bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of discospondylitis and association with congenital vertebral body malformations in English and French bulldogs
Authors: Grapes Nick , Bertram Simon , Gonçalves Rita , De Decker Steven 
Published: October 2024

AbstractBackgroundLimited current information exists regarding discospondylitis within breeds commonly affected by congenital vertebral body malformations.Hypothesis/ObjectivesReport the prevalence of discospondylitis in English and French bulldogs and investigate for possible associations of discospondylitis with congenital vertebral body malformations.Animals108 client‐owned dogs.MethodsRetrospective multi‐institutional study between June 2010 and 2020. Cases with a diagnosis of discospondylitis on computed tomography (CT) or magnetic resonance imaging (MRI) and complete medical records included. Signalment, discospondylitis location, presence of congenital vertebral body malformations, and the site of maximal kyphosis were recorded.ResultsThe prevalence of discospondylitis was 3.4 (1.6‐6.7, 95% confidence interval [CI]) times higher in French bulldogs (P < .001) and 4.3 (1.7‐9.8, 95% CI) times higher in English bulldogs (<.001), compared with the overall hospital cohort. One or more vertebral malformations were present in 12 French bulldogs (92.3%), 6 English bulldogs (75.0%), and 1 “other” breed dog (1.1%). Discospondylitis was diagnosed adjacent to congenital vertebral body malformations in 12 (80%) intervertebral discs in French bulldogs and 5 (50%) intervertebral discs in English bulldogs. The median age at presentation was significantly younger in French bulldogs (1.1 years; range, 0.5‐9.2 years) and English bulldogs (1.0 years; range, 0.4‐7.0 years), compared with “other” breed dogs (7.3 years; range, 0.3‐14.0 years; both P < .001).Conclusions and Clinical ImportanceCongenital vertebral body malformations were frequently associated with discospondylitis in French and English bulldogs, with clinical signs commonly encountered at a significantly younger age.
Islamic Medievalism and Mobility in Mathias Énard's Street of Thieves
Authors: D'Arcens Louise 
Published: October 2024

ABSTRACTSet against the backdrop of the Arab Spring uprisings, Jihadist extremism, and the neoliberal exploitation of the Global South, Mathias Énard's 2012 novel Street of Thieves (Rue des voleurs) follows the fortunes of Lakhdar, a young man from Tangier who finds himself living as an undocumented migrant in Barcelona's notorious Carrer d’En Robador, the Street of Thieves. Lakhdar's misadventures are shaped by regional and global forces which have compelled Moroccan nationals to seek political and economic asylum in Mediterranean Europe. Although Street of Thieves is strikingly contemporary, this essay explores the novel's medievalism: its contrasting of the grim present with the premodern Islamic world as an era of sophistication, mobility and cultural exchange. The essay focuses on Lakhdar's preoccupation with his fellow Tangier native Ibn Battuta, the fourteenth‐century traveler and writer whose life becomes a frame through which Lakhdar views his own. It argues that contrary to the current tendency to view Ibn Battuta's world as a precursor to modern globalised culture, Énard's novel invokes cosmopolitan Islamic premodernity to comment on the turmoil of the modern Islamosphere and the harm done to the Islamicate world by Western neo‐colonialism and neoliberalism.
Residents' perceptions of what makes feedback valuable in workplace‐based learning: A discrete choice experiment
Authors: van der Leeuw Renée M. , Bouwmeester Noor H. , Eva Kevin W. , Hiligsmann Mickaël , Teunissen Pim W. 
Published: October 2024

AbstractIntroductionResearch on feedback has shifted emphasis away from its ‘delivery’ to consideration of the interaction between individual learners and their ‘feedback provider’. The complexity inherent in determining whether feedback is perceived as valuable by learners, however, can quickly overwhelm educators if every interaction must be considered completely idiosyncratic. We, therefore, require a better understanding of variability in the ways in which feedback is perceived. To that end, we ran a discrete choice experiment aimed at determining residents' preferences and whether discernible patterns exist across learners regarding factors that influence perceptions of feedback's learning value.MethodsWe performed a discrete choice experiment in which respondents were asked to read a clinical case and select repetitively between two feedback scenarios that differed according to six attributes identified from the literature as influencing feedback credibility: Dialogue, Focus, Relationship, Situation, Source and Valence. By systematically varying the levels of each attribute contained in the scenarios and asking residents to choose which from each pair they deemed more valuable for learning, a mixed logit model and latent class analysis could be applied to determine learners' feedback preferences and whether clusters of preference exist.ResultsNinety‐five elderly care medicine residents in the Netherlands completed the questionnaire. Their responses indicated that Valence, Dialogue, Relationship and Focus each accounted for about 20% of their preferences regarding the type of feedback perceived to offer the most learning value. Source and Situation were less influential, each accounting for 11% of the choices made. A latent class model with three clusters of respondents best accounted for the heterogeneity in feedback preferences. A total of 62% of respondents could be assigned to one of the three profiles with at least 80% probability. None of the respondents' characteristics (seniority, residency programme nor sex) were related to the feedback preference profile.DiscussionOur findings suggest that ‘how’ feedback is provided has a greater influence on perceived learning value than who provides it. That said, variability exists in resident perceptions with no evidence (as yet) of factors that predict individual preferences. As such, tailoring to the needs and reactions of individual learners is likely to require open and ongoing conversations, and we recommend using the learner profiles generated through this study as a starting point because they provide classifications that could facilitate effective connections for the majority of residents.
Critical posthumanism: A double‐edged sword for advancing nursing knowledge in planetary health
Authors: Hodge Lesley A. , Olson Joanne K. 
Published: October 2024

AbstractIn this article, we aimed to evaluate the utility of critical posthumanism for nurses interested in planetary health—a growing area of study that requires a decentering of the human, and environmental justice considerations. We used Chinn and colleagues' method to describe and critically reflect on critical posthumanism, extending the theory analysis method to include a wide range of academic and video sources. We found that critical posthumanism is like a double‐edged sword: It provides a lens through which to transcend human‐centric approaches to healthcare but is marred by its lack of clarity and inaccessibility. We argue critical posthumanism can be adapted to enhance its potential at the intersection of nursing and planetary health. An analysis of critical posthumanism is followed by a discussion framed by five ways of knowing in nursing, highlighting real‐world examples of how critical posthumanism can aid nurses in dealing with planetary health concerns. By exploring the intersections of critical posthumanism with nursing knowledge, we demonstrate how critical posthumanism can enable nurses to comprehend and tackle environmental issues intricately linked to human health.
The triangular relationship in platform gig work: Consumers, platform beneficence and worker vulnerability
Authors: Healy Joshua , Pekarek Andreas 
Published: October 2024

AbstractPlatform gig work is created and contested in dynamic, triangular relationships between platforms, workers, and consumers. Compared with the first two groups, however, evidence about the role of the third—consumers—is sparse. In this paper, we investigate consumers' changing perceptions of work in the platform gig economy and argue that their perspective warrants greater attention in sociological analyses. Using data from two Australian public opinion surveys conducted 5 years apart (2017 and 2022), we explore how consumers' views of platform gig work evolved during a period of rapid change that includes the first 2 years of the COVID‐19 pandemic. We find that while overall platform use increased markedly, many consumers felt conflicted about gig workers' conditions and key features of platforms' typical labour practices. There is a pronounced, enduring, and consequential tension in consumers' views of the merits and drawbacks of this work; between, on the one hand, an acceptance that platforms do benefit workers to some extent and, on the other hand, misgivings about workers' vulnerability to harm. In centring consumers, our paper empirically enriches current triangular conceptions of labour relations in the platform gig economy, by showing how consumers mediate the interests of platforms and workers, to shape how gig work manifests and who benefits from it. We also contribute useful new practical knowledge, by elucidating the prevailing concerns of consumers that could be developed into resonant themes for campaigns aimed at improving platform gig workers' rights.
Axial length association with corneoscleral sagittal height and scleral asymmetry
Authors: Martínez‐Plaza Elena , López‐de la Rosa Alberto , Molina‐Martín Ainhoa , Bataille Laurent , Piñero David P. 
Published: October 2024

AbstractPurposeTo determine how corneoscleral geometry changes with axial length and to assess the usefulness of including the sagittal configuration of the anterior segment when predicting the axial length.MethodsAn observational study was performed including 96 healthy subjects (96 eyes). Axial length was calculated from optical biometry (IOL Master 500). Corneal curvature and scleral sagittal height parameters at 13, 14 and 15 mm were obtained automatically using corneoscleral topography (eye surface profiler; ESP). In addition, corneal and scleral sagittal heights at numerous locations (21 radii: 0–10 mm from the corneal apex at 12 angles: 0–330°) were calculated using the raw height data extracted from the ESP. The relationships between axial length and the study parameters were analysed using Pearson correlation analysis. The equations for the prediction of axial length were obtained by fitting multiple linear regression models.ResultsThe temporal‐nasal scleral asymmetry at 13‐, 14‐ and 15‐mm chord lengths was significantly correlated with axial length (r2 ≤ 0.26; p < 0.001). Significant inverse correlations were found between the temporal scleral sagittal height and axial length (r2 ≤ 0.28; p ≤ 0.02). The nasal scleral sagittal height was not associated with axial length. Three significant multiple linear regression models were fitted based on spherical equivalent, corneal radius and scleral asymmetry at 13 (r2 = 0.79; p < 0.001), 14 (r2 = 0.80; p < 0.001) and 15 (r2 = 0.80; p < 0.001) mm chord lengths.ConclusionsLarger ocular globes show reduced temporal‐nasal scleral asymmetry, mainly due to the lower sagittal height of the temporal sclera. Thus, the geometry of the temporal scleral may be a factor of interest during myopia progression.
ETHYLENE RESPONSE FACTOR6, A Central Regulator of Plant Growth in Response to Stress
Authors: Li Ting , Peng Zhen , Kangxi Du , Inzé Dirk , Dubois Marieke 
Published: October 2024

ABSTRACTETHYLENE RESPONSE FACTOR6 (ERF6) has emerged as a central player in stress‐induced plant growth inhibition. It orchestrates complex pathways that enable plants to acclimate and thrive in challenging environments. In response to various abiotic and biotic stresses, ERF6 is promptly activated through both ethylene‐dependent and ‐independent pathways, and contributes to enhanced stress tolerance mechanisms by activating a broad spectrum of genes at various developmental stages. Despite the crucial role of ERF6, there is currently a lack of published comprehensive insights into its function in plant growth and stress response. In this respect, based on the tight connection between ethylene and ERF6, we review the latest research findings on how ethylene regulates stress responses and the mechanisms involved. In addition, we summarize the trends and advances in ERF6‐mediated plant performance under optimal and stressful conditions. Finally, we also highlight key questions and suggest potential paths to unravel the ERF6 regulon in future research.
Interleukin‐27 Regulates Adaptative Immune Responses Associated With Control of Parasite Replication in Canine Leishmaniasis
Authors: dos Santos Marilene Oliveira , Costa Sidnei Ferro , Rebech Gabriela Torres , de Freitas Jéssica Henrique , Bragato Jaqueline Poleto , Soares Matheus Fujimura , Ito Lucas Takeshi Siqueira , de Rezende Eugênio Flavia , dos Santos Paulo Sérgio Patto , de Lima Valéria Marçal Felix 
Published: October 2024

ABSTRACTInterleukin 27 (IL‐27) is a cytokine that regulates susceptibility to Leishmania infantum infection in humans and experimental models. This cytokine has not yet been described in canine leishmaniasis (CanL). Therefore, we investigated whether IL‐27 has a regulatory role in CanL. The EBI3 and p28 subunits of IL‐27 were measured in splenic leukocytes culture supernatant from dogs with CanL and compared to control dogs. We also correlated EBI3 and p28 levels with IL‐21, anti‐L. infantum antibodies and parasite loads. We performed functional assays followed by IL‐27 blockade and measured parasite loads, production of cytokines in splenic leukocytes culture supernatant, and the expression of PD‐1, CTLA‐4, phospho‐Stat‐1/3, T‐bet, GATA3 and nitric oxide production (NO). Both IL‐27 subunits increased in the supernatant of dogs with CanL compared to control dogs. EBI3 and p28 levels showed a moderate positive correlation with IL‐21 (r = 0.67, p < 0.0001 and r = 0.45, p < 0.012, respectively), and the EBI3 subunit was positively associated with anti‐L. infantum IgG antibodies (r = 0.38, p < 0.040) and parasite load (r = 0.47, p < 0.009). IL‐27 and IL‐21 participate of immune responses in CanL. IL‐27 may be associated with the failure of immunity to control parasite replication via upregulation of the expression of PD‐1, CTLA‐4, T‐bet and NO in splenic leukocytes from dogs with CanL. These findings suggest that the pathways regulated by IL‐27 are involved in CanL pathogenesis in the host, and may be targets for new therapies.
Evaluation of the roles of brassinosteroid, gibberellin and auxin for tomato internode elongation in response to low red:far‐red light
Authors: Li Linge , Wonder Jesse , Helming Ticho , van Asselt Gijs , Pantazopoulou Chrysoula K. , van de Kaa Yorrit , Kohlen Wouter , Pierik Ronald , Kajala Kaisa 
Published: October 2024

AbstractIn this study, we explore the interplay between the plant hormones gibberellins (GA), brassinosteroids (BR), and Indole‐3‐Acetic Acid (IAA) in their collective impact on plant shade avoidance elongation under varying light conditions. We focus particularly on low Red:Far‐red (R:FR) light conditions achieved by supplementing the background light with FR. We characterized the tomato internode response to low R:FR and, with RNA‐seq analysis, we were able to identify some of the potential regulatory hormonal pathways. Through a series of exogenous pharmacological modulations of GA, IAA, and BR, we demonstrate that GA and BR are sufficient but also necessary for inducing stem elongation under low R:FR light conditions. Intriguingly, while IAA alone shows limited effects, its combination with GA yields significant elongation, suggesting a nuanced hormonal balance. Furthermore, we unveil the complex interplay of these hormones under light with low R:FR, where the suppression of one hormone's effect can be compensated by the others. This study provides insights into the hormonal mechanisms governing plant adaptation to light, highlighting the intricate and adaptable nature of plant growth responses. Our findings have far‐reaching implications for agricultural practices, offering potential strategies for optimizing plant growth and productivity in various lighting environments.
Unveiling and explaining the procedural justice in the policy design of renewable energy siting process in the United States
Authors: Gao Xue , Zhou Shan , Schurr Dori 
Published: October 2024

AbstractSocial justice is a fundamental value in public policy, but empirically examining this intricate concept remains a persistent challenge. Recent studies have made early attempts to examine how policy design choices consider distributive justice but have overlooked how procedural justice considerations have been integrated into policy designs. Drawing on policy design and participatory governance literature, this study develops a procedural justice score to empirically measure and compare policy design features of renewable energy siting policies across U.S. states. We focus on policy goals, settings, and calibrations of policy instruments, and the congruence between policy goals and instruments. We do not find consistent policy congruence, which implies that policymakers can view procedural justice as both a normative goal associated with democratic ideals and an instrumental goal facilitating a successful and sustainable energy transition. While most states fall short in designing a fair, inclusive, and participatory process, there is a growing trend toward adopting participatory approaches in renewable siting.
Impact of gluten intake on clinical outcomes in patients with chronic inflammatory diseases initiating biologics: Secondary analysis of the prospective multicentre BELIEVE cohort study
Authors: Gregersen Laura , Jessen Pernille Dyhre , Lund Helene Wiencke , Overgaard Silja Hvid , Hikmat Zainab , Ellingsen Torkell , Kjeldsen Jens , Pedersen Andreas Kristian , Petersen Sofie Ronja , Jawhara Mohamad , Nexøe Anders Bathum , Bygum Anette , Hvas Christian Lodberg , Dahlerup Jens Frederik , Bergenheim Frederik Olof , Glerup Henning , Henriksen Rikke Holm , Guldmann Tanja , Hvid Lone , Brodersen Jacob , Munk Heidi Lausten , Pedersen Natalia , Saboori Sanaz , Nielsen Ole Haagen , Heitmann Berit Lillenthal , Haldorsson Thorhallur Ingi , Christensen Robin , Andersen Vibeke 
Published: October 2024

AbstractChronic inflammatory diseases (CIDs) pose a growing healthcare challenge, with a substantial proportion of patients showing inadequate response to biological treatment. There is renewed interest in dietary changes to optimize treatment regimens, with a growing body of evidence suggesting beneficial effects with adherence to a gluten‐free diet. This study compared the likelihood of achieving clinical response to biological treatment after 14–16 weeks in patients with CID with high versus low‐to‐medium gluten intake. Secondary outcomes of interest included changes in disease activity, health‐related quality of life and C‐reactive protein. The study was a multicentre prospective cohort of 193 participants with a CID diagnosis (i.e. Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis or Psoriasis) who initiated biological treatment between 2017 and 2020. Participants were stratified based on their habitual gluten intake: the upper 33.3% (high gluten intake) and the remaining 66.6% (low‐to‐medium gluten intake). The proportion of patients achieving clinical response to biological treatment after 14–16 weeks was compared using logistic regression models. The median gluten intake differed significantly between groups (12.5 g/day vs. 5.9 g/day, standardized mean difference = 1.399). In total, 108 (56%) achieved clinical response to treatment, with no difference between 35 (55%) in the high gluten group and 73 (57%) in the medium‐to‐low gluten group (OR = 0.96 [0.51–1.79], p = 0.897). No differences were found with secondary outcomes. In conclusion, this study found no association between gluten intake and response to biological treatment in patients with CID.
How do we manage hyperhemolysis syndrome
Authors: Adkins Brian D. , Kaylani Samer Z. , Nero Alecia , Ibrahim Ibrahim F. , Shen Yu‐Min , Sarode Ravindra 
Published: October 2024

AbstractBackgroundHyperhemolysis syndrome (HHS) is a catastrophic anemia characterized by destruction of both donor and patient red blood cells (RBC). HHS occurs after transfusion and can cause significant morbidity and mortality. Given the difficulty in diagnosing and managing this process, we provide a detailed overview of our treatment protocol.Study Design and MethodsMembers of the Transfusion Medicine and Hematology faculty at our institution collaborated in an iterative process to produce a consensus approach to patients with HHS.ResultsWe present diagnostic criteria for HHS: recent transfusion within past 7 days (up to 21 days), rapid hemoglobin decline to below the pretransfusion level (usually hemoglobin drop >25% from pretransfusion), a significant decrease in HbA% (in patients with sickle cell disease or beta thalassemia), low or decreasing reticulocyte count in a patient with worsening anemia, and laboratory evidence of hemolysis. We also describe an in‐depth approach to management focusing on optimizing hematopoiesis while dampening the immune response.ConclusionWe provide a comprehensive approach to the diagnosis and management of HHS based on contemporary literature and clinical experience designed to optimize outcomes for patients.
Reducing unnecessary outpatient group and screen testing at a regional cancer center
Authors: VanderMeulen Heather , Gupta Akash , Buckstein Rena , Kennedy James A. , Colavecchia Connie , Viveiros Jami‐Lynn , Lin Yulia 
Published: October 2024

AbstractBackgroundUnnecessary group and screens (G&S) can lead to unnecessary antibody investigations, use of technologist time, and laboratory resources.Local ProblemA baseline audit at our institution identified that 25% of G&S from the cancer center were unnecessary. We aimed to reduce the ratio of monthly G&S to CBC samples processed from the cancer center by 10% (from 0.034 to 0.031) by January 2024.MethodsThis represents an interrupted time series design from November 2022 to January 2024. Using Plan Do Study Act (PDSA) cycles, we aimed to increase the use of an existing reflex testing system, termed “do not test.” When this option is selected, the blood bank will only process the G&S sample if specific CBC criteria are met (e.g., hemoglobin <9.0 g/dL). Educational sessions increased awareness of this feature and sought feedback from end‐users on its usability. With feedback, the design was updated to include a modifiable hemoglobin threshold for G&S testing, automatic re‐selection of the “do not test” feature for future G&S orders, and aesthetic changes to make the feature more visible.ResultsThe percentage of samples with “do not test” selected increased from 7.2% to 63.0% (p < .0001) and the ratio of G&S to CBC specimens improved from 0.034 to 0.028, exceeding the target of 0.031. We noted an improvement in the appropriateness of G&S orders from 75% at baseline (n = 20) to 97.5% (n = 80) post intervention (p = .003).ConclusionsWe describe an effective strategy to improve G&S utilization at our institution's cancer center using a reflex testing system.