bluuebunny/crossref_metadata_2025_split huggingface dataset:
Japanese care workers’ perception of dementia‐related physically and psychologically aggressive behaviour symptoms
Authors: Hirata Hiromi , Harvath Theresa A. 
Published: May 2016

AimThe purpose of this study was to explore Japanese care workers’ attributions, beliefs and cultural explanations of physically and psychologically aggressive behaviour symptoms.BackgroundPhysically and psychologically aggressive behaviour symptoms by older people with dementia have been associated with occupational stress among care workers in the United States and other Western countries and may contribute to staff turnover. However, few studies related to this issue have been conducted in Japan, where care worker reaction to physically and psychologically aggressive behaviour symptoms might be different because of cultural and customary differences in how care is provided for older people.MethodThis study reports on the results of three open‐ended questions that were part of a larger study that explored Japanese care workers’ experiences with aggressive behaviour symptoms in persons with dementia. Convenience sampling was used to recruit 137 care workers in 10 nursing homes in the northern and western areas of Japan. The answers to the open‐ended questions were analysed using a content analysis.FindingsMost of the participants indicated that they believed that physically and psychologically aggressive behaviour symptoms came from residents’ stress from dementia. Approximately, one‐fourth of the participants responded that Japanese values such as chu (loyalty) and joge (hierarchy) influenced their work with residents with physically and psychologically aggressive behaviour symptoms. Seventeen participants (12%) commented either that they respected older people or that they respected older people as persons who had had many experiences in life. Interestingly, 43 responses (41.0%) indicated that physically and psychologically aggressive behaviour symptoms influenced quality of care positively, while, not surprisingly, about 30 responses indicated that those behaviour symptoms influenced quality of care negatively.Implications for practiceFindings from this study indicate that the training and education needs to focus on understand and preventing the effects of stress for individuals living with dementia to reduce aggressive incidents and increase recruitment and retention of care workers.
Cryoablation with an 8‐mm‐Tip Catheter for Right‐Sided Accessory Pathways in Children
Authors: TANIDIR IBRAHIM CANSARAN , ERGUL YAKUP , OZTURK ERKUT , DALGIC FUHEDA , KIPLAPINAR NESLIHAN , TOLA HASAN TAHSIN , AKDENIZ CELAL , TUZCU VOLKAN 
Published: May 2016

BackgroundCryoablation is increasingly utilized in children because of its safety profile. Recently, larger catheter tips have been more widely used to improve long‐term success rates. The aim of this study was to assess the safety and efficacy of 8‐mm‐tip catheters for cryoablation of right‐sided accessory pathways (APs) in children.MethodsElectrophysiological procedures were performed using the EnSite™ system (St. Jude Medical Inc., St. Paul, MN, USA).ResultsBetween July 2010 and July 2014, 54 patients (mean age: 13.1 ± 3.7 years) underwent cryoablation using an 8‐mm‐tip catheter. In 18 of 54 (33%) patients where an 8‐mm‐tip catheter was the first‐choice catheter, the success rate was 18 of 18 (100%). There was a history of previous failed attempts or recurrence with radiofrequency ablation and/or 6‐mm‐tip cryoablation in 36 of 54 (67%) patients. The success rate in these patients was 24 of 36 (67%). No fluoroscopy was used in 34 of 54 procedures. The recurrence rate was six of 42 (14%) during a mean follow‐up period of 32 ± 15 months. In one patient, transient atrioventricular block occurred.ConclusionsCryoablation with an 8‐mm‐tip catheter for right‐sided APs in children who weigh over 40 kg appears to be safe and acutely effective in cases where conventional ablation methods fail and also as a first choice for ablation procedure. However, the recurrence rate still seems to be high.
Reduction of Surgical Complications in Dogs and Cats by the Use of a Surgical Safety Checklist
Authors: Bergström Annika , Dimopoulou Maria , Eldh Mikaela 
Published: May 2016

ObjectiveTo examine whether the use of a surgical safety checklist (SSC) could reduce the incidence of complications after small animal surgery.Study DesignProspective clinical study.Animals: Client‐owned dogs and cats (n = 520).MethodsConsecutive cases were enrolled in the study, the first 300 cases without implementation of the surgical checklist (SSC−), followed by 220 cases with implementation of the checklist (SSC+). The checklist was adapted from the WHO surgical checklist and consisted of three different check points: (1) before induction of anaesthesia (sign in), (2) before surgical incision (time out), and (3) before recovery (sign out). In‐hospital outcomes were prospectively recorded, and complications within 6 weeks were retrospectively recorded by reviewing medical records and by telephone interviews with owners. The severity of each recorded complication was graded as minor, moderate, or severe. Comparisons were made between SSC− and SSC+ outcomes.ResultsThere were significantly more complications in SSC− animals than SSC+ animals (SSC− 52/300 vs. SSC+ 15/220, P = .0003). There was a significantly higher frequency of SSI (P = .045) and wound healing complications (P = .0006) for SSC− animals than SSC+ animals.ConclusionThe frequency and severity of postoperative complications was significantly decreased after introduction of a surgical checklist. All veterinary hospitals should consider using a surgical checklist. Compliance with implementation of the checklist is important for success.
Advancing social work professionalism: Standards for management and leadership in Aotearoa New Zealand
Authors: Webster Mike , McNabb David , Darroch John 
Published: May 2016

In 2004, management was recognised by the International Federation of Social Workers (IFSW) as one of 13 ‘core purposes’ of the global profession. Taking that recognition as a starting point, this article advances the notion that the pre-eminent function of management in social work organisations is to serve, advocate for and integrate the remaining 12 pur- poses. We further propose that these 12 purposes express the profession’s commitment to human rights and social justice as social work’s distinctive values – that social justice has an organisational dimension. Proceeding from that philosophical base, this paper introduces a research project to develop standards for social work management and leadership uniquely designed for Aotearoa New Zealand. The authors suggest that the IFSW core purpose statement informs and underpins the project. Standards developed by the profession in the United States and England are reviewed and elements drawn from those sources assessed for potential application to New Zealand. The concepts of leadership and management are examined to determine whether they are interchangeable terms, while noting that in the two overseas jurisdictions leadership is privileged. The article concludes by way of an introduction to the preliminary findings of the research project for future treatment.
Volunteer peer supervision: In an ever-changing social service environment
Authors: Rushton Jason 
Published: May 2016

The purpose of this article is to start a discussion around the importance of peer super- vision with social service volunteers (New Zealand Federation of Voluntary Welfare Organisations [NZFVWO], 2001, pp. 61-63). This will be achieved by addressing the history of volunteerism and the rise of Charitable Trusts (Styles, 1979, pp. 86-88). The structure of volunteerism changed, as policymakers identified the importance of including specific volunteer’s roles and functions in legislation. Furthermore, policymakers began introducing clarification around peer supervision and peer support, linking the importance of supervision for volunteerism in the social services (NZFVWO, 2001, pp. 61). The introduction of peer supervision for volunteers in the social services is to provide accountability around professional practice and registration for many social service professions. The importance of peer supervision for volunteers working in the social services should be viewed as a safeguard to provide better practice for the volunteer, client and agency (O’Donoghue, 1999, p. 7). Volunteering New Zealand (VNZ) offer an alliance with supporting agencies and government around volunteering best practice in the support and development of managers and coordinators of volunteers (VNZ, 2014, para 1-15). An example of this is the Volunteer Army, which came to fruition around the Christchurch earthquakes, getting the community working alongside each other to support and help those in need. However, none of these professional bodies offer a code of ethics to provide guidelines to volunteers. The Aotearoa New Zealand Association of Social Workers (ANZASW) does offer a Code of Ethics, not only to social workers but to all social services and volunteers (Beddoe & Randal, 1994, p. 31), which could be incorporated and used as a guideline. Although social work has a code of ethics guideline there is still some debate around mandatory registration to provide accountability and safeguard clients and social work practice.
Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome
Authors: Cullen Louise , Greenslade Jaimi H , Menzies Louven , Leong Ashley , Than Martin , Pemberton Christopher , Aldous Sally , Pickering John , Dalton Emily , Crosling Bianca , Foreman Rachelle , Parsonage William A 
Published: May 2016

ObjectiveTo define the association between time taken to present to the emergency department (ED) with symptoms of possible acute coronary syndrome (ACS) and 1-year outcomes. We also determined whether particular patient characteristics are associated with delays in seeking care after symptom onset.MethodsWe collected data, which included a customised case report form to record symptom onset, on adult patients presenting with suspected ACS to two EDs in Australia and New Zealand. Such patients were followed up prospectively for 1 year. The composite primary endpoint included death, acute myocardial infarction, unstable angina pectoris treated with revascularisation or readmission with heart failure occurring after discharge but within 12 months after the index presentation.ResultsACS was diagnosed at presentation in 420 (16.8%) of 2515 patients recruited. Cox regression was conducted to assess the relationship between presentation time and the rate of primary endpoints after controlling for age, ethnicity, prior angina, prior coronary artery bypass graft and index diagnosis. Middle (2–6 h) and late presenters (>6 h postsymptom onset) developed the primary endpoint at a rate 1.22 (95% CI 0.80 to 1.85) and 1.57 (1.07 to 2.31) times higher than early presenters. Patients with known risk factors and cardiovascular disease were more likely to present late to the ED.ConclusionsThere is an independent association between time to presentation and 1-year cardiac outcomes following initial chest pain assessment for ED patients with possible cardiac chest pain in the Australian and New Zealand setting. This association occurred irrespective of the eventual diagnosis. Effective public health campaigns and other measures that facilitate early presentation with symptoms for patients with symptoms suggestive of ACS are justified and may improve prognosis.Trial registration numberACTRN12611001069943.
The application of susceptibility-weighted MRI in pre-interventional evaluation of intracranial dural arteriovenous fistulas
Authors: Jain Narendra Kumar , Kannath Santhosh Kumar , Kapilamoorthy Tirur Raman , Thomas Bejoy 
Published: May 2016

Background and purposeDetection and characterization of intracranial dural arteriovenous fistula (DAVF) is important to plan appropriate therapeutic management. The aim of this study was to analyze the utility of susceptibility-weighted MRI (SWI) in the pre-therapeutic assessment of DAVF in comparison with gold standard digital subtraction angiography (DSA).Materials and methodsProspectively, 26 patients with DAVFs underwent a thorough clinical examination and MRI including SWI followed by cerebral DSA. Two observers blinded to the DSA findings evaluated conventional MRI and SWI images and identified the fistulous area (FA), cortical venous reflux (CVR), and cortical venous ectasia (CVE) and compared these observations with the DSA findings documented by a third observer.ResultsAggressive clinical symptoms were observed in 31% of patients and benign features were noted in 69% of DAVFs. Conventional MRI could identify the FA in only 27% of patients. SWI accurately located 75% of all the FAs in 23 patients. However, SWI failed to identify DAVFs in three patients. CVR was detected in 89.6% of all aggressive DAVFs. The accuracy of SWI to identify CVE was 100% and the extent and degree correlated with DSA observations.ConclusionsSWI is a reliable non-invasive tool for the localization and characterization of DAVFs and is superior to conventional MRI in the evaluation of DAVFs. This sequence can demonstrate underlying cerebral hemodynamic stresses with a high degree of accuracy and provide valuable pre-therapeutic information.
Endovascular thrombectomy in the setting of aortic dissection
Authors: Reznik Michael E , Espinosa-Morales Aixa Damaris , Jumaa Mouhammad A , Zaidi Syed , Ducruet Andrew F , Jadhav Ashutosh P 
Published: May 2016

BackgroundRecent studies have validated the use of endovascular thrombectomy in large vessel ischemic stroke provided patients are selected appropriately. However, to our knowledge, there have been no previously reported cases of endovascular thrombectomy in patients with aortic dissection. We report three such cases, two with chronic aortic dissections (including one with a history of Marfan syndrome) and another with an acute type B dissection.MethodsCase studies and review of relevant literature.ResultsThree patients with a history of aortic dissection presented with acute onset right middle cerebral artery syndromes, two of whom had chronic aortic dissections that were status-post graft repair, while a third had an acute type B aortic dissection that had been managed with a femoral-to-femoral bypass. None of the three were candidates for intravenous tissue plasminogen activator. All three were found to have proximal right M1 occlusions on non-invasive imaging and were taken for endovascular thrombectomy via transfemoral, transradial, and transbrachial approaches, respectively. All three had successful recanalization (with Thrombolysis In Cerebral Infarction (TICI) 2b, TICI 3, and TICI 2b flow, respectively) along with clinical improvement, and none had procedure-related complications.ConclusionsThese three cases suggest that endovascular thrombectomy is feasible and can be done safely and efficaciously in patients with aortic dissections and those with Marfan syndrome, although the risks and benefits should be considered as part of any decision-making process. Given that endovascular therapy for acute stroke is now in many situations part of standard care, further studies will be necessary to delineate more precise inclusion and exclusion criteria.
Abstract A110: CBP501 suppresses cell migration, invasion and epithelial-mesenchymal transition (EMT) in non-small cell lung carcinoma
Authors: Saito Naoya , Mine Naoki , Kufe Donald W. , Von Hoff Daniel D. , Kawabe Takumi 
Published: May 2016

Abstract
The CBP501 calmodulin-binding peptide is an anti-cancer drug candidate that has completed two Phase II clinical trials for patients with malignant pleural mesothelioma and non-small cell lung carcinoma (NSCLC). CBP501 was previously identified as a unique G2 checkpoint-directed agent and as an enhancer of cisplatin (CDDP) uptake. In post-trial analysis of NSCLC patients, it was found that overall survival (OS) was prolonged in a subpopulation with normal white blood cell counts (WBC) (WBC &lt; 8000).
Here, we show that CBP501 inhibits cell migration (by 42% (A549) and 70% (H1299) with 1μM) and invasion (by 32% (A549) and 49% (H1299) with 1μM) of NSCLC cells in a dose-dependent manner using a transwell assay and a wound healing assay. In addition, inhibition of EMT by CBP501 was assessed by observing 3D spheroid morphology on NanoCulture Plate (NCP). The collapse of the spheroids typically observed upon TGFβ treatment was decreased by CBP501. These results show that CBP501 reduces TGFβ-induced EMT. Furthermore, CBP501 decreases expression of vimentin, a canonical marker of EMT and reduces the up-regulation of vimentin expression by TGFβ. Vimentin protein has important effects on the function of lamellipodia and invadopodia during cell migration and invasion and is related to cancer progression via EMT.
These results suggest that CBP501 may inhibit tumor metastasis through suppression of EMT, which may have contributed to the observed OS prolongation in humans.
Citation Format: Naoya Saito, Naoki Mine, Donald W. Kufe, Daniel D. Von Hoff, Takumi Kawabe. CBP501 suppresses cell migration, invasion and epithelial-mesenchymal transition (EMT) in non-small cell lung carcinoma. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A110.
Abstract A112: Observed separation of survival curves by WBC in CBP501-treated patients leads to experimental identification of macrophage functions suppressed by CBP501
Authors: MINE NAOKI , Yamamoto Sayaka , Saito Naoya , Sato Takuji , Sakakibara Keiichi , Kufe Donald W. , Von Hoff Daniel D. , Kawabe Takumi 
Published: May 2016

Abstract
The CBP501 calmodulin-binding peptide is an anti-cancer drug candidate that has completed a Phase II clinical trial for patients with non-small cell lung carcinoma (NSCLC). CBP501 was also previously identified as a unique G2 checkpoint-directed agent and as an enhancer of cisplatin (CDDP) uptake.
In a post-trial analysis of the NSCLC patients, it was found that the survival was statistically significantly different between subpopulations with normal white blood cell counts (WBC) (WBC &lt; 8000) and high WBC (WBC &gt; 8000). Notably, treatment by CDDP with or without CBP501 had no effect on the neutrophil oxidative burst or phagocytosis
Here, we show that CBP501 inhibits several functions of macrophages. The LPS-stimulated production of several cytokines (IL-6. TNF-alpha and IL-10) by macrophages were suppressed by CBP501 treatment in vitro. The population of potential cancer stem-like cells was reduced by CBP501 in co-cultures of macrophages and tumor cell lines. In human macrophages isolated from peripheral blood-derived monocytes or THP-1 monocytic cells, phagocytic activity induced by IgG-conjugated beads was suppressed by in vitro CBP501 treatment. The neutrophil extracellular traps (NETs), which are supposed to be cleared by macrophages, were increased by CBP501 in response to leukocyte stimulation. Thrombotic tendency was increased in LPS- and CBP501-treated mice. These results suggest that the inhibition of macrophages by CBP501 could explain the observed dramatic separation of survival curves by WBC in patients with NSCLC.
Many reports (Roy Noy and Jeffrey W. Pollard Immunity. 2014) indicate that tumor associated macrophages (TAMs) promote metastasis. To see if CBP501 might affect this relationship between macrophage activity and metastasis, we performed in vivo mouse study of mice bearing subcutaneous Lewis lung carcinomas. Results showed reduced metastasis to the lung upon CBP501 administration. Further investigation is underway to clarify the role of CBP501 in modulating the earlier characterized TAM-promoted metastasis.
Citation Format: NAOKI MINE, Sayaka Yamamoto, Naoya Saito, Takuji Sato, Keiichi Sakakibara, Donald W. Kufe, Daniel D. Von Hoff, Takumi Kawabe. Observed separation of survival curves by WBC in CBP501-treated patients leads to experimental identification of macrophage functions suppressed by CBP501. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A112.
Abstract A125: Antibody targeted steroids for the treatment of cancer
Authors: Prudent James R. , Marshall David , Murphy John , Hall Chad , Harried Scott 
Published: May 2016

Abstract
Purpose:
The cardiac glycoside family of steroidal drugs has been shown to possess novel and potent antitumor activities in rodents. Yet most likely due to their cardiotoxic nature, these drugs have failed to show clinical efficacy at doses deemed safe to humans. In order to determine if this drug class could be made safer and more efficacious, we assessed the antitumor activity of a new antibody drug conjugate system in which these steroidal compounds are tethered to antibodies that direct them to protein complexes found on various types of cancer cells.
Experimental design:
The activity and safety profiles of these novel antibody drug conjugates were examined using multiple cancer cell lines, normal cells, xenograft models in immunodeficient mice and non-human primates.
Results:
We identified multiple monoclonal antibodies that when conjugated to cardiac glycosides through long stable linkers, could provide cell killing activity independent of effector functions. When tested in vitro on a number of cancer cell lines, these active antibody drug conjugates termed Extracellular Drug Conjugates or EDCs, displayed potent cytotoxic activities with half maximal effective concentration (EC50) in sub-nanomolar ranges via a pathway resembling apoptosis and/or necroptosis. These activities were dependent on the expression of the corresponding antibody, linker length and steroid chemistry. In vivo using various tumor xenograft models, the EDCs were able to partially or completely regress tumor growth when 1 to 10 mgs/kg were administered intravenously. The EDCs were also found to assist various clinically approved therapies regress tumor growth. Finally, because cynomolgus monkeys respond to cardiac glycosides is similar to humans, 5mgs/kg of EDC was slowly infused intravenously into a cynomolgus monkey with no adverse effects observed even though the relative blood concentration of the cardiac glycoside attached reached 1500 nanomolar.
Conclusion:
These results support efforts to further evaluate these unique targeting antibody drug conjugates for the treatment of human cancers.
Citation Format: James R. Prudent, David Marshall, John Murphy, Chad Hall, Scott Harried. Antibody targeted steroids for the treatment of cancer. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A125.
Abstract A138: Targeting activated CRAF fusions in pediatric low-grade gliomas
Authors: Jain Payal , Fierst Tamara , Silva Amanda , Budlow Jake , Boucher Katie , Han Harry , Storm Phillip B. , Waanders Angela , Resnick Adam C. 
Published: May 2016

Abstract
This abstract has been withheld from publication due to its inclusion in the AACR-NCI-EORTC Molecular Targets Conference 2015 Official Press Program. It will be posted online at the time of its presentation in a press conference or in a session: 10:00 AM ET Friday, November 6.
Citation Format: Payal Jain, Tamara Fierst, Amanda Silva, Jake Budlow, Katie Boucher, Harry Han, Phillip B. Storm, Angela Waanders, Adam C. Resnick. Targeting activated CRAF fusions in pediatric low-grade gliomas. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A138.