bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon-inducible miR-128 modulates HIV-1 replication by targeting TNPO3 mRNA
Authors: Bochnakian Aurore , Zisoulis Dimitrios G , Idica Adam , Zhen Anjie , KewalRamani Vineet N , Daugaard Iben , Hamdorf Matthias , Kitchen Scott , Lee KyeongEun , Pedersen Irene Munk 
Published: September 2017

ABSTRACTThe HIV/AIDS pandemic remains an important threat to human health. We have recently demonstrated that a novel microRNA (miR-128) represses retrotransposon (LINE-1 or L1) by a dual mechanism, by directly targeting the coding region of the L1 RNA and by repressing a required nuclear import factor (TNPO1). We have further determined that miR-128 represses the expression of all three isoforms of TNPO proteins (transportins, TNPO1,-2 and TNPO3). Here, we establish that miR-128 also controls HIV-1 replication by repressing TNPO3. TNPO3 is well established to regulate HIV-1 nuclear import and viral replication. Here, we report that the type I interferon inducible miR-128 directly targets two sites in the TNPO3 mRNA, significantly down-regulating TNPO3 mRNA and protein expression levels. Manipulation of miR-128 levels in HIV target cell lines and in primary human CD4 T-cells by over-expression or knockdown showed that modulation of TNPO3 by miR-128 affects HIV-1 replication but not MLV infection. In addition, we found that miR-128 modulation of HIV-1 replication is reduced with TNPO3-independent HIV-1 virus and in cells depleted of CPSF6, suggesting that miR-128-indued TNPO3 repression is partly required for miR-128-induced inhibition of HIV-1 replication. Finally, challenging miR-modulated Jurkat cells or primary CD4 T-cells with wildtype, replication-competent HIV-1 shows that miR-128 significantly delays spreading infection. Thus, we have established a novel role of miR-128 in anti-viral defense in human cells, inhibiting HIV-1 replication partly by targeting TNPO3.
Intellectual capital and competitive advantage in Uganda’s microfinance industry
Authors: Kamukama Nixon , Sulait Tumwine 
Published: September 2017

Purpose
The paper examines individual contribution of intellectual capital elements to competitive advantage. The purpose of this paper is to explore the weight of individual intellectual capital elements in explaining competitive advantage in Uganda’s microfinance industry.

Design/methodology/approach
Hierarchical regression was used because of its capacity to indicate precisely what happens to the model as different predictor variables are introduced.

Findings
This study confirms that the three intellectual capital elements are the strong predictors of competitive advantage and they account for 44 percent of variance in competitive advantage. However, the order of importance of these variables in explaining the variance in competitive advantage in the microfinance industry (basing on their standardized β values) is relational capital, structural capital and human capital.

Research limitations/implications
Only a single research methodological approach was employed and future research through interviews could be undertaken to triangulate the data. Furthermore, the findings from the present study are cross-sectional; future research should be undertaken to examine the longitudinal effects of intellectual capital elements.

Practical implications
The findings can help the management to intensify initiatives to encourage greater understanding and acceptance of the concept of intellectual capital that boosts competitive edge in the industry.

Originality/value
This is the first study that focuses on testing the individual contribution of intellectual capital dimensions to competitive advantage in Uganda’s microfinance institutions.
Financial sector development and income inequality in South Africa
Authors: Kapingura Forget Mingiri 
Published: September 2017

PurposeThe purpose of this paper is to examine the relationship between financial sector development and inequality in South Africa for the period from 1990 to 2012. Unlike previous studies, the study examines the role of both the broad measure of financial sector development (Bank credit to the private sector) and a measure of financial inclusion (ATMs).Design/methodology/approachUtilising quarterly data, the autoregressive distributed lag bounds testing model approach to cointegration test was estimated. The approach was preferred due to its compatibility with data of different orders and flexibility.FindingsThe findings indicate that financial development, especially when it is inclusive reduces the level of inequality in South Africa both in the short- and long-run. The results also highlighted that economic growth, external trade activities and government activities have played a very important role in reducing inequality in South Africa. On the other hand the empirical results also highlight that increasing inflation is regressive on inequality in South Africa.Research limitations/implicationsThe results from the study imply that financial development on its own though important may not benefit the disadvantaged groups such as the poor and the rural community until it is inclusive. It is important to note that the study was carried out on the premise that inequality plays a very important role in exacerbating poverty levels in South Africa.Practical implicationsThe paper highlights another avenue which authorities can pursue to reduce the level of inequality in the country.Social implicationsThe paper documents the importance of financial inclusion in reducing the level of inequality in South Africa rather than advocating for financial sector development only.Originality/valueThe paper makes a contribution through analysing the effect of financial inclusion on income inequality rather than broad financial sector development which is common to the majority of the available empirical studies.
Employer assessments of business interns
Authors: Rothman Miriam 
Published: September 2017

Purpose
A 2012 international survey by McKinsey & Co. reported a schism among higher education providers, employers and youth in regard to their perception about graduates’ adequate preparation for employment. They suggested greater engagement among stakeholders as a way to bridge this gap. The purpose of this paper is to suggest that academic credit-based internship programs can aid in the engagement process through better utilization of employer evaluations of interns.

Design/methodology/approach
Supervisors (n=389) rated their business interns on 12 competencies and responded to three open-ended questions about their strengths, weaknesses and recommendations for professional improvement. Rating scale data were averaged by item and a content analysis methodology was used to analyze the questionnaire responses.

Findings
The average score for each of the 12 rated items was fairly high and reflected competencies associated with the school to work transition, communication skills, decision making and work ethic. Responses to the open-ended questions yielded eight themes that were noted as strengths for some interns but weaknesses for others. About 30 percent of supervisors made recommendations for professional improvement of the intern.

Originality/value
There is a dearth of studies reporting results of actual employer evaluations of interns. Not only does this study address this gap through data collection from 389 supervisors across a variety of business functions, but also clarifies these ratings for individual career development through identifying interns’ strengths, weaknesses and advice for professional improvement. By collecting outcome assessments on interns from supervisors, higher education providers can not only identify the strengths and weaknesses of their curricula, but also their soon-to-be graduates; and provide support and resources for performance improvement. Interns too become aware of competencies identified for successful labor market integration.
Transforming the student-learning experience: the Triple-V model of experiential learning
Authors: Mortimer Sue 
Published: September 2017

Purpose
The purpose of this paper is to demonstrate how the Triple-V model of experiential learning, when applied to Higher Education (HE), can transform the student-learning experience by integrating the model’s three elements of Vision, Value and Vocation into delivery, assessment and beyond.

Design/methodology/approach
The paper sets out how the Triple-V model was introduced in three case studies. Feedback data were gathered through formal and informal surveys with students and other respondents.

Findings
The Triple-V model expounds the virtues of integrating Vision, Value and Vocation into HE to engage students in deep learning and to provide an external employability reference framework, which is particularly vital for students leaving HE with concerns about securing suitable employment to service soaring levels of student debt. The implementation of the model, based on measured outcomes, met with positive feedback from respondents.

Research limitations/implications
The Triple-V model was tested across three scenarios, using different respondents, within a School of Management. A Twitter account has been established (#triple_v_model) to invite wider participation and feedback to hone the model further, in particular its suitability for more esoteric, and less exoteric, subjects.

Originality/value
The Triple-V model is entirely original, devised by the present author, and is intended to enhance the HE student learning experience, contextualising for students their studies within a wider employability framework.
Challenges and opportunities for the development and promotion of Ibaloy crafts as tourism products
Authors: Ona Jamaica Gayatin , Solis Leticia Susan Lagmay 
Published: September 2017

Purpose
The Ibaloy is an indigenous ethnic group in the Northern Philippines. Due to modernization, changes in lifestyle, livelihood and spiritual inclination many have forgotten about their culture. Income-generating activities such as handicraft businesses and food security are among their needs and aspirations. With the potential that indigenous entrepreneurship has in improving their cultural and economic status, this study aims to identify which crafts in their material culture can be publicly shared as tourism products and to assess the landscape within which indigenous entrepreneurship can be undertaken.

Design/methodology/approach
The study utilized a qualitative methodology which involved a combination of participant observation and semi-structured interviews. An interview guide which consisted of open-ended questions that focused on themes such as identification of Ibaloy crafts, the crafts’ various categorization and significance, the challenges and opportunities and their perceptions on what they want done for their crafts and material culture in general was developed for this purpose. The primary respondents were the Ibaloys themselves and other key informants from government and other stakeholders.

Findings
Other than serving their purpose in an Ibaloy household and as objects used for special occasions, Ibaloy crafts have the potential to be developed as tourism products. While many challenges abound, availability of resources and collaborative support by the government and other institutions can bring opportunities that will lead Ibaloy crafts to become prime tourism products.

Social implications
The findings point to a compelling need for policymakers and concerned authorities to take immediate action to ensure the culture and heritage of the Ibaloys are protected.

Originality/value
The study adds to the literature about Filipino indigenous peoples, particularly the Ibaloys of Cordillera, and their aspirations for the inclusion of their material culture to the tourism industry. It can serve as a guide in addressing issues and concerns related to indigenous entrepreneurship that may be addressed through policy intervention and support from stakeholders.
The clinical governance of multidisciplinary care
Authors: Pearson Ben 
Published: September 2017

Purpose
Providers of health and social care services aim to deliver personalised care that is safe, effective, caring, responsive and well led. Multidisciplinary teams often have to work together, either within or across multiple provider organisations in order to achieve this aim. It is valuable to have a framework of clinical governance for such circumstances that enables a shared assurance of quality. To achieve these aims, the purpose of this paper is to present a clinical governance matrix framework developed by the author’s experiences in clinical practice, in service change and in management and leadership.

Design/methodology/approach
There are seven pillars of clinical governance; patient and public involvement, staffing and staff management, clinical effectiveness and research, using information and IT, education and training, risk management and audit. These seven pillars of clinical governance can be mapped against the five quality domains of safe, effective, caring, responsive and well led to create a matrix that in turn describes the framework we need for quality assurance.

Findings
The matrix is populated with outcome measures and these are monitored to achieve balance across the framework. The tool can be used at the level of an individual practitioner all the way up to multiple organisations in collaboration. The detail in each cell of the matrix will change accordingly and critically should be developed and owned by the subject of the framework.

Originality/value
This clinical governance matrix is presented as a methodology to monitor quality assurance in the settings of health and social care.
Sustainability-related risk management in buying logistics services
Authors: Multaharju Sirpa , Lintukangas Katrina , Hallikas Jukka , Kähkönen Anni-Kaisa 
Published: September 2017

Purpose
Sustainability-related risk management of logistics service providers (LSPs) is an essential part of sustainability performance of focal companies, as logistics services touch the entire supply chain (SC) – from raw material sources to end-customers. The purpose of this paper, draws on resource-based view and stakeholder theory in exploring how companies can manage environmental and social sustainability-related risks from logistics service suppliers. This kind of capability is essential in order to maintain reputation in the eyes of stakeholders, and to maintain long-term financial performance.

Design/methodology/approach
The data of this multiple-case study were collected from semi-structured interviews in eight case-companies in Finland. Five of the cases are primary logistics buyers, and three represent LSP companies.

Findings
The cross-case analysis showed that primary buyers of logistics services use their sustainability criteria as a prerequisite for LSP candidates, and when the level is adequate and equal, other factors, e.g. price and capacity, are decisive. Based on the analysis, large LSPs are preparing for the future competition, and act in a more sustainable manner than their customers (buyers) expect at the moment, while small LSPs strictly comply with the regulation. However, buyers’ requirements for sustainable logistics services are increasing as the stakeholder expectations for comprehensively sustainable SCs are growing.

Originality/value
Only little research has been conducted on sustainable logistics from the buyer company’s risk management perspective. This paper adds the knowledge of sustainability-related risk management in purchasing of logistics services and in the logistics industry.
Buyer and supplier perspectives on environmental initiatives
Authors: Murfield Monique Lynn , Tate Wendy L. 
Published: September 2017

PurposeThe purpose of this paper is to examine managerial perspectives in both buyer and supplier firms implementing environmental initiatives in their supply chains, and explore the impact of environmental initiatives on buyer-supplier relationships.Design/methodology/approachA qualitative, grounded theory approach is used as the methodological approach to this research, including 15 in-depth interviews with managers from buyer and supplier firms implementing environmental initiatives in their supply chains to gain multiple perspectives of the buyer-supplier relationships.FindingsThe results suggest that implementing environmental initiatives within the supply chain changes the buyer-supplier relationship from transactional to collaborative, shifting from a commodity-focused purchase to a more strategic purchase as environmental initiatives are implemented.Research limitations/implicationsAlthough both buyer and supplier perspectives were considered, matched dyads were not used; researchers should continue to provide a holistic perspective of the phenomenon with dyadic data. Additionally, the use of a qualitative research approach suggests a lack of generalizability of results, and therefore researchers should further test the propositions.Practical implicationsImplementing environmental initiatives within the supply chain may require different approaches to supply management and development for long-term success. Suppliers should recognize that the capability to implement environmental initiatives with their customers is a differentiator. The nuances involved in managing the implementation of environmental initiatives between firms can be better managed by collaboratively developing metrics specifically related to the environment.Originality/valuePrevious research in environmental supply chain management has examined drivers and barriers of implementing environmental initiatives with suppliers, but fails to address the relationship dynamics involved when implementing environmental initiatives between organizations. This research begins to fill that gap.
Modeling and forecasting oil price risk: the role of implied volatility index
Authors: Dutta Anupam 
Published: September 2017

Purpose
While numerous empirical studies have tried to model and forecast the oil price volatility over the years, such attempts using the crude oil volatility index (OVX) rarely exist. In order to conceal this void, the purpose of this paper is to investigate whether including OVX in the realized volatility (RV) models improve the accuracy of predictions.

Design/methodology/approach
At the empirical stage, the authors employ several measures to frame the RV of crude oil futures returns. In particular, the authors use three different range-based RV estimators recommended by Parkinson (1980), Rogers and Satchell (1991) and Alizadeh et al. (2002), respectively.

Findings
The findings reveal that the information content of crude OVX helps to provide more accurate volatility predictions in comparison to the base-line RV model which contains only historical oil volatilities. Besides, the forecast encompassing test further suggests that the modified RV model (when OVX is introduced in the base-line RV model) forecast encompasses the conventional RV forecast in majority of the cases.

Practical implications
Since forecasting oil price volatility plays a vital role in portfolio optimization, derivatives pricing, optimum asset allocation decisions and risk management, the findings of this study thus carry important implications for energy economists, investors and policymakers.

Originality/value
This paper adds to the existing literature, since it is one of the initial studies to explore whether OVX is informative about the realized variance of the US oil market returns. The findings recommend that the information content of oil implied volatilities should be taken into account when modeling the US oil market volatility. In addition, range-based measures should be utilized while estimating the RV.
Recovery and dementia: promoting choice and challenging controversy
Authors: Hammond Laura Louise , Debney Conrad 
Published: September 2017

Purpose
The purpose of this paper is to provide a viewpoint about why people with dementia should be able to choose Recovery and how this approach might be experienced by them.

Design/methodology/approach
This paper addresses some key challenges to accepting Recovery as an approach for people with dementia by making comparisons with people with mental health difficulties. It then discusses key concepts of Recovery using the connectedness, hope, identity, meaning and empowerment framework and how each one might be experienced by the person with dementia.

Findings
The challenges which cause concerns about the applicability of Recovery to people with dementia are shared by people with mental health difficulties, therefore Recovery should be perceived as an approach suitable for anyone regardless of their diagnosis. Recovery for people with dementia could mean: connecting to the self, others and the world to promote feelings of purposefulness; having hope for the here and now; preserving one’s identity; finding meaning in retaining skills and incorporating dementia into one’s life; and, feeling empowered by keeping one’s mind working, adopting a positive attitude, having control and making decisions.

Practical implications
People with dementia can choose to access Recovery, and commonly voiced concerns can be answered and supported with evidence.

Originality/value
This is one of the only papers written to provide an understanding of how Recovery might be experienced by people living with dementia, and directly answers some concerns.
The brand personalities of brand communities: an analysis of online communication
Authors: Paschen Jeannette , Pitt Leyland , Kietzmann Jan , Dabirian Amir , Farshid Mana 
Published: September 2017

Purpose
Online brand communities provide a wealth of insights about how consumers perceive and talk about a brand, rather than what the firm communicates about the brand. The purpose of this paper is to understand whether the brand personality of an online brand community, rather than of the brand itself, can be deduced from the online communication within that brand community.

Design/methodology/approach
The paper is empirical in nature. The authors use community-generated content from eight online brand communities and perform content analysis using the text analysis software Diction. The authors employ the five brand personality dictionaries (competence, excitement, ruggedness, sincerity and sophistication) from the Pitt et al. (2007) dictionary source as the basis for the authors’ analysis.

Findings
The paper offers two main contributions. First, it identifies two types of communities: those focusing on solving functional problems that consumers might encounter with a firm’s offering and those focusing on broader engagement with the brand. Second, the study serves as a blueprint that marketers can adopt to analyze online brand communities using a computerized approach. Such a blueprint is beneficial not only to analyze a firm’s own online brand community but also that of competitors, thus providing insights into how their brand stacks up against competitor brands.

Originality/value
This is the first paper examining the nature of online brand communities by means of computerized content analysis. The authors outline a number of areas that marketing scholars could explore further based on the authors analysis. The paper also highlights implications for marketers when establishing, managing, monitoring and analyzing online brand communities.