bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of stimulus dose on neuropsychological functioning after electroconvulsive therapy in patients with major depressive disorder
Authors: Rummel Lea , Göke Katharina , Philipsen Alexandra , Hurlemann René , Kiebs Maximilian 
Published: September 2024

IntroductionElectroconvulsive therapy (ECT) is the most effective treatment for patients suffering from treatment-resistant depression but its use is often limited by the concern for cognitive side effects. This study examines the effect of ECT on autobiographical and verbal memory compared to a healthy control group and the impact of the mean stimulus dose on cognition after ECT.MethodsAutobiographical and verbal memory were assessed in depressed patients and healthy controls before the first and within one week after the last ECT treatment. Neuropsychological testing included the Autobiographical Memory Interview, the Verbal Learning and Memory Test and five tests from the Cambridge Neuropsychological Test Automated Battery. The mean charge delivered across the ECT series and the total number of sessions were examined in relationship to cognitive impairment after ECT using a multiple regression model.ResultsAutobiographical memory was significantly impaired after ECT treatment compared to healthy controls. Baseline scores were lower for depressed patients on all cognitive domains. Improvements in performance after ECT were found on tests for executive functions and working memory. Effects of the mean charge delivered on cognitive functioning after ECT were heterogeneous across cognitive domains but significant for verbal retrograde memory.ConclusionECT led to autobiographical memory impairment. The relationship between mean charge delivered and cognitive performance is heterogeneous across different cognitive domains and requires further research. Significant effects of the mean charge delivered were found without a significant difference in cognitive functioning compared to a healthy control group.
Impact of informal social support on the mental health of older adults
Authors: Dong Yi , Cheng Lanyan , Cao Hailin 
Published: September 2024

ObjectiveThe role of informal social support in fostering active aging within the context of the “silver wave” is significant. This study investigated how such support influenced the mental health of older adults, with the goal of affirming its indispensable contribution to enhancing their psychological well-being.MethodsEmploying Principal Component Analysis (PCA) to construct the informal social support variable, this study rigorously analyzed the effects and underlying mechanisms of informal social support on mental health in older adults, utilizing data from the 2018 China Longitudinal Aging Social Survey (CLASS).ResultsInformal social support exerted a substantial positive influence on the mental health of older adults, particularly among younger, non-agricultural older adult populations who preferred cohabitation with their children. This form of support significantly enhanced mental well-being by elevating life satisfaction, improving access to medical services, and fostering active social engagement.ConclusionThis study elucidates the role of informal social support in bolstering the mental health of older adults. Future efforts should focus on fostering a supportive environment that enhances older adult care experiences, reforming the healthcare system to better meet the needs of the aging population, and promoting avenues for social engagement, thereby achieving a balanced integration of their emotional and physical care.
Effects of heat stress on oxidative balance and sperm quality in dogs
Authors: Burgio Matteo , Forte Lucrezia , Prete Andrea , Maggiolino Aristide , De Palo Pasquale , Aiudi Giulio Guido , Rizzo Annalisa , Carbonari Alice , Lacalandra Giovanni Michele , Cicirelli Vincenzo 
Published: September 2024

IntroductionHeat stress negatively affects both animal reproductive performance and their overall wellbeing and welfare. When temperatures soar, the body responds to maintain balance, resulting in heat stress. This triggers various responses, including the buildup of reactive oxygen species (ROS), which can harm sperm vitality through lipid peroxidation. Oxidative damage can result in sperm dysfunction. This study aimed to evaluate the effects of environmental heat stress on canine quantitative and qualitative ejaculate parameters.MethodsThirty-six male crossbred dogs were involved in the trial. This study was performed in 2022, precisely from May to August. Dogs were subdivided in two groups, one heat stressed (HS) and one in thermoneutrality (TN). Thermo Hygrometric Index (THI) was hourly measured and ranged from 60 to 71 in TN dogs and from 60 to 83 for HS dogs. Semen and blood samples were collected at 30-day intervals, starting from May (0 days), and then at 30 days, 60 days, and 90 days and analysis for evaluating biochemical profile, semen oxidative status, and semen quality were performed.ResultsIn HS dogs, serum total protein, albumin, and urea concentrations showed a significant decrease after 60 days (P &lt; 0.01), with values lower than those observed in TN dogs (P &lt; 0.01). Both catalase and glutathione peroxidase concentrations were reduced after 60 days in HS dogs, showing lower levels than the TN group (P &lt; 0.01 and P &lt; 0.05, respectively). Antioxidant potential increased over time in HS dogs, reaching higher values at 60 days (P &lt; 0.05) and 90 days (P &lt; 0.01). On the other hand, ROS in the sperm of HS animals rose by day 90, surpassing the values recorded at previous time points and in TN dogs (P &lt; 0.01). Semen concentration (P &gt; 0.01) and total sperm count (P &lt; 0.05) declined after 30 days in the HS group and remained lower than the TN group throughout the trial.DiscussionThe study demonstrates that heat stress negatively affects the oxidative status and sperm quality of male dogs, reducing reproductive performance. However, further research is needed due to the lack of complete breed homogeneity in the study groups.
Protective Role of Sulforaphane against Physiological Toxicity of Triphenyltin in Common Carp (Cyprinus carpio haematopterus)
Authors: Wang Bingke , Zhang Chunnuan , Ma Jianshuang , Wang Yanhui , Zhang Ling , Yang Xingli , Jia Tao , Zhang Kaisong , Zhang Qin 
Published: September 2024

This experiment mainly explored the protective role of sulforaphane (SFN) against physiological toxicity of triphenyltin (TPT) in Cyprinus carpio haematopterus. In total, 320 Fish (56.90 ± 0.40 g) were randomly divided into four groups with four replicates each. The control group was fed the basal diet, the TPT group (TPT) was exposed to 10 ng L−1 TPT on the basis of the control group, the SFN + TPT group (TPT + SFN) was fed a diet supplemented with 10 mg kg−1 SFN on the TPT group, and the SFN group (SFN) was fed a diet supplemented with 10 mg kg−1 SFN. After 56 days of breeding trials, the results showed that TPT exposure resulted in a remarkable decrease (p < 0.05) in final weight, weight gain rate (WGR), specific growth rate (SGR), and condition factor (CF), but an increase (p < 0.05) in feed conversion ratio (FCR) and hepatosomatic index (HSI) of fish. TPT treatment decreased (p < 0.05) the amounts of hematocrit (Hct) and hemoglobin (Hb), plasma complement component 3 (C3) and C4 contents, alternative complement pathway (ACH50), acid phosphatase (ACP) and lysozyme (LZM) activities, liver glutathione (GSH) content, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) activities, interleukin 10 (IL-10), and SOD mRNA expressions, but increased (p < 0.05) plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, liver malonaldehyde (MDA) content, tumor Cyclooxygenase 2 (COX2), and necrosis factor α (TNFα), IL-1β, and MDA mRNA expressions. A histological analysis of the liver showed that a higher occurrence rates of the hepatocyte hypertrophy, nuclear disappearance and hepatocyte vacuolization was observed in the hepatocytes of fish exposed to TPT, and it was accompanied by the dilation of hepatic sinusoids. In addition, the toxicity induced by TPT was significantly improved in the groups that were treated with SFN, and SFN was able to improve growth performance and immunity, alleviate TPT-induced changes in inflammatory factors, ameliorate oxidative stress, and increase the activity of antioxidant enzymes (p < 0.05). The addition of SFN also alleviated liver damage caused by TPT and protected the structural integrity of the liver. Overall, these findings suggest that TPT inhibited the growth, immunity, and antioxidant capacity of Cyprinus carpio haematopteru. Dietary SFN could be beneficial for growth promotion, immunity, antioxidant capacity, and protection of liver structural integrity. Therefore, SFN is a prospective feed supplement for ameliorating the damage caused to fish by TPT contamination.
Analisis Jumlah Kecelakaan Lalu Lintas, Korban, dan kerugian di Provinsi Lampung Tahun 2021 Dengan Metode K-Means Cluster
Authors: Rivai Muklas , Hutabarat Aulia Khairani , Halawa Doni Hardian , Satrio Ilham , Tarmizi Muhammad Syauki , Frasiska Nadia , Pratiwi Niken , Alma Zalikha 
Published: September 2024

Abstract: Provinsi Lampung is facing a serious challenge regarding the high rate of traffic accidents, triggered by the increasing number of vehicles and inadequate infrastructure. Low awareness of traffic regulations also serves as a major cause of accidents. This research employs the Cluster Analysis method within the Geographic Information System (GIS) to categorize traffic accident data in Lampung Province for the year 2021. The data encompasses the number of accidents, fatalities, serious injuries, minor injuries, and financial losses across 14 districts/cities. The cluster analysis results identify two main groups with distinct characteristics. The first cluster exhibits a low accident rate, while the second cluster shows a high accident rate, contributing significantly to the total number of accidents, fatalities, serious injuries, minor injuries, and financial losses. Recommendations for interventions are tailored to the characteristics of each cluster, emphasizing either fatal injury prevention or road infrastructure improvements. The findings of this research provide a foundation for designing more effective strategies to reduce accident risks and enhance traffic safety in Lampung Province
Keywords: K-means, Accidents, Lampung Province
Development of women’s volunteerism in the performance of works in the interests of EMERCOM of Russia
Authors: Peregudova N. V. , Kondashov A. A. , Matorina O. S. 
Published: September 2024

This article investigates the issues of men’s and women’s participation in the sphere of volunteerism, as well as their motivation and expectations from the activities in this sphere. The importance of joint efforts of state and volunteer organizations for effective response to emergency situations is shown. The authors consider the aspects of professional training of volunteers, social support, development of technological infrastructure that helps volunteers in solving their tasks. Special attention is paid to the motivation of volunteers and the influence of stereotypes on the choice of profession. The role of women volunteers is also highlighted, examples of successful volunteerism in Russia, including rescue operations and humanitarian aid in times of crisis are given.
Internet-communications of student youth: Aspects of network identity construction (on the example of freshmen students of St. Petersburg University of Management Technologies and Economics)
Authors: Shebolkina E. P. , Krasikova N. V. 
Published: September 2024

The article presents the results of the study of some aspects of Internet communications and the constructed network identity of university freshmen as representatives of generation Z, or “digital youth”. The results of the study have shown that the majority of respondents do not make a big distinction between real and virtual self-presentation, try to adhere to socially approved images, act in the Web to a greater extent as a consumer of content than as a creator. It was also found that the majority of the study participants pay attention to changes in the construction of their online identity over the past two years, and attribute this process to personal maturation and awareness of the dangers of the Internet. In the future, according to the authors, it seems interesting to focus further research in the field of regulatory mechanisms of behavior of digital youth on the Internet.
Analisis Berbagai Faktor yang Mempengaruhi Aksesibilitas BPJS Kesehatan dengan Aplikasi Mobile JKN
Authors: Shaliva Sulistiyo Azka 
Published: September 2024

This study employs the Rasch Model to analyze factors influencing the accessibility of the BPJS Health Insurance mobile application (JKN) in Indonesia. A survey was conducted among BPJS Health participants from various regions to evaluate the availability of technological infrastructure, digital literacy levels, and perceptions of government policy support. The analysis reveals that adequate technological infrastructure and high levels of digital literacy significantly impact the accessibility of the JKN application. Strong policy support also plays a crucial role in enhancing adoption and accessibility of the application. Recommendations for improvement include enhancing technological infrastructure in remote areas, increasing digital literacy through training programs, and formulating policies that support the use of technology for more inclusive and effective healthcare services nationwide. This research contributes significantly to understanding the key factors that need to be addressed in the development of technology-based healthcare applications in Indonesia.

ABSTRAK

Penelitian ini menggunakan Rasch Model untuk menganalisis faktor-faktor yang mempengaruhi aksesibilitas aplikasi mobile JKN BPJS Kesehatan di Indonesia. Survei dilakukan terhadap peserta BPJS Kesehatan di Kota Bandung untuk mengevaluasi ketersediaan infrastruktur teknologi, literasi digital, dan persepsi terhadap dukungan kebijakan pemerintah. Hasil analisis menunjukkan bahwa ketersediaan infrastruktur teknologi yang memadai dan tingkat literasi digital yang baik secara signifikan mempengaruhi kemudahan akses terhadap aplikasi JKN. Dukungan kebijakan yang kuat juga berperan penting dalam meningkatkan adopsi dan aksesibilitas aplikasi ini. Rekomendasi untuk perbaikan termasuk peningkatan infrastruktur teknologi di daerah terpencil, peningkatan literasi digital melalui program pelatihan, serta perumusan kebijakan yang mendukung pemanfaatan teknologi untuk layanan kesehatan yang lebih inklusif dan efektif di seluruh Indonesia. Penelitian ini memberikan kontribusi penting dalam pemahaman faktor-faktor kunci yang perlu diperhatikan dalam pengembangan aplikasi kesehatan berbasis teknologi di Indonesia.
Evaluasi Pengaruh Implementasi Smart City terhadap Kesejahteraan Warga
Authors: Bening Setiadi Nestiany 
Published: September 2024

This research explores the impact of perceptions of smart city development on the stress and comfort levels of urban residents. This research aims to understand how smart technologies in public administration, services, infrastructure, and environmental protection affect individuals' perceptions of their city environment. The quantitative approach method used the Rasch Model to analyse data obtained from 100 respondents in West Java through an online questionnaire. The results showed that residents tend to assess smart city development based on the relevance of technology to their personal lives and their ability to cope with the changes faced. Positive perceptions of smart technology in public administration tend to increase comfort, while negative perceptions can increase stress levels, especially related to privacy and self-control. In conclusion, while smart city development has the potential to improve quality of life, careful management of the psychological and social impacts of smart technologies is needed to minimise potential negative effects on city residents.

ABSTRAK

Penelitian ini mengeksplorasi dampak persepsi terhadap pembangunan kota pintar terhadap tingkat stres dan kenyamanan penduduk perkotaan. Penelitian ini bertujuan adalah untuk memahami bagaimana teknologi cerdas dalam administrasi publik, layanan, infrastruktur, dan perlindungan lingkungan mempengaruhi persepsi individu terhadap lingkungan kota mereka. Metode pendekatan kuantitatif dengan menggunakan Rasch Model untuk menganalisis data yang diperoleh dari 100 responden di Jawa Barat melalui kuesioner online. Hasil penelitian menunjukkan bahwa penduduk cenderung menilai pembangunan kota pintar berdasarkan relevansi teknologi terhadap kehidupan pribadi mereka dan kemampuan mereka untuk mengatasi perubahan yang dihadapi. Persepsi positif terhadap teknologi cerdas dalam administrasi publik cenderung meningkatkan kenyamanan, sementara persepsi negatif dapat meningkatkan tingkat stres, terutama terkait dengan privasi dan kontrol diri. Kesimpulannya, walaupun pembangunan kota pintar memiliki potensi untuk meningkatkan kualitas hidup, manajemen yang hati-hati terhadap dampak psikologis dan sosial dari teknologi cerdas diperlukan untuk meminimalkan potensi efek negatif terhadap penduduk kota.
Analisis Penelitian mengenai Kualitas Pelayanan Publik Pemerintah Kota Bandung
Authors: Bhatara Hogan 
Published: September 2024

This research aims to explain the importance of improving public service systems in line with the increasing demands of society. In this context, the public sector and public systems face complex challenges, especially in dealing with high levels of uncertainty often referred to as "wicked problems". To overcome these challenges, collaboration involving various perspectives is needed to find effective solutions. The research method used is qualitative research, which involves in-depth interviews with relevant stakeholders, participatory observation, and document analysis. This research provides an in-depth understanding of the complexity of the public service system and the importance of collaboration in facing the challenges. The results of this research can provide valuable insights for decision-makers in designing better strategies and policies in improving public services.

ABSTRAK

Penelitian ini bertujuan untuk menjelaskan pentingnya peningkatan sistem pelayanan publik seiring dengan meningkatnya tuntutan masyarakat. Dalam konteks ini, sektor publik dan sistem publik menghadapi tantangan yang kompleks, terutama dalam menghadapi tingkat ketidakpastian yang tinggi yang sering disebut sebagai "masalah jahat". Untuk mengatasi tantangan ini, diperlukan kolaborasi yang melibatkan berbagai perspektif untuk menemukan solusi yang efektif. Metode penelitian yang digunakan adalah penelitian kualitatif, yang melibatkan wawancara mendalam dengan pemangku kepentingan terkait, observasi partisipatif, dan analisis dokumen. Penelitian ini memberikan pemahaman yang mendalam tentang kompleksitas sistem pelayanan publik dan pentingnya kolaborasi dalam menghadapi tantangan yang ada. Hasil penelitian ini dapat memberikan wawasan yang berharga bagi pengambil keputusan dalam merancang strategi dan kebijakan yang lebih baik dalam meningkatkan pelayanan publik.
DESAIN SENYAWA DERIVAT HALOFUGINON TERHADAP ENZIM PROLIL-tRNA SINTETASE Plasmodium falciparum SECARA IN SILICO
Authors: Tegar Achsendo Yuniarta , Fransisco Candra Gonsalez , Arif Maulana Azis , Dini Kesuma 
Published: September 2024

Malaria adalah salah satu penyakit infeksi yang memiliki tingkat kematian cukup tinggi. Penyakit ini disebabkan oleh parasit Plasmodium yang ditularkan melalui gigitan nyamuk Anopheles betina. Sejak tahun 2004 obat pilihan utama untuk malaria adalah obat kombinasi artemisinin (ACT). Salah satu obat yang dapat dikembangkan sebagai calon obat antimalaria saat ini yaitu halofuginon dan turunannya. Halofuginon bekerja dengan metode inhibisi enzim prolil-tRNA sintetase pada Plasmodium falciparum (PfPRS). Penelitian ini bertujuan untuk mengoptimasi struktur senyawa halofuginon untuk mendapatkan senyawa baru yang poten dan tidak toksik. Tahapan modifikasi senyawa dilakukan dengan bantuan webserver ADMETopt untuk memperoleh beberapa rekomendasi senyawa derivat. Senyawa turunan ini kemudian disikrining menggunakan webserver SwissADME dengan melihat parameter absorbsi serta deteksi gugus fungsi PAINS dan toksikofor. Senyawa yang memenuhi kriteria dilakukan molecular docking untuk mendapatkan nilai binding energy dan untuk mengetahui interaksi ikatannya dengan residu asam amino enzim PRS. Hasil penelitian ini diperoleh 2 senyawa: 8‐[3‐(7‐bromo‐6‐kloro‐4‐okso‐3,4‐dihidrokuinazolin‐3‐il)‐2‐oksopropil]‐7‐hidroksi‐3,4‐dihidro‐2H‐1,3‐benzoksazin‐2,4‐dion dan 3‐(3‐{2‐amino‐5‐okso‐5H,6H‐imidazo[4,5‐d]azepin‐4‐il}‐2‐oksopropil)‐7‐bromo‐6‐kloro‐3,4‐dihidrokuinazolin‐4‐on. Kedua senyawa ini memiliki nilai energi interaksi sebesar -10,79 kkal/mol dan -10,19 kkal/mol yang mendekati nilai dari halofuginon sebesar -10,98 kkal/mol. Selanjutnya perlu dilakukan verifikasi dengan melakukan uji in vitro terhadap enzim PRS dan parasit Plasmodium falciparum, serta uji toksisitas agar didapat turunan febrifugin yang poten dan non-toksik.
STUDI ETNOMEDISIN TUMBUHAN OBAT ANTIPIRETIK DAN ANTIGASTRITIS PADA MASYARAKAT DESA SIRNABAYA KECAMATAN RAJADESA KABUPATEN CIAMIS
Authors: Hendy Suhendy , Vina Alvionita , Ira Rahmiyani 
Published: September 2024

Etnomedisin adalah pengetahuan kesehatan dari sudut pandang masyarakat lokal paa suatu etnis tertentu. Masyarakat Desa Sirnabaya Kecamatan Rajadesa Kabupaten Ciamis masih memanfaatkan pengobatan tradisional (Batra) untuk kasus demam dan gastritis e. Praktik pengobatannya selain dilakukan oleh Batra (praktik pengobatan tradisional) di desa tersebut, dilakukan juga secara mandiri oleh masyarakat. Tujuan dari penelitian ini adalah untuk memberikan wawasan tentang penggunaan obat-obatan sebagai pengobatan antipiretik dan antigastritis yang dapat dimanfaatkan oleh masyarakat Desa Sirnabaya. Jenis penelitian menggunakan desain kualitatif metode deskriptif dengan teknik Purposive dan Snowball sampling. Hasil penelitian menunjukkan nilai frekuensi tertinggi sitasi kasus antipiretik adalah daun dadap serep 50,94%, famili fabaceae 53,92%, bagian daun 76,69%, cara pengolahan ditumbuk 64,49%, dan cara penyajian dibalurkan 58,80%. Sedangkan pada kasus gastritis adalah kunyit 62,33%, famili zingiberaceae 91,86%, bagian rimpang 73,71%, cara pengolahan direbus 41,46%, dan cara penyajian diminum 99,45%. Sedangkan nilai RKI (Rasio Kesepakatan Informan) tertinggi pada kasus antipiretik yaitu influenza sebesar 0,90 dan kasus antigastritis yaitu anoreksia sebesar 0,88.