bluuebunny/crossref_metadata_2025_split huggingface dataset:
Externally visible thrombus partially predicts internal thrombus deposition in extracorporeal membrane oxygenators
Authors: Evans Charles F. , Li Tieluo , Mishra Vikas , Pratt Diana L. , Mohammed Isa S.K. , Kon Zachary N. , Griffith Bartley P. 
Published: November 2016

Aim: We sought to quantify the location and volume of thrombus in used hollow-fiber membrane oxygenators and correlate the volume of thrombus with patient demographics, flow characteristics and anticoagulation parameters. Methods: Hollow-fiber membrane oxygenators (Quadrox D, Maquet, Rastatt, Germany) were collected after clinical use in ECMO circuits and divided into sections. Each section was digitally imaged and analyzed using ImageJ software. The location and total volume (cm3) of thrombus was calculated for different sections. In an effort to predict thrombus formation, we correlated thrombus volume with possible aggravating and mitigating variables. Results: We collected 41 oxygenators from 27 patients. Twenty-seven (66%) were configured in the veno-venous mode and 14 (34%) in the veno-arterial mode. The median duration of use was 131 hours (interquartile range 61–214 hours). Eighteen (44%) were removed when the patient recovered, six (15%) were removed after withdrawal of care and seventeen (41%) were exchanged. The median volume of thrombus was 11.4 cm3 (interquartile range 2.2–44.5 cm3). Conclusions: A multivariable linear regression model suggested that the combination of median flow, configuration of ECMO and visible thrombus partially predicted internal thrombus volume (adjusted R2=0.39).
Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes
Authors: Titchenal Matthew R. , Chu Constance R. , Erhart-Hledik Jennifer C. , Andriacchi Thomas P. 
Published: November 2016

Background: Altered knee kinematics after anterior cruciate ligament injury and reconstruction (ACLR) have been implicated in the development of posttraumatic osteoarthritis (PTOA), leading to poor long-term clinical outcomes. Purpose: This study was conducted to determine (1) whether the average knee center of rotation (KCOR), a multidimensional metric of knee kinematics, of the ACL-reconstructed knee during walking differs from that of the uninjured contralateral knee; (2) whether KCOR changes between 2 and 4 years after surgery; and (3) whether early KCOR changes predict patient-reported outcomes 8 years after ACLR. Study Design: Descriptive laboratory study. Methods: Twenty-six human participants underwent gait analysis with calculation of bilateral KCOR during walking at 2 and 4 years after unilateral ACLR. Knee injury and Osteoarthritis Outcome Score (KOOS) and Lysholm score results were collected at 2, 4, and 8 years after ACLR in 13 of these participants. Results: The ACL-reconstructed knee showed greater medial compartment motion because of pivoting about a more lateral KCOR ( P = .03) than the contralateral knee at 2 years. KCOR became less lateral over time ( P = .047), with values approaching those of the uninjured knee by 4 years ( P = .55). KCOR was also more anterior in the ACL-reconstructed knee at 2 years ( P = .02). Between 2 and 4 years, KCOR moved posteriorly in 16 (62%) and anteriorly in 10 (38%) participants. Increasing the anterior position of KCOR in the ACL-reconstructed knee from 2 to 4 years correlated with worsening clinical outcomes at 4 years (KOOS–Quality of Life, R2 = 0.172) and more strongly at 8 years (Lysholm score, R2 = 0.41; KOOS-Pain, R2 = 0.37; KOOS-Symptoms, R2 = 0.58; and KOOS–Quality of Life, R2 = 0.50). Conclusion: The observed changes to KCOR during walking between 2 and 4 years after ACLR show progressive improvement toward kinematic symmetry over the 2-year follow-up. The correlation between increasingly abnormal kinematics and worsening clinical outcomes years later in a subset of participants provides a potential explanation for the incidence of PTOA after ACLR.
Brazilian Immigrant Mothers’ Beliefs and Practices Related to Infant Feeding: A Qualitative Study
Authors: Lindsay Ana Cristina , Wallington Sherrie F. , Greaney Mary L. , Hasselman Maria Helena , Tavares Machado Marcia Maria , Mezzavilla Raquel S. 
Published: November 2016

Background: Exclusive breastfeeding for the first 6 months of life and timely introduction of appropriate solid foods are important determinants of weight status in infancy and later life stages. Disparities in obesity rates among young children suggest that maternal feeding practices during the first 2 years of life may contribute to these disparities. Brazilians are a growing immigrant group in the United States, yet little research has focused on parental beliefs and behaviors affecting the health of Brazilian immigrant children in the United States. Research aim: This study aimed to explore beliefs and infant-feeding practices of Brazilian immigrant mothers in the United States. Methods: Focus group discussions were conducted with Brazilian immigrant mothers. Transcripts were analyzed using thematic analysis and themes categorized using the socioecological model. Results: Twenty-nine immigrant Brazilian mothers participated in the study. Analyses revealed that all participants breastfed their infants. The majority initiated breastfeeding soon after childbirth. However, most mothers did not exclusively breastfeed. They used formula and human milk concomitantly. Family and culture influenced mothers’ infant-feeding beliefs and practices in early introduction of solid foods. Conclusion: As the number of children in the United States growing up in families of immigrant parents increases, understanding influences on Brazilian immigrant mothers’ infant-feeding practices will be important to the development of effective interventions to promote healthy infant feeding and weight status among Brazilian children. Interventions designed for Brazilian immigrant families should incorporate an understanding of social context, family, and cultural factors to develop health promotion messages tailored to the needs of this ethnic group.
Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial): Rationale and study design
Authors: Geisler Tobias , Poli Sven , Meisner Christoph , Schreieck Juergen , Zuern Christine S , Nägele Thomas , Brachmann Johannes , Jung Werner , Gahn Georg , Schmid Elisabeth , Bäezner Hansjörg , Keller Timea , Petzold Gabor C , Schrickel Jan-Wilko , Liman Jan , Wachter Rolf , Schön Frauke , Schabet Martin , Lindner Alfred , Ludolph Albert C , Kimmig Hubert , Jander Sebastian , Schlegel Uwe , Gawaz Meinrad , Ziemann Ulf 
Published: November 2016

Rationale Optimal secondary prevention of embolic stroke of undetermined source is not established. The current standard in these patients is acetylsalicylic acid, despite high prevalence of yet undetected paroxysmal atrial fibrillation. Aim The ATTICUS randomized trial is designed to determine whether the factor Xa inhibitor apixaban administered within 7 days after embolic stroke of undetermined source, is superior to acetylsalicylic acid for prevention of new ischemic lesions documented by brain magnetic resonance imaging within 12 months after index stroke. Design Prospective, randomized, blinded, parallel-group, open-label, German multicenter phase III trial in approximately 500 patients with embolic stroke of undetermined source. A key inclusion criterion is the presence or the planned implantation of an insertable cardiac monitor. Patients are 1:1 randomized to apixaban or acetylsalicylic acid and treated for a 12-month period. It is an event-driven trial aiming for core-lab adjudicated primary outcome events. Study outcomes The primary outcome is the occurrence of at least one new ischemic lesion identified by axial T2-weighted FLAIR magnetic resonance imaging and/or axial DWI magnetic resonance imaging at 12 months when compared with the baseline magnetic resonance imaging. Key secondary outcomes are the combination of recurrent ischemic strokes, hemorrhagic strokes, systemic embolism; combination of MACE including recurrent stroke, myocardial infarction, and cardiovascular death and combination of major and clinically relevant non-major bleeding defined according to ISTH, and change of cognitive function and quality of life (EQ-5D, Stroke Impact Scale). Discussion Embolic stroke of undetermined source is caused by embolic disease and associated with a high risk of recurrent ischemic strokes and clinically silent cerebral ischemic lesions. ATTICUS will investigate the impact of atrial fibrillation detected by insertable cardiac monitor and the effects of early anticoagulation with apixaban compared with antiplatelet therapy with acetylsalicylic acid on the incidence of new ischemic lesion after embolic stroke of undetermined source.
Investigation of Eligible Picture Categories for Use as Environmental Cues in Dementia-Sensitive Environments
Authors: Motzek Tom , Bueter Kathrin , Marquardt Gesine 
Published: November 2016

Objectives: Environmental cues, such as pictures, could be helpful in improving room-finding and wayfinding abilities among older patients. The aim of this study was to identify picture categories that are preferred and easily remembered by older patients and cognitively impaired patients and which therefore might be suitable for use as environmental cues in acute care settings. Methods: Twelve pictures were presented to a sample of older patients ( n = 37). The pictures represented different categories: familiarity (familiar vs. unfamiliar), type of shot (close-up vs. wide shot), and picture content (nature vs. animal vs. urban). We tested the patients’ votes of preference and abilities to identify and immediately recall pictures. Cognitively impaired patients ( n = 14) were assessed by the abbreviated mental test and the mini mental state examination and were compared with patients without cognitive impairments ( n = 23) using a repeated measures analysis of variance. Results: The results showed a main effect of familiarity on positive vote and recall of pictures. The absence of interaction effects of familiarity and group indicated an overall impact of familiarity on the sample. Within cognitively impaired patients, a significant difference in recall of picture content between urban (20%) and animal (9%) was found. Conclusions: Pictures, which patients were able to relate to in terms of familiarity and the characteristics urban and nature, seem to be suitable for use as environmental cues. Besides functioning as such, we assume, based on literature, that pictures could further enhance the ambiance or serve as prompts for communication and interaction.
Biomechanical Comparison of Fixation Devices for First Metatarsocuneiform Joint Arthrodesis
Authors: Knutsen Ashleen R. , Fleming John F. , Ebramzadeh Edward , Ho Nathan C. , Warganich Tibor , Harris Thomas G. , Sangiorgio Sophia N. 
Published: November 2016

Common surgical treatment of first tarsal-metatarsal arthritis is by first metatarsocuneiform joint arthrodesis. While crossed-screw and locking plate fixation are the most widely used methods, a novel construct was designed to alleviate soft tissue irritation while still providing stable fixation. Using anatomic first metatarsal and medial cuneiform composites, we compared 3 arthrodesis implants (crossed-screw, dorsal locking plate, and IO Fix) under 2 cyclic bending loading scenarios (cantilever and 4-point bending). Additionally, the optimal orientation (plantar-dorsal or dorsal-plantar) of the IO Fix construct was determined. Failure load, diastasis, joint space angle, and axial and angular stiffness were determined. Both crossed-screw fixation and the IO Fix constructs experienced significantly higher failure loads than the dorsal locking plate during both loading scenarios. Additionally, they had lower plantar diastasis and joint space angle at failure than the plate. Moreover, the plantar-dorsal IO Fix construct was significantly stiffer than the crossed-screw during cantilever bending. Finally, the plantar-dorsal orientation of the IO Fix device had higher failure load and lower diastasis and angle at failure than in the dorsal-plantar orientation. The results suggest that the IO Fix system can reduce motion at the interfragmentary site and ensure compression for healing comparable to that of the crossed-screw fixation. Levels of Evidence: Level V: Bench testing
Hematogenous Calcaneal Osteomyelitis in Children
Authors: Mooney Megan L. , Haidet Kirk , Liu Jiayong , Ebraheim Nabil A. 
Published: November 2016

Osteomyelitis in children commonly affects long bones such as the femur, tibia, and humerus. There have been relatively few documented studies of osteomyelitis at unusual locations, such as the calcaneus. The objective of this study is to systematically review information on the diagnostic and treatment methods of calcaneal osteomyelitis as well as associated complications. Methods included research database searches using primarily PubMed and EMBASE databases. Results of the review show no clear approach to diagnosis and treatment of calcaneal osteomyelitis in children. Clinical presentation of refusal to bear weight was the most common clinical symptom. Magnetic resonance imaging was 100% diagnostic in studies that used this modality, compared with X-rays, which were 14%-71.4% diagnostic. Blood cultures were diagnostic in 27% to 55% of cases, and erythrocyte sedimentation rate was elevated in 79% to 97% of cases. Methicillin-sensitive Staphylococcus aureus was the most common cultured organism. Treatment involved either antibiotics alone or in combination with surgical debridement/evacuation. Penicillin, penicillin derivatives, cephalosporins, clindamycin, and chloramphenicol were the most commonly used antibiotics, with duration varying from 5 days to 10 weeks. The most common complication was recurrent osteomyelitis. Levels of Evidence: III
The Effect of Suture Anchor Insertion Angle on Calcaneus Pullout Strength: Challenging the Deadman’s Angle
Authors: Weiss William M. , Saucedo Ramon P. , Robinson John D. , Lo Chung-Chieh Jason , Morris Randal P. , Panchbhavi Vinod K. 
Published: November 2016

Background. Refractory cases of Achilles tendinopathy amenable to surgery may include reattachment of the tendon using suture anchors. However, there is paucity of information describing the optimal insertion angle to maximize the tendon footprint and anchor stability in the calcaneus. The purpose of this investigation is to compare the fixation strength of suture anchors inserted at 90° and 45° (the Deadman’s angle) relative to the primary compressive trabeculae of the calcaneus. Methods. A total of 12 matched pairs of adult cadaveric calcanei were excised and potted to approximate their alignment in vivo. Each pair was implanted with 5.5-mm bioabsorbable suture anchors placed either perpendicular (90°) or oblique (45°) to the primary compressive trabeculae. A tensile load was applied until failure of anchor fixation. Differences in failure load and stiffness between anchor fixation angles were determined by paired t-tests. Results. No significant differences were detected between perpendicular and oblique suture anchor insertion relative to primary compressive trabeculae in terms of load to failure or stiffness. Conclusion. This investigation suggests that the fixation strength of suture anchors inserted perpendicular to the primary compression trabeculae and at the Deadman’s angle are possibly comparable. Levels of Evidence: Biomechanical comparison study
Repair of Chronic Achilles Ruptures Has a High Incidence of Venous Thromboembolism
Authors: Bullock Mark J. , DeCarbo William T. , Hofbauer Mark H. , Thun Joshua D. 
Published: November 2016

Background. Despite the low incidence of deep vein thrombosis (DVT) in foot and ankle surgery, some authors report a high incidence of symptomatic DVT following Achilles tendon rupture. The purpose of this study was to identify DVT risk factors inherent to Achilles tendon repair to determine which patients may benefit from prophylaxis. Methods. One hundred and thirteen patient charts were reviewed following elective and nonelective Achilles tendon repair. For elective repair of insertional or noninsertional Achilles tendinopathy, parameters examined included lateral versus prone positioning and the presence versus absence of a flexor hallucis longus transfer. For nonelective repair, acute Achilles tendon ruptures were compared to chronic Achilles tendon ruptures. Results. Of 113 Achilles tendon repairs, 3 venous thromboembolism (VTE) events (2.65%) occurred including 2 pulmonary emboli (1.77%). Seventeen of these repairs were chronic Achilles tendon ruptures, and all 3 VTE events (17.6%) occurred within this subgroup. Elevated body mass index was associated with VTE in patients with chronic Achilles ruptures although this did not reach significance ( P = .064). No VTE events were reported after repair of 28 acute tendon ruptures or after 68 elective repairs of tendinopathy. Two patients with misdiagnosed partial Achilles tendon tears were excluded because they experienced a VTE event 3 weeks and 5 weeks after injury, prior to surgery. Conclusion. In our retrospective review, chronic Achilles ruptures had a statistically significant higher incidence of VTE compared with acute Achilles ruptures ( P = .048) or elective repair ( P = .0069). Pharmaceutical anticoagulation may be considered for repair of chronic ruptures. Repair of acute ruptures and elective repair may not warrant routine prophylaxis due to a lower incidence of VTE. Levels of Evidence: Prognostic, Level III: Case Control Study
A review of design characteristics of cognitive behavioral therapy-informed behavioral intervention technologies for youth with depression and anxiety
Authors: Stiles-Shields Colleen , Ho Joyce , Mohr David C 
Published: November 2016

Objective Cognitive behavioral therapy (CBT) has the strongest evidence base for the prevention and treatment of depression and anxiety in youth. Behavioral intervention technologies (BITs) provide an opportunity to overcome access barriers to traditional delivery of CBT. The present review evaluates the design characteristics of CBT-informed BITs for depression and anxiety designed for and tested with youth. Methods A state-of-the-art review of three library databases (PubMed, Scopus, and Web of Science) was conducted to identify papers that evaluated the use of CBT-informed BITs for the prevention and/or treatment of depression and anxiety among youth. Narrative results of design characteristics were organized using the BIT model, which provides a framework for design and evaluation. Results 219 unique results were retrieved through the search. After review, 14 papers (4 prevention and 10 treatment) met the selection criteria. A broad diversity occurred in reporting the design and methodology of CBT delivered to youth through BITs. Psychoeducation was overwhelmingly utilized as the primary change strategy throughout the interventions, with a heavy use of content delivery elements and linear workflows. The reporting of sample characteristics was minimal and varied. Conclusions Providing psychoeducation via content delivery was the most utilized BIT change strategy in the interventions, likely limiting the use of multiple BIT elements or flexible workflows. While characterizations could be inferred from the current reports, the high level of variability in reporting is problematic. Generalizability becomes increasingly more difficult to carry out effectively without clear descriptions of the design for evaluated BITs.
The Men’s Safer Sex Trial: A feasibility randomised controlled trial of an interactive digital intervention to increase condom use in men
Authors: Bailey Julia V , Webster Rosie , Griffin Mark , Freemantle Nick , Hunter Rachael , Rait Greta , Estcourt Claudia , Anderson Jane , Gerressu Makeda , Stephenson Judith , Michie Susan , Murray Elizabeth 
Published: November 2016

Objectives We aimed to determine the feasibility of an online randomised controlled trial (RCT) of the Men’s Safer Sex website, measuring condom use and sexually transmitted infection (STI). Methods For this study 159 men aged ≥16 with female sexual partners and recent condomless sex or suspected STI were recruited from three UK sexual health clinics. Participants were randomised to the intervention website plus usual clinic care ( n = 84), or usual clinic care only ( n = 75). Online outcome data were solicited at 3, 6, and 12 months. Results Men were enrolled via tablet computers in clinic waiting rooms. Software errors and clinic Wi-Fi access presented significant challenges, and online questionnaire response rates were poor (36% at 3 months with a £10 voucher; 50% at 12 months with £30). Clinical records (for STI diagnoses) were located for 94% of participants. Some 37% of the intervention group did not see the intervention website ( n = 31/84), and (as expected) there was no detectable difference in condomless sex with female partners (IRR = 1.01, 95% CI 0.52 to 1.96). New acute STI diagnoses were recorded for 8.8% (7/80) of the intervention group, and 13.0% (9/69) of the control group over 12 months (IRR = 0.75, 95% CI 0.29 to 1.90). Conclusion It is likely to be feasible to conduct a future large-scale RCT to assess the impact of an online intervention using clinic STI diagnoses as a primary outcome. However, practical and technical challenges need to be addressed before the potential of digital media interventions can be realised in sexual health settings. Trial registration number: ISRCTN18649610
The Department of Posts in Financial Inclusion of the Unorganized Sector: A Case Study of SSP Disbursements in Visakhapatnam
Authors: Vasudha T. , Padmaraja Usha M.  , Vennam Upender , Sampath Sharda 
Published: November 2016

The purpose of this research is to assess the effectiveness of the role played by the Department of Posts (DoP) in financial inclusion of the unorganized sector. It examines, by studying the issues in disbursement of Social Security Pensions (SSPs) in a region, the strengths, weaknesses and opportunities that the DoP has and the threats it could face. The empirical study is confined to only one initiative of DoP, that is, SSP disbursements in Visakhapatnam district of Andhra Pradesh. The primary data was collected during the transition period when DoP was into SSP disbursements in urban as well as rural areas of Visakhapatnam on an experimental basis (February–April, 2015). Altogether eight hypotheses were tested for significance, based on the data collected through observation, interviews, survey and literature review. The sample for data collection consisted of DoP employees (from frontline to top management), representatives of local governing bodies in villages and SSP beneficiaries. The SWOT analysis of DoP helped in identifying issues in disbursements and perceptions (of both beneficiaries and DoP employees). The results show that DoP has been successful in achieving the first level of financial inclusion and has to work towards achieving the second level through collaborative partnerships. Several suggestions and recommendations have been made for both DoP and policy-makers, which would help DoP in overcoming the challenges that it faces in financial inclusion. It is suggested that by looking at the bigger picture beyond disbursements, that is, financial inclusion of the bottom-of-the-pyramid customers, DoP will be able to emerge as a major player in the economic growth of the country.