bluuebunny/crossref_metadata_2025_split huggingface dataset:
The NCX1 calcium exchanger is implicated in delayed axotomy after peripheral nerve stretch injury
Authors: Wilhelmy Bradley , Gerzanich Volodymyr , Simard J. Marc , Stokum Jesse A. 
Published: October 2024

AbstractBackground and AimsAfter peripheral nerve stretch injury, most degenerating axons are thought to become disconnected at the time of injury, referred to as primary axotomy. The possibility of secondary axotomy—a delayed and potentially reversible form of disconnection—has not been evaluated. Here, we investigated secondary axotomy in a rat model of sciatic nerve stretch injury. We also evaluated whether axon sparing and functional improvement results from pharmacological blockade of the sodium‐calcium exchanger 1 (NCX1), which is widely believed to contribute to traumatic axon degeneration but was previously only investigated in vitro.MethodsWe studied peripheral nerve secondary axotomy in a clinically relevant rat model of sciatic nerve rapid stretch injury with immunolabeling and fluorescence microscopy. The role of NCX1 in secondary axotomy was studied with pharmacological inhibition with SEA0400 and immunolabeling, immunoblot, and behavioral assays.ResultsWe found that early after injury, many axons remained in‐continuity and that degeneration of axons was delayed, consistent with the occurrence of secondary axotomy. βAPP, a marker of secondary axotomy, accumulated at regions of axon swelling and disconnection, and NCX1 was upregulated and co‐localized to βAPP axonal swellings. Pharmacological blockade of NCX1 after injury reduced calpain activation, proteolytic degradation of neurofilaments, βAPP accumulation, distal axon degeneration, and improved hindlimb function.InterpretationOur data demonstrate a major role for secondary axotomy in peripheral nerve stretch injury and identify NCX1 as a promising therapeutic target to reduce secondary axotomy and improve functional outcome after nerve injury.
The New Frontier of JAK Inhibitors: Significant Therapeutic Response to Tofacitinib in a Patient With Granulomatous Reaction to Filler in the Buttocks
Authors: Mansouri Parvin , Farshi Susan 
Published: October 2024

ABSTRACTBackgroundRecent research has demonstrated that Janus Kinase (JAK) inhibitors can be effective in treating refractory granulomatous diseases.Case PresentationWe report the case of a 50‐year‐old woman who developed a granulomatous reaction following a filler injection in her buttocks.ManagementThe patient was treated with tofacitinib, and after 1 year of therapy, the stiffness and swelling resolved without any side effects.ConclusionTofacitinib appears to be a viable option for the treatment of granulomatous reactions to fillers.
Early pregnancy SARS‐COV‐2 infection and fetal cardiac and hemodynamic changes
Authors: Xu Zi‐Hang , Zhu Xiao‐Dan , Yin Shan‐Yu , Bai Ji‐Yu , Pan Jin‐Hua , Zhou Lin‐Yu , Lu Dan‐Lei , Li Qiang , Zhou Ping‐Ping , Jiang Tian‐An 
Published: October 2024

AbstractAimOur objective was to investigate the impact on fetal cardiac function and fetal hemodynamics after recovery from severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) infection in early pregnancy.MethodsA prospective study involving 60 women in pregnancy who had recovered from a previous SARS‐CoV‐2 infection and 20 control wemen was performed. Between 11 and 14 weeks of pregnancy, women recovering from infection and controls underwent fetal ultrasound evaluation. Ultrasound parameters assessing cardiac function (TAPSE, MAPSE, E/A ratio) and hemodynamics (DV/S, DV‐D, DV‐A, DV‐TAMV, DV‐PI, DV‐PLI, DV‐PVIV) were measured.ResultsBased on ultrasound measurements, the median gestation age of the groups recovering from SARS‐CoV‐2 infection (RSI) was 12 (0.5) weeks, while the control group's was 12 (0.7) weeks (p = 0.76). The RSI group and the control group didn't indicate statistically significant differences in ultrasound measurements of cardiac function and hemodynamics (p > 0.05).ConclusionsAccording to our findings, the infection of SARS‐CoV‐2 in early pregnancy has no substantial influence on fetal cardiac function and fetal hemodynamics in pregnant women. However, the effect on mid‐pregnancy to late‐pregnancy is not yet known. Future studies will help elucidate the overall impact on fetal cardiac function of SARS‐CoV‐2 infection.
Changing Ideological Regimes: CEO Succession with A Shift in Political Ideology and New CEO Early Departure
Authors: Georgakakis Dimitrios , Souitaris Vangelis , Cannella Albert A. , Kalogeraki Olga , Peng Grace 
Published: October 2024

AbstractWe examine the effects of CEO succession coupled with a change in political ideology – when a conservative CEO is replaced by a liberal CEO or vice versa. We argue that in such CEO transitions, the new CEOs must alter their predecessors’ ideological imprints to imbue strategic leadership with their own values, which increases their executive job demands in the critical early years of their tenure and raises the likelihood of their early departure. We also suggest that this relationship is moderated by two strategic leadership interface (SLI) factors that influence the executive job demands these new CEOs face: (a) the retention of the ideologically incongruent predecessor as board chair, and (b) the ideological fit between the new CEO and the incumbent executive team. We first test our framework using data from 2286 CEO successions in S&P 1500 firms. We then conduct an experimental study to ensure causality and confirm executive job demands as a mediating mechanism underlying the relationship. Overall, our study advances the disruption theory of succession by shedding light on the deeply held mechanisms that lead to early failure in CEO transitions.
Like parents, like children… this is not always the case! A longitudinal study on the family transmission of intergroup contact
Authors: Pagano Maria , Zagrean Ioana , Barni Daniela , Crocetti Elisabetta 
Published: October 2024

AbstractDuring adolescence, opportunities for interethnic interactions can shape future attitudes toward diversity. However, it is unclear how family can influence adolescents' quality of contact in different life contexts. This study aims to fill this gap. A sample of 702 Italian adolescents (Mage = 15.61, SDage = 1.11, 48.58% girls) and their parents (615 mothers, Mage = 48.45, SDage = 4.34; 487 fathers, Mage = 51.22, SDage = 4.92) completed questionnaires at two time points. Cross‐lagged models indicated that adolescents' intergroup contact at T1 was associated with mothers' contact over time, mainly in structured (i.e., school and work) contexts. No significant associations were found regarding fathers' intergroup contact and unstructured contexts. These results shed new light on the process of family transmission during adolescence, particularly regarding intergroup dynamics.
Constraints on the impact history of the Apollo 16 landing site: Implications of soil‐like breccia noble gas records
Authors: Nottingham M. C. , Curran N. M. , Pernet‐Fisher J. , Burgess R. , Crawford I. A. , Gilmour J. D. , Tartèse R. , Joy K. H. 
Published: October 2024

AbstractThe Apollo 16 regolith breccia sample suite provides a record of lunar regolith formation from the basin‐forming epoch (~3.9 Ga) through to a time of declining impactor flux (~2 Ga). These rocks have been characterized into three groups: the “ancient,” “young,” and “soil‐like” regolith breccias on the basis of their petrographic characteristics, and, in the case of the “ancient” and “young” regolith breccias, noble gas inventory. This study investigates the as‐yet unexamined noble gas records of the “soil‐like” regolith breccias to understand more recent regolith evolution processes that occurred at the Apollo 16 landing site. The range of gas concentrations measured for each noble gas in these samples is comparable to those previously reported for the local Apollo 16 soils. The “soil‐like” regolith breccias were found to be more gas rich than the gas poor “young” and “ancient” regolith breccias, consistent with them having formed from comparatively mature soil(s). Our results further confirm the scientific value of lunar regolith breccias and bulk regolith samples as probes of the impact history and the space environment of the lunar surface across a wide range of time.
Prevalence of and potential risk factors for multiple resistance to acaricides inRhipicephalus (Boophilus) microplusticks: A survey in the state of Rio Grande Do Sul, Brazil
Authors: Ferreira Priscila Teixeira , Bidone Nathalia de Bem , Groff Fernando , da Silva Patrícia Silva , de Jesus Mariana Silveira , Pellegrini Debora da Cruz Payao , Doyle Rovaina Laureano , Reck José , Klafke Guilherme 
Published: October 2024

AbstractThe cattle tick Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Ixodida, Ixodidae) is responsible for significant economic losses in bovine production in tropical and subtropical regions worldwide. Control of this tick predominantly involves the use of chemical acaricides; however, their indiscriminate use has led to the selection of resistant populations. A survey on tick populations was conducted in the state of Rio Grande do Sul, in Brazil, to assess the prevalence of multiple resistance to acaricides in cattle farms. Additionally, questionnaires were administered to identify potential risk factors associated with multiple resistance to acaricides. In total, 176 farms with a bovine population of ≥40 cattle were randomly assigned for tick sampling. The resistance to six acaricidal compounds was investigated by bioassays. A larval packet test was performed for amitraz, chlorpyrifos, cypermethrin, fipronil and ivermectin. Fluazuron was screened using an adult immersion test. Multiple resistance to acaricides (i.e., resistance to three or more compounds) was detected in 173 samples, representing 98% of the total samples. Among these samples, 125 (71%) showed resistance to all six compounds tested. Additionally, we classified the resistance intensity into four levels (I to IV) based on the quartile distribution of the bioassay data. Ten samples (6%) showed high and very high levels (III and IV) of resistance to all six compounds tested. Three variables were significantly associated with multiple resistance to the six acaricides tested: (i) use of injectable acaricides to control ticks, (ii) application of more than five acaricide treatments per year, and (iii) farms with larger herds (≥232 animals). These results regarding widespread resistance and the emergence of multiple resistance to acaricides ticks are alarming and highlight the significant challenge of tick control in southern Brazil.
Clapping the nation, or, from a global pandemic to national imaginaries via local solidarities
Authors: Fox Jon 
Published: October 2024

AbstractIn the early days of the COVID‐19 pandemic, people in England stepped outside their doors once a week to clap the National Health Service. What does this have to do with nationalism? On the face of it, nothing much: clapping exercised local, and not, national solidarities. I will show, however, that local solidarities performed in clapping rituals led to the regeneration of national imaginaries via the symbols on display and the national institutions through which pandemic experiences were channelled. My argument has three parts. First, I show that helping practices during the pandemic shaped local solidarities that found collective expression through clapping. Second, I explain how the local experiences of clapping merged with national imaginaries when performed on a national canvas with symbols that marked an imagined community of national clappers. Third, I argue that clapping was subsumed into a nascent national imaginary via nationally scoped institutions that were exercised to fight the pandemic. Whilst the local has long been appreciated as a site and source for nationalism, I have added how non‐national local practices can also be constitutive of nationalism. A global pandemic led to national imaginaries via the local solidarities that were formed by clapping for carers.
Doing dams better? A case study of a proposed pumped hydro scheme at Lake Onslow, Central Otago
Authors: Phetpasak Khemaksone , Cant Garth , Challies Edward 
Published: October 2024

AbstractWater resource managers and Geographers share common interests in meeting Sustainable Development Goal Seven (universal access to affordable energy) and addressing climate change. Hydropower plays a key role but dams have environmental, social and cultural consequences. The Hydropower Sustainability Assessment Protocol (HSAP) aims to ensure that dams are built safely and potential impacts are understood. This study of a proposed pumped hydro scheme at Lake Onslow in Central Otago, New Zealand, considers the effectiveness of HSAP. Results reported here show that HSAP works well but that it can also be improved by including new groups of stakeholders and by widening the perception of risks.
Erector spinae plane block versus intravenous opioid for analgesia in pediatric cardiac surgery: A systematic review and meta‐analysis
Authors: Lombardi Rafael A. , Pereira Eduardo M. , Amaral Sara , Medeiros Heitor J. S. , Alrayashi Walid 
Published: October 2024

AbstractIntroductionThe erector spinae plane block (ESPB) has recently emerged as a regional anesthesia technique for perioperative pain management in pediatric cardiac surgery. However, evidence comparing its effectiveness with intravenous (IV) opioid‐based analgesia is limited. We aimed to evaluate and compare the analgesic efficacy of ESPB versus IV opioids in this setting.MethodsWe systematically reviewed and meta‐analyzed studies comparing ESPB with IV opioid analgesia in pediatric cardiac surgeries with midline sternotomy. Primary outcomes were intraoperative fentanyl consumption and intensive care unit (ICU) length of stay (LOS). Secondary outcomes included postoperative opioid consumption, time to first rescue analgesia, pain scores, postoperative vomiting and other complications, extubation time, and hospital LOS. Statistical analyses were performed using RStudio version 4.2.3.ResultsFive studies with 384 patients were included, with 178 receiving ESPB. ESPB significantly reduced intraoperative fentanyl use (MD −1.90 μg.kg−1; 95% CI −3.15 to −0.66 μg.kg−1; p = .003; I2 = 58%) and ICU LOS (MD ‐3.50 h; 95% CI ‐4.32 to −2.69 h; p < .0001; I2 = 0%). No significant differences were found in the remaining outcomes.ConclusionOur findings suggest the ESPB might be an important adjunct to enhancing analgesia for midline sternotomies in pediatric cardiac surgery, potentially reducing intraoperative opioid requirements and ICU LOS.PROSPERO RegistrationCRD 42024526961.
Genome‐Wide Analysis of the Phospholipase Ds in Perennial Ryegrass Highlights LpABFs‐LpPLDδ3 Cascade Modulated Osmotic and Heat Stress Responses
Authors: Yang Di , Wang Weiliang , Fang Zhengfu , Wu Simin , Chen Lili , Chen Jie , Zhang Wensong , Wang Feilong , Sun Tianxiao , Xiang Lin , Wang Yanping , Luo Hong , Chan Zhulong 
Published: October 2024

ABSTRACTThe phospholipase Ds (PLDs) are crucial for cellular signalling and play roles in plant abiotic stress response. In this study, we identified 12 PLD genes from the genome data of perennial ryegrass (Lolium perenne), which is widely used as forage and turfgrass. Among them, LpPLDδ3 was significantly repressed by ABA treatment, and induced by drought stress and heat stress treatments. The ectopic overexpression (OE) of LpPLDδ3 in Arabidopsis enhanced plant tolerance to osmotic and heat stress as demonstrated by an increased survival rate and reduced malondialdehyde (MDA) accumulation and electrolyte leakage (EL). Arabidopsis endogenous ABA RESPONSIVE ELEMENT BINDING FACTORs (ABFs) and heat stress responsive genes were elevated in LpPLDδ3 OE lines under osmotic and heat stress treatments. Additionally, overexpression of LpPLDδ3 in perennial ryegrass protoplasts could increase heat stress tolerance and elevate expression level of heat stress responsive genes. Moreover, LpABF2 and LpABF4 depressed the LpPLDδ3 expression by directly binding to its ABRE core‐binding motif of promoter region. In summary, LpPLDδ3 was repressed by LpABF2 and LpABF4 and positively involved in perennial ryegrass osmotic and heat stress responses.
HPV Vaccination Stages and Associated Factors Among Children of Immigrant Women
Authors: Lee Ja‐yin , Lee Hyeonkyeong , Kim Sue , Park Sohee , Chae Duckhee , Hong Hye Chong 
Published: October 2024

ABSTRACTObjectiveThis study aimed to identify key determinants by stage of implementation of human papillomavirus (HPV) vaccination among children of immigrant women in South Korea.DesignCross‐sectional descriptive study.SampleThe sample comprised 262 Chinese, Vietnamese, and Korean‐Chinese women with children living in South Korea.MethodsThe survey was conducted using self‐report questionnaires. The HPV vaccination levels in children were classified into four transition stages. Sequential logistic regression analysis was conducted to identify the factors affecting the transition of HPV vaccination status.ResultsSocial norms had the greatest influence on the intention to vaccinate. Perceived barriers were a significant factor associated with intention or initiation of vaccination, whereas perceived severity and susceptibility were associated with the intention and initiation stages, respectively. Upon the initiation of HPV vaccination, low perception of discrimination in healthcare was associated with continued vaccination.ConclusionGiven the importance of completing multiple doses of the HPV vaccine within a given timeframe, it is important to provide culturally appropriate interventions in stages to prevent dropouts.
Nursing and Social Justice—A Scoping Review
Authors: Tind Anitha M. , Hoeck Bente , Andersen Helle Elisabeth , Qvistgaard Laura Wacher , Delmar Charlotte 
Published: October 2024

ABSTRACTBackgroundNursing is historically, ethically, and theoretically mandated to champion social justice.ObjectiveTo investigate how the concept of “social justice” has been explored in nursing research regarding extent, range, and nature.MethodsThe five‐stage framework by Arksey and O'Malley was adopted, and JBI and PRISMA guidelines further informed the study. The search strategy comprised three steps: an initial search, a systematic search in several databases, and finally, a reference, citation, and gray literature search. A total of 55 studies meeting the inclusion criteria were included in the analysis.ResultsAlmost all the included studies were authored in the English‐speaking world. Most studies were published from 2014 onward, and qualitative methods were by far the most prominent. A total of 13 specific definitions or understandings of social justice were identified. Five themes were identified across the included studies: (1) education, (2) concept, (3) theory, (4) public health and community nursing, and (5) maternal and child health.ConclusionThe literature on social justice and nursing is limited, albeit growing. The conceptualization of social justice within nursing is becoming broader and more nuanced. Only a few studies have focused on specific patient groups or specialties.
Cost‐Utility Analysis of Teledermatology Units in Primary Care Centers Versus Face‐to‐Face Dermatology Consultations in the Hospital
Authors: Lopez‐Villegas Antonio , Bautista‐Mesa Rafael Jesus , Lopez‐Liria Remedios , Perez‐Heredia Mercedes , Hernandez‐Montoya Carlos Javier , Gutierrez‐Maldonado Maria Gador , Leal‐Costa Cesar , Peiro Salvador 
Published: October 2024

ABSTRACTObjectiveTo perform an economic evaluation to determine whether or not teledermatology (TD) units in primary care (PC) centers offer an alternative in terms of cost‐utility and cost per quality‐adjusted life years (QALYs) to conventional dermatology consultations (face‐to‐face dermatology [F‐F/D]) at the hospital from the perspective of the Public Health System (PHS) and the patients.MethodsThis is a randomized, controlled, nonblinded, and multicenter study. During 6 months, data from 450 patients (TD: 225 vs. F‐F/D: 225) were collected. From both perspectives, costs, quality of life, and costs per QALYs were analyzed. The QALY scores were estimated from the EuroQol‐5D‐5L (EQ5D‐5L) questionnaire responses.ResultsFrom the perspective of the PHS, the cost per patient was 53.04% lower in the TD group (p < 0.001). Hospital visits decreased by 72.43% in the TD group (p < 0.001). From the patients’ perspective, TD reduced costs per patient by 77.59% (p < 0.001). The cost per QALY was 63.34% higher in the F‐F/D group (p < 0.001). The TD group's total costs were 56.34% lower (p < 0.001). Furthermore, patients in the TD group gained 0.05 QALYs more than those in the F‐F/D group (p = 0.004).ConclusionsThis study shows that TD units in PC represent a significant cost‐effective alternative to conventional hospital follow‐up. To enhance TD in PC, it is important to introduce remote consultation platforms incorporating artificial intelligence for prediagnosis. This will enable general practitioners and nurses to make more accurate initial assessments. It is also crucial to provide thorough training to healthcare personnel using these technologies to ensure more efficient and personalized care. Public health nurses will benefit from gaining new skills in managing digital tools, which will help in the early identification of dermatological diseases and reduce unnecessary referrals to specialists. This will optimize resources and improve response times for patients.
Social Media Addiction and Cognitive Behavioral Physical Activity Among Adolescent Girls: A Cross‐Sectional Study
Authors: Sönmez Sari Ebru , Terzi Handan , Şahin Didem 
Published: October 2024

ABSTRACTObjectiveTo measure a multivariate analysis of social media addiction and cognitive‐behavioral physical activity associated with several sociodemographic characteristics in adolescent girls.Design and MethodsA cross‐sectional study. The sample consisted of adolescent girls studying in a vocational high‐school in the Middle‐Black‐Sea region in Türkiye (n = 333). A questionnaire, Social Media Addiction Scale‐for‐Adolescents (SMAS‐A), and Cognitive‐Behavioral Physical Activity Questionnaire (CBPAQ) were used to collect the data.ResultsThe mean age was 15.35 (SD = 1.15), and 29.4% were the ninth‐class students. Of the adolescent girls, 85.9% were social‐media users, 59.8% used the internet 2‐hours‐or‐more/daily, 67.9% declared themselves as moderately‐active. The mean scores of the SMAS‐A and the CBPAQ were 3.40 (SD = 1.61) and 21.03 (SD = 7.64), respectively. There was a significantly‐negative correlation between cognitive‐behavioral physical activity and social‐media addiction levels. The One‐Way MANOVA results showed significant differences in the academic level, family income, mother education, and physical activity measurement application usage affected to cognitive‐behavioral physical activity. Social media usage habit affected to the social media addiction level.ConclusionsDaily internet usage time and self‐declared physical activity level were the mutually affected factors. School nurses should act to improve healthy social media usage habits to promote well‐being and encourage the positive attitudes towards regular physical activity in this population.