bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Comparison of Enfamil and Similac Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants
Authors: Monga Ranjan , Sampath Venkatesh , Ehrhart Barb , Kumar Navin 
Published: June 2017

Objective To compare growth and metabolic outcomes of premature infants receiving either Enfamil liquid human milk fortifier (ELHMF) or Similac liquid human milk fortifier (SLHMF).
Study Design Infants born at ≤31 weeks' gestational age (GA) with birth weights <1,500 g and exclusively fed on human milk (mother's milk and/or donor milk) were prospectively assigned alternatively to one of the two liquid human milk fortifier (LHMF) groups. Baseline demographic, growth, enteral nutrition, and laboratory data were compared after fortification.
Results In total, 31 preterm infants were recruited (ELHMF = 16; SLHMF = 15) with a mean GA of 27.1 ± 2.1 weeks and birth weight of 993 ± 245 g. The SLHMF group had significantly better weight gain as measured by individual weight z-scores (p = 0.008), better median weight gain velocity (p = 0.014), and less metabolic acidosis (p = 0.016). Overall weight gain was significantly better on mother's own milk in both the fortifier groups. The SLHMF group showed a trend toward higher growth velocity on donor milk compared with ELHMF (p = 0.06). We also observed a higher reticulocyte count (p = 0.003) in the SLHMF group compared with the ELHMF group.
Conclusion In premature infants, between the two liquid human milk fortifiers, ELHMF fortifier is associated with relatively less weight gain and more metabolic acidosis.
Lungenmetastasenchirurgie bei Patienten mit fortgeschrittenen Weichteil- und Osteosarkomen
Authors: Macherey Sascha , Hekmat Khosro , Zarghooni Kourosh , Doerr Fabian , Heldwein Matthias , Wahlers Thorsten 
Published: June 2017

Zusammenfassung
Hintergrund Weichteil- und Osteosarkome sind häufig mit Lungenmetastasen vergesellschaftet. Patienten sind für eine kurative Metastasektomie geeignet, wenn der Primärtumor erfolgreich reseziert worden ist, sie lediglich pulmonale Metastasen aufweisen und die funktionelle Operabilität sowie die vollständige Metastasenresektion gewährleistet sind.
Material und Methoden Systematische Literaturrecherche und qualitative Analyse aller ab dem 01.01.2010 publizierten Fallserien über Patienten nach vollständiger Sarkomresektion und anschließender Lungenmetastasenchirurgie. Zielparameter waren operative Befunde, Überlebensdaten und Prognosefaktoren.
Ergebnisse Die Lungenmetastasenchirurgie ermöglicht ein medianes Postmetastasektomieüberleben von 8,76 bis 69,9 Monaten. Postoperativ werden nach Metastasektomie 5-Jahres-Überlebensraten zwischen 21,7 und 56,8% erreicht, dabei hängt die Prognose maßgeblich von der vollständigen Resektion aller Lungenmetastasen ab. Intrapulmonale Rezidive können nach kritischer Indikationsstellung reseziert werden und mit einer günstigen Prognose verbunden sein.
Schlussfolgerungen Für selektionierte Patienten mit Osteosarkomen und isolierter Lungenmetastasierung sollte die Metastasektomie die Therapie der Wahl sein. Patienten mit Weichteilsarkomen und isolierter pulmonaler Metastasierung können bei richtiger Indikationsstellung von einem chirurgischen Eingriff profitieren.
Exploring diagnostic and therapeutic implications of endoscopic mucosal resection in EUS-staged T2 esophageal adenocarcinoma
Authors: Gotink Annieke , Spaander Manon , Doukas Michael , Tang Thjon , Didden Paul , Wijnhoven Bas , Bruno Marco , Koch Arjun 
Published: June 2017

Abstract
Background and study aims Treatment strategies for clinical (c)T2N0M0 esophageal adenocarcinoma (EAC) are subject to debate owing to the relative inaccuracy of tumor staging by endoscopic ultrasound (EUS), with profound implications in overstaged patients. We aimed to evaluate the final histological diagnosis of patients initially staged as having a cT2 tumor by EUS, and to assess the value of endoscopic reassessment by an interventional endoscopist, followed by an endoscopic resection when deemed feasible.
Patients and methods Two distinct cohorts of patients with cT2 EAC as determined by EUS were included: a retrospective surgical cohort of patients treated by primary esophagectomy, and a prospective cohort of patients who underwent an endoscopic reassessment by an interventional endoscopist. The main outcome measure was the final pathological (p)T stage.
Results We identified 134 patients with stage T2 EAC from the surgical cohort. In 72 patients treated by primary esophagectomy, 32/72 (44 %) were downstaged to a pT1 tumor. In 12/72 (17 %), the surgical resection specimen showed tumor characteristics that fulfilled the current criteria for a curative endoscopic resection. In 13 prospectively identified patients with cT2N0M0 EAC, an expert endoscopic reassessment was done. In 11/13 (85 %) the lesion appeared endoscopically resectable and a complete endoscopic resection was performed. Histology revealed a pT1 tumor in all 11 patients, with 5/13 (38 %) fulfilling current criteria for a curative endoscopic resection.
Conclusions In this study, 44 % of cT2 EACs were in fact pT1 tumors. Curative treatment by endoscopic resection was achieved in more than a third of these cases. To avoid an unnecessary esophagectomy, an endoscopic reassessment by an interventional endoscopist is recommended for all patients with cT2N0M0 EAC.
Efficacy and Limitations of Conservative Treatment for Painful Patella Partita: Positioning of an Ultrasound-Accelerated Fracture Healing Apparatus
Authors: Sugimura Natsuki , Hirose Daisuke , Aso Koji , Izumi Masashi , Okanoue Yusuke , Kitaoka Kazuo , Ikeuchi Masahiko 
Published: June 2017

Objective:
Generally, painful patella partita is conservatively treated, but the usefulness of a low-intensity pulsed ultrasound (LIPUS) healing apparatus is unclear. The objective of this study was to investigate the usefulness of LIPUS for conservative treatment of painful patella partita.

Subjects and Methods:
The subjects included 17 patients diagnosed with painful patella partita. The subjects were divided into 2 groups: those without pain at 6 months (responsive group) and those with pain that persisted for 6 months or longer (non-responsive group). The reasons for the different responses between the 2 groups were investigated. We evaluated various factors, including age, gender, presence or absence of epiphyseal closure on plain xp at the first examination, Saupe classification, presence or absence of bone union, and type of conservative treatment. The grade of limitation of movement, the presence or absence of instruction on quadriceps femoris muscle stretch, and use of an orthosis and LIPUS were also investigated.

Results:
The responsive and non-responsive groups consisted of 12 and 5 patients, respectively, and included only male patients. The average age was 13 and 16 years old in the responsive and non-responsive groups, respectively. Epiphyseal closure was present in 1 of the 12 patients in the responsive group and 3 of the 5 patients in the non-responsive group. The Saupe classifications in the responsive and in the non-responsive groups, respectively, were type I in 1 and 2 patients (3 total), type II in 6 and 1 patients (7 total), and type III in 4 and 3 patients (7 total). Bone union was achieved in 10 patients in the responsive group, whereas no patient achieved bone union and 3 patients underwent excision in the non-responsive group. Conservative treatment in the responsive and non-responsive groups, respectively, included prohibition of exercise for 7 and 2 patients (9 total) and instruction on quadriceps femoris muscle stretch for 5 and 2 patients (7 total). In addition, all of the 8 patients wearing an orthosis and 2 patients treated with LIPUS were in the responsive group.

Discussion:
The findings suggest that painful Saupe type II patella partita can be improved by appropriate conservative treatment before epiphyseal closure. LIPUS may be advantageous for bone union and pain relief.
Study on Ultrasound Irradiation Induction of Electrical Potentials in Bone
Authors: Matsukawa Mami , Matsukawa Sayaka 
Published: June 2017

Objective:
It is well known that applied stress induces electrical potentials in bone. We have experimentally studied whether induced potentials could be found in bone using an ultrasound irradiation system similar to low-intensity pulsed ultrasound (LIPUS).

Materials and Methods:
Circular plate specimens (diameter 10 mm, thickness 1 mm) were obtained from bovine femora in order to determine if bone behaved as a piezoelectric material. Using these specimens, ultrasound receivers were fabricated. The irradiation of an ultrasound pulsed wave (amplitude 5 kPa, around 1 MHz) induced weak electrical potentials that were almost 0.1% of that observed with conventional ultrasonic transducers using piezoelectric polymer films.

Results and Discussion:
The induced potentials clearly depended on the angle between the direction of the irradiation and the direction of the bone axis and showed a maximum when the angle was 45 degrees. It is known that the ultrasonic wave velocity changes due to the propagation direction and shows anisotropy. The behavior of induced potentials, however, was different from the anisotropy of wave velocities. These results tell us that the amount of induced electrical potentials possibly changes depending on the direction of the ultrasound wave produced by the LIPUS system.
Epigenetic regulation of genome integrity by a prion-based mechanism
Authors: Byers James S. , Garcia David M. , Jarosz Daniel F. 
Published: June 2017

ABSTRACTEpigenetic mechanisms mediate diverse gene expression programs in growth and development. Yet whether any can permanently alter the genome is unknown. Here we report a protein-based epigenetic element, a prion, formed by the conserved DNA helicase Mph1/FANCM. [MPH1+] provides resistance to DNA damage, a gain-of-function trait that requires helicase activity and interactions with other DNA repair proteins. Strikingly, the intrinsically disordered regions of Mph1 and human FANCM that are required for prion phenotypes do not resemble known prions. [MPH1+] reduces mitotic mutation rates, but promotes meiotic crossovers, driving phenotypic diversification in wild outcrosses. Remarkably, [MPH1+] is induced by stresses in which the prion is beneficial. Thus, [MPH1+] fuels a quasi-Lamarckian form of inheritance that promotes survival of the current generation and diversification of the next.
Architecture and dynamics of overlapped RNA regulatory networks
Authors: Lapointe Christopher P. , Preston Melanie A. , Wilinski Daniel , Saunders Harriet A. J. , Campbell Zachary T. , Wickens Marvin 
Published: June 2017

ABSTRACTA single protein can bind and regulate many mRNAs. Multiple proteins with similar specificities often bind and control overlapping sets of mRNAs. Yet, little is known about the architecture or dynamics of overlapped networks. We focused on three proteins with similar structures and related RNA-binding specificities – Puf3p, Puf4p, and Puf5p ofS. cerevisiae. Using RNA Tagging, we identified a “super-network” comprised of four sub-networks: Puf3p, Puf4p, and Puf5p sub-networks, and one controlled by both Puf4p and Puf5p. The architecture of individual subnetworks, and thus the super-network, are determined by competition among particular PUF proteins to bind mRNAs, their affinities for binding elements, and the abundances of the proteins. The super-network responds dramatically: the remaining network can either expand or contract. These strikingly opposite outcomes are determined by an interplay between the relative abundance of the RNAs and proteins, and their affinities for one another. The diverse interplay between overlapping RNA-protein networks provides versatile opportunities for regulation and evolution.
Investigation of talent, talent management, its policies and its impact on working environment
Authors: Saddozai Sehrish Khan , Hui Peng , Akram Umair , Khan Muhammad Saad , Memon Suhail 
Published: June 2017

Purpose
The purpose of this paper is to explore broader and dynamic features of talent, talent management, its policies and its impact on academic working environment.

Design/methodology/approach
This research was based on qualitative research in the form of unstructured interviews containing open-ended questions. Data were collected from the university management, deans, heads of departments (HoDs), assistant professors, associate professors and lecturers. The research was conducted in the form of interviews and the participants were asked to define talent, talent management (TM) policies, its usefulness and its impact on the working environment within the university. This study was conducted into two parts. In the first part, all deans, HoDs and human resource management (HRM) (stakeholders) were interviewed, and in the second part, all professors, associate professors, assistant professors and lecturers (talents) were interviewed.

Findings
The present study investigated that talent and TM are very important in any academic organization. The impact of HRM on TM is very important, as it defines how an academic organization works to retain its talent and improve working conditions within the organization. In addition, this paper details the barriers that the human resource department faces with regard to TM and vice versa. Further, the authors attempted to ascertain the academic staff’s perspectives, their needs and the difficulties they face within the university.

Originality/value
This research paper shows the difficulties faced by the government institutions in China and Pakistan and how they cope with the current situation of TM within the available resources, polices and the impact of these on the working environment.
A novel approach for estimating the magnetization curve of magnetic fluids
Authors: Szczech Marcin 
Published: June 2017

Purpose
Magnetization is one of the most important parameters of magnetic fluids. The shape of the magnetization curve often determines the application of a fluid in a device. On the basis of the magnetization curve, it is also possible to estimate, for example, the distribution and size of the particles in a magnetic fluid carrier fluid. The aim of this paper is to present a new approach for estimating the magnetization curve.

Design/methodology/approach
The proposed method is an iterative method based on the measurement of magnetic induction on a test stand. To determine the magnetization curve, a numerical simulation of the magnetic field distributions for the preliminary magnetization curve should also be performed. Numerical simulations for modified forms of the magnetization curve are performed until the difference between the results obtained by the measurement and numerical simulation are the smallest.

Findings
This paper presents the results of magnetization curve research for ferrofluids and magnetorheological fluids.

Originality/value
The discussed method shows the possibilities of using numerical simulations of magnetic field distribution to determine the magnetic properties of magnetic fluids. This method may be an alternative for estimating the magnetization curve of the magnetic fluid compared to other methods.
Numerical investigation of MHD nanofluid free convective heat transfer in a porous tilted enclosure
Authors: Sheikholeslami M. 
Published: June 2017

Purpose
The effect of a magnetic field on nanofluid natural convection in a porous annulus is simulated. Control volume-based finite element method (CVFEM) is applied to find the influence of tilted angle and Darcy, Rayleigh and Hartmann numbers on nanofluid hydrothermal behavior. Vorticity stream function formulation is taken into account. Also, Brownian motion effect on nanofluid thermal conductivity is considered. Results reveal that Hartmann number and tilted angle make changes in nanofluid flow style. Nusselt number enhances with augment of Darcy number and buoyancy forces but reduces with rise of tilted angle and Hartmann number.

Design/methodology/approach
The influence of adding CuO nanoparticles in water on the velocity and temperature distribution in an inclined half-annulus was studied considering constant heat flux. CVFEM is applied to the simulation procedure.

Findings
Influences of CuO volume fraction, inclination angle and Rayleigh number on hydrothermal manners are presented.

Originality/value
Results indicate that inclination angle makes changes in flow style. The temperature gradient enhances with rise of buoyancy forces, whereas it reduces with augment of inclination angle.
Hyperparameter tuning for hidden unit conditional random fields
Authors: Yang Eun-Suk , Kim Jong Dae , Park Chan-Young , Song Hye-Jeong , Kim Yu-Seop 
Published: June 2017

Purpose
In this paper, the problem of a nonlinear model – specifically the hidden unit conditional random fields (HUCRFs) model, which has binary stochastic hidden units between the data and the labels – exhibiting unstable performance depending on the hyperparameter under consideration.

Design/methodology/approach
There are three main optimization search methods for hyperparameter tuning: manual search, grid search and random search. This study shows that HUCRFs’ unstable performance depends on the hyperparameter values used and its performance is based on tuning that draws on grid and random searches. All experiments conducted used the n-gram features – specifically, unigram, bigram, and trigram.

Findings
Naturally, selecting a list of hyperparameter values based on a researchers’ experience to find a set in which the best performance is exhibited is better than finding it from a probability distribution. Realistically, however, it is impossible to calculate using the parameters in all combinations. The present research indicates that the random search method has a better performance compared with the grid search method while requiring shorter computation time and a reduced cost.

Originality/value
In this paper, the issues affecting the performance of HUCRF, a nonlinear model with performance that varies depending on the hyperparameters, but performs better than CRF, has been examined.
Influence of key role players on productivity outcomes in the residential building lifecycle
Authors: Mbachu Jasper , Egbelakin Temitope , Rasheed Eziaku Onyeizu , Shahzad Wajiha Mohsin 
Published: June 2017

Purpose
This study aims to answer the ‘what’ and ‘how’ questions about the key role players’ influence on the overall productivity outcomes in the lifecycle of residential buildings procured through the traditional route.

Design/methodology/approach
A mix of exploratory and descriptive research methods was used to obtain feedback from 179 role-players involved in various phases of the residential building lifecycle (RBLC) in New Zealand. Empirical data were analysed using content analysis, multi-attribute method and Friedman’s two-way analysis of variance.

Findings
Results showed that designers, building owners, main contractors and project managers were the greatest influencers of the productivity outcomes in the RBLC. The priority drivers of these key role-players’ influences on the RBLC productivity outcomes comprised poor brief interpretation, inclination to lowest tender, inadequate prior risk analysis and miscommunication of owner’s requirements and preferences to service providers, respectively. By taking proactive steps to redress their productivity inhibiting acts/omissions as identified in this study, the various role-players could contribute to significant improvement of productivity outcomes in the building lifecycle.

Research limitations/implications
It was not possible to interview all participants that made up the representative random samples from each role-player group due largely to workload related excuses. As a result, the findings and the conclusions may not be generalised beyond the study scope. However, the study achieved its purpose, as the main intent was to provide hypothetical constructs that could guide further confirmatory/experimental studies for residential buildings as well as for other building types.

Practical implications
A succinct and easy-to-follow model was developed as implementation pathway for operationalising the key findings of the study in the industry. The model highlights the Owner-Architect-Contractor Influence Triangle (OACIT) as the 20 per cent of the solutions that could deliver 80 per cent of the productivity improvement in the RBLC.

Originality/value
This study re-examines productivity issues not only from a life-cycle perspective but also from the perspectives of the majority of the key role-players. In addition, the OACIT concept offers a novel productivity improvement tool; it stresses that productivity in the traditionally procured building lifecycle could be optimised if the architect could focus greater attention on brief articulation and the issuance and review of design and specification information. Also, the owner should adopt productivity-enhancing procurement and contract strategies and emphasise more on value-addition and less on lowest tender price.
PlGFenhancesTLR‐dependent inflammatory responses in human mononuclear phagocytes
Authors: Newell Laura F. , Holtan Shernan G. , Yates Jane E. , Pereira Leonardo , Tyner Jeffrey W. , Burd Irina , Bagby Grover C. 
Published: June 2017

ProblemLevels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus‐induced morbidity. We hypothesized PlGFmight contribute to an exaggerated inflammatory response to Toll‐like receptor (TLR) activation.Method of studyPrimary human adult and cord bloodCD14+cells were cultured in the presence ofTLRligands and/or PlGF.ResultsPlGFsignificantly enhanced the magnitude and duration ofTNFmessenger RNA and protein production byTLR‐7/8‐activated monocytes, and increased subsequent production ofTNF‐independent inflammatory cytokines. This PlGF/TLReffect involved multiple inflammatory cytokines/chemokines and was seen with the majority ofTLRagonists. PlGFenhanced phosphorylation of IkappaB kinase (IKK) in monocytes stimulated with theTLR‐7/8 agonist R848, andIKKinhibition completely suppressed the PlGFeffect.ConclusionPlGFenhancesTLR‐signaling upstream ofIKKand contributes to an exaggerated pathologic pro‐inflammatory state in response to activation of maternal and fetal mononuclear phagocytes by specificTLRagonists.
Coping With Racism: Moderators of the Discrimination–Adjustment Link Among Mexican‐Origin Adolescents
Authors: Park Irene J. K. , Wang Lijuan , Williams David R. , Alegría Margarita 
Published: June 2017

What strategies help ethnic minority adolescents to cope with racism? The present study addressed this question by testing the role of ethnic identity, social support, and anger expression and suppression as moderators of the discrimination–adjustment link among 269 Mexican‐origin adolescents (Mage = 14.1 years), 12–17 years old from the Midwestern U.S. Results from multilevel moderation analyses indicated that ethnic identity, social support, and anger suppression, respectively, significantly attenuated the relations between discrimination and adjustment problems, whereas outward anger expression exacerbated these relations. Moderation effects differed according to the level of analysis. By identifying effective coping strategies in the discrimination–adjustment link at specific levels of analysis, the present findings can guide future intervention efforts for Latino youth.