bluuebunny/crossref_metadata_2025_split huggingface dataset:
NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma
Authors: Wang Xiangkun , Yang Chengkun , Liao Xiwen , Han Chuangye , Yu Tingdong , Huang Ketuan , Yu Long , Qin Wei , Zhu Guangzhi , Su Hao , Liu Xiaoguang , Ye Xinping , Chen Bin , Peng Minhao , Peng Tao 
Published: September 2017

AbstractNucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR)C and NLRX family proteins play a key role in the innate immune response. The relationship between these proteins and hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic significance of NLRC and NLRX family protein levels in HCC patients. Data from 360 HCC patients in The Cancer Genome Atlas database and 231 patients in the Gene Expression Omnibus database were analyzed. Kaplan–Meier analysis and a Cox regression model were used to determine median survival time (MST) and overall and recurrence‐free survival by calculating the hazard ratio (HR) and 95% confidence interval (CI). High NOD2 and low NLRX1 expression in tumor tissue was associated with short MST (P = 0.012 and 0.014, respectively). A joint‐effects analysis of NOD2 and NLRX1 combined revealed that groups III and IV had reduced risk of death from HCC as compared to group I (adjusted P = 0.001, adjusted HR = 0.31, 95% CI = 0.16–0.61 and adjusted P = 0.043, adjusted HR = 0.63, 95%CI = 0.41–0.99, respectively). NOD2 and NLRX1 expression levels are potential prognostic markers in HCC following hepatectomy.
Expression profiling of long noncoding RNA identifies lnc‐MMP3‐1 as a prognostic biomarker in external auditory canal squamous cell carcinoma
Authors: Liu Hong , Dai Chunfu , Wu Qianru , Liu Hongyan , Li Feitian 
Published: September 2017

AbstractOur previous studies suggested external auditory canal squamous cell carcinoma (EACSCC) is a rare malignancy with heterogeneous outcomes. This study aimed to identify lncRNA profile of EACSCC and determine the clinical application. Differential expression genes (DEGs) were investigated in EACSCC by whole transcriptome lncRNA arrays (GPL23178). RT‐PCR was used to quantify the microarray data. Bioinformatics analyses were performed to evaluate DEGs regulations in gene ontology and cellular pathways. Fluorescence in situ hybridization (FISH) was utilized to validate lncRNA expression. The overall survival was determined by Kaplan–Meier and log‐rank analyses. Our microarrays data had been submitted to Gene Expression Omnibus (GSE98912). We identified 5621 DEGs (3185 mRNAs, 2436 lncRNAs) in EACSCC. Lnc‐MMP3‐1 was the top one upregulated lncRNA in EACSCC with fold change of 237.2 (P < 0.001). RT‐PCR results showed similar expression levels as microarrays data. Bioinformatics analyses indicated development of EACSCC was involved in aberrant alternations of multiple biological processes and cellular pathways. FSIH assays also found lnc‐MMP3‐1 was significantly differentially overexpressed in EACSCC (P < 0.001). Tumor lnc‐MMP3‐1 levels were closely associated with differentiation degree (P = 0.016), tumor invasion (P = 0.015) and TNM stage (P = 0.015). Moreover, lnc‐MMP3‐1 expression was a significant prognostic factor in EACSCC (χ2 = 4.276, P = 0.039). The study is the first screening and analysis of lncRNAs profile in EACSCC and provides new insights into pathogenesis of this rare disease. Our findings offered convincing evidences that lnc‐MMP3‐1 is a novel survival predictor of EACSCC patients.
Spontaneous cholecystocolic fistula: an uncommon complication of chronic cholecystitis
Authors: Agrawal Vishakha , Joshi Utsav , Manandhar Sujan 
Published: September 2017

Key Clinical MessageCholecystocolic fistula, a rare complication of long‐standing gallstone disease, is a diagnostic challenge owing to nonspecific clinical presentation and lack of accurate preprocedural diagnostic modalities. In case of incidental discovery of the fistula during the surgical procedure, excision of the fistula with repair of the colonic defect is imperative.
Fusing Carborane Carboxylic Acids with Alkynes: 3D Analogues of Isocoumarins via Regioselective B−H Activation
Authors: Lin Furong , Shen Yunjun , Zhang Yuanbin , Sun Yuji , Liu Jiyong , Duttwyler Simon 
Published: September 2017

AbstractAn iridium‐catalyzed alkenylation/annulation sequence between monocarba‐closo‐dodecaborate carboxylic acids and diarylacetylenes is reported. Regioselective activation of the B2 position, followed by B−C bond formation and ring closure, affords 3D bora‐analogues of isocoumarins. The reaction tolerates a variety of functional groups on the aromatic rings and can be extended to B12‐substituted derivatives. Furthermore, subsequent alkenylation of the B4 vertex has been achieved in high yields.
Approximate Bayesian estimation in large coloured graphical Gaussian models
Authors: Li Qiong , Gao Xin , Massam Hélène 
Published: September 2017

AbstractDistributed estimation methods have recently been used to compute the maximum likelihood estimate of the precision matrix for large graphical Gaussian models. Our aim, in this article, is to give a Bayesian estimate of the precision matrix for large graphical Gaussian models with, additionally, symmetry constraints imposed by an underlying graph which is coloured. We take the sample posterior mean of the precision matrix as our estimate. We study its asymptotic behaviour under the regular asymptotic regime when the number of variablespis fixed and under the double asymptotic regime when bothpandngrow to infinity. We show in particular that when the number of parameters of the local models is uniformly bounded the standard convergence rate of our estimate of the precision matrix to its true value, in the Frobenius norm, compares well with the rates in the current literature for the maximum likelihood estimate.The Canadian Journal of Statistics46: 176–203; 2018 © 2017 Statistical Society of Canada
FFBAT: A security and cost‐aware workflow scheduling approach combining firefly and bat algorithms
Authors: Arunarani A. R. , Manjula D. , Sugumaran Vijayan 
Published: September 2017

SummaryCloud computing is distributed computing on a large scale driven by practical and effective operations, in which a pay‐per‐use framework provides dynamic scaling in response to the needs of workflow applications. Many existing cloud computing environments do not effectively employ security measures to counter security threats in task scheduling. To improve the scheduling system, we include security service to the scheduling process. However, adding security services to applications inevitably causes overhead in terms of computation time. The tradeoff between achieving high computing performance and providing the desired level of security protection imposes a big challenge for task scheduling. To solve this problem, we propose a security and cost aware scheduling algorithm for heterogeneous tasks in scientific workflow executed in a cloud. Our proposed algorithm is based on the hybrid optimization approach, which combines Firefly and Bat algorithms. The coding strategy is to minimize the total execution cost while meeting the deadline and risk rate constraints. The proposed system uses a multi‐objective function, and the results indicate that our algorithm always outperforms the traditional algorithms.
Financial early warning of non–life insurance company based on RBF neural network optimized by genetic algorithm
Authors: Yan Chun , Wang Lin , Liu Wei , Qi Man 
Published: September 2017

SummaryDue to the characteristic of risk diversification in non–life insurance industry, the company's financial risk early warning is very important. In order to reasonably predict the financial status of non–life insurance company, the evaluation system of financial risk indicator is constructed from the aspects of solvency, profitability, and growth ability. Taking data of non–life insurance companies in past years as sample, the evaluation indicators are weighted objectively using the entropy method. The RBF neural network model is improved with the genetic algorithm, and the early warning model is established. The empirical results show that the prediction accurate rate of RBF neural network model based on genetic algorithm is increased.
Low‐Polarization Lithium–Oxygen Battery Using [DEME][TFSI] Ionic Liquid Electrolyte
Authors: Ulissi Ulderico , Elia Giuseppe Antonio , Jeong Sangsik , Mueller Franziska , Reiter Jakub , Tsiouvaras Nikolaos , Sun Yang‐Kook , Scrosati Bruno , Passerini Stefano , Hassoun Jusef 
Published: September 2017

AbstractThe room‐temperature molten salt mixture of N,N‐diethyl‐N‐(2‐methoxyethyl)‐N‐methylammonium bis(trifluoromethanesulfonyl) imide ([DEME][TFSI]) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt is herein reported as electrolyte for application in Li–O2 batteries. The [DEME][TFSI]–LiTFSI solution is studied in terms of ionic conductivity, viscosity, electrochemical stability, and compatibility with lithium metal at 30 °C, 40 °C, and 60 °C. The electrolyte shows suitable properties for application in Li–O2 battery, allowing a reversible, low‐polarization discharge–charge performance with a capacity of about 13 Ah g
in the positive electrode and coulombic efficiency approaching 100 %. The reversibility of the oxygen reduction reaction (ORR)/oxygen evolution reaction (OER) is demonstrated by ex situ XRD and SEM studies. Furthermore, the study of the cycling behavior of the Li–O2 cell using the [DEME][TFSI]‐LiTFSI electrolyte at increasing temperatures (from 30 to 60 °C) evidences enhanced energy efficiency together with morphology changes of the deposited species at the working electrode. In addition, the use of carbon‐coated Zn0.9Fe0.1O (TMO‐C) lithium‐conversion anode in an ionic‐liquid‐based Li‐ion/oxygen configuration is preliminarily demonstrated.
Analysis of the Changes in Volatile Compound and Fatty Acid Profiles of Fish Oil in Chemical Refining Process
Authors: Song Gongshuai , Dai Zhiyuan , Shen Qing , Peng Xi , Zhang Mengna 
Published: September 2017

In this study, the effect of chemical refining on the volatile compound and fatty acid profiles of crude fish oil is evaluated. The process mainly comprises degumming, deacidification, decoloration, and deodorization. The changes in volatile compounds during the refining process are detected by headspace solid phase micro extraction (HS‐SPME) coupled with gas chromatography‐mass spectrometry (GC‐MS). Meanwhile, the fatty acid profile is determined by GC. The results showed that hexanal, nonanal, undecanal, 2‐nonanone, and 2‐undecanone are the key volatile components of fish oil, and the relative content of each compound changed significantly in each step. The proportion of polyunsaturated fatty acids (PUFAs) in the refined oil increased, while the proportion of saturated fatty acids (SFAs) reduced significantly. This study provides a theoretical basis for the improvement of sensory characteristics of fish oil via chemical refining.Practical Applications: Chemical refining is employed for improving the characteristics of crude fish oil, mainly including the volatile compound and fatty acid compositions. The result demonstrated that the refining process could affect the volatile compound and fatty acid profiles significantly, which provided the theoretical foundation for the optimization of process conditions.An NMR‐based metabolomic approach,using “one‐to‐one” OPLS‐DA models, allows to identify biomarkers of different production zones in “Bosana” Sardinian EVOO.
Recent contributions for improving sensitivity in chiral CE
Authors: Crego Antonio Luis , Mateos María , Nozal Leonor 
Published: September 2017

AbstractThe flexibility and versatility of the chiral CE are unrivaled and the same instrumentation can be used to separate a diverse range of analytes, both large and small molecules, whether charged or uncharged. However, one of the disadvantages is generally thought to be the poor sensitivity of ultraviolet (UV) detection, which is the most popular among CE detectors. This review focuses on methodologies and applications regarding improvements of sensitivity in chiral CE published in the last 2 years (June 2015 until May 2017). This contribution continues to update this series of biannual reviews, first published in Electrophoresis in 2006. The main body of the review brings a survey of publications organized according to different approaches to detect a low amount of analytes, either by sample treatment procedures or by in‐capillary sample preconcentration techniques, both using UV detection, or even by employing detection systems more sensitive than UV absorption, such as LIF or MS. This review provides comprehensive tables listing the new approaches in sensitive chiral CE with categorizing by the fundamental mechanism to enhance the sensitivity, which provide relevant information on the strategies employed. The concluding remarks in the final part of the review evaluate present state of art and the trends for sensitivity enhancement in chiral CE.
On‐line hybrid test method for evaluating the performance of structural details to failure
Authors: Skalomenos Konstantinos A. , Kurata Masahiro , Nakashima Masayoshi 
Published: September 2017

SummaryA test environment to evaluate the seismic performance of gusset plate connections intended for steel braced frames is proposed. The developed test method combines the substructuring techniques with finite element analysis methods in an on‐line hybrid scheme. Numerical substructure analysis is conducted on bracing members, while bracing connections are treated as experimental substructures. A force‐displacement combined control imposed with the aid of 2 jacks ensures physical continuity between the analysis and test. The rotational behavior of gusset plate connections subjected to large inelasticity and varying axial loading until fracture is investigated. Two gusset plate details were designed and tested to verify the efficiency of the proposed method. The test method is rational, and smooth operation is achieved. The test results revealed the advantage of the developed on‐line hybrid test method in exploring the ultimate capacity of bracing connections.
Second primary cancer after major salivary gland carcinoma
Authors: Hirvonen Karoliina , Rantanen Matti , Haapaniemi Aaro , Pitkäniemi Janne , Malila Nea , Mäkitie Antti A. 
Published: September 2017

AbstractBackgroundWe investigated the risk of second primary cancers after major salivary gland carcinoma in Finland, with a population of 5.5 million.MethodsNationwide cancer registry data were used to identify patients with major salivary gland carcinoma diagnosed between 1953 and 2014. Standardized incidence ratios (SIRs) were estimated to compare their second primary cancer risk with the respective site‐specific cancer risk in the general population.ResultsThere were 1727 patients with major salivary gland carcinomas and 222 second primary cancers had been diagnosed in these patients (SIR 1.43). The risk was increased for cancers of the thyroid (SIR 5.12), breast (SIR 1.63), respiratory organs (SIR 1.63), male genital organs (SIR 1.48), melanoma of the skin (SIR 3.35), and nonmelanoma skin cancer (SIR 2.50). The risk was high during the first 5 years and after 20 years of diagnosis.ConclusionSecond primary cancers can occur among patients with major salivary gland carcinoma even after a long time period. This needs to be recognized in the follow‐up of these patients.
Multi‐agent technologies in economics
Authors: Bajo Javier , Mathieu Philippe , Escalona María José 
Published: September 2017

SummaryThis paper summarizes some of the trends in the use of multi‐agent technologies in economics. Multiple agent systems, fuzzy sets and neural networks are critical tools used to investigate the emerging economics research agenda related to data mining, dynamic markets stock selection and bank stress testing. This paper reviews the contributions of four such examples.
Gellan gum‐hydroxyapatite composite spongy‐like hydrogels for bone tissue engineering
Authors: Manda Marianthi G. , da Silva Lucilia P. , Cerqueira Mariana T. , Pereira Diana R. , Oliveira Mariana B. , Mano João F. , Marques Alexandra P. , Oliveira Joaquim M. , Correlo Vitor M. , Reis Rui L. 
Published: September 2017

AbstractOsteoinductive biomaterials represent a promising approach to advance bone grafting. Despite promising, the combination of sustained biodegradability, mechanical strength, and biocompatibility in a unique biomaterial that can also support cell performance and bone formationin vivois demanding. Herein, we developed gellan gum (GG)–hydroxyapatite (HAp) spongy‐like hydrogels to mimic the organic (GG) and inorganic (HAp) phases of the bone. HAp was successfully introduced within the GG polymeric networks, as determined by FTIR and XRD, without compromising the thermostability of the biomaterials, as showed by TGA. The developed biomaterials showed sustained degradation, high swelling, pore sizes between 200 and 300 μm, high porosity (>90%) and interconnectivity (<60%) that was inversely proportional to the total polymeric amount and to CaCl2crosslinker. CaCl2and HAp reinforced the mechanical properties of the biomaterials from a storage modulus of 40 KPa to 70–80 KPa. This study also showed that HAp and CaCl2favored the bioactivity and that cells were able to adhere and spread within the biomaterials up to 21 days of culture. Overall, the possibility to tailor spongy‐like hydrogels properties by including calcium as a crosslinker and by varying the amount of HAp will further contribute to understand how these features influence bone cells performancein vitroand bone formationin vivo. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 479–490, 2018.
Synthesis of Novel Substituted Phenyl‐3‐Hydrazinyl‐Quinoxaline‐2‐Amine Derivatives: Evaluation of Antimicrobial Activity and Its Molecular Docking Studies
Authors: Paliwal Sarvesh , Sharma Swapnil , Dwivedi Jaya , Mishra Achal 
Published: September 2017

New series of quinoxaline derivatives (4a–4h) were synthesized by treating 2‐chloro‐3‐hydrazinyl quinoxalin (3) with various anilines. Compound 3 was obtained from the 2,3‐dichloroquinoxaline 2 which was prepared from 4‐dihydroquinoxaline‐2,3‐dione (1). All synthesized compounds (4a–4h) were characterized by various spectral techniques, that is, IR, 1H‐NMR, mass spectroscopy, and elemental analysis and completion of reaction were confirmed by TLC. In vitro antimicrobial activity of synthesized compounds was evaluated using disc diffusion assay against gram‐positive and gram‐negative microbial strains, and then, the minimum inhibitory concentration and IC50 values of compounds were also determined. The results of antimicrobial study revealed that compounds 4e, 4g, and 4a were active and exhibited better inhibitory activities as compared with standard drug amoxicillin. Docking studies were performed by using Argus lab, and all the compounds exhibited good docking scores between −9.53 and −7.94 kcal/mol against dihydrofolate reductase protein fragment from Staphylococcus aureus (PDB ID‐4XE6). Among all compounds, 4e has shown the maximum docking score and found in agreement to in vitro studies.
Dispersive admicelle solid‐phase extraction based on sodium dodecyl sulfate coated Fe3O4 nanoparticles for the selective adsorption of three alkaloids in Gegen‐Qinlian oral liquid before high‐performance liquid chromatography
Authors: Shi Zhihong , Xu Dan , Zhao Xuan , Li Xinghong , Shen Huimin , Yang Bing , Zhang Hongyi 
Published: September 2017

AbstractA novel dispersive admicelle solid‐phase extraction method based on sodium dodecyl sulfate‐coated Fe3O4 nanoparticles was developed for the selective adsorption of berberine, coptisine, and palmatine in Gegen‐Qinlian oral liquid before high‐performance liquid chromatography. Fe3O4 nanoparticles were synthesized by a chemical coprecipitation method and characterized by using transmission electron microscopy. Under acidic conditions, the surface of Fe3O4 nanoparticles was coated with sodium dodecyl sulfate to form a nano‐sized admicelle magnetic sorbent. Owing to electrostatic interaction, the alkaloids were adsorbed onto the oppositely charged admicelle magnetic nanoparticles. The quick separation of the analyte‐adsorbed nanoparticles from the sample solution was performed by using Nd‐Fe‐B magnet. Best extraction efficiency was achieved under the following conditions: 800 μL Fe3O4 nanoparticles suspension (20 mg/mL), 150 μL sodium dodecyl sulfate solution (10 mg/mL), pH 2, and vortexing time 2 min for the extraction of alkaloids from 10 mL of diluted sample. Four hundred microliters of methanol was used to desorb the alkaloids by vortexing for 1 min. Satisfactory extraction recoveries were obtained in the range of 85.9–120.3%, relative standard deviations for intra‐ and interday precisions were less than 6.3 and 10.0%, respectively. Finally, the established method was successfully applied to analyze the alkaloids in two batches of Gegen‐Qinlian oral liquids.
Ultrastretchable, Tough, and Notch‐Insensitive Hydrogels Formed with Spherical Polymer Brush Crosslinker
Authors: Zhang Rui , Wang Lei , Shen Zheqi , Li Min , Guo Xuhong , Yao Yuan 
Published: September 2017

AbstractSpherical polymer brushes, poly(acrylic acid) (PAA)‐grafted polystyrene nanoparticle (PAA@PS), are employed as the macro‐crosslinker to prepare PAA hydrogels. Benefitting from the innumerable hydrogen bonds between highly entangled PAA chains both in bulk and on the polymer brush, the PAA/PAA@PS hydrogels combine desirable stretchability, toughness, and notch‐insensitivity. The uniaxial tensile tests show a very high fracture elongation up to 9.1 × 103% while the fracture toughness reaches 3.0 MJ m−3 and the maximum swelling ratio of the hydrogel can be 2.0 × 103 as well. After being loaded with silver nanoparticles, the PAA/PAA@PS hydrogels are employed as a recyclable catalyst successfully.
Physiological Gut Oxygenation Alters GLP‐1 Secretion from the Enteroendocrine Cell Line STC‐1
Authors: Kondrashina Alina , Papkovsky Dmitri , Giblin Linda 
Published: September 2017

ScopeEnteroendocrine cell lines are routinely assayed in simple buffers at ≈20% oxygen to screen foods for bioactives that boost satiety hormone levels. However, in vivo, enteroendocrine cells are exposed to different phases of food digestion and function at low oxygen concentration, ranging from 7.5% in the stomach to 0.5% in the colon–rectal junction.Methods and resultsThe objective of this study is to investigate the effect of physiologically relevant O2 concentrations of the gut on the production and secretion of the satiety hormone, glucagon‐like peptide 1 (GLP‐1), from the murine enteroendocrine cell line, secretin tumor cell line (STC‐1), in response to dairy macronutrients as they transit the gut. GLP‐1 exocytosis from STC‐1 cells is influenced by both oxygen concentration and by individual macronutrients. At low oxygen, STC‐1 cell viability is significantly improved for all macronutrient stimulations and cyclic adenosine monophosphate levels are dampened. GLP‐1 secretion from STC‐1 cells is influenced by both the phase of yogurt digestion and corresponding O2 concentration. Atmospheric oxygen at 4.5% combined with upper gastric digesta, which simulates ileum conditions, yields the highest GLP‐1 response.ConclusionThis demonstrates the importance of considering physiological oxygen levels and food digestion along gastrointestinal tract for reliable in vitro analysis of gut hormone secretion.