bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling the Roles of Subducted Volatile Contributions and Mantle Source Heterogeneity in the Production of Magmas Beneath the Washington Cascades
Authors: Walowski K. J. , Wallace P. J. , DeBari S. M. , Wada I. , Shaw S. D. , Rea J. 
Published: September 2024

AbstractThe compositional diversity of primitive arc basalts has long inspired questions regarding the drivers of magmatism in subduction zones, including the roles of decompression melting, mantle heterogeneity, and the amount and composition of slab‐derived materials. This contribution presents the volatile (H2O, Cl, and S), major, and trace element compositions of melt inclusions from basaltic magmas erupted at three volcanic centers in the Washington Cascades: Mount St. Helens (two basaltic tephras, 2.0–1.7 ka), Indian Heaven Volcanic Field (two <600 ka basaltic hyaloclastite tuffs), and Glacier Peak (late Pleistocene to Holocene basaltic tephra from Whitechuck and Indian Pass cones). Compositions corrected to be in equilibrium with mantle olivine display variability in Nb and trace element ratios indicative of mantle source variability that impressively spans nearly the entire range of arc magmas globally. All volcanic centers have magmas with H2O and Cl contributions from the downgoing plate that overlap with other Cascade Arc segments. Volatile abundances and trace element ratios support a model of melting of a highly variably mantle wedge driven by a subduction component of variably saline fluid and/or slab partial melt. Magmas from Glacier Peak in northern Washington have unusually high Th/Yb ratios that are similar to Lassen region basalts, indicating possible contributions of “subcreted” metasediments that geophysical data suggest are not present beneath central Oregon and southern Washington. This data set adds to the growing inventory of primitive magma volatile concentrations and provides insight into spatial distributions of mantle heterogeneity and the role of slab components in the petrogenesis of arc magmas.
Air‐Ice‐Ocean Coupling During a Strong Mid‐Winter Cyclone: Observing Coupled Dynamic Interactions Across Scales
Authors: Watkins D. M. , Persson P. O. G. , Stanton T. , Solomon A. , Hutchings J. K. , Haapala J. , Svensson G. 
Published: September 2024

AbstractArctic cyclones are key drivers of sea ice and ocean variability. During the 2019–2020 Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition, joint observations of the coupled air‐ice‐ocean system were collected at multiple spatial scales. Here, we present observations of a strong mid‐winter cyclone that impacted the MOSAiC site as it drifted in the central Arctic pack ice. The sea ice dynamical response showed spatial structure at the scale of the evolving and translating cyclonic wind field. Internal ice stress and ocean stress play significant roles, resulting in timing offsets between the atmospheric forcing and the ice response and post‐cyclone inertial ringing in the ice and ocean. Ice motion in response to the wind field then forces the upper ocean currents through frictional drag. The strongest impacts to the sea ice and ocean from the passing cyclone occur as a result of the surface impacts of a strong atmospheric low‐level jet (LLJ) behind the trailing cold front and changing wind directions between the warm‐sector LLJ and post cold‐frontal LLJ. Impacts of the cyclone are prolonged through the coupled ice‐ocean inertial response. Local impacts of the approximately 120 km wide LLJ occur over a 12 hr period or less and at scales of a kilometer to a few tens of kilometers, meaning that these impacts occur at combined smaller spatial scales and faster time scales than most satellite observations and coupled Earth system models can resolve.
Distinct binding conformations of epinephrine with α- and β-adrenergic receptors
Authors: Lou Jian-Shu , Su Minfei , Wang Jinan , Do Hung Nguyen , Miao Yinglong , Huang Xin-Yun 
Published: September 2024

AbstractAgonists targeting α2-adrenergic receptors (ARs) are used to treat diverse conditions, including hypertension, attention-deficit/hyperactivity disorder, pain, panic disorders, opioid and alcohol withdrawal symptoms, and cigarette cravings. These receptors transduce signals through heterotrimeric Gi proteins. Here, we elucidated cryo-EM structures that depict α2A-AR in complex with Gi proteins, along with the endogenous agonist epinephrine or the synthetic agonist dexmedetomidine. Molecular dynamics simulations and functional studies reinforce the results of the structural revelations. Our investigation revealed that epinephrine exhibits different conformations when engaging with α-ARs and β-ARs. Furthermore, α2A-AR and β1-AR (primarily coupled to Gs, with secondary associations to Gi) were compared and found to exhibit different interactions with Gi proteins. Notably, the stability of the epinephrine–α2A-AR–Gi complex is greater than that of the dexmedetomidine–α2A-AR–Gi complex. These findings substantiate and improve our knowledge on the intricate signaling mechanisms orchestrated by ARs and concurrently shed light on the regulation of α-ARs and β-ARs by epinephrine.
Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends
Authors: Im Se Jin , Lee Kyungmin , Ha Sang-Jun 
Published: September 2024

AbstractIL-2 therapy, which enhances the function of CD8 + T cells, was initially employed as the cornerstone of immunotherapy against cancer. However, the impact of this therapy extends beyond CD8 + T cells to cells expressing IL-2R, such as endothelial cells and regulatory T cells (Tregs), resulting in various side effects. Consequently, IL-2 therapy has taken a step back from the forefront of treatment. Immune checkpoint inhibitors (ICIs), such as anti-PD-1/PD-L1 antibodies and CTLA-4 antibodies, are used because of their durable therapeutic responses and the reduced incidence of side effects. Nevertheless, only a small fraction of cancer patients respond to ICIs, and research on IL-2 as a combination treatment to improve the efficacy of these ICIs is ongoing. To mitigate side effects, efforts have focused on developing IL-2 variants that do not strongly bind to cells expressing IL-2Rα and favor signaling through IL-2Rβγ. However, recent studies have suggested that, in the context of persistent antigen stimulation models, effective stimulation of antigen-specific exhausted CD8 + T cells in combination with PD-1 inhibitors requires either 1) binding to IL-2Rα or 2) delivery via a fusion with PD-1. This review explores the historical context of IL-2 as an immunotherapeutic agent and discusses future directions for its use in cancer immunotherapy.
Mosaic chromosomal alterations in hematopoietic cells and clinical outcomes in patients with multiple myeloma
Authors: Husby Simon , Tulstrup Morten , Harsløf Mads , Nielsen Christian , Haastrup Eva , Ebbesen Lene Hyldahl , Klarskov Andersen Mette , Pertesi Maroulio , Brieghel Christian , Niemann Carsten U. , Nilsson Björn , Szabo Agoston Gyula , Andersen Niels Frost , Abildgaard Niels , Vangsted Annette , Grønbæk Kirsten 
Published: September 2024

AbstractMosaic chromosomal alterations (mCAs) in hematopoietic cells increase mortality and risk of hematological cancers and infections. We investigated the landscape of mCAs and their clinical consequences in 976 patients with multiple myeloma undergoing high-dose chemotherapy and autologous stem cell support (ASCT) with median 6.4 years of follow-up. mCAs were detected in the stem cell harvest product of 158 patients (16.2%). Autosomal aberrations were found in 60 patients (6.1%) and affected all chromosomes. Loss of chromosome X was found in 51 females (12.7%) and loss of chromosome Y in 55 males (9.6%). Overall survival and progression were similar between carriers of autosomal mCAs and non-carriers. In contrast, female patients with loss of the X chromosome had longer overall survival (age-adjusted[a.a.] HR 0.54, 95% CI 0.32–0.93, p = 0.02), lower risk of progression (a.a. HR 0.55, 95% CI 0.35–0.87; p = 0.01), and better post-transplant response (higher degree of complete response (CR) or very good partial response (VGPR)). The reason for this substantial effect is unknown. Additionally, myeloma clones in the stem cell product was confirmed by mCA analysis in the few patients with multiple mCAs (n = 12 patients). Multiple mCAs conferred inferior overall survival (a.a. HR 2.0, 95% CI 1.02–3.84; p = 0.04) and higher risk of myeloma progression (a.a. HR 3.36, 95% CI 1.67–6.81; p < 0.001), which is presumed to be driven by suspected myeloma contaminants.
The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity
Authors: Kendler Kenneth S. , Ohlsson Henrik , Sundquist Jan , Sundquist Kristina 
Published: September 2024

Abstract
We investigate whether number of episodes (NoEs) meaningfully reflect genetic risk and genetic heterogeneity for five primary disorders—Drug Use Disorder (DUD), Alcohol Use Disorder (AUD), Major Depression (MD), Bipolar Disorder (BD), and Schizophrenia (SZ) ascertained from Swedish population registries. We utilize Genetic Risk Ratios (GRR)—defined as the ratio of the genetic risk for secondary disorders to the genetic risk for the primary disorder—derived from Family Genetic Risk Scores (FGRS). For all five primary disorders, genetic risk rose robustly with increasing NoEs. For both AUD and DUD, the GRR for all six secondary disorders—selected to have a likely genetic relationship with the particular primary disorder—declined with increasing NoEs so that cases of AUD and DUD with high versus low NoEs had both a higher genetic risk and a purer genetic signal. With MD, genetic risk maximized at an intermediate NoEs. While the GRRs for AUD and DUD in MD cases dropped sharply with increasing NoEs, GRR for BD increased. For BD, genetic risk rose sharply with increasing NoEs while for all secondary disorders the GRRs showed a mixture of modest increases and decreases. Like AUD and DUD, but even more markedly, selecting BD cases with high rates of recurrence would produce a sample with a high overall genetic risk and a relatively homogeneous genetic signal. For SZ, genetic risk rose moderately with increases in NoEs. GRRs for other non-affective psychoses (ONAP) and autism spectrum disorder (ASD) fell quite slowly with increasing NoEs, and more rapidly for other secondary disorders. Cases of SZ with high recurrence rates had a high genetic risk and a relatively pure signal, albeit with contributions from ONAP and ASD. In summary, NOEs are a robust index of genetic risk and genetic heterogeneity across our primary disorders with important inter-disorder differences.
Umbilical cord management in newborn resuscitation: a systematic review and meta-analysis
Authors: Major Gréta Sz. , Unger Vivien , Nagy Rita , Hernádfői Márk , Veres Dániel S. , Zolcsák Ádám , Szabó Miklós , Garami Miklós , Hegyi Péter , Varga Péter , Gasparics Ákos 
Published: September 2024

Abstract
Background
Evidence supporting the benefits of delayed cord clamping is increasing; however, there is no clear recommendation on cord management during newborn resuscitation. This study aimed to investigate the effects of resuscitation initiated with an intact umbilical cord, hypothesizing it is a safe stabilization procedure that improves neonatal outcomes.

Methods
Systematic search was conducted in MEDLINE, Embase, CENTRAL, and Web of Science from inception to March 1, 2024. Eligible articles compared neonatal outcomes in newborns receiving initial stabilization steps before and after cord clamping.

Results
Twelve studies met our inclusion criteria, with six RCTs included in the quantitative analysis. No statistically significant differences were found in delivery room parameters, in-hospital mortality, or neonatal outcomes between the examined groups. However, intact cord resuscitation group showed higher SpO2 at 5 min after birth compared to cord clamping prior to resuscitation group (MD 6.67%, 95% CI [−1.16%, 14.50%]). There were no significant differences in early complications of prematurity (NEC ≥ stage 2: RR 2.05, 95% CI [0.34, 12.30], IVH: RR 1.25, 95% CI [0.77, 2.00]).

Conclusion
Intact cord management during resuscitation appears to be a safe intervention; its effect on early complications of prematurity remains unclear. Further high-quality RCTs with larger patient numbers are urgently needed.

Impact

Initiating resuscitation with an intact umbilical cord appears to be a safe intervention for newborns.

No statistically significant differences were found in delivery room parameters, in-hospital mortality, and neonatal outcomes between the examined groups.

The utilization of specialized resuscitation trolleys appears to be promising to reduce the risk of intraventricular hemorrhage in preterm infants.

Further high-quality RCTs with larger sample sizes are urgently needed to refine recommendations.
Peritumoral tissue (PTT): increasing need for naming convention
Authors: Koca Dzenis , Abedi-Ardekani Behnoush , LeMaoult Joel , Guyon Laurent 
Published: September 2024

AbstractVarious terms are used to describe non-malignant tissue located in the proximity of a tumor, belonging to the organ from which the tumor originated. Traditionally, these tissues, sometimes called “normal adjacent tissue” have been used as controls in cancer studies, and were considered representative of morphologically healthy, non-cancerous tissue. However, with the advancement of OMIC technologies, such tissues are increasingly recognized to be distinct from both tumor and healthy tissues. Furthermore, properties, characteristics, and role of these tissues in cancer formation and progression is increasingly studied. In order to make future research in this area more harmonized and more accessible, as well as to counter the widespread perception of normalcy, we are advocating the need for standardized naming convention. For this purpose, we propose the use of neutral and comprehensive term “Peritumoral Tissue” along with the acronym “PTT”. While significant amount of data on these tissues are publicly available, reuse of such data remains limited due to a lack of information on sample collection procedures. In order to facilitate future reuse of the data, we suggest a list of features that should be documented during sample collection procedures. These recommendations can aid the definition of Standard Operating Procedures.
MadQCI: a heterogeneous and scalable SDN-QKD network deployed in production facilities
Authors: Martin V. , Brito J. P. , Ortíz L. , Méndez R. B. , Buruaga J. S. , Vicente R. J. , Sebastián-Lombraña A. , Rincón D. , Pérez F. , Sánchez C. , Peev M. , Brunner H. H. , Fung F. , Poppe A. , Fröwis F. , Shields A. J. , Woodward R. I. , Griesser H. , Roehrich S. , de la Iglesia F. , Abellán C. , Hentschel M. , Rivas-Moscoso J. M. , Pastor-Perales A. , Folgueira J. , López D. 
Published: September 2024

AbstractCurrent quantum key distribution (QKD) networks focus almost exclusively on transporting secret keys at the highest possible rate. Consequently, they are built as mostly fixed, ad hoc, logically, and physically isolated infrastructures designed to avoid any penalty to the quantum channel. This architecture is neither scalable nor cost-effective and future, real-world deployments will differ considerably. The structure of the MadQCI QKD network presented here is based on disaggregated components and modern paradigms especially designed for flexibility, upgradability, and facilitating the integration of QKD in the security and telecommunications-networks ecosystem. These underlying ideas have been tested by deploying many QKD systems from several manufacturers in a real-world, multi-tenant telecommunications network, installed in production facilities and sharing the infrastructure with commercial traffic. Different technologies have been used in different links to address the variety of situations and needs that arise in real networks, exploring a wide range of possibilities. Finally, a set of realistic use cases has been implemented to demonstrate the validity and performance of the network. The testing took place during a period close to three years, where most of the nodes were continuously active.
Induction of oxidative- and endoplasmic-reticulum-stress dependent apoptosis in pancreatic cancer cell lines by DDOST knockdown
Authors: Böhme Richard , Schmidt Andreas W. , Hesselbarth Nico , Posern Guido , Sinz Andrea , Ihling Christian , Michl Patrick , Laumen Helmut , Rosendahl Jonas 
Published: September 2024

AbstractThe dolichyl-diphosphooligosaccharide-protein glycosyltransferase non-catalytic subunit (DDOST) is a key component of the oligosaccharyltransferase complex catalyzing N-linked glycosylation in the endoplasmic reticulum lumen. DDOST is associated with several cancers and congenital disorders of glycosylation. However, its role in pancreatic cancer remains elusive, despite its enriched pancreatic expression. Using quantitative mass spectrometry, we identify 30 differentially expressed proteins and phosphopeptides (DEPs) after DDOST knockdown in the pancreatic ductal adenocarcinoma (PDAC) cell line PA-TU-8988T. We evaluated DDOST / DEP protein–protein interaction networks using STRING database, correlation of mRNA levels in pancreatic cancer TCGA data, and biological processes annotated to DEPs in Gene Ontology database. The inferred DDOST regulated phenotypes were experimentally verified in two PDAC cell lines, PA-TU-8988T and BXPC-3. We found decreased proliferation and cell viability after DDOST knockdown, whereas ER-stress, ROS-formation and apoptosis were increased. In conclusion, our results support an oncogenic role of DDOST in PDAC by intercepting cell stress events and thereby reducing apoptosis. As such, DDOST might be a potential biomarker and therapeutic target for PDAC.
Abscisic acid improves drought resilience, growth, physio-biochemical and quality attributes in wheat (Triticum aestivum L.) at critical growth stages
Authors: Zulfiqar Bilal , Raza Muhammad Aown Sammar , Saleem Muhammad Farrukh , Ali Baber , Aslam Muhammad Usman , Al-Ghamdi Abdullah Ahmed , Elshikh Mohamed S. , Hassan Mahmood Ul , Toleikienė Monika , Ahmed Junaid , Rizwan Muhammad , Iqbal Rashid 
Published: September 2024

AbstractWheat is an important staple crop not only in Pakistan but all over the globe. Although the area dedicated to wheat cultivation expands annually, the quantity of wheat harvested is declining due to various biotic and abiotic factors. Global wheat production and output have suffered as a result of the drought, which is largely driven by a lack of water and environmental factors. Organic fertilizers have been shown to reduce the severity of drought. The current research was conducted in semi-arid climates to mitigate the negative effects of drought on wheat during its critical tillering (DTS), flowering (DFS), and grain filling (DGFS) stages through the application of three different abscisic acid treatments: ABA0 (0 mgL−1) control, ABA1 (100 mgL−1) and ABA2 (200 mgL−1). Wheat growth and yield characteristics were severely harmed by drought stress across all critical development stages, with the DGFS stage being particularly vulnerable and leading to a considerable loss in yield. Plant height was increased by 24.25%, the number of fertile tillers by 25.66%, spike length by 17.24%, the number of spikelets per spike by 16.68%, grain count per spike by 11.98%, thousand-grain weight by 14.34%, grain yield by 26.93% and biological yield by 14.55% when abscisic acid (ABA) was applied instead of the control treatment. Moreover, ABA2 increased the more physiological indices (water use efficiency (36.12%), stomatal conductance (44.23%), chlorophyll a (24.5%), chlorophyll b (29.8%), transpiration rate (23.03%), photosynthetic rate (24.84%), electrolyte leakage (− 38.76%) hydrogen peroxide (− 18.09%) superoxide dismutase (15.3%), catalase (20.8%), peroxidase (− 18.09%), and malondialdehyde (− 13.7%)) of drought-stressed wheat as compared to other treatments. In the case of N, P, and K contents in grain were maximally improved with the application of ABA2. Through the use of principal component analysis, we were able to correlate our results across scales and provide an explanation for the observed effects of ABA on wheat growth and production under arid conditions. Overall, ABA application at a rate of 200 mgL−1 is an effective technique to boost wheat grain output by mitigating the negative effects of drought stress.
Cost-effective soft-switching ultra-high step-up DC–DC converter with high power density for DC microgrid application
Authors: Nadermohammadi Ali , Abolhassani Pouya , Seifi Ali , Zarrinehbafan Mohammadreza , Aghakhanlou Pouneh , Hosseini Seyed Hossein , Sabahi Mehran 
Published: September 2024

AbstractDC microgrids are integral to smart grids, enhancing grid reliability, power quality, and energy efficiency while enabling individual grid independence. They combine distributed and renewable energy sources, reducing overall energy consumption. High-gain DC–DC converters are crucial for elevating voltages from low-voltage DC sources like solar panels and wind turbines in DC microgrids. This paper introduces a non-isolated DC–DC converter designed to achieve ultra-high step-up (UHSU) voltage conversion utilizing a two-winding coupled inductor (CI). The propounded UHSU configuration achieves a substantial voltage increase by employing low duty cycles and a decreased turn ratio for the CI, resulting in a smaller core size. Moreover, this UHSU circuit incorporates soft-switching capabilities for both power switches and diodes, enhancing its efficiency. By keeping the voltage stress on the switches low, the design minimizes losses and improves overall efficiency. The operational modes are thoroughly analyzed, and comparisons with other topologies are presented to demonstrate the effectiveness of the proffered UHSU circuit. Finally, the performance of the UHSU circuit is validated through the construction and testing of a 150-W laboratory prototype operating at a switching frequency of 50 kHz, with Vin = 20 V and Vout = 300 V.
The carbon emission reduction effect of green fiscal policy: a quasi-natural experiment
Authors: Wang Shuguang , Zhang Zequn , Zhou Zhicheng , Zhong Shen 
Published: September 2024

AbstractCarbon emission reduction is crucial for mitigating global climate change, and green fiscal policies, through providing economic incentives and reallocating resources, are key means to achieve carbon reduction targets. This paper uses data covering 248 cities from 2003 to 2019 and applies a multi-period difference-in-differences model (DID) to thoroughly assess the impact of energy conservation and emission reduction (ECER) fiscal policies on enhancing carbon emission (CE1) reduction and carbon efficiency (CE2). It further analyzes the mediating role of Green Innovation (GI), exploring how it strengthens the impact of ECER policies. We find that: (1) ECER policies significantly promote the improvement of carbon reduction and CE2, a conclusion that remains robust after excluding the impacts of concurrent policy influences, sample selection biases, outliers, and other random factors. (2) ECER policies enhance CE1 reduction and CE2 in pilot cities by promoting green innovation, and this conclusion is confirmed by Sobel Z tests. (3) The effects of ECER policies on CE1 reduction and the improvement of CE2 are more pronounced in higher-level cities, the eastern regions and non-resource cities. This research provides policy makers with suggestions, highlighting that incentivizing green innovation through green fiscal policies is an effective path to achieving carbon reduction goals.