bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do health care workers manage a patient with multiple care needs from both health and social care services? – A vignette study
Authors: Vehko Tuulikki , Jolanki Outi , Aalto Anna-Mari , Sinervo Timo 
Published: November 2017

Introduction To assess how health care professionals outline the management of care and explore which health or social care professionals were involved in the patient's treatment. Methods A survey with a patient vignette for general practitioners (n = 31) and registered nurses (n = 31) working daily in Finnish health centres located in four cities. Respondents answered structural questions and explained in detail the care process that they tailored for the patient. The care process was examined using content analysis. Results A physician–nurse working pair was declared to be in charge of the care process by 27% of respondents, a registered nurse by 9% and a general practitioner by 11%. However, 53% reported that no single person or working pair was in charge of the care process (response rate 72%). The concluding result of the analyses of the presented process was that both treatment practices and the professionals participating in the patient's treatment varied. Collaboration with social services was occasional, and few care processes included referrals to social services. Conclusion For the patient who needs both health and social care services, the management of care is a challenge. To improve the chances of patients being actively involved in making treatment plans at least three factors need to be addressed. Firstly, a written treatment plan should explicate the care process. Second, collaboration and interaction between health and social care services should be strengthened, and third, a contact person should be named to avoid care gaps in primary health care. Next-step data from patients need to be collected to get their views on care management and compare these with those from general practitioners and registered nurses.
Serum Neurofilament Light Chain in NMOSD and Related Disorders: Comparison According to Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibodies Status
Authors: S Mariotto , A Farinazzo , S Monaco , A Gajofatto , G Zanusso , K Schanda , R Capra , C Mancinelli , A Bonora , R Bombardi , M Reindl , S Ferrari 
Published: November 2017

Background Neurofilament light chain (NF-L) levels reflect axonal damage in different conditions, including demyelinating disorders. Objectives We aimed to compare serum NF-L levels in patients with aquaporin-4 antibodies (AQP4-Ab), myelin oligodendrocyte antibodies (MOG-Ab) and seronegative cases with neuromyelitis optica spectrum disorders and related disorders. Methods We analysed AQP4-Ab and MOG-Ab with cell-based assay and NF-L with ultrasensitive electrochemiluminescence immunoassay. Results Median NF-L levels were increased in 25 AQP4-Ab-positive patients (59 pg/ml) as compared with 22 MOG-Ab-positive cases (25 pg/ml), 52 seronegative patients (18 pg/ml), 25 multiple sclerosis patients (12 pg/ml) and 14 healthy controls (12 pg/ml). Conclusions Increased serum levels of NF-L in patients with AQP4-Ab or MOG-Ab might reflect an ongoing axonal damage and a more malignant disease course.
“Hidden” Preoperative Blood Loss With Extracapsular Versus Intracapsular Hip Fractures: What Is the Difference?
Authors: Harper Katharine D. , Navo Paul , Ramsey Frederick , Jallow Sainabou , Rehman Saqib 
Published: November 2017

Purpose: Excessive blood loss with hip fracture management has been shown to result in increased rates of complications. Our goal is to compare blood loss and transfusion rates between patients with intracapsular and extracapsular (both intertrochanteric (IT) and subtrochanteric (ST)) hip fractures. Methods: 472 patients were evaluated over a five-year period. Those who presented to the hospital with a proximal femur fracture (femoral neck, IT or ST) were considered for the study. Exclusion criteria included polytrauma, gunshot injuries, periprosthetic fractures, and non-operative management. Primary endpoint was hemoglobin (Hgb) drop from admission to day of surgery (DOS); secondary endpoint was need for pre-op transfusion and discharge location. Results: 304 patients were analyzed who sustained a proximal femur fracture. Median IC Hgb drop was 0.6g/dL; median EC Hgb drop was 1.1g/dL from admission to DOS ( p = 0.0272). Rate of pre-operative transfusions was higher in EC (36/194 = 18.6%) than IC fractures (5/105 = 4.5%) ( p = 0.0006), and overall transfusion rates remained higher throughout hospital stay (55.7% EC vs. 32.7% IC; p = 0.0001). Breakdown of bleeding rate and tranfusion rates between IT and ST fractures were not significant ( p = 0.07; p = 0.4483). Extracapsular hip fractures were more likely to be discharged to a skilled nursing facility (SNF) (84.4% EC vs. 73.8% IC; p = 0.027). Conclusion: Intracapsular hip fractures have significantly less pre-operative blood loss and fewer pre-operative transfusions than their extracapsular counterparts. These findings can be used to establish appropriate pre-operative resuscitative efforts, ensuring that hip fracture protocols account for the increased likelihood of blood loss in extracapsular fractures.
Safety of transtympanic application of probiotics in a chinchilla animal model
Authors: Nhan Carol , Bezdjian Aren , Saha Shyamali , Prakash Satya , Nguyen Lily H. P. , Daniel Sam J. 
Published: November 2017

Background Chronic suppurative otitis media can be recalcitrant and difficult to treat, particularly with the increasing occurrence of antibiotic resistance. Lactobacillus plantarum is a probiotic that has been shown to decrease S. aureus and P. aeruginosa growth in wounds, making it a good candidate for the treatment of chronic suppurative otitis media. However, before it can be applied in the ear, its ototoxicity potential must be evaluated. Methods A prospective controlled trial was conducted in a chinchilla animal model at the Animal care research facilities of the Montreal Children's Hospital Research Institute to determine whether Lactobacillus plantarum is ototoxic when applied transtympanically. Ten chinchillas each had one ear randomly assigned to receive 109 CFU/mL of Lactobacillus plantarum solution, while the contralateral ear received saline. Auditory brainstem responses were measured bilaterally at 8, 20, 25 kHz before, at 7–10 days after application, and at 28 days after application of probiotic or saline. Facial nerve and vestibular function were assessed clinically. Results There were no statistically significant differences in hearing thresholds between control and experimental ears at 28 days after application. A difference of 11 dB was noted in the 25 kHz range at day 7–10, but resolved by day 28. No animals receiving probiotics developed vestibular nerve dysfunction. There was no histologic evidence of auditory hair cell damaged evidenced by scanning electron microscopy. Conclusion Our study suggests that a single application of Lactobacillus plantarum at 109 CFU/mL does not cause ototoxicity in a chinchilla animal model. These preliminary safety evaluations and the pathogen inhibitory effects of L. plantarum demonstrated by previous studies present this probiotic as a candidate of interest for further investigation.
Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study
Authors: Jabbar Karolina S. , Arike Liisa , Verbeke Caroline S. , Sadik Riadh , Hansson Gunnar C. 
Published: November 2017

Purpose Pancreatic cystic lesions are common incidental findings on imaging, but up to half may be forerunners of pancreatic cancer. Therefore, accurate differential diagnosis is crucial for correct patient management. Unfortunately, currently available diagnostic methods cannot robustly identify premalignant and malignant pancreatic cystic lesions. Methods Cyst fluid samples obtained by routine endoscopic ultrasound-guided aspiration were used for the analyses. In a cohort of 24 patients, eight biomarker candidates for malignant potential and high-grade dysplasia/cancer were identified by an explorative proteomic approach. Subsequently, a quantitative analysis, using 30 heavy-labeled peptides from the biomarkers and parallel reaction monitoring mass spectrometry, was devised, tested in a training cohort of 80, and prospectively evaluated in a validation cohort of 68 patients. End points were surgical pathology diagnosis/clinical follow-up. Diagnostic assessments were blinded to mass spectrometry results. Results The optimal set of markers for detecting malignant potential was a panel of peptides from mucin-5AC and mucin-2, which could discriminate premalignant/malignant lesions from benign with an accuracy of 97% (95% CI, 89% to 99%) in the validation cohort. This result compared favorably with the accuracy of standard analyses: cyst fluid carcinoembryonic antigen (61%; 95% CI, 46% to 74%; P < .001) and cytology (84%; 95% CI, 71% to 92%; P = .02). A combination of proteins mucin-5AC and prostate stem-cell antigen could identify high-grade dysplasia/cancer with an accuracy of 96% (95% CI, 90% to 99%), and detected 95% of malignant/severely dysplastic lesions, compared with 35% and 50% for carcinoembryonic antigen and cytology ( P < .001 and P = .003, respectively). Conclusion Targeted mass spectrometry analysis of just three cyst fluid biomarkers provides highly accurate identification and assessment of cystic precursors to pancreatic adenocarcinoma. Additional studies should determine whether the method can facilitate timely cancer diagnosis, successful intervention, and prevention.
Opowieści ormiańskie z miasteczka Kuty w tłumaczeniu na język polski wraz z komentarzami
Authors: Pisowicz Andrzej 
Published: November 2017

Armenian Tales from the Town of Kuty Translated into Polish and Annotated
The small town of Kuty on Cheremosh river was the last place in Poland where the local west Armenian dialect was spoken until World War II. Rev. Kazimierz Roszko in the 1950’s met some persons living in various places of central and western Poland who were last native speakers of the dialect. He recorded their tales in Latin transcription and published them in the annual “Folia Orientalia” (Cracow 1959, 1961) with French translation and glossaries. Now prof. Andrzej Pisowicz, a specialist in Armenian linguistics, is presenting his translation into Polish of the texts gathered and published by Rev. K. Roszko. A. Pisowicz is also commenting on some difficult words of the extinct dialect of Polish Armenians.
Subtype‐specific effects of dopaminergic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex
Authors: Leyrer‐Jackson Jonna M. , Thomas Mark P. 
Published: November 2017

AbstractIn humans, prefrontal cortical areas are known to support executive functions. In mice, these functions are mediated by homologous regions in the medial prefrontal cortex (mPFC). Executive processes are critically dependent on optimal levels of dopamine (DA), but the cellular mechanisms ofDAmodulation are incompletely understood. Stable patterns of neuronal activity may be sensitive to frequency‐dependent changes in synaptic transmission. We characterized the effects of D2 receptor (D2R) activation on short‐term excitatory postsynaptic potential (EPSP) dynamics evoked at varying frequencies in the two subtypes of layer V pyramidal neurons in mousemPFC. We isolatedNMDAreceptor and non‐NMDAreceptor‐mediated components ofEPSPtrains evoked by stimulating fibers within layer V or layer I. All significant effects of D2 receptor activation were confined to type I (corticopontine) cells. First, we found that with layer I stimulation, D2R activation reduces the amplitude ofNMDAR‐mediatedEPSPs, with no effect on facilitation or depression of these responses at lower frequencies, but leading to facilitation with high frequency stimulation. Further, the non‐NMDAcomponent also underwent synaptic depression at low frequencies. Second, with layer V stimulation, D2R activation had no effect onNMDAor non‐NMDAreceptor‐mediatedEPSPcomponents. Overall, our results suggest that D2R activation may modulate memory functions by inhibiting ‘top‐down’ influences from apical tuft inputs activated at low frequencies, while promoting ‘top‐down’ influences from inputs activated at higher frequencies. These data provide further insight into mechanisms of dopamine's modulation of executive functions.
Hydrodynamics in Indo-Pacific seagrasses with a focus on short canopies
Authors: Lanuru Mahatma , Ambo-Rappe Rohani , Amri Khairul , Williams Susan L. 
Published: November 2017

Abstract
Seagrass hydrodynamic regimes are important to understand and also to guide seagrass restoration, which is of great interest in Indonesia because of environmental threats to the exceptionally high seagrass species richness. Hydrodynamic regimes influence the physical stability of seagrass beds, sedimentation rates, and the advection of nutrients and food to seagrasses and associated organisms. In a flume, we determined the effect of canopies of Cymodocea rotundata, Enhalus acoroides, Halodule uninervis, Syringodium isoetifolium and Thalassia hemprichii on water velocity, turbulence, turbulence intensity and shear velocity. The taller canopies of Enhalus and Cymodocea slowed water flow, but the shorter canopies (<5 cm) had little effect. Seagrasses did not influence turbulence and turbulence intensity (turbulence normalized to mean velocity) but they reduced shear velocity U*. Our results indicate that Enhalus is a good candidate for transplantation in terms of reducing mean water flow and shear velocities, but that Halodule should also be considered as it also reduced shear velocities and it spreads quickly after transplantation. Our results extend the understanding of seagrass-hydrodynamic relationships to include very short canopies, unlike the taller canopies studied to date.
Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome
Authors: Shi Hui , Zheng Hui , Yin Yu-Feng , Hu Qiong-Yi , Teng Jia-Lin , Sun Yue , Liu Hong-Lei , Cheng Xiao-Bing , Ye Jun-Na , Su Yu-Tong , Wu Xin-Yao , Zhou Jin-Feng , Norman Gary L. , Gong Hui-Yun , Shi Xin-Ming , Peng Yi-Bing , Wang Xue-Feng , Yang Cheng-De 
Published: November 2017

Abstract

Background:
The aim of the study was to determine the prevalence and clinical associations of antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis and pregnancy loss in Chinese patients with antiphospholipid syndrome (APS) and seronegative APS (SNAPS).

Methods:
One hundred and eighty six Chinese patients with APS (67 primary, 119 secondary), 48 with SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s syndrome [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) and 90 healthy donors were examined. IgG and IgM aPS/PT, IgG/IgM/IgA anticardiolipin (aCL) and IgG/IgM/IgA anti-β2-glycoprotein I (anti-β2GPI) antibodies were tested by ELISA.

Results:
One hundred and sixty (86.0%) of APS patients were positive for at least one aPS/PT isotype. One hundred and thirty five (72.6%) were positive for IgG aPS/PT, 124/186 (66.7%) positive for IgM aPS/PT and 99 (53.2%) positive for both. Approximately half of the SNAPS patients were positive for IgG and/or IgM aPS/PT. Highly significant associations between IgG aPS/PT and venous thrombotic events (odds ratio [OR]=6.72) and IgG/IgM aPS/PT and pregnancy loss (OR=9.44) were found. Levels of IgM aPS/PT were significantly different in APS patients with thrombotic manifestations and those with fetal loss (p=0.014). The association between IgG/IgM aPS/PT and lupus anticoagulant (LAC) was highly significant (p<0.001). When both were positive, the OR for APS was 101.6. Notably, 91.95% (80/87) of LAC-positive specimens were positive for IgG and/or IgM aPS/PT, suggesting aPS/PT is an effective option when LAC testing is not available.

Conclusions:
Anti-PS/PT antibody assays demonstrated high diagnostic performance for Chinese patients with APS, detected some APS patients negative for criteria markers and may serve as potential risk predictors for venous thrombosis and obstetric complications.
Homogeneous precipitation synthesis of BaCO3 powders with a needle-like morphology
Authors: Chen Guo , Chen Jin , Peng Jinhui 
Published: November 2017

Abstract
Barium chloride dihydrate, sodium hydroxide and carbamide were used to prepare barium carbonate (BaCO3) powders using the homogeneous precipitation method. The effects of Ba2+ concentration, (NH2)2CO concentration, NaOH concentration, reaction temperature and reaction time on the particle size and yield of product were mainly researched. The structure and the thermal stability of BaCO3 powders prepared were analyzed using scanning electron microscopy (SEM) and thermogravimetry-differential scanning calorimetry (TG-DSC), respectively. The particle size distribution of BaCO3 powders was also characterized using a laser particle size analyzer. The results showed that the BaCO3 powder prepared has high purity with a needle-like morphology. Based on the results mentioned, this method can be applied in an effective and efficient way for BaCO3 powder preparation.
Synthesis and insecticidal activities of novel 1H-pyrazole-5-carboxylic acid derivatives
Authors: Huang Danling , Liu Aiping , Liu Weidong , Liu Xingping , Ren Yeguo , Zheng Xi , Pei Hui , Xiang Jun , Huang Mingzhi , Wang Xiaoguang 
Published: November 2017

Abstract
Fourteen 1H-pyrazole-5-carboxylic acid derivatives containing oxazole and thiazole rings were synthesized and characterized by 1H NMR, mass spectrometry and elemental analysis. Most target compounds were obtained in overall yields in the range of 30–50%. The insecticidal activities of these new compounds against Aphis fabae were evaluated. The bioassays’ results indicate that some of these compounds exhibit good activities, especially compound 7h which shows 85.7% mortality against A. fabae at a concentration of 12.5 mg/L. This activity is comparable to that of the commercial insecticide imidacloprid.
Kleine Geschichte filmischer Zwischentitel
Authors: Stenzer Christine 
Published: November 2017

AbstractIn a great many examples from the early pioneering days through to contemporary digital (video-/Internet-) productions – in the most diverse genres and countries, and in both independent and commercial contexts – intertitles and writing in the tradition of intertitles are integrated into film in such a way that the effect is by no means rigid and un-filmic, but rather, constitutes a medium that reaches far beyond what is commonly expected from writing, and writing in film.
Prevalence of dry eye disease and its association with dyslipidemia
Authors: Rathnakumar Krishnamoorthy , Ramachandran Kaliaperumal , Baba Durairaj , Ramesh Venkatachalam , Anebaracy Velusamy , Vidhya Ramachandran , Vinothkumar Rajamanickam , Poovitha Ramamurthy , Geetha Rajagopalan 
Published: November 2017

Abstract

Background:
Dry eye disease (DED) is a common ocular surface disease significantly affecting the quality of life of patients. The aim of our study is to focus on the prevalence of DED and to determine the relationship between dyslipidemia and DED.

Methods:
The study was performed with the age group of 25–70 years, who attended the ophthalmology outpatient department at Sri Lakshmi Narayana Institute of Medical Sciences with complaints of dry eye. A standard questionnaire was taken, and tear film tests were performed to diagnose dry eye. Further eyelid margin was examined to detect meibomian gland dysfunction. Based on the tests and examination, patients were grouped as men with and without DED and women with and without DED. Fasting lipid profile was investigated for these groups.

Results:
The study showed the prevalence of DED mainly in women and found significant association between DED and dyslipidemia. There is a significant relationship between total cholesterol and DED groups especially in women (p<0.001). We also found the association between triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and DED particularly in women as compared to men.

Conclusions:
Based on the findings, we emphasize that there is a strong relationship between dyslipidemia and the progression of DED particularly in women. Ophthalmologists may increase their role to educate themselves to diagnose dyslipidemia and ensure comprehensive eye care to prevent blindness and cardiovascular disease. Recent treatment modalities could be aimed to improve the quality of life of women and elderly patients suffering from DED.
Methylenetetrahydrofolate reductase gene polymorphism and clinical importance in epilepsy patients using valproic acid, carbamazepine and levetiracetam
Authors: Aydin Adem , Varoglu Asuman Orhan 
Published: November 2017

Abstract

Background:
We aim to determine the relationships among vitamin B12, folic acid, homocysteine (Hcy), and methylenetetrahydrofolatereductase (MTHFR) C677T polymorphism, as well as the clinical importance of these relationships, in patients using valproic acid (VPA), carbamazepine (CBZ), and levetiracetam (LEV) as monotherapy and polytherapy.

Methods:
We enrolled 37 patients on VPA, 30 on CBZ, 31 on LEV, 30 on multidrug therapy, and 60 control subjects. We compared the levels of vitamin B12, folic acid, Hcy and polymorphism.

Results:
Vitamin B12 was low in patients on CBZ (p=0.02) and in combined CBZ and VPA (p=0.02). B12 was low in combined CBZ and VPA (p=0.05). In patients without polymorphism, Hcy was high on VPA (p=0.02), and folic acid was the low on CBZ (0.005). In patients with polymorphism, vitamin B12 was low on CBZ (p=0.02), and folic acid was low on VPA (p=0.04). Vitamin B12 was low in combined CBZ and VPA (p=0.05).

Conclusions:
Vitamin B12 therapy is necessary on CBZ and on combined CBZ and VPA. VPA should not be used in the presence of other thrombophilic risk factors because of hyperhomocysteinemia. Polytherapy does not increase hyperhomocysteinemia risk in comparison to monotherapy. Vitamin B12, folic acid, Hcy do not effect on seizure frequency.
Investigation of the relation of maternal serum endocan levels to preeclampsia presence and severity
Authors: Gülşen Serdar , Çekmez Yasemin , Ulu İpek , Garip Şebnem , Aksoy Fatma Tutku , Türkmen Simge Bagcı , Gök Gülden , Kıran Gürkan 
Published: November 2017

Abstract

Background:
Endocan was shown to be a possible predictor of vascular endothelium related diseases. Due to this fact we aimed to investigate the role of maternal serum endocan levels in preeclampsia presence and severity.

Methods:
A total of 70 patients, including 25 normal pregnant women and 45 patients with preeclampsia (consists of 25 mild and 20 severe preeclamptic women), were included in this study. Maternal serum endocan concentrations were measured and compared among groups and subgroups.

Results:
Levels of endocan were detected statistically higher in the preeclamptic group than the control group. Endocan levels were lower in the severe preclampsia group than the mild preeclampsia group but this was not detected statistically significant.

Conclusions:
Maternal serum endocan levels can be used as a biomarker for preeclampsia presence.