bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights From the UK Myocardial Ischemia National Audit Project Registry
Authors: Mamas Mamas A. , Kwok Chun Shing , Kontopantelis Evangelos , Fryer Anthony A. , Buchan Iain , Bachmann Max O. , Zaman M. Justin , Myint Phyo K. 
Published: November 2016

Background

We aim to determine the prevalence of anemia in acute coronary syndrome (
ACS
) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national
ACS
cohort.

Methods and Results

The Myocardial Ischemia National Audit Project (
MINAP
) registry collects data on all adults admitted to hospital trusts in England and Wales with diagnosis of an
ACS
. We conducted a retrospective cohort study by analyzing patients in this registry between January 2006 and December 2010 and followed them up until August 2011. Multiple logistic regressions were used to determine factors associated with anemia and the adjusted odds of 30‐day mortality with 1 g/dL incremental hemoglobin increase and the 30‐day and 1‐year mortality for anemic compared to nonanemic groups. Analyses were adjusted for covariates. Our analysis of 422 855 patients with
ACS
showed that 27.7% of patients presenting with
ACS
are anemic and that these patients are older, have a greater prevalence of renal disease, peripheral vascular disease, diabetes mellitus, and previous acute myocardial infarction, and are less likely to receive evidence‐based therapies shown to improve clinical outcomes. Finally, our analysis suggests that anemia is independently associated with 30‐day (
OR
1.28, 95%
CI
1.22‐1.35) and 1‐year mortality (
OR
1.31, 95%
CI
1.27‐1.35), and we observed a reverse J‐shaped relationship between hemoglobin levels and mortality outcomes.

Conclusions

The prevalence of anemia in a contemporary national
ACS
cohort is clinically significant. Patients with anemia are older and multimorbid and less likely to receive evidence‐based therapies shown to improve clinical outcomes, with the presence of anemia independently associated with mortality outcomes.
Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study
Authors: Gundlund Anna , Olesen Jonas Bjerring , Staerk Laila , Lee Christina , Piccini Jonathan P. , Peterson Eric D. , Køber Lars , Torp‐Pedersen Christian , Gislason Gunnar H. , Fosbøl Emil Loldrup 
Published: November 2016

Background

We examined all‐cause mortality and long‐term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (
AF
).

Methods and Results

Using Danish nationwide registry data, we identified all patients diagnosed with
AF
(1995–2012) and divided them into those with familial
AF
(having a first‐degree family member with a prior
AF
admission) and those with nonfamilial
AF
. We paired those with and without familial
AF
according to age, year of
AF
diagnosis, and sex in a 1:1 match. Using cumulative incidence and multivariable Cox models, we examined the risk of long‐term outcomes. We identified 8658
AF
patients (4329 matched pairs) with and without familial
AF
. The median age was 50 years (interquartile range 43–54 years), and 21.4% were women. Compared with nonfamilial
AF
patients, those with familial
AF
had slightly less comorbid illness but similar overall
CHA
2
DS
2
‐
VAS
c score (
P
=0.155). Median follow‐up was 3.4 years (interquartile range 1.5–6.5 years). Patients with familial
AF
had risk of death and thromboembolism similar to those with nonfamilial
AF
(adjusted hazard ratio 0.91 [95% CI 0.79–1.04] for death and 0.90 [95%
CI
0.71–1.14] for thromboembolism).

Conclusions

Although family history of
AF
is associated with increased likelihood for development of
AF
, once
AF
developed, long‐term risks of death and thromboembolic complications were similar in familial and nonfamilial
AF
patients.
Hearing Preservation After Penetrating Cochlear Injury
Authors: Tarasidis George S. , Wiggins Richard H. , Gurgel Richard K. 
Published: November 2016

Objectives: To share results and recommendations for management of penetrating cochlear injury. Methods: A patient underwent repair of a penetrating cochlear injury after a projectile led to a traumatic cochleostomy with a narrow miss of the facial nerve and intracranial carotid artery. Results: Postoperatively, the patient’s audiogram demonstrated a pure tone average of 47.5 dB for air conduction and 35 dB for bone conduction, worse in the high frequencies, with a Word Recognition Score of 76%. Conclusions: Hearing loss from a penetrating cochlear injury can be mitigated with early repair, minimizing inner ear trauma, and steroid use to treat posttraumatic labyrinthitis.
CD11d β2 integrin expression on human NK, B, and γδ T cells
Authors: Siegers Gabrielle M , Barreira Christy R , Postovit Lynne-Marie , Dekaban Gregory A 
Published: November 2016

Abstract
The CD11d integrin is expressed on the cell surface of leukocytes that belong to the myeloid lineage, but its expression on lymphocytes remains unexplored. To test the hypothesis that CD11d is expressed on lymphocyte subsets, we employed a multicolor flow cytometry panel to identify CD11d expression on B, NK, CD4+ and CD8+ αβ T cells (αβTc), and γδ T cells (γδTc) in human PBMC samples. CD11d was highly expressed on NK cells, B cells, and γδTc, but not αβTc. CD11d expression was higher on freshly isolated γδTc compared with αβTc from healthy donors, yet both inter- and intradonor variability was evident. Over time in primary culture, we consistently observed higher CD11d levels on γδTc compared with αβTc from the same donor. Furthermore, CD11d expression on γδTc increased over time and correlated with levels of IL-2 supplementation. Of interest, a greater percentage of Vδ1 γδTc expressed CD11d than did Vδ2 γδTc, which suggested differential roles for this integrin that may segregate with γδTc subsets. These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease.
A Mesoporous ZSM-5 Zeolite Synthetized by a Novel Double Long-Alkyl-Chain Organosilane Template
Authors: Zhao Jun , Liu Dongliang 
Published: November 2016

Abstract
A ZSM-5 zeolite molecular sieve was prepared by using a new type of double long-alkyl-chain organosilane template. The structure of the acquired zeolite was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and nitrogen adsorption–desorption measurement, which showed a piled circular sponge crystal morphology and contained mesopores around 4 nm in it.
Is atomoxetine effective in some comorbid mental disorders in ADHD?
Authors: Cesneková D. , Šnircová E. , Nosáľová G. , Ondrejka I. 
Published: November 2016

Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is connected with high level of psychiatric comorbidity in paediatric population. Depressive disorder is common comorbid disorder co-existing with ADHD. Atomoxetine is worldwide approved for treatment of ADHD in paediatric population; in addition atomoxetine is effective and safe in treatment of some comorbid disorders in ADHD. Pharmacotherapy of depression is limited and residual symptoms are common. Fluoxetine is currently considered to be the gold standard of treatment of depression, but effectiveness of acute phase of treatment is not sufficient. Atomoxetine as a selective noradrenaline reuptake inhibitor or olanzapine as a multi receptors antagonist drug in combination with fluoxetine could be perspective augmented treatment strategy of depression just for their antidepressant effect. The aim of our following study is to evaluate and compare effectiveness and safety of monotherapy and combined/augmented therapy in acute phase of depression treatment in adolescence, as well as introduce complex modern research methodology of effectiveness and safety of treatment.
Gemeinsamer Alltag – geteilter Lebensraum? Der Frankfurter Wochenmarkt als christlich-jüdischer Begegnungsort
Authors: Kasper-Marienberg Verena 
Published: November 2016

AbstractWeekly markets and cattle markets, as well as local and international fairs, were important places of encounter for Jews and Christians in the early modern period. Weekly grocery markets in particular have drawn only little attention in terms of being »Jewish spaces«, but Jewish men and women were an integral part of them just like Christian men and women were. As both customers and vendors, Jews shaped the customs, times, supply and kinds of offered groceries at these markets. The weekly grocery market of Frankfurt am Main can serve as an example for examining the social interactions as well as the spatial dynamics that could develop in such a closely regulated, hierarchically structured and religiously shaped market space.
Genetic studies revealed differences between European and North American populations of Calypogeia azurea
Authors: Buczkowska Katarzyna , Bączkiewicz Alina , Gonera Patrycja 
Published: November 2016

Abstract
Calypogeia azurea, a widespread, subboreal-montane liverwort species, is one of a few representatives of the Calypogeia genus that are characterized by the occurrence of blue oil bodies. The aim of the study was to investigate the genetic variation and population structure of C. azurea originating from different parts of its distribution range (Europe and North America). Plants of C. azurea were compared with C. peruviana, another Calypogeia species with blue oil bodies. In general, 339 gametophytes from 15 populations of C. azurea were examined. Total gene diversity (HT) estimated on the basis of nine isozyme loci of C. azurea at the species level was 0.201. The mean Nei’s genetic distance between European populations was equal to 0.083, whereas the mean genetic distance between populations originating from Europe and North America was 0.413. The analysis of molecular variance (AMOVA) showed that 69% of C. azurea genetic variation was distributed among regions (Europe and North America), 15% - among populations within regions, and 16% - within populations. Our study revealed that C. azurea showed genetic diversity within its geographic distribution. All examined samples classified as C. azurea differed in respect of isozyme patterns from C. peruviana.
Populations of Orchis militaris, Epipactis palustris and Malaxis monophyllos in the Republic of Mordovia (Central Russia)
Authors: Khapugin Anatoliy A. , Silaeva Tatyana B. , Semchuk Anastasia A. , Kunaeva Elena N. 
Published: November 2016

Abstract
Population-based studies of endangered plant species are key methods for assessment of the status for these plants at any territory. Plant species of the Orchidaceae family are sensitive components in natural ecosystems. That is why determination of the status for their populations can be considered as indicators for the status of natural ecosystem position as a whole. Investigations of three Orchidaceae species populations (Orchis militaris L., Epipactis palustris (L.) Crantz, Malaxis monophyllos (L.) Swartz) were carried out in Central Russia (Republic of Mordovia). Abundance, density, structure and dynamics of populations of these species were studied. Species composition of accompanying flora was established for each rare species. Some morphometrical parameters of individuals for the studied species were measured. Features of ontogenetic spectrum for Orchis militaris and Epipactis palustris populations were shown.
Changes in the phytoplankton diversity of two oxbow lakes in a big city: a case study of Wrocław (Poland)
Authors: Richter Dorota , Bączek Paulina 
Published: November 2016

AbstractThe subject of this study is to analyse changes in the taxonomic structure and development intensity of phytoplankton and, thus, to determine the diversity of cyanobacteria and algae along with the trophy state of two oxbow lakes in the Wrocław area (south-western Poland). The analysis of samples and data from previous years showed a total of 244 cyanobacteria and algae species within these two lakes. The species composition changed significantly in both of them – there were found 90 species new to the studied flora (37% of current flora) and 74 species which were previously recorded. The diversity of cyanobacteria and algae reflects the conditions in these water bodies and each change in ecological conditions (e.g., anthropological dangers) is reflected by a change in the phytoplankton assemblage structure. Consequently, knowledge of taxonomic diversity is useful in monitoring water bodies to preserve them in good conditions. Both studied oxbow lakes belong to eutrophic ecosystems as evidenced by their phycoflora, which is rich in species characteristic of high-trophy water, and recorded water blooms. The analysis of changes in cyanobacterial and algal assemblages in these lakes was also a basis for determining their trophy and finding it to be progressively eutrophic. Regular phycological studies of Wrocław numerous water bodies are essential and, in the future, will allow us to protect them and to react quickly in case of danger to these ecosystems. It will also allow us to study eutrophication processes in the water bodies that are crucial to the city.
A National Dividend vs. a Basic Income – Similarities and Differences
Authors: Heydorn M. Oliver 
Published: November 2016

AbstractThe following article will briefly compare and contrast the Social Credit proposal of a National Dividend, which was one of the three key planks in C.H. Douglas’ monetary reform proposals, with the contemporary call for the introduction of a basic income. In some ways, the National Dividend and the basic income (as typically conceived) are quite similar. One of the basic purposes of each is to eliminate or at least reduce poverty by providing each citizen with a secure income that is independent of employment. However, when it comes to the structural nature of the proposed benefit, its relationship to the existing social structure, and, finally, the methods that have been proposed for financing it, there are significant differences between the National Dividend and a conventional basic income that must not be overlooked.
Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target
Authors: Brynychova Veronika , Hlavac Viktor , Ehrlichova Marie , Vaclavikova Radka , Nemcova-Furstova Vlasta , Pecha Vaclav , Trnkova Marketa , Mrhalova Marcela , Kodet Roman , Vrana David , Gatek Jiri , Bendova Marie , Vernerova Zdenka , Kovar Jan , Soucek Pavel 
Published: November 2016

Abstract

Background:
Apoptosis plays a critical role in cancer cell survival and tumor development. We provide a hypothesis-generating screen for further research by exploring the expression profile and genetic variability of caspases (2, 3, 7, 8, 9, and 10) in breast carcinoma patients. This study addressed isoform-specific caspase transcript expression and genetic variability in regulatory sequences of caspases 2 and 9.

Methods:
Gene expression profiling was performed by quantitative real-time PCR in tumor and paired non-malignant tissues of two independent groups of patients. Genetic variability was determined by high resolution melting, allelic discrimination, and sequencing analysis in tumor and peripheral blood lymphocyte DNA of the patients.

Results:
CASP3 A+B and S isoforms were over-expressed in tumors of both patient groups. The CASP9 transcript was down-regulated in tumors of both groups of patients and significantly associated with expression of hormonal receptors and with the presence of rs4645978-rs2020903-rs4646034 haplotype in the CASP9 gene. Patients with a low intratumoral CASP9A/B isoform expression ratio (predicted to shift equilibrium towards anti-apoptotic isoform) subsequently treated with adjuvant chemotherapy had a significantly shorter disease-free survival than those with the high ratio (p=0.04). Inheritance of CC genotype of rs2020903 in CASP9 was associated with progesterone receptor expression in tumors (p=0.003).

Conclusions:
Genetic variability in CASP9 and expression of its splicing variants present targets for further study.
A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum
Authors: Basu Sankha S. , Petrides Athena , Mason Donald S. , Jarolim Petr 
Published: November 2016

AbstractBackground:Triazole antifungals are essential to the treatment and prophylaxis of fungal infections. Significant pharmacokinetic variability combined with a clinical need for faster turnaround times has increased demand for in-house therapeutic drug monitoring of these drugs, which is best performed using mass spectrometry-based platforms. However, technical and logistical obstacles to implementing these platforms in hospital laboratories have limited their widespread utilization. Here, we present the development and validation of a fast and simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to measure fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole in human serum suitable for incorporation into a hospital clinical laboratory.Methods:Serum samples (20 µL) were prepared using protein precipitation in the presence of deuterated internal standards. Chromatographic separation was accomplished using reversed phase UPLC and analysis was performed using positive-mode electrospray ionization and collision-induced dissociation MS.Results:Total analytical run time was 3 min. All analytes demonstrated linearity (r2>0.998) from 0.1 to 10 µg/mL (1–100 µg/mL for fluconazole), acceptable accuracy and precision (%DEV<15% and %CV<15% at all levels tested), suitable stability under relevant storage conditions, and correlated well with reference laboratory results.Conclusions:A simple and rapid UPLC-MS/MS method for monitoring multiple triazole antifungals was developed with a focus on the needs of hospital laboratories. The assay is suitable for clinical utilization and management of patients on these medications.
Study of the Anti – Pregnancy - Associated Glycoprotein (Anti – Pag) Resulted from Antigen Pag Immunization, as Prospective Early Pregnancy Detector in Animals
Authors: Lestari Tita Damayanti 
Published: November 2016

Abstract
Blastocyst protein named pregnancy-associated glycoprotein (PAG) has been isolated from pregnant dairy cow serum. PAG yielded from previous research issued from pregnant animals, wherein was specifically produced. This study is an initial research to use PAG as an antigen to be injected to rabbit in order to produce the corresponding antibody. The objective of the research was to study the character of anti-pregnancy-associated glycoprotein (Anti-PAG), as a result of immunization of PAG and to learn its specification reaction. The PAG isolate had bovine origin (molecular weight-MW of 67.34 kDa) and issued from previous research. Injection of PAG isolate could stimulate the production of Anti-PAG as an immunization response. Immunization was done by double booster inoculation. Anti-PAG derived from immunization was characterized via antibody titer value using ELISA technique. Specificity test of Anti-PAG was carried on by Western Blot technique. Results revealed that injection of PAG isolate to the rabbit stimulates anti-PAG production. Concentration of Anti-PAG was 1.192 μg with titer of 1.044. Anti-PAG derived from rabbits recognized Standard PAG antigen (bovine PAG MDBiomed cat. 101-7963-13-3) and PAG isolate derived from previous research. The reaction of antigen antibody is the basic structure of creating a gestation detection kit. Anti-PAG is expected to be the molecular marker in developing a gestation detection kit in the near future.
Mimesis
Authors: Raulet Gérard 
Published: November 2016

Abstract
This text is a discussion of Walter Benjamin’s speculation on a so called “mimetic faculty” as well as a critical position to the debate between Philosophical Anthropology and Critical Theory which can be considered as insufficient until now. Although Axel Honneth regards it as rather marginal, Benjamin’s approach is much more radical than his own paradigm of recognition – and this not only in anthropological respect but also with regard to the core of the problem: the reification and the domination of the form of commodity.
Körper, Geist, Empfindung
Authors: Mulsow Martin 
Published: November 2016

AbstractAs a member of the Illuminati Order, Karl Leonhard Reinhold wrote an – hitherto unknown – expert report about an internal manuscript on “The development of the forces of our mind” in January 1785. The manuscript had outlined a materialist theory of sensations and a conception of the interplay of the drives of pleasure and self-preservation. Reinhold, being in his early Kantian phase, criticized the materialism of this theory. In his own development, however, Reinhold returned soon to the topic of the drive of pleasure (in hisÜber die Natur des Vergnügens, 1788/89), where he does not totally exclude the materialism of Helvetius, but includes his conception in a synthetic Kantian approach.
Logische und andere Räume
Authors: Keiling Tobias 
Published: November 2016

AbstractSpatial metaphors have peculiar prominence in accounts of rationality, such as in the phrase “space of reason” made prominent by Wilfrid Sellars and John McDowell. This article attempts to understand the potential of such comparisons of reason to space, taking Wittgenstein’s metaphor of “logical space” as exemplary. As Hans Blumenberg observes in his reading of Wittgenstein and in contrast to its stated aim, the account of “logical space” in theTractatusdoes not achieve a final delimitation of reason. Wittgenstein’s discussion of different forms of rationality rather leads him to consider a plurality of spaces. Asking how these different spaces or fields of meaning can be congruent at all, Wittgenstein is led to consider the indeterminacy of space itself in contrast to the different localizations it allows.
Die Vorteile des Pragmatismus in Theorien Kosmopolitischer Gerechtigkeit
Authors: Bray Daniel 
Published: November 2016

Abstract
This article explores the Pragmatist and Rawlsian forms of cosmopolitanism that have emerged in recent decades in efforts to extend theories of justice to the global level. The Pragmatist approach is critical and problem-centred, using an account of the problematic situation and a reconstruction of inherited ideals to develop normative theories for action in a specific political context. The Rawlsian approach is abstract and systemic, deducing ideal institutional principles from thought experiments that require later implementation in the non-ideal world. The main argument of the article is that Pragmatists employ three methodological elements that give them important practical advantages over Rawlsians in providing action-guiding norms. First, a detailed account of the problem of injustice provides an indispensable empirical grounding that frames normative responses. Second, a critical reconstruction of the normative vocabulary relating to the problem ensures that the ideals used to guide action are historically relevant to the community of action. And finally, an account of normative theories in terms of their concrete requirements and means of realisation in the particular situation ensures they are attuned to its political constraints and possibilities for change.