bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Respiratory Decompensation Among Healthy Infants With Bronchiolitis
Authors: Dadlez Nina M. , Esteban-Cruciani Nora , Khan Asama , Douglas Lindsey C. , Shi Yi , Southern William N. 
Published: September 2017

BACKGROUND:
Although most children with bronchiolitis only require supportive care, some decompensate and require ventilatory support. We examined predictors of respiratory decompensation among hospitalized children to identify which patients may benefit from expectant monitoring.

METHODS:
We examined children ≤24 months old with bronchiolitis admitted to the general infant and toddler floor. Children with pneumonia or comorbidities were excluded. Demographic and clinical characteristics were abstracted from a clinical database and medical records. Respiratory decompensation was defined as the need for initiating high-flow nasal cannula oxygen, continuous positive airway pressure, nasal intermittent mandatory ventilation, bilevel positive airway pressure, or intubation. A multivariable logistic regression model was constructed to identify independent predictors of respiratory decompensation.

RESULTS:
A total of 1217 children were included. The median age was 6.9 months, 41% were girls, 49% were Hispanic, 21% were black, and 18% were premature. Significant independent predictors of respiratory decompensation were age ≤3 months (odds ratio [OR]: 3.25; 95% confidence interval [CI]: 2.09–5.07), age 3 to 6 months (OR: 1.76; 95% CI: 1.04–3.0), black race (OR: 1.94; 95% CI: 1.27–2.95), emergency department hypoxemia (OR: 2.34; 95% CI: 1.30–4.21), and retractions or accessory muscle use (OR: 2.26; 95% CI: 1.48–3.46). Children with 0 of 4 predictors were found to have a low risk of decompensation (3%).

CONCLUSIONS:
Young age, black race, emergency department hypoxemia, and retractions or accessory muscle use were associated with respiratory decompensation in children with bronchiolitis. These factors should be considered at presentation, as they identify children who require a higher level of respiratory monitoring and support and others who may not benefit.
Parent-Child Interaction Therapy: A Meta-analysis
Authors: Thomas Rae , Abell Bridget , Webb Haley J. , Avdagic Elbina , Zimmer-Gembeck Melanie J. 
Published: September 2017

CONTEXT:
Parent-child interaction therapy (PCIT) is effective at reducing children’s externalizing behavior. However, modifications are often made to PCIT, and it is not known whether these impact effectiveness.

OBJECTIVE:
To systematically review and meta-analyze the effects of PCIT on child externalizing behaviors, considering modifications, study design, and bias.

DATA SOURCES:
We searched PubMed, PsycINFO, Education Resources Information Center, Sociological Abstracts, and A+ Education.

STUDY SELECTION:
We selected randomized controlled or quasi-experimental trials.

DATA EXTRACTION:
We analyzed child externalizing and internalizing behaviors, parent stress, parent-child interactions, PCIT format, and study design and/or characteristics.

RESULTS:
We included 23 studies (1144 participants). PCIT was superior to control for reducing child externalizing (standardized mean difference [SMD]: −0.87, 95% confidence interval [CI]:−1.17 to −0.58). PCIT studies that required skill mastery had significantly greater reductions in externalizing behavior than those that did not (Mastery: SMD: −1.09, 95% CI: −1.44 to −0.73; Nonmastery: SMD: −0.51,95% CI: −0.85 to −0.17, P = .02). Compared with controls, PCIT significantly reduced parent-related stress (mean difference [MD]: −6.98, 95% CI: −11.69 to −2.27) and child-related stress (MD: −9.87, 95% CI: −13.64 to −6.09). Children in PCIT were observed to be more compliant to parent requests (SMD: 0.89, 95% CI: 0.50 to 1.28) compared with controls. PCIT effectiveness did not differ depending on session length, location (academic versus community settings), or child problems (disruptive behaviors only compared with disruptive behavior and other problems).

LIMITATIONS:
Results for parent-child observations were inconsistently reported, reducing the ability to pool important data.

CONCLUSIONS:
PCIT has robust positive outcomes across multiple parent-reported and observed parent-child interaction measures, and modifications may not be required even when implemented in diverse populations.
Outcomes of Advanced Gastric Cancer Patients Treated with at Least Three Lines of Systemic Chemotherapy
Authors: Fanotto Valentina , Uccello Mario , Pecora Irene , Rimassa Lorenza , Leone Francesco , Rosati Gerardo , Santini Daniele , Giampieri Riccardo , Di Donato Samantha , Tomasello Gianluca , Silvestris Nicola , Pietrantonio Filippo , Battaglin Francesca , Avallone Antonio , Scartozzi Mario , Lutrino Eufemia Stefania , Melisi Davide , Antonuzzo Lorenzo , Pellegrino Antonio , Ferrari Laura , Bordonaro Roberto , Vivaldi Caterina , Gerratana Lorenzo , Bozzarelli Silvia , Filippi Roberto , Bilancia Domenico , Russano Marco , Aprile Giuseppe 
Published: September 2017

Abstract

Background
Second-line therapy has consistently demonstrated survival benefit if compared with best supportive care; however, there is limited evidence whether further lines of treatment may improve the prognosis of advanced gastric cancer (AGC) patients.

Materials and Methods
Starting from a real-world cohort of 868 AGC patients, we retrospectively analyzed baseline parameters, tumor characteristics, and treatment data of those treated with at least three lines. Categorical features were described through cross-tables and chi-square test. We explored the impact of treatment intensity and progression-free survival (PFS) experienced in previous lines on PFS and overall survival in third-line by uni- and multivariate Cox regression models and described by Kaplan-Meier estimator plot with log-rank test.

Results
Overall, 300 patients were included in the analysis. The most common site of primary tumor was gastric body; 45.3% of cancers had an intestinal histotype, 14% were human epidermal growth receptor 2 positive. In third-line, 45.7% of patients received a single-agent chemotherapy, 49.7% a combination regimen. Patients who had experienced a first-line PFS ≥6.9 months had a better prognosis compared with those who had achieved a shorter one. Consistently, a second-line PFS ≥3.5 months positively influenced the prognosis. Patients receiving a third-line combination regimen had better outcomes compared with those treated with a single-agent chemotherapy.

Conclusion
Our real-world study confirms that selected AGC patients may receive third-line treatment. Longer PFS in previous lines or a more intense third-line treatment positively influenced prognosis. Further efforts are warranted to define the best therapeutic sequences, and to identify the optimal candidate for treatment beyond second-line.
Next-Generation Sequencing for Patients with Sarcoma: A Single Center Experience
Authors: Cote Gregory M. , He Jie , Choy Edwin 
Published: September 2017

Abstract

Background
Sarcomas comprise over 50 subtypes of mesenchymal cancers. For the majority of sarcomas, the driver mutations remain unknown. In this article, we describe our experience with a targeted next-generation sequencing (NGS) platform in clinic patients.

Materials and Methods
We retrospectively analyzed results of NGS using 133 tumor samples from patients diagnosed with a variety of sarcomas that were analyzed with targeted NGS covering over 400 cancer-related genes (405 DNA, 265 RNA) on a commercially available platform.

Results
An average of two gene alterations were identified per tumor sample (range 0–14), and a total of 342 DNA mutations were detected. Eight-eight percent of samples had at least one detected mutation. The most common mutations were in the cell cycle, including TP53 (n = 35), CDKN2A/B (n = 23), and RB1 (n = 19). Twenty-seven PI3-kinase pathway alterations were observed, including PTEN (n = 14), PIK3Ca (n = 4), TSC1 (n = 1), TSC2 (n = 3), STK11 (n = 1), mTOR (n = 3), and RICTOR (n = 2). There were 75 mutations in genes that are targetable with existing drugs (excluding KIT in gastrointestinal stromal tumor) that would allow enrollment onto clinical trials. In general, the estimated tumor mutation burden was low, in particular for those with disease-defining gene fusions or genetic alterations. Microsatellite instability (MSI) data were available for 50 patients, and all were MSI stable.

Conclusion
Our study describes a single-center experience with targeted NGS for patients with sarcoma. Mutations were readily detected and 75 (representing 40% of patients) were testable for therapeutic effect using existing drugs within the confines of a clinical trial. These data indicate that targeted NGS is a useful tool in potentially routing patients to mutation-specific clinical trials. Further study will be required to determine if these mutations are clinically meaningful drug targets in sarcoma.

Implications for Practice
The sarcomas are a heterogenous family of over 50 different mesenchymal tumors. Current practice for metastatic disease involves systemic chemotherapy or nonspecific kinase inhibitors such as pazopanib. Sarcomas typically lack the classic kinase alterations seen in many carcinomas. The role of next-generation sequencing in sarcoma clinical practice remains undefined.
Apresentação do Dossiê: “Rememorando o Sesquicentenário da Confederação no Canadá (1867-2017)”
Authors: Bernd Zilá , Berg Oscar Augusto 
Published: September 2017

Apresentação do dossiê temático sobre o Sesquicentenário da confederação canadense, salientando os detalhes das quatro contribuições que compõem o dossiê temático que inclui uma entrevista com o diretor do Centre International de la francophoni com sede em Quebec. O dossier conta ainda com aparticipação da colega Ofelia Scher da Unviersidad de Buenos Aires, com artigo composto em parcceria com aprofa. Tatiana Maia e scar Berg e com uma tradução realaizada por Janaína Nazzari Gomes.
LABORATORY EVALUATION OF THE TOXICITY AND REPELLENCY OF CORIANDER SEED TO FOUR SPECIES OF STORED-PRODUCT INSECTS1
Authors: Su Helen C. F. 
Published: September 2017

Seed and oil of Coriandrum sativum L. (coriander) were evaluated for their contact toxicity to adults of Callosobruchus maculatus (F.), Sitophilus oryzae (L.), Lasioderma serricome (F.), and Tribolium confusum Jacquelin du Val; and for their repellency to S. oryzae and T. confusum. The acetone extract of the seed was topically nontoxic to C. maculatus, slightly toxic to L. serricorne and T. confusum, and moderately toxic to S. oryzae at 40 μg/insect and higher at 48 hr after application. The oil was topically nontoxic to C. maculatus, L. serricome, and T. confusum, and was moderately toxic to S. oryzae at 30 μg/insect and higher.
Both the acetone extract and oil were repellent to S. oryzae when they were used to surface treat the wheat at dosages of 0.2, 0.1, and 0.05%, with the oil slightly more repellent than the extract at the 0.2% concentration. Both the extract and oil repelled T. confusum when the insects were exposed to the surface of the treated paper at concentrations of 600, 400, 200, and 100 μg/cm2, with the extract more effective than the oil
EFFECT OF A STICKER ON THE TOXICITY OF PENNCAP-M® AND FURADAN® TO HONEY BEES1 WHEN THESE INSECTICIDES WERE SPRAYED ON FLOWERING ALFALFA23
Authors: Moffett Joseph O. , Harvey Jack , Cox Robert 
Published: September 2017

Adding an experimental sticker did not markedly reduce the toxicity of either Furadan® (carbofuran) or Penncap-M® (a microencapsulated formulation of methyl parathion) to honey bees. When sprayed on flowering alfalfa, these insecticidal formulations killed large numbers of bees in colonies located on the borders of the sprayed fields.
In a related study, Penncap-M, without the sticker, killed colonies placed adjacent to the treated field 5 hr after this spray was applied. In contrast, colonies placed next to a field 5 hr after it was sprayed with a combination of both the experimental sticker and Penncap-M lost only 11% as many bees as the colonies placed next to the field that was sprayed with only Penncap-M.
In the Furadan-treated fields, the alfalfa foliage had 873 times more carbofuran residue per gram than the honey samples. Freshly collected pollen from pollen traps had 15 times more carbofuran, and dead bees had 6 times more carbofuran than the honey samples.
In the Penncap-M-treated fields, the alfalfa foliage had 356 times more methyl parathion than the dead bee samples. Pollen contained 21 times more parathion per gram than the dead bees. Honey from the Penncap-M-treated fields was not analyzed.
MORTALITY OF TETRANYCHUS URTICAE KOCH (ACARI: TETRANYCHIDAE) FROM ABAMECTIN RESIDUES: EFFECTS OF HOST PLANT, LIGHT, AND SURFACTANTS
Authors: Mizell R. F. , Schiffhauer D. E. , Taylor J. L. 
Published: September 2017

Residues of abamectin (avermectin, Avid), 15 ppm; abamectin + Leaf Act 80, 15 + 25 ppm; abamectin + Sunspray oil, 15 + 25 ppm, and a water control were evaluated for length of control of twospotted spider mite, Tetranychus urticae Koch, on 3 host species: azalea, Rhododendron × ‘Red Ruffle’; lima bean, Phaseolus limensis var. limenus L. H. Bailey cv. ‘Henderson’ bush; and peach, Prunus persica L. Batsch cv. ‘Nemaguard’; and under sunlight and fluorescent light regimes.
Abamectin alone or in combination with the surfactants, 21 days post treatment, resulted in 42.6 – 91.8% and 88 – 93% mite mortality under sunlight and fluorescent light, respectively. No treatments on azalea or peach under sunlight caused &gt; 37% mortality. Treatments caused similar mite mortality 1 day posttreatment under fluorescent light, but after day 1 treatments on peach caused &lt; 62 % mortality while treatments on azalea caused &lt; 46% mortality. The addition of oil increased mite mortality significantly on beans under sunlight at 14 days. At 21 days both Leaf Act 80 and oil increased mite mortality on bean compared to abamectin alone.
REFINEMENT OF A SPRAY TIMING TECHNIQUE FOR THE NANTUCKET PINE TIP MOTH (LEPIDOPTERA: TORTRICIDAE)
Authors: Kudon Louis H. , Berisford C. Wayne , Dalusky Mark J. 
Published: September 2017

Application of dimethoate on various spray dates enabled a refinement of a spray timing technique for control of the third generation of Nantucket pine tip moth. Two spray applications were necessary for adequate control but proper timing of the first application was found to be more critical. Optimal control was achieved when the first spray was applied at 520 degree days after the onset of male moth flight. Optimal dates generally coincided with peak egg densities.
Although a few eggs and early instar larvae were found after the completion of the third generation of tip moth, no extended survival, damage or other indication of a fourth generation was recorded.
LIFE CYCLE AND REPRODUCTION OF RHOPALOSIPHUM PADI (L.) (HOMOPTERA: APHIDIDAE) ON WHEAT IN THE LABORATORY1
Authors: Foster J. E. , Stamenkovic S. S. , Araya J. E. 
Published: September 2017

The life span and reproduction of the bird cherry-oat aphid, Rhopalosiphum padi (L.), was studied in chambers at 25 ± 0.5°C and a 12:12 hr light:dark cycle on winter wheat (Triticum aestivum L. em Thell.) cvs. Blueboy, Monon, Seneca, Knox 62, and Arthur 71, and oats (Avena sativa L.) cv. Clintland 64 (C64). The life cycle, wing formation, fecundity, and longevity of R. padi varied significantly among cultivars.
Apterae and alatae longevity were similar on the same cultivar. Wingless R. padi lived for 24.9–29.6 days on wheat cultivars and 33.1 days on C64 oats. The alatae lived for 26.6–28.3 days on wheats and 33.2 days on C64 oats. Differences in the longevity of alatae were highly significant (P ≤ 0.01) between C64 and the wheats Knox 62 and Seneca, as well as between Blueboy, Arthur 71, and Monon.
On wheat, the reproductive period lasted longer in wingless (24.9–29.6 days) than in winged (26.6–28.3 days) aphids. Clintland 64 oats were the most suitable host for R. padi (apterae and alatae mean progeny of 38.7 nymphs per famale). On wheat, progeny production ranged from 6.4 nymphs on Seneca to 24.0 on Blueboy. The least suitable hosts for R. padi were the Seneca and Know 62 cultivars. These cultivars showed a relative antibiosis type of resistance to the bird cherry-oat aphid. Selections from Seneca and Know 62 may be of use in wheat breeding programs for plant resistance against R. padi.
Feeding Activity of Carabid Beetles and Spiders on Gypsy Moth Larvae (Lepidoptera: Lymantriidae) at High-density Prey Populations2
Authors: DuDevoir Deborah S. , Reeves R. Marcel 
Published: September 2017

Pitfall traps and tree bands were used to collect arthropods at two sites in southeastern New Hampshire during the 1982–83 outbreak of gypsy moth. Pitfall traps caught more individuals (74% of total) than tree bands. Carabid beetles (59%) and spiders (22%) were the dominant groups. Twenty-two genera and 48 species of carabid beetles and 31 genera and 43 species of spiders were collected. Spiders had more species and a larger proportion (38%) collected under tree bands than did carabid beetles (12%).
Guts of all individuals were tested for presence of gypsy moth proteins using ELISA. Fourteen genera and 26 species of carabid beetles tested positive with the highest percent (50%) recorded for Calosoma frigidum Kirby. Twenty-eight genera and 31 species of spiders tested positive with the highest percent (57%) recorded for Haplodrassus bicornis (Emerton). Positive test results were generally higher in tree band collections for species in either group. Positive tests may have been overestimated in the carabid beetles through carrion feeding, and in the spiders because of the extended period required to digest meals.
Tandem Spinal Stenosis
Authors: Overley Samuel C. , Kim Jun S. , Gogel Brooke A. , Merrill Robert K. , Hecht Andrew C. 
Published: September 2017

Background:
Tandem spinal stenosis refers to spinal canal diameter narrowing in at least 2 distinct regions of the spine, most commonly the lumbar and cervical regions. This entity can be an asymptomatic radiographic finding, or it can present with severe myelopathy and lower-extremity symptoms. Tandem spinal stenosis may impact surgeon decision-making when planning either cervical or lumbar spine surgery, and there is currently no consensus in the literature regarding the treatment algorithm for operative intervention.

Methods:
A MEDLINE literature search was performed using PubMed, the Cochrane Database of Systematic Reviews, and Embase from January 1980 to February 2015 using Medical Subject Heading queries for the terms “tandem spinal stenosis,” “cervical stenosis AND lumbar stenosis,” and “concomitant spinal stenosis.” We included studies involving adult patients, tandem spinal stenosis of the cervical and lumbar regions, and a minimum of 5 patients. Articles that did not discuss spinal disorders or only explored disorders at a single spinal region were excluded.

Results:
The initial database review resulted in 234 articles. After abstracts were reviewed, only 17 articles that met inclusion criteria were identified: 2 cadaveric studies, 5 clinical studies of patients with radiographic tandem spinal stenosis, and 10 clinical studies of patients with symptomatic tandem spinal stenosis.

Conclusions:
Tandem spinal stenosis is a common condition present in up to 60% of patients with spinal stenosis. This disorder, however, is often overlooked, which can lead to serious complications. Identification of tandem spinal stenosis is paramount as a first step in management and, although there is still no preferred intervention, both staged and simultaneous procedures have been shown to be effective. Surgeons may utilize a single, staged, or combined approach to decompression, always addressing cervical myelopathy as a priority.
Governance and socio-political issues in management of acid mine drainage in South Africa
Authors: Mpofu Charles , Morodi Thabiso John , Hattingh Johan Petrus 
Published: September 2017

AbstractThe water resources in South Africa are threatened by current and past mining practices such as abandoned and closed mines. While mining is considered valuable for its contribution to this country's gross domestic product, its polluting effects on water and land resources have been criticised as unsustainable. Acid mine drainage (AMD) is one specific public health and ecological issue that has stirred debates in political and social circles in this country. This paper examines the scalar politics and other related dimensions of water and AMD governance, thereby revealing evidence of deep-rooted challenges regarding the governance of water and mineral resources. The specific focus is on the socio-political context of labour laws and Black Economic Empowerment and the decision-making processes adopted by government. Thus, this paper has implications for the improvement of environmental governance and decision-making strategies and the adoption of a national strategy for adequately addressing AMD and related policy issues.
Managerial Ability, Financial Distress, and Audit Fees
Authors: Gul Ferdinand A. , Khedmati Mehdi , Lim Edwin KiaYang , Navissi Farshid 
Published: September 2017

SYNOPSIS
This study examines whether the relationship between managerial ability and audit fees is conditional on financial distress. We find that higher managerial ability increases audit fees in financially distressed firms and decreases audit fees in non-distressed firms. We also observe that financially distressed firms with higher-ability managers display lower accrual quality and a higher likelihood of restatement. Moreover, higher-ability managers in distressed firms engage more in opportunistic financial reporting to concurrently maximize equity-based compensation and cope with debt refinancing pressures, which increases audit risks and results in greater audit fees. We confirm our results using a battery of sensitivity and additional analyses.
Supplier Internal Control Quality and the Duration of Customer-Supplier Relationships
Authors: Bauer Andrew M. , Henderson Darren , Lynch Daniel P. 
Published: September 2017

ABSTRACT
Internal controls influence information quality, thus affecting the ability of supply chain partners, who rely on collaborative systems of information sharing, to reliably contract. Using SOX-related internal control assessments as a proxy for internal control quality and U.S. GAAP-mandated major customer disclosures, we find that supplier internal control quality influences supply chain relationship duration. Specifically, our evidence demonstrates that: (1) poor internal control quality increases the likelihood of subsequent customer-supplier relationship termination; (2) timely control weakness remediation attenuates termination likelihood; and (3) weaknesses affecting customer contracting drive the effect of internal control quality on relationship termination. Our results control for supplier operational quality and performance, and are robust to propensity score matching techniques, controls for reverse causality, and alternative proxies for relationship termination and internal control quality. Overall, our findings are consistent with customers viewing strong supplier controls as important, albeit overlooked, contracting elements with significant implications for supply chain relationships.