bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSReport: A New Computational Tool Designed for Automatic Analysis of Class Switch Recombination Junctions Sequenced by High-Throughput Sequencing
Authors: Boyer François , Boutouil Hend , Dalloul Iman , Dalloul Zeinab , Cook-Moreau Jeanne , Aldigier Jean-Claude , Carrion Claire , Herve Bastien , Scaon Erwan , Cogné Michel , Péron Sophie 
Published: April 2017

Abstract
B cells ensure humoral immune responses due to the production of Ag-specific memory B cells and Ab-secreting plasma cells. In secondary lymphoid organs, Ag-driven B cell activation induces terminal maturation and Ig isotype class switch (class switch recombination [CSR]). CSR creates a virtually unique IgH locus in every B cell clone by intrachromosomal recombination between two switch (S) regions upstream of each C region gene. Amount and structural features of CSR junctions reveal valuable information about the CSR mechanism, and analysis of CSR junctions is useful in basic and clinical research studies of B cell functions. To provide an automated tool able to analyze large data sets of CSR junction sequences produced by high-throughput sequencing (HTS), we designed CSReport, a software program dedicated to support analysis of CSR recombination junctions sequenced with a HTS-based protocol (Ion Torrent technology). CSReport was assessed using simulated data sets of CSR junctions and then used for analysis of Sμ-Sα and Sμ-Sγ1 junctions from CH12F3 cells and primary murine B cells, respectively. CSReport identifies junction segment breakpoints on reference sequences and junction structure (blunt-ended junctions or junctions with insertions or microhomology). Besides the ability to analyze unprecedentedly large libraries of junction sequences, CSReport will provide a unified framework for CSR junction studies. Our results show that CSReport is an accurate tool for analysis of sequences from our HTS-based protocol for CSR junctions, thereby facilitating and accelerating their study.
High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges
Authors: Langerak Anton W. , Brüggemann Monika , Davi Frédéric , Darzentas Nikos , van Dongen Jacques J. M. , Gonzalez David , Cazzaniga Gianni , Giudicelli Véronique , Lefranc Marie-Paule , Giraud Mathieu , Macintyre Elizabeth A. , Hummel Michael , Pott Christiane , Groenen Patricia J. T. A. , Stamatopoulos Kostas ,   the EuroClonality-NGS Consortium
Published: April 2017

AbstractAnalysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-throughput way have their limitations in terms of resolution, coverage, and biases. With the advent of high-throughput, next-generation sequencing (NGS) technologies, a deeper analysis of Ig and/or TCR (IG/TR) gene rearrangements is now within reach, which impacts on all main applications of IG/TR immunogenetic analysis. To bridge the generation gap from low- to high-throughput analysis, the EuroClonality-NGS Consortium has been formed, with the main objectives to develop, standardize, and validate the entire workflow of IG/TR NGS assays for 1) clonality assessment, 2) minimal residual disease detection, and 3) repertoire analysis. This concerns the preanalytical (sample preparation, target choice), analytical (amplification, NGS), and postanalytical (immunoinformatics) phases. Here we critically discuss pitfalls and challenges of IG/TR NGS methodology and its applications in hemato-oncology and immunology.
Serviço de Referência virtual via chat: uma análise comparativa de softwares para soluções de chat
Authors: Nakano Natalia , Jorente Maria José Vicentini , Padua Mariana Cantisani 
Published: April 2017

Introdução: Por volta de 2000, as TIC possibilitaram às bibliotecas universitárias a disponibilização do Serviço de Referência Virtual (SRV), um serviço mediado por software para a interação via chat entre o bibliotecário e os sujeitos em busca de informações de acervos ou de serviços das bibliotecas.Objetivo: O objetivo da pesquisa que fundamenta este artigo foi comparar os softwares utilizados por instituições diversas para disponibilizar o SRVMetodologia: As metodologias para a avaliação e construção teórica que subsidiaram este artigo consistiram-se da combinação de um aporte feito a partir da literatura produzida nacional e internacionalmente sobre o assunto, somado à pesquisa exploratória realizada em ambientes digitais para a análise do design dos software de chat, adicionadas à observação participante.Resultados: Os resultados apresentam e comparam os recursos e características dos softwares analisados.Conclusões: As conclusões deste estudo apontam para decisões contextuais das instituições e de seus profissionais da informação, de acordo com necessidades e perfis específicos dos sujeitos que interagem com a informação nos ambientes tradicionais e digito-virtuais delineados por parâmetros únicos em cada instituição.
Kalifaat en de islamitische staat
Authors: Berger Maurits 
Published: April 2017

Caliphate and Islamic State
Islamic scripture provides no definition of the caliphate and the term ‘Islamic state’ was coined for the first time in 1941. Pakistan and Iran call themselves an ‘Islamic republic,’ and ISIS has named itself an ‘Islamic State’ headed by a caliph. For many Muslims the term represents an ideal of a society that is just, peaceful and prosperous. That looks more like a utopian dream. So what is this Islamic state exactly? In this article we will answer that question by means of three approaches: the tenets of Islam, the historical and modern reality, and the wishes of the modern Muslims.
Concessie of confessie?
Authors: de Vries Jurn 
Published: April 2017

Concession or confession? Arguments of William of Orange and his environment for public tolerance
John Calvin had the view that church and state formed a spiritual unity. His followers accepted step by step the equal right for protestants and catholic in public society. Their arguments for this were mainly practical. Biblical arguments, as the parable of the tare in the field, played a minor role. Not earlier than in the 19th century public tolerance was a fundamental choice for neo-calvinists.
Zorgzame Kerk. Kerk zijn in de participatiesamenleving
Authors: Noordegraaf Herman 
Published: April 2017

A careful church. Being church in a participation society. Experiences with pilot projects from the Protestant Church in the Netherlands
In the context of the project Careful Church the Protestant Church in the Netherlands has developed pilot projects in the field of care and welfare in eighteen local churches. The aim of these is to get learning experiences to determine her position in local society. A description is given of these pilots and of the most important experiences. It is of relevance also on basis of contacts with organisations and local authorities to develop a plan of action. Most activities have to do with creating rooms for encounter and with assisting people who are dependent on care. In this way churches can be a relevant actor in local society with meaningful and small scale activities.
The quasi 2 day wave response in TIME‐GCM nudged with NOGAPS‐ALPHA
Authors: Wang Jack C. , Chang Loren C. , Yue Jia , Wang Wenbin , Siskind D. E. 
Published: April 2017

AbstractThe quasi 2 day wave (QTDW) is a traveling planetary wave that can be enhanced rapidly to large amplitudes in the mesosphere and lower thermosphere (MLT) region during the northern winter postsolstice period. In this study, we present five case studies of QTDW events during January and February 2005, 2006 and 2008–2010 by using the Thermosphere‐Ionosphere‐Mesosphere Electrodynamics‐General Circulation Model (TIME‐GCM) nudged with the Navy Operational Global Atmospheric Prediction System‐Advanced Level Physics High Altitude (NOGAPS‐ALPHA) Weather Forecast Model. With NOGAPS‐ALPHA introducing more realistic lower atmospheric forcing in TIME‐GCM, the QTDW events have successfully been reproduced in the TIME‐GCM. The nudged TIME‐GCM simulations show good agreement in zonal mean state with the NOGAPS‐ALPHA 6 h reanalysis data and the horizontal wind model below the mesopause; however, it has large discrepancies in the tropics above the mesopause. The zonal mean zonal wind in the mesosphere has sharp vertical gradients in the nudged TIME‐GCM. The results suggest that the parameterized gravity wave forcing may need to be retuned in the assimilative TIME‐GCM.
Method for improving the mechanical performance and thermal stability of unsaturated polyester resin/waste‐printed circuit board nonmetals composites via isocyanate chemistry
Authors: Hu Dechao , Jia Zhixin , Zhong Bangchao , Lin Jing , Liu Maolin , Luo Yuanfang , Jia Demin 
Published: April 2017

ABSTRACTTo strengthen the interfacial interactions between waste‐printed circuit board (WPCB) nonmetals and unsaturated polyester resin (UPE) and achieve a high performance in UPE composites, a novel type of polyurethane prepolymer (pre‐PU) with dual functions was prepared by the reaction of isophorone diisocyanate with poly(ethylene glycol). We found that pre‐PU was chemically bonded to the surface of the WPCB nonmetals, and a stronger interaction between the WPCB nonmetals and UPE matrix was formed. The mechanical properties and thermal stability of the UPE/pre‐PU–WPCB nonmetal composites showed remarkable improvements compared with those of the UPE/WPCB nonmetals composites, in particular, the impact toughness, which increased threefold. We envision that this promising modification method will not only open up new opportunities for the preparation of high‐performance plastic composites but also provide a guarantee for the practical industrial application of WPCB nonmetals. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45129.
Preparation and performance of a transparent poly(3,4‐ethylene dioxythiophene)–poly(p‐styrene sulfonate‐co‐acrylic acid sodium) film with a high stability and water resistance
Authors: Cai Wanping , Ma Xiangyan , Guo Jiahong , Peng Xing , Zhang Sai , Qiu Zhoutong , Ying Jie , Wang Jikui 
Published: April 2017

ABSTRACTPoly(p‐styrene sulfonate‐co‐acrylic acid sodium) (PSA) from the copolymerization of acrylic acid sodium and p‐styrene sulfonate monomers were used to dope poly(3,4‐ethylene dioxythiophene) (PEDOT) to generate PEDOT–PSA antistatic dispersions. Compared to those of the PEDOT–poly(p‐styrene sulfonate sodium) (PSS), the physical and electrical properties of the PEDOT–PSA conductive liquids were much better. The PEDOT–PSA films possessed a better water resistance without a decrease in the conductivity. The sheet resistance of the PEDOT–PSA–poly(ethylene terephthalate) (PET) films was about 1.5 × 104 Ω/sq with a 100 nm thickness, the same as the PEDOT–PSS–PET films. The transmittance of the PEDOT–PSA–PET films exceeded 88%. Furthermore, the environmental dispersity of the PEDOT–PSA antistatic dispersion was apparently improved by the dopant PSA so that the stability was extraordinarily promoted. Meanwhile, the water resistances of the PEDOT–PSA–PET and PEDOT–PSA films were also enhanced. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45163.
Graphene nanoribbons (GNRs) by unzipping MWCNTs for the improvement of PMMA microcellular foams
Authors: Li Meijuan , Cheng Ping , Luo Guoqiang , Shen Qiang , Zhang Lianmeng 
Published: April 2017

ABSTRACTThis work presents the cellular microstructures and properties of PMMA/graphene nanoribbons (GNRs) microcellular foams. GNRs were obtained by oxidative unzipping multiwalled carbon nanotubes and solvent thermal reduction in dimethylformamide (DMF), then they were mixed with PMMA to fabricate PMMA/GNRs nanocomposites by solution blending. Subsequently, supercritical carbon dioxide (scCO2) as a friendly foaming agent was applied to fabricate PMMA/GNRs microcellular foam by a batch foaming in a special mold. The morphology of cell structure was analyzed by scanning electron microscopy and image software, showing that the addition of a smaller content of GNRs caused a fine cellular structure with a higher cell density (∼3 × 1011 cells/cm3) and smaller cell sizes (∼1 μm) due to their remarkable heterogeneous nucleation effect. The mechanical testing of PMMA/GNRs microcellular foams demonstrated that the obtained GNRs also could be used as a reinforcing filler to increase the mechanical properties of PMMA foams. An improvement in the compressive strength of ∼80% (about 39% increase standardized by specific compressive strength) was achieved by 1.5 wt % GNRs addition, and the thermal stability of PMMA/GNRs foams was enhanced too. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45182.
Sichtbetonkosmetik
Authors: Kiltz Denis 
Published: April 2017

AbstractOptische Auffälligkeiten an Sichtbetonflächen lassen sich auch bei geeigneter Organisation einer Sichtbetonbaustelle und sorgfältiger Bauausführung nicht vollständig ausschließen. Mit einer fachgerechten und hochwertigen Sichtbetonkosmetik vom Fachbetrieb unter restauratorischen und künstlerischen Aspekten lassen sich optische Auffälligkeiten jedoch so beheben, dass die Nachbesserungen als solche nicht mehr erkennbar sind und sich das gewünschte Bild der Sichtbetonfläche einstellt. Im vorliegenden Beitrag werden die Techniken derartiger hochwertiger sichtbetonkosmetischer Maßnahmen sowie die zu beachtenden Grenzen vorgestellt. Zudem enthält der Beitrag Hinweise für Bauherrn, Planer und Ausführende, unter anderem zur Qualitätssicherung.
Systematic review of pressurized intraperitoneal aerosol chemotherapy for the treatment of advanced peritoneal carcinomatosis
Authors: Grass F , Vuagniaux A , Teixeira-Farinha H , Lehmann K , Demartines N , Hübner M 
Published: April 2017

Abstract

Background
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a minimally invasive approach under investigation as a novel treatment for patients with peritoneal carcinomatosis of various origins. The aim was to review the available evidence on mechanisms, clinical effects and risks.

Methods
This was a systematic review of the literature on pressurized intraperitoneal chemotherapy published between January 2000 and October 2016. All types of scientific report were included.

Results
Twenty-nine relevant papers were identified; 16 were preclinical studies and 13 were clinical reports. The overall quality of the clinical studies was modest; five studies were prospective and there was no randomized trial. Preclinical data suggested better distribution and higher tissue concentrations of chemotherapy agents in PIPAC compared with conventional intraperitoneal chemotherapy by lavage. Regarding technical feasibility, laparoscopic access and repeatability rates were 83–100 and 38–82 per cent. Surgery-related complications occurred in up to 12 per cent. Postoperative morbidity was low (Common Terminology Criteria for Adverse Events grade 3–5 events reported in 0–37 per cent), and hospital stay was about 3 days. No negative impact on quality of life was reported. Histological response rates for therapy-resistant carcinomatosis of ovarian, colorectal and gastric origin were 62–88, 71–86 and 70–100 per cent respectively.

Conclusion
PIPAC is feasible, safe and well tolerated. Preliminary good response rates call for prospective analysis of oncological efficacy.
Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography
Authors: Rossi S H , Hsu R , Blick C , Goh V , Nathan P , Nicol D , Fleming S , Sweeting M , Wilson E C F , Stewart G D 
Published: April 2017

Abstract

Background
The potential for an ultrasound-based screening programme for renal cell carcinoma (RCC) to improve survival through early detection has been the subject of much debate. The prevalence of ultrasound-detected asymptomatic RCC is an important first step to establishing whether a screening programme may be feasible.

Methods
A systematic search of MEDLINE and Embase was performed up to March 2016 to identify studies reporting the prevalence of renal masses and RCC. Two populations of patients were chosen: asymptomatic individuals undergoing screening ultrasonography and patients undergoing ultrasonography for abdominal symptoms not related to RCC. A random-effects meta-analysis was performed. Study quality was evaluated using a validated eight-point checklist.

Results
Sixteen studies (413 551 patients) were included in the final analysis. The pooled prevalence of renal mass was 0·36 (95 per cent c.i. 0·23 to 0·52) per cent and the prevalence of histologically proven RCC was 0·10 (0·06 to 0·15) per cent. The prevalence of RCC was more than double in studies from Europe and North America than in those from Asia: 0·17 (0·09 to 0·27) versus 0·06 (0·03 to 0·09) per cent respectively. Data on 205 screen-detected RCCs showed that 84·4 per cent of tumours were stage T1–T2 N0, 13·7 per cent were T3–T4 N0, and only 2·0 per cent had positive nodes or metastases at diagnosis.

Conclusion
At least one RCC would be detected per 1000 individuals screened. The majority of tumours identified are early stage (T1–T2).
A Homochiral {CoΙΙ16CoΙΙΙ4} Supertetrahedral T4 Cluster from a Racemic Ligand with Ferromagnetic Behavior and High Photocatalytic Activity
Authors: Du Wei , Bai Yue‐Ling , Yin Xiuping , Fang Jianhui , Zhu Shourong , Tao Jun 
Published: April 2017

AbstractA homochiral mixed‐valence cobalt cluster [CoΙΙ16CoΙΙΙ4(μ6‐O)4(μ3‐OH)12(S‐bme)12(OAc)6]Cl6⋅5 CH3OH⋅18 H2O (1, Hbme=1H‐(benzimidazol‐2‐yl)ethanol) was synthesized from a racemic ligand and three cobalt salts of CoCl2⋅6 H2O, Co(Ac)2⋅4 H2O and Co(NO3)2⋅6 H2O in a DMF/MeOH mixed solvent. The enantioselective coordination occurs when a large excess of cobalt ions added in the solution and only the S‐configuration of the racemic ligand involved in crystallization. The CD spectra of three crystal samples show identical Cotton signals, indicating the repeatability and the enantiomeric purity of the single crystals. This compound presents a beautiful two‐shell Matryoshka‐type supertetrahedral T4 cluster constructed by an inner CoΙΙΙ4O4 cubane and four exterior CoΙΙ4O4 cubanes bridged by μ6‐O2− and μ3‐OH− ions. This highest nuclear chiral cobalt cluster is the first example of enantiopure cobalt cluster separated from a racemic ligand and is the largest supertetrahedral cobalt cluster up to now. The magnetic studies reveal it behaves as a ferromagnet. Photocatalytic properties of 1 show high catalytic activities for the degradation of the highly toxic triphenyl dye crystal violet (CV) in the presence of H2O2 under visible light in aqueous solution. The degradation rate almost reach 100 % at 45 min and can maintain 98.54 % after 8 cycles.
Preparation and Characterization of High‐Temperature Non‐Flowing Diurea/Paraffin/Oil Composites as Form‐Stable Phase Change Materials
Authors: Li Hongyu , Zhao Tianbo , Wang Lili 
Published: April 2017

AbstractA series of form‐stable phase change materials (FSPCMs) comprising paraffin as the latent heat storage material, diurea as the supporting material and base oil as the performance improvement agent were prepared. The diurea was synthesized in the system of paraffin/oil directly. A series of characterization was carried out for a deep understanding of shape stability and material properties of diurea‐FSPCMs. The results showed that paraffin and base oil were packaged in the three‐dimensional supra‐molecular structures network which was formed by diurea. The dropping point of the prepared FSPCMs could reach 256 °C and the oil separation rate was as low as 1.19% at 100 °C for 30 h. The results of thermal properties tests showed that the prepared FSPCMs exhibited excellent thermal stability and the FSPCMs remained solid‐like state in the temperature range from 25 to 200 °C. This study proposes a novel method to prepare high‐temperature non‐flowing FSPCMs composites and methods to detect the thermal stability and shape stability of FSPCMs, which is helpful in understanding the shape stability mechanism and broadening the potential application of FSPCMs.
Preparation and Stability Evaluation of Size‐Controllable PDHCA‐β‐CD Nanoparticles as Drug Carrier
Authors: Chu Hong , Zhao Xue , Liu Shirong , Ni Zhongbin , Shi Dongjian , Chen Mingqing 
Published: April 2017

AbstractA novel biocompatible polymer was prepared by grafting the derivate of β‐cyclodextrin (6‐SH‐β‐CD) onto poly(3,4‐dihydroxycinnamic acid) (PDHCA) via Michael addition. PDHCA‐β‐CD nanoparticles were prepared by the self‐assembly of amphiphilic PDHCA‐β‐CD polymer with N,N‐dimethylformamide (DMF) as good solvent and water as poor solvent. The PDHCA‐β‐CD nanoparticles were monodispersed with spherical morphology as shown in the scanning electron microscopic (SEM) images in accord with the result of dynamic light scattering (DLS) measurement. The size of the nanoparticles could be controlled from 60 to 180 nm by tuning the grafting degree (GD) of PDHCA‐β‐CD polymer and also significantly influenced by the amount of water used during the process. These as‐prepared nanoparticles were stable without any significant change in the particle size after six‐months’ storage and even after being irradiated by UV at λ>280 nm for hours. The formation mechanism of PDHCA‐β‐CD nanoparticles was explored. The content of doxorubicin (DOX) loaded onto the nanoparticles was up to 39% with relatively high loading efficiency (approximately 78.8% of initial DOX introduced was loaded). In vitro release studies suggested that DOX released slowly from PDHCA‐β‐CD nanoparticles. These features strongly support the potential of developing PDHCA‐β‐CD nanoparticles as carriers for the controlled delivery of drug.
Progress in Controllable Construction and Energy‐Related Applications of MX2/Graphene and MX2/MX2 Heterostructures
Authors: Yang Pengfei , Zhang Zhepeng , Shi Jianping , Jiang Shaolong , Zhang Yanfeng 
Published: April 2017

AbstractVan der Waals heterostructures have attracted attention worldwide owing to their novel properties and diverse potential applications. Particularly, vertically stacked MX2/graphene (MX2/Gr, M=Mo, W; X=S, Se, etc.) and MX2/MX2 heterostructures have demonstrated their superiority in electronics, optoelectronics and some energy‐related applications. In this Focus Review, we summarize the recent progress in the controllable construction and characterization of MX2/Gr and MX2/MX2 heterostructures, as well as their multiple applications in energy‐related fields. In the first part, we focus on the construction of MX2/Gr heterostructures by the layer‐by‐layer transfer and the direct chemical vapor deposition (CVD) methods, as well as their excellent performance in electronic and optoelectronic devices. We then introduce the direct CVD syntheses, electronic properties and photocatalytic activities of MX2/MX2 heterostructures. Finally, the current challenges and opportunities for such systems are discussed.