bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of Bio-Min toothpaste in the management of white spot lesions: a randomised control trial
Authors: Johal Ama , Keogh Aoife , Bolooki Honieh 
Published: September 2024

Abstract
Background
White spot lesions (WSL) are common side effects of orthodontic treatment with fixed appliances, in which the surface layer of enamel is demineralised. Thus, remineralisation, that is a partial or complete reversal, of these lesions can occur as they affect the surface enamel. Remineralisation with low-dose fluoride, in addition to optimal oral hygiene and diet, has been recommended to manage WSL. The aim of the planned trial is to assess the effectiveness of a fluoride-containing bioactive glass toothpaste (BioMin™) in its ability to remineralise post-orthodontic demineralised WSL.

Methods
A single-centre, double-blind randomised clinical trial to assess intervention with Bio-Min toothpaste on WSL forming on the teeth of young people completing orthodontic treatment.

Discussion
Remineralisation of WSL can vary depending on the individual and the site of the lesion. There is a range of oral fluoride delivery methods which include toothpastes, oral rinses, and gel preparations, which can aid remineralisation of these lesions. Identifying effective methods of remineralisation to manage this common and unsightly complication of fixed appliance therapy can improve the health and aesthetics of dentition.

Trial registration
ISRCTN.com International Standard Randomised Controlled Trials Number (ISRCTN) 14479893. Registered on 14 May 2020
Evaluation of hop tests based on Y-Balance test and FMS test outcomes in volleyball and basketball players to identify those prone to injury: a potential predictor of injury
Authors: Latifi Sepideh , Kafshgar Zeinab , Yousefi Atiye 
Published: September 2024

Abstract
Background
The quest for a reliable and effective method to identify athletes at risk of injury holds the promise of significantly reducing injury rates and improving overall athletic performance. This research delved into the relationship between the Functional Movement Screen (FMS), Y-Balance Test (YBT), and Hop tests (Side hop, Medial triple hop, and Lateral step-down hop), aiming to determine the potential in predicting injuries of hop tests among division 1 volleyball and basketball players.

Methods
This research was conducted with fifty-two participants from the Division 1 league, encompassing both volleyball and basketball players. The study rigorously employed the Functional Movement Screen (FMS), the Y-Balance Test (YBT), and various hop tests (side hop test, medial triple hop test, lateral step-down hop) to measure relevant variables. The data analysis used logistic regression, ensuring a comprehensive approach to the study.

Results
Results showed no significant relationship between FMS and Hop test for predicting injuries, but there was a relationship between ΔY and side hop that shows side hop test can predict injury, but there was no relationship between Lateral step down, Medial triple hop, and ΔY.

Conclusions
Based on our findings, side hop, despite the medial triple hop and lateral step-down test, can be used as a sports injury predictor.
Ensemble Kalman inversion for image guided guide wire navigation in vascular systems
Authors: Hanu Matei , Hesser Jürgen , Kanschat Guido , Moviglia Javier , Schillings Claudia , Stallkamp Jan 
Published: September 2024

AbstractThis paper addresses the challenging task of guide wire navigation in cardiovascular interventions, focusing on the parameter estimation of a guide wire system using Ensemble Kalman Inversion (EKI) with a subsampling technique. The EKI uses an ensemble of particles to estimate the unknown quantities. However, since the data misfit has to be computed for each particle in each iteration, the EKI may become computationally infeasible in the case of high-dimensional data, e.g. high-resolution images. This issue can been addressed by randomised algorithms that utilize only a random subset of the data in each iteration. We introduce and analyse a subsampling technique for the EKI, which is based on a continuous-time representation of stochastic gradient methods and apply it to on the parameter estimation of our guide wire system. Numerical experiments with real data from a simplified test setting demonstrate the potential of the method.
Adverse health effects of exposure to plastic, microplastics and their additives: environmental, legal and policy implications for Israel
Authors: Belmaker Ilana , Anca Evelyn D. , Rubin Lisa P. , Magen-Molho Hadas , Miodovnik Anna , van der Hal Noam 
Published: September 2024

Abstract
Background
Israel is a regional "hotspot" of plastic pollution, with little discussion of potential adverse health effects from exposure to plastic. This review aims to stimulate discussion and drive policy by focusing on these adverse health effects.

Main body
Plastics are synthetic polymers containing additives which can leach from food- and beverage-contact plastic into our food and beverages, and from plastic textiles onto our skin. Plastics persist in the environment for generations, fragmenting into MNPs: Micro (1 micron–5 mm)-Nano (1 nm–1 micron)-Plastic, which contaminate our atmosphere, water, and food chain. MNP can enter the human body through ingestion, inhalation and touch. MNP < 10 microns can cross epithelial barriers in the respiratory and gastrointestinal systems, and fragments < 100 nm can cross intact skin, enabling entry into body tissues. MNP have been found in multiple organs of the human body. Patients with MNP in atheromas of carotid arteries have increased risk of a combined measure of stroke, cardiovascular disease, and death. Toxic additives to plastics include bisphenols, phthalates, and PFAS, endocrine-disrupting chemicals (EDCs) which cause dysregulation of thyroid function, reproduction, and metabolism, including increased risk of obesity, diabetes, endometriosis, cancer, and decreased fertility, sperm count and quality. Fetal exposure to EDCs is associated with increased rates of miscarriages, prematurity and low birth weight. There is likely no safe level of exposure to EDCs, with increasing evidence of trans-generational and epigenetic effects. There are several existing Israeli laws to reduce plastic use and waste. Taxes on single-use plastic (SUP) were recently cancelled. There are many gaps in regulatory standards for food-, beverage- and child- safe plastic. Existing standards are poorly enforced.

Conclusion
Reduction in production and use of plastic, promotion of recycling and reduction of leaching of toxic additives into our food and beverages are essential policy goals. Specific recommendations: Periodic monitoring of MNP in bottled beverages, food, indoor air; Strengthen enforcement of standards for food-, beverage-, and child-safe plastic; Renew tax on SUPs; National ban on SUP at public beaches, nature reserves and parks; Ban products manufactured with MNP; Increase research on sources and health outcomes of exposure to MNP and EDCs.
A case study of the informative value of risk of bias and reporting quality assessments for systematic reviews
Authors: Leenaars Cathalijn H. C. , Stafleu Frans R. , Häger Christine , Bleich André 
Published: September 2024

AbstractWhile undisputedly important, and part of any systematic review (SR) by definition, evaluation of the risk of bias within the included studies is one of the most time-consuming parts of performing an SR. In this paper, we describe a case study comprising an extensive analysis of risk of bias (RoB) and reporting quality (RQ) assessment from a previously published review (CRD42021236047). It included both animal and human studies, and the included studies compared baseline diseased subjects with controls, assessed the effects of investigational treatments, or both. We compared RoB and RQ between the different types of included primary studies. We also assessed the “informative value” of each of the separate elements for meta-researchers, based on the notion that variation in reporting may be more interesting for the meta-researcher than consistently high/low or reported/non-reported scores. In general, reporting of experimental details was low. This resulted in frequent unclear risk-of-bias scores. We observed this both for animal and for human studies and both for disease-control comparisons and investigations of experimental treatments. Plots and explorative chi-square tests showed that reporting was slightly better for human studies of investigational treatments than for the other study types. With the evidence reported as is, risk-of-bias assessments for systematic reviews have low informative value other than repeatedly showing that reporting of experimental details needs to improve in all kinds of in vivo research. Particularly for reviews that do not directly inform treatment decisions, it could be efficient to perform a thorough but partial assessment of the quality of the included studies, either of a random subset of the included publications or of a subset of relatively informative elements, comprising, e.g. ethics evaluation, conflicts of interest statements, study limitations, baseline characteristics, and the unit of analysis. This publication suggests several potential procedures.
Food waste reduction and its environmental consequences: a quasi-experimental study in a campus canteen
Authors: Fatemi Seyedeh Fatemeh , Eini-Zinab Hassan , Anari Fatemeh Manafi , Amirolad Mahdieh , Babaei Zahra , Sobhani Seyyed Reza 
Published: September 2024

Abstract
Background
Food waste is the third-largest contributor to greenhouse gas emissions, which has severe environmental and economic effects. This study presents a two-level intervention to estimate the quantity and environmental consequences of food waste at a campus canteen, offering innovative solutions to reduce food waste and its environmental footprint.

Methodology
This study involved 300 students and consisted of three main stages: initial food waste assessment, environmental and economic impact evaluation, and qualitative exploration of the causes of food waste through interviews with students. The assessment included direct measures and weighing of leftover food, and the environmental and economic impact was calculated. A two-level intervention was implemented for students and staff, and a re-assessment of food waste was conducted to evaluate the intervention’s impact. Statistical analysis was performed using SPSS.

Results
The study monitored 26 meals, finding that the total amount of food waste in the university canteens was (mean = 60.65 g/person), and the intervention reduced food waste by 16.35% per meal (50.73 g/person). Moreover, after the intervention, the amount of food waste costs and total water waste were reduced by 30.14% and 16.66%, respectively. Grey water was reduced significantly by 12.5% (p = 0.033). Interviews with students identified low-quality meals, unpleasant taste, large portions, and a limited menu as the main causes of food waste.

Conclusions
It is possible to tackle food waste effectively with educational intervention, decreasing portion size, and improving the quality and variety of food.
Resistant starch from plantain (Macho Musa paradisiaca L.) and banana (Roatan Musa sapientum L.) varieties crosslinked with epichlorohydrin
Authors: Aparicio-Saguilán Alejandro , Páramo-Calderón Delia E. , Vázquez-León Lucio A. , Aguirre-Cruz Andrés , García-Muñoz Miguel A. , Valera-Zaragoza Mario , Mendoza-Ambrosio Francisco Noé , Ramírez-Hernández Aurelio 
Published: September 2024

AbstractResistant starch from plantain (Macho Musa paradisiaca L.) and banana (Roatan Musa sapientum L.) varieties was chemically modified by crosslinking using epichlorohydrin (EPI). These modified starches were subjected to in vitro digestibility studies using the Englyst method to determine the content of rapidly digestible starch (RDS), slowly digestible starch (SDS) and resistant starch (RS). The thermal stability of these crosslinked starches was evaluated by gelatinization and retrogradation analyses, and their enthalpies were determined using differential scanning calorimetry (DSC). Additionally, their functional properties were evaluated. Chemical modification with EPI significantly increased the RS content in both starch varieties compared to that in native starch. The enthalpy and gelatinization temperature decreased in the EPI-modified starches of both varieties, indicating lower thermal stability during the gelatinization process compared to that of native starch. In general, both varieties of crosslinked plantain starch had lower viscosity (0.43 Pa*s) than did native starch (0.58 Pa*s). The results indicates that this starch crosslinked with EPI constitutes an alternative for use in food for people with health problems such as high cholesterol levels or postprandial insulin concentrations.
Graphical Abstract
Intravascular lithotripsy in coronary arteries: a review of case reports
Authors: Umeh Chukwuemeka A. , Kaur Harpreet , Paknoosh Sean , Ganjian Benjamin , Samreen Isha , Rainee Khabagnote , Cheng Mindy , Rastogi Anisha , Gupta Rahul 
Published: September 2024

AbstractBackgroundCalcified coronary arteries encountered during percutaneous intervention increase the probability of unsuccessful procedures. Heavy calcification of coronary arteries may lead to suboptimal stent expansion. Intravascular lithotripsy (IVL) is a novel method of transmitting sonic waves in pulses, which fractures the calcific plaque in the vessel with minimal soft tissue injury. This study systematically reviews and summarizes the reported clinical scenarios in which IVL was successfully used in coronary lesions.Main textArticles were obtained by searching PubMed and Embase databases for IVL use in coronary arteries. We restricted the search to case reports. Our study included 84 patients from 70 case reports/case series. The mean age was 70.3 years (SD 10) and ranged from 27 to 96 years, and 67% were males. The indications for the angiogram that led to the use of IVL include chest pain (37.7%), non-ST elevated myocardial infarction (27.9%), ST elevated myocardial infarction (13.1%), and previous under-expanded stent (8.2%). The IVL was used in the left anterior descending artery (60.7%), right coronary artery (35.7%), left main disease (23.8%), and left circumflex (9.5%). Coronary IVL was safely and successfully used in different clinical scenarios for heavily calcified coronary lesions, including in-stent restenosis of native coronary arteries, saphenous vein grafts, and under-expanded stents. In addition, IVL was successfully used synergistically with orbital and rotational atherectomy and drug-coated balloon angioplasty in select patients.ConclusionIVL has successfully been used in an expanding array of clinical scenarios.
Comparing the outcome of using high-flow nasal cannula oxygen therapy versus noninvasive ventilation for chronic obstructive pulmonary disease patients with acute hypercapnic respiratory failure
Authors: Mashad Alaa Gamal , Farrag Mohamed , Ali Maryam , Ruby Dina 
Published: September 2024

Abstract
Background
Noninvasive ventilation (NIV) is frequently employed as a treatment option for acute hypercapnic respiratory failure (AHRF) resulting from chronic obstructive pulmonary disease (COPD). Limited research has substantiated the claims made in recent studies regarding the feasibility of employing high flow nasal cannula (HFNC).

Aim
Our study assessed the outcome of using HFNC versus NIV for COPD patients with AHRF.

Patients and methods
Eighty COPD patients with AHRF were confined to the respiratory intensive care unit (RICU) at Ain-Shams University Hospitals from December 2021 to 2023 and subdivided into two groups (40/group), where the first group was placed on NIV while the second group was placed on HFNC. Data during their hospital stay as demographic data, vital data, arterial blood gases, device duration, treatment failure, and mortality were recorded.

Results
The majority were males with mean age 63.75 ± 9.05 years along with treatment failure and complications 25%, 12.5.% in NIV versus 45%, and zero% in HFNC, respectively, with longer hospital stay in NIV 10–15 days to 7–10 days in HFNC, and with no difference in mortality rate in both groups.

Conclusion
Both modalities NIV and HFNC were effective for treating COPD with AHRF. However, NIV group was significantly superior than HFNC along with apparently faster improvement in ventilatory and respiratory status especially in high CO2 level while less complications and duration of hospital stay in HFNC with no difference in mortality in both groups.
A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2
Authors: Young Caryl A. , Burt Emily , Munnamalai Vidhya 
Published: September 2024

ABSTRACT
During embryonic development, Wnt signaling influences both proliferation and sensory formation in the cochlea. How this dual nature of Wnt signaling is coordinated is unknown. In this study, we define a novel role for a Wnt-regulated gene, Mybl2, which was already known to be important for proliferation, in determining the size and patterning of the sensory epithelium in the murine cochlea. Using a quantitative spatial analysis approach and analyzing Mybl2 loss-of-function, we show that Mybl2 promoted proliferation in the inner sulcus domain but limited the size of the sensory domain by influencing their adjoining boundary position via Jag1 regulation during development. Mybl2 loss-of-function simultaneously decreased proliferation in the inner sulcus and increased the size of the sensory domain, resulting in a wider sensory epithelium with ectopic inner hair cell formation during late embryonic stages. These data suggest that progenitor cells in the inner sulcus determine boundary formation and pattern the sensory epithelium via MYBL2.
Association between surgeon training grade and the risk of revision following unicompartmental knee replacement: An analysis of National Joint Registry data
Authors: Fowler Timothy J. , Howells Nicholas R. , Blom Ashley W. , Sayers Adrian , Whitehouse Michael R. 
Published: September 2024

Background
Unicompartmental knee replacements (UKRs) are performed by surgeons at various stages in training with varying levels of supervision, but we do not know if this is a safe practice with comparable outcomes to consultant-performed UKR. The aim of this study was to use registry data for England and Wales to investigate the association between surgeon grade (consultant, or trainee), the senior supervision of trainees (supervised by a scrubbed consultant, or not), and the risk of revision surgery following UKR.

Methods and findings
We conducted an observational study using prospectively collected data from the National Joint Registry for England and Wales (NJR). We included adult patients who underwent primary UKR for osteoarthritis (n = 106,206), recorded in the NJR between 2003 and 2019. Exposures were the grade of the operating surgeon (consultant, or trainee) and whether or not trainees were directly supervised by a consultant during the procedure (referred to as “supervised by a scrubbed consultant”). The primary outcome was all-cause revision surgery. The secondary outcome was the number of procedures revised for the following specific indications: aseptic loosening/lysis, infection, progression of osteoarthritis, unexplained pain, and instability. Flexible parametric survival models were adjusted for patient, operation, and healthcare setting factors.
We included 106,206 UKRs in 91,626 patients, of which 4,382 (4.1%) procedures were performed by a trainee. The unadjusted cumulative probability of failure at 15 years was 17.13% (95% CI [16.44, 17.85]) for consultants, 16.42% (95% CI [14.09, 19.08]) for trainees overall, 15.98% (95% CI [13.36, 19.07]) for trainees supervised by a scrubbed consultant, and 17.32% (95% CI [13.24, 22.50]) for trainees not supervised by a scrubbed consultant. There was no association between surgeon grade and all-cause revision in either crude or adjusted models (adjusted HR = 1.01, 95% CI [0.90, 1.13]; p = 0.88). Trainees achieved comparable all-cause survival to consultants, regardless of the level of scrubbed consultant supervision (supervised: adjusted HR = 0.99, 95% CI [0.87, 1.14]; p = 0.94; unsupervised: adjusted HR = 1.03, 95% CI [0.87, 1.22]; p = 0.74).
Limitations of this study relate to its observational design and include: the potential for nonrandom allocation of cases by consultants to trainees; residual confounding; and the use of the binary variable “surgeon grade,” which does not capture variations in the level of experience between trainees.

Conclusions
This nationwide study of UKRs with over 16 years’ follow up demonstrates that trainees within the current training system in England and Wales achieve comparable all-cause implant survival to consultants. These findings support the current methods by which surgeons in England and Wales are trained to perform UKR.
Key needs, quality performance indicators and outcomes for patients with atrial fibrillation and multimorbidity: The AFFIRMO study
Authors: Leo Donato Giuseppe , Trevisan Caterina , Ravelli Adele , Lobban Trudie C. A. , Lane Deirdre A. ,   on behalf of the AFFIRMO Study investigators
Published: September 2024

Background
Patients with atrial fibrillation (AF) often have concomitant long-term conditions that negatively impact their quality of life and the clinical management they receive. The AFFIRMO study aimed to identify the needs, quality performance indicators (QPIs), and outcomes relevant to patients, caregivers and healthcare professionals (HCPs) to improve the care of patients with AF.

Methods
An on-line survey to collect the key needs, QPIs, and outcomes relevant to patients with AF, their caregivers and HCPs, was distributed between May 2022 and January 2023 in five countries (UK, Italy, Denmark, Romania and Spain). Results from the on-line survey were discussed in a three-round Delphi process with international representatives of patients with AF, caregivers, and HCPs to determine the key needs, QPIs and outcomes for the management of patients with AF and multimorbidity.

Results
659 patients (47.2% males, mean (SD) age 70.9 (10.2) years), 201 caregivers (26.9% males, mean (SD) age: 58.3 (SD 15.2) years), and 445 HCPs (57.8% males, mean (SD) age 47.4 (10.6) years) participated in the survey. An initial list of 27 needs, 9 QPIs, and 17 outcomes were identified. Eight patients, two caregivers, and 11 HCPs participated in the Delphi process. Nineteen (70%) needs, 8 (89%) QPIs, and 13 (76%) outcomes reached “consensus in”, and were included in the final list.

Conclusions
The final key needs, QPIs and outcomes obtained from the Delphi process will inform the AFFIRMO clinical trial, which aims to test the iABC app which incorporates an empowerment toolbox for patients and their caregivers, providing information to improve patient engagement and empowerment to help improve the clinical and self-management of patients with AF in the context of multimorbidity.