bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panfacial Fat Injection Approach in Young Asian Patients for Facial Contouring: A Goal-Oriented Classification Method Based on the Facial Fat Compartments Theory
Authors: Li Zhanqiang , Li Jie , Ma Jiguang , Li Xin , Wang Keming , Wang Chunhu , Qi Zuoliang 
Published: April 2017

Background:
In Asia, young patients tend to undergo panfacial fat injection for facial contouring rather than for rejuvenation. Although the procedure is widely performed, there is no single approach that has been shown to have consistent results.

Method:
One personalized approach based on the facial fat compartment theory is presented here. Under the theory of facial fat compartments, the injection area is classified into functional zones and transition zones. A retrospective review of 105 cases over 6 years was performed to evaluate the effectiveness of this approach.

Results:
Follow-up ranged from 6 to 47 months. Satisfactory results were achieved in 96 percent of cases. Typical cases were also reviewed.

Conclusions:
In the authors’ view, this approach is safe and easy to learn, and produces aesthetically satisfactory results. The approach is stable, and satisfactory clinical results were achieved under the guidance of the facial fat compartment theory, which in turn verified the accuracy of this theory.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, V.
Current Status of Parkinsonism-Related Adverse Events and Associated Drugs in Korea
Authors: Kim Siin , Suh Hae Sun 
Published: April 2017

Objective
The aim of the study was to explore the current status of drug-induced parkinsonism and drugs possibly related to drug-induced parkinsonism in Korea.

Methods
We conducted a cross-sectional study using the Korea Adverse Event Reporting System database between July 1, 2010, and June 30, 2015. We identified all adverse event reports associated with parkinsonism.

Results
There were 1402 adverse event reports associated with parkinsonism. The number of adverse event reports has increased annually. Among the 1499 drugs associated with parkinsonism, the most common were metoclopramide (49.77%) and paliperidone (16.14%). The major therapeutic groups (the third level of the Anatomical Therapeutic Chemical code) were propulsives (53.87%) and antipsychotics (35.58%). The mean time of onset of parkinsonism was 34.9 days. However, the time of onset of parkinsonism varied by drug, for example, it was 4.6 days for metoclopramide and 37.2 days for paliperidone.

Conclusions
Metoclopramide and antipsychotics were reported in most adverse event reports associated with parkinsonism in Korea.
Intravenous Administration Errors Intercepted by Smart Infusion Technology in an Adult Intensive Care Unit
Authors: Ibarra-Pérez Rebecca , Puértolas-Balint Fabiola , Lozano-Cruz Elizabeth , Zamora-Gómez Sergio E. , Castro-Pastrana Lucila I. 
Published: April 2017

Objectives
The aim of the study was to investigate the efficacy of intravenous (IV) smart pumps with drug libraries and dose error reduction system (DERS) to intercept programming errors entailing high risk for patients in an adult intensive care unit (ICU).

Methods
A 2-year retrospective study was conducted in the adult ICU of the Hospital Juárez de México in Mexico City to evaluate the impact of IV smart pump/DERS (Hospira MedNet) technology implementation. We conducted a descriptive analysis of the reports generated by the system’s software from April 2014 through May 2016. Our study focused on the upper hard limit alerts and used the systems’ variance reports and IV Medication Harm Index methodology to determine the severity of the averted overdoses for medications with the highest number of edits.

Results
The system monitored 124,229 infusion programs and averted on 36,942 deviations of the preset safe limits. Upper hard limit alerts accounted for 26.4% of pump reprogramming events. One hundred sixty-six significant administration errors were intercepted and prevented, and IV Medication Harm Index analysis identified 83 of them as highest-risk averted overdoses with insulin accounting for 51.8% of those. The rate of compliance with the safety software during the study period was 69.8%.

Conclusions
Our study contributes additional evidence of the impact of IV smart pump/DERS technology. These pumps effectively intercepted severe infusion errors and significantly prevented adverse drug events related to dosing. Our results support the implementation of this technology in ICUs as a minimum safety standard and could help drive an IV infusion safety initiative in Mexico.
Bowel Angioedema Associated With Iodinated Contrast Media
Authors: Seo Nieun , Chung Yong Eun , Lim Joon Seok , Song Mi Kyung , Kim Myeong-Jin , Kim Ki Whang 
Published: April 2017

Objective
Bowel angioedema is an acute adverse reaction to iodinated contrast media (CM) that involves the gastrointestinal tract. We aimed to investigate the incidence and predisposing factors of iodinated CM-associated bowel angioedema during computed tomography (CT) examinations.

Materials and Methods
This study was approved by our institutional review board, and informed consent was waived due to its retrospective design. From July 2013 to July 2015, adult patients with a history of adverse reactions to iodinated CM during CT (group A, n = 427) and patients without adverse reactions matched for age and sex with the propensity-score matching method (group B, n = 427) were studied. Contrast media–associated bowel angioedema was determined when bowel wall thickness increased after contrast enhancement compared with the precontrast scan. Potential predisposing factors including patient demographics, symptoms and time of adverse reactions, and CM-related factors were compared between patients with and without angioedema in group A. In addition, the incidence of bowel angioedema was compared between groups A and B.

Results
The incidence of CM-associated bowel angioedema in group A was 3.3% (14/427) in the per-patient analysis and 2.6% (15/578) in the per-examination analysis. The CM–associated bowel angioedema involved the distal duodenum and/or proximal jejunum and showed long-segmental circumferential bowel wall thickening on CT. None of the studied predisposing factors was different between patients with and without bowel angioedema (P > 0.05). The incidence of CM-associated bowel angioedema in group B was 1.9% (8/427) and 1.7% (8/458) for per-patient and per-examination analyses, respectively, and these rates were not significantly different between groups A and B (P = 0.346 and P = 0.370, respectively).

Conclusions
The incidence of CM-associated bowel angioedema during CT was 1.7% to 3.3%, and none of the studied predisposing factors was associated with bowel angioedema.
Improved Retention of Chest Compression Psychomotor Skills With Brief “Rolling Refresher” Training
Authors: Niles Dana E. , Nishisaki Akira , Sutton Robert M. , Elci Okan U. , Meaney Peter A. , O'Connor Kathleen A. , Leffelman Jessica , Kramer-Johansen Jo , Berg Robert A. , Nadkarni Vinay 
Published: April 2017

Introduction
High-quality cardiopulmonary resuscitation (CPR) is critical to improve survival from cardiac arrest. However, cardiopulmonary resuscitation knowledge and psychomotor skill proficiency are transient. We hypothesized that brief, in situ refresher training will improve chest compression (CC) psychomotor skill retention for bedside providers.

Methods
Nurses completed a baseline skill evaluation of CC quality 6 months after traditional basic life support recertification. Data collected using ResusciAnne with SkillReporter included the following: CC depth, rate, complete release, and correct hand position. Total compliance was defined as 100% CC with depth of 50 mm or greater, rate of 100/min or greater, and more than 90% complete release. After the baseline evaluation, the subjects completed “Rolling Refresher” (RR) CC psychomotor training using audiovisual feedback every 2 to 3 months for 12 months until 30 seconds of CCs fulfilling total compliance criteria was achieved. Chest compression quality evaluations were repeated twice (“RR 6 month” and “RR 12 month” evaluation) after implementation of RR program.

Results
Thirty-seven providers enrolled and completed the baseline evaluation. Mean depth was 36.3 (9.7) mm, and 8% met criteria for depth, 35% for rate, and 5% for total compliance. After RRs were implemented, CC quality improved significantly at RR 6-month evaluation: odds ratio for meeting criteria were the following: depth of 35.1 (95% confidence interval = 2.5496, P = 0.009) and total compliance of 22.3 (95% confidence interval = 2.1239, P = 0.010). There was no difference in CC quality at RR 12-month versus RR 6-month evaluation.

Conclusions
Retention of CC psychomotor skill quality is limited to 6 months after traditional basic life support recertification. Rolling Refresher CC training can significantly improve retention of CC psychomotor skills. Whether CC skills are improved, maintained, or deteriorate after 12 months of Refresher training and optimal frequency of Refreshers is unknown.
Colovesical Fistula Complicating Diverticular Disease: A 14-Year Experience
Authors: Badic Bogdan , Leroux Geoffroy , Thereaux Jérémie , Joumond Aurélien , Gancel Charles H. , Bail Jean P. , Meurette Guillaume 
Published: April 2017

Objective:
Colovesical fistulas (CVF) constitute the most common type of spontaneously occurring fistulas associated with diverticular disease. One-stage laparoscopic resection has been shown to be feasible, but studies comparing this approach to open surgery are scarce. The aim of this study was to compare the clinical outcomes of open and laparoscopic surgery for CVF of diverticular origin.

Materials and Methods:
From January 2000 to July 2014, 37 colectomies were performed for diverticular disease–related CVF. Twenty-eight patients who underwent resection and primary anastomosis were divided in 2 groups: the laparoscopic surgery group (group A) and the open surgery group (group B). We have analyzed the following parameters: operative time, complication rate, hospital stay, recurrence, and early mortality rate.

Results:
Groups A and B were comparable in terms of age, sex, diverticulitis episodes, previous abdominal surgery, and body mass index.
The mean duration of surgery was significantly shorter in group B: 175 versus 237 minutes (P=0.011). There was a faster recovery of gastrointestinal transit in group A (2 vs. 13; P=0, 0002). However, there were no significant differences between the groups with respect to serious postoperative morbidity [(Clavien-Dindo scores of 3, 4, and 5) 4 vs. 0; P=0.098)] and with respect to hospital stay (10.5 vs. 9.5 d; P=0.537). There was no recurrence during a median follow-up of 12 months.

Conclusions:
Laparoscopic resection and primary anastomosis should be considered a safe and feasible option for the management of diverticular CVF. Despite progresses in minimally invasive colorectal surgery, the conversion rate and morbidity are still high.
Improving the treatment of infant pain
Authors: Moultrie Fiona , Slater Rebeccah , Hartley Caroline 
Published: April 2017

Purpose of review
Pain management presents a major challenge in neonatal care. Newborn infants who require medical treatment can undergo frequent invasive procedures during a critical period of neurodevelopment. However, adequate analgesic provision is infrequently and inconsistently provided for acute noxious procedures because of limited and conflicting evidence regarding analgesic efficacy and safety of most commonly used pharmacological agents. Here, we review recent advances in the measurement of infant pain and discuss clinical trials that assess the efficacy of pharmacological analgesia in infants.

Recent findings
Recently developed measures of noxious-evoked brain activity are sensitive to analgesic modulation, providing an objective quantitative outcome measure that can be used in clinical trials of analgesics.

Summary
Noxious stimulation evokes changes in activity across all levels of the infant nervous system, including reflex activity, altered brain activity and behaviour, and long-lasting changes in infant physiological stability. A multimodal approach is needed if we are to identify efficacious and well tolerated analgesic treatments. Well designed clinical trials are urgently required to improve analgesic provision in the infant population.
HiGlass: Web-based Visual Exploration and Analysis of Genome Interaction Maps
Authors: Kerpedjiev Peter , Abdennur Nezar , Lekschas Fritz , McCallum Chuck , Dinkla Kasper , Strobelt Hendrik , Luber Jacob M , Ouellette Scott , Azhir Alaleh , Kumar Nikhil , Hwang Jeewon , Lee Soohyun , Alver Burak H , Pfister Hanspeter , Mirny Leonid A , Park Peter J , Gehlenborg Nils 
Published: April 2017

AbstractWe present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, allowing users to combine various data types, synchronize multiple visualization modalities, and share fully customizable views with others. We demonstrate its utility in exploring different experimental conditions, comparing the results of analyses, and creating interactive snapshots to share with collaborators and the broader public. HiGlass is accessible online athttp://higlass.ioand is also available as a containerized application that can be run on any platform.
Mitochondrial genome variation affects the mutation rate of the nuclear genome inDrosophila melanogaster
Authors: Wolff Jonci N. , Camus M. Florencia , Dowling Damian K. , Rogell Björn 
Published: April 2017

AbstractMutations are the raw material for evolutionary change. While the mutation rate has been thought constant between individuals, recent research has shown that poor genetic condition can elevate the mutation rate. Mitonuclear genetic conflict is a potential source of poor genetic condition, and considering the high mutation rate of mitochondrial genomes, there should be ample scope for mitochondrial mutations to interfere with genetic condition, with concomitant effects on the nuclear mutation rate. Moreover, because theory suggests mitochondrial genetic effects will often be male-biased, such effects could be more strongly felt in males than females. Here, by mating irradiated maleDrosophila melanogasterto isogenic females bearing six distinct mitochondrial haplotypes, we tested whether mitochondrial genetic variation affects DNA repair capacity, and whether effects of mutation load on reproductive function are shaped by interactions between sex and mitochondrial haplotype. We found mitochondrial genetic effects on DNA repair, and that the mutational variance of reproductive fitness was higher in males bearing haplotypes characterized by high female fitness. These results suggest that mitochondrial genome variation may affect the mutation rate, and that induced mutations interact more strongly with male than female reproductive function. The potential for haplotype-specific effects on the nuclear mutation rate has broad implications for evolutionary dynamics, such as the accumulation of genetic load, adaptive potential, and the evolution of sexual dimorphism.
Classifying cancer genome aberrations by their mutually exclusive effects on transcription
Authors: Dayton Jonathan B. , Piccolo Stephen R. 
Published: April 2017

AbstractBackgroundMalignant tumors are typically caused by a conglomeration of genomic aberrations—including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug treatments are effective against tumors that harbor certain genomic aberrations. However, predictive aberrations (biomarkers) have not been identified for many tumor types and treatments. One way to address this problem is to examine the downstream, transcriptional effects of genomic aberrations and to identify characteristic patterns. Even though two tumors harbor different genomic aberrations, the transcriptional effects of those aberrations may be similar. These patterns could be used to inform treatment choices.MethodsWe used data from 9300 tumors across 25 cancer types from The Cancer Genome Atlas. We used supervised machine learning to evaluate our ability to distinguish between tumors that had mutually exclusive genomic aberrations in specific genes. An ability to accurately distinguish between tumors with aberrations in these genes suggested that the genes have a relatively different downstream effect on transcription, and vice versa. We compared these findings against prior knowledge about signaling networks and drug responses.ResultsOur analysis recapitulates known relationships in cancer pathways and identifies gene pairs known to predict responses to the same treatments. For example, in lung adenocarcinomas, gene-expression profiles from tumors with somatic aberrations in EGFR or MET were negatively correlated with each other, in line with prior knowledge that MET amplification causes resistance to EGFR inhibition. In breast carcinomas, we observed high similarity between PTEN and PIK3CA, which play complementary roles in regulating cellular proliferation. In a pan-cancer analysis, we found that genomic aberrations in BRAF and VHL exhibit downstream effects that are clearly distinct from other genes.ConclusionWe show that transcriptional data offer promise as a way to group genomic aberrations according to their downstream effects, and these groupings recapitulate known relationships. Our approach shows potential to help pharmacologists and clinical trialists narrow the search space for candidate gene/drug associations, including for rare mutations, and for identifying potential drug-repurposing opportunities.
RRM domain of ALS/FTD-causing FUS interacts with membrane: an anchor of membraneless organelles to membranes?
Authors: Lu Yimei , Lim Liangzhong , Song Jianxing 
Published: April 2017

Abstract526-residue FUS functions to self-assemble into reversible droplets/hydrogels, which could be further solidified into pathological fibrils. FUS is composed of N-terminal low-sequence complexity (LC); RNA-recognition motif (RRM) and C-terminal LC domains. FUS belongs to an emerging category of proteins which are capable of forming membraneless organelles in cells via phase separation. On the other hand, eukaryotic cells contain a large network of internal membrane systems. Therefore, it is of fundamental importance to address whether membraneless organelles can interact with membranes. Here we attempted to explore this by NMR HSQC titrations of three FUS domains with gradual addition of DMPC/DHPC bicelle, which mimics the bilayer membrane. We found that both N- and C-terminal LC domains showed no significant interaction with bicelle, but its well-folded RRM domain does dynamically interact with bicelle with an interface opposite to that for binding nucleic acids including RNA and ssDNA. If thisin vitroobservation also occurs in cells, to interact with membrane might represent a mechanism for dynamically organizing membraneless organelles to membranes to facilitate their physiological functions.
Learning and recognition of tactile temporal sequences by mice and humans
Authors: Bale Michael , Bitzidou Malamati , Pitas Anna , Brebner Leonie , Khazim Lina , Anagnou Stavros , Stevenson Caitlin , Maravall Miguel 
Published: April 2017

AbstractThe world around us is replete with stimuli that unfold over time. When we hear an auditory stream like music or speech or scan a texture with our fingertip, physical features in the stimulus are concatenated in a particular order, and this temporal patterning is critical to interpreting the stimulus. To explore the capacity of mice and humans to learn tactile sequences, we developed a task in which subjects had to recognise a continuous modulated noise sequence delivered to whiskers or fingertips, defined by its temporal patterning over hundreds of milliseconds. GO and NO-GO sequences differed only in that the order of their constituent noise modulation segments was temporally scrambled. Both mice and humans efficiently performed tactile sequence learning. Mouse performance relied mainly on detecting relative changes in noise amplitude over time, whereas humans appeared to have access to more cues, including the duration of noise modulation segments.
Regulation of intercellular TARGET OF MONOPTEROS 7 protein transport in theArabidopsisroot
Authors: Lu Kuan-Ju , De Rybel Bert , van Mourik Hilda , Weijers Dolf 
Published: April 2017

AbstractIntercellular communication coordinates hypophysis establishment in the Arabidopsis embryo. Previously, TARGET OF MONOPTEROS 7 (TMO7) was reported to be transported to the hypophysis, the founder cell of the root cap, and RNA suppression experiment implicated its function in embryonic root development. However, it remained unclear what protein properties and mechanisms mediate TMO7 protein transport, and what role the movement plays in development. Here, we report that in the post-embryonic root, TMO7 and its close relatives are transported into the root cap through plasmodesmata in a sequence, but not size dependent manner. We also show that nuclear residence is critical for TMO7 transport, and postulate that modification, potentially phosphorylation, labels TMO7 for transport. Additionally, three novel CRISPR/Cas9-inducedtmo7alleles confirmed a role in hypophysis division, but suggest complex redundancies with close relatives in root formation. Finally, we demonstrate that TMO7 transport is biologically meaningful, as local expression partially restores hypophysis division in a plasmodesmatal protein transport mutant. Our study identifies motifs and amino acids critical for TMO7 protein transport and establishes the importance of TMO7 in hypophysis and root development.Summary StatementUnique protein motifs, subcellular localization and post-translational modification, rather than protein size regulate plasmodesmatal transport of TMO7 family proteins during Arabidopsis root development.
Feel the way with a vibrotactile compass: Does a navigational aid aid navigation?
Authors: Weisberg Steven M. , Badgio Daniel , Chatterjee Anjan 
Published: April 2017

AbstractKnowing where north is provides a navigator with invaluable information for learning and recalling a space, particularly in places with limited navigational cues, like complex indoor environments. Although north is effectively used by orienteers, pilots, and military personnel, very little is known about whether non-expert populations can or will use north to create an accurate representation of an indoor space. In the current study, we taught people two non-overlapping routes through a complex indoor environment, with which they were not familiar – a university hospital with few windows and several turns. Along one route, they wore a vibrotactile compass on their arm, which vibrated continuously indicating the direction of north. Along the other route, they were only told where north was at the start of the route. At the beginning, the end, and back at the beginning of each route, participants pointed to well-known landmarks in the surrounding city and campus (external landmarks), and newly-learned landmarks in the hospital (internal landmarks). We found improved performance with the compass only for external landmarks, driven by people’s use of the availability of north to orient these judgments. No such improved orientation occurred for the internal landmarks. These findings reveal the utility of vibrotactile compasses for learning new indoor spaces. We speculate that such cues help users map new spaces onto familiar spaces or to familiar reference frames.