bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal cognitive trajectories and associated clinical variables in youth with bipolar disorder
Authors: Frías Álvaro , Dickstein Daniel P , Merranko John , Gill Mary Kay , Goldstein Tina R , Goldstein Benjamin I , Hower Heather , Yen Shirley , Hafeman Danella M , Liao Fangzi , Diler Rasim , Axelson David , Strober Michael , Hunt Jeffrey I , Ryan Neal D , Keller Martin B , Birmaher Boris 
Published: June 2017

ObjectiveThere is substantial interest in delineating the course of cognitive functioning in bipolar (BP) youth. However, there are no longitudinal studies aimed at defining subgroups ofBPyouth based on their distinctive cognitive trajectories and their associated clinical variables.MethodCognitive functioning was measured in 135 participants from the Course and Outcome ofBPYouth (COBY) study using several subtests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Youth were prospectively evaluated three times on average every 13.75 months over 2.5 years. Clinical and functional outcomes were assessed using the Longitudinal Interval Follow‐Up Evaluation (LIFE).ResultsLatent class growth analysis identified three longitudinal patterns of cognitive functioning based on a general cognitive index: class 1, “persistently high” (N=21; 15.6%); class 2, “persistently moderate” (N=82; 60.74%); and class 3, “persistently low” (N=32; 23.7%). All classes showed normal cognitive functioning when compared with theCANTABnormative data. After adjustment for confounders, youth from class 3 had a significantly greater percentage of time with overall, manic, and depressive syndromal symptoms than youth in the other two classes. Also, after adjustment for confounders, youth from class 3 had significantly poorer global, academic, and social functioning than youth from class 1.ConclusionsBPyouth showed normal overall cognitive functioning that remained stable during the follow‐up within each class. However, 24% ofBPyouth showed poorer cognitive functioning than the otherBPyouth. This subgroup had poorer mood course and functioning, and may benefit from cognitive remediation and early management with evidence‐based pharmacological treatments.
Clinical and treatment‐related features determining the risk of late relapse in patients with diffuse large B‐cell lymphoma
Authors: Modvig Lena , Vase Maja , d‘Amore Francesco 
Published: June 2017

SummaryIt is still unclear whether there are clinically exploitable differences in the biology and behaviour of early versus late relapses in diffuse large B‐cell lymphoma (DLBCL). The present study aimed to analyse a large population‐based DLBCL cohort in order to identify (i) the frequency of late relapses (LR), (ii) parameters influencing the risk of LR, and (iii) the impact of introducing rituximab on the occurrence of LR. The data of 7247 DLBCL patients was obtained from the Danish Lymphoma Group Registry. Patients with LR had a lower International Prognostic Index and better performance score than early relapse (ER) patients. The use of radiotherapy lowered only the rate of ER while the use of rituximab yielded a lower occurrence of both ER and LR (P < 0·0001 and P < 0·0001, respectively), possibly suggesting a longer‐lasting biological effect. Additionally, we found a female overrepresentation among LR patients that had received a rituximab‐containing first line treatment. It was found that patients with LR had a significantly better 5‐year overall survival compared to ER patients. In conclusion, LR was more frequently associated with low‐risk features than ER. Furthermore, we found that the use of modern immunochemotherapy regimens in DLBCL lowers the risk of both ER and LR.
Basin‐axial progradation of a sediment supply driven distributive fluvial system in the Late Cretaceous southern Utah foreland
Authors: Primm Jonathan W. , Johnson Cari L. , Stearns Michael 
Published: June 2017

AbstractThe Turonian‐Coniacian Smoky Hollow Member of the Straight Cliffs Formation in the Kaiparowits basin of southern Utah records a stratigraphic transition from isolated fluvial channel bodies to increasingly amalgamated channel belts capped by the Calico bed, a sheet‐like sand‐gravel unit. Characteristics of the Smoky Hollow Member are consistent with a prograding distributive fluvial system including: up‐section increases in average grain size, bed thickness, channel‐body amalgamation, a fan‐shaped planform morphology and a downstream increase in channel sinuosity. The system prograded to the northeast based on thickness and facies patterns, and palaeocurrent indicators. This basin‐axial sediment‐dispersal trend, which was approximately parallel to the fold‐thrust belt at this latitude, is supported by provenance data including detrital zircons and modal sandstone compositions indicating sediment derivation mainly from the Mogollon Highlands and Cordilleran magmatic arc to the southwest, with episodic input from the more proximal Sevier fold‐thrust belt to the west. Progradation occurred during a eustatic still‐stand, relatively stable climatic conditions, and continuous tectonic subsidence, thus suggesting increased extrabasinal sediment supply as a primary control on basin‐fill. Progradation of the Smoky Hollow Member fluvial system culminated in a ~2–3 My hiatus at the top of the lower Calico bed. Correlation with the Notom delta of the Ferron Sandstone, 80 km northeast in the Henry basin, is proposed on the basis of facies relationships and geochronology. The Calico bed unconformity is linked to regional tectonically driven tilting and erosion observed in both basins.
Periodontitis and breast cancer: A case‐control study
Authors: Sfreddo Camila S. , Maier Juliana , De David Silvia C. , Susin Cristiano , Moreira Carlos Heitor C. 
Published: June 2017

AbstractObjectivesThe aim of this case‐control study was to evaluate the association between periodontitis and breast cancer in a sample of adult Brazilian women.MethodsThis was a hospital‐based study, which included 67 cases and 134 controls (1:2). Women were selected consecutively between April, 2013 and June, 2015 among those attending the Department of Gynecology at the University Hospital of Santa Maria. Cases were selected among women diagnosed with breast cancer (ICD‐10 C50), and controls were matched for age (±2 years), and smoking status (never, former and current smoker). Conditional logistic regression was used to model the association between periodontitis and breast cancer with and without adjustment for potential confounders. Four case definitions for periodontitis were used.ResultsCases had significantly greater clinical attachment loss than controls (P=.04). After adjusting for important covariates, women diagnosed with periodontitis had two to three times higher odds of breast cancer than women without periodontitis depending on the case definition of periodontitis (P<.05).ConclusionsA significant association was observed between periodontitis and breast cancer.
Method and Excel VBA Algorithm for Modeling Master Recession Curve Using Trigonometry Approach
Authors: Posavec Kristijan , Giacopetti Marco , Materazzi Marco , Birk Steffen 
Published: June 2017

AbstractA new method was developed and implemented into an Excel Visual Basic for Applications (VBAs) algorithm utilizing trigonometry laws in an innovative way to overlap recession segments of time series and create master recession curves (MRCs). Based on a trigonometry approach, the algorithm horizontally translates succeeding recession segments of time series, placing their vertex, that is, the highest recorded value of each recession segment, directly onto the appropriate connection line defined by measurement points of a preceding recession segment. The new method and algorithm continues the development of methods and algorithms for the generation of MRC, where the first published method was based on a multiple linear/nonlinear regression model approach (Posavec et al. 2006). The newly developed trigonometry‐based method was tested on real case study examples and compared with the previously published multiple linear/nonlinear regression model‐based method. The results show that in some cases, that is, for some time series, the trigonometry‐based method creates narrower overlaps of the recession segments, resulting in higher coefficients of determination R2, while in other cases the multiple linear/nonlinear regression model‐based method remains superior. The Excel VBA algorithm for modeling MRC using the trigonometry approach is implemented into a spreadsheet tool (MRCTools v3.0 written by and available from Kristijan Posavec, Zagreb, Croatia) containing the previously published VBA algorithms for MRC generation and separation. All algorithms within the MRCTools v3.0 are open access and available free of charge, supporting the idea of running science on available, open, and free of charge software.
Water contents of clinopyroxenes from sub‐arc mantle peridotites
Authors: Turner Michael , Turner Simon , Blatter Dawnika , Maury Rene , Perfit Michael , Yogodzinski Gene 
Published: June 2017

AbstractOne poorly constrained reservoir of the Earth's water budget is that of clinopyroxene in metasomatised, mantle peridotites. This study presents reconnaissance Sensitive High‐Resolution, Ion Microprobe–Stable Isotope (SHRIMP–SI) determinations of the H2O contents of (dominantly) clinopyroxenes in rare mantle xenoliths from four different subduction zones, i.e. Mexico, Kamchatka, Philippines, and New Britain (Tabar‐Feni island chain) as well as one intra‐plate setting (western Victoria). All of the sub‐arc xenoliths have been metasomatised and carry strong arc trace element signatures. Average measured H2O contents of the pyroxenes range from 70 ppm to 510 ppm whereas calculated bulk H2O contents range from 88 ppm to 3 737 ppm if the variable presence of amphibole is taken into account. In contrast, the intra‐plate, continental mantle xenolith from western Victoria has higher water contents (3 447 ppm) but was metasomatised by alkali and/or carbonatitic melts and does not carry a subduction‐related signature. Material similar to the sub‐arc peridotites can either be accreted to the base of the lithosphere or potentially be transported by convection deeper into the mantle where it will lose water due to amphibole breakdown.
¿Qué competencias protegen a los titulados en caso de atonía del mercado laboral?
Authors: HUMBURG Martin , de GRIP Andries , van der VELDEN Rolf 
Published: June 2017

ResumenSe explora la relación entre competencias y riesgo de sobrecalificación y desempleo en titulados universitarios de 17 países europeos. Distinguiendo entre competencias especializadas y académicas, se observa que, como predice la hipótesis de exclusión, las primeras ofrecen mayor protección frente al riesgo de sobrecalificación cuando aumenta el excedente de trabajadores en el ámbito ocupacional de la especialidad del titulado, y las segundas, cuando aumenta ese excedente en el mercado laboral general. Asimismo, las competencias especializadas protegen contra el riesgo de desempleo, pero este no correlaciona con el nivel de competencias académicas según nuestros resultados.
Contextualizing a professional social network for health care: Experiences from an action design research study
Authors: Mettler Tobias 
Published: June 2017

AbstractProfessional social networks (PSN) are online environments where practitioners can present themselves, get in contact and socialize with coworkers, share and discuss ideas, or exchange business‐related knowledge. Despite the fact that collaboration and information sharing are becoming more relevant for delivering high‐quality services, PSN are not yet widely adopted in complex domains such as health care. While most of the literature is still focusing on the exposition of the unbound potential of PSN, this paper seeks to clarify the question of how to capture and manage the professional identity of an industry such that PSN can be purposefully anchored in the working context. Following an Action Design Research approach, we describe practical design propositions and possible tensions along the contextualization of a PSN, which was specifically catered for improving interprofessional and interorganizational collaboration in and between hospitals. We identify several implications for future research. In particular, we explain intended and unintended uses of PSN in hospitals and provide metaphors for explaining possible alternative understandings of domain engineering.
Anesthetic ointment only (lidocaine/prilocaine) instead of injectable local lidocaine in trans‐radial catheterization: A viable no‐needle alternative
Authors: Latsios George , Toutouzas Kostas , Antonopoulos Alexios S. , Melidi Eleni , Synetos Andreas , Vogiatzi Georgia , Stasinopoulou Aggeliki , Tsioufis Kostas , Tsiamis Eleftherios , Tousoulis Dimitrios 
Published: June 2017

ObjectiveThe aim of the present study was to assess the level of access site pain in patients undergoing transradial coronary catheterization by using topical application of an anesthetic ointment (lidocaine/prilocaine—AO) compared to standard local anesthesia (LA) by means of injectable lidocaine.MethodsWe prospectively studied 444 patients undergoing elective trans‐radial coronary angiography. The quality of analgesia was assessed using a visual analogue scale (VAS) immediately after the puncture and 30 min after the removal of the sheath. The number and duration of attempts before successful sheath insertion, as well as artery spasm, were compared between the two groups.ResultsPain levels measured by VAS were found to be similar between the two groups during sheath insertion (VAS: AO: 4.84 ± 1.0 vs 4.82 ± 1.2, P = NS), as well as 30 min after sheath removal (VAS: AO: 0.07 ± 0.5 vs LA: 0.15 ± 0.6, P = NS). The time to obtain radial access was also not affected by the use of anesthetic ointment (AO: 62.24 ± 25.7 s vs LA: 64.04 ± 18.78 sec, P = NS). The rate of clinical or angiographic radial artery spasm was similar (8‐10%) between the groups (P = NS)ConclusionUse of a local anesthetic ointment, versus injectable lidocaine, in trans‐radial cardiac catheterization as means of local anesthesia, was found to be equally effective in terms of pain, artery spasm, or artery cannulation speed.
Hydrometeorology organizes intra‐annual patterns of tree growth across time, space and species in a montane watershed
Authors: Martin Justin , Looker Nathaniel , Hoylman Zachary , Jencso Kelsey , Hu Jia 
Published: June 2017

Summary

Tree radial growth is often systematically limited by water availability, as is evident in tree ring records. However, the physiological nature of observed tree growth limitation is often uncertain outside of the laboratory.

To further explore the physiology of water limitation, we observed intra‐annual growth rates of four conifer species using point dendrometers and microcores, and coupled these data to observations of water potential, soil moisture, and vapor pressure deficit over 2 yr in the Northern Rocky Mountains, USA.

The onset of growth limitation in four species was well explained by a critical balance between soil moisture supply and atmospheric demand representing relatively mesic conditions, despite the timing of this threshold response varying by up to 2 months across topographic and elevation gradients, growing locations, and study years.

Our findings suggest that critical water deficits impeding tissue growth occurred at relatively high water potential values, often occurring when hydrometeorological conditions were relatively wet during the growing season (e.g. in early spring in some cases). This suggests that species‐specific differences in water use strategies may not necessarily affect tree growth, and that tissue growth may be more directly linked to environmental moisture conditions than might otherwise be expected.
Eltrombopag for secondary failure of platelet recovery post‐allogeneic hematopoietic stem cell transplant in children
Authors: Ali Salah , Gassas Adam , Kirby‐Allen Melanie , Krueger Joerg , Ali Muhammad , Schechter Tal 
Published: June 2017

AbstractSecondary failure of platelet engraftment occurs in 20% of patients undergoing allogeneic HSCT and is associated with poor outcome. Currently, there are no guidelines for treatment of late thrombocytopenia and platelet transfusion is the mainstay of treatment. Here, we describe the use of Eltrombopag to treat secondary failure of platelet recovery following HSCT in a child with severe aplastic anemia. Eltrombopag resulted in recovery of platelet count with no need for platelet transfusion support with no reported side effects. Eltrombopag may be used successfully in children with secondary failure of platelet recovery post‐HSCT for SAA.
Lung function in relation to farm dwelling and farming activities in rural dwelling children
Authors: Balakrishnan Lakshmi , Rennie Donna , Dosman James , Pahwa Punam , Karunanayake Chandima , Hagel Louise , Lawson Joshua 
Published: June 2017

ABSTRACT
Background and objectiveThe relationship between farming exposures and pulmonary function in a rural paediatric population was evaluated.MethodsBaseline data collection records of the Saskatchewan Rural Health Study (SRHS), a population‐based study, were used. A subset of children (6–14 years old) participated in clinical testing, including anthropometric measures and pulmonary function testing (PFT), using spirometry (n = 584). PFTs followed ATS criteria and all statistical analyses were controlled for age, sex and height.ResultsAmong clinical testing participants, 47.5% were females and 54.5% were farm dwelling. Of those living on farms, 77.5% were livestock farms. Mean percent predicted value (PPV) for forced expiratory volume in 1 s (FEV1
) and forced vital capacity (FVC) among children living on a farm were 104.8% and 105.4%, respectively. Mean PPV for FEV1
and FVC among children not living on a farm were 102.7% and 101.4%, respectively. After adjustment, higher FEV1
(=0.079, SE = 0.033, P = 0.03) and FVC (=0.110, SE = 0.039, P = 0.006) were seen among children living on a farm. A trend towards lower FEV1
/FVC ratio (−0.013, SE = 0.008, P = 0.09) among children living on a farm was seen compared with children not living on a farm. Higher FVC and lower FEV1
/FVC ratio were seen in children who regularly emptied grain bins (P < 0.05). Trends towards higher FEV1
(P = 0.14) and FVC (P = 0.08) were also seen with children living on a farm in the first year of life. Since the majority of the population was Caucasian (91%), the results were not race‐corrected.ConclusionWe addressed the lack of knowledge regarding the association between lung function and rural exposures, and found that differences in lung function were seen between children living on a farm and not living on a farm in rural areas and certain farming activities, specifically emptying grain bins, where lung function was generally better in those living on a farm.
Towards sociology from the arts: An epistemological turn
Authors: Serrão Pedro 
Published: June 2017

AbstractOver the past two decades, Howard Becker's Art Worlds and Pierre Bourdieu's The Rules of Art were guidelines for the dominant paradigms in sociology of art. Nevertheless, according to Bourdieu, sociology and art do not make a good match. To overcome this dilemma, the French sociologist Nathalie Heinich proposed a “sociology from art,” based on the uniqueness of artists and their works, but she neglected artworks as sociological subject. A realistic and persistent criticism against sociology from the arts claims that artworks are fictions created by artists, therefore epistemologically unacceptable as social realities. Is it possible the making of sociology from artworks? Through theoretical review and using the example of literature, I will argue in this paper that artworks are important heuristic resources and a legitimate subject of sociological research.
Collaborative study to establish World Health Organization international reference reagents for dengue virus Types 1 to 4 RNA for use in nucleic acid testing
Authors: Añez Germán , Volkova Evgeniya , Jiang Zhen , Heisey Daniel A. R. , Chancey Caren , Fares Rafaelle C.G. , Rios Maria ,   the Collaborative Study Group
Published: June 2017

BACKGROUNDDengue is the most important reemerging mosquito‐borne viral disease worldwide. Caused by dengue virus (DENV), a member of the genus Flavivirus in the Flaviviridae family, dengue can be asymptomatic (approx. 80% of cases) or symptomatic, ranging from a flu‐like illness known as dengue fever, to a life‐threatening form called severe dengue. DENV is primarily transmitted from human to human through the bite of mosquitoes of the genus Aedes; however, it is also transmissible by transfusion of blood and blood components and by solid organ transplant. Nucleic acid test (NAT) assays are considered the most appropriate approach for blood donor screening for recent DENV infections, but there is no Food and Drug Administration–approved assay for the screening of blood for DENV.STUDY DESIGN AND METHODSAn international collaborative study was conducted to assess the suitability of reference reagent (RR) candidates for DENV Types 1 to 4 RNA for use in NAT‐based assays.RESULTSTwo sets of RR candidates were prepared for each DENV type, one liquid frozen (Set 1) and one lyophilized (Set 2). A total of 28 laboratories from 20 countries agreed to participate in the study, of which 21 submitted the results for qualitative and/or quantitative assessments.CONCLUSIONThe World Health Organization has established the lyophilized materials as international RRs for DENV RNA with a unitage of 13,500, 69,200, 23,400, and 33,900 units/mL for DENV‐1 to ‐4, respectively.
Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation
Authors: He Chenxi , Zhou Yilong , Liu Feng , Liu Haipeng , Tan Hao , Jin Shouguang , Wu Weihui , Ge Baoxue 
Published: June 2017

ABSTRACT

Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the
Pseudomonas aeruginosa
isolates. Although it is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleoside 3′,5′-cyclic monophosphates (cNMPs) to mediate endothelial Tau phosphorylation and permeability, its functional role in the innate immune response is still poorly understood. Transforming growth factor β-activated kinase 1 (TAK1) is critical for mediating Toll-like receptor (TLR) signaling and subsequent activation of NF-κB and AP-1, which are transcriptional activators of innate immunity. Here, we report that ExoY inhibits proinflammatory cytokine production through suppressing the activation of TAK1 as well as downstream NF-κB and mitogen-activated protein (MAP) kinases. Mice infected with ExoY-deficient
P. aeruginosa
had higher levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6), more neutrophil recruitment, and a lower bacterial load in lung tissue than mice infected with wild-type
P. aeruginosa
. Taken together, our findings identify a previously unknown mechanism by which
P. aeruginosa
ExoY inhibits the host innate immune response.