bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of oligoprogressive, metastatic castration-resistant prostate cancer (mCRPC) amenable to stereotactic ablative radiotherapy (SABR) in men undergoing abiraterone acetate (AA) therapy.
Authors: McDonald Erica , Cheng Sierra , Arciero Vanessa S. , Saluja Ronak , Zukotynski Katherine A. , Cheung Patrick , Emmenegger Urban 
Published: March 2017

e587 Background: SABR is increasingly used for the treatment of men with oligometastatic prostate cancer, including patients (pts) presenting with oligoprogression. The latter is a clinical situation where a limited number of metastatic tumor sites progress (usually defined as ≤ 3-5), while all other metastases are controlled by a given systemic therapy. The frequency of oligoprogression potentially amenable to SABR is unknown. Methods: Thus, in a retrospective chart analysis we studied the progression pattern of 35 men with chemotherapy-naïve mCRPC undergoing AA therapy, and of 20 men undergoing AA therapy after docetaxel chemotherapy. Applying RECIST1.1 and/or PCWG2 criteria, pts were considered SABR candidates if they radiologically progressed in ≤ 5 distinct metastatic locations, while all other metastases were stable or responding. Results: In chemotherapy-naïve men, pre-AA metastatic lesions were located in bone (94%), lymph nodes (49%), lungs (17%) and liver (3%), whereas progression during AA therapy occurred in bone (89%), lymph nodes (49%), lungs (14%) and liver (9%). 12 pts (34%) fulfilled the criteria of oligoprogression with a median of 2 progressive lesions/pt (range 1-5). 8 pts presented with bone progression only, 3 with nodal progression, and 1 pt with combined bone/nodal progression. Post-docetaxel pts had pre-AA metastatic lesions located in bone (75%), lymph nodes (35%), lungs (5%) and liver (5%). Progression during AA therapy occurred in bone (80%), lymph nodes (75%), lungs (20%) and liver (5%). Only 1 pt met oligoprogression criteria with a single progressive bone metastasis. Conclusions: A sizeable number of men with chemotherapy-naïve mCRPC progressing during AA therapy might be considered for SABR. By contrast, progression of post-docetaxel mCRPC treated with AA is typically widespread. Further efforts are needed to identify criteria for oligoprogressive pts most suitable for SABR with sustained benefit versus men that may progress rapidly with widespread metastases following radiotherapy.
Serial FDG-PET imaging of metastatic prostate cancers reveals intrapatient intermetastases polyclonality through same patient heterogeneous responses to systemic therapy.
Authors: Morin Fannie , Beauregard Jean-Mathieu , Bergeron Michelle , Nguilé-Makao Molière , Lacombe Louis , Fradet Vincent , Fradet Yves , Pouliot Frederic 
Published: March 2017

e590 Background: Although intrapatient prostate cancer (PCa) metastasis polyclonality has been recently characterized by genomic and transcriptomic studies, systemic treatment response heterogeneity has yet to be reported or imaged. It remains unknown if polyclonal differentiation leads to heterogeneous treatment responses between metastases in a single patient undergoing therapy. Methods: Between 2010 and 2015, fifteen patients with metastatic PCa were imaged by FDG-PET/CT before and during systemic therapy, and metabolic response was recorded for individual metastatic lesions. Intermetastasis heterogeneity was defined by opposite metabolic responses of at least two metastases from the same compartment (bone or soft tissue) between the two scans. We examined intrapatient intermetastasis heterogeneity of response to systemic therapy based on the assessment of metabolic response in a total of 165 individual lesions (change in SUVmax, complete response, or new lesion). Change in total lesion glycolysis (TLG) was assessed for each patient. Biochemical response and progression-free survival (PFS) were also recorded. Results: Intrapatient intermetastasis response heterogeneity was found in 40% of cases. In univariate statistical analysis, response heterogeneity was associated with a decrease in PFS (p-value= 0.001), but not with age, CRPC status, Gleason score, PSA-DT, TLG, maximum SUVmax, or sum of SUVmax. In two cases, new metastasis and complete metastasis responses were observed in the same patients. Conclusions: Our results suggest that systemic therapies can induce heterogeneous responses among individual metastases in patients with PCa, supporting the polyclonal evolution of PCa in advanced disease. Molecular imaging may thus be useful to identify clinical resistance earlier after therapy initiation and could also enable targeted biopsy of resistant clones for molecular analysis.
Evaluation of bone metastasis of castration-resistant prostate cancer after enzalutamide and abiraterone using Bone Scan Index on bone scintigraphy.
Authors: Kadomoto Suguru , Izumi Kouji , Nohara Takahiro , Hiroyuki Konaka , Kadono Yoshifumi , Kitagawa Yasuhide , Nakajima Kenichi , Mizokami Atsushi 
Published: March 2017

e596 Background: It was ambiguous till now to evaluate the change of bone metastasis by various treatments. To quantify the change of bone metastases by enzalutamide, abiraterone, and docetaxel for the castration-resistant prostate cancer (CRPC) with bone metastases (bmCRPC), we employed Bone Scan Index (BSI) on bone scintigraphy. Methods: We retrospectively evaluated the change of PSA and bone metastases of CRPC patients who were treated with enzalutamide (Enz), abiraterone (Abi) and/or docetaxel (DOC) in our hospital. All patients underwent Tc-99m MDP bone scintigraphy. The degree of bone metastases was analyzed using BSI, which was calculated by BONENAVI (FUJIFILM RI Pharma, Japan; EXINIbone, EXINI Diagnostics, Sweden). 19 patients were treated with enzalutamide (8 cases: pre-docetaxel, 11 cases: post-docetaxel). The median PSA of patients treated with Enz was 12.64 ng/ml (1.63-199 ng/ml). And 11 patients were treated with abiraterone (5 cases: pre-docetaxel, 6 cases: post-docetaxel). The median PSA of patients treated with Abi was 26.37 ng/ml (2.29-199 ng/ml). Results: We observed decline of PSA in 18/30 cases (9 cases: pre-DOC, 9 cases: post-DOC). Decline of PSA to 50% or more was observed in 14 cases. In contrast, decline of BSI was observed in 53.3% (16/30) cases and decline of PSA to 25% or more was observed in only 6 cases. BSI decreased in 84.6% (11/13) of pre-DOC setting and in 29.4% (5/17) of post-DOC setting indicating that change of BSI was poor in post-DOC setting. However, DOC had already decreased BSI in 91.7% (11/12) before Abi or Enz treatment. Moreover, the average rate of BSI decline in the patients that BSI decreased by DOC was better than the patients that BSI decreased by Abi/Enz (-48.46% vs -28.56%). Finally, although the rate of BSI change by Enz was weakly correlated with the rate of PSA decline (y = 0.3906x + 25.35, R2 = 0.3423), BSI continued to increase in four cases in spite of PSA decline. Conclusions: BSI using BONENAVI on bone scintigraphy was helpful for evaluating the effectiveness of treatment and following-up of bmCRPC.
Does Gleason pattern 5 influence the efficacy of enzalutamide against castration-resistant prostate cancer?
Authors: Shimomura Tatsuya , Yamada Hiroki , Naruoka Takehito , Mori Keiichiro , Hata Kenichi , Igarashi Taro , Kimura Takahiro , Egawa Shin 
Published: March 2017

e598 Background: In this study, we evaluated our cohort treated with enzalutamide retrospectively. We focused on Gleason pattern 5 prostate cancer which was very aggressive cancer and we investigated the difference in efficacy of enzalutamide between the groups including Gleason pattern 5 or not, to understand if initial aggressiveness of prostate cancer influence the enzalutamide responses. Methods: A total of 190 CRPC cases treated with enzalutamide between June 2014 and July 2016 at our university and affiliated institutions were included in this study. We evaluated clinical and pathological factors, Prostate specific antigen(PSA) responses, and overall survival, retrospectively. Results: Of these, 80 cases did not have Gleason pattern 5 and 110 cases had Gleason pattern 5 (Gleason Score 4+5, 5+4 or 5+5). Initial PSA level was higher and metastasis was more frequent in Gleason pattern 5 group (p = 0.0328, and 0.0171, respectively). Docetaxel pretreatment, abiraterone pretreatment, PSA and other serological data at starting enzalutamide were not different between the groups other than steroidal use (p = 0.0441). Overall survival rate at 1 year and 2 years were 84.3% and 77.2% in Gleason pattern 5 negative cohort, and 81.2% and 63.5% in Gleason pattern 5 cohort (p = 0.2459). There were no differences in terms of PSA responses between these groups. Mean PSA decline rate (pattern 5 negative vs. positive) were 57.1% vs. 54.6% (p = 0.6555). ≥ 50% PSA decline rate were 62.5% vs. 60.9% (p = 0.8329), ≥ 90% decline rate were 28.75% vs. 28.2% (p = 0.9317). Conclusions: In this study, we concluded that aggressiveness of initial status did not influence the efficacy of enzalutamide treatment. And disease status might be almost same when introducing enzalutamide. Of course, we need to recognize that initial androgen deprivation therapy (ADT) could be more efficient for lower Gleeson pattern than higher Gleeson pattern. However there is possibility that aggressiveness of prostate cancer cell would change through ADT and/or chemotherapy. We should investigate how prostate cancer is changing and should evaluate the prostate cancer cell status before starting treatment to predict the efficacy and to decide the treatment agents.
Absorption of a novel formulation of abiraterone acetate (AA) fine particle (AAFP) under fed and fasted conditions.
Authors: Papangelou Alexander , Olszanski Anthony J. , Stein Cy Aaron , Zhang Yuxin , Bosch Bill , Nemeth Paul 
Published: March 2017

e606 Background: AA is approved for treatment of metastatic castration-resistant prostate cancer (mCRPC). In healthy subjects administered the originator AA (OAA) formulation, AUC and Cmaxincreased by 10- and 17-fold, respectively, when administered after a high-fat meal relative to the fasted state.1 AAFP is a proprietary formulation (utilizing SoluMatrix Fine-Particle Technology) of AA designed to improve the oral bioavailability (BA) of AA, and to potentially reduce food effects compared with the OAA formulation. In healthy subjects, AAFP 500 mg was established as bioequivalent to OAA 1000 mg in a prior study when taken in fasted conditions. Methods: Healthy male subjects (N = 25) fasted 10-h overnight before randomization in a crossover design to a single 500 mg dose of AAFP under fasted or fed (high-fat FDA breakfast 30 min before AAFP administration) conditions. There was a 7-day washout period prior to crossover; 22 subjects completed the study. Results: Drug exposure of AAFP 500 mg was significantly ( P< 0.0001) greater under fed vs fasted conditions (Table). Following a single dose of AAFP 500 mg, relative BA measured by the ratio of test-to-reference geometric means of AUC and Cmax of abiraterone indicated that drug exposure increased under fed conditions by approximately 4.5- and 6.5-fold, respectively, vs under fasted conditions. AAFP 500 mg was safe and well-tolerated under fed or fasted conditions. Conclusions: AAFP 500 mg under fed conditions has higher BA than under fasted conditions. A direct comparative study between AAFP 500 mg and OAA 1000 mg under restricted food conditions is underway in patients with mCRPC. 1US FDA. CDER. Abiraterone Acetate NDA 202379 Review, 2010. Clinical trial information: NCT02737332. [Table: see text]
Zebra finches have a light-dependent magnetic compass similar to migratory birds
Authors: Pinzon-Rodriguez Atticus , Muheim Rachel 
Published: March 2017

ABSTRACTBirds have a light-dependent magnetic compass that provides information about the spatial alignment of the geomagnetic field. It is proposed to be located in the avian retina and mediated by a light-induced, radical-pair mechanism involving cryptochromes as sensory receptor molecules. To investigate how the behavioural responses of birds under different light spectra match with cryptochromes as the primary magnetoreceptor, we examined the spectral properties of the magnetic compass in zebra finches. We trained birds to relocate a food reward in a spatial orientation task using magnetic compass cues. The birds were well oriented along the trained magnetic compass axis when trained and tested under low-irradiance 521 nm green light. In the presence of a 1.4 MHz radio-frequency electromagnetic (RF)-field, the birds were disoriented, which supports the involvement of radical-pair reactions in the primary magnetoreception process. Birds trained and tested under 638 nm red light showed a weak tendency to orient ∼45 deg clockwise of the trained magnetic direction. Under low-irradiance 460 nm blue light, they tended to orient along the trained magnetic compass axis, but were disoriented under higher irradiance light. Zebra finches trained and tested under high-irradiance 430 nm indigo light were well oriented along the trained magnetic compass axis, but disoriented in the presence of a RF-field. We conclude that magnetic compass responses of zebra finches are similar to those observed in nocturnally migrating birds and agree with cryptochromes as the primary magnetoreceptor, suggesting that light-dependent, radical-pair-mediated magnetoreception is a common property for all birds, including non-migratory species.
Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review
Authors: Alvarez María Fernanda , Bolívar-Mejía Adrián , Rodriguez-Morales Alfonso J. , Ramirez-Vallejo Eduardo 
Published: March 2017

Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. Methods: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease. Cardiac compromise is not so common in isolated episodes; but countries where chikungunya virus is an epidemic should be well informed about this condition. We used 6 bibliographical databases as resources: Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue reports on cardiovascular affectation were included as well, to compare both arbovirus’ organic affectations. Articles that delved mainly into the rheumatic articular and cutaneous complications were not considered, as they were not in line with the purpose of this study. The type of articles included were reviews, meta-analyses, case-controls, cohort studies, case reports and case series. Results: Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at least mentioning CHIKV cardiovascular compromise within the systemic affectation. Cardiovascular manifestations can be considered common and have been reported in France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive insufficiency, heart failure and altered function profile (Troponins, CPK). Conclusions: Physicians should be encouraged to keep divulgating reports on the cardiovascular involvement of chikungunya virus disease, to raise awareness and ultimately encourage suitable diagnosis and intervention worldwide.
Enhancement of glucose oxide electron-transfer mechanism in glucose biosensor via optimum physical chemistry of functionalized carbon nanotubes
Authors: TermehYousefi Amin , Tanaka Hirofumi , Bagheri Samira 
Published: March 2017

AbstractNanostructures are a viable candidate for the construction of simple blood sugar monitoring devices. Electrochemical oxidation based on the immobilization of glucose oxidase (GOx) on carbon nanostructures has paved the way for a modern approach to the determination of glucose levels in blood. Carbon nanotubes (CNTs) exhibit excellent electrical properties, resulting in increased interest in glucose biosensors based on CNTs. Its large surface area and optimum aspect ratio increase the total amount of immobilized biomaterials onto its surface. In this contribution, recent advances in the development of reliable methods to improve the electron-transfer mechanism of GOx in CNT-based glucose biosensors are highlighted. Moreover, mass production and growth mechanism of purified CNTs by chemical vapor deposition were discussed by emphasizing its growth-control aspects.
Multimodale Sehflächen lesen. Eine semiotische Analyse jugendlicher Bekleidung
Authors: Staubach Katharina 
Published: March 2017

AbstractBy the way that we dress, we communicate a certain style to our social environment. Because of a process of searching and expressing an own identity, fashion and self-stylization processes have a special significance to young people in adolescence. The following article investigates the ways in which a youthful style can be expressed by the clothing of young people. Subject of the analysis is the multimodal language-picture-text prints in a corpus of 70 T-shirt- and sweatshirt photographs of adolescents’ clothes. Special focus is placed on the characteristics of linguistic and visual elements as well as on their multimodal relations.
Johannes Brassart’s Summus secretarius
Authors: Saucier Catherine 
Published: March 2017

The motet Summus secretarius remains an enigma in the polyphonic output of the south Netherlandish composer Johannes Brassart (ca. 1400/5–1455). While extant sources (I-Bc Q15 and GB-Ob 213) attest to Brassart’s authorship, the message and function of this motet have long perplexed musicologists seeking to identify the work’s elusive subject and understand its cryptic language. Who is the “highest secretary” hailed at the outset, and what is this figure’s relationship to the biblical and cosmological references in the ensuing lines?
Summus secretarius reveals its secrets when examined within the context of the medieval cult of St. John the Evangelist. Taking cues from Brassart’s careful musical treatment of words quoted from the Gospel of John (1:1), we can decipher the motet’s language and symbolism using a diverse array of exegetical writings, images, and liturgical music that illuminate the unique status of John as Christ’s most intimate confidant, the seer and evangelist privy to his secrets. Brassart would have experienced the evangelist’s cult most vividly through his service as singer, chaplain, priest, and canon at the collegiate church of Saint-Jean l’Evangéliste in Liège—the most likely place for the motet’s composition and performance. Summus secretarius demonstrates to an exceptional degree the hermeneutic richness of enigmatic language in the unique texts of freely composed fifteenth-century motets.
MANAGEMENT OF ENDOCRINE DISEASE: Quality of life tools for the management of pituitary disease
Authors: Webb Susan M , Crespo Iris , Santos Alicia , Resmini Eugenia , Aulinas Anna , Valassi Elena 
Published: March 2017

Background
In the last few years, quality of life (QoL) has become an outcome measure in patients with pituitary diseases.

Objective
To describe the available data on QoL impairment evaluated with questionnaires in patients with pituitary diseases.

Design
Critical review of the pertinent literature and pragmatic discussion of available information.

Methods
Selection of relevant literature from PubMed and WOK, especially from the last 5 years and comprehensive analysis.

Results
QoL is impaired in all pituitary diseases, mostly in acromegaly and Cushing’s disease (similar to other causes of Cushing’s syndrome), but also in non-functioning pituitary adenomas and prolactinomas, especially in the active phase of the disease. Nevertheless, even after endocrine ‘cure’, scores tend to be below normative values, indicative of residual morbidity after hormonal control. The presence of hypopituitarism worsens subjective QoL perception, which can improve after optimal substitution therapy, including recombinant human growth hormone, when indicated.

Conclusions
To improve the long-term outcome of pituitary patients, helping them to attain the best possible health, it appears desirable to include subjective aspects captured when evaluating QoL, so that the affected dimensions are identified and if relevant treated. Additionally, being aware that treatment outcome may not always mean complete normalisation of physical and mental issues related to QoL can be a first step to adaptation and conforming to this new status.
ATTACHMENT PLACE: STUDI FENOMENOLOGI SPECIAL PLACE ANAK USIA DINI DI PAUD ISLAM DAN TK ISLAM DI KABUPATEN MALANG
Authors: Mukhlis Akhmad 
Published: March 2017

<p>Bahasa Indonesia:</p><p>Penelitian ini bertujuan untuk mengetahui kelekatan tempat (<em>attachment place</em>) pada anak usia dini. Berbeda dengan penelitian-penelitian sebelumnya, penelitian ini memfokuskan kajiannya pada tempat-tempat yang dianggap spesial (<em>special place</em>) oleh anak di lingkungan rumah mereka. Metodologi fenomenologi dipilih untuk mengeksplorasi tujuan penelitian dalam dua tahap. Tahap pertama dilkaukan di sekolah dengan mendiskusikan buku dengan 13 peserta didik. Tiga anak yang paling aktif dan mampu berkomunikasi dengan baik diminta untuk menjadi partisipan pada tahap kedua yaitu kunjungan rumah. Dua tahapan penggalian data menemukan bahwa anak-anak memiliki banyak tempat yang dianggap spesial. Keberadaan tempat-tempat tersebut biasa digunakan untuk bersembunyi, meredakan emosi, bermain dan mengembangkan rasa otonomi diri.</p><p> </p><p>English:</p><p>-</p>