bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First US Clinical Experience With Computer-Assisted Propofol Sedation: A Retrospective Observational Comparative Study on Efficacy, Safety, Efficiency, and Endoscopist and Patient Satisfaction
Authors: Lin Otto S. , Kozarek Richard A. , Tombs Deborah , La Selva Danielle , Weigel Wade , Beecher Ryan , Jensen Ana , Gluck Michael , Ross Andrew 
Published: March 2017

BACKGROUND:
Computer-assisted propofol sedation (CAPS) is now approved for moderate sedation of American Society of Anesthesiologists (ASA) class I and II patients undergoing routine endoscopy. As the first US medical center to adopt CAPS for routine clinical use, we compared patient and endoscopist satisfaction with CAPS versus midazolam and fentanyl (MF) sedation.

METHODS:
Patients who underwent elective outpatient upper endoscopy and colonoscopy with CAPS were compared with concurrent patients sedated with MF. The primary end points were patient satisfaction (measured by the validated Patient Sedation Satisfaction Index [PSSI]), and endoscopist satisfaction (Clinician Sedation Satisfaction Index [CSSI]). Secondary end points included procedural success rates, polyp detection rates, adverse events, and procedure/recovery times. Multivariable regression was used for comparative analysis.

RESULTS:
CAPS was utilized to sedate 244 patients, of whom 55 underwent upper endoscopy, 173 colonoscopy, and 16 double procedures. During the same period, 75 upper endoscopies, 223 colonoscopies, and 30 doubles were performed with MF on similar patients. For upper endoscopy, the procedural success rate was 98.2% for CAPS versus 98.7% for MF (P = .96), whereas for colonoscopy, the success rate was 98.9% vs 98.8% (P = .59). Colonoscopic polyp detection rate was 54.5% for CAPS and 59.3% for MF (P = .67). Procedure times were similar between CAPS and MF. For CAPS, the mean recovery time was 26.4 vs 39.1 minutes for MF (P < .001). One CAPS patient required mask ventilation, 4 experienced asymptomatic hypotension or desaturation, and 5 experienced marked agitation resulting from undersedation. For MF, 5 patients had hypotension or desaturation, and 8 experienced undersedation. For colonoscopy, the CAPS group had higher PSSI scores for sedation adequacy, the recovery process and global satisfaction, and higher CSSI scores for ease of sedation administration, the recovery process and global satisfaction. For upper endoscopy and doubles, the CAPS CSSI score was higher for the recovery process only. All P values were adjusted for confounding by using regression analysis.

CONCLUSIONS:
In low-risk patients, CAPS appears to be effective and efficient. CAPS is associated with higher satisfaction than MF for colonoscopies and, to a lesser extent, upper endoscopies.
Do-Not-Resuscitate Status Is Associated With Increased Mortality But Not Morbidity
Authors: Walsh Elisa C. , Brovman Ethan Y. , Bader Angela M. , Urman Richard D. 
Published: March 2017

BACKGROUND:
Do-not-resuscitate (DNR) orders instruct medical personnel to forego cardiopulmonary resuscitation in the event of cardiopulmonary arrest, but they do not preclude surgical management. Several studies have reported that DNR status is an independent predictor of 30-day mortality; however, the etiology of increased mortality remains unclear. We hypothesized that DNR patients would demonstrate increased postoperative mortality, but not morbidity, relative to non-DNR patients undergoing the same procedures.

METHODS:
Using the American College of Surgeons National Surgical Quality Improvement Program database for 2007–2013, we performed a retrospective analysis to compare DNR and non-DNR cohorts matched by the most common procedures performed in DNR patients. We employed univariable and multivariable logistic regression to characterize patterns of care in the perioperative period as well as identify independent risk factors for increased mortality and assess for the presence of “failure to rescue.”

RESULTS:
The most common procedures performed on DNR patients were emergent and centered on immediate symptom relief. When adjusting for preoperative factors, DNR patients were still found to have increased incidence of postoperative mortality (odds ratio 2.54 [2.29–2.82], P < .001) but not postoperative morbidity at 30 days. In addition, cardiopulmonary resuscitative measures and unplanned intubation were found to be less frequent in the DNR cohort.

CONCLUSIONS:
These findings suggest that increased mortality is the result of adherence to goals of care rather than “failure to rescue.”
Effects of a Lidocaine-Loaded Poloxamer/Alginate/CaCl2 Mixture on Postoperative Pain and Adhesion in a Rat Model of Incisional Pain
Authors: Choi Geun Joo , Kang Hyun , Hong Min Eui , Shin Hwa Yong , Baek Chong Wha , Jung Yong Hun , Lee Younsuk , Kim Jeong Wook , Park IL Kyu , Cho Wan Jin 
Published: March 2017

BACKGROUND:
Pain and adhesion are problematic issues after surgery. Lidocaine has analgesics and anti-inflammatory properties, and poloxamer/alginate/CaCl2 (PACM) is a known antiadhesive agent. We hypothesized that the novel combination of lidocaine as chemical barrier and PACM as physical barrier would be beneficial for both postoperative pain and adhesion. The purpose of this study was to investigate the effects of lidocaine-loaded PACM in a rat model of incisional pain. Primary outcome was to evaluate between-group differences for the mechanical withdrawal threshold (MWT) measured by von Frey filament in various concentrations of lidocaine-loaded PACM applied, PACM applied, and sham-operated groups.

METHODS:
Male Sprague-Dawley rats were used for the postoperative pain model. After plantar incision and adhesion formation, 0.5%, 1%, 2%, and 4% lidocaine-loaded PACM, PACM only, nothing, and 4% lidocaine only were applied at the incision site in groups PL0.5, PL1, PL2, PL4, P, S, and L4, respectively. MWT using a von Frey filament and serum levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and high-sensitivity C-reactive protein were measured. Rats were euthanized 2 weeks after surgery, and inflammation and fibrosis were assessed with microscopy. Data were analyzed using the Kruskal–Wallis test, multivariate analysis of variance, and linear mixed-effect model. To compare MWT at each time point, analysis of variance with Bonferroni correction was used.

RESULTS:
Multivariate analysis of variance showed that 4% lidocaine-loaded PACM significantly raised the MWT up to 6 and 8 hours after surgery compared with lidocaine-unloaded groups S and P, respectively; 2% lidocaine-loaded PACM significantly increased the MWT at 4 hours after surgery compared with groups S and C. Linear mixed-effect model showed that the MWT (estimated difference in means [95% confidence interval]) was significantly increased in groups PL2 and PL4 (6.58 [2.52–10.63], P = .002; 11.46 [7.40–15.51], P < .001, respectively) compared with group P. Inflammation and fibrosis seen on microscopic evaluation were significantly decreased in groups PL2 and PL4 compared with group S. Four percent of lidocaine only showed a significant reduction in inflammation. Serum levels of tumor necrosis factor-α, IL-1β, IL-6, and high-sensitivity C-reactive protein were decreased in lidocaine-loaded groups compared with group S or P at 1, 2, and 48 hours, and 2 weeks after surgery, respectively.

CONCLUSIONS:
Lidocaine-loaded PACM reduced postoperative pain, and lidocaine strengthened the antiadhesive effect of PACM.
Existence and asymptotic behavior of standing waves of the nonlinear Helmholtz equation in the plane
Authors: Evéquoz Gilles 
Published: March 2017

Abstract
In this paper we study the semilinear elliptic problem

-

Δ
⁢
u

-

k
2

⁢
u

=

Q
⁢

|
u
|

p
-
2

⁢
u

in
⁢

ℝ
2

,

-\Delta u-k^{2}u=Q|u|^{p-2}u\quad\text{in }\mathbb{R}^{2},

where

k
>
0

{k>0}

,

p
≥
6

{p\geq 6}

and Q is a bounded function.
We prove the existence of real-valued

W

2
,
p

{W^{2,p}}

-solutions,
both for decaying and for periodic coefficient Q.
In addition, a nonlinear far-field relation is derived for these solutions.
The Regularizing Effect of Lower Order Terms in Elliptic Problems Involving Hardy Potential
Authors: Adimurthi A. , Boccardo Lucio , Cirmi G. Rita , Orsina Luigi 
Published: March 2017

Abstract
We study existence and summability of solutions for elliptic problems with a power-like lower order term and a Hardy potential.We prove that, due to the presence of the lower order term, solutions exist and are more summable under weaker assumptions than those needed for the existence without it.
Kazhdan projections, random walks and ergodic theorems
Authors: Druţu Cornelia , Nowak Piotr W. 
Published: March 2017

AbstractIn this paper we investigate generalizations of Kazhdan’s property (T) to the setting of uniformly convex Banach spaces. We explain the interplay between the existence of spectral gaps and that of Kazhdan projections. Our methods employ Markov operators associated to a random walk on the group, for which we provide new norm estimates and convergence results. This construction exhibits useful properties and flexibility, and allows to view Kazhdan projections in Banach spaces as natural objects associated to random walks on groups.We give a number of applications of these results. In particular, we address several open questions. We give a direct comparison of properties (TE) and FEwith Lafforgue’s reinforced Banach property (T); we obtain shrinking target theorems for orbits of Kazhdan groups; finally, answering a question of Willett and Yu we construct non-compact ghost projections for warped cones. In this last case we conjecture that such warped cones provide counterexamples to the coarse Baum–Connes conjecture.
Addressing Technology Uncertainties in Battery Energy Storage Sizing Procedures
Authors: Carpinelli Guido , Mottola Fabio , Proto Daniela 
Published: March 2017

Abstract
This paper analyzes the influence of technology uncertainties on the sizing of battery systems. The sizing is based on the minimization of the costs incurred by the end customer and is performed considering demand response applications in the frame of time of use tariffs. The randomness of i) battery round trip efficiency, ii) life time duration, iii) unit costs related to battery capacity, power conversion system, operation and maintenance and replacement is taken into account in order to identify the most convenient solution from an economic and technical point of view. Based on the load requests of actual industrial and residential loads, numerical applications have been performed. The results provided useful information regarding the influence uncertainties have in the choice of a battery energy storage system.
Could the start of the German recession 2008–2009 have been foreseen? Evidence from Real-Time Data
Authors: Heilemann Ullrich , Schnorr-Bäcker Susanne 
Published: March 2017

AbstractThe Great Recession in Germany was noticed only seven months after its onset. This study examines whether the available data could have helped to predict or identify the crisis in real time. After assessing the accuracy of previous recession forecasts, we examine that of forecasts published from April to December 2008 by twelve major national and international forecast institutions and confront them with real-time data from official statistics, major surveys, and indicators. While annual forecasts for 2008 were unusually accurate due to errors of semi-annual forecasts offsetting each other, forecasters failed to observe the onset of the recession in Q2 2008, although from May onward an increasing amount of data indicated that the economy was in recession or was likely about to enter one. Though the data were neither ambiguous nor misleading, forecasters recognised the onset of the recession as late as mid-November, but also failed to warn of a coming recession. The most convincing explanations for these failures to recognize the crisis in time appear to have been the ‘truth effect’ and forecasters’ ‘low priors about the likelihood of a recession’.
Managing irritable bowel syndrome: The impact of micro-physiotherapy
Authors: Grosjean Daniel , Benini Patrice , Carayon Pierre 
Published: March 2017

Abstract

Background
Irritable bowel syndrome (IBS) has a complex pathology, high prevalence and large impact on patients’ quality of life. As conventional therapy may yield unsatisfactory results, a more holistic approach may be desirable. The current study assessed the effect of micro-physiotherapy on the severity of IBS symptoms.

Methods
In a double-blind study, 61 recurrent IBS patients were randomised to two sessions of micro-physiotherapy or sham micro-physiotherapy. Inclusion criteria were the presence of ≥1 IBS symptom from abdominal pain, constipation, diarrhoea or bloating. Exclusion criteria were previous major intestinal surgery and the presence of chronic diseases. The mean patient age was 53.5±15.3 years. Micro-physiotherapy consisted of micro-palpatory examination to identify osteopathic lesions, followed by micro-massage to stimulate self-healing. The control group underwent a sham procedure. The presence and severity of symptoms was assessed at baseline and at 1-month follow-up by the same gastroenterologist.

Results
Two patients did not complete the study. There was a significant difference in percentage of patients that improved after the first session, at 74 % for the micro-physiotherapy group and 38 % for the sham group, respectively (p=0.005). After the second session, the initial improvement was maintained in both groups, although with no further gains, and the differences between the study groups remained significant (p=0.007).

Conclusions
Micro-physiotherapy significantly improves IBS symptoms and should be explored further for use in mainstream healthcare.
ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29
Authors: Sumalatha Kodandaram , Gowda Mohan , Meenakshisundaram Sreepriya 
Published: March 2017

Abstract

Background
Embelin is a benzoquinone reported to possess anticancer activity in several in vivo and in vitro models of carcinogenesis, especially hematopoietic and prostate malignancy. A detailed investigation on the influence of embelin on epithelial malignancy model system, especially colon adenocarcinoma, is lacking. The objective of the current study is to investigate the antiproliferative, antiinvasive and proapoptotic potential of embelin on colon adenocarcinoma cell line HT-29.

Methods
The effect of embelin (35 µg/mL for 24 h) on cell proliferation was assessed by Sulforhodamine B assay and bromodeoxyuridine incorporation test, antiinvasive effect by Boyden chamber assay and scratch assay. Proapoptotic effects of embelin were determined by studies on DNA fragmentation, annexin V-FITC labeling, TUNEL assay, COMET assay and assay of caspase-3 activity. Influence of embelin on the expression of genes regulating apoptosis (caspase 3 and 9, Bcl-2, Bax, cytochrome C and X-linked inhibitor of apoptosis protein) and migration/invasion (matrix metalloproteinase [MMP]-2 and MMP-9) was investigated by reverse transcription polymerase chain reaction (PCR). Further, the effect of embelin on the levels of reactive oxygen species (ROS), lipid peroxides, nitric oxide, mitochondrial membrane potential and antioxidant status (total reduced glutathione [GSH] and GSH-S-transferase) was evaluated.

Results
Results implicated that embelin treatment inhibited proliferation (IC50 35 µg/mL), induced DNA fragmentation, phosphatidyl serine externalization, increased caspase expression, decreased cell migration and expression of MMPs in HT-29 cells. Interestingly, embelin exhibited prooxidant effect on HT-29 cells and induced excessive ROS generation resulting in apoptotic cell death.

Conclusions
To conclude, embelin treatment could be a promising strategy for the chemotherapy of colon cancer.
Language ideologies on English as a Lingua Franca in Brazil: conflicting positions expressed by undergraduate students
Authors: Carréra Szundy Paula Tatianne 
Published: March 2017

Abstract
Drawing on the concept of ideology proposed by Voloshinov (1929 [1999], Marxismo e filosofia da linguagem: Problemas fundamentais do método sociológico na ciência da linguagem. Trad. Michel Lahud; Yara Frateschi Vieira 9 ed. São Paulo: Editora Hucitec.) and on the notion of language ideology (Woolard 1998, Introduction. In Bambi B. Schieffelin, Kathryn A. Woolard & Paul V. Kroskrity (eds.), Language ideologies practice and theory, 3–47. Oxford: Oxford University Press; Kroskrity 2004, Language ideologies. In Alessandro Duranti (ed.), A companion to linguistic anthropology, 496–517. Blackwell Publishing), this paper addresses language ideologies expressed by participants of an Academic Writing course taught to undergraduate students majoring in English and Portuguese in a public university in Rio de Janeiro, Brazil. The data from which participants’ language ideologies are interpreted come from two literacy events that integrate a wider set of literacy practices (Street 2000, Literacy events and literacy practices. In Marilyn Martin-Jones & Kathryn E. Jones (eds.), Multilingual literacies: Comparative perspectives on research and practice, 17–29. Amsterdam: John Benjamin’s, Street 2009, Ethnography of writing and reading. In David R. Olson & Nancy Torrance (eds.), The Cambridge handbook of literacy, 329–345. Cambridge: Cambridge University Press) in which participants engaged in Moodle, the virtual learning environment of the course. Concerning students’ positions, the analysis depicts how they entextualize ELF scholars’ language ideologies to either (re/de)construct their own standard native-based language ideology about English or to reinforce this same ideology. The paper also examines the stance adopted by the professor in her responses to students’ writings in terms of both her ideological alignment with theories that challenge the role of the native speaker as English expands worldwide and her resistance to naïve and romantic views of this expansion.
Communication courtesy or condescension? Linguistic accommodation of native to non-native speakers of English
Authors: Drljača Margić Branka 
Published: March 2017

AbstractThis paper draws on the perception of English as a lingua franca (ELF) as an activity, rather than a variety, whereby speakers of different lingua-cultural backgrounds respond to the needs of the immediate communicative environment. Such dynamic and context-related nature of ELF involves collaboration and accommodative behaviour of all interlocutors. As the main focus of research on ELF has been interaction predominantly among non-native speakers of English, the present study investigates how native English speakers behave in ELF interaction, that is, whether/how they accommodate their English and what their stance is towards linguistic accommodation. Responses were collected by means of an online questionnaire, yielding 377 respondents in total, who report making adjustments when communicating with non-native speakers, most frequently by enunciating clearly, using fewer idioms and speaking more slowly. The main reasons native speakers give for adjusting their language are promoting mutual intelligibility, showing courtesy and helping the interlocutor hone their English language skills. A fifth of the respondents, however, worry that accommodation might prevent the improvement of non-native speakers’ English proficiency, be perceived as being patronising, and reduce the quality of conversation.
Association of miR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease
Authors: Ghaffarzadeh Maryam , Ghaedi Hamid , Alipoor Behnam , Omrani Mir Davood , Kazerouni Faranak , Shanaki Mehrnoosh , Labbaf Afsaneh , Pashaiefar Hossein , Rahimipour Ali 
Published: March 2017

SummaryBackground:Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP rs2292832 and the risk of CAD in an Iranian population.Methods:Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls).Results:Our analysis revealed that the TT genotype was more frequent in CAD patients than control subjects (P=0.02) implying that TT genotype should be considered as a risk factor in CAD development (TT vs. TC+CC p=0.02, OR=1.88).Conclusions:The present study suggests that rs2292832-TT in pre-miR-149 is associated with CAD in an Iranian population.
Clinical features of girls with short stature among inv (9), Turner (45, X) and control individuals
Authors: Chen Xuefeng , Wang Xiumin , Dong Guanping , Fu Junfen , Wu Wei , Jiang Youjun 
Published: March 2017

AbstractBackground:The clinical significance of pericentric inversion of chromosome 9 [inv (9)] remains unclear.Methods:This case control study assessed girls with short stature. According to karyotypes, the subjects were divided into inv (9) [46,XX,inv (9)(p12q13) and 46,XX,inv (9)(p11q13)], Turner syndrome (45, X) and control (normal 46, XX) groups, respectively. Detailed clinical features were compared.Results:Height standard deviation score (SDS) values at diagnosis were −2.51±0.58, −3.71±2.12 and −2.5±1.24 for inv (9), (45, X) and control groups, respectively (p=0.022). The inv (9) group showed lower body mass index (BMI) values compared with the (45, X) and control groups (F=5.097, p=0.008). Similar growth hormone deficiency (GHD) incidences were found in all groups. Interestingly, height SDS was positively correlated with mother height and patient BMI SDS (r=0.51, p=0.036; r=0.576, p=0.023, respectively) in the inv (9) group. In the (45, X) group, height SDS was positively correlated with birth weight (r=0.392, p=0.039).Conclusions:Short stature in inv (9) girls was correlated with low birth weight (LBW) and mother height.
Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance
Authors: Milenković Svetlana J. , Mirković Ljiljana B. , Jovandarić Miljana Z. , Milenković Dušan M. , Banković Violeta V. , Janković Borisav Z. 
Published: March 2017

AbstractBackground:Insulin resistance (IR) in adults has been associated with intrauterine growth restriction (IUGR). Leptin and adiponectin correlations with anthropometric parameters and IR at 72 h in discordant twins were tested.Methods:We included 24 discordant (birth weight discordance ≥20% in relation to the heavier cotwin) and 30 concordant (birth weight discordance ≤10%) twins.Results:A correlation between leptin (but not adiponectin) level and birth weight (BW), birth length and head circumference in IUGR twins was recorded (p<0.05). Insulin sensitivity (IS) and homeostatic model assessment (HOMA)-IR in IUGR twins were similar to appropriate-for-gestational-age cotwins and unrelated to adipokines. In IUGR twins, adiponectin and insulin associated positively. In larger concordant twins’ leptin level correlated with HOMA-IR and insulin.Conclusions:Leptin, but not adiponectin, levels correlate positively with anthropometric parameters in IUGR twins. IR in IUGR twins is unrelated to adipokines in the first few days of life.