bluuebunny/crossref_metadata_2025_split huggingface dataset:
High incidence of FXI deficiency in a Spanish town caused by 11 different mutations and the first duplication of F11: Results from the Yecla study
Authors: Esteban J. , de la Morena‐Barrio M. E. , Salloum‐Asfar S. , Padilla J. , Miñano A. , Roldán V. , Soria J. M. , Vidal F. , Corral J. , Vicente V. 
Published: September 2017

IntroductionFactor XI (FXI) deficiency is a rare disorder with molecular heterogeneity in Caucasians but relatively frequent and molecularly homogeneous in certain populations.AimTo characterize FXI deficiency in a Spanish town of 60 000 inhabitants.MethodsA total of 324 764 APTT tests were screened during 20 years. FXI was evaluated by FXI:C and by Western blot. Genetic analysis of F11 was performed by sequencing, multiplex ligation‐dependent probe amplification and genotyping.ResultsOur study identified 46 unrelated cases and 170 relatives with FXI deficiency carrying 12 different genetic defects. p.Cys56Arg, described as founder mutation in the French‐Basque population, was identified in 109 subjects from 24 unrelated families. This mutation was also identified in 2% of the general population. p.Cys416Tyr, c.1693G>A and p.Pro538Leu were identified in 7, 6 and 2 unrelated families, respectively. NGS analysis of the whole F11 gene revealed a common haplotype for each of the four recurrent mutations, suggesting a founder effect. The analysis of plasma FXI of four p.Pro538Leu homozygous carriers revealed that this variant was not activated by FXIIa. We identified four mutations previously described in other Caucasian subjects with FXI deficiency (p.Lys536Asn; p.Thr322Ile, p.Arg268Cys and c.325G>A) and four new gene defects: p.(Cys599Tyr) potentially causing a functional deficiency, p.(Ile426Thr), p.(Ile592Thr) and the first worldwide duplication of 1653 bp involving exons 8 and 9. Bleeding was rare and mild.ConclusionsOur population‐cohort study supplies new evidences that FXI deficiency in Caucasians is more common than previously thought and confirmed the wide underlying genetic heterogeneity, caused by both recurrent and sporadic mutations.
Temporal variation in constitutive and inducible heat shock proteins in the Zebra Finch Taeniopygia guttata
Authors: Finger J. W. , Hoffman A. J. , Wada H. 
Published: September 2017

Cellular stressors initiate the heat shock response mediated by heat shock proteins (HSPs). There are two main types of HSPs, constitutive (always expressed) and inducible (upon stress), but as many in vivo studies fail to distinguish between them and because temporal expression patterns often differ among various types of HSPs, it is unclear when to measure HSPs. In this study, 26 (13 per treatment) adult female Zebra Finches Taeniopygia guttata were heat‐stressed (39 °C) or placed in a control brooder (room temperature) for 3 h and were bled 1 week prior to and at 1, 2, 4, 6 and 20 h post‐treatment. Treatment had no effect on levels of either constitutive HSP70 or inducible HSP90, but both HSPs decreased with time relative to baseline, suggesting a possible effect of handling stress and/or circadian variation.
The influence of other comprehensive income on discretionary expenditures
Authors: Graham Roger C. , Lin K.C. 
Published: September 2017

AbstractOther comprehensive income items (OCI) increase and decrease book value and therefore indicate more or less firm value. It follows that OCI items, albeit transitory, may contribute to a wealth effect that influences expenditure decisions. In support, our regression results indicate an association between current year OCI and future discretionary financing, investing, and operating expenditures. However, we also find that OCI‐influenced expenditures are not associated with future profitability, suggesting such expenditures are not value creating. In further tests, we find that future discretionary expenditures are associated with both positive OCI and negative OCI for higher leveraged firms but only associated with positive OCI for lower leveraged firms. These results suggest that, for highly leveraged firms, positive OCI loosens debt constraints on future expenditures while negative OCI tightens debt constraints on future expenditures. For firms without debt constraints the results are suggestive of possible wealth transfers from debtholders to shareholders.
Potential natural vegetation and pre‐anthropic pollen records on the Azores Islands in a Macaronesian context
Authors: Rull Valentí , Connor Simon E. , Elias Rui B. 
Published: September 2017

AbstractThis paper discusses the concept of potential natural vegetation (PNV) in the light of the pollen records available to date for the Macaronesian biogeographical region, with emphasis on the Azores Islands. The classical debate on the convenience or not of the PNV concept has been recently revived in the Canary Islands, where pollen records of pre‐anthropic vegetation seemed to strongly disagree with the existing PNV reconstructions. Contrastingly, more recent PNV model outputs from the Azores Islands show outstanding parallelisms with pre‐anthropic pollen records, at least in qualitative terms. We suggest the development of more detailed quantitative studies to compare these methodologies as an opportunity for improving the performance of both. PNV modelling may benefit by incorporating empirical data on past vegetation useful for calibration and validation purposes, whereas palynology may improve past reconstructions by minimizing interpretative biases linked to differential pollen production, dispersal and preservation.
Ice sheets and genetics: Insights into the phylogeography of Scottish Atlantic salmon, Salmo salar L.
Authors: Cauwelier Eef , Verspoor Eric , Coulson Mark W. , Armstrong Anja , Knox David , Stradmeyer Lee , Webster Lucy M.I. , Gilbey John 
Published: September 2017

AbstractAimWe constructed an independent phylogeographical hypothesis (IPH) for Atlantic salmon (Salmo salar L.) in Scotland and adjacent northern England and tested if the distribution of contemporary microsatellite variation accorded with the IPH.LocationNW Europe.MethodsKnowledge of post‐Last Glacial Maximum (LGM) landscape development and salmon biology were used to define a temporal sequence of late Quaternary ecological niche models and, combined with the central‐marginal (CM) model of diversity evolution, to formulate an IPH. Observed microsatellite locus variation for salmon from 102 rivers in Scotland and northern England was tested for agreement with the IPH.ResultsThe IPH postulated (1) initial colonization (c. 17 ka bp) of multiple isolated deglaciating coastal regions by long‐distance dispersal, predominantly from SW Europe via the Atlantic, (2) intra‐region colonization dominated by local range expansion, (3) differentiation by founder effects/genetic drift, in line with CM, until deglaciation complete and regions merged (c. 10 ka bp). IPH regions were weakly but significantly differentiated, showed broad agreement with genetically defined regions, and genetic diversity within them positively correlated with time post‐deglaciation, conforming to the CM model. The greatest differentiation was seen for the most recently diverged populations, with evidence that accumulating homoplastic mutations muted older regional phylogeographical signatures.Main conclusionsMicrosatellite differentiation in Scottish Atlantic salmon is significantly but weakly conditioned by post‐LGM deglaciation, with a mosaic of regional groups and a temporal cascade of within‐region CM effects caused by local range expansion as patches became deglaciated. Colonization was predominantly or exclusively from the south‐western European LGM refugium. Accumulating homoplastic mutations have increasingly reduced regional differentiation.
Contests with endogenous deadlines
Authors: Seel Christian 
Published: September 2017

AbstractThis paper analyzes the problem of a contest designer who chooses a starting time and a deadline of the contest to maximize discounted total effort by the contestants. Each contestant secretly decides how much effort to exert between the starting time and the deadline. At the deadline, the contestant who exerted most effort wins a prize, which consists of the endowment of the designer and collected interest. The contest has a unique Nash equilibrium. In the main model, the designer should announce the contest immediately with a short deadline to promote intense competition. I analyze how the optimal starting time and deadline change for a variable contest prize, different types of asymmetries, a Tullock lottery contest success function, and different goal functions of the designer.
Differences in salivary secretory function between patients with erosive esophagitis and those with nonerosive reflux disease
Authors: Manabe Noriaki , Haruma Ken , Kusunoki Hiroaki , Kamada Tomoari , Hata Jiro 
Published: September 2017

AbstractBackground and AimIt has been speculated that impaired salivary flow contributes to abnormal acid clearance in patients with erosive esophagitis (EE). For easy and objective assessment of salivary function, we developed a salivary gland blood flow measurement technique using continuous‐wave Doppler sonography. In the present study, we evaluated the salivary secretory function in patients with EE and those with nonerosive reflux disease (NERD) using this method.MethodsDoppler waveform analysis was performed on the facial artery to assess blood inflow to the submandibular gland of 30 healthy subjects (HS). Blood flow was compared before and after secretory stimulation with 1 mL of lemon juice. Saliva was simultaneously collected and weighed before and after stimulation. Continuous‐wave Doppler sonography was also performed in patients with EE and NERD. The size of the submandibular gland was compared in 26 patients with EE, 41 patients with NERD, and 86 HS.ResultsThe submandibular gland blood flow increased after stimulation in all HS. Both within‐day and day‐to‐day reproducibility were good. There was a significant correlation between the percent increase in the maximum velocity and the percent increase in salivary secretion. Although the size of the submandibular gland was not significantly different among the three groups, the percent increase in the maximum velocity in patients with EE was significantly smaller than that in HS.ConclusionsWe have established an easy method of assessing salivary function in daily practice. This study revealed that a decrease in salivary secretory function is involved in the pathology of EE.
National Structural Survey of Veterans Affairs Home‐Based Primary Care Programs
Authors: Karuza Jurgis , Gillespie Suzanne M. , Olsan Tobie , Cai Xeuya , Dang Stuti , Intrator Orna , Li Jiejin , Gao Shan , Kinosian Bruce , Edes Thomas 
Published: September 2017

ObjectivesTo describe the current structural and practice characteristics of the Department of Veterans Affairs (VA) Home‐Based Primary Care (HBPC) program.DesignWe designed a national survey and surveyed HBPC program directors on‐line using REDCap.ParticipantsWe received 236 surveys from 394 identified HBPC sites (60% response rate).MeasurementsHBPC site characteristics were quantified using closed‐ended formats.ResultsHBPC program directors were most often registered nurses, and HBPC programs primarily served veterans with complex chronic illnesses that were at high risk of hospitalization and nursing home care. Primary care was delivered using interdisciplinary teams, with nurses, social workers, and registered dietitians as team members in more than 90% of the sites. Most often, nurse practitioners were the principal primary care providers (PCPs), typically working with nurse case managers. Nearly 60% of the sites reported dual PCPs involving VA and community‐based physicians. Nearly all sites provided access to a core set of comprehensive services and programs (e.g., case management, supportive home health care). At the same time, there were variations according to site (e.g., size, location (urban, rural), use of non‐VA hospitals, primary care models used).ConclusionHBPC sites reflected the rationale and mission of HBPC by focusing on complex chronic illness of home‐based veterans and providing comprehensive primary care using interdisciplinary teams. Our next series of studies will examine how HBPC site structural characteristics and care models are related to the processes and outcomes of care to determine whether there are best practice standards that define an optimal HBPC structure and care model or whether multiple approaches to HBPC better serve the needs of veterans.
Ethanol stimulates the in vivo axonal movement of neuropeptide dense‐core vesicles in Drosophila motor neurons
Authors: Iacobucci Gary J. , Gunawardena Shermali 
Published: September 2017

AbstractProper neuronal function requires essential biological cargoes to be packaged within membranous vesicles and transported, intracellularly, through the extensive outgrowth of axonal and dendritic fibers. The precise spatiotemporal movement of these cargoes is vital for neuronal survival and, thus, is highly regulated. In this study we test how the axonal movement of a neuropeptide‐containing dense‐core vesicle (DCV) responds to alcohol stressors. We found that ethanol induces a strong anterograde bias in vesicle movement. Low doses of ethanol stimulate the anterograde movement of neuropeptide‐DCV while high doses inhibit bi‐directional movement. This process required the presence of functional kinesin‐1 motors as reduction in kinesin prevented the ethanol‐induced stimulation of the anterograde movement of neuropeptide‐DCV. Furthermore, expression of inactive glycogen synthase kinase 3 (GSK‐3β) also prevented ethanol‐induced stimulation of neuropeptide‐DCV movement, similar to pharmacological inhibition of GSK‐3β with lithium. Conversely, inhibition of PI3K/AKT signaling with wortmannin led to a partial prevention of ethanol‐stimulated transport of neuropeptide‐DCV. Taken together, we conclude that GSK‐3β signaling mediates the stimulatory effects of ethanol. Therefore, our study provides new insight into the physiological response of the axonal movement of neuropeptide‐DCV to exogenous stressors.
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Cover Image for this Issue: doi: 10.1111/jnc.14165.
Radiological anatomy assessment of the fissura pterygomaxillaris for a surgical approach to ganglion pterygopalatinum
Authors: Puche‐Torres Miguel , Blasco‐Serra Arantxa , Campos‐Peláez Ana , Valverde‐Navarro Alfonso A. 
Published: September 2017

AbstractThe ganglion pterygopalatinum has become a therapeutic target to treat various pain syndromes in recent years. It is located in the fossa pterygopalatina, and the fissura pterygomaxillaris is the main access to surgically approach this structure. Recently, the neuromodulation of the ganglion pterygopalatinum by microstimulator implantation has become the first therapeutic line in refractory cluster headache treatment. This invasive technique is performed transorally through the fissura pterygomaxillaris, and is limited by the size of the implantation device, which requires an opening of at least 2 mm. Therefore, extensive knowledge about the anatomy of the fissura pterygomaxillaris prior to surgery is necessary to predict the success of both the approach and intervention. Likewise, establishing a morphological typology of the different fissura pterygomaxillaris variations would be a valuable predictive tool in the clinical practice. In this work, an anatomical analysis was performed of the morphological characteristics of the 242 fissurae pterygomaxillares, which corresponded to 121 adult patients, 58 males and 63 females, aged between 18 and 87 years. For each subject, right and left fissures were studied with radiological computed tomography images. Aperture fissura pterygomaxillaris measurements were taken in an upper (Measure A), middle (Measure B) and lower craneo‐caudal third (Measure C). Intra‐subject differences were studied between the measurements taken of each patient's right and left fissures, and the inter‐subject measures in which fissures were compared according to patients’ age and gender. The obtained results showed no significant differences between each patient's right and left fissures in any three measurements taken. Intra‐subject differences were not significant for gender or age. No statistically significant differences were found for the inter‐subject measures between the measures of fissures according to patients’ age. However, our data revealed that males’ fissurae pterygomaxillares were significantly larger than those of females in all three measures. Having analysed fissures, a typological classification was made according to the morphological patterns found. A 2‐mm limiting measure was considered, and Measures A, B and C of each fissure were classified depending on whether they had a value above or equal to 2 mm, or below 2 mm. With this classification criterion, four fissurae pterygomaxillares types were obtained. Type I and II fissure values (with a higher prevalence) were equal to or were greater than 2 mm in all three measures, or in two measures. Type III fissure values were only greater than or equal to 2 mm in Measure A, whereas all the Type IV fissure values were below 2 mm. Future studies are necessary to correlate the fissure types successfully proposed in the surgical ganglion pterygopalatinum approach.
Early recovery following lower limb arthroplasty: Qualitative interviews with patients undergoing elective hip and knee replacement surgery. Initial phase in the development of a patient‐reported outcome measure
Authors: Strickland Louise H , Kelly Laura , Hamilton Thomas W , Murray David W , Pandit Hemant G , Jenkinson Crispin 
Published: September 2017

Aims and objectivesTo explore the patients' perspective of surgery and early recovery when undergoing lower limb (hip or knee) arthroplasty.BackgroundLower limb arthroplasty is a commonly performed procedure for symptomatic arthritis, which has not responded to conservative medical treatment. Each patient's perspective of the surgical process and early recovery period impacts on their quality of life.DesignOpen, semistructured qualitative interviews were used to allow for a deeper understanding of the patient perspective when undergoing a hip or knee arthroplasty.MethodsFollowing ethical approval, 30 patients were interviewed between August and November 2016 during the perioperative period while undergoing an elective hip or knee arthroplasty (n = 30). The interviews were performed between the day of surgery and a nine‐week postoperative clinic appointment. Data were analysed using an in‐depth narrative thematic analysis method.NVivo qualitative data analysis software was used.ResultsSeven main themes evolved from the interviews: “improving function and mobility”, “pain”, “experiences of health care”, “support from others”, “involvement and understanding of care decisions”, “behaviour and coping” and “fatigue and sleeping”.ConclusionsThe early postoperative recovery period is of vital importance to all surgical patients. This is no different for the orthopaedic patient. However, identifying key self‐reported areas of importance from patients can guide clinical focus for healthcare professionals.Relevance to clinical practiceTo have specific patient‐reported information regarding key areas of importance during the perioperative phase is invaluable when caring for the orthopaedic surgical patient. It gives insight and understanding in to this increasing population group. This study has also served as a starting point in the development of a questionnaire which could be used to assess interventions in the lower limb arthroplasty population. These results will influence both items and content of the questionnaire.
Inadequate environment, resources and values lead to missed nursing care: A focused ethnographic study on the surgical ward using the Fundamentals of Care framework
Authors: Jangland Eva , Teodorsson Therese , Molander Karin , Muntlin Athlin Åsa 
Published: September 2017

Aims and objectivesTo explore the delivery of care from the perspective of patients with acute abdominal pain focusing on the contextual factors at system level using the Fundamentals of Care framework.BackgroundThe Fundamentals of Care framework describes several contextual and systemic factors that can impact the delivery of care. To deliver high‐quality, person‐centred care, it is important to understand how these factors affect patients' experiences and care needs.DesignA focused ethnographic approach.MethodA total of 20 observations were performed on two surgical wards at a Swedish university hospital. Data were collected using participant observation and informal interviews and analysed using deductive content analysis.ResultsThe findings, presented in four categories, reflect the value patients place on the caring relationship and a friendly atmosphere on the ward. Patients had concerns about the environment, particularly the high‐tempo culture on the ward and its impact on their integrity, rest and sleep, access to information and planning, and need for support in addressing their existential thoughts. The observers also noted that missed nursing care had serious consequences for patient safety.ConclusionPatients with acute abdominal pain were cared for in the high‐tempo culture of a surgical ward with limited resources, unclear leadership and challenges to patients' safety. The findings highlight the crucial importance of prioritising and valuing the patients' fundamental care needs for recovery.Relevance to Clinical PracticeNursing leaders and nurses need to take the lead to reconceptualise the value of fundamental care in the acute care setting. To improve clinical practice, the value of fundamentals of care must be addressed regardless of patient's clinical condition. Providing a caring relationship is paramount to ensure a positive impact on patient's well‐being and recovery.
Cross‐cultural development of hibiscus tea sensory lexicons for trained and untrained panelists
Authors: P. Monteiro Maria João , A. Costa Ana Isabel , Franco Maria Isabel , Bechoff Aurelie , Cisse Mady , Geneviève Fliedel , Tomlins Keith , E. Pintado Maria Manuela 
Published: September 2017

AbstractGiven the growing interest in high quality hibiscus teas and the scarcity of information about their sensory profile, lexicons were developed in French, Portuguese, and English. Twenty‐two samples, including freshly prepared and ready‐to‐drink (RTD) infusions, syrups, concentrates, and an instant tea were evaluated by trained panelists, resulting in 21 defined and referenced descriptors, subsequently assembled in a sensory wheel. The vocabulary used by untrained panelists was investigated in Senegal, Portugal, France, and United Kingdom through professional meetings (n = 30), consumer focus groups (n = 75) and check‐all‐that‐apply (CATA) studies (n = 490), resulting in graphical lexicons with 27 sensory and 15 overall impression terms. Training, food culture, and product familiarity influenced results. Trained panelists used precise terms to describe the aromatic profile of hibiscus teas (e.g., “reminiscent of dried hibiscus flowers,” with “berry,” “raisin,” “hay,” and “sweet” aromatic notes), whereas untrained ones were more prolific in general expressions (e.g., “strong in hibiscus” in Senegal; “floral” and “fruity” in Europe).Practical applicationsThis work provides a foundation for sensory research on hibiscus teas and practical support for product optimization processes, whether through hibiscus cultivar selection and breeding, improvement of harvest and postharvest operations or tea processing methods. Moreover, new lexicons will facilitate communication between the actors involved in the development, production, and marketing of hibiscus extracts and products thereof across Africa, Europe, and North/South America. Finally, potential drivers of hibiscus tea acceptance in both traditional and new markets are also identified.