bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined treatment of atrophic scars using radiofrequency microneedling and hyaluronic acid fillers with subcision
Authors: Akopyan I. Kh. , Murakov S. V. , Gracheva S. G. , Bondarenko G. N. , Timofeyev A. V. , Vasilyev S. V. 
Published: September 2024

Introduction. Atrophic scars may be associated with significant psychological stress and a substantial negative impact on quality of life. Despite the great relevance of the atrophic scars therapy, existing treatment methods do not always provide their complete elimination.Aim. To study the efficacy of combined therapy of atrophic scars with radiofrequency microneedling (RF-MN), subcision and hyaluronic acid filler injection.Materials and methods. Ten female patients aged 28–44 years with a clinical diagnosis of atrophic scars were randomly assigned to two groups. Group 1 received RF-MN alone, while Group 2 received a combination treatment comprising RF-MN, subcision, and hyaluronic acid injections. Clinical effectiveness was assessed using the Goodman-Baron scar rating scale and the Global Aesthetic Improvement Scale (GAIS). Ultrasound was used to determine the changes in dermal thickness. The volume of depressions and skin texture were measured using the Antera 3D®. The safety of the treatment was evaluated by recording adverse events.Results. The combined method demonstrated superior efficacy compared to RF-MN alone in the majority of efficacy parameters. In Group 2, a statistically significant reduction in Goodman-Baron scale was observed in 100% of patients (p = 0.026). 3D measurements of the face demonstrated a more pronounced improvement in skin texture in Group 2 relative to Group 1. Statistically significant changes (p = 0.027) in the Face-Q scale were exclusively observed in the group that received the combined treatment. Ultrasonic imaging demonstrated a restoration of dermal thickness following treatment. No serious adverse events were observed. Expected local adverse events (pain, erythema, swelling, and bruising) were mild and resolved spontaneously within 1–7 days.Conclusion. The combined treatment with RF-MN followed by subcision and hyaluronic acid filler injections demonstrated its efficacy in patients with atrophic scars.
Design, Synthesis, and Docking of Novel Tropane Hybrids as Potent Hsp90 Inhibitors with Potential Anti-Breast Cancer Activity
Authors: Abbas Eman M. H. , Sabour Rehab , Alsaiari Norah A. , Medrasi Hanadi Y. , Kassem Asmaa F. , Farghaly Thoraya A. 
Published: September 2024

Background and Objective:
Breast cancer is the most common form of cancer
in women and is the leading cause of cancer-related deaths among women globally.
In this study, we aimed to synthesize a series of tropane derivatives to investigate their
Hsp90 inhibitory activity as well as their cytotoxic impact on breast cancer cells (MCF-
7 and MDA-MB-231).

Methods:
Novel fused-tropane derivatives were created and produced as inhibitors of
Hsp90, taking inspiration from XL888, a tropane medication used for treating cancer.
The target compounds were screened in vitro to determine their ability to inhibit the activity
of Hsp90.

Results:
All tropane derivatives displayed a good submicromolar inhibition of Hsp90
with IC50 values ranging from 52.64 to 76.05 nM, relative to XL888 reference medication
(IC50 = 27.78 nM). Among all the compounds examined, tropane derivative 5 exhibited
the highest level of Hsp90 inhibitory action, with an IC50 value of 52.64 nM. Furthermore,
the cytotoxic activity of all compounds was evaluated against two breast cancer
cell lines, namely MCF-7 and MDA-MB-231. Tropane derivative 5 exhibited greater
potency than doxorubicin against both cell lines. In addition, it demonstrated a safety
profile significantly superior to that of doxorubicin when tested on normal human cells
(WI-38 cells), thereby confirming its exceptional level of safety. The western blotting
analysis demonstrated a 2.4-fold reduction in Hsp90 expression in MCF-7 cells. Furthermore,
the molecular docking analysis has provided additional evidence for the capacity
of compound 5 to effectively bind with the target Hsp90 enzyme.

Conclusion:
We have succeeded in synthesizing novel tropane hybrids exhibiting significant
anti-Hsp90 action, similar to XL888 analogues.
A Comparison Between Microcapsules of Antioxidant Fraction of Stevia: an Evaluation of Physicochemical Parameters, Stability, Bioaccessibility,
and Antidiabetic Capacity
Authors: Marotti Siciliano Paulo Leonardo , Serra Cabeça Cynthia Letícia , Nogueira Natani Caroline , Campangolli Pereira Betanea , Kazue Enokida Milena , Trentin Zorzenon Maria Rosa , Souza Felipe de Oliveira , de Oliveira5 Adan Rodrigues , Pilau Eduardo Jorge , Godoi Silva Pauline , Matiucci Marcos Antonio , Dacome Antonio Sergio , da Costa Silvio Claudio , Milani Fernandes Paula Gimenez 
Published: September 2024

Introduction:
The antioxidant fraction of Stevia rebaudiana has important
antidiabetic potential, is poorly soluble, and has low stability, which makes its applicability
difficult.

Materials and Methods:
In this study, Stevia's fraction was obtained, characterized by
Ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLCMS/
MS), and microencapsulated with maltodextrin (MDF), gum arabic (GAF), whey protein
+ maltodextrin (MDWF), and whey protein + gum arabic (GAWF). Then, the following
parameters were evaluated: stability and antioxidant capacity over 30 days, physicochemical
characteristics, preservation of bioactive compounds by digestion, and in vitro antidiabetic
activity.

Results and Discussion:
The microcapsule with gum arabic showed better microencapsulation
efficiency, while its version with maltodextrin provided increased solubility. Microencapsulation
reduced the humidity and water activity in the microcapsules, except for the microcapsules containing
gum arabic. The combination of maltodextrin and whey protein showed greater luminosity
and a whiter powder. The microcapsules with maltodextrin and its mixture with gum arabic
kept the phenolic compounds stable for 30 days. The microencapsulation with whey protein increased
the antioxidant activity after 15 days of the process and during in vitro digestion. All
samples showed 96% inhibition of the α-glucosidase enzyme, and only the microcapsule with
maltodextrin inhibited α-amylase (58%).

Conclusion:
This study showed paramount results so that Antioxidant Stevia Fraction (ASF) can
effectively be an adjuvant product to prevent and treat diabetes.
OCORRÊNCIA DE ALTERAÇÕES RADIOGRÁFICAS NAS ARTICULAÇÕES DISTAIS EM EQUINOS DE TRABALHO
Authors: Lilyan da Silva Teixeira  , Raphael Bernado da Silva Neto  , Rafael Françoso  
Published: September 2024

As afecções do aparelho locomotor são comuns na clínica equina, variando desde alterações ortopédicas em animais jovens até doenças degenerativas em cavalos mais velhos, resultando em claudicação. Os membros anteriores são mais suscetíveis a maiores alterações porque suportam aproximadamente 60% do peso corporal. As técnicas de diagnóstico por imagem podem localizar as lesões e são essenciais para estabelecer tratamento e prognóstico garantindo qualidade de atendimento aos pacientes. Nesta pesquisa, foram avaliados radiograficamente as estruturas osteoarticulares das extremidades do membro torácico (articulações metacarpofalangiana e interfalangianas proximais e distais, sesamóides proximais e distais, falanges proximais, médias e distais) de 5 cavalos aposentados da cavalaria do 2° Esquadrão da Polícia Montada do município de Imperatriz- MA.
Propiedades psicométricas de la Escala de Bienestar Psicológico de Ryff en Argentina
Authors: García Matías Jonás , Del Valle Macarena Verónica , López Morales Hernán , Urquijo Sebastián 
Published: September 2024

Objetivo: probar la versión adaptada al español de la Escala de Bienestar Psicológico de Ryff en población argentina y analizar su consistencia interna y evidencias de validez basadas en la estructura interna y en la relación con otras variables. Método: se trabajó con dos grupos de participantes: uno de 3228 adultos argentinos (población general), con edades comprendidas entre los 20-83 años (M = 42.21; DE = 13.17). 81.9 % de género femenino. El otro grupo, de 153 estudiantes universitarios, edades entre 18-57 años (M = 26.71; DE = 7.53), 85 % de género femenino. Resultados: A través de un análisis factorial confirmatorio pudo observarse un buen ajuste del modelo de Ryff, con cargas factoriales apropiadas. La confiabilidad se analizó mediante fiabilidad compuesta. Los resultados indicaron una buena confiabilidad para todas las dimensiones. Se analizaron las correlaciones con variables teóricamente relacionadas: ansiedad, depresión y personalidad. Se observaron correlaciones estadísticamente significativas en las variables bajo análisis, en el sentido esperado. Conclusión: esta versión del instrumento mostró un ajuste muy bueno, buena confiabilidad y asociaciones descriptas previamente de las dimensiones con variables de ansiedad, depresión y personalidad. Se considera que esta versión es adecuada para ser utilizada en población argentina como herramienta para el estudio del bienestar psicológico desde el enfoque eudaimónico, tanto en el ámbito de la investigación como la clínica.
PENILAIAN KARBON TOTAL HUTAN PRODUKSI KOMODITAS PINUS BERBAGAI UMUR DI FORMASI GEOLOGI MERAWAN KAKI GUNUNG GUMITIR
Authors: Basuki Basuki , Mandala Marga 
Published: September 2024

Tahun 2100 diperkirakan terjadi kenaikan temperature sebesar 4,4oC. Karbon merupakan unsur yang menyumbang paling besar emisi gas rumah kaca (GRK) di atmosfer. Degradasi lahan berakibat penurunan sumber mata air, longsor, banjir, erosi, dan kandungan karbon baik di dalam tanah maupun di atas tanah. Tujuan penelitian yaitu mengkaji nilai karbon total di lahan hutan produksi pinus lereng Gunung Gumitir. Metode yang digunakan diskriptif eksploratif dengan pendekatan survai lapang. Data dianalisis dari kumpulan karbon di tegakan, akar, seresah dan tanah. Tiap sapling dilakukan pada lahan pinus dengan umur 2-37 tahun dan tiap sampling terbagi atas tiga ulangan dengan ukuran tiap ulangan 10m x 10 m. Berdasarkan hasil menunjukkan bahwa nilai karbon total dipengaruhi oleh umur tanaman pinus. Pinus dengan umur 37 tahun di lahannya memiliki jumlah karbon total sebesar 406,87 ton/ha, sedangkan yang berumur dua tahun jumlah karbon total sebesar 11,95 ton/ha, sehingga dapat dimodelkan dalam rumus linear Y= Jumlah karbon total dirumuskan Y=10,303x-35,671 dimana nilai Y merupakan jumlah karbon total, dan x merupakan umur tanaman pinus dengan koefisien determinasi (R2) model hubungan sebesar 0,9344.
Determination of the Biological Effectiveness of Fungicides to Protect Oak from Powdery Mildew
Authors: Гниненко Ю.И. , Перелётова Д.А. , Шакирова А.Д. 
Published: September 2024

Рассмотрены проблемы определения биологической эффективности фунгицидов для защиты всходов дуба от мучнистой росы. Эта болезнь часто встречается в лесных питомниках при выращивании посадочного материала, а также в естественных лесах. В арсенале средств защиты дуба в питомниках от мучнистой росы в настоящее время нет ни одного разрешённого пестицида. В связи с этим особую значимость получают испытания современных фунгицидов, предоставляющие возможность на легитимных условиях применять средства защиты. При проведении таких испытаний очень важно как можно более объективно оценить биологическую эффективность этих пестицидов. С этой целью предложено несколько формул для оценки защитного действия фунгицидов и проверена возможность их применения.
The article discusses the issues of determining the biological effectiveness of fungicides to protect oak seedlings from powdery mildew. This disease is of great importance in nurseries when growing planting material, as well as in natural forests. Currently, there is not a single approved pesticide in the arsenal of oak protection products in nurseries from powdery mildew. Therefore, it is important to test modern fungicides in order to be able to use protective equipment on legitimate terms. When conducting such tests, it is important to evaluate the effectiveness of these pesticides as objectively as possible. In order to evaluate the results as objectively as possible, the possibility of using some formulas for this has been tested. The comparisons made it possible to choose one of the formulas that most objectively assesses the effects of the fungicide.
Effects of selenomethionine on the growth, oxidative potential, digestive enzyme activity, and immune status of juvenile sterlet (Acipenser ruthenus)
Authors: Jarmołowicz Sylwia , Prusińska Maja , Wiszniewski Grzegorz , Schulz Patrycja , Kamaszewski Maciej , Szudrowicz Hubert , Wiechetek Wiktoria , Kawalski Kacper , Duda Arkadiusz , Sikorska Justyna , Kapusta Andrzej 
Published: September 2024

Abstract
In a 56-day experiment, the effects of selenium-enriched yeast (SeY) on the growth, enzymatic activity of the gastrointestinal tract, oxidative stress parameters, and selected immunological parameters of sterlet, Acipenser ruthenus (L.), were analyzed. The concentration of selenomethionine (SeMet) from SeY in the feed was 0 mg kg−1 (C), 0.7 mg kg−1 feed (S1), 1.4 mg kg−1 feed (S2), and 2.1 mg kg−1 feed (S3). Statistically significant differences were found in the final fish body weight between the control and groups S1 and S3. A significant increase in lipase activity was found in the initial section of the small intestine of fish from group S3. The highest activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase was recorded in the liver of fish from group S2. Analyses of non-specific humoral response parameters showed an increase in ceruloplasmin activity in group S1. The lowest active dose of SeMet derived from yeast tested in this study that stimulated humoral immunity and fish growth was 0.7 mg kg−1 feed (S1).
Spawning biology, breeding, and larval rearing techniques for Xenentodon cancila (Hamilton) for aquaculture and recreational use in Bangladesh: The first approach
Authors: Paul Shyamal Kumar , Sarker Bhakta Supratim , Sultana Nahid , Pall Jewel Chandra , Perven Tania , Saha Debasish , Majumdar Priyanka Rani 
Published: September 2024

Abstract
The study examined Xenentodon cancila (Hamilton) breeding biology, reproduction, and larval rearing. In this study, gonadosomatic index (GSI) and fecundity were measured for breeding biology every 15 days. Nine doses of common carp pituitary gland (CPG), human chorionic gonadotropin (HCG), and Ovaprim for breeding were administered, except in the control treatment that was without hormones. Mustard oil cake (D1), powdered feed (D2), and one-day-old live tilapia (Oreochromis sp.) larvae (D3) were used to determine larval survival after 28 days. From the end of May to mid-July, the mean GSI value exceeded 15 ± 0.72%, peaking at 16.02 ± 1.28% in June. Mean fecundity ranged from 110 ± 13.34 to 2961 ± 318.57, peaking at the end of June 2019, which indicated that this was the peak breeding season for X. cancila. The best spawning was with CPG at 20 mg kg−1 fish body weight (BW) and Ovaprim at 1.0 ml kg−1 BW, but the control group (B) and the group administered 500 IU kg-1 HCG (H1) did not spawn. Latency and hatching periods were 19-21 and 260-288 h, respectively. The highest fertilization, hatching, and survival rates were 92 ± 4.63%, 69 ± 5.52%, and 66 ± 4.11% with 20 mg kg−1 CPG (C2), while the next closest value was recorded with 1.0 ml kg−1 Ovaprim (O2). After 28 days, D3 had the highest survival rate (47.5 ± 4.62%), followed by D2 (31 ± 2.42%), and D1 (18 ± 1.54%). The findings will be useful for hatcheries, fish farmers, the ornamental fish sector, and biodiversity protection.
Exploring the meaning of care among lived experiences of patients with blindness: an interpretive phenomenological study†
Authors: Mohammadi Mohammad Ali , Heidarzadeh Mehdi , Mehri Saeed , Shamshiri Mahmood 
Published: September 2024

Abstract

Objective
To explore the meaning of care experienced by people with blindness in hospitals.

Methods
Interpretive phenomenology along with the 6-step method of van Manen was used to conduct the study. Using purposeful sampling, 15 people with legal blindness were interviewed. Thematic analysis was used to isolate the meaning of care.

Results
Five themes emerged: (a) nurses in the eyes of patients with blindness; (b) negligence in the caring moments; (c) being cared for in ambiguity; (d) Uncoordinated care; and (e) Psychological discomfort. These sub-themes were condensed into an overarching theme titled as “marginalized patients inside the stereotypical healthcare system.”

Conclusions
Lived experiences of patients with blindness revealed that hospitals provide stereotypic or inappropriate care for this minority group in society. Health professionals particularly nurses should be skilled to provide person-centered and coordinated care for patients with blindness.
Deep Machine Learning for Automatic Segmentation of the Pancreatic Parenchyma and its hypo- and hypervascular lesions on CT Images
Authors: Zamyatina K. A. , Zharikova A. V. , Kondratev E. V. , Ustalov A. A. , Staroverov N. E. , Nefedev N. A. , Gozheva A. R. , Shmeleva S. A. , Karmazanovsky G. G. 
Published: September 2024

Objective of the study. To develop and evaluate the effectiveness of a technology for segmenting the pancreatic parenchyma and its hyper- and hypovascular lesions on abdominal computed tomography (CT) scans using deep machine learning.Materials and methods. CT scans from the database of the A.V. Vishnevsky National Medical Research Center of Surgery were used for training and testing the algorithms – a total number of approximately 150 studies (arterial and venous phases). A test dataset of 46 anonymized CT scans (arterial and venous phases) was prepared for validation of the obtained algorithms, independently assessed by expert physicians. The primary segmentation neural network used is nn-UNet (M. Antonelli et al., 2022).Results. The average accuracy of the test dataset for the model determining segmentation masks of the pancreas on CT images had an AUC of 0.8 for the venous phase and 0.85 for the arterial phase. The segmentation masks of pancreatic formations had an AUC of 0.6.Conclusion. Automated segmentation of the pancreatic parenchyma structure using deep machine learning technologies demonstrated high accuracy. However, the segmentation of hypo- and hypervascular pancreatic lesions requires improvement. The overlap of the masks showed a rather low result, but in all cases, the location of the pathological formation was correctly identified by the algorithm. Enhancing the training dataset and the algorithm used could increase the accuracy of the algorithm.No false negative results were obtained when detecting pancreatic formations; in all cases, the INS detected “suspicious” areas of the pancreatic parenchyma. This can help reduce the omission of pancreatic pathologies in CT scans, and their further assessment can be carried out by the radiologist himself.
MRI-signs of structural and perfusion changes in chronic cerebral ischemia in liquidators of the aftermath of the Chernobyl nuclear power plant accident in the remote period
Authors: Kulikova T. A. , Meshkov N. A. , Solodkyi V. A. , Nudnov N. V. , Sergeev N. I. 
Published: September 2024

Cerebrovascular disease (CVD) was detected in 87% of the examined liquidators of accidents at the Chernobyl Nuclear Power Plant 7–8 years after participating in emergency recovery work with a radiation dose of ≤0.3 Gy. Analysis of the conducted studies shows that the results of structural methods of radiation diagnostics do not always correlate with the severity of the clinical picture. The use of an extended MRI examination of the brain to assess the correlation of anatomical and functional indicators of various observation groups in people with chronic cerebrovascular insufficiency seems promising.Purpose. To compare structural MRI data of the brain and indicators of cerebral hemodynamic perfusion in LPA and patients in the control group.Materials and methods: 147 patients aged from 55 to 87 years old with a diagnosis of chronic cerebrovascular disease were examined. The main group – 93 patients, the comparison group – 54 patients who were not exposed to radiation. The identified changes were assessed by the degree of atrophy of white and gray matter, by the degree of gliosis changes, and were compared with the data of perfusion parameters.Results. Signs of the atrophic process of the brain were detected in 93.9% of the main group and in 76.7% of patients from the comparison group, microangiopathy – in 100.0 and 83.4%. The risk of developing atrophy and microangiopathy in LPA is 1.24 (p = 0.041) and 1.14 (p = 0.008), respectively. When comparing MRI perfusion parameters (CBV, CBF and MTT) between the cortex and glia in patients of the main and control groups, it was found that the cortex/glia ratio between CBV and CBF in the OG is lower than in the GS by 13.9 and 24.2, respectively %. A comparative analysis of MRI perfusion parameters showed that in LPA the ratio between CBV in the glia and cortex of the right hemisphere is lower, by 0.3 and 11.7%, and in the left hemisphere – by 19.3 and 22.9%. CBF in the glia of the right hemisphere of the LPA is increased by 6.9%, and in the cortex it is decreased by 14.2%, in the left hemisphere – by respectively 9.8 and 13.4%.Conclusions. The study showed the high efficiency of contrast MRI perfusion and made it possible to identify the correlation of structural and perfusion changes in different research groups.
Data For a History of Behavior Analysis in Mato Grosso do Sul
Authors: Souza Felipe Maciel dos Santos , Borri Vanessa 
Published: September 2024

Purpose: The present article aimed to characterize the diffusion of Behavior Analysis in Mato Grosso do Sul.

Theoretical framework: The production of historical research in Behavior Analysis occurs througt diferente sources. One proposal for such a study is based on production in the area develped in different Brazilian states.

Method/design/approach: Based on the historiography methodology, using resources from bibliometrics and scientometrics with mixed analysis on the contribution of the collection Dialogues in Behavior Analysis, a publication by organizers of the Behavior Analysis’s event in Mato Grosso do Sul. For this purpose, the four volumes of the collection published between 2016 and 2024 were analyzed.

Results and discussion: The results show that 44 chapters were published, signed by 73 authors, affiliated with19 institutions, five of wich were from Mato Grosso do Sul, 13 from other states ando ne from Argentina. There were 15 authors who signed alone or co-authored 93% of the texts. Regarding the categroization of chapters, 52% were classified as conceptual texts, while only 11% were classified as basic research.

Research implications: The study provides data for a characterization of Behavior Analysis in Mato Grosso do Sul. From the data, it is possible to identify strengths and weaknesses and plan activities to consolidate the area.

Originality value: The collection proved to be very relevant for the dissemination of the area in the state, in addition to highlighting the scientific resistance of behavior analystis from Mato Grosso do Sul, who managed to maintain the production and launch of volumes even in the face of the pandemic scenario and difficulty faced by Brazilian science passed during the presidential term between 2019 and 2022.