze Age II, with an end date around the transition from Middle Bronze II to III or very early in Middle Bronze III. According to our14C data, the end of Tel Kabri Phase III (and thus the transition from Middle Bronze II to III) can be dated to ~1700 BC. This date is about 50–100 yr earlier than traditional chronological models for the Middle Bronze Age propose (~1650 BC according to the traditional chronology or ~1600 BC according to the low chronology).14C data from Tel Kabri thus add additional evidence for a higher Middle Bronze Age chronology for the Levant, consistent with recent14C evidence from Tell el-Dabca (Egypt), Tel Ifshar (Israel), and Tell el-Burak (Lebanon).
Rural Family Backgrounds, Higher Education, and Marriage Negotiations in Northwest China
Authors: OBENDIEK HELENA 
Published: April 2016

AbstractSince the early twentieth century, reforms of the social institution of marriage in China have profoundly curtailed the power of the senior generation to influence the marriage decisions of their offspring. Yet the marriage considerations of graduates from economically deprived rural family backgrounds in China's northwestern Gansu Province reveal a definite impact of feelings of social obligation towards the family as well as of a local understanding of marriage market stratification which (also) reflects these obligations. In this rural region, higher education mainly aims at long-term upward mobility into the formal urban sector of the economy. After all, the basic ‘citizenship divide’ between rural and urban residence rights established by the socialisthukou(household registration) system continues to determine rural families’ structural exclusion from access to various urban resources. Feelings of indebtedness for financial and other support received from parents and family members during years of higher education entangle graduates from economically deprived rural family backgrounds in webs of social relations that oblige them to also consider the interests of others when deciding on whom to marry. When choosing a marriage partner they thus often face dilemmas of negotiating material versus emotional interests, as well as collective versus individual ones. While higher education empowers them to reject others’ interference in their marriage decisions, if they do so, they have to cope with feelings of having disappointed all the hopes their supporters invested in them.
Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity
Authors: Wolf E. J. , Bovin M. J. , Green J. D. , Mitchell K. S. , Stoop T. B. , Barretto K. M. , Jackson C. E. , Lee L. O. , Fang S. C. , Trachtenberg F. , Rosen R. C. , Keane T. M. , Marx B. P. 
Published: April 2016

BackgroundPost-traumatic stress disorder (PTSD) is associated with elevated risk for metabolic syndrome (MetS). However, the direction of this association is not yet established, as most prior studies employed cross-sectional designs. The primary goal of this study was to evaluate bidirectional associations between PTSD and MetS using a longitudinal design.MethodA total of 1355 male and female veterans of the conflicts in Iraq and Afghanistan underwent PTSD diagnostic assessments and their biometric profiles pertaining to MetS were extracted from the electronic medical record at two time points (spanning ~2.5 years,n= 971 at time 2).ResultsThe prevalence of MetS among veterans with PTSD was just under 40% at both time points and was significantly greater than that for veterans without PTSD; the prevalence of MetS among those with PTSD was also elevated relative to age-matched population estimates. Cross-lagged panel models revealed that PTSD severity predicted subsequent increases in MetS severity (β= 0.08,p= 0.002), after controlling for initial MetS severity, but MetS did not predict later PTSD symptoms. Logistic regression results suggested that for every 10 PTSD symptoms endorsed at time 1, the odds of a subsequent MetS diagnosis increased by 56%.ConclusionsResults highlight the substantial cardiometabolic concerns of young veterans with PTSD and raise the possibility that PTSD may predispose individuals to accelerated aging, in part, manifested clinically as MetS. This demonstrates the need to identify those with PTSD at greatest risk for MetS and to develop interventions that improve both conditions.
Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women
Authors: Shen Minxue , Chaudhry Shazia Hira , MacFarlane Amanda J , Gaudet Laura , Smith Graeme N , Rodger Marc , White Ruth Rennicks , Walker Mark C , Wen Shi Wu 
Published: April 2016

AbstractObjectiveTo examine the association between BMI and folate concentrations in serum and red blood cells (RBC) in pregnant women.DesignA cross-sectional comparison of folate concentrations in serum and RBC sampled simultaneously from the same individual.SettingThe Ottawa Hospital and Kingston General Hospital, Ontario, Canada.SubjectsPregnant women recruited between 12 and 20 weeks of gestation.ResultsA total of 869 pregnant women recruited from April 2008 to April 2009 were included in the final analysis. Serum folate was inversely associated and RBC folate positively associated with BMI, after adjusting for folic acid supplementation, age, gestational age at blood sample collection, race, maternal education, annual income, smoking and MTHFR 677C→T genotype. In stratified analyses, this differential association was significant in women with the MTHFR CC variant. In women with the CT and TT variants, the differential associations were in the same direction but not significant. Folic acid supplementation during pregnancy did not alter the differential association of BMI with serum and RBC folate concentration. This indicates that the current RBC folate cut-off approach for assessing risk of neural tube defects in obese women may be limited.ConclusionsBMI is inversely associated with serum folate and positively associated with RBC folate in pregnant women, especially for those with the MTHFR CC variant.
A survey of prostate cancer patients’ perceptions of the support they receive during radical radiotherapy: is there room for improvement?
Authors: Clarke Hazel , Burke Gemma 
Published: April 2016

AbstractAimThe aim of this study was to ascertain prostate cancer patients’ perceptions of the quality of physical and emotional support they receive as standard during their course of radiotherapy treatment.MethodSemi-structured interviews were conducted on 13 patients undergoing radical radiotherapy treatment for prostate cancer. Interviews were conducted between fractions 32 and 37 and data were analysed using the Giorgi method.ResultsA number of themes emerged from the data including, interestingly, the value of patients’ place on the ‘waiting room support’ with 46% finding this to be a positive aspect of their experience. On the whole, patients felt well supported during their treatment by both radiographers and fellow patients. However, the results highlighted areas for further improvements, particularly around bowel and bladder preparation.ConclusionsThis small single-centre study has highlighted the importance of good quality, timely information provision. Although patients were, for the most part very happy with the services they were being provided with, areas in need of development where also highlighted. If a more structured review process is to be further investigated then the role of the ‘review radiographer’ should be considered as part of this. The potential benefits of patient peer support is also worthy of further exploration.
Prevalence and severity of mental disorders in military personnel: a standardised comparison with civilians
Authors: Trautmann S. , Goodwin L. , Höfler M. , Jacobi F. , Strehle J. , Zimmermann P. , Wittchen H.-U. 
Published: April 2016

Aims.Provision and need for mental health services among military personnel are a major concern across nations. Two recent comparisons suggest higher rates of mental disorders in US and UK military personnel compared with civilians. However, these findings may not apply to other nations. Previous studies have focused on the overall effects of military service rather than the separate effects of military service and deployment. This study compared German military personnel with and without a history of deployment to sociodemographically matched civilians regarding prevalence and severity of 12-month DSM-IV mental disorders.Method.1439 deployed soldiers (DS), 779 never deployed soldiers (NS) and 1023 civilians were assessed with an adapted version of the Munich Composite International Diagnostic interview across the same timeframe. Data were weighted using propensity score methodology to assure comparability of the three samples.Results.Compared with adjusted civilians, the prevalence of any 12-month disorder was lower in NS (OR: 0.7, 95% CI: 0.5–0.99) and did not differ in DS. Significant differences between military personnel and civilians regarding prevalence and severity of individual diagnoses were only apparent for alcohol (DS: OR: 0.3, 95% CI: 0.1–0.6; NS: OR: 0.2, 95% CI: 0.1–0.6) and nicotine dependence (DS: OR: 0.5, 95% CI: 0.3–0.6; NS: OR: 0.5, 95% CI: 0.3–0.7) with lower values in both military samples. Elevated rates of panic/agoraphobia (OR: 2.7, 95% CI: 1.4–5.3) and posttraumatic stress disorder (OR: 3.2, 95% CI: 1.3–8.0) were observed in DS with high combat exposure compared with civilians.Conclusions.Rates and severity of mental disorders in the German military are comparable with civilians for internalising and lower for substance use disorders. A higher risk of some disorders is reduced to DS with high combat exposure. This finding has implications for mental health service provision and the need for targeted interventions. Differences to previous US and UK studies that suggest an overall higher prevalence in military personnel might result from divergent study methods, deployment characteristics, military structures and occupational factors. Some of these factors might yield valuable targets to improve military mental health.
Surprise disrupts cognition via a fronto-basal ganglia suppressive mechanism
Authors: Wessel Jan R. , Jenkinson Ned , Brittain John-Stuart , Voets Sarah H. E. M. , Aziz Tipu Z. , Aron Adam R. 
Published: April 2016

AbstractSurprising events markedly affect behaviour and cognition, yet the underlying mechanism is unclear. Surprise recruits a brain mechanism that globally suppresses motor activity, ostensibly via the subthalamic nucleus (STN) of the basal ganglia. Here, we tested whether this suppressive mechanism extends beyond skeletomotor suppression and also affects cognition (here, verbal working memory, WM). We recorded scalp-EEG (electrophysiology) in healthy participants and STN local field potentials in Parkinson’s patients during a task in which surprise disrupted WM. For scalp-EEG, surprising events engage the same independent neural signal component that indexes action stopping in a stop-signal task. Importantly, the degree of this recruitment mediates surprise-related WM decrements. Intracranially, STN activity is also increased post surprise, especially when WM is interrupted. These results suggest that surprise interrupts cognition via the same fronto-basal ganglia mechanism that interrupts action. This motivates a new neural theory of how cognition is interrupted, and how distraction arises after surprising events.
Magnetic droplet nucleation boundary in orthogonal spin-torque nano-oscillators
Authors: Chung Sunjae , Eklund Anders , Iacocca Ezio , Mohseni Seyed Majid , Sani Sohrab R. , Bookman Lake , Hoefer Mark A. , Dumas Randy K. , Åkerman Johan 
Published: April 2016

AbstractStatic and dynamic magnetic solitons play a critical role in applied nanomagnetism. Magnetic droplets, a type of non-topological dissipative soliton, can be nucleated and sustained in nanocontact spin-torque oscillators with perpendicular magnetic anisotropy free layers. Here, we perform a detailed experimental determination of the full droplet nucleation boundary in the current–field plane for a wide range of nanocontact sizes and demonstrate its excellent agreement with an analytical expression originating from a stability analysis. Our results reconcile recent contradicting reports of the field dependence of the droplet nucleation. Furthermore, our analytical model both highlights the relation between the fixed layer material and the droplet nucleation current magnitude, and provides an accurate method to experimentally determine the spin transfer torque asymmetry of each device.
Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins
Authors: Shen Cuicui , Zhang Delin , Guan Zeyuan , Liu Yexing , Yang Zhao , Yang Yan , Wang Xiang , Wang Qiang , Zhang QunXia , Fan Shilong , Zou Tingting , Yin Ping 
Published: April 2016

AbstractAs a large family of RNA-binding proteins, pentatricopeptide repeat (PPR) proteins mediate multiple aspects of RNA metabolism in eukaryotes. Binding to their target single-stranded RNAs (ssRNAs) in a modular and base-specific fashion, PPR proteins can serve as designable modules for gene manipulation. However, the structural basis for nucleotide-specific recognition by designer PPR (dPPR) proteins remains to be elucidated. Here, we report four crystal structures of dPPR proteins in complex with their respective ssRNA targets. The dPPR repeats are assembled into a right-handed superhelical spiral shell that embraces the ssRNA. Interactions between different PPR codes and RNA bases are observed at the atomic level, revealing the molecular basis for the modular and specific recognition patterns of the RNA bases U, C, A and G. These structures not only provide insights into the functional study of PPR proteins but also open a path towards the potential design of synthetic sequence-specific RNA-binding proteins.
Intermediate honeycomb ordering to trigger oxygen redox chemistry in layered battery electrode
Authors: Mortemard de Boisse Benoit , Liu Guandong , Ma Jiangtao , Nishimura Shin-ichi , Chung Sai-Cheong , Kiuchi Hisao , Harada Yoshihisa , Kikkawa Jun , Kobayashi Yoshio , Okubo Masashi , Yamada Atsuo 
Published: April 2016

AbstractSodium-ion batteries are attractive energy storage media owing to the abundance of sodium, but the low capacities of available cathode materials make them impractical. Sodium-excess metal oxides Na2MO3 (M: transition metal) are appealing cathode materials that may realize large capacities through additional oxygen redox reaction. However, the general strategies for enhancing the capacity of Na2MO3 are poorly established. Here using two polymorphs of Na2RuO3, we demonstrate the critical role of honeycomb-type cation ordering in Na2MO3. Ordered Na2RuO3 with honeycomb-ordered [Na1/3Ru2/3]O2 slabs delivers a capacity of 180 mAh g−1 (1.3-electron reaction), whereas disordered Na2RuO3 only delivers 135 mAh g−1 (1.0-electron reaction). We clarify that the large extra capacity of ordered Na2RuO3 is enabled by a spontaneously ordered intermediate Na1RuO3 phase with ilmenite O1 structure, which induces frontier orbital reorganization to trigger the oxygen redox reaction, unveiling a general requisite for the stable oxygen redox reaction in high-capacity Na2MO3 cathodes.
Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection
Authors: Sódar Barbara W , Kittel Ágnes , Pálóczi Krisztina , Vukman Krisztina V , Osteikoetxea Xabier , Szabó-Taylor Katalin , Németh Andrea , Sperlágh Beáta , Baranyai Tamás , Giricz Zoltán , Wiener Zoltán , Turiák Lilla , Drahos László , Pállinger Éva , Vékey Károly , Ferdinandy Péter , Falus András , Buzás Edit Irén 
Published: April 2016

AbstractCirculating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon in vitro mixing. This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL.
Stellate Cell Networks in the Teleost Pituitary
Authors: Golan Matan , Hollander-Cohen Lian , Levavi-Sivan Berta 
Published: April 2016

AbstractThe folliculostellate cells of the mammalian pituitary are non-endocrine cells that are implicated in long-distance communication and paracrine signaling, but to date, these cells have yet to be characterized in teleosts. We found that the stellate cells of the teleost pituitary share many common attributes with mammalian folliculostellate cells. By labeling of stellate cells in live preparations of tilapia pituitaries we investigated their distribution, association with other endocrine cells and their anatomical and functional coupling. In the pars intermedia, stellate cells were arranged around neuronal bundles and their processes extended into the pars distalis. Within the pars distalis, stellate cells formed close associations with FSH cells and, to a lesser degree, with GH and LH cells, suggesting differential paracrine regulation of the two gonadotrope populations. The production of follistatin by stellate cells further corroborates the notion of a paracrine role on FSH release. We also found stellate cells to form gap junctions that enabled dye transfer to neighboring stellate cells, implicating that these cells form a large-scale network that connects distant parts of the pituitary. Our findings represent the first wide-scale study of stellate cells in teleosts and provide valuable information regarding their functional roles in pituitary function.
Control of complex networks requires both structure and dynamics
Authors: Gates Alexander J. , Rocha Luis M. 
Published: April 2016

AbstractThe study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy state, or a mature cell to a pluripotent state. Two recent methodologies suggest that the controllability of complex systems can be predicted solely from the graph of interactions between variables, without considering their dynamics: structural controllability and minimum dominating sets. We demonstrate that such structure-only methods fail to characterize controllability when dynamics are introduced. We study Boolean network ensembles of network motifs as well as three models of biochemical regulation: the segment polarity network in Drosophila melanogaster, the cell cycle of budding yeast Saccharomyces cerevisiae and the floral organ arrangement in Arabidopsis thaliana. We demonstrate that structure-only methods both undershoot and overshoot the number and which sets of critical variables best control the dynamics of these models, highlighting the importance of the actual system dynamics in determining control. Our analysis further shows that the logic of automata transition functions, namely how canalizing they are, plays an important role in the extent to which structure predicts dynamics.