bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exhuming the Dead and Talking to the Living: The 1914 Fire at the Florida Industrial School for Boys—Invoking the Uncanny as a Site of Analysis
Authors: Jackson Antoinette T. 
Published: December 2016

SUMMARYThis article revisits the 1914 fire at the Florida Industrial School for Boys in Marianna, Florida. It resulted in the deaths of ten people and led to increased levels of public focus on the school's mission, purpose, and its day‐to‐day operational practices. Those who burned in the fire were buried on campus in the area known as “Boot Hill Cemetery.” Very little documentation about the history of the cemetery, or who is buried there, exists; and the exact locations of individual burials were never documented. In 2013, a University of South Florida (USF) research team began excavation of the burials located in the area of Boot Hill. Their efforts have been justified by requests from family members to learn about missing loved ones. Exhuming bodies of those who perished in the fire, as well as those who died at other times, demands that we think critically about what is recovered, what is invoked, and what is next and for whom. I introduce Freud's concept of “the uncanny” as a frame of reference for talking about things that surface when one recovers human remains or in some way revisits the site of a past, perhaps long‐hidden, traumatic event.
A Dermal Equivalent Engineered with TGF‐β3 Expressing Bone Marrow Stromal Cells and Amniotic Membrane: Cosmetic Healing of Full‐Thickness Skin Wounds in Rats
Authors: Samadikuchaksaraei Ali , Mehdipour Ahmad , Habibi Roudkenar Mehryar , Verdi Javad , Joghataei Mohammad Taghi , As'adi Kamran , Amiri Fatemeh , Dehghan Harati Mozhgan , Gholipourmalekabadi Mazaher , Karkuki Osguei Nushin 
Published: December 2016

AbstractTransforming growth factor beta‐3 (TGF‐β3) has been shown to decrease scar formation after scheduled topical applications to the cutaneous wounds. This study aimed to continuously deliver TGF‐β3, during the early phase of wound healing, by engineering a dermal equivalent (DE) using TGF‐β3 expressing bone marrow stromal cells (BM‐SCs) and human dehydrated amniotic membrane (hDAM). To engineer a DE, rat BM‐SCs were seeded on the hDAM and TGF‐β3 was transiently transfected into the BM‐SCs using a plasmid vector. Pieces of the dermal equivalent were transplanted onto the full‐thickness excisional skin wounds in rats. The process of wound healing was assessed by image analysis, Manchester Scar Scale (MSS), and histopathological studies 7, 14, 21, and 85 days after the excision. The results confirmed accurate construction of recombinant pcDNA3.1‐TGF‐β3 expression system and showed that the transfected BM‐SCs seeded on hDAM expressed TGF‐β3 mRNA and protein from day 3 through day 7 after transfection. After implantation of the DE, contraction of the wounds was measured from day 7 through 21 and analyzed by linear regression, which revealed that the rate of wound contraction in all experimental groups was similar. Histologic evaluation demonstrated that transfected BM‐SCs decreased retention and recruitment of the cells during the early stage of wound healing, decreased the formation of vascular structures and led to formation of uniformly parallel collagen bundles. MSS scores showed that TGF‐β3 secreting cells significantly improved the cosmetic appearance of the healed skin and decreased the scar formation. From these results, it could be concluded that transient secretion of TGF‐β3, during the early phase of healing, by BM‐SCs seeded on hDAM can improve the cosmetic appearance of the scar in cutaneous wounds without negatively affecting the process of wound repair.
Letter: reduction in chronic hepatitis B‐related hepatocellular carcinoma with anti‐viral therapy, including low‐risk patients – more questions than answers
Authors: Wei T.‐Y. , Wang C.‐C. 
Published: December 2016

Linked ContentThis article is linked to Lin et al papers. To view these articles visit https://doi.org/10.1111/apt.13774 and https://doi.org/10.1111/apt.13859.
In Good Times but Not in Bad: The Role of Managerial Discretion in Moderating the Stakeholder Management and Financial Performance Relationship
Authors: Shahzad Ali M. , Rutherford Matthew A. , Sharfman Mark P. 
Published: December 2016

AbstractWe examine the role of managers in controlling the positive impact of stakeholder management (SM) on firm financial performance (FP) in the long term. We develop and test competing hypotheses on whether managers act as “good citizens” or engage in “self‐dealing” when allowed greater discretion. We test our assertions using dynamic panel data analysis of a sample of 806 U.S. public firms operating in 34 industries over 5 years (2005–2009). Our results indicate a nuanced influence of managerial discretion contexts on the SM‐FP relationship. We infer that given more latitude in decision making, as long as the “going is good” managers act as good citizens, but otherwise they revert to managerial self‐dealing. In light of our results, firms designing governance mechanisms to encourage managers to balance the needs of both shareholders and stakeholders must remain cognizant of contextual contingencies.
Osteopontin‐deficiency disturbs direct osteogenesis in the process of achieving osseointegration following immediate placement of endosseous implants
Authors: Makishi Sanako , Saito Kotaro , Ohshima Hayato 
Published: December 2016

AbstractBackgroundThe role of osteopontin (OPN) in the process of achieving osseointegration following implantation remains to be clarified.PurposeThis study aimed to analyze the healing patterns of the bone‐implant interface after immediate placement of implants in the maxillae of 4‐week‐old Opn‐knockout (KO) and wild‐type (WT) mice.Materials and MethodsAfter maxillary first molars were extracted, cavities were prepared with a drill and titanium implants blasted with ceramic abrasives containing hydroxyapatite/β‐tricalcium phosphate were placed. Following fixation at 3, 5, 7, and 28 days after implantation, the samples were analyzed using immunohistochemistry, in situ hybridization, and an electron probe micro analyzer.ResultsTwo types of bone healing were observed in the process of achieving osseointegration: “direct osteogenesis,” where bone formation occurs at the implant surface, and “indirect osteogenesis,” where it does at the pre‐existing damaged bone surface in the WT mice. Direct osteogenesis occurred after the recruitment of tartrate resistant acid phosphatase‐positive cells and the deposition of OPN on the implant surface. In contrast, the rate of osseointegration or direct osteogenesis was significantly low, and cell proliferation was disturbed in the Opn‐KO mice.ConclusionsThese results suggest that Opn‐deficiency disturbs direct osteogenesis to lead the delayed osseointegration after immediate placement of endosseous implants.
Molecular evolution of Zika virus as it crossed the Pacific to the Americas
Authors: de Bernardi Schneider Adriano , Malone Robert W. , Guo Jun‐Tao , Homan Jane , Linchangco Gregorio , Witter Zachary L. , Vinesett Dylan , Damodaran Lambodhar , Janies Daniel A. 
Published: December 2016

AbstractZika virus was previously considered to cause only a benign infection in humans. Studies of recent outbreaks of Zika virus in the Pacific, South America, Mexico and the Caribbean have associated the virus with severe neuropathology. Viral evolution may be one factor contributing to an apparent change in Zika disease as it spread from Southeast Asia across the Pacific to the Americas. To address this possibility, we have employed computational tools to compare the phylogeny, geography, immunology and RNA structure of Zika virus isolates from Africa, Asia, the Pacific and the Americas. In doing so, we compare and contrast methods and results for tree search and rooting of Zika virus phylogenies. In some phylogenetic analyses we find support for the hypothesis that there is a deep common ancestor between African and Asian clades (the “Asia/Africa” hypothesis). In other phylogenetic analyses, we find that Asian lineages are descendent from African lineages (the “out of Africa” hypothesis). In addition, we identify and evaluate key mutations in viral envelope protein coding and untranslated terminal RNA regions. We find stepwise mutations that have altered both immunological motif sets and regulatory sequence elements. Both of these sets of changes distinguish viruses found in Africa from those in the emergent Asia–Pacific–Americas lineage. These findings support the working hypothesis that mutations acquired by Zika virus in the Pacific and Americas contribute to changes in pathology. These results can inform experiments required to elucidate the role of viral genetic evolution in changes in neuropathology, including microcephaly and other neurological and skeletomuscular issues in infants, and Guillain‐Barré syndrome in adults.
Chronic Conditions, Medical Out‐of‐Pocket Expenditure Burden, and Perceived Health
Authors: Anong Sophia T. , Ajongwen Patience , Chandwani Sheenu 
Published: December 2016

This study examined the impact of medical out‐of‐pocket expenditure burden on being in a state of poor or fair health. Expenditures were self‐reported payments for premiums, coinsurance, deductibles, and health services and supplies not covered by health insurance. The burden was measured as a ratio of total medical expenditures relative to family income. Supported by literature, several cutoffs (as opposed to just one threshold) were proposed to determine the critical point of increased health risk of medical financial burden. A treatment effects model was estimated recognizing that ratios are jointly influenced by other confounding factors such as chronic conditions. Data on 16,907 adults in the 2011 Medical Expenditure Panel Survey were analyzed. The researchers concluded that ratios exceeding 10% increased the probability of reporting poor or fair health status. However, estimating this relationship while accounting for insurance but ignoring the presence of chronic conditions completely reversed this relationship. Sensitivity analysis suggested that insurance for those with chronic conditions does not lessen the negative impact of high out‐of‐pocket burdens, which seem to affect their perceived health. Implications are discussed relative to the goals of the Affordable Care Act.
Comprehension of Indirect Meaning in Spanish as a Foreign Language
Authors: Taguchi Naoko , Gomez‐Laich Maria Pia , Arrufat‐Marques Maria‐Jose 
Published: December 2016

AbstractThis study investigated comprehension of indirect meaning among learners of L2 Spanish via an original computer‐delivered multimedia listening test. The comprehension of implied speaker intention is a type of indirect communication that involves the ability to understand implied intention by using linguistic knowledge, contextual cues, and the assumption of relevance (Taguchi, 2005, 2011). Since inferential processing involves parallel processing of all available signals, both linguistic and nonlinguistic, to interpret the indirect utterance (Sperber & Wilson, 1995), it is essential to incorporate multimedia input. By creating a multimedia comprehension test in Spanish, the study examined theoretical claims about inferential mechanisms and their applicability to L2 comprehension. Thirty‐two L2 Spanish learners in intermediate/advanced Spanish classes at a private U.S. university and 21 native Spanish speakers completed a listening test that assessed comprehension of three types of indirect meaning: indirect refusals, indirect opinions, and irony. These item types differed in terms of the degree of conventionality encoded and the extent of inferencing required for comprehension. Participants’ comprehension was analyzed for accuracy and comprehension speed. Results revealed a significant difference in L2 Spanish learners’ comprehension accuracy scores and response times across the three item types. Irony was the most difficult to comprehend for L2 Spanish learners. Conventionality did not facilitate comprehension because indirect refusals and opinions had the same accuracy scores. In terms of response times, indirect opinions were faster to comprehend than indirect refusals and irony items. Posthoc retrospective verbal interviews revealed that learners used a wide a range of verbal, nonverbal, and contextual cues to make inferences of indirect meaning.
Catheter Ablation for Atrial Fibrillation in Patients With Watchman Left Atrial Appendage Occlusion Device: Results from a Multicenter Registry
Authors: TURAGAM MOHIT K. , LAVU MADHAV , AFZAL MUHAMMAD R. , VUDDANDA VENKAT , JAZAYERI MOHAMMAD‐ALI , PARIKH VALAY , ATKINS DONITA , BOMMANA SUDHARANI , DI BIASE LUIGI , HORTON RODNEY , BAI RONG , SWARUP VIJAY , CHENG JIE , NATALE ANDREA , LAKKIREDDY DHANUNJAYA 
Published: December 2016

AF Ablation After WatchmanBackgroundThere have been an increasing number of atrial fibrillation (AF) patients with Watchman left atrial appendage occlusion (LAAO) device, requiring catheter ablation (CA) for maintenance of normal sinus rhythm. In this study, we describe our experience with the feasibility and safety of CA in patients with a preexisting Watchman LAAO device.MethodsThis was a retrospective multicenter AF registry of 60 patients with Watchman LAAO device who underwent CA for AF. Baseline clinical and procedural characteristics of the included subjects were retrieved from review of medical records and were analyzed.ResultsThe mean age was 72.7 ± 4.9 years and the mean CHADS2 score was 2.3 ± 0.6. All patients had successful pulmonary vein isolation (PVI). The left atrial appendage (LAA) was electrically active in 34 (56%) while reentrant tachycardia and AF triggers were seen in 17 (28%) patients. Electrical isolation was attempted in these 17 patients with only 10 achieving complete LAA isolation. Repeat imaging showed new peri‐device leaks in 30% (12/40) patients, while new significant peri‐device leaks (≥5 mm) were noted in 10% (10/40) of patients after RFA, respectively, requiring continuation of oral anticoagulation. There were a higher proportion of patients with severe peri‐device leaks (≥5 mm) after LAA isolation. However, >50% of those leaks sealed off on follow‐up transesophageal echocardiogram.ConclusionAF ablation is a feasible and safe in patients with preexisting Watchman LAAO device. Electrical isolation of the LAA could be difficult and when attempted can result in increased risk of short‐term peri‐device leak and recurrence of AT/AF in almost all patients.
Human Rights Conditionality in European Union Trade Negotiations: the Case of the EU–Singapore FTA
Authors: Mckenzie Lachlan , Meissner Katharina L. 
Published: December 2016

AbstractTrade policy is among the EU's most significant capabilities in promoting values including human rights. Yet trade policy and the EU's values‐based foreign policy are often in tension. Scholarship on the social dimension of trade policy has emphasized the tension between values and the EU's commercial interests. Human rights and conditionality clauses have not been the focus of analysis, yet conditionality is one of the EU's most visible links between the trade agenda and its values‐based foreign policy. Analyzing the EU's decision‐making in negotiating human rights conditionality, this paper employs the EU–Singapore free trade agreement and its negotiation as an in‐depth single case study. The tension between commercial interests and values results in decision‐makers promoting incoherent interests. We argue that organizationally defined preferences and issue salience circumscribed the Parliament's impact on decision‐making, resulting in concessions on human rights conditionality with Singapore.
Pilot of integrated, colocated neurology in a primary care medical home
Authors: Young Nathan P. , Elrashidi Muhamad Y. , Crane Sarah J. , Ebbert Jon O. 
Published: December 2016

AbstractRationale, aims, and objectivesNovel health care delivery models are needed to reduce health care use while delivering effective and safe care. We developed a model of a neurologist integrated and colocated in primary care leveraging “curbside,” electronic, and traditional consultations. Our objective was to examine the impact on health care resource use of diagnostic testing and referrals for face‐to‐face neurological consultation and adverse outcomes associated with electronic and curbside consultations.MethodsConsecutive patients from December 1, 2014, to March 13, 2015, were included in the analysis about whom contact was made between a primary care clinician and a colocated neurologist.ResultsOver 3.5 months of the pilot, 359 unique patients generated 429 consultations (179 curbsides, 68 electronic consultations, and 182 face‐to‐face visits). The integrated model resulted in avoidance of 78 face‐to‐face tertiary neurology consultations, 39 brain magnetic resonance imaging, 50 electromyograms, and 53 other advanced imaging studies. Earlier curbside consultation may have prevented unnecessary testing or face‐to‐face tertiary neurology consultations in 40 (22%) patients. Earlier face‐to‐face consultation may have avoided expensive testing in 31 (17%) patients. No cases met criteria for an adverse outcome. The number of referrals to tertiary neurology declined by 64%, and the total number of face‐to‐face visits per month declined by 25%.ConclusionColocated neurology in a primary care medical home offers a promising intervention to deliver high‐value care.
THE GINI CONCENTRATION INDEX: A REVIEW OF THE INFERENCE LITERATURE
Authors: Giorgi Giovanni Maria , Gigliarano Chiara 
Published: December 2016

AbstractMore than a century ago, Corrado Gini proposed his well‐known concentration index for measuring the degree of inequality in the distribution of income and wealth. His index is still extremely relevant and widely used in several fields of research and application. In this paper, we focus on the inferential properties of the Gini index, and discuss the main directions of analysis proposed in the literature. The aim of the paper is to provide a comprehensive review of the main developments on the inferential aspects of the Gini concentration ratio. We feel that this work can provide a valuable contribution to those scholars who are approaching the large amount of literature on the inferential properties of the Gini index.
Effects of quercetin and surgicel for preventing adhesions after gynecological surgery: A rat uterine horn model
Authors: Güney Gürhan , Kaya Cihan , Oto Gökhan , Yıldırım Serkan , Özdemir Hülya , Tokmak Aytekin 
Published: December 2016

AbstractAimPostoperative pelvic adhesions are significant health care problems causing chronic pelvic pain, infertility and intestinal obstruction after abdominal or pelvic surgery. We investigated the effects of quercetin and Surgicel for the prevention of adhesions after gynecological surgery.MethodsA double blind, randomized, controlled experimental study was designed. Forty female Wistar Hannover rats were divided into five groups: control, sham operated, quercetin, Surgicel, and quercetin + Surgicel. The control group received medication used for the surgical procedure only. The sham group received a laparotomy only. The quercetin group received 15 mg/kg quercetin in addition to undergoing the standard surgical procedure, and the injuries in the surgical group were covered with a single, 1 cm2 layer of Surgicel (oxidized regenerated cellulose). The quercetin + Surgicel group received both 15 mg/kg quercetin and a single, 1 cm2 layer of Surgicel. Adhesions were scored 14 days after the first surgical procedure.ResultsThe extent, severity, degree, total adhesion, inflammation and fibrosis scores of the control group were significantly higher than those of the quercetin, Surgicel, and quercetin + Surgicel groups. There was no significant difference between the Surgicel and quercetin groups in degree, but all other parameters were significantly higher in the Surgicel than in the quercetin group. The quercetin + Surgicel group had lower adhesion scores than the quercetin group.ConclusionsQuercetin, Surgicel and quercetin + Surgicel treatment may be useful for preventing pelvic adhesions.
Actuarial Independence and Managerial Discretion
Authors: Kamiya Shinichi , Milidonis Andreas 
Published: December 2016

AbstractAppointed actuaries are responsible for estimating the largest liability on property–casualty insurance companies’ balance sheet. Actuarial independence is crucial in safeguarding accurate estimates, where this independence is self‐regulated by actuarial professional institutions. However, professional conflicts of interest arise when appointed actuaries also hold an officer position within the same firm, as officer actuaries also face managerial incentives. Using a sample of U.S. insurers that employ in‐house appointed actuaries from 2007 to 2014, we find evidence that officer actuaries have different reserving practices than nonofficer actuaries. This difference in reserving is associated with tax shielding and earnings management incentives. Results are consistent with managerial discretion dominating actuarial independence; they are economically significant and should be of concern to regulators and professional institutions.
Using calls as an indicator for Antarctic blue whale occurrence and distribution across the southwest Pacific and southeast Indian Oceans
Authors: Balcazar Naysa E. , Klinck Holger , Nieukirk Sharon L. , Mellinger David K. , Klinck Karolin , Dziak Robert P. , Rogers Tracey L. 
Published: December 2016

AbstractUnderstanding species distribution and behavior is essential for conservation programs of migratory species with recovering populations. The critically endangered Antarctic blue whale (Balaenoptera musculus intermedia) was heavily exploited during the whaling era. Because of their low numbers, highly migratory behavior, and occurrence in remote areas, their distribution and range are not fully understood, particularly in the southwest Pacific Ocean. This is the first Antarctic blue whale study covering the southwest Pacific Ocean region from temperate to tropical waters (32°S to 15°S). Passive acoustic data were recorded between 2010 and 2011 across the southwest Pacific (SWPO) and southeast Indian (SEIO) oceans. We detected Antarctic blue whale calls in previously undocumented SWPO locations off eastern Australia (32°S, 152°E) and within the Lau Basin (20°S, 176°W and 15°S, 173°W), and SEIO off northwest Australia (19°S, 115°E).In temperate waters, adjacent ocean basins had similar seasonal occurrence, in that calling Antarctic blue whales were present for long periods, almost year round in some areas. In northern tropical waters, calling whales were mostly present during the austral winter. Clarifying the occurrence and distribution of critically endangered species is fundamental for monitoring population recovery, marine protected area planning, and in mitigating anthropogenic threats.