bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Stratification in Twin Pregnancies Complicated by GDM
Authors: Catic Anja , Heinzl Florian , Göbl Christian , Yerlikaya-Schatten Gülen , Reischer Theresa 
Published: September 2024

Aims: This study was aimed at assessing the association of oral glucose tolerance test (OGTT) glucose threshold levels and the requirement of insulin therapy in twin pregnancies with gestational diabetes mellitus (GDM).Methods: In this post hoc analysis of a cohort study spanning 18 years, 446 patients with twin pregnancy and GDM (246 managed with lifestyle modification and 200 requiring pharmacotherapy) were included. We collected and evaluated maternal characteristics, as well as fasting, 1‐h, and 2‐h glucose concentrations from a standardized 75‐g OGTT. The assessment methods included logistic regression analysis, positive and negative predictive values, area under the curve (AUC), and random forest analysis.Results: The fasting (p < 0.01, OR: 1.03 [95% CI 1.01–1.05]) and 1‐h (p < 0.01; OR: 1.01 [95% CI 1.00–1.02]) glucose levels during the OGTT were significantly associated with the subsequent need for insulin therapy, with thresholds of 95 mg/dL for fasting glucose and 184 mg/dL for the 1‐h OGTT. Additionally, indications for insulin therapy were marked by thresholds of 108 mg/dL at G0, 215 mg/dL at G60, and 86 mg/dL at G120.Conclusion: Identifying threshold values for insulin therapy and risk stratification in twin pregnancy are crucial for optimal patient management.
Abstract A002: HPV Vaccination Disparities by Gender Identity Among Adults Aged 18–44-Year-Olds
Authors: Lee Minjee , Tsai Meng-Han 
Published: September 2024

Abstract
Background: In the U.S., human papillomavirus (HPV) vaccination has been recommended for individuals up to age 26, although it is currently approved for people up to age 45. While lower rates of vaccination are expected for adults between the ages of 27 and 45, there is limited research examining vaccination rates among this age cohort across all gender subgroups. This research aimed to explore HPV vaccination status, with subgroup analyses by gender identity, sexual orientation, and sociodemographic/access to care factors that may serve as barriers to or facilitators of vaccination. Methods: This study utilized data from the 2019-2022 Behavioral Risk Factor Surveillance System. The analytic sample included individuals who reported their gender identity, sexual orientation, and HPV vaccination status. Weighted, multivariable logistic regression was used to identify factors associated with vaccination initiation and completion. Results: The 17,382 individuals aged 18-44 years included 8,134 cismales, 9,164 cisfemales, 37 transmales, and 47 transfemales. Vaccination initiation and completion rates were low, at 24.2% and 9.5%, respectively, and varied by gender identity: cismales (15.7%/4.1%), cisfemales (29.6%/12.6%), transmales (37.7%/17.9%), and transfemales (40.2%/8.8%) (P &lt; .0001). In weighted multivariable models, cismales were significantly less likely than cisfemales to initiate (OR: 0.40; 95% CI: 0.34-0.47) and complete (OR: 0.26; 95% CI: 0.21-0.33) vaccination. However, no significant differences were observed for transmales and transfemales compared to cismales. Factors associated with lower initiation included older age, non-Hispanic Black race, being married, having a high school diploma, rural residence, lack of insurance, and no regular healthcare provider. Factors associated with lower completion included older age, non-Hispanic Black race, being married, having a high school diploma, and no regular healthcare provider. Conclusion: HPV vaccination rates in the U.S. are low across all gender subgroups. Understanding vaccination disparities, particularly those related to gender identity, as well as identifying vaccination facilitators and barriers, is crucial for informing policy and program efforts, especially for adults between the ages of 27 and 45 who were excluded from the initial vaccination recommendations.
Citation Format: Minjee Lee, Meng-Han Tsai. HPV Vaccination Disparities by Gender Identity Among Adults Aged 18–44-Year-Olds [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A002.
Abstract A007: Beyond continental ancestry categories: trans-population genomic similarity continuum reveals overlooked somatic-germline interactions across cancer types
Authors: Mohsen Hussein , Perea-Chamblee Tomin , Carrot-Zhang Jian 
Published: September 2024

Abstract
A growing body of research highlighted a strong presence of continuums that describe human genomic diversity. Historical scholarship has also extensively investigated the use of discrete classification systems in human genomics further questioning their validity. To investigate the limiting effect of pre-defined stratification, we performed a wide comparative driver GWAS analysis at the trans-population (i.e. without stratification) vs continent-based population levels across 16 cancer types. Results demonstrate that in the MSK-IMPACT cohort (n = 56,826 samples), the analysis of the trans-population genomic similarity continuum captures significant somatic-germline interactions (p &lt; 5x10-8) in cancer type-specific and pancancer cohorts, with a set of interactions overlooked by the discrete continent-based paradigm. We demonstrate that overlooked germline SNPs have similar allele frequencies and directional relationships with somatic alterations across pre-defined discrete categories, and that earlier stratification prevents their detection due to lowered statistical power. PheWAS analysis of detected germline variants revealed associations with cancer and non-cancer phenotypes reported in previous studies as well as novel hits. To expand the scope of the trans-population lens, we carried out a comparative analysis on 17 whole-exome TCGA cohorts to identify potential cancer drivers based on mutational frequencies. Results similarly revealed known and potential cancer drivers at the trans-population level that would be overlooked when pre-defined continent-based stratification is applied. The lens we adopt further highlights the necessity for new quantitative perspectives to comprehensively detect genomic patterns and to leverage entire genomic datasets without pre-defined stratification schemes.
Citation Format: Hussein Mohsen, Tomin Perea-Chamblee, Jian Carrot-Zhang. Beyond continental ancestry categories: trans-population genomic similarity continuum reveals overlooked somatic-germline interactions across cancer types [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A007.
Abstract A016: Understanding the Impact of Numerous Cancer Prevention Guidelines on Public Adherence
Authors: Nzeako Tochukwu , Chido-Amajuoyi Onyema 
Published: September 2024

Abstract
Background: Organizations like the American Cancer Society (ACS) and the U.S. Preventive Services Task Force (USPSTF) have developed comprehensive cancer prevention guidelines focusing on nutrition, physical activity, cancer screening, and vaccination with a goal of reducing cancer incidence and improving cancer health outcomes. However, the abundance and complexity of these guidelines can lead to public confusion and potentially hinder adherence. This study investigates public perception of the multitude of cancer prevention guidelines and their potential impact on compliance. Methods: Data were derived from the 2020 Health Information National Trends Survey (HINTS 5, Cycle 4, 2020), conducted via a mail survey from February to June 2020. We examined public perception about cancer prevention recommendations and if the number of recommendations made it more difficult to determine which ones to follow. Multivariable Logistic regression was used to examine the factors that are associated with agreement with the statement: “there are so many different recommendations about preventing cancer, it's hard to know which ones to follow.” Results: Survey respondents consisted of 3,747 U.S. adults. Approximately 74.1% of respondents agreed with the statement, "There are so many different recommendations about preventing cancer, it's hard to know which ones to follow." Non-Hispanic Black respondents had the highest proportion of agreement (80.6%) Level of education was statistically significantly associated with agreement with the statement "there are so many different recommendations about preventing cancer, it's hard to know which ones to follow." As education level increased, the odds of agreeing with the statement decreased. Specifically, college graduates (aOR 0.58; 95% CI: 0.36-0.94), and those with postgraduate education had an aOR of 0.38 (95% CI: 0.22-0.67). Conclusion: The study highlights significant public perception challenges regarding the abundance of cancer prevention guidelines. These findings suggest a need for streamlined communication and education strategies to enhance guideline adherence and optimize cancer prevention efforts.
Citation Format: Tochukwu Nzeako, Onyema Chido-Amajuoyi. Understanding the Impact of Numerous Cancer Prevention Guidelines on Public Adherence [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A016.
Abstract A023: Immune-related diseases and skin cancer in a racially and ethnically diverse US-based population
Authors: Lin Erica M. , Ragi Sara , Lim Rachel , Lin Shirley , Moseley Isabelle , Qureshi Abrar , Cho Eunyoung 
Published: September 2024

Abstract
Though the immune system plays a crucial role in skin cancer development, associations between immune-related diseases and skin cancer have not been well studied in racial and ethnic minorities. The goal of this cross-sectional study was to assess the relationship between various immune-related diseases and basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and cutaneous malignant melanoma (MM) diagnoses within the diverse “All of Us” Research Program cohort. It included 307,451 adult participants with electronic health record (EHR) data enrolled from 2017-2023. Participant EHRs were used to determine immune-related diseases and skin cancer diagnoses. Multivariate logistic regression analyses were adjusted for demographic characteristics, lifestyle factors such as smoking history, in addition to health insurance status, educational attainment, history of photosensitivity, history of organ transplant, as well as UV exposure at residence. R v4.0.5 was utilized to conduct the analysis. 8,107 participants with BCC, 4,102 with SCC and 2,461 with MM were identified. Personal history of any immune-related disease was significantly associated with all skin cancer types (odds ratio and 95% confidence intervals -- BCC: 1.27 [1.20-1.33]; SCC:1.38 [1.29-1.49]; MM: 1.55 [1.42-1.69]). Rheumatoid arthritis, hypothyroidism, type I diabetes, Crohn’s disease, and ulcerative colitis were each associated with the three skin cancer types. Multiple sclerosis, Sjogren’s syndrome, hyperthyroidism, dermatomyositis/polymyositis, vitiligo, and psoriasis were associated with at least one skin cancer. Systemic lupus, scleroderma, alopecia areata, and atopic dermatitis were not associated with any skin cancer. In non-White participants alone (n=133,144; 43.3%), history of any immune-related disease was similarly significantly associated with all three skin cancer types. These findings suggest that the history of several immune-related diseases is associated with skin cancer, including among racial/ethnic minorities, and thus increased skin cancer surveillance in these patient populations may be indicated.
Citation Format: Erica M. Lin, Sara Ragi, Rachel Lim, Shirley Lin, Isabelle Moseley, Abrar Qureshi, Eunyoung Cho. Immune-related diseases and skin cancer in a racially and ethnically diverse US-based population [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A023.
Abstract A034: DNA repair capacity in metastatic castration-resistant prostate cancer patients using lymphocytes as surrogate markers
Authors: Matta Jaime , Encarnación-Medina Jarline , Ruiz-Deya Gilberto , Rodriguez-Baez Valerie , Ortiz-Sanchez Carmen 
Published: September 2024

Abstract
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men from the United States (US) and Puerto Rico (PR). In 2024, around 35,250 PCa-related deaths will occur in the US, making PCa the second leading cause of cancer-related mortality in men in the US. In Puerto Rican men, PCa represents the first cause of cancer incidence (38%) and mortality (19%). Metastatic castrate-resistant prostate cancer (mCRPC) remains among the most frequent causes of cancer-related mortality in males. Patients with mCRPC become progressively resistant to androgen deprivation therapy, and the median survival for these patients is around two years. Ortiz-Sanchez et al. (2022) previously reported that the nucleotide excision repair (NER) pathway is dysregulated in the lymphocytes from patients with indolent and aggressive PCa; nevertheless, mCRPC cases were not included in the study design. Therefore, this pilot study aimed to evaluate the DNA repair capacity (DRC) in Puerto Rican men with and without mCRPC through the CometChip assay using lymphocytes as surrogate markers. Variations in mean DRC values were expected among the study groups. DRC measurements through the NER pathway were performed in a cohort of 96 participants, including PCa cases (n=71) and controls (n=25). The mean DRC value for the control group was 17.63%, and for the cases, it was 7.90%. When comparing mCRPC (n=16), non-mCRPC (n=55), and controls, significant differences were observed between the controls and each cancer group. However, no significant differences were found between PCa cases stratified by disease aggressiveness. Currently, we are evaluating the functionality of the homologous recombination repair pathway to gain additional insights into the role of DRC in PCa. Our results represent the first effort to apply a phenotypic assay to evaluate the overall DRC in mCRPC. This may improve patient diagnosis and patient stratification in terms of disease progression.
Citation Format: Jaime Matta, Jarline Encarnación-Medina, Gilberto Ruiz-Deya, Valerie Rodriguez-Baez, Carmen Ortiz-Sanchez. DNA repair capacity in metastatic castration-resistant prostate cancer patients using lymphocytes as surrogate markers [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A034.
Abstract A035: Protein quantitative trait loci analysis in diverse prostate cancer patients: A focus on angiogenesis
Authors: Casiano Ashlie Santaliz , Schaumloffel Hunter , Liu Huaitian , Jenkins-Lord Brittany , Minas Tsion , Dorsey Tiffany , Ambs Stefan 
Published: September 2024

Abstract
Prostate cancer exhibits notable disparities in mortality rates between African American (AA) and European American (EA) populations, with genetic ancestry and the social environment influencing both disease risk and lethality. Angiogenesis, the process of new blood vessel formation, plays a critical role in tumor progression and metastasis. However, the germline genetic contribution to the physiological variation in levels of circulating angiogenic markers, and the angiogenic process, is largely unknown. This study aims to explore the genetic underpinnings of angiogenesis in prostate cancer patients through a protein quantitative trait loci (pQTL) analysis. We analyzed 30 blood-based angiogenesis-related immuno-oncology markers in a cohort of 2,437 men from Ghana and the United States, comprising 1,330 controls and 1,107 prostate cancer cases. A comprehensive evaluation of 4,301,332 single nucleotide polymorphisms (SNPs) was conducted to investigate their associations with these markers across 3 population groups (Ghanaian, African American, and European American men). In this genome-wide pQTL we identified loci that associated with the levels of 13 markers (p &lt;1.2 x 10-9). Our findings reveal that germline genetic variants may contribute to the variability in circulating angiogenic marker levels, or the systemic angiogenesis-inducing potential, with specific loci showing population-specific associations. We further link these circulating angiogenic markers to prostate cancer disease characteristics. Thus, our results suggest that germline genetic factors influence circulating levels of circulating angiogenesis-related proteins and thereby systemic angiogenesis, with a relationship to prostate cancer.
Citation Format: Ashlie Santaliz Casiano, Hunter Schaumloffel, Huaitian Liu, Brittany Jenkins-Lord, Tsion Minas, Tiffany Dorsey, Stefan Ambs. Protein quantitative trait loci analysis in diverse prostate cancer patients: A focus on angiogenesis [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A035.
Abstract A042: Patient poverty burden influences the molecular biology of ER+ breast cancer
Authors: DeWitt Jerry T. 
Published: September 2024

Abstract
Although the incidence of estrogen receptor positive (ER+) breast cancer is similar for Black and White women in the US, Black patients have significantly worse outcomes. Black women in the US have also have worse health care options, poorer educational opportunities, and face significantly higher rates of poverty burden. Collectively contributing to an overall lower socioeconomic status (SES) compared to White women. However, cancer health disparities research primarily exists in two forms: 1) The impact of socioeconomic factors on cancer outcomes, and 2) The molecular underpinnings associated with genetic ancestry on cancer biology. This siloing results in an incomplete picture of how systemic factors (i.e. racism, poverty burden) contribute to the biology of breast cancer in addition to, and along-with, ancestral genetics. Consequently, differences in the molecular biology between tumors from Black and White women remains a gap in knowledge in the field, because ancestral genetics cannot explain the breadth of disparities that patients face. Recent studies have found that Black cancer patients have a unique gene expression profile that may modulate treatment response. For instance, ER+ breast tumors in Black women have distinct signatures of defective DNA damage repair (DDR) that associate with more aggressive tumor growth. However, how factors of SES contribute to these differences in molecular biology and whether these differences alter treatment response remain unknown. One challenge to addressing these questions is that existing datasets significantly underrepresent Black women and are not sufficiently annotated to understand the complex interplay between molecular biology and factors of SES. Here, we present analysis of RNA expression datasets from 60 ER+ patient tumors (38 Black, 22 White), with corresponding SES and patient outcome annotations. Altogether, these data begin to define the complex interplay between factors of SES and changes in gene expression in addition to patient outcomes for women with ER+ breast cancer.
Citation Format: Jerry T. DeWitt. Patient poverty burden influences the molecular biology of ER+ breast cancer [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A042.
Abstract A064: Patient-provider trust and immigration experiences and h. pylori knowledge among Asian Americans
Authors: Liu Zhiqing E. , Kai-Chun Fu Jerry , Lu Wenyue , Do Phuong , Zhou Kathy , Kim Ellen , Tan Yin , Zhu Lin , Ma Grace X. 
Published: September 2024

Abstract
Background: Asian Americans experience a disproportionately higher prevalence of Helicobacter pylori (H. pylori) infection. However, there persists limited awareness about H. pylori infection and the associated factors among this population. Methods: To assess the level of H. pylori-related knowledge and its association with immigration and provider-related factors, we conducted a cross-sectional pilot study involving 131 Asian American individuals aged 30-75 in the greater Philadelphia and NYC areas. Participants administered a questionnaire covering topics including migration experiences, provider characteristics, medical encounters, and other relevant covariates. Poisson regression was used to evaluate the relationship between these factors and H. pylori knowledge scores. Results: Among all participants, 78% (102/131) were not racially concordant with their PCP, and 39% (51/131) had limited English proficiency. Vietnamese participants had the highest mean H. pylori knowledge score (10.8, SD: 1.4), followed by Chinese (7.2, SD: 4.7) and Korean (5.7, SD: 4.4). In the crude model, racial concordance with PCPs showed a positive relationship (IRR: 1.33, 95% CI: 1.14–1.56) with knowledge scores, while length of immigration demonstrated a weak negative relationship (IRR: 0.98, 95% CI: 0.97–0.99). In the adjusted model, personal health experiences (aIRR: 1.3, 95% CI: 1.10–1.54) and patient-provider communication (aIRR: 1.71, 95% CI: 1.43–2.06) as key determinants of H. pylori knowledge. Conclusion: H. pylori knowledge in Asian Americans is influenced by immigration experiences and the trust between patients and providers, which affects information exchange, medical comprehension, and treatment adherence. Therefore, interventions aimed at improving H. pylori knowledge within the Asian American community should prioritize fostering trust between patients and their healthcare providers. This trust serves as a crucial foundation for facilitating informed decision-making and implementing preventive measures against gastric cancer.
Citation Format: Zhiqing E. Liu, Jerry Kai-Chun Fu, Wenyue Lu, Phuong Do, Kathy Zhou, Ellen Kim, Yin Tan, Lin Zhu, Grace X. Ma. Patient-provider trust and immigration experiences and h. pylori knowledge among Asian Americans [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A064.