bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT AND PROGRESSION OF A LAMELLAR MACULAR HOLE WITH LAMELLAR HOLE–ASSOCIATED EPIRETINAL PROLIFERATION
Authors: Compera Denise , Cereda Matteo G. , Schumann Ricarda G. , Bottoni Ferdinando 
Published: June 2017

Purpose:
To describe evolution and progression of a lamellar macular hole (LMH) with “lamellar hole–associated epiretinal proliferation (LHEP)” using spectral-domain optical coherence tomography and fundus autofluorescence.

Methods:
Observational case report.

Results:
We report on a 63-year-old male patient demonstrating a complete history of LMH development with LHEP occurring during a follow-up period of 8 years. Presenting with a normal foveal contour and attached posterior vitreous at first visit, an LMH developed shortly after incomplete posterior vitreous detachment with vitreopapillary adhesion. On spectral-domain optical coherence tomography images, progression of the LMH including enlargement of the intraretinal cavitation and decrease in the retinal thickness were documented. An increase of LHEP was first documented 6 months after LMH evolution. One month after cataract surgery and 6 years after the first visit, a full-thickness macular hole developed that closed spontaneously after 4 weeks. Localization of LHEP had moved into the foveal defect toward the outer retinal layers. Thereafter, the LMH was stable, and the patient presented with a visual acuity of 20/25.

Conclusion:
Proper follow-up time is important for studying eyes with an LMH. Epimacular cell proliferation shows progression over time that appears to be associated with morphologic changes of the LMH including shape of the lamellar defect, amount of LHEP, and contractive properties of epiretinal tissue. The presence of LHEP was documented shortly after posterior vitreous detachment.
Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants < 32 Weeks Gestational Age: A Randomized Controlled Study
Authors: Ben Jmaa Wissal , Hernández Alfredo I. , Sutherland Megan R. , Cloutier Anik , Germain Nathalie , Lachance Christian , Martin Brigitte , Lebel Marc H. , Pladys Patrick , Nuyt Anne Monique 
Published: June 2017

Background:
Inflammation may depress respiration in neonates. This study aimed to establish a link between postimmunization inflammation and cardio-respiratory events (CREs).

Methods:
Randomized double-blind controlled study of infants born < 32 weeks gestation receiving the 2 months vaccine, which comprised diphtheria and tetanus toxoids and acellular pertussis adsorbed combined with inactivated poliomyelitis vaccines and Haemophilus b conjugate and the pneumococcal conjugate 10-valent vaccines. Infants were randomized to ibuprofen treatment or a placebo group (n = 28/group). C-reactive protein (CRP) and prostaglandins E2 (PgE2) levels were assessed before and after immunization. CREs were recorded for 72 hours. Heart rate variability was assessed by polysomnography.

Results:
In the placebo group, immunization was associated with significantly increased CRP levels and an increase in CRE (8.6 ± 11.1 before versus 14.0 ± 12.8 after), which did not reach statistical significance (P = 0.08), and no change in PgE2. The increase in CRP was correlated with changes in CRE (r = 0.4: P < 0.05). In the ibuprofen group, immunization significantly increased CRP levels but was not associated with change in CRE (6.7 ± 7.7 before versus 6.8 ± 9.7 after) and PgE2 levels. Comparing the groups, variation in CRE (ΔCRE before versus after immunization) was significantly lower in the ibuprofen group (0.1 ± 7.9 versus 5.4 ± 10.0 ΔCRE; P < 0.05).

Conclusion:
The first immunization of infants born < 32 weeks was associated with an increase in CRP. Ibuprofen treatment significantly attenuated the variation (Δ) in CRE following first immunization in these infants but the current study could not demonstrate an impact on CRP and PgE2 levels. The impact of anti-inflammatory treatment on antigenicity must be evaluated before their clinical use aiming at reducing CRE after immunization in preterm infants.
Self-Reported Physical Activity Level in Student Athletes at Preparticipation Physical Evaluations
Authors: Valasek Amy E. , Bieganski Madison , Desrochers Jana , Young Julie 
Published: June 2017

Objective:
Quantify physical activity in healthy student athletes.

Design:
Cross-sectional survey.

Setting:
Five Central Ohio schools during mass preparticipation physicals.

Participants:
Three hundred sixty-five children between the ages 10 and 18 years.

Independent Variables:
Days per week of moderate to vigorous physical activity (MVPA), minutes per day of MVPA, and number of activities.

Main Outcome Measures:
Minutes per week of MVPA.

Results:
One hundred eighty high school and 177 middle school subjects responded to the survey. There were 198 male and 162 female respondents. Mean age recorded 14.2 ± 1.7 years. There were no differences in activity volume based on sex. Mean minutes per week of MVPA reported 316.0 ± 231.0. High school subjects reported fewer activities than middle school cohort 2.7 ± 1.2 versus 3.2 ± 1.5 (P < 0.05).

Conclusion:
Only 7% of respondents reported exercising 60 minutes daily. Twenty-seven percent of respondents met minutes per week (420 minutes of MVPA) by training in large volumes on fewer days. Surprisingly, this physically active population did not meet the national standards of daily MVPA. In addition, middle school athletes reported more variety of activities compared with high school athletes surveyed which reached statistical significance. Screening for daily physical activity is important in the athletic population because young athletes may not meet daily MVPA recommendations.
The Hannover Coupler: Controlled Static Prestress in Round Window Stimulation With the Floating Mass Transducer
Authors: Müller Mathias , Salcher Rolf , Lenarz Thomas , Maier Hannes 
Published: June 2017

Introduction:
Stimulation of the cochlear round window (RW) with the floating mass transducer (FMT) still suffers from large variation in clinical outcomes. Beside the geometric mismatch between RW and FMT diameter that is a known limiting factor in achieving optimal coupling between actuator and RW membrane, the applied static force between FMT and RW is usually undefined. In this study, the feasibility and efficacy of a specially designed FMT coupler permitting application of static preloads to the RW membrane to optimize FMT-RW coupling was investigated.

Methods:
Experiments were performed in fresh human cadaveric temporal bones. The “Hannover Coupler” FMT-prosthesis has a spherical tip (d=0.5 mm) at the front end and a spring at the prosthesis back that enables the application of static preloads and mobility of the FMT at the same time. Stapes footplate (SFP) displacements in response to acoustic stimulation of the tympanic membrane and to RW stimulation by the FMT were measured by a Laser-Doppler vibrometer.

Results:
Average SFP displacement responses of ASTM standard F2504-05 compliant temporal bones to RW stimulation by the “Hannover Coupler” were dependent on the applied force (∼0–100 mN) and increased by up to 25 dB at frequencies ≥ 1 kHz. When averaged at speech relevant frequencies (0.5, 1, 2, 4 kHz) SFP displacements showed a global maximum at RW preloads of ∼4 mN.

Conclusion:
The coupling between FMT and RW membrane was improved by the application of static RW preloads as indicated by increased SFP amplitudes to RW stimulation.
The Influence of Intraoperative Testing on Surgical Decision-making During Cochlear Implantation
Authors: Page Joshua Cody , Murphy Linda , Kennett Sarah , Trinidade Aaron , Frank Robert , Cox Matthew , Dornhoffer John L. 
Published: June 2017

Objective:
To review our use of intraoperative testing during cochlear implantation (CI) and determine its impact on surgical decision-making.

Study Design:
Retrospective chart review.

Setting:
Tertiary referral center.

Patients:
A total of 197 children and adults who underwent a total of 266 primary and/or revision CI by a single surgeon from 2010 to 2015.

Intervention:
Intraoperative electrophysiologic monitoring including evoked compound action potentials and electrical impedances.

Main Outcome Measures:
Whether surgical management was changed based on intraoperative testing.

Results:
In only 2 of 266 patients (0.8%), the back-up device was used due to findings on intraoperative testing. In three patients (1.1%), X-ray was performed intraoperatively to confirm intracochlear electrode placement, which was found to be normal in all patients.

Conclusion:
Our data suggest that with respect to CI in children and adults in straightforward cases (e.g., normal anatomy, nondifficult insertion, etc.), routine intraoperative evoked compound action potentials, impedances, and imaging rarely influence surgical decision-making in our clinic and may have limited usefulness in these patients. The implications of this are discussed and a review of the literature is presented.
Diagnosis of Superior Semicircular Canal Dehiscence in the Presence of Concomitant Otosclerosis
Authors: Yong Michael , Zaia Erica , Westerberg Brian , Lea Jane 
Published: June 2017

Objective:
To review three patients with concurrent otosclerosis and superior canal dehiscence identified before operative intervention and provide a practical diagnostic approach to this clinical scenario.

Study Design:
Retrospective patient series.

Setting:
Tertiary/quaternary referral center.

Patients:
Individuals with confirmed diagnoses of concurrent otosclerosis and superior semicircular canal dehiscence syndrome.

Interventions:
Detailed history and physical examinations were performed on these patients, as well as detailed audiovestibular testing and computed tomography imaging.

Main Outcome Measures:
Establishing a clear diagnosis of concurrent otosclerosis and superior semicircular canal dehiscence syndrome using a thorough diagnostic approach.

Results:
Three patients presented with conductive hearing loss and normal tympanic membranes. When history and physical examination yielded suspicious third window symptoms/signs, more detailed audiovestibular testing and computed tomography scan imaging were performed. All three patients were ultimately identified to have concurrent otosclerosis and superior canal dehiscence. Conservative management was the option of choice for two of these patients (trial of a hearing aid) and surgical intervention was performed to treat the otosclerosis in the remaining patient.
Ser/Thr protein kinase Bβ-NADPH oxidase 2 signaling in thromboinflammation
Authors: Li Jing , Cho Jaehyung 
Published: June 2017

Purpose of review
Interactions between neutrophils and platelets contribute to the progression of thromboinflammatory disease. However, the regulatory mechanism governing these interactions is poorly understood. The present review focuses on the crucial role of Ser/Thr protein kinase B (AKT)β-NADPH oxidase 2 (NOX2) signaling in regulating neutrophil and platelet activation and their heterotypic interactions under thromboinflammatory conditions.

Recent findings
Growing evidence has shown that platelets, leukocytes, and blood coagulation need to be considered to treat thromboinflammatory disease in which inflammation and thrombosis occur concurrently. In addition to plasma proteins and intracellular signaling molecules, extracellular reactive oxygen species (ROS) produced from activated leukocytes could be an important factor in the pathophysiology of thromboinflammatory disease. Recent studies reveal that AKT2-NOX2 signaling has critical roles in Ca2+ mobilization, ROS generation, degranulation, and control of the ligand-binding function of cell surface molecules, thereby promoting heterotypic cell–cell interactions in thromboinflammation. These findings have provided novel insights into attractive therapeutic targets for the prevention and treatment of thromboinflammatory disease.

Summary
Recent discoveries concerning molecular mechanisms regulating neutrophil–platelet interactions have bridged some gaps in our knowledge of the complicated signaling pathways exacerbating thromboinflammatory conditions.
A Forensic Epidemiological Study of Homicide in Isfahan Province and Review of the Literature
Authors: Karimi Jalal , Koehler Steven A. , Karimi Roya , Soleymanpour Ali , Mohammad Kazem , Holakouie-Naieni Kourosh 
Published: June 2017

Abstract
The epidemic of deaths by homicide affects every society around the world and represents a major public health crisis. Detailed information on the characteristics of homicides victims from Islamic countries is limited. This article presents forensic epidemiological data on homicides in Isfahan, Iran, during 2013–2015. Isfahan has a population of more than 5 million and 69,387 deaths with 246 homicides between 2013 and 2015. Most victims were male (73%), between the ages of 15 to 29 years (39.5%), married (54%), and employed (54%). The relationship between the actor and the victims showed that 12% were married, 15% friends, 25% strangers, and 47% others or unknown. The most frequent method of homicides was by stabbing (45%), followed by firearms (23%), strangulation (14%), and blunt force trauma (7%). The top 3 methods among males were stabbing, firearms, and strangulation, whereas among females, it was stabbing, strangulation, and by other methods. There was no significant effect on homicide rates by month, weekday, or temperature. Investigators examining deaths in Muslin countries must understand and adjust for the culture, norms, and religious ideology.
How to Successfully Manage Residual Gallbladders Laparoscopically Following Open Techniques?
Authors: Xu Anan , Hu Hai , Zhao Gang , Jiao Long 
Published: June 2017

Purpose:
This study aimed to explore the feasibility and safety of laparoscopic retreatment for residual gallbladders following open techniques, and outline strategies for successful reintervention.

Patients and Methods:
From January 2008 to December 2015, the clinical and follow-up data of 32 patients who underwent laparoscopic reintervention for residual gallbladders following open techniques were retrospectively analyzed and summarized.

Results:
Of all patients, 4 underwent 2 laparotomic surgeries; 6 had choledocholithiasis and underwent endoscopic retrograde cholangiopancreatography. All procedures for residual gallbladders, except 1, were successfully completed by laparoscopy using 3 to 6 trocars. The mean operative time, mean blood loss, and duration of hospital stay were 51.9±14.6 minutes, 30 mL, and 3 to 8 days, respectively. One patient had bilious drainage, lasting up to day 8. All patients remained symptom free, and no mortality and major morbidity were observed on a mean follow-up of at least 6 months.

Conclusions:
Laparoscopic management is feasible and safe for residual gallbladders following open techniques, subject to availability of expertise with well-defined strategies.
DNA Replication Modulates R-loop Levels to Maintain Genome Stability
Authors: Hamperl Stephan , Saldivar Joshua , Bocek Michael , Cimprich Karlene A. 
Published: June 2017

SummaryConflicts between transcription and replication are a potent source of DNA damage. The transcription machinery has the potential to aggravate such conflicts by generating co-transcriptional R-loops as an additional barrier to replication fork progression. Here, we investigate the influence of conflict orientation and R-loop formation on genome stability in human cells using a defined episomal system. This approach reveals that head-on (HO) and co-directional (CD) conflicts induce distinct DNA damage responses. Unexpectedly, the replisome acts as an orientation-dependent regulator of R-loop levels, reducing R-loops in the CD orientation but promoting their formation in the HO orientation. Replication stress and deregulated origin firing increase the number of HO collisions leading to genome-destabilizing R-loops. Our findings not only uncover an intrinsic function of the replisome in R-loop homeostasis, but also suggest a mechanistic basis for genome instability associated with deregulated DNA replication, which is observed in many disease states, including cancer.
Vertical fit of HR practices and organizational culture: a case of a large-sized Korean conglomerate
Authors: Lee Hwanwoo , Park Joon Hyung , Ngan Shing-Chung , Tian T. Siva 
Published: June 2017

PurposeThe purpose of this paper is to contribute to the human resources (HR) literature by using exploratory network analysis (ENA), a data-driven technique. This technique was employed to discover how the perceived effectiveness of HR practices interrelate with employee perceptions on organizational cultural factors to enhance organizational commitment.Design/methodology/approachThe authors used data from 1,459 employees of a large South Korean conglomerate and studied how individual HR practices could be enhanced by specific organizational cultural factors. The data were analyzed using ENA, which is an inductive approach.FindingsThe authors found that organizational commitment is associated with the positive perceptions of employees on the effectiveness of HR practices, such as performance appraisal, training and development, and compensation. Results show that when both HR practices and organizational cultural factors are considered, they appear to influence organizational commitment independently.Research limitations/implicationsData were collected from a large conglomerate. The authors were limited by the use of the scales developed by a consulting firm. Therefore, readers should be cautious about the generalizability of the findings.Originality/valueThe application of a data-driven technique (ENA) highlights the potentially fertile methodological grounds for HR research. Literature on strategic HR management may benefit from inductive approaches, wherein data serve as primary foundation for the design and development of new theories.
An examination of the moderating effect of electronic-HRM on high-performance work practices and organisational performance link
Authors: Obeidat Shatha M. 
Published: June 2017

PurposeThe purpose of this paper is to examine electronic-HRM (e-HRM) as a contingency factor moderating the relationship between high-performance work practices (HPWP) and organisational performance. It also explores the hypothesised relationship within the Middle Eastern context.Design/methodology/approachAn empirical study was conducted on Jordanian firms operating in both financial and manufacturing sectors. The final research sample consisted of 118 questionnaires. The data were analysed using partial least squares through Smart PLS.FindingsThe findings show support for the hypothesised relationship. In particular, this study shows that both HPWP and e-HRM have a significant positive influence on organisational performance. The results also revealed that e-HRM moderates the HPWP-performance link.Practical implicationsOverall, these findings support previous claims that the adoption of HPWP contributes to organisational success. In particular, firms operating in the Middle Eastern region could improve their performance by implementing HPWP. It also confirms the vital role of e-HRM on improving the positive influence of HPWP on organisational performance. Thus, managers may consider investing in e-HRM system in order to enforce the contribution of HPWP to the effectiveness of their firms.Originality/valueThis study represents a first attempt to measure e-HRM as a possible moderating variable in the HPWP and organisational performance link. Such moderation would be a contribution to the strategic HRM field as very recent research calls for studies that examine new intermediary variables in an attempt to unlock the “black box” in the HPWP and performance link.
Measuring teamwork and team performance in collaborative work environments
Authors: King Kylie Goodell 
Published: June 2017

Purpose
Tasks in today’s global marketplace are becoming increasingly reliant on the work of teams. As creativity and innovation are frequently required for organizational success, work teams are becoming more and more prominent within all types of organizations. With the rise of organizational teams, the purpose of this paper is to develop appropriate tools to measure how well these teams work together and how well they perform required tasks.

Design/methodology/approach
This paper outlines a measure of teamwork, a transactive memory system (TMS), and proposes new methods for using TMSs to measure team structures, processes, and performance. These new methods include dispersion models and social network analysis.

Findings
Dispersion models and social network analysis hold promise for the future evaluation of TMS and other team constructs.

Originality/value
This paper provides a summary of two novel approaches to the measurement of TMS and other team constructs.
A nanotechnology roadmapping study for the Turkish defense industry
Authors: Aydogdu Ayhan , Burmaoglu Serhat , Saritas Ozcan , Cakir Serhat 
Published: June 2017

PurposeTechnologies are constantly developed to address new demands and provide further opportunities. Owing to a number of potential application areas of nanotechnologies within this sector, the purpose of this study is to take defense as a case and propose a strategic roadmap for the use of nanotechnologies in the Turkish Defense Industry.Design/methodology/approachThe study presented in this paper uses a bibliometric analysis of the most cited publications in the past decade with the aim of identifying the trends in the development of nanotechnology. Interviews were carried out with experts based on the featured words of bibliometric analysis (nanoparticles, nanostructure, self-assembly, drug delivery, graphene, etc.) to reveal the commercialization time of nanotechnology products and applications. After that, a survey was carried out with engineers for determining the possible emergence time of nanotechnology applications and/or products used in military up to year 2035. Finally, a roadmap was created based on the obtained data from bibliometric analysis, interviews and survey results.FindingsNanotechnology roadmap was prepared, one which would contribute to the preparation of the defense industry for the future and help in keeping up with technological developments.Research limitations/implicationsBecause of the chosen research approach, the research results may lack generalizability. Therefore, researchers are encouraged to test the proposed propositions further. Interviews and surveys have limitation with the bounded rationality of corresponders.Practical implicationsThe paper proposed a nanotechnology roadmap for the defense sector with a data-led foresight practice.Originality/valuePerforming such a study is considered to be crucial for the armies of developed and developing countries, so that the military sector also avails benefits from this revolutionary technology. Quantitative and qualitative methods were mixed for developing the roadmap.
Using the GM(1,1) model cluster to forecast global oil consumption
Authors: Yuan Chaoqing , Zhu Yuxin , Chen Ding , Liu Sifeng , Fang Zhigeng 
Published: June 2017

Purpose
The purpose of this paper is to compare GM(1,1) model, rolling GM(1,1) model and metabolism GM(1,1) model included in the GM(1,1) model cluster and use these models to forecast global oil consumption.

Design/methodology/approach
Simulated sequences will be generated randomly, and used to test the models included in the GM(1,1) model cluster; and these grey forecasting models are applied to forecast global oil consumption.

Findings
Effectiveness of these grey forecasting models is proved by random experiments, which explains the model adaptability. Global oil consumption is predicted, and it shows that global oil consumption will increase at a rather big growth rate in the next years.

Originality/value
The effectiveness of medium-term prediction of these grey forecasting models is analyzed by random experiments. These models are compared, and some basis for model selection is obtained.