bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between birthweight and preterm birth and the ages at menarche and menopause
Authors: Daniele Christian , Wacks Rachel E. , Farland Leslie V. , Manson JoAnn E. , Qi Lihong , Shadyab Aladdin H. , Wassertheil-Smoller Sylvia , Spracklen Cassandra N. 
Published: October 2024

Abstract
Background
Women who reach menarche and menopause at earlier ages have been shown to be at increased risk for numerous conditions including cardiovascular disease, cancer, depression, and obesity; however, risk factors for earlier ages of menarche and menopause are not fully understood. Therefore, we aimed to perform a retrospective investigation of the associations between a personal birthweight and/or being born preterm and the age of and menarche and menopause and related events in the Women’s Health Initiative, a large, racially and ethnically diverse cohort of postmenopausal women.

Methods
At study entry, women reported their birthweight by category (< 6 lbs., 6–7 lbs. 15 oz, 8–9 lbs. 15 oz, or ≥ 10 lbs.) and preterm birth status (4 or more weeks premature). Ages at events related to menarche and menopause were also self-reported. Linear regression and logistic regression models were used to estimate unadjusted and adjusted effect estimates (β) and odds ratios (OR), respectively (n ≤ 86,857). Individuals born preterm were excluded from all birthweight analyses.

Results
After adjustments, individuals born weighing < 6lbs. were more likely to reach natural menopause at an earlier age (adjusted β=-0.361, SE = 0.09, P = < 0.001) and have a shorter reproductive window (adjusted β = -0.287, SE = 0.10, p < 0.004) compared to individuals weighing 6–7 lbs. 15 oz. Individuals born preterm were also more likely to reach natural menopause at an earlier age (adjusted β=-0.506, SE = 0.16, P = 0.001) and have a shorter reproductive window (adjusted β = -0.418, SE = 0.17, p < 0.006).

Conclusions
These findings raise concerns that, as more preterm and low birthweight individuals survive to adulthood, the prevalence of earlier-onset menarche and menopause may increase. Clinical counseling and interventions aimed at reducing the incidence of preterm and low birthweight births, as well as intensification of lifestyle modifications to reduce CVD risk among women with these early-life risk factors, should be prioritized.
Schistosoma japonicum infection-mediated downregulation of lncRNA Malat1 contributes to schistosomiasis hepatic fibrosis by the Malat1/miR-96/Smad7 pathway
Authors: Jiang Pengyue , Ye Shengyu , Fan Xiaobin , Tian Yini , Zhang Dongmei , Pan Weiqing 
Published: October 2024

Abstract
Background
Schistosoma japonicum infection causes hepatic fibrosis, a primary cause of morbidity and mortality associated with the disease, and effective treatments are still lacking. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenic process of various tissue fibroses. However, the role of lncRNAs in schistosomiasis hepatic fibrosis (HF) is poorly understood. Understanding the role of lncRNAs in schistosomiasis HF will enhance knowledge of disease processes and aid in the discovery of therapeutic targets and diagnostic biomarkers.

Methods
Differentially expressed lncRNA profiles in primary hepatic stellate cells (HSCs) of mice infected with S. japonicum were identified using high-throughput lncRNA sequencing. Primary HSCs were isolated from infected mice using collagenase digestion and density-gradient centrifugation, cultured in DMEM with 10% fetal bovine serum. Dual-luciferase reporter assays, nuclear cytoplasm fractionation and RIP assays were employed to assess the relationship between Malat1 and miRNA-96. Malat1 lentivirus and ASO-Malat1 were constructed for forced expression and downregulated expression of Malat1. The Malat1-KO mouse was constructed by CRISPR/Cas9 technology. Pathological features of the liver were evaluated by hematoxylin-eosin (HE), Masson’s trichrome staining and immunohistochemistry (IHC). The expression levels of fibrosis-related genes were determined by quantitative real-time PCR (qRT-PCR) and Western blot.

Results
A total of 1561 differentially expressed lncRNAs were identified between infected and uninfected primary HSCs. Among the top altered lncRNAs, the downregulated Malat1 was observed in infected HSCs and verified by qPCR. Treatment of infected mice with praziquantel (PZQ) significantly increased the Malat1 expression. Elevated Malat1 expression in infected primary HSC reduced the expressions of profibrogenic genes, whereas Malat1 knockdown had the opposite effect. Moreover, Malat1 was found to interact with miR-96, a profibrotic miRNA, by targeting Smad7. Forced Malat1 expression reduced miR-96 levels in infected primary HSCs, attenuating fibrogenesis and showing negative correlation between Malat1 expression and the expression levels of miR-96 and profibrogenic genes α-SMA and Col1α1. Notably, in Malat1-KO mice, knockout of Malat1 aggravates schistosomiasis HF, while restored Malat1 expression in the infected HSCs reduced the expression of profibrogenic genes.

Conclusions
We demonstrate that lncRNA is involved in regulation of schistosomiasis HF. Elevated lncRNA Malat1 expression in infected HSCs reduces fibrosis via the Malat1/miR-96/Smad7 pathway, thus providing a novel therapeutic target for schistosomiasis HF. Furthermore, Malat1 expression is sensitive to PZQ treatment, thus offering a potential biomarker for assessing the response to chemotherapy.

Graphical abstract
Key challenges in prehospital and emergency care in Indonesia and Malaysia: a survey of frontline clinicians
Authors: Tokita Akio , Nunokawa Hanako , Liu Keibun , Iwamoto Yuta , Sonoo Tomohiro , Hara Konan , Nakajima Mikio , Fukaguchi Kiyomitsu , Takeda Takanori , Sanip Amirudin , Juzar Dafsah A. , Gurjeet Singh a/l Harvendhar Singh , Condro Lukito , Tobing Monalisa , Abu Hasan Muhammad Abdus-Syakur bin , Nik Abdul Rahman Nik Hisamuddin , Mahisa Orizanov , Aviesena Zairinal Ramdinal , Ramli Mohd Khairulizwan bin , Mohd Nor Mohd Afiq , Goto Tadahiro , Zakaria Mohd Idzwan bin 
Published: October 2024

AbstractRapid economic growth in Indonesia and Malaysia has widened the gap in emergency care supply and demand, intensifying challenges. Our study, from August to November 2022, assesses current diverse challenges in both countries' emergency care systems from frontline staff perspectives. The online survey involved emergency department (ED) personnel from 11 hospitals in Indonesia and Malaysia, drawing from an existing network. The survey collected data on respondents’ characteristics, factors affecting prehospital and ED care quality, missing clinical information, and factors influencing patients’ ED stay duration. With 83 respondents from Indonesia and 109 from Malaysia, the study identified common challenges. In both countries, inadequate clinical information from ambulances posed a primary challenge in prehospital care quality, while crowdedness during night shifts affected ED care quality. Frequent gaps in essential clinical information, such as family and medication history, were observed. Prolonged ED stays were associated with diagnostic studies and their turnaround time. This study offers insights into shared challenges in Indonesia and Malaysia's emergency care systems. Our findings stress recognizing common and country-specific challenges for enhanced emergency care quality in Southeast Asia, supporting tailored interventions.
Women’s entrepreneurial journey in developed and developing countries: a bibliometric review
Authors: Vuciterna Rina , Ruggeri Giordano , Mazzocchi Chiara , Manzella Sara , Corsi Stefano 
Published: October 2024

AbstractThis paper presents a comprehensive bibliometric review of the scientific literature on women’s entrepreneurship in agriculture across developed and developing countries. The paper delineates the evolving landscape, challenges, and opportunities that shape women’s entrepreneurship experiences in agriculture in the contexts of developed and developing countries. Through a detailed bibliometric analysis of 728 papers from 1992 to 2022, employing performance analysis and science mapping, our methodology distinguishes itself by quantifying contributions and mapping the thematic evolution within this domain. Our study reveals the significant contributions of women entrepreneurs to agricultural innovation, sustainability, and rural development while facing systemic biases, limited access to resources, and societal stereotypes that hinder their entrepreneurial path. The paper underscores the disparity in women’s entrepreneurship between developed and developing regions, with developed countries showcasing lower participation rates in agricultural entrepreneurship but a higher presence in decision-making roles within agribusinesses.In contrast, developing countries display a higher engagement of women in entrepreneurship, driven by necessity and marked by significant contributions to food security and economic stability, though under challenging conditions. Notably, the paper highlights the underrepresentation of women’s agricultural endeavours in scholarly research, pointing to a gap in the documentation and understanding of their contributions. The study reveals emerging themes such as digital agriculture, climate resilience, sustainability, and innovation, pointing towards future research directions that could further empower women in agriculture. It calls for more inclusive research and policy-making to recognise and support women’s vital role in agriculture, advocating for a holistic approach to address women entrepreneurs’ challenges in different economic contexts. Through this analysis, the paper contributes to a deeper understanding of gender dynamics in agricultural entrepreneurship and suggests pathways for fostering more equitable and sustainable agricultural practices.
Experiences and support needs of psychiatrists under investigation
Authors: Kongara Swapna , Tamworth Millie , Gibbons Rachel 
Published: October 2024

Aims and method
This study aimed to explore the experiences and support requirements of psychiatrists undergoing investigations within their mental health organisation. An anonymous online survey was distributed to all non-training psychiatrists registered as members of the Royal College of Psychiatrists.

Results
Of the 815 psychiatrists who responded to the survey, 287 (35%) had been investigated. The majority (76%) were unaware of the concerns before being notified, 36% lacked understanding and 62% experienced timeline deviations. Furthermore, 34% had concerns over conflicts of interest, with 52% perceiving the investigation as unfair, 62% were not informed of their rights. Many respondents reported feeling isolated and lacking support and experienced significant psychological distress, such as symptoms of post-traumatic stress disorder. Suggestions for improvement included better communication, transparency, impartiality, adherence to timelines, proactive support and oversight, and opportunities for learning and reparation post-investigation.

Clinical implications
Mental health service providers should recognise the multifaceted nature of complaints and provide comprehensive support and guidance to psychiatrists undergoing investigations.
Task-dependent functional connectivity changes in response to varying levels of social support
Authors: Burhanoglu Birce Begum , Uslu Ozgul , Ozkul Burcu , Oguz Kaya , Eroglu-Koc Seda , Kizilates-Evin Gozde , Candemir Cemre , Erdogan Yigit , Mull Defne Dakota , Kitis Omer , Gonul Ali Saffet 
Published: October 2024

Background
Having social support improves one's health outcomes and self-esteem, and buffers the negative impact of stressors. Previous studies have explored the association between social support and brain activity, but evidence from task-dependent functional connectivity is still limited.

Aims
We aimed to explore how gradually decreasing levels of social support influence task-dependent functional connectivity across several major neural networks.

Method
We designed a social support task and recruited 72 young adults from real-life social groups. Of the four members in each group, one healthy participant (18 participants in total) completed the functional magnetic resonance imaging (fMRI) scan. The fMRI task included three phases with varying levels of social support: high-support phase, fair phase and low-support phase. Functional connectivity changes according to three phases were examined by generalised psychophysiological interaction analysis.

Results
The results of the analysis demonstrated that participants losing expected support showed increased connectivity among salience network, default mood network and frontoparietal network nodes during the fair phase compared with the high-support phase. During the low-support phase, participants showed increased connectivity among only salience network nodes compared with the high-support phase.

Conclusions
The results indicate that the loss of support was perceived as a threat signal and induced widespread increased functional connectivity within brain networks. The observation of significant functional connectivity changes between fair and high-support phases suggests that even a small loss of social support from close ones leads to major changes in brain function.
Clinicopathologic Characteristics Influencing Overall Survival of Patients With Early- Versus Average-Onset Colorectal Cancer at a Tertiary Care Center in Indonesia
Authors: Hutajulu Susanna Hilda , Howdon Daniel , Putra Yasjudan Rastrama , Susanti Susanti , Heriyanto Didik Setyo , Yoshuantari Naomi , Handaya Adeodatus Yuda , Utomo Bambang Purwanto , Dwidanarti Sri Retna , Kurnianda Johan , Sudoyo Aru Wisaksono , Ilyas Mohammad , Allsop Matthew John 
Published: October 2024

PURPOSE
There has been a global increase in early-onset colorectal cancer (EOCRC), yet there has been very limited exploration of its impact in Indonesia. This study aimed to determine the clinicopathologic characteristics and the overall survival (OS) of EOCRC compared with those of average-onset colorectal cancer (AOCRC).

METHODS

Medical records were retrospectively reviewed from all patients presenting with colorectal cancer (CRC) at Dr Sardjito General Hospital (Yogyakarta, Indonesia) between 2016 and 2019. Sociodemographic, clinicopathologic, and treatment variables were extracted.
t
Tests were used to compare characteristics of EOCRC and AOCRC patient groups. The Cox proportional hazards regression model was used to analyze age and other potential prognostic factors.

RESULTS

The total population (N = 1,276) comprised EOCRC (n = 149; 11.7%) and AOCRC (n = 1,127; 88.3%) patients. EOCRC patients were more likely to have a higher education level, be single, have out-of-pocket insurance, be underweight, and have signet ring histology (all
P
values <.05), compared with AOCRC patients. EOCRC and AOCRC groups had a comparable estimated 5-year OS of 34.2% and 36.9%, respectively. In multivariable analyses, performance status (Eastern Cooperative Oncology Group), hemoglobin level, cancer stage, and treatment intention were independent prognostic factors for OS (all
P
values <.05).

CONCLUSION
To our knowledge, this first major study of EOCRC in Indonesia highlights its role in the overall burden of CRC and its connection with social determinants of health. Patients with EOCRC are more commonly underweight and generally have a higher proportion of signet ring histology than AOCRC, yet OS in both groups is similar. Future research is required to identify risk factors to inform the content and focus of public health education activities, alongside delineating the biology and causes of early and average onset of the disease.
Σχεδίαση και ανάπτυξη εφαρμογής επαυξημένης πραγματικότητας για φορητές συσκευές για τον εμπλουτισμό του λεξιλογίου σε παιδιά στο φάσμα του αυτισμού
Authors: Κουκουνάρα Μαρία , Χατζηνικολάου Κορνηλία 
Published: October 2024

Το παρόν άρθρο μελετά την αξιοποίηση της τεχνολογίας της Επαυξημένης Πραγματικότητας (ΕΠ) στα πλαίσια ενίσχυσης των δεξιοτήτων των παιδιών προσχολικής αγωγής με Διαταραχές Αυτιστικού Φάσματος. Ειδικότερα, το άρθρο στοχεύει στην σχεδίαση και ανάπτυξη εφαρμογής ΕΠ για τον εμπλουτισμό του λεξιλογίου των παιδιών με ΔΑΦ, η οποία δύναται να χρησιμοποιηθεί στην εκπαιδευτική διαδικασία. Η εφαρμογή ΕΠ «Καρτόλεξο» καλύπτει το βιβλιογραφικό κενό που εντοπίζεται στις εφαρμογές Επαυξημένης Πραγματικότητας που απευθύνονται σε άτομα με ΔΑΦ για την ανάπτυξη των κοινωνικών τους δεξιοτήτων. Στην έρευνα συμμετείχαν 8 παιδιά προσχολικής αγωγής που βρίσκονται στο φάσμα του αυτισμού και η εφαρμογή αξιολογήθηκε από 3 εκπαιδευτικούς Πρωτοβάθμιας Εκπαίδευσης με εξειδίκευση στην Ειδική Αγωγή. Για να διερευνηθεί η αποτελεσματικότητα και η ευχρηστία της εφαρμογής ΕΠ «Καρτόλεξο» αξιοποιήθηκε η μεικτή μεθοδολογία με την συλλογή, ανάλυση και ερμηνεία ποιοτικών και ποσοτικών δεδομένων. Πιο συγκεκριμένα, οι εκπαιδευτικοί κλήθηκαν να απαντήσουν στην ημιδομημένη συνέντευξη και στο γραπτό ερωτηματολόγιο ευχρηστίας. Η εφαρμογή ΕΠ «Καρτόλεξο» σχεδιάστηκε παιδαγωγικά σύμφωνα με τις αρχές του εποικοδομισμού και η λειτουργικότητα της εφαρμογής βασίστηκε στους κανόνες ευχρηστίας του Nielsen (1993). Από την ανάλυση των δεδομένων προέκυψε ότι η εφαρμογή «Καρτόλεξο» μπορεί να βοηθήσει τα παιδιά με ΔΑΦ να αναπτύξουν το λεξιλόγιό τους με διασκεδαστικό τρόπο. Συμπερασματικά, η εφαρμογή ΕΠ «Καρτόλεξο» χαρακτηρίστηκε κατάλληλη, λειτουργική, εύχρηστη και με πλούσιο περιεχόμενο.
Τα είδη της γονεϊκής επιτήρησης κατά τη χρήση του διαδικτύου από παιδιά προσχολικής ηλικίας: μία εμπειρική μελέτη
Authors: Κασιμίδου Αναστασία 
Published: October 2024

Η χρήση των νέων τεχνολογιών έχει κατακλύσει τη σημερινή ελληνική και παγκόσμια πραγματικότητα και έχει επεκταθεί και σε πολύ νεότερες ηλικίες, όπως η προσχολική ηλικία. Η παρούσα έρευνα σκοπεύει να διερευνήσει τα κίνητρα των γονέων για τη χρήση ηλεκτρονικών συσκευών συνδεδεμένων στο διαδίκτυο από παιδιά προσχολικής ηλικίας και το είδος γονεϊκής επιτήρησης (γονεϊκή στήριξη και γονεϊκός έλεγχος) που ασκείται στη χρήση τους. Χρησιμοποιήθηκε σταθμισμένο ερωτηματολόγιο σε 149 γονείς παιδιών, ηλικιών από 3 έως 6 ετών. Τα αποτελέσματα έδειξαν ότι τα κύρια κίνητρα των γονέων για τη χρήση των συσκευών από τα παιδιά είναι η ψυχαγωγία, η εκπαίδευση και η εξοικείωση με τις νέες τεχνολογίες. Οι γονείς επιδεικνύουν εξίσου γονεϊκή στήριξη και γονεϊκό έλεγχο στην επιτήρηση των συσκευών αυτών. Η ομάδα των ισορροπημένων γονέων υπερτερεί αυτής των προστατευτικών, υποστηρικτικών και αποστασιοποιημένων γονέων και δεν εμφανίζεται καθόλου η ομάδα των αυταρχικών γονέων σε αντίθεση με άλλες έρευνες σε χώρες της Ευρώπης. Όσον αφορά τα παιδιά, φάνηκε ότι τα αγόρια και τα παιδιά 4 με 4,5 ετών ελέγχονται και στηρίζονται περισσότερο. Επίσης, όσο αυξάνεται ο αριθμός παιδιών στην οικογένεια μειώνεται ο βαθμός επιτήρησης.
The Game of Thrones Quest for Optimality: A Role Playing Game for Teaching the Art of Linear Programming
Authors: Beliën Jeroen , De Boeck Liesje , Goossens Dries , Quttineh Nils-Hassan , Vermeir Jens 
Published: October 2024

To stimulate practicing modeling skills, we develop an attractive educational team game embedded in an Excel spreadsheet. The game covers aspects of blending problems, production process problems, transportation problems, work scheduling problems, multiperiod production planning problems, and sensitivity analysis, all within a context that relates to a popular fictional theme, that is, Game of Thrones. The game can be used in an introductory linear programming (LP) course as an additional practice or repetition exercise. It can also be used to refresh students’ knowledge of LP modeling at the start of a subsequent integer programming or operations research course. Since 2016, the game has been used successfully in a first course on LP for undergraduate students following the Bachelor of Business Engineering program at KU Leuven (Belgium). Besides our positive experience, two formal student surveys revealed that most students (strongly) agreed that the game increased their interest in operations research. Furthermore, although only a few students watched Game of Thrones, most students liked the fictional theme. Supplemental Material: The “Game of Thrones: The Quest for Optimality” assignment file is available at https://doi.org/10.1287/ited.2024.0080 . The Teaching Note and data and files are available at https://www.informs.org/Publications/Subscribe/Access-Restricted-Materials .
Role of procedure-specific consent forms in clinical practice: a systematic review
Authors: Norvill J , Bent C , Mawhinney JA , Johnson N 
Published: October 2024

Introduction Consent forms play an active role in the consent process with generic, handwritten consent forms (GCF) often the standard across the National Health Service. Increasingly, procedure-specific consent forms (PSCF) are being used as an alternative. However, concerns remain about whether they meet the standard for consent. We therefore conducted a systematic review with the objectives of investigating evidence for PSCF, study methodology and medicolegal criteria. Methods This systematic review was prospectively registered on PROSPERO (CRD42023392693) and conducted from 1 January 1990 to 17 March 2023 using the MEDLINE, Embase, CINAHL, CENTRAL and Emcare databases. A grey literature search was also performed. All studies evaluating PSCF in medical and surgical settings were included. Risk-of-bias analysis was performed using ‘RoB 2’ and ‘ROBINS-I’. Meta-analysis was not possible because of the results’ heterogeneity. Findings We identified 21 studies investigating PSCF with no systematic reviews and meta-analyses reported. Most studies were quality improvement projects (n = 10) followed by randomised studies (n = 5). No definitive legal guidance for PSCFs and no studies assessing their role in litigation post-procedural complications were identified. PSCFs were associated with improved documentation (70%–100%; n = 11) and legibility (100%; n = 2) compared with GCF. Randomised studies (n = 4) investigating patient understanding and recall for PSCF were inconclusive compared with GCF. Conclusions The heterogeneous evidence available merely demonstrates superior documentation of PSCF compared with GCF. Studies do not adequately investigate the impact on informed consent and fail to address the associated legal concerns. Further randomised studies with patient-centric outcomes and consideration for medicolegal criteria are needed.
Impacts of resident physician unionization on house staff compensation
Authors: Tyagi Sidharth , Shah Rema J. , Huttler Joshua , Kayani Jehanzeb , Ghovanloo Mohammad-Reza , Effraim Philip R. 
Published: October 2024

Background
Physicians-in-training in the United States work long hours for relatively low wages. In response to increased economic burden, the popularity of unionization in residency training programs has increased dramatically. In this study, we conducted a cross-sectional investigation of the association between unionization status and Internal Medicine PGY-1 compensation and benefits.

Methods and findings
We compiled residency salary and benefits data from all Internal Medicine residency training programs in the United States. Using a mixed effects modeling approach, we evaluated the differences in salary and total compensation while adjusting for regional factors and cost-of-living differences. In aggregate, PGY-1 salary was higher for unionized vs. non-unionized programs ($69648 vs. $62214; [95% CI 670.7–3563.7]). However, there was no difference after adjusting for cost-of-living ($62515 vs $62475; [95% CI. -1317.5, 1299.7]). Unionized programs do however offer greater monetary benefits in the form of stipend disbursements, and total compensation is higher in unionized vs. non-unionized residency programs ($65887 vs $63515; [95% CI 607.6, 3551.5]).

Conclusions
Unionized residency programs offer higher total compensation packages than their non-unionized counterparts. This increase in compensation is driven in large part by an increased variety and amount of stipend disbursement.