bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical Laminoplasty Versus Laminectomy and Fusion
Authors: Chua Theresa , Lim Perry L. , Hershman Stuart H. , Fogel Harold A. , Tobert Daniel G. 
Published: September 2024

Study Design.
Retrospective study.

Objective.
To compare the true cost between posterior cervical laminectomy and fusion and cervical laminoplasty using time driven activity-based costing methodology.

Summary of Background Data.
Cervical laminoplasty (LP) and posterior cervical laminectomy with fusion (LF) are effective procedures for treating cervical myelopathy. A comprehensive accounting of cost differences between LP versus LF is not available. Using time-driven activity-based costing (TDABC), we sought to compare the total facility costs in patients with cervical myelopathy undergoing LP versus LF.

Materials and Methods.
We conducted a retrospective analysis of 277 LP and 229 LF performed between 2019 and 2023. Total facility costs, which included personnel and supply costs, were assessed using TDABC. Separate analyses including and excluding implant costs were performed. Multiple regression analysis was utilized to assess the independent effect of LP compared with LF on facility costs, with all costs standardized using cost units (CUs).

Results.
Patients undergoing LP had lower total supply costs [672.5 vs. 765.0 CUs (0.88x), P<0.001] and lower total personnel costs [330.0 vs. 830.0 CUs (0.40x), P<0.001], resulting in a lower total facility cost both including [1003.8 vs. 1600.0 CUs (0.63x), P<0.001] and excluding implant costs [770.0 vs. 875.0 CUs (0.88x), P<0.001] (Table 1). After controlling for demographics and comorbidities, LF was associated with increased total facility costs, including (588.5 CUs, 95% CI: 517.1–659.9 CUs, P<0.001) and excluding implant costs (104.3 CUs, 95% CI: 57.6–151.0 CUs, P<0.001).

Conclusions.
Using time-driven activity-based costing, we found that total facility costs were lower in patients treated with laminoplasty. These findings suggest that laminoplasty may offer a less costly and more efficient surgical option for treating cervical myelopathy.
TIME-COURSE RETINAL CIRCULATION CHANGES IN EYES WITH CENTRAL RETINAL ARTERY OCCLUSION USING LASER SPECKLE FLOWGRAPHY
Authors: Tanaka Shin , Soga Naoki , Hirono Kazushi , Okawa Kazuyoshi , Chin Jacob Y. H. , Kitahata Shohei , Inoue Tatsuya , Maruyama-Inoue Maiko , Kadonosono Kazuaki 
Published: September 2024

Purpose:
To evaluate retinal circulation in eyes with central retinal artery occlusion.

Methods:
The best-corrected visual acuity (BCVA), fluorescein angiography, and laser speckle flowgraphy values were measured at the first visit in 42 patients with central retinal artery occlusion (42 eyes; mean age, 66.0 ± 14.0 years). Laser speckle flowgraphy was performed at baseline, 1 week, and 1, 3, and 6 months; the difference between the mean blur rate vessel area and mean blur rate tissue area (MV-MT), reflecting the retinal vessel blood flow, was measured. Fluorescein angiography measured the arteriovenous passage time. Time-course changes in the MV-MT and BCVA, and the relationship between MV-MT and final BCVA were examined.

Results:
Mean blur rate vessel area and mean blur rate tissue area were significantly correlated with arteriovenous passage time (P < 0.001). The MV-MT increased significantly after 1, 3, and 6 months (P < 0.001). The visual acuity improved significantly until 1 month (P < 0.01). Multivariate analysis showed a significant correlation between the baseline BCVA (P < 0.001) and MV-MT at 1 month (P = 0.01) and the final BCVA. Age and MV-MT significantly negatively correlated at 1 month (P < 0.001).

Conclusion:
The retinal circulation improved significantly within 1 month; younger patients had better retinal circulation improvement. The baseline BCVA and retinal circulation within 1 month correlated with the final BCVA.
Anatomic Characteristics of Eyes With Fuchs Endothelial Corneal Dystrophy
Authors: Miller Darby D. , Wagner Isabella V. , Hasan Syed A. , Stewart Michael W. , Towne Caleb M. , Li Zhuo , Baratz Keith H. 
Published: September 2024

Purpose:
The purpose of this study was to evaluate and compare the anatomic characteristics of eyes with Fuchs endothelial corneal dystrophy (FECD) with eyes without FECD.

Methods:
This study was a retrospective chart review performed at an academic medical center. Patients with FECD were identified through a search of the electronic medical records. Eligible patients underwent Scheimpflug imaging and optical biometry and were compared with age and sex-matched control subjects who underwent similar testing in preparation for cataract surgery. Several measurements of the cornea, anterior chamber, and eyes were evaluated using multivariable linear regression models and multivariable logistic regression models.

Results:
A total of 404 eyes (202 eyes with FECD and 202 control eyes) were included in this study. Compared with controls, eyes with FECD had shallower AC depths, lower AC volumes, and narrower angles. Conversely, the spherical equivalent before cataract surgery, corneal pachymetry, and corneal volume were higher in eyes with FECD. On Scheimpflug imaging analysis, these anatomical differences were present in FECD eyes with and without corneal edema. After adjusting for sex, these differences remained statistically significant. Shorter axial length was found to be statistically significant in male eyes but not in female eyes with FECD.

Conclusions:
This study reports new ocular characteristics in FECD eyes with and without edema. Optical biometry and Scheimpflug imaging established that the anatomic findings in eyes with FECD were not simply due to the larger volume of an edematous cornea but rather unique to eyes with FECD. These findings will provide reliable, normative data for future studies examining surgical, medical, and anatomical factors in FECD.
Preoperative endoscopic ultrasound-guided biopsy for resectable pancreatic head tumors increases operative time but not complications: a single center cohort study
Authors: Wu Chien-Hui , Ho Te-Wei , Chen Ching-Hsuan , Chien Kuo-Liong , Tien Yu-Wen 
Published: September 2024

Background:
Endoscopic ultrasound-guided aspiration or biopsy allows preoperative confirmation of malignancy but is not necessary for resectable pancreatic cancer. Preoperative biopsy may induce pancreatitis, making surgery difficult and complex. Therefore, the authors performed a retrospective study to evaluate the association between preoperative endoscopic ultrasound-guided biopsy and surgical outcomes in patients with resectable pancreatic head tumors.

Materials and Methods:
A prospectively enrolled cohort from a single high-volume pancreatic center was analyzed. Between 2007 and 2019, a total of 518 patients with resectable pancreatic head tumors underwent pancreaticoduodenectomy. This analysis was performed to determine the association of preoperative endoscopic ultrasound-guided biopsy with operating time and major complications.

Results:
In 518 patients who received pancreaticoduodenectomy, 164 patients (31.6%) underwent preoperative endoscopic ultrasound-guided biopsy. Endoscopic ultrasound-guided biopsy increased surgical time (46.9 min, 95% CI: 25.1–68.8, P-value <0.05) without increasing complications (odds ratio: 0.53, 95% CI: 0.31–1.29, P-value=0.29).

Conclusion:
Preoperative endoscopic ultrasound-guided biopsy for pancreatic head tumors may increase operative time but is not associated with an increased risk of mortality and complications.
Integrating genomics and precision health knowledge into practice: A guide for nurse practitioners
Authors: Walker Trina , Ersig Anne L. , Dwyer Andrew A. , Kronk Rebecca , Snyder Cynthia T. , Whitt Karen , Willis Valerie 
Published: September 2024

ABSTRACT
Nurse practitioners (NPs) are the fastest growing group of health care providers, with an increase of 8.5% over the past year and anticipated growth of more than 40% by 2031. Improving NPs' knowledge of how genes influence health enables them to assess, diagnose, and manage patients in all states of health in a safe, efficient, and competent manner. Nurse practitioners may also care for patients who obtain direct-to-consumer (DTC) genetic tests without provider oversight and share their results; improved knowledge of genetics can provide NPs with the information and resources needed to interpret and understand DTC test results. The literature indicates that NPs have limited understanding of basic genetic concepts and guidelines for prescribing drugs affected by genomic variability. As a result, NPs report low confidence in their ability to accurately interpret and apply genetic test results, which inhibits genomics-informed precision health care. This article provides resources and clinical recommendations for using the 2021 American Association of Colleges of Nursing Essentials and the American Nurses Association Essentials of Genomic Nursing to facilitate the integration of genomics into NP curricula and practice. These resources will help future and practicing NPs integrate genomics into practice and improve precision health care.
Facial Nerve Tractography Using Diffusion MRI: A Comparison of Acquisition b-Values and Single- and Multifiber Tracking Strategies
Authors: Epprecht Lorenz , Zekelman Leo , Reinshagen Katherine L. , Xie Guoqiang , Norton Isaiah , Kikinis Ron , Makris Nikos , Piccirelli Marco , Huber Alexander , Lee Daniel J. , Zhang Fan , O'Donnell Lauren J. 
Published: September 2024

Abstract:

Hypothesis
This study investigates the impact of different diffusion magnetic imaging (dMRI) acquisition settings and mathematical fiber models on tractography performance for depicting cranial nerve (CN) VII in healthy young adults.

Background
The aim of this study is to optimize visualization of CN VII for preoperative assessment in surgeries near the nerve in the cerebellopontine angle, reducing surgery-associated complications. The study analyzes 100 CN VII in dMRI images from the Human Connectome Project, using three separate sets with different b values (b = 1,000 s/mm2, b =2,000 s/mm2, b =3,000 s/mm2) and four different tractography methods, resulting in 1,200 tractographies analyzed.

Results
The results show that multifiber and free water (FW) compartment models produce significantly more streamlines than single-fiber tractography. The addition of an FW compartment significantly increases the mean streamline fractional anisotropy (FA). Expert quality ratings showed that the highest rated tractography was the 1 tensor (1T) method without FW at b values of 1,000 s/mm2.

Conclusions
In this young and healthy cohort, best tractography results are obtained by using a 1T model without a FW compartment in b =1,000 diffusion MR images. The FW compartment increased the contrast between streamlines and cerebrospinal fluid (higher mean streamline FA). This finding may help ongoing research to improve CN VII tractography results in tumor cases where the nerve is often stretched and thinned by the tumor.
Blood Pressure During Hospital Stay for Delivery and Risk for Postpartum Readmission for Hypertension
Authors: Taylor Kaitlyn , Pochana Sai S. , Chapple Andrew G. , Dempsey Maureen , Sutton Elizabeth F. 
Published: September 2024

OBJECTIVE:
To evaluate the association of changes in peripartum blood pressure (BP) with risk for postpartum readmission for hypertension.

METHODS:
We conducted a retrospective cohort study of birthing individuals delivering from January 1, 2017, to March 1, 2020, in Louisiana. We identified patients with postpartum readmission for hypertension (readmission within 30 days of delivery) and compared BP and clinical and sociodemographic characteristics with those of patients who were not readmitted for hypertension. Patients were also grouped by their BP at both admission for delivery and 36 hours postpartum: systolic below 130 mm Hg and diastolic below 80 mm Hg, systolic 130–139 mm Hg or diastolic 80–89 mm Hg, systolic 140–149 mm Hg or diastolic 90–99 mm Hg, and systolic 150 mm Hg or higher or diastolic 100 mm Hg or higher. Logistic regression was performed to identify risk factors for postpartum readmission for hypertension.

RESULTS:
In our cohort of 17,587 individuals, 329 patients (1.9%) experienced postpartum readmission for hypertension. Increased admission BP (adjusted odds ratio [aOR] 2.26, 95% CI, 1.75–2.928), increased 36-hour postpartum BP (aOR 2.36, 95% CI, 1.58–3.53), and preeclampsia (aOR 2.47, 95% CI, 1.83–3.34) were the strongest predictors of postpartum readmission for hypertension. Black race, anemia, and increased maternal age also significantly increased the odds of postpartum readmission for hypertension (all P<.001). Elevated BP on admission for delivery showed a stepwise increased incidence of postpartum readmission for hypertension (percent readmitted among the four admission BP groups: 6.0%, 2.8%, 1.6%, and 0.7% in the 150/100 mm Hg or higher group [highest], 140–149/90–99 mm Hg group, 130–139/80–89 mm Hg group, and less than 130/80 mm Hg group [lowest], respectively).

CONCLUSION:
Even mildly elevated BP at delivery admission and persisting postpartum significantly increased risk for postpartum readmission for hypertension.
Centers for Disease Control and Prevention’s Public Health Infrastructure Grant: A Better Approach to Empowering More State and Local Decision Making and Strengthening the Public Health Workforce and Infrastructure
Authors: Carter Marion W. , Simone Patricia M. , Houry Debra E. , Reynolds Steven L. , Patterson Sara S. , Carlson Jonathan E. , Dauphin Leslie A. 
Published: September 2024

Context:
In response to the COVID-19 pandemic, Congress passed the American Rescue Plan Act of 2021 (ARPA) that included a historic investment in the public health workforce.

Program:
Charged with implementing this investment, the U.S. Centers for Disease Control and Prevention (CDC) launched the Public Health Infrastructure Grant (PHIG). PHIG builds on CDC’s experience working with state, local, and territorial public health departments and represents a new approach to strengthening the public health workforce.

Implementation:
Specifically, PHIG incorporates features that allow these public health departments to prioritize and tailor the funding to meet their communities’ needs: 1) focus on workforce as core infrastructure, 2) streamlined programmatic and administrative requirements, 3) more equitable funding approach, and 4) enhanced support from national partners and CDC.

Discussion:
The goal is to optimize the unprecedented opportunity afforded by ARPA and lead to a stronger public health workforce and infrastructure across the United States.
Paratriathlon Race Performance in Elite Ambulatory Athletes With Physical Impairments
Authors: Bevins Rachel L. 
Published: September 2024

Objective
The aim of this study was to compare overall performance and performance within the individual disciplines (e.g., swim) in elite paratriathlon between the ambulatory classes PTS2–5 in men and women.

Design
Data were acquired from the official results of 31 International paratriathlon competitions between 2018 and 2021. A total of 1094 results (men n = 774; women n = 320) were analyzed. One-way analysis of variance was used to compare overall performance time, absolute time spent in each discipline, and percentage of performance time spent in each discipline between sports classes. Pearson’s correlation between segment times and overall times were explored.

Results
Overall time was significantly quicker in PTS5 than PTS4 and PTS3 (P < 0.05), and between PTS4 and PTS3 (P < 0.05), but no differences were found between PTS3 and PTS2. PTS5 was also quicker than PTS4 and PTS3 (P < 0.05) across most of the individual discipline times. Cycling comprised the highest percentage of race time in all classes (47.1%–49.6%) and was strongly correlated to overall performance (r = 0.72–0.91).

Conclusions
Hierarchy in performance times was demonstrated between the less impaired paratriathlon classes, but not between the most impaired PTS2 and PTS3 classes. It may be appropriate for PTS2 and PTS3 to compete together.
Transition to dolutegravir-based ART in 35 low- and middle-income countries: a global survey of HIV care clinics
Authors: Zaniewski Elizabeth , Skrivankova Veronika Whitesell , Brazier Ellen , Avihingsanon Anchalee , Wagner Cardoso Sandra , Cesar Carina , Chenal Henri , Crabtree-Ramírez Brenda E. , Ditangco Rossana A. , Ebasone Peter Vanes , Eley Brian , Euvrard Jonathan George , Fatti Geoffrey , Huwa Jacqueline Madalitso , Lelo Patricia , Machado Daisy Maria , Messou Eugene Kouassi , Minga Albert Kla , Muleebwa Joseph , Mundhe Sanjay , Murenzi Gad , Muyindike Winnie R. , Nsonde Dominique Mahambou , Obatsa Sarah M. , Odhiambo Joseph , Prozesky Hans Walter , Rungmaitree Supattra , Semeere Aggrey Semwendero , Seydi Moussa , Sipambo Nosisa , Sudjaritruk Tavitiya , Technau Karl-Günter , Tiendrebeogo Thierry , Twizere Christelle , Ballif Marie 
Published: September 2024

Objective:
We studied the transition to dolutegravir-containing antiretroviral therapy (ART) at HIV treatment clinics within the International epidemiology Databases to Evaluate AIDS (IeDEA).

Design:
Site-level survey conducted in 2020–2021 among HIV clinics in low- and middle-income countries (LMICs).

Methods:
We assessed the status of dolutegravir rollout and viral load and drug resistance testing practices for persons on ART switching to dolutegravir-based regimens. We used generalized estimating equations to assess associations between clinic rollout of both first- and second-line dolutegravir-based ART regimens (dual rollout) and site-level factors.

Results:
Of 179 surveyed clinics, 175 (98%) participated; 137 (78%) from Africa, 30 (17%) from the Asia-Pacific, and 8 (5%) from Latin America. Most clinics (80%) were in low- or lower-middle-income countries, and there were a mix of primary-, secondary- and tertiary-level clinics. Ninety percent reported rollout of first-line dolutegravir, 59% of second-line, 94% of first- or second-line and 55% of dual rollout. The adjusted odds of dual rollout were higher among tertiary-level [adjusted odds ratio (aOR) 4.00; 95% confidence interval (CI) 1.39–11.47] and secondary-level clinics (aOR 3.66; 95% CI 2.19–6.11) than in primary-level clinics. Over half (59%) of clinics that introduced first- or second-line dolutegravir-based ART required recent viral load testing before switching to dolutegravir, and 15% performed genotypic resistance testing at switch.

Conclusions:
Dolutegravir-based ART was rolled out at nearly all IeDEA clinics in LMICs, yet many switched persons to dolutegravir without recent viral load testing and drug resistance testing was rarely performed. Without such testing, drug resistance among persons switching to dolutegravir may go undetected.
Liver and Kidney Tumor Masses as the Initial Presentation of B-Cell Acute Lymphoblastic Leukemia
Authors: Liu Xiaoyu , Zhong Jianping 
Published: September 2024

Abstract
We described a 13-year-old girl who presented unexplained paroxysmal sharp pain in the right upper abdomen for 3 days. CT and MRI showed multiple masses in the liver and kidneys, initially diagnosed as lymphoma. The hepatic mass biopsy confirmed B-cell lymphoblastic lymphoma. FDG PET/CT examination found that the liver and kidney masses demonstrated high metabolic activity, with concomitant increased metabolic activity in the skeleton. Bone marrow biopsy revealed extensive skeletal involvement. The final diagnosis was B-cell acute lymphoblastic leukemia. This case highlights the effectiveness of FDG PET/CT as an adjunct imaging modality for diagnosis.
Analysis of Neuroradiologic Findings in Idiopathic Intracranial Hypertension—A Population-Based Study
Authors: Steinberg Yael N. , Parnes Gregory J. , Raval Nilesh K. , Pellerano Sosa Fernando M. , Parsikia Afshin , Mbekeani Joyce N. 
Published: September 2024

Background:
Idiopathic intracranial hypertension (IIH) has been associated with several MRI features. We assessed types of MRI findings and clinical-radiologic correlations in patients with IIH from one hospital system.

Methods:
A retrospective chart review of IIH and control patients was conducted. Brain MRI/magnetic resonance venogram features were enumerated and assessed for correlation with body mass index (BMI) and lumbar puncture opening pressure (LPOP). Sensitivity, specificity, positive predictive value (PPV), and likelihood ratios (LRs) were calculated for each MRI sign. Significance was set at P < 0.05.

Results:
One hundred one patients diagnosed with IIH, and 119 control patients had complete files and were included. Patients with IIH were predominantly female (92.8% vs 59.7%; P = <0.001), younger (30.6 years vs 46.4 years; P < 0.001), and more obese (mean BMI = 35.2 vs 29.3; P < 0.001) than controls. Mean (SD) number of MRI findings was 2.21 (1.8) in IIH and 0.6 (1.2) in controls; (P < 0.001). Vertical nerve tortuosity (44.1%; P < 0.001), TVSS (37.8%; P < 0.001), sheath expansion (36.0%; P < 0.001), globe flattening (22.5%; P < 0.001), slit ventricles (18.9%; P < 0.001), optic disc protrusion (9.9%; P = 0.007), and complete empty sella (12.6%; P < 0.042) were observed more in patients with IIH than control patients. In the IIH group, mean (SD) LPOP was 33.6 (11.11) cmH2O and weakly correlated with number of MRI findings (rho = 0.182, P = 0.057). TVSS (sensitivity 37.84%; confidence interval [CI] 29.3%–47.2%, specificity 98.32%; CI 93.5%–99.6%) had the highest PPV (95.45%) and positive LR (22.51) for IIH diagnosis.

Conclusions:
These results are consistent with IIH predominance in young, obese females. In patients with IIH, the number of MRI findings exceeded controls and positively correlated with LPOP. TVSS was most predictive of IIH.
Hyphobacterium marinum sp. nov. and Hyphobacterium lacteum sp. nov., isolated from marine sediment
Authors: Zhao Shi-bo , Liu Le , Lian Feng-bai , Du Zong-Jun 
Published: September 2024

Two bacterial strains, Y60-23T and HN-65T, were isolated from marine sediment samples collected from Xiaoshi Island, Weihai, and Dongzhai Harbour, Haikou, PR China, respectively. Based on the 16S rRNA gene sequences, strain Y60-23T exhibited 96.0% similarity to its most related type strain Hyphobacterium vulgare KCTC 52487T, while strain HN-65T exhibited 97.3% similarity to its most related type strain Hyphobacterium indicum 2ED5T. The 16S rRNA gene sequence similarity between the two strains was 95.8%. Phylogenetic analysis based on 16S rRNA gene sequences showed that strains Y60-23T and HN-65T belonged to the genus Hyphobacterium. Cells of strains Y60-23T and HN-65T were rod-shaped, Gram-stain-negative, aerobic, non-motile, prosthecate and multiplied by binary fission. The major cellular fatty acids (>10.0%) of strain Y60-23T were C18 : 1
ω7c and C17 : 0, while those of strain HN-65T were iso-C17 : 1
ω9c, iso-C17 : 0 and C18 : 1
ω7c. The major respiratory quinone in both strains was ubiquinone-10 (Q-10) and the major polar lipids were monoglycosyl diglyceride, sulfoquinovosyl diacylglycerol and glucuronopyranosyl diglyceride. The genomic DNA G+C contents of strains Y60-23T and HN-65T were 63.9 and 60.7 mol%, respectively. The average nucleotide identity value between the two strains was 72.1% and the DNA–DNA hybridization value was 18.4%, clearly distinguishing them from each other. According to the results of the phenotypic, chemotaxonomic, phylogenetic and genomic analyses, the two strains represented two novel species within the genus Hyphobacterium, for which the names Hyphobacterium marinum sp. nov. and Hyphobacterium lacteum sp. nov. were proposed with the type strains Y60-23T (=MCCC 1H01433T=KCTC 8172T) and HN-65T (=MCCC 1H01434T=KCTC 8169T), respectively.