bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pendidikan Kewirausahaan, Kebijakan Pemerintah Dan Dukungan Sosial Terhadap Intensi Berwirausaha Mahasiswa Di Universitas Negeri Jakarta
Authors: Taufik Irwansyah  , Shofiany  , Agus Wibowo  , Karuniana Dianta Arfiando Sebayang  
Published: October 2024

Penelitian ini bertujuan untuk menguji pengaruh pendidikan kewirausahaan, kebijakan pemerintah, dan dukungan sosial terhadap niat berwirausaha mahasiswa di Universitas Negeri Jakarta. Mengingat pentingnya kewirausahaan dalam mendorong perekonomian dan menciptakan lapangan kerja, penelitian ini berfokus pada faktor-faktor yang dapat meningkatkan minat mahasiswa untuk berwirausaha. Sampel penelitian terdiri dari 672 mahasiswa yang dipilih secara acak, memberikan gambaran yang representatif dari populasi mahasiswa di universitas. Teknik analisis data yang digunakan adalah Structural Equation Modelling Partial Least Square (SEM-PLS), yang memungkinkan analisis komprehensif terhadap hubungan antara variabel independen dan dependen. Temuan penelitian menunjukkan bahwa pendidikan kewirausahaan memiliki pengaruh positif dan signifikan terhadap intensi berwirausaha. Pendidikan kewirausahaan yang diberikan di kampus mampu meningkatkan pengetahuan, keterampilan, dan kepercayaan diri mahasiswa untuk memulai bisnis. Selain itu, kebijakan pemerintah yang mendukung kewirausahaan, seperti pemberian insentif, akses permodalan, dan regulasi yang ramah bisnis, terbukti secara signifikan meningkatkan intensi berwirausaha mahasiswa. Dukungan sosial, baik dari keluarga, teman, maupun lingkungan sekitar, berperan penting dalam memotivasi mahasiswa untuk berwirausaha. Dukungan ini memberikan motivasi, bantuan moral, dan jaringan yang diperlukan dalam proses kewirausahaan. Penelitian ini menegaskan bahwa untuk meningkatkan intensi berwirausaha di kalangan mahasiswa, diperlukan sinergi antara pendidikan kewirausahaan yang efektif, kebijakan pemerintah yang mendukung, dan dukungan sosial yang kuat. Temuan ini diharapkan dapat menjadi referensi bagi universitas, pemerintah, dan masyarakat dalam merancang strategi dan program yang dapat mendorong semangat kewirausahaan di kalangan generasi muda. Sebagai hasilnya, diharapkan akan ada peningkatan jumlah pengusaha muda yang memiliki kemampuan inovatif dan dapat memberikan dampak positif bagi perekonomian negara.
The Influence of Stress Management and Public Speaking through Academic Achivement
Authors: Nurul Husna  
Published: October 2024

This study aims to analyze the influence of stress management and public speaking on the academic achievement of students. This research was conducted using a quantitative method, with a sample of 35 students with accidental sampling. Data were collected through structured questionnaires and analyzed using multiple linear regression techniques. The results of the study show that Stress Management and Public Speaking, can influence the dependent variable, namely Academic Achivement, by 42,2%, while other variables outside this study influence the remaining 57,8%. The implications of this study are the importance for students to improve their stress management and public speaking skills. This can be done by attending training or seminars, as well as by practicing stress management and public speaking techniques in daily life.
Increasing Diversity in Orthopaedic Surgery Residency
Authors: Owuor Hans K. , Strauss Eric J , McLaurin Toni , Zuckerman Joseph D , Egol Kenneth A. 
Published: October 2024

Introduction:
African American, Hispanic, Asian, and Pacific Islanders are groups who are underrepresented in medicine (URM groups). Similarly, although women comprise more than 50% of medical students in the United States, women comprise a smaller percentage of all orthopaedic surgery trainees. Therefore, underrepresented in orthopaedics (URiO) represents the URM groups and women. The purpose of this study is to examine the impact of specific steps to recruit a qualified, diverse trainee complement within a single academic orthopaedic surgery residency program between 2000 and 2023. We aim to explore changes in the representation of URiO during this period as well as explore the strategies and programs implemented by the department that may have impacted recruitment of a diverse complement of trainees.

Methods:
Match lists from a large, academic, orthopaedic surgery residency between 2000 and 2023 were collected and reviewed for racial and gender data. Match lists were then divided into 6-year quantiles to identify any trends in the recruitment of URiO students. Self-reported racial and gender data from Electronic Residency Application Service applicant reports and the Accreditation Council for Graduate Medical Education (ACGME) data books between 2018 and 2022 were collected and reviewed. In addition, the department's strategies implemented during the study period with the goal of enhancing URiO exposure to orthopaedic surgery were also explored.

Results:
The department implemented proactive strategies to increase exposure to orthopaedic surgery for URiO students. An increase in URiO representation was noted between 2000 and 2023 with Hispanic, Black/African American, and Native Hawaiian/Pacific Islander resident representation increasing by 5%, 11%, and 1%, respectively. In addition, women representation increased by 27% between 2000 and 2023. The overall attrition rate among URiO residents was 1% with only one resident not completing the program. Self-reported racial and gender data from ACGME data books demonstrated that Black/African American, Hispanic, and Native Hawaiian/Pacific Islander residents comprised 5%, 4%, and 0.04%, respectively, of orthopaedic surgery residents between 2018 and 2022.

Conclusions:
These results provide insight for other programs to use similar strategies to potentially improve recruitment, retain, and provide support to URiO residents.
Dietary Citrulline Supplementation Enhances Milk Production in Lactating Dairy Goats
Authors: Lopez Arianna , Newton Makenzie , Stenhouse Claire , Connolly Erin , Hissen Karina , Horner Scott , Wu Guoyao , Foxworth William , Bazer Fuller 
Published: October 2024

Abstract

Background Nutrition, day of lactation, litter size, parity, and sire impact lactational performance in goats. Arginine (Arg) has important roles in synthesis of nitric oxide (NO), polyamines, and creatine. Ruminal microbes degrade extracellular Arg; however, extracellular Cit is not degraded by ruminal microbes and can be fed unencapsulated as a proxy for Arg. Cit is absorbed in the small intestine, converted to Arg, then metabolized to NO, polyamines and creatine that may enhance lactational performance. This study determined effects of dietary citrulline (Cit) supplementation on milk production and milk composition of Alpine dairy goats. Does were synchronized to estrus and bred to Alpine bucks. Parturition was induced on Day 149 of gestation. After kidding, does were suckled overnight to allow their kid(s) to obtain colostrum before being milked 24h later (Day 1 of lactation). Does were assigned to either control (CON, n = 24) or citrulline (CIT, n = 23) supplemented diets. The isonitrogenous control diet was supplemented with 1.37% alanine and 1.00% soybean hydrogenated oil. The CIT supplemented diet was 97.63% basal diet with a 2.37% supplement (0.5% Cit, 0.5% Glutamine, 1% soybean hydrogenated oil, and 0.37% cornstarch). Diets were group fed ad-libitum by treatment group. Blood samples were collected on Days 0 and 30 of lactation, and daily milk volumes were collected twice daily. On Days 10, 20, and 40 of lactation, milk samples were collected for compositional analyses.
Results CIT-treated does had greater mean daily milk production (P = 0.0332) and there was an effect of day of lactation on mean daily milk production (P < 0.0001). Does producing three kids had greater mean daily milk production than does producing one kid (P<0.001). Multiparous does had greater mean daily milk production than primiparous does (P<0.0001), and there was an effect of sire on mean daily milk production (P<0.05). Compositional analyses revealed that Cit supplementation increased soluble-non-fat (SNF) (P= 0.0189) and protein (P=0.0238) in milk.
Conclusions Dietary supplementation of Cit fed ad-libitum increased mean daily milk yield and impacted milk composition in Alpine does. Further investigations should seek to understand underlying mechanisms responsible for these effects.
Exploring the cytotoxic effects of bioactive compounds from Alcea rosea against stem cell-driven colon carcinogenesis: A Scientific Interpretation and Validation of Indigenous Knowledge
Authors: Parry Ruhban Ansar , Mir Irfan Ahmad , Hussain Mahboob Ul , Ashraf Suhail , Ganie Showkat Ahmad , Vats Sharad 
Published: October 2024

Abstract

Seven compounds were isolated from ethyl acetate extract of Alcea rosea and were examined for their cytotoxicity against HCT116 and HT29 colon cancer cells. It was found that two compounds (C4 and C5) exhibited strong anti-colon cancer activities. These two compounds were used to study their properties that include MTT activity, colony formation activity, wound healing activity, spheroid formation activity, DAPI-PI staining, acridine-orange and ethidium bromide staining, ROS measurement, and rhodamine-123 staining in both HCT116 and HT29 colon cancer cells. Both the compounds showed significant increase in apoptosis as visualized by DAPI-PI and AO-ETBR staining. The induction of apoptosis was further confirmed by the expressions of cleaved PARP and caspase 3. ROS generation and its effect on MMP were measured by staining cells with DCFH-DA and Rhodamine. Expression levels of EMT associated markers like Cyclin D1, Slug, Vimentin, and E-Cadherin were also studied. Both the compounds down regulate protein levels of Slug, Cyclin D1, and Vimentin in a concentration-dependent manner. Eeffect of C4 and C5 compounds on key signaling protein like Wnt3a, Notch1, and Shh were evaluated. Additionally, mRNA levels of these genes were also analyzed. C4 exhibited the best binding affinity when docked with Shh and Wnt3a and Notch1. Similarly, C5 exhibited - 8.8, -8.2 and -7.6 kcal⋅mol−1 with Shh, Wnt3a and Notch1. The present findings provide insight and immense scientific support and integrity to a piece of indigenous knowledge. However, validation in living organisms is necessary before progressing to clinical trials and advancing it into a marketable pharmaceutical product.
­Clayey Soil Stabilization with Ordinary Portland Cement Using the Stabilized Soil as A Mortar
Authors: Rehman Ziaur , Fang Xu , Rauf Muhammad , Chaozhe Jiang 
Published: October 2024

Abstract

The purpose of this research is to investigate how cement influences clayey soil stabilization. There is clayey soil around the world, but it is particularly prevalent in Pakistan. Khyber Pakhtunkhwa (KPK). In the KPK province, we chose four various sites, took soil samples, and determined the index properties of the soil. From the sieve analysis test result, 44.28 percent of the total sample passed through sieve No. 200. It indicates that the soil is clayey. Although there are various techniques for stabilizing clayey soil. In this research, for the stabilization of clayey soil, cement is utilized as a stabilizing material. We focused on mixing clayey soil with cement in different percentages, which can be converted to acceptable construction material, particularly in rural areas of Pakistan. In the past, low-rise masonry constructions usually utilized mud mortar. If clay is present in the soil mortar, issues such as excessive swelling or shrinkage and high plasticity can arise. To minimize this effect, it is essential to stabilize the mud mortar. Various laboratory tests on clayey soil were conducted both with and without the addition of cement, and their effects on the clayey soil properties were observed. A dry density test and unconfined compression test were applied for evaluation of this admixing. Utilizing the technique of soil stabilization as a cost-effective alternative to fine aggregates, low-cost housing can be constructed in rural areas by using the stabilized soil as mortar. This research will give a strong economic foundation for low-cost construction.
Real-world evidence for altered communication patterns in individuals with autism spectrum disorder
Authors: Turna Mehran , Eckert Johannes , Meier-Böke Kristina , Narava Mamaka , Chaliani Irini , Eickhoff Simon , Schilbach Leonhard , Dukart Juergen 
Published: October 2024

Abstract

Adults with high-functioning autism (HFA) may compensate for their social difficulties by resorting to more sequential forms of communication. Here, we study communication preferences in individuals with HFA and neurotypical controls by monitoring smartphone-based communication for verbal, written and mixed app categories over a period of four months. We find HFA participants to prefer written over verbal communication, underscoring the importance of considering these preferences to facilitate social integration
Q-learning Based Tree Structure Encoding Discrete Symbiotic Organisms Search Algorithm to Solve Shop Scheduling Problem
Authors: Li Jun , Liu Xichen , Zhang Qiwen 
Published: October 2024

Abstract

Based on the practical scheduling situation, this paper considers the effect of learning effect on scheduling and the learning threshold of jobs, and designs a learning effect no-wait scheduling model based on position truncation. A Q-learning based tree structure encoded discrete symbiotic organism search (QDTSEDSOS) algorithm is proposed for the scheduling problem, which first transforms feasible solutions into a tree structure more suitable for representing complex problems to improve search efficiency and expand solution space. Secondly, in the mutualism phase, the "advantageous block" of jobs is preserved to improve global optimization ability. In addition, the population is divided into superior and inferior subpopulations based on the distribution characteristics of particles. The superior subpopulation proposes three neighborhood search strategies to deal with the "large valley" phenomenon and uses Q-learning to utilize the results and information of historical search in order to guide the current search process. The solution space is searched more efficiently by selecting operators based on prior experience, while the inferior subgroup performs a parasitic strategy based on backward connectivity to purposely explore promising individuals. Experimental results on the Taillard benchmark set show that QDTSEDSOS is feasible and effective in solving the learning effect-based no-wait flow shop scheduling problem.
Fluoroquinolone-Specific Resistance Trajectories in E. coli and their Dependence on the SOS-Response
Authors: Teichmann Lisa , Luitwieler Sam , Bengtsson-Palme Johan , Kuile Benno ter 
Published: October 2024

Abstract

Background
Fluoroquinolones are indispensable antibiotics used in treating bacterial infections in both human and veterinary medicine. However, resistance to these drugs presents a growing challenge. The SOS response, a DNA repair pathway activated by DNA damage, is known to influence resistance development, yet its role in fluoroquinolone resistance is not fully understood. This study aims to unfold the mechanisms of fluoroquinolone resistance by investigating the impact of the SOS response on bacterial adaptation.
Results
We exposed Escherichia coli to four fluoroquinolones - ciprofloxacin, enrofloxacin, levofloxacin, and moxifloxacin. Using a recA knockout mutant, deficient in the SOS response, as a control, we assessed how the presence or absence of this pathway affects resistance development. Our findings demonstrated that the rate of resistance evolution varied between the different fluoroquinolones. Ciprofloxacin and moxifloxacin exposures led to the most evident reliance on the SOS response for resistance, whereas enrofloxacin and levofloxacin exposed cultures showed less dependency. Whole genome analysis indicated distinct genetic changes associated with each fluoroquinolone, highlighting potential different pathways and mechanisms involved in resistance.
Conclusions
This study shows that the SOS response plays a crucial role in resistance development to certain fluoroquinolones, with varying dependencies per drug. The characteristic impact of fluoroquinolones on resistance mechanisms emphasizes the need to consider the unique properties of each antibiotic in resistance studies and treatment strategies. These findings are essential for improving antibiotic stewardship and developing more effective, tailored interventions to combat resistance.
Evaluation of Response to Hepatitis B Vaccination in Patients on Maintenance Haemodialysis: Insights From a Satellite Hemodialysis Unit in Kenya
Authors: Kevin Nguring'a , Twahir Ahmed , McLigeyo Seth , Maranga Wambugu , Hadi Abdullahi 
Published: October 2024

Abstract

INTRODUCTION
Patients with end-stage renal disease (ESRD) on maintenance haemodialysis (HD) are at an increased risk of acquiring hepatitis B virus (HBV) infection. Active HBV immunization in these patients is recommended. A response rate in HD patients is variable but generally lower than healthy individuals.
OBJECTIVES
The aim of this study was to evaluate the response of hepatitis B vaccination and to correlate response to various clinical and biomedical factor in patients on maintenance haemodialysis (HD) followed up at parklands kidney centre, Kenya.
METHODOLOGY
This was a retrospective study conducted between 1st January 2023 to 1st January 2024 at Parklands Kidney Center, renal unit, Nairobi. The study population was adults aged 18 years and above who were undergoing maintenance haemodialysis. They should have received at least 40 μg of HBV vaccine administered intramuscularly in the deltoid region at 0, 1, 2 and 6 months. The patients' responses to vaccine was determined by the measured hepatitis B surface antibody (HBsAb) done 6 to 12 weeks after the last injection. Data of patients undergoing maintenance HD was extracted using a data collection tool.
RESULTS
Ninety-two patients (78 %) mounted a response with HBsAb >10 mIU/ml and thus were considered as adequate responders. Sixty-four (54.24 %) patients mounted an excellent response with HBsAb >100 mIU/ml. Twenty-six patients (22.03 %) were non-responders. A young age (P = 0.017), diabetes mellitus (0.008), duration of dialysis (0.032), and Urea Reduction Ratio (<0.001) predicted a positive response to HB vaccination. Gender, haemoglobin level, serum albumin, serum ferritin, parathyroid hormone level, C reactive protein and vitamin D had no effect on the response to vaccine. In addition, out of the 118 (100 %) patients on maintenance HD all were HBsAg negative, of those tested for HbcAb 25 (32 %) were positive an indication of occult hepatitis B infection.
CONCLUSION
A 78 % response rate to HB vaccine was observed in the cohort of this study. Young age, diabetes mellitus, duration of dialysis and urea reduction ratio predicts a favourable response to HBV vaccine in patients on maintenance HD.
Modeling of Bayesian Machine Learning with Sparrow Search Algorithm for Cyberattack Detection in IIoT Environment
Authors: Karim Faten Khalid , Varela-Aldás José , Ishak Mohamad Khairi , Aljarbouh Ayman , Mostafa Samih M. 
Published: October 2024

Abstract

With the fast-growing interconnection of smart technologies, the Industrial Internet of Things (IIoT) has revolutionized how the industries work by connecting devices and sensors through automating regular operations via the Internet of Things (IoTs). IoT device provides seamless diversity and connectivity in different application domains. This system and its transmission channels are subjected to targeted cyberattacks due to their round-the-clock connectivity. Accordingly, a multilevel security solution is needed to safeguard the industrial system. By analyzing the data packet, the Intrusion Detection System (IDS) counteracts the cyberattack for the targeted attack in the IIoT platform. Various research has been undertaken to address the concerns of cyberattacks on IIoT networks using machine learning (ML) and deep learning (DL) approaches. This study introduces a new Bayesian Machine Learning with the Sparrow Search Algorithm for Cyberattack Detection (BMLSSA-CAD) method in the IIoT networks. The proposed BMLSSA-CAD technique mainly intends to improve security in the IIoT network via the detection of cyberattacks. In the BMLSSA-CAD technique, the min-max scalar can be used to normalize the input dataset. Besides, the BMLSSA-CAD method involves a chameleon optimization algorithm (COA) based feature selection approach to elect an optimum feature set. The BMLSSA-CAD technique uses the Bayesian Belief Networks (BBN) model for cyberattack detection. The parameter tuning process was executed by using the sparrow search algorithm (SSA) to boost the BBN model performance. The performance of the BMLSSA-CAD algorithm can be studied using a benchmark dataset. The simulation outcomes highlighted that the BMLSSA-CAD method accomplishes improved security in the IIoT platform.
TSC-IBR: A Variant of Interval-Based MemoryReclamation Using CPU’s Time Stamp Counter
Authors: Zhang Chen , Yi Zhengming , Zhu Xinghui 
Published: October 2024

Abstract

To date, existing quiescent-state-based safe memory reclamation algorithms have relied on a global epoch counter maintained through software timestamps. While most quiescent-state-based approaches demonstrate good performance when employed in lock-free concurrent data structures, they grapple with issues concerning robustness. Specifically, in interval-based reclamation (IBR), a thread reclaiming a shared memory block must compare whether the lifetime of the block intersects with all threads’ reserved epoch intervals. IBR can provide more fine-grained memory reclamation management than epoch-based reclamation and hazard era. Here, we introduce the use of a hardware timestamp, which is obtained from the CPU’s Time Stamp Counter (TSC) register, a clock with cycle-level resolution. We propose a variant of IBR, named TSC-IBR, which leverages TSC instead of the software timestamp used in IBR. The value of TSC can be swiftly accessed without necessitating a system call. In our experiments, compared to other quiescent-state-based methods using the software timestamp, TSC-IBR exhibits excellent robustness across all lock-free concurrent data structure benchmarks, while also attaining high throughput in the vast majority of them.