bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of full disc Ca II K spectroheliograms
Authors: Chatzistergos Theodosios , Ermolli Ilaria , Solanki Sami K. , Krivova Natalie A. 
Published: September 2017

Context. Historical Ca II K spectroheliograms (SHG) are unique in representing long-term variations of the solar chromospheric magnetic field. They usually suffer from numerous problems and lack photometric calibration. Thus accurate processing of these data is required to get meaningful results from their analysis.
Aims. In this paper we aim at developing an automatic processing and photometric calibration method that provides precise and consistent results when applied to historical SHG.
Methods. The proposed method is based on the assumption that the centre-to-limb variation of the intensity in quiet Sun regions does not vary with time. We tested the accuracy of the proposed method on various sets of synthetic images that mimic problems encountered in historical observations. We also tested our approach on a large sample of images randomly extracted from seven different SHG archives.
Results. The tests carried out on the synthetic data show that the maximum relative errors of the method are generally <6.5%, while the average error is <1%, even if rather poor quality observations are considered. In the absence of strong artefacts the method returns images that differ from the ideal ones by <2% in any pixel. The method gives consistent values for both plage and network areas. We also show that our method returns consistent results for images from different SHG archives.
Conclusions. Our tests show that the proposed method is more accurate than other methods presented in the literature. Our method can also be applied to process images from photographic archives of solar observations at other wavelengths than Ca II K.
Extradural Dorsal Spinal Paraganglioma: A Rare Case Report and Literature Review
Authors: Bhaskar Mukesh , Kumar R. , Singh Sunil , Meel Mukta 
Published: September 2017

AbstractParagangliomas are neuroendocrine tumors originating from specialized cells of neural crest derivative. They are mostly found in the carotid and jugulotympanic region. Paragangliomas are extremely rare in the spine, and in literature, most cases are described as intradural extramedullary lesion in the cauda equine or filum terminale region. Extradural dorsal spine paragangliomas are even rarer, and till date, only 11 cases are reported in available literature. We describe a case of an adult woman who presented with mid dorsal region pain and sensory-motor spastic paraplegia. Imaging features were suggestive of D5 Pott's spine with epidural granulation tissue. Perioperatively, the tumor was moderately vascular and complete excision done. On HPE and IHC, diagnosis of paraganglioma was made. There was no evidence of clinical recurrence of the lesion at 6 months follow-up.
Divergent Axial Carpal Dislocation and Its Pathomechanics
Authors: García-Elias M. , Soto I. , López-Cervantes R. 
Published: September 2017

Background Axial carpal dislocations and fracture dislocations are 1.4 to 2.08% of all the fractures and dislocations of the wrist. These injuries are caused by high-energy blast or compression mechanisms. Only 11 cases of axial–radial–ulnar (ARU) fracture dislocations have been described in the literature.
Case Description We describe a case with a traumatic transtrapezoid, peritrapezium, transhamate, peripisiform ARU in a patient with acute compartment syndrome, traumatic transverse flexor retinaculum (TFR) rupture, and radial nerve palsy.
Literature Review The ARU fractures are injuries where the carpus is torn into three columns. ARU injuries have a high incidence of neurovascular, soft-tissue cover, and muscular-associated injuries. Depending on the injuries mentioned earlier, a bad functional prognosis can be expected. Nearly without exception, in ARU cases, a traumatic TFR rupture takes place. Garcia-Elias mentioned that the injury pattern is given by the speed, magnitude, and energy entry point.
Clinical Relevance We describe a case of an ARU injury which has not been previously described. In an analysis of the 12 ARU cases previously reported, we observed that when two or more applied forces converge, an ARU injury pattern can occur. That suggests that in ARU injuries, one side of the injury occurs before the other. Due to the extensive carpal damage, in patients with ARU, a restricted range of motion is more likely to happen than residual instability. Thus, in all these cases, an early mobilization and intensive rehabilitation is highly necessary.
Alarmierender Pregabalin-Missbrauch: Prävalenz im Münchener Raum, Konsummuster und Komplikationen
Authors: Zellner Nicolas , Eyer Florian , Zellner Tobias 
Published: September 2017

Zusammenfassung
Hintergrund Pregabalin ist u. a. zur Behandlung von neuropathischen Schmerzen und Angststörungen zugelassen. Inzwischen zeigt sich, dass es ein Missbrauchs- und Abhängigkeitspotenzial aufweist.
Methoden Es wurde eine Datenbankanalyse mit dem Suchbegriff „Pregabalin“ für alle von 2008 – 2015 in unserer Abteilung behandelten Patienten und im Giftnotruf München eingegangenen Anrufe durchgeführt. Von Oktober 2013 bis September 2014 wurden alle Patienten in eine Kohortenstudie eingeschlossen, die aufgrund einer Drogen-Intoxikation behandelt wurden oder sich zum Entzug (außer Ethanol) vorstellten.
Ergebnisse Von 2008 – 2015 wurden 263 Patienten mit Pregabalin-Missbrauch behandelt. Die Anzahl der Fälle pro Jahr stieg von 0 – 5 in den Jahren 2008 – 2011 auf 105 im Jahr 2015. 2008 gingen 3 Anrufe zu Pregabalin-Missbrauch im Giftnotruf ein, 2015 waren es 71.Von 2013 – 2014 hatten 80 von 370 Patienten Pregabalin konsumiert. Es war die fünftmeiste konsumierte Substanz. Pregabalin-Konsumenten hatten mehr zusätzliche Substanzen als andere Patienten konsumiert (Median 4 1
2
3
4
5
6 vs. 2 1
2
3
4
5
6, p < 0,001) und waren häufiger substituiert (41,2 vs. 21,7 %, p < 0,001). Die häufigsten ko-konsumierten Substanzen waren Benzodiazepine (66,3 %), Methadon (48,8 %), Buprenorphin (32,5 %) und Heroin (22,5 %). 88,0 % der intoxikierten Patienten hatten mittelgradig bis schwere Vergiftungssymptome wie Bewusstseinsminderungen (74,0 %), Atemnot (40,0 %), Agitation/Aggression (28,0 %), Unruhe (14,0 %), Halluzinationen (8,0 %) oder Krampfanfälle (8,0 %).Der semiquantitative Urinspiegel lag bei Intoxikationspatienten bei 51,4 ± 66,0 mg/g Kreatinin, bei Entgiftungspatienten bei 26,1 ± 23,0 (n = 58; p = 0,034).
Diskussion Der Missbrauch von Pregabalin steigt kontinuierlich an und stellt ein relevantes medizinisches Problem dar. Besonders suchterkrankte Patienten sind gefährdet. Ärzte sollten sich dem erheblichen Abhängigkeits- und Missbrauchspotenzial von Pregabalin bewusst sein sowie die Gefahren einer Intoxikation kennen.
Zentraler aortaler Blutdruck: Bedeutender Parameter für Diagnostik und Therapie
Authors: Middeke Martin 
Published: September 2017

AbstractIn recent years great emphasis has been placed on the role of central aortic blood pressure as measured non invasively using pulse wave analysis in pathophysiology of cardiovascular diseases and clinical aspects of hypertension. The difference of blood pressure between the central aorta and the brachial artery (amplification) is not constant but varies according to physiological, pathological and pharmacological mechanisms. Central aortic blood pressure is more strongly related to cardiovascular organ damages than does brachial pressure. Several antihypertensive drugs have different effects on aortic blood pressure as compared with brachial pressure. Central aortic blood pressure emerges superior to brachial pressure as target blood pressure in antihypertensive treatment.
Das Adenokarzinom des Ösophagus – Bestandsaufnahme einer drastisch zunehmenden Erkrankung
Authors: Hoeppner Jens , Glatz Torben , Claus Rainer , Fischer Andreas , Kraywinkel Klaus , Brunner Thomas 
Published: September 2017

ZusammenfassungDas Adenokarzinom des Ösophagus ist eine der am stärksten zunehmenden Tumorentitäten in der westlichen Welt. Seine Inzidenz hat sich seit 1991 in Deutschland mehr als versiebenfacht. Die bedeutendsten Risikofaktoren stellen die gastroösophageale Refluxerkrankung und die Adipositas dar. Die endoskopische Resektion ist ein effektives Verfahren für die Diagnostik und die kurative Therapie der Frühkarzinome. Die Ösophagusresektion ist die zentrale kurative Therapiemodalität für mucosa-überschreitende und nicht-metastasierte Tumorstadien. Neoadjuvante radiochemotherapeutische und perioperativ chemotherapeutische Behandlungsprotokolle kommen zunehmend zum Einsatz. Die onkologische Prognose für lokal fortgeschrittene Tumorstadien konnte auf 5- Jahresüberlebensraten von 50 % verbessert werden.
Acceptability of two colorectal cancer screening tests: pain as a key determinant in sigmoidoscopy
Authors: Kirkøen Benedicte , Berstad Paula , Botteri Edoardo , Dalén Eirin , Nilsen Jens , Hoff Geir , de Lange Thomas , Bernklev Tomm 
Published: September 2017

Abstract
Background Participants’ experience with a screening test can influence adherence, and therefore the efficacy of screening programs. We compared screening with unsedated flexible sigmoidoscopy and fecal immunochemical testing (FIT) for participants’ satisfaction with the decision and for willingness to repeat colorectal cancer screening.
Methods In a prospective, randomized trial 3257 individuals (50 – 74 years) were invited to either flexible sigmoidoscopy or FIT (1:1), of whom 1650 took up the offer (52.6 %). In total, 1497 screening participants completed at least one questionnaire, either before screening, and/or at three time points in the following year, that measured willingness to repeat screening, willingness to recommend screening, and satisfaction with decision to attend. There were 769 and 728 responders in the flexible sigmoidoscopy and FIT group, respectively. Additionally, 581 flexible sigmoidoscopy participants also completed a pain questionnaire.
Results 1 year later, 10 % of the flexible sigmoidoscopy participants were not willing to repeat screening, compared to 5 % of FIT participants. A higher percentage of women compared to men would not repeat flexible sigmoidoscopy screening (adjusted odds ratio [OR] 2.52, 95 % confidence interval [95 %CI] 1.48 to 4.28). Notably, 22 % of women reported pain during flexible sigmoidoscopy compared to 5 % of men. When we added pain to the statistical model, pain was significantly associated with unwillingness to repeat flexible sigmoidoscopy (OR 3.15, 95 %CI 1.68 to 5.87), while gender was no longer associated (OR 1.53, 95 %CI 0.82 to 2.88).
Conclusion Acceptability for flexible sigmoidoscopy and for FIT was high among Norwegian screening participants, though FIT participants were more willing to repeat screening. Women were less willing to repeat screening with flexible sigmoidoscopy compared to men. This gender difference seemed partly due to pain, and therefore preventable.This study is registered at ClinicalTrials.gov: NCT01538550.
Lautheitsoptimierte Messung von Summenaktionspotentialen
bei Cochlea Implantat Trägern
Authors: Berger Klaus , Hocke Thomas , Hessel Horst 
Published: September 2017

Zusammenfassung
Hintergrund Die postoperative Messung von Summenaktionspotentialen ist
aufgrund mangelnder Akzeptanz durch die CI-Träger nicht immer möglich. In dieser
Arbeit wurde untersucht, ob durch veränderte Messparameter eine höhere Akzeptanz
der Messung erreicht werden kann.
Methodik Es wurden Summenaktionspotentiale an 16 CI-Trägern bei
verschiedenen Pulsbreiten gemessen. An der Potentialschwelle wurde eine
Lautheitsbewertung der bei der Messung verwendeten Sequenzen durchgeführt.
Ergebnisse Die Registrierung der Summenaktionspotentiale wird bei höheren
Pulsbreiten von den CI-Trägern leiser empfunden.
Schlussfolgerung Bei mit höheren Pulsbreiten gemessenen
Summenaktionspotentialen findet sich ein zunehmender Abstand zwischen maximal
akzeptierter Stimulusintensität und Potentialschwelle. Dieser trägt zur höheren
Akzeptanz postoperativer Messungen bei.
Icaritin Improves Antibody-Induced Thrombocytopenia in a Mouse Model by Regulating T-cell Polarization
Authors: Sun Chenghong , Yang Jian , Wang Mingzhi , Pan Lihong , Yao Jingchun , Wang Shenglan , Guo Na , Li Chunyan , Zhang Guimin 
Published: September 2017

AbstractPrevious studies have shown that icaritin (ICT) has significant protective effects on immune thrombocytopenia (ITP), and the present study aimed to discuss the mechanism of this protective effect from the aspect of regulating T-cell polarization by an antibody-induced ITP mice model. Mice were given rat anti-mouse CD41 antibody (MWReg30) by intraperitoneal injection for 7 d to produce ITP model. At the same time, ICT was administrated at 10 mg/kg/d orally for 9 d. Peripheral blood platelets were counted by hematology analyzer. Spleen index was also tested. Spleen T-helper cell (Th), cytotoxic T-cell (CTL), Th1, Th2, Th17, regulatory T-cell (Treg), and follicular helper T-cell (Tfh) were quantified by flow cytometry. Serum Th1/Th2/Th17 cytokines were tested by mouse Th1/Th2/Th17 cytometric bead array (CBA) kit and transforming growth factor beta (TGF-β) were analyzed by enzyme-linked immunosorbent assay (ELISA) kit. The results indicated that ICT (10 mg/kg) protected against MWReg30-induced ITP, as evidenced by increased blood platelets and decreased spleen index. In addition, the imbalance of Th/CTL in ITP mice spleen was regulated by ICT. Meanwhile, ICT inhibited Th1, Th17, and Tfh and improved Th2 and Treg in ITP mice spleen. Furthermore, the results of CBA and ELISA suggested that ICT decreased serum Th1- and Th17-related cytokines and increased Th2 cytokines, as well as promoted the release of TGF-β. These results demonstrated that the protective effect of ICT on ITP was mediated by regulating T-cell polarization.
The meaning of a destination experience in Zhouzhuang, China.
Authors: Gao LiHua Gao LiHua 
Published: September 2017

Abstract

The research presented in this chapter identifies the specific attributes perceived by tourists in a destination and examinees how the attributes combine together to create a holistic destination experience for tourists. Empirical evidence was collected from 63 qualitative in-depth, in-destination interviews with tourists who were asked to discuss the memorable attributes of Zhouzhuang, a Chinese water town. The attributes identified through content analysis of the transcribed interviews were classified. In doing so, a new attribute type called 'service' was identified besides three other known attribute types (atmosphere, interaction, and memorabilia). Analysis of the coded transcripts indicates that there are associations among attributes (especially the four attribute types) in the minds of tourists, and that these form themes that can be essential for planning and marketing consumer experiences.
Perceptions of the Trinidad carnival experience from international travel bloggers.
Authors: Holder A. , Scott N. 
Published: September 2017

Abstract

This chapter presents a case study of the Trinidad and Tobago carnival experience and focuses on international travel bloggers' perceptions of the carnival. This study epitomizes a wide array of sensory and affective dimensions of the carnival experience. Of greater significance, the analysis of blogs and their authors' personal accounts revealed that this platform serves as a useful tool to appeal to one's senses and inner feelings, a characteristic that experience-based destination marketers may find valuable.
Dietary Euphorbia hirta Extract Improved the Resistance of Sharptooth Catfish Clarias gariepinus to Aeromonas hydrophila
Authors: Sheikhlar Atefeh , Meng Goh Yong , Alimon Razak , Romano Nicholas , Ebrahimi Mahdi 
Published: September 2017

Abstract
Aqueous and methanol extracts of lemon Citrus limon peel, Euphorbia hirta (aerial parts), and fenugreek Trigonella foenum-graecum seeds were tested for their in vitro antimicrobial activities against the bacterium Aeromonas hydrophila. A swab paper disk method showed that the methanol extract of E. hirta (EHE) had the largest inhibition zone and the lowest minimal inhibitory concentration compared to all other herbal extracts. Based on these results, EHE was included in the diets of Sharptooth Catfish Clarias gariepinus at 0 (control), 2, 5, or 7 g/kg of diet (experiment 1). Each treatment was conducted in triplicate, with 30 fish (mean weight ± SE = 9.4 ± 0.4 g) in each replicate. After 30 d, the growth, feed intake, hepatosomatic index (HSI), and plasma biochemical parameters were measured. With a separate batch of Sharptooth Catfish, the efficacy of the EHE diets in conferring fish resistance to A. hydrophila over 30 d was compared to that of a diet containing oxytetracycline (OTC; experiment 2). Six treatments were conducted in triplicate groups of 30 fish (mean weight ± SE = 9.0 ± 0.3 g); the Control fish were fed the control diet and were not injected with A. hydrophila, while the Control-AH and OTC-AH groups were infected with A. hydrophila and were fed either the control diet or the diet containing OTC at 1 g/199 g. The other three treatments included fish that were injected with A. hydrophila but fed diets with increasing EHE at 2, 5, or 7 g/kg. Experiment 1 showed no change to growth, feeding efficiency, HSI, or plasma biochemical parameters. In experiment 2, however, fish that were fed dietary EHE at 5 g/kg had significantly lower mortality than the Control-AH group, with further resistance observed for fish fed EHE at 7 g/kg. Dietary OTC was more effective than EHE as a prophylactic to A. hydrophila infection in Sharptooth Catfish. Nevertheless, EHE can potentially be a valuable dietary supplement to improve the resistance of Sharptooth Catfish to A. hydrophila infection.
Received May 3, 2017; accepted August 24, 2017 Published online October 31, 2017
Flavonoid compounds related to seed coat color of wheat
Authors: Kohyama Noriko , Chono Makiko , Nakagawa Hiroyuki , Matsuo Yosuke , Ono Hiroshi , Matsunaka Hitoshi 
Published: September 2017

AbstractIn red wheat, reddish-brown pigments accumulate in testa of mature seeds. Half-cut wheat seeds were immersed in p-dimethylaminocinnamaldehyde (DMACA) reagent that stains flavanol structures blue. Testa of 10–40 days after flowering (DAF) in red wheat (“Norin 61” and “Satonosora”) seeds were stained blue and the reagent color changed to blue with 10–25 DAF seeds. No blue staining was observed in white wheat (“Tamaizumi”) seeds during maturation. “Norin 61” seed coats at 10 DAF contained dihydroquercetin, dihydromyricetin, (+)-catechin, procyanidin B3, and prodelphinidin B3, which were identified by HPLC-diode array detector and LC-MS/MS analyses. These five components began accumulating 7 DAF, reached maxima at 10 or 15 DAF, and then decreased in red wheat seeds, but were not detected in white wheat seeds. These results suggest that flavanol and proanthocyanidins are possible precursors of the reddish-brown pigments of red wheat seeds, and are converted to insoluble compounds as the seeds mature.
TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation
Authors: Nakamura Minako , Kumrungsee Thanutchaporn , Sakuma Tetsushi , Yamamoto Takashi , Yanaka Noriyuki 
Published: September 2017

Abstract
In this study, we investigated the physiological function of glycerophosphodiesterase 5 (GDE5) in the proliferation of NIH3T3 fibroblasts. We used transcription activator-like effector nuclease (TALEN) in NIH3T3 cells with an intron targeting-mediated GDE5 gene knockout. The heterozygously GDE5-targeted NIH3T3 fibroblasts were isolated and showed decreased cell proliferation and up-regulation of EGFR mRNA expression, indicating that GDE5 modulates fibroblastic cell proliferation.
Feature Extraction from Sensor Data Streams for Optimizing Grinding Condition
Authors: Kondo Y , Higashimoto Y , Sakamoto S , Fujita T , Yamaguchi K 
Published: September 2017

Abstract
A visualization method for time-series sensing data was designed to optimize grinding condition. The fluctuation pattern of time-series data streams can be visualized as a white and black pattern by utilizing the spindle power change rate average. The designed visualization method was applied to a condition monitoring in lapping operation. The relation between the fallout abrasive grain content and lapping behaviour was experimentally examined. In the lapping with grinding fluid containing no fallout abrasive, the spindle power decreased in a monotone manner with lapping time, while in the lapping with fallout abrasive, the spindle power decreased with lapping time up to 20s of lapping and then tended to converge on a constant value. The spindle power change rate average displayed as a white and black pattern reproduced the changes of spindle power very well. The appearance probability of white or black pattern has a strong relation with the fallout abrasive content and the designed data processing scheme could make possible to predict the grinding fluid condition from the easy-handling grinding test.
In silico structural modeling of multiple epigenetic marks on DNA
Authors: Krawczyk Konrad , Demharter Samuel , Knapp Bernhard , Deane Charlotte M , Minary Peter 
Published: September 2017

Abstract
There are four known epigenetic cytosine modifications in mammals: methylation (5mC), hydroxymethylation (5hmC), formylation (5fC) and carboxylation (5caC). The biological effects of 5mC are well understood but the roles of the remaining modifications remain elusive. Experimental and computational studies suggest that a single epigenetic mark has little structural effect but six of them can radically change the structure of DNA to a new form, F-DNA. Investigating the collective effect of multiple epigenetic marks requires the ability to interrogate all possible combinations of epigenetic states (e.g. methylated/non-methylated) along a stretch of DNA. Experiments on such complex systems are only feasible on small, isolated examples and there currently exist no systematic computational solutions to this problem. We address this issue by extending the use of Natural Move Monte Carlo to simulate the conformations of epigenetic marks. We validate our protocol by reproducing in silico experimental observations from two recently published high-resolution crystal structures that contain epigenetic marks 5hmC and 5fC. We further demonstrate that our protocol correctly finds either the F-DNA or the B-DNA states more energetically favorable depending on the configuration of the epigenetic marks. We hope that the computational efficiency and ease of use of this novel simulation framework would form the basis for future protocols and facilitate our ability to rapidly interrogate diverse epigenetic systems.

Availability and implementation
The code together with examples and tutorials are available from http://www.cs.ox.ac.uk/mosaics

Supplementary information
Supplementary data are available at Bioinformatics online.