bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide analysis of banana MADS-box family closely related to fruit development and ripening
Authors: Liu Juhua , Zhang Jing , Zhang Jianbin , Miao Hongxia , Wang Jingyi , Gao Pengzhao , Hu Wei , Jia Caihong , Wang Zhuo , Xu Biyu , Jin Zhiqiang 
Published: June 2017

AbstractProteins encoded by MADS-box genes are important transcription factors involved in the regulation of flowering plant growth and development. Currently, no systematic information exists regarding the MADS-box family in the important tropical fruit banana. Ninety-six MADS-box genes were identified from the banana (Pahang) A genome. Phylogenetic analysis indicated that Musa acuminata MCM1-AGAMOUS- DEFICIENS-SRF (MaMADS) could be divided into MIKCc, MIKC*, Mα/β and Mγ groups. MIKCc could be further divided into 11 subfamilies, which was further supported by conserved motif and gene structure analyses. Transcriptome analysis on the Feng Jiao (FJ) and BaXi Jiao (BX) banana cultivars revealed that MaMADS genes are differentially expressed in various organs, at different fruit development and ripening stages, indicating the involvement of these genes in fruit development and ripening processes. Interactive network analysis indicated that MaMADS24 and 49 not only interacted with MaMADS proteins themselves, but also interacted with hormone-response proteins, ethylene signal transduction and biosynthesis-related proteins, starch biosynthesis proteins and metabolism-related proteins. This systematic analysis identified candidate MaMADS genes related to fruit development and ripening for further functional characterization in plants, and also provided new insights into the transcriptional regulation of MaMADS genes, facilitating the future genetic manipulation of MADS-mediated fruit development and ripening.
Assessing the Believability of Standardized Patients Trained to Portray Communication Disorders
Authors: Baylor Carolyn , Burns Michael I. , Struijk Jennie , Herron Lindsay , Mach Helen , Yorkston Kathryn 
Published: June 2017

Purpose
The purpose of this study was to evaluate the believability of standardized patients portraying individuals with communication disorders as part of a larger study in which standardized patients help train medical and allied health students about communication disorders.

Method
Two women portrayed persons with aphasia, and 2 men depicted persons with dysarthria associated with Parkinson's disease. Two stakeholder groups rated believability. Speech-language pathologists rated believability of videos online. Persons with aphasia rated aphasia videos during in-person sessions with the researchers.

Results

Targeted believability was 80 or higher (0–100 scale; 0 =
not at all believable
, 100 =
very believable
). For speech-language pathologist raters, average ratings met the target for the portrayals of the aphasia characteristics of word-finding problems, agrammaticism, nonverbal communication, and overall portrayal but not for auditory comprehension problems. Targets for the portrayals were met for the dysarthria characteristics of reduced speech movements, reduced loudness, reduced intonation, flat affect, and overall portrayal but not for speech rate. Ratings for different standardized patients portraying the same case were not significantly different from each other on most characteristics. Ratings from persons with aphasia were highly variable.

Conclusion
Standardized patients who do not have communication disorders can portray disorder characteristics in a believable manner.
Numerical investigation of electric field distortion induced by internal defects in composite insulators
Authors: Kone Gbah , Volat Christophe , Ezzaidi Hassan 
Published: June 2017

This paper presents an exhaustive study of numerical investigations based on three‐dimensional finite‐element method modelling of several non‐ceramic insulators of 69, 110 and 230 kV having different internal semi‐conductive defects in terms of size and position. The internal defects were positioned close to the high‐voltage electrode, the ground electrode and at floating potential. The simulations effected on the distortion of the axial and radial E‐field components close to the insulator shank between sheds. The results obtained showed that the radial E‐field component is more sensitive to the presence of an internal defect as it shows a greater distortion in presence of the defect. It was also observed that the E‐field component distortion increases with longer internal defect and that this increase is particularly important for a defect at floating potential. Moreover, it was demonstrated that the length of the insulator, for a defect of constant length, has no significant influence on the E‐field component distortion. Finally, the results demonstrated that the presence of a grading ring, as used on the 230 kV insulator, does not have any influence on the E‐field component distortion, independently of the defect position.
Feature extraction and classification method for switchgear faults based on sample entropy and cloud model
Authors: Cui Jindong , Zheng Que , Xin Yechun , Zhou Chuan , Wang Qianggang , Zhou Niancheng 
Published: June 2017

This study proposes a fault diagnosis method for extracting and classifying the fault features of switchgears in accordance with the monitoring data of three‐phase voltage and current, temperature, humidity, and flashing from the smart breaker and sensors. The fault features are calculated using multivariate multiscale sample entropy (MMSE) for the data mining of multivariate monitoring process. The similarity measure of the composite delay vectors of multivariate time series in MMSE is improved by introducing a cloud model to soften the similar tolerance criterion. The modified MMSE is defined as multivariate multiscale cloud sample entropy (MMCSE). The MMCSE features of switchgear monitoring data can be achieved in different time scales in describing various switchgear faults. Subsequently, a classification method based on fuzzy support vector machine (FSVM) is further adopted to identify different types of switchgear faults using the MMCSE features. In addition, a dropping semi‐normal membership cloud model is applied to modify the uncertainty quantification of the relationship among fault samples in FSVM. The effectiveness of the proposed method is validated with the monitoring data in a 10 kV switchboard.
The method of shifted partial derivatives cannot separate the permanent from the determinant
Authors: Efremenko Klim , Landsberg J. , Schenck Hal , Weyman Jerzy 
Published: June 2017

The method of shifted partial derivatives introduced A. Gupta et al. [Approaching the chasm at depth four, IEEE Comp. Soc., 2013, pp. 65-73] and N. Kayal [An exponential lower bound for the sum of powers of bounded degree polynomials, ECCC 19, 2010, p. 81], was used to prove a super-polynomial lower bound on the size of depth four circuits needed to compute the permanent. We show that this method alone cannot prove that the padded permanent

ℓ

n
−
m

p
e
r
m

m

\ell ^{n-m}\mathrm {perm}_m

cannot be realized inside the

G

L

n
2

GL_{n^2}

-orbit closure of the determinant

d
e
t

n

\mathrm {det}_n

when

n
>
2

m
2

+
2
m

n>2m^2+2m

. Our proof relies on several simple degenerations of the determinant polynomial, Macaulay’s theorem, which gives a lower bound on the growth of an ideal, and a lower bound estimate from [Approaching the chasm at depth four, IEEE Comp. Soc., 2013, pp. 65-73] regarding the shifted partial derivatives of the determinant.
The degenerate Eisenstein series attached to the Heisenberg parabolic subgroups of quasi-split forms of 𝑆𝑝𝑖𝑛₈
Authors: Segal Avner 
Published: June 2017

In [J. Inst. Math. Jussieu 14 (2015), 149–184] and [Int. Math. Res. Not. IMRN 7 (2017), 2014–2099] a family of Rankin-Selberg integrals was shown to represent the twisted standard

L

\mathcal {L}

-function

L

(
s
,
π
,
χ
,

s
t

)

\mathcal {L}(s,\pi ,\chi ,\mathfrak {st})

of a cuspidal representation

π
\pi

of the exceptional group of type

G
2

G_2

. These integral representations bind the analytic behavior of this

L

\mathcal {L}

-function with that of a family of degenerate Eisenstein series for quasi-split forms of

S
p
i

n
8

Spin_8

associated to an induction from a character on the Heisenberg parabolic subgroup.

This paper is divided into two parts. In Part 1 we study the poles of these degenerate Eisenstein series in the right half-plane

R
e

(
s
)
>
0

\mathfrak {Re}(s)>0

. In Part 2 we use the results of Part 1 to prove the conjecture, made by J. Hundley and D. Ginzburg in [Israel J. Math. 207 (2015), 835–879], for stable poles and also to give a criterion for

π
\pi

to be a CAP representation with respect to the Borel subgroup of

G
2

G_2

in terms of the analytic behavior of

L

(
s
,
π
,
χ
,

s
t

)

\mathcal {L}(s,\pi ,\chi ,\mathfrak {st})

at

s
=

3
2

s=\frac {3}{2}

.
omiXcore: a web server for prediction of protein interactions with large RNA
Authors: Armaos Alexandros , Cirillo Davide , Gaetano Tartaglia Gian 
Published: June 2017

Abstract

Summary
Here we introduce omiXcore, a server for calculations of protein binding to large RNAs (&gt; 500 nucleotides). Our webserver allows (i) use of both protein and RNA sequences without size restriction, (ii) pre-compiled library for exploration of human long intergenic RNAs interactions and (iii) prediction of binding sites.

Results
omiXcore was trained and tested on enhanced UV Cross-Linking and ImmunoPrecipitation data. The method discriminates interacting and non-interacting protein-RNA pairs and identifies RNA binding sites with Areas under the ROC curve &gt; 0.80, which suggests that the tool is particularly useful to prioritize candidates for further experimental validation.

Availability and implementation
omiXcore is freely accessed on the web at http://service.tartaglialab.com/grant_submission/omixcore.

Supplementary information
Supplementary data are available at Bioinformatics online.
Wound Complication Rates After Staples or Suture for Midline Vertical Skin Closure in Obese Women
Authors: Kuroki Lindsay M. , Mullen Mary M. , Massad L. Stewart , Wu Ningying , Liu Jingxia , Mutch David G. , Powell Matthew A. , Hagemann Andrea R. , Thaker Premal H. , McCourt Carolyn K. , Novetsky Akiva P. 
Published: June 2017

OBJECTIVE:
To compare wound complication rates after skin closure with staples and subcuticular suture in obese gynecology patients undergoing laparotomy through a midline vertical incision.

METHODS:
In this randomized controlled trial, women with body mass indexes (BMIs) of 30 or greater undergoing surgery by a gynecologic oncologist through a midline vertical incision were randomized to skin closure with staples or subcuticular 4-0 monofilament suture. The primary outcome was the rate of wound complication, defined as the presence of a wound breakdown, or infection, within 8 weeks postoperatively. Secondary outcomes included operative time, Stony Brook scar cosmetic score, and patient satisfaction. A sample size of 162 was planned to detect a 50% reduction in wound complications. At planned interim review (n=82), there was no significant difference in primary outcome.

RESULTS:
Between 2013 and 2016, 163 women were analyzed, including 84 who received staples and 79 suture. Women who received staples were older (mean age 59 compared with 57 years), had lower mean BMI (37.3 compared with 38.9), and fewer benign indications for surgery (22 compared with 27). There were no differences in wound complication rates between staple compared with suture skin closure (28 [33%] compared with 25 [32%], relative risk 1.05, 95% confidence interval [CI] 0.68–1.64). Women with staples reported worse median cosmetic scores (four of five compared with five of five, P<.001), darker scar color (37 [49%] compared with 13 [18%], relative risk 2.69, 95% CI 1.57–4.63), and more skin marks (30 [40%] compared with three [4%], relative risk 9.47, 95% CI 3.02–29.65) compared with women with suture closure. There was no group difference regarding satisfaction with their scar. Stepwise multivariate analysis revealed BMI (odds ratio [OR] 1.13, 95% CI 1.07–1.20), maximum postoperative glucose (OR 1.01, 95% CI 1.00–1.01), and cigarette smoking (OR 4.96, 95% CI 1.32–18.71) were correlates of wound complication.

CONCLUSION:
Closure of midline vertical skin incisions with subcuticular suture does not reduce surgical site wound complications compared with staples in obese gynecology patients.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT01977612.
False Labor at Term in Singleton Pregnancies
Authors: Nelson David B. , McIntire Donald D. , Leveno Kenneth J. 
Published: June 2017

OBJECTIVE:
To evaluate perinatal outcomes in women sent home with a diagnosis of false labor at term and assess the time interval to return for delivery.

METHODS:
This was a prospective observational cohort study of women at 37 0/7 to 41 6/7 weeks of gestation without pre-existing medical complications who presented to our hospital-based triage unit with symptoms of labor and underwent a standardized evaluation. Women diagnosed as having false labor with a live singleton fetus in cephalic presentation without a prior cesarean delivery and sent home were compared with a group of similar women diagnosed to be in spontaneous labor. Women with hypertension, diabetes, and known fetal malformations were excluded. Using a perinatal composite outcome of respiratory insufficiency, intraventricular hemorrhage, culture-proven sepsis, Apgar score 3 or less at 5 minutes, phototherapy, and perinatal death, we tested the noninferiority of being sent home compared with being admitted for labor. The relationship of cervical dilatation to the time interval from discharge home to delivery was also analyzed.

RESULTS:
Between October 2012 and March 2016, a total of 3,949 women met inclusion criteria and were diagnosed with false labor, discharged, and returned to deliver, whereas 2,592 similar women were admitted in early labor. The mean interval from discharge to return was 4.9 days. Cesarean delivery rates were not different between the study groups—11% for both (P=.69), and the perinatal composite outcome rates were not significantly different between those sent home and those admitted—3.2% compared with 3.1% (P=.79). Women with more advanced cervical dilatation at discharge returned and delivered significantly earlier than those with less dilatation regardless of parity.

CONCLUSION:
Discharge with false labor at term after a standardized assessment in a triage unit was not associated with increased rates of adverse perinatal composite outcomes or cesarean delivery. The time interval to return for delivery was significantly associated with the cervical dilatation at discharge.
Timing of Etonogestrel-Releasing Implants and Growth of Breastfed Infants
Authors: Carmo Lilian Sheila de Melo Pereira , Braga Giordana Campos , Ferriani Rui Alberto , Quintana Silvana Maria , Vieira Carolina Sales 
Published: June 2017

OBJECTIVE:
To evaluate the growth of breastfed infants whose mothers had inserted an etonogestrel-releasing implant in the immediate postpartum period.

METHODS:
An open, randomized controlled, and parallel trial of postpartum women who were block-randomized to early (up to 48 hours postpartum before discharge) or conventional (at 6 weeks postpartum) insertion of an etonogestrel implant. The primary outcome was average infant weight at 12 months (360 days) and a difference of equal to or greater than 10% between groups was considered clinically significant. The secondary outcomes were infant's height and head and arm circumferences. These variables were measured at baseline and at 14, 40, 90, 180, 270, and 360 days postpartum. The mixed-effects linear regression model was used to evaluate the outcomes with a power of 80% and a significance level of 1% for the primary outcome and 0.3% for secondary outcomes as a result of correction for multiple hypothesis testing.

RESULTS:
From June to August 2015, a total of 100 women were randomized: 50 to early and 50 to conventional postpartum etonogestrel insertion. Sociodemographic characteristics were similar between the groups, except for educational attainment. The conventional insertion group included a higher proportion of women with 8 or more years of formal education than the early insertion group (88% [44/50] compared with 70% [35/50], P=.02). There was no difference in infant weight at 360 days between the groups (early [mean±standard deviation] 10.1±1.2 kg compared with conventional 9.8±1.3 kg, mean difference estimate 0.3 kg, 95% confidence interval 0–0.7 kg). Growth curves, height, and head and arm circumferences did not differ between the groups.

CONCLUSION:
There is no difference in growth at 12 months among breastfed infants whose mothers underwent early compared with conventional postpartum insertion of the etonogestrel implant.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT02469454.
Associations of Parity, Breastfeeding, and Fractures in the Women's Health Observational Study
Authors: Crandall Carolyn J. , Liu Jingmin , Cauley Jane , Newcomb Polly A. , Manson JoAnn E. , Vitolins Mara Z. , Jacobson Lisette T. , Rykman Kelli K. , Stefanick Marcia L. 
Published: June 2017

OBJECTIVE:To examine associations of several aspects of parity and history of lactation with incident hip fractures and clinical fractures and, in a subset of women, with bone mineral density.METHODS:In this observational study, we analyzed data from 93,676 postmenopausal women participating in the Women's Health Initiative Observational Study and all bone density data from the subset of participants who underwent bone density testing at three clinical centers. At baseline, participants were aged 50–79 years. Using Cox proportional hazards regression analysis, we examined associations of fracture incidence and bone density with several aspects of parity (number of pregnancies, age at first pregnancy lasting 6 months or greater, and number of pregnancies lasting 6 months or greater) and breastfeeding (number of episodes of breastfeeding for at least 1 month, number of children breastfed, age when first breastfed, age when last breastfed, total number of months breastfed).RESULTS:The mean baseline age (standard deviation) of participants was 64 (±7.4) years (mean follow-up 7.9 years). During follow-up, the incident rate of hip fracture was 1.27%. Ten percent of participants were nulligravid. In fully adjusted models, number of pregnancies, parity, age at first birth, number of children breastfed, age at first breastfeeding, age at last breastfeeding, and total duration of breastfeeding were not statistically significantly associated with hip fracture incidence. There were no consistent associations of parity or lactation characteristics with overall clinical fracture risk or bone density. However, compared with never breastfeeding, a history of breastfeeding for at least 1 month was associated with a decreased risk of hip fracture (yes compared with no, hazard ratio 0.84, 95% confidence interval 0.73–0.98).CONCLUSION:Patterns of parity and history of lactation were largely unrelated to fracture risk or bone density.
Patterns of Specialty-Based Referral and Perioperative Outcomes for Women With Endometrial Cancer Undergoing Hysterectomy
Authors: Wright Jason D. , Chen Ling , Gabor Lisa , Burke William M. , Tergas Ana I. , Hou June Y. , Ananth Cande V. , Neugut Alfred I. , Hershman Dawn L. 
Published: June 2017

OBJECTIVE:
To examine patterns of referral to gynecologic oncologists and perioperative outcomes based on surgeon specialty for women with endometrial cancer and hyperplasia.

METHODS:
The National Surgical Quality Improvement Program database was used to perform a retrospective cohort study of women with endometrial cancer and hyperplasia who underwent hysterectomy from 2014 to 2015. Patients were stratified based on treatment by a gynecologic oncologist or other health care provider. Patterns of referral to a gynecologic oncologist was the primary outcome, and mode of hysterectomy and complications were secondary outcomes.

RESULTS:
A total of 6,510 women were identified. Gynecologic oncologists performed 90.9% (95% confidence interval [CI] 90.1–91.7) of the hysterectomies for endometrial cancer, 66.8% (95% CI 63.1–70.4) for complex atypical endometrial hyperplasia, and 49.3% (95% CI 44.7–53.8) for endometrial hyperplasia without atypia. Older women and those with a higher American Society of Anesthesiology score were more likely to be treated by an oncologist. Minimally invasive hysterectomy was performed in 73.6% (95% CI 72.1–75.1) of women with endometrial cancer operated on by gynecologic oncologists compared with 73.8% (95% CI 68.8–78.2) of those treated by other physicians (odds ratio [OR] 0.99, 95% CI 0.80–1.23); lymphadenectomy was performed in 56.3% of women treated by gynecologic oncologists compared with 34.8% of those treated by other specialists (OR 2.42, 95% CI 1.99–2.94). Severe complications were uncommon and there was no difference in complication rates based on specialty, 2.6% (95% CI 2.2–3.1) compared with 2.0% (95% CI 0.8–3.3).

CONCLUSION:
Gynecologic oncologists provide care for the majority of women with endometrial cancer who undergo hysterectomy in the United States and are also involved in the care of a large percentage of women with endometrial hyperplasia.
All-Cause Mortality After Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer
Authors: Melamed Alexander , Rizzo Anthony E. , Nitecki Roni , Gockley Allison A. , Bregar Amy J. , Schorge John O. , del Carmen Marcela G. , Rauh-Hain J. Alejandro 
Published: June 2017

OBJECTIVE:To compare all-cause mortality between women who underwent fertility-sparing surgery with those who underwent conventional surgery for stage I ovarian cancer.METHODS:In a cohort study using the National Cancer Database, we identified women younger than 40 years diagnosed with stage IA and unilateral IC epithelial ovarian cancer between 2004 and 2012. Fertility-sparing surgery was defined as conservation of one ovary and the uterus. The primary outcome was time from diagnosis to death. We used propensity score methods to assemble a cohort of women who underwent fertility-sparing or conventional surgery but were otherwise similar on observed covariates and conducted survival analyses using the Kaplan–Meier method and Cox proportional hazard models.RESULTS:We identified 1,726 women with stage IA and unilateral IC epithelial ovarian cancer of whom 825 (47.8%) underwent fertility-sparing surgery. Fertility-sparing surgery was associated with younger age, residence in the northeastern and western United States, and serous or mucinous histology (P<.05 for all). Propensity score matching yielded a cohort of 904 women who were balanced on observed covariates. We observed 30 deaths among women who underwent fertility-sparing surgery and 37 deaths among propensity-matched women who underwent conventional surgery after a median follow-up of 63 months. Fertility-sparing surgery was not associated with hazard of death (hazard ratio 0.80, 95% confidence interval [CI] 0.49–1.29,P=.36). The probability of survival 10 years after diagnosis was 88.5% (95% CI 82.4–92.6) in the fertility-sparing group and 88.9% (95% CI 84.9–92.0) in the conventional surgery group. In patients with high-risk features such as clear cell histology, grade 3, or stage IC, 10-year survival was 80.5% (95% CI 68.5–88.3) among women who underwent fertility-sparing surgery and 83.4% (95% 76.0–88.7) among those who had conventional surgery (hazard ratio 0.86, 95% CI 0.49–1.53,P=.61).CONCLUSION:Compared with conventional surgery, fertility-sparing surgery was not associated with increased risk of death in young women with stage I epithelial ovarian cancer.