bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Risk Prediction of Atrial Fibrillation
Authors: Lubitz Steven A. , Yin Xiaoyan , Lin Henry J. , Kolek Matthew , Smith J. Gustav , Trompet Stella , Rienstra Michiel , Rost Natalia S. , Teixeira Pedro L. , Almgren Peter , Anderson Christopher D. , Chen Lin Y. , Engström Gunnar , Ford Ian , Furie Karen L. , Guo Xiuqing , Larson Martin G. , Lunetta Kathryn L. , Macfarlane Peter W. , Psaty Bruce M. , Soliman Elsayed Z. , Sotoodehnia Nona , Stott David J. , Taylor Kent D. , Weng Lu-Chen , Yao Jie , Geelhoed Bastiaan , Verweij Niek , Siland Joylene E. , Kathiresan Sekar , Roselli Carolina , Roden Dan M. , van der Harst Pim , Darbar Dawood , Jukema J. Wouter , Melander Olle , Rosand Jonathan , Rotter Jerome I. , Heckbert Susan R. , Ellinor Patrick T. , Alonso Alvaro , Benjamin Emelia J. 
Published: October 2016

Background:
Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke.

Methods:

To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in 5 prospective studies comprising 18 919 individuals of European ancestry. We examined associations between AF genetic risk scores and ischemic stroke in a separate study of 509 ischemic stroke cases (202 cardioembolic [40%]) and 3028 referents. Scores were based on 11 to 719 common variants (≥5%) associated with AF at
P
values ranging from <1×10
−3
to <1×10
−8
in a prior independent genetic association study.

Results:

Incident AF occurred in 1032 individuals (5.5%). AF genetic risk scores were associated with new-onset AF after adjustment for clinical risk factors. The pooled hazard ratio for incident AF for the highest versus lowest quartile of genetic risk scores ranged from 1.28 (719 variants; 95% confidence interval, 1.13–1.46;
P
=1.5×10
−4
) to 1.67 (25 variants; 95% confidence interval, 1.47–1.90;
P
=9.3×10
−15
). Discrimination of combined clinical and genetic risk scores varied across studies and scores (maximum C statistic, 0.629–0.811; maximum ΔC statistic from clinical score alone, 0.009–0.017). AF genetic risk was associated with stroke in age- and sex-adjusted models. For example, individuals in the highest versus lowest quartile of a 127-variant score had a 2.49-fold increased odds of cardioembolic stroke (95% confidence interval, 1.39–4.58;
P
=2.7×10
−3
). The effect persisted after the exclusion of individuals (n=70) with known AF (odds ratio, 2.25; 95% confidence interval, 1.20–4.40;
P
=0.01).

Conclusions:
Comprehensive AF genetic risk scores were associated with incident AF beyond associations for clinical AF risk factors but offered small improvements in discrimination. AF genetic risk was also associated with cardioembolic stroke in age- and sex-adjusted analyses. Efforts are warranted to determine whether AF genetic risk may improve identification of subclinical AF or help distinguish between stroke mechanisms.
The City of Terrorism or a City for Breakfast
Authors: Marilungo Francesco 
Published: October 2016

This article focuses on the image of the city of Diyarbakir as it is presented in the TV series Sultan (28 May 2012 to 29 October 2012). It considers the sense of place as portrayed on screen and assesses the sociopolitical implications of the spatial representations of the TV series. It questions the concept of a real image of the city, as discussed by commentators and viewers of Sultan, to show how ‘public chatter’ (Öncü 2011) about the show reinforces arbitrary depictions of Diyarbakir. Finally, this article considers how efforts to commodify the city for the tourist market affect Sultan’s depiction of urban space. All traces of political conflict, violence and traumatic memory are erased, while a tacit ‘ethnic hierarchy’ (Scalbert-Yücel 2015) that structures the Turkish mosaic of cultures informs the series.
A Taxonomic Revision of the genus Dialium (Leguminosae: Dialiinae) in the Netotropics
Authors: JUNIOR MARCUS JOSÉ DE AZEVEDO FALCÃO , PINTO RAFAEL BARBOSA , MANSANO VIDAL DE FREITAS 
Published: November 2016

Dialium (Leguminosae, Dialiinae) is pantropical and comprises about 40 species. Presently, only one species occurs in the Neotropics, Dialium guianense, which is found from eastern Mexico to northeastern Minas Gerais, Brazil. The objective of this study was to carry out a thorough taxonomic revision of Dialium in the Neotropics, to determine if species diversity of the genus in this region is underestimated. The study analyzed 765 collections, from 18 herbaria throughout the world, which revealed three groups of specimens that clearly differ from each other and from D. guianense. Morphology and biogeography support their recognition as new species. Dialium hexaestaminatum occurs in northern Colombia and western Venezuela, and is characterized by generally having six stamens, while the other neotropical species have only two. Dialium congestum occurs in Ecuador and southern Colombia and is mainly characterized by the presence of congested inflorescences, unlike the lax inflorescences found in the other neotropical species. Dialium rondoniense occurs in the state of Rondônia and the most southern part of the state of Amazonas, Brazil. It is characterized by the dense coverage of trichomes on the abaxial surface of the leaflets, as well as the petiolules, petioles, leaf rachis and branches, while the other neotropical species are generally glabrous or covered with sparse trichomes that are imperceptible to the bare eye. The results show that the diversity of Dialium in the Neotropics was underestimated and that the genus has four species in the region. An identification key, illustrations and descriptions of the species are provided.
Running Memory for Clinical Handoffs: A Look at Active and Passive Processing
Authors: Anderson-Montoya Brittany L. , Scerbo Mark W. , Ramirez Dana E. , Hubbard Thomas W. 
Published: October 2016

Objective: The goal of the present study was to examine the effects of domain-relevant expertise on running memory and the ability to process handoffs of information. In addition, the role of active or passive processing was examined. Background: Currently, there is little research that addresses how individuals with different levels of expertise process information in running memory when the information is needed to perform a real-world task. Method: Three groups of participants differing in their level of clinical expertise (novice, intermediate, and expert) performed an abstract running memory span task and two tasks resembling real-world activities, a clinical handoff task and an air traffic control (ATC) handoff task. For all tasks, list length and the amount of information to be recalled were manipulated. Results: Regarding processing strategy, all participants used passive processing for the running memory span and ATC tasks. The novices also used passive processing for the clinical task. The experts, however, appeared to use more active processing, and the intermediates fell in between. Conclusion: Overall, the results indicated that individuals with clinical expertise and a developed mental model rely more on active processing of incoming information for the clinical task while individuals with little or no knowledge rely on passive processing. Application: The results have implications about how training should be developed to aid less experienced personnel identify what information should be included in a handoff and what should not.
Accounting for refrigeration heat exchange in energy performance simulations of large food retail buildings
Authors: Parker James , Glew David , Fletcher Martin , Thomas Felix , Gorse Christopher 
Published: October 2016

Heat exchange between chilled food storage and conditioned spaces in large food retail stores is not currently required as part of design stage regulatory compliance energy performance models. Existing work has identified that this exchange has a significant impact on store energy demand and subsequently leads to unrealistic assessment of building performance. Research presented in this article uses whole building dynamic thermal simulation models that are calibrated against real store performance data, quantifying the impact of the refrigeration driven heat exchange. Proxy refrigerated units are used to simulate the impact of these units for the sales floor areas. A methodology is presented that allows these models to be simplified with the aim of calculating a realistic process heat exchange for refrigeration and including this in thermal simulation models; a protocol for the measurement of chilled sales areas and their inclusion in the building models is also proposed. It is intended that this modelling approach and the calculated process heat exchange inputs can be used to improve the dynamic thermal simulation of large food retail stores, reduce gaps between predicted and actual performance and provide more representative inputs for design stage and regulatory compliance energy calculations. Practical application: The modelling methodology and research findings presented in the article are of practical use for building energy modelling engineers using dynamic simulation models to design and/or evaluate the energy performance of large food retail stores. The methodology can be used in the design of new facilities or the evaluation of large scale retrofit projects. It is also of practical interest to energy and facility managers within large food retail organisations as it will aid their understanding of applied energy performance models.
Osteochondral Allograft Donor-Host Matching by the Femoral Condyle Radius of Curvature
Authors: Bernstein Derek T. , O’Neill Craig A. , Kim Ryan S. , Jones Hugh L. , Noble Philip C. , Harris Joshua D. , McCulloch Patrick C. 
Published: October 2016

Background: Conventional osteochondral allograft (OCA) matching, requiring orthotopic, size-matched condyles, and narrow surgical time windows often prohibit timely transplantation. Hypothesis: The femoral condyle radius of curvature (RoC) is an appropriate, isolated criterion for donor-host matching in fresh OCAs, potentially enhancing matching efficiency when compared with conventional matching techniques. Study Design: Descriptive laboratory study. Methods: In part 1 of this study, 3-dimensional digital reconstructions of 14 randomly selected, cadaveric distal femoral hemicondyles were performed. Each condyle was divided into anterior, middle, and posterior zones. A virtual best-fit grid was applied to each, and each zone’s sagittal- and coronal-plane RoCs were determined. Seven nonorthotopic OCA transplantations were performed based on RoC matching with 1-mm tolerance, and the preoperative and postoperative surface geometry were quantified to assess the accuracy of articular surface restoration. Of note, each donor-host pair did not match by the conventional method. In part 2 of this study, 12 cadaveric distal femora were categorized by size and digitized in the aforementioned manner. Simulated circular defects measuring 20, 25, and 30 mm in diameter were introduced into each zone. OCA matches were determined based on donor and host RoCs, and the total number of potential matches (of 71 total comparisons) was recorded as a percentage for each simulated defect. Finally, the results of RoC matching were compared with the conventional method for simulated defects in all zones of both the medial and lateral femoral condyles. Results: Part 1: The mean surface deviation after OCA transplantation was −0.09 mm, with a mean maximum protrusion at any point of 0.59 mm. Part 2: Using the RoC, 20-mm defects had a 100% chance of being matched. Defects of 25 and 30 mm had a 91% and 64% chance of being matched, respectively. Compared with the conventional method, the RoC method yielded a 3.2-fold greater match rate for lesions of the medial and lateral femoral condyles ( P = .02). Conclusion: This investigation shows that femoral condyle RoCs in the sagittal and coronal planes may be useful, alternative matching criteria, expanding on current standards. Clinical Relevance: These matching criteria may increase the number of available matches, reduce wait times for patients, and reduce the number of wasted grafts.
Superior Labrum Anterior-Posterior Tears in the National Football League
Authors: Chambers Caitlin C. , Lynch T. Sean , Gibbs Daniel B. , Ghodasra Jason H. , Sahota Shawn , Franke Kristina , Mack Christina D. , Nuber Gordon W. 
Published: October 2016

Background: Shoulder disorders are common in football players, with up to 50% of National Football League (NFL) recruits reporting a history of shoulder injuries. Superior labrum anterior-posterior (SLAP) tears are an entity with well-described detrimental effects on return to play in overhead-throwing athletes but with minimal data in contact athletes. Purpose: To identify the incidence, predisposing factors, and effect of SLAP tears in NFL athletes and prospects as well as the treatment patterns of NFL team physicians. Study Design: Descriptive epidemiology study. Methods: This study was a comprehensive analysis of SLAP tears in elite football players using a dual approach: (1) SLAP injuries recorded in the NFL Injury Surveillance System from 2000 to 2014 were evaluated by player position, type of play, days/games lost, and surgical intervention; (2) NFL Scouting Combine athletes from 2003 to 2011 with prior SLAP repair were evaluated for draft success, and drafted athletes were compared with matched controls for career length and performance scores. Results: SLAP tears represented a small portion (3.1%) of shoulder injuries in NFL athletes from 2000 to 2014, occurring most commonly in offensive linemen (28%). Surgically treated SLAP tears (42%) resulted in more days missed than did nonoperatively managed tears (140.2 vs 21.5 days; P < .001) and more games missed (8.4 vs 2.6 games; P = .003). SLAP repairs were also rare in NFL Combine athletes (n = 25 of 2965 athletes), with most having been performed in offensive linemen (32%). As compared with control NFL Combine athletes without SLAP tears, those drafted into the NFL with prior SLAP repair played significantly fewer games (33.7 vs 48.3; P = .049) and had fewer game starts (19.6 vs 35.4; P = .036). Conclusion: In this comprehensive analysis of SLAP tears in elite football players, it is clear that these injuries have the potential to cause significant detriment to an athlete’s career.
Is it better to invest in hard or soft skills?
Authors: Balcar Jiří 
Published: October 2016

AbstractIncreasing awareness of the productive potential of soft skills has sparked a discussion of their systematic and purposeful development. However, education systems pay only limited attention to this topic in most countries and remain focused on the development of hard skills. Is this approach rational or inadequate? This article provides new evidence on different aspects of the wage returns to soft skills (as an approximation of their productivity), and thereby contributes significantly to the discussion of the role of educational institutions in their development. It provides evidence that soft skills are as productive as hard skills. Moreover, it suggests that the productivity of hard skills stems from their combination with soft skills. These conclusions do not correspond to the fact that the value of education is intermediated mainly by hard skills, resulting in unequal development of soft and hard skills in schools. While concluding that education systems should pay more attention to soft skills development, the analysis recognises that this attention should be differentiated according to employers’ needs, owing to substantial differences in the value of soft skills across economic sectors. It is also noteworthy that while significant gender differences in returns to hard skills were identified, wage returns to soft skills appear gender neutral.
The Effects of Mindfulness Meditation on Hope and Stress
Authors: Munoz Ricky T. , Hoppes Steve , Hellman Chan M. , Brunk Kara L. , Bragg Jedidiah E. , Cummins Carissa 
Published: October 2016

Purpose: To evaluate mindfulness meditation as an antecedent of reductions in stress and increases in hope. Method: A quasi-experimental design ( N = 46; meditation group, n = 23; comparison group, n = 23) using a community sample was used to evaluate the impact of mindfulness meditation on stress and hope. A path analysis was also used to model a directional relationship between meditation participation and increases in hope mediated by reductions in stress. Results: The data indicated that the meditation group exhibited significantly higher hope and lower stress than the comparison group. The path analysis indicated that reductions in stress fully mediated the relationship between mindfulness meditation and increases in hope. Discussion: The data support that meditation can increase hope via stress reduction. The results suggest a need for further research into mindfulness meditation and hope, especially since increasing hope is a fundamental aim of strengths-based practice.
Development and implementation of a hospital-based trauma response system in an urban hospital in San Salvador, El Salvador
Authors: Cioè-Peña EC , Granados JC , Wrightsmith LL , Henriquez-Vigil AL , Moresky RT 
Published: October 2016

Background In El Salvador, over 32% of all deaths are due to trauma. However, El Salvador lacks any established standardized trauma response system to treat the most critical of Salvadoran patients. In an effort to improve trauma response in El Salvador, we assessed the impact of a trauma-specific skills training, which could improve trauma care in a setting where no formal trauma training exists. Methods We used a pre- and post-interventional design study to measure the critical actions performed during a trauma event, as well as the case-fatality rate, emergency ward-to-operating room time, and utilization of ultrasound. The intervention was a primary trauma care course taught to all study participants. Results Eighteen providers were observed over a six-month period and 194 patient encounters (48 pre- and 146 post-intervention) were recorded. There was no significant difference in observed critical actions during major trauma between the pre-intervention and post-intervention periods. There was a significant improvement in ultrasound usage post-intervention (9.5% to 21.4%; p = 0.04). Conclusion The lack of behavior change observed following a two-day trauma training underscores the gap between physician knowledge and applied behavior change. This is a limited single center study, but further examination is necessary to determine the role of two-day training courses in the larger context of behavior change within a health system that has no formal post-graduate training in or defined algorithmic trauma care.
Global stroke statistics
Authors: Thrift Amanda G , Thayabaranathan Tharshanah , Howard George , Howard Virginia J , Rothwell Peter M , Feigin Valery L , Norrving Bo , Donnan Geoffrey A , Cadilhac Dominique A 
Published: October 2016

Background Up to date data on incidence, mortality, and case-fatality for stroke are important for setting the agenda for prevention and healthcare. Aims and/or hypothesis We aim to update the most current incidence and mortality data on stroke available by country, and to expand the scope to case-fatality and explore how registry data might be complementary. Methods Data were compiled using two approaches: (1) an updated literature review building from our previous review and (2) direct acquisition and analysis of stroke events in the World Health Organization (WHO) mortality database for each country providing these data. To assess new and/or updated data on incidence, we searched multiple databases to identify new original papers and review articles that met ideal criteria for stroke incidence studies and were published between 15 May 2013 and 31 May 2016. For data on case-fatality, we searched between 1980 and 31 May 2016. We further screened reference lists and citation history of papers to identify other studies not obtained from these sources. Mortality codes for ICD-8, ICD-9, and ICD-10 were extracted. Using population denominators provided for each country, we calculated both the crude mortality from stroke and mortality adjusted to the WHO world population. We used only the most recent year reported to the WHO for which both population and mortality data were available. Results Fifty-one countries had data on stroke incidence, some with data over many time periods, and some with data in more than one region. Since our last review, there were new incidence studies from 12 countries, with four meeting pre-determined quality criteria. In these four studies, the incidence of stroke, adjusted to the WHO World standard population, ranged from 76 per 100,000 population per year in Australia (2009–10) up to 119 per 100,000 population per year in New Zealand (2011–12), with the latter being in those aged at least 15 years. Only in Martinique (2011–12) was the incidence of stroke greater in women than men. In countries either lacking or with old data on stroke incidence, eight had national clinical registries of hospital based data. Of the 128 countries reporting mortality data to the WHO, crude mortality was greatest in Kazhakstan (in 2003), Bulgaria, and Greece. Crude mortality and crude incidence of stroke were both positively correlated with the proportion of the population aged ≥ 65 years, but not with time. Data on case-fatality were available in 42 studies in 22 countries, with large variations between regions. Conclusions In this updated review, we describe the current data on stroke incidence, case-fatality and mortality in different countries, and highlight the growing trend for national clinical registries to provide estimates in lieu of community-based incidence studies.
Breaking up sitting time after stroke (BUST-Stroke)
Authors: Janssen Heidi , Dunstan David W , Bernhardt Julie , Walker Frederick R , Patterson Amanda , Callister Robin , Dunn Ashlee , Spratt Neil J , English Coralie 
Published: October 2016

Rationale Prolonged sitting is associated with an increased risk of cardiovascular and all-cause mortality and morbidity. The metabolic and cardiovascular effects of breaking up sitting time in people with stroke are unknown. Aims and hypotheses To determine the (i) metabolic and cardiovascular effects and (ii) safety and feasibility of an experimental protocol to break up uninterrupted sitting in people with stroke. We hypothesize that activity breaks will attenuate the effects of uninterrupted sitting on glucose and insulin metabolism, blood pressure, lipid profiles, and plasma fibrinogen and that it will be both safe and feasible. Sample size estimate Based on previous estimates of population variability (SD 1% glucose and 30% insulin), 19 paired observations (i.e. participants) will achieve a power of 0.9 to detect a difference of 0.8% in glucose and 24% in insulin area under the curve (two-tailed testing, α = 0.05). Methods and design People with stroke will complete three experimental conditions one week apart in randomized order: (a) uninterrupted sitting, (b) prolonged sitting with intermittent walking, and (c) prolonged sitting with intermittent standing exercises. Serial blood samples will be collected and blood pressure measured at 30 min intervals for 8 h. Study outcomes Primary outcome will be postprandial glucose and insulin responses. Secondary outcomes will include fibrinogen concentrations, blood pressure, and adverse events and protocol feasibility. Discussion This is the first important step in determining the cardiovascular effects of breaking up sitting time after stroke. Findings will guide future studies testing behavioral strategies to reduce sitting time for the purpose of lowering recurrent stroke risk.