bluuebunny/crossref_metadata_2025_split huggingface dataset:
Findings from the 2017 Yearbook Section on Health Information Management
Authors: Bloomrosen M. , Berner E. S. 
Published: October 2017

Summary
Objectives: To summarize the recent literature and research and present a selection of the best papers published in 2016 in the field of Health Information Management (HIM).
Methods: A systematic review of the literature for the IMIA Yearbook HIM section was performed by the two section editors with the help of a medical librarian. We searched bibliographic databases for HIM-related papers were searched using both MeSH headings and key words in titles and abstracts. A shortlist of candidate best papers was first selected by section editors before being peer-reviewed by independent external reviewers.
Results: The five papers selected as ‘Best Papers’ illustrate a variety of themes, include authors from a variety of countries, and were published in some of the best journals in the field. The themes of the five best papers include health information exchange, personal health records, patient engagement, data quality, and e-quality measures.
Conclusions: The discipline of Health Information Management is increasingly becoming allied with the field of Biomedical Informatics in that both disciplines have interests in common. Traditional HIM areas of expertise (in the pre-electronic health record world), such as coding and privacy and security of health information, are necessary for the electronic exchange and secondary use of health information. With the changes in healthcare delivery brought by the use of electronic health records, addressing issues of information governance is essential. This synopsis discusses these key issues at the intersection of HIM and informatics, examines the potential challenges, and points the way for best practices, future research, and public policy considerations and directions.
Present and Future Trends in Consumer Health Informatics and Patient-Generated Health Data
Authors: Lai A. M. , Hsueh P.-Y. S. , Choi Y. K. , Austin R. R. 
Published: October 2017

Summary
Objectives: Consumer Health Informatics (CHI) and the use of Patient-Generated Health Data (PGHD) are rapidly growing focus areas in healthcare. The objective of this paper is to briefly review the literature that has been published over the past few years and to provide a sense of where the field is going.
Methods: We searched PubMed and the ACM Digital Library for articles published between 2014 and 2016 on the topics of CHI and PGHD. The results of the search were screened for relevance and categorized into a set of common themes. We discuss the major topics covered in these articles.
Results: We retrieved 65 articles from our PubMed query and 32 articles from our ACM Digital Library query. After a review of titles, we were left with 47 articles to conduct our full article survey of the activities in CHI and PGHD. We have summarized these articles and placed them into major categories of activity. Within the domain of consumer health informatics, articles focused on mobile health and patient-generated health data comprise the majority of the articles published in recent years.
Conclusions: Current evidence indicates that technological advancements and the widespread availability of affordable consumer-grade devices are fueling research into using PGHD for better care. As we observe a growing number of (pilot) developments using various mobile health technologies to collect PGHD, major gaps still exist in how to use the data by both patients and providers. Further research is needed to understand the impact of PGHD on clinical outcomes.
Assessing the Structural Footprint of Minimally Invasive Brain Cannulation on Cerebral White Matter: A Cadaveric Model
Authors: Sivakanthan Sananthan , Ochalski Pawel , Schirda Claudiu , Engh Johnathan 
Published: October 2017

Background All brain surgery requires some degree of iatrogenic trauma to healthy tissue. Minimally invasive approaches to brain tumors offer the potential of decreasing this trauma compared with conventional approaches. However, there are no validated radiologic models to examine axonal damage after minimally invasive entry into the brain.
Objective To present a cadaveric model of brain cannulation using fractional anisotropy measurements obtained from diffusion tensor magnetic resonance imaging (MRI). Two different methods of access are compared.
Methods Freshly harvested unfixed cadaveric brains were cannulated using both direct and indirect (i.e., dilation followed by cannulation) methods. Specimens were subjected to 68-direction diffusion tensor imaging scans and proton-density imaging. Fractional anisotropy (FA) data from a region of interest surrounding the entry zone was extracted from scans using imaging software and analyzed.
Results FA values were significantly higher following indirect cannulation (less invasive method) than they were following direct cannulation. FA values for undisturbed brain were significantly higher than in either of the cannulated groups, suggesting an inverse relationship between FA values and brain injury.
Conclusion Axonal damage following brain cannulation can potentially be evaluated by FA analysis in a cadaveric model. These data may lead to an MRI-based model of iatrogenic brain injury following tumor surgery. Future studies will focus on histologic analysis and clinical validation in live tissues.
Preliminary Experience with a Novel System of Facet Fixation to Treat Patients with Lumbar Degenerative Disease. A New Perspective in Minimally Invasive Spine Surgery?
Authors: Francaviglia Natale , Costantino Gabriele , Villa Alessandro , Iacopino Domenico , Pappalardo Maria , Barone Fabio , Gallo Cristina , Contino Antonino , Meli Francesco , Maugeri Rosario 
Published: October 2017

Purpose We report our experience with a novel surgical device for the treatment of lumbar degenerative microinstability. Facet Wedge (DePuy Synthes, Raynham, Massachusetts, United States) is a novel technique of intra-articular lumbar facet fixation that provides a minimally invasive alternative to standard posterior fixation.
Materials and Methods From November 2014 to July 2015, 38 patients underwent single-level Facet Wedge implantation. The main surgical indications included herniated disk (18 patients), spinal canal and foraminal stenosis (14 patients), and Meyerding grade I degenerative spondylolisthesis (6 patients). All the patients showed radiologic signs of microinstability: hyperintensity in both facet joints (facet fluid signal) in T2-weighted magnetic resonance imaging and a black disk as a sign of degenerative disease. No slippage was evident at dynamic radiograph. After a period of conservative treatment (minimum of 6 months), surgery was performed. All patients' follow-up lasted over at least 12 months.
Results The low back visual analog scale score decreased significantly after surgery (from an average of 8.2 to 3.1 at final follow-up). Postoperatively, the Oswestry Disability Index showed a significant reduction (14.7 on average). No slippage or signs of adjacent segment degeneration was detected in neuroimaging follow-up.
Conclusion Facet Wedge allows facet fixation in lumbar degenerative microinstability. To the best of our knowledge, this is the first clinical series reported in the literature on this novel device.
Die Bedeutung des intestinalen Mikrobioms beim ischämischen Schlaganfall
Authors: Winek Katarzyna , Dirnagl Ulrich , Meisel Andreas 
Published: October 2017

ZusammenfassungExperimentelle und klinische Studien der letzten Jahre belegen die wichtige Rolle der intestinalen Mikrobiota für die Homöostase des Zentralnervensystems (ZNS), aber auch für die Pathophysiologie von ZNS-Erkrankungen. Dabei spielt u. a. der modifizierende Einfluss der Mikrobiota auf die periphere Immunantwort eine wichtige Rolle, die wiederum einen modulierenden Effekt auf die Neuroinflammation im ZNS haben kann. Hier fassen wir die verfügbaren experimentellen und klinischen Daten zur Bedeutung des Mikrobioms beim Schlaganfall zusammen: 1) Schlaganfall verändert die intestinale Mikrobiota; 2) Mikrobiota kann die Prognose nach Schlaganfall beeinflussen; 3) Mikrobiota spielt eine wichtige Rolle in der Pathogenese von (Risikofaktoren) des Schlaganfalls. Aufgrund der vorliegenden klinischen und experimentellen Ergebnisse stehen für die nächsten Jahre klinisch relevante Entdeckungen zur Bedeutung der Darm-Mikrobiota beim Schlaganfall an.
Acute Management of Anticoagulation-Associated Intracerebral Hemorrhage
Authors: Kuramatsu Joji , Gerner Stefan , Huttner Hagen , Schwab Stefan 
Published: October 2017

AbstractThe incidence of anticoagulation-associated intracerebral hemorrhage (OAC-ICH) is increasing along with demographic changes and patients requiring oral anticoagulation for atrial fibrillation. OAC-ICH is one of the most detrimental sub-types of hemorrhagic stroke, characterized by larger hemorrhage volumes, more frequent intraventricular hemorrhage, increased and prolonged hematoma enlargement. The impact of these outcome predictors’ results in greater mortality rates and larger numbers of patients left in functionally dependent states after ICH. Yet, evidence on treatment options for these severely affected patients remains limited, resulting in weak recommendations by international and European guidelines. Minimization of hematoma enlargement constitutes the main focus of acute care, possibly achieved by blood pressure and reversal management. In all OAC-ICH patients irrespective of anticoagulation agent, immediate and aggressive blood pressure reductions as fast as possible targeting systolic blood pressure levels of 140 mmHg (at least within 4–6 h) seems reasonable. Specifically, in vitamin-K-associated ICH, blood pressure reductions have been shown to be associated with reduced rates of hematoma enlargement. Reversal management in OAC-ICH should be carried out as quickly as possible, though accounting for the different anticoagulation agents used. In vitamin-K-associated ICH, recent large-sized multicenter investigations contributed to refining reversal strategies. One German-wide cohort study including roughly 1 200 patients identified for the first time beneficial target values to guide reversal treatment. Anticoagulation reversal should achieve INR values of less than 1.3 or 1.2 at least within 4 h after admission. Agents to be used comprise prothrombin complex concentrates (PCC), which may achieve faster and more complete reversal. This combined approach (blood pressure management and INR-reversal) was associated with significant reductions of hematoma enlargement and lower in-hospital mortality rates. For dabigatran-related bleeding complications, most recently an antidote (Idarucizumab) has been approved, which has been prospectively investigated and showed rapid and almost complete reversal as well as sufficient hemostasis. Currently, bleeding under the influence of factor-Xa inhibitors poses great difficulties because no antidote is available and efficacy of commonly used antagonizing agents, i. e., PCC or fresh-frozen plasma (FFP), has not been proven for clinical use. The main aim of the present review focuses on acute-care management of OAC-ICH and tries to depict treatment options based on the most current data. Moreover, current neurocritical-care therapies for ICH will be reviewed to identify relevant implications specific to OAC-ICH treatment.
Maternal Aneurysmal Subarachnoid Hemorrhage During Pregnancy as an Interdisciplinary Task
Authors: Fritzsche Friederike , Regelsberger Jan , Schmidt Nils , Müller Jakob , Buhk Jan , Diemert Anke , Westphal Manfred , Martens Tobias 
Published: October 2017

AbstractMaternal aneurysmal subarachnoid hemorrhage (aSAH) during pregnancy presents a challenge regarding treatment and management. Due to the limited number of cases there are no treatment guidelines available. Thus, treatment is usually done on a case-by-case basis. Here we report on four cases of aSAH during pregnancy, describing the different management strategies and suggesting a possible treatment algorithm. Patients treated between 2003 and 2013 in our center were included in this retrospective study. Clinical data focused on time management concerning gestation week (GW), microsurgical or endovascular treatment, and outcome of the patients and the fetuses. Results were compared to the present literature on this issue. Mean age was 30.8 years, initial Hunt & Hess (H&H) grade ranged from III to V. All patients suffered from aSAH during the 3rd trimester of pregnancy. In the four cases, two emergency Caesarean sections (CS) were performed. Two aneurysms were occluded by microsurgical clipping and one was treated endovascularly. One patient died before definitive treatment of the aneurysm could be achieved, whereas fetal mortality was 0%. The mean follow-up was 83 months. aSAH during pregnancy needs individualized interdisciplinary management. Efforts must focus on the mother so that a delay in the best available treatment for the pregnant patient is avoided. Therefore treatment modality should be primarily determined by the aneurysm itself. However, timing in terms of delivery of the fetus and aneurysm treatment is a crucial point.
Allocating dissipation across a molecular machine cycle to maximize flux
Authors: Brown Aidan I. , Sivak David A. 
Published: October 2017

Significance
Cells use molecular machines to complete many tasks. These machines consume free energy to operate, typically by converting a high-concentration chemical into a low-concentration one. Each step of a machine’s operating cycle consumes some free energy, and different allocations of the available free energy among the machine steps lead to different machine speeds. We show that the speed-maximizing allocation is not even, instead depending on the timescales of the various steps. Models fit to experimental molecular machine dynamics often find similarly uneven free energy use. Deviations from the optimal allocation can drastically slow machine operation, suggesting a significant functional advantage to machines with dissipation allocation that is tuned to improve speed.
Evolutionary genomics of grape (
Vitis vinifera
ssp.
vinifera
) domestication
Authors: Zhou Yongfeng , Massonnet Mélanie , Sanjak Jaleal S. , Cantu Dario , Gaut Brandon S. 
Published: October 2017

Significance
We generated genomic data to estimate the population history of grapes, the most economically important horticultural crop in the world. Domesticated grapes experienced a protracted, 22,000-y population decline prior to domestication; we hypothesize that this decline reflects low-intensity cultivation by humans prior to domestication. Domestication altered the mating system of grapes. The sex determination region is detectable as a region of heightened genetic divergence between wild and cultivated accessions. Based on gene expression analyses, we propose candidate genes that alter sex determination. Finally, grapes contain more deleterious mutations in heterozygous states than do their wild ancestors. The accumulation of deleterious mutations is due in part to clonal propagation, which shelters deleterious recessive mutations.
Narrative persuasion
Authors: Fitzgerald Kaitlin , Green Melanie C. 
Published: October 2017

Abstract
Narrative transportation theory is used to explain the processes that occur when an individual experiences a story. Transportation refers to the feeling of being immersed in a narrative, a state of cognitive, affective, and mental imagery engagement. Transportation can occur across media for both factual and fictional stories, and is typically measured with a self-report scale (Green & Brock, 2000). Transportation is a key mechanism underlying narrative influence on recipients’ attitudes and beliefs. Narrative persuasion through transportation has been demonstrated with a variety of topics, including health, social issues, and consumer products. Transportation theory suggests several mechanisms to explain this phenomenon, including reduced counter arguing, connections with characters, heightened perceptions of realism, the formation of vivid mental imagery, and emotional engagement.
Towards a model for discourse marker annotation
Authors: Bolly Catherine T. , Crible Ludivine , Degand Liesbeth , Uygur-Distexhe Deniz 
Published: October 2017

Abstract
This chapter presents an empirical method for the identification and annotation of discourse markers (DMs) in in spontaneous spoken French (MDMA project). Central to the proposal is the assumption that DMs may be described as clusters of features that, in specific patterns of combination, allow to distinguish DM use from other linguistic items fulfilling a non-propositional function, such as modal particles or pragmatic markers. The hypothesis underlying the annotation experiment is that the analysis of the distributional constraints imposed on specific markers should uncover reliable features for the identification and categorization of DMs. Multivariate statistics suggest a certain hierarchy between the different features under scrutiny, regarding their relevance and reliability, in the process of identifying DMs in context.
Fabrication and Physical Properties of Titanium Nitride/Hydroxyapatite Composites on Polyether Ether Ketone by RF Magnetron Sputtering Technique
Authors: Nupangtha W , Boonyawan D 
Published: October 2017

Abstract
Titanium nitride (TiN) coatings have been used very successfully in a variety of applications because of their excellent properties, such as the high hardness meaning good wear resistance and also used for covering medical implants. Hydroxyapatite is a bioactive ceramic that contributes to the restoration of bone tissue, which together with titanium nitride may contribute to obtaining a superior composite in terms of mechanical and bone tissue interaction matters. This paper aims to explain how to optimize deposition conditions for films synthesis on PEEK by varying sputtering parameters such as nitrogen flow rate and direction, deposition time, d-s (target-to-substrate distance) and 13.56 MHz RF power. The plasma conditions used to deposit films were monitored by the optical emission spectroscopy (OES). Titanium nitride/Hydroxyapatite composite films were performed by gas mixture with nitrogen and argon ratio of 1:3 and target-to-substrate distance at 8 cm. The gold colour, as-deposited film was found on PEEK with high hardness and higher surface energy than uncoated PEEK. X-ray diffraction characterization study was carried to study the crystal structural properties of these composites.
Sustaining our Natural Resources in the Face of Increasing Societal Demands on Agriculture: Directions for Future Research
Authors: Khanna Madhu , Swinton Scott M , Messer Kent D 
Published: October 2017

AbstractU.S. agriculture is vital to meeting a growing global population’s demand for food, fiber, feed, and fuel. Smart technologies, big data, and improvements in crop genetics present producers with promising new opportunities for meeting these needs. However, a changing climate and an expanding global population impose challenges to increasing crop and livestock production while sustaining the natural resource base and protecting environmental quality. Sustainable agricultural development will call for systems approaches to allocate land among competing uses, coupled with the adoption of conservation technologies incentivized by cost‐effective policies that have been based on evidence from sound economic, behavioral, biological, and technological research. This paper suggests directions for future research in nine key dimensions that can fill important gaps in the existing literature and build on new research methods and policy needs, as well as inform strategies for sustainable growth of agriculture.
PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine
Authors: Rawi Reda , Mall Raghvendra , Kunji Khalid , Shen Chen-Hsiang , Kwong Peter D , Chuang Gwo-Yu 
Published: October 2017

Abstract

Motivation
Protein solubility can be a decisive factor in both research and production efficiency, and in silico sequence-based predictors that can accurately estimate solubility outcomes are highly sought.

Results
In this study, we present a novel approach termed PRotein SolubIlity Predictor (PaRSnIP), which uses a gradient boosting machine algorithm as well as an approximation of sequence and structural features of the protein of interest. Based on an independent test set, PaRSnIP outperformed other state-of-the-art sequence-based methods by more than 9% in accuracy and 0.17 in Matthew’s correlation coefficient, with an overall accuracy of 74% and Matthew’s correlation coefficient of 0.48. Additionally, PaRSnIP provides importance scores for all features used in training. We observed higher fractions of exposed residues to associate positively with protein solubility and tripeptide stretches with multiple histidines to associate negatively with solubility. The improved prediction accuracy of PaRSnIP should enable it to predict protein solubility with greater reliability and to screen for sequence variants with enhanced manufacturability.

Availability and implementation
PaRSnIP software is available for download under GitHub (https://github.com/RedaRawi/PaRSnIP).

Supplementary information
Supplementary data are available at Bioinformatics online.
Krait: an ultrafast tool for genome-wide survey of microsatellites and primer design
Authors: Du Lianming , Zhang Chi , Liu Qin , Zhang Xiuyue , Yue Bisong 
Published: October 2017

Abstract

Summary
Microsatellites are found to be related with various diseases and widely used in population genetics as genetic markers. However, it remains a challenge to identify microsatellite from large genome and screen microsatellites for primer design from a huge result dataset. Here, we present Krait, a robust and flexible tool for fast investigation of microsatellites in DNA sequences. Krait is designed to identify all types of perfect or imperfect microsatellites on a whole genomic sequence, and is also applicable to identification of compound microsatellites. Primer3 was seamlessly integrated into Krait so that users can design primer for microsatellite amplification in an efficient way. Additionally, Krait can export microsatellite results in FASTA or GFF3 format for further analysis and generate statistical report as well as plotting.

Availability and implementation
Krait is freely available at https://github.com/lmdu/krait under GPL2 License, implemented in C and Python, and supported on Windows, Linux and Mac operating systems.

Supplementary information
Supplementary data are available at Bioinformatics online.