bluuebunny/crossref_metadata_2025_split huggingface dataset:
AVANÇOS CURRICULARES NA FORMAÇÃO INICIAL DE PROFESSORES
Authors: Keller-Franco Elize , Masetto Marcos Tarciso 
Published: July 2017

As questões que se colocam para educação básica brasileira têm direcionado o olhar para os cursos de formação inicial de professores, sugerindo uma ressignificação dos conhecimentos e das práticas vigentes nesses cursos. Começa a emergir a compreensão de que as intervenções que tornam possível a inovação nos cursos de formação envolve a busca de novas abordagens curriculares que rompam com o paradigma curricular tradicional. O presente estudo traz para reflexão a análise crítica de uma organização curricular alternativa em andamento nas Licenciaturas da Universidade Federal do Paraná-Litoral, tendo como objetivo investigar em que medida a proposta que vem sendo desenvolvida nessa instituição traz elementos com potencial de contribuição para um novo paradigma curricular na formação inicial de professores. Adota-se como caminho metodológico um estudo exploratório de abordagem qualitativa. Para obtenção dos dados, privilegiou-se a análise documental. Os resultados indicam que o currículo em andamento traz novos contornos para o campo da teoria e das práticas curriculares dos programas de formação de professores. Ao colocar em ação os princípios de uma educação emancipatória e de uma proposta pedagógica fundamentada em projetos, o currículo rompe com o paradigma técnico disciplinar e identifica-se com as teorias curriculares críticas e pós-críticas e com a abordagem do currículo integrado. O caráter de construção em movimento do currículo, aberto para que a inteligência coletiva dos educadores em seus contextos institucionais encontre espaço para a diversificação e a inovação, coloca-se diante da possibilidade de um novo paradigma em processo.
Ultrastructure of the spermatozoon of Macvicaria obovata (Digenea: Opecoelidae), a parasite of Sparus aurata(Pisces: Teleostei) from the Gulf of Gabès, Mediterranean Sea
Authors: Kacem Hichem , Quilichini Yann , Neifar Lassad , Torres Jordi , Miquel Jordi 
Published: July 2017

AbstractThe ultrastructural organization of the spermatozoon of the digenean
Durettenema guangdongense gen. et sp. nov. (Nematoda: Molineoidea) from Hipposideros larvatus (Horsfield) (Chiroptera: Rhinolophidae) with discussion of the taxonomic status of Macielia rhinolophi Yin, 1980
Authors: Ju Hui-Dong , Li Liang , Zhang Lu-Ping 
Published: July 2017

Abstractgen. et sp. nov. is described from
Comparison Between the Economic-Statistical Design of Double and Triple Sampling X¯\bar{X} Control Charts
Authors: Iziy Azamsadat , Sadeghpour Gildeh Bahram , Monabbati Ehsan 
Published: July 2017

Abstract
Control charts have been established as major tools for quality control and improvement in industry. Therefore, it is always required to consider an appropriate design of a control chart from an economical point of view before using the chart.
The economic design of a control chart refers to the determination of three optimal control chart parameters: sample size, the sampling interval, and the control limits coefficient.
In this article, the double sampling (DS)

X
¯

{\bar{X}}

control chart is considered for the
economic design using nonlinear mixed integer programming approach. The triple sampling (TS)

X
¯

{\bar{X}}

control charts are developed for economic design based on the results of solving the DS

X
¯

{\bar{X}}

chart design problems.
In this model, we assume that the process must be shut down during the search for the assignable cause.
Multiple sampling

X
¯

{\bar{X}}

charts can be designed for quick detection of a small shift in process.
The results of the comparison between the economic-statistical design of DS and TS

X
¯

{\bar{X}}

control charts show that TS

X
¯

{\bar{X}}

control charts are more efficient in terms of minimizing the average sample size, but its expected average cost takes larger values.
Conceptual roots for innovation and innovativeness of the economy in Poland
Authors: Strahl Danuta , Sobczak Roman 
Published: July 2017

Abstract
The purpose of the article is to provide the evolutionary review and systemization of the basic concepts related to innovation and innovativeness in Polish research on regional economics and development. The emphasis is placed on the types of innovation and innovativeness of the economy and the main conceptual and practical sources for the innovation and innovativeness concept are being discussed within the framework of European regional policy.
Looks can be deceiving: body image dissatisfaction relates to social anxiety through fear of negative evaluation
Authors: Pawijit Yada , Likhitsuwan Watcharaphon , Ludington Jason , Pisitsungkagarn Kullaya 
Published: July 2017

Abstract

Introduction
Emerging adults are particularly vulnerable to body image dissatisfaction and social anxiety. These bring about a host of negative outcomes, including compromised social adjustment and well-being. Fear of negative evaluation has been shown to be a core element of social anxiety, but it is rarely considered in studies of body image and its effects on social anxiety. This study aimed to bridge this gap by examining the role of fear of negative evaluation in the association between body image dissatisfaction and social anxiety.

Methods
A cross-sectional study using 80 Thai undergraduates (mean age of 21 years) was conducted by self-reported (questionnaire) measures. Body image dissatisfaction was measured with the short version of the Body Shape Questionnaire (BSQ-8C), fear of negative evaluation with the Brief Fear of Negative Evaluation Scale, and social anxiety with the Interaction Anxiousness Scale (IAS). Correlation and mediation analyses were conducted to assess how these constructs were related to one another.

Results
The key hypothesis was supported: positive associations were found among body image dissatisfaction, fear of negative evaluation and social anxiety, and the association between body image dissatisfaction and social anxiety was mediated by fear of negative evaluation.

Discussion
Generalizing from the current findings, ideas for possible amelioration of social anxiety are discussed.
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature
Authors: Bustamante Carmen , Hoyos-Martínez Alfonso , Pirela Daniela , Díaz Alejandro 
Published: July 2017

AbstractBackground:Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). High maternal androgens can cross the placenta producing virilization of the female fetus.Case presentation:A 46,XX newborn female, whose mother was diagnosed with a metastatic ovarian tumor during her second trimester of gestation associated with worsening hirsutism and acne, was found to have ambiguous genitalia at birth. Testosterone levels in both the mother and infant were elevated. Follow-up laboratory tests showed progressive normalization of circulating androgens after delivery.Conclusions:Krukenberg tumors are rare and may produce virilization of the mother and the female fetus when present during pregnancy.
Effects of Wearing a Compression Garment During Night Sleep on Recovery From High-Intensity Eccentric-Concentric Quadriceps Muscle Fatigue
Authors: Shimokochi Yohei , Kuwano Satoshi , Yamaguchi Taichi , Abutani Hiroyuki , Shima Norihiro 
Published: July 2017

Abstract
Shimokochi, Y, Kuwano, S, Yamaguchi, T, Abutani, H, and Shima, N. Effects of wearing a compression garment during night sleep on recovery from high-intensity eccentric-concentric quadriceps muscle fatigue. J Strength Cond Res 31(10): 2816–2824, 2017—This study aimed to investigate the effects of wearing a compression garment (CG) during night sleep on muscle fatigue recovery after high-intensity eccentric and concentric knee extensor exercises. Seventeen male college students participated in 2 experimental sessions under CG and non-CG (NCG) wearing conditions. Before night sleep under CG or NCG wearing conditions, the subjects performed a fatiguing protocol consisting of 10 sets of 10 repetitions of maximal isokinetic eccentric and concentric knee extensor contractions, with 30-second rest intervals between the sets. Immediately before and after and 24 hours after the fatiguing protocol, maximum voluntary isometric contraction (MVIC) force for knee extensor muscles was measured; surface electromyographic data from the vastus medialis and rectus femoris were also measured. A 2-way repeated-measure analysis of variance followed by Bonferroni pairwise comparisons were used to analyze the differences in each variable. Paired-sample t-tests were used to analyze the mean differences between the conditions at the same time points for each variable. The MVIC 24 hours after the fatiguing protocol was approximately 10% greater in the CG than in the NCG condition (p = 0.033). Changes in the electromyographic variables over time did not significantly differ between the conditions. Thus, it was concluded that wearing a CG during night sleep may promote localized muscle fatigue recovery but does not influence neurological factors after the fatiguing exercise.
Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome
Authors: Boudaoud Imène , Fournier Éric , Baguette Audrey , Vallée Maxime , Lamaze Fabien C , Droit Arnaud , Bilodeau Steve 
Published: July 2017

Abstract
Cornelia de Lange syndrome (CdLS) is a complex multisystem developmental disorder caused by mutations in cohesin subunits and regulators. While its precise molecular mechanisms are not well defined, they point toward a global deregulation of the transcriptional gene expression program. Cohesin is associated with the boundaries of chromosome domains and with enhancer and promoter regions connecting the three-dimensional genome organization with transcriptional regulation. Here, we show that connected gene communities, structures emerging from the interactions of noncoding regulatory elements and genes in the three-dimensional chromosomal space, provide a molecular explanation for the pathoetiology of CdLS associated with mutations in the cohesin-loading factor NIPBL and the cohesin subunit SMC1A. NIPBL and cohesin are important constituents of connected gene communities that are centrally positioned at noncoding regulatory elements. Accordingly, genes deregulated in CdLS are positioned within reach of NIPBL- and cohesin-occupied regions through promoter–promoter interactions. Our findings suggest a dynamic model where NIPBL loads cohesin to connect genes in communities, offering an explanation for the gene expression deregulation in the CdLS.
Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department
Authors: Irwin Adam D. , Grant Alison , Williams Rhian , Kolamunnage-Dona Ruwanthi , Drew Richard J. , Paulus Stephane , Jeffers Graham , Williams Kim , Breen Rachel , Preston Jennifer , Appelbe Duncan , Chesters Christine , Newland Paul , Marzouk Omnia , McNamara Paul S. , Diggle Peter J. , Carrol Enitan D. 
Published: July 2017

BACKGROUND:
Improving the diagnosis of serious bacterial infections (SBIs) in the children’s emergency department is a clinical priority. Early recognition reduces morbidity and mortality, and supporting clinicians in ruling out SBIs may limit unnecessary admissions and antibiotic use.

METHODS:
A prospective, diagnostic accuracy study of clinical and biomarker variables in the diagnosis of SBIs (pneumonia or other SBI) in febrile children &lt;16 years old. A diagnostic model was derived by using multinomial logistic regression and internally validated. External validation of a published model was undertaken, followed by model updating and extension by the inclusion of procalcitonin and resistin.

RESULTS:
There were 1101 children studied, of whom 264 had an SBI. A diagnostic model discriminated well between pneumonia and no SBI (concordance statistic 0.84, 95% confidence interval 0.78–0.90) and between other SBIs and no SBI (0.77, 95% confidence interval 0.71–0.83) on internal validation. A published model discriminated well on external validation. Model updating yielded good calibration with good performance at both high-risk (positive likelihood ratios: 6.46 and 5.13 for pneumonia and other SBI, respectively) and low-risk (negative likelihood ratios: 0.16 and 0.13, respectively) thresholds. Extending the model with procalcitonin and resistin yielded improvements in discrimination.

CONCLUSIONS:
Diagnostic models discriminated well between pneumonia, other SBIs, and no SBI in febrile children in the emergency department. Improvements in the classification of nonevents have the potential to reduce unnecessary hospital admissions and improve antibiotic prescribing. The benefits of this improved risk prediction should be further evaluated in robust impact studies.
Da’i Muda Pilihan (DMP) ANTV dalam Perspektif Dakwah
Authors: Fatmawati Fatmawati 
Published: July 2017

This paper attempts to unravel the involvement of media in orbit would be preachers and da'iah as a television program. The position of television as a medium to be very important in clarifying the boundaries of da'iah professionalism because a preacher or items related to the assessment standards applied by the media as an organizer of the contest. In addition, this paper also presents the phenomenon of young preachers that the selection program is a form of positive cooperation between the Islamic syi'ar the media so that the message of Islam can exist in the development of information and communication technology is rapidly increasing.
Endogenous Heat-Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma
Authors: Domingo-Musibay Evidio , Heun James M. , Nevala Wendy K. , Callstrom Matthew , Atwell Thomas , Galanis Evanthia , Erickson Lori A. , Markovic Svetomir N. 
Published: July 2017

Abstract

Lessons Learned
Percutaneous thermal ablation combined with in situ granulocyte-macrophage colony-stimulating factor cytokine therapy was technically feasible and well tolerated. No significant clinical or immunologic responses were seen.

Background
Melanoma tumor-derived heat-shock proteins (HSPs) and HSP-peptide complexes can elicit protective antitumor responses. The granulocyte-macrophage colony-stimulating factor (GM-CSF) chemokine can also promote uptake and processing by professional antigen presenting cells (APCs). On this basis, we designed a pilot study of percutaneous thermal ablation as a means to induce heat-shock protein vaccination plus GM-CSF to determine safety and preliminary antitumor activity of this combination.

Materials and Methods
This study was designed to assess overall safety of percutaneous ablation combined with GM-CSF for unresectable, metastatic melanoma including uveal and mucosal types. All patients received heat-shock therapy (42°C for 30 minutes), then received one of three treatments: (a) intralesional GM-CSF (500 mcg standard dose); (b) radiofrequency ablation (RFA) + GM-CSF; or (c) cryoablation plus GM-CSF. The primary endpoint of the study was the induction of endogenous HSP70 and melanoma-specific cytotoxic T lymphocytes (CTL).

Results
Nine patients (three per study arm) were enrolled. No dose-limiting toxicity was observed as specified per protocol. All patients developed progressive disease and went on to receive alternative therapy. Median overall survival (OS) was 8.2 months (95% confidence interval [CI] 2–17.2). The study was not powered to detect a difference in clinical outcome among treatment groups.

Conclusion
Percutaneous thermal ablation plus GM-CSF was well tolerated, technically feasible, and demonstrated an acceptable adverse event profile comparable to conventional RFA and cryoablation. While HSP70 was induced following therapy, the degree of HSP70 elevation was not associated with clinical outcome or induced CTL responses. While percutaneous thermal ablation plus GM-CSF combinations including checkpoint inhibitors could be considered in future studies, the use of GM-CSF remains experimental and for use in the context of clinical trials.
Assessment of rainwater harvesting tank size for livestock use
Authors: Londra P. A. , Theocharis A. T. , Baltas E. , Tsihrintzis V. A. 
Published: July 2017

Abstract
Rainwater harvesting is an ancient practice aiming to cover water needs for domestic, irrigation and livestock uses. In this study, the rainwater harvesting tank size was investigated to meet five water-need levels of a mixed goat–sheep farm using a daily water balance method. This method was applied using daily rainfall data for a period of 16 years from six meteorological stations in selected regions of Greece, characterized by different rainfall regimes and well-developed livestock activity, taking into account, among other parameters, the water needs of animals, the rainwater collection area and the runoff coefficient. There is a great variation in the rainwater harvesting tank size among the stations studied due to differences in the annual rainfall and the maximum dry period. Results showed that meeting full demands (100% reliability) requires tank sizes ranging from 20 m3 for short dry period stations–low demand scenario (320 L/day) to 115 m3 for long dry period stations–high demand scenario (576 L/day), assuming a maximum collection area of 450 m2. Correspondingly, reliability analysis showed that very high values of reliability (95%) can be obtained with tank sizes ranging from 10 to 85 m3, respectively.
Non-genetic effects on growth characteristics of Brahman cattle
Authors: Hernández-Hernández Nicacia , Martínez-González Juan , Parra-racamonte Gaspar , Ibarra-Hinojosa Martín , Briones-Encinia Florencio , Saldaña-Campos Pánfilo , Ortega-Rivas Eligio 
Published: July 2017

Objective. To determine how some non-genetic factors influence weights at birth (BW), weaning (WW) and yearling (YW) of Brahman calves. Materials and methods. Data corresponding to 58257, 57045 and 40364 for BW, WW and YW, respectively, were analyzed. The models included the effects of year and season of birth and sex, and were considered simple interactions. Results. All effects were significant (p<0.05) for BW, WW and YW. Only the season of birth didn’t have a significant effect (p>0.05) on WW. The average general BW, WW and YW were 32±3.2, 188±37.7 and 291±56.8 kg, respectively. Variables evaluated that take into account the year of birth show a trend to increase weight each year. In relation to the birth season on BW and YW, it was observed that calves born during the rainy season were heavier than those born during the dry season. Similarly, male calves were heavier than females at birth, weaning and one year of age. The effects of the analyzed interactions were significant (p<0.05) for the three variables, except for the season of birth per sex interaction, which did not have a significant effect (p>0.05) for BW and WW. Conclusions. The studied non-genetic factors were important and should be taken into account in management strategies when striving to increase the efficiency of the productive system. Key words: Zebu, birth weight, weaning weight, year weight. (Source: AIMS)
The oncologic burden of hepatitis C virus infection: A clinical perspective
Authors: Torres Harrys A. , Shigle Terri Lynn , Hammoudi Nassim , Link James T. , Samaniego Felipe , Kaseb Ahmed , Mallet Vincent 
Published: July 2017

ABSTRACTAnswer questions and earn CME/CNEChronic hepatitis C virus (HCV) infection affects millions of people worldwide and is associated with cancer. Direct‐acting antivirals (DAAs) have changed HCV treatment paradigms, but little is known about the management of HCV infection in patients with cancer. The substantial burden of HCV infection and the inconclusive evidence regarding its detection and management in patients with cancer prompted the authors to review the literature and formulate recommendations. Patients for whom HCV screening is recommended included all patients with hematologic malignancies, hematopoietic cell transplantation candidates, and patients with liver cancer. There is a lack of consensus‐based recommendations for the identification of HCV‐infected patients with other types of cancer, but physicians may at least consider screening patients who belong to groups at heightened risk of HCV infection, including those born during 1945 through 1965 and those at high risk for infection. Patients with evidence of HCV infection should be assessed by an expert to evaluate liver disease severity, comorbidities associated with HCV infection, and treatment opportunities. DAA therapy should be tailored on the basis of patient prognosis, type of cancer, cancer treatment plan, and hepatic and virologic parameters. HCV‐infected patients with cancer who have cirrhosis (or even advanced fibrosis) and those at risk for liver disease progression, especially patients with HCV‐associated comorbidities, should have ongoing follow‐up, regardless of whether there is a sustained virologic response, to ensure timely detection and treatment of hepatocellular carcinoma. HCV infection and its treatment should not be considered contraindications to cancer treatment and should not delay the initiation of an urgent cancer therapy. CA Cancer J Clin 2017. © 2017 American Cancer Society. CA Cancer J Clin 2017;67:411–431. © 2017 American Cancer Society.
Near-infrared Spectroscopic Observations of Comet C/2013 R1 (Lovejoy) by WINERED: CN Red-system Band Emission
Authors: Shinnaka Yoshiharu , Kawakita Hideyo , Kondo Sohei , Ikeda Yuji , Kobayashi Naoto , Hamano Satoshi , Sameshima Hiroaki , Fukue Kei , Matsunaga Noriyuki , Yasui Chikako , Izumi Natsuko , Mizumoto Misaki , Otsubo Shogo , Takenaka Keiichi , Watase Ayaka , Kawanishi Takafumi , Nakanishi Kenshi , Nakaoka Tetsuya 
Published: July 2017

Abstract
Although high-resolution spectra of the CN red-system band are considered useful in cometary sciences, e.g., in the study of isotopic ratios of carbon and nitrogen in cometary volatiles, there have been few reports to date due to the lack of high-resolution (R ≡ λ/Δλ > 20,000) spectrographs in the near-infrared region around ∼1 μm. Here, we present the high-resolution emission spectrum of the CN red-system band in comet C/2013 R1 (Lovejoy), acquired by the near-infrared high-resolution spectrograph WINERED mounted on the 1.3 m Araki telescope at the Koyama Astronomical Observatory, Kyoto, Japan. We applied our fluorescence excitation models for CN, based on modern spectroscopic studies, to the observed spectrum of comet C/2013 R1 (Lovejoy) to search for CN isotopologues (13C14N and 12C15N). We used a CN fluorescence excitation model involving both a “pure” fluorescence excitation model for the outer coma and a “fully collisional” fluorescence excitation model for the inner coma region. Our emission model could reproduce the observed 12C14N red-system band of comet C/2013 R1 (Lovejoy). The derived mixing ratio between the two excitation models was 0.94(+0.02/−0.03):0.06(+0.03/−0.02), corresponding to the radius of the collision-dominant region of ∼800–1600 km from the nucleus. No isotopologues were detected. The observed spectrum is consistent, within error, with previous estimates in comets of 12C/13C (∼90) and 14N/15N (∼150).