bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective case–control study on pain intensity after the use of promethazine in patients undergoing videothoracoscopy
Authors: Zhou Xiangwei , He Benhui , Zheng Xia , Li Chao , Mi Zeyu , Peng Mingqing , Li Min 
Published: September 2024

ObjectiveEffective and secure pain management following video-assisted thoracoscopic surgery (VATS) is crucial for rapid postoperative recovery. This study evaluated analgesic and sedative effects of sufentanil and promethazine in patient-controlled intravenous analgesia (PCIA) post-thoracic surgery, along with potential adverse reactions.MethodsIn this prospective, randomized, controlled, double-blind, clinical study, 60 patients (American Society of Anesthesiologists status I–III) undergoing VATS were enrolled. The patients were randomized into experimental (Group P) or control (Group C) groups. PCIA was administered post-general anesthesia using a double-blind method. Group P received sufentanil (3 μg/kg) + promethazine (1 mg/kg) + 0.9% sodium chloride solution (100 mL total), while Group C received sufentanil (3 μg/kg) + 0.9% sodium chloride solution (100 mL total). PCIA settings included a 1-mL bolus and 15-min locking time. The primary outcomes were the visual analog scale (VAS) at rest and during coughing and sedation (Ramsay) scores at 6, 12, 24, and 48 h. The secondary outcomes were rescue drug use rate, hemodynamic parameters (mean arterial pressure and heart rate), percutaneous oxygen saturation, respiratory rate, and occurrence of adverse reactions.ResultsGroup P exhibited lower resting and coughing VAS scores at 6, 12, 24, and 48 h, plus decreased incidence of nausea and vomiting within 48 h post-surgery compared with Group C (p &lt; 0.05). No significant differences were observed in pruritus, sedation (Ramsay) scores, mean arterial pressure, heart rate, oxygen saturation, or respiratory rate between the two groups (p &gt; 0.05).DiscussionThe combination of sufentanil and promethazine for postoperative intravenous analgesia could effectively reduce adverse effects such as nausea and vomiting, contributing to postoperative pain relief.
Epidemiological survey of calf diarrhea related viruses in several areas of Guangdong Province
Authors: Chen Jinping , Meng Wenxin , Zeng Huijuan , Wang Jingyu , Liu Shizhe , Jiang Qifeng , Chen Zihan , Ma Zihang , Wang Zhen , Li Shoujun , Jia Kun 
Published: September 2024

IntroductionBovine torovirus (BToV), Bovine enterovirus (BEV), Bovine norovirus (BNoV), Bovine coronavirus (BCoV), Bovine rotavirus (BRV), and Bovine viral diarrhea virus (BVDV) are significant pathogens causing diarrhea in calves, characterized by their high prevalence and challenging prevention and control measures.MethodsWe analyzed 295 calf diarrhea samples, amplifying the M gene from BToV-positive samples, the 5’UTR gene from BEV-positive samples, the RdRp gene from BNoV-positive samples, the VP7 gene from BRV-positive samples, the S gene from BCoV-positive samples, and the 5’UTR gene from BVDV-positive samples. Subsequent homology analysis and phylogenetic tree construction were performed.ResultsThe overall viral positive rate in Guangdong Province was 21.36%. Specific detection rates were as follows: Foshan City at 50.00% (18/36), Guangzhou City at 43.90% (36/82), Huizhou City at 21.21% (7/33), Yangjiang City at 2.08% (1/48), Meizhou City at 1.39% (1/72), and Heyuan City at 0.00% (0/24). The detection rates for BToV, BEV, BNoV, BCoV, BRV, and BVDV were 0.34% (1/295), 6.10% (18/295), 0.68% (2/295), 1.36% (4/295), 10.85% (32/295), and 2.03% (6/295), respectively. Notably, the highest overall virus detection rate was observed in the Guangzhou-Foshan region, with BRV and BEV showing the highest detection rates among the six viruses. This study marks the first report of BToV and BNoV in Guangdong Province. Phylogenetic analysis revealed that the BToV strain belonged to type II, sharing genetic similarities with epidemic strains from various provinces in China. The BEV strains were categorized into E and F types, with the F type being the predominant strain in Guangdong Province and exhibiting the closest genetic relationship to strains from Heilongjiang and Guangxi. The BNoV strains, along with Hebei strains, were identified as GIII.2 subgenotype. BCoV strains showed the highest genetic similarity to strains from Sichuan. All BRV strains were classified under the G6 subtype and had the closest genetic relationship with human rotavirus strains. BVDV strains were identified as subtype 1b, closely related to the Beijing strain. In conclusion, this study investigated the prevalence and evolutionary characteristics of diarrhea-associated viruses in calves in specific areas of Guangdong Province, providing a valuable reference for establishing effective prevention and control measures in cattle farms.
Correspondence between white matter hyperintensities and regional grey matter volumes in Alzheimer's disease
Authors: Yi Fangyuan , Wang Jirui , Lin Meiqing , Li Baizhu , Han Shiyu , Wang Shan , Jin Yingbin , Hu Ning , Chen Yutong , Shang Xiuli 
Published: September 2024

ObjectiveWhite matter hyperintensities (WMH) are the most common neuroimaging manifestation of cerebral small vessel disease, and is frequently observed in Alzheimer’s disease (AD). This study aimed to investigate the relationship between WMH and cognition and to verify the mediation of grey matter atrophy in this relationship.MethodsThe diffusion tensor imaging (DTI) technique analyses white matter fiber tract to assess white matter integrity. Voxel-based morphometry was applied to measure the grey matter volume (GMV). A linear regression model was applied to examine the associations between WMH and GMV, and mediation analyses was performed to determine the mediating role of regional GMV in the effect of WMH on cognitive function.ResultsCompared to the HC group, AD group have 8 fiber tract fractional anisotropy (FA) decreased and 16 fiber tract mean diffusivity (MD) increased. Compared to AD without WMH, AD with high WMH had 9 fiber tracts FA decreased and 13 fiber tracts MD increased. High WMH volume was negatively correlated with GMV in the frontal–parietal region. Low WMH volume was also negatively correlated with GMV except for the three regions (right angular gyrus, right superior frontal gyrus and right middle/inferior parietal gyrus), where GMV was positively correlated. Mediation analysis showed that the association between WMH and executive function or episodic memory were mediated by GMV in the frontal–parietal region.ConclusionDamage to white matter integrity was more severe in AD with WMH. Differential changes in DTI metrics may be caused by progressive myelin and axonal damage. There was a negative correlation between WMH and grey matter atrophy in frontal–parietal regions in a volume-dependent manner. This study indicates the correspondence between WMH volume and GMV in cognition, and GMV being a key modulator between WMH and cognition in AD. This result will contribute to understanding the progression of the disease process and applying targeted therapeutic intervention in the earlier stage to delay neurodegenerative changes in frontal–parietal regions to achieve better treatment outcomes and affordability.
Intelligent analysis and measurement of semicircular canal spatial attitude
Authors: Zhou Mi , Mao Jiesheng , Li Xiaoqing , Li Yanjun , Yang Xiaokai 
Published: September 2024

ObjectiveThe primary aim of this investigation was to devise an intelligent approach for interpreting and measuring the spatial orientation of semicircular canals based on cranial MRI. The ultimate objective is to employ this intelligent method to construct a precise mathematical model that accurately represents the spatial orientation of the semicircular canals.MethodsUsing a dataset of 115 cranial MRI scans, this study employed the nnDetection deep learning algorithm to perform automated segmentation of the semicircular canals and the eyeballs (left and right). The center points of each semicircular canal were organized into an ordered structure using point characteristic analysis. Subsequently, a point-by-point plane fit was performed along these centerlines, and the normal vector of the semicircular canals was computed using the singular value decomposition method and calibrated to a standard spatial coordinate system whose transverse planes were the top of the common crus and the bottom of the eyeballs.ResultsThe nnDetection target recognition segmentation algorithm achieved Dice values of 0.9585 and 0.9663. The direction angles of the unit normal vectors for the left anterior, lateral, and posterior semicircular canal planes were [80.19°, 124.32°, 36.08°], [169.88°, 100.04°, 91.32°], and [79.33°, 130.63°, 137.4°], respectively. For the right side, the angles were [79.03°, 125.41°, 142.42°], [171.45°, 98.53°, 89.43°], and [80.12°, 132.42°, 44.11°], respectively.ConclusionThis study successfully achieved real-time automated understanding and measurement of the spatial orientation of semicircular canals, providing a solid foundation for personalized diagnosis and treatment optimization of vestibular diseases. It also establishes essential tools and a theoretical basis for future research into vestibular function and related diseases.
Opioid Use Disorder and intracerebral hemorrhage in Isfahan, Iran: a case–control study
Authors: Saadatnia Mohammad , Norouzi Razieh , Najafi Mohammad Amin , Gol Parvar Sahand , Najafian Arash , Tabatabei Aryan , Foroughi Melika , Esteki Sadaf , Khorvash Fariborz 
Published: September 2024

BackgroundOpium use disorder is a significant health problem in our country, leading to a considerable number of health issues. Opium has several detrimental effects on its consumers. However, the effect of Opium use disorder on intracerebral hemorrhage (ICH) has not been evaluated. This study aims to evaluate the relationship between Opium use disorder and ICH.MethodsIn this case–control study, 402 patients with ICH and 404 patients without ICH enrolled. Opium use disorder, other vascular risk factors including diabetes mellitus, hypertension, hyperlipidemia, and tobacco smoking was compared between these groups. Patients with ICH were divided into two groups; first group are patients with history of Opioid Use Disorder and second group are those patients without Opioid Use Disorder. ICH features including clinical and imaging characteristics and prognostic findings were compared between patients with and without Opium use disorder.ResultsThis case–control study of 806 participants found that hypertension (OR = 6.84, 95% CI: 5.03–9.34, p-value: &lt;0.001), Opium use disorder (OR = 4.23, 95% CI: 2.42–7.35, p-value: &lt;0.001) and tobacco smoking (OR = 1.47, 95% CI: 1.01–2.16, p-value: 0.049) had a higher risk of ICH. Opium-addicted subjects had higher ICH scores (2.61 ± 1.27 vs. 2.11 ± 1.29, p-value: 0.005), were more likely to have infratentorial hemorrhage (22% vs. 12%, OR = 2.13, 95% CI: 1.06–4.28, p-value: 0.038), more likely to be intubated (66% vs. 54%, OR = 1.79, 95% CI: 0.98–3.27, p-value = 0.041) and had lower GCS scores (9.58 ± 3.60 vs. 8.25 ± 3.88, p-value: 0.01). The effect of Opium use disorder independently on ICH was also shown in logistic regression (adjusted OR = 3.15, p-value = 0.001).ConclusionThis study is the first to evaluate the effect of Opium use disorder on ICH, identifying Opium use disorder as a new potential risk factor for ICH.
Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function
Authors: Osuna-Padilla Iván Armando , Rodríguez-Moguel Nadia Carolina , Aguilar-Vargas Adriana , Tolentino-Dolores Maricruz , Perichart-Perera Otilia , Ahumada-Topete Victor , Ávila-Ríos Santiago , Soto-Nava Maribel , Diaz-Rivera Dafné , De León-Lara Enrique , Wilson-Verdugo Marti , Briceño Olivia 
Published: September 2024

Background and aimDeficiency of zinc and selenium is common in persons living with human immunodeficiency virus (PLWHIV) and has been associated with the development of non-AIDS related comorbidities, impaired immune system function and mortality. Micronutrient supplementation on long-term-treated PLWHIV could bring potential clinical and immunological benefits improving their health status and quality of life. The aim of the present study is to analyze the effect of zinc and selenium supplementation on body composition, bone mineral density, CD4+ T-cell counts, metabolic profile and immune system status on clinical stable PLWHIV on long-term antiretroviral therapy (ART).MethodsThis is a randomized pilot clinical trial in which we recruited 60 PLWHIV on ART who were assigned to the intervention groups: zinc (30 mg of zinc gluconate), selenium (200 μg of selenium yeast), zinc + selenium (same doses and presentations) or to a control group (without nutritional supplementation) who received supplementation during 6 months. Primary outcome was defined as changes in body composition (weight, muscle and fat mass and bone mineral density) and secondary outcomes as changes in biochemical and immunological parameters (CD4+ T-cell count, cholesterol, glucose, triglycerides and seric zinc and selenium seric concentrations) before and after supplementation. Peripheral blood mononuclear cells (PBMCs) of one individual of each intervention group were analyzed for single cell transcriptomics before and after supplementation.ResultsBMI (p = 0.03), fat mass (p = 0.03), and trunk fat (p = 0.01) decreased after 6 months of selenium supplementation. No changes were observed for cholesterol, glucose or triglycerides after supplementation (p &gt; 0.05 in all cases). CD4+ T cells percentage increased after 6 months of selenium supplementation (p = 0.03). On the transcriptome analysis, zinc and selenium supplementation induced changes on de expression of genes associated with the function of naive and memory CD8+ T-cells (p &lt; 0.05 in all cases).ConclusionZinc and selenium supplementation could represent a complementary intervention that may improve the health status and immune response of treated PLWHIV.
Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation
Authors: Hui Caressa , Simiele Eric , Lozko Yuliia , Romero Ignacio , Skinner Lawrie , Binkley Michael Sargent , Hoppe Richard , Kovalchuk Nataliya , Hiniker Susan M. 
Published: September 2024

IntroductionVolumetric modulated arc therapy (VMAT) total body irradiation (TBI) allows for greater organ sparing with improved target coverage compared to 2D-TBI. However, there is limited evidence of whether improved organ sparing translates to decreases in toxicities and how its toxicities compare to those of the 2D technique. We aimed to compare differences in toxicities among patients treated with TBI utilizing VMAT and 2D techniques.Methods/materialsA matched-pair single-institution retrospective analysis of 200 patients treated with TBI from 2014 to 2023 was performed. Overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan–Meier method and compared using log-rank tests. Differences in characteristics and toxicities between the VMAT and 2D cohorts were compared using Fisher’s exact test.ResultsOf the 200 patients analyzed, 100 underwent VMAT-TBI, and 100 underwent 2D-TBI. The median age for VMAT-TBI and 2D-TBI patients was 13.7 years and 16.2 years, respectively (p = 0.25). In each cohort, 53 patients were treated with myeloablative regimens (8–13.76 Gy), and 47 were treated with non-myeloablative regimens (2–4 Gy). For the entire VMAT-TBI cohort, lung Dmean, kidney Dmean, and lens Dmax were spared to 60.6% ± 5.0%, 71.0% ± 8.5%, and 90.1% ± 3.5% of prescription, respectively. For the non-myeloablative VMAT-TBI cohort, testis/ovary Dmax, brain, and thyroid Dmean were spared to 33.4% ± 7.3%, 75.4% ± 7.0%, and 76.1% ± 10.5%, respectively. For 2D-TBI, lungs were spared using partial-transmission lung blocks for myeloablative regimens. The VMAT-TBI cohort experienced significantly lower rates of any grade of pneumonitis (2% vs. 12%), nephrotoxicity (7% vs. 34%), nausea (68% vs. 81%), skin (16% vs. 35%), and graft versus host disease (GVHD) (42% vs. 62%) compared to 2D-TBI patients. For myeloablative regimen patients, rates of pneumonitis (0% vs. 17%) and nephrotoxicity (9% vs. 36%) were significantly lower with VMAT-TBI versus 2D-TBI (p &lt; 0.01). Median follow-up was 14.3 months, and neither median OS nor PFS for the entire cohort was reached. In the VMAT versus 2D-TBI cohort, the 1-year OS was 86.0% versus 83.0% (p = 0.26), and the 1-year PFS was 86.6% and 80.0% (p = 0.36), respectively.ConclusionNormal tissue sparing with VMAT-TBI compared to the 2D-TBI translated to significantly lower rates of pneumonitis, renal toxicity, nausea, skin toxicity, and GVHD in patients, while maintaining excellent disease control.
Global trends of Pauwels type III femoral neck fractures: bibliometric analysis and visualized study
Authors: Wang Mengyu , Zhang Ze , Sun Fengpo , Zhu Yi , Han Ruining , Pei Zijie , He Zhaoshuo , Liu Junzhi , Wen Liangyuan 
Published: September 2024

BackgroundPauwels type III femoral neck fractures, as a serious type of femoral neck fractures, have brought about a heavy economic burden on families and society for the high disability rate. Through bibliometric research and visualized analysis, this study aimed at elucidating the global research status of Pauwels type III femoral neck fractures to date, and predicting the future research trends in this field.MethodsPublications and associated information on Pauwels type III femoral neck fractures to date were retrieved from Web of Science Core Collection, and by VoSviewer and R package “bibliometrix”, bibliometric analysis and visual presentation was conducted.ResultsBy retrieval, a total of 98 studies were refinedly extracted, and the volume of publications in this field increased year-over-year. China ranked first in terms of total publication volume and H-Index, with its total citation records second only to the United States. The country with the highest average citation frequency was Switzerland. SHANGHAI JIAO TONG UNIVERSITY was the most productive research institution. Among the authors in this field, Li, Jiantao had published the most researches. INJURY INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED and JOURNAL OF ORTHOPAEDIC TRAUMA were the two magazines with the highest publication volume, total citation records, and H-index. According to keywords co-occurrence analysis, the research content in the past 24 years is mainly divided into four different dimensions. Finite element analysis, femoral neck system, medial buttress plate, cannulated screws, hip screw, open reduction, complications are hot topics for future research.ConclusionsAccording to the global trends analysis of publications production, Pauwels type III femoral neck fractures are receiving increasing attention and input from scholars. China has made the greatest scientific research contribution among countries, but its academic quality should be improved further. The modified therapeutic methods designed for addressing the complications of traditional internal fixation for Pauwels III femoral neck fractures will be the future research hotspot.
مصفوفة الاحتمالات والتحول المعاصر في ترميم الخزف
Authors: بنت صالح الصالح منال 
Published: September 2024

تهدف هذه الدراسة الى ايجاد حلول معاصرة لترميم القطع الخزفية من خلال الاستعانة بمصفوفة الاحتمالات والتي تحمل جوانب فلسفية تتعدى مسألة الحفاظ على الأثر الخزفي وعلاجه وصيانته، باستخدام تقنيات الترميم لإخفاء الضرر الذي وقع على العمل الخزفي وتحويل هذا الضرر إلى قيمة جمالية مضافة، متخذه المنھج الوصفي التحلیلي .
واهم ماتوصلت له الدراسة من النتائج أن ترميم الأشكال الخزفية الحديثة تختلف من حيث البعد الفلسفي والجمالي عن الترميم للشكل الخزفي الاثري ومن خلال الاحتماليات المطروحة في مصفوفة الترميم يمكن تقديم حلولاً تشكيلية وفنية تؤدي إلى ابتكار مجسمات خزفية معاصرة، وانتاج اشكال خزفية ذات بعد فلسفي وجمالي.وبنا ًء على نتائج الدراسة تم إدراج توصيات منها تطبيق احتمالية المصفوفة المقترحه من قبل الفنانين والمختصين بالآثار لاتساع دائرة الافق الفكري والفلسفي، كما أنه لابد من تزويد المكتبات والجهات المختصة لمدى اهمية النظر باحتمالية تحويل الفكر للاتجاه المعاصر بمعطياته المختلفة من خلال المصفوفة لايجاد حلول ابتكارية وحديثة في مجال الترميم، اما مجال الترميم فانه لابد من تنظيم دورات تدريبية في مجال الترميم ومدى امكانية الاستفادة من الدراسات البينية لاعادة الاشكال المرممة واظهارها بفكر معاصر.
Sosialisasi Peningkatan Kesadaran dan Keselamatan Berkendara di Kalangan Remaja SMA Negeri 2 Kelurahan Waru, Penajam Paser Utara
Authors: Matyani Matyani , Sofyan Orland Diadema Garibaldi , Wati Nurini Aprilia , Putri Vinny Cahya Wulan , Jhodelyn Khezya Cartila , Chayrunisa Nurmila , Nurhasan Wahyu , Nursella Nursella , Anindra Rhendy , Alfaridzi Muhammad Fatahila , Hadayati Nur 
Published: September 2024

Keselamatan berkendara merupakan isu yang mendesak di seluruh dunia, dengan kecelakaan lalu lintas terus menjadi ancaman bagi masyarakat. Faktor-faktor seperti peningkatan jumlah kendaraan, kurangnya kesadaran akan aturan lalu lintas, serta kurangnya infrastruktur yang aman telah menyebabkan tingginya angka kecelakaan dan korban jiwa. Studi ini menyelidiki berbagai aspek keselamatan berkendara, termasuk peran teknologi dalam mengurangi risiko kecelakaan, pendidikan tentang kesadaran lalu lintas, dan peran pemerintah dalam menyediakan infrastruktur yang aman. Tujuan dari pengabdian masyarakat ini yaitu untuk meningkatkan pengetahuan dan pentingnya kesadaran mengenai keselamatan berkendara pada pelajar SMA Negeri 2 Penajam Paser Utara. Metode pelaksanaan yang digunakan berupa pengajaran dan diskusi interaktif mengenai pentingnya keselamatan berkendara untuk para pelajar. Hasil dari pengabdian masyarakat yang dilakukan yaitu terwujudnya peningkatan kesadaran dan keselamatan berkendara pada remaja pelajar SMA Negeri 2 Penajam Paser Utara. Disarankan pemerintah dan pihak terkait untuk lebih sering memberikan sosialisasi dan edukasi kepada siswa/i maupun masyarakat terkait keselamatan berkendara. Bagi pengendara disarankan tetap berkendara dengan aman dan disiplin mematuhi peraturan lalu lintas.
Solar Atmospheric Oscillations as Measured by the GOES-R Series EXIS EUVS-C Instrument
Authors: Eden Thomas D. , Eparvier Francis. G. , Jones Andrew R. , McClintock William E. , Woodraska Donald L. , Woods Tom , Snow Martin 
Published: September 2024

Abstract
This Letter presents first observations of distinct solar atmospheric oscillations from signals collected by the Extreme Ultraviolet and X-ray Irradiance Sensors EUVS-C instrument, which is part of each Geostationary Observational Environmental Satellite R-Series instrument payload. The EUVS-C instrument is a full-disk, normal-incidence spectrograph that covers a narrow band in the mid-ultraviolet between 276 and 284 nm, where it can measure the magnesium ii emission doublet at ∼280 nm and the photospheric continuum. The primary goal of EUVS-C data is to construct the well-known Mg ii index, which is often used as a proxy for chromospheric activity. Because of the high temporal and spectral resolution of EUVS-C measurements, the data provide a unique opportunity to observe discernible solar atmospheric waves that have definite signatures of 3 and 5 minute oscillation periods, where the frequency response of these signals is dependent on what part of the spectrum is analyzed (e.g., Mg emission lines). Furthermore, both photospheric and chromospheric waves can simultaneously be examined. With the recent increase in solar activity for Solar Cycle 25, these waves exhibit enhanced amplitudes and phase shifts during the impulsive shock of strong solar flares. This Letter will discuss the analysis for deriving these waves, and results from both a quiescent Sun and an X-class solar flare event will be presented.