bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double Perspective
Authors: Ginsberg Gina , Weiner Ann 
Published: September 2016

We thought our son was advanced even as a baby, but as we had no other children we weren't sure. He began to cross-country ski with us when he was two, and learned to ice skate from a children's instructor at four. Now, at seven, he's on a pee-wee hockey team and won an award this past season. We didn't know much about school programs and enrolled him without question in first grade. The following spring (he turned 6 in April) we took him for an independent evaluation at a university connected child study center. We were rather astounded by the findings. On the Binet test our son was found to have an IQ of 150. On an achievement-type test his placement looked like this: Math—grade 5.3, Word Recognition—grade 6.4, Reading Comprehension—grade 4.1, and Spelling—grade 4.2. On a silent reading test, he got a grade level score of 5.8. We arranged a conference with his school principal and teacher and took the report. We felt our son ought to be given more to do as he'd been getting very restless. His teacher wouldn't even read the report as she said she didn't want to be swayed by information other than her own. The principal read it and said that tests didn't tell everything. They both said our son was becoming a behavior problem in the classroom and he shouldn't be given any advanced work until he could learn to control himself. They put him in second grade. Now at age 7, he's not interested in school, doesn't want to do anything hard. His teacher says he is worse than ever and he should be kept back in second grade until he learns to control himself. He has become disobedient and refuses to work at his assignments. We feel desperate. What can we do?
Learning Outcomes in a Simulation Game for Associate Degree Nursing Students
Authors: Clark Carolyn Chambers 
Published: September 2016

Learning outcomes of a simulation game designed to have one-to-one correspondence between behavioral objectives and game plays is reported The behavioral objectives were core concepts in psychiatric mental health nursing taught to associate degree nursing students. Decisions to use the simulation game method grew out of difficulties inherent in the community college nursing program, as well as the need for self-paced, efficient, learner-centered learning and evaluative tools. After the trial and revision of the game, a number of research hypotheses were tested Simulation gaming was found to be an effective mode of learning, and students who acted as teachers for other students learned significantly more than those who were taught. Some of the recommendations for further research were to study varied nursing populations, to add a control group, to test the long-range learning effects of playing the game, to decrease experimenter bias, to study transfer of learning to actual nurse-patient situations and changes in attitudes toward psychiatric patients, and to develop more simulation games for nursing education.
A Treatment Algorithm for Correcting Extensor Lag in Vascularized Toe Proximal Interphalangeal Joint to Finger Transfers
Authors: Lin Yu-Te , Loh Charles , Wei Fu-Chan 
Published: September 2016

Introduction: To improve the arc of motion (AOM) and reduce the extension lag of vascularized toe proximal interphalangeal joint (PIPJ) transfers, simultaneous reconstruction of the extensor mechanism as part of the transfer has been mentioned in our preliminary report. According to diverse tendon conditions of the recipient fingers and donor toes, we rationalize 3 procedures used to reconstruct the extensor mechanism in vascularized joint transfers (VJTs). These include (1) centralization of lateral tendons when intrinsic hand muscles are non-functional, (2) central slip reconstruction when type I toes* are encountered, and (3) direct extensor digitorum longus (EDL)-to-extensor digitorum communis (EDC) repair for type II toes*. In this study, we evaluate the outcomes of VJTs reconstructed using these techniques and propose an updated treatment algorithm based on our findings. Materials and Methods: VJT was performed in a consecutive series of 26 digits in 25 patients (20 males and 5 females). The average age was 30.5 years. There were 14 right hands (dominant) and 12 left hands. Reconstructed digits included 8 index, 10 middle, and 8 ring fingers. Techniques of simultaneous extensor reconstruction included 8 centralization of lateral bands, 5 direct EDL-to-EDC repairs, and 13 central slip reconstructions. Similar protocol of postoperative rehabilitation was applied to all the patients. Results: The patients were followed up for an average of 16.7 months. The overall AOM and extension lag of the reconstructed PIPJ were 57.7° and 17.9° (81.7% functional usage of pretransferred toe PIPJ AOM), respectively. No significant difference in the results was found between the handedness ( P = .23) and between different recipient fingers ( P = .37). Comparing the outcomes of different extensor reconstructions, the extension lag after centralization, direct EDL-to-EDC repair, and central slip reconstruction were 19.4°, 13°, and 18.8° ( P = .42), respectively; The PIPJ AOM was 54.4°, 55°, and 60.8° ( P = .42); the final finger PIPJ AOM compared to the pretransferred toe PIPJ AOM was 76.3%, 79.7%, and 85.9% ( P = .34). Discussion: Due to the varied recipient finger conditions, no single technique is suitable for every scenario. Careful evaluation of recipient finger and toe tendons is required to perform the most appropriate extensor reconstruction. Using our treatment algorithm, consistent outcomes can be produced with reduced extensor lag and maximum usage of potential toe PIPJ AOM. As such, customized extensor mechanism reconstruction is important to improve the outcomes of vascularized toe PIPJ transfers. *In our clinical observations, the majority (>86%) of second toes do not have a strong, definite insertion of central slip at the base of middle phalanx (type I). On the contrary, less than 14% of second toes do have.
High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia
Authors: Chiang Mark Y. , Wang Qing , Gormley Anna C. , Stein Sarah J. , Xu Lanwei , Shestova Olga , Aster Jon C. , Pear Warren S. 
Published: September 2016

Key Points
Notch1 mutations are selected in the murine T-ALL model despite genetic pan-Notch inhibition; other pathways do not easily substitute it. Myc is the key Notch target responsible for Notch-selective pressure in T-ALL as it can substitute for Notch; by contrast, Akt cannot.
The impact of a dedicated physiotherapist clinic for children with dysfunctional breathing
Authors: Barker Nicola J. , Elphick Heather , Everard Mark L. 
Published: September 2016

Dysfunctional breathing is a significant cause of morbidity, adversely affecting an individual's quality of life. There is currently no data from paediatric centres on the impact of breathing retraining for dysfunctional breathing.Symptoms and quality of life were measured in 34 subjects referred sequentially for breathing retraining to the first dedicated paediatric dysfunctional breathing clinic in the UK. Data were obtained prior to the first intervention (time point 1), at discharge (time point 2) and by post 6 months later (time point 3).The mean (interquartile range) age of participants was 13.3 (9.1–16.3) years, with 52% female. Data were obtained at time points 2 and 3 in 23 and 13 subjects, respectively.Statistically significant improvements were observed in symptom scores, child quality of life and parental proxy quality of life between time points 1 and 2 (p<0.0001), while there was no significant difference in the data at time point 3 as compared with time point 2.This study suggests that physiotherapist-led breathing retraining offers significant benefit to young people with dysfunctional breathing which is maintained for at least 6 months after treatment is completed. Future studies will provide more information on the long-term effects of interventions for dysfunctional breathing.
A program evaluation of Kids2Hear, a student-run hearing screening program for school children
Authors: Hu Tina , Stead Katherine , Fu Terence , Papsin Blake 
Published: September 2016

Background Hearing deficits in children are demonstrably negatively associated with language acquisition and cognition. Although universal neonatal hearing screening exists, it is not offered equally across Canada. Additionally, children emigrating from other countries are often not assessed. The objective of this study is to evaluate Kids2Hear, a free hearing screening program run by medical students at elementary schools, and to determine the rate of hearing deficits that were identified and referred for evaluation. Methods Retrospective analysis of screening program data from 228 participants seen at three inner-city elementary schools over six months. Results In our sample, the mean age was 5.8 ± 1.0 years with 48 % males. Approximately 21 participants (9.3 %) were screened positive for a hearing deficit and required referral for supplementary audiological evaluation. About 44 participants (19.3 %) were referred to a family physician for otoscopic abnormalities. Females were significantly more likely to be identified for both hearing deficits and otoscopic abnormalities. Conclusions Hearing deficits and otoscopic abnormalities are common among young children. Female children may be at higher risk for developing hearing issues or otoscopic abnormalities compared to males. Additional research is needed to determine the effectiveness of hearing screening programs.
Structural damage reduction in protected gold clusters by electron diffraction methods
Authors: Ortega Eduardo , Ponce Arturo , Santiago Ulises , Alducin Diego , Benitez-Lara Alfredo , Plascencia-Villa Germán , José-Yacamán Miguel 
Published: September 2016

AbstractThe present work explores electron diffraction methods for studying the structure of metallic clusters stabilized with thiol groups, which are susceptible to structural damage caused by electron beam irradiation. There is a compromise between the electron dose used and the size of the clusters since they have small interaction volume with electrons and as a consequence weak reflections in the diffraction patterns. The common approach of recording individual clusters using nanobeam diffraction has the problem of an increased current density. Dosage can be reduced with the use of a smaller condenser aperture and a higher condenser lens excitation, but even with those set ups collection times tend to be high. For that reason, the methods reported herein collects in a faster way diffraction patterns through the scanning across the clusters under nanobeam diffraction mode. In this way, we are able to collect a map of diffraction patterns, in areas with dispersed clusters, with short exposure times (milliseconds) using a high sensitive CMOS camera. When these maps are compared with their theoretical counterparts, oscillations of the clusters can be observed. The stability of the patterns acquired demonstrates that our methods provide a systematic and precise way to unveil the structure of atomic clusters without extensive detrimental damage of their crystallinity.
A multicomponent 3D seismic tool for shallow gas geohazard detection onshore Gulf Coast
Authors: Chen Percy 
Published: September 2016

Current study demonstrates that multicomponent 3D survey is an efficient tool not only to detect gas but also to delineate its migration pathways in shallow sediments. We have determined that thermogenic gas detected in the study area is represented by amplitude and velocity anomalies, including bright spots, gas clouds, gas sags, and phase changes. Evidence of these anomalies attributed to gas presence is provided by well correlation and amplitude variation with offset crossplot analysis and is further supported by the imaging disparity between P- and converted-S-wave data. Current mapping results suggested a predominant vertical gas migration through faults from the unreported petrochemical products in some sulfur caverns. This conclusion is contrary to earlier studies, which suggest a primarily lateral migration from a gas storage cavern 1219 m (4000 ft) to the west.
Reversible Structural Changes of Strong Hydrogen Bond-Supported Organic Networks Using Neutral 3,5-Pyridinedicarboxylic Acid N-oxide through Solvent Release/Uptake
Authors: Noro Shin-ichiro , Ochi Rika , Kubo Kazuya , Nakamura Takayoshi 
Published: September 2016

Abstract
Crystallization of neutral 3,5-pyridinedicarboxylic acid N-oxide (H2-3,5-pydcao) molecules in the presence/absence of solvent molecules affords neutral hydrogen bond-supported one-dimensional, two-dimensional, and three-dimensional molecular networks of H2-3,5-pydcao·DMF (1·DMF), H2-3,5-pydcao·H2O (1·H2O), and H2-3,5-pydcao (1), respectively, that have strong intermolecular hydrogen bonds of Nδ+–Oδ−⋯HOOC. These molecular networks were found to show reversible structural changes among 1, 1·H2O, and 1·DMF driven by solvent release/uptake.
­­­­­­Recent advances in managing Peyronie’s disease
Authors: Kayes Oliver , Khadr Rauf 
Published: September 2016

Peyronie’s disease remains an under-reported and debilitating problem which can result in significant physical and psychological symptoms for some men. The classic symptom complex includes penile curvature, penile plaque, and penile pain. Men can also present with erectile dysfunction, penile instability, and penile shortening, alongside feelings of low mood/libido, dysmorphobia, and low self-esteem. This review highlights the current key publications in the medical literature and provides updates on new clinical therapies whilst postulating about potential future treatments on the horizon.
Variation in Natural Durability of Seven Eucalyptus grandis × Eucalyptus urophylla Hybrid Clones
Authors: França F. J. N. , França T. S. F. A. , Arango R. A. , Woodward B. M. , Vidaurre G. B. 
Published: September 2016

Abstract
Programs aimed at developing clones of hybrid trees are commonly established in Brazil to meet the demands of various forest-based industries. These programs have continually improved the quality of eucalyptus wood, which has the potential to reduce deforestation by lowering demand for other high-value species. This is particularly true in the lumber market, but little is known about the resistance of eucalyptus wood to biodegradation. This study evaluated variation in natural resistance of seven Eucalyptus grandis × Eucalyptus urophylla hybrid clones to decay by four wood-rot fungi and feeding by subterranean termites. In addition to mass loss, the relationship between density and durability was also examined. Results showed significant differences among the various clones in density as well as in resistance to fungi and termites, although none of the clones were resistant to Trametes versicolor. Mass loss in wood specimens ranged from 9 to 61 percent in the fungal tests and from 6.9 to 20.5 percent in termite tests. Average density measurements among clone groups were calculated to be between 461 and 659 kg/m3. Among the clones, five of the seven showed resistance to fungal decay and termite feeding, which was correlated with increased wood density. Based on these results, we suggest that certain clones, particularly those with higher density values, may be considered for production of various lumber products.
Specific Symptoms of Thyrotoxicosis in Japanese Patients: A Reevaluation of Classical Symptoms in Modern Thyroid Function Tests
Authors: Tagami Tetsuya , Tsuiki Mika , Nakao Kanako , Nakatani Rieko , Kakita Maiko , Ueda Yohei , Matsuo Naomi , Usui Takeshi , Naruse Mitsuhide , Shimatsu Akira 
Published: September 2016

Background: Medical interview of patients can yield clues for the detection of thyroid dysfunction. However, symptoms of thyrotoxicosis as described in textbooks are based on Western populations.Aim: To elucidate specific symptoms of thyrotoxicosis in Japanese patients.Methods: For one year, consecutive patients who visited us for their first medical examination were asked to complete an original questionnaire about their overall complaints.Results: Excluding patients who were already being treated for thyroid dysfunction, 267 subjects were analyzed: 67 overt hyperthyroid patients (T), 11 with subclinical hyperthyroidism (ST), 30 hypothyroid patients (H), 25 with subclinical hypothyroidism (SH), and 134 euthyroid subjects (E). Seven symptoms were cited by more than 70% of the patients in T and four were cited by more than 70% of subjects in ST. However, more than half of the subjects in E cited ‘heat intolerance’ and ‘easy fatigability’, indicating that these are considered as nonspecific and indefinite complaints to detect thyrotoxicosis. The mean severity of 19 symptoms was significantly higher in T than in E, and ROC analysis was moderately accurate at distinguishing T from E in four symptoms of ‘palpitation’, ‘shortness of breath’, ‘body weight loss’, and ‘tremor’.Conclusions: Four symptoms — ‘palpitation’, ‘shortness of breath’, ‘body weight loss’, and ‘tremor’ — are thought be the most useful for efficiently detecting thyrotoxicosis.
Critical Nonlocal Systems with Concave-Convex Powers
Authors: Chen Wenjing , Squassina Marco 
Published: September 2016

Abstract
By using the fibering method jointly with Nehari manifold techniques, we obtain the existence of multiple solutions to a fractional p-Laplacian system involving critical concave-convex nonlinearities, provided that a suitable smallness condition on the parameters involved is assumed. The result is obtained although there is no general classification for the optimizers of the critical fractional Sobolev embedding.
Genetic diversity and population structure of Corollospora maritima sensu lato: new insights from population genetics
Authors: Velez Patricia , Gasca-Pineda Jaime , Nakagiri Akira , Hanlin Richard T. , González María C. 
Published: September 2016

Abstract
The study of genetic variation in fungi has been poor since the development of the theoretical underpinnings of population genetics, specifically in marine taxa. Corollospora maritima sensu lato is an abundant cosmopolitan marine fungus, playing a crucial ecological role in the intertidal environment. We evaluated the extent and distribution of the genetic diversity in the nuclear ribosomal internal transcribed spacer region of 110 isolates of this ascomycete from 19 locations in the Gulf of Mexico, Caribbean Sea and Pacific Ocean. The diversity estimates demonstrated that C. maritima sensu lato possesses a high genetic diversity compared to other cosmopolitan fungi, with the highest levels of variability in the Caribbean Sea. Globally, we registered 28 haplotypes, out of which 11 were specific to the Caribbean Sea, implying these populations are genetically unique. We detected populations inhabiting human-impacted sites with null genetic variation. As long-term exposure to contaminants has been proven to decrease genetic diversity, a conservation genetics approach to assess this matter is urgent. Our results revealed the occurrence of five genetic lineages with distinctive environmental preferences and an overlapping geographical distribution, agreeing with previous studies reporting physiological races within this species.
Early neonatal pyloric stenosis after exposure to maternal macrolide therapy
Authors: Mendlovic Joseph , Picard Elie , Schimmel Michael , Hammerman Cathy , Joseph Leon 
Published: September 2016

Abstract
A case of neonatal pyloric stenosis, presenting very early in life, accompanied by massive aspiration is described. We speculate that early intrauterine exposure to maternal azithromycin therapy was linked to the disease.
Intensification of enzyme catalysed synthesis of hexyl acetate using sonication
Authors: Deshmukh Ashwini R. , Rathod Virendra K. 
Published: September 2016

Abstract
This present study focuses on ultrasound assisted process intensification of hexyl acetate synthesis via lipozyme RMIM catalysed transesterification of hexanol with triacetin by using hexane as a solvent. Hexyl acetate, an ester with fruity odor and significant green note is mostly used as flavor and fragrance material in various areas. Effect of various parameters on conversion of hexyl acetate such as molar ratio, enzyme loading, temperature, power, agitation speed and duty cycle was studied systematically. With the molar ratio of 1:1 of hexanol to triacetin with 4% enzyme loading (w/v), at agitation speed of 100 rpm with application of sonication at 60 W power and 70% duty cycle resulted in to 83% conversion at 50°C temperature in 4 h when compared with conventional method which requires 9 h for 68% conversion.
5-(N-Ethylcarbazol-3-yl)thiophene-2-carbaldehyde (ECTC): a novel fluorescent sensor for ferric ion
Authors: Zhang Qiang , Wei Huaixin , Zhai Rongjia , Ji Zhongling , Qi Yu , Zhao Xin 
Published: September 2016

Abstract
5-(N-Ethylcarbazol-3-yl)thiophene-2-carbaldehyde (ECTC), was synthesized by Suzuki coupling reaction and characterized by 1H NMR, 13C NMR and elemental analysis. This compound strongly quenches fluorescence of Fe3+ ion, whereas almost no quenching is observed in the presence of other metal ions including Na+, K+, Mg2+, Ca2+, Cu2+, Mn2+ and Co2+. Under optimized conditions, the fluorescence intensity of ECTC is quenched in a linear fashion by Fe3+ ion in a wide range of 0.1 μm–10 μm with the limit of detection below 0.1 μm.
Efficient synthesis of 4-amino-2,6-dichloropyridine and its derivatives
Authors: Ma Congming , Liu Zuliang , Yao Qizheng 
Published: September 2016

Abstract
A facile synthetic route to an important intermediate 4-amino-2,6-dichloropyridine was developed. Oxidation of 2,6-dichloropyridine as a starting material gave pyridine N-oxide derivative which was subjected to nitration followed by reduction. Subsequent nitration of the product and nucleophilic displacement reaction were carried out to afford fully substituted energetic pyridine derivatives. Most of the synthetic reactions proceeded under mild conditions.
Effect of Z Values on the Microstructure and Mechanical Properties of Post-sintered Reaction Bonded β-SiAlON
Authors: Li Yanjun , Liu Donghua , Jin Han , Ding Donghai , Xiao Guoqing , Shi Zhongqi , Jin Zhihao 
Published: September 2016

Abstract
β-SiAlON materials with different Z values (Z=0.5–3) were fabricated by a reaction bonding combining post-sintering route using raw materials of Si, Al2O3, AlN, etc. The reaction bonded β-SiAlON (RB-β-SiAlON) were post-sintered at 1,750 °C for 6 h. Apparent porosity, bulk density, bending strength and Vicker’s hardness of the samples before and after post-sintering were tested. XRD results showed that the phase composition of both RB-β-SiAlON and post-sintered RB-β-SiAlON (PSRB-β-SiAlON) were β-SiAlON. For RB-β-SiAlON, the apparent porosity was decreased with the increase of Z values, while the strength and hardness was increased accordingly. After the post-sintering procedure, nearly full densified PSRB-β-SiAlON was obtained and the mechanical properties were significantly improved. The bending strength and Vicker’s hardness of the PSRB-β-SiAlON (Z=0.5) achieved 510 MPa and 16.5 GPa, respectively, which were as 2.7 and 6.7 times high as those of the corresponding RB-β-SiAlON. However, the strength and hardness of PSRB-β-SiAlON decreased with the increase of Z value due to the grain growth.