bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wistar rats with long-term streptozotocin-induced type 1 diabetes mellitus replicate the most relevant clinical, biochemical, and hematologic features of human diabetes / Sobolanii Wistar cu diabet zaharat tip 1 indus cu streptozotocina reproduc cele mai relevante caracteristici clinice, biochimice si hematologice ale diabetului uman
Authors: Scridon Alina , Perian Marcel , Marginean Alina , Fisca Ciprian , Vantu Adriana , Ghertescu Doina , Chevalier Philippe , Serban Razvan Constantin 
Published: January 2016

Abstract
Background: Experimental models are essential for clarifying the pathogenesis of diabetes mellitus (DM). We aimed to provide an exhaustive description of clinical, biochemical, and hematologic features of rats with streptozotocin (STZ)-induced DM.
Methods: Wistar rats were assigned to control (n=14) or DM (n=17) groups. DM was induced using STZ (60 mg/kg, i.p.). If STZ failed to induce DM, rats were reinjected with a similar STZ dose. Bodyweight, 24-h food and water intake were measured weekly during 28 weeks. At the end of the study lipid profile, kidney function, and complete blood count were assessed.
Results: STZ induced DM in 58.82% of rats. The second STZ administration induced DM in 71.43% of the remaining rats. Diabetics presented progressive, but less significant bodyweight increase than controls, and higher food and water consumption. At the end of the study, diabetics presented higher white blood cells count, glucose, triglycerides, total and low-density lipoprotein cholesterol, and lower creatinine clearance than controls (all p≤0.02). No significant difference was observed between diabetics injected once and those that were reinjected, in any of the studied parameters.
Conclusions: This study provides one of the longest follow-ups of rats with STZ-induced type 1 DM, demonstrating that the STZ-diabetic rat replicates the most relevant clinical, biochemical, and hematologic features of human diabetes. The present data also indicate, for the first time, that rats with initial unsuccessful STZ administration can be safely reinjected, with outcomes similar to those seen in rats receiving a single injection.
Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction
Authors: Hadadi Laszlo , Sus Ioana , Lakatos Eva Katalin , Serban Razvan Constantin , Scridon Alina , Demjen Zoltan , Dobreanu Dan 
Published: January 2016

Abstract
Coronary chronic total occlusion (CTO) is caused by organized thrombi or atherosclerotic plaque progression. The presence of a CTO is an independent predictor of mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI). Platelets have a crucial role in the pathophysiology of atherosclerosis. The aim of this retrospective study was to investigate platelet indices as predictors of CTO in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). A total number of 334 patients admitted for STEMI between January 2011 and December 2013 were included and divided in two groups based on the presence of CTO (48 patients in CTO+ group, 286 patients in CTO-group). Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), lymphocyte and neutrophil count determined on admission were analyzed. MPV was larger in patients with CTO compared with patients without CTO (p=0.02), as were PDW (p=0.03) and P-LCR (p=0.01). Platelet-to-lymphocyte ratio (PLT/LYM) was lower in patients with CTO: 105.2 (75.86-159.1) compared to 137 (97-188.1), p<0.01. Receiver-operator characteristic curve analysis identified an area under the curve of 0.61 (95%CI=0.57-0.67, p< 0.01) for PLT/LYM in predicting the presence of a CTO, with a cut-off value at 97.73. Lower values than this were independent predictors of a CTO in multivariate logistic regression analysis, with an Odds Ratio of 2.2 (95%CI=1.15-4.20, p=0.02). Our results support the use of platelet indices and PLT/LYM as predictors of CTO in patients presenting with STEMI.
Early changes of placenta-derived messenger RNA in maternal plasma – potential value for preeclampsia prediction?
Authors: Surugiu Sebastian , Chis Adina , Mare Codruta , Matei Horea , Stamatian Florin 
Published: January 2016

Abstract

Objective: the pourpose of the study was to determine if there are any differences between placenta derived plasmatic levels of messenger RNA in normal and future preeclamptic pregnancies and if these placental transcripts can predict preeclampsia long before clinical onset

Study design: we compared plasmatic expression of two placental transcripts from 12 women who ultimately developed preeclampsia with 224 controlled subjects, at the end of the first trimester of pregnancy. After multiplse-of-the-median conversion of markers we developed a multivariate model using logistic regression to determine preeclampsia risk.

Results: we found lower multiples of the median values for both placental transcripts (mRNA corresponding to placental growth factor and pregnancy associated plasmatic protein A) in cases who ultimately developed preeclampsia and the multivariate model we obtained offered a preeclampsia detection rate of 75% at 10% false positive rate.

Conclusion: specific early changes of placenta-derived messenger RNA could be used as preeclampsia predictors.
Transoesophageal echocardiography before DC cardioversion: a survey of clinical practice in the UK
Authors: Ahluwalia Nikhil , Bhattacharyya Sanjeev , Munns Christopher , Chambers John 
Published: January 2016

Abstract
Transoesophageal echocardiography (TOE) can be used to expedite DC cardioversion (DCCV) in the absence of adequate anticoagulation. There are no guidelines for the management of sedation or general anaesthetic. We performed a survey of NHS echocardiography departments to determine UK practice. Responses were received from 95 (50%) of 189 centres, and TOE-guided DCCV was performed in 81 centres. The numbers were <10 a year in 41 (50%), 10–50 in 31 (38%), 50–100 in 8 (10%) and >100 in 4 (5%) centres. Sedation for TOE was a usual practice in 67 (80%) centres but often temporally disconnected from DCCV due to logistical reasons. TOE under general anaesthetic was performed in 35 (43%) centres and as the usual method in 16 (20%). The patient was in the supine position with endotracheal intubation in 20 (57%) of centres, but without any form of airway protection while supine in 5 (14%). There is variability in practice across centres in the UK, in part due to limitations to services in most centres but also because of an absence of UK guidelines. The development of national standards may address this and aid in the development of local business cases to extend services.
Fecal transplantation indications in ulcerative colitis. Preliminary study
Authors: Laszlo Mihaela , Ciobanu Lidia , Andreica Vasile , Pascu Oliviu 
Published: January 2016

Background and aims. Fecal microbiota transplantation is used with success in persistent (more than two episodes) Clostridium Difficile Infection; it has also gained importance and started to be used in inflammatory bowel disease. There are theoretical arguments that justify its use in ulcerative colitis or Crohn’s disease. Based on our clinical cases we tried to evaluate the indications of fecal microbiota transplantation young patients with ulcerative colitis and multiple relapses, in which biological or immunosuppressive treatment were ineffective.Methods. Five patients with moderate-severe ulcerative colitis or Clostridium Difficile infection who ceased to have a therapeutic response to biological therapy, were given fecal microbiota transplant as an alternative to biological therapy and/or immunosuppression. Fecal microbiota transplant was administered via colonoscopy using healthy donors from their family.Results. The results were favorable and spectacular in all patients and complete remission was achieved for at least 10 months. Clinical remission was achieved in all patients. Endoscopic appearance of ulcers in patients improved. In 2 patients the effect of the fecal microbiota transplant diminished after 10-12 months and the tendency to relapse appeared (3-4 stools/day, blood streaks present sometimes in the stool). Reintroduction of systemic therapy or immunosuppression demonstrated that patients regained the therapeutic response to these treatments, and remission was maintained.Conclusion. Fecal microbiota transplantation can be used as salvage therapy in patients refractory to biological therapy, as elective therapy in clostridium difficile infection or as an alternative therapy in young patients with multiple relapses who have reservations regarding biological or immunosuppressive treatment.
The Register of the Qadi Court “Kiyahi Pĕqih Najmuddin” of the Sultanate of Banten, 1754-1756 CE.
Authors: Yakin Ayang Utriza 
Published: January 2016

The present study focuses on manuscript LOr 5626 from the archives of the Qadi of the Sultanate of Bantěn (1527-1813), in Indonesia. This codex is preserved in the Leiden University library, which acquired it from C. Snouck Hurgronje. It consists of the ‘legal cases’ brought before the Kiyahi Pěqih Najmuddin, the Islamic judge in Bantěn, by the inhabitants. The register, which covers the period from 1754 to 1756, is the oldest ‘sijill’ (court record) in Southeast Asia, and it contains cases on marriage, divorce, inheritance, litigation, private transactions, loans, debts, and violence. The manuscript demonstrates the judicial practice exercised by the qadi of Banten and reveals important findings on the relationship between Islamic legal theory and practice This essay hopefully will contribute to Islamic legal history in general both by providing textual evidence that the qadi record (sijill) existed in Southeast Asia during the eighteenth century and by presenting its contents.DOI: 10.15408/sdi.v22i3.2354
Changes in Pedagogical Interaction in the Context of Productive Learning
Authors: Petruškevičiūtė Auksė 
Published: January 2016

Productive Learning, an educational innovation in the education system of Lithuania, whose theoretical paradigms and methodology enable widening the scope of the concept of pedagogical interaction to the conceptual scope of educational interaction, is presented in this article. Social actors surrounding the young person, i.e. peer students, local community, various entities of the labour market, are being consistently involved into the process of his / her self-education. A student in cooperation with a teacher and other actors of the self-educational process design the self-education content that meets his / her individual needs, while the process of self-education of a student is integrated into the process of learning at sites of practical training that are selected by himself / herself.
Productive Learning is introduced as a “branch” of Alternative Education in Lithuania’s education system. Its target-group is students of Forms 9–10 who experience lasting failures at school and are attributed to the risk group of early school leavers.
In this article, changes at student, teacher and school level caused by the educational interaction taking place in the context of Productive Learning are discussed and the main impediments for building the educational interaction in the new environment are disclosed.
Building on the results of the empirical study that are corresponding those obtained in other countries (Germany, Finland) where Productive Learning is being adopted, an assertion can be made that the educational interaction being developed in Productive Learning leads to positive changes. Therefore, Productive Learning can be transferred and adopted in the education system of Lithuania as a feasible and effective pedagogical system.
The results and conclusions of the study bear relevance for education policymakers, researchers and practicians who are looking for new and effective possibilities for development of (self-) educational processes and those who conduct a deeper analysis of the phenomenon of educational interaction.
Descubrimientos estadunidenses de Cristóbal Colón
Authors: Handlin Lilian 
Published: January 2016

<p>Plantea las diferentes concepciones o imágenes que se han realizado sobre Cristóbal Colon en Estados Unidos, desde el periodo comprendido entre 1600 y 1750, cuando Colon fue prácticamente ignorado hasta la reconstrucción de su rostro, hacia fines del siglo XIX, cuando ya se había convertido primeramente en un símbolo y posteriormente en un icono. El año 1992 fue denominado por el Consejo Nacional de Iglesias "Año de oración y lamento por Colon".</p>
Supervivencia de la nobleza indígena en el siglo XVI
Authors: Pérez Zevallos Juan Manuel 
Published: January 2016

<p>Revisión histórica sobre el papel de la nobleza indígena a partir de la llegada de los españoles y la consiguiente ruptura del antiguo orden prehispánico; establece que a pesar de que logró un espacio dentro del aparato colonial, su poder se vio mermado. Subraya que "la decadencia del poder mexica [ ... ] también afectó a los señores particulares", principales y en general a toda la población indígena "que de una manera paulatina pero efectiva se vio arrinconada en el sistema colonial".</p>
La participación indígena en el abasto de la villa de Zamora, 1792
Authors: Silva Riquer Jorge 
Published: January 2016

<p>Se enfoca principalmente a la participación indígena en el mercado urbano de Zamora, Mich. en 1792, a partir de su producción agropecuaria, comercial y manufacturera. La producción no era muy variada, se concentraba en la manta, ocote, fruta y en ocasiones era controlada por un grupo reducido de comerciantes indígenas. Hace una descripción de la Ciénega y de la villa, explicando la composición étnica y social; analiza las valores y porcentajes de las mercancías en la región de Michoacán y particularmente de Zamora.</p>
Esclavitud o independencia: disyuntiva del liberalismo criollo oriental de la isla de Cuba en 1836
Authors: Portuondo Zúñiga Olga 
Published: January 2016

<p>Ensayo histórico sobre el liberalismo criollo en el departamento oriental de Cuba en 1836, encabezado por el liberal español Manuel Lorenzo, gobernador de dicho departamento, quien se enfrentó con el capitán general Miguel Tacón y Rosique. Se menciona el conflicto que Cuba, como colonia española, tuvo con las potencias extranjeras que habían invertido sus capitales en el ramo de agricultura, industria y comercio.</p>
Entrevista a Enrique Tandeter
Authors: Marichal Carlos 
Published: January 2016

<p>Exposición de las hipótesis principales del libro Coacción y mercado... de Enrique Tandeter, que versan sobre la minería del Potosí. Analiza las relaciones intercoloniales que generaron fuentes dispersas sobre el tema. Va­ lora el estudio de los precios y las alcabalas. Critica los estudios comparativos y afirma que todas las regiones eran parte del mismo reino y así deben estudiarse, como una unidad territorial.</p>
DISKURSUS ISLAM DALAM KONSTRUKSI MEDIA DI INDONESIA
Authors: Fahmi Muhammad , Abdullah Irwan , Noviani Ratna , Udasmoro Wening 
Published: January 2016

<p>This paper aims to examine how the secular media in Surakarta represent Islam in the case of Charlie Hebdo. Therefore, this study used discourse analysis of Theo van Leeuwen focusing on how the subject or actor of the show in the media. This study concluded that the media represent Islam not only with “Western ideology” through idioms such as radical Islamist militants and terrorists, but also with "Islamic ideology". It is done through the construction of Islam as a religion of moderation and delegitimize Charlie Hebdo as magazine satyr abusing freedom. Various strategies are used ranging from strategy passivation to interdetermination. In this case, there are two poles of attraction in both media, namely the Western and Islamic ideology. If both media are quoting from Western sources, the Western ideology dominates the media narrative. Conversely, when both media used Islamic sources, the influence of Islamic ideology dominates the narrative of both media.</p><p> </p>
The Relationship Between Social Justice and Clinical Legal Education: A Case Study of The Women’s Law Clinic, Faculty of Law, University of Ibadan, Nigeria
Authors: Byron Ibijoke Patricia 
Published: January 2016

<p>There is a vital connection between legal education, public interest and social justice because lawyers use their education for the benefit of the society. They render their services to those who are unable to afford legal services and in addition, challenge injustice under the justice system. Law students are trained by utilizing the techniques of clinical legal education and they are imbued with a social and professional responsibility to pursue social justice in society.</p><p>Much of the literature which propounds clinical methodologies in legal education implicitly understands that exposure to a social justice mission within a guided practice setting provides students not only with a key linkage between their legal education and their practice competence, but also with the intellectual foundation for a long-term engagement with the advancement of social justice.</p><p>The proponents of a social justice dimension and clinical legal education often refer to the “dual goals of hands-on-training in lawyering skills and provision of access to justice for traditionally unrepresented clients”.</p><p>This paper seeks to explore the relationship between clinical legal education and social justice using the Women’s Law Clinic in the University of Ibadan, Nigeria as an illustration.</p><p> </p>
Meeting the Required Reforms in Legal Education in Nigeria: Clinical Legal Education – Ten Years After
Authors: Adekoya Charles Olufemi 
Published: January 2016

<p>In many parts of the world, including Nigeria, legal education systems have been severely criticized both by stakeholders and consumers for being deficient in many respects in preparing “future lawyers, with many failing to provide the core competence necessary to practice law after a university education.” A global review has indicated that legal education systems are generally inadequate and needs to be improved upon. Also, a series of discussions at both international and regional levels have emphasized the need for transition in legal training in order to enhance its effectiveness. Legal education systems around the world have been under surveillance for failing to produce students who possess problem solving abilities, and the skills and values required<br />for the profession. In Nigeria, as it is in other jurisdictions, criticisms against legal education by stakeholders and consumers are severe, focusing on the quality of training, which is regarded as inadequate.</p><p>For these and other reasons, critics have called for reforms in legal education in Nigeria.</p><p>Based on the above, this paper attempts to examine the legal education deficits in Nigeria requiring reforms, and how clinical legal education (hereinafter called “CLE”) introduced in Nigeria in 2003, ten years ago, best meets the required reforms, the challenges confronting the practice and institutionalization of clinical education, towards the objective of having a legal education which inculcates knowledge, skills and values, and is more practice oriented. This paper is divided into five parts, Part II examines the introduction in Nigeria; Part III discusses the capability of CLE to meet the required reforms in legal education in Nigeria; Part IV examines the achievements, and challenges confronting the practice, mainstreaming and institutionalization of CLE in law faculties and the law school, and an evaluation of CLE; while Part V captures the conclusion and recommendations.</p>
Assessing Law clinic – the use of digital patch text assessment as an alternative to traditional portfolios
Authors: Clubb Karen 
Published: January 2016

<p>The paper presents the use of ‘patch text assessment’ as an innovative assessment method being ‘a series of integrated patch text assessments which are ‘stitched’ together with a final ‘patch’ to form a complete coherent piece of work. Each patch adds to the overall assessment.’ The use of patch text assessment is presented within the context of a year long research project which aimed to assess the use of digital media to enhance the use of patch text assessment within a law clinic module in UK Law School. This paper presents a brief outline of the context of clinical legal education in relation to its application within the Derby law clinic module, outlining the current influences within the field of higher education that guide the assessment process and context. The paper then briefly defines ‘traditional’ portfolios and the concept of patch text assessment before considering these each in turn more fully in relation to their advantages and disadvantages in terms of assessment strategy. The paper then progresses to outline the objectives of the research project and the methodology applied to achieve these. This is followed by an analysis of the project findings to conclude as to the effectiveness of digital media to enhance the use of patch text assessment and any benefits derived from this approach in comparison with ‘traditional’ portfolios for assessment.</p>
Washing Machines in Europe – Detailed Assessment of Consumption and Performance
Authors: Stamminger Rainer , Schmitz Angelika 
Published: January 2016

Abstract
Washing machines in Europe have to comply with regulations fixed in the Energy Label and Ecodesign legislation. They require declaration of the specific consumption and performance values which are deduced as average values from tests on three different treatments. Detailed data about the individual tests are normally not available to the public but just kept in the technical documentation of the manufacturer. Within the ATLETE II project 62 washing machines were measured to verify their compliance with the declared value. As this was an EU funded project all data are now also publicly available. This set of detailed measured data was used first to get a deeper inside into the performances and consumption values of the specific parameters and second to see how different the approaches are between manufacturers to achieve the same or similar declaration values. Additionally it could be shown that there are significant differences between those programmes used for the declaration and those offered as “normal” programmes to the consumer.
Improving sales turnover in fashion retailing by means of an RFID-based replenishment policy
Authors: Bottani Eleonora , Montanari Roberto , Romagnoli Giovanni 
Published: January 2016

In this paper, we aim to provide evidence of the capability to generate an increase in sales turnover by implementing an RFID-based system able to improve the shelf replenishment operations, reducing stock-out situations in fashion retailing. To evaluate the increase in sales turnover, we developed a pilot project involving a store of a major fashion firm located in northern Italy. RFID technology was used to generate daily a list of models that turned out to be available in the backroom, but not on the shelves (referred to as “scandals”), to drive employees in the replenishment process. By subsequently monitoring the consumer’s purchase, we estimated the contribution of RFID technology to the store turnover. We found that increasing the availability of products (and of scandals in particular) on the shelves leads to a significant increase in the sales volume. Moreover, the availability of those products on the shelves stimulates the customers to ask for different sizes or colours of the items exposed, generating further potential for sales increase. The results of this study may encourage fashion retailers to invest in RFID technology, whose cost often appears as high, since the increase in turnover can significantly contribute to recover the initial investment required. Also, since we carried out an in-field implementation, targeting a real scenario of the fashion industry, our results are realistic, solid and reliable. Fashion retailers can look at them as a concrete possibility to improve their business by adopting RFID technology.