bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Multi‐Objective Optimization Model for Bridge Performance Assessment and Prediction, Based on Improved PCA, K‐Means Clustering, and Kaplan–Meier Survival Algorithm
Authors: Gui Chengzhong , Duan Zhi , Huang Zuwei , Sun Zhiguo , Qiao Wei , Cheng Yu 
Published: October 2024

ABSTRACTThe research proposes a hybrid algorithm model that combines model‐driven and data‐driven approaches for the direct application of bridge health monitoring technology in bridge management. This comprehensive study encompasses a series of analytical techniques and methodologies to build a multi‐objective optimization model for bridge performance assessment and prediction. It focuses on the processing of multi‐source heterogeneous data, selection of key sub‐parameters using Principal Component Analysis (PCA), enhanced K‐means clustering analysis, determination of structural component target thresholds, time‐dependent survival probability analysis, regression fitting, and timing prediction of the bridge system for both the components of double‐layer truss arch bridge and the bridge system. The initial phase of the study concentrates on the diversification and decentralization of monitored data from various sources, integrating and cleaning data obtained from different sources to ensure data quality and consistency. PCA technique is applied to identify key sub‐parameters that have significant impacts on the performance of structural components. Enhanced K‐means clustering analysis is carried out to effectively group and classify the identified key sub‐parameters. Numerical simulations, including structural nonlinear analysis, are conducted to determine the target thresholds of bridge structure, providing important benchmarks for performance evaluation. Finally, a multi‐parameter regression model is used to evaluate and update the performance of the bridge structure, taking into account survival probability (using the Kaplan–Meier method), maintenance history, and material deterioration to estimate the most critical time for the bridge system. A case study is conducted to validate the suggested comprehensive algorithms for a double‐layer truss arch combination bridge, which contributes to enhancing performance evaluation and predicting the most critical time for structural components and bridge system in the bridge management and maintenance practices. It should not be ignored that, the accuracy and reasonability of bridge structure system performance evaluation and prediction depend largely on the selection of target thresholds.
Encapsulation of Lacticaseibacillus rhamnosus by Extrusion Method to Access the Viability in Saffron Milk Dessert and Under Simulated Gastrointestinal Conditions
Authors: Ganje Mohammad , Sekhavatizadeh Seyed Saeed , Teymouri Fatemeh , Gilkheiri Mostafa , Rahmani Bentalhoda 
Published: October 2024

ABSTRACTThe effectiveness of probiotics in delivering health benefits may be associated with their capacity to maintain a minimum concentration of 106 CFU/g during food storage and to successfully colonize the gastrointestinal tract (GI). Lacticaseibacillus rhamnosus (LR) is a probiotic that does not exhibit adequate stability under harsh conditions. To enhance the survival capacity of LR during gastrointestinal storage, alginate (ALG) was used as a primary encapsulating layer through extrusion microencapsulation. Subsequently, camelina seed mucilage (CSM) and camelina seed protein (CSP) were applied as secondary layers at varying concentrations (0%–4%). Among the tested formulations, ALG‐CSM‐CSP (1.5%, 4%, 4% w/w) exhibited significantly higher encapsulation efficiency (94.15%) and provided appropriate LR encapsulation in SEM image. Three saffron milk desserts (SMD) containing free LR (FLR), microencapsulated LR (MLR), and a control (C) were prepared, followed by physicochemical and microbiological assessments of the samples. The result showed that at the end of storage, SMD had the lowest pH (6.21), the highest acidity (30°D), and maintained the permissible limit of probiotic bacteria (6.7 log cfu/mL) among the samples. In GI, the MLR and FLR survival rates were 43% and 45.4%, respectively on the 14th day of storage, respectively. The MLR hardness (313.70 g), adhesiveness (2.01 mJ), chewiness (9.36) and gumminess (58.8) had the greatest values among the samples. Moreover, SEM images showed a relatively denser structure for MLR. In conclusion, this study highlights the potential of CSM and CSP to protect probiotics, offering valuable insights for developing new functional foods with improved survival during storage and GI.
Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement
Authors: Kisioglu Betul , Onal Esra , Karabulut Derya , Onbasilar Ilyas , Akyol Asli 
Published: October 2024

ABSTRACTNeuroinflammation can be triggered by a high‐fat/high‐fructose diet (HFFD), and CD36 may be an underlying mechanism. Lauric acid (LA), the major fatty acid in coconut oil, and resveratrol, the plant‐based polyphenolic compound, may exert anti‐inflammatory effects. Therefore, this study investigated the possible effects of LA and resveratrol on diet‐induced neuroinflammation and CD36. Healthy male C57BL/6 mice (8 weeks of age, n = 31) were fed a control diet (10%kcal fat) or diets containing high fat (60%kcal fat) and fructose (5% w/v fructose drinking water) for 6 weeks, ad libitum. Supplemented to the HFFD, mice daily received resveratrol (7.5 mg/kg) (HFFD‐RSV) or LA (750 mg/kg) (HFFD‐LA). At the end of the study, HFFD resulted in anxiety‐like behavior, reduced locomotor activity, neuroinflammation (increased brain GFAP, IL‐6, MCP‐1, IFN‐γ, TNF‐α), and systemic inflammation (increased plasma GFAP, IFN‐γ, TNF‐α, IL‐12p70, reduced plasma IL‐10). HFFD‐RSV and HFFD‐LA alleviated HFFD‐induced anxiety‐like behavior, neuroinflammation, and systemic inflammation. HFFD‐LA improved memory. Brain and plasma CD36 levels were increased by HFFD and reduced by HFFD‐RSV or HFFD‐LA. Dietary resveratrol and LA intake may alleviate HFFD‐induced neuroinflammation, systemic inflammation, and anxiety‐like behavior and improve memory, as CD36 may be an underlying mechanism.
Influence of the Blends of Sheep's and Goat's Milk on the Functional Properties and Volatile Compounds of Lighvan Cheese During Ripening: A Comparative Study
Authors: Saremnezhad Solmaz , Soltani Mostafa , Tekin Ali , Kanmaz Hilal , Sahingil Didem , Kaya Büşra , Gökçe Yasemin , Hayaloglu Ali Adnan 
Published: October 2024

ABSTRACTIn this study, the influence of different ratios of sheep's to goat's milk (100:0, 75:25, 50:50, 25:75, and 0:100) on the content of functional metabolites and volatiles in Lighvan cheese throughout ripening was investigated. The samples were ripened under brine for 90 days and assessed in terms of variations in chemical composition, proteolysis, angiotensin‐converting enzyme, α‐amylase, and α‐glucosidase inhibitory activities, antioxidant power, total free amino acids, gamma amino butyric acid, free fatty acids, and volatile compounds. Results showed that by increasing the proportion of goat's milk, the samples exhibited higher antioxidant effect and inhibition of the angiotensin‐converting enzyme during ripening. After 90 days, an increase in α‐glucosidase and a slight decrease in α‐amylase inhibitory activities were observed in Lighvan cheese samples that were produced with 50%, 75% and 100% of goat's milk. In contrast, higher contents of sheep's milk led to a significant increase in the concentration of esters, terpenes and alcohols and a slight increase in gamma‐aminobutyric acid. The highest concentration of saturated and unsaturated fatty acids was observed in the cheese prepared with 100% raw sheep's milk after 90 days of ripening. The results revealed the possibility of making a functional white‐brined cheese by monitoring the type and ratio of the used milk and ripening time.
Long‐Term Outcomes of Dysphagia Rehabilitation With an Adjustable Resistance Training Device in Laryngectomized Individuals
Authors: Neijman Marise , Hilgers Frans J. M. , van den Brekel Michiel W. M. , van Son Rob J. J. H. , Stuiver Martijn M. , van der Molen Lisette 
Published: October 2024

ABSTRACTBackgroundThis study investigated long‐term outcomes of dysphagia rehabilitation with an adjustable resistance training device (Swallowing Exercise Aid, SEA2.0) in laryngectomized individuals.MethodsSeventeen laryngectomized participants who participated in a Clinical Phase II Trial were reevaluated at T3 (approximately 6 months after T2), including an interview, PROMS, oral intake, and swallowing capacity. Results of T3 were compared with the earlier time points T0 (baseline), T1 (after 6 weeks of training), and T2 (after 8 weeks of rest).ResultsAll outcomes at T3 remained improved compared to T0. Compared to findings at T2, participants reported some deterioration in swallowing at T3. Swallowing capacity and oral intake slightly decreased. Swallowing‐related quality of life slightly improved.ConclusionsBenefits of swallowing rehabilitation with the SEA2.0 in laryngectomized individuals are still noticeable long term. The need for continued exercising to fully maintain improved function is likely, but the required intensity and extent should be determined in further research.
Meta‐analysis of the comparison of laparoscopic pectopexy and laparoscopic sacrocolpopexy in the treatment of pelvic organ prolapse
Authors: Xiao Tingwei , Du Junxiao , Geng Jianfang , Li Lei 
Published: October 2024

AbstractBackgroundThe effectiveness and safety of laparoscopic pectopexy (LP) in the treatment of female pelvic organ prolapse (POP) have recently gained significant interest.ObjectiveThis study aimed to compare the outcomes and effectiveness of LP and laparoscopic sacrocolpopexy (LSC).Search StrategyA comprehensive literature search was conducted across multiple databases, including PubMed, MEDLINE, Embase, Web of Science, Cochrane Library, Clinical Trials, and CNKI. No language restrictions were applied in the search. The search encompassed the entire period from the inception of the respective databases to April 2023.Selection Criteria and Data CollectionAll randomized controlled trials and comparative studies were included. A cumulative analysis was conducted on 10 studies, accounting for 15% of the overall research pool. The sample sizes of these studies were 760. Two researchers independently evaluated the eligibility of the studies, collected the relevant data, and evaluated their potential bias.Main ResultsCompared with LSC, the average operation time for LP in the simple surgery group was shorter (standardized mean difference [SMD] –2.14, 95% CI –2.68 to −1.60, P < 0.001). The average bleeding volume was lower (SMD –3.17, 95% CI –5.22 to −1.12, P = 0.002), the postoperative indwelling catheterization time was shorter (SMD –0.35, 95% CI –0.67 to −0.02, P = 0.040), and there were fewer total postoperative complications (odds ratio [OR] 0.53, 95% CI 0.30–0.94, P = 0.030). In terms of effectiveness, the LP group had fewer postoperative prolapse recurrences than the LSC group (OR 0.33, 95% CI 0.14–0.77, P = 0.010).ConclusionLP demonstrates a comparable surgical efficacy to LSC. However, the surgical safety of LP is significantly improved. These findings should be validated by including additional randomized controlled trials.
Adenomyosis: A potential cause of surgical failure in treating dyspareunia in rectovaginal septum endometriosis
Authors: Mercorio Antonio , Della Corte Luigi , Dell'Aquila Michela , Pacella Daniela , Bifulco Giuseppe , Giampaolino Pierluigi 
Published: October 2024

AbstractObjectiveDyspareunia can severely impact the quality of life of patients with endometriosis. This symptom is often linked to a specific form of deep infiltrating endometriosis, such as rectovaginal septum endometriosis. Despite the radicality of surgery, persistence and recurrence of symptoms post‐surgery are not uncommon. The aim of the present study was to determine whether adenomyosis contributes to the failure of surgical interventions for dyspareunia in these patients.MethodsA retrospective single‐cohort study was conducted at the at tertiary care gynecologic center of the University Federico II of Naples, using medical records from January 2020 to July 2023. The study included patients who underwent surgery for dyspareunia associated with rectovaginal endometriosis and had a definitive histologic diagnosis. Pain and sexual quality of life were assessed using the visual analog scale (VAS) and the sexual quality of life‐female (SQoL‐F) questionnaire, both before and 6 months after surgery. Patients with isolated rectovaginal endometriosis were compared to those with concurrent adenomyosis.ResultsA total of 94 patients were included: thirty‐five in group A (endometriosis with adenomyosis) and 59 in group B (isolated rectovaginal endometriosis). Histology confirmed deep infiltrating endometriosis (DIE) in all patients. Clinical characteristics such as age, BMI, abnormal uterine bleeding, and infertility, showed no significant differences between the groups. Multiparity was more common in group A (20%) compared to group B (5.1%) (P < 0.001). Pain VAS scores decreased significantly in both groups: from 7.11 to 5.40 in group A and from 7.34 to 3.31 in group B (both P < 0.001). Sexual quality of life (SQoL) scores improved significantly: from 42 to 57 in group A and from 41 to 66 in group B (both P < 0.001). Patients in group B showed a more significant improvement. Adjusted linear regression showed no significant association between parity and the severity of dyspareunia or sexual quality of life.ConclusionAdenomyosis appears to reduce the effectiveness of surgical treatment for dyspareunia in patients with rectovaginal septum endometriosis. Comprehensive preoperative screening for adenomyosis is recommended to improve surgical outcomes and provide appropriate counseling. Future research should further explore the impact of adenomyosis on dyspareunia and the potential benefits of adjunctive medical therapies.
“I don't feel fully prepared”: a qualitative study of recently graduated students' mental health experiences of the transition out of university
Authors: Magier Megan J. , Law Madelyn , Martini Tanya , Pennisi Sarah , Lucibello Kristen M. , Patte Karen A. 
Published: October 2024

AbstractObjectiveThis study aimed to better understand the mental health experiences of students as they prepared to transition out of university.ParticipantsParticipants included 18 recently graduated students from a Canadian university.MethodsVirtual one‐on‐one semi‐structured qualitative interviews were conducted and analyzed following the protocol for content analysis and using QSR NVivo.ResultsFour main themes were identified, including: distress and feelings of doubt, the importance of connections, the impact of the COVID‐19 pandemic, and experiences with mental health service use. Participants discussed feeling pressured to succeed and a fear of failure, uncertainty and unpreparedness for next steps, the importance of connections to peers and professors, a lack of motivation and feeling ‘unfinished’ due to the COVID‐19 pandemic response, and the need for flexible and accessible mental health services to address immediate and longer‐term needs.ConclusionResults have implications for better support of students as they prepare for graduation.
Assessment of Optical Attenuation and Skin Thickness in Type 2 Diabetes Mellitus Patients Using Optical Coherence Tomography
Authors: Chen Minghui , Shen Yue , Zhu Jianguo , Su Tingwei , Zhang Yifei , Wang Weiqing , Chen Chang , Zhou Lin 
Published: October 2024

ABSTRACTDiabetes management often involves invasive blood glucose monitoring, which can be uncomfortable for patients. Non‐invasive techniques like multiple μ‐spatially offset Raman spectroscopy (mμSORS) offer a promising alternative. To provide clinical data supporting mμSORS, we conducted a clinical trial with 198 participants to evaluate mμSORS for non‐invasive blood glucose measurement. Using Optical Coherence Tomography, we studied skin thickness and optical attenuation in 172 diabetic and 26 healthy subjects. Results showed thicker stratum corneum and stratum spinosum (SS) in diabetics. Epidermal thickness increased with age and body mass index (BMI), decreased with skin brightness, and varied minimally with gender. Optical attenuation in SS was lower in diabetics, decreased with increasing a*, and was minimally affected by gender and BMI but increased with age in the upper dermis. These findings support mμSORS for accurate non‐invasive glucose monitoring.
CXCR4 up‐regulation mediated by USP1 deubiquitination promotes the tumorigenesis and immune escape in esophageal squamous‐cell carcinoma
Authors: Xiao Liang , Xu Haixia , Li Meixiang , Lin Lin , Zhu Yan 
Published: October 2024

AbstractCXC chemokine receptor 4 (CXCR4) and ubiquitin specific protease 1 (USP1) have been reported to involve in the tumorigenesis of esophageal squamous‐cell carcinoma (ESCC). Here, we investigated whether USP1 induced CXCR4 deubiquitination in regulating ESCC progression. MTT assay, 5‐ethynyl‐2'‐deoxyuridine assay, flow cytometry, transwell assay and ELISA analysis were used to detect cell oncogenic phenotypes, macrophage phenotypes, inflammatory cytokines production, the cytotoxicity of cytokine‐induced killer (CIK) cells and CD8 + T cell apoptosis. Protein interaction was determined by immunoprecipitation assay. Cellular ubiquitination detected the ubiquitination effect on CXCR4. A mouse xenograft model was established for in vivo experiments. CXCR4 was highly expressed in ESCC tissues and cells. Functionally, CXCR4 silencing suppressed ESCC cell proliferation, invasion, and induced cell apoptosis. Moreover, CXCR4 deficiency suppressed cancer cell immune escape by suppressing macrophage M2 polarization, elevating inflammatory cytokines produced by PBMCs, enhancing the cytotoxicity of CIK cells, and suppressing CD8 + T cell apoptosis. A high USP1 expression was observed in ESCC, USP1 interacted with CXCR4 and enhanced its protein stability through deubiquitination. USP1 silencing suppressed ESCC cell proliferation, invasion, and immune escape, which were reversed by CXCR4 overexpression. In vivo assay showed that USP1 deficiency impeded tumor growth by regulating CXCR4. Besides, fused in sarcoma (FUS) was confirmed to bind to USP1 and stabilized its mRNA expression, and could regulate CXCR4 via USP1. In conclusion, USP1 stabilized CXCR4 by removing ubiquitination on CXCR4, thereby promoting ESCC cell proliferation, invasion, and immune escape in vitro, and tumor growth in vivo.
Metabolic Compensation Associated With Digestion in Response to the Latitudinal Thermal Environment Across Populations of the Prairie Lizard (Sceloporus consobrinus)
Authors: Haussmann Benjamin D. , Hegdahl Tiffany R. , Robbins Travis R. 
Published: October 2024

ABSTRACTEnvironmental temperatures directly affect physiological rates in ectotherms by constraining the possible body temperatures they can achieve, with physiological processes slowing as temperatures decrease and accelerating as temperatures increase. As environmental constraints increase, as they do northward along the latitudinal thermal gradient, organisms must adapt to compensate for the slower physiological processes or decreased opportunity time. Evolving faster general metabolic rates is one adaptive response posited by the metabolic cold adaptation (MCA) hypothesis. Here we test the MCA hypothesis by examining metabolism of prairie lizard populations across the latitudinal thermal gradient. Our results show that populations from cooler environments have higher standard metabolic rates (SMRs), but these are explained by associated larger body sizes. However, metabolic rates of fed, postprandial individuals (MRFed) and metabolic energy allocated to digestion (MRΔ) were highest in the population from the coldest environment after accounting for the effect of body size. Our results suggest cold‐adapted populations compensate for lower temperatures and shorter activity periods by increasing metabolic rates associated with physiological processes and thus support the MCA hypothesis. When examining energy expenditure, metabolic rates of individuals in a postprandial state (MRFed) may be more ecologically relevant than those in a postabsorptive state (SMR) and give a better picture of energy use in ectotherm populations.
Nutrition support in children discharged from the pediatric intensive care unit: A bi‐national prospective cohort study (ePICUre)
Authors: Winderlich Jacinta , Little Bridget , Oberender Felix , Bollard Tessa , Farrell Tamara , Jenkins Samantha , Landorf Emma , McCall Andrea , Menzies Jessica , O'Brien Katie , Rowe Carla , Sim Kirsten , van der Wilk Melanie , Woodgate Jemma , Paul Eldho , Udy Andrew A. , Ridley Emma J. 
Published: October 2024

AbstractObjectivesThe role of nutrition in the recovery of critically ill children has not been investigated and current nutrition provision in the post‐pediatric intensive care unit (PICU) period is unknown. The primary objective of this study was to describe ward nutrition support in children following PICU discharge.MethodsChildren up to 18 years admitted to one of nine PICUs over a 2‐week period with a length of stay >48 h were enrolled. Data were collected on the first full ward day following PICU discharge and on Days 7, 14, 21, and 28 following PICU admission. Data points included oral intake, enteral (EN) and parenteral nutrition (PN) support, and oral and EN energy and protein provision.ResultsAmong the 108 children, on the first full ward day 75/108 (69%) children received EN, 54/108 (50%) oral intake, and 8/108 (7%) PN. Of those receiving oral nutrition only on the first full ward day (25/108; 23%), 9/25 (36%) received <50% of their estimated energy and protein requirements. Of those provided EN only, and where nutrition targets were known, on the first full ward day 8/46 (17%) and 7/46 (15%) met <75% of their estimated energy and protein requirements, respectively. On Day 28, this increased to 4/12 (33%) and 5/12 (42%).ConclusionsIn this study of ward‐based nutrition support, key findings included consistent use of EN and PN up to at least 28 days following PICU admission, and a high proportion of children receiving EN or oral intake only not meeting their estimated energy and protein requirements.