bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response to afatinib, after gefitinib and erlotinib, in a patient with advanced adenocarcinoma of lung with brain metastasis: A case report
Authors: Mehta Prashant , Bhajoni Pranjit Santonu , Mehta Swati Pabbi 
Published: January 2017

<p style="margin-bottom: 0.14in; line-height: 115%;" align="justify"><span lang="en-US">Non-small-cell lung cancer (NSCLC) accounts for 80–85% of all lung cancer cases. The majority of patients present with advanced disease. Adenocarcinoma of the lung forms one of the major histopathological subtypes of metastatic NSCLC. A</span><span> </span><span lang="en-US">70-year-old male was diagnosed with adenocarcinoma right lung with clinical staging of cT</span><span class="Subscript CharOverride-1" lang="en-US">2</span><span lang="en-US">N</span><span class="Subscript CharOverride-1" lang="en-US">0</span><span lang="en-US">M</span><span class="Subscript CharOverride-1" lang="en-US">0 </span><span lang="en-US">in 2012. Patient was treated with adjuvant chemotherapy with 4</span><span> cycle</span><span lang="en-US">s of vinorelbine and cisplatin followed by image guided radiation therapy that was completed in November 2012. The patient was started on gefitinib in Jan 2014 till January 2015 due to recurrence and progression and was subsequently switched to erlotinib as the gefitinib was becoming ineffective. However, the patient developed toxicity leading to diarrhea, and the patient had to discontinue erlotinib. In view of poor general condition of the patient (ECOG performance status 4), and progression post gefitinib and erlotinib he was deemed unfit for chemotherapy and it was decided to start the patient on afatinib 40</span><span> mg</span><span lang="en-US"> once a day in July 2015, to which the patient responded. The patient showed significant improvement on afatinib. The response though partial and incomplete was substantial and further improvement was very much expected unfortunately the patient succumbed to a lower respiratory tract infection in November 2015.</span></p>
Putting viruses to work in CAR therapies
Authors: Mehta Divyesh G. 
Published: January 2017

<div>The difference between the patient who gets cured after surgery, chemotherapy and event targeted therapies and who relapses with a small quantum of intrepid cancer cells is whether the Dendritic cell T cell complex could find and eliminate residual minimal tumour load. A very significant chapter in these battles has opened up with the Chimeric Antigen Receptor (CAR) Therapy. Many B cell Neoplasms express CD19. CARs can be engineered into viruses and expressed by T cells. CAR T cells with anti CD19 faculties can be transferred to the patient. This novel therapy shows many promises and raises new questions.</div>
УПОТРЕБА КЊИЖЕВНОГ ТЕКСТА У НАСТАВИ (СРПСКОГ КАО СТРАНОГ) ЈЕЗИКА
Authors: Перишић Јелена Р. 
Published: January 2017

У оквиру наставе страног језика важно место има повезивање садржаја из језика и књижевности, тачније употреба књижевних текстова на часовима намењеним усвајању језичких јединица. Како би се откриле пожељне особине књижевног текста за потребе наставе српског језика као страног и најбољи начини његове примене, најпре ће се представити ранија разматрања у вези са овом темом и захтеви које прописује Заједнички европски оквир за живе језике[1], а затим дати предлози текстова и њихове обраде на различитим нивоима учења.

[1] Документ Савета Европе познат под називом Заједнички европски референтни оквир за живе језике (енг. Common European framework of Reference for Languages) чини данас заједничку базу за израду програма, уџбеника и проверу знања у настави страних језика у Европи. У њему се објашњава како се учи страни језик за потребе комуникације, указује на значај културног контекста у учењу страних језика и дефинишу нивои компетенције (А1, А2, Б1, Б2, Ц1, Ц2) који омогућавају праћење постигнућа у учењу у различитим фазама живота појединаца на исти начин у целој Европи. Као радна верзија постојао је 1995. године, а 1997. Савет Европе га је званично усвојио и објавио на интернету. Верзија на енглеском и француском појавила се 2001, а године 2003. превод на српски језик објавило је Министарство просвјете и науке Републике Црне Горе (Ђоровић 2011: 822).
USVAJANJE NOVIH REČI ENGLESKOG JEZIKA KAO STRANOG I POBOLJŠANJE GOVORNE KOMPETENCIJE U VEZI SA ODREĐENOM TEMOM PRIMENOM „PRISTUPA UČENJU KROZ KOMUNIKATIVNE ZADATKE“
Authors: Petrović Vesna M. 
Published: January 2017

U ovom radu se ocenjuju ishodi učenja novih reči kroz upotrebu komunikativnih jezičkih zadataka kod studenata koji engleski jezik uče kao strani. U proces učenja uvedena je diskusija kao tip komunikativnog zadatka da bi se omogućila upotreba jezika u smisaonom i prirodnom okruženju. Usmeni i pismeni delovi ciklusa zadatka u vezi sa zadatom temom diskusije urađeni su u obliku intervjua u parovima na nivou grupe, a njihovi odgovori su analizirani kroz dijagnostičke liste. Tačnost u izgovoru i pisanju novih reči i izraza su, takođe, uzeti u obzir u okviru analize. Ovi rezultati su predmet analize sadržaja koja je tipična za kvantitativna istraživanja. U radu je prikazana i kvalitativna analiza da bi se procenila motivacija i spremnost učenika da učestvuju u izradi komunikativnih zadataka.
Development and Validity of Fluid Intelligence Test Based on Cattle-Horn-Carrol Theory: A Pilot Project
Authors: Andriani Fitri , Hadi Cholichul , Paramita Pramesti Pradna 
Published: January 2017

This study aimed to examine the validity of the Fluid Intelligence Test, constructed based on the Cattel-Horn-Carroll theory. There were two sources of validity used in this study, which were evidence based on the internal structure and evidence based on relation with other variables. Sixty-four items have been composed and tested to 242 people. The data was analyzed using confirmatory factor analysis technique and correlations technique to examine test validity. The result of this study showed that the prepared model worked quite well in describing the narrow abilities of fluid intelligence, as showed by the receipt of fit indexes accuracy of the model, such as Chi-Square value .42 (p = .518), Goodness Fit Index (GFI) = 1, and Rooted Mean Square Error (RMSEA) = .00. Similar result was also showed by its correlation with other variables, which are .717 (TIKI) and .606 (CFIT). This suggested that Fluid Intelligence Test has good validity.
Deteksi Dini Masalah Psikologis Pada Anak Jalanan Oleh Orangtua Asuh di Rumah Singgah
Authors: Suryanto Suryanto , Herdiana Ike , Chusairi Achmad 
Published: January 2017

Tujuan dari penelitian ini adalah melakukan deteksi dini permasalahan anak jalanan yang berada di rumah singgah. Penelitian ini menggunakan pendekatan kualitatif. Partisipan adalah lima pengasuh dari tiga rumah singgah anak jalanan di Surabaya. Metode pengambilan data adalah Focus Group Discussion (FGD). Hasil penelitian menunjukkan; (1) perilaku spesifik anak: mengganggu teman, malas, banyak bermain, memegang alat vital temannya, berkata kotor, motivasi belajar rendah, membangkang, memukul teman, keras kepala, kesulitan belajar; (2) perilaku bermasalah: anak yang mengancam bunuh diri; (3) interaksi anak dengan orangtua asuh: baik, intens, pengasuh terlibat membantu mengatasi masalah anak; (4) permasalahan emosional anak: mudah marah, tersinggung, kurang terbuka, membentak teman dan pendamping, memukul teman, emosional saat bicara, cemas, marah, perasaan bersalah dan sedih; (5) faktor penyebab anak asuh bermasalah: pergaulan, lingkungan sekolah, kurangnya afeksi orangtua, kurangnya minat belajar, perilaku kekerasan yang diterima anak dari orangtua kandung, kemiskinan dan keluarga tidak harmonis.
SINTESIS NANOSELULOSA DARI SERAT NANAS DAN APLIKASINYA SEBAGAINANOFILLERPADA FILM BERBASIS POLIVINIL ALKOHOL
Authors: Iriani Evi Savitri , Wahyuningsih Kendri , Sunarti Titi Candra , Permana Asep Wawan 
Published: January 2017

<p>A variety of attempts have been made to reduce the dependence on petroleum raw materials based plastics which are limited supply the mechanical properties close to conventional plastic. The objectives of research was to know the effect of pineapple nanocellulose effective in increasing tensile strength and elongation, but the higher addition (of up to 50%) resulted in decreased elongation. The addition and without glycerol</p>
DAYA SIMPAN BUAH MANGGIS (Garcinia mangostana L.) PADA BERBAGAI TINGKAT KETUAAN DAN SUHU PENYIMPANAN
Authors: Setyabudi Dondy , Widayanti S. M , Prabawati Sulusi 
Published: January 2017

The aim of research provides information physicochemical characters of three levels of maturity picking of mangosteen fruit in storage at both low and ambient storage temperature. Mangosteen fruit was obtained from production centers in villages Puspahiang, Puspahiang, Tasikmalaya and Wanayasa, Purwakarta, West Java. Sampling sites was used as block with twice sampling at each location. Mangosteen fruit picked at the three levels of stages of maturity detected by color; a) Maturity-1: green red spots, b) Maturity-2: breaker
red”cumolat” 10-25%, and c) Maturity-3: 25-50% red-purple spots. The maturity was based on the color of the assumed age of farmers as picking at 106, 108, and 110 days after bloom (DAB). Further mangosteen fruit was stored at ambient temperature 27-29 °C and at low temperature 9 ± 1 °C. Observations were made on physical and chemical properties at intervals of 0, 3, 6 days, until the samples were not accepted by panelis. Analysis of physical properties include withered sepals, weight loss, skin color of fruit, and mangosteen rind characteristics using scanning electronic microscope/SEM. Meanwhile, the chemical properties include vitamin C, total acid, and total soluble solids. The results showed that the stage maturity 108 days (maturity-2 break color 10-25%) has a 12 day shelf life with characteristics withered sepals 2.61; weight loss of 3.80%; vitamin C 60.01 mg/100 g, total soluble solids 17.35%, and 0.41% total acid is the best stage picking compared to other stage picking. The maturity of the mangosteen fruit picking 108 days after blooming (maturity-2) with these characteristics was expected to be used for determining the proper maturity for picking suitable for export.
EFIKASI CUKA KULIT PISANG DAN AIR KELAPA SEBAGAI PENGHAMBAT Listeria monocytogenes PADA DAGING AYAM
Authors: Widaningrum Widaningrum , Miskiyah Miskiyah , Juniawati Juniawati 
Published: January 2017

Providing natural preservatives to increase the shelf life of chicken meat is a challenge, since the microbial contaminants problem has been a concern among many actors: government, business, consumers, and health practitioners. Acetic acid (known as vinegar) has properties as an antimicrobial, due to its ability to lower the pH and causing instability in the cell membrane of pathogenic bacteria. This paper aimed to assess the manufacture of vinegar from banana peel and coconut water as potentially natural preservative, and
its application to determine the effect of microbial growth inhibition of Listeria monocytogenes in chicken meat. The study was designed using a randomized factorial design with 2 factors: 1. Types of vinegar (banana peel, coconut water, commercial acetic acid and commercial lactic acid) and 2. Storage temperature (room temperature and refrigerated temperature 5-7° C), each were repeated
three times. Chicken meat that has been treated with acid soaking then stored at room temperature and cold temperatures. The results showed that banana peel and coconut water vinegar inhibit the growth of testing bacteria L. monocytogenes in chicken meat stored at
room temperature more effective (5-6 log CFU/g) than the commercial acetic acid and commercial lactic acid (7-8 log CFU/g), for 24 hours storage. In chicken meat stored in cold temperatures, banana peel and coconut water vinegar had almost the same capabilities with commercial acetic acid (5.34 log CFU/g) on storage for 12 days. The most potential vinegar to be used in refrigerated temperature
was banana peel vinegar.
O projeto Porto Maravilha e o rent gap de Neil Smith
Authors: Martins Renato Domingues Fialho 
Published: January 2017

Resumo: A Operação Urbana Consorciada (OUC) Porto Maravilha refere-se a um conjunto de intervenções urbanísticas, viárias, imobiliárias e financeiras na zona portuária do Rio de Janeiro, levado a cabo por um consórcio que envolve o poder público municipal e grandes empreiteiras transnacionais. Trata-se de uma operação urbana de evidente destaque, sendo a maior parceria público-privada do país. O objetivo deste artigo é analisar a OUC Porto Maravilha a partir da formulação teórica do rent gap, proposta por Neil Smith, e a consequente discussão sobre o conceito de gentrificação. A ideia é verificar se a teoria do rent gap pode ajudar a compreender esse grupo de intervenções urbanas. Além disso, pretende-se examinar os limites e virtudes do rent gap. Várias questões são consideradas no estudo, tais como: (1) é possível importar uma teoria formulada para cidades de países centrais e aplicá-la na experiência carioca? Em caso positivo, (2) quais distinções devem ser sublinhadas e quais precauções precisam ser tomadas?Palavras-chave: Porto Maravilha; gentrificação; rent gap; empreendedorismo urbano. The Porto Maravilha project and the Neil Smith’s rent gap theoryAbstract: The Operação Urbana Consorciada (OUC) Porto Maravilha refers to a set of urban interpositions on roads, real state and financial apport in the port area of Rio de Janeiro. The interpositions are performed by a consortium involving the municipal government and transnational contractors. The urban operation in question stands out from others because this is the largest brazilian public-private partnership. The aim of this paper is to perform an analysis of the OUC Porto Maravilha from the theoretical rent gap formulation proposed by Neil Smith with the consequent discussion about the concept of gentrification. The purpose is to make sure that it can help to understand the urban interventions in Rio. In addition, it intends to examine the limits and virtues of the the rent gap. There are several issues to consider: Is it possible to “import” a theory formulated to cities of core countries and apply it in Rio experience? If so, what are the distinctions and precautions that should be outlined?Keywords: Porto Maravilha; gentrification; rent gap; urban entrepreneurship.
A novel weighted scoring system for estimating the risk of rapid growth in untreated intracranial meningiomas
Authors: Lee Eun Jung , Kim Jeong Hoon , Park Eun Suk , Kim Young-Hoon , Lee Jae Koo , Hong Seok Ho , Cho Young Hyun , Kim Chang Jin 
Published: January 2017

OBJECTIVEAdvances in neuroimaging techniques have led to the increased detection of asymptomatic intracranial meningiomas (IMs). Despite several studies on the natural history of IMs, a comprehensive evaluation method for estimating the growth potential of these tumors, based on the relative weight of each risk factor, has not been developed. The aim of this study was to develop a weighted scoring system that estimates the risk of rapid tumor growth to aid treatment decision making.METHODSThe authors performed a retrospective analysis of 232 patients with presumed IM who had been prospectively followed up in the absence of treatment from 1997 to 2013. Tumor volume was measured by imaging at each follow-up visit, and the growth rate was determined by regression analysis. Predictors of rapid tumor growth (defined as ≥ 2 cm3/year) were identified using a logistic regression model; each factor was awarded a score based on its own coefficient value. The probability (P) of rapid tumor growth was estimated using the following formula:RESULTSFifty-nine tumors (25.4%) showed rapid growth. Tumor size (OR per cm3 1.07, p = 0.000), absence of calcification (OR 3.87, p = 0.004), peritumoral edema (OR 2.74, p = 0.025), and hyperintense or isointense signal on T2-weighted MRI (OR 3.76, p = 0.049) were predictors of tumor growth rate. In the Asan Intracranial Meningioma Scoring System (AIMSS), tumor size was categorized into 3 groups of < 2.5 cm, ≥ 2.5 to < 4.0 cm, and ≥ 4.0 cm in diameter and awarded a score of 0, 3, and 6, respectively; the parameters of calcification and peritumoral edema were categorized into 2 groups based on their presence or absence and given a score of 0 or 2 and 1 or 0, respectively; and the signal on T2-weighted MRI was categorized into 2 groups of hypointense and hyperintense/isointense and given a score of 0 or 2, respectively. The risk of rapid tumor growth was estimated to be < 10% when the total score was 0–2, 10%–50% when the total score was 3–6, and ≥ 50% when the total score was 7–11 (Hosmer-Lemeshow goodness-of-fit test, p = 0.9958). The area under the receiver operating characteristic curve was 0.86.CONCLUSIONSThe authors suggest a weighted scoring system (AIMSS) that predicts the specific probability of rapid tumor growth for patients with untreated IM. This scoring system will aid treatment decision making in clinical settings by screening out patients at high risk for rapid tumor growth.
Radical chemistry at a rural site (Wangdu) in the North China Plain: observation and model calculations of OH, HO2 and RO2 radicals
Authors: Tan Zhaofeng , Fuchs Hendrik , Lu Keding , Hofzumahaus Andreas , Bohn Birger , Broch Sebastian , Dong Huabin , Gomm Sebastian , Häseler Rolf , He Lingyan , Holland Frank , Li Xin , Liu Ying , Lu Sihua , Rohrer Franz , Shao Min , Wang Baolin , Wang Ming , Wu Yusheng , Zeng Limin , Zhang Yinsong , Wahner Andreas , Zhang Yuanhang 
Published: January 2017

Abstract. A comprehensive field campaign was carried out in summer 2014 in Wangdu, located in the North China Plain. A month of continuous OH, HO2 and RO2 measurements was achieved. Observations of radicals by the laser-induced fluorescence (LIF) technique revealed daily maximum concentrations between (5–15)  × 106 cm−3, (3–14)  × 108 cm−3 and (3–15)  × 108 cm−3 for OH, HO2 and RO2, respectively. Measured OH reactivities (inverse OH lifetime) were 10 to 20 s−1 during daytime. The chemical box model RACM 2, including the Leuven isoprene mechanism (LIM), was used to interpret the observed radical concentrations. As in previous field campaigns in China, modeled and measured OH concentrations agree for NO mixing ratios higher than 1 ppbv, but systematic discrepancies are observed in the afternoon for NO mixing ratios of less than 300 pptv (the model–measurement ratio is between 1.4 and 2 in this case). If additional OH recycling equivalent to 100 pptv NO is assumed, the model is capable of reproducing the observed OH, HO2 and RO2 concentrations for conditions of high volatile organic compound (VOC) and low NOx concentrations. For HO2, good agreement is found between modeled and observed concentrations during day and night. In the case of RO2, the agreement between model calculations and measurements is good in the late afternoon when NO concentrations are below 0.3 ppbv. A significant model underprediction of RO2 by a factor of 3 to 5 is found in the morning at NO concentrations higher than 1 ppbv, which can be explained by a missing RO2 source of 2 ppbv h−1. As a consequence, the model underpredicts the photochemical net ozone production by 20 ppbv per day, which is a significant portion of the daily integrated ozone production (110 ppbv) derived from the measured HO2 and RO2. The additional RO2 production from the photolysis of ClNO2 and missing reactivity can explain about 10 % and 20 % of the discrepancy, respectively. The underprediction of the photochemical ozone production at high NOx found in this study is consistent with the results from other field campaigns in urban environments, which underlines the need for better understanding of the peroxy radical chemistry for high NOx conditions.
Pragmatism, Racial Solidarity, and Negotiating Social Practices: Evading the Problem of “Problem Solving” Talk
Authors: Wolfe Kevin 
Published: January 2017

Abstract
In his review of Eddie Glaude's Exodus! “Politics, Racial Solidarity, Exodus!” Robert Gooding-Williams argues that, despite sympathizing with Glaude's conception of racial solidarity, he finds that “Glaude's approach to racial solidarity is not pragmatic enough, precisely because the myth of the essential black subject still haunts it, its claims to the contrary notwithstanding.” This article challenges Gooding-Williams's reading of Exodus!, demonstrating that despite his grasp of Glaude's conceptual map, he misses precisely what is at stake for Glaude's pragmatic notion of racial solidarity. Understanding what is at stake for Glaude's conception of racial solidarity, one sees how the subtlety of his pragmatism actually resists any lingering essentialism. However, this article concludes by showing that despite Glaude's evasion of Gooding-Williams's charge, it is his emphasis on the Deweyan language of “problem solving” that courts the criticism in the first place. To circumvent the potential for misunderstanding, this article emphasizes a “negotiation of social practices” as an alternative to Glaude's emphasis on the language of “problem solving activity.”
“Through a Glass, Darkly”: Evidence for Knowledge of Pseudo-Dionysius in Anglo-Saxon England
Authors: Flight Tim 
Published: January 2017

Abstract
Despite his importance to later English medieval spirituality, the possibility of Pseudo-Dionysius's influence in Anglo-Saxon England remains unresolved, having been merely subjected to brief speculation. This article quantifies Pseudo-Dionysius's potential influence by tracing all evidence for Anglo-Saxon contact with the Corpus Areopagitum. Using Stock's model of “textual communities,” it reviews the study of Pseudo-Dionysius at Rome and the Carolingian court and discusses the level of intellectual exchange between Anglo-Saxon England and these Continental centers, with particular focus on Israel the Grammarian. It then discusses the unacknowledged presence of Pseudo-Dionysius's thought in Anglo-Saxon manuscripts and analyzes Hilduin's exposition of his theology in Passio Sancti Dionysii. It concludes that Pseudo-Dionysius was an influence on Anglo-Saxon thought. Beyond signaling the need for his influence on Anglo-Saxon spirituality and texts to be reconsidered, this article's suggestion of Pseudo-Dionysius's preconquest influence has implications for the accepted history of English medieval spirituality.
Julian of Norwich and the Muttering Fiend
Authors: Spellmire Adam 
Published: January 2017

Abstract
Scholars emphasize Julian of Norwich's serenity, contrasting her work and its confidence that “all shall be well” with medieval writing more interested in Hell's torments. This serenity distinguishes her, scholars note, from her contemporaries Chaucer and Langland and their fascination with the world's confusion. Julian's confrontation with an unintelligible, muttering fiend near the end of her book, however, reveals similar anxieties in her own writing. Julian indeed avoids dwelling on eternal punishment, but this incoherent attacker jeopardizes her efforts to interpret her revelations and make sense of the world.