bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Beliefs in Human Nature Uniqueness Scale and Its Associations With Perception of Social Robots
Authors: Giger Jean-Christophe , Piçarra Nuno , Pochwatko Grzegorz , Almeida Nuno , Almeida Ana Susana , Costa Neuza 
Published: October 2024

There is an actual trend for humanizing technological artifacts, especially social robots. However, human‐like social robots trigger negative attitudes by threatening human uniqueness as well as humanness. The present paper presents the development of the Belief in Human Nature Uniqueness Scale (BHNUS) to assess the individual tendency to deny social robots the possibility to have human features considered to be the hallmarks of humanness. The validation of the BHNUS was completed along seven studies, with a total of 1044 Portuguese participants. Results showed that BHNUS had good structural qualities (Studies 1 and 2), as well as good convergent and discriminant validities. BHNUS was correlated with negative attitudes towards robots, religiosity, and interest for science fiction (Study 3), attribution of traits of warmth to robots (Study 4), positive and negative emotional appraisal (Study 5), perspective taking (Study 6), and attitudes towards the development of robots with human features (Study 7). The importance of the BHNUS regarding the development of social robots and human–robot interaction is discussed.If you were to insist I was a robot, you might not consider me capable of love in some mystic human sense, but you would not be able to distinguish my reactions from that which you would call love so what difference would it make?Isaac Asimov (1982) in Foundation’s Edge, p. 420
Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis
Authors: Hazelwood Emma , Lopez Manzano Catalina , Vincent Emma E. , Albanes Demetrius , Bishop David Timothy , Le Marchand Loïc , Ulrich Cornelia M. , Peters Ulrike , Murphy Gwen , Samadder Niloy Jewel , Anderson Laura , Gunter Marc J. , Murphy Neil , Van Guelpen Bethany , Papadimitriou Nikos 
Published: October 2024

Abstract

Background:
Epidemiological and laboratory-based studies have provided conflicting evidence for a role of ghrelin in colorectal cancer development. We conducted two-sample Mendelian randomization (MR) analyses to evaluate evidence for an association of circulating ghrelin and colorectal cancer risk overall and by sex, cancer subsite, and age at diagnosis.

Methods:
Genetic instruments proxying plasma total ghrelin levels were obtained from a recent genome-wide association study of 54,219 participants. Summary data for colorectal cancer risk were obtained from a recent meta-analysis of several genetic consortia (up to 73,673 cases and 86,854 controls). A two-sample MR approach and several sensitivity analyses were applied.

Results:
We found no evidence for an association of genetically predicted plasma total ghrelin levels and colorectal cancer risk (0.95, 95% confidence interval, 0.81–1.12; R2 of ghrelin genetic instruments: 4.6%), with similarly null results observed when stratified by sex, anatomical subsite, and for early-onset colorectal cancer.

Conclusions:
Our study suggests that plasma ghrelin levels are unlikely to have a causal relationship with overall, early-onset, and sex- and cancer subsite–stratified colorectal cancer risk.

Impact:
This large-scale analysis adds to the growing body of evidence that plasma total ghrelin levels are not associated with colorectal cancer risk.
Phase II Trial of Gemcitabine and Nab-Paclitaxel for Recurrent Osteosarcoma with Serial Monitoring Using Liquid Biopsy: A Report from the National Pediatric Cancer Foundation
Authors: Dhir Aditi , Hayashi Masanori , Bodlak Avery , Oesterheld Javier , Loeb David M. , Mascarenhas Leo , Isakoff Michael S. , Sandler Eric S. , Borinstein Scott C. , Trucco Matteo , Lagmay Joanne P. , Setty Bhuvana A. , Pratilas Christine A. , Caywood Emi , Metts Jonathan , Yin Hong , Fridley Brooke , Yin Jun , Laborde Jose , Reed Damon R. , Adams Daniel L. , Wagner Lars M. 
Published: October 2024

Abstract

Purpose:
The combination of gemcitabine and docetaxel is often used to treat patients with recurrent osteosarcoma. Nab-paclitaxel has preclinical activity against osteosarcoma and is potentially less myelosuppressive than docetaxel. We conducted a prospective multi-institutional phase II trial combining gemcitabine and nab-paclitaxel for patients aged 12 to 30 years with recurrent osteosarcoma and measurable disease.

Patients and Methods:
A Simon’s two-stage design was used to test a 4-month progression-free survival (PFS-4) of 10% vs. 35%. Patients received nab-paclitaxel 125 mg/m2 and gemcitabine 1,000 mg/m2 weekly × 3 in 4-week cycles. Immunohistochemical analysis of archival tissue and serial assessment of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) using ultralow passage whole-genome sequencing were performed to identify potential biomarkers of response.

Results:
Eighteen patients received 56 total cycles (median 2, range 1–12). Two patients (11%) experienced confirmed partial response and six (33%) received &gt;2 cycles. The PFS-4 was 28% (95% confidence interval, 13%–59%). Six patients required dose reductions and three patients were removed due to toxicities. All 18 patients had detectable CTCs and 10 had ctDNA identified. All eight patients with MYC amplification at study entry experienced disease progression.

Conclusions:
Gemcitabine and nab-paclitaxel demonstrated similar clinical activity and toxicity compared to previous retrospective reports utilizing gemcitabine and docetaxel in patients with recurrent osteosarcoma. Serial analysis of CTC and ctDNA was feasible in this prospective multi-institution study and provides preliminary data on the use of these assays in patients with relapsed disease.
CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment
Authors: Lee Jihui , Goeckel Megan E. , Levitas Allison , Colijn Sarah , Shin Jimann , Hindes Anna , Mun Geonyoung , Burton Zarek , Chintalapati Bharadwaj , Yin Ying , Abello Javier , Solnica-Krezel Lilianna , Stratman Amber N. 
Published: October 2024

BACKGROUND:
Endothelial cell (EC)–pericyte interactions are known to remodel in response to hemodynamic forces; yet there is a lack of mechanistic understanding of the signaling pathways that underlie these events. Here, we have identified a novel signaling network regulated by blood flow in ECs—the chemokine receptor CXCR3 (CXC motif chemokine receptor 3) and one of its ligands, CXCL11 (CXC motif chemokine ligand 11)—that delimits EC angiogenic potential and promotes pericyte recruitment to ECs during development.

METHODS:
We investigated the role of CXCR3 on vascular development using both 2- and 3-dimensional in vitro assays, to study EC-pericyte interactions and EC behavioral responses to blood flow. Additionally, genetic mutants and pharmacological modulators were used in zebrafish in vivo to study the impacts of CXCR3 loss and gain of function on vascular development.

RESULTS:

In vitro modeling of EC-pericyte interactions demonstrates that suppression of EC-specific CXCR3 signaling leads to loss of pericyte association with EC tubes. In vivo, phenotypic defects are particularly noted in the cranial vasculature, where we see a loss of pericyte association with ECs and expansion of the vasculature in zebrafish treated with the Cxcr3 inhibitor AMG487 or in homozygous
cxcr3.1/3.2/3.3
triple mutants. We also demonstrate that CXCR3-deficient ECs are more elongated, move more slowly, and have impaired EC-EC junctions compared with their control counterparts.

CONCLUSIONS:
Our results suggest that CXCR3 signaling in ECs helps promote vascular stabilization events during development by preventing EC overgrowth and promoting pericyte recruitment.
The Index of Countries’ Support for UN-based Multilateralism: Construction, Verification,  and Correlates
Authors: Lafortune Guillaume , Sachs Jeffrey D. 
Published: October 2024

Abstract
Global cooperation and a strong United Nations (UN) system are needed to implement shared global goals such as the Paris Climate Agreement and the Sustainable Development Goals. For the first time, we present a new index of Nation-States’ support for UN-based multilateralism (UN-Mi) based on the principles established in the UN Charter in 1945. We use six headline indicators and follow best practices to verify the statistical validity and robustness of our construct. Our findings suggest that there are significant differences in countries’ support for UN-based multilateralism. Some large economic powers showcase low and declining support for UN-based multilateralism. The poor performance of the United States and some of its allies suggests that the concepts of “Rules-Based-International Order” and “UN-based multilateralism” are truly distinct, and arguably, even opposite, frameworks. Our statistical analysis confirms that the UN-Mi captures something different than other existing constructs that aim to capture, for instance, the size of diplomatic networks or people's confidence in the UN.
The Gender Wage Gap in Cambodia
Authors: Oum Sothea , Cheng Savuth 
Published: October 2024

Abstract
Over the past decade, Cambodia has enjoyed robust economic growth as well as notable improvements in socioeconomic development, including a decline in poverty and improvements in education and health. However, women continue to earn less than men at the headline level. This paper uses the latest available data (2014, 2017, and 2019) and examines changes in the trends in wage gap from 2014 and 2019 and its underlying contributors. Like previous studies, results presented in this paper point to unobservable factors, most likely including gender discrimination, as the primary contributors fueling the labor market's gender wage gap. This study also finds some improvements in gender gap reduction attributable to observable factors from 2014 to 2019, including improvements in bridging the gender gaps in education, types of occupation, industry, and workplace. These findings reinforce the call for policy measures aimed at further reducing the gender gap.
Decolonizing Diets: Idol Food, Jewish Diaspora, and the Crisis of John’s Apocalypse
Authors: Mata Roberto 
Published: October 2024

Abstract
This article explores how Revelation’s Jewish Diaspora negotiated the Roman colonial situation of Asia Minor through their stance on idol food. Scholars have suggested that John wrote to Christians suffering imperial persecution under Domitian. Still, others have proposed a perceived crisis, a prophetic rivalry relating to Greco-Roman society, or a summons to a holy war. However, some of these mostly depoliticizing trends presuppose the so-called partying of the ways and neglect to explore the centrality of ritual food and its association with Roman imperial authority. Drawing on Frantz Fanon’s analysis of colonial situations and sociological notions of food and eating, I map how John and the inscribed Jewish Diaspora communities of Revelation turned idol food into a locus for negotiating Roman colonial authority in Asia Minor circa 100 C.E.
A Satirical Pythagoras?
Authors: Spalic Clara 
Published: October 2024

Abstract
This paper aims at exploring the presence of humor in the Pythagoras episode (Met. 15.60-478), and, hence, proposing parallels between Pythagoras’ speech and Horace’s S. 2.4, analyzing the Ovidian manipulation of this satirical model and the interpretative possibilities suggested by this perspective.
The Conditionality of Helenus’ Oracle and Tragic Choice in Sophocles’ Philoctetes
Authors: McPhee Brian D. 
Published: October 2024

Abstract
Helenus’ oracle in Sophocles’ Philoctetes is commonly misunderstood as an unqualified revelation of an immutable future: the gods have fated Philoctetes to rejoin the Greek army at Troy. This has occasioned further misinterpretations of the play, especially as regards the “false ending”, in which Neoptolemus and Philoctetes would appear to disregard the divine will in an act of conscious impiety by choosing to sail for Malis instead. This paper argues that the oracle should rather be understood as conditional, allowing Philoctetes either to assent or refuse to rejoin the Greek army in good conscience. In the absence of compulsion from the gods, Neoptolemus and Philoctetes feel free to make tragic choices of real gravity about their futures, and these choices reveal the duo’s characters before Heracles appears and reverses their course.
Effect of combined aerobic-resistance training on regulating adipokine levels among obese females
Authors: Sugiharto  , Rejeki P.S. , Lesmana R. , Merawati D. , Susanto H. , Taufiq A. , Widyatama F.S. , Amelia D. , Pranoto A. 
Published: October 2024

Abstract
Physical training is a beneficial strategy to regulate adipokines in preventing obesity and metabolic syndrome. However, effective training remains to be an intriguing topic of debate. Therefore, this study aims to investigate the effect of aerobic training, resistance training, and combined aerobic-resistance training on adipokines using the hormone biomarkers (leptin and adiponectin). Our research subjects were 32 obese females aged 22 years old with a body fat percentage ≥ 30%. Subjects were divided into four groups, namely the CTL (n = 8; control group), ATr (n = 8; aerobic training group), RTr (n = 8; resistance training group), and CTr (n = 8; combined training group). Training was carried out for eight weeks, with frequency 3×/week and moderate intensity. Aerobic training was performed by running on a treadmill with an intensity of 65-70% HRmax for 45 min. Meanwhile, resistance training was completed with 65-70% 1-RM intensity for six sets @15 reps and active resting of 30 s between sets. Further, the blood sampling for leptin and adiponectin examination was carried out pre- and post-training, while its examination was carried out using the ELISA method. The results indicated significantly lower leptin levels and higher adiponectin pre- and post-training in ATr, RTr, and CTr (), but not in CTL (). Besides, we also observed decreasing Δ-leptin at CTL, ATr, RTr, and CTr were 37.42 ± 44.29, −206.16 ± 43.73, −139.49 ± 69.11, and −349.07 ± 71.69 pg/ml, respectively (). Likewise increasing Δ-adiponectin between CTL, ATr, RTr, and CTr were 90.89 ± 212.70, 679.16 ± 136.29, 619.77 ± 168.37, and 872.04 ± 335.73 pg/ml, respectively (). It was concluded that aerobic-resistance combined training has been proven effective in reducing leptin and increasing adiponectin compared to aerobic training and resistance training, therefore it was recommended to use aerobic-resistance combined training in improving adipokines in obese.
Comparing health-related quality of life and utility scores of patients undergoing hemodialysis and continuous ambulatory peritoneal dialysis in Indonesia
Authors: Rokhman M Rifqi , Wardhani Yulia , Partiningrum Dwi Lestari , Purwanto Barkah Djaka , Hidayati Ika Ratna , Idha Arofa , At Thobari Jarir , Postma Maarten J , Boersma Cornelis , van der Schans Jurjen 
Published: October 2024

Background Although both hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) are covered by national healthcare insurance, 98% of kidney failure disease patients are treated with hemodialysis. This study compared the health-related quality of life (HRQoL) and utility scores of patients receiving hemodialysis and CAPD in Indonesia and determined factors associated with HRQoL and utility scores. Methods A cross-sectional study was performed using the Kidney Disease Quality of Life-36 and EQ-5D-5L instruments at six hospitals. Utility scores were presented as SF-6D and EQ-5D scores. Factors associated with the EQ-5D were evaluated using Tobit regressions due to ceiling effects, while the SF-6D and HRQoL were assessed using generalized linear models since the data were not normally distributed. Results Among the 613 patients, 76% were treated with hemodialysis. After adjusting for sociodemographic characteristics and clinical parameters, CAPD patients reported better HRQoL compared to hemodialysis patients in terms of the SF-6D ( p = .038), mental component summary ( p = .020), symptoms ( p = .005), and effects of kidney disease ( p<.001), but no significant differences were reported in EQ-5D ( p = .083), physical component summary ( p = .323), burden of kidney disease ( p = .111), and kidney summary scores ( p = .068). Poorer HRQoL and utility scores were likely experienced by older patients who were male, married, with diabetes, treated in Class A hospitals, and with lower education, hemoglobin, and albumin levels. Conclusion In Indonesia, patients treated with CAPD had better HRQoL and utility scores compared to patients undergoing hemodialysis. Therefore, CAPD should be promoted by healthcare professionals as the first treatment option for patients who are eligible for both hemodialysis and CAPD.
Reliability of Variables of Consonant Production and Velopharyngeal Competence in 10-year-olds with Cleft Palate Using Multiple Raters
Authors: Klintö Kristina , Schaar Johansson Malin , Andersson Magdalena , Gällstedt Caroline , Lindberg Cecilia , Nelli Cecilia , Okhiria Åsa 
Published: October 2024

Objective To assess the reliability of speech data and speech-related quality indicators in the Swedish quality registry for cleft lip and palate (CLP) at 10 years of age. Design Retrospective study. Setting University hospitals. Participants One hundred twenty-one 10-year-olds with unilateral or bilateral CLP. Main outcome measures Six independent raters reassessed audio recordings for comparison with registry data. For calculation of agreement, the single measures intraclass correlation coefficient (ICC) was used for percentage of consonants correct (PCC) and non-oral speech errors, quadratic weighted kappa for velopharyngeal competence (VPC), and percentage agreement and kappa for quality indicators. The results of the three to four raters with the highest intra-rater and inter-rater reliability were used for comparison with registry data. Results There was excellent agreement between registry data and reassessments for PCC (ICC, 0.93) and percentage of non-oral errors (ICC, 0.80). For VPC, one rater and registry data had good agreement (k, 0.704); the remaining cases had fair agreement (k, 0.476-0.554). The percentage agreement between registry data and reassessments for quality indicators ranged from fair to excellent. When calculated with kappa, agreement was good to excellent (mean of all k values, 0.67-0.70). Conclusions The CLP registry variables PCC and percentage of non-oral errors and the quality indicators without non-oral speech errors and competent/marginally incompetent velopharyngeal function are reliable for use in clinical audits and research of 10-year-olds. The three-tier ratings of VPC have weaker reliability but can still be useful in more detailed analyses if interpreted with caution.
Automatic Landmark Annotation and Measurement of 3D Mandibular Morphology Using Non-Rigid Registration: A Preliminary Exploration and Accuracy Assessment
Authors: Chen Zhewei , Lei Bowen , Li Binghang , Ma Hengyuan , Zhong Yehong 
Published: October 2024

This study aimed to develop an automatic methodology for mandibular landmarking and measurement using non-rigid registration as well as analyze the accuracy of automatic landmarking and measurements. Statistical analysis. Digital technology center, tertiary hospital. 130 healthy Chinese adults with equal gender distribution, average age 28.2 ± 5.6 years. Four mean shape mesh templates were generated from 100 head CT scans. Following manual indication of landmarks, these templates were applied for automatic landmark annotation and measurements on mandibles from another 30 head CT scans, using non-rigid iterative closest point registration. Differences of landmark coordinates and measurements between automatic and manual annotation were analyzed using mean difference, centroid size, Euclidean distances and intraclass correlation coefficient (ICC), assessing the accuracy and validity of automatic landmark annotation. The majority of automatic landmarks (16/22) did not exhibit consistent displacement to specific direction. ICCs of all landmark coordinates exceed 0.950, with 87.9% larger than 0.990. The average Euclidean distance between manual and automatic landmarks was 2.038 ± 0.947 mm. Most ICCs of linear and angular measurements between manual and automatic annotation (20/26) exceeded 0.900, with the average errors being 1.425 ± 0.973 mm and 2.257 ± 0.649 °, respectively. A novel and efficient method for automatic landmark annotation was established based on non-rigid registration. Its credibility and accuracy in mandibular annotation and measurements were demonstrated.
Exclusion of ranitidine from premedication regimen during paclitaxel treatment: A retrospective single-center analysis
Authors: Iglesias-Santamaría Araceli 
Published: October 2024

Introduction To minimize the risk of hypersensitivity reactions (HSRs) caused by paclitaxel infusion, premedication with corticosteroid, H1-antagonist and H2 antagonist (ranitidine) was standard of care. Discontinuation of ranitidine in 2020 led to adjustments in premedication regimens and a new regimen without ranitidine was implemented in our center. This study aimed to compare the incidence of HSRs during paclitaxel treatment of a standard premedication regimen including ranitidine with a new premedication regimen without ranitidine and with a titrated infusion rate during the first two administrations. Methods Retrospective data analysis was performed on two cohorts of adult patients with solid tumors who started treatment with paclitaxel and received a premedication regimen with and without ranitidine over the years 2021 and 2023 respectively (before and after ranitidine withdrawal). Univariable and multivariable logistic regression models were used to investigate any associations with H2 antagonist treatment adjusting for confounding variables. Results A total of 319 patients were included. 158 patients received the standard premedication regimen with ranitidine compared to 161 patients who did not received ranitidine. HSRs were observed in 10 of 1101 administrations of paclitaxel (0,90%) in ranitidine group compared to 2 of 899 (0,22%) in the ranitidine-free cohort (p = 0.048). Analysis incidence per patient also found results with statistically significant differences: 5.7% (9 of 158 patients) in the ranitidine cohort compared to 1.2% (2 of 161 patients) in the ranitidine-free cohort (p = 0.029). Conclusions The results of the study show the effectiveness of a premedication regimen including only dexchlorpherinamine and dexamethasone, along with a titrated infusion rate during the first two administrations, in reducing the incidence of paclitaxed-induced HSRs.