bluuebunny/crossref_metadata_2025_split huggingface dataset:
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THERAPY-RELATED MYELOID NEOPLASMS (t-MN) OF THE ADULT: MONOCENTRIC OBSERVATIONAL STUDY AND REVIEW OF THE LITERATURE.
Authors: Metafuni Elisabetta , Chiusolo Patrizia , Laurenti Luca , Sorà Federica , Giammarco Sabrina , Bacigalupo Andrea , Leone Giuseppe , Sica Simona 
Published: December 2017

Abstract Background: Therapy-related myeloid neoplasms (t-MN) occur due to direct mutational events of chemotherapeutic agents and radiotherapy. Disease latency, mutational events, and prognosis vary with drugs categories.Methods: We describe a cohort of 30 patients, 18 females and 12 males, with a median age of 52.5 years (range, 20 to 64), submitted to allogeneic stem cell transplantation (HSCT) in our department between September 1999 and March 2017. Patients had a history of a solid tumor in 14 cases, a hematological disease in 15 cases and both of them in one case. After a median of 36.5 months (range, 4 to 190) from the first neoplasm, patients developed t-AML in 19 cases and t-MDS in 11 cases. Molecular abnormalities were detected in 5 patients, while karyotype aberrations were found in 17 patients. Patients received conventional chemotherapy in 14 cases, azacitidine in 10 cases and both of them in one case. Five patients were submitted to HSCT without previous treatment except for supportive therapy.Results: Seventeen patients obtained sustained CR after SCT, while 8 patients showed resistant or relapsed disease. The remaining five patients died early after SCT. At follow up time (May 2017) 13 patients were alive with a median OS of 48 months (range 3-195), while 17 patients died after a median of 4 months (range 1-27) by relapse mortality in 6 cases and non-relapse mortality in the other 11 patients.Conclusions: Global OS was 43%. After SCT 56.7% of patients with t-MN obtained and maintained CR.Keywords: Therapy-related myeloid neoplasm; Hematopoietic stem cell transplantation; Secondary leukemia.
NEGATIVE IMPACT OF PROLONGED ANTIBIOTICS OR PERSISTENT DIARRHEA ON VITAMIN K1 LEVELS IN 2-24 WEEKS AGED EGYPTIAN INFANTS
Authors: Elalfy Mohsen , Ebeid Fatma S E , Elagouza Iman , Ibrahim Fatma , Hassan Noura , Botros Beshoy 
Published: December 2017

Objectives: To evaluate the hazard of prolonged antibiotic therapy and/or persistent diarrhea on vitamin K1 (VK1) level and bleeding profile in infants (2-24 weeks). Methods: A one-year case-control study, conducted at Ain Shams University, Egypt. 338 infants (2-24 weeks) were recruited and divided into 3 groups (1:1:3 ratios); group A (n= 67) patients who received antibiotics for ≥10 days, group B (n= 67) who had persistent diarrhea ≥ 14 days and group C (n=204) age- and gender-matched infants who were not either received antibiotics nor had diarrhea. All subjected to clinical assessment, bleeding history and had their complete blood count (CBC), PT and PTT, liver transaminases and VK1 level assayed. Results: There was a significant increase in the frequency of VKDB (vitamin K deficiency bleeding) and abnormal bleeding profile in cases than the control group. There was a significant negative correlation between VK1 level and duration of diarrhea, length of antibiotics used and bleeding profile. Antibiotic usage has a dangerous effect on the VK1 level in those with diarrhea; more patients were receiving antibiotic in those with persistent diarrhea and VKDB (N=55) than those with persistent diarrhea and normal VK1 (N=12). The longer duration of antibiotic therapy the lower level of VK1. Combining cephalosporins/penicillins therapy and/or diarrhea, in particular, had an impact on the VK1 level. Conclusion: VKDB, a preventable cause of life-threatening hemorrhage, is still a major health problem in Egyptian infants, where persistent diarrhea and misuse of antibiotics are prevalent, necessitate a booster dose of VK in those high risk infants.Keyword: Prolonged Antibiotics; Persistent Diarrhea; Vitamin K1; Egyptian
Synovial tuberculosis of the hand: An ancient disease in an unusual localisation
Authors: Ramos Renato Franz Matta , Cancian Lucas , Calcagnotto Fernando , Zeni Ricardo , Varela Gabriel , Burgues Tamsin , Silva Jefferson Braga 
Published: December 2017

ABSTRACTBackground: Tuberculosis is the most prevalent infectious disease in the world. It is mainly caused by Mycobacterium tuberculosis. Osteoarticular tuberculosis represents 1%–3%. Tenosynovitis is the most common form of the disease in the hand. Aims: The aim of this study is to present an update of synovial tuberculosis. Materials and Methods: The authors present a literature review, the clinical and surgical management and case reports. Results: The outcomes were satisfactory and were not report complications. Conclusions: Early diagnosis, surgical transection of the transverse carpal ligament, debridement and complete excision of the infected synovium may be required, along with antituberculosis drugs. Knowledge of this disease in the hand can provide a better diagnosis and outcome.
Dilemma of diagnosing thoracic sarcoidosis in tuberculosis endemic regions: An imaging-based approach. Part 1
Authors: Bhalla Ashu S , Das A , Naranje P , Goyal A , Guleria R , Khilnani Gopi C 
Published: December 2017

AbstractSarcoidosis is a multi-systemic disorder of unknown etiology, although commonly believed to be immune-mediated. Histologically, it is characterized by noncaseating granuloma which contrasts against the caseating granuloma seen in tuberculosis (TB), an infectious disease that closely mimics sarcoidosis, both clinically as well as radiologically. In TB-endemic regions, the overlapping clinico-radiological manifestations create significant diagnostic dilemma, especially since the management options are markedly different in the two entities. Part 1 of this review aims to summarize the clinical, laboratory, and imaging features of sarcoidosis, encompassing both typical and atypical manifestations, in an attempt to distinguish between the two disease entities.
Radiological spectrum of anthracofibrosis: A series of 40 patients with computed tomography, bronchoscopy, and biopsy
Authors: Dhar Anandamoyee , Sikund Kunal , Lall Ajal , Aggarwal Bharat 
Published: December 2017

Abstract
Introduction: Anthracofibrosis is a lesser known clinical entity. Patients present with chronic symptoms of cough and breathlessness with a history of biofuel/wood fire smoke exposure. There are distinct computed tomography (CT) imaging features of anthracofibrosis that can differentiate it from more common conditions such as tuberculosis (TB) and bronchogenic carcinoma. Findings include multifocal noncontiguous stenosis of bronchial tree, calcified enlarged mediastinal or hilar nodes, and secondary lung parenchymal changes. However, in TB, bronchostenosis usually involves a single lobar bronchus in a contiguous manner with trachea and/or major bronchi also being affected. In this study, we highlight the imaging characteristics of anthracofibrosis. Context: The CT findings of anthracofibrosis closely mimic TB and bronchogenic carcinoma, hence we highlight the key imaging features of anthracofibrosis. Aims and Objectives: To identify and describe the CT imaging features of anthracofibrosis and correlate it with bronchoscopic findings. Setting and Design: Retrospective study. Materials and Methods: Retrospectively, 40 patients were selected who were diagnosed with anthracofibrosis on bronchoscopy and biopsy. However, CT scan records of only 14 patients were available for review. Two radiologists reviewed the scans independently. Results: Most common CT finding was multisegmental noncontiguous bronchostenosis seen in 93% patients mostly involving the right middle lobe. 85% of the cases showed lymph node enlargement involving hilar, peribronchial, and mediastinal nodes. The nodes were calcified in 91.7% of the cases, with 58% showing pressure effect on adjacent bronchi due to nodal enlargement. The next common findings were peribronchial cuffing and bronchial obstruction seen in 57 and 28% of the cases, respectively. Conclusion: The key imaging features of anthracofibrosis on CT are multifocal involvement of bronchi with smooth peribronchial thickening and enlarged calcified lymph nodes.
Appraisal of radiation dose with 64-slice computed tomography perfusion in lung cancer patients with special reference to SSDE: An initial experience in a tertiary care hospital
Authors: Bhatt Shuchi , Srivastava Ajai K , Meena Neha , Thakur Shweta 
Published: December 2017

Abstract
Context: Computed tomography perfusion (CTP) is an important functional tool for lung cancer. It is expected to deliver high radiation dose, making its accurate estimation important. Size-specific dose estimate (SSDE) is a new dose metric, which includes the scanner output as well as the patient size. Aims: To determine radiation dose [CT dose index (CTDIvol), dose length product (DLP), effective dose (ED), and SSDE] for CTP in lung cancer and the correlation of CTDIvol, DLP, and SSDE with effective diameter and SSDE with weight, body mass index (BMI), and the scan length. Settings and Design: Cross-sectional study in the Department of Radio-diagnosis from October 2015 to March 2016. Patients and Methods: Due ethical approval and informed consent was taken. Thirty consecutive adult patients of lung cancer undergoing CTP study were included; various radiation dose parameters were determined and presented as mean ± SD. Statistical Analysis Used: Paired Student's t-test and Pearson correlation using Statistical Package for the Social Sciences, Version 16. Results: Mean radiation dose was CTDIvol = 270.138 ± 1.627 mGy, DLP = 681 ± 53.496 mGy.cm, ED = 12.501 ± 0.923 mSv, SSDE = 388.90 ± 81.27 mGy. The CTDIvol and DLP had significant positive correlation (r = 0.556, P= 0.000 and r = 0.522, P= 0.003, respectively) with effective diameter. SSDE had strong negative correlation (r = −0.997, P= 0.000) with effective diameter, significant negative correlation with the BMI (r = −0.889; P= 0.000) and weight (r= −0.910, P= 0.000) of patients. Scan length was not significantly correlated in SSDE (r = −0.012, P= 0.951). Conclusions: Smaller sized patients had greater SSDE.
Review of imaging in post-laparoscopy cholecystectomy complications
Authors: Sureka Binit , Mukund Amar 
Published: December 2017

AbstractLaparoscopic cholecystectomy is now considered the procedure of choice for uncomplicated symptomatic gallstone disease worldwide. Various biliary, vascular, gastrointestinal, neurological and local complications may be seen on imaging post surgery. Knowledge of these entities and imaging appearances is indispensable for the radiologist in today's era. We emphasize on the list of potential complications and imaging appearances of this surgical procedure.
Programmatic Assessment in Emergency Medicine: Implementation of Best Practices
Authors: Perry Marcia , Linn Andrew , Munzer Brendan W. , Hopson Laura , Amlong Ambrosya , Cole Michael , Santen Sally A. 
Published: December 2017

ABSTRACT

Background
Programmatic assessment is the intentional collection of key data from multiple sources for both assessment of learning and assessment for learning.

Objective
We developed a system of programmatic assessment (PA) to identify competency progression (summative) and assessment for learning to assist residents in their formative development.

Methods
The programmatic assessment was designed iteratively from 2014 through 2016. All assessments were first categorized by competency domain and source of assessment. The number of assessment modalities for each competency domain was collected. These multisource assessments were then mapped by program leadership to the milestones to develop a master PA blueprint. A resident learning management system provided the platform for aggregating formative and summative data, allowing residents and faculty ongoing access to guide learning and assessment. A key component of programmatic assessment was to support resident integration of assessment information through feedback by faculty after shifts and during monthly formal assessments, semiannual resident reviews, and summative judgments by the Clinical Competency Committee.

Results
Through the PA, the 6 competency domains are assessed through multiple modalities: patient care (22 different assessments), professionalism (18), systems-based practice (17), interprofessional and communication skills (16), medical knowledge (11), and practice-based learning and improvement (6). Each assessment provides feedback to the resident in various formats. Our programmatic assessment has been utilized for more than 2 years with iterative improvements.

Conclusions
The implementation of programmatic assessment allowed our program to organize diverse, multisourced feedback to drive both formative and summative assessments.
Propolis: A Smart Supplement for an Intracanal Medicament
Authors: Avinash Alok , Munot Harsha , Baranwal Rashmi , Duggi Vijay , Dubey Alok , Pagaria Sulabh 
Published: December 2017

ABSTRACTIntroductionOne of the most important factors for successful endodontic therapy is root canal cleaning. The difficulty involved in eliminating microorganisms, as well as their residual presence, warrants the use of root canal dressings after biomechanical preparation.AimThe aim of the study was to compare the diffusion ability between nonalcoholic calcium hydroxide—propolis paste, calcium hydroxide—saline paste, and calcium hydroxide—propylene glycol paste.Materials and methodsFor this proposed study, single-rooted extracted permanent teeth were randomly divided into three groups to fill the canals: group I: Calcium hydroxide—propylene glycol paste, group II: Calcium hydroxide—saline paste, and group III: Calcium hydroxide—propolis paste. After complete filing of the root canal, the pH values of the solutions in the flasks are measured at an interval of 3, 24, 72, 168 hours.ResultsAfter 168-hour interval, it was noticed that the mean pH obtained by calcium hydroxide—propolis paste was 10.54 (± 0.38), which was greater than calcium hydroxide—propylene glycol paste 9.70 (± 0.45) and calcium hydroxide—saline paste 9.16 (± 0.30) consecutively.ConclusionThe nonalcoholic calcium hydroxide—propolis paste used during the study was able to diffuse through the dentinal tubules. Thus, it can be used as a vehicle for calcium hydroxide.How to cite this articleBaranwal R, Duggi V, Avinash A, Dubey A, Pagaria S, Munot H. Propolis: A Smart Supplement for an Intracanal Medicament. Int J Clin Pediatr Dent 2017;10(4):324-329.
Influence of Trainee Experience on Choice of Orthopaedic Subspecialty Fellowship
Authors: Matson Andrew P. , Kavolus Joseph J. , Byrd William A. , Leversedge Fraser J. , Brigman Brian E. 
Published: December 2017

Introduction:
Most orthopaedic surgery residents elect to pursue additional subspecialty training; however, factors influencing the choice of subspecialty and the ways that these factors change during training are not well understood. The aim of this investigation was to determine, on the basis of a trainee’s postgraduate year (PGY), whether variability exists in factors valued when choosing a specific subspecialty.

Methods:
We emailed an online survey (intended for distribution to current trainees) to a list of orthopaedic surgery residency program coordinators in the United States. The survey queried demographic information, PGY level, and the importance of 14 discrete factors in the selection of fellowship specialty according to a Likert scale rating from 1 to 4.

Results:
There were 359 respondents representing an even distribution of PGY levels. Junior trainees assigned greater relative value to geographic location, on-call responsibilities, financial compensation, and the tradition of the residency program, whereas senior trainees assigned greater relative value to variety of cases and intellectual stimulation (all P < 0.05).

Discussion:
The differences seen in factors valued based on trainee experience may highlight the relative importance of greater exposure to the breadth of orthopaedic surgical practice during training and increasing awareness of clinical competencies and responsibilities.

Conclusions:
When deciding on orthopaedic subspecialty choice, junior trainees value lifestyle factors relatively more than do senior trainees, whereas senior trainees value case variety and stimulation relatively more than junior trainees do.
Compliance With the AAOS Guidelines for Treatment of Osteoarthritis of the Knee: A Survey of the American Association of Hip and Knee Surgeons
Authors: Carlson Victor Rex , Ong Alvin Chua , Orozco Fabio Ramiro , Hernandez Victor Hugo , Lutz Rex William , Post Zachary Douglas 
Published: December 2017

Introduction:
The American Academy of Orthopaedic Surgeons (AAOS) published a series of evidence-based guidelines for treatment of knee osteoarthritis (OA). We studied compliance with these guidelines among orthopaedic surgeons.

Methods:
We sent a survey to members of the American Association of Hip and Knee Surgeons. It included five clinical vignettes based on the Kellgren-Lawrence radiographic system for classification of knee OA. Respondents selected treatment currently supported or not supported by the AAOS guidelines.

Results:
Of 345 responses, the frequency of use of recommended interventions was 80%, 82%, 21%, 50%, and 98% for OA at stages 0 through 4, respectively. For stage 2 and stage 3 OA, intra-articular hyaluronic acid was the most commonly selected intervention not recommended by the AAOS.

Discussion:
Apparently, AAOS guidelines on the treatment of OA have not reached the orthopaedic community, resulting in lack of treatment consensus and continued use of modalities with no proven patient benefits.

Conclusions:
Management of moderate to severe knee OA does not align with AAOS guidelines. We encourage researchers to conduct clinical trials to identify the role of intra-articular corticosteroids in treating this condition.
Information Literacy: Business and Workplace Information Literacy: Three Perspectives
Authors: Malafi Elizabeth , Liu Grace , Goldstein Stéphane 
Published: December 2017

Businesses want workers who are critical thinking problem-solvers, who know how to find, evaluate, and use information to address work-related issues, and communicate effectively regarding those issues,1 much like the information literacy (IL) or media and information literacy (MIL) efforts worldwide recently described in this column.2 In businesses at all levels and in the workplace, IL/MIL is not a familiar phrase. Undaunted, however, librarians in many types of libraries try to help their users with these very issues. Those librarians face challenges, including constant and rapid change in directions and needs, little or no grasp of the availability of data (or lack thereof), especially on emerging topics, and the need to address and communicate work-related issues speedily, yet with valid evidence. The challenge for librarians in all types of libraries is how to support each other through sharing materials and approaches, perhaps in a new repository for workplace-related IL. The discussions that follow take a first step in that direction. Next steps could include analyzing the contents of such a repository and developing sequential supportive curricula and materials for librarians and for their users to extend and expand their business and workplace IL.—Esther Grassian, Co-Editor
Grain Boundary Sliding in High‐Temperature Deformation of Directionally Solidified hcp Zn Alloys and Implications for the Deformation Mechanism of Earth's Inner Core
Authors: Bergman Michael I. , Yu James , Lewis Daniel J. , Parker Grant K. 
Published: December 2017

AbstractEarth's inner core exhibits elastic anisotropy, but the cause of the texturing is uncertain: solidification, deformation, or some combination. In experiments presented here we deformed in torsion directionally solidified Zn‐3 wt pct Sn alloys at 0.97 of the melting temperature of pure Zn. We used a Zn‐rich alloy because Zn is hexagonal close‐packed at atmospheric pressure, as is likely Fe under inner core conditions. The directionally solidified alloys have the textured, columnar dendritic microstructure that has been proposed for the inner core. As a control we deformed in torsion the same alloy at the same temperature, but with a starting microstructure that is comparatively fine‐grained, equiaxed, and untextured. We find evidence that the directionally solidified alloys deform by means of grain boundary sliding, presumably accompanied by diffusion near the ends of the columnar crystals in order to preserve macroscopic shape. We also find that the directionally solidified alloys require approximately 3 times the torque to deform to the same strain than do the untextured alloys. Grain boundary sliding and greater hardness are due to insufficient slip systems to accommodate the strain, as a result of the texturing. This is supported by microcracking in the deformed directionally solidified alloys. Although the inner core is unlikely to exhibit semibrittle deformation, the experiments suggest that a directionally solidified inner core could have a higher viscosity than one with a finer‐grained, untextured microstructure and that grain boundary sliding may be a dominant deformation mechanism, in spite of the large grain size.
Segmentation of Slow Slip Events in South Central Alaska Possibly Controlled by a Subducted Oceanic Plateau
Authors: Li Haotian , Wei Meng , Li Duo , Liu Yajing , Kim YoungHee , Zhou Shiyong 
Published: December 2017

AbstractRecent GPS observations show that slow slip events in south central Alaska are segmented along strike. Here we review several mechanisms that might contribute to this segmentation and focus on two: along‐strike variation of slab geometry and effective normal stress. We then test them by running numerical simulations in the framework of rate‐and‐state friction with a nonplanar fault geometry. Results show that the segmentation is most likely related to the along‐strike variation of the effective normal stress on the fault plane caused by the Yakutat Plateau. The Yakutat Plateau could affect the effective normal stress by either lowering the pore pressure in Upper Cook Inlet due to less fluids release or increasing the normal stress due to the extra buoyancy caused by the subducted Yakutat Plateau. We prefer the latter explanation because it is consistent with the relative amplitudes of the effective normal stress in Upper and Lower Cook Inlet and there is very little along‐strike variation in Vp/Vs ratio in the fault zone from receiver function analysis. However, we cannot exclude the possibility that the difference in effective normal stress results from along‐strike variation of pore pressure due to the uncertainties in the Vp/Vs estimates. Our work implies that a structural anomaly can have a long‐lived effect on the subduction zone slip behavior and might be a driving factor on along‐strike segmentation of slow slip events.