bluuebunny/crossref_metadata_2025_split huggingface dataset:
The GTC exoplanet transit spectroscopy survey
Authors: Parviainen H. , Pallé E. , Chen G. , Nortmann L. , Murgas F. , Nowak G. , Aigrain S. , Booth A. , Abazorius M. , Iro N. 
Published: September 2017

Aims. We set out to study the atmosphere of WASP-80b, a warm inflated gas giant with an equilibrium temperature of ~800 K, using ground-based transmission spectroscopy covering the spectral range from 520 to 910 nm. The observations allow us to probe the existence and abundance of K and Na in WASP-80b’s atmosphere, existence of high-altitude clouds, and Rayleigh-scattering in the blue end of the spectrum.
Methods. We observed two spectroscopic time series of WASP-80b transits with the OSIRIS spectrograph installed in the Gran Telescopio Canarias (GTC), and use the observations to estimate the planet’s transmission spectrum between 520 nm and 910 nm in 20 nm-wide passbands, and around the K I and Na I resonance doublets in 6 nm-wide passbands. We jointly model three previously published broadband datasets consisting of 27 light curves, prior to a transmission spectroscopy analysis in order to obtain improved estimates of the planet’s orbital parameters, average radius ratio, and stellar density. The parameter posteriors from the broadband analysis are used to set informative priors on the transmission spectroscopy analysis. The final transmission spectroscopy analyses are carried out jointly for the two nights using a divide-by-white approach to remove the common-mode systematics, and Gaussian processes to model the residual wavelength-dependent systematics.
Results. We recover a flat transmission spectrum with no evidence of Rayleigh scattering or K I or Na I absorption, and obtain an improved system characterisation as a by-product of the broadband- and GTC-dataset modelling. The transmission spectra estimated separately from the two observing runs are consistent with each other, as are the transmission spectra estimated using either a parametric or nonparametric systematics model. The flat transmission spectrum favours an atmosphere model with high-altitude clouds over cloud-free models with stellar or sub-stellar metallicities.
Conclusions. Our results disagree with the recently published discovery of strong K I absorption in WASP-80b’s atmosphere based on ground-based transmission spectroscopy with FORS2 at VLT.
The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis
Authors: Xu Jinling , Lin Yanyan , Zhou Hui , Zhao Linshuang , Xiang Guangda 
Published: September 2017

AbstractMany inconsistent findings are reported on the correlation between circulating betatrophin and insulin resistance in the different population. The aim of this analysis was to explore the correlation between the level of betatrophin and insulin resistance in the general population. The databases of PubMed, EMBASE, and the Cochrane Library (inception to October 26, 2016) were searched without language restrictions for publications that reported studies on associations between betatrophin and insulin resistance in adults. Subgroup analyses were performed to investigate potential sources of heterogeneity. The pooled effect size was calculated using a random-effects model. Twenty-five studies were included in this meta-analysis. Meta-analysis showed that betatrophin was positively and significantly correlated with insulin resistance (r=0.16, 95% CI: 0.08–0.25). When all participants were divided into DM, GDM, and Non-DM groups, this association was also significant in T2DM, GDM, and Non-DM participants (T2DM: r=0.09, 95% CI: 0.01–0.17; I
2=45.1%; GDM: r=0.39, 95% CI: 0.24–0.55; I
2=0.0%; non-DM: r=0.15, 95% CI: 0.04–0.26; I
2=89.3%), and it was obvious that heterogeneity existed in Non-DM group (I
2=89.3%, p<0.001). Subgroup analysis revealed that gender, serum sample and ELISA kits for full-length betatrophin had significant influence on the association between betatrophin and insulin resistance. In conclusion, the level of circulating betatrophin is positively associated with insulin resistance in the general population, especially in T2DM and GDM patients. Gender, serum sample, and ELISA kits for full-length betatrophin may affect this association. More large-scale studies are needed to determine whether improving insulin resistance concomitantly declines betatrophin levels in different diseases.
Hopping and Landing Performance in Male Youth Soccer Players: Effects of Age and Maturation
Authors: Read Paul , Oliver Jon , De Ste Croix Mark , Myer Gregory , Lloyd Rhodri 
Published: September 2017

AbstractQuantifying hopping and landing performances can assist coaches in identifying young male soccer players who may be at increased risk of injury. The influence of chronological age and maturation on these measures in this population is unknown. Single leg hop for distance (SLHD) and 75% horizontal hop and stick landing force (75%Hop) were examined in a cross-sectional sample (N=400) of elite male youth soccer players. Between-group differences for both chronological age (U11–U18) and stage of maturation (pre-, circa- or post-peak height velocity (PHV)) were analyzed. Absolute 75%Hop increased with both age and maturation. Apart from the U18s, pre-PHV and U11–U12 players displayed the greatest relative landing forces compared to all other groups (p<0.001; d=0.56–0.93). Absolute and relative SLHD were greatest in the U18s and post-PHV players (p<0.001; d=0.35–2.04). A trend showed increased SLHD with each consecutive age group although a reduction in performance was identified in the U13s (d=0.50–0.59). High volumes of accumulated soccer participation in the U18s may lead to altered landing strategies indicative of high injury risk. A temporary reduction in hop performance in the U13s may also be linked to a period of adolescent awkwardness.
Training der oberen Extremitäten mit einem Roboterball bei Schlaganfallpatienten
Authors: Neuendorf Tilo , Zschäbitz Daniel , Nitzsche Nico , Schulz Henry 
Published: September 2017

Zusammenfassung
Hintergrund Technik-gestützte Bewegungstherapie kann dazu beitragen, die charakteristischen Symptome der oberen Extremitäten infolge eines Schlaganfalls durch die Fähigkeit der neuronalen Reorganisation zu rehabilitieren. Der Roboterball „Sphero 2.0“ wurde als potenziell geeignetes innovatives Exergaming-Instrument festgestellt und zum ersten Mal in der Neurorehabilitation angewendet.
Ziel der Arbeit Das entwickelte Therapiekonzept mit dem Roboterball soll erprobt und mögliche Effekte auf motorische Parameter geprüft werden. Patientenangaben sollen dazu beitragen, den Einsatz in der Rehabilitation zu testen sowie Auswirkungen einer mehrwöchigen Anwendung zu überprüfen. Außerdem wird die technische Eignung des Roboterballs bewertet.
Methoden Zwölf Schlaganfallpatienten (62,3 ± 11,8 Jahre, 170,8 ± 10,9 cm, 82,5 ± 16,6 kg, 6,37 ± 5,53 Monate post-stroke) trainierten an 24 Einheiten in 12 Wochen zweimal pro Woche für 45 min mit dem Roboterball. Bisherige Therapiemaßnahmen wurden ergänzt. Vor und nach der Intervention wurden Greifkraft, unilaterale Geschicklichkeit, Krankheitsempfinden, kognitiver Status sowie Technikaffinität getestet.
Ergebnisse 10 Patienten konnten die Intervention abschließen und erzielten signifikante Verbesserungen der Greifkraft (p = 0,007, d = 0,51) und der unilateralen Geschicklichkeit (p = 0,002, d = 0,44) bei reduziert wahrgenommenen Krankheitsbeschwerden (p = 0,002, d = −1,12). Der Roboterball wurde mit 92,3 ± 2,5 von maximal 100 Punkten als exzellent bewertet.
Diskussion Sehr stark und schwach betroffene Patienten scheinen von den allgemein positiven Ergebnissen weniger zu profitieren als moderat eingeschränkte. Konkrete Verbesserungen im Alltag tragen zur hohen Motivation für das Training mit dem Roboterball bei. Die Therapieinhalte können variabel gestaltet und bei unterschiedlich stark betroffenen Anwendern erfolgreich angewendet werden. Die Ergebnisse sollten im nächsten Schritt mit weiteren Patienten im Crossover-Design überprüft werden.
Behandlung von Hodentumoren im klinischen Stadium I
Authors: Schrader Mark , Zengerling Friedemann 
Published: September 2017

ZusammenfassungDie Therapie von Hodentumoren im klinischen Stadium I hat sich in den letzten Jahren stark verändert. Generell ist in diesem Stadium eine
zunehmende Therapiereduktion zu verzeichnen. Einige Autoren fordern sogar, die adjuvante Therapie im klinischen Stadium I der Tumoren ganz
zu verlassen. Dieses Vorgehen wird bei Keimzelltumoren durch eine Reihe von Studien unterstützt, die eine exzellente Überlebensrate im
Rahmen einer „Surveillance only“-Strategie zeigen. Dieses Vorgehen hat jedoch auch Grenzen und erscheint nicht für alle Patienten
gleichermaßen geeignet.Der Artikel gibt einen Überblick über aktuelle Behandlungsstrategien und diskutiert die möglichen Indikationen für eine adjuvante Therapie
bei Hodentumoren im klinischen Stadium I.
Greater Internet use is not associated with faster growth in political polarization among US demographic groups
Authors: Boxell Levi , Gentzkow Matthew , Shapiro Jesse M. 
Published: September 2017

Significance
By many measures, Americans have become increasingly polarized in recent decades. We study the role of the Internet and social media in explaining this trend. We find that polarization has increased the most among the demographic groups least likely to use the Internet and social media, suggesting that the role of these factors is limited.
Comparative analysis reveals genomic features of stress-induced transcriptional readthrough
Authors: Vilborg Anna , Sabath Niv , Wiesel Yuval , Nathans Jenny , Levy-Adam Flonia , Yario Therese A. , Steitz Joan A. , Shalgi Reut 
Published: September 2017

Significance
Cells and organisms live in constantly changing environments. Therefore, cells have evolved complex mechanisms to cope with physiological and environmental stresses. Many of these mechanisms involve transcriptional responses facilitating survival and adaptation. Recent evidence documents extensive transcriptional readthrough beyond annotated gene ends in response to stress, but the role and regulation of these downstream of gene-containing transcripts (DoGs) remain elusive. Here we report that induction of transcriptional readthrough is a hallmark of the mammalian stress response. We explore its causes and consequences in a genome-wide fashion, identifying thousands of readthrough transcripts that are induced in three different stress conditions. Our results suggest potential roles for this class of transcripts in the maintenance of open chromatin under stress.
Mass: 100 mg, 10 g, 100 g, 1 kg, 10 kg and 50 kg
Authors: Kaçmaz Sevda , Davidson Stuart 
Published: September 2017

Bilateral mass comparison of mass standards of 100 mg, 2 g, 20 g, 500 g and 10 kg was carried out in 2011 to 2012 between UME and NPL. UME was the pilot laboratory. For all mass standards, the results show adequate agreement between the laboratories.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
CCQM-K126: low polarity organic in water: carbamazepine in surface water
Authors: Sin Della Wai-mei , Wong Yiu-chung , Lehmann Andreas , Schneider Rudolf J , Kakoulides Elias , Lin Teo Tang , Qinde Liu , Cabillic Julie , Lardy-fontan Sophie , Nammoonnoy Jintana , Prevoo-Franzsen Désirée , López Eduardo Emilio , Alberti Cecilia , Su Fuhai 
Published: September 2017

The key comparison CCQM-K126 low polarity organic in water: carbamazepine in surface water was coordinated by Government Laboratory Hong Kong under the auspices of the Organic Analysis Working Group (OAWG) of the Comité Consultatif pour la Quantité de Matière (CCQM).
Eight National Metrology institutes or Designated Institutes participated and participants were requested to report the mass fraction of carbamazepine in surface water study material. The surface water sample was collected in Hong Kong and was gravimetrically spiked with standard solution. This study provided the means for assessing measurement capabilities for determination of low molecular weight analytes (mass range 100-500) and low polarity (pKOW
⩽ −2) in aqueous matrix. Nine NMIs/DIs registered for the KC and one withdrew before results were submitted. Nine results were submitted by the eight participants. Eight results applied the LC-MS/MS method and Isotope Dilution Mass Spectrometry approach for quantification. BAM additionally submitted a result from ELISA that was not included in the key comparison reference values (KCRV) calculation as is provided in the report for information. One further result was not included as the participant withdrew their result from the calculation after further analysis. The assigned KCRV was the median of the seven results and was assigned a KCRV of 250.2 ng/kg with a combined standard uncertainty of 3.6 ng/kg, The k-factor for the estimation of the expanded uncertainty of the KCRVs was chosen as k = 2.
The degree of equivalence (with the KCRV) and its uncertainty was calculated for each result. Seven of the participants were able to demonstrate the ability to quantitatively determine low-polarity analyte in aqueous matrix by applying LC-MS/MS technique at a very low level.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Progress in the clinical classification of systemic sclerosis
Authors: Johnson Sindhu R. 
Published: September 2017

Purpose of review
Systemic sclerosis (SSc) subset classification criteria are a cornerstone of SSc research. Given changes in our understanding of the disease and limitations of the current criteria in the conduct of trials, the developments of new SSc subset criteria are underway.

Recent findings
This article summarizes previous iterations of SSc subset criteria, highlights current thinking about the construct underlying SSc subsets in the modern era and provides an overview of the development of new SSc subset criteria.

Summary
Using a combination of data-driven and expert-based innovative methodologies, a large international collaborative effort is developing new SSc subset criteria. It is anticipated that this new system of classification will shift the paradigm of how we study novel therapies in SSc.
Seborrheic Keratosis With Prominent Clear Cell Changes—A Rare But Important Diagnostic Variant
Authors: Long Thomas H. , Zlotnick David , Hurst Stanley L. , Argenyi Zsolt 
Published: September 2017

Abstract:
Seborrheic keratoses, although exceedingly common, occasionally have morphologic similarities to other lesions that complicate a typically straightforward diagnosis. The authors present a case of a 69-year-old man with a left shoulder lesion that displayed characteristic clinical and microscopic features of seborrheic keratosis on biopsy. However, diffuse and prominent clear cells were also noted. These stained strongly with Periodic acid–Schiff and were diastase sensitive, suggestive of glycogen accumulation and possible trichilemmal differentiation. This case is presented to demonstrate a unique and striking example of clear cell change within a seborrheic keratosis and to briefly review the published literature on this finding, which is rarely reported and demands close examination to exclude more aggressive neoplasms.
A Case of Phacomatosis Pigmentokeratotica Associated With Multiple Basal Cell Carcinomas
Authors: Loh Seung-Hee , Lew Bark-Lynn , Sim Woo-Young 
Published: September 2017

Abstract:
Phacomatosis pigmentokeratotica is a recently identified disease characterized by the coexistence of an epidermal nevus with sebaceous differentiation arranged along Blaschko lines and a speckled lentiginous nevus showing a checkerboard pattern, mostly in association with various extracutaneous defects. A 52-year-old man presented with asymptomatic ulcerative plaque on his left side of perioral area. A 2 × 2-cm–sized fleshy colored ulceration on his left perioral area was consistent with basal cell carcinoma with nevus sebaceous. Next to the ulceration, there was a light pinkish to fleshy colored papule on his left cheek that showed syringocystadenoma papilliferum. On his chin area, there was a 2 × 0.3-cm–sized skin colored papule that was consistent with trichilemmoma. Moreover, various sized light brownish macules and dark brownish papules were also located on his left side of the chest wall, back, and arm. Biopsy specimens from macules on the left side of the trunk confirmed the clinical diagnosis of speckled lentiginous nevus and multiple black papules beside that a speckled lentiginous nevus also revealed basal cell carcinomas. Herein, we present a rare case of a patient with phacomatosis pigmentokeratotica who had no extracutaneous abnormalities and who developed basal cell carcinoma, syringocystadenoma papilliferum, and trichilemmoma in nevus sebaceous on the face and speckled lentiginous nevus on the trunk. This syndrome needs adequate follow-up due to the possibility of malignant transformation.
Community General Pediatricians' Perspectives on Providing Autism Diagnoses in Ontario, Canada: A Qualitative Study
Authors: Penner Melanie , King Gillian A. , Hartman Laura , Anagnostou Evdokia , Shouldice Michelle , Hepburn Charlotte Moore 
Published: September 2017

ABSTRACT:

Objective:
Community general pediatricians (CGPs) are a potential resource to increase capacity for autism spectrum disorder (ASD) diagnostic assessments. The objective of this study was to explore factors influencing CGPs' perspectives on and practices of providing ASD diagnoses.

Methods:
This qualitative study used a constructivist modified grounded theory approach. Participants included CGPs who had attended ASD educational events or had referred a child with suspected ASD to a tertiary rehabilitation center. Individual in-depth interviews with CGPs were recorded, transcribed, and coded. An explanatory framework was developed from the data. A summary of the framework was sent to participants, and responses indicated that no changes were needed.

Results:
Eleven CGPs participated. Assessment for ASD consists of 3 stages: (1) determining the diagnosis; (2) communicating the diagnosis; and (3) managing next steps after diagnosis. Each of these stages of ASD diagnostic assessment exists within an ecological context of child/family factors, personal CGP factors, and contextual/systems factors that all influence diagnostic decision making.

Conclusion:
Community general pediatrician ASD diagnostic capacity must be considered within the larger context of ASD care. Suggestions to improve diagnostic capacity include preparing families for the diagnosis, changing CGP perceptions of ASD, providing community-based training, improving financial remuneration, and providing service navigation. Further study is needed to ensure that CGPs are providing accurate, high-quality assessments.
Use and Effectiveness of Sleep Medications by Parent Report in Individuals with Williams Syndrome
Authors: Martens Marilee A. , Seyfer Daisha L. , Andridge Rebecca R. , Coury Daniel L. 
Published: September 2017

ABSTRACT:

Objective:
Sleep disorders are common in individuals with Williams syndrome (WS), and sleep disturbance has a significant negative effect on attention, learning, and behavior. The use of sleep-inducing medicine in individuals with WS has not been widely investigated. The objective of this study was to evaluate the use and effectiveness of sleep medications among a large sample of individuals with WS by parent survey.

Methods:
A survey of the use and effectiveness of sleep medications was completed by 513 (of 2846) members of the Williams Syndrome Association. The online survey asked for the age at initiation, degree of effectiveness (helpful, somewhat helpful, and not helpful), and side effects.

Results:
One hundred thirty participants (25%) indicated that their family member with WS had taken medication to help with sleep. Melatonin was the most commonly reported medication taken for sleep, with 91% of parents reporting that it was “helpful” or “somewhat helpful” for their child with WS. Those who reported taking melatonin reported very few, if any, side effects.

Conclusion:
This parent-completed survey is a preliminary study showing the positive benefit of melatonin for individuals with WS who have disrupted sleep. The findings support the need for further study of the use of melatonin, in addition to behavioral sleep aids, given evidence that sleep disturbance negatively influences cognition and behavior.
Cognitive and Psychosocial Functioning of Preschool-Aged Children with Cancer
Authors: Willard Victoria W. , Cox Lauren E. , Russell Kathryn M. , Kenney Ansley , Jurbergs Niki , Molnar Andrew E. , Harman Jennifer L. 
Published: September 2017

ABSTRACT:

Objective:
Most children with cancer are diagnosed in early childhood, potentially resulting in missed developmental opportunities. The most common diagnoses—brain tumors, leukemia—are also associated with increased risk of neurocognitive deficits. Unfortunately, research regarding the functioning of preschool-aged children with cancer is limited. Our objective is to describe the cognitive and psychosocial functioning of preschool-aged children with cancer who completed a clinical evaluation at a hospital-based psychology clinic.

Methods:
Assessment data from 98 preschool-aged children with cancer (M = 5.17 years old, SD = 0.54; 54.1% male) who completed clinically referred evaluations from 2011 to 2015 were abstracted. Because of variability in assessment measures used across clinicians, indicators of cognitive, adaptive, preacademic, and emotional/behavioral functioning were collapsed before analyses.

Results:
Children were 2.56 years from diagnosis (SD = 1.46, range 0–5.25 years) and most were off therapy (79.6%). Primary diagnostic categories were represented: brain tumor (68.4%), solid tumor (15.3%), and leukemia (16.3%). Mean IQ scores were significantly below expectations (t[80] = −7.95, p < .001). There were no differences based on diagnostic category, treatment status, or sex. Adaptive functioning (t[73] = −8.42, p < .001) and preacademic skills (t[77] = −6.20, p < .001) were also significantly below expectations. Mean scores on a measure of parent-reported emotional/behavioral functioning were in the average range.

Conclusion:
Young children with cancer may be at significant risk of deficits in intellectual, adaptive, and preacademic functioning. Although our sample is biased by those who were referred for clinical evaluations, the severity of deficits highlights the potential vulnerability of young patients, even before most have entered formal school. Interventions—such as hospital-based preschool programs to increase preacademic skills—should be designed that explicitly target preschool-aged children and focus on a wide range of domains.