bluuebunny/crossref_metadata_2025_split huggingface dataset:
Janus kinase 2 mutations in cases with BCR-ABL-negative chronic myeloproliferative disorders from Turkey
Authors: Yildiz Ismail , Yokuş Osman , Gedik Habip 
Published: January 2017

Abstract
Objective: We aimed to investigate the frequency of Janus kinase 2 ( JAK2) mutations in cases with chronic myeloproliferative disorders (CMDs), and the relationship between the presence of JAK2 mutation and leukocytosis and splenomegaly, retrospectively. Materials and Methods: Patients, who were diagnosed with BCR-ABL-negative CMDs according to diagnosis criteria of the World Health Organization and followed up at the hematology clinic between 2013 and 2015, were investigated in terms of the frequency of JAK2 mutation in cases with CMDs, and the relationship between the presence of JAK2 mutation and leukocytosis and splenomegaly, retrospectively. Results: In total, 100 patients, who were diagnosed with BCR-ABL-negative CMDs, were evaluated retrospectively. The mean age of the patients with JAK2 positivity was significantly higher compared to patients with negative. JAK2-positivity rates in the age groups were significantly different. Gender, diagnosis, splenomegaly, and leukocytosis were not statistically different for JAK2 positivity between the groups. Conclusion: JAK2 V617F mutation is more commonly seen in older age as a risk for complications related to CDMS. Splenomegaly and leukocytosis are not associated with JAK2 V617F mutation.
Pharmacogenomics of neuropathic pain
Authors: Sharma Vandana ,   Munish
Published: January 2017

AbstractVariation in pain sensitivity and analgesic drug response is well recognized among individuals. Pharmacogenomics hypothesis dictates that a patient’s response to a drug or development of adverse drug effects may depend on variation in genetic profile, in particular, the different alleles for the same gene that an individual carries. A review of the role of genetic variations in determining the receptor sensitivity and modulation of pain, response to analgesics drugs and their interactions are presented in this article. It is already known that genomic variations affect the pharmacokinetic and pharmacodynamic properties of various analgesic drugs. Genes related to the expression of mu-opioid receptor, ATP- binding cassette B1 (ABCB1), catechol-O-Methyl Transferase (COMT), Cytochrome P450 enzymes have been widely studied and show some promise in determining the drug response in individuals. Some recent studies on sodium channel mutations (SCN9A, SCN11A) have been implicated in congenital insensitivity to pain. Voltage gated ion channels such as sodium, calcium and potassium channels are being targeted for development of novel analgesics. Based on the available research, the clinical implementation of pharmacogenomics for personalized pain medicine is still in its infancy, but is promising. These are opening further opportunities for development of newer analgesics targeting pain receptors and ion channels.
Comparison of illness severity scoring systems for mortality prediction in Neurointensive Care Unit in India
Authors: Bansal Sonia , Surve Rohini , Muthuchellappan Radhakrishnan , Umamaheswara Rao Ganne , Philip Mariamma 
Published: January 2017

Abstract
Background: Illness severity scoring systems (SSs) are increasingly being used to provide information about patients’ severity of illness and outcome in terms of mortality or length of Intensive care Unit (ICU) and hospital stay. In this retrospective study, we compared the predictive power of Acute Physiology and Chronic Health Evaluation (APACHE) II and IV, Simplified Acute Physiology Score (SAPS), Mortality Prediction Model at 24 h and Glasgow Coma Scale (GCS) with actual in-hospital 28 day mortality in patients admitted to neuro-ICU over a period of 6 months. Methods: The data required for calculation of above scores was retrieved from medical records. The 28-day post-admission outcome including in-hospital mortality was measured by Glasgow Outcome Scale (GOS). Logistic regression was used to determine the mortality prediction power of each SS. Results: A total of 197 adult patients with varied neurological diagnosis were included in this study. The in-hospital 28-day mortality rate was 19.8%, and the scores of all the SSs correlated significantly with GOS (P < 0.001). All the scores were significantly different between survivors and non-survivors. The accuracy of all the SSs to predict survival and non-survival was more than 80%. The highest accuracy rate was seen for GCS and SAPS (84.3% and 83.8%, respectively). Conclusions: The SSs used in this study had good predictive power, and they had good discriminative ability between survivors and non-survivors. GCS and SAPS have the highest predictive ability, GCS having added advantage of being simple and practical.
Monitoring Structured Experiences during Youth Programs: Development of Brief Measures of Perceived Value and Engagement
Authors: Ellis Gary D. , Taggart Allen S. , Martz Jill , Lepley Toby , Jamal Tazim 
Published: January 2017

A brief questionnaire that can be used to routinely monitor the quality of structured experiences for youth is discussed in this paper. Structured experiences are discrete periods of time in which youth gather for activity under the supervision of adult or youth leaders. Four-item measures of perceived value and engagement were created. A questionnaire including these measures along with items from the 4-H Common Measures was administered to 219 youth from 11 4-H clubs. Data were analyzed for evidence of reliability and validity. Alpha reliability estimates were .82 and .71 for the two multiple-item monitoring instruments. Correlations (validity coefficients) ranged from .48 to .61. Multiple regression results were consistent with predictions. Significant relations were found between perceived value, engagement, meaningfulness and supportiveness of social climate and safety of social climate. Results thus suggest that these instruments may be appropriate for use in monitoring structured experiences for youth.
Domesticating Digital Game-based Learning
Authors: Sigurðardóttir Helga Dís Ísfold 
Published: January 2017

This paper analyses the use of digital game-based learning in schools in Norway. It investigates the types of games used in Norwegian schools and how pupils experience this practice. As a result of the increased focus on digital skills in Norwegian education digital game-based learning is widely employed throughout Norway. This paper analyses this usage by way of focus group interviews with a total of sixty-four pupils in four different schools. It draws upon domestication theory, actor-network theory, and the concept of script, and makes use of Latour's assemblage approach.Norwegian schools employ a variety of digital games for learning. Games used at the primary school level seem somewhat simpler in structure than those used a secondary school level. The domestication of digital game-based learning occurs through the construction of complex game-based learning assemblages. Games are applied in school and at home, as group work and as individual assignments, played on PCs and iPads. Pupils generally appreciate this practice, although they point out that digital games may have some shortcomings as teaching tools, and at the same time acknowledge a social stigma. Digital games play several different roles as non-human agents and, while educational games are played by the script, commercial games undergo certain script changes when employed in school settings. The domestication of digital game-based learning is a collective kind of domestication whereby both teachers and pupils engage in a two-way process.
Factor analysis of teacher professional development and evaluation based on math methods of RaschGSP curve, ISM, GSM and MSM
Authors: Ho Hui-Chung , Pham Duc-Hieu , Nguyen Phung-Tuyen , Fann Woody Jann-Der , Chiang Hsiu-Jye , Nagai Masatake 
Published: January 2017

Professionalism has been estimated as the most important fundamental impetus in progress. Teacher profession as the most important within-school factor has been emerged to explain effective teaching and learning by research. In viewing of teacher in-service training, professional development and innovation is thus highlighted as key prerequisite for high quality teaching. Factor analysis of teacher professional development and evaluation based on math methods was primarily to identify factorial sequences of activity involving two teamwork in the classroom. The purpose of this study is to perform to: 1) Couple quantitative and qualitative accesses to display teaching research; 2) Deliver the differences of pedagogical reasoning between graduate students and undergraduate students; 3) Analyze and visualize the educational practices based on math methods, the former is to embody educational performance in academic features, the latter is to communicate concretely and contextually. Researchtechniques herewith are Nagai’s proposals of Rasch model GSP curve (RaschGSP curve), Grey structural modeling (GSM) and Matrix-based structure modeling (MSM) have been applied to illustrate structural analysis.
Tensor Product Of Zero-divisor Graphs With Finite Free Semilattices
Authors: Toker Kemal 
Published: January 2017

$\Gamma (SL_{X})$ is defined and has been investigated in (Toker, 2016). In this paper our main aim is to extend this study over $\Gamma (SL_{X})$ to the tensor product. The diameter, radius, girth, domination number, independence number, clique number, chromatic number and chromatic index of $\Gamma (SL_{X_{1}})\otimes \Gamma (SL_{X_{2}})$ has been established. Moreover, we have determined when $\Gamma (SL_{X_{1}})\otimes \Gamma (SL_{X_{2}})$ is a perfect graph.
Het fzo-pandrecht op giraal saldo: een alternatief voor de huidige verpandingspraktijk
Authors: Swinkels S. 
Published: January 2017

Het fzo-pandrecht op giraal saldo: een alternatief voor de huidige verpandingspraktijk
Het pandrecht in het kader van een financiëlezekerheidsovereenkomst (fzo-pandrecht) is nog een vrij onbekende rechtsfiguur. Onterecht, want het fzo-pandrecht kan in de praktijk een andere uitwerking hebben dan ‘reguliere’ pandrechten en daarmee voordelen meebrengen voor marktpartijen. In dit artikel wordt onderzocht of fzo-pandrechten gebruikt kunnen worden in de huidige verpandingspraktijk, waar vooralsnog een openbaar pandrecht wordt bedongen op het girale saldo van een bankrekening. Belangrijk aspect van deze praktijk is dat de pandgever in zijn hoedanigheid van rekeninghouder over de rekening wil blijven beschikken. Dit levert problemen op met het zogenaamde ‘controlevereiste’.
Een notariële redactiefout in een uiterste wil
Authors: Breemhaar W. 
Published: January 2017

Een notariële redactiefout in een uiterste wil. Rb. Amsterdam 16 december 2015, ECLI:NL:RBAMS:2015:9032
De bijdrage behelst een kritische bespreking van het vonnis van de Rechtbank Amsterdam van 16 december 2015, ECLI:NL:RBAMS:2015:9032, omtrent een notariële redactiefout in een uiterste wil. Het praktische belang van het leerstuk van de discrepantie tussen wil en verklaring (art. 3:33 BW) in een dergelijk geval wordt in het bijzonder onderstreept.
Marine turtles are not fussy nesters: a novel test of small-scale nest site selection using structure from motion beach terrain information
Authors: Kelly Ilana , Leon Javier X. , Gilby Ben L. , Olds Andrew D. , Schlacher Thomas A. 
Published: January 2017

BackgroundNest selection is widely regarded as a key process determining the fitness of individuals and viability of animal populations. For marine turtles that nest on beaches, this is particularly pivotal as the nesting environment can significantly control reproductive success.The aim of this study was to identify the environmental attributes of beaches (i.e., morphology, vegetation, urbanisation) that may be associated with successful oviposition in green and loggerhead turtle nests.MethodsWe quantified the proximity of turtle nests (and surrounding beach locations) to urban areas, measured their exposure to artificial light, and used ultra-high resolution (cm-scale) digital surface models derived from Structure-from-Motion (SfM) algorithms, to characterise geomorphic and vegetation features of beaches on the Sunshine Coast, eastern Australia.ResultsAt small spatial scales (i.e., <100 m), we found no evidence that turtles selected nest sites based on a particular suite of environmental attributes (i.e., the attributes of nest sites were not consistently different from those of surrounding beach locations). Nest sites were, however, typically characterised by occurring close to vegetation, on parts of the shore where the beach- and dune-face was concave and not highly rugged, and in areas with moderate exposure to artificial light.ConclusionThis study used a novel empirical approach to identify the attributes of turtle nest sites from a broader ‘envelope’ of environmental nest traits, and is the first step towards optimizing conservation actions to mitigate, at the local scale, present and emerging human impacts on turtle nesting beaches.
Mineralogical, geochemical, and magnetic signatures of surface sediments from the Canadian Beaufort Shelf and Amundsen Gulf (Canadian Arctic)
Authors: Gamboa Adriana , Montero‐Serrano Jean‐Carlos , St‐Onge Guillaume , Rochon André , Desiage Pierre‐Arnaud 
Published: January 2017

AbstractMineralogical, geochemical, magnetic, and siliciclastic grain‐size signatures of 34 surface sediment samples from the Mackenzie‐Beaufort Sea Slope and Amundsen Gulf were studied in order to better constrain the redox status, detrital particle provenance, and sediment dynamics in the western Canadian Arctic. Redox‐sensitive elements (Mn, Fe, V, Cr, Zn) indicate that modern sedimentary deposition within the Mackenzie‐Beaufort Sea Slope and Amundsen Gulf took place under oxic bottom‐water conditions, with more turbulent mixing conditions and thus a well‐oxygenated water column prevailing within the Amundsen Gulf. The analytical data obtained, combined with multivariate statistical (notably, principal component and fuzzy c‐means clustering analyses) and spatial analyses, allowed the division of the study area into four provinces with distinct sedimentary compositions: (1) the Mackenzie Trough‐Canadian Beaufort Shelf with high phyllosilicate‐Fe oxide‐magnetite and Al‐K‐Ti‐Fe‐Cr‐V‐Zn‐P contents; (2) Southwestern Banks Island, characterized by high dolomite‐K‐feldspar and Ca‐Mg‐LOI contents; (3) the Central Amundsen Gulf, a transitional zone typified by intermediate phyllosilicate‐magnetite‐K‐feldspar‐dolomite and Al‐K‐Ti‐Fe‐Mn‐V‐Zn‐Sr‐Ca‐Mg‐LOI contents; and (4) mud volcanoes on the Canadian Beaufort Shelf distinguished by poorly sorted coarse‐silt with high quartz‐plagioclase‐authigenic carbonate and Si‐Zr contents, as well as high magnetic susceptibility. Our results also confirm that the present‐day sedimentary dynamics on the Canadian Beaufort Shelf is mainly controlled by sediment supply from the Mackenzie River. Overall, these insights provide a basis for future studies using mineralogical, geochemical, and magnetic signatures of Canadian Arctic sediments in order to reconstruct past variations in sediment inputs and transport pathways related to late Quaternary climate and oceanographic changes.
Midcrustal shearing and doming in aCenozoic compressive setting along theAilaoShan‐RedRiver shear zone
Authors: Zhang B. , Yin C. Y. , Zhang J. J. , Wang J. M. , Zhong D. L. , Wang Y. , Lai Q. Z. , Yue Y. H. , Zhou Q. Y. 
Published: January 2017

AbstractThe Cenozoic Xuelong Shan antiformal dome is located along the northern segment of the Ailao Shan‐Red River shear zone in Yunnan, China. Subhorizontal foliation in the gneiss core is recognized, representing a broad top‐to‐NE shear initiated under amphibolite facies conditions and propagating into greenschist facies in the mantling schist and strike‐slip shear zone. Microfabrics of crystallographic‐preferred orientations (CPOs) in quartz suggest that the deformation temperatures increased with increasing structural depth from the upper crust (300–500°C) in the mantling schist to the midcrust (15 km or more, ≥650°C) in the gneissic core. This trend is mirrored by variations in the metamorphic grade of the syn‐kinematic mineral assemblages and microstructures, which range from garnet + amphibole + biotite + sillimanite + rutile + feldspar in the core to garnet + staurolite + biotite + epidote + muscovite within the limb units. The dome experienced the following deformation history: (1) a broad top‐to‐NE shear in the subhorizontal foliation of the gneiss core during the first stage of deformation (D1); (2) opposing reverse‐sense shear along the two schist limbs of the dome during contraction‐related doming (D2–D3); (3) sinistral strike‐slip shearing within the eastern limb (D4); and (4) extensional deformation (D5). The structural‐thermal patterns suggest the antiformal dome formation was roughly coeval with top‐to‐NE ductile shearing in the midcrust of Tibet at 32 Ma or earlier. A major implication is that there was a phase of contractional ductile deformation in the region prior to the initiation of strike‐slip deformation.
Metamorphic records for subduction erosion and subsequent underplating processes revealed by garnet‐staurolite‐muscovite schists in central Qiangtang, Tibet
Authors: Zhang Xiu‐Zheng , Dong Yong‐Sheng , Wang Qiang , Dan Wei , Zhang Chunfu , Xu Wang , Huang Ming‐Liang 
Published: January 2017

AbstractSubduction erosion is confirmed as a crucial geodynamic process of crustal recycling based on geological, geochemical, and geophysical observations at modern convergent plate margins. So far, not a single metamorphic record has been used for constraining a general tectonic evolution for subduction erosion. Here we first revealed metamorphic records for a subduction erosion process based on our study of the Late Paleozoic garnet‐staurolite‐muscovite schists in the central Qiangtang block, Tibet. Provenance analyses suggest that the protoliths of garnet‐staurolite‐muscovite schists have the Northern Qiangtang‐affinity and were deposited in an active continental margin setting. Mineral inclusion data show that the early metamorphic stage (M1) recorded blueschist facies pressure‐temperature (P‐T) conditions of 0.8–1.1 GPa and 402–441°C, indicating that a part of the material from the overriding plate had been abraded into the subduction channel and undergone high‐pressure/low‐temperature metamorphism. The peak metamorphic stage (M2) recorded amphibolite facies P‐T conditions of 0.3–0.5 GPa and 470–520°C. The 40Ar/39Ar cooling ages (263–259 Ma) yielded from muscovite suggest the amphibolite facies metamorphism (>263 Ma) occurred at oceanic subduction stage. The distinctly staged metamorphism defines a clockwise and warming decompression P‐T‐t path which reveals an underplating process following the early subduction erosion. During the tectonic process, the eroded low‐density material escaped from the cold subduction channel and rise upward into the warm middle‐lower crust of the upper plate, undergoing amphibolite facies metamorphism. Our new results revealed a complete evolutional process from the early subduction erosion to the subsequent underplating during the northward subduction of the Paleo‐Tethys Ocean.
Influence of mantle flow on the drainage of eastern Australia since the Jurassic Period
Authors: Salles T. , Flament N. , Müller D. 
Published: January 2017

AbstractRecent studies of the past eastern Australian landscape from present‐day longitudinal river profiles and from mantle flow models suggest that the interaction of plate motion with mantle convection accounts for the two phases of large‐scale uplift of the region since 120 Ma. We coupled the dynamic topography predicted from one of these mantle flow models to a surface process model to study the evolution of the eastern Australian landscape since the Jurassic Period. We varied the rainfall regime, erodibility, sea level variations, dynamic topography magnitude, and elastic thickness across a series of experiments. The approach accounts for erosion and sedimentation and simulates catchment dynamics. Despite the relative simplicity of our model, the results provide insights on the fundamental links between dynamic topography and continental‐scale drainage evolution. Based on temporal and spatial changes in longitudinal river profiles as well as erosion and deposition maps, we show that the motion of the Australian plate over the convecting mantle has resulted in significant reorganization of the eastern Australian drainage. The model predicts that the Murray river drained eastward between 150 and ∼120 Ma, and switched to westward draining due to the tilting of the Australian plate from ∼120 Ma. First order comparisons of eight modeled river profiles and of the catchment shape of modeled Murray‐Darling Basin are in agreement with present‐day observations. The predicted denudation of the eastern highlands is compatible with thermochronology data and sedimentation rates along the southern Australian margin are consistent with cumulative sediment thickness.
Fidelity of the Sr/Ca proxy in recording ocean temperature in the western Atlantic coral Siderastrea siderea
Authors: Kuffner Ilsa B. , Roberts Kelsey E. , Flannery Jennifer A. , Morrison Jennifer M. , Richey Julie N. 
Published: January 2017

AbstractMassive corals provide a useful archive of environmental variability, but careful testing of geochemical proxies in corals is necessary to validate the relationship between each proxy and environmental parameter throughout the full range of conditions experienced by the recording organisms. Here we use samples from a coral‐growth study to test the hypothesis that Sr/Ca in the coral Siderastrea siderea accurately records sea‐surface temperature (SST) in the subtropics (Florida, USA) along 350 km of reef tract. We test calcification rate, measured via buoyant weight, and linear extension (LE) rate, estimated with Alizarin Red‐S staining, as predictors of variance in the Sr/Ca records of 39 individual S. siderea corals grown at four outer‐reef locations next to in‐situ temperature loggers during two, year‐long periods. We found that corals with calcification rates < 1.7 mg cm−2 d−1 or < 1.7 mm yr−1 LE returned spuriously high Sr/Ca values, leading to a cold‐bias in Sr/Ca‐based SST estimates. The threshold‐type response curves suggest that extension rate can be used as a quality‐control indicator during sample and drill‐path selection when using long cores for SST paleoreconstruction. For our corals that passed this quality control step, the Sr/Ca‐SST proxy performed well in estimating mean annual temperature across three sites spanning 350 km of the Florida reef tract. However, there was some evidence that extreme temperature stress in 2010 (cold snap) and 2011 (SST above coral‐bleaching threshold) may have caused the corals not to record the temperature extremes. Known stress events could be avoided during modern calibrations of paleoproxies.