bluuebunny/crossref_metadata_2025_split huggingface dataset:
SerpinB3 Promotes Pro-fibrogenic Responses in Activated Hepatic Stellate Cells
Authors: Novo Erica , Villano Gianmarco , Turato Cristian , Cannito Stefania , Paternostro Claudia , Busletta Chiara , Biasiolo Alessandra , Quarta Santina , Morello Elisabetta , Bocca Claudia , Miglietta Antonella , David Ezio , Sutti Salvatore , Plebani Mario , Albano Emanuele , Parola Maurizio , Pontisso Patrizia 
Published: June 2017

AbstractSerpinB3 is a hypoxia- and hypoxia-inducible factor-2α-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been reported to correlate with the extent of liver fibrosis and the production of transforming growth factor-β1, but the actual role of SerpinB3 in hepatic fibrogenesis is still poorly characterized. In the present study we analyzed the pro-fibrogenic action of SerpinB3 in cell cultures and in two different murine models of liver fibrosis. “In vitro” experiments revealed that SerpinB3 addition to either primary cultures of human activated myofibroblast-like hepatic stellate cells (HSC/MFs) or human stellate cell line (LX2 cells) strongly up-regulated the expression of genes involved in fibrogenesis and promoted oriented migration, but not cell proliferation. Chronic liver injury by CCl4 administration or by feeding a methionine/choline deficient diet to transgenic mice over-expressing human SerpinB3 in hepatocytes confirmed that SerpinB3 over-expression significantly increased the mRNA levels of pro-fibrogenic genes, collagen deposition and αSMA-positive HSC/MFs as compared to wild-type mice, without affecting parenchymal damage. The present study provides for the first time evidence that hepatocyte release of SerpinB3 during CLD can contribute to liver fibrogenesis by acting on HSC/MFs.
Bi‐directional SIW leaky‐wave antenna using TE20 mode for frequency beam scanning
Authors: Sarkar A. , Sharma A. , Adhikary M. , Biswas A. , Akhtar M.J. 
Published: June 2017

A compact bi‐directional leaky‐wave antenna (LWA) based on TE20 mode substrate integrated waveguide (SIW) is proposed at X‐band. The microstrip power divider–slotline transitions are utilised to excite TE20 mode SIW array in order to enhance the overall radiation capability of the designed structure. The rectangular slots are etched out on the top and bottom plane of SIW such a way that the orientation of the slots can perturb the distribution of electric field at TE20 mode and provide bi‐directional radiation. The proposed antenna is working within the frequency range of 9.6–11.2 GHz (S11 < −10 dB) having the beam scanning range of 66° from both top and bottom side of the structure with maximum gain of 14 dBi. All experimental results show a fair agreement with the simulated data.
Management of the Third Stage of Labor: How Delayed Umbilical Cord Clamping Can Affect Neonatal Outcome
Authors: Kresch Mitchell 
Published: June 2017

AbstractThis review presents the effects of delayed umbilical cord clamping on neonatal transitional physiology. The effects of delayed cord clamping on short- and long-term neonatal outcomes are then discussed. There is ample evidence over the last 50 years that delayed cord clamping in preterm infants is beneficial for both short-term and long-term outcomes. Providing ventilation in the initial steps of neonatal resuscitation prior to clamping of the umbilical cord has a physiologic basis and results in better outcomes for newborns. The challenge now is to design equipment and strategies that can allow initial resuscitation very close to the mother while the umbilical cord is still attached to the placenta.
„Morbus Google“ vs. e-Health: Qualitative Untersuchung zur Akzeptanz und Implementierung von Online-Nachsorge in der stationären Rehabilitation
Authors: Hennemann Severin , Beutel Manfred , Zwerenz Rüdiger 
Published: June 2017

Zusammenfassung
Hintergrund Internet- und mobilbasierte Gesundheitsinterventionen (IMIs) können z. B. in Form von Nachsorgeangeboten das Behandlungsangebot der Rehabilitation erweitern. Für die Implementierung ist jedoch deren Akzeptanz eine wesentliche Voraussetzung, die daher bei Rehabilitanden und Mitarbeitern qualitativ untersucht wurde.
Methodik In 3 Rehabilitationskliniken mit verschiedenen Indikationen und Altersgruppen wurden n=15 Rehabilitanden in Einzelinterviews und n=29 Mitarbeiter verschiedener Berufsgruppen in Fokusgruppen nach einem semi-strukturierten Leitfaden auf Basis der “Unified Theory of Acceptance and Use of Technology“ interviewt.
Ergebnisse Vorteile einer Online-Nachsorge wurden in den Möglichkeiten zur Aufbereitung von Informationen, Motivation, Verlaufsbeobachtung und Korrektur von Gesundheitsverhalten gesehen, weniger als ein Anwendungsbereich bei beruflichen Problemlagen. Vorbehalte zeigten sich v. a. bezüglich der therapeutischen Beziehung. Tendenziell war die Akzeptanz bei Rehabilitanden höher als bei Mitarbeitern.
Schlussfolgerung Die gefundenen Barrieren der Inanspruchnahme bzw. Anwendung von IMIs gehen über technische und demografische Aspekte hinaus. Sie sind wichtige Informationen für die gezielte Förderung der Akzeptanz sowohl bei Rehabilitanden wie auch bei Mitarbeitern.
Die Schweiß- und Duftdrüsen
Authors: Corts Magga 
Published: June 2017

SummaryDie Schweißdrüsen (Glandulae sudoriferae eccrinae) befinden sich zwischen Oberhaut (Epidermis) und Unterhaut (Subkutis), also in der Lederhaut (Dermis / Korium). Die Schweißdrüse hat einen Durchmesser von ca. 0,4 mm und ist knäuelartig gewunden. Sie ist für die Schweißsekretion verantwortlich. Die Duftdrüsen stellen einer Sonderform dar.
Accuracy of High-Field Intraoperative MRI in the Detectability of Residual Tumor in Glioma Grade IV Resections
Authors: Heßelmann Volker , Mager Ann-Kathrin , Goetz Claudia , Detsch Oliver , Theisgen Hannah-Katharina , Friese Michael , Schwindt Wolfram , Gottschalk Joachim , Kremer Paul 
Published: June 2017

Objective To assess the sensitivity/specificity of tumor detection by T1 contrast enhancement in intraoperative MRI (ioMRI) in comparison to histopathological assessment as the gold standard in patients receiving surgical resection of grade IV glioblastoma.
Materials and Methods 68 patients with a primary or a recurrent glioblastoma scheduled for surgery including fluorescence guidance and neuronavigation were included (mean age: 59 years, 26 female, 42 male patients). The ioMRI after the first resection included transverse FLAIR, DWI, T2-FFE and T1 – 3 d FFE +/- GD-DPTA. The second resection was performed whenever residual contrast-enhancing tissue was detected on ioMRI. Resected tissue samples were histopathologically evaluated (gold standard). Additionally, we evaluated the early postoperative MRI scan acquired within 48 h post-OP for remaining enhancing tissue and compared them with the ioMRI scan.
Results In 43 patients ioMRI indicated residual tumorous tissue, which could be confirmed in the histological specimens of the second resection. In 16 (4 with recurrent, 12 with primary glioblastoma) cases, ioMRI revealed truly negative results without residual tumor and follow-up MRI confirmed complete resection. In 7 cases (3 with recurrent, 4 with primary glioblastoma) ioMRI revealed a suspicious result without tumorous tissue in the histopathological workup. In 2 (1 for each group) patients, residual tumorous tissue was detected in spite of negative ioMRI. IoMRI had a sensitivity of 95 % (94 % recurrent and 96 % for primary glioblastoma) and a specificity of 69.5 % (57 % and 75 %, respectively). The positive predictive value was 86 % (84 % for recurrent and 87 % for primary glioblastoma), and the negative predictive value was 88 % (80 % and 92 %, respectively).
Conclusion ioMRI is effective for detecting remaining tumorous tissue after glioma resection. However, scars and leakage of contrast agent can be misleading and limit specificity.
Key points
Citation Format
Keine reine Hautsache!
Authors: Sylvester Corinna 
Published: June 2017

SummaryNeben Psoriasis machen Frau F. Schlafstörungen, Kopfschmerzen, Hypertonie sowie rezidivierende Blasenentzündungen und Thrombophlebitiden zu schaffen. Bei der EAV-Messung weisen viele Meridiane zu wenig Energie und Blockaden auf. Der Bioresonanztest deckt verschiedenste Pathogene auf. Die Behandlung zielt schwerpunktmäßig darauf ab, die Regulationsfähigkeit des Organismus wiederherzustellen und Pathogene auszuleiten.
Richtig abrechnen
Authors: Bosch Susanne 
Published: June 2017

SummaryDamit Klienten eine Chance auf Kostenerstattung haben, sollten sie sich zu Beginn der Behandlung umfassend bei ihrer Versicherungsgesellschaft informieren. Muss die Behandlung zunächst bewilligt werden, muss der Klient die benötigten Unterlagen beim behandelnden Arzt oder seiner Versicherung einholen. Erstattungsfähige Rechnungen müssen nach GebüH gestellt werden. Dabei ist es wichtig, zu wissen, welche Abrechnungsziffern kombinierbar sind und welche nicht.
Heißes Eisen
Authors: Lück-Knobloch Heike 
Published: June 2017

SummaryKein Nährstoff fehlt dem Menschen häufiger als Eisen, doch bis heute wird eine Eisenmangelanämie häufig übersehen. Meist sind Blutungen oder Mangelernährung verantwortlich, aber auch Darmentzündungen und Verwertungsstörungen müssen abgeklärt werden. Vier Schritte führen in der Regel zum Therapieerfolg: Diagnose, Beseitigung der Ursache, Eisensupplementierung und Ernährungsumstellung.
Weniger vorauszahlen, mehr sparen
Authors: Dornbusch Hans-Ludwig 
Published: June 2017

SummarySelbstständige Heilpraktiker müssen nach § 37 Einkommensteuergesetz (EStG) vierteljährlich Einkommensteuer-Vorauszahlungen leisten. Eine Einzugsermächtigung an das Finanzamt ist oft nicht sinnvoll. Bei Begleichung über Geldanlagen oder Kredite sollten Sie den letztmöglichen Zahlungstermin wählen. Eine Kürzung der Einkommensteuer-Vorauszahlungen können Sie beantragen, wenn Sie aufgrund geringerer Einnahmen oder höherer Ausgaben weniger Gewinn erwirtschaften.
Ecosystem-based management and the wealth of ecosystems
Authors: Yun Seong Do , Hutniczak Barbara , Abbott Joshua K. , Fenichel Eli P. 
Published: June 2017

Significance
Ecosystems store vast quantities of wealth, but difficulties measuring wealth held in ecosystems prevent its inclusion in accounting systems. Ecosystem-based management endeavors to manage ecosystems holistically. However, ecosystem-based management lacks headline indicators to evaluate performance. We unify the inclusive wealth and ecosystem-based management paradigms, allowing apples-to-apples comparisons between the wealth of the ecosystem and other forms of wealth, while providing a headline performance index for evaluating the performance of ecosystem-based management. We project that the Baltic Sea fishery ecosystem yields increasing stores of wealth over the next 50 y under the ecosystem-based management-inspired multispecies maximum sustainable yield management beginning in 2017, whereas the previous single-species management generally results in declining wealth.
Manipulating the ABCs of self-assembly via low-χ block polymer design
Authors: Chang Alice B. , Bates Christopher M. , Lee Byeongdu , Garland Carol M. , Jones Simon C. , Spencer Russell K. W. , Matsen Mark W. , Grubbs Robert H. 
Published: June 2017

Significance
Molecular sequence and interactions dictate the mesoscale structure of all self-assembling soft materials. Block polymers harness this relationship to access a rich variety of nanostructured materials but typically require energetically unfavorable (high-χ) interactions between blocks. Contrary to this convention, we demonstrate that ABC triblock terpolymers featuring low-χ interactions between end blocks can self-assemble into a unique mixed morphology that subverts the demands of chain connectivity. As a consequence of block–block mixing, the characteristic length scales of these self-assembled structures exhibit an unusual trend: As the total polymer size increases, the domain spacing decreases. These developments expand the vocabulary of block polymer design and open additional avenues for manipulating the self-assembly of synthetic macromolecules.
EpiCompare: an online tool to define and explore genomic regions with tissue or cell type-specific epigenomic features
Authors: He Yu , Wang Ting 
Published: June 2017

Abstract

Motivation
The Human Reference Epigenome Map, generated by the Roadmap Epigenomics Consortium, contains thousands of genome-wide epigenomic datasets that describe epigenomes of a variety of different human tissue and cell types. This map has allowed investigators to obtain a much deeper and more comprehensive view of our regulatory genome, e.g. defining regulatory elements including all promoters and enhancers for a given tissue or cell type. An outstanding task is to combine and compare different epigenomes in order to identify regions with epigenomic features specific to certain types of tissues or cells, e.g. lineage-specific regulatory elements. Currently available tools do not directly address this question. This need motivated us to develop a tool that allows investigators to easily identify regions with epigenetic features unique to specific epigenomes that they choose, making detection of common regulatory elements and/or cell type-specific regulatory elements an interactive and dynamic experience.

Results
An online tool EpiCompare was developed to assist investigators in exploring the specificity of epigenomic features across selected tissue and cell types. Investigators can design their test by choosing different combinations of epigenomes, and choosing different classification algorithms provided by our tool. EpiCompare will then identify regions with specified epigenomic features, and provide a quality assessment of the predictions. Investigators can interact with EpiCompare by investigating Roadmap Epigenomics data, or uploading their own data for comparison. We demonstrate that by using specific combinations of epigenomes we can detect developmental lineage-specific enhancers. Finally, prediction results can be readily visualized and further explored in the WashU Epigenome Browser.

Availability and implementation
EpiCompare is freely available on the web at http://epigenome.wustl.edu/EpiCompare/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Sparse redundancy analysis of high-dimensional genetic and genomic data
Authors: Csala Attila , Voorbraak Frans P J M , Zwinderman Aeilko H , Hof Michel H 
Published: June 2017

Abstract

Motivation
Recent technological developments have enabled the possibility of genetic and genomic integrated data analysis approaches, where multiple omics datasets from various biological levels are combined and used to describe (disease) phenotypic variations. The main goal is to explain and ultimately predict phenotypic variations by understanding their genetic basis and the interaction of the associated genetic factors. Therefore, understanding the underlying genetic mechanisms of phenotypic variations is an ever increasing research interest in biomedical sciences. In many situations, we have a set of variables that can be considered to be the outcome variables and a set that can be considered to be explanatory variables. Redundancy analysis (RDA) is an analytic method to deal with this type of directionality. Unfortunately, current implementations of RDA cannot deal optimally with the high dimensionality of omics data (p≫n). The existing theoretical framework, based on Ridge penalization, is suboptimal, since it includes all variables in the analysis. As a solution, we propose to use Elastic Net penalization in an iterative RDA framework to obtain a sparse solution.

Results
We proposed sparse redundancy analysis (sRDA) for high dimensional omics data analysis. We conducted simulation studies with our software implementation of sRDA to assess the reliability of sRDA. Both the analysis of simulated data, and the analysis of 485 512 methylation markers and 18,424 gene-expression values measured in a set of 55 patients with Marfan syndrome show that sRDA is able to deal with the usual high dimensionality of omics data.

Availability and implementation
http://uva.csala.me/rda.

Supplementary information
Supplementary data are available at Bioinformatics online.
Risk Factors for Readmission with Cerebrospinal Fluid Leakage Within 30 Days of Vestibular Schwannoma Surgery
Authors: Alattar Ali A , Hirshman Brian R , McCutcheon Brandon A , Chen Clark C , Alexander Thomas , Harris Jeffrey , Carter Bob S 
Published: June 2017

AbstractBACKGROUNDCerebrospinal fluid (CSF) leak is a well-recognized complication after surgical resection of vestibular schwannomas and is associated with a number of secondary complications, including readmission and meningitis.OBJECTIVETo identify risk factors for and timing of 30-d readmission with CSF leak.METHODSPatients who had undergone surgical resection of a vestibular schwannoma from 1995 to 2010 were identified in the California Office of Statewide Health Planning and Development database. The most common admission diagnoses were identified by International Classification of Disease, ninth Revision, diagnosis codes, and predictors of readmission with CSF leak were determined using logistic regression.RESULTSA total of 6820 patients were identified. CSF leak, though a relatively uncommon cause of admission after discharge (3.52% of all patients), was implicated in nearly half of 490 readmissions (48.98%). Significant independent predictors of readmission with CSF leak were male sex (odds ratio [OR] 1.72, 95% confidence interval [CI] 1.32-2.25), first admission at a teaching hospital (OR 3.32, 95% CI 1.06-10.39), CSF leak during first admission (OR 1.84, 95% CI 1.33-2.55), obesity during first admission (OR 2.10, 95% CI 1.20-3.66), and case volume of first admission hospital (OR of log case volume 0.82, 95% CI 0.70-0.95). Median time to readmission was 6 d from hospital discharge.CONCLUSIONThis study has quantified CSF leak as an important contributor to nearly half of all readmissions following vestibular schwannoma surgery. We propose that surgeons should focus on technical factors that may reduce CSF leakage and take advantage of potential screening strategies for the detection of CSF leakage prior to first admission discharge.
Novel imaging techniques in gynaecological cancer
Authors: Vandecaveye Vincent , Dresen Raphaëla , De Keyzer Frederik 
Published: June 2017

Purpose of review
To describe the added value of novel functional MRI techniques towards detection, staging, characterization, response monitoring and prognostication in gynaecological cancer.

Recent findings
Functional MRI including diffusion-weighted imaging (DWI)-MRI and dynamic contrast-enhanced (DCE)-MRI adds structural, hemodynamic and physiological information to anatomical MRI. In endometrial and cervical cancer, the addition of DWI-MRI and DCE-MRI improves tumour detection as well as staging of uterine and extra-uterine pelvic spread. Quantitative assessment of DWI and DCE-MRI reflecting tissue properties of biological aggressiveness or treatment resistance may enable the prediction of risk of extra-uterine or extra-ovarian disease spread, predict risk of recurrence and assess treatment response. DWI shows high accuracy for detecting peritoneal metastases and allows for comprehensive staging of (recurrent) ovarian cancer following the clinical development of whole body DWI-MRI.

Summary
The added value of DWI/DCE-MRI for characterization and staging of gynaecological malignancy is becoming increasingly established and may improve treatment stratification. Ongoing multicentre studies are expected to further consolidate its use in clinical routine. Quantitative evaluation of functional MRI may help in prognostication and risk stratification.
Determinants and Timeline of Perioperative Anxiety in Mohs Surgery
Authors: Kossintseva Irèn , Zloty David 
Published: June 2017

BACKGROUNDPatients undergoing Mohs micrographic surgery (MMS) exhibit anxiety relating to cancer cure or the expected cosmetic outcome.OBJECTIVETo obtain quantitative measurements of perioperative cancer and cosmetic anxiety levels in first-time MMS patients. Parameters influencing anxiety and its natural course were assessed.METHODSProspective, single-blinded, questionnaire study of 173 patients undergoing MMS of the face. Anxiety levels were assessed using a visual analog scale preoperatively and postoperatively over 6 months.RESULTSMohs patients demonstrate a trend to greater or equal anxiety about cancer over cosmesis at all measured time points, but differences only reached statistical significance beginning 1 week postoperatively. Clinically relevant lowering of cancer anxiety levels is delayed until 3 months postoperatively. Cosmetic anxiety reaches a clinically relevant improvement by 1 week. The intuitive predictors of cosmetic anxiety, namely female gender and younger age, were quantitatively reinforced in this study. The predictor of cancer anxiety was the use of preoperative lorazepam.CONCLUSIONTo maximize patient care, Mohs surgeons must be aware of covert patient anxieties and the parameters, which influence these anxieties. Identifying and anticipating the course of cancer- and cosmetic-related anxieties will reduce patient fears, improving their satisfaction with the MMS experience.
Use of Turn-in Skin Flaps for Nasal Lining Reconstruction
Authors: Yazar Memet , Yazar Sevgi Kurt , Kozanoğlu Erol , Diyarbakırlıoğlu Murat , Eren Hikmet İhsan 
Published: June 2017

BACKGROUND
Reconstruction of the nasal lining is the most difficult part of complex nasal reconstruction because the mucosa has a unique texture and fineness. Many techniques, ranging from skin grafts to local flaps, have been applied for the reconstruction of the mucosa. In some cases, even free flaps have been used.

OBJECTIVE
The aim of this study was to discuss the feasibility of using turn-in flaps in nasal reconstruction.

MATERIALS AND METHODS
Seventeen patients with full-thickness nasal defects underwent reconstruction with turn-in flaps. In all the patients, the bone structure was formed using cartilage grafts, and the skin defects were reconstructed using paramedian forehead flaps. A rhinoplasty procedure was added in 10 of the patients.

RESULTS
Necrosis was not observed in any of the flaps, and the results were satisfactory for all the patients.

CONCLUSION
This technique provided enough support for the onlay cartilage grafts, and the flap was thin enough to avoid any nasal airway obstruction. In selected patients, this technique can also be used in conjunction with a rhinoplasty procedure.