bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Life Asset Management: Field T Value Optimization as the First Malaysian EOR Asset
Authors: Said Hani Mohd , Radzuan Fatin Raihanna , Zainol Amin Akmal , Mokhtar Affidah , Tajuddin Izzat Irfan Ahmad , Ghapor Zamri Abd 
Published: September 2024

Abstract
Enhanced Oil Recovery (EOR) via Water Alternating Gas (WAG) injection has given a new lease of life to Field T that has been producing for over 40 years. As the first large-scale, full-field offshore implementation of WAG EOR endeavor globally, this development that kicked off in 2014 has presented its fair share of challenges and successes. Since embarking on this journey, the field's capacity has grown by 300% in the span of eight years thanks to three key strategies in wells integrity management, maintaining EOR WAG efficiency and topside reliability maintenance.
For wells integrity management, prevention efforts are carried out via periodic downhole corrosion inhibitor injections of identified high-risk wells susceptible to corrosion and erosion. Caliper surveys and noise logs are also carried out to establish a baseline and identify any leaks which will be rectified either via non-rig wellwork intervention or rig workovers. In terms of dynamic reservoir management, detailed surveillance on the Gas-Oil Ratio and watercut is key to determining the optimum duration of water and gas injection cycles. Continuous gas lift optimization is also carried out as the amount of gas lift needed by each well changes between gas and water injection cycles. Lastly, maintaining topside reliability in key critical equipment such as WAG charge pumps, water injection pumps and gas compressor cooling pumps is crucial. This is necessary to maintain the ability to continuously inject gas and water to process the reservoir and sweep more oil. This was carried out via Single Point of Failure assessments and automation to optimize downtime.
By implementing these strategies, Field T currently boasts the highest percentage of active strings count in EMEPMI at 71% and improved topside uptime from 10% pre-EOR to less than 5% average post-EOR. The field capacity has also successfully grown by 300% in the span of eight years.
Figure 1 3 key strategies and focus areas in maximizing the value of EOR in Field T
MAD2-overexpressing interphase cell death (MOID)
Authors: Niikura Yohei , Xi Yao , Xu Rui , Chen Shengnan , Fang Jiezhu , Duan Xiang , Zhang Yidan , Zhong Guoli , He Zhifei , Guo Yan , Li Xinyu , Tao Wenzhi , Li Yang , Chen Lilan , Xu Haoming , Zhou Xinbo , Li Yan , Fang Lei 
Published: September 2024

Abstract

An in-depth comprehension of the molecular mechanisms behind the targeted eradication of cancer cells through cell death represents a requisite for effective anticancer treatments. However, the precise mechanism by which cell divisionrelated factors interact with intracellular organelles in the context of cancer cell death remains unclear. Mitotic arrest deficiency 2 (MAD2/MAD2L1), a pivotal component of the spindle assembly checkpoint (SAC), and its overexpression also resulted in many types of cancer. Here we show that the depletion of a microtubule-binding protein, tumor susceptibility gene 101 (TSG101), causes synthetic dosage lethality (SDL) in MAD2-overexpressing cells, and we term this cell death MAD2- overexpressing interphase cell death (MOID). MOID induction is p53-independent but AIFM1-dependent and caspase-activated cell death. The induction of MOID depends on PML and DAXX mediating mitochondrial AIFM1-release. C-terminal phosphorylations of TSG101 and closed (C-)MAD2-overexpression are required to induce MOID. Additionally, a part of MAD2 colocalizes with PML at PML nuclear bodies (PML NBs), and the PML release from PML NBs through PML deSUMOylation is required to induce MOID. The post-transcriptional/translational cell death machinery and the non-canonical transcriptional regulation of oxidative stress and ATM/ATR-mediated DNA double-strand breaks (DSB) - DNA damage response (DDR) are intricately linked to MOID. MOID is also associated with the activation of ROS and autophagy. PML localized at the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), i.e., ER-MAM, may serve as a crucial intersection for MOID signaling.
Comparison of efficacy and safety profiles of perioperative sufentanil and remifentanil: A systematic review and meta-analysis with trial sequential analysis
Authors: Kim Hyo Jin , Choi Geun Joo , Kang HYUN 
Published: September 2024

Abstract

Background:
Sufentanil and remifentanil are commonly used during general anesthesia. This systematic review and meta-analysis with trial sequential analysis of randomized controlled trials (RCTs) aims to comprehensively evaluate and compare the efficacy and safety profiles of perioperative sufentanil and remifentanil administration in patients undergoing surgery under general anesthesia.
Methods:
This study was registered in INPLASY (INPLASY202270070). A comprehensive search was performed using MEDLINE, EMBASE, CENTRAL, Web of Science, and Google Scholar to identify all RCTs comparing the efficacy of the intraoperative use of sufentanil to that of remifentanil. The primary outcome were the postoperative pain scores measured using visual analogue scale (VAS) or numerical rating scales (NRS). The secondary outcomes were the postoperative analgesic use, time to first analgesic need, intraoperative hemodynamic profiles, postoperative nausea and vomiting (PONV), incidence of respiratory depression, and recovery characteristics.
Results:
A total of 31 studies were included in the final analysis. Postoperative pain score was significantly higher in remifentanil group than that in sufentanil group (standardized mean difference [SMD] = -0.47; 95% confidence interval [CI] = 0.24 to 0.70). Postoperative analgesic amount used was lower in sufentanil group than that in remifentanil group. (SMD = 0.55; 95% CI = 0.12 to 0.99). In terms of hemodynamic profiles, intraoperative systolic blood pressure (weighed mean difference [WMD] = -6.30; 95% CI, = -10.76 to -1.85), mean arterial pressure (WMD = -6.38; 95% CI = -10.25 to -2.51), and heart rate (WMD = -4.16; 95% CI = -6.65 to -1.68) were lower in remifentanil group than in sufentanil group. Incidence of postoperative nausea (relative risk = 1.39; 95% CI = 1.13 to 1.71) was higher in remifentanil group than in sufentanil group. The remifentanil group showed a faster recovery profile than the sufentanil group.
Conclusions:
Compared with remifentanil, sufentanil demonstrated superior efficacy in postoperative pain management and superior safety profiles with respect to postoperative nausea and hemodynamic stability; however, remifentanil showed a faster recovery profile.
Systematic review registration
International Prospective Register of Systematic Reviews (INPLASY), NPLASY202270070)
Exploring evolutionary mechanisms of genomic divergence in Scurria limpets
Authors: Soto Paulina Carimán , Guillemin Marie-Laure , Giles Emily , Narváez Gabriela , Suescún Ana , Saenz-Agudelo Pablo 
Published: September 2024

Abstract

Decades of research in population genetics have revealed that genetic divergence between populations and species is not uniformly distributed throughout the genome, but rather exhibits a high degree of heterogeneity. This phenomenon has sparked debate regarding the evolutionary mechanisms responsible for this variability. This study delves into the patterns of genomic divergence in populations of three marine limpet species, Scurria scurra, Scurria araucana, and Scurria ceciliana, which inhabit both sides of two biogeographic breaks (30-34°S and 41-43°S). To investigate this, genomic divergence was analyzed using estimates of FST and DXY with a 20 kb sliding window approach across the entire genomes of 56 individuals. Highly divergent genomic regions ranging from 20 to 280 kilobases in size were identified, primarily associated with the allopatric divergence model in all three species, although significant signals of divergence with gene flow were observed in some regions. Sympatric populations of S. scurra and S. araucana, spanning the 30-34°S latitudinal range, exhibited heterogeneous divergence patterns. In S. ceciliana, the southernmost species with populations across the 41-43°S latitudinal range, the allopatric divergence and divergence with gene flow processes seem to have deeply affected the genomic architecture of divergence. This pattern was not expected for this species with an evolutionary history of populations being isolated in glacial refugia. Genetic divergence appears to be species-specific, with few shared regions, and genes relevant to lipid metabolism, response to oxidative stress, and mitochondrial functions were identified within regions of divergence. These findings highlight the complexity of genomic diversification in marine limpets.
Industrial policy and high-quality development of enterprise: The moderating role of business-government relations
Authors: Jiang Ying , Yin Guiku , Yang Zhongzhen 
Published: September 2024

Abstract

Industrial policy is a crucial instrument employed by the Chinese government to promote high-quality development of enterprises (HQDE). This study leverages the quasi-natural experiment formed by China's Chain Chief System (CCS) industrial policy, utilizing data from Chinese A-share listed companies during 2017–2022 and a difference-in-differences method to explore the relationships among industrial policy, HQDE, and business-government relations. Our findings indicate that the CCS policy can significantly promotes HQDE, with alleviating financing constraints and reducing agency costs identified as potential channels. Business-government relations play a pivotal role in moderating this positive relationship. Specifically, increases in state-owned equity proportions and geographical proximity between enterprises and government both enhance the promotional effect of CCS policy on HQDE. Furthermore, heterogeneity tests reveal that this promotional effect is more pronounced in state-owned enterprises, firms operating in high-tech industries, and those located in regions with less unfavorable business environments. These findings contribute to advancing debates on the effectiveness of industrial policies and deepens our understanding of the critical role of business-government relations.
Correlation Between Non-Stenotic Parent Artery Plaques and Lesion Imaging Features in Lenticulostriate Recent Small Subcortical Infarction: A High-Resolution Magnetic Resonance Imaging Study
Authors: Zhang Dandan , Zong Ce , Tao Yongli , Wu Zhengrong , Wang Sai , Gao Yuan , Xu Yuming 
Published: September 2024

Abstract

Previous studies have shown that lesions from recent small subcortical infarction (RSSI) with accompanying responsible vessel stenosis are closer to the openings of perforating branches and involve more slices on axial Magnetic Resonance Imaging (MRI). However, it remains unclear whether similar lesion characteristics are also associated with non-stenotic responsible vessel plaques that can be detected only by high-resolution MRI (HR-MRI). We enrolled consecutive patients with RSSI in the lenticulostriate artery (LSA) territory between January 2020 and December 2022. Patients with no visible stenosis in the ipsilateral middle cerebral artery (MCA) who completed HR-MRI were enrolled. Lesion characteristics including the lowest slice involved (LS), total number of slices involved (TNS) and maximal axial diameter (MAD) of RSSI lesions were evaluated by serialized axial levels of diffusion-weighted imaging (DWI). HR-MRI was used to assess the presence of dorsal superior plaques in the M1 segment of responsible MCA. Logistic regression analysis was performed to identify the lesion characteristics associated with the presence of dorsal superior plaques in the MCA. A receiver-operating characteristic (ROC) curve was employed to estimate the predictive efficacy of these parameters for MCA plaques using area under the ROC curve (AUC) and the optimal cut-off point. A total of 112 patients were included in the final analysis, with 57 (50.89%) having plaques detected on the dorsal superior wall of MCA. The average age of these patients was 57.08 years (57.08 ± 11.90 years), and 78 (69.64%) were male. Multivariate logistic regression showed that LS was significantly associated with MCA plaques (odds ratio [OR]: 0.674, 95% confidence interval [CI]: 0.485–0.937, p = 0.019). The optimal cut-off point (LS ≤ 1) was achieved by ROC curve analysis (AUC = 0.64, p = 0.007). The results indicate that in RSSI patients without responsible vascular stenosis, an LS ≤ 1 is significantly associated with the presence of dorsal superior plaques on the responsible vessel wall as detected by HR-MRI.
Evaluation of river discharges derived from remote sensing and land surface models
Authors: Duvvuri Bhavya , Gehring Jacyln , Beighley Edward 
Published: September 2024

Abstract

This study assesses river discharges derived using remote sensing and hydrologic modeling approaches throughout the CONUS. The remote sensing methods rely on total water storage anomalies (TWSA) from the GRACE satellite mission and water surface elevations from altimetry satellites (JASON-2/3, Sentinel-3). Surface and subsurface runoff from two Land Surface Models (NOAH, CLSM) are routed using the Hillslope River Routing model to determine discharge. The LSMs are part of NASA’s Global Land Data Assimilation System (GLDAS). Differences in key physical processes represented in each model, model forcings, and use of data assimilation provide an intriguing basis for comparison. Evaluation is performed using the Kling Gupta Efficiency and USGS stream gauges. Results highlight the effectiveness of both satellite-derived discharge methods, with altimetry generally performing well over a range of discharges and TWSA capturing mean flows. LSM-derived discharge performance varies based on hydroclimatic conditions and drainage areas, with NOAH generally outperforming CLSM. CLSM-derived discharges may be impacted by the use of data assimilation (GLDAS v2.2). Low correlation and high variability contribute to lower KGE values. GLDAS models tend to perform poorly in snow dominated, semi-arid and water-regulated systems where both the timing and magnitude of the simulated results are early and overestimated.
First step on the way to identify dermatophytes using odour fingerprints
Authors: Machová Lenka , Gaida Meriem , Semerád Jaroslav , Kolařík Miroslav , Švarcová Michaela , Jašica Andrej , Grasserová Alena , Awokunle-Hollá Sandra , Hubka Vít , Stefanuto Pierre-Hugues , Cajthaml Tomáš , Focant Jean-François , Čmoková Adéla 
Published: September 2024

Abstract

The clinical diagnosis of dermatophytosis and identification of dermatophytes face challenges due to reliance on culture-based methods. Rapid, cost-effective detection techniques for volatile organic compounds (VOCs) have been developed for other microorganisms, but their application to dermatophytes is limited. This study explores using VOCs as diagnostic markers for dermatophytes. We compared VOC profiles across different dermatophyte taxa using solid-phase microextraction (SPME) and advanced analytical methods: gas chromatography-mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC×GC-TOF MS). We analyzed 47 dermatophyte strains from 15 taxa grown on sheep wool, including clinically significant species. Additionally, we examined phylogenetic relationships among the strains to correlate genetic relatedness with metabolite production. Our results showed that GC×GC-TOF MS offered superior resolution but similar differentiation of VOC profiles compared to GC-MS. VOC spectra allowed reliable distinction of taxonomic units at the species level and below, although their relationships did not align with genetic phylogeny. We identified pan-dermatophyte and species- or strain-specific VOC profiles, indicating their potential for rapid, non-invasive detection of dermatophyte infections, including antifungal-resistant and epidemic strains. These patterns could enable future taxa-specific identification. Our study highlights the potential of VOCs as tools for dermatophyte taxonomy and diagnosis.
Exploring the use of observational tools for advancing patient safety learning among preregistration healthcare students: A scoping review using the 3P model of teaching and learning
Authors: Oli Radhika Upreti , Griffiths Leyshon , Norman Robert I , Anderson Elizabeth S 
Published: September 2024

Abstract

Background
Patient safety is a global health priority and a fundamental part of healthcare curricula worldwide. While teaching medical students on theoretical components is straightforward, students with little understanding of the pressures of front-line care, fail to prioritise patient safety. Using an observational tool for patient safety learning in real-clinical environments appears to help students engage with the significance of safe practice. This review seeks to identify learning approaches that use observational safety tools in practice.
Methods
This scoping review follows the JBI Evidence Synthesis Template. We searched Medline, CINAHL, Scopus, Web of Science, and The Cochrane Library for relevant papers published from 2009 to June 2024. Papers were appraised for quality indicators, and pedagogical theory and were synthesised using Bigg’s 3P theoretical model – presage (teaching setup), process (teaching), and product (evaluation and assessment).
Results
Of an initial 10,203 articles, only eight met the search criteria. The selected studies were conducted in North America (five) or Europe (three). The studies involved medical and nursing students in mid-to-late training and were for uni or interprofessional learning. Most studies involved a few representative students (range 11–368). They were conducted in acute clinical settings, including wards and theatres. All studies claimed the use of a safety tool advanced students’ learning and many involved monitoring real-time clinical practice. Students gained new knowledge, identified errors, valued learning in a student team and felt better prepared to speak up for errors. The studies failed to fully describe presage factors for set-up challenges and issues. They lacked rigour and adequate theoretical explanations about how learning took place (process). As the work was mainly descriptive and atheoretical, assessment outputs were lacking but evaluations were described.
Conclusions
Observational patient safety learning tools used in practice benefit students' understanding of patient safety, advancing their preparation for practice and remain under-studied and under-developed. The studies were often in their pilot development stages and hence involved few students. Further research on the use of patient safety education tools, used in practice, is urgently required to help educators with teaching design, delivery and assessment.
Trial Registration
Not applicable
Adipose-derived mesenchymal stem cell-conditioned medium accelerates wound healing in a rat model of full-thickness skin defects
Authors: Huang Long , He Huimin , Lin Zhongbao , Liu Haiyun , Lin Xiankun , Liao Naishun , Wu Xiaodan 
Published: September 2024

Abstract

Background: Considering that the therapeutic function of adipose tissue-derived mesenchymal stem cells (ADSCs) on skin wounds is closely related to their paracrine effect, this study was designed to investigate the therapeutic effect of ADSC conditioned medium (ACM) on type 2 diabetic (T2D) skin wound healing.
Methods: The effect of ACM on HUVEC viability and angiogenesis was firstly evaluated by CCK 8 assay and q-PCR analysis, respectively. Next, a T2D rat model was induced by the combination of high fat diet and streptozotocin. Following by the establishment of full-thickness skin defects in T2D rats, ACM or serum free cultured medium was daily injected around the wound edge sfor 7 days. Afterwards, the skin wound healing rate was analyzed, and the skin tissues were assessed by histopathological examination. The mRNA levels of TNF-α, IL-1β, IL-6, and COX-2, as well as IL-12 and IFN-γ were evaluated by q-PCR analysis. Additionally, the transcriptome sequencing and immunohistochemistry were used to reveal the potential mechanism of ACM for T2D skin wound healing.
Results: Our data showed that ACM promoted cell proliferation and angiogenesis, and up-regulated the mRNA expression of EGF, bFGF, VEGF, and KDR in HUVECs. The in vivo data indicated that ACM could accelerate T2D skin wound healing rate by inhibiting the mRNA levels of TNF-α, IL-1β, IL-6, and COX-2, as well as IL-12 and IFN-γ in vivo. Particularly, we also found that ACM could down-regulate TNF and chemokine signaling.
Conclusions: ACM could effectively promote vascular cell angiogenesis, accelerate skin wound regeneration by suppressing excessive inflammation in T2D rats, which is closely related to down-regulation of TNF and chemokine signaling pathways.
Improved lymph node detection in minimally invasive radical surgery for colorectal cancer using nanocarbon tracer
Authors: Xie Bingkai , Lin Guihe , Wang Zhijian , Xu Dongbo , Chen Jianxun , Lin Shuangming 
Published: September 2024

Abstract

To investigate the influencing factors of lymph node detection after minimally invasive radical surgery in patients with colorectal cancer (CRC) and the application value of carbon nanoparticle tracing. A total of 120 patients with CRC who underwent minimally invasive radical surgery were included. They were divided into groups according to whether they were grouped by carbon nano-tracers, and the baseline data were matched by propensity score method. Univariate and multivariate methods were used to evaluate lymph nodes and positive lymph nodes after minimally invasive radical surgery. The number of detected independent factors. After propensity score matching, there were 37 patients in the tracer group and the non-tracer group; there was no significant difference in baseline data between the two groups; the number of positive lymph nodes detected in the tracer group was significantly higher than that in the non-tracer group. The results of univariate analysis showed that gender, lesion location, maximum tumor diameter, and whether to perform nanocarbon tracing were all related to the number of lymph nodes detected after minimally invasive radical surgery. Nanocarbon tracing was an independent influencing factor for the number of lymph nodes detected after minimally invasive radical surgery. Pathological type, T stage, histopathological grade, nerve invasion, and whether or not with cancer nodules were all related to the number of positive lymph nodes detected after minimally invasive radical surgery; multivariate analysis showed that T stage, pathological Histological grade, vascular invasion, and cancer nodules were all independent influencing factors for the number of positive lymph nodes detected after minimally invasive radical surgery. The number of lymph nodes detected in patients with CRC after minimally invasive radical surgery is closely related to the location of the lesion and whether carbon nanoparticle tracing is performed; those with T2-4 stage, histological grade 3–4, combined with vascular invasion and cancer nodules are more likely to Positive lymph nodes were detected.