bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic Resistance Control Program in Pediatric Hematology and Oncology Patients at Dr. Soetomo Hospital in 2006–2007
Authors: Andarsini Mia Ratwita , Ugrasena I Dewa Gede , Permono Bambang 
Published: March 2017

Antibiotic resistance has been increasing since the first years of the clinical usage. It caused by inappropriate usage and uncontrol of antibiotic drugs. Therfore an Antibiotic Resistance Control Program (ARCP) is needed to overcome the problem. The purpose of this study is to know microorganism pattern and evaluate antibiotic use. Phase 1 (before ARCP), retrospective study by medical record of pediatric hematology-oncology patients with suspision of infection and admitted at dr Soetomo Hospital from June–August 2006 was carried out. Phase 2 (during ARCP), a prospective observational study was done from November 2006 to January 2007. We were evaluated the isolated microorganism, quantity of antibiotic were determined by Defined Daily Doses (DDD)/100 patients-days, quality of antibiotics usage were assessed with Glyssen classification, and the cost calculation of antibiotic therapy. Twenty seven patients were enrolled in phase 1 and 28 patients in phase 2. Coagulase-negative Staphylococci and Acinetobacter Sp as isolated microorganism was reported. Phase 1, the most sensitive antibiotic was Cefoperazone-Sulbactam and the most resistant was Penicillin G. Phase 2, Meropenem was the most sensitive antibiotic and Cotrimoxazole was the most resistant antibiotic. The use of antibiotics were decreased 6 vs 12 and DDD/100 patients-days were 14.52 vs 45.04. There were improving of Glyssen classification. The cost calculation of antibiotics therapy were decreased. ARCP can improve antibiotic use in pediatric hematology-oncology patients.
THE MI GRAI NE- VERTI GO- PERI ODONTAL DI SEASE CONNECTION: EVIDENCE-BASED CASE AND VERIFICATION IN AN ANIMAL STUDY
Authors: Utomo Haryono 
Published: March 2017

Recently, two CNS disorders, migraine and anxiety have been recognized as being commonly associated with dizziness (Vertigo).These associations may be an expression of an etiological relationship, for example, dizziness caused by migraine, or dizziness causedby anxiety and termed as MARD. Chronic dizziness may become more disabling during the added stress of a migraine headache orpanic attack. In addition, dizziness occurred comorbidly with both migraine headache and anxiety disorders. Even though the etiologyof migraine had been suggested from trigeminal nerve sensitivity and neurogenic inflammation, its linking to periodontal disease thatinnervated by the same nerve was still uncertain. However, an animal study revealed that Porphyromonas gingivalis lipopolysaccharidestimulation was able to increase neurogenic inflammation. A male patient suffered with symptoms mimicking MARD for years andconcomitantly had chronic periodontitis. Scaling and root planning combined with the assisted drainage therapy resulted in instantdisappearing of most of the symptoms. This case report is to propose the mechanism of periodontal disease involvement in theetiopathogenesis of migraine and vertigo which could be treated with periodontal treatment. Regarding to remarkable result, it wasconcluded that periodontal disease could be a source of neurogenic and immunogenic inflammation which if not treated periodicallycould perpetuate symptoms mimicking MARD.
USING LEARNING VECTOR QUANTIZATION METHOD FOR AUTOMATED IDENTIFICATION OF MYCOBACTERIUM TUBERCULOSIS
Authors: Purwanti Endah , Widiyanti Prihartini 
Published: March 2017

In this paper, we are developing an automated method for the detection of tubercle bacilli in clinical specimens, principally the sputum. This investigation is the first attempt to automatically identify TB bacilli in sputum using image processing and learning vector quantization (LVQ) techniques. The evaluation of the learning vector quantization (LVQ) was carried out on Tuberculosis dataset show that average of accuracy is 91,33%.
THE UVEITIS – PERIODONTAL DISEASE CONNECTION IN PREGNANCY: CONTROVERSY BETWEEN MYTH AND REALITY
Authors: Sutedjo Widyawati , Prahasanthi Chiquita , Utomo Daniel Haryono 
Published: March 2017

Background: Recently, It had been recognized that oral infection, especially periodontal disease are potential contributing factors to a variety of systemic diseases, such as cardiovascular and cerebrovascular diseases, pregnancy problem, diabetes mellitus type 2, etc. However, the adverse effect of periodontal disease toward uveitis still not clearly understood especially if happens during pregnancy. Interestingly, in Indonesia, there is still a myth that pregnant women should not get any dental treatment, therefore, it may deteriorate periodontal disease during pregnancy. Purpose: to explain the possible connection between periodontal disease and uveitis and increasethe awareness of these problems during pregnancy that could be understood by doctor and laymen. Reviews: literatures revealed that dental infection can caused uveitis via metastatic spread of toxin and inflammatory mediators. Additionaly, more recent investigation reported that the neural system may also stimulated by oral infection. In the orofacial regions there's trigeminal nerve complex that also related to the orbital region, thus may also involved in the uveitis pathogenesis. The effects of periodonto pathogens toxins towardimmunocompetent cell and nerves had also been reported by researcher. Moreover, pregnant women are more susceptible to periodontal disease, therefore maintaining oral hygiene and dental monitoring is a mandatory.Conclusion: in woman who susceptible to uveitis, periodontal disease may exacerbate the symptoms especially in pregnancy. Therefore simple explanation about connection of oral infection-systemic diseases especially in pregnancy should be widespread among Indonesian people.
MODERN WOUND DRESSING FOR WOUND INFECTION: AN OVERVIEW
Authors: Rizani Novida 
Published: March 2017

When the tissue of skin is break means a wound is happens. To seal it, many choices of wound healing are available. Moist wound dressing can be better optional than the conservative ones. A bioactive agent that being added at the dressing in fact can increase healing rate of wound, moreover can subjugate wound infection caused by the pathogens, and also capable to prevent it. In this review, there are summary of modern moist wound healing, the wound pathogens, and some of sturdy bioactive agent for wound dressing. The treatment of wound infections using impregnated wound dressing by bioactive agent can also by antimicrobial agent that will striven against bacteria colonial.
TUBERCULOSIS COUNTER (TC) AS THE EQUIPMENT TO MEASURE THE LEVEL OF TB IN SPUTUM
Authors: Purwanda Fendy , Fibriawan Yufan , Sasmito Dyar , Rahmawati Fatkhunisa , Widiyanti Prihartini 
Published: March 2017

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. This disease is the third killer disease aftercardiovascular diseases and respiratory diseases, and is also he number one killer disease in a group of infectious diseases. This is partly due to the late handling and a non real time detection, both of which will inhibit the therapy which yields a large numberof microorganisms in the body, and will eventually complicate the recovery. Based on this phenomenon, we offered an alternativesolution for detecting the sum of microorganism using Tuberculosis Counter, a tool used to count the number of Tuberculosis bacteria in the patient's sputum. Technically, the patient's sputum preparat was screened using the TCS230 color sensor that was able to filter the color of the preparat. Tuberculosis bacteria in the stained sputum Ziehl-Niellsen preparat was colored red, while the other was colored blue. By utilizing these optical phenomena, the TCS230 color sensor was supposed to filter the red color in the preparat. By using regression equation measurement, we gained the equation which then correlated the bit value as an output of the sensor with the number of Tuberculosis bacteria. Then, the digitalization process yielded the real time and accurate data of Tuberculosis bacteria.
DAPSONE RESISTANCE IN A Mycobacterium leprae ISOLATE WITH TWO POINT MUTATIONS IN folP GENE FROM A LEPROSY PATIENT
Authors: Ardiaty Dinar , Wahyuni Ratna , Prakoeswa Cita , Abdullah Rasyidin , Agusni Indropo , Izumi Shinzo 
Published: March 2017

Drug resistance in leprosy is important for Leprosy Control Program, since the WHO-Multidrug regiment (MDT) has been used for global treatment of leprosy for more than two decades already. A Dapsone resistance case in a Multibacillary (MB) leprosy case is reported. The patient was diagnosed and treated in Tajuddin Chalid Hospital Makassar, South Sulawesi. Previously he was treated in a health center at South Sulawesi and was given a treatment for one year, before referred to the hospital. The leprosy skin lesions are still active with erythematous skin lesions and thickened ear lobe. Bacteriological examination was positive for Acid Fast Bacilli, the Bacterial Index was 3+ and the Morphological Index was 1%. The specimens of M.leprae isolation was sent to the Institute of Tropical Disease Surabaya for drug resistance study. Using the Lp1-2 and Lp3-4 nested primers, PCR test was positive for M.leprae.Sequencing result for folP gene showed a double mutation at codon 53 (ACC / Threonin ) which become (AGG / Arginine). Simultaneous mutation at two nucleotides at one codon has never been reported in Indonesia before and this phenomenon is important for leprosy control policy.
UPDATE MANAGEMENT DENGUE SHOCK SYNDROME IN PEDIATRIC CASES
Authors: Soegijanto Soegeng , Chilvia Eva 
Published: March 2017

Background: Since 1968 Dengue Virus Infection has been found in Indonesia, especially at Surabaya and Jakarta city. Firstly management of dengue virus infection very difficult to improve, therefore the higher mortality nearly 41,4% had been found but on the following years in five decades the mortality rates was becoming to decrease until 1,27% on 2011. Aim: To find the new management of Dengue Shock Syndrome to reach the lower fatality rate below 1%. Method: Until now to manage Dengue Shock Syndrome is very difficult, some cases can be improved but the other lost due to the late coming in the hospital and not involved in criteria diagnosis base on WHO 1997. To solve this problem WHO 2009 had made new criteria diagnosis Dengue Virus Infection focusing on early detection of severe Dengue Virus Infection especially Dengue Shock Syndrome. Result: On 2011 WHO had made an integrated criteria diagnosis base on WHO 2009 and WHO 1997. These criteria was focusing in Update management of Dengue Shock Syndrome in Pediatric Cases. Based on this action, this paper will improve clinical management to reach the lower mortality of Dengue Shock Syndrome in Community until CFR < 1%. Conclusion: By using integrated criteria of WHO 2009 and 1997, update management of Dengue Shock Syndrome in Pediatric cases, can improve clinical management to reach the lower mortality in community until CFR < 1%.
QUICK DIAGNOSIS OF JAPANESE ENCEPHALITIS FOR NEW DIAGNOSED EMERGING DISEASE USING PCR TECHNIQUE IN SURABAYA, INDONESIA
Authors: Matondang Muhammad Qushai Y. , Nasronudin Nasronudin , Aksono Eduardus Bimo , Lusida Maria Inge , Nastri Aldise Mareta , Fajar Nur Syamsiatul , Jannah Lilis Mundri 
Published: March 2017

Background: Japanese enchepalitis (JE) is a viral disease that considered as zoonotic disease, which transmitted through mosquito vectors that had JE virus. Mainly caused by the mosquito C. Tritaeniorhynchus (the most important vector is the mosquito Culex, which feeds on cattle in preference to human). JE virus disease can also cause disturbances in the central nervous system eg. brain, bone marrow, and meninges which has serious impact on public health. This disease has been reported from Japan, Korea, Taiwan, India, Myanmar, Thailand, Western Pacific and Southeast Asia to Indonesia. However, the incidence of this disease in Indonesia has not been well known in various animal species or humans. Aim: The purpose of this study is to develop rapid diagnostic examinations on patient diagnosed JE virus in Surabaya by using PCR (Polymerase Chain Reaction). Because, JE disease can lead to dead-end at the patient if not treated immediately. Method: The research methods, extraction method, PCR (1st RT-PCR and 2nd Nested PCR) are conducted using Japanese encephalitis PCR detection kit. Result: The results of the examination showed that 2 out of 17 people (11,765%) are positive with PCR bands 227 bp (basepair). This diagnostic technique to determine and to deal with early onset of the disease. Solutions for preventive actions can be started from the termination of the cycle vectors to vaccination measures. Conclusion: For his own medical factors given to reduce fever and swelling and reduce the pain.
Bacterial Colony In The Ventilator Circuit Of The Intensive Observation Unit at RSUD Dr. Soetomo Surabaya
Authors: Philia Philia 
Published: March 2017

ABSTRAKLatar belakang : Ventilator-associated pneumonia (VAP) adalah infeksi nosokomial tersering di unit perawatan intensif dan berperan besar sebagai penyebab morbiditas dan mortalitas. Ventilasi mekanik merupakan bagian penting dari unit perawatan intensif atau Intensive Care Unit (ICU). Namun demikian, ventilasi mekanik berhubungan dengan resiko terjadinya ventilator-associated pneumonia (VAP). Hubungan antara ventilasi mekanik dan kejadian pneumonia sudah dianggap sebagai suatu fakta, namun demikian bukti ilmiah untuk mendukung pernyataan ini masih kurang. Pada penelitian ini, peneliti mencoba menganalisa pertumbuhan koloni bakteri pada sirkuit ventilasi mekanik pada penderita yang mendapat bantuan ventilasi mekanik di Ruang Observasi Intensif RSUD Dr Soetomo Surabaya.Metode : Analisis observasional. 16 pasien yang dirawat dengan bantuan ventilasi mekanik di Ruang Observasi Intensif RSUD Dr Soetomo Surabaya, dilakukan pengambilan swab kultur sirkuit ventilator bagian inspirasi pada hari ke-0, di mana sirkuit ventilator belum terhubung dengan penderita, hari ke-3 dan 7. Koloni bakteri yang tumbuh dari hasil swab dilakukan pengukuran dan dibandingkan jumlah koloni bakteri yang tumbuh pada swab hari ke-0, 3, dan 7. Pada penelitian ini juga dilakukan analisa kesamaan jenis kuman pada sirkuit ventilator dan sputum penderita.Hasil : Pada penelitian ini didapatkan 2 sampel mengalami drop out dikarenakan didapatkan pertumbuhan bakteri pada hari ke-0. Dari hasil perbandingan pertumbuhan jumlah koloni bakteri pada sirkuit ventilator pasien pada pengamatan hari ke-3 dan ke-7 didapatkan perbedaan yang bermakna, sedangkan dari analisa kesamaan jenis bakteri pada sirkuit ventilator dan sputum penderita pada pengamatan hari ke-3 didapatkan hasil berbeda bermakna, sedangkan pada pengamatan hari ke-7 tidak berbeda bermakna.Diskusi : Pada penelitian ini didapatkan perbedaan bermakna antara pertumbuhan koloni bakteri sirkuit ventilator pada hari ke-3 dan hari ke-7, hal ini dapat disebabkan oleh kontaminasi sirkuit ventilator melalui humidifier, obat-obat yang diberikan secara nebulisasi, cairan kondensasi, dan kontaminasi dari sekresi penderita tersebut. Pada hasil analisis kesamaan jenis bakteri pada sirkuit ventilator dengan sputum penderita, didapatkan perbedaan yang signifikan antara jenis kuman pada sirkuit ventilator dengan sputum penderita. Banyak faktor yang mempengaruhi hasil penelitian ini, di antaranya kolonisasi pada orofaringeal, saluran pencernaan, kontaminasi tangan perawat, kontaminasi air, udara, dan peta kuman ruangan itu sendiri
Multisite Evaluation of APEX for Water Quality: II. Regional Parameterization
Authors: Nelson Nathan O. , Baffaut Claire , Lory John A. , Anomaa Senaviratne G.M.M.M. , Bhandari Ammar B. , Udawatta Ranjith P. , Sweeney Daniel W. , Helmers Matt J. , Van Liew Mike W. , Mallarino Antonio P. , Wortmann Charles S. 
Published: March 2017

Phosphorus (P) Index assessment requires independent estimates of long‐term average annual P loss from fields, representing multiple climatic scenarios, management practices, and landscape positions. Because currently available measured data are insufficient to evaluate P Index performance, calibrated and validated process‐based models have been proposed as tools to generate the required data. The objectives of this research were to develop a regional parameterization for the Agricultural Policy Environmental eXtender (APEX) model to estimate edge‐of‐field runoff, sediment, and P losses in restricted‐layer soils of Missouri and Kansas and to assess the performance of this parameterization using monitoring data from multiple sites in this region. Five site‐specific calibrated models (SSCM) from within the region were used to develop a regionally calibrated model (RCM), which was further calibrated and validated with measured data. Performance of the RCM was similar to that of the SSCMs for runoff simulation and had Nash–Sutcliffe efficiency (NSE) > 0.72 and absolute percent bias (|PBIAS|) < 18% for both calibration and validation. The RCM could not simulate sediment loss (NSE < 0, |PBIAS| > 90%) and was particularly ineffective at simulating sediment loss from locations with small sediment loads. The RCM had acceptable performance for simulation of total P loss (NSE > 0.74, |PBIAS| < 30%) but underperformed the SSCMs. Total P‐loss estimates should be used with caution due to poor simulation of sediment loss. Although we did not attain our goal of a robust regional parameterization of APEX for estimating sediment and total P losses, runoff estimates with the RCM were acceptable for P Index evaluation.Core Ideas
Regionally calibrated APEX produced very good estimates of site‐specific runoff.
Regionally calibrated APEX failed to adequately estimate sediment loss.
Regionally calibrated APEX P‐loss estimates were worse than site‐specific models.
APEX runoff estimates are adequate for rigorous evaluation of P Index runoff components.
APEX sediment loss estimates are unsuitable for evaluation of P Index.
Parametric study to mitigate fretting fatigue in dovetail joint of aeroengine compressor
Authors: Kumari Sunita , P V Srihari , A Bharatish , H N Narasimha Murthy 
Published: March 2017

Fretting fatigue is most likely to occur in the dovetail joint of aero engine compressor resulting in small amplitude displacement of a few micrometers. This leads to degradation of the material in the form of fatigue strength and corrosion. This paper reports optimal conditions of blade geometrical parameters such as flank length, flank angle and coefficient of friction in order minimize the failure due to fretting fatigue. ANOVA indicated that Von-mises stresses, deformation, contact pressure and sliding distance were influenced by coefficient of friction and flank angle. While deformation, contact pressure and sliding distance decreased with increase in coefficient of friction and increased with increase in flank angle and flank length. Von-mises stress increased with increase in coefficient of friction. Response surface methodology results indicated that the optimum value of Von-mises stress (328.24 MPa), deformation (153.87 µm), contact pressure (275.48 MPa) and sliding distance (80.66 µm) were found at coefficient of friction 0.35, flank angle 65° and flank length of 12 mm which were in agreement with those of grey relational analysis results.
The Role of Redox Dysregulation in the Inflammatory Response to Acute Myocardial Ischaemia-reperfusion Injury - Adding Fuel to the Fire
Authors: Hernandez-Resendiz Sauri , Chinda Kroekkiat , Ong Sang-Bing , Cabrera-Fuentes Hector , Zazueta Cecilia , Hausenloy Derek j. 
Published: March 2017

Background:
The inflammatory response to acute myocardial ischaemia/
reperfusion injury (IRI) plays a critical role in determining myocardial infarct (MI) size,
and subsequent post-MI left ventricular (LV) remodelling, making it a potential therapeutic
target for improving clinical outcomes in patients presenting with an acute myocardial infarction
(AMI). Recent experimental studies using advanced imaging and molecular techniques,
have yielded new insights into the mechanisms through which reactive oxygen species
(ROS) contribute to the inflammatory response induced by acute myocardial IRI - “adding
fuel to the fire”. The infiltration of inflammatory cells into the MI zone, leads to elevated
myocardial concentrations of ROS, cytokine release, and activation of apoptotic and
necrotic death pathways. Anti-oxidant and anti-inflammatory therapies have failed to protect
the heart against acute myocardial IRI. This may be, in part, due to a lack of understanding
of the time course, nature and mechanisms of the inflammation and redox dysregulation,
which occur in the setting of acute myocardial IRI.

Conclusion:
In this article, we examine the inflammatory response and redox dysregulation
induced by acute myocardial IRI, and highlight potential therapeutic options for targeting
redox dysregulation, in order to attenuate the detrimental effects of the inflammatory response
following an AMI, so as to reduce MI size and prevent heart failure.
THERMODINAMIC PARAMETERS ON THE SORPTION OF PHOSPHATE IONS BY MONTMORILLONITE
Authors: Jaslin Ikhsan , Endang Wijayanti , Sunarto Sunarto 
Published: March 2017

The sorption of phosphate by montmorillonite at 10, 30, and 50 oC were investigated aiming to mainly determine thermodynamic parameters for the formation of surface complexes in the adsorption of phosphate ions by montmorillonite. Data were collected by adsorption edge experiments investigating the effect of pH, adsorption isotherms enabling the effect of sorbate concentration, and acid-base titration calculating protons released or taken up by adsorption process. Data analysis was carried out using surface complexation model to fit the data collected in this study using the parameters obtained from previous study, as well as to calculate the values of ΔH and ΔS. Previous study reported that phosphate ions formed two outer-sphere surface complexes with active sites of montmorillonite through hydrogen bonding. In the first complex, [(XH)0– H2L─]─, the phosphate was held to permanent-charge X─ sites on the tetrahedral siloxane faces, and the second complex, [[(SO─)(SOH)]– – [H2L]─] 2─ was formed through the interaction between the phosphate and variable charge surface hydroxyl groups at the edges of montmorillonite crystals and on the octahedral alumina faces. The values of ΔH for the first and second reactions are 39.756 and 3.765x10-7 kJ mol‒1 respectively. Since both reactions have positive enthalpy values, it can be concluded that the reactions are endothermic. Large energy for the first reaction is needed by X─ sites (permanent negatively charge sites of montmorillonite) to be partially desolvated, on which K+ or other surface cations are replaced by H+ ions in the surface protonated process, and are then ready to interact phosphate ions in the solution. Small values of ΔH for the second reactions indicates that hydrogen bonds formed by phosphate and SOH sites in the second reaction are easily broken out, and the phosphate can easily desorbed from the surface. The values of ΔS for the first and second reactions are 122.523 and 2.393 x10-2 J K‒1 mol‒1, which are greater than -10 kJ mol‒1 and indicates that the surface reactions occurs through dissociative mechanisms.Keywords: montmorillonite, adsorption edge, extended constant capacitance, surface complexation model, enthalpy, reaction mechanisms
THE EFFECT OF NONLINEAR DAMPING TO A DYNAMICAL SYSTEM WITH CENTER PHASE PORTAIT
Authors: Kurniawan Kus Prihantoso , Arifah Husna 
Published: March 2017

This paper discusses the effect of nonlinear damping to a 2-dimesional system that has center phase portrait. The phase portraits of the damped system are drawn for 3 different values of parameter. These phase portraits stand as the numerical proof of phase portrait change. To prove the change analiticaly, we use the theorem that guarantee the existence of periodic solution. The result shows that nonlinear damping changes the phase portrait topologically. It means that the system undergoes a generalized Hopf bifurcation. Keywords: generalized Hopf bifurcation, center phase portrait, periodic solution