bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-tumor activity of cabozantinib by FAK down-regulation in human oral squamous cell carcinoma
Authors: Li Da-Lu , Wei Zhu-Liang , Zhang Wen-Mei , Li Zhi-Gang 
Published: December 2015

<p class="Abstract">Cabozantinib is a tyrosine kinase inhibitor involved in inhibition of cell proliferation and colony formation. We studied anti-cancer properties of cabozantinib in oral squamous cell carcinoma cells. The viability of BHY and HSC-3 cells decreased with increase in cabozantinib concentration and time. The proliferation of cell lines was affected by increasing concentration of cabozantinib from 0.3 to 1.2 μM after 48 hours of treatment. The expression of MET and phosphorylated MET was not affected by cabozantinib treatment. Cabozantinib-treated cells when compared to control, showed concentration-dependent increase in BHY and HSC-3 cells during G2/M phase and decrease in S phase with increase in cabozantinib concentration. Annexin-V/propidium iodide double staining showed that cells with annexin-V increased with the increase in cabozantinib concentration. The expression of apoptosis related proteins cleaved caspase-3 and cleaved-PARP were increased with increase in cabozantinib concentration. It was also found that suppression of FAK activation and expression was dose dependent. The results from this study revealed that cabozantinib can be useful in developing a drug for effective treatment of oral squamous cell carcinoma cells.</p><p> </p>
GRASPING THE NATURE OF POTENTIALLY HAZARDOUS ASTEROIDS
Authors: Perna D. , Dotto E. , Ieva S. , Barucci M. A. , Bernardi F. , Fornasier S. , Luise F. De , Perozzi E. , Rossi A. , Epifani E. Mazzotta , Micheli M. , Deshapriya J. D. P. 
Published: December 2015

ABSTRACT
Through their delivery of water and organics, near-Earth objects (NEOs) played an important role in the emergence of life on our planet. However, they also pose a hazard to the Earth, as asteroid impacts could significantly affect our civilization. Potentially hazardous asteroids (PHAs) are those that, in principle, could possibly impact the Earth within the next century, producing major damage. About 1600 PHAs are currently known, from an estimated population of 4700 ± 1450. However, a comprehensive characterization of the PHA physical properties is still missing. Here we present spectroscopic observations of 14 PHAs, which we have used to derive their taxonomy, meteorite analogs, and mineralogy. Combining our results with the literature, we investigated how PHAs are distributed as a function of their dynamical and physical properties. In general, the “carbonaceous” PHAs seem to be particularly threatening, because of their high porosity (limiting the effectiveness of the main deflection techniques that could be used in space) and low inclination and minimum orbit intersection distance (MOID) with the Earth (favoring more frequent close approaches). V-type PHAs also present low MOID values, which can produce frequent close approaches (as confirmed by the recent discovery of a limited space weathering on their surfaces). We also identified those specific objects that deserve particular attention because of their extreme rotational properties, internal strength, or possible cometary nature. For PHAs and NEOs in general, we identified a possible anti-correlation between the elongation and the rotational period, in the range of P
rot ≈ 5–80 hr. This would be compatible with the behavior of gravity-dominated aggregates in rotational equilibrium. For periods ≳80–90 hr, such a trend stops, possibly under the influence of the YORP effect and collisions. However, the statistics is very low, and further observational and theoretical work is required to characterize such slow rotators.
DIRECT DETECTION OF THE L-DWARF DONOR IN WZ SAGITTAE
Authors: Harrison Thomas E. 
Published: December 2015

ABSTRACT
Analysis of a large set of phase-resolved K-band spectra of the cataclysmic variable WZ Sge shows that the secondary star of this system appears to be an L-dwarf. Previous K-band spectra of WZ Sge found that the CO overtone bandheads were in emission. We show that absorption from the 12CO(2,0) bandhead of the donor star creates a dip in the 12CO(2,0) emission feature. Measuring the motion of this feature over the orbital period, we construct a radial velocity curve that gives a velocity amplitude of K
abs = 520 ± 35 km s−1, consistent with the previously published values for this parameter.
UPPER LIMIT OF THE VISCOSITY PARAMETER IN ACCRETION FLOWS AROUND A BLACK HOLE WITH SHOCK WAVES
Authors: Nagarkoti Shreeram , Chakrabarti Sandip K. 
Published: December 2015

ABSTRACT
Black hole accretion is necessarily transonic; thus, flows must become supersonic and, therefore, sub-Keplerian before they enter into the black hole. The viscous timescale is much longer than the infall timescale close to a black hole. Hence, the angular momentum remains almost constant and the centrifugal force

becomes increasingly dominant over the gravitational force

The slowed down matter piles creating an accretion shock. The flow between shock and inner sonic point is puffed up and behaves like a boundary layer. This so-called Comptonizing cloud/corona produces hard X-rays and jets/outflows and, therefore, is an important component of black hole astrophysics. In this paper, we study steady state viscous, axisymmetric, transonic accretion flows around a Schwarzschild black hole. We adopt a viscosity parameter α and compute the highest possible value of α (namely,

) for each pair of two inner boundary parameters (namely, specific angular momentum carried to horizon, l
in and specific energy at inner sonic point,

) which is still capable of producing a standing or oscillating shock. We find that while such possibilities exist for α as high as

in very small regions of the flow parameter space, typical

appears to be about ∼0.05–0.1. Coincidentally, this also happens to be the typical viscosity parameter achieved by simulations of magnetorotational instabilities in accretion flows. We therefore believe that all realistic accretion flows are likely to have centrifugal pressure supported shocks unless the viscosity parameter everywhere is higher than
THE STAR CLUSTER MASS–GALACTOCENTRIC RADIUS RELATION: IMPLICATIONS FOR CLUSTER FORMATION
Authors: Sun Weijia , Grijs Richard de , Fan Zhou , Cameron Ewan 
Published: December 2015

ABSTRACT
Whether or not the initial star cluster mass function is established through a universal, galactocentric-distance-independent stochastic process, on the scales of individual galaxies, remains an unsolved problem. This debate has recently gained new impetus through the publication of a study that concluded that the maximum cluster mass in a given population is not solely determined by size-of-sample effects. Here, we revisit the evidence in favor and against stochastic cluster formation by examining the young (

a few

year old) star cluster mass–galactocentric radius relation in M33, M51, M83, and the Large Magellanic Cloud. To eliminate size-of-sample effects, we first adopt radial bin sizes containing constant numbers of clusters, which we use to quantify the radial distribution of the first- to fifth-ranked most massive clusters using ordinary least-squares fitting. We supplement this analysis with an application of quantile regression, a binless approach to rank-based regression taking an absolute-value-distance penalty. Both methods yield, within the

to

uncertainties, near-zero slopes in the diagnostic plane, largely irrespective of the maximum age or minimum mass imposed on our sample selection, or of the radial bin size adopted. We conclude that, at least in our four well-studied sample galaxies, star cluster formation does not necessarily require an environment-dependent cluster formation scenario, which thus supports the notion of stochastic star cluster formation as the dominant star cluster-formation process within a given galaxy.
Coexistence of P190 BCR/ABL transcript and CALR 52-bp deletion in chronic myeloid leukemia blast crisis: a case report
Authors: Saki Najmaldin , Seghatoleslami Mohammad , Ketabchi Neda , Ordo Alireza , Mohammadi-Asl Javad , Golchin Neda 
Published: December 2015

We present a case of a 78-year-old woman presented with thrombocytosis and high blast count, who had a history of splenectomy. Her cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XX karyotype with t(9;22)(q34;q11). RT-PCR assay detected the e1a2 BCR-ABL translocation resulting from a rearrangement of the minor breakpoint cluster region (m-bcr) in the BCR gene. Subsequent evaluations of the disease showed calreticulin (CALR) 52-bp deletion as well as the absence of JAK2V617F heterozygous mutation in granulocyte population of peripheral blood using allele-specific PCR and bi-directional DNA sequencing. To our knowledge, this is the first case of a patient initially diagnosed as p190 BCR-ABL transcript positive CML in blastic crisis characterized with a 52-bp deletion in CALR gene.
An Inverse Source Problem with Sparsity Constraint for the Time-Fractional Diffusion Equation
Authors: Ruan Zhousheng , Yang Zhijian , Lu Xiliang 
Published: December 2015

AbstractIn this paper, an inverse source problem for the time-fractional diffusion equation is investigated. The observational data is on the final time and the source term is assumed to be temporally independent and with a sparse structure. Here the sparsity is understood with respect to the pixel basis, i.e., the source has a small support. By an elastic-net regularization method, this inverse source problem is formulated into an optimization problem and a semismooth Newton (SSN) algorithm is developed to solve it. A discretization strategy is applied in the numerical realization. Several one and two dimensional numerical examples illustrate the efficiency of the proposed method.
Forms, function, and use of Early Eneolithic pottery and settlement structures from ZgornjeRadvanje, Slovenia
Authors: Kramberger Bine 
Published: December 2015

This paper discusses the use of ceramic objects in daily life in the Early Eneolithic period, based on ceramic assemblages from the settlement at Zgornje Radvanje in Maribor. The possible function of individual pottery types was studied through typological analysis, pottery production methods, traces of secondary burning and carbonized residues, and ethnographic parallels. The function of different types of settlement structure is discussed on the basis of statistical comparisons of the composition of ceramic assemblages.
Archaeological culture, please meet yoghurt culture: towards a relational archaeology of milk
Authors: Mlekuž Dimitrij 
Published: December 2015

Taking milk as a point of departure, we set out on a journey to explore the ‘mutual becomings’ of different bodies, species, and things. We argue that milk should be understood as a component in an assemblage that connects animals, humans, hormones, enzymes, bacteria, food, genes, technologies and material culture. These complex entanglements produced new, unexpected results and effects. Since they form part of this assemblage, all its components are profoundly changed. Focusing on this diversity of relations between humans, other creatures, things and substances is a key to an archaeology that does not radically separate humans and nonhumans.
Analysis of late mid-Neolithic pottery illuminates the presenceof a Corded Ware Culture on the Baltic Island of Gotland
Authors: Palmgren Erik , Martinsson Wallin Helene 
Published: December 2015

In this paper, we discuss variations seen in the ornamentation and modes of manufacturing pottery from the end of the mid-Neolithic 4600–4300 BP on the Island of Gotland in the Baltic Sea. The Pitted Ware cultural groups have been discussed as a western influence from the Swedish mainland, but the aDNA on skeletal remains point to eastern influences. We analyse and discuss pottery from the well-investigated Ajvide Pitted Ware site and what these variations mean in term of intra- and inter-island relationships, ethnicity and change, and we suggest the development of what could be described as a hybrid culture.
New Neolithic cult centres and domestic settlements in the light of Urfa Region Surveys
Authors: Celik Bahattin 
Published: December 2015

The present study concerns Neolithic period cult centres and settlements discovered recently during surface surveys in the central district of Urfa (Sanlıurfa) region in south-eastern Turkey. The presence of T-shaped pillars was ascertained at Ayanlar Höyük and Kurt Tepesi cult sites. Other settlements are domestic settlements arranged around cult centre settlements. Some sites belong to Pre Pottery Neolithic, and the others to Pottery Neolithic. They are believed to be coeval with Göbekli Tepe and Nevali Çori cult sites.
The 8200 calBP climate event and the spread of the Neolithic in Eastern Europe
Authors: Kulkova Marianna Alexeevna , Mazurkevich Andrey N. , Dolbunova Ekaterina V. , Lozovsky Vladimir M. 
Published: December 2015

At 8200 calBP, the beginning of the Atlantic period, there was a drastic change from warm and humid climatic conditions to cold conditions. The abrupt cooling at 8200 calBP has been documented in different parts of Europe. In western, and some parts of southern, Europe, this event was a trigger for new forms of economy and migrations of groups of Neolithic farmers. This paper considers the different ways in which ceramic traditions developed in eastern Europe in the steppe,steppe-forest and forest zones as a result of the rapid climate changes at about 8200 calBP.
Cultural and demic diffusion of first farmers, herders,and their innovations across Eurasia
Authors: Lemmen Carsten 
Published: December 2015

Was the spread of agro-pastoralism from the Eurasian founder regions dominated by demic or by cultural diffusion? This study employs simulations that unfold a complex inter-regional and time varying pattern of demic and diffusive exchange processes during the Neolithisation, and thus supports from a modelling perspective the hypothesis that there is no simple or exclusive demic or cultural diffusion, but that in most regions of Eurasia a combination of demic and cultural processes were important.
In and out of sync: ritmos de tradução em performance e dança
Authors: Brandstetter Gabriele , Hilgert Tradução de: Mariana Cristine , Zea Evelyn Schuler 
Published: December 2015

http://dx.doi.org/10.5007/2175-7968.2015v35n2p388Este artigo focaliza questões relativas a sincronização de movimentos; coreografia e performance, bem como a técnicas corporais que abordam temáticas de integração e perturbação (dessincronização, “Out of Sync”). Partindo de questões políticas e sociais da atualidade, levantadas pela transposição de fronteiras e por movimentos migratórios, o presente artigo relaciona o tema das “sincronizações” a reflexões sobre tradução e entrelaçamentos de culturas de movimento “a serem traduzidos”. Situações de dentro e fora de sincronia, “In and Out of Sync”, bem como dinâmicas e ritmos de movimento, expostos ao final como um “rite de passage” entre vida e morte, são apresentados a partir de exemplos de diferentes performances de dança, nas quais formas divergentes de conhecimento corporal se sincronizam com técnicas de movimento. À luz da instalação “Orfeu” (2015), de Susanne Kennedy, coloca-se em discussão a relevância da zona liminar do “entre”, “In between” e da intrusão (com base na teoria de Jean Luc Nancy sobre o intruso, “L’Intrus”) no que diz respeito à dessincronização.
The Impact of the Economic Downturn in the Spanish Civil Justice System
Authors: Carballo Piñeiro Laura , Nieva Fenoll Jordi 
Published: December 2015

The Impact of the Economic Downturn in the Spanish Civil Justice System
The Spanish justice system has been shaken by the economic downturn as many other institutions have. This article addresses in the first place some statistical data that shed light as regards to the number of judges and the costs and length of the procedure in Spain. These figures help to understand, in the second place, the impact of austerity measures on the judiciary, namely, the freeze on the hiring of judges and the establishing of high court fees. While they mainly concern the supply side of justice services, others such cost reductions in legal aid have had, in the third place, an impact on the demand side, driving many citizens to social exclusion and to resorting to self-defence mechanisms. The final part of this article addresses some remedies that may alleviate judiciary’s workload, but that fall short of doing it. All in all, the Spanish justice system seems to require a holistic approach to patch up edges, but one in which the role of judge-made justice in a democratic society has to be central again.
Shoarma aan de rol!
Authors: van Rooij-van den Bos Linda , Verdonk-Kleinjan Wendy , Jansen Laurie , Jansen Herman , Mittendorff Ghislaine 
Published: December 2015

Shoarma aan de rol! Het effect van vernieuwend toezicht
In 2011 blijkt dat 60% van de shoarmaondernemers de voedselveiligheidswetgeving naleeft. Dit naleefniveau is voor de NVWA onvoldoende en er wordt vastgesteld dat de reguliere werkwijze onvoldoende effect heeft op de doelgroep. Een gestructureerde aanpak van het probleem, via risico- en doelgroepanalyse, leidt tot een andere, meer overwogen en op de doelgroep afgestemde interventie, die nog effectief blijkt ook. Voor andere toezichthouders kan deze casus gebruikt worden als een ‘best practice’ om op een andere wijze het toezicht in te richten.
Bespreking proefschrift van Melissa van den Broek, Preventing money laundering – A legal study on the effectiveness of supervision in the European Union, Den Haag: Boom Juridische uitgevers 2015
Authors: Bökkerink Maud 
Published: December 2015

Bespreking proefschrift van Melissa van den Broek, Preventing money laundering – A legal study on the effectiveness of supervision in the European Union, Den Haag: Boom Juridische uitgevers 2015
In haar proefschrift heeft Melissa van den Broek een juridisch onderzoek gedaan naar de effectiviteit van het antiwitwastoezicht in Nederland, Zweden, Spanje en het Verenigd Koninkrijk. Daar waar Van den Broek Spanje als minst effectieve toezichtsysteem van deze vier landen beoordeelt, heeft de Financial Action Task Force (FATF) de effectiviteit van het toezicht door Spanje als goed (‘substantial’) beoordeeld. Het verschil lijkt er met name in te liggen dat de FATF de kennis van de Spaanse toezichthouder over de witwasrisico’s bij de onder toezicht staande instellingen en in de sectoren als belangrijk positief punt heeft meegewogen, terwijl Van den Broek meer in algemene zin naar kennis over instellingen kijkt.
Preparation of [C60]Fullerene Nanowhisker-gold Nanoparticle Composites and Reduction of 4-Nitrophenol through Catalysis
Authors: Ko Jeong Won , Li Jiulong , Ko Weon Bae 
Published: December 2015

A gold nanoparticle solution was prepared by adding sodium borohydride (NaBH4), trisodium citrate dihydrate (C6H5Na3O7·2H2O), cetyltrimethyl ammonium bromide (CTAB,(C16H33)N(CH3)3Br), ascorbic acid (C6H8O6), and potassium tetrachloroaurate(III)(KAuCl4) to distilled water and stirring the solution for 15 min. [C60]fullerene nanowhisker-gold nanoparticle composites were synthesized using C60-saturated toluene, the gold nanoparticle solution, and isopropyl alcohol by liquid-liquid interfacial precipitation (LLIP). The product of the nanocomposites was characterized by X-ray diffraction, scanning electron microscopy, Raman spectroscopy, transmission electron microscopy, and solid-state 13C-nuclear magnetic resonance spectroscopy. The catalytic activity of the [C60]fullerene nanowhisker-gold nanoparticle composites was confirmed in 4-nitrophenol reduction by UV-vis spectroscopy.
Stratégies d’artification dans le domaine du luxe. Le cas des vins de prestige
Authors: Passebois-Ducros Juliette , Trinquecoste Jean-François , Pichon Frédéric 
Published: December 2015

Cet article étudie certaines pratiques d’artification, c’est-à-dire de transformation du « non art » en « art » appliquées au secteur du luxe et plus particulièrement aux produits de luxe issus du terroir : les vins de prestige. Après avoir exposé la tendance actuelle des grandes « maisons » de luxe à se rapprocher du monde de l’art et de la culture, nous interrogeons cette tendance au regard du concept d’artification développé par Shapiro (2004). L’analyse confirme que le secteur du luxe suit aujourd’hui une artification partielle qui facilite la perception des produits de luxe comme des produits uniques, proches des œuvres d’art. Le cas particulier des vins de luxe est ensuite étudié à dessein de comprendre les modalités spécifiques des pratiques d’artification dans un domaine où les produits sont issus de la terre et donc de la Nature beaucoup plus que de la Culture. Une analyse des communications effectuée au travers du carré sémiotique met au jour les stratégies sous-jacentes à cet objectif d’artification des vins de luxe. Nous analysons les risques et avantages de telles stratégies ainsi que les conditions d’efficience de nouveaux codes communicationnels fondés sur la « signature ».
A implantação do currículo baseado em competência na graduação de fisioterapia: a integralidade como eixo condutor
Authors: Raymundo Camila Sotello , Varjabedian Deborah , Guazzelli Maria Elisabete , Akerman Marco 
Published: December 2015

Introdução: Na busca de um novo perfil para o fisioterapeuta, há a necessidade de reformular a formação de profissionais fisioterapeutas que atendam a uma nova demanda. Este estudo busca apoiar‑se nas premissas da interdisciplinaridade na organização dos conhecimentos e o desenvolvimento de práticas e ações que buscam a integralidade na atenção a saúde entre os docentes do curso de graduação de fisioterapia de uma Universidade Privada e Internacional aqui estudada, por meio de um currículo baseado em competências. Objetivo: Identificar as dificuldades e as facilidades da implantação de um currículo por competências no curso de Fisioterapia, orientado pela Integralidade. Métodos: Neste percurso, utilizamos como método a Pesquisa‑Ação, como estratégia para a investigação da eficácia da implantação do currículo integrado e os atores envolvidos foi o corpo docente. Resultados: Durante o processo de implantação do currículo foi possível entender que um currículo baseado por competências é flexível, permite mudanças, de acordo com as necessidades atuais. Conclusão: Conclui‑se que um currículo integrado permite sempre novas inserções, com possibilidade de ouvir e empoderar os docentes neste processo, que são essenciais para o sucesso na implantação de um currículo baseado em cometências.
Extensão Universitária na Faculdade de Medicina do ABC: quais avanços e limites?
Authors: Conchão Silmara 
Published: December 2015

Introdução: É no interior do nosso contexto, no que se refere ao aprimoramento do ensino, assistência e pesquisa, apresentaremosa COMEX, a Comissão de Extensão da Faculdade de Medicina do ABC da Fundação do ABC, localizada na cidade de Santo André, região metropolitana de São Paulo, Brasil. Um relato sobre os avanços e limites de seis anos de vivência em extensão acadêmica junto a um grupo de professores(as) e alunos(as) das diversas áreas das ciências da saúde. Relato de Experiência: Desenvolvemos ações em diferentes cenários, uma intensa agenda pautada por fazer, acolher, buscar, resolver, avaliar, planejar e replanejar, investigar, ouvir, observar, comunicar e criar. Atuar em equipe com o esperado, mas também com o improviso, tirar os olhos das redes sociais e ver o entorno. Conclusão: Um processo que tem possibilitado decisões e mudanças, ressignificado a nossa existência, visão de mundo e os nossos sentidos. Aprendemos que o ensino e a pesquisa avançam muito quando estão associados com a efetiva interação da universidade com a realidade social.