bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gray matter trophism, cognitive impairment, and depression in patients with multiple sclerosis
Authors: Pravatà Emanuele , Rocca Maria A , Valsasina Paola , Riccitelli Gianna C , Gobbi Claudio , Comi Giancarlo , Falini Andrea , Filippi Massimo 
Published: February 2017

Background: Cognitive impairment and depression frequently affects patients with multiple sclerosis (MS). However, the relationship between the occurrence of depression and cognitive impairment and the development of cortical atrophy has not been fully elucidated yet. Objectives: To investigate the association of cortical and deep gray matter (GM) volume with depression and cognitive impairment in MS. Methods: Three-dimensional (3D) T1-weighted scans were obtained from 126 MS patients and 59 matched healthy controls. Cognitive impairment was assessed using the Brief Repeatable Battery of Neuropsychological Tests and depression with the Montgomery-Asberg Depression Rating Scale (MADRS). Using FreeSurfer and FIRST software, we assessed cortical thickness (CTh) and deep GM volumetry. Magnetic resonance imaging (MRI) variables explaining depression and cognitive impairment were investigated using factorial and classification analysis. Multivariate regression models correlated GM abnormalities with symptoms severity. Results: Compared with controls, MS patients exhibited widespread bilateral cortical thinning involving all brain lobes. Depressed MS showed selective CTh decrease in fronto-temporal regions, whereas cognitive impairment MS exhibited widespread fronto-parietal cortical and subcortical GM atrophy. Frontal cortical thinning was the best predictor of depression ( C-statistic = 0.7), whereas thinning of the right precuneus and high T2 lesion volume best predicted cognitive impairment ( C-statistic = 0.8). MADRS severity correlated with right entorhinal cortex thinning, whereas cognitive impairment severity correlated with left entorhinal and thalamus atrophy. Conclusion: MS-related depression is linked to circumscribed CTh changes in areas deputed to emotional behavior, whereas cognitive impairment is correlated with cortical and subcortical GM atrophy of circuits involved in cognition.
Reproducibility of a Noninvasive System for Eye Positioning and Monitoring in Stereotactic Radiotherapy of Ocular Melanoma
Authors: Iskanderani Omar , Béliveau-Nadeau Dominique , Doucet Robert , Coulombe Geneviève , Pascale Deborah , Roberge David 
Published: February 2017

Purpose: Our preferred treatment for juxtapapillary choroidal melanoma is stereotactic radiotherapy. We aim to describe our immobilization system and quantify its reproducibility. Materials and Methods: Patients were identified in our radiosurgery database. Patients were imaged at computed tomography simulator with an in-house system which allows visual monitoring of the eye as the patient fixates a small target. All patients were reimaged at least once prior to and/or during radiotherapy. The patients were treated on the CyberKnife system, 60 Gy in 10 daily fractions, using skull tracking in conjunction with our visual monitoring system. In order to quantify the reproducibility of the eye immobilization system, computed tomography scans were coregistered using rigid 6-dimensional skull registration. Using the coregistered scans, x, y, and z displacements of the lens/optic nerve insertion were measured. From these displacements, 3-dimensional vectors were calculated. Results: Thirty-four patients were treated from October 2010 to September 2015. Thirty-nine coregistrations were performed using 73 scans (2-3 scans per patient). The mean displacements of lens and optic nerve insertion were 0.1 and 0.0 mm. The median 3-dimensional displacements (absolute value) of lens and nerve insertion were 0.8 and 0.7 mm (standard deviation: 0.5 and 0.6 mm). Ninety-eight percent of 3-dimensional displacements were below 2 mm (maximum 2.4 mm). The calculated planning target volume (PTV) margins were 0.8, 1.4, and 1.5 mm in the anterior–posterior, craniocaudal, and right–left axes, respectively. Following this analysis, no further changes have been applied to our planning margin of 2 to 2.5 mm as it is also meant to account for uncertainties in magnetic resonance imaging to computed tomography registration, skull tracking, and also contouring variability. Conclusion: We have found our stereotactic eye immobilization system to be highly reproducible (<1 mm) and free of systematic error.
Building trust and diversity in patient-centered oncology clinical trials: An integrated model
Authors: Hurd Thelma C , Kaplan Charles D , Cook Elise D , Chilton Janice A , Lytton Jay S , Hawk Ernest T , Jones Lovell A 
Published: February 2017

Background/aims: Trust is the cornerstone of clinical trial recruitment and retention. Efforts to decrease barriers and increase clinical trial participation among diverse populations have yielded modest results. There is an urgent need to better understand the complex interactions between trust and clinical trial participation. The process of trust-building has been a focus of intense research in the business community. Yet, little has been published about trust in oncology clinical trials or the process of building trust in clinical trials. Both clinical trials and business share common dimensions. Business strategies for building trust may be transferable to the clinical trial setting. This study was conducted to understand and utilize contemporary thinking about building trust to develop an Integrated Model of Trust that incorporates both clinical and business perspectives. Methods: A key word–directed literature search of the PubMed, Medline, Cochrane, and Google Search databases for entries dated between 1 January 1985 and 1 September 2015 was conducted to obtain information from which to develop an Integrated Model of Trust. Results: Successful trial participation requires both participants and clinical trial team members to build distinctly different types of interpersonal trust to effect recruitment and retention. They are built under conditions of significant emotional stress and time constraints among people who do not know each other and have never worked together before. Swift Trust and Traditional Trust are sequentially built during the clinical trial process. Swift trust operates during the recruitment and very early active treatment phases of the clinical trial process. Traditional trust is built over time and operates during the active treatment and surveillance stages of clinical trials. The Psychological Contract frames the participants’ and clinical trial team members’ interpersonal trust relationship. The “terms” of interpersonal trust are negotiated through the psychological contract. Contract renegotiation occurs in response to cyclical changes within the trust relationship throughout trial participation. Conclusion: The Integrated Model of Trust offers a novel framework to interrogate the process by which diverse populations and clinical trial teams build trust. To our knowledge, this is the first model of trust-building in clinical trials that frames trust development through integrated clinical and business perspectives. By focusing on the process, rather than outcomes of trust-building diverse trial participants, clinical trials teams, participants, and cancer centers may be able to better understand, measure, and manage their trust relationships in real time. Ultimately, this may foster increased recruitment and retention of diverse populations to clinical trials.
Results of 115 Rubis II reverse thumb carpometacarpal joint prostheses with a mean follow-up of 10 years
Authors: Dehl M. , Chelli M. , Lippmann S. , Benaissa S. , Rotari V. , Moughabghab M. 
Published: February 2017

The aim of this study was to assess the clinical and radiological results of the Rubis II thumb carpometacarpal joint reverse prosthesis, at a mean follow-up of 10 years. Between 1997 and 2008, 253 prostheses were implanted in 199 patients; 115 were reviewed. The survival after a mean of 10 years was 89%. At the last follow-up, 70% of prostheses were painless; the others reported moderate or intermittent pain. The satisfaction rate was 98%. The mean opposition was 9 on the Kapandji scale; the mean QuickDASH score was 30. Wrist, key and tip pinch strengths were comparable with the non-operated side. Of the 115 implants, one was radiologically loose (1%) and 15 had suffered dislocations (13%), 12 of which were caused by an injury. Eleven thumbs had revision surgery. This study confirms that the good clinical results of the Rubis II prosthesis are maintained in the medium and long term, and represents a useful alternative to trapeziectomy for selected patients. Level of evidence: IV
Moisturisers for the treatment of foot xerosis: a systematic review
Authors: Parker Justin , Scharfbillig Rolf , Jones Sara 
Published: February 2017

AbstractBackgroundXerosis, literally dryness of the skin, of the foot is a common condition encountered clinically, which can lead to discomfort and predisposition to infection. Currently, there are no evidence‐based recommendations on which moisturiser formulations best alleviate xerotic symptoms. The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis, by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population.MethodsA systematic review of published experimental trials was undertaken. Only studies pertaining to primary xerosis, classified within levels II – IV of the NHRMC hierarchy were reviewed. EMBASE, AMED, Cochrane, MEDLINE, CINAHL, Ageline and SCOPUS were searched using relevant search terms and keywords and pearling of reference lists was undertaken. Studies were evaluated for methodological quality using a critical appraisal tool. Individual active ingredients were identified from all studies, along with observed reported outcomes. A narrative synthesis was then conducted.ResultsA total of 22 experimental studies were included, from which 12 different active ingredients were identified. Study literature consisted of mainly comparative studies against other active interventions or controls, or pre‐post‐tests and was of a poor‐to‐moderate methodological quality as assessed by the Epidemiological Appraisal Instrument. Urea was the most researched active ingredient (14 studies), with ammonium lactate being next (7 studies).ConclusionsNo conclusive recommendations were possible due to wide variation in study quality, methodologies and outcome measures. A synthesis of available literature suggests that treatments containing urea as a primary active ingredient have been the most researched. The poor quality of literature generally, however, precludes recommendation of any active ingredient over another.
The Aurora-A–Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
Authors: Wang Jing , Nikhil Kumar , Viccaro Keith , Chang Lei , Jacobsen Max , Sandusky George , Shah Kavita 
Published: February 2017

ABSTRACT
We uncovered a crucial role for the Aurora kinase A (AURKA)–Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT-specific target of AURKA that was identified using an innovative screen. AURKA phosphorylates Twist1 at three sites, which results in its multifaceted regulation – AURKA inhibits its ubiquitylation, increases its transcriptional activity and favors its homodimerization. Twist1 reciprocates and prevents AURKA degradation, thereby triggering a feedback loop. Ablation of either AURKA or Twist1 completely inhibits EMT, highlighting both proteins as central players in EMT progression. Phosphorylation-dead Twist1 serves as a dominant-negative and fully reverses the EMT phenotype induced by Twist1, underscoring the crucial role of AURKA-mediated phosphorylation in mediating Twist1-induced malignancy. Likewise, Twist1-overexpressing BxPC3 cells formed large tumors in vivo, whereas expression of phosphorylation-dead Twist1 fully abrogated this effect. Furthermore, immunohistochemical analysis of pancreatic cancer specimens revealed a 3-fold higher level of Twist1 compared to that seen in healthy normal tissues. This is the first study that links Twist1 in a feedback loop with its activating kinase, which indicates that concurrent inhibition of AURKA and Twist1 will be synergistic in inhibiting pancreatic tumorigenesis and metastasis.
Personal and Family Sources of Parents’ Socialization Values: A Multilevel Study
Authors: Barni Daniela , Ranieri Sonia , Donato Silvia , Tagliabue Semira , Scabini Eugenia 
Published: February 2017

Este estudio se centró en los valores de socialización de los padres, es decir los valores que los padres quieren que sus hijos adopten, y sus fuentes. En una muestra de 325 familias italianas con un hijo adolescente (14-18 años), se compararon los valores de socialización entre los padres y las madres, y se evaluaron los valores personales de los padres y el clima de valores familiares como antecedentes de los valores que los padres quisieran que sus hijos adquirieran. Para cada familia se tuvieron en cuenta a ambos padres y al adolescente, y se les pidió que completaran individualmente el Portrait Values Questionnaire. Los resultados de la Anova han revelado una diferencia significativa entre los valores de socialización de los padres y los de las madres: los padres consideran más importantes que las madres los valores de apertura al cambio y los del autocrecimiento en la educación de sus hijos. Utilizando un análisis multinivel, al incluirse tanto padres como madres dentro del contexto familiar, hemos encontrado relaciones significativas entre todos los valores personales de los padres y sus valores de socialización, por un lado, y entre el clima de valores familiares y algunos de los valores de socialización de los padres, por el otro. Contrariamente, la interacción entre los valores personales de los padres y el clima de valores familiares no contribuye en predecir los valores que los padres quieren que sus hijos adopten. Se discuten las implicaciones de esta investigación y sus posibles desarrollos
Intrauterine device uptake among women seeking family planning services in Nairobi County, Kenya
Authors: Mbuthia Florence W. , Okumbe Gaundencia M. , Monda Jonathan , Ng'ang'a Paul M. 
Published: February 2017

Aims: The main objective of this study was to determine the uptake of the intrauterine device (IUD) among women seeking family planning (FP) services at Level 4 public hospitals in Nairobi County. Methods: This was a descriptive, cross-sectional study that used both quantitative and qualitative approaches. Interviewer-administered, semi-structured questionnaires, focus group discussions and key informant interviews were used to collect data. Sample size was 380 women with 100% response rate. Findings: The uptake of IUD was 7.9% (95% confidence interval (CI): 2.6–13.2%). The uptake increased with age, with those aged above 30 years using the device more compared with those aged below 30 years. Drivers of IUD uptake included: parity (adjusted odds ratio (aOR)=8.545 CI: 4.399–16.599%,P<0.001), awareness of IUD provision in the facility (aOR=1.824, P=0.038) and a favourable perception of IUD (aOR=5.816, P<0.001). The qualitative data from the focus group discussion included common myths such as: ‘IUD might travel to other body organs’ and ‘it spreads infection in the body’. Conclusion: Uptake is low in the two hospitals and more awareness should be created on IUD availability. Uptake should be encouraged among young women and those of lower parity.
The Assessment of Patient Satisfaction and Attendance of Community Pharmacies in Slovakia
Authors: Mináriková D. , Malovecká I. , Lehocká Ľ. , Snopková M. , Foltán V. 
Published: February 2017

Abstract
Aim: Patient-oriented pharmaceutical care in pharmacies could improve patient satisfaction and influence patient’s choice of a community pharmacy. The aim of the work was to assess patient satisfaction and attendance in community pharmacies in Slovakia. Methods: A self-administered, anonymous questionnaire was distributed to patients visiting 33 community pharmacies in a total of 23 Slovak cities during October-December 2013. The questionnaire contained 29 items and three dimensions were supposed (managing therapy, interpersonal relationship, general satisfaction). A 5-point Likert-type scale (1 = very satisfied, 2 = satisfied, 3 = neither satisfied nor dissatisfied, 4 = dissatisfied, 5 = very dissatisfied) was used for assessing patient satisfaction. The results are presented in percentages and by the level of satisfaction within the range: high satisfaction (score 1.00-2.50), moderate satisfaction (score 2.51-3.50) and low satisfaction (score 3.51-5.00). Reasons for attendance in the community pharmacy and factors influencing pharmacy choice were evaluated either. Results: A total 2 844 respondents were included into the survey. Patient satisfaction with pharmaceutical care achieved high satisfaction level: interpersonal relationship (1.85 ± 0.598; 86.7% highly satisfied respondents) and general satisfaction (2.02 ± 0.643; 71.3% highly satisfied respondents). Managing therapy scored lower (2.24 ± 0.704; 65.4% highly satisfied respondents). The most frequently reported reasons for attending community pharmacy were to obtain prescription (70.4%) and over-the-counter medications (70.4%). The patient choice of a particular pharmacy was influenced by its location (74.1%). Conclusion: This study presents the first nationwide patientreported outcomes about patient satisfaction and attendance in community pharmacies in Slovakia. Future development and advancement of pharmacy practice leading to higher patient satisfaction requires modification of community pharmacists’ professional behaviour in Slovakia namely in managing therapy of patients.
Antibody Microarray Expression Profiling Of Maize Roots Treated With Cadmium And Nickel
Authors: Repka Vladimír , Fiala Roderik , Čiamporová Milada , Martinka Michal , Pavlovkin Ján 
Published: February 2017

Abstract
Here, we report the effectiveness of antibody microarray expression profiling (AbMEP) procedure to determine similarities and differences between two maize cultivars (Premia and Blitz) exposed to various concentration of cadmium (Cd), nickel (Ni), as well as simultaneous exposure to both metals (Cd + Ni) for 0, 12 and 24 h. After protein extraction from control (untreated) and heavy metals (HM)-treated root pairs and their fluorescent labelling, the protein extracts were used for the AbMEP procedure and western blot analysis. The results from the microarray were analysed using an internally normalised ratio. Using this highly parallel AbMEP-approach, the timing, dynamics and regulation of the expression of 101 specific genes in untreated and HM-treated roots of maize cultivars were determined. The microarray results revealed 23, 15 and 10 up-regulated/down-regulated proteins in Cd, Ni and Cd + Ni treated cv. Premia roots, respectively. In contrast, the microarray results revealed that 15, 11 and 7 proteins were up-regulated/down-regulated in Cd, Ni and Cd + Ni treated cv. Blitz roots, respectively. The data obtained from the AbMEP array experiment were validated by western blot analyses with more than 89% (the Pearson’s correlation coeficient Rr = 0.78) correlation between the two methods.
Ornements transfrontières/avant-gardes marocaines : entre ésotérisme et post-colonialisme
Authors: Montazami Morad 
Published: February 2017

Abstract
The discourses surrounding the ornament in Western modernist and formalist art theory (Riegl, Focillon) encourage such ideas as the emancipation of the ornament. The same preoccupation has been followed – from a totally different perspective – by Moroccan avant-garde painters (Ahmed Cherkaoui, Farid Belkahia and the Casablanca School) who stood up for the decolonization of arts and culture. How can we retrace the visual and literary genealogy (in practice and theory) that led to this esoteric use of the ornament as a tool for mobility and migration through strategies of sign making and identity politics?
Bayesian environment representation, prediction, and criticality assessment for driver assistance systems
Authors: Schreier Matthias 
Published: February 2017

Abstract
The dissertation approaches the questions i) how to represent the driving environment in an environment model, ii) how to
obtain such a representation, and iii) how to predict the traffic scene for criticality assessment. Bayesian inference
provides the common framework of all designed methods. First, Parametric Free Space (PFS) maps are introduced, which
compactly represent the vehicle environment in form of relevant, drivable free space. They are obtained by a novel method
for grid mapping and tracking in dynamic environments. In addition, a maneuver-based, long-term trajectory prediction and
criticality assessment system is introduced and the application of all methods within the advanced driver assistance
system PRORETA 3 is described.
Physiological responses of Porphyra haitanensis (Rhodophyta) to copper and cadmium exposure
Authors: Zhu Xifeng , Zou Dinghui , Huang Yanhua , Cao Junming , Sun Yuping , Chen Bing , Chen Xiaoying 
Published: February 2017

Abstract
The aim of the present work was to evaluate the effects of copper (Cu) and cadmium (Cd) on the physiology of the red macroalga Porphyra haitanensis Chang and Zheng. The alga was cultured in media with different Cu or Cd concentrations for 7 days. The relative growth rate was significantly reduced at Cu concentrations of 0.10 mg l−1 and above or at Cd concentrations of 4 mg l−1 and above. Chlorophyll a (Chl a), carotenoids (Car), phycoerythrin (PE) and phycocyanin (PC) contents decreased at high Cu or Cd concentrations, and PE content increased at 0.10 mg l−1 Cu or 4–8 mg l−1 Cd. Moreover, the optimal quantum yield, maximum net photosynthetic rate (Pm) and apparent photosynthetic efficiency (α) were significantly reduced at high Cu or Cd concentrations. In contrast, malondialdehyde (MDA) content and superoxide dismutase (SOD) activity increased in response to Cu or Cd treatment. Catalase activity increased at 2–8 mg l−1 Cd and significantly declined at 0.50 mg l−1 Cu or 10 mg l−1 Cd. Nitrate reductase (NR) activity declined at high Cu or Cd concentrations. Consequently, both Cu and Cd were physiological stressors for P. haitanensis, with Cu being more toxic than Cd. This work has generated valuable knowledge about the toxic effects of Cu and Cd on macroalgae.
Bio-based polymer from heterogeneous catalytic polymerization of vegetable oils
Authors: Latifi Seyed Mahdi , Salehirad Alireza , Soltani Atefeh , Bakhshi Azghandi Javad 
Published: February 2017

AbstractRecently, printing ink ingredients have been provided from vegetable oils as a renewable, non-toxic, and biodegradable resource. In this work, to produce bio-based polymer potentially exploitable in printing ink vehicles, tris(ethylenediamine)nickel(II) nitrate and bis(ethylenediamine)copper(II) nitrate complexes were synthesized, characterized, and then used as heterogeneous catalysts for polymerization of soybean oil. Also, nickel and copper oxide catalysts were fabricated through thermolysis of the mentioned complexes and, after characterization, were employed for the polymerization reaction. The results showed that the presence of nickel and copper complex catalysts favored the reaction progress as the viscosity of the reaction product was increased 4 and 1.3 times, respectively, compared with polymerization without a catalyst. Also, the results obtained from using nickel and copper oxides indicated that these metal oxides do not have a significant effect on the reaction process.