bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Reality in the Surveillance of Breast Cancer Survivors—Results of a Patient Survey
Authors: Hans-Joachim Stemmler , Dorit Lässig , Petra Stieber , Ingo Bauerfeind , Steffen Kahlert , Alexander Fasching Peter , Wilhelm Beckmann Matthias , Margrit Glattes , Ursula Goldmann-Posch , Verena Hoffmann , Michael Untch , Volker Heinemann 
Published: December 2017

Background International guidelines for the surveillance of breast cancer patients recommend a minimized clinical follow-up including routine history and physical examination and regularly scheduled mammograms. However, the abandonment of scheduled follow-up examinations in breast cancer survivors remains a contradiction to established follow-up guidelines for other solid tumours. Patients and Methods We report the patients’ view on the basis of a survey performed in two separate geographical areas in Germany. The questionnaires were sent out to 2.658 patients with a history of breast cancer. Results A total of 801 patients (30.1%) responded to the questionnaire. The results of the survey can be summarized in two major categories: First, necessity for surveillance was affirmed by a majority (>95%), and 47.8% of the organized patients answered that there was a need for more intensive diagnostic effort during follow-up. The main expectation from an intensified follow-up was the increased feeling of security as expressed by >80% of the women. Second, the present survey indicates that most of the regularly scheduled follow-up visits were expanded using extensive laboratory and imaging procedures exceeding the quantity of examinations recommended in the present follow-up guidelines. Conclusion Despite the fact that only one third of the patients responded to the questionnaire, the survey indicates that a majority of physicians who treated these patients still do not accept the present follow-up guidelines. To some extent this may be explained by the observation that patients and possibly also their doctors trust that intensified follow-up increases diagnostic security and survival. Since considerable changes in the treatment options of breast cancer have been made during the last decades a new trial of investigations in follow-up is warranted.
The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice
Authors: Hattrup Christine L. , Bradley Judy M. , Kotlarczyk Kari L. , Madsen Cathy S. , Hentz Joseph G. , Marler Ronald J. , Gendler Sandra J. 
Published: December 2017

Background Though the importance of the transmembrane mucin MUC1 in mammary oncogenesis has long been recognized, the relative contributions of the cytoplasmic tail and tandem repeat domains are poorly understood. Methods To address this, mouse models of mammary carcinogenesis were created expressing full-length cytoplasmic tail-deleted, or tandem repeat-deleted MUC1 constructs. Results Overexpression of full-length MUC1 resulted in tumor formation in young mice (≤ 12 months); however, loss of either the cytoplasmic tail or the tandem repeat domain abrogated this oncogenic capacity. Aged mice in all strains developed late-onset mammary tumors similar to those previously described for the FVB background. Conclusions This study is the first spontaneous cancer model to address the relative importance of the cytoplasmic tail and tandem repeat domains to MUC1-driven mammary oncogenesis, and suggests that both of these domains are essential for tumor formation.
Circumareolar Mastopexy with Multiple Glandular Plications for Symmetry of the Contra-Lateral Breast, in Patients Undergoing Breast Reconstruction with Prosthesis. Experience on 50 Cases
Authors: Serra M. P. , Longhi P. , Robotti E. 
Published: December 2017

4 years experience on 50 cases using the Elliott's technique for symmetrization of the contra-lateral breast in patients undergoing breast reconstruction with an anatomical prosthesis is presented in this paper. The Elliott's technique with its double superior and horizontal plication is a suitable and long-lasting procedure for patients with small-moderate ptotic breast and elastic skin, who wish to have a simple procedure and an immediate result with minimal scars.
Murine pluripotent stem cells that escape differentiation inside teratomas maintain pluripotency
Authors: Pei Yangli , Yue Liang , Zhang Wei , Xiang Jinzhu , Ma Zhu , Han Jianyong 
Published: December 2017

Background. Pluripotent stem cells (PSCs) offer immense potential as a source for regenerative therapies. The teratoma assay is widely used in the field of stem cells and regenerative medicine, but the cell composition of teratoma is still elusive.
Methods. We utilized PSCs expressing enhanced green fluorescent protein (EGFP) under the control of the Pou5f1 promoter to study the persistence of potential pluripotent cells during teratoma formation in vivo. OCT4-MES (mouse embryonic stem cells) were isolated from the blastocysts of 3.5-day OCT4-EGFP mice (transgenic mice express EGFP cDNA under the control of the Pou5f1 promoter) embryos, and TG iPS 1-7 (induced pluripotent stem cells) were generated from mouse embryonic fibroblasts (MEFs) from 13.5-day OCT4-EGFP mice embryos by infecting them with a virus carrying OCT4, SOX2, KLF4 and c-MYC. These pluripotent cells were characterized according to their morphology and expression of pluripotency markers. Their differentiation ability was studied with in vivo teratoma formation assays. Further differences between pluripotent cells were examined by real-time quantitative PCR (qPCR).
Results. The results showed that s everal OCT4-expressing PSCs escaped differentiation inside of teratomas, and these escaped cells (MES-FT, GFP-positive cells separated from OCT4-MES-derived teratomas; and iPS-FT, GFP-positive cells obtained from teratomas formed by TG iPS 1-7) retained their pluripotency. Interestingly, a small number of GFP-positive cells in teratomas formed by MES-FT and iPS-FT ( MES-ST, GFP-positive cells isolated from MES-FT-derived teratomas; iPS-ST, GFP-positive cells obtained from teratomas formed by iPS-FT ) were still pluripotent, as shown by alkaline phosphatase (AP) staining, immunofluorescent staining and PCR. MES-FT, iPS-FT, MES-ST and iPS-ST cells also expressed several markers associated with germ cell formation, such as Dazl, Stella and Stra8.
Conclusions. In summary, a small number of PSCs escaped differentiation inside of teratomas , and these cells maintained pluripotency and partially developed towards germ cells. Both escaped PSCs and germ cells present a risk of tumor formation. Therefore, medical workers must be careful in preventing tumor formation when stem cells are used to treat specific diseases.
Transition From Collisional to Subduction‐Related Regimes: An Example From Neogene Panama‐Nazca‐South America Interactions
Authors: León Santiago , Cardona Agustín , Parra Mauricio , Sobel Edward R. , Jaramillo Juan S. , Glodny Johannes , Valencia Víctor A. , Chew David , Montes Camilo , Posada Gustavo , Monsalve Gaspar , Pardo‐Trujillo Andrés 
Published: December 2017

AbstractA geological transect across the suture separating northwestern South America from the Panama Arc helps document the provenance and thermal history of both crustal domains and the suture zone. During middle Miocene, strata were being accumulated over the suture zone between the Panama Arc and the continental margin. Integrated provenance analyses of those middle Miocene strata show the presence of mixed sources that includes material derived from the two major crustal domains: the old northwestern South American orogens and the younger Panama Arc. Coeval moderately rapid exhumation of Upper Cretaceous to Paleogene sediments forming the reference continental margin is suggested from our inverse thermal modeling. Strata within the suture zone are intruded by ~12 Ma magmatic arc‐related plutons, marking the transition from a collisional orogen to a subduction‐related one. Renewed late Miocene to Pliocene acceleration of the exhumation rates is the consequence of a second tectonic pulse, which is likely to be triggered by the onset of a flat‐slab subduction of the Nazca plate underneath the northernmost Andes of Colombia, suggesting that late Miocene to Pliocene orogeny in the Northern Andes is controlled by at least two different tectonic mechanisms.
Biometric Functions
Authors: Yang Grace L. 
Published: December 2017

AbstractBiometric functions are life‐table functions in their applications to studies in demography, epidemiology, actuarial science, and biomedical sciences.We focus on nonparametric estimation of two of the basic biometric functions, survival probability and life expectancy function, with censored or biased data. Invertible relations between any two of the hazard rate function, survival probability, and its cumulative hazard function reveal the product limit form for estimators of survival probability; the resulting estimator can be the Kaplan–Meier estimator for right‐censored data or the Lynden–Bell estimator for randomly truncated data. Presenting censoring and biased sampling models in a unifying view, some of the results on nonparametric estimators of the survival probability and life expectancy function are highlighted. Generalizations from the basic right censoring model to multiple decrement model to multistate competing risk models are noted. An illustrative example of constructing a length‐biased model for population studies is given, which helps to compare with other available length‐biased models.
Dynamic Treatment Regimes
Authors: Moodie Erica E. M. , Stephens David A. 
Published: December 2017

AbstractDynamic treatment regimes describe a class of treatments or interventions, often given sequentially, that are tailored to the characteristics of an individual at the time the treatment decision is made. In this article, we introduce dynamic treatment regimes and sequential multiple assignment randomized trial designs, which give rise to the data that can be used to estimate the impact of such personalized treatment strategies.
Ramanathan (Ram)Gnanadesikan
Authors: Kettenring Jon R. , Landwehr James M. , Strawderman William E. 
Published: December 2017

AbstractRam Gnanadesikan was one of the foremost industrial statisticians of the twentieth century. After completing his PhD at the University of North Carolina, he spent 2 years at Procter & Gamble before joining Bell Labs in 1959, where he rose to be the head of the statistics and data analysis research department. (Bell Labs was the research and development arm of the nationwide Bell System in the United States before its breakup in 1984.) At the breakup Ram joined Bellcore as division manager of information sciences research. In 1986, he was promoted to assistant vice president of information sciences and technologies research. In 1991, He joined the Rutgers University department of statistics as a professor, where he remained until his retirement in 1998. The goal of this article is to highlight some of Ram's many accomplishments during his career as a leader, researcher, and educator.
Multiscale Phase Separations for Hierarchically Ordered Macro/Mesostructured Metal Oxides
Authors: Jo Changshin , Hwang Jongkook , Lim Won‐Gwang , Lim Jun , Hur Kahyun , Lee Jinwoo 
Published: December 2017

AbstractPorous architectures play an important role in various applications of inorganic materials. Several attempts to develop mesoporous materials with controlled macrostructures have been reported, but they usually require complicated multiple‐step procedures, which limits their versatility and suitability for mass production. Here, a simple approach for controlling the macrostructures of mesoporous materials, without templates for the macropores, is reported. The controlled solvent evaporation induces both macrophase separation via spinodal decomposition and mesophase separation via block copolymer self‐assembly, leading to the formation of hierarchically porous metal oxides with periodic macro/mesostructures. In addition, using this method, macrostructures of mesoporous metal oxides are controlled into spheres and mesoporous powders containing isolated macropores. Nanocomputed tomography, focused ion beam milling, and electron microscopy confirm well‐defined macrostructures containing mesopores. Among the various porous structures, hierarchically macro/mesoporous metal oxide is employed as an anode material in lithium‐ion batteries. The present approach could provide a broad and easily accessible platform for the manufacturing of mesoporous inorganic materials with different macrostructures.
An Unfused‐Core‐Based Nonfullerene Acceptor Enables High‐Efficiency Organic Solar Cells with Excellent Morphological Stability at High Temperatures
Authors: Li Shuixing , Zhan Lingling , Liu Feng , Ren Jie , Shi Minmin , Li Chang‐Zhi , Russell Thomas P. , Chen Hongzheng 
Published: December 2017

AbstractMost nonfullerene acceptors developed so far for high‐performance organic solar cells (OSCs) are designed in planar molecular geometry containing a fused‐ring core. In this work, a new nonfullerene acceptor of DF‐PCIC is synthesized with an unfused‐ring core containing two cyclopentadithiophene (CPDT) moieties and one 2,5‐difluorobenzene (DFB) group. A nearly planar geometry is realized through the F···H noncovalent interaction between CPDT and DFB for DF‐PCIC. After proper optimizations, the OSCs with DF‐PCIC as the acceptor and the polymer PBDB‐T as the donor yield the best power conversion efficiency (PCE) of 10.14% with a high fill factor of 0.72. To the best of our knowledge, this efficiency is among the highest values for the OSCs with nonfullerene acceptors owning unfused‐ring cores. Furthermore, no obvious morphological changes are observed for the thermally treated PBDB‐T:DF‐PCIC blended films, and the relevant devices can keep ≈70% of the original PCEs upon thermal treatment at 180 °C for 12 h. This tolerance of such a high temperature for so long time is rarely reported for fullerene‐free OSCs, which might be due to the unique unfused‐ring core of DF‐PCIC. Therefore, the work provides new idea for the design of new nonfullerene acceptors applicable in commercial OSCs in the future.
Perovskite Quantum Dots with Near Unity Solution and Neat‐Film Photoluminescent Quantum Yield by Novel Spray Synthesis
Authors: Dai Shu‐Wen , Hsu Bo‐Wei , Chen Chien‐Yu , Lee Chia‐An , Liu Hsiao‐Yun , Wang Hsiao‐Fang , Huang Yu‐Ching , Wu Tien‐Lin , Manikandan Arumugam , Ho Rong‐Ming , Tsao Cheng‐Si , Cheng Chien‐Hong , Chueh Yu‐Lun , Lin Hao‐Wu 
Published: December 2017

AbstractIn this study, a novel perovskite quantum dot (QD) spray‐synthesis method is developed by combining traditional perovskite QD synthesis with the technique of spray pyrolysis. By utilizing this new technique, the synthesis of cubic‐shaped perovskite QDs with a homogeneous size of 14 nm is demonstrated, which shows an unprecedented stable absolute photoluminescence quantum yield ≈100% in the solution and even in the solid‐state neat film. The highly emissive thin films are integrated with light emission devices (LEDs) and organic light emission displays (OLEDs). The color conversion type QD‐LED (ccQD‐LED) hybrid devices exhibit an extremely saturated green emission, excellent external quantum efficiency of 28.1%, power efficiency of 121 lm W−1, and extraordinary forward‐direction luminescence of 8 500 000 cd m−2. The conceptual ccQD‐OLED hybrid display also successfully demonstrates high‐definition still images and moving pictures with a 119% National Television System Committee 1931 color gamut and 123% Digital Cinema Initiatives‐P3 color gamut. These very‐stable, ultra‐bright perovskite QDs have the properties necessary for a variety of useful applications in optoelectronics.
Carbohydrate‐Responsive Surface Adhesion Based on the Dynamic Covalent Chemistry of Phenylboronic Acid‐ and Catechol‐Containing Polymer Brushes
Authors: Lamping Sebastian , Otremba Tobias , Ravoo Bart Jan 
Published: December 2017

AbstractA glue, based on dynamic covalent chemistry, with a strong adhesion (2.38 kg cm−2), water resistance and carbohydrate responsive reversibility is presented. Using surface initiated atom transfer radical polymerization (SI‐ATRP), glass and silicon surfaces were coated with copolymers functionalized with phenylboronic acids and catechols. In combination with microcontact printing (μCP) these polymer brushes give access to a carbohydrate responsive “supramolecular Velcro”.
Solution electrospinning with a pulsed electric field
Authors: Li Kaili , Wang Ying , Xie Gai , Kang Jingxin , He Hong , Wang Kejian , Liu Yong 
Published: December 2017

ABSTRACTGetting finer fibers is one important goal of electrospinning. In this article, we introduce orthogonal experimental research of solution electrospinning with a pulsed electric field. The influences of the voltage, flow rate, frequency, and duty cycle on the mean diameter and diameter distribution of electrospun fibers were investigated. The phenomenon of electrospinning in a pulsed electric field was compared to that of electrospinning in an ordinary electric field. We found that the order of the factors that affected the fiber diameter was Duty cycle > Flow rate > Voltage > Frequency and the order of factors that affected the fiber diameter distribution was Duty cycle > Flow rate > Frequency > Voltage. In addition, compared with the ordinary electric field, the pulsed electric field apparently contributed to reductions in the mean fiber diameter and diameter distribution. In this article, we provide important evidence for the reduction of the fiber diameter with the pulsed electric field. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46130.
Trends and clinicopathological predictors of axillary evaluation in ductal carcinoma in situ patients treated with breast‐conserving therapy
Authors: Huang Nai‐si , Si Jing , Yang Ben‐long , Quan Chen‐lian , Chen Jia‐jian , Wu Jiong 
Published: December 2017

AbstractThe aim of this study was to investigate the trends of axillary lymph node evaluation in ductal carcinoma in situ (DCIS) patients treated with breast‐conserving therapy (BCT) and to identify the clinicopathological predictors of axillary evaluation. DCIS patients treated with BCT in 2006–2015 at our institute were retrospectively included in the analysis. Patients were categorized into three groups: sentinel lymph node biopsy (SLNB), axillary lymph node dissection (ALND), and non‐evaluation. Univariate and multivariate logistic regression analyses were performed to identify factors that predicted axillary evaluation. A total of 315 patients were identified, among whom 135 underwent SLNB, and 15 underwent ALND. The proportion of patients who underwent axillary evaluation increased from 33.0% in 2006–2010 to 53.8% in 2011–2015 (P < 0.001), however, no patients had lymph node metastasis based on final pathology. In multivariate analysis, high‐grade tumor favored axillary evaluation (OR = 4.376, 95% CI:1.410–13.586, P = 0.011); while excision biopsy favored no axillary evaluation compared with other biopsy methods (OR = 0.418, 95% CI: 0.192–0.909, P = 0.028). Subgroup analysis of patients treated in 2011–2015 revealed that high‐grade tumor (OR = 5.898, 95% CI: 1.626–21.390, P = 0.007) and palpable breast lump (OR = 2.497, 95% CI: 1.037–6.011, P = 0.041) were independent predictors of axillary lymph node evaluation. Despite the significant decrease in ALND and a concerning overuse of SLNB, we identified no axillary lymph node metastasis, which justified omitting axillary evaluation in these patients. High‐grade tumor, palpable lump, and biopsy method were independent predictors of axillary evaluations. Excision biopsy of suspicious DCIS lesions may potentially preclude the invasive component of the disease and help to avoid axillary surgery
Incidence and risk factors of postoperative pneumonia following cancer surgery in adult patients with selected solid cancer: results of “Cancer POP” study
Authors: Jung Jiwon , Moon Song Mi , Jang Hee‐Chang , Kang Cheol‐In , Jun Jae‐Bum , Cho Yong Kyun , Kang Seung‐Ji , Seo Bo‐Jeong , Kim Young‐Joo , Park Seong‐Beom , Lee Juneyoung , Yu Chang Sik , Kim Sung‐Han 
Published: December 2017

AbstractThe aim of this study was to investigate the incidence and risk factors of postoperative pneumonia (POP) within 1 year after cancer surgery in patients with the five most common cancers (gastric, colorectal, lung, breast cancer, and hepatocellular carcinoma [HCC]) in South Korea. This was a multicenter and retrospective cohort study performed at five nationwide cancer centers. The number of cancer patients in each center was allocated by the proportion of cancer surgery. Adult patients were randomly selected according to the allocated number, among those who underwent cancer surgery from January to December 2014 within 6 months after diagnosis of cancer. One‐year cumulative incidence of POP was estimated using Kaplan–Meier analysis. An univariable Cox's proportional hazard regression analysis was performed to identify risk factors for POP development. As a multivariable analysis, confounders were adjusted using multiple Cox's PH regression model. Among the total 2000 patients, the numbers of patients with gastric cancer, colorectal cancer, lung cancer, breast cancer, and HCC were 497 (25%), 525 (26%), 277 (14%), 552 (28%), and 149 (7%), respectively. Overall, the 1‐year cumulative incidence of POP was 2.0% (95% CI, 1.4–2.6). The 1‐year cumulative incidences in each cancer were as follows: lung 8.0%, gastric 1.8%, colorectal 1.0%, HCC 0.7%, and breast 0.4%. In multivariable analysis, older age, higher Charlson comorbidity index (CCI) score, ulcer disease, history of pneumonia, and smoking were related with POP development. In conclusions, the 1‐year cumulative incidence of POP in the five most common cancers was 2%. Older age, higher CCI scores, smoker, ulcer disease, and previous pneumonia history increased the risk of POP development in cancer patients.
The delta opioid peptide D‐Alanine 2, Leucine 5 Enkephaline (DADLE)‐induces neuroprotection through cross‐talk between the UPR and pro‐survival MAPK‐NGF‐Bcl2 signaling pathways via modulation of several micro‐RNAs in SH‐SY5Y cells subjected to ER stress
Authors: Moghal Erfath Thanjeem Begum , Venkatesh Katari , Sen Dwaipayan 
Published: December 2017

AbstractParkinson's disease (PD) is the second most progressive neurodegenerative disease characterized by the loss of dopaminergic neurons and accumulation of misfolded proteins in endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR). In the present study, we aimed to determine the potential survival effect of the delta opioid neuro‐peptide D‐Alanine 2, Leucine 5 Enkephaline (DADLE), and its mechanism in dopaminergic SH‐SY5Y cells which were subjected to ER stress. In this cellular model of PD, enhanced cell survivability was observed on DADLE treatment (but not with μ and κ opioid agonists) along with concomitant down regulation of the UPR stress sensors and protein aggregates. The study found increased phosphorylation of MEK‐1, which leads to activation of MAP kinase as well as enhanced expression of the pro‐survival gene nerve growth factor and anti‐apoptotic marker Bcl2. DADLE treatment could also significantly inhibit expression of the pro‐apoptotic marker BIM. Next‐generation sequence analysis revealed 93 micro (mi) RNAs to be differentially regulated following DADLE treatment in cells subjected to ER stress. Pathway prediction and previously published reports revealed that out of these 93 miRNAs, 34 can play a role in promoting cell survival. Specific modulation of two such miRNAs, namely miR‐30c‐2‐3p and miR‐200c, could partially reverse the positive survival effect induced by DADLE. Apart from the known miRNAs, various novel miRNAs were also observed following DADLE treatment which could also play a role in enhancing the survival of SH‐SY5Y cells under ER stress.