bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПАТОГЕНЕТИЧНІ АСПЕКТИ ДИСФУНКЦІЇ ЕНДОТЕЛІЮ У ХВОРИХ НА АРТЕРІАЛЬНУ ГІПЕРТЕНЗІЮ З ЦУКРОВИМ ДІАБЕТОМ: РОЛЬ МОНООКСИДУ НІТРОГЕНУ
Authors: Шоріков Є. І. 
Published: May 2016

<p>Cтаття присвячена дослідженню вмісту монооксиду нітрогену в пацієнтів із гіпертонічною хворобою з цукровим діабетом 2 типу залежно від наявності інсулінорезистентності, типу ендотелійзалежної вазодилатації, ремоделювання судин еластичного типу. Встановлено вірогідне зниження метаболітів оксиду азоту у хворих на гіпертонічну хворобу з цукровим діабетом 2 типу, асоційоване зі збільшенням вмісту глюкози, інсуліну та зростанням індексу інсулінорезистентності. Виявлено вірогідний зв’язок між вмістом метаболітів монооксиду нітрогену, показниками ліпідного обміну,індексом атерогенності та метаболічним індексом. У хворих із порушеною судинною функцією при ендотелійзалежній вазодилатації спостерігається вірогідно нижчий вміст метаболітів оксиду азоту. Встановлено вірогідний зв’язок між зменшенням NO<sub>2</sub> / NO<sub>3</sub>, коефіцієнтом розтяжності аорти, показниками локальної жорсткості, швидкістю пульсової хвилі, модулем еластичності Петерсона та загальним артеріальним комплайєнсом.</p>
ОСОБЛИВОСТІ ДИСПЛАСТИЧНИХ УРАЖЕНЬ ЕПІТЕЛІЮ ШИЙКИ МАТКИ У ЖІНОК РЕПРОДУКТИВНОГО ВІКУ З ЛЕЙОМІОМОЮ МАТКИ
Authors: Нарольська А. І. , Задорожна Т. Д. , Горбань Н. Є. 
Published: May 2016

<p>Дано оцінку диспластичних уражень епітелію шийки матки у жінок репродуктивного віку з лейоміомою матки. Обстежено 60 жінок репродуктивного віку з наявністю патології шийки матки (шМ) та лейоміомою матки на тлі інфікування високоонкогенними штамами вірусу папіломи людини (ВПл): перша група – 30 жінок із лейоміомою матки (лМ) та хронічними запальними захворюваннями (хЗЗ) органів малого таза (ОМТ), друга група – 30 жінок із лМ без наявності супутніх хЗЗ ОМТ. За результатами цитологічного та кольпоскопічного обстежень епітелію шийки матки (ешМ) у всіх хворих встановлено наявність виражених дистрофічних змін у клітинах плоского та залозистого епітелію, аномальні кольпоскопічні ознаки – показники яких збільшувались залежно від вираження цервікальної інтраепітеліальної неоплазії та були найбільш вираженим у пацієнток першої групи. У всіх обстежених жінок визначено глибокі зміни багатошарового плоского епітелію. Цитологічно – на тлі койлоцитарної гіперплазії виявлено диспластичні зміни багатошарового плоского ешМ (LsIL та HsIL), гістологічно та імуногістохімічно верифіковано диспластичні ураження сквамозного епітелію різного ступеня вираження (CIn I–III). Індекс клітинної проліферації (Кі-67) підвищувався паралельно зростанню ступеня ураження ешМ. Найтяжчі вищезазначені патологічні зміни були виявлені у пацієнток першої групи.</p>
ІМУНОБІОХІМІЧНІ ЗМІНИ У КРОВІ ПРИ ГОСТРОМУ ІШЕМІЧНОМУ ІНСУЛЬТІ
Authors: Михалойко О. Я. 
Published: May 2016

<p>Проведено клініко-неврологічне обстеження 120 пацієнтів із гострим ішемічним інсультом. Діагноз верифікували за даними спіральної комп’ютерної та магнітно-резонансної томографій. Контрольну групу становили 20 осіб без ознак гострого порушення мозкового кровообігу та тяжкої соматичної патології віком (59,35±1,80) року. Всім хворим на 1–2 день після виникнення інсульту методом імуноферментного аналізу було визначено концентрацію васкулоендотеліального фактора росту (ВеФр) у крові та ліпідний спектр крові – ензиматичним калориметричним методом. У результаті дослідження у всіх пацієнтів фіксували достовірне підвищення концентрації ВеФр у крові (378,5±44,6) пг/мл, p&lt;0,001, при чому вираження експресії ВеФр асоціювалось із ступенем тяжкості ішемічного інсульту. було встановлено пряму залежність збільшення концентрації ВеФр від зростання гіперліпідемії, що пояснює факт посилення ангіагенезу при атеросклеротичному ураженні судин.</p>
Neurobehavioral toxicity of carbon nanotubes in mice
Authors: Gholamine Babak , Karimi Isaac , Salimi Amir , Mazdarani Parisa , Becker Lora A 
Published: May 2016

Objectives: The aim of this study was to evaluate neurobehavioral toxicity of single-walled (SWNTs) and multiwalled carbon nanotubes (MWNTs) in mice. Methods: Male NMRI mice were randomized into 5 groups ( n = 10 each): Normal control (NC) group was injected intraperitoneally (i.p.) with phosphate-buffered saline (PBS) solution (pH 7.8; ca. 1 mL), MW80 and MW800 groups were injected with either i.p. 80 or 800 mg kg−1 MWNTs suspended in 1 mL of PBS and SW80 and SW800 groups were injected with either i.p. 80 or 800 mg kg−1 SWNTs suspended in 1 mL of PBS. After 2 weeks, five mice from each group were evaluated for brain-derived neurotrophic factor (BDNF) messenger RNA expression and protein content of brain tissues. Locomotion, anxiety, learning and memory, and depression were measured by open field test (OFT), elevated plus-maze (EPM), object recognition test (ORT), and forced swimming test (FST), respectively. Results: Ambulation time and center arena time in the OFT did not change among groups. In the EPM paradigm, SWNTs (800 mg kg−1) and MWNTs (80 and 800 mg kg−1) showed an anxiogenic effect. In ORT, MWNTs (80 mg kg−1) increased the discrimination ratio while in FST, MWNTs showed a depressant effect as compared to vehicle. The BDNF gene expression in mice treated with 80 and 800 mg kg−1 SWNTs or 80 mg kg−1 MWNTs decreased as compared to NC mice although BDNF gene expression increased in mice that were treated with 800 mg kg−1 MWNTs. The whole brain BDNF protein content did not change among groups. Conclusion: Our study showed that i.p. exposure to carbon nanotubes (CNTs) may result in behavioral toxicity linked with expression of depression or anxiety that depends on the type of CNTs. In addition, exposure to CNTs changed BDNF gene expression.
Association Between Perinatal Hypoxic-Ischemic Conditions and Attention-Deficit/Hyperactivity Disorder
Authors: Zhu Tingting , Gan Jing , Huang Jichong , Li Yafei , Qu Yi , Mu Dezhi 
Published: May 2016

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder worldwide, but its etiology is still not fully understood. Previous studies have reported that perinatal hypoxic-ischemic conditions may be a potential cause of ADHD. Methods: An online search of potential English studies published before September 2015 was conducted using the PsycINFO, EMBASE, Web of Science, and PubMed databases. The combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models. Results: Ten studies were included, with 45 821 cases and 9 207 363 controls. The metaresults found that the following were associated with ADHD: preeclampsia (OR 1.31; 95% CI 1.26-1.37), an Apgar score <7 at 5 minutes (OR 1.31; 95% CI 1.12-1.54), breech/transverse presentations (OR 1.14; 95% CI 1.06-1.23), and a prolapsed/nuchal cord (OR 1.10; 95% CI 1.06-1.15). Conclusion: Our results support that perinatal hypoxia-ischemia may contribute to ADHD. However, more clinical studies are warranted.
Correlation between the Modified Systemic Lupus Erythematosus Disease Activity Index 2000 and the European Consensus Lupus Activity Measurement in juvenile systemic lupus erythematosus
Authors: Sato J O , Corrente J E , Saad-Magalhães C 
Published: May 2016

Objective The objective of this study was to assess Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and European Consensus Lupus Activity Measurement (ECLAM) disease activity correlation in addition to their respective correlation to Pediatric Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (Ped-SDI), in juvenile systemic lupus erythematosus (JSLE). Methods The activity indices were scored retrospectively and summarized by adjusted means during follow-up. The Ped-SDI was scored during the last visit for those with more than six months follow-up. Pearson correlation between the Modified SLEDAI-2K and ECLAM, as well as Spearman correlations between the Modified SLEDAI-2K, ECLAM, and Ped-SDI were calculated. The receiver operating characteristic (ROC) curve was calculated for both activity indices discriminating damage measured by Ped-SDI. Results Thirty-seven patients with mean age at diagnosis 11 ± 2.9 years and mean follow-up time 3.2 ± 2.4 years were studied. The Modified SLEDAI-2K and ECLAM adjusted means were highly correlated ( r = 0.78, p < 0.001). Similarly, Spearman correlation between the activity indices was also high ( rs > 0.7, p < 0.001), but Modified SLEDAI-2K and ECLAM correlation with Ped-SDI was only moderate. ROC analysis discriminant performance for both activity indices resulted in area under curve (AUC) of 0.74 and 0.73 for Modified SLEDAI-2K and ECLAM, respectively. Conclusion The high correlation found between the Modified SLEDAI-2K and ECLAM adjusted means indicated that both tools can be equally useful for longitudinal estimates of JSLE activity.
Migration and psychosis in acute inpatient psychiatry
Authors: Lim Grace YX , Wong Michael TH 
Published: May 2016

Objective: We investigated the role of biological and psychosocial risk factors in the development of psychotic disorders with regards to immigrant status. Our hypothesis was that biological risk factors are more predictive of psychosis in non-immigrants, whereas psychosocial risk factors play a bigger role in immigrants. Method: A retrospective audit of admissions between December 2013 and June 2014 in an Australian adult inpatient unit was conducted, focussing on patients with psychotic disorders. We analysed the association between immigrant status, and biological and psychosocial variables. Results: For biological risk factors, non-immigrants had significantly more family history of psychotic disorders ( p = 0.021), illicit drug use ( p = < 0.001) and alcohol use ( p = < 0.001). For psychosocial risk factors, immigrants were more likely to have experienced a traumatic event ( p = 0.022). With regards to age of index presentation, age at onset of psychotic disorder, proportion of males and dysfunctional family background, there was no significant difference. Conclusion: Retrospective data in this report suggests that the development of psychotic disorders in immigrants and non-immigrants may be different.
Music Game Enjoyment and Natural Mapping Beyond Intuitiveness
Authors: Wechselberger Ulrich 
Published: May 2016

Introduction and statement of problem. Despite the success of music games with instrument-shaped controllers, little is known about what makes these kind of controllers entertaining. The aim of this article is to shed light on the enjoyment mechanisms of such music games and their particular controllers. Review of the literature. The literature’s theoretical foundation lies in the concept of natural mapping, i.e. the similarity of actions performed in the real world and their representation within the videogame. A review of the literature finds that most approaches are too simplistic, as they limit game enjoyment with natural mapping to higher intuitiveness. In contrast, challenge can also foster game enjoyment. Methodology. Two parallelized sample groups (N=20) played three levels of a music game with increasing difficulty with either a Guitar Hero controller or with a real guitar. Perceived difficulty and game enjoyment were collected via questionnaires. Analysis. A 2x3 mixed-design ANOVA was conducted for significance testing. It revealed a significant increase in enjoyment and perceived difficulty both for advanced game levels and the real guitar. A posteriori multiple regression showed that the increase in enjoyment with the real guitar could not be attributed to the higher challenge it produced alone. Conclusions and recommendations for further research. The results suggest that intuitiveness is not the single factor for music game enjoyment with natural controllers. Further research might investigate the role of simulation and identification with attractive roles, as both could act as sources for game enjoyment and natural mapping might facilitate these factors. Applications for learning and teaching should consider debriefing as a method to facilitate transfer of the game experience into the real world.
Is no evidence of disease activity an achievable goal in MS patients on intramuscular interferon beta-1a treatment over long-term follow-up?
Authors: Uher Tomas , Havrdova Eva , Sobisek Lukas , Krasensky Jan , Vaneckova Manuela , Seidl Zdenek , Tyblova Michaela , Ramasamy Deepa , Zivadinov Robert , Horakova Dana 
Published: May 2016

Background: No evidence of disease activity (NEDA) has been proposed as a new treatment goal in multiple sclerosis (MS). NEDA-3 status is defined as the absence of magnetic resonance imaging (MRI; new/enlarging/enhancing lesions and increased whole brain volume loss in NEDA-4) and clinical disease activity. Objectives: To investigate the persistence of NEDA status over long-term follow-up in MS patients treated with weekly intramuscular interferon beta-1a. Methods: We included 192 patients after the first demyelinating event suggestive of MS, that is, clinically isolated syndrome (CIS) and 162 relapsing-remitting MS (RRMS) patients. Results: NEDA-3 status was observed in 40.1% of CIS and 20.4% of RRMS patients after 1 year. After 4 years, 10.1% of CIS patients had NEDA-3 status. After 10 years, none of the RRMS patients had NEDA-3 status. Only 4.6% of CIS and 1.0% of RRMS patients maintained NEDA-4 status after 4 years. Loss of NEDA-3 status after the first year was associated with a higher risk of disability progression (hazard ratio (HR) = 2.3–4.0; p = 0.005–0.03) over 6 years. Conclusions: Despite intramuscular interferon beta-1a treatment, loss of NEDA status occurred in the vast majority of individuals. Loss of NEDA status during the first year was associated with disability progression over long-term follow-up; however, specificity for individual patient was low.
Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia
Authors: Irving Julie A. E. , Enshaei Amir , Parker Catriona A. , Sutton Rosemary , Kuiper Roland P. , Erhorn Amy , Minto Lynne , Venn Nicola C. , Law Tamara , Yu Jiangyan , Schwab Claire , Davies Rosanna , Matheson Elizabeth , Davies Alysia , Sonneveld Edwin , den Boer Monique L. , Love Sharon B. , Harrison Christine J. , Hoogerbrugge Peter M. , Revesz Tamas , Saha Vaskar , Moorman Anthony V. 
Published: May 2016

Key Points
Chromosomal abnormalities predict outcome after relapse in BCP-ALL, and high-risk cytogenetics takes precedence over clinical risk factors. Patients with mutations or deletions targeting TP53, NR3C1, BTG1, and NRAS were associated with clinical high risk and an inferior outcome.
Digital health for the End TB Strategy: developing priority products and making them work
Authors: Falzon Dennis , Timimi Hazim , Kurosinski Pascal , Migliori Giovanni Battista , Van Gemert Wayne , Denkinger Claudia , Isaacs Chris , Story Alistair , Garfein Richard S. , do Valle Bastos Luis Gustavo , Yassin Mohammed A. , Rusovich Valiantsin , Skrahina Alena , Van Hoi Le , Broger Tobias , Abubakar Ibrahim , Hayward Andrew , Thomas Bruce V. , Temesgen Zelalem , Quraishi Subhi , von Delft Dalene , Jaramillo Ernesto , Weyer Karin , Raviglione Mario C. 
Published: May 2016

In 2014, the World Health Organization (WHO) developed the End TB Strategy in response to a World Health Assembly Resolution requesting Member States to end the worldwide epidemic of tuberculosis (TB) by 2035. For the strategy's objectives to be realised, the next 20 years will need novel solutions to address the challenges posed by TB to health professionals, and to affected people and communities. Information and communication technology presents opportunities for innovative approaches to support TB efforts in patient care, surveillance, programme management and electronic learning. The effective application of digital health products at a large scale and their continued development need the engagement of TB patients and their caregivers, innovators, funders, policy-makers, advocacy groups, and affected communities.In April 2015, WHO established its Global Task Force on Digital Health for TB to advocate and support the development of digital health innovations in global efforts to improve TB care and prevention. We outline the group's approach to stewarding this process in alignment with the three pillars of the End TB Strategy. The supplementary material of this article includes target product profiles, as developed by early 2016, defining nine priority digital health concepts and products that are strategically positioned to enhance TB action at the country level.
Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography
Authors: Subramanian Deepak R. , Gupta Sumit , Burggraf Dorothe , vom Silberberg Suzan J. , Heimbeck Irene , Heiss-Neumann Marion S. , Haeussinger Karl , Newby Chris , Hargadon Beverley , Raj Vimal , Singh Dave , Kolsum Umme , Hofer Thomas P. , Al-shair Khaled , Luetzen Niklas , Prasse Antje , Müller-Quernheim Joachim , Benea Giorgio , Leprotti Stefano , Boschetto Piera , Gorecka Dorota , Nowinski Adam , Oniszh Karina , Castell Wolfgang zu , Hagen Michael , Barta Imre , Döme Balázs , Strausz Janos , Greulich Timm , Vogelmeier Claus , Koczulla Andreas R. , Gut Ivo , Hohlfeld Jens , Welte Tobias , Lavae-Mokhtari Mahyar , Ziegler-Heitbrock Loems , Brightling Christopher , Parr David G. 
Published: May 2016

EvA (EmphysemaversusAirway disease) is a multicentre project to study mechanisms and identify biomarkers of emphysema and airway disease in chronic obstructive pulmonary disease (COPD). The objective of this study was to delineate objectively imaging-based emphysema-dominant and airway disease-dominant phenotypes using quantitative computed tomography (QCT) indices, standardised with a novel phantom-based approach.441 subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1–3) were assessed in terms of clinical and physiological measurements, laboratory testing and standardised QCT indices of emphysema and airway wall geometry.QCT indices were influenced by scanner non-conformity, but standardisation significantly reduced variability (p<0.001) and led to more robust phenotypes. Four imaging-derived phenotypes were identified, reflecting “emphysema-dominant”, “airway disease-dominant”, “mixed” disease and “mild” disease. The emphysema-dominant group had significantly higher lung volumes, lower gas transfer coefficient, lower oxygen (PO2) and carbon dioxide (PCO2) tensions, higher haemoglobin and higher blood leukocyte numbers than the airway disease-dominant group.The utility of QCT for phenotyping in the setting of an international multicentre study is improved by standardisation. QCT indices of emphysema and airway disease can delineate within a population of patients with COPD, phenotypic groups that have typical clinical features known to be associated with emphysema-dominant and airway-dominant disease.
Sagittal alignment of the spine-pelvis-lower extremity axis in patients with severe knee osteoarthritis
Authors: Wang W. J. , Liu F. , Zhu Y.W. , Sun M.H. , Qiu Y. , Weng W. J. 
Published: May 2016

Objectives Normal sagittal spine-pelvis-lower extremity alignment is crucial in humans for maintaining an ergonomic upright standing posture, and pathogenesis in any segment leads to poor balance. The present study aimed to investigate how this sagittal alignment can be affected by severe knee osteoarthritis (KOA), and whether associated changes corresponded with symptoms of lower back pain (LBP) in this patient population. Methods Lateral radiograph films in an upright standing position were obtained from 59 patients with severe KOA and 58 asymptomatic controls free from KOA. Sagittal alignment of the spine, pelvis, hip and proximal femur was quantified by measuring several radiographic parameters. Global balance was accessed according to the relative position of the C7 plumb line to the sacrum and femoral heads. The presence of chronic LBP was documented. Comparisons between the two groups were carried by independent samples t-tests or chi-squared test. Results Patients with severe KOA showed significant backward femoral inclination (FI), hip flexion, forward spinal inclination, and higher prevalence of global imbalance (27.1% versus 3.4%, p < 0.001) compared with controls. In addition, patients with FI of 10° (n = 23) showed reduced lumbar lordosis and significant forward spinal inclination compared with controls, whereas those with FI > 10° (n = 36) presented with significant pelvic anteversion and hip flexion. A total of 39 patients with KOA (66.1%) suffered from LBP. There was no significant difference in sagittal alignment between KOA patients with and without LBP. Conclusions The sagittal alignment of spine-pelvis-lower extremity axis was significantly influenced by severe KOA. The lumbar spine served as the primary source of compensation, while hip flexion and pelvic anteversion increased for further compensation. Changes in sagittal alignment may not be involved in the pathogenesis of LBP in this patient population. Cite this article: W. J. Wang, F. Liu, Y.W. Zhu, M.H. Sun, Y. Qiu, W. J. Weng. Sagittal alignment of the spine-pelvis-lower extremity axis in patients with severe knee osteoarthritis: A radiographic study. Bone Joint Res 2016;5:198–205. DOI:10.1302/2046-3758.55.2000538.
Optimization design of a flexible absorption device for solar energy application
Authors: Jia Hao , Zhu Jingjing , Li Zhaoling , Guo Jiansheng 
Published: May 2016

Abstract
With the fast development of solar energy harvesting technology, various portable harvesters with excellent energy capture properties are highly desired, especially those devices used for facades and roofs of buildings. This study proposed a new energy absorption model by integrating wave-guiding polymer materials and fluorescent substance coated textiles, which aimed to address the issues of current energy shortage and excessive pollutant emissions in the ambient environment. Besides, this textile-based production was multifunctional in that it possessed the compelling features of solar radiation collection, thermal insulation and surface decoration. Compared with the conventional solar energy harvester, the as-fabricated device exhibited the merits of light weight, better mechanical flexibility and wider extended applicability. This study has achieved some progress in the area of solar energy harvesting and could have a possible informative effect on the future related research.
Wer hat Angst vor »Trivialliteratur«? Eugenie Marlitts ruhige Revolution
Authors: Liebs Elke 
Published: May 2016

Abstract
Following Susanne Clark’s idea of restoring the sentimental to the history of literary modernity, my article investigates the work of the German writer Eugenie Marlitt as part of the modern tradition. Under the cover of the conventional discourse of so-called »trivial literature« (Trivialliteratur) Marlitt turns her female characters into representations of a new feminine ethic and aesthetic. Thus she combines the revolutionary and the reactionary in order to overcome gendered role models, bridging the gap between the »popular« and the »elite«, between emotional culture and rational self-confidence.
Von Hexen und weißen Elfen. Zum literarischen Werk von George Egerton
Authors: Rosenberg Ingrid von 
Published: May 2016

Abstract
Among the so-called »new woman writers« of the 1890s Australianborn George Egerton (Mary Chavelita Dunne) was in her time certainly the most notorious, because the most daring. In her short stories, especially in her two first collections Keynotes (1893) and Discords (1894), which became sensational successes, she explored what she called the terra incognita of the female psyche, i.e. women’s deepest wishes hidden below the conventions of patriarchal Victorian society. With amazing independence of mind Egerton rethought gender roles in sex, marriage, parenthood and work and was almost inevitably led to use stream-of-consciousness technique before Joyce and Woolf. The article evaluates Egerton’s contribution to modernist topics and narrative techniques and pleads for the rediscovery of her work.