bluuebunny/crossref_metadata_2025_split huggingface dataset:
The frequency of intravenous medication administration errors related to smart infusion pumps: a multihospital observational study
Authors: Schnock Kumiko O , Dykes Patricia C , Albert Jennifer , Ariosto Deborah , Call Rosemary , Cameron Caitlin , Carroll Diane L , Drucker Adrienne G , Fang Linda , Garcia-Palm Christine A , Husch Marla M , Maddox Ray R , McDonald Nicole , McGuire Julie , Rafie Sally , Robertson Emilee , Saine Deb , Sawyer Melinda D , Smith Lisa P , Stinger Kristy Dixon , Vanderveen Timothy W , Wade Elizabeth , Yoon Catherine S , Lipsitz Stuart , Bates David W 
Published: April 2016

IntroductionIntravenous medication errors persist despite the use of smart pumps. This suggests the need for a standardised methodology for measuring errors and highlights the importance of identifying issues around smart pump medication administration in order to improve patient safety.ObjectivesWe conducted a multisite study to investigate the types and frequency of intravenous medication errors associated with smart pumps in the USA.Methods10 hospitals of various sizes using smart pumps from a range of vendors participated. Data were collected using a prospective point prevalence approach to capture errors associated with medications administered via smart pumps and evaluate their potential for harm.ResultsA total of 478 patients and 1164 medication administrations were assessed. Of the observed infusions, 699 (60%) had one or more errors associated with their administration. Identified errors such as labelling errors and bypassing the smart pump and the drug library were predominantly associated with violations of hospital policy. These types of errors can result in medication errors. Errors were classified according to the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP). 1 error of category E (0.1%), 4 of category D (0.3%) and 492 of category C (excluding deviations of hospital policy) (42%) were identified. Of these, unauthorised medication, bypassing the smart pump and wrong rate were the most frequent errors.ConclusionWe identified a high rate of error in the administration of intravenous medications despite the use of smart pumps. However, relatively few errors were potentially harmful. The results of this study will be useful in developing interventions to eliminate errors in the intravenous medication administration process.
Building consensus for the future of paediatric simulation: a novel ‘KJ Reverse-Merlin’ methodology
Authors: Hunt Elizabeth A , Duval-Arnould Jordan , Chime Nnenna O , Auerbach Marc , Kessler David , Duff Jonathan P , Shilkofski Nicole , Brett-Fleegler Marissa , Nadkarni Vinay , Cheng Adam 
Published: April 2016

ObjectivesThis project aims to identify guiding strategic principles to optimise simulation-based educational impact on learning, patient safety and child health.MethodsStudy participants included 39 simulation experts who used a novel ‘KJ Reverse-Merlin’ consensus process in the systematic identification of barriers to success in simulation, grouped them in themes and subsequently identified solutions for each theme.Results193 unique factors were identified and clustered into 6 affinity groups. 6 key consensus strategies were identified: (1) allocate limited resources by engaging health systems partners to define education and research priorities; (2) conduct and publish rigorous translational and cost-effectiveness research; (3) foster collaborative multidisciplinary research and education networks; (4) design simulation solutions with systems integration and sustainability in mind; (5) leverage partnerships with industry for simulation, medical and educational technology; (6) advocate to engage the education community, research funding agencies and regulatory bodies.ConclusionsSimulation can be used as a research, quality improvement and or educational tool aimed at improving the quality of care provided to children. However, without organisation, strategy, prioritisation and collaboration, the simulation community runs the risk of wasting resources, duplicating and misdirecting the efforts.
Fatigue in transportation: NTSB investigations and safety recommendations
Authors: Marcus Jeffrey H , Rosekind Mark R 
Published: April 2016

ObjectiveWe aim to place into the scientific literature information on the prevalence of operator fatigue as a factor in causing transportation mishaps, and the categories of improvements identified to address fatigue in transportation.MethodsWe analyzed the number of major National Transportation Safety Board (NTSB) investigations that identified fatigue as a probable cause, contributing factor, or a finding. We divided all NTSB recommendations addressing fatigue issued since the agency was founded into 7 subject categories, and placed each recommendation into the appropriate category. This information was then analyzed to determine the number of recommendations in each category, both overall and by transportation mode. Analysis was also performed regarding the types of organizations that received the recommendations, whether the recommended actions have been taken, and the NTSB's evaluation of whether the action taken satisfied a given recommendation.ResultsWe reviewed 182 major NTSB investigations completed between 1 January 2001 and 31 December 2012 and found that 20% of these investigations identified fatigue as a probable cause, contributing factor, or a finding. The presence of fatigue varied between among the modes of transportation, ranging from 40% of highway investigations to 4% of marine investigations. The first NTSB recommendation to address the safety risks associated with human fatigue was issued over 40 years ago, in 1972. Since then, the NTSB has issued 205 separate fatigue-specific recommendations. Scheduling policies and practices was the most common subject category accounting for 40% of all recommendations issued. Federal agencies received 54% of all recommendations, with 22% to transportation operators, and 16% to associations. Of all NTSB fatigue recommendations, 24% were open ranging from a low of 9% in highway to 39% in aviation. Overall, only 3% of open recommendations were classified “unacceptable,” whereas 16% of all closed recommendations were classified “unacceptable.”ConclusionsAlthough there has been over 100 years of progress in recognizing and addressing the safety risk posed by human fatigue in transportation, 20% of recent NTSB investigations have identified fatigue as a probable cause, contributing factor or finding. This analysis represents the first-ever examination of fatigue identified in major NTSB investigations across modes and of the focus, recipients, and classification status of fatigue-related safety recommendations. It demonstrates that fatigue remains a significant transportation safety risk.
Exercise training characteristics in cardiac rehabilitation programmes: a cross-sectional survey of Australian practice
Authors: Abell Bridget , Glasziou Paul , Briffa Tom , Hoffmann Tammy 
Published: April 2016

IntroductionExercise training is a core component of cardiac rehabilitation (CR), however, little information exists regarding the specific exercise interventions currently provided for coronary heart disease in Australian practice. We aimed to analyse the current status of exercise-based CR services across Australia.DesignCross-sectional survey.MethodsAustralian sites offering exercise-based CR were identified from publically available directories. All sites were invited by email to participate in an online Survey Monkey questionnaire between October 2014 and March 2015, with reminders via email and phone follow-up. Questions investigated the demographics and format of individual programmes, as well as specific exercise training characteristics.Results297 eligible programmes were identified, with an 82% response rate. Most sites (82%) were based at hospital or outpatient centres, with home (15%), community (18%) or gym-based options (5%) less common. While CR was most often offered in a comprehensive format (72% of sites), the level of exercise intervention varied greatly among programmes. Most frequently, exercise was prescribed 1–2 times per week for 60 min over 7 weeks. Almost one-quarter (24%) had a sole practitioner supervising exercise, although the majority used a nurse/physiotherapist combination. Low to moderate exercise intensities were used in 60% of programmes, however, higher intensity prescriptions were not uncommon. Few sites (<6%) made use of technology, such as mobile phones or the internet, to deliver or support exercise training.ConclusionsWhile advances have been made towards providing flexible and accessible exercise-based CR, much of Australia's service remains within traditional models of care. A continuing focus on service improvement and evidence-based care should, therefore, be considered a core aim of those providing exercise for CR in order to improve health service delivery and optimise outcomes for patients.
Use of fixed-wing and multi-rotor unmanned aerial vehicles to map dynamic changes in a freshwater marsh
Authors: Marcaccio James V. , Markle Chantel E. , Chow-Fraser Patricia 
Published: April 2016

We used a multi-rotor (Phantom 2 Vision+, DJI) and a fixed-wing (eBee, senseFly) unmanned aerial vehicle (UAV) to acquire high-spatial-resolution composite photos of an impounded freshwater marsh during late summer in 2014 and 2015. Dominant type and percent cover of three vegetation classes (submerged aquatic, floating or emergent vegetation) were identified and compared against field data collected in 176 (2 m × 2 m) quadrats during summer 2014. We also compared these data against the most recently available digital aerial true colour, high-resolution photographs provided by the government of Ontario (Southwestern Ontario Orthophotography Project (SWOOP), May 2010), which are free to researchers but taken every 5 years in leaf-off spring conditions. The eBee system produced the most effective data for determining percent cover of floating and emergent vegetation (58% and 64% overall accuracy, respectively). Both the eBee and the Phantom were comparable in their ability to determine dominant habitat types (moderate kappa agreement) and were superior to SWOOP in this respect (poor kappa agreement). UAVs can provide a time-sensitive, flexible, and affordable option to capture dynamic seasonal changes in wetlands, information that ecologists often require to study how species at risk use their habitat.
M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo 
Published: April 2016

Abstract
The Golgi apparatus is responsible for transporting, processing, and sorting numerous proteins in the cell, including cell surface-expressed receptor tyrosine kinases (RTK). The small-molecule compound M-COPA [2-methylcoprophilinamide (AMF-26)] disrupts the Golgi apparatus by inhibiting the activation of Arf1, resulting in suppression of tumor growth. Here, we report an evaluation of M-COPA activity against RTK-addicted cancers, focusing specifically on human gastric cancer (GC) cells with or without MET amplification. As expected, the MET-addicted cell line MKN45 exhibited a better response to M-COPA than cell lines without MET amplification. Upon M-COPA treatment, cell surface expression of MET was downregulated with a concurrent accumulation of its precursor form. M-COPA also reduced levels of the phosphorylated form of MET along with the downstream signaling molecules Akt and S6. Similar results were obtained in additional GC cell lines with amplification of MET or the FGF receptor FGFR2. MKN45 murine xenograft experiments demonstrated the antitumor activity of M-COPA in vivo. Taken together, our results offer an initial preclinical proof of concept for the use of M-COPA as a candidate treatment option for MET-addicted GC, with broader implications for targeting the Golgi apparatus as a novel cancer therapeutic approach. Cancer Res; 76(13); 3895–903. ©2016 AACR.
Secretory TRAIL-Armed Natural Killer Cell–Based Therapy: In Vitro and In Vivo Colorectal Peritoneal Carcinomatosis Xenograft
Authors: Song Xinxin , Hong Se-Hoon , Kwon William T. , Bailey Lisa M. , Basse Per , Bartlett David L. , Kwon Yong Tae , Lee Yong J. 
Published: April 2016

Abstract
Since its discovery in 1995, TNF-related apoptosis-inducing ligand (TRAIL) has sparked growing interest among oncologists due to its remarkable ability to induce apoptosis in malignant human cells, but not in most normal cells. However, one major drawback is its fast clearance rate in vivo. Thus, the development of an alternative means of delivery may increase the effectiveness of TRAIL-based therapy. In this study, we developed a secretory TRAIL-armed natural killer (NK) cell–based therapy and assessed its cytotoxic effects on colorectal cancer cells and its tumoricidal efficacy on colorectal peritoneal carcinomatosis xenograft. We generated genetically modified NK cells by transduction with a lentiviral vector consisting of a secretion signal domain, a trimerization domain, and an extracellular domain of the TRAIL gene. These NK cells secreted a glycosylated form of TRAIL fusion protein that induced apoptotic death. Intraperitoneally, but not intravenously, injected NK cells effectively accumulated at tumor sites, infiltrated tumor tissue, induced apoptosis, and delayed tumor growth. These results shed light on the therapeutic potential of genetically engineered NK cells to treat peritoneal carcinomatosis. Mol Cancer Ther; 15(7); 1591–601. ©2016 AACR.
The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma
Authors: Couch George , Redman James E. , Wernisch Lorenz , Newton Richard , Malhotra Shalini , Dawsey Sanford M. , Lao-Sirieix Pierre , Fitzgerald Rebecca C. 
Published: April 2016

Abstract
The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are esophageal squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomarker analysis could reduce the subjectivity associated with histologic assessment of dysplasia and thus improve diagnostic accuracy. The aims of this study were therefore to identify biomarkers for esophageal squamous dysplasia and carcinoma. A publicly available dataset was used to identify genes with differential expression in ESCC compared with normal esophagus. Each gene was ranked by a support vector machine separation score. Expression profiles were examined, before validation by qPCR and IHC. We found that 800 genes were overexpressed in ESCC compared with normal esophagus (P &lt; 10−5). Of the top 50 genes, 33 were expressed in ESCC epithelium and not in normal esophagus epithelium or stroma using the Protein Atlas website. These were taken to qPCR validation, and 20 genes were significantly overexpressed in ESCC compared with normal esophagus (P &lt; 0.05). TNFAIP3 and CHN1 showed differential expression with IHC. TNFAIP3 expression increased gradually through normal esophagus, mild, moderate and severe dysplasia, and SCC (P &lt; 0.0001). CHN1 staining was rarely present in the top third of normal esophagus epithelium and extended progressively towards the surface in mild, moderate, and severe dysplasia, and SCC (P &lt; 0.0001). Two novel promising biomarkers for ESCC were identified, TNFAIP3 and CHN1. CHN1 and TNFAIP3 may improve diagnostic accuracy of screening methods for ESCC. Cancer Prev Res; 9(7); 558–66. ©2016 AACR.
Characteristics and Outcomes of Stroke Patients Transferred to Hospitals Participating in the Michigan Coverdell Acute Stroke Registry
Authors: Nickles Adrienne V. , Roberts Stacey , Shell Erin , Mitchell Marylou , Hussain Syed , Lyon-Callo Sarah , Reeves Mathew J. 
Published: April 2016

Background—
Interhospital transfer of acute stroke patients is becoming increasingly important as regional stroke systems of care continue to evolve. We describe the characteristics and outcomes of stroke cases transferred to hospitals participating in the Michigan Coverdell Stroke Registry.

Methods and Results—

Thirty-six hospitals participated in the Michigan registry during 2009 to 2011. Transfer patients were transferred from another hospital either acutely or after admission. Multivariable logistic regression was used to determine predictors of transfer and the independent association between transfer and in-hospital mortality and complications. Of 16 202 acute stroke admissions, 19.1% were transferred. Independent predictors of being transferred included younger age, hemorrhagic stroke, and higher stroke severity, but having a past history of stroke decreased the likelihood of being transferred. Transferred cases had higher in-hospital mortality (12.0% versus 6.4%;
P
<0.001) compared with regular admissions and were more likely to suffer complications (18.4% versus 12.8%;
P
<0.001). These differences remained after adjustment for confounding variables (adjusted odds ratio for mortality =1.32, 95% confidence interval 1.12, 1.56; adjusted odds ratio for complications =1.39, 95% confidence interval 1.22, 1.58). Among ischemic stroke, elevated odds of poor outcomes among transferred patients remained after adjustment for stroke severity.

Conclusions—
Transferred patients represent a complex admixture of patient characteristics that result in higher risks of poor outcomes. Our results suggest that it is prudent to account for patient transfer status when comparing hospital outcomes and that stroke registries need to expand their data collection capacity to provide a better understanding of the relative benefits and risks of transferring patients.
A Comparison of Temperature Data from Automated and Manual Observing Networks in Georgia and Impacts of Siting Characteristics
Authors: Allard Jason , Vincent Paul C. , McElwaney Jeromy R. , Hoogenboom Gerrit 
Published: April 2016

AbstractThe objectives of this study were to compare average monthly and seasonal maximum and minimum temperatures of the Georgia Automated Environmental Monitoring Network (AEMN) to those of geographically close (i.e., paired) manual observations from U.S. Historical Climatology Network (USHCN) stations and Cooperative Observer Program (COOP) stations for the period 2002–13, and to evaluate the extent to which differences in siting characteristics of paired AEMN–USHCN stations contribute to the temperature differences. Correlations for monthly and seasonal maximum and minimum temperatures of paired AEMN–USHCN and AEMN–COOP stations were high and almost always significant, although the correlations for seasonal minimum temperatures were slightly lower than those of maximum temperatures, especially for summer. Monthly maximum and minimum temperatures and seasonal maximum temperatures of paired AEMN–USHCN and AEMN–COOP stations were significantly different in only a few instances, while seasonal minimum temperatures were more often significantly different, particularly for summer. The stronger relationship between maximum temperatures than minimum temperatures for paired stations is logical given that minimum temperatures typically occur when a shallow, decoupled nocturnal boundary layer is more sensitive to local conditions [e.g., land use/land cover (LULC)]. Stepwise regressions confirmed that a portion of the variance of seasonal minimum temperatures of paired AEMN–USHCN stations was explained by differences in LULC, while the variance in seasonal maximum temperatures was explained better by differences in elevation. Despite the generally close relationships between temperatures of paired stations and a portion of the differences being explained, an abrupt change from manual networks to the AEMN without data adjustments would change the Georgia climate record on monthly and seasonal time scales.
Quantification of the Effect of Water Temperature on the Fall Rate of Expendable Bathythermographs
Authors: Abraham John P. , Cowley Rebecca , Cheng Lijing 
Published: April 2016

AbstractA very large portion of the historical information on ocean temperatures has been measured using expendable bathythermograph (XBT) devices. For decades, these devices provided the majority of global information. It is, therefore, important to quantify their accuracy and identify biases in this important historical dataset. Here, calculations are made of the influence of water temperature on the rate of descent of the XBT devices into the ocean waters. In colder regions, the larger viscosity of the water is expected to cause a greater drag force on the device, which would slow the descent. It was found through computational fluid dynamic models that the impact of temperature and viscosity on the probe descent is approximately 2.2% for water temperatures that range from 0° to 27°C. Probe-specific temperature-dependent fall rate equations were applied to 269 collocated XBT/conductivity–temperature–depth (CTD) measurements from two different research cruises. It was found that the probe-specific descent equations were an improvement over the uncorrected method. Next, in an effort to automate the process, the fall rate coefficients were related to the topmost measured temperature in the water column. With this relationship, comparisons were made between the probe-specific descent calculations and 2937 high-resolution XBT–CTD pairs. It was found that again, the new methodology outperformed the standard fall rate equation. The new method was also compared with an independent correction method that was previously published. It was found that both new methods were improvements upon the industry-standard fall rate calculation. Subsequent calculations using the top-100-m water temperature were performed and were found to be statistically insignificant compared to the proposed simplified method.
The Role of Surgery in Management of Samter’s Triad
Authors: Adelman Julie , McLean Caitlin , Shaigany Kevin , Krouse John H. 
Published: April 2016

ObjectiveAspirin‐exacerbated respiratory disease (AERD) represents a severe form of chronic rhinosinusitis (CRS) characterized by nasal polyposis, bronchial asthma, and aspirin intolerance. This syndrome, known as Samter’s triad, is more difficult to manage than routine CRS and poses a challenge to the treating clinician. We performed a systematic review of the literature to determine the role of endoscopic sinus surgery in patients with AERD who are on adjuvant medical therapies.Data SourcesPubMed, Embase, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Cochrane Technology Assessments, Cochrane Economic Evaluations, Cochrane Groups, and Clinicaltrials.gov.Review MethodsA systematic review of the literature was performed using the 2009 PRISMA guidelines. Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery were considered appropriate for inclusion. Publications were written in English, included patients aged 18 years or older, and had a minimum follow‐up of 3 months.ResultsEighteen studies met criteria for inclusion in our review. The primary outcome was change in symptom profile as measured by sinonasal and asthma symptom scores. Most studies demonstrated improvement in sinus‐ and asthma‐related symptoms and quality‐of‐life measures after endoscopic sinus surgery.ConclusionThis review, which did not exclude the use of concomitant medical therapy, suggests that surgery is beneficial in AERD management. Evidence demonstrates improvement in sinonasal and asthma symptom severity and frequency, radiographic and endoscopy scores, and quality of life after surgery.