bluuebunny/crossref_metadata_2025_split huggingface dataset:
All-Inside Versus Inside-Out Meniscal Repair With Concurrent Anterior Cruciate Ligament Reconstruction: A Meta-regression Analysis
Authors: Westermann Robert W. , Duchman Kyle R. , Amendola Annunziato , Glass Natalie , Wolf Brian R. 
Published: April 2016

Background: Meniscal tears are frequently repaired during anterior cruciate ligament reconstruction (ACLR). Purpose: To systematically evaluate differences in clinical failures between all-inside and inside-out meniscal repairs performed during ACLR. Study Design: Meta-analysis; Level of evidence, 4. Methods: A systematic review was perfomed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases queried included MEDLINE, CINAHL, EMBASE, and Cochrane Central Register of Controlled Trials. All English-language studies reporting failure rates after meniscal repair with either the all-inside or inside-out technique performed in conjunction with ACLR were identified between 1980 and 2015. Studies with a minimum 2-year follow-up were included. Reported outcomes, clinical meniscal repair failures, and complications were assessed. Studies were weighted according to the size of the clinical series and mean follow-up length. Inverse-variance–weighted mixed models were used to evaluate whether there was a significant difference in pooled reoperation rates between repair techniques. Results: In total, 21 studies met inclusion criteria. Of these, 13 studies reported outcomes after all-inside repair, and 10 studies reported outcomes after inside-out repair (2 studies reported both). A total of 1126 patients were included in the analysis. The mean (±SD) follow-up for all-inside repair was 58.64 ± 22.24 months versus 76.25 ± 31.69 months for inside-out repair ( P = .13). The clinical failure rate for all-inside meniscal repair performed concurrently with ACLR was 16% (121/744) compared with 10% (39/382) for inside-out repair, and this was found to be significant ( P = .016). Implant irritation and device migration were the most common complications reported for all-inside repair; complication rates did not differ between the groups. Conclusion: There may be fewer early clinical failures when the inside-out technique is utilized for meniscal repair at the time of concomitant ACLR. Additional long-term studies will be useful to determine the operative success of these repairs over time.
Military Occupational Outcomes in Canadian Armed Forces Personnel with and without Deployment-Related Mental Disorders
Authors: Boulos David , Zamorski Mark A. 
Published: April 2016

Objective: Mental disorders are common in military organizations, and these frequently lead to functional impairments that can interfere with duties and lead to costly attrition. In Canada, the military mental health system has received heavy investment to improve occupational outcomes. We investigated military occupational outcomes of diagnosed mental disorders in a cohort of 30,513 personnel who deployed on the Afghanistan mission. Methods: Cohort members were military personnel who deployed on the Afghanistan mission from 2001 to 2008. Mental disorder diagnoses and their attribution to the Afghanistan mission were ascertained via medical records in a stratified random sample ( n = 2014). Career-limiting medical conditions (that is, condition-associated restrictions that reliably lead to medically related attrition) were determined using administrative data. Outcomes were assessed from first Afghanistan-related deployment return. Results: At 5 years of follow-up, the Kaplan-Meier estimated cumulative fraction with career-limiting medical conditions was 40.9% (95% confidence interval [CI] 35.5 to 46.4) among individuals with Afghanistan service–related mental disorders (ARMD), 23.6% (CI 15.5 to 31.8) with other mental disorders, and 11.1% (CI 8.9 to 13.3) without mental disorders. The adjusted Cox regression hazard ratios for career-limiting medical condition risk were 4.89 (CI 3.85 to 6.23) among individuals with ARMD and 2.31 (CI 1.48 to 3.60) with other mental disorders, relative to those without mental disorders. Conclusions: Notwithstanding the Canadian military’s mental health system investments, mental disorders (particularly ARMD) still led to a high risk of adverse military occupational outcomes. Such investments have intrinsic value but may not translate into reduced medically related attrition without improvements in prevention and treatment effectiveness.
The National Practice Patterns of Venous Thromboembolism Prophylaxis Post-Cardiothoracic Surgery
Authors: Mathew Sheena E. , Beavers Craig J. , McNeely Elizabeth 
Published: April 2016

Background: The rates of venous thromboembolism (VTE) post-cardiothoracic surgery are not well understood. The american college of chest physicians (CHEST) guidelines report weak recommendations for starting VTE prophylaxis post-cardiothoracic surgery. It is suspected that due to the increase in bleed risk, postsurgery initiation of pharmacologic VTE prophylaxis is limited. Objective: The study sought to investigate the use of VTE prevention in US hospitals performing cardiac surgery and the use of mechanical/chemical prophylaxis postoperatively. Methods: This is a multicenter survey distributed to cardiac hospitals in the United States. The survey was distributed through 3 separate listservs. Data were analyzed utilizing descriptive statistics. Results: The majority of the hospitals were academic and/or community and completed coronary artery bypass graft (CABG), valve replacement (mitral/aortic/tricuspid), and aortic repair. It was common for hospitals to start mechanical and pharmacologic prophylaxis post-cardiothoracic surgery on postoperative day (POD) 1 to 2. The anticoagulation most commonly used consisted of unfractionated heparin. Conclusions: The majority of the institutions are initiating therapy POD 1 to 2 with both mechanical and chemical prophylaxis. The full impact of early initiation of VTE prophylaxis is unknown, and more studies are needed to assess the true risks/benefits of these practices.
A Program to Increase Research Productivity Among Hospital Pharmacists
Authors: Nazer Lama H. , Tuffaha Haitham , Jaddoua Saad 
Published: April 2016

Objective: To describe the development, implementation, and outcomes of a structured research training program that aimed to increase the research productivity among hospital pharmacists. Methods: The program was conducted in a step-wise approach and started with educational sessions on evidence-based medicine and research methods. After about a year, pharmacists were trained and mentored on how to conduct and publish a research project. We evaluated the number of research projects and publications for the pharmacy department before and after the implementation of the program. Results: In the 5 years prior to implementing the program, there were a total of 4 institutional review board (IRB) proposals, 4 abstracts, and 2 manuscripts, which had pharmacists as primary investigators. After 5 years of running the program, there were 24 pharmacist-initiated research proposals submitted to the IRB, 29 abstracts, and 11 published manuscripts. The major challenges were the lack of sufficient time and the extensive training and mentorship required. Conclusion: Implementing a structured pharmacy research program at a hospital setting was feasible and was associated with an increase in the pharmacist-led research and publications. The success of such a program requires training and mentorship, strong commitment, and administrative support.
Class-imbalanced subsampling lasso algorithm for discovering adverse drug reactions
Authors: Ahmed Ismaïl , Pariente Antoine , Tubert-Bitter Pascale 
Published: April 2016

Background All methods routinely used to generate safety signals from pharmacovigilance databases rely on disproportionality analyses of counts aggregating patients’ spontaneous reports. Recently, it was proposed to analyze individual spontaneous reports directly using Bayesian lasso logistic regressions. Nevertheless, this raises the issue of choosing an adequate regularization parameter in a variable selection framework while accounting for computational constraints due to the high dimension of the data. Purpose Our main objective is to propose a method, which exploits the subsampling idea from Stability Selection, a variable selection procedure combining subsampling with a high-dimensional selection algorithm, and adapts it to the specificities of the spontaneous reporting data, the latter being characterized by their large size, their binary nature and their sparsity. Materials and method Given the large imbalance existing between the presence and absence of a given adverse event, we propose an alternative subsampling scheme to that of Stability Selection resulting in an over-representation of the minority class and a drastic reduction in the number of observations in each subsample. Simulations are used to help define the detection threshold as regards the average proportion of false signals. They are also used to compare the performances of the proposed sampling scheme with that originally proposed for Stability Selection. Finally, we compare the proposed method to the gamma Poisson shrinker, a disproportionality method, and to a lasso logistic regression approach through an empirical study conducted on the French national pharmacovigilance database and two sets of reference signals. Results Simulations show that the proposed sampling strategy performs better in terms of false discoveries and is faster than the equiprobable sampling of Stability Selection. The empirical evaluation illustrates the better performances of the proposed method compared with gamma Poisson shrinker and the lasso in terms of number of reference signals retrieved.
Autonomy and dignity of patients with dementia: Perceptions of multicultural caretakers
Authors: Bentwich Miriam Ethel , Dickman Nomy , Oberman Amitai 
Published: April 2016

Background: A key message in the World Health Organization’s report on dementia emphasizes the need to improve public and professional attitudes to dementia and its understanding, while acknowledging the fact that the workforce in dementia care is becoming increasingly diverse culturally. Objectives: To explore possible differences among formal caretakers from varied cultural background in their attitudes toward the autonomy and human dignity of patients with dementia. Research design: Semi-structured interviews and content analysis, utilizing two fictional vignettes for eliciting caretakers’ attitudes toward dignity and autonomy of their patients. Participants and context: A total of 20 formal caretakers of patients with dementia from three different cultural groups in Israel (“Sabras,” “Arabs,” and “Russians”), working in nursing homes and a hospital. Ethical consideration: Approvals of relevant research ethics committees were obtained and followed. Findings: In comparison with the other groups, most Arab caretakers offer markedly richer perceptions of human dignity and autonomy. Their human dignity’s conceptualization emphasizes “person-centered approach,” and their perception of patients’ autonomy includes provision of explanations and preservation and encouragement of independence. Discussion: The differences found in the attitudes toward the meaning of autonomy and human dignity between the Arab caretakers and the other caretakers stand in contrast to previous studies regarding human dignity, emphasizing the common nature of these attitudes. Offering a linkage (theoretical and empirical) between the Arab perceptions of dignity and autonomy, the study strengthen and further the importance attributed in existing literature to person-centered care in enhancing the quality of care for patients with dementia. Conclusion: The conceptualization of human dignity may vary among different cultural groups. It may also influence the extent to which the caretaker holds a full-fledged perception of the patients’ autonomy.
The emotion: A crucial component in the care of critically ill patients
Authors: Acebedo-Urdiales Maria Sagrario , Jiménez-Herrera Maria , Ferré-Grau Carme , Font-Jiménez Isabel , Roca-Biosca Alba , Bazo-Hernández Leticia , Castillo-Cepero M José , Serret-Serret Maria , Medina-Moya José Luis 
Published: April 2016

Background: The acquisition of experience is a major concern for nurses in intensive care units. Although the emotional component of the clinical practice of these nurses has been widely studied, greater examination is required to determine how this component influences their learning and practical experience. Objective: To discover the relationships between emotion, memory and learning and the impacts on nursing clinical practice. Research design: This is a qualitative phenomenological study. The data were collected from open, in-depth interviews. A total of 22 intensive care unit nurses participated in this research between January 2012 and December 2014. Ethical considerations: The School of Nursing Ethics Committee approved the study, which complied with ethical principles and required informed consent. Findings: We found a clear relationship between emotion, memory and the acquisition of experience. This relationship grouped three dimensions: (1) satisfaction, to relieve the patient’s pain or discomfort, give confidence and a sense of security to the patient, enable the presence of family members into the intensive care unit and provide family members with a realistic view of the patient’s situation; (2) error experience, which nurses feel when a patient dies, when they fail to accompany a patient in his or her decision to abandon the struggle to live or when they fail to lend support to the patient’s family; and (3) the feel bad–feel good paradox, which occurs when a mistake in the patient’s care or handling of his or her family is repaired. Conclusion: Emotion is a capacity that impacts on nurses’ experience and influences improvements in clinical practice. Recalling stories of satisfaction helps to reinforce good practice, while recalling stories of errors helps to identify difficulties in the profession and recognise new forms of action. The articulation of emotional competencies may support the development of nursing ethics in the intensive care unit to protect and defend their patients and improve their relationships with families in order to maximise the potential for patient care.
The time course of within and between-language interference in bilinguals
Authors: Incera Sara , McLennan Conor T 
Published: April 2016

Purpose: Recent research has provided support for linguistic coactivation, the view that the two languages of a bilingual are simultaneously active. Importantly, even if the system is fundamentally nonselective, the two languages of a bilingual can be activated to different degrees. The main contribution of the present paper is to empirically test what “different degrees of activation” really means. Differences could emerge in the timing or the magnitude of language activation. Methodology: Most of the research to date has been based on experiments using reaction times. In the present experiment participants responded to a bilingual Stroop task using a computer mouse. We argue that mouse tracking can provide new insights into the temporal dynamics of cognitive processes. Data and analysis: We used a series of t-tests to analyze participants’ mouse trajectories ( n = 20). We compared the x-coordinates over time for each of the four experimental conditions (Congruent-Within, Congruent-Between, Incongruent-Within, Incongruent-Between) with the x-coordinates over time for the control trajectory. Findings: Differences in the timing, but not the magnitude, of interference are at the root of the differential effects within and between languages. Within-language interference emerged 80 ms earlier than between-language interference. Originality: To our knowledge, the current experiment is the first to use the dynamic mouse-tracking paradigm to compare the time course of the two languages of a bilingual participant. Implications: The mouse-tracking paradigm can help to distinguish between the timing and the magnitude of interference, informing current theories of the bilingual mind.
Health-Related Quality of Life, Cachexia and Overall Survival After Major Upper Abdominal Surgery: A Prospective Cohort Study
Authors: Aahlin E. K. , Tranø G. , Johns N. , Horn A. , Søreide J. A. , Fearon K. C. , Revhaug A. , Lassen K. 
Published: April 2016

Background and Aims: Major upper abdominal surgery is often associated with reduced health-related quality of life and reduced survival. Patients with upper abdominal malignancies often suffer from cachexia, represented by preoperative weight loss and sarcopenia (low skeletal muscle mass) and this might affect both health-related quality of life and survival. We aimed to investigate how health-related quality of life is affected by cachexia and how health-related quality of life relates to long-term survival after major upper abdominal surgery. Materials and Methods: From 2001 to 2006, 447 patients were included in a Norwegian multicenter randomized controlled trial in major upper abdominal surgery. In this study, six years later, these patients were analyzed as a single prospective cohort and survival data were retrieved from the National Population Registry. Cachexia was derived from patient-reported preoperative weight loss and sarcopenia as assessed from computed tomography images taken within three months preoperatively. In the original trial, self-reported health-related quality of life was assessed preoperatively at trial enrollment and eight weeks postoperatively with the health-related quality of life questionnaire Short Form 36. Results: A majority of the patients experienced improved mental health-related quality of life and, to a lesser extent, deteriorated physical health-related quality of life following surgery. There was a significant association between preoperative weight loss and reduced physical health-related quality of life. No association between sarcopenia and health-related quality of life was observed. Overall survival was significantly associated with physical health-related quality of life both pre- and postoperatively, and with postoperative mental health-related quality of life. The association between health-related quality of life and survival was particularly strong for postoperative physical health-related quality of life. Conclusion: Postoperative physical health-related quality of life strongly correlates with overall survival after major upper abdominal surgery.
Surveillance Duplex Ultrasonography of Stent Grafts for Popliteal Aneurysms
Authors: Pineda Danielle M. , Troutman Douglas A. , Dougherty Matthew J. , Calligaro Keith D. 
Published: April 2016

Objective: Stent grafts, also known as covered stents, have become an increasingly acceptable treatment for popliteal artery aneurysms. However, endovascular exclusion confers lower primary patency compared to traditional open bypass and exclusion. The purpose of this study was to evaluate whether duplex ultrasonography (DU) can reliably diagnose failing stent grafts placed for popliteal artery aneurysms prior to occlusion. Methods: Between June 5, 2007, and March 11, 2014, 21 stent grafts (Viabahn; Gore, Flagstaff, Arizona) were placed in 19 patients for popliteal artery aneurysms. All patients had at least 1 follow-up duplex scan postoperatively. Mean follow-up was 28.9 months (9-93 months). Postoperative DU surveillance was performed in our Intersocietal Accreditation Commission noninvasive vascular laboratory at 1 week postprocedure and every 6 months thereafter. Duplex ultrasonography measured peak systolic velocities (PSVs) and ratio of adjacent PSVs (Vr) every 5 cm within the stent graft and adjacent arteries. Results: We retrospectively classified the following factors as “abnormal DU findings”: focal PSV > 300 cm/s, uniform PSVs < 50 cm/s throughout the graft, and Vr > 3.0. These DU criteria were derived from laboratory-specific data that we previously published on failing stent grafts placed for lower extremity occlusive disease. Four of the 21 stent grafts presented with symptomatic graft thrombosis within 6 months of a normal DU. Three of these 4 patients presented with rest pain and underwent thrombectomy (2) or vein bypass (1), and 1 elected for nonintervention for claudication. Conclusion: Our results suggest that surveillance DU using criteria established for grafts placed for occlusive disease may not be useful for predicting stent graft failure in popliteal artery aneurysms.
Treatment Outcomes and Lessons Learned From Transilluminated Powered Phlebectomy for Varicose Veins in 1034 Patients
Authors: Lin Peter H. , Matos Jesus M. , Chen Aaron , Kim Walter , Poi Mun J. , Jiang Jenny S. , Bechara Carlos F. 
Published: April 2016

Introduction: Transilluminated powered phlebectomy (TIPP) is a minimally invasive technique of varicose vein removal, which combines irrigated illumination with tumescent anesthesia for ablation of superficial varicosities and endoscopic-powered venous resection. The objective of this study was to analyze treatment outcomes of this treatment modality. Methods: A retrospective evaluation of prospectively collected data from all patients undergoing TIPP procedure for symptomatic varicose veins during a recent 12-year period was performed. Pertinent patient demographics, disease classification, perioperative complications, quality of life, and treatment outcomes were collected and analyzed. Results: A total of 1167 limbs in 1034 patients (mean age, 52.4 years) were treated during the study period. The mean procedure time was 18.4 ± 8.9 minutes (range, 6.0-82.0 minutes). The mean number of incisions for TIPP procedure was 6.3 ± 3.6. All TIPP procedures were technically successful, and no patient required conversion to hook stab phlebectomy. Fifteen (1.5%) patients developed residual or recurrent varicosities, which were treated with sclerotherapy during the follow-up period. Postoperative complications included hematoma at 2 weeks (5.8%), ecchymosis at 2 weeks (32.9%), saphenous neuropathy (0.3%), cellulitis (1.0%), and skin pigmentation (1.9%). There was no postoperative deep vein thrombosis or mortality. Conclusions: Transilluminated powered phlebectomy is an effective method for varicose vein removal and is associated with high clinical success and excellent cosmetic results. Meticulous technical steps are critical in achieving successful outcomes while minimizing complications. Technical considerations and lessons learned from our experiences are discussed in this report.