bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agglomeration effect and the “dual-format” e-marketplace pricing scheme
Authors: Su Ping , Liu Shuguang , Lin Jun 
Published: March 2017

Purpose
This paper aims to study a dominant e-retailer operating its own e-marketplace (B2C) to host peer competitor as well as acting as a traditional retailer (“dual-format” retailing as in Mantin and Krishnan 2014). The dominant retailer offers a two-part tariff charging scheme to a third-party seller. The seller decides whether to join the e-marketplace. The present paper is interested in addressing the following questions: What is the pricing equilibrium before/after the formation of the e-marketplace? What will be the “optimal” charging scheme? What is the impact on the e-marketplace operator if the third-party seller has the option to become “featured”.

Design/methodology/approach
This paper adopts a stylized model to capture the competition between the two retailers and applies game theory to solve the pricing equilibrium. The authors model the dual-format retailing in a two-stage decision: Stage 1, the e-marketplace operator offers a two-part tariff; Stage 2, if the other retailer is participating, they engage in a pricing competition. They assume that the e-marketplace operator is a profit maximizer by choosing its charging scheme subject to the condition that the participating retailer is no worse off.

Findings
The authors find that the e-retailer and the third-party seller in the e-marketplace are not always hurt by intensified price competition. They identify conditions under which higher expected prices are charged as a result of agglomeration effect. The authors’ model also provides theoretical evidence on this popular charging scheme, and shows the feasible region in which the e-marketplace operator could allocate the surplus resulted from the formation of the e-marketplace between itself and the participating retailer. Finally, the authors demonstrate that if the third-party seller has the option to become a “featured” retailer (He and Chen, 2006), it can be detrimental to the e-marketplace operator.

Originality/value
This work is different in three ways: First, the authors model an e-marketplace adopting a “dual-format” retailing, facing the trade-off between its direct retailing revenue and the rents collected from the member store, while the literature mainly focuses on e-marketplaces playing the intermediary role. Second, they explicitly model the “market expansion effect” caused by the agglomeration after the formation of the e-marketplace. The present study complements this stream of research by investigating and providing theoretical evidence on the charging scheme popularly adopted by the e-marketplaces and proposes ways to share the surplus to the participating store.
A Critical View on Human Mobility in Times of Crisis
Authors: Fröhlich Christiane 
Published: March 2017

AbstractThe number of forced migrants from the Global South to the Global North has increased in recent years, contributing to an on‐going, multi‐level political crisis in an already struggling European Union, as well as to a rise in right‐wing populism across the ‘Northern’/’Western’ world. How does the West's claim to be a norm entrepreneur for rule of law, freedom and prosperity relate to a growing rejection of an ‘other’ who is asking for refuge in this protected space in accordance with the latter's self‐proclaimed rules? This contribution aims to answer this question by inquiring into the role of colonial borders, both in the literal and the metaphorical sense, in and for processes of ‘othering’ with regard to present‐day migrants. Inspired by Homi K. Bhabha, it uncovers colonial power relations by looking at central characteristics of Western discourses on migration in order to answer the question of who belongs, which is, in turn, key to peaceful co‐existence.
The Effects of Agricultural R&D on Chinese Agricultural Productivity Growth: New Evidence of Convergence and Implications for Agricultural R&D Policy
Authors: Zhan Jintao , Tian Xu , Zhang Yanyuan , Yang Xinglong , Qu Zhongqiong , Tan Tao 
Published: March 2017

This article measures and compares the effects of agricultural research and development (R&D) on total agricultural factor productivity growth for 29 Chinese provinces from 1986 to 2011. Using the convergence test proposed by Phillips and Sul (), the study finds strong evidence of convergence in total agricultural productivity growth and positive correlation between growth and public investment in R&D. The analysis of convergence indicates that the productivity gap between different regions in China has lessened, suggesting agricultural productivity is convergent across all provinces in China. We find R&D being statistically and economically more important in technological catch‐up than in innovation. Human capital also plays a major role in productivity growth. The finding of strong positive inter‐region spillover effects implies that expanding cooperation across regions for public agricultural research is more efficient and training of researchers can improve total factor productivity, especially in less productive regions.Cet article mesure et compare les effets de la recherche et du développement agricoles sur la progression de la productivité totale des facteurs agricoles au sein de 29 provinces chinoises de 1986 à 2011. Au moyen du test de convergence proposé par Phillips et Sul (), l′étude révèle des preuves manifestes de convergence de la croissance de productivité agricole totale ainsi qu'une corrélation positive entre cette progression et les investissements publics en recherche et en développement. L'analyse de convergence démontre la diminution de l′écart de productivité dans les régions de la Chine, suggérant la convergence de la productivité agricole à la grandeur des provinces chinoises. La recherche et le développement sont ainsi proposés comme étant statistiquement et économiquement plus importants dans le rattrapage technologique que l'innovation. Le capital humain joue aussi un rôle majeur dans la croissance de la productivité. Les forts effets positifs de débordement entre les régions laissent entendre que la coopération grandissante en recherche agricole publique à travers les régions s'avère plus efficace, et que la formation des chercheurs peut améliorer la productivité totale des facteurs, surtout dans les régions moins productives.
The Impact of Market Structure on Ex‐Dividend Day Stock Price Behavior
Authors: Mortal Sandra , Paudel Shishir , Silveri Sabatino (Dino) 
Published: March 2017

AbstractWe explore the impact of market structure on the ex‐day price anomaly. Measuring the price‐drop ratio (PDR) as the ratio of the price change on the ex‐day to the dividend amount, we find that the average NASDAQ PDR is significantly less than one and significantly less than the New York Stock Exchange (NYSE) PDR. We then investigate a subset of firms that voluntary switch from NASDAQ to the NYSE and find that the PDR significantly increases after the switch, suggesting that market structure affects PDRs. We also create a matched sample and find that the NASDAQ PDR converges toward its matched NYSE counterpart, particularly after the introduction of SuperMontage. Our evidence is consistent with significant NASDAQ market structure changes reducing execution cost differences between the two exchanges and, in turn, reducing the PDR difference. Overall, our results highlight the important role market structure can play in understanding anomalies.
Treatment of PBC—A step forward
Authors: Carbone Marco , Invernizzi Pietro 
Published: March 2017

AbstractRecent years have seen a growing interest in PBC within the scientific community, healthcare providers and industries, coupled with great advances in the understanding of the molecular and genetic basis and the natural history of the disease. Several disease‐modifying agents targeting the immune‐mediated response and bile‐acid therapies are at different stages of development, some with promising results. A new drug, obeticholic acid, has been recently registered in the US and Europe as a second‐line treatment in refractory PBC. International cohort studies have highlighted a disease heterogeneity, and so the need to provide patients with a more personalised management based on their risk of disease progression. Major challenges remain the development of surrogate endpoints in clinical trials acceptable to regulatory authorities, in a disease with a relatively low rate of events; and the development of clinical tools for patient's risk stratification and selection of those with greatest potential benefit from second‐line therapies.
Minute Virus of Canines NP1 Protein Governs the Expression of a Subset of Essential Nonstructural Proteins via Its Role in RNA Processing
Authors: Fasina Olufemi O. , Stupps Stephanie , Figueroa-Cuilan Wanda , Pintel David J. 
Published: March 2017

ABSTRACT
Parvoviruses use a variety of means to control the expression of their compact genomes. The bocaparvovirus minute virus of canines (MVC) encodes a small, genus-specific protein, NP1, which governs access to the viral capsid gene via its role in alternative polyadenylation and alternative splicing of the single MVC pre-mRNA. In addition to NP1, MVC encodes five additional nonstructural proteins (NS) that share an initiation codon at the left end of the genome and which are individually encoded by alternative multiply spliced mRNAs. We found that three of these proteins were encoded by mRNAs that excise the NP1-regulated MVC intron immediately upstream of the internal polyadenylation site, (pA)p, and that generation of these proteins was thus regulated by NP1. Splicing of their progenitor mRNAs joined the amino termini of these proteins to the NP1 open reading frame, and splice site mutations that prevented their expression inhibited virus replication in a host cell-dependent manner. Thus, in addition to controlling capsid gene access, NP1 also controls the expression of three of the five identified NS proteins via its role in governing MVC pre-mRNA splicing.

IMPORTANCE
The
Parvovirinae
are small nonenveloped icosahedral viruses that are important pathogens in many animal species, including humans. Minute virus of canine (MVC) is an autonomous parvovirus in the genus
Bocaparvovirus
. It has a single promoter that generates a single pre-mRNA. NP1, a small genus-specific MVC protein, participates in the processing of this pre-mRNA and so controls capsid gene access via its role in alternative internal polyadenylation and splicing. We show that NP1 also controls the expression of three of the five identified NS proteins via its role in governing MVC pre-mRNA splicing. These NS proteins together are required for virus replication in a host cell-dependent manner.
Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells
Authors: Maeda Fumio , Arii Jun , Hirohata Yoshitaka , Maruzuru Yuhei , Koyanagi Naoto , Kato Akihisa , Kawaguchi Yasushi 
Published: March 2017

ABSTRACTUpon herpes simplex virus 1 (HSV-1) infection, the CD98 heavy chain (CD98hc) is redistributed around the nuclear membrane (NM), where it promotes viral de-envelopment during the nuclear egress of nucleocapsids. In this study, we attempted to identify the factor(s) involved in CD98hc accumulation and demonstrated the following: (i) the null mutation of HSV-1 UL34 caused specific dispersion throughout the cytoplasm of CD98hc and the HSV-1 de-envelopment regulators, glycoproteins B and H (gB and gH); (ii) as observed with CD98hc, gB, and gH, wild-type HSV-1 infection caused redistribution of the endoplasmic reticulum (ER) markers calnexin and ERp57 around the NM, whereas the UL34-null mutation caused cytoplasmic dispersion of these markers; (iii) the ER markers colocalized efficiently with CD98hc, gB, and gH in the presence and absence of UL34 in HSV-1-infected cells; (iv) at the ultrastructural level, wild-type HSV-1 infection caused ER compression around the NM, whereas the UL34-null mutation caused cytoplasmic dispersion of the ER; and (v) the UL34-null mutation significantly decreased the colocalization efficiency of lamin protein markers of the NM with CD98hc and gB. Collectively, these results indicate that HSV-1 infection causes redistribution of the ER around the NM, with resulting accumulation of ER-associated CD98hc, gB, and gH around the NM and that UL34 is required for ER redistribution, as well as for efficient recruitment to the NM of the ER-associated de-envelopment factors. Our study suggests that HSV-1 induces remodeling of the global ER architecture for recruitment of regulators mediating viral nuclear egress to the NM.IMPORTANCEThe ER is an important cellular organelle that exists as a complex network extending throughout the cytoplasm. Although viruses often remodel the ER to facilitate viral replication, information on the effects of herpesvirus infections on ER morphological integrity is limited. Here, we showed that HSV-1 infection led to compression of the global ER architecture around the NM, resulting in accumulation of ER-associated regulators associated with nuclear egress of HSV-1 nucleocapsids. We also identified HSV-1 UL34 as a viral factor that mediated ER remodeling. Furthermore, we demonstrated that UL34 was required for efficient targeting of these regulators to the NM. To our knowledge, this is the first report showing that a herpesvirus remodels ER global architecture. Our study also provides insight into the mechanism by which the regulators for HSV-1 nuclear egress are recruited to the NM, where this viral event occurs.
A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly PotentIn Vitro,Ex Vivo, andIn VivoAntiviral Activity
Authors: Chong Huihui , Xue Jing , Xiong Shengwen , Cong Zhe , Ding Xiaohui , Zhu Yuanmei , Liu Zixuan , Chen Ting , Feng Yifan , He Lei , Guo Yan , Wei Qiang , Zhou Yusen , Qin Chuan , He Yuxian 
Published: March 2017

ABSTRACTPeptides derived from the C-terminal heptad repeat (CHR) region of the human immunodeficiency virus type 1 (HIV-1) fusogenic protein gp41 are potent viral entry inhibitors, and currently, enfuvirtide (T-20) is the only one approved for clinical use; however, emerging drug resistance largely limits its efficacy. In this study, we generated a novel lipopeptide inhibitor, named LP-19, by integrating multiple design strategies, including an N-terminal M-T hook structure, an HIV-2 sequence, intrahelical salt bridges, and a membrane-anchoring lipid tail. LP-19 showed stable binding affinity and highly potent, broad, and long-lasting antiviral activity. Inin vitrostudies, LP-19 efficiently inhibited HIV-1-, HIV-2-, and simian immunodeficiency virus (SIV)-mediated cell fusion, viral entry, and infection, and it was highly active against diverse subtypes of primary HIV-1 isolates and inhibitor-resistant mutants.Ex vivostudies demonstrated that LP-19 exhibited dramatically increased anti-HIV activity and an extended half-life in rhesus macaques. In short-term monotherapy, LP-19 reduced viral loads to undetectable levels in acutely and chronically simian-human immunodeficiency virus (SHIV)-infected monkeys. Therefore, this study offers an ideal HIV-1/2 fusion inhibitor for clinical development and emphasizes the importance of the viral fusion step as a drug target.IMPORTANCEThe peptide drug T-20 is the only viral fusion inhibitor in the clinic, which is used for combination therapy of HIV-1 infection; however, it requires a high dosage and easily induces drug resistance, calling for a new drug with significantly improved pharmaceutical profiles. Here, we have developed a short-lipopeptide-based fusion inhibitor, termed LP-19, which mainly targets the conserved gp41 pocket site and shows highly potent inhibitory activity against HIV-1, HIV-2, and even SIV isolates. LP-19 exhibits dramatically increased antiviral activity and an extended half-life in rhesus macaques, and it has potent therapeutic efficacy in SHIV-infected monkeys, highlighting its high potential as a new viral fusion inhibitor for clinical use.
Emergency medicine: what keeps me, what might lose me? A narrative study of consultant views in Wales
Authors: James Ffion , Gerrard Frances 
Published: March 2017

EDs are currently under intense pressure due to increased patient demand. There are major issues with retention of senior personnel, making the specialty a less attractive choice for junior doctors. This study aims to explore what attracted EM consultants to their career and keeps them there. It is hoped this can inform recruitment strategies to increase the popularity of EM to medical students and junior doctors, many of whom have very limited EM exposure.MethodsSemistructured interviews were conducted with 10 consultants from Welsh EDs using a narrative approach.ResultsThree main themes emerged that influenced the career choice of the consultants interviewed: (1) early exposure to positive EM role models; (2) non-hierarchical team structure; (3) suitability of EM for flexible working. The main reason for consultants leaving was the pressure of work impacting on patient care.ConclusionThe study findings suggest that EM consultants in post are positive about their careers despite the high volume of consultant attrition. This study reinforces the need for dedicated undergraduate EM placements to stimulate interest and encourage medical student EM aspirations. Consultants identified that improving the physical working environment, including organisation, would increase their effectiveness and the attractiveness of EM as a long-term career.
DualBlink
Authors: Dementyev Artem , Holz Christian 
Published: March 2017

Increased visual attention, such as during computer use leads to less blinking, which can cause dry eyes—the leading cause of computer vision syndrome. As people spend more time looking at screens on mobile and desktop devices, computer vision syndrome is becoming epidemic in today's population, leading to blurry vision, fatigue, and a reduced quality of life.
One way to alleviate dry eyes is increased blinking. In this paper, we present a series of glasses-mounted devices that track the wearer's blink rate and, upon absent blinks, trigger blinks through actuation: light flashes, physical taps, and small puffs of air near the eye. We conducted a user study to evaluate the effectiveness of our devices and found that air puff and physical tap actuations result in a 36% increase in participants’ average blink rate. Air puff thereby struck the best compromise between effective blink actuations and low distraction ratings from participants. In a follow-up study, we found that high intensity, short puffs near the eye were most effective in triggering blinks while receiving only low-rated distraction and invasiveness ratings from participants. We conclude this paper with two miniaturized and self-contained DualBlink prototypes, one integrated into the frame of a pair of glasses and the other one as a clip-on for existing glasses. We believe that DualBlink can serve as an always-available and viable option to treat computer vision syndrome in the future.
IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells
Authors: Camelo Ana , Rosignoli Guglielmo , Ohne Yoichiro , Stewart Ross A. , Overed-Sayer Catherine , Sleeman Matthew A. , May Richard D. 
Published: March 2017

Key Points
IL-25, IL-33, and TSLP induce distinct activation profiles in ILC2s. IL-2 further amplifies their response and induces an NK-like phenotype. ILC2 plasticity is observed in serum-free media even when in the presence of IL-25, IL-33, and TSLP, and absence of either IL-1β or IL-12.
Individual Patient-Level Meta-Analysis of the Performance of the Decipher Genomic Classifier in High-Risk Men After Prostatectomy to Predict Development of Metastatic Disease
Authors: Spratt Daniel E. , Yousefi Kasra , Deheshi Samineh , Ross Ashley E. , Den Robert B. , Schaeffer Edward M. , Trock Bruce J. , Zhang Jingbin , Glass Andrew G. , Dicker Adam P. , Abdollah Firas , Zhao Shuang G. , Lam Lucia L.C. , du Plessis Marguerite , Choeurng Voleak , Haddad Zaid , Buerki Christine , Davicioni Elai , Weinmann Sheila , Freedland Stephen J. , Klein Eric A. , Karnes R. Jeffrey , Feng Felix Y. 
Published: March 2017

Purpose To perform the first meta-analysis of the performance of the genomic classifier test, Decipher, in men with prostate cancer postprostatectomy. Methods MEDLINE, EMBASE, and the Decipher genomic resource information database were searched for published reports between 2011 and 2016 of men treated by prostatectomy that assessed the benefit of the Decipher test. Multivariable Cox proportional hazards models fit to individual patient data were performed; meta-analyses were conducted by pooling the study-specific hazard ratios (HRs) using random-effects modeling. Extent of heterogeneity between studies was determined with the I2 test. Results Five studies (975 total patients, and 855 patients with individual patient-level data) were eligible for analysis, with a median follow-up of 8 years. Of the total cohort, 60.9%, 22.6%, and 16.5% of patients were classified by Decipher as low, intermediate, and high risk, respectively. The 10-year cumulative incidence metastases rates were 5.5%, 15.0%, and 26.7% ( P < .001), respectively, for the three risk classifications. Pooling the study-specific Decipher HRs across the five studies resulted in an HR of 1.52 (95% CI, 1.39 to 1.67; I2 = 0%) per 0.1 unit. In multivariable analysis of individual patient data, adjusting for clinicopathologic variables, Decipher remained a statistically significant predictor of metastasis (HR, 1.30; 95% CI, 1.14 to 1.47; P < .001) per 0.1 unit. The C-index for 10-year distant metastasis of the clinical model alone was 0.76; this increased to 0.81 with inclusion of Decipher. Conclusion The genomic classifier test, Decipher, can independently improve prognostication of patients postprostatectomy, as well as within nearly all clinicopathologic, demographic, and treatment subgroups. Future study of how to best incorporate genomic testing in clinical decision-making and subsequent treatment recommendations is warranted.
Variation in the effectiveness of insecticide treated nets against malaria and outdoor biting by vectors in Kilifi, Kenya
Authors: Kamau Alice , Mwangangi Joseph M. , Rono Martin K. , Mogeni Polycarp , Omedo Irene , Midega Janet , Scott J. Anthony G. , Bejon Philip 
Published: March 2017

Background: Insecticide treated nets (ITNs) protect humans against bites from the Anopheles mosquito vectors that transmit malaria, thereby reducing malaria morbidity and mortality. It has been noted that ITN use leads to a switch from indoor to outdoor feeding among these vectors. It might be expected that outdoor feeding would undermine the effectiveness of ITNs that target indoors vectors, but data are limited. Methods: We linked homestead level geospatial data to clinical surveillance data at a primary healthcare facility in Kilifi County in order to map geographical heterogeneity in ITN effectiveness and observed vector feeding behaviour using landing catches and CDC light traps in seven selected areas of high and low ITN effectiveness. Results: We observed 33% and 39% visits associated with positive malaria slides among ITN users and non-ITN-users, respectively; ITN use was associated with 22% protection from malaria (crude OR = 0.78, 95% CI: 0.72, 0.84). We obtained significant modification of ITN effectiveness by geographical area (p=0.022), and identified significant hotspots using the spatial scan statistic. Most biting occurred outdoors (62%) and was by An. funestus (76%), and appeared to be more frequent in low ITN effectiveness areas compared with high ITN effectiveness areas (69% vs. 26%, p<0.001), but this was due to a single outlying area. After excluding this outlying area, outdoor biting was similar in low vs. high ITN effectiveness area (69% vs. 75%, p=0.76). Conclusion: Our data therefore do not support the hypothesis that outdoor biting undermines the effectiveness of ITNs in our study area.