bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple rules for an efficient use of Geographic Information Systems in molecular ecology
Authors: Leempoel Kevin , Duruz Solange , Rochat Estelle , Widmer Ivo , Orozco-terWengel Pablo , Joost Stéphane 
Published: March 2017

AbstractGeographic Information Systems (GIS) are becoming increasingly popular in the context of molecular ecology and conservation biology thanks to their display options efficiency, flexibility and management of geodata. Indeed, spatial data for wildlife and livestock species is becoming a trend with many researchers publishing genomic data that is specifically suitable for landscape studies. GIS uniquely reveal the possibility to overlay genetic information with environmental data and, as such, allow us to locate and analyze genetic boundaries of various plant and animal species or to study gene-environment associations (GEA). This means that, using GIS, we can potentially identify the genetic bases of species adaptation to particular geographic conditions or to climate change. However, many biologists are not familiar with the use of GIS and underlying concepts and thus experience difficulties in finding relevant information and instructions on how to use them. In this paper, we illustrate the power of free and open source GIS approaches and provide essential information for their successful application in molecular ecology. First, we introduce key concepts related to GIS than are too often overlooked in the literature, for example coordinate systems, GPS accuracy and scale. We then provide an overview of the most employed open-source GIS-related software, file formats and refer to major environmental databases. We also reconsider sampling strategies as high costs of Next Generation Sequencing (NGS) data currently diminish the number of samples that can be sequenced per location. Thereafter, we detail methods of data exploration and spatial statistics suited for the analysis of large genetic datasets. Finally, we provide suggestions to properly edit maps and to make them as comprehensive as possible, either manually or trough programming languages.
Self-stigma in military personnel with alcohol dependence: comparison with a civilian sample before qualified withdrawal treatment
Authors: Wesemann Ulrich , Kahn Christian , Zimmermann Peter Lutz , Willmund Gerd Dieter , Schomerus Georg 
Published: March 2017

Purpose
The purpose of this paper is to highlight the differences in self-stigma between a military and a civilian sample in order to infer military-specific aspects of the stigmatization process.

Design/methodology/approach
Before undergoing a three-week course of qualified withdrawal treatment, 55 German military personnel were examined in terms of self-stigma, abstinence self-efficacy, duration of alcohol abuse, severity of alcohol dependence, and current mental disorders. Afterwards, the participants were compared with a non-military sample of 173 subjects with alcohol dependence in a civilian psychiatric clinic that had not yet undergone qualified withdrawal treatment.

Findings
While awareness of stigmatization is significantly greater among military personnel than in the civilian comparison group (t(171)=3.83, p<0.01), there is far less agreement with such stigmatization (t(170)=−3.20, p<0.01). More severe mental disorders and low abstinence self-efficacy have a significant influence on self-esteem decrement for the entire group.

Research limitations/implications
Both samples only consisted of male participants who wanted to receive treatment.

Originality/value
Since most studies refer to civilian patients, a comparative study of the influence of stigmatization of alcohol use disorders in the armed forces is of particular interest. The study indicates that military personnel are more aware of stigmatization by colleagues and superiors than is the case among civilian patients. This could be a significant obstacle when it comes to seeking professional help. Prevention programs need to give greater priority to this subject.
Performance assessment of human resource by integration of HSE and ergonomics and EFQM management system
Authors: Sadegh Amalnick Mohsen , Zarrin Mansour 
Published: March 2017

Purpose
The purpose of this paper is to present an integrated framework for performance evaluation and analysis of human resource (HR) with respect to the factors of health, safety, environment and ergonomics (HSEE) management system, and also the criteria of European federation for quality management (EFQM) as one of the well-known business excellence models.

Design/methodology/approach
In this study, an intelligent algorithm based on adaptive neuro-fuzzy inference system (ANFIS) along with fuzzy data envelopment analysis (FDEA) are developed and employed to assess the performance of the company. Furthermore, the impact of the factors on the company’s performance as well as their strengths and weaknesses are identified by conducting a sensitivity analysis on the results. Similarly, a design of experiment is performed to prioritize the factors in the order of importance.

Findings
The results show that EFQM model has a far greater impact upon the company’s performance than HSEE management system. According to the obtained results, it can be argued that integration of HSEE and EFQM leads to the performance improvement in the company.

Practical implications
In current study, the required data for executing the proposed framework are collected via valid questionnaires which are filled in by the staff of an aviation industry located in Tehran, Iran.

Originality/value
Managing HR performance results in improving usability, maintainability and reliability and finally in a significant reduction in the commercial aviation accident rate. Also, study of factors affecting HR performance authorities participate in developing systems in order to help operators better manage human error. This paper for the first time presents an intelligent framework based on ANFIS, FDEA and statistical tests for HR performance assessment and analysis with the ability of handling uncertainty and vagueness existing in real world environment.
Use of failure mode effect analysis (FMEA) to improve medication management process
Authors: Jain Khushboo 
Published: March 2017

Purpose
Medication management is a complex process, at high risk of error with life threatening consequences. The focus should be on devising strategies to avoid errors and make the process self-reliable by ensuring prevention of errors and/or error detection at subsequent stages. The purpose of this paper is to use failure mode effect analysis (FMEA), a systematic proactive tool, to identify the likelihood and the causes for the process to fail at various steps and prioritise them to devise risk reduction strategies to improve patient safety.

Design/methodology/approach
The study was designed as an observational analytical study of medication management process in the inpatient area of a multi-speciality hospital in Gurgaon, Haryana, India. A team was made to study the complex process of medication management in the hospital. FMEA tool was used. Corrective actions were developed based on the prioritised failure modes which were implemented and monitored.

Findings
The percentage distribution of medication errors as per the observation made by the team was found to be maximum of transcription errors (37 per cent) followed by administration errors (29 per cent) indicating the need to identify the causes and effects of their occurrence. In all, 11 failure modes were identified out of which major five were prioritised based on the risk priority number (RPN). The process was repeated after corrective actions were taken which resulted in about 40 per cent (average) and around 60 per cent reduction in the RPN of prioritised failure modes.

Research limitations/implications
FMEA is a time consuming process and requires a multidisciplinary team which has good understanding of the process being analysed. FMEA only helps in identifying the possibilities of a process to fail, it does not eliminate them, additional efforts are required to develop action plans and implement them. Frank discussion and agreement among the team members is required not only for successfully conducing FMEA but also for implementing the corrective actions.

Practical implications
FMEA is an effective proactive risk-assessment tool and is a continuous process which can be continued in phases. The corrective actions taken resulted in reduction in RPN, subjected to further evaluation and usage by others depending on the facility type.

Originality/value
The application of the tool helped the hospital in identifying failures in medication management process, thereby prioritising and correcting them leading to improvement.
The age of Agile
Authors: Denning Stephen 
Published: March 2017

Purpose
Because too many firms are stuck on the treadmill of producing quarterly returns, often to be achieved through financial engineering, a new management mindset is needed set them to exploring new opportunities through innovation.

Design/methodology/approach
A new kind of management is emerging–called the Agile model– in which firms emphasize searching out opportunities, finding solutions through rapid experimentation, and achieving agility through decisiveness.

Findings
In organizations that have implemented the Agile model Agile, the distinction between exploration and exploitation tends to blur and even dissolve. Those involved in exploitation are also continuously looking for ways to improve performance. Those involved in exploration and development are continuously seeking ways to deliver value to customers sooner

Practical implications
Agile managements are learning to shift from scalable efficiency to scalable learning, where everyone is driven by the need to learn faster and accelerate performance improvement

Originality/value
This overview of how explains how all members of a organization–from the CEO to the front-line worker–will need to be involved in the implementation of the Agile model.
Cutaneous side‐effects of biologics in immune‐mediated disorders: A histopathological perspective
Authors: Succaria Farah , Bhawan Jag 
Published: March 2017

AbstractAdvances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side‐effects, including cutaneous, have emerged. Many times a clear‐cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. The aim of this review is to shed light on the different histopathological patterns observed as a manifestation secondary to biologics.
Mimickers of classic acantholytic diseases
Authors: Ho Jonathan , Bhawan Jag 
Published: March 2017

AbstractAcantholysis is a commonly encountered histological pattern which typically generates a differential of the pemphigus variants, Hailey–Hailey, Darier's and Grover's diseases. In addition to these diseases, the dermatologist and dermatopathologist must be aware of entities that mimic classic acantholytic dermatoses and of rare disease variants, which are characterized by acantholysis.
Non‐bullous lesions as the first manifestation of bullous pemphigoid: A retrospective analysis of 181 cases
Authors: Zhang Yu , Luo Yang , Han Yue , Tian Rong , Li Wei , Yao Xu 
Published: March 2017

AbstractThe aim of the present study was to explore the clinical and histopathological characteristics and treatment of patients with bullous pemphigoid (BP) that initially manifested as non‐bullous lesions and provide information for early diagnosis and improved treatment. Medical records of 491 cases of BP were collected. The clinical and histopathological characteristics, treatment and outcomes of patients who initially presented with non‐bullous lesions (prodromal BP, PBP) were analyzed and compared with those from patients who initially presented with bullous lesions (classical BP, cBP). Of the BP patients studied, 36.8% had PBP and presented with diversified initial lesions before the appearance of typical bullae, with erythema as the most frequent (31.67%), followed by concurrent erythema and papules (30.4%). The mean duration before bullae appearance was 15.91 ± 0.65 months. The degree of itch in PBP patients was higher than that in cBP patients. There was no difference in the hospital stay and time to disease control between the PBP and cBP patients. However, the mean glucocorticoid dose for control of the lesions in PBP patients was significantly higher than that in cBP patients. In addition, the PBP patients experienced side‐effects more frequently than did the cBP patients (87.85% vs 17.41%). In conclusion, intensive treatment is required for PBP patients due to delayed diagnosis and advanced development of the disease. Itching, concurrent erythema and papules occurring in the elderly may be clues for the early diagnosis of PBP.
Effect of Organizational Identity Change on Integration Approaches in Acquisitions: Role of Organizational Dominance
Authors: Wei Tian , Clegg Jeremy 
Published: March 2017

AbstractThe main focus of this study is the role that organizational dominance in organizational identity change plays in shaping integration approaches in acquisitions. Using four in‐depth case studies, this study categorizes the organizational identity change process into three stages: forms of resistance; conformation of new organizational identity; and integration approaches. The authors first identify two distinct roles of organizational dominance in organizational identity change after acquisition: multilevel resistance and power struggles, which are the prerequisites for developing integration approaches, according to the social identity theory. Second, they further investigate the conformation of new organizational identity with each of these two roles. They conclude that target firms completely lose their organizational identity when there is high organizational dominance after the acquisition. Conversely, target firms work with acquirers in developing integration approaches, and the power winner dominates the integration when there is low organizational dominance. Third, this study contributes to the understanding of integration approaches by connecting three specific integration approaches to the changed organizational identity. The study contributes to the literature on both organizational identity change and acquisition.
Differences between Proxy and Patient Assessments of Cancer Care Experiences and Quality Ratings
Authors: Roydhouse Jessica K. , Gutman Roee , Keating Nancy L. , Mor Vincent , Wilson Ira B. 
Published: March 2017

ObjectiveTo assess the impact of proxy survey responses on cancer care experience reports and quality ratings.Data Sources/Study SettingSecondary analysis of data from Cancer Care Outcomes Research and Surveillance (CanCORS). Recruitment occurred from 2003 to 2005.Study DesignThe study was a cross‐sectional observational study. The respondents were patients with incident colorectal or lung cancer or their proxies.Data Collection/Extraction MethodsAnalyses used linear regression models with an independent variable for proxy versus patient responses as well as study site and clinical covariates. The outcomes were experiences with medical care, nursing care, care coordination, and care quality rating. Multiple imputation was used for missing data.Principal FindingsAmong 6,471 respondents, 1,011 (16 percent) were proxies. The proportion of proxy respondents varied from 6 percent to 28 percent across study sites. Adjusted proxy scores were modestly higher for medical care experiences (+1.28 points [95 percent CI:+ 0.05 to +2.51]), but lower for nursing care (−2.81 [95 percent CI: −4.11 to −1.50]) and care coordination experiences (−2.98 [95 percent CI: −4.15 to −1.81]). There were no significant differences between adjusted patient and proxy ratings of quality.ConclusionsProxy responses have small but statistically significant differences from patient responses. However, if ratings of care are used for financial incentives, such differences could be exaggerated across practices or areas if proxy use varies.
Strata of the Political: Epigenetic and Microbial Imaginaries in Post‐Apartheid Cape Town
Authors: Pentecost Michelle , Cousins Thomas 
Published: March 2017

AbstractThe epigenetic and microbiomic imaginaries that animate public health discourse on perinatal nutrition and the infant gut in South Africa offer a case study through which to reconsider the ontological presuppositions of “space” that frame epigenetic biopolitics. We suggest that the mutual constitution of the relations at stake in and around questions of nutrition, mothers and infants, the gut and sanitation in Khayelitsha, can be understood through a Deleuzian geomorphological image of “strata of the political”. Strata are conjunctural entanglements that temporarily stabilise when distinctions hold briefly, and that bring into alignment particular relations and forces that distribute life and non‐life. This analytic makes visible and available to political life the spatio‐temporal, socio‐natural blurring of categories that epigenetic and microbiomic discourses could afford. Grounded ethnographic descriptions of these processes of “mattering” can challenge political epistemologies and take further critical perspectives on space to open up possibilities for a robust postgenomic politics.
Letter: CYP3A4/5 genotype status and outcome of vonoprazan‐containing Helicobacter pylori eradication therapy in Japan
Authors: Sugimoto M. , Ban H. , Hira D. , Kamiya T. , Otsuka T. , Inatomi O. , Bamba S. , Terada T. , Andoh A. 
Published: March 2017

Linked ContentThis article is linked to Sakurai et al and Mori and Okamoto papers. To view this article visit https://doi.org/10.1111/apt.13325.
Pro‐contractile effects of perivascular fat in health and disease
Authors: Ramirez J G , O'Malley E J , Ho W S V 
Published: March 2017

Perivascular adipose tissue (PVAT) is now recognized as an active player in vascular homeostasis. The expansion of PVAT in obesity and its possible role in vascular dysfunction have attracted much interest. In terms of the regulation of vascular tone and blood pressure, PVAT has been shown to release vasoactive mediators, for instance, angiotensin peptides, reactive oxygen species, chemokines and cytokines. The secretory profile of PVAT is altered by obesity, hypertension and other cardiovascular diseases, leading to an imbalance between its pro‐contractile and anti‐contractile effects. PVAT adipocytes represent an important source of the mediators, but infiltrating immune cells may become more important under conditions of hypoxia and inflammation. This review describes recent advances in the effects of PVAT on the regulation of vascular tone, highlighting the evidence for a pro‐contractile action in health and disease. The role of the endothelium, vascular smooth muscle, immune cells and probably perivascular nerves in PVAT function is also discussed.Linked ArticlesThis article is part of a themed section on Molecular Mechanisms Regulating Perivascular Adipose Tissue – Potential Pharmacological Targets? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.20/issuetoc
Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection
Authors: Higaki Eiji , Yanagi Shinya , Gotohda Naoto , Kinoshita Takahiro , Kuwata Takeshi , Nagino Masato , Ochiai Atsushi , Fujii Satoshi 
Published: March 2017

Outcomes of patients with gastric cancer who exhibit positive peritoneal lavage cytology findings (CY+) vary by diagnostic methods because of quantitative and qualitative cancer cell diversity. This study sought to establish practical diagnostic criteria for performing curative resections, based on peritoneal lavage cytology findings in gastric cancer patients. We enrolled 1028 patients with gastric cancer who underwent R0/1 (n = 911) or R2 (n = 117) resections and analyzed relationships between cancer cell findings in peritoneal lavage fluid and clinicopathological factors in the R0/1 group. We found 68 patients with CY+ status. Receiver operating characteristic analyses and multivariate analyses showed that the presence of ≥1 signet ring cell, ≥5 cell clusters or ≥50 isolated cancer cells in peritoneal lavage fluid predicted poor prognoses in the 68 CY+ patients. High‐risk CY+ group patients with at least one of the above predictors had the highest hazard ratio (HR = 3.28, P < 0.001). The remaining (low‐risk) patients had a survival curve similar to that of patients with a normal cytology. The high‐risk CY+ patients who underwent R1 resection had poor prognoses despite no macroscopic peritoneal metastasis (2% 5‐year survival)—equivalent to that of patients who underwent R2 resection. The CY+ criteria defined in this study could help identify candidates for curative resection as an initial therapy for gastric cancer.
Tyrosinemia type II: Mutation update, 11 novel mutations and description of 5 independent subjects with a novel founder mutation
Authors: Peña‐Quintana L. , Scherer G. , Curbelo‐Estévez M.L. , Jiménez‐Acosta F. , Hartmann B. , La Roche F. , Meavilla‐Olivas S. , Pérez‐Cerdá C. , García‐Segarra N. , Giguère Y. , Huppke P. , Mitchell G.A. , Mönch E. , Trump D. , Vianey‐Saban C. , Trimble E.R. , Vitoria‐Miñana I. , Reyes‐Suárez D. , Ramírez‐Lorenzo T. , Tugores A. 
Published: March 2017

BackgroundTyrosinemia type II, also known as Richner‐Hanhart Syndrome, is an extremely rare autosomal recessive disorder, caused by mutations in the gene encoding hepatic cytosolic tyrosine aminotransferase, leading to the accumulation of tyrosine and its metabolites which cause ocular and skin lesions, that may be accompanied by neurological manifestations, mostly intellectual disability.AimsTo update disease‐causing mutations and current clinical knowledge of the disease.Materials and MethodsGenetic and clinical information were obtained from a collection of both unreported and previously reported cases.ResultsWe report 106 families, represented by 143 individuals, carrying a total of 36 genetic variants, 11 of them not previously known to be associated with the disease. Variants include 3 large deletions, 21 non‐synonymous and 5 nonsense amino‐acid changes, 5 frameshifts and 2 splice variants. We also report 5 patients from Gran Canaria, representing the largest known group of unrelated families sharing the same P406L mutation.ConclusionsData analysis did not reveal a genotype‐phenotype correlation, but stressed the need of early diagnosis: All patients improved the oculocutaneous lesions after dietary treatment but neurological symptoms prevailed. The discovery of founder mutations in isolated populations, and the benefits of early intervention, should increase diagnostic awareness in newborns.