bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgery combined with postoperative 125I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients
Authors: Mao Ming‐hui , Zheng Lei , Wang Xi‐ming , Li Hua , Qin Li‐zheng , Zhang Jie , Han Zheng‐xue , Zhang Jian‐guo 
Published: August 2016

AbstractBackgroundThis retrospective study was undertaken to analyze the effectiveness and safety of surgery combined with postoperative 125I seed brachytherapy in the treatment of mucoepidermoid carcinoma (MEC) of the parotid gland with risk factors in pediatric patients.ProcedureFrom September 2002 to January 2012, 24 patients, ages 5–16 years (mean, 13.2 years; median, 12.3 years), with MEC of the parotid gland were included. Patients with high risk factors received 125I seed brachytherapy (median actuarial D90, 97 Gy) within 4 weeks following surgery. Radioactivity was 18.5–33.3 MBq per seed and the prescription dose was 60–120 Gy. Overall and disease‐free survival rates, local control rate, and distant metastasis were recorded. Radiation‐associated late side effects, including dermatitis, hearing loss, thyroid nodules, and secondary malignancy, were also evaluated.ResultsDuring the follow‐up period of 5–13.4 years (median, 7.2 years), the overall and disease‐free survival rates were all 100%. No patients developed local recurrence, regional/distant metastasis, and no severe radiation‐associated complications including the second malignancy were noted.ConclusionSurgery combined with postoperative 125I seed brachytherapy is effective and safe in the treatment of MEC of the parotid gland in pediatric patients, with no evidence of severe late radiation‐related complications. More patients and longer follow‐up data are still needed to prove the efficacy of 125I brachytherapy.
Molecular aspects of the interaction between Mason—Pfizer monkey virus matrix protein and artificial phospholipid membrane
Authors: Junková P. , Prchal J. , Spiwok V. , Pleskot R. , Kadlec J. , Krásný L. , Hynek R. , Hrabal R. , Ruml T. 
Published: August 2016

ABSTRACTThe Mason–Pfizer monkey virus is a type D retrovirus, which assembles its immature particles in the cytoplasm prior to their transport to the host cell membrane. The association with the membrane is mediated by the N‐terminally myristoylated matrix protein. To reveal the role of particular residues which are involved in the capsid‐membrane interaction, covalent labelling of arginine, lysine and tyrosine residues of the Mason–Pfizer monkey virus matrix protein bound to artificial liposomes containing 95% of phosphatidylcholine and 5% phosphatidylinositol‐(4,5)‐bisphosphate (PI(4,5)P2) was performed. The experimental results were interpreted by multiscale molecular dynamics simulations. The application of these two complementary approaches helped us to reveal that matrix protein specifically recognizes the PI(4,5)P2 molecule by the residues K20, K25, K27, K74, and Y28, while the residues K92 and K93 stabilizes the matrix protein orientation on the membrane by the interaction with another PI(4,5)P2 molecule. Residues K33, K39, K54, Y66, Y67, and K87 appear to be involved in the matrix protein oligomerization. All arginine residues remained accessible during the interaction with liposomes which indicates that they neither contribute to the interaction with membrane nor are involved in protein oligomerization. Proteins 2016; 84:1717–1727. © 2016 Wiley Periodicals, Inc.
Dual mechanism of photoresponse in composite Si–Au nanolayers on crystalline silicon
Authors: Ken Olga , Yavsin Denis , Dementev Peter , Gurevich Sergey , Sreseli Olga 
Published: August 2016

Silicon‐based structures comprised of crystalline silicon substrates and active layers of mixed silicon and gold nanoparticles were fabricated and characterized. Several layer compositions were studied. The investigated structures demonstrate very large spectral sensitivity (more than 10 A W−1) in the wide spectral range (400–1000 nm). Such large sensitivity implies presence of photocurrent amplification. A model which involves dual mechanism of the photoresponse was proposed in order to explain the appearance of the photocurrent amplification in the investigated structures.Spectral sensitivity of the structure with composite layer of Si and Au nanoparticles on Si substrate (Au volume fraction is ∼50%) at reverse bias voltage of −0.4 V.
Direct correlation of microstructure and device performance of liquid phase crystallized Si thin film solar cells on glass
Authors: Kühnapfel Sven , Gall Stefan , Sonntag Paul , Schäfer Norbert , Abou‐Ras Daniel 
Published: August 2016

Si thin films on glass grown by liquid phase crystallization (LPC) exhibit large grains resembling those in multicrystalline Si wafers. The present work gives direct insight into how planar defects in LPC‐Si thin films influence the device performance of the corresponding solar cells by acquiring electron‐backscatter diffraction maps and measuring solar cell parameters on the same identical positions. By this approach, it was possible to demonstrate how low scanning velocities of the laser line during the crystallization lead to lower densities of grain boundaries, to improved charge‐carrier diffusion lengths, and hence to improved device performances.
magnified imageOrientation‐distribution map acquired by electron backscatter diffraction on a Si thin film crystallized via liquid phase crystallization.
Quantifying Submerged Deposited Fine Sediments in Rivers and Streams Using Digital Image Analysis
Authors: Turley M. D. , Bilotta G. S. , Arbociute G. , Chadd R. P. , Extence C. A. , Brazier R. E. 
Published: August 2016

AbstractDeposited fine sediment is an essential component of freshwater ecosystems. Nonetheless, anthropogenic activities can modify natural fine sediment levels, impacting the physical, chemical and biological characteristics of these ecosystems. An ability to quantify deposited fine sediment is critical to understanding its impacts and successfully managing the anthropogenic activities that are responsible for modifying it. One widely used method, the visual estimate technique, relies on subjective estimates of particle size and percentage cover. In this paper, we present two novel alternative approaches, based on non‐automated digital image analysis (DIA), which are designed to reduce the subjectivity of submerged and surficial fine sediment estimates, and provide a verifiable record of the conditions at the time of sampling. The DIA methods were tested across five systematically selected, contrasting temperate stream and river typologies, over three seasons of monitoring. The resultant sediment metrics were strongly, positively correlated with visual estimates (rs = 0.90, and rs = 0.82, p < 0.01), and similarly strongly, but negatively correlated with a sediment‐specific biotic index, suggesting some degree of biological relevance. The DIA technique has the potential to be a valuable tool for application in numerous areas of river research, where a non‐destructive, less subjective and verifiable method is desirable. Copyright ©2016 The Authors River Research and Applications Published by John Wiley & Sons Ltd
Devolving IEEE 802.1X authentication capability to data plane in software‐defined networking (SDN) architecture
Authors: Benzekki Kamal , El Fergougui Abdeslam , El Belrhiti El Alaoui Abdelbaki 
Published: August 2016

AbstractSoftware‐defined networking (SDN) is a relatively new approach in network management that proposes to separate the network control (Control plane) and the forwarding process (Data plane) to optimize the network infrastructure and improve network performance, controllability, manageability and flexibility. However, like every technology, SDN has brought its own new challenges in terms of security and scalability which are very important aspects that should be considered to design and build a resilient architecture in order to meet carrier grade network requirements. In this paper, we propose a secure SDN architecture with IEEE 802.1X port‐based authentication where we also consider the controller's scalability issue by devolving the access control capability to the data plane. In this way, we reduce the high demand and the workload on the SDN controller. Our proposed model presents a novel SDN network architecture and logical network segmentation which provides an optimal and secure network access with low latency. We have implemented and tested our architecture to show its performance (authentication delays). Copyright © 2016 John Wiley & Sons, Ltd.
Interleukin-8, but Not the Related Chemokine CXCL1, Sustains an Autocrine Circuit Necessary for the Properties and Functions of Thyroid Cancer Stem Cells
Authors: Liotti Federica , Collina Francesca , Pone Emanuela , La Sala Lucia , Franco Renato , Prevete Nella , Melillo Rosa Marina 
Published: August 2016

Abstract
Interleukin-8 (IL-8/CXCL8) mediates its biological effects through two receptors, CXCR1 and CXCR2. While CXCR1 recognizes IL-8 and granulocyte chemotactic protein-2, CXCR2 binds to multiple chemokines including IL-8, CXCL1, 2 and 3. Both IL-8 and CXCL1 have been implicated in the neoplastic features of thyroid cancer (TC). Here, we assessed the role of the autocrine circuits sustained by IL-8 and CXCL1 in determining TC stem cell (TC SC) features. Using immunohistochemistry, we found that thyroid epithelial cancerous, but not normal, cells stained positive for IL-8, whose levels correlated with lymph-nodal metastases. We assessed the expression of endogenous IL-8 and CXCL1, by ELISA assays, and of their receptors CXCR1 and CXCR2, by flow cytometry, in a panel of TC cell lines. These molecules were expressed in TC cell lines grown in adherence, and at higher levels also in thyrospheres enriched in stem-like cells. RNA interference demonstrated that IL-8/CXCR1, but not CXCL1/CXCR2, is crucial for the sphere-forming, self-renewal and tumor-initiating ability of TC cells. Accordingly, treatment of TC cells with IL-8, but not with CXCL1, potentiated cell stemness. We identified CD34 as an IL-8-induced gene and as a TC SC marker, since it was overexpressed in thyrospheres compared to adherent cells. Moreover, CD34 is required for the efficient sphere-forming ability and tumorigenicity of TC cells. Our data indicate that IL-8, but not the CXCL1 circuit, is critical for the regulation of TC SCs, and unveils novel potential targets for the therapy of as yet untreatable forms of TC.
Past‐Free[ze] reachability analysis: reaching further with DAG‐directed exhaustive state‐space analysis
Authors: Teodorov Ciprian , Le Roux Luka , Drey Zoé , Dhaussy Philippe 
Published: August 2016

SummaryModel‐checking enables the automated formal verification of software systems through the explicit enumeration of all the reachable states. While this technique has been successfully applied to industrial systems, it suffers from the state‐space explosion problem because of the exponential growth in the number of states with respect to the number of interacting components. In this paper, we present a new reachability analysis algorithm, named Past‐Free[ze], that reduces the state‐space explosion problem by freeing parts of the state‐space from memory. This algorithm relies on the explicit isolation of the acyclic parts of the system before analysis. The parallel composition of these parts drives the reachability analysis, the core of all model‐checkers. During the execution, the past states of the system are freed from memory making room for more future states. To enable counter‐example construction, the past states can be stored on external storage. To show the effectiveness of the approach, the algorithm was implemented in the OBP Observation Engine and was evaluated both on a synthetic benchmark and on realistic case studies from automotive and aerospace domains. The benchmark, composed of 50 test cases, shows that in average, 75% of the state‐space can be dropped from memory thus enabling the exploration of up to 14 times more states than traditional approaches. Moreover, in some cases, the reachability analysis time can be reduced by up to 25%. In realistic settings, the use of Past‐Free[ze] enabled the exploration of a state‐space 4.5 times larger on the automotive case study, where almost 50% of the states are freed from memory. Moreover, this approach offers the possibility of analyzing an arbitrary number of interactions between the environment and the system‐under‐verification; for instance, in the case of the aerospace example, 1000 pilot/system interactions could be analyzed unraveling an 80 GB state‐space using only 10 GB of memory. Copyright © 2016 John Wiley & Sons, Ltd.
User selection scheme with limited feedback processing and outdated CSI in multiuser relay networks
Authors: Bithas Petros , Rontogiannis Athanasios 
Published: August 2016

AbstractA new user selection strategy is investigated and analyzed in a multiuser relaying environment in the presence of co‐channel interference. The proposed selection scheme aims at avoiding unnecessary feedback load processing, in cases where a target threshold, in the received instantaneous signal‐to‐noise ratio, is exceeded. Assuming that perfect channel state information is available, closed‐form lower bound expressions are derived for the cumulative distribution function of the output signal to interference plus noise ratio. Moreover, the impact of outdated channel state information on the system's performance is also investigated. In addition, under the assumption of high signal‐to‐noise ratio conditions, simplified approximated expressions are also provided for the cumulative distribution functions of the output signal to interference plus noise ratio, which are employed to study the outage probability and bit error probability performance of the system. It is shown that with the proposed approach, a significant reduction in feedback load processing is achieved, with only a slight loss in performance. Copyright © 2016 John Wiley & Sons, Ltd.
The Bakri tamponade balloon as an adjunct treatment for refractory postpartum hemorrhage
Authors: Brown Haywood , Okeyo Stephen , Mabeya Hillary , Wilkinson Jeffrey , Schmitt John 
Published: August 2016

AbstractObjectiveTo evaluate the Bakri tamponade balloon as an adjunct treatment for refractory postpartum hemorrhage (PPH).MethodsA prospective observational intervention study was conducted between January 1, 2013, and May 31, 2015, at Great Lakes Hospital and Moi Teaching and Referral Hospital in Kenya. Eligible participants were diagnosed with PPH (blood loss > 500 mL after vaginal or > 1000 mL after cesarean delivery, and/or hemodynamic changes suggestive of excessive blood loss) unresponsive to standard intervention and were treated using the Bakri balloon. Case report forms were completed for all participants. The primary endpoint was the frequency of surgery after use of the Bakri balloon.ResultsAmong 58 patients, postpartum bleeding was controlled without further surgical intervention in 55 (95%). Among the 55 women with uterine atony, the Bakri balloon successful controlled PPH in 52 (95%). Two of the three hysterectomies performed were for continued bleeding after placement of the Bakri tamponade balloon. Four maternal deaths occurred.ConclusionThe Bakri tamponade balloon proved an effective adjunct in the management of refractory PPH.
Visualizing color term differences based on images from the web
Authors: Umezu Nobuyuki , Takahashi Eriho 
Published: August 2016

Abstract
Color terms are used to express light spectrum characteristics captured by human vision, and color naming across languages partition color spaces differently. Such partition differences have been surveyed through several empirical experiments that employ Munsell color chips. We propose a novel visualization method for color terms based on thousands of images collected from query results provided by an image search engines such as Google. A series of experiments was conducted using eight basic color terms in seven languages. Pixel values in the images are counted to form color histograms according to the color pallet used in the world color survey. The visualization results can be summarized as follows: (1) Japanese and Korean color terms have wider distributions in the color space than terms in other languages do and (2) color visualizations for color terms pink and brown are affected by their links to proper nouns.
Highlights Color terms are visualized with 3D histograms on WCS pallet. Color frequencies are assembled automatically from internet images. Red, orange, and yellow have sharp peaks. French pink has several peaks. Pink and brown are affected by their links to proper nouns. English and French colors have smaller distributions than those of Japanese and Korean.
An Unusual Case of Rabies Encephalitis
Authors: Walker Greg , Thiessen Brian , Graeb Doug , Moore G.R. Wayne , Mackenzie Ian R.A. 
Published: August 2016

AbstractHuman rabies encephalitis is rare in Canada, with only five cases reported in the past 30 years. The first and only patient who contracted rabies encephalitis in British Columbia died in 2003. Here we provide the first detailed clinical and pathological description of that case, which had several unusual features, including preexisting immunosuppression, paralytic presentation, prolonged survival, focal lesions on neuroimaging and severe neuropathology with focal necrosis, intense inflammation, and abundant viral inclusion bodies.
Application of multiplex immunoassay technology to investigations of ocular disease
Authors: Jones Valerie Sloane , Wu Jian , Zhu Si-Wei , Huang Ruo-Pan 
Published: August 2016

Eye-derived fluids, including tears, aqueous humour and vitreous humour often contain molecular signatures of ocular disease states. These signatures can be composed of cytokines, chemokines, growth factors, proteases and soluble receptors. However, the small quantities (<10 µl) of these fluids severely limit the detection of these proteins by traditional enzyme-linked immunosorbent assay or Western blot. To maximise the amount of information generated from the analysis of these specimens, many researchers have employed multiplex immunoassay technologies for profiling the expression or modification of multiple proteins from minute sample volumes.
PUBLIC ORDERING OF PRIVATE COERCION: URBAN REDEVELOPMENT AND DEMOCRATIZATION IN SOUTH KOREA
Authors: Porteux Jonson N. , Kim Sunil 
Published: August 2016

AbstractThis study explores collaboration between state actors and non-state specialists in the market for coercion. We focus on the case of forced evictions in South Korea, where violence carried out by private companies has occurred with the implicit, and at times explicit, sanctioning of the state. This level of government–private security cooperation has traditionally been explained by various hypotheses, including arguments about the weak capacity of a state to enforce compliance, trends in the neo-liberal marketization of state power, or as the outcome of a state being captured by the capitalist classes. Documenting the history of urban redevelopment projects and changes in government responses to major protest incidents in Korea, we instead argue that this niche market for private force is an observable implication of a shift in state–society relations in the wake of democratization. This phenomenon is, in effect, a very undemocratic response to democratization, by state elites.
Towards controlled liquid–liquid microextraction
Authors: Lohse Detlef 
Published: August 2016

In a recent paper, Chu & Prosperetti (J. Fluid Mech., vol. 798, 2016, pp. 787–811) calculate the dissolution of a two-component droplet in an immiscible liquid. Here we discuss in what sense their results go much beyond the Epstein–Plesset solution of a dissolving single-component droplet and hitherto used approximations for dissolving multicomponent droplets. We also highlight the relevance of Chu & Prosperetti’s result for liquid–liquid extraction processes for chemical analysis.
Who Opted Out of an Opt-Out Smoking-Cessation Programme for Hospitalised Patients?
Authors: Nahhas Georges J. , Cummings K. Michael , Talbot Vince , Carpenter Matthew J. , Toll Benjamin A. , Warren Graham W. 
Published: August 2016

Introduction: The Medical University of South Carolina (MUSC) hospital implemented an inpatient opt-out smoking-cessation service where smokers received a mandatory smoking-cessation consult and phone follow-up within 1-month post-discharge.Aim: To examine predictors of patients who opted-out of bedside counselling or follow-up phone calls.Methods: Eligible adult cigarette smokers admitted to the MUSC hospital were enrolled in the programme. Opting-out of bedside consult or follow-up calls were assessed separately using log-linear modelling where predictors included patient demographics, length of hospitalisation, insurance type, smoking history, and motivation/confidence to quit.Results: Of the 38,758 admitted patients (February 2014–May 2015), 6,684 reported currently smoking and were automatically referred to bedside-consult. Approximately 26% of smokers made contact with the counselor, most of whom (83%) accepted the consult. Amongst patients eligible for post-discharge follow-up (n = 3485), 49% responded to the calls. Those who opted-out of the bedside-consult were mostly males (RR = 1.29). Those who did not respond to follow-up calls were younger age (RR = 1.33), with Medicaid/no insurance (RR = 1.17), and had not received a bedside consult (RR = 1.32).Conclusions: An opt-out smoking-cessation programme was feasible and acceptable to most patients and was able to reach 65% of eligible smokers; 17% opted-out of bedside counselling; <1% asked to be removed from further phone calls.
The Rupel Clay Member in the Netherlands: towards a comprehensive understanding of its geometry and depositional environment
Authors: Vis Geert-Jan , Verweij Hanneke , Koenen Mariëlle 
Published: August 2016

AbstractThis study presents the 3-D geometry of the Oligocene Rupel Clay Member and a review of its depositional environment based on new and published data. The Rupel Clay Member (RCM) is a clay layer in the Dutch subsurface which is informally known as the Boom Clay. New depth and thickness maps show that the member is present in nearly the whole subsurface of the onshore Netherlands to a depth of about 1500 m. The thickness of the member is variable but rarely exceeds 125 m. We identified three subunits: RCM-U, with a thickness of 15–40 m; RCM-M, with a thickness of 40–90 m; and RCM-L with a thickness of 25–50 m. The Rupel Clay Member is not a homogeneous clay; both vertical and lateral grain-size trends are present. These trends match with general palaeogeographic trends which foresee near-shore facies in the south and southeast of the onshore Netherlands and a more distal setting when moving northward. The three subunits are correlated with global climatic and regional tectonic events, which have mainly affected marginal facies. Faults are known to cut through the clay layer, but have not been mapped. A mismatch of lithostratigraphic nomenclature between the Netherlands and neighbouring countries is present. Part of the solution for this mismatch lies in the proper interpretation of well data in the Netherlands, both on- and offshore.