bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of prehabilitation in gastro-oesophageal adenocarcinoma: study protocol of a multicentric, randomised, control trial—the PREHAB study
Authors: Le Roy Bertrand , Pereira Bruno , Bouteloup Corinne , Costes Frédéric , Richard Ruddy , Selvy Marie , Pétorin Caroline , Gagnière Johan , Futier Emmanuel , Slim Karem , Meunier Bernard , Mabrut Jean-Yves , Mariette Christophe , Pezet Denis 
Published: December 2016

IntroductionPerioperative chemotherapy is the gold standard treatment of the resectable gastro-oesophageal adenocarcinoma. However, 70% of patients cannot receive the complete sequence because of a postoperative complication or a decrease in functional and nutritional reserves. Recently, a new concept appeared in digestive surgery: prehabilitation. This interventional process consists of patient preparation, between surgical consultation and surgery, and is based on 3 components: (1) physical management, (2) nutritional care and (3) psychological care. Prehabilitation should decrease postoperative complications and improve nutritional and physical status during the preoperative and postoperative periods. Therefore, it is becoming essential to evaluate the effect of prehabilitation, compared to conventional care, on the percentage of patients reaching the complete oncological treatment.Methods and analysisThe PREHAB trial aimed to evaluate the efficacy of prehabilitation compared to conventional care, in patients with gastro-oesophageal cancer with perioperative chemotherapy. This trial is a prospective, randomised, controlled, open-blind and interventional study in 4 centres. Patients (n=60 per group) will be randomly assigned for management with either prehabilitation or conventional care. The primary outcome is the percentage of patients reaching the complete oncological treatment decided in a multidisciplinary tumour board. The secondary outcomes are the postoperative morbidity, disease-free survival, overall survival, feasibility of the protocol, length of stay, variation of the functional reserve after the preoperative chemotherapy (defined by the VO2peak, ventilatory threshold and 6-min walk test), preoperative and postoperative nutritional status, preoperative anxiety, quality of life, 30-day and 90-day mortality and cumulative dose of cytotoxic treatment received.Ethics and disseminationThe study was approved by an independent medical ethics committee (IRB00008526, CPP Sud-Est VI, Clermont-Ferrand, France) and by the competent French authority (ANSM, Saint Denis, France) and registered onClinicaltrial.gov. The results will be disseminated in a peer-reviewed journal.Trial registration numberNCT02780921.
Differences among primary care patients with different mechanical patterns of low back pain: a cross-sectional investigation
Authors: Della Mora Lauren S , Perruccio Anthony V , Badley Elizabeth M , Rampersaud Y Raja 
Published: December 2016

ObjectivesTo characterise and compare a persistent low back pain (LBP) population based on 4 clinical pain patterns.DesignCross-sectional analysis of patient-reported data.SettingPatients from 220 primary care practitioners in 3 cities in Ontario, Canada.Participants1020 individuals seeking LBP care. Inclusion criteria: LBP symptoms lasting 1½–12 months, or unmanageable recurrent symptoms; ages 18+years. Exclusion criteria: pregnant/1-year postpartum; involved in active litigation or motor vehicle injury; emergent spinal presentations; pain disorder diagnosis; work injury claim; or constant symptoms persisting >12 months postonset.Main outcome measureHall pain pattern subgroups: back dominant pain aggravated by flexion (P1) or extension (P2), or leg dominant constant (P3) or intermittent (P4) pain (multinomial logistic outcome; referent: P1).ResultsGroups P1 and P2 had the highest proportion of women. P2 and P4 had higher mean ages and comorbidity counts. P3 and P4 had higher proportions of overweight/obese individuals and lower general health scores. Adjusted models: being male and overweight/obese was associated with increased odds of being in P3 (OR 1.64 (95% CI 1.10 to 2.46), and OR 1.74 (1.13 to 2.68), respectively) and P4 (OR 1.87 (1.11 to 3.15) and OR 1.91 (1.06 to 3.42), respectively), and increasing age with increased odds of being in P2 (OR 1.02 (1.01 to 1.03)) and P4 (OR 1.06 (1.04 to 1.08)). Increasing comorbidity count was associated with increased odds of being in P2 (OR 1.14 (1.0 to 1.3)), and better general health scores with decreased odds of being in P3 (OR 0.40 (0.18 to 0.93)).ConclusionsThis is the first study to examine the ‘Hall system’ in a non-rehab primary care population. Subgroups classified according to this system appear to have distinct profiles. Further research is needed to better characterise and determine the prognostic implication of these clinically derived subgroups.
Development of a model of dementia support and pathway for culturally and linguistically diverse communities using co-creation and participatory action research
Authors: Goeman Dianne , King Jordan , Koch Susan 
Published: December 2016

ObjectiveTo develop an inclusive model of culturally sensitive support, using a specialist dementia nurse (SDN), to assist people with dementia from culturally and linguistically diverse (CALD) communities and their carers to overcome barriers to accessing health and social care services.DesignCo-creation and participatory action research, based on reflection, data collection, interaction and feedback from participants and stakeholders.SettingAn SDN support model embedded within a home nursing service in Melbourne, Australia was implemented between October 2013 and October 2015.ParticipantsPeople experiencing memory loss or with a diagnosis of dementia from CALD backgrounds and their carers and family living in the community setting and expert stakeholders.Data collection and analysisReflections from the SDN on interactions with participants and expert stakeholder opinion informed the CALD dementia support model and pathway.ResultsInteraction with 62 people living with memory loss or dementia from CALD backgrounds, carers or family members receiving support from the SDN and feedback from 13 expert stakeholders from community aged-care services, consumer advocacy organisations and ethnic community group representatives informed the development and refinement of the CALD dementia model of care and pathway. We delineate the three components of the ‘SDN’ model: the organisational support; a description of the role; and the competencies needed. Additionally, we provide an accompanying pathway for use by health professionals delivering care to consumers with dementia from CALD backgrounds.ConclusionsOur culturally sensitive model of dementia care and accompanying pathway allows for the tailoring of health and social support to assist people from CALD backgrounds, their carers and families to adjust to living with memory loss and remain living in the community as long as possible. The model and accompanying pathway also have the potential to be rolled out nationally for use by health professionals across a variety of health services.
Quantifying the hospitalised morbidity and mortality attributable to traumatic injury using a population-based matched cohort in Australia
Authors: Mitchell Rebecca J , Cameron Cate M , McClure Rod 
Published: December 2016

ObjectivesTo quantify the 12-month hospitalised morbidity and mortality attributable to traumatic injury using a population-based matched cohort in Australia.SettingNew South Wales, Queensland and South Australia, Australia.ParticipantsIndividuals ≥18 years who had an injury-related hospital admission in 2009 formed the injured cohort. The non-injured comparison cohort was randomly selected from the electoral roll and was matched 1:1 on age, gender and postcode of residence at the date of the index injury admission of their matched counterpart.Primary outcome measuresUsing linked emergency department presentation, hospital admission and mortality records from 1 January 2008 to 31 December 2010 for both the injured and non-injured cohorts, 12-month mortality and pre-index and post-index injury hospital service use was examined. Adjusted rate ratios and attributable risk were calculated.ResultsThere were 167 600 individuals injured in 2009 and admitted to hospital in New South Wales, South Australia or Queensland with a matched comparison. The injured cohort had 3 times higher proportion of having ≥1 comorbidity preinjury, higher preinjury hospital service use, and a higher 12-month mortality compared with a non-injured comparison group. The injured cohort had 2.20 (95% CI 2.12 to 2.28) times higher rate of hospital admissions in the 12 months post the index injury admission compared with the non-injured comparison cohort. Injury was a likely contributory factor in at least 55% of hospitalisations within 12 months of the index injury hospitalisation.ConclusionsIndividuals who had an injury-related hospitalisation had higher mortality and are hospitalised at increased rates for many months postinjury. While comorbid conditions are significant, they do not account for the differences in outcomes. This study contributes to informing research efforts on better quantifying the attributable burden of hospitalised injury-related disability and mortality in Australia.
Th9 cytokines response and its possible implications in the immunopathogenesis of leprosy
Authors: de Sousa Jorge Rodrigues , Pagliari Carla , de Almeida Dandara Simone Maia , Barros Luiz Fernando Lima , Carneiro Francisca Regina Oliveira , Dias Leonidas Braga , de Souza Aarão Tinara Leila , Quaresma Juarez Antonio Simões 
Published: December 2016

AimsLeprosy is an infectious-contagious disease whose clinical evolution depends on the interaction of the infectious agent with the immune response of the host, leading to a clinical spectrum that ranges from lepromatous leprosy (susceptibility, LL) to tuberculoid leprosy (resistance, TT). The immune response profile will depend on the pattern of cytokine production and on the activity of macrophages during infection. Classically, the clinical evolution of leprosy has been associated with Th1/Th2 cytokine profiles, but the role of new cytokine profiles such as T helper 9 (Th9) remains to be elucidated.MethodsTo evaluate the tissue expression profile of these cytokines, a cross-sectional study was conducted using a sample of 30 leprosy skin lesion biopsies obtained from patients with leprosy, 16 TT and 14 lepromatous LL.ResultsImmunohistochemical analysis revealed a significant difference in interleukin (IL)-9, IL-4 transforming growth factor (TGF)-β and IL-10 levels between the two groups. IL-9 was more expressed in TT lesions compared with LL lesions. Higher expression of IL-4, IL-10 and TGF-β was observed in LL compared with TT. IL-4, IL-10 and TGF-β tended to be negatively correlated with the expression of IL-9, indicating a possible antagonistic activity in tissue.ConclusionsThe results suggest that Th9 lymphocytes may be involved in the response toMycobacterium leprae, positively or negatively regulating microbicidal activity of the local immune system in the disease.
Cosmological aspects of a unified dark energy and dust dark matter model
Authors: Staicova Denitsa , Stoilov Michail 
Published: December 2016

Recently, a model of modified gravity plus single scalar field was proposed, in which the scalar couples both to the standard Riemannian volume form given by the square root of the determinant of the Riemannian metric, as well as to another non-Riemannian volume form given in terms of an auxiliary maximal rank antisymmetric tensor gauge field. This model provides an exact unified description of both dark energy (via dynamically generated cosmological constant) and dark matter (as a “dust” fluid due to a hidden nonlinear Noether symmetry). In this paper, we test the model against Supernovae type Ia experimental data and investigate the future Universe evolution which follows from it. Our results show that this model has very interesting features allowing various scenarios of Universe evolution and in the same time perfectly fits contemporary observational data. It can describe exponentially expanding or finite expanding Universe and moreover, a Universe with phase transition of first kind. The phase transition occurs to a new, emerging at some time ground state with lower energy density, which affects significantly the Universe evolution.
Crystalline phase transformation of colloidal cadmium sulfide nanocrystals
Authors: Ghali M. , Eissa A. M. , Mosaad M. M. 
Published: December 2016

In this paper, we give a microscopic view concerning influence of the growth conditions on the physical properties of nanocrystals (NCs) thin films made of CdS, prepared using chemical bath deposition CBD technique. We show a crystalline phase transformation of CdS NCs from hexagonal wurtzite (W) structure to cubic zincblende (ZB) when the growth conditions change, particularly the solution pH values. This effect was confirmed using X-ray diffraction (XRD), transmission electron microscopy (TEM), optical absorption and photoluminescence (PL) measurements. The optical absorption spectra allow calculation of the bandgap value, [Formula: see text], where significant increase [Formula: see text]200 meV in the CdS bandgap when transforming from Hexagonal to Cubic phase was found.
Mixed magnetic exchange interactions and ferromagnetic diffuse phase transition of La1−xMnO3+δ manganites
Authors: Zhang W. C. , Zhang A. M. , Zhang X. , Zhou G. T. , Wu X. S. 
Published: December 2016

Effects of vacancy on the microstructural and magnetic properties in self-doped La[Formula: see text]MnO[Formula: see text] [Formula: see text] manganites have been studied. The samples crystallize in a single phase of rhombohedral structure exhibiting R[Formula: see text]C space group until [Formula: see text]-value reaches 0.2. As self-doped concentration increases, structural distortion is confirmed by combining X-ray diffraction. Ferromagnetic (FM) and antiferromagnetic (AFM) coupling is found and exchange bias effect appears at low temperature. Ferromagnetic diffuse phase transition (FDPT) is induced by Griffiths phase for [Formula: see text] at temperature of [Formula: see text]. The FM transition temperature range is increased from 32 K to 150 K. The enhancement of Griffiths phase with [Formula: see text] for [Formula: see text] is explained by the greater [Formula: see text]-site spatial disorder and the structural distortion.
Ferroelectric properties in all solution prepared Bi6Fe2Ti3O18/Ba0.92La0.08SnO3 thin films
Authors: Zhang Li , Li Yibao , Tang Zhen , Deng Yan , Yuan Hui , Yu Jiangying , Zhu Xuebin 
Published: December 2016

In this paper, all solution processing is used to prepare both the transparent conducting Ba[Formula: see text]La[Formula: see text]SnO3 (BLSO) thin films as bottom electrodes and ferroelectric Bi6Fe2Ti3O[Formula: see text] (BFTO) thin films. The derived BFTO thin films are characterized by X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM). The derived thin film is polycrystalline with dense microstructures. The remnant polarization [Formula: see text] at the measurement frequency of 2 kHz can reach [Formula: see text] under the 500 kV/cm electric field and the coercive field [Formula: see text] is 410 kV/cm. The results will provide a feasible route to prepare BFTO thin films on transparent conducting bottom electrodes to realize multifunctionality.
Computational modeling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1
Authors: Fong Shelley , Chiorini John A , Sneyd James , Suresh Vinod 
Published: December 2016

Previous studies have shown that localized delivery of the aquaporin-1 (AQP1) gene to the parotid duct can restore saliva flow in minipigs following irradiation-induced salivary hypofunction. The resulting flow rate and electrochemistry of secreted saliva contradicts current understanding of ductal fluid transport. We hypothesized that changes in expression of ion transport proteins have occurred following AQP1 transfection. We use a mathematical model of ion and fluid transport across the parotid duct epithelial cells to predict the expression profile of ion transporters that are consistent with the experimental measurements of saliva composition and secretion rates. Using a baseline set of parameters, the model reproduces the data for the irradiated, non-AQP1-transfected case. We propose three scenarios which may have occurred after transfection, which differ in the location of the AQP1 gene. The first scenario places AQP1 within nonsecretory cells, and requires that epithelial sodium channel (ENaC) expression is greatly reduced (1.3% of baseline), and ductal bicarbonate concentration is increased from 40.6 to 137.0 mM, to drive water secretion into the duct. The second scenario introduces the AQP1 gene into all ductal cells. The final scenario has AQP1 primarily in the proximal duct cells which secrete water under baseline conditions. We find the change in the remaining cells includes a 95.8% reduction in ENaC expression, enabling us to reproduce all experimental ionic concentrations within 9 mM. These findings provide a mechanistic basis for the observations and will guide the further development of gene transfer therapy for salivary hypofunction. NEW & NOTEWORTHY Following transfection of aquaporin into the parotid ducts of minipigs with salivary hypofunction, the resulting increase in salivary flow rates contradicts current understanding of ductal fluid transport. We show that the change in saliva electrochemistry and flow rate can be explained by changes in expression of ion transporters in the ductal cell membranes, using a mathematical model replicating a single parotid duct.
BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes
Authors: Greenhalgh Katie A. , Strachan Mark W. , Alzahrani Saad , Baxter Paul D. , Standeven Kristina F. , Storey Robert F. , Ariens Robert A. S. , Grant Peter J. , Price Jackie F. , Ajjan Ramzi A. 
Published: December 2016

SummaryBoth type 2 diabetes (T2DM) and Bß448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BßArg448Lys adds to vascular risk by modulating fibrin network structure and/or fibrinolysis in diabetes. The primary aim was to study effects of BßArg448Lys on fibrin network characteristics in T2DM. Secondary aims investigated interactions between gender and BßArg448Lys substitution in relation to fibrin clot properties and vascular disease. Genotyping for BßArg448Lys and dynamic clot studies were carried out on 822 T2DM patients enrolled in the Edinburgh Type 2 Diabetes Study. Turbidimetric assays of individual plasma samples analysed fibrin clot characteristics with additional experiments conducted on clots made from purified fibrinogen, further examined by confocal and electron microscopy. Plasma clot lysis time in Bß448Lys was longer than Bß448Arg variant (mean ± SD; 763 ± 322 and 719 ± 351 seconds [s], respectively; p<0.05). Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 ± 8.07, 38.40 ± 6.04 and 25 ± 4.99 nm, respectively; p<0.001) and clot lysis time (419 ± 64, 442 ± 87 and 517 ± 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes. Women with Bß448Lys genotype had increased risk of cerebrovascular events and were younger compared with Bß448Arg variant (67.2 ± 4.0 and 68.2 ± 4.4 years, respectively; p=0.035). In conclusion, fibrinogen Bβ448Lys variant is associated with thrombotic fibrin clots in diabetes independently of traditional risk factors. Prospective studies are warranted to fully understand the role of BβArg448Lys in predisposition to vascular ischaemia in T2DM with the potential to develop individualised antithrombotic management strategies.
Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans
Authors: Lallukka Susanna , Luukkonen Panu K. , Zhou You , Isokuortti Elina , Leivonen Marja , Juuti Anne , Hakkarainen Antti , Orho-Melander Marju , Lundbom Nina , Olkkonen Vesa M. , Lassila Riitta , Yki-Järvinen Hannele 
Published: December 2016

SummaryIncreased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT), activities of several coagulation factors, VWF:RCo and fibrinogen, and D-dimer concentration in 92 subjects divided into groups based on insulin sensitivity [insulin-resistant (‘IR’) versus insulin-sensitive (‘IS’)] and PNPLA3 genotype (PNPLA3148MM/MI vs PNPLA3148II). Liver fat content (1H-MRS) was similarly increased in ‘IR’ (13 ± 1 %) and PNPLA3148MM/MI (12 ± 2 %) as compared to ‘IS’ (6 ± 1 %, p < 0.05) and PNPLA3148II (8 ± 1 %, p < 0.05), respectively. FVIII, FIX, FXIII, fibrinogen and VWF:RCo activities were increased, and PT and APTT shortened in ‘IR’ versus ‘IS’, in contrast to these factors being similar between PNPLA3148MM/MI and PNPLA3148II groups. In subjects undergoing a liver biopsy and entirely lacking the I148M variant, insulin-resistant subjects had higher hepatic expression of F8, F9 and FGG than equally obese insulin-sensitive subjects. Expression of pro-inflammatory genes in adipose tissue correlated positively with PT (% of normal), circulating FVIII, FIX, FXI, VWR:RCo and fibrinogen, and expression of anti-inflammatory genes negatively with PT (%), FIX and fibrinogen. We conclude that obesity/insulin resistance rather than an increase in liver fat is associated with a procoagulant plasma profile. This reflects adipose tissue inflammation and increased hepatic production of coagulation factors and their susceptibility for activation.Supplementary Material to this article is available online at www.thrombosis-online.com.