bluuebunny/crossref_metadata_2025_split huggingface dataset:
МЕДСЕСТРИНСТВО В УКРАЇНІ XXI СТОЛІТТЯ – ПОГЛЯД НА ПРОБЛЕМУ
Authors: Hudyma A. A. 
Published: October 2017

Мета роботи – розглянути роль середньої ланки медичних працівників в умовах розвитку вітчизняної охорони здоров’я і намітити основні напрямки вдосконалення їх підготовки і застосування у сфері надання медичних послуг.Основна частина. У статті висвітлено сучасне бачення розвитку медсестринства в Україні з позицій вимог, які диктує суспільство, щодо якості надання медичних послуг. Показано доцільність широкого впровадження симуляційного навчання в медицині як складової підготовки високоякісного медичного персоналу середньої ланки. Сучасна система освіти володіє низкою традиційно сформованих дидактичних методів і прийомів, однак у сучасних умовах цього недостатньо. Широке впровадження високотехнологічної медицини, у якій виникають нові принципи і правила діагностично-лікувального процесу, вимагає від фахівця значно ширшого спектра знань і вмінь, що стирає грані між традиційним розподілом праці в системі “медична сестра – фельдшер – лікар”.Висновок. У цих умовах слід пам’ятати, що робота в центрі симуляційного навчання вимагає від викладача додаткових знань і вмінь, постійної активної місії на занятті. Тому в ряді країн співвідношення педагогічного навантаження викладача у центрі симуляційного навчання до рутинного викладання становить 1:3.
High‐Quality Feedback Regarding Professionalism and Communication Skills in Otolaryngology Resident Education
Authors: Faucett Erynne A. , McCrary Hilary C. , Barry Jonnae Y. , Saleh Ahlam A. , Erman Audrey B. , Ishman Stacey L. 
Published: October 2017

ObjectiveThe Accreditation Council for Graduate Medical Education (ACGME) requires competency‐based education for residents and recommends 5 basic features of high‐quality feedback. Our aim was to examine the incorporation of feedback in articles regarding professionalism and interpersonal/communication skills for otolaryngology residency training curriculum.Data SourcesPubMed, Embase, ERIC, Cochrane Library, Web of Science, Scopus, and ClinicalTrials.gov.MethodsWe used studies identified during a systematic review of all indexed years through October 4, 2016.ResultsEighteen studies were included in this review. Professionalism was discussed in 16, of which 15 (94%) examined aspects of feedback. Interpersonal/communication skills were the focus of 16 articles, of which 14 16 (88%) discussed aspects of feedback. Our assessment demonstrated that timeliness was addressed in 8 (44%) articles, specificity in 4 (22%), learner reaction and reflection in 4 (22%), action plans in 3 (20%), and balancing reinforcing/corrective feedback in 2 (13%). Two articles did not address feedback, and 6 did not address aspects of high‐quality feedback. The ACGME‐recommended feedback systems of ADAPT (ask, discuss, ask, plan together) and R2C2 (relationship, reactions, content, and coach) were not reported in any of the studies.ConclusionFeedback is an essential component of graduate medical education and is required by the ACGME milestones assessment system. However, the core feedback components recommended by the ACGME are rarely included in the otolaryngology resident education literature.
Systematic Review of Drug‐Induced Sleep Endoscopy Scoring Systems
Authors: Amos Janine M. , Durr Megan L. , Nardone Heather C. , Baldassari Cristina M. , Duggins Angela , Ishman Stacey L. 
Published: October 2017

ObjectiveTo systematically review the scoring systems used to report findings during drug‐induced sleep endoscopy (DISE) for adults and children with obstructive sleep apnea.Data SourcesPubMed, CINAHL, EBM Reviews, Embase, and Scopus databases.Review MethodsThis is a systematic review of all indexed years of publications referring to scoring of DISE for children and adults with obstructive sleep apnea. The type of DISE scoring system utilized was the primary outcome. PRISMA guidelines were followed to carry out this review; articles were independently reviewed by 2 investigators. All pediatric and adult studies that utilized ≥1 DISE grading systems were included.ResultsOf 492 identified abstracts, 44 articles (combined population, N = 5784) were ultimately included; 6 reported on children, 35 on adults, and 1 on children and adults. Twenty‐one reporting methods were used in these studies, with the most common being the VOTE system (velum, oropharynx, tongue base, and epiglottis; 38.6%) and the Pringle and Croft classification (15.9%). The sites of obstruction most commonly included in a scoring system were the tongue base (62%), lateral pharynx/oropharynx (57%), palate (57%), epiglottis/supraglottis (38%), and hypopharynx (38%). Less commonly included sites were the larynx (29%), velum (23%), nose (23%), tongue (14%), adenoids (10%), and nasopharynx (10%).ConclusionThere is no consensus regarding which scoring system should be utilized to report findings during DISE. The VOTE system and the Pringle and Croft classification were the most frequent scoring systems reported for patients undergoing DISE. Standardization of the reporting of DISE findings would improve comparability among studies.
USPIO-positive MS lesions are associated with greater tissue damage than gadolinium-positive-only lesions during 3-year follow-up
Authors: Kerbrat Anne , Combès Benoit , Commowick Olivier , Maarouf Adil , Bannier Elise , Ferré Jean Christophe , Tourbah Ayman , Ranjeva Jean-Philippe , Barillot Christian , Edan Gilles 
Published: October 2017

Background: Identifying in vivo the processes that determine lesion severity in multiple sclerosis (MS) remains a challenge. Objectives: To describe the dynamics of ultrasmall superparamagnetic iron oxide (USPIO) enhancement in MS lesions and the relationship between USPIO enhancement and microstructural changes over 3 years. Methods: Lesion development was assessed at baseline, Months 3, 6, and 9, using magnetic resonance imaging (MRI) with gadolinium and USPIO. Microstructural changes were assessed at baseline, Months 3, 6, 9, 12, 18, 24, and 36, using relaxometry, magnetization transfer, and diffusion-weighted imaging. Results: We included 15 patients with clinically isolated syndrome. In the 52 MRI scans acquired with USPIO, 22 lesions were USPIO and gadolinium positive, and 44 were USPIO negative but gadolinium positive. Lesions no longer exhibited sustained USPIO enhancement 3 months later. At baseline, lesions that were both USPIO and gadolinium positive had lower magnetization transfer ratio values (common language effect size = 0.84, p = 0.0005) and lower fractional anisotropy values (0.83, p = 0.001) than gadolinium-positive-only lesions. USPIO-positive lesions remained associated with greater damage than gadolinium-positive-only lesions throughout the 3-year follow-up. Conclusion: USPIO enhancement, mainly reflecting monocyte infiltration, is transient and is associated with persistent tissue damage after 3 years.
Mechanisms of integrated care in Flanders: A bottom-up perspective
Authors: Dhondt Steven , Hermans Koen , Molema Hanneke , Boermans Sylvie , van der Klauw Denise , Vrijhoef Hubertus JM 
Published: October 2017

Background For some time now, integrated care has been put forward to create a more demand-driven, patient-centred and cost-effective care system. Various conceptual frameworks have been developed to shed light on the complex concept. However, they lack insight into the mechanisms driving integrated care in practice. The aim of this paper is to gain insight into how integrated care is realised in practice. Methods Six cooperation projects in Flanders were compared on five integration mechanisms. A content analysis of secondary sources on each of the cases and semi-structured interviews with representatives of these cases was conducted. The data were analysed using comparison tables. Results Six cases representing five cooperation models in the Flemish health and social care were analysed for the presence of integrated care mechanisms. Six of the 22 mechanisms are present in all case examples. Half of the identified mechanisms concern the integration of professionals. Integrated care in these Flemish cases refers mainly to organising a case meeting, appointing a case manager and dividing the tasks between care professionals. Integration of support is less developed. Conclusions The bottom-up approach to study the practical implementation of mechanisms is a fruitful approach, since it brings into light the complex realities and practicalities of the mechanisms of integration and how they are shaped by local actors in local contexts. The approach shows how Flemish and Belgian policy makers are struggling to scaling up these integration models, whilst at the same time responding to local conditions and needs.
E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine
Authors: Gómez-Escudero Jesús , Moreno Vanessa , Martín-Alonso Mara , Hernández-Riquer M. Victoria , Feinberg Tamar , Colmenar Ángel , Calvo Enrique , Camafeita Emilio , Martínez Fernando , Oudhoff Menno J. , Weiss Stephen J. , Arroyo Alicia G. 
Published: October 2017

ABSTRACT
Cadherin-based intercellular adhesions are essential players in epithelial homeostasis, but their dynamic regulation during tissue morphogenesis and remodeling remain largely undefined. Here, we characterize an unexpected role for the membrane-anchored metalloproteinase MT2-MMP in regulating epithelial cell quiescence. Following co-immunoprecipitation and mass spectrometry, the MT2-MMP cytosolic tail was found to interact with the zonula occludens protein-1 (ZO-1) at the apical junctions of polarized epithelial cells. Functionally, MT2-MMP localizes in the apical domain of epithelial cells where it cleaves E-cadherin and promotes epithelial cell accumulation, a phenotype observed in 2D polarized cells as well as 3D cysts. MT2-MMP-mediated cleavage subsequently disrupts apical E-cadherin-mediated cell quiescence resulting in relaxed apical cortical tension favoring cell extrusion and re-sorting of Src kinase activity to junctional complexes, thereby promoting proliferation. Physiologically, MT2-MMP loss of function alters E-cadherin distribution, leading to impaired 3D organoid formation by mouse colonic epithelial cells ex vivo and reduction of cell proliferation within intestinal crypts in vivo. Taken together, these studies identify an MT2-MMP–E-cadherin axis that functions as a novel regulator of epithelial cell homeostasis in vivo.
Το μέλλον της Ευρωπαϊκής Ένωσης: η ανάγκη για μια συνολική προσέγγιση
Authors: Ιωακειμίδης Π. Κ. 
Published: October 2017

Στο άρθρο αυτό επιχειρείται μια συνολική εξέταση και αξιολόγηση της συζήτησης για το «Μέλλον της Ευρώπης» από την οπτική μιας μικρής χώρας, της Ελλάδας, και με προοπτική τη νέα διεύρυνση της Ευρωπαϊκής Ένωσης (Ε.Ε.) με χώρες της Αν. Ευρώπης και της Μεσογείου. Εξετάζονται ειδικότερα οι κεντρικές παράμετροι που ορίζουν τη δυναμική της συζήτησης για το «Μέλλον της Ευρώπης» με αφετηρία τις Δηλώσεις των Ευρωπαϊκών Συμβουλίων της Νίκαιας (Δεκέμβριος 2000) και του Laeken (Δεκέμβριος 2001 ). Στο πλαίσιο αυτό αναλύονται το ουσιαστικό περιεχόμενο της ενοποιητικής διαδικασίας καθώς και οι πολιτικο-θεσμικές διαστάσεις της Ευρωπαϊκής Ένωσης και τα διάφορα πρότυπα συγκρότησης της Ε.Ε. που έχουν παρουσιασθεί. Στο δεύτερο μέρος του άρθρου συζητούνται οι θέσεις της Ελλάδας σχετικά με τα πρότυπα οργάνωσης της Ευρωπαϊκής Ένωσης (διακυβερνητικό πρότυπο, κοινοτικό πρότυπο, ομοσπονδία εθνικών κρατών). Επιχειρείται, επίσης, να ερμηνευθεί η θέση της Ελλάδας υπέρ της μετεξέλιξης της Ευρωπαϊκής Ένωσης σε πολιτική Ένωση με ομοσπονδιακό περιεχόμενο στη βάση του κοινοτικού προτύπου ολοκλήρωσης.
Unraveling the story behind the Linnaean basionym ofBoucheaprismatica: Revised typification of the nameVerbena prismatica
Authors: Moroni Pablo , O’Leary Nataly 
Published: October 2017

AbstractThe typification of the Linnaean nameVerbena prismaticais revised. A previous neotypification is investigated and it is shown that the choice of Moldenke (Herb. Linn. No. 35.3) must be superseded since a sheet comprising original material has been located in the Linnaean collection at S. The protologue is shown to have comprised a mixture of two elements, one corresponding toSalvia occidentalisand to the traditional concept ofV. prismatica(i.e.,Bouchea prismatica). A lectotype is selected that preserves the current application of the name to a species ofBouchea.
Nuclear and plastid phylogenies suggest ancient intersubgeneric hybridization in the fern genus Pyrrosia (Polypodiaceae), with a classification of Pyrrosia based on molecular and non‐molecular evidence
Authors: Zhou Xin-Mao , Zhang Li-Bing 
Published: October 2017

AbstractThe Old World fern genus Pyrrosia is one of the largest genera in Polypodiaceae. It is estimated to contain up to 100 species distributed in tropical and subtropical South and East Asia, from New Zealand to Siberia and from Africa to Polynesia. The monophyly of Pyrrosia has frequently been questioned, previous molecular analyses have produced conflicting results, and earlier infrageneric classifications have been controversial. We tested the monophyly of the genus and resolved the relation‐ships within the genus using nuclear DNA data and combined plastid and nuclear DNA data. Our study shows that the recently established genus Hovenkampia is confirmed to be sister to Platycerium. Nuclear data do not recover the monophyly of the Niphopsis clade identified by plastid data pointing to the possibility of ancient hybridization between the Niphopsis and the Niphobolus clades. The combined plastid and nuclear data resolve Pyrrosia into four major clades confirming earlier findings. Three of the four major clades are further resolved into four, four, and six subclades, respectively, and the relationships among the major clades and subclades are well resolved. Based on molecular and non‐molecular evidence Pyrrosia is classified into four subgenera: P . subg. Pyrrosia, P. subg. Neoniphopsis, P. subg. Niphobolus, and P. subg. Niphopsis, and the latter three are further classified into four, six, and four sections, respectively. A key to the infrageneric taxa is given. A nomenclatural account of each infrageneric taxon is provided.
Disentangling the Aizooideae: New generic concepts and a new subfamily in Aizoaceae
Authors: Klak Cornelia , Hanáček2 Pavel , Bruyns Peter V. 
Published: October 2017

AbstractRecent phylogenetic reconstruction of the Aizooideae (Aizoaceae) revealed that it and several of its genera are polyphyletic. Whereas the previous phylogeny was only based on chloroplast markers, we utilize here both nuclear and chlo‐roplast markers. The four chloroplast markers together produce a well‐resolved and well‐supported phylogenetic hypothesis, while many branches in the tree derived from the nuclear internal transcribed spacer (ITS) are unsupported. The position of Acrosanthes as sister to Mesembryanthemoideae + Ruschioideae and the close relationship of Tetragonia schenckii to Tribulocarpus(Sesuvioideae) is highly supported by both nuclear and chloroplast markers. We revise the classification of the Aizoaceae, redefining subfamilial and generic boundaries to maintain monophyly. A new fifth subfamily, the Acrosanthoideae subfam. nov., is created for Acrosanthes, an isolated sister‐lineage to the Mesembryanthemoideae + Ruschioideae. It is the only subfamily endemic to mesic fynbos and all other subfamilies are mainly associated with the more arid karroid vegetation. Basal, shortly stipitate ovules and a xerochastic, parchment‐like capsule are synapomorphies for the Acrosanthoideae. The Eurasian endemic annual, Aizoanthemum hispanicum, is not related to the southern African species of Aizoanthemum and is placed in a new genus, Aizoanthemopsis gen. nov. The southern African genera Galenia and Plinthus are embedded within Aizoon. These genera were separated by differences in the size of their flowers. Since these features are highly homoplasious, we place all three under an enlarged Aizoon, which can be recognized by capsules with reduced expanding tissue as well as leaves and/or stems that are covered with silvery hairs or hair‐like or rounded papillae. The Aizooideae now consist of the genera Aizoanthemopsis, Aizoanthemum, Aizoon, Gunniopsis and Tetragonia, with a total of 116 species. Our results also have consequences in the Sesuvioideae, where the generic name Anisostigma is resurrected for Tetragonia schenckii. The two species of Tribulocarpus and the monotypic Anisostigma are sister to the other Sesuvioideae and are characterized by tubular flowers. Since we have synapomorphies for the clade consisting of Anisostigma + Tribulocarpus and for the remainder of the Sesuvioideae (i.e., circumscissile capsules and seeds completely enveloped by an aril), we recognize two tribes, Sesuvieae and Anisostigmateae tr. nov., within the Sesuvioideae. For the expanded concept of Aizoon and for Tetragonia, we propose a new subgeneric classification to reflect the major clades retrieved. In Aizoon, four of the six subgenera are new and for Tetragonia, two of the four subgenera are new. We provide keys to the subfamilies of the Aizoaceae, to the genera and subgenera of the Aizooideae and also to the tribes of the Sesuvioideae. Distribution maps are provided for the Aizooideae, Acrosanthoideae and for the little‐known Anisostigma schenckii.
‘Last night I dreamt I went to Collinwood again’: Vampire adaptation and reincarnation romance in Dark Shadows
Authors: Spooner Catherine 
Published: October 2017

Abstract
Tim Burton’s 2012 film adaptation of the television soap opera Dark Shadows (1966–71) was controversial with fans, who saw it as failing to capture what they loved about the original. This article explores the gothic properties of doubling and repetition in the 1966–71 series and the ways in which they both pre-empt the discourses of adaptation and destabilize the notion of an ‘original’ text from which the adaptation departs. It argues that the reincarnation romance plot, in which an immortal being seeks to find the reincarnation of his or her lost love, extends the vampire/adaptation metaphor in significant new ways. The reincarnation romance also offers a useful model for understanding the adaptation of cult texts, as fans enact their own ‘reincarnation romance’ with the object of their passion. As such, it illuminates the responses of critics and fans to Burton’s film and the broader problems of adapting cult texts. If the television vampire has, until very recently, been overlooked in favour of its cinematic variants, then the case of Dark Shadows reveals the value judgements informing this oversight and restores the television vampire to its full significance.
Original sin: Frontier horror, gothic anxiety and colonial monsters in The Vampire Diaries
Authors: Lush Rebecca M. 
Published: October 2017

Abstract
This article focuses on the CW television series The Vampire Diaries (TVD) (2009–17) and explores how the show uses literary tropes from the early American period commonly used to represent Native Americans. The television series reimagines colonial contact in a way that allows for a range of critical interpretations. The show at turns reproduces colonial rationalizations and rhetoric of land claim and discovery that disenfranchise Native peoples but also allows for ambivalent critiques of the colonial project. More particularly, this article asserts that the Mikaelson vampires (also referred to in the series as ‘The Originals’) replace Native Americans through their assumption of a proto-American identity, then displace actual Native American peoples to occupy the position of surrogate Indian, and finally erase what Native Studies scholars term the tribal real by reproducing fakelore that helps legitimize their American roots. The vampire characters in TVD see themselves as both elite and oppressed and position themselves as ‘surrogate Indians’, a characterization that harks back to some of the earliest depictions and records of historical Virginia as a royal colony filled with displaced elite supporters of the English monarchy.
Subchondral bone condition and total knee arthroplasty in patients with knee osteoarthritis
Authors: Murylyov Valeriy U. , Sorokina Galina L. , Kurilina Ella V. , Ivanenko Leonid R. 
Published: October 2017

Background: 6% of adults suffer from knee joint osteoarthritis. In some cases, the method of choice of treatment is knee arthroplasty. The etiology of osteoarthritis remains largely unclear, but the question of involving the subchondral bone in the pathological process is beyond doubt. One of the causes of pain and other adverse effects after knee replacement may be subchondral bone pathology of the femur and tibia.
Aims: To study the changes in the condyles of the tibia in osteoarthritis and to determine the possible impact of these changes on the development of instability of the knee joint endoprosthesis.
Methods: From December 2014 to February 2016, 56 patients were examined. They underwent total arthroplasty of the knee joint. The average age of the patients was 63 years (from 55 to 78 years). Women were 52 (93%), men - 4 (7%). A histological examination of the resected tibial condyles was carried out to reveal bone pathology.
Results: Typical changes for osteoarthritis were found microscopically. In all cases the signs of osteoporosis were present. A clear histological picture of osteomalacia in the non-calcinated bone was found in 15 women.
Conclusions: Having studied the subchondral bone in these patients we can conclude that the knee endoprosthesis is implanted into a weakened bone, which can lead to adverse effects. To improve the long-term results of surgical treatment, medical correction of bone tissue pathology in the perioperative period is suggested.
Trabecular bone score for the diagnostics of osteoporosis in subjects with type 2 diabetes mellitus: a clinical case
Authors: Grebennikova Tatiana A. , Belaya Zhanna E. 
Published: October 2017

Type 2 diabetes mellitus (T2DM) is associated with higher fracture risk but, better bone mineral density (BMD). Alteration of the skeletal material or microstructure may be an underlying mechanism for the discrepancy between BMD and fracture risk in diabetes. The trabecular bone score has been proposed as an indirect measurement of bone microarchitecture with the routine dual energy absorptiometry. We present a clinical case of diagnosis and treatment of osteoporosis associated with T2DM in patient with a low-trauma fracture and concomitant endocrine disorder.
Loss of P16 in Esophageal Adenocarcinoma Detected by Fluorescence in situ Hybridization and Immunohistochemistry
Authors: Kotzev A. , Kamenova M. 
Published: October 2017

Abstract
Molecular biology of esophageal adenocarcinoma (EAC) is not fully elucidated. The aim of this study was to assess the expression of cycle regulator and tumor suppressor p16 in esophageal adenocarcinoma. The expression of p16 at protein and gene level was investigated using immunohistochemistry and fluorescence in situ hybridization in thirteen EAC specimens obtained by endoscopic biopsies and surgical resections. The mean age of enrolled patients was 62 years and a male predominance was observed. Loss of p16 protein expression was detected in 77% of the cases and loss of p16 gene was found in 69% of cases as hemizygous deletion was the most common. Significant correlation was found between the absence of p16 protein expression and p16 allelic loss. Cell cycle disturbances seem to play role in the EAC carcinogenesis and probably p16 gene deletions are connected with the loss of p16 protein expression.