bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous Lymphadenoma: A Trichoblastoma with Regressive Inflammatory Changes
Authors: Keesecker Sarah , Magro Cynthia , Dokania Vivek , Sclafani Anthony , Saab Jad 
Published: February 2017

AbstractThe authors address the entity of cutaneous lymphadenoma. Although considered benign, cutaneous lymphadenoma can be easily misdiagnosed as basal cell carcinoma because of its close clinical and histological resemblance. This entity is rare and controversial both in terms of its histogenesis and the various diagnostic terms assigned to it throughout the literature. While rare, cutaneous lymphadenoma should be considered in the differential of any facial nodule or papule in addition to the more common basal cell carcinoma, nevi, cysts, and appendiceal tumors.
Local Cutaneous Flaps in Nasal Reconstruction
Authors: Lu Guanning , Kriet J. , Humphrey Clinton 
Published: February 2017

AbstractFacial plastic surgeons use a variety of reconstruction techniques to overcome challenges in restoring the function, structural integrity, and intricate nasal contour in nasal reconstruction. Local cutaneous flaps provide excellent skin texture, thickness, and color match in nasal reconstruction. They offer an excellent cosmetic appearance for small- to medium-sized defects and are preferentially utilized when feasible. This article aims to provide an updated review of local cutaneous flaps for nasal defect repair and describe the major principles related to flap selection.
Mandibular Rim Trilogy with Botulinum Toxin Injection: Reduction, Projection, and Lift
Authors: Zhou Renpeng , Pan Benyun , Wang Chen , Wang Danru 
Published: February 2017

Abstract“Onabotulinum toxin A (Botox) revolution” has brought the fundamental change in the facial rejuvenation as well as the concept of microinjection. The aesthetic standard tends to be the “globalization”; however, Asians have different aesthetic cultures and unique facial features compared with Caucasians. A new rejuvenation concept is proposed during our practice; the Asian face should preserve the original facial identity during Botox treatments. The lower face is treated with botulinum toxin to achieve a harmonious facial profile. Twenty young females ranging in age from 30 to 45 years consented and received the three-pronged procedure from March 2014 to April 2015; photography at baseline and follow-up visit were taken and analyzed. After posttreatment for 2 months, significant improvement was observed compared with the baseline. And the reduced masseter prominence and prominent chin were obtained, showing a favorable facial contour and harmonious appearance during the follow-up. The novel three-pronged approach to lower facial rejuvenation was aimed at the Asian characteristic of hypertrophic masseter, chin retrusion, and the facial sagging during the aging process. Botox treatment was a quite effective and safe strategy to improve the appearance and contour of the lower face in Asian patients.
Social–ecological network analysis of scale mismatches in estuary watershed restoration
Authors: Sayles Jesse S. , Baggio Jacopo A. 
Published: February 2017

SignificanceSpatial misalignments between governance and environmental systems, often called spatial scale mismatch, are a key sustainability challenge. Collaboration and coordination networks can help overcome scale mismatch problems and should align with the environmental system. Using an approach based on network science, this paper advances scale mismatch analysis by explicitly considering collaborations among local and regional organizations doing estuary watershed restoration (i.e., multilevel governance) and how these collaborations align with environmental patterns. Collaboration quality is considered to inform network-based theories for natural resource governance. Integrating network analysis results with ecological habitat data further provides a social–environmental restoration planning perspective. This research can help policymakers allocate resources and is a fundamental step toward addressing scale mismatch while considering multilevel governance.
A network perspective reveals decreasing material diversity in studies on nanoparticle interactions with dissolved organic matter
Authors: Sani-Kast Nicole , Labille Jérôme , Ollivier Patrick , Slomberg Danielle , Hungerbühler Konrad , Scheringer Martin 
Published: February 2017

Significance
Understanding the environmental fate of engineered nanoparticles (ENPs) is essential to the risk assessment of nanotechnology. Dissolved organic matter (DOM) strongly influences the behavior of ENPs in aqueous systems. This influence depends on many factors and, in particular, the types of ENPs and DOM. Accordingly, recent reviews have called repeatedly to expand the range of DOM and ENPs studied. Here, we use a network perspective to assess, in terms of the material types studied, the current state of research into DOM–ENP interactions. We identify global tendencies in the choice of materials and experimental approaches that have contributed to an undesirable discrepancy between the ever-increasing number of published experiments and the persisting call for investigation of more material types.
Seasonal prediction of US summertime ozone using statistical analysis of large scale climate patterns
Authors: Shen Lu , Mickley Loretta J. 
Published: February 2017

Significance
This study identifies the relationship between summertime ozone air quality in the eastern United States and large-scale meteorological patterns, including sea surface temperature (SST) patterns and teleconnections, evolving over the preceding months. We show that this relationship can be used in spring to predict ozone for the following summer. Our work implies that large-scale phenomena such as the Atlantic Multidecadal Oscillation may drive multidecadal variability in US ozone air quality. We find in particular that springtime tropical Atlantic SSTs have a significant influence on summertime meteorology and ozone air quality in the eastern United States, but the free-running, atmosphere-only climate models with prescribed SSTs fail to capture these seasonally evolving teleconnections.
Selenium deficiency risk predicted to increase under future climate change
Authors: Jones Gerrad D. , Droz Boris , Greve Peter , Gottschalk Pia , Poffet Deyan , McGrath Steve P. , Seneviratne Sonia I. , Smith Pete , Winkel Lenny H. E. 
Published: February 2017

SignificanceThe trace element selenium is essential for human health and is required in a narrow dietary concentration range. Insufficient selenium intake has been estimated to affect up to 1 billion people worldwide. Dietary selenium availability is controlled by soil–plant interactions, but the mechanisms governing its broad-scale soil distributions are largely unknown. Using data-mining techniques, we modeled recent (1980–1999) distributions and identified climate–soil interactions as main controlling factors. Furthermore, using moderate climate change projections, we predicted future (2080–2099) soil selenium losses from 58% of modeled areas (mean loss = 8.4%). Predicted losses from croplands were even higher, with 66% of croplands predicted to lose 8.7% selenium. These losses could increase the worldwide prevalence of selenium deficiency.
Sustained disruption of narwhal habitat use and behavior in the presence of Arctic killer whales
Authors: Breed Greg A. , Matthews Cory J. D. , Marcoux Marianne , Higdon Jeff W. , LeBlanc Bernard , Petersen Stephen D. , Orr Jack , Reinhart Natalie R. , Ferguson Steven H. 
Published: February 2017

SignificancePredators are widely understood to impact the structure and stability of ecosystems. In the Arctic, summer sea ice is rapidly declining, degrading habitat for Arctic species, such as polar bears and ringed seals, but also providing more access to important predators, such as killer whales. Using data from concurrently tracked predator (killer whales) and prey (narwhal), we show that the presence of killer whales significantly changes the behavior and distribution of narwhal. Because killer whales are effective predators of many marine mammals, similar predator-induced changes would be expected in the behavior of tracked animals in marine ecosystems worldwide. However, these effects are rarely considered and may frequently go unrecognized.
Designing allostery-inspired response in mechanical networks
Authors: Rocks Jason W. , Pashine Nidhi , Bischofberger Irmgard , Goodrich Carl P. , Liu Andrea J. , Nagel Sidney R. 
Published: February 2017

Significance
We show that removal of a small number of bonds in a random elastic network can dramatically change its mechanical response. Our theoretical approach precisely and efficiently controls the local strain at one point in such a network in response to a strain applied elsewhere in the system. The responses we create are inspired by the long-range-correlated deformations that often characterize allostery in proteins. The ubiquity of allostery in biological molecules suggests that it is relatively easy to develop through evolution. Our nearly 100% success rate in designing these responses by removing a very small fraction of bonds shows that it is similarly easy to create these types of elastic responses in disordered mechanical networks.
Giant ripples on comet 67P/Churyumov–Gerasimenko sculpted by sunset thermal wind
Authors: Jia Pan , Andreotti Bruno , Claudin Philippe 
Published: February 2017

Significance
The recent approach to comet 67P/Churyumov–Gerasimenko by the spacecraft Rosetta has revealed the presence of astonishing dune-like patterns. How can the radial outgassing, caused by heating when passing close to the sun, produce a vapor flow along the surface of the comet dense enough to transport grains? Drawing on the physical mechanisms at work for the formation of dunes on Earth and planetary bodies, we quantitatively explain the emergence and size of these bedforms, which are due to thermal winds. This work involves the understanding of the comet surface processes, especially regarding grain cohesion and grain–fluid interaction. It thus provides more keys to address the timely open question on the growth of planetesimals above the meter scale to form planets.
In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures
Authors: Cain Stuart M. , Bohnet Barry , LeDue Jeffrey , Yung Andrew C. , Garcia Esperanza , Tyson John R. , Alles Sascha R. A. , Han Huili , van den Maagdenberg Arn M. J. M. , Kozlowski Piotr , MacVicar Brian A. , Snutch Terrance P. 
Published: February 2017

Significance
Spreading depression is proposed to underlie migraine with aura, a type of debilitating headache for which few pharmacological treatments are available. The pain drug pregabalin has demonstrated initial promising results for the treatment of migraine in the clinic. Utilizing animal models of congenital migraine and live brain imaging, we describe the cortical and subcortical migration of the spreading depression wave. Further, pregabalin is shown to be effective at suppressing spreading depression initiation, wave speed, and subcortical propagation, and also to affect nerve cell signalling directly. Overall, the study supports the therapeutic potential of pregabalin in both noncongenital migraineurs and patients with mild congenital migraine.
Light-driven growth in Amazon evergreen forests explained by seasonal variations of vertical canopy structure
Authors: Tang Hao , Dubayah Ralph 
Published: February 2017

Significance
Observations of field experiments and satellite imagery have led to a significant debate about light-driven growth of Amazon forests during the dry season. We help resolve these conflicts using observations from spaceborne lidar, and show that both canopy and understory have an opportunistic ecological response to the radiation and moisture regimes. Our research is placed within a consistent ecological framework that links gap theory, field-based studies, and the remote-sensing data record, and which illuminates mechanistic responses of the understory and canopy forming trees to changes in light and water.
Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration
Authors: Hanics János , Szodorai Edit , Tortoriello Giuseppe , Malenczyk Katarzyna , Keimpema Erik , Lubec Gert , Hevesi Zsófia , Lutz Mirjam I. , Kozsurek Márk , Puskár Zita , Tóth Zsuzsanna E. , Wagner Ludwig , Kovács Gábor G. , Hökfelt Tomas G. M. , Harkany Tibor , Alpár Alán 
Published: February 2017

SignificancePersisting proliferative capacity and regeneration in the adult brain are confined to a minority of regions. In the murine brain, the olfactory system is supplied by thousands of newly born neuroblasts daily to support sensory plasticity. Here, we reveal a neuronal scaffold that resides within and alongside this migratory route [termed the “rostral migratory stream” (RMS)] to guide forward migration of newly born neuroblasts. These neurons can externalize the enzyme matrix metalloprotease-2 to loosen the extracellular matrix, thus producing permissive corridors for migrating neuroblasts. This mechanism is likely phylogenetically conserved because it exists in the RMS equivalent in human fetal brains. This inducible mechanism might be pharmacologically targeted for therapeutic benefit.
Effects of Common Angler Handling Techniques on Florida Largemouth Bass Behavior, Feeding, and Survival
Authors: Skaggs Jordan , Quintana Yasmín , Shaw Stephanie L. , Allen Micheal S. , Trippel Nicholas A. , Matthews Michael 
Published: February 2017

Abstract
Black bass Micropterus spp. support popular freshwater sport fisheries in North America. Bass anglers commonly adopt catch and release as a conservation practice, and frequently over 75% of angled black bass are released back into the water. If fish survive the angling event, the practice of catch and release as an alternative to harvest reduces direct mortality, but it has the potential to affect the postrelease feeding behavior and survival of the fish. The act of lifting black bass for handling, hook removal, and photograph opportunities may cause stress and injury, and the degree of injury sustained could be influenced by fish size. Holding fish in a tilted grip by the jaw has raised concern among anglers about potential damage to jaw musculature and tendons, as they may not support the fish's body weight out of water, particularly for trophy bass. We conducted an experiment with Florida Largemouth Bass M. salmoides floridanus to evaluate the relative differences in survival, jaw mechanics, and feeding success after the use of three common handling treatments: (1) a vertical hold using a lip-grip device (vertical treatment); (2) a tilted, one-handed grip using only the lower jaw (horizontal treatment); and (3) two-handed support to the lower jaw and body (support treatment). The time taken by fish to regain equilibrium and resume normal swimming behavior after handling differed among the three treatments; the recovery period was shortest for fish in the support treatment (mean ± SD = 7 ± 10 s; vertical treatment: 33 ± 74 s; horizontal treatment: 12 ± 16 s). Minor injuries (e.g., abrasions and sores) and diseases (e.g., tumors and fungus) tended to increase after handling across the entire sample. Results suggested no evidence of handling-specific differences in fish feeding behavior, jaw adjustments, and mortality after release. However, based on our results, we recommend that anglers use two-handed support to handle Florida Largemouth Bass, thus minimizing the mean amount of time for an individual fish to regain equilibrium after an angling event.
Received February 22, 2016; accepted October 7, 2016 Published online February 22, 2017
Improving mechanical properties of carbon nanotube fibers through simultaneous solid-state cycloaddition and crosslinking
Authors: Lu Xinyi , Hiremath Nitilaksha , Hong Kunlun , Evora Maria C , Ranson Victoria H , Naskar Amit K , Bhat Gajanan S , Kang Nam-Goo , Mays Jimmy W 
Published: February 2017

Abstract
Individual carbon nanotubes (CNTs) exhibit exceptional mechanical properties. However, difficulties remain in fully realizing these properties in CNT macro-assemblies, because the weak inter-tube forces result in the CNTs sliding past one another. Herein, a simple solid-state reaction is presented that enhances the mechanical properties of carbon nanotube fibers (CNTFs) through simultaneous covalent functionalization and crosslinking. This is the first chemical crosslinking proposed without the involvement of a catalyst or byproducts. The specific tensile strength of CNTFs obtained from the treatment employing a benzocyclobutene-based polymer is improved by 40%. Such improvement can be attributed to a reduced number of voids, impregnation of the polymer, and the formation of covalent crosslinks. This methodology is confirmed using both multiwalled nanotube (MWNT) powders and CNTFs. Thermogravimetric analysis, differential scanning calorimetry, x-ray photoelectron spectroscopy, and transmission electron microscopy of the treated MWNT powders confirm the covalent functionalization and formation of inter-tube crosslinks. This simple one-step reaction can be applied to industrial-scale production of high-strength CNTFs.
Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation
Authors: Komai Kyoko , Shichita Takashi , Ito Minako , Kanamori Mitsuhiro , Chikuma Shunsuke , Yoshimura Akihiko 
Published: February 2017

Abstract
Damage-associated molecular patterns (DAMPs) have been implicated in sterile inflammation in various tissue injuries. High-mobility group box 1 (HMGB1) is a representative DAMP, and has been shown to transmit signals through receptors for advanced glycation end products (RAGEs) and TLRs, including TLR2 and TLR4. HMGB1 does not, however, bind to TLRs with high affinity; therefore, the mechanism of HMGB1-mediated TLR activation remains unclear. In this study, we found that fluorescently labeled HMGB1 was efficiently internalized into macrophages through class A scavenger receptors. Although both M1- and M2-type macrophages internalized HMGB1, only M1-type macrophages secreted cytokines in response to HMGB1. The pan-class A scavenger receptor competitive inhibitor, maleylated bovine serum albumin (M-BSA), inhibited HMGB1 internalization and reduced cytokine production from macrophages in response to HMGB1 but not to LPS. The C-terminal acidic domain of HMGB1 is responsible for scavenger receptor-mediated internalization and cytokine production. HMGB1 and TLR4 co-localized in macrophages, and this interaction was disrupted by M-BSA, suggesting that class A scavenger receptors function as co-receptors of HMGB1 for TLR activation. M-BSA ameliorated LPS-induced sepsis and dextran sulfate sodium (DSS)-induced colitis models in which HMGB1 has been shown to play progressive roles. These data suggest that scavenger receptors function as co-receptors along with TLRs for HMGB1 in M1-type inflammatory macrophages.
Catering to Investors Through Security Design: Headline Rate and Complexity*
Authors: Célérier Claire , Vallée Boris 
Published: February 2017

Abstract
This study investigates how banks design financial products to cater to yield-seeking investors. We focus on a large market of investment products targeted exclusively at households: retail structured products. These products typically offer a high return under their best-case scenario—the headline rate—that is nested in a complex payoff formula. Using a text analysis of the payoff formulas of the 55,000 products issued in Europe from 2002 to 2010, we measure product headline rates, complexity, and risk. Over this period, product headline rates depart from the prevailing interest rates as the latter decrease, complexity increases, and risky products become more common. In the cross section, the headline rate of a product is positively correlated with its level of complexity and risk. Higher headline rate, more complex, and riskier products appear more profitable to the banks distributing them. Our results suggest that financial complexity is a by-product of banks catering to yield-seeking investors.
Recognizing age-related macular degeneration in primary care
Authors: Cunningham Jill 
Published: February 2017

ABSTRACT
Age-related macular degeneration (AMD) is a disabling condition that results in central vision loss and significantly affects the quality of life for the growing population of older adults. Primary care providers play a vital role in early recognition of disease. This article reviews the risk factors, symptoms, physical examination findings, and management of AMD. Although there is no cure at this time, early referral and treatment may prevent some patients from progressing to complete vision loss.
Update on asthma and cleaning agents
Authors: Folletti Ilenia , Siracusa Andrea , Paolocci Giulia 
Published: February 2017

Purpose of review
Asthma due to cleaning products has been known for 20 years, and the interest in this topic is still large because of the number of cleaning workers with respiratory problems. In this review, we sought to highlight the most recent findings on the relationship between exposure to cleaning products and asthma and to summarize the specific literature published between 2013 and 2016.

Recent findings
Women are confirmed as most of workers exposed to cleaning products and have a higher frequency than men of work-related respiratory symptoms and diseases. Many cases of asthma due to cleaning products occur in healthcare occupations. The increased risk of asthma has been shown to be related to the number of years in the job and to early life disadvantage. Recent evidence suggests that predisposition to adult-onset asthma may be related to interaction between genes and occupational exposure to low-molecular weight agents/irritants. There is some evidence that an irritant mechanism is more common, although several case reports showed animmunologic mechanism (e.g. disinfectants, amine compounds, aldehydes and fragrances).

Summary
The review updated recent findings on epidemiology, cleaning agents and their mechanism, and prevention of asthma due to cleaning agents. This article provides new information on the level of exposure, which is still high in professional cleaners and even more in domestic cleaners, and on the frequency of asthma in professional and domestic cleaners. An irritant mechanism is more common, although an immunological mechanism is possible, especially in healthcare workers exposed to disinfectants.