bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative exercise training prevents functional decline after lung resection surgery: a randomized, single-blind controlled trial
Authors: Sebio García Raquel , Yáñez-Brage Maria Isabel , Giménez Moolhuyzen Esther , Salorio Riobo Marta , Lista Paz Ana , Borro Mate Jose María 
Published: January 2017

Objectives: To investigate the effects of a preoperative pulmonary rehabilitation programme in patients with lung cancer undergoing video-assisted thoracic surgery. Design: Randomized, single-blind controlled trial. Setting: Teaching hospital. Subjects: Patients with suspected or confirmed lung cancer undergoing video-assisted thoracic surgery. Intervention: Participants were randomized to either a prehabilitation group or a control group. Participants in the prehabilitation group underwent a combination of moderate endurance and resistance training plus breathing exercises three to five times per week. Main measures: The primary outcome of the study was exercise capacity. Secondary outcomes were muscle strength (Senior Fitness Test), health-related quality of life (Short-Form 36) and the postoperative outcomes. Patients were evaluated at baseline (before randomization), presurgery (only the prehabilitation group), after surgery and three months post-operatively. Results: A total of 40 patients were randomized and 22 finished the study (10 in the prehabilitation group and 12 in the control group). Three patients were lost to follow-up at three months. After the training, there was a statistically significant improvement in exercise tolerance (+397 seconds, p = 0.0001), the physical summary component of the SF-36 (+4.4 points, p = 0.008) and muscle strength ( p < 0.01). There were no significant differences between groups after surgery. However, three months postoperatively, significant differences were found in the mean change of exercise capacity ( p = 0.005), physical summary component ( p = 0.001) and upper and lower body strength ( p = 0.045 and p = 0.002). Conclusions: A pulmonary rehabilitation programme before video-assisted thoracic surgery seems to improve patients’ preoperative condition and may prevent functional decline after surgery. Clinical Registration Number: NCT01963923 (Registration date 10/10/2013)
Functional deficits induced by cortical microinfarcts
Authors: Summers Philipp M , Hartmann David A , Hui Edward S , Nie Xingju , Deardorff Rachael L , McKinnon Emilie T , Helpern Joseph A , Jensen Jens H , Shih Andy Y 
Published: January 2017

Clinical studies have revealed a strong link between increased burden of cerebral microinfarcts and risk for cognitive impairment. Since the sum of tissue damage incurred by microinfarcts is a miniscule percentage of total brain volume, we hypothesized that microinfarcts disrupt brain function beyond the injury site visible to histological or radiological examination. We tested this idea using a mouse model of microinfarcts, where single penetrating vessels that supply mouse cortex were occluded by targeted photothrombosis. We found that in vivo structural and diffusion MRI reliably reported the acute microinfarct core, based on spatial co-registrations with post-mortem stains of neuronal viability. Consistent with our hypothesis, c-Fos assays for neuronal activity and in vivo imaging of single vessel hemodynamics both reported functional deficits in viable peri-lesional tissues beyond the microinfarct core. We estimated that the volume of tissue with functional deficit in cortex was at least 12-fold greater than the volume of the microinfarct core. Impaired hemodynamic responses in peri-lesional tissues persisted at least 14 days, and were attributed to lasting deficits in neuronal circuitry or neurovascular coupling. These data show how individually miniscule microinfarcts could contribute to broader brain dysfunction during vascular cognitive impairment and dementia.
Development and validation of a predictor of insufficient enhancement during the hepatobiliary phase of Gd-EOB-DTPA-enhanced magnetic resonance imaging
Authors: Cui Enming , Long Wansheng , Luo Liangping , Hu Maoqing , Huang Liebin , Chen Xiangmeng 
Published: January 2017

Background Insufficient enhancement of liver parenchyma negatively affects diagnostic accuracy of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI). Currently, there is no reliable method for predicting insufficient enhancement during the hepatobiliary phase (HBP) in Gd-EOB-DTPA-enhanced MRI. Purpose To develop a predictor for insufficient enhancement of liver parenchyma during HBP in Gd-EOB-DTPA-enhanced MRI. Material and Methods In order to formulate a HBP enhancement test (HBP-ET), clinical factors associated with relative enhancement ratio (RER) of liver parenchyma were retrospectively determined from the datasets of 156 patients (Development group) who underwent Gd-EOB-DTPA-enhanced MRI between November 2012 and May 2015. The independent clinical factors were identified by Pearson’s correlation and multiple stepwise regression analysis; the performance of HBP-ET was compared to Child-Pugh score (CPS), Model for End-stage Liver Disease score (MELD), and total bilirubin (TBIL) using receiver operating characteristic (ROC) curve analysis. The datasets of 52 patients (Validation group), which were examined between June 2015 and Oct 2015, were applied to validate the HBP-ET. Results Six biochemical parameters independently influenced RER and were used to develop HBP-ET. The mean HBP-ET score of patients with insufficient enhancement was significantly higher than that of patients with sufficient enhancement ( P < 0.001) in both the Development and Validation groups. HBP-ET (area under the curve [AUC] = 0.895) had better performance in predicting insufficient enhancement than CPS (AUC = 0.707), MELD (AUC = 0.798), and TBIL (AUC = 0.729). Conclusion The HBP-ET is more accurate than routine indicators in predicting insufficient enhancement during HBP, which is valuable to aid clinical decisions.
A Comparison of a Short Course of Single Daily Dosage Therapy of Tinidazole with Metronidazole in Intestinal Amoebiasis
Authors: Misra N P , Gupta R C 
Published: January 2017

Sixty patients with symptomatic intestinal amoebiasis were treated for 3 days with a single dose of 2 g of either tinidazole or metronidazole respectively by random order. Tinidazole cured 90% of patients (27/30) and metronidazole cured 53.3% of patients (16/30). The difference was significant (p < 0.01). Mild side-effects were reported by 26.7% of patients (8/30) in the tinidazole group as compared to mild to moderate side effects reported by 53.3% of patients (16/30) in the metronidazole group. The difference was statistically significant (p<0.05). As the average patient has only a limited understanding and toleration of extended treatment courses, the advantages of a short course employing a single daily dose are obvious. With such a regimen, tinidazole was found to be superior to metronidazole in intestinal amoebiasis.
Some Aspects of the Psychopharmacological Activity of Maprotiline (Ludiomil®): Effects of Single and Repeated Treatments
Authors: Delini-Stula A , Radeke E , Vassout A 
Published: January 2017

Three different aspects of the psychopharmacological activity of the antidepressant maprotiline were investigated: its influence on serotoninergic functions the effects produced by chronic treatment its central nervous depressant and anxiolytic properties. Study of the effects of maprotiline on 5-HTP-induced head-twitch in mice pre-treated with pargyline or on hyperpyrexia in rats provided no evidence that the drug interferes with serotonin-mediated functions in the central nervous system even after quite high doses. These findings corroborate the results of extensive neurobiochemical investigations, which failed to demonstrate any influence of maprotiline on the metabolism of serotonin. Chronic studies showed that classical effects of maprotiline such as antagonism against reserpine-induced ptosis or tetrabenazine-induced catalepsy do not change in their intensity after daily administration of the drugs in a dose of 30 mg/kg p.o.for 11 days. A new component of the action of the compound, not detectable after one single dose, seems to appear, however, after repeated treatment (8 days). This effect is manifested in the restoration of conditioned avoidance behaviour after its suppression by pre-treatment with reserpine. The same effect is produced by imipramine. It is suggested that this restorative effect may be due to an additional activation of the dopaminergic nervous system and may have a bearing on the appearance of clinical antidepressant effects. Maprotiline was found to potentiate central nervous depressant effects of drugs like chlorpromazine, phenobarbitone and propranolol. This affords further confirmation that, in addition to its antidepressant qualities, it possesses sedative actions. An anxiolytic component was also demonstrated in rats in which maprotiline suppressed the conditioned, fear-induced rise in body-temperature.
Preventive Treatment of Migraine Headache with a New Isoergolenyl Derivative
Authors: Herrmann W M , Krištof M , Hernandez M Sastre y 
Published: January 2017

In the present double-blind clinical trial an isoergolenyl derivative with periphal antiserotonin, central dopaminergic activity and a-increasing effect on the human EEG, lisuride hydrogen maleate, was tested against placebo in a six-month trial involving 240 patients. Lisuride in long-term administration significantly reduces the frequency of migraine attacks in comparison to placebo. Its advantages are good tolerance and minimal side-effects. It is therefore concluded that lisuride is a suitable and effective drug for the prevention of migraine.
Effect of Vaporub on the Restlessness of Children with Acute Bronchitis
Authors: Berger H , Madreiter H , Jarosch E 
Published: January 2017

In this study pneumographs of children with acute bronchitis treated with Vicks Vaporub®* or Petrolatum were used. Movement artifacts were used as a measure of the so-called “restlessness” of the children. The experimental schedule consisted of a 10-minute phase of recording before a 3-minute treatment with Vaporub® or Petrolatum, followed by a 70-minute observation period, during which time pneumograms were also recorded. Thirty-four Vaporub®-treated children showed an increase in periods without movement artifacts of up to 213.8%, the Petrolatum controls, twenty-six children, up to 62.4% as compared to the corresponding pre-treatment values. It is concluded that Vaporub® is effective in decreasing restlessness in children suffering from acute bronchitis. This effect is quite marked and cannot be due solely to psychological effects of the rub therapy, or to effects of petrolatum without aromatics.
Effects of Pimobendan (UDCG 115) on Renal Function in Healthy Volunteers
Authors: Martin P , Tindall H , Rice P , Jones P , Tregunno G , Davies J A , Prentice C R M 
Published: January 2017

A phase I, double-blind, single-dose, randomized, two-period crossover study was conducted to investigate the effects of pimobendan on renal function to assess whether renal events were a contra-indication to its administration. Results in eight healthy volunteers indicated no significant adverse events on renal plasma flow, glomerular filtration rate, or laboratory safety screens; side-effects were also found to be minimal. Further studies are indicated to assess whether, in the proposed treatment group, i.e. patients with heart failure (in whom compromised renal function is common), pimobendan similarly elicits no serious adverse renal effects. Unter Verabreichung einer Einzeldosis wurde eine randomisierte, über zwei Zeitspannen stattfindende gekreuzte Doppelblindstudie der Phase I durchgeführt, um die Effekte von Pimobendan auf die Nierenfunktion zu untersuchen. Diese Untersuchung diente der Beurteilung, ob eine gestörte Nierenfunktion als Gegenanzeige für die Verabreichung dieses Präparates zu bewerten ist. Die an acht gesunden Freiwilligen ermittelten Ergebnisse ließen keine signifikanten, unerwünschten Ereignisse auf den renalen Plasmafluß, auf die glomeruläre Filtrationsrate oder auf die Ergebnisse der im Labor durchgeführten Sicherheits-Screening-Tests erkennen. Darüber hinaus wurde auch festgestellt, daß die Nebenwirkungen geringgradig waren. Es sind weitere Studien angezeigt, um zu beurteilen, ob in der vorgeschlagenen Behandlungsgruppe, das heißt bei Patienten mit Herzversagen, bei denen eine gestörte Nierenfunktion häufig vorkommt, Pimobendan auf ganz ähnliche Weise keine schweren unerwünschten Effekte auf die Nieren hervorruft.
United European Gastroenterology evidence‐based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)
Authors: Löhr J Matthias , Dominguez‐Munoz Enrique , Rosendahl Jonas , Besselink Marc , Mayerle Julia , Lerch Markus M , Haas Stephan , Akisik Fatih , Kartalis Nikolaos , Iglesias‐Garcia Julio , Keller Jutta , Boermeester Marja , Werner Jens , Dumonceau Jean‐Marc , Fockens Paul , Drewes Asbjorn , Ceyhan Gürlap , Lindkvist Björn , Drenth Joost , Ewald Nils , Hardt Philip , de Madaria Enrique , Witt Heiko , Schneider Alexander , Manfredi Riccardo , Brøndum Frøkjer J , Rudolf Sasa , Bollen Thomas , Bruno Marco ,   HaPanEU/UEG Working Group
Published: January 2017

BackgroundThere have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence‐based approach.MethodsTwelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one‐day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers.ResultsThe 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations.ConclusionsThe 2016 HaPanEU/United European Gastroenterology guidelines provide evidence‐based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.
SLP-educator classroom collaboration: A review to inform reason-based practice
Authors: Archibald Lisa MD 
Published: January 2017

Background and aims Increasingly, speech language pathologists are engaging in collaborative classroom services with teachers and other educators to support children with developmental language disorder and other communication impairments. Recent systematic reviews have provided a summary of only a small fraction of the available evidence and recommended the use of reason-based practice in the absence of a sufficient empirically driven evidence base. The purpose of this paper was to provide a broad (but critical) review of the existing evidence. Main contribution Papers were gathered through review of reference lists in the recent systematic reviews and other published works, as well as general internet searches. A total of 49 papers were identified either reporting empirical evidence pertaining to SLP-educator collaborative classroom activities, empirical evidence pertaining to consultative services, classroom instruction, or small group intervention in the classroom, or providing information, discussion, surveys, or reviews related to the topic. Evidence pertaining to vocabulary, oral language, phonological awareness, curriculum-based language, and written language were summarized together with qualifications based on elements of the research design. Conclusion and implications Although much of the evidence must be interpreted with considerable caution, the present review is informative for clinicians looking to adopt a reason-based approach to practice.
Tolerogenic interactions between CD8+ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts
Authors: Hongo David , Tang Xiaobin , Zhang Xiangyue , Engleman Edgar G. , Strober Samuel 
Published: January 2017

Key PointsTolerance after bone marrow transplantation requires CD8+ DCs and NKT-cell interaction. CD8+ DCs and NKT cells become tolerogenic after conditioning with total lymphoid irradiation.
Lymphangiogenesis is a feature of acute GVHD, and VEGFR-3 inhibition protects against experimental GVHD
Authors: Mertlitz Sarah , Shi Yu , Kalupa Martina , Grötzinger Carsten , Mengwasser Jörg , Riesner Katarina , Cordes Steffen , Elezkurtaj Sefer , Penack Olaf 
Published: January 2017

Key Points
aGVHD after hematopoietic stem cell transplantation is associated with lymphangiogenesis in the intestinal tract and lymph nodes. Inhibition of lymphangiogenesis by antibodies against VEGFR-3 ameliorated aGVHD.
Tissue is the issue and tissue competition. Re‐biopsy for mutation T790: where and why?
Authors: Zarogoulidis Paul , Gaga Mina , Huang Haidong , Darwiche Kaid , Rapti Aggeliki , Hohenforst‐Schmidt Wolfgang 
Published: January 2017

AbstractLung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epidermal growth factor receptor (EGFR) positive patients in adenocarcinoma or mixed adenosquamus lung cancer patients. However; while novel drugs are released in the market, at the same time novel mutations are observed after tyrosine kinase inhibitor administration. Recently the novel mutation T790 was observed and is highly prevalent in patients already treated with a TKI. A new drug targeting this mutation is already on the market, however; the most important factor for successful treatment in these patients, is adequate tissue re‐sampling so that novel mutations can be detected.
JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin
Authors: Yoshitomi Yasuo , Ikeda Takayuki , Saito Hidehito , Yoshitake Yoshino , Ishigaki Yasuhito , Hatta Toshihisa , Kato Nobuo , Yonekura Hideto 
Published: January 2017

ABSTRACT
Blood vessels and nerve fibers are often closely arranged in parallel throughout the body. Therefore, neurovascular interactions have been suggested to be important for the development of vascular networks. However, the molecular mechanisms and genes regulating this process remain unclear. In the present study, we investigated the genes that are activated in endothelial cells (ECs) following interactions with neurons during vascular development. Microarray analyses of human primary microvascular ECs co-cultured with mouse primary dorsal root ganglion cells showed that JunB is strongly upregulated in ECs by neurovascular interactions. Furthermore, the forced expression of JunB in ECs stimulated a tip-like cell formation and angiogenesis in vitro and induced vascular endothelial growth factor A (VEGFA) and the pro-angiogenic integrin subunit ITGB3 expression. Moreover, in vivo knockdown of JunB in ECs from developing mouse limb skin considerably decreased the parallel alignments of blood vessels and nerve fibers. Taken together, the present data demonstrates for the first time that JunB plays an important role in the formation of embryonic vascular networks. These results contribute to the molecular understanding of neurovascular interactions during embryonic vascular development.
A New Empirical Relation between the Enthalpy of Vaporization and (Tc − Tm) for the Liquids of Similar Chemical Groups (Tc: Critical Temperature, Tm: Melting Temperature)
Authors: Kanno Hitoshi 
Published: January 2017

Abstract
A new empirical linear relation between the enthalpy of vaporization and (Tc − Tm) (Tc: critical temperature, Tm: melting temperature) is presented for liquids of similar chemical groups. Combination of the above finding with Trouton’s rule leads to another linear relation between Tb (boiling temperature) and (Tc − Tm). As an extension, a different expression for the Guldberg rule is also derived. These findings can contribute to the understanding of general behavior of liquids and the development of theories of liquids.
Technology Mergers and Acquisitions in the Presence of an Installed Base: A Strategic Analysis
Authors: Wang Qiu-Hong , Hui Kai-Lung 
Published: January 2017

We study the strategic benefits of mergers and acquisitions (M&As) when competing information technology vendors sell different generations of the same product with different quality. We assume the new product arrives unexpectedly when an installed base of the old product exists. We show that the combination of consumers’ purchase history and heterogeneity leads to new demand complexity that gives rise to innovative product strategies. We find that shelving the old product is an important motivation for M&A. The acquirer may exercise static or intertemporal price discrimination depending on whether it can exercise upgrade pricing. M&A may speed up or slow down new product consumption, and it can lead to delayed new product introduction in some markets. However, it always increases the acquirer’s profit and can sometimes help maximize social welfare. We discuss relevant managerial and policy implications.The online appendix is available at https://doi.org/10.1287/isre.2016.0659 .
Nondegeneracy of positive solutions to nonlinear Hardy–Sobolev equations
Authors: Robert Frédéric 
Published: January 2017

Abstract
In this note, we prove that the kernel of the linearized equation around a positive energy solution in

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