bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-R Model Calculations in Recombining Plasmas: Population Inversions in Ca17+, Ti19+ and Cu26+ Lithium-Like Ions
Authors: Sureau A. , Guennou H. , Möller C. 
Published: July 2016

AbstractRelated to the investigations on XUV lasers, this work presents results obtained by a collisional radiative model previously used for Al10+and S13+. The interest of the heavier elements which are considered here (Ca, Ti, Cu) is manifold. In particular, the wavelengths of some transitions between the inverted–population levels are below the carbon absorption edge, which is suitable for organic material investigations. Our results give information about the population inversions which may be expected according to the density and temperature conditions of the plasma concerned. Comparisons with existing experimental results are discussed in the copper case.
Theoretical and Experimental Investigation of the Satellite Structure of 1s2 1S° − ls3p 1P1 Line in He-Like Ions
Authors: Aglistkii E.V. , Panin A.N. , Safronova U.I. , Ulitin S.A. , Vainshtein L.A. , Mikhailov Y.A. , Rode A.V. , Skliskov G.V. , Cornille M. , Dubau J. , Loulergue M. , Faucher P. , Bely-Dubau F. 
Published: July 2016

AbstractSatellite lines of the He-like second resonance lines (i.e. 1s2− 1s3p) of P, K, Fe, Cu are studied. The spectral resolution of P is better than those of K, Fe, Cu, obtained by a different experimental set-up. The atomic parameters, required for the spectral analysis and obtained by two different theoretical methods, are compared.
Temperature Diagnostics from Dielectronic Satellites to the 1s1/2 −2p1/2 Ar XVIII Line in Tokamak Plasmas
Authors: Bombarda F. , Giannella R. , Lion J. , Volonté S. , Cornille M. , Dubau J. , Loulergue M. , Bely-Dubau F. , Faucher P. 
Published: July 2016

AbstractThe hydrogen-like Argon Ly-αdoublet and associated dielectronic satellites have been observed in the Frascati Tokamak (FT) after injection of Ar impurities in a deuterium plasma. The atomic data of the lines have been computed for n = 2 − 5 with AUTOLSJ. The unresolved satellites n = 5 − 15 have also been included. Comparison with experimental spectra provide good temperature diagnostics.
From Passive Support Systems to the NTT Active Support
Authors: Wilson R.N. , Franza F. , Noethe L. 
Published: July 2016

ESO has two telescope projects: the NTT (New Technology Telescope) with 3.5 m aperture and the VLT (Very Large Telescope) with 16 m equivalent aperture. The former is already in the engineering phase and should be completed in 1987; the latter is still in the study phase and will be described at this conference by our colleague, D. Enard.This paper is concerned with the primary support system of the NTT. The basic principles and layout of this support have already been described in the literature 1,2,3).
ESO's New Technology Telescope (NTT) Metallic Primary Mirror Project
Authors: Mischung K.N. 
Published: July 2016

AbstractESO has investigated the technological feasibility of a metallic primary mirror for the NTT. A brief status report is given indicating that a nickel coated aluminum or aluminum-alloy mirror blank can be manufactured within 15-18 months at costs well below those for a glass or ceramic material of identical shape and dimensions.
Two PopII Cepheids in the Globular Cluster M10
Authors: Clement C. , Sawyer Hogg H. , Lake K. 
Published: July 2016

The globular cluster Messier 10 has three known variables. The first two of these were discovered by one of us (Sawyer 1933) and the third by Arp (1955). Two of the variables, V2 (P=18.7226) and V3 (P=7.831), are population II cepheids while V1 appears to be an irregular variable. Another star which lies in the Schwarzschild gap on the horizontal branch is a suspected variable (Voroshilov 1971).In this investigation, we examine the variations in the periods of the two cepheids over the interval 1912 to 1983 (for V2) and 1931 to 1983 (for V3). The study is based on photographs obtained with seven different telescopes - the Mt.Wilson 100-inch and 60-inch (1912 to 1919), the Dominion Astrophysical Observatory 72-inch, the David Dunlap 74-inch and 19-inch, the 16-inch at the University of Toronto downtown campus and the University of Toronto 24-inch at the Las Campanas Observatory of the Carnegie Institution of Washington. Some of our magnitudes have already been published (Sawyer 1938) and the remaining ones will be submitted to the Astronomical Journal for publication. We have also included material published by Arp (1955, 1957) in our study.
Chemical Theories on the Origin of Comets
Authors: Yamamoto Tetsuo 
Published: July 2016

AbstractFirstly, observational data available at present to infer physical conditions of the formation environment of cometary matter are briefly surveyed. These include the chemical and isotopic composition of cometary matter, and the nuclear spin temperature derived from the ortho/para abundance ratio of H2O molecules. Secondly, theories on the origin of comets—theories based upon the chemical composition of the volatile component of cometary matter—are reviewed. The theories are classified into two types, distinguished by whether cometary volatiles originate as solar nebula condensates or as the sublimation residue of interstellar ices. Observational items helpful to test the theories are pointed out. Thirdly, discussion is given on the physical properties of ices relevant to the chemical theory of the origin of comets.
XVIII. Account of a Flag representing the Introduction of the Caste of Chalias or Cinnamon-peelers, into Ceylon
Authors: Johnston Alexander 
Published: July 2016

I beg leave to send you an account of the painting upon cloth which I presented to the Society some time ago, and which is a fac-simile of a very ancient banner of the caste of Chalias, or cinnamon-peelers, on the island of Ceylon.The present numbers and importance of these people, render their history a subject of curious research. As the Cingalese inhabitants of Ceylon were, previous to the thirteenth century, ignorant of the art of weaving fine cloth, which was then known to the Hindu inhabitants of the peninsula of India, the kings of Kandy offered great rewards to any of their subjects who would bring over from the peninsula some weavers for the purpose of introducing that art into Ceylon.
Some Considerations in the Theories of Combinations, Probabilities, and Life Contingencies
Authors: Hardy Peter 
Published: July 2016

My object in the following paper is to give, in a few leading problems, a general and somewhat elementary view of the Theory of Probabilities, exhibiting the immediate dependence of the doctrine of Life Contingencies on the laws of probability and combination, and showing how apparently complicated problems, involving two and three lives, can be deduced directly from their very simplest and most elementary forms of expression.From the nature of the subject-matter proposed to be treated, it will be at once perceived, that this paper is intended rather for the instruction of the student in this branch of mathematical analysis, than for the use of the proficient; and I claim for it no higher distinction.
Basolateral amygdala nucleus responses to appetitive conditioned stimuli correlate with variations in conditioned behaviour
Authors: Lee Seung-Chan , Amir Alon , Headley Drew B. , Haufler Darrell , Pare Denis 
Published: July 2016

AbstractIn the lateral amygdala (LA), training-induced increases in neuronal responsiveness to conditioned stimuli (CSs) reflect potentiated sensory responses that drive conditioned behaviours (CRs) via LA’s targets. The basolateral nucleus of the amygdala (BL) receives LA inputs and projects to various subcortical sites that can drive aversive and appetitive CRs. Consistent with this, BL neurons also develop increased responses to CSs that predict rewarding or aversive outcomes. This increased BL activity is thought to reflect the potentiated sensory responses of LA neurons. Here we contrast the CS-related activity of BL neurons when rats produced the expected CR or not, to show that cells activated by appetitive CSs mainly encode behavioural output, not CS identity. The strong dependence of BL activity on behaviour irrespective of CS identity suggests that feedforward connectivity from LA to BL can be overridden by other BL inputs.
The frequency of, and adherence to, single maintenance and reliever therapy instructions in asthma: a descriptive analysis
Authors: DiSantostefano Rachael L , Boudiaf Nada , Stempel David A , Barnes Neil C , Greening Andrew P 
Published: July 2016

AbstractInhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fixed-dose combinations are recommended regular maintenance options for asthma. ICS/LABAs containing formoterol may also be indicated for single maintenance and reliever therapy (SMART). This analysis evaluated the frequency of SMART dosing of budesonide/formoterol fixed-dose combination (BFC) in the United Kingdom. Secondary objectives were to assess adherence and use of short-acting ß2-agonists (SABAs). This was a descriptive analysis of treatment patterns using the UK Clinical Practice Research Datalink-GP OnLine Database data (2009–2013). SMART dosing was determined when prescription instructions contained guidance for daily dosing plus ‘and when required’. Treatment and prescription refill patterns of BFC and SABA were described in the year following the index date to identify adherence and SMART dosing instructions versus other dosing regimens. Of 14,818 patients identified, 173 (1.2%) had evidence of prescriptions for SMART dosing at their index BFC prescription. Despite being prescribed SMART dosing, 91 of 173 patients (53%) were additionally dispensed SABA in the year following the index date. The mean number of BFC inhalers used was less than required for daily treatment for SMART and non-SMART dosing groups (4.7 and 4.8, respectively).This analysis suggests that SMART dosing is infrequent when examining dosing instructions. Therefore, results of randomised clinical trials using SMART dosing may not translate to clinical practice in the United Kingdom because of the low level of SMART prescription, concurrent use of SABA, and inadequate refill persistence observed. Further research is needed to understand SMART dosing in real-world clinical practice.
The intrinsic defect structure of exfoliated MoS2 single layers revealed by Scanning Tunneling Microscopy
Authors: Vancsó Péter , Magda Gábor Zsolt , Pető János , Noh Ji-Young , Kim Yong-Sung , Hwang Chanyong , Biró László P. , Tapasztó Levente 
Published: July 2016

AbstractMoS2 single layers have recently emerged as strong competitors of graphene in electronic and optoelectronic device applications due to their intrinsic direct bandgap. However, transport measurements reveal the crucial role of defect-induced electronic states, pointing out the fundamental importance of characterizing their intrinsic defect structure. Transmission Electron Microscopy (TEM) is able to image atomic scale defects in MoS2 single layers, but the imaged defect structure is far from the one probed in the electronic devices, as the defect density and distribution are substantially altered during the TEM imaging. Here, we report that under special imaging conditions, STM measurements can fully resolve the native atomic scale defect structure of MoS2 single layers. Our STM investigations clearly resolve a high intrinsic concentration of individual sulfur atom vacancies and experimentally identify the nature of the defect induced electronic mid-gap states, by combining topographic STM images with ab intio calculations. Experimental data on the intrinsic defect structure and the associated defect-bound electronic states that can be directly used for the interpretation of transport measurements are essential to fully understand the operation, reliability and performance limitations of realistic electronic devices based on MoS2 single layers.
Bio-Inspired Miniature Direction Finding Acoustic Sensor
Authors: Wilmott Daniel , Alves Fabio , Karunasiri Gamani 
Published: July 2016

AbstractA narrowband MEMS direction finding sensor has been developed based on the mechanically coupled ears of the Ormia Ochracea fly. The sensor consists of two wings coupled at the middle and attached to a substrate using two legs. The sensor operates at its bending resonance frequency and has cosine directional characteristics similar to that of a pressure gradient microphone. Thus, the directional response of the sensor is symmetric about the normal axis making the determination of the direction ambiguous. To overcome this shortcoming two sensors were assembled with a canted angle similar to that employed in radar bearing locators. The outputs of two sensors were processed together allowing direction finding with no requirement of knowing the incident sound pressure level. At the bending resonant frequency of the sensors (1.69 kHz) an output voltage of about 25 V/Pa was measured. The angle uncertainty of the bearing of sound ranged from less than 0.3° close to the normal axis (0°) to 3.4° at the limits of coverage (±60°) based on the 30° canted angle used. These findings indicate the great potential to use dual MEMS direction finding sensor assemblies to locate sound sources with high accuracy.
Capillary-induced Homogenization of Matrix in Paper: A Powerful Approach for the Quantification of Active Pharmaceutical Ingredients Using Mass Spectrometry Imaging
Authors: de Menezes Maico , de Oliveira Diogo Noin , Catharino Rodrigo Ramos 
Published: July 2016

AbstractHerein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously “eluted” with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry imaging (MSI) and quantification through characteristic fingerprints is ultimately performed. Results for the content of rosuvastatin from a known formulation are comparable to those obtained with a validated HPLC method.
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity
Authors: Lazzarini Edoardo , Balbi Carolina , Altieri Paola , Pfeffer Ulrich , Gambini Elisa , Canepa Marco , Varesio Luigi , Bosco Maria Carla , Coviello Domenico , Pompilio Giulio , Brunelli Claudio , Cancedda Ranieri , Ameri Pietro , Bollini Sveva 
Published: July 2016

AbstractThe anthracycline doxorubicin (Dox) is widely used in oncology, but it may cause a cardiomyopathy with bleak prognosis that cannot be effectively prevented. The secretome of human amniotic fluid-derived stem cells (hAFS) has previously been demonstrated to significantly reduce ischemic cardiac damage. Here it is shown that, following hypoxic preconditioning, hAFS conditioned medium (hAFS-CM) antagonizes senescence and apoptosis of cardiomyocytes and cardiac progenitor cells, two major features of Dox cardiotoxicity. Mechanistic studies with mouse neonatal ventricular cardiomyocytes (mNVCM) reveal that hAFS-CM inhibition of Dox-elicited senescence and apoptosis is associated with decreased DNA damage, nuclear translocation of NF-kB and upregulation of the NF-kB controlled genes,Il6andCxcl1, promoting mNVCM survival. Furthermore, hAFS-CM induces expression of the efflux transporter,Abcb1band Dox extrusion from mNVCM. The PI3K/Akt signaling cascade, upstream of NF-kB, is potently activated by hAFS-CM and pre-treatment with a PI3K inhibitor abrogates NF-kB accumulation into the nucleus, modulation ofIl6,Cxcl1andAbcb1band prevention of Dox-initiated senescence and apoptosis in response to hAFS-CM. These results support the concept that hAFS are a valuable source of cardioprotective factors and lay the foundations for the development of a stem cell-based paracrine treatment of chemotherapy-related cardiotoxicity.
Imaging of Osteoarthritic Human Articular Cartilage using Fourier Transform Infrared Microspectroscopy Combined with Multivariate and Univariate Analysis
Authors: Oinas J. , Rieppo L. , Finnilä M. A. J. , Valkealahti M. , Lehenkari P. , Saarakkala S. 
Published: July 2016

AbstractThe changes in chemical composition of human articular cartilage (AC) caused by osteoarthritis (OA) were investigated using Fourier transform infrared microspectroscopy (FTIR-MS). We demonstrate the sensitivity of FTIR-MS for monitoring compositional changes that occur with OA progression. Twenty-eight AC samples from tibial plateaus were imaged with FTIR-MS. Hyperspectral images of all samples were combined for K-means clustering. Partial least squares regression (PLSR) analysis was used to compare the spectra with the OARSI grade (histopathological grading of OA). Furthermore, the amide I and the carbohydrate regions were used to estimate collagen and proteoglycan contents, respectively. Spectral peak at 1338 cm−1 was used to estimate the integrity of the collagen network. The layered structure of AC was revealed using the carbohydrate region for clustering. Statistically significant correlation was observed between the OARSI grade and the collagen integrity in the superficial (r = −0.55) and the deep (r = −0.41) zones. Furthermore, PLSR models predicted the OARSI grade from the superficial (r = 0.94) and the deep (r = 0.77) regions of the AC with high accuracy. Obtained results suggest that quantitative and qualitative changes occur in the AC composition during OA progression and these can be monitored by the use of FTIR-MS.
A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons
Authors: Yan Lu , Hu Qinghua , Mak Marvin S. H. , Lou Jianshu , Xu Sherry L. , Bi Cathy W. C. , Zhu Yue , Wang Huaiyou , Dong Tina T. X. , Tsim Karl W. K. 
Published: July 2016

AbstractKai-Xin-San (KXS), a Chinese herbal decoction for anti-depression, is a combination of paired-herbs, i.e. Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR)-Poria (PO). The make-up of the paired-herbs has been commonly revised according to syndrome differentiation and treatment variation of individual. Currently, an optimized KXS (KXS2012) was prepared by functional screening different combination of GR-PR and ATR-PO. The aim of this study was to verify the effect and underlying mechanism of KXS2012 against depression in chronic mild stress (CMS)-induced depressive rats and in primary cultures of neurons and astrocytes. In rat model, the CMS-induced depressive symptoms were markedly alleviated by the treatment with KXS2012. The CMS-suppressed neurotransmitter amounts were restored in the presence of KXS2012. And the expressions of neurotropic factors and its corresponding receptors were increased under KXS2012 administration. In cultured neurons, application of KXS2012 could promote neurogenesis by inducing the expression of synaptotagmin and dendritic spine density. Moreover, application of KXS2012 in cultured astrocytes, or in H2O2-stressed astrocytes, induced the expressions of neurotrophic factors: the increase might be associated with the modification of Erk1/2 and CREB phosphorylation. Our current results fully support the therapeutic efficacy of KXS2012 against depression in cell and animal models.
Mitonuclear interactions, mtDNA-mediated thermal plasticity and implications for the Trojan Female Technique for pest control
Authors: Wolff Jonci N. , Tompkins Daniel M. , Gemmell Neil J. , Dowling Damian K. 
Published: July 2016

AbstractPest species pose major challenges to global economies, ecosystems and health. Unfortunately, most conventional approaches to pest control remain costly and temporary in effect. As such, a heritable variant of the Sterile Insect Technique (SIT) was proposed, based on the introduction of mitochondrial DNA mutations into pest populations, which impair male fertility but have no effects on females. Evidence for this “Trojan Female Technique” (TFT) was recently provided, in the form of a mutation in the mitochondrial cytochrome b gene (mt:Cyt-b) of Drosophila melanogaster which reduces male fertility across diverse nuclear backgrounds. However, recent studies have shown that the magnitude of mitochondrial genetic effects on the phenotype can vary greatly across environments, with mtDNA polymorphisms commonly entwined in genotype-by-environment (G × E) interactions. Here we test whether the male-sterilizing effects previously associated with the mt:Cyt-b mutation are consistent across three thermal and three nuclear genomic contexts. The effects of this mutation were indeed moderated by the nuclear background and thermal environment, but crucially the fertility of males carrying the mutation was invariably reduced relative to controls. This mutation thus constitutes a promising candidate for the further development of the TFT.
Efficacy of Statin Therapy in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis
Authors: Rysz-Górzynska Magdalena , Gluba-Brzózka Anna , Sahebkar Amirhossein , Serban Maria-Corina , Mikhailidis Dimitri P. , Ursoniu Sorin , Toth Peter P. , Bittner Vera , Watts Gerald F. , Lip Gregory Y. H. , Rysz Jacek , Catapano Alberico L. , Banach Maciej 
Published: July 2016

AbstractSince the evidence regarding statin therapy in PAH has not been conclusive, we assessed the impact of statin therapy in PAH through a systematic review and meta-analysis of available studies. We searched selected databases up to August 1, 2015 to identify the studies investigating the effect of statin administration on PAH. Meta-analysis was performed using either a fixed-effects or random-effect model according to I2 statistic. Meta-analysis of 8 studies with 665 patients did not suggest any significant improvement in 6-min walking distance (6MWD) by statin therapy (weighed mean difference [WMD]: −6.08 m, 95% confidence interval [CI]: −25.66, 13.50, p = 0.543; Q = 8.41, I2 = 28.64%). Likewise, none of the other indices including pulmonary arterial pressure (WMD: −0.97 mmHg, 95%CI: −4.39, 2.44, p = 0.577; Q = 14.64, I2 = 79.51%), right atrial pressure (WMD: 1.01 mmHg, 95%CI: −0.93, 2.96, p = 0.307; Q = 44.88, I2 = 95.54%), cardiac index (WMD: 0.05 L/min/m2, 95%CI: −0.05, 0.15, p = 0.323; Q = 3.82, I2 = 21.42%), and pulmonary vascular resistance (WMD: −1.42 dyn*s/cm5, 95%CI: −72.11, 69.27, p = 0.969; Q = 0.69, I2 = 0%) was significantly altered by statin therapy. In conclusion, the results of the meta-analysis did not show a statistically significant effect of statin therapy in the improvement of 6MWD, pulmonary arterial pressure, right atrial pressure, cardiac index and pulmonary vascular resistance.
Efficient embedding of complex networks to hyperbolic space via their Laplacian
Authors: Alanis-Lobato Gregorio , Mier Pablo , Andrade-Navarro Miguel A. 
Published: July 2016

AbstractThe different factors involved in the growth process of complex networks imprint valuable information in their observable topologies. How to exploit this information to accurately predict structural network changes is the subject of active research. A recent model of network growth sustains that the emergence of properties common to most complex systems is the result of certain trade-offs between node birth-time and similarity. This model has a geometric interpretation in hyperbolic space, where distances between nodes abstract this optimisation process. Current methods for network hyperbolic embedding search for node coordinates that maximise the likelihood that the network was produced by the afore-mentioned model. Here, a different strategy is followed in the form of the Laplacian-based Network Embedding, a simple yet accurate, efficient and data driven manifold learning approach, which allows for the quick geometric analysis of big networks. Comparisons against existing embedding and prediction techniques highlight its applicability to network evolution and link prediction.