bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulasi Jaringan Drainase Kawasan Desa Lubuk Suli Kec. Depati VII Kabupaten Kerinci Menggunakan Program EPA SWMM Versi 5.1
Authors: Putri Ade Kurnia , Rahmawati Devit , Nasution Ari Endra 
Published: September 2024

One of the areas in Kerinci Regency that is often hit by floods is Lubuk Suli Village. Flooding was caused by overflowing water from the Batang Marao river. The main objective of this research is to provide information to the relevant government about good drainage for the Lubuk Suli Village Area using existing data and planning data by simulating the capability of the Drainage Network for the Lubuk Suli Village Area using the EPA SWMM 5.1 program. The data used in this research are land use maps to determine the percentage of impervious area, rainfall data and drainage channel dimension data in the area. The rain data series used is hourly rain data. Due to the absence of hourly rainfall data at the rain station at the research location, hourly rainfall distribution was determined by changing the Intensity-Duration-Frequency (IDF) curve for a 5 year return period into a planned rainfall hyetograph using the Alternating Block Method (ABM). After all parameters have been input into EPA SWMM 5.1. Simulation can be done. The simulation quality is quite good if the continuity error for surface runoff and flow tracing is > 10%. The simulation carried out in this research is divided into 2 scenarios, namely with existing data and additional storage. From the simulation results, it was found that in the 2 scenarios, the number of flood points in the simulation for scenario 1 was 6 points and in scenario 2 there were 5 points. This shows that the drainage planning design for the Lubuk Suli Village area has not been able to overcome the existing drainage load in the area.
Penilaian Agitasi Pada Pasien dengan Ventilasi Mekanis dan Tearpi Sedatif : A Case Report
Authors: Audly Tazkia Badliana , Emaliyawati Etika , Anna Anastasia 
Published: September 2024

Penilaian agitasi merupakan salah satu penilaian yang dilakukan untuk menilai status agitasi dan sedatif pada pasien perawatan khusus. Penggunaan ventilasi mekanis menyebabkan terjadinya agitasi pada pasien yang mempengaruhi manajamen sedatif pada pasien. Instrumen agitasi dapat menjadi acuan secara objektif, namun pengaplikasiannya masih jarang digunakan pada pasien perawatan khusus. Casse report ini bertujuan untuk menggambarkan risiko yang didapat pada Ny. L di ruang perawatan khusus tanpa penilaian agitasi secara objektif. Ny. L berusia 52 tahun yang di rawat di ruang Medical Intensive Care Unit (MICU) RSUP Dr. Hasan Sadikin Kota Bandung Provinsi Jawa Barat. Pasien mengalami gagal nafas dan terpasang ventilator dengan terapi sedatif dexmedetomidine. Pasien terpasang restrain pada kedua tangannya dan tampak gelisah. Penilaian agitasi secara objektif dan berkala tidak dilakukan oleh perawat. Hasil penelitian mendapatkan kegagalan dalam proses penyapihan pada Ny. L dengan ditandai adanya penurunan kondisi pasien hingga terjadi perubahan ventilator pada pasien yang memperpanjang Length Of Stay pasien di ruang intensive. Sehingga dapat disimpulkan risiko perburukan dapat terjadi pada pasien intensive Ketika pemantauan agitasi tidak akurat dan tidak valid diantaranya meningkatkan ketergantungan terapi sedatif dan ventilasi, Length Of Stay pasien lebih panjang, hingga proses penyapihan ventilator jangka panjang lebih dari 7 hari.
A Model of Creativity for Regional Culinary MSMEs: Developing Innovative Strategies
Authors: Yulianty Puspa Dewi , Aziz Muhammad Taufik 
Published: September 2024

In tight business competition and disruptive environmental conditions, the performance of Culinary MSMEs is the main support for economic growth. This research analyzes the influence of emotional intelligence and cognitive abilities on the creativity and business performance of Culinary MSMEs. This is quantitative research using the structural equation modeling method with Smart-PLS software. The data in this research is primary data obtained through distributing questionnaires to respondents consisting of 190 Muhammadiyah Culinary MSEs in the Cirebon. The results of the analysis show that intelligence and creativity of employees influence the business performance of Culinary MSMEs, while cognitive ability does not influence the performance of Culinary MSMEs. Furthermore, this research finds that emotional intelligence and cognitive ability influence the creativity of Culinary MSMEs.
The Role of A'bulosibatang Local Culture and its Relationship with Taxpayer Compliance in Gowa Regency
Authors: Muhaimin Muhaimin , Mira Mira , Akila Nur 
Published: September 2024

This research was conducted aims to determine the effect of a'bulosibatang on taxpayer compliance. Qualitative research type, which is a way used to answer research problems related to data in the form of narratives This research is a descriptive qualitative research using interviews as a research instrument. The informants are the people of Gowa who have become active taxpayers and are registered at the KP2KP Gowa Testing is done by triangulation (data coding, data reduction and conclusion drawing). The results showed that efforts to efforts to increase public trust in accountability and transparency government must continue to be encouraged. WPOP compliance in gowa Regency especially in limbung shows compliance in paying taxes, where cultural values such as cultural values such as Mutual Assistance, cooperation play a key role in the implementation of tax obligations. implementation of tax obligations. As for the implications of this research, it is in terms of formulating policies and regulations relating to existing taxation and increasing public confidence in the government's financial regulations especially for the tax funds collected. so that tax awareness and tax compliance becomes a joint responsibility as long as the government also contributes in terms of accountable and prosperous policies and management.
A digital patient-centered outcome tool for cervical dystonia
Authors: Pirio Richardson Sarah , Berman Brian D. , Hieshetter Janet , Comella Cynthia , Peterson David A. , Kilic-Berkmen Gamze , Wright Laura , Pentecost Samantha , Reyes Paul , Jankovic Joseph , Adler Charles H. , Tijssen Marina A. J. , Kimberley Teresa J. , Benson Monika , Perlmutter Joel S. , Qeadan Fares , Jinnah H. A. 
Published: September 2024

IntroductionTo establish clinical trial readiness for dystonia, a crucial step is to develop a Patient-Centered Outcome (PCO) measure to capture therapeutic response in focal dystonia such as in cervical dystonia (CD). Botulinum neurotoxin (BoNT) is the gold standard treatment for focal dystonia and yields improvement; yet the therapy may not meet all patient expectations as there is a high rate of discontinuation. A PCO that can measure therapeutic response, including the waxing and waning benefit of BoNT, across multiple domains and is easy to use on a frequent basis in the home environment is critical.MethodsA modified iterative Delphi process based on FDA (Food and Drug Administration) guidelines was used to develop and select items to document patient symptoms and response to treatment. Potential items then were improved using patient focus groups, validated for content with specialist panels, and confirmed items based on a patient survey. Using data from 200 CD patients in the Dystonia Coalition Natural History Database, initial PCO items were identified. Utilizing Random Forests, prospective items were analyzed for their contribution to the overall severity scores on the clinical and patient-centered outcome scales. Items that were repetitive were merged. Iterative meetings with a specialist panel consisting of neurologists, physical therapists, and Patient Advocacy Group (PAG) representatives as well as virtual focus groups of CD patients were held. An online survey was conducted with over 600 CD patients participating. Finally, specialist panel members provided input for a content validity ratio (CVR) with iterations until there was good agreement as to the relevance and clarity of the items.ResultsPCO measures tailored for CD were successfully developed. The PCO consists of 16 items covering three domains (motor, disability, and psychosocial) and reflects the input of international specialist panels, more than 800 CD patients, and PAGs (patient advocacy groups) following FDA guidance. The PCO is simple enough to be used in an app-based format compatible with smartphones and tablets.ConclusionThis comprehensive CD PCO measure was developed through the combination of using robust existing patient centered data (from previous Dystonia Coalition Projects); active engagement with PAGs to provide the patient voice; and use of virtual focus groups and online surveys. This PCO will be used in a prospective study to characterize the therapeutic response to BoNT over time. This will provide peak effect size as well as capturing the “yo-yo” effect during BoNT treatment; and will prepare for a future trials.
SERS-based microdroplet platform for high-throughput screening of Escherichia coli strains for the efficient biosynthesis of D-phenyllactic acid
Authors: Hu Lin , Luo Ruoshi , Wang Dan , Lin Fanzhen , Xiao Kaixing , Kang Yaqi 
Published: September 2024

D-Phenyllactic acid (D-PLA) is a potent antimicrobial typically synthesized through chemical methods. However, due to the complexity and large pollution of these reactions, a simpler and more eco-friendly approach was needed. In this study, a strain for D-PLA biosynthesis was constructed, but the efficiency was restricted by the activity of D-lactate dehydrogenase (DLDH). To address this issue, a DLDH mutant library was constructed and the Surface-Enhanced Raman Spectroscopy (SERS) was employed for the precise quantification of D-PLA at the single-cell level. The TB24 mutant exhibited a significant improvement in D-PLA productivity and a 23.03-fold increase in enzymatic activity, which was attributed to the enhanced hydrogen bonding and increased hydrophobicity within the substrate-binding pocket. By implementing multi-level optimization strategies, including the co-expression of glycerol dehydrogenase (GlyDH) with DLDH, chassis cell replacement, and RBS engineering, a significant increase in D-PLA yields was achieved, reaching 128.4 g/L. This study underscores the effectiveness of SERS-based microdroplet high-throughput screening (HTS) in identifying superior mutant enzymes and offers a strategy for large-scale D-PLA biotransformation.
Fabrication and growth mechanism of t-selenium nanorods during laser ablation and fragmentation in organic liquids
Authors: Baimler Ilya V. , Simakin Alexander V. , Dikovskaya Anastasia O. , Voronov Valery V. , Uvarov Oleg V. , Smirnov Alexander A. , Sibirev Alexey V. , Dorokhov Alexey S. , Gudkov Sergey V. 
Published: September 2024

IntroductionThe process of forming selenium nanoparticles with various shapes and structures through laser ablation and fragmentation in various solvents has been explored.MethodsLaser ablation and laser fragmentation techniques were employed using nanosecond Nd:YAG second harmonic laser irradiation in 9 different working fluids, including water. The characteristics of the resulting nanoparticles were assessed using transmission electron microscopy (TEM), dynamic light scattering (DLS), spectroscopy, and X-ray diffraction (XRD) methods.ResultsLaser ablation and subsequent laser fragmentation of some organic solvents, such as ethanol, propanol-2, isobutanol, polyethylene glycol, and diethanolamine, have been found to produce trigonal selenium in the form of elongated nanorods approximately 1 μm long and 200 nm thick, with a well-defined crystal structure. In contrast, the use of deionized water, acetone, glycerol, and benzene as solvents results in the formation of spherical amorphous nanoparticles approximately 100 nm in diameter.DiscussionThe polarity of the solvent molecules has been shown to influence the growth of crystalline selenium nanorods in solution during laser ablation and laser fragmentation. Generally, polar solvents hinder the growth of crystalline nanorods, due to interactions between selenium and solvent molecules. Nonpolar solvents, on the other hand, allow for laser fragmentation to reduce particle size and initiate the epitaxial growth of elongated, crystalline selenium nanorods.
Augmentation of communicative skills among rural high school students in India
Authors: Boobalan Rathika , Loganathan Saranraj , Gyamfi Abraham 
Published: September 2024

IntroductionThis study aims to focus on government school students, who struggle hard to express themselves in English.MethodsA two-group simple randomized design was used for this study, and an experimental study was carried out among 60 rural high school students. ‘Captivating activities’ (listening, speaking, reading, and writing) have been used to find the effect on learners’ communication skills. Furthermore, a pre-test and a post-test were conducted between groups, and their scores were analyzed. A paired sample t-test was carried out to identify the difference between controlled and experimental groups.ResultsThe results showed that there was a significant average difference observed between the pre-test and post-test scores (t28 = 8.327, p = 0.000, p &lt; 0.01) of the experimental group.DiscussionAs an outcome of the tested strategy, it was understood that an English-speaking environment can help students improve their language skills to some extent. It was concluded that the captivating activities (listening, speaking, reading, and writing) are effective for augmenting learners’ communication skills.
Cytosolic nucleic acid sensors and interferon beta-1 activation drive radiation-induced anti-tumour immune effects in human pancreatic cancer cells
Authors: Kerschbaum-Gruber Sylvia , Kleinwächter Ava , Popova Katerina , Kneringer Alexandra , Appel Lisa-Marie , Stasny Katharina , Röhrer Anna , Dias Ana Beatriz , Benedum Johannes , Walch Lena , Postl Andreas , Barna Sandra , Kratzer Bernhard , Pickl Winfried F. , Akalin Altuna , Horvat Filip , Franke Vedran , Widder Joachim , Georg Dietmar , Slade Dea 
Published: September 2024

IntroductionPancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths worldwide with limited treatment options due to extensive radiation and chemotherapy resistance. Monotherapy with immune checkpoint blockade showed no survival benefit. A combination of immunomodulation and radiotherapy may offer new treatment strategies, as demonstrated for non-small cell lung cancer. Radiation-induced anti-tumour immunity is mediated through cytosolic nucleic acid sensing pathways that drive the expression of interferon beta-1 (IFNB1) and proinflammatory cytokines.MethodsHuman PDAC cell lines (PANC-1, MIA PaCa-2, BxPC-3) were treated with X-rays and protons. Immunogenic cell death was measured based on HMGB1 release. Cytosolic dsDNA and dsRNA were analysed by immunofluorescence microscopy. Cell cycle progression, MHC-I and PD-L1 expression were determined by flow cytometry. Galectin-1 and IFNB1 were measured by ELISA. The expression levels and the phosphorylation status of the cGAS/STING and RIG-I/MAVS signalling pathways were analysed by western blotting, the expression of IFNB1 and proinflammatory cytokines was determined by RT-qPCR and genome-wide by RNA-seq. CRISPR-Cas9 knock-outs and inhibitors were used to elucidate the relevance of STING, MAVS and NF-κB for radiation-induced IFNB1 activation.ResultsWe demonstrate that a clinically relevant X-ray hypofractionation regimen (3x8 Gy) induces immunogenic cell death and activates IFNB1 and proinflammatory cytokines. Fractionated radiation induces G2/M arrest and accumulation of cytosolic DNA in PDAC cells, which partly originates from mitochondria. RNA-seq analysis shows a global upregulation of type I interferon response and NF-κB signalling in PDAC cells following 3x8 Gy. Radiation-induced immunogenic response is regulated by STING, MAVS and NF-κB. In addition to immunostimulation, radiation also induces immunosuppressive galectin-1. No significant changes in MHC-I or PD-L1 expression were observed. Moreover, PDAC cell lines show similar radiation-induced immune effects when exposed to single-dose protons or photons.ConclusionOur findings provide a rationale for combinatorial radiation-immunomodulatory treatment approaches in PDAC using conventional photon-based or proton beam radiotherapy.
Tumor-associated lymphatic vessel density is a reliable biomarker for prognosis of esophageal cancer after radical resection: a systemic review and meta-analysis
Authors: Li Jin , Wang Qing-Bo , Liang Yu-Bo , Chen Xing-Ming , Luo Wan-Ling , Li Yu-Kai , Chen Xiong , Lu Qi-Yu , Ke Yang 
Published: September 2024

PurposeTo explore whether tumor-associated lymphatic vessel density (LVD) could be a biomarker for the prognosis of patients with esophageal cancer after radical resection.MethodsA systematic literature search was performed through PubMed, EMBASE, Wanfang Data, and Cochrane Library from the inception of databases until March 19, 2024. The selected studies investigated overall survival (OS) and/or recurrence-free survival (RFS) of patients with esophageal cancer with different levels of LVD after radical resection. The OS and RFS data were pooled as hazard ratios (HR) and 95% confidential interval (CI). Furthermore, the standardized mean differences (SMDs) and 95% CI were aggregated to evaluate the correlation between LVD and clinicopathological features.ResultsA total of 10 retrospective studies of 1,201 patients were finally included for the meta-analysis. Patients with esophageal cancer with a high level of LVD exhibited worse OS (HR 1.65, 95% CI 1.18 to 2.31) and RFS (HR 1.57, 95% CI 1.09 to 2.26) than those with a low level of LVD. Subgroup analysis of different pathological subtypes revealed that patients with esophageal adenocarcinoma with a high level of LVD had significantly worse RFS (HR 2.84, 95% CI 1.61 to 5.02) than those with a low level of LVD; while patients with esophageal squamous cell carcinoma with a high level of LVD had similar OS (HR 1.52, 95% CI 0.93 to 2.47) and RFS (HR 1.03, 95% CI 0.72 to 1.48) to those with a low level of LVD. Furthermore, tumors with lymph node metastasis had significantly higher levels of LVD than those without lymph node metastasis (SMD = 1.11, 95% CI 0.54 to 1.67). Tumors at the stages III-IV had significantly higher levels of LVD than those at the stages I-II (SMD = 1.62, 95% CI 0.90 to 2.34).ConclusionA high level of LVD in tumor was associated with worse survival of patients with esophageal cancer after radical resection, especially in patients with esophageal adenocarcinoma. Tumor-associated LVD is a new parameter that should be measured in postoperative pathology for predicting the prognosis of patients with esophageal cancer.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/ PROSPERO, identifier CRD42024553766.
Comprehensive clinical phenotype, genotype and therapy in Yao syndrome
Authors: Nomani Hafsa , Wu Song , Saif Ashmia , Hwang Frank , Metzger Jane , Navetta-Modrov Brianne , Gorevic Peter D. , Aksentijevich Ivona , Yao Qingping 
Published: September 2024

ObjectiveYao syndrome (YAOS) is formerly called nucleotide-binding oligomerization domain containing 2 (NOD2)-associated autoinflammatory disease.We report a large cohort of YAOS.MethodsWe conducted a retrospective analysis of a cohort of adult patients with systemic autoinflammatory diseases (SAIDs). All patients underwent testing for a periodic fever syndrome gene panel.ResultsA total of 194 patients carried NOD2 variants, 152 patients were diagnosed with YAOS, and 42 had mixed autoinflammatory diseases with combined variants in NOD2 and other SAID-associated genes. Demographic, clinical and molecular data were summaried. In sub-group analysis of the 194 patients, individual patients were often identified to carry two or more variants that usually included IVS8 + 158/R702W, IVS8 + 158/L1007fs, IVS8 + 158/V955I, IVS8 + 158/other, or NOD2/variants in other SAID genes. Ninety-nine patients carried single variants. Taken together, these variants contribute to the disease in combination or individually.ConclusionThis largest cohort has provided comprehensive clinical and genotyping data in YAOS. Variants in the NOD2 gene can give rise to a spectrum from inflammatory bowel disease to autoinflammatory disease.This report further raises awareness of the underdiagnosed disease in the medical community.
Using interactive computer play in physical therapy and occupational therapy clinical practice: an explanatory sequential mixed methods study
Authors: Petrevska Marina , Ryan Jennifer L. , Sert Selvi , Munce Sarah , Wright F. Virginia , Biddiss Elaine 
Published: September 2024

IntroductionThis study explored the extent to which an interactive computer play system, Bootle Blast, supports motor learning in a clinical context and examined clinicians’ perceptions of their therapeutic role in the system’s use as an intervention tool.MethodsIn this observational sequential explanatory mixed methods study, five children with cerebral palsy [mean age 9.4 years (SD, 0.5), Gross Motor Function Classification System Levels I–III] used Bootle Blast during a single video-recorded therapy session with their treating clinicians (physical therapists, occupational therapists, and therapy assistants). Children played one Bootle Blast mini game independently (without clinician involvement) before clinicians carried out therapy sessions with the game as per usual care. The type and extent of motor learning strategies (MLS) delivered by Bootle Blast and clinicians were rated from video recordings by a trained assessor using the 22-item Motor Learning Strategies Rating Instrument. Semi-structured interviews with clinicians were conducted to gain insights into MLS use and clinicians’ perceived role during Bootle Blast use. Interviews were audio recorded, transcribed verbatim, and analyzed independently by two researchers using thematic analysis. Quantitative and qualitative data were merged and reported using narrative and joint display approaches.ResultsBootle Blast provided eight MLS, with clinicians adding or enhancing another eight. Four themes reflected clinicians’ perspectives: (1) Bootle Blast disguises therapy as play, (2) clinicians give Bootle Blast the human touch; (3) home use of Bootle Blast is promising; and (4) Bootle Blast is not always the right fit but some shortcomings could be addressed. Agreement was found for nine MLS and disagreement for four MLS when quantitative and qualitative findings were merged.DiscussionBootle Blast delivers several MLS as part of game play and clinicians can enhance and provide additional MLS to suit the child's needs/abilities. Further game refinements that were identified in this study may optimize its clinical use.