bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of miR‐497/EIF3A Axis in TGFβ1‐Induced Epithelial–Mesenchymal Transition and Extracellular Matrix in Rat Alveolar Epithelial Cells and Pulmonary Fibroblasts
Authors: Guo Ren , Lv Yu , Ouyang Yang , Liu Siyu , Li Dai 
Published: March 2017

ABSTRACTMulti‐cause‐induced interstitial lung disease, particularly pulmonary fibrosis, is a serious clinical concern. Fibroblasts have been suggested to have a major role, with it recently being revealed that some of these fibroblasts are derived from alveolar epithelial cells through epithelial–mesenchymal transition (EMT). Eukaryotic translation initiation factor 3 subunit A (EIF3A) is a protein that in humans is encoded by the EIF3A gene, and has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In the present study, we chose a well‐known TGFβ1‐induced EMT model in alveolar epithelial cells to investigate the functional role of EIF3A. TGFβ1‐induced EIF3A expression and EMT process in alveolar epithelial cells, after EIF3A knockdown, the EMT process could be partially reversed. Online tools and luciferase assays showed that miR‐497 could inhibit EIF3A expression by directly binding to the 3′UTR of EIF3A. Ectopic miR‐497 expression partially reversed TGFβ1‐induced EMT in alveolar epithelial cells. In addition, miR‐497 could suppress TGFβ1‐induced pulmonary fibroblast proliferation and EIF3A, Collagen I and α‐SMA protein levels. Taken together, EIF3A could promote TGFβ1‐induced EMT in alveolar epithelial cells; miR‐497 suppressed TGFβ1‐induced EMT in alveolar epithelial cells TGFβ1‐induced excessive proliferation and ECM in pulmonary fibroblast through inhibiting EIF3A by targeting. MiR‐497/EIF3A axis shows the potential to be effective in the treatment of pulmonary fibrosis. J. Cell. Biochem. 118: 3401–3408, 2017. © 2017 Wiley Periodicals, Inc.
Witnesses' failure to detect covert manipulations in their written statements
Authors: Sagana Anna , Sauerland Melanie , Merckelbach Harald 
Published: March 2017

AbstractLaw enforcement agencies and legal professionals often have to rely on witness statements. Undetected errors in witnesses' statements, however, could impede the accurate reconstruction of a crime and lead to the incrimination of innocent suspects. Here, we examined whether witnesses can detect manipulations in their written statements. We expect that writing a statement could provide a good means for discrimination between what is truly recalled and what is an error. This is because writing allows to monitor and control the previously produced information. In 3 experiments, participants watched a mock crime film and subsequently provided a written statement of what they had witnessed. Following a delay of several minutes (Experiment 1), 48 hr (Experiment 2), or 1 month (Experiment 3), participants were exposed to and interviewed about their testimony. Unknown to them, they were confronted with statements, which included 4 secretly manipulated details. Participants' missed a substantial number of manipulations in their written statements. Importantly, the detection rates varied as a function of delay (Experiments 1 and 2: 74–89%; Experiment 3: 36%–52%). Detection rates also varied as a function of the type of details that were manipulated. Our findings indicate that writing a statement comes with limited benefits in witnesses' ability to detect errors in their statements.
Preparation and evaluation of molecularly imprinted polymer for selective recognition and adsorption of gossypol
Authors: Zhi Keke , Wang Lulu , Zhang Yagang , Zhang Xuemin , Zhang Letao , Liu Li , Yao Jun , Xiang Wei 
Published: March 2017

AbstractMolecularly imprinted polymers (MIPs) were designed and prepared via bulk thermal polymerization with gossypol as the template molecule and dimethylaminoethyl methacrylate as the functional monomer. The morphology and microstructures of MIPs were characterized by scanning electron microscope and Brunauer‐Emmett‐Teller surface areas. Static adsorption tests were performed to evaluate adsorption behavior of gossypol by the MIPs. It was found that adsorption kinetics and adsorption isotherms data of MIPs for gossypol were fit well with the pseudo‐second‐order model and Freundlich model, respectively. Scatchard analysis showed that heterogeneous binding sites were formed in the MIPs, including lower‐affinity binding sites with the maximum adsorption of 252 mg/g and higher‐affinity binding sites with the maximum adsorption of 632 mg/g. Binding studies also revealed that MIPs had favorable selectivity towards gossypol compared with non‐imprinted polymers. Furthermore, adsorption capacity of MIPs maintained above 90% after 5 regeneration cycles, indicating MIPs were recyclable and could be used multiple times. These results demonstrated that prepared MIPs could be a promising functional material for selective adsorption of gossypol.
Synthesis of hydrophobic nanoparticles for real‐time lysozyme detection using surface plasmon resonance sensor
Authors: Saylan Yeşeren , Yılmaz Fatma , Derazshamshir Ali , Yılmaz Erkut , Denizli Adil 
Published: March 2017

AbstractDiagnostic biomarkers such as proteins and enzymes are generally hard to detect because of the low abundance in biological fluids. To solve this problem, the advantages of surface plasmon resonance (SPR) and nanomaterial technologies have been combined. The SPR sensors are easy to prepare, no requirement of labelling and can be detected in real time. In addition, they have high specificity and sensitivity with low cost. The nanomaterials have also crucial functions such as efficiency improvement, selectivity, and sensitivity of the detection systems. In this report, an SPR‐based sensor is developed to detect lysozyme with hydrophobic poly (N‐methacryloyl‐(L)‐phenylalanine) (PMAPA) nanoparticles. The SPR sensor was first characterized by attenuated total reflection‐Fourier transform infrared, atomic force microscope, and water contact angle measurements and performed with aqueous lysozyme solutions. Various concentrations of lysozyme solution were used to calculate kinetic and affinity coefficients. The equilibrium and adsorption isotherm models of interactions between lysozyme solutions and SPR sensor were determined and the maximum reflection, association, and dissociation constants were calculated by Langmuir model as 4.87, 0.019 nM−1, and 54 nM, respectively. The selectivity studies of SPR sensor were investigated with competitive agents, hemoglobin, and myoglobin. Also, the SPR sensor was used four times in adsorption/desorption/recovery cycles and results showed that, the combination of optical SPR sensor with hydrophobic ionizable PMAPA nanoparticles in one mode enabled the detection of lysozyme molecule with high accuracy, good sensivity, real‐time, label‐free, and a low‐detection limit of 0.66 nM from lysozyme solutions. Lysozyme detection in a real sample was performed by using chicken egg white to evaluate interfering molecules present in the medium.
Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study
Authors: Gao Xia , Chen Zhe , Liu Min , Jia Yu‐Mei , Yang Ning , Yao Zhi , Feng Xiao‐Meng , Xu Yuan , Wang Guang 
Published: March 2017

PurposeTo investigate using magnetic resonance imaging (MRI) myocardial injuries and cardiac function in patients with newly diagnosed severe primary overt hypothyroidism (HT) before and after achieving euthyroidism by short‐term levothyroxine treatment. Levothyroxine treatment improves cardiovascular performance and ventricular remodeling in patients with HT, but diffuse myocardial injuries induced by HT are difficult to detect clinically.Materials and MethodsMyocardial longitudinal relaxation time (T1) mapping using the modified Look–Locker inversion‐recovery (MOLLI) sequences at 3.0T was performed before and after euthyroidism was achieved by levothyroxine treatment in 24 patients with Hashimoto's thyroiditis, and compared to 17 healthy controls. Subjects underwent measurements of T1 values and left ventricular stroke volume (SV), ejection fraction (EF), cardiac index (CI), and peak filling rate (PFR). Cardiac data were expressed as an index, as per body surface area, except for heart rate and EF.ResultsPatients with untreated HT exhibited significantly longer native myocardial T1 values (all P < 0.05) accompanied by reduced SV (30.7 ± 5.6 vs. 34.9 ± 6.8 mL/m2, P < 0.05), CI (2.1 ± 0.4 vs. 2.4 ± 0.4 L/min/m2, P < 0.05), and PFR (3.5 ± 0.9 vs. 4.2 ± 1.1 EDV/s, P < 0.05) compared to healthy controls at baseline. Achieving euthyroidism resulted in a significant decrease in T1 values and improved SV, CI, and PFR values (all P < 0.05) in the patients with HT. Negative correlations of the T1 values with free triiodothyronine (r = –0.55, P < 0.001) and PFR (r = –0.46, P = 0.0016) were observed.ConclusionWe suggest that the negative effect induced by severe overt HT on the cardiovascular system can be significantly improved by restoring euthyroidism with short‐term levothyroxine therapy.Level of Evidence: 1Technical Efficacy: Stage 2J. MAGN. RESON. IMAGING 2017;46:897–904
Patient compliance following isolated mandibular fracture repair
Authors: Radabaugh J. Paul , Horn Adam Van , Chan Stephen A. , Shelton Jared M. , Gal Thomas J. 
Published: March 2017

ObjectiveCompliance with postoperative care in the maxillofacial trauma population often is considered poor. This lack of follow‐up does not seem to be a function of decreased access to care but rather its anticipated lack of utilization. The goal of this study is to identify what factors are associated with increased compliance in postoperative management of mandible fractures.Study DesignRetrospective cohort study.MethodsUsing Current Procedural Terminology codes to identify maxillofacial injuries requiring operative repair, a subset of isolated mandibular fractures was identified. Age, gender, race, insurance type, travel distance, mandible fracture location, surgical approach, and complications were used as variables in univariate regression modeling to examine factors associated with compliance to postoperative care.ResultsBetween 2010 and 2013, 344 isolated mandible fractures were identified. A total of 83.1% of patients made their first postoperative follow‐up visit. Demographic data, fracture location, distance to medical center (odds ratio [OR] = 1, P = 0.75), type of repair, use of drains (OR = 1.27, P = 0.61), or nonabsorbable suture (OR = 1.44, P = 0.32) did not appear to be associated with compliance. No association between complications and postoperative compliance was observed (OR = 2.37, P = 0.17). Trends toward improved compliance were observed when evaluating insurance type and use of temporary fixation hardware. The presence of current tobacco use was found to be negatively associated with patient compliance (OR = 0.33, P < 0.01).ConclusionPostoperative compliance after surgical repair is better than what is currently represented in the literature. It appears that postoperative compliance is dependent on patient‐related factors more so than what can be modified by the surgeon.Level of Evidence4. Laryngoscope, 127:2230–2235, 2017
Multiblock poly(Phenylene ether nitrile)s with pendant sulfoalkoxyl side chain for H2/air fuel cells at low humidity condition
Authors: Dong Tiandu , He Bin , Li Xinze , Wu Congcong , Li Nanwen , Ueda Mitsuru , Zhang Xuan , Wang Lianjun 
Published: March 2017

ABSTRACTA series of multiblock poly(phenylene ether nitrile)s with pendant sulfoalkoxyl side chains have been developed as proton exchange membranes for fuel cells. The membranes were obtained by a solution casting method and exhibited good thermal stability, flexibility, and mechanical strength. The membranes displayed well‐developed microphase separation, which largely contributed to their excellent ion conduction ability. One of the new membranes with a low ion exchange capacity of 1.57 mequiv g−1 showed higher proton conductivity than Nafion 212 over the entire RH range (30–95%). The maximum power output generated in a single cell test reached up to 0.754, 0.640, and 0.414 W cm−2 at 70 °C under 80%, 50%, and 30% RH conditions, respectively. The current density of the membrane obtained at 0.6 V (I0.6) was as high as 640 mA cm−2, which was much higher than that of Nafion 212 (375 mA cm−2 at 30% RH), suggesting its superiority for a more rapid system start‐up. Furthermore, the in situ durability test at 50% RH was performed at a constant current loading, and the membrane did not show any significant voltage reduction over the 400 h testing period. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1940–1948
Double‐stranded ladderphanes with C2‐symmetric planar chiral ferrocene linkers
Authors: Xu Jun , Zhang Ze , Liu Yi‐Hung , Guo Qingxiang , Wang Guan‐Wu , Lai Guoqiao , Luh Tien‐Yau 
Published: March 2017

ABSTRACTEight ladderphanes with C2‐symmetric planar chiral ferrocene linkers are synthesized by ring opening metathesis polymerization of bisnorbornene monomers using Grubbs‐I catalyst. The aminobenzoate in both monomers and polymers shows absorption maximum around 320 nm. Both monomers and polymers are Circular dichroism (CD) active. Little enhancements of CD profiles around 320 nm are observed for ladderphanes having chiral chloro‐ or phenyl‐substituted ferrocene linkers. However, ladderphanes with a phenyl substituent on the cyclopendienyl ring exhibits enhancement of CD curves aound 240–300 nm. The congested phenyl moieties in adjacent linkers in this polymer might be well oriented such that interactions between these aromatic substituents on different monomeric units might provoke the enhancement of the CD curves in this region. When the methyl‐substituted cyclopendienyl ligand is used for chiral ferrocene linkers, the ladderphanes exhibit two‐fold enhancement of CD spectrum around 320 nm. This enhancement is further increased when the cyclopentadienyl ligand contains an additional phenyl substituent, owing to exciton coupling between aminobenzoate moieties in adjacent monomeric units. Moreover, the intensity of the CD curves in the region of 240–300 nm is significantly increased. These results suggest that the later polymer may adopt a posible helical structure. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2999–3010
Benchmark values of Shannon entropy for spherically confined hydrogen atom
Authors: Jiao Li Guang , Zan Li Rong , Zhang Yong Zhi , Ho Yew Kam 
Published: March 2017

AbstractThe information‐theoretic measure of confined hydrogen atom has been investigated extensively in the literature. However, most of them were focused on the ground state and accurate values of information entropies, such as Shannon entropy, for confined hydrogen are still not determined. In this work, we establish the benchmark results of the Shannon entropy for confined hydrogen atom in a spherical impenetrable sphere, in both position and momentum spaces. This is done by examining the bound state energies, the normalization of wave functions, and the scaling property with respect to isoelectronic hydrogenic ions. The angular and radial parts of Shannon entropy in two conjugate spaces are provided in detail for both free and confined hydrogen atom in ground and several excited states. The entropies in position space decrease logarithmically with decreasing the size of confinement, while those in momentum space increase logarithmically. The Shannon entropy sum, however, approaches to finite values when the confinement radius closes to zero. It is also found that the Shannon entropy sum shares same trend for states with similar density distributions. Variations of entropy for nodeless bound states are significantly distinct form those owning nodes when changing the confinement radius.
Photo Chemical Hydrogen Generation from Orthorhombic CaFe2O4 Nanoparticles Synthesized by Different Methods
Authors: Dom Rekha , Kim Hyun Gyu , Borse Pramod H. 
Published: March 2017

AbstractCaFe2O4 (CFO) nanoparticles with the orthorhombic phase were synthesized using solid state reaction (SSR), polymer complex (PC), microwave sintering (μW) and self‐propagating combustion (SPC) methods. Hydrogen (H2) evolution by photocatalytic water splitting (WS), over these nanoparticles have been investigated and compared. Their crystallinity, surface area, and band energetics have been studied. It reveals that the CFO synthesized by SSR, PC, μW methods exhibit high crystallinity than that obtained in SPC. The μW synthesized CFO photocatalysts (PHC) exhibited better optical properties than those obtained using conventional SSR route, though they took <60 times less preparation time than SSR. The optical and electrochemical measurements indicate that the CFO shows suited band energetic for H2 generation by WS. In particular, the CFO PHCs obtained from μW method are most efficient &display an order high quantum yield (1.57 %) than others. Electrodes fabricated from μW sintered PHC exhibited low electrochemical charge transfer resistance (CTR) than others yielding high efficiency.
Synthesis of Annulated Thiophenes Involving Benzo‐DMTHFs/Triflic acid‐Mediated Domino Reactions
Authors: Rafiq Settu Muhammad , Mohanakrishnan Arasambattu K. 
Published: March 2017

AbstractA facile protocol for synthesis of naphth‐annulated thiophenes has been developed via benzo‐DMTHFs/triflic acid‐mediated annulation of thiophenes. Furthermore, this methodology was found to be successful with substituted benzo‐DMTHFs as well as higher homologues of benzo‐DMTHF.
Model‐based receding horizon control of wind farms for secondary frequency regulation
Authors: Shapiro Carl R. , Bauweraerts Pieter , Meyers Johan , Meneveau Charles , Gayme Dennice F. 
Published: March 2017

AbstractIn this study, we propose the use of model‐based receding horizon control to enable a wind farm to provide secondary frequency regulation for a power grid. The controller is built by first proposing a time‐varying one‐dimensional wake model, which is validated against large eddy simulations of a wind farm at startup. This wake model is then used as a plant model for a closed‐loop receding horizon controller that uses wind speed measurements at each turbine as feedback. The control method is tested in large eddy simulations with actuator disk wind turbine models representing an 84‐turbine wind farm that aims to track sample frequency regulation reference signals spanning 40 min time intervals. This type of control generally requires wind turbines to reduce their power set points or curtail wind power output (derate the power output) by the same amount as the maximum upward variation in power level required by the reference signal. However, our control approach provides good tracking performance in the test system considered with only a 4% derate for a regulation signal with an 8% maximum upward variation. This performance improvement has the potential to reduce the opportunity cost associated with lost revenue in the bulk power market that is typically associated with providing frequency regulation services. Copyright © 2017 John Wiley & Sons, Ltd.
RETRACTED ARTICLE: Structural features and seismotectonic implications of coseismic surface ruptures produced by the 2016 Mw 7.1 Kumamoto earthquake
Authors: Lin Aiming 
Published: March 2017

AbstractField investigations and analyses of satellite images and aerial photographs reveal that the 2016 Mw 7.1 (Mj 7.3) Kumamoto earthquake produced a ∼40-km surface rupture zone striking NE-SW on central Kyushu Island, Japan. Coseismic surface ruptures were characterized by shear faults, extensional cracks, and mole tracks, which mostly occurred along the pre-existing NE-SW-striking Hinagu–Futagawa fault zone in the southwest and central segments, and newly identified faults in the northeast segment. This study shows that (i) the Hinagu–Futagawa fault zone triggered the 2016 Kumamoto earthquake and controlled the spatial distribution of coseismic surface ruptures; (ii) the southwest and central segments were dominated by right-lateral strike-slip movement with a maximum in-site measured displacement of up to 2.5 m, accompanied by a minor vertical component. In contrast, the northeast segment was dominated by normal faulting with a maximum vertical offset of up to 1.75 m with a minor horizontal component that formed graben structures inside Aso caldera; (iii) coseismic rupturing initiated at the jog area between the Hinagu and Futagawa faults, then propagated northeastward into Aso caldera, where it terminated. The 2016 Mw 7.1 Kumamoto earthquake therefore offers a rare opportunity to study the relationships between coseismic rupture processes and pre-existing active faults, as well as the seismotectonics of Aso volcano.
Incorporation of Flaxseed Flour as a Dietary Source for ALA Increases Bone Density and Strength in Post‐Partum Female Rats
Authors: Ribeiro Danielle Cavalcante , Pereira Aline D'Avila , de Santana Fernanda Carvalho , Mancini‐Filho Jorge , da Silva Eduardo Moreira , da Costa Carlos Alberto Soares , Boaventura Gilson Teles 
Published: March 2017

AbstractIn women, bone mass undergoes changes during pregnancy and the postpartum period, which has a risk for subsequent development of osteoporosis. Thus, the present study aims to evaluate the effects of flaxseed flour in femur quality during post‐weaning of dam rats. After weaning, the rats were divided into control (C, n = 7) and experimental (F, n = 7) groups treated with a diet containing 25 g of flaxseed flour in the lactating period and 15 g in the maintenance period. After 51 days post‐partum, serum hormone, fatty acids composition, bone compartments, computed tomography, and biomechanical analyses were determined. Food intake, length, body mass, hormone analysis, and total bone compartments showed similar results. For biomechanical and computed tomography analysis and fatty acids composition, the F group showed higher maximum force (+12%, p < 0.05), breaking strength (+25%, p < 0.05), rigidity (+17%, p < 0.0001), and femoral head radiodensity (+15%, p < 0.05) and presented lower total polyunsaturated fatty acids (−17%, p < 0.0001) and arachidonic acid (−44%, p < 0.0001) and higher ALA (+695%, p < 0.0001) and EPA (+160%, p < 0.05). Fatty acids composition of flaxseed flour, as well as its protein profile and calcium content, were able to improve the bone quality, which may be associated with lower serum levels of arachidonic acid and higher EPA, showing an anti‐inflammatory profile and increased deposition of organic matrix during the post‐weaning period, and may result in prevention of future osteoporosis.