bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural activity during the viewing of emotional pictures in veterans with pathological anger and aggression
Authors: Heesink L. , Gladwin T.E. , Vink M. , van Honk J. , Kleber R. , Geuze E. 
Published: September 2017

AbstractAnger and aggression are common mental health problems after military deployment. Anger and aggression have been associated with abnormalities in subcortical and cortical levels of the brain and their connectivity. Here, we tested brain activation during the processing of emotional stimuli in military veterans with and without anger and aggression problems. Thirty military veterans with anger and aggression problems and 29 veterans without a psychiatric diagnosis (all males) participated in this study. During an fMRI scan 32 negative, 32 positive and 32 neutral pictures from the International Affective Picture System were presented in intermixed order. The Aggression group showed heightened activity in brain areas including the supplementary motor area, the cingulum and the parietal cortex, in response to stimuli, regardless of category. Furthermore, the Aggression group showed stronger connectivity between the dorsal anterior cingulate cortex (dACC) and the amygdala during the viewing of negative stimuli, and weaker connectivity between dACC and medial prefrontal cortex during the viewing of positive stimuli. Veterans with anger and aggression problems showed enhanced brain response to all stimuli during the task, irrespective of valence and they rated the pictures more likely as negative. We take this to indicate enhanced preparation for action and attention to the presentation of stimuli that could prove to be threatening. Further, group differences in functional connectivity involving the dACC reveal abnormal processing of stimuli with negative and positive valence. In sum, the results point towards a bias towards an enhanced sensitivity to perceived or potential threat in aggression.
Influence of the application of enemas with oily extract of curcumin (Curcuma longa) on the tissue content of neutral and acidic mucins in the colonic mucosa without fecal stream
Authors: Martinez Carlos Augusto Real , Oliveira Vitor Piquera de , Campos Fabio Guilherme , Kanno Danilo Toshio , Fernandez Oscar Orlando Araya , Kadri Caled Jaoudat , Pereira José Aires 
Published: September 2017

AbstractPurpose To verify if the application of enemas containing oily extracts of curcumin preserves the tissue content of mucins in the glands of the colonic mucosa without fecal stream.Method Thirty-six Wistar rats were submitted to diversion of the fecal stream by proximal colostomy and distal mucous fistula. The animals were subdivided into three groups, and accordingly received enemas with saline and oily extract of curcumin at concentrations of 50 mg/kg/day or 200 mg/kg/day. After two or four weeks of intervention, the irrigated colic segments were removed. Neutral and acidic mucins were identified by Periodic-acid Schiff and Alcian-Blue techniques, respectively. The content of both mucin subtypes was measured by computerized morphometry. Mann–Whitney test was used to analyze the results, adopting a significance level of 5% (p ≤ 0.05).Results There was an increase in the tissue content of neutral mucins in animals treated with curcumin at a concentration of 50 mg/kg/day for four weeks, whereas in the group treated with 200 mg/kg/day there was an increase independent of the time of intervention. The content of acidic mucins increased in animals treated with 200 mg/kg/day regardless of the intervention time, whereas in those treated with 50 mg/kg/day an increase was observed only after four weeks.Conclusion Enemas with curcumin preserve the content of neutral and acidic mucins in the colonic epithelium without fecal stream.
Improving Functional Mobility in Children and Adolescents Undergoing Treatment for Non–Central Nervous System Cancers: A Systematic Review
Authors: Wacker Katherine , Tanner Lynn , Ovans Jessica , Mason Jeffrey , Gilchrist Laura 
Published: September 2017

AbstractBackgroundChildhood cancers and subsequent treatments can leave survivors with impairments that may lead to decreased physical performance. Rehabilitation can be an important component of promoting improved physical function in children and adolescents undergoing treatment for cancer.ObjectiveTo review and synthesize evidence for nonsurgical, nonpharmacologic, rehabilitation interventions for children and adolescents undergoing treatment for non‐central nervous system cancers aimed at improving their physical impairments and functional mobility limitations.DesignA systematic review of the literature, from January 1996 to October 2016, on interventions for improving functional mobility and physical impairments in pediatric patients on treatment or recently off treatment for a non‐central nervous system cancer.SettingNot applicable.MethodsIncluded articles were reviewed for quality. Evidence for each impairment area was analyzed.Main Outcome MeasuresNot applicable.ResultsA total of 22 articles met our inclusion criteria. Only 7 randomized controlled trials were identified, and most studies had few subjects. More than one half of the existing clinical trials were on exercise or programs to increase strength and physical activity, with some evidence to support improvements in strength but mixed evidence for improving physical activity. Relatively few assessed other interventions used in rehabilitation such as orthotics, neuromuscular re‐education, and functional training.ConclusionThe body of literature describing nonsurgical and nonpharmacological interventions for decreased functional mobility and its related impairments is only beginning to emerge as few studies of high quality were found in the literature. Rehabilitation researchers and clinicians need to collaborate to produce the multi‐site trials that will be needed to best serve these children.
Geographical distribution and conservation status of an endemic insular mammal: the Vulnerable fish-eating batMyotis vivesi
Authors: Herrera M. L. Gerardo , Flores-Martínez José Juan , Sánchez-Cordero Víctor 
Published: September 2017

AbstractEndemic insular species are particularly vulnerable to anthropogenic threats. The fish-eating batMyotis vivesiis restricted mainly to the islands of the Gulf of California in Mexico and although several aspects of its biology have been studied there are no recent accounts of its current distribution. We conducted several expeditions during 2001–2016 to verify the current geographical distribution of this bat, and to record the presence of introduced predators. We identified the localities in which maternity colonies occur, estimated the size of the bat population on Partida Norte Island in 2003, and monitored bat presence on this island during 2004–2016. We found fish-eating bats on 36 islands and maternity colonies on 19 islands. Introduced ratsRattus rattusor catsFelis catuswere captured on seven islands where the bats were present, and on five islands where they were absent. We estimated a population of c. 30,000 fish-eating bats in May 2003 and we confirmed the species’ presence on Partida Norte Island during 2004–2016. Based on the information compiled from our surveys and previous studies, we discuss the adequacy of the species’ current categorization as Vulnerable on the IUCN Red List, and its conservation status conferred by Mexican conservation authorities.
COMPARISON OF METHODS FOR ESTIMATING CONTEMPORARY COSTS: AN APPLICATION TO LIVER TRANSPLANTATION IN THE UNITED KINGDOM
Authors: Singh Jeshika , Longworth Louise 
Published: September 2017

Objectives: Our study addresses the important issue of estimating treatment costs from historical data. It is a problem frequently faced by health technology assessment analysts. We compared four approaches used to estimate current costs when good quality contemporary data are not available using liver transplantation as an example.Methods: First, the total cost estimates extracted for patients from a cohort study, conducted in the 1990s, were inflated using a published inflation multiplier. Second, resource use estimates from the cohort study were extracted for hepatitis C patients and updated using current unit costs. Third, expert elicitation was carried out to identify changes in clinical practice over time and quantify current resource use. Fourth, routine data on resource use were obtained from National Health Service Blood and Transplant (NHSBT).Results: The first two methods did not account for changes in clinical practice. Also the first was not specific to hepatitis patients. The use of experts confirmed significant changes in clinical practice. However, the quantification of resource use using experts is challenging as clinical specialists may not have a complete overview of clinical pathway. The NHSBT data are the most accurate reflection of transplantation and posttransplantation phase; however, data were not available for the whole pathway of care. The best estimate of total cost, combining NHSBT data and expert elicitation, is £121,211.Discussion: Observational data from routine care are potentially the most reliable reflection of current resource use. Efforts should be made to make such data readily available and accessible to researchers. Expert elicitation provided reasonable estimates.
Effaced Enigmata
Authors: GILLETT GRANT 
Published: September 2017

Abstract:Severe head injury or brain injury presents clinical neuroscientists with a unique challenge. Based on an objective assessment of cognitive and neurological function, it is sometimes hard to recognize our patients as members of our moral community (actually or potentially) but we treat them as if that were is the case, and, therefore, as if they need rescuing. Thus their existences as enigmata—beings who may or may not reveal themselves to us through social and personal function realized in conversations and relationships—are in doubt. However, the objective mode of assessing individuals and their mental functions needs to be bracketed here, as we reconnect with them and offer them our help in the restorative journey that they need to take. The journey has many tortuous paths comprising it, not the least of which is the existential question of whether the damaged human being with whom we are engaged actually can be restored to a meaningful life. A negative answer to that question can bring the whole process to an abrupt end. Neuroscience cannot answer some of these questions, as they are ethical. Is this a life worth living and are our commitments going to go the distance that must be traversed here. Therefore, this is an area where ethics take priority over neuroscience, and it is on our ethical response that everything else hinges. Understanding the light this throws on the nature of a human being takes us to the heart of the value of every human being and the nexus of mutuality that is the moral community.
Practical Implications of the Minimally Conscious State Diagnosis in Adults
Authors: KREITMAIR KAROLA V. , KRUSE KATHERINE E. 
Published: September 2017

Abstract:This article addresses questions surrounding the minimally conscious state (MCS) from the perspective of adult clinical ethics. It describes the background of the MCS diagnosis, analyzes phenomenological ambiguities inherent in the nature of MCS, and raises epistemological concerns surrounding its diagnosis. It argues that in many cases, the burdens of prolonging treatment for people who have sustained certain severe brain injuries (SBI) outweigh the benefits, even if they are in or have the prospect of entering into MCS. It also argues that often such long-term measures are problematic from the perspective of patient preferences and stewardship of resources. Consequently, it suggests that the delineation of MCS as a distinct neurological state, along with research that seeks to expand how MCS is diagnosed, poses ethical difficulties for families and providers making decisions for affected patients.
MKP-1 negative regulates Staphylococcus aureus induced inflammatory responses in Raw264.7 cells: roles of PKA-MKP-1 pathway and enhanced by rolipram
Authors: Pan Yiqing , Xu Chen , Pan Zhixing K. 
Published: September 2017

AbstractMAP phosphatases (MKP)-1 acts as an important regulator of innate immune response through a mechanism of control and attention both MAPK and NF-κB molecules during bacterial infection. However, the regulatory role of MKP-1 in the interplay between MAPK and NFκB pathway molecules is still not fully understood. In present study, we showed a direct interactions of p38, ERK or IκBα with MKP-1, and demonstrated that MKP-1 was a pivotal feedback control for both MAP kinases and NF-κB pathway in response to S. aureus. In addition, we found that rolipram had anti-inflammatory activity and repressed IκBα activation induced by S. aureus via PKA-MKP-1 pathway. Our report also demonstrated that PKA-cα can directly bind to IκBα upon S. aureus stimulation, which influenced the downstream signaling of PKA pathway, including altered the expression of MKP-1. These results presented a novel mechanism of PKA and IκB pathway, which may be targeted for treating S. aureus infection.
Near room temperature chemical vapor deposition of graphene with diluted methane and molten gallium catalyst
Authors: Fujita Jun-ichi , Hiyama Takaki , Hirukawa Ayaka , Kondo Takahiro , Nakamura Junji , Ito Shin-ichi , Araki Ryosuke , Ito Yoshikazu , Takeguchi Masaki , Pai Woei Wu 
Published: September 2017

AbstractDirect growth of graphene integrated into electronic devices is highly desirable but difficult due to the nominal ~1000 °C chemical vapor deposition (CVD) temperature, which can seriously deteriorate the substrates. Here we report a great reduction of graphene CVD temperature, down to 50 °C on sapphire and 100 °C on polycarbonate, by using dilute methane as the source and molten gallium (Ga) as catalysts. The very low temperature graphene synthesis is made possible by carbon attachment to the island edges of pre-existing graphene nuclei islands, and causes no damages to the substrates. A key benefit of using molten Ga catalyst is the enhanced methane absorption in Ga at lower temperatures; this leads to a surprisingly low apparent reaction barrier of ~0.16 eV below 300 °C. The faster growth kinetics due to a low reaction barrier and a demonstrated low-temperature graphene nuclei transfer protocol can facilitate practical direct graphene synthesis on many kinds of substrates down to 50–100 °C. Our results represent a significant progress in reducing graphene synthesis temperature and understanding its mechanism.
Dual‐polarised X‐band patch sub‐array with hybrid feed network for integrated small‐satellite SAR payload
Authors: Zhao X. , Yeo S.P. , Ong L.C. 
Published: September 2017

A low‐profile wideband dual‐polarised X‐band patch sub‐array fed by a hybrid series/parallel network is designed for an integrated small‐satellite synthetic aperture radar payload. The experimental results demonstrate that the sub‐array, with 1 × 16 patch radiators, fully covers the targeted 9.65 GHz band with 14 dB bandwidths of 9–10.3 GHz for V‐polarisation (VP) and 9.3–9.95 GHz for H‐polarisation (HP). The isolation between the different feed ports is higher than 36 dB with a peak value of 45 dB. The sub‐array achieves cross‐to‐co‐polarisation ratios of below −32 dB within half‐power beamwidth scopes of 6° for both HP and VP. The sidelobes maintain −24 dB for HP and −20 dB for VP. The average realised gains are around 17 dBi for both polarisations.
Evaluation of Factors Affecting Outcome in Growth Hormone–Secreting Pituitary Adenomas
Authors: Padwal Amit , Gangadharan Jagath , Srinivas Dwarakanath , Somanna Sampath 
Published: September 2017

Introduction Management of functioning pituitary adenomas is challenging as they can present with features of an intracranial mass, systemic effects, or a combination of both. In this series, one of the largest in available literature from our country, we have analyzed our experience with surgical management of growth hormone (GH)-secreting pituitary adenomas and factors influencing their hormonal remission.
Materials and Methods The data of all functional pituitary adenomas operated at our institute from January 2002 to December 2011 were obtained from the case files of these patients. This was studied for various clinical-radiologic features, management stratagems, and clinical and hormonal outcomes.
Results Ninety-three patients of GH-secreting pituitary adenomas with a mean age of 32.7 years were included in the study. Fifty-three (57%) patients had headache at presentation; 46 (49%) had visual complaints, whereas menstrual irregularity was seen in majority of females. Mean GH level was 52.05 ng/mL. Fifty (53%) patients had invasive adenoma; 32 had cavernous sinus extension. Among 80 patients with hormonal follow-up, 43 (53.75%) achieved remission of GH level < 5 ng/mL.
Conclusion In this series, one of the largest of its kind, the main factors influencing unfavorable outcome include macroadenomas, invasiveness, high basal GH > 45 ng/mL levels, and mixed adenomas.
Postherpetic Anti-N-methyl-D-aspartate Receptor Encephalitis after Hemispherotomy in a Patient with Intractable Startle Epilepsy
Authors: Erkent Irem , Gocmen Rahsan , Oguz Kader , Kucuksahin Nalan , Soylemezoglu Figen , Bilginer Burcak , Saygi Serap , Tezer F. 
Published: September 2017

AbstractHerpes simplex encephalitis (HSE) has been increasingly reported after neurosurgical procedures, mostly after tumor resections in patients with a prior history of HSE. Early detection and appropriate treatment are essential to prevent high mortality of the disease; however, there are diagnostic difficulties due to nonspecific prodromal symptoms. In addition, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been reported after HSE as an immunological relapse. Here, we report a case of postherpetic anti-NMDAR encephalitis following right hemispherotomy for intractable startle-induced seizures, to emphasize the importance of early diagnosis and appropriate treatment. To our knowledge, this is the first reported case of anti-NMDAR encephalitis after postoperative HSE, and the third reported case of hemispherotomy as a curative treatment for startle epilepsy.
Angina pectoris bei einer jungen Frau mit Lupus erythematodes
Authors: Braumann Simon , Bartram Malte , Pfister Roman , Michels Guido 
Published: September 2017

Zusammenfassung
Anamnese und klinische Befunde Eine 31-jährige Patientin, die seit 6 Jahren an einem kutanen Lupus erythematodes (CLE) litt, präsentierte sich mit typischen pektanginösen Beschwerden. Das Ruhe-EKG und die transthorakale Notfall-Echokardiografie waren nicht wegweisend. Bei lediglich dezenter Troponin-Erhöhung ohne relevante Dynamik wurde die Arbeitsdiagnose einer Perikarditis gestellt und eine Therapie mit NSAR initiiert sowie die bisherige Immunsuppression intensiviert, worunter die Patientin beschwerdefrei entlassen werden konnte. Wenige Tage später erfolgte eine Wiedervorstellung in der rheumatologischen Klinik mit zunehmenden Beschwerden. In der Laborchemie fielen neben einer deutlichen Troponin-Erhöhung auch erhöhte Herzenzyme auf, sodass die Indikation zur Herzkatheteruntersuchung gestellt wurde. In der Koronarangiografie zeigte sich eine koronare 3-Gefäßerkrankung.
Therapie und Verlauf Die Patientin wurde einer dringenden operativen Myokardrevaskularisation zugeführt. Der postoperative Verlauf gestaltete sich trotz immunsuppressiver Therapie komplikationslos.
Folgerung Lupus-Patienten besitzen ein deutlich erhöhtes Risiko für eine koronare Herzerkrankung. Gerade bei jungen Frauen, die sich mit Brustschmerzen präsentieren, muss daher neben den klassischen kardiopulmonalen Lupusmanifestationen wie Pleuritis und Perikarditis differenzialdiagnostisch stets an ein akutes Koronarsyndrom gedacht werden.
Exploring experience and motivation using means-end chain theory.
Authors: Jiang Shan Jiang Shan 
Published: September 2017

Abstract

This chapter discusses the use of the means-end chain (MEC) approach as a method of capturing the motivational antecedents of tourists' experiences. MEC is a hierarchical ladder linking the attributes that exist in products (the means), to the consequences (benefits) for the consumer provided by the attributes, and ultimately to the personal values (the ends) the consequences reinforce. The chapter discusses the use of MEC for examining the reasons underlying the choice of tourist experiences.
Innovative approaches to researching consumer experience: an evaluation and comparison.
Authors: Wang Ying Wang Ying , Liu Wei Liu Wei , Sparks B. 
Published: September 2017

Abstract

This chapter seeks to broaden the approach to researching consumer experience in tourism through a discussion of multiple methods. The methods reviewed and evaluated include eye tracking, experience sampling method and photo elicitation. The chapter reviews each method, providing details on the advantages and disadvantages, and highlighting examples from the literature.
Perceived value of destination experiences in Zhouzhuang, China.
Authors: Gao LiHua Gao LiHua , Scott N. , Ding PeiYi Ding PeiYi 
Published: September 2017

Abstract

The study presented in this chapter identifies tourists' perceptions of value from their visit to Zhouzhuang, China. The study explores how the different types of value (functional, experiential, symbolic and cost values) that tourists perceived during their experience in the destination are related, and how those perceived customer values can help influence tourist behaviours or behavioural intentions.
Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice
Authors: Felix Angelina D R , Takahashi Nobuyuki , Takahashi Mami , Katsumata-Tsuboi Rie , Satoh Ryo , Soon Hui Teoh , Miyajima Katsuhiro , Nakae Dai , Inoue Hirofumi , Uehara Mariko 
Published: September 2017

Abstract
Rice powder extract (RPE) from black and brown rice (Oryza sativa L. indica) improves hepatic lipid accumulation in obese and diabetic model mice via peroxisomal fatty acid oxidation. RPE showed PPARα agonistic activity which did not differ between black and brown RPE despite a higher anthocyanin content in black RPE.
ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer’s disease
Authors: Tomljanovic Zeljko , Patel Mitesh , Shin William , Califano Andrea , Teich Andrew F 
Published: September 2017

Abstract

Motivation
In an effort to better understand the molecular drivers of synaptic and neurophysiologic dysfunction in Alzheimer’s disease (AD), we analyzed neuronal gene expression data from human AD brain tissue to identify master regulators of synaptic gene expression.

Results
Master regulator analysis identifies ZCCHC17 as normally supporting the expression of a network of synaptic genes, and predicts that ZCCHC17 dysfunction in AD leads to lower expression of these genes. We demonstrate that ZCCHC17 is normally expressed in neurons and is reduced early in the course of AD pathology. We show that ZCCHC17 loss in rat neurons leads to lower expression of the majority of the predicted synaptic targets and that ZCCHC17 drives the expression of a similar gene network in humans and rats. These findings support a conserved function for ZCCHC17 between species and identify ZCCHC17 loss as an important early driver of lower synaptic gene expression in AD.

Availability and implementation
Matlab and R scripts used in this paper are available at https://github.com/afteich/AD_ZCC

Supplementary information
Supplementary data are available at Bioinformatics online.