bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of DNA methylation measures from dried blood spots and mononuclear cells using the HumanMethylation450k BeadArray
Authors: Dugué Pierre-Antoine , English Dallas R. , MacInnis Robert J. , Jung Chol-Hee , Bassett Julie K. , FitzGerald Liesel M. , Wong Ee Ming , Joo Jihoon E. , Hopper John L. , Southey Melissa C. , Giles Graham G. , Milne Roger L. 
Published: July 2016

AbstractThe reliability of methylation measures from the widely used HumanMethylation450 (HM450K) microarray has not been assessed for DNA from dried blood spots (DBS) or peripheral blood mononuclear cells (PBMC), nor for combined data from different studies. Repeated HM450K methylation measures in DNA from DBS and PBMC samples were available from participants in six case-control studies nested within the Melbourne Collaborative Cohort Study. Reliability was assessed for individual CpGs by calculating the intraclass correlation coefficient (ICC) based on technical replicates (samples repeated in a single study; 126 PBMC, 136 DBS) and study duplicates (samples repeated across studies; 280 PBMC, 769 DBS) using mixed-effects models. Reliability based on technical replicates was moderate for PBMC (median ICC = 0.42), but lower for DBS (median ICC = 0.20). Study duplicates gave lower ICCs than technical replicates. CpGs that were either highly methylated or unmethylated generally had lower ICCs, which appeared to be mostly related to their lower variability. The ICCs for global methylation measures were high, typically greater than 0.70. The reliability of methylation measures determined by the HM450K microarray is wide-ranging and depends primarily on the variability in methylation at individual CpG sites. The power of association studies is low for a substantial proportion of CpGs in the HM450K assay.
Black phosphorus: a two-dimension saturable absorption material for mid-infrared Q-switched and mode-locked fiber lasers
Authors: Li Jianfeng , Luo Hongyu , Zhai Bo , Lu Rongguo , Guo Zhinan , Zhang Han , Liu Yong 
Published: July 2016

AbstractBlack phosphorus (BP) as a novel class of two-dimension (2D) materials has recently attracted enormous attention as a result of its unique physical and chemical features. The remarkably strong light-matter interaction and tunable direct band-gap at a wide range make it an ideal candidate especially in the mid-infrared wavelength region as the saturable absorber (SA). In this paper, the simple and effective liquid phase exfoliation (LPE) method was used to fabricate BP. By introducing the same BP SA into two specifically designed rare earth ions doped fluoride fiber lasers at mid-infrared wavebands, Q-switching with the pulse energy of 4.93 μJ and mode-locking with the pulse duration of 8.6 ps were obtained, respectively. The operation wavelength of ~2970 nm for generated pulse is the reported longest wavelength for BP SA based fiber lasers.
PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function
Authors: Kerr Gary W. , Wong Jin Huei , Arumugam Prakash 
Published: July 2016

AbstractPP2ACdc55 is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2ACdc55 activity undergo a premature exit from meiosis I which results in a failure to form bipolar spindles and divide nuclei. This defect is largely due to its role in negatively regulating the Cdc Fourteen Early Anaphase Release (FEAR) pathway. PP2ACdc55 prevents nucleolar release of the Cdk (Cyclin-dependent kinase)-antagonising phosphatase Cdc14 by counteracting phosphorylation of the nucleolar protein Net1 by Cdk. CDC55 was identified in a genetic screen for monopolins performed by isolating suppressors of spo11Δ spo12Δ lethality suggesting that Cdc55 might have a role in meiotic chromosome segregation. We investigated this possibility by isolating cdc55 alleles that suppress spo11Δ spo12Δ lethality and show that this suppression is independent of PP2ACdc55’s FEAR function. Although the suppressor mutations in cdc55 affect reductional chromosome segregation in the absence of recombination, they have no effect on chromosome segregation during wild type meiosis. We suggest that Cdc55 is required for reductional chromosome segregation during achiasmate meiosis and this is independent of its FEAR function.
Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity
Authors: Tang Tao , Deng Yan , Chen Jiao , Zhao Yi , Yue Ruifeng , Choy Kwong Wai , Wang Chi Chiu , Du Quan , Xu Yan , Han Linxiao , Chung Tony Kwok Hung 
Published: July 2016

AbstractAlthough RNA interference may become a novel therapeutic approach for cancer treatment, target-site accumulation of siRNA to achieve therapeutic dosage will be a major problem. Microneedle represents a better way to deliver siRNAs and we have evaluated for the first time the capability of a silicon microneedle array for delivery of Gapdh siRNA to the skin in vivo and the results showed that the microneedle arrays could effectively deliver siRNA to relevant regions of the skin noninvasively. For the further study in this field, we evaluated the efficacy of the injectable microneedle device for local delivery of siRNA to the mouse xenograft. The results presented here indicate that local administration of siRNA through injectable microneedle could effectively deliver siRNA into the tumor region, and inhibit tumor progression without major adverse effects.
IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway
Authors: Chen Hongbin , Lin Wei , Zhang Yixian , Lin Longzai , Chen Jianhao , Zeng Yongping , Zheng Mouwei , Zhuang Zezhong , Du Houwei , Chen Ronghua , Liu Nan 
Published: July 2016

AbstractAs a classic immunoregulatory and anti-inflammatory cytokine, interleukin-10 (IL-10) provides neuroprotection in cerebral ischemia in vivo or oxygen-glucose deprivation (OGD)-induced injury in vitro. However, it remains blurred whether IL-10 promotes neurite outgrowth and synapse formation in cultured primary cortical neurons after OGD injury. In order to evaluate its effect on neuronal apoptosis, neurite outgrowth and synapse formation, we administered IL-10 or IL-10 neutralizing antibody (IL-10NA) to cultured rat primary cortical neurons after OGD injury. We found that IL-10 treatment activated the Janus kinase 1 (JAK1)/signal transducers and activators of transcription 3 (STAT3) signaling pathway. Moreover, IL-10 attenuated OGD-induced neuronal apoptosis by down-regulating the Bax expression and up-regulating the Bcl-2 expression, facilitated neurite outgrowth by increasing the expression of Netrin-1 and promoted synapse formation in cultured primary cortical neurons after OGD injury. These effects were partly abolished by JAK1 inhibitor GLPG0634. Contrarily, IL-10NA produced opposite effects on the cultured cortical neurons after OGD injury. Taken together, our findings suggest that IL-10 not only attenuates neuronal apoptosis, but also promotes neurite outgrowth and synapse formation via the JAK1/STAT3 signaling pathway in cultured primary cortical neurons after OGD injury.
Plasminogen Activator Inhibitor-1 in depression: Results from Animal and Clinical Studies
Authors: Jiang Haitang , Li Xiaoli , Chen Suzhen , Lu Na , Yue Yingying , Liang Jinfeng , Zhang Zhijun , Yuan Yonggui 
Published: July 2016

AbstractEvidence suggests that plasminogen activator inhibitor-1 (PAI-1) is a stress-related factor, and serum PAI-1 levels are increased in patients with major depressive disorders (MDD). Herein, we analysed PAI-1 protein levels in the brain, cerebrospinal fluid (CSF) and serum of rodents exposed to chronic unpredictable mild stress or treated with escitalopram. In addition, we examined PAI-1 concentrations in serum obtained from 17 drug-free depressed patients before and after escitalopram treatment. We found that PAI-1 expression was increased in area 1 of the cingulate cortex and prelimbic cortex of the medial prefrontal cortex as well as in the hippocampal cornu ammonis 3 and dentate gyrus in stressed rats. A downregulation of PAI-1 following chronic escitalopram treatment was also found. PAI-1 levels were higher in the CSF and serum in stressed rats than in controls, although the difference did not reach statistical significance in the serum. Escitalopram treatment significantly decreased PAI-1 levels in the serum, but not in the CSF. MDD patients had significantly greater serum PAI-1 concentrations than controls. Our results suggest that PAI-1 is implicated in the pathophysiology of depression.
Resolution enhancement using plasmonic metamask for wafer-scale photolithography in the far field
Authors: Baek Seunghwa , Kang Gumin , Kang Min , Lee Chang-Won , Kim Kyoungsik 
Published: July 2016

AbstractResolution enhancement in far-field photolithography is demonstrated using a plasmonic metamask in the proximity regime, in which Fresnel diffraction is dominant. The transverse magnetic component of the diffracted wave from the photomask, which reduces the pattern visibility and lowers the resolution, was successfully controlled by coupling with the anti-symmetric mode of the excited surface plasmon. We obtained a consistently finely-patterned photoresist surface at a distance of up to 15 μm from the mask surface for 3-μm-pitch slits because of conserved field visibility when propagating from the near-field to the proximity regime. We confirmed that sharp edge patterning is indeed possible when using a wafer-scale photomask in the proximity photolithography regime. Our plasmonic metamask method produces cost savings for ultra-large-scale high-density display fabrication by maintaining longer photomask lifetimes and by allowing sufficient tolerance for the distance between the photomask and the photoresist.
Scattering effect of the high-index dielectric nanospheres for high performance hydrogenated amorphous silicon thin-film solar cells
Authors: Yang Zhenhai , Gao Pingqi , Zhang Cheng , Li Xiaofeng , Ye Jichun 
Published: July 2016

AbstractDielectric nanosphere arrays are considered as promising light-trapping designs with the capability of transforming the freely propagated sunlight into guided modes. This kinds of designs are especially beneficial to the ultrathin hydrogenated amorphous silicon (a-Si:H) solar cells due to the advantages of using lossless material and easily scalable assembly. In this paper, we demonstrate numerically that the front-sided integration of high-index subwavelength titanium dioxide (TiO2) nanosphere arrays can significantly enhance the light absorption in 100 nm-thick a-Si:H thin films and thus the power conversion efficiencies (PCEs) of related solar cells. The main reason behind is firmly attributed to the strong scattering effect excited by TiO2 nanospheres in the whole waveband, which contributes to coupling the light into a-Si:H layer via two typical ways: 1) in the short-waveband, the forward scattering of TiO2 nanospheres excite the Mie resonance, which focuses the light into the surface of the a-Si:H layer and thus provides a leaky channel; 2) in the long-waveband, the transverse waveguided modes caused by powerful scattering effectively couple the light into almost the whole active layer. Moreover, the finite-element simulations demonstrate that photocurrent density (Jph) can be up to 15.01 mA/cm2, which is 48.76% higher than that of flat system.
Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1
Authors: Ge Xiao Na , Ha Sung Gil , Greenberg Yana G. , Rao Amrita , Bastan Idil , Blidner Ada G. , Rao Savita P. , Rabinovich Gabriel A. , Sriramarao P. 
Published: July 2016

SignificanceAllergic asthma is a chronic airway disease, and the number of individuals with asthma continues to grow. Eosinophils recruited to allergic airways contribute significantly to airway inflammation via release of proinflammatory mediators that cause epithelial tissue damage, bronchoconstriction, and airway remodeling. Here we show that galectin-1 (Gal-1), an endogenous immunoregulatory lectin, binds to eosinophil-expressed surface glycans to inhibit cell migration and induce apoptosis. Using a mouse model of allergic asthma, we show that mice lacking Gal-1 exhibit increased airway eosinophils and airway hyperresponsiveness compared with wild-type mice. Because Gal-1 plays an important role in regulating airway inflammation, identifying pathways to induce Gal-1 synthesis and/or favor its biological activity might enable exploitation of its proresolving function to suppress allergic asthma.
What cognitive processes are likely to be exercised by bilingualism and does this exercise lead to extra-linguistic cognitive benefits?
Authors: Klein Raymond M. 
Published: July 2016

Abstract
I begin with some personal history that illuminates my background and my interest in the questions posed in this article’s title (What cognitive processes are likely to be exercised by bilingualism and does this exercise lead to extra-linguistic cognitive benefits?). A brief overview of historical interest in these questions follows, with emphasis on the landmark study by Peel and Lambert (1962) and the seminal ideas in Bialystok’s (2001) book: Bilingualism in Development: Language, Literacy and Cognition. Three cognitive processes (monitoring, selection mediated by inhibition, and switching) are likely to be “exercised” in the bilingual mind and, especially, in the bilingual context. Yet, despite a few early studies that reported evidence for bilingual advantages in these cognitive processes, the thorough empirical reviews presented here and in previous papers by Hilchey (Hilchey & Klein, 2011; Hilchey, Saint-Aubin & Klein, 2015) and others, suggest that there are no extra-linguistic cognitive benefits of multi-lingual mastery.
Antecedent Generics: How Capes, Lakes, Mounts, and Points Are Named in the Antipodes
Authors: Tent Jan 
Published: July 2016

Toponymic literature often mentions that the names of geographic features generally have the structure: specific + generic. While this is often the case, there are a set of geographic features that regularly do not follow this sequence. These are capes, lakes, mountains, and points. Their order of elements is often the reverse: generic + specific. By using toponyms from the Gazetteer of Australia and the New Zealand Gazetteer, this article shows there is indeed a distinct and suggestive pattern to the names that these features bear, explores this phenomenon and attempts to discover reasons for this trend.
Concluding Thoughts
Authors: Degiuli Francesca 
Published: July 2016

Abstract
Chapter 8 provides a review of the many topics covered throughout the book and emphasizes how, notwithstanding some minor transformations, the organization of eldercare in Italy continues to rely heavily on the presence of im/migrant women workers. This presence is crucial not only for Italian families that without im/migrant women would be crushed by the growing demands of care placed upon them but also for the Italian welfare state that due to the work of these women is able to manage the current eldercare crisis without addressing the changes that have occurred and are occurring in Italian society. Instead of addressing the growing need of the Italian elders and their families with an appropriate discussion of the role of the welfare state and the restructuring of its services, the Italian state utilizes contradictory immigration policies to provide a market solution to the current eldercare crisis.
Radiocarbon Dating and Egyptian Chronology—From the “Curve of Knowns” to Bayesian Modeling
Authors: Höflmayer Felix 
Published: July 2016

AbstractRadiocarbon dating has become a standard dating method in archaeology almost all over the world. However, in the field of Egyptology and Near Eastern archaeology, the method is still not fully appreciated. Recent years have seen several major radiocarbon projects addressing Egyptian archaeology and chronology that have led to an intensified discussion regarding the application of radiocarbon dating within the field of Egyptology. This chapter reviews the contribution of radiocarbon dating to the discipline of Egyptology, discusses state-of-the-art applications and their impact on archaeological as well as chronological questions, and presents open questions that will be addressed in the years to come.
Beyond the standard model of particle physics
Authors: Virdee T. S. 
Published: July 2016

The Large Hadron Collider (LHC) at CERN and its experiments were conceived to tackle open questions in particle physics. The mechanism of the generation of mass of fundamental particles has been elucidated with the discovery of the Higgs boson. It is clear that the standard model is not the final theory. The open questions still awaiting clues or answers, from the LHC and other experiments, include: What is the composition of dark matter and of dark energy? Why is there more matter than anti-matter? Are there more space dimensions than the familiar three? What is the path to the unification of all the fundamental forces? This talk will discuss the status of, and prospects for, the search for new particles, symmetries and forces in order to address the open questions.
This article is part of the themed issue ‘Unifying physics and technology in light of Maxwell's equations’.
Multi-attribute grey target decision method with three-parameter interval grey number
Authors: Li Ye , Zhu Shanli , Guo San-dang 
Published: July 2016

Purpose
– The purpose of this paper is to propose the grey target decision method based on three-parameter interval grey number for dealing with multi-attribute decision-making problems under uncertain environment.

Design/methodology/approach
– First, the kernel and ranking method of three-parameter interval grey number are defined, which is the basis of determining the positive and negative bull’s-eye. Next, a new distance measure of three-parameter interval grey number is defined in view of the importance of the “center of gravity” point. Furthermore, a new comprehensive bull’s-eye distance is proposed based on the kernel which integrates the distance between different attributes to the positive and negative bull’s-eye. Then attribute weights are obtained by comprehensive bull’s-eye distance minimum and grey entropy maximization.

Findings
– The paper provides a grey target decision method based on three-parameter interval grey number and example analysis shows that the method proposed in this paper is more reasonable and effective.

Research limitations/implications
– If we have a better understanding of the distribution characteristics of three-parameter interval grey number, it is possible to have a more reasonable measure of the distance of three-parameter interval grey number.

Practical implications
– The paper provides a grey target decision method, which can help decision maker deal with multi-attribute decision-making problems under uncertain environment.

Originality/value
– This paper proposed the kernel and ranking method of three-parameter interval grey number, and defined a new distance measure of three-parameter interval grey number and proposed a new comprehensive bull’s-eye distance, Furthermore, this paper structured a grey target decision method based on three-parameter interval grey number.
Grey social media engagement analysis
Authors: Delcea Camelia 
Published: July 2016

Purpose– Recent studies have shown that customers are more likely to buy a certain product or service from a company they can follow or contact on social media. Moreover, the customers feel a stronger relationship with the companies they are interacting in the virtual networks. But have the companies succeed in getting everything from this strong relationship? Are their online advertising campaigns getting to the right customers? Is there any connection between the social media engagement and the decisions users are taking? This is going to be shaped in this paper through a grey analysis applied to the selected variables. The paper aims to discuss these issues.Design/methodology/approach– As the nature of the relationships created in the online social networks is characterized by incomplete information, the analysis will make used of the concepts and means offered by the grey systems theory, a theory that have obtained good results over the time when used on uncertain situations.Findings– By applying a grey relational analysis (GRA) to the considered variables, a strong relationship between the decision easiness and both time spent on social media platforms and number of the accessed websites has been identified. Moreover, it has been determined that the decision happiness is closely related to the companies’ websites and their commercials.Research limitations/implications– The present paper shapes the relationship between the usage of online social media and consumers’ decision-making process and decision-making happiness. Due to the fact that the online social media includes billions of users worldwide, the study has some limitations due to the users’ number.Originality/value– The paper uses GRA for drawing the connections between the online social networks reality and its influence to users’ every-day life. Considering the present findings, it can be underlined that the identification of the persons which are influential becomes important in order to get to the proper targeted customers.