bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early maladaptive schemas in adolescents with attention deficit hyperactivity disorder
Authors: Sireli Ozlem , Colak Mehmet , Demirci Tugce Hilda , Savascihabes Ayse Ece , Oz Cinar Hatice 
Published: October 2024

IntroductionCurrent evidence suggests that early maladaptive schemas are affected in attention deficit hyperactivity disorder (ADHD). Most of the studies on the subject have been conducted with adults, but the number of studies conducted with adolescents with ADHD is quite limited. The aim of this study was to evaluate early maladaptive schemas in adolescents diagnosed with ADHD.MethodsThe study included 66 patients diagnosed with ADHD and 70 healthy adolescents who were similar to the case group in terms of age and gender. Clinical evaluation of the case and control groups were performed with "The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5 November 2016-Turkish Adaptation (K-SADS-PL-DSM-5-T)". "Conners-Wells Adolescent Self-Report Scale - Revised Short Form (CASS-RS)" and "Set of Early Maladaptive Schema Questionnaires for Children and Adolescents between the ages of 10-16" were administered to all participants.ResultsIt was determined that the schema scores of "dependence/incompetence", "vulnerability to harm or illness", "entitlement/grandiosity", "insufficient self-control", "subjugation" were significantly higher in the ADHD group than in the control group. A negative, significant relationship was found between age and "enmeshment/undeveloped self", "entitlement/grandiosity" and "insufficient self-control" schema scores. There was no significant difference between schema scores in terms of gender in the ADHD group. Additionally, no significant relationship was found between the education level of the parents, family income levels and schema scores. A significant positive relationship was found between the CASS-RS scores and all schema scores. As a result of the regression analysis, it was determined that CASS-RS scores positively predicted all schema scores, while the age variable negatively predicted only the schema scores of "enmeshment/undeveloped self".DiscussionResults of this study showed that there were significant differences in adolescents in the ADHD group compared to the control group in terms of early maladaptive schemas, and that ADHD symptom levels was associated with early maladaptive schemas.
Spatiotemporal modeling of COVID-19 spread: unveiling socioeconomic disparities and patterns, across social classes in the urban population of Kermanshah, Iran
Authors: Zangeneh Alireza , Hamidipour Nasim , Khazir Zahra , Ziapour Arash , Molavi Homa , Kiaee Zeinab Gholami , Teimouri Raziyeh , Shakiba Ebrahim , Soofi Moslem , Khosravi Shadmani Fatemeh 
Published: October 2024

BackgroundPresenting ongoing outbreaks and the potential for their spread to nearby neighborhoods and social classes may offer a deeper understanding, enable a more efficient reaction to outbreaks, and enable a comprehensive understanding of intricate details for strategic response planning. Hence, this study explored the spatiotemporal spread of COVID-19 outbreaks and prioritization of the risk areas among social classes in the Kermanshah metropolis.MethodsIn this cross-sectional study, the data of 58.951 COVID-19-infected patients were analyzed. In 2020, out of 24.849 infected patients, 10.423 were females, 14,426 were males, and in 2021, 15.714 were females, and 18,388 were males. To categorize social classes (working, middle, and upper), we utilized economic, social, cultural, and physical indicators. Our analysis utilized Arc/GIS 10.6 software along with statistical tests, including standard distance (SD), mean center (MC), standard deviational ellipse (SDE), and Moran’s I.ResultsThe results revealed that the average epicenter of the disease shifted from the city center in 2020–2021 to the eastern part of the city in 2021. The results related to the SD of the disease showed that more than 70% of the patients were concentrated in this area of the city. The SD of COVID-19 in 2020 compared to 2021 also indicated an increased spread throughout the city. Moran’s I test and the hotspot test results showed the emergence of a clustered pattern of the disease. In the Kermanshah metropolis, 58,951 COVID-19 cases were recorded, with 55.76% males and 44.24% females. Social class distribution showed 28.86% upper class, 55.95% middle class, and 15.19% working class. A higher disease prevalence among both males and females in the upper class compared to others.DiscussionOur study designed a spatiotemporal disease spread model, specifically tailored for a densely populated urban area. This model allows for the observation of how COVID-19 propagates both spatially and temporally, offering a deeper understanding of outbreak dynamics in different neighborhoods and social classes of the city.
Application and interpretation of immunophenotyping data in safety and risk assessment
Authors: Johnson Victor J. , Luster Michael I. , Maier Andrew , Boles Corey , Miller Eric W. , Arrieta Daniel E. 
Published: October 2024

The use of immunophenotyping during immunotoxicity investigations was first popularized in the 1980 s and has since become more integrated into diagnostic and non-clinical assessments. The data provided from immunophenotyping can serve as an initial source of information to guide decisions for additional, more advanced, immunotoxicity testing as well as for human health safety and risk assessment of drugs and chemicals. However, comprehensive guidance describing applications of immunophenotyping data in immunotoxicity investigations is lacking, particularly among regulatory bodies. Therefore, a critical examination is needed for the appropriate interpretations and potential misinterpretations of such data during the assessment of drug safety and chemical risk. As such, the current uses and implications of immunophenotyping data in human health safety and risk assessments has been evaluated to provide additional context for the application of current methodologies and guidelines. In addition, case studies are presented to highlight the challenges of interpreting immunophenotyping results along with incorporating the findings into immunotoxicity investigations. Based on the analyses of current approaches and methodologies, a decision flow is presented for use of immunophenotyping data during risk informed decision making.
Dynamic contrast enhanced high field magnetic resonance imaging for canine primary intracranial neoplasia
Authors: Choi Simon , Brighi Caterina , Long Sam 
Published: October 2024

IntroductionDistinguishing meningiomas from other intracranial neoplasms is clinically relevant as the prognostic and therapeutic implications differ greatly and influence clinical decision making. Dynamic contrast-enhanced MRI (DCE-MRI) is an imaging technique that assists with characterisation of physiologic alterations such as blood flow and tissue vascular permeability. Quantitative pharmacokinetic analysis utilising DCE-MRI has not been studied in canine neuro-oncology.MethodsA retrospective study was performed in canine patients that underwent DCE-MRI with an imaging diagnosis of an intracranial meningioma and surgery for histopathological diagnosis. Kinetic parameters Ktrans and cerebral blood flow were measured and compared to assess whether differences could be identified between meningiomas and other intracranial neoplasms.ResultsSix dogs with meningiomas and 3 dogs with other intracranial neoplasms were included for statistical analysis. Cerebral blood flow values were found to be statistically higher within meningiomas compared to other intracranial neoplasms. Ktrans values were higher within meningiomas than in other types of intracranial tumours, however this difference did not reach statistical significance.DiscussionBased on the results of this study cerebral blood flow measurement can be utilised to differentiate canine intracranial meningiomas from other similar appearing intracranial tumours.
Increased freedom of head movement mitigates stress and bacterial load in the airways of horses during transport
Authors: Takahashi Yuji , Niwa Hidekazu , Ebisuda Yusaku , Mukai Kazutaka , Yoshida Toshinobu , Raidal Sharanne , Padalino Barbara , Ohmura Hajime 
Published: October 2024

IntroductionProtection of horse welfare during transport is crucial. The aim of this study was to determine the effect of head and neck restraint on behavior and airway bacteria.MethodsIn a randomized crossover study, six healthy Thoroughbreds were transported by road for 22 h in an individual bay with tight head restraint (50 cm short-rope) or loose head restraint (95 cm long-rope). Behavioral parameters relating to head position, eating, and stress were monitored during transportation. Tracheal wash samples were obtained 6 days before and immediately after transport for bacterial culture and metagenomic analysis.Results and discussionCompared to before transport, bacterial load (CFU/mL) after transport was significantly increased in the short-rope group (p = 0.04), whereas no changes were observed in the long-rope group. Transport significantly reduced Simpson index at phylum, class, order, and family levels in both groups (p &lt; 0.001) of tracheal microbiota. In both groups, this reduction was associated with increases in the dominant members of relative abundance at phylum (Firmicutes: +24% in long-rope and +14% in short-rope), class (Bacilli: +20% in long-rope and +22% in short-rope) and family (Streptococcaceae: +22% in long-rope and +23% in short-rope) levels. Licking behavior during transportation with short-rope restraint was more frequent than in horses with long-rope restraint. These results suggest loose head restraint during transportation is likely to ameliorate stress and mitigate the associated increased bacterial load in the lower airways associated with transport. Further, head position during transportation is likely a more important determinant of airway hygiene and distress than duration of travel.
G6PD Potenza: A Novel Pathogenic Variant Broadening the Mutational Landscape in the Italian Population
Authors: Ricciardi Tenore Claudio , Tulli Eugenia , Calò Claudia , Bertozzi Roberto , Evangelista Jessica , Maneri Giulia , Rinelli Martina , Brisighelli Francesca , Perrucci Alessia , De Paolis Elisa , Urbani Andrea , De Bonis Maria , Minucci Angelo 
Published: October 2024

Background: Glucose 6 phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the pentose phosphate pathway. The loss of G6PD activity in red blood cells increases the risk of acute haemolytic anaemia under oxidative stress induced by infections, some medications, or fava beans. More than 200 single missense mutations are known in the G6PD gene. A 41-year-old woman with a family history of favism coming from the Basilicata region (Italy) was evaluated at our hospital for G6PD abnormalities. Methods: DNA was extracted from a peripheral blood sample and genotyped for the most common G6PD pathogenic variants (PVs). Positive results obtained by Restriction Fragment Length Polymorphism (RFLP), as per practice in our laboratory, were then reconfirmed in Sanger sequencing. Results: RFLP analysis highlighted a variant compatible with the G6PD Cassano variant. Confirmatory testing by Sanger unexpectedly identified a novel variant: c.1357G>A, p.(Val453Met) (NM_001360016.2); the same variant was found in the patient’s mother. In silico models predicted a deleterious effect of this variant at the protein level. The novel G6PD variant was named “G6PD Potenza” on the basis of the patient’s regional origin. Conclusions: This case describes a novel G6PD variant. It also highlights how the Sanger sequencing technique still represents an indispensable confirmatory standard method for variants that could be misinterpreted by only using a “first-level” approach, such as the RFLP. We stress that the evaluation of clinical manifestations in G6PD-deficient patients is of primary importance for the classification of each new G6PD mutation, in agreement with the new WHO guidelines.
NGHIÊN CỨU THỰC THI CHÍNH SÁCH GIẢM NGHÈO DÂN TỘC THIỂU SỐ TẠI HUYỆN ĐỒNG VĂN, TỈNH HÀ GIANG GIAI ĐOẠN 2018 – 2022
Authors: Anh Vũ Vân , Giang Vi Thị , Mỹ Hà Thị Ngọc , Hướng Vy Thị , Nhung Nguyễn Thị Tuyết 
Published: October 2024

Nghiên cứu này nhằm đánh giá thực trạng việc thực thi các chính sách giảm nghèo dân tộc thiểu số tại huyện Đồng Văn, tỉnh Hà Giang; từ đó đề xuất một số giải pháp để nâng cao hiệu quả thực thi chính sách giảm nghèo. Bên cạnh việc thu thập số liệu thứ cấp từ các nguồn báo cáo khác nhau, nghiên cứu chủ yếu sử dụng phương pháp phân tích, so sánh và điều tra, khảo sát thực địa. Kết quả nghiên cứu cho thấy hiệu quả tích cực và tồn tại hạn chế trong thực thi chính sách thông qua đánh giá bốn nhóm chính sách (chính sách đào tạo nghề và giải quyết việc làm, chính sách hỗ trợ tạo điều kiện cho người nghèo tiếp cận với các dịch vụ cơ bản, chính sách tín dụng, chính sách hỗ trợ đặc thù). Giai đoạn 2018 – 2022, các chính sách giảm nghèo đem lại tác động tích cực đến cộng đồng dân tộc thiểu số huyện Đồng Văn trên nhiều lĩnh vực như nâng cao thu nhập, giải quyết việc làm, giảm tỷ lệ nghèo… Tuy nhiên, hiệu quả thực tế của các chính sách giảm nghèo vẫn chưa cao do chưa đồng bộ, chưa phù hợp đối tượng triển khai... Nghiên cứu này là cơ sở để các cấp chính quyền tham khảo, thực thi chính sách góp phần nâng cao hiệu quả chính sách giảm nghèo dân tộc thiểu số ở huyện Đồng Văn trong thời gian tới.
ĐẢNG BỘ HUYỆN BÌNH XUYÊN, TỈNH VĨNH PHÚC LÃNH ĐẠO PHÁT TRIỂN KINH TẾ CÔNG NGHIỆP (2015 - 2022)
Authors: Huyền Dương Thị , Nga Trương Thị Nguyệt 
Published: October 2024

Bình Xuyên được xác định là huyện trọng điểm phát triển công nghiệp của tỉnh Vĩnh Phúc với nhiều khu công nghiệp và cụm công nghiệp. Do đó, từ năm 2015 đến năm 2022, Đảng bộ, chính quyền huyện Bình Xuyên đã đề ra chủ trương và tích cực chỉ đạo đẩy mạnh phát triển kinh tế công nghiệp. Thông qua phương pháp lịch sử và phương pháp logic, bài viết làm rõ chủ trương của Đảng bộ và kết quả thực hiện phát triển kinh tế công nghiệp ở huyện Bình Xuyên. Kết quả nghiên cứu cho thấy quy mô nền kinh tế của huyện Bình Xuyên không ngừng tăng lên, giá trị sản xuất ngành công nghiệp chiếm tỷ trọng rất lớn, góp phần chuyển dịch cơ cấu kinh tế theo hướng hiện đại, tiến độ giải phóng mặt bằng được đẩy nhanh, cải cách thủ tục hành chính, cải thiện môi trường đầu tư được chú trọng nên thu hút được nhiều doanh nghiệp trong và ngoài nước. Bài viết góp phần cung cấp thêm luận chứng khoa học cho việc hoạch định chủ trương của địa phương trong phát triển công nghiệp ở giai đoạn tiếp theo.
ĐẢNG BỘ HUYỆN VĨNH TƯỜNG, TỈNH VĨNH PHÚC LÃNH ĐẠO XÂY DỰNG NÔNG THÔN MỚI NÂNG CAO (2020 - 2023)
Authors: Lê Nguyễn Thị 
Published: October 2024

Thực hiện Chương trình mục tiêu Quốc gia về xây dựng Nông thôn mới, đến năm 2023, trên địa bàn huyện Vĩnh Tường, tỉnh Vĩnh Phúc, 100% các xã đã đạt tiêu chí Nông thôn mới và đang tiếp tục đẩy mạnh thực hiện xây dựng nông thôn mới nâng cao, nông thôn mới kiểu mẫu. Sử dụng phương pháp lịch sử, phương pháp logic, phương pháp thống kê, phân tích, tổng hợp số liệu, bài viết tập trung làm sáng tỏ chủ trương xây dựng nông thôn mới nâng cao và nông thôn mới kiểu mẫu của Đảng bộ huyện Vĩnh Tường từ năm 2020 đến năm 2023. Chủ trương đúng và trúng đã góp phần đưa Vĩnh Tường trở thành huyện dẫn đầu của tỉnh Vĩnh Phúc về các tiêu chí của nông thôn mới kiểu mẫu và nông thôn mới nâng cao. Kết quả nghiên cứu góp phần vào việc tổng kết lịch sử, đúc kết kinh nghiệm cần thiết phục vụ cho công tác lãnh đạo, chỉ đạo xây dựng nông thôn mới ở địa phương hiện nay. Đồng thời, nghiên cứu cũng góp thêm luận cứ cho việc bổ sung, phát triển đường lối lãnh đạo sự nghiệp xây dựng nông thôn mới của Đảng Cộng sản Việt Nam trong thời kỳ đổi mới và hội nhập quốc tế.
Authors: Сиротина Анна Владимировна 
Published: October 2024

В статье на основе анализа архивных материалов и проектной документации рассматривается история формирования объектов культурного наследия музейного комплекса ≪Усадьба Костино≫, расположенного в городе Королеве, в одной из старейших усадеб Московской области рубежа XIX-XX веков. Впервые публикуются данные, касающиеся ремонтных и реставрационных работ по Мемориальному дому-музею В.И. Ленина - единственному в городе объекту культурного наследия (памятнику истории) федерального значения. Дается представление о результатах последних инженерных изысканий здания мемориального музея, проблемах и перспективах его научной реставрации
This is an article which based of analysis archival documents and project documentation considers history of formation of cultural heritage objects museum union ≪Costino’s Manor≫ located in Korolev city in one of the eldest manor of Moscow union of XIX-X centuries. This is the first time when repair and restoration data about the Memorial house-museum of Vladimir Lenin is published -the only one cultural heritage object (historical monument) of federal significance. The article gives performance about result of final engineering researching of the Memorial house-museum, problems and prospects of scientific restoration.
Authors: Бельская Светлана Андреевна 
Published: October 2024

В статье представлен обзор книжного собрания Болшевской трудовой коммуны, хранящегося в муниципальных учреждениях культуры г. Королёва. Книги рассматриваются как ценный информационный ресурс и уникальный источник, который можно использовать для различных историко-культурных исследований. Предложен план совместной работы библиотеки и музея по каталогизации собрания с целью включения его в реестр книжных памятников Российской Федерации.
The article presents an overview of the book collection of the Bolshevskaya labor commune, stored in the municipal cultural institutions of Korolev. Books are considered as a valuable information resource and a unique source that can be used for various historical and cultural studies. The plan of joint work of library and Museum on cataloguing of collection for the purpose of its inclusion in the register of book monuments of the Russian Federation is offered.
Authors: Крижевский Максим Владимирович 
Published: October 2024

Рассматривается проблема смешения и взаимной подмены в повседневном словоупотреблении понятий канон и стиль, что провоцирует деформации авторского и зрительского восприятия церковного искусства в целом.
Today, everyday use can be faced with confusion and even mutual substitution of these concepts. The intersection of canon and style creates a number of problems for the author's and the audience's consciousness, for church art in general
Authors: Журков Максим Сергеевич 
Published: October 2024

Рассматривая пересечения понятий игры и театра в межпредметном гуманитарном дискурсе, автор обосновывает методологическую продуктивность понятия социокультурного фронтира, позволяющего рассматривать феномен театра в его процессуальности. Границы театра подвижны в плане определения его как темпорального вида искусства в культурно-историческом и социальном аспектах. Но существуют и ценностно-смысловые пределы, за которыми он теряет свою сущность и социальную функцию.
Considering the intersection of the concepts of play and theater in the interdisciplinary humanitarian discourse, the author substantiates the methodological productivity of the concept of sociocultural frontier, which allows us to consider the phenomenon of theater in its procession. The boundaries of the theater are mobile in terms of defining it as a temporal form of art in the cultural, historical and social aspects. But there are value-semantic limits beyond which he loses his essence and social function.
Growth of water-insoluble rutile GeO2 thin films on (001) TiO2 substrates with graded Ge
x
Sn1−x
O2 buffer layers
Authors: Shimazoe Kazuki , Ogawa Temma , Nishinaka Hiroyuki 
Published: October 2024

Abstract
Rutile GeO2 (r-GeO2) is an ultrawide bandgap semiconductor with the potential for ambipolar doping and bulk single-crystal growth. In this study, we investigated r-GeO2 thin films grown on (001) TiO2 substrates with graded Ge
x
Sn1−x
O2 buffer layers. GeO2 grown on bare TiO2 substrates via mist chemical vapor deposition exhibited water-soluble amorphous and/or α-quartz phases alongside the rutile phase. In contrast, the insertion of graded Ge
x
Sn1−x
O2 buffer layers on the TiO2 substrate allowed the growth of single-phase water-insoluble r-GeO2 thin films. This study contributes to the development of water-insoluble r-GeO2 thin films for various applications.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL-AIR dan EKSTRAK ETIL ASETAT TERPURIFIKASI DAUN PECUT KUDA SECARA KLT AUTOGRAFI
Authors: Amin Asni , Waris Risda , Aminah Aminah , Fitri Nurul , Bunga A. Tenri 
Published: October 2024

Tanaman pecut kuda Stachytarpheta jamaeicensis termasuk tumbuhan berpotensi antikanker, antiinflamasi dan antioksidan. Tujuan penelitian adalah untuk membuktikan adanya aktivitas antioksidan ekstrak daun pecut kuda terhadap DPPH dengan metode KLT-autografi. Metode penelitian ini termasuk penelitian eksperimen laboratorium bersifat kualitatif terdiri dari ekstraksi sampel dengan etanol-air 70% secara maserasi, ekstrak kental dipurifikasi dan dibebas klorofil dan lemak, kemudian difraksinasi dengan etil asetat. Selanjutnya diidentifikasi kandungan kimia secara KLT menggunakan pereaksi spesifik : Dragendorf, Liberman-Buchard, Sitroborat, dan FeCl3.. Tahap terakhir dilakukan uji aktivitas antioksidan secara KLT autografi terhadap DPPH. Hasil penelitian: identifikasi kandungan kimia ekstrak secara KLT terbukti mengandung senyawa fenol, flavonoid, dan steroid/terpen. Hasil uji KLT antioksidan dengan DPPH terdapat 1 bercak berwarna kuning pada ekstrak etanol-air 70% (EEA-70%) dengan Rf=0,91 dan 2 bercak pada ekstrak etil asetat terpurifikasi (EEAT) dengan Rf= 0,75, dan Rf=0,54 yang dapat menghambat radikal bebas DPPH. Kesimpulan: Daun pecut kuda berpotensi digunakan sebagai bahan baku obat tradisional untuk antioksidan.
Uji Aktivitas Antibakteri Kombinasi Ekstrak Jahe Dan Ekstrak Lengkuas Merah Terhadap Bakteri Staphylococcus Aureus
Authors: Safutri Wina , Dwiningrum Riza , Pratiwi Mida , Mawarni Iga 
Published: October 2024

Peningkatan prevalensi global infeksi yang disebabkan oleh Staphylococcus aureus menekan masyarakat untuk menggunakan obat antibiotik. Penggunaan antibiotik dapat menyebabkan efek samping yang berbahaya oleh karena itu perlu adanya penggunaan obat alternatif alami. Penelitian ini bertujuan untuk melihat aktivitas kombinasi ekstrak jahe dan esktrak lengkuas merah sebagai obat alternatif alami dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini menggunakan metode eksperimen kuantitatif. Ekstrak kombinasi jahe dan lengkuas merah diperoleh dari metode maserasi menggunakan etanol 96%. Skrining fitokimia yang dilakukan yaitu uji flavonoid, terpenoid, tanin, dan saponin, sedangkan uji antibakteri terhadap Staphylococcus aureus dilakukan menggunakan metode difusi disk dengan variasi konsentrasi ekstrak kombinasi jahe dan lengkuas merah 80%:20%, 50%:50% dan 20%:80%. Hasil skrining fitokimia kedua esktrak positif mengandung flavonoid, terpenoid, tanin dan saponin. Adapun hasil zona hambat antibakteri secara berturut-turut yaitu 11,58±1,18mm, 4,46±0,70mm dan 2,95±0,45mm. Hasil uji statistik Kruskal Wallis didapatkan perbedaan rata – rata diameter zona hambat antar kelompok perlakuan dengan nilai (p 0,001). Selanjutnya pada uji Mann Whitney masing-masing konsentrasi memiliki perbedaan rata – rata zona hambat yang bermakna (p≤0,05) dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Kombinasi ekstrak jahe dan lengkuas memiliki aktivitas antibakteri dengan zona hambat tertinggi pada konsentrasi 80%:20% yang masuk kedalam katagori kuat.