bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of glucocorticoids on anti-infective efficacy and prognosis of children with bronchiolitis caused by <i>Mycoplasma pneumoniae</i>
Authors: Jiang Fei , Mao Wenjie , Wan Yu , Yang Qianyuan , Fan Fei , Huang Zhiying 
Published: September 2024

Purpose: To investigate the effect of glucocorticoid administration on anti-infective efficacy and prognosis of children diagnosed with bronchiolitis caused by Mycoplasma pneumoniae (MP).
Methods: 100 children from January 2021 to June 2023 diagnosed with MP- induced bronchiolitis at the Department of Pediatrics, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China were randomized into study (n = 45) and control groups (n = 55). The study group received conventional medication (azithromycin at 10 mg/kg on the first day followed by 5 mg/kg/day for 5 days) in addition to glucocorticoids, while control group received the same conventional medication without glucocorticoids. The study group was treated with prednisone (2 mg/kg/day), once a day for 5 days. Inflammatory markers (C-reactive protein (CRP) and procalcitonin (PCT) levels) before and after treatment, duration of medication, disease course, clinical efficacy, and prognosis were compared.
Results: There was no significant difference in baseline characteristics between both groups (p > 0.05). The study group showed significantly reduced CRP and PCT levels, shorter medication and disease duration, and a higher efficacy compared to control group (p < 0.05).
Conclusions: Administration of glucocorticoids in addition to conventional medication in MP-induced bronchiolitis reduces levels of inflammatory markers, improves clinical symptoms, and enhances efficacy. Future studies using prospective, randomized controlled trials, larger sample sizes that cut across multicenter sites, standardized treatment protocols, and long-term follow-up will be required to more accurately confirm the safety and efficacy of glucocorticoids in the management of MP-induced bronchiolitis.
Effect of N-acetylcysteine aerosol inhalation on serum levels of inflammatory factors and immune function in children with upper airway cough syndrome
Authors: Zhong Mengmeng , Zheng Nan , Huang Hui 
Published: September 2024

Purpose: To investigate the influence of N-acetylcysteine (NAC) aerosol inhalation on serum inflammatory factors and immune function in children with upper airway cough syndrome (UACS).
Methods: 118 children with UACS who were on admission at Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, China between September 2021 and February 2023, were enrolled in the study. They were assigned to control and study cohorts, with 59 patients per group. Control group received routine treatment (3 mL of normal saline via nebulized inhalation 2 times/day), while the study group received 3 mL of NAC aerosol inhalation via nebulized inhalation 2 times/day. Both groups were treated for 2 weeks. Thereafter, the two groups were compared with respect to total treatment effectiveness, cough symptom and Lund-Kennedy ratings, levels of inflammatory factors (interleukin-13 (IL-13), interleukin-27 (IL-27), C-reactive protein (CPR)) and concentrations of immune function indices (CD3 + , CD4 + and CD8 + ) before and after treatment, and adverse reactions.
Results: Treatment effectiveness (efficacy) was significantly higher (p < 0.05) in study cohort than in control cohort (89.83 vs 71.19 %). The 2 cohorts had significant reductions in scores on cough symptoms and Lund-Kennedy, with smaller values in study cohort. In both groups, the levels of IL-13 and CPR were decreased, while IL-27 level was increased. Levels of IL-13 and CPR in study group were significantly lower than those in control group, while IL-27 level was significantly higher than that in control group (p < 0.05).
Conclusion: N-acetylcysteine aerosol inhalation enhances curative effect, relieves clinical symptoms, reduces inflammation, and improves immunity in UACS children, and shows good degree of safety. However, its long-term efficacy needs to be studied.
Impact of human papillomavirus (HPV) prophylactic vaccination on infertile male patients with HPV semen infection: A systematic review
Authors: Kanan Mohammed , Alotaibi Nawaf , Alshehri Rawan , Alhoqail Arwa , Abdulazim Kawther 
Published: September 2024

Purpose: To characterize the impact of prophylactic vaccination against human papillomavirus (HPV) on infertile male patients with HPV semen infection.
Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. First, an electronic search of PubMed, Scopus and Web of Science databases from 2018 to 2023 using specific keywords was conducted. Thereafter, three authors independently screened the articles and removed duplicates. Following the acquisition of the papers, a quality analysis was conducted using the Strengthening the Reporting of Observational Studies in Epidemiology Criteria.
Results: A total of 41 pregnancies were reported out of which 15.3 % were in control group and 38.9 % were in the vaccinated group (p < 0.05). The clearance of HPV DNA correlated significantly with a serum HPV antibody titer of ≥ 1:125 at initial examination. Compared with individuals who tested negative for HPV, those who became seropositive at 12 (p = 0.039), 18 (p = 0.034) and 24 months (p = 0.034) had fewer multiple infections and a lower incidence of HPV infection in semen.
Conclusion: Examination of the association between male fertility and HPV reveals a clear correlation between HPV infection and male infertility, specifically asthenospermia and oligoasthenospermia. Further studies are needed to fully understand the benefits of this approach in managing male infertility.
Modulation of inflammatory signaling pathways by natural products in osteoarthritis: Mechanisms, challenges, and future directions
Authors: Huynh Thu-Thao Thi , Quang Minh Trong , Vu Hai-Yen Thi 
Published: September 2024

Osteoarthritis (OA) is a degenerative joint disease that is characterized by dysregulated inflammatory signaling that disrupts cartilage homeostasis and presents a significant therapeutic challenge. Although current treatments primarily focus on symptom management, this review explores the growing interest in anti-inflammatory natural products as potential disease-modifying therapies. This review aims to: identify key inflammatory pathways as promising drug targets, summarize recent findings on natural products that modulate these pathways, and discuss challenges and future directions. A comprehensive literature search was conducted using databases such as PubMed and Web of Science, focusing on studies published in the last decade. Central to OA pathogenesis is persistent inflammation resulting from cytokine /chemokine-driven catabolic signaling, which is exacerbated by the overactivation of NFκB, MAPK, and PI3K/AKT pathways. Numerous plant-derived compounds exert inhibitory effects on these inflammatory cascades through mechanisms including NF-κB nuclear translocation suppression, MAPK phosphorylation blockade, and modulation of PI3K/AKT activity. However, clinical translation faces several complexities, such as bioavailability, precise targeting, and disease heterogeneity. Addressing these challenges using advanced technologies could enable the development of natural product-based OA therapeutics. Innovative research strategies are needed to fully leverage the therapeutic potential of these compounds in the management of OA.
Immunomodulatory potential and toxicological assessment of methanol extract and fractions of <i>Cryptolepis sanguinolenta</i> root
Authors: Eze Chinelo C. , Agbo Martina C. , Emencheta Stephen C. , Eze Osita C. , Evurani Somtochukwu A. 
Published: September 2024

Purpose: To evaluate the paramunity induction potentials of crude methanol extract (CME) and methanol fractions (MF) of Cryptolepis sanguinolenta (CS) root (Fam. Periplocaceae).
Method: A total of forty (40) albino rats were divided into two sets of four groups, with five animals per group. Groups 1 – 3 of both animal sets were orally administered 200, 300 and 500 mg/kg bw of CME and MF, respectively once daily for 14 days. Furthermore, Group 4 of both sets served as negative control. The effect of extracts on early-type hypersensitivity (ETH), delayed-type hypersensitivity (DTH), leukocyte count and haemagglutinin titer using sheep red blood cell (SRBC) as antigen were evaluated.
Results: Significant (p < 0.05) body weight gains were recorded in the animal groups treated with the ME while no changes were observed in the relative organ weight of all the animals in all the groups. Acute toxicity studies yielded no adverse effect. The CME and MF elicited significant (p < 0.05) increases and decreases in ETH and DTH, respectively, at all doses. They showed a significant (p < 0.05) dose-dependent, stimulatory effect on primary and secondary antibody titer across the treated groups. Packed cell volume and red blood cell count increased significantly (p < 0.05), while a dosedependent increase occurred in neutrophil counts in rats receiving CME, but the MF-treated rats had significantly decreased (p < 0.05) neutrophil counts at 300 mg/kg compared to control. Both CME and MF did not affect lymphocyte counts.
Conclusion: Cryptolepis sanguinolenta extract and MF produce significant stimulatory effects on humoral immunity (antibody) with non-significant impact on cellular and innate immunity. Future studies will require isolation and characterization of the bioactive compounds in the plant extracts.
Infestation and abundance of fruit flies of mango and orange from selected markets in Akwa Ibom State, Nigeria
Authors: Chikezie F.M. , Nnaji M.N. , Smidth S.F. , Akpan A.U. 
Published: September 2024

Mangoes and orange fruits need important consideration if fruit production is to be successful and sustainable. Insect pests and diseases threaten the profitability of mango and orange farming. In particular, fruit flies have become an increasingly prevalent insect in Nigeria, owing to the damage incidence and economic losses, especially to the mango and orange value chains. This study was conducted to determine the species composition, abundance and prevalence of fruit flies on mango and orange fruits from Akwa Ibom State. Two (2) varieties of mango fruits comprising German and cherries types were gotten from 2 markets (Etinan urban and Itam markets) while oranges were obtained from 3 markets (Akpan Andem, Itam and Mbiopkoro markets). Fruits were kept in the laboratory in cups and covered in such a way as to keep them away from any other pests and prevent emerging fruit flies from escaping. The samples were studied at ambient conditions and were incubated for up to 4 weeks until all the fruit flies emerged as adults. Three species of fruit fly were identified from the different types of mango namely: Drosophila melanogaster, Bactrocera dorsalis and Bactrocera papayae. Mango fruits from Etinan urban had the highest abundance of fruit flies infestation than those from Itam market (81.7% and 18.3%) respectively. Among the fruit flies encountered during the study, Drosophilia melanogaster had the highest prevalence (95.4%) and the least was Bactrocera papayae (1.42%). Two species of fruit flies (Drosophila melanogaster and Bactrocera dorsalis) were identified on oranges. Drosophila melanogaster was higher in abundance (79.38%) than Bactrocera dorsalis (20.62%). Oranges from Mbiokporo were the most affected. Species diversity and evenness were slightly different amongst the 3 markets. The current study has shown Mango and orange fruit flies infestation to be a serious threat to fruit production in Akwa Ibom State. Since the population of these pests are detrimental to the economic values of mango and orange fruits, control measures should be put in place.
On Newton and Lagrange Interpolation Method for first order ordinary differential equations
Authors: Udoh P.J. , Nsien E.F. , Abasiekwere U.A. 
Published: September 2024

In the recent past, there has been a tremendous growth of the solution of differential equations using algorithmic methods. This work deploys Newton’s interpolation polynomial method (NIPM) and Lagrange interpolation polynomial method (LIPM) to create cubic polynomials for solving initial value problems of the first order. The results obtained show greater accuracy for the investigated method when compared with some known methods in literature. Illustrative examples are presented to demonstrate the validity and applicability of the technique.
Politogenesis and Faith: on Confessional History of the Lithuanian-Russian State and Rus’
Authors: Дворниченко А.Ю. 
Published: September 2024

Статья продолжает дискуссию касательно конфессиональной истории Литовско-Русского государства и Руси. Главная идея заключается в том, что столь медленное и постепенное внедрение христианства в сообщества Восточной (и Центральной) Европы, в частности Литвы, настоятельно требует понимания корреляции между христианизацией и становлением государства в этом регионе. Замедленность процесса политогенеза обусловила и довольно затяжную христианизацию, хотя, конечно, христианские конфессии оказались в различных условиях в разных регионах Восточной Европы.
The article presents a further discussion on the confessional history of the LithuanianRussian State and Rus’. The main idea is that a slow and gradual infiltration of Christianity into the societies of Eastern (and Central) Europe, including Lithuania, can be explained by the correlation between Christianization and the formation process of the state in this region. The process of politogenesis was slow, which also resulted in a rather prolonged Christianization, but of course, Christian denominations were to develop under different conditions in different regions of Eastern Europe.
Pengaruh Penerapan Sistem E-Filing, Pengetahuan, Perpajakan dan Sanksi Perpajakan Terhadap Kepatuhan Wajib Pajak Dengan Sosialisasi Perpajakan Sebagai Variabel Moderasi
Authors: Akbar M Rafaiz , Azhar Mhd Karya Satya , Sani Ahmad 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh Penerapan Sistem e-filing pengetahuan perpajakan, dan sanksi perpajakan terhadap kepatuhan wajib pajak dengan sosialisasi perpajakan sebagai variabel moderating pada KPP Pratama Medan Petisah. Sampel dalam penelitian ini adalah 100 wajib pajak orang pribadi yangterdaftar di KPP Pratama Medan Petisah. Teknik analisis data dalam penelitian ini mengunakan uji asumsi klasik dan Moderated Regression Analysis (MRA).
Berdasarkan hasil penelitian menunjukkan bahwa Penerapan Sistem eFiling tidak berpengaruh signifikan terhadap kepatuhan wajib pajak, Pengetahuan Perpajakan berpengaruh signifikan terhadap kepatuhan wajib pajak, dan sanksi perpajakan tidak berpengaruh signifikan terhadap sosialisasi perpajakan. Sosialisasi Perpajakan tidak dapat memoderasi hubungan antara Penerapan Sistem e-Filing terhadap kepatuhan wajib pajak. Sosialisasi Perpajakan dapat memoderasi untuk hubungan antara Pengetahuan Perpajakan terhadap kepatuhan wajib pajak dan Sosialisasi Perpajakan tidak dapat memoderasi untuk hubungan antara sanksi pajak terhadap kepatuhan wajib pajak.
Pengaruh Kapabilitas Relasi Terhadap Penciptaan Nilai dan Kinerja Pemasaran Dengan Kapabilitas Pemasaran Dinamis Sebagai Variabel Moderasi
Authors: Hutagalung Syopwan Alrasid , Aditi Bunga , Fahlevi Alvin 
Published: September 2024

The results in this study indicate that the variables of relational capabilities and have a significant influence on value creation and market performance,. For the dynamic market capabilities variable which acts as a moderating variable, in this study the variable dynamic market capabilities is not able to moderate positively between the variables of relational capabilities with value creation and market performance This study aims to determine relation capabilities, on interest in value creation and market performance with dynamic market capabilities as a moderating variable (research study on owner brand clothing in Medan city). The research design used moderated multiple linear regression analysis. as an analytical tool to find out how the influence between the independent and dependent variables is moderated by the moderating variable. This study uses an associative research type with a quantitative approach. The population and sample in this study, namely for the population based on owner brand clothing in Medan city with a sample of 101owner brand clothing in medan city.
Commitment Organization Ditinjau Dari Work Life Balance, Perceived Organizational Support , Dan Development Career Melalui Job Satisfaction Sebagai Variabel Intervening Pada PT Global Indonesia Asia Sejahtera Medan
Authors: Handayani Sri Putri , Azhmy Muhammad Fauzan , Aditi Bunga 
Published: September 2024

Penelitian ini bertujuan untuk menguji “Commitment Organization ditinjau dari Work Life Balance, Perceived Organizational Support dan Development Career Terhadap Melalui Job Satisfaction Sebagai Variabel Intervening Pada PT Global Indonesia Asia Sejahtera”. Metode pengumpulan sampel yaitu sampel jenuh dengan jumlah sampel yaitu 104 orang. Metode analisis data yang digunakan adalah analisis jalur dengan menggunakan bantuan komputer dengan software program SPSS versi 21. Adapun teknik pengambilan data dengan menggunakan skala likert.
Hasil penelitian yang diperoleh yaitu Work life balance (X1) secara langsung berpengaruh terhadap job satisfaction (Y1), Perceived organizational support (X2) secara langsung berpengaruh terhadap job satisfaction (Y1), Career development (X3) secara langsung berpengaruh terhadap job satisfaction (Y1), Work life balance (X1) secara langsung tidak berpengaruh terhadap commitment organization (Y2), Perceived organizational support (X2) secara langsung berpengaruh terhadap commitment organization (Y2), Career development (X3) secara langsung berpengaruh terhadap commitment organization (Y2), Job satisfaction (Y1) secara langsung berpengaruh terhadap commitment organization (Y2), Work life balance (X1) secara tidak langsung melalui job satisfaction (Y1) mempunyai pengaruh signifikan terhadap commitment organization (Y2), Perceived organizational support (X2) secara tidak langsung melalui job satisfaction (Y1) berpengaruh secara positif dan signifikan terhadap commitment organization (Y2). Career development (X3) secara tidak langsung melalui job satisfaction (Y1) berpengaruh secara positif dan signifikan terhadap commitment organization (Y2)
.
Kata kunci: Work Life Balance, Perceived Organizational Support and Career Development, Job Satisfaction, Commitment Organization
Pengaruh Brand Image dan Product Quality Terhadap Brand Loyalty Dimediasi Brand Trust Pada Pengguna Depok Bubble Drink Kota Medan
Authors: Ferdinansyah Hendy , Azhmy Muhammad Fauzan , Nasution Aulia Arief 
Published: September 2024

Penelitian ini dilakukan pada DBD Powder Medan yang merupakan perusahaan yang bergerak di bidang penjualan bubuk minuman cepat saji. Tujuan penelitian ini adalah untuk mengetahui pengaruh Brand Image dan Product Quality terhadap Brand Loyalty di mediasi Brand Trust pada Pengguna Depok Bubble Drink Kota Medan. Populasi adalah konsumen yang datang dan membeli produk perusahaan dengan rata-rata perbulan sebanyak 3.250 konsumen, pengambilan sampel menggunakan rumus Slovin sehingga jumlah sampel sebanyak 100 responden. Sumber data menggunakan data primer dan teknik pengumpulan data adalah studi pustaka, observasi dan kuesioner. Teknik analisis data terdiri dari uji kualitas data, uji asumsi klasik, analisis jalur dan uji hipotesis
Berdasarkan hasil penelitian menunjukkan bahwa secara parsial menunjukkan bahwa brand image berpengaruh signifikan terhadap brand loyalty, product quality berpengaruh signifikan terhadap brand trust. Sementara itu, brand image tidak berpengaruh signifikan pada brand trust, dan product quality tidak berpengaruh signifikan terhadap brand loyalty. Secara simultan menunjukkan bahwa brand image, product quality dan brand trust secara bersama-sama berpengaruh positif dan signifikan terhadap brand loyalty di DBD Powder Medan. Korelasi antara brand image, product quality dan brand trust dapat dikatakan kuat terhadap brand loyalty di DBD Powder Medan. Sedangkan besarnya persentase kemampuan brand image, product quality dan brand trust untuk dapat menjelaskan brand loyalty sebesar 36,7% dan sisanya 63,3% dapat dijelaskan oleh variabel lainnya yang tidak diteliti seperti promosi, harga, pelayanan dan sebagainya.

Kata kunci: Brand Iamge, Product Quality, Brand Trust, Brand Loyalty
Pengaruh Network Behavior Terhadap Venture Performance Dengan Social Capital dan Tacit Knowledge Sebagai Variabel Mediasi
Authors: Dandi  , Muhar Ani Muwarni , Nahrisah Ezzah 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh network behavior terhadap venture performance dengan social capital dan tacit knowledge sebagai variabel mediasi pada usaha kecil di kecamatan percut sei tuan. Desain penelitian adalah analisis regresi sebagai alat analisis dan metode kausal step digunakan untuk mengetahui bagaimana pengaruh antara variabel independen dan dependen dengan dimediasi oleh variabel mediating. Dalam penelitian ini menggunakan jenis penelitian asosiatif dengan paradigma kuantitatif. Populasi dan sampel yang digunakan dalam penelitian ini, yaitu seluruh usaha kecil yang ada pada kecamatan percut sei tuan sejumlah 295 usaha dengan sampel 170 usaha.
Hasil pada penelitian ini menunjukkan bahwa variabel network behavior berpengaruh positif dan signifikan terhadap variable venture performance. Untuk variabel social capital berpengaruh secara signifikan terhadap variable venture performance, begitu juga dengan variabel tacit knowledge yang berpengaruh secara signifikan terhadap variable venture performance.
Pengaruh Kreativitas, Sikap Kewirausahaan dan Self Efficacy Terhadap Keberhasilan Usaha Dengan Pengetahuan Kewirausahaan Sebagai Variabel Moderasi (Studi Pada: Universitas Harapan Medan)
Authors: Wilaini Salsabila Putri 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui kreativitas, sikap kewirausahaan, dan self efficacy terhadap keberhasilan usaha dengan pengetahuan kewirausahan sebagai variabel moderasi pada Universitas Harapan Medan. Desain penelitian analisis regresi berganda digunakan sebagai alat analisis untuk menentukan arah variabel yang diteliti serta menjustifikasi seberapa signifikansi pengaruh variabel independen dengan dependen baik secara langsung maupun tidak langsung melalui variabel moderasi. Dalam penelitian ini menggunakan metode penelitian asosiatif dengan pendekatan kuantitatif. Dalam penelitian ini seluruh populasi yang menjadi sampel, yaitu 100 mahasiswa stambuk 2018, 2019 dan 2020 Universitas Harapan Medan yang berwirausaha.
Hasil dari penelitian ini menunjukkan bahwa variabel kreativitas berpengaruh positif dan signifikan terhadap keberhasilan usaha. Sikap kewirausahaan berpengaruh positif dan signifikan terhadap keberhasilan usaha. Self efficacy berpengaruh positif dan signifikan terhadap keberhasilan usaha. Pengetahuan kewirausahaan memoderasi pengaruh kreativitas terhadap keberhasilan usaha. Pengetahuan kewirausahaan memoderasi sikap kewirausahaan terhadap keberhasilan usaha. Pengetahuan kewirausahaan memoderasi pengaruh self efficacy terhadap keberhasilan usaha.