bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative proteomics and protein profile related to phenolic compounds and antioxidant activity in germinated Oryza sativa ‘KDML105’ and Thai brown rice ‘Mali Daeng’ for better nutritional value
Authors: Maksup Sarunyaporn , Pongpakpian Sarintip , Roytrakul Sittiruk , Cha‐Um Suriyan , Supaibulwatana Kanyaratt 
Published: June 2017

AbstractBACKGROUNDBrown rice (BR) and germinated brown rice (GBR) are considered as prime sources of carbohydrate and bioactive compounds for more than half of the populations worldwide. Several studies have reported on the proteomics of BR and GBR; however, the proteomic profiles related to the synthesis of bioactive compounds are less well documented. In the present study, BR and GBR were used in a comparative analysis of the proteomic and bioactive compound profiles for two famous Thai rice varieties: Khao Dawk Mali 105 (KDML) and Mali Daeng (MD).RESULTSThe proteomes of KDML and MD revealed differences in the expression patterns of proteins after germination. Total phenolic compound content, anthocyanin contents and antioxidant activity of red rice MD was approximately 2.6‐, 2.2‐ and 9.2‐fold higher, respectively, compared to that of the white rice KDML. Moreover, GBR of MD showed higher total anthocyanin content and greater antioxidant activity, which is consistent with the increase expression of several proteins involved in the biosynthesis of phenolic compounds and protection against oxidative stress.CONCLUSIONRed rice MD exhibits higher nutrient values compared to white rice KDML and the appropriate germination of brown rice could represent a method for improving health‐related benefits. © 2017 Society of Chemical Industry
Sexual Dimorphism in Umbilical Vein Blood Flow During the Second Half of Pregnancy: A Longitudinal Study
Authors: Widnes Christian , Flo Kari , Wilsgaard Tom , Odibo Anthony O. , Acharya Ganesh 
Published: June 2017

ObjectivesTo investigate gestational age–specific serial changes in umbilical vein (UV) volume blood flow during the second half of normal pregnancy and establish sex‐specific reference ranges.MethodsThis work was a prospective longitudinal study of singleton low‐risk pregnancies. The UV diameter and maximum blood flow velocity were serially measured by sonography at the intra‐abdominal portion of the UV over 19 to 41 weeks. Umbilical vein volume blood flow was calculated and normalized for estimated fetal weight.ResultsOne hundred seventy‐nine women and their fetuses (87 male and 92 female) were included in the final analysis, and a total of 746 observations were used to construct sex‐specific reference intervals. We found no statistically significant sex‐specific differences in the UV parameters examined. However, the temporal development patterns of normalized UV volume blood flow appeared to differ between male and female fetuses during the second half of pregnancy, with crossovers at 24 and 32 weeks' gestation.ConclusionsUmbilical vein volume blood flow is similar among male and female fetuses in quantitative terms, but the pattern of gestational age–dependent temporal changes may be different, which may have important physiologic implications with regard to in utero development and maturation of the fetoplacental unit.
Comparison of Oral Contrast‐Enhanced Transabdominal Ultrasound Imaging With Transverse Contrast‐Enhanced Computed Tomography in Preoperative Tumor Staging of Advanced Gastric Carcinoma
Authors: He Xuemei , Sun Jing , Huang Xiaoling , Zeng Chun , Ge Yinggang , Zhang Jun , Wu Jingxian 
Published: June 2017

ObjectivesThis study assessed the diagnostic performance of transabdominal oral contrast‐enhanced ultrasound (US) imaging for preoperative tumor staging of advanced gastric carcinoma by comparing it with transverse contrast‐enhanced computed tomography (CT).MethodsThis retrospective study included 42 patients with advanced gastric cancer who underwent laparoscopy, radical surgery, or palliative surgery because of serious complications and had a body mass index of less than 25 kg/m2. A cereal‐based oral contrast agent was used for transabdominal oral contrast‐enhanced US. Retrospective analyses were conducted using preoperative tumor staging data acquired by either transabdominal oral contrast‐enhanced US or transverse contrast‐enhanced CT. Both contrast‐enhanced US and contrast‐enhanced CT examinations were reviewed by 2 experienced radiologists independently for preoperative tumor staging according to the seventh edition of the TNM classification. The accuracy, sensitivity, and specificity were calculated by comparing the results of contrast‐enhanced US and contrast‐enhanced CT with pathologic findings. The overall accuracies of the imaging modalities were compared by the McNemar test.ResultsNo significant difference was noted in the overall accuracy of transabdominal oral contrast‐enhanced US (86% [36 of 42]) and transverse contrast‐enhanced CT (83% [35 of 42] P > .999). For stage T2 to T4 gastric cancer, the accuracies of transabdominal oral contrast‐enhanced US were 88%, 86%, and 98%, respectively, and those of transverse contrast‐enhanced CT were 93%, 83%, and 90%.ConclusionsThe overall accuracy of transabdominal oral contrast‐enhanced US was comparable with that of transverse contrast‐enhanced CT for preoperative tumor staging of advanced gastric cancer.
Blink R1 latency utility in diagnosis and treatment assessment of polyradiculoneuropathy‐organomegaly‐endocrinopathy‐monoclonal protein‐skin changes and chronic inflammatory demyelinating polyradiculoneuropathy
Authors: Wang Wei , Litchy William J. , Mauermann Michelle L. , Dyck P. James B. , Dispenzieri Angela , Mandrekar Jay , Dyck Peter J. , Klein Christopher J. 
Published: June 2017

ABSTRACTIntroduction: In polyradiculoneuropathy‐organomegaly‐endocrinopathy‐monoclonal protein‐skin changes (POEMS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), limb nerve conduction studies (NCSs) are limited in identifying demyelination and in detecting treatment effects in severely affected patients. Blink R1 latency may improve these assessments. Methods: POEMS and CIDP patients who had undergone NCS and blink reflex were identified. Correlations among R1 latency, limb NCS, and neuropathy impairment scores (NIS) were compared. Results: Among 182 patients (124 POEMS, 58 CIDP) who were identified, R1 prolongation (>13 ms) occurred in 64.3% (65.3% POEMS, 62.1% CIDP). R1 prolongation correlated with more severely affected NCS in both POEMS (ulnar CMAP 2.6 mV vs. 4.5 mV, P = 0.001) and CIDP (2.0 mV vs. 6.1 mV, P < 0.001). In severely affected patients (ulnar CMAP ≤0.5 mV [10%:18/182]), R1 (>13 ms) helped establish demyelination. In 31 patients (16 POEMS, 15 CIDP), the R1 latency changes were concordant with NIS changes in 94% of patients with POEMS and 60% of patients with CIDP. Discussion: Blink R1 latencies are valuable in defining demyelination and detecting improvement in severely affected POEMS and CIDP patients. Muscle Nerve 57: E8–E13, 2018
Compound muscle action potential duration in critical illness neuromyopathy
Authors: Kramer Christopher L. , Boon Andrea J. , Harper C. Michel , Goodman Brent P. 
Published: June 2017

ABSTRACTIntroductionWe sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions.MethodsFifty‐eight patients with CINM who had been seen over a 17‐year period were retrospectively studied. Electrodiagnostic findings of the CINM cohort were compared with patients with axonal peripheral neuropathy and myopathy due to other causes.ResultsMean CMAP durations were prolonged, and mean CMAP amplitudes were severely reduced both proximally and distally in all nerves studied in the CINM cohort relative to the control groups. The specificity of prolonged CMAP durations for CINM approached 100% if they were encountered in more than 1 nerve.DiscussionProlonged, low‐amplitude CMAPs occur more frequently and with greater severity in CINM patients than in neuromuscular controls with myopathy and axonal neuropathy and are highly specific for the diagnosis of CINM. Muscle Nerve 57: 395–400, 2018
Health Care Quality: Measuring Obesity in Performance Frameworks
Authors: Zvenyach Tracy , Pickering Matthew K. 
Published: June 2017

ObjectiveObesity affects over one‐third of Americans and leads to several chronic and costly comorbid conditions. The national movement toward value‐based care calls for a refocusing of efforts to address the US obesity epidemic. To help set the stage, the current landscape of obesity‐specific quality measures was evaluated.MethodsSeven quality measure databases and nine professional societies were searched. Inclusion and exclusion criteria were applied. Measures were then classified by domain and by implementation in national public programs.ResultsEleven obesity‐specific quality measures in adults were identified (nine process and two outcome). Three measures received National Quality Forum (NQF) endorsement. Two measures were actively used within Centers for Medicare and Medicaid Services (CMS) programs. Only one measure was both NQF‐endorsed and used by CMS.ConclusionsLimitations exist with respect to obesity‐specific quality metrics. Such gaps provide opportunities for obesity care specialists to engage and offer valuable insights and pragmatic approaches toward quality measurement.
Preliminary characterization of putative structural cuticular proteins in the malaria vector Anopheles sinensis
Authors: Zhou Dan , Duan Baiyun , Sun Yan , Ma Lei , Zhu Changliang , Shen Bo 
Published: June 2017

AbstractBACKGROUNDThe insect cuticle protects against environmental stresses such as insecticides, physical injury, dehydration and pathogenic microorganisms. Structural cuticular proteins (CPs) are the primary components of the cuticle, and are of interest for physiology‐based pest management methods. Anopheles sinensis CPs are poorly characterised at present, and therefore we performed whole‐genome sequence analysis and re‐analysed available transcriptome data to identify potential insecticide resistance‐associated CPs.RESULTSGenome analysis revealed 238 putative CPs belonging to 11 different families; 136 proteins possessing a Rebers and Riddiford motif (CPR), 12 CPs analogous to peritrophins with a single chitin‐binding domain (CPAP1), eight CPs analogous to peritrophins with three chitin‐binding domains (CPAP3), four proteins with a 44 amino acid motif (CPF), five CPF‐like (CPFL) proteins, nine Tweedle proteins, three proteins of low complexity with alanine residues (CPLCA), 26 proteins of low complexity with conserved glycine residues (CPLCG), seven proteins of low complexity with invariant W residues (CPLCW), 27 proteins of low complexity with proline residues (CPLCP), and one protein with two or three copies of a C‐X ‐C motif (CPCFC). Two CPs belonging to the CPR and CPAP3 families were over‐expressed in a deltamethrin‐resistant strain.CONCLUSIONThese results establish an information framework for An. sinensis CPs that provides a basis for further molecular research. © 2017 Society of Chemical Industry
Sparrow nest survival in relation to prescribed fire and woody plant invasion in a northern mixed‐grass prairie
Authors: Murphy Robert K. , Shaffer Terry L. , Grant Todd A. , Derrig James L. , Rubin Cory S. , Kerns Courtney K. 
Published: June 2017

ABSTRACTPrescribed fire is used to reverse invasion by woody vegetation on grasslands, but managers often are uncertain whether influences of shrub and tree reduction outweigh potential effects of fire on nest survival of grassland birds. During the 2001–2003 breeding seasons, we examined relationships of prescribed fire and woody vegetation to nest survival of clay‐colored sparrow (Spizella pallida) and Savannah sparrow (Passerculus sandwichensis) in mixed‐grass prairie at Des Lacs National Wildlife Refuge in northwestern North Dakota, USA. We assessed relationships of nest survival to 1) recent fire history, in terms of number of breeding seasons (2, 3, or 4–5) since the last prescribed fire, and 2) prevalence of trees and tall (>1.5 m) shrubs in the landscape and of low (≤1.5 m) shrubs within 5 m of nests. Nest survival of both species exhibited distinct patterns related to age of the nest and day of year, but bore no relationship to fire history. Survival of clay‐colored sparrow nests declined as the amount of trees and tall shrubs within 100 m increased, but we found no relationship to suggest nest parasitism by brown‐headed cowbirds (Molothrus ater) as an underlying mechanism. We found little evidence linking nest survival of Savannah sparrow to woody vegetation. Our results suggest that fire can be used to restore northern mixed‐grass prairies without adversely affecting nest survival of ≥2 widespread passerine species. Survival of nests of clay‐colored sparrow may increase when tall woody cover is reduced by fire. Our data lend support to the use of fire for reducing scattered patches of tall woody cover to enhance survival of nests of ≥1 grassland bird species in northern mixed‐grass prairies, but further study is needed that incorporates experimental approaches and assessments of shorter term effects of fire on survival of nests of grassland passerines. © 2017 This article is a U.S. Government work and is in the public domain in the USA.
Lower brain and blood nutrient status in Alzheimer's disease: Results from meta‐analyses
Authors: de Wilde Martijn C. , Vellas Bruno , Girault Elodie , Yavuz Aysun Cetinyurek , Sijben John W. 
Published: June 2017

AbstractIntroductionAlzheimer's disease (AD) patients are at risk of nutritional insufficiencies because of physiological and psychological factors. Recently, we showed the results of the meta‐analyses indicating lower plasma levels of vitamins A, B12, C, E, and folate in AD patients compared with cognitively intact elderly controls (controls). Now, additional and more extensive literature searches were performed selecting studies which compare blood and brain/cerebrospinal fluid (CSF) levels of vitamins, minerals, trace elements, micronutrients, and fatty acids in AD patients versus controls.MethodsThe literature published after 1980 in Cochrane Central Register of Controlled Trials, Medline, and Embase electronic databases was systematically analyzed using Preferred Reporting Items for Systematic reviews and Meta‐Analyses guidelines to detect studies meeting the selection criteria. Search terms used are as follows: AD patients, Controls, vitamins, minerals, trace elements, micronutrients, and fatty acids. Random‐effects meta‐analyses using a linear mixed model with correction for age differences between AD patients and controls were performed when four or more publications were retrieved for a specific nutrient.ResultsRandom‐effects meta‐analyses of 116 selected publications showed significant lower CSF/brain levels of docosahexaenoic acid (DHA), choline‐containing lipids, folate, vitamin B12, vitamin C, and vitamin E. In addition, AD patients showed lower circulatory levels of DHA, eicosapentaenoic acid, choline as phosphatidylcholine, and selenium.ConclusionThe current data show that patients with AD have lower CSF/brain availability of DHA, choline, vitamin B12, folate, vitamin C, and vitamin E. Directionally, brain nutrient status appears to parallel the lower circulatory nutrient status; however, more studies are required measuring simultaneously circulatory and central nutrient status to obtain better insight in this observation. The brain is dependent on nutrient supply from the circulation, which in combination with nutrient involvement in AD‐pathophysiological mechanisms suggests that patients with AD may have specific nutritional requirements. This hypothesis could be tested using a multicomponent nutritional intervention.
Sixth harmonic‐based fault location for VSC‐DC distribution systems
Authors: Li Meng , Jia Ke , Bi Tianshu , Yang Qixun 
Published: June 2017

Accurate fault location methods are of major significance to the line maintenance of voltage source converter (VSC)‐DC distribution systems. However, power electronics change the fault‐characteristics, and the new fault theory is not fully mature. In addition, rapid fault isolation leaves little information for fault location. Fault location for VSC‐DC distribution systems is still a big challenge. The proposed fault location method is developed based on an equivalent feeding‐stage circuit derived herein. The line quantities sixth‐harmonics are used, and an improved discrete Fourier transform algorithm (IDFT) is proposed to remove the influence of both decaying periodic and DC components. Simulation results on PSCAD/EMTDC verified the feasibility of the proposed fault location and IDFT algorithms. Using local measurements with the sampling frequency of 9.6 kHz, the method can locate fault position within 10 ms and with less than 2% error.
Three-dimensional mapping of the local interstellar medium with composite data
Authors: Capitanio L. , Lallement R. , Vergely J. L. , Elyajouri M. , Monreal-Ibero A. 
Published: June 2017

Context. Three-dimensional maps of the Galactic interstellar medium are general astrophysical tools. Reddening maps may be based on the inversion of color excess measurements for individual target stars or on statistical methods using stellar surveys. Three-dimensional maps based on diffuse interstellar bands (DIBs) have also been produced. All methods benefit from the advent of massive surveys and may benefit from Gaia data.
Aims. All of the various methods and databases have their own advantages and limitations. Here we present a first attempt to combine different datasets and methods to improve the local maps.
Methods. We first updated our previous local dust maps based on a regularized Bayesian inversion of individual color excess data by replacing Hipparcos or photometric distances with Gaia Data Release 1 values when available. Secondly, we complemented this database with a series of ≃5000 color excess values estimated from the strength of the λ15273 DIB toward stars possessing a Gaia parallax. The DIB strengths were extracted from SDSS/APOGEE spectra. Third, we computed a low-resolution map based on a grid of Pan-STARRS reddening measurements by means of a new hierarchical technique and used this map as the prior distribution during the inversion of the two other datasets.
Results. The use of Gaia parallaxes introduces significant changes in some areas and globally increases the compactness of the structures. Additional DIB-based data make it possible to assign distances to clouds located behind closer opaque structures and do not introduce contradictory information for the close structures. A more realistic prior distribution instead of a plane-parallel homogeneous distribution helps better define the structures. We validated the results through comparisons with other maps and with soft X-ray data.
Conclusions. Our study demonstrates that the combination of various tracers is a potential tool for more accurate maps. An online tool makes it possible to retrieve maps and reddening estimations.
Does the Surgical Correction of Tibial Torsion with Genu Varum Produce Outcomes Similar to Those in Varus Correction Alone?
Authors: Meade Matthew , Borst Eugene , Nguyen Joseph , Rozbruch S. , Fragomen Austin 
Published: June 2017

AbstractThe aim of this article is to study the relationship between tibia vara and external tibial torsion in adults. The following questions were asked: (1) what is the incidence of rotational deformity in patients with genu varum and (2) do patients who undergo correction of tibial torsion with genu varum have similar outcomes to those who undergo simple tibia vara correction? In this study, 69 patients (138 limbs) underwent bilateral proximal tibial osteotomy for the correction of genu varum. Patients with simple coronal plane deformity (varus alone) were treated with either a monolateral external fixator or a hexapod frame. Those with concomitant external tibial torsion were treated with circular external fixation. The primary outcome was the ability to achieve the desired correction of alignment in the coronal, sagittal, and axial planes. Secondary outcomes included a postoperative Knee Injury and Osteoarthritis Outcome Score (KOOS) and a routine patient satisfaction questionnaire. The incidence of tibial torsion among the entire group of patients with bilateral tibia vara was 46% and overwhelmingly external in direction. The two groups had some significant differences in demographics with torsion patients tending to be younger and thinner. The final mechanical axis deviation and medial proximal tibial angle values for both groups did not differ significantly (p = 0.956). The postcorrection thigh–foot axis was not significantly different between the two groups (p = 0.666). Time to union was not significant (p > 0.999). KOOS was not different between the two groups in symptoms, pain, activities of daily living, and return to sport. There was a difference in the quality of life score between the two groups (p = 0.044). There was no difference between the two groups regarding the patient questionnaire. Based on the finding of this analysis, the incidence of rotational malalignment with genu varum is close to 50%. The recognition of this close association with external tibial torsion deformity may allow for further insights into the role of rotation in varus deformity-related knee pathology and treatment. Patients can expect nearly identical outcomes from this surgery.
Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma to Enhance Osseous Integration Potential for Osteochondral Allografts
Authors: Baumann Charles , Stannard James , Cook James , Stoker Aaron 
Published: June 2017

AbstractFresh osteochondral allograft (OCA) transplantation is an attractive treatment option for symptomatic articular cartilage lesions in young, healthy patients. Since a lack of OCA bone integration can be a cause of treatment failure, methods for speeding and enhancing OCA bone integration to mitigate this potential complication are highly desirable. This study sought to determine and compare the potential of bone marrow aspirate concentrate (BMC) and leukoreduced platelet rich plasma (PRP) to repopulate the osseous portion of an OCA with cells and deliver osteogenic proteins. It was hypothesized that BMC would have significantly higher colony forming units (CFUs)/mL and seed the osseous portion of OCA with more cells than PRP. Finally, we hypothesized that the media of BMC and PRP treated OCAs would have significantly higher concentrations of osteogenic proteins compared with negative control OCAs. Cylindrical OCAs (n = 36) created from tissue stored for 21 days were treated with BMC (n = 12) or PRP (n = 12) obtained for 6 dogs, or left untreated as a negative control (n = 12). After treatment, OCAs were cultured for 7 or 14 days. Media were collected for analysis of osteogenic biomarker concentration. Samples of each BMC and PRP were tested for CFU concentration. On day 7 or 14, the grafts were assessed for cell surface adhesion and penetration using fluorescent microscopy. Significant differences in CFU and media biomarker concentration between the groups were determined using one-way analysis of variance (ANOVA) and Tukey's post-hoc test with the significance set at p < 0.05. Only OCAs saturated with BMC had viable cells detectable on the osseous portion of the allografts at day 7 and 14 of culture. BMC samples had a significantly higher (p = 0.029) CFU/mL compared with PRP samples. At day 3 and/or 7 of culture, the concentration of several osteogenic proteins was significantly higher in both BMC and PRP samples. Autogenous BMC can be used to deliver both a cell population and osteogenic proteins that may improve healing of the osseous portion of the OCA clinically.