bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refractive errors characteristic of the patients at the Children’s Ophthalmology Outpatient Department of Kauno klinikos Hospital (Lithuanian University of Health Sciences) from 1 January 2012 to 31 December 2012
Authors: Čiumbaraitė Rasa , Liutkevičienė Rasa 
Published: July 2017

Background. The purpose of our study was to assess the distribution and patterns of refractive errors in children for the proper planning of paediatric eye care at the centre.
Material and methods. The study was conducted in the hospital of the Lithuanian University of Health Sciences in Kaunas, from 1 January 2012 to 31 December 2012. During this period, a total of 11,406 children, aged 0–18 years, were evaluated at the outpatient department of paediatric ophthalmology, Kauno klinikos, the Lithuanian University of Health Sciences. All the children underwent a complete ophthalmic examination with cycloplegic refraction.
Results. Myopia increased from 1.5% (95% CI:1.2, 1.8) in the age group of 0–1 to 44.7% (95% CI:43.46, 45.94) in the age group of 14–18 (p
Clinical characteristics and long-term survival differences of the ANCA-associated vasculitis group: a cross-sectional study of 27 patients
Authors: Dadonienė Jolanta , Kumžaitė Gintarė , Mačiulytė Rimvydė , Miltinienė Dalia 
Published: July 2017

Objective. The goal of this study was to describe long-term patient survival and possible prognostic factors of a group of patients diagnosed with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) hospitalized at the tertiary Rheumatology Centre in Vilnius.
Material and Methods. A cross-sectional study of 27 patients hospitalized at the Rheumatology Centre of Santaros klinikos of Vilnius University Hospital from 1 January 2001 to 31 December 2015 with diagnoses of GPA and MPA were carried out. Data on demographics, clinical characteristics, laboratory data, and the Birmingham Vasculitis Activity Score were collected.
Results. Seven (25.9%) patients during the onset of the disease received only oral glucocorticoids and 20 (74.1%) patients took additional medication. The BVAS median was 7 (minimum [min] – 2; maximum [max] – 23). The age median was 52 years (min – 12; max – 75). The overall mortality rate was 18.5%. Mean survival time was 126.6 months (95% confidence interval [CI] = 104.5 to 148.6) limited to 154.6 months for the longest-surviving patient.
Conclusions. Life expectancy during past 15 years for AAV patients increased from 99.4 to 126.6 months. A high BVAS score at the onset of the disease is a bad prognostic factor related to shorter life expectancy. The growth of Staphylococcus aureus from nasopharynx might be associated with higher mortality rates and relapses in AAV patients.
Anaesthetic challenges in cancer patients: current therapies and pain management
Authors: Gudaitytė Jūratė , Dvylys Dominykas , Šimeliūnaitė Indrė 
Published: July 2017

The objective. The aim is to present the major effects of cancer treatment (chemotherapy, radiotherapy, surgery) that the anaesthesiologist should consider preoperatively, and to review techniques of the analgesic management of the disease.
Materials and Methods. To summarize the major challenges that cancer patients present for the anaesthesiologists, a literature review was conducted. Articles presenting evidence or reviewing the possible effects of anaesthetics on cancer cells were also included. Online databases of Science Direct, PubMed, and ELSEVIER, as well as reference lists of included studies were searched. Articles published from 2005 to 2016 were selected.
Results. Anaesthesiologists should pay attention to patients receiving chemotherapy and its side effects on organ systems. Bleomycin causes pulmonary damage, anthracyclines are cardiotoxic, and platinum-based chemotherapy agents are nephrotoxic. A lot of chemotherapy agents lead to abnormal liver function, vomiting, diarrhoea, etc. Surgery itself is suspected to be associated with an increased risk of metastasis and recurrence of cancer. Regional anaesthesia and general anaesthesia with propofol should be used and volatile agents should be avoided to prevent cancer patients from perioperative immunosuppression that leads to increased risk of cancer recurrence. Pain management for palliative patients remains a major problem.
Conclusions. To provide the best treatment for cancer patients, cooperation of anaesthesiologists with oncologists and surgeons becomes imperative. It has been established that anaesthetic techniques and drugs could minimize the perioperative inflammation. However, further research of the perioperative “onco-anaesthetic” is needed.
La recherche collaborative en éducation et formation. Instrument ou enjeu éthique de la recherche ?
Authors: ASLOUM Nina , GUY Daniel 
Published: July 2017

Dans le domaine des sciences de l’éducation, les auteurs étudient la place accordée à l’idée de collaboration pour éclairer les processus de coproduction et régulation des pratiques de conduite et d’accompagnement du changement, plus particulièrement quand ces dernières sont soutenues par des recherches-interventions. En appui sur l’analyse d’un ouvrage collectif consacré à la conduite et à l’accompagnement du changement, les auteurs situent l’idée de collaboration dans l’élaboration théorique de l’objet« conduite et accompagnement du changement »et précisent sa place et son rôle dans les modalités de recherche-intervention mises en oeuvre.
La double vraisemblance au fondement de la collaboration de recherche : retour sur la démarche de coconstruction d’un projet entrepreneurial à l’école primaire
Authors: PEPIN Matthias , DESGAGNÉ Serge 
Published: July 2017

Nous proposons dans cet article une analyse de la collaboration entre une enseignante et un chercheur dans le cadre d’une recherche doctorale visant à documenter l’apprentissage à s’entreprendre d’élèves du primaire à l’appui d’un projet de magasin scolaire. Le concept de « double vraisemblance » est convoqué en tant qu’il permet de jeter un regard analytique éclairant sur la démarche de collaboration de recherche. Trois moments de négociation des points de vue des partenaires sont plus spécifiquement analysés comme révélateurs des enjeux à la fois respectifs et communs qui les mobilisent dans la construction de la double vraisemblance du projet de magasin, au bénéfice de l’apprentissage à s’entreprendre des élèves.
Transition from global to local control of dayside reconnection from ionospheric‐sourced mass loading
Authors: Zhang B. , Brambles O. J. , Cassak P. A. , Ouellette J. E. , Wiltberger M. , Lotko W. , Lyon J. G. 
Published: July 2017

AbstractWe have conducted a series of controlled numerical simulations to investigate the response of dayside reconnection to idealized, ionosphere‐sourced mass loading processes to determine whether they affect the integrated dayside reconnection rate. Our simulation results show that the coupled solar wind‐magnetosphere system may exhibit both local and global control behaviors depending on the amount of mass loading. With a small amount of mass loading, the changes in local reconnection rate affects magnetosheath properties only weakly and the geoeffective length in the upstream solar wind is essentially unchanged, resulting in the same integrated dayside reconnection rate. With a large amount of mass loading, however, the magnetosheath properties and the geoeffective length are significantly affected by slowing down the local reconnection rate, resulting in an increase of the magnetic pressure in the magnetosheath, with a significant reduction in the geoeffective length in the upstream solar wind and in the integrated dayside reconnection rate. In this controlled simulation setup, the behavior of dayside reconnection potential is determined by the role of the enhanced magnetic pressure in the magnetospheath due to magnetospheric mass loading. The reconnection potential starts to decrease significantly when the enhanced magnetic pressure alters the thickness of the magnetosheath.
How plume‐ridge interaction shapes the crustal thickness pattern of the Réunion hotspot track
Authors: Bredow Eva , Steinberger Bernhard , Gassmöller Rene , Dannberg Juliane 
Published: July 2017

AbstractThe Réunion mantle plume has shaped a large area of the Earth's surface over the past 65 million years: from the Deccan Traps in India along the hotspot track comprising the island chains of the Laccadives, Maldives, and Chagos Bank on the Indian plate and the Mascarene Plateau on the African plate up to the currently active volcanism at La Réunion Island. This study addresses the question how the Réunion plume, especially in interaction with the Central Indian Ridge, created the complex crustal thickness pattern of the hotspot track. For this purpose, the mantle convection code ASPECT was used to design three‐dimensional numerical models, which consider the specific location of the plume underneath moving plates and surrounded by large‐scale mantle flow. The results show the crustal thickness pattern produced by the plume, which altogether agrees well with topographic maps. Especially two features are consistently reproduced by the models: the distinctive gap in the hotspot track between the Maldives and Chagos is created by the combination of the ridge geometry and plume‐ridge interaction; and the Rodrigues Ridge, a narrow crustal structure which connects the hotspot track and the Central Indian Ridge, appears as the surface expression of a long‐distance sublithospheric flow channel. This study therefore provides further insight how small‐scale surface features are generated by the complex interplay between mantle and lithospheric processes.
Ultra‐Fast Control of Magnetic Relaxation in a Periodically Driven Hubbard Model
Authors: Mendoza‐Arenas Juan Jose , Gómez‐Ruiz Fernando Javier , Eckstein Martin , Jaksch Dieter , Clark Stephen R. 
Published: July 2017

AbstractMotivated by cold atom and ultra‐fast pump‐probe experiments we study the melting of long‐range antiferromagnetic order of a perfect Néel state in a periodically driven repulsive Hubbard model. The dynamics is calculated for a Bethe lattice in infinite dimensions with non‐equilibrium dynamical mean‐field theory. In the absence of driving melting proceeds differently depending on the quench of the interactions to hopping ratio from the atomic limit. For decay occurs due to mobile charge‐excitations transferring energy to the spin sector, while for it is governed by the dynamics of residual quasi‐particles. Here we explore the rich effects that strong periodic driving has on this relaxation process spanning three frequency ω regimes: (i) high‐frequency , (ii) resonant with integer l, and (iii) in‐gap away from resonance. In case (i) we can quickly switch the decay from quasi‐particle to charge‐excitation mechanism through the suppression of ν0. For (ii) the interaction can be engineered, even allowing an effective regime to be reached, giving the reverse switch from a charge‐excitation to quasi‐particle decay mechanism. For (iii) the exchange interaction can be controlled with little effect on the decay. By combining these regimes we show how periodic driving could be a potential pathway for controlling magnetism in antiferromagnetic materials. Finally, our numerical results demonstrate the accuracy and applicability of matrix product state techniques to the Hamiltonian DMFT impurity problem subjected to strong periodic driving.
Expression of the Major Vault Protein (MVP) and Cellular Vault Particles in Fish
Authors: Margiotta Alyssa L. , Bain Lisa J. , Rice Charles D. 
Published: July 2017

ABSTRACTCellular vaults are ubiquitous 13 mega Da multi‐subunit ribonuceloprotein particles that may have a role in nucleocytoplasmic transport. Seventy percent of the vault's mass consists of a ≈100 kDa protein, the major vault protein (MVP). In humans, a drug resistance‐associated protein, originally identified as lung resistance protein in metastatic lung cancer, was ultimately shown to be the previously described MVP. In this study, a partial MVP sequence was cloned from channel catfish. Recombinant MVP (rMVP) was used to generate a monoclonal antibody that recognizes full length protein in distantly related fish species, as well as mice. MVP is expressed in fish spleen, liver, anterior kidney, renal kidney, and gills, with a consistent expression in epithelial cells, macrophages, or endothelium at the interface of the tissue and environment or vasculature. We show that vaults are distributed throughout cells of fish lymphoid cells, with nuclear and plasma membrane aggregations in some cells. Protein expression studies were extended to liver neoplastic lesions in Atlantic killifish collected in situ at the Atlantic Wood USA‐EPA superfund site on the southern branch of the Elizabeth River, VA. MVP is highly expressed in these lesions, with intense staining at the nuclear membrane, similar to what is known about MVP expression in human liver neoplasia. Additionally, MVP mRNA expression was quantified in channel catfish ovarian cell line following treatment with different classes of pharmacological agents. Notably, mRNA expression is induced by ethidium bromide, which damages DNA. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:1981–1992, 2017. © 2017 Wiley Periodicals, Inc.
Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures
Authors: Huang Zhuangrong , Lee Dong‐Yup , Yoon Seongkyu 
Published: July 2017

AbstractChinese hamster ovary (CHO) cells have been widely used for producing many recombinant therapeutic proteins. Constraint‐based modeling, such as flux balance analysis (FBA) and metabolic flux analysis (MFA), has been developing rapidly for the quantification of intracellular metabolic flux distribution at a systematic level. Such methods would produce detailed maps of flows through metabolic networks, which contribute significantly to better understanding of metabolism in cells. Although these approaches have been extensively established in microbial systems, their application to mammalian cells is sparse. This review brings together the recent development of constraint‐based models and their applications in CHO cells. The further development of constraint‐based modeling approaches driven by multi‐omics datasets is discussed, and a framework of potential modeling application in cell culture engineering is proposed. Improved cell culture system understanding will enable robust developments in cell line and bioprocess engineering thus accelerating consistent process quality control in biopharmaceutical manufacturing.
Impact of chronic kidney disease on the diuretic response of tolvaptan in acute decompensated heart failure
Authors: Ikeda Shuntaro , Ohshima Kiyotaka , Miyazaki Shigehiro , Kadota Hisaki , Shimizu Hideaki , Ogimoto Akiyoshi , Hamada Mareomi 
Published: July 2017

AbstractAimThis study investigated the relationship between the initial diuretic response to tolvaptan and clinical predictors for tolvaptan responders in patients with acute decompensated heart failure (ADHF).Methods and resultsPatients (153) with ADHF (clinical scenario 2 or 3 with signs of fluid retention) who were administered tolvaptan were enrolled. Tolvaptan (15 or 7.5 mg) was administered for at least 7 days to those patients in whom fluid retention was observed even after standard treatment. The maximum urine volume immediately after tolvaptan administration showed good correlations with the ejection fraction and estimated glomerular filtration rate that were independent predictors of the urine volume (UV) responders (≥1500 mL increase in urine volume). The diuretic response (in terms of maximum diuresis) diminished with advancing chronic kidney disease (CKD) stage and concomitant deterioration of the renal function. Furthermore, advanced CKD was a significant negative predictor for the body weight (BW) responders (2.0% decrease in the body weight within 1 week after starting tolvaptan). As compared with non‐CKD, the presence of advanced CKD predicts poor diuretic response for both UV and BW responders.ConclusionsThe diuretic response following tolvaptan administration gradually diminished with progressive deterioration of the CKD stage. Worsening renal function was not observed. Tolvaptan is effective in treating CS2 or CS3 ADHF patients who present fluid retention and congestion, suggesting its potential efficacy for fluid management in the ADHF patients with CKD without worsening the renal function.
Neurostimulation as a promising epilepsy therapy
Authors: Lin Yicong , Wang Yuping 
Published: July 2017

SummaryThe revolution in theory, swift technological developments, and invention of new devices have driven tremendous progress in neurostimulation as a third‐line treatment for epilepsy. Over the past decades, neurostimulation took its place in the field of epilepsy as an advanced treatment technique and opened up a new world. Numerous animal studies have proven the physical efficacy of stimulation of the brain and peripheral nerves. Based on this optimistic fundamental research, new advanced techniques are being explored in clinical practice. Over the past century, drawing on the benefits brought about by vagus nerve stimulation for the treatment of epilepsy, various new neurostimulation modalities have been developed to control seizures. Clinical studies including case reports, case series, and clinical trials have been booming in the past several years. This article gives a comprehensive review of most of these clinical studies. In addition to highlighting the advantages of neurostimulation for the treatment of epilepsy, concerns with this modality and future development directions are also discussed. The biggest advantage of neurostimulation over pharmacological treatments for epilepsy is the modulation of the epilepsy network by delivering stimuli at a specific target or the “hub.” Conversely, however, a lack of knowledge of epilepsy networks and the mechanisms of neurostimulation may hinder further development. Therefore, theoretical research on the mechanism of epileptogenesis and epilepsy networks is needed in the future. Within the multiple modalities of neuromodulation, the final choice should be made after full discussion with a multidisciplinary team at a presurgical conference. Furthermore, the establishment of a neurostimulation system with standardized parameters and rigorous guidelines is another important issue. To achieve this goal, a worldwide collaboration of epilepsy centers is also suggested in the future.
Potential biotechnological capabilities of cultivable mycobiota from carwash effluents
Authors: Sibanda Timothy , Selvarajan Ramganesh , Tekere Memory , Nyoni Hlengilizwe , Meddows‐Taylor Stephen 
Published: July 2017

AbstractUrban life has created man‐made extreme environments like carwashes. These environments have, however, not been sufficiently explored for mycobiota that can be sources of biotechnologically useful products, as has been the case with natural extreme environments. Using a combination of culture and molecular techniques, fungi from carwash effluents was characterized for production of lipase and cellulase enzymes, nonpolar and polar biotechnologically relevant secondary metabolites and hydrocarbon utilization. The isolated fungal strains belonged to the genera Alternaria, Cladosporium, Penicillium, Peyronellaea, Rhizopus, Spegazzinia, Trichoderma, Ulocladium and Yarrowia. Sixty‐six percent (66%) of the fungal isolates were found to be able to metabolize naphthalene and benzanthracene, showing potential for application in bioremediation of hydrocarbon polluted sites. Lipase production by the isolates Penicillium sp. BPS3 (2.61 U/ml), Trichoderma sp. BPS9 (2.01 U/ml), Rhizopus sp. CAL1 (2.05 U/ml), Penicillium sp. PCW1 (2.99 U/ml) and Penicillium sp. SAS1 (2.16 U/ml) compared well with previously recorded lipase production levels by other fungi. The highest producers of cellulase were Penicillium sp. SAS1 (12.10 U/ml), Peyronella sp. CAW5 (4.49 U/ml) and Cladosporium sp. SAS3 (4.07 U/ml), although these activities were lower than previously reported levels. GC‐MS analysis of the fungal secondary metabolites resulted in identification of 572 compounds, including azulene, methanamine, N‐pentylidene, metoclopramide, and mepivacaine while compounds determined by UHPLC‐MS included 10‐undecen‐1‐ol, piquerol A, 10‐undecyn‐1‐ol, cyclo(leucylprolyl) and rac‐etomidate. These compounds were previously determined to have various activities including anticancer, antibacterial, antifungal, antihypertensive, antidiabetic and anti‐inflammatory properties. The study demonstrated that fungi from carwash effluents are natural sources of some biotechnologically important products.
A method to measure the absorbed dose of the thyroid during I‐131 therapy, using a collar detector system and a SPECT acquisition
Authors: van Gils Koen , Brinks Peter , Lavalaye Jules , Verberne Hein J. , Habraken Jan B. A. 
Published: July 2017

PurposeDue to variations in biological half‐life, accurate thyroid dosimetry for I‐131 therapy is not trivial in clinical practice. In recent publications, systems are described to measure the uptake of I‐131 in the thyroid repeatedly over time. In this work, we present a method to calculate patient specific pharmacokinetics and absorbed dose using such a collar detector system (CoTI) in combination with a SPECT acquisition and a two‐compartment model fit.MethodsFor three patients receiving I‐131 therapy for benign thyroid conditions, the complete uptake profile is measured over a period of 15 to 25 days after administration. A SPECT measurement is performed to assess the functional volume of the thyroid and the amount of I‐131 in the thyroid. The uptake profile measured in counts‐per‐second is converted to absolute activity in MBq using the absolute quantification of the SPECT. A two‐compartment model is used as a fit to the uptake data of the thyroid and to estimate the activity in the blood‐pool. The estimated absorbed dose to the thyroid is then calculated from the integral of the activity. The assessed parameters from the method (6‐ and 24‐h uptake, thyroid volume and I‐131 uptake concentration) are compared with the values as determined in clinical practice. Furthermore, the convergence of the calculated absorbed dose as a function of measurement series duration is determined to assess the required measurement duration of the uptake profile.ResultsThe two‐compartment model fit shows a good agreement with the measured data points. Resulting dynamic uptake profiles of the three patients differ from each other. The uptake percentages differ from the pretherapy I‐123 uptake measurements that are used in usual clinical practice, which shows the potential added value of the proposed method. The duration of the required measurement series appears to be patient dependent and therefore needs to be determined for each patient individually. The proposed method allows for a basic investigation of the individual dynamic uptake profile of I‐131 in the thyroid and the calculation of the absorbed dose.ConclusionsThe proposed measurement method is feasible and easily implementable given a system that can measure the uptake of I‐131 in the thyroid repeatedly over time. The observed differences in dynamic uptake profiles and the differences in the absorbed thyroid dose as calculated with our method and the parameters of the usual clinical care support the relevance of the proposed method. In future studies, this approach may possibly be used for outcome prediction and therapeutic activity optimization.