bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les dispositifs de gouvernance sociale privés et leur système de contrôle: quelles réformes pour quel effet
Authors: MARX Axel , WOUTERS Jan 
Published: December 2016

RésuméCertains dispositifs privés constituent désormais une forme de gouvernance sociale mondiale qui contribue à la mise en œuvre des normes internationales du travail. Cependant, l'effet véritable de ces dispositifs sur les conditions faites aux travailleurs dans la chaîne d'approvisionnement est parfois contesté, et les systèmes d'audit utilisés dans ce cadre pour vérifier la bonne application des normes parfois jugés inadéquats. Les auteurs se demandent par conséquent comment réformer ces systèmes, en s'intéressant notamment aux mécanismes qui mettent à contribution les parties prenantes, à savoir en particulier les mécanismes de traitement des plaintes, dont ils détaillent les atouts et les limites.
Thinking families: A study of the characteristics of the workforce that delivers family‐focussed practice
Authors: Goodyear Melinda , Maybery Darryl , Reupert Andrea , Allchin Rebecca , Fraser Cait , Fernbacher Sabin , Cuff Rose 
Published: December 2016

AbstractParenting with mental illness is not uncommon and is often associated with a range of challenges for parents, children, and the family unit. Family‐focussed practice involves the provision of services to the wider family system, including children. While family‐focussed practice is important to consumers and their families, adult mental health practitioners do not routinely discuss parenting or children with their clients, nor work closely with the whole family. In the present study, we aimed to examine the characteristics of practitioners from Australian adult mental health services associated with family‐focussed practices. Characteristics included sex, years of experience, location, and previous training in child and family‐focussed practice. A total of 307 adult mental health practitioners from Victoria, Australia, responded to the Family Focused Mental Health Practice Questionnaire and a series of demographic items. The results indicated that particular practitioner characteristics predicted the delivery of family‐focussed practice. Practitioner experience, sex, working in a rural location, and previous family‐ or child‐related training were found to be important in the provision of family‐focussed practice. More experienced, female, rurally‐located, and well‐trained practitioners undertake most family‐focussed practice. These results suggest that training in family‐focussed practice needs to be promoted, with considerations made for differing needs according to the characteristics of the adult mental health practitioner.
A bibliographic exploration of nursing's scope of practice
Authors: Benton D.C. , Cusack L. , Jabbour R. , Penney C. 
Published: December 2016

AimTo conduct a bibliographic analysis of the indexed literature relating to scope of practice in nursing so as to identify underlying patterns in journal publication, volume of scholarly work over time, countries of origin, central contributors, academic affiliation and the major dimension of the studies conducted.MethodsA systematic search of the Scopus database provided data that was then extracted and utilized to undertake a bibliometric analysis of published work relating to scope of practice. In addition to identification of aggregated metrics relating to the most frequently occurring journals and most cited authors, a co‐word analysis was conducted.ResultsA total of 2730 articles with the term Scope of Practice in the Title, Abstract or Keywords were identified. Co‐word analysis revealed five major themes – Changing Regulatory Environment; Health Care Drivers; Competence & Role Implementation; Policy Context; and Role Evolution & Role Differentiation.Conclusions and policy implicationsFrom a policy perspective, we conclude that bibliographic analysis of the indexed literature is a useful technique that can augment our understanding of key regulatory issues such as scope of practice. However, the overemphasis on advanced practice in the scope of practice literature coupled with the increased interest in task shifting to support‐personnel as governments pursue the goal of universal health coverage may leave nursing inadequately prepared to inform any evidence‐based policy change.
A CAMEL DRIVER IN THE ACHAEMENID PERSIAN EMPIRE: SOCIAL NETWORK ANALYSIS OF A NON-ELITE PROFESSIONAL AND THE PERSEPOLIS FORTIFICATION ARCHIVE
Authors: SAMUELS J. TROY 
Published: December 2016

Abstract
This paper applies social network analysis in a study of the Persepolis Fortification archive to gain a more holistic picture of life in Achaemenid Persepolis. In particular, the paper focuses on translating the data from the archive into a series of network relations and visualizations and then identifying and examining a group of influential non-elites. These data allow for a particularly thorough examination of non-elite social, economic, and cultural choices. One particular non-elite individual, Dakizidda the camel driver, is used as a case study to elucidate the non-elite experience at Persepolis from a social network perspective.
MAKING SENSE OF THE WAYS WE MAKE SENSE OF THE PAST: THE PERIODO PROJECT
Authors: RABINOWITZ ADAM , SHAW RYAN , BUCHANAN SARAH , GOLDEN PATRICK , KANSA ERIC 
Published: December 2016

Abstract
The PeriodO project seeks to fill a gap in the landscape of digital antiquity through the creation of a Linked Data gazetteer of period definitions that transparently record the spatial and temporal boundaries assigned to a given period by an authoritative source. Our presentation of the PeriodO gazetteer is prefaced by a history of the role of periodization in the study of the past, and an analysis of the difficulties created by the use of periods for both digital data visualization and integration. This is followed by an overview of the PeriodO data model, a description of the platform's architecture, and a discussion of the future direction of the project.
A USER-CENTRED DESIGN TO ANNOTATE RITUAL FACTS IN ANCIENT GREEK TRAGEDIES
Authors: MUGELLI GLORIA , BOSCHETTI FEDERICO , DEL GRATTA RICCARDO , DEL GROSSO ANGELO MARIO , KHAN FAHAD , TADDEI ANDREA 
Published: December 2016

Abstract
Euporia is an annotation system developed with a user-centred approach for the study of ritual and religion in ancient Greek tragedy. Euporia adopts a domain specific language (DSL) and a lightweight web user interface in order to offer digital support to an anthropological study of ancient Greek tragedy that compares ritual as it is performed or described in Greek tragedy with ancient ritual as it can be reconstructed from literary, archaeological, and epigraphic sources. The case study discussed in this paper (Aesch. Ag. 67–71) shows one of the main features of Euporia: the ability to annotate different readings and different interpretations of the text and their consequences in the reconstruction of ancient Greek ritual.
THE AUTHORSHIP OF THE HISTORIA AUGUSTA: TWO NEW COMPUTATIONAL STUDIES
Authors: STOVER JUSTIN A. , KESTEMONT MIKE 
Published: December 2016

Abstract
The case of the Historia Augusta, a collection of imperial biographies from Hadrian to Carus supposedly written by six different authors, provided the impetus for the introduction of computational methods into the Echtheitskritik of ancient authors in 1979. After a flurry of studies in the 1990s, interest waned, particularly because most of those studies seemed to support conclusions incompatible with the scholarly consensus on the question. In the paper, we approach this question with the new tool of authorship verification – one of the most promising approaches in forensic stylometry today – as well as the established method of principal components analysis to demonstrate that there is no simple alternative between single and multiple authorship, and that the results of a computational analysis are in fact compatible with the results obtained from historical, literary, and philological analysis.
Matrine induces Akt/mTOR signalling inhibition‐mediated autophagy and apoptosis in acute myeloid leukaemia cells
Authors: Wu Junqing , Hu Gang , Dong Yuqing , Ma Ruye , Yu Zhijie , Jiang Songfu , Han Yixiang , Yu Kang , Zhang Shenghui 
Published: December 2016

AbstractPharmacological modulation of autophagy has been referred to as a promising therapeutic strategy for cancer. Matrine, a main alkaloid extracted from Sophora flavescens Ait, has antitumour activity against acute myelocytic leukaemia (AML). Whether autophagy is involved in antileukaemia activity of matrine remains unobvious. In this study, we demonstrated that matrine inhibited cell viability and colony formation via inducing apoptosis and autophagy in AML cell lines HL‐60, THP‐1 and C1498 as well as primary AML cells. Matrine promoted caspase‐3 and PARP cleavage dose‐dependently. Matrine up‐regulated the level of LC3‐II and down‐regulated the level of SQSTM1/p62 in a dose‐dependent way, indicating that autophagy should be implicated in anti‐AML effect of matrine. Furthermore, the autophagy inhibitor bafilomycin A1 relieved the cytotoxicity of matrine by blocking the autophagic flux, while the autophagy promoter rapamycin enhanced the cytotoxicity of matrine. Additionally, matrine inhibited the phosphorylation of Akt, mTOR and their downstream substrates p70S6K and 4EBP1, which led to the occurrence of autophagy. In vivo study demonstrated that autophagy was involved in antileukaemia effect of matrine in C57BL/6 mice bearing murine AML cell line C1498, and the survival curves showed that mice did benefit from treatment with matrine. Collectively, our findings indicate that matrine exerts antitumour effect through apoptosis and autophagy, and the latter one might be a potential therapeutic strategy for AML.
Protective responses of intestinal mucous cells in a range of fish–helminth systems
Authors: Bosi G , Giari L , DePasquale J A , Carosi A , Lorenzoni M , Dezfuli B Sayyaf 
Published: December 2016

AbstractHistopathological, immunofluorescence and ultrastructural studies were conducted on the intestines of four fish species infected with different taxa of enteric helminths. Brown trout (Salmo trutta trutta), eel (Anguilla anguilla) and tench (Tinca tinca) obtained from Lake Piediluco (central Italy) were examined. Brown trout and eel were infected with two species of acanthocephalans, and tench was parasitized with a tapeworm species. In addition to the above site, specimens of chub (Squalius cephalus) and brown trout infected with an acanthocephalan were examined from the River Brenta (north Italy). Moreover, eels were examined from a brackish water, Comacchio lagoons (north Italy), where one digenean species was the predominant enteric worm. All the helminths species induced a similar response, the hyperplasia of the intestinal mucous cells, particularly of those secreting acid mucins. Local endocrine signals seemed to affect the production and secretion of mucus in the parasitized fish, as worms often were surrounded by an adherent mucus layer or blanket. This is the first quantitative report of enteric worm effects on the density of various mucous cell types and on the mucus composition in intestine of infected/uninfected conspecifics. We provide a global comparison between the several fish–helminth systems examined.
Ultrastructural analysis of sequential cyprinid herpesvirus 3 morphogenesis in vitro
Authors: Monaghan S J , Bergmann S M , Thompson K D , Brown L , Herath T , del‐Pozo J , Adams A 
Published: December 2016

AbstractCyprinid herpesvirus 3 (CyHV‐3) is an alloherpesvirus, and it is the aetiological agent of koi herpesvirus disease. Although the complex morphogenic stages of the replication cycle of CyHV‐3 were shown to resemble that of other members of the Herpesvirales, detailed analysis of the sequence and timing of these events was not definitively determined. This study describes these features through a time course using cyprinid cell cultures (KF‐1 and CCB) infected with CyHV‐3 (KHV isolate, H361) and analysed by transmission electron microscopy. Rapid viral entry was noted, with high levels of intracellular virus within 1–4 h post‐infection (hpi). Intranuclear capsid assembly, paracrystalline array formation and primary envelopment of capsids occurred within 4 hpi. Between 1 and 3 days post‐infection (dpi), intracytoplasmic secondary envelopment occurred, as well as budding of infectious virions at the plasma membrane. At 5–7 dpi, the cytoplasm contained cytopathic vacuoles, enveloped virions within vesicles, and abundant non‐enveloped capsids; also there was frequent nuclear deformation. Several morphological features are suggestive of inefficient viral assembly, with production of non‐infectious particles, particularly in KF‐1 cells. The timing of this alloherpesvirus morphogenesis is similar to other members of the Herpesvirales, but there may be possible implications of using different cell lines for CyHV‐3 propagation.
Design and validation of a RT‐qPCR procedure for diagnosis and quantification of most types of infectious pancreatic necrosis virus using a single pair of degenerated primers
Authors: Vázquez D , Cutrín J M , Olveira J G , Dopazo C P 
Published: December 2016

AbstractInfectious pancreatic necrosis virus (IPNV) is an important virus which affects the salmonid aquaculture industry worldwide; therefore, it is important to develop rapid and reliable methods of diagnosis to detect the disease at early stages. Nowadays, RT‐qPCR is replacing other methods because it provides additional information on the viral load, which is important to have a better understanding of the virus replication level and of the stage of the infection and its risk level. The main problem stems from the high diversity of this virus, which can compromise the reliability of the diagnosis. In this study, we have designed an RT‐qPCR procedure for diagnosis and quantification of IPNV based on a single pair of primers targeted to segment B. The procedure has been validated, in vitro and in vivo, testing two different types of standards against seven reference strains and 23 field isolates from different types. The procedure is reliable for the detection of any type, with a detection limit of 31 TCID50 mL−1, 50 pfu mL−1 or 66 RNA copies mL−1, depending on the standard. All the standard curves showed high reliability (R2 > 0.95). The results support the high reliability of this new procedure for the diagnosis and quantification of IPNV.
Cyprinid herpesvirus 3 as a potential biological control agent for carp (Cyprinus carpio) in Australia: susceptibility of non‐target species
Authors: McColl K A , Sunarto A , Slater J , Bell K , Asmus M , Fulton W , Hall K , Brown P , Gilligan D , Hoad J , Williams L M , Crane M St J 
Published: December 2016

AbstractCarp (Cyprinus carpio L.) is a pest species in Australian waterways, and cyprinid herpesvirus 3 (CyHV‐3) is being considered as a potential biological control (biocontrol) agent. An important consideration for any such agent is its target specificity. In this study, the susceptibility to CyHV‐3 of a range of non‐target species (NTS) was tested. The NTS were as follows: 13 native Australian, and one introduced, fish species; a lamprey species; a crustacean; two native amphibian species (tadpole and mature stages); two native reptilian species; chickens; and laboratory mice. Animals were exposed to 100–1000 times the approximate minimum amount of CyHV‐3 required to cause disease in carp by intraperitoneal and/or bath challenge, and then examined clinically each day over the course of 28 days post‐challenge. There were no clinical signs, mortalities or histological evidence consistent with a viral infection in a wide taxonomic range of NTS. Furthermore, there was no molecular evidence of infection with CyHV‐3, and, in particular, all RT‐PCRs for viral mRNA were negative. As a consequence, the results encourage further investigation of CyHV‐3 as a potential biocontrol agent that is specific for carp.
Environmental Impacts of Selective Laser Melting: Do Printer, Powder, Or Power Dominate?
Authors: Faludi Jeremy , Baumers Martin , Maskery Ian , Hague Richard 
Published: December 2016

SummaryThis life cycle assessment measured environmental impacts of selective laser melting, to determine where most impacts arise: machine and supporting hardware; aluminum powder material used; or electricity used to print. Machine impacts and aluminum powder impacts were calculated by generating life cycle inventories of materials and processing; electricity use was measured by in‐line power meter; transport and disposal were also assessed. Impacts were calculated as energy use (megajoules; MJ), ReCiPe Europe Midpoint H, and ReCiPe Europe Endpoint H/A. Previous research has shown that the efficiency of additive manufacturing depends on machine operation patterns; thus, scenarios were demarcated through notation listing different configurations of machine utilization, system idling, and postbuild part removal. Results showed that electricity use during printing was the dominant impact per part for nearly all scenarios, both in MJ and ReCiPe Endpoint H/A. However, some low‐utilization scenarios caused printer embodied impacts to dominate these metrics, and some ReCiPe Midpoint H categories were always dominated by other sources. For printer operators, results indicate that maximizing capacity utilization can reduce impacts per part by a factor of 14 to 18, whereas avoiding electron discharge machining part removal can reduce impacts per part by 25% to 28%. For system designers, results indicate that reductions in energy consumption, both in the printer and auxiliary equipment, could significantly reduce the environmental burden of the process.
Gene tracing analysis reveals the contribution of neural crest‐derived cells in pituitary development
Authors: Ueharu Hiroki , Yoshida Saishu , Kikkawa Takako , Kanno Naoko , Higuchi Masashi , Kato Takako , Osumi Noriko , Kato Yukio 
Published: December 2016

AbstractThe anterior pituitary originates from the adenohypophyseal placode. Both the preplacode region and neural crest (NC) derive from subdivision of the neural border region, and further individualization of the placode domain is established by a reciprocal interaction between placodal precursors and NC cells (NCCs). It has long been known that NCCs are present in the adenohypophysis as interstitial cells. A recent report demonstrated that NCCs also contribute to the formation of pericytes in the developing pituitary. Here, we attempt to further clarify the role of NCCs in pituitary development using P0‐Cre/EGFP reporter mice. Spatiotemporal analyses revealed that GFP‐positive NCCs invaded the adenohypophysis in a stepwise manner. The first wave was detected on mouse embryonic day 9.5 (E9.5), when the pituitary primordium begins to be formed by adenohypophyseal placode cells; the second wave occurred on E14.5, when vasculogenesis proceeds from Atwell's recess. Finally, fate tracing of NCCs demonstrated that NC‐derived cells in the adenohypophysis terminally differentiate into all hormone‐producing cell lineages as well as pericytes. Our data suggest that NCCs contribute to pituitary organogenesis and vasculogenesis in conjunction with placode‐derived pituitary stem/progenitor cells.
A preliminary investigation into the morphology of oral papillae and denticles of blue sharks (Prionace glauca) with inferences about its functional significance across life stages
Authors: Rangel Bianca de S. , Wosnick Natascha , Hammerschlag Neil , Ciena Adriano P. , Kfoury Junior José Roberto , Rici Rose E. G. 
Published: December 2016

AbstractSensory organs in elasmobranchs (sharks, skates, rays) detect and respond to a different set of biotic and/or abiotic stimuli, through sight, smell, taste, hearing, mechanoreception and electroreception. Although gustation is crucial for survival and essential for growth, mobility, and maintenance of neural activity and the proper functioning of the immune system, comparatively little is known about this sensory system in elasmobranchs. Here we present a preliminary investigation into the structural and dimensional characteristics of the oral papillae and denticles found in the oropharyngeal cavity of the blue shark (Prionace glauca) during embryonic development through adulthood. Samples were obtained from the dorsal and ventral surface of the oropharyngeal cavity collected from embryos at different development stages as well as from adults. Our results suggest that development of papillae occurs early in ontogeny, before the formation of the oral denticles. The diameter of oral papillae gradually increases during development, starting from 25 μm in stage I embryos, to 110 μm in stageIVembryos and 272–300 μm in adults. Embryos exhibit papillae at early developmental stages, suggesting that these structures may be important during early in life. The highest density of papillae was observed in the maxillary and mandibular valve regions, possibly related to the ability to identify, capture and process prey. The oral denticles were observed only in the final embryonic stage as well as in adults. Accordingly, we suggest that oral denticles likely aid in ram ventilation (through reducing the hydrodynamic drag), to protect papillae from injury during prey consumption and assist in the retention and consumption of prey (through adhesion), since these processes are only necessary after birth.
Influence of the interval between antenatal corticosteroid therapy and delivery on respiratory distress syndrome
Authors: Yasuhi Ichiro , Myoga Mai , Suga Sachie , Sugimi So , Umezaki Yasushi , Fukuda Masashi , Yamashita Hiroshi , Kusuda Nobuko 
Published: December 2016

AbstractAimIn spite of the recommendation for rescue antenatal corticosteroids (ACS), the optimal time interval between primary and rescue courses has not been clearly demonstrated. The aim of this study was to determine the effects of the interval between a single ACS course and delivery on the incidence of respiratory distress syndrome (RDS).MethodsIn this retrospective study, we included singleton pregnant women who received a single course of ACS and delivered beyond 48 h after ACS administration between 24 and 33 weeks' gestation. The risk of RDS was compared between patients who delivered within seven days (Group I), 7–14 days (Group II) and beyond 14 days (Group III) after ACS administration.ResultsWe included 83, 14 and 20 patients in Groups I, II and III, respectively. After adjusting for confounders, the ACS delivery interval was significantly associated with RDS in Group II (adjusted odds ratio 12.8, 95% confidence interval 1.31–164.7) and Group III (adjusted odds ratio 64.0, 95% confidence interval 1.32–5808.6).ConclusionA longer ACS delivery interval is associated with a higher risk of RDS. Thus, the use of a rescue course could be expected to reduce the incidence of RDS in patients beyond seven days after ACS administration who remain at risk for preterm delivery within seven days, especially in cases of placenta previa and/or women bearing a male fetus.