bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortgage Debt Overhang: Reduced Investment by Homeowners at Risk of Default
Authors: MELZER BRIAN T. 
Published: January 2017

ABSTRACTHomeowners at risk of default face a debt overhang that reduces their incentive to invest in their property: in expectation, some value created by investments in the property will go to the lender. This agency conflict affects housing investments. Homeowners at risk of default cut back substantially on home improvements and mortgage principal payments, even when they appear financially unconstrained. Meanwhile, they do not reduce spending on assets that they may retain in default, including home appliances, furniture, and vehicles. These findings highlight an important financial friction that has stifled housing investment since the Great Recession.
Politically Connected Private Equity and Employment
Authors: FACCIO MARA , HSU HUNG‐CHIA 
Published: January 2017

ABSTRACTWe investigate the employment consequences of private equity buyouts. We find evidence of higher job creation, on average, at the establishments operated by targets of politically connected private equity firms than at those operated by targets of nonconnected private equity firms. Consistent with an exchange of favors story, establishments operated by targets of politically connected private equity firms increase employment more during election years and in states with high levels of corruption. In additional analyses, we provide evidence of specific benefits experienced by target firms from their political connections. Our results are robust to tests designed to mitigate selection concerns.
Asset Market Participation and Portfolio Choice over the Life‐Cycle
Authors: FAGERENG ANDREAS , GOTTLIEB CHARLES , GUISO LUIGI 
Published: January 2017

ABSTRACTUsing error‐free data on life‐cycle portfolio allocations of a large sample of Norwegian households, we document a double adjustment as households age: a rebalancing of the portfolio composition away from stocks as they approach retirement and stock market exit after retirement. When structurally estimating an extended life‐cycle model, the parameter combination that best fits the data is one with a relatively large risk aversion, a small per‐period participation cost, and a yearly probability of a large stock market loss in line with the frequency of stock market crashes in Norway.
Conserved two‐component Hik34‐Rre1 module directly activates heat‐stress inducible transcription of major chaperone and other genes in Synechococcus elongatusPCC 7942
Authors: Kobayashi Ikki , Watanabe Satoru , Kanesaki Yu , Shimada Tomohiro , Yoshikawa Hirofumi , Tanaka Kan 
Published: January 2017

SummaryBacteria and other organisms, including cyanobacteria, employ two‐component signal transducing modules comprising histidine kinases and response regulators to acclimate to changing environments. While the number and composition of these modules differ among cyanobacteria, two response regulators that contain DNA binding domains, RpaB and Rre1, are conserved in all sequenced cyanobacterial genomes and are essential for viability. Although RpaB negatively or positively regulates high light and other stress‐responsive gene expression, little is known about the function of Rre1. Here, they investigated the direct regulatory targets of Rre1 in the cyanobacterium Synechococcus elongatus PCC 7942. Chromatin immunoprecipitation and high‐density tiling array analysis were used to map Rre1 binding sites. The sites included promoter regions for chaperone genes such as dnaK2, groESL‐1, groEL‐2, hspA and htpG, as well as the group 2 sigma factor gene rpoD2. In vivo and in vitro analyses revealed that Rre1 phosphorylation level, DNA binding activity and adjacent gene transcription increased in response to heat stress. These responses were much diminished in a knock‐out mutant of Hik34, a previously identified heat shock regulator. Based on our results, we propose Hik34‐Rre1 is the heat shock‐responsive signaling module that positively regulates major chaperone and other genes in cyanobacteria.
Phlebotomine sandfly ecology on the Indian subcontinent: does village vegetation play a role in sandfly distribution in Bihar, India?
Authors: POCHÉ D. M. , POCHÉ R. M. , MUKHERJEE S. , FRANCKOWIAK G. A. , BRILEY L. N. , SOMERS D. J. , GARLAPATI R. B. 
Published: January 2017

AbstractVisceral leishmaniasis (VL) is a disease that results in approximately 50 000 human deaths annually. It is transmitted through the bites of phlebotomine sandflies and around two‐thirds of cases occur on the Indian subcontinent. Indoor residual spraying (IRS), the efficacy of which depends upon sandfly adults resting indoors, is the only sandfly control method used in India. Recently, in Bihar, India, considerable sandfly numbers have been recorded outdoors in village vegetation, which suggests that IRS may control only a portion of the population. The purpose of this study was to revisit previously published results that suggested some sandflies to be arboreal and to rest on outlying plants by using Centers for Disease Control light traps to capture sandflies in vegetation, including banana plants and palmyra palm trees, in two previously sampled VL‐endemic Bihari villages. Over 3500 sandflies were trapped in vegetation over 12 weeks. The results showed the mean number of sandflies collected per trap night were significantly higher in banana trees than in other vegetation (P = 0.0141) and in female rather than male palmyra palm trees (P = 0.0002). The results raise questions regarding sandfly dispersal, oviposition and feeding behaviours, and suggest a need to refine current control practices in India and to take into account an evolving understanding of sandfly ecology.
Desmopressin (Octostim®) before a native kidney biopsy can reduce the risk for biopsy complications in patients with impaired renal function: A pilot study
Authors: Peters Björn , Hadimeri Henrik , Mölne Johan , Nasic Salmir , Jensen Gert , Stegmayr Bernd 
Published: January 2017

AbstractAimTo evaluate whether the administration of desmopressin alters the risk for renal biopsy complications.MethodsA multicenter registry containing 576 native kidney biopsies (NKb) with a serum creatinine above 150 μmol/L in 527 patients (372 men and 155 women, median age 61 years) was used. Most of the data were prospective. At one of the hospitals all biopsies with creatinine above 150 μmol/L received desmopressin before biopsies (NKb 204). These were compared to outcome of biopsy complications against other centres where desmopressin was not given (NKb 372). Fisher's exact test, χ2 analyses, univariate and multiple binary logistic regression were used. Data were given as odds ratio (OR) and confidence interval (CI). A two sided P‐value of <0.05 was considered significant.ResultsIn NKb with creatinine >150 μmol/L, those with desmopressin had less overall (3.4% vs 8.4%, OR 0.39, CI 0.17–0.90) whereas major or minor complications were not different. While desmopressin did not exhibit difference in complications in men, women received less major (0% vs 8.6%, P = 0.03) and overall complications (0% vs 12.1%, P = 0.006). A multiple logistic regression revealed that, after adjusting for BMI, age and sex, prophylaxis with desmopressin showed less major (OR 0.38, CI 0.15–0.96) and overall complications (OR 0.36, CI 0.15–0.85).ConclusionDesmopressin given before a native kidney biopsy in patients with impaired renal function can reduce the risk for complications.
Autumn photosynthetic decline and growth cessation in seedlings of white spruce are decoupled under warming and photoperiod manipulations
Authors: Stinziano Joseph R. , Way Danielle A. 
Published: January 2017

AbstractClimate warming is expected to increase the seasonal duration of photosynthetic carbon fixation and tree growth in high‐latitude forests. However, photoperiod, a crucial cue for seasonality, will remain constant, which may constrain tree responses to warming. We investigated the effects of temperature and photoperiod on weekly changes in photosynthetic capacity, leaf biochemistry and growth in seedlings of a boreal evergreen conifer, white spruce [Picea glauca (Moench) Voss]. Warming delayed autumn declines in photosynthetic capacity, extending the period when seedlings had high carbon uptake. While photoperiod was correlated with photosynthetic capacity, short photoperiods did not constrain the maintenance of high photosynthetic capacity under warming. Rubisco concentration dynamics were affected by temperature but not photoperiod, while leaf pigment concentrations were unaffected by treatments. Respiration rates at 25 °C were stimulated by photoperiod, although respiration at the growth temperatures was increased in warming treatments. Seedling growth was stimulated by increased photoperiod and suppressed by warming. We demonstrate that temperature is a stronger control on the seasonal timing of photosynthetic down‐regulation than is photoperiod. Thus, while warming can stimulate carbon uptake in boreal conifers, the extra carbon may be directed towards respiration rather than biomass, potentially limiting carbon sequestration under climate change.
A possible role for flowering locus T‐encoding genes in interpreting environmental and internal cues affecting olive (Olea europaea L.) flower induction
Authors: Haberman Amnon , Bakhshian Ortal , Cerezo‐Medina Sergio , Paltiel Judith , Adler Chen , Ben‐Ari Giora , Mercado Jose Angel , Pliego‐Alfaro Fernando , Lavee Shimon , Samach Alon 
Published: January 2017

AbstractOlive (Olea europaea L.) inflorescences, formed in lateral buds, flower in spring. However, there is some debate regarding time of flower induction and inflorescence initiation. Olive juvenility and seasonality of flowering were altered by overexpressing genes encoding flowering locus T (FT). OeFT1 and OeFT2 caused early flowering under short days when expressed in Arabidopsis. Expression of OeFT1/2 in olive leaves and OeFT2 in buds increased in winter, while initiation of inflorescences occurred i n late winter. Trees exposed to an artificial warm winter expressed low levels of OeFT1/2 in leaves and did not flower. Olive flower induction thus seems to be mediated by an increase in FT levels in response to cold winters. Olive flowering is dependent on additional internal factors. It was severely reduced in trees that carried a heavy fruit load the previous season (harvested in November) and in trees without fruit to which cold temperatures were artificially applied in summer. Expression analysis suggested that these internal factors work either by reducing the increase in OeFT1/2 expression or through putative flowering repressors such as TFL1. With expected warmer winters, future consumption of olive oil, as part of a healthy Mediterranean diet, should benefit from better understanding these factors.
Thoracic ultrasound recognition of competence: A position paper of the Thoracic Society of Australia and New Zealand
Authors: Williamson Jonathan P. , Twaddell Scott H. , Lee Y.C. Gary , Salamonsen Matthew , Hew Mark , Fielding David , Nguyen Phan , Steinfort Daniel , Hopkins Peter , Smith Nicola , Grainge Christopher 
Published: January 2017

ABSTRACTThe ability to perform bedside thoracic ultrasound is increasingly recognized as an essential skill for thoracic clinicians, extending the clinical examination and aiding diagnostic and therapeutic procedures. Thoracic ultrasound reduces complications and increases success rates when used prior to thoracentesis or intercostal chest tube insertion. It is increasingly difficult to defend performing these procedures without real or near‐real time image guidance. To assist thoracic physicians and others achieve and demonstrate thoracic ultrasound competence, the Interventional Pulmonology Special Interest Group (IP‐SIG) of the Thoracic Society of Australia and New Zealand (TSANZ) has developed a new pathway with four components: (i) completion of an approved thoracic ultrasound theory and hands‐on teaching course. (ii) A log of at least 40 relevant scans. (iii) Two formative assessments (following 5–10 scans and again after 20 scans) using the Ultrasound‐Guided Thoracentesis Skills and Tasks Assessment Tool (UG‐STAT). (iv) A barrier assessment (UG‐STAT, pass score of 90%) by an accredited assessor not directly involved in the candidate's training. Upon completion of these requirements a candidate may apply to the TSANZ for recognition of competence. This pathway is intended to provide a regional standard for thoracic ultrasound training.
Diagnostic value of endobronchial ultrasound elastography for the differentiation of benign and malignant intrathoracic lymph nodes
Authors: Korrungruang Potjanee , Boonsarngsuk Viboon 
Published: January 2017

ABSTRACT
Background and objectiveEndobronchial ultrasound (EBUS) findings can be used for benign/malignant differentiation of lymph nodes (LNs). Recently, EBUS elastography has been introduced as a complementary modality in the evaluation of intrathoracic lymphadenopathy. We evaluated the ability of EBUS elastography to differentiate between benign and malignant LNs.MethodsA prospective study was conducted on patients sent for evaluation of intrathoracic lymphadenopathy. LNs were classified qualitatively according to elastographic colour pattern: type 1, predominantly non‐blue; type 2, partly blue, partly non‐blue and type 3, predominantly blue. Quantitative elastography of LNs was measured by the strain ratio (SR). Qualitative and quantitative elastographies were compared for the final diagnosis of LNs.ResultsThere were 120 LNs from 72 patients who underwent EBUS elastography. The final diagnosis included 96 malignant and 24 benign LNs. All of the 16 type 1 LNs proved to be benign diseases, while 95 of the 101 type 3 LNs were finally diagnosed as malignancies. Three LNs classified as type 2 proved to be two benign and one malignant. Malignant LNs presented a higher median SR than benign LNs (73.50 vs 1.29, P = 0.001). An SR of >2.5 and non‐type 1 elastographic pattern achieved similar diagnostic performance in benign/malignant differentiation (sensitivity, 100% vs 100%; specificity, 70.8% vs 66.7%; positive predictive value, 93.2% vs 92.3%; negative predictive value, 100% vs 100%).Conclusion
EBUS elastography is a promising diagnostic modality for the differentiation of benign and malignant LNs during EBUS‐guided transbronchial needle aspiration (TBNA). Qualitative and quantitative EBUS elastographies provide similar diagnostic performance.
The DC1‐domain protein VACUOLELESS GAMETOPHYTES is essential for development of female and male gametophytes in Arabidopsis
Authors: D'Ippólito Sebastián , Arias Leonardo Agustín , Casalongué Claudia Anahí , Pagnussat Gabriela Carolina , Fiol Diego Fernando 
Published: January 2017

SummaryIn this work we identified VACUOLELESS GAMETOPHYTES (VLG) as a DC1 domain‐containing protein present in the endomembrane system and essential for development of both female and male gametophytes. VLG was originally annotated as a gene coding for a protein of unknown function containing DC1 domains. DC1 domains are cysteine‐ and histidine‐rich zinc finger domains found exclusively in the plant kingdom that have been named on the basis of similarity with the C1 domain present in protein kinase C (PKC). In Arabidopsis, both male and female gametophytes are characterized by the formation of a large vacuole early in development; this is absent in vlg mutant plants. As a consequence, development is arrested in embryo sacs and pollen grains at the first mitotic division. VLG is specifically located in multivesicular bodies or pre‐vacuolar compartments, and our results suggest that vesicular fusion is affected in the mutants, disrupting vacuole formation. Supporting this idea, AtPVA12 – a member of the SNARE vesicle‐associated protein family and previously related to a sterol‐binding protein, was identified as a VLG interactor. A role for VLG is proposed mediating vesicular fusion in plants as part of the sterol trafficking machinery required for vacuole biogenesis in plants.
Reviewer Acknowledgements
Authors: Young James 
Published: January 2017

International Journal of Social Science Studies (IJSSS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJSSS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 5, Number 2 Abdul Azim Akhtar, Institute of Objective Studies, IndiaAgboola O. Paul, Universiti Teknologi Malaysia, MalaysiaAnastasia Panagakos, Cosumnes River College, USAAntónio Calha, Polytechnic Institute of Portalegre, PortugalBegoña Montero-Fleta, Universitat Politécnica de València, SpainE.Ozan Aksoz, Anadolu University, TurkeyEmanuele Achino, C. D. T. O., ItalyHenry Poduthas, West Texas A&M University, USAJehu Onyekwere Nnaji, University of Naples II, Italy and Globe Visions Network, ItalyK. O. Aramide, The Polytechnic Ibadan, NigeriaKatja Eman, Univerza v Mariboru, SloveniaLaura Diaconu Maxim, "Alexandru Ioan Cuza University" of Iasi, RomaniaLuigia Simona Sica, University of Naples “Federico II”, ItalyMałgorzata Haładewicz, Opole University of Technology, PolandRasa Poceviciene, Siauliai University, LithuaniaRaymond Chan, City University of Hong Kong, Hong KongSandro Serpa, University of the Azores, Portugal James YoungEditorial AssistantOn behalf of,The Editorial Board of International Journal of Social Science StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://ijsss.redfame.com
Draft Genome Sequence of the Acidophilic, Halotolerant, and Iron/Sulfur-Oxidizing Acidihalobacter prosperus DSM 14174 (Strain V6)
Authors: Khaleque Himel Nahreen , Ramsay Joshua P. , Murphy Riley J. T. , Kaksonen Anna H. , Boxall Naomi J. , Watkin Elizabeth L. J. 
Published: January 2017

ABSTRACT

The principal genomic features of
Acidihalobacter prosperus
DSM 14174 (strain V6) are presented here. This is a mesophilic, halotolerant, and iron/sulfur-oxidizing acidophile that was isolated from seawater at Vulcano, Italy. It has potential for use in biomining applications in regions where high salinity exists in the source water and ores.
Selecting patients with non-ST-elevation acute coronary syndrome for coronary angiography: a nationwide clinical vignette study in the Netherlands
Authors: Engel Josien , Poldervaart Judith M , van der Wulp Ineke , Reitsma Johannes B , de Bruijne Martine C , Bunge Jeroen J H , Cramer Maarten J , Tietge Wouter J , Uijlings Ruben , Wagner Cordula 
Published: January 2017

ObjectiveCardiac guidelines recommend that the decision to perform coronary angiography (CA) in patients with Non-ST-Elevation Acute Coronary Syndrome (NST-ACS) is based on multiple factors. It is, however, unknown how cardiologists weigh these factors in their decision-making. The aim was to investigate the importance of different clinical characteristics, including information derived from risk scores, in the decision-making of Dutch cardiologists regarding performing CA in patients with suspected NST-ACS.DesignA web-based survey containing clinical vignettes.Setting and participantsRegistered Dutch cardiologists were approached to complete the survey, in which they were asked to indicate whether they would perform CA for 8 vignettes describing 7 clinical factors: age, renal function, known coronary artery disease, persistent chest pain, presence of risk factors, ECG findings and troponin levels. Cardiologists were divided into two groups: group 1 received vignettes ‘without’ a risk score present, while group 2 completed vignettes ‘with’ a risk score present.Results129 (of 946) cardiologists responded. In both groups, elevated troponin levels and typical ischaemic changes (p<0.001) made cardiologists decide more often to perform CA. Severe renal dysfunction (p<0.001) made cardiologists more hesitant to decide on CA. Age and risk score could not be assessed independently, as these factors were strongly associated. Inspecting the factors together showed, for example, that cardiologists were more hesitant to perform CA in elderly patients with high-risk scores than in younger patients with intermediate risk scores.ConclusionsWhen deciding to perform in-hospital CA (≤72 hours after patient admission) in patients with suspected NST-ACS, cardiologists tend to rely mostly on troponin levels, ECG changes and renal function. Future research should focus on why CA is less often recommended in patients with severe renal dysfunction, and in elderly patients with high-risk scores. In addition, the impact of age and risk score on decision-making should be further investigated.
Training mid-career internists to perform high-quality colonoscopy: a pilot training programme to meet increasing demands for colonoscopy
Authors: Shah-Ghassemzadeh Nicole K , Jackson Christian S , Juma David , Strong Richard M 
Published: January 2017

ABSTRACTBackgroundColorectal cancer (CRC) is the second leading cause of cancer deaths in the USA. Despite a recent rise in CRC screening there remains an increasing demand for colonoscopy, yet a limited supply of gastroenterologists who can meet this need.ObjectiveTo determine if a mid-career general internist (GIN) could be trained to perform high-quality colonoscopes via an intensive training programme.DesignA GIN trained 2–3 days/week, 4–5 hours/day, for 7 months with an experienced gastroenterologist. Their independent performance was then compared with that of a gastroenterology attending (GA), with and without a gastroenterology fellow (GF).Main measuresThe primary outcome was to compare caecal intubation rates, adenoma detection rates (ADRs), interval CRC rates and complications between the three groups.Key results989 patients were initially included in the study, and 818 were included in the final analysis. Caecal intubation rates were 95%, 94% and 93% for the GIN, GA+GF and GA, respectively (p=0.31). The overall polyp detection rates were 68%, 39% and 44% among the GIN, GA+GF and GA, respectively (p&lt;0.0001). The ADRs were 56%, 33% and 34% for the GIN, GA+GF and GA, respectively (p&lt;0.0001). Three complications occurred, all within the GA group. No interval cancers were diagnosed within a 5-year surveillance period, across all three groups.ConclusionsThe GIN attained high success rates in all quality measures. Training mid-career GINs to perform high-quality screening colonoscopes, through a standardised curriculum, may be a reasonable approach to address the growing demand for colonoscopists.
Mining Top-K Click Stream Sequences Patterns
Authors: Haj Ali MEHDI , Zhu Qun-Xiong , He Yan-Lin 
Published: January 2017

<p><em>Sequential pattern mining, it is not just important in data mining field , but it is the basis of many applications .However, running applications cost time and memory, especially when dealing with dense of the dataset. Setting the proper minimum support threshold is one of the factors that consume more memory and time. However , it is difficult for users to get the appropriate patterns, it may present too many sequential patterns and makes it difficult for users to comprehend the results. The problem becomes worse and worse when dealing with long click stream sequences or huge dataset. As a solution, we developed an efficient algorithm, called TopK (Top-K click stream sequence pattern mining), which employs the output as top-k patterns , K is the most important and relevant frequencies (with a high support) . However ,our algorithm based on pseudo-projection to avoid consuming more time and memory, and uses several efficient search space pruning methods together with BI-Directional Extension. Our extensive study and experiments on real click stream datasets show TopK significantly outperforms the previous algorithms.</em></p>