bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: AgN(CN)2/DIPEA/H2O‐EG: A Highly Efficient Catalytic System for Synthesis of 1,4‐Disubstituted‐1,2,3‐triazoles at Room Temperature.
Authors: Ali Abdul Aziz , Chetia Mitali , Saikia Bishwajit , Saikia Prakash J. , Sarma Diganta 
Published: March 2016

AbstractA simple and efficient method is developed for synthesizing 1,4‐disubstituted‐1,2,3‐triazoles using AgN(CN)2/DIPEA as catalyst in H2O/ethylene glycol at room temperature without the exclusion of air.
ChemInform Abstract: Oxidative Cyclization of N‐Aroylhydrazones to 2‐(2‐Arylethenyl)‐1,3,4‐oxadiazoles Using DDQ as an Efficient Oxidant.
Authors: Jasiak Karolina , Kudelko Agnieszka 
Published: March 2016

AbstractVarious novel title compounds are synthesized via the direct oxidative cyclization of α,β‐unsaturated acid hydrazides and aromatic aldehydes in a one‐pot procedure.
ChemInform Abstract: Synthesis of New Coumarin Containing Benzimidazole Derivatives.
Authors: Mentese Emre , Yilmaz Fatih , Mutlu Fatih , Kahveci Bahittin 
Published: March 2016

AbstractThe high yielding reaction between benzimidazole hydrazides and (benzotriazolylcarbonyl)chromenone is performed in a very small amount of solvent without a catalyst.
ChemInform Abstract: C(sp3)—H Functionalization of Methyl Azaarenes: A Calcium‐Catalyzed Facile Synthesis of (E)‐2‐Styryl Azaarenes and 2‐Aryl‐1,3‐bisazaarenes.
Authors: Yaragorla Srinivasarao , Singh Garima , Dada Ravikrishna 
Published: March 2016

AbstractA mild, efficient, and sustainable catalytic system for the C(sp3)—H functionalization of methyl azaarenes is reported.
ChemInform Abstract: 2‐Oxo‐Driven N2 Elimination Induced Decarbonylative Cyclization Reaction in Benzotriazoles to 6‐Aminophenanthridines.
Authors: Battula Satyanarayana , Kumar Atul , Gupta Ajai Prakash , Ahmed Qazi Naveed 
Published: March 2016

AbstractA variety of functional groups can be introduced in the phenanthridine skeleton following the 3‐component strategy shown.
ChemInform Abstract: A Facile One‐Pot Synthesis of Novel 1,2,4‐Triazolo[4,3‐a]pyridine Derivatives Containing the Trifluoromethyl Moiety Using Microwave Irradiation.
Authors: Yang Ming‐Yan , Zhai Zhi‐Wen , Sun Zhao‐Hui , Yu Shu‐Jing , Liu Xing‐Hai , Weng Jian‐Quan , Tan Cheng‐Xia , Zhao Wei‐Guang 
Published: March 2016

AbstractThe title compounds exhibit weak antifungal activity.
ChemInform Abstract: ZrOCl2·8H2O Catalyzed Solvent‐Free Friedlander Synthesis of 1,8‐Naphthyridines.
Authors: Mogilaiah K. , Rao A. Nageswara , Rao P. Koteswara 
Published: March 2016

AbstractThe title compounds are conveniently and rapidly obtained by solvent‐free grinding of aminonicotinaldehyde with various carbonyl compounds bearing an α‐methylene group.
ChemInform Abstract: A Facile and Efficient Synthesis of Hexahydro‐1H‐pyrido[2,3‐b]indol‐2‐one Scaffolds via a Sequential Michael Addition/Amidation/Reductive Cyclization Process.
Authors: Liu Xiong‐Li , Zhang Wen‐Hui , Yao Zhen , Liu Xiong‐Wei , Peng Li‐Jun , Zhao Zhi , Lu Yi , Zhou Ying , Yuan Wei‐Cheng 
Published: March 2016

AbstractA variety of products bearing a hexahydro‐1H‐pyrido[2,3‐b]indol‐2‐one core, a key structural skeleton in a large number of biologically active natural products and pharmaceutical compounds, are obtained with high efficiency.
ChemInform Abstract: Boron Tribromide‐Assisted Chiral Phosphoric Acid Catalyst for a Highly Enantioselective Diels—Alder Reaction of 1,2‐Dihydropyridines.
Authors: Hatano Manabu , Goto Yuta , Izumiseki Atsuto , Akakura Matsujiro , Ishihara Kazuaki 
Published: March 2016

AbstractFirst, catalysts (Ia) and (Ib) are established as the efficient ones for the cycloaddition of cyclic dienes (II) and (V) with acroleins (III) and acrylate (VII) under slightly different conditions.
ChemInform Abstract: A Quinine‐Squaramide Catalyzed Enantioselective Aza‐Friedel—Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron‐Rich Phenols.
Authors: Zhou Ding , Huang Zheng , Yu Xueting , Wang Youxin , Li Jian , Wang Wei , Xie Hexin 
Published: March 2016

AbstractThe procedure allows the access to biologically important chiral dihydroquinazolinones bearing a ‐CF3 function at the quaternary carbon.
ChemInform Abstract: A Cleavage Reaction of Benzothiazole with Cyclic 1,3‐Dicarbonyls in the Presence of Potassium Dihydrogen Phosphate.
Authors: Suliman Ayman Mohammed Yousif , Li Yanjun , Zhang Shaonan , Yuan Yu 
Published: March 2016

AbstractThe syntheses are carried out under mild and environmentally benign reaction conditions without use of any transition metal.
ChemInform Abstract: Copper‐Catalyzed Silylation of p‐Quinone Methides: New Entry to Dibenzylic Silanes.
Authors: Lopez Aurora , Parra Alejandro , Jarava‐Barrera Carlos , Tortosa Mariola 
Published: March 2016

AbstractThe title reaction can be used to synthesize non‐symmetric dibenzylic silanes in high yields under mild reaction conditions.
ChemInform Abstract: Novel Highly Oxygenated and B‐Ring‐seco‐ent‐Diterpene Glucosides from the Seeds of Prinsepia utilis.
Authors: Zhang Qiao , Liu Hong‐Xin , Tan Hai‐Bo , Qiu Sheng‐Xiang 
Published: March 2016

AbstractThree ent‐kaurane diterpene glucosides, prinsoside A (I), B (II) and C (III), respectively, are isolated from an ethanolic extract of the seeds of Prinsepia utilis.
ChemInform Abstract: Cytotoxic 24‐nor‐Ursane‐Type Triterpenoids from the Twigs of Mostuea hirsuta.
Authors: Longue Ekon Jean Pierre , Nouga Bissoue Achille , Formani Marie , Toze Flavien Aristide Alfred , Kamdem Alain Francois Waffo , Sewald Norbert , Wansi Jean Duplex 
Published: March 2016

AbstractTwo new 24‐nor‐ursane‐type triterpenoids (I) are isolated together with 15 known compounds.
ChemInform Abstract: Ligand and Copper Free Sonogashira Coupling to Achieve 2‐Alkynyl D‐Glucal Derivatives: Regioselective Electrophile Promoted Nucleophilic 5‐endo‐Dig Cyclization.
Authors: Shamim Anwar , Vasconcelos Stanley N. S. , Ali Bakhat , Madureira Lucas Sousa , Zukerman‐Schpector J. , Stefani Helio A. 
Published: March 2016

AbstractA very efficient Pd(OAc)2 catalyzed copper and ligand free Sonogashira coupling reaction is developed.
ChemInform Abstract: Surface Organometallic and Coordination Chemistry Toward Single‐Site Heterogeneous Catalysts: Strategies, Methods, Structures, and Activities
Authors: Coperet Christophe , Comas‐Vives Aleix , Conley Matthew P. , Estes Deven P. , Fedorov Alexey , Mougel Victor , Nagae Haruki , Nunez‐Zarur Francisco , Zhizhko Pavel A. 
Published: March 2016

AbstractReview: 696 refs.
ChemInform Abstract: Dehydrogenative Coupling Involving P(O)—H Bonds: A Powerful Way for the Preparation of Phosphoryl Compounds
Authors: Chen Tieqiao , Zhang Ji‐Shu , Han Li‐Biao 
Published: March 2016

AbstractReview: recent progress in the preparation of organo‐phosphorus compounds via transitin metal‐catalyzed dehydrogenative couplings of P(O)H compounds; 79 refs.
Shape of the Pulmonary Artery Doppler‐Flow Profile Predicts the Hemodynamics of Pulmonary Hypertension Caused by Left‐Sided Heart Disease
Authors: Kushwaha Shailendra P. , Zhao Qin‐Hua , Liu Qian‐Qian , Wu Wen‐Hui , Wang Lan , Yuan Ping , Zhang Rui , Jing Zhi‐Cheng 
Published: March 2016

ABSTRACTBackgroundPrevious studies demonstrated a relationship between pulmonary hemodynamics and shape of pulmonary artery (PA) Doppler‐flow profiles in a mixed pulmonary hypertension (PH) cohort.HypothesisShape of PA Doppler‐flow profiles could illustrate the hemodynamic characteristics of pulmonary venous hypertension (PVH), especially identifying it with or without pulmonary vascular disease (PVD).MethodsWe retrospectively analyzed hemodynamic, echocardiographic, and clinical data from 47 patients referred for PH caused by left‐sided heart disease (PH‐LHD). All patients underwent right‐sided heart catheterization within 1 week of echocardiography. We concluded a simple echocardiographic prediction rule to give hemodynamic differentiation of PVH with PVD, defined as capillary wedge pressure >15 mm Hg and pulmonary vascular resistance (PVR) >3 Wood units (WU). The PA Doppler‐flow profiles were categorized into 2 groups, no notch (NN) and MSN/LSN.ResultsThe PVR was higher in the MSN/LSN group at 4.04 WU (interquartile range, 3.1–5.3) vs the NN group at 1.91 WU (interquartile range, 1.8–3.0; P < 0.001). Pulmonary artery Doppler‐flow notching (MSN and LSN) was highly associated with PVR >3 WU, whereas the NN pattern predicted a PVR ≤3 WU (odds ratio: 19.8, 95% confidence interval: 4.3‐91.3) and normal transpulmonary pressure gradient ≤12 mm Hg (odds ratio: 4.7, 95% confidence interval: 1.3‐16.2). The NN pattern had 74% specificity and 88% sensitivity for PVR ≤3 WU.ConclusionsAbsence of PA Doppler‐flow notching was highly associated with PVH, and a notching pattern indicated PVH with PVD in the PH‐LHD cohort.
An association analysis and identification for unknown protocol of bitstream oriented
Authors: Zheng Jie 
Published: March 2016

SummaryAs for the bitstream data features in mobile wireless network, a method based on association rules was proposed to identify the unknown protocol in certain circumstances. The method improved traditional protocol identification technology to reduce its limitation by ways of port number and fixed features of known protocol. Through capturing bitstream data transmitted in wireless environment, the method extracted the feature information and also mined the association rules to identify and mark the unknown protocol using the learning mechanism of machine. Then the unknown protocol in a specific environment was found and analyzed by marking the fingerprint information of protocol. Finally, the efficiency of the method was evaluated by two kinds of protocol to obtain that the average recognition rate of protocol was more than 99%, while the average false‐recognition rate is less than 0.6%. Copyright © 2016 John Wiley & Sons, Ltd.
Solution‐State One‐ and Two‐Dimensional NMR Spectroscopy of High‐Molecular‐Weight Cellulose
Authors: Holding Ashley J. , Mäkelä Valtteri , Tolonen Lasse , Sixta Herbert , Kilpeläinen Ilkka , King Alistair W. T. 
Published: March 2016

AbstractHigh‐molecular‐weight celluloses (which even include bacterial cellulose) can be dissolved fully in methyltrioctylphosphonium acetate/[D6]DMSO solutions to allow the measurement of resonance‐overlap‐free 1 D and 2 D NMR spectra. This is achieved by a simple and non‐destructive dissolution method, without solvent suppression, pre‐treatment or deuteration of the ionic component. We studied a range of cellulose samples by using various NMR experiments to make an a priori assignment of the cellulose resonances. Chain‐end resonances are also visible in the 1H NMR spectrum. This allows the rough determination of the degree of polymerisation (DP) of a sample for low‐DP celluloses by the integration of non‐reducing chain ends C1 versus polymeric cellobiose C1. Low‐DP celluloses show a good agreement with the gel‐permeation chromatography (GPC) values, but high‐DP pulps show more deviation. For high‐purity pulps (pre‐hydrolysis kraft and sulfite), residual xyloses and mannoses can also be identified from the 1H–13C heteronuclear single‐quantum coherence (HSQC) spectra. Resonances are thus assigned for the common polymeric polysaccharides found in chemical pulps.
Design Criteria, Operating Conditions, and Nickel–Iron Hydroxide Catalyst Materials for Selective Seawater Electrolysis
Authors: Dionigi Fabio , Reier Tobias , Pawolek Zarina , Gliech Manuel , Strasser Peter 
Published: March 2016

AbstractSeawater is an abundant water resource on our planet and its direct electrolysis has the advantage that it would not compete with activities demanding fresh water. Oxygen selectivity is challenging when performing seawater electrolysis owing to competing chloride oxidation reactions. In this work we propose a design criterion based on thermodynamic and kinetic considerations that identifies alkaline conditions as preferable to obtain high selectivity for the oxygen evolution reaction. The criterion states that catalysts sustaining the desired operating current with an overpotential <480 mV in alkaline pH possess the best chance to achieve 100 % oxygen/hydrogen selectivity. NiFe layered double hydroxide is shown to satisfy this criterion at pH 13 in seawater‐mimicking electrolyte. The catalyst was synthesized by a solvothermal method and the activity, surface redox chemistry, and stability were tested electrochemically in alkaline and near‐neutral conditions (borate buffer at pH 9.2) and under both fresh seawater conditions. The Tafel slope at low current densities is not influenced by pH or presence of chloride. On the other hand, the addition of chloride ions has an influence in the temporal evolution of the nickel reduction peak and on both the activity and stability at high current densities at pH 9.2. Faradaic efficiency close to 100 % under the operating conditions predicted by our design criteria was proven using in situ electrochemical mass spectrometry.
The Importance of End Groups for Solution‐Processed Small‐Molecule Bulk‐Heterojunction Photovoltaic Cells
Authors: Duan Ruomeng , Cui Yong , Zhao Yanfei , Li Chen , Chen Long , Hou Jianhui , Wagner Manfred , Baumgarten Martin , He Chang , Müllen Klaus 
Published: March 2016

AbstractEnd groups in small‐molecule photovoltaic materials are important owing to their strong influence on molecular stability, solubility, energy levels, and aggregation behaviors. In this work, a series of donor–acceptor pentads (D2–A–D1–A–D2) were designed and synthesized, aiming to investigate the effect of the end groups on the materials properties and photovoltaic device performance. These molecules share identical central A–D1–A triads (with benzodithiophene as D1 and 6‐carbonyl‐thieno[3,4‐b]thiophene as A), but with various D2 end groups composed of alkyl‐substituted thiophene (T), thieno[3,2‐b]thiophene (TT), and 2,2′‐bithiophene (BT). The results indicate a relationship between conjugated segment/alkyl chain length of the end groups and the photovoltaic performance, which contributes to the evolving molecular design principles for high efficiency organic solar cells.
Stereoselective Cyclopropanation as a Way to 1‐Aminocyclopropane‐1‐phosphonic Acids: Rationale for Phosphoryl Group Migration
Authors: Midura Wanda H. , Cypryk Marek , Rzewnicka Aneta , Krysiak Jerzy A. , Sieroń Lesław 
Published: March 2016

AbstractAsymmetric cyclopropanation of vinylphosphonates by using (S)‐dimethylsulfonium(p‐tolylsulfinyl)methylide and subsequent highly stereoselective methylation provided substituted cyclopropylphosphonates, which are useful intermediates in the synthesis of rigid aminophosphonic acids. However, in some examples desulfinylation by iPrMgCl led to 1,2‐migration of the phosphoryl group. The scope of this transformation was investigated by changing the temperature, electronegativity of the substituent α to phosphoryl group, and the configuration of the cyclopropylphosphonates. It was found that a cis relationship between the phosphoryl and sulfinyl groups led exclusively to the product of migration. It was proposed that the rearrangement occurred as an internal process in a concerted manner. The feasibility of an intramolecular mechanism was supported by DFT calculations. The products of desulfinylation with retained structure were used for the synthesis of enantiomerically pure 1‐aminocyclopropane‐1‐phosphonic acids.
Hippocampal sub‐regional shape and physical activity in older adults
Authors: Varma Vijay R. , Tang Xiaoying , Carlson Michelle C. 
Published: March 2016

ABSTRACTHippocampal atrophy is a hallmark of Alzheimer's disease pathology, and a target biomarker region for testing intervention efficacy. Over the last few decades, a growing body of evidence from animal and human models suggests that physical activity (PA) is associated with structural benefits to the hippocampus in older adults. Very few human studies, however have explored hippocampal sub‐regional specificity of PA; this is significant considering that sub‐regions of the hippocampus are associated with distinct cognitive tasks and are differentially affected by disease pathology. This study used objective and self‐reported measures of daily walking activity and exercise, and surface‐based regional shape analysis using high‐field hippocampal sub‐regional partitions to explore sub‐region specific hippocampal associations in a sample of nondemented, community‐dwelling older adults at elevated sociodemographic risk for cognitive decline. Vertex‐wise surface areas, which may be more sensitive than global volume measures, were calculated using shape diffeomorphometry, and PA was assessed using step activity monitors and PA questionnaires. We found that daily walking activity in a participant's environment was associated in cross‐section mainly with larger surface areas of the subiculum in women. Associations remained significant when controlling for self‐reported exercise. Prior studies have found that PA related to exercise and aerobic fitness may be most closely associated with the anterior hippocampus, particularly the dentate gyrus of the hippocampus. These novel findings are the first, to our knowledge, in human models to suggest that PA related to navigation that may not reach the level of moderate‐intensity exercise may be associated with specific sub‐regions of the hippocampus. These findings underscore the importance of better understanding the independent and related biological mechanisms and pathways by which increasing exercise as well as non‐exercise, lifestyle PA may influence structural brain health. © 2016 Wiley Periodicals, Inc.
Functional cross‐hemispheric shift between object‐place paired associate memory and spatial memory in the human hippocampus
Authors: Lee Choong‐Hee , Ryu Jungwon , Lee Sang‐Hun , Kim Hakjin , Lee Inah 
Published: March 2016

ABSTRACTThe hippocampus plays critical roles in both object‐based event memory and spatial navigation, but it is largely unknown whether the left and right hippocampi play functionally equivalent roles in these cognitive domains. To examine the hemispheric symmetry of human hippocampal functions, we used an fMRI scanner to measure BOLD activity while subjects performed tasks requiring both object‐based event memory and spatial navigation in a virtual environment. Specifically, the subjects were required to form object‐place paired associate memory after visiting four buildings containing discrete objects in a virtual plus maze. The four buildings were visually identical, and the subjects used distal visual cues (i.e., scenes) to differentiate the buildings. During testing, the subjects were required to identify one of the buildings when cued with a previously associated object, and when shifted to a random place, the subject was expected to navigate to the previously chosen building. We observed that the BOLD activity foci changed from the left hippocampus to the right hippocampus as task demand changed from identifying a previously seen object (object‐cueing period) to searching for its paired‐associate place (object‐cued place recognition period). Furthermore, the efficient retrieval of object‐place paired associate memory (object‐cued place recognition period) was correlated with the BOLD response of the left hippocampus, whereas the efficient retrieval of relatively pure spatial memory (spatial memory period) was correlated with the right hippocampal BOLD response. These findings suggest that the left and right hippocampi in humans might process qualitatively different information for remembering episodic events in space. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.
Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment
Authors: Kajimoto Kenta , Valenzuela C. Fernando , Allan Andrea M. , Ge Shaoyu , Gu Yan , Cunningham Lee Anna 
Published: March 2016

ABSTRACTPrenatal alcohol exposure (PAE) results in fetal alcohol spectrum disorder (FASD), which is characterized by a wide range of cognitive and behavioral deficits that may be linked to impaired hippocampal function and adult neurogenesis. Preclinical studies in mouse models of FASD indicate that PAE markedly attenuates enrichment‐mediated increases in the number of adult‐generated hippocampal dentate granule cells (aDGCs), but whether synaptic activity is also affected has not been studied. Here, we utilized retroviral birth‐dating coupled with whole cell patch electrophysiological recordings to assess the effects of PAE on enrichment‐mediated changes in excitatory and inhibitory synaptic activity as a function of DGC age. We found that exposure to an enriched environment (EE) had no effect on baseline synaptic activity of 4‐ or 8‐week‐old aDGCs from control mice, but significantly enhanced the excitatory/inhibitory ratio of synaptic activity in 8‐week‐old aDGCs from PAE mice. In contrast, exposure to EE significantly enhanced the excitatory/inhibitory ratio of synaptic activity in older pre‐existing DGCs situated in the outer dentate granule cell layer (i.e., those generated during embryonic development; dDGCs) in control mice, an effect that was blunted in PAE mice. These findings indicate distinct electrophysiological responses of hippocampal DGCs to behavioral challenge based on cellular ontogenetic age, and suggest that PAE disrupts EE‐mediated changes in overall hippocampal network activity. These findings may have implications for future therapeutic targeting of hippocampal dentate circuitry in clinical FASD. © 2016 Wiley Periodicals, Inc.
A single bout of resistance exercise improves memory consolidation and increases the expression of synaptic proteins in the hippocampus
Authors: Fernandes Jansen , Soares Juliana Carlota Kramer , do Amaral Baliego Luiz Guilherme Zaccaro , Arida Ricardo Mario 
Published: March 2016

ABSTRACTOver the past decade, several studies have indicated that chronic resistance exercise (i.e., strength training, weight lifting, etc.) is beneficial for brain health and cognitive function. However, little is known about the effects of a single bout of resistance exercise on brain function, particularly on memory consolidation. Therefore, the purpose of the present study is to examine the effects of a single bout of resistance exercise applied immediately after the training of fear conditioning on memory consolidation and on the expression of IGF‐1 and synaptic proteins in the hippocampus. Male Wistar rats were familiarized with climbing a ladder without a load for 3 days and randomly assigned into control (CTL) and resistance exercise (RES) groups. The RES group was subjected to a single bout of resistance exercise applied immediately after fear conditioning training. Subsequently, the animals were tested for contextual (24 h) and tone (48 h) fear memory. Another group of animals were subjected to a single bout of resistance exercise and euthanized 24 h later for hippocampal analysis of IGF‐1 and synaptic proteins (synapsin I, synaptophysin, and PSD‐95). The exercised rats improved contextual but not tone fear memory. Hippocampal IGF‐1 was not altered by resistance exercise. However, the levels of synapsin I, synaptophysin, and PSD‐95 increased significantly in the RES group. The results suggested that a single bout of resistance exercise applied immediately after fear conditioning could improve contextual memory, probably through the activation of pre‐ and postsynaptic machinery required for memory consolidation. © 2016 Wiley Periodicals, Inc.