bluuebunny/crossref_metadata_2025_split huggingface dataset:
Random forest to differentiate dementia with Lewy bodies from Alzheimer's disease
Authors: Dauwan Meenakshi , van der Zande Jessica J. , van Dellen Edwin , Sommer Iris E.C. , Scheltens Philip , Lemstra Afina W. , Stam Cornelis J. 
Published: August 2016

AbstractIntroductionThe aim of this study was to build a random forest classifier to improve the diagnostic accuracy in differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) and to quantify the relevance of multimodal diagnostic measures, with a focus on electroencephalography (EEG).MethodsA total of 66 DLB, 66 AD patients, and 66 controls were selected from the Amsterdam Dementia Cohort. Quantitative EEG (qEEG) measures were combined with clinical, neuropsychological, visual EEG, neuroimaging, and cerebrospinal fluid data. Variable importance scores were calculated per diagnostic variable.ResultsFor discrimination between DLB and AD, the diagnostic accuracy of the classifier was 87%. Beta power was identified as the single‐most important discriminating variable. qEEG increased the accuracy of the other multimodal diagnostic data with almost 10%.DiscussionQuantitative EEG has a higher discriminating value than the combination of the other multimodal variables in the differentiation between DLB and AD.
Crucial role of pulmonary vein firing as an initiator of typical atrial flutter: Evidence of a close relationship between atrial fibrillation and typical atrial flutter
Authors: Kaneshiro Takashi , Yoshida Kentaro , Sekiguchi Yukio , Tada Hiroshi , Kuroki Kenji , Kuga Keisuke , Kamiyama Yoshiyuki , Suzuki Hitoshi , Takeishi Yasuchika , Aonuma Kazutaka 
Published: August 2016

AbstractBackgroundSeveral studies reported that cavotricuspid isthmus‐dependent atrial flutter (typical AFL) frequently coexists with atrial fibrillation (AF); however, the underlying mechanisms have not been fully investigated. This study aimed to reveal the mechanisms of the initiation of typical AFL and the association between typical AFL and AF.MethodsAmong 154 consecutive patients undergoing a first catheter ablation of AF, we investigated the appearance and mechanism of spontaneous initiation of typical AFL during catheter ablation. Then, we retrospectively investigated 67 consecutive patients without a previous AF episode who underwent typical AFL ablation. The occurrence and predictors of AF after catheter ablation were evaluated.ResultsDuring AF ablation, spontaneous initiation of typical AFL occurred during sinus rhythm in eight (5.2%) patients. The initiations of typical AFL were pulmonary vein (PV) firings except in one patient, in whom paroxysmal AF following superior vena cava firing initiated reverse typical AFL after PV isolation. After typical AFL ablation, AF occurred in 23 (34.3%) patients (mean follow up, 28.2±20.3 months). Kaplan‐Meier analysis showed the occurrence of AF after typical AFL ablation to be significantly higher in the patients with a larger left atrial diameter over 40 mm (log‐rank test, P=0.046).ConclusionsPV firing through AF played an important role in initiating typical AFL. The occurrence of AF after typical AFL ablation was high, and a dilated left atrium was associated with increased occurrence of AF. These findings disclosed the close relationship between typical AFL and AF, especially PV firing.
Multivariate Analysis of the Factors Associated with Sexual Intercourse, Marriage, and Paternity of Hypospadias Patients
Authors: Kanematsu Akihiro , Higuchi Yoshihide , Tanaka Shiro , Hashimoto Takahiko , Nojima Michio , Yamamoto Shingo 
Published: August 2016

ABSTRACT

Introduction
Patients with hypospadias are treated surgically during childhood, which has the intention of enabling a satisfactory sexual life in adulthood. However, it is unclear whether patients with corrected hypospadias can lead a satisfactory sexual life and sustain a marital relationship and produce offspring.

Aim
To evaluate factors associated with achievement of sexual intercourse, marriage, and paternity in patients with hypospadias who have reached adulthood.

Methods
Self-completion questionnaires were mailed in April 2012 to patients with hypospadias at least 18 years old who had been treated at our institution during childhood from 1973 through 1998 by a single surgeon and the same surgical policy. Assessments included the International Prostate Symptom Score, the International Index for Erectile Function-5, and non-validated questions related to current social and physical status and sexual, marital, and paternity experiences. Candidate factors were extracted from patients’ neonatal data, surgical findings and results, and current physical and social status obtained by the questionnaires.

Main Outcome Measures
Candidate factors associated with heterosexual intercourse, marriage, and paternity experiences were analyzed using univariate and multivariate proportional hazard models and log-rank test of Kaplan-Meier curves.

Results
Of the 518 patients contacted, 108 (age = 18–50 years, median = 28 years) met the inclusion criteria. Two- and one-stage repairs were performed as the initial treatment in 79 and 12, respectively, and 17 of the analyzed cases were reoperations for patients initially treated elsewhere. Fifty-seven patients had the milder type (31 glandular, 26 penile), 36 had the proximal type (13 penoscrotal, 23 scrotal-perineal), and 15 had an unknown type. Multivariate analyses by Cox proportional hazard model and log-rank tests confirmed that experience of sexual intercourse was associated with the milder type of hypospadias (P = .025 and .0076 respectively), marriage was associated with stable employment (P = .020 and .026, respectively), and paternity was associated with the absence of additional surgery after completion of the initial repair (P = .013 by multivariate analysis).

Conclusion
There was scant overlap of factors associated with the three events. The present findings provide reference information for surgeons and parents regarding future sexual and marriage experiences of children treated for hypospadias.
Transcript signatures that predict outcome and identify targetable pathways in MYCN‐amplified neuroblastoma
Authors: Hallett Robin M. , Seong Alex B.K. , Kaplan David R. , Irwin Meredith S. 
Published: August 2016

BackgroundIn the pediatric cancer neuroblastoma (NB), patients are stratified into low, intermediate or high‐risk subsets based in part on MYCN amplification status. While MYCN amplification in general predicts unfavorable outcome, no clinical or genomic factors have been identified that predict outcome within these cohorts of high‐risk patients. In particular, it is currently not possible at diagnosis to determine which high‐risk neuroblastoma patients will ultimately fail upfront therapy.Experimental designWe analyzed the prognostic potential of most published gene expression signatures for NB and developed a new prognostic signature to predict outcome for patients with MYCN amplification. Network and pathway analyses identified candidate therapeutic targets for this MYCN‐amplified patient subset with poor outcome.ResultsMost signatures have a high capacity to predict outcome of unselected NB patients. However, the majority of published signatures, as well as most randomly generated signatures, are highly confounded by MYCN amplification, and fail to predict outcome in subpopulations of high‐risk patients with MYCN‐amplified NB. We identify a MYCN module signature that predicts patient outcome for those with MYCN‐amplified tumors, that also predicts potential tractable therapeutic signaling pathways and targets including the DNA repair enzyme Poly [ADP‐ribose] polymerase 1 (PARP1).ConclusionMany prognostic signatures for NB are confounded by MYCN amplification and fail to predict outcome for the subset of high‐risk patients with MYCN amplification. We report a MYCN module signature that is associated with distinct patient outcomes, and predicts candidate therapeutic targets in DNA repair pathways, including PARP1 in MYCN‐amplified NB.
Is momentum trading profitable from Shari'ah compliant stocks?
Authors: Li Bob , Ee Mong Shan , Rashid Mamunur 
Published: August 2016

AbstractThis research offers fresh evidence supporting the pervasiveness of the momentum effect. Two decades after the momentum profitability firstly documented by Jegadeesh and Titman (1993), yet little research has been specifically devised for the momentum profitability on Shari'ah compliant stocks. We assess the momentum profitability over the Shari'ah compliant stocks in a Malaysian setting. We find evidence of strong return persistence as far as toward four‐year holding period. Interestingly, no significant momentum returns are found among the conventional stocks. Upon further exploration we find neither an industry‐driven momentum effect nor the small size firms can account for the momentum returns. Using return persistency formation criteria, we further find that underreaction seems to well fit in explaining this unique long lasting momentum profitability.
Metal-containing coals of the East Donetsk Basin: regularities of formation and integrated-use prospects
Authors: Gamov M.I. , Levchenko S.V. , Rylov V.G. , Rybin I.V. , Trufanov A.V. 
Published: August 2016

Abstract
We consider the regularities of formation and prospects for the integrated use of fossil coals of two conjugate lithogeodynamic groups: East Donetsk Basin group of coal-bearing deposits of suprarift genesis and platform group of coals of the southern slope of the Voronezh anteclise. The paleogeographic and lithologo-geochemical environments of formation of coal deposits in the Millerovo coal-bearing district and in the northeastern folded area of the Donetsk Basin are analyzed. The geochemical characteristics of coals with high contents of trace elements and their localization in the coal-bearing series (at the sites with hydrocarbon fluidization of coal seams) are discussed. We also assess the prospects for using coals and products of their conversion and burning as a specific mineral raw material containing nonferrous, rare, and noble metals.
Lithium-containing Na–Fe-amphibole from cryolite rocks of the Katugin rare-metal deposit (Transbaikalia, Russia): chemical features and crystal structure
Authors: Sharygin V.V. , Zubkova N.V. , Pekov I.V. , Rusakov V.S. , Ksenofontov D.A. , Nigmatulina E.N. , Vladykin N.V. , Pushcharovsky D.Yu. 
Published: August 2016

Abstract
Detailed chemical and structural studies were carried out for Li–Na–Fe-amphibole from cryolite rocks of the Katugin deposit, Transbaikalia. The rocks contain 30–70 vol.% cryolite, mafic minerals as Fe-silicates (Li–Na–Fe-amphibole, Li-containing fluorannite, and bafertisite), oxides (magnetite, ilmenite, pyrochlore, cassiterite, and others), and sulfides (sphalerite, pyrite, and chalcopyrite). Quartz, K-feldspar, polylithionite, REE-fluorides, and albite occur as minor or accessory phases. The chemical composition of amphibole (wt.%) varies as follows: SiO2, 48.5–48.9; TiO2, 0.4–0.8; Al2O3, 1.6–2.2; Fe2O3, 15.9–17.1; FeO, 17.6–18.4; MnO, 0.8–0.9; ZnO, 0.3–1.1; MgO, 0.2–0.3; CaO, &lt;0.1; Na2O, 8.4–8.7; K2O, 1.4–1.5; Li2O, 0.6–0.8; H2O, 0.7–0.8; and F, 2.2–2.5. The amphibole has a specific composition intermediate among the F–Fe members of the Na-amphibole subgroup: 40–45 mol.% ferro-ferri-fluoro-nybøite, 40–45 mol.% ferro-ferri-fluoro-leakeite, and 10–20 mol.% fluoro-riebeckite ± fluoro-arfvedsonite. The mineral is monoclinic, space group C2/m, a = 9.7978(2), b = 17.9993(3), c = 5.33232(13) Å, β = 103.748(2)º, V = 913.43(3) Å3, and Z = 2. The structural formula of Li–Na–Fe-amphibole is (Na0.46K0.24□0.30)Na2.00(Fe0.952+Mg0.05)2⋅(Fe0.953+Ti0.025Mg0.025)2(Li0.37Fe0.482+Mn0.10Zn0.05)[(Si0.91Al0.09)4Si4O22](F0.58(OH)0.42)2. Raman and Mössbauer spectroscopy data are given for this amphibole.
Paleobathymetry of the Late Jurassic–Neocomian basin in northern West Siberia and the impact of natural processes
Authors: Ershov S.V. 
Published: August 2016

Abstract
Paleobathymetrical reconstructions were performed for the Volgian–Neocomian basin in northern West Siberia. The proposed technique takes into account a number of factors, such as the rates of basin subsidence and sedimentation, sediment lithification and types of lithology, sea level changes, and isostasy. The role of each factor controlling the depth of the paleobasin is considered. The study reveals several stages of formation of the Neocomian clinoform complex of West Siberia, with different regimes of basin subsidence, sedimentation, and isostatic compensation.
Oxygen isotope composition of diatoms from sediments of Lake Kotokel (Buryatia)
Authors: Kostrova S.S. , Meyer H. , Tarasov P.E. , Bezrukova E.V. , Chapligin B. , Kossler A. , Pavlova L.A. , Kuzmin M.I. 
Published: August 2016

Abstract
This is a summary of new oxygen isotope record of diatoms from Lake Kotokel sediments, with implications for responses of the lake system and its environment to global change over the past 46 kyr. Fossil diatoms in all samples are free from visible contamination signatures and contain no more than 2.5% Al2O3, which ensures reliable reconstructions. The δ18O values in diatoms vary between +23.7 and +31.2‰ over the record. The results present mainly diatom assemblages of summer blooming periods, except for the time span between 36 and 32 kyr, when the isotopic signal records mainly a shift from summer to spring blooming conditions. Possible water temperature changes only partly explain the changes in the isotopic record. The observed isotopic patterns are produced mainly by isotope changes in lake water in response to variations in air temperature, hydrology, and atmospheric circulation in the region. During Marine Isotope Stage (MIS) 2 (Last Glacial maximum), high δ18Odiatom resulted from rapid evaporation and low fluvial inputs. The high δ18Odiatom values of about +29 to +30‰ during the first half of MIS 1 (Holocene interglacial) suggest an increased share of summer rainfalls associated with southern/southeastern air transport. The δ18Odiatom decrease to +24‰ during the second half of MIS 1 is due to the overall hemispheric cooling and increased moisture supply to the area by the Atlantic air masses. The record of Lake Kotokel sediments provides an example of complex interplay among several climatic/environmental controls of δ18Odiatom during the Late Pleistocene and the Holocene.
Seismic stratigraphy, formation history and gas potential of the Nadym–Pur interfluve area (West Siberia)
Authors: Kontorovich V.A. , Ayunova D.V. , Gubin I.A. , Ershov S.V. , Kalinin A.Yu. , Kalinina L.M. , Kanakov M.S. , Solov’ev M.V. , Surikova E.S. , Shestakova N.I. 
Published: August 2016

Abstract
The study presents a seismic and geological characterization of the Meso-Cenozoic sedimentary cover of the Nadym–Pur interfluve area and discusses the morphology of the Jurassic and Aptian–Albian–Cenomanian sedimentary complexes, formation history of structures, and geologic processes responsible for the formation of Cenomanian gas accumulations.
Current generation by deep-water breaking waves
Authors: Pizzo N. E. , Deike Luc , Melville W. Kendall 
Published: August 2016

We examine the partitioning of the energy transferred to the water column by deep-water wave breaking; in this case between the turbulent and mean flow. It is found that more than 95 % of the energy lost by the wave field is dissipated in the first four wave periods after the breaking event. The remaining energy is in the coherent vortex generated by breaking. A scaling argument shows that the ratio between the energy in this breaking generated mean current and the total energy lost from the wave field to the water column due to breaking scales as $(hk)^{1/2}$, where $hk$ is the local slope at breaking. This model is examined using direct numerical simulations of breaking waves solving the full two-phase air–water Navier–Stokes equations, as well as the limited available laboratory data, and good agreement is found for strong breaking waves.
Evaluation of Sample Preparation Protocols for the 14C Dating of Tupiguarani Pottery in Southeastern Brazil
Authors: Oliveira Fabiana M , Macario Kita D , Pereira Bruna B , Buarque Angela , Chivall David , Alves Eduardo Q , Ramsey Christopher Bronk 
Published: August 2016

AbstractThis study evaluates the radiocarbon dating of ceramic samples from Tupiguarani sites in Brazil, a settlement type dating up to 3000 cal BP. In this work, residues from ceramic samples from four archaeological sites in Rio de Janeiro (Morro Grande, Serrano, Barba Couto, and Bananeiras) were analyzed. In order to identify the most suitable sample preparation protocols, the humic fraction was isolated from the bulk material at the Oxford Radiocarbon Accelerator Unit (ORAU), whereas the acid-base-acid (ABA) residue fraction method was applied at the Radiocarbon Laboratory of the Fluminense Federal University (LAC-UFF). The dating results were compared to the current knowledge about the occupational periods of the sites. For the Morro Grande site, the results of humic and ABA residue fractions show a difference of more than 1500 yr. For the Serrano site, the 14C ages obtained from the two pretreatments are identical, and as with the Barba Couto and Bananeiras sites, indicate an occupation during the Brazilian colonial period of the 16th century AD and are compatible with the archaeological data.
Radiocarbon Marine Reservoir Effect on the Northwestern Coast of Cuba
Authors: Diaz M , Macario K D , Gomes P R S , Álvarez-Lajonchere L , Aguilera O , Alves E Q 
Published: August 2016

AbstractThe regional component (∆R) of the marine reservoir effect (MRE), which is crucial for the accurate calibration of radiocarbon ages of marine-influenced samples, was determined for the Cuban northwestern coast. Fifteen different locations were studied by14C dating of pre-bomb known-age marine shells specimens of bivalves and gastropods from the Felipe Poey Museum collection. Accelerator mass spectrometry (AMS)14C measurements were performed at the Radiocarbon Laboratory of the Universidade Federal Fluminense (LAC-UFF) and mean ΔR values were estimated. The distribution of results indicates ∆R values from −46±38 to 140±5214C yr and a possible pattern related to the position along the coast and ocean dynamics. We present both mean values for each region and a general ∆R of 28±1314C yr for the northwestern coast of Cuba.
Macronutrient intake in advanced age: Te Puāwaitanga o Ngā Tapuwae Kia ora Tonu, Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ)
Authors: Wham Carol , Teh Ruth , Moyes Simon A. , Rolleston Anna , Muru-Lanning Marama , Hayman Karen , Adamson Ashley , Kerse Ngaire 
Published: August 2016

AbstractAs part of the 12-month follow-up of the longitudinal cohort study, Life and Living in Advanced Age: A Cohort Study in New Zealand, dietary intake was assessed in 216 Māori and 362 non-Māori octogenarians using repeat 24-h multiple pass recalls. Energy and macronutrient intakes were calculated, and food items reported were allocated to food groups used in the New Zealand Adult Nutrition Survey (NZANS). Intakes were compared with the nutrient reference values (NRV) for Australia and New Zealand. The median BMI was higher for Māori (28·3 kg/m2) than for non-Māori (26·2 kg/m2)P=0·007. For Māori, median energy intake was 7·44 MJ/d for men and 6·06 MJ/d for women with 16·3 % energy derived from protein, 43·3 % from carbohydrate and 38·5 % from fat. Median energy intake was 7·91 and 6·26 MJ/d for non-Māori men and women, respectively, with 15·4 % of energy derived from protein, 45 % from carbohydrate and 36·7 % from fat. For both ethnic groups, bread was the top contributor to energy and carbohydrate intakes. Protein came from beef and veal, fish and seafood, bread, milk and poultry with the order differing by ethnic groups and sex. Fat came mainly from butter and margarine. Energy-adjusted protein was higher for Māori than non-Māori (P=0·049). For both ethnic groups, the median energy levels were similar, percent carbohydrate tended to be lower and percent fat higher compared with adults aged >70 years in NZANS. These unique cross-sectional data address an important gap in our understanding of dietary intake in this growing section of our population and highlight lack of age-appropriate NRV.
Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial
Authors: Szymlek-Gay Ewa A. , Domellöf Magnus , Hernell Olle , Hurrell Richard F. , Lind Torbjörn , Lönnerdal Bo , Zeder Christophe , Egli Ines M. 
Published: August 2016

AbstractDifferent metabolic pathways of supplemental and fortification Fe, or inhibition of Zn absorption by Fe, may explain adverse effects of supplemental Fe in Fe-sufficient infants. We determined whether the mode of oral Fe administration or the amount habitually consumed affects Fe absorption and systemic Fe utilisation in infants, and assessed the effects of these interventions on Zn absorption, Fe and Zn status, and growth. Fe-sufficient 6-month-old infants (n72) were randomly assigned to receive 6·6 mg Fe/d from a high-Fe formula, 1·3 mg Fe/d from a low-Fe formula or 6·6 mg Fe/d from Fe drops and a formula with no added Fe for 45 d. Fractional Fe absorption, Fe utilisation and fractional Zn absorption were measured with oral (57Fe and67Zn) and intravenous (58Fe and70Zn) isotopes. Fe and Zn status, infection and growth were measured. At 45 d, Hb was 6·3 g/l higher in the high-Fe formula group compared with the Fe drops group, whereas serum ferritin was 34 and 35 % higher, respectively, and serum transferrin 0·1 g/l lower in the high-Fe formula and Fe drops groups compared with the low-Fe formula group (allP<0·05). No intervention effects were observed on Fe absorption, Fe utilisation, Zn absorption, other Fe status indices, plasma Zn or growth. We concluded that neither supplemental or fortification Fe nor the amount of Fe habitually consumed altered Fe absorption, Fe utilisation, Zn absorption, Zn status or growth in Fe-sufficient infants. Consumption of low-Fe formula as the only source of Fe was insufficient to maintain Fe stores.
Retirement plans and active ageing: perspectives in three countries
Authors: PRINCIPI ANDREA , SANTINI SARA , SOCCI MARCO , SMEATON DEBORAH , CAHILL KEVIN E. , VEGERIS SANDRA , BARNES HELEN 
Published: August 2016

ABSTRACTThis study explores whether the plans of older workers on the cusp of retirement are in line with the active ageing agenda set by policy makers in Europe. The study was carried out in Italy, England, and the United States of America (USA). A total of 133 older workers who planned to retire within the next 10–12 months were interviewed (55 in England, 40 in Italy and 38 in the USA) between May 2014 and early 2015 using common semi-structured questions. Active Ageing Index dimensions were used to gauge the orientation of older people towards their retirement. The results of the study suggest that, with some differences, retirement plans of interviewees were substantially consistent with the active ageing perspective. However, some challenges were highlighted, including the need for governments to do more to promote genuine freedom of choice in relation to leaving the labour market, and to provide greater support for informal family carers. Findings also pointed to the need to measure active ageing in connection with individual wellbeing,e.g.by including indicators of leisure activities and by considering the re-weighting of employment and informal care dimensions. Companies could also provide more support during the retirement transition, with opportunities for maintained social connection with former colleagues, and help in making and fulfilling retirement plans.