bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feeling better now? Being defended diminishes daily mood problems and self‐blame in victims of bullying
Authors: Laninga‐Wijnen Lydia , Pouwels J. Loes , Giletta Matteo , Salmivalli Christina 
Published: September 2024

AbstractBackgroundSchool bullying is a group phenomenon in which being defended by peer bystanders may buffer against the development of psychological problems in victims.AimsThis registered report examines whether being defended diminished victims' daily mood problems and self‐blame, both from a within‐ and between‐person perspective.Materials and MethodsDaily diary data were collected from n = 1669 Finnish 7th–9th grade students (M age = 14.45; 55.5% girl) across 3 weeks. In n = 1329 out of 12,366 assessments (10.7%), students indicated that schoolmates victimized them on the day of bullying.ResultsMulti‐level regression analyses indicated that students reported lower depressed mood, greater positive mood and lower self‐blame on days that they were victimized and defended as compared to days when they were victimized but non‐defended. Effect sizes were medium for depressed mood and small for positive mood and self‐blame. Repeated victims (n = 144) were less likely to blame themselves for victimization on days they were defended, which, in turn, diminished feelings of humiliation (mediation).DiscussionOur findings indicate that being defended benefits victims of bullying by mitigating mood problems, both directly and indirectly via diminished self‐blame.ConclusionAnti‐bullying programmes that encourage peer defending have the potential to improve victims' psychological adjustment, even on a daily basis.
Loss of USP10 promotes hepatocellular carcinoma proliferation by regulating the serine synthesis pathway through inhibition of LKB1 activity
Authors: Ma Chi , Lin Zhikun , Yao Jiaqi , Qin Wangshu , Wang Xiaolin , Li Qi , Ye Yaorui , Liu Xinyu , Chen Fating , Hu Jinlong , Xu Guowang , Tan Guang 
Published: September 2024

AbstractMetabolic dysregulation is emerging as a critical factor in tumorigenesis, and reprogramming of serine metabolism has been identified as an essential factor in the progression of hepatocellular carcinoma (HCC). Studies have shown that LKB1 deficiency can activate mTOR to upregulate the serine synthesis pathway (SSP) and promote tumor progression. Our team discovered that ubiquitin‐specific protease 10 (USP10) can inhibit HCC proliferation through mTOR, but its relationship with SSP needs further investigation. The metabolite assays revealed a significant increase in serine content in HCC tissues. Through the LKB1/mTOR/activating transcription factor 4 (ATF4) axis, loss of USP10 may increase serine biosynthesis and promote the proliferation of HCC in vitro and in vivo. Furthermore, it was found that USP10 could activate LKB1 through deubiquitination. Analyzing clinical HCC tissues revealed a positive correlation between USP10 and LKB1. Additionally, those with high expression of USP10 in HCC tissues showed a better degree of tumor differentiation and longer overall survival time. Moreover, we found increased expression of both serine and its synthase in liver tumor tissues of USP10 liver‐specific KO mice. Loss of USP10 inhibits the activity of LKB1, contributing to the stimulation of the mTOR/ATF4 axis and SSP and then promoting the proliferation of HCC. This work presents a novel approach for serine‐targeted treatment in HCC.
Specific cancer types and prognosis in patients with variations in the KEAP1‐NRF2 system: A retrospective cohort study
Authors: Iwasaki Tomoyuki , Shirota Hidekazu , Sasaki Keiju , Ouchi Kota , Nakayama Yuki , Oshikiri Hiroyuki , Otsuki Akihito , Suzuki Takafumi , Yamamoto Masayuki , Ishioka Chikashi 
Published: September 2024

AbstractThe KEAP1–NRF2 system induces the expression of antioxidant genes in response to various types of oxidative stress. Some cancer cells activate this system, which increases their malignancy through genetic mutations. We performed a retrospective cohort study using the C‐CAT database, which contains the gene‐panel sequence data from 60,056 cases of diagnosed solid tumors. We analyzed somatic mutations in NRF2 and KEAP1 genes and their associations with clinical outcomes. Variants in the NRF2 gene were clustered in exon 2, which encodes the DLG and ETGE motifs essential for KEAP1 interaction. The NRF2 variants were frequently observed in esophageal and lung squamous cell carcinoma with frequencies of 35.9% and 19.6%, respectively. Among these mutations, the NRF2 variants in the ETGE motif were indicators of a worse prognosis. KEAP1 variants were found in 2.5% of all cases. The variants were frequent in lung cancer and showed a worse prognosis in lung and other types of adenocarcinomas. We then conducted gene expression analysis using TCGA data. While cancers with DLG and ETGE variants were similar in terms of gene expression profiles, there were significant differences between cancers with KEAP1 and NRF2 variants. Our results indicate that genetic alteration of the KEAP1–NRF2 pathway is a major factor in patient prognosis for each cancer type and its genetic variant. Variants in NRF2 and KEAP1 genes can characterize the biological basis of each cancer type and are involved in carcinogenesis, resistance to therapy, and other biological differences.
Efficacy of Nortriptyline and Migraine Lifestyle Modifications in Vestibular Migraine Management
Authors: Frank Madelyn , Tawk Karen , Lee Ella J. , Kim Joshua K. , Al‐Seraji Abdula , Abouzari Mehdi , Djalilian Hamid R. 
Published: September 2024

ABSTRACTObjectiveTo evaluate the effectiveness of nortriptyline regimen and migraine dietary/lifestyle modifications on dizziness and stress levels in patients diagnosed with vestibular migraine (VM).MethodsA total of 35 patients diagnosed with definite VM based on the International Classification of Headache Disorders were included in this intervention study. Patients self‐selected to receive either nortriptyline regimen alone (10–40 mg daily with biweekly escalation) (group A, n = 17) or migraine dietary/lifestyle modifications alone (group B, n = 18). Main outcome measures were dizziness severity and stress level measured by the visual analog scale (VAS).ResultsAt 4‐week post‐treatment, dizziness decreased from 6.0 ± 2.5 to 4.2 ± 3.4 (p = 0.069) in group A and from 8.7 ± 1.5 to 3.6 ± 3.0 (p < 0.001) in group B. VAS for stress changed from 5.5 ± 1.3 to 5.4 ± 2.9 (p = 0.93) and from 6.9 ± 3.2 to 5.0 ± 2.7 (p = 0.025) in groups A and B, respectively. The δ values of the VAS score for dizziness were 1.8 ± 3.7 and 5.1 ± 3.1 and the δ values of the VAS score for stress were 0.06 ± 2.9 and 1.9 ± 3.3 in groups A and B, respectively. Quality of life (QOL) improved in 88% patients in group A and 94% patients in group B.ConclusionsNortriptyline, at a maximum dose of 40 mg, effectively alleviates patient symptoms, while a migraine diet and lifestyle modifications notably reduce vertiginous symptoms and stress levels in VM patients in 4 weeks. Both interventions are equally effective in ameliorating the QOL of patients. The ideal treatment for patients would likely need to include both medication and diet/lifestyle changes.
Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen
Authors: Marmgren V. , Mowitz M. , Zimerson E. , Hindsén M. , Bruze M. 
Published: September 2024

AbstractObjectivePhotoallergic reactions due to topical ketoprofen are common. As some simultaneous contact allergies have been described in the literature, we aimed to get an overview of the pattern of reactivity towards common allergens in the baseline series in ketoprofen‐photoallergic individuals.MethodsUsing our database, we found 94 patients with photocontact allergy to ketoprofen diagnosed during 1999–2018. Approximately 12 800 patients patch tested with the baseline series during the same time frame served as controls. Data on patch testing with the baseline series of 518 individuals belonging to the general population were obtained from an earlier study, and a comparison of allergy rates was made with the ketoprofen group.ResultsContact allergy to fragrance mix I and Myroxylon pereirae was overrepresented among patients with photocontact allergy to ketoprofen (42.3% vs. 6.6% and 47.9% vs. 6.6%, p < 0.001, respectively). Significant overrepresentation was also shown for 4‐tert‐butylphenolformaldehyde resin (PTBP‐F‐R), phenol formaldehyde resin (PFR‐2), black rubber mix, budesonide (all p < 0.001), and fragrance mix II (p = 0.02). The pattern was similar, but with lower significance levels for fragrance mix II and budesonide, regardless of whether or not the individuals had been photopatch tested because of a suspected photoallergic contact dermatitis from ketoprofen.ConclusionContact allergy to fragrance mix I, Myroxylon pereirae, black rubber mix, PFR‐2, PTBP‐FR, and to a somewhat lower extent, to fragrance mix II and budesonide, is common in individuals photoallergic to ketoprofen. It remains to be seen whether sensitisation to ketoprofen leads to simultaneous sensitisation to a number of other, chemically non‐related, substances.
Association of dementia with impaired kidney function and plasma biomarkers: A population‐based study
Authors: Wang Nan , Ma Yixun , Liang Xiaoyan , Fa Wenxin , Tian Xunyao , Liu Cuicui , Zhu Min , Tian Na , Liu Keke , Tang Shi , Song Lin , Cong Lin , Dai Lu , Xu Hong , Wang Yongxiang , Hou Tingting , Du Yifeng , Qiu Chengxuan 
Published: September 2024

AbstractBackground and PurposeEmerging evidence has linked impaired kidney function with dementia in older adults, but the neuropathological pathways underlying their association remain poorly understood. We sought to examine the relationships of kidney function with dementia and plasma biomarkers in a Chinese rural population.MethodsThis population‐based study used data from the baseline examination of the Multimodal Interventions to Delay Dementia and Disability in rural China (MIND‐China) cohort (March–September 2018; n = 5715). Kidney function was assessed using estimated glomerular filtration rate (eGFR) based on serum creatinine level. Dementia, Alzheimer's disease (AD) and vascular dementia (VaD) were diagnosed according to the international criteria. Plasma biomarkers were measured using the SIMOA platform in a subsample (n = 1446). Data were analyzed using logistic, general linear, and mediation models.ResultsOf the 5715 participants, 306 were diagnosed with dementia, including 195 with AD and 100 with VaD. Impaired kidney function (eGFR <60 vs. ≥90 mL/min/1.73 m2) was associated with multivariable‐adjusted odds ratios of 2.24 (95% confidence interval [CI] 1.44–3.46) for all‐cause dementia, 1.85 (1.07–3.18) for AD, and 2.49 (1.16–5.22) for VaD. In the biomarker subsample, impaired kidney function was significantly associated with higher plasma amyloid‐β (Aβ)40 (β‐coefficient = 54.36, 95% CI 43.34–65.39), Aβ42 (β‐coefficient = 3.14, 95% CI 2.42–3.86), neurofilament light chain (β‐coefficient = 10.62, 95% CI 5.62–15.62), and total tau (β‐coefficient = 0.68, 95% CI 0.44–0.91), and a lower Aβ42/Aβ40 ratio (β‐coefficient = −4.11, 95% CI −8.08 to −0.14). The mediation analysis showed that plasma total tau significantly mediated 21.76% of the association between impaired kidney function and AD (p < 0.05).ConclusionImpaired kidney function is associated with dementia and plasma biomarkers among rural‐dwelling older Chinese adults, and the association with AD is partly mediated by plasma biomarkers for neurodegeneration.
Effects of microstructures on the fracture properties of silicon nitride ceramics at elevated temperatures
Authors: Cheng Tianbao , Lv Jingwen , Wu Derong , Wu Danyan 
Published: September 2024

AbstractCeramic components often fail by a brittle fracture mode during the service process. Various factors can affect the fracture properties of ceramics. Experimental methods are usually used to investigate fracture behaviors. However, they give a composite result and the contribution to fracture from each factor is not clear. In the present work, a micromechanical model is developed to quantitatively characterize the fracture properties of ceramics at elevated temperatures. The control method for the microstructures of ceramics is proposed based on the Voronoi diagram. The temperature‐dependent surface energy model of ceramics is revised by considering the effects of thermal decomposition and phase transformation. The interface energies at different temperatures are obtained by the inversion method. The criterion for crack propagation of ceramics at elevated temperatures is developed based on the G‐criterion. The effects of temperature, grain size, grain size distribution, and grain boundary phase thickness on the fracture behaviors of silicon nitride are studied numerically.
Navigating high‐cost medicines: summary of the Guiding Principles for the governance of high‐cost medicines in Australian hospitals
Authors: Hill Catherine L. , Pulver Lisa K. , Liew David F. L. ,   the Council of Australian Therapeutic Advisory Groups
Published: September 2024

AbstractHigh‐cost medicines (HCMs) can be clinically impactful for individual patients but are also subject to variable funding mechanisms. Public hospitals and health services are often asked to fund HCMs, but inconsistent processes frequently create large variations in care. CATAG (Council of Australian Therapeutic Advisory Groups) is the Australian peak national advisory body for the quality use of medicines in hospitals and health services, with all states and territories collaborating to support Drug and Therapeutics Committees (DTCs). CATAG has developed national Guiding Principles to assist DTCs to effectively govern HCMs. An established process for the development of CATAG Guiding Principles was undertaken to develop these Guiding Principles. This includes the formation of an Expert Advisory Group (EAG) comprising individuals with recognised expertise, development of draft principles and stakeholder consultation from within the CATAG membership and externally. All feedback was discussed, and changes were agreed upon. The final version was approved by the EAG and CATAG members. This document represents a summary of the seven Guiding Principles developed, covering the areas of governance, application and assessment, communication, training and resourcing. Although many outstanding priorities still exist, including the development of national coordination regarding HCM assessment, these Guiding Principles offer a basis to navigate this complex area.
Trends in Hospitalisations for Vaccine Preventable Respiratory Infections Following Emergency Department Presentations in New South Wales, Australia, 2012–2022
Authors: Hossain Fariha Binte , Muscatello David , Jayasinghe Sanjay , Liu Bette 
Published: September 2024

ABSTRACTBackgroundVaccine‐preventable respiratory infections impact on healthcare systems globally. Despite availability of vaccines, fluctuations in vaccination rates, pathogen virulence and community transmission dynamics mean that these respiratory infections continue to pose substantial public health risks. To understand trends in vaccine‐preventable respiratory infections, we analysed linked data from emergency department (ED), hospitalisations and deaths in New South Wales, Australia, from 2012 to 2022.MethodsED presentations with respiratory infection like illness were linked to hospitalisation and death records. Age‐standardised rates of ED presentations, proportions subsequently hospitalised for acute respiratory infection (ARI) and specific vaccine‐preventable disease diagnoses and 28‐day mortality rates were estimated by year and age.ResultsFrom 2012 to 2022, there were 3,127,090 ARI‐like ED presentations. Age‐standardised rates increased until 2020, declined in 2021 and rebounded in 2022. Across all years, of these ARI‐like ED presentations, 16.6% were hospitalised for acute respiratory infections, including pneumonia (7.9%), influenza (1.1%), RSV disease (1.3%), COVID‐19 (0.8%) and pneumococcal disease (0.3%). Proportions hospitalised were highest in those aged 65+ years, except for RSV, which was highest in children aged 0–4 years. The highest 28‐day mortality post‐ARI‐like ED presentation was observed with COVID‐19 in adults aged 65+ years at 13.1%.ConclusionsThis study highlights the continuing burden of vaccine‐preventable respiratory infections on an Australian healthcare system. These data can be used to monitor the effectiveness of vaccination programmes and other public health interventions. Future efforts should focus on enhancing surveillance and data linkage to improve precision and guide targeted public health strategies.
Effects of preconceptional vitamin D levels on in vitro fertilization outcomes in infertile patients with polycystic ovary syndrome: A retrospective cohort study
Authors: Tunçcan Emre , Mohri Parsa , Dikeç Mirkan , Karaawi Fatimah , Kazaz Elif , Kocatepe Cavit , Dokuzlu Gizem , Tıraş Bülent , Çakıroğlu Ahmet Yiğit , Korun Zeynep Ece Utkan 
Published: September 2024

AbstractBackgroundVitamin D plays various roles in different stages of reproduction, and abnormalities in its levels are associated with diseases such as polycystic ovary syndrome (PCOS). This study aimed to determine the relationship between initial vitamin D levels and in vitro fertilization (IVF) outcomes in PCOS patients.MethodsThis retrospective cohort study included 1174 PCOS patients who consulted the Acıbadem Maslak Hospital IVF Clinic between January 2015 and March 2021. We investigated the effect of preconceptional vitamin D levels on IVF outcomes using data analysis with SigmaPlot 14.5.ResultsWe found a significant positive correlation between preconceptional vitamin D levels and positive clinical pregnancy rates (p < 0.001) as well as increased endometrial thickness (EMT) on human chorionic gonadotropin (hCG) day (p < 0.001, r = 0.262). The optimal vitamin D cut‐off value for predicting positive hCG test results was identified as 13.24 ng/mL, as determined by receiver operating characteristic curve analysis (sensitivity = 0.839, specificity = 0.677). No association was observed with other IVF outcome parameters, miscarriage rates, or clinical pregnancy rates based on EMT.ConclusionsThe study suggests that PCOS patients with vitamin D levels above 13.24 ng/mL are more likely to achieve positive hCG results after IVF. These findings highlight the potential importance of vitamin D supplementation in improving pregnancy outcomes for PCOS patients. Additionally, increased EMT on hCG day may explain the higher clinical pregnancy rates associated with elevated vitamin D levels.
A moving target: trade‐offs between maximizing carbon and minimizing hydraulic stress for plants in a changing climate
Authors: Quetin Gregory R. , Anderegg Leander D. L. , Boving Indra , Trugman Anna T. 
Published: September 2024

Summary

Observational evidence indicates that tree leaf area may acclimate in response to changes in water availability to alleviate hydraulic stress. However, the underlying mechanisms driving leaf area changes and consequences of different leaf area allocation strategies remain unknown.

Here, we use a trait‐based hydraulically enabled tree model with two endmember leaf area allocation strategies, aimed at either maximizing carbon gain or moderating hydraulic stress. We examined the impacts of these strategies on future plant stress and productivity.

Allocating leaf area to maximize carbon gain increased productivity with high CO2, but systematically increased hydraulic stress. Following an allocation strategy to avoid increased future hydraulic stress missed out on 26% of the potential future net primary productivity in some geographies. Both endmember leaf area allocation strategies resulted in leaf area decreases under future climate scenarios, contrary to Earth system model (ESM) predictions.

Leaf area acclimation to avoid increased hydraulic stress (and potentially the risk of accelerated mortality) was possible, but led to reduced carbon gain. Accounting for plant hydraulic effects on canopy acclimation in ESMs could limit or reverse current projections of future increases in leaf area, with consequences for the carbon and water cycles, and surface energy budgets.
Bridging the gap: unravelling plant centromeres in the telomere‐to‐telomere era
Authors: Naish Matthew 
Published: September 2024

SummaryCentromeres are specific regions of the chromosomes that play a pivotal role in the segregation of chromosomes, by facilitating the loading of the kinetochore, which forms the link between the chromosomes to the spindle fibres during cell division. In plants and animals, these regions often form megabase‐scale loci of tandemly repeated DNA sequences, which have presented a challenge to genomic studies even in model species. The functional designation of centromeres is determined epigenetically by the incorporation of a centromere‐specific variant of histone H3. Recent developments in long‐read sequencing technology have allowed the assembly of these regions for the first time and have prompted a reassessment of fidelity of centromere function and the evolutionary dynamics of these regions.
The Arabidopsis splicing factor PORCUPINE/SmE1 orchestrates temperature‐dependent root development via auxin homeostasis maintenance
Authors: El Arbi Nabila , Nardeli Sarah Muniz , Šimura Jan , Ljung Karin , Schmid Markus 
Published: September 2024

Summary

Appropriate abiotic stress response is pivotal for plant survival and makes use of multiple signaling molecules and phytohormones to achieve specific and fast molecular adjustments. A multitude of studies has highlighted the role of alternative splicing in response to abiotic stress, including temperature, emphasizing the role of transcriptional regulation for stress response. Here we investigated the role of the core‐splicing factor PORCUPINE (PCP) on temperature‐dependent root development.

We used marker lines and transcriptomic analyses to study the expression profiles of meristematic regulators and mitotic markers, and chemical treatments, as well as root hormone profiling to assess the effect of auxin signaling.

The loss of PCP significantly alters RAM architecture in a temperature‐dependent manner. Our results indicate that PCP modulates the expression of central meristematic regulators and is required to maintain appropriate levels of auxin in the RAM.

We conclude that alternative pre‐mRNA splicing is sensitive to moderate temperature fluctuations and contributes to root meristem maintenance, possibly through the regulation of phytohormone homeostasis and meristematic activity.