bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentially inappropriate medication use in elderly non‐Hodgkin lymphoma patients is associated with reduced survival and increased toxicities
Authors: Lin Richard J. , Ma Helen , Guo Robin , Troxel Andrea B. , Diefenbach Catherine S. 
Published: November 2017

SummarySurvival outcomes for elderly lymphoma patients are disproportionally inferior to those of younger patients. We examined medication usage at diagnosis for 171 elderly patients (median age 70 years) with aggressive non‐Hodgkin lymphoma treated between 2009 and 2014. At least one potentially inappropriate medication was used in 47% of patients according to the Beers Criteria, 59% experienced treatment delays and/or dose reduction and 65% experienced ≥ grade 3 treatment‐related toxicities. We report here for the first time that potentially inappropriate medication use was associated with reduced progression‐free survival and overall survival, and increased ≥ grade 3 treatment‐related toxicities in multivariate analysis.
Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases
Authors: Dharma C. , Lefebvre D. L. , Tran M. M. , Lou W. Y. W. , Subbarao P. , Becker A. B. , Mandhane P. J. , Turvey S. E. , Sears M. R. ,   the CHILD Study investigators
Published: November 2017

SummaryBackgroundWhile allergic sensitization and atopic dermatitis (AD) are known to increase the risk for allergic diseases, the impact of different temporal and clinical patterns of sensitization and AD is less well defined.ObjectiveWe investigated patterns of sensitization and AD from early infancy to age 3, and the differential risk of developing allergic diseases within each pattern in a general cohort.MethodsChildren (n = 2629) from the Canadian Healthy Infant Longitudinal Development (CHILD) Study underwent skin prick tests and were assessed clinically for AD at ages 1 and 3 years. We applied an unsupervised latent class analysis (LCA) to the following 5 factors at these ages: AD, food sensitization, inhalant sensitization, poly‐sensitization to foods and poly‐sensitization to inhalants. The risks for developing asthma, allergic rhinitis and food allergy at 3 years were evaluated for each identified group.ResultsFive distinct classes were revealed by LCA: healthy (81.8%), atopic dermatitis (7.6%), inhalant sensitization (3.5%), transient sensitization (4.1%) and persistent sensitization (3.2%). Using healthy children as the baseline, children in the “atopic dermatitis” group had the next lowest risk for all allergic outcomes at 3 years; those in the “inhalant sensitization” group had the highest risk for allergic rhinitis; children in the “transient sensitization” group were at an increased risk for food allergy; while children in the “persistent sensitization” group had the highest risk for all allergic diseases.Conclusion and Clinical RelevanceThere is substantial heterogeneity among allergen‐sensitized children. Researchers and clinicians need to be aware of the non‐specificity associated with labelling children simply as “atopic” and “non‐atopic” without considering the timing of their atopic history, type of sensitization and AD status. Children with AD who were poly‐sensitized to foods at an early age appear to be at greatest risk of developing other allergic diseases.
Anti‐Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome
Authors: Sathyapalan Thozhukat , Al‐Qaissi Ahmed , Kilpatrick Eric S. , Dargham Soha R. , Atkin Stephen L. 
Published: November 2017

SummaryObjectiveAnti‐Müllerian hormone (AMH) is derived from the small antral follicles, and an elevated level has been suggested to add value to the Rotterdam criteria for the diagnosis of PCOS in cases of diagnostic uncertainty. Therefore, the role of AMH in the classical phenotype of PCOS was defined within a Caucasian population.DesignThis was a cross‐sectional study.PatientsSixty Five women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria.MeasurementsThe main outcomes were the utility of serum AMH for the diagnosis of PCOS and its relationship to the metabolic parameters.ResultsAnti‐Müllerian hormone was increased in PCOS compared to controls (P < .001). Areas under the receiver operator curve showed AMH to be predictive of PCOS (0.76) using a cut‐off AMH of 46 pmol/L, which is derived from the 95th percentile of the controls that gave a 41% sensitivity and 86% specificity; an AMH cut‐off of 35 pmol/L gave a 55% sensitivity and 79% specificity. Age‐ and BMI‐adjusted multiple logistic regression showed that AMH was more predictive of PCOS independently of either serum testosterone (T) (OR = 4.04; 95% CI 1.42‐11.11; P = .007) or free androgen index (FAI) (OR = 3.90; 95% CI 1.40‐10.83; P = .009).ConclusionWhilst an elevated AMH has poor sensitivity, it is fourfold more likely to be associated with a diagnosis of PCOS, and supplementary to biochemical parameters will make a positive diagnosis of PCOS in 22% of patients when neither serum testosterone nor FAI is elevated.
Advances in chronic cerebral circulation insufficiency
Authors: Zhou Da , Meng Ran , Li Si‐Jie , Ya Jing‐Yuan , Ding Jia‐Yue , Shang Shu‐Ling , Ding Yu‐Chuan , Ji Xun‐Ming 
Published: November 2017

SummaryChronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long‐term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress ofCCCI, mainly focusing on epidemiology, experimental research, pathophysiology, etiology, clinical manifestations, imaging presentation, diagnosis, and potential therapeutic regimens. Some research directions are briefly discussed as well.
Heart rate variability and implication for sport concussion
Authors: Bishop Scott A. , Dech Ryan T. , Guzik Przemyslaw , Neary J. Patrick 
Published: November 2017

SummaryFinding sensitive and specific markers for sports‐related concussion is both challenging and clinically important. Such biomarkers might be helpful in the management of patients with concussion (i.e. diagnosis, monitoring and risk prediction). Among many parameters, blood flow–pressure metrics and heart rate variability (HRV) have been used to gauge concussion outcomes. Reports on the relation betweenHRVand both acute and prolonged concussion recovery are conflicting. While some authors report on differences in the low‐frequency (LF) component ofHRVduring postural manipulations and postexercise conditions, others observe no significant differences in variousHRVmeasures. Despite the early success of using theHRV LFfor concussion recovery, the interpretation of theLFis debated. Recent research suggests theLFpower is a net effect of several intrinsic modulatory factors from both sympathetic and parasympathetic branches of the autonomic nervous system, vagally mediated baroreflex and even some respiratory influences at lower respiratory rate. There are only a few well‐controlled concussion studies that specifically examine the contribution of the autonomic nervous system branches withHRVfor concussion management. This study reviews the most recentHRV– concussion literature and the underlyingHRVphysiology. It also highlights cerebral blood flow studies related to concussion and the importance of multimodal assessment of various biological signals. It is hoped that a better understanding of the physiology behindHRVmight generate cost‐effective, repeatable and reliable protocols, all of which will improve the interpretation ofHRVthroughout concussion recovery.
Stanley Kubrick in the Museum: Post‐cinematic Conditions, Limitations, and Possibilities
Authors: Kim Jihoon 
Published: November 2017

AbstractThis paper contextualizes the Stanley Kubrick exhibition, a worldwide exhibition tour program dedicated to showcasing the complete oeuvre of the filmmaker Stanley Kubrick, within ‘post‐cinematic’ conditions. Since the mid‐1990s, the formal and experiential components of the cinema in the 20th century have increasingly become displaced from the traditional apparatus and site and ‘relocated’ within new technological and institutional platforms, and museums have become one of those new sites for content consumption. The paper discusses both the limitations and possibilities of the exhibition as it is considered to represent the migration of cinema into the art museum context as one salient phenomenon of post‐cinematic conditions. The Kubrick exhibition is explored to uncover the underlying tensions of the ‘exhibition of cinema’ as a key trend of major international museums, between the movie theater as black box and the art museum's exhibition space as white cube. It considers the difference between these two institutional platforms and their conceptions of objecthood, artifact and the temporal economy of the viewing experience. The author argues that this event succeeds in realizing the possibilities for revivifying three constants of cinema: film auteur, cinematic apparatus, and intermediality. The ambivalence demonstrates that while the museum's exhibition of cinema inevitably removes some of its ontological essences, it also preserves and revivifies others.
Location Determinants of China's Outward Foreign Direct Investment
Authors: Yao Shujie , Zhang Fan , Wang Pan , Luo Dan 
Published: November 2017

AbstractCompared to inward foreign direct investment, outward foreign direct investment (OFDI) from China is a relatively new phenomenon. However, the volume of China's OFDI increased rapidly from 2004. There has been an increasing amount of literature on the motivations of China's OFDI, but few studies have focused on its location determinants. The present paper aims to fill this gap in the literature by focusing on two important location factors, natural resources and technology, which are the most important determinants of China's OFDI. We use a large panel dataset comprising 132 countries over the period 1991–2009 and the Tobit as well as the Heckman models to establish the relationship between the two location factors and China's OFDI. The empirical results suggest that although China's OFDI has been driven by the country's desire for a secure supply of natural resources and to attain advanced technology from the developed world, China's technology is also a critical attraction for the host developing economies.
China's Path to Overcoming the Double Middle‐income Traps
Authors: Li Peilin 
Published: November 2017

AbstractChina is at a crucial stage of overcoming the middle‐income trap, with the factors that drive economic growth having undergone significant changes, and domestic consumption playing a more important role in economic growth. It is necessary, at this point, to promote mass consumption by expanding the middle‐income group. The present paper puts forward the concept of the “double middle‐income traps.” This refers to the situation in which an economy's per capita output stagnates and the size of the middle‐income group is unable to expand for an extended period of time. These two factors are closely related. Based on data from the Chinese Social Survey conducted by the Institute of Sociology at the Chinese Academy of Social Sciences, the present paper analyzes the scale and development of middle‐income groups, and the relationship among middle‐income groups, the middle‐class and middle‐class identity. The marginal consumption propensities of middle‐income groups are also considered. The findings of the paper indicate that the expansion of the middle‐income group plays an important role in promoting mass consumption, maintaining continuous and stable economic growth, and overcoming the double middle‐income traps.
Psychometric properties of parent and child reported sleep assessment tools in children with cerebral palsy: a systematic review
Authors: Bautista Manuel , Whittingham Koa , Edwards Priya , Boyd Roslyn N 
Published: November 2017

AimTo determine whether any parent and child report sleep measure tools have been validated in children aged 0–18 years with cerebral palsy (CP).MethodA systematic search of five databases was performed up to June 2017. Studies were included if a sleep measure tool was used to evaluate sleep in children 0–18 years with CP based on international classifications of sleep. Sleep measures were assessed for psychometric data in children with CP.ResultsOnly one paper which used the Schlaffragebogen für Kinder mit Neurologischen und Anderen Komplexen Erkrankungen (SNAKE) questionnaire met the study criteria. The four other measures frequently used in children with CP had no psychometric data available for their use in children with CP. The SNAKE questionnaire has been validated only in children with CP in Gross Motor Function Classification System level V. The Sleep Disturbance Scale for Children and the Pediatric Sleep Questionnaire had the strongest psychometric properties in typically developing children, but has not yet been validated in children with CP.InterpretationCurrent sleep measures being administered in typically developing children are also often used in children with CP, but have not been well validated in this group of children.What this paper adds

There are no condition specific measures of sleep in children with cerebral palsy (CP).

The Schlaffragebogen für Kinder mit Neurologischen und Anderen Komplexen Erkrankungen (SNAKE) questionnaire is validated for children with CP in Gross Motor Function Classification System level V.

A framework to design a CP specific sleep questionnaire is provided.
Violent behaviour in early psychosis patients: Can we identify clinical risk profiles?
Authors: Moulin Valerie , Palix Julie , Golay Philippe , Dumais Alexandre , Gholamrezaee Mohammad Mehdi , Azzola Agathe , Baumann Philipp S. , Alameda Luis , Conus Philippe 
Published: November 2017

AimsThe objective of this study is to explore, within a sample of early psychosis patients (EPP), if subgroups regarding rate of violent behaviour (VB) against others can be identified on the basis of dynamic risk factors (treatment modifiable characteristics).MethodsIn a sample of 265 EPP, treated at the Treatment and Early Intervention in Psychosis Program in Lausanne, we conducted a latent‐class analysis on the basis of the main dynamic VB risk factors (substance use disorder [SUD], positive symptoms, insight, and impulsivity). VB were restricted to “serious violence” and were assessed through patients self‐report, interview with relatives or forensic services and with a standardized instrument.ResultsThe analysis confirmed the heterogeneity of the sample regarding rate of VB. Patients could be stratified within 4 subgroups, 3 of which were at increased risk of VB. The two groups with the highest rates of VB displayed specific clinical profiles. The first one was characterized by high levels of impulsivity, hostility, positive symptoms and SUD, and the second, by low level of insight and low social functioning. These patterns suggest that significant difficulties in social interaction may contribute to the emergence of aggressive reactions against others.ConclusionsIdentification of EPP at increased risk of VB seems possible on the basis of dynamic risk factors. If confirmed prospectively, this could pave the way to the development of preventive strategies and specific interventions.
Detection of adverse drug reactions: evaluation of an automatic data processing applied in oncology performed in the French Diagnosis Related Groups database
Authors: Quillet Alexandre , Colin Olivier , Bourgeois Nicolas , Favrelière Sylvie , Ferru Aurélie , Boinot Laurence , Lafay‐Chebassier Claire , Perault‐Pochat Marie‐Christine 
Published: November 2017

AbstractThe aim of this study was to assess an automated detection method of serious adverse reactions induced by oral targeted therapy (OTT) in patients with cancer, performed in the French Diagnosis Related Groups (DRG) database. Patients with cancer of the Poitiers hospital who started an OTT between 2014 and 2015 were included. This study focused on adverse drug reaction which required inpatient hospitalization (ADRh). All diagnoses coded in the DRG database for hospital stays that occurred within 3 months after OTT initiation were collected (potential ADRh). Filters (exclusion criteria) were automatically applied on potential ADRh to exclude diagnoses that were not adverse drug reactions (false positives). A pharmacovigilance review was carried out to identify ADRh in the medical records (reported ADRh). The sensitivity and specificity of the detection method were estimated for each filter combinations by comparison between potential and reported ADRh. This study included 129 patients. The medical records review led to identify 19 ADRh (all coded in the DRG database) in 14 patients. To maintain a 100% sensitivity of the method detection, the best specificity obtained was 58.3% (95% IC: [55.2–61.4]).The use of restrictive filters (‘drug’ in the diagnostic label, specific diagnosis code for adverse cancer drug reaction) resulted in a 97.8% specificity (95% IC: [96.6–98.5]) with a 38.2% sensitivity (95% IC: [23.9–55.0]). Our method has detected the third of ADRh with an excellent specificity. Complementary experimentations in pharmacovigilance centers are necessary to evaluate the interest of this tool in routine in addition to spontaneous reporting.
Psychological correlates of fear of falling: Findings from the German Aging Survey
Authors: Hajek André , Bock Jens‐Oliver , König Hans‐Helmut 
Published: November 2017

AimThe aim of the present study was to identify general psychological factors related to fear of falling.MethodsData drawn from national probability sampling of the German population aged ≥40 years were used (German Aging Survey; n = 7779). The fear of falling and the psychological factors of loneliness, life satisfaction, positive affect, negative affect, optimism, self‐efficacy, self‐esteem, self‐regulation and perceived stress were collected in self‐administered questionnaires. Multiple logistic regression models controlling for sociodemographic, lifestyle and health‐related variables were used to determine the psychological correlates of fear of falling.ResultsThe prevalence of fear of falling was 18% for all individuals. All psychological factors showed strong bivariate associations with fear of falling. In the multiple regression analyses, higher levels of loneliness, lower life satisfaction, lower positive affect and higher negative affect, as well as lower levels of optimism, self‐efficacy, self‐esteem, self‐regulation and more perceived stress, were associated with increased fear of falling after controlling for sociodemographic factors, various lifestyle factors and morbidity.ConclusionsThe psychological factors considered in the present study are important for characterizing people with fear of falling. Because effective interventions to treat the fear of falling are available, our study might help to address this target group more accurately. Geriatr Gerontol Int 2018; 18: 396–406.
Nutritional profiles of three genotypes of sugarcane silage associated with calcium oxide
Authors: Romão Claudio Oliveira , de Carvalho Gleidson Giordano Pinto , Tosto Manuela Silva Libânio , Santos Stefanie Alvarenga , Pires Aureliano José Vieira , Maranhão Camila Maida Albuquerque , Rufino Luana Marta de Almeida , Correia George Soares , de Oliveira Paulo Andrade 
Published: November 2017

AbstractThe objective of this study was to evaluate, based on chemical composition and in vitro dry matter (DM) digestibility, silages of different sugarcane genotypes after exposure to different doses of calcium oxide (CaO) and to identify that most appropriate dose for use in ruminant feed. The experiment was conducted using a completely randomized 3 × 4 factorial arrangement with three sugarcane genotypes (‘IAC‐862480’, ‘SP‐791011’ and ‘CTC‐3’) and four levels of the additive CaO (0, 15, 30 and 45 g kg−1). A quadratic effect was observed (P < 0.05) for DM content in the silages of genotypes ‘SP‐791011’ and ‘CTC‐3’. The organic matter content of genotypes ‘SP‐791011’ and ‘CTC‐3’ showed a negative linear effect that was associated with the addition of CaO, which promoted an increase in the mineral matter (MM) content in the silages. There was no effect (P > 0.05) of genotype or an interaction effect between genotype and CaO level on crude protein content in the silages. There was an interaction effect (P < 0.05) between genotype and CaO level on the level of neutral detergent fiber in the studied silages and the development of this interaction revealed a linear decrease in neutral detergent fiber in genotype IAC‐86280 and a quadratic effect (P < 0.05) for genotypes ‘SP‐791011’ and ‘CTC‐3’. Potentially degradable DM (pdDM) values showed a positive quadratic function with maxima at 34.8 g kg−1 CaO. The results obtained for potentially degradable neutral detergent fiber (pdNDF) showed that there was a negative linear effect for genotype ‘SP‐791011’ and a quadratic effect with the maximum critical point for genotypes ‘IAC‐862480’ and ‘CTC‐3’. Total DM losses decreased with levels of CaO. All genotypes evaluated showed potential for silage production. The addition of CaO in the ensiling of sugarcane at up to 45 g kg−1 reduces gas and effluent losses and increases the DM recovery of the silages.
Influences of leguminous tree species, Albizia julibrissin Durazz. on growth and feed component characteristics of cool‐season grass, Dactylis glomerata L. beneath the canopy in Japan's temperate zone
Authors: Fukuda Eiki 
Published: November 2017

AbstractTo evaluate the capacity of the deciduous leguminous tree, Albizia julibrissin Durazz. as a fertilizing or shading tree for cool‐season grasses, I investigated its effects on the quantitative and qualitative growth performance of Dactylis glomerata L. from germinated seedlings to adult plants, and on the changes in vegetation under no fertilization conditions in Japan's temperate zone. Height, yield and nutritional contents of D. glomerata beneath and beyond the canopies were compared over 4 years. The plant height and dry matter yield were higher beneath the canopy than beyond the canopy for both the first and the second crops. The nutrient differences between the two locations were larger for the second crop than the first crop. Total digestible nutrients (TDN) and crude protein (CP) were higher beneath the canopy and fibrous components were conversely higher beyond the canopy for the second crop. The TDN yield and CP yield were higher beneath the canopy for both the crops. Weed invasion was suppressed beneath the canopy. These results suggest that the growth of D. glomerata was promoted beneath the canopy of A. julibrissin and that the environment beneath the canopy was more suitable for the cool‐season grass D. glomerata in Japan's hot summers. This is the first demonstration showing the possibility of sustainable grassland production using the deciduous leguminous tree, A. julibrissin and D. glomerata in the cool temperate zone.