bluuebunny/crossref_metadata_2025_split huggingface dataset:
The K2 and TESS Synergy. III. Search and Rescue of the Lost Ephemeris for K2's First Planet
Authors: Thygesen Erica , Rodriguez Joseph E. , de Beurs Zoë L. , Vanderburg Andrew , Livingston John H. , Irwin Jonathon , Venner Alexander , Cretignier Michael , Collins Karen A. , Bieryla Allyson , Charbonneau David , Crossfield Ian J. M. , Dumusque Xavier , Kielkopf John , Latham David W. , Werner Michael 
Published: September 2024

Abstract
K2-2 b/HIP 116454 b, the first exoplanet discovery by K2 during its Two-Wheeled Concept Engineering Test, is a sub-Neptune (2.5 ± 0.1 R
⊕, 9.7 ± 1.2 M
⊕) orbiting a relatively bright (K

S
= 8.03) K-dwarf star on a 9.1 day period. Unfortunately, due to a spurious follow-up transit detection and ephemeris degradation, the transit ephemeris for this planet was lost. In this work, we recover and refine the transit ephemeris for K2-2 b, showing a ∼40σ discrepancy from the discovery results. To accurately measure the transit ephemeris and update the parameters of the system, we jointly fit space-based photometric observations from NASA’s K2, Transiting Exoplanet Survey Satellite, and Spitzer missions with new photometric observations from the ground, as well as radial velocities from HARPS-N that are corrected for stellar activity using a new modeling technique. Ephemerides becoming lost or significantly degraded, as is the case for most transiting planets, highlights the importance of systematically updating transit ephemerides with upcoming large efforts expected to characterize hundreds of exoplanet atmospheres. K2-2 b sits at the high-mass peak of the known radius valley for sub-Neptunes, and is now well-suited for transmission spectroscopy with current and future facilities. Our updated transit ephemeris will ensure no more than a 13 minute uncertainty through 2030.
Brazilian Transnational Normative Entrepreneurship on RWP and welcoming of Venezuelan Refugees
Authors: Vieira de Siqueira Estela Cristina , Krupp da Luz Cícero 
Published: September 2024

The present study aims to analyze the gap between the position of the International Relations of the Federative Republic of Brazil towards the conceptual enlargement of the institute of the Responsibility to Protect (R2P) to Responsibility while Protecting (RwP), practiced while addressing the case of Muammar Gaddafi’s Libya, towards the current situation of Venezuelan refugees on Brazilian borders and the judicial decision on closing borders, appreciated at appeal level by the regional section of Federal Justice in Brazil. Brazilian Foreign Relations, in an exercise of normative entrepreneurship, presented Responsibility while Protecting as an alternative to R2P, in the sense that, as humanitarian intervention shall be taken as ultima ratio, measures to reestablish peace and development in affected States must be a priority of action on an international level, deviating from the use of force. However, in a moment when a neighboring country goes through a political crisis that attracts the attention of great powers to the possibility of intervening, Brazil fluctuates between positioning itself favorably to the welcoming of refugees and, at the same time, judicially closing borders. Thus, it might be that RwP can be considered as a mere exercise of political theory an international level. The position the Brazilian State adopts when the responsibility while protecting – an institute of Brazilian initiative – crosses our borders is somewhat different from its discourse towards it.
Botulinum toxin-A in acute acquired comitant esotropia during COVID pandemic in children and young adolescents
Authors: Pawar Neelam , Shyam Praveena , Ravindran Meenakshi , Allapitchai Fathima 
Published: September 2024

Purpose:
To study the effectiveness of botulinum toxin A (BTX-A) in the treatment of patients with acute acquired comitant esotropia (AACE) due to excessive use of mobile and laptops in the COVID era in the pediatric population and adolescents.

Methods:
This was a retrospective, interventional study of pediatric patients and young adults who presented with AACE and received unilateral or bilateral BTX-A. All the patients complained of binocular diplopia and sudden onset of esotropia with a history of mobile or laptop usage during the COVID era (2020–2023). Twenty-seven patients with acute-onset esotropia in 3 years (2020–2023) were included. All patients were administered 2.5–7.5 units of BTX-A (Botox, Allergan, India) into the unilateral or bilateral medial rectus muscle of the deviating eye under short general anesthesia or local anesthesia. The main outcome measures were pre- and post-injection angle of deviation, pre- and post-injection stereopsis, final level of stereopsis achieved, recurrence, and whether strabismus surgery was later required.

Results:
The mean age of patients was 12.85 ± 7.15 years (range: 4–25 years). The mean dosage of Botox was 6 U (2.5–7.5 U). The mean follow-up was 6 months (6 months–2 years). The mean preoperative angle of deviation (AOD) was 41.11 ± 10.9 prism diopters (PD) for distance and 41.67 ± 10.9 PD for near. The maximum effect of BTX-A was seen at 1 month; post-injection AOD was 13.65 ± 14.7 PD for distance and 14.87 ± 15.8 PD for near (P < 0.001). Over half of the patients achieved optimal outcomes, with improvements in stereopsis and sensory fusion. Early intervention (within 3 months of symptom onset) significantly correlated with treatment success.

Conclusion:
While BTX-A therapy for acute-onset esotropia demonstrates efficacy, patient-specific considerations are essential. This study highlights the evolving nature in the digital age and early administration of BTX-A along with close follow-up to monitor residual and recurrence of esotropia. The surgical intervention can increase the final success rate.
Incidence, etiology, and risk factors for tube explantation in patients undergoing patch-free glaucoma drainage device
Authors: Senthilkumar Vijayalakshmi A , Akbar Umme Salma , Rajendrababu Sharmila 
Published: September 2024

Purpose:
To report the incidence, etiology, and risk factors for tube explantation in patients undergoing patch-free glaucoma drainage device (GDD).

Methods:
Of the total 1303 patients who underwent patch-free GDD (703 non-valved GDD and 600 valved GDD) for refractory glaucoma during January 2020–October 2023, we identified five cases of postoperative complications following GDD that required tube or shunt removal.

Results:
Median (IQR) age of our study cohorts was 54.5 (8–66) years. The incidence of tube exposure and tube explantation was 0.003% and 0.004%, respectively. The median time interval for tube or plate explantation from the time of GDD surgery was 11.5 (2–16) months. The diagnoses of refractory glaucoma for which GDD was performed were secondary glaucoma following multiple vitreoretinal (VR) surgery (60%), primary open-angle glaucoma (20%), and aphakic glaucoma (20%). Of these, two patients (40%) presented with recurrent tube exposures, two patients (40%) with tube exposure and early endophthalmitis, and one patient (20%) with persistent hypotony. Four patients (80%) had undergone non-valved Aurolab aqueous drainage implant and one underwent (20%) Ahmed glaucoma implant. Three patients (60%) had diabetes mellitus with a history of multiple VR surgical intervention. GDD explantation was done in three patients (60%), and the remaining two patients (40%) required only tube amputation. One patient presented with orbital cellulitis, and there was no culture growth seen in any of our study cohorts.

Conclusion:
Tube and plate exposures pose a significant risk for potential infections and warrant prompt explantation of GDD to avoid endophthalmitis. Previous history of multiple VR surgeries, diabetes mellitus, and non-valved implants were the common risk associations noted for tube exposures in our retrospective study.
Vulnerabilidade as Inundações, Abordagens Metodológicas de Avaliação e Ações para a Resiliência
Authors: Chicombo Tomé Francisco , Moreira Alecir Antônio Maciel 
Published: September 2024

Este artigo traz uma reflexão sobre a vulnerabilidade às inundações, seus diversos componentes, abordagens metodológicas, escalas de análise e principais medidas para a construção da resiliência. O estudo baseou-se em revisão teórico-conceitual como método para a sua elaboração. Constatou-se que quatro principais abordagens são usadas quando se trata de avaliação da vulnerabilidade às inundações, a saber: as curvas de vulnerabilidade, matrizes de danos, indicadores de vulnerabilidade e abordagens baseadas na modelagem. Essas abordagens adotam escalas de análise que variam da realidade micro à nacional, passando pela local e regional. A construção de medidas que conduzem à resiliência deve atender a vários domínios, onde se destacam o físico-ambiental, o social, o econômico, o socio-comportamental e o politico-administrativo, todos abordados de forma integrada. A principal conclusão deste estudo é que as abordagens de avaliação às inundações devem sempre ter como base de análise: o contexto no qual elas ocorrem e a vulnerabilidade como caraterística intrínseca de um sistema ou elemento. Por outro lado, a adoção das estratégias de adaptação deve ser realizada de forma holística e integrada, atentando-se para a forma com que cada fator contribui particularmente para acentuação da vulnerabilidade em comunidades.
Kasih yang Benar: Sebuah Analisis Roma 13: 8-14 di Tengah Kehidupan Orang Percaya
Authors: Setiawan Iwan , Hillasterion Alfa Chrisen , Simarmata Christian Marlen Firuli , Maelite Juldistriani Amisha Diana , Katue Marni 
Published: September 2024

Jesus was a great teacher who set an example of humility, especially in teaching love to His students in various ways or methods. Love is very easy to say, it is easy to explain good theories about love, but in reality, good theories are not balanced with good life practices. The research method that the author uses is a qualitative approach with a descriptive method, explaining it in a hermeneutic way, namely a method that expresses, translates, and interprets. The source material is the biblical text to gain an understanding of the biblical text. The research aims to discover the principles of love contained in Romans 13: 8-14, to provide a deep understanding of this text so that believers can implement love correctly. The result of his research is Jesus as the Foundation of Love. Jesus Christ is the armor of light, wearing the Lord Jesus. The correct attitude of love is don’t owe anything, love each other, love your neighbor as yourself, don't commit adultery, don't kill, don't steal, don't covet and any other word, love doesn't do evil to fellow human beings because love is the fulfillment of the law. The action is to continue living in Love because time is getting shorter by having to wake up from sleep, put off the deeds of darkness put on the armor of light, and live according to God's will. Yesus adalah guru agung yang memberikan teladan kerendahan hati terkhusus dalam mengajarkan tentang kasih kepada murid-murid-Nya dengan berbagai cara atau metode. Kasih sangat mudah untuk diucapkan, mudah untuk menjelaskan teori-teori yang baik mengenai kasih, tetapi pada kenyataanya teori yang baik itu tidak diimbangi dengan praktek hidup yang baik pula. Metode penelitian yang penulis gunakan adalah pendekatan kualitatif dengan metode deskriptif, menguraikannya dengan cara hermeneutik yaitu sebuah metode yang mengekpresikan, menterjemahkan dan menafsirkan. Sumber bahannya adalah teks Alkitab dengan tujuan untuk memperoleh pemahaman dari teks alkitab. Tujuan penelitian adalah untuk menemukan prinsip-prinsip kasih yang terdapat dalam Roma 13: 8-14, supaya memberikan pemahaman yang mendalam mengenai teks ini sehingga orang percaya dapat mengimplementasikan kasih secara benar. Hasil penelitiannya adalah Yesus sebagai Dasar Kasih. Yesus Kristus sebagai perlengkapan senjata terang, mengenakan Tuhan Yesus. Sikap Kasih yang benar yaitu jangan berhutang apa-apa, saling mengasihi, mengasihi sesama seperti diri sendiri, jangan berzinah, jangan membunuh, jangan mencuri, jangan mengingini dan firman lain manapun juga, kasih tidak berbuat jahat terhadap sesama manusia karena kasih adalah kegenapan hukum taurat. Tindakan untuk terus hidup dalam Kasih karena waktu yang semakin singkat dengan harus bangun dari tidur, menanggalkan perbuatan-perbuatan kegelapan dan mengenakan perlengkapan senjata terang dan hidup sesuai kehendak Tuhan.
Novel drug combinations suggested for treating pancreatic cancer
Authors: Elazar Meyer 
Published: September 2024

Pancreatic cancer (PC) is a type of gastrointestinal tumor with poor anticipation and high level of death rate, being a fatal disease in which the overall 5-year survival rate is less than 4%1. PC poorly responds to most chemotherapeutic agents and the main current systemic chemotherapy treatments for patients with advanced disease are the drug combinations FOLFIRINOX and gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (Abraxane). Therefore, there is a profound world-wide unmet medical need for new drug combination treatments having significant positive impact on the survival and day-to-day functioning of PC patients. It is suggested herein that treatment of drug combinations of bevacizumab plus bortezomib or dacarbazine and decitabine and optionally interferon α can be beneficial for patients suffering from locally advanced and metastatic PC, subject to creating predictive models to determine possible drug resistance and receiving positive results in clinical trials.
PERANAN KEPOLISIAN DALAM UPAYA MENANGGULANGI JUDI ONLINE (Studi Penelitian di Kepolisian Resor Deli Serdang)
Authors: Miranda Bagus , Lubis Yamin , Purba Ahmad Rusly 
Published: September 2024

Judi melalui internet (internet gambling) biasanya terjadi karena peletakan taruhan pada kegiatan olah raga atau kasino melalui internet. Pelaku judi online tersebut dapat dipidana berdasarkan Pasal 27 ayat (2) jo. Pasal 45 ayat (2) Undang-Undang Nomor 19 Tahun 2016 tentang Informasi dan Transaksi Elektronik. Rumusan masalah dalam penelitian dalam tesis ini adalah bagaimana pengaturan hukum tindak pidana perjudian online yang berlaku di Indonesia, bagaimana peran kepolisian dalam menanggulangi judi online di wilayah hukum Kepolisian Resor Deli Serdang, bagaimana hambatan Kepolisian Resor Deli Serdang dalam menanggulangi judi online. Metode penelitian yang digunakan adalah deskriftif analisis yang mengarah pada penelitian hukum yuridis normatif dan yuridis empiris yakni penelitian yang dilakukan dengan cara mengacu pada norma-norma hukum yaitu meneliti terhadap bahan pustaka atau bahan sekunder dan penelitian lapangan. Hasil pembahasan menyimpulkan bahwa hambatan penegakan hukum oleh unit Cyber Crime Ditreskrimsus Polda yaitu sanksi pidana terhadap judi online berdasarkan Pasal 45 UU ITE lebih rendah dari ancaman sanksi pidana dalam Pasal 303 KUHP, Upaya untuk mengatasi hambatan tersebut adalah penerapan KUHP dan UU ITE dalam perkara judi online harus mengedepankan asas lex specialis derogat legi generalis, mengadakan pelatihan bimbingan teknologi informasi.
ANALISIS YURIDIS WANPRESTSI DALAM PELAKSANAAN PERJANJIAN PENGADAAN BARANG DAN JASA DI PT. PERKEBUNAN NUSANTARA IV REGIONAL I PABRIK KERNEL OIL SEI MANGKEI
Authors: Siregar Akhirmen , Akhyar Adil , Mukidi Mukidi 
Published: September 2024

Lembaga Kebijakan Pengadaan Barang/Jasa Pemerintah yang selanjutnya disingkat LKPP adalah lembaga Pemerintah yang bertugas mengembangkan dan merumuskan kebijakan Pengadaan Barang/Jasa Pemerintah. Permasalahan dalam penelitian ini adalah bagaimana pengaturan hukum pelaksanaan perjanjian pengadaan barang dan jasa antara CV.Mutu Utama dengan PT Perkebunan Nusantara IV Regional I Pabrik Kernel Oil Sei Mangkei, bagaimana akibat hukum terjadinya wanprestasi dalam perjanjian pengadaan barang dan jasa oleh CV.Mutu Utama terhadap di PT Perkebunan Nusantara IV Regional I Pabrik Kernel Oil Sei Mangkei, bagaimana penyelesaian akibat wanprestasi oleh CV.Mutu Utama dalam perjanjian pengadaan barang dan jasa di PT Perkebunan Nusantara IV Regional I Pabrik Kernel Oil Sei Mangkei. Penelitian yang dilakukan adalah penelitian yuridis normatif dan empiris yaitu menganalisis peraturan perundang-undangan dihubungkan dengan permasalahan dalam tesisi ini dan analisis data yang digunakan adalah data kualitatif. Berdasarkan hasil penelitian dipahami bahwa pengaturan hukum pelaksanaan perjanjian pengadaan barang dan jasa antara PT Perkebunan Nusantara IV Regional I Pabrik Kernel Oil Sei Mangkei dengan CV.Mutu Utama diatur berdasarkan Peraturan Lembaga Kebijakan Pengadaan Barang/Jasa Pemerintah Republik Indonesia Nomor 8 Tahun 2022 Tentang Perubahan Atas Peraturan Lembaga Kebijakan Pengadaan Barang/Jasa Pemerintah Nomor 6 Tahun 2021 Tentang Pedoman Penyusunan Dan Pengelolaan Rencana Aksi Pemenuhan Pengelola Pengadaan Barang/Jasa.
Gender Pedagogy: Developing Champion Educational Leaders in East Africa
Authors: Wango Nyagwegwe Chaulo , Rarieya Jane Frances Akinyi , Biswalo Tage Anthony 
Published: September 2024

Purpose: This study explored the landscape of educational leadership development in East Africa. It investigated its ability to equip leaders with the knowledge, skills, and attitudes necessary to promote gender-responsive and inclusive practices.
Methodology: Employing a mixed-methods approach, this study collected data through surveys, interviews, and document analysis across Kenya, Tanzania, and Uganda. The participants included educational leaders, local government authorities, and other stakeholders. Quantitative and qualitative data analyses were performed.
Findings: The findings are as follows: Effective sensitization meetings foster shared understanding and ownership of gender-responsive initiatives, and teacher colleges can play a vital role by offering targeted training. Some knowledge gaps exist, necessitating targeted training of educational leaders and Local Government Administrators on gender responsiveness and inclusion.
Unique Contribution to Theory, Policy, and Practice: The study recommends establishing multi-stakeholder collaboration and dialogue platforms and designing context-specific sensitization meetings tailored to local communities and leaders. Furthermore, strengthening college support through targeted training and programs focused on gender-responsive leadership and pedagogy is necessary. Additionally, investment in training to address knowledge gaps and equip leaders with the necessary skills and tools to facilitate collaborative action research and knowledge sharing for continuous learning and improvement. By implementing these recommendations, East Africa can cultivate a generation of educational leaders who champion gender equality and inclusivity, creating more equitable and transformative learning environments.
Analisis Prosedur Penyusunan Anggaran Operating Cost The Reiz Suites Artotel Curated Medan
Authors: Emi Emilia Contesa Lubis , Tambun Rosmaida 
Published: September 2024

This study aims to analyze the operating cost budgeting procedure at The Reiz Suites Artotel Curated Medan. The study was conducted using a case study method to deeply understand the budgeting process at the hotel. Primary data was obtained through interviews with financial managers and related staff, while secondary data was obtained from the company's internal documentation. Analysis was carried out on the stages of budgeting, factors that influence cost estimates, and cost control strategies implemented by management. The results of the study obtained include factors that influence the preparation of the operating cost budget at The Reiz Suites Artotel Curated Medan, namely internal factors, which include price estimates taken from digital marketing and the determination of the company's revenue target must increase but still with excellent service, as well as external factors that include competitive conditions in facilities in the hotel industry which are increasingly increasing.
Keywords: Budgeting, Procedures, Operating Costs

Abstrak
Penelitian ini bertujuan untuk menganalisis prosedur penyusunan anggaran operating cost pada The Reiz Suites Artotel Curated Medan. Penelitian dilakukan dengan metode studi kasus untuk memahami secara mendalam proses penyusunan anggaran di hotel tersebut. Data primer diperoleh melalui wawancara dengan manajer keuangan dan staf terkait, sedangkan data sekunder diperoleh dari dokumentasi internal perusahaan. Analisis dilakukan terhadap tahapan penyusunan anggaran, faktor-faktor yang memengaruhi estimasi biaya, serta strategi pengendalian biaya yang diterapkan oleh manajemen. Hasil penelitian yang diperoleh antara lain faktor-faktor yang mempengaruhi penyusunan anggaran operating cost The Reiz Suites Artotel Curated Medan adalah faktor internal, yang meliputi estimasi harga diambil dari digital marketing serta penetapan target revenue perusahaan harus meningkat namun tetap dengan excellent service, serta faktor eksternal yang meliputi kondisi persaingan dalam fasilitas pada industri perhotelan yang semakin meningkat
Kata Kunci: Anggaran, Prosedur, Biaya Operasional
Implementasi Kebijakan Penyusunan Anggaran Pendapatan dan Belanja Daerah pada Kota Sawahlunto
Authors: Rafizon Delka , Ariany Ria 
Published: September 2024

The purpose of this study is to determine the Implementation of the Regional Revenue and Expenditure Budget preparation policy of Sawahlunto City in Fiscal Year 2023. The method used is a descriptive method with a qualitative approach. Information obtained through observation techniques and interviews to the Sawahlunto City Government Budget Team and the Regional People's Representative Council Budget Agency. The study used the Merilee S. Grindle policy implementation model. The results obtained that the need for increased resources and the selection of appropriate programs and activities to improve the economy in the future.

Abstrak
Tujuan penelitian ini adalah untuk mengetahui implementasi kebijakan penyusunan Anggaran Pendapatan dan Belanja Daerah Kota Sawahlunto Tahun Anggaran 2023. Metode yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Informasi diperoleh melalui teknik observasi dan wawancara, kepada Tim Anggaran Pemerintah Kota Sawahlunto dan Badan Anggaran Dewan Perwakilan Rakyat Daerah. Penelitian menggunakan model implementasi kebijakan Merilee S. Grindle. Hasil diperoleh bahwa perlunya peningkatan sumber daya dan pemilihan program dan kegiatan yang tepat untuk peningkatan perekonomian di masa yang akan datang.
Medicamentos de alto precio: un problema de Derechos Humanos para la salud pública global
Authors: Braga Menéndez Florencia 
Published: September 2024

Los editores de la Revista del Hospital Italiano de Buenos Aires les propone a nuestros lectores la oportunidad de reflexionar sobre temas que se encuentran en debate en la comunidad científica. Para ello hemos invitado a exponer sus posiciones sobre la cobertura de medicación de alto costo a dos prestigiosos referentes del tema con miradas contrapuestas a partir de una situación clínica. A continuación les compartimos las reflexiones del Dr. Carlos García y la Lic. Elizabeth Braga menéndez a partir del siguiente escenario hipotético:
El responsable de salud de una localidad recibe la solicitud de cobertura de una medicación de alto costo para el tratamiento de una enfermedad degenerativa en un niño de 4 años.
Se trata de una medicación cuya aprobación está siendo considerada por la Food and Drug Administration (FDA) de los Estados Unidos y ha demostrado ser segura y retrasar en 4 meses la pérdida de pautas madurativas en forma significativa, pero no modifica el mal pronóstico evolutivo de la enfermedad.
La comunidad se encuentra muy afectada por la situación de la familia, y los medios de comunicación están pendientes de las novedades relativas al caso.