bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training Physical Therapists in Person‐Centered Practice for People With Osteoarthritis: A Qualitative Case Study
Authors: Lawford Belinda J. , Delany Clare , Bennell Kim L. , Bills Caroline , Gale Janette , Hinman Rana S. 
Published: July 2017

ObjectiveTo explore physical therapists’ experiences with, and the impacts of, a training program in person‐centered practice to support exercise adherence in people with knee osteoarthritis.MethodsThis was a qualitative case study using semi‐structured interviews, nested within a clinical trial. Eight Australian physical therapists were interviewed before, and after, training in person‐centered practice for people with knee osteoarthritis. Training involved a 2‐day workshop, skills practice, and audit of 8 consultations with 4 patients (per therapist), and a final single‐day workshop for audit feedback and consolidation. Semi‐structured interviews were audio‐recorded and transcribed verbatim. Data were thematically analyzed.ResultsThree pretraining themes arose regarding usual communication style, definitions of person‐centered care, and sharing exercise adherence responsibility. Three themes related to the training experience emerged: learning a new language, challenging conceptions of practice, and putting it into practice. Post‐training, 3 themes arose regarding new knowledge deepening understanding of person‐centered care, changing beliefs about sharing responsibilities, and changed conceptions of role.ConclusionAlthough physical therapists found training overwhelming initially as they realized the limitations of their current knowledge and clinical practice, they felt more confident and able to provide person‐centered care to people with knee osteoarthritis by the end of training. Training in structured person‐centered methodology that provides opportunity for skills practice with patients using a restructured consultation framework can change physical therapists’ beliefs about their roles when managing patients with osteoarthritis and positively impact their clinical practice.
Eine Brücke zwischen industriellen und wohldefinierten Trägerkatalysatoren
Authors: Copéret Christophe , Allouche Florian , Chan Ka Wing , Conley Matthew P. , Delley Murielle F. , Fedorov Alexey , Moroz Ilia B. , Mougel Victor , Pucino Margherita , Searles Keith , Yamamoto Keishi , Zhizhko Pavel A. 
Published: July 2017

AbstractViele industrielle Katalysatoren enthalten isolierte Metallzentren an der Oberfläche von Oxidträgern. Derartige Katalysatoren werden seit über 40 Jahren bei verschiedensten Verfahren verwendet – die Struktur ihrer katalytischen Zentren bleibt aber bis heute nur ungenügend verstanden. Dieser Aufsatz zeigt, wie mit metallorganischer Oberflächenchemie (SOMC) Oberflächenzentren mit gut definierten Strukturen erzeugt werden können, und beschreibt die Beschaffenheit aktiver Zentren in industriellen Katalysatoren, insbesondere für die Herstellung und Umwandlung von Olefinen.
Bridging the Gap between Industrial and Well‐Defined Supported Catalysts
Authors: Copéret Christophe , Allouche Florian , Chan Ka Wing , Conley Matthew P. , Delley Murielle F. , Fedorov Alexey , Moroz Ilia B. , Mougel Victor , Pucino Margherita , Searles Keith , Yamamoto Keishi , Zhizhko Pavel A. 
Published: July 2017

AbstractMany industrial catalysts contain isolated metal sites on the surface of oxide supports. Although such catalysts have been used in a broad range of processes for more than 40 years, there is often a very limited understanding about the structure of the catalytically active sites. This Review discusses how surface organometallic chemistry (SOMC) engineers surface sites with well‐defined structures and provides insight into the nature of the active sites of industrial catalysts; the Review focuses in particular on olefin production and conversion processes.
Pyridine‐Fused Bis(Norcorrole) through Hantzsch‐Type Cyclization: Enhancement of Antiaromaticity by an Aromatic Bridge
Authors: Li Xiaofang , Meng Yankui , Yi Pinggui , Stępień Marcin , Chmielewski Piotr J. 
Published: July 2017

AbstractA non‐catalytic condensation of NiII β‐aminonorcorrole with aryl aldehydes is shown to produce a family of pyrromethane dimers that undergo deaminative cyclization to yield pyridine‐fused bis(norcorrole)s comprising two antiaromatic macrocycles communicating by an aromatic moiety. The new compounds were characterized by spectroscopic, structural, and electrochemical methods supported by DFT calculations, all of which revealed unexpected antiaromaticity enhancement in the fused system.
Experimental analysis and modeling of local ageing effects during laser sintering of polyamide 12 in regard to individual thermal histories
Authors: Josupeit Stefan , Schmid Hans‐Joachim 
Published: July 2017

ABSTRACTPolymer laser sintering (LS) is an important additive manufacturing (AM) technology. Individual and complex parts are directly produced from CAD data without the need of specific tools. The raw material is a polymer powder, which is deposited layerwise and melted selectively with a laser. Built parts are embedded in residual unmolten powder, the so‐called part cake, which undergoes thermal ageing effects due to the exposure to high temperatures for long times during the manufacturing process. Hence, the recyclability of the unmolten powder is limited. This article focuses on a fundamental analysis of the ageing kinetics dependent on time, temperature, and oxygen content in the gas atmosphere. A model is developed and applied to measured, position‐dependent process temperature histories to successfully predict the ageing distribution within a part cake. The results can be used to optimize the thermal process management in LS and to develop new efficient powder recycling methods. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45435.
Location or Hukou: What Most Limits Fertility of Urban Women in China?
Authors: Liang Yun , Gibson John 
Published: July 2017

AbstractChina's fertility rate is below replacement level. The government is attempting to increase this rate by relaxing the one‐child policy. China faces a possible tradeoff because further urbanization is needed to raise incomes but may reduce future fertility. We decompose China's rural–urban fertility gaps using both de facto and de jure criteria for defining the urban population. The fertility‐depressing effects of holding urban hukou are more than three times larger than effects of urban residence. Less of the rural–urban fertility gap by hukou status is due to differences in characteristics than is the case for the fertility gap by place of residence.
Creating Sydney‐Hawkesbury rock engravings: A Mangrove Mountain engraving tool
Authors: ATTENBROW VAL , KONONENKO NINA 
Published: July 2017

ABSTRACTAboriginal rock engravings of the Sydney‐Hawkesbury region on Australia's east coast were commented on by the first British colonists, but their reports and journals contain no descriptions of how they were produced. Use‐wear analysis of a basalt stone tool found on an engraving site in the Mangrove Mountain area of the NSW Central Coast supports the finder's supposition that it was a rock engraving tool. The analysis indicates the tool was used for both pecking and abrading coarse‐grained rock – actions used in creating the Sydney‐Hawkesbury rock engravings by a technique known as “conjoined‐puncturing”. An experimental study was undertaken to test the efficiency and usefulness of basalt tools in creating rock engravings and to produce wear traces for comparative functional analysis. The use‐wear analysis suggests that this tool was also used for preparing skins.
Thermosensitive Triterpenoid‐Appended Polymers with Broad Temperature Tunability Regulated by Host–Guest Chemistry
Authors: Hao Jie , Gao Yuxia , Li Ying , Yan Qiang , Hu Jun , Ju Yong 
Published: July 2017

AbstractThermoresponsive water‐soluble polymers are of great importance since they typically show a lower critical solution temperature (LCST) in aqueous media. In this research, the LCST change in broad temperature ranges of copolymers composed of natural glycyrrhetinic acid (GA)‐based methacrylate and N,N′‐dimethylacrylamides (DMAs) was investigated as a function of the concentration and the content of GA pendants. By complexation of GA pendants with β‐cyclodextrin (β‐CD), a side‐chain polypseudorotaxane was obtained, which exhibited a significant increase in the LCST of copolymers. Moreover, the precisely reversible control of the LCST behavior was realized through adding a competing guest molecule, sodium 1‐admantylcarboxylate. This work illustrates a simple and effective approach to endow water‐soluble polymers with broad temperature tunability and helps us further understand the effect of a biocompatible host–guest complementary β‐CD/GA pair on the thermoresponsive process.
Adaptive Controller Based Unified Power Flow Control for Low Power Oscillation Damping
Authors: Zeb Nadia , Khan Bilal , Ali Sahibzada Muhammad , Mehmood Chaudhry Arshad , Sajjad Rabia , Farid Umar , Bibi Ayesha 
Published: July 2017

AbstractLow frequency oscillation (LFO) within a power system is an important issue. Loss of inter‐connected machine synchronism, reactive load increase, and faults and disturbances lead to a LFO in a range between 0.1–2 Hz. LFOs limit power transfer over long transmission lines, thus degrading the quality of supply. Moreover, conventional local control, namely, the power system stabilizer, is unable to mitigate LFOs. Furthermore, continuation of LFOs will lead to complete system collapse (blackouts). Considering the above issues, there is a pressing need to incorporate advanced control systems to damp inter‐area LFOs. We propose an adaptive‐supplementary unified power flow control (UPFC) for two inter‐connected areas of a power system. Our work is novel in its design of a supplementary control system using a neural network based on a feedback linearization auto‐regression average model. With the above proposed control scheme, the stability of power system is enhanced in terms of: (1) effective LFO damping; (2) power transfer; (3) improvement in the dynamic parameters of the system; (4) active and reactive power support; (5) loss minimization; and (6) demand–supply management. To justify these claims, we implement our proposed controller on a two‐area (four machine) system. Critical analysis of the system is conducted under symmetrical grid faults. The result of the proposed control scheme justifies the performance enhancement of above parameters, as per grid‐code requirements, compared with conventional a proportional integral (PI) controller.
Long‐term safety and effectiveness of levodopa‐carbidopa intestinal gel infusion
Authors: De Fabregues Oriol , Dot Joan , Abu‐Suboh Monder , Hernández‐Vara Jorge , Ferré Alex , Romero Odile , Ibarria Marta , Seoane José Luis , Raguer Nuria , Puiggros Carolina , Gómez Maria Rosa , Quintana Manuel , Armengol Josep Ramon , Alvarez‐Sabín José 
Published: July 2017

AbstractIntroductionLevodopa‐carbidopa intestinal gel (LCIG) infusion has demonstrated to improve motor fluctuations. The aim of this study is to assess the long‐term safety and effectiveness of LCIG infusion in advanced Parkinson's disease (PD) patients with motor fluctuations and its effect in nonmotor symptoms.MethodsAdverse events (AE) and their management, clinical motor, and nonmotor aspects were assessed up to 10 years. Thirty‐seven patients were treated with LGIC; in three subsets of patients, specific batteries of tests were used to assess cognitive and behavior assessment for 6 months, quality of sleep for 6 months, and quality of life and caregiver burden for 1 year.ResultsThere was a high number of AE, but manageable, most of mild and moderate severity. All patients experienced significant improvement in motor fluctuations with a reduction in mean daily off time of 4.87 hr after 3 months (n = 37) to 6.25 hr after 9 years (n = 2). Diskynesias remained stables in 28 patients (75.7%) and improved in 5 patients (13.5%). There was no neuropsychological deterioration, but an improvement in attentional functions, voluntary motor control, and semantic fluency. Quality of sleep did not worsen, and there was an improvement in the subjective parameters, although overnight polysomnography did not change. There was a significant sustained improvement of 37% in PD‐Q39 after 3 months and to 1 year, and a significant reduction in caregiver burden of 10% after 3 months.ConclusionLCIG infusion is a safe and efficacious treatment for the control of motor fluctuations, and for improvement or nonworsening of nonmotor aspects, long‐term sustained, and feasible for use in routine care.
Creating inclusive identity narratives through participatory action research
Authors: Dutta Urmitapa 
Published: July 2017

AbstractThis paper describes the process and outcomes of Voices, a participatory action research project aimed to disrupt divisive ethnic identity narratives among youth living amidst protracted ethnic conflict. The project took place in the Garo Hills region of Northeast India, a site of protracted ethnic conflict. Moving away from crisis‐based approaches, this paper explores the conflict transformative potential of participatory action research, specifically its effectiveness in facilitating civic engagement across ethnic lines. The findings indicate that young people's involvement in the project afforded them an opportunity to engage with local community concerns outside of polarized ethnic identity narratives. This involvement facilitated three critical outcomes: engagement in social critique, reconfiguration of a more inclusive researcher identity, and adoption of a language of possibility. Based on these findings, it is argued that opportunities for critical community engagement could interrupt divisive ethnic identity narratives and provide turning points for youth to reimagine inclusive social identities.
Restoration of microRNA‐708 sensitizes ovarian cancer cells to cisplatin via IGF2BP1/Akt pathway
Authors: Qin Xuying , Sun Linlin , Wang Jing 
Published: July 2017

AbstractA previous study has shown that microRNA‐708 (miR‐708) functions as a metastasis suppressor in ovarian cancer. In this study, we aimed to explore its implication in regulating cisplatin sensitivity in ovarian cancer cells. To this end, ovarian cancer cells were transfected with miR‐708‐expressing plasmids or vector before treatment with different concentrations of cisplatin for 48 h. The 50% inhibitory concentration (IC50) value was calculated. Apoptosis was analyzed by measuring caspase‐3 activity. The target gene mediating the function of miR‐708 was identified. Ectopic expression of miR‐708 sensitized SKOV3 and A2780 cells to cisplatin, decreasing the IC50 value by two‐ to threefold. miR‐708 overexpression significantly augmented cisplatin‐induced apoptosis in ovarian cancer cells, which was coupled with increased caspase‐3 activity by two‐ to fourfold. Similarly, overexpression of miR‐708 increased the sensitivity of cisplatin‐resistant SKOV3/DDP and A2780/DDP cells to cisplatin‐induced toxicity, reducing the IC50 by three‐ and fivefold, respectively. Delivery of miR‐708 enhanced cisplatin‐induced elevation in caspase‐3 activity in both cisplatin‐resistant and parental ovarian cancer cells. Mechanistically, miR‐708 downregulated the expression of insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and suppressed Akt phosphorylation. Silencing of IGF2BP1 markedly blocked the phosphorylation of Akt. Overexpression of IGF2BP1 restored cisplatin resistance and Akt phosphorylation in miR‐708‐overexpressing ovarian cancer cells. Collectively, miR‐708 increases the susceptibility of ovarian cancer cells to cisplatin by targeting IGF2BP1 and inhibiting Akt signaling. Delivery of miR‐708 may represent a promising strategy for improving cisplatin chemotherapy.
Trifluoromethylation of a Well‐Defined Square‐Planar Aryl‐NiII Complex involving NiIII/CF3. and NiIV−CF3 Intermediate Species
Authors: Rovira Mireia , Roldán‐Gómez Steven , Martin‐Diaconescu Vlad , Whiteoak Christopher J. , Company Anna , Luis Josep M. , Ribas Xavi 
Published: July 2017

AbstractNi‐mediated trifluoromethylation of an aryl−Br bond in model macrocyclic ligands (Ln−Br) has been thoroughly studied, starting with an oxidative addition at Ni0 to obtain well‐defined aryl‐NiII‐Br complexes ([Ln−NiII]Br). Abstraction of the halide with AgX (X=OTf− or ClO4−) thereafter provides [Ln−NiII](OTf). The nitrate analogue has been obtained through a direct C−H activation of an aryl−H bond using NiII salts, and this route has been studied by X‐ray absorption spectroscopy (XAS). Crystallographic XRD and XAS characterization has shown a tight macrocyclic coordination in the aryl−NiII complex, which may hamper direct reaction with nucleophiles. On the contrary, enhanced reactivity is observed with oxidants, and the reaction of [Ln−NiII](OTf) with CF3+ sources afforded Ln−CF3 products in quantitative yield. A combined experimental and theoretical mechanistic study provides new insights into the operative mechanism for this transformation. Computational analysis indicates the occurrence of an initial single electron transfer (SET) to 5‐(trifluoromethyl)dibenzothiophenium triflate (TDTT), producing a transient L1−NiIII/CF3. adduct, which rapidly recombines to form a [L1‐NiIV‐CF3](X)2 intermediate species. A final facile reductive elimination affords L1−CF3. The well‐defined square‐planar model system studied here permits to gain fundamental knowledge on the rich redox chemistry of nickel, which is sought to facilitate the development of new Ni‐based trifluoromethylation methodologies.
Total Syntheses of Pyroclavine, Festuclavine, Lysergol, and Isolysergol via a Catalytic Asymmetric Nitro‐Michael Reaction
Authors: Bhunia Subhajit , Chaudhuri Saikat , Bisai Alakesh 
Published: July 2017

AbstractA catalytic enantioselective construction of vicinal stereocenters is reported. The reaction takes advantage of thiourea‐catalyzed intramolecular nitronate addition onto α,β‐unsaturated ester to afford exceptional levels of enantioselectivity (up to 97 % ee) with moderate diastereoselectivity (up to 4:1). Using this method, a cross‐conjugated ester was synthesized in few steps, from which a 6‐endo‐trig cyclisation led to the formation of all required functionalities for total syntheses of ergot alkaloids. The strategy not only offers first total syntheses of ergot alkaloids, festuclavine (1 c), and pyroclavine (1 e), and but also an efficient and general approach to other congeners such as, lysergol (1 b), and isolysergol (1 d).
Utilizing Palladium‐Stabilized Zwitterions for the Construction of N‐Heterocycles
Authors: Allen Benjamin D. W. , Lakeland Christopher P. , Harrity Joseph P. A. 
Published: July 2017

AbstractPd catalysis provides a convenient method for the generation of zwitterionic intermediates that offer significant opportunities for the synthesis of functionalized heterocycles. The combination of electrophilic π‐allyl Pd fragments and C‐, N‐ and O‐centered nucleophiles allows these intermediates to react with readily available substrates to furnish a range of high value products with control of chemo‐, regio‐ and stereo‐selectivity.
A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points
Authors: Martinetz Michael Christian , Rehrl Jakob , Aigner Isabella , Sacher Stephan , Khinast Johannes 
Published: July 2017

AbstractIn a continuous pharmaceutical manufacturing line the rotary tablet press was viewed as the master of control concept and defined the mass flow through the entire process. According to a conventional control concept, missing mass flow from an upstream unit operation leads to a shutdown of the tablet press. Various operating scenarios were simulated and the influence of turret speed on the tablet properties was experimentally investigated. Changes in the turret speed alter the critical process parameters dwell time and die filling time. Their influence was evaluated using two model formulations with different compaction behavior.
Highly Efficient Photocatalytic Remediation of Simulated Polycyclic Aromatic Hydrocarbons (PAHs) Contaminated Wastewater under Visible Light Irradiation by Graphene Oxide Enwrapped Ag3PO4 Composite.
Authors: Yang Xiaolong , Cai Haoyuan , Bao Mutai , Yu Jianqiang , Lu Jinren , Li Yiming 
Published: July 2017

Effective removal of polycyclic aromatic hydrocarbons (PAHs) from wastewater before their discharge into the environment is an ever pressing requirement. In this study, for the first time, simulated PAHs contaminated wastewater was photocatalytically remediated with graphene oxide (GO) enwrapped silver phosphate as visible light‐driven photocatalysts. The GO/Ag3PO4 photocatalysts exhibited superior photocatalytic activity and stability compared with pure Ag3PO4, g‐C3N4 and TiO2 (P25). The degradation efficiency of naphthalene, phenanthrene and pyrene could reach 49.7%, 100.0% and 77.9%, rspectively within 5 min irradiation. The apparent rate constants of photocatalytic degradation of 3 wt% GO/Ag3PO4 composite photocatalyst were 0.14, 1.21 and 2.46 min−1 for naphthalene, phenanthrene and pyrene, respectively. They were about 1.8, 1.5 and 2.0 times higher than that of pure Ag3PO4, and much higher than that of g‐C3N4 and TiO2. Meanwhile, the efficiencies of 44.6%, 95.2% and 83.8% were achieved for naphthalene, phenanthrene and pyrene degradation even after 5 times of recycling in the GO/Ag3PO4‐PAHs photocatalysis system. Reactive species of ∙O2− and h+ were considered as the main participants for oxidizing naphthalene, phenanthrene and pyrene.
Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein
Authors: Sakano Hitomi , Zorio Diego A. R. , Wang Xiaoyu , Ting Ying S. , Noble William S. , MacCoss Michael J. , Rubel Edwin W , Wang Yuan 
Published: July 2017

AbstractThe avian nucleus laminaris (NL) is a brainstem nucleus necessary for binaural processing, analogous in structure and function to the mammalian medial superior olive. In chickens (Gallus gallus), NL is a well‐studied model system for activity‐dependent neural plasticity. Its neurons have bipolar extension of dendrites, which receive segregated inputs from two ears and display rapid and compartment‐specific reorganization in response to unilateral changes in auditory input. More recently, fragile X mental retardation protein (FMRP), an RNA‐binding protein that regulates local protein translation, has been shown to be enriched in NL dendrites, suggesting its potential role in the structural dynamics of these dendrites. To explore the molecular role of FMRP in this nucleus, we performed proteomic analysis of NL, using micro laser capture and liquid chromatography tandem mass spectrometry. We identified 657 proteins, greatly represented in pathways involved in mitochondria, translation and metabolism, consistent with high levels of activity of NL neurons. Of these, 94 are potential FMRP targets, by comparative analysis with previously proposed FMRP targets in mammals. These proteins are enriched in pathways involved in cellular growth, cellular trafficking and transmembrane transport. Immunocytochemistry verified the dendritic localization of several proteins in NL. Furthermore, we confirmed the direct interaction of FMRP with one candidate, RhoC, by in vitro RNA binding assays. In summary, we provide a database of highly expressed proteins in NL and in particular a list of potential FMRP targets, with the goal of facilitating molecular characterization of FMRP signaling in future studies.