bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Categorizing Gestational, Birth, and Neonatal Complications Following Late Pregnancy Exposure to Antidepressants:The Prenatal Antidepressant Exposure Syndrome
Authors: Gentile Salvatore 
Published: February 2017

ABSTRACTIntroduction: Late in utero exposure to antidepressants has been suspected of adversely impacting pregnancy outcome and compromising neonatal adaptation. Hence, the necessity exists to analyze published information on antidepressant use during late pregnancy to individuate potential recurrent patterns of iatrogenic complications.Methods: Computerized searches on MEDLINE, PsyclNFO, ENBASE, and Cochrane Library through February 10, 2010 were performed for selecting literature information and investigating the safety of antidepressants when used during late pregnancy.Results: Antidepressant treatment during late pregnancy may increase the rates of poor pregnancy outcome and neonatal withdrawal/ toxic reactions.Conclusions: Because both gestational complications and neonatal adverse events acknowledge the same etiology, the author suggests including such iatrogenic events under the definition of prenatal antidepressant exposure syndrome, in order to increase clinicians' awareness about the spectrum of risks which may concern the mother-infant pair when antidepressant treatment is deemed indispensable during late pregnancy.
Obsessive-Compulsive Symptom Dimensions in Japanese Tourette Syndrome Subjects
Authors: Kano Yukiko , Kono Toshiaki , Shishikura Kurie , Konno Chizue , Kuwabara Hitoshi , Ohta Masataka , do Rosario Maria Conceiçäo 
Published: February 2017

ABSTRACTObjectives: To investigate the current and lifetime frequency and severity of obsessive-compulsive (OC) symptom dimensions in Tourette syndrome (TS) patients, and how these dimensions affect clinical characteristics.Methods: Forty TS outpatients (29 males, 11 females) were interviewed with the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), the Yale Global Tic Severity Scale (YGTSS), the Shapiro Tourette Syndrome Severity Scale, and the Global Assessment of Functioning (GAF).Results: OC symptoms were present in 80% of the total sample. The miscellaneous and the symmetry dimensions were the most frequent at the “current” and “lifetime” surveys, respectively. The aggression dimension had the smallest difference between “worst ever” and current ratings among the all OC symptom dimensions. TS patients with the aggression dimension (n=7) had significantly lower scores in the GAF scale and higher frequencies of coprolalia. There were significant correlations between the YGTSS severity scores and specific DY-BOCS dimensions.Conclusion: OC symptoms are frequent in TS subjects and there were differences in the frequency, severity, and course of the OC symptom dimensions. These results emphasize the need for future longitudinal studies using a dimensional approach for the evaluation of OC symptoms in tic disorders.
Maintenance Strategies in Schizophrenia
Authors: Kane John M. 
Published: February 2017

A key consideration in the discussion of maintenance treatment in schizophrenia is how to first help bring patients to the point where acute psychopathology is sufficiently controlled, so that we can focus on consolidating the gains achieved and prevent a recurrence of illness.The different phases of treatment and response in schizophrenia include the acute phase, wherein we look for response and resolution; remission, where we control symptoms to levels of mild or less and work toward preventing relapse or any exacerbation of psychopathology; and recovery, meaning the ability to function in the community in the workplace, school, family roles, etc.In preparing patients with schizophrenia for maintenance treatment, clinicians must ensure that they have done everything possible to alleviate the acute signs and symptoms of illness to the extent possible.There are several questions to consider at this stage: How much improvement is enough? When do we change treatments, and why? What about adverse effects and the locus of care? In the context of this process of deciding how to bring about the best possible treatment response, we must consider that, if a patient is not responding, the diagnosis may need to be reevaluated. Adherence must be assessed and blood levels should be done (if feasible) to ensure that patients have an adequate amount of medication in their system. If blood levels are unavailable and adherence is an issue, the use of long-acting injectable medication should be considered. The clinician might decide to alterthe medication dose—to increase it, or perhaps decrease it if significant side effects are impeding therapeutic response. Adjunct medications or a switching strategy may be employed. Non-pharmacologic therapy, such as cognitive behavioral therapy, which can be effective at reducing symptoms of schizophrenia, should also be considered.
White Matter Hyperintensities and Their Association With Suicidally in
Major Affective Disorders: A Meta-Analysis of Magnetic Resonance Imaging
Studies
Authors: Grangeon Maria Conceição , Seixas Camila , Quarantini Lucas C. , Miranda-Scippa Angela , Pompili Maurizio , Steffens David C. , Wenzel Amy , Lacerda Acioly L. T. , de Oliveira Irismar Reis 
Published: February 2017

ABSTRACT
Introduction: Individuals who have deep and
periventricular white matter hyperintensities may have a higher risk for
suicidal behavior. There are mixed results in the literature regarding
whether unipolar or bipolar patients who have attempted suicide have more
deep white matter hyperintensities (DWMH) or periventricular
hyperintensities (PVH) relative to those who have no history of suicide
attempts.
Methods: A meta-analysis of studies examining
white matter hyperintensities (WMH) in mood disorder patients with and
without a history of suicide attempts was performed.
Results: Four studies, including a total of 173
patients who attempted suicide and 183 who did not attempt suicide, were
included. A significantly higher number of attempters were found to have WMH
than non-attempters. Unipolar depressed patients who had attempted suicide
had 1.9 times more DWMH and 2.1 times more PVH than those who did not.
Bipolar patients who had attempted suicide had 5.4 times more PVH than those
who had not. Taken together, unipolar and bipolar patients who had attempted
suicide had 2.8 times more DWMH and 4.5 times more PVH than those who had
never attempted suicide.
Insomnia in Patients With Depression: A STAR*D Report
Authors: Sunderajan Prabha , Gaynes Bradley N. , Wisniewski Stephen R. , Miyahara Sachiko , Fava Maurizio , Akingbala Felicia , DeVeaugh-Geiss Joanne , Rush A. John , Trivedi Madhukar H. 
Published: February 2017

ABSTRACT
Introduction: Insomnia symptoms, which are common
in depression, have a significant impact on function and quality of life.
However, little is known about the prevalence and associated features of
insomnia symptoms in representative treatment-seeking patients with
depression.
Methods: Data from the Sequenced Treatment
Alternatives to Relieve Depression (STAR*D) trial were analyzed. STAR*D
recruited 3,743 adult outpatients diagnosed with nonpsychotic major
depressive disorder (MDD) from primary (n=18) and psychiatric care (n=23)
clinics across the United States. Baseline sociodemographic and clinical
features were compared between those with insomnia symptoms (84.7%) and
those without (15.3%).
Results: The most common presentation was the
simultaneous presence of sleep onset, mid-nocturnal, and early morning
insomnia symptoms (27.1%). Of these three types of insomnia symptoms,
mid-nocturnal insomnia symptoms were the most commonly found alone (13.5%)
and in combination with one or more other types (82.3%). Insomnia symptoms
were associated with several indicators of a more severe depressive illness.
Only a small proportion of participants with insomnia symptoms were
receiving treatment for sleep disturbances at study initiation, and the vast
majority of those receiving treatment still reported having insomnia
symptoms.
Conclusion: In outpatients who seek treatment for
nonpsychotic MDD in typical clinical settings, insomnia symptoms are very
common, undertreated, and indicative of a more severe depression.
Interdependence of Russo-Japanese Relations and Mutual Images of Japan and Russia
Authors: CHUGROV SERGEY V. , STRELTSOV DMITRY V. 
Published: February 2017

AbstractThe current efforts of Moscow and Tokyo to unblock the territorial impasse are complicated by some barriers of a socio-psychological character, including mutual mistrust and contradictory images of past events. Public opinion surveys reveal predominant vectors in Russo-Japanese relations, which the authors believe strongly correlate with the evolution of the contradictory images. Apparently, these images surprisingly exhibit interrelated ‘mirror’ dynamics connected with the independent variable – events happening in bilateral relations. Apparently, these images surprisingly exhibit interrelated ‘mirror’ dynamics connected with the independent variable – events happening in bilateral relations. The authors also investigate how public opinion has a real impact on politics and relations between states. In the authors’ opinion, Russia and Japan definitely do not have major unresolved problems in their bilateral relations, with the exception of the territorial problem. However, why is the public so suspicious of Russia? Can the territorial dispute be the only reason? It is far from that. The analyzed arguments give grounds to believe that it is very difficult for Japan and Russia to find a mutually acceptable solution, as their relations are not free from suspicion and mutual mistrust which are deeply rooted in the history of their relations. It will be much easier to overcome the mistrust and, accordingly, to reach agreement on the territorial issue when they manage to calmly analyze the historical grudges, understand their nature and origin, and realize that this is history, which has no contemporary value.
Appraising Myanmar's Democratic Transition and Evolving Challenges
Authors: GANESAN N. 
Published: February 2017

AbstractDemocratic transitions in Asia have received widespread interest in the political science literature since the 1990s. The Thein Sein-led government that came into power in 2010 in Myanmar has undertaken wide ranging reforms that has altered the country's political landscape. They include evolving a working relationship with the political opposition, freeing political prisoners, and the granting of amnesty to political exiles to encourage their return, the negotiation of ceasefire agreements with almost all of the ethnic insurgent armies and the inauguration of the Myanmar Peace Centre. Nonetheless, the county continues to suffer from ongoing developments that retard the process of democratization as well. A confluence of interest between the NLD, ethnic groups, and civil society organizations also prompted attempts to change the 2008 Constitution and its by-laws that prevented Aung San Suu Kyi from running for the country's presidency. That attempt and the potential for reform were scuttled by the August 2015 ‘coup’ against Thura Shwe Mann. The NLD's overwhelming victory in the November elections has significantly strengthened Suu Kyi's position and all major political actors including those from the military have been conciliatory towards the election outcome and there is cause for cautious optimism. After 6 months in power, the policy priorities of the new government are also clearer.
Reforming WTO-Civil Society Engagement
Authors: HANNAH ERIN , SCOTT JAMES , WILKINSON RORDEN 
Published: February 2017

AbstractCivil society organizations are often seen as playing a crucial role in helping to mitigate the exclusion of weaker states, giving voice to marginalized communities, and raising environmental and developmental concerns within the trade system. The politicization and demystification of the global trade agenda by civil society also opens up space for a more diverse set of actors to influence trade negotiations. This article examines the evolution of the WTO secretariat's engagement with civil society within this context and argues that the dominant mode of engagement, as manifest in WTO Public Forums and civil society participation in ministerial conferences, is no longer fit for purpose. Rather it reflects an outmoded strategy that once served to underscore the existence and value of the WTO as an international organization and works to neutralize political contestation and publicly promote the benefits of free trade. It is now in need of reform.
Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation
Authors: Bohbot Véronique D. , Copara Milagros S. , Gotman Jean , Ekstrom Arne D. 
Published: February 2017

AbstractLow-Frequency Oscillations (LFO) in the range of 7–9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3–4 Hz. Here we report clear evidence of 7–9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual.
Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential
Authors: Bardot Evan , Calderon Damelys , Santoriello Francis , Han Songyan , Cheung Kakit , Jadhav Bharati , Burtscher Ingo , Artap Stanley , Jain Rajan , Epstein Jonathan , Lickert Heiko , Gouon-Evans Valerie , Sharp Andrew J. , Dubois Nicole C. 
Published: February 2017

AbstractThe recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (<5%) of the differentiated heart. These progenitors are specified during gastrulation, when they transiently express Foxa2, a gene not previously implicated in cardiac development. Importantly, Foxa2+ cells contribute to previously identified progenitor populations in a defined pattern and ratio. Lastly, we describe an analogous Foxa2+ population during differentiation of embryonic stem cells. Together, these findings provide insight into the developmental origin of ventricular and atrial cells, and may lead to the establishment of new strategies for generating chamber-specific cell types from pluripotent stem cells.
Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Authors: Harmancı Akdes Serin , Youngblood Mark W. , Clark Victoria E. , Coşkun Süleyman , Henegariu Octavian , Duran Daniel , Erson-Omay E. Zeynep , Kaulen Leon D. , Lee Tong Ihn , Abraham Brian J. , Simon Matthias , Krischek Boris , Timmer Marco , Goldbrunner Roland , Omay S. Bülent , Baranoski Jacob , Baran Burçin , Carrión-Grant Geneive , Bai Hanwen , Mishra-Gorur Ketu , Schramm Johannes , Moliterno Jennifer , Vortmeyer Alexander O. , Bilgüvar Kaya , Yasuno Katsuhito , Young Richard A. , Günel Murat 
Published: February 2017

AbstractMeningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state. Consistent with this observation, atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks. Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. Our results establish the genomic landscape of primary atypical meningiomas and potential therapeutic targets.
Three-dimensional surface topography of graphene by divergent beam electron diffraction
Authors: Latychevskaia Tatiana , Hsu Wei-Hao , Chang Wei-Tse , Lin Chun-Yueh , Hwang Ing-Shouh 
Published: February 2017

AbstractThere are only a handful of scanning techniques that can provide surface topography at nanometre resolution. At the same time, there are no methods that are capable of non-invasive imaging of the three-dimensional surface topography of a thin free-standing crystalline material. Here we propose a new technique—the divergent beam electron diffraction (DBED) and show that it can directly image the inhomogeneity in the atomic positions in a crystal. Such inhomogeneities are directly transformed into the intensity contrast in the first-order diffraction spots of DBED patterns and the intensity contrast linearly depends on the wavelength of the employed probing electrons. Three-dimensional displacement of atoms as small as 1 angstrom can be detected when imaged with low-energy electrons (50–250 eV). The main advantage of DBED is that it allows visualization of the three-dimensional surface topography and strain distribution at the nanometre scale in non-scanning mode, from a single shot diffraction experiment.
Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy
Authors: Bengtsson Niclas E. , Hall John K. , Odom Guy L. , Phelps Michael P. , Andrus Colin R. , Hawkins R. David , Hauschka Stephen D. , Chamberlain Joel R. , Chamberlain Jeffrey S. 
Published: February 2017

AbstractGene replacement therapies utilizing adeno-associated viral (AAV) vectors hold great promise for treating Duchenne muscular dystrophy (DMD). A related approach uses AAV vectors to edit specific regions of the DMD gene using CRISPR/Cas9. Here we develop multiple approaches for editing the mutation in dystrophic mdx4cv mice using single and dual AAV vector delivery of a muscle-specific Cas9 cassette together with single-guide RNA cassettes and, in one approach, a dystrophin homology region to fully correct the mutation. Muscle-restricted Cas9 expression enables direct editing of the mutation, multi-exon deletion or complete gene correction via homologous recombination in myogenic cells. Treated muscles express dystrophin in up to 70% of the myogenic area and increased force generation following intramuscular delivery. Furthermore, systemic administration of the vectors results in widespread expression of dystrophin in both skeletal and cardiac muscles. Our results demonstrate that AAV-mediated muscle-specific gene editing has significant potential for therapy of neuromuscular disorders.
Transcriptome analysis around the onset of strawberry fruit ripening uncovers an important role of oxidative phosphorylation in ripening
Authors: Wang Qing-Hua , Zhao Cheng , Zhang Miao , Li Yu-Zhong , Shen Yuan-Yue , Guo Jia-Xuan 
Published: February 2017

AbstractAlthough much progress has been made towards understanding the ripening of non-climacteric fruit using the strawberry as a model plant, the defined molecular mechanisms remain unclear. Here, RNA-sequencing was performed using four cDNA libraries around the onset of ripening, and a total of 31,793 unigenes and 335 pathways were annotated including the top five pathways, which were involved in ribosome, spliceosome, protein processing, plant-pathogen interaction and plant hormone signaling, and the important DEGs related to ripening were annotated to be mainly involved in protein translation and processing, sugar metabolism, energy metabolism, phytohormones, antioxidation, pigment and softening, especially finding a decreased trend of oxidative phosphorylation during red-coloring. VIGS-mediated downregulation of the pyruvate dehydrogenase gene PDHE1α, a key gene for glycolysis-derived oxidative phosphorylation, could inhibit respiration and ATP biosynthesis, whilst promote the accumulation of sugar, ABA, ETH, and PA, ultimately accelerating the ripening. In conclusion, our results demonstrate that a set of metabolism transition occurred during green-to-white-to-red stages that are coupled with more-to-less DEGs, and the oxidative phosphorylation plays an important role in the regulation of ripening. On the basis of our results, we discuss an oxidative phosphorylation-based model underlying strawberry fruit ripening.
Strain Dependent Electronic Structure and Band Offset Tuning at Heterointerfaces of ASnO3 (A=Ca, Sr, and Ba) and SrTiO3
Authors: Baniecki John D. , Yamazaki Takashi , Ricinschi Dan , Van Overmeere Quentin , Aso Hiroyuki , Miyata Yusuke , Yamada Hiroaki , Fujimura Norifumi , Maran Ronald , Anazawa Toshihisa , Valanoor Nagarajan , Imanaka Yoshihiko 
Published: February 2017

AbstractThe valence band (VB) electronic structure and VB alignments at heterointerfaces of strained epitaxial stannate ASnO3 (A=Ca, Sr, and Ba) thin films are characterized using in situ X-ray and ultraviolet photoelectron spectroscopies, with band gaps evaluated using spectroscopic ellipsometry. Scanning transmission electron microscopy with geometric phase analysis is used to resolve strain at atomic resolution. The VB electronic structure is strain state dependent in a manner that correlated with a directional change in Sn-O bond lengths with strain. However, VB offsets are found not to vary significantly with strain, which resulted in ascribing most of the difference in band alignment, due to a change in the band gaps with strain, to the conduction band edge. Our results reveal significant strain tuning of conduction band offsets using epitaxial buffer layers, with strain-induced offset differences as large as 0.6 eV possible for SrSnO3. Such large conduction band offset tunability through elastic strain control may provide a pathway to minimize the loss of charge confinement in 2-dimensional electron gases and enhance the performance of photoelectrochemical stannate-based devices.
Geosmin-producing Species of Coelosphaerium (Synechococcales, Cyanobacteria) in Lake Shinji, Japan
Authors: Godo T. , Saki Y. , Nojiri Y. , Tsujitani M. , Sugahara S. , Hayashi S. , Kamiya H. , Ohtani S. , Seike Y. 
Published: February 2017

AbstractIn Lake Shinji, Japan, periodic outbreaks of musty odour have occurred since mid-May 2007. Although the substance responsible for the odour was identified as geosmin, the odour-producing organism was unknown. We cultivated an axenic unialgal strain and determined that a species of Coelosphaerium (Synechococcales) was responsible for the production of geosmin in Lake Shinji. Our analysis was conducted using gas chromatography/mass spectrometry to determine the odorous compound. To determine the algae species, it was observed by optical microscopy to describe its morphological characteristics and the polymerase chain reaction was used to characterise the nucleotide sequence of the 16S rRNA gene and the 16S-23S rRNA internal transcribed spacer region. In addition, we explored the relationship between the number of cells of the Coelosphaerium sp. and the concentration of geosmin. In conclusion, geosmin, the cause of the musty odour in Lake Shinji in autumn 2009, was produced by Coelosphaerium sp., and to our knowledge, this is the first report of a geosmin-producing species in the family Coelosphaeriaceae.