bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bertolotti Syndrome: Prevalence and Clinical Implications in a West African Population
Authors: Ogolo Donald , Ajare Enyereibe C. , Okwunodulu Okwuoma , Ndubuisi Chika A. , Mezue Wilfred , Ohaegbulam Samuel C. 
Published: September 2024

Abstract

Aims:
This study examines the prevalence and clinical implications of lumbosacral transitional vertebrae (LSTV), specifically lumbarization and sacralization, in a West African population. It aims to assess the association between LSTVs and low back pain, considering the potential for these anatomical variations to contribute to degenerative spinal conditions.

Materials and methods:
Over a 5-year period, 4788 patients underwent lumbosacral 1.5T MRI scans to identify the prevalence of LSTV and its types. The study analyzed the data, focusing on the correlation between LSTV, low back pain, and degenerative changes such as listhesis and disc protrusion/extrusion.

Results:
The prevalence of LSTV in the study population was found to be 2.07%, with a notable gender disparity in the occurrence of specific LSTV types. The findings also revealed a significant association between LSTV and low back pain, particularly among younger patients. Additionally, LSTV was linked to early-onset or accelerated degenerative changes in the spine.

Conclusion:
LSTV is a clinically relevant condition with a specific prevalence in the West African population, associated with low back pain and degenerative spinal changes. These findings underscore the importance of recognizing LSTV in the clinical assessment and management of patients with low back pain. The study suggests further research into the genetic, biomechanical, and environmental factors contributing to LSTV to improve patient care.
B-Mode Ultrasound Grading of Nonalcoholic Fatty Liver Disease and Association with Intima-media Thickness: A Case–Control Study
Authors: Baduku Tokan Silas , Ibinaiye Philip Oluleke , Igashi Joseph Bako , Usman Bello Omuya , Manko Muhammad , Ahmad Abdurrahman El-fulaty , Tabari Abdulkadir Musa , Mustapha Shettima Kagu , Olarinoye-Akorede Adebanke Sefiya , Balogun Muhammad Shakir 
Published: September 2024

Abstract

Background:
Nonalcoholic fatty liver disease (NAFLD) is the infiltration of the liver cells with fat of up to at least 5% and above. It is the type of fatty infiltration that is, not associated with alcohol intake, and is the “hepatic expression” of a metabolic syndrome that affects a wide spectrum of people. It is now a disease entity in today’s society, as it is fast becoming an emerging public health problem in the medical community. This is a result of the changing life patterns in society. The incidence and prevalence of cardiovascular anomalies as depicted by changes in the vascular walls of blood vessels has been linked with NAFLD.

Objective:
To determine the association between NAFLD and carotid intima-media thickness (CIMT) among adult Nigerians.

Subjects and Methods:
This was a case–control study involving 181 apparently healthy subjects with NAFLD and an equal number of apparently normal subjects without NAFLD matched for age and gender. The CIMT was assessed in both groups. This makes for a total number of 362 subjects. They were recruited from ABUTH’s staff members and students and the General Out-patient/Family Medicine Clinic of ABUTH, Zaria. This study was approved by the Ethical Committee of ABUTH, and all patients signed informed consent prior to their enrollment.

Results:
A total of 362 subjects were involved in the study. Both the NAFLD patients and control populations had 98 (54.1%) females and 83 (45.9%) males each, with the age range of both between 20 and 70 years of age. The Wilcoxon matched-pairs comparison test showed no significant difference in the ages of the two study groups. The development of NAFLD had significant association with age, subject’s occupation and area of residence, while there was no significant Association of development of NAFLD with sex, marital status and educational attainment. Also, there was statistically significant increase in CIMT in subjects with NAFLD when compared with the control group (P ≤ 0.0001). The values suggested a steady increase with progression from mild, moderate to severe NAFLD.

Conclusion:
Our study showed a statistically significant increase of association between nonalcoholic fatty liver disease (NAFLD) and CIMT when compared with the control group in our environment.
Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells
Authors: Wang Zhuo-Ran , Zhang Cun-Zhen , Ding Zhan , Li Yi-Zhuo , Yin Jian-Hua , Li Nan 
Published: September 2024

BACKGROUND
Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ineffective. Tumor-associated immune cells are critical for tumor development and progression. The main goal of this study was to establish models based on tumor-associated immune cells for predicting the overall survival of patients undergoing surgery for ICC.
AIM
To establish 1-year and 3-year prognostic models for ICC after surgical resection.
METHODS
Immunohistochemical staining was performed for CD4, CD8, CD20, pan-cytokeratin (CK), and CD68 in tumors and paired adjacent tissues from 141 patients with ICC who underwent curative surgery. Selection of variables was based on regression diagnostic procedures and goodness-of-fit tests (PH assumption). Clinical parameters and pathological diagnoses, combined with the distribution of immune cells in tumors and paired adjacent tissues, were utilized to establish 1- and 3-year prognostic models.
RESULTS
This is an important application of immune cells in the tumor microenvironment. CD4, CD8, CD20, and CK were included in the establishment of our prognostic model by stepwise selection, whereas CD68 was not significantly associated with the prognosis of ICC. By integrating clinical data associated with ICC, distinct prognostic models were derived for 1- and 3-year survival outcomes using variable selection. The 1-year prediction model yielded a C-index of 0.76 95% confidence interval (95%CI): 0.65-0.87 and the 3-year prediction model produced a C-index of 0.69 (95%CI: 0.65-0.73). Internal validation yielded a C-index of 0.761 (95%CI: 0.669-0.853) for the 1-year model and 0.693 (95%CI: 0.642-0.744) for the 3-year model.
CONCLUSION
We developed Cox regression models for 1-year and 3-year survival predictions of patients with ICC who underwent resection, which has positive implications for establishing a more comprehensive prognostic model for ICC based on tumor immune microenvironment and immune cell changes in the future.
Characteristics and risk factor analyses of high-grade intraepithelial neoplasia in older patients with colorectal polyps
Authors: Zhang Xin , Wang Ying , Zhu Tong , Ge Jian , Yuan Jun-Hua 
Published: September 2024

BACKGROUND
According to the degree of intradermal neoplasia in the colorectal exhalation, it can be divided into two grades: Low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia (HGIN). Currently, it is difficult to accurately diagnose LGIN and HGIN through imaging, and clinical diagnosis depends on postoperative histopathological diagnosis. A more accurate method for evaluating HGIN preoperatively is urgently needed in the surgical treatment and nursing intervention of colorectal polyps.
AIM
To explore the characteristics and risk factors of HGIN in older patients with colorectal polyps.
METHODS
We selected 84 older patients diagnosed with HGIN as the HGIN group (n = 95 colonic polyps) and 112 older patients diagnosed with LGIN as the LGIN group (n = 132 colonic polyps) from Shandong Provincial Hospital Affiliated to Shandong First Medical University. The endoscopic features, demographic characteristics, and clinical manifestations of the two patient groups were compared, and a logistic regression model was used to analyze the risk factors for HGIN in these patients.
RESULTS
The HGIN group was older and had a higher number of sigmoid colon polyps, rectal polyps, pedunculated polyps, polyps ≥ 1.0 cm in size, polyps with surface congestion, polyps with surface depression, and polyps with villous/tubular adenomas, a higher proportion of patients with diabetes and a family history of colorectal cancer, patients who experienced rectal bleeding or occult blood, patients with elevated carcinoembryonic antigen (CEA) and cancer antigen 199 (CA199), and lower nutritional levels and higher frailty levels. The polyp location (in the sigmoid colon or rectum), polyp diameter (≥ 1.0 cm), pathological diagnosis of (villous/tubular adenoma), family history of colorectal cancer, rectal bleeding or occult blood, elevated serum CEA and CA199 levels, lower nutritional levels and higher frailty levels also are independent risk factors for HGIN.
CONCLUSION
The occurrence of high-grade neoplastic transformation in colorectal polyps is closely associated with their location, size, villous/tubular characteristics, family history, elevated levels of tumor markers, and lower nutritional levels and higher frailty levels.
Nationwide questionnaire survey on pediatric pancreatic tumors in Japan
Authors: Makita Satoshi , Uchida Hiroo , Kano Motohiro , Kawakubo Naonori , Miyake Hiromu , Yoneda Akihiro , Tajiri Tatsuro , Fukumoto Koji 
Published: September 2024

BACKGROUND
Pediatric pancreatic tumors are rare and account for < 0.1% of all childhood cancers. The primary treatment for pancreatic tumors is surgical resection. However, because of the lack of knowledge regarding pediatric pancreatic tumors, no comprehensive treatment plans for pediatric pancreatic tumors have been developed.
AIM
To compared the clinical features, treatment methods, and prognosis of pediatric pancreatic tumors in Japan with those in other countries.
METHODS
Questionnaires were sent to 213 pediatric surgical units in Japan. Pancreatic tumors that were not surgically treated were excluded from the survey. The primary survey investigated the number of patients aged 0-18 years who underwent pancreatic tumor surgery and the type of tumors managed during the 22-year study period (from January 1, 2000 to December 31, 2021) by post card. The secondary survey assessed the clinical images, treatment methods, and tumor outcomes via email.
RESULTS
The primary survey enrolled 228 patients. In the secondary survey, 213 patients were eventually enrolled. The most common type of pancreatic tumor was solid pseudopapillary neoplasm (SPN) [n = 164 (77.0%)], followed by pancreatoblastoma [n = 16 (7.5%)], pancreatic endocrine tumor [n = 14 (6.6%)], non-epithelial tumor [n = 9 (4.2%)], pancreatic tumor [n = 7 (3.3%)], and metastatic pancreatic tumor [n = 3 (1.4%)]. Overall, 123 (57.7%) patients underwent distal pancreatectomy, of whom 49 underwent laparoscopic surgery. Forty-four (20.7%) patients underwent enucleation, of whom eight underwent laparoscopic surgery. Thirty-two (15.0%) patients underwent pancreaticoduodenectomy, of whom one underwent laparoscopic surgery. All patients with SPN, including those with distant metastases and recurrent disease, survived.
CONCLUSION
SPN was more common in Japan than in other countries. Regardless of the histological type, resection is the most effective treatment for pediatric pancreatic tumors.
Burden landscape of hepatobiliary and pancreatic cancers in Chinese young adults: 30 years’ overview and forecasted trends
Authors: Chen De-Sheng , Chen Ze-Ping , Zhu Dong-Zi , Guan Lv-Xin , Zhu Qi , Lou Yi-Chao , He Ze-Ping , Chen Hao-Nan , Sun Hong-Cheng 
Published: September 2024

BACKGROUND
Hepatobiliary and pancreatic (HBP) cancers impose a considerable burden on young populations (aged 15 to 49 years), resulting in a substantial number of new cases and fatalities each year. In young populations, the HBP cancers shows extensive variance worldwide and the updated data in China is lacking.
AIM
To investigate the current status, trends, projections, and underlying risk factors of HBP cancers among young populations in China.
METHODS
The Global Burden of Disease Study 2019 provided data on the annual incidence, mortality, disability-adjusted life years (DALYs), age-standardized incidence rate (ASIR), mortality rate (ASMR), and DALYs rate (ASDR) of HBP cancers in young Chinese adults between 1990 and 2019. Temporal trends were assessed using estimated annual percentage change and hierarchical clustering. Sex-specific mortality and DALYs caused by various risks were analyzed across China and other regions, with future trends until 2035 projected using the Bayesian age-period-cohort model.
RESULTS
From 1990 to 2019, incident cases, deaths, DALYs, ASIR, ASMR, and ASDR for liver cancer (LC) in young Chinese individuals decreased, classified into 'significant decrease' group. Conversely, cases of gallbladder and biliary tract cancer and pancreatic cancer rose, categorized as either 'significant increase' or 'minor increase' groups. The contribution of risk factors to mortality and DALYs for HBP tumors increased to varying degrees. Healthy lifestyle behaviors, such as tobacco control, weight management, alcohol moderation, and drug avoidance, could lower HBP cancers incidence. Moreover, except for LC in females, which is likely to initially decline slightly and then rise, the forecasting model predicted that the ASIR and ASMR for all HPB cancers subtypes by gender will increase among young adults.
CONCLUSION
HBP cancers burden among young adults in China is expected to increase until 2035, necessitating lifestyle interventions and targeted treatment strategies to mitigate the public health impact of these cancers.
Abordagem Temática no contexto da BNCC: discussões a partir da produção de um material didático-pedagógico
Authors: Carvalho Pacheco Lucas , Sturza Loy Laíza , Muenchen Cristiane 
Published: September 2024

Na contramão das teorias tradicionais de currículo, está inserida a perspectiva curricular da Abordagem Temática. Nesta, a organização dos conhecimentos científicos é realizada a partir de um tema da realidade local/global dos educandos. Nessa perspectiva e no contexto das novas políticas curriculares brasileiras, este estudo almeja apresentar e discutir o processo de construção do material didático-pedagógico “Lixo na região oeste de Santa Maria/RS: quais são os problemas e as possibilidades?”, assim como suas potencialidades para o desenvolvimento de aulas interdisciplinares, problematizadoras, críticas e dialógicas. Para atingir este propósito, organizamos as discussões em quatro tópicos/categorias, sendo eles(as): i) O processo de estruturação das Unidades Temáticas; ii) O potencial interdisciplinar; iii) Os Três Momentos Pedagógicos como estruturantes de materiais didático-pedagógicos e iv) A BNCC e as novas políticas curriculares. Dentre os relevantes resultados deste estudo, constatamos a possibilidade de articulação da Abordagem Temática com as novas políticas curriculares, sem que a Abordagem Temática tenha qualquer adaptação em sua fundamentação teórica, metodológica e/ou epistemológica.
Playwork in Practice
Authors: Wood Ali , Sexton Julia , Kilvington Jacky 
Published: September 2024

Playwork in Practiceintroduces the ways that playwork can be used across the children’s workforce, including carers, qualified teachers, parents and other adults.You will learn the theoretical and practical aspects of the playwork approach supported by a wealth of research-evidence, this book is for anyone studying playwork or looking to use it in their own practice.
The chapters focus on the following areas where the playwork approach can be applied: behaviour, adult expectations, relationships and inclusion, space, environment and outdoors, age, risk, and resilience, emotions and resilience, health, well-being and gender. Using a reflexive reflective approach, the book offers vivid descriptions of interactions between children and adults in a range of different circumstances and analyses these interactions critically. Each chapter includes a real-life story with analysis based on the authors conversations with carers, playworkers, parents and other adults. The chapters also include reflective questions.
Transmission of the Book of the Dead in New Kingdom Tombs at Saqqara
Authors: Davies H.P.R. Twiston 
Published: September 2024

Texts and images from theBook of the Deadwere widely used to decorate the walls of tombs during Egypt’s New Kingdom (c. 1550-1077 BCE).Prior research has tended to focus on either individual tombs, or on the contents of papyrus copies of theBook of the Dead. This book focusses on the adaptation of parts of this funerary corpus in individual tombs from the New Kingdom necropolis at Saqqara, with the aim of showing how each tomb’s decoration was tailored to the ends of their builders. In doing so, it builds up a picture of the ways in which these developments changed over time, and captures the dynamic and shifting ways in which ancient Egyptians interacted with their funerary texts. This contrasts with the popular image of Egyptian religion as centrally administered and directed, and essentially unchanging over millennia. In fact, choices and forms of texts and images used in tombs changed even within a single generation. Some forms remained popular over long periods, being constantly reused and re-adapted, while others achieved specific and local popularity, or else were abandoned after only a short period of time. This book argues powerfully for the human dimension in ancient Egyptian religion, revealing the ways in which individuals and groups continually reshaped their tradition even as they worked within it. Produced as part of the research project The Walking Dead at Saqqara: The Making of a Cultural Geography, this book is kindly funded by the Dutch Research Council (NWO).
The eBook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollections.com. Open access was funded by the Dutch Research Council (NWO): 276-30-016.
Persephone Myth in Young Adult Fiction
Authors: González Cristina Salcedo 
Published: September 2024

Investigating the widespread but understudied presence of the Persephone myth within 21st-century young adult literature, Cristina Salcedo González analyses six young adult novels which incorporate a reworking of this ancient Greek myth.Through the identification of mythic themes (‘mythemes’) and patterns within these novels, González shows that these works evoke the female life cycle and develop current perceptions of the female maturational experience. As a result, González makes an important contribution in establishing the cultural significance of young adult literature in the world of classical reception. These novels, all written by women, also inflect or interpret the myth in ways influenced by their contemporary contexts, specifically the impact of the novels’ target readership on the aspects of the myth that are either emphasised (e.g. Persephone’s descent into the underworld; her existence there; and her re-ascent) or de-emphasised (e.g. the mourning and wanderings of Demeter).
This book makes original methodological contributions – through its innovative dual perspective of myth criticism and classical reception – to our understanding of the academically neglected genre of young adult literature and the reception of the myth of Persephone. As a result, González makes an important contribution in establishing the cultural significance of young adult literature in the world of classical reception.
Women in Allied Naval Intelligence in the Second World War
Authors: Miller Sarah-Louise 
Published: September 2024

Closely examining the work of women in the US and British naval services towards Allied naval intelligence during the Second World War, this book focuses on their contributions during the Battle of the Atlantic and Pacific Naval War, in order to shed new light on arenas of war from which women’s narratives are almost always absent.
Including personal testimonies from those involved, and surveying a wide cross-section of different roles, Sarah-Louise Miller analyses the work of women at every level and rank in the US and British naval services, and offers a much wider picture of how they assisted the Allied forces behind closed doors.
With exploration of the work of the WRNS and WAVES on developing naval intelligence, this book argues that they played a crucial role in the British and American SIGINT systems, and within programs such as those at Bletchley Park and OP-20-G – therefore directly impacting the organisation and outcome of Anglo-American naval efforts. Including analysis of the development of the modern ‘kill-chain’, Miller also re-evaluates the effect of the ‘combat taboo’, to demonstrate that the WRNS and WAVES were in fact at the cutting edge of the emergence of modern warfare.
Metaphysical Hermeneutics
Authors: Grondin Jean 
Published: September 2024

If in its simplest form, hermeneutics is a quest for understanding, then part of that quest will always include striving to understand being and the meaning of being.This open access book takes that ambition seriously, arguing that hermeneutics and metaphysics, so central to philosophical thought but so rarely put in tandem, are two complementary fundamentals of human existence.
Metaphysical Hermeneuticsputs forward the argument for a hermeneutical metaphysics in service of philosophy’s basic aim: to make sense of our experience. Jean Grondin builds his argument for this combined discipline around the idea of ‘sense’ – a theme that is both hermeneuticalandmetaphysical. What we seek to glimpse is not just a figment of the mind but always the meaning ofsomething. Grondin calls on one of the founding figures of contemporary hermeneutics Hans-Georg Gadamer to test his theories, singling out the metaphysical dimension of Gadamer’s ideas and questioning his seeming embrace and rejection of that dimension. Rooting these questions in the human search for meaning is a major contribution to the scope and resources of hermeneutic philosophy.
The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollections.com.Open access was funded by the Department of Philosophy at the University of Montreal.
Dil Chahta Hai Soundtrack
Authors: Beaster-Jones Jayson 
Published: September 2024

The 2001 buddy film Dil Chahta Hai (dir. Farhan Akhtar), had arguably the first rock soundtrack in Bollywood. The award-winning soundtrack is an entry point into the relationship between Bollywood film songs, Hindi language music, and the Indi-pop movement of the '80s and '90s.
Beaster-Jones draws from reviews by music critics and fans, industry interviews, and his own close analysis of the music and the film to trace the role of the Dil Chahta Hai soundtrack in transforming both the sound and production practices of Bollywood cinema in the new millennium. These songs emerged from the rock band and live performance aesthetic of writing trio Shankar-Ehsaan-Loy. Their collaborative compositional approach for this soundtracks and later soundtracks reveals the changing tastes of India’s urban youth audiences and how that taste fueled the rise of the rockstar narrative in Hindi films.
The music for this soundtrack was the second Bollywood soundtrack composed by the superstar trio Shankar-Ehsaan-Loy (i.e. Shankar Mahadevan, Ehsaan Noorani, Loy Mendonsa), with lyrics penned by the inimitable Javed Akhtar. The songs from this soundtrack paved the way for the rock and EDM-oriented compositions of Hindi-language cinema that came to dominate the first decades of the 21st century, making Dil Chahta Hai among the most influential soundtracks in Indian cinematic history.