bluuebunny/crossref_metadata_2025_split huggingface dataset:
Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis
Authors: Toyoda Yu , Takada Tappei , Suzuki Hiroshi 
Published: April 2016

AbstractRecently, the International Agency for Research on Cancer issued a warning about the carcinogenicity of 1,2-dichloropropane (1,2-DCP) to humans based on an epidemiological study suggesting a relationship between the incidence of cholangiocarcinoma and occupational exposure to halogenated hydrocarbon solvent comprised mostly of 1,2-DCP. Although this dihaloalkane has been used in various industrial fields, there has been no biological evidence explaining the cholangiocarcinoma latency, as well as little understanding of general cholangiocarcinoma risk. In the present study, we explored the biliary excretion of 1,2-DCP metabolites by an untargeted metabolomics approach and the related molecular mechanism with in vitro and in vivo experiments. We hypothesized that the biliary excretion of carcinogens derived from 1,2-DCP contribute to the increased cholangiocarcinoma risk. We found that 1,2-DCP was conjugated with glutathione in the liver, and that the glutathione-conjugated forms of 1,2-DCP, including a potential carcinogen that contains a chloride atom, were excreted into bile by the bile canalicular membrane transporter, ABCC2. These results may reflect a risk in the backfiring of biliary excretion as a connatural detoxification systems for xenobiotics. Our findings would contribute to uncover the latent mechanism by which the chronic exposure to 1,2-DCP increases cholangiocarcinoma risk and future understanding of cholangiocarcinoma biology.
Crypt cells are involved in kin recognition in larval zebrafish
Authors: Biechl Daniela , Tietje Kristin , Gerlach Gabriele , Wullimann Mario F. 
Published: April 2016

AbstractZebrafish larvae imprint on visual and olfactory kin cues at day 5 and 6 postfertilization, respectively, resulting in kin recognition later in life. Exposure to non-kin cues prevents imprinting and kin recognition. Imprinting depends on MHC class II related signals and only larvae sharing MHC class II alleles can imprint on each other. Here, we analyzed which type of olfactory sensory neuron (OSN) detects kin odor. The single teleost olfactory epithelium harbors ciliated OSNs carrying OR and TAAR gene family receptors (mammals: main olfactory epithelium) and microvillous OSNs with V1R and V2R gene family receptors (mammals: vomeronasal organ). Additionally, teleosts exhibit crypt cells which possess microvilli and cilia. We used the activity marker pERK (phosphorylated extracellular signal regulated kinase) after stimulating 9 day old zebrafish larvae with either non-kin conspecific or food odor. While food odor activated both ciliated and microvillous OSNs, only the latter were activated by conspecific odor, crypt cells showed no activation to both stimuli. Then, we tested imprinted and non-imprinted larvae (full siblings) for kin odor detection. We provide the first direct evidence that crypt cells and likely a subpopulation of microvillous OSNs, but not ciliated OSNs, play a role in detecting a kin odor related signal.
The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats
Authors: Gris Georgia , Portillo-Salido Enrique , Aubel Bertrand , Darbaky Yassine , Deseure Kristof , Vela José Miguel , Merlos Manuel , Zamanillo Daniel 
Published: April 2016

AbstractE-52862 is a selective σ1R antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a potential first-in-class analgesic. Here, we investigated the effect of single and repeated administration of E-52862 on different pain-related behaviours in several neuropathic pain models in rats: mechanical allodynia in cephalic (trigeminal) neuropathic pain following chronic constriction injury of the infraorbital nerve (IoN), mechanical hyperalgesia in streptozotocin (STZ)-induced diabetic polyneuropathy and cold allodynia in oxaliplatin (OX)-induced polyneuropathy. Mechanical hypersensitivity induced after IoN surgery or STZ administration was reduced by acute treatment with E-52862 and morphine, but not by pregabalin. In the OX model, single administration of E-52862 reversed the hypersensitivity to cold stimuli similarly to 100 mg/kg of gabapentin. Interestingly, repeated E-52862 administration twice daily over 7 days did not induce pharmacodynamic tolerance but an increased antinociceptive effect in all three models. Additionally, as shown in the STZ and OX models, repeated daily treatment with E-52862 attenuated baseline pain behaviours, which supports a sustained modifying effect on underlying pain-generating mechanisms. These preclinical findings support a role for σ1R in neuropathic pain and extend the potential for the use of selective σ1R antagonists (e.g., E-52862) to the chronic treatment of cephalic and extra-cephalic neuropathic pain.
Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement
Authors: Xu Rui , Xia Hesheng , He Weifeng , Li Zhichao , Zhao Jian , Liu Bo , Wang Yuzhen , Lei Qiang , Kong Yi , Bai Yang , Yao Zhihui , Yan Rongshuai , Li Haisheng , Zhan Rixing , Yang Sisi , Luo Gaoxing , Wu Jun 
Published: April 2016

AbstractA desirable microenvironment is essential for wound healing, in which an ideal moisture content is one of the most important factors. The fundamental function and requirement for wound dressings is to keep the wound at an optimal moisture. Here, we prepared serial polyurethane (PU) membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies. It was found that the dressing with a WVTR of 2028.3 ± 237.8 g/m2·24 h was able to maintain an optimal moisture content for the proliferation and regular function of epidermal cells and fibroblasts in a three-dimensional culture model. Moreover, the dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model. Our finds may be helpful in the design of wound dressing for wound regeneration in the future.
Novel asymmetric representation method for solving the higher-order Ginzburg-Landau equation
Authors: Wong Pring , Pang Lihui , Wu Ye , Lei Ming , Liu Wenjun 
Published: April 2016

AbstractIn ultrafast optics, optical pulses are generated to be of shorter pulse duration, which has enormous significance to industrial applications and scientific research. The ultrashort pulse evolution in fiber lasers can be described by the higher-order Ginzburg-Landau (GL) equation. However, analytic soliton solutions for this equation have not been obtained by use of existing methods. In this paper, a novel method is proposed to deal with this equation. The analytic soliton solution is obtained for the first time and is proved to be stable against amplitude perturbations. Through the split-step Fourier method, the bright soliton solution is studied numerically. The analytic results here may extend the integrable methods and could be used to study soliton dynamics for some equations in other disciplines. It may also provide the other way to obtain two-soliton solutions for higher-order GL equations.
Three-Dimensional Carbon Allotropes Comprising Phenyl Rings and Acetylenic Chains in sp+sp2 Hybrid Networks
Authors: Wang Jian-Tao , Chen Changfeng , Li Han-Dong , Mizuseki Hiroshi , Kawazoe Yoshiyuki 
Published: April 2016

AbstractWe here identify by ab initio calculations a new type of three-dimensional (3D) carbon allotropes that consist of phenyl rings connected by linear acetylenic chains in sp+sp2 bonding networks. These structures are constructed by inserting acetylenic or diacetylenic bonds into an all sp2-hybridized rhombohedral polybenzene lattice, and the resulting 3D phenylacetylene and phenyldiacetylene nets comprise a 12-atom and 18-atom rhombohedral primitive unit cells in the "Equation missing" symmetry, which are characterized as the 3D chiral crystalline modification of 2D graphyne and graphdiyne, respectively. Simulated phonon spectra reveal that these structures are dynamically stable. Electronic band calculations indicate that phenylacetylene is metallic, while phenyldiacetylene is a semiconductor with an indirect band gap of 0.58 eV. The present results establish a new type of carbon phases and offer insights into their outstanding structural and electronic properties.
Evaluation of Back‐Calculated Size and Timing Estimates for Juvenile Chinook Salmon Using Otolith Structure and Chemistry
Authors: Claiborne Andrew M. , Campbell Lance A. 
Published: April 2016

AbstractOtolith chemistry is often used to reconstruct origin, life history, and migratory pathways in anadromous fishes. Although the accuracy and precision of back‐calculated size at a particular life history transition (such as when anadromous fish move from fresh to saline water) is often not estimated. We evaluated back‐calculated size and timing estimates based on otolith ratios of strontium to calcium (Sr:Ca) in Chinook Salmon Oncorhynchus tshawytscha marked with elevated concentrations of strontium chloride (SrCl). We used a combination of laser‐ablation, inductively coupled, plasma mass spectrometry (LA‐ICPMS), back‐calculation models, and daily increments to evaluate the accuracy of such estimates. Overall, back‐calculated size at marking was underestimated by <2 mm using direct and proportional back‐calculations of FL based on otolith Sr:Ca. Proportional back‐calculations of fish length were underestimated on average by 2.60 mm (SD, 2.09) when somatic growth (%/d) was less than otolith growth (%/d) and overestimated by an average of 4.89 mm (SD, 3.19) when somatic growth was greater than otolith growth. However, when somatic and otolith growth were equal, proportional back‐calculations were more accurate than direct estimates. Overall, the number of otolith daily increments since Sr:Ca inflection underestimated the actual days since marking by a median of 1 d (SD, 0.57) and was similar for individuals sampled 8–79 d after marking. Results from this study suggest that life history parameters for Chinook Salmon estimated using LA‐ICPMS, back‐calculation models, and daily increments are robust estimates suitable for ecological field studies.Received September 22, 2015; accepted December 29, 2015 Published online April 18, 2016
Amyloid-β plaque deposition measured using propagation-based X-ray phase contrast CT imaging
Authors: Astolfo Alberto , Lathuilière Aurélien , Laversenne Vanessa , Schneider Bernard , Stampanoni Marco 
Published: April 2016

Amyloid beta accumulation into insoluble plaques (Aβp) is known to play a significant role in the pathological process in Alzheimer's disease (AD). The presence of Aβp is also one of the neuropathological hallmarks for the disease. AD final diagnosis is generally acknowledged after the evaluation of Aβp deposition in the brain. Insoluble Aβp accumulation may also concur to cause AD as postulated in the so-calledamyloid hypothesis. Therefore, the visualization, evaluation and quantification of Aβp are nowadays the keys for a better understanding of the disease, which may point to a possible cure for AD in the near future. Synchrotron-based X-ray phase contrast (XPC) has been demonstrated as the only imaging method that can retrieve the Aβp signal with high spatial resolution (up to 10 µm), high sensitivity and three-dimensional information at the same time. Although at the moment XPC is suitable forex vivosamples only, it may develop into an alternative to positron emission tomography and magnetic resonance imaging in Aβp imaging. In this contribution the possibility of using synchrotron-based X-ray phase propagation computed tomography to visualize and measure Aβp on mouse brains is presented. A careful setup optimization for this application leads to a significant improvement of spatial resolution (∼1 µm), data acquisition speed (five times faster), X-ray dose (five times lower) and setup complexity, without a substantial loss in sensitivity when compared with the classic implementation of grating-based X-ray interferometry.
Voluntary traceability standards and the role of economic incentives
Authors: Stranieri Stefanella , Cavaliere Alessia , Banterle Alessandro 
Published: April 2016

Purpose
The proliferation of traceability standards shed light on the understanding of the mechanisms leading agri-food firms to choose among different kind of rules and systems for their implementation. The present paper investigates the role of firms economic incentives on the adoption of different traceability systems. In specific, the analysis aims at segmenting food firms on the basis of economic incentives for the adoption of voluntary traceability and the levels of the system complexity implemented.

Design/methodology/approach
A survey based on an ad hoc questionnaire was conducted in 2014 on a sample of firms certified ISO 22005/2008. Cluster analysis was run for the analysis and one-way ANOVA was used to confirm differences among clusters.

Findings
The analysis presents three different clusters in terms of economic incentives for voluntary traceability and the level of systems complexity implemented. All the clusters reveal that supply chain incentives play a key role. Moreover, ‘fine traceability’ clusters firms with high level of traceability. They consider food safety as an important incentive to adopt a voluntary standard. ‘Medium traceability’ groups firms with an average level of traceability system complexity. The interviewed consider the firm reputation as strategic driver for voluntary standard implementation. The cluster ‘coarse traceability’ groups firms which introduced traceability for quality differentiation of products on the market. These firms implemented a low level of traceability system complexity.

Research limitations/implications
The paper presents some limitations due to the sample dimension. Future research is oriented to test such results on an extended sample and to analyse the relationships between the traceability system implemented and the different kind of economic incentives for traceability standards.

Originality/value
The present paper offers two main contributions. From a conceptual point of view it tries to deepen existing knowledge on the mechanisms regulating the existence of different traceability standards. From a managerial point of view, the analysis contributes in the understanding of firm strategies in relation to the adoption of different traceability systems. Such results could address firm management on the allocation of financial resources for the adoption of different traceability systems.
Towards a grounded view of collaboration in Indian agri-food supply chains: a qualitative investigation
Authors: Aggarwal Shikha , Srivastava Manoj Kumar 
Published: April 2016

Purpose
The purpose of this paper is to understand the process and role of supply chain collaboration in Indian agri-food industry and highlight the perceptions of buyers and suppliers towards each other. The paper seeks to find out how can collaboration in agri-food supply chain lead to low wastage and better efficiency. Also, the paper attempts to capture the nuances of collaborative practices and perceptions of buyers and suppliers towards collaboration.

Design/methodology/approach
Case study methodology in a top Indian food-processing firm was conducted to explore the application and benefits of collaboration in supply chains. In-depth interviews with upstream supply chain members were conducted to understand the process of supply chain collaboration. Grounded Theory Methodology was used to analyze the transcripts.

Findings
Firstly, through content analysis of interview transcripts a comprehensive framework and a generic model was derived to understand the process of supply chain collaboration. Supplier selection, Joint Planning and Information sharing were found to be main antecedents while profits; waste reduction and supply chain efficiency were major outcomes of collaboration. Secondly, it was found that the suppliers are usually more skeptical of the buyers and don’t trust them easily. While, for buyers, it is very important to have good relations with suppliers and should make provide incentives to suppliers for collaboration.

Originality/value
To the best of our knowledge, this is the first study to elaborate the process and outcomes of collaborative activities along an Indian agri-food supply chain through in-depth qualitative study. In developing countries, agriculture industry is the backbone of economy. Therefore, the insights developed in this study may be useful for managers in agribusiness to dwell into such supply chain practices that would increase profit and efficiency, and decrease wastage.
Presence of enterobius vermicularis infections and food hygiene knowledge levels among catering industry personnel
Authors: Uçar Asli , Arısoy Munevver , Çakıroğlu Funda Pınar , Candar Sabri 
Published: April 2016

Purpose
This study was aimed to determine the presence of Enterobius vermicularis in workers in hospital kitchens in Ankara, Turkey and the levels of their food hygiene knowledge

Design/methodology/approach
The study included 270 employees of six catering companies that cater to hospitals in Ankara who agreed to participate in the study. Two-part questionnaires were used. The first part solicited demographic information, and the second part’s questions determined the workers’ personal hygiene knowledge. Samples taken from the participants to determine the presence of Enterobius vermicularis were collected using the cellophane application method.

Findings
The parasite was found in 78.1% of the personnel. The average hygiene knowledge scores were 58.94+18.1 on a 100-point scale. The changes introduced by the new "Food Hygiene Regulation" should be implemented without abolishing the food handler examination.

Originality/value
Food safety is an important issue that can affect lots of people. Food handlers are an important part for contamination of food. Because of this reason their hygiene knowledge and personal hygiene are very important. Because of high rate of Enterobius vermicularis the results show that they are not careful about their personal hygiene rules. So they can contaminate to food and can cause food-borne illnesses. The paper highlights the importance of education that affects food safety practices in food industry
Implementation of information literacy programmes in public libraries
Authors: Kingori George , Njiraine Dorothy , Maina Stephen 
Published: April 2016

Purpose
The purpose of this study is to examine the implementation of information literacy programmes in the public libraries in Kenya as demonstrated through a case study of the major public library in the country – Kenya National Library Service (KNLS).

Design/methodology/approach
The use of a case study research design made it possible to establish in-depth personal views, opinions and attitudes of the various respondents through face-to-face interviews and questionnaires. Both quantitative and qualitative approaches were used to collect data from the respondents. Purposive and random sampling techniques were used, and data were analyzed.

Findings
Major findings of this study indicated that the majority of users at the KNLS relied heavily on the print information materials, while some users, especially researchers, utilized the Internet for their academic work or research. The findings indicated that information literacy should be embedded in the information literacy programmes in all public libraries.

Research limitations/implications
The study was confined to the KNLS. A much wider scope could be untenable, necessitating such limitation.

Practical implications
As KNLS is the national library charged with the responsibility of providing public library services, it is a major player in terms of policies and guidelines. The study will encourage users in public libraries to appreciate the importance of information resources and also sensitize public library administrators to support information literacy programmes.

Social implications
The study will enable the educational administrators to develop and plan relevant instructional models related to information literacy, critical thinking and independent learning. The challenges and solutions experienced at the KNLS can be applied in other public libraries in Kenya.

Originality/value
The study identified the various gaps and challenges that exists in implementation of information literacy programmes in public libraries. Major recommendations of this study are: users should be provided with training on use of information resources; library staff should be provided with methodology skills to make them effective trainers; and public libraries should partner with other stakeholders to provide information literacy programmes. In addition, adequate funding for physical, material and human resources should be provided to facilitate the implementation of information literacy programmes in the public libraries in Kenya.
Embedded librarianship: questions and answers from librarians in the trenches
Authors: Kvenild Cassandra , Tumbleson Beth E. , Burke John J. , Calkins Kaijsa 
Published: April 2016

Purpose
This paper aims to share the current state of embedded librarianship in learning management systems as reported by academic librarians. The paper highlights the best practices, as well as continuing questions, in the field of embedded librarianship.

Design/methodology/approach
The authors collected participant feedback in two active, participatory panel discussions at national conferences. The open forums were centered on three guiding themes of embedded librarianship: building connections with faculty and students; utilizing technology tools; and providing information literacy and assessment. Participants answered directed questions, and their responses were recorded and analyzed for this paper.

Findings
Librarians report an increasing demand for library services in learning management systems. Collaboration and partnerships across campus are required for successful embedded librarian projects. Technology tools continue to evolve and change, and most librarians can anticipate using multiple learning management systems over time. There is an ongoing need for professional development in online library instruction and assessment.

Originality/value
This paper provides a snapshot of the current state of embedded librarianship in learning management systems. It offers insights about what academic librarians value, what they have learned and what concerns they still have about library instruction in online environments.
Characterization of Printing Inks Using DART‐Q‐TOF‐MS and Attenuated Total Reflectance (ATR) FTIR
Authors: Williamson Rhett , Raeva Anna , Almirall Jose R. 
Published: April 2016

AbstractThe rise in improved and widely accessible printing technology has resulted in an interest to develop rapid and minimally destructive chemical analytical techniques that can characterize printing inks for forensic document analysis. Chemical characterization of printing inks allows for both discrimination of inks originating from different sources and the association of inks originating from the same source. Direct analysis in real‐time mass spectrometry (DART‐MS) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR) were used in tandem to analyze four different classes of printing inks: inkjets, toners, offset, and intaglio. A total of 319 samples or ~ 80 samples from each class were analyzed directly on a paper substrate using the two methods. DART‐MS was found to characterize the semi‐volatile polymeric vehicle components, while ATR‐FTIR provided chemical information associated with the bulk components of these inks. Complimentary data results in improved discrimination when both techniques are used in succession resulting in >96% discrimination for all toners, 95% for all inkjets, >92% for all offset, and >54% for all intaglio inks.