bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model
Authors: Zhang Zhong-Hao , Wu Qiu-Yan , Zheng Rui , Chen Chen , Chen Yao , Liu Qiong , Hoffmann Peter R. , Ni Jia-Zuan , Song Guo-Li 
Published: January 2017

Tau pathology was recently identified as a key driver of disease progression and an attractive therapeutic target in Alzheimer's disease (AD). Selenomethionine (Se-Met), a major bioactive form of selenium (Se) in organisms with significant antioxidant capacity, reduced the levels of total tau and hyperphosphorylated tau and ameliorated cognitive deficits in younger triple transgenic AD (3xTg-AD) mice. Whether Se-Met has a similar effect on tau pathology and the specific mechanism of action in older 3xTg-AD mice remains unknown. Autophagy is a major self-degradative process to maintain cellular homeostasis and function. Autophagic dysfunction has been implicated in the pathogenesis of multiple age-dependent diseases, including AD. Modulation of autophagy has been shown to retard the accumulation of misfolded and aggregated proteins and to delay the progression of AD. Here, we found that 3xTg-AD mice showed significant improvement in cognitive ability after a 3-month treatment with Se-Met beginning at 8 months of age. In addition to attenuating the hyperphosphorylation of tau by modulating the activity of Akt/glycogen synthase kinase-3β and protein phosphatase 2A, Se-Met-induced reduction of tau was also mediated by an autophagy-based pathway. Specifically, Se-Met improved the initiation of autophagy via the AMP-activated protein kinase–mTOR (mammalian target of rapamycin) signaling pathway and enhanced autophagic flux to promote the clearance of tau in 3xTg-AD mice and primary 3xTg neurons. Thus, our results demonstrate for the first time that Se-Met mitigates cognitive decline by targeting both the hyperphosphorylation of tau and the autophagic clearance of tau in AD mice. These data strongly support Se-Met as a potent nutraceutical for AD therapy.SIGNIFICANCE STATEMENTSelenium has been widely recognized as a vital trace element abundant in the brain with effects of antioxidant, anticancer, and anti-inflammation. In this study, we report that selenomethionine rescues spatial learning and memory impairments in aged 3xTg-AD mice via decreasing the level of tau protein and tau hyperphosphorylation. We find that selenomethionine promotes the initiation of autophagy via the AMPK–mTOR pathway and enhances autophagic flux, thereby facilitating tau clearancein vivoandin vitro. We have now identified an additional, novel mechanism by which selenomethionine improves the cognitive function of AD mice. Specifically, our data suggest the effect of selenium/selenomethionine on an autophagic pathway in Alzheimer's disease.
Combinatorial actions of bacterial effectors revealed by exploiting genetic tools in yeast
Authors: Huett Alan 
Published: January 2017

While yeast has been extensively used as a model system for analysing protein–protein and genetic interactions, in the context of bacterial pathogenesis, the use of yeast‐based tools has largely been limited to identifying interactions between pathogen effectors and host targets. In their recent work, Ensminger and colleagues (Urbanus et al, ) use the combinatorial power of yeast genetics to systematically screen all known Legionella pneumophila effector proteins for effector–effector interactions. They provide new insights into how bacterial effectors balance host cell perturbation and describe mechanisms used by “meta‐effectors” to directly modulate target effector activity.
Post-Islamism and the Remaking of Islamic Public Sphere in Post-reform Indonesia
Authors: Ansor Muhammad 
Published: January 2017

The following essay examines post-Islamism in post-reform Indonesia by focusing on contestation in the remaking of the Islamic public sphere. I argue that the public sphere is not only an arena of contestation between Islamists and secularists, but also among the proponents of social movements that mobilize Islam as a source of legitimacy. In the first section, I present a brief review of the notion of post-Islamism and Islamic public sphere as categories of analysis to examine the dynamics of Islam in Indonesia. Next, I explain the topography of Islamic movements in contemporary Indonesia. Post-Islamist contestation in the remaking of the Indonesian Islamic public sphere is examined in the third section. It is limited to four topics, i.e. the dynamics of Muslim intellectual movements, post-Islamist women’s activism and piety movements, Islamic visibility in pop culture, and discourses of shari’a implementation in Aceh. Finally, the article concludes that the dynamics of Indonesian post-Islamists and their contestation are not only helping to strengthen the praxis of democracy in the post-reform era, but they are also diverting public attention from the temptation of radicalism and violence in the name of religion.DOI: 10.15408/sdi.v23i3.2412
Social bias within the institution of hired domestic care: global interactions and migration
Authors: Uhde Zuzana 
Published: January 2017

O artigo apresenta uma análise crítica da instituição da cuidado doméstico contratado no contexto do capitalismo global. A autora começa por esboçar o contexto da sociedade moderna tardia nas regiões europeias e anglo-americanas em que as desigualdades globais e o aumento intensivo do capitalismo reforçam um modelo de mercado de cuidados e, consequentemente, também a instituição de cuidados domésticos contratados que cada vez mais envolve migrantes. Do ponto de vista da teoria crítica, ela analisa as possíveis variações das relações entre trabalhador doméstico e empregador dentro da instituição de cuidado doméstico contratado. E ela conclui que a instituição de cuidados domésticos contratados envolve necessariamente preconceito social que reproduz as desigualdades sociais, bem como a tradicional divisão do trabalho de gênero e a servidão institucionalizada.
Representações de gênero e literatura infantil: paradidáticos em análise
Authors: Da Costa Fábio Soares , Dos Santos Andreia Mendes 
Published: January 2017

A adoção de livros paradidáticos para a educação infantil é uma prática identificada na maioria das escolas brasileira, pois é útil como uma estratégia de ação educativa, visando uma complementaridade das temáticas dos livros didáticos. Neste contexto, analisamos quatro livros paradidáticos: Os músicos de Bremen (Ruth Rocha); Uma trança dourada (Tatiana Belinky); A rainha rabiscada (Sylvia Orthof); e O pavão abre e fecha (Ana Maria Machado). Optamos, teórico-metodologicamente, pela a análise do discurso crítica, a partir Norman Fairclough (2001), Eliseo Verón (2004) e Laerte Magalhães (2003), e objetivamos identificar as representações e discursos de gênero construídas nessa literatura. Assim, observamos a existência de esteriotipais de dualização entre os sexos, um modelo patriarcal, romantismo e estetização corporal.
Mechanisms of Controlled Growth Of Metallic Nanocrystals
Authors: Puntes Victor F , Konya Zoltan , Erdonmez Can , Zhu J. , Somorjai Gabor A. , Alivisatos A. Paul 
Published: January 2017

AbstractSpherical and cubic Pt nanoparticles and spherical, cubic and disk-shaped Co nanocrystals are produced by reduction of Pt2+-ion and decomposition of organometallic reagents in a hot solvent in presence of the surfactant molecules respectively. This displays the ability to control crystal growth and produce a range of nanoparticle shapes in the case of two different metallic elements.
First-Principles Studies of the Magnetic Properties of hcp Cr in Cr/Cu(111) and Cr/Ru(0001) Superlattices
Authors: Guo G. Y. 
Published: January 2017

AbstractLatest first-principles density functional theoretical calculations using the generalized gradient approximation and highly accurate all-eleectron full-potential linearized augmented plane wave method, show that bulk hcp Cr would be a paramagnet and that no ferromagnetic state could be stabilized over a wide range of volume [1]. To understand the recent observation of the weakly ferromagnetic state of Cr in hcp Cr/Ru (0001) superlattices [2], the same theoretical calculations have been carried out for the hcp Cr3/Ru7 (0001) and hcp Cr3/fcc Cu6 (111) superlattices. The Cr/Ru superlattice is found to be ferromagnetic with a small magnetic moment of ∼0.31μB/Cr while in contrast, Cr/Cu superlattice is found to be nonmagnetic.
Pole Figure Analysis of Epitaxial Films of ZnO:2wt%Al Grown on Sapphire Substrates by RF Magnetron Sputtering
Authors: Kuppusami P. , Fiechter S. , Ellmer K. 
Published: January 2017

AbstractAluminium-doped zinc oxide (ZnO:Al) films have been grown on c-plane (001) and a-plane (110) sapphire by RF magnetron sputtering from a ceramic target. The films grew epitaxially, even at room temperature. However, the crystalline quality depends both on the substrate temperature as well as on the sapphire orientation. The best films, proved by X-ray diffraction (rocking curves and pole figure measurements) were grown on (110)-oriented sapphire in the temperature range 473 to 773 K. The minimum rocking curve half width was about 0.75 °. By Rutherford backscattering analysis it could be shown, that the films exhibit a significant variation of the defect density over the film thickness. The highest density, as expected, is observed at the interface sapphire/ZnO:Al. Films grown on (001)-oriented sapphire have higher rocking curve half widths (about 1.3 °) and exhibit sometimes two types of domains in the same film twisted by 30 °.
Anomalous Grain Growth in Sputtered CoCrMn Thin Films
Authors: Song Hajung , Kwon Soon-Ju , Shin Kyung-Ho 
Published: January 2017

AbstractThis paper presents anomalous grain growth in sputtered hcp CoCrMn thin films: The grain size is about 250 nm wide and a few micrometers long in the film of only 50 nm thickness. Both selected area diffraction (SAD) and x-ray texture analysis indicate that the perpendicular direction to the substrate is parallel to the zone axis of hcp<100> and hcp<110>. SAD also indicates that short axis of elongated grains is the c-axis of hcp structure, i.e. grains are elongated in the orthogonal direction to the c-axis. In addition, these elongated grains compose a grain bunch, in which grains are parallel to each other. Phi (φ) scan at grazing incidence x-ray diffraction (GID) geometry reveals that bunches are, as a whole, randomly oriented. However, neighboring bunches are misoriented about 10-20 degrees with each other, which is consistent with TEM observation. Such an anomalous grain growth of CoCrMn thin film is explained in views of mechanisms of nucleation and surface energy minimization.
Model Relating Thin Film Pzt Crystallographic Texture to Ferroelectric Switching Performance
Authors: FOX G.R. , Summerfelt S. 
Published: January 2017

AbstractThe fundamental physical property used for data storage in a ferroelectric non-volatile memory (FRAM) is the remanent polarization of a ferroelectric capacitor. In order to sense the data state of the capacitor, the charge pulse generated by either a switching or non-switching ferroelectric polarization is detected. Since the polarization of the ferroelectric is a vector property, the switchable polarization response of a ferroelectric capacitor is necessarily dependent on the texture of the ferroelectric material used to make the capacitor. A series of Ca, Sr, and La doped PbZr0.4Ti0.6O3 (PZT) capacitor test samples were produced with texture ranging from nearly complete {111} texture to random orientation. The volume fraction of the textured material was quantified by X-ray diffraction. An experimental correlation between texture and the switchable polarization was established using pulse switching measurements. A mathematical model was developed to explain the dependence of the switchable polarization on the crystallographic texture. It was found that the dependence of the saturated switchable polarization on texture required that there was no 90° domain reorientation. The impact of these findings will be related to the performance of FRAM.
Structure and Morphology of Reactively Sputtered In0.9Sn0.1Ox Layers
Authors: Mientus R. , Sieber I. , Ellmer K. 
Published: January 2017

AbstractIn this work, the influence of the discharge parameter oxygen partial pressure during reactive magnetron sputtering on the structure and morphology of In0.9Sn0.1Ox films is investigated. The oxygen partial pressure was varied in order to deposit In0.9Sn0.1Ox films with 0 ≤ x ≤ 1.76. The composition x was measured by Rutherford backscattering (RBS). For low x values, these films are metallic and opaque, while at x ≈ 1.5 the layers exhibit good properties as transparent and conducting electrodes. Further increase in x leads to transparent insulating films. The morphology of the films, investigated by SEM, shows significant variations with the composition x. While the metallic films consist of coarse globular grains, made up of polycrystalline indium-tin, a small addition of oxygen leads to nearly amorphous metal-oxide mixtures with smooth surfaces. Around x ≈ 1.5 the films are polycrystalline with the cubic In2O3 bixbyite structure and show a resistivity minimum. The cross sectional morphology of these films exhibits a columnar structure of broad bundles (≈250 nm), composed of narrow needle-like crystallites of about 20 nm diameter. At very high oxygen partial pressures, the grain size decreases while the strain and the resistivity increase significantly.
Management of Neonatal Hypotension
Authors: Kalish Brian T. , McPherson Christopher 
Published: January 2017

AbstractHypotension is a common problem in neonates with complex underlying pathophysiology. Although treatment of low blood pressure is common, clinicians must use all available information to target neonates with compromised perfusion. Pharmacotherapy should be tailored to the specific physiologic perturbations of the individual neonate. Dopamine is the most commonly utilized agent and may be the most appropriate agent for septic shock with low diastolic blood pressure. However, alternative therapies should be considered for other etiologies of hypotension, including milrinone and vasopressin for persistent pulmonary hypertension of the newborn and dobutamine for patent ductus arteriosus. Additional studies are required to refine the approach to neonatal hypotension and document the long-term outcomes of treated neonates.
Pemetaan Habitat Ruaya Benih Ikan Sidat (Anguilla bicolor) dan Potensinya di Pantai Selatan Jawa
Authors: Haryono Haryono , Wahyudewantoro Gema 
Published: January 2017

The eels is fish commodities that interesting and prospective for cultured. For the fish fry supply stillrely on catches of wild nature, one of them the south coast of Java. But the these habitat andabundance not yet to mapping The aims of this study to assess the conditions migration habitat ofglass eel, abundance, identification of threats, and conservation efforts. The study used surveymethods, glass eel catched with hand nets size 1 x 1 m, catching at night each 2 hours, thenumber of fisherman are three peoples. The results of the study recorded nine rivers and four ofthem potential as migration habitat of eels, habitat conditions are still good, the highest abundanceis Cibuniangen river in the rainy season, the daily abundance was fluctuated and the highest at3:00 a.m, identified several threats, conservation need integrated effort.Keywords: eels, habitat, abundance, conservation
Aspek Biologi Ikan Layang (Decapterus russelli) di Perairan Latuhalat, Kecamatan Nusaniwe, Pulau Ambon
Authors: Ongkers Ong T.S , Pattikawa Jesaja A , Rijoly Frederick 
Published: January 2017

This research was carried out in the waters of Latulahalat, Ambon Island from June to August 2016. The objectives of the research were to study some biological aspects namely sex ratio, gonad maturity level, size distribution and growth pattern of scad mackerel, Decaterus russelli. Fish samples were collected every month at fish landing from purse seine fishers. Sex ratios of scad mackerel in the area were equal i.e. 1:1 with the male dominated gonad maturity levels I and IV while female dominated gonad maturity levels II, III and V. In general, male fishes were smaller than female ones in term of length and weight. Scad mackerel in the area showed positive allometric growth except for male on August which showed isometric growth Keywords: Decaterus russelli, sex ratio, .gonad maturity level, growth pattern
Chemical EOR for Heavy Oil: The Canadian Experience
Authors: Wilson Adam 
Published: January 2017

This article, written by Special Publications Editor Adam Wilson, contains highlights of paper SPE 169715, “Chemical EOR for Heavy Oil: The Canadian Experience,” by Eric Delamaide, SPE, IFP Technologies; Brigitte Bazin and David Rousseau, IFP Energies nouvelles; and Guillaume Degre, Solvay, prepared for the 2014 SPE EOR Conference at Oil and Gas West Asia, Muscat, Oman, 31 March–2 April. The paper has not been peer reviewed.
Chemical enhanced-oil-recovery (EOR) methods such as polymer and alkaline/surfactant/polymer (ASP) flooding are generally not considered suitable for oil viscosities greater than 100 or 200 cp. However, this perception is changing, in particular because of field results from a number of chemical EOR pilots or full-field floods conducted in Canada in higher viscosity oil. The aim of this paper is to review some of these projects.
Introduction
Canada is well-known for its heavy-oil and bitumen reserves. Most of the bitumen reserves are exploited using thermal methods, such as cyclic steam stimulation or steam-assisted gravity drainage, while heavy oil is exploited mostly using cold production methods, such as cold heavy-oil production with sand. Cold production leads to recovery of less than 10% of original oil in place (OOIP). Thermal methods are not always applicable, in particular when the pay is thin. In that case, alternatives such as chemical EOR are required to increase recovery. The two main chemical EOR processes are polymer and ASP flooding.
In the past 10 years, several chemical-flooding projects have taken place in Canadian heavy-oil fields. The most successful of these is the Pelican Lake project, which is currently producing more than 60,000 B/D, much of it through polymer flooding. But other less-well-known projects such as the Taber South project, the Mooney project, and the Seal project are all interesting and worthy of discussion. For full descriptions of these fields, please see the complete paper.
Projects
Pelican Lake Polymer Flood. The Pelican Lake field is approximately 250 km north of Edmonton, Alberta, Canada (Fig. 1). The recovery factor for primary production remained low even after the introduction of horizontal drilling. Thus, a first—unsuccessful—polymer flood was attempted in 1997, after which waterflood was also piloted. The waterflood managed to increase oil production but with high water cut. Thus, another polymer pilot was started in 2005.
Polymer injection started in May 2005. The responses were excellent, with rates going from 18 to 232 BOPD in the first well, from 9 to 364 BOPD in the central well, and from 16 to 139 BOPD in the last well. The water cut increased slowly and moderately in all three wells. The operators estimate that polymer flooding will increase the recovery factor to 20 to 30% of OOIP.
Technology Focus: Natural Gas Processing and Handling (April 2016)
Authors: Wang Xiuli 
Published: January 2017

Technology Focus
Despite the currently deteriorating oil and gas prices (at the time of writing, West Texas intermediate crude was at USD 32.38/bbl and Henry Hub natural gas was at USD 2.25/million Btu), natural gas, the “least carbon-intensive” fossil fuel, is still projected by Exxon- Mobil, the International Energy Agency, and other sources to grow by 65% from 2010 to 2040, with the majority of the increasing demand coming from the Asia Pacific region.
According to the BP Statistical Review of World Energy, in 2014, total world natural-gas production was 3460.6 billion m3 and 43.2% of it was from the United States (728.3 billion m3, 21.4%), the Russian Federation (578.7 billion m3, 16.7%), and Qatar (177.2 billion m3, 5.1%). On the consumption side, the total global natural-gas consumption was 3393 billion m3 and accounted for 23.7% of the total world energy makeup. The top three leading consumers were the US (759.4 billion m3, 22.7%), the Russian Federation (409.2 billion m3, 12%), and China (185.5 billion m3, 5.4%), and they consumed 40.1% of the total world natural gas.
Considering the current oil and gas market conditions and that processing and handling are part of the natural-gas supply chain, ensuring that gas processing and handling are cost efficient and safe becomes even more imperative.
Currently, total gas trades were 997.2 billion m3 (in 2014), slightly less than in 2013 (1032.8 billion m3). Pipelines and liquefied natural gas (LNG) remain the primary gas-transportation means, with shares of 66.6 and 33.4% in 2014, respectively.
While pipelines remain the traditional means of transportation, LNG technology provides an effective alternative for long distances and offshore environments. The design philosophy has gone from simple to sophisticated to more sophisticated, without compromising safety and operability.
The advancements of LNG technologies enable the operators to operate their plants with lower specific-energy consumption, shorter downtime, safer environments, and generally higher profits.
The following papers and additional readings focus on LNG front-end design, safety topics associated with natural-gas transportation through LNG and pipelines, new improvements around the well-known Fischer-Tropsch process for enhanced gas-to-diesel conversion, flare-gas management, and carbon-adsorbed natural gas as an option for automotive fuel.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 177861 Challenges and Complexity of World’s Largest Flares-Reduction Project by Christopher Howell, Basrah Gas Company, et al.
OTC 26020 Terminal and Transportation Risk Assessment for LNG Export in North America by H. Hamedifar, DNV GL, et al.
SPE 176129 Storage of Natural Gas by Adsorption Process by Anshul Arora, American International Group, et al.