bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemosensory function of Varroa gnathosoma: transcriptomic and proteomic analyses
Authors: Nganso Beatrice T. , Eliash Nurit , Mani Kannan , Sela Noa , Villar-Briones Alejandro , Osabutey Angelina Fathia , Rafaeli Ada , Mikheyev Alexander S. , Soroker Victoria 
Published: October 2024

AbstractIn this study, we evaluated the role of the gnathosoma (mouthparts) in chemosensing of the most devastating honey bee parasite, Varroa destructor mite. Through transcriptomic analysis, we compared the expression of putative chemosensory genes between the body parts containing the main chemosensory organs (the forelegs), gnathosoma and the rest of the body devoid of these two body parts. Furthermore, we checked the presence of chemosensory-related transcripts in the proteome of the gnathosoma. Our comparative transcriptomic analysis revealed the presence of 83 transcripts with known characteristic conserved domains belonging to eight chemosensory gene families in the three Varroa transcriptomes. Among these transcripts, 11 were significantly upregulated in the mite’s forelegs, compared to 8 and 10 in the gnathosoma and body devoid of both organs, respectively. Whilst the gnathosoma and the forelegs share similar expression of some putative lipid carrier proteins, membrane-bound receptors, and associated proteins, they also differ in the expression profiles of some transcripts belonging to these protein families. This suggests two functional chemosensory organs that may differ in their chemosensory function according to specific characteristics of compounds they detect. Moreover, the higher expression of some chemosensory transcripts in the body devoid of forelegs and gnathosoma compared to the gnathosoma alone, may suggest the presence of additional function of these transcripts or alternatively presence of additional external or internal chemosensory organs. Insights into the functional annotation of a highly expressed gustatory receptor present in both organs using RNA interference (RNAi) are also revealed.
Quantum search algorithm for binary constant weight codes
Authors: Yukiyoshi Kein , Ishikawa Naoki 
Published: October 2024

AbstractA binary constant weight code is a type of error-correcting code with a wide range of applications. The problem of finding a binary constant weight code has long been studied as a combinatorial optimization problem in coding theory. In this paper, we propose a quantum search algorithm for binary constant weight codes. Specifically, the search problem is formulated as a polynomial binary optimization problem and Grover adaptive search is used for providing the quadratic speedup. Focusing on the inherent structure of the problem, we derive an upper bound on the minimum of the objective function value and a lower bound on the exact number of solutions. By exploiting these two bounds, we successfully reduced the constant overhead of the algorithm, although the overall query complexity remains exponential due to the NP-complete nature of the problem. In our algebraic analysis, it was found that this proposed algorithm is capable of reducing the number of required qubits, thus enhancing the feasibility. Additionally, our simulations demonstrated that it reduces the average number of classical iterations by 63% as well as the average number of total Grover rotations by 31%. The proposed approach may be useful for other quantum search algorithms and optimization problems.
Documenting the First Three U.S. Aircraft Discovered in Truk Lagoon from Operation Hailstone (February, 1944)
Authors: Moline Mark A. , Colbourn Colin , Pietruszka Andrew , Davis Dan , White Erik , Breece Mathew W. , Character Leila , Terrill Eric , Hess Robert 
Published: October 2024

AbstractOperation Hailstone, conducted on 17–18 February 1944, was a major battle between the United States fast carrier Task Force 58 against the forward operating naval base of the Imperial Japanese Navy at Truk Lagoon (modern-day Chuuk, Federated States of Micronesia). The battle saw devastating losses for the Japanese forces with over 4500 casualties, over 50 ships sunk and over 250 planes lost. Because the battle losses were so skewed, the United States losses are often understated or overlooked. Thirty-five U.S. service members were killed with as many as 17 aircraft lost, with further losses in subsequent attacks. Despite Truk Lagoon’s status as a premier dive destination since the mid-1960s, no American aircraft from this battle or subsequent raids on the Chuuk atoll have been located in the lagoon prior to the surveys reported here. In an effort to locate remains of American service members still missing in action from this battle (35 from Operation Hailstone and as many as 225 from subsequent attacks and bombing missions on the atoll), we applied both knowledge from historical archives and advanced underwater robotics to survey large sections of the lagoon for these lost aircraft. With over 75 km2 surveyed, we located three American aircraft lost in Truk Lagoon during Operation Hailstone; two Douglas SBD-5 Dauntlesses and either a Grumman TBF or TBM Avenger. Here, we document these sites and link each to the detailed historical accounts of their loss. Each of these aircraft is known to have been crewed by service members still missing in action. This work underscores the American losses during Operation Hailstone and sheds light on the more than 72,000 service members still missing in action from World War II.
Supply and Demand of Processed Potato Products in Kenya, Rwanda, and Uganda: Variety Requirements of Processing Companies and Implications for Trait Prioritization for Breeding
Authors: Naziri Diego , Devaux André , Hareau Guy , Wauters Pieter 
Published: October 2024

AbstractThe potato processing industry in Kenya, Rwanda, and Uganda is expanding rapidly. This study assesses the current situation and outlook of the local industrial potato processing sector and the alignment of the industry’s variety requirements with the priorities set by breeders. Currently, potato processing companies in the three countries use both varieties selected locally from public international germplasm and varieties introduced by Dutch seed companies, and their suitability for processing is discussed as well. Overall, the processing industry pays high attention to traits affecting processing efficiency and consumers’ acceptance while breeders, in spite of being aware of the characteristics required for processing varieties, are more focused on traits related to production and disease resistance. As the processing sector develops further, breeders will have to pay increased attention to the progressively stricter requirements of the industry, striking the right balance between farmers’ and processors’ variety requirements. While their opinions on the farmers’ acceptability of processing varieties diverge, breeders and industry agree about the challenges represented by the limited access to quality seed and poor business linkages between value chain actors in securing the supply of varieties suitable for processing. Based on these findings, it is recommended to pay more attention to both the development of dual-purpose varieties and the strengthening of the potato value chain through the improvement of business linkages between seed producers, farmers, and processing companies.
The essential role of combined calcium and vitamin D supplementation in the osteoporosis scenario in italy: Expert opinion paper
Authors: Carugo Stefano , Vescini Fabio , Giusti Andrea , Mauro Giulia Letizia , Tafaro Laura , Festuccia Francescaromana , Muraca Lucia , Menè Paolo , Rossini Maurizio 
Published: October 2024

Abstract
Summary
An Italian multidisciplinary working group discussed the current Italian scenario of osteoporosis management during a meeting and highlighted the essential role of calcium and vitamin D supplementation in the prevention of fragility fractures.

Purpose
This paper aims to review and discuss data on calcium and vitamin D requirements and the role of combined calcium and vitamin D supplementation in the treatment of patients with osteoporosis.

Methods
The discussion of the experts covered literature data on calcium and vitamin D supplementation, gaps in the diagnosis and treatment of osteoporosis, and the role of the primary care physician in identifying and treating patients with osteoporosis. Articles for consideration were identified through PubMed searches using different combinations of pertinent keywords.

Results
The discussion highlighted that insufficient calcium or vitamin D intake increases the risk of fragility fractures. The experts also drew attention to the essential role of calcium and vitamin D supplementation in achieving an anti-fracture effect and supporting the efficacy of anti-osteoporotic agents without increasing nephrolithiasis and cardiovascular risks. In addition, the discussion underlined the role of the primary care physician in the initial clinical approach to patients with osteoporosis.

Conclusions
The experts believe that efficient treatment for patients with osteoporosis should include calcium and vitamin D supplementation to achieve adequate levels that are able to inhibit the parathyroid hormone and bone resorption.
Risk of first hip fracture under treatment with zoledronic acid versus alendronate: a NOREPOS cohort study of 88,000 Norwegian men and women in outpatient care
Authors: Riska Brit Solvor Lyse , Gunnes Nina , Finnes Trine E. , Meyer Haakon E. , Hoff Mari , Omsland Tone K. , Holvik Kristin 
Published: October 2024

Abstract
Summary
We aimed to investigate the risk of hip fracture associated with zoledronic acid treatment compared to alendronate on a population level. The risk of hip fracture was lower in women using zoledronic acid and higher in women who had discontinued treatment. The findings support the effectiveness of intravenous bisphosphonate.

Purpose
To investigate whether zoledronic acid (ZOL) was associated with a lower risk of the first hip fracture than alendronate (ALN) in Norway using real-world data.

Methods
Nationwide data on drugs dispensed in outpatient pharmacies were individually linked with all hospital-treated hip fractures. Individuals aged 50–89 years without previous hip fracture were included at their first filling of a prescription for ALN or ZOL during 2005–2016. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) for first hip fracture by time-varying exposure to ZOL versus ALN were estimated in sex-stratified flexible parametric survival analyses. Covariates included time-varying accumulated ALN exposure and comorbidity level expressed by the prescription-based Rx-Risk Comorbidity Index, marital status, education, and residential urbanity.

Results
Of 75,250 women who initiated treatment, 72,614 (96.5%) were exposed to ALN and 6366 (8.5%) to ZOL. Of 12,739 men who initiated treatment, 12,311 (96.6%) were exposed to ALN and 784 (6.2%) to ZOL. In women, the HR for first hip fracture was 0.75 (95% CI: 0.61–0.91) for ZOL versus ALN. In men, the corresponding HR was 0.59 (95% CI: 0.32–1.07). Discontinued treatment was associated with increased risk compared with current ALN treatment in women (HR: 1.33; 95% CI: 1.24–1.42, men: HR 1.13 (95% CI: 0.95–1.35)).

Conclusions
In women, the risk of first hip fracture when treated with ZOL was 25% lower than when treated with ALN. Discontinued treatment was associated with a 33% increase in hip fracture risk. Similar, albeit statistically non-significant, results were observed in men.
Second-order strongly nonlinear impulsive coupled systems
Authors: Minhós Feliz , Rodrigues Gracino 
Published: October 2024

AbstractThis paper presents sufficient conditions for the solvability of a second-order coupled system, composed of two differential equations involving different laplacians applied to fully discontinuous nonlinearities, two-point boundary conditions, and generalized impulsive effects. Applying the lower and upper solutions technique and Schauder’s fixed point theorem, it is obtained an existence and localization theorem, based on local monotone properties on the nonlinearities and the impulsive functions.
Evolving Treatment Landscape for Advanced Esophageal and Gastroesophageal Junction Adenocarcinoma
Authors: Wheless Margaret C. , Comer Margaret , Gibson Michael K. 
Published: October 2024

Abstract
Purpose of Review
This review highlights advances and recent changes in the treatment paradigm for advanced esophageal adenocarcinoma (EAC) and gastroesophageal junction adenocarcinoma (GEJAC).

Recent Findings
Chemotherapy remains the backbone of treatment for advanced EAC/GEJAC. New targets/agents include immunotherapy, HER-2, claudin18.2, and FGFR2b, with various mechanisms (CAR-T, bispecific mAB, ADCs) altering the treatment landscape against these targets.

Summary
The approaches to these targets may act together, in sequence, and even synergistically to improve outcomes. Herein, we review the state of the field, including highlighting ongoing clinical trials and additional emerging agents and approaches.
Clinical outcomes after post-operative radiotherapy for breast cancer patients presenting with ipsilateral supraclavicular metastasis: considerations on the cranial border of irradiation field
Authors: Wang Xiaofang , Zhang Xiaomeng , Zhang Li , Meng Jin , Shi Wei , Chen Xingxing , Yang Zhaozhi , Mei Xin , Yu Xiaoli , Zhang Zhen , Shao Zhimin , Guo Xiaomao , Ma Jinli 
Published: October 2024

Abstract
Background
Disease recurrence at lower neck adjacent to ipsilateral supraclavicular (SCV) region represents a concern in locally advanced breast cancer patients presenting with SCV metastasis at diagnosis. This study aims to report the outcomes following post-operative radical radiation therapy and discuss the reasonable cranial border of the irradiation field for N3c patients.

Methods
Between July 2016 and January 2022, a total of 268 patients were eligible for analysis. The endpoints included in-field and out-field cervical failures, local–regional recurrence-free survival (LRRFS), SCV recurrence-free survival (SRFS), distant metastasis-free survival (DMFS), relapse-free survival (RFS), and overall survival (OS).

Results
During a median follow-up of 37 months (range 3–89 months), 17 patients (6.3%) developed local–regional recurrence as the first recurrence event, with 13 having concomitant distant-metastasis (DM); 56 patients (20.9%) had DM alone. The 3-year rates of LRRFS, SRF, DMFS, RFS, and OS were 92.3%, 94.5%, 74.5%, 73.0%, and 90.0%, respectively. 89.2% of patients received RT with the cranial border at the top of hyoid bone, and 95.1% of patients received a boost not exceeding the level of cricoid cartilage. A total of 11 patients (4.1%) developed ipsilateral SCV failure, and 3 patients (1.1%) experienced cervical failure, including 2 in-field failures and 1 out-field failure. Neoadjuvant systemic therapy (NST) was administered to 234 patients (87.3%). In the multivariate analysis, non-ypN0, triple-negative subtype and cT4 at diagnosis were predictors of worse SRFS and RFS in NST subgroup.

Conclusion
Our findings suggest that radical RT with cranial border of irradiation field at the hyoid bone level lead to excellent local–regional control, and out-field cervical failure was rare. The irradiation field might not extend to mastoid process.
Overexpression of a disintegrin and metalloproteinase 9 (ADAM9) in relation to poor prognosis of patients with oral squamous cell carcinoma
Authors: Wu Shuangjiang , Cheng Lang , Luo Tao , Makeudom Anupong , Wang Lei , Krisanaprakornkit Suttichai 
Published: October 2024

AbstractThis study investigates the expressions of ADAM9, CDCP1 and t-PA in OSCC and their impacts on patient prognosis. Previous research has demonstrated the overexpression of ADAM9 and activation of plasminogen activator in OSCC, but CDCP1's role remains unexplored. While these biomolecules are known to contribute to lung cancer metastasis, their concurrent expressions in OSCC have not been thoroughly examined. Our aim is to assess the expressions of ADAM9, CDCP1, and t-PA in OSCC specimens, compare them with normal oral tissues, and explore their correlation with OSCC's clinicopathological features and patient survival outcomes.
Skin feature point tracking using deep feature encodings
Authors: Chang Jose Ramon , Nordling Torbjörn E. M. 
Published: October 2024

AbstractFacial feature tracking is a key component of imaging ballistocardiography (BCG) where accurate quantification of the displacement of facial keypoints is needed for good heart rate estimation. Skin feature tracking enables video-based quantification of motor degradation in Parkinson’s disease. While traditional computer vision algorithms like Scale Invariant Feature Transform (SIFT), Speeded-Up Robust Features (SURF), and Lucas-Kanade method (LK) have been benchmarks due to their efficiency and accuracy, they often struggle with challenges like affine transformations and changes in illumination. In response, we propose a pipeline for feature tracking, that applies a convolutional stacked autoencoder to identify the most similar crop in an image to a reference crop containing the feature of interest. The autoencoder learns to represent image crops into deep feature encodings specific to the object category it is trained upon. We train the autoencoder on facial images and validate its ability to track skin features in general using manually labelled face and hand videos of small and large motion recorded in our lab. Our evaluation protocol is comprehensive, including quantification of errors in human annotation. The tracking errors of distinctive skin features (moles) are so small that we cannot exclude the fact that they stem from the manual labelling based on a $$\chi ^2$$

χ
2

-test. With a mean error of 0.6–3.3 pixels, our method outperformed the other methods in all but one scenario. More importantly, our method was the only one that did not diverge. We also compare our method with the latest state-of-the-art transformer for feature matching by Google—Omnimotion. Our results indicate that our method is superior at tracking different skin features under large motion conditions and that it creates better feature descriptors for tracking, matching, and image registration compared to both traditional algorithms and the latest Omnimotion.
Improving Patient Understanding and Outcomes in Lung Cancer Using an Animated Patient’s Guide with Visual Formats of Learning
Authors: Patel Manish R. , Begnaud Abbie , Blackmon Shanda H. , Dudek Arkadiusz Z. , Fujioka Naomi , Harewood Janine C. K. , Jänne Pasi A. , Kern Shirley , Hawk Lacey Running , Rusk Ann M. , Wilder Fatima G. , Winn Robert , Torrison Nancy , Searle Stephanie 
Published: October 2024

AbstractLung cancer patient education resources that address barriers to health literacy, improve understanding, and demonstrate improved patient outcomes are limited. Our study aim was to evaluate and report on learner knowledge improvement and intent to implement behavior change, and validate the benefits of the You and Lung Cancer website and YouTube resources. Our study occurred from November 2017 to December 2023. We evaluated audience reach (visit sessions, unique visitors, country origins, page views) and calculated top views by media type (animations, expert videos, patient videos). We assessed the impact and commitment to change through learner surveys (areas of interest, intention to modify behaviors, and intention to discuss disease management with providers) and tested the knowledge of learners pre- and post-reviewing of website content. Our program reached 794,203 views globally; 467,546 were unique visitors; and 243,124 (51%) were unique visitors from the USA. Of US visitors, 46% identified as lung cancer patients. These were patients in treatment (38%), survivors (8%), family members or caregivers (21%), and healthcare providers (14%) with other audiences unspecified (19%). Three areas of highest learner importance were the animations “Understanding Non-Small Cell Lung Cancer” (180,591), “Staging of Lung Cancer” (144,238), and “Treatment and Management of Small Cell Lung Cancer” (49,244). Our study confirmed areas of importance to lung cancer patients and suggests that visual formats of learning, such as animations, can mitigate health literacy barriers and help improve patient understanding and outcomes. Exporting this format of learning to other cancers has the potential to benefit patients and improve health outcomes.
Exploring Key Capacities: Insights from Assessing the Resilience of the Public Health System Before and After the Kahramanmaraş Earthquakes
Authors: Tayfur Ismail , Kako Mayumi , Gündüz Abdülkadir , Rahman Md Moshiur , Şimşek Perihan , Ryan Benjamin , Garner Shelby , Bayramoğlu Burcu , Teramoto Chie , Takada Yosuke , Kubo Tatsuhiko , Bhatia Sanjaya 
Published: October 2024

AbstractThe goal of this mixed-methods study was to identify and compare the key capacity considerations regarding public health system resilience before and after the 2023 Türkiye-Syria earthquakes. Public health system resilience was assessed through online and face-to-face workshops using the United Nations Public Health System Resilience Scorecard. The pre-earthquake evaluation was conducted in Istanbul and Trabzon in 2021; the post-earthquake evaluation took place in Hatay and Kahramanmaraş in 2023, with a total of 41 participants each. The online workshops lasted approximately four days, while the face-to-face workshops lasted one day. The study found a significant decrease in the scores for most scorecard resilience indicators in the post-earthquake assessment. Qualitative analysis showed that this decline was largely due to infrastructure collapse. Additionally, defining the roles of health disciplines in disaster management and having data transmission procedures between public health system stakeholders in disasters were among the main capacity considerations in both the pre-and post-earthquake assessments. The post-earthquake evaluation revealed several capacity gaps that had not been addressed in pre-earthquake assessments in areas such as disaster preparedness of vulnerable populations and logistics. The findings highlight the critical importance of strengthening building stock and infrastructure to establish a disaster-resilient public health system.
The impact of reabsorption effect on composition analysis of organic semiconductors
Authors: Yang Bei , Liu Xiaoke , Wan Li , Ni Weixin , Yang Ni , Hou Jianhui , Gao Feng 
Published: October 2024

AbstractReabsorption is one of the most fundamental optical phenomena, but it has rarely been considered in spectroscopy-based composition analysis for organic semiconductors. Here, we take four state-of-the-art organic solar cell (OSC) materials as examples, and systematically investigate the influence of reabsorption on photoluminescence emission and excitation spectra by both experimental studies and optical simulations. We find that the overlap between absorption and emission spectra of these OSC materials is strong enough for them to be affected by the reabsorption effect, and the effect becomes more obvious between different species in the multi-components systems. Moreover, three features of the reabsorption effect and the reabsorption strength are identified, with which we have successfully analyzed the composition in a range of OSC materials in both solution and solid-state films. Our work not only provides an important understanding of the largely overlooked feature of reabsorption in the widely used spectroscopic techniques but also offers an effective toolbox for the composition analysis of organic semiconductors.