bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosimetric Comparison of Accelerated Partial Breast Irradiation Techniques: Multicatheter Interstitial Brachytherapy and Conformal External Beam Radiotherapy
Authors: Bryantseva Zh. V. , Akulova I. A. , Yaganova T. S. , Ulrikh D. G. , Tabagua T. T. , Krivorotko P. V. , Novikov S. N. 
Published: September 2024

Purpose: To compare dosimetric plans obtained in patients with breast cancer (BC) that underwent accelerated partial breast irradiation (APBI) by conformal external beam radiotherapy (EBRT) or interstitial high dose rate brachytherapy (HDRB).Material and methods: From 2017 to 2022 APBI was performed in 210 patients with stage I–II BC (рТ1N0M0–pT2N0M0). APBI was delivered to the tumor bed: in 99 cases — by EBRT, in another 111 patients — by HDRB. Leﬅ breast was irradiated in 101 women: in 51 women using HDRB, in 50 patients — by EBRT. Following dosimetric parameters were used for comparison of the dosimetric plans: Dmax – maximum dose in the organ at risk; Dmed – mean dose in the organ at risk (heart, leﬅ main coronary artery and its descending branch, ipsilateral lung, breast, skin and subcutaneous tissues).Results: When the tumor bed was irradiated by HDRB, in comparison with EBRT, Dmax for the skin and subcutaneous tissue decreases from 98.4 % to 68.7 %, р < 0.002. The use of HDRB made it possible to reduce the radiation load on the ipsilateral lung: Dmax decreased from 71.9 % to 42.7 % , р < 0.002; Dmed was 5.5 % for HDRB and 2.9 % for EBRT, р > 0.05. On the contrary EBRT associated with higher dose to the breast Dmed breast — 46 % in comparison with HDRB Dmed breast — 16.5 % , р < 0.002. Dose to the heart was higher with HDBT Dmax heart — 20.2 %, Dmed heart was 4.9 % than with EBRT Dmax heart — 14.4 %, Dmed heart — 0.8 %. Dose to the left coronary artery with HDRB Dmax — 6.5 % , Dmed — 3.9 % was higher than with EBRT Dmax — 3.3 % , Dmed — 1.3 % . Dose to the descending branch of the left coronary artery was higher with HDRB Dmax — 12.6 % , Dmed — 9.3 % than with EBRT Dmax — 8.9 % and Dmed — 3.4 % . But this differences were non-significant (р > 0.05).Conclusions. APBI by HDRB associated by significant reduction of the radiation dose to the ipsilateral breast lung, breast, skin and subcutaneous tissues.
Intra-Arterial Chemotherapy for Locally Advanced Oral Cavity Cancer
Authors: Vyzhigina B. B. , Kropotov M. A. , Dolgushin B. I. , Safarov D. A. , Pogrebnyakov I. V. , Alieva S. B. 
Published: September 2024

Introduction: The standard treatment for locally advanced oral cavity cancer is surgery with followed by chemoradiotherapy Surgical treatment carries serious external and aesthetic risks and a long period of rehabilitation. On the other hand, standard chemoradiation treatment does not achieve adequate results. Intra-arterial chemotherapy is a promising treatment option. This method allows targeting the tumor to be while minimizing systemic factors and organ preservation, and the quality of life of the patients.Purpose: To compare the results of treatment of patients with locally advanced oral cancer using induction intra-arterial chemotherapy and surgical treatment at the first step.Material and methods: 62 patients were treated from 2017 to 2023 with locally advanced oral cancer. 23 patients underwent induction chemotherapy according to the DCF regimen with intra-arterial administration of cisplatin and docetaxel. In the second group, 39 patients underwent combined treatment with surgical treatment at the first step. The primary endpoint of the study was overall and disease-free survival. Secondary — objective response, treatment toxicity and the occurrence of prognostic factors in the intra-arterial chemotherapy group.Results: The duration of follow-up of patients in the intra-arterial group was 20.37 (CI 13.23–25.87) and in the surgery group 32.6 (CI 17.1–43.6) months. 1-year overall survival (OS) in the intra-arterial group and in the surgical group was 84.1 % and 69.2 % (p = 0.582), relapse-free survival (RFS) — 77.9 % and 62.5 % (p = 0.944). A subgroup analysis revealed an improvement in OS in patients treated with one arterial basin (p = 0.005). 1-year OS aﬅer induction chemotherapy for complete response, partial response, and stabilization were 90.9, 67.5, and 0 % (p < 0.001), respectively. 1-year RFS for complete response, partial response, and stabilization were 80, 76.2, and 0 % (p < 0.000), respectively.Conclusions: Intra-arterial chemotherapy has equivalent eﬃcacy in terms of survival in patients with locally advanced tumors, oral cavity conclusion is indicated.
Computed tomography-based multi-organ radiomics nomogram model for predicting the risk of esophagogastric variceal bleeding in cirrhosis
Authors: Peng Yu-Jie , Liu Xin , Liu Ying , Tang Xue , Zhao Qi-Peng , Du Yong 
Published: September 2024

BACKGROUND
Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated complications. However, most current studies predict the risk of esophageal variceal bleeding (EVB) based on image features at a single level, which results in incomplete data. Few studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to cirrhosis.
AIM
To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with cirrhosis.
METHODS
In this study, 208 patients with cirrhosis were retrospectively evaluated and randomly split into training (n = 145) and validation (n = 63) cohorts. Three areas were chosen as regions of interest for extraction of multi-organ radiomic features: The whole liver, whole spleen, and lower esophagus–gastric fundus region. In the training cohort, radiomic score (Rad-score) was created by screening radiomic features using the inter-observer and intra-observer correlation coefficients and the least absolute shrinkage and selection operator method. Independent clinical risk factors were selected using multivariate logistic regression analyses. The radiomic features and clinical risk variables were combined to create a new radiomics-clinical model (RC model). The established models were validated using the validation cohort.
RESULTS
The RC model yielded the best predictive performance and accurately predicted the EVB risk of patients with cirrhosis. Ascites, portal vein thrombosis, and plasma prothrombin time were identified as independent clinical risk factors. The area under the receiver operating characteristic curve (AUC) values for the RC model, Rad-score (liver + spleen + esophagus), Rad-score (liver), Rad-score (spleen), Rad-score (esophagus), and clinical model in the training cohort were 0.951, 0.930, 0.801, 0.831, 0.864, and 0.727, respectively. The corresponding AUC values in the validation cohort were 0.930, 0.886, 0.763, 0.792, 0.857, and 0.692.
CONCLUSION
In patients with cirrhosis, combined multi-organ radiomics and clinical model can be used to non-invasively predict the probability of the first secondary EVB.
Liver transplantation following two conversions in a patient with huge hepatocellular carcinoma and portal vein invasion: A case report
Authors: Liang Li-Cong , Huang Wen-Sou , Guo Zhao-Xiong , You Hong-Ji , Guo Yong-Jian , Cai Ming-Yue , Lin Li-Teng , Wang Guo-Ying , Zhu Kang-Shun 
Published: September 2024

BACKGROUND
Surgical resection and liver transplantation (LT) are the most effective curative options for hepatocellular carcinoma (HCC). However, few patients with huge HCC (> 10 cm in diameter), especially those with portal vein tumor thrombus (PVTT), can receive these treatments. Selective internal radiation therapy (SIRT) can be used as a conversion therapy for them because it has the dual benefit of shrinking tumors and increasing residual hepatic volume. However, in patients with huge HCC, high lung absorbed dose often prevents them from receiving SIRT.
CASE SUMMARY
A 35-year-old man was admitted because of emaciation and pain in the hepatic region for about 1 month. The computed tomography scan showed a 20.2 cm × 19.8 cm tumor located in the right lobe–left medial lobes with right portal vein and right hepatic vein invasion. After the pathological type of HCC was confirmed by biopsy, two conversions were presented. The first one was drug-eluting bead transarterial chemoembolization plus hepatic arterial infusion chemotherapy and lenvatinib and sintilimab, converted to SIRT, and the second one was sequential SIRT with continued systemic treatment. The tumor size significantly decreased from 20.2 cm × 19.8 cm to 16.2 cm × 13.8 cm, then sequentially to 7.8 cm × 6.8 cm. In the meantime, the ratio of spared volume to total liver volume increased gradually from 34.4% to 55.7%, then to 62.9%. Furthermore, there was visualization of the portal vein, indicating regression of the tumor thrombus. Finally, owing to the new tumor in the left lateral lobe, the patient underwent LT instead of resection without major complications.
CONCLUSION
Patients with inoperable huge HCC with PVTT could be converted to SIRT first and accept surgery sequentially.
Post Marketing evaluation of Anti Snake Venom (ASV) administered as a standard treatment for snakebite. Experience from western India
Authors: Patel Dhirubhai C , V B Sovani  , Patel N J  
Published: September 2024

Aim: To study the safety profile and effectiveness of Anti Snake venom (ASV) in western India
Methods: This retrospective study gathered safety, epidemiological and clinical data on 157 snake bite patients admitted at Shri Sainath Hospital, in Dharampur, Gujarat, from July 2022 to February 2023.
Results: Majority of the bites occurred between August and November. There were 88 males between 5 and 70 yrs. (mean 39.14 yrs.), 69 females between 2 and 70 years (mean 40.32 yrs.). 6 of these were children ranging from 2 to 12 years.134 were agricultural labourers.
120 cases were analysable. 17 had neurotoxicity and 103 had haemotoxicity. Mean (SD) number of vials used was 10.1(6.2), time to discontinue ASV was 3.0(5.2) hours, and duration of hospital stay was 4.5(2.6) days. Patients bitten by saw scaled vipers were discharged early. In Russel’s Viper bites, number of vials used, was higher if the bite to needle time was less than 6 hours
9 patients suffered 24 adverse events, with two possible cases of anaphylaxis. One case had urticaria, itching and tachycardia as a triad. The remaining were isolated events of mild urticaria, itching, tachycardia, hypotension, cough, rigor.
Conclusion: All cases were successfully managed with no fatalities or severe comorbidities. Adverse events were reported in 5.7% cases. Mean of 10.1 vials were needed for control of envenomation, a number much less that national guidelines. The ASV brand used was well tolerated. Patients who were brought late suffered more renal complications
The implication of liquid hemostatic matrices to prevent hemorrhages during stereotactic biopsy of brain tumors
Authors: Rostorguev E. E. , Kuznetsova N. S. , Kavitskiy S. E. , Matevosyan B. V. , Reznik G. A. , Khatyushin V. E. , Kit O. I. 
Published: September 2024

Purpose of the study. Development of a method for preventing hemorrhages during stereotactic biopsy of a brain tumor using liquid hemostatic matrices on the example of the drug "Floseal®".Patients and methods. The target of the biopsy is the most representative area of tumor tissue according to the data of various modalities of MRI neuroimaging, including contrast-enhanced ones. Out of 133 patients, 60 patients with signs of intraoperative bleeding along the biopsy needle cannula were included in the study group. Further, patients with signs of intraoperative bleeding along the cannula of the biopsy needle were divided into 2 subgroups by independent sequential randomization. Control subgroup (n = 45): cases with signs of intraoperative bleeding of varying severity were operated on, according to the standard technique, without the use of the liquid hemostatic drug Floseal®. The main subgroup (n = 15): in case of intraoperative signs of bleeding, the hemostatic fluid drug Floseal® was injected into the area of tumor material removal.Results. In 6.7 % of patients of the control subgroup, the formation of massive intracerebral hemorrhages was noted in the postoperative period. In 53.3 % of the observations of the control subgroup according to X-ray computer examinations of the brain, there were signs of minor hemorrhages at the point of tumor material collection, which did not require repeated surgical interventions. Postoperative hemorrhages after injection of the Floseal® liquid hemostatic matrix into the biopsy needle in the study subgroup were not detected according to neuroimaging X-ray CT.Conclusion. A method of hemostasis has been developed to prevent hemorrhages using liquid hemostatic matrices. If signs of bleeding from the biopsy needle appeare, the introduction of a hemostatic matrix in the volume of 2 ml helps to manage bleeding intraoperatively, as well as to prevent the occurrence of hemorrhage in the early postoperative period.
Cellular, genomic and transcriptomic effects of secondary metabolites of the Hybrid Butterbur on the HeLa cell line
Authors: Zlatnik E. Yu. , Enin Ya. S. , Burov O. N. , Bondarenko E. S. , Sagakyants A. B. , Kutilin D. S. , Dzigunova Yu. V. , Novikova I. A. , Przhedetskiy Yu. V. 
Published: September 2024

Purpose of the study.To evaluate the cellular, genomic (gene copy number) and transcriptomic (gene expression) effects ofP.hybridus(L.) secondary metabolites when they affect the HeLa cell line.Materials and methods.The isolation of secondary metabolites from plant material and its identification were carried out by preparative chromatography. The composition was determined using mass spectrometric analysis, and the final verification of structural formulas was carried out by nuclear magnetic resonance at the Department of Natural Compounds, the Faculty of Chemistry of the Southern Federal University. The subsequent phase of the study was conducted using both cultural and molecular methods. HeLa cells were cultivated under standard conditions in a MEM medium. Once the confluence level was reached 75–80 %, the nutrient medium was replaced with the introduction of the studied compounds (at a concentration of 4 micrograms/ml) and cultivated for 72 hours. Cell mortality was determined using a NanoEnTek JuliFl counter (Korea) in the presence of 0.4 % trypan blue. The assessment of apoptosis following secondary metabolite exposure was conducted on a BD FACSCanto II flow cytometer using the FITC Annexin V Apoptosis Detection Kit I. The level of replication and expression of the genes responsible for apoptosis was assessed by digital droplet PCR (ddPCR).Results.The following compounds were isolated and verified, and were assigned the following sequence numbers to facilitate their use in the experiment: No. 2 – 2,4-dihydroxy-2,5-dimethylfuran-3(2H)-one, No. 3 – 5-(hydroxymethyl) furan-2-carbaldehyde, No. 5.3 – 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde,P. hybridus(L.) At the stage of cell death assessment, it was found that the greatest effect was achieved in the compound under ordinal No. 2. However, the evaluation of the copy number and expression of theCASP8,CASP9,CASP3, BAX, BCL2, TP53, MDM2, CDKN1B, CDK1, CCND1, CCND3, andRB1genes by DD-PCR revealed the presence of apoptosis initiation in tumor cells at the molecular level under the action of compounds No. 2 and No. 5.3 obtained fromP. hybridus(L.).Conclusion.The outcomes were multifeatured. Only compound 2,4-dihydroxy-2,5-dimethylfuran-3(2H)-one exhibited a pronounced cytostatic effect out of all compounds utilized in the experiment. Concurrently, the compound 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde was found to induce an increase in the expression of theCASP3, CASP8, TP53, andBAXgenes.
Changes in the concentration of freely circulating mutant DNA and wild-type DNA of the H3F3А (K27M) gene in the blood and cerebrospinal fluid of children with diffuse midline gliomas during a course of radiation therapy
Authors: Regentova O. S. , Bozhenko V. K. , Kudinova E. A. , Kulinich T. M. , Dzhikiya E. L. , Kaminskiy V. V. , Antonenko F. F. , Parkhomenko R. A. , Zelinskaya N. I. , Sidibe N. , Polushkin P. V. , Shevtsov A. I. , Bliznichenko M. A. , Solodkiy V. A. 
Published: September 2024

Purpose of the study. To study the possibility of detecting freely circulating DNA of the H3F3A (K27M) gene in blood plasma and cerebrospinal fluid in the lumbar spine in children with diffuse midline gliomas (DMG) during a course of radiation therapy (RT).Materials and methods. Molecular genetic studies were carried out by digital PCR. 96 samples of lumbar cerebrospinal fluid and 288 samples of peripheral blood plasma from 96 pediatric patients were analyzed. The concentration of circulating tumor (ctDNA) mutant DNA and wild-type DNA of the H3F3A (K27M) gene was determined in the studied material against the background of a course of RT. Lumbar cerebrospinal fluid sampling was performed once at the beginning of therapy, blood sampling was performed three times: The 1st test before the start of RT, the 2nd against the background of a total dose 10–15 Gy, and the 3rd after the completion of the RT course. Patients are divided into the following groups: patients with stabilization of brain tumor growth during early magnetic resonance (MR) control 3 months after completion of the course of RT; patients with disease progression during the same follow-up period who underwent radiation or chemoradiotherapy.Results. When the disease stabilized after a RT course during treatment, the concentration level of both the mutant variant of ctDNA and wild-type ctDNA significantly decreased in the third blood fraction. The absence of changes or an increase in the concentration of mutant ctDNA and wild-type ctDNA of the H3F3A (K27M) gene by the end of the course of radiation therapy was typical for patients with disease progression in the form of the appearance of metastatic foci in the central nervous system or continued tumor growth. At the same time, the concentration of wild-type DNA of the H3F3A (K27M) gene in the group of patients with progression was higher both in the lumbar cerebrospinal fluid and in the first fraction of blood plasma.Connclusion. Determination of the concentration and dynamics of circulating tumor DNA of the mutant and wild-type of the H3F3A (K27M) gene in blood plasma and lumbar cerebrospinal fluid in children with diffuse median gliomas of the brain during radiation therapy is promising from the point of view of predicting the effectiveness of therapy.
Observation of the Galactic Center PeVatron beyond 100 TeV with HAWC
Authors: Albert A. , Alfaro R. , Alvarez C. , Andrés A. , Arteaga-Velázquez J. C. , Avila Rojas D. , Ayala Solares H. A. , Babu R. , Belmont-Moreno E. , Bernal A. , Caballero-Mora K. S. , Capistrán T. , Carramiñana A. , Casanova S. , Cotti U. , Cotzomi J. , Coutiño de León S. , De la Fuente E. , de León C. , Depaoli D. , Di Lalla N. , Diaz Hernandez R. , Dingus B. L. , DuVernois M. A. , Díaz-Vélez J. C. , Engel K. , Ergin T. , Espinoza C. , Fan K. L. , Fang K. , Fraija N. , Fraija S. , García-González J. A. , Garfias F. , Goksu H. , González M. M. , Goodman J. A. , Groetsch S. , Harding J. P. , Hernández-Cadena S. , Herzog I. , Hinton J. , Huang D. , Hueyotl-Zahuantitla F. , Humensky T. B. , Hüntemeyer P. , Iriarte A. , Kaufmann S. , Kieda D. , Lara A. , Lee W. H. , Lee J. , Vargas H. León , Linnemann J. T. , Longinotti A. L. , Luis-Raya G. , Malone K. , Martinez O. , Martínez-Castro J. , Matthews J. A. , Miranda-Romagnoli P. , Montes J. A. , Morales-Soto J. A. , Moreno E. , Mostafá M. , Najafi M. , Nellen L. , Newbold M. , Nisa M. U. , Noriega-Papaqui R. , Olivera-Nieto L. , Omodei N. , Osorio-Archila M. , Araujo Y. Pérez , Pérez-Pérez E. G. , Rho C. D. , Rosa-González D. , Ruiz-Velasco E. , Salazar H. , Salazar-Gallegos D. , Sandoval A. , Schneider M. , Schwefer G. , Serna-Franco J. , Smith A. J. , Son Y. , Springer R. W. , Tibolla O. , Tollefson K. , Torres I. , Torres-Escobedo R. , Turner R. , Ureña-Mena F. , Varela E. , Wang X. , Wang Z. , Watson I. J. , Willox E. , Wu H. , Yu S. , Yun-Cárcamo S. , Zhou H. 
Published: September 2024

Abstract
We report an observation of ultrahigh-energy (UHE) gamma rays from the Galactic center (GC) region, using 7 yr of data collected by the High-Altitude Water Cherenkov (HAWC) Observatory. The HAWC data are best described as a point-like source (HAWC J1746-2856) with a power-law spectrum (

d
N

/

d
E
=
ϕ

E

/

26

TeV

γ

), where γ = −2.88 ± 0.15stat − 0.1sys and ϕ = 1.5 × 10−15 (TeV cm2 s)−1

±

0.3

stat

−

0.13

sys

+

0.08

sys

extending from 6 to 114 TeV. We find no evidence of a spectral cutoff up to 100 TeV using HAWC data. Two known point-like gamma-ray sources are spatially coincident with the HAWC gamma-ray excess: Sgr A* (HESS J1745-290) and the Arc (HESS J1746-285). We subtract the known flux contribution of these point sources from the measured flux of HAWC J1746-2856 to exclude their contamination and show that the excess observed by HAWC remains significant (>5σ), with the spectrum extending to >100 TeV. Our result supports that these detected UHE gamma rays can originate via hadronic interaction of PeV cosmic-ray protons with the dense ambient gas and confirms the presence of a proton PeVatron at the GC.
Les flibustiers du « Saint-Nicolas »
Authors: Olivié Frantz , Calafat Guillaume 
Published: September 2024

Flibustier Le terme dériverait du néerlandais vrijbuiter et de l’anglais freebooter (« qui fait du butin librement »), ou bien, selon une autre étymologie, de flibot , un navire ventru de petit tonnage surtout utilisé par les Néerlandais. « Flibuste » apparaît en français au xvii e siècle, à la grande époque de la piraterie dans les Caraïbes, et s’impose rapidement pour désigner la nouvelle réalité de la piraterie associative dans le monde atlantique. Forban Apparu dès le Moyen Age, le terme est synonyme de « pirate » au sens de bandit des mers. Il est de plus en plus utilisé comme insulte à partir de la fin du xviii e siècle, après la fin de la piraterie française dans l’Atlantique, pour désigner un homme sans foi ni loi. Charte-partie Contrat qui précise la part de butin attribuée à chaque membre d’équipage, proportionnellement à la hiérarchie, du capitaine au dernier des matelots.
La glorieuse défaite d’Ézéchias, roi de Juda
Authors: Monerie Julien 
Published: September 2024

Assyriens Les habitants du « pays du dieu Assur », la région située de part et d’autre de la vallée du Tigre et sur une partie du piémont du Zagros. Au sens politique, l’Assyrie désigne un empire qui s’est étendu, au début du Ier millénaire av. n. è., à tout le Proche-Orient. Royaume de Juda Royaume israélite couvrant la moitié sud de l’actuelle Cisjordanie, il fut fondé par le roi David vers l’an 1000 av. n. è. Vassalisé par les Assyriens en 732 av. n. è., Juda connut une brève période d’indépendance dans les années 620 av. n. è., avant de passer sous suzeraineté égyptienne, puis babylonienne.