bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and activation of the innovative potential of the Russian economy: regional features, structural priorities, levels of implementation
Authors: Azjeurova K. E. , Kopteva Zh. Yu. , Shcherbakov D. B. 
Published: October 2024

Relevance. The idea of developing and implementing innovative solutions in various spheres of society implies the existence of ways to find such solutions, their active use and improvement. For this reason, the essence of innovative thinking on the scale of both a single enterprise and the state as a whole requires appropriate provision.The purpose of the research is a comprehensive analysis of the chronological cross-section of the level of innovative development of the subjects of the Russian Federation in the context of multiple global economic and political crises and the internal activation of strategic innovative trends in the formats of lawmaking and modernization.Objectives. To achieve this goal, within the framework of this study, the current legislative situation regarding the state's innovation policy and its projected consequences were considered; the factors of growth in the level of innovative development of the regions of the Russian Federation in the context of statistical dominants were studied; the complex results of regional innovation activity and the all-Russian state of the innovative sphere of development, production, export and import of goods and services were analyzed.Methodology. The methodological basis of this study is the method of chronological extrapolation analysis of trends with constant adjustment in conditions of the selective nature of the analytical data bank; in addition, a theoretical generalization of the indexed result and a priori trend forecasting within the observation period are used.Results. The general principles of the innovation segment development are the same for the whole state, but their applicability in different regions depends on the degree of their convergence with border territorial entities — the basis of the innovation development strategy is the assessment of regional potential in the sum of all indicators. Nevertheless, there is always the possibility of finding a thematic statistical trend.Conclusions. It is fundamentally important for the innovative development of the state to take into account the specifics of each individual region. With all the variety of means and methods of innovative development at all levels of management, priority is given to only a few. In this case, rating systems are an auxiliary element of management structures.
Prospects for the development of foreign economic activities of the Russia banking sector in China
Authors: Tretyakova I. N. , Korobkov I. A. 
Published: October 2024

Relevance. In modern conditions of economic uncertainty and difficulties of doing business in connection with the application of sanctions, banks need to look for effective tools and ways to increase the effectiveness of mutual cooperation with other states to overcome the prevailing circumstances. During the work, the main aspects of opening and functioning of a bank branch in China were considered, as well as competitors at both the macro and micro levels were analyzed. Based on the SWOT analysis, the paper identifies the strengths and weaknesses, opportunities and threats of introducing a branch of a Russian bank into the Chinese banking market. The study identifies promising regions for the development of foreign economic activity and forms a range of banking services that contribute to the sustainable development of the branch of the Russian bank in the foreign market.The purpose of the study is to substantiate the need to develop the foreign economic activity of a Russian commercial bank in China.Objectives: Based on a comprehensive analysis and acceptability of the Chinese banking services market, an assessment of the current state of PJSC Expobank, an analysis of competitors in the proposed region and the specifics of a specific location, to develop a plan for opening a bank branch in China.Methodology. The study is aimed at achieving this goal and is based on a review of scientific research by both domestic and foreign economists, as well as an analysis of a number of requirements for opening a bank branch in China.Results. In the course of the work, the process of opening a bank branch in China for carrying out activities was analyzed, the advantages and disadvantages of expanding the boundaries of presence were identified, and promising areas for starting foreign economic activity were proposed.Conclusions. The conducted research gives grounds to conclude that the expansion of the geographical presence in China will allow PJSC Expobank to gain access to world economic centers and expand the boundaries of its activities.
Social representations of young people about people with disabilities and disabilities in an inclusive educational environment: the experience of cross-cultural research
Authors: Nepochatykh E. P. 
Published: October 2024

Relevance. Interest in the study of social representations arose due to the development of inclusion in all spheres of life. This fact has an impact on the specifics of training Russian and foreign students in this field in a medical university, the development of their inclusive competence. The study of cross-cultural features of social representations of persons with disabilities and the disabled, the identification of universal and specific phenomena in respondents will contribute to understanding social and psychological phenomena at the individual level that determine social attitudes and behavior of individuals in an inclusive modern society, taking into account its sociocultural characteristics.The purpose of the study is to study the cross-cultural characteristics of social perceptions of people with disabilities and people with disabilities among Russian and foreign students.Objectives: to analyze the content characteristics and approaches to the study of social representations; to develop programs of empirical research; to describe the results of the study; to formulate conclusions.Methodology. This study is based on the provisions of the theory of social constructionism (P. Berger, T. Lukman; J.Douglas); E. Durkheim's concepts of collective representations; theories of social representations (S. Moscovici, D. Jodelet, etc.). Research methods: theoretical analysis of literature, research interview, method of verbal associations, testing, content analysis.Results. Both similar and specific phenomena in social representations of people with disabilities and people with disabilities in the samples of Russian and foreign students were revealed. Similar is the presence of tolerant attitudes towards people with disabilities and people with disabilities in both samples. The differences relate to the social level of social perceptions, as well as the characteristics of social distance in relation to respondents to this category of citizens.Conclusions. Along with a tolerant attitude towards people with disabilities and people with disabilities, respondents have insufficient professional awareness of this category of citizens, experience difficulties in interacting with them at the level of joint activities and professional relationships, which requires the development of additional programs and practices in the context of social, educational and volunteer activities to develop inclusive competence of students.
Creative self-realization of the individual in the educational environment of the university
Authors: Abramov A. P. , Shenyuk E. V. 
Published: October 2024

Relevance. In the modern world, youth are responsible for many areas of society, including the development of culture and the search for innovative ways of functioning of society. Creative activity is not only a form of self-expression and fulfillment of personal needs, but also becomes an important factor in the development of the economy and society as a whole. Stimulating creative activity is quite relevant in modern society, since creative activity itself is a key component of the development of innovation and progress in various fields.The purpose is theoretically substantiate and empirically determine the role of creativity in the process of personal self-realization in the educational environment of the university.Objectives: characterize theoretical approaches to the study of personal self-realization in creative activity; reveal the main tools and methods of stimulating the creative activity of the individual in the educational environment of the university; present traditional and innovative practices of creative self-realization of the individual.Methodology: the theoretical and methodological basis of the research is based on philosophical, sociological, psychological and pedagogical approaches that reveal the essence of creativity and its functional load.Results. The educational environment of the university is recognized as a significant factor that stimulates the process of acquiring new knowledge and increasing the level of creative self-realization of students. Most students are aware of the importance of creative self-realization in the process of studying at a university, but are not always satisfied with the level of its implementation.Conclusions. The comprehensive nature of the activities implemented at the university aimed at developing the creative potential of the individual ensures its effective self-realization. The creative environment created in classes and in extracurricular activities serves as a certain impetus for the development of students’ creative abilities, the transformation of their outlook on life, and helps in realizing and discovering personal potential for professional growth and self-development.
The role of state policy in shaping the culture of society: socio-philosophical ideas of the XVII ‒ XIX centuries
Authors: Malykhina R. V. 
Published: October 2024

Relevance. In modern society, conflicting opinions formed about the role of state shaping Russian culture. Changes concept cultural policy problem imbalance between the actions authorities and willingness citizens them. The search solution problem boils down study works sociologists and philosophers various historical periods, where question functions state and degree interference state policy cultural development society was raised.The purpose ‒ is to analyze scientific works XVII-XIX centuries, revealing the place and role state policy in shaping the culture of society.Objectives: to analyze the works R. Descartes, T. Hobbes, F. Bacon, A. Smith, F. Nietzsche, A. Saint-Simon, O. Konte, E. Durkheim; to formulate functions cultural policy; to present the role state in the cultural development society.Methodology. Research was conducted basis systematic approach within the framework structural functionalism using universal scientific methods such analysis, synthesis and generalization.Results. The main results are presented follows: within the framework this article, a study was conducted, with the help which we formulated peculiarities views sociologists and philosophers XVII-XIX centuries need state intervention in cultural processes society development, and highlighted functions cultural policy state.Conclusions. The socio-philosophical ideas XVII-XIX centuries evolved direction designating leading role state not only regulating cultural processes, but also educating younger generation through education and cultural development. The functions state century were largely reduced regulatory, and sometimes refusal participation government structures. Then, there was the recognition interaction society, culture state complementary elements, leading endowment state with such functions as: preservation traditions and protection from external influences, reflection interests society and education younger generation.
Assessment of the effectiveness of management at the regional level based on the analysis of the activities of authorities
Authors: Klevtsova M. G. , Aseeva O. Yu. , Chaplygina V. A. 
Published: October 2024

Relevance. The problem of effective management of regional development is becoming more and more urgent due to the emergence of new conditions (obstacles) of functioning, which pose the task of creating programs for the most effective management of subjects to the regions of Russia and executive authorities. It is important to note the choice of the subject: the Kursk region is an important region of the Central Federal District due to its potential and geographical location.The subject has a specialization in important sectors of the entire Russian economy, but at the same time may face inefficient management, which will cause a decline in the regional economy. The purpose is to assess the effectiveness of management of an economic entity on the example of the Kursk region by analyzing the activities of executive authorities.Objectives: to establish the parameters of effective management; to study regional policy as a means of increasing the effectiveness of regional development; to study methods for assessing the effectiveness of regional development through the prism of actions of public authorities; to compare the economic structures of the Kursk region and neighboring regions of the region using specific methodologies; to identify the main problems in the development of the Kursk region.Methodology. To carry out the research, methods of system analysis and synthesis, statistical data processing, as well as comparative and expert analysis are used. The results of the study include an analysis of the effectiveness of regional policy in the Kursk region and the identification of the main problems in the activities of government agencies that affect the economic growth of the subject.Conclusions. The Kursk Region is an ambiguous region regarding the quality of regional economic management. Studying the state support of subjects, their management by authorities, we can say that in the field of ecology and industrial development, the state supports the region sufficiently, since these areas are specialized in the region, which cannot be said about other areas. Despite the weak development of other industries, the state needs to provide significant support to such specialized sectors as agriculture and industry.
Management of integration projects within the framework of state support for partnership programs for small, medium and large businesses
Authors: Androsova I. V. 
Published: October 2024

Relevance. Small and medium-sized businesses have a significant impact on the development of the economy of any country. However, they often have difficulties in promoting their products (services) and strengthening their positions in the market. To solve this problem, it is necessary to activate integration projects of small and mediumsized enterprises with large companies in terms of providing access to public procurement.The purpose of writing this article is to develop measures and recommendations for small, medium and large businesses aimed at popularizing the development of joint partnerships, taking into account current government support.Objectives: Tasks: to assess the growth trends in the volume of purchases of companies with state participation from small and medium-sized enterprises; to consider the scheme of implementation of the partnership program for small and medium-sized enterprises and companies with state participation; to determine information and analytical support for business processes of interaction between major customers and SMEs in successfully implemented partnership programs; to develop recommendations for partner participants to popularize partnership programs.Methodology. When writing this article, a set of general scientific methods of cognition was used: observation, comparison, description, content analysis, as well as methods of program-targeted planning. Results. The article examines the practical aspects of the implementation of partnership programs for small, medium and large businesses; presents a register of participants in partnership programs in Russia by the end of 2023 from among SMEs (fragment); conducted a content analysis of the official websites of the largest customers (included in the TOP 5), successfully implementing partnership programs with small businesses in their activities and medium-sized businesses for information and analytical support of business processes of interaction.Conclusions. Measures and recommendations have been developed for all existing and potential participants in partnership programs (small, medium and large businesses). The creation of a single information space between the partners will make it possible to make appropriate management decisions regarding the implementation of possible integration projects.
Imaging Mutant Huntingtin Aggregates using [18F]CHDI-650 PET in a preclinical model of Huntington’s disease
Authors: Fairclough Michael , Jasim Dhifaf , Hall Tracy , Shoop Rosemary , Barjat Herve , Allen Tiffany , Shea Kerry , Marshall Gayle , Maynard Juliana , Liu Longbin , Sharp Paul 
Published: October 2024

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT) that encodes pathogenic mutant huntingtin (mHTT) protein. Therapeutic strategies aimed at lowering mHTT would benefit from non-invasive PET-based methods to evaluate treatment response. The CHDI foundation developed the first-generation PET ligands labelled with 11C, which advanced to clinical evaluation. Further optimization generated an 18F radioligand with improved metabolic stability, brain exposure and specificity, shown by PET imaging in wild-type mice and autoradiography in HD brain samples1,2. Here, we characterised the PET radioligand [18F]CHDI-650 in the R6/1 mouse model of HD to assess its sensitivity for monitoring treatment response of mHTT lowering therapies.
[18F]CHDI-650 was produced according to an established method3 using a TRACERlab system. Radiochemical purity/molar activity of the final [18F]CHDI-650 product was detected by reverse-phase HPLC analysis. Dynamic PET imaging was conducted using R6/1 mice and wild-type littermates at various disease stages. Image processing and kinetic modelling (2TCM) analysis were performed using PMOD software. Ex vivo brain radioactivity was measured using gamma counting. Brains were cryo-sectioned and processed for immunofluorescence to identify HTT load.
[18F]CHDI-650 was produced (1.3 ± 0.2 GBq) with an average radiochemical purity of 99.9 ± 0.1 % and a molar activity of 32.4 ± 5.2 GBq/µmol (n = 9). The radioligand was able to discriminate R6/1 HET from WT mice at an early presymptomatic age for both dynamic PET imaging (striatal) and ex vivo whole brain gamma. A well-defined age associated increase was also evident using both measures. Dual immunofluorescence spatially defined the level of aggregated HTT in striatal and hippocampal regions across the age groups.
[18F]CHDI-650 PET shows great potential as a non-invasive tool for visualising the development of mHTT pathology and as a biomarker for preclinical efficacy studies.
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The utility of PET-CT in baseline and sequential characterisation of Pulmonary Pleomorphic Carcinoma
Authors: Garrahy Darragh , Qian Teh Rui , Byrne Danielle , Beddy Peter 
Published: October 2024

Pulmonary Pleomorphic Carcinomas (PPCs) represent a rare and aggressive subtype of Non-Small Cell Lung Cancer (NSCLC) that can only be definitively diagnosed on a surgical specimen. This study utilised PET-CT to evaluate radiological characteristics of PPCs.
This study retrospectively evaluated the radiological characteristics of PCCs diagnosed in St James’s Hospital Dublin between 2012-2023. Computed Tomography (CT) and Positron Emission Tomography (FDG-PET) imaging features (size, location, density, shape, invasion, and growth kinetics) and standard uptake value for each lesion were evaluated.
39 PCCs were identified with a mean age of 66.5 years (range: 49-82 years). FDG-PET was performed in all 39 cases. Tumours demonstrated a high FDG uptake at baseline with a mean (SUV) of 12.6 (range: 1.4 - 36.9). A second interval PET-CT on average 3.3 months after the first in 3 cases demonstrated over 120% increase in SUV. The mean tumour size was 4.3 cm (range: 1.0 - 14.5 cm). Tumours developed rapid interval growth, reaching a mean maximum diameter of 6.6 cm (53.4%) within a mean of 2.1 months. Tumours were predominantly located in the upper lobe (71.8 %) and displayed necrotic features in 53.8 % of cases. 82.1% of tumours invaded the mediastinum.
This study describes the largest cohort of Pulmonary Pleomorphic Carcinoma in the literature. Tumours demonstrate a high SUV on baseline imaging and demonstrate rapid growth on interval imaging and central necrosis.
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Valvular and Myocardial Fibroblast Activation in Aortic Stenosis
Authors: Craig Neil , McDermott Michael , Geers Jolien , Loganath Krithika , Mahendran Menaka , Clark Laura , White Audrey , Whittington Beth , Barton Anna , Balmforth Craig , Lenell Joel , Williams Michelle , Van Beek Edwin , Dey Damini , Slomka Piotr , Newby David , Dweck Marc 
Published: October 2024

Activated fibroblasts drive leaflet thickening and left ventricular decompensation in aortic stenosis. Gallium-68 Fibroblast Activation Protein Inhibitor (68Ga-FAPI) binds to these key effector cells, and provides a readout of fibroblast activation. We aimed to describe the role of activated fibroblasts in patients with aortic stenosis in vivo using 68Ga-FAPI.
In a prospective observational study, patients with aortic stenosis and control subjects underwent echocardiography, 68Ga-FAPI PET, CT, and MRI. Valvular and myocardial 68Ga-FAPI uptake was quantified using maximal standardised uptake values (SUVmax), and target-to-background ratio (TBRmax). Aortic stenosis severity was measured by peak velocity on echocardiography and the CT calcium score. Myocardial fibrosis was quantified by late gadolinium enhancement (LGE) on MRI.
86 patients with aortic valve disease (72±11 years, 68% male) plus 9 matched control subjects (72±9 years, 67%% male) participated. Increased 68Ga-FAPI uptake was observed in the aortic valves of patients with aortic stenosis compared with controls (p<0.001). 68Ga-FAPI TBRmax correlated with peak velocity (r=0.532, p<0.0010) and calcium score (r = 0.577, p<0.001). 54 patients (69%) had myocardial 68Ga-FAPI uptake, of whom 30 (38%) also had LGE corresponding to the region of 68Ga-FAPI uptake. Myocardial 68Ga-FAPI uptake correlated with increased indexed left ventricular mass (r=0.429, p<0.001) and indexed Extracellular Volume (r=0.404, p<0.001).
For the first time, we have described valvular and myocardial fibroblast activation in patients with aortic stenosis in vivo. Valvular fibroblast activation is increased in patients with aortic stenosis, correlating with increased disease severity. Myocardial fibroblast activation is seen in the majority of patients with aortic stenosis in areas with and without established fibrosis, and is associated with adverse left ventricular remodelling. 68Ga-FAPI PET can visualise the key effector cell driving aortic valve disease, and may have a role in monitoring disease modifying treatments, as well as identifying patients at high risk of myocardial decompensation.
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