bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mindfulness and headache: A “new” old treatment, with new findings
Authors: Andrasik Frank , Grazzi Licia , D'Amico Domenico , Sansone Emanuela , Leonardi Matilde , Raggi Alberto , Salgado-García Francisco 
Published: October 2016

Background Mindfulness refers to a host of procedures that have been practiced for centuries, but only recently have begun to be applied to varied pain conditions, with the most recent being headache. Methods We reviewed research that incorporated components of mindfulness for treating pain, with a more in depth focus on headache disorders. We also examined literature that has closely studied potential physiological processes in the brain that might mediate the effects of mindfulness. We report as well preliminary findings of our ongoing trial comparing mindfulness alone to pharmacological treatment alone for treating chronic migraine accompanied by medication overuse. Results Although research remains in its infancy, the initial findings support the utility of varied mindfulness approaches for enhancing usual care for headache management. Our preliminary findings suggest mindfulness by itself may produce effects comparable to that of medication alone for patients with chronic migraine and medication overuse. Conclusions Much work remains to more fully document the role and long term value of mindfulness for specific headache types. Areas in need of further investigation are discussed.
Influence of femtosecond laser on the osteogenetic efficiency of polyetheretherketone and its composite
Authors: Guo Jing , Liu Lijun , Liu Hong , Gan Kang , Liu Xiuju , Song Xiaoqing , Niu Deli , Chen Tianjie 
Published: October 2016

Objective: This study aimed to evaluate the effect of a femtosecond laser on the osteogenetic efficiency of polyetheretherketone (PEEK) and its composite for clinical applications. Methods: One hundred pieces of PEEK and its composite (6 × 4 × 2 mm3) were randomly divided into four groups and treated as follows: group A1, PEEK; group A2, PEEK + femtosecond laser; group B1, PEEK composite; and group B2, PEEK composite + femtosecond. The surface morphology of the pieces of each group was observed through scanning electron microscopy. The surface roughness and wettability, which were considered as the main parameters affecting cell adhesion characteristics of implants, were measured. The animals whose mandibles were implanted with the four groups of materials were killed at the end of 6 and 12 weeks. Various characterization tests, such as Cone Beam Computed Tomography (CBCT), push-out test, microscope test, and bone implant contact , were conducted to investigate the healing effect between materials and bones. Results: In group B1, the nanoparticles in PEEK were uniformly distributed. In groups A2 and B2, many periodic nanostructures were observed. The surface roughness and wettability of group B2 were significantly increased compared to those of the other groups ( p < 0.05). At each time point, the number of trabecular bones, contact strength, and BIC of group B2 were higher than those of the three other groups ( p < 0.05). Compared with those of group A1, the test results of group B1 were significantly improved. Conclusion: Femtosecond lasers can effectively enhance the biological activity of PEEK and its composite; PEEK composite exhibits better biological activity than PEEK.
Relationship between illness-related worries and social dignity in patients with heart failure
Authors: Bagheri Hossein , Yaghmaei Farideh , Ashktorab Tahereh , Zayeri Farid 
Published: October 2016

Background: Heart failure is a major growing problem and affects not only patients but also their families and community networks and reduces the functional capacity of patients and impairs their social life. Research questions: This study was conducted to investigate relationship between illness-related worries and social dignity in patients with heart failure. Design: The study had a descriptive-analytic design, and data collection was carried out by means of two specific questionnaires. Participants and context: A total of 130 inpatients from cardiac wards in hospitals affiliated with Tehran and Shahid Beheshti University of Medical Sciences participated. Ethical consideration: This study was approved by the Research Committee of Shahid Beheshti University of Medical Sciences. Results: The highest mean score of illness-related worries was attributed to the dimension of patient’s worry of physical–mental complications, and the least mean score was related to the dimension of the worry about the future of disease. The highest mean score of social dignity was associated with the dimension of social communication and support, and the least is attributed to the dimension of burden to others (economic). Pearson’s statistical test showed a significant correlation (r = 0.455, p < 0.05) between the score of illness-related worries and social dignity. Discussion: As the result of this study showed that reducing illness-related worries in patients with heart failure can improve their social dignity, using strategies to decrease worries and promote social dignity in these patients is recommended. Conclusion: This study affirms the importance of careful evaluation of individual patients to determine their needs related to dignity. We hope these results will help to promote actions by patient-care staff that honor and support patient dignity, resulting in benefits to patients and developing the quality of care based on human rights.
Impacts of Socratic questioning on moral reasoning of nursing students
Authors: Torabizadeh Camellia , Homayuni Leyla , Moattari Marzieh 
Published: October 2016

Background: Nurses are often faced with complex situations that made them to make ethical decisions; and to make such decisions, they need to possess the power of moral reasoning. Studies in Iran show that the majority of nursing students lack proper ethical development. Socratic teaching is a student-centered method which is strongly opposed to the lecturing method. Objectives: This study was conducted to evaluate the impacts of Socratic questioning on the moral reasoning of the nursing students. Research design: In a quasi-experimental study, Crisham’s Nursing Dilemma Test was used to evaluate the results of three groups before, immediately after, and 2 months after intervention. The data were analyzed using the SPSS statistical software (v 15). Participants and research context: Through random allocation, 103 nursing students were divided into three groups. In experiment group 1 (37 students), intervention consisted of Socratic questioning-based sessions on ethics and how to deal with moral dilemmas; experiment group 2 (33 students) attended a 4-h workshop; and the control group (33 students) was not subject to any interventions. Signed informed consent forms: This research was approved by the Ethics Committee of the University. All the participants signed written informed consents. Findings: There were significant differences between experiment group 1 and experiment group 2’s pre-test and post-test scores on moral reasoning (p ≤ 0.001, p ≤ 0.001), nursing principled thinking (p ≤ 0.001, p ≤ 0.001), and practical considerations (p ≤ 0.001, p ≤ 0.031). Discussion: Both the teaching approaches improved the subjects’ moral reasoning; however, Socratic questioning proved more effective than lecturing. Compared to other similar studies in Iran and other countries, the students had inadequate moral reasoning competence. Conclusion: This study confirms the need for the development of an efficient course on ethics in the nursing curriculum. Also, it appears that Socratic questioning is an effective method to teach nursing ethics and develop nursing students’ competence of moral reasoning.
Alcohol, drug and related health and wellbeing issues among young people completing an online screen
Authors: Barker S Fiona , Manning Victoria , Best David W , Savic Michael , Lubman Dan I 
Published: October 2016

Objective: Despite high levels of alcohol use, drug use and risky behaviors, rates of help-seeking amongst young people are typically low. This study explored the profile of young people (under the age of 25 years) completing an online screen, assessing substance use problem severity and wellbeing in comparison with adults completing the same screen, so as to inform development of better targeted approaches for this in-need population. Methods: Between 2012 and 2014, an online alcohol and drug screen was promoted across Australia on a national online counseling service. The screen assessed severity of substance use, mental health and wellbeing. Results: A total of 2939 screens were completed between December 2012 and May 2014, with 18% completed by young people. Young people reported a high severity of substance use problems (44% reported likely drug dependence) and reported significantly poorer mental health and wellbeing than adults completing the screen. This suggests that there is a population of young people in need of support who could be initially engaged through online screening. Conclusions: Online screening should be a key component of engagement strategies for adolescent and early adult help-seeking.
Transition in ADHD: attention to the lifespan
Authors: Poulton Alison S 
Published: October 2016

Objectives: This paper reviews the importance of transition to adult services for young people with ADHD. Method: Different models are described and evidence sought for their effectiveness in clinical practice. Results: Models of care for children with ADHD include specialised mental health services, individual paediatricians and child and adolescent psychiatrists. Although it might be expected that transition would be to equivalent adult teams or specialists, studies have shown that transition may not run smoothly, and the adult services are frequently inadequate. This may result in attrition from treatment or discharge to the general practitioner. Conclusions: Adult mental health services for transitioning young people with ADHD are under-resourced. The way forward may be a generic ADHD specialist or service, treating ADHD across the lifespan and avoiding the need for transition.
Increased detection of Dirofilaria immitis antigen in cats after heat pretreatment of samples
Authors: Gruntmeir Jeff M , Adolph Chris B , Thomas Jennifer E , Reichard Mason V , Blagburn Byron L , Little Susan E 
Published: October 2016

Objectives To determine whether pretreating diagnostic samples with heat increases the detection of Dirofilaria immitis antigen in adult cats, we evaluated feline serum and plasma samples collected in heartworm-endemic areas of the southern United States. Methods Commercial microtiter well assays for detection of D immitis antigen were used to evaluate serum or plasma samples from 385 shelter and free-roaming cats from the southcentral and southeastern United States before and after heat treatment; commercial antibody tests were performed on a subset of samples. Results Prior to sample heat treatment, 1/220 (0.5%) shelter cats and 4/165 (2.4%) free-roaming cats had detectable D immitis antigen. After heat pretreatment, the detection rate increased to 13/220 (5.9%) and 13/165 (7.9%), respectively. Antibody reactive to D immitis was significantly more common ( P <0.001) in the serum of cats that were antigen positive after heat treatment (10/13; 76.9%) than serum from cats that remained antigen negative after heat treatment (22/163; 13.5%). Conclusions and relevance Heat pretreatment of feline samples increased antigen detection by commercial assays for D immitis and improved overall concordance of antigen and antibody test results in antigen-positive samples in this population. Although further work to investigate the specificity of D immitis antigen assays when using pre-treated samples is warranted, this approach may be useful in the diagnosis of heartworm infection in individual cats and may increase the accuracy of surveys based on antigen detection.
Strategies to prevent TEVAR-related spinal cord ischemia
Authors: Dias-Neto Marina , Reis Pedro Videira , Rolim Dalila , Ramos José Fernando , Teixeira José Fernando , Sampaio Sérgio 
Published: October 2016

Spinal cord ischemia remains the Achilles’ heel of thoracic and thoracoabdominal diseases management. Great improvements in morbidity and mortality have been obtained with the endovascular approach TEVAR (Thoracic Endovascular Aortic Repair) but this devastating complication continues to severely affect the quality of life, even if the primary success of the procedure – dissection/aneurysm exclusion – has been achieved. Several strategies to deal with this complication have been published in the literature over the time. Knowledge and technology have been evolving from identification of the risk factors associated with spinal cord ischemia, including lessons learned from open surgery, and from developments in the collateral network concept for spinal cord perfusion. In this comprehensive review, the authors cover several topics from the traditional measures comprising haemodynamic control, cerebrospinal drainage and neuroprotective drugs, to the staged-procedures approach, the emerging MISACE (minimally invasive selective segmental artery coil-embolization) and innovative neurologic monitoring such as NIRS (near-infrared spectroscopy) of the collateral network.
Stroke Epidemiology in an Australian Rural Cohort (SEARCH)
Authors: Newbury Jonathan , Kleinig Tim , Leyden James , Arima Hisatomi , Castle Sally , Cranefield Jennifer , Paterson Tracey , Jannes Jim , Crotty Maria , Anderson Craig S 
Published: October 2016

Background Stroke rates in Australia and New Zealand have been declining since 1990 but all studies have been completed in large urban centers. Aim We report the first Australasian stroke incidence study in a rural population. Methods The authors applied the principle of complete ascertainment, used the WHO standard definition of stroke and classified ischemic stroke by the TOAST criteria. Data were collected from five rural centers defined by postcode of residence, over a 2-year period with 12 months of follow up of all cases. Results There were 217 strokes in 215 individuals in a population of 96,036 people, over 2 years, giving a crude attack rate of 113 per 100,000 per year. The 181 first-ever strokes (83% of total), standardized to the WHO world population, occurred at a rate of 50/100,000 (95% CI: 43–58). The 28-day fatality for first-ever strokes was 24% (95% CI: 18–31) and 77% (95% CI: 71–83) were classified as ischemic (140/181), 15% (95% CI: 10–21) intracerebral hemorrhage, 3% (95% CI: 1–6) due to subarachnoid hemorrhage and 5% (95% CI: 2–9) were unknown. A high proportion of first-ever ischemic strokes (44%) were cardioembolic, mostly (77%) due to atrial arrhythmias. Of the 38 with known atrial arrhythmias prior to stroke, only six (16%) were therapeutically anticoagulated. Conclusions This rural companion study of a recent Australian urban stroke incidence study confirms the downward trend of stroke incidence in Australia, and reiterates that inadequate anticoagulation of atrial arrhythmia remains a preventable cause of ischemic stroke.
A methodology for model-based verification of safety contracts and performance requirements
Authors: Gómez-Martínez Elena , Rodríguez Ricardo J , Benac-Earle Clara , Etxeberria Leire , Illarramendi Miren 
Published: October 2016

The verification of safety requirements becomes crucial in critical systems where human lives depend on their correct functioning. Formal methods have often been advocated as necessary to ensure the reliability of software systems, albeit with a considerable effort. In any case, such an effort is cost-effective when verifying safety-critical systems. Often, safety requirements are expressed using safety contracts, in terms of assumptions and guarantees. To facilitate the adoption of formal methods in the safety-critical software industry, we propose a methodology based on well-known modelling languages such as the unified modelling language and object constraint language. The unified modelling language is used to model the software system while object constraint language is used to express the system safety contracts within the unified modelling language. In the proposed methodology a unified modelling language model enriched with object constraint language constraints is transformed to a Petri net model that enables us to formally verify such safety contracts. The methodology is evaluated on an industrial case study. The proposed approach allows an early safety verification to be performed, which increases the confidence of software engineers while designing the system.
Heart rate at admission is a predictor of in-hospital mortality in patients with acute coronary syndromes: Results from 58 European hospitals: The European Hospital Benchmarking by Outcomes in acute coronary syndrome Processes study
Authors: Jensen Magnus T , Pereira Marta , Araujo Carla , Malmivaara Anti , Ferrieres Jean , Degano Irene R , Kirchberger Inge , Farmakis Dimitrios , Garel Pascal , Torre Marina , Marrugat Jaume , Azevedo Ana 
Published: October 2016

Aims: The purpose of this study was to investigate the relationship between heart rate at admission and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: Consecutive ACS patients admitted in 2008–2010 across 58 hospitals in six participant countries of the European Hospital Benchmarking by Outcomes in ACS Processes (EURHOBOP) project (Finland, France, Germany, Greece, Portugal and Spain). Cardiogenic shock patients were excluded. Associations between heart rate at admission in categories of 10 beats per min (bpm) and in-hospital mortality were estimated by logistic regression in crude models and adjusting for age, sex, obesity, smoking, hypertension, diabetes, known heart failure, renal failure, previous stroke and ischaemic heart disease. In total 10,374 patients were included. Results: In both STEMI and NSTE-ACS patients, a U-shaped relationship between admission heart rate and in-hospital mortality was found. The lowest risk was observed for heart rates between 70–79 bpm in STEMI and 60–69 bpm in NSTE-ACS; risk of mortality progressively increased with lower or higher heart rates. In multivariable models, the relationship persisted but was significant only for heart rates >80 bpm. A similar relationship was present in both patients with or without diabetes, above or below age 75 years, and irrespective of the presence of atrial fibrillation or use of beta-blockers. Conclusion: Heart rate at admission is significantly associated with in-hospital mortality in patients with both STEMI and NSTE-ACS. ACS patients with admission heart rate above 80 bpm are at highest risk of in-hospital mortality.
Life-threatening haematological complication occurring in a cat after chronic carbimazole administration
Authors: Mosca Andrea , Bresciani Luca 
Published: October 2016

Case summary An 11-year-old spayed female domestic shorthair cat with a history of hyperthyroidism treated with carbimazole for 7 months was presented for a check-up after a few episodes of vomiting. The cat had been receiving prednisolone at 0.5 mg/kg PO q12h for recent pancreatitis and concurrent inflammation of liver and small intestines confirmed by biopsies. Clinical examination revealed pale mucous membranes with a capillary refill time of <2 s. Haematology showed severely decreased packed cell volume (16%), and increased prothrombin time (42 s), partial thromboplastin time (>120 s) and fibrinogen serum concentration (3.5 g/l). Morphological changes of thrombocytes in the absence of thrombocytopenia were also noted. In-saline agglutination test was positive. Abdominal radiographic and ultrasonographic examinations excluded the presence of organ abnormalities and peritoneal effusion. Blood biochemistry was unremarkable. Feline leukaemia virus and feline immunodeficiency virus tests were negative. On the basis of these findings, immune-mediated anaemia secondary to chronic carbimazole administration was suspected. Prednisolone was increased to 2 mg/kg PO q24h and carbimazole tablets were stopped. Despite close monitoring and intensive care, the cat died the same evening of admission to the hospital. Relevance and novel information This report suggests that severe haemotoxicity may occur as a sequel of chronic carbimazole administration in cats. Routine bloodwork and accurate follow-up of cats under treatment with thyrotoxic therapy may be advisable, in order to detect haematological changes before lethal complications occur.
Scapular osteomyelitis in an immature domestic shorthair cat
Authors: Viskjer Sivert , Rapp Martin 
Published: October 2016

Case summary A 12-week-old, male, domestic shorthair cat was presented with severe left thoracic limb lameness. Investigation included physical examination, diagnostic imaging with radiography and CT, histopathology and microbiological culture. Physical examination revealed a large, firm mass on the left scapula. Radiography and CT showed a monostotic spherical expansile bone lesion in the infraspinatus fossa of the left scapula. The histopathological description was a central acute suppurative osteomyelitis with reactive fibrosis and new bone formation at the periphery. Aerobic and anaerobic cultures were negative and the underlying cause of the osteomyelitis could not be identified. The use of broad-spectrum antibiotics for 8 weeks proved effective with full clinical recovery and no signs of relapse during the follow-up time of 8 months. Relevance and novel information This report describes the management and outcome of a rare case of osteomyelitis with severe deformation of scapular bone morphology in an immature cat that was treated successfully with full recovery of limb function and restored integrity of the scapula.
Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis
Authors: Ludwig Michael D , Turel Anthony P , Zagon Ian S , McLaughlin Patricia J 
Published: October 2016

Introduction A retrospective study was conducted on patients at Penn State Hershey Medical Center diagnosed with relapsing–remitting multiple sclerosis between 2006 and 2015. Methodology Laboratory and clinical data collected over this 10-year period were reviewed. Two cohorts of patients were established based on their relapsing–remitting multiple sclerosis therapy at the time of their first visit to Penn State. One group of patients ( n = 23) was initially prescribed low dose naltrexone at the time first seen at Hershey. This group was offered low dose naltrexone because of symptoms of fatigue or refusal to take an available disease-modifying therapy. The second group of patients ( n = 31) was treated with the glatiramer acetate (Copaxone) and offered low dose naltrexone as an adjunct therapy to their disease-modifying therapy. Results Patient data from visits after 1–50 months post-diagnosis were evaluated in a retrospective manner. Data obtained from patient charts included clinical laboratory values from standard blood tests, timed 25-foot walking trials, and changes in magnetic resonance imaging reports. Statistical analyses between the groups and for each patient over time indicated no significant differences in clinical laboratory values, timed walking, or changes in magnetic resonance imaging. Conclusion These data suggest that the apparently non-toxic, inexpensive, biotherapeutic is safe and if taken alone did not result in an exacerbation of disease symptoms.