bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving pancreas graft utilization through importation
Authors: Torabi Julia , Rocca Juan P. , Choinski Krystina , Lorenzen Katherine , Yongue Camille , Lubetzsky Michelle L. , Herbert Melvon E. , Chokechanachaisakul Attasit , Ajaimy Maria , Kamal Layla , Akalin Enver , Kinkhabwala Milan , Graham Jay A. 
Published: November 2017

AbstractBackgroundWe analyze our outcomes utilizing imported allografts as a strategy to shorten wait list time for pancreas transplantation.MethodsThis is an observational retrospective cohort of 26 recipients who received either a locally procured (n = 16) or an imported pancreas graft (n = 10) at our center between January 2014 and May 2017. Wait list times of this cohort were compared to UNOS Region 9 (New York State and Western Vermont). Hospital financial data were also reviewed to analyze the cost‐effectiveness of this strategy.ResultsImported pancreas grafts had significantly increased cold ischemia times (CIT) and peak lipase (PL) levels compared to locally procured grafts (CIT 827 vs 497 minutes; P = .001, PL 563 vs 157 u/L; P = .023, respectively). There were no differences in graft or patient survival. The median wait time was significantly lower for simultaneous kidney‐pancreas transplants at our center (518 days, n = 21) compared to Region 9 (1001 days, n = 65) P = .038. Despite financial concerns, the cost of transport for imported grafts was offset by lower standard acquisition costs.ConclusionsImported pancreas grafts may be a cost‐effective strategy to increase organ utilization and shorten wait times in regions with longer waiting times.
A phase Ib, open‐label, single arm study to assess the safety, pharmacokinetics, and impact on humoral sensitization of SANGUINATE infusion in patients with end‐stage renal disease
Authors: Abu Jawdeh Bassam G. , Woodle Ervin Steve , Leino Abbie D. , Brailey Paul , Tremblay Simon , Dorst Tonya , Abdallah Mouhamad H. , Govil Amit , Byczkowski Daniel , Misra Hemant , Abuchowski Abraham , Alloway Rita R. 
Published: November 2017

AbstractThe endeavor to study desensitization in kidney transplantation has not been matched by an effort to investigate strategies to prevent sensitization. In this study (NCT02437422), we investigated the safety, impact on sensitization, and pharmacokinetics of SANGUINATE (SG), a hemoglobin‐based oxygen carrier, as a potential alternative to packed red blood cells (PRBC) in transplant candidates with end‐stage renal disease (ESRD). Ten ESRD subjects meeting inclusion/exclusion (I/E) criteria were planned to receive three weekly infusions of SG (320 mg/kg). The study was stopped after five subjects were enrolled, and their data were analyzed after completing a follow‐up period of 90 days. Two subjects had elevated troponin I levels in setting of SG infusion, one of which was interpreted as a non‐ST elevation myocardial infarction. All other adverse events were transient. SG pharmacokinetic analysis showed mean (SD) Cmax, Tmax, AUC, and half‐life of 4.39 (0.69) mg/mL, 2.42 (0.91) hours, 171.86 (52.35) mg h/mL, and 40.60 (11.96) hours, respectively. None of the subjects developed new anti‐HLA antibodies following SG infusion and throughout the study period. In conclusion, SG is a potential alternative to PRBCs in ESRD patients considered for kidney transplantation as it was not associated with humoral sensitization. Larger studies in highly sensitized patients are required to further evaluate for potential safety signals.
Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS
Authors: Fujiwara Tomonori , Kofuji Takefumi , Mishima Tatsuya , Akagawa Kimio 
Published: November 2017

AbstractIn neuronal plasma membrane, two syntaxin isoforms, HPC‐1/syntaxin 1A (STX1A) and syntaxin 1B (STX1B), are predominantly expressed as soluble N‐ethylmaleimide‐sensitive fusion attachment protein receptors, also known as t‐SNAREs. We previously reported that glutamatergic and GABAergic synaptic transmissions are impaired in Stx1b null mutant (Stx1b−/−) mice but are almost normal in Stx1a null mutant (Stx1a−/−) mice. These observations suggested that STX1A and STX1B have distinct functions in fast synaptic transmission in the central nervous system (CNS). Interestingly, recent studies indicated that Stx1a−/− or Stx1a+/− mice exhibit disruption in the monoaminergic system in the CNS, causing unusual behaviour that is similar to neuropsychological alterations observed in psychiatric patients. Here, we studied whether STX1B contributes to the regulation of monoaminergic system and if STX1B is related to neuropsychological properties in human neuropsychological disorders similar to STX1A. We found that monoamine release in vitro was normal in Stx1b+/− mice unlike Stx1a−/− or Stx1a+/− mice, but the basal extracellular dopamine (DA) concentration in the ventral striatum was increased. DA secretion in the ventral striatum is regulated by GABAergic neurons, and Stx1b+/− mice exhibited reduced GABA release both in vitro and in vivo, disrupting the DAergic system in the CNS of these mice. We also found that Stx1b+/− mice exhibited reduced pre‐pulse inhibition (PPI), which is believed to represent one of the prominent schizotypal behavioural profiles of human psychiatric patients. The reduction in PPI was rescued by DA receptor antagonists. These observations indicated that STX1B contributes to excess activity of the DAergic system through regulation of GABAergic transmission.
Vegetation cover—another dominant factor in determining global water resources in forested regions
Authors: Wei Xiaohua , Li Qiang , Zhang Mingfang , Giles‐Hansen Krysta , Liu Wenfei , Fan Houbao , Wang Yi , Zhou Guoyi , Piao Shilong , Liu Shirong 
Published: November 2017

AbstractForested catchments provide critically important water resources. Due to dramatic global forest change over the past decades, the importance of including forest or vegetation change in the assessment of water resources under climate change has been highly recognized by Intergovernmental Panel on Climate Change (IPCC); however, this importance has not yet been examined quantitatively across the globe. Here, we used four remote sensing‐based indices to represent changes in vegetation cover in forest‐dominated regions, and then applied them to widely used models: the Fuh model and the Choudhury‐Yang model to assess relative contributions of vegetation and climate change to annual runoff variations from 2000 to 2011 in forested landscape (forest coverage >30%) across the globe. Our simulations show that the global average variation in annual runoff due to change in vegetation cover is 30.7% ± 22.5% with the rest attributed to climate change. Large annual runoff variation in response to vegetation change is found in tropical and boreal forests due to greater forest losses. Our simulations also demonstrate both offsetting and additive effects of vegetation cover and climate in determining water resource change. We conclude that vegetation cover change must be included in any global models for assessing global water resource change under climate change in forest‐dominant areas.
Factors associated with home hazards: Findings from the Malaysian Elders Longitudinal Research study
Authors: Romli Muhammad H , Tan Maw P , Mackenzie Lynette , Lovarini Meryl , Kamaruzzaman Shahrul B , Clemson Lindy 
Published: November 2017

AimPrevious studies have investigated home hazards as a risk factor for falls without considering factors associated with the presence of home hazards. The present study aimed to determine patterns of home hazards among urban community‐dwelling older Malaysians, and to identify factors contributing to home hazards.MethodsCross‐sectional data from the initial wave of the Malaysian Elders Longitudinal Research study were used. Basic demographics were obtained from the Global Questionnaire. Basic and instrumental activities of daily living were measured using the Katz and Lawton–Brody scales, and home hazards were identified using the Home Falls and Accidents Screening Tool. Participants were also asked if they had fallen in the previous 12 months.ResultsData were analyzed from 1489 participants. Hazards were frequently identified (>30%) in the toilet and bathroom areas (no grab rail, no non‐slip mat, distant toilet), slippery floors, no bedside light access and inappropriate footwear. Lower educational attainment, traditional housing, Chinese ethnicity, greater number of home occupants, lower monthly expenditure, poor vision and younger age were the factors independently associated with home hazards.ConclusionsThis study provides evidence that home hazards are a product of the interaction of the individual's function within their home environment. Hazards are also influenced by local sociocultural and environmental factors. The relationship between home hazards and falls appears complex and deserves further evaluation. Geriatr Gerontol Int 2018; 18: 387–395.
Survival prediction among nursing home residents: A longitudinal study
Authors: Lai Claudia Kam Yuk , Ho Lily Yuen Wah , Chin Kenny Chi Wing , Kwong Enid Wai Yung 
Published: November 2017

AimTo determine the survival time and predictors of survival of residents in a nursing home.MethodsNursing home residents admitted from June 2008 (when the nursing home started operating) to December 2012 (n = 230) to a new nursing home in Hong Kong were prospectively followed. The predictors of survival in the residents were assessed annually, with the exception of those who did not want to continue with the study, or were hospitalized, discharged from the nursing home or died, to compare changes occurring from 2008 to 2012. Cox's regression analysis was used to examine the predictors of survival.ResultsA total of 66 of the nursing home residents (28.7%) died during the study period. The median length of survival was 20.46 months. Sex, the number of diseases, depressive symptoms, cognitive status and nutritional status were found to be significant predictors of survival.ConclusionsIt is crucial for healthcare providers to offer quality care to residents in long‐term care to enhance their well‐being in the final sojourn of their lives. Although there are no consistent reports of predictors in the international literature, it is important to address the modifiable predictors, as this might lead to improvements in the quality of life of the residents. Geriatr Gerontol Int 2018; 18: 428–433.
Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals
Authors: Luetragoon Thitiya , Rutqvist Lars E. , Tangvarasittichai Orathai , Andersson Bengt‐Åke , Löfgren Sture , Usuwanthim Kanchana , Lewin Nongnit L. 
Published: November 2017

SummaryCigarette smoke contains toxic and carcinogenic substances that contribute to the development of cancer and various diseases. Genetic variation might be important, because not all smokers develop smoking‐related disease. The current study addressed the possible interactions among selected single nucleotide polymorphisms (SNPs) in genes related to systemic inflammation, smoking status, the levels of circulating immune response cells and plasma biomarkers of systemic inflammation. Sixty‐four healthy blood donors were recruited, 31 of whom were current smokers and 33 were never‐users of tobacco products, references. Compared to references, the smokers showed significantly increased levels of circulating total white blood cells, lymphocytes, monocytes, neutrophils, basophils and C‐reactive protein (CRP). Smokers also more frequently exhibited circulating cell phenotypes that are associated with an immunocompromised state: CD8dim cells in the lymphocyte group, CD13+ CD11+, CD13+ CD14+, CD13+ CD56+ cells in the monocyte group and CD13+ CD11+, CD13+ CD56+ cells in the neutrophil group. We observed an interaction among SNPs, smoking status and some of the studied biomarkers. The average plasma CRP level was significantly higher among the smokers, with the highest level found among those with the CRP rs1800947 CC genotype. Additionally, an increased CD8+ GZB+ cells in the CD8dim group were found among smokers with the GZB rs8192917 AA genotype. Thus, smoking appears to be associated with systemic inflammation and increased levels of circulating immunosuppressive cells. The extent of these effects was associated with SNPs among the smokers. This observation may contribute to a better understanding of the genetic susceptibility of smoking‐related disease and the variations observed in clinical outcomes.
18. New Genera and Species of Ethiopian Tabanidæ, Subfamily Pangoniinæ (Diptera)
Authors: Austen E. E. 
Published: November 2017

SummaryIn the foregoing paper, two new genera and thirteen new species of Ethiopian Tabanidæ, subfamily Pangoniinæ, are described and figured: a list of these genera and species, showing the provenance of the type or typical series in each case, is appended.Bacloceras, gen. nov.turneri, sp. n. Natal.Sphecodemyia, gen. nov.lamborni, sp. n. Nyasaland Protectorate.secunda, sp. n.Hinea hiqvhris, sp. n. Rhodesia (Southern and Northern).bicolor, sp. n. Nyasaland Protectorate.Buplex albicinctus, sp. n. South Africa Cape Province).Phara tumidifacies, sp. n. ( ).nigripleuris, sp. n. ( ).bivirgulata, sp. n. Natal; Zululand.bracteata, sp. n. Nyasaland Protectorate; Southern Rhodesia.Silvius contrarius, sp. n. South Africa (Cape Province).pulchripennis, sp. n. Kenya Colony.Chrysops perpensa, sp. n. Nyasaland Protectorate.Both species of Sphecodemyia are remarkably wasp like in appearance; and, though unfortunately in neither case has it yet proved possible to identify the model, the strongly mimetic character of this new genus is as undeniable as the even more elaborate and astonishing resemblance between Melissomorpha indiana Ricardo, an Oriental Pangoniine discovered in Sikhim by the late Lt. Col. C. T. Bingham, and the worker of Apis dorsata Fabr.
Rent sharing to control noncartel supply in the German cement market
Authors: Harrington Joseph E. , Hüschelrath Kai , Laitenberger Ulrich 
Published: November 2017

AbstractA challenge for many cartels is avoiding a destabilizing increase in noncartel supply in response to having raised price. In the case of the German cement cartel that operated over 1991–2002, the primary source of noncartel supply was imports from Eastern European cement manufacturers. Testimonies in a private enforcement case have claimed that the cartel sought to control imports by sharing rents with intermediaries in order to discourage them from sourcing foreign supply. Specifically, cartel members would allow an intermediary to issue the invoice for a transaction and charge a fee even though the output went directly from the cartel member's plant to the customer. We investigate this claim by first developing a theory of collusive pricing that takes account of the option of bribing intermediaries. The theory predicts that the cement cartel members are more likely to share rents with an intermediary when the nearest Eastern European plant is closer and there is more Eastern European capacity outside of the control of the cartel. Estimating a logit model that predicts when a cartel member sells through an intermediary, the empirical analysis supports both predictions.
Improving ‐Omics‐Based Research and Precision Health in Minority Populations: Recommendations for Nurse Scientists
Authors: Taylor Jacquelyn Y. , Barcelona de Mendoza Veronica 
Published: November 2017

AbstractPurposeThe purpose of this article is to provide an overview of the role of nurse scientists in ‐omics‐based research and to promote discussion around the conduct of ‐omics‐based nursing research in minority communities. Nurses are advocates, educators, practitioners, scientists, and researchers, and are crucial to the design and successful implementation of ‐omics studies, particularly including minority communities. The contribution of nursing in this area of research is crucial to reducing health disparities.MethodsIn this article, challenges in the conduct of ‐omics‐based research in minority communities are discussed, and recommendations for improving diversity among nurse scientists, study participants, and utilization of training and continuing education programs in ‐omics are provided.Findings and ConclusionsMany opportunities exist for nurses to increase their knowledge in ‐omics and to continue to build the ranks of nurse scientists as leaders in ‐omics‐based research. In order to work successfully with communities of color, nurse scientists must advocate for participation in the Precision Medicine Initiative, improve representation of nurse faculty of color, and increase utilization of training programs in ‐omics and lead such initiatives.Clinical RelevanceAll nursing care has the potential to be affected by the era of ‐omics and precision health. By taking an inclusive approach to diversity in nursing and ‐omics research, nurses will be well placed to be leaders in reducing health disparities through research, practice, and education.
Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
Authors: Ballent M. , Viviani P. , Imperiale F. , Dominguez P. , Halwachs S. , Mahnke H. , Honscha W. , Lanusse C. , Virkel G. , Lifschitz A. 
Published: November 2017

Monepantel (MNP) is a novel anthelmintic compound launched into the veterinary pharmaceutical market. MNP is not licenced for use in dairy animals due to the prolonged elimination of its metabolite monepantel sulphone (MNPSO2) into milk. The goal of this study was to evaluate the presence of potential in vivo drug‐drug interactions affecting the pattern of milk excretion after the coadministration of the anthelmintics MNP and oxfendazole (OFZ) to lactating dairy cows. The concentrations of both parent drugs and their metabolites were measured in plasma and milk samples by HPLC. MNPSO2 was the main metabolite recovered from plasma and milk after oral administration of MNP. A high distribution of MNPSO2 into milk was observed. The milk‐to‐plasma ratio (M/P ratio) for this metabolite was equal to 6.75. Conversely, the M/P ratio of OFZ was 1.26. Plasma concentration profiles of MNP and MNPSO2 were not modified in the presence of OFZ. The pattern of MNPSO2 excretion into milk was also unchanged in animals receiving MNP plus OFZ. The percentage of the total administered dose recovered from milk was 0.09 ± 0.04% (MNP) and 2.79 ± 1.54% (MNPSO2) after the administration of MNP alone and 0.06 ± 0.04% (MNP) and 2.34 ± 1.38% (MNPSO2) after the combined treatment. The presence of MNP did not alter the plasma and milk disposition kinetics of OFZ. The concentrations of the metabolite fenbendazole sulphone tended to be slightly higher in the coadministered group. Although from a pharmacodynamic point of view the coadministration of MNP and OFZ may be a useful tool, the presence of OFZ did not modify the in vivo pharmacokinetic behaviour of MNP and therefore did not result in reduced milk concentrations of MNPSO2.
A retrotransposon in an HKT1 family sodium transporter causes variation of leaf Na+ exclusion and salt tolerance in maize
Authors: Zhang Ming , Cao Yibo , Wang Zhiping , Wang Zhi‐qiang , Shi Junpeng , Liang Xiaoyan , Song Weibin , Chen Qijun , Lai Jinsheng , Jiang Caifu 
Published: November 2017

Summary

Soil salinity is one of several major abiotic stresses that constrain maize productivity worldwide. An improved understanding of salt‐tolerance mechanisms will thus enhance the breeding of salt‐tolerant maize and boost productivity. Previous studies have indicated that the maintenance of leaf Na+ concentration is essential for maize salt tolerance, and the difference in leaf Na+ exclusion has previously been associated with variation in salt tolerance between maize varieties.

Here, we report the identification and functional characterization of a maize salt‐tolerance quantitative trait locus (QTL), Zea mays Na+ Content1 (ZmNC1), which encodes an HKT‐type transporter (designated as ZmHKT1).

We show that a natural ZmHKT1 loss‐of‐function allele containing a retrotransposon insertion confers increased accumulation of Na+ in leaves, and salt hypersensitivity. We next show that ZmHKT1 encodes a plasma membrane‐localized Na+‐selective transporter, and is preferentially expressed in root stele (including the parenchyma cells surrounding the xylem vessels). We also show that loss of ZmHKT1 function increases xylem sap Na+ concentration and causes increased root‐to‐shoot Na+ delivery, indicating that ZmHKT1 promotes leaf Na+ exclusion and salt tolerance by withdrawing Na+ from the xylem sap.

We conclude that ZmHKT1 is a major salt‐tolerance QTL and identifies an important new gene target in breeding for improved maize salt tolerance.
Combined transcriptome and translatome analyses reveal a role for tryptophan‐dependent auxin biosynthesis in the control of DOG1‐dependent seed dormancy
Authors: Bai Bing , Novák Ondřej , Ljung Karin , Hanson Johannes , Bentsink Leónie 
Published: November 2017

Summary

The importance of translational regulation during Arabidopsis seed germination has been shown previously. Here the role of transcriptional and translational regulation during seed imbibition of the very dormant DELAY OF GERMINATION 1 (DOG1) near‐isogenic line was investigated.

Polysome profiling was performed on dormant and after‐ripened seeds imbibed for 6 and 24 h in water and in the transcription inhibitor cordycepin. Transcriptome and translatome changes were investigated.

Ribosomal profiles of after‐ripened seeds imbibed in cordycepin mimic those of dormant seeds. The polysome occupancy of mRNA species is not affected by germination inhibition, either as a result of seed dormancy or as a result of cordycepin treatment, indicating the importance of the regulation of transcript abundance.

The expression of auxin metabolism genes is discriminative during the imbibition of after‐ripened and dormant seeds, which is confirmed by altered concentrations of indole‐3‐acetic acid conjugates and precursors.
Folate status in women of reproductive age as basis of neural tube defect risk assessment
Authors: Bailey Lynn B. , Hausman Dorothy B. 
Published: November 2017

AbstractReliable folate status data for women of reproductive age (WRA) to assess global risk for neural tube defects (NTDs) are needed. We focus on a recent recommendation by the World Health Organization that a specific “optimal” red blood cell (RBC) folate concentration be used as the sole indicator of NTD risk within a population and discuss how to best apply this guidance to reach the goal of assessing NTD risk globally. We also emphasize the importance of using the microbiologic assay (MBA) as the most reliable assay for obtaining comparable results for RBC folate concentration across time and countries, the need for harmonization of the MBA through use of consistent key reagents and procedures within laboratories, and the requirement to apply assay‐matched cutoffs for folate deficiency and insufficiency. To estimate NTD risk globally, the ideal scenario would be to have country‐specific population‐based surveys of RBC folate in WRA determined utilizing a harmonized MBA, as was done in recent studies in Guatemala and Belize. We conclude with guidance on next steps to best navigate the road map toward the goal of generating reliable folate status data on which to assess NTD risk in WRA in low‐ and middle‐income countries.