bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water, water, everywhere
Authors: McDonald-Kerr Lachlan 
Published: February 2017

PurposeThis paper aims to examine how social and environmental issues were accounted for and traded off within decision-making for Australia’s largest seawater desalination plant. This is done through an investigation of disclosures contained within key publicly available documents pertaining to the project.Design/methodology/approachThe study deploys content analysis to initially identify relevant disclosures. Themes and subthemes are based on definitions of social and environmental accounting adapted from prior research. Relevant information was used to develop “silent accounts” to identify and analyse accountability issues in the case.FindingsIt was found that a number of claims made throughout reporting were unsupported or insufficiently explained. At the same time, it is found that various forms of basic measurements used to describe social and environmental issues conveyed the rationale of decision makers. It is concluded that many of the claims were asserted rather than evidenced; yet, the manner and context of their presentation gave them the appearance of being incontestable truths. Further, it is argued that the portrayal of social and environmental issues through measurable means is emblematic of values associated with contemporary neoliberal and public sector reforms.Research limitations/implicationsThe findings and conclusions of this study are contextually bound and therefore limited to this case.Practical implicationsThis paper illustrates problems with the reporting of non-financial information and strengthens our understanding of the use of “silent accounting”. It illustrates the value of this approach to research examining accounting and accountability issues.Originality/valueThe findings contribute to the literature on social and environmental accounting by providing unique empirical analysis of non-financial disclosures within publicly available reporting.
Promoting and managing collaborative performance
Authors: Allal-Chérif Oihab 
Published: February 2017

Purpose
This paper aims to demonstrate that collaboration is the best way to create sustainable value and to set new indicators to measure collaborative performance.

Design/methodology/approach
The methodology is based on the study of several cases from industrial international firms that have successfully build strong partnerships with their suppliers.

Findings
If collaboration is fashionable nowadays, it is not a new behavior. Entrepreneurs have chosen to collaborate with suppliers rather than exploit them for decades. Cooperating in the long term with business partners generates outstanding performance. However, most companies continue to have essentially transactional relationship based on the optimization of financial indicators, rather than fostering the quality of their trade and mutual loyalty. This paper answers the questions why and how to promote and manage collaborative performance.

Originality/value
This paper connects the concepts of collaboration, innovation and sustainable value creation. It questions traditional KPIs and the fear of risk and failure.
Crafting a winning innovation strategy
Authors: Sharmelly Rifat 
Published: February 2017

Purpose
This paper aims to identify the innovation strategies of the most successful organizations and demonstrate how business organizations can outperform their rivals.

Design/methodology/approach
This paper is based on a review of “How successful organizations drive innovation” by Ikeda and Marshall (2016).

Findings
Top performing organizations create organizational structures and functions to sustain innovation, create a culture of innovation and design processes to create innovation. To sustain innovation, organizations create a balance between innovation objectives and business objectives, adopt open innovation and form dedicated innovation teams. Organizations create a culture of innovation through a clear focus on innovation, agility and promoting an innovation culture. Finally, successful organizations design processes to create innovation, adopting strategies of generating new ideas from various sources, ensuring stable and secure innovation funding and deploying explicit innovation measurement.

Practical implications
The paper provides strategic insights and clear steps for all organizations to succeed in their innovation ventures.

Originality/value
Based on the review, this paper illustrates how existing and prospective companies gain a competitive edge in innovation through organizational structures, culture and processes.
The new role of the purchasing function in the management of the extended enterprise
Authors: Cracco Bruno 
Published: February 2017

Purpose
This paper aims to explore the new role of the purchasing function in the management of the extended enterprise.

Design/methodology/approach
This study uses field experience and focus group with CPOs.

Findings
The purchasing function can play a key role in its own company business models disruption. Innovation detection and fostering could be managed by the purchasing function, acting as external resources development.

Originality/value
This paper is an original viewpoint article from an author experienced in the field.
Methylamine as a nitrogen source for microorganisms from a coastal marine environment
Authors: Taubert Martin , Grob Carolina , Howat Alexandra M. , Burns Oliver J. , Pratscher Jennifer , Jehmlich Nico , von Bergen Martin , Richnow Hans H. , Chen Yin , Murrell J. Colin 
Published: February 2017

SummaryNitrogen is a key limiting resource for biomass production in the marine environment. Methylated amines, released from the degradation of osmolytes, could provide a nitrogen source for marine microbes. Thus far, studies in aquatic habitats on the utilization of methylamine, the simplest methylated amine, have mainly focussed on the fate of the carbon from this compound. Various groups of methylotrophs, microorganisms that can grow on one‐carbon compounds, use methylamine as a carbon source. Non‐methylotrophic microorganisms may also utilize methylamine as a nitrogen source, but little is known about their diversity, especially in the marine environment. In this proof‐of‐concept study, stable isotope probing (SIP) was used to identify microorganisms from a coastal environment that assimilate nitrogen from methylamine. SIP experiments using 15N methylamine combined with metagenomics and metaproteomics facilitated identification of active methylamine‐utilizing Alpha‐ and Gammaproteobacteria. The draft genomes of two methylamine utilizers were obtained and their metabolism with respect to methylamine was examined. Both bacteria identified in these SIP experiments used the γ‐glutamyl‐methylamide pathway, found in both methylotrophs and non‐methylotrophs, to metabolize methylamine. The utilization of 15N methylamine also led to the release of 15N ammonium that was used as nitrogen source by other microorganisms not directly using methylamine.
MST50 is involved in multiple MAP kinase signaling pathways in Magnaporthe oryzae
Authors: Li Guotian , Zhang Xue , Tian Huan , Choi Yoon‐E , Tao W. Andy , Xu Jin‐Rong 
Published: February 2017

SummaryAppressorium formation plays a critical role in Magnaporthe oryzae. Mst50 is an adapter protein of the Mst11‐Mst7‐Pmk1 cascade that is essential for appressorium formation. To further characterize its functions, affinity purification was used to identify Mst50‐interacting proteins (MIPs) in this study. Two of the MIPs are Mst11 and Mst7 that are known to interact with Mst50 for Pmk1 activation. Surprisingly, two other MIPs are Mck1 and Mkk2 that are the upstream kinases of the Mps1 pathway. Domain deletion analysis showed that the sterile alpha‐motif of Mst50 but not the Ras‐association domain was important for its interaction with Mck1 and responses to cell wall and oxidative stresses. The mst50 mutant was reduced in Mps1 activation under stress conditions. MIP11 encodes a RACK1 protein that also interacted with Mck1. Deletion of MIP11 resulted in defects in cell wall integrity, Mps1 phosphorylation and plant infection. Furthermore, Mst50 interacted with histidine kinase Hik1, and the mst50 mutant was reduced in Osm1 phosphorylation. These results indicated that Mst50 is involved in all three MAPK pathways in M. oryzae although its functions differ in each pathway. Several MIPs are conserved hypothetical proteins and may be involved in responses to various signals and crosstalk among signaling pathways.
Geomorphic reconstruction of formation and recession processes of waterfalls of the Kaminokawa river basin on Osumi Peninsula, southern Kyushu, Japan
Authors: Yoshida Hidetsugu , Hayakawa Yuichi S. , Takanami Shintaro , Hikitsu Akira , Ohsaka Saki , Ishii Ryo 
Published: February 2017

AbstractTo assess the geomorphological importance of waterfall recession in volcanic bedrock, we examined recession rates of six waterfalls in the lower reaches of Kaminokawa river basin on the Osumi Peninsula in southern Kyushu. The examination was performed with an empirical equation that uses a dimensionless parameter obtained by dimensional analysis of relevant measured factors, including erosive force, size of waterfall, and bedrock resistance. Welded Ata ignimbrite, formed at approximately 110 ka, may have played an initiating role to maintain such waterfalls because it resists weathering more than other local rocks. Estimated recession rates for the six waterfalls range from 0.2 to 3.0 cm/y, which compare with estimated rates for waterfalls in another region characterised by welded ignimbrite. Comparison of equation‐derived recession rates of waterfalls with actual recession distances from confluences supports the idea that an original waterfall will subsequently split into two distinct waterfalls when it recesses past an upstream junction of two channels. Our findings revealed that all six waterfalls likely would have been at almost the same point lower in the watershed in the past, marking the general site of the original waterfall. Moreover, the ancestral original waterfall is highly likely to have started from a point between the caldera rim and present river mouth. There, a knickpoint was likely caused by the river dropping into an inner part of the caldera, possibly just after the eruption of the Ata ignimbrite. The waterfall erodes upstream away from the caldera basin, and this happens to be to the east.
The empirical Bayes estimators of fine‐scale population structure in high gene flow species
Authors: Kitada Shuichi , Nakamichi Reiichiro , Kishino Hirohisa 
Published: February 2017

AbstractAn empirical Bayes (EB) pairwise FST estimator was previously introduced and evaluated for its performance by numerical simulation. In this study, we conducted coalescent simulations and generated genetic population structure mechanistically, and compared the performance of the EBFST with Nei's GST, Nei and Chesser's bias‐corrected GST (GST_NC), Weir and Cockerham's θ (θWC) and θ with finite sample correction (θWC_F). We also introduced EB estimators for Hedrick’ G’ST and Jost’ D. We applied these estimators to publicly available SNP genotypes of Atlantic herring. We also examined the power to detect the environmental factors causing the population structure. Our coalescent simulations revealed that the finite sample correction of θWC is necessary to assess population structure using pairwise FST values. For microsatellite markers, EBFST performed the best among the present estimators regarding both bias and precision under high gene flow scenarios (). For 300 SNPs, EBFST had the highest precision in all cases, but the bias was negative and greater than those for GST_NC and θWC_F in all cases. GST_NC and θWC_F performed very similarly at all levels of FST. As the number of loci increased up to 10 000, the precision of GST_NC and θWC_F became slightly better than for EBFST for cases with , even though the size of the bias remained constant. The EB estimators described the fine‐scale population structure of the herring and revealed that ~56% of the genetic differentiation was caused by sea surface temperature and salinity. The R package finepop for implementing all estimators used here is available on CRAN.
Necrotizing fasciitis as a complication of odontogenic infection: a review of management and case series
Authors: Bayetto K , Cheng A , Sambrook P 
Published: February 2017

AbstractBackgroundThe aims of the present study were to establish the incidence of head and neck necrotizing fasciitis (NF) in the Adelaide Oral and Maxillofacial Surgery Unit; review the current literature regarding the management of head and neck NF; and determine the evidence for the role of hyperbaric oxygen therapy in the management of NF.MethodsA retrospective audit of all patients admitted to the Royal Adelaide Hospital Oral and Maxillofacial Surgery Unit 2006–2015 with severe odontogenic infections was carried out. Patient demographics were recorded and treatment details were collected and analysed.ResultsA total of 672 patients were admitted for management of severe odontogenic infections. Of these, three were identified as NF. One case was treated using hyperbaric oxygen as an adjunct to conventional surgical and medical management. Two cases were managed using aggressive surgical management alone. Two patients survived. The incidence of head and neck NF in South Australia is 48/100 000 infections per year.ConclusionsThe first‐line treatment of severe odontogenic infections remains conventional surgical and medical management; however, hyperbaric oxygen therapy may have an additional role in the management of NF and other rare severe infections in medically complex patients.
Identification of a new Y chromosome haplogroup in Spanish native cattle
Authors: Pelayo R. , Penedo M. C. T. , Valera M. , Molina A. , Millon L. , Ginja C. , Royo L. J. 
Published: February 2017

SummaryThe aim of this work was to perform a thorough analysis of the diversity of Y‐haplotypes in Spanish cattle. A total of 207 Bos taurus males were sampled across 25 European breeds, with a special focus on rare, local Spanish populations. Animals were genotyped with five Y‐specific microsatellites (INRA189, UMN0103, UMN0307, BM861 and BYM1), two indels (ZFY10 and USP9Y) and one SNP (UTY19). A new haplogroup, distinct from those described by Götherström et al. (2005), was identified and named Y1.2. Samples representing the three B. taurus Y‐haplogroups were genotyped for four additional Y chromosome SNPs (rs121919254, rs121919281, rs121919323 and rs137049553). Among these SNPs, only rs121919281 was informative in B. taurus and helped to confirm the new Y1.2 haplogroup. Analysis of a larger dataset of standardized haplotypes for 1507 individuals from 57 populations from Spain, other European countries and Africa showed the new Y1.2 haplogroup to be found exclusively in Spanish breeds. This finding reinforces the importance of local Spanish cattle as reservoirs of genetic diversity as well as the importance of the Iberian Peninsula in the history of cattle.
Causal or spurious relationship? Climate and the distribution of Phelsuma geckos on Grand Comoro Island
Authors: Hawlitschek Oliver , Brückmann Boris , Glaw Frank 
Published: February 2017

AbstractThe volcanic island of Grand Comoro, Malagasy biogeographic region, is inhabited by three species of Phelsuma day geckos; two island‐endemic taxa (Phelsuma comorensis and Phelsuma v‐nigra comoraegrandensis) and the introduced Phelsuma dubia. Phelsuma comorensis is restricted to elevations of greater than 150 m above sea level on the northern of the island's two volcanoes and is the only Phelsuma above 300 m. The other species are widespread at low elevations but also reach levels above 900 m at the southern volcano. To investigate these divergent distribution patterns, we used environmental niche models based on climate and habitat data and tested whether predicted climate change may influence species distributions. Analyses of niche overlap did not show significant differences between present‐day and predicted future potential distributions of any Phelsuma species studied, which could be seen as an indicator of resilience towards climate change. Climate models reflected the restricted distribution of P. comorensis with precipitation of the wettest month detected as most important variable, whereas habitat models predicted an island‐wide distribution. While climate appears to determine the distribution of P. comorensis, we propose isolation by migration barriers as an alternative and discuss the detection of causal versus spurious relationships in ecological niche models.
Hepatic nucleotide binding oligomerization domain‐like receptors pyrin domain‐containing 3 inflammasomes are associated with the histologic severity of non‐alcoholic fatty liver disease
Authors: Mitsuyoshi Hironori , Yasui Kohichiroh , Hara Tasuku , Taketani Hiroyoshi , Ishiba Hiroshi , Okajima Akira , Seko Yuya , Umemura Atsushi , Nishikawa Taichiro , Yamaguchi Kanji , Moriguchi Michihisa , Minami Masahito , Itoh Yoshito 
Published: February 2017

AbstractAimTo examine the role of nucleotide binding oligomerization domain‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasomes in the development of non‐alcoholic fatty liver disease (NAFLD).MethodsLevels of mRNAs encoding NLRP3, apoptosis‐associated speck‐like protein containing a caspase recruitment domain, procaspase‐1, interleukin (IL)‐1β, and IL‐18 were quantified by real‐time polymerase chain reaction in 91 liver samples and 37 blood samples from biopsy‐proven patients with NAFLD. Adiponutrin (also called PNPLA3) polymorphisms (rs738409, C > G) were determined in 74 samples by genotyping assays. Serum IL‐1β and IL‐18 levels were measured by enzyme‐linked immunosorbent assay and liver tissue caspase‐1 expression by immunostaining.ResultsHepatic NLRP3, procaspase‐1, IL‐1β, and IL‐18 mRNA levels were significantly higher in NAFLD patients than in controls and were significantly associated with adiponutrin G alleles. Blood procaspase‐1 mRNA was significantly higher in NAFLD patients than in healthy controls. Hepatic procaspase‐1 and IL‐1β mRNA levels correlated significantly with lobular inflammation, hepatocyte ballooning, and NAFLD activity score. Serum IL‐18 levels were significantly higher in NAFLD patients than in controls, while IL‐1β levels were non‐significantly higher. Serum IL‐1β and IL‐18 concentrations correlated significantly with steatosis, NAFLD activity score, and transaminase levels. Serum IL‐1β levels were significantly associated with adiponutrin G alleles. Scattered caspase‐1‐positive cells were present in portal tracts and inflammatory foci and around ballooning hepatocytes. Immunofluorescence staining showed that caspase‐1 colocalized with the macrophage marker CD68.ConclusionsThe NLRP3 inflammasomes are primed in the liver, influenced by adiponutrin genotypes, and activated in Kupffer cells and/or macrophages in NAFLD, leading to histological progression through IL‐1β and IL‐18 production.
Improved detection of clinically relevant wound bacteria using autofluorescence image‐guided sampling in diabetic foot ulcers
Authors: Ottolino‐Perry Kathryn , Chamma Emilie , Blackmore Kristina M , Lindvere‐Teene Liis , Starr Danielle , Tapang Kim , Rosen Cheryl F , Pitcher Bethany , Panzarella Tony , Linden Ron , DaCosta Ralph S 
Published: February 2017

AbstractClinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to antibiotics. The Levine swabbing technique may be suboptimal because it samples only the wound bed, missing other diagnostically relevant areas of the wound, which may contain clinically significant bacteria. Thus, there is a clinical need to improve the reliability of microbiological wound sampling. To address this, a handheld portable autofluorescence (AF) imaging device that detects bacteria in real time, without contrast agents, was developed. Here, we report the results of a clinical study evaluating the use of real‐time AF imaging to visualise bacteria in and around the wound bed and to guide swabbing during the clinical assessment of diabetic foot ulcers, compared with the Levine technique. We investigated 33 diabetic foot ulcers (n = 31 patients) and found that AF imaging more accurately identified the presence of moderate and/or heavy bacterial load compared with the Levine technique (accuracy 78% versus 52%, P = 0·048; adjusted diagnostic odds ratio 7·67, P < 0·00022 versus 3·07, P = 0·066) and maximised the effectiveness of bacterial load sampling, with no significant impact on clinical workflow. AF imaging may help clinicians better identify the wound areas with clinically significant bacteria, and maximise sampling of treatment‐relevant pathogens.
The plasticity of germ cell cancers and its dependence on the cellular microenvironment
Authors: Nettersheim Daniel , Schorle Hubert 
Published: February 2017

AbstractSo far, the understanding of germ cell cancer (GCC) pathogenesis is based on a model, where seminomas and non‐seminomas represent distinct entities although originating from a common precursor termed germ cell neoplasia in situ (GCNIS). Embryonal carcinomas (ECs), the stem cell population of the non‐seminomas, is pluri‐ to totipotent and able to differentiate into cells of all three germ layers, giving rise to teratomas or tumours mimicking extraembryonic tissues (yolk sac tumours, choriocarcinomas). With regard to gene expression, (epi)genetics and histology, seminomas are highly similar to GCNIS and primordial germ cells, but limited in development. It remains elusive, whether this block in differentiation is controlled by cell intrinsic mechanisms or by signals from the surrounding microenvironment. Here, we reviewed the recent literature emphasizing the plasticity of GCCs, especially of seminomas. We propose that this plasticity is controlled by the microenvironment, allowing seminomas to transit into an EC or mixed non‐seminoma and vice versa. We discuss several mechanisms and routes of reprogramming that might be responsible for this change in the cell fate. We finally integrate this plasticity into a new model of GCC pathogenesis, allowing for an alternative view on the dynamics of GCC development and progression.
Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles
Authors: Salatin Sara , Yari Khosroushahi Ahmad 
Published: February 2017

AbstractNanoparticulate drug/gene carriers have gained much attention in the past decades because of their versatile and tunable properties. However, efficacy of the therapeutic agents can be further enhanced using naturally occurring materials‐based nanoparticles. Polysaccharides are an emerging class of biopolymers; therefore, they are generally considered to be safe, non‐toxic, biocompatible and biodegradable. Considering that the target of nanoparticle‐based therapeutic strategies is localization of biomedical agents in subcellular compartments, a detailed understanding of the cellular mechanism involved in the uptake of polysaccharide‐based nanoparticles is essential for safe and efficient therapeutic applications. Uptake of the nanoparticles by the cellular systems occurs with a process known as endocytosis and is influenced by the physicochemical characteristics of nanoparticles such as size, shape and surface chemistry as well as the employed experimental conditions. In this study, we highlight the main endocytosis mechanisms responsible for the cellular uptake of polysaccharide nanoparticles containing drug/gene.