bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'effacement diffus, métier numérique associant les consommateurs à la transition écologique
Authors: Bivas Pierre 
Published: September 2024

La France a vu naître un nouveau métier mobilisant le numérique pour accompagner la transition énergétique : l’effacement diffus. Il s’agit d’installer des boîtiers chez les consommateurs volontaires pour piloter à distance des millions d’appareils électriques en temps réel et ainsi pour chacun, gratuitement, réaliser des économies d’énergie (jusqu’à - 15 %), et tous ensemble participer au pilotage et à la fiabilisation du système électrique. Techniquement, effacer des consommations évite de produire et d’acheminer l’électricité. Économiquement, cela permet de réduire les coûts pour tous. Et pour le climat, cela évite des émissions de CO 2 et facilite l’intégration des renouvelables. Tous les pays développés ouvrent donc leur marché à l’effacement comme une alternative à la production. Mais cette concurrence venue des consommateurs, souhaitée par le politique, n’est pas du goût des producteurs traditionnels qui voudraient parfois la freiner – le temps de s’adapter ?
Coévolution des systèmes électriques et informatiques du Groupe EDF depuis vingt ans
Authors: Niebel Vincent 
Published: September 2024

Depuis vingt ans, le système électrique opéré par le Groupe EDF est confronté à de multiples défis. L’ouverture à la concurrence des marchés européens de l’énergie, le développement des énergies renouvelables et la transition énergétique vers une électrification massive des usages ont bouleversé ses équilibres économiques, ses infrastructures techniques et son environnement réglementaire. Le système d’information, ayant connu des évolutions tout aussi spectaculaires, a accompagné ces mutations des activités de l’énergie : production, optimisation, distribution et commercialisation. La numérisation des services a progressivement rapproché systèmes énergétiques et informatiques, au point de considérer aujourd’hui, et demain, ces deux domaines comme un système convergé : un réseau d’énergie et de services intelligents, s’appuyant sur les données et les technologies actuelles, ou à venir (moyens de production et de stockage d’énergie, réseaux, IoT, IA, 5G, quantique, cyber).
« La connexion réseau a été perdue » Essai sur la représentation et l’imaginaire des mondes virtuels
Authors: Dufrêne Thierry 
Published: September 2024

En 1940, Adolfo Bioy Casarès concevait dans L’Invention de Morel (1940) le plus convaincant des « mondes virtuels » de notre ère contemporaine. Au cours des années 1960-1970, à la rencontre de l’aventure spatiale lunaire, du développement des mass media , des utopies de la jeunesse et du psychédélisme, la science-fiction – Wells, Asimov et K. Dick – imagine à son tour des « mondes virtuels ». Dans la décennie suivante, après l’hyperréalisme dans les arts visuels, la simulation et la séduction du faux ( fake ) passionnent les chercheurs et les artistes tout autant que les ingénieurs. Avec Internet, les « mondes virtuels » sont devenus la norme des interfaces homme-machine et des réseaux informatiques. L’interactivité (multi-joueurs) et la simulation offrent à ces mondes ce qu’Étienne Souriau appelait en 1943 une « possibilité absolue » : un imaginaire de la connexion est né. Cet article pose la question d’un nouveau pacte d’extension anthropologique où l’humain s’émule à son double et à ceux du monde. Mais lorsque les dispositifs immersifs et les interfaces (lunettes 3D et gants haptiques) seront remplacés par des greffes à même le corps humain, comme l’augure le transhumanisme, de quoi sera porteuse la rencontre de l’actuel et du virtuel ?
Qui sont les acteurs du métavers ?
Authors: Jolie Paul , Caquot Emmanuel 
Published: September 2024

L’idée d’un monde virtuel s’est matérialisée dès 1997 en France, où Canal+mulimédia ouvre Le Deuxième Monde, qui permet aux joueurs d’évoluer, par leur avatar, dans une reconstitution de Paris en 3D, formant ainsi une communauté virtuelle dont les membres se surnomment « les Bimondiens ». Précurseur du métavers, il est toutefois fermé en 2001 et c’est en 2003 Second Life de Linden Lab, qui connaît un premier succès mondial. L’idée connaît un renouveau d’intérêt à plus grande échelle en 2021 avec les annonces de Marc Zuckerberg. Si l’intérêt médiatique s’est depuis essouflé avec les difficultés rencontrées, il n’en demeure pas moins que le sujet reste très actif en termes d’investissements aux États-Unis et dans au moins quatre pays d’Asie, avec de nombreux groupes qui développent plateformes et applications. L’Europe a surtout une approche réglementaire et défensive, mais dispose néanmoins d’atouts, y compris en France, et d’ambitions pouvant reposer sur Dassault Systèmes, Ubisoft, Atos, les opérateurs de télécommunication et un tissu de start-up.
Ranking the Orthopedic Procedures With the Highest Morbidity and Mortality
Authors: Ernst Brady S. , Kiritsis Nicholas R. , Wyatt Phillip B. , Reiter Charles R. , O'Neill Conor N. , Satalich James R. , Vap Alexander R. 
Published: September 2024

Background
Musculoskeletal conditions currently affect more than one-third of the US population and orthopedic procedures play a pivotal role in managing them. Like any invasive intervention, these carry a wide spectrum of risk, necessitating a comprehensive understanding of the associated morbidity and mortality. This study sought to provide a global perspective of the risks and complications associated with these procedures to establish an easy to understand risk stratification tool for both patients and providers.

Materials and Methods

Current Procedural Terminology
codes associated with orthopedic surgery were identified in the American College of Surgeons National Surgical Quality Improvement Program database from 2018 to 2020. Each code was associated with its rate of 30-day mortality as well as any adverse event (AAE) and then ranked for descriptive analysis.

Results
In total, there were 698,549 patients who underwent orthopedic procedures associated with 94 CPT codes with at least 1 morbidity event and 144 CPT codes with at least 1 AAE. The CPT code associated with the highest mortality was 27590 or above knee amputation. The CPT code associated with the highest rate of AAE was 27507 or open treatment of femoral shaft fracture with plate and screws.

Conclusion

This is the first study to compare the rates of morbidity and mortality in all patients with orthopedic procedures. There was a strong bias toward increased risk associated with lower extremity surgery and surgery most often performed in the geriatric population. [
Orthopedics
. 2025;48(1):e40–e44.]
Challenges in the Development of NK-92 Cells as an Effective Universal Off-the-Shelf Cellular Therapeutic
Authors: Niu Zhiyuan , Wang Mengjun , Yan Yangchun , Jin Xinru , Ning Linwei , Xu Bingqian , Wang Yanfeng , Hao Yuekai , Luo Zhixia , Guo Changjiang , Zhi Lingtong , Zhu Wuling 
Published: September 2024

Abstract
The human-derived NK-92 cell–based CAR-NK therapy exhibits inconsistency with overall suboptimal efficacy and rapid in vivo clearance of CAR-NK92 cells in cancer patients. Analysis indicates that although pre-existing IgM in healthy individuals (n = 10) strongly recognizes both NK-92 and CAR-NK92 cells, IgG and IgE do not. However, only a subset of cancer patients (3/8) exhibit strong IgM recognition of these cells, with some (2/8) showing pre-existing IgG recognition. These results suggest a natural immunoreactivity between NK-92 and CAR-NK92 cells and pre-existing human Abs. Furthermore, the therapy’s immunogenicity is evidenced by enhanced IgG and IgM recognition postinfusion of CAR-NK92 cells. We also confirmed that healthy plasma’s cytotoxicity toward these cells is reduced by complement inhibitors, suggesting that Abs may facilitate the rapid clearance of CAR-NK92 cells through complement-dependent cytotoxicity. Given that NK-92 cells lack known receptors for IgG and IgM, identifying and modifying the recognition targets for these Abs on NK-92 and CAR-NK92 cells may improve clinical outcomes. Moreover, we discovered that the 72nd amino acid of the NKG2D receptor on NK-92 cells is alanine. Previous studies have demonstrated polymorphism at the 72nd amino acid of the NKG2D on human NK cells, with NKG2D72Thr exhibiting a superior activation effect on NK cells compared with NKG2D72Ala. We confirmed this conclusion also applies to NK-92 cells by in vitro cytotoxicity experiments. Therefore, reducing the immunoreactivity and immunogenicity of CAR-NK92 and directly switching NK-92 bearing NKG2D72Ala to NKG2D72Thr represent pressing challenges in realizing NK-92 cells as qualified universal off-the-shelf cellular therapeutics.
Understanding wise leadership: Employees’ perspective in Oman’s government sector
Authors: Awashreh Raed A. , Hamid Abdelsalam A. 
Published: September 2024

Orientation: Success is a common goal in both personal and professional life, and wise leadership is key to achieving it. Effective leadership guides and motivates teams, driving them toward success and excellence.Research purpose: This study examines wise leadership in Oman’s government sector, using Hassi and Storti’s theoretical frameworks. It explores dimensions such as Intellectual Shrewdness, Spurring Action, Moral Conduct, and Cultivating Humility to improve employee awareness and perception.Motivation for the study: To assess wise leadership qualities across different dimensions and demographic groups to identify strengths and areas for improvement in leadership practices.Research approach/design and method: A descriptive method was employed, and a questionnaire was used as a data gathering tool. The data were analysed by several techniques including T-tests, ANOVA and descriptive statistics. Data were anonymously collected from 300 respondents across the Ministry of Labour, Ministry of Information and Taxation Authority, representing diverse demographic profiles and organisational ranks.Main findings: The findings highlight that practical wisdom is vital for organisational resilience, effective communication, and societal well-being in complex governance. While there is broad agreement on key leadership traits, minor discrepancies suggest challenges in applying theoretical ideals, especially concerning vulnerability and humility.Practical/managerial implications: Providing a detailed look at employees’ views on wise leadership and the impact of personal characteristics on these perceptions.Contribution/value-add: Provides a comprehensive view of employees’ perceptions of wise leadership and how personal characteristics influence these perceptions.
Insulinoma in Patients with Diabetes- A Systematic Review of Previously Reported Cases
Authors: Chatterjee Subhankar , Bhattacharjee Rana , Ghosh Ritwik , Chakraborty Partha P. , Sinha Anirban , Maiti Animesh 
Published: September 2024

Abstract

Introduction:
Paradoxical co-existence of insulinoma and diabetes is extremely rare. Although a few case reports addressed this association, a comprehensive study elucidating this relationship has been lacking. We performed a systematic review of published cases of insulinoma in diabetes.

Methods:
We conducted a literature search using PubMed and Google Scholar, employing various combinations of the following terms: ‘insulinoma’, ‘diabetes’, ‘nesidioblastosis’, ‘endogenous hyperinsulinism’, ‘hypoglycaemia’, and ‘hyperglycaemia’ (from January 1900 to January 30, 2024). Exclusion criteria included non-English publications, duplicate articles, reports lacking sufficient data, cases of endogenous hyperinsulinemic hypoglycaemia other than insulinoma, and inaccessible articles. Statistical analysis was performed using appropriate methods.

Results:
Sixty patients were considered for the final analysis. Mean age was 61 ± 15 years (range: 17–96 years) with a slight female preponderance; 88.3% had type-2 diabetes with a median duration of 8 years. The median delay in diagnosis of insulinoma was 6 months. Median blood glucose varied from 30.5 mg/dL to 235 mg/dL, with a mean HbA1c of 5.6 ± 1.3% (range: 2.9%–8.2%). Critical sampling data were available in 75% of cases. The median size of the insulinoma was 2 cm. Furthermore, 5.2% of insulinomas were extra-pancreatic. Among pancreatic insulinomas, 14.5% were multi-focal. One-third of cases were malignant. Surgical resection was done in 70.9% of cases, while 40% received drug therapy and 12.7% received both, with 20.7% overall mortality. Malignant insulinoma (P = 0.007), micro-angiopathic (P = 0.018) and macro-angiopathic complications (P = 0.039), and other co-morbidities (P = 0.009) were associated with unfavourable prognosis, while being overweight and obese (P = 0.020) at presentation was associated with favourable prognosis.

Conclusion:
This first systematic review provides insights into the uniqueness of insulinoma in diabetes.
Effects of Modified Atkins Diet on Neurocognitive Function in Refractory Epilepsy
Authors: Qamar Muhammad M. , Basharat Ayesha , Basharat Shahnai , Kiran Qurba 
Published: September 2024

ABSTRACT

Background:
Diet therapy is an effective intervention to manage a wide range of seizures and has a wide range of acceptance. This anti-epileptic effect of the ketogenic diet and fasting has been linked with increased ketone levels and may lead to hypoproteinemia or growth issues. The modified Atkin diet is safe and can be taken without fluid or caloric restriction. Furthermore, the patient can use unlimited protein and fat.

Objective:
The study finds out the effects of the modified Atkins diet on fatigue and cognitive functional status in refractory epilepsy.

Materials and Methods:
Twenty-seven subjects (17 males, 10 females) suffering from refractory epilepsy were recruited. The mean age range was 09–15 years. The modified Atkins diet prescribed by diet specialists was introduced. The Visual Analog Scale was used for measuring fatigue levels, and the Quality of Life in Childhood Epilepsy was used to examine the effects on life quality in epileptic patients after 16 weeks.

Results:
The subject’s mean age was 11.7 ± 2.02 years. They had epilepsy for about 7.8 ± 3.1 years. The seizer frequency was about 2–5 days per week. The muscle fatigue level, seizer frequency, and quality of life were improved after 16 weeks (<0.05).

Conclusion:
The modified Atkins diet exhibits some encouraging results in refractory epilepsy patients.
The effectiveness of vedolizumab in advanced therapy-experienced ulcerative colitis patients: Real world data from the Inflammatory Bowel Disease of the Middle East (IBD-ME) Registry group
Authors: Azzam Nahla , Alharbi Othman , Altuwaijri Mansour , Alruthia Yazed , Alfarhan Heba , Alshankiti Suliman , Nafisah Faris , Ajlan Qusay , Aljebreen Abdulrahman , Almadi Majid , Mosli Mahmoud H. 
Published: September 2024

Abstract

Background:
Vedolizumab is an approved ulcerative colitis (UC) treatment. Multiple large randomized clinical trials have demonstrated the drug’s efficacy and safety. However, real-world data from Middle Eastern countries are spare. The study aims to evaluate the clinical efficacy of vedolizumab (VDZ) therapy in advanced therapy experienced UC patients.

Methods:
A retrospective electronic chart review of a cohort study of 153 moderately to severely active UC patients who failed or were intolerant to TNF antagonists and received vedolizumab from two large tertiary care centers was performed. Rates of clinical response and remission were retrospectively evaluated at 3,6, and 12 months post VDZ therapy using Patient Simple Clinical Colitis Activity Index (P-SCCAI); clinical response was defined as a decrease in P-SCCAI ≥3, and clinical remission was defined as a P-SCCAI score of ≤3 points. Logistic regression analysis was used to identify predictors of response to vedolizumab.

Results:
A total of 153 UC patients had sufficient data for analysis. Clinical remission rates were 61.9% for patients on vedolizumab every 8 weeks and 89.3% for those receiving every 4 (Q4) weeks dosing. A significant reduction in CRP and improvement of albumin post vedolizumab treatment were observed, and corticosteroids were stopped in most patients. In a multiple logistic regression analysis, several factors were found to influence the clinical effectiveness of VDZ in inducing remission. Female gender was associated with a higher likelihood of remission [OR =3.09, 95% CI = (1.05–9.13), P = 0.04]. Conversely, a greater number of biologics used prior to VDZ treatment was associated with a lower likelihood of remission [OR =0.418, 95% CI = (0.203–0.859), P = 0.017]. Patients with extensive disease (E3) had an increased likelihood of remission [OR =3.81, 95% CI = (1.32–10.97), P = 0.0129]. Additionally, a VDZ dosing frequency of Q4 weeks was associated with a significantly higher likelihood of remission [OR =6.08, 95% CI = (1.73–21.39), P = 0.0049]. No significant safety signals were reported.

Conclusions:
In this current real-world study, vedolizumab effectively achieved clinical response and remission in most advanced therapy experienced UC patients treated for up to 12 months. Future studies with larger sample sizes and more robust study designs should be conducted to further validate the results of this study.
The category $\Theta_{2}$, derived modifications, and deformation theory of monoidal categories
Authors: Panero Piergiorgio , Shoikhet Boris 
Published: September 2024

A complex

C^{\bullet}(C,D)(F,G)(\eta,\theta)

, generalising the Davydov–Yetter complex of a monoidal category (Davydov (1998) and Yetter (1998)), is constructed. Here,

C,D

are

\Bbbk

-linear (corresp., dg) bicategories,

F,G\colon C\to D

are

\Bbbk

-linear (corresp., dg) strong functors, and

\eta,\theta\colon F\Rightarrow G

are strong natural transformations. Morally, it is a complex of “derived modifications”

\eta\Rrightarrow\theta

; likewise for the case of dg categories, one has the complex of “derived natural transformations”

F\Rightarrow G

, given by the Hochschild cochain complex of

C

with coefficients in

C

-bimodule

D(F-,G=)

.The complex

C^{\bullet}(C,D)(F,G)(\eta,\theta)

naturally arises from a 2-cocellular dg vector space

A(C,D)(F,G)(\eta,\theta)\colon\Theta_{2}\to C^{\bullet}(\Bbbk)

, as its

\Theta_{2}

-totalisation (here,

\Theta_{2}

is the category dual to the category of Joyal 2-disks (Joyal (1997))).It is shown that for a

\Bbbk

-linear monoidal category

C

, the third cohomology vector space

H^{3}(C^{\bullet}(C,C)(\mathrm{Id},\mathrm{Id})(\mathrm{id},\mathrm{id}))

is isomorphic to the vector space of the outer (modulo twists) infinitesimal deformations of the

\Bbbk

-linear monoidal category which we call the
full
deformations. It means that the following data is to be deformed: (a) the underlying dg category structure, (b) the monoidal product on morphisms (the monoidal product on objects is a set-theoretical datum and is maintained under the deformation), and (c) the associator. The data (a), (b), (c) is subject to the (infinitesimal versions of) numerous monoidal compatibilities, which we interpret as the closeness of the corresponding degree 3 element. Similarly,

H^{2}(C^{\bullet}(C,D)(F,F)(\mathrm{id},\mathrm{id}))

is isomorphic to the vector space of the outer infinitesimal deformations of the strong monoidal functor

F

.A relative totalisation

Rp_{*}A(C,D)(F,F)(\mathrm{id},\mathrm{id})

along the projection

p\colon\Theta_{2}\to\Delta

is defined, and it is shown to be a cosimplicial monoid, which fulfils the Batanin–Davydov 1-commutativity condition (Batanin and Davydov (2023)). Then it follows from loc. cit. that

C^{\bullet}(C,D)(F,F)(\mathrm{id},\mathrm{id})

is a

C_{\bullet}(E_{2};\Bbbk)

-algebra. Conjecturally,

C^{\bullet}(C,C)(\mathrm{Id},\mathrm{Id})(\mathrm{id},\mathrm{id})

is a

C_{\bullet}(E_{3};\Bbbk)

-algebra; however, the proof requires more sophisticated methods.
Transjugular intrahepatic portosystemic shunt for esophagogastric variceal bleeding in patients with hepatocellular carcinoma and portal vein tumor thrombus
Authors: Wu Zhi-Qiang , Wang Fan , Wang Feng-Pin , Cai Hong-Jie , Chen Song , Yang Jian-Yong , Guo Wen-Bo 
Published: September 2024

BACKGROUND
Whether hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) and acute esophagogastric variceal bleeding (EGVB) can improve the success rate of endoscopic hemostasis and overall survival (OS) from transjugular intrahepatic portosystemic shunt (TIPS) remains controversial.
AIM
To compare the clinical outcomes between TIPS and standard treatment for such HCC patients.
METHODS
This monocenter, retrospective cohort study included patients diagnosed as HCC with PVTT and upper gastrointestinal bleeding. Patients were grouped by the treatment (TIPS or standard conservative treatment). The success rate of endoscopic hemostasis, OS, rebleeding rates, and main causes of death were analyzed.
RESULTS
Between July 2015 and September 2021, a total of 77 patients (29 with TIPS and 48 with standard treatment) were included. The success rate of endoscopic hemostasis was 96.6% in the TIPS group and 95.8% in the standard treatment group. All the 29 patients in TIPS group successful underwent TIPS procedure and had a better OS compared with standard treatment within the first 160 days after treatment (68 days vs 43 days, P = 0.022), but shorter OS after 160 days (298 days vs 472 days, P = 0.022). Cheng’s Classification of PVTT, total bilirubin and Child-Pugh class were independently negative associated with OS (all P < 0.05). The main causes of death were liver failure or hepatic encephalopathy (75.9%) in the TIPS group and rebleeding (68.8%) in the standard treatment.
CONCLUSION
TIPS could reduce the risk of early death due to rebleeding and prolong short-term survival in HCC patients with PVTT and acute EGVB, which deserves further investigation.
Establishment and evaluation of prediction model of recurrence after laparoscopic choledocholithotomy
Authors: Wu Ying-Jie 
Published: September 2024

BACKGROUND
Choledocholithiasis is a common clinical bile duct disease, laparoscopic choledocholithotomy is the main clinical treatment method for choledocholithiasis. However, the recurrence of postoperative stones is a big challenge for patients and doctors.
AIM
To explore the related risk factors of gallstone recurrence after laparoscopic choledocholithotomy, establish and evaluate a clinical prediction model.
METHODS
A total of 254 patients who underwent laparoscopic choledocholithotomy in the First Affiliated Hospital of Ningbo University from December 2017 to December 2020 were selected as the research subjects. Clinical data of the patients were collected, and the recurrence of gallstones was recorded based on the postoperative follow-up. The results were analyzed and a clinical prediction model was established.
RESULTS
Postoperative stone recurrence rate was 10.23% (26 patients). Multivariate Logistic regression analysis showed that cholangitis, the diameter of the common bile duct, the diameter of the stone, number of stones, lithotripsy, preoperative total bilirubin, and T tube were risk factors associated with postoperative recurrence (P < 0.05). The clinical prediction model was ln (p/1-p) = -6.853 + 1.347 × cholangitis + 1.535 × choledochal diameter + 2.176 × stone diameter + 1.784 × stone number + 2.242 × lithotripsy + 0.021 × preoperative total bilirubin + 2.185 × T tube.
CONCLUSION
Cholangitis, the diameter of the common bile duct, the diameter of the stone, number of stones, lithotripsy, preoperative total bilirubin, and T tube are the associated risk factors for postoperative recurrence of gallstone. The prediction model in this study has a good prediction effect, which has a certain reference value for recurrence of gallstone after laparoscopic choledocholithotomy.