bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caval Subtraction 2D Phase-Contrast MRI to Measure Total Liver and Hepatic Arterial Blood Flow
Authors: Chouhan Manil D. , Mookerjee Rajeshwar P. , Bainbridge Alan , Punwani Shonit , Jones Helen , Davies Nathan , Walker-Samuel Simon , Patch David , Jalan Rajiv , Halligan Steve , Lythgoe Mark F. , Taylor Stuart A. 
Published: November 2016

Objectives
Caval subtraction phase-contrast magnetic resonance imaging (PCMRI) noninvasive measurements of total liver blood flow (TLBF) and hepatic arterial (HA) flow have been validated in animal models and translated into normal volunteers, but not patients. This study aims to demonstrate its use in patients with liver cirrhosis, evaluate measurement consistency, correlate measurements with portal hypertension severity, and invasively validate TLBF measurements.

Materials and Methods
Local research ethics committee approval was obtained. Twelve patients (mean, 50.8 ± 3.1 years; 10 men) with histologically confirmed cirrhosis were recruited prospectively, undergoing 2-dimensional PCMRI of the portal vein (PV) and the infrahepatic and suprahepatic inferior vena cava. Total liver blood flow and HA flow were estimated by subtracting infrahepatic from suprahepatic inferior vena cava flow and PV flow from estimated TLBF, respectively. Invasive hepatic venous pressure gradient (HVPG) and indocyanine green (ICG) clearance TLBF were measured within 7 days of PCMRI. Bland-Altman (BA) analysis of agreement, coefficients of variation, and Pearson correlation coefficients were calculated for comparisons with direct inflow PCMRI, HVPG, and ICG clearance.

Results
The mean difference between caval subtraction TLBF and direct inflow PCMRI was 6.3 ± 4.2 mL/min/100 g (BA 95% limits of agreement, ±28.7 mL/min/100 g). Significant positive correlations were observed between HVPG and caval subtraction HA fraction (r = 0.780, P = 0.014), but not for HA flow (r = 0.625, P = 0.053), PV flow (r = 0.244, P = 0.469), or caval subtraction TLBF (r = 0.473, P = 0.141). Caval subtraction and ICG TLBF agreement was modest (mean difference, −32.6 ± 16.6 mL/min/100 g; BA 95% limits of agreement, ±79.7 mL/min/100 g), but coefficients of variation were not different (65.7% vs 48.1%, P = 0.28).

Conclusions
In this proof-of-principle study, caval subtraction PCMRI measurements are consistent with direct inflow PCMRI, correlate with portal hypertension severity, and demonstrate modest agreement with invasive TLBF measurements. Larger studies investigating the clinical role of TLBF and HA flow measurement in patients with liver disease are justified.
High temporal resolution of gene expression dynamics in developing mouse embryonic stem cells
Authors: Gloss Brian S. , Signal Bethany , Cheetham Seth W. , Gruhl Franziska , Kaczorowski Dominik , Perkins Andrew C. , Dinger Marcel E. 
Published: November 2016

AbstractInvestigations of transcriptional responses during developmental transitions typically use time courses with intervals that are not commensurate with the timescales of known biological processes. Moreover, such experiments typically focus on protein-coding transcripts, ignoring the important impact of long noncoding RNAs. We evaluated coding and noncoding expression dynamics at high temporal resolution (6-hourly) in differentiating mouse embryonic stem cells and report the effects of increased temporal resolution on the characterization of the underlying molecular processes. We present a refined resolution of global transcriptional alterations, including regulatory network interactions, coding and noncoding gene expression changes as well as alternative splicing events, many of which cannot be resolved by existing coarse developmental time-­-courses. We describe novel short lived and cycling patterns of gene expression and temporally dissect ordered gene expression at bidirectional promoters and responses to transcription factors. These findings demonstrate the importance of temporal resolution for understanding gene interactions in mammalian systems.Links to dataData has been deposited into GEO: The Reviewer access link is:http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=cnglummejbkltyj@acc=GSE75028
Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts
Authors: Longdon Ben , Day Jonathan P , Schulz Nora , Leftwich Philip T , de Jong Maaike A , Breuker Casper J , Gibbs Melanie , Obbard Darren J , Wilfert Lena , Smith Sophia CL , McGonigle John E , Houslay Thomas M , Wright Lucy I , Livraghi Luca , Evans Luke C , Friend Lucy A , Chapman Tracey , Vontas John , Kambouraki Natasa , Jiggins Francis M 
Published: November 2016

AbstractA small number of free-living viruses have been found to be obligately vertically transmitted, but it remains uncertain how widespread vertically transmitted viruses are and how quickly they can spread through host populations. Recent metagenomic studies have found several insects to be infected with sigma viruses (Rhabdoviridae). Here, we report that sigma viruses that infect Mediterranean fruit flies (Ceratitis capitata),Drosophila immigrans, and speckled wood butterflies (Pararge aegeria) are all vertically transmitted. We find patterns of vertical transmission that are consistent with those seen inDrosophilasigma viruses, with high rates of maternal transmission, and lower rates of paternal transmission. This mode of transmission allows them to spread rapidly in populations, and using viral sequence data we found the viruses inD. immigransandC. capitatahad both recently swept through host populations. The viruses were common in nature, with mean prevalences of 12% inC. capitata,38% inD. immigransand 74% inP. aegeria. We conclude that vertically transmitted rhabdoviruses may be widespread in insects, and that these viruses can have dynamic interactions with their hosts.
Urban food retailing and food prices in Africa: the case of Addis Ababa, Ethiopia
Authors: Assefa Thomas , Abebe Girum , Lamoot Indra , Minten Bart 
Published: November 2016

PurposeDespite the large interest in urban food markets, there are, however still relatively few good studies that have empirically documented the functioning of retail markets in developing countries, especially in Africa. The purpose of this paper is to look in particular at the case of Addis Ababa, a city of more than four million people and the capital of Ethiopia, one of the most populous countries in Sub-Saharan Africa. To better understand urban food retail, the authors rely on a large primary survey.Design/methodology/approachTo better understand urban food retail, the authors rely on a large primary survey. Based on a stratified sampling scheme representative for the city as a whole, 1,226 urban food retail outlets were interviewed in March and April 2012.FindingsThe authors find increasing differentiation in food retail markets in recent years. Despite the prohibition of foreign direct investment in food retail, a domestic modern private retail sector is quickly emerging. However, its share is still very small and, in contrast to roll-outs of modern retail in other countries, it has not yet entered the cereal sector, which remains in the hands of local flour mills, cereal shops, and cooperative retail outlets. The importance of cooperative retail is growing even more rapidly. It is especially important for those products where supply chains are controlled by the government. On the high-end, domestic private modern retail outlets deliver high-quality products at significantly higher prices,ceteris paribus. At the other side, the authors see cooperative retail that delivers food at significantly lower – and subsidized – prices. However, the latter shops are characterized by typical price control problems, reflected in regular lack of supplies and queuing.Research limitations/implicationsThe study is limited to the city of Addis Ababa and it seems useful if similar studies could be conducted in other cities in Africa.Originality/valueDespite the large interest in urban food markets, there are still relatively few good studies that have empirically documented the functioning of retail markets in developing countries, especially in Africa. The paper therefore contributes to fill this lacuna by studying urban food retail markets using new and unique data for Africa.
Can futures markets accommodate Indian farmers?
Authors: Dey Kushankur , Maitra Debasish 
Published: November 2016

PurposeIt has become an ongoing debate whether Indian commodity futures markets can accommodate farmers. The purpose of this paper is to examine whether Indian commodity futures markets help rationalize farmers’ price expectation. The study starts with questions on the efficiency and other roles of commodity futures markets.Design/methodology/approachFrom a sectoral standpoint and economic importance, the study considers pepper, coffee, and natural rubber (NR) futures and spot markets. The efficiency of futures markets, divergence/convergence and causality between futures and spot markets have been studied by employing co-integrations, error correction and causality models. The sample period of the data are taken from the inception of futures trading. These three commodities are also compared on the basis of trading at the futures markets vs spot markets.FindingsAnalysis shows that though pepper futures market is informationally efficient in price discovery, while coffee and NR spot markets do the process faster. Pepper and coffee futures and spot prices exhibit the convergence; NR shows a sign of divergence. Unidirectional causality from pepper futures to spot market is observed wherein the former was weakly exogenous to the latter and while, bidirectional causality is observed in coffee and rubber. Coffee spot appears weakly exogenous while this remains inconclusive in the case of NR.Research limitations/implicationsThe authors analyzed the futures markets in rationalizing the spot market price in three plantation crops in India. In order to make the study more generalizable, further research is warranted in other commodities including those prices of which are government regulated.Originality/valueThe paper is unique in terms of understanding the interaction or interrelationship between futures markets and spot markets and drawing inferences about the role of futures markets in price formation in plantation commodities like pepper, coffee and NR.
Discovering myself, a journey of rediscovery
Authors: Roeg Waldo 
Published: November 2016

Purpose
The purpose of this paper is to describe the experiences of one person’s journey of recovery and use these as the basis for reflection on things that assist people in this journey.

Design/methodology/approach
A reflective approach is used to consider things assist the process of recovering a life with mental health and addiction problems.

Findings
Reflections are presented on the factors facilitating recovery focusing on those things that contributed to finding hope, taking back control and discovering opportunity.

Originality/value
This narrative account contributes to the peer literature on recovery.
Reflections on the social model of distress or madness: how to make the social model of disability accessible to people with mental health challenges
Authors: Kinn Angela 
Published: November 2016

Purpose
The purpose of this paper is to explore the relationships between recovery approaches and the social model of disability developed within the broader disability movement.

Design/methodology/approach
Personal narrative and reflective account written from the perspective of a senior peer trainer with reference to selected literature.

Findings
It is important to embrace a social model and rights-based approach within recovery approaches.

Originality/value
An original viewpoint on the perspective of a peer trainer linking recovery approaches to the social model and rights-based approach developed within the broader disability arena.
Kayleigh Beard-Blackband in conversation with Jerome Carson
Authors: Beard-Blackband Kayleigh , Carson Jerome 
Published: November 2016

Purpose
The purpose of this paper is to provide a profile of Kayleigh Beard-Blackband.

Design/methodology/approach
Kayleigh provides a short biographical description of her life. She is then interviewed by Jerome.

Findings
Kayleigh achieved so much while under intense domestic and academic pressure. This gives her hope that she will be able to recover from recurrent depression.

Research limitations/implications
Single case studies are of course only one person’s story. However, they can offer key personal insights and provide encouragement to others.

Practical implications
Kayleigh’s comments “It is easy to fall off the radar in mental health services”, suggest services need to ensure that all referrals are followed up.

Social implications
Services need to offer individuals the help that they want. Many will have a preference for individual over group treatments. People should be offered a choice.

Originality/value
Kayleigh’s story is a remarkable account of survival and growth against all the odds.
The Choice of Canned Whole Peeled Tomatoes is Driven by Different Key Quality Attributes Perceived by Consumers Having Different Familiarity with the Product
Authors: Frez‐Muñoz Lucía , Steenbekkers Bea (LPA) , Fogliano Vincenzo 
Published: November 2016

AbstractCanned whole peeled tomatoes are a premium tomato product; however, no information is available about the key intrinsic and extrinsic quality attributes perceived by consumers when buying this product. This research considered consumers differing in the level of familiarity with peeled tomatoes, that is, knowledge, frequency of consumption, and availability of this product, on 3 markets: Chile (low), The Netherlands (medium), and Italy (high). The perceptions and preferences of each group were studied using first focus groups and subsequently conjoint analysis in order to identify the key quality attributes leading their preferences for this product. Focus groups identified 7 intrinsic attributes (color, packing medium, tomato consistency, acidity level, sweetness level, extra ingredients, and intensity of product taste), and 5 extrinsic attributes (packaging material, product type, country of origin, brand, and label design). Significant variations according to the familiarity were found. The conjoint analyses showed that color of tomatoes was the most important intrinsic quality attribute for all groups, while packaging material was the most important extrinsic quality attribute for Chileans and Dutch, being a glass container or a can with easy open the preferred packaging for respective groups. In contrast, country of origin was the most important parameter for Italians. We concluded that intrinsic and extrinsic attributes were strongly influenced by the degree of familiarity with canned whole peeled tomatoes.
Ten false ideas about New Caledonia biogeography
Authors: Grandcolas Philippe 
Published: November 2016

AbstractThe biogeographical paradigm of New Caledonia has recently changed. Although this island is now considered by many as oceanic, its study is still often impeded by some old misconceptions concerning either regional geology or phylogenetic analysis of evolution and biogeography. I discuss ten points that I feel are especially detrimental, to help focus on the real debate and the real questions: (1) its geological history cannot be understood from the basement only; (2) the island submergence was not due simply to sea‐level variation; (3) Zealandia/Tasmantis is not a lost continent; (4) short‐distance dispersal is not equivalent to permanence on land; (5) long‐distance dispersal is not the sole event opposing vicariance, but short‐distance dispersal as well; (6) the occurrence of relicts does not prove biota permanence; (7) a major fault system was not observed in New Caledonia; (8) terranes are not rafts; (9) forest climatic refuges do not necessarily equate to centres of endemism or centres of diversity; and (10) New Caledonia is not only a sink but also a source. Study of New Caledonia will need to focus on old and non‐relict clades and there is a need to improve the local fossil record.
Does prior antiplatelet therapy influence hematoma volume and hematoma growth following intracerebral hemorrhage? Results from a prospective study and a meta‐analysis
Authors: Camps‐Renom P. , Alejaldre‐Monforte A. , Delgado‐Mederos R. , Martínez‐Domeño A. , Prats‐Sánchez L. , Pascual‐Goñi E. , Martí‐Fàbregas J. 
Published: November 2016

Background and purposeLarge baseline hematoma volume (HV) and hematoma growth (HG) are related to poor outcome in patients with intracerebral hemorrhage (ICH). It remains controversial whether prior antiplatelet therapy (APT) influences baseline HV and HG, and the outcome following ICH.MethodsWe collected clinical and radiological data from a prospective cohort of patients diagnosed with ICH within 24 h of symptom onset. Prior APT was ascertained from the clinical history. In patients for whom a follow‐up computed tomography (CT) was available within 72 h, we assessed HG, defined as an increase of ≥33% and/or ≥12.5 mL in the HV. We assessed mortality and functional outcome during follow‐up with the Rankin scale. To perform a meta‐analysis, we searched for published studies reporting HG according to previous APT and pooled the available data.ResultsWe included 223 patients (mean age 72.5 ± 13 years). Previous APT was reported in 74 patients (33.2%). The linear regression model showed that prior APT was independently associated with larger baseline HV. HG was detected in 49 of 130 patients (37.7%) and no differences related to prior APT were observed among our cohort. However, after pooling the data of seven studies in the meta‐analysis, prior APT showed an increase in HG frequency (odds ratio, 1.85; 95% confidence interval, 1.37–2.5). Patients who received APT presented with worse outcome during follow‐up, although this difference was not significant (P = 0.06).ConclusionsIn the current study, prior APT was related to larger baseline HV in patients with ICH. Data from the meta‐analysis also showed a higher risk of HG associated with APT.
A typology of fisheries management tools: using experience to catalyse greater success
Authors: Selig Elizabeth R , Kleisner Kristin M , Ahoobim Oren , Arocha Freddy , Cruz‐Trinidad Annabelle , Fujita Rod , Hara Mafaniso , Katz Laure , McConney Patrick , Ratner Blake D , Saavedra‐Díaz Lina M , Schwarz Anne‐Maree , Thiao Djiga , Torell Elin , Troëng Sebastian , Villasante Sebastian 
Published: November 2016

AbstractFisheries provide nutrition and livelihoods for coastal populations, but many fisheries are fully or over‐exploited and we lack an approach for analysing which factors affect management tool performance. We conducted a literature review of 390 studies to assess how fisheries characteristics affected management tool performance across both small‐scale and large‐scale fisheries. We defined success as increased or maintained abundance or biomass, reductions in fishing mortality or improvements in population status. Because the literature only covered a narrow set of biological factors, we also conducted an expert elicitation to create a typology of broader fishery characteristics, enabling conditions and design considerations that affect performance. The literature suggested that the most commonly used management tool in a region was often the most successful, although the scale of success varied. Management tools were more often deemed successful when used in combination, particularly pairings of tools that controlled fishing mortality or effort with spatial management. Examples of successful combinations were the use of catch limits with quotas and limited entry, and marine protected areas with effort restrictions. The most common factors associated with inadequate biological performance were ‘structural’ issues, including poor design or implementation. The expert‐derived typologies revealed strong local leadership, high community involvement and governance capacity as common factors of success across management tool categories (i.e. input, output and technical measures), but the degree of importance varied. Our results are designed to inform selection of appropriate management tools based on empirical data and experience to increase the likelihood of successful fisheries management.
Optimization of blood sample collection with timing and quality constraints
Authors: Elalouf Amir , Tsadikovich Dmitry , Hovav Sharon 
Published: November 2016

AbstractWe focus on planning transportation operations within a blood sample supply chain, which comprises clinics and a laboratory. Specifically, the main goal of this study is to obtain the optimal number of vehicles to be deployed and the scheduling of the pickup process. First, we formulate a mixed‐integer programming (MIP) problem. Next, we develop a heuristic scheme composed of two heuristic algorithms and numerical search, and a new genetic algorithm. In an extensive numerical study, based on the data from a real‐life blood sample collection process, we illustrate the potential of the new heuristic scheme.
Reintroduction strategy for the Andean Condor Conservation Program, Argentina
Authors: Astore V. , Estrada R. , Jácome N. L. 
Published: November 2016

The Andean condor Vultur gryphus is the largest bird in the world with flight capacity. For thousands of years the Andean condor has been honoured as a sacred link between space and humans by indigenous communities. In the last 100 years, the range of this emblematic species contracted rapidly and the Andean condor was pronounced extinct at both ends of its endemic South American range, in Venezuela and on the Atlantic coast of Patagonia. The Andean condor appears in Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora and is listed as in ‘Danger of Extinction’ by the United States Fish and Wildlife Service. In addition, according to the International Union for Conservation of Nature, this species is classified as Near Threatened. In 1991, the Andean Condor Conservation Program (PCCA: Programa Conservación Cóndor Andino) was founded in Argentina. The PCCA started by performing genetic analyses and documenting the condor population in zoological institutions in a Latin American regional studbook. The PCCA then developed artificial‐incubation programmes and techniques for hand rearing birds without human contact, and worked to rescue and rehabilitate wild condors. The PCCA has succeeded in rearing 57 chicks and rescuing 197 wild condors. This paper describes the strategy used by the PCCA to reintroduce 160 condors throughout South America.