bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing fragility and consequence models for buildings in the Groningen field
Authors: Crowley Helen , Pinho Rui , Polidoro Barbara , van Elk Jan 
Published: January 2018

AbstractThis paper describes the ongoing experimental and analytical activities that are being carried out to develop fatality and consequence models for the estimation of ‘Inside Local Personal Risk’ (ILPR) of buildings within the Groningen field. ILPR is defined as the annual probability of fatality for a hypothetical person who is continuously present without protection inside a building. In order to be able to estimate this risk metric, a robust estimate of the probability of collapse of structural and non-structural elements within a building is needed, as these have been found to be the greatest drivers of fatality risk.To estimate the collapse potential of buildings in Groningen, structural numerical models of a number of representative case studies have been developed and calibrated throughin situand laboratory testing on materials, connections, structural components and even full-scale buildings. These numerical models are then subjected to increased levels of ground shaking to estimate the probability of collapse, and the associated consequences are estimated from the observed collapse mechanisms.
Genetic diversity of Blastocystis in non-primate animals
Authors: Betts Emma L. , Gentekaki Eleni , Thomasz Adele , Breakell Vicki , Carpenter Angus I. , Tsaousis Anastasios D. 
Published: January 2018

AbstractBlastocystis is an anaerobic protist, commonly inhabiting the intestinal tract of both humans and other animals. Blastocystis is extremely diverse comprising 17 genetically distinct subtypes in mammals and birds. Pathogenicity of this enteric microbe is currently disputed and knowledge regarding its distribution, diversity and zoonotic potential is fragmentary. Most research has focused on Blastocystis from primates, while sampling from other animals remains limited. Herein, we investigated the prevalence and distribution of Blastocystis in animals held within a conservation park in South East England. A total of 118 samples were collected from 27 vertebrate species. The barcoding region of the small-subunit ribosomal RNA was used for molecular identification and subtyping. Forty one per cent of the species were sequence positive for Blastocystis indicating a high prevalence and wide distribution among the animals in the park. Six subtypes were identified, one of which is potentially novel. Moreover, the majority of animals were asymptomatic carriers, suggesting that Blastocystis is not pathogenic in animals. This study provides a thorough investigation of Blastocystis prevalence within a wildlife park in the UK and can be used as a platform for further investigations on the distribution of other eukaryotic gut microbes.
OFFICIAL BOLIVIAN TRADE STATISTICS (1910-1949): LANDLOCKNESS AND THE LIMITS OF A STANDARD ACCURACY APPROACH
Authors: Peres-Cajías José Alejandro , Carreras-Marín Anna 
Published: January 2018

AbstractThis paper aims to evaluate the accuracy of official Bolivian foreign trade statistics. Results show large discrepancies between Bolivian records and those of its main trade partners during the First World War. Whereas the gap decreased thereafter, it stayed particularly high in the case of exports. This seems to be explained by mistakes in the geographical assignment by the trade partners rather than by an overvaluation of official Bolivian figures. This suggests that landlockness may have had a significant negative effect on the accuracy of trade statistics from the, a priori, more reliable countries. The study also helps to revisit the debate concerning the effect that tin exploitation had on the rest of the Bolivian economy during the first half of the 20th century.
Efficiency relationship between initiation of HNS-IV and nanosecond pulsed laser-driven flyer plates of layered structure
Authors: Guo Wei , Wu Lizhi , He Nianbai , Chen Shaojie , Zhang Wei , Shen Ruiqi , Ye Yinghua 
Published: January 2018

AbstractThree types of multilayer flyer energy conversion elements (MFECEs) through integrating different laser pulse absorption/ablation layer of nano-film materials into a laser-driven flyer plates between thermal barrier of alumina and transparent substrate have been investigated in this study. The relationships among the velocity of flyer plates, initiation performance of hexanitrostilbene (HNS-IV), and initiation energy were analyzed, comparing with single-layer Al flyer plate. The photonics Doppler velocimetry and James criterion were utilized in the experiments to characterize the velocity of flyer plates and shock initiation of laser-driven flyer detonator, respectively. The surface reflectivity measurements of the Al, C/Al and Mg/Al layers were performed using laser reflectivity. HNS-IV without initiation was analyzed by scanning electron microscope and energy dispersive spectrometer. Caused by aluminum/alumina/aluminum (Al/Al2O3/Al) flyer plate, the residual fragments were found in the pit on the surface of charge. The results obtained were shows that three types of multilayer flyer plates can initiate HNS-IV successfully under the lower laser pulse energy, although all four kinds of flyer plates have successfully initiated HNS-IV with laser pulse energy in the range of 53.80–166.80 mJ. Changing the ablation layer structure and adding thermal insulation layer to the multilayer flyer plates, reduces the shock initiation laser pulse energy of HNS-IV to 53.80 mJ. The laser-driven flyer detonator has significant advantages in providing safety and reliability, especially in a strong electromagnetic environment. The MFECEs of laser-driven flyer detonator exhibited a high level of integration and proved to have promoted laser-driven energy coupling rate, which can significantly be used to improve the performance of the laser-driven flyer detonator in military and civilian applications.
Missing Effect of Party Cues in Japan: Evidence from a Survey Experiment
Authors: KOBAYASHI TETSURO , YOKOYAMA TOMOYA 
Published: January 2018

AbstractFor voters with bounded rationality to emulate the formation of policy preferences under full information, party cues provide effective heuristics. Although the effect of party cuing has been robustly established in US-centered studies, the literature indicates that the characteristics of modern US politics, such as political polarization, magnify the effect of party cues. Therefore, the effect of party cues has been subject to only lenient empirical scrutiny, as empirical evidence exists primarily for the US. The present study aims to test the generalizability of the effect of party cues by focusing on Japan, where the ideological positions of parties have become increasingly vague. Furthermore, in light of the fact that the media system in Japan is more stable and ideologically polarized than its party system, we also test whether press cues (i.e. newspaper names) serve as substitutes for party cues. A survey experiment demonstrates that the effects of party and press cues in Japan are muted, and therefore these two types of cues do not serve as effective shortcuts in forming policy preferences. These results indicate that issue voting based on cognitive heuristics is difficult under an unstable multiparty system. Therefore, the extant literature on party cues that presupposes the US-style party system cannot be easily generalized to other political contexts.
Oil Crimes, National Security, and the Nigerian State, 1999–2015
Authors: EZIRIM GERALD EKENEDIRICHUKWU 
Published: January 2018

AbstractThe discovery of oil in commercial quantity in Nigeria in 1956 ushered in a period characterized by endemic crises of oil rents management and corporate insecurity. From 1999, democratic renewal, backed by excess oil rents returns, made the popular democratic control of oil wealth critical. The consequent rentier management of oil wealth, excluding the citizens and their huge expectations occasioned threats to national security, thus punctuating limited democratic control of oil wealth, or lack of it. Employing the ex-post-facto research design, primary data for the study were generated from focus group discussions with experts in the oil sector, while other sources were from observations of the Nigerian Navy, Nigerian Customs Service, Nigerian Police, Nigerian National Petroleum Corporation, Nigerian Extractive Industries Transparency Initiative, National Bureau of Statistics, and the Central Bank of Nigeria. Logical induction was used to analyze the data. Anchored on a frustration-aggression conceptual and theoretical framework, the study found that deprivation of oil benefits to Nigerian citizens manifested in illegal oil bunkering, pipeline vandalization, cross-border smuggling of petroleum products, attacks on oil installations, kidnapping, and piracy, with attendant threats to national security.
Susceptibility of three orthopteran species to infection by Metarhizium acridum (Hypocreales: Clavicipitaceae)
Authors: Schmidt Francisco Guilherme Vergolino , Conceição Pâmela de Jesus , Benito Norton Polo , Lopes Rogerio Biaggioni 
Published: January 2018

AbstractOutbreaks of three orthopteran species—Tropidacris collaris(Stoll),Cornops frenatum frenatum(Marschall) andParascopas obesus(Giglio-Tos)—occurred in three different regions of Brazil during the summers of 2012 and 2013. Insects were observed causing severe damage in commercial crops and subsistence farming areas. In this study, the three species were shown to be susceptible to infection with an oil-based formulation of the fungusMetarhizium acridumunder laboratory conditions. In this article, we briefly discuss insect mortality levels for each species and behavioural response to infection. This is the first report of the pathogenicity of the entomopathogenic fungusM. acridumtoP. obesus,C. f. frenatumandT. collaris.
Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes
Authors: Kathayat Rahul S. , Cao Yang , Elvira Pablo D. , Sandoz Patrick A. , Zaballa María-Eugenia , Springer Maya Z. , Drake Lauren E. , Macleod Kay F. , van der Goot F. Gisou , Dickinson Bryan C. 
Published: January 2018

AbstractThe reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational modification (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing an intriguing potential connection between metabolic lipids and mitochondrial regulation. However, it is unknown whether and/or how mitochondrial S-palmitoylation is regulated. Here we report the development of mitoDPPs, targeted fluorescent probes that measure the activity levels of “erasers” of S-palmitoylation, acyl-protein thioesterases (APTs), within mitochondria of live cells. Using mitoDPPs, we discover active S-depalmitoylation in mitochondria, in part mediated by APT1, an S-depalmitoylase previously thought to reside in the cytosol and on the Golgi apparatus. We also find that perturbation of long-chain acyl-CoA cytoplasm and mitochondrial regulatory proteins, respectively, results in selective responses from cytosolic and mitochondrial S-depalmitoylases. Altogether, this work reveals that mitochondrial S-palmitoylation is actively regulated by “eraser” enzymes that respond to alterations in mitochondrial lipid homeostasis.
A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry
Authors: Ullman Julie C. , Yang Jing , Sullivan Michael , Bendor Jacob , Levy Jonathan , Pham Ellen , Silm Katlin , Seifikar Helia , Sohal Vikaas S. , Nicoll Roger A. , Edwards Robert H. 
Published: January 2018

AbstractPsychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na+/H+ exchanger NHE9 in both autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). Plasma membrane NHEs regulate cytosolic pH, but the role of intracellular isoforms has remained unclear. We now find that inactivation of NHE9 in mice reproduces behavioral features of ASD including impaired social interaction, repetitive behaviors, and altered sensory processing. Physiological characterization reveals hyperacidic endosomes, a cell-autonomous defect in glutamate receptor expression and impaired neurotransmitter release due to a defect in presynaptic Ca2+ entry. Acute inhibition of synaptic vesicle acidification rescues release but without affecting the primary defect due to loss of NHE9.
Similar neural responses predict friendship
Authors: Parkinson Carolyn , Kleinbaum Adam M. , Wheatley Thalia 
Published: January 2018

AbstractHuman social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship, and more generally, social network proximity, is associated with increased similarity of real-time mental responding, we used functional magnetic resonance imaging to scan subjects’ brains during free viewing of naturalistic movies. Here we show evidence for neural homophily: neural responses when viewing audiovisual movies are exceptionally similar among friends, and that similarity decreases with increasing distance in a real-world social network. These results suggest that we are exceptionally similar to our friends in how we perceive and respond to the world around us, which has implications for interpersonal influence and attraction.
First experimental observations on melting and chemical modification of volcanic ash during lightning interaction
Authors: Mueller S. P. , Helo C. , Keller F. , Taddeucci J. , Castro J. M. 
Published: January 2018

AbstractElectrification in volcanic ash plumes often leads to syn-eruptive lightning discharges. High temperatures in and around lightning plasma channels have the potential to chemically alter, re-melt, and possibly volatilize ash fragments in the eruption cloud. In this study, we experimentally simulate temperature conditions of volcanic lightning in the laboratory, and systematically investigate the effects of rapid melting on the morphology and chemical composition of ash. Samples of different size and composition are ejected towards an artificially generated electrical arc. Post-experiment ash morphologies include fully melted spheres, partially melted particles, agglomerates, and vesiculated particles. High-speed imaging reveals various processes occurring during the short lightning-ash interactions, such as particle melting and rounding, foaming, and explosive particle fragmentation. Chemical analyses of the flash-melted particles reveal considerable bulk loss of Cl, S, P and Na through thermal vaporization. Element distribution patterns suggest convection as a key process of element transport from the interior of the melt droplet to rim where volatiles are lost. Modeling the degree of sodium loss delivers maximum melt temperatures between 3290 and 3490 K. Our results imply that natural lighting strikes may be an important agent of syn-eruptive morphological and chemical processing of volcanic ash.
Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation
Authors: Zou Yanan , Chen Zixuan , Jennings Brett L. , Zhao Guannan , Gu Qingqing , Bhattacharya Anindya , Cui Yan , Yu Bo , Malik Kafait U. , Yue Junming 
Published: January 2018

AbstractDiGeorge syndrome chromosomal region 8 (DGCR8), a double-stranded-RNA-binding protein, participates in the miRNA biogenesis pathway and contributes to miRNA maturation by interacting with the RNAase III enzyme Drosha in cell nuclei. To investigate the role of DGCR8 in vascular smooth muscle cells (VSMCs) at the postnatal stages, we generated tamoxifen-inducible VSMC specific knockout (iKO) mice by crossing DGCR8loxp/loxp with VSMC specific tamoxifen-inducible Cre transgenic mice SMA-Cre-ERT2. DGCR8iKO mice display reduced body weight one month following tamoxifen treatment and died around 3 months. Blood pressure and vascular reactivity were significantly reduced in DGCR8iKO mice compared to control. Furthermore, loss of DGCR8 in VSMCs inhibited cell proliferation, migration and neointima formation. VSMC differentiation marker genes, including SMA and SM22, were downregulated in DGCR8 iKO mice. The majority of miRNAs were downregulated in DGCR8iKO mice. Disruption of the DGCR8-mediated miRNA biogenesis pathway attenuated multiple signaling pathways including ERK1/2 and AKT. Our results demonstrate that the DGCR8-mediated miRNA pathway is required for maintaining blood pressure, vascular reactivity and vascular wall remodeling at the postnatal stages.
Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose
Authors: Chen Peng , Chen Fuchao , Zhou Benhong 
Published: January 2018

AbstractAccumulating evidence has suggested that oxidative stress and apoptosis are involved in the ageing process. D-galactose (gal) has been reported to cause symptoms of ageing in rats, accompanied by liver and brain injuries. Our study aimed to investigate the potential antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid and to explore how these effects act on rats in a D-gal-induced ageing model. Ageing was induced by subcutaneous injection of D-gal (100 mg/kg/d for 8 weeks). Ellagic acid was simultaneously administered to the D-gal-induced ageing rats once daily by intragastric gavage. Finally, the mental condition, body weight, organ index, levels of inflammatory cytokines, antioxidative enzymes, and liver function, as well as the expression of pro- and anti-apoptotic proteins, were monitored. Our results showed that ellagic acid could improve the mental condition, body weight, organ index and significantly decrease the levels of inflammatory cytokines, normalize the activities of antioxidative enzymes, and modulate the expression of apoptotic protein in ageing rats. In conclusion, the results of this study illustrate that ellagic acid was suitable for the treatment of some ageing-associated problems, such as oxidative stress, and had beneficial effects for age-associated diseases.
A specialized fungal parasite (Massospora cicadina) hijacks the sexual signals of periodical cicadas (Hemiptera: Cicadidae: Magicicada)
Authors: Cooley John R. , Marshall David C. , Hill Kathy B. R. 
Published: January 2018

AbstractMale periodical cicadas (Magicicada spp.) infected with conidiospore-producing (“Stage I”) infections of the entomopathogenic fungus Massospora cicadina exhibit precisely timed wing-flick signaling behavior normally seen only in sexually receptive female cicadas. Male wing-flicks attract copulation attempts from conspecific males in the chorus; close contact apparently spreads the infective conidiospores. In contrast, males with “Stage II” infections that produce resting spores that wait for the next cicada generation do not produce female-specific signals. We propose that these complex fungus-induced behavioral changes, which resemble apparently independently derived changes in other cicada-Massospora systems, represent a fungus “extended phenotype” that hijacks cicadas, turning them into vehicles for fungus transmission at the expense of the cicadas’ own interests.
Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent
Authors: Smirnova Julia , Kabin Ekaterina , Järving Ivar , Bragina Olga , Tõugu Vello , Plitz Thomas , Palumaa Peep 
Published: January 2018

AbstractWilson disease is an autosomal recessive genetic disorder caused by loss-of-function mutations in the P-type copper ATPase, ATP7B, which leads to toxic accumulation of copper mainly in the liver and brain. Wilson disease is treatable, primarily by copper-chelation therapy, which promotes copper excretion. Although several de-coppering drugs are currently available, their Cu(I)-binding affinities have not been quantitatively characterized. Here we determined the Cu(I)-binding affinities of five major de-coppering drugs – D-penicillamine, trientine, 2,3-dimercapto-1-propanol, meso-2,3-dimercaptosuccinate and tetrathiomolybdate – by exploring their ability to extract Cu(I) ions from two Cu(I)-binding proteins, the copper chaperone for cytochrome c oxidase, Cox17, and metallothionein. We report that the Cu(I)-binding affinity of these drugs varies by four orders of magnitude and correlates positively with the number of sulfur atoms in the drug molecule and negatively with the number of atoms separating two SH groups. Based on the analysis of structure-activity relationship and determined Cu(I)-binding affinity, we hypothesize that the endogenous biologically active substance, α-lipoic acid, may be suitable for the treatment of Wilson disease. Our hypothesis is supported by cell culture experiments where α-lipoic acid protected hepatic cells from copper toxicity. These results provide a basis for elaboration of new generation drugs that may provide better therapeutic outcomes.
3-D micro-architecture and mechanical response of soil cemented via microbial-induced calcite precipitation
Authors: Terzis Dimitrios , Laloui Lyesse 
Published: January 2018

AbstractWe introduce the application of microbial-induced calcite precipitation via the ureolytic soil bacterium Sporosarcina Pasteurii in freeze-dried form, as a means of enhancing overall MICP efficiency and reproducibility for geotechnical engineering applications. We show that the execution of urea hydrolysis and CaCO3precipitation persist as a “cell-free” mechanism upon the complete breakdown of rehydrated cell clusters. Further, strength and stiffness parameters of bio-cemented sands are determined. Medium-grained bio-cemented sand yields compressive strengths up to 12 MPa while, surprisingly, fine-grained sand yields up to 2.5 MPa for similar bond contents. To understand the observed discrepancies, we undertake a systematic study of the bio-cemented material’s microstructure, by combining a series of microstructural inspection tools. The study extends beyond conventional qualitative and textural characterization and provides with new insight into the material’s peculiar 3D micro-architecture. We apply a new methodology towards quantifying crucial microscopic characteristics such as the particle sizes of the crystalline bond lattice, the bond-grain contacts and particle orientations. Bonds are found to exhibit distinctive geometries and morphologies when MICP applies to different base materials. We thus contribute to the debate on the importance of factors affecting: (i) MICP efficiency, (ii) the mechanical response and (iii) peculiar micro-architecture of bio-improved geo-materials.