bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management for lymphatic malformations of head and neck
Authors: Yang Weijia , Wang Huaijie , Xie Chong , Lin Weilong , Wang Peihua , Guo Zhengtuan 
Published: October 2024

BackgroundTo explore the management of lymphatic malformation in head and neck.MethodsThis is a retrospective study at a single center. Data on demographic, surgery, sclerotherapy and follow-up information were collected from our Vascular Anomalies Center database. Patients with lymphatic malformation of head and neck who had undergone surgery and sclerotherapy between March 2020 and March 2024 were included.ResultsThere were 94 patients in this study, the lesion sites included head (n = 60), tongue (n = 7), neck (n = 41), pharynx (n = 7), and head and neck (n = 7). Symptoms included bleeding (n = 6), infection (n = 2), dyspnea (n = 2), dysphonia (n = 4), and dysphagia (n = 4). Lymphatic malformation included macrocystic (n = 61), microcystic (n = 12) and mixed (n = 21). Surgeries for LM included radical resection, subtotal or partial resection and staged surgeries. Sclerotherapies included bleomycin monotherapy and combined sclerotherapy with ethanol and bleomycin, under ultrasound or fluoroscopy guidance. The follow-up period was from 3 months to 1 year. The therapeutic effect was evaluated according to the size of the treatment area. 55 patients, 21 patients, 11 patients and 7 patients were evaluated with excellent, good, moderate and no response, respectively.ConclusionSurgical resection, sclerotherapy and the combination of the two are efficacious treatment modalities for head and neck LM. Combined with oral drugs and other new therapies may be warranted in future for challenging conditions.
Global prevalence of fatigue in patients with multiple sclerosis: a systematic review and meta-analysis
Authors: Yi Xiaodong , Zhang Yue , Du Qiufeng , Kang Jing , Song Shuang , Li Tao , Jiang Yunlan 
Published: October 2024

BackgroundFatigue is one of the most common and burdensome symptoms for patients with multiple sclerosis (PwMS), considerably impacting their quality of life and employment. Numerous reports have described the prevalence of MS-related fatigue, but there is no global consensus on this matter.ObjectiveTo examine the global prevalence of MS-related fatigue and identify sources of heterogeneity in the published literature.MethodsA systematic review and meta-analysis were conducted. A comprehensive search of the PubMed, EMBASE, Cochrane Library, Web of Science, PsycINFO, CINAHL, China National Knowledge Infrastructure (CNKI), and Wanfang database for potential literature from 2000 to January 31, 2024. A random effects model was used to calculate the prevalence of MS-related fatigue. Subgroup analyses and a meta-regression were used to explore the sources of heterogeneity.ResultsSixty-nine studies from 27 countries were included. The global prevalence of MS-related fatigue was 59.1%, and it has decreased every decade since 2000. Fatigue was prevalent among females, those with lower education levels, those who were older, those with greater disability, and those with longer MS durations. The meta-regression revealed that fatigue measurement instruments were the largest source of heterogeneity.ConclusionThe prevalence of MS-related fatigue is quite high. Healthcare professionals should screen for and manage fatigue for PwMS as early as possible and pay attention to populations with a high prevalence of fatigue. The high heterogeneity among the prevalence rates due to differences in the fatigue scales suggests the importance of reaching a consensus on the best screening tools for MS-related fatigue.
Temporal and spatial analysis of event-related potentials in response to color saliency differences among various color vision types
Authors: Takahashi Naoko , Sawayama Masataka , Chen Xu , Motomura Yuki , Takeichi Hiroshige , Miyauchi Satoru , Hiramatsu Chihiro 
Published: October 2024

IntroductionHuman color vision exhibits significant diversity that cannot be fully explained by categorical classifications. Understanding how individuals with different color vision phenotypes perceive, recognize, and react to the same physical stimuli provides valuable insights into sensory characteristics. This study aimed to identify behavioral and neural differences between different color visions, primarily classified as typical trichromats and anomalous trichromats, in response to two chromatic stimuli, blue-green and red, during an attention-demanding oddball task.MethodsWe analyzed the P3 component of event-related potentials (ERPs), associated with attention, and conducted a broad spatiotemporal exploration of neural differences. Behavioral responses were also analyzed to complement neural data. Participants included typical trichromats (n = 13) and anomalous trichromats (n = 5), and the chromatic stimuli were presented in an oddball paradigm.ResultsTypical trichromats exhibited faster potentiation from the occipital to parietal regions in response to the more salient red stimulus, particularly in the area overlapping with the P3 component. In contrast, anomalous trichromats revealed faster potentiation to the expected more salient blue-green stimulus in the occipital to parietal regions, with no other significant neural differences between stimuli. Comparisons between the color vision types showed no significant overall neural differences.DiscussionThe large variability in red-green sensitivity among anomalous trichromats, along with neural variability not fully explained by this sensitivity, likely contributed to the absence of clear neural distinctions based on color saliency. While reaction times were influenced by red-green sensitivity, neural signals showed ambiguity regarding saliency differences. These findings suggest that factors beyond red-green sensitivity influenced neural activity related to color perception and cognition in minority color vision phenotypes. Further research with larger sample sizes is needed to more comprehensively explore these neural dynamics and their broader implications.
FAS gene expression, prognostic significance and molecular interactions in lung cancer
Authors: Li Kaimin , Tan Shing Cheng , Yang Zhihao , Li Chenwei 
Published: October 2024

IntroductionFAS has been implicated in the development of various cancers, but its involvement in lung cancer has not been systematically characterized. In this study, we performed data mining in online tumor databases to investigate the expression, methylation, alterations, protein interactions, co-expression and prognostic significance of FAS in lung cancer.MethodThe expression, prognostic significance and molecular interactions of FAS in lung cancer was mined and analyzed using GENT2, GEPIA2, UALCAN, cBioPortal, STRING, GeneMANIA, UCSC Xena, Enrichr, and OSluca databases. FAS expression was subsequently investigated at the protein level in samples from 578 lung cancer patients to understand its protein-level expression. In vitro validation of FAS gene expression was performed on H1299, H1993, A549 and HBE cell lines.ResultWe found that the expression of FAS was significantly downregulated in both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) compared to normal lung tissue. In addition, we observed a higher level of FAS promoter methylation in LUSC tissue than in normal tissue. FAS alterations were rare (1.9%) in lung cancer samples, with deep deletions being more common than missense mutations, which occurred mainly in the TNFR-like cysteine-rich domain and the death domain. We also identified a list of proteins interacting with FAS and genes co-expressed with FAS, with LUAD having 11 co-expressed genes and LUSC having 90 co-expressed genes. Our results also showed that FAS expression has limited prognostic significance (HR=1.302, 95% CI=0.935-1.139, P=0.530). Protein level investigation revealed that FAS expression varied among individuals, with nTPM values ranging from 5.2 to 67.2.ConclusionThis study provides valuable insights into the involvements and characteristics of FAS in lung cancer. Further studies are needed to investigate the clinical significance of FAS alterations in lung cancer and to explore the potential of targeting FAS for therapeutic intervention.
Moderating effect of sleep quality in the relationship between coping and distress among medical students
Authors: Perveen Shahida , Malik Najma Iqbal , Rehman Muhammad Ebad ur , Khan Muhammad Younas , Rehan Syeda Tayyaba , Asghar Muhammad Sohaib , Pakpour Amir H. , Griffiths Mark , Ullah Irfan , Atta Mohsin 
Published: October 2024

IntroductionThe present study examined the moderating effects of sleep quality in the relationship between coping and distress among medical college students. Present study was conducted to ensure the mental health of medical students and to dig out the reasons behind their disturbed health which can directly impact their performance at work.MethodsThe study utilized a cross-sectional survey and was distributed to students at various medical institutions in the Punjab province of Pakistan from October 2019 to June 2020. The sample comprised 369 participants (120 males; 32.5%). The survey included the Pittsburgh Sleep Quality Index (PSQI), Kessler Scale of Psychological Distress (K10), Brief Cope Scale, and Wong and Law Emotional Intelligence Scale.ResultsThe results showed there was a significant relationship between coping and distress. More specifically, adaptive coping and distress were negatively associated (r=-.24), and maladaptive coping and distress were positively associated (r=.46). Moreover, the present study found that poor sleep quality was a significant positive predictor of distress. Moderation analysis showed that sleep quality was a significant moderator in the relationship between adaptive coping and distress (ΔR2=.011, β=-.36, p&lt;.01) as well as between maladaptive coping and distress (ΔR2=.021, β=-.17, p&lt;.01).ConclusionThe study’s findings clearly showed that sleep quality is a significant moderator in the relationship between coping (both adaptive and maladaptive) and distress among medical students.
Barriers and facilitators to dissemination of non-communicable diseases research: a mixed studies systematic review
Authors: Renda Ana , Turon Heidi , Lim Michelle , Wolfenden Luke , McCrabb Sam , O’Connor Seán R. , Finch Meghan , Smith Natasha , Goraya Navdeep , Harrison Cheryce L. , Naughton Shaan , Grady Alice , Hodder Rebecca , Reilly Kathryn , Yoong Serene 
Published: October 2024

BackgroundThere is a large number of research studies about the prevention of non-communicable diseases (NCD), with findings taking several years to be translated into practice. One reason for this lack of translation is a limited understanding of how to best disseminate NCD research findings to user-groups in a way that is salient and useful. An understanding of barriers and facilitators to dissemination is key to informing the development of strategies to increase dissemination. Therefore, this review aims to identify and synthesise the barriers and facilitators to dissemination of NCD research findings.MethodsA mixed studies systematic review was performed following JBI (formerly known as Joanna Briggs Institute) methodology. The search included articles from January 2000 until May 2021. We conducted a comprehensive search of bibliographic and grey literature of five databases to identify eligible studies. Studies were included if they involved end-users of public health research that were decision-makers in their setting and examined barriers/facilitators to disseminating research findings. Two pairs of reviewers mapped data from included studies against the Framework of Knowledge Translation (FKT) and used a convergent approach to synthesise the data.ResultsThe database search yielded 27,192 reports. Following screening and full text review, 15 studies (ten qualitative, one quantitative and four mixed methods) were included. Studies were conducted in 12 mostly high-income countries, with a total of 871 participants. We identified 12 barriers and 14 facilitators mapped to five elements of the FKT. Barriers related to: (i) the user-group (n = 3) such as not perceiving health as important and (ii) the dissemination strategies (n = 3) such as lack of understanding of content of guidelines. Several facilitators related to dissemination strategies (n = 5) such as using different channels of communication. Facilitators also related to the user-group (n = 4) such as the user-groups’ interest in health and research.ConclusionResearchers and government organisations should consider these factors when identifying ways to disseminate research findings to decision-maker audiences. Future research should aim to build the evidence base on different strategies to overcome these barriers.Systematic review registrationThe protocol of this review was deposited in Open Science Framework (https://doi.org/10.17605/OSF.IO/5QSGD).
Epidemiological characterization of human infection with H5N6 avian influenza
Authors: Li Fengying , Sun Zhou , Tao Mingyong , Song Kai , Wang Zhe , Ren Xiaobin 
Published: October 2024

BackgroundIn recent years, there have been frequent reports of human infection with H5N6 avian influenza. However, the fundamental characteristics of the disease remain unclear. This paper conducts a systematic review to explore the epidemiological features of the disease, aiming to provide a foundation for epidemic prevention and control and to serve as a reference for clinical diagnosis.MethodA systematic search was performed in PubMed, Web of Science, CNKI, Wanfang and gray literature up to November 15, 2023. All articles were about the epidemic features of the H5N6 subtype of avian influenza, written in English or Chinese.ResultsThis review encompasses 24 documented outbreaks of human H5N6 avian influenza, exclusively reported in southern China. The age range of cases spanned from under 2 years old to 81 years old. The incubation period ranged from 1 to 13 days, with a mean of 4.3 days. Among the 24 cases, 22 individuals had a documented history of contact with poultry. Of the 23 cases with available prognosis data, 12 resulted in fatalities, yielding a significant fatality rate of 52.2%. A noteworthy observation is that all cases with a history of contact with sick and dead poultry resulted in fatalities, and the difference in fatality rates between this group and others was statistically significant (χ2 = 7.441, p = 0.014). This study identified a total of 888 close contacts, none of whom demonstrated infection.ConclusionThis study represents a comprehensive summary of the epidemiological characteristics of human H5N6 avian influenza. Significantly, it sheds light on the incubation period of the disease and underscores a potential elevated risk of mortality among patients with a history of contact with sick and dead poultry.
Healthy lifestyle and HPV infection risk: results from a cross-sectional study
Authors: Zhao Xi , Wu Yue , Hu Huangyu 
Published: October 2024

BackgroundHuman Papillomavirus (HPV) infection constitutes a significant global public health challenge despite the widespread implementation of vaccination programs, with infection rates persistently high. Recent studies suggest that lifestyle factors including diet quality (DQ) and physical activity (PA) could play a pivotal role in the mitigation of HPV infections. This investigation explored the influence of DQ, PA, and a healthy lifestyle on the incidence of HPV infection in adult women.MethodsData from 5,308 women aged 20–59 from the National Health and Nutrition Examination Survey (NHANES) 2007–2016. DQ and PA were measured using the Healthy Eating Index (HEI-2015) and the Global Physical Activity Questionnaire (GPAQ), respectively, creating four lifestyle groups based on how well they matched dietary and activity guidelines. The associations between key factors and HPV infection were explored using multivariate logistic regression, trend tests, and interaction tests.ResultsFully adjusted multivariable logistic regression models revealed an inverse association between the risk of HPV infection and higher levels of PA (OR = 0.914; 95% CI: 0.854–0.979) as well as DQ (OR = 0.993; 95% CI: 0.989–0.998). Individuals in the highest tertile of DQ displayed a reduced risk of HPV infection relative to those in the lowest tertile (OR = 0.846; 95% CI: 0.726–0.986). Belonging to the third quintile of PA was linked to a lower risk of HPV infection than the lowest quintile (OR = 0.823; 95% CI: 0.681–0.995). Subgroups adhering to a healthy DQ were linked to a lower risk of HPV infection irrespective of PA meeting guideline recommendations.ConclusionOur findings underscore the importance of a healthy diet in conjunction with appropriate PA in preventing HPV infection, offering new insights for public health policies and interventions.
Animal health as a function of farmer personality and attitude: using the HEXACO model of personality structure to predict farm-level seropositivity for Fasciola hepatica and Ostertagia ostertagi in dairy cows
Authors: Leinmueller Markus , Adler Friedemann , Campe Amely , Knubben-Schweizer Gabriela , Hoedemaker Martina , Strube Christina , Springer Andrea , Oehm Andreas W. 
Published: October 2024

IntroductionInfections with Fasciola hepatica and Ostertagia ostertagi impinge upon dairy cow health and welfare and represent a major economic factor in livestock industry. Control measures largely rely on the use of anthelminthic drugs. However, reports of anthelmintic resistance necessitate sustainable approaches. Farmer characteristics such as attitude and personality are crucial for the implementation of control strategies and on-farm practices.MethodsIn the present study, the HEXACO (Honesty-Humility, Emotionality, eXtraversion, Agreeableness, Conscientiousness, Openness to experience) model of personality structure, which conceptualizes human personality, was used to evaluate the relationship of farmer aspects with on-farm bulk tank milk seropositivity for F. hepatica and O. ostertagi. Moreover, information on farm structure, housing, management, and farmers’ attitude was collected in a face-to-face interview. Farm-level seropositivity for F. hepatica and O. ostertagi was predicted via elastic net regression.ResultsOut of 193 farms housing 8,774 cows in the German Federal State of Bavaria, 47 farms (24.4%) were seropositive for F. hepatica, 77 farms (39.9%) for O. ostertagi, and 42 farms (21.8%) for both endoparasites. The model for F. hepatica seropositivity selected the covariates pasture access, O. ostertagi seropositivity, higher farmer conscientiousness, and organic farming as relevant predictors. Seropositivity for O. ostertagi was predicted by F. hepatica seropositivity, pasture access, organic farming, and farmers being neutral regarding their satisfaction with animal health on their farm. Higher values for the HEXACO factors extraversion and emotionality were inversely associated with O. ostertagi seropositivity.DiscussionThe present work emphasizes the importance of farmer traits in regard to animal health and parasite occurrence. For the effective acceptance and implementation of sustainable control strategies for livestock helminth infections, it is crucial to consider these aspects to holistically address the challenges of managing parasitic diseases. Moreover, tailored communication strategies can be developed incorporating the understanding of individual stockman characteristics and subsequently ensuring encouragement of stakeholders.
Profil Pasien Cedera Anterior Cruciate Ligament (ACL) yang Menjalani Rekonstruksi ACL di RSUP Prof. Dr. R. D. Kandou Manado
Authors: Rawung Rangga B. V. , Meylia Indah , Wagiu Angelica M. J. 
Published: September 2024

Abstract: Knee injuries are among the most common sports-related injuries experienced by athletes. One of the frequently encountered knee injury is anterior cruciate ligament (ACL) tear. This study aimed to obtain the profile of patients with ACL injuries whor underwent ACL reconstruction at Prof. Dr. R. D. Kandou Hospital, Manado. This was a descriptive study with a retrospective-prospective method, using secondary data. The results obtained 16 patients who met the inclusion criteria. The incidence of ACL injuries was the highest in males (81.25%) aged 17-25 years (68.75%). The most common cause of ACL injuries was sports activities (81.25%), and many patients were classified as having first-degree obesity (37.5%). ACL injuries often occurred with meniscal injuries (56.25%). The most commonly used graft was the Hamstring (semi T) graft (43.75%). Patients typically presented within 1-6 months of the injury onset (68.75%), and the majority of knee functional outcomes were categorized as moderate (43.75%). In conclusion, anterior cruciate ligament injuries most often occur in men, aged 17-25 years. Sports activities and obesity are more at risk of ACL injury. Most ACL injuries are associated with meniscus injuries, and onsets of 1-6 months. The operative management graft that is often used is the Hamstring graft, with functional results in the middle category.
Keywords: anterior cruciate ligament injury; reconstruction; graft operative management

Abstrak: Cedera lutut merupakan salah satu cedera olahraga yang paling banyak dialami oleh atlet; salah satunya yang sering dijumpai ialah robekan anterior cruciate ligament (ACL). Penelitian ini bertujuan untuk mengetahui profil pasien cedera ACL yang menjalani rekonstruksi ACL di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif dengan pendekatan retrospektif prospektif menggunakan data sekunder. Hasil penelitian mendapatkan 16 pasien yang memenuhi kriteria inklusi. Insiden cedera ACL paling banyak terjadi pada laki-laki (81,25%), kelompok usia 17-25 tahun (68,75%), penyebab cedera karena aktivitas olahraga (81,25%), dan pasien kategori obesitas derajat 1 (37,5%). ACL sering terjadi dengan adanya cedera meniskus (56,25%), graft yang paling sering digunakan yaitu graft Hamstring (semi T) (43,75%). Sebagian besar pasien datang dengan onset kejadian 1-6 bulan (68,75%) dengan hasil fungsional lutut kategori menengah (43,75%). Simpulan penelitian ini ialah cedera ACL sering terjadi pada laki-laki berusia 17-25 tahun. Aktivitas olahraga dan obesitas berisiko terjadinya cedera ACL. Mayoritas cedera ACL berhubungan dengan cedera meniskus, onset sebagian besar pasien cedera ACL ialah 1-6 bulan, penatalaksanaan operatif dengan graft Hamstring, dengan luaran hasil fungsional kategori sedang.
Kata kunci: cedera anterior cruciate ligament; rekonstruksi; graft penatalaksanaan operatif