bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARAÇÃO ENTRE DIFERENTES TÉCNICAS DIGITAIS PARA ELABORAÇÃO DO MODELO DIGITAL DO TERRENO E DA CARTA DE DECLIVIDADES, COM APLICAÇÃO EM MAPEAMENTO GEOLÓGICO-GEOTÉCNICO E ANÁLISE AMBIENTAL
Authors: Liporaci Silvana Ribeiro , Rohm Sérgio Antonio , Pedro Fábio Giardini , Cereda Junior Abimael 
Published: January 2017

Este trabalho enfoca a avaliação de técnicas e procedimentos para a obtenção
de produtos digitais relativos a Modelo Digital do Terreno, à Perspectiva Tridimensional
do Terreno e à Carta de Declividades, por vários métodos acoplados aos softwares
SURFER e aos Sistemas de Informações Geográficas (IDRISI 3.2 e SPRING 3.5). As
técnicas testadas foram aplicadas para demonstrar a importância e a utilização de recursos
de geoprocessamento, na geração de alternativas de visualização tridimensional da área
de estudos. Isto tem como meta direcionar e otimizar os trabalhos de campo do mapeamento geológico-geotécnico de detalhe, na escala 1:10.000, visando a análise
ambiental. Discute-se assuntos relacionados principalmente à modelagem de processos
potencializadores de riscos associados a enchentes e inundações, decorrentes da relação
entre erosão e assoreamento, nas nascentes da Bacia do Rio Monjolinho, onde está
inserida uma cidade de médio porte, que é São Carlos (SP - Brasil).
FUNGOS FILAMENTOSOS ISOLADOS DE FOLHAS EM DECOMPOSIÇÃO NA REPRESA DE GUARAPIRANGA, SÃO PAULO, SP
Authors: Wellbaum Christian , Schoenlein-Crusius Iracema Helena , Malosso Elaine , Tauk-Tornisielo Sâmia Maria 
Published: January 2017

No presente estudo, são apresentados os resultados sobre o levantamento da diversidade da micota das folhas em decomposição, de sete coletas bimestrais (agosto de 1997 a agosto de 1998) em ambientes terrestre e aquático localizados nas seis estações de coleta às margens da Represa do Guarapiranga, no município de São Paulo, SP. O isolamento dos fungos foi realizado através da técnica de lavagem de discos de folhas que foram plaqueados em meio de cultura (batata-dextrose-ágar, BDA). Macro e micronutrientes foram determinados nas alíquotas remanescentes das folhas, e durante as coletas foram determinados o pH, condutividade, oxigênio dissolvido (OD) e a temperatura da água. Os fungos associados às folhas em
decomposição do ambiente terrestre (46 táxons) e do aquático (54 táxons) apresentaram elevada similaridade (68%) entre si. A tendência encontrada foi de que as micotas abrangeram grupos considerados cosmopolitas, com predomínio de representantes de Penicillium, Fusarium, Trichoderma e Pestalotiopsis. A possível influência dos fatores climáticos foi diferente sobre os dois ambientes. Observou-se a existência de três efeitos antrópicos diretos sobre os teores de nutrientes de folhas, bem como sobre a diversidade e quantidade de fungos: o despejo de poluentes orgânicos, a aplicação de sulfato de cobre nas águas e a modificação da vegetação da represa.
Hydrogeochemical evolution of mesozoic aquifers in the southern Paraná basin in western Rio Grande do Sul State, Brazil
Authors: Teixeira Guilherme Vargas , Viero Antonio Pedro 
Published: January 2017

A região oeste do Rio Grande do Sul é marcada por sucessivas crises no abastecimento durante a estação seca. Estudos hidrogeológicos, hidroquímicos e estruturais foram feitos para entender a dinâmica do fluxo subterrâneo dos aquíferos da região. Os aqüíferos do estudo são o Sistema Aquífero Guarani (SAG) e o Sistema Aquífero Serra Geral (SASG). Aproximadamente 90% dos poços capturam água exclusivamente no SASG, enquanto 10% captam água no SAG. O SAG consiste de quatro unidades sedimentares hidroestratigráficas: Botucatu, as Formações Guará e Pirambóia e o Grupo Rosário do Sul, enquanto o SASG consiste de uma unidade hidroestratigráfica, a Formação Serra Geral. O principal objetivo deste estudo é a caracterização hidrogeoquímica dos aquíferos juro-cretáceos da região. Os dados hidroquímicos são do banco de dados do SIAGAS, pertencente ao Serviço Geológico do Brasil (CPRM). Análises estatísticas por componentes principais e método de agrupamento por distância identificaram três grupos, confirmados pelos diagramas de dispersão. O grupo 1 percola apenas no SASG, enquanto os grupos 2 e 3 mostram enriquecimento em sódio indicando mistura com águas profundas provenientes de aqüíferos confinados sedimentares da bacia do Paraná. O enriquecimento de sódio resulta da troca de cátions em argilas. Além do sódio, íons como sulfato, cloreto e fluoreto aparecem com concentrações significativas em muitos poços. Eles podem ter sido originados da Formação Irati, que está estratigraficamente abaixo do SAG e do SASG.
Socioeconomic Characteristics, Oral Care Habits and Oral Health-Related Quality of Life among the Parents of Pre-School Children in Klaipėda
Authors: Andruškienė Jurgita , Barsevičienė Šarūnė , Dvarionaitė Lijana , Grubliauskienė Jūratė , Mažionienė Asta 
Published: January 2017

AbstractThere is a lack of data about oral health-related quality of life (OHRQoL) among the parents of pre-school children, especially in Lithuania and the relationships among socio-economic status, oral care habits and OHRQoL. Research questions: is OHRQoL influenced by socioeconomic status or oral care habits? Research focus – oral health-related quality of life among the parents of pre-school children. The aim of this study was to analyze the relationships among socioeconomic status, oral care habits and oral helath-related quality of life among the parents of pre-school children in Klaipeda. The study sample consisted of 375 parents (mother or father) of pre-school children. The questionnaire survey was conducted at randomly selected 23 kindergartens in Klaipeda city. The questionnaire consisted of sociodemographic and oral care habits questions. All the participants were examined by self-administered OIDP questionnaire, which measured oral impacts on physical, psychological and social aspects of daily performances. The highest overall impact on OHRQoL among the parents of pre-school children was observed in the domain of Carrying out major work or role (73.0), the lowest one in the Eating and enjoying food (25.74) domain. Mean OIDP score was significantly higher among the parents whose socioeconomic status was low (35.44), reflecting poorer OHRQoL, as compared with high (8.07) socioeconomic status. Parents with poor oral care habits significantly more frequently were affected (79.2%) in Smiling, laughing domain, as compared to the parents whose oral care habits were good (20.8%). Lower socioeconomic status and poorer oral care habits were related with worsened oral health-related quality of life, especially in the area of psychological performances.
445-nm diode laser-assisted debonding of self-ligating ceramic brackets
Authors: Stein Steffen , Kleye Alexander , Schauseil Michael , Hellak Andreas , Korbmacher-Steiner Heike , Braun Andreas 
Published: January 2017

Abstract

Objectives:
This study determined the influence of irradiation on aesthetic ceramic brackets with a novel 445-nm diode laser prior to debonding on the bracket failure mode.

Materials and methods:
Thirty ceramic brackets (In-Ovation® C, GAC) were standard-bonded to the oral and buccal planed and polished enamel surfaces of 15 caries-free human 3rd molars. Prior to study-blinded debonding, the brackets in the laser group were irradiated with the diode laser (SIROLaser Blue®, Sirona), while the irradiation was simulated within the conventional group. To determine the degree of enamel fractures and the adhesive remnant index (ARI) before debonding (T0), after debonding (T1) and after removal of the remaining composite using a rotating fraise (red ring, Comet) (T2), micrographs of the enamel surface at 10-fold and 20-fold magnifications were taken. Additionally, the enamel surface was investigated using seven randomly chosen samples from each group at every time point by SEM at 200-fold and 500-fold magnifications.

Results:
In the laser group, the ARI-score was statistically significantly reduced (p<0.05) at 10-fold and 20-fold magnifications compared to the conventional group, while enamel fractures were not found at any magnification in either group at T1. Enamel fractures and grinding marks were increasingly found in the conventional group by SEM at T2.

Conclusion:
Irradiation with the novel diode laser prior to debonding of ceramic brackets significantly changes bonding failure in terms of less remaining adhesive. This is of clinical importance as the risk of enamel fractures and chair time can be reduced.
Association between plasma proANP and hyperuricemia in Chinese Han women: a cross-sectional study
Authors: Zhu Zhengbao , Zhang Qiu , Peng Hao , Zhong Chongke , Liu Yan , Huangfu Xinfeng , Tian Yunfan , Chao Xiangqin , Jin Jianhua , Zhang Yonghong 
Published: January 2017

AbstractBackground:Association between pro-atrial natriuretic peptide (proANP) and hyperuricemia has not yet been investigated in population. This study aimed to examine the association in Chinese Han women.Methods:We measured plasma proANP, serum uric acid, and other traditional biomarkers in 1360 women older than 30 years residing in the Gusu district of Suzhou City. Association between plasma proANP and hyperuricemia was analyzed in women aged ≥45 years and those aged <45 years, respectively.Results:In women aged ≥45 years, the odds ratio (OR) [95% confidence interval (CI)] of hyperuricemia with high proANP (over the median) was 0.57 (0.34–0.97) compared to those with low proANP (p=0.040). After adjustment for age and other potential covariates, a high plasma proANP was associated with a decreased risk of hyperuricemia in women aged ≥45 years (OR 0.40; 95% CI, 0.19–0.84), when the highest and lowest categories were compared. In contrast, there was no association between plasma proANP and hyperuricemia in women aged <45 years. We did not observe a significant interaction between age and proANP (pinteraction=0.113). Sensitivity analyses further confirmed these age-specific findings.Conclusions:Plasma proANP was significantly and inversely associated with hyperuricemia in Chinese Han women aged ≥45 years. This study suggests that an increased plasma proANP should be a protective factor of hyperuricemia among middle-aged and old women.
The use of liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of antibiotics in cancer patients
Authors: El-Najjar Nahed , Jantsch Jonathan , Gessner André 
Published: January 2017

AbstractCancer remains a leading cause of mortality and morbidity worldwide. In addition to organ failure, the most frequent reasons for admission of cancer patients to intensive care units (ICU) are: infections and sepsis. As critically ill, the complexity of the health situation of cancer patients renders the standard antimicrobial regimen more complex and even inadequate which results in increased mortality rates. This is due to pathophysiological changes in the volume of distribution, increased clearance, as well as to organ dysfunction. While in the former cases a decrease in drug efficacy is observed, the hallmark of the latter one is overdosing leading to increased toxicity at the expense of efficacy. Furthermore, an additional risk factor is the potential drug-drug interaction between antibiotics and antineoplastic agents. Therefore, therapeutic drug monitoring (TDM) is a necessity to improve the clinical outcome of antimicrobial therapy in cancer patients. To be applied in routine analysis the method used for TDM should be cheap, fast and highly accurate/sensitive. Furthermore, as ICU patients are treated with a cocktail of antibiotics the method has to cover the simultaneous analysis of antibiotics used as a first/second line of treatment. The aim of the current review is to briefly survey the pitfalls in the current antimicrobial therapy and the central role of TDM in dose adjustment and drug-drug interaction’s evaluation. A major section is dedicated to summarize the currently published analytical methods and to shed light on the difficulties and potential problems that can be encountered during method development.
The serum concentrations of leptin and MCP-1 independently predict low back pain duration
Authors: Lippi Giuseppe , Dagostino Concetta , Buonocore Ruggero , Aloe Rosalia , Bonaguri Chiara , Fanelli Guido , Allegri Massimo 
Published: January 2017

AbstractBackground:Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP.Methods:The study population consisted of 104 patients diagnosed with LBP (52 non-persistent and 52 persistent) and 52 healthy subjects with no LBP. Blood samples were collected for assessment of adiponectin, leptin, monocyte chemoattractant protein-1 (MCP-1) and C reactive protein (CRP). The duration of LBP was categorized as “no pain”, “non-persistent LBP” and “persistent LBP”.Results:Higher values of CRP and lower concentrations of both leptin and MCP-1 were found in LBP patients compared to controls, whereas adiponectin did not differ among groups. MCP-1 was also lower in patients with non-persistent than in those with persistent LBP. Age, leptin (relative risk, 11.8; 95% CI, 3.9–35.8) and MCP-1 (relative risk, 2.7; 95% CI, 1.7–4.4) were independently associated with presence and duration of LBP. The combination of age, leptin and MCP-1 predicted 61% of the risk of LBP duration. The area under the curve of MCP-1 for distinguishing persistent from non-persistent LBP was 0.65 (95% CI, 0.54–0.76).Conclusions:Then results of our study suggest that leptin and MCP-1 may be promising biomarkers for diagnosis of acute LBP and its risk to become chronic.
Biomarkers of acute kidney injury: the pathway from discovery to clinical adoption
Authors: Kashani Kianoush , Cheungpasitporn Wisit , Ronco Claudio 
Published: January 2017

Abstract
Acute kidney injury (AKI) is a common complication of critical illnesses and has a significant impact on outcomes, including mortality and morbidities. Unfortunately, apart from prophylactic measures, no effective treatment for this syndrome is known. Therefore, early recognition of AKI not only can provide better opportunities for preventive interventions, but also opens many gates for research and development of effective therapeutic options. Over the last few years, several new AKI biomarkers have been discovered and validated to improve early detection, differential diagnosis, and differentiation of patients into risk groups for progressive renal failure, need for renal replacement therapy (RRT), or death. These novel AKI biomarkers complement serum creatinine (SCr) and urine output, which are the standard diagnostic tools for AKI detection. In this article, we review the available literature on characteristics of promising AKI biomarkers that are currently the focus of preclinical and clinical investigations. These biomarkers include neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), liver-type fatty acid-binding protein, interleukin 18 (lL-18), insulin-like growth factor-binding protein 7, tissue inhibitor of metalloproteinase 2 (TIMP-2), calprotectin, urine angiotensinogen (AGT), and urine microRNA. We then describe the clinical performance of these biomarkers for diagnosis and prognostication. We also appraise each AKI biomarker’s advantages and limitations as a tool for early AKI recognition and prediction of clinical outcomes after AKI. Finally, we review the current and future states of implementation of biomarkers in the clinical practice.
From bacteria to chloroplasts: evolution of the chloroplast SRP system
Authors: Ziehe Dominik , Dünschede Beatrix , Schünemann Danja 
Published: January 2017

Abstract
Chloroplasts derive from a prokaryotic symbiont that lost most of its genes during evolution. As a result, the great majority of chloroplast proteins are encoded in the nucleus and are posttranslationally imported into the organelle. The chloroplast genome encodes only a few proteins. These include several multispan thylakoid membrane proteins which are synthesized on thylakoid-bound ribosomes and cotranslationally inserted into the membrane. During evolution, ancient prokaryotic targeting machineries were adapted and combined with novel targeting mechanisms to facilitate post- and cotranslational protein transport in chloroplasts. This review focusses on the chloroplast signal recognition particle (cpSRP) protein transport system, which has been intensively studied in higher plants. The cpSRP system derived from the prokaryotic SRP pathway, which mediates the cotranslational protein transport to the bacterial plasma membrane. Chloroplasts contain homologs of several components of the bacterial SRP system. The function of these conserved components in post- and/or cotranslational protein transport and chloroplast-specific modifications of these transport mechanisms are described. Furthermore, recent studies of cpSRP systems in algae and lower plants are summarized and their impact on understanding the evolution of the cpSRP system are discussed.
Leading-Effect, Risk-Taking and Sabotage in Two-Stage Tournaments: Evidence from a Natural Experiment
Authors: Mueller-Langer Frank , Andreoli-Versbach Patrick 
Published: January 2017

AbstractExisting theory suggests that three “order effects” may emerge in multi-stage tournaments with information feedback. First, participants adjust effort across stages, which could advantage the leading participant who faces a larger “effective prize” after an initial victory (leading-effect). Second, leading participants might engage in sabotage activities to protect their lead thereby decreasing the rivals’ output. Finally, participants lagging behind may increase risk at the final stage as they have “nothing to lose” (risk-taking). The expected order effects based on existing theory cannot be supported empirically in a natural experiment setting, where professional teams compete in a two-stage tournament with asymmetric initial conditions and clear incentives.
Changes of thyroid hormonal status in patients receiving ketogenic diet due to intractable epilepsy
Authors: Kose Engin , Guzel Orkide , Demir Korcan , Arslan Nur 
Published: January 2017

AbstractBackground:Ketogenic diet (KD), which is high in fat and low in carbohydrates, mimics the metabolic state of starvation and is used therapeutically for pharmacoresistant epilepsy. It is known that generation of triiodothyronine (T3) from thyroxine (T4) decreases during fasting periods. The aim of this study was to evaluate the thyroid function of children receiving KD for at least 1 year due to drug-resistant epilepsy.Methods:A total of 120 patients [63 males, 52.5%; mean age 7.3±4.3 years, median interquartile range (IQR): 7.0 (4–10 years)] treated with KD for at least 1 year were enrolled. Seizure control, side effects, and compliance with the diet were recorded, and free T3, free T4, and thyroid-stimulating hormone (TSH) levels were measured at baseline and at post-treatment months 1, 3, 6, and 12. The Mann-Whitney U-test, repeated measures analysis of variance (ANOVA) with post-hoc Bonferroni correction, and logistic regression analysis were used for data analysis.Results:Hypothyroidism was diagnosed and L-thyroxine medication was initiated for eight, seven and five patients (20 patients in total, 16.7%) at 1, 3, and 6 months of KD therapy, respectively. Logistic regression analysis showed that baseline TSH elevation [odds ratio (OR): 26.91, 95% confidence interval (CI) 6.48–111.76, p<0.001] and female gender (OR: 3.69, 95% CI 1.05–12.97, p=0.042) were independent risk factors for development of hypothyroidism during KD treatment in epileptic children.Conclusions:KD causes thyroid malfunction and L-thyroxine treatment may be required. This is the first report documenting the effect of KD treatment on thyroid function. Thyroid function should be monitored regularly in epileptic patients treated with KD.
High predictability of impaired glucose tolerance by combining cardiometabolic screening parameters in obese children
Authors: Groot Cornelis Jan de , Grond Jeroen van der , Delgado Yosine , Rings Edmond H.H.M. , Hannema Sabine E. , van den Akker Erica L.T. 
Published: January 2017

AbstractBackground:There is debate on which overweight and obese children should be screened for the presence of impaired glucose tolerance (IGT) by oral glucose tolerance testing (OGTT). The objective of the study was to identify risk factors predictive of the presence of IGT.Methods:In a cohort of overweight children, who underwent OGTT, we determined the association of anthropometric and laboratory parameters with IGT and whether combining parameters improved the sensitivity of screening for IGT.Results:Out of 145 patients, IGT was present in 11, of whom two had impaired fasting glucose (IFG). Elevated blood pressure (p=0.025) and elevated liver enzymes (p=0.003) were associated with IGT, whereas IFG was not (p=0.067), screening patients with either one of these parameters predicted IGT with a high sensitivity of 1.00, and a number needed to screen of 5.7.Conclusions:Screening all patients with either IFG, presence of elevated blood pressure and elevated liver enzymes, significantly increases predictability of IGT compared to using IFG alone.
Polyheterocycle-carbohydrate chimeras: photoassisted synthesis of 2,5-epoxybenzoxacines and 2,5-epoxybenzazocine scaffolds and their postphotochemical hydroxylations
Authors: Sai Reddy D. , Mukhina Olga A. , Cole Cronk W. , Kutateladze Andrei G. 
Published: January 2017

Abstract
Photoassisted synthesis of complex polyheterocyclic molecular architectures via excited state intramolecular proton transfer (ESIPT) is for the first time implemented for the reactions of o-keto phenols. This adds the 2,5-epoxybenzoxacine core to the previously obtained 2,5-epoxybenzazocine cores and offers rapid access to primary photoproducts which lend themselves to diverse yet simple postphotochemical modifications to further grow the complexity of the target structures, specifically – access to polyheterocycle-carbohydrate chimeras containing up to five contiguous stereogenic centers and benzazocine or benzoxacine heterocyclic cores.
Relationships between Physical Fitness Components among Slovak High School Students
Authors: Turek Milan , Ruzbarsky Pavel , Kokinda Marek , Smerecka Viera , Jancosek Mario , Kandrac Robert 
Published: January 2017

Abstract

Introduction.
The purpose of the study was to assess physical fitness based on using FITNESSGRAM test battery in Slovak high school students.

Material and methods.
The reference sample consisted of 1,016 high school students from schools located in the Prešov self-governing region. Students were tested for physical fitness components using selected Fitnessgram test items. In addition, students performed 20-meter endurance shuttle run to determine their level of cardiorespiratory fitness and 10-second jumping test on a jumping ergometer to determine their lower-body explosive power.

Results.
Results of one-way ANOVA showed significant differences for curl-up test (p = .012) between 15-year-old boys and 18-year-old boys. There were no differences between boys living in rural areas and their age-matched counterparts living in urban areas. Contrary to boys, girls from rural areas had higher level of abdominal strength (p = .046; d = .19). In the 20-meter endurance shuttle run, boys averaged 448.87 meters more than girls.

Conclusions.
This study enables to create norm-referenced standards, which through their content will to a great extent indicate the measures of physical fitness.