bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular survey of haemoplasmas in shelter dogs and associations with Rhipicephalus sanguineus sensu lato
Authors: AKTAS M. , OZUBEK S. 
Published: July 2017

AbstractThis study aimed to assess the occurrence of canine haemoplasma infection in domestic dogs and its possible trans‐stadial transmission by Rhipicephalus sanguineus sensu lato (Ixodida: Ixodidae) in shelter dogs in Diyarbakır Province in southeast Turkey. Blood samples (n = 282) collected from domestic dogs were analysed by polymerase chain reaction (PCR) for the presence of canine haemoplasma. Fully engorged nymphs (n = 204) were removed from dogs that were positive for canine haemoplasma by PCR and maintained in an incubator at 28 °C for moulting. Unfed ticks (n = 2185) comprising 2100 nymphs and 85 adults collected from the grounds of the same shelter were also screened. Of 282 dogs, 108 [38.3%, 95% confidence interval (CI) 32.6–44.2] were PCR‐positive for canine haemoplasmas. Mycoplasma haemocanis (Mhc) infection (26.2%, 95% CI 21.2–31.8) was observed in a significantly higher number of dogs than was Candidatus Mycoplasma haematoparvum (CMhp) infection (6.7%, 95% CI 4.1–10.3). Co‐infections were seen in 15 (5.3%, 95% CI 3.0–8.6) dogs. None of the tick specimens examined were found to be positive for haemoplasma. Partial sequences of the 16S ribosomal RNA (rRNA) gene shared 99–100% identity with the corresponding published sequences for Mhc and CMhp. The present results revealed no trans‐stadial transmission of canine haemoplasma species by R. sanguineus s.l. in field conditions.
Long term follow up of kidney donors with asymptomatic renal stones
Authors: Serur David , Charlton Marian , Juluru Krishna , Salama Gayle , Locastro Eve , Bretzlaff Gretchen , Hartono Choli 
Published: July 2017

AbstractPatients with asymptomatic kidney stones have a high rate of progression to becoming symptomatic kidney stones when followed for several years. Small kidney stones are often found incidentally on imaging when evaluating patients for kidney donation, and there is a concern that after nephrectomy, the donor may become symptomatic and incur damage to the remaining kidney. We reviewed kidney donors at our institution with asymptomatic stones and surveyed them several years after donation to see if the stones became clinically active.
Acquired Gitelman syndrome in a primary Sjögren syndrome patient with a SLC12A3 heterozygous mutation: A case report and literature review
Authors: Gu Xiangchen , Su Zheling , Chen Min , Xu Yanqiu , Wang Yi 
Published: July 2017

AbstractAcquired Gitelman's syndrome (GS) associated with Sjögren syndrome (SS) is rare. A 50‐year‐old woman was admitted to our department because of nausea, acratia and sicca complex. Laboratory tests after admission showed renal failure, hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria, all of which met the diagnostic criteria for GS. Diagnostic evaluation identified primary SS as the cause of the acquired GS. Light microscopy of the renal tissue from the patient showed severe membranoproliferative glomerunephritis and tubulointerstitial nephritis. Immunohistochemical staining of the renal tissue showed the absence of sodium‐chloride co‐transporter (NCCT) in distal convoluted tubules. Genetic analysis of chromosomal DNA extracted from the patient's peripheral blood showed SLC12A3 gene heterozygous mutation. The reported case was comprehensively analyzed on the basis of the clinical features, and laboratory, pathological and genetic test findings. The patient has achieved a complete remission after meticulous care and appropriate treatment.
Effect of near‐infrared rays on female menstrual pain in Korea
Authors: Lee Jin‐min , Kim Kye‐ha 
Published: July 2017

AbstractMost Korean women who experience menstrual pain have reported taking pain medicine and making use of complementary alternative therapies. However, because some interventions may cause side effects, more effective pain‐relieving measures need to be identified. This study using a non‐equivalent group design, evaluated the effects of near‐infrared rays on dysmenorrhea among Korean women. The experimental group wore a near‐infrared ray abdominal belt for the duration of one menstrual cycle until the end of the menstrual period, while the control group used hot packs. The level of menstrual pain, menstrual pain duration, and pain medicine use were measured. The menstrual pain, average menstrual pain duration, and use of analgesics were reduced in the near‐infrared rays group. The results of this study indicate that the near‐infrared ray LED belt was effective in reducing menstrual pain, menstrual pain duration compared to the use of analgesics in Korean women with dysmenorrhea. Therefore, near‐infrared rays may be used to relieve menstrual pain and improve the quality of life of women with dysmenorrhea in Korea.
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study
Authors: Listyarifah D , Al‐Samadi A , Salem A , Syaify A , Salo T , Tervahartiala T , Grenier D , Nordström DC , Sorsa T , Ainola M 
Published: July 2017

ObjectiveEvidence of increased apoptosis is observed in periodontitis and may be associated with destruction of the periodontal tissue caused by the increased cell death, with the release of danger signals and subsequent stimulation of the proinflammatory processes. However, the exact mechanisms associated with these processes remain unclear. This study aimed to investigate the presence of the periodontal pathogen Treponema denticola, apoptosis, high mobility group box 1 as a damage‐associated molecular pattern, and several inflammatory markers in periodontitis and gingivitis subjects.Materials and methodsSoft tissue specimens from gingival tissues of periodontitis and gingivitis patients were used for immunohistochemical and immunofluorescence staining of T. denticola chymotrypsin‐like proteinase (CTLP), apoptosis markers, high mobility group box 1, Toll‐like receptor 4, inflammatory cell markers, and proinflammatory cytokines.ResultsTreponema denticola was detected in all periodontitis‐affected tissues. This was associated with a significant increase in the number of apoptotic cells, including macrophages, alterations in the expression of high mobility group box 1 and its receptor, and increased levels of proinflammatory cytokines compared with gingivitis.ConclusionsIn summary, the presence of T. denticola (especially its CTLP), apoptosis, high mobility group box 1, and inflammatory markers suggests their potential involvement in the pathogenesis of periodontitis.
The role of vitamin D on circulating memory T cells in children: The Generation R study
Authors: Looman Kirsten I.M. , Jansen Michelle A.E. , Voortman Trudy , van den Heuvel Diana , Jaddoe Vincent W.V. , Franco Oscar H. , van Zelm Menno C. , Moll Henriëtte A. 
Published: July 2017

AbstractBackgroundPrevious studies have demonstrated that vitamin D affects T‐cell function and maturation via the vitamin D receptor. However, no studies in children have been performed on this topic. Because most of the T‐cell memory is formed in the first 5 years of life, we aimed to determine the association between serum 25‐hydroxyvitamin D (25(OH)D) levels and numbers of circulatory naive, central memory (Tcm), and effector memory (Tem) T lymphocytes in a large population of healthy children.MethodsAmong 3189 children participating in a population‐based prospective cohort, we measured 25(OH)D levels and performed detailed immunophenotyping of naive and memory T lymphocytes at a median age of 6.0 years (95% range 5.7‐7.9). Detailed lymphocyte subsets were available in 986 children. Multivariable linear regression analyses were performed to determine the association between 25(OH)D and the maturation of T lymphocytes in children adjusted for cord blood 25(OH)D levels, herpes seropositivity, sociodemographic and lifestyle confounders. Furthermore, multivariable logistic regression analyses were performed to determine associations between 25(OH)D and childhood infections.ResultsHigher 25(OH)D levels were associated with higher numbers of Tem lymphocytes. Every 10 nmol/L higher 25(OH)D was associated with 2.20% (95% CI 0.54‐3.89; P=.009) higher CD4TemRA, 1.50% (95% CI 0.38‐2.62; P=.008) higher CD4TemRO, and 1.82% (95% CI 0.11‐3.56; P=.037) higher CD8TemRA cell numbers. Generally, stronger associations were observed among boys. 25(OH)D levels were not significantly associated with naive, Tcm cell numbers, herpes seropositivity, or URTIs.ConclusionsOur results suggest that vitamin D enhances cellular immunity in young children.
Complete Genome Sequence of the Lytic Giant Bacteriophage pT24 Infecting
Tenacibaculum
spp., Isolated from a Shrimp Culture Pond
Authors: Khoa Ho Viet , Midorikawa Yuki , Uchino Tsubasa , Nakai Toshihiro , Kato Goshi , Kondo Hidehiro , Hirono Ikuo , Labaiden Matthura , Direkbusarakom Sataporn , Sano Motohiko 
Published: July 2017

ABSTRACT

The lytic bacteriophage pT24, which infects
Tenacibaculum
spp., was isolated from the water of a whiteleg shrimp (
Litopenaeus vannamei
) culture pond in Thailand. This giant bacteriophage with myovirus morphology comprised 234,670 bp with 296 predicted genes.
Draft Genome Sequences of the Antarctic Endolithic Fungi
Rachicladosporium antarcticum
CCFEE 5527 and
Rachicladosporium
sp. CCFEE 5018
Authors: Coleine Claudia , Masonjones Sawyer , Selbmann Laura , Zucconi Laura , Onofri Silvano , Pacelli Claudia , Stajich Jason E. 
Published: July 2017

ABSTRACT

The draft genome sequences of
Rachicladosporium antarcticum
CCFEE 5527 and
Rachicladosporium
sp. CCFEE 5018 are the first sequenced genomes from this genus, which comprises rock-inhabiting fungi. These endolithic strains were isolated from inside rocks collected from the Antarctic Peninsula and Battleship Promontory (McMurdo Dry Valleys), Antarctica, respectively.
First Complete Genomic Sequence of a Rabies Virus from the Republic of Tajikistan Obtained Directly from a Flinders Technology Associates Card
Authors: Goharriz H. , Marston D. A. , Sharifzoda F. , Ellis R. J. , Horton D. L. , Khakimov T. , Whatmore A. , Khamroev K. , Makhmadshoev A. N. , Bazarov M. , Fooks A. R. , Banyard A. C. 
Published: July 2017

ABSTRACT
A brain homogenate derived from a rabid dog in the district of Tojikobod, Republic of Tajikistan, was applied to a Flinders Technology Associates (FTA) card. A full-genome sequence of rabies virus (RABV) was generated from the FTA card directly without extraction, demonstrating the utility of these cards for readily obtaining genetic data.
Draft Genome Sequence of Escherichia coli K-12 (ATCC 10798)
Authors: Dimitrova Daniela , Engelbrecht Kathleen C. , Putonti Catherine , Koenig David W. , Wolfe Alan J. 
Published: July 2017

ABSTRACT

Here, we present the draft genome sequence of
Escherichia coli
ATCC 10798.
E. coli
ATCC 10798 is a K-12 strain, one of the most well-studied model microorganisms. The size of the genome was 4,685,496 bp, with a G+C content of 50.70%. This assembly consists of 62 contigs and the F plasmid.
Draft Genome Sequence of an IMP-7-Producing Pseudomonas aeruginosa Bloodstream Infection Isolate from Australia
Authors: McCarthy K. L. , Jennison A. , Wailan A. M. , Paterson D. L. 
Published: July 2017

ABSTRACT

IMP-7 is one of the two IMP-type carbapenemases that in
Pseudomonas aeruginosa
are not limited to a geographic area, but it has not been previously reported in the Australian setting. We report here the draft genome sequence of an Australian
P. aeruginosa
bloodstream infection isolate that contains IMP-7.
Major adverse events and atrial tachycardia in Ebstein’s anomaly predicted by cardiovascular magnetic resonance
Authors: Rydman Riikka , Shiina Yumi , Diller Gerhard-Paul , Niwa Koichiro , Li Wei , Uemura Hideki , Uebing Anselm , Barbero Umberto , Bouzas Beatriz , Ernst Sabine , Wong Tom , Pennell Dudley J , Gatzoulis Michael A , Babu-Narayan Sonya V 
Published: July 2017

ObjectivesPatients with Ebstein’s anomaly of the tricuspid valve (EA) are at risk of tachyarrhythmia, congestive heart failure and sudden cardiac death. We sought to determine the value of cardiovascular magnetic resonance (CMR) for predicting these outcomes.MethodsSeventy-nine consecutive adult patients (aged 37±15 years) with unrepaired EA underwent CMR and were followed prospectively for a median 3.4 (range 0.4–10.9) years for clinical outcomes, namely major adverse cardiovascular events (MACEs: sustained ventricular tachycardia/heart failure hospital admission/cardiac transplantation/death) and first-onset atrial tachyarrhythmia (AT).ResultsCMR-derived variables associated with MACE (n=6) were right ventricular (RV) or left ventricular (LV) ejection fraction (EF) (HR 2.06, 95% CI 1.168 to 3.623, p=0.012 and HR 2.35, 95% CI 1.348 to 4.082, p=0.003, respectively), LV stroke volume index (HR 2.82, 95% CI 1.212 to 7.092, p=0.028) and cardiac index (HR 1.71, 95% CI 1.002 to 1.366, p=0.037); all remained significant when tested solely for mortality. History of AT (HR 11.16, 95% CI 1.30 to 95.81, p=0.028) and New York Heart Association class >2 (HR 7.66, 95% CI 1.54 to 38.20, p=0.013) were also associated with MACE; AT preceded all but one MACE, suggesting its potential role as an early marker of adverse outcome (p=0.011).CMR variables associated with first-onset AT (n=17; 21.5%) included RVEF (HR 1.55, 95% CI 1.103 to 2.160, p=0.011), total R/L volume index (HR 1.18, 95% CI 1.06 to 1.32, p=0.002), RV/LV end diastolic volume ratio (HR 1.55, 95% CI 1.14 to 2.10, p=0.005) and apical septal leaflet displacement/total LV septal length (HR 1.03, 95% CI 1.00 to 1.07, p=0.041); the latter two combined enhanced risk prediction (HR 6.12, 95% CI 1.67 to 22.56, p=0.007).ConclusionCMR-derived indices carry prognostic information regarding MACE and first-onset AT among adults with unrepaired EA. CMR may be included in the periodic surveillance of these patients.
Fostering Rural Financial Services through Technology: The Case of FINO PayTech
Authors: Maitra Debasish , Upadhyay Parijat 
Published: July 2017

The case depicts a situation faced by a company in the business of financial inclusion services. FINO PayTech Limited (popularly known as FINO) was the first mover in the blue ocean of financial inclusion business in India. It is quoted as the world’s largest banking agent manager. Formed in Mumbai in 2006 with the mission to solve problem of financial exclusion, FINO entered the market riding on the biometric smartcard and hand held devices technology and had since grown exponentially. It served more than 64 million end customers all across India adding average of one million new customers to the formal financial system every month. FINO’s uniqueness came from factors such as diversified product offering (which ranges from savings, credit, payment services, remittances, insurance, financial literacy, and so on), a robust technology, a dedicated channel of bandhus (banking correspondents/agents) and mature processes. The top leadership envisaged that FINO could not remain limited to savings and withdrawals activity if it had to reach many more million customers. The credit and micro insurance services had to be provided at the doorstep of the people and only then could FINO possibly project itself as a multi-product delivery company and that’s the challenge management was encountering when scaling up in a constrained regulatory framework.
Mineralogy, geochemistry and geochronology of mafic magmatic enclaves and their significance in evolution of Nongpoh granitoids, Meghalaya, NE India
Authors: Sadiq Mohd. , Umrao Ravi K. , Sharma B. B. , Chakraborti S. , Bhattacharyya S. , Kundu A. 
Published: July 2017

Abstract
The Cambrian Nongpoh granitoids, intrusive into the Precambrian gneissic complex and metasediments of the Shillong Group, represent a major phase of granitic magmatism in the Shillong Plateau. The Nongpoh granitoids comprise diorite, granodiorite, porphyritic and grey granites. Porphyritic granite is the dominant lithology exposed in the Nongpoh granitoids, and contains three types of enclaves, viz. xenoliths of gneissic rocks, dark grey porphyry and biotite-rich microgranular enclaves. The mafic magmatic enclaves (MMEs) of various dimensions and shapes, including rounded, ellipsoidal, rectangular, angular to subangular, and stretched bodies, were produced by evolving nature and contrasting kinematics of interacting felsic and mafic magmas. The biotite-rich enclaves are due to the injection of syn-magmatic mafic dykes in felsic magma. The various textural assemblages and sub-linear variations between silica and major oxides, chemical mixing and element diffusion suggest that multistage magma hybridization was the key process during the evolution of the Nongpoh granitoids. The 501 Ma age obtained by chemical (U–Th–Pb) dating of monazite in MME ascertained the age of the magma hybridization event in the Nongpoh granitoids, which is equivalent to the igneous activity at 500 Ma during the amalgamation of Eastern Gondwana.
Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox
Authors: Yang Jun , Milasta Sandra , Hu Dongli , AlTahan Alaa M. , Interiano Rodrigo B. , Zhou Junfang , Davidson Jesse , Low Jonathan , Lin Wenwei , Bao Ju , Goh Pollyanna , Nathwani Amit C. , Wang Ruoning , Wang Yingdi , Ong Su Sien , Boyd Vincent A. , Young Brandon , Das Sourav , Shelat Anang , Wu Yinan , Li Zhenmei , Zheng Jie J. , Mishra Ashutosh , Cheng Yong , Qu Chunxu , Peng Junmin , Green Douglas R. , White Stephen , Guy R. Kiplin , Chen Taosheng , Davidoff Andrew M. 
Published: July 2017

Abstract
Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone demethylases influence the viability and poor prognosis of neuroblastoma cells, where MYC is often overexpressed. We also identified the approved small-molecule antifungal agent ciclopirox as a novel pan-histone demethylase inhibitor. Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC function. Accordingly, ciclopirox inhibited Myc signaling in parallel with mitochondrial oxidative phosphorylation, resulting in suppression of neuroblastoma cell viability and inhibition of tumor growth associated with an induction of differentiation. Our findings provide new insights into epigenetic regulation of MYC function and suggest a novel pharmacologic basis to target histone demethylases as an indirect MYC-targeting approach for cancer therapy. Cancer Res; 77(17); 4626–38. ©2017 AACR.
The Effect of Iron Status on Risk of Coronary Artery Disease
Authors: Gill Dipender , Del Greco M. Fabiola , Walker Ann P. , Srai Surjit K.S. , Laffan Michael A. , Minelli Cosetta 
Published: July 2017

Objective—
Iron status is a modifiable trait that has been implicated in cardiovascular disease. This study uses the Mendelian randomization technique to investigate whether there is any causal effect of iron status on risk of coronary artery disease (CAD).

Approach and Results—

A 2-sample Mendelian randomization approach is used to estimate the effect of iron status on CAD risk. Three loci (rs1800562 and rs1799945 in the
HFE
gene and rs855791 in
TMPRSS6
) that are each associated with serum iron, transferrin saturation, ferritin, and transferrin in a pattern suggestive of an association with systemic iron status are used as instruments. SNP (single-nucleotide polymorphism)-iron status association estimates are based on a genome-wide association study meta-analysis of 48 972 individuals. SNP-CAD estimates are derived by combining the results of a genome-wide association study meta-analysis of 60 801 CAD cases and 123 504 controls with those of a meta-analysis of 63 746 CAD cases and 130 681 controls obtained from Metabochip and genome-wide association studies. Combined Mendelian randomization estimates are obtained for each marker by pooling results across the 3 instruments. We find evidence of a protective effect of higher iron status on CAD risk (iron odds ratio, 0.94 per SD unit increase; 95% confidence interval, 0.88–1.00;
P
=0.039; transferrin saturation odds ratio, 0.95 per SD unit increase; 95% confidence interval, 0.91–0.99;
P
=0.027; log-transformed ferritin odds ratio, 0.85 per SD unit increase; 95% confidence interval, 0.73–0.98;
P
=0.024; and transferrin odds ratio, 1.08 per SD unit increase; 95% confidence interval, 1.01–1.16;
P
=0.034).

Conclusions—
This Mendelian randomization study supports the hypothesis that higher iron status reduces CAD risk. These findings may highlight a therapeutic target.
Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016
Authors: Wang Haoran , Peng Geng , Bai Jing , He Bing , Huang Kecheng , Hu Xinrong , Liu Dongliang 
Published: July 2017

Background

Several studies have suggested that cytomegalovirus infection is likely associated with an increased relative risk of cardiovascular disease (
CVD
); however, the results are inconsistent. We aimed to provide a systematic review and meta‐analysis of community‐based prospective studies assessing the association between cytomegalovirus infection and relative risk of
CVD
.

Methods and Results

We searched Medline and
EMBASE
to retrieve prospective studies that reported risk estimates of the association between cytomegalovirus infection and relative risk of
CVD
. The search yielded 10 articles including a total of 34 564 participants and 4789
CVD
patients. Overall, exposure to cytomegalovirus infection was associated with a 22% (relative risk: 1.22, 95%
CI
: 1.07–1.38,
P
=0.002) increased relative risk of future
CVD
. We estimated that 13.4% of
CVD
incidence could be attributable to cytomegalovirus infection.

Conclusions

In conclusion, cytomegalovirus infection is associated with a significantly increased relative risk of
CVD
.
Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function
Authors: Molnar Amber O. , Eddeen Anan Bader , Ducharme Robin , Garg Amit X. , Harel Ziv , McCallum Megan K. , Perl Jeffrey , Wald Ron , Zimmerman Deborah , Sood Manish M. 
Published: July 2017

Background
Early evidence suggests proteinuria is independently associated with incident atrial fibrillation (AF). We sought to investigate whether the association of proteinuria with incident AF is altered by kidney function.

Methods and Results

Retrospective cohort study using administrative healthcare databases in Ontario, Canada (2002–2015). A total of 736 666 patients aged ≥40 years not receiving dialysis and with no previous history of AF were included. Proteinuria was defined using the urine albumin‐to‐creatinine ratio (ACR) and kidney function by the estimated glomerular filtration rate (eGFR). The primary outcome was time to AF. Cox proportional models were used to determine the hazard ratio for AF censored for death, dialysis, kidney transplant, or end of follow‐up. Fine and Grey models were used to determine the subdistribution hazard ratio for AF, with death as a competing event. Median follow‐up was 6 years and 44 809 patients developed AF. In adjusted models, ACR and eGFR were associated with AF (
P
<0.0001). The association of proteinuria with AF differed based on kidney function (ACR × eGFR interaction,
P
<0.0001). Overt proteinuria (ACR, 120 mg/mmol) was associated with greater AF risk in patients with intact (eGFR, 120) versus reduced (eGFR, 30) kidney function (adjusted hazard ratios, 4.5 [95% CI, 4.0–5.1] and 2.6 [95% CI, 2.4–2.8], respectively; referent ACR 0 and eGFR 120). Results were similar in competing risk analyses.

Conclusions
Proteinuria increases the risk of incident AF markedly in patients with intact kidney function compared with those with decreased kidney function. Screening and preventative strategies should consider proteinuria as an independent risk factor for AF.