bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protonation constants of endo- and exogenous L-amino acids and their derivatives in aqueous and mixed solution: Unraveling molecular secrets
Authors: Pająk Marek , Fichna Jakub , Woźniczka Magdalena 
Published: October 2024

Abstract
The aim of this review is to summarize the progress made in the determination of the protonation constants of biologically active ligands: endo- and exogenous L-amino acids and their derivatives in aqueous and mixed solutions using different experimental techniques. The knowledge of the protonation constants of the aforementioned ligands is crucial for the determination of the equilibrium constants of complex formation and thus for the understanding of complex biological reactions such as transamination, racemization, and decarboxylation. Thus, the protonation constants of ligands are a measure of their ability to form complexes with metal ions. This knowledge not only helps to understand fundamental biochemical processes, but also has practical applications in areas such as drug design, where ligands are often targeted for therapeutic purposes. The activity of the ligands tends to increase after complexation and their order is consistent with the values of the stepwise dissociation constants of the complexes formed. Understanding the properties of ligands by determining their protonation constants in different environments and their interactions with surrounding molecules is crucial to unraveling the complexity of biological systems.
‘Pirates’, ports, politics: The Gulf (khalīj) & international society’s expansion
Authors: Al Youha Ali 
Published: October 2024

Abstract
This paper examines how Britain, through ‘gunboat diplomacy’ campaigns against so-called Arab pirates, overran the pre-existing Gulf suzerain system and became the predominant power in its waters. By filling a gap in the classical English School ‘international society’ expansion thesis, this article describes how and when political and ideational shifts in the Gulf allowed sovereignty to manifest into its present dynastic form. It argues British imposition of rules, norms, and institutions through a series of nineteenth-century Anglo-Arab treaties against Arab ‘pirates’ broke traditional conditions of divisible sheikhly authority to embed a new telos of sovereign indivisibility, facilitating indirect colonisation. Colonialism as an overlooked primary institution in the classical international society expansion story reinforced political inequality to create dynasticism to simplify colonial statecraft. The 1836 Restrictive Line was a central institution introduced by Britain to manage the transition from divisible to indivisible authority. Drawing from colonial archives, the paper argues that British control over cross-coastal movements through a Restrictive Line reinforced domestic sovereignty of British treaty signatories while weakening agency of maritime sheikhs outside the Anglo-Arab treaties framework. This unsettled traditional structures, transforming maritime tribal confederacies from participation to compliance and reconfiguring Gulf coastal security imperatives for treaty-signatory sheikhs from sea to desert.
Egalitarianism across Generations
Authors: Schmidt Andreas T. 
Published: October 2024

AbstractEgalitarian theories assess when and why distributive inequalities are objectionable. How should egalitarians assess inequalities between generations? One egalitarian theory is (telic) distributive egalitarianism: other things being equal, equal distributions of some good are intrinsically better than unequal distributions. I first argue that distributive egalitarianism produces counterintuitive judgements when applied across generations and that attempts to discount or exclude intergenerational inequalities do not work. This being so, intergenerational comparisons also undercut the intragenerational judgements that made distributive egalitarianism intuitive in the first place. I then argue that egalitarians should shed distributive egalitarianism: relational and instrumental arguments against inequality likely suffice to capture egalitarian concerns – including across generations – without encountering the problems produced by distributive egalitarianism.
Arrhythmias in adult patients after Rastelli surgery: a single-centre experience
Authors: Patloori Sirish Chandra Srinath , Kawada Satoshi , Chakraborty Praloy , Saeed Yawer , Denham Nathan , Joens Christian , Oechslin Erwin N. , Roche Susan L. , Silversides Candice , Wald Rachel M. , Alonso-Gonzalez Rafael , Thorne Sara , Mondesert Blandine , Khairy Paul , Selvaraj Raja , Nair Krishnakumar 
Published: October 2024

AbstractBackground:Rastelli surgery is used for the correction of several CHDs. Although late-onset cardiac arrhythmias have emerged as a major complication after corrective surgeries, there is a paucity of data on arrhythmias after Rastelli surgery.Methods:This retrospective cohort study was conducted on patients who had undergone Rastelli surgery and have been followed at the adult CHD clinic at our hospital.Results:A total of 55 patients (36.4% female, age 22.2 ± 6.4 years) were followed for a median period of 24.2 (20.6–31.0) years. Tachyarrhythmias occurred in 21 (38.4 %) patients (n = 15 for atrial tachycardia, 5 for ventricular tachycardia, and 1 for both atrial and ventricular tachycardia). Older age at surgery was significantly associated with the risk of tachyarrhythmias (P = 0.022). Bradyarrhythmia occurred in 12 (21.8%) patients and consisted of perioperative AV block (n = 5), late AV block (n = 1), and sinus node dysfunction (n = 6). Nine (16.4%) patients underwent catheter ablation. The mechanisms of atrial arrhythmias include cavotricuspid isthmus-dependent and surgical scar-dependent intra-atrial reentrant tachycardias. Among the three patients who underwent ablation for ventricular tachycardia, all circuits were dependent on the scar at the base of the right ventricle to pulmonary artery conduit. Median survival free from any event (arrhythmia, death, or heart failure) was 31.6 (28.1–35.1) years after Rastelli surgery.Conclusions:The prevalence of arrhythmias late after Rastelli surgery is substantial and increases in the second decade after surgery. Older age at surgery is associated with a higher prevalence of arrhythmias.
How do publicly procured school meals programmes in sub-Saharan Africa improve nutritional outcomes for children and adolescents: a mixed-methods systematic review
Authors: Liguori Julia , Osei-Kwasi Hibbah Araba , Savy Mathilde , Nanema Silver , Laar Amos , Holdsworth Michelle 
Published: October 2024

Abstract

Objective:
This review aimed to (i) synthesise evidence of the impact of publicly procured school meals programmes on nutritional outcomes of children/adolescents (5–18 years) in sub-Saharan Africa and (ii) identify challenges and facilitators to implementing effective school meals programmes.

Design:
Mixed-methods systematic review (n 7 databases). Nutritional outcomes assessed were anthropometrics (underweight, stunting, wasting, overweight/obesity), micronutrient deficiencies, food consumed and food environment. Qualitative findings were coded using a nine-step school food system framework: production of food, wholesale and trading, transportation and storage, processing and distribution, food preparation, distribution to students, student stakeholders, community involvement and infrastructure support.

Setting:
Sub-Saharan Africa.

Participants:
Children/adolescents (5–18 years), parents, school personnel and government officials.

Results:
Thirty-three studies (twenty-six qualitative, seven quantitative) from nine sub-Saharan African countries were included. Six studies found a positive impact of publicly procured school meals programmes on nutritional outcomes (wasting (n 1), stunting (n 3), underweight (n 1), vitamin A intake (n 1) and dietary diversity (n 1)). Fifty-three implementation challenges were identified, particularly during food preparation (e.g. training, payment), distribution to students (e.g. meal quantity/quality/diversity, utensils) and infrastructure support (e.g. funding, monitoring, coordination). Implementation facilitators were identified (n 37) across processing and distribution (e.g. programme coordination), student stakeholders (e.g. food preferences, reduced stigma) and community involvement (e.g. engagement, positive perceptions). Included policy recommendations targeted wholesale and trading, food preparation, student stakeholders and infrastructure support in nine, fifteen and twenty-five studies, respectively.

Conclusions:
As many challenges remain, strengthening implementation (and therefore the nutritional impact) of school meals programmes in sub-Saharan Africa requires bold commitment and improved coordination at multiple levels of governance.
IRROTATIONAL FLOW DUE TO FORCED OSCILLATIONS OF A BUBBLE
Authors: COCKERILL MADELEINE C. , FORBES LAWRENCE K. , BASSOM ANDREW P. 
Published: October 2024

AbstractThe behaviour of an axisymmetric bubble in a pure liquid forced by an acoustic pressure field is analysed. The bubble is assumed to have a sharp deformable interface, which is subject both to surface tension and to Rayleigh viscosity damping. Two modelling regimes are considered. The first is a linearized solution, based on the assumption of small axisymmetric deformations to an otherwise spherical bubble. The second involves a semi-numerical solution of the fully nonlinear problem, using a novel spectral method of high accuracy. For large-amplitude nonspherical bubble oscillations, the fully nonlinear solutions show that a complicated resonance structure is possible and that curvature singularities may occur at the interface, even in the presence of surface tension. Rayleigh viscosity at the interface prevents singularity formation, but eventually causes the bubble to become purely spherical unless shape-mode resonances occur. An extended analysis is also presented for purely spherical bubbles, which allows for a more detailed study of the effects of resonance and the Rayleigh viscosity at the bubble surface.
Twins and Their Risks of Cancer as Children, Teenagers or Young Adults: Updated Meta-Analysis and Retrospective Swedish Cohort Study
Authors: Murphy Michael F.G. , He Jian-Rong , Ramakrishnan Rema , Williams Carrie L , Chen Bowang , Hemminki Kari 
Published: October 2024

AbstractWe investigated whether an observed reduction in overall childhood cancer risk (<15 years of age) in twins has been sustained, and how this extends into young adulthood. We searched for English language publications reporting childhood cancer risk in twins, obtained unpublished data directly from some authors, and updated a meta-analysis. We used the Swedish Multigeneration Register to investigate the age to which the reduced overall risk of childhood cancer (observed previously using that Swedish dataset and in this and earlier meta-analyses) persisted into the teenage/young adult years, and which specific tumors accounted for the overall risk reduction beyond childhood. Our meta-analysis of studies of aggregate childhood cancer risk in twins confirmed their approximate 15% reduction in cancer mortality and incidence. Further analysis of Swedish Multigeneration Register data for 1958 to 2002 suggested these reduced risks of cancer (particularly leukaemias and renal tumors) extended from childhood to young adult ages. Reduced risks of these and some other specific tumor types occurring across childhood/teenage/young adult years appeared to account for most of the overall risk reduction. Our results suggest a persistent reduction of overall childhood cancer risk in twins and that this extends into young adulthood. Risk reductions for several specific tumors might account for this and, although there are several potential explanations, intrauterine growth patterns of twins might be a major contributor.
Enhancing Global Simulation of Smoke Injection Height for Intense Pyro‐Convection Through Coupling an Improved One‐Dimensional Plume Rise Model in CAM‐chem
Authors: Ma Chaoqun , Ni Ruijing , Su Hang , Cheng Yafang 
Published: October 2024

AbstractThe impact of wildfire smoke is largely determined by the height where they are injected into the atmosphere. Current plume rise models tend to underestimate the high smoke injection heights because the previous models and configurations were mainly constrained and validated by the plume height observation from Multi‐angle Imaging SpectroRadiometer (MISR), of which most cases inject low within the planetary boundary layer (PBL). Here we retrieve smoke injection heights from intense pyro‐convections based on pyrocumulonimbus satellite images in PYROCAST data set alongside meteorological reanalysis. It largely augments the MISR data set with smoke injection heights up to the upper troposphere and lower stratosphere (UTLS). Constrained by both MISR and PYROCAST, we show that a scaling down of factor 0.2 to the entrainment efficiency parameterized in the one‐dimensional plume‐rise model (1‐D PRM, Freitas et al. (2010, https://doi.org/10.5194/acp‐10‐585‐2010)) significantly improves the model performance for high injection cases without compromising the accuracy of low injection cases. We also found that the fire intensity input can be obtained through a simplified dependence on the biome and biomass burning emission flux. While being unable to represent high cases before, the improved 1‐D PRM model predicts similarly well in injection heights both low near the PBL height and high into the UTLS. The improved 1‐D PRM is then coupled into Community Atmosphere Model with Chemistry (CAM‐chem). The coupled CAM‐chem‐PRM, when predicting injection heights in tests imitating real BB emission, exhibited consistent predictive capabilities with the standalone 1‐D PRM while saw a mere 15% increase of computation time.
Characterizing the Magnetic and Plasma Environment Upstream of Ganymede
Authors: Santos A. , Achilleos N. , Millas D. , Dunn W. , Guio P. , Arridge C. S. 
Published: October 2024

AbstractWe present an application of the latest UCL‐AGA magnetodisc model (MDISC) to the study of the magnetic and plasma conditions in the near‐Ganymede space. By doing this, we provide a comparison with measurements from Juno's most recent flyby of the Jovian moon, perijove 34 (PJ34). We find good agreement between the model results and the magnetometer data, pointing toward a hot plasma index value (2.7190.024)107 Pa m T−1 and an effective magnetodisc radius (79.51.1) Jupiter radii for the Jovian magnetosphere, for the duration of the trajectory, suggesting a configuration with middling levels of expansion. We also predict the plasma conditions observed by Juno during the same flight‐path, as well as the typical conditions over the orbit of Ganymede, with the magnetic and hot plasma pressures assuming dominant roles. Finally, these results are compared with functional fits of a compilation of Galileo flyby data obtained in the vicinity of Ganymede's orbit, suggesting Juno experienced somewhat similar conditions, despite a systematic overestimation in magnetic field intensity in the near‐Ganymede space.
Fault‐Valve Instability: A Mechanism for Slow Slip Events
Authors: Ozawa So , Yang Yuyun , Dunham Eric M. 
Published: October 2024

AbstractGeophysical and geological studies provide evidence for cyclic changes in fault‐zone pore fluid pressure that synchronize with or at least modulate slip events. A hypothesized explanation is fault valving arising from temporal changes in fault zone permeability. In our study, we investigate how the coupled dynamics of rate and state friction, along‐fault fluid flow, and permeability evolution can produce slow slip events. Permeability decreases with time, and increases with slip. Linear stability analysis shows that steady slip with constant fluid flow along the fault zone is unstable to perturbations, even for velocity‐strengthening friction with no state evolution, if the background flow is sufficiently high. We refer to this instability as the “fault valve instability.” The propagation speed of the fluid pressure and slip pulse, which scales with permeability enhancement, can be much higher than expected from linear pressure diffusion. Two‐dimensional simulations with spatially uniform properties show that the fault valve instability develops into slow slip events, in the form of aseismic slip pulses that propagate in the direction of fluid flow. We also perform earthquake sequence simulations on a megathrust fault, taking into account depth‐dependent frictional and hydrological properties. The simulations produce quasi‐periodic slow slip events from the fault valve instability below the seismogenic zone, in both velocity‐weakening and velocity‐strengthening regions, for a wide range of effective normal stresses. A separation of slow slip events from the seismogenic zone, which is observed in some subduction zones, is reproduced when assuming a fluid sink around the mantle wedge corner.
Prediction of Sea Surface Current Around the Korean Peninsula Using Artificial Neural Networks
Authors: Chae Jeong‐Yeob , Jin Hyunkeun , Chang Inseong , Kim Young Ho , Park Young‐Gyu , Kim Young Taeg , Kang Boonsoon , Kim Min‐su , Ju Ho‐Jeong , Park Jae‐Hun 
Published: October 2024

AbstractThe prediction of sea surface currents is essential for various marine activities such as disaster monitoring, fishing industries, and search and rescue operations. Continuous improvements in numerical models have made it possible to predict more realistic oceans using data assimilation and fine spatial resolution. However, such complicated ocean models require high computational power and time, making them difficult to use for near‐real time forecasting. To compensate for these high computational costs, novel approaches with efficient computational costs combined with numerical model outputs need to be developed. Artificial neural networks could be one of the solutions as they require low computational power for prediction, owing to pre‐trained networks. Here, we present a prediction framework applicable to surface current prediction in the seas around the Korean Peninsula using three‐dimensional (3‐D) convolutional neural networks. The network is based on a 3‐D U‐shaped network structure and is modified to predict sea surface currents using oceanic and atmospheric variables. The forecast procedure is optimized to minimize the error of the next day's sea surface current field with a spatial resolution of 1/24° and its recursively predicting structure allows more days to be predicted. The network performance is evaluated by changing the input days and variables to find the optimal surface‐current‐prediction artificial neural network model. The optimized model shows a root mean squared error of 2.3 cm/s for the first forecast day, demonstrating its strong potential for practical use in the near future.
Tectonic Inversion of Intracontinental Basins and the Conundrum of Plate‐Scale Stress Propagation: The Case of the Jatobá Basin, NE Brazil
Authors: Marques F. O. , Palhano L. C. , Vasconcelos D. L. , Nogueira F. C. C. , Tavares A. C. , Bezerra F. H. , Maia R. P. , Medeiros W. E. , Dantas R. R. S. , Fuck R. A. , de Oliveira R. G. 
Published: October 2024

AbstractWe chose the Jatobá Basin (JB) in the Borborema Province in northeastern Brazil to address two outstanding problems, basin tectonic inversion and stress propagation, because (a) evidence of tectonic inversion is conspicuous in the JB, and (b) the basin sits on intracontinental northeastern Brazil, far from plate boundaries and the most obvious stress sources. We found robust evidence of oblique reverse faulting inside the basin, putting sediments of the JB's depocenter hundreds of meters above the hard granitic host basement. We also found sound evidence of hydrographic flow reversal, that is, earlier basement‐to‐basin runoff, followed by basin‐to‐basement runoff. This change means that formerly the basement stood higher than the basin, and later the basin was uplifted (inverted) to currently stand hundreds of meters higher than the basement, especially where the gravity anomaly map shows the deepest depocenter. Coarse conglomerates, sourced in the uplifted basin and blanketing the adjacent basement for kilometers, are only cut by the current hydrographic network. From these main lines of evidence, we infer recent basin tectonic inversion (Quaternary, i.e., <2.6 Ma?). The WSW‐ENE orientation of the maximum compressive stress needed to invert the basin likely results from Mid‐Atlantic and Andean pushes. We conclude that lithospheric plates can deform in their cores because of stresses propagating from plate boundaries to distant plate interiors, where the lithosphere has been locally weakened and strain has concentrated.
The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment
Authors: Feng Maoxiao , Jiao Qinlian , Ren Yidan , Liu Xiaoyan , Gao Zihan , Li Zhengjun , Wang Yunshan , Zhao Miaoqing , Bi Lei 
Published: October 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) is a common malignant tumor of the digestive tract. Although gemcitabine and other therapeutic agents are effective in patients with advanced and metastatic pancreatic cancer, drug resistance has severely limited their use. However, the mechanisms of gemcitabine resistance in pancreatic cancer are poorly understood. In this study, ATAC-seq, ChIP-seq, and RNA-seq were performed to compare chromatin accessibility and gene expression in a patient-derived tumor xenograft (PDX) model of pancreatic cancer with or without gemcitabine resistance. Analyzing these sequencing data, we found a dramatic change in chromatin accessibility in the PDX model of gemcitabine-resistant tissues and identified a key gene, UBR7, which plays an important role in mediating gemcitabine resistance. Further research found that depletion of UBR7 significantly increased pancreatic carcinogenesis and the immunosuppressive microenvironment. Mechanistically, depleted UBR7 increased the stability of PRMT5, thereby promoting glycolysis in pancreatic cancer cells. Finally, an inhibitor that blocks PRMT5 (DS-437) significantly reduced gemcitabine resistance in pancreatic cancer caused by UBR7 depletion. In conclusion, our results illustrate that the UBR7-PRMT5 axis is a key metabolic regulator of PDAC and a promising target for the clinical treatment of gemcitabine resistance in PDAC.
Light-modulated neural control of sphincter regulation in the evolution of through-gut
Authors: Yaguchi Junko , Sakai Kazumi , Horiuchi Atsushi , Yamamoto Takashi , Yamashita Takahiro , Yaguchi Shunsuke 
Published: October 2024

AbstractThe development of a continuous digestive tract, or through-gut, represents a key milestone in bilaterian evolution. However, the regulatory mechanisms in ancient bilaterians (urbilaterians) are not well understood. Our study, using larval sea urchins as a model, reveals a sophisticated system that prevents the simultaneous opening of the pylorus and anus, entry and exit points of the gut. This regulation is influenced by external light, with blue light affecting the pylorus via serotonergic neurons and both blue and longer wavelengths controlling the anus through cholinergic and dopaminergic neurons. These findings provide new insights into the neural orchestration of sphincter control in a simplified through-gut, which includes the esophagus, stomach, and intestine. Here, we propose that the emergence of the earliest urbilaterian through-gut was accompanied by the evolution of neural systems regulating sphincters in response to light, shedding light on the functional regulation of primordial digestive systems.