bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the effect of prescribed burning in temperate and boreal forest on biodiversity, beyond tree regeneration, pyrophilous and saproxylic species? A systematic review protocol
Authors: Eales Jacqualyn , Haddaway Neal R. , Bernes Claes , Cooke Steven J. , Jonsson Bengt Gunnar , Kouki Jari , Petrokofsky Gill 
Published: November 2016

Abstract
Background
Forests set aside from productive forestry are often considered best conserved by non-intervention. However, biodiversity is often maintained in natural forests by a background level of disturbance, which, in some forests, takes the form of forest fires. Set-aside forests may therefore benefit from continuation of such disturbances, which, in forests under protection, must be managed anthropogenically. While the effects of prescribed burning on tree regeneration and on pyrophilous and/or saproxylic species in some regions are well known, effects on other organisms are less clear and/or consistent. It would be valuable to broaden the knowledge of how prescribed burning affects forest biodiversity, particularly because this practice is increasingly considered as a conservation management intervention. The primary aim of the proposed systematic review is to clarify how biodiversity is affected by prescribed burning in temperate and boreal forests. The ultimate purpose of the review is to investigate whether and how such prescribed burning may be useful as a means of conserving or restoring biodiversity, beyond that of pyrophilous and saproxylic species, in forest set-asides.

Methods
The review will examine primary field studies of how prescribed burning affects biodiversity in boreal and temperate forests. We will consider studies made in such forests anywhere in the world, and will include forests both in protected areas and under commercial management. Non-intervention will be used as a comparator. Relevant outcomes will include a range of measures of biodiversity, including abundance and diversity, but not of pyrophilous and saproxylic species. Relevant studies will be taken from a recent systematic map of the evidence on biodiversity impacts of active management in forests set aside for conservation or restoration. Additional searches and a search update will be undertaken in a subset of databases from the systematic map, using a search string targeted to identify studies focused on prescribed burning interventions. Searches for additional literature will be made in the bibliographies of existing reviews of forest burning. Traditional academic literature and grey literature in English, French, Swedish and Finnish will be considered. Stakeholders who engage in prescribed burning will be asked to provide relevant grey literature.
One-and-a-half nostril endoscopic transsphenoidal approach for pituitary adenomas—a technical report
Authors: Wen Guodao , Tang Chao , Zhong Chunyu , Li Junyang , Cong Zixiang , Zhou Yuan , Liu Kaidong , Zhang Yong , Tohti Mamatemin , Ma Chiyuan 
Published: November 2016

Background Binostril endoscopic transsphenoidal approach (BETA) provides sufficient manipulation space and wide endoscopic vision, although it increases the trauma of nose. Mononostril endoscopic transsphenoidal approach (META) has minimal trauma of nose, at the expense of space within the operation. We describe a one-and-a-half nostril endoscopic transsphenoidal approach (OETA) that combines the advantages of BETA and META. Methods We introduced OETA for pituitary adenomas with a detailed technical description. A retrospective analysis was also performed on 57 consecutive patients who underwent one-and-a-half nostril endoscopic transsphenoidal surgery between March 2014 and June 2015 at Jinling hospital. Results The gross total resection rate was 79%. The gross complete resection rate of Knosp grade 3 tumors were 63.6, and 27.3% in grade 4 tumors. Postoperative hormone remission was achieved in 14 out of 18 (77.8%) patients with secreting adenomas. Postoperative abnormal visual function improvement was achieved in 23 out of 32 patients (73%) with preoperative visual dysfunction. The overall intra-operative CSF leak was 17.5%, with the postoperative CSF leak decreased to 3.5% after the sellar reconstruction with the unilateral “rescue” nasoseptal flap procedure. The main sinonasal complaints 2 weeks after surgery were: loss of sense of smell (28%), decrease in sense of taste (4%), trouble breathing during the day (18%), thick nasal discharge (36%), post nasal discharge (8%), dried nasal material (6%), and headache (6%). Three months after surgery, there were no reports of decrease of taste, post nasal discharge, or dried nasal material. Other complaints were decreased significantly. Six months after surgery, the main complaints of sinonasal quality of life were negligible, and overall health status was near complete recovery to preoperative status. Conclusions The one-and-a-half nostril endoscopic transsphenoidal approach for pituitary adenomas is a simple and reliable technique. It provides not only a sufficient surgical corridor for a 2-surgeon/4 or 3-hands technique, but also ensures minimal invasion of the nasal canal.
SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5′UTR RNA
Authors: Han Yang , Wang Lvyin , Cui Jin , Song Yu , Luo Zhen , Chen Junbo , Xiong Ying , Zhang Qi , Liu Fang , Ho Wenzhe , Liu Yingle , Wu Kailang , Wu Jianguo 
Published: November 2016

ABSTRACT
Enterovirus 71 (EV71) possesses a single-stranded positive RNA genome that contains a single open reading frame (ORF) flanked by a 5′ untranslated region (5′UTR) and a polyadenylated 3′UTR. Here, we demonstrated that EV71 activates the production of silent mating type information regulation 2 homolog 1 (SIRT1), a histone deacetylase (HDAC). EV71 further stimulates SIRT1 sumoylation and deacetylase activity, and enhances SIRT1 translocation from the nucleus to the cytoplasm. More interestingly, activated SIRT1 subsequently binds with the EV71 3Dpol protein (a viral RNA-dependent RNA polymerase, RdRp) to repress the acetylation and RdRp activity of 3Dpol, resulting in the attenuation of viral genome replication. Moreover, SIRT1 interacts with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral polymerase, and attenuates EV71 RNA transcription and translation by interfering with viral RNA. These results uncover a new function of SIRT1 and reveal a new mechanism underlying the regulation of EV71 replication.
A new Plasmodium vivax reference sequence with improved assembly of the subtelomeres reveals an abundance of pir genes
Authors: Auburn Sarah , Böhme Ulrike , Steinbiss Sascha , Trimarsanto Hidayat , Hostetler Jessica , Sanders Mandy , Gao Qi , Nosten François , Newbold Chris I. , Berriman Matthew , Price Ric N. , Otto Thomas D. 
Published: November 2016

Plasmodium vivaxis now the predominant cause of malaria in the Asia-Pacific, South America and Horn of Africa. Laboratory studies of this species are constrained by the inability to maintain the parasite in continuousex vivoculture, but genomic approaches provide an alternative and complementary avenue to investigate the parasite’s biology and epidemiology. To date, molecular studies ofP. vivaxhave relied on the Salvador-I reference genome sequence, derived from a monkey-adapted strain from South America. However, the Salvador-I reference remains highly fragmented with over 2500 unassembled scaffolds. Using high-depth Illumina sequence data, we assembled and annotated a new reference sequence, PvP01, sourced directly from a patient from Papua Indonesia. Draft assemblies of isolates from China (PvC01) and Thailand (PvT01) were also prepared for comparative purposes. The quality of the PvP01 assembly is improved greatly over Salvador-I, with fragmentation reduced to 226 scaffolds. Detailed manual curation has ensured highly comprehensive annotation, with functions attributed to 58% core genes in PvP01 versus 38% in Salvador-I. The assemblies of PvP01, PvC01 and PvT01 are larger than that of Salvador-I (28-30 versus 27 Mb), owing to improved assembly of the subtelomeres. An extensive repertoire of over 1200Plasmodiuminterspersed repeat (pir) genes were identified in PvP01 compared to 346 in Salvador-I, suggesting a vital role in parasite survival or development. The manually curated PvP01 reference and PvC01 and PvT01 draft assemblies are important new resources to study vivax malaria. PvP01 is maintained at GeneDB and ongoing curation will ensure continual improvements in assembly and annotation quality.
RNF4 interacts with multiSUMOylated ETV4
Authors: Aguilar-Martinez Elisa , Guo Baoqiang , Sharrocks Andrew D. 
Published: November 2016

Protein SUMOylation represents an important regulatory event that changes the activities of numerous proteins. Recent evidence demonstrates that polySUMO chains can act as a trigger to direct the ubiquitin ligase RNF4 to substrates to cause their turnover through the ubiquitin pathway. RNF4 uses multiple SUMO interaction motifs (SIMs) to bind to these chains. However, in addition to polySUMO chains, a multimeric binding surface created by the simultaneous SUMOylation of multiple residues on a protein or complex could also provide a platform for the recruitment of multi-SIM proteins like RNF4. Here we demonstrate that multiSUMOylated ETV4 can bind to RNF4 and that a unique combination of SIMs is required for RNF4 to interact with this multiSUMOylated platform. Thus RNF4 can bind to proteins that are either polySUMOylated through a single site or multiSUMOylated on several sites and raises the possibility that such multiSIM-multiSUMO interactions might be more widespread.
Phylogenetic analysis of Indonesian gandaria (Bouea) using molecular markers of cpDNA trnL-F intergenic spacer
Authors: HARSONO TRI , PASARIBU NURSAHARA , SOBIR SOBIR , FITMAWATI FITMAWATI , PRASETYA EKO 
Published: November 2016

Abstract. Harsono T, Pasaribu N, Sobir, Fitmawati, Prasetya E.2017. Phylogenetic analysis of Indonesian gandaria (Bouea) using molecular markers of cpDNA trnL-F intergenic spacer. Biodiversitas 18: 51-57.Genus Bouea is a member of the Family Anacardiaceae which is widespread in Malesia region. Genus Bouea consists of two types, namely, B. oppositifolia (Roxb.) Adelb. and B. macrophylla Griffit. This study aims to uncover the genetic diversity of Bouea in Indonesia based on molecular markers of cpDNA trnL-F intergenic spacer. The samples of genetic material analyzed are 7 accessions of B. oppositifolia and 8 accessions of B. macrophylla coming from the collection of the Bogor Botanical Gardens and the field exploration activity in Sumatra, Java, Kalimantan and Ambon, and Anacardium occidentale and Mangifera indica are also used as an out-group comparator. Based on phylogenetic analysis using the maximum parsimony and neighbor-joining method, genus Bouea is a monophyletic group or is derived from the same ancestor. Bouea derived from Gunung Tua, North Sumatra, has the longest branch and showed up earlier than the other sample so it can be considered that the ancestor of genus Bouea. B. oppositifolia has branches longer and show up early so it can be considered the ancestor of B. macrophylla. Both types of genera Bouea grouped separately in the phylogenetic tree and supports grouping types in genera Bouea. The results of phylogenetic tree construction do not indicate a geographical grouping of accession. Based on the phylogenetic tree, genus Bouea has a closer relationship with Anacardium occidentale compared with Mangifera indica. The results showed that the markers cpDNA trnL-F intergenic spacer effectively used to determine relationship in genus Bouea.
Keywords: Bouea, cpDNA, gandaria, phylogenetic, trnL-F intergenic spacer
Estimating Mill Residue Surplus in Canada: A Spatial Forest Fiber Cascade Modeling Approach
Authors: Ghafghazi Saeed , Lochhead Kyle , Mathey Anne-Helen , Forsell Nicklas , Leduc Sylvain , Mabee Warren , Bull Gary 
Published: November 2016

Abstract
The potential development of a Canadian forest-based bioeconomy requires an assessment of both fiber availability and associated marginal supply costs. To a large extent, the bioeconomy is expected to rely on wood fiber made available through primary products, sawnwood, and pulp production processing streams. Therefore, it is important to understand the regional wood fiber flows and mill residue availability through various processing streams. In this study, we developed a spatially explicit Forest Fiber Cascade Model (FCM) to estimate regional fiber flows and availability of untapped residue surplus. The FCM was calibrated to 2013 production levels, and we evaluated the wood fiber cascade through existing forest industry in Canada. The results show that, under current conditions, there is limited availability of surplus mill residues in Canada, especially in the Eastern provinces. It is therefore critical to consider the impacts on regional fiber flows and feedstock availability to the secondary industries when designing feedstock supply strategies and policies for the emerging forest-based industries.
Cradle-to-Gate Life-Cycle Assessment of Laminated Veneer Lumber Production in the United States*
Authors: Bergman Richard D. , Alanya-Rosenbaum Sevda 
Published: November 2016

Abstract
To keep environmental product declarations current, the underlying life-cycle inventory (LCI) data and subsequent life-cycle assessment data for structural wood products must be updated. Primary data collected from the industry for the year 2012 were analyzed using the weighted-average to update LCIs for laminated veneer lumber (LVL) production on a 1-m3 basis in the Southeast (SE) and Pacific Northwest (PNW) regions of the United States. In addition, cradle-to-gate life-cycle impact assessments (LCIAs) were performed to assess the environmental impacts associated with LVL production for both regions. The cradle-to-gate LCIAs included three life-cycle stages: forestry operations, dry veneer production, and LVL production. The LCIs revealed that the dry veneer life-cycle stage dominated overall primary energy consumption for both the SE and the PNW at 6.83 (68.5%) and 6.75 GJ/m3 (75.3%), respectively. Energy consumption at the veneer stage was based primarily on renewable sources, especially wood fuel consumed on-site for thermal energy generation. In contrast, the LVL production stage was dependent mainly on fossil fuels, where the major resources consumed were natural gas and coal. The LCIA results showed that the veneer production stage dominated the majority of the five impact categories investigated with a greater than 50 percent contribution. Yet the LVL production stage had a significant contribution to the ozone depletion impact category, with 92 and 98 percent of total impact, for the SE and the PNW, respectively, coming from resin production used in LVL manufacturing. Overall, the contribution of forestry operations to the resulting impacts was minor.
Summer Houses, Ruin, Demolition and Rehabilitation , Modern Architecture heritage between 1950 and 1960 in Portugal
Authors: Freitas Tiago 
Published: November 2016

From the decades 1930/1940 in Portugal, begins the search for a new architectural model of holiday house derived from the chalet.From the late 1950s and according to Ana Tostões[1], begins a widespread acceptance of modern architecture by an elite bourgeoisie which will develop new resorts in Portugal.According to Rui Ramos [2] the urbanization along the beaches from Ofir in the North to Rodízio in the South, reveals this new way of modern living.These houses have resisted as built heritage from the decades of the 1940 till now. Some have not been able to avoid demolition; others are in a state of decay and abandoned ruin. It is urgent to avoid bad interventions that adulterate there main architectural characteristics or even the ruin and consequent demolishing in order of touristic investments of greater value.House Aiola was located in Arrábida, work of unquestionable modern taste, made use of prefabrication systems. The use of new materials, such as plywood and wood panels makes this house an authentic modern laboratory. The internal organization of the house in perfect communion with the outside is very fluid.According to Rui Ramos[3], the house reveals an unconditional adoption of modern, being able to innovate on the constraints imposed on it. The quality of this house and the uniqueness of his work transform this house one of the most radically modern examples built in Portugal, yet virtually unknown and demolished.The José Soares House in Ofir, of architects Cassiano Barbosa and Arménio Losa, was built in the year of 1950. This unknown work of the modern Portuguese architects is located in the summer resort of Ofir, where other important summer houses were built predominately between the decades of 1940 and 1970. This house experiments the new modern movement concepts as the use of ramps, new materials as fibre cement roofing or the clear distribution of sleeping and living areas in two blocks. At the same time it questions vernacular architecture by the use of apparent granite stone walls, the use of decorative tiles or wooden joinery. Nowadays the house is abandoned for decades and is coming to an advanced state of ruin.Modern Portuguese architecture has to be enlightened as of great value, so that owners and general public get aware of its heritage, before bigger mistakes are made.[1] TOSTÕES, Ana, “Casas de Férias modernas, anos 50 e estilo contemporâneo- A utopia de uma doce vida”, in Jornal de Arquitectos, Nº 196, Lisboa, 2000, Ordem dos Arquitectos, pp. 45-53.[2] RAMOS, Rui Jorge Garcia, A casa: arquitectura e projecto doméstico na primeira metade do século XX português, Porto, FAUP publicações, 2010.[3] Ibidem, pp.512.
Território, Património e Ideologia – Experiências pedagógicas no ensino de Projeto Final de Arquitetura do ISCTE-IUL
Authors: Pinto Paulo Tormenta 
Published: November 2016

Resumo:Este artigo foi realizado no na sequência do encontro da Rede PHI - Património Histórico e cultural Ibero-americano, ocorrido na Universidade de Coimbra, entre 17 e 21 de novembro de 2014. Nessa altura foram apresentadas experiências pedagógicas de várias escolas portuguesas em torno das temáticas do património. Da parte do ISCTE-IUL foram apresentados trabalhos realizados pelos estudantes de Projeto Final de Arquitetura do ano letivo 2012-2013, tendo como área de intervenção a Colina das Amoreiras em Lisboa. O exercício e a pesquisa realizada com os estudantes, permitiram ampliar a noção de património, através do cruzamento com o território e com as ações sobre este sedimentadas ao longo do tempo. AbstractThis article was done following the Red PHI – Historical and Cultural Ibero-american Heritage meeting, happened in Coimbra University between 17th and 21st of November 2014. At that time, Pedagogic experiences about heritage subjects were shared among several architectural Portuguese schools. From ISCTE-IUL were presented works developed by Final Architectural Project's students of the year 2012-2013 that had used Amoreiras Hill in Lisbon, as intervention area. The exercise and the research done with the students, allowed enlarging the heritage notion, crossing this theme with the territory and the sedimented actions above it, over time.
Robotergestütztes System für ein verbessertes neuromuskuläres Aufbautraining der Beinstrecker
Authors: Kolditz Melanie , Albin Thivaharan , Brüggemann Gert-Peter , Abel Dirk , Albracht Kirsten 
Published: November 2016

Zusammenfassung
Neuromuskuläres Aufbautraining der Beinstrecker ist ein wichtiger Bestandteil in der Rehabilitation und Prävention von
Muskel-Skelett-Erkrankungen. Effektives Training erfordert hohe Muskelkräfte, die gleichzeitig hohe Belastungen von
bereits geschädigten Strukturen bedeuten. Um trainingsinduzierte Schädigungen zu vermeiden, müssen diese Kräfte
kontrolliert werden. Mit heutigen Trainingsgeräten können diese Ziele allerdings nicht erreicht werden. Für ein sicheres
und effektives Training sollen durch den Einsatz der Robotik, Sensorik, eines Regelkreises sowie Muskel-Skelett-Modellen
Belastungen am Zielgewebe direkt berechnet und kontrolliert werden. Auf Basis zweier Vorstudien zu möglichen Stellgrößen
wird der Aufbau eines robotischen Systems vorgestellt, das sowohl für Forschungszwecke als auch zur Entwicklung neuartiger
Trainingsgeräte verwendet werden kann.
Blutgasregelung in low-flow-Anwendungen, speziell während normothermer ex-vivo Nierenperfusion
Authors: Gransow Marian , Kromnik Susanne , Tetschke Florian , Janssen Martin , Thiele Christine , Malberg Hagen 
Published: November 2016

Zusammenfassung
Normotherme ex-vivo Nierenperfusion ist eine vielversprechende Technik zur Erhaltung und Bewertung der Vitalität und
Viabilität von Organen. Die automatisierte Mehrgrößenregelung des Prozesses erhöht die Betriebssicherheit und erleichtert
die Bedienung. Für die beteiligte Regelung von arteriellem Sauerstoff- und Kohlendioxidpartialdruck sind in dieser Arbeit
zwei Regelungsstrategien anwendungsorientiert umgesetzt und in Simulationen, sowie im echten Prozess validiert worden. Die
Ergebnisse wurden im Kontext bekannter Regelungsstrategien diskutiert.
Quality control materials for pharmacogenomic testing in the clinic
Authors: Lin Guigao , Zhang Kuo , Han Yanxi , Li Jinming 
Published: November 2016

AbstractPharmacogenomics has significantly added to our understanding of drug responses in clinical pharmacology, changing the paradigm of treatment decisions. Interrogations of both inherited and somatic variations for therapeutic purposes are increasingly being adopted in clinics, where quality control (QC) materials are required. However, for many pharmacogenomic tests, the acquisition of well-characterized QC materials is often difficult or impossible. In this review, several sources of appropriate QC materials for therapy-associated genetic testing are discussed. Among them, the novel methods for producing renewable controls that resemble patient samples are highlighted. Owing to technological complexity, more efforts are needed to develop proper controls for next-generation sequencing-based assay.
Synthesis and characterization of thermosensitive and polarity-sensitive fluorescent PNIPAM-coated gold nanoparticles
Authors: Luo Chunhua , Qian Meijuan , Dong Qiujing 
Published: November 2016

Abstract
Thermosensitive PNIPAM-coated Au nanoparticles (AuNPs@P(NIPAM-co-MADMAC)) were synthesized by the radical “grafting through” copolymerization of 4-methacryloyloxy-4′-dimethylaminochalcone (MADMAC), MAEL-capped AuNPs and N-isopropylacrylamide (NIPAM) using azobisisobutyronitrile (AIBN) as the initiator. AuNPs@P(NIPAM-co-MADMAC) were characterized by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), 1H nuclear magnetic resonance (NMR), and Fourier transform infrared (FTIR) spectroscopy. AuNPs@P(NIPAM-co-MADMAC) exhibited thermo-sensitivity from poly(NIPAM-co-MADMAC) chains and sensitive fluorescence from the MADMAC group. AuNPs@P(NIPAM-co-MADMAC) showed weak fluorescence after the temperature increased from 25°C to 45°C, or after β-cyclodextrin (β-CD) was added. Furthermore, it exhibited strong fluorescence when the solvent was changed to ethanol or chloroform.