bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing sexual function and dysfunction in Turkish women undergoing surgical breast cancer treatment
Authors: Öztürk Didem , Akyolcu Neriman 
Published: January 2016

AbstractAimThe purpose of this study was to determine whether there are differences between Turkish women undergoing postmastectomy breast reconstruction and those undergoing breast‐conserving surgery (BCS) or mastectomy alone.MethodsThe sample of the study, which was designed as a descriptive and regressional one, consisted of a total of 100 female patients, 33 undergoing BCS, 34 undergoing postmastectomy breast reconstruction, and 33 undergoing mastectomy for breast cancer, between 2008 and 2012. Data were collected through an individual characteristics form and Female Sexual Function Index (FSFI).ResultsThe comparison of the type of surgical procedure and the mean FSFI scores for the subscales of desire, arousal, orgasm, satisfaction, and pain, and the mean total FSFI scores revealed a statistically significant difference in favor of postmastectomy breast reconstruction and BCS (P < 0.05). When the authors evaluated the effects of age and surgical procedure type from the risk factors associated with total FSFI score classification by the logistic regression analysis, variations of age and surgical procedure type were found significant in the authors' model (P < 0.05). Age and surgical procedure type were independent risk factors effective on the total FSFI score of less than 26.55.ConclusionIn this study, based on the mean total FSFI scores of women, it was concluded that postmastectomy breast reconstruction had positive effects on sexual lives of Turkish women with breast cancer, that more satisfactory outcomes were obtained in those undergoing BCS, that mastectomy had negative effects on sexual function, thus leading to sexual dysfunction, and that age was negatively associated with sexual functions.
Factors influencing nurses' attitudes and intentions toward medication administration error reporting
Authors: Hung Chang‐Chiao , Lee Bih‐O. , Liang Hwey‐Fang , Chu Tsui‐Ping 
Published: January 2016

AbstractAimThe aims of this study were to explore the factors that influence nurses' attitudes and intentions toward medication administration error (MAE) reporting.MethodsThe theory of planned behavior was used as the framework for this study. A cross‐sectional design was used, and data were obtained from self‐administered questionnaires. A total of 596 staff nurses who worked in a regional hospital for at least 3 months were invited to participate in this study. The researchers used exploratory factor analysis and confirmatory factor analysis to test the psychometric properties of each measurement scale. The 1 week data collection period was between September and November 2013. Descriptive statistics were used to examine the demographic and job characteristics of the participants and multiple linear regression was used to test the hypotheses.ResultsOf the 596 nurses invited to participate, 548 (92%) completed and returned a valid questionnaire. The findings indicated that altruism, and nurse managers' and co‐workers' attitudes are predictors for nurses' attitudes toward MAE reporting, and nurses' attitudes and co‐workers' attitudes affect nurses' intention to report MAE. No connection was found between report control and nurses' intentions toward MAE reporting.ConclusionThe findings reflected that altruism, and nurse managers' and co‐workers' attitude, and nurses' attitudes toward MAE reporting are predictors of nurses' intentions toward MAE reporting. The authors strongly recommended the healthcare system to institute an open communication and learning culture.
Facial and vestibular neuropathy of unknown origin in 16 dogs
Authors: Jeandel A. , Thibaud J. L. , Blot S. 
Published: January 2016

OBJECTIVESThe aim of this study was to describe the signalment, clinical presentation, diagnostic findings and long‐term follow‐up in dogs with concomitant facial and vestibular neuropathy of unknown origin.METHODSAppropriate cases were located through medical record searches. Inclusion criteria comprised dogs that had: clinical signs of facial paralysis with concomitant peripheral vestibular syndrome, thyroid function tests, no abnormalities on magnetic resonance imaging of the brain and tympanic bullae, and cerebrospinal fluid analysis.RESULTSSixteen dogs met the inclusion criteria. Facial paralysis had acute onset (<24 hours) in all dogs, thyroid function was within normal limits. There was albuminocytologic dissociation in cerebrospinal fluid of 69% of the dogs. There was complete resolution of clinical signs in 31% of the dogs but 38% showed long‐term vestibular deficits, 46% developed hemifacial contracture, 15% had permanent facial paralysis and 15% relapsed.CLINICAL SIGNIFICANCEFacial and vestibular neuropathy of unknown origin shares similarities with idiopathic facial paralysis. The prognosis for return of normal facial and vestibular function is guarded and there may be relapse after recovery.
Entecavir plus tenofovir combination therapy in patients with multidrug‐resistant chronic hepatitis B: results of a multicentre, prospective study
Authors: Park Jun Yong , Kim Chang Wook , Bae Si Hyun , Jung Kyu Sik , Kim Hee Yeon , Yoon Seung Kew , Han Kwang‐Hyub , Ahn Sang Hoon 
Published: January 2016

AbstractBackground & AimsSequential therapy posed a high risk of emergence of multidrug resistance and presented a management issue in chronic hepatitis B (CHB) treatment. We evaluated the antiviral efficacy and safety of entecavir (ETV) plus tenofovir (TDF) combination therapy in multidrug‐resistant (MDR) CHB patients.MethodsIn this prospective, multicentre study, MDR CHB patients, defined as measurable serum HBV DNA (≥60 IU/ml) while on any rescue treatment regimen for at least 24 weeks and the presence of documented prior genotypic resistance to both nucleoside analogue(s) and nucleotide analogue, were treated with ETV 1.0 mg and TDF 300 mg combination therapy for 48 weeks.ResultsA total of 64 eligible patients who had previously failed to a median three lines of antiviral therapy (range, 2–6) were included. At baseline, median age was 47.0 years, 89.1% were HBeAg(+), and median HBV DNA was 4.24 (range, 2.11–6.73) log10 IU/ml. By week 4, 12, 24 and 48, 15/64 (23.4%), 36/64 (56.3%), 43/64 (67.2%) and 55/64 (85.9%) patients achieved a HBV DNA <60 IU/ml respectively. The mean reduction of HBV DNA from baseline to 4 and 48 weeks was 1.23 log10 IU/ml and 2.38 log10 IU/ml respectively. Although five patients experienced virological breakthrough, all were transient and no resistant mutation to TDF or novel mutation was detected in any patients.ConclusionsIn difficult‐to‐treat MDR CHB patients with a high exposure to multiple antiviral drugs, ETV plus TDF combination therapy can provide a very high rate of viral suppression through 48 weeks of treatment.
Multiple mortality events in bats: a global review
Authors: O'Shea Thomas J. , Cryan Paul M. , Hayman David T.S. , Plowright Raina K. , Streicker Daniel G. 
Published: January 2016

Abstract
Despite conservation concerns for many species of bats, factors causing mortality in bats have not been reviewed since 1970. Here, we review and qualitatively describe trends in the occurrence and apparent causes of multiple mortality events (MMEs) in bats around the world.
We compiled a database of MMEs, defined as cases in which ≥ 10 dead bats were counted or estimated at a specific location within a maximum timescale of a year, and more typically within a few days or a season. We tabulated 1180 MMEs within nine categories.
Prior to 2000, intentional killing by humans caused the greatest proportion of MMEs in bats. In North America and Europe, people typically killed bats because they were perceived as nuisances. Intentional killing occurred in South America for vampire bat control, in Asia and Australia for fruit depredation control, and in Africa and Asia for human food. Biotic factors, accidents, and natural abiotic factors were also important historically. Chemical contaminants were confirmed causes of MMEs in North America, Europe, and in islands. Viral and bacterial diseases ranked low as causes of MMEs in bats.
Two factors led to a major shift in causes of MMEs in bats at around 2000: the global increase of industrial wind‐power facilities and the outbreak of white‐nose syndrome in North America. Collisions with wind turbines and white‐nose syndrome are now the leading causes of reported MMEs in bats.
Collectively, over half of all reported MMEs were of anthropogenic origin. The documented occurrence of MMEs in bats due to abiotic factors such as intense storms, flooding, heat waves, and drought is likely to increase in the future with climate change. Coupled with the chronic threats of roosting and foraging habitat loss, increasing mortality through MMEs is unlikely to be compensated for, given the need for high survival in the dynamics of bat populations.
Gene expression regulatory networks in Trypanosoma brucei: insights into the role of the mRNA‐binding proteome
Authors: Lueong Smiths , Merce Clementine , Fischer Bernd , Hoheisel Jörg D. , Erben Esteban D. 
Published: January 2016

SummaryControl of gene expression at the post‐transcriptional level is essential in all organisms, and RNA‐binding proteins play critical roles from mRNA synthesis to decay. To fully understand this process, it is necessary to identify the complete set of RNA‐binding proteins and the functional consequences of the protein‐mRNA interactions. Here, we provide an overview of the proteins that bind to mRNAs and their functions in the pathogenic bloodstream form of Trypanosoma brucei. We describe the production of a small collection of open‐reading frames encoding proteins potentially involved in mRNA metabolism. With this ORFeome collection, we used tethering to screen for proteins that play a role in post‐transcriptional control. A yeast two‐hybrid screen showed that several of the discovered repressors interact with components of the CAF1/NOT1 deadenylation complex. To identify the RNA‐binding proteins, we obtained the mRNA‐bound proteome. We identified 155 high‐confidence candidates, including many not previously annotated as RNA‐binding proteins. Twenty seven of these proteins affected reporter expression in the tethering screen. Our study provides novel insights into the potential trypanosome mRNPs composition, architecture and function.
Theology and “What Matters Most”: Distinctions, Connections and Confusions
Authors: Endean Philip 
Published: January 2016

AbstractThis opening paper seeks to situate discussions about the academic status of “softer”, more practical disciplines within wider contexts. The most important and most distinctively theological of these is conditioned by the particular claims of Christian tradition about the saving revelation of a God who yet remains unseen and transcendent. Also relevant are ethical and political questions about the nature of education, and speculative questions about theoretical and practical reason.
“Praying in the Holy Spirit” Spirituality and Pneumatology
Authors: Vetö Etienne 
Published: January 2016

AbstractWhile “praying in the Spirit” may evoke “charismatic” prayer, this paper argues that from a scriptural point of view it defines all Christian prayer as having the Holy Spirit as main subject, who leads us to pray and prays in us, by showing us to whom, how and for what we should pray. This has implications for spirituality and pneumatology. On the one hand, prayer is to be understood as much more than the extension of our human desire towards God: it means entering into the divine will, the divine life, and the relations between Father, Son and Spirit – and relating to each in a different way. This actually helps to catch the essence of charismatic prayer as well, which is precisely letting the Spirit pray in us: charisms and “enthusiasm” are an expression of this and are in their right place when they are referred to it. On the other hand, the Holy Spirit manifests itself as a unique type of divine person, which acts and speaks in and through others. The paper contends that this economical specificity needs to be re-elaborated on the level of the immanent Trinity in a novel way: the divine names of Ruah and Pneuma allow us to conceive the Spirit as the most intimate Breath which the Father breathes (spires) into the depths of the Son.
‘Spiritual But Nor Religious’ – Some Final Reflections
Authors: Simmonds Gemma 
Published: January 2016

AbstractIn the discourse of a number of theologians there is a perceived gap between spirituality and ‘theology proper’. This gap would not have been perceived or understood by Aquinas, Augustine or others of the long tradition of theological enquiry, since they saw union with God as the highest fruit of theological thinking. There is another gap today between the term ‘spirituality’ used in a loose and decontextualized fashion by the Mind, Body, Spirit industry and those for whom its study is part of mystical theology and its practice part of the church's mystagogia. The fact that many otherwise orthodox believers, as well as those alienated from regular church belief and practice, turn to more esoteric spiritual paths may be a sign that a return to a better-informed and theologically grounded knowledge of the mystical tradition is long overdue.
Inactivation by Pulsed Light of Bacillus subtilis Spores with Impaired Protection Factors
Authors: Esbelin Julia , Malléa Sabine , Clair Gérémy , Carlin Frédéric 
Published: January 2016

AbstractThe resistance to pulsed light (PL) of spores of Bacillus subtilis strain 168 and of strains with mutations increasing sensitivity to UV‐C or affecting spore structure was evaluated and compared to resistance to continuous UV‐C and moist heat, in order to reveal original mechanisms of inactivation by PL. Spores of B. subtilis strain 168 (1A1) and eight mutant strains (sspA, sspB, sspAB, cotA, gerE, cotE, uvrA and recA) were exposed to PL (up to 1.77 J cm−2), continuous UV‐C (up to 147 mJ cm−2) and moist heat at 90°C. Spores of the strains lacking proteins linked to coat formation or structure (cotA, gerE and cotE) were markedly more sensitive to PL than 1A1, while their sensitivity to continuous UV‐C or to moist heat was similar to the one of strain 1A1. Coat proteins had a major contribution to the resistance of B. subtilis spores to PL irradiation characterized by short‐time and high‐energy pulses of white light in the wavelengths 200–1100 nm. In contrast the role of coat proteins to UV‐C or to moist heat resistance was marginal or null.
Detection of cerebral amyloid angiopathy by 3‐T magnetic resonance imaging and amyloid positron emission tomography in a patient with subcortical ischaemic vascular dementia
Authors: Kida Hirotaka , Satoh Masayuki , Ii Yuichiro , Fukuyama Hidenao , Maeda Masayuki , Tomimoto Hidekazu 
Published: January 2016

AbstractThe patient was an 81‐year‐old man who had been treated for hypertension for several decades. In 2012, he developed gait disturbance and mild amnesia. One year later, his gait disturbance worsened, and he developed urinary incontinence. Conventional brain magnetic resonance imaging using T
2‐weighted images and fluid‐attenuated inversion recovery showed multiple lacunar infarctions. These findings fulfilled the diagnostic criteria for subcortical ischaemic vascular dementia. However, susceptibility weighted imaging showed multiple lobar microbleeds in the bilateral occipitoparietal lobes, and double inversion recovery and 3‐D fluid‐attenuated inversion recovery images on 3‐T magnetic resonance imaging revealed cortical microinfarctions in the left parietal‐temporo‐occipito region. Pittsburgh compound B‐positron emission tomography revealed diffuse uptake in the cerebral cortex. Therefore, we diagnosed the patient with subcortical ischaemic vascular dementia associated with Alzheimer's disease. The use of the double inversion recovery and susceptibility weighted imaging on 3‐T magnetic resonance imaging may be a supplemental strategy for diagnosing cerebral amyloid angiopathy, which is closely associated with Alzheimer's disease.
Powerful unconfined turbidity current captured by cabled observatory on the Fraser River delta slope, British Columbia, Canada
Authors: Lintern D. Gwyn , Hill Philip R. , Stacey Cooper 
Published: January 2016

AbstractTurbidity currents are one of the main sediment transport processes on Earth, yet are notoriously difficult to monitor directly. This article presents the first direct and high bandwidth observation of a turbidity current using a cabled sea floor observatory. On 5 June 2012, a platform on Ocean Networks Canada, located in 107 m of water on the Fraser River delta slope, was displaced downslope and severed from its data cable. The platform weighed ca 1000 kg in water. The event took place during high river discharge, high tides and rapid sediment accumulation on adjacent upslope areas of the sea floor. Data recorded as it tumbled downslope allow a reconstruction of the flow, which is inferred to have been an unconfined turbidity current. Lines of evidence indicate that the flow came in as a bed hugging wedge, and built up to between 1 m and 4 m in height as the head passed through. Comparison with laboratory data suggest that the flow was initially supercritical. While the adjacent slope offset to the north clearly exhibits change over an annual resurvey period, the bathymetry directly at the event location show no resolvable change over a period from seven months before the event to one month after. Sediment cores collected after the event were pervasively biototurbated and they contain no obvious deposit connected with this event. The remarkable aspects of this research follow. The flow was powerful enough to carry a 1 tonne platform and sever a heavily armoured cable. The current occurred on the unchannelized open slope. This powerful event failed to cause discernible seabed elevation change. The flow was triggered by tidal conditions. The event was detected by a purpose‐designed cabled observatory, thus providing high bandwidth data and also alerting researchers in real time to mount follow‐on investigations.
An advocacy experience for medical students
Authors: Baribeau Danielle , Ramji Nasreen , Slater Morgan , Weyman Karen 
Published: January 2016

SummaryBackgroundPromoting advocacy and social responsibility is a requirement of medical education. This article describes a brief clinical educational initiative to foster advocacy amongst medical students, and explores student attitudes towards homelessness.MethodsA compulsory clinical experience in homeless health was integrated into the family medicine clerkship curriculum for a subset (n = 30) of all third‐year medical students (n = 254) at the University of Toronto in 2012/13. This programme consisted of four half‐days, in which students provided primary care within a shelter setting under supervision from a physician. The experience was paired with a supportive and reflective debriefing session, and feedback was collected from participating students. Surveys on attitudes towards homelessness were also administered to all third‐year students before and after their rotation in family medicine.Students provided primary care within a shelter setting under supervision from a physicianResultsStudent feedback indicated that the programme was very well received; however, some students described feeling overwhelmed at times when working with this vulnerable population. On attitude surveys, female sex, age, earlier month of survey administration and interest in certain specialties was associated with more positive attitudes towards homelessness.DiscussionA brief clinical experience outside of a traditional health care setting in which students are exposed to the day‐to‐day reality of advocating for vulnerable populations can meaningfully contribute to a comprehensive advocacy curriculum. We suggest this programme could be feasibility adapted to other settings and populations. The importance of supportive and reflective mentorship and diverse clinical settings are highlighted.
Calculation Model for Internal Gear Skiving With a Pinion-Type Cutter Having Pitch Deviation and a Run-Out
Authors: Tachikawa Tomokazu , Kurita Nobuaki , Nakamura Morimasa , Iba Daisuke , Moriwaki Ichiro 
Published: January 2016

As the emerging economies expand, demand for low cost production of internal gears has been increasing. And skiving is in focus as a potential method than can meet this demand.
Skiving was invented in 1910, since then, mechanical machine has been developed to NC machine and cutter design technologies have developed dramatically. As a result, several machine and tool manufacturer started to release their skiving machine and skiving cutter as well.
Furthermore, many studies on the kinematics have been conducted both in research institutions and private companies. However, most of these studies are subject to understanding the cutting mechanisms as a basic research and establishing cutter design methods.
For further improvement and boost widespread application of the process, optimization of the manufacturing process is an issue. Particularly, the effects of cutter accuracy and cutter set up deviations on the skived gear are important to ensure reliability of the process. Unfortunately, few studies on those effects can be found.
In this paper, geometrical model that can predict the effect of pitch deviation and of run out of a cutter on a skived gear is proposed. Experiments were also carried out to verify the validity of the model, and the results were in good agreement with the simulated ones.
Research on Surrogate Model Based on Local Radial Point Interpolation Method
Authors: Wang Rongqiao , Mao Jianxing , Hu Dianyin 
Published: January 2016

In order to increase the accuracy of surrogate models in structural reliability analysis, we put forward a kind of surrogate model based on local radial point interpolation method (LRPIM). Three kinds of radial basis function (RBF) are employed for the shape function construction to form different kinds of LRPIM model.
In order to illustrate the approximating ability of each surrogate model, we build up a nonlinear function model and carry out a numerical experiment on gas turbine disk’s estimated life-span. Compared with polynomial model, Chebyshev orthogonal polynomial model, Kriging model and RBF neural network model, LRPIM model has a demonstrable difference in terms of accuracy. For different polynomial basis order with constant sampling nodes amount, we conclude that fluctuant accuracy can be described by the balance between the describing improvement brought by polynomial basis order increase and the local impairment brought by support domain expansion. For sampling nodes amount with constant polynomial basis order, we conclude that accuracy of LRPIM model improves when sampling nodes amount increases.
In order to illustrate the potential in reliability analysis, we apply the best performing LRPIM model to a set of widely used test problems, which certifies the accuracy and robustness of this kind of surrogate model.
In a word, LRPIM model is one of the most promising surrogate models compared with other models on nonlinear approximating problems and reliability analysis.