bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crossing the finish line faster when paddling the data lake with KAYAK
Authors: Maccioni Antonio , Torlone Riccardo 
Published: September 2017

Paddling in a data lake is strenuous for a data scientist. Being a loosely-structured collection of raw data with little or no meta-information available, the difficulties of extracting insights from a data lake start from the initial phases of data analysis. Indeed, data preparation, which involves many complex operations (such as source and feature selection, exploratory analysis, data profiling, and data curation), is a long and involved activity for navigating the lake before getting precious insights at the finish line.
In this framework, we demonstrate KAYAK, a framework that supports data preparation in a data lake with ad-hoc primitives and allows data scientists to cross the finish line sooner. KAYAK takes into account the tolerance of the user in waiting for the primitives' results and it uses incremental execution strategies to produce informative previews of these results. The framework is based on a wise management of metadata and on features that limit human intervention, thus scaling smoothly when the data lake evolves.
Arzneimittelversorgung in der Onkologie
Authors: Dengler Robert 
Published: September 2017

Zusammenfassung
Die Arzneimittelversorgung in der Onkologie zeichnet sich durch einige Besonderheiten wie die Verordnung von Rezepturarzneimitteln aus. Neu zugelassene Medikamente beinhalten Biopharmazeutika sowie Proteinkinasehemmer. Die klassischen Rabattverträge für Generika erbringen keine weiteren Einsparungen. Die Möglichkeit, nach AMNOG für patentgeschützte Arzneimittel einen Erstattungsbeitrag zu verhandeln, wird kontinuierlich genutzt. Die Ausschreibung der Zubereitung ist durch das AMVSG wieder entfallen.
RESPONS PERTUMBUHAN DAN KERAGAAN DARAH DARI TIGA STRAIN IKAN NILA TERHADAP PEMBERIAN HORMON PERTUMBUHAN REKOMBINAN IKAN KERAPU KERTANG
Authors: Listiyowati Nunuk , Alimuddin Alimuddin , Sukenda Sukenda , Setyawan Priadi 
Published: September 2017

Berbagai strain ikan nila sudah berhasil dibudidayakan di Indonesia. Penelitian ini dilakukan untuk mengevaluasi penambahan hormon pertumbuhan rekombinan ikan kerapu kertang, Epinephelus lanceolatus (rElGH) dalam pakan terhadap performa pertumbuhan dan imunitas tiga strain ikan nila terhadap infeksi bakteri Streptococcus agalactiae. Tiga strain nila yang digunakan adalah strain nila biru (hasil pemuliaan di Sukamandi), srikandi (toleran salinitas tinggi dari Sukamandi) dan nirwana (hasil pemuliaan di Wanayasa)dengan kisaran rerata bobot 0,24-0,4 g/ekor dan panjang standar 1,9-2,27 cm/ekor. Ikan dipelihara dalam bak fiber bulat kapasitas 1,5 ton air sebanyak sembilan buah selama 50 hari, dengan padat tebar 200 ekor/bak. Pakan mengandung rElGH dosis 2 mg/kg pakan diberikan dua hari sekali, selama dua minggu dengan frekuensi tiga kali sehari (pagi, siang, dan sore) secara at satiation (sampai kenyang). Hasil penelitian menunjukkan ikan yang diberi rElGH memiliki pertumbuhan yang lebih baik dibandingkan kontrol, kecuali nila biru. Pertumbuhan terbaik terdapat pada nila srikandi dengan bobot 6,08 ± 1,26 g; laju pertumbuhan harian 0,12 ± 0,03 g/hari dan panjang standar 5,5 ± 0,63 cm. Ikan nila yang mendapatkan perlakuan rElGH pada pakan menunjukkan ketahanan tubuh yang berbeda ketika diuji tantang dengan bakteri S. agalactiae. Ikan nila nirwana memiliki jumlah kematian yang paling sedikit P<0,05) dibandingkan dengan ikan nila srikandi dan nila biru terhadap infeksi S. agalactiae. Nilai MTD ikan nila nirwana perlakuan rElGH dan kontrol adalah 174,3 jam dan 217,7 jam. Hasil pengamatan uji tantang menunjukkan bahwa tidak ada yang berbeda dalam parameter hematologi. Sebagai kesimpulan, strain ikan nila sangat memengaruhi efektivitas pemberian rElGH dalam memacu pertumbuhan dan imunitasnya.
KERAGAMAN FENOTIPE TRUSS MORFOMETRIK DAN GENOTIPE IKAN GABUS (Channa striata) DARI JAWA BARAT, SUMATERA SELATAN, DAN KALIMANTAN TENGAH
Authors: Kusmini Irin Iriana , Prakoso Vitas Atmadi , Kusdiarti Kusdiarti 
Published: September 2017

Ikan gabus di Indonesia awalnya hanya terdapat di Barat garis Wallace (Sumatera, Jawa, dan Kalimantan) yang kemudian diintroduksi ke Indonesia bagian Timur. Ikan gabus termasuk ke dalam deretan ikan air tawar sebagai sumber daya genetik untuk menunjang diversifikasi usaha budidaya. Guna menyukseskan program diversifikasi tersebut, maka perlu diketahui keragaman genetik ikan gabus dari Jawa Barat, Sumatera Selatan, dan Kalimantan Tengah agar dapat direkomendasikan sebagai dasar pemuliaan. Tujuan penelitian ini untuk menganalisis keragaman dan kekerabatan antara populasi ikan gabus dari Jawa Barat, Sumatera Selatan, dan Kalimantan tengah. Metode penelitian dilakukan dengan analisis fenotipe terhadap 16 ekor ikan sampel dari masing-masing daerah tersebut, sedangkan untuk analisis keragaman genotipe masing-masing digunakan 10 ekor ikan dari setiap daerah. Analisis tersebut dilakukan melalui truss morfometrik dan RAPD dengan primer OPA-10, OPA-11, dan OPA-15. Hasil penelitian menunjukkan keragaman berdasarkan truss morfometrik dan hasil PCR ikan gabus asal Sumatera Selatan lebih tinggi dibandingkan Kalimantan Tengah dan Jawa Barat. Kekerabatan ikan gabus Kalimantan Tengah lebih dekat dengan ikan gabus Sumatera Selatan dibandingkan dengan ikan gabus Jawa Barat. Hasil penelitian ini dapat dijadikan sebagai informasi untuk pertimbangan dalam program pemuliaan.
PENGARUH IMPLANTASI HORMON 17a-METIL TESTOSTERON TERHADAP PEMATANGAN GONAD DAN FERTILITAS SPERMA IKAN BAUNG (Mystus nemurus)
Authors: Sularto Sularto , Dewi Raden Roro Sri Pudji Sinarni , Khasani Ikhsan 
Published: September 2017

Penelitian ini bertujuan untuk mengetahui pengaruh implantasi hormon 17a-metiltestosteron terhadap pematangan gonad dan daya fertilitas sperma ikan baung (Mystus nemurus). Ikan uji yang digunakan adalah calon induk ikan baung jantan dengan kisaran bobot antara 187–338,5 g; panjang 21,1–27,5 cm; berumur 2 tahun dari hasil budidaya. Wadah pemeliharaan berupa waring berukuran 2 m x 2 m x 1,25 m yang ditempatkan dalam kolam tembok berukuran 200 m. Perlakuan adalah implantasi pelet hormon 17a-metiltestosteron dengan dosis: 0 (kontrol) (A), 100 (B), 200 (C), 300 (D), dan 400 µg/kg induk (E), setiap perlakuan diulang 4 kali. Hasil percobaan menunjukkan bahwa implantasi pelet hormon 17a-metiltestosteron dapat merangsang pematangan gonad serta meningkatkan produksi sperma ikan baung. Sperma hasil stripping terbukti dapat membuahi telur dengan daya fertilitas masing-masing perlakuan: 27,65% (A); 42,4% (B); 79,0 % (C); 43,95% (D); dan 39,5% (E), dengan daya tetas masing-masing perlakuan: 14,6% (A); 42,2% (B); 69,7 % (C); 43,5% (D); dan 32,5% (E). Dosis 200 µg/kg induk merupakan dosis yang paling efektif untuk pematangan gonad ikan baung jantan
PENGARUHDEWAN DIREKSI, DEWANKOMISARIS INDEPENDEN,LEVERAGE, DAN AKTIVITASPERUSAHAANTERHADAP PENGUNGKAPANSUSTAINABILITYREPORT
Authors: Awalia Eria Nissa , Anggraini Ratna , Prihatni Rida 
Published: September 2017

This research was intended to examine the influences of board of directors, board of independent commissioner, leverage, and activity of company toward sustainability report disclosure. Sustainability Report Disclosure is the dependent variable sinthis research were measured by GRIG 3.1 Content Index and Checklists. For the independent variables in this research, using board of directors were measured by sum of directors meetings, board of in dependent commissioner were measured by proportion of independent commissioner, leverage were measured by debt to equity, activity of company were measured by total asset turnover. This research uses secondary data which is financial statement. and sustainability report from Indonesian Stock Exchange Listed Companies in 2010-2012. While the sampling method used was purposive sampling method which is overall 39 observations. This research uses multiple regression method to test the hypothesis with SPSS computer program. From the analysis performed in this research, it can be concluded that board of directors, and leverage have no significant influence to sustainability report disclosure. The other hand activity of company has positive influence and significant to sustainability report disclosure. And Board of independent commissioner has negative influence and significant to sustainability reporting disclosure.

KeyWords: Board of Directors, Board of Independent Commissioner, Leverage, Activity of Company, and Sustainability Report
PENGARUH SISTEM INFORMASI AKUNTANSI MANAJEMEN, STRATEGI, DAN INOVASI TERHADAP KINERJA OPERASIONAL PERUSAHAAN MANUFAKTUR DALAM MEMASUKI ERA PERDAGANGAN BEBAS
Authors: Prabowo Harry , Jaya Tresno Eka 
Published: September 2017

Tujuan Penulisan ini adalah untuk menganalisa pengaruh analisis variabel independen terhadap variabel dependen. Penelitian dilakukan dengan menggunakan data primer berupa pernyataan kuesioner tentang variabel independen sistem informasi akuntansi manajemen, strategi, dan inovasi terhadap variabel dependen yaitu kinerja operasional perusahaan. Jumlah sampel yang digunakan yaitu 24 perusahaan manufaktur di DKI Jakarta yang dapat dijangkau oleh peneliti, penentuan sampel ini menggunakan teori Gay. Metode analisis yang digunakan adalah regresi linier berganda dengan uji asumsi klasik yang meliputi uji normalitas, uji multikolonieritas, dan uji heterokedastisitas. Hasil Penulisan menunjukan bahwa variabel sistem informasi akuntansi manajemen memiliki pengaruh terhadap kinerja operasional perusahaan, strategi memiliki pengaruh terhadap kinerja operasional perusahaan dan inovasi memiliki pengaruh terhadap kinerja operasional perusahaan.

Kata Kunci : Sistem Informasi Akuntansi Manajemen, Strategi, Inovasi, Kinerja Operasional Perusahaan.
Sorghum and Groundnut Sole and Intercrop Nutrient Response in Semi‐Arid West Africa
Authors: Maman N. , Dicko M. K. , Gonda A. , Wortmann C. S. 
Published: September 2017

Sorghum–groundnut intercropping is agronomically and economically important in West Africa.
Intercrop nutrient response functions are needed to maximize profit from fertilizer use.
Intercrop response functions can be estimated from sole crop responses.
Sorghum (Sorghum bicolor L. Moench)–groundnut (Arachis hypogaea L.) intercropping is important in the Sahel and Sudan Savanna. Nineteen trials were conducted during 2014 and 2015 in Mali and Niger for determination of: response functions for sorghum sole crop (SSC) and intercrop to N, P, and K; effects of the P×N interaction and of a nutrient package for diagnosis of other deficiencies; and a procedure for estimation of intercrop functions from SSC response functions. Six Niger on‐station trials included treatments for determination of intercrop effects on sorghum yield and response. Mean grain and fodder yield increases for SSC were, respectively, 18.8 and 17.6% with 10 kg ha−1 P, 30.7 and 18.8% with 30 kg ha−1 N, and 0 and 6.8% with 10 kg ha−1 K applied. The diagnostic treatment increased grain yield for only 1 of 19 site‐years (SYs). Sorghum grain yield was 30% less with intercropping compared with SSC for 2 of 6 SY but 11% less overall. Overall, sorghum fodder yield was 23% more with intercropping. Sorghum response to P was 86% greater for SSC compared with intercrop. With intercropping, groundnut pod yield exceeded sorghum grain yield. The value of intercrop production was higher than for SSC. Fodder added 23 and 30% to the value of SSC and intercrop harvests, respectively. Equations were developed for determining optimal nutrient rates and intercrop response functions from SSC functions. Fertilizer applied to the intercrop compared with SSC has much more profit potential for this part of West Africa.
PEMIKIRAN GENDER MENURUT PARA AHLI: Telaah atas Pemikiran Amina Wadud Muhsin, Asghar Ali Engineer, dan Mansour Fakih
Authors: Arbain Janu , Azizah Nur , Sari Ika Novita 
Published: September 2017

<p class="IIABSTRAK333">Ajaran agama memiliki potensi dominan dalam penerapan ideologi gender yang bias. Dalam konteks itu pula, agama bisa memberikan inspirasi dan dorongan munculnya ketidakadilan gender. Bagaimana mungkin agama bisa berpotensi menimbulkan ketidakadilan? Tentu saja potensi ketidakadilan itu bukan bersumber dari prinsip agama, melainkan karena proses perkembangan agama yang didominasi oleh budaya patriarkhat. Untuk itu, ajaran agama harus ditinjau kembali dan dianalisis secara krisis, terutama ajaran tentang faktor kodrati atau ilahi dan faktor yang bukan kodrati.Pada dasarnya, setiap agama mengajarkan bahwa manusia diciptakan sama derajatnya, baik laki-laki maupun perempuan. Terdapat beberapa pemikir yang memiliki perhatian besar atas persoalan gender telah mengupas secara teo­retis, dan metodologis, diantaranya Amina Wadud Muhsin, Asghar Ali Engineer, dan Mansour Fakih.</p><div> </div>
A conceptual framework for real time estimation of WFP for small hydroelectric power plant
Authors: Sivapragasam C. , Pallikonda Rajasekaran M. , Vinotha M. 
Published: September 2017

Abstract
It is believed that the power sector, particularly hydroelectric power, contributes to a very high consumption of fresh water in terms of evaporation from storage reservoirs. Robust methods of water footprint (WFP) assessment will eventually help in the pricing of water and energy. Conventionally, WFP for hydropower plants is estimated by dividing the gross/net evaporation losses by power generation. This approach is highly biased when it comes to a small hydropower plant connected to a large reservoir. In this study, a two-pronged subjective–objective method is suggested for a reservoir with primary functions of power generation and downstream water release. The objective part is concerned with giving weight to the evaporation loss proportional to the water use while the subjective part is concerned with refining this by considering the real time reservoir operation conditions and taking into account the recommendations of the decision making authorities. The effect of timescale in WFP analysis is also studied and conclusions are drawn. Thumb rules for WFP estimation are evolved which will aid in such analysis. The implementation of the proposed methodology for any reservoir system is recommended using LabVIEW platform.
Student Response System Technology in Accounting Information Systems Courses
Authors: Newmark Richard , Seaton Lloyd “Pat” , Stallings Matthew 
Published: September 2017

ABSTRACT
Student Response Systems (SRSs), also known as clickers, are posited to increase class participation and enhance active learning. In this study, we evaluate perceived effectiveness and student satisfaction with SRSs in Accounting Information Systems classes over several semesters. We also provide additional analyses to determine how SRSs are used in the classroom and which student characteristics and aspects of the classroom experience appear to be related to perceived satisfaction. We find three factors that explain 58% of the variation in SRS satisfaction. These are learning, environment, and class interaction. Two of these factors (learning and environment) are affected by variation in the way the system is used (participation mode vs. quiz mode), and all three are affected by the gender of the student. We find that gender is not directly related to overall satisfaction. In addition, we propose a model for SRS satisfaction based on our exploratory results.
Magnetic Flux Rope Identification and Characterization from Observationally Driven Solar Coronal Models
Authors: Lowder Chris , Yeates Anthony 
Published: September 2017

Abstract
Formed through magnetic field shearing and reconnection in the solar corona, magnetic flux ropes are structures of twisted magnetic field, threaded along an axis. Their evolution and potential eruption are of great importance for space weather. Here we describe a new methodology for the automated detection of flux ropes in simulated magnetic fields, utilizing field-line helicity. Our Flux Rope Detection and Organization (FRoDO) code, which measures the magnetic flux and helicity content of pre-erupting flux ropes over time, as well as detecting eruptions, is publicly available. As a first demonstration, the code is applied to the output from a time-dependent magnetofrictional model, spanning 1996 June 15–2014 February 10. Over this period, 1561 erupting and 2099 non-erupting magnetic flux ropes are detected, tracked, and characterized. For this particular model data, erupting flux ropes have a mean net helicity magnitude of

Mx2, while non-erupting flux ropes have a significantly lower mean of

Mx2, although there is overlap between the two distributions. Similarly, the mean unsigned magnetic flux for erupting flux ropes is

Mx, significantly higher than the mean value of

Mx for non-erupting ropes. These values for erupting flux ropes are within the broad range expected from observational and theoretical estimates, although the eruption rate in this particular model is lower than that of observed coronal mass ejections. In the future, the FRoDO code will prove to be a valuable tool for assessing the performance of different non-potential coronal simulations and comparing them with observations.
The communicative performance of a severely hearing-impaired adolescent
Authors: Russel Ann 
Published: September 2017

This study describes the communicative performance of a severely hearing-impaired adolescent.The experimenter taught the subject how to play Russian Backgammon. The subject conversed with, and afterwards taught his mother, speech therapist, and a peer how to play the game. Each dyad played the game once. Videotape recordings were made of each dyadic situation. The channels of communication, both verbal and nonverbal, used by each speaker, were determined. A relational communication coding scheme, involving the analysis of requests and subsequent responses, was applied to the data. Results indicate that the hearing-impaired adolescent, though not always able to hold a dominant position in a dyadic situation, was capable of expressing the same types of control as normal adults. Moreover, the types of control expressed varied as a function of each contextual setting. Whenever the subject did hold a dominant position, the combined verbal plus nonverbal channel was his predominant mode of communication. These findings suggest that a sociolinguistic approach provides important information regarding a hearing-impaired adolescent's communicative performance.
The effect of intracranial pressure on the performance of an aphasic subject: A case history
Authors: Shapiro Michelle 
Published: September 2017

A battery of tests involving the language modalities of speech, comprehension, reading and writing were administered to an aphasic subject who presented with a predictable fluctuation in intracranial pressure. Results revealed a consistency in performance in the two situations, across all modalities. The subject's performance was found to be of a concrete nature, demonstrating a cognitive deficit concomitant with his linguistic impairment.
Genome Editing for Cancer Therapy: Delivery of Cas9 Protein/sgRNA Plasmid via a Gold Nanocluster/Lipid Core–Shell Nanocarrier
Authors: Wang Peng , Zhang Lingmin , Xie Yangzhouyun , Wang Nuoxin , Tang Rongbing , Zheng Wenfu , Jiang Xingyu 
Published: September 2017

AbstractThe type II bacterial clustered, regularly interspaced, short palindromic repeats (CRISPR)‐Cas9 (CRISPR‐associated protein) system (CRISPR‐Cas9) is a powerful toolbox for gene‐editing, however, the nonviral delivery of CRISPR‐Cas9 to cells or tissues remains a key challenge. This paper reports a strategy to deliver Cas9 protein and single guide RNA (sgRNA) plasmid by a nanocarrier with a core of gold nanoclusters (GNs) and a shell of lipids. By modifying the GNs with HIV‐1‐transactivator of transcription peptide, the cargo (Cas9/sgRNA) can be delivered into cell nuclei. This strategy is utilized to treat melanoma by designing sgRNA targeting Polo‐like kinase‐1 (Plk1) of the tumor. The nanoparticle (polyethylene glycol‐lipid/GNs/Cas9 protein/sgPlk1 plasmid, LGCP) leads to >70% down‐regulation of Plk1 protein expression of A375 cells in vitro. Moreover, the LGCP suppresses melanoma progress by 75% on mice. Thus, this strategy can deliver protein‐nucleic acid hybrid agents for gene therapy.
Brief Report: A Novel ELANE Mutation Associated With Inflammatory Arthritis, Defective NETosis, and Recurrent Parvovirus Infection
Authors: Thanarajasingam Uma , Jensen Mark A. , Dorschner Jessica M. , Wampler Muskardin Theresa , Ghodke‐Puranik Yogita , Purmalek Monica , Eliopoulos Elias , Zervou Maria I. , Goulielmos George N. , Howard Matthew , Kaplan Mariana J. , Niewold Timothy B. 
Published: September 2017

ObjectiveWe describe a 38‐year‐old woman who presented with a history of inflammatory arthritis, rash, and daily fevers. She was noted to have chronic parvovirus infection with persistently detectable viral titers and a novel mutation in the ELANE gene. ELANE encodes neutrophil elastase, a neutrophil serine protease with important antimicrobial effects, and is found as part of neutrophil extracellular trap (NET) complexes. Pathogenic ELANE mutations have been identified in forms of hereditary neutropenia. However, our patient never had neutropenia. Because of the striking clinical scenario, we investigated this mutation functionally.MethodsNET formation by neutrophils was assessed by scanning electron microscopy. Neutrophil activation and neutrophil elastase production were evaluated by flow cytometry and fluorescent substrate–based functional assay, respectively. A multiplex assay was used to quantitate neutrophil inflammatory cytokine production. PyMOL software was used to generate 3‐dimensional models of mutant elastase.ResultsActivated neutrophils from the patient demonstrated a significantly decreased ability to form NETs on scanning electron microscopy, as well as quantitative defects in neutrophil activation and neutrophil elastase activity. The patient's neutrophils showed altered levels of interleukin‐12 (IL‐12) and IL‐8, which are key cytokines for antiviral immunity and neutrophil chemotaxis. Three‐dimensional mapping revealed that the mutation could alter protein folding and surface charge distribution, potentially perturbing protein trafficking. Thus, the mutation could affect neutrophil function by decreasing NETosis and altering key antiviral activities of neutrophils.ConclusionThis is the first report of a human pathogenic ELANE mutation associated with a defect in NETosis and a distinct syndrome of recurrent viral infection and chronic inflammation.
Phytansäure
Authors: Schönfeld Peter , Reiser Georg 
Published: September 2017

ZusammenfassungAls verzweigtkettige Fettsäure ist die Phytansäure für die tierischen Zellen eine Energiequelle. Die Phytyl‐Kette der Phytansäure ist aber auch ein essentieller Baustein der Membranlipide von extremophilen Bakterien. Phytansäure wird beim Chlorophyllabbau im Wiederkäuermagen gebildet und vom Menschen überwiegend als deren Milch‐ und Fleischprodukte aufgenommen. Der oxidative Abbau der Phytansäure erfolgt durch Peroxisomen und Mitochondrien. Bei erhöhter Gewebekonzentration ist die Phytansäure ein Störfaktor des zellulären Energiestoffwechsels. Phytansäure kann aber auch Auskunft über die Essgewohnheiten der Antike geben.