bluuebunny/crossref_metadata_2025_split huggingface dataset:
MULTIMODAL IMAGING AND HISTOLOGIC CORRELATION OF ISOLATED METASTASIS OF PROSTATE ADENOCARCINOMA TO THE CHOROID
Authors: Cheung Albert Y. , Yonekawa Yoshihiro , Balaraman Savitha , Thomas Benjamin J. , Xi Alan M. , Folberg Robert , Amin Mitual , Miller Kay T. , Faia Lisa J. 
Published: April 2016

Purpose:
To provide correlative clinical-multimodal imaging-histopathologic findings of isolated prostatic choroidal metastasis.

Methods:
Ophthalmologic examination, fluorescein angiogram, spectral-domain optical coherence tomography, fundus autofluorescence, computerized tomography, magnetic resonance imaging, positive emission tomography, CSF analysis, serologies, tissue pathology with immunohistochemistry, and examination of relevant literature.

Results:
A 76-year-old man with a history of prostate adenocarcinoma was referred for 2 months of unilateral blurry vision. Fundus examination revealed elevated deep orange choroidal lesions in the macula with overlying retinal pigment epithelium mottling and subretinal fluid. Fluorescein angiogram demonstrated alternating areas of hypofluorescence and hyperfluorescence (staining) without leakage. Optical coherence tomography revealed dome-shaped and lumpy choroidal lesions with surrounding undulating “lumpy bumpy” and “rippled/seasick” patterns. Workup for a primary or additional metastatic lesion including computerized tomography of head/chest/abdomen/pelvis, lumbar puncture, magnetic resonance imaging brain, and whole-body positive emission tomography scan was negative. Full-thickness excisional chorioretinal biopsy was obtained through pars plana vitrectomy with diathermy and vertical scissors. Histologic examination revealed adenocarcinoma with weak positive staining for prostate specific antigen, moderate positive staining for P501S (prostein), and strong positive staining for prostatic acid phosphatase, consistent with metastasis from a prostate primary. Treatment consisted of local radiation with regression of the metastatic tumor. The patient is also on concomitant androgen deprivation treatment because there is a very high incidence of systemic recurrence due to hematogenous involvement. The patient's vision has continued to improve 6 months past treatment.

Conclusion:
The authors present a unique case to highlight the multimodal imaging and histology of a rare presentation of biopsy-proven, isolated metastasis of prostate adenocarcinoma to the choroid. Systemic workup is required, and if unrevealing of a primary or metastatic lesion, full-thickness chorioretinal biopsy and histopathology can provide a definitive diagnosis, allowing optimal treatment. Chorioretinal biopsy is a useful technique and may allow for visual preservation while also giving superior histologic quality.
PERIPHERAL RETINAL VASCULOPATHY IN COCKAYNE SYNDROME
Authors: Trese Matthew G. J. , Nudleman Eric D. , Besirli Cagri G. 
Published: April 2016

Purpose:
To present peripheral retinal vasculopathy and foveal ellipsoid zone abnormalities as novel fundus manifestations of Cockayne syndrome (CS), a rare autosomal recessive condition with well-described ophthalmic associations.

Methods:
Clinical examination, wide-field fundus photography, wide-field fundus autofluorescence, wide-field fluorescein angiography, and spectral domain optical coherence tomography (SD-OCT) were used to diagnose and document the patient's clinical presentation.

Results:
Our patient presented with postnatal growth delay, neurologic dysfunction, premature aging, dental anomalies, sensory neural hearing loss, and pigmentary retinopathy. This constellation of clinical features satisfies the clinical diagnostic criteria of CS Type 1. In addition to these well-known features, we used multimodal retinal imaging to perform an in-depth analysis of the retinal manifestations of CS and report peripheral vasculopathy and ellipsoid zone abnormality as two novel features which have not previously been described in conjunction with CS.

Conclusion:
This case report is intended to assist physicians in making the correct diagnosis of this rare condition by reviewing the clinical diagnostic criteria and providing the most comprehensive fundus imaging of CS available in the literature to date.
Alpha Phase Dynamics Predict Age-Related Visual Working Memory Decline
Authors: Tran Tam T. , Hoffner Nicole C. , LaHue Sara C. , Tseng Lisa , Voytek Bradley 
Published: April 2016

AbstractAlpha oscillations are modulated in response to visual temporal and spatial cues, However, the neural response to alerting cues is less explored, as is how this response is affected by healthy aging. Using scalp EEG, we examined how visual cortical alpha activity relates to working memory performance. Younger (20-30 years) and older (60-70 years) participants were presented with a visual alerting cue uninformative of the position or size of a lateralized working memory array. Older adults showed longer response times overall, and reduced accuracy when memory load was high. Older adults had less consistent cue-evoked phase resetting than younger adults, which predicted worse performance. Alpha phase prior to memory array presentation predicted response time, but the relationship between phase and response time was weaker in older adults. These results suggest that changes in alpha phase dynamics, especially prior to presentation of task-relevant stimuli, potentially contribute to age-related cognitive decline.
Influence of operational parameters on performance of twin thermoacoustic prime mover – CFD studies
Authors: P Jabbar , N.M Hariharan , Sivashanmugam Palani , Kasthurirengan S. 
Published: April 2016

Purpose
The present investigation deals with the analysis of the performance of twin thermoacoustic prime mover (TAPM) which are measured in terms of frequency and pressure amplitude by varying the parameters such as temperature gradient along the length of stack and the operating pressures of fluid medium argon using CFD simulation. With the help of CFD researchers and Engineers can evaluate the performance of a wide range of thermoacoustic systems on the computer without the time, expense, and disruption required to make actual changes onsite (stack) which is tedious to fabricate.

Design/methodology/approach
For the present simulation, the operating pressures of argon such as 1bar, 3bar and 5bar, and the temperature gradient is varied from 600K to 1400K with the regular intervals of each 200K. The geometry of twin TAPM is created using GAMBIT processor, and the simulation is carried out using FLUENT. The geometrical parameters of twin TAPM are kept constant throughout the simulation. The results for frequency and pressure amplitude obtained from the CFD simulation of twin TAPM for various temperature gradient and operating pressures are analysed and reported.

Findings
The computational results of twin thermoacoustic prime mover shows an increase in pressure amplitude with an increase in the temperature gradient and also it increases with an increase in operating pressures of the fluid medium. The parameter operating pressures of the working fluid medium and the stack hot end temperature has no significant effect on the output, frequency.

Originality/value
Though several experimental works had been published based on the twin thermoacoustic prime mover, an attempt has been made in the present investigation for the first time to estimate the performance of twin thermoacoustic prime mover using CFD package (ANSYS-FLUENT) by varying temperature gradient. The temperature gradient and operating pressures were varied and the performance of twin thermoacoustic prime mover was measured in terms of frequency and pressure amplitude.
Nonlinear dynamic co-rotational formulation for membrane elements with in-plane drilling rotational degree of freedom
Authors: Boutagouga Djamel , Djeghaba Kamel 
Published: April 2016

Purpose
nonlinear dynamic analysis of triangular and quadrilateral membrane elements with in-plane drilling rotational degree of freedom.

Design/methodology/approach
The nonlinear analysis is carried out using the updated co-rotational Lagrangian description. In this purpose, in-plane co-rotational formulation that considers the in-plane drilling rotation is developed and presented for triangular and quadrilateral elements, and a tangent stiffness matrix is derived. Furthermore, a simple and effective in-plane mass matrix that takes into account the in-plane rotational inertia, which permit true representation of in-plane vibrational modes is adopted for dynamic analysis, which is carried out using the Newmark direct time integration method.

Findings
The proposed numerical tests show that the presented elements exhibit very good performances and could return true in-plane rotational vibrational modes. Also, when using a well-chosen co-rotational formulation these elements shows good results for nonlinear static and dynamic analysis.

Originality/value
Publications that describe geometrical nonlinearity of the in-plane behaviour of membrane element with rotational d.o.f are few, and often they are based on the total Lagrangian formulation or on the rate form. Also these elements, at the author knowledge, have not been extended to the nonlinear dynamic analysis. Thus, an appropriate extension of triangular and quadrilateral membrane elements with drilling rotation to nonlinear dynamic analysis is required.
Hydrodynamic mechanism analysis of the pump hump district for a pump-turbine
Authors: Xiao Yexiang , Yao Yangyang , Wang Zhengwei , zhang jin , Luo Yongyao , Zeng Chongji , Zhu Wei 
Published: April 2016

Purpose
Numerically analyzed the flow characteristic and explored the hydrodynamic mechanism of the pump mode hump district formation of a Francis pump-turbine.

Design/methodology/approach
Numerical simulations were conducted of the entire pump-turbine flow passage under different discharge conditions by adopting the SST-CC turbulence model. The internal flow at hump district has been explained in detail combined with the model test in this paper. The unsteady flow and pressure fluctuation characteristics are analysed under five different discharge conditions in the hump and nearby region. The reason of the hump district formation is explored combined with the flow components hydraulic loss.

Findings
The large hydraulic loss, high relative peak-to-peak amplitudes and low dominant frequencies are on account of the disorganized internal flow condition. The formation of the hump district is concerned with the large hydraulic loss inside the draft tube, runner and guide vanes as there occurs secondary flow, backflow even vortex in the hump district. In addition, the low dominant frequencies at recording points inside the flow passage are always accompanied with the change of flow patterns and the spreading of the pressure fluctuations.

Originality/value
The analysis method of each flow components hydraulic loss combined with internal flow structure is adopted to explore the mechanism of pump mode hump characteristic. The flow characteristic and pressure pulse characteristics all correspond to the flow components hydraulic loss.
Thermal creep transition stresses and strain rates in a circular disc with shaft having variable density
Authors: Pankaj Thakur Dr , Kaur Jatinder , Bir Singh Satya 
Published: April 2016

PurposeThe purpose of this paper is to present study of thermal creep stresses and strain rates in a circular disc with shaft having variable density by using Seth’s transition theory.Design/methodology/approachSeth’s transition theory is applied to the problem of thermal creep transition stresses and strain rates in a thin rotating disc with shaft having variable density by finite deformation. Neither the yield criterion nor the associated flow rule is assumed here. The results obtained here are applicable to compressible materials. If the additional condition of incompressibility is imposed, then the expression for stresses corresponds to those arising from Tresca yield condition.FindingsThermal effect increased value of radial stress at the internal surface of the rotating disc made of incompressible material as compared to tangential stress and this value of radial stress further much increases with the increase in angular speed as compared to without thermal effect. Strain rates have maximum values at the internal surface for compressible material.Originality/valueThe model proposed in this paper is used in mechanical and electronic devices. They have extensive practical engineering application such as in steam and gas turbines, turbo generators, flywheel of internal combustion engines, turbojet engines, reciprocating engines, centrifugal compressors and brake disks.
Reduced time from diagnosis to stone-free status in patients with ureteral calculi – a quantitative study
Authors: Khatami Annelie , Rosengren Kristina 
Published: April 2016

Purpose
Purpose - The aim was to describe an improvement project and its effects on decreasing the time from diagnosis to treatment for patients with kidney stones and to reduce the negative effects related to untreated stones at one hospital in western Sweden

Design/methodology/approach
Design and methodology - A quantitative descriptive study based on Nolan’s improvement model was used. The quality improvement effects were evaluated using statistical process control (SPC).

Findings
Findings – Extracorporeal shock wave lithotripsy ESWL treatment’s positive effects within 48 hours were described as efficiency (decreased waiting time) from diagnosis to treatment, even if a re-treatment was necessary. The results also showed a reduction in the usage of percutaneous nephropyelostomies as a treatment option.

Research limitations/implications
Research limitations - This study includes data from one department at one hospital in one country. Comparative data include the time from acute radiological examination to final treatment but not total re-treatments, complications or time to up following radiological examination. However, the study was performed over one year and analyzed data from medical records in a systematic way.

Practical implications
Practical implications - This study may inspire measuring and developing routines from diagnosis to treatment for patients who are transferred within different departments at one hospital.

Originality/value
Originality - Studies in improvement projects considering ureteral or kidney stones are generally lacking; thus, this study is important for improving the care of patients with this diagnose.
Do migrants pass their work ethic to their children? Evidence from the Honduran national household survey
Authors: Chen Xudong , Lin Yingge , Noiset Luc P 
Published: April 2016

Purpose– The scholarly literature that examines the economic assimilation of migrant families has focussed on the educational and economic achievements of the children of international migrants relative to the children of native born parents. Lower relative incomes of the children of immigrants might be attributable to discrimination, while higher relative incomes could be attributable to ambitious parents who produce more ambitious children. These potential effects have been difficult to disentangle. The purpose of this paper is to control for discrimination by examining internal migration in Honduras, allowing us to isolate evidence for or against the “ambition” effect.Design/methodology/approach– The paper uses the Blinder-Oaxaca decomposition technique to ask if the children of migrants are similar or different than their parents in their attitudes toward work and economic advancement.Findings– This study finds that migrants are relatively hard workers in the sense that they experience relatively high marginal effects on earnings from improved socio-economic characteristics, such as years of schooling. The study also finds that these migrants do not pass on this hard-work ethic to their children, who experience much smaller marginal effects from increased years of schooling and other socio-economic characteristics.Originality/value– This study demonstrates that the children of migrants do not necessarily inherit the ambitious work ethic characteristic of their migrant parents. This result has important implications for studies that examine the assimilation and economic progress of migrant families, particularly those studies that use second-generation earnings as a measure of assimilation and economic progress.
Benefits and risks of shared services in healthcare
Authors: Kennewell Suzanne , Baker Laura 
Published: April 2016

Purpose
– The purpose of this paper is to explore the experiences of staff in a large, public health service involved in transitioning support services to a shared services model. It aims to understand their perceptions of the benefits and risks arising from this change.

Design/methodology/approach
– Thematic analysis of qualitative data from semi-structured interviews with both service provider and customer agency staff was used to identify, analyze and report patterns of benefits and risks within data.

Findings
– Staff expressed the need for relevant subject-matter-experts to work within customer agencies to facilitate effective communication between the customer agency and shared services provider, reflecting observations found in out-sourcing literature.

Research limitations/implications
– Results point to significant challenges continuing to occur for shared services in healthcare. Risks identified suggest a more intimate relationship between clinical and support services than previously discussed.

Originality/value
– Previous discussion of the shared services model has not considered the skills, knowledge and ability required by staff in the customer agency. This research indicates that in the absence of such consideration, the concepts of the shared services model are weakened.
Implementing a new governance model
Authors: Stanley-Clarke Nicky , Sanders Jackie , Munford Robyn 
Published: April 2016

Purpose
– The purpose of this paper is to discuss the lessons learnt from the process of implementing a new model of governance within Living Well, a New Zealand statutory mental health agency.

Design/methodology/approach
– It presents the findings from an organisational case study that involved qualitative interviews, meeting observations and document analysis. Archetype theory provided the analytical framework for the research enabling an analysis of both the formal structures and informal value systems that influenced the implementation of the governance model.

Findings
– The research found that the move to a new governance model did not proceed as planned. It highlighted the importance of staff commitment, the complexity of adopting a new philosophical approach and the undue influence of key personalities as key determining factors in the implementation process. The findings suggest that planners and managers within statutory mental health agencies need to consider the implications of any proposed governance change on existing roles and relationships, thinking strategically about how to secure professional commitment to change.

Practical implications
– There are ongoing pressures within statutory mental health agencies to improve the efficiency and effectiveness of organisational structures and systems. This paper has implications for how planners and managers think about the process of implementing new governance models within the statutory mental health environment in order to increase the likelihood of sustaining and embedding new approaches to service delivery.

Originality/value
– The paper presents insights into the process of implementing new governance models within a statutory mental health agency in New Zealand that has relevance for other jurisdictions.
Analysis of introducing e-services: a case study of Health Insurance Fund of Macedonia
Authors: Gavrilov Goce , Vlahu- Gjorgievska Elena , Trajkovik Vladimir 
Published: April 2016

Purpose
– Information systems play a significant role in the improving of health and healthcare, as well as in the planning and financing of health services. Fund’s Information System is an essential component of the information infrastructure that allows assessment of the impact of changes in health insurance and healthcare for the population. The purpose of this paper is to give a brief overview of the affection of e-services and electronic data exchange (between Fund’s information systems and other IT systems) at the quality of service for insured people and savings funds.

Design/methodology/approach
– The authors opted for an exploratory study using the e-services implemented in Health Insurance Fund (HIF) of Macedonia and data which were complemented by documentary analysis, including brand documents and descriptions of internal processes. In this paper is presented an analysis of the financial aspects of some e-services in HIF of Macedonia by using computer-based information systems and calculating the financial implications on insured people, companies and healthcare providers.

Findings
– The analysis conducted in this paper shows that the HIF’s e-services would have a positive impact for the insured people, healthcare providers and companies when fulfilling their administrative obligations and exercising their rights.

Originality/value
– The analysis presented in this paper can serve as a valuable input for the healthcare authorities in making decisions related to introducing e-services in healthcare. These enhanced e-services will improve the quality service of the HIF.