bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-center, retrospective evaluation of safety and efficacy of direct oral anticoagulants versus low-molecular-weight heparin and vitamin K antagonist in patients with cancer
Authors: Pritchard Elizabeth R , Murillo Jose R , Putney David , Hobaugh Eleanor C 
Published: August 2017

Introduction The safety and efficacy of direct oral anticoagulants in cancer patients is currently unclear. Low-molecular-weight heparin remains the standard of care for cancer patients with venous thromboembolism, with warfarin, a vitamin K antagonist, as an alternative. Clear recommendations do not exist for patients with both active cancer and non-valvular atrial fibrillation. The objectives of this study were to report safety and efficacy outcomes of direct oral anticoagulants, low-molecular-weight heparin, and vitamin K antagonist in cancer patients with venous thromboembolism or non-valvular atrial fibrillation. Methods Retrospective chart review of adult cancer patients from 2012 to 2015 who received an antineoplastic agent and an anticoagulant. Results A total of 258 patients were reviewed: 80 patients in direct oral anticoagulant group, 95 patients in low-molecular-weight heparin group, and 83 patients in vitamin K antagonist group. Sixty-seven percent of patients were on an anticoagulant for acute or chronic venous thromboembolism. Major bleeding events were similar across the groups (15% direct oral anticoagulant vs 17% low-molecular-weight heparin vs 18% vitamin K antagonist). The most common type of major bleeding event was gastrointestinal bleeding. A total of five fatal bleeding events occurred. Venous thromboembolism recurrence rates were higher in both direct oral anticoagulant (18%) and low-molecular-weight heparin (12%) groups while lower in vitamin K antagonist group (10%) compared to previous studies. Conclusions Cancer patients receiving direct oral anticoagulants, low-molecular-weight heparin, or vitamin K antagonist had similar rates of major bleeding events, with gastrointestinal bleeding being the most common event. Venous thromboembolism recurrence rates were higher in direct oral anticoagulant and low-molecular-weight heparin groups than prior studies. Randomized trials are warranted to establish clear safety and efficacy in this population.
Energy absorption in aluminium honeycomb cores reinforced with carbon fibre reinforced plastic tubes
Authors: Alantali A , Alia RA , Umer R , Cantwell WJ 
Published: August 2017

The energy-absorbing behaviour of an aluminium honeycomb core reinforced with unidirectional and woven carbon fibre reinforced plastic composite tubes has been investigated experimentally at quasi-static rates of strain. Small diameter carbon fibre reinforced plastic tubes, with chamfered ends, were inserted into the cells of an aluminium honeycomb in order to yield a lightweight energy-absorbing material. The resulting data are compared with crushing tests on arrays of free-standing composite tubes, supported on a specially designed compression test fixture. The study continues with an investigation into size effects in the energy-absorbing response of these cellular materials, where compression tests are undertaken on four scaled sizes of reinforced honeycomb core. Crushing tests on the multi-tube arrays have shown that woven carbon fibre reinforced plastic tubes absorb significantly greater levels of energy than their unidirectional counterparts. Here, the specific energy absorption did not vary with the number of tubes in the array, with values for the woven tubes averaging 110 kJ/kg and those for the unidirectional tubes averaging 75 kJ/kg. Inserting composite tubes into aluminium honeycomb served to increase the measured specific energy absorption of the core, resulting in values of specific energy absorption of up to 100 kJ/kg being recorded in the woven-based system. Tests on four scaled sizes of core have shown that the measured SEA does not vary with specimen size, indicating that data generated on small samples can be used to represent the energy-absorbing response of larger, more representative components.
Medical Decision-Making Processes and Online Behaviors Among Cannabis Dispensary Staff
Authors: Peiper Nicholas C , Gourdet Camille , Meinhofer Angélica , Reiman Amanda , Reggente Nicco 
Published: August 2017

Background: Most cannabis patients engage with dispensary staff, like budtenders, for medical advice on cannabis. Yet, little is known about these interactions and how the characteristics of budtenders affect these interactions. This study investigated demographics, workplace characteristics, medical decision-making, and online behaviors among a sample of budtenders. Methods: Between June and September 2016, a cross-sectional Internet survey was administered to budtenders in the San Francisco Bay Area and Greater Los Angeles. A total of 158 budtenders fully responded to the survey. A series of comparisons were conducted to determine differences between trained and untrained budtenders. Results: Among the 158 budtenders, 56% had received formal training to become a budtender. Several demographic differences were found between trained and untrained budtenders. For workplace characteristics, trained budtenders were more likely to report budtender as their primary job (74% vs 53%), practice more than 5 years (34% vs 11%), and receive sales commission (57% vs 16%). Trained budtenders were significantly less likely to perceive medical decision-making as very important (47% vs 68%) and have a patient-centered philosophy (77% vs 89%). Although trained budtenders had significantly lower Internet usage, they were significantly more likely to exchange information with patients through e-mail (58% vs 39%), text message (46% vs 30%), mobile app (33% vs 11%), video call (26% vs 3%), and social media (51% vs 23%). Conclusions: Budtenders who are formally trained exhibit significantly different patterns of interaction with medical cannabis patients. Future studies will use multivariate methods to better determine which factors independently influence interactions and how budtenders operate after the introduction of regulations under the newly passed Proposition 64 that permits recreational cannabis use in California.
Insertion rates and complications of central lines in the UK population: A pilot study
Authors: Wong Adrian VK , Arora Nitin , Olusanya Olusegun , Sharif Ben , Lundin Robert M , Dhadda A , Clarke S , Siviter R , Argent M , Denton Gavin , Dennis Anna , Day Angela , Szakmany Tamas ,   The First Intensive Care National Audit Project (ICNAP-1) group
Published: August 2017

Background Central venous catheters are inserted ubiquitously in critical care and have roles in drug administration, fluid management and renal replacement therapy. They are also associated with numerous complications. The true number of central venous catheters inserted per year and the proportion of them associated with complications are unknown in the UK. Methods We performed a prospective audit at five hospitals, as a feasibility pilot for a larger, nationwide audit. Using a novel secure online data collection platform, developed earlier and adapted for this project, all central venous catheters inserted for patients admitted to the Intensive Care Units were documented at five pilot sites across the UK. Results A total of 117 data collection forms were submitted. Users found the electronic data collection system easy to use. All data fields were ready for analysis immediately after data input. Out of the 117 central venous catheters, 17 were haemodialysis catheters and five pulmonary artery introducers. Experienced practitioners (at least three years’ experience) inserted 85% of the central venous catheters. The site of insertion was the internal jugular vein for 80%, femoral for 12% and subclavian for 8% of central venous catheters. Most central venous catheters were inserted in ICU (49%) or theatres (42%). Ultrasound was used for 109 (93%) of central venous catheter insertions and its use was not associated with fewer complications. In 15 cases venopuncture was attempted more than once (all with ultrasound) and this was associated with significantly increased risk of complications. There were eight immediate complications (6.8%): five related to venopuncture and inability to pass a guidewire, two carotid artery punctures and one associated with significant arrhythmia. Conclusion This study demonstrates the ease and feasibility of collecting detailed descriptive data on central line insertion and its immediate complications in the UK over two weeks. In our proposed nationwide audit, organisation-level data on local policies and standard operating procedures is required to complete the picture on this important aspect of intensive care practice.
Participatory theatre and mental health recovery: a narrative inquiry
Authors: Torrissen Wenche , Stickley Theo 
Published: August 2017

Aims: To identify the potential relationship between participation in theatre and mental health recovery. To give voice to the stories told by participants of Teater Vildenvei, a theatre company that has been part of the rehabilitation programme for mental health service users in Oslo since 1995. Methods: Twelve narrative interviews were conducted among participants of Teater Vildenvei, and the data were subject to a narrative analysis process following the philosophy of Paul Ricoeur and the specific methods of thematic, event and relational analysis as identified by Riessman. Results: The narratives are considered in the theoretical light of the mental health recovery framework as identified by Leamy et al. Each participant had experienced a transformation in identity; the sense of belonging within the group was perceived as highly important to their mental health; engagement with the theatre company gives people something meaningful to do, a sense of hope and individuals feel empowered. Conclusions: This narrative inquiry gave opportunity for participants to elaborate on their stories of their engagement with Teater Vildenvei. It is through the richness of the data that the depth of the significance of meaning that people ascribe to their stories demonstrates the potential power of participatory theatre for mental health recovery. Because of its effects, people make life-changing and life-saving claims.
Neutral tumor evolution in myeloma is associated with poor prognosis
Authors: Johnson David C. , Lenive Oleg , Mitchell Jonathan , Jackson Graham , Owen Roger , Drayson Mark , Cook Gordon , Jones John R. , Pawlyn Charlotte , Davies Faith E. , Walker Brian A. , Wardell Christopher , Gregory Walter M. , Cairns David , Morgan Gareth J. , Houlston Richard S. , Kaiser Martin F. 
Published: August 2017

Key Points
A significant proportion of MM is dominated by neutral evolutionary dynamics. Neutral MM tumors are characterized by shorter survival, consistent with reduced sensitivity to drugs targeting the MM microenvironment.
TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche
Authors: Yahata Takashi , Ibrahim Abd Aziz , Muguruma Yukari , Eren Mesut , Shaffer Alexander M. , Watanabe Nobuo , Kaneko Satoko , Nakabayashi Tetsuo , Dan Takashi , Hirayama Noriaki , Vaughan Douglas E. , Miyata Toshio , Ando Kiyoshi 
Published: August 2017

Key PointsTGF-β–induced intracellular PAI-1 regulates the balance of HSPCs localization between BM and periphery. Intracellular PAI-1 inhibits Furin-dependent maturation of MT1-MMP in HSPCs, resulting in the suppression of HSPC motility.
Hematopoietic stem cell involvement in BCR-ABL1–positive ALL as a potential mechanism of resistance to blinatumomab therapy
Authors: Nagel Inga , Bartels Marius , Duell Johannes , Oberg Hans-Heinrich , Ussat Sandra , Bruckmueller Henrike , Ottmann Oliver , Pfeifer Heike , Trautmann Heiko , Gökbuget Nicola , Caliebe Almuth , Kabelitz Dieter , Kneba Michael , Horst Heinz-August , Hoelzer Dieter , Topp Max S. , Cascorbi Ingolf , Siebert Reiner , Brüggemann Monika 
Published: August 2017

Key Points
BCR-ABL1–positive cells outside the B-lineage compartment are found in 40% of adult patients with BCR-ABL1–positive BCP-ALL. Selection of preexisting CD19– subclones is a potential source of tumor escape after CD19-targeted therapies in adult Philadelphia chromosome–positive ALL.
Impact of Genetic Ancestry on Outcomes in ECOG-ACRIN-5103
Authors: Schneider Bryan P. , Shen Fei , Jiang Guanglong , O’Neill Anne , Radovich Milan , Li Lang , Gardner Laura , Lai Dongbing , Foroud Tatiana , Sparano Joseph A. , Sledge George W. , Miller Kathy D. 
Published: August 2017

Purpose Racial disparity in breast cancer outcomes exists between African American and white women in the United States. We have evaluated the impact of genetically determined ancestry on disparity in efficacy and therapy-induced toxicity for patients with breast cancer in the context of a randomized, phase III adjuvant trial. Methods This study compared outcomes between 386 patients of African ancestry (AA) and 2,473 patients of European ancestry (EA) in a randomized, phase III breast cancer trial, ECOG-ACRIN-5103. The primary efficacy end point, invasive disease–free survival (DFS), and clinically significant toxicities were compared, including anthracycline-induced congestive heart failure, taxane-induced peripheral neuropathy (TIPN), and bevacizumab-induced hypertension. Results Overall, AAs had significantly inferior DFS ( P = .002; hazard ratio, 1.5) compared with EAs. This was significant in the estrogen receptor–positive subgroup ( P = .03), with a similar, nonsignificant trend for those who had triple-negative breast cancer ( P = .12). AAs also had significantly more grades 3 to 4 TIPN (odds ratio [OR], 2.9; P = 2.4 × 10−11) and grades 3 to 4 bevacizumab-induced hypertension (OR, 1.6; P = .02), with a trend for more congestive heart failure (OR, 1.8; P = .08). AAs had significantly more dose reductions in paclitaxel ( P = 6.6 × 10−6). In AAs, dose reductions in paclitaxel had a significant negative impact on DFS ( P = .03), whereas in EAs, dose reductions did not have an impact on outcome ( P = .35). Conclusion AAs had inferior DFS, with more clinically important toxicities, in ECOG-ACRIN-5103. The altered risk-to-benefit ratio for adjuvant breast cancer chemotherapy should lead to additional research with the focus on the impact of genetic ancestry on both efficacy and toxicity. Strategies to minimize dose reductions in paclitaxel, especially as the result of TIPN, are warranted for this population.
Revisiting the phylogeny of phylum Ctenophora: a molecular perspective
Authors: Arteaga-Figueroa Luis A. , Sánchez-Bermúdez Valentina , Franco-Sierra Nicolás D. 
Published: August 2017

The phylogenetic relationships of deep metazoans, specifically in the phylum Ctenophora (inside and outside the phylum), are not totally understood. Several loci (protein coding and ribosomal RNA) from organisms belonging to this phylum are currently available on public databases (e.g. GenBank). Previous studies take into account the ribosomal data and the protein data separately. In this study, we perform a meta-analysis of previously published data together. The published data of this phylum have been used in previous phylogenetic analyses inside the phylum and consist in nuclear ribosomal data, such as 18S, 5.8S, ITS1, ITS2, and protein-coding markers such as NFP (non-fluorescent protein). Previous studies concentrate their efforts toward the analyses of ribosomal data or the protein-coding marker separately. Now we take into account these markers together for an upgrade of the phylogenetic analysis of this phylum. We also test several markers such as 28S, IPNS, Tyrosine aminotransferase and HLH domaincontaining protein for the improvement of the study. This markers were analyzed by Bayesian Inference (MrBayes) and Maximum Likelihood (Garli and RAxML), individually and concatenated, showing improvement in the orders placement and presenting new interesting relationship between the paraphyletic order Cydippida and the other ctenophores. These analyses also include sequences from undescribed species that have been reported in GenBank which improved the alignment matrices and support values of some nodes. Adding the undescribed species suggests interesting and well supported clades, the posterior identification of this species would led to an improvement on the ctenophore’s taxonomy.
Cutaneous vasculitis in children: A nationwide epidemiological study in Spain
Authors: Riancho-Zarrabeitia Leyre , Santurtún Ana 
Published: August 2017

Background: Cutaneous vasculitis (CV) are a complex group of conditions in children, of which IgA vasculitis (IgAV) is the most common. The objectives of the current study are to describe the incidence of CV in Spain and to analyze the temporal trend in the last 11 years, as well as it seasonal distribution. Methods: Hospital discharges of patients aged 0-18 years with a diagnosis consistent with CV in Spain from 2005 to 2015 were collected from the Spanish National Institute of Statistics (INE) databases. Results: A total of 7304 patients from January 2005 to December 2015 were included; 6991 patients (95%) had a diagnosis of IgAV. The yearly incidence in the whole group was 7.7 per 100,000. Mean age at diagnoses was 6±3 years and 52% were male. The highest rate of admissions was found in the 5-9 year-old group, followed by those with 0-4 years of age (15.7 and 9.0 admissions per 100.000, respectively). Admissions due to CV followed an annual cyclic pattern, with the highest number of daily admissions during fall and winter months and the lowest number in summer months. There was an overall downwards trend of the number of hospital admissions during the period of study, in both males and females (p=0.01). Conclusions: We have estimated an incidence of a 7.7 cases per 100,000 CV in children in Spain. CV-related hospitalization rates have a marked seasonal pattern, with a peak in fall and winter and a nadir in summer months. Children between 5 and 9 years of age are most frequently affected. There is a decreasing trend in CV-related hospitalization, the causes of which should be further assessed.
Treatment of a class II malocclusion complicated by digit-sucking
Authors: Shargill Inderjit , Woodhead Peter , Morris David O 
Published: August 2017

This article describes the management of a 12-year-old girl who presented with a Class II division 1 incisor relationship on a Class II skeletal base with an overjet of 10 mm and a thumb-sucking habit. This patient was treated with a modified Herbst appliance to correct the Class II skeletal pattern and break her thumb-sucking habit. CPD/Clinical Relevance: It is important to recognize a digit-sucking habit early as this needs to be eliminated prior to starting orthodontic treatment. This can complicate treatment of patients who require treatment with functional appliances.
Managing the transverse dimension
Authors: Brierley Catherine A , Sandler Jonathan 
Published: August 2017

The management of transverse discrepancies is one of the most challenging aspects of high quality orthodontic treatment. There are many different methods of managing the transverse dimension. We will outline the indications, advantages and disadvantages of these methods. CPD/Clinical Relevance: Transverse discrepancies are a common malocclusion which clinicians need to be able to manage.
The aberrant second premolar
Authors: Mittal Tarun K , Atack Nikki E , Williams Julie C , Puryer James S , Sandy Jonathan R , Ireland Anthony J 
Published: August 2017

Second premolars are one of the last successional teeth to erupt in the maxillary and mandibular arches. Early loss of primary teeth or first permanent molars can lead to disrupted eruption of these teeth. This article gives an overview of the possible aetiology and treatment of the aberrant second premolar. CPD/Clinical Relevance: Awareness of the possible sequelae of unerupted second premolars is important in diagnosis and treatment planning.
Sensitivity of Effluent Variables in Activated Sludge Process
Authors: Vivekanandan B , Jeyannathann K , Rao A. Seshagiri 
Published: August 2017

Abstract
The quality of a treated effluent changes when there is a sudden variation in the influent flow to the wastewater treatment plant during dry, rain, and storm weather conditions. In this study, various influent flow conditions in an activated sludge process are considered that affect the sensitivity of effluent variables such as chemical oxygen demand (COD), biological oxygen demand (BOD), nitrate nitrogen (SNO), ammonical nitrogen (SNH), and total nitrogen (TN) with respect to varying internal recycle flow rate (Qa), sludge recycle flow rate (Qr), sludge wastage flow rate (Qw) and oxygen transfer rate co-efficient of aerobic tanks (KLa(3,4,5)). The analysis has been carried out based on benchmark simulation model no.1 (BSM 1) plant layout which comprises of two models namely activated sludge model no.1 (ASM 1) and simple one dimensional (Simple 1-D) Takacs model. Based on the present analysis, it is observed that the changes in influent flow rate have larger impact on the effluent variables. This variation can be subdued by introducing additional tanks to smoothen the perturbations or using internal recycle rate from the fifth tank in order to maintain the flow around the optimal influent flow rate. The sludge wastage rate has a greater impact on all effluent variables except nitrogenous variables during maximum flow conditions.
On the seductions of psychoanalytic story-telling: Narcissism and the problems of narrative
Authors: Walsh Julie 
Published: August 2017

AbstractIn this paper, I argue for a particular reading of narcissism that challenges the privileging of narrative as a sense-making device, with important consequences for an evaluation of the story paradigm in psychotherapeutic work. I lean on the psychoanalytic mechanisms ofNachträglichkeitand trauma to trouble dominant therapeutic logics that support the primacy of the (narcissistically centered) narrative “I.” Rather than endorse the story of “me, me, me” that popular readings of narcissism invoke, I explore the possibility that, in psychoanalysis, narcissism’s modes destabilize the I, making the narrator constitutionally unreliable, and her accounts of all subject-object distinctions uncertain and constantly shifting.
A generalization of a graph theory Mertens’ theorem: Galois covering case
Authors: Hasegawa Takehiro , Saito Seiken , Sato Iwao 
Published: August 2017

Abstract
In 1874, Franz Mertens proved the so-called Mertens’ theorem, and in 1974, Kenneth S. Williams showed Mertens’ theorem associated with a character.
In a previous paper, we presented a graph-theoretic analogue to Williams’ theorem.
In this paper, we generalize our previous work in the sense that a character is extended to a representation.
To our knowledge, a number-theoretic analogue to our result is not yet known.
So, we expect that, by using our methods, it can be proven in the future.
Petrology and geochemistry of meta-ultramafic rocks in the Paleozoic Granjeno Schist, northeastern Mexico: Remnants of Pangaea ocean floor
Authors: Torres-Sánchez Sonia Alejandra , Augustsson Carita , Jenchen Uwe , Rafael Barboza-Gudiño J. , Alemán Gallardo Eduardo , Ramírez Fernández Juan Alonso , Torres-Sánchez Darío , Abratis Michael 
Published: August 2017

AbstractThe Granjeno Schist is a meta-volcanosedimentary upper Paleozoic complex in northeastern Mexico. We suggest different tectonic settings for metamorphism of its serpentinite and talc-bearing rocks based on petrographic and geochemical compositions. According to the REE ratios (La