bluuebunny/crossref_metadata_2025_split huggingface dataset:
WTAP‐mediated m6A modification of circ_0032463 promotes osteosarcoma progression by sponging miR‐145‐5p and regulating GFRA1 expression
Authors: Huang Zhong , Chen Pengcheng , Liu Yiheng 
Published: September 2024

AbstractOsteosarcoma (OS) is the most frequent bone malignancy in humans. Previous evidence suggest that circ_0032463 is an oncogenic circular RNA (circRNA) in various cancers, including OS. However, the molecular mechanism of circ_0032463 involved in OS is still unclear. Circ_0032463, microRNA‐145‐5p (miR‐145‐5p), GDNF receptor alpha 1 (GFRA1), and Wilms tumor 1‐associated protein (WTAP) levels were determined using real‐time quantitative polymerase chain reaction (RT‐qPCR). Cell proliferation, apoptosis, migration, invasion, and angiogenesis were analyzed using 5‐ethynyl‐2′‐deoxyuridine (EdU), flow cytometry, transwell, and tube formation assays. Western blot analysis was performed to measure matrix metalloproteinase 2 (MMP2), MMP9, GFRA1, and WTAP protein levels. Binding between miR‐145‐5p and circ_0032463 or GFRA1 was confirmed using a dual‐luciferase reporter and pull‐down assay. The biological role of circ_0032463 on OS cell growth was also analyzed using a xenograft tumor model in vivo. Methylated RNA immunoprecipitation assay validated the interaction between WTAP and circ_0032463. Circ_0032463, GFRA1, and WTAP levels were increased, and miR‐145‐5p was decreased in OS tissues and cells. Circ_0032463 deficiency might hinder OS cell proliferation, migration, invasion, angiogenesis, and promote apoptosis in vitro. Mechanically, circ_0032463 worked as a miR‐145‐5p sponge to increase GFRA1 expression. Repression of circ_0032463 knockdown on tumor cell growth was proved in vivo. Besides, N6‐methyladenosine (m6A) modification facilitates the biogenesis of circ_0032463. Taken together, m6A‐mediated biogenesis of circ_0032463 facilitates OS cell malignant biological behavior partly via regulating the miR‐145‐5p/GFRA1 axis, suggesting a promising molecular marker for OS treatment.
Enterprise environmental performance under China's framework for Central Environmental Protection Inspection: Quasi‐natural experimental evidence
Authors: Li Xiang , Lan Hailin , Zeng Ping 
Published: September 2024

AbstractIn 2016, China launched the Central Environmental Protection Inspection (CEPI) to address environmental pollution. Using a triple‐difference method with data from China's A‐share listed companies between 2010 and 2019, we find that CEPI significantly improves the environmental performance of firms. The improvements are driven by increased environmental awareness, stricter enforcement and greater investment in environmental protection. Fiscal and environmental decentralization positively reinforce the policy's effectiveness. Regions with high public participation, media attention, and visibility experience greater benefits. This research highlights the importance of combining policy initiatives with active public and media engagement to achieve significant environmental improvements.
Elevation‐dependent warming and possible‐driving mechanisms over global highlands
Authors: Abbas Haider , Daramola Mojolaoluwa Toluwalase , Xu Ming 
Published: September 2024

AbstractElevation‐dependent warming (EDW) has been a topic of intense debate due to limited observed data in global highland areas. This study aims to fill this gap by utilizing CRU and ERA5 datasets from 1981 to 2021 to explore the trends of climate change and its elevation dependency. The anomalies of temperature indicators (Tmean, Tmax, and Tmin) in both ERA5 and CRU showed significant warming trends over global highlands. Moreover, the response of temperature indicators to elevation across global highlands is not spatially uniform. The linear regression model based on the elevation showed significant warming signals for the temperature indicators at various elevations over the global highlands. On a regional scale, Tmean and Tmax predominantly showed linear EDW over EU highlands, while Tmean in Asian highlands exhibited EDW signals at 4–5 km. Tmin showed EDW at 2.5–5.5 km with ERA5 and 3–5 km with CRU. In the Andes, EDW was prominent at 2.5–4 km. Overall, EDW signals are evident in all studied regions but vary across them. While assessing the driving factors, the results of this study indicate that total column water vapour (TCWV), snow depth (SD), snow albedo, and normalized difference vegetation index (NDVI) correlated positively with the temperature indicators. These findings emphasize the significance of elevation‐specific interactions between environmental factors and temperature in forecasting temperature changes in mountainous areas. Additionally, temperature exhibited coherence with teleconnection indices from the Atlantic and Pacific Oceans. Asian and European (EU) highlands exhibited interzonal coherence with the Pacific and Atlantic Oceans, while North American (NA) highlands showed coherence, followed by South American (SA) highlands. These findings provide a comprehensive understanding of EDW and its implications for highland regions globally, including the potential for more severe depletion of snow/ice resources in a warmer future.
Effects of rhamnolipid replacement of chlortetracycline on growth performance, slaughtering traits, meat quality and antioxidant function in broilers
Authors: Shi Yonghao , Zhou Qilu , Wu Chao , Liu Jinsong , Yang Caimei , Yang Ting , Zhang Ruiqiang 
Published: September 2024

AbstractBACKGROUNDRhamnolipids (RLS) are surfactants that improve the growth performance of poultry by improving the absorption of nutrients. This study aims to investigate the effects of RLS replacement of chlortetracycline (CTC) on growth performance, slaughtering traits, meat quality, antioxidant function and nuclear‐factor‐E2‐related factor 2 (Nrf2) signaling pathway in broilers. A total of 600 one‐day‐old Arbor Acres chicks were randomly assigned to five groups with eight replicates in each group, raised for 42 days. Broilers were respectively fed a basal diet with no CTC or RLS, 75 mg kg−1 CTC, and 250, 500, 1000 mg kg−1 RLS.RESULTSDietary supplementation with RLS linearly increased the average daily gain, average daily feed intake, carcass yield, eviscerated yield, ether extract, enhanced total superoxide and glutathione peroxidase (GPx) activities, overexpressed the relative expressions of Nrf2, heme oxygenase 1, Copper/zinc superoxide dismutase, Manganese superoxide dismutase, GPx and catalase and decreased the lightness value at 24 h, drip loss and malondialdehyde contents of broilers (P < 0.05). Compared with the control group, broilers fed 1000 mg kg−1 RLS reduced the drip loss and broilers fed 500 mg kg−1 RLS increased muscle crude fat content (P < 0.05). Compared with the CTC group, dietary supplementation with 1000 mg kg−1 RLS increased eviscerated yield (P < 0.05).CONCLUSIONRLS could improve growth performance, crude fat content, meat quality and antioxidant capacity and activate relative expression of genes in the Nrf2 signaling pathway in broilers. It could be used as an antibiotic substitute in diets and the recommended supplemental dose of RLS in feed of broilers is 1000 mg kg−1. © 2024 Society of Chemical Industry.
Narrow‐Band Imaging in Head and Neck Carcinomas: A Systematic Review and Meta‐Analysis
Authors: Fu Zi‐Yue , Li Da‐Peng , Shen Chuan‐Lu , Wang Jian‐Peng , Han Yan‐Xun , Chen Shan‐Wen , Ding Zhao , Zhang Lei , Liang Bing‐Yu , Yin Si‐Yue , Yang Yi‐Pin , Zhang Yu‐Lin , Li Yan , Liu Ye‐Hai , Pan Hai‐Feng , Wu Kai‐Le , Liu Yu‐Chen 
Published: September 2024

ObjectiveThe purpose of this study was to assess the diagnostic performance of narrow‐band imaging (NBI) in monitoring patients with head and neck carcinomas posttreatment and to compare it with that of white light endoscopy (WLE).Data SourcesPubMed, Embase, Web of Science (WOS), Cochrane Library, China Biology Medicine disc (CBM disc), China National Knowledge Internet (CNKI), Wanfang Data, China Science and Technology Journal Database (CSTJ), Chinese Clinical Trial Register.Review MethodsUsing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA), literature published before July 2024 was searched. Patients who underwent surgery, radiotherapy (RT), or chemo‐RT for head and neck carcinomas with posttreatment follow‐up using NBI were analyzed. The main outcomes were sensitivity, specificity, and diagnostic odds ratio (DOR) for NBI and WLE in posttreatment follow‐up.ResultsThe sensitivity, specificity, and DOR for NBI and WLE in posttreatment follow‐up for head and neck carcinomas were 95% (95% confidence interval [CI]: 88%–98%), 96% (95% CI: 92%–98%), 433 (95% CI: 120–1560) and 72% (95% CI: 49%–87%), 72% (95% CI: 4%–99%), 7 (95% CI: 0–191). Additionally, the area under the curve (AUC) values for NBI and WLE were 0.99 (95% CI: 0.97–0.99) and 0.75 (95% CI: 0.71–0.79), respectively. The number of lesions and patients, treatment modality, follow‐up time, disease, and endoscopic system might be sources of heterogeneity.ConclusionCompared to WLE, NBI demonstrated superior diagnostic performance in follow‐up patients with head and neck carcinoma posttreatment. NBI offers technical support and a clinical foundation for early detection of head and neck carcinoma recurrence.Level of EvidenceNA Laryngoscope, 2024
Existence of solutions for critical Neumann problem with superlinear perturbation in the half‐space
Authors: Deng Yinbin , Shi Longge , Zhang Xinyue 
Published: September 2024

AbstractIn this paper, we consider the existence and multiplicity of solutions for the critical Neumann problem

where , , , , , is the outward unit normal vector at the boundary , is the usual critical exponent for the Sobolev embedding and is the critical exponent for the Sobolev trace embedding . By establishing an improved Pohozaev identity, we show that problem () has no nontrivial solution if . Applying the mountain pass theorem without the condition and the delicate estimates for the mountain pass level, we obtain the existence of a positive solution for all and the different values of the parameters and . Particularly, for , , , we prove that problem () has a positive solution if and only if . Moreover, the existence of multiple solutions for () is also obtained by dual variational principle for all and suitable .
What, no logos? Why some minimalists prefer quiet luxury
Authors: Taylor Charles R. , Borenstein Benjamin , Pangarkar Aniruddha 
Published: September 2024

AbstractMinimalism is a philosophy based on reduction of consumption and holding fewer possessions that has gained great momentum and popularity worldwide. While prior literature suggests that not all minimalists engage in luxury consumption, a segment of minimalists labeled inconspicuous minimalists are theorized to not only focus on having fewer possessions, but also to have a preference for high product quality and subtlety in design that translates into a higher propensity to purchase “quiet luxury” products. This research empirically examines the relationship between inconspicuous minimalism and luxury consumption. In four experimental studies, we find that contrary to popular belief, certain minimalists are in fact likely to purchase luxury goods. Moreover, we find that inconspicuous minimalists prefer “quiet” versions of luxury brands that are more discreet (no logos), and that these luxury purchases are motivated by a desire for social connectedness to knowledgeable “elites” who share similar cultural capital and values. These findings suggest that inconspicuous minimalists are motivated by social factors, but not by traditional Veblen style conspicuous consumption motives in which the buyer has a desire to impress the masses.
Aortic aneurysm: pathophysiology and therapeutic options
Authors: Yang Guang , Khan Abbas , Liang Wei , Xiong Zibo , Stegbauer Johannes 
Published: September 2024

AbstractAortic aneurysm (AA) is an aortic disease with a high mortality rate, and other than surgery no effective preventive or therapeutic treatment have been developed. The renin–angiotensin system (RAS) is an important endocrine system that regulates vascular health. The ACE2/Ang‐(1–7)/MasR axis can antagonize the adverse effects of the activation of the ACE/Ang II/AT1R axis on vascular dysfunction, atherosclerosis, and the development of aneurysms, thus providing an important therapeutic target for the prevention and treatment of AA. However, products targeting the Ang‐(1–7)/MasR pathway still lack clinical validation. This review will outline the epidemiology of AA, including thoracic, abdominal, and thoracoabdominal AA, as well as current diagnostic and treatment strategies. Due to the highest incidence and most extensive research on abdominal AA (AAA), we will focus on AAA to explain the role of the RAS in its development, the protective function of Ang‐(1–7)/MasR, and the mechanisms involved. We will also describe the roles of agonists and antagonists, suggest improvements in engineering and drug delivery, and provide evidence for Ang‐(1–7)/MasR's clinical potential, discussing risks and solutions for clinical use. This study will enhance our understanding of AA and offer new possibilities and promising targets for therapeutic intervention.
Tumor‐associated exosomes in cancer progression and therapeutic targets
Authors: Liu Xiaomin , Wu Fan , Pan Wei , Liu Guangchao , Zhang Hui , Yan Dawei , Zheng Saijing , Ma Zhongliang , Ren Xiaojun 
Published: September 2024

AbstractExosomes are small membrane vesicles that are released by cells into the extracellular environment. Tumor‐associated exosomes (TAEs) are extracellular vesicles that play a significant role in cancer progression by mediating intercellular communication and contributing to various hallmarks of cancer. These vesicles carry a cargo of proteins, lipids, nucleic acids, and other biomolecules that can be transferred to recipient cells, modifying their behavior and promoting tumor growth, angiogenesis, immune modulation, and drug resistance. Several potential therapeutic targets within the TAEs cargo have been identified, including oncogenic proteins, miRNAs, tumor‐associated antigens, immune checkpoint proteins, drug resistance proteins, and tissue factor. In this review, we will systematically summarize the biogenesis, composition, and function of TAEs in cancer progression and highlight potential therapeutic targets. Considering the complexity of exosome‐mediated signaling and the pleiotropic effects of exosome cargoes has challenge in developing effective therapeutic strategies. Further research is needed to fully understand the role of TAEs in cancer and to develop effective therapies that target them. In particular, the development of strategies to block TAEs release, target TAEs cargo, inhibit TAEs uptake, and modulate TAEs content could provide novel approaches to cancer treatment.
Striding towards a greener future: Unlocking the potential of natural resources and employment dynamics in green energy transition in sub‐Saharan Africa
Authors: Okere Kingsley I. , Dimnwobi Stephen Kelechi , Fasanya Ismail O. 
Published: September 2024

AbstractThe adoption and utilization of renewable energy offer potential benefits such as enhanced energy efficiency, cost savings, and ecological advantages. However, a key research question addressed in this analysis is whether natural resource rent and employment dynamics influence renewable energy consumption in Africa. Previous research has predominantly focused on the aggregate employment rate, overlooking the nuances of labor diversity across sectors and employment types. Hence, this study evaluates the importance of natural resource rent and employment in driving the transition to green energy in sub‐Saharan Africa from 1991 to 2022. It employs the innovative method of moments quantile regression (MMQR) model for this purpose. The findings reveal a positive connection between natural resource rent and the adoption of green energy. When considering employment types, the study observes that self‐employment and wages/salaried workers undermine clean energy utilization. Moreover, the study highlights that employment across key economic sectors also plays a role. While employment in the agriculture and service sectors fosters green energy utilization, employment in the industrial sector impedes renewable energy consumption. To advance the development of green energy in Africa, this study underscores a range of policy options.
Does banking relationships promote environmental, social, and governance performance? Empirical evidence from A‐share listed firms in China
Authors: Wang Menghan , Zhao Qi , Gong Xiaoxiao 
Published: September 2024

AbstractThis study investigates the impact of banking relationships on corporate environmental, social, and governance (ESG) performance using data from A‐share listed firms in China from 2009 to 2019. Results show that banking relationships negatively impact corporate ESG performance. Mechanism analysis finds that banking relationships increase agency costs and financial investment, thereby diminishing ESG performance. Corporate executives with banking backgrounds and banks holding firm shares dampen ESG performance, whereas firms holding bank shares do not yield significant impact on ESG performance. Our study also finds that the negative impact of banking relationships on ESG performance is mitigated by analyst attention and supervisory institutional investors.
Machine‐learning‐assisted intelligent synthesis of UiO‐66(Ce): Balancing the trade‐off between structural defects and thermal stability for efficient hydrogenation of Dicyclopentadiene
Authors: Lin Jing , Ban Tao , Li Tian , Sun Ye , Zhou Shenglan , Li Rushuo , Su Yanjing , Kasemchainan Jitti , Gao Hongyi , Shi Lei , Wang Ge 
Published: September 2024

AbstractMetal‐organic frameworks (MOFs), renowned for structural diversity and design flexibility, exhibit potential in catalysis. However, the pursuit of higher catalytic activity through defects often compromises stability, requiring a delicate balance. Traditional trial‐and‐error method for optimizing synthesis parameters within the complex chemical space is inefficient. Herein, taking the typical MOF UiO‐66(Ce) as an illustrative example, a closed loop workflow is built, which integrates machine learning (ML)‐assissted prediction, multi‐objective optimization (MOO) and experimental preparation to synergistically optimize the defect content and thermal stability of UiO‐66(Ce) for efficient hydrogenation of dicyclopentadiene (DCPD). An automatic data extraction program ensures data accuracy, establishing a high‐quality database. ML is employed to explore the intricate synthesis‐structure‐property correlations, enabling precise delineation of pure‐phase subspace and accurate predictions of properties. After two iterations, MOO model identifies optimal protocols for high defect content (>40%) and thermal stability (>300°C). The optimized UiO‐66(Ce) exhibits superior catalytic performance in hydrogenation of DCPD, validating the precision and reliability of our methodology. This ML‐assisted approach offers a valuable paradigm for solving the trade‐off riddle in materials field.
Initiation of noninvasive ventilation in patients with amyotrophic lateral sclerosis
Authors: Jimenez Jose Victor , Tang Michael J. , Wilson Mathew W. , Morrison Alexander H. , Ackrivo Jason , Choi Philip J. 
Published: September 2024

AbstractIntroduction/AimsNoninvasive ventilation (NIV) has been shown to improve survival and symptom burden in patients with amyotrophic lateral sclerosis (ALS). However, limited data exist regarding the clinical and physiological parameters at the time of NIV initiation. This study aimed to describe the clinical characteristics and respiratory physiological markers in a cohort of ALS patients with chronic respiratory failure.MethodsThis is a single‐center retrospective cohort study of patients with ALS assessed for NIV initiation between February 2012 and January 2021. NIV was initiated based on insurance eligibility criteria: daytime hypercapnia, defined by partial pressure of carbon dioxide (PaCO2) >45 mm Hg using diurnal transcutaneous CO2 (TcCO2) as a surrogate, a maximal inspiratory pressure (MIP) <60 cmH2O or forced vital capacity (FVC) <50% predicted normal.ResultsWe identified 335 patients with ALS and chronic respiratory failure referred to an outpatient home ventilation clinic for NIV initiation. The mean age was 64 years ±11; 151 (45%) were female, 326 (97%) were white, and 100 (29%) had bulbar‐onset ALS. At the time of NIV initiation, the mean FVC was 64% ± 19%, the mean MIP; 41 cmH2O ± 17, and diurnal TcCO2; 40 ± 6 mmHg. The most common reasons for NIV initiation were MIP <60 cmH2O (58%) and multiple concomitant indications (28%). Within 1 year of NIV initiation, 126 (37%) patients were deceased.DiscussionWe found that impairment in inspiratory force was the most common reason for NIV initiation and often preceded significant declines in FVC.
Personal and Social‐Built Environmental Factors of Glucose Variability Among Multiethnic Groups of Adults With Type 2 Diabetes: Research Protocol Using Ecological Momentary Assessment, Continuous Glucose Monitoring, and Actigraphy
Authors: Nam Soohyun , Jeon Sangchoon , Ash Garrett I. , Weinzimer Stuart , Dunton Genevieve F. , Parekh Niyati , Grey Margaret , Chen Kai , Lee Minjung , Sajdlowska Anna , Whittemore Robin 
Published: September 2024

ABSTRACTGlucose variability (GV)—the degree of fluctuation in glucose levels over a certain period of time—is emerging as an important parameter of dynamic glycemic control. Repeated glycemic oscillations have been reported to be the link to diabetes complications. This prospective observational study aims to: (1) identify multilevel risk factors (personal and social‐built environmental factors) associated with high GV; (2) identify “within‐person predictors” of high GV leveraging the intra‐person data to inform future personalized diabetes interventions; and (3) examine which lifestyle factors either mediate or moderate the relationship between emotional well‐being and GV among diverse adults with type 2 diabetes (T2D). We will recruit 200 adults with T2D from the community. All participants will complete baseline surveys assessing demographics, lifestyle, social‐built environmental, and clinical factors. Real‐time dynamic glucose levels will be measured using continuous glucose monitoring (CGM). Sleep, physical activity, diet/eating, and emotional well‐being will be measured with an actigraphy device and a real‐time self‐report tool (ecological momentary assessment [EMA]) across 14 days. Two 24‐h dietary recall data will be collected by online video calls. Generalized linear models, multilevel models, and structural equation models will be developed to achieve the study aims. The findings from the study will identify high‐risk groups of high GV who would benefit from CGM to improve diabetes outcomes and inform the future development of personalized just‐in‐time interventions targeting lifestyle behaviors with an increased understanding of GV and by supporting healthcare providers' clinical decisions.