bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B‐cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi
Authors: Luminari Stefano , Viel Elda , Ferreri Andrés José Maria , Zaja Francesco , Chimienti Emanuela , Musuraca Gerardo , Tucci Alessandra , Balzarotti Monica , Tani Monica , Salvi Francesca , Pesce Emanuela A. , Ferrari Angela , Liberati Anna M. , Spadea Antonio , Marino Dario , Bruno‐Ventre Maria , Volpetti Stefano , Bottelli Chiara , Ravaioli Elena , Merli Francesco , Spina Michele 
Published: May 2017

AbstractThe purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of “R‐COMP” combination in patients with diffuse large B‐cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35%), followed by atrial fibrillation (15%), left ventricular hypertrophy (13%), and baseline LVEF <50% (12%). Based on the intent to treat analysis, overall response rate was 72%, including 28 patients in complete remission (complete remission rate, 56%), and 8 in partial remission (16%). At the end of treatment, grades 3 to 4 cardiac events were observed in 6 patients. No significant modifications from baseline values of LVEF were observed during treatment and follow‐up. Nonpegylated liposomal doxorubicin instead of doxorubicin in the R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen is a feasible option for patients with diffuse large B‐cell lymphoma presenting with concomitant cardiac disorders.
Kripalu Yoga for Military Veterans With PTSD: A Randomized Trial
Authors: Reinhardt Kristen M. , Noggle Taylor Jessica J. , Johnston Jennifer , Zameer Abida , Cheema Seetal , Khalsa Sat Bir S. 
Published: May 2017

ObjectivesThis randomized controlled trial of yoga for military veterans and active duty personnel with posttraumatic stress disorder (PTSD) evaluated the efficacy of a 10‐week yoga intervention on PTSD.MethodFifty‐one participants were randomized into yoga or no‐treatment assessment‐only control groups. Primary outcome measures included questionnaires and the Clinician Administered PTSD Scale.ResultsBoth yoga (n = 9) and control (n = 6) participants showed significant decreases in reexperiencing symptoms, with no significant between‐group differences. Secondary within‐group analyses of a self‐selected wait‐list yoga group (n = 7) showed significant reductions in PTSD symptoms after yoga participation, in contrast to their control group participation. Consistent with current literature regarding high rates of PTSD treatment dropout for veterans, this study faced challenges retaining participants across conditions.ConclusionThese results are consistent with recent literature indicating that yoga may have potential as a PTSD therapy in a veteran or military population. However, additional larger sample size trials are necessary to confirm this conclusion.
Cost effective recovery of lithium from lithium ion battery by reverse osmosis and precipitation: a perspective
Authors: Swain Basudev 
Published: May 2017

AbstractProduction of lithium from primary resources is lagging behind demand (12% versus 16% in 2016), cost of lithium is increasing (between 40 and 60% in 2016), battery energy density rapidly increasing versus declining cost, and estimated lithium ion battery (LIB) markets size ($77.42 billion by 2024) driven by projected demands for plug‐in electric vehicles (PEVs) clearly justifies recycling. PEV technology and projected demand raise several challenges, including lithium demand/scarcity and future technology to recover lithium from LIB waste. To address the circular economy, steady supply chain security, self‐reliance, environment safety, environment directive, energy security, resources conservation, futuristic carbon footprint, WEEE directives and waste crime, recycling of LIB is an absolute essential. During the last decade, LIB recycling research and industrial recycling of LIB have attracted the interest of researchers, industrialists, and environmentalists. All have reported progress in the recovery of valuable metals like Co, but have rarely focused on lithium recovery. Hence, this paper addresses logical hypothesis and application of available technology in a fashion where lithium recycling from LIB can be addressed. © 2017 Society of Chemical Industry
On an anti‐Ramsey threshold for sparse graphs with one triangle
Authors: Kohayakawa Y. , Konstadinidis P. B. , Mota G. O. 
Published: May 2017

AbstractFor graphs G and H, let denote the property that for every proper edge‐coloring of G (with an arbitrary number of colors) there is a rainbow copy of H in G, that is, a copy of H with no two edges of the same color. The authors (2014) proved that, for every graph H, the threshold function of this property for the binomial random graph is asymptotically at most , where denotes the so‐called maximum 2‐density of H. Nenadov et al. (2014) proved that if H is a cycle with at least seven vertices or a complete graph with at least 19 vertices, then . We show that there exists a fairly rich, infinite family of graphs F containing a triangle such that if for suitable constants and , where , then almost surely. In particular, for any such graph F.
Synthesis and Biological Evaluation of 2‐substituted‐6‐(morpholinyl/piperidinyl)pyridazin‐3(2H)‐ones as Potent and Safer Anti‐inflammatory and Analgesic Agents
Authors: Singh Jyoti , Sharma Deepika , Bansal Ranju 
Published: May 2017

A series of 2‐substituted‐6‐(morpholinyl/piperidinyl)pyridazin‐3(2H)‐ones was synthesized and the structures were established using various spectroscopic techniques. The target compounds were screened for anti‐inflammatory and analgesic activities at 20 and 40 mg/kg. The safety of the synthesized derivatives was evaluated by assessing anti‐platelet activity and ulcer index. The obtained pharmacological data revealed that 6‐morpholinyl derivatives 4a–12a were found to be somewhat more potent than 6‐piperidinyl derivatives 4b–6b. The 6‐morpholinyl substituted pyridazinone 12a exhibited maximum anti‐inflammatory and analgesic activities. Homoveratrylamine substituted compounds 6a and 6b emerged as promising leads in both the series with good anti‐inflammatory and analgesic activities without any ulcerogenicity. Anti‐platelet activity results of the compounds of both the series showed significantly low bleeding time in comparison with standard drug aspirin indicating the cardiovascular safety of new pyridazinones.
Bringing modelled and observed surface winds together
Authors: van den Brink Henk W. , Bosveld Fred C. 
Published: May 2017

ABSTRACTThe 10 m‐wind over flat terrain in models is often lower than observations indicate. Here we show that this negative bias is mainly caused by the larger roughness lengths that models use than the World Meteorological Organisation (WMO)‐advised roughness length of short grass (0.03 m). The concept of potential wind, which transforms the original wind to the theoretical wind under the assumption of a local roughness of 0.03 m, is well suited to distinguish this effect from other causes. It shows that the yearly averaged bias in Hirlam Aladin Research on Meso‐scale Operational NWP (numerical weather prediction) in Euromed (HARMONIE) is largely due to roughness effects. The year‐to‐year variations are caused by misrepresentations of the weather situations by HARMONIE. This can be concluded from the analysis of the geostrophic wind, which is insensitive for roughness effects.Although the yearly averaged potential wind speed is well represented, HARMONIE reveals a strong seasonal cycle in the bias, being too low in summer, and slightly too high in winter. This is mainly caused by a too strong seasonal cycle in the representation of the leaf area index.The HARMONIE data set points out to underestimate the average wind over The Netherlands up to 10% in the period before 1995. Even after correction for roughness effects, an underestimation of 6% remains. It is likely that the disappearance of the bias after 1995 is caused by the gradually improved quality of the ERA‐Interim data set with time.
Onset of the Bay of Bengal summer monsoon and the seasonal timing of ENSO's decay phase
Authors: Sun Shuyue , Ren Rongcai , Wu Guoxiong 
Published: May 2017

ABSTRACTBased on multiple sources of atmospheric and oceanic data, this study demonstrates a close relationship between the onset of the Bay of Bengal (BOB) summer monsoon (BOBSM) and the seasonal timing of El Niño–Southern Oscillation (ENSO)'s decay phase. Through distinguishing ‘later‐decay’ and ‘normal‐decay’ ENSO events, it is found that a later/earlier onset of the BOBSM following El Niño/La Niña is mainly caused by later‐decay ENSO events, while no significant changes in BOBSM onset can be identified between normal‐decay El Niño and normal‐decay La Niña events. Diagnosis of the related dynamic and thermodynamic processes further confirms that, for later‐decay ENSO events that remain active until mid‐April, persistent ENSO‐induced ‘atmospheric‐bridge’ processes can yield a stronger vertical coupling of circulation between the upper and lower troposphere, and thus an anomalously earlier (later) BOBSM onset following a later‐decay La Niña (El Niño). In the lower troposphere, the persisting zonal sea surface temperature (SST) gradient between the Indian Ocean and the western Pacific following later‐decay ENSO events can significantly modulate the lower tropospheric barotropic instability over the northern BOB, which in turn overwhelms the local SST conditions to dominate the development of monsoon convections. In the upper troposphere, later‐decay ENSO alters the position of the South Asian high and the upper atmospheric divergence‐pumping through the anomalous Walker circulation. In contrast, due to the earlier damping of normal‐decay ENSO, the BOBSM onset processes are barely modulated.
Feasibility of near infrared transmittance spectroscopy to predict fatty acid composition of commercial processed meat
Authors: De Marchi Massimo , Manuelian Carmen L , Ton Sofia , Cassandro Martino , Penasa Mauro 
Published: May 2017

AbstractBACKGROUNDThe new European Regulation 1169/2011 concerning nutrition declaration of food products compels the addition of saturated fatty acids, whereas the declaration of monounsaturated and polyunsaturated fatty acids remains voluntary. Therefore, the industry is interested in a more rapid, easy and less cost‐effective analysis method for accomplishing this labelling regulation. The present study aimed to evaluate the ability of near infrared transmittance spectroscopy (wavelengths between 850 and 1050 nm) to predict the fatty acid (FA) composition of commercial processed meat samples (n = 310).RESULTSGood predictions were achieved for the absolute content of saturated, unsaturated, monounsaturated and polyunsaturated FA, as well as ω‐6 groups, and also for a few individual FA (C16:0, C18:0, C18:1n9, C18:2n6 and 18:1n7), with the coefficient of determination in cross‐validation being > 0.90 and the residual prediction deviation being > 3.15. Unsatisfactory models were obtained for the relative content of FA.CONCLUSIONNear infrared transmittance spectroscopy can be considered as a reliable method for predicting the main groups of FA in processed meat products, whereas predictions of individual FA are less reliable. © 2017 Society of Chemical Industry
Dietary supplementation of l‐arginine and chromium picolinate in sows during gestation affects the muscle fibre characteristics but not the performance of their progeny
Authors: Shi Zhan , Song Wentao , Sun Yuecheng , Wang Liansheng , Shi Baoming , Shan Anshan , Bi Zhongpeng 
Published: May 2017

AbstractBACKGROUNDThe present study investigated the effects of dietary supplementation of l‐arginine and chromium picolinate (CrP) in sows during gestation on muscle fibre characteristics, performance and carcass characteristics of their progeny. Sixty healthy sows were randomly divided into four groups as a 2 × 2 factorial experiment design: one group received the control diet, another received the control diet + 10 g kg−1 l‐arginine, the third group received the control diet + 400 ppb CrP, and the fourth group received the control diet + 10 g kg−1 l‐arginine and 400 ppb CrP.RESULTSThe results showed that sows fed the diet supplemented with CrP produced progeny with higher muscle fibre numbers at birth, weaning and slaughter compared to sows fed the control diet. For mean fibre areas, the same result was found at weaning. For progeny of sows fed diets supplemented with l‐arginine, only higher muscle fibre numbers at slaughter was observed. Almost no differences were observed regarding average daily gains, average daily feed intake, gain‐to‐feed ratios, carcass and meat traits.CONCLUSIONThe results of the present study indicate that dietary supplementation of l‐arginine and particularly CrP in sows during gestation alters muscle fibre numbers in their offspring, although not their performance or carcass characteristics. © 2017 Society of Chemical Industry
Augmented low index waveguide for confining light in low index media
Authors: Alam Muhammad Z. , Sun Xiao , Mojahedi Mo , Aitchison J. Stewart 
Published: May 2017

AbstractGuiding light in the low index region of a high refractive index contrast waveguide can be beneficial for many applications including sensing, nonlinear optics and electro‐optics. Existing methods to achieve this goal suffer from fabrication complexity, large loss, or poor optical confinement. We propose a simple structure to achieve a significant enhancement of light confinement in the low index medium. We explain the guiding principle of this structure using geometrical optics, and suggest a number of applications where this guiding structure can provide significant performance benefits. The combination of simplicity, ease of fabrication, and good confinement makes this waveguide an attractive choice for a wide range of applications. To illustrate this, we consider the integration of a nonlinear polymer with a silicon photonic waveguide, and show that significantly better performance with an easier fabrication process can be achieved using this new scheme.
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Investigating the effect of carbon source on rabies virus glycoprotein production inPichia pastorisby a transcriptomic approach
Authors: Ben Azoun Safa , Kallel Héla 
Published: May 2017

AbstractSeveral factors affect protein expression inPichia pastoris, one among them is the carbon source. In this work, we studied the effect of this factor on the expression level of rabies virus glycoprotein (RABV‐G) in two recombinant clones harboring seven copies of the gene of interest. The expression was driven either by the constitutive glyceraldehyde‐3‐phosphate dehydrogenase (GAP) promoter or the inducible alcohol oxidase1(AOX1) promoter. Clones were compared in terms of cell physiology and carbon source metabolism. The transcription levels of 16 key genes involved in the central metabolic pathway, the methanol catabolism, and the oxidative stress were investigated in both clones. Cell size, as a parameter reflecting cell physiological changes, was also monitored. Our results showed that when glucose was used as the sole carbon source, large cells were obtained. Transcript levels of the genes of the central metabolic pathway were also upregulated, whereas antioxidative gene transcript levels were low. By contrast, the use of methanol as a carbon source generated small cells and a shift in carbon metabolism toward the dissimilatory pathway by the upregulation of formaldehyde dehydrogenase gene and the downregulation of those of the central metabolic. These observations are in favor of the use of glucose to enhance the expression ofRABV‐G inP. pastoris.
Statistical Model Based HPLC Analytical Method Adjustment Strategy to Adapt to Different Sets of Analytes in Complicated Samples
Authors: Yan Binjun , Bai Xue , Sheng Yunjie , Li Fanzhu 
Published: May 2017

AbstractIntroductionOn account of the complicated compositions of the products like traditional Chinese medicines (TCMs) and functional foods, it is a common practice to determine different sets of analytes in the same product for different purposes.ObjectiveTo efficiently develop the corresponding HPLC methods, a statistical model based analytical method adjustment (SMB‐AMA) strategy was proposed.MethodsIn this strategy, the HPLC data acquired with design of experiments methodology were efficiently utilised to build the retention models for all the analytes and interferences shown in the chromatograms with multivariate statistical modelling methods. According to the set of analytes under research, Monte‐Carlo simulations were conducted based on these retention models to estimate the probability of achieving adequate separations between all the analytes and their interferences. Then the analytical parameters were mathematically optimised to the point giving a high value of this probability to compose a robust HPLC method. Radix Angelica Sinensis (RAS) and its TCM formula with Folium Epimedii (FE) were taken as the complicated samples for case studies.ResultsThe retention models for the compounds in RAS and FE were built independently with correlation coefficients all above 0.9799. The analytical parameters were tactfully adjusted to adapt to six cases of different sets of analytes and different sample matrices. In the validation experiments using the adjusted analytical parameters, satisfactory separations were acquired.ConclusionThe results demonstrated that the SMB‐AMA strategy was able to develop HPLC methods rationally and rapidly in the adaption of different sets of analytes. Copyright © 2017 John Wiley & Sons, Ltd.
The contribution of direct patient reported ADRs to drug safety signals in the Netherlands from 2010 to 2015
Authors: van Hunsel Florence , de Waal Susan , Härmark Linda 
Published: May 2017

AbstractPurposeThe purpose of this study was to investigate the contribution of patient reports to signals sent by the Netherlands Pharmacovigilance Centre Lareb to the Dutch Medicines Evaluation Board and to determine if there are certain types of signals where patient report add a distinct contribution.MethodAll signals from 2010 until 2015 were included. First, we investigated how many patient reports were present in the signals and the characteristics of these reports compared to the health care professional and marketing authorization holders' reports.In addition to source, the analysis included ATC code of the drug, MedDRA® system organ class and preferred term for the adverse drug reaction (ADR), seriousness of the ADR, and 7 other factors like reports on over‐the‐counter medication, and how often an ADR listed in the important medical event terms list was present.Secondly, we determined the proportion of reports submitted by the individual groups to signals, in a cross‐sectional manner.ResultsA total of 150 signals were included, including 1691 ADR reports. Our results show that 26.3% of all ADR reports in Dutch drug safety signals were reported by patients, and 30.5% of the patient reports in the signals contained one or more terms listed as important medical events. The proportion of reports by patients which were included the signals was 2% and 3.9% for health care professional reports and 0.2% for marketing authorization holders reports.ConclusionPatients had an important contribution to signals overall, but especially for ADRs related to generic drug substitution and psychiatric ADRs.
Clinical trial allocation in multinational pharmaceutical companies – a qualitative study on influential factors
Authors: Dombernowsky Tilde , Haedersdal Merete , Lassen Ulrik , Thomsen Simon F. 
Published: May 2017

AbstractClinical trial allocation in multinational pharmaceutical companies includes country selection and site selection. With emphasis on site selection, the overall aim of this study was to examine which factors pharmaceutical companies value most when allocating clinical trials. The specific aims were (1) to identify key decision makers during country and site selection, respectively, (2) to evaluate by which parameters subsidiaries are primarily assessed by headquarters with regard to conducting clinical trials, and (3) to evaluate which site‐related qualities companies value most when selecting trial sites. Eleven semistructured interviews were conducted among employees engaged in trial allocation at 11 pharmaceutical companies. The interviews were analyzed by deductive content analysis, which included coding of data to a categorization matrix containing categories of site‐related qualities. The results suggest that headquarters and regional departments are key decision makers during country selection, whereas subsidiaries decide on site selection. Study participants argued that headquarters primarily value timely patient recruitment and quality of data when assessing subsidiaries. The site‐related qualities most commonly emphasized during interviews were study population availability, timely patient recruitment, resources at the site, and site personnel's interest and commitment. Costs of running the trials were described as less important. Site personnel experience in conducting trials was described as valuable but not imperative. In conclusion, multinational pharmaceutical companies consider recruitment‐related factors as crucial when allocating clinical trials. Quality of data and site personnel's interest and commitment are also essential, whereas costs seem less important. While valued, site personnel experience in conducting clinical trials is not imperative.
Cost–benefit analysis of controlling the spotted wing drosophila (Drosophila suzukii (Matsumura)) spread and infestation of soft fruits in Trentino, Northern Italy
Authors: Del Fava Emanuele , Ioriatti Claudio , Melegaro Alessia 
Published: May 2017

AbstractBACKGROUNDWe assessed the economic impact of the invasive pest Drosophila suzukii (Matsumura) on the soft fruit industry (strawberries, raspberries, blackberries and blueberries) in Trentino, Northern Italy, using cost–benefit analysis. A conventional integrated pest management (IPM) based on insecticide, mass trapping and cultural measures is compared with an upgraded IPM strategy based on exclusion netting. Costs and benefits associated with the change between the two are estimated to evaluate the most profitable strategy from a societal point of view. The robustness of the results to uncertainty in parameter values is assessed through probabilistic sensitivity analysis.RESULTSIn a period of low pest pressure, the conventional IPM strategy would likely be more profitable than no management. However, with higher pest pressure levels, the upgraded IPM strategy would increasingly be more profitable than conventional IPM as pest damage levels increase.CONCLUSIONFor the problem considered in this study, insecticide‐based management is expected to prove less and less profitable as rising pest pressure levels lead to an intensification of the insecticide applications. Conversely, exclusion netting, despite being more expensive, is expected to be much more profitable, in terms of both its effectiveness in reducing pest pressure and its lower societal impact. © 2017 Society of Chemical Industry