bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of Laparoscopic Total Mesorectal Excision with Extended Lateral Pelvic Lymph Node Dissection for Advanced Lower Rectal Cancer after Preoperative Chemoradiotherapy
Authors: Ogura Atsushi , Akiyoshi Takashi , Nagasaki Toshiya , Konishi Tsuyoshi , Fujimoto Yoshiya , Nagayama Satoshi , Fukunaga Yosuke , Ueno Masashi , Kuroyanagi Hiroya 
Published: October 2016

AbstractBackgroundThe feasibility of additional lateral pelvic lymph node dissection (LPLND) compared with total mesorectal excision (TME) alone in patients treated with preoperative chemoradiotherapy (CRT) is controversial, especially in laparoscopic surgery. This study was performed to evaluate the feasibility of adding laparoscopic LPLND to TME in patients with advanced lower rectal cancer and swollen LPLNs treated with preoperative CRT.MethodsWe reviewed 327 patients with lower rectal cancer without distant metastasis who underwent preoperative CRT followed by laparoscopic TME. Laparoscopic LPLND was added in patients with swollen LPLNs before CRT. Outcomes were compared between patients with (n = 107) and without (n = 220) LPLND.ResultsLPLN metastasis was found in 26 patients (24.3 %) in the LPLND group. The operation time was significantly longer, and total blood loss was significantly greater in the LPLND than TME group (461 vs. 298 min and 115 vs. 30 mL, respectively; P < 0.0001). The major complication rate was similar in the LPLND and TME groups (9.3 vs. 5.5 %, respectively; P = 0.188), and there were no conversions to open surgery. The LPLND and TME groups also showed a similar 3‐year relapse‐free survival rate (84.7 vs. 82.0 %, respectively; P = 0.536) and local recurrence rate (3.2 vs. 5.2 %, respectively; P = 0.569) despite significantly more patients with pathological lymph node metastasis in the LPLND than TME group (37.4 vs. 22.3 %, respectively; P < 0.0001).ConclusionsAdditional laparoscopic LPLND is feasible in patients with advanced lower rectal cancer and clinically swollen LPLNs treated with preoperative CRT, with no significant increase in major complications compared with TME alone.
Neonatal interventions differently affect maternal care quality and have sexually dimorphic developmental effects on corticosterone secretion
Authors: de Sá Couto‐Pereira Natividade , Ferreira Charles Francisco , Lampert Carine , Arcego Danusa Mar , Toniazzo Ana Paula , Bernardi Juliana Rombaldi , da Silva Diego Carrilho , Von Poser Toigo Eduardo , Diehl Luisa Amalia , Krolow Rachel , Silveira Patrícia Pelufo , Dalmaz Carla 
Published: October 2016

AbstractNeonatal handling (H) and maternal separation (MS) both induce changes in maternal care, but the contribution of these changes to the behavioral and neurochemical outcomes of the offspring remains unclear, as studies often find opposite results concerning the frequency of maternal behaviors, particularly in the MS paradigm. In this study, behavior displayed by H, MS and non‐handled (NH) Wistar rat dams were observed during the first 10 days after birth. A tentative assessment of the quality of maternal care was made, using a previously reported score that reflects behavior fragmentation and inconsistency. Central oxytocin levels and hippocampal synaptic plasticity markers were also evaluated in dams, immediately after litter weaning. In adulthood, male and female offspring were subjected to a contextual stress‐induced corticosterone challenge to provide further information on the impact of early interventions on neuroendocrine parameters. We found that while both H and MS interventions induced an increase in the amount of pup‐directed behavior, MS dams displayed a more fragmented and inconsistent pattern of care, reflecting poorer maternal care quality. Interestingly, an increase in oxytocin levels was observed only in H dams. While H offspring did not differ from NH, MS males and females showed marked differences in corticosterone secretion compared to controls. Our results suggest that briefly removing the pups from the nest alters maternal care quantity but not quality and increases central oxytocin, while long separations appear to increase low quality maternal care and change neuroendocrine responses in adult offspring in a sex‐specific manner.
Phytolith and diatom evidence for rice exploitation and environmental changes during the early mid-Holocene in the Yangtze Delta
Authors: Zuo Xinxin , Lu Houyuan , Li Zhen , Song Bing , Xu Deke , Zou Yafei , Wang Can , Huan Xiujia , He Keyang 
Published: October 2016

AbstractUsing phytolith analysis from a well-dated and high-resolution sediment sequence in the apex of northern Yangtze Delta, we investigate environmental changes, the rise and decline of rice exploitation and possible impacts of environment on rice exploitation during the early mid-Holocene. The phytolith sequence documents a relatively warm and dry interval during ca.9000 to 8200 cal yr BP, followed by climatic amelioration before 7200 cal yr BP. Phytolith evidence indicates that rice exploitation at the apex of northern Yangtze Delta began at 8200 cal yr BP, flourished by 7700 cal yr BP and ceased after 7400 cal yr BP. The first emergence of marine diatom species approximately 7300 cal yr BP likely indicates an accelerated sea-level rise. The apparent correlation of the initiation of rice exploitation with climatic amelioration during the early mid-Holocene suggests that climatic changes may have played an important role in facilitating rice exploitation. Both the ideal climatic conditions and stable sea level enabled flourishing rice exploitation during 8200 to 7400 cal yr BP. Although the climate remained warm and wet after 7400 cal yr BP, local sea-level rise possibly led to the termination of earlier rice exploitation at this site of the northern Yangtze Delta.
Earliest direct evidence of monument building at the archaeological site of Nan Madol (Pohnpei, Micronesia) identified using 230Th/U coral dating and geochemical sourcing of megalithic architectural stone
Authors: McCoy Mark D. , Alderson Helen A. , Hemi Richard , Cheng Hai , Edwards R. Lawrence 
Published: October 2016

AbstractArchaeologists commonly use the onset of the construction of large burial monuments as a material indicator of a fundamental shift in authority in prehistoric human societies during the Holocene. High-quality direct evidence of this transition is rare. We report new interdisciplinary research at the archaeological site of Nan Madol that allows us to specify where and when people began to construct monumental architecture in the remote islands of the Pacific. Nan Madol is an ancient administrative and mortuary center and the former capital of the island of Pohnpei. It was constructed over 83 ha of lagoon with artificial islets and other architecture built using columnar basalt and coral. We employed geochemical sourcing of basalt used as architectural stone and high-precision uranium-thorium series dates (230Th/U) on coral from the tomb of the first chief of the entire island to identify the beginning of monument building at Nan Madol in AD 1180-1200. Over the next several centuries (AD 1300-1600) monument building began on other islands across Oceania. Future research should be aimed at resolving the causes of these social transformations through higher quality data on monument building.
Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
Authors: Allaoui Roni , Bergenfelz Caroline , Mohlin Sofie , Hagerling Catharina , Salari Kiarash , Werb Zena , Anderson Robin L. , Ethier Stephen P. , Jirström Karin , Påhlman Sven , Bexell Daniel , Tahin Balázs , Johansson Martin E. , Larsson Christer , Leandersson Karin 
Published: October 2016

AbstractTriple-negative (TN) breast cancers (ER−PR−HER2−) are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate in vivo and develop into immunosuppressive myeloid cells expressing the myeloid-derived suppressor cell marker S100A9 only in a TN breast cancer environment. This results in activation of cancer-associated fibroblasts and expression of CXCL16, which we show to be a monocyte chemoattractant. We propose that this migratory feedback loop amplifies the formation of a reactive stroma, contributing to the aggressive phenotype of TN breast tumours. These insights could help select more suitable therapies targeting the stromal component of these tumours, and could aid prediction of drug resistance.
Short-Lived Cages Restrict Protein Diffusion in the Plasma Membrane
Authors: Goiko Maria , de Bruyn John R. , Heit Bryan 
Published: October 2016

AbstractThe plasma membrane is a heterogeneous environment characterized by anomalous diffusion and the presence of microdomains that are molecularly distinct from the bulk membrane. Using single particle tracking of the C-type lectin CD93, we have identified for the first time the transient trapping of transmembrane proteins in cage-like microdomains which restrict protein diffusion. These cages are stabilized by actin-dependent confinement regions, but are separate structures with sizes and lifespans uncorrelated to those of the underlying actin corral. These membrane cages require cholesterol for their strength and stability, with cholesterol depletion decreasing both. Despite this, cages are much larger in size and are longer lived than lipid rafts, suggesting instead that cholesterol-dependent effects on membrane fluidity or molecular packing play a role in cage formation. This diffusional compartment in the plasma membrane has characteristics of both a diffusional barrier and a membrane microdomain, with a size and lifespan intermediate between short-lived microdomains such as lipid rafts and long-lasting diffusional barriers created by the actin cytoskeleton.
Neonatal imitation predicts infant rhesus macaque (Macaca mulatta) social and anxiety-related behaviours at one year
Authors: Kaburu Stefano S. K. , Paukner Annika , Simpson Elizabeth A. , Suomi Stephen J. , Ferrari Pier F. 
Published: October 2016

AbstractThe identification of early markers that predict the development of specific social trajectories is critical to understand the developmental and neurobiological underpinnings of healthy social development. We investigated, in infant rhesus macaques (Macaca mulatta), whether newborns’ capacity to imitate facial gestures is a valid predictive marker for the emergence of social competencies later in development, at one year of age. Here we first assessed whether infant macaques (N = 126) imitate lipsmacking gestures (a macaque affiliative expression) performed by a human experimenter in their first week of life. We then collected data on infants’ social interactions (aggression, grooming, and play) and self-scratching (a proxy indicator of anxiety) at 11–14 months when infants were transferred into a new enclosure with a large social group. Our results show that neonatal imitators exhibit more dominant behaviours, are less anxious, and, for males only, spend more time in play at one year old. These findings suggest that neonatal imitation may be an early predictor of infant sociality and may help identify infants at risk of neurodevelopmental social deficits.
Genetic dissection of host immune response in pneumonia development and progression
Authors: Smelaya Tamara V. , Belopolskaya Olesya B. , Smirnova Svetlana V. , Kuzovlev Artem N. , Moroz Viktor V. , Golubev Arkadiy M. , Pabalan Noel A. , Salnikova Lyubov E. 
Published: October 2016

AbstractThe role of host genetic variation in pneumonia development and outcome is poorly understood. We studied common polymorphisms in the genes of proinflammatory cytokines (IL6 rs1800795, IL8 rs4073, IL1B rs16944), anti-inflammatory cytokines (IL10 rs1800896, IL4 rs2243250, IL13 rs20541) and toll-like receptors (TLR2 rs5743708 and rs4696480, TLR4 rs4986791, TLR9 rs352139, rs5743836 and rs187084) in patients with community-acquired pneumonia (CAP) (390 cases, 203 controls) and nosocomial pneumonia (355 cases, 216 controls). Experimental data were included in a series of 11 meta-analyses and eight subset analyses related to pneumonia susceptibility and outcome. TLR2 rs5743708 minor genotype appeared to be associated with CAP/Legionnaires’ disease/pneumococcal disease. In CAP patients, the IL6 rs1800795-C allele was associated with severe sepsis/septic shock/severe systemic inflammatory response, while the IL10 rs1800896-A allele protected against the development of these critical conditions. To contribute to deciphering of the above results, we performed an in silico analysis and a qualitative synthesis of literature data addressing basal and stimulated genotype-specific expression level. This data together with database information on transcription factors’ affinity changes caused by SNPs in putative promoter regions, the results of linkage disequilibrium analysis along with SNPs functional annotations supported assumptions about the complexity underlying the revealed associations.
Electric Field-aided Selective Activation for Indium-Gallium-Zinc-Oxide Thin Film Transistors
Authors: Lee Heesoo , Chang Ki Soo , Tak Young Jun , Jung Tae Soo , Park Jeong Woo , Kim Won-Gi , Chung Jusung , Jeong Chan Bae , Kim Hyun Jae 
Published: October 2016

AbstractA new technique is proposed for the activation of low temperature amorphous InGaZnO thin film transistor (a-IGZO TFT) backplanes through application of a bias voltage and annealing at 130 °C simultaneously. In this ‘electrical activation’, the effects of annealing under bias are selectively focused in the channel region. Therefore, electrical activation can be an effective method for lower backplane processing temperatures from 280 °C to 130 °C. Devices fabricated with this method exhibit equivalent electrical properties to those of conventionally-fabricated samples. These results are analyzed electrically and thermodynamically using infrared microthermography. Various bias voltages are applied to the gate, source, and drain electrodes while samples are annealed at 130 °C for 1 hour. Without conventional high temperature annealing or electrical activation, current-voltage curves do not show transfer characteristics. However, electrically activated a-IGZO TFTs show superior electrical characteristics, comparable to the reference TFTs annealed at 280 °C for 1 hour. This effect is a result of the lower activation energy, and efficient transfer of electrical and thermal energy to a-IGZO TFTs. With this approach, superior low-temperature a-IGZO TFTs are fabricated successfully.
Mechanisms underlying heterologous skin scaffold-mediated tissue remodeling
Authors: Mimura Kallyne K. O. , Moraes Andréia R. , Miranda Aline C. , Greco Rebecca , Ansari Tahera , Sibbons Paul , Greco Karin V. , Oliani Sonia M. 
Published: October 2016

AbstractBiocompatibility of two newly developed porcine skin scaffolds was assessed after 3, 14, 21 and 90 days of implantation in rats. Both scaffolds showed absence of cells, preservation of ECM and mechanical properties comparable to non-decellularised skin before implantation. Host cell infiltration was much prominent on both scaffolds when compared to Permacol (surgical control). At day 3, the grafts were surrounded by polymorphonuclear cells, which were replaced by a notable number of IL-6-positive cells at day 14. Simultaneously, the number of pro-inflammatory M1-macrophage was enhanced. Interestingly, a predominant pro-remodeling M2 response, with newly formed vessels, myofibroblasts activation and a shift on the type of collagen expression was sequentially delayed (around 21 days). The gene expression of some trophic factors involved in tissue remodeling was congruent with the cellular events. Our findings suggested that the responsiveness of macrophages after non-crosslinked skin scaffolds implantation seemed to intimately affect various cell responses and molecular events; and this range of mutually reinforcing actions was predictive of a positive tissue remodeling that was essential for the long-standing success of the implants. Furthermore, our study indicates that non-crosslinked biologic scaffold implantation is biocompatible to the host tissue and somehow underlying molecular events involved in tissue repair.
Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium
Authors: Horiuchi Y , Kondo M A , Okada K , Takayanagi Y , Tanaka T , Ho T , Varvaris M , Tajinda K , Hiyama H , Ni K , Colantuoni C , Schretlen D , Cascella N G , Pevsner J , Ishizuka K , Sawa A 
Published: October 2016

AbstractCognitive impairment is a key feature of schizophrenia (SZ) and determines functional outcome. Nonetheless, molecular signatures in neuronal tissues that associate with deficits are not well understood. We conducted nasal biopsy to obtain olfactory epithelium from patients with SZ and control subjects. The neural layers from the biopsied epithelium were enriched by laser-captured microdissection. We then performed an unbiased microarray expression study and implemented a systematic neuropsychological assessment on the same participants. The differentially regulated genes in SZ were further filtered based on correlation with neuropsychological traits. This strategy identified theSMAD 5gene, and real-time quantitative PCR analysis also supports downregulation of the SMAD pathway in SZ. The SMAD pathway has been important in multiple tissues, including the role for neurodevelopment and bone formation. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD pathway may be a novel target in addressing cognitive deficit of SZ in future studies.
Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX
Authors: Resende L S , Amaral C E , Soares R B S , Alves A S , Alves-dos-Santos L , Britto L R G , Chiavegatto S 
Published: October 2016

AbstractMAX is a conserved constitutive small phosphoprotein from a network of transcription factors that are extensively studied in tumorigenesis and whose functions affect cell proliferation, differentiation and death. Inspired by its higher expression during development and in regions involved in emotional behaviors, we hypothesized its involvement in cerebral changes caused by early-life stress. We studied the effects of repeated social stress during adolescence on behaviors and on MAX and its putative partner MYC. Thirty-day-old C57BL/6 male mice underwent brief daily social defeat stress from an adult aggressor for 21 days. Following social stress episodes and housing in social groups after each defeat, adolescent mice exhibit depressive-like, but not anxiety-like behaviors and show higher MAX nuclear immunoreactivity in hippocampal (HC) but not prefrontal cortical (PFC) neurons. Conversely, MAX immunoreactivity is lower in the striatum (ST) of defeated adolescents. The positive correlation between MAX and MYC levels in the PFC revealed disruptions in both the HC and ST. The changes in MAX protein levels are not due to differential gene expression or protein degradation in those regions, suggesting that posttranscriptional modifications occurred. These findings indicate that repeated, brief social defeat in adolescent male mice, combined with group housing, is a useful protocol to study a subtype of depression that is dissociated from generalized (non-social) anxiety. To our knowledge, this is the first report of an association between dysregulation of the MAX-MYC network in the brain and a behavior, suggesting a novel approach for exploiting the neuroplasticity associated with depression.
Children’s word knowledge
Authors: Goldsmith Peggy 
Published: October 2016

AbstractIn regard to language learning, whether it be in listening, speaking, reading or writing, children appear to be genuinely interested In meaning in their world. When it comes to a knowledge of words to be used in any of the processes mentioned, children are interested in their use, their meaning and in connecting new words with old words or ideas.Numerous studies have investigated the development of children’s word knowledge up to year 4 or approximately age 10 (e.g. Read, 1971; Beers and Henderson, 1977; Zutell, 1979; Gentry, 1981). There are, however, only a few studies involving upper primary and secondary students. This paper looks at literature on children’s word knowledge (including spelling) development up to year 4 and beyond, and includes a table of researched and hypothesized stages in children’s development in orthographic awareness and in word knowledge. An outline of the author’s theory of children’s development in word knowledge is given.
Et à votre avis ...?
Authors: Rolin-Ianziti Jeanne , McCarthy Brian 
Published: October 2016

Abstract

Et Á votre avis...? is a text for second and third year students of French which is being prepared and piloted at the University of Wollongong. This articles provides background to the project (the approach to the text, the selection and organization of material) as well as details of tasks performed by the students in the exploitation of the linguistic and cultural components of the authentic material on which the work is based.
Event progression in Gooniyandi texts
Authors: McGregor William 
Published: October 2016

Abstract
The purpose of this paper is to explore the way in which the sequence of referent events underlying the story is expressed in narrative texts in Gooniyandi (Kimberley, Western Australia). It is shown that narratives are structured in at least two partially independent ways: in terms of story units, which constitute minimal stories (Prince, 1973)t and in terms of Complication^Peripetia Denouement. Despite the perhaps universality of these properties, there remain problems of interpretation for non-Aborigines resulting in part from differences in the types of event that constitute acceptable realizations of these functions in the different cultures.
Anaphora in children’s Warlpiri
Authors: Bavin Edith L. 
Published: October 2016

Abstract
The paper examines developmental aspects relating to how Warlpiri children introduce referents and maintain reference in narrative. Comparisons are made with the three levels of development proposed by Karmiloff-Smith, based on her work on cohesion in narrative with French- and English-speaking children. Examples are presented from children’s narratives to illustrate that Warlpiri children under six generally use ellipsis of core arguments without introducing the participants, while older children use ellipsis anaphorically, that is only after introducing the participants. The strategies for marking inter-sentence relations develop over a few years. Once the child is able to organize a narrative around a theme, there can be more flexibility in structuring the narrative.
Language and social identity
Authors: McNamara T.F. 
Published: October 2016

Abstract
The study of language attitudes and language maintenance and shift in intergroup settings has not always been related to an explicit model of the intergroup situation itself. Such a model is available in Tajfel’s Social Identity Theory. This paper explores the potential of the model for predicting and explaining language maintenance and shift among immigrant and indigenous groups in Australia. The theory forms the basis of a study of the maintenance of modern Hebrew among immigrants from Israel in Melbourne, and is used to reinterpret the findings of several other recent Australian studies.