bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Pancreatitis in the Context of Hypercalcemia: Unveiling Multiple Myeloma
Authors: HK Jayasooriya , PGCS Bowatte , NPNB Pathirana 
Published: September 2024

Abstract

Background
Acute pancreatitis (AP) is an inflammatory condition of the pancreas, commonly triggered by gallstones or alcohol consumption. Hypercalcemia, although rare, is a recognized cause of AP, accounting for 1.5% to 8% of cases, typically due to primary hyperparathyroidism. Multiple myeloma (MM), a hematological malignancy characterized by clonal plasma cell proliferation, is an uncommon source of hypercalcemia and an even rarer cause of AP. While MM generally presents with anemia, bone pain, and renal impairment, hypercalcemia-induced AP as an initial manifestation is highly unusual and poses diagnostic challenges with meticulous clinical judgement.
Case Presentation
A 62-year-old male presented with severe epigastric pain radiating to the back, accompanied by nausea and vomiting. Laboratory tests revealed anemia, renal impairment, and elevated serum calcium levels. Imaging confirmed AP, while common causes like gallstones were excluded. Despite normal parathyroid hormone levels and no obvious bone metastases, an elevated erythrocyte sedimentation rate (ESR) raised suspicion for a hematological malignancy. Initial investigations, including serum protein electrophoresis and urine testing for Bence Jones protein, were inconclusive. However, a bone marrow biopsy confirmed the diagnosis of MM as the underlying cause of hypercalcemia-induced AP.
Conclusion
This case underscores the diagnostic complexity of hypercalcemia-induced AP, particularly when it is secondary to an uncommon cause like MM. Clinicians should consider MM in patients with unexplained hypercalcemia, even when initial tests are inconclusive, to avoid delays in diagnosis and treatment, which are crucial for improving patient outcomes.
Antimicrobial activity and phytochemical screening of ethanol extracts of six traditionally used medicinal plants in East Amhara, Ethiopia
Authors: Girmay Birhan , Mohammed Toyba , Getachew Aweku , Yeshanew Solomon , Habtamu Asmamaw , Agumas  
Published: September 2024

Abstract

Background: Antimicrobial resistance (AMR) poses a significant challenge to global health, necessitating the exploration of alternative treatments, particularly from natural sources. This study thus aimed to evaluate the antimicrobial activity and phytochemical profiles of six traditional medicinal plants from East Amhara in Ethiopia against Staphylococcus aureus and Salmonella typhi.
Methods: Ethanol crude extracts of Myrtus communis, Ziziphus spina-christi, Euclea racemosa, Syzygium guineense, Carissa spinarum, and Senna singueanawere prepared using a 1:10 (w/v) ratio cold maceration extraction technique. Antibacterial activity was assessed via the agar disk diffusion assay method, whereas Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were carried out by broth dilution method. Furthermore, phytochemical screenings of the extracts were conducted to identify secondary metabolites according to the respective protocols and operational manuals.
Results: The findings indicated a dose-dependent antibacterial effect across all the tested plant species. M. communis exhibited the strongest antibacterial activity against S. aureus (22.33±1.2 mm inhibition zone) followed by C. spinarum (18.61± 0.33 mm). Regarding the antibacterial effects against S. typhi, M. communis, and C. spinarumagain produced the first and second highest activity; 17.01±0.58 mm and 16.62±0.33 mm zone of inhibition respectively. The lowest antibacterial activity against S. aureus was recorded by the extract of S. singueana (14.61±0.33 mm), whereas, the extract of E. racemosa (13.30±0.33 mm) produced the weakest activity against S. typhi. The lowest MIC values (6.25 mg/ml) were also noted for M. communisagainst both bacterial strains, indicating potent antibacterial properties. Furthermore, phytochemical screening revealed the presence of multiple bioactive compounds, such as alkaloids, flavonoids, tannins, phenolics, terpenoids, saponins, steroids, glycosides, and anthraquinones among the tested extracts.
Conclusion: The study validates the antimicrobial potential of the selected medicinal plants, supported by their diverse phytochemical profiles. M. communis and C. spinarumwere found to cause potent antibacterial activity. The present study thus suggests that extracts of the leaves of these plant species may serve as valuable sources for developing new antimicrobial agents. Further investigation into their active compounds is also warranted to enhance therapeutic applications.
Computational Evaluation of ADMET Properties and Molecular Docking Studies on Cryptolepine Analogs as Inhibitors of HIV Integrase
Authors: Gupta Rajeev , Raza Amir , Singh Shivam Kumar , Kaur Jasmeen , Wadhwa Pankaj 
Published: September 2024

Background:
HIV/AIDS remains a global health challenge, demanding innovative antiretroviral
strategies. HIV integrase inhibition, a promising therapeutic target, warrants exploration.
This study investigates the potential of Cryptolepine and analogues as integrase inhibitors
through in-silico docking and ADMET profiles. Docking simulations reveal binding affinities,
guiding rational drug design. ADMET predictions assess the pharmacokinetics, ensuring clinical
viability. Cryptolepine and analogues show promise, offering a pathway for therapeutic development
against HIV/AIDS. Further, insights contribute to ongoing efforts in combating the pandemic
with effective antiretroviral strategies.

Methods:
Molecular docking investigations utilized Molegro Virtual Docker [MVD] 6.0, with the
target protein [PDB ID: 1QS4] obtained from the Protein Data Bank. Ligands, particularly Cryptolepine-
based, were selected from PubChem with adherence to Lipinski's Rule of Five for druglike
properties. Computational tools, including pkCSM, aided ADMET profiling. This study, conducted
on an AMD Ryzen 3 3200U computer with Windows 10 home, enhances understanding
and potential therapeutic strategies against HIV/AIDS.

Results:
From a virtual screening of the PubChem database, the top ten candidates were selected
based on their MolDock scores against the target 1QS4. All compounds had MolDock scores
greater than -70.00 kcal, with [01] RPA 1 exhibiting the highest MolDock Score [-83.85 kcal] and
Rerank Score [-39.59 kcal]. These compounds possessed the essential pharmacophore for HIV
integrase inhibition against 1QS4. However, three compounds, including [01] RPA 1, [00] RPA
1_6, and [04] RPA 1_1, showed no hydrogen bonding interactions with Val 79 and Val 150 amino
acid residues. This highlights the importance of structural analysis in understanding ligand-receptor
interactions for rational drug design against HIV integrase.

Conclusion:
This study investigates how Cryptolepine analogues inhibit HIV integrase via docking
and ADMET analysis. All analogues exhibit strong binding, especially those within the 400-
500 Da range. Specific amino acids and hydrogen bonds influence interactions. Compound [01]
RPA 1_3 shows high intestinal absorption and promising properties, making it a potential HIV
integrase inhibitor. The study highlights the importance of a comprehensive ADMET profile in
drug development and suggests further exploration of [01] RPA 1_3 for HIV/AIDS therapy.
Mental Health of Healthcare Workers during COVID-19 Pandemic: Systematic Review and Meta-analysis
Authors: Alzghoul Bashar I. 
Published: September 2024

Introduction
Outbreaks of infectious diseases, such as COVID-19, can lead to psychological distress and symptoms of mental illness, especially among healthcare workers (HCWs) who are at high risk of contracting the infection. This current crisis, in particular, adversely affects mental health due to the rapid spread of the infection from person to person and the uncertainty underlying the treatment guidelines, preventative measures, and the expected duration of its prevalence, which could affect the psychological, emotional, and behavioral symptoms. The purpose of this systematic review and meta-analysis was to identify, evaluate, summarize and analyze the findings of all relevant individual studies conducted to assess mental health symptoms during the COVID-19 pandemic. Furthermore, it aimed to identify any gaps in the literature, which could identify the potential for future research.

Methods
This PRISMA systematic review and meta-analysis on SCOPUS, Web of Science, Google Scholar, PubMed, and Science Direct stated from 11th Feb, 2021 to 11th March, 2022. Following the search to identify relevant literature, one author in the article evaluated the studies in relation to the inclusion and exclusion criteria. The systematic review included 31 studies, the meta-analysis of anxiety prevalence analyzed 20 studies and the meta-analysis of severe anxiety prevalence assessed 13 studies.

Results
As per the results that were obtained, for HCW, the most prevalent mental health symptoms were sleep disturbance, depression and anxiety, with a prevalence level of 42.9%, 77.6% and 86.5%, respectively. As per the pooled analysis, anxiety prevalence was recorded as 49% (95%CI, 0.36- 0.62), while for severe anxiety, the number dropped to 8% (95%CI, 0.05–0.10). The highest pooled prevalence of anxiety was observed in Turkey at 60% (95%CI, 0.51- 0.70). Alternatively, the lowest pooled prevalence was observed in China, 36% (95%CI, 0.23–0.50) and India, 36% (95%CI, 0.13–0.62). Based on the review of the relevant articles, a few methodological gaps were identified (i.e., Population of the studies and countries).

Conclusion
This study’s review and meta-analysis provide relevant information pertaining to the mental health status of healthcare workers across the world in light of the COVID-19 pandemic. They experience and endure high levels of mental health symptoms, and thus, it is necessary to provide them with mental and psychological support in this context.
Characteristics of and Factors Associated With Partner Service Uptake Cascade Among People With Newly Reported HIV/AIDS Diagnoses in Southeastern China in 2022: Cross-Sectional Survey
Authors: Jiang Jun , Chen Lin , Cheng Wei , Chen Wanjun , Yang Jiezhe , Xu Yun , Zhou Xin , Pan Xiaohong , Chai Chengliang 
Published: September 2024

Background
HIV notification and testing integrated into partner service (PS) practices among HIV-positive individuals have been proven to be an efficient approach for case finding, although it remains a weak link in China. Although nonmarital sexual activities accounted for a large proportion of newly diagnosed HIV-positive cases in China, little is known about PS uptake and associated factors within nonmarital partnerships.

Objective
This study aimed to describe HIV PS utilization and its associated factors among HIV-positive individuals with nonmarital sexual partners.

Methods
We recruited newly diagnosed HIV-positive individuals who had nonmarital sexual partners in 2022 in Zhejiang Province and offered them PS. We described the PS uptake cascade within sexual partner categories and analyzed the associated factors with 3 primary outcomes from the participants’ perspective: nonmarital partner enumeration, HIV testing, and HIV positivity.

Results
In this study, 3509 HIV-positive individuals were recruited as participants, and they enumerated 2507 nonmarital sex partners (2507/14,556, 17.2% of all nonmarital sex partners) with contact information. Among these, 43.1% (1090/2507) underwent an HIV test, with an HIV-positive rate of 28.3% (309/1090). Heterosexual commercial partners were the least likely of being enumerated (441/4292, 10.3%) and had the highest HIV-positive rate (40/107, 37.4%). At the participant level, 48.1% (1688/3509) of the participants enumerated at least one nonmarital sex partner with contact information, 52.7% (890/1688) had a sex partner tested for HIV, and 31% (276/890) had at least one nonmarital sex partner who tested positive. Multivariate analysis indicated that gender and transmission route were associated with both nonmarital sex partner enumeration and HIV testing. Age and occupation were associated with nonmarital sex partner enumeration and HIV positivity. Compared with participants who had no regular nonmarital sex partner, those who had a regular nonmarital sex partner were more likely to enumerate nonmarital sex partners (adjusted odds ratio [aOR] 3.017, 95% CI 2.560-3.554), have them get tested for HIV (aOR 1.725, 95% CI 1.403-2.122), and have an HIV-positive nonmarital sex partner (aOR 1.962, 95% CI 1.454-2.647).

Conclusions
The percentage of partner enumeration was low, and HIV testing rate was moderate among nonmarital partnerships of HIV-positive individuals. More efforts should be made to improve PS practices among HIV-positive individuals and address the gap in partner enumeration, especially for heterosexual commercial nonmarital partnerships. Additionally, enhancing PS operational skills among health care personnel could increase the overall efficiency of PS uptake in China.
Infância, saúde e corpo em uma abordagem antropológica na educação infantil
Authors: Santos Beatriz Brandão dos , Costa Lenine Bandeira da 
Published: September 2024

Este artigo tem por objetivo apresentar os elementos fundamentais da Infância, Saúde e Corpo em uma abordagem antroplógica ao considerar a criança pequena ativa, produtora de significados e práticas culturais e não apenas como uma receptora passiva de cultura. A metodologia desenvolvida foi de abordagem qualitativa e participativa, com formação de roda de conversas e associação livre de palavras. com as profissionais de educação e com as crianças pequenas em uma creche do município de Duque de Caxias. A análise de dados foi pautada na metodologia do Discurso do Sujeito Coletivo, em conversa com a Teoria das Representações Sociais. Foi evidenciado que a perspectiva antropológica favoreceu a compreensão de que as crianças pequenas sempre têm algo a dizer a respeito de conceitos e poder-se-á conhecê-las em sua profundidade.
With trumpets?
Authors: Fabio Bonizzoni  
Published: September 2024

A good deal of mystery still surrounds some aspects of Arcangelo Corelli's work. Firstly, although he was recognised as the main composer of Sinfonie in Rome around 1700, all of his repertoire of this genre, with the exception of one, seems to have disappeared; secondly, none of his survived orchestral scores contains evidence of the well documented practice of using winds, trumpets in particular, in conjunction with strings. To fill these gaps, speculations have tried to identify, amongst Corelli's works, not only the ones that might have originated as Sinfonie, but also those that might have included trumpets in their original form. This research moves along the same path but sets a slightly different goal: on the one hand it considers that it is virtually impossible to determine if any of Corelli’s survived compositions were originally conceived as Sinfonie with trumpets. On the other hand, it argues that through a study of Lulier's Santa Beatrice d'Este oratorio - a work that preserves the only genuine Corelli's Sinfonia that has survived - and through a comparative analysis of the two Handel's Roman oratorios, it is possible to approach closely the soundscape of Corelli's Sinfonie con trombe. To achieve that goal, in accordance with contemporary Roman examples, newly composed trumpet parts have been integrated into some movements of three concertos from Opus 6. The outcome can be listened in the audio-video material part of this paper. Whether the addition of trumpets on top of a string-only movement could have been improvised, and not planned beforehand with written parts, is open to further speculation.
keywords: Corelli, trumpet, instrumentation, Concerti Grossi, Roman Sinfonie, Research by teachers of the Royal Conservatoire
Developing Madrasah Tourism Experience Model: Examining Tourist Psychological Variables through Systematic Literature Review
Authors: Johari Mohd Hasrul Yushairi , Abd. Gani Arni 
Published: September 2024

This study investigates the Madrasah Tourism Experience Model (MTEM), focusing on its role in understanding the complex interplay between cultural, psychological, and environmental factors in Madrasah tourism. Despite increasing interest in religious and cultural tourism, there is a significant research gap regarding the specific experiences and psychological impacts of visiting Madrasahs. This research addresses this gap by examining key psychological variables influencing tourists’ experiences in these settings. Using a systematic literature review (SLR) methodology, the study analyses 16 carefully selected articles from 327,715 papers to construct a comprehensive model. It highlights how social interaction, cultural engagement, novelty, pleasantness, and relaxation contribute to the tourist experience. The findings extend existing theoretical frameworks by exploring how cultural exchange and hospitality within Madrasah tourism can enhance psychological well-being and satisfaction. Key findings indicate that Madrasah tourism can be significantly improved through tailored experiences, such as guided tours and interactive exhibits, and by creating serene, immersive environments. This approach reaffirms established theories and introduces new insights specific to Madrasah tourism. The implications are significant for both academic researchers and tourism practitioners. The MTEM offers practical guidelines for enhancing visitor experiences and promoting sustainable tourism practices. By integrating cultural exchange and environmental stewardship, Madrasahs can provide more engaging and satisfying experiences, fostering long-term visitor loyalty and contributing to cultural and religious tourism.
Pediatric obstructive sleep apnea-related risk factors: A cross-sectional study
Authors: Machado Saporiti Júlia , Castagno Deborah , Delpizzo Castagno Clarissa , Perpétua Mota Freitas Maria , Leão Goettems Marília , Boscato Noéli 
Published: September 2024

Objectives: This study investigated obstructive sleep apnea (OSA)-related risk factors in children and adolescents.
Materials and methods: Records of 187 subjects from a private medical clinic were reviewed. Overnight polysomnography recordings and self/parent reports were gathered. Descriptive analysis of sociodemographic, anthropometric, sleep quality and sleep architecture variables and OSA diagnosis were performed. Associations between independent variables and OSA diagnosis were assessed through multivariable logistic regression with robust variance, with a significance level of 5%.
Results: 132 participants were diagnosed with OSA, and 55 were classified as “no OSA” (29.41%). Those overweight or obese were 4.97 times more likely to have OSA than those with normal weight (P = 0.005). Those who reported loud snoring were 2.78 times more likely to have OSA than those who reported mild or moderate snoring intensity. A one-unit increase in arousal index leads to 1.39 increase in the odds ratio (OR) of individuals diagnosed with OSA (P < 0.001), and each one-unit increase in sleep efficiency leads to 1.09 higher odds of not having OSA (P = 0.002).
Conclusions: Significantly increased OSA-related risk factors among overweight/obese children and adolescents and among those who had a parental/self-report of loud snoring were found.
Stability of Epinephrine in a Normal Saline Solution
Authors: Sawicki Caroline M. , McKim Daniel B. , Wang Hongrui , Vasas Morgan , Blakeslee Joshua J. , Jatana Courtney A. , Dib Patrick , Cornelius Bryant W. , Wade Spencer D. 
Published: September 2024

Objective
Dilution of concentrated epinephrine prior to intravenous use during clinical emergencies can delay urgent interventions. The objective of this study was to determine whether diluted epinephrine remains stable and sterile over time in common hospital settings.

Methods
Epinephrine samples were prepared by clinically relevant double dilution techniques. Samples were stored in 10-mL syringes and incubated under 1 of 4 simulated hospital environments with a mixture of lighting and temperature settings: 4°C/20°C, with or without fluorescent lighting. Samples were incubated for 0, 15, 30, 60, or 90 days. Capillary zonal electrophoresis was used to quantify the concentration of epinephrine and/or presence of any degradation products. All samples were tested for the presence of bacterial growth using blood agar cultures.

Results
Diluted epinephrine samples remained stable for up to 90 days in all 4 simulated clinical storage conditions. No bacterial colony-forming units were detected in any of the environmental samples regardless of incubation duration, light, or temperature conditions.

Conclusion
Diluted epinephrine for anticipated clinical emergencies may remain clinically useful for up to 90 days, thus improving patient safety, access to medications, and overhead costs by reducing waste.
Media Pembelajaran Audiovisual Interaktif pada Topik Seni Tari Siswa Kelas IV Sekolah Dasar
Authors: Komang Trisna Wikantari  , Kadek Suranata  
Published: September 2024

Kurangnya partisipasi serta keaktifan siswa dalam belajar SBDP Seni tari, atau pasif dalam memahami konsep pembelajaran SBDP Seni tari, dilatarbelakangi oleh proses pembelajarn masih berpusat pada guru atau teacher center. Selain itu guru jarang menggunakan media pembelajaran yang mendukung proses pembelajaran SBDP. Sehingga penelitian ini bertujuan untuk mengembangkan media pembelajaran audiovisual interaktif pada mata pelajaran SBDP topik seni tari materi gerak dasar tari Bali untuk pemula siswa kelas IV SD. Subjek dalam penelitian ini menggunakan 2 orang ahli media, 2 orang ahli tari, 2 orang praktisi, dan 22 siswa uji coba lapangan. Media audiovisual pembelajaran dinyatakan valid dengan kualifikasi sangat baik dari para ahli dengan persentase hasil validitas ahli media diperoleh skor 93% kategori sangat baik, hasil validitas ahli tari diperoleh skor 89,5% kategori baik, hasil validitas praktisi diperoleh skor 88,5% kategori baik. Sedangkan uji coba lapangan untuk mengetahui efektivitas media pembelajaran audiovisual interaktif mendapatkan rata-rata nilai minat belajar sebelum dan sesudah diberikan perlakuan. Rata-rata nilai sebelum diberikan perlakuan yaitu 66 sedangkan rata-rata nilai 93 setelah diberikan perlakuan dan mendapatkan nilai signifikansi lebih kecil. Berdasarkan hasil validitas dan efektivitas media pembelajaran audiovisual interaktif pada mata pelajaran SBDP topik seni tari mampu meningkatkan minat belajar siswa dalam seni tari Bali.
Integrasi Payment Gateway Untuk Donasi Menggunakan Framework Flutter (Studi Kasus Donasi HMTIF UNPAS)
Authors: Fauziah Nurul , Darmawan Fajar , Gusdya Wanda 
Published: September 2024

Dengan adanya covid-19 yang sedang terjadi saat ini (sept 2020) terjadi dampak serius dalam berbagai sektor, tidak hanya sektor eknonomi fenomena tersebut juga berpengaruh dalam sektor pendidikan, khususnya Perguruan Tinggi. Menurut Kementerian Pendidikan dan Kebudayaan (Kemendikbud) bahwa angka putus kuliah meningkat di tengah pandemi Covid-19. Bahkan tingkat putus kuliah bisa mencapai 50 persen (Sept 2020). Donasi adalah sebuah pemberian dari perorangan atau badan hukum kepada pihak tertentu yang mempunyai sifat sukarela dengan tanpa adanya imbalan yang bersifat keuntungan, dengan adanya teknologi internet dan payment gateway kini donasi mulai beralih ke sistem online. Maka dari itu munculah gagasan untuk mengintegrasikan payment gateway pada aplikasi donasi sebagai metode pembayaran online yang dapat meminimalisir keteledoran manusia dan membuat transaksi dapat dilakukan dimana saja dan kapan saja. Penelitian ini menggunakan metodologi dengan tahapan yang dimulai dari Identifikasi masalah, lalu pengumpulan data dengan menggunakan kuesioner dan studi literatur, Analisis dan perancangan yang dilakukan berdasarkan hasil identifikasi masalah serta terhadap teknologi yang digunakan, lalu implementasi bagaimana mengintegrasikan teknologi payment gateway dengan Framework Flutter. Hasil akhir dari penelitian ini adalah dengan dihasilkannya aplikasi donasi berbasis mobile yang sudah terintegrasi dengan payment gateway yang dapat membantu melakukan pembayaran atau transaksi secara online.