bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breech presentation: its predictors and consequences. An analysis of the Hungarian Tauffer Obstetric Database (1996–2011)
Authors: Zsirai László , Csákány György M. , Vargha Péter , Fülöp Vilmos , Tabák Ádám G. 
Published: December 2015

AbstractIntroductionBreech presentation is linked to abnormal pregnancy outcomes. However, the causality of this association is unknown. We aimed to investigate predictors of term breech presentation and pregnancy outcomes of breech presentation.Material and methodsUsing a Hungarian registry, all term (≥ 37 weeks), singleton pregnancies with cephalic, and breech presentation in 1996–2011 were analyzed (n = 41 796). Covariates were maternal medical history and data on the present pregnancy. Multivariable logistic regression was used to investigate predictors of breech presentation and of delivery (cesarean section or other obstetrical interventions at birth) and fetal outcomes (Apgar score ≤ 7, need for perinatal intensive treatment, intrauterine death or perinatal mortality) related to breech presentation.ResultsBreech presentation was independently associated with older maternal age, medical history (primiparity, stillbirth, spontaneous abortion, hormone treatment, and assisted reproduction), maternal morbidities (hypertension and oligohydramnios), and the fetal factors (female sex, younger gestational age at delivery, developmental abnormalities, small for gestational age, and birthweight). An adverse delivery outcome was 11.7 times (95% confidence interval 11.3–12.0) and an adverse fetal outcome was 1.39 times (95% confidence interval 1.33–1.45) more frequent in pregnancies with breech presentation compared with cephalic presentation. Further adjustment for predictors of breech presentation had no major effect on the delivery outcome, but it reduced the risk of adverse fetal outcome (odds ratio 1.18, 95% confidence interval 1.14–1.24).ConclusionsBreech presentation is a marker of pathological pregnancy and is independently associated with an increased risk of gestational complications. Closer surveillance and appropriate management of pregnancies with breech presentation is warranted to prevent adverse perinatal outcomes.
Spontaneous regression of CIN2 in women aged 18–24 years: a retrospective study of a state‐wide population in Western Australia
Authors: Munro Aime , Powell Rhys G. , A. Cohen Paul , Bowen Shirley , Spilsbury Katrina , O'Leary Peter , Semmens James B. , Codde Jim , Williams Vincent , Steel Nerida , Leung Yee 
Published: December 2015

AbstractIntroductionCIN2 has a high rate of spontaneous regression in young women and may be managed conservatively in appropriately selected patients. This study aimed to investigate health outcomes in women aged 18–24 years with biopsy‐confirmed CIN2.Material and methodsA retrospective cohort study of Western Australian women aged 18–24 years diagnosed with CIN2 on cervical biopsy from 1 January 2001 to 31 December 2010. Women who had not received treatment at ≥4 months following CIN2 diagnosis were classified as managed ‘conservatively’. Subsequent cervical cytology and/or biopsy test results were used to report lesion regression (absence of dysplasia or an epithelial lesion of lower grade than CIN2) and disease persistence (CIN2, CIN3 or ACIS).ResultsFollow‐up data were available for 2417 women of whom 924 (38.2%) were ‘conservatively’ managed. In all, 152 (16.4%) conservatively managed women had a lesion more severe than CIN2 detected within 24 months of initial diagnosis, of which 144 were CIN3 and eight were ACIS. There was no statistically significant association between rates of regression and patient age, Socio‐economic Indexes for Areas or Accessibility/Remoteness Index of Australia indices. The 2‐year regression rate for CIN2 was estimated to be 59.5% (95%CI 0.5–0.6) in this cohort of women.ConclusionIn conservatively managed young women with CIN2 there was a high rate of spontaneous disease regression. Thus, excisional or ablative treatments may be avoided in selected patients who receive appropriate counseling and who are able to comply with more intensive and prolonged follow‐up requirements.
Comparing the performance of a new disposable pneumatic tocodynamometer with a standard tocodynamometer
Authors: Eswaran Hari , Wilson James D. , Murphy Pam , Siegel Eric R. , Lowery Curtis L. 
Published: December 2015

AbstractIntroductionThe goal was to test a newly developed pneumatic tocodynamometer (pTOCO) that is disposable and lightweight, and evaluate its equivalence to the standard strain gauge‐based tocodynamometer (TOCO).Material and methodsThe equivalence between the devices was determined by both mechanical testing and recording of contractile events on women. The data were recorded simultaneously from a pTOCO prototype and standard TOCO that were in place on women who were undergoing routine contraction monitoring in the Labor and Delivery unit at the University of Arkansas for Medical Sciences. In this prospective equivalence study, the output from 31 recordings on 28 pregnant women that had 171 measureable contractions simultaneously in both types of TOCO were analyzed. The traces were scored for contraction start, peak and end times, and the duration of the event was computed from these times.ResultsThe response curve to loaded weights and applied pressure were similar for both devices, indicating their mechanical equivalence. The paired differences in times and duration between devices were subjected to mixed‐models analysis to test the pTOCO for equivalence with standard TOCOs using the two‐one‐sided tests procedure. The event times and duration analyzed simultaneously from both TOCO types were all found to be significantly equivalent to within ±10 s (all p‐values ≤0.0001).ConclusionpTOCO is equivalent to the standard TOCO in the detection of the timing and duration of uterine contractions. pTOCO would provide a lightweight, disposable alternative to commercially available standard TOCOs.
Glucose tolerance in obese pregnant women determines newborn fat mass
Authors: Carlsen Emma M. , Renault Kristina M. , Nørgaard Kirsten , Nilas Lisbet , Jensen Jens‐Erik B. , Hitz Mette F. , Michaelsen Kim F. , Cortes Dina , Pryds Ole 
Published: December 2015

AbstractIntroductionOffspring of obese women have both short‐term and long‐term increased morbidities. We investigated the relationship between maternal 2‐h plasma glucose level determined by an oral glucose tolerance test, degree of obesity, gestational weight gain and total fat, abdominal fat, and fat‐free masses in the offspring of obese mothers.Material and methodsObese mother–newborn dyads were recruited and 2‐h plasma glucose levels were assessed during gestational weeks 27–30; neonatal body composition was measured by dual‐energy X‐ray absorptiometry scanning (DXA) within 48 h of birth.ResultsAmong 264 term, healthy, and singleton infants eligible for inclusion, 248 were included. Of these, 205 (83%) obese mother–newborn dyads had aDXAscan and 2‐h plasma glucose measurements. Linear regression analysis showed that birthweight z‐scores correlated with 2‐h plasma glucose levels (p= 0.002) after adjusting for gestational weight gain, maternal age, education, smoking, prepregnancy degree of obesity, parity, and birth length. Total (p= 0.012) and abdominal (p= 0.039) fat masses correlated with 2‐h plasma glucose levels after adjusting for gestational weight gain, maternal age, education, smoking, prepregnancy degree of obesity, parity, gestational age, and newborn sex. There was no association between total (p= 0.88) and abdominal (p= 0.61) fat‐free masses and 2‐h plasma glucose.ConclusionAt 27–30 weeks of gestation, 2‐h plasma glucose levels are related to total and abdominal newborn fat masses, but not to fat‐free mass. Interventions targeting maternal postprandial glucose levels may induce more appropriate birthweight, thereby reducing the risk of subsequent morbidity.
The intake of selected foods by six‐year‐old Swedish children differs according to parental education and migration status
Authors: Säfsten Eleonor , Nyberg Gisela , Elinder Liselotte Schäfer , Norman Åsa , Patterson Emma 
Published: December 2015

AbstractAimLittle is known about how parental migration status may be associated with children's diets. We examined whether the intake of selected foods by six‐year‐old children differed according to their parents’ migration status, taking education level into account.MethodsThis study used pooled baseline data from two clustered randomised controlled trials of A Healthy School Start, conducted in municipalities of low‐to‐medium socio‐economic status in Stockholm County, Sweden. The children's intake of selected healthy and unhealthy foods was reported by parents using the Eating and Physical Activity Questionnaire, and the children's height and weight were measured. Parental education and country of birth were self‐reported.ResultsData were available for 520 children. Low parental education was associated with significantly higher intakes of fruit, higher intakes of several unhealthy foods and lower intakes of vegetables. Children of parents born outside the Nordic region had higher intakes of all unhealthy foods as well as fruit and vegetables, even when adjusted for education. A negative association between high education and overweight was only seen in children of Nordic‐born parents.ConclusionParental migration status was a strong predictor of the intake of selected foods and was a stronger predictor than parental education.
Rituximab plus hyper‐CVAD alternating with MTX/Ara‐C in patients with newly diagnosed mantle cell lymphoma: 15‐year follow‐up of a phase II study from the MD Anderson Cancer Center
Authors: Chihara Dai , Cheah Chan Y. , Westin Jason R. , Fayad Luis E. , Rodriguez Maria A. , Hagemeister Fredrick B. , Pro Barbara , McLaughlin Peter , Younes Anas , Samaniego Felipe , Goy Andre , Cabanillas Fernando , Kantarjian Hagop , Kwak Larry W. , Wang Michael L. , Romaguera Jorge E. 
Published: December 2015

SummaryIntensive chemotherapy regimens containing cytarabine have substantially improved remission durability and overall survival in younger adults with mantle cell lymphoma (MCL). However, there have been no long‐term follow‐up results for patients treated with these regimens. We present long‐term survival outcomes from a pivotal phase II trial of rituximab, hyper‐fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with methotrexate and cytarabine (R‐HCVAD/MA). At 15 years of follow‐up (median: 13·4 years), the median failure‐free survival (FFS) and overall survival (OS) for all patients was 4·8 years and 10·7 years, respectively. The FFS seems to have plateaued after 10 years, with an estimated 15‐year FFS of 30% in younger patients (≤65 years). Patients who achieved complete response (CR) after 2 cycles had a favourable median FFS of 8·8 years. Six patients developed myelodysplastic syndrome/acute myeloid leukaemia (MDS/AML) whilst in first CR. The 10‐year cumulative incidence of MDS/AML of patients in first remission was 6·2% (95% confidence interval: 2·5–12·2%). In patients with newly diagnosed MCL, R‐HCVAD/MA showed sustained efficacy, with a median OS exceeding 10 years in all patients and freedom from disease recurrence of nearly 15 years in almost one‐third of the younger patients (≤65 years).
Deportation experiences and depression among U.S. citizen‐children with undocumented Mexican parents
Authors: Gulbas L. E. , Zayas L. H. , Yoon H. , Szlyk H. , Aguilar‐Gaxiola S. , Natera G. 
Published: December 2015

AbstractBackgroundThere is a critical need to document the mental health effects of immigration policies and practices on children vulnerable to parental deportation. Few studies capture the differential experiences produced by U.S. citizen‐children's encounters with immigration enforcement, much less in ways that analyse mental health outcomes alongside the psychosocial contexts within which those outcomes arise.MethodsWe explore the psychosocial dimensions of depression in U.S. citizen‐children with undocumented Mexican parents to examine differences between citizen‐children affected and not affected by parental deportation. An exploratory mixed‐method design was used to integrate a quantitative measure of depression symptoms (CDI‐2) within qualitative data collected with 48 citizen‐children aged 8 to 15 with and without experiences of parental deportation.ResultsStressors elicited by citizen‐children in the qualitative interview included an inability to communicate with friends, negative perceptions of Mexico, financial struggles, loss of supportive school networks, stressed relation with parent(s) and violence. Fifty percent of citizen‐children with probable depression – regardless of experiences with parental deportation – cited ‘stressed relation with parents,’ compared to 9% without depression. In contrast, themes of ‘loss of supportive school network’ and ‘violence’ were mentioned almost exclusively by citizen‐children with probable depression and affected by parental deportation.ConclusionsWhile citizen‐children who suffer parental deportation experience the most severe consequences associated with immigration enforcement, our findings also suggest that the burden of mental health issues extends to those children concomitantly affected by immigration enforcement policies that target their undocumented parents.
Marginal bone level changes and implant stability after loading are not influenced by baseline microstructural bone characteristics: 1‐year follow‐up
Authors: Dias Danilo Rocha , Leles Cláudio Rodrigues , Lindh Christina , Ribeiro‐Rotta Rejane Faria 
Published: December 2015

AbstractObjectiveThe aim of this study was to investigate the influence of different bone tissue characteristics of implant sites on changes in marginal bone level and implant stability over time.Material and methodsOne hundred and one implants were inserted in 41 patients. Cortical bone thickness of the alveolar ridge was measured on computed tomography (CT) images. Histomorphometric and microtomographic analyses (microCT) were performed in bone specimens obtained by using a trephine bur, at first drilling. Implant stability quotient (ISQ) measured by resonance frequency analysis (RFA) was registered at implant insertion. Implant stability quotient was measured also at the stages of uncovering, loading and at the 1‐year follow‐up, when standardized periapical radiographs were taken to measure the marginal bone level (MBL). Descriptive statistics, Spearman's rho correlation and multiple linear regression were used for data analysis (P < 0.05).ResultsComparison between groups of higher and lower values of ISQ changes and between groups of higher and lower values of MBL changes revealed no differences in histomorphometric and microtomographic parameters, according to non‐parametric comparison tests, (P > 0.05). Bivariate correlation also showed no association among these microstructural parameters and the outcomes evaluated. There was no correlation between cortical thickness and MBL changes (r = −0.029; P = 0.832) and between cortical thickness and ISQ changes (r = 0.145; P = 0.292).ConclusionMicrostructural bone characteristics of implant sites have no effect on changes in marginal bone level and implant stability as measured by RFA. Bone morphology cannot predict implant treatment success over time.
Long‐term radiographic evaluation of risk factors related to implant treatment: suggestion for alternative statistical analysis of marginal bone loss
Authors: Hasegawa Masakazu , Hotta Yasunori , Hoshino Takahiro , Ito Koji , Komatsu Shinichi , Saito Takashi 
Published: December 2015

AbstractObjectiveSecular change in marginal bone loss (MBL), which is the index adopted for implant success criteria, has often been used to evaluate risk factors. However, the need to revise these criteria has recently been indicated due to rapid developments in implant treatment. The purpose of this study was to evaluate risk factors by analyzing MBL with an alternative statistical method.Material and methodsThe analyses were performed on the outcomes of 366 patients with 1,902 implants during an average follow‐up period of 84.8 months (with a maximum follow‐up of 258 months). Instead of evaluating annual MBL, time was calculated as one of the explanatory variables because the correlation between MBL and time was small (correlation coefficient of 0.09010). Analysis of covariance (ANCOVA) was used for exploratory assessment of each factor, and multiple regression analysis was then utilized to identify risk factors. The multiple regression analysis was performed twice, once among all implants and another in which one implant per patient was randomly selected.ResultsAs a result of multiple regression analysis, smoking habits showed a significant effect on MBL. Age, sex, diabetes mellitus, implant positions, guided bone regeneration, and sinus floor elevation did not affect MBL. IMZ® implants were associated with significantly higher MBL than were ANKYLOS® and SPI® implants. There was no significant difference between Straumann® and other implants.ConclusionOur results showed that another statistical process, which eliminated the effect of time rather than comparing annual MBL, could be applied to evaluate MBL because the correlation between MBL and time was small.
Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain
Authors: Bree Dara , Moriarty Orla , Broom Daniel C. , Kelly John P. , Roche Michelle , Finn David P. 
Published: December 2015

SummaryAimsAcute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on evoked withdrawal or reflexive measures. Using a recently developed, anatomically relevant rat model of acute postoperative pain (J Pain, 16, 2015, 421), the present experiments sought to investigate the affective component of acute postoperative pain associated with inguinal hernia repair.MethodsMale Lister hooded rats underwent surgery to model Lichtenstein inguinal hernia repair (without hernia induction), or a sham procedure. Postsurgical characterization involved a modified place escape/avoidance paradigm (mPEAP), as well as home cage and open field locomotor activity monitoring. In pharmacological validation studies, rats received either morphine or carprofen prior to mPEAP testing.ResultsSurgery was associated with a significantly increased proportion of the trial duration in the light compartment of the mPEAP arena, in avoidance of the noxious stimulus, compared with sham animals. When retested in the mPEAP at day 7 postsurgery, there was no difference between sham and surgery animals for time spent in either compartment, but surgery animals displayed a persistent increase in the percentage response to noxious stimulation. Morphine and carprofen treatment in surgery animals reduced escape/avoidance behavior at discrete time points over the trial. Surgery‐induced reductions in home cage and open field locomotor activity were also observed.ConclusionThe present studies report for the first time the characterization of the affective component of acute postoperative pain using the mPEAP in a rodent model, which may facilitate development of improved understanding and treatment of postoperative pain.
Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis
Authors: Moreno‐Solís Gloria , dela Torre‐Aguilar María José , Torres‐Borrego Javier , Llorente‐Cantarero Francisco Jesus , Fernández‐Gutiérrez Fernando , Gil‐Campos Mercedes , Túnez‐Fiñana Isaac , Pérez‐Navero Juan Luis 
Published: December 2015

AbstractIntroductionOxidative stress (OS) plays a crucial role in the pathogenesis of inflammatory lung diseases.Objectives(i) We determined whether acute bronchiolitis (AB) caused by respiratory syncytial virus (RSV) induced OS; (ii) assessed whether OS biomarkers correlated with the severity of RSV‐AB; and (iii) studied whether the levels of interleukins are associated with OS biomarkers.MethodsWe performed an observational study by comparing healthy infants (Group 1) with RSV‐AB infants, classified as Group 2 (pulse oximetry (SpO2) >93%), and Group 3 (SpO2 ≤ 92%), which needed oxygen therapy. Blood samples were collected to determine the levels of lipid peroxidation (LPO) products (LPO), total glutathione (TG), oxidised glutathione (GSSG), reduced glutathione (GSH), glutathione peroxidase (GPx), interleukins (ILs) IL‐10, IL‐6, IL‐8, interferon‐gamma (IFNγ), tumour necrosis factor‐alpha (TNFα) and macrophage inflammatory proteins (MIP α and MIP β).ResultsForty‐six RSV‐AB infants (47% needed oxygen therapy) and 27 healthy infants were included. The GSH/GSSG ratio was lower in RSV‐AB infants than in Group 1 (P<0.001). GSSG and GPx were significantly higher in Group 3. GSSG predicted the need for oxygen therapy with an optimal cut‐off point of 15 µM/g for haemoglobin. The GSH/GSSG ratio negatively correlated with IL‐6 (P: 0.014), IL‐8 (P: 0.014) and IL‐10 (P: 0.033). Group 3 exhibited a direct correlation between GPx and IL‐10 levels (P: 0.024) and between LPO and MIP β (P: 0.003).ConclusionsRSV induced OS in AB. An increase in GSSG correlated with the disease severity in the infants. OS may contribute to the pathogenesis of RSV‐AB.
Emphysema is an independent risk factor for 5‐year mortality in patients with bronchiectasis
Authors: Tang Xinjun , Bi Jing , Yang Dawei , Chen Shujing , Li Zhuozhe , Chen Cuicui , Wang Guifang , Ju Mohan , Wang Jingru , Wang Yanan , Gong Ranxia , Bai Chunxue , Zhuo Hanjing , Jin Xiaoyan , Song Yuanlin 
Published: December 2015

AbstractIntroductionBronchiectasis is a common disabling respiratory disease in China. However, the literatures that focused on the long‐term prognosis and the risk factors for mortality are limited.ObjectiveThe aim of this study was to identify risk factors for 5‐year mortality in patients with bronchiectasis.MethodsA retrospective study was conducted. Patients who were newly diagnosed with bronchiectasis by thoracic conventional CT scans from January 2003 to March 2008 were assessed. Baseline characteristics, symptoms, radiographic extent, pulmonary function tests data and comorbidities were recorded through chart review. The vital status of the patients was obtained by telephone contact and record of hospital admission. Multivariate cox regression analysis was used to determine the independent risk factors for 5‐year mortality.ResultsEighty‐nine patients newly diagnosed with bronchiectasis were included in our cohort. The mean age of the cohort was 55.29 ± 16.15 and 49.4% of the patients were female. At the end of the study, 12 patients (13.5%) died and the mean survival time was 57.05 ± 1.09 months. Multivariate analysis revealed that long‐term mortality was significantly associated with emphysema (HR, 5.62; 95% confidence interval [CI], 1.35–23.46; P = 0.02) and radiographic extent (HR, 1.62; 95% CI, 1.02–2.58; P = 0.04).ConclusionThe main finding of our study was that emphysema might be a risk factor for mortality in patients with bronchiectasis.