bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter prospective study on the diagnostic performance of a new liquid rapid urease test for the diagnosis of Helicobacter pylori infection
Authors: Dolak Werner , Bilgilier Ceren , Stadlmann Alexander , Leiner Judith , Püspök Andreas , Plieschnegger Wolfgang , Siebert Franz , Wewalka Friedrich , Schöfl Rainer , Huber-Schönauer Ursula , Datz Christian , Biowski-Frotz Susanne , Högenauer Christoph , Schrutka-Kölbl Christiane , Makristathis Athanasios , Schöniger-Hekele Maximilian , Steininger Christoph ,   for the Austrian Helicobacter Pylori Study Group
Published: December 2017

Abstract
Background
Helicobacter pylori (H. pylori) causes a diversity of gastric diseases. Rapid urease tests (RUT) are well established for the point-of-care, invasive diagnosis of H. pylori infection. The study aimed to evaluate the diagnostic performance of a new liquid RUT, the preOx-HUT, within a prospective cohort of treatment-naïve patients.

Methods
The multicenter prospective clinical trial was conducted at nine Austrian centers for gastrointestinal endoscopy. Patients referred for a diagnostic upper gastrointestinal endoscopy underwent gastric biopsy sampling for routine histological evaluation, and in parallel, the preOx-HUT. Histology served as reference standard to evaluate the diagnostic performance of the preOx-HUT.

Results
From January 2015 to January 2016, a total of 183 consecutive patients (54 males and 129 females, median age 50 years) were included. Endoscopy revealed pathological findings in 149/183 cases (81%), which were mostly gastritis (59%) and gastro-esophageal reflux disease (27%). H. pylori infection was detected by histology in 41/183 (22%) cases. In relation to histology, the preOx-HUT had a sensitivity of 85%, a specificity of 94%, a positive predictive value of 80% and a negative predictive value of 96%. Performance of preOx-HUT was not affected significantly by concomitant PPI-use as present in 15% of cases (P = 0.73).

Conclusions
This was the first study evaluating the preOx-HUT in a prospective, multicenter clinical setting. We found a high diagnostic accuracy for the point-of-care, invasive diagnostic test of H. pylori infection. Hence, this test may be a valuable diagnostic adjunct to the clinical presentation of patients with suspected H. pylori infection.
Trial registration number EK 1548/2014, Name of registry: Register der Ethikkommission der Medizinischen Universität Wien, URL of registry: https://ekmeduniwien.at/core/catalog/2012/, Date of registration: 24.09.2014, Date of enrolment of the first participant to the trial: 15.01.2015
Compact Planar One-Shot Circular Spark Gap Switch
Authors: Gupta Harish Kumar , Patel M R , Sharma Sahil , Nirmal A V , Singh Kamaljeet 
Published: December 2017

<p class="p1">The fabrication and characterisation of micro spark gap switch for single shot firing applications are given in detailed . A circular switch with triggering electrode is realised on alumina substrate and can be integratable easily with the electronics for ignition applications. Circular switch is realised on 25 mil alumina substrate within substrate diameter of 10 mm. The switch measurement shows having repeatable performance of pulse peak current of around 2000 A and less than 100 ns rise time. This article details the design, development including fabrication aspects of spark switch with trigger capabilities along with characterisation of switch on alumina substrates.<span class="Apple-converted-space"> </span></p>
Mathematical Modeling of Actinidia arguta (Kiwiberry) Drying Kinetics
Authors: Bialik Michał , Gondek Ewa , Wiktor Artur , Latocha Piotr , Witrowa-Rajchert Dorota 
Published: December 2017

Abstract
Consumers and scientists exhibit a growing interest in bioactive ingredients of natural origin with strong pro-health effects. Such properties have been found in fruits of of Actinidia argute, commonly known as kiwiberry (mini kiwi or hardy kiwi). Appropriate methods and parameters of the drying process enable obtaining a product with preserved high pro-health properties. The obejctive of this paper was to study the influence of the selected drying methods on the drying kinetics of actinidia. Commonly known mathematical models were used to describe the process. The kinetics of convective, microwave-convective, infrared and vacuum drying was investigated. The process was performed until samples reached dimensionless moisture ratio (MR) of 0.02. The quickest method was vacuum drying reaching moisture ratio target after 286 min, and the slowest was convective drying characterized by 1352 min of drying. In general, Midilli et al.’s model was evaluated as the most adequate for description of the moisture transfer in the fruit samples.
Using counterfactuals to display facts – the case of satirical humor
Authors: Maslo Adi 
Published: December 2017

Abstract
Satire has not been given the humorologists’ attention to an extent that would do justice to the amount of humor satire actually holds. Therefore, the intention of this paper is to shed light on satire as humorous discourse, with an emphasis on counterfactuals. Interestingly enough, counterfactuals oppose the actual state of affairs; rhetorically however, they show potential to reveal the truth. Political satire is an area of conflict between truth and falsehood which is exactly why this type of satire is discussed in this paper. Tools from Cognitive Linguistics – framing and blending – are utilized to show to what extent counterfactuals are actually false and how they essentially contribute to satire. Examples of political satire are selected from Comedy Central’s The Daily Show.
Metformin-induced anticancer activities: recent insights
Authors: Safe Stephen , Nair Vijayalekshmi , Karki Keshav 
Published: December 2017

AbstractMetformin is a widely used antidiabetic drug, and there is evidence among diabetic patients that metformin is a chemopreventive agent against multiple cancers. There is also evidence in human studies that metformin is a cancer chemotherapeutic agent, and several clinical trials that use metformin alone or in combination with other drugs are ongoing.In vivoandin vitrocancer cell culture studies demonstrate that metformin induces both AMPK-dependent and AMPK-independent genes/pathways that result in inhibition of cancer cell growth and migration and induction of apoptosis. The effects of metformin in cancer cells resemble the patterns observed after treatment with drugs that downregulate specificity protein 1 (Sp1), Sp3 and Sp4 or by knockdown of Sp1, Sp3 and Sp4 by RNA interference. Studies in pancreatic cancer cells clearly demonstrate that metformin decreases expression of Sp1, Sp3, Sp4 and pro-oncogenic Sp-regulated genes, demonstrating that one of the underlying mechanisms of action of metformin as an anticancer agent involves targeting of Sp transcription factors. These observations are consistent with metformin-mediated effects on genes/pathways in many other tumor types.
Re-reading the Religious – Aesthetically: A Literary Analysis of “The Woman Who Was a Sinner” and The Lily in the Field and the Bird of the Air
Authors: Fürstenberg Henrike 
Published: December 2017

AbstractAlthough Kierkegaard is known to express himself extraordinarily eloquently, at first glance this doesn’t seem to apply to his decidedly religious writings, which appear rather monotonous in many cases. This impression might lead to a one-sided interpretation of the significance of aesthetic devices and aesthetic approaches in Kierkegaard’s works. However, close literary readings of his religious writings reveal to which extent the religious texts are not only committed to ‘the aesthetic’ by applying, integrating and contradicting it-but that they even depend on it with regard to their own functioning.
A Promise Kept, a Self Repeated? Reading Gjentagelsen with Ricoeur
Authors: Becker-Lindenthal Hjördis 
Published: December 2017

AbstractBased on Paul Ricoeur’s concept of ipseity and the role of promising for constituting selfhood as non-identical permanence in time, the article revisits the controversy whether or not the young man in Repetition experiences a repetition of the self. Considering Hans Lipps’s notion of the radical openness of a promise based on solicitude as much as Ricoeur’s “fundamental promise” to be faithful to oneself, two different perspectives are provided in order to interpret the young man’s break with his fiancée. According to both perspectives it can coherently be claimed that in the realm of ethical selfhood as depicted by Ricoeur in Oneself as Another and The Course of Recognition, the young man non-identically repeats his self.
LpSpaces in vector lattices and applications
Authors: Boccuto Antonio , Candeloro Domenico , Sambucini Anna Rita 
Published: December 2017

AbstractLpspaces are investigated for vector lattice-valued functions, with respect to filter convergence. As applications, some classical inequalities are extended to the vector lattice context, and some properties of the Brownian motion and the Brownian bridge are studied, to solve some stochastic differential equations.
Direct monitoring of erythrocytes aggregation under the effect of the low-intensity magnetic field by measuring light transmission at wavelength 800 nm
Authors: Elblbesy Mohamed A. 
Published: December 2017

Abstract
Interacting electromagnetic field with the living organisms and cells became of the great interest in the last decade. Erythrocytes are the most common types of the blood cells and have unique rheological, electrical, and magnetic properties. Aggregation is one of the important characteristics of the erythrocytes which has a great impact in some clinical cases. The present study introduces a simple method to monitor the effect of static magnetic field on erythrocytes aggregation using light transmission. Features were extracted from the time course curve of the light transmission through the whole blood under different intensities of the magnetic field. The findings of this research showed that static magnetic field could influence the size and the rate of erythrocytes aggregation. The strong correlations confirmed these results between the static magnetic field intensity and both the time of aggregation and sedimentation of erythrocytes. From this study, it can be concluded that static magnetic field can be used to modify the mechanisms of erythrocytes aggregation.
Application of graph theory to the morphological analysis of settlements
Authors: Szmytkie Robert 
Published: December 2017

AbstractIn the following paper, the analyses of morphology of settlements were conducted using graph methods. The intention of the author was to create a quantifiable and simple measure, which, in a quantitative way, would express the degree of development of a graph (the spatial pattern of settlement). When analysing examples of graphs assigned to a set of small towns and large villages, it was noticed that the graph development index should depend on: a relative number of edges in relation to the number of nodes (β index), the number of cycles (urban blocks), which evidences the complexity of the spatial pattern of settlement, and the average rank of nodes of a graph, which expresses the degree of complexity of a street network.
Food insecurity as a basis for drafting a Strategic Food Sovereignty Plan: A case study of the Kutai Kartanegara District, Indonesia
Authors: Subejo  , Fidiashtry Al , Aryudiawan Candra , Suadi  , Awaluddin L , Marfai Muh Aris 
Published: December 2017

Abstract
This study aims to analyse food sovereignty strategies in an effort to eradicate poverty in a micro-scale region by strengthening its food security status. The research was conducted in the Kutai Kartanegara District East Kalimantan Province in Indonesia. Food insecurity status in the study area was determined based on nine food security indicators. The 237 villages in the Kutai Kartanegara District were ranked based on four classifications of vulnerability to food insecurity. The results showed that 3.80% of the villages were highly vulnerable, 5.06% were vulnerable, 8.86% were slightly vulnerable and 82.28% were food secure. While Kutai Kartanegara was a food secure district, in order to maintain its food security status and enhance the performance of the villages that are still vulnerable to food insecurity, local government, and related stakeholders must work together to develop strategies to improve agricultural productivity, increase the region’s human resources capability and strengthen its infrastructure so food can be more readily accessed.
Tenuous Inhibitory GABAergic Signaling in the Reticular Thalamus
Authors: Klein Peter M. , Lu Adam C. , Harper Megan E. , McKown Hannah M. , Morgan Jessica D. , Beenhakker Mark P. 
Published: December 2017

Maintenance of a low intracellular Cl−concentration ([Cl−]i) is critical for enabling inhibitory neuronal responses to GABAAreceptor-mediated signaling. Cl−transporters, including KCC2, and extracellular impermeant anions ([A]o) of the extracellular matrix are both proposed to be important regulators of [Cl−]i. Neurons of the reticular thalamic (RT) nucleus express reduced levels of KCC2, indicating that GABAergic signaling may produce excitation in RT neurons. However, by performing perforated patch recordings and calcium imaging experiments in rats (male and female), we find that [Cl−]iremains relatively low in RT neurons. Although we identify a small contribution of [A]oto a low [Cl−]iin RT neurons, our results also demonstrate that reduced levels of KCC2 remain sufficient to maintain low levels of Cl−. Reduced KCC2 levels, however, restrict the capacity of RT neurons to rapidly extrude Cl−following periods of elevated GABAergic signaling. In a computational model of a local RT network featuring slow Cl−extrusion kinetics, similar to those we found experimentally, model RT neurons are predisposed to an activity-dependent switch from GABA-mediated inhibition to excitation. By decreasing the activity threshold required to produce excitatory GABAergic signaling, weaker stimuli are able to propagate activity within the model RT nucleus. Our results indicate the importance of even diminished levels of KCC2 in maintaining inhibitory signaling within the RT nucleus and suggest how this important activity choke point may be easily overcome in disorders such as epilepsy.SIGNIFICANCE STATEMENTPrecise regulation of intracellular Cl−levels ([Cl−]i) preserves appropriate, often inhibitory, GABAergic signaling within the brain. However, there is disagreement over the relative contribution of various mechanisms that maintain low [Cl−]i. We found that the Cl−transporter KCC2 is an important Cl−extruder in the reticular thalamic (RT) nucleus, despite this nucleus having remarkably low KCC2 immunoreactivity relative to other regions of the adult brain. We also identified a smaller contribution of fixed, impermeant anions ([A]o) to lowering [Cl−]iin RT neurons. Inhibitory signaling among RT neurons is important for preventing excessive activation of RT neurons, which can be responsible for generating seizures. Our work suggests that KCC2 critically restricts the spread of activity within the RT nucleus.
Flexible nasoendoscopy decontamination: a comparison between Rapicide and Tristel wipes, a prospective cohort study
Authors: Gan Yijin Jereme , Mathews Alex , Chuqin Phua , Khoo Ivan , Loke David 
Published: December 2017

<p class="abstract"><strong>Background:</strong> The current disinfection of nasoendoscopes in our clinic setting is a 3-step process involving Rapicide, a peracetic acid based disinfectant. Our study aimed to validate the efficacy of Tristel wipes, a chlorine dioxide based disinfectant, as a comparable alternative.</p><p class="abstract"><strong>Methods:</strong> We recruited a hundred volunteers undergoing routine flexible nasoendoscopic examinations in a general ENT. We used two separate endoscopes for each examination, following which a microbiological swab was sent from the tip of each nasoendoscope. The two nasoendoscopes were then subjected to a similar 3-step decontamination process except for the second step, where they were disinfected either tristel wipes or rapicide disinfectant. After decontamination, we took a second swab from the tip of each nasoendoscope. </p><p class="abstract"><strong>Results:</strong> Out of 200 swabs from the tip of the nasoendoscopes prior to decontamination, there were 82 positive cultures for the Rapicide cohort and 76 positive cultures for the Tristel wipes cohort. Regarding the post decontamination results, there were four positive swab cultures for those disinfected with Tristel wipes and one positive swab culture for the Rapicide cohort. These were analyzed by the Z score and there was no statistical difference between either the pre-decontamination swabs or the post decontaminations swabs with the p-values at p=0.298 and p=0.174 respectively. The efficacy of decontamination for the Rapicide solution was 98.8% compared to 94.7% for the Tristel wipes with p=0.147.</p><strong>Conclusions:</strong>This study validates the efficacy of Tristel wipes as a comparable alternative to peracetic acid based disinfectants for disinfection of flexible nasoendoscopes.<p> </p>
Bilateral temporal bone fractures: a case report
Authors: Natarajan Kiran , Madhav Koka , Saraswathi A. V. , Kameswaran Mohan 
Published: December 2017

<p>Bilateral temporal bone fractures are rare; accounting for 9% to 20% of cases of temporal bone fractures. Clinical manifestations include hearing loss, facial paralysis, CSF otorhinorrhea and dizziness. This is a case report of a patient who presented with bilateral temporal bone fractures. This is a report of a 23-yr-old male who sustained bilateral temporal bone fractures and presented 18 days later with complaints of watery discharge from left ear and nose, bilateral profound hearing loss and facial weakness on the right side. Pure tone audiometry revealed bilateral profound sensori-neural hearing loss. CT temporal bones &amp; MRI scans of brain were done to assess the extent of injuries. The patient underwent left CSF otorrhea repair, as the CSF leak was active and not responding to conservative management. One week later, the patient underwent right facial nerve decompression. The patient could not afford a cochlear implant (CI) in the right ear at the same sitting, however, implantation was advised as soon as possible because of the risk of cochlear ossification. The transcochlear approach was used to seal the CSF leak from the oval and round windows on the left side. The facial nerve was decompressed on the right side. The House-Brackmann grade improved from Grade V to grade III at last follow-up. Patients with bilateral temporal bone fractures require prompt assessment and management to decrease the risk of complications such as meningitis, permanent facial paralysis or hearing loss. </p>
A rare case report of Eagle’s syndrome complicated with chronic mouth opening, its management and complete rehabilitation; dental perspective
Authors: Kumar A. Navin , Kumar Bhushan , Dua Gaurav , Mehta Sandeep 
Published: December 2017

<p>Eagle’s syndrome is a rare condition of either elongated styloid process or ossification of its ligaments; which is less appreciated and often ignored condition by clinicians because of its vague symptoms which can be easily confused with other oral or paraoral conditions presenting with similar signs and symptoms. Since it is not a routine clinical problem, it is not given the first priority thought while diagnosing such a case; especially in the absence of sound clinical knowledge and good radiographs. This article is aimed to summarize unusual clinical presentations, diagnosis and standardized tonsil-sparing trans-oral surgical approach for Eagle’s Syndrome case and its unique postoperative management. A<strong> </strong>80 years old female patient presented with the tendency of uncontrolled wide mouth opening with severe pain in both ears, temporal region; submandibular area extending up to back of neck with intensity on right side. The patient was diagnosed as a case of the Eagle’s syndrome with a unique finding of pain relief on wide mouth opening. The patient was operated for bilateral styloidectomy followed by postsurgical rehabilitation with custom made chin cup appliance and mouth opening exercises. </p>
A importância instrumental da sindicabilidade do serviço público prestado pelo Poder Judiciário no sopesamento dos direitos transindividuais / the instrumental importance of judicial stewardship as a public service aiming collective rights on balance
Authors: Bastianetto Lorena Machado Rogedo , Costa Beatriz Souza 
Published: December 2017

Resumo Este trabalho concentra seus esforços na análise do Recurso Extraordinário de n. 586.224/SP, com repercussão geral reconhecida e acórdão proferido no ano de 2015 com o objetivo de investigar toda a malha principiológica e legislativa suscitada na sentença colegiada para a fundamentação e elaboração da persuasão magistral. O embasamento do Supremo Tribunal Federal (STF) para a ideação expressa nos votos é a porta de entrada para a investigação de toda a metodologia e parâmetros lançados mão na formação do convencimento dos ministros, bem como das possíveis disfunções e vícios na intelectividade do pensamento. Como porta de saída, o artigo revela alternativas instrumentais para uma melhor gestão do mérito por meio do procedimento visando a um serviço público judicial mais protetivo, bem como aponta a periculosidade do adimplemento conteudista de princípios sem uma vivaz averiguação dos pilares múltiplos de participatividade cidadã. No desfecho, desborda-se o imperativo protagonismo da coletividade na produção da norma judicial e a relevância da ótica de gerenciamento processual. Palavras-chave: Direitos Transindividuais. Instrumentalidade. Jurisprudência. Serviço Público Judicial. Sindicabilidade. Abstract This paper focuses on the analysis of an Appeal to the Brazilian Supreme Court, RE # 586.224/SP, with acknowledged general interest and judgement published in the year of 2015. The main goal is investigate all the principles and legal diplomas arisen in the sentence claimed as grounds for its reasoning. The Supreme Court`s ground for sentencing was examined for the proper identification of parameters, methodologies and approach taken into account, as well as possible faults and vices in the construction of votes. The article aims to reveal alternative ways to file petitions and motions, what could lead to a better balance of rights and thus, to an enhancement of judicial guardianship. In conclusion, the comprehension of judicial activism must embrace citizenship and the awareness by the community of the relevance carried by an effective procedure management, as well as the fluidity of conceptual thesis about fundamental rights. Keywords: Collective Rights. Instrumentality. Judicial Public Service. Jurisprudence. Stewardship.