bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer
Authors: Song Young Shin , Lim Jung Ah , Min Hye Sook , Kim Min Joo , Choi Hoon Sung , Cho Sun Wook , Moon Jae Hoon , Yi Ka Hee , Park Do Joon , Cho Bo Youn , Park Young Joo 
Published: September 2017

ObjectiveChanges in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer (FTC) over time have not been reported. Moreover, the prognostic effects ofRASandTERTpromoter mutations in FTC have not been clearly elucidated. We investigated changes in the clinicopathological characteristics of patients with FTC over four decades, as well as the clinical significance of genetic mutations of FTC.Design and methodsThis retrospective study included 690 patients with FTC who underwent thyroidectomy between 1973 and 2015 at the Seoul National University Hospital. In 134 samples, genetic tests forN/H/KRASandTERTpromoter mutations andPAX8/PPARγrearrangement were performed.ResultsThe age at diagnosis has increased (P < 0.001) in recent decades and extrathyroidal extension of the tumor has become less common (P = 0.033). Other clinicopathological characteristics and prognosis of FTC have not significantly changed. The prevalence ofRASmutations decreased (P = 0.042) over time, whereas that ofTERTpromoter mutations remained stable.RASmutations were associated with distant metastasis and persistent disease, andTERTpromoter mutations were associated with distant metastasis, advanced TNM stage, recurrence and disease-specific mortality. FTC patients with coexistentRASandTERTpromoter mutations showed a higher recurrence risk than those with only one mutation.ConclusionsThe age at diagnosis of FTC and the frequency of extrathyroidal extension have changed over four decades. Moreover, the prevalence ofRASmutations decreased.RASandTERTpromoter mutations may be associated with poor clinical outcomes in FTC, especially when the two mutations coexist.
Intervenciones docentes en la tarea de leer para responder cuestionarios
Authors: Rosli Natalia , Carlino Paula 
Published: September 2017

Al considerar que la lectura y la escritura tienen potencialidad epistémica como instrumentos de pensamiento y desarrollo de nuevos conocimientos, este artículo focaliza la enseñanza de contenidos disciplinares con ayuda de leer y escribir en materias del nivel secundario. El objetivo principal de esta investigación fue describir y analizar las intervenciones realizadas por tres docentes argentinos en la tarea de leer para responder cuestionarios, dicha actividad es recurrente en un curso con estudiantes de sectores socioeconómicos desfavorecidos. No se han encontrado estudios que aborden prácticas de enseñanza mediadas por la lectura y la escritura en asignaturas con población de esta procedencia. En concreto, los y las estudiantes de esta escuela son trabajadores y madres y padres adolescentes que habitan en una villa. Bajo una metodología cualitativa, se diseñó un estudio de casos naturalista y se entrevistó en profundidad a los tres profesores y los catorce estudiantes. Se observaron 39 clases y se recogieron documentos. Las transcripciones de las entrevistas y las observaciones de clases se analizaron mediante estrategias de categorización y contextualización. Los resultados muestran que los profesores intervienen a través de tres funciones –definición del medio, gestión del medio y evaluación de la tarea– que comprometen a los estudiantes en la tarea, pero que escasamente indagan por sus interpretaciones acerca de lo que están leyendo. Redefinir la estructura de esta actividad, mediante la promoción en clase de usos entramados de la lectura, la escritura y el diálogo – como expresar las interpretaciones y debatir sobre ellas– ofrecería a los estudiantes posibilidades de acceder, comunicar y reflexionar sobre el conocimiento, al tiempo que colaboraría con el objetivo de equidad educativa
Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo
Authors: Mendoza-Catalán Geu , Gallegos-Cabriales Esther C. , Figueroa-Perea Juan Guillermo 
Published: September 2017

Introducción: La diabetes mellitus tipo 2 (DMT2) es un padecimiento crónico cuya incidencia se incrementa en forma alarmante. El objetivo fue identificar los factores asociados al no autocuidado en hombres con muerte prematura y diagnóstico de DMT2. Materiales y Métodos: Se realizaron seis entrevistas cualitativas a familiares de hombres con DMT2 que fallecieron por complicaciones de su enfermedad, utilizando la metodología de la autopsia verbal. Los resultados se analizaron mediante el análisis de contenido. Resultados: Dentro de los factores que surgieron como limitantes para el autocuidado fueron: la negación de la DMT2, el trabajo, el machismo, preferencia en los alimentos, apoyo familiar, el consumo de alcohol, el consumo de tabaco y la depresión. Discusión: Los hombres con DMT2 se ven influenciados por diversas circunstancias que limitan cuidarse, atenderse y por consiguiente presentar desventajas de salud, complicaciones e incluso una muerte temprana. Conclusiones: Desde la perspectiva de enfermería los resultados ayudan a comprender el comportamiento de los hombres ante esta enfermedad en donde se requiere cuidado constante, a la par que una conciencia legítima de que no se deja de ser hombre por cuidarse. Cómo citar este artículo: Mendoza-Catalán G, Gallegos-Cabriales EC, Figueroa-Perea JG. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo. Rev Cuid. 2017; 8(3): 1786-98. http://dx.doi.org/10.15649/cuidarte.v8i3.420
Negative pressure wound therapy in surgical wounds: a prospective comparative study
Authors: S. Chandrashekar , V. Veena 
Published: September 2017

Background: The goal of treating any type of wound is to promote healing in a timely fashion. Wound healing is most successful in moist, clean and warm environment. One of the most significant discoveries in wound management is the improvement of wounds with negative pressure wound therapy (NPWT). NPWT entails applying topical negative pressure to a wound. In this study, the efficacy of topical negative pressure dressing was assessed in comparison with a control group using conventional moist wound dressings in wound healing.Methods: This is a prospective comparative study conducted on 50 patients with acute, sub-acute and chronic open wounds of various aetiologies. The patients were divided into two groups each group comprising of 25 patients. One group received negative pressure wound dressing while the other group received conventional saline moistened gauze dressing. Wounds were assessed depending on wound size, appearance of granulation tissue, wound bed score, reduction in wound size along with the time taken for wound closure. Statistical analysis was done using unpaired T-test and paired T-test. A p value of <0.05 was taken as significant.Results: Present study showed that there was a statistically significant decrease in the wound size in study group, early appearance of granulation tissue, significant increase in the wound score and faster rate of wound closure compared to the control group.Conclusions: Negative pressure wound therapy can be considered as a superior option in the management of open wounds.
Endoscopic retrograde cholangio-pancreatograhy and laparoscopic cholecystectomy in single session management of acute biliary pancreatitis
Authors: Gaber Ahmed , Ammar Mohamed S. , Soltan Hatem 
Published: September 2017

Background: World widely, the annual incidence of acute pancreatitis ranges from 5 to 50 per 100000. The major cause of acute pancreatitis is biliary calculi, which occur in 50-70% of patients. Aim of this study is to evaluate Endoscopic Retrograde Cholangio-Pancreatography (ERCP) and Laparoscopic Cholecystectomy (LC) as a single step management of early acute biliary pancreatitis.Methods: A prospective study included 25 patients complaining of acute biliary pancreatitis. The study was done between December 2012 and February 2016 at Menofia University Hospital. All patients had acute biliary pancreatitis with obstructive jaundice proved by laboratory investigations and imaging. ERCP and LC in the same session were aimed in all patients. Results: Successful same session was done in 24 (96%) cases and 1 (4%) case failed (just had ERCP only). Twenty cases (80%) were females and five cases (20%) were males. By ERCP, multiple small stones were extracted in 15 (60%) cases, biliary mud in 3 (12%) cases, a big stone in 2 (8%) cases and no stones were extracted in 5 (20%) cases. During laparoscopic cholecystectomy, bile stained ascites was present in 15 (60%) cases and absent in 9 (36%) cases. Calcium soap in 7 (28%) cases and absent in 17 (68%) cases. 17 (68%) patients stayed 24 hours in hospital while 6 (24%) patients stayed 48 hours and 2 (8%) cases stayed 72 hours. No mortality was recorded.Conclusions: ERCP and LC as a single step is a good option for management of early acute biliary pancreatitis.
A prospective study on parathyroid hormone levels in detecting early hypocalcemia after total thyroidectomy
Authors: A. P. V. Sunil Kumar , G. Vinay 
Published: September 2017

Background: Hypoparathyroidism and the resultant hypocalcaemia is a major cause of postoperative morbidity after total thyroidectomy with the incidence varying from 1% to 71%. This study aims to determine the incidence of parathyroid hormone deficiency as an earliest indicator for detecting hypocalcemia following total thyroidectomy.Methods: A prospective study was carried out among 50 subjects attending Department of Surgery, K. R. Hospital, Mysuru over a period of 12 months. Subjects of either sex undergoing total thyroidectomy had their serum parathyroid hormone levels tested at 1, 4, 12 and 24 hours after surgery were included in the study. Patients with poor compliance, calcium supplementation prior to surgery, coexisting parathyroid or renal pathology were excluded from the study. Descriptive statistics and Pearson correlation coefficients were used to analyse the results.Results: Among 50 study subjects, Hypocalcemia developed in 3 subjects (6%) 24 hours after thyroidectomy showing a sensitivity, specificity, negative and positive predictive value of 91%, 100%, 98% and 96% respectively.Conclusions: Parathyroid hormone levels in postoperative total thyroidectomy is an earliest indicator to detect symptomatic hypocalcemia subjects 24 hours after surgery, which prompts early administration of oral calcium replacement therapy in high risk subjects and potential safe early discharge post-operatively.
Effect of eating frequency on prediabetes status: a self-controlled preventive trial
Authors: Dixit Jagannath V. , Indurkar Sanjiv 
Published: September 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">National diabetes data group (NDDG) first introduced the concept of a metabolic state intermediate between normal glucose homeostasis and diabetes, called glucose intolerance. The expert committee on the diagnosis and classification of diabetes mellitus extended the concept in 1997 to include patients with impaired fasting glucose (IFG) and those with impaired glucose intolerance (IGT) and referred it as prediabetes. The rationale of the study is that if a person will eat only twice in the day, the insulin secretion will be less which will reduce the fasting insulin levels which are a proxy for prediabetes status. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">This is a self-controlled preventive trial. The study was conducted from 1<sup>st</sup> July 2016 to 30<sup>th</sup> June 2017. Prediabetes was diagnosed when person had HbA1C from 5.7 to 6.4. The participants with HbA1C level from 5.7 to 6.4 were included in the study. The participants were advised to eat twice in the day and walk 4.5 km in 45 minutes every day, at least 5 days a week. They were asked to repeat HbA1C and fasting insulin after 3 months. Sample size calculated was 38. The parameters used for evaluation were HbA1C and fasting insulin.</span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">There were 33 males and 15 females in the study population. It was seen that there was significant reduction in HbA1C and fasting insulin levels of prediabetes patients. This difference was statistically significant with p value less than 0.01. All prediabetics converted to non-diabetic state in three months period. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Eating twice a day and walking 4.5 km in 45 minutes every day causes statistically significant reduction in HbA1C and fasting insulin levels in patients with prediabetes. It was seen that all 48 participants converted to non-diabetic state within a period of 3 months</span>.</p>
A study to find out the effect of remote ischemic post conditioning of lower limb in patients of acute myocardial infarction undergoing primary percutaneous coronary intervention
Authors: R. Sreedhara , Tripathi Vishwa Deepak 
Published: September 2017

Background: Reperfusion therapy of affected myocardium is among the most successful method for infarct size reduction and achieving the better outcome in patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (pPCI) is among best procedures for successful reperfusion therapy which has effect in reduction of size of infarct, maintaining ventricular function for better outcome. In this study, authors were aimed to assess whether remote ischemic post-conditioning (RIPC) of lower limb could reduce enzymatic infarct size in patients with acute STEMI undergoing pPCI.Methods: A case control, cross sectional, hospital based randomized study was carried out in Institute of Cardiovascular Sciences, IPGMER, Kolkata, from February 2014 to October 2015. Total 40 patients (20 cases and 20 controls) who were undergoing primary PCI for acute myocardial infarction were taken for study. In the active treatment group, the protocol was started with thrombectomy. The lower limb was exposed to 3 cycles of ischemia/reperfusion, each obtained by 5 min cuff inflation at 200mmHg, followed by 5 min complete deflation. End point of the study will be enzymatic infarct size assessed by the area under the curve of creatine kinase-myocardial band (CK-MB) release.Results: The AUC of serum CK release during the first 72 hours of reperfusion was significantly reduced (p=0.0341) in the post-conditioned group compared with the control group, averaging 9632 units in postconditioned compared with 13493 units in control group which represented 26% of reduction of infarct size.Conclusions: Remote ischemic post conditioning of lower limb significantly improves blush grading and enzymatic infarct size reduction with a trend towards significant reduction of mean ST segment deviation.
Antibiotic susceptibility pattern of organisms in chronic rhinosinusitis
Authors: Singh Namit Kant , Garg Lakshmi Narayan , Baisakhiya Nitish , Kuhar Hitesh , Shekhar Shubhranshu , Rao Naiya , Singh Anshul 
Published: September 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Chronic rhinosinusitis is an ever increasing problem faced by all sectors of the population throughout the world. Various etiologic factors have been associated with the disease entity but the main concern throughout the world is the increasing antimicrobial resistance which is leading to less compliance and higher treatment cost. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A total of 60 cases and 60 controls were selected and nasal swabs were collected under endoscopic guidance from middle meatus and were sent for culture and sensitivity. </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">The data collected showed that the most common pathogen isolated from the cases was <a name="_Hlk489995419"></a>methicillin resistant <em>Staphylococcus aureus</em> (MRSA) accounting for 58.33% followed by fungi and methicillin susceptible <em>Staphylococcus aureus</em> (MSSA). The antibiotic sensitivity showed that MRSA is having the most resistant pattern with only Vancomycin, Teicoplanin and Linezolid having 100% sensitivity followed by Rifampicin, Netilmicin and Clindamycin. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">From this study we conclude that MRSA is the most common pathogen affecting the cases of chronic sinusitis and it shows a high degree of resistance towards antibiotics which is responsible for incurring higher cost of treatment and low compliance.</span></p>
The Effect Of Internal Capital Market Of Korean Large Business Groups On Investment Efficiency
Authors: Lee Minwoo , Choi Yuwon , Moon Sanghyuk 
Published: September 2017

This study examines whether the effect of funding through internal capital markets on investment efficiency is differentiated by the incentives of controlling shareholders as measured by the divergence between cash flow rights and voting rights of controlling shareholders (hereafter, wedge).
To empirically analyze hypotheses of this study, 1,189 firm-year observations were collected from Korean firms listed on the Korea Composite Stock Price Index (KOSPI) belonging to a large business group designated by the Korea Fair Trade Commission over the period from 2005 to 2012. The results of the analysis are as follows.
First, we find that the magnitude of internal funding, as measured by total payables to the related parties, is positively (+) associated with investment inefficiency. Second, the interaction variables of total payables to the related parties and the wedge have a significant positive (+) effect on investment inefficiency. In other words, the deterioration of investment efficiency due to the increase in total payables to the related parties was mainly caused by firms with a big wedge. This result suggests that the effect of internal capital markets on investment efficiency of large business groups may be differentiated by the wedge that is proxy of the controlling shareholder’s incentive.
This study provides additional evidence on previous studies on the investment efficiency of large business groups by considering both the internal capital market and incentives for funding using the internal capital market, which are important factors affecting the investment of large corporate groups. Also, the results of this study are expected to provide implications for the regulatory policy of large business groups which have recently become an issue in Korea.
The Effect Of Affiliate Loan Guarantees On Cost Of Debt: Evidence From Korea
Authors: Woo Yong-Sang 
Published: September 2017

A loan guarantee occurs when a company guarantees payment of an affiliate’s loan. Conflicting arguments regarding loan guarantees provided to affiliates have prevailed. First, some suggest that loan guarantees provided to affiliates would decrease firm value because they are contingent liabilities (Shim, 1996; Berkman, Cole & Fu, 2009). Second, others suggest firm value is high when the amount of loan guarantees provided to affiliates is large because loan guarantees would be regarded as a positive indicator of future cash flow (Lee, 2005). The purpose of this study was to present additional empirical evidence of these arguments.
The result of this study showed that cost of debt is high when the amount of loan guarantees provided to affiliates is large. This result indicates that creditors demand higher risk premiums when the amount of loan guarantees provided to affiliates is large because they regard loan guarantees as contingent liabilities. Therefore, this result supports the assertion that loan guarantees decrease firm value.
Nature Of Information Provided And Quality Of Sustainability Reports Assurance Statements Of Fortune Global 500 Companies
Authors: Achmad Tarmizi , Faisal Faisal , Ulum Muhammad Bahrul 
Published: September 2017

The objective of this study is to investigate how the quality of assurance statement varies among the different assurance providers (accounting versus non-accounting firms). The sample consists of one hundred thirty-five of Fortune Global 500 companies for the year 2014. Independent sample t-test is used to determine how the quality of assurance statement differs among various assurance providers.
The result shows that accounting firms still dominate the sustainability report assurance market (75.56 per cent), while non-accounting firms is 24.44 per cent. However, in terms of quality score of assurance statement, non-accounting assurance providers (consultant) value higher than accounting firms for all aspects of report content (reporting format, assurance procedures and recommendations and opinion).
The implication of this finding suggests that the company not only to consider the reputation of the assurance provider, but the more important thing is competence and expertise in the field of sustainability reporting. Despite the growing interest research in assurance, this study is one of the few studies that measure assurance quality by content analysis.
The Effects Of Business Strategy On The Association Between R&D Expenditure And Future Firm Performance
Authors: Chung Anjung , Choi Manseek 
Published: September 2017

Research and Development (R&D) expenditure is one of the most essential factors for firm’s sustainable growth. Business strategy describes long-term business planning of a company, and chosen business strategy will have a significant impact on the financial status and performance of a firm. This study examines whether the business strategy affects the association between R&D and firm performance, defined as earnings persistence, earnings growth, and firm value. Like Jermias (2008), product differentiation and cost leadership strategies are classified by the cluster analysis using three ratios: R&D intensity, asset turnover, and profit margin ratio.
Our findings are as follows. (1) the effect of R&D expenditure on earnings persistence according to the business strategy appeared to be almost insignificant. (2) the effects of R&D expenditure on earnings growth up to three consecutive years are stronger in firms with product differentiation strategy than in firms with cost leadership strategy. These results indicate that R&D are more important and have greater impacts on future performance for product differentiation firms than for cost leadership firms. (3) R&D expenditure of product differentiation firms are more closely related to the firm value than R&D expenditure of cost leadership firms. The results of this study will be useful to practitioners when they are making R&D-related decisions based on their business planning. Also, this study provides useful empirical results to financial analysts and accounting academics when they are analyzing profitability and firm value.