bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelvic vein embolisation of gonadal and internal iliac veins can be performed safely and with good technical results in an ambulatory vein clinic, under local anaesthetic alone – Results from two years' experience
Authors: Whiteley Mark S , Lewis-Shiell Chiyinde , Bishop Sophia I , Davis Eluned L , Fernandez-Hart Tim J , Diwakar Previn , Beckett David 
Published: October 2017

Objectives Pelvic vein embolisation is increasing in venous practice for the treatment of conditions associated with pelvic venous reflux. In July 2014, we introduced a local anaesthetic “walk-in walk-out” pelvic vein embolisation service situated in a vein clinic, remote from a hospital. Methods Prospective audit of all patients undergoing pelvic vein embolisation for pelvic venous reflux. All patients had serum urea and electrolytes tested before procedure. Embolisation coils used were interlock embolisation coils (Boston Scientific, USA) as they can be repositioned after deployment and before release. We noted (1) complications during or post-procedure (2) successful abolition of pelvic venous reflux on transvaginal duplex scanning (3) number of veins (territories) treated and number of coils used. Results In 24 months, 121 patients underwent pelvic vein embolisation. Three males were excluded as transvaginal duplex scanning was impossible and six females excluded due to lack of complete data. None of these nine had any complications. Of 112 females analysed, mean age 45 years (24–71), 104 were for leg varices, 48 vulval varices and 20 for pelvic congestion syndrome (some had more than one indication). There were no deaths or serious complications to 30 days. Two procedures were abandoned, one completed subsequently and one was technically successful on review. One more had transient bradycardia and one had a coil removed by snare during the procedure. The mean number of venous territories treated was 2.9 and a mean of 3.3 coils was used per territory. Conclusion Pelvic vein embolisation under local anaesthetic is safe and technically effective in a remote out-patient facility outside of a hospital.
Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl– co-transporter in electrolyte fluxes in an in vitro blood–brain barrier model of dehydration
Authors: Lykke Kasper , Assentoft Mette , Hørlyck Sofie , Helms Hans CC , Stoica Anca , Toft-Bertelsen Trine L , Tritsaris Katerina , Vilhardt Frederik , Brodin Birger , MacAulay Nanna 
Published: October 2017

The blood–brain barrier (BBB) is involved in brain water and salt homeostasis. Blood osmolarity increases during dehydration and water is osmotically extracted from the brain. The loss of water is less than expected from pure osmotic forces, due to brain electrolyte accumulation. Although the underlying molecular mechanisms are unresolved, the current model suggests the luminally expressed Na+-K+-2Cl− co-transporter 1 (NKCC1) as a key component, while the role of the Na+/K+-ATPase remains uninvestigated. To test the involvement of these proteins in brain electrolyte flux under mimicked dehydration, we employed a tight in vitro co-culture BBB model with primary cultures of brain endothelial cells and astrocytes. The Na+/K+-ATPase and the NKCC1 were both functionally dominant in the abluminal membrane. Exposure of the in vitro BBB model to conditions mimicking systemic dehydration, i.e. hyperosmotic conditions, vasopressin, or increased [K+]o illustrated that NKCC1 activity was unaffected by exposure to vasopressin and to hyperosmotic conditions. Hyperosmotic conditions and increased K+ concentrations enhanced the Na+/K+-ATPase activity, here determined to consist of the α1 β1 and α1 β3 isozymes. Abluminally expressed endothelial Na+/K+-ATPase, and not NKCC1, may therefore counteract osmotic brain water loss during systemic dehydration by promoting brain Na+ accumulation.
Outcomes After Operative and Nonoperative Treatment of Proximal Hamstring Avulsions: A Systematic Review and Meta-analysis
Authors: Bodendorfer Blake M. , Curley Andrew J. , Kotler Joshua A. , Ryan James M. , Jejurikar Neha S. , Kumar Anagha , Postma William F. 
Published: October 2017

Background: No meta-analysis has compared outcomes of operative and nonoperative proximal hamstring avulsion treatment. Purpose: To compare outcomes of operative and nonoperative proximal hamstring avulsion treatment, including acute, chronic, partial, and complete repairs. Study Design: Meta-analysis. Methods: PubMed, CINAHL, SPORTdiscus, Cochrane Library, EMBASE, and Web of Science were searched up to July 2016. Three authors screened the studies and performed quality assessment using criteria from the Methodologic Index for Nonrandomized Studies. A best evidence synthesis was subsequently used. Results: Twenty-four studies (795 proximal hamstring avulsions) were included. Twenty-two studies included proximal hamstring avulsion repairs; 1 study had proximal hamstring avulsion repairs and a control group of nonoperatively treated proximal hamstring avulsions; and 1 study had solely nonoperatively treated proximal hamstring avulsions. The majority of studies were of low methodological quality. Overall, repairs had significantly higher patient satisfaction (90.81% vs 52.94%), hamstring strength (85.01% vs 63.95%), Lower Extremity Functional Scale scores (72.77 vs 69.53), and single-legged hop test results (119.1 vs 56.62 cm) (all P < .001); complications occurred in 23.17% of cases. Compared with chronic repairs, acute avulsion repairs had greater patient satisfaction (95.48% vs 83.79%), less pain (1.07 vs 3.71), and greater strength (85.2% vs 82.8%), as well as better scores for the Lower Extremity Functional Scale (75.64 vs 71.5), UCLA activity scale (University of California, Los Angeles; 8.57 vs 8.10), and Single Assessment Numeric Evaluation (93.36 vs 86.50) (all P < .001). Compared with partial avulsion repairs, complete avulsion repairs had higher patient satisfaction (89.64% vs 81.35%, P < .001), less pain (1.87 vs 4.60, P < .001), and higher return to sport or preinjury activity level, but this was insignificant (81.43% vs 73.83%, P = .082). Partial avulsion repairs had better hamstring strength (86.04% vs 83.71%, P < .001) and endurance (107.13% vs 100.17%, P < .001). Complete repairs had significantly higher complication rates (29.38% vs 11.27%, P = .001). Conclusion: Proximal hamstring avulsion repair resulted in superior outcomes as compared with nonoperative treatment, although the complication rate was 23.17%. The nonoperative group was quite small, making a true comparison difficult. Acute repairs have better outcomes than do chronic repairs. Complete avulsion repairs had higher patient satisfaction, less pain, and a higher complication rate than partial avulsion repairs, although partial avulsion repairs had better hamstring strength and endurance. Studies of high methodological quality are lacking in terms of investigating the outcomes of proximal hamstring avulsion repairs.
Treatment of a burn animal model with functionalized tridimensional electrospun biomaterials
Authors: Steffens Daniela , Mathor Monica Beatriz , Soster Paula Rigon da Luz , Vergani Gustavo , Luco Dayane Piffer , Pranke Patricia 
Published: October 2017

Laminin-functionalized poly-d,l-lactic acid scaffolds were produced. Following this, mesenchymal stem cells and keratinocytes were seeded on biomaterials for the in vivo experiments, where the biomaterials with or without cells were implanted. The analysis is comprised of the visual aspect and mean size of the lesion plus the histology and gene expression. The results showed that the cells occupied all the structure of the scaffolds in all the groups. After nine days of in vivo experiments, the defect size did not show statistical difference among the groups, although the groups with the poly-d,l-lactic acid/Lam biomaterial had the lowest lesion size and presented the best visual aspect of the wound. Gene expression analysis showed considerable increase of tumor growth factor beta 1 expression, increased vascular endothelial growth factor and balance of the BAX/Bcl-2 ratio when compared to the lesion group. Histological analysis showed well-formed tissue in the groups where the biomaterials and biomaterials plus cells were used. In some animals, in which biomaterials and cells were used, the epidermis was formed throughout the length of the wound. In conclusion, these biomaterials were found to be capable of providing support for the growth of cells and stimulated the healing of the skin, which was improved by the use of cells.
Development of a stress-based creep-fatigue equation: Accommodating pure-fatigue to pure-creep for the high-cycle loading regime
Authors: Liu Dan , Pons Dirk J 
Published: October 2017

Background The creep-fatigue damage in low-cycle regime has been described by a strain-based creep-fatigue equation through integrating creep effect into fatigue damage. Need There is a need to develop a creep-fatigue equation which describes the stress-controlled creep-fatigue behaviour in high-cycle regime. Approach This stress-based creep-fatigue equation was developed through superposing a fatigue mechanism with a creep mechanism. This creep-fatigue equation was then validated on GP91 casting steel. The creep-fatigue data were transformed to the reference condition and collapsed into one power-law curve with good quality. Outcomes This result verified the formulas of the fatigue component and the creep component, and demonstrated the method of extracting the coefficients. The full-range characteristic of this creep-fatigue equation is discussed. In addition, the introduction of the compatibility presents a better description of the reference condition. Originality A new creep-fatigue equation is provided with demonstrably good ability to cover the full range of conditions from the pure-fatigue condition to the pure-creep condition for the high-cycle regime. The method of extracting the coefficients is also provided.
Correlation of Hallux Rigidus Grade With Motion, VAS Pain, Intraoperative Cartilage Loss, and Treatment Success for First MTP Joint Arthrodesis and Synthetic Cartilage Implant
Authors: Baumhauer Judith F. , Singh Dishan , Glazebrook Mark , Blundell Chris M. , De Vries Gwyneth , Le Ian L. D. , Nielsen Dominic , Pedersen M. Elizabeth , Sakellariou Anthony , Solan Matthew , Wansbrough Guy , Younger Alastair S. E. , Daniels Timothy R. 
Published: October 2017

Background: Grading systems are used to assess severity of any condition and as an aid in guiding treatment. This study examined the relationship of baseline motion, pain, and observed intraoperative cartilage loss with hallux rigidus grade. Methods: A prospective, randomized study examining outcomes of arthrodesis compared to synthetic cartilage implant was performed. Patients underwent preoperative clinical examination, radiographic assessment, hallux rigidus grade assignment, and intraoperative assessment of cartilage loss. Visual analog scale (VAS) score for pain was obtained preoperatively and at 24 months. Correlation was made between active peak dorsiflexion, VAS pain, cartilage loss, and hallux rigidus grade. Fisher’s exact test was used to assess grade impact on clinical success ( P < .05). Results: In 202 patients, 59 (29%), 110 (55%), and 33 (16%) were classified as Coughlin grades 2, 3, and 4, respectively. There was no correlation between grade and active peak dorsiflexion (–0.069, P = .327) or VAS pain (–0.078, P = .271). Rank correlations between grade and cartilage loss were significant, but correlations were small. When stratified by grade, composite success rates between the 2 treatments were nearly identical. Conclusions: Irrespective of the grade, positive outcomes were demonstrated for both fusion and synthetic cartilage implant. Clinical symptoms and signs should be used to guide treatment, rather than a grade consisting of radiographic, symptoms, and range of motion factors. Level of Evidence: Level II, randomized clinical trial.
The Effect of Peroneal Muscle Strength on Functional Outcomes After the Modified Broström Procedure for Chronic Ankle Instability
Authors: Cho Byung-Ki , Park Ji-Kang , Choi Seung-Myung , SooHoo Nelson F. 
Published: October 2017

Background: Although the peroneal muscles are known to be the major dynamic lateral stabilizers of the ankle, little information is available regarding the change in muscle strength and relation with the outcomes after lateral ligament repair surgery. The purpose of this study was to identify the effects of peroneal strength on the validated functional outcome measures after the modified Broström procedure (MBP) for chronic ankle instability. Methods: Forty-one patients (41 ankles) who underwent MBP using suture anchors were eligible and followed up to 2 years postoperatively. Functional evaluation consisted of the Foot and Ankle Outcome Score (FAOS), and Foot and Ankle Ability Measure (FAAM). The changes of peroneal strength were evaluated using an isokinetic dynamometer. Differences in the functional outcomes between the 3 groups divided according to the recovery rate of peroneal strength were analyzed. Results: Peak torque and total work for eversion in 60 degrees/s angular velocity significantly improved from a mean 8.1 and 5.2 Nm preoperatively to 11.4 and 6.9 Nm at postoperative 2 years, respectively ( P < .001, P = .038). The deficit ratio of peak torque for eversion significantly improved from a mean 38.6% to 17.4%, and a significant side-to-side difference was found ( P = .011). There were no significant differences in FAOS, FAAM, and measurements of stress radiograph between the 3 groups. Conclusions: Although restoration of peroneal strength postoperatively was about 82.6% of the unaffected ankle, patient-reported function in daily and sport activities were satisfactorily improved. Postoperative isokinetic strength of the peroneals demonstrated no statistically significant effects on the functional outcomes after MBP. Level of Evidence: Level III, prospective comparative case series.
Hylan G-F 20: Review of its Safety and Efficacy in the Management of Joint Pain in Osteoarthritis
Authors: Migliore A. , Giovannangeli F. , Granata M. , Laganà B. 
Published: October 2017

Background Osteoarthritis (OA) is a chronic degenerative joint disease that is a clinically and economically important disease. The increased prevalence of OA with aging, coupled to the demographics of aging populations, make OA a high priority health care problem. Viscosupplementation (VS) is a well-established treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, and could potentially provide a useful alternative in treating such patients with painful OA. Theoretically VS is an approach that should apply to all synovial joints. Objectives The aim of this review is to assess the efficacy and safety of viscosupplementation with Hylan GF-20 (Synvisc®) in the management of joint pain in osteoarthritis. Methods The following databases were searched: Medline, Database of Abstract on Reviews and Effectiveness, Cochrane Database of Systematic Reviews. Furthermore, the lists of references of retrieved publications were manually checked for additional references. The search terms Review, Viscosupplementation, Osteoarthritis, Hyaluronic acid, Hyaluronan, Sodium Hyaluronate, Hylan GF-20, Synvisc, intra-articular injection were used to identify all studies relating to the use of Synvisc® viscosupplementation therapy in OA. Results Hylan GF-20 is a safe and effective treatment for decreasing pain and improving function in patients suffering from knee and hip OA but new evidences are emerging for its use in other joints.
When less is more: From kitchen space assessments to food security for mobile and stationary recreational vehicle dwellers
Authors: McGonagall Odhran M. , Lee Seunghae 
Published: October 2017

This study examined full-time recreational vehicle dwellers in the USA and revealed that mobile and stationary recreational vehicle dwellers were mainly the ‘young-old’ and those entering retirement ages, at an average of 60 years of age. Many recreational vehicle dwellers on limited incomes were found to occupy their recreational vehicles on a permanent basis. Because food security definitions require adequate space for food security, it was assumed that food strategies and food security in limited spaces such as the recreational vehicle might differ among mobile and stationary recreational vehicle dwellers based on their income levels and ability to comply with expected social and cultural standards for housing and recreational vehicle populations. By comparing mobile and stationary recreational vehicle dwellers and further grouping recreational vehicle dwellers as those over and under 65 years of age, this study examined how personal assessments varied in terms of kitchen space, food security and related household food strategies. This study focused on kitchen space assessments and their relation to food security. The stationary full-time occupancy of the recreational vehicles as primary housing is not regulated by law or housing codes. Thus, this study's results will be valuable to understanding aged individuals' housing perceptions and needs in order to provide foundational information for policy and regulation development for alternative housing, such as recreational vehicles and smaller dwellings.
Systematic review on the interaction between office light conditions and occupational health: Elucidating gaps and methodological issues
Authors: van Duijnhoven J. , Aarts M. P. J. , Aries M. B. C. , Rosemann A. L. P. , Kort H. S. M. 
Published: October 2017

Purpose The International Commission on Illumination (CIE) recommends researchers to investigate a wide variety of behavioural and health outcomes. However, researchers often investigate only a part of occupational health (OH) in relation to light. A literature study (2002–2017) regarding the relationship between office lighting conditions and OH was performed to identify gaps and methodological issues. Method The OH outcomes investigated in this paper were grouped according to the International Classification of Diseases and analysed per category: physical and physiological health, mental health, eye health, sleep parameters and visual comfort. Results Findings from the literature study (20 eligible papers) showed that all OH aspects were mostly but not exclusively measured subjectively. Furthermore, most studies investigated only a fraction of office lighting parameters and OH aspects. Conclusions It seems that Correlated Colour Temperature (CCT) and illuminance mainly correlate with OH. However, this may also be explained by gaps and methodological issues in studies described in eligible papers. Based on the literature study, an overview was composed elucidating gaps and methodological issues of office lighting and OH studies. It can be used to design and target the purpose of light and health research.
Post-Crash Neoliberalism in Theory and Practice
Authors: Whitham Ben 
Published: October 2017

Despite the massive state interventions into financial markets following the crash of 2007, the academic literature on the political-economic theory and practice of neoliberalism – a phenomenon often (mis)identified as equivalent to ‘free market’ fundamentalism or a second wave of laissez-faire – has continued to flourish, rather than decline in the post-crash era. This article discusses three recent books that offer insights into the resilience of neoliberalism in theory and practice. While all three books were published shortly before the onset of the new political crisis in the West, represented by Brexit, Trump and the rise of the far right, it is argued, here, that their analyses of post-crash neoliberalism in theory and practice offer useful clues as to what may lie ahead. Ban C (2016) Ruling Ideas: How Global Neoliberalism Goes Local. Oxford University Press: New York, 301pp. Davison S and Harris K (eds) (2015) The Neoliberal Crisis. London: Lawrence & Wishart, 112pp. Hoskins A and Tulloch J (2016) Risk and Hyperconnectivity: Media and Memories of Neoliberalism. New York: Oxford University Press, 333pp.
Meta-analysis of studies comparing oncologic outcomes of radical prostatectomy and brachytherapy for localized prostate cancer
Authors: Cozzi Gabriele , Musi Gennaro , Bianchi Roberto , Bottero Danilo , Brescia Antonio , Cioffi Antonio , Cordima Giovanni , Delor Maurizio , Di Trapani Ettore , Ferro Matteo , Matei Deliu Victor , Russo Andrea , Mistretta Francesco Alessandro , De Cobelli Ottavio 
Published: October 2017

Background: The aim of this study was to compare oncologic outcomes of radical prostatectomy (RP) with brachytherapy (BT). Methods: A literature review was conducted according to the ‘Preferred reporting items for systematic reviews and meta-analyses’ (PRISMA) statement. We included studies reporting comparative oncologic outcomes of RP versus BT for localized prostate cancer (PCa). From each comparative study, we extracted the study design, the number and features of the included patients, and the oncologic outcomes expressed as all-cause mortality (ACM), PCa-specific mortality (PCSM) or, when the former were unavailable, as biochemical recurrence (BCR). All of the data retrieved from the selected studies were recorded in an electronic database. Cumulative analysis was conducted using the Review Manager version 5.3 software, designed for composing Cochrane Reviews (Cochrane Collaboration, Oxford, UK). Statistical heterogeneity was tested using the Chi-square test. Results: Our cumulative analysis did not show any significant difference in terms of BCR, ACM or PCSM rates between the RP and BT cohorts. Only three studies reported risk-stratified outcomes of intermediate- and high-risk patients, which are the most prone to treatment failure. Conclusions: our analysis suggested that RP and BT may have similar oncologic outcomes. However, the analysis included a limited number of studies, and most of them were retrospective, making it impossible to derive any definitive conclusion, especially for intermediate- and high-risk patients. In this scenario, appropriate urologic counseling remains of utmost importance.
Viewpoints of Parents and Nurses on How to Design Products to Enhance Parent–Infant Bonding at Neonatal Intensive Care Units: A Qualitative Study Based on Existing Designs
Authors: Schrauwen Laura , Kommers Deedee R. , Oetomo Sidarto Bambang 
Published: October 2017

Aim: To investigate how product design can be used to improve parent–infant bonding in a neonatal intensive care unit. Background: Impaired parent–infant bonding is an inevitable consequence of premature birth, which negatively influences development. Products, systems, or services that support the bonding process might counter these negative influences. Method: The first step was to trace existing products by performing a literature search in PubMed, the university library, and Google. The identified existing designs were then used in semistructured interviews with nurses and parents to get insights into their desires and recommendations for product design to enhance bonding. Interviews contained open questions and a multiple-choice questionnaire based on the literature search. Results: In total, 17 existing design types were used in interviews with 11 parents and 23 nurses. All nurses explicitly stated that practicality was the first criterion designs aimed at enhancing bonding definitely had to meet. All parents indicated that they would like to use a design to enhance bonding if that would contribute to their child’s health and development. For both parents and nurses, the most valuable way to enhance bonding seemed to be products to improve Kangaroo care; however, their specific desires varied substantially. Therefore, seven recurring themes were defined, resulting in nine general recommendations and six opportunities intended to enhance parent–infant bonding. Conclusion: This study provides design recommendations and opportunities based on parents’ and nurses’ expert opinions. Designing to enhance bonding is considered valuable; however, designs should match the stakeholders’ desires and conditions.