bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mutation in the progesterone receptor predisposes to HEV infection in HIV‐positive patients
Authors: Debes Jose D. , Pas Suzan D. , Groothuismink Zwier M. A. , van der Ende Marchina E. , de Man Robert A. , Boonstra Andre 
Published: December 2017

AbstractBackground and AimsInfection with Hepatitis E virus (HEV) can cause chronic liver disease in immunocompromised hosts. In transplant recipients, the use of certain immunosuppressants and food habits has been proposed as risk factors for HEV. In individuals infected with the human immunodeficiency virus (HIV), risk factors for HEV infection are less clear. We aimed to study the association between a mutation in the progesterone receptor (PR) named PROGINS and HEV‐infected in HIV‐positive individuals.MethodsWe evaluated the presence of the SNP PROGINS via KASP in serum samples of 64 HIV‐positive individuals and 187 healthy controls. We performed ELISA tests to address the serum levels of IL‐10 and IL‐12, as well as T‐cell stimulation assays in peripheral blood to address immune response in individuals with PROGINS.ResultsWe found a significant association between the presence of PROGINS mutation and HEV seroprevalence in individuals infected with HIV (30% in HIV+/HEV+ versus 2% in HIV+/HEV, respectively, P = .009). Moreover, we found that HIV+/HEV+ individuals expressing the PROGINS mutation had lower serum levels of IL‐10 and higher levels of IL‐12. The presence of the mutation led to a reduced response upon stimulation of CD4+ and CD8+ T cells compared to those without the mutation, suggesting an immune modulation associated with PROGINS.ConclusionsOur study identified a mutation in the PR that provides significant insights into mechanisms of HEV infection in immunosuppressed individuals.
From Common Prayer to Common Ancestor: The Quest for Anglican Liturgical Identity and the Legacy of the Reformation
Authors: Nichols Bridget 
Published: December 2017

AbstractAnglicanism's relationship with its Reformation heritage represents a tension. It looks to the Reformation as the movement from which an English Church, independent of papal authority, was inaugurated. At the same time, it refuses to be labelled as a “church of the Reformation”, pointing to its continuity with a much longer history of Christian practice in Britain. The growth of the Anglican Communion and current controversies over church order, the interpretation of scripture and the exercise of authority make Anglican identity difficult to define. Identity would once have been sought in liturgy, but the view that liturgy completely enshrines Anglican doctrine has been convincingly put to rest by scholarship since the 1970s. This paper argues that the liturgical legacy of the Reformation (especially use of the vernacular, concern for the orderly reading and interpretation of scripture, and attention given to the sacraments of baptism and the Eucharist) offers categories that can help to form possible approaches to the current crisis of Anglican identity.
The Effects of Immigration on Household Services, Labour Supply and Fertility
Authors: Romiti Agnese 
Published: December 2017

AbstractFertility and female labour force participation are no longer negatively correlated in developed countries. At the same time, increased immigration affects supply and prices of household services, which are relevant to fertility and employment decisions. This paper analyses the effect of immigration on labour supply and fertility of native women in the UK. Adopting an instrumental variable approach, I find that immigration increases female labour supply without affecting fertility. My results show that immigration increases the size of the childcare sector, and reduces its prices, suggesting that immigrants may ease the trade‐off between working and child rearing among native women.
A Markov Switching Factor‐Augmented VAR Model for Analyzing US Business Cycles and Monetary Policy
Authors: Huber Florian , Fischer Manfred M. 
Published: December 2017

AbstractThis paper develops a Markov switching factor‐augmented vector autoregression to investigate the transmission mechanisms of monetary policy for distinct stages of the US business cycle. We assume that autoregressive parameters and covariance matrices of the error terms are regime dependent, driven by an unobserved Markov indicator. Endogenously determined transition probabilities are governed by an underlying probit model that features a large set of possible predictors. The empirical findings provide evidence for differences in the transmission of monetary policy shocks that mainly stem from heterogeneity in the responses of financial market quantities.
Axially Decorated SiIV‐phthalocyanines Bearing Mannose‐ or Ammonium‐conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation,
Authors: Grüner Malte C. , Niemann Silke , Faust Andreas , Strassert Cristian A. 
Published: December 2017

AbstractHerein, we present a comparative study about the photoinactivation of Staphylococcus aureus (Gram‐positive model) and Escherichia coli (Gram‐negative model) employing a neutral and a dicationic axially functionalized SiIV‐phthalocyanine. Depending on the charge of the siloxane moiety (neutral monosaccharide or cationic ammonium salt), different interactions with the bacteria were observed, and a differential photoinactivation was facilitated. The intensity of the fluorescence labeling correlated with the photoinactivation of the two types of bacteria: While the neutral species only significantly affected the Gram‐positive cells, we observed that the positively charged photosensitizer interacted both with the Gram‐positive and with the Gram‐negative models. The dicationic photosensitizer labeled both models with a characteristic deep‐red fluorescence and photoinactivated both classes of prokaryotes. In general, our study clearly demonstrates that axially ammoniumsiloxane‐functionalized Si(IV) phthalocyaninates constitute excellent photosensitizers due to their weak aggregation in aqueous environments. In particular, we also show that charge‐based targeting with axial ammonium groups leads toward broad‐spectrum SiIV‐phthalocyanines for photodynamic inactivation of bacteria.
Effectiveness and cost-effectiveness of a guided internet- and mobile-based depression intervention for individuals with chronic back pain: protocol of a multi-centre randomised controlled trial
Authors: Lin Jiaxi , Sander Lasse , Paganini Sarah , Schlicker Sandra , Ebert David , Berking Matthias , Bengel Jürgen , Nobis Stephanie , Lehr Dirk , Mittag Oskar , Riper Heleen , Baumeister Harald 
Published: December 2017

IntroductionDepression often co-occurs with chronic back pain (CBP). Internet and mobile-based interventions (IMIs) might be a promising approach for effectively treating depression in this patient group. In the present study, we will evaluate the effectiveness and cost-effectiveness of a guided depression IMI for individuals with CBP (eSano BackCare-D) integrated into orthopaedic healthcare.Methods and analysisIn this multicentre randomised controlled trial of parallel design, the groups eSano BackCare-D versus treatment as usual will be compared. 210 participants with CBP and diagnosed depression will be recruited subsequent to orthopaedic rehabilitation care. Assessments will be conducted prior to randomisation and 9 weeks (post-treatment) and 6 months after randomisation. The primary outcome is depression severity (Hamilton Rating Scale for Depression-17). Secondary outcomes are depression remission and response, health-related quality of life, pain intensity, pain-related disability, self-efficacy and work capacity. Demographic and medical variables as well as internet affinity, intervention adherence, intervention satisfaction and negative effects will also be assessed. Data will be analysed on an intention-to-treat basis with additional per-protocol analyses. Moreover, a cost-effectiveness and cost-utility analysis will be conducted from a societal perspective after 6 months.Ethics and disseminationAll procedures are approved by the ethics committee of the Albert-Ludwigs-University of Freiburg and the data security committee of the German Pension Insurance (Deutsche Rentenversicherung). The results will be published in peer-reviewed journals and presented on international conferences.Trial registration numberDRKS00009272; Pre-results.
Applicability of evidence from previous systematic reviews on immunotherapy in current practice of childhood asthma treatment: a GRADE (Grading of Recommendations Assessment, Development and Evaluation) systematic review
Authors: van de Griendt Erik-Jonas , Tuut Mariska K , de Groot Hans , Brand Paul L P 
Published: December 2017

ObjectiveBecause most children with asthma now use inhaled corticosteroids (ICS), the added benefit of immunotherapy in asthmatic children needs to be examined. We re-assessed the effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) in childhood asthma treatment focusing on studies with patient-relevant outcome measures and children using ICS.MethodsWe used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to systematically search and appraise the evidence using predefined critical patient-relevant outcomes (asthma symptoms, asthma control and exacerbations). We searched to retrieve systematic reviews and randomised controlled trials on immunotherapy for asthma in children (1960–2017). We assessed the quality of the body of evidence with GRADE criteria.ResultsThe quality of the evidence for SCIT was very low due to a large risk of bias and indirectness (dated studies in children not using ICS). No effect of SCIT was found for asthma symptoms; no studies reported on asthma control. For asthma exacerbations, studies favoured SCIT. We have little confidence in this effect estimate, due to the very low quality of evidence. For SLIT, quality of the evidence was very low due to a large risk of bias, indirectness and imprecision. The outcome ‘asthma symptoms’ could not be calculated due to lack of standardisation and large clinical heterogeneity. Other predefined outcomes were not reported.ConclusionThe beneficial effects of immunotherapy in childhood asthma found in earlier reviews are no longer considered applicable, because of indirectness (studies performed in children not being treated according to current asthma guidelines with ICS). There was absence of evidence to properly determine the effectiveness or lack thereof of immunotherapy in asthma treatment in children with ICS.
Why don’t key populations access HIV testing and counselling centres in Nepal? Findings based on national surveillance survey
Authors: Shrestha Rachana , Philip Sairu , Shewade Hemant Deepak , Rawal Bir , Deuba Keshab 
Published: December 2017

ObjectivesTo assess the demographic, behavioural, psychosocial and structural factors associated with non-utilisation of HIV testing and counselling (HTC) services by female sex workers (FSWs) and men who have sex with men/transgender (MSM/TG).MethodsThis study involved a cross-sectional design. We used the national surveillance survey data of 2012, which included 610 FSWs and 400 MSM/TG recruited randomly from 22 and three districts of Nepal, respectively. Adjusted prevalence ratio (aPR) and 95% confidence interval (CI) using modified Poisson regression was used to assess and infer the association between outcome (non-utilisation of HTC in last year) and independent variables.ResultsNon-utilisation of HTC in the last year was 54% for FSWs and 55% for MSM/TG. The significant factors for non-utilisation of HTC among FSWs were depression (aPR=1.4 (95% CI 1.1 to 1.6)), injectable drug abuse (ever) (aPR=1.4 (95% CI 1.1 to 1.8)), participation (ever) in HIV awareness programmes (aPR=1.2 (95% CI 1.0 to 1.4)), experience of forced sex in previous year (aPR=1.1 (95% CI 1.0 to 1.3)) and absence of dependents in the family (aPR=1.1 (95% CI 1.0 to 1.3)). Non-utilisation of HTC among MSM/TG had significant association with age 16–19 years (aPR=1.4 (95% CI 1.1 to 1.7)), non-condom use (aPR=1.2 (95% CI 1.0 to 1.4)), participation (ever) in HIV awareness programmes (aPR=1.6 (95% CI 1.3 to 2.0)), physical assault in previous year (aPR=1.8 (95% CI 1.0 to 3.1)), experience of forced sex in previous year (aPR=0.5 (95% CI 0.3 to 0.9)).ConclusionAlthough limited by cross-sectional design, we found many programmatically relevant findings. Creative strategies should be envisaged for effective behavioural change communication to improve access to HIV testing. Psychosocial and structural interventions should be integrated with HIV prevention programmes to support key populations in accessing HIV testing.
Performance of syndromic management for the detection and treatment of genitalChlamydia trachomatis,Neisseria gonorrhoeaeandTrichomonas vaginalisamong women attending antenatal, well woman and sexual health clinics in Papua New Guinea: a cross-sectional study
Authors: Vallely Lisa M , Toliman Pamela , Ryan Claire , Rai Glennis , Wapling Johanna , Gabuzzi Josephine , Allen Joyce , Opa Christine , Munnull Gloria , Kaima Petronia , Kombuk Benny , Kumbia Antonia , Kombati Zure , Law Greg , Kelly-Hanku Angela , Wand Handan , Siba Peter M , Mola Glen D L , Kaldor John M , Vallely Andrew J 
Published: December 2017

ObjectivePapua New Guinea (PNG) has among the highest estimated prevalences of genitalChlamydia trachomatis(CT),Neisseria gonorrhoeae(NG) andTrichomonas vaginalis(TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG.DesignWomen attending antenatal (ANC), well woman (WWC) and sexual health (SHC) clinics in four provinces were invited to participate, completed a face-to-face interview and clinical examination, and provided genital specimens for laboratory testing. We estimated the performance characteristics of syndromic diagnoses against combined laboratory diagnoses.Results1764 women were enrolled (ANC=765; WWC=614; SHC=385). The prevalences of CT, NG and TV were highest among women attending ANC and SHC. Among antenatal women, syndromic diagnosis of sexually transmitted infection had low sensitivity (9%–21%) and positive predictive value (PPV) (7%–37%), but high specificity (76%–89%) and moderate negative predictive value (NPV) (55%–86%) for the combined endpoint of laboratory-confirmed CT, NG or TV. Among women attending WWC and SHC, ‘vaginal discharge syndrome’ had moderate to high sensitivity (72%–78%) and NPV (62%–94%), but low specificity (26%–33%) and PPV (8%–38%). ‘Lower abdominal pain syndrome’ had low sensitivity (26%–41%) and PPV (8%–23%) but moderate specificity (66%–68%) and high NPV (74%–93%) among women attending WWC, and moderate-high sensitivity (67%–79%) and NPV (62%–86%) but low specificity (26%–28%) and PPV (14%–33%) among SHC attendees.ConclusionThe performance of syndromic management for the detection and treatment of genital chlamydia, gonorrhoea and trichomonas was poor among women in different clinical settings in PNG. New diagnostic strategies are needed to control these infections and to prevent their adverse health outcomes in PNG and other high-burden countries.
Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis
Authors: Grigor Emma J M , Fergusson Dean A , Haggar Fatima , Kekre Natasha , Atkins Harold , Shorr Risa , Holt Robert A , Hutton Brian , Ramsay Tim , Seftel Matthew , Jonker Derek , Daugaard Mads , Thavorn Kednapa , Presseau Justin , Lalu Manoj M 
Published: December 2017

IntroductionPatients with relapsed or refractory malignancies have a poor prognosis. Immunotherapy with chimeric antigen receptor T (CAR-T) cells redirects a patient’s immune cells against the tumour antigen. CAR-T cell therapy has demonstrated promise in treating patients with several haematological malignancies, including acute B-cell lymphoblastic leukaemia and B-cell lymphomas. CAR-T cell therapy for patients with other solid tumours is also being tested. Safety is an important consideration in CAR-T cell therapy given the potential for serious adverse events, including death. Previous reviews on CAR-T cell therapy have been limited in scope and methodology. Herein, we present a protocol for a systematic review to identify CAR-T cell interventional studies and examine the safety and efficacy of this therapy in patients with haematology malignancies and solid tumours.Methods and analysisWe will search MEDLINE, including In-Process and Epub Ahead of Print, EMBASE and the Cochrane Central Register of Controlled Trials from 1946 to 22 February 2017. Studies will be screened by title, abstract and full text independently and in duplicate. Studies that report administering CAR-T cells of any chimeric antigen receptor construct targeting antigens in patients with haematological malignancies and solid tumours will be eligible for inclusion. Outcomes to be extracted will include complete response rate (primary outcome), overall response rate, overall survival, relapse and adverse events. A meta-analysis will be performed to synthesise the prevalence of outcomes reported as proportions with 95% CIs. The potential for bias within included studies will be assessed using a modified Institute of Health Economics tool. Heterogeneity of effect sizes will be determined using the CochraneI2statistic.Ethics and disseminationThe review findings will be submitted for peer-reviewed journal publication and presented at relevant conferences and scientific meetings to promote knowledge transfer.PROSPERO registration numberCRD42017075331.
A mean-curvature flow along a Kähler–Ricci flow
Authors: Han Xiaoli , Li Jiayu , Zhao Liang 
Published: December 2017

Let [Formula: see text] be a Kähler surface, and [Formula: see text] an immersed surface in [Formula: see text]. The Kähler angle of [Formula: see text] in [Formula: see text] is introduced by Chern and Wolfson [Am. J. Math. 105 (1983) 59–83]. Let [Formula: see text] evolve along the Kähler–Ricci flow, and [Formula: see text] in [Formula: see text] evolve along the mean-curvature flow. We show that the Kähler angle [Formula: see text] satisfies the evolution equation [Formula: see text] where [Formula: see text] is the scalar curvature of [Formula: see text]. The equation implies that if the initial surface is symplectic (Lagrangian), then, along the flow, [Formula: see text] is always symplectic (Lagrangian) at each time [Formula: see text], which we call a symplectic (Lagrangian) Kähler–Ricci mean-curvature flow. In this paper, we mainly study the symplectic Kähler–Ricci mean-curvature flow.
WebRelate: integrating web data with spreadsheets using examples
Authors: Inala Jeevana Priya , Singh Rishabh 
Published: December 2017

Data integration between web sources and relational data is a key challenge faced by data scientists and spreadsheet users. There are two main challenges in programmatically joining web data with relational data. First, most websites do not expose a direct interface to obtain tabular data, so the user needs to formulate a logic to get to different webpages for each input row in the relational table. Second, after reaching the desired webpage, the user needs to write complex scripts to extract the relevant data, which is often conditioned on the input data. Since many data scientists and end-users come from diverse backgrounds, writing such complex regular-expression based logical scripts to perform data integration tasks is unfortunately often beyond their programming expertise.
We present WebRelate, a system that allows users to join semi-structured web data with relational data in spreadsheets using input-output examples. WebRelate decomposes the web data integration task into two sub-tasks of i) URL learning and ii) input-dependent web extraction. We introduce a novel synthesis paradigm called "Output-constrained Programming By Examples", which allows us to use the finite set of possible outputs for the new inputs to efficiently constrain the search in the synthesis algorithm. We instantiate this paradigm for the two sub-tasks in WebRelate. The first sub-task generates the URLs for the webpages containing the desired data for all rows in the relational table. WebRelate achieves this by learning a string transformation program using a few example URLs. The second sub-task uses examples of desired data to be extracted from the corresponding webpages and learns a program to extract the data for the other rows. We design expressive domain-specific languages for URL generation and web data extraction, and present efficient synthesis algorithms for learning programs in these DSLs from few input-output examples. We evaluate WebRelate on 88 real-world web data integration tasks taken from online help forums and Excel product team, and show that WebRelate can learn the desired programs within few seconds using only 1 example for the majority of the tasks.
What is decidable about string constraints with the ReplaceAll function
Authors: Chen Taolue , Chen Yan , Hague Matthew , Lin Anthony W. , Wu Zhilin 
Published: December 2017

The theory of strings with concatenation has been widely argued as the basis of constraint solving for verifying string-manipulating programs. However, this theory is far from adequate for expressing many string constraints that are also needed in practice; for example, the use of regular constraints (pattern matching against a regular expression), and the string-replace function (replacing either the first occurrence or all occurrences of a ``pattern'' string constant/variable/regular expression by a ``replacement'' string constant/variable), among many others. Both regular constraints and the string-replace function are crucial for such applications as analysis of JavaScript (or more generally HTML5 applications) against cross-site scripting (XSS) vulnerabilities, which motivates us to consider a richer class of string constraints. The importance of the string-replace function (especially the replace-all facility) is increasingly recognised, which can be witnessed by the incorporation of the function in the input languages of several string constraint solvers.
Recently, it was shown that any theory of strings containing the string-replace function (even the most restricted version where pattern/replacement strings are both constant strings) becomes undecidable if we do not impose some kind of straight-line (aka acyclicity) restriction on the formulas. Despite this, the straight-line restriction is still practically sensible since this condition is typically met by string constraints that are generated by symbolic execution. In this paper, we provide the first systematic study of straight-line string constraints with the string-replace function and the regular constraints as the basic operations. We show that a large class of such constraints (i.e. when only a constant string or a regular expression is permitted in the pattern) is decidable. We note that the string-replace function, even under this restriction, is sufficiently powerful for expressing the concatenation operator and much more (e.g. extensions of regular expressions with string variables). This gives us the most expressive decidable logic containing concatenation, replace, and regular constraints under the same umbrella. Our decision procedure for the straight-line fragment follows an automata-theoretic approach, and is modular in the sense that the string-replace terms are removed one by one to generate more and more regular constraints, which can then be discharged by the state-of-the-art string constraint solvers. We also show that this fragment is, in a way, a maximal decidable subclass of the straight-line fragment with string-replace and regular constraints. To this end, we show undecidability results for the following two extensions: (1) variables are permitted in the pattern parameter of the replace function, (2) length constraints are permitted.