bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mouse Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to Autism Spectrum Disorder
Authors: Kogan Jeffrey H. , Gross Adam K. , Featherstone Robert E. , Shin Rick , Chen Qian , Heusner Carrie L. , Adachi Megumi , Lin Amy , Walton Noah M. , Miyoshi Sosuke , Miyake Shinichi , Tajinda Katsunori , Ito Hiroyuki , Siegel Steven J. , Matsumoto Mitsuyuki 
Published: December 2015

The chromosome 15q13.3 microdeletion is a pathogenic copy number variation conferring epilepsy, intellectual disability, schizophrenia, and autism spectrum disorder (ASD). We generated mice carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in human patients. Here, we report that mice with a heterozygous deletion on a C57BL/6 background (D/+ mice) demonstrated phenotypes including enlarged/heavier brains (macrocephaly) with enlarged lateral ventricles, decreased social interactions, increased repetitive grooming behavior, reduced ultrasonic vocalizations, decreased auditory-evoked gamma band EEG, and reduced event-related potentials. D/+ mice had normal body weight, activity levels, sensory gating, and cognitive abilities and no signs of epilepsy/seizures. Our results demonstrate that D/+ mice represent ASD-related phenotypes associated with 15q13.3 microdeletion syndrome. Further investigations using this chromosome-engineered mouse model may uncover the common mechanism(s) underlying ASD and other neurodevelopmental/psychiatric disorders representing the 15q13.3 microdeletion syndrome, including epilepsy, intellectual disability, and schizophrenia.SIGNIFICANCE STATEMENTRecently discovered pathologic copy number variations (CNVs) from patients with neurodevelopmental/psychiatric disorders show very strong penetrance and thus are excellent candidates for mouse models of disease that can mirror the human genetic conditions with high fidelity. A 15q13.3 microdeletion in humans results in a range of neurodevelopmental/psychiatric disorders, including epilepsy, intellectual disability, schizophrenia, and autism spectrum disorder (ASD). The disorders conferred by a 15q13.3 microdeletion also have overlapping genetic architectures and comorbidity in other patient populations such as those with epilepsy and schizophrenia/psychosis, as well as schizophrenia and ASD. We generated mice carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in human patients, which allowed us to investigate the potential causes of neurodevelopmental/psychiatric disorders associated with the CNV.
Curricular Adaptations: Similarities and Differences of their Implementation in Chilean Faculty
Authors: Navarro-Aburto Braulio Ademir , Arriagada Puschel Inés Analía , Osse-Bustingorry Sonia , Burgos-Videla Carmen Gloria 
Published: December 2015

This research describes the process that is performed to carry out curriculum adaptations in the mathematics course for students who showed some type of temporary special education need. The existing coordination between mathematics and special needs’ teachers, as promoter action of the curricular adaptations, has been considered. The methodology used relates to qualitative with a phenomenological approach, and the main data collection technique was the semi-structured interview. In this study, ten teachers of two educational institutions featuring an integration program participated. The main findings show that faculty and responsible staff of the School Integration Program comply with the regulations and requirements of the Decree # 170 in relation to curricular adaptations, but such compliance is subject to informality in the articulation and planning due to lack of time and resources available. Therefore, it is concluded that there is a constant need for curriculum adaptations since these are a mechanism which allows the individualization of education, improving quality of life and special education in Chile
Avaliação de Desempenho de Controllers em Empresas com Sistemas de Remuneração por Recompensa
Authors: Lopes Iago França , Beuren Ilse Maria , Dametto Iara do Rocio Barros 
Published: December 2015

Este estudo objetiva identificar a forma de avaliação de desempenho utilizada para os controllers em empresas que adotam sistemas de remuneração por recompensa. Foi realizada pesquisa descritiva a partir de um levantamento, tendo como população as 58 empresas localizadas na cidade de Curitiba/PR que participaram do Núcleo de Apoio à Gestão da Inovação (NAGI), programa patrocinado pela Financiadora de Estudos e Projetos (FINEP) e pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), executado no Estado do Paraná pelo Serviço Nacional de Aprendizagem Industrial (SENAI). A amostra por acessibilidade compõe-se dos respondentes do questionário e aos dados coletados foi aplicada estatística descritiva. Os resultados da pesquisa evidenciam características da avaliação de desempenho das empresas, composição da remuneração dos controllers e sistemática de remuneração variável dos controllers. Conclui-se que a forma de avaliação de desempenho mais praticada pelas empresas da amostra que adotam sistema de remuneração variável é a participação nos lucros, e que a motivação para a sua implementação sob o ponto de vista dos controllers é indiferente. Esse resultado instiga pesquisas para averiguar em que medida a sistemática de avaliação de desempenho pode contribuir à minimização do conflito de agência, na perspectiva da liberdade dos controllers em termos de subordinação hierárquica.
Crowdsourcing metrics of digital collections
Authors: Pääkkönen Tuula 
Published: December 2015

In the National Library of Finland (NLF) there are millions of digitized newspaper and journal pages, which are openly available via the public website http://digi.kansalliskirjasto.fi. To serve users better, last year the front end was completely overhauled with its main aim in crowdsourcing features, e.g., by giving end-users the opportunity to create digital clippings and a personal scrapbook from the digital collections. But how can you know whether crowdsourcing has had an impact? How much crowdsourcing functionalities have been used so far? Did crowdsourcing work? In this paper the statistics and metrics of a recent crowdsourcing effort are analysed across the different digitized material types (newspapers, journals, ephemera). The subjects, categories and keywords given by the users are analysed to see which topics are the most appealing. Some notable public uses of the crowdsourced article clippings are highlighted. These metrics give us indications on how the end-users, based on their own interests, are investigating and using the digital collections. Therefore, the suggested metrics illustrate the versatility of the information needs of the users, varying from citizen science to research purposes. By analysing the user patterns, we can respond to the new needs of the users by making minor changes to accommodate the most active participants, while still making the service more approachable for those who are trying out the functionalities for the first time. Participation in the clippings and annotations can enrich the materials in unexpected ways and can possibly pave the way for opportunities of using crowdsourcing more also in research contexts. This creates more opportunities for the goals of open science since source data becomes ­available, making it possible for researchers to reach out to the general public for help. In the long term, utilizing, for example, text mining methods can allow these different end-user segments to achieve more. Based on our current initial experiences, we feel that crowdsourcing gives an opportunity for a library context to get closer to the user base and to obtain insight into the numerous opportunities, which the digitized content provides for them and for the library. Gathering the first prototype qualitative and quantitative metrics for this particular crowdsourcing case gives information on how to further improve both the service and the metrics so that they can give valid information for decision-making.
Heading for the Open Road: Costs and Benefits of Transitions in Scholarly Communications
Authors: Jubb Michael 
Published: December 2015

This paper reports on a study — overseen by representatives of the publishing, library and research funder communities in the UK — investigating the drivers, costs and benefits of potential ways to increase access to scholarly journals. It identifies five different but realistic scenarios for moving towards that end over the next five years, including gold and green open access, moves towards national licensing, publisher-led delayed open access, and transactional models. It then compares and evaluates the benefits as well as the costs and risks for the UK. The scenarios, the comparisons between them, and the modelling on which they are based, amount to a benefit-cost analysis to help in appraising policy options over the next five years. Our conclusion is that policymakers who are seeking to promote increases in access should encourage the use of existing subject and institutional repositories, but avoid pushing for reductions in embargo periods, which might put at risk the sustainability of the underlying scholarly publishing system. They should also promote and facilitate a transition to gold open access, while seeking to ensure that the average level of charges for publication does not exceed circa £2,000; that the rate in the UK of open access publication is broadly in step with the rate in the rest of the world; and that total payments to journal publishers from UK universities and their funders do not rise as a consequence.
Twenty Years After: Armenian Research Libraries Today
Authors: Aram Donabedian D. , Carey John , Balayan Arshak 
Published: December 2015

Since achieving statehood in 1991, Armenia has faced major economic and political obstacles which have significantly affected the nation’s research libraries. This research paper will quantitatively and qualitatively examine the challenges facing Armenian research libraries just over twenty years after the collapse of the Soviet Union. Specifically, the authors analyze their interviews with five library administrators at five major institutions, respectively. These include Yerevan State University Library, the National Library of Armenia, the Fundamental Scientific Library of the National Academy of Sciences of Armenia, the Republican Scientific-Medical Library of Armenia, and the Papazian Library of the American University of Armenia. The instrument for the interviews consists of 73 questions based on the 2004 Association of College and Research Libraries Standards for Libraries in Higher Education and evaluates the following factors:
• The library’s mission, goals and objectives
• Public or user services
• Instruction activities at the library
• Resources (print, media, or electronic) and collection development
• Access to the library’s resources
• Outcome assessment, or evaluation of the library
• Staffing issues
• Facility maintenance and plans for library development
• Communication and cooperation both within the library and with the user community
• Administration
• Budget
In addition, we will focus on the strengths and weaknesses of these libraries and investigate the growing open access movement in Armenia. Based on our findings, the authors wish to facilitate dialogue and consider possible approaches to help these libraries meet Armenia’s pressing information needs.
Just in case, just in time, or just don't bother? Assessment of one-shot library instruction with follow-up workshops
Authors: Daland Hilde Terese 
Published: December 2015

This article examines if the timing of library instruction courses is an important part of how students experience library instruction as a means of developing information literacy skills. Two student groups, belonging to different academic subjects, have received the same training and the same assessment questionnaire afterwards. One of the groups was in the middle of writing their student thesis as a part of their final year of their bachelor degree work, the other group consisted of different subjects within the humanities and they were not working specifically with an assignment. Research shows that student’s information seeking skills have not significantly changed over the last some 25 years. One may argue that information literacy skills are so practical that they cannot be taught in a classroom with a theoretical approach. One may also wonder how timing of library instruction affects the learning outcome for students.
Developing data literacy competencies to enhance faculty collaborations
Authors: MacMillan Don 
Published: December 2015

In order to align information literacy instruction with changing faculty and student needs, librarians must expand their skills and competencies beyond traditional information sources. In the sciences, this increasingly means integrating the data resources used by researchers into instruction for undergraduate students. Open access data repositories allow students to work with more primary data than ever before, but only if they know how and where to look. This paper will describe the development of two information literacy workshops designed to scaffold student learning in the biological sciences across two second-year courses, detailing the long-term collaboration between a librarian and an instructor that now serves over 500 students per semester. In each workshop, students are guided through the discovery and analysis of life sciences data from multiple sites, encouraged to integrate text and data sources, and supported in completing research assignments.
On J M Keynes’s Rejection of the Moscow School of Probability’s Limiting Frequency Approach to Probability and Kolmogorov’s Axiom of Additivity (Countable Additivity ): Non –Additivity was the fundamental, basic axiom upon which all of the Economics of Ke
Authors: Brady Michael Emmett 
Published: December 2015

<p>J M Keynes was an acknowledged, world renown, and internationally recognized expert in probability and statistics in the 1930’s based on his A Treatise on Probability (1921). . Keynes had been selected by statistics journals to serve as a referee during the 1930’s. It is, therefore, no surprise that he was selected as the referee by the League of Nations to review Jan Tinbergen’s work on business cycles that used an econometrics approach based on The Law of Large Numbers, the Central Limit Theorem, and the Gaussian (Normal) Distribution .The fundamental axiom used by Tinbergen was additivity . Kolmogorov and the Moscow School of Probability’s main innovation was to go from the axiom of additivity to the axiom of countable additivity. However, Keynes rejected additivity except in the special case that the weight of the evidence, w, which measured the relative completeness of the evidence ,defined on the closed unit interval [0,1],equaled 1 , approached 1,or approximated 1. Keynes also accepted goodness of fit tests, such as the Lexis –Q test, and exploratory data analysis as evidence that could be used to support using a particular probability distribution.</p>
Telehealth Implementation in a Skilled Nursing Facility: Case Report for Physical Therapist Practice in Washington
Authors: Lee Alan Chong W. , Billings Michael 
Published: December 2015

Background and PurposeTelehealth is defined as the delivery of health-related services and information via telecommunication technologies. The purposes of this case report are: (1) to describe the development, implementation, and evaluation of a telehealth approach for meeting physical therapist supervision requirements in a skilled nursing facility (SNF) in Washington and (2) to explore clinical and human factors of physical therapist practice in an SNF delivered via telehealth.Case DescriptionIn 2009, Infinity Rehab conducted a pilot program to determine whether telehealth could be used to meet physical therapist supervision requirements in an SNF. In 2011, language allowing telehealth physical therapy was approved by the Washington Board of Physical Therapy (Board). In 2014–2015, telehealth outcomes were evaluated in a 51-person sample at an Infinity Rehab SNF. Cost savings of telehealth implementation from 2011 to 2015 were estimated.OutcomesThe Board deemed the telehealth pilot program a success and subsequently established telehealth practice language for physical therapy. Both human factors and clinical outcomes were required to implement a successful telehealth practice. Clinical outcomes and user satisfaction in telehealth and nontelehealth groups were equivalent. Cost savings were identified.DiscussionHuman factors, such as the need for provider education in appropriate bedside manner with a telehealth session, were identified. Since 2011, more than 1,000 telehealth physical therapy sessions were conducted at Infinity Rehab SNFs in Washington State. In the future, alternative payment models focused on valued-based clinical outcomes may facilitate wider telehealth adoption in physical therapy. Future research on efficacy and cost-effectiveness is needed to promote broader adoption of telehealth physical therapy in SNFs. This experience demonstrates that telehealth implementation in an SNF for the purpose of physical therapy re-evaluation is a feasible alternative to in-person encounters.
Origin of craniopharyngiomas: implications for growth pattern, clinical characteristics, and outcomes of tumor recurrence
Authors: Bao Yun , Pan Jun , Qi Song-tao , Lu Yun-tao , Peng Jun-xiang 
Published: December 2015

OBJECT
Craniopharyngiomas are associated with a high rate of recurrence. The surgical management of recurrent lesions has been among the most challenging neurosurgical procedures because of the craniopharyngioma's complex topographical relationship with surrounding structures. The aim of this study was to define the determinative role of the site of origin on the growth pattern and clinical features of recurrent craniopharyngiomas.

METHODS
The authors performed a retrospective analysis of 52 patients who had undergone uniform treatment by a single surgeon. For each patient, data concerning symptoms and signs, imaging features, hypothalamic-pituitary function, and recurrence-free survival rate were collected.

RESULTS
For children, delayed puberty was more frequent in the group with Type I (infradiaphragmatic) craniopharyngioma than in the group with Type TS (tuberoinfundibular and suprasellar extraventricular) lesions (p < 0.05). For adults, blindness was more frequent in the Type I group than in the Type TS group (p < 0.05). Nausea or vomiting, delayed puberty, and growth retardation were more frequent in children than in adults (p < 0.05). Overall clinical outcome was good in 48.07% of the patients and poor in 51.92%. Patients with Type TS recurrent tumors had significantly worse functional outcomes and hypothalamic function than patients with the Type I recurrent tumors but better pituitary function especially in children.

CONCLUSIONS
The origin of recurrent craniopharyngiomas significantly affected the symptoms, signs, functional outcomes, and hypothalamic-pituitary functions of patients undergoing repeated surgery. Differences in tumor growth patterns and site of origin should be considered when one is comparing outcomes and survival across treatment paradigms in patients with recurrent craniopharyngiomas.
A cadaveric microanatomical study of the fascicular topography of the brachial plexus
Authors: Sinha Sumit , Prasad G. Lakshmi , Lalwani Sanjeev 
Published: December 2015

OBJECT
Mapping of the fascicular anatomy of the brachial plexus could provide the nerve surgeon with knowledge of fascicular orientation in spinal nerves of the brachial plexus. This knowledge might improve the surgical outcome of nerve grafting in brachial plexus injuries by anastomosing related fascicles and avoiding possible axonal misrouting. The objective of this study was to map the fascicular topography in the spinal nerves of the brachial plexus.

METHODS
The entire right-sided brachial plexus of 25 adult male cadavers was dissected, including all 5 spinal nerves (C5–T1), from approximately 5 mm distal to their exit from the intervertebral foramina, to proximal 1 cm of distal branches. All spinal nerves were tagged on the cranial aspect of their circumference using 10-0 nylon suture for orientation. The fascicular dissection of the C5–T1 spinal nerves was performed under microscopic magnification. The area occupied by different nerve fascicles was then expressed as a percentage of the total cross-sectional area of a spinal nerve.

RESULTS
The localization of fascicular groups was fairly consistent in all spinal nerves. Overall, 4% of the plexus supplies the suprascapular nerve, 31% supplies the medial cord (comprising the ulnar nerve and medial root of the median nerve [MN]), 27.2% supplies the lateral cord (comprising the musculocutaneous nerve and lateral root of the MN), and 37.8% supplies the posterior cord (comprising the axillary and radial nerves).

CONCLUSIONS
The fascicular dissection and definitive anatomical localization of fascicular groups is feasible in plexal spinal nerves. The knowledge of exact fascicular location might be translatable to the operating room and can be used to anastomose related fascicles in brachial plexus surgery, thereby avoiding the possibility of axonal misrouting and improving the results of plexal reconstruction.
Effectiveness of 2-methoxyestradiol in alleviating angiogenesis induced by intracranial venous hypertension
Authors: Zou Xiang , Zhou Liangfu , Zhu Wei , Mao Ying , Chen Liang 
Published: December 2015

OBJECT
Intracranial dural arteriovenous fistulas (DAVFs) are complex intracranial vascular malformations that can lead to hemorrhage. The authors recently found that chronic local hypoperfusion seems to be the main cause of angiogenesis in the dura mater, which leads to the formation of DAVFs. As a natural derivative of estradiol, 2-methoxyestradiol (2-ME) has an antiangiogenic effect and can be used safely in patients with advanced carcinoid tumors. This study was conducted to examine the antiangiogenic effects of 2-ME on a rat DAVF model.

METHODS
Male Sprague-Dawley rats (n = 72) were used in the experiments. Intracranial venous hypertension was induced for modeling, and 2-ME was used in the early or late stage for treatment. The effects were examined by immunohistochemistry, Western blot analysis, and quantitative real-time polymerase chain reaction assays.

RESULTS
2-Methoxyestradiol significantly reduced angiogenesis in the dura in early- and late-intervention treatment groups, as proven by the results of immunohistochemical staining, Western blotting, real-time polymerase chain reaction assays, and microvessel density counts. The antiangiogenic effect even lasted for up to 2 weeks after 2-ME cessation.

CONCLUSIONS
These data collectively suggest that 2-ME can reduce the angiogenic effect caused by venous hypertension in a rat DAVF model, mainly by suppressing the inhibitor of differentiation 1 (ID-1) and hypoxia-inducible factor 1α (HIF-1α) pathways.