bluuebunny/crossref_metadata_2025_split huggingface dataset:
The IMPACT Study (Influence of Sensor-Equipped Microcatheters on Coronary Hemodynamics and the Accuracy of Physiological Indices of Functional Stenosis Severity)
Authors: Wijntjens Gilbert W.M. , van de Hoef Tim P. , Kraak Robin P. , Beijk Marcel A. , Sjauw Krischan D. , Vis M. Marije , Madera Cambero Maribel I. , Brinckman Stijn L. , Plomp Jacobus , Baan Jan , Koch Karel T. , Wykrzykowska Joanna J. , Henriques José P. , de Winter Robbert J. , Piek Jan J. 
Published: November 2016

Background—
The Navvus pressure sensor–equipped microcatheter allows to measure functional stenosis severity over a work-horse guidewire and is used as a more feasible alternative to regular sensor-equipped wires. However, Navvus is larger in diameter than contemporary sensor-equipped guidewires and may, thereby, influence functional measurements. The present study evaluates the hemodynamic influence of the Navvus microcatheter.

Methods and Results—

In patients with intermediate coronary stenosis, coronary pressure and flow velocity were measured using a dual sensor–equipped guidewire before and after introduction of Navvus. Patients were randomized to microcatheter-first or guidewire-first measurement. The primary end point was the difference in hyperemic stenosis resistance index between measurements before and after introduction of Navvus. Measurements were completed in 28 patients (28 stenoses). Mean hyperemic stenosis resistance was 0.37±0.19 Hg/cm/s for wire-only assessment and 0.48±0.26 Hg/cm/s after Navvus introduction (
P
<0.001). Bland–Altman analysis documented a mean bias of +0.11 Hg/cm/s (limits of agreement: −0.13 to 0.36), proportional to mean hyperemic stenosis resistance (Spearman ρ =0.61;
P
=0.001). Passing–Bablok analysis revealed absence of a constant difference but significant proportional difference between the methods. Mean fractional flow reserve was 0.86±0.06 for wire-only assessment and 0.82±0.07 after Navvus introduction (
P
<0.001). Bland–Altman analysis documented a mean bias of −0.033 (limits of agreement: −0.09 to 0.03), proportional to mean fractional flow reserve (Spearman ρ =0.40;
P
=0.036). Passing–Bablok analysis revealed significant constant and proportional differences between methods. Similar results were documented for resting indices of stenosis severity.

Conclusions—
Introduction of the Navvus microcatheter leads to clinically relevant stenosis severity overestimation in intermediate stenosis.
Coagulation Testing in Acute Ischemic Stroke Patients Taking Non–Vitamin K Antagonist Oral Anticoagulants
Authors: Purrucker Jan C. , Haas Kirsten , Rizos Timolaos , Khan Shujah , Poli Sven , Kraft Peter , Kleinschnitz Christoph , Dziewas Rainer , Binder Andreas , Palm Frederick , Jander Sebastian , Soda Hassan , Heuschmann Peter U. , Veltkamp Roland , Dichgans M. , Gröschel K. , Eicke M. , Ertl M. , Hennerici M. G. , Hobohm C. , Höhle T. , Jüttler E. , Khaw A. , Kraft A. , Köhrmann M. , Meisel F. , Neumann-Haefelin T. , Opherk C. , Röther J. , Schmid E. , Seidel G. , Tanislav C. , Thomalla G. , Wartenberg K. , Weimar C. 
Published: November 2016

Background and Purpose—
In patients who present with acute ischemic stroke while on treatment with non–vitamin K antagonist oral anticoagulants (NOACs), coagulation testing is necessary to confirm the eligibility for thrombolytic therapy. We evaluated the current use of coagulation testing in routine clinical practice in patients who were on NOAC treatment at the time of acute ischemic stroke.

Methods—
Prospective multicenter observational RASUNOA registry (Registry of Acute Stroke Under New Oral Anticoagulants; February 2012–2015). Results of locally performed nonspecific (international normalized ratio, activated partial thromboplastin time, and thrombin time) and specific (antifactor Xa tests, hemoclot assay) coagulation tests were documented. The implications of test results for thrombolysis decision-making were explored.

Results—
In the 290 patients enrolled, nonspecific coagulation tests were performed in ≥95% and specific coagulation tests in 26.9% of patients. Normal values of activated partial thromboplastin time and international normalized ratio did not reliably rule out peak drug levels at the time of the diagnostic tests (false-negative rates 11%–44% [95% confidence interval 1%–69%]). Twelve percent of patients apparently failed to take the prescribed NOAC prior to the acute event. Only 5.7% (9/159) of patients in the 4.5-hour time window received thrombolysis, and NOAC treatment was documented as main reason for not administering thrombolysis in 52.7% (79/150) of patients.

Conclusions—
NOAC treatment currently poses a significant barrier to thrombolysis in ischemic stroke. Because nonspecific coagulation test results within normal range have a high false-negative rate for detection of relevant drug concentrations, rapid drug-specific tests for thrombolysis decision-making should be established.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01850797.
Global Enhancement but Local Suppression in Feature-based Attention
Authors: Forschack Norman , Andersen Søren K. , Müller Matthias M. 
Published: November 2016

Abstract
A key property of feature-based attention is global facilitation of the attended feature throughout the visual field. Previously, we presented superimposed red and blue randomly moving dot kinematograms (RDKs) flickering at a different frequency each to elicit frequency-specific steady-state visual evoked potentials (SSVEPs) that allowed us to analyze neural dynamics in early visual cortex when participants shifted attention to one of the two colors. Results showed amplification of the attended and suppression of the unattended color as measured by SSVEP amplitudes. Here, we tested whether the suppression of the unattended color also operates globally. To this end, we presented superimposed flickering red and blue RDKs in the center of a screen and a red and blue RDK in the left and right periphery, respectively, also flickering at different frequencies. Participants shifted attention to one color of the superimposed RDKs in the center to discriminate coherent motion events in the attended from the unattended color RDK, whereas the peripheral RDKs were task irrelevant. SSVEP amplitudes elicited by the centrally presented RDKs confirmed the previous findings of amplification and suppression. For peripherally located RDKs, we found the expected SSVEP amplitude increase, relative to precue baseline when color matched the one of the centrally attended RDK. We found no reduction in SSVEP amplitude relative to precue baseline, when the peripheral color matched the unattended one of the central RDK, indicating that, while facilitation in feature-based attention operates globally, suppression seems to be linked to the location of focused attention.
A Multialgorithm Reanalysis-Based Freezing-Precipitation Dataset for Climate Studies in the South-Central United States
Authors: Mullens Esther D. , McPherson Renee 
Published: November 2016

AbstractFreezing precipitation, including freezing rain, freezing drizzle, and ice pellets, presents substantial hazards to transportation, energy, and infrastructure. Most quantitative climate-length (>30 years) datasets for freezing precipitation are obtained from in situ instrumentation, such as National Weather Service (NWS) automated observing systems or the NWS Cooperative Observer Program, that can be spatially and temporally inhomogeneous. This work investigates whether the 32-km North American Regional Reanalysis (NARR) is a viable dataset for developing a comprehensive and high-resolution spatially gridded dataset for freezing precipitation and its associated meteorological environment, with a focus on the south-central United States. NARR includes categorical precipitation type as a variable; to permit a translatable method across other gridded multidimensional reanalyses, however, a multialgorithm approach is also used to extract environmental conditions, event counts, and liquid water equivalent (LWE) for freezing precipitation, defined as total accumulated freezing rain and ice pellets. The resulting datasets are evaluated spatially and temporally against hourly and daily event counts and LWE compiled from 13 first-order NWS stations, the National Centers for Environmental Information Storm Data product, and “meteorological phenomena identification near the ground” (mPING) observations. Very good statistical agreement is evident for many of the station sites, and NARR is able, in most cases, to reproduce years with heavy-ice events and the spatial extent of such events. Climatological freezing precipitation tends to be underestimated in the western subdomain and overestimated in the south. It is concluded that the derived datasets could be a useful tool for climatological research and hazard analysis, with some caveats.
Droplet Concentration and Spectral Broadening in Southeast Pacific Stratocumulus Clouds
Authors: Snider Jefferson R. , Leon David , Wang Zhien 
Published: November 2016

Abstract
Several airborne field experiments have been conducted to verify model descriptions of cloud droplet activation. Measurements of cloud condensation nuclei and updraft are inputs to a parcel model that predicts droplet concentration and droplet size distributions (spectra). Experiments conducted within cumulus clouds have yielded the most robust agreement between model and observation. Investigations of stratocumulus clouds are more varied, in part because of the difficulty of gauging the effects of entrainment and drizzle on droplet concentration and spectra. Airborne lidar is used here to supplement the approach used in prior studies of droplet activation in stratocumulus clouds.
A model verification study was conducted using data acquired during the Southern Hemispheric VAMOS Ocean–Cloud–Aerosol–Land Study Regional Experiment. Consistency between observed and modeled droplet concentrations is achieved, but only after accounting for the effects of entrainment and drizzle on concentrations produced by droplet activation. In addition, predicted spectral dispersions are 74% of the measured dispersions following correction for instrument broadening. This result is consistent with the conjecture that differential activation (at cloud base) and internal mixing (i.e., mixing without entrainment) are important drivers of true spectral broadening.
Lidar Method to Estimate Emission Rates from Extended Sources
Authors: Willis William B. , Eichinger William E. , Prueger John H. , Hapeman Cathleen J. , Li Hong , Buser Michael D. , Hatfield Jerry L. , Wanjura John D. , Holt Gregory A. , Torrents Alba , Plenner Sean J. , Clarida Warren , Browne Stephen D. , Downey Peter M. , Yao Qi 
Published: November 2016

AbstractPollutant emissions to the atmosphere commonly derive from nonpoint sources that are extended in space. Such sources may contain area, volume, line, or a combination of emission types. Currently, point measurements, often combined with models, are the primary means by which atmospheric emission rates are estimated from extended sources. Point measurement arrays often lack in spatial and temporal resolution and accuracy. In recent years, lidar has supplemented point measurements in agricultural research by sampling spatial ensembles nearly instantaneously. Here, a methodology using backscatter data from an elastic scanning lidar is presented to estimate emission rates from extended sources. To demonstrate the approach, a known amount of particulate matter was released upwind of a vegetative environmental buffer, a barrier designed to intercept emissions from animal production facilities. The emission rate was estimated downwind of the buffer, and the buffer capture efficiency (percentage of particles captured) was calculated. Efficiencies ranged from 21% to 74% and agree with the ranges previously published. A comprehensive uncertainty analysis of the lidar methodology was performed, revealing an uncertainty of 20% in the emission rate estimate; suggestions for significantly reducing this uncertainty in future studies are made. The methodology introduced here is demonstrated by estimating the efficiency of a vegetative buffer, but it can also be applied to any extended emission source for which point samples are inadequate, such as roads, animal feedlots, and cotton gin operations. It can also be applied to any pollutant for which a lidar system is configured, such as particulate matter, carbon dioxide, and ammonia.
The Fragility of Statistically Significant Findings From Randomized Trials in Sports Surgery: A Systematic Survey
Authors: Khan Moin , Evaniew Nathan , Gichuru Mark , Habib Anthony , Ayeni Olufemi R. , Bedi Asheesh , Walsh Michael , Devereaux P.J. , Bhandari Mohit 
Published: November 2016

Background:High-quality, evidence-based orthopaedic care relies on the generation and translation of robust research evidence. The Fragility Index is a novel method for evaluating the robustness of statistically significant findings from randomized controlled trials (RCTs). It is defined as the minimum number of patients in 1 arm of a trial that would have to change status from a nonevent to an event to alter the results of the trial from statistically significant to nonsignificant.Purpose:To calculate the Fragility Index of statistically significant results from clinical trials in sports medicine and arthroscopic surgery to characterize the robustness of the RCTs in these fields.Methods:A search was conducted in Medline, EMBASE, and PubMed for RCTs related to sports medicine and arthroscopic surgery from January 1, 2005, to October 30, 2015. Two reviewers independently assessed titles and abstracts for study eligibility, performed data extraction, and assessed risk of bias. The Fragility Index was calculated using the Fisher exact test for all statistically significant dichotomous outcomes from parallel-group RCTs. Bivariate correlation was performed to evaluate associations between the Fragility Index and trial characteristics.Results:A total of 48 RCTs were included. The median sample size was 64 (interquartile range [IQR], 48.5-89.5), and the median total number of outcome events was 19 (IQR, 10-27). The median Fragility Index was 2 (IQR, 1-2.8), meaning that changing 2 patients from a nonevent to an event in the treatment arm changed the result to a statistically nonsignificant result, or P ≥ .05.Conclusion:Most statistically significant RCTs in sports medicine and arthroscopic surgery are not robust because their statistical significance can be reversed by changing the outcome status on only a few patients in 1 treatment group. Future work is required to determine whether routine reporting of the Fragility Index enhances clinicians’ ability to detect trial results that should be viewed cautiously.
Investigating Spatial Dependence and Spatial Spillovers in African Agricultural Total Factor Productivity Growth
Authors: Lukongo Onyumbe E. , Rezek Jon P. 
Published: November 2016

This study improves our understanding of the spatial dependence and spillovers of war on the agricultural sector productivity. The results provided here represent the first attempt in the literature to identify the total factor productivity impacts of war in Africa. War disrupts the agricultural sector in the affected country and its borders through loss of capitals, deaths of experienced farmers, disease, insecurity, and dislocation. A war may reduce productivity in a given country—a reduction of agricultural productivity by 0.41% and 0.40% in Congo and Angola, respectively. But its real effects, which are overlooked by alternative modeling strategies, are larger. JEL Classifications: C21, O11, O43, D24
The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease
Authors: Amara Ahmed , Mrad Meriem , Sayeh Aicha , Lahideb Dhaker , Layouni Samy , Haggui Abdeddayem , Fekih-Mrissa Najiba , Haouala Habib , Nsiri Brahim 
Published: November 2016

Background: Coronary artery disease (CAD), also known as atherosclerotic heart disease, is a leading cause of mortality and morbidity throughout the world. The role of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene in the etiology of CAD remains to be more completely clarified. The aim of this study was to determine the role of the ACE I/D polymorphism in patients with CAD and to study the association together with traditional risk factors in assessing the risk of CAD. Methods: Our study population included 145 Tunisian patients with symptomatic CAD and a control group of 300 people matched for age and sex. All participants in the study were genotyped for the ACE I/D polymorphisms obtained by polymerase chain reaction amplification on genomic DNA. Results: Our analysis showed that the ACE D allele frequency ( P < 10−3; odds ratio [OR] = 5.2; 95% confidence interval [CI] = 3.6-7.6) and DD genotype ( P < 10−3; OR = 6.8; 95% CI = 4.4-10) are significantly more prevalent among patients with CAD than in controls and may be predisposing to CAD. We further found that the risk of CAD is greatly potentiated by several concomitant risk factors (smoking, diabetes, hypertension, dyslipidemia, and a family history of CAD). Conclusion: The ACE D allele may be predictive in individuals who may be at risk of developing CAD. Further investigations of these polymorphisms and their possible synergisms with traditional risk factors for CAD could help to ascertain better predictability for CAD susceptibility.
Impact of Donor Recipient Gender and Race Mismatch on Graft Outcomes in Patients With End-Stage Liver Disease Undergoing Liver Transplantation
Authors: Zhang Yefei 
Published: November 2016

Context: The discrepancy between donor supply and organ demand increased the possibility of gender and race mismatch between the donors and recipients. However, the findings of their impact on graft and patient survival are outdated and mixed. Objective: To estimate the effects of gender and race mismatch on graft survival and patient survival among adult patients (18 years and older) with end-stage liver disease. Design: A total of 38 768 patients undergoing liver transplant between 2002 and 2011 were identified from United Network for Organ Sharing database. Kaplan-Meier curves, log-rank tests, and Cox proportional hazard regressions with backward elimination adopting a marginal approach with a working independence assumption and stratification on recipient hepatitis C virus status were used. Main Outcome Measures: Posttransplantation graft survival and patient survival. Results: Both gender mismatch (hazard ratio [HR]: 1.14, 95% confidence interval [CI]: 1.09-1.12) and race mismatch (HR 1.08, 95%C: 1.04-1.12) had significantly adverse effects on graft survival and patient survival after controlling for other factors, especially among hepatitis C-positive female recipients with male donors (HR 1.13, 95%CI 1.03-1.24), black recipients with white donors (1.39, 1.29-1.49) or Hispanic donors (HR 1.48, 95%CI 1.27-1.72), and these effects were even worse among hepatitis C-positive recipients. Conclusion: Gender and race mismatch between donors and recipients adversely affected graft survival and patient survival among adult patients with end-stage liver disease, both independently and after the adjustment for other factors. Future research is recommended to explore other factors such as new model for end-stage liver disease sharing policy change and disparities in access to waiting-list or transplantation.
Crosstalk between microRNA-122 and FOX family genes in HepG2 cells
Authors: Kumar Subodh , Batra Ankita , Kanthaje Shruthi , Ghosh Sujata , Chakraborti Anuradha 
Published: November 2016

MicroRNA-122 (miR-122) is liver specific and plays an important role in physiology as well as diseases including hepatocellular carcinoma (HCC). Downregulation of miR-122 in HCC modulates apoptosis. Similarly, the putative targets of miR-122, the forkhead box (FOX) family genes also play an important role in the regulation of apoptosis. Hence, an interplay between miR-122 and FOX family genes has been explored in this study. Initially, an augmentation of apoptosis was noticed in HepG2 cells after transfection with miR-122. Further, the predicted miR-122 targets, the FOX family genes ( FOXM1b, FOXP1, and FOXO4) were selected via in silico analysis based on their role in apoptosis. We checked the expression of all these genes at transcript level after the transfection of miR-122 and found that the relative expression of FOXP1 and FOXM1b was significantly downregulated (p < 0.005) and that of FOXO4 was upregulated (p < 0.005). Thus, the finding indicates deregulation of these FOX genes as a result of miR-122 augmentation might be involved in the modulation of apoptosis. Impact Statement Here, we have investigated the crosstalk between microRNA-122 (miR-122) and selective FOX family genes in HepG2 cells. miR-122 is a prominent miRNA in liver and has been reported to be downregulated in hepatocellular carcinoma (HCC). It has been speculated that diminished level of miR-122 during HCC might be one of the reasons for tumor progression. However, the exact molecular interactions are not clear yet. This study unravels one of the molecular mechanisms of miR-122 through which it might impact the tumorigenesis of HCC.
Secular pattern of aneurismal rupture with the lunar cycle and season
Authors: Banfield Jillian C , Abdolell Mohamed , Shankar Jai S 
Published: November 2016

Background The lunar cycle and seasons may be associated with rates of rupture of intracranial aneurysms, but the literature is mixed. Studies of the association between the lunar cycle and rates of aneurysm rupture used the eight qualitative moon phases. The purpose of this study was to assess any association of aneurysm rupture with the lunar cycle and with the season. Materials and methods We retrospectively reviewed all cases of subarachnoid haemorrhage secondary to ruptured intracranial aneurysm treated with endovascular coiling in our institution over a 10-year period. We included only cases with a known rupture date. We used the degree of illumination of the moon to quantitatively code the lunar cycle. Results A total of 212 cases were included in our analyses. The odds of aneurysm rupture were significantly greater ( p < 0.001) when the moon was least (new moon) and most (full moon) illuminated, as compared to the middle of the lunar cycle. The odds of rupture tended to be higher ( p = 0.059) in the summer, compared to autumn. Conclusions The odds of aneurysm rupture were greater when the moon was least illuminated (new moon) and most illuminated (full moon), compared to the middle of the lunar cycle.