bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Phosphine‐Free, Heterogeneous Palladium‐Catalyzed Atom‐Efficient Carbonylative Cross‐Coupling of Triarylbismuths with Aryl Iodides: Synthesis of Biaryl Ketones.
Authors: Hao Wenyan , Liu Haiyi , Yin Lin , Cai Mingzhong 
Published: September 2016

AbstractAn efficient Pd‐catalyzed carboxylative cross‐coupling process of aryl iodides with triaryl bismuths in the presence of carbon monoxide at atmospheric pressure is developed to yield a variety of bisaryl ketones.
ChemInform Abstract: Thermodynamically Driven, syn‐Selective Vinylogous Aldol Reaction of Tetronamides.
Authors: Karak Milandip , Barbosa Luiz C. A. , Acosta Jaime A. M. , Sarotti Ariel M. , Boukouvalas John 
Published: September 2016

AbstractThe aldol reaction between N‐monoarylated tetronamides and various aryl, hetaryl or alkyl aldehydes is examined.
ChemInform Abstract: Ni(II)‐Catalyzed C(sp2)—H Alkynylation/Annulation with Terminal Alkynes under an Oxygen Atmosphere: A One‐Pot Approach to 3‐Methyleneisoindolin‐1‐one.
Authors: Zheng Xin‐Xiang , Du Cong , Zhao Xue‐Mei , Zhu Xinju , Suo Jian‐Feng , Hao Xin‐Qi , Niu Jun‐Long , Song Mao‐Ping 
Published: September 2016

AbstractA broad spectrum of amide substituents bearing the removable bidentate directing group ‐Pyo is treated with terminal aromatic acetylenes and the aliphatic analogue (XVIa) to produce the desired ring system, required as framework for the synthesis of alkaloids and bioactive compounds.
ChemInform Abstract: New Chiral Reagent for Installation of Pharmacophoric (S)‐ or (R)‐2‐(Alkoxyphosphono)‐1‐amino‐2,2‐difluoroethyl Groups.
Authors: Xie Chen , Zhang Lijun , Mei Haibo , Pajkert Romana , Ponomarenko Maksym , Pan Yi , Roeschenthaler Gerd‐Volker , Soloshonok Vadim A. , Han Jianlin 
Published: September 2016

AbstractThe title reagent (II) (<95% purity) is used without further purification due to its decomposition during distillation.
ChemInform Abstract: N‐Methyl Transfer Induced Copper‐Mediated Oxidative Diamination of Alkynes.
Authors: Ho Hon Eong , Oniwa Kazuaki , Yamamoto Yoshinori , Jin Tienan 
Published: September 2016

AbstractThis novel intramolecular oxidative diamination of bis(2‐aminophenyl)acetylene results in formation of the π‐conjugated polyheterocyclic scaffold of 5,10‐dihydroindolo[3,2‐b]indoles.
ChemInform Abstract: Syntheses of [1,2,4]Triazolo[1,5‐a]benzazoles Enabled by the Transition‐Metal‐Free Oxidative N—N Bond Formation.
Authors: Shang Erchang , Zhang Junzhi , Bai Jinyi , Wang Zhan , Li Xiang , Zhu Bing , Lei Xiaoguang 
Published: September 2016

AbstractA transition‐metal‐free NCS mediated oxidative N—N bond formation is developed for the efficient syntheses of various 2‐phenyl‐4H‐[1,2,4]triazolo[1,5‐a]benzazoles and analogues.
ChemInform Abstract: Stereocontrolled Construction of Tetrahydropyrano[2,3‐c]pyrazole Scaffold via an Organocatalyzed Formal [3 + 3] Annulation.
Authors: Zheng Yin , Cui Lei , Wang Youming , Zhou Zhenghong 
Published: September 2016

AbstractAn enantioselective formal [3 + 3] annulation of pyrazolinones (I) and Morita—Baylis—Hillman type nitroolefins (II) is developed using a bifunctional squaramide as catalyst.
ChemInform Abstract: Enantioselective Construction of Quaternary Carbon Stereocenter via Palladium‐Catalyzed Asymmetric Allylic Alkylation of Lactones.
Authors: Li Xiao‐Hui , Wan Shi‐Li , Chen Di , Liu Qing Rong , Ding Chang‐Hua , Fang Ping , Hou Xue‐Long 
Published: September 2016

AbstractThe practical method offers access to α,α‐disubstituted six‐membered lactones in high yields.
ChemInform Abstract: Base‐Mediated Regiospecific Cascade Synthesis of N‐(2‐Pyridyl)pyrroles from N‐Propargylic β‐Enaminones.
Authors: Shen Jinhai , Yang Xifa , Wang Fuyuan , Wang Yue , Cheng Guolin , Cui Xiuling 
Published: September 2016

AbstractThe pyrrole and pyridine rings are installed simultaneously under KOH‐mediated mild reaction conditions.
ChemInform Abstract: Visible Light‐Induced Aerobic C—N Bond Activation: A Photocatalytic Strategy for the Preparation of 2‐Arylpyridines and 2‐Arylquinolines.
Authors: Hu Bei , Li Yuyuan , Dong Wuheng , Xie Xiaomin , Wan Jun , Zhang Zhaoguo 
Published: September 2016

AbstractThe title reaction can be achieved by using simple ketones and easily available diamines as substrates with O2 as the sole oxidant.
ChemInform Abstract: Synthesis of Substituted Tetrahydroisoquinolines by Lithiation Then Electrophilic Quench.
Authors: Talk Ruaa A. , Duperray Alexia , Li Xiabing , Coldham Iain 
Published: September 2016

AbstractThe intermediately formed 1‐lithiated derivatives are trapped with diverse electrophiles, thus affording 1‐functionalized tetrahydroisoquinolines in high yields.
ChemInform Abstract: Copper‐Promoted Double Oxidative C—H Amination Cascade for the Synthesis of Imidazo[1,5‐a]quinolines.
Authors: Li Zhong , Wu Song‐Song , Luo Zai‐Gang , Liu Wei‐Kang , Feng Cheng‐Tao , Ma Shi‐Tang 
Published: September 2016

AbstractThe optimized conditions allow the cascade reaction of methylazaarenes and benzylamines to form imidazoquinolines in moderate yields.
ChemInform Abstract: 1,2‐Thiazines: One‐Pot Syntheses Utilizing Mono and Diaza Analogues of Sulfones.
Authors: Bohmann Rebekka Anna , Unoh Yuto , Miura Masahiro , Bolm Carsten 
Published: September 2016

AbstractA one‐pot Michael addition/cyclization/condensation reaction sequence for the regioselective synthesis of 1,2‐thiazines is developed, starting from propargyl ketones and NH‐sulfoximines or NH‐sulfondiimines.
ChemInform Abstract: Facile Assembly of Benzo[b]naphtho[2,3‐d]azocin‐6(5H)‐ones by a Palladium‐Catalyzed Double Carbometalation.
Authors: Gong Xinxing , Chen Mo , Yao Liangqing , Wu Jie 
Published: September 2016

AbstractThe highly efficient tandem reaction delivers polycycles in moderate to high yields.
ChemInform Abstract: ent‐Abietane Diterpenoids with anti‐Neuroinflammatory Activity from the Rare Chloranthaceae Plant Chloranthus oldhamii.
Authors: Xiong Juan , Hong Zhi‐Lai , Xu Peng , Zou Yike , Yu Shang‐Bo , Yang Guo‐Xun , Hu Jin‐Feng 
Published: September 2016

AbstractTwelve new ent‐abietane diterpenoids, chlorabietins A—L, are isolated and fully characterized.
ChemInform Abstract: Concise Synthesis of Dictyoquinazol A via a Dimerisation—Cyclocondensation Sequence.
Authors: Wangsahardja Jonatan , Marcolin Gabriella M. , Lizarme Yuvixza , Morris Jonathan C. , Hunter Luke 
Published: September 2016

AbstractDictyoquinazol A (I) is obtained by a two‐step total synthesis in 19% overall yield.
Adsorption Behavior of Halogenated Anesthetic and Water Vapor on Cr‐Based MOF (MIL‐101) Adsorbent. Part II. Multiple‐Cycle Breakthrough Tests
Authors: Hua Ye , Gargiulo Nicola , Peluso Antonio , Aprea Paolo , Eić Mladen , Caputo Domenico 
Published: September 2016

AbstractMultiple‐cycle breakthrough tests of a binary gas mixture of the halogenated anesthetic sevoflurane (SF) and water vapor were performed on both the synthesized chromium‐based metal organic framework (Cr‐MOF) and a conventionally used reference adsorbent. At 1 vol % SF and 50 % relative humidity mixture composition, the Cr‐MOF (MIL‐101) showed a significantly higher SF adsorption capacity, lower water vapor adsorption capacity, and no roll‐up effect compared to the reference sample. After each adsorption measurement, the saturated column was regenerated. MIL‐101 showed higher stability with minor SF capacity loss after 14 cycles, while the reference sample lost about a half of the SF capacity after 17 cycles.
Influence of Nanoparticles and Drop Size Distributions on the Rheology of w/o Pickering Emulsions
Authors: Hohl Lena , Röhl Susanne , Stehl Dmitrij , von Klitzing Regine , Kraume Matthias 
Published: September 2016

AbstractThe rheological behavior of particle/oil suspensions and w/o Pickering emulsions consisting of water, 1‐dodecene and different fumed silica nanoparticles was investigated. The particles varied in hydrophobicity and specific surface area. The influence of particle concentration and water content on rheology was determined and the emulsion drop size distributions were examined. Emulsions with different drop sizes were created by either varying the particle concentration or the water content. It was found that the particles in the continuous oil phase and not the drop size distribution seem to be the major influencing factor on the Pickering emulsion rheology.
Characteristics of Stable Pickering Emulsions under Process Conditions
Authors: Stehl Dmitrij , Hohl Lena , Schmidt Marcel , Hübner Jessica , Lehmann Maren , Kraume Matthias , Schomäcker Reinhard , von Klitzing Regine 
Published: September 2016

AbstractEmulsions stabilized by solid particles are so called Pickering emulsions which are characterized by their high stability against coalescence. This type of emulsion can be used for a lot of applications. Very little is known about how reaction conditions affect their properties. In this study the influence of important reaction conditions like shear stress, pressure, temperature, and the influence of synthesis gas on Pickering emulsions is investigated. It is shown that the emulsions remain stable in terms of coalescence in a broad range of the reaction conditions and are suitable as reaction media for industrial processes and for a reaction optimization with a subsequent separation step.
Akinesia and freezing caused by Na+ leak‐current channel (NALCN) deficiency corrected by pharmacological inhibition of K+ channels and gap junctions
Authors: Kasap Merve , Bonnett Kendra , Aamodt Eric J. , Dwyer Donard S. 
Published: September 2016

AbstractThe Na+ leak‐current channel (NALCN) regulates locomotion, respiration, and intellectual development. Previous work highlighted striking similarities between characteristic movement phenotypes of NALCN‐deficient animals (Drosophila and Caenorhabditis elegans) and the major symptoms of Parkinson's disease and primary progressive freezing gait. We have discovered novel physiological connections between the NALCN, K+ channels, and gap junctions that mediate regulation of locomotion in C. elegans. Drugs that block K+ channels and gap junctions or that activate Ca++ channels significantly improve movement of NALCN‐deficient animals. Loss‐of‐function of the NALCN creates an imbalance in ions, including K+ and Ca++, that interferes with normal cycles of depolarization–repolarization. This work suggests new therapeutic strategies for certain human movement disorders. J. Comp. Neurol. 525:1109–1121, 2017. © 2016 Wiley Periodicals, Inc.
Patterns and distribution of presynaptic and postsynaptic elements within serial electron microscopic reconstructions of neuronal arbors from the medicinal leech Hirudo verbana
Authors: Pipkin Jason E. , Bushong Eric A. , Ellisman Mark H. , Kristan Jr. William B. 
Published: September 2016

ABSTRACTMicroscale connectomics involves the large‐scale acquisition of high‐resolution serial electron micrographs from which neuronal arbors can be reconstructed and synapses can be detected. In addition to connectivity information, these data sets are also rich with structural information, including vesicle types, number of postsynaptic partners at a given presynaptic site, and spatial distribution of synaptic inputs and outputs. This study uses serial block‐face scanning electron microscopy (EM) to collect two volumes of serial EM data from ganglia of the medicinal leech. For the first volume, we sampled a small fraction of the neuropil belonging to an adult ganglion. From this data set we measured the proportion of arbors that contained vesicles and the types of vesicles contained and developed criteria to identify synapses and to measure the number of apparent postsynaptic partners in apposition to presynaptic boutons. For the second data set, we sampled an entire juvenile ganglion, which included the somata and arbors of all the neurons. We used this data set to placd our findings from mature tissue in the context of fully reconstructed arbors and to explore the spatial distribution of synaptic inputs and outputs on these arbors. We observed that some neurons segregated their arbors into input only and mixed input/output zones, that other neurons contained exclusively mixed input/output zones, and that still others contained only input zones. These results provide the groundwork for future behavioral studies. J. Comp. Neurol. 524:3677–3695, 2016. © 2016 Wiley Periodicals, Inc.
Photophysical Properties of Benzoylgermane and para‐Substituted Derivatives: Substituent Effects on Electronic Transitions
Authors: Feuerstein Wolfram , Höfener Sebastian , Klopper Wim , Lamparth Iris , Moszner Norbert , Barner‐Kowollik Christopher , Unterreiner Andreas‐N. 
Published: September 2016

AbstractIn the present study, a selection of basic substitution patterns on benzoyl(trimethyl)germane was investigated using time‐dependent density‐functional theory (TDDFT) to explore the influence on the stability and on the relative order of the lowest excited electronic states. The theoretical results are in agreement with absorption and fluorescence measurements. We show that electron‐withdrawing groups decrease the energetic level of the lowest singlet and triplet state relative to the electron‐pushing systems resulting in red‐shifted radiative transitions (fluorescence). In the first triplet state electron‐withdrawing groups lead to an increased dissociation barrier and a close approach with the singlet ground state before the transition state in the triplet state is reached, favoring radiationless ground‐state recovery. The results are also in good agreement with empirical concepts of organic chemistry, therefore providing simple rules for synthetic strategies towards tuning the excited‐state properties of benzoylgermanes.
Investigation of Supramolecular Nanofibers Formed from Multicomponent Nucleotide‐Appended Bolaamphiphiles and Heteropolymeric DNA as a Template
Authors: Iwaura Rika , Kanai Yoshikazu , Ohnishi‐Kameyama Mayumi 
Published: September 2016

AbstractA novel DNA‐templated multicomponent self‐assembly of well‐defined, molecular‐level‐controlled nanostructures in aqueous solution is demonstrated by using a thermal cycling procedure. The strategy uses four building blocks comprising 1,18‐nucleotide‐appended bolaamphiphiles (3′‐phosphorylated adenosine, thymidine, guanosine, or cytidine connected to each end of an oligomethylene chain) and a heteropolymeric 58‐mer containing a palindromic sequence as the template DNA. Atomic force microscopic observations, circular dichroism, and temperature‐dependent absorption spectra revealed that the multicomponent self‐assembly of the four nucleotide bolaamphiphiles and template DNA formed right‐handed helical nanofibers with complementary base pairs during thermal cycling. Nanofibers were not formed if one of the four nucleotide bolaamphiphiles was missing, suggesting that construction of the helical nanofiber resulted from self‐assembly of all four bolaamphiphiles to form matched base pairs sorted according to the sequence of the template DNA.
A Mouse Model of Furosemide‐Induced Overactive Bladder
Authors: Saporito Michael S. , Zuvich Eva , DiCamillo Amy 
Published: September 2016

AbstractDetailed in this unit is a mouse model of overactive bladder and urinary incontinence based on diuretic stress‐induced urination. The procedure involves the use of a unique, highly sensitive, and automated urine capturing method to measure urinary latency, frequency, and void volume. Although this method was first described and validated using an anti‐muscarinic drug used for treating overactive bladder, subsequent work has shown that effective non‐cholinergic agents can be detected. These findings indicate good predictive value for this model regarding the possible clinical utility of test agents as treatments for overactive bladder, regardless of their site of action. © 2016 by John Wiley & Sons, Inc.
Measurement of Receptor Signaling Bias
Authors: Kenakin Terry 
Published: September 2016

AbstractG protein–coupled receptors (GPCRs) are often pleiotropically linked to numerous cellular signaling mechanisms in cells, and it is now known that many agonists differentially activate some signaling pathways at the expense of others. The mechanism for this effect is the stabilization of different active receptor states by different agonists, and it leads to varying qualities of efficacy for different agonists. Agonist bias is a powerful mechanism to amplify beneficial signals and diminish harmful signals, and thus improve the overall profile of agonist ligands. This unit describes a method to quantify agonist bias with a scale that enables medicinal chemists to amplify or reduce these effects in new molecules. The method is based on the Black/Leff operational model and yields a statistical estimate of the confidence for bias measurements. © 2016 by John Wiley & Sons, Inc.
Metastatic pancreatic acinar cell carcinoma in a younger male with marked AFP production: A potential pitfall on fine needle aspiration biopsy
Authors: Valente Kari , Yacoub George , Cappellari James O. , Parks Graham 
Published: September 2016

A 30‐year‐old male presented to his doctor with complaints of abdominal pain and was found to have retroperitoneal as well as multiple hepatic masses. A serum alpha‐fetoprotein (AFP) level was significantly elevated (17,373 ng mL−1), raising suspicions for a metastatic germ cell tumor. Fine needle aspiration biopsy of the pancreatic lesion revealed atypical epithelioid cells with round nuclei, large prominent nucleoli, and granular cytoplasm. The morphologic differential diagnosis included pancreatic neoplasm, metastatic germ cell tumor, other metastatic carcinoma, and melanoma. An extensive panel of immunohistochemical stains confirmed the diagnosis of acinar cell carcinoma. The diagnosis of acinar cell carcinoma could be confounded by the markedly increased AFP level, particularly in the setting of a retroperitoneal mass in a younger male. The increased AFP level in the setting of an acinar cell tumor is a potential pitfall to correct diagnosis by cytology. As the treatment for these two entities differs considerably, acute awareness of the phenomenon is important. We present a case of pancreatic ACC with an increased AFP level diagnosed on a cytology specimen. Diagn. Cytopathol. 2017;45:133–136. © 2016 Wiley Periodicals, Inc.
Analysis of novel alleles of brother of tout‐velu, the drosophila ortholog of human EXTL3 using a newly developed FRT42D ovoD chromosome
Authors: Lujan Ernesto , Bornemann Douglas J. , Rottig Carmen , Bayless Brian A. , Stocker Hugo , Hafen Ernst , Arora Kavita , Warrior Rahul 
Published: September 2016

AbstractThe FLP/FRT system permits rapid phenotypic screening of homozygous lethal mutations in the context of a viable mosaic fly. Combining this system with ovoD dominant female‐sterile transgenes enables efficient production of embryos derived from mutant germline clones lacking maternal contribution from a gene of interest. Two distinct sets of FRT chromosomes, carrying either the mini‐white (w + mW.hs), or rosy (ry+) and neomycin (neoR) transgenes are in common use. Parallel ovoD lines were developed using w + mW.hs FRT insertions on the X and chromosomes 2R and 3L, as well as ry+, neoR FRT insertions on 2L and 3R. Consequently, mutations isolated on the X, 2R and 3L chromosomes in a ry+, neoR FRT background, are not amenable to germline clonal analysis without labor‐intensive recombination onto chromosome arms containing a w + mW.hs FRT. Here we report the creation of a new ovoD line for the ry+, neoR FRT insertion at position FRT42D on chromosome 2R, through induced recombination in males. To establish the developmental relevance of this reagent we characterized the maternal‐effect phenotypes of novel brother of tout‐velu alleles generated on an FRT42D chromosome in a somatic mosaic screen. We find that an apparent null mutation that causes severe defects in somatic tissues has a much milder effect on embryonic patterning, emphasizing the necessity of analyzing mutant phenotypes at multiple developmental stages.
Beyond connectedness: why pairwise metrics cannot capture community stability
Authors: Neutel Anje‐Margriet , Thorne Michael A. S. 
Published: September 2016

AbstractThe connectedness of species in a trophic web has long been a key structural characteristic for both theoreticians and empiricists in their understanding of community stability. In the past decades, there has been a shift from focussing on determining the number of interactions to taking into account their relative strengths. The question is: How do the strengths of the interactions determine the stability of a community? Recently, a metric has been proposed which compares the stability of observed communities in terms of the strength of three‐ and two‐link feedback loops (cycles of interaction strengths). However, it has also been suggested that we do not need to go beyond the pairwise structure of interactions to capture stability. Here, we directly compare the performance of the feedback and pairwise metrics. Using observed food‐web structures, we show that the pairwise metric does not work as a comparator of stability and is many orders of magnitude away from the actual stability values. We argue that metrics based on pairwise‐strength information cannot capture the complex organization of strong and weak links in a community, which is essential for system stability.
Crack Suppression of Transparent Protective Layer on Polycarbonate Formed by Fluorine Laser
Authors: OKOSHI MASAYUKI 
Published: September 2016

SUMMARYA transparent, hard silica glass (SiO2) layer was formed on a conventional protective coat made of silicone ([SiO(CH3)2]n) on a polycarbonate plate by the 157 nm fluorine (F2) laser‐induced photochemical modification of silicone into SiO2. Long exposure of the F2 laser to the sample produced cracks on the surface; a metallic mesh mask was set on the sample during F2 laser irradiation to suppress the cracks successfully. As a result, the thickness of the formed SiO2 layer could increase to approximately 1.3 μm without any crack, and the hardness of the sample also increased to approximately 2.8 GPa.
Highly Sensitive Wireless Sensor Node Using Surface Acoustic Wave Devices for Structural Health Monitoring
Authors: BAO ZHONGQIAO , HARA MOTOAKI , KUWANO HIROKI 
Published: September 2016

SUMMARYA wireless node of strain sensor was developed for structural health monitoring. Surface acoustic wave oscillators were used as sensor heads of the system, and can linearly detect the strain of 10−5 to 10−6 order. In the developed sensor node, a mixer chip and communicator were integrated on the board for temperature compensation and construction of sensor mesh network. We practically applied the developed sensor nodes to measurement of the static deformation in the metal plate, and successfully detected the deformation distribution. In this experiment, power consumption of each node was 190 μW in sleep mode and 50 mW in data transmission mode.