bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution characteristics and attribution analysis of runoff in the coal mining area in northwest China: A case study of the Kuye River Basin
Authors: Zhang Zhiqiang , Chen Liying , Zhang Fawang , Qian Jiazhong , Feng Yuqing , Han Shuangbao , Dai Fenggang 
Published: September 2024

ABSTRACT

The Kuye River Basin is the main coal-producing area in northwest China, and it is also a typical arid and semi-arid area. Under the combined influence of climate change and human activities, the runoff of the basin decreases noticeably. The Mann–Kendall trend test, the Hurst index, cumulative anomaly, and wavelet analysis were used to analyze the runoff evolution characteristics of the Kuye River, and the contributions of climate change and human activities to the runoff reduction were quantitatively separated by the slope-changing ratio of the cumulative quantity. The results showed that the runoff decreased significantly from 1970 to 2020, and there was an obvious abrupt change in 1996, while the change trends in precipitation and evaporation were not significant. The contributions of climate change and human activities to runoff reduction were 22.71 and 77.29%, respectively, and human activities have become the dominant factor in runoff variations. Coal mining and the implementation of soil and water conservation measures are considered to be the main human activities contributing to the reduction in runoff. In particular, mining activities reduce groundwater recharge to rivers, which provides a profound understanding of the effect of human activities in mining areas on runoff variation.
Estresse laboral em servidores de vigilância em instituições de ensino superior federal
Authors: Gomes Valter Gomes , José Lopes Agnaldo 
Published: September 2024

Estresse ocupacional é uma manifestação evidente em diversos segmentos profissionais e, entre profissionais de segurança, há uma predominância relevante. O objetivo desta revisão foi o de analisar o nível de estresse laboral em servidores de vigilância em instituições de ensino superior federal. A metodologia utilizada foi o da revisão integrativa de literatura por meio de consultas a materiais já publicados entre os anos de 2018 a 2023 e disponibilizados nas bases de dados da Scielo e PubMed. Conforme se pode compreender das informações descritas nesta revisão, embora haja deficiência acerca do objeto pretendido analisar, por analogia, é possível mencionar que os servidores de vigilância são suscetíveis à níveis elevados de estresse em instituições de ensino federal, em decorrência, principalmente, da natureza do trabalho, cujos fatores predisponentes estão associados às altas demandas de serviços, carga horária, conflito/incerteza, prevenção de ameaças e qualidade de clima organizacional. Tais condições implicam em prejuízo psicológico como depressão e ansiedade, bem como físicos com incidência de obesidade, diabetes, hipertensão e doenças cardiovasculares. Considerando que a profissão de segurança vem crescendo na última década, é fundamental o desenvolvimento de uma proposta de intervenção da medicina ocupacional, bem como a notificação de manifestações associadas ao estresse ocupacional, a fim de monitorar as patologias associadas a esta condição.
An Efficient and Cost-effective Modified Carbon Paste Electrodes for Diltiazem Hydrochloride Determination in Tablets
Authors: EL-Sanafery Safa S. , Elshafei Mostafa F. , Khalf Alla Perihan A. , Mohamed Gehad Genidy 
Published: September 2024

Background and Objective:
This study presented new sensitive and selective modified
carbon paste (MCPE) potentiometric sensors modified with different ion pairs for the determination
of the antihypertensive drug diltiazem hydrochloride (DTM-HCl) in biological fluids, pharmaceutical
preparations, and in its pure form.

Methods:
Plasticizers, ion pair type, ion pair content, response time, temperature, and pH were just a
few of the experimental factors evaluated that were found to affect electrode efficiency. The two
electrodes that show the best sensitivity were prepared by mixing diltiazem-tetraphenyl borate
(DTM-TPB) ion pair, graphite, and TCP or o-NPOE as a plasticizer.

Result:
Over the concentration ranges of 1.0x10-5–1.0x10-2, the produced electrodes I and II demonstrated
monovalent Nernstian responses of 55.7±0.902 and 57.6±0.451 mV decade-1. The selectivity
property of the suggested electrodes was used to study the interference ions. The concentration of
DTM-HCl in pharmaceutical formulations and biological fluids was measured using these modified
electrodes. During the validation procedure, metrics like linearity, accuracy, precision, limit of detection,
limit of quantification, and specificity were used.

Conclusion:
The obtained results showed good agreement with the HPLC technique as indicated by
the F and t-test values and can conclude the possibility of using this potentiometric method in the
routine analysis of DTM-HCl.
Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription
Authors: Sigler Sara , Abdel-Halim Mohammad , Fathalla Reem K. , Da Silva Luciana Madeira , Keeton Adam B. , Maxuitenko Yulia Y. , Berry Kristy L. , Zhou Gang , Engel Matthias , Abadi Ashraf H. , Piazza Gary A. 
Published: September 2024

Background:
Previous studies have reported that the cGMP-specific PDE5 isozyme is overexpressed
in colon adenomas and adenocarcinomas and essential for colon cancer cell proliferation, while PDE5 selective
inhibitors (e.g., sildenafil) have been reported to have cancer chemopreventive activity.

Aim:
This study aimed to determine the anticancer activity of a novel PDE5 inhibitor, RF26, using colorectal
cancer (CRC) cells and the role of PDE5 in CRC tumor growth in vivo.

Objective:
The objective of this study was to characterize the anticancer activity of a novel celecoxib derivative,
RF26, in CRC cells previously reported to lack COX-2 inhibition but have potent PDE5 inhibitory activity.

Methods:
Anticancer activity of RF26 was studied using human CRC cell lines. Its effects on intracellular cGMP
levels, cGMP-dependent protein kinase (PKG) activity, β-catenin levels, TCF/LEF transcriptional activity, cell
cycle distribution, and apoptosis were measured. CRISPR/cas9 PDE5 knockout techniques were used to determine
if PDE5 mediates the anticancer activity of RF26 and validate PDE5 as a cancer target.

Results:
RF26 was appreciably more potent than celecoxib and sildenafil to suppress CRC cell growth and was
effective at concentrations that increased intracellular cGMP levels and activated PKG signaling. RF26 suppressed
β-catenin levels and TCF/LEF transcriptional activity and induced G1 cell cycle arrest and apoptosis
within the same concentration range. CRISPR/cas9 PDE5 knockout CRC cells displayed reduced sensitivity to
RF26, proliferated slower than parental cells, and failed to establish tumors in mice.

Conclusion:
Further evaluation of RF26 for the prevention or treatment of cancer and studying the role of PDE5
in tumorigenesis are warranted.
Anti-neoplastic Properties of Boswellic Acids and their Novel Semi-synthetic Analogs: In vitro, In vivo and Clinical Evidence
Authors: Verma Mahima , Fatima Shireen , Ansari Irfan Ahmad 
Published: September 2024

Introduction:
Recently, Boswellia gum resin extract has been shown to exhibit therapeutic
properties against multiple inflammatory illnesses, comprising arthritis, asthma, diabetes, inflammatory
bowel disease, and different malignancies. There are growing shreds of evidence that Boswellia
extracts and their phytoconstituents could be used in adjuvant and combinatorial chemotherapeutic
approaches for the management and prevention of cancer.

Aim:
The principal objective of this comprehensive investigation is to offer up-to-date and in-depth
insights into the anticancer potential of boswellic acids along with their semisynthetic analog that are
novel and preventive/therapeutic substitutes for the management of cancer and inflammatory diseases
due to their strong potential.

Materials and Methods:
In the course of this review, a comprehensive compilation of In-vitro, Invivo,
and clinical evidence on the antineoplastic potential of boswellic acids was assembled through
systematic computerized searches utilizing platforms such as Google Scholar, PubMed, Sci-Hub, and
Research Gate.

Result:
Boswellic acids, the key compounds found in the resin of nearly all the species of the Boswellia
plant, have been reported to exhibit therapeutic effects by modulating various targets in different
disease conditions. Moreover, semisynthetic derivatives of boswellic acids show strong cytotoxic
effects, particularly those with cyanoenone moieties, endoperoxides, and hybrids, which exhibit enhanced
potency.

Conclusion:
In this review, we have sincerely highlighted the effectiveness of novel boswellic acids
as alternative preventive and therapeutic agents for the treatment of cancer and inflammatory conditions.
Their strong anticancer potential could provide a basis for promising future direction to develop
potent anticancer drugs for human malignancies.
Kinetic Adsorption Studies of Cationic Dyes onto Molecular Sieve and Activated Carbons
Authors: Rong Lei , Tao Guanjie , He Xiaoxiao , Meng Zitian , Fathy Nady , Tao Yousheng 
Published: September 2024

Background:
Dye-containing wastewater causes irreparable damage to the ecological
water system. Although adsorbents are widely used for treating wastewater containing
dyes, the comparative investigation on these materials is still insufficient for their wide
applications in the industries.

Objective:
With the aim of comparing efficient and fast adsorbent materials for cationic
dyes, we analyzed and evaluated the adsorbents of the MCM-41 molecular sieve and activated
carbons.

Methods:
The adsorption performance was studied on the common colored organics, such
as cationic dyes of rhodamine B (RhB) and methylene blue (MB) dyes. The present work
examined the impact of experimental variables, including initial dye concentration, adsorption
time, and pH, on the adsorption process and performance, as well as the adsorption
kinetics of the diverse adsorbents towards two cationic dyes.

Results:
MCM-41 molecular sieves showed relatively high adsorption capacity for RhB
and AC-2, which made their adsorption capacity for MB much higher than that of MCM-
41 molecular sieves. A comprehensive analysis was conducted using pseudo-first-order
and pseudo-second-order to decipher the mechanism of dye adsorption. The heterogeneous
adsorption mechanism could explain the dye adsorption behavior of MCM-41 molecular
sieve and activated carbons.

Conclusion:
The results demonstrated the influence of the pore structure and surface properties
of the adsorbents on the adsorption capacity of dye molecules in an aqueous solution.
For the initial concentration of cationic dye solutions of 20 mg/L, the MCM-41 molecular
sieve had a MB adsorption capacity of 130.8 mg/g under alkaline conditions at pH=10,
while the activated carbon adsorbents showed a stable MB adsorption capacity of 266.6
mg/g under different pH conditions, proving their applicability in treating wastewater containing
dyes under different acid/base environments.
Pengaruh Relationship Marketing Dan Customer Perceived Value Terhadap Repurchase Intention Dimediasi Oleh Customer Loyalty
Authors: Marpaung Putri Nauli , Arif Moh. Erfan 
Published: September 2024

The objective of this study is to identify and explain the effect of relationship marketing on repurchase intention, the effect of perceived value on repurchase intention, the effect of relationship marketing on customer loyalty, the effect of perceived value on customer loyalty, the effect of customer loyalty on repurchase intention, the influence of relationship marketing on repurchase intention through customer loyalty, and the influence of perceived value on repurchase intention through customer loyalty. Using purposive sampling technique, 190 people with the minimum age of sixteen years who had bought the products of Emina more than once were selected as the respondents. The data of this explanatory research was acquired from Likert-scaled questionnaires and processed using path analysis in SPSS ver. 25. This study finds that relationship marketing does not significantly affect repurchase intention, perceived value significantly affects repurchase intention, relationship marketing significantly affects customer loyalty, perceived value significantly affects customer loyalty, customer loyalty significantly affects repurchase intention, customer loyalty mediates the effect of relationship marketing on repurchase intention, and that customer loyalty mediates the effect of perceived value on repurchase intention.

Abstrak
Penelitian ini bertujuan untuk mengetahui dan menjelaskan: Pengaruh relationship marketing terhadap repurchase intention, pengaruh perceived value terhadap repurchase intention, pengaruh relationship marketing terhadap customer loyalty, pengaruh perceived value terhadap customer loyalty, pengaruh customer loyalty terhadap repurchase intention, pengaruh relationship marketing terhadap repurchase intention melalui customer loyalty, dan pengaruh perceived value terhadap repurchase intention melalui customer loyalty. Penelitian ini merupakan penelitian explanatory research dengan menggunakan kuesioner bersekala likert sebagai alat pengumpulan data. Pengumpulan sampel menggunakan teknik purposive sampling dengan karakteristik responden wanita berusia > 16 tahun dan telah membeli produk Emina lebih dari satu kali. Jumlah sampel yang digunakan dalam penelitian ini adalah sebanyak 190 responden. Data yang didapat kemudian diolah menggunakan software SPSS ver.25 menggunakan analisis jalur. Hasil penelitian ini menunjukan bahwa tidak terdapat pengaruh yang signifikan relationship marketing terhadap repurchase intention, terdapat pengaruh signifikan perceived value terhadap repurchase intention, Terdapat pengaruh signifikan relationship marketing terhadap customer loyalty, Terdapat pengaruh signifikan perceived value terhadap customer loyalty, Terdapat pengaruh signifikan customer loyalty terhadap repurchase intention, Customer loyalty dapat memediasi hubungan relationship marketing dan repurchase intention, dan Customer loyalty dapat memediasi hubungan perceived value dan repurchase intention.
Faktor-Faktor yang Mempengaruhi Pengontrolan Tekanan Darah pada Penderita Hipertensi
Authors: Priyono Nur Nabila Putri , Ardiansyah Muhammad Fikri Dwi , Naryati Naryati 
Published: September 2024

ABSTRAKLatar Belakang: Pengontrolan tekanan darah pada penderita hipertensi dapat dilakukan dengan cara penurunan berat badan, olahraga, pengaturan diet rendah garam, memperbaiki gaya hidup yang kurang sehat, dan terapi farmakologis. Penelitian sebelumnya mendapati bahwa usaha pengontrolan tekanan darah dapat dipengaruhi oleh beberapa faktor, seperti sikap, pengetahuan, dukungan keluarga dan kepatuhan pengobatan. Faktor-faktor tersebut dapat bervariasi tergantung pada budaya dan wilayah geografis pasien. Objektif: Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi pengontrolan tekanan darah pada penderita hipertensi di wilayah Jakarta.Metode: Penelitian ini menggunakan desain deskriptif-analitik dengan pendekatan cross-sectional. Sebanyak 42 responden di wilayah Jagakarsa Jakarta selatan dipilih menggunakan metode simple random sampling dengan stratifikasi berdasarkan RW. Pengambilan data dilakukan pada Mei-Juni 2021 dengan teknik wawancara berdasarkan panduan yang telah disusun sebelumnya yang memiliki reliabilitas 0,954. Hasil: Hasil penelitian menggunakan analisis statistic Chi-Square diperoleh bahwa sikap (p-value = 0,047), pengetahuan (p-value = 0,040), dukungan keluarga (p-value = 0,025), dan kepatuhan pengobatan (p-value = 0,040) berhubungan secara signifikan dengan kemampuan mengontrol tekanan darah pasien dengan hipertensi.Implikasi Klinis: Studi ini menemukan bahwa terdapat hubungan yang signifikan antara sikap, pengetahuan, dukungan keluarga, ketaatan minum obat, dan pengendalian tekanan darah pada pasien hipertensi. Kata Kunci: Pengontrolan Tekanan Darah, Sikap, Pengetahuan, Dukungan Keluarga, Kepatuhan Pengobatan.
Computer Attack Model in Conditions of Limited Protection Capabilities and Construction of Predictive Models of Computer Incidents
Authors: Ермакова А.Ю. 
Published: September 2024

В работе предложена математическая модель компьютерной атаки в условиях ограниченной возможности защиты и рассмотрены вопросы построения экспериментальных прогнозных моделей инцидентов, связанных с уязвимостями информационных систем и моделей компьютерных атак, с целью майнинга криптовалют. Ранее автором разработана методика вычисления оценки уровня защищенности информационной системы (ИС) на основе анализа произошедших инцидентов, построения прогнозной модели в виде непрерывной функции от времени – функции рисков, и определение на этой основе параметра, характеризующего степень защищенности ИС – времени безопасной эксплуатации. Математическая модель компьютерной атаки построена с применением аппарата теории вероятности и комбинаторного анализа. Прогнозные модели появления инцидентов, связанных с уязвимостями информационных систем, и модели атак с целью майнинга криптовалют построены на основе разработанного ранее инструментария построения прогнозных моделей динамических систем. Получены оценки времени безопасной эксплуатации информационной системы, в отношении которой реализуются атаки с целью майнинга криптовалют.
The paper offers a mathematical model of a computer attack in conditions of limited protection capabilities and considers the issues of constructing experimental predictive models of incidents related to vulnerabilities of information systems and models of computer attacks for the purpose of mining cryptocurrencies. Previously the author developed a method of calculating the evaluation level of security of information systems (is) based on the analysis of the incidents, the forecasting model as a continuous function of time function of risk and the definition on the basis of a parameter characterizing the degree of protection of IP – time safe operation. The mathematical model of a computer attack is constructed using the apparatus of probability theory and combinatorial analysis. Predictive models for the occurrence of incidents related to information system vulnerabilities and attack models for mining cryptocurrencies are based on the previously developed tools for building predictive models of dynamic systems. Estimates of the time of safe operation of the information system, in respect of which attacks are implemented for the purpose of mining cryptocurrencies, are obtained.
Cross-platform Solution for Pipeline Telemetry Cabinets
Authors: Конотоп Д.Г. , Стефанюк А.Р. 
Published: September 2024

В статье обобщены функциональные требования к шкафам линейной телемеханики со стороны компании ПАО «Транснефть» для применения на объектах линейной телемеханики. Предложен единый подход к реализации этих требований на промышленных контроллерах, не зависящий от производителя контроллера.
The article summarizes the functional requirements of the «Transneft» company for pipeline telemetry cabinets to be used at the sites of a pipeline SCADA system. Common approach is proposed that uses industrial controllers and does not depend on the controller manufacturer.
THE USE OF UNMANNED HYDROMETEOROLOGICAL TOOLS IN APPLIED RADIO METEOROLOGY
Authors: Горелик А.Г. , Николаев А.В. , Ситников Н.М. , Чекулаев И.И. , Журавлева В.А. 
Published: September 2024

В статье обсуждаются вопросы получения беспилотными гидрометеорологическими средствами (БГС) оперативной информации о состоянии тропосферы при производстве сверхкраткосрочных и краткосрочных прогнозов погоды радиолокационным способом. Отмечено, что на базе беспилотных летательных аппаратов (БПЛА) могут быть созданы простые в использовании и сравнительно недорогие БГС для измерения пространственных распределений метеорологических параметров атмосферы и получения информации, обеспечивающей повышение вероятности распознавания опасных явлений погоды (ОЯП) и точности измерения пространственных параметров гидрометеоров радиолокационными станциями (РЛС). Авторами, предлагаются новые способы получения метеорологической информации с применением БГС, позволяющие повысить точность метеоданных, получаемых радиолокационным способом. Представлены результаты исследований, направленных на создание новых средств метеорологического обеспечения с использованием БПЛА. Приведены вертикальные распределения некоторых параметров атмосферы с борта БПЛА. Определены направления дальнейших исследований и разработок. Ожидаемым эффектом от применения БГС на государственной наблюдательной сети Росгидромета является повышение качества интерпретации метеоданных, получаемых с помощью РЛС.
The issues of operation information obtaining using unmanned hydrometeorological tools are discussed. This information will be used with radar method for ultra-short and short-term weather forecasts. It was noted that on the basis of unmanned aerial vehicles (UAVs), easy-to-use and relatively inexpensive hydrometeorological tools can be created. These tools can be used to measure the spatial distributions of meteorological parameters of the atmosphere and to obtain information that increases the probability of recognition of dangerous weather phenomena and the accuracy of measuring parameters of hydrometeors by radar stations. The authors propose new methods for obtaining meteorological information using unmanned aerial vehicles which can improve the accuracy of weather data obtained by the radar methods. The directions of further research and development are determined. The results of studies and developments of new means of meteorological support are discussed. Measurements of the vertical distributions of some atmospheric parameters using UAVs are presented. The expected effect of the use of unmanned hydrometeorological tools on the state monitoring network is to improve the quality of interpretation of meteorological radar data.
CREATION OF SPECIAL BATCHES AS A WAY TO IMPROVE THE RELIABILITY OF THE ELECTRONIC COMPONENTS FOR SPACE APPLICATIONS
Authors: Куклин В.И. , Орлов В.И. , Федосов В.В. 
Published: September 2024

Приведена краткая историческая справка этапов проводимых АО «ИТЦ – НПО ПМ» работ по обеспечению длительной работоспособности электронной компонентной базы (ЭКБ) космического применения. Показано, что создание специализированных испытательных технических центров (ИТЦ) – оптимальный подход к формированию партий ЭКБ уровня качества «Space». Определен дальнейший путь повышения надежности ЭКБ космического применения через совместную работу ИТЦ и заводов-производителей по формированию спецпартий.
A brief historical summary of the stages of work carried out by JSC «ITC – NPO PM» to ensure long-term operability of the electronic component base (ECB) for space applications is given. It is shown that the creation of specialized test technical centers (TTC) is the optimal approach to the formation of ECB batches of the «Space» quality level. A further way to improve the reliability of ECB for space applications through the joint work of TTC and manufacturing plants to form special parties has been determined.