bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of health technologies for users facing limitations: A scoping review
Authors: König-Klever Emanuele , Bohn Patrícia Raquel , Libânio Cláudia de Souza , Fogliatto Flavio Sanson , Tonetto Leandro Miletto 
Published: September 2024

BACKGROUND Studies reveal healthcare disparities for people with disabilities (PwD) due to various barriers. Digital health offers promise but raises concerns about the digital divide. To address that, health Information and Communication Technologies (ICTs) should follow inclusive design principles for accessibility to all, including PwD. OBJECTIVE We examine the design of ICTs in healthcare to address the needs of people with disabilities. Three research questions guide the study: (i) how health technologies contribute to healthcare accessibility and inclusion; (ii) what the main challenges are in implementing these technologies; (iii) how health ICTs are structured to meet users’ limitations and enhance performance. METHODS Research questions are addressed through a scoping review and critical literature analysis, drawing from seven databases and grey literature. The analysis of research question (iii) uses the accessibility fundamentals recommended by the Web Accessibility Initiative as starting point. RESULTS Our research reveals a predominant focus on the elderly, with cognitive impairment as the most studied limitation, followed by mobility, reach and dexterity, vision, and hearing. CONCLUSIONS We emphasize the need for inclusive design for all health technologies and investigate their potential to improve user and healthcare system performance. We also propose four promising research directions for further investigation.
Efficacy of a self-made tracheostomy oxygen delivery device for oxygen therapy during postoperative anesthesia recovery
Authors: Xiong Yi-Ying , Chen Chao-Yang , Li Xiang , Yue Xin-Xin , Zhao Ze-Yu 
Published: September 2024

BACKGROUND: Patients with tracheotomy are often monitored in the anesthesia recovery room after reoperation. During this period, oxygen therapy is necessary, and the existing tracheostomy oxygen supply device has many defects. OBJECTIVE: To evaluate the efficacy of a self-made tracheostomy oxygen delivery device on oxygen therapy during postoperative anesthesia recovery. METHODS: Patients were randomly divided into two groups, E and C, with 30 patients in each group, and admitted to the post-anesthesia care unit (PACU). Patients in group E received oxygen through a self-made tracheostomy oxygen delivery device, while patients in group C were supplied oxygen through a unilateral nasal cannula. Respiration (R), pulse oximetry (SpO2), and the number of patients on ventilators were recorded at the time of admission (T0) and one hour after admission (T1). Rapid dry blood gas analyses were performed on 0.6 ml samples of arterial blood collected at T0 and T1. RESULTS: Compared to group C, patients in group E had significantly higher arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2), total carbon dioxide (T-CO2), and actual bicarbonate (AB), while arterial partial pressure of carbon dioxide (PaCO2) was significantly reduced ([Formula: see text] 0.01 or [Formula: see text] 0.05). Compared to T0, PaO2 decreased in both groups at T1, PaCO2 decreased in group E, while SaO2, T-CO2, and AB decreased in group C ([Formula: see text] 0.01 or [Formula: see text] 0.05). CONCLUSION: We found that using the self-made tracheostomy oxygen delivery device in postoperative anesthesia recovery had advantages such as a secure connection to the tracheostoma, adjustable oxygen concentration, air filtration, and the ability to switch oxygen supply between the ventilator and humidifier.
Predicting survival in sepsis: The prognostic value of NLR and BAR ratios
Authors: He Xuwei , Lou Tianzheng , Zhang Ning , Zhu Bin , Zeng Danyi , Chen Hua 
Published: September 2024

BACKGROUND: Due to the high-risk nature of sepsis, emergency departments urgently need a simple evaluation method to assess the degree of inflammation and prognosis in sepsis patients, providing a reference for diagnosis and treatment. OBJECTIVE: To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) combined with the blood urea nitrogen-to-serum albumin ratio (BAR) in sepsis. METHODS: A total of 377 sepsis patients admitted to Lishui People’s Hospital from June 2022 to June 2023 were selected as the study subjects. Based on their prognosis, they were divided into a survival group (255 cases) and a death group (82 cases). The clinical data of the two groups were compared. Multivariate logistic analysis was used to identify factors influencing sepsis prognosis, and ROC curve analysis was used to assess the predictive efficacy of NLR, BAR, and their combination. RESULTS: Compared with survivors, non-survivors had higher NLR and BAR, with statistically significant differences ([Formula: see text] 0.05). After adjusting for confounding factors, NLR (OR [Formula: see text] 1.052) and BAR (OR [Formula: see text] 1.095) were found to be independent prognostic factors for sepsis patients (both [Formula: see text] 0.05). The AUC of NLR combined with BAR was 0.798 (95% CI 0.745–0.850, [Formula: see text] 0.05), higher than the AUC of NLR alone (0.776) and BAR alone (0.701). CONCLUSIONS: The combination of NLR and BAR has a high predictive value for the prognosis of sepsis patients. Its simple calculation makes it particularly suitable for use in emergency departments.
Principales dificultades evidenciadas en el lengua oral en niños de 3 a 4 años a través de la prueba del lenguaje oral
Authors: Chaluisa Maiquez Jessica Aracelly , Padilla Álvarez Gisela Catalina 
Published: September 2024

In the present study, the vocabulary level of students from 3 to 4 years of age from the GuillermoVinueza Fiscal School and the Jilgueritos Child Development Center located in the province ofNapo is compared. The method used is of the comparative type of cross- sectional design witha quantitative approach and descriptive scope, the standardized test Oral Language Assessment(ELO) was applied to a total population of 29 children and the level of oral language was compared in relation to auditory discrimination, phonological, syntactic and semantic aspects. The results show insignificant differences in the area of oral language development within all the aspects to be evaluated. It is concluded that language deficiency groups several factors suchas social, family, affective, economic, housing, tics, teacher training that directly affect thisarea.
Anestesia em paciente com doença de Pompe: Relato de caso e revisão de literatura
Authors: Gonçalves Rafaella Guedes , Amorim Jane Auxiliadora , Feitosa Isabela Maria Pereira de S. S. , Oliveira Rodrigo Philippe Alves de Assis Damasceno , Barros Fábio Raniere Angelim , Nascimento Júlia Amorim do 
Published: September 2024

A doença de Pompe é uma enfermidade autossômica recessiva rara. Trata-se de um erro inato do metabolismo, decorrente da deficiência da enzima alfa-glicosidase ácida, que resulta em acúmulo intralisossomal de glicogênio, clinicamente manifestada por fraqueza muscular progressiva. O objetivo desse estudo foi relatar um caso de anestesia em paciente com doença de Pompe e revisar a literatura. Homem, 47 anos, submetido à colecistectomia videolaparoscópica, sob anestesia venosa total. Na avaliação pré-anestésica apresentava ausculta diminuída em bases pulmonares, saturação de oxigênio 96%, atelectasia em pulmão direito, PaO2 74 mmHg e PaCO2 41 mmHg, e distúrbio ventilatório misto grave com capacidade vital forçada 41% do previsto, ARISCAT escore de 31 pontos. No intra-operatório, além da monitorização de rotina, foram monitorizados o bloqueio neuromuscular e a atividade cerebral e profundidade anestésica. Ao final da cirurgia paciente foi extubado com TOF 100% revertido e administração de sugamadex. Instalado BIPAP e encaminhado à unidade de terapia intensiva. Evoluiu sem apresentar sinais clínicos de insuficiência respiratória e recebeu alta hospitalar sem complicações. Em revisão, descrevemos 10 casos de pacientes com doença de Pompe submetidos à cirurgia, seis deles sob anestesia geral: 8/10 mulheres, com 5 meses a 56 anos de vida. Todos com comprometimento de dois ou mais sistemas: 5/10 do aparelho cardiovascular, 8/10 do aparelho respiratório e 7/10 fraqueza muscular generalizada. Esses pacientes necessitam de um preparo pré-operatório envolvendo uma equipe multidisciplinar. O planejamento da anestesia, monitorização e reversão do bloqueio neuromuscular associados aos cuidados perioperatórios são essenciais para um atendimento com qualidade e segurança.
Percepção de indivíduos acerca do impacto da dieta na saúde oral durante o seu processo de envelhecimento
Authors: Silva Amanda Laryssa Alves da , Maia Luciana Maria Silva de Seixas 
Published: September 2024

Introdução: O envelhecimento populacional está ocorrendo de forma acelerada, exigindo ajustes estruturais para atender as necessidades dos idosos. Isto porque este público alvo pode aumentar a demanda por serviços de saúde. Objetivo: Identificar a percepção de adultos e idosos sobre o impacto da dieta na saúde bucal durante o processo de envelhecimento. Métodos: Estudo transversal, descritivo, quantitativo e qualitativo. Foi aplicado um questionário a 30 participantes com idade entre 20 e 70 anos, recrutados na Clínica Integral da Universidade Federal de Pernambuco. A coleta de dados abordou aspectos sociodemográficos, autopercepção, acessibilidade a serviços odontológicos e dietéticos. Resultados: A amostra foi composta adultos e idosos (50% cada). Foi identificado diferenças entre idosos e adultos quanto à autopercepção, principalmente nos hábitos alimentares e na saúde geral. Enquanto 73,3% dos idosos se declararam felizes, apenas 53,3% dos adultos relataram satisfação. A hipertensão foi identificada como a comorbidade mais comum entre os idosos. Conclusão: Existe uma mudança na autopercepção durante o processo de envelhecimento. Idosos tendem a ser mais satisfeitos com relação a sua saúde. Em qualquer faixa etária faz-se necessária maiores divulgações de conhecimentos sobre nutrição e saúde bucal. Dados permitem criar estratégias para intervenções de prevenção na saúde dos indivíduos, possibilitando que o processo de envelhecimento seja mais saudável.
The Influence of Village Funds, Village Development Quality, and SDGs Achievement on Poverty in Sampang Regency
Authors: Awalia Mellysa Nur , Sutikno Sutikno 
Published: September 2024

The paradigm in solving poverty and development problems has always been a crucial discussion among researchers and academics. Poverty is synonymous with lack of income, lack of access to health, low education, and low infrastructure. This is considered a problem in hindering economic growth. This study aims to determine the influence of village funds, the quality of village development, and the achievement of SDGs (quality village education and prosperous healthy villages) on poverty. The research method used is a quantitative method and the type of data used is secondary data taken from the website of BPS Sampang Regency and the Ministry of PDT and Transmigration using cross section data in 2022. The collected data was analyzed using multiple linear regression with variables such as village funds, the building village index (IDM), village education quality, prosperous healthy villages, and poverty. The results of the study found that village funds, the building village index (IDM), and healthy prosperous villages had a significant effect on poverty in Sampang Regency. Meanwhile, quality village education does not have a significant effect on poverty in Sampang Regency.
Influence of different application rates of FGD gypsum and aeolian sand on CO2 and N2O emissions from cotton-capsicum saline-alkali soil
Authors: Chen Yiwei , Luo Fan , Guan Yao , He Xinghong , Wang Jian , Fan Debao , Gao Rui 
Published: September 2024

As two important greenhouse gases in the atmosphere, CO2 and N2O have been paid much attention to their environmental effects. As a large agricultural and population country in the world, agricultural soil is an important source of greenhouse gas emissions. In recent years, unreasonable agricultural measures will make the soil structure deteriorate and lead to the increase of saline-alkali cultivated land area. Therefore, the comprehensive utilization of saline-alkali land has practical significance for agricultural production and ecological environment safety in our country. In this study, the 11th Regiment of Alar City of the First Division of Xinjiang carried out field tests on saline-alkali cultivated land, and improved the saline-alkali cultivated land with desulfurized gypsum and aeolian sand. Six treatments were set up (blank treatment (CK) desulfurized gypsum 15 t/ha (LH), desulfurized gypsum 30 t/ha (LA), desulfurized gypsum 15 t/hamixed application (FL), Aeolian sand 15 t/ha (FH), and Aeolian sand 30 t/ha (FA)). The effects of different treatments on CO2 and N2O emission fluxes in cotton-pepper soil were observed. The results show that: (1) In the growth stage of cotton-pepper, compared with CK, soil moisture increased, and soil ammonium nitrogen decreased; The conductivity increases with the increase of desulphurized gypsum and the decrease of aeolian sand. The results showed that LA treatment had the best water retention effect and FA treatment had the best salt reduction effect. (2) Compared with CK, the cumulative CO2 emission fluxes of cotton soil under different treatments were CK &gt; LH &gt; FL &gt; FH &gt; LA &gt; FA treatment, and those of pepper soil were CK &gt; FL &gt; LH &gt; FH &gt; FA &gt; LA treatment. Among them, the inhibition effect of cumulative soil CO2 emission under LA and FA treatment reached a significant level. (3) Compared with CK, the cumulative N2O emission fluxes of LH, LA, FL, FH and FA treated soil in cotton field were CK &gt; LA &gt; LH &gt; FH &gt; FL &gt; FA, and that of pepper soil was CK &gt; FA &gt; LH &gt; LA &gt; FL &gt; FH. Among them, the inhibition effect of aeolian sand (FA and FH) on soil N2O cumulative emission reached a significant level. (4) Compared with CK, LH, LA, FL, FH and FA treatments reduced the comprehensive greenhouse effect of cotton field and pepper crops by inhibiting soil CO2 emission fluxes, among which FA treatment had the lowest comprehensive greenhouse effect. Therefore, the effects of different treatments on physicochemical properties and gas emissions of saline-alkali soil were comprehensively analyzed, and FA treatment had the best effect on inhibiting CO2 and N2O emissions and improving soil physicochemical properties.
Prognosis of colorectal cancer, prognostic index of immunogenic cell death associated genes in response to immunotherapy, and potential therapeutic effects of ferroptosis inducers
Authors: Lei Mengjie , Xiao Meihua , Long Zhiqing , Lin Taolin , Ding Ran , Quan Qi 
Published: September 2024

IntroductionThis study leverages bioinformatics and medical big data to integrate datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA), providing a comprehensive overview of immunogenic cell death (ICD)-related gene expression in colorectal cancer (CRC). The research aims to elucidate the molecular pathways and gene networks associated with ICD in CRC, with a focus on the therapeutic potential of cell death inducers, including ferroptosis agents, and their implications for precision medicine.MethodsWe conducted differential expression analysis and utilized advanced bioinformatic techniques to analyze ICD-related gene expression in CRC tissues. Unsupervised consensus clustering was applied to categorize CRC patients into distinct ICD-associated subtypes, followed by an in-depth immune microenvironment analysis and single-cell RNA sequencing to investigate immune responses and cell infiltration patterns. Experimental validation was performed to assess the impact of cell death inducers on ICD gene expression and their interaction with ferroptosis inducers in combination with other clinical drugs.ResultsDistinct ICD gene expression profiles were identified in CRC tissues, revealing molecular pathways and intricate gene networks. Unsupervised consensus clustering refined the CRC cohort into unique ICD-associated subtypes, each characterized by distinct clinical and immunological features. Immune microenvironment analysis and single-cell RNA sequencing revealed significant variations in immune responses and cell infiltration patterns across these subtypes. Experimental validation confirmed that cell death inducers directly affect ICD gene expression, highlighting their therapeutic potential. Additionally, combinatorial therapies with ferroptosis inducers and clinical drugs were shown to influence drug sensitivity and resistance in CRC.DiscussionOur findings underscore the importance of ICD-related genes in CRC prognosis and therapeutic targeting. The study provides actionable insights into the efficacy of cell death-inducing therapies, particularly ferroptosis inducers, and their regulatory mechanisms in CRC. These discoveries support the development of precision medicine strategies targeting ICD genes and offer valuable guidance for translating these therapies into clinical practice, with the potential to enhance CRC treatment outcomes and patient survival.
From the shallows to the depths: a new probe set to target ultraconserved elements for Decapoda and other Malacostraca
Authors: Geburzi Jonas C. , Rodríguez-Flores Paula C. , Derkarabetian Shahan , Giribet Gonzalo 
Published: September 2024

IntroductionSince its introduction about a decade ago, target enrichment sequencing of ultraconserved elements (UCEs) has proven to be an invaluable tool for studies across evolutionary scales, and thus employed from population genetics, to historical biogeography as well as deep-time phylogenetics. Here, we present the first probe set targeting UCEs in crustaceans, specifically designed for decapods and tested beyond decapods in other malacostracan lineages.MethodsProbes were designed using published genomes of nine decapod and one peracarid species, as well as raw Nanopore long reads of one additional brachyuran species. The final probe set consists of about 20,000 probes, targeting 1,384 unique UCE loci. We compiled a dataset across Malacostraca,as well as datasets of a deep-sea squat lobster genus, and an intertidal mangrove crab species, to test the probe set at different phylogenetic levels (i.e., class, order, genus, within species).ResultsFinal mean UCE recovery from fresh samples across Malacostraca was 568 loci, with up to 847 and 658 loci recovered from decapod and non-decapod species, respectively. Final mean recovery from fresh samples in the genus- and within species-level datasets was 849 and 787 loci, respectively. Up to several hundreds of UCEs were recovered from historical museum specimens (10 to &gt; 150 years old), that were included in all datasets. UCE-based phylogenies largely reflected the known relationships of the included taxa, and we were able to infer population differentiation based on &gt;600 SNPs extracted from the species-level dataset.DiscussionOur results showcase the versatility of this UCE probe set, yielding informative data from phylogenetic as well as population-genetic datasets. They demonstrate once more that UCEs are a promising technique for leveraging museum specimens for genomic studies, and overall highlight the probe set's potential for crustacean evolutionary studies.
Efficacy and safety of onabotulinumtoxinA in the treatment of medication overuse headache: a systematic review
Authors: Lang Hui , Peng Cheng , Wu Kongyuan , Chen Xiwen , Jiang Xin , He Li , Chen Ning 
Published: September 2024

PurposeMedication overuse headache (MOH) is a chronic headache caused by regular overuse of medications. OnabotulinumtoxinA (BoNTA) is used for preventive treatment of MOH. However, its efficacy and safety remain controversial.MethodsSeven online databases (Cochrane Library, Embase, Medline, PubMed, China National Knowledge Infrastructure, Wanfang data, and Chinese BioMedical Literature Database) were searched for relevant articles published between January 2002 and March 2024. We included randomized controlled trials (RCTs) and cohort studies on the treatment of MOH using BoNTA versus a placebo or other active treatments.ResultsWe retrieved 487 articles in the database search. Of these, four eligible RCTs were identified after detailed screening. A total of 1,259 patients with MOH (622 patients treated with BoNTA, 607 with placebo, and 30 with topiramate) were included in the four RCTs. We found that BoNTA significantly reduced headache frequency compared with placebo (mean difference, 1.89; 95% confidence interval (CI), 1.11–2.67; I2 = 0%; p &lt; 0.001). There was no significant difference between BoNTA and the placebo in terms of secondary outcomes, which included reductions in acute medication intake (MD, 1.30; 95% CI, −1.18–3.78; I2 = 0%; p = 0.30), Migraine Disability Assessment questionnaire scores (MIDAS, MD, −4.04; 95% CI, −29.36–21.28; I2 = 0%; p = 0.75), and Headache Impact Test scores (HIT-6, MD, 0.03; 95% CI, −1.77–1.83; I2 = 0%; p = 0.97). BoNTA was more likely to cause adverse events (OR, 1.87; 95% CI, 1.45–2.42; I2 = 0%; p &lt; 0.001) than placebo.ConclusionThe results of this study show that BoNTA reduces headache frequency and is effective for the treatment of MOH.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022315845.
Associations between vitamin A and K intake and lung function in the general US population: evidence from NHANES 2007–2012
Authors: Chen Yi-Chuan , Hung Ming-Szu 
Published: September 2024

IntroductionWhile nutrition's critical role in enhancing respiratory health is acknowledged, the specific impacts of vitamins A and K on lung function remain largely unexplored. The study aimed to evaluate the relationships between vitamins A and K intake and lung function.MethodsThe cross-sectional study focused on adults aged 20–79 with utilizing data from US National Health and Nutrition Examination Survey (NHANES) 2007–2012. Lung function was assessed by measuring forced expiratory volume (FEV1), forced vital capacity (FVC), and the ratio of these two values (FEV1/FVC). Regression model was performed to determine the associations between intake of vitamins A and K and outcomes.ResultsData of 10,034 participants (representing 142,965,892 adults in the US) were analyzed. After adjusting for relevant confounders, multivariable analysis revealed 1 μg/day increase of vitamin A intake was significantly associated with 0.03 ml increased FEV1 (p = 0.004) and 0.04 ml increased forced vital capacity (FVC) (p &lt; 0.001). In addition, 1 μg/day increase in vitamin K intake was significantly associated with 0.11 ml increased FEV1 (p = 0.022). Neither vitamin A and K intake was associated with FEV1/FVC or presence of airway obstruction.ConclusionsIn relatively healthy population of the US, greater vitamin A or K intake was independently associated with better lung function assessed by spirometry. Benefits of such vitamins for pulmonary health should be confirmed in future randomized controlled trials.