bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newly qualified teachers’ professional learning through practitioner enquiry
Authors: Robson Dean , Mtika Peter 
Published: July 2017

Purpose
The purpose of this paper is to focus on a partnership-based mentoring model and the learning experiences of participant mentees and mentors. As part of the project, newly qualified teachers (NQTs) were supported to develop and implement a practitioner enquiry (teacher/action research) in a learning community involving two local authorities and an initial teacher education institution.

Design/methodology/approach
Qualitative data were collected from five semi-structured focus group interviews with key participant groupings to uncover perceptions and experiences of the partnership and professional learning therein. Analysis using an inductive and iterative approach pinpointed a number of emerging themes used to frame key elements of the findings.

Findings
Findings suggested that the partnership-based model promoted the professional learning and development of NQTs and their mentors in various ways. The nature and shape of the partnership had an influence on the quality of mentoring and support experienced. The community effectively supported the implementation of meaningful enquiry projects, which had clear connections to the enhancement of professional practice and pupil learning. However, specific tensions and conflicts emerged as hindrances to successful partnership-based mentoring in the specific context.

Originality/value
New insights into the role of a partnership-based mentoring scheme supporting practitioner enquiry-based learning of NQTs emerged. The local, layered community defining the partnership, and operating within the frame of a national induction scheme, was analysed. Benefits for partners were identified and specific challenges and tensions highlighted, both providing new evidence with potential to impact policy and practice. Policy developments supporting teachers to be mentors and enquiring professionals need to recognise the structural and support tensions that exist in contextual practice.
International e-commerce for fashion products: what is the relationship with performance?
Authors: Macchion Laura , Moretto Antonella Maria , Caniato Federico , Caridi Maria , Danese Pamela , Vinelli Andrea 
Published: July 2017

Purpose
The purpose of this paper is to analyse whether the adoption of e-commerce improves company business, innovation and operational performance and whether sales internationalisation might moderate this relationship.

Design/methodology/approach
The research is based on a survey within the fashion industry and a multi-step linear regression model investigating the relationships between e-commerce and performance.

Findings
Results reveal that e-commerce improves innovation performance but has no significant relationship with business and operational performance. Also investigating whether the sales internationalisation might moderate the relationship between e-commerce and performance, the findings reveal that the adoption of these tools might even be negative when applied at the international level in particular by considering innovation operational practices, and the research suggests for fashion companies the necessity to develop strong markets’ knowledge and brand awareness among foreign markets and customers before investing internationally.

Originality/value
This paper offers an original analytical approach to identifying the relationships between a company’s adoption of e-commerce, performance and internationalisation within the fashion industry.
Categorising the money management behaviour of young consumers
Authors: Bamforth Jill , Geursen Gus 
Published: July 2017

PurposeYoung consumers represent a significant purchasing group, but little is known about how they make money management decisions. This study aims to identify and classify different approaches to money management that may impact purchasing behaviour.Design/methodology/approachData from focus groups with 40 respondents between 18 and 24 years were recruited via campus notices across three campuses in a university in Melbourne, Australia.FindingsBased on how respondents accommodated economic, social and psychological influences in their money management approach, the authors identified three distinct approaches to money management: conservative money managers, creative money managers and entrepreneurial money managers.Research limitations/implicationsThe study is based on a small sample consisting of 40 individuals in Australia.Practical implicationsYoung consumers share common traits as a group but have diverse attitudes and approaches to money management. The authors identify three distinct approaches to money management based on respondents’ management of factors affecting their money management. Companies must consider these differences to effectively approach millennial consumers.Social implicationsThe indebtedness of young consumers is a common concern in society. Analysis of their approaches to money management offers an opportunity for organisations to support responsible individual money usage amongst young consumers.Originality/valueWhile exploratory, the current study is the first to consider how differences in money management behaviour in young generations may impact consumer decision-making.
Letter: sprue‐like enteropathy associated with angiotensin II receptor blockers other than olmesartan
Authors: Zanelli M. , Negro A. , Santi R. , Bisagni A. , Ragazzi M. , Ascani S. , De Marco L. 
Published: July 2017

Linked ContentThis article is linked to Zanelli and Negro et al and Marthey and Carbonnel papers. To view these articles visit https://doi.org/10.1111/apt.14176 and https://doi.org/10.1111/apt.14191.
Letter: there's something about the Neutrophil‐to‐Lymphocyte ratio (NLR)…
Authors: Forrest E. H. 
Published: July 2017

Linked ContentThis article is linked to Forest and Cai and Shi et al papers. To view these articles visit https://doi.org/10.1111/apt.14183 and https://doi.org/10.1111/apt.14208.
Editorial: migration studies to determine risk and cause of inflammatory bowel disease
Authors: Kuenzig M. E. , Benchimol E. I. 
Published: July 2017

Linked ContentThis article is linked to Kuenzig and Benchimol and Dasmas and Schwarts et al papers. To view these articles visit https://doi.org/10.1111/apt.14186 and https://doi.org/10.1111/apt.14200.
Letter: sprue‐like enteropathy associated with angiotensin II receptor blockers other than olmesartan—authors'reply
Authors: Marthey L. , Carbonnel F. 
Published: July 2017

Linked ContentThis article is linked to Zanelli and Negro et al and Marthey and Carbonnel papers. To view these articles visit https://doi.org/10.1111/apt.14176 and https://doi.org/10.1111/apt.14191.
Editorial: liver transplantation in patients with non‐alcoholic fatty liver disease and obesity—authors’ reply
Authors: Barone M. , Viggiani M. T. , Losurdo G. , Principi M. , Leandro G. , Di Leo A. 
Published: July 2017

Linked ContentThis article is linked to Townsend and Newsome et al and Barone et al papers. To view these articles visit https://doi.org/10.1111/apt.14179 and https://doi.org/10.1111/apt.14195.
Systematic review with meta‐analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection
Authors: Quraishi M. N. , Widlak M. , Bhala N. , Moore D. , Price M. , Sharma N. , Iqbal T. H. 
Published: July 2017

SummaryBackgroundClostridium difficile infection (CDI) is the commonest nosocomial cause of diarrhoea. Faecal microbiota transplantation (FMT) is an approved treatment for recurrent or refractory CDI but there is uncertainty about its use.AimTo evaluate the efficacy of FMT in treating recurrent and refractory CDI and investigate outcomes from modes of delivery and preparation.MethodsA systematic review and meta‐analysis was performed. MEDLINE, EMBASE, CINAHL, Cochrane Library, trial registers and conference proceedings were searched. Studies on FMT in recurrent and refractory CDI were included. The primary outcome was clinical resolution with subgroup analyses of modes of delivery and preparation. Random effects meta‐analyses were used to combine data.ResultsThirty seven studies were included; seven randomised controlled trials and 30 case series. FMT was more effective than vancomycin (RR: 0.23 95%CI 0.07‐0.80) in resolving recurrent and refractory CDI. Clinical resolution across all studies was 92% (95%CI 89%‐94%). A significant difference was observed between lower GI and upper GI delivery of FMT 95% (95%CI 92%‐97%) vs 88% (95%CI 82%‐94%) respectively (P=.02). There was no difference between fresh and frozen FMT 92% (95%CI 89%‐95%) vs 93% (95%CI 87%‐97%) respectively (P=.84). Administering consecutive courses of FMT following failure of first FMT resulted in an incremental effect. Donor screening was consistent but variability existed in recipient preparation and volume of FMT. Serious adverse events were uncommon.ConclusionFaecal microbiota transplantation is an effective treatment for recurrent and refractory Clostridium difficile infection, independent of preparation and route of delivery.
Editorial: different tests for different drugs in Crohn’s disease, or different tests for different people? Authors’ reply
Authors: Ward M. G. , Irving P. M. 
Published: July 2017

Linked ContentThis article is linked to Seow and Panacionne and Ward and Irving papers. To view these articles visit https://doi.org/10.1111/apt.14185 and https://doi.org/10.1111/apt.14209.
Crossing boundaries of state and religious power: Reproductive mobilities in Singapore
Authors: Mariano Danicar , Yeoh Brenda S.A. , Cheng Yi'En 
Published: July 2017

AbstractSingapore has one of the tightest regulations over assisted reproductive technologies (ARTs) in Asia, a consequence of Singapore's strong state, the priority it gives to reproduction, and the numerous religious groups in the country and their direct and indirect influence on the Bioethics Advisory Committee, which recommends ART regulations for the country. Together, these key actors give shape to the ‘local moral worlds’, which undergird ART governance in the country. Drawing on in‐depth interviews and data from online forums, we illustrate Singaporean fertility seekers' attempts to juggle myriad and sometimes confusing obligations to the state, society and religion in making reproductive choices. We then explore the limits and possibilities for fertility seekers to circumvent the restrictive rules and ‘moral safety valves’ set in place in their home country simply by stepping out to another jurisdiction across national borders. The paper goes on to show how the Internet communities serve as a bridgespace, propelling fertility mobilities by enabling Singaporeans to see creative possibilities in patchwork regulations. At the edges of state and religious power, fertility‐seeking subjects take advantage of liminal spaces, grey areas, or permissive regimes to gain several degrees of freedom to practise adaptive fertility strategies that may be ‘unofficial’ but ‘licit’ or ‘socially acceptable’.
Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1
Authors: Edlinger Leo , Berger‐Becvar Angelika , Menzl Ingeborg , Hoermann Gregor , Greiner Georg , Grundschober Eva , Bago‐Horvath Zsuzsanna , Al‐Zoughbi Wael , Hoefler Gerald , Brostjan Christine , Gille Lars , Moriggl Richard , Spittler Andreas , Sexl Veronika , Hoelbl‐Kovacic Andrea 
Published: July 2017

SummaryThe p21‐activated kinases (PAKs) are key nodes in oncogenic signalling pathways controlling growth, survival, and motility of cancer cells. Their activity is increased in many human cancers and is associated with poor prognosis. To date, PAK deregulation has mainly been studied in solid tumours, where PAK1 and PAK4 are the main isoforms deregulated. We show that PAK1 and PAK2 are the critical isoforms in a BCR/ABL1+ haematopoietic malignancy. In suspension, leukaemic cells deficient for PAK1 and PAK2 undergo apoptosis, while the loss of either protein is well tolerated. Transfer of medium conditioned by shPAK2‐ but not shPAK1‐expressing leukaemic cells interferes with endothelial cell growth. We found that leukaemic cells produce exosomes containing PAK2. Transfer of isolated exosomes supports endothelial cell proliferation. In parallel, we found that leukaemic cells explicitly require PAK2 to grow towards an extracellular matrix. PAK2‐deficient cells fail to form colonies in methylcellulose and to induce lymphomas in vivo. PAK2 might therefore be the critical isoform in leukaemic cells by controlling tumour growth in a dual manner: vascularization via exosome‐mediated transfer to endothelial cells and remodelling of the extracellular matrix. This finding suggests that the PAK2 isoform represents a promising target for the treatment of haematological diseases.
Melatonin receptors: molecular pharmacology and signalling in the context of system bias
Authors: Cecon Erika , Oishi Atsuro , Jockers Ralf 
Published: July 2017

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are members of the GPCR family. Among the multiple effects attributed to melatonin, we will focus here on those that are dependent on the activation of the two mammalian MT1 and MT2 melatonin receptors. We briefly summarize the latest developments on synthetic melatonin receptor ligands, including multi‐target‐directed ligands, and the characterization of signalling‐biased ligands. We discuss signalling pathways activated by melatonin receptors that appear to be highly cell‐ and tissue‐dependent, emphasizing the impact of system bias on the functional outcome. Different proteins have been demonstrated to interact with melatonin receptors, and thus, we postulate that part of this system bias has its molecular basis in differences of the expression of receptor‐associated proteins including heterodimerization partners. Finally, bias at the level of the receptor, by the expression of genetic receptor variants, will be discussed to show how a modified receptor function can have an effect on the risk for common diseases like type 2 diabetes in humans.Linked ArticlesThis article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc
Arterial immune protein expression demonstrates the complexity of immune responses in Kawasaki disease arteritis
Authors: Cameron S A , White S M , Arrollo D , Shulman S T , Rowley A H 
Published: July 2017

SummaryA more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and in this study sought to determine protein expression of transcriptionally up-regulated immune genes in KD coronary arteries from the first 2 months after disease onset. We examined the coronary arteries of 12 fatal KD cases and 13 childhood controls for expression of a set of proteins whose genes were highly up-regulated in the KD coronary artery transcriptome: allograft inflammatory factor 1 (AIF1), interleukin 18 (IL-18), CD74, CD1c, CD20 (MS4A1), Toll-like receptor 7 (TLR-7) and Z-DNA binding protein 1 (ZBP1). Immunohistochemistry and immunofluorescence studies were performed to evaluate protein expression and co-localization, respectively. AIF1 was expressed transmurally in KD arteritis and localized to macrophages and myeloid dendritic cells. CD74, which interacts with major histocompatibility complex (MHC) class II on antigen-presenting cells, localized to the intima-media. CD1c, a marker of myeloid dendritic cells, was expressed in a transmural pattern, as were IL-18 and CD20. ZBP1 and TLR-7 were up-regulated compared to controls, but less highly compared to the other proteins. These findings provide evidence of antigen presentation and interferon response in KD arteritis. In combination with prior studies demonstrating T lymphocyte activation, these results demonstrate the complexity of the KD arterial immune response.
Complement and contact system activation in acute congestive heart failure patients
Authors: Suffritti C , Tobaldini E , Schiavon R , Strada S , Maggioni L , Mehta S , Sandrone G , Toschi-Dias E , Cicardi M , Montano N 
Published: July 2017

Summary
Recent experimental data indicate a pathogenic role of complement activation in congestive heart failure (CHF). The aim of this study was to evaluate contact and complement systems activation in patients hospitalized for an acute episode of CHF. Forty-two of 80 consecutive patients admitted at our hospital with confirmed diagnosis of acute CHF were enrolled. They underwent blood sampling within 24 h from admission (T0) and at clinical stability (T1). Patients were stratified for ejection fraction (EF) based on echocardiographic test. We measured plasma levels of C3, C4, sC5b-9 and cleaved high molecular weight kininogen (contact activation marker). At T1, C3 levels increased significantly compared to T0 (97 ± 2 versus 104 ± 3% of total pooled plasma, P &lt; 0·01). Classifying patients according to EF, only patients with preserved EF presented a significant increase of C3 from T0 to T1 (99 ± 3 versus 108 ± 4%, P = 0·03). When the sample was stratified according to clinical outcome, C3 (98 ± 3 versus 104 ± 4%, P = 0·03) and sC5b-9 levels (204 ± 10 versus 230 ± 11 ng/ml, P = 0·03) were increased in patients who had positive outcome after hospitalization. CHF patients with preserved EF and positive outcome after hospitalization showed higher levels of sC5b-9 in the T1 period compared with T0 (211 ± 14 versus 243 ± 14 ng/ml, P = 0·04). Our results suggest that the complement system reacts differently if CHF occurs with preserved or reduced EF. This finding is interesting if we consider the difference in epidemiology, pathogenesis and possible therapeutic approaches of these two clinical entities.
A new equation to predict peak VO2 in obese patients during cardiopulmonary exercise testing
Authors: Barbosa Alan Carlos Brisola , Sperandio Evandro Fornias , Gonze Bárbara de Barros , Spina Giovanna Domingues , Arantes Rodolfo Leite , Gagliardi Antônio Ricardo de Toledo , Romiti Marcello , Dourado Victor Zuniga 
Published: July 2017

SummaryWe aimed to develop an equation to predict peak VO2 in obese subjects undergoing CPET. In addition, we evaluated and compared three published equations. We randomized 346 obese subjects undergoing CPET into a group for developing the equation (n = 272) and a group for cross‐validation (n = 74), compared through the Bland and Altman method. Height, sex and age were responsible for 85·5% of total variability of the peak VO2. Additional 1% and 0·7% of the variability were, respectively, explained by physical inactivity and diabetes. The equation devised was as follows: The mean difference between the estimated and measured peak VO2 was 7 ml min−1, with a 23·9% bias. Published equations overestimated the peak VO2 by 35·3%, 49·1% and 46·2% bias. The equation developed in this study performed better in predicting peak VO2 in obese adults improving ramp protocol design and CRF evaluations in obese subjects.
Wholesale Price Auctions for Dual Sourcing under Supply Risk
Authors: Huang He , Li Zhipeng , Xu Hongyan 
Published: July 2017

ABSTRACTWholesale price bids commonly occur in procurement auctions where dual sourcing is usually employed to mitigate supply risks. When at most two winners are required, unreliable wholesale price bidders face the unique trade‐off between unit margin and quantity allocation that depends on both winners' bids and the reliabilities. Motivated by above facts and considerations, we investigate several auction formats accommodating wholesale price bids for dual sourcing under newsvendor market, with unreliable suppliers possessing private costs. Generalized first‐price auction (GFA) is designed under known cost distribution, while generalized English auction (GEA) and optimal auction with learning (OAL) are examined under unknown distribution. Through a preannounced allocation rule to curb the bidding behavior, both GFA and OAL balance information rent and quantity allocation and generate various diversification degrees. Information asymmetry under GFA depresses the quantity proportion for high‐cost winner, because he charges higher unit information rent than low‐cost winner does. In contrast, two winners in GEA collude at the same price and thus split the order quantity evenly. The full diversification possibly enables GEA to generate higher service level than GFA under high supply risk, although the expected output quantity of GEA is always lower. Regarding the practical requirement for auction format choice, when the costs of implementation and distribution acquisition are not negligible, the previous analysis suggests that the favorable format is driven from GFA or OAL to GEA, as supply risk or the number of bidders increases, or as retail price exceeds a threshold. We also extend to multisourcing cases and examine the impacts of salvage and lost sale on auction format choice.
An intelligent system to monitor refrigeration devices
Authors: Kužnar Damjan , Piltaver Rok , Gradišek Anton , Gams Matjaž , Luštrek Mitja 
Published: July 2017

AbstractRefrigeration systems have been a vital component of our lives for more than a century. Apart from storing food, they are used to store sensitive goods such as pharmaceutical products or reactive chemicals. The deterioration of the refrigeration system performance due to aging or malfunction directly affects the quality of stored goods. Therefore, an early detection of deviation in performance is an important task. This paper presents a system that monitors operation of refrigeration devices and alerts the user to possible irregularities in the operation run. The emphasis is on recognition of gradual changes of performance that indicate upcoming hardware problems. The system consists of 2 modules: human‐defined expert rules and machine learning. The machine‐learning module learns to recognize abnormal behaviour of devices automatically. Furthermore, it can distinguish between different abnormal events and allow the user to classify some of the types as normal, so that they not longer raise an alarm. The machine learning was evaluated by comparing its recognition of abnormal events and classification accuracy of such events to the performance of a human operator. The system can in principle be adapted to any electronic device that periodically applies some system for sustaining a predefined quality (e.g., temperature).