bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of careHPV, Cervista Human Papillomavirus, and Hybrid Capture 2 Methods in Diagnosing Cervical Intraepithelial Neoplasia Grade 2+ in Xinjiang Uyghur Women
Authors: Tuerxun Gulixian , Yukesaier Awaguli , Lu Ling , Aierken Kailibinuer , Mijiti Patiman , Jiang Yujie , Abulizi Axianguli , Zhang Yuanyuan , Abuduxikuer Guzhanuer , Abulizi Guzhalinuer , Li Hua 
Published: June 2016

Abstract

Objective.
The study aimed to evaluate the value of the Cervista human papillomavirus (HPV), Hybrid Capture 2 (HC-2), and careHPV tests in diagnosing cervical intraepithelial neoplasia grade 2 (CIN2) or worse in Xinjiang Uyghur women.

Methods.
Three high-risk human papillomavirus (HR-HPV) detection methods were studied on two different populations by different combination modes; a cytology specimen was obtained at the same time. An abnormal result of any test resulted in referral to colposcopy. Cervical biopsy was also performed.

Results.
In population 1, HR-HPV-positive rates were 57.6% and 54.3% as detected by HC-2 and Cervista, respectively; κ = 0.892 for consistency check of HC-2 and Cervista (p &lt; .001). Area under the receiver operating characteristic curve (AUC) of HC-2 and Cervista was 0.744 (95% confidence interval [CI]: 0.664∼0.824, p &lt; .001) and 0.786 (95% CI: 0.715∼0.858, p &lt; .001), respectively, for diagnosing CIN2+. The A9 probe can detect six subtypes of HPV, including HPV16, HPV31, HPV33, HPV35, HPV52, and HPV58. If one or more of these subtypes are postitive, then A9 will be positive. A diagnosis of class A9 by the Cerevista test correlated with pathological interpretations (chi-square = 43.063, p &lt; .001). In population 2, HR-HPV-positive rates were 40.1% and 34.4%, respectively, by HC-2 and careHPV; κ value was 0.779 for the two tests (p &lt; .001). AUC of HC-2 was 0.895 (95% CI: 0.849∼0.940, p &lt; .001), and careHPV was 0.841 (95% CI: 0.770∼0.899, p &lt; .001) for diagnosing CIN2+.

Conclusion.
Good consistency was shown between HC-2 and Cervista tests and also between the HC-2 and careHPV tests. In the detection of CIN2+, Cervista showed better specificity than HC-2, and interpretation of the A9 subgroup showed high predicted value. The HC-2 test demonstrated better sensitivity than careHPV in detection of CIN2+. HC-2, Cervista, and careHPV may be applied as a triage test for visual inspection with acetic acid/Lugol’s iodine-positive or ThinPrep cytologic test-positive women. The careHPV test was comparatively economical and efficient and may be more suitable for resource-limited regions, such as Xinjiang.
Developmental Trajectories of Children’s Social Competence in Early Childhood: The Role of the Externalizing Behaviors of Their Preschool Peers
Authors: Yudron Monica , Jones Stephanie M. 
Published: June 2016

The construct of social competence encompasses a set of discrete skills considered important for the formation of positive relationships with others (Raver & Zigler, 1997). Despite the importance of social competence, little is known about its developmental course through early childhood. In addition, little is known about the influence of preschool classroom-level peer characteristics on the developmental trajectory of social competence.In this study, we fit multilevel models of change to explore children’s trajectories of social competence in early childhood. We investigated whether critical features of children’s trajectories differed systematically by observed aggregate differences in the externalizing behaviors of their preschool peers—a salient aspect of one of the first social contexts in which children engage. We found that children’s social competence grows over time in early childhood and has a statistically significant, positive relationship with the classroom level of externalizing behaviors. Evidence of this relationship disappears when the quality of the classroom relational climate is controlled for in the multilevel regression model.
Detection of Root (Wilt) Disease of Coconut (Cocos nucifera L.) based on polyacrylamide gel electrophoresis
Authors: Chaturvedi V. K. , Rajeev G. , Nampoothiri C. K. 
Published: June 2016

<div><p><em>Root (wilt) disease (RWD), caused by phytoplasma, is a major problem causing decreased coconut productivity in southern districts of Kerala and its bordering districts of Tamil Nadu in India. The disease is non-curable but its incidence can be reduced by propagating seedlings from nuts of disease free palms. The disease free palms are selected by ELISA test which uses antiserum obtained from rabbits against purified phytoplasma extract containing 29, 28 and 18.5 K Da proteins. With an objective of developing a simpler and easier biochemical test than ELISA for RWD detection in coconut , direct SDS PAGE profiles of soluble proteins from crude leaf extracts of healthy and diseased palms of West Coast Tall (susceptible) , Chowghat Green Dwarf and Malayan Green Dwarf (high degree resistant) cultivars were evaluated</em> <em>for differences in intensities of protein bands with molecular masses corresponding closest to the purified phytoplasma extract proteins. It was found that the 31.2, 37.3, 16.9 and 13.8 KDa bands in WCT cultivar, 31 and 40.6 KDa in CGD cultivar and 29.9 and 37.1 KDa bands in the MGD cultivar showed consistent differences in intensities and/or presence or absence of certain bands between healthy and diseased palms. Correlations and path analysis relationship between intensity of different protein bands and ELISA value also showed significant association of one or two of these marker bands with ELISA values in each cultivar. The</em> <em>SDS PAGE profiles of crude leaf extracts could be used to effectively distinguish healthy and diseased RWD palms in these three cultivars.</em><strong></strong></p></div>
Prevalence of Traumatic Dental Injuries in Patients Attending University of Alberta Emergency Clinic
Authors: Alkhadra Thamer , Preshing William , El-Bialy Tarek 
Published: June 2016

Objectives:This study evaluated the prevalence of dental trauma for patients attending the emergency dental clinic at the University of Alberta Hospital between 2006-2009. Patients’ examination and treatment charts were reviewed.Methods:Total number of patients’ charts was 1893.The prevalence of different types of trauma was 6.4 % of the total cases (117 patients). Trauma cases were identified according to Ellis classification and as modified by Hollandet al.,1988.Results:Logistic statistical model showed that 21.7% were Ellis class I trauma, 16.7% were Ellis class II trauma, and 6.7% were Ellis class III. In addition, 11.7 % presented with avulsion, 7.5 % presented with dentoalveolar fracture and 7.5% presented with sublaxation. Also, 17.55 % presented with tooth displacement within the alveolar bone, 3.3 % presented with crown fracture with no pulp involvement, 4.16 % presented with crown fracture with pulp involvement and 3.3 % presented with root fracture. In conclusion, the general prevalence of dentoalveolar trauma in patients attending the emergency clinic at the University of Alberta is less than other reported percentages in Canada or other countries.
Peut-on parler de démocratie radicale à Athènes ?
Authors: Brun Patrice , Lafargue Philippe 
Published: June 2016

Résumé La notion de « démocratie radicale », dont on peine à trouver, en grec ancien, l’équivalent, a souvent été comprise comme une déviance d’un régime idéal, pour l’essentiel contemporain de l’époque de Périclès. Pourtant, l’étude serrée des sources littéraires et l’apport des sciences sociales permettent des conclusions bien plus nuancées. Il semble bien que la « démocratie radicale », subversive ou révolutionnaire, assortie de débordements populaires appliquée à l’Athènes classique, soit davantage une projection à la fois idéologique et anachronique, marquée par la crainte du déclin, qu’une réalité.
La construcción de un eje antiateniense en el Mediterráneo a finales del siglo v a.C.: Hermócrates, Lisandro y Darío II
Authors: Gómez Castro Daniel 
Published: June 2016

Résumé Cet article, qui souhaite traiter des relations internationales dans le monde grec à la fin du v e siècle avant J.-C., s’intéresse particulièrement au à démonter comment le projet politique développé par une faction spartiate a agit comme déclencheur de la crise des relations internationales au sein du monde grec. L’histoire de ce projet permet de comprendre les événements du début du iv e siècle. L’accent sera mis sur la campagne militaire de Cyrus le Jeune, la guerre perso-spartiate et la guerre de Corinthe.
L’ équipement de Junon à Lanuvium est quadrifonctionnel
Authors: Meulder Marcel A. J. 
Published: June 2016

L’équipement de la statue de Junon à Lanuvium reflète les quatre fonctions indo-européennes : ses escarpins la troisième, celle de la sexualité féconde, sa lance et son bouclier la deuxième, celle de la guerre, son vêtement la première, celle de la souveraineté. Mais ce vêtement consiste en une peau de chèvre et la déesse est coiffée de cornes de chèvre. La chèvre, comme l’indiquent entre autres les Nones Caprotines et Junon Caprotine, représente la quatrième fonction, celle qui recouvre tout ce qui est marginal à l’ordre, à l’harmonie et à la continuité (la mort, l’exclusion sociale, le désordre, l’inconnu) et le passage vers les autres fonctions. Ceci explique pourquoi de nombreux présages sont liés à la Junon de Lanuvium, la chèvre possédant également un pouvoir de médium. La peau et les cornes de chèvre que porte la Junon de Lanuvium marquent l’intégration de cette quatrième fonction aux autres.
Città siciliane “privilegiate” in epoca repubblicana
Authors: Soraci Cristina 
Published: June 2016

Résumé À l’époque de Cicéron, seules huit cités de Sicile jouissaient de statuts privilégiés ; cette étude vise à rechercher les motivations (parmi lesquelles l’importance stratégique des sites, la fidélité à la cause romaine, les liens de parenté avec l’ Urbs , les mérites propres à ses cités et la force de persuasion de leurs ambassadeurs) qui incitèrent les Romains à favoriser les habitants d’une ville plutôt que d’une autre.
La Layetania interior en época augústea: un ejemplo de reordenación territorial en la Hispania Citerior Tarraconense
Authors: Oller Guzmán Joan 
Published: June 2016

Résumé Cette étude porte sur la Léetanie intérieure adossée à la côte centrale du nord-est de la péninsule Ibérique à l’époque augustéenne. Nous émettons l’hypothèse qu’Auguste s’appuya sur cette région pour restructurer le territoire et y développer une économie d’importance à partir de la via Augusta . Trois grandes transformations vont être entreprises : l’implantation du « système de la civitas » adaptée aux caractéristiques du territoire, une refonte des voies de communication avec la construction de la via Augusta et la création d’un cadastre pour organiser ledit territoire.
Miséricorde et fidélité. Le fait d’Israël dans l’évangile selon saint Matthieu
Authors: Leproux Alexis 
Published: June 2016

L’usage du terme Israël dans l’évangile de Matthieu autorise-t-il à parler de « rejet » des Juifs dans la conception de l’Église, peuple de Dieu ouvert aux nations ? L’article confronte l’originalité narrative du premier évangile aux lectures historiques qui en ont été faites. L’examen des termes Israël, peuple, juif, Église, nation et de Mt 8,11-12 ; 21,43 ; 27,25 permet de comprendre comment la nouveauté du Christ manifeste la fidélité de Dieu envers son peuple : le premier lieu de l’Église est Israël.
Amoris laetitia : discerner à la lumière de la Parole de Dieu
Authors: Calmeyn Marie Laetitia 
Published: June 2016

L’exhortation apostolique Amoris laetitia invite à entrer dans la contemplation de la famille que « la Parole de Dieu met entre les mains de l’homme, de la femme et des enfants » ( AL 29). Cette approche théologale fait cheminer dans une vision réaliste et salutaire des diverses situations familiales : la lecture de l’Écriture, dans ses détours et contradictions, en référence à l’amour du Christ pour son Église, conduit au discernement et à l’accompagnement.
Le nouveau texte de la Commission pontificale pour les relations avec le judaïsme, nœud gordien de la théologie du dialogue ?
Authors: Andrevon Martine-Thérèse 
Published: June 2016

Cet article analyse le récent document de la Commission pontificale pour les relations avec le judaïsme, « Les dons et appels de Dieu sont irrévocables » (10 déc. 2015). Il souligne les orientations nécessaires du dialogue qui découlent de Vatican ii : christologie et unité du salut. Il indique quelques points problématiques : étendue de l’accomplissement et achèvement du salut, christocentrisme et théologie trinitaire, permanence et mission du peuple juif.
Le contrôle migratoire en Croatie
Authors: Dujmovic Morgane 
Published: June 2016

<p class="resume">La frontière est un objet multidimensionnel et multi-scalaire. Observer les contrôles qui s’y opèrent nécessite de mettre en place une méthodologie par à-coups, faite de va-et-vient entre empirie et théorie, et qui s’adapte aux jeux d’échelles et d’acteurs. Comment « saisir » les modalités du contrôle migratoire et comment représenter les variations de l’objet-frontière ? C’est là l’enjeu de ce résumé de poster qui propose, à partir du cas croate, une plongée à la frontière extérieure de l’Union européenne. </p>
Tolerogenic Phenotype of IFN-γ–Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop
Authors: Li Qingsheng , Harden Jamie L. , Anderson Charles D. , Egilmez Nejat K. 
Published: June 2016

Abstract
Previous studies demonstrated that IL-12–driven antitumor activity is short-circuited by a rapid switch in dendritic cell (DC) function from immunogenic to tolerogenic activity. This process was dependent on IFN-γ and the tolerogenic phenotype was conferred by IDO. Extended monitoring of IDO+ DC in the tumor-draining lymph nodes of IL-12 plus GM-CSF–treated tumor-bearing mice revealed that whereas IFN-γ induction was transient, IDO expression in DC was maintained long-term. An in vitro system modeling the IFN-γ–mediated change in DC function was developed to dissect the molecular basis of persistent IDO expression in post–IL-12 DC. Stimulation of DC with IFN-γ and CD40L resulted in rapid induction of IDO1 and IDO2 transcription and recapitulated the in vivo switch from immunogenic to tolerogenic activity. Long-term maintenance of IDO expression was found to be independent of exogenous and autocrine IFN-γ, or the secondary cytokines TGF-β, TNF-α, and IL-6. In contrast, both IDO enzymatic activity and IFN-γ–induced AhR expression were required for continued IDO transcription in vitro and in vivo. Addition of the tryptophan catabolite kynurenine to DC cultures in which IDO activity was blocked restored long-term IDO expression in wild-type DC but not in AhR-deficient DC, establishing the central role of the kynurenine–AhR pathway in maintaining IDO expression in tolerogenic DC. These findings shed further light on the cellular and molecular biology of the post–IL-12 regulatory rebound and provide insight into how feedback inhibitory mechanisms dominate in the long-term.
Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration
Authors: Lo Tsun-Ho , Silveira Pablo A. , Fromm Phillip D. , Verma Nirupama D. , Vu Phi A. , Kupresanin Fiona , Adam Rhonda , Kato Masato , Cogger Victoria C. , Clark Georgina J. , Hart Derek N. J. 
Published: June 2016

Abstract
C-type lectin receptors play important roles in immune cell interactions with the environment. We described CD302 as the simplest, single domain, type I C-type lectin receptor and showed it was expressed mainly on the myeloid phagocytes in human blood. CD302 colocalized with podosomes and lamellopodia structures, so we hypothesized that it played a role in cell adhesion or migration. In this study, we used mouse models to obtain further insights into CD302 expression and its potential immunological function. Mouse CD302 transcripts were, as in humans, highest in the liver, followed by lungs, lymph nodes (LN), spleen, and bone marrow. In liver, CD302 was expressed by hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells. A detailed analysis of CD302 transcription in mouse immune cells revealed highest expression by myeloid cells, particularly macrophages, granulocytes, and myeloid dendritic cells (mDC). Interestingly, 2.5-fold more CD302 was found in migratory compared with resident mDC populations and higher CD302 expression in mouse M1 versus M2 macrophages was also noteworthy. CD302 knockout (CD302KO) mice were generated. Studies on the relevant immune cell populations revealed a decrease in the frequency and numbers of migratory mDC within CD302KO LN compared with wild-type LN. In vitro studies showed CD302KO and wild-type DC had an equivalent capacity to undergo maturation, prime T cells, uptake Ags, and migrate toward the CCL19/CCL21 chemokines. Nevertheless, CD302KO migratory DC exhibited reduced in vivo migration into LN, confirming a functional role for CD302 in mDC migration.
Are platelet indices useful in diagnosis of tropical acute febrile illnesses?
Authors: Viswanathan Stalin , Saravanakumari Vijayakumar 
Published: June 2016

Background: Diagnosis and treatment of tropical acute febrile illnesses is challenging with respect to health facilities and personnel and diagnostic kits. Platelet indices are available at no extra cost or blood requirements. They are useful in diagnosing both infective and non-infective diseases. However, these indices have not been used previously to predict the differential diagnosis of common tropical febrile illnesses using a decision tree. Methods: A retrospective analysis of clinical and laboratory data of 402 patients with fever lasting for >24 h and < 3 weeks was performed. Subjects were divided into seven diagnostic groups: bacterial, viral, rickettsial, parasitic, mycobacterial, undifferentiated, and non-infective. Bivariate correlation and distribution of platelet indices among the diagnostic groups were examined. The area under the curve was obtained using these indices for each group. A classification tree was also constructed with these indices and other variables sequentially, to predict the likely cause of the fever. Results: Subjects were predominantly males (255) and young individuals (242). The most common causes of fever were viral (18.2%) and bacterial (16.8%) infections. Platelet indices varied significantly across all the groups, even after controlling for other clinical/laboratory parameters. Receiver-operating characteristic analysis showed that high platelet count had the best sensitivity and specificity for diagnosis of tuberculosis. The classification tree constructed using platelet indices alone had a higher margin of error than that using a combination of clinical symptoms, complete blood count, liver function tests, and ECG heart rate. Conclusions: Platelet indices vary significantly across tropical illnesses. Thrombocytosis has good sensitivity and specificity for diagnosis of tuberculosis. Combined with clinical symptoms and routine blood tests, these indices predicted a likely diagnosis in two-thirds of patients. Prospective validation in different localities is needed prior to the use of these indices in the diagnosis of acute febrile illnesses.
Determination of Aromatic Amines Released from Azo Dyes in Paper Packaging by Liquid Chromatography-Tandem Mass Spectrometry
Authors: Yang Fei , Bian Zhaoyang , Li Zhonghao , Fan Ziyan , Wang Ying , Liu ShanShan , Deng Huimin , Tang Gangling 
Published: June 2016

Abstract
An LC-tandem MS (LC–MS/MS) method for the determination of 21 kinds of carcinogenic aromatic amines released from azo dyes in food wrappers was used in this research. Sodium dithionite was added to a citric acid buffer medium to reduce and decompose possible azo dyes. The extract was analyzed after liquid–liquid extraction (LLE) and dispersive SPE (d-SPE). The conditions for chromatographic separation, mass spectrum, LLE, and d-SPE were optimized. Under optimal conditions, the LOD was in the range of 0.13–0.35 mg/kg and LOQ in the range of 0.38–1.05 mg/kg, with the addition of standard recoveries of most aromatic amines being ≥80% and RSDs ≤10%. The recoveries for 2,4-diaminotoluene and 2,4-diaminoanisole were significantly lower, being ≤40%. The method was successfully used to analyze 30 practical samples, and the results showed that it is user-friendly, with high sensitivity, rapid control, and low matrix interference.
Characterization of the Authenticity of Pasta di Gragnano Protected Geographical Indication Through Flavor Component Analysis by Gas Chromatography–Mass Spectrometry and Chemometric Tools
Authors: Giannetti Vanessa , Boccacci Mariani Maurizio , Mannino Paola 
Published: June 2016

Abstract
An authentication study based on headspace solid-phase microextraction/GC-MS was performed with a set of 60 samples representative of traditional “Pasta di Gragnano protected geographical indication (PGI)” and the most common Italian pasta brands. Multivariate chemometric tools were used to classify the samples based on the chemical information provided from 20 target flavor compounds, including Maillard reaction and lipid oxidation products. Pattern recognition by principal component analysis and linear discriminant analysis showed a natural grouping of samples according to the drying process adopted for their production (i.e., the traditional Cirillo method versus a high-temperature approach). Subsequently, soft independent modeling by class analogy (SIMCA) and unequal dispersed classes (UNEQ) were used to build class models at 95% confidence and 100% sensitivity levels (forced models) for predictive classification purposes. The good performance obtained from the models in terms of cross-validation efficiency (SIMCA, 57.01%; UNEQ, 86.60%; 100% for both forced models) highlighted that targeted analysis of flavor profiles could be used to assess the authenticity of Pasta di Gragnano PGI samples. Hence, the proposed method may help to protect Pasta di Gragnano PGI from label frauds by verifying whether samples comply with statements concerning drying process conditions as stated in the product specification.
Determination of Phenolic Constituents in Echinacea Raw Materials and Dietary Supplements by HPLC–UV: Collaborative Study
Authors: Brown Paula N , Mudge Elizabeth M , Paley Lori 
Published: June 2016

Abstract
A collaborative study was conducted to evaluate an HPLC method for determining phenolic compounds in Echinacea spp. raw materials, powdered extracts, and tinctures. Eleven collaborating laboratories received three practice samples representing each matrix type, phenolic reference standards, eight test samples as blind duplicates, the validated analytical method, and instructions. Test samples included two raw materials, four extracts (including one in combination with astragalus and reishi), one ethanolic tincture in combination with goldenseal, and one glycerite tincture. Each material was extracted with a 60% methanol aqueous solution, separated on a C18 column, and detected at 330 nm. Results reported by laboratories for total phenolics in Echinacea roots, aerial parts, and extracts ranged from 9.5 to 62.9 mg/g with RSDR ranging from 3.64 and 7.95% and Horwitz ratio (HorRat) values ranging from 1.06 to 2.01. Total phenolics in the ethanolic tincture ranged from 4837 to 5962 μg/mL, with an RSDR of 6.35% and a HorRat value of 1.45. The glycerite tincture showed poor interlaboratory precision with a HorRat value of 3.32, an RSDR of 21.8%, and reported total phenolic values ranging from 257 to 539 μg/mL.