bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: A successful outcome of nadroparin calcium therapy for cerebral venous sinus thrombosis in a child with acute lymphoblastic leukemia
Authors: Xie Lichun , Xu Ye , Zhou Guichi , Chen Fen , Li Changgang , Ma Lian , Wen Feiqiu 
Published: September 2024

BackgroundThe appearance of cerebral venous sinus thrombosis (CVST) in childhood acute lymphocytic leukemia (ALL) is a rare life-threatening disease that can cause significant morbidity, neurological sequelae, and potentially poor outcomes.Case presentationWe present the case of a 13-year-old boy with ALL who developed CVST and intrinsic hemorrhage approximately 30 days after receiving chemotherapy with vincristine, dexamethasone, daunorubicin, and pegylated-asparaginase (PEG-Asp). He complained of a severe headache and then developed a generalized seizure at night. T1- and T2-weighted magnetic resonance imaging (MRI) and cerebral magnetic resonance venography sequences revealed superior sagittal sinus thrombosis and intrinsic hemorrhagic changes in the bilateral frontoparietal lobes. He received nadroparin calcium as the anticoagulant treatment and was switched to Erwinia asparaginase (Erwinia Asp) rather than PEG-Asp. Oxcarbazepine and clonazepam were started with good seizure control. Intrathecal treatment was delayed until 1 month later. Anticoagulation treatment was stopped for 24 h before and 6 h after lumbar puncture. Platelet transfusion was administered to ensure the platelet count remained at &gt;50 × 109/L. Oral acetazolamide (500–1,000 mg, daily) was administered to relieve headache and reduce intracranial pressure. Three months later, brain MRI showed a complete resolution of or significant improvement in the filling defect. Nadroparin calcium was administered for 1 week after switching to Erwinia Asp to prevent clot recurrence. He completed the 6-month chemotherapy and is doing well with no neurological sequelae and no recurrence of bleeding or thrombosis.ConclusionsNadroparin calcium therapy appears to be safe and effective for pediatric CVST with ALL. The reintroduction of Erwinia Asp should be accompanied by anticoagulant therapy with nadroparin calcium.
Combination of Youhua Kuijie Prescription and sulfasalazine can alleviate experimental colitis via IL-6/JAK2/STAT3 pathway
Authors: Tang Lili , Liu Yuedong , Tao Hongwu , Feng Wenzhe , Ren Cong , Shu Yuping , Luo Ruijuan , Wang Xiangyi 
Published: September 2024

IntroductionYouhua Kuijie prescription (YHKJ) is a hospital preparation that is composed of nine kinds of herbs. Sulfasalazine (SASP) is widely used as a first-line clinical treatment for UC. Traditional Chinese medicine and Western medicine have their own advantages in the treatment of UC, and the mechanism of YHKJ combined with SASP in the treatment of UC needs to be investigated.MethodsIn this study, the therapeutic mechanism of YHKJ combined with SASP in the treatment of UC was predicted by network pharmacology and molecular docking. The chemical components and related targets of YHKJ were obtained from the TCMSP database. The chemical structure of SASP was obtained from the PubChem server, and related targets of SASP molecules were identified using the PharmMapper database. UC-related targets were obtained from the DisGeNET, GeneCards, OMIM, TTD, DrugBank and PharmGkb databases.ResultsIn total, 197 shared targets were identified by constructing a Venn diagram. PPI network data obtained from the STRING database were imported into Cytoscape to visualize the “drug-disease” target network, and STAT3 was selected as the core target by topological analysis. Gene Ontology revealed the biological functions of target genes, and KEGG analysis revealed that the core target STAT3 was differentially expressed in Th17 cells and the JAK-STAT signaling pathway. Thus, the core target STAT3 was subjected to molecular docking with the top 10 components, including nine YHKJ components (quercetin, luteolin, ursolic acid, daidzein, kaempferol, wogonin, myricetin, formononetin, indirubin) and SASP (C18H14N4O5S). The molecular docking results showed that STAT3 had favorable binding with the nine YHKJ components and SASP; STAT3 had the strongest binding with ursolic acid (−10.26 kcal/mol), followed by SASP (−8.54 kcal/mol). Qualitative analysis of the chemical constituents of YHKJ by HPLC revealed that sitosterol, ursolic acid, myricetin, daidzein, quercetin, kaempferol and formononetin were the main components. Additional experiments verified that YHKJ combined with SASP inhibited activation of the IL-6/JAK2/STAT3 pathway and alleviated inflammation in UC model rats.DiscussionOur results showed that seven chemical components in YHKJ cooperate with SASP to interfere with activation of the IL-6/JAK2/STAT3 pathway, thus playing a role in the treatment of UC.
A study on the mediating-moderate effect of the types of illicit drugs on mental health in China
Authors: Zhou Bo , Tan Jintao , Li Wenli , Yu Cheng 
Published: September 2024

BackgroundIn China, over 5 million people have been identified and registered by the public security institutions for using illicit drugs. The aim of this study is to compare the influence of different types of illicit drugs on the self-reported mental health of Chinese people. In particular, we want to assess the damage of Heroin, Methamphetamine and Ketamine to mental health in a social environment where drug use is strictly regulated.MethodsThe study is based on survey with 6,906 people who use drugs in Guangdong province, China. Risk of mental health issue is measured using the Brief Symptoms Inventory 18 (BSI-18) Scale, and a higher BSI-18 score indicates more severe mental health problems. The data was analyzed through multilevel regression analysis, propensity score matching analysis and mediation analysis.ResultsThe three major types of illicit drugs have both moderating and mediating effects on the length of drug-use history, that Heroin use leads to longer drug-use duration, while Ketamine use causes more damage on mental health per unit time of drug-use duration. Average duration of Methamphetamine use is 0.7 year shorter than average duration of Heroin use, and average duration of Ketamine use is 1.7 year shorter than average duration of Heroin use. For each year of increase of drug-use duration, Ketamine use leads to 1.2 times more of BSI score increase than Heroin use, and 2.3 times more of BSI score increase than Methamphetamine use.ConclusionThese three drugs are associated with severe mental health issue in a society with strict drug regulation. Attention should be paid to the mental health of people regardless of the type of drugs they use.
Impact of storm drains on the maintenance of dengue endemicity in Presidente Prudente, São Paulo, Brazil: a geospatial and epidemiologic approach
Authors: Bertacco Elaine Aparecida Maldonado , Prestes-Carneiro Luiz Euribel , de Araújo Renata Ribeiro , D'Andrea Lourdes Aparecida Zampieri , Pinheiro Luiza Sant'Anna , Flores Edilson Ferreira 
Published: September 2024

IntroductionDengue is a public health challenge worldwide. Brazil registered about 70% of cases in Latin America in 2023; in 2024, the country is experiencing an unprecedented increase in the number of infected individuals. By May 2024, more than 4 million people were infected. Our goal was to: (1) determine the epidemiology of dengue cases and their spatiotemporal distribution and (2) carry out a survey of the storm drains and through a geospatial analysis to determine their possible correlation with cases of dengue in Presidente Prudente, São Paulo, Brazil.MethodsCases and information on the habitat of mosquito in the storm drain underground drainage system from 2020 to 2021 were obtained from public agencies. Larvae, pupae, and Ae. aegypti were identified according to species and described in taxonomic keys. Kernel density maps were constructed.ResultsFrom 1996 to 2023, the prevalence of cases peaked in 2016 and 2019, and in 2023 reached alarming levels, and the city was considered hyperendemic. In 2021, 2,609 cases were registered with 2 clusters of high density. Of 5,492 storm drains analyzed, 18.0% were found to have water, 9.0% had larvae or pupae of Aedes aegypti and 91.0% were classified as dirty or damaged. A direct correlation between the kernel layer of cases in 2021 with the kernel layer of storm drains containing water (r = 0.651) and larvae and pupae (r = 0.576) was found, suggesting that storm drains are risk factors and have an impact on the maintenance of dengue endemicity. The high number of damaged units found demonstrated the lack of storm drain management, compromising the urban drainage system and possibly contributing to dengue outbreaks.ConclusionPolicymakers may use these findings to improve existing dengue control strategies focusing on the control of storm drains and increase local and global perspectives on reducing dengue outbreaks.
Mixed-Flow Turbofan Engine Model for the Conceptual Design of Sustainable Supersonic Airplanes
Authors: Piccirillo Grazia , Gregorio Antonio , Fusaro Roberta , Ferretto Davide , Viola Nicole 
Published: September 2024

Current research efforts on commercial supersonic flight aim to overcome past challenges by designing a new generation of sustainable supersonic airplanes. Achieving this goal requires careful consideration of the propulsion system during the design process. This study proposes a mixed-flow turbofan engine model coupled with emission estimation routines to increase the reliability of the conceptual design of future supersonic aircraft. The model enables parametric analyses by analyzing variations in main engine design parameters (πc,πf, BPR) as function of the system and mission requirements, such as the Mach number, and suggesting applicability boundaries. The overall methodology was applied to a low-boom Mach 1.5 case study, allowing for both on-design and off-design analyses and generating a propulsive database to support preliminary mission simulations and chemical emission estimation. Finally, the accuracy and reliability of the engine model was validated against GSP 11 data for a generic mixed-flow turbofan engine. A modified version of the Fuel Flow Method, originally developed by Boeing, allows for emissions estimation throughout the mission for a supersonic engine using biofuels. The application of the methodology led to the definition of an engine with a πc of 30 and BPR of 0.7 for the selected case study, which was successful in meeting the initial mission requirements.
Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model
Authors: Jornada Daniela Hartmann , Boreski Diogo , Chiba Diego Eidy , Ligeiro Denise , Luz Marcus Alexandre Mendes , Gabriel Edmo Atique , Scarim Cauê Benito , de Andrade Cleverton Roberto , Chin Chung Man 
Published: September 2024

Colorectal cancer (CRC) is one of the top 10 most common cancers worldwide and caused approximately 10 million deaths in 2022. CRC mortality has increased by 10% since 2020 and 52.000 deaths will occur in 2024, highlighting the limitations of current treatments due to ineffectiveness, toxicity, or non-adherence. The widely used chemotherapeutic agent, 5-fluorouracil (5-FU), is associated with several adverse effects, including renal, cardiac, and hepatic toxicity; mucositis; and resistance. Taurine (TAU), an essential β-amino acid with potent antioxidant, antimutagenic, and anti-inflammatory properties, has demonstrated protective effects against tissue toxicity from chemotherapeutic agents like doxorubicin and cisplatin. Taurine deficiency is linked to aging and cancers such as breast and colon cancer. This study hypothesized that TAU may mitigate the adverse effects of 5-fluorouracil (5-FU). Carcinogenesis was chemically induced in rats using 1,2-dimethylhydrazine (DMH). Following five months of cancer progression, taurine (100 mg/kg) was administered orally for 8 days, and colon tissues were analyzed. The results showed 80% of adenocarcinoma (AC) in DMH-induced control animals. Notably, the efficacy of 5-FU showed 70% AC and TAU 50% while, in the 5-FU + TAU group, no adenocarcinoma was observed. No differences were observed in the inflammatory infiltrate or the expression of genes such as K-ras, p53, and Ki-67 among the cancer-induced groups whereas APC/β-catenin expression was increased in the 5FU + TAU-treated group. The mitotic index and dysplasia were increased in the induced 5-FU group and when associated with TAU, the levels returned to normal. These data suggest that 5-FU exhibits a synergic anticancer effect when combined with taurine.
A Study on Usage of Formal Knowledge Sharing Systems in Project-Based Organizations
Authors: Ekambaram Anandasivakumar 
Published: September 2024

Projects are one-time activities that have time and resource limitations. Projects are considered as arenas for learning. There are opportunities for creating new knowledge and utilizing existing knowledge in projects. Since projects are per definition unique, there is at least some degree of uniqueness associated with each project. This uniqueness provides opportunities to learn something new in each project. The known element in projects – such as existing solutions that have been proven to produce good results – can be shared and utilized to avoid using time and resources to create the same or similar solutions from scratch. Knowledge sharing and learning can play a notable role in improving the ability of project-based organizations to carry out their projects successfully and contributing to obtain higher productivity, profitability and sustainable competitive advantage. However, there are several challenges. This paper looks at one of the challenges, namely ineffective usage of formal knowledge sharing systems in project-based organizations. In this regard, the following two research questions are considered: (1) What are the challenges of using formal knowledge sharing systems? (2) How can the challenges be addressed? Formal knowledge sharing systems play an important role in supporting knowledge sharing and learning in organizations. Technological development has created many possibilities to enhance functions as well as benefits of such systems. However, there are several factors that are to be taken into consideration in order to make sure an effective usage of formal knowledge sharing systems in project-based organizations. This paper presents six factors in this regard and emphasizes the need to have a strategic view and a top management perspective of knowledge sharing and learning in project-based organizations. The study on which this paper is based, is of qualitative nature. In this regard, interviews have been conducted to gather information from five public project-based organizations in Norway.
Pengaruh Pelayan dan Etika Bisnis Terhadap Loyalitas Nasabah di BMT UGT Nusantara Capem Labang
Authors: Umamah Umamah , Hasan Musohihul 
Published: September 2024

Lembaga keuangan adalah lembaga yang memiliki aturan atau perjanjian berdasarkan yang dilakukan pihak pertama dan pihak kedua, sedangkan lembaga keuangan itu ada dua, ada lembaga keuangan bank dan lembaga keuangan non bank. Lembaga keuangan non bank seperti asuransi, pengadaian dan koperasi simpan pinjam dan berbicara koperasi simpan pinjam saya tertarik dengan BMT Ugt Nusantara Capem 285 Labang yang pernah kami singgahi sehingga kami peneliti tertarik meneliti di koperasi itu untuk mengetahui pengaruh pelayanan dan etika bisnis terhadap loyalitas nasabah. Teknik pengambilan datanya menggunakan angket atau kuesioner dengan jumlah populasi 5 dan itu di jadikan sampel semua. Dan itu hasil penyebaran di uji dengan melalui aplikasi SPSS V 16.0. Hasil analisis regresi berganda mengasilkan pengaruh signifikan bahwa variabel X1 dan Variabel X2 berpengaruh terhadap Variabel Y seebesar 95 Persen dan 5 persen di pengaruhi oleh variabel lain sehingga kami penliti menyarankan untuk meningkatkan pelayanan dan etika bisnis agar loyalitas nasabah di Bmt Ugt Nuantara Capem 285 Labang semakin meningkat
Pengaruh Kualitas Produk Terhadap Omzet Penjualan di Warung Seroja Burneh Bangkalan
Authors: Wardillah Husti , Mudarris Mudarris 
Published: September 2024

Omzet penjualan menjadi prioritas utama dalam penelitian ini karena tingkat persaingan yang semakin tajam diantara bisnis kuliner yang ada di bangkalan saat ini. Perusahaan harus memperhatikan hal-hal yang dianggap penting guna mempertahankan konsumen, agar konsumen merasa puas dan terus berlangganan. maka dari itu penelitian ini bertujuan untuk mengetahui pengaruh kualitas roduk terhada omzet penjualan di Warung Seroja Burneh Bangkalan. Jenis penelitian ini menggunakan pendekatan kuantitatif dengan regresi linier sederhana dalam jumlah sampel sebanyak 36 responden dan menggunaka skala likert dengan pengambilan sampel yaitu menggunakan teknik sampel accidental sampling. Berdasarkan hasil penelitian pembahasan menunjukkan bahwa variabel bebab mempunyai pengaruh yang signifikan terhadap variabel terikat. Hal ini dapat dilihat dari hasil uji t hitung 8,836 lebih besar dari t tabel 1.69092
Origin of perpendicular magnetic anisotropy in Fe0.6Al0.4/Cr0.8Al0.2 metallic superlattice
Authors: Toyoki Kentaro , Minami Takehiro , Shiratsuchi Yu , Nakatani Ryoichi 
Published: September 2024

Abstract
In this study, we investigated a perpendicular magnetic anisotropy (PMA) in a ferromagnet/antiferromagnetic stacking structure without using heavy metal elements. The Fe0.6Al0.4/Cr0.8Al0.2/Fe0.6Al0.4 stacked films exhibited perpendicular magnetization. We discussed the origin of the PMA based on the Cr0.8Al0.2 thickness, t
Cr–Al (=0.6–3.0 nm) dependences of the uniaxial anisotropy energy density K
u, elastic strain ε
1 – ε
3, and unit cell volume V of the Fe0.6Al0.4 and Cr0.8Al0.2 layers. The K
u value was approximately 25 kJ m−3, independent of t
Cr–Al. The positive ε
1 – ε
3, i.e., the tensile strain in the Cr0.8Al0.2 layer can promote the PMA. The possible degradation of PMA due to the lattice relaxation with increasing t
Cr–Al could be compensated by recovering the Cr magnetic moment. Our analysis suggests that PMA is caused by interfacial exchange coupling between ferromagnetic Fe0.6Al0.4 and antiferromagnetic Cr0.8Al0.2.
Effects of Repeatability and Heritability Growth Traits on Indigenous Guinea Pigs in Nigeria
Authors: Afodu Osagie 
Published: September 2024

This study focused on the genetic parameter (heritability and repeatability) estimates of growth traits of indigenous guinea pig in Nigeria. The repeatability and heritability estimates of live body weight at birth, pre, and post weaning phases of indigenous guinea pig was measured.
A total of 197 indigenous growing guinea pigs, progeny of 6 sires and 18 dams was selected and raised at the Babcock University Animal holding facilities, Ilishan Remo. They were individually housed in separate labelled plastic cages. Data collected for birth weight, pre, and post weaning weight were used to evaluate the descriptive statistic, repeatability and heritability estimate using Restricted maximum likelihood (REML) of SAS software. The mean values of the live body weight revealed a consistent increase from 76.510g (birth weight) and 83.728 – 241.679 g pre-weaning (week 1-7) weight and 265.600 – 330.884 post-weaning (week 8 – 13) weight in female while the male growing guinea pig had 76.510 g (birth weight to 83.677 – 241.679 g (pre-weaning (week 1-7) weight and 265.600 – 330.986 post-weaning (week 8 – 13) weight.
Birth weight recorded a high estimate of repeatability for growing female guinea pig whereas, the anchored week, 4th week of age for pre-weaning phase and 13th week of age for post-weaning phase were lowly repeatable for female and heritable for male; indicating that additional records would be required to adequately characterize the inherent production ability of live body weight for dam and sire at pre and post weaning phases as breeding age progressed.
It is therefore concluded that the low repeatability and heritability estimates recorded showed that collection of additional records and improvement of non-genetic factors influencing the growth traits would improve the accuracy of data for repeatability and heritability of growth trait of indigenous guinea pigs in Nigeria.
Ciências sociais e Ciências Naturais na formação em Nutrição: discutindo a opinião de estudantes no Brasil e na Espanha
Authors: Fonseca Alexandre Brasil , Frozi Daniela Sanches 
Published: September 2024

Nosso interesse neste estudo está em considerar as diferenças nos cursos de Nutrição do Brasil e da Espanha. Ele faz parte de um estudo comparativo, com o objetivo principal de discutir o papel das ciências sociais na formação em Nutrição nestes dois países. A questão analisada considera a importância relativa dada pelos estudantes de nutrição durante toda a sua graduação. Métodos. Foram utilizados métodos quantitativos e qualitativos. Foram aplicados questionários entre 820 estudantes de 17 universidades no Rio de Janeiro (Brasil) e na Catalunha (Espanha), enquanto grupos focais e entrevistas foram realizadas em ambos os países envolvendo alunos de cada ano do curso realizado. Os resultados do questionário foram analisados ​​utilizando a escala de Likert, com as respostas divididos de acordo com as frequências relativas ponderadas. Resultados. Os estudantes brasileiros consideraram mais importante a disciplina de química ao longo de sua formação (p <0,05), enquanto os estudantes de espanhol, enfatizaram a importância das disciplinas sociais, como sociologia e psicologia (p <0,05) em oposição à química e a estatística. Conclusão. Estes resultados fornecem um aparente paradoxo, pois diante das maiores desigualdades socioeconômicas existentes no contexto brasileiro, as questões sociais poderiam ter maior pertinência para o exercício profissional das futuras nutricionistas. Os resultados deste estudo abrem possibilidades para uma maior contextualização nas abordagens dadas às ciências naturais, incluindo o necessário diálogo com questões relacionadas à sociedade e à cultura, bem como a possibilidade de ampliar o foco do ensino sobre o corpo humano ao articular aspectos sociais, econômicos e políticos.
EXAMINATION OF RIVER INFRASTRUCTURE CONSTRUCTION PROJECTS
Authors: Прокопенко Анастасия Александровна 
Published: September 2024

Речная инфраструктура играет важную роль в обеспечении устойчивого развития региона и страны в целом. В статье рассматривается процесс экспертизы проектов строительства речной инфраструктуры в России. Статья подчеркивает необходимость комплексного подхода для устойчивого и эффективного развития речной инфраструктуры.
River infrastructure plays an important role in ensuring the sustainable development of the region and the country as a whole. The article discusses the process of examination of river infrastructure construction projects in Russia. The article emphasizes the need for an integrated approach for sustainable and efficient development of river infrastructure.
METHODS FOR DETERMINING THE EFFECTIVENESS OF ACCESSORY COMMUNICATION
Authors: Трухан Роман Петрович 
Published: September 2024

В работе рассказывается о проблемах установления методов определения эффективности акцессорной связи, как правового средства. Сделан вывод о сложности такого исследования ввиду смешения категорий «результативность» и «эффективность» акцессорной связи, недостаточности эмпирического материала, имеющего количественные оценки, а также отсутствие комплексного подхода в использовании методов и методик.
The work describes the problems of establishing methods for determining the effectiveness of accessory communication as a legal means. A conclusion is made about the complexity of such research due to the confusion of the categories “effectiveness” and “efficiency” of accessory communication, the lack of empirical material with quantitative estimates, as well as the lack of an integrated approach to the use of methods and techniques.