bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental toxicity of auranofin in zebrafish embryos
Authors: Gao Xiao‐Yan , Li Kang , Jiang Ling‐Ling , He Ming‐Fang , Pu Cun‐Hai , Kang Dongzhou , Xie Jingjing 
Published: November 2016

AbstractAuranofin (AF) is used in clinic for the treatment of rheumatoid arthritis, repurposing of AF as an anticancer drug has just finished a phase I/II clinical trial, but the developmental toxicity of AF remains obscure. This study focused on its developmental toxicity by using zebrafish embryos. Zebrafish embryos were exposed to different concentrations (1, 2.5, 5, 10 μm) of AF from 2 h post‐fertilization (hpf) to 72 hpf. At 72 hpf, two major developmental defects caused by AF were found, namely severe pericardial edema and hypopigmentation, when embryos were exposed to concentrations higher than 2.5 μm. Biochemical detection of oxidative stress enzyme combined with expressions of a series of genes related to oxidative stress, cardiac, metal stress and pigment formation were subsequently tested. The superoxide dismutase activity was decreased while malondialdehyde content was accumulated by AF treatment. The expression of oxidative stress‐related genes (sod1, gpx1a, gst), pigment‐related genes (mitfb, trp‐1a) and one metal stress‐related gene ctr1 were all decreased by AF exposure. The expressions of cardiac‐related genes (amhc, vmhc) and one metal‐related gene hsp70 were found to be significantly upregulated by AF exposure. These findings indicated the potential developmental toxicity of AF on zebrafish early development. Copyright © 2016 John Wiley & Sons, Ltd.
A method to study the hemodynamics of chicken embryo's aortic arches using optical coherence tomography
Authors: Ko Zhen Yu Gordon , Mehta Kalpesh , Jamil Muhammad , Yap Choon Hwai , Chen Nanguang 
Published: November 2016

Congenital cardiovascular defects are the leading cause of birth defect related death. It has been hypothesized that fluid mechanical forces of embryonic blood flow affect cardiovascular development and play a role in congenital malformations. Studies in small animal embryos can improve our understanding of congenital malformations and can lead to better treatment. We present a feasibility study in which high‐resolution optical coherence tomography (OCT) and computational fluid dynamics (CFD) are combined to provide quantitative analysis of the embryonic flow mechanics and the associated anatomy in a small animal model.
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Sonographic diagnosis of splenogonadal fusion in a 2‐year‐old boy
Authors: Li Xiaoying , Ye Jingjing , Jiang Guoping 
Published: November 2016

ABSTRACTSplenogonadal fusion (SGF) is a rare congenital abnormality. It is typically identified during orchiectomy for a suspected testicular tumor or during orchiopexy. We describe the sonographic findings in a case of SGF that could help with correct diagnosis preoperatively. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:179–182, 2017
Real‐time confocal laser endomicroscopic evaluation of primary liver cancer based on human liver autofluorescence
Authors: Maki Harufumi , Kawaguchi Yoshikuni , Arita Junichi , Akamatsu Nobuhisa , Kaneko Junichi , Sakamoto Yoshihiro , Hasegawa Kiyoshi , Harihara Yasushi , Kokudo Norihiro 
Published: November 2016

BackgroundConfocal laser endomicroscopy (CLE) is available for real‐time microscopic examination. This study aims to evaluate the usefulness of intraoperative CLE examination as a modality to evaluate surgical margins in surgery for primary liver cancer.MethodsA probe‐based CLE system (Cellvizio 100, Mauna Kea Technologies, Paris, France) was used. The subjects comprised seven specimens obtained from six patients with primary liver cancer in November 2015. The probe was manually attached to the surfaces of specimens, and images were collected without external fluorophores. CLE images were compared with hematoxylin and eosin‐stained slides. Fluorescence intensity (FI) values of the CLE images were assessed using luminance‐analyzing software.ResultsCLE examination visualized non‐cancerous regions in the background liver as regular structures with high fluorescence because of human liver autofluorescence. Conversely, hepatocellular carcinoma and intrahepatic cholangiocarcinoma were depicted as irregular structures with low fluorescence. The median FI values of the non‐cancerous regions and the cancerous regions were 104 (79.8–156) and 74.9 (60.6–106), respectively, and were significantly different (P = 0.031).ConclusionsThe probe‐based CLE enables real‐time differentiation of cancerous regions from non‐cancerous tissues in surgical specimens because of human liver autofluorescence. CLE can be used to confirm negative surgical margins in the operating room. J. Surg. Oncol. 2017;115:151–157. © 2016 Wiley Periodicals, Inc.
Utilization of pre‐operative imaging for colon cancer: A population‐based study
Authors: McInnes Matthew D.F. , Nanji Sulaiman , Mackillop William J. , Flemming Jennifer A. , Wei Xuejiao , Macdonald D. Blair , Scheida Nicola , Booth Christopher M. 
Published: November 2016

ObjectiveTo assess the use of pre‐operative imaging for colon cancer and to identify factors associated with utilization in routine clinical practice.MethodsThis population‐based, retrospective cohort study used a random sample of 25% of colon cancer patients treated with surgery in the province of Ontario (2002–2008). Pre‐operative imaging (<16 weeks from surgery) of the chest, abdomen‐pelvis was identified. Modified poisson regression was used to analyze factors associated with practice patterns.ResultsOf the 7,249 included patients, 48% had pre‐operative imaging (CT abdomen and imaging of the chest) in keeping with guideline recommendations. The rate of guideline concordant pre‐operative imaging increased over time: 64% in the most recent study period (2006–2008) versus 31% (2002–2004); P < 0.001. Variables associated with use of chest imaging: Age, co‐morbidity, surgeon volume, and geographic region; no association with gender, hospital volume, or socio‐economic status. Variables associated with use of abdomen imaging: Hospital volume and geographic region; no association with age, gender, comorbidity, socio‐economic status, or surgeon volume.ConclusionIn clinical practice, the majority of patients were not receiving pre‐operative imaging that was in line with clinical practice guidelines; however, use increased over time indicating a possible association with dissemination of clinical practice guidelines. J. Surg. Oncol. 2017;115:202–207. © 2016 Wiley Periodicals, Inc.
Comparing population growth rates between census and recruitment‐mortality models
Authors: Serrouya Robert , Gilbert Sophie , McNay R. Scott , Mclellan Bruce N. , Heard Douglas C. , Seip Dale R. , Boutin Stan 
Published: November 2016

ABSTRACTIn forested ecosystems, estimating the abundance or trend of most wildlife populations is difficult. Therefore, vital rates are often used to model population change, but validating such models is important. Using data from woodland caribou (Rangifer tarandus), we compared estimates of population change (λ) based on vital rate models to λ based on aerial censuses. We modeled λ using Hatter and Bergerud's (1991) recruitment‐mortality (R‐M) equation (λ = survival/[1 − recruitment]). We estimated survival and recruitment from a sample of 317 radio‐collared caribou from 9 subpopulations in British Columbia, Canada. In this ecosystem, woodland caribou have high sightability (>85%) in winter and thus are easy to census compared to most forest wildlife. We found that the R‐M equation overestimated λ compared to census‐based λ across most of the observed range of data (e.g., if R‐M estimated λ of 1.1, census‐based λ was 0.99, and if R‐M was 0.90, census‐based λ was 0.89). We then assessed whether recruitment, survival, a linear model of both parameters, or the R‐M equation best predicted census‐based λ. The R‐M equation explained 60% of the variation in census‐based λ, more than double the next‐best approach (i.e., the simple linear model), even though identical parameters were included. Further, we simulated variability due to the unknown sex (M:F) ratio in the sample, and found that the R‐M equation remained the best predictor of census‐based λ. Although the R‐M equation was the most precise and accurate approach, our results reaffirm that it is important to periodically validate trend estimates based on vital rate models with estimates of absolute abundance, particularly for species of management concern. © 2016 The Wildlife Society.
Avoiding the scale sampling problem: A consilient solution
Authors: Bissonette J. A. 
Published: November 2016

ABSTRACTWhat if there was a way to solve one of the most complex and important scale challenges that ecologists face: the selection of the appropriate sampling scale resolution and extent when conducting studies. To date, the investigator conducting any study has been tasked with this challenge. Qualitatively different patterns arise as the scale resolution or extent of the observation is changed. Likewise, different patterns arise as the scales of the sampling are changed. Too often, data at one resolution are aggregated or interpretations of patterns at smaller scale resolutions and extents are extrapolated to larger extents. When this is done, either modifiable areal unit problems or extrapolation errors arise. I argue that consilient developments in movement ecology, graph (network) theory and analyses, and important technical advances in biologging can be linked synergistically to directly address the sampling scale problem, particularly in studies where understanding animal response to changing landscapes is the goal. The essence of the solution is that rather than having to decide the spatial extent and resolution to use, the issue is avoided by allowing the telemetered animal to show the relevant scales it uses as it moves during its daily, seasonal, and annual activities. The consilient result is that big data at the appropriate scales can be extracted rather than aggregated as is now the rule. Without data aggregation, no modifiable areal unit problems are involved because the dynamics are network based. Additionally, use of first passage time methodology and measurement of area‐restricted movements allow assessments of the scales of activity and the effects of environmental covariates on animal movement. I begin with a brief history of the concept of scale, describing what is considered to be the essence of the problem. I follow with a brief explanation of the developments in movement ecology, graph theory and analysis, and the technical advancements in biologging with examples from studies of wildlife species that are using these new developments. I then describe how their consilient integration can provide a different way of thinking about scale resolution and extent in ecology and suggest how ecologists can avoid the observer sampling scale complication by making a critical scale distinction and by using first passage time analyses. © 2016 The Wildlife Society.
Soil Biology Changes as a Consequence of Organic Amendments Subjected to a Severe Drought
Authors: Franco‐Andreu Luis , Gómez Isidoro , Parrado Juan , García Carlos , Hernández Teresa , Tejada Manuel 
Published: November 2016

AbstractEffect of severe drought events in combination with organic amendments (municipal solid waste, MSW, sheep manure, SM, and cow manure, CM) on soil dehydrogenase, urease, β‐glucosidase and phosphatase activities and microbial community by analyzing phospholipid fatty acids was studied under controlled laboratory conditions for one year. Two levels of irrigation were used: (1) watered soils, where the soils were maintained at 60% of their water holding capacity through the experiment, and (2) non‐watered soils, without irrigation through the experiment. The severe drought conditions negatively affected the soil enzymatic activities and total bacterial and fungal PLFA concentrations. The application of organic amendments to the soil subjected to severe drought increased soil water retention and encouraged the growth and activity of soil microbial populations. However, the chemical composition of the organic matter applied to the soil also strongly influenced soil moisture. In non‐watered soils and compared with the unamended soil, the dehydrogenase activity was 71 · 3%, 60 · 9% and 38 · 6% higher in the soil with SM, CM and MSW, respectively. Urease activity was 60 · 6%, 51 · 5% and 37% higher in the soil with SM, CM and MSW, respectively. β‐glucosidase and phosphatase activities had a similar trend. Water retention was higher when the organic wastes applied to the soils had a higher content of humic acids than fulvic acid contents. Copyright © 2016 John Wiley & Sons, Ltd.
Cross‐cultural adaptation of the international consultation incontinence questionnaire male lower urinary tract symptoms—long form (ICIQ‐MLUTS‐LF) in Persian
Authors: Pourmomeny Abbas Ali , Mazdak Hamid 
Published: November 2016

AimsThe purpose of this study was to translate male lower urinary tract symptoms long form (MLUTS‐LF) questionnaire and determine its psychometric properties in Persian speaking subjects.IntroductionAssessment instrument is essential for research, making diagnosis, and for evaluating the treatment outcomes in subjects with lower urinary tract disorders of either gender. Long form of MLUTS questionnaire is a robust self‐report questionnaire that investigates the major aspects of lower urinary tract symptoms and their impact on quality of life.MethodsAfter getting permission from the International Consultation International Questionnaire website, the forward and backward translation MLUTS carried out by researcher team and assess content/face/construct validity, reliability in sample of MLUTS Iranian patients and, quality rating and pilot testing.ResultsThe irritating and obstructing lower urinary disorders were categorized as mild, moderate, and severe in the study sample. Twenty two subjects were suffering from urinary incontinence and most of the participants had benign prostate hyperplasia (BPH). Cronbach's alpha coefficient was 0.819. Correlations between the MLUTS and International prostate symptom score (IPSS) was 0.753.DiscussionThe MLUTS Questionnaire showed good internal consistency, content validity, and construct validity, as measured by correlation with scores on the IPSS.ConclusionThe Iranian version of the MLUTS questionnaire is a valid and robust instrument that can be used in clinical settings and in research.
Distinct Osteomimetic Response of Androgen‐Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications
Authors: González Álvaro , García de Durango Cira , Alonso Verónica , Bravo Beatriz , Rodríguez de Gortázar Arancha , Wells Alan , Forteza Jerónimo , Vidal‐Vanaclocha Fernando 
Published: November 2016

BACKGROUND AND METHODSProstate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers. Because mechanical forces physiologically regulate bone‐remodeling activity in osteocytes, we hypothesized that mechanical action of fluid flow (MAFF) at the cancer microenvironment may similarly foster prostate cancer cell osteomimicry.RESULTSWe showed that in vitro MAFF on androgen‐dependent (LNCap) and androgen‐independent (PC3) prostate cancer cells remarkably increased OPG, VEGF, RunX2, PTH1R, and PTHrP gene expression in both cell lines irrespective of their androgen dependency. MAFF also altered the cytokine secretion pattern of prostate cancer cells, including Ang2, SCF, and TNFα increase with TRAIL decrease in the supernatant of both cell lines; preferential increase of Leptin and PDGF‐BB in LnCap and of VEGF, IL‐8, and G‐CSF in PC3; and exclusive increase of FGFβ, MIF, and PECAM‐1 with HGF decrease in LnCap, and of TGBβ1, HGF, M‐CSF, CXCL1, and CCL7 with NGF decrease in PC3. Murine MLO‐Y4 osteocyte‐conditioned medium (CM) abrogated M‐CSF, G‐CSG, IL‐8, TNFα, and FGFβ secretion‐stimulating activity of mechanical stimulation on PC3 cells, and did the opposite effect on LnCap cells. However, MAFF fostered osteomimetic gene expression response of PC3 cells, but not of LnCap cells, to mechanically stimulated osteocyte‐CM. Moreover, it abrogated TNFα and IL‐8 secretion inhibitory effect of osteocyte‐CM on mechanically stimulated PC3 cells and G‐CSF, TNFα, and FGFβ‐stimulating effect on mechanically stimulated LnCap cells.CONCLUSIONSMAFF activated osteoblast‐like phenotype of prostate cancer cells and altered their responses to osteocyte soluble factors. It also induced osteocyte production of osteomimetic gene expression‐ and cytokine secretion‐stimulating factors for prostate cancer cells, particularly, when they were mechanically stimulated. Importantly, MAFF induced a prometastatic response in androgen‐independent prostate cancer cells, suggesting the interest of mechanical stimulation‐dependent transcription and secretion patterns as diagnostic biomarkers, and as therapeutic targets for the screening of bone‐metastasizing phenotype inhibitors upregulated during prostate cancer cell response to MAFF at the cancer microenvironment. Prostate 77:321–333, 2017. © 2016 Wiley Periodicals, Inc.
A novel consensus algorithm for second‐order multi‐agent systems without velocity measurements
Authors: Zhang Wentao , Liu Yang , Lu Jianquan , Cao Jinde 
Published: November 2016

SummaryIn this paper, a novel consensus protocol for second‐order multi‐agent systems is elegantly designed, and it relaxes the common requirement of the velocity information of the agents. An interesting consensus criterion is explicitly derived in terms of the proposed cooperation law provided that the dynamical equation for each agent is linear. As an extension, the proposed cooperation rule is further extended to a general scenario, where the coupling weights characterizing the relationships among the neighboring agents are time‐varying. Accordingly, two distributed cooperative algorithms (node/edge‐based scheme) are explicitly designed. Moreover, we study the case of network with switching communication setting. It shows that edge‐based law is capable with the time‐varying topology, while the node‐based scheme is not. In addition, the proposed coordination strategies are applied to the tracking problem as well. Finally, these obtained consensus results are well supported in the light of the pendulum models. Copyright © 2016 John Wiley & Sons, Ltd.
Synthesis, Vibrational (IR), Thermal analysis and Quantumchemical Study of a Series of Cyclic Chalcones
Authors: Al‐Ansari Ibrahim Ahmed Z. 
Published: November 2016

AbstractIn this work, the influence of expanding the cyclic ring (adding methylene group) on the properties of three dimethylamino chalcones derivatives (1‐3), is addressed, using a combined experimental (vibrational spectra (IR), Differential scanning calorimetry (DSC) and thermo‐gravimetric analysis (TGA) and theoretical (density functional theory (DFT) and natural bond order (NBO) techniques.
Heck Reactions and Carbonylations of Alkenyl Nonaflates – Synthesis of Tetradehydroamino Acids and α,β‐Unsaturated Carboxylic Acids
Authors: Taszarek Maurice , Reissig Hans‐Ulrich 
Published: November 2016

AbstractIn a brief exploratory study we investigated Heck reactions of several alkenyl nonaflates with a protected dehydroalanine derivative. Whereas simple alkenyl nonaflates provided the expected 1,3‐dienes in good to excellent yields, more complex oxa‐bridged bicyclic substrates gave poorer results. Nevertheless, this approach is of interest for the synthesis of tetradehydroamino acids. Palladium‐catalyzed carbonylations of alkenyl nonaflates employing molybdenum hexacarbonyl as convenient carbon monoxide source leading to esters or to carboxylic acids were also studied. Microwave conditions seem to be superior to purely thermal conditions. With an oxygen‐bridged bicyclic alkenyl nonaflate the expected carboxylic acid was isolated, however, the formation of a tropone derivative as a result of an acid‐promoted fragmentation was also observed.
Exploiting long‐term and short‐term preferences and RFID trajectories in shop recommendation
Authors: Ding Yue , Wang Dong , Li Guoqiang , Sun Daniel , Xin Xin , Qian Shiyou 
Published: November 2016

SummaryShop recommendation in large shopping malls is useful in the mobile internet era. With the maturity of indoor positioning technology, customers' indoor trajectories can be captured by radio frequency identification devices readers, which provides a new way to analyze customers' potential preferences. In this paper, we design three methods for the top‐N shop recommendation problem. The first method is an improved matrix factorization method fusing estimated prior customer preference matrix that is constructed by Session‐based Temporal Graph computing. The second method is a Bayesian personalized ranking method based on the first method. The third method is by tensor decomposition combined with Session‐based Temporal Graph. Besides, we exploit customer history radio frequency identification devices trajectory information to find customers' frequent paths and revise predicted rating values to improve recommendation accuracy. Our methods are effective in modeling customers' temporal dynamics. At the same time, our approach considers repeated recommendation of the same shop by designing rating update rules. The test dataset is formed by JoyCity customer behavior records. JoyCity is a large‐scale modern shopping center in downtown Shanghai, China. The results show that our approaches are effective and outperform previous state‐of‐the‐art approaches. Copyright © 2016 John Wiley & Sons, Ltd.
Zur Entwicklungsgeschichte des Stahlverbundbaus
Authors: Pelke Eberhard , Kurrer Karl‐Eugen 
Published: November 2016

AbstractÜber die historische Entwicklung des Fügens biegesteifer Bauteile der Werkstoffe Stahl und Beton – des Stahlverbundbaus – ist bisher wenig bekannt. Im vorliegenden Aufsatz werden deshalb die einzelnen Phasen so herausgearbeitet, dass die Entwicklungsgeschichte des Stahlverbundbaus in großen Zügen erkennbar wird.Die Initialphase (1850–1900) bildet den Verbundträger im Sinne von Empergers Ideal vom Haftverbund der Werkstoffpartner aus. Sukzessive folgt die konstruktive Trennung der Querschnittsteile in der Konstituierungsphase (1900–1925). In der Etablierungsphase (1925–1945) wächst die Erkenntnis, die Querschnittsteile konstruktiv verbinden zu müssen, zunächst als Lage‐ und dann als mechanische Schubsicherung. Dabei steht der Versuch im Mittelpunkt des Erkenntnisgewinns. Das quantifizierte Verbinden der Querschnittsteile durch ein konsolidiertes Versuchswesen und die Theoriebildung in der Vollendungsphase (1945–1981) lässt eine vielfältig gebaute Wirklichkeit im Industrie‐ und Stahlverbundbrückenbau entstehen.On the evolution of steel‐concrete composite construction. Little has been written so far about the historical development of the joining of rigid elements made from steel and concrete – steel‐concrete composite construction. This article therefore describes the individual phases in such a way that the reader gains an overview of the evolution of composite construction with steel and concrete.The composite beam in the sense of Emperger's ideal of the friction/adhesion bond between the materials marked the initial phase (1850–1900). This was followed by the constitution phase (1900–1925) with its constructional separation of the elements of the cross‐section. During the establishment phase (1925–1945) it was gradually realized that the elements of the cross‐section had to be connected structurally, initially as positional restraint, later as mechanical shear connector. Tests verifies the bearing capacity of steel composite constructions. The quantified connection of the elements of the cross‐section through standardized testing and the formation of theories in the classical phase (1945–1981) enabled the realization of multiple forms of steel‐concrete composite construction for industrial buildings and bridges.