bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of voice outcomes and complication rates in patients undergoing injection laryngoplasty performed under local versus general anaesthesia: an Adelaide voice specialist's experience
Authors: Chandran D , Woods C , Ullah S , Ooi E , Athanasiadis T 
Published: February 2017

AbstractObjective:To compare clinical outcomes and complication rates in patients undergoing injection laryngoplasty performed under local versus general anaesthesia.Methods:A retrospective review was conducted of patients who underwent injection laryngoplasty performed by a single laryngologist in a tertiary Australian laryngology centre, between February 2013 and December 2014. Patient demographics, anaesthetic modality and complications were recorded. Voice Handicap Index 10 and the Grade, Breathiness, Roughness, Asthenia, Strain scale were evaluated.Results:Thirty-four laryngoplasties were performed under general anaesthesia and 41 under local anaesthesia, with mean patient ages of 59.5 and 68.8 years, respectively. Voice Handicap Index 10 scores were significantly improved post-injection (p< 0.001), with no significant difference between general anaesthesia and local anaesthesia (p> 0.05). All aspects of the Grade, Breathiness, Roughness, Asthenia, Strain scale showed significant improvement post-injection, except asthenia. There were seven (9.3 per cent) minor complications (five in the general anaesthesia group, two in the local anaesthesia group), all managed conservatively.Conclusion:Injection laryngoplasties performed under general anaesthesia and local anaesthesia offer similar voice outcomes, with comparable complication rates. Hence, development of a management algorithm for injection laryngoplasties performed under local anaesthesia is recommended.
Inter-observer variability between radiologists reporting on cerebellopontine angle tumours on magnetic resonance imaging
Authors: Teh S R , Ranguis S , Fagan P 
Published: February 2017

AbstractBackground:Studies demonstrate the significance of intra- and inter-observer variability when measuring cerebellopontine angle tumours on magnetic resonance imaging, with measured differences as high as 2 mm.Objective:To determine intra- and inter-observer measurement variability of cerebellopontine angle tumours in a specialised institution.Methods:The magnetic resonance imaging maximal diameter of 12 randomly selected cerebellopontine angle tumours were independently measured by 4 neuroradiologists at a tertiary referral centre using a standard definition for maximal tumour diameter. Average deviation and intraclass correlation were subsequently calculated.Results:Inter-observer difference averaged 0.33 ± 0.04 mm (range, 0.0–0.8 mm). Intra-observer measurements were more consistent than inter-observer measurements, with differences averaging 0.17 mm (95 per cent confidence interval = 0.27–0.06, p = 0.002). Inter-observer reliability was 0.99 (95 per cent confidence interval = 0.97–0.99), suggesting high reliability between the readings.Conclusion:The use of a standard definition for maximal tumour volume provided high reliability amongst radiologists' readings. To avoid oversizing tumours, it is recommended that conservative monitoring be conducted by the same institution with thin slice magnetic resonance imaging scans.
The criminalisation of paying for sex in England and Wales: how gender and power are implicated in the making of policy
Authors: Mulvihill Natasha 
Published: February 2017

AbstractThis article considers how gender and power are implicated in how prostitution policy is translated from initial proposal to enactment in law. The analysis brings together Freeman’s proposal for “policy translation” (2009) and Connell’s work on “hegemonic masculinity” (1987 with Messerschmidt 2005) to examine Hansard and other United Kingdom Parliament documents relating to Clause 13/14 of the Policing and Crime Bill 2008–2009, a proposal to criminalise the purchase of sex in England and Wales. It is argued here that hegemonic masculinity is implicated in how “responsibility” and “exploitation” in relation to sex purchase are disputed and defined within the Parliamentary debates on Clause 13/14, and this in turn informed the version of criminalisation that emerged as authoritative. This article reflects finally on how far mapping the translation of policy can elucidate the operation of gender and power within the policy process.
Understanding rationales for collaboration in high-intensity policy conflicts
Authors: Weible Christopher M. , Heikkila Tanya , Pierce Jonathan 
Published: February 2017

AbstractWhy people collaborate to achieve their political objectives is one enduring question in public policy. Although studies have explored this question in low-intensity policy conflicts, a few have examined collaboration in high-intensity policy conflicts. This study asks two questions: What are the rationales motivating policy actors to collaborate with each other in high-intensity policy conflicts? What policy actor attributes are associated with these rationales? This study uses questionnaire data collected in 2013 and 2014 of policy actors from New York, Colorado and Texas who are actively involved with hydraulic fracturing policy debates. The results show that professional competence is the most important rationale for collaborating, whereas shared beliefs are moderately important, and financial resources are not important. Policy actor attributes that are associated with different rationales include organisational affiliation and extreme policy positions. This article concludes with a discussion on advancing theoretical explanations of collaboration in high-intensity policy conflicts.
Inequalities in the Pathway to College in China: When Do Students from Poor Areas Fall Behind?
Authors: Loyalka Prashant , Chu James , Wei Jianguo , Johnson Natalie , Reniker Joel 
Published: February 2017

AbstractInequalities in college access are a major concern for policymakers in both developed and developing countries. Policymakers in China have largely tried to address these inequalities by helping disadvantaged students successfully transition from high school to college. However, they have paid less attention to the possibility that inequalities in college access may also arise earlier in the pathway to college. The purpose of this paper is to understand where inequalities emerge along the pathway to college in China, focusing on three major milestones after junior high. By analysing administrative data on over 300,000 students from one region of China, we find that the largest inequalities in college access emerge at the first post-compulsory milestone along the pathway to college: when students transition from junior high to high school. In particular, only 60 per cent of students from poor counties take the high school entrance exam (compared to nearly 100 per cent of students from non-poor counties). Furthermore, students from poor counties are about one and a half times less likely to attend academic high school and elite academic high school than students from non-poor counties.
A large outbreak of gastrointestinal illness at an open-water swimming event in the River Thames, London
Authors: HALL V. , TAYE A. , WALSH B. , MAGUIRE H. , DAVE J. , WRIGHT A. , ANDERSON C. , CROOK P. 
Published: February 2017

SUMMARYOpen-water swimming is increasingly popular, often in water not considered safe for bathing. Limited evidence exists on the associated health risks. We investigated gastrointestinal illness in 1100 swimmers in a River Thames event in London, UK, to describe the outbreak and identify risk factors. We conducted a retrospective cohort study. Our case definition was swimmers with any: diarrhoea, vomiting, abdominal cramps lasting ⩾48 h, nausea lasting ⩾48 h, with onset within 9 days after the event. We used an online survey to collect information on symptoms, demographics, pre- and post-swim behaviours and open-water experience. We tested associations using robust Poisson regression. We followed up case microbiological results. Survey response was 61%, and attack rate 53% (338 cases). Median incubation period was 34 h and median symptom duration 4 days. Five cases had confirmed microbiological diagnoses (four Giardia, one Cryptosporidium). Wearing a wetsuit [adjusted relative risk (aRR) 6·96, 95% confidence interval (CI) 1·04–46·72] and swallowing water (aRR 1·42, 95% CI 1·03–1·97) were risk factors. Recent river-swimming (aRR 0·78, 95% CI 0·67–0·92) and age >40 years (aRR 0·83, 95% CI 0·70–0·98) were protective. Action to reduce risk of illness in future events is recommended, including clarification of oversight arrangements for future swims to ensure appropriate risk assessment and advice is provided.
Landscape-scale soil phosphorus variability in the McMurdo Dry Valleys
Authors: Heindel Ruth C. , Spickard Angela M. , Virginia Ross A. 
Published: February 2017

AbstractThe predicted increase in liquid water availability in the McMurdo Dry Valleys (MDV), Antarctica, may have profound consequences for nutrient cycling in soil and aquatic ecosystems. Our ability to predict future changes relies on our understanding of current nutrient cycling processes. Multiple hypotheses exist to explain the variability in soil phosphorus content and availability found throughout the MDV region. We analysed 146 surface soil samples from the MDV to determine the relative importance of parent material, landscape age, soil chemistry and texture, and topography on two biologically relevant phosphorus pools, HCl- and NaHCO3-extractable phosphorus. While HCl-extractable phosphorus is highly predicted by parent material, NaHCO3-extractable phosphorus is unrelated to parent material but is significantly correlated with soil conductivity, soil texture and topography. Neither measure of soil phosphorus was related to landscape age across a gradient of ~20 000 to 1 500 000 years. Glacial history has played an important role in the availability of soil phosphorus by shaping patterns of soil texture and parent material. With a predicted increase in water availability, the rate of mineral weathering may increase, releasing more HCl-extractable phosphorus into soil and aquatic ecosystems.
A rare case of a systemic-to-pulmonary veno-venous connection: a pause during development of pulmonary and systemic venous separation
Authors: Kwak Jae Gun , Kim Kyung-Hee , Lee Chang-Ha 
Published: February 2017

AbstractA 45-year-old man with dyspnoea and palpitations exhibited a unique systemic-to-pulmonary veno-venous connection on preoperative CT images. A window of 31.5-mm diameter was evident between the superior caval vein and the middle pulmonary vein, which was normally connected to the left atrium via a 30-mm-diameter orifice. The atrial septum was intact.
Are Parkinson’s Patients More Vulnerable to the Effects of Cardiovascular Risk: A Neuroimaging and Neuropsychological Study
Authors: Jones Jacob D. , Tanner Jared J. , Okun Michael , Price Catherine C. , Bowers Dawn 
Published: February 2017

AbstractObjectives:This study examined whether individuals with Parkinson’s disease (PD) are at increased vulnerability for vascular-related cognitive impairment relative to controls. The underlying assumption behind this hypothesis relates to brain reserve and that both PD and vascular risk factors impair similar fronto-executive cognitive systems.Methods:The sample included 67 PD patients and 61 older controls (totalN=128). Participants completed neuropsychological measures of executive functioning, processing speed, verbal delayed recall/memory, language, and auditory attention. Cardiovascular risk was assessed with the Framingham Cardiovascular Risk index. Participants underwent brain imaging (T1 and T2 FLAIR). Trained raters measured total and regional leukoaraiosis (periventricular, deep subcortical, and infracortical).Results:Hierarchical regressions revealed that more severe cardiovascular risk was related to worse executive functioning, processing speed, and delayed verbal recall in both Parkinson patients and controls. More severe cardiovascular risk was related to worse language functioning in the PD group, but not controls. In contrast, leukoaraiosis related to both cardiovascular risk and executive functioning for controls, but not the PD group.Conclusions:Overall, results revealed that PD and cardiovascular risk factors are independent risk factors for cognitive impairment. Generally, the influence of cardiovascular risk factors on cognition is similar in PD patients and controls. (JINS, 2017,23, 322–331)
Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor
Authors: Wu Tongde , Huang Julianne , Moore Patrick J. , Little Michael S. , Walton William G. , Fellner Robert C. , Alexis Neil E. , Peter Di Y. , Redinbo Matthew R. , Tilley Stephen L. , Tarran Robert 
Published: February 2017

AbstractAsthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family member A1, BPIFA1, is a secreted innate defence protein. Here we show that BPIFA1 levels are reduced in sputum samples from asthmatic patients and that BPIFA1 is secreted basolaterally from healthy, but not asthmatic human bronchial epithelial cultures (HBECs), where it suppresses ASM contractility by binding to and inhibiting the Ca2+ influx channel Orai1. We have localized this effect to a specific, C-terminal α-helical region of BPIFA1. Furthermore, tracheas from Bpifa1−/− mice are hypercontractile, and this phenotype is reversed by the addition of recombinant BPIFA1. Our data suggest that BPIFA1 deficiency in asthmatic airways promotes Orai1 hyperactivity, increased ASM contraction and airway hyperresponsiveness. Strategies that target Orai1 or the BPIFA1 deficiency in asthma may lead to novel therapies to treat this disease.
Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features
Authors: Seki Ryohei , Li Cai , Fang Qi , Hayashi Shinichi , Egawa Shiro , Hu Jiang , Xu Luohao , Pan Hailin , Kondo Mao , Sato Tomohiko , Matsubara Haruka , Kamiyama Namiko , Kitajima Keiichi , Saito Daisuke , Liu Yang , Gilbert M. Thomas P. , Zhou Qi , Xu Xing , Shiroishi Toshihiko , Irie Naoki , Tamura Koji , Zhang Guojie 
Published: February 2017

AbstractUnlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (>99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes.
Angle resolved photoemission spectroscopy reveals spin charge separation in metallic MoSe2 grain boundary
Authors: Ma Yujing , Diaz Horacio Coy , Avila José , Chen Chaoyu , Kalappattil Vijaysankar , Das Raja , Phan Manh-Huong , Čadež Tilen , Carmelo José M. P. , Asensio Maria C. , Batzill Matthias 
Published: February 2017

AbstractMaterial line defects are one-dimensional structures but the search and proof of electron behaviour consistent with the reduced dimension of such defects has been so far unsuccessful. Here we show using angle resolved photoemission spectroscopy that twin-grain boundaries in the layered semiconductor MoSe2 exhibit parabolic metallic bands. The one-dimensional nature is evident from a charge density wave transition, whose periodicity is given by kF/π, consistent with scanning tunnelling microscopy and angle resolved photoemission measurements. Most importantly, we provide evidence for spin- and charge-separation, the hallmark of one-dimensional quantum liquids. Our studies show that the spectral line splits into distinctive spinon and holon excitations whose dispersions exactly follow the energy-momentum dependence calculated by a Hubbard model with suitable finite-range interactions. Our results also imply that quantum wires and junctions can be isolated in line defects of other transition metal dichalcogenides, which may enable quantum transport measurements and devices.
Cell fate decisions emerge as phages cooperate or compete inside their host
Authors: Trinh Jimmy T. , Székely Tamás , Shao Qiuyan , Balázsi Gábor , Zeng Lanying 
Published: February 2017

AbstractThe system of the bacterium Escherichia coli and its virus, bacteriophage lambda, is paradigmatic for gene regulation in cell-fate development, yet insight about its mechanisms and complexities are limited due to insufficient resolution of study. Here we develop a 4-colour fluorescence reporter system at the single-virus level, combined with computational models to unravel both the interactions between phages and how individual phages determine cellular fates. We find that phages cooperate during lysogenization, compete among each other during lysis, and that confusion between the two pathways occasionally occurs. Additionally, we observe that phage DNAs have fluctuating cellular arrival times and vie for resources to replicate, enabling the interplay during different developmental paths, where each phage genome may make an individual decision. These varied strategies could separate the selection for replication-optimizing beneficial mutations during lysis from sequence diversification during lysogeny, allowing rapid adaptation of phage populations for various environments.
FAK signalling controls insulin sensitivity through regulation of adipocyte survival
Authors: Luk Cynthia T. , Shi Sally Yu , Cai Erica P. , Sivasubramaniyam Tharini , Krishnamurthy Mansa , Brunt Jara J. , Schroer Stephanie A. , Winer Daniel A. , Woo Minna 
Published: February 2017

AbstractFocal adhesion kinase (FAK) plays a central role in integrin signalling, which regulates growth and survival of tumours. Here we show that FAK protein levels are increased in adipose tissue of insulin-resistant obese mice and humans. Disruption of adipocyte FAK in mice or in 3T3 L1 cells decreases adipocyte survival. Adipocyte-specific FAK knockout mice display impaired adipose tissue expansion and insulin resistance on prolonged metabolic stress from a high-fat diet or when crossed on an obese db/db or ob/ob genetic background. Treatment of these mice with a PPARγ agonist does not restore adiposity or improve insulin sensitivity. In contrast, inhibition of apoptosis, either genetically or pharmacologically, attenuates adipocyte death, restores normal adiposity and improves insulin sensitivity. Together, these results demonstrate that FAK is required for adipocyte survival and maintenance of insulin sensitivity, particularly in the context of adipose tissue expansion as a result of caloric excess.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo
Authors: Huang Tao , Xiao Yubo , Yi Lin , Li Ling , Wang Meimei , Tian Cheng , Ma Hang , He Kai , Wang Yue , Han Bing , Ye Xiaoli , Li Xuegang 
Published: February 2017

AbstractColorectal cancer is one of the most common causes of cancer-related death in humans. Coptisine (COP) is a natural alkaloid from Coptidis Rhizoma with unclear antitumor mechanism. Human colon cancer cells (HCT-116) and xenograft mice were used to systematically explore the anti-tumor activity of COP in this study. The results indicated that COP exhibited remarkably cytotoxic activities against the HCT-116 cells by inducing G1-phase cell cycle arrest and increasing apoptosis, and preferentially inhibited the survival pathway and induced the activation of caspase proteases family of HCT-116 cells. Experimental results on male BALB/c nude mice confirmed that orally administration of COP at high-dose (150 mg/kg) could suppress tumor growth, and may reduce cancer metastasis risk by inhibiting the RAS-ERK pathway in vivo. Taken together, the results suggested that COP may be potential as a novel anti-tumor candidate in the HCT-116 cells-related colon cancer, further studies are still needed to suggest COP for the further use.
Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization
Authors: Han Kyu-Yeon , Tran Jennifer A. , Chang Jin-Hong , Azar Dimitri T. , Zieske James D. 
Published: February 2017

AbstractSpecific factors from the corneal epithelium underlying the stimulation of stromal fibrosis and myofibroblast formation in corneal wound healing have not been fully elucidated. Given that exosomes are known to transfer bioactive molecules among cells and play crucial roles in wound healing, angiogenesis, and cancer, we hypothesized that corneal epithelial cell-derived exosomes may gain access to the underlying stromal fibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events essential for corneal wound healing. In the present study, exosome-like vesicles were observed between corneal epithelial cells and the stroma during wound healing after corneal epithelial debridement. These vesicles were also found in the stroma following anterior stromal keratectomy, in which surgical removal of the epithelium, basement membrane, and anterior stroma was performed. Exosomes secreted by mouse corneal epithelial cells were found to fuse to keratocytes in vitro and to induce myofibroblast transformation. In addition, epithelial cell-derived exosomes induced endothelial cell proliferation and ex vivo aortic ring sprouting. Our results indicate that epithelial cell-derived exosomes mediate communication between corneal epithelial cells and corneal keratocytes as well as vascular endothelial cells. These findings demonstrate that epithelial-derived exosomes may be involved in corneal wound healing and neovascularization, and thus, may serve as targets for potential therapeutic interventions.
Seawater acidification induced immune function changes of haemocytes in Mytilus edulis: a comparative study of CO2 and HCl enrichment
Authors: Sun Tianli , Tang Xuexi , Jiang Yongshun , Wang You 
Published: February 2017

AbstractThe present study was performed to evaluate the effects of CO2− or HCl-induced seawater acidification (pH 7.7 or 7.1; control: pH 8.1) on haemocytes of Mytilus edulis, and the changes in the structure and immune function were investigated during a 21-day experiment. The results demonstrated that seawater acidification had little effect on the cellular mortality and granulocyte proportion but damaged the granulocyte ultrastructure. Phagocytosis of haemocytes was also significantly inhibited in a clearly concentration-dependent manner, demonstrating that the immune function was affected. Moreover, ROS production was significantly induced in both CO2 and HCl treatments, and four antioxidant components, GSH, GST, GR and GPx, had active responses to the acidification stress. Comparatively, CO2 had more severe destructive effects on haemocytes than HCl at the same pH level, indicating that CO2 stressed cells in other ways beyond the increasing H+ concentration. One possible explanation was that seawater acidification induced ROS overproduction, which damaged the ultrastructure of haemocytes and decreased phagocytosis.