bluuebunny/crossref_metadata_2025_split huggingface dataset:
Task-State Functional MRI of Brain Regions with Reduced Activation in Aphasia Patients: A Meta-analysis
Authors: Yu Xin-ming , Lv Wen-ming , Yu Qiao-wen , Kang Xi-zhi , Liu Xiao-liang , Zhang Liang-wen 
Published: October 2024

ABSTRACT

Objective:
Language is one of the most celebrated hallmarks of human cognition. With the continuous improvement of medical technology, functional MRI (fMRI) has been used in aphasia. Although many related studies have been carried out, most studies have not extensively focused on brain regions with reduced activation in aphasic patients. The aim of this study was to identify brain regions normally activated in healthy controls but with reduced activation in aphasic patients during fMRI language tasks.

Methods:
We collected all previous task-state fMRI studies of secondary aphasia. The brain regions showed normal activation in healthy controls and reduced activation in aphasic patients were conducted activation likelihood estimation (ALE) meta-analysis to obtain the brain regions with consistently reduced activation in aphasic patients.

Results:
The ALE meta-analysis revealed that the left inferior frontal gyrus, left middle temporal gyrus, left superior temporal gyrus, left fusiform gyrus, left lentiform nucleus and the culmen of the cerebellum were the brain regions with reduced activation in aphasic patients.

Discussion:
These findings from the ALE meta-analysis have significant implications for understanding the language network and the potential for recovery of language functions in individuals with aphasia.
Reduced basal motion responsible for 50 years of declining ice velocities on Athabasca Glacier
Authors: Polashenski David , Truffer Martin , Armstrong William Henry 
Published: October 2024

Abstract
The time-evolution of glacier basal motion remains poorly constrained, despite its importance in understanding the response of glaciers to climate warming. Athabasca Glacier provides an ideal site for observing changes in basal motion over long timescales. Studies from the 1960s provide an in situ baseline dataset constraining ice deformation and basal motion. We use two complementary numerical flow models to investigate changes along a well-studied transverse profile and throughout a larger study area. A cross-sectional flow model allows us to calculate transverse englacial velocity fields to simulate modern and historical conditions. We subsequently use a 3-D numerical ice flow model, Icepack, to estimate changes in basal friction by inverting known surface velocities. Our results reproduce observed velocities well using standard values for flow parameters. They show that basal motion declined significantly (30–40%) and this constitutes the majority (50–80%) of the observed decrease in surface velocities. At the same time, basal resistive stress has remained nearly constant and now balances a much larger fraction of the driving stress. The decline in basal motion over multiple decades of climate warming could serve as a stabilizing feedback mechanism, slowing ice transport to lower elevations, and therefore moderating future mass loss rates.
A limited case for the closed material procedure: natural justice, open justice and the clear advantage variation
Authors: Lui Edward 
Published: October 2024

AbstractThe closed material procedure (CMP) – ever since its introduction to English law – has been subjected to a very significant amount of academic criticism. But over time, the CMP has become increasingly settled as a fixture in English law. Whilst the existence of the CMP per se in English law seems settled, the extent of its deployment is not. Given this development, it seems important and constructive to examine whether – and the conditions under which – a CMP can ever be normatively justified, all things considered. Two propositions will be made. First, a common argument for the CMP – the maximising argument – does not demonstrate that the CMP is normatively justified, all things considered, for it does not sufficiently mitigate the two main objections to the CMP, based respectively on the principles of natural justice and open justice. Secondly, where the clear advantage variation is deployed – ie when a CMP allows the excluded party to make use of material that: (a) clearly advantages him; and (b) would otherwise be unavailable for the court's consideration – both objections are sufficiently mitigated. In such a case, the CMP is normatively justified, all things considered. This constitutes a limited normative case for the CMP.
Frailty, Body Composition, and Glycemic Control in Older Adults with Type 2 Diabetes
Authors: Madden Kenneth M. , Feldman Boris , Sy Sarah , Meneilly Graydon S. 
Published: October 2024

Abstract
The relationship between frailty and glycemic control in older adults with diabetes remains uncertain, mainly due to the fact that previous studies have not accounted for measures of body composition. In older adults with diabetes, we examined the association between three types of frailty measures and glycemic control, while accounting for fat-free mass (FFM) and waist circumference (WC). Eighty older adults (age ≥65, 27 women and 53 men, mean age 80.5 ± 0.6 years) had gait speed, Cardiovascular Health Study Index (CHSI), Rockwood Clinical Frailty Scale (RCFS), and glycosylated hemoglobin (HgA1C) measured. HgA1C showed a negative association only with CHSI (standardized β = −0.255 ± 0.120, p = 0.038), but no association with gait speed or the RCFS. Even after accounting for FFM and WC, we demonstrated a negative association between glycated hemoglobin and increasing frailty in older adults with diabetes.
What does it take for healthy food retail programmes to be successful? Lessons learned in New York City
Authors: Setiono Felicia J , Heller Samantha P , Leak Tashara M 
Published: October 2024

Abstract

Objective:
Healthy food retail programmes (HFRP) in the USA generally aim to increase healthy foods access to improve diet quality and health, yet the impact is mixed. These programmes primarily target adults, even though adolescents frequently and independently visit stores to purchase snacks. This study’s aims are to explore successes and challenges of implementing HFRP (Aim 1) and examine how HFRP can be tailored to adolescents (Aim 2).

Design:
One-time, virtual, semi-structured interviews with individuals who were involved in a HFRP, followed by a socio-demographic characteristics survey. Interviews were designed based on the RE-AIM framework and the Hexagon Tool and analysed using Braun and Clark’s (2006) thematic analysis approach. Descriptive statistics were used to summarise participants’ socio-demographic characteristics.

Setting:
New York City (NYC).

Participants:
Adults (18 years or older) who have designed, implemented and/or evaluated an HFRP in NYC and speak/understand English (n 21).

Results:
Aim 1: For successes, strategies to build relationships with the community were most discussed. Regarding challenges, securing reliable funding was the hardest to overcome. Suggested solutions included designing profitable HFRP, targeting shortcomings in food distribution systems and increasing consumer demand. Aim 2: Most participants had not considered adolescents in previous HFRP but suggested involving youth in developing HFRP to encourage youth-driven solutions and promote youth advocacy.

Conclusions:
Future HFRP should focus on activities that help store owners purchase affordable healthy foods from distributors, which translates to affordability for customers. Federal and local policies can assist by funding complementary programmes. Additionally, adolescents should be considered in these efforts.
Differences in service utilization between pediatric and adult palliative care services in a single center
Authors: Fried Iris , Shaulov Adir , Revel-Vilk Shoshana , Siedner-Weintraub Yael 
Published: October 2024

AbstractObjectivesCurrent recommendations do not separate adult and pediatric palliative care (PC) in terms of the personnel needed, or the distribution of care between community and hospital-based services. We evaluated the differences in the utilization of pediatric and adult hospital PC services for non-oncological patients.MethodsRetrospective study. Parameters included demographics, underlying diagnoses, number of consultations per patient, duration of PC involvement, and follow-up. All non-oncology patients seen by the adult or pediatric PC teams between June 2021 and July 2023 at a single tertiary hospital.ResultsA total of 445 adults and 48 children were seen by the adult and pediatric palliative teams, respectively. Adults were primarily seen in the terminal stages of common chronic diseases, with a high mortality rate. Children were mainly seen at a very young age with rare and complicated diseases. Children needed longer duration of follow-up (114 vs. 5 days, p < 0.001), more consultations (8.5 vs. 4, p < 0.001), and died less while hospitalized (25% of patients vs. 61.6%, p < 0.001).Significance of resultsAdult patients had relatively common diseases, seen and treated often by primary care practitioners, whereas children had rare life-limiting diseases, which primary care pediatricians may have limited experience with, and which require involvement of multiple specialized hospital-based services. Future healthcare PC planning should consider these factors in planning the primary setting for PC teams, specifically more training of adult general practitioners in PC skills, and earlier referral of pediatric patients to hospital-based PC.
Division on the Christian right: Republican pastors and the use of force
Authors: Shady Stephanie N. , Hooghe Liesbet , Marks Gary 
Published: October 2024

AbstractPolarization in American politics has not produced unity among conservative Christians. Drawing from original survey and interview data on Republican pastors in North Carolina, this paper seeks to understand why these pastors are divided on the legitimacy of force defending the “traditional American way of life.” We find (1) that theological fundamentalism has a positive, though weak, influence; (2) Christian nationalism and White grievance are powerful in increasing support for the use of force; and (3) distrust of elections intensifies the effect of these attitudes.
Bibliometric analysis of the inflammation expression after spinal cord injury: current research status and emerging frontiers
Authors: Li Xiaoyu , Jiao Kun , Liu Chen , Li Xiongfei , Wang Shanhe , Tao Ye , Cheng Yajun , Zhou Xiaoyi , Wei Xianzhao , Li Ming 
Published: October 2024

Abstract
Study design
Bibliometric analysis.

Objective
To analyze literature on inflammatory expression following spinal cord injury, highlighting development trends, current research status, and potential emerging frontiers.

Setting
Not applicable.

Methods
Articles were retrieved using terms related to spinal cord injury and inflammatory responses from the Web of Science Core Collection, covering January 1, 1980, to May 23, 2024. Tools like CiteSpace and VOSviewer assessed the research landscape, evaluating core authors, journals, and contributing countries. Keyword co-occurrence analyses identified research trends.

Results
A total of 2504 articles were retrieved, showing a consistent increase in publications. The Journal of Neurotrauma had the highest publication volume and influence. The most prolific author was Cuzzocrea S, with Popovich PG having the highest H-index. China led in the number of publications, followed closely by the United States, which had the highest impact and extensive international collaboration. Research mainly focused on nerve function recovery, glial scar formation, and oxidative stress. Future research is expected to investigate cellular autophagy, vesicular transport, and related signaling pathways.

Conclusion
The growing interest in inflammation caused by spinal cord injury is evident, with current research focusing on oxidative stress, glial scar, and neurological recovery. Future directions include exploring autophagy and extracellular vesicles for new therapies. Interdisciplinary research and extensive clinical trials are essential for validating new treatments. Biomarker discovery is crucial for diagnosis and monitoring, while understanding autophagy and signaling pathways is vital for drug development. Global cooperation is needed to accelerate the application of scientific findings, improving spinal cord injury treatment.
Equity and timeliness as factors in the effectiveness of an ethical prenatal sequencing service: reflections from parents and professionals
Authors: Peter Michelle , Hill Melissa , Fisher Jane , Daniel Morgan , McInnes-Dean Hannah , Mellis Rhiannon , Walton Holly , Lafarge Caroline , Leeson-Beevers Kerry , Peet Sophie , Tapon Dagmar , Wynn Sarah L. , Chitty Lyn S. , Parker Michael 
Published: October 2024

AbstractPrenatal sequencing tests are being introduced into clinical practice in many developed countries. In part due to its greater ability to detect genetic variation, offering prenatal sequencing can present ethical challenges. Here we review ethical issues arising following the implementation of prenatal sequencing in the English National Health Service (NHS). We analysed semi structured interviews conducted with 48 parents offered prenatal sequencing and 63 health professionals involved in delivering the service to identify the ethical issues raised. Two main themes were identified: (1) Equity of access (including issues around eligibility criteria, laboratory analytical processes, awareness and education of clinicians, fear of litigation, geography, parental travel costs, and access to private healthcare), and (2) Timeliness and its impact on parental decision-making in pregnancy (in the context of the law around termination of pregnancy, decision-making in the absence of prenatal sequencing results, and the “importance” of prenatal sequencing results). Recognising both the practical and systemic ethical issues that arise out of delivering a national prenatal sequencing service is crucial. Although specific to the English context, many of the issues we identified are applicable to prenatal sequencing services more broadly. Education of health professionals and parents will help to mitigate some of these ethical issues.
Maintaining and updating accurate internal representations of continuous variables with a handful of neurons
Authors: Noorman Marcella , Hulse Brad K. , Jayaraman Vivek , Romani Sandro , Hermundstad Ann M. 
Published: October 2024

AbstractMany animals rely on persistent internal representations of continuous variables for working memory, navigation, and motor control. Existing theories typically assume that large networks of neurons are required to maintain such representations accurately; networks with few neurons are thought to generate discrete representations. However, analysis of two-photon calcium imaging data from tethered flies walking in darkness suggests that their small head-direction system can maintain a surprisingly continuous and accurate representation. We thus ask whether it is possible for a small network to generate a continuous, rather than discrete, representation of such a variable. We show analytically that even very small networks can be tuned to maintain continuous internal representations, but this comes at the cost of sensitivity to noise and variations in tuning. This work expands the computational repertoire of small networks, and raises the possibility that larger networks could represent more and higher-dimensional variables than previously thought.
Experimental investigation of a nano coating efficiency for dust mitigation on photovoltaic panels in harsh climatic conditions
Authors: Ahmed Asmaa , Elsakka Mohamed , Elhenawy Yasser , Amer Ahmed , Mansi Amr , Bassyouni Mohamed , Gadalla Mamdouh , Refaat Ahmed 
Published: October 2024

AbstractDust accumulation on photovoltaic (PV) panels in arid regions diminishes solar energy absorption and panel efficiency. In this study, the effectiveness of a self-cleaning nano-coating thin film is evaluated in reducing dust accumulation and improving PV Panel efficiency. Surface morphology and elemental analysis of the nano-coating and dust are conducted. Continuous measurements of solar irradiances and ambient temperature have been recorded. SEM analysis of dust revealed irregularly shaped micron-sized particles with potential adhesive properties, causing shading effects on the PV panel surface. Conversely, the coating particles exhibited a uniform, spherical shape, suggesting effective prevention of dust adhesion. Solar irradiance ranged from 120 W/m² to a peak of 720 W/m² at noon. Application of the self-cleaning nano-coating thin film consistently increased short circuit current (Isc), with the coated panel averaging 2.8 A, which is 64.7% higher than the uncoated panel’s 1.7 A. The power output of the coated panel ranged from 7 W to 38 W, with an average of approximately 24.75 W, whereas the uncoated panel exhibited a power output between 3 W and 23 W, averaging around 14 W. These findings highlight the substantial potential of nano-coating for effective dust mitigation, particularly in dusty environments, thus enhancing PV system reliability.
Improved yolov5 algorithm combined with depth camera and embedded system for blind indoor visual assistance
Authors: Zhang Kaikai , Wang Yanyan , Shi Shengzhe , Wang Qingqing , Wang Chun , Liu Sheng 
Published: October 2024

AbstractTo assist the visually impaired in their daily lives and solve the problems associated with poor portability, high hardware costs, and environmental susceptibility of indoor object-finding aids for the visually impaired, an improved YOLOv5 algorithm was proposed. It was combined with a RealSense D435i depth camera and a voice system to realise an indoor object-finding device for the visually impaired using a Raspberry Pi 4 B device as its core. The algorithm uses GhostNet instead of the YOLOv5s backbone network to reduce the number of parameters and computation of the model, incorporates an attention mechanism (coordinate attention), and replaces the YOLOv5 neck network with a bidirectional feature pyramid network to enhance feature extraction. Compared to the YOLOv5 model, the model size was reduced by 42.4%, number of parameters was reduced by 47.9%, and recall rate increased by 1.2% with the same precision. This study applied the improved YOLOv5 algorithm to an indoor object-finding device for the visually impaired, where the searched object was input by voice, and the RealSense D435i was used to acquire RGB and depth images to realize the detection and ranging of the object, broadcast the specific distance of the target object by voice, and assist the visually impaired in finding the object.
Estrogen-stimulated uropathogenic E. coli mediate enhanced neutrophil responses
Authors: Pettersson Carolina , Wu Rongrong , Demirel Isak 
Published: October 2024

AbstractUrinary tract infection (UTI) is one of the most common bacterial infections worldwide and the most common cause is uropathogenic Escherichia coli (UPEC). Current research is mostly focused on how UPEC affects host factors, whereas the effect of host factors on UPEC is less studied. Our previous studies have shown that estrogen alters UPEC virulence. However, the effect of this altered UPEC virulence on neutrophils is unknown. The aim of the present study was to investigate how the altered UPEC virulence mediated by estrogen modulates neutrophil responses. We found that estradiol-stimulated CFT073 increased neutrophil phagocytosis, NETs formation and intracellular ROS production. We observed that the total ROS production from neutrophils was reduced by estradiol-stimulated CFT073. We also found that estradiol-stimulated CFT073 induced less cytotoxicity in neutrophils. Additionally, we found that several cytokines and chemokines like IL-8, IL-1β, CXCL6, MCP-1 and MCP-4 were increased upon estradiol-stimulated CFT073 infection. In conclusion, this study demonstrates that the estrogen-mediated alterations to UPEC virulence modulates neutrophil responses, most likely in a host-beneficial manner.
The Lumbar Artery Perforator Free Flap as an Alternative Option for Breast Reconstruction in Low BMI Patients: Analysis of CT Angiography of Donor Sites Across BMI
Authors: Casey Máire-Caitlin , Hurley Anna R. , Chrysopoulo Minas , Khan Aadil Ali , Power Kieran , Nanidis Theodore 
Published: October 2024

Abstract
Background In patients with a low body mass index (BMI), the options for autologous breast reconstruction are limited. With the hypothesis that adipose tissue deposition favors the lumbar region over the abdominal wall, this study sought to investigate the lumbar artery perforator (LAP) flap as an alternative reconstructive option in patients with deficient autologous donor sites consequent to a low BMI.
Methods A retrospective cohort analysis was performed, from a prospectively maintained database, of all consecutive deep inferior epigastric artery perforator flap breast reconstructions performed in our unit. A randomized selection of 100 patients with low BMI < 22, normal BMI 22 to 24, and high BMI > 30 was performed. Patient computerized tomography scans were analyzed to measure abdominal wall and lumbar tissue thickness and to define anatomical landmark relations of the LAP.
Results A statistically significant difference was identified between the ratio of lumbar-to-abdominal wall thickness between BMI groups, highlighting preservation of the lumbar thickness in patients with low BMI. The mean distance at which the fourth lumbar perforator entered the subcutaneous tissues was 7.7 cm lateral to the spinous process (range 6.4–9.5 cm), with no significant difference between BMI groups, highlighting this consistent anatomical position.
Conclusion This study confirms a greater lumbar-to-abdominal wall thickness, therefore volume, in low BMI patients, with consistent lumbar perforator anatomy of 6.4 to 9.5 cm lateral to the spinous process. The LAP flap should therefore be strongly considered for autologous breast reconstruction in this patient cohort.
Discourse-Level Communication Success in Aphasia: Unveiling Its Significance through Observer's Ratings
Authors: Ramage Amy E. , Rowe Abigail L. , Greenslade Kathryn J. 
Published: October 2024

AbstractAudrey Holland (1982) compared test scores to observers' ratings of conversational communicative success in people with aphasia (PWA). This springboarded a body of evidence employing observers to rate discourse. We review the utility of those ratings for assessing PWA's communication success. A traditional literature review identified 16 articles involving naive or trained raters assessing PWAs' communicative success across discourse genres. Another 10 articles reported ratings over time. Collectively, these studies evaluated 349 PWAs. Four studies utilized observers to rate the success of PWA's conversations. Eight studies that reported observers' ratings on other discourse genres found that multimodal communication and facilitative contexts improved success, and ratings of informativeness and comfort related to objective discourse analysis measures. Nine of 10 studies examining treatment effects found that communicative success ratings captured improvements. Observers' ratings provide social validity by reliably assessing the discourse-level communicative success of PWA. Ratings correlated with standardized diagnostic and objective discourse metrics but provided a window into factors that affect communicative success, including the degree to which communication is interactive, multimodal, and contextual. Integrating observers' ratings of discourse success at pretreatment may help identify supports or barriers to successful communication, facilitate individualization of treatments, and offer social validity of change.