bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TACTIC: development and validation of the Tool for Assessing Chest Tube Insertion Competency
Authors: Shefrin Allan Evan , Khazei Afshin , Hung Geoffrey Robert , Odendal Lisa Teres , Cheng Adam 
Published: July 2016

AbstractObjectives: Pediatric emergency medicine (PEM) physicians receive little opportunity to practice and perform chest tube insertion. We sought to develop and validate a scoring tool to assess chest tube insertion competency and identify areas where training is required for PEM physicians.Methods: We developed a 40-point, 20-item (scored 0, 1, or 2) assessment tool entitled the Tool for Assessing Chest Tube Insertion Competency (TACTIC) and studied how PEM physicians and fellows scored when inserting a chest tube into a pork rib model. Participants were scored at baseline and compared to themselves after receiving targeted training using Web-based animations and presentations followed by expert instruction and practice on chest tube insertion task trainers. All insertions were video recorded and reviewed by two blinded reviewers. Eight common videos were reviewed to assess interrater reliability.Results: The TACTIC demonstrated good interrater reliability with an r2=0.86. Our cohort demonstrated a significant improvement in TACTIC scores by taking part in targeted training (precourse TACTIC=65%, 95% CI 54–76 v. postcourse TACTIC=84%, 95% CI 80–88), highlighting the construct validity of the TACTIC. Individual participants increased their TACTIC scores by an average of 17%.Conclusions: The TACTIC demonstrates good interrater reliability, content validity, and construct validity in assessing a PEM practitioner’s skill inserting chest tubes in a simulated setting.
Investigating the necessity of computed tomographic scans in children with headaches: a retrospective review
Authors: Gandhi Rohit , Lewis Evan Cole , Evans Jeanette W. , Sell Erick 
Published: July 2016

AbstractObjective: Headaches are a common problem in the pediatric population. In 2002, the American Academy of Neurology (AAN) developed guidelines on neuroimaging for patients presenting with headache. Our objective was to determine the frequency of computed tomographic (CT) scanning ordered by a range of medical practitioners for pediatric patients presenting with primary headache.Methods: A retrospective chart review was conducted at the Children’s Hospital of Eastern Ontario (CHEO), a tertiary care centre in Ontario. One hundred fifty-one records of patients referred to the outpatient neurology clinic at CHEO with ‘‘headache’’ or ‘‘migraine’’ as the primary complaint from 2004 to 2009 were randomly selected. Ninety-nine patients with normal neurologic examinations were ultimately included.Results: Thirty-four patients (34%; 95% CI 25–45) had undergone CT scanning. None of the 34 CT scans (0%; 95% CI 0–10) showed significant findings, and none changed the headache diagnosis or management. Eleven (32%) of the CT scans were ordered by CHEO neurologists, 15 (44%) by community physicians, and 8 (24%) by CHEO emergency physicians.Conclusion: A high proportion of children presenting with primary headaches and a normal neurologic examination undergo CT scanning, despite well-established AAN guidelines regarding neuroimaging. Most of these CT scans do not appear to alter diagnosis and management. A variety of non–evidencebased factors may be encouraging physicians to overinvestigate this population and, as a result, increasing the risk of adverse events due to radiation exposure. Implementing initiatives at a site-based level that promote the use of established guidelines before performing CT scanning in this population may be beneficial.
Ankylosis and pseudoankylosis of the temporomandibular joint in 10 dogs (1993–2015)
Authors: Strøm Peter , Arzi Boaz , Cissell Derek , Verstraete Frank 
Published: July 2016

SummaryObjective: To describe the clinical features and results of treatment of true ankylosis and pseudoankylosis of the temporomandibular joint in dogs.Methods: This study was a retrospective case series. Ten client-owned dogs that were presented for inability to open the mouth or a severely decreased range of motion of the temporomandibular joint were included. Information on the surgical procedures performed and the perioperative complications were documented. Three-dimensional printing of the skull was performed in four dogs.Results: Two dogs were diagnosed with temporomandibular joint ankylosis and seven dogs with pseudoankylosis. One dog had evidence of combined temporomandibular joint ankylosis and pseudoankylosis. Of the seven dogs with pseudoankylosis, six had an osseous fusion involving the zygomatic arch and mandible. Surgical treatment was performed in nine dogs and a revision surgery was needed in one dog. Follow-up ranged from five months to eight years (mean: 48.6 months). Eight out of nine dogs that were treated surgically regained the ability to open their mouth, but six dogs never regained a fully normal temporomandibular joint range of motion.Clinical significance: Temporomandibular joint ankylosis and pseudoankylosis are uncommon in the dog. Surgical treatment for temporomandibular joint ankylosis or pseudoankylosis in dogs is a successful option and carries a prognosis dependent on patient-specific abnormalities. Computed tomography complemented with three- dimensional printing is valuable for understanding the extent of abnormalities and for preoperative planning.Supplementary material for this paper is available online at http://dx.doi.org/10.3415/VCOT-15-11-0189.
Transposable element evolution in the allotetraploid Capsella bursa‐pastoris
Authors: Ågren J. Arvid , Huang Hui‐Run , Wright Stephen I. 
Published: July 2016

PREMISE OF THE STUDY:Shifts in ploidy affect the evolutionary dynamics of genomes in a myriad of ways. Population genetic theory predicts that transposable element (TE) proliferation may follow because the genomewide efficacy of selection should be reduced and the increase in gene copies may mask the deleterious effects of TE insertions. Moreover, in allopolyploids, TEs may further accumulate because of hybrid breakdown of TE silencing. However, to date the evidence of TE proliferation following an increase in ploidy is mixed, and the relative importance of relaxed selection vs. silencing breakdown remains unclear.METHODS:We used high‐coverage whole‐genome sequence data to evaluate the abundance, genomic distribution, and population frequencies of TEs in the self‐fertilizing recent allotetraploid Capsella bursa‐pastoris (Brassicaceae). We then compared the C. bursa‐pastoris TE profile with that of its two parental diploid species, outcrossing C. grandiflora and self‐fertilizing C. orientalis.KEY RESULTS:We found no evidence that C. bursa‐pastoris has experienced a large genomewide proliferation of TEs relative to its parental species. However, when centromeric regions are excluded, we found evidence of significantly higher abundance of retrotransposons in C. bursa‐pastoris along the gene‐rich chromosome arms compared with C. grandiflora and C. orientalis.CONCLUSIONS:The lack of a genomewide effect of allopolyploidy on TE abundance, combined with the increases TE abundance in gene‐rich regions, suggests that relaxed selection rather than hybrid breakdown of host silencing explains the TE accumulation in C. bursa‐pastoris.
A 2.4% DETERMINATION OF THE LOCAL VALUE OF THE HUBBLE CONSTANT*
Authors: Riess Adam G. , Macri Lucas M. , Hoffmann Samantha L. , Scolnic Dan , Casertano Stefano , Filippenko Alexei V. , Tucker Brad E. , Reid Mark J. , Jones David O. , Silverman Jeffrey M. , Chornock Ryan , Challis Peter , Yuan Wenlong , Brown Peter J. , Foley Ryan J. 
Published: July 2016

ABSTRACT
We use the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST) to reduce the uncertainty in the local value of the Hubble constant from 3.3% to 2.4%. The bulk of this improvement comes from new near-infrared (NIR) observations of Cepheid variables in 11 host galaxies of recent type Ia supernovae (SNe Ia), more than doubling the sample of reliable SNe Ia having a Cepheid-calibrated distance to a total of 19; these in turn leverage the magnitude-redshift relation based on ∼300 SNe Ia at z < 0.15. All 19 hosts as well as the megamaser system NGC 4258 have been observed with WFC3 in the optical and NIR, thus nullifying cross-instrument zeropoint errors in the relative distance estimates from Cepheids. Other noteworthy improvements include a 33% reduction in the systematic uncertainty in the maser distance to NGC 4258, a larger sample of Cepheids in the Large Magellanic Cloud (LMC), a more robust distance to the LMC based on late-type detached eclipsing binaries (DEBs), HST observations of Cepheids in M31, and new HST-based trigonometric parallaxes for Milky Way (MW) Cepheids. We consider four geometric distance calibrations of Cepheids: (i) megamasers in NGC 4258, (ii) 8 DEBs in the LMC, (iii) 15 MW Cepheids with parallaxes measured with HST/FGS, HST/WFC3 spatial scanning and/or Hipparcos, and (iv) 2 DEBs in M31. The Hubble constant from each is 72.25 ± 2.51, 72.04 ± 2.67, 76.18 ± 2.37, and 74.50 ± 3.27 km s−1 Mpc−1, respectively. Our best estimate of H
0 = 73.24 ± 1.74 km s−1 Mpc−1 combines the anchors NGC 4258, MW, and LMC, yielding a 2.4% determination (all quoted uncertainties include fully propagated statistical and systematic components). This value is 3.4σ higher than 66.93 ± 0.62 km s−1 Mpc−1 predicted by ΛCDM with 3 neutrino flavors having a mass of 0.06 eV and the new Planck data, but the discrepancy reduces to 2.1σ relative to the prediction of 69.3 ± 0.7 km s−1 Mpc−1 based on the comparably precise combination of WMAP+ACT+SPT+BAO observations, suggesting that systematic uncertainties in CMB radiation measurements may play a role in the tension. If we take the conflict between Planck high-redshift measurements and our local determination of H
0 at face value, one plausible explanation could involve an additional source of dark radiation in the early universe in the range of ΔN
eff ≈ 0.4–1. We anticipate further significant improvements in H
0 from upcoming parallax measurements of long-period MW Cepheids.
THE RED AND FEATURELESS OUTER DISKS OF NEARBY SPIRAL GALAXIES
Authors: Watkins Aaron E. , Mihos J. Christopher , Harding Paul 
Published: July 2016

ABSTRACT
We present results from deep, wide-field surface photometry of three nearby (D = 4–7 Mpc) spiral galaxies: M94 (NGC 4736), M64 (NGC 4826), and M106 (NGC 4258). Our imaging reaches a limiting surface brightness of

∼ 28–30 mag arcsec−2 and probes colors down to

∼ 27.5 mag arcsec−2. We compare our broadband optical data to available ultraviolet and high column density H i data to better constrain the star-forming history and stellar populations of the outermost parts of each galaxy’s disk. Each galaxy has a well-defined radius beyond which little star formation occurs and the disk light appears both azimuthally smooth and red in color, suggestive of old, well-mixed stellar populations. Given the lack of ongoing star formation or blue stellar populations in these galaxies’ outer disks, the most likely mechanisms for their formation are dynamical processes such as disk heating or radial migration, rather than inside-out growth of the disks. This is also implied by the similarity in outer disk properties despite each galaxy showing distinct levels of environmental influence, from a purely isolated galaxy (M94) to one experiencing weak tidal perturbations from its satellite galaxies (M106) to a galaxy recovering from a recent merger (M64), suggesting that a variety of evolutionary histories can yield similar outer disk structure. While this suggests a common secular mechanism for outer disk formation, the large extent of these smooth, red stellar populations—which reach several disk scale lengths beyond the galaxies’ spiral structure—may challenge models of radial migration given the lack of any nonaxisymmetric forcing at such large radii.
THE HOST GALAXY PROPERTIES OF VARIABILITY SELECTED AGN IN THE PAN-STARRS1 MEDIUM DEEP SURVEY
Authors: Heinis S. , Gezari S. , Kumar S. , Burgett W. S. , Flewelling H. , Huber M. E. , Kaiser N. , Wainscoat R. J. , Waters C. 
Published: July 2016

ABSTRACT
We study the properties of 975 active galactic nuclei (AGNs) selected by variability in the Pan-STARRS1 Medium deep Survey. Using complementary multi-wavelength data from the ultraviolet to the far-infrared, we use spectral energy distribution fitting to determine the AGN and host properties at z < 1 and compare to a well-matched control sample. We confirm the trend previously observed: that the variability amplitude decreases with AGN luminosity, but we also observe that the slope of this relation steepens with wavelength, resulting in a “redder when brighter” trend at low luminosities. Our results show that AGNs are hosted by more massive hosts than control sample galaxies, while the rest frame dust-corrected NUV − r color distribution of AGN hosts is similar to control galaxies. We find a positive correlation between the AGN luminosity and star formation rate (SFR), independent of redshift. AGN hosts populate the entire range of SFRs within and outside of the Main Sequence of star-forming galaxies. Comparing the distribution of AGN hosts and control galaxies, we show that AGN hosts are less likely to be hosted by quiescent galaxies and more likely to be hosted by Main Sequence or starburst galaxies.
Lack of IL-1 Receptor–Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection
Authors: Marinho Fábio V. , Fahel Júlia S. , Scanga Charles A. , Gomes Marco Tulio R. , Guimarães Gabriela , Carvalho Gabrielle R. M. , Morales Stefanny V. , Báfica André , Oliveira Sergio Costa 
Published: July 2016

Abstract
The Toll-like and IL-1 family receptors play critical roles in innate and adaptive immunity against intracellular pathogens. Although previous data demonstrated the importance of TLRs and IL-1R signaling events for the establishment of an effective immune response to mycobacteria, the possible function of the adaptor molecule IL-1R–associated kinase (IRAK)-4 against this pathogen has not been addressed. In this study, we determined the role of IRAK-4 in signaling pathways responsible for controlling mycobacterial infections. This kinase is important for the production of IL-12 and TNF-α by macrophages and dendritic cells exposed to mycobacteria. Moreover, Mycobacterium bovis–infected IRAK-4–knockout macrophages displayed impaired MAPK and NF-κB activation. IL-1β secretion and caspase-1 activation were also dependent on IRAK-4 signaling. Mice lacking IRAK-4 showed increased M. bovis burden in spleen, liver, and lungs and smaller liver granulomas during 60 d of infection compared with wild-type mice. Furthermore, 80% of IRAK-4−/− mice succumbed to virulent M. tuberculosis within 100 d following low-dose infection. This increased susceptibility to mycobacteria correlated with reduced IFN-γ/TNF-α recall responses by splenocytes, as well as fewer IL-12p70–producing APCs. Additionally, we observed that IRAK-4 is also important for the production of IFN-γ by CD4+ T cells from infected mice. Finally, THP-1 cells treated with an IRAK-4 inhibitor and exposed to M. bovis showed reduced TNF-α and IL-12, suggesting that the results found in mice can be extended to humans. In summary, these data demonstrate that IRAK-4 is essential for innate and adaptive immunity and necessary for efficient control of mycobacterial infections.
Privacidad: cómo se entiende y se gestiona en Facebook. Estudio de caso de jóvenes chilenos
Authors: Moreno-Becerra Tabita , Gajardo-León Constanza , Parra-Ortiz Elizabeth 
Published: July 2016

os usuarios de Facebook comparten continuamente variada información, incluyendo datos personales hasta su localización física. Dichas prácticas alteran el concepto de privacidad, pues los datos permanecen disponibles para los contactos pero son también muchas veces de acceso público.Metodología. Este artículo analiza el modo en que adultos jóvenes (25-34 años), en Chile, concilian la difusión de información personal a través de Facebook con el cuidado de su privacidad. Mediante un estudio de caso se entrevistó en profundidad a 20 jóvenes de Concepción. Resultados y conclusiones. Los resultados muestran que los jóvenes seleccionan con cuidado la información que podrán consultar sus contactos y adoptan diferentes estrategias para proteger su información personal y definir quiénes accederán a contenido específico. En concordancia y dado ese sentido de control que consideran tener sobre la información que comparten, estos jóvenes no perciben una amenaza a su privacidad social (vigilancia social), pero desconfían y sienten amenazada su privacidad institucional (vigilancia institucional).
Do Current Lattice Boltzmann Methods for Diffusion and Advection-Diffusion Equations Respect Maximum Principle and the Non-Negative Constraint?
Authors: Karimi S. , Nakshatrala K. B. 
Published: July 2016

AbstractThe Lattice Boltzmann Method (LBM) has established itself as a popular numerical method in computational fluid dynamics. Several advancements have been recently made in LBM, which include multiple-relaxation-time LBM to simulate anisotropic advection-diffusion processes. Because of the importance of LBM simulations for transport problems in subsurface and reactive flows, one needs to study the accuracy and structure preserving properties of numerical solutions under the LBM. The solutions to advective-diffusive systems are known to satisfy maximum principles, comparison principles, the non-negative constraint, and the decay property. In this paper, using several numerical experiments, it will be shown that current single- and multiple-relaxation-time lattice Boltzmann methodsfailto preserve these mathematical properties for transient diffusion-type equations. We will also show that these violations may not be removed by simply refining the discretization parameters. More importantly, it will be shown that meeting stability conditions alone does not guarantee the preservation of the aforementioned mathematical principles and physical constraints in the discrete setting. A discussion on the source of these violations and possible approaches to avoid them is included. A condition to guarantee the non-negativity of concentration under LBM in the case of isotropic diffusion is also derived. The impact of this research is twofold.First, the study poses several outstanding research problems, which should guide researchers to develop LBM-based formulations for transport problems that respect important mathematical properties and physical constraints in the discrete setting. This paper can also serve as a good source of benchmark problems for such future research endeavors.Second, this study cautions the practitioners of the LBM for transport problems with the associated numerical deficiencies of the LBM, and provides guidelines for performing predictive simulations of advective-diffusive processes using the LBM.
Analysis of the Effect of Spatial Uncertainties on the Dynamic Behavior of Electrostatic Microactuators
Authors: Alwan Aravind , Aluru Narayana R. 
Published: July 2016

AbstractThis paper examines the effect of spatial roughness on the dynamical behaviour of electrostatic microactuators. We develop a comprehensive physical model that comprises a nonlinear electrostatic actuation force aswell as a squeeze-film damping term to accurately simulate the dynamical behavior of a cantilever beam actuator. Spatial roughness is modeled as a nonstationary stochastic process whose parameters can be estimated from profilometric measurements. We propagate the stochastic model through the physical system and examine the resulting uncertainty in the dynamical behavior that manifests as a variation in the quality factor of the device. We identify two distinct, yet coupled, modes of uncertainty propagation in the system, that result from the roughness causing variation in the electrostatic actuation force and the damping pressure, respectively. By artificially turning off each of these modes of propagation in sequence, we demonstrate that the variation in the damping pressure has a greater effect on the damping ratio than that arising from the electrostatic force. Comparison with similar simulations performed using a simplified mass-spring-damper model show that the coupling between these two mechanisms can be captured only when the physical model includes the primary nonlinear interactions along with a proper treatment of spatial variations. We also highlight the difference between nonstationary and stationary covariance formulations by showing that the stationary model is unable to properly capture the full range of variation as compared to its nonstationary counterpart.
Glass-ionomer Cements in Restorative Dentistry: A Critical Appraisal
Authors: Almuhaiza Mohammed 
Published: July 2016

ABSTRACTGlass-ionomer cements (GICs) are mainstream restorative materials that are bioactive and have a wide range of uses, such as lining, bonding, sealing, luting or restoring a tooth. Although the major characteristics of GICs for the wider applications in dentistry are adhesion to tooth structure, fluoride releasing capacity and tooth-colored restorations, the sensitivity to moisture, inherent opacity, long-term wear and strength are not as adequate as desired. They have undergone remarkable changes in their composition, such as the addition of metallic ions or resin components to their composition, which contributed to improve their physical properties and diversified their use as a restorative material of great clinical applicability. The lightcured polymer reinforced materials appear to have substantial benefits, while retaining the advantages of fluoride release and adhesion. Further research should be directed towards improving the properties, such as strength and esthetics without altering its inherent qualities, such as adhesion and fluoride releasing capabilities.How to cite this articleAlmuhaiza M. Glass-ionomer Cements in Restorative Dentistry: A Critical Appraisal. J Contemp Dent Pract 2016;17(4):331-336.