bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Synthesis and Good Performance of TiO2/Nitrogen‐Doped Carbon Spheres as Anode Materials for Lithium Ion Batteries
Authors: Zhou Yinlong , Zhang Peigen , Sun Yan , Shen Yuhua , Xie Anjian 
Published: December 2017

AbstractA facile, efficient and short‐time shearing method was developed to synthesize TiO2 precursor, then followed by calcining in NH3 gas to obtain nitrogen‐doped carbon coated TiO2 (TiO2/N‐C) successfully. Interestingly, the prepared TiO2/N‐C nanospheres were assembled by many tiny nanoparticles (NPs) and possessed rough surface. When used as an anode material, the TiO2/N‐C exhibited reversible specific capacity of 277 mA h g−1 after 220 cycles at the current density of 0.6 C, indicating the superb cycle stability of TiO2/N‐C. And a good rate capability at different current densities was also obtained. The excellent performance of the TiO2/N‐C was due to the nitrogen‐doped carbon and assembly structure, which could enhance the electrical conductivity and buffer the volume expansion during the charge and discharge process. Furthermore, the tiny NPs can short the transportation path of lithium ions and the gaps produced between connective tiny NPs could accommodate the volume change. So, the method of high speed shearing has great potential in synthesizing other anode materials for lithium ion batteries.
An 8‐generation family with X‐linked Charcot–Marie–Tooth: Confirmation Of the pathogenicity Of a 3′ untranslated region mutation in GJB1 and its clinical features
Authors: Chen Dong‐Hui , Ma Maxwell , Scavina Mena , Blue Elizabeth , Wolff John , Karna Prasanthi , Dorschner Michael O. , Raskind Wendy H. , Bird Thomas D. 
Published: December 2017

ABSTRACTIntroduction: Mutations in gap junction protein beta 1 (GJB1) on the X chromosome represent one of the most common causes of hereditary neuropathy. We assessed manifestations associated with a rare 3′ untranslated region mutation (UTR) of GJB1 in a large family with X‐linked Charcot–Marie–Tooth disease (CMTX). Methods: Clinical, electrophysiological, and molecular genetic analyses were performed on an 8‐generation family with CMTX. Results: There were 22 affected males and 19 symptomatic females, including an 83‐year‐old woman followed for 40 years. Electrophysiological studies showed a primarily axonal neuropathy. The c.*15C>T mutation in the GJB1 3′ UTR was identified in 4 branches of the family with a log of odds (LOD) of 4.91. This created a BstE II enzyme recognition site that enabled detection by restriction digestion. Discussion: The c.*15C>T mutation in the GJB1 3′ UTR segregates with CMTX1 in 8 generations. Penetrance in males and females is essentially complete. A straightforward genetic method to detect this mutation is described. Muscle Nerve 57: 859–862, 2018
Potential Enhancement of Juvenile Mussel Production with Exogenous Cortisol Treatment of Fish Hosts
Authors: Nelson Jace M , Bringolf Robert B 
Published: December 2017

Abstract
Hatchery propagation plays an essential role in restoration or augmentation of freshwater mussel populations, which are among the most critically imperiled of all taxa. A unique feature of freshwater mussel life history is an obligate parasitic relationship with fish in which the larval mussels (glochidia) must attach to host fish and metamorphose to the juvenile stage. Hatcheries can produce large quantities of juvenile mussels for restoration and research purposes; however, in cases where suitable host fish species have not been identified, options for propagation are severely limited. Although specific biochemical mechanisms mediating metamorphosis remain largely unknown, previous research suggests that the plasma cortisol level in the host is an important factor. Manipulation of cortisol to induce or increase metamorphosis in otherwise marginal or non-host fish may provide a valuable tool in culturing mussel species for which the primary host(s) are unknown or prohibitively difficult to rear in a captive environment. The objective of the present study was to further investigate the potential for exogenous cortisol treatment to increase attachment and metamorphosis on marginal or non-host fish. Cortisol treatment (intraperitoneal injection) of known host species (Largemouth Bass Micropterus salmoides and Bluegill Lepomis macrochirus) did not affect attachment or metamorphosis; however, in non-hosts (Channel Catfish Ictalurus punctatus and Goldfish Carassius auratus) and marginal hosts (Blue Tilapia Oreochromis aureus × Nile Tilapia Oreochromis niloticus hybrids), attachment generally increased with increasing cortisol, though only significantly so in Goldfish. Metamorphosis was significantly increased on the marginal hosts but was not induced on the non-hosts. This study provides clear evidence that cortisol manipulation of marginal hosts can increase juvenile mussel production and may be an important tool to maximize propagation efforts, particularly for imperiled species.
Replacing Fish Oil with Hydrogenated Soybean Oils in Feeds for Yellowtail
Authors: Bergman Alexis M , Trushenski Jesse T , Drawbridge Mark 
Published: December 2017

Abstract
To assess the relative merits of monounsaturated fatty acid (MUFA)-rich versus saturated fatty acid (SFA)-rich lipids as alternatives to fish oil in aquafeeds, diets formulated for Yellowtail Seriola dorsalis—containing menhaden fish oil, fully hydrogenated soybean oil (high SFA content), partially hydrogenated soybean oil (high MUFA content), or blends of these soy-derived lipids (20/80, 40/60, 60/40, or 80/20)—were tested in a 7-week feeding trial. Juvenile fish (~11 g) were stocked in a semi-closed recirculating aquaculture system (15 fish/tank), diets were randomly assigned to tanks in triplicate (N = 3), and fish were fed in slight excess of estimated apparent satiation. Growth performance did not vary based on dietary SFA versus MUFA content, but performance was inferior among fish fed the soybean oil-based feeds relative to those fed the fish oil-based feed: weight gain was 714–770% versus 848%; specific growth rate was 4.03–4.16% versus 4.32% body weight/d; and feed conversion ratio was 1.30–1.38 versus 1.27. Generally, fillet fatty acid composition mirrored dietary composition except that the fillets of fish fed diets containing primarily fully hydrogenated soybean oil contained fewer SFAs and more long-chain polyunsaturated fatty acids (LC-PUFAs) than one would expect based on dietary fatty acid profiles. Fillets of fish that were fed partially hydrogenated soybean oil contained trans-fatty acids (0.02–0.06 g of trans fats per 100 g of fillet) but only at trace levels. Liver fatty acid profiles were less affected by dietary lipid source, but where differences existed, they followed patterns similar to those observed in fillets. Results suggest that blends of fully and partially hydrogenated soybean oils may yield slightly higher growth performance and fillet lipid content without accumulating enough trans fats to negatively affect consumers. Diets containing only fully hydrogenated soybean oil may slightly reduce lipid digestion in Yellowtail, but they mitigate LC-PUFA loss associated with fish oil sparing.
Optimizing Feeding Strategies for Yellowtail Jack at Winter Water Temperatures
Authors: Bansemer Matthew S , Stone David A J , D'Antignana Trent , Skordas Paul , Kuerschner Leigh , Currie Krishna-Lee 
Published: December 2017

Abstract
Recent research has primarily focused on optimizing diet formulations and feeding regimes for Yellowtail Jack Seriola lalandi (known as Yellowtail Kingfish in Australia) during warm, optimal water temperatures. Further research on these aspects of production is needed during cool, suboptimal winter water temperatures. In this 84-d study, the growth performance and feed efficiency of Yellowtail Jack (1.44 kg) fed a commercially formulated diet at seven feed rates, ranging from 0.1% of body weight (BW) 1 d/week to apparent satiation 6 d/week, at cool water temperatures (11.5–16°C) were investigated. Yellowtail Jack fed to apparent satiation 6 d/week exhibited significantly higher growth rates and significantly better feed conversion ratios than fish fed at lower feed rates. The maintenance requirement for fish fed the formulated diet was 0.2047% BW/d (digestible energy and protein maintenance requirements are 30.1 kJ and 0.82 g · kg fish−1 · d−1, respectively). To provide nutrition slightly above this rate and ensure growth, fish may be fed to apparent satiation 2 d/week. Feeding fish below this maintenance rate during winter is not recommended, as the study fish lost weight. Underfeeding may also manifest itself in nutrient deficiency symptoms and health problems. We recommend that fish be fed the formulated diet to apparent satiation 6 d/weekduring winter. We also recommend further research to validate the current results under commercial conditions.
What if there were no universities?
Authors: Vasbinder Jan W. 
Published: December 2017

AbstractTo a large extent, the pursuit of science takes place in universities. In this essay, I ask the following questions. Supposing there were no universities, and that all the knowledge mankind has ever collected and generated is somehow accessible, would we invent universities to make this knowledge available to address the problems humanity faces? What should those universities perform, and what role would science play in such universities? To look for answers to those questions, I consider the nature of the problems dealt with by science, the knowledge needed to address those problems, the gap between the two, the need for interdisciplinarity and the need to educate the leaders of the future, and finally, the boundaries of scientific knowledge.
Inclusion of 2,4‐Dihydroxybenzaldehyde and 2,4‐Dihydroxybenzaldoxime in Cadmium Coordination Polymer and Conversion of Guest Aldehyde to Oxime
Authors: Tarai Arup , Baruah Jubaraj B. 
Published: December 2017

AbstractA coordination polymer of cadmium nitrate with bridging ligand 1,3‐di(pyridin‐4‐yl)propane in which each cadmium ion has two chelated nitrate ions along with a water molecule is structurally characterised. Three component reactions of cadmium nitrate, 1,3‐di(pyridin‐4‐yl)propane together with 2,4‐dihydroxybenzaldehyde or 2,4‐dihydroxybenzaldoxime resulted in the formation of cadmium coordination polymers having 1,3‐di(pyridin‐4‐yl)propane as linkers encapsulating the aldehyde or the oxime in respective coordination polymer. These guest molecules are encapsulated between layers formed by hydrogen bonds among the chains of the coordination polymers where the nitro groups are vertically positioned in between the cationic chains assisting in formation of partitioned compartments to encapsulate guests. These guest included coordination polymers having the 2,4‐dihydroxybenzaldehyde or 2,4‐dihydroxybenzaldoxime guest molecules provided understanding on facilitation of the oximation reaction of aldehyde containing coordination polymer. Higher association ability of oxime over the aldehyde to the parent coordination polymer is found to be the driving force to facilitate the catalytic reaction.
Facile Synthesis of MoSx and MoSx‐rGO Composite: Excellent Electrocatalyst for Hydrogen Evolution Reaction
Authors: Ghosh Sourav , Azad Uday Pratap , Singh Ashish Kumar , Singh Akhilesh Kumar , Prakash Rajiv 
Published: December 2017

AbstractIn this work, one pot synthetic methodology was developed, wherein simple purging of H2S gas into a solution/dispersion of polyoxometalates in the absence as well as presence of reduced graphene oxide (rGO) at room temperature resulted in the formation of MoSx and MoSx‐rGO composites. Powder XRD, TEM, EDS elemental analysis, TGA, and XPS study reveal that as prepared samples mainly consist of nanocrystalline MoS3 particles whereas annealed samples mainly contain few layers of MoS2 nanosheets. Annealed samples exhibit better electrocatalytic activity towards hydrogen evolution reaction (HER) as compared to the as‐prepared samples. Among all the annealed samples, MoS2‐rGO nanocomposite exhibits superior catalytic activity for HER with lower onset overpotential and higher current density, as compared to other conventional MoS2. The Tafel slope of 41.7 mV/decade for MoS2‐rGO nanocomposite signifies that MoS2 catalyzed HER follows the Volmer‐Heyrovsky mechanism wherein, electrochemical desorption of hydrogen is the rate‐limiting step. Moreover, the integration of few layers of MoS2 and rGO enable remarkable long‐term electrochemical stability and showing negligible change in the current density even after 3000 cycles.
Copper‐Catalyzed Sonogashira Reaction in Water
Authors: Liu Yujia , Blanchard Vincent , Danoun Grégory , Zhang Zhaoyang , Tlili Anis , Zhang Wenlong , Monnier Florian , Van Der Lee Arie , Mao Jincheng , Taillefer Marc 
Published: December 2017

AbstractCopper‐catalyzed Sonogashira reaction has been realized under biphasic conditions (water / organic substrates) allowing decreasing the copper loading up to 0.02–0.2 mol %. A potential intermediate species of the reaction, corresponding to a copper cluster linked with acetylide moiety, has been identified.
Surface integrity generated with peripheral milling and the effect on low-cycle fatigue performance of aeronautic titanium alloy Ti-6Al-4V
Authors: Yang D. , Liu Z. 
Published: December 2017

ABSTRACTMachining-induced surface integrity has an important effect on reliability and service life of the components used in the aerospace industry where titanium alloy Ti-6Al-4V is widely applied. Characterisation of machining-induced surface integrity and revealing its effect on fatigue life are conducive to structural fatigue life optimisation design. In the present study, surface topography, residual stress, microstructure and micro-hardness were first characterised in peripheral milling of titanium alloy Ti-6Al-4V. Then, low-cycle fatigue performances of machined specimens were investigated on the basis of the tension-tension tests. Finally, the effects of surface integrity factors (stress concentration factor, residual stress and micro-hardness) on fatigue performances were discussed. Results show that stress concentration can reduce the fatigue life while increasing the residual compressive stress, and micro-hardness is beneficial to prolonging the fatigue life, but when the surface material of the specimen is subjected to plastic deformation due to yield, the residual stress on the surface is relaxed, and the effect on the fatigue performance is disappeared. Under the condition of residual stress relaxation, the stress concentration factor is the main factor to determine the low-cycle fatigue life of titanium alloy Ti-6Al-4V. While for the specimens with no residual stress relaxation, micro-hardness was the key factor to affect the fatigue life, followed by residual stress and stress concentration factor, respectively.
An unsettled debate: Key empirical and theoretical questions are still open
Authors: Vincini Stefano , Jhang Yuna , Buder Eugene H. , Gallagher Shaun 
Published: December 2017

AbstractDebates about neonatal imitation remain more open than Keven & Akins (K&A) imply. K&A do not recognize the primacy of the question concerning differential imitation and the links between experimental designs and more or less plausible theoretical assumptions. Moreover, they do not acknowledge previous theorizing on spontaneous behavior, the explanatory power of entrainment, and subtle connections with social cognition.
The right to inclusive education: why is there so much opposition to its implementation?
Authors: de Beco Gauthier 
Published: December 2017

AbstractAlthough the Convention on the Rights of Persons with Disabilities (CRPD) proclaims the right to inclusive education, and much attention is being given to the goal of inclusive education in debates on human rights, there are doubts as to whether this right has led to a new direction in policy-making. The under-researched question is: why is there so much opposition to the implementation of the right to inclusive education? This paper examines the question by distinguishing between both the concept and practice of inclusive education. Using a specific interdisciplinary approach in order to critically analyse a legal norm, the paper looks into the very meaning of inclusive education by utilising some central conclusions from disability studies to appraise the ideal of inclusive education, and seeks to resolve related challenges by drawing upon political philosophy to investigate pragmatic solutions to the obstacles to inclusive education. This paper claims that it is thereby possible to incorporate the element of actual achievability into such an ideal.
Central IGF1 improves glucose tolerance and insulin sensitivity in mice
Authors: Hong Hao , Cui Zhen-Zhong , Zhu Lu , Fu Shu-Ping , Rossi Mario , Cui Ying-Hong , Zhu Bing-Mei 
Published: December 2017

AbstractInsulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), and ICV injection of an anti-IGF1 antibody. Mice that over-expressed central IGF1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased Pomc levels in the hypothalamus, and increased UCP1 expression in brown fat tissue. This is the first study demonstrating that central IGF1 regulates several important metabolic functions.
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway
Authors: Yan Honglin , Rao Jie , Yuan Jingping , Gao Likun , Huang Wenxian , Zhao Lina , Ren Jiacai 
Published: December 2017

AbstractLong non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been demonstrated as an important regulator in diverse human cancers. However, its function and regulatory mechanism in ischemic stroke remains largely unknown. Here, we report that MEG3 is physically associated with microRNA-21 (miR-21), while miR-21 is downregulated following ischemia in the ischemic corein vitroandin vivo, which is opposite to MEG3. Besides, overexpression of miR-21 protects oxygen–glucose deprivation and reoxygenation (OGD/R)-induced apoptotic cell death. Furthermore, MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with programmed cell death 4 (PDCD4) mRNA for directly binding to miR-21, which mediates ischemic neuronal death. Knockdown of MEG3 protects against ischemic damage and improves overall neurological functionsin vivo. Thus, our data uncovers a novel mechanism of lncRNA MEG3 as a ceRNA by targeting miR-21/PDCD4 signaling pathway in regulating ischemic neuronal death, which may help develop new strategies for the therapeutic interventions in cerebral ischemic stroke.
RIPK3 promotes adenovirus type 5 activity
Authors: Weigert Melanie , Binks Alex , Dowson Suzanne , Leung Elaine Y. L. , Athineos Dimitris , Yu Xinzi , Mullin Margaret , Walton Josephine B. , Orange Clare , Ennis Darren , Blyth Karen , Tait Stephen W. G. , McNeish Iain A. 
Published: December 2017

AbstractOncolytic adenoviral mutants infect human malignant cells and replicate selectively within them. This induces direct cytotoxicity that can also trigger profound innate and adaptive immune responses. However, the mechanism by which adenoviruses produce cell death remains uncertain. We previously suggested that type 5 adenoviruses, including the E1A CR2 deletion mutant dl922-947, might induce a novel form of programmed death resembling necroptosis. Here we have investigated the roles of core necrosis proteins RIPK1, RIPK3 and MLKL in the cytotoxicity of dl922-947 and other adenovirus serotypes. By electron microscopy, we show that dl922-947 induces similar necrotic morphology as TSZ treatment (TNF-α, Smac mimetic, zVAD.fmk). However, dl922-947-mediated death is independent of TNF-α signalling, does not require RIPK1 and does not rely upon the presence of MLKL. However, inhibition of caspases, specifically caspase-8, induces necroptosis that is RIPK3 dependent and significantly enhances dl922-947 cytotoxicity. Moreover, using CRISPR/Cas9 gene editing, we demonstrate that the increase in cytotoxicity seen upon caspase inhibition is also MLKL dependent. Even in the absence of caspase inhibition, RIPK3 expression promotes dl922-947 and wild-type adenovirus type 5 efficacy both in vitro and in vivo. Together, these results suggest that adenovirus induces a form of programmed necrosis that differs from classical TSZ necroptosis.
Type I interferon-mediated autoinflammation due to DNase II deficiency
Authors: Rodero Mathieu P. , Tesser Alessandra , Bartok Eva , Rice Gillian I. , Della Mina Erika , Depp Marine , Beitz Benoit , Bondet Vincent , Cagnard Nicolas , Duffy Darragh , Dussiot Michael , Frémond Marie-Louise , Gattorno Marco , Guillem Flavia , Kitabayashi Naoki , Porcheray Fabrice , Rieux-Laucat Frederic , Seabra Luis , Uggenti Carolina , Volpi Stefano , Zeef Leo A H. , Alyanakian Marie-Alexandra , Beltrand Jacques , Bianco Anna Monica , Boddaert Nathalie , Brouzes Chantal , Candon Sophie , Caorsi Roberta , Charbit Marina , Fabre Monique , Faletra Flavio , Girard Muriel , Harroche Annie , Hartmann Evelyn , Lasne Dominique , Marcuzzi Annalisa , Neven Bénédicte , Nitschke Patrick , Pascreau Tiffany , Pastore Serena , Picard Capucine , Picco Paolo , Piscianz Elisa , Polak Michel , Quartier Pierre , Rabant Marion , Stocco Gabriele , Taddio Andrea , Uettwiller Florence , Valencic Erica , Vozzi Diego , Hartmann Gunther , Barchet Winfried , Hermine Olivier , Bader-Meunier Brigitte , Tommasini Alberto , Crow Yanick J. 
Published: December 2017

AbstractMicrobial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a panel of interferon-stimulated genes we identify two siblings and a singleton variably demonstrating severe neonatal anemia, membranoproliferative glomerulonephritis, liver fibrosis, deforming arthropathy and increased anti-DNA antibodies. In both families we identify biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity. We record increased interferon alpha protein levels using digital ELISA, enhanced interferon signaling by RNA-Seq analysis and constitutive upregulation of phosphorylated STAT1 and STAT3 in patient lymphocytes and monocytes. A hematological disease transcriptomic signature and increased numbers of erythroblasts are recorded in patient peripheral blood, suggesting that interferon might have a particular effect on hematopoiesis. These data define a type I interferonopathy due to DNase II deficiency in humans.