bluuebunny/crossref_metadata_2025_split huggingface dataset:
Особливості парламентського контролю над виконавчою владою в Іспанії
Authors: Годлевська Валентина 
Published: October 2024

The article analyzes the parliamentary control over the executive branch in Spain. The exercise of the control function by the parliament is one of the most important components of its activity. The main purpose of parliamentary control is to identify key problems in the activities of state bodies, increase the efficiency of the public administration system and draw the attention of relevant state bodies and officials to the shortcomings identified during parliamentary control in order to eliminate them.
The main procedures of the Spanish parliament are legislative activity, parliamentary control over the activities of the executive branch, ratification of international treaties, the appointment of national referendums and some others. A study of Spanish constitutional practice and national legislation on the interaction of the legislative and executive branches of government confirms that the mechanism for reviewing the Government’s activities includes two main elements: parliamentary control and the requirement of political accountability of the Government. Parliamentary control is the responsibility of the General Cortes, both chambers, while the requirement of political responsibility is limited to the Congress of Deputies. The lower house of parliament plays a more important role in this process, as it can only implement the requirement of political accountability of the Government. However, the Senate, excluded from the latter, may also exercise control over the Government, using in this case the full range of means provided for in the Spanish constitutional system.
PkM Sosialisasi Pentingnya Konsumsi Makanan Tinggi Zat Besi Untuk Mencegah Anemia Pada Ibu di Desa Sanrobone, Kabupaten Takalar
Authors: Dirgahayu A. Millaty , Hamzah Pratiwi Nasir , Iskandar Darariani 
Published: October 2024

Anemia merupakan salah satu masalah kesehatan masyarakat di Indonesia yang dapat dialami oleh semua kelompok umur mulai dari balita sampai usia lanjut. Berdasarkan data Riskesdas 2018, prevalensi anemia pada remaja berusia 15-24 tahun sebesar 32%, artinya masih terdapat permasalahan anemia di Indonesia yang belum teratasi. Tujuan dari pengabdian masyarakat ini adalah untuk memberikan edukasi mengenai pentingnya konsumsi makanan tinggi zat besi untuk mencegah anemia khususnya bagi Perempuan. Sasaran dari kegiatan pengabdian masyarakat ini adalah Perempuan di wilayah Desa Sanrobone Kabupaten Takalar. Total Perempuan yang mengikuti kegiatan pengabdian masyarakat berjumlah 50 orang. Kegiatan pengabdian masyarakat ini terdiri dari tiga tahapan diantaranya pretest, edukasi dengan banner dan sosialisasi langsung, dan posttest. Jumlah dan jenis pertanyaan pretest dan posttest sama. Jumlah pertanyaan yang diberikan adalah 12 soal. Jawaban yang benar diberikan nilai 10 dan yang salah diberikan nilai 0. Sebagian besar Perempuan berada pada rentang usia 20-45 tahun (74%). Hasil menunjukkan bahwa terdapat peningkatan pengetahuan mengenai anemia dan bahan makanan yang mencegah anemia. Hasil uji Wilcoxon signed rank test menunjukkan hasil pretest dan posttest yang berbeda nyata (p-value = 0,000), sehingga dapat disimpulkan bahwa pemberian sosialisasi dapat membantu meningkatkan pengetahuan tentang pentingnya mengkonsumsi makanan tinggi zat besi untuk mencegah anemia.
Pelatihan Pemasaran Online Pada Toko Persatuan Di Yogyakarta
Authors: Linawati Linawati , Sutrischastini Ary , Sofiati Sofiati 
Published: October 2024

Tujuan Program Pengabdian Kepada Masyarakat (PKM) ini adalah menciptakan pengusaha, pengelola dan karyawan perusahaan (toko) yang memahami tentang pemasaran online dengan memanfaatkan sarana yang dimiliki (handphone android) untuk meningkatkan penjualan dan keuntungan perusahaan secara optimal.Metode perekrutan peserta dilakukan dengan mengambil 1 Toko yaitu Toko Persatuan yang digunakan sebagai sampel yang terdiri dari 1 orang pemilik toko, 1 orang pengelola toko dan 3 orang karyawan. Adapun metode pelatihan yang digunakan dalam Pelatihan Pemasaran Online ini dilakukan dengan 3 tahap yaitu pertama, pembekalan materi secara tutorial dan diskusi tentang pentingnya pemasaran online untuk meningkatkan penjualan dan keuntungan, kedua praktek yang dipandu pengusul dan ketiga adalah monitoring & evaluasi dari kegiatan praktek yang telah dilakukan. Hasil pelaksanaan melalui 3 tahap Program Pelatihan Pemasaran Online ini adalah menghasilkan pengusaha, pengelola dan karyawan perusahaan (toko) yang mempunyai pengetahuan dan memahami tentang pemasaran online khususnya penggunakan handphone android sebagai sarana untuk melakukan kegiatan promosi yang murah, cepat dan tepat di masa sekarang dan di masa mendatang. Kesimpulan pelaksanaan pelatihan berhasil memberikan edukasi pengelola toko maupun karyawan terbukti dari antusiasme mereka selama pelatihan sehingga diharapkan program selanjutnya diusulkan pelatihan masalah manajemen keuangan.
KKN-T UNIRA 14 MENGEMBANGKAN POTENSI DAN KREATIVITAS SANTRI ANTAR TPQ DESA SRIGONCO MELALUI LOMBA FESTIVAL ANAK SHOLEH MILENIAL (SALIM)
Authors: Achadah Alif , Ariska Riris Nur 
Published: October 2024

Srigonco- KKN-T 14 Unira Malang mengadakan lomba festival anak sholeh millenial (salim). Kegiatan tersebut dilakukan guna mengembangkan potensi dan kreativitas santri antar TPQ di desa Srigonco. Kegiatan ini bertempat di Balai Desa Srigonco Bantur Malang. Lomba festival anak sholeh ini diadakan sebagai program kerja terakhir sekaligus puncak kemeriahan acara penutupan dari KKN-T 14 Unira Malang. Antusiasme dari beberapa TPQ di desa Srigonco sangat baik dan acara tersebut sangat diapresiasi oleh Bapak lurah dan Ibu lurah desa Srigonco.
PENANAMAN SERIBU POHON SEBAGAI UPAYA PENGHIJAUAN DAN PELESTARIAN SUMBERMATA AIR DESA SUMBERDEM
Authors: Saepuddin Ahmad 
Published: October 2024

Tujuan kegiatan program pengabdian revitalisasi lahan melalui penanaman seribu pohon sebagai upaya penghijauan dan pelestarian sumbermata air di hutan lindung desa Sumberdem Kecamatan Wonosari Malang adalah untuk 1) meningkatkan dan membentuk kesadaran tentang konservasi sumber daya lahan di lingkungan, 2) meningkatkan pengetahuan tentang manfaat penghijauan dan menjaga lingkungan, dan 3) menumbuhkan rasa memiliki dan berperan dalam menjaga lingkungan melalui gerakan tanam dan pelihara pohon. Tempat kegiatan di Desa Sumberdem, kecamatan Wonosari, kabupaten Malang pada 5 Februari 2023. Mitra dalam kegiatan penanaman seribu pohon adalah pemuda wigati GKJW Sumberdem, karang taruna, dinas kehutanan, dan masyarakat desa Sumberdem. Kegiatan Penanaman seribu pohon meliputi perencanaan penanaman, persiapan penanaman, dan proses penanaman. Kegiatan program pengabdian secara keseluruhan dapat dikatakan baik dan berhasil, berdasarkan pengukuran tiga komponen. Tiga komponen tersebut yaitu kesesuaian dengan keinginan masyarakat, kerjasama pengabdian UNIRA Malang bersama masyarakat, dan Peningkatan pengetahuan masyarakat untuk menjaga lingkungan. Adanya kegiatan tersebut diharapkan ada kesadaran masyarakat akan untuk memelihara lingkungan hidupnya mengingat wilayah penanaman pohon menjadi sumbermata air.
PEMBERDAYAAN WIRAUSAHA PEREMPUAN MELALUI LITERASI DAN INKLUSI KEUANGAN DALAM UPAYA MENDUKUNG PENGEMBANGAN WISATA EDUKASI KAMPUNG NANAS DESA PALAAN
Authors: Ika Ika Rinawati , Yuli Yuliyanti M. Manan, S.EI.,M.SI 
Published: October 2024

UMKM merupakan salah satu kegiatan ekonomi terbesar di Indonesia yaitu sebesar 98% dari total keseluruhan jenis usaha, dari 98% tersebut ternyata 60% adalah ditempati oleh pelaku usaha perempuan. Desa Palaan yang memiliki objek wisata kampung nanas menjadi salah satu alasan kenapa UMKM di Desa tersebut harus berkembang, proses dukungan pengembangan yang bisa diberikan adalah edukasi mengenai literasi dan inklusi keuangan kepada para pelaku usaha perempuan yang tergabung dalam anggota PKK Desa Palaan Kecamatan Ngajum Kabupaten Malang. Strategi yang dilakukan untuk mencapai hasil yang diharapkan dengan menggunakan metode Participatory Action Research (PAR). Metode PAR memiliki tiga variable kunci yaitu, partisipatoris, action (aksi), dan research (penelitian). Hasil kegiatan terdiri dari Peningkatan pemahaman mengenai literasi keuangan dan Peningkatan Pemahaman Mengenai Inklusi Keuangan. Tidak bisa dipungkiri bahwa inklusi keuangan menjadi point penting yang harus dipenuhi oleh para pelaku UMKM karena salah satu faktor pendukung pengembangan suatu bisnis adalah permodalan.
Kata Kunci : Pemberdayaan Perempuan, Wirausaha, Literasi Keuangan, Inklusi Keuangan
Unskilled and unaware? Differences in metacognitive awareness between high and low-ability students in STEM
Authors: Morphew Jason W. 
Published: October 2024

IntroductionMetacognition, or the ability to monitor and control one's cognitive processes, is critical for learning in self-regulated contexts, particularly in introductory STEM courses. The ability to accurately make predictions about one's ability and performance can determine the effectiveness in which students effectively prepare for exams and employ good study strategies. The Dunning-Kruger pattern, where low-performing individuals are more overconfident and less accurate at the ability to predict their performance than high-performing individuals, is robustly found in studies examining metacognitive monitoring. The extent to which the Dunning-Kruger pattern can be explained by the lack of metacognitive awareness is not yet established in the literature. In other words, it is unclear from prior work whether low-performing students are “unskilled and unaware” or simply “unskilled but subjectively aware.” In addition, arguments about whether this pattern is a psychological phenomenon or a statistical artifact of the measurement of metacognition can be found in the literature.MethodsStudents enrolled in three different physics courses made predictions about their exam scores immediately before and after taking each of the three exams in the course. Student predictions were compared to their exam scores to exam metacognitive accuracy. A new method for examining the cause of the Dunning-Kruger effect was tested by examining how students adjust their metacognitive predictions after taking exams.ResultsIn all contexts low-performing students were more overconfident and less accurate at making metacognitive predictions than high-performing students. In addition, these students were less able to efficiently adjust their metacognitive predictions after taking an exam.DiscussionThe results of the study provide evidence for the Dunning-Kruger effect being a psychological phenomenon. In addition, findings from this study align with the position that the skills needed to accurately monitor one's performance are the same as those needed for accurate performance in the first place, thus providing support for the “unskilled and unaware” hypothesis.
The association between pregnancy outcomes and frozen-thawed embryo transfer cycles based on D3 cell count in high-quality blastocysts
Authors: Li Xiang , Zeng Youman , Zhu Lingling , Yang Zengyu , Luo Yudi , Jia Jun-Long 
Published: October 2024

ObjectiveTo investigate the number of cells in D3-stage embryos of high-quality blastocysts as a contributing factor, to evaluate the clinical pregnancy outcomes in frozen-thawed embryo transfer cycles, and to determine the impact of D3-stage cell count on pregnancy outcomes.MethodsPatients under 38 years old who underwent frozen-thawed single high-quality blastocyst transfer at our center were selected. Based on the cell count of D3 cleavage-stage embryos forming blastocysts, patients were divided into three groups: ≤6 cells, 7-9 cells, and ≥10 cells. A multivariate regression analysis was used to establish the prediction model, analyzing the impact of different D3 cleavage-stage cell counts on clinical pregnancy outcomes to guide clinical laboratories in selecting blastocysts with the best pregnancy outcomes for transfer.ResultsThis study identified a significant association between D3 cell count, blastocyst development stage, and embryo age. Embryos with a higher D3 cell count (≥10) were more likely to reach advanced blastocyst stages and form blastocysts by D5, whereas embryos with fewer D3 cells (≤6) were more likely to form blastocysts on D6. While D3 cell count significantly influenced blastocyst stage and timing of embryo development, no significant differences were observed between groups regarding clinical pregnancy, implantation, or live birth rates. Notably, embryos with fewer D3 cells exhibited a significantly lower miscarriage rate than other groups. Multivariate regression analysis showed a significant correlation between blastocyst stage, embryo age, and D3 cell count, particularly in D5 embryos and more advanced blastocysts. The increased miscarriage rate may be related to lower D3 cell count, and inadequate endometrial preparation was associated with poorer pregnancy outcomes. The type of infertility was also linked to D3 cell count, with secondary infertility patients showing more significant influencing factors.ConclusionD3 cell count and related factors play a critical role in pregnancy outcomes during frozen-thawed high-quality blastocyst transfer cycles. Optimizing embryo age, selecting blastocysts at different stages, and refining endometrial preparation protocols are likely to enhance clinical pregnancy and live birth rates.
Mixed comparison of different exercise interventions on physical functioning in adult patients with morbid obesity following bariatric surgery: a systematic review and network meta-analysis
Authors: Hu Chen , Sun Dong , Fang Yufei , Cen Xuanzhen , Xu Yining , Baker Julien S. , Gu Yaodong 
Published: October 2024

IntroductionPeople who are overweight following bariatric surgery (BS) often need physical exercise to help with body function. However, it is not known which exercise interventions are more effective in improving physical function.MethodsPubMed, Web of Science, Embase, and Cochrane Library databases were systematically searched for randomized controlled trials evaluating the effects of different exercise interventions on physical function in patients with excessive obesity following bariatric surgery. Outcome measures included effect sizes for physical function (PF), expressed as the number of stand-sit passes or the maximum distance walked within a time limit, body mass index (BMI), and blood pressure (BP). A systematic review was conducted to screen and synthesize the included studies, followed by a network meta-analysis for quantitative data analysis.ResultsA total of 15 studies involving 1011 patients were included. For PF, telehealth core exercise had the highest probability (0.46) of being the most effective intervention. For BMI, nutritional behavior and guided exercise, intervention had the highest probability (0.27) of being the most effective. Regarding BP, exercise prescription had the highest probability (0.47) for improving systolic blood pressure, while aerobic and strength and flexibility training had the highest probability (0.6) for improving diastolic blood pressure.DiscussionTelehealth core exercise may be the most effective intervention for enhancing PF in overweight patients after bariatric surgery. Changes in BMI and BP with different postoperative exercise interventions may depend more on the surgery itself than the exercise modality. More specifically designed RCTs are needed for reliable conclusions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024507209.
Integrated temporal transcriptional and epigenetic single-cell analysis reveals the intrarenal immune characteristics in an early-stage model of IgA nephropathy during its acute injury
Authors: Xu Chen , Zhang Yiwei , Zhou Jian , Zhang Jiangnan , Dong Hui , Chen Xiangmei , Tian Yi , Wu Yuzhang 
Published: October 2024

RationaleKidney inflammation plays a crucial role in the pathogenesis of IgA nephropathy (IgAN), yet the specific phenotypes of immune cells involved in disease progression remain incompletely understood. Utilizing joint profiling through longitudinal single-cell RNA-sequencing (scRNAseq) and single-cell assay for transposase-accessible chromatin sequencing (scATACseq) can provide a comprehensive framework for elucidating the development of cell subset diversity and how chromatin accessibility regulates transcription.ObjectiveWe aimed to characterize the dynamic immune cellular landscape at a high resolution in an early IgAN mouse model with acute kidney injury (AKI).Methods and resultsA murine model was utilized to mimic 3 immunological states –”immune stability (IS), immune activation (IA) and immune remission (IR)” in early human IgAN-associated glomerulopathy during AKI, achieved through lipopolysaccharide (LPS) injection. Urinary albumin to creatinine ratio (UACR) was measured to further validate the exacerbation and resolution of kidney inflammation during this course. Paired scRNAseq and scATACseq analysis was performed on CD45+ immune cells isolated from kidney tissues obtained from CTRL (healthy vehicle), IS, IA and IR (4 or 5 mice each). The analyses revealed 7 major cell types and 24 clusters based on 72304 single-cell transcriptomes, allowing for the identification and characterization of various immune cell types within each cluster. Our data offer an impartial depiction of the immunological characteristics, as the proportions of immune cell types fluctuated throughout different stages of the disease. Specifically, these analyses also revealed novel subpopulations, such as a macrophage subset (Nlrp1b Mac) with distinct epigenetic features and a unique transcription factor motif profile, potentially exerting immunoregulatory effects, as well as an early subset of Tex distinguished by their effector and cytolytic potential (CX3CR1-transTeff). Furthermore, in order to investigate the potential interaction between immune cells and renal resident cells, we conducted single-cell RNA sequencing on kidney cells obtained from a separate cohort of IS and IA mice without isolating immune cells. These findings underscored the diverse roles played by macrophages and CD8+ T cells in maintaining homeostasis of endothelial cells (ECs) under stress.ConclusionsThis study presents a comprehensive analysis of the dynamic changes in immune cell profiles in a model of IgAN, identifying key cell types and their roles and interactions. These findings significantly contribute to the understanding of the pathogenesis of IgAN and may provide potential targets for therapeutic intervention.
Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties
Authors: Georgaki Galateia , Mpakali Anastasia , Trakada Myrto , Papakyriakou Athanasios , Stratikos Efstratios 
Published: October 2024

IntroductionER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.MethodsTo understand the molecular mechanisms that underlie the biology of allotype 10, we studied its enzymatic and biophysical properties focusing on its unique polymorphisms V349M and Q725R.ResultsCompared to ancestral allotype 1, allotype 10 is much less effective in trimming small substrates but presents allosteric kinetics that ameliorate activity differences at high substrate concentrations. Furthermore, it is inhibited by a transition-state analogue via a non-competitive mechanism and is much less responsive to an allosteric small-molecule modulator. It also presents opposite enthalpy, entropy, and heat capacity of activation compared to allotype 1, and its catalytic rate is highly dependent on viscosity. Polymorphisms V349M and Q725R significantly contribute to the lower enzymatic activity of allotype 10 for small substrates, especially at high substrate concentrations, influence the cooperation between the regulatory and active sites, and regulate viscosity dependence, likely by limiting product release.ConclusionsOverall, our results suggest that allotype 10 is not just an inactive variant of ERAP1 but rather carries distinct enzymatic properties that largely stem from changes at positions 349 and 725. These changes affect kinetic and thermodynamic parameters that likely control rate-limiting steps in the catalytic cycle, resulting in an enzyme optimized for sparing small substrates and contributing to the homeostasis of antigenic epitopes in the ER.
Serum and mucosal antibody-mediated protection and identification of asymptomatic respiratory syncytial virus infection in community-dwelling older adults in Europe
Authors: Öner Deniz , Vernhes Charlotte , Balla-Jhagjhoorsingh Sunita , Moureau Annick , Crabbe Marjolein , Salaun Bruno , Bastian Arangassery Rosemary , Thys Kim , De Smedt Jonathan , Ooft Salo N. , Korsten Koos , Adriaenssens Niels , Coenen Samuel , Butler Christopher C. , Verheij Theo J. M. , Drysdale Simon B. , Wildenbeest Joanne G. , Pollard Andrew J. , Openshaw Peter J. M. , Bont Louis , Aerssens Jeroen 
Published: October 2024

IntroductionRespiratory syncytial virus (RSV) causes acute respiratory tract infection (ARTI) and reinfects adults throughout life, posing a risk for hospitalization in older adults (&gt;60 years) with frailty and comorbidities.MethodsTo investigate serum and mucosal antibodies for protection against RSV infections, baseline serum samples were compared for RSV-pre- and -post-fusion (F) binding, and RSV-A2 neutralizing IgG antibodies between symptomatic RSV-ARTI (N = 30), non-RSV (RSV negative) ARTI (N = 386), and no ARTI (N = 338). Mucosal RSV-pre-F IgA and IgG levels, as well as serum RSV-G IgG antibodies, were analyzed to determine their association with protection from symptomatic RSV-ARTI in a subset study.ResultsUsing a receiver operating characteristic (ROC) analysis, we established thresholds of 1.4- to 1.6-fold change (FC) for RSV-pre-F and -post-F, and RSV-A2 neutralizing IgG antibodies, respectively, enabling the identification of asymptomatic RSV cases with high sensitivity and specificity (&gt;80% and &gt;90%, respectively). As a result, serum RSV-pre-F, RSV-G IgG, and mucosal pre-F binding IgA antibodies showed correlations with protection against symptomatic RSV infection. RSV-pre-F IgG antibodies were correlated with protection from RSV infections irrespective of the symptoms.DiscussionThis study provides insights into antibody-mediated protection for symptomatic RSV infection in a community-dwelling older-adult population and establishes a threshold to identify asymptomatic RSV infection using a data-driven approach.