bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple-factor analysis of the first radioactive iodine therapy in post-operative patients with differentiated thyroid cancer for achieving a disease-free status
Authors: Liu Na , Meng Zhaowei , Jia Qiang , Tan Jian , Zhang Guizhi , Zheng Wei , Wang Renfei , Li Xue , Hu Tianpeng , Upadhyaya Arun , Zhou Pingping , Wang Sen 
Published: October 2016

Abstract131I treatment is an important management method for patients with differentiated thyroid cancer (DTC). Unsuccessful 131I ablation drastically affects the prognosis of the patients. This study aimed to analyze potential predictive factors influencing the achievement of a disease-free status following the first 131I therapy. This retrospective review included 315 DTC patients, and multiple factors were analyzed. Tumor size, pathological tumor stage, lymph node (LN) metastasis, distant metastasis, American Thyroid Association recommended risks, pre-ablation thyroglobulin (Tg), and thyroid stimulating hormone (TSH) displayed significant differences between unsuccessful and successful group. Cutoff values of Tg and TSH to predict a successful outcome were 3.525 ng/mL and 99.700 uIU/ml by receiver operating characteristic curves analysis. Binary logistic regression analysis showed that tumor stage T3 or T4, LN metastasis to N1b station, intermediate and high risks, pre-ablation Tg ≥ 3.525 ng/ml and TSH <99.700 μIU/mL were significantly associated with unsuccessful outcomes. Logistic regression equation for achieving a disease-free status could be rendered as: y (successful treatment) = −0.270–0.503 X1 (LN metastasis) −0.236 X2 (Tg) + 0.015 X3 (TSH). This study demonstrated LN metastasis, pre-ablation Tg and TSH were the most powerful predictors for achieving a disease-free status by the first 131I therapy.
GFinisher: a new strategy to refine and finish bacterial genome assemblies
Authors: Guizelini Dieval , Raittz Roberto T. , Cruz Leonardo M. , Souza Emanuel M. , Steffens Maria B. R. , Pedrosa Fabio O. 
Published: October 2016

AbstractDespite the development in DNA sequencing technology, improving the number and the length of reads, the process of reconstruction of complete genome sequences, the so called genome assembly, is still complex. Only 13% of the prokaryotic genome sequencing projects have been completed. Draft genome sequences deposited in public databases are fragmented in contigs and may lack the full gene complement. The aim of the present work is to identify assembly errors and improve the assembly process of bacterial genomes. The biological patterns observed in genomic sequences and the application of a priori information can allow the identification of misassembled regions, and the reorganization and improvement of the overall de novo genome assembly. GFinisher starts generating a Fuzzy GC skew graphs for each contig in an assembly and follows breaking down the contigs in critical points in order to reassemble and close them using jFGap. This has been successfully applied to dataset from 96 genome assemblies, decreasing the number of contigs by up to 86%. GFinisher can easily optimize assemblies of prokaryotic draft genomes and can be used to improve the assembly programs based on nucleotide sequence patterns in the genome. The software and source code are available at http://gfinisher.sourceforge.net/.
Autonomously folded α-helical lockers promote RNAi*
Authors: Guyader Christian P. E. , Lamarre Baptiste , De Santis Emiliana , Noble James E. , Slater Nigel K. , Ryadnov Maxim G. 
Published: October 2016

AbstractRNAi is an indispensable research tool with a substantial therapeutic potential. However, the complete transition of the approach to an applied capability remains hampered due to poorly understood relationships between siRNA delivery and gene suppression. Here we propose that interfacial tertiary contacts between α-helices can regulate siRNA cytoplasmic delivery and RNAi. We introduce a rationale of helical amphipathic lockers that differentiates autonomously folded helices, which promote gene silencing, from helices folded with siRNA, which do not. Each of the helical designs can deliver siRNA into cells via energy-dependent endocytosis, while only autonomously folded helices with pre-locked hydrophobic interfaces were able to promote statistically appreciable gene silencing. We propose that it is the amphipathic locking of interfacing helices prior to binding to siRNA that enables RNAi. The rationale offers structurally balanced amphipathic scaffolds to advance the exploitation of functional RNAi.
MHDA-Functionalized Multiwall Carbon Nanotubes for detecting non-aromatic VOCs
Authors: Thamri Atef , Baccar Hamdi , Struzzi Claudia , Bittencourt Carla , Abdelghani Adnane , Llobet Eduard 
Published: October 2016

AbstractThe chemical modification of multiwalled carbon nanotubes (MWCNTs) with a long chain mercapto acid is reported as a way to improve sensitivity and response time of gas sensors for detecting alcohols, acetone and toxic gases such as DMMP. We have developed sensors employing MWCNTs decorated with gold nanoparticles and modified with a 16-mercaptohexadecanoic acid (MHDA) monolayer. Morphological and compositional analysis by Transmission Electron Microscopy (TEM), Fourier Transform Infra-red Spectroscopy (FTIR) and X-ray photoelectron spectroscopy were performed to characterize the gold nanoparticles and to check the bonding of the thiol monolayer. The detection of aromatic and non-aromatic volatiles and DMMP vapors by MWCNT/Au and MWCNT/Au/MHDA shows that the presence of the self-assembled layer increases sensitivity and selectivity towards non-aromatics. Furthermore, it ameliorates response dynamics, and significantly reduces nitrogen dioxide and moisture cross-sensitivity.
Driver circuit for a PAM‐4 optical transmitter using 65 nm CMOS and silicon photonic technologies
Authors: Zhou S. , Wu H. , Sadeghipour K. , Scarcella C. , Eason C. , Rensing M. , Power M. , Antony C. , O'Brien P. , Townsend P. , Ossieur P. 
Published: October 2016

A push–pull silicon photonic Mach–Zehnder modulator (MZM) driver is presented which uses a switched capacitor approach to generate a ∼2 V peak‐to‐peak differential 4‐level pulse amplitude modulation (PAM‐4) signal. The driver chip includes a Gray encoder and retiming flip‐flops. The switched capacitor approach allows driving the lumped silicon photonic MZM with reduced power consumption compared with the conventional approach of driving MZMs (with transmission line based electrodes) with a power amplifier. This is critical for upcoming short‐reach link standards such as 400 Gbit/s 802.3 Ethernet. The chip was fabricated using a 65 nm CMOS technology and flip‐chipped on top of the silicon photonic chip (fabricated using IMEC's ISIPP25G technology) that contains the MZM. Open eyes with 4 dB extinction ratio for a 36 Gbit/s (18 Gbaud) PAM‐4 signal are experimentally demonstrated. The electronic driver chip has a core area of 0.11 mm2 and consumes 236 mW from 1.2 to 2.4 V supply voltages. This corresponds to an energy efficiency of 6.55 pJ/bit including Gray encoder and retiming, or 5.37 pJ/bit for the driver circuit only.
Reach, engagement, and effectiveness: a systematic review of evaluation methodologies used in health promotion via social networking sites
Authors: Lim Megan S. C. , Wright Cassandra J. C. , Carrotte Elise R. , Pedrana Alisa E. 
Published: October 2016

Issue addressedSocial networking sites (SNS) are increasingly popular platforms for health promotion. Advancements in SNS health promotion require quality evidence; however, interventions are often not formally evaluated. This study aims to describe evaluation practices used in SNS health promotion.MethodsA systematic review was undertaken of Medline, PsycINFO, Scopus, EMBASE, CINAHL Plus, Communication and Mass Media Complete, and Cochrane Library databases. Articles published between 2006 and 2013 describing any health promotion intervention delivered using SNS were included.ResultsForty‐seven studies were included. There were two main evaluation approaches: closed designs (n = 23), which used traditional research designs and formal recruitment procedures; and open designs (n = 19), which evaluated the intervention in a real‐world setting, allowing unknown SNS users to interact with the content without enrolling in research. Closed designs were unable to assess reach and engagement beyond their research sample. Open designs often relied on weaker study designs with no use of objective outcome measures and yielded low response rates.ConclusionsBarriers to evaluation included low participation rates, high attrition, unknown representativeness and lack of comparison groups. Acceptability was typically assessed among those engaged with the intervention, with limited population data available to accurately assess intervention reach. Few studies were able to assess uptake of the intervention in a real‐life setting while simultaneously assessing effectiveness of interventions with research rigour.So what?Through use of quasi‐experimental or well designed before‐after evaluations, in combination with detailed engagement metrics, it is possible to balance assessment of effectiveness and reach to evaluate SNS health promotion.
A Proposal for a Next Generation European Neutron Source
Authors: Andersen K.H. , Carlile C.J. 
Published: October 2016

Abstract
We argue that it is not too early to begin the planning process for a next generation neutron source for Europe, even as the European Spallation Source is being constructed. We put forward three main arguments. Firstly, nowadays the period between the first scientific concept of a new facility being proposed and its actual realisation is approaching half a century. We show evidence for this. Secondly, there is a straightforward development of the short pulse/long pulse spallation concepts that will deliver gains in neutron brightness of more than a factor 30 over what the ESS will soon deliver and provide the optimum balance between resolution and intensity. We describe our concept, which is a spallation source where the proton pulse length is matched to the moderating time of slow neutrons. Thirdly, when we look at our colleagues in astronomy and high energy physics, we see that they have a totally different, more global and more ambitious approach to the coming generations of large facilities. We argue that it is time for the neutron community not simply to rest upon its laurels and take what is given but to be proactive..
No Place for the Political: Micro‐Geographies of the Paris Climate Conference 2015
Authors: Weisser Florian , Müller‐Mahn Detlef 
Published: October 2016

AbstractBuilding upon post‐foundational political philosophies, this article scrutinizes the Paris Climate Conference in December 2015 from a micro‐geographical perspective. The analysis suggests that three different spaces exist at the site of the summit and reveals how their constituting practices and material arrangements rendered “Paris” post‐democratic. We begin with exposing the staged statements of the world's political elites in the meticulously orchestrated Leaders Event as different phenotypes of the post‐democratic condition. We then investigate the formal negotiations in the cordoned‐off backrooms, where positions within the system were at stake, but not the system as such. Finally, we wander through the strictly policed “trade fair” and unveil attempts to entice delegates into techno‐managerial solutions to the climate crisis. In the conclusion, we ponder over the prospects of environmental activism at the COPs in the light of their massive depoliticization.
ОСОБЛИВОСТІ ПСИХОПАТОЛОГІЧНОЇ СИМПТОМАТИКИ У ЕМІГРАНТІВ ТА РЕЕМІГРАНТІВ, ХВОРИХ НА ДЕПРЕСИВНІ РОЗЛАДИ
Authors: Venher O. P. 
Published: October 2016

<p>РЕЗЮМЕ. Дослідження особливостей психопатологічної симптоматики за допомогою опитувальника Symptom Check List-90-Revised – SCL-90-R дозволило встановити, що серед хворих на психогенні депресивні розлади емігрантів (196 осіб) були значуще вищими у порівнянні з реемігрантами (191 особа) та не емігрантами (198 осіб) показники за шкалами соматизації (відповідно 0,87±0,53 балів, 0,66±0,40 балів та 0,51±0,34 балів), обсесивно-компульсивних розладів (1,43±0,77 балів, 1,13±0,44 балів та 0,98±0,48 балів), тривожності (1,73±1,07) балів, 1,32±0,84 балів та 1,07±0,98 балів), а у реемігрантів – депресії (2,98±0,35 балів, у емігрантів 2,61±0,59 балів, у не емігрантів 2,40±0,45 балів) та міжособистісної сенситивності (відповідно 1,24±0,33 балів, 1,15±0,35 балів та 0,95±0,29 балів), а також індекс виразності дистресу (2,45±0,23 балів, 2,40±0,42 балів та 2,25±0,29 балів). У хворих на ендогенні депресивні розлади вплив фактора еміграції виявився меншим, однак загальні тенденції зберігаються: у емігрантів є найбільшою виразність проявів соматизації (1,17±0,83 балів, у реемігрантів 0,83±0,48 балів, у не емігрантів 0,77±0,70 балів), тривожності (відповідно 1,90±1,10 балів, 1,47±0,97 балів та 1,14±1,01 балів), обсесивно-компульсивних розладів (відповідно 1,54±0,66 балів, 1,34±0,52 балів та 1,07±0,44 балів) та фобічної тривожності (відповідно 0,76±0,44 балів, 0,68±0,23 балів та 0,67±0,40 балів), а у реемігрантів – депресії (3,18±0,26 балів, у емігрантів 2,79±0,42 балів, у не емігрантів 2,63±0,30 балів), міжособистісної сенситивності (1,36±0,45 балів, у не емігрантів 1,10±0,32 бали, у емігрантів 1,07±0,49 балів) та індекс виразності дистресу (2,60±0,16 балів, у емігрантів 2,53±0,34 балів, у не емігрантів 2,30±0,28 балів). У хворих на органічні депресивні розлади виявлені більш складні закономірності, зумовлені характером депресії: значущі розбіжності у показниках між групами емігрантів, реемігрантів та не емігрантів виявлені за соматизацією (відповідно 1,33±0,68 балів, 0,93±0,32 балів та 0,91±0,64 балів), тривожністю (відповідно 1,99±0,67 балів, 1,68±0,60 балів та 1,43±1,03 балів), фобічною тривожністю (0,91±0,45 балів, 0,75±0,31 балів та 0,66±0,39 балів) та обсесивно-компульсивними розладами (відповідно 1,10±0,63 балів, 1,49±0,51 балів та 1,25±0,61 балів). Показники за депресією та міжособистісною сенситивністю є найвищими у реемігрантів (відповідно 3,16±0,48 балів та 1,43±0,40 балів), меншими у емігрантів (відповідно 2,92±0,41 балів та 1,21±0,34 балів), і найменшими – у не емігрантів (відповідно 2,66±0,51 балів та 1,11±0,38 балів). Виявлені закономірності можуть бути пояснені впливом об’єктивних соціально-психологічних факторів.</p>
ОСОБЛИВОСТI ОКРЕМИХ ВИДIВ СПРИЙМАННЯ У ШКОЛЯРIВ ЗI СЛУХОВОЮ ДЕПРИВАЦIЄЮ
Authors: Klishch M. I. , Vadziuk S. N. 
Published: October 2016

<p>Резюме. З використанням комп’ютерної програми «Efecton Studio 2009» досліджено особливості сприймання розміру, простору та часу школярами молодшого, середнього і старшого шкільного віку з нейросенсорною приглухуватістю. Встановлено достовірну різницю показників сприймання школярів усіх вікових періодів, які мали порушення слуху, відносно осіб відповідної вікової групи з нормальним слухом. Показано також вікові відмінності та їх особливості у школярів обох порівнюваних груп. Зроблено висновок, що процес сприймання у школярів з вадами слуху розвивається за тими ж законами, що i сприймання у школярів без порушень слуху, однак специфiка порушення супроводжується несвоєчасним формуванням мiжфункцiональних взаємодiй (мiж сприйманням i мовою), що негативно впливає на розвиток однієї з найскладніших властивостей сприймання – усвiдомленостi, що й призводить до порушень основних видів сприймання.</p><p><br /><br /></p>
Predictability and Decadal Variability of the North Atlantic Ocean State Evaluated from a Realistic Ocean Model
Authors: Sévellec Florian , Fedorov Alexey V. 
Published: October 2016

AbstractThis study investigates the excitation of decadal variability and predictability of the ocean climate state in the North Atlantic. Specifically, initial linear optimal perturbations (LOPs) in temperature and salinity that vary with depth, longitude, and latitude are computed, and the maximum impact on the ocean of these perturbations is evaluated in a realistic ocean general circulation model. The computations of the LOPs involve a maximization procedure based on Lagrange multipliers in a nonautonomous context. To assess the impact of these perturbations four different measures of the North Atlantic Ocean state are used: meridional volume and heat transports (MVT and MHT) and spatially averaged sea surface temperature (SST) and ocean heat content (OHC). It is shown that these metrics are dramatically different with regard to predictability. Whereas OHC and SST can be efficiently modified only by basin-scale anomalies, MVT and MHT are also strongly affected by smaller-scale perturbations. This suggests that instantaneous or even annual-mean values of MVT and MHT are less predictable than SST and OHC. Only when averaged over several decades do the former two metrics have predictability comparable to the latter two, which highlights the need for long-term observations of the Atlantic meridional overturning circulation in order to accumulate climatically relevant data. This study also suggests that initial errors in ocean temperature of a few millikelvins, encompassing both the upper and deep ocean, can lead to ~0.1-K errors in the predictions of North Atlantic sea surface temperature on interannual time scales. This transient error growth peaks for SST and OHC after about 6 and 10 years, respectively, implying a potential predictability barrier.
Interannual Variation of the Cold-Season Rainfall Center in the South China Sea
Authors: Chen Tsing-Chang , Tsay Jenq-Dar , Matsumoto Jun 
Published: October 2016

AbstractDuring 15 November–31 December, a cold-season rainfall center appears in the southern part of the South China Sea (SCS) north of northwestern Borneo and juxtaposed along the southwest–northeast direction with rainfall centers for the Malay Peninsula and the Philippines. This SCS rainfall center also coincides geographically with the SCS surface trough. An effort is made to explore the formation mechanism of this rainfall center. It is primarily formed by the second intensification of heavy rainfall/flood cold surge vortex [CSV(HRF)] through its interaction with a cold surge flow over the SCS trough. Both the SCS rainfall center and the SCS surface trough are located at the easterly flow north of the near-equator trough. Modulated by the interannual variation of the cyclonic shear flow along the near-equator trough in concert with the El Niño–Southern Oscillation (ENSO) cycle, the SCS rainfall center undergoes an interannual variation. The impact of this ENSO cycle is accomplished through the regulation of CSV(HRF) trajectories originating from the Philippines vicinity and Borneo and propagating to different destinations. Rain-producing efficiency determined by the interannual variation of the divergent circulation accompanies the cyclonic shear flow around the near-equator trough in response to this ENSO cycle.
Simulation of Late Summer Arctic Clouds during ASCOS with Polar WRF
Authors: Hines Keith M. , Bromwich David H. 
Published: October 2016

AbstractLow-level clouds are extensive in the Arctic and contribute to inadequately understood feedbacks within the changing regional climate. The simulation of low-level clouds, including mixed-phase clouds, over the Arctic Ocean during summer and autumn remains a challenge for both real-time weather forecasts and climate models. Here, improved cloud representations are sought with high-resolution mesoscale simulations of the August–September 2008 Arctic Summer Cloud Ocean Study (ASCOS) with the latest polar-optimized version (3.7.1) of the Weather Research and Forecasting (Polar WRF) Model with the advanced two-moment Morrison microphysics scheme. Simulations across several synoptic regimes for 10 August–3 September 2008 are performed with three domains including an outer domain at 27-km grid spacing and nested domains at 9- and 3-km spacing. These are realistic horizontal grid spacings for common mesoscale applications. The control simulation produces excessive cloud liquid water in low clouds resulting in a large deficit in modeled incident shortwave radiation at the surface. Incident longwave radiation is less sensitive. A change in the sea ice albedo toward the larger observed values during ASCOS resulted in somewhat more realistic simulations. More importantly, sensitivity tests show that a reduction in specified liquid cloud droplet number to very pristine conditions increases liquid precipitation, greatly reduces the excess in simulated low-level cloud liquid water, and improves the simulated incident shortwave and longwave radiation at the surface.
Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs
Authors: Lerche Stefanie , Brockmann Kathrin , Pilotto Andrea , Wurster Isabel , Sünkel Ulrike , Hobert Markus A. , von Thaler Anna-Katharina , Schulte Claudia , Stoops Erik , Vanderstichele Hugo , Herbst Victor , Brix Britta , Eschweiler Gerhard W. , Metzger Florian G. , Maetzler Walter , Berg Daniela 
Published: October 2016

AbstractBackgroundMild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS.MethodsFrom the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1–40and Aβ1–42were evaluated longitudinally.ResultsIn 52 (11 %) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1–42were significantly lower than those of controls, and declined more rapidly over time.ConclusionsThis longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1–42, possibly indicating an ongoing neurodegenerative process.