bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active suicidal ideation in an adolescent with autism spectrum disorder receiving methylphenidate: a case report
Authors: Kerkeni Ali , Pons Charles Olivier 
Published: October 2024

Abstract
Background
Methylphenidate is a psychostimulant treatment widely prescribed in children and adolescents with attention deficit hyperactivity disorder. Although published studies are reassuring regarding the safety and tolerability of this treatment in the short and long term, there are case studies that have reported the possibility of serious adverse effects following methylphenidate initiation in children and adolescents.

Case presentation
In the present study, we illustrate the case of a 13-year-old adolescent, who was diagnosed with autism spectrum disorder, attention deficit hyperactivity disorder, and other psychiatric comorbidities. The patient developed active suicidal ideation a few weeks after initiating methylphenidate. He also presented irritability accentuation, insomnia, decreased appetite, and an increase in temper tantrums after initiation of this treatment. Psychiatric evaluation, according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), did not reveal major psychiatric disorders that could explain them, particularly mood disorders. The risk of suicide was assessed as high indicating a hospitalization and the immediate discontinuation of this treatment. The evolution was marked by a disappearance of suicidal thoughts 2 days after discontinuation of methylphenidate and a clear decrease in symptoms of poor tolerance. The authors were unable to establish a cause-and-effect link between the prescription of methylphenidate and the appearance of suicidal thoughts in this patient, but the results of studies already published seem to provide clues that could explain this link.

Conclusions
The purpose of this work is to alert clinicians to the possibility that young people who have multiple neurodevelopmental disorders may experience suicidal thoughts after starting methylphenidate even in the absence of mood disorders. The link between the prescription of this treatment and the onset of suicidal ideation is not as clear and requires more controlled studies. This suggests particular attention, such as informing the young people and their families beforehand and planning rigorous psychiatric evaluations after the prescription.
Phase II Trial of Adjuvant S-1 Following Neoadjuvant Chemotherapy and Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: The PIECE Trial
Authors: Nomura Motoo , Yamaguchi Toshifumi , Chin Keisho , Hato Shinji , Kato Ken , Baba Eishi , Matsubara Hisahiro , Mukaida Hidenori , Yoshii Takako , Tsuda Masahiro , Tsubosa Yasuhiro , Kitagawa Yuko , Oze Isao , Ishikawa Hideki , Muto Manabu 
Published: October 2024

Abstract
Background
Neoadjuvant chemotherapy followed by surgery (NAC-S) is the standard therapy for locally advanced esophageal squamous cell carcinoma (ESCC) in Japan.

Objective
The aim of this phase II trial was to assess the efficacy and safety of the addition of adjuvant S-1 after R0 resection in ESCC patients who received NAC-S.

Patients and methods
Key eligibility criteria included clinical stage IB–III (without T4 disease) ESCC, age 20–75 years, and an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Patients received adjuvant therapy with four cycles of S-1 (80 mg/m2/day) administered orally for 4 weeks of 6-week cycles. The primary endpoint was 3 year relapse-free survival (RFS). If the lower confidence limit for 3 year RFS was >50%, we judged that the primary endpoint of this study was met.

Results
A total of 52 patients were enrolled between January 2016 and January 2019. Two patients were excluded from analysis; five patients were determined to have R1 or R2 resection, and seven patients did not receive adjuvant S-1. The 3-year RFS and overall survival rates in the intention-to-treat population were 72.3% (90% confidence interval [CI] 59.9–81.5) and 85.0% (90% CI 73.9–91.6), indicating that the primary endpoint was met. Grade ≥3 adverse events with an incidence ≥10% included neutropenia (13.2%), anorexia (13.2%), and diarrhea (10.5%). There were no treatment-related deaths.

Conclusion
Adjuvant S-1 after NAC-S showed promising efficacy with a manageable safety profile for patients with resectable ESCC and warrants further evaluation in larger studies.
More Than Just Another Elbow Tendinopathy: A Case Series of Misdiagnosed Ulnar Nerve Compression and Review of Common Upper Extremity Misdiagnoses in Climbing
Authors: Meller Leo L.T. , Allen Matthew R. , Sigua Logan H. , Hooper Jason , Vitale Kenneth 
Published: October 2024

Abstract
Climbing is an increasingly popular sport. Yet, we have encountered numerous misdiagnosed climbing injuries, highlighting a gap in climbing-related literature and a need for heightened awareness within the sports medicine community. We present a case series that highlights the clinical manifestation of ulnar nerve entrapment and compression in three patients with initially misdiagnosed and mismanaged elbow tendinopathy. After a correct diagnosis of ulnar nerve pathology was made, each patient underwent a prescribed rehabilitation protocol that focused on nerve motility exercises (tensioning and flossing), resulting in a significant reduction in pain and a successful return to their pre-injury climbing performance. We thus aim to raise awareness of this often-mistreated presentation. Furthermore, we highlight other common upper extremity climbing misdiagnoses and provide relevant clinical recommendations to accurately identify and manage such injuries in climbers.
Violência Colonial e Efeitos Psicossociais: Diálogo entre Experiências Kaiowá e Guarani e Escritos de Martín-Baró
Authors: De Faria Lucas Luis , Martins Catia Paranhos 
Published: October 2024

Este texto é parte da relação dialógica que temos construído com os povos Kaiowá e Guarani de Mato Grosso do Sul a partir do ensino e pesquisa em Psicologia Social. Nesta pesquisa nos debruçamos sobre as narrativas de violência denunciadas por estes povos para tecer análises de seus efeitos psicossociais a partir das contribuições de Ignacio Martín-Baró. Os relatos das violências coloniais, por suas relações intrínsecas com a colonização, são oriundos de recortes de notas da Aty Guasu, organização Kaiowá e Guarani, e da escuta sensível de diferentes comunidades e pessoas violentadas. O acesso às notas deu-se através das publicações no blog da Aty Guasu entre os anos de 2011 e 2013. Utilizamos as estratégias metodológicas de revisão da literatura da Psicologia da Libertação, a análise de documentos e o registro em diário de campo quando da participação em atividades públicas protagonizadas pelos Kaiowá e Guarani. Por meio desses procedimentos interpelamos a multiplicidade da violência colonial, como os homicídios e suicídios, praticada por diferentes atores. Com este estudo, consideramos a substantivação da violência em seus termos e raízes coloniais como modo de compreender, intervir e enfrentar as relações violentas fundadas no colonialismo e perpetuadas por suas atualizações na contemporaneidade.
Below-knee amputation with an ultrasonic scalpel: evaluation of early postoperative clinical outcomes
Authors: Ryoo Hyun Jung , Lee Yeon Ji , Lim Jin-Soo , Shim Hyung-Sup 
Published: October 2024

Objective: Despite the development of microscopic reconstructive techniques for lower limb salvage, major limb amputation is still required for critical, unsalvageable lower leg wounds, with steadily increasing estimates of major limb amputations. In this study, the authors highlight a surgical technique for below-knee (BK) amputation using an ultrasonic scalpel, and evaluate its safety and effectiveness compared with the conventional method of using surgical blades. Method: A retrospective chart review was conducted at the Department of Plastic and Reconstructive Surgery, St. Vincent's Hospital, Republic of Korea, on patients who underwent BK amputation between October 2012 and January 2021. Patients were assigned to two groups: amputation using classical methods, such as surgical blades and electrocautery (group A); and amputation using an ultrasonic scalpel (group B). Numerous perioperative factors, such as operation time, intraoperative blood loss, postoperative complications and recovery time were examined. The present study adhered to the STROBE guidelines. Results: A total of 41 patients (16 in group A and 25 in group B) were included in this study. Operation time was significantly shorter in group B (p=0.001) and intraoperative blood loss was lower (p=0.011). Wound healing time did not vary between groups. Conclusion: In this study, the use of an ultrasonic scalpel for lower limb amputation was effective in reducing operation time and blood loss, which may be helpful in improving outcomes for patients with comorbidities.
Injusticias del pasado y justicia espacial en el barrio indígena de Sutiaba (León, Nicaragua)
Authors: Musset Alain Jean 
Published: October 2024

La reparación de las injusticias del pasado es un tema de actualidad directamente relacionado con el gran movimiento de reconquista, liberación o descolonización de las memorias que se aceleró a raíz del asesinato de George Floyd en 2020 por un policía blanco. Hasta ahora, la dimensión geográfica del problema ha sido raramente tratada como si esta temática no hiciera parte del campo político y académico de la justicia espacial, excepto bajo la forma de unos cuantos lugares destacados de la memoria colectiva en los cuales se expresan los valores de comunidades oprimidas. Al enfocarnos más particularmente en la comunidad indígena de Sutiaba (León, Nicaragua) examinaremos cómo y porqué lo que se considera una “injusticia histórica” es un elemento tanto físico como simbólico de la justicia espacial y puede servir para diseñar y estructurar un territorio basado en una identidad compartida y en una memoria a veces instrumentalizada.
Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes
Authors: de Abreu Almeida Marcos , Baeza Lilian Cristiane , Silva Leandro B. R. , Bernardes-Engemann Andréa Reis , Almeida-Silva Fernando , Coelho Rowena Alves , de Andrade Iara Bastos , Corrêa-Junior Dario , Frases Susana , Zancopé-Oliveira Rosely Maria , Alanio Alexandre , Taborda Carlos Pelleschi , Almeida-Paes Rodrigo 
Published: October 2024

Background
Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity against Histoplasma capsulatum, the dimorphic fungus that causes histoplasmosis, has not been properly addressed. Since there are few therapeutic options for this life-threatening systemic mycosis, this study evaluated the effects of auranofin on H. capsulatum growth and expression of virulence factors.

Methodology/principal findings
Minimal inhibitory and fungicidal concentrations (MIC and MFC, respectively) of auranofin against 15 H. capsulatum strains with distinct genetic backgrounds were determined using the yeast form of the fungus and a microdilution protocol. Auranofin activity was also assessed on a macrophage model of infection and on a Tenebrio molitor invertebrate animal model. Expression of virulence-related genes was compared between auranofin treated and untreated H. capsulatum yeast cells using a quantitative PCR assay. Auranofin affected the growth of different strains of H. capsulatum, with MIC and MFC values ranging from 1.25 to 5.0 μM and from 2.5 to >10 μM, respectively. Auranofin was able to kill intracellular H. capsulatum yeast cells and conferred protection against the fungus in the experimental animal model of infection. Moreover, the expression of catalase A, HSP70, superoxide dismutase, thioredoxin reductase, serine proteinase, cytochrome C peroxidase, histone 2B, formamidase, metallopeptidase, Y20 and YPS3 proteins were reduced after six hours of auranofin treatment. CONCLUSIONS/SIGNIFICANCE: Auranofin is fungicidal against H. capsulatum and reduces the expression of several virulence-related genes, which makes this anti-rheumatic drug a good candidate for new medicines against histoplasmosis.
Weight perception and mental health disorders among adolescents of central-eastern Tunisia: A cross-sectional study
Authors: Ghammem Rim , Ghali Hela , Pavicic Laura , Ben Fredj Sihem , Zammit Nawel , Dalhoumi Amira , Bannour Rania , Maatoug Jihene , Ghannem Hassen 
Published: October 2024

Background
The physical changes that accompany the onset of puberty demand a constant restructuring of the adolescent’s perception of their body and may influence adolescents’ mental health.

Aim
To describe weight status perception and its association with socio-demographic characteristics (SDC) and mental health disorders among adolescents in a low and middle-income country (LMIC).

Methods
We conducted a cross-sectional study in high schools in the urban area of the governorate of Sousse, Tunisia in 2018. We included in our study all students studying in selected classes in selected public high schools and who are consented to participate. Multinomial logistic regression was used to assess the associated factors to weight perception categories.

Results
The total number of students participating was 1399 with a response rate of 86.68%. The female sex was predominant (60.5% versus 39.5%). The mean age was of 17.03 ± 1.51 years. According to multivariate analysis, perceived weight categories were associated with sociodemographic factors such as gender and maternal educational level. Adolescents perceiving themselves as obese were at risk for severe depression (aOR = 0.40; p = 0.033). The BMI was associated with weight misperception: adolescents with normal weight tend to overestimate their weight (obesity aOR  =  0.13, p  =  0.017; overweight aOR  =  0.1, p  =  0.001).

Conclusion
There was a clear discrepancy between the actual weight status of the teens and their self-perceived weight. Adolescents are still growing both physically and mentally, and forming their self-image. Thus, health promotion practices designed to create accurate perceptions of current body weight need to be part of prevention efforts.
An exploration of teacher and school-based nurse perceptions of current HPV education offered to students 15–16 years old in post-primary schools in Northern Ireland, UK
Authors: Flood Terri , McLaughlin Dr. Marian , Wilson Dr. Iseult , Hughes Ciara M. 
Published: October 2024

Introduction
Human papillomavirus virus (HPV) is highest among young adults 15–24 years old. High-risk strains are responsible for the development of cancers including cervical, vaginal, vulvar, anal, oropharyngeal and penile. Despite HPV school-based vaccination programmes in the UK, HPV vaccination uptake rates continue to fluctuate due to misinformation and vaccine hesitancy post COVID-19. The aim of this study is to explore perceptions of post-primary school teachers and nurses regarding the current HPV education provision and the need to provide HPV education to students 15–17 years old when they are most likely to be becoming sexually active.

Methods
A qualitative study was conducted using online semi-structured interviews between February-August 2022 with post-primary teachers and nurses in Northern Ireland, UK. Stratified random sampling was used to contact schools to recruit participants. Recruitment continued until data saturation was reached. Braun & Clarke’s six-phase framework for reflexive thematic analysis was used to analyse the data.

Results
Twelve teachers and six nurses participated in the study. Four themes arose based on the analysis including 1) the importance of HPV education 2) self-consent to the HPV vaccine 3) design of the HPV education and 4) delivery of the HPV education. Identified barriers to implementation of HPV education included lack of parental education, religion and the conservative culture of Northern Ireland.

Discussion
Participants perceived HPV education to be poor or non-existent in their schools but placed high importance on this education. They indicated that a non-judgemental health professional would be the ideal person to deliver interactive HPV education as part of a mandated spiral curriculum.

Conclusion
HPV education at 15–17 years old provides students with an opportunity to learn about their HPV risk, their HPV vaccination status and an opportunity to self-consent to the HPV vaccine. The Education Authority and Department of Health should support health professionals to deliver consistent robust HPV health information to students of this age.
An insurmountable obstacle: Experiences of Chinese women undergoing in vitro fertilization
Authors: Ying Xunxun , Zhou Yunxian , Jin Yang , Wu Danhong , Kong Lingling , Dong Pingpei , Xu Xiuling 
Published: October 2024

Objective
This study aimed to explore the perceptions of women who have undergone unsuccessful in vitro fertilization (IVF) in Hangzhou, Zhejiang Province, China, and to explore how treatment failure has impacted their lives and relationships, thereby enabling the public to understand the unique experiences of these women.

Design
A descriptive qualitative approach was employed, with purposive sampling used to recruit participants from the gynecological department of a traditional Chinese medicine clinic at a large tertiary hospital in Zhejiang province. Twelve women undergoing IVF treatment was involved in the study. Data were collected through face-to-face semi-structured interviews, which were transcribed verbatim. Conventional content analysis methods were used to analyze the data.

Results
Following analysis, three main categories emerged: 1) The Psychological Experience of Initial Miscarriage from IVF Treatment, 2) The Psychological Experience of Repeated Treatment Failure, and 3) Interpersonal experiences and challenges. Women experiencing initial failure from IVF treatment reported emotions such as surprise, doubt, sadness, disappointment, and embarrassment. They perceived the process as harder than expected, leading to unexpected daily life challenges and difficulties in achieving success. As unsuccessful attempts persisted, they endured psychological suffering and lived in the shadow of repeated treatment failures. Doubts, perplexity, and anxiety grew, making reproduction seem like an insurmountable obstacle in their lives. In their interpersonal experience, women often felt guilt toward family, faced social isolation, and found it challenging to discuss IVF openly everywhere. They encountered a lack of understanding from others but also found mutual sympathy and support among people who shared similar experiences.

Conclusions
The study provided an insight into the suffering of Chinese women undergoing IVF treatment, highlighting the challenges of overcoming treatment failures. The findings not only inform Chinese infertile women considering IVF treatment but also contribute to the development of more effective support services by healthcare providers.
Quantifying the effect of interpregnancy maternal weight and smoking status changes on childhood overweight and obesity in a UK population-based cohort
Authors: Taylor Elizabeth J. , Ziauddeen Nida , Berrington Ann , Godfrey Keith M. , Alwan Nisreen A. 
Published: October 2024

Background
Maternal preconception and pregnancy exposures have been linked to offspring adiposity. We aimed to quantify the effect of changes in maternal weight and smoking status between pregnancies on childhood overweight/obesity (≥ 85th centile) and obesity (≥ 95th centile) rates in second children.

Methods
Records for 5612 women were drawn from a population-based cohort of routinely collected antenatal healthcare records (2003–2014) linked to measured child body mass index (BMI) age 4–5 years. We applied the parametric G-formula to estimate the effect of hypothetical changes between pregnancy-1 and pregnancy-2 compared to the natural course scenario (without change) on child-2 BMI.

Results
Observed overweight/obesity and obesity in child-2 at age 4–5 years were 22.2% and 8·5%, respectively. We estimated that if all mothers started pregnancy-2 with BMI 18·5–24·9 kg/m² and all smokers stopped smoking, then child-2 overweight/obesity and obesity natural course estimates of 22.3% (95% CI 21.2–23.5) and 8·3% (7·6–9·1), would be reduced to 18.5% (17.4–19.9) and 6.2% (5.5–7.0), respectively. For mothers who started pregnancy-1 with BMI 18·5–24·9 kg/m², if all smokers stopped smoking, child-2 overweight/obesity and obesity natural course estimates of 17.3% (16.0–18.6) and 5·9% (5·0–6·7) would be reduced to 16.0% (14.6–17.3) and 4·9% (4·1–5·7), respectively. For mothers who started pregnancy-1 with BMI ≥30 kg/m², if BMI was 18·5–24·9 kg/m² prior to pregnancy-2, child-2 overweight/obesity and obesity natural course estimates of 38.6% (34.7–42.3) and 17·7% (15·1–20·9) would be reduced to 31.3% (23.8–40.0) and 12.5 (8.3–17.4), respectively. If BMI was 25.0–29.9 kg/m² prior to pregnancy-2, these estimates would be 34.5% (29.4–40.4) and 14.6% (11.2–17.8), respectively.

Conclusion
Interventions supporting women to lose/maintain weight and quit smoking between pregnancies could help reduce rates of overweight/obesity and obesity in second children. The most effective interventions may vary by maternal BMI prior to the first pregnancy.
(Post)War Trials of Nazi Perpetrators and Their Auxiliaries in the Soviet Union: History and Ongoing Debates
Authors: Makhalova Irina , Rebrova Irina 
Published: October 2024

Abstract
The article briefly outlines the current state of scholarly literature devoted to ongoing debates on the history and role of war- and postwar open and closed trials of Nazi perpetrators and their auxiliaries in the Soviet Union. Having become partly available for historians more than two decades ago, these trials proceedings constitute a unique source for analyzing various aspects of the Second World War on the Eastern front, including the Holocaust. This article describes the legal basis for prosecuting Nazi criminals (in the 1940s) and Soviet collaborators (mainly from the 1940s until the 1970s) and summarizes ongoing debates concerning the nature and peculiarities of both closed and open Soviet war crimes trials with an outline of the main topics for further research.
From aspect to information structure: Non-aspectual functions of change of state markers in Austronesian and beyond
Authors: Mazzitelli Lidia Federica 
Published: October 2024

Abstract
This paper discusses a phenomenon that has so far received little attention in previous literature: the presence, in several languages from different branches of the Austronesian family, of polyfunctional markers, which combine an aspectual meaning of change of state with information and discourse structuring functions. In this study, based on a comparative analysis of fifty-two Austronesian languages, I show that polyfunctional change of state markers are distributed throughout the entire family, crosscutting the major typological and geographical divide between Western and Eastern Austronesian. I argue that the development of information and discourse structuring functions of change of state markers derives from applying the notions of current relevance and transition to new situation not to eventualities, but to elements of propositions, and I also suggest that this process may be universally valid and could explain the similar development of change of state markers into information and discourse structuring devices attested in non-Austronesian languages.