bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation
Authors: Miquel Lea , Testud Benoit , Albarel Frederique , Sahakian Nicolas , Cuny Thomas , Graillon Thomas , Brue Thierry , Dufour Henri , Schleinitz Nicolas , Kaplanski Gilles , Ebbo Mikael , Castinetti Frederic 
Published: September 2024

Abstract

Context
Hypophysitis is defined as an inflammation of the pituitary gland and/or infundibulum.

Objective
Our aim was to characterize the initial course and evolution of patients with hypophysitis according to the different etiologies.

Methods
Retrospective observational study conducted in a university referral hospital center. Patients over 15 years of age were included if they had a diagnosis of hypophysitis between January 2014 and October 2023, with the exclusion of hypophysitis secondary to immune checkpoint inhibitors.

Results
Sixty-one patients (64% women; median age, 34 years) were included. Polyuria–polydipsia, headache, and asthenia were present in 64%, 48%, and 44% of cases respectively. At diagnosis, at least 1 anterior pituitary deficiency was present in 91.5% of cases and vasopressin deficiency in 56%. Magnetic resonance imaging was abnormal in 97% of cases. Secondary hypophysitis was found in 46% of cases (n = 28), including sarcoidosis in 28% (n = 17) and L (Langerhans) group histiocytoses in 13.1% (n = 8). Among patients with secondary hypophysitis, pituitary deficiency preceded systemic manifestations in 23% and occurred concomitantly in 23% of cases. Patients were treated in 36% of cases (glucocorticoids, surgery), without improvement of pituitary hormone deficits.

Conclusion
A systemic etiology of hypophysitis was found in almost half of the patients. Pituitary disorders preceded the systemic disease in a quarter of the cases. This emphasizes the importance of a systematic repeated workup looking for a secondary etiology of hypophysitis in these patients.
Neuregulin 1 Signaling Attenuates Tumor Necrosis Factor α–Induced Female Rat Luteal Cell Death
Authors: Banerjee Saswati , Oguljahan Babayewa , Thompson Winston E , Chowdhury Indrajit 
Published: September 2024

Abstract
The corpus luteum (CL) is a transient ovarian endocrine structure that maintains pregnancy in primates during the first trimester and in rodents during the entire pregnancy by producing steroid hormone progesterone (P4). CL lifespan, growth, and differentiation are tightly regulated by survival and cell death signals through luteotrophic and luteolytic factors, including the epidermal growth factor (EGF)-like factor family. Neuregulin 1 (NRG1), a member of the EGF family, mediates its effect through ErbB2/3 receptors. However, the functional role of NRG1 in luteal cells (LCs) is unknown. Thus, this study investigated the role of NRG1 and its molecular mechanism of action in rat LC. Our experimental results suggest a strong positive correlation between steroidogenic acute regulatory protein (StAR) and NRG1 expression in mid-CL and serum P4 and estrogen (E2) production. In contrast, there was a decrease in StAR and NRG1 expression and P4 and E2 production with an increase in tumor necrosis factor α (TNFα) expression in regressing CL. Further in vitro studies in LCs showed that the knockdown of endogenous Nrg1 promoted the expression of proinflammatory and proapoptotic factors and decreased prosurvival factor expression. Subsequently, treatment with exogenous TNFα under these experimental conditions profoundly elevated proinflammatory and proapoptotic factors. Further analysis demonstrated that the phosphorylation status of ErbB2/3, PI3K, Ak strain transforming or protein kinase B (Akt), and ErK1/2 was significantly inhibited under these experimental conditions, whereas the treatment of TNFα further inhibited the phosphorylation of ErbB2/3, PI3K, Akt, and ErK1/2. Collectively, these studies provide new insights into the NRG1-mediated immunomodulatory and prosurvival role in LCs, which may maintain the function of CL.
Working Status in Patients With Untreated Unruptured Intracranial Aneurysms: A Descriptive Longitudinal Study
Authors: Majewska Paulina , Sandvei Marie Søfteland , Gulati Sasha , Müller Tomm B. , Hara Karen Walseth , Romundstad Pål Richard , Solheim Ole 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Many patients with unruptured intracranial aneurysms (UIAs) remain untreated if the risk of treatment exceeds the estimated risk of aneurysm rupture, potentially leading to diagnosis-related stress and anxiety. Working status may serve as a marker for the total level of function including mental health and psychological burden of the condition. The aim of the study was to assess the working status before and after a diagnosis of an untreated UIA.

METHODS:
This was a retrospective nationwide registry-based descriptive longitudinal study. It included all working-age patients diagnosed with an UIA in Norway between 2008 and 2018 and 1:1 age-matched and sex-matched controls without a diagnosis of an intracranial aneurysm that were randomly selected from the Norwegian population. The history of sickness absence in the period of 1 year before and after diagnosis was retrieved from The Norwegian Labour and Welfare Administration records and compared between the groups.

RESULTS:
In total, 2141 patients and 2141 controls were included in the study. Proportion of working patients decreased from 62.1% (95% CI 60.0%-64.1%) 1 year before the diagnosis to 51.3% (95% CI 49.1%-53.4%) 1 year after the diagnosis (P < .001). In comparison, the proportion of working controls decreased from 77.9% (95% CI 76.1%-79.6%) 1 year before day 0 to 73.4% (95% CI 71.5%-75.2%) 1 year after day 0 (P = .001). The odds of working were 86.7% lower among the patients than among the controls (odds ratio 0.133, 95% CI 0.091-0.194; P < .001) when controlled for the baseline working status. The older the individuals, the less likely they were to work (odds ratio 0.908, 95% CI 0.889-0.926; P < .001).

CONCLUSION:
The work participation of patients diagnosed with UIA is low prediagnosis compared with the general population and decreases significantly postdiagnosis.
Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release
Authors: Min Kyung-Won , Choi Kyoung-Min , Mun Hyejin , Ko Seungbeom , Lee Ji Won , Sagum Cari A. , Bedford Mark T. , Kim Young-Kook , Delaney Joe R. , Cho Jung-Hyun , Dawson Ted M. , Dawson Valina L. , Twal Waleed , Kim Dong-Chan , Panganiban Clarisse H. , Lang Hainan , Zhou Xin , Shin Seula , Hu Jian , Heise Tilman , Kwon Sang-Ho , Kim Dongsan , Kim Young Hwa , Kang Sung-Ung , Kim Kyungmin , Lewis Sydney , Eroglu Ahmet , Ryu Seonghyun , Kim Dongin , Chang Jeong Ho , Jung Junyang , Yoon Je-Hyun 
Published: September 2024

ABSTRACT
Argonaute (AGO), a component of RNA-induced silencing complexes (RISCs), is a representative RNA-binding protein (RBP) known to bind with mature microRNAs (miRNAs) and is directly involved in post-transcriptional gene silencing. However, despite the biological significance of miRNAs, the roles of other miRNA-binding proteins (miRBPs) remain unclear in the regulation of miRNA loading, dissociation from RISCs and extracellular release. In this study, we performed protein arrays to profile miRBPs and identify 118 RBPs that directly bind to miRNAs. Among those proteins, the RBP quaking (QKI) inhibits extracellular release of the mature microRNA let-7b by controlling the loading of let-7b into extracellular vesicles via additional miRBPs such as AUF1 (also known as hnRNPD) and hnRNPK. The enhanced extracellular release of let-7b after QKI depletion activates Toll-like receptor 7 (TLR7) and promotes the production of proinflammatory cytokines in recipient cells, leading to brain inflammation in the mouse cortex. Thus, this study reveals the contribution of QKI to the inhibition of brain inflammation via regulation of extracellular let-7b release.
Muscle-Strengthening Activity among College Students: Who, What, Where, and Is It Enough?
Authors: Frederick Ginny M. , Boudreaux Benjamin D. , Evans Ellen M. , Schmidt Michael D. 
Published: September 2024

ABSTRACT

Introduction
Muscle-strengthening activity (MSA) is recommended for all major muscle groups ≥2 d·wk−1. Assessment is often based on the number of days per week of MSA without determining if all major muscle groups are being used, precluding accurate determination of compliance with physical activity (PA) guidelines. Thus, characteristics of MSA remain inadequately characterized, especially among college students. Although it is known that males engage in more MSA than females across the lifespan, more detailed information regarding sex differences in this behavior is needed. The purpose of this study was to comprehensively describe MSA among male and female college students to a) characterize adherence to MSA guidelines according to frequency of MSA and number of muscle groups used, and b) explore sex differences in MSA.

Methods
College students (n = 651, 79.1% female, 20.3 ± 1.3 yr old) reported frequency of participation in MSA, muscle groups used, types of MSA performed, and location of MSA engagement via online questionnaires. The proportion of students meeting public health recommendations for MSA and characteristics of MSA participation were analyzed for the total sample and separately for male and female students.

Results
The proportion of students meeting MSA recommendations ranged from 9.8% to 52.7% depending on the minimum number of muscle groups required. Regardless of criteria, males were more likely to meet PA guidelines and reported more days of MSA, more muscle groups used, more types of MSA, and MSA at more locations than females (all P ≤ 0.05).

Conclusions
Estimates of compliance with MSA guidelines vary substantially depending upon the number of muscle groups required for compliance. Frequency of MSA and specific muscle groups worked should be included as part of MSA assessment to align with PA guidelines. Sex differences also influence MSA participation; thus, tailoring of messages and programming may improve MSA participation on college campuses.
The effects and benefits of creatine supplementation on brain health
Authors: Sztemberg Elena , Łepecki Dominik , Grodziński Bartłomiej , Tomaszewski Robert , Mikusek-Pham Van Marcin , Krawiel Karolina , Kras Marta , Król Marek , Cieślik Aleksandra , Gruszczyńska Hanna 
Published: September 2024

Introduction: Creatine is a naturally occurring compound vital for energy metabolism, particularly in high-energy-demand tissues like muscles and the brain. Traditionally, research on creatine has focused on its ergogenic effects in sports, but emerging research suggests it may also positively impact brain health. Studies are exploring creatine monohydrate's role in improving cognitive function, mitigating neurodegenerative processes, and supporting mental health. This dual functionality highlights the compound's versatility as both a performance enhancer and a potential therapeutic agent for neurological health. By expanding the scope of creatine research beyond physical performance, we can better understand and utilize its full capabilities to enhance human health. This research review examines the growing evidence suggesting that creatine supplementation could significantly benefit brain health and the management of neurological diseases. Aim of the study: This review aims to synthesize current findings on creatine's cognitive benefits and its therapeutic potential for neurological disorders, critically analyzing preclinical and clinical studies to identify gaps and suggest future research directions.Materials and Methods: A comprehensive literature search was conducted using PubMed and Google Scholar databases, covering studies published between 2000 and 2024. Keywords such as creatine supplementation, brain health and neurodegeneration were used. Exclusion criteria included non-peer-reviewed articles, studies with insufficient data, and those not in English. Conclusions: This review highlights the potential benefits of creatine supplementation for cognitive and neurodegenerative diseases, noting its positive effects on memory, alleviating depression and anxiety, and offering neuroprotection. Future research should aim to standardize dosing, extend follow-up periods, and include larger, more diverse populations.
Will melatonin supplementation become a new form of obesity treatment? A review of recent literature.
Authors: Żak Natalia , Błaszczyk Aleksandra , Pażyra Aldona , Kusak Natalia , Jaworska Barbara , Stanicki Paweł 
Published: September 2024

Background: In 2020, the World Health Organization (WHO) estimated that 650 million adults worldwide are obese, and 2.8 billion individuals struggle with overweight. Obesity is associated with an increased risk of cardiovascular diseases, type 2 diabetes, heart disease, adverse effects on mental health, the development of certain cancers, and other conditions. In recent years, there has been growing interest in the role of melatonin, which has therapeutic potential in the treatment of obesity. Studies suggest that melatonin supplementation may lead to weight reduction and improvement in metabolic parameters, significantly reduce cardiovascular disease risk factors, and enhance insulin sensitivity in obese individuals.
Aim of study: This review aims to present the latest scientific findings on the impact of melatonin supplementation on the development of obesity and its complications. We focus primarily on the mechanisms of melatonin's action in the context of obesity, particularly on potential pathways that have not yet been thoroughly explored. Our aim is to provide deeper insights into research on obesity and its prevention.
Materials and Methods: Search was conducted using PubMed and Google Scholar databases, utilizing the keywords "obesity," "melatonin," and "weight loss" in various configurations. The review primarily considers studies published after 2016 that are available online.
Summary
Melatonin supplementation leads to a statistically significant reduction in blood glucose levels and an increase in cellular insulin sensitivity. Its promising properties in the treatment of obesity have been demonstrated through the reduction of oxidative stress, indicating a potential adjunct for weight loss. Based on the cited studies, the beneficial effects of melatonin supplementation on cardiovascular risk factors have been confirmed. Melatonin could be considered as an adjunctive therapy for obese individuals who do not respond to other treatment modalities.
Methods of surfactant administration in newborn. Literature review
Authors: Głoskowska Julia , Frańczuk Agata , Kuleta Katarzyna , Dyl Tomasz , Kruk Adrian , Gruszczyńska Hanna , Szpulak Angelika , Kopczyńska Ewelina , Makłowicz Aleksandra , Peregrym Michał 
Published: September 2024

The most common cause of respiratory distress syndrome (RDS) in neonates born prematurely is surfactant deficiency. Surfactant administration has been the method of choice for the treatment of RDS since the 1990s, only the method of delivery is changing with the use of increasingly less invasive methods of respiratory support in neonatal respiratory failure. For many years, the standard method was the administration of surfactant after intubation through an endotracheal tube during artificial ventilation. Gradually, new methods were introduced to reduce or avoid the use of ventilation (INSURE), followed by methods that bypass intubation (LISA). The latest SALSA technique made it possible to omit the use of a laryngoscope and the need for intubation. The new methods of surfactant administration can be used successfully in newborns requiring only non-invasive respiratory support, in neonatal centers in regions with limited access to specialized medical care.
Stock Return Autocorrelations and Expected Option Returns
Authors: Jeon Yoontae , Kan Raymond , Li Gang 
Published: September 2024

We show that the return autocorrelation of underlying stock is an important determinant of expected equity option returns. Using an extended Black-Scholes model incorporating the presence of stock return autocorrelation, we demonstrate that expected returns of both call and put options are increasing in the return autocorrelation coefficient of the underlying stock. Consistent with this insight, we find strong empirical support in the cross-section of average returns of equity options. Our paper highlights the necessity to control for stock return autocorrelation when studying option return predictability. This paper was accepted by Agostino Capponi, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.03071 .
Colorectal Neuroendocrine Neoplasm Detection Rate During Colonoscopy: Results From Large-Scale Data of Colonoscopies in Japan
Authors: Sekiguchi Masau , Kawamura Takuji , Horiguchi Go , Mizuguchi Yasuhiko , Takamaru Hiroyuki , Toyoizumi Hirobumi , Kato Masayuki , Kobayashi Kiyonori , Sada Miwa , Oda Yasushi , Yokoyama Akira , Utsumi Takahiro , Tsuji Yosuke , Ohki Daisuke , Takeuchi Yoji , Shichijo Satoki , Ikematsu Hiroaki , Matsuda Koji , Teramukai Satoshi , Kobayashi Nozomu , Matsuda Takahisa , Saito Yutaka , Tanaka Kiyohito 
Published: September 2024

INTRODUCTION:
This study investigated the detection rate of colorectal neuroendocrine neoplasms (NENs) using large-scale colonoscopy data.

METHODS:
This cross-sectional analysis used large-scale data from a Japanese multicenter observational study of colonoscopies performed from 2010 to 2020.

RESULTS:
Among 82,005 colonoscopy cases, colorectal NENs were identified in 71 (67 of which were neuroendocrine tumors), with a detection rate of 0.087% (95% confidence interval: 0.069–0.109). Most were small rectal lesions, with only 4 >10 mm in size and 3 located in the colon.

DISCUSSION:
The detection rate of colorectal NENs during colonoscopy is substantially higher than expected.
Methodology for the Selection of Risk Response Actions while Considering Corporate Objectives in the Metalworking Industry
Authors: Cuadros-López Álvaro Julio , Bustos-Useche Alexander , Bustos-Useche Leonardo 
Published: September 2024

Context: Projects in metalworking companies are affected by risk. Proper risk management depends on the responses provided to improve the project plan. However, multiple potential actions may result in constraints due to multiple factors. The purpose of this article is to propose a hybrid approach to solve the problem of selecting risk response actions while considering strategic objectives, fuzzy logic, and simulation.
Method: First, 334 risks were identified through a literature review and a discussion with experts. These were then filtered, resulting in 70 operational risks. Subsequently, the ten critical risks were prioritized using the risk matrix. Then, using Monte Carlo simulation and correlation analysis, the activities most affected by the risks were identified. Finally, potential response actions were designed for each case, and fuzzy logic and quality function deployment were applied to evaluate them.
Results: The selected responses were framed within the strategic objectives, i.e., customer satisfaction, business profitability, and implementation of new technologies. This, while considering some corporate attributes that the actions had to meet finishing the project on time, having low costs, and meeting the scope. The selected actions had a better profile than others seeking to minimize time or costs.
Conclusions: EPCC projects are complex and often suffer from gaps in scope, time, and cost. Risk analysis and the selection of responses in the planning phase help to improve performance. This study developed a risk response plan for a project executed in Brazil. Risks were identified, classified, and mitigated using simulations, resulting in an 11-day reduction in the project’s estimated duration.
Community-Based Early Warning System Model for Stream Overflow In Barranquilla
Authors: Serna-Galeano Iván Andrés Felipe , Gómez-Vargas Ernesto , Camargo-López Julián Rolando 
Published: September 2024

Context: This work aims to design and create a community-based early warning model as an alternative for the mitigation of disasters caused by stream overflow in Barranquilla (Colombia). This model is based on contributions from social networks, which are consulted through their API and filtered according to their location.
Methods: With the information collected, cleaning and debugging are performed. Then, through natural language processing techniques, the texts are tokenized and vectorized, aiming to find the vector similarity between the processed texts and thus generating a classification.
Results: The texts classified as dealing with stream overflow are processed again to obtain a location or assign a default one, in order to for them to be georeferenced in a map that allows associating the risk zone and visualizing it in a web application to monitor and reduce the potential damage to the population.
Conclusions: Three classification algorithms were selected (random forest, extra trees, and k-neighbors) to determine the best classifier. These three algorithms exhibited the best performance and R2 regarding the data processed in the regressions. These algorithms were trained, with the k-neighbor algorithm exhibiting the best performance.
Farmacogenética del cáncer colorrectal en un hospital terciario de Valencia
Authors: Comes-Raga Ana , Sendra Luis , Marcaida-Benito Goitzane , Aliño Salvador F. , Herrero María José 
Published: September 2024

Resumen

Objetivos
Las variaciones genéticas que afectan a procesos farmacocinéticos y farmacodinámicos influyen en la aparición de reacciones adversas y supervivencia de pacientes en tratamiento de cáncer colorrectal.

Métodos
Se realizó una selección de variantes genéticas según la quimioterapia pautada junto con las bases de datos farmacogenéticas. El genotipado se realizó con la tecnología MassArray (Agena Bioscience). Se realizaron estudios de asociación entre variantes-toxicidad y supervivencia-genotipo con métodos de regresión logística (SPSS ver. 28.0.1.1).

Resultados
Se realizó el genotipado de 25 SNPs en 96 pacientes. Para el gen DPYD, un 3,5 % presentaron la mutación rs75017182, 4,7 % rs1801158 y 7,1 % rs1801160. Las frecuencias genotípicas en el gen UGT1A1 fueron 39,4 % (*1/*1), 37,9 % (*1/*28), 19,7 % (*28/*28), y 3 % (*1/*36).
Los genotipos CT de la variante rs1801160, AT de la variante rs67376798 (DPYD), y *1/*36 (UGT1A1), se relacionaron con eventos de menor supervivencia (p-valor: 0.006, <0.001, y 0.052, respectivamente). La reacción adversa más frecuente fue la gastrointestinal, seguida de neurotoxicidad. El genotipo CC (rs1801160, DPYD) se asoció con un menor riesgo de desarrollar toxicidad gastrointestinal grave, y CC (rs1801158, DPYD) con un menor riesgo de desarrollar toxicidad hematológica general y grave.

Conclusiones
Nuestro estudio ha puesto de manifiesto que existen diferencias en las frecuencias poblacionales de nuestra serie de pacientes para el rs1801160 y rs75017182 (DPYD), *1/*28, *28/*28 y *1/*36 (UGT1A1) y las descritas en población española. Se asoció una menor supervivencia del genotipo CT de rs1801160, el genotipo AT de la variante rs67376798 (DPYD), y 1/*36 (UGT1A1).