bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methionine and vitamin B‐complex ameliorate antitubercular drugs‐induced toxicity in exposed patients
Authors: Amagon Kennedy I. , Awodele Olufunsho , Akindele Abidemi J. 
Published: September 2017

AbstractTuberculosis therapy utilizes drugs that while effective cause treatment‐related toxicity. Modulation of antitubercular drugs‐induced toxicity by methionine and vitamin B‐complex in patients was evaluated. 285 treatment‐naïve tuberculosis patients at the Chest Clinics of Infectious Diseases Hospital, Yaba and General Hospital, Lagos in Lagos, Nigeria was prospectively recruited and allotted into test (antitubercular medicines, methionine and vitamin B‐complex) and control groups (antitubercular medicines). Data on adverse drug reactions and blood samples were collected at initiation, 2 months and 6 months, and then analyzed. Red blood cells and packed cell volume were significantly higher (P < 0.05) in the test group compared to control at 6 months of therapy. At the end of 2 months, results showed a significant decrease (P < 0.001) in aspartate aminotransferase, alkaline phosphatase, alanine aminotransferase, urea, creatinine and total bilirubin in the test group compared to control. Reduced glutathione and superoxide dismutase were significantly increased (P < 0.001) and malondialdehyde significantly decreased (P < 0.001) in the test versus control groups at the end of 2 and 6 months. Adverse drug reactions were significantly lower (P < 0.001) in the test group (32.4%) compared to control group (56.2%), with 1 death. Hepatotoxicity was significantly higher (P = 0.026) in control (6.9%), compared to test group (0%). Alcohol and cigarette smoking were significantly (P = 0.019 andP = 0.027) associated with the occurrence of adverse drug reactions. Methionine and vitamin B‐complex modulated hepatic, renal, hematological, antioxidant indices and adverse effects in patients administered antitubercular medicines. Such interventions can enhance compliance and better treatment outcomes in tuberculosis patients.
Alternating landmark navigation of multiple AUVs for wide seafloor survey: Field experiment and performance verification
Authors: Matsuda Takumi , Maki Toshihiro , Sato Yoshiki , Sakamaki Takashi , Ura Tamaki 
Published: September 2017

AbstractThis paper reports the results of the sea experiments and the performance verification of a navigation method for wide area surveys of the seafloor using multiple autonomous underwater vehicles (AUVs). In the method, AUVs alternately land on the seafloor to act as landmarks for each other, and all AUVs can observe a wide area with accurate positioning relative to the landmark AUV. For self‐localization, AUVs are typically supported by long base line (LBL) or super short base line (SSBL) of the support system. Thanks to the proposed method, AUVs can perform near‐seafloor surveys requiring real‐time and accurate positioning, such as seafloor imaging and sampling, without these support systems. The method was implemented on two AUVs: “Tri‐Dog 1” and “Tri‐TON.” The performance of the method was verified using these AUVs through sea experiments and postprocessing simulation using experimental data. In addition, it was also verified that the performance of the method is comparable to high‐grade conventional navigation methods, such as LBL or SSBL, through simulations of long distance navigation.
R‐ADVANCE: Rapid Adaptive Prediction for Vision‐based Autonomous Navigation, Control, and Evasion
Authors: Escobar‐Alvarez Hector D. , Johnson Neil , Hebble Tom , Klingebiel Karl , Quintero Steven A. P. , Regenstein Jacob , Browning N. Andrew 
Published: September 2017

AbstractIn this article, we present a monocular visual reactive navigation system capable of navigating at high speeds, without GPS, in unknown complex cluttered environments. The system, called R‐ADVANCE (Rapid Adaptive Prediction for Vision‐based Autonomous Navigation, Control, and Evasion), consists of a set of biologically inspired visual perception and reactive control algorithms that provide low‐computation reactive obstacle avoidance while navigating at high speeds in search of a goal object. These algorithms, along with basic planning, and augmented with low‐precision visual odometry, were implemented on a micro unmanned aerial vehicle and tested in a number of challenging environments. While each of the individual algorithmic and hardware elements has been previously studied in limited environments, this work is the first time that these novel components have been integrated and flight‐tested. To achieve fast flight, an NVIDIA Tegra TK1 was used as the main processor, allowing us to parallelize the system to process 1280 × 720 video streams at 40 fps, reaching flight speeds up to 19 m/s (≈68 km/h) or 42 mph.
Palladium Nanoparticles Decorated Graphene Oxide: Active and Reusable Nanocatalyst for the Catalytic Reduction of Hexavalent Chromium(VI)
Authors: Celebi Metin , Karakas Kadir , Ertas Ilknur Efecan , Kaya Murat , Zahmakiran Mehmet 
Published: September 2017

AbstractToday, the catalytic reduction of Cr(VI) to Cr(III) stands one of the most important challenges in the environmental chemistry and catalysis due to highly stable, contaminant and toxic nature of Cr(VI). In this study, we show that a new nanocatalyst system comprised of 3‐aminopropyltriethoxysilane (APTS) stabilized palladium(0) nanoparticles grafted onto the surface of graphene oxide (Pd/GO) efficiently works in the catalytic reduction of Cr(VI) to Cr(III) under mild reaction conditions. Pd/GO nanocatalyst was reproducibly prepared through two‐steps procedure: (i) H2 reduction of Pd(dba)2 (dba=dibenzylideneacetone) in the presence of APTS in THF to synthesize colloidal APTS stabilized palladium(0) nanoparticles and then (ii) the deposition of 3‐aminopropyltriethoxysilane stabilized palladium(0) nanoparticles onto the surface of graphene oxide (GO) by impregnation. The characterization of Pd/GO was carried out by advanced analytical techniques. The summation of the results acquired from these analyses reveals that the formation of well‐dispersed and highly crystalline palladium(0) nanoparticles on the surface of GO. The catalytic performance of the resulting Pd/GO in terms of activity and stability was assessed in the catalytic reduction of Cr(VI) to Cr(III) in aqueous solution in the presence of formic acid (HCOOH) as a reducing agent. We found that Pd/GO nanocatalyst exhibits high activity (TOF=3.6 mol Cr2O72−/mol Pd×min) and reusability (> 90% at 5th reuse) in this catalytic transformation at room temperature.
Bioinspired Copper Coordination Polymer Catalysts for Oxygen Reduction Reaction
Authors: Mishra Rupali , Patil Bhushan , Karadaş Ferdi , Yılmaz Eda 
Published: September 2017

AbstractNon–noble metal catalysts have recently emerged as promising alternatives to the expensive platinum catalysts for the oxygen reduction reaction (ORR). In this study, a new domain of materials, copper based coordination polymers, has been investigated as promising catalysts for ORR. The study was inspired by copper incorporating biomolecules, which efficiently catalyse the oxygen reduction reaction in nature. Two coordination polymers, [Cu2(μ−AcO)4Po)]n (shortened as[Cu–A]) and [Cu2(μ−BzO)4Po)]n (shortened as[Cu–B]), incorporating one–dimensional chains of Cu(II) paddle wheel units bridged with phosphineoxide ligands were combined with multi−walled carbon nanotubes (MCNTs) to prepare hybrid electrocatalysts for ORR. The electrochemical analysis demonstrates that [Cu–A] catalyses ORR with 3.24 numbers of electrons with Tafel slopes of 122/83 mV dec−1 while it is 2.37 numbers of electrons with Tafel slopes of 131/84 mV dec−1 for [Cu–B]. Rotating disk electrode measurements and evaluation of Tafel slopes reveal that acetate moieties attached to Cu site shift the onset potential of ORR anodically (ca. 40 mV) compared to the one with benzoate bridging groups. The effect of bridging ligands to the stability and activity of catalysts in alkaline media was also evaluated. This study opens a new perspective for the development of non–platinum ORR catalysts.
Cobalt Complexes Catalyze Reduction of Nitro Compounds: Mechanistic Studies
Authors: Kumar Sushil , Gupta Rajeev 
Published: September 2017

AbstractMononuclear Co2+/3+ complexes of 13‐membered amide‐based macrocycles have been synthesized, characterized and utilized in the chemo‐selective reduction of assorted nitro compounds including aromatic, heterocyclic and aliphatic ones. Catalytic results illustrate that Co3+ complexes are better catalysts than the analogous Co2+ complexes while mechanistic investigations display the generation of an [(L)Co2+(μ‐NH2NH2)Co2+(L)] intermediate during the catalysis.
Highly Luminescent 4′‐(4‐ethynylphenyl)‐2,2’:6’,2’’‐Terpyridine Derivatives as Materials for Potential Applications in Organic Light Emitting Diodes
Authors: Zych Dawid , Slodek Aneta , Matussek Marek , Filapek Michał , Szafraniec‐Gorol Grażyna , Krompiec Stanisław , Kotowicz Sonia , Siwy Mariola , Schab‐Balcerzak Ewa , Bednarczyk Katarzyna , Libera Marcin , Smolarek Karolina , Maćkowski Sebastian , Danikiewicz Witold 
Published: September 2017

AbstractFour novel derivatives of 4’‐(4‐ethynylphenyl)‐2,2’:6’,2’’‐terpyridine with 7‐(N,N‐diphenylamino)‐9,9‐dioctylfluorene, 7‐(9H‐carbazo‐9‐yl)‐9,9‐dioctylfluorene, 9‐octyl‐9H‐carbazole, 6‐(9H‐carbazo‐9‐yl)‐9‐octylcarbazole substituents were obtained via Sonogashira cross‐coupling reaction and thoroughly characterized. DSC measurements demonstrated that prepared terpyridine derivatives are molecular glasses, which exhibited high thermal stability based on TGA analysis. Since they showed high photoluminescence (PL) quantum yields approaching 80% in solution, the electroluminescence ability of the compounds was tested in diodes in a guest‐host configuration. Upon dispersing in a matrix consisting of poly(9‐vinylcarbazole) (PVK) (50 wt %) and (2‐tert‐butylphenyl‐5‐biphenyl‐1,3,4‐oxadiazole) (PBD) (50 wt %), PL radiation with quantum yields in the range of 22–58% with maximum of emission band from 369 to 459 nm was observed, and the devices showed green or red electroluminescence. The results of the underline substantial role of the functional groups and the linker in the presented terpyridines in terms of their thermal, electrochemical, optical and electroluminescence properties. In addition, density functional theory (DFT) and time‐dependent‐density functional theory (TD‐DFT) calculations were performed to provide a deeper understanding of the experimental results.
A Non‐Perilous Coumarin‐Based Ratiometric Probe for ′In Vitro′ Detection of Cu through Cell Imaging Technique
Authors: Kumari Chanda , Sain Dibyendu , Kumar Ashish , Nayek Hari Pada , Debnath Sushanta , Saha Partha , Dey Swapan 
Published: September 2017

AbstractA novel coumarin based fluorescent turn on probe (R1) was designed and synthesized for ‘on the spot’ detection of biologically important Cu2+. The actual three dimensional geometry of the probe was confirmed by single crystal X‐ray analysis. R1 showed high sensitivity and selectivity towards Cu2+ without any intervention of other metal ions. Rapid naked eye detection of Cu2+ through colour change increased the superiority of the probe for practical use. Absorption and emission spectra proved the ratiometric detection ability of the probe towards Cu2+. Long wavelength visual fluorescence emission of the complex was utilized for intracellular detection of Cu2+ in living cells.
Nitrogen‐Doped Defective Graphene Aerogel as Anode for all Graphene‐Based Lithium Ion Capacitor
Authors: Wang Xin , Wang Zhenkun , Zhang Xin , Peng Huifen , Xin Guoqing , Lu Chengxing , Zhong Yuxiang , Wang Gongkai , Zhang Yongguang 
Published: September 2017

AbstractNitrogen‐doped defective graphene aerogel (N‐DGA) was prepared by a hydrothermal method incorporated with mild pore‐forming and post doping processes. The microstructure and electrochemical behavior were evaluated. The N‐DGA with relatively high‐level nitrogen content maintains a three‐dimensional (3D) interconnected structure, in which wrinkled graphene presents obvious in‐plane pores. The specific capacities of 1387 and 143 mAh g−1 could be achieved at current densities of 50 and 1000 mA g−1, respectively. The greatly improved electrochemical performance as the anode in contrast to that of the graphene aerogel (GA) without any structural modifications can be ascribed to the 3D microstructure, heteroatom doping and defect sites. These features endow the entire electrode with highly accessible surface area, improved conductivity, efficient ion transport and electrochemically active surface, which are beneficial to reversible lithium ion storage, rate capability as well as stability. The LICs full cell by using the N‐DGA anode and defective graphene aerogel/activated carbon (DGA/AC) cathode was assembled and the corresponding performance was also evaluated. The maximum energy and power densities of 39 Wh kg−1 and 1.2 kW kg−1 could be delivered. The descent performance shows a promising perspective of all graphene based LICs with high energy/power densities.
Two Cobalt(III) Schiff Base Complexes of the Type [Co(ABC)(DE)X]: Facile Synthesis, Characterization, Catechol Oxidase and Phenoxazinone Synthase Mimicking Activity
Authors: Ghosh Kousik , Harms Klaus , Chattopadhyay Shouvik 
Published: September 2017

AbstractTwo new mononuclear cobalt(III) Schiff base complexes with azide or thiocyanate [Co(L1)(L′)(N3)] (1) and [Co(L2)(L“)(NCS)] (2) {where HL1=2((2(piperidin‐1‐yl)ethylimino)methyl)‐6‐ethoxyphenol, HL2=2‐((3(dimethylamino)propylimino)methyl)‐6‐methoxyphenol, HL′=1‐acetyl‐2‐naphthol and HL”=2,4‐pentanedione} have been synthesized and characterized by single crystal X‐ray diffraction studies. Both complexes may be represented by a general formula: [Co(ABC)(DE)X], where ABC, DE and X represent tridentate, bidentate and monodentate ligands respectively. Both complexes are reactive towards the aerial oxidation of 3,5‐di‐tert‐butylcatechol (3,5‐DTBC) and o‐aminophenol (OAPH), and kinetics of the reactions are monitored spectrophotometrically. Analyses of the kinetic data reveal that complex 2 is better catalyst than complex 1 for both oxidation reactions. Tentative mechanistic implications of the catalytic oxidation reactions are also discussed. Mechanistic investigations of the catalytic behaviors indicate that the oxidation reactions proceed through catalyst‐substrate intermediates.
Bacterial Detection and Differentiation via Direct Volatile Organic Compound Sensing with Surface Enhanced Raman Spectroscopy
Authors: DeJong Caitlin S. , Wang David I. , Polyakov Aleksandr , Rogacs Anita , Simske Steven J. , Shkolnikov Viktor 
Published: September 2017

AbstractCurrent methods for detecting bacterial infections, such as culture and morphological analysis of bacterial colonies, are time and labor intensive. Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: Escherichia coli, Enterobacter cloacae, and Serratia marcescens. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of E. coli in under 12 hrs, and detected E. coli from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 103 CFU/ml and 104 CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point‐of‐care settings for diagnosing bacterial infections.
A New Series of Heteroleptic Cd(II) Diimine‐Ferrocenyl Dithiocarbamate Complexes which Successfully Co‐Sensitizes TiO2 Photoanode with Ru N719 Dye in DSSC
Authors: Manar Krishna K. , Neetu  , Anamika  , Srivastava Pankaj , Drew Michael G. B. , Singh Nanhai 
Published: September 2017

AbstractNew heteroleptic complexes of the form [Cd(diimine)(Fcdtc)2] (diimine= 1,10‐phenanthroline (phen), Fcdtc=N‐ferrocenyl‐N‐pyridin‐3‐ylmethyl dithiocarbamate (KL1) Cd1; 2,2’‐bipyridyl (bpy), N‐ferrocenyl‐N‐pyridin‐4‐ylmethyl dithiocarbamate (KL2) Cd2; bpy, (KL1) Cd3 and phen, (KL2) Cd4) have been synthesised and characterized by elemental analyses, spectroscopy (IR, UV‐Vis., 1H and 13C {1H} NMR) and their structures have been revealed by X‐ray crystallography. These complexes have been explored as co‐sensitizers with N719 over TiO2 for application as dye sensitized solar cells (DSSC) photoanodes. The use of these complexes as co‐sensitizers resulted in extended UV‐Visible spectral response, greater dye loading, enhanced electron life time, reduced charge recombination and thermodynamically more facile charge transfer in the DSSC. Among all the co‐sensitized cells (Cd1/N719, Cd2/N719, Cd3/N719 and Cd4/N719), the Cd1‐based cell demonstrated not only the highest incident photon to current efficiency (IPCE) 47% but the obtained current conversion efficiency 3.84%, was much higher than that of the N719 based cell (2.70%) under the same illumination condition.
Induced Piezoelectricity in Poly(vinylidene fluoride) Hybrid as Efficient Energy Harvester
Authors: Gaur Anupama , Kumar Chandan , Shukla Rahul , Maiti Pralay 
Published: September 2017

AbstractPoly(vinylidene fluoride) (PVDF) nanohybrid with organically modified two‐dimensional nanoclay, prepared through solution route, has been fabricated as the energy harvester. The nanoclay induces piezoelectric phase in PVDF arising from epitaxial crystallization over the nanoclay layers. Further enhancement of piezoelectricity has been made by stretching the film at high temperature showing ∼80% β‐phase along with some γ‐phase in nanohybrid. Orientation of the nanofiller along the force field creates the nanohybrid tougher and suitable for device fabrication. Mapping of piezo‐domain has been constructed through piezo force microscopy indicating 100 nm dimension of the electroactive phase in stretched nanohybrid as opposed to almost zero size in pure PVDF. Structural alteration has also been confirmed through spectroscopic and thermal measurements. Morphology also supports the formation of β‐phase in presence of nanoparticle (spherulite to needle like morphology). The piezoelectric coefficient shows a significant increase after processing due to greater piezoelectric phase and the fabrication of unimorph has been made using high piezoelectric coefficient material showing higher peak to peak voltage generation of 2.5 V with much longer response time (6 ms) in stretched nanohybrid under an impulse load. Finally, the voltage and current output from the devices are measured under varying load and highest power density value of 25 μW/cm3 is obtained for stretched nanohybrid, more than sufficient to operate a miniature self‐powering device.
Early Versus Delayed Source Control in Open Abdomen Management for Severe Intra‐abdominal Infections: A Retrospective Analysis on 111 Cases
Authors: Rausei Stefano , Pappalardo Vincenzo , Ruspi Laura , Colella Antonio , Giudici Simone , Ardita Vincenzo , Frattini Francesco , Rovera Francesca , Boni Luigi , Dionigi Gianlorenzo 
Published: September 2017

AbstractBackgroundTime to source control plays a determinant prognostic role in patients having severe intra‐abdominal infections (IAIs). Open abdomen (OA) management became an effective treatment option for peritonitis. Aim of this study was to analyze the correlation between time to source control and outcome in patients presenting with abdominal sepsis and treated by OA.MethodsWe retrospectively analyzed 111 patients affected by abdominal sepsis and treated with OA from May 2007 to May 2015. Patients were classified according to time interval from first patient evaluation to source control. The end points were intra‐hospital mortality and primary fascial closure rate.ResultsThe in‐hospital mortality rate was 21.6% (24/111), and the primary fascial closure rate was 90.9% (101/111). A time to source control ≥6 h resulted significantly associated with a poor prognosis and a lower fascial closure rate (mortality 27.0 vs 9.0%, p = 0.04; primary fascial closure 86 vs 100%, p = 0.02). We observed a direct increase in mortality (and a reduction in closure rate) for each 6‐h delay in surgery to source control.ConclusionEarly source control using OA management significantly improves outcome of patients with severe IAIs. This damage control approach well fits to the treatment of time‐related conditions, particularly in case of critically ill patients.
Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC-06)
Authors: Kimura Yutaka , Fujii Masashi , Masuishi Toshiki , Nishikawa Kazuhiro , Kunisaki Chikara , Matsusaka Satoshi , Segawa Yoshihiko , Nakamura Masato , Sasaki Kinro , Nagao Narutoshi , Hatachi Yukimasa , Yuasa Yasuhiro , Asami Shinya , Takeuchi Masahiro , Furukawa Hiroshi , Nakajima Toshifusa ,   on behalf of the JACCRO GC-06 Study Group, Kawase Tomono , Kawabata Ryohei , Kimura Yutaka , Etou Tetsuya , Masuishi Toshiki , Makino Hirochika , Ono Hidetaka , Izumisawa Yusuke , Kunisaki Chikara , Nishikawa Kazuhiro , Kawada Junji , Matsusaka Satoshi , Shimada Ken , Sunakawa Yu , Segawa Yoshihiko , Nakamura Masato , Satomura Hitoshi , Sasaki Kinro , Nagao Narutoshi , Kunieda Katsuyuki , Tsuji Akihito , Satake Hironaga , Hatachi Yukimasa , Ishikura Hisashi , Yuasa Yasuhiro , Okitsu Hiroshi , Asami Shinya , Ito Takahiro , Moriichi Kentaro , Takahashi Masazumi , Takinishi Yasutaka , Sekikawa Takashi , Okumura Naoki , Ueyama Shigemitsu , Yamamura Noriyuki , Manaka Dai , Oouchi Sachiko , Ohashi Ryuichiro , Mannami Tomohiko , Tanabe Kazuaki , Shiraishi Takeshi 
Published: September 2017

Abstract
Background
S-1 plus cisplatin is a standard regimen for advanced gastric cancer (AGC) in Asia. The ToGA trial established a fluoropyrimidine plus cisplatin and trastuzumab as a standard treatment for human epidermal growth factor receptor 2 (HER2)-positive AGC. In the HERBIS-1 trial, trastuzumab combined with S-1 plus cisplatin showed promising antitumor activity in patients with HER2-positive AGC. However, cisplatin has several important drawbacks, including vomiting and renal toxicity. These disadvantages of cisplatin are prominent in elderly patients. Therefore, we conducted a prospective phase II study of trastuzumab plus S-1 without cisplatin in elderly patients with HER2-positive AGC.

Methods
Patients 65 years or older who had HER2-positive AGC received S-1 orally on days 1–28 of a 42-day cycle and trastuzumab intravenously on day 1 of a 21-day cycle.

Results
A total of 51 patients were enrolled. Two patients were ineligible. The full analysis set thus comprised 49 patients. The median age was 71 years (range 65–85). The confirmed response rate was 40.8% (95% CI 27.1–54.6%), and the null hypothesis was rejected. The median follow-up period was 10.6 months. Median overall survival was 15.8 months. Median progression-free survival was 5.1 months, and time to treatment failure was 4.0 months. Major grade 3 or 4 adverse events included neutropenia (12.0%), anemia (24.0%), diarrhea (10.0%), and anorexia (12.0%). There was one treatment-related death.

Conclusions
Trastuzumab in combination with S-1 alone demonstrated promising antitumor activity and manageable toxic effects as well as promising survival results in elderly patients with HER2-positive AGC.

Clinical trials registration
UMIN000007368.