bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prussian Blue Degradation during Hydrogen Peroxide Reduction: A Scanning Electrochemical Microscopy Study on the Role of the Hydroxide Ion and Hydroxyl Radical
Authors: Noël Jean‐Marc , Médard Jérôme , Combellas Catherine , Kanoufi Frédéric 
Published: May 2016

AbstractThe degradation of Prussian blue (PB) during H2O2 reduction is investigated by scanning electrochemical microscopy (SECM). Coupling SECM with optical microscopy allows quantitative assessment in situ of the effect of HO− on the dissolution of PB in lithographic experiments. The local production of HO− in the vicinity of PB is an easy way to pattern a PB layer; Such PB dissolution during H2O2 reduction leads to the release of soluble ferrocyanide and Fe2+. In the presence of H2O2, the latter initiate the Fenton reaction and the generation of highly reactive hydroxyl radicals HO.. This is revealed by the degradation of an organic layer immobilized on an ultramicroelectrode held in the vicinity of a PB layer during H2O2 reduction. The formation of such reactive species is of great importance to further understand the possible origin of the activity loss of sensors, batteries, and photovoltaic cells when composite materials based on PB or on its derivatives are used as catalysts for H2O2 or O2 reduction.
Unambiguous Identification of β‐Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling
Authors: Zhou Bo , Yu Xingxin , Zhuang Chunlin , Villalta Peter , Lin Yong , Lu Junxuan , Xing Chengguo 
Published: May 2016

AbstractChalcone is a simple and potentially privileged structure in medicinal chemistry with a diverse repertoire of biological activities, among which cytotoxicity is of particular interest. The sharp structure–activity relationship (SAR) for chalcone's cytotoxicity suggests structure‐specific target interactions. Despite the numerous putative targets proposed, evidence for direct target interactions in cells is unavailable. In this study, guided by the sharp cytotoxic SAR, we developed a cytotoxic chalcone‐based photoaffinity labeling (PAL) probe, (E)‐3‐(3‐azidophenyl)‐1‐[3,5‐dimethoxy‐4‐(prop‐2‐yn‐1‐yloxy)phenyl]‐2‐methylprop‐2‐en‐1‐one (C95; IC50: 0.38±0.01 μm), along with two structurally similar non‐cytotoxic probes. These probes were used to search for the direct cellular target responsible for chalcone's cytotoxicity through intact cell‐based PAL experiments, in which β‐tubulin was identified to specifically interact with the cytotoxic probe (i.e., C95) but not the non‐cytotoxic probes. A set of phenotypical and biochemical assays further reinforced β‐tubulin as the cytotoxic target of chalcones. Peptide mass quantitation by mass spectrometric analysis revealed one peptide potentially labeled by C95, providing information on chalcone's binding site on β‐tubulin.
A phase 1 study of buparlisib and bevacizumab in patients with metastatic renal cell carcinoma progressing on vascular endothelial growth factor‐targeted therapies
Authors: McKay Rana R. , De Velasco Guillermo , Werner Lillian , Bellmunt Joaquim , Harshman Lauren , Sweeney Christopher , Rosenberg Jonathan E. , Hirsch Michelle , Signoretti Sabina , Van Allen Eliezer M. , Walsh Meghara , Vaishampayan Ulka , McDermott David F. , Choueiri Toni K. 
Published: May 2016

BACKGROUNDThe phosphatidylinositol‐3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is dysregulated in patients with metastatic renal cell carcinoma (mRCC). Buparlisib is a pan‐PI3K inhibitor with activity in advanced solid tumors. The primary objective of the current study was to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities of buparlisib and bevacizumab in patients with mRCC. Secondary objectives included efficacy, biomarker discovery, and additional toxicity.METHODSThis was a standard 3 + 3 dose escalation study of buparlisib (at a dose of 60‐100 mg/day) and bevacizumab (at a dose of 10 mg/kg every 2 weeks). After the MTD was defined, 15 patients were accrued to the expansion cohort.RESULTSThirty‐two patients were accrued (3 were treated at 60 mg/day, 21 were treated at 80 mg/day, 6 were treated at 100 mg/day, and 2 patients never received therapy). The majority of patients had clear cell histology (87%) and 50% had received ≥2 prior lines of therapy. The MTD of buparlisib was 80 mg/day and that of bevacizumab was 10 mg/kg every 2 weeks. A total of 28 patients discontinued therapy: 17 because of disease progression, 7 because of toxicity, and 4 for other reasons. Dose‐limiting toxicities included rash/pruritis, elevated lipase/amylase, anorexia, and psychiatric disorders (suicidal ideation, depression, and cognitive disturbances). Of the 30 patients who received at least 1 dose, 13% achieved a partial response (95% confidence interval, 4%‐31%). Two patients harboring activating PI3KA mutations achieved 42% and 16% maximal tumor shrinkage, respectively.CONCLUSIONSBuparlisib at a dose of 80 mg/day with bevacizumab was found to be a tolerable regimen with preliminary activity in vascular endothelial growth factor‐refractory mRCC. The benefit of this combination may be of interest for future mRCC trials, possibly in a selected patient population. Cancer 2016;122:2389–2398. © 2016 American Cancer Society.
Colorectal cancer screening: Estimated future colonoscopy need and current volume and capacity
Authors: Joseph Djenaba A. , Meester Reinier G. S. , Zauber Ann G. , Manninen Diane L. , Winges Linda , Dong Fred B. , Peaker Brandy , van Ballegooijen Marjolein 
Published: May 2016

BACKGROUNDIn 2014, a national campaign was launched to increase colorectal cancer (CRC) screening rates in the United States to 80% by 2018; it is unknown whether there is sufficient colonoscopy capacity to reach this goal. This study estimated the number of colonoscopies needed to screen 80% of the eligible population with fecal immunochemical testing (FIT) or colonoscopy and determined whether there was sufficient colonoscopy capacity to meet the need.METHODSThe Microsimulation Screening Analysis–Colon model was used to simulate CRC screening test use in the United States (2014‐2040); the implementation of a national screening program in 2014 with FIT or colonoscopy with 80% participation was assumed. The 2012 Survey of Endoscopic Capacity (SECAP) estimated the number of colonoscopies that were performed and the number that could be performed.RESULTSIf a national screening program started in 2014, by 2024, approximately 47 million FIT procedures and 5.1 million colonoscopies would be needed annually to screen the eligible population with a program using FIT as the primary screening test; approximately 11 to 13 million colonoscopies would be needed annually to screen the eligible population with a colonoscopy‐only screening program. According to the SECAP survey, an estimated 15 million colonoscopies were performed in 2012, and an additional 10.5 million colonoscopies could be performed.CONCLUSIONSThe estimated colonoscopy capacity is sufficient to screen 80% of the eligible US population with FIT, colonoscopy, or a mix of tests. Future analyses should take into account the geographic distribution of colonoscopy capacity. Cancer 2016;122:2479–86. © 2016 American Cancer Society.
Naps promote flexible memory retrieval in 12‐month‐old infants
Authors: Konrad Carolin , Seehagen Sabine , Schneider Silvia , Herbert Jane S. 
Published: May 2016

AbstractFlexibility in applying existing knowledge to similar cues is a corner stone of memory development in infants. Here, we examine the effect of sleep on the flexibility of memory retrieval using a deferred imitation paradigm. Forty‐eight 12‐month‐old infants were randomly assigned to either a nap or a no‐nap demonstration condition (scheduled around their natural daytime sleep schedule) or to a baseline control condition. In the demonstration conditions, infants watched an experimenter perform three target actions on a hand puppet. Immediately afterwards, infants were allowed to practice the target actions three times. In a test session 4‐hr later, infants were given the opportunity to reproduce the actions with a novel hand puppet differing in color from the puppet used during the demonstration session. Only infants in the nap‐condition performed significantly more target actions than infants in the baseline control condition. Furthermore, they were faster to carry out the first target action than infants in the no‐nap condition. We conclude that sleep had a facilitative effect on infants’ flexibility of memory retrieval.
Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge‐eating disorder in a nationally representative epidemiological sample
Authors: Nobles Carrie J. , Thomas Jennifer J. , Valentine Sarah E. , Gerber Monica W. , Vaewsorn Adin S. , Marques Luana 
Published: May 2016

ABSTRACTObjectiveBulimia nervosa (BN) and binge‐eating disorder (BED) are associated with significant health impairment. Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) comprise both psychological (disturbances in mood and affect) and physiological (bloating and changes in appetite) symptoms that may trigger binge‐eating and/or purging.MethodFemale participants were drawn from the Collaborative Psychiatric Epidemiological Surveys, conducted from 2001 to 2003. Weighted multivariable logistic regression modeled the association between lifetime PMS and PMDD and lifetime odds of BN or BED.ResultsAmong 8,694 participants, 133 (1.0%) had BN and 185 (1.8%) BED. Additionally, 366 (4.2%) had PMDD and 3,489 (42.4%) had PMS. Prevalence of PMDD and PMS were 17.4 and 55.4% among those with BN, 10.7 and 48.9% among those with BED and 3.4 and 59.1% among those with subthreshold BED. After adjustment for age, race/ethnicity, income, education, body mass index, age at menarche, birth control use, and comorbid mental health conditions, PMDD was associated with seven times the odds of BN (OR 7.2, 95% CI 2.3, 22.4) and PMS with two times the odds of BN (OR 2.5, 95% CI 1.1, 5.7). Neither PMDD nor PMS were significantly associated with BED.DiscussionWomen with PMS and PMDD have a higher odds of BN, independent of comorbid mental health conditions. PMS and PMDD may be important comorbidities to BN to consider in clinical settings, and future research should investigate whether PMS and PMDD affect the onset and duration of bulimic symptoms as well as the potential for shared risk factors across disorders. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:641–650)
Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells
Authors: Uzureau Sophie , Coquerelle Caroline , Vermeiren Corentin , Uzureau Pierrick , Van Acker Annette , Pilotte Luc , Monteyne Daniel , Acolty Valérie , Vanhollebeke Benoit , Van den Eynde Benoît , Pérez‐Morga David , Moser Muriel , Pays Etienne 
Published: May 2016

Apolipoproteins L (ApoLs) are Bcl‐2‐like proteins expressed under inflammatory conditions in myeloid and endothelial cells. We found that Toll‐like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8α+ dendritic cells (DCs). This induction requires the TLR3/TRIF (where TRIF is TIR domain containing adapter‐inducing interferon β) signaling pathway and is dependent on IFN‐β in all ApoLs subfamilies except for ApoL7c. Poly(I:C) treatment of DCs is also associated with induction of both cell death and autophagy. ApoLs expression is related to promotion of DC death by poly(I:C), as ApoLs7/11 knockdown increases DC survival and ApoLs7 are associated with the anti‐apoptotic protein Bcl‐xL (where Bcl‐xL is B‐cell lymphoma extra large). Similarly, in human monocyte‐derived DCs poly(I:C) induces both cell death and the expression of ApoLs, principally ApoL3. Finally, the BH3‐like peptide of ApoLs appears to be involved in the DC death‐promoting activity. We would like to propose that ApoLs are involved in cell death linked to activation of DCs by viral stimuli.
Flux and its seasonal variation of suspended particulate matter in the Bohai Sea, Yellow Sea and East China Sea
Authors: Qiao Lulu , Huang Lingling , Wang Zhen , Yao Zhigang , Liu Shidong 
Published: May 2016

AbstractTransport and flux of suspended particulate matter (SPMs) are important but hotly debated topics in the Bohai Sea (BS), Yellow Sea (YS) and East China Sea (ECS). In this study, we calculated the sediment flux and its seasonal variation combining observed suspended sediment concentration (SSC) with numerically simulated currents. Field observations were conducted in the BS, YS and ECS at 43 stations in summer and 46 stations in winter along five transects. HYCOM/NCODA reanalysis data were used to calculate climatologically monthly averaged currents in January and July from 1998 to 2007. The results indicated that a high concentration of SPM moved out of the BS and moved southward into the YS and ECS in winter, with a net sediment flux of 0.12 t/s at the Bohai Strait and 4.37 t/s south of the Yangtze River. In summer, SSC increased from the surface to the bottom layer due to stratification. A southerly wind and stronger warm currents in summer transported SPM from the ECS to the YS and the BS, with a net northward sediment flux of 4.79 t/s at the boundary of the ECS and the YS, and a net sediment flux of 0.08 t/s input into the BS. This study can help to distinguish the contribution of the Yellow River‐ and Yangtze River‐derived sediments to the mud‐areas' generation on the continental shelves area of the Yellow Sea and East China Sea. Copyright © 2016 John Wiley & Sons, Ltd.
Structural grey matter changes in the substantia innominata in Alzheimer's disease and dementia with Lewy bodies: a DARTEL‐VBM study
Authors: Colloby Sean J. , Elder Greg J. , Rabee Riham , O'Brien John T. , Taylor John‐Paul 
Published: May 2016

ObjectivesSeveral cholinergic nuclei, and in particular the nucleus basalis of Meynert, are localised to the substantia innominata in the basal forebrain. These nuclei provide major cholinergic innervation to the cerebral cortex and hippocampus, and have an essential role in cognitive function. The aim of this study was to investigate volumetric grey matter (GM) changes in the substantia innominata from structural T1 images in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and healthy older participants using voxel‐based morphometry.MethodsParticipants (41 DLB, 47 AD and 39 controls) underwent 3 T T1 magnetic resonance imaging and cognitive assessments. Voxel‐based morphometry analysis used SPM8 with a substantia innominata brain mask to define the subspace for voxel GM analyses. Group differences, and selected behavioural and clinical correlates, were assessed.ResultsCompared with that in controls, bilateral GM loss in the substantia innominata was apparent in both AD and DLB. Relative to controls, significant bilateral GM loss in the substantia innominata was observed in DLB and AD. In DLB, significant associations were also observed between substantia innominata GM volume loss, and the levels of cognitive impairment and severity of cognitive fluctuations.ConclusionsRelative to that controls, atrophy of the substantia innominata was apparent in DLB and AD, and is associated with specific clinical manifestations in DLB. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.
Selection of asset investment models by hospitals: examination of influencing factors, using Switzerland as an example
Authors: Eicher Bernhard 
Published: May 2016

SummaryHospitals are responsible for a remarkable part of the annual increase in healthcare expenditure. This article examines one of the major cost drivers, the expenditure for investment in hospital assets. The study, conducted in Switzerland, identifies factors that influence hospitals' investment decisions.A suggestion on how to categorize asset investment models is presented based on the life cycle of an asset, and its influencing factors defined based on transaction cost economics. The influence of five factors (human asset specificity, physical asset specificity, uncertainty, bargaining power, and privacy of ownership) on the selection of an asset investment model is examined using a two‐step fuzzy‐set Qualitative Comparative Analysis.The research shows that outsourcing‐oriented asset investment models are particularly favored in the presence of two combinations of influencing factors: First, if technological uncertainty is high and both human asset specificity and bargaining power of a hospital are low. Second, if assets are very specific, technological uncertainty is high and there is a private hospital with low bargaining power, outsourcing‐oriented asset investment models are favored too. Using Qualitative Comparative Analysis, it can be demonstrated that investment decisions of hospitals do not depend on isolated influencing factors but on a combination of factors. Copyright © 2016 John Wiley & Sons, Ltd.
Precision Oncology Medicine: The Clinical Relevance of Patient‐Specific Biomarkers Used to Optimize Cancer Treatment
Authors: Schmidt Keith T. , Chau Cindy H. , Price Douglas K. , Figg William D. 
Published: May 2016

AbstractPrecision medicine in oncology is the result of an increasing awareness of patient‐specific clinical features coupled with the development of genomic‐based diagnostics and targeted therapeutics. Companion diagnostics designed for specific drug‐target pairs were the first to widely utilize clinically applicable tumor biomarkers (eg, HER2, EGFR), directing treatment for patients whose tumors exhibit a mutation susceptible to an FDA‐approved targeted therapy (eg, trastuzumab, erlotinib). Clinically relevant germline mutations in drug‐metabolizing enzymes and transporters (eg, TPMT, DPYD) have been shown to impact drug response, providing a rationale for individualized dosing to optimize treatment. The use of multigene expression‐based assays to analyze an array of prognostic biomarkers has been shown to help direct treatment decisions, especially in breast cancer (eg, Oncotype DX). More recently, the use of next‐generation sequencing to detect many potential “actionable” cancer molecular alterations is further shifting the 1 gene–1 drug paradigm toward a more comprehensive, multigene approach. Currently, many clinical trials (eg, NCI‐MATCH, NCI‐MPACT) are assessing novel diagnostic tools with a combination of different targeted therapeutics while also examining tumor biomarkers that were previously unexplored in a variety of cancer histologies. Results from ongoing trials such as the NCI‐MATCH will help determine the clinical utility and future development of the precision‐medicine approach.
Adverse Drug Reactions in Patients Receiving Systemic Antifungal Therapy at a High‐Complexity Hospital
Authors: de Souza Maria Clara Padovani , Santos Andrezza Gouvêa dos , Reis Adriano Max Moreira 
Published: May 2016

AbstractThe aim of the present study was to determine the frequency of adverse drug reactions (ADRs) associated with the use of systemic antifungal drugs in patients hospitalized at a high‐complexity hospital. In addition, factors associated with ADRs were investigated. This cross‐sectional retrospective study involved the investigation of 183 medical records of patients receiving systemic antifungal therapy. Antifungal drugs were classified using the fourth level of the Anatomical Therapeutic Chemical System. ADR causality was classified using the Naranjo algorithm. Drug interactions were assessed using DRUG‐REAX software. Data were analyzed with descriptive statistics and univariate and multivariate logistic regression. A total of 53 patients (29.0%) had at least 1 ADR involving antifungals. Ninety‐six ADRs were detected. The main ADRs observed were an infusion reaction in 24 patients (25.0%), hypokalemia in 22 (22.9%), nephrotoxicity in 18 (18.7%), and hepatotoxicity in 15 (15.6%). Amphotericin B and voriconazole were associated with ADRs of major clinical impact. Eleven of the ADRs (11.4%) were related to drug interactions. The following 3 factors were contributors to the multivariate model for the occurrence of ADRs caused by antifungal drug use: neoplasm diagnosis (odds ratio [OR], 3.9; 1.9–7.9), length of hospital stay (OR, 2.2; 1.1–4.5), and the use of ≥13 drugs (OR, 3.4; 1.6–7.2). Our study revealed positive associations between the occurrence of ADRs and diagnosis of a neoplasm, the length of stay, and the use of multiple drugs concomitant with antifungals. These risk factors should be considered in antifungal stewardship, among other actions, to promote the rational use of antifungal agents.
Jellyfish decomposition at the seafloor rapidly alters biogeochemical cycling and carbon flow through benthic food‐webs
Authors: Sweetman Andrew K. , Chelsky Ariella , Pitt Kylie A. , Andrade Hector , van Oevelen Dick , Renaud Paul E. 
Published: May 2016

AbstractJellyfish blooms have increased in magnitude in several locations around the world, including in fjords. While the factors that promote jellyfish blooms and the impacts of live blooms on marine ecosystems are often investigated, the post‐bloom effects from the sinking and accumulation of dead jellyfish at the seafloor remain poorly known. Here, we quantified the effect of jellyfish deposition on short‐term benthic carbon cycling dynamics in benthic cores taken from a cold and deep fjord environment. Respiration was measured and 13C‐labeled algae were used as a tracer to quantify how C‐flow through the benthic food web was affected over 5 d in the presence and absence of jellyfish carcasses. Benthic respiration rates increased rapidly (within 2 h) in the jellyfish‐amended cores, and were significantly higher than cores that were supplied with only labeled phytodetritus between 17 h and 117 h. In the cores that were supplied with only labeled phytodetritus, macrofauna dominated algal‐C uptake over the 5 d study. The addition of jellyfish caused a rapid and significant shift in C‐uptake dynamics: macrofaunal C‐uptake decreased while bacterial C‐uptake increased relative to the cores supplied with only phytodetritus. Our results suggest that the addition of jellyfish detritus to the seafloor can rapidly alter benthic biogeochemical cycling, and substantially modify C‐flow through benthic communities. If our results are representative for other areas, they suggest that jellyfish blooms may have cascading effects for benthic ecosystem functions and services when blooms senesce, such as enhanced bacterial metabolism and reduced energy transfer to upper trophic levels.
Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists
Authors: Maslov Leonid N , Khaliulin Igor , Oeltgen Peter R. , Naryzhnaya Natalia V. , Pei Jian‐Ming , Brown Stephen A. , Lishmanov Yury B. , Downey James M. 
Published: May 2016

AbstractIt has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct‐reducing effect with prophylactic administration and prevent reperfusion‐induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia‐induced arrhythmias.