bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boys have not caught up, family influences still continue: Influences on executive functioning and behavioral self‐regulation in elementary students in Germany
Authors: Gunzenhauser Catherine , Saalbach Henrik , von Suchodoletz Antje 
Published: September 2017

AbstractThe development of self‐regulation is influenced by various child‐level and family‐level characteristics. Previous research focusing on the preschool period reported a female advantage in self‐regulation and negative effects of various adverse features of the family environment on self‐regulation. The present study aimed to investigate growth in self‐regulation (i.e., executive functioning and behavioral self‐regulation) over 1 school year during early elementary school and to explore the influences of child sex, the level of home chaos, and family educational resources on self‐regulation. Participants were 263 German children (51% girls; mean age 8.59 years, SD = 0.56 years). Data were collected during the fall and spring of the school year. A computer‐based standardized test battery was used to assess executive functioning. Caregiver ratings assessed children's behavioral self‐regulation and information on the family's home environment (chaotic home environment and educational resources). Results suggest growth in elementary school children's executive functioning over the course of the school year. However, there were no significant changes in children's behavioral self‐regulation between the beginning and the end of Grade 3. Sex differences in inhibitory control/cognitive flexibility and behavioral self‐regulation were found, suggesting an advantage for girls. Educational resources in the family but not chaotic family environment were significantly related to self‐regulation at both time‐points. Children from families with more educational resources scored higher on self‐regulation measures compared to their counterparts from less advantaged families. We did not find evidence for child‐level or family‐level characteristics predicting self‐regulation growth over time. Findings add to the evidence of a gender gap in self‐regulation skills, but suggest that it might not further widen towards the end of elementary school age. Adequate self‐regulation skills should be fostered in both girls and boys. Results also add to the importance of supporting self‐regulation development in children from disadvantaged family backgrounds early in life.
A novel polymer‐based genosensor for the detection and quantification of Streptococcus pneumoniae in genomic DNA sample
Authors: Ferreira Fábio P. , Honorato‐Castro Ana C. , da Silva Jussara Vieira , Orellana Sara‐Cuadros , Oliveira Guilherme C. , Madurro João M. , Brito‐Madurro Ana G. 
Published: September 2017

The Streptococcus pneumoniae detection plays an important role in the diagnosis and monitoring of pneumococcal diseases. A genosensor based on graphite electrodes modified with polymer was developed for such detection. First, the poly(4‐aminophenol) film was electrochemically deposited on a graphite electrode. Afterward, an S. pneumoniae‐specific oligonucleotide (Strep1), isolated from conserved regions of the bacterial genome, was immobilized onto the modified electrode surface and used for the test with complementary target oligonucleotide (Strep2) or genomic DNA. The genosensor was evaluated using electrochemical techniques and atomic force microscopy. Poly(4‐aminophenol) film caused an increase in probe immobilization, monitoring the guanine oxidation peak. The detection limits obtained using differential pulse voltammetry and electrochemical spectroscopy impedance were 54 and 28 ng mL−1, respectively. The novel genosensor was efficient for the immobilization and detection of S. pneumoniae genomic DNA. POLYM. ENG. SCI., 58:1308–1314, 2018. © 2017 Society of Plastics Engineers
Clustal Omega for making accurate alignments of many protein sequences
Authors: Sievers Fabian , Higgins Desmond G. 
Published: September 2017

AbstractClustal Omega is a widely used package for carrying out multiple sequence alignment. Here, we describe some recent additions to the package and benchmark some alternative ways of making alignments. These benchmarks are based on protein structure comparisons or predictions and include a recently described method based on secondary structure prediction. In general, Clustal Omega is fast enough to make very large alignments and the accuracy of protein alignments is high when compared to alternative packages. The package is freely available as executables or source code from www.clustal.org or can be run on‐line from a variety of sites, especially the EBI www.ebi.ac.uk.
Phosphopeptide enrichment with cross‐linked Os(II)(dmebpy)2Cl‐derivatized acrylamide and vinylimidazole copolymer
Authors: Zhou Jie 
Published: September 2017

RationaleReversible phosphorylation of proteins catalyzed by kinases and phosphatases plays a key regulatory role in intracellular biological processes. Protein phosphorylation profiling is still a challenge due to its low stoichiometry, diversity of phosphorylated protein forms, and dynamic nature of phosphorylation states. Mass spectrometry (MS) has been widely used for the characterization of protein phosphorylation, due to its high sensitivity and MS/MS sequencing capability. However, the low abundance and ionization efficiency of phosphorylated peptides and interference from their non‐phosphorylated counterparts and other peptides in the enzymatic digests of proteins complicate the localization of phosphorylation sites in liquid chromatography (LC)/MS analysis. So the enrichment of phosphopeptides from the digests is often required before LC/MS. Immobilized metal affinity chromatography (IMAC) and metal oxide affinity chromatography (MOAC) are the two most commonly used enrichment techniques for phosphopeptides prior to MS analysis.MethodsCross‐linked Os(II)(4,4’‐dimethyl‐2,2’‐bipyridine)2Cl‐derivatized acrylamide and vinylimidazole copolymer were applied for the enrichment of phosphopeptides.ResultsUnder neutral loading buffer conditions phosphopeptides bind on the Os‐polymer without nonspecific binding of acidic peptides. Differential binding of monophosphorylated and multiply phosphorylated peptides can be achieved under different concentrations of imidazole. Sequential elution of bound phosphopeptides can be obtained with elution buffers of different pH values below 3. The loading buffers with imidazole can be aqueous or 7/3 H2O/ACN. Once phosphopeptides bind onto the Os‐polymer, washing with water, 0.1% acetic acid (pH ~ 3) or 1/1 H2O/ACN 0.05% acetic acid (pH ~3) does not elute phosphopeptides. The Os‐polymer does not show bias of binding and elution toward phosphopeptide standards with singly, doubly and triply phosphorylated sites.ConclusionsCross‐linked Os(II)(dimethylbipyridine)2Cl‐derivatized poly(acrylamide)‐poly(vinylimidazole) copolymer is proven to be a new efficient IMAC resin for phosphopeptide enrichment and shows some unique properties for differential binding and sequential elution of phosphopeptides. It could become a better alternative to traditional IMAC and TiO2 for phosphopeptide enrichment.
Asymptotic stability in probability for discrete‐time stochastic coupled systems on networks with multiple dispersal
Authors: Wang Pengfei , Hong Yu , Su Huan 
Published: September 2017

SummaryIn this paper, we consider the asymptotic stability in probability for discrete‐time stochastic coupled systems on networks with multiple dispersal (DSCSM). We begin with modeling a DSCSM on multiple digraphs and consequently construct a global Lyapunov function based on the topological structure of multiple digraphs. Using the Lyapunov method combined with the graph theory and the supermartingale convergence theorem, several stability criteria for DSCSM are derived. In what follows, the given results are utilized to analyze a stochastic coupled oscillator model. Finally, 2 numerical examples are also given to demonstrate the feasibility of the proposed results.
Can macroinvertebrate biological traits indicate fine‐grained sediment conditions in streams?
Authors: Murphy J. F. , Jones J. I. , Arnold A. , Duerdoth C. P. , Pretty J. L. , Naden P. S. , Sear D. A. , Collins A. L. 
Published: September 2017

AbstractExcessive inputs of fine‐grained sediment can damage aquatic ecosystems both by degrading habitat condition and by directly impairing biota. Recent research has improved our understanding of how benthic macroinvertebrates respond to fine‐grained sediment stress, leading to the development of a variety of bioassessment indices based on changes in taxonomic composition and biological trait composition. Use of biological traits as indicators of stress has been advocated on the basis of a better mechanistic understanding of the biotic and abiotic factors acting on benthic communities. We quantified changes in the macroinvertebrate biological trait assemblage from a large number of river reaches spanning a national‐scale gradient of increasing agricultural fine sediment delivery and retention, having first factored out variation associated with the natural environmental gradient, with the aim of robustly testing predictions of trait response. We found strong support for 2 of 18 predictions of how macroinvertebrate traits would respond to fine sediment stress. Furthermore, using an independent dataset, we were able to confirm the response of 5 of 6 trait classes that partial RLQ‐fourth corner analysis found to be significantly associated with the fine sediment gradient. Prevalence of eggs as a resistant form, in combination with either an adult aquatic life stage or crawling, provided the best indication of fine sediment conditions in streams, approaching the performance of taxonomic composition‐based sediment indices, CoFSIsp and EPSImtl. This study has robustly confirmed the potential of macroinvertebrate biological traits as indicators of fine sediment impacts.
Static analysis and process model transformation for an advanced business process to Petri net mapping
Authors: Heinze Thomas S. , Amme Wolfram , Moser Simon 
Published: September 2017

SummaryVerification of business processes typically relies on Petri net–based process models. While they allow for natural modeling and analysis of aspects such as parallelism and message exchange, such a process model is seldom complete and precise. This is mainly because the available techniques for deriving a Petri net model from the original model neglect process data in favor of feasible verification. In this paper, we present an approach for deriving more precise process models by leveraging a process‐to‐Petri‐net compiler, which takes as input a business process and generates as output a Petri net model for the process. This can be subsequently used for verification. However, in contrast to a conventional compiler, our compiler's objective is not to create the most efficient code but rather to produce a most precise but still effectively verifiable Petri net–based process model.
CRISPR/Cpf1 enables fast and simple genome editing of Saccharomyces cerevisiae
Authors: Verwaal René , Buiting‐Wiessenhaan Nathalie , Dalhuijsen Sacha , Roubos Johannes A. 
Published: September 2017

AbstractCpf1 represents a novel single RNA‐guided CRISPR/Cas endonuclease system suitable for genome editing with distinct features compared with Cas9. We demonstrate the functionality of three Cpf1 orthologues – Acidaminococcus spp. BV3L6 (AsCpf1), Lachnospiraceae bacterium ND2006 (LbCpf1) and Francisella novicida U112 (FnCpf1) – for genome editing of Saccharomyces cerevisiae. These Cpf1‐based systems enable fast and reliable introduction of donor DNA on the genome using a two‐plasmid‐based editing approach together with linear donor DNA. LbCpf1 and FnCpf1 displayed editing efficiencies comparable with the CRISPR/Cas9 system, whereas AsCpf1 editing efficiency was lower. Further characterization showed that AsCpf1 and LbCpf1 displayed a preference for their cognate crRNA, while FnCpf1‐mediated editing with similar efficiencies was observed using non‐cognate crRNAs of AsCpf1 and LbCpf1. In addition, multiplex genome editing using a single LbCpf1 crRNA array is shown to be functional in yeast. This work demonstrates that Cpf1 broadens the genome editing toolbox available for Saccharomyces cerevisiae. © 2017 The Authors. Yeast published by John Wiley & Sons, Ltd.
Association Between Opioid Use and Risk of Erectile Dysfunction: A Systematic Review and Meta-Analysis
Authors: Zhao Shankun , Deng Tuo , Luo Lianmin , Wang Jiamin , Li Ermao , Liu Luhao , Li Futian , Luo Jintai , Zhao Zhigang 
Published: September 2017

Abstract

Background
Opioid analgesics have been widely used to relieve chronic pain conditions; however, a connection between opioid analgesic administration and increased susceptibility to erectile dysfunction (ED) has been hypothesized.

Aim
To evaluate whether opioid use was a risk factor for ED in a systematic review and meta-analysis.

Methods
The PubMed, Cochrane Library, and Embase databases were searched to identify eligible studies concerning opioid use and risk of ED from inception to April 2017. The association between opioid use and risk of ED was summarized using the relative risk with 95% CI. Sensitivity analyses were conducted to assess potential bias. The Begg and Egger tests were used for publication bias analysis. The GRADE evidence profile tool was used to assess the quality of the evidence.

Outcomes
The overall combined risk estimates for the effect of opioid use on ED were calculated using a random-effects model.

Results
This meta-analysis included 8,829 men (mean age = 41.6 years) from 10 studies, 2,456 of whom received opioid management (duration of intervention = 4 months to 9.5 years). Pooled results demonstrated that the use of opioids was significantly associated with an increased risk of ED (relative risk = 1.96, 95% CI = 1.66–2.32, P &lt; .001). Estimates of the total effects were generally consistent in the sensitivity analysis. No evidence of publication bias was observed. The overall quality of evidence was rated as low.

Clinical Implications
We found that men with opioid use had a significantly increased prevalence of ED, which suggests that patients and clinicians should be aware of the potential role played by opioid administration in the development of ED.

Strengths and Limitations
This is the first meta-analysis performed to describe the relation between opioid use and ED risk based on all available epidemiologic studies. However, the direction of causality between opioid use and risk of ED should be interpreted with caution because most included studies used a cross-sectional design.

Conclusion
Evidence from the included observational studies indicated that men with opioid use had a significantly increased risk of ED. Further randomized controlled trials are still needed to confirm this relation.
Successive enlargement of filtrations and application to insider information
Authors: Blanchet-Scalliet Christophette , Hillairet Caroline , Jiao Ying 
Published: September 2017

Abstract
We model in a dynamic way an insider's private information flow which is successively augmented by a family of initial enlargement of filtrations. According to the a priori available information, we propose several density hypotheses which are presented in hierarchical order from the weakest to the strongest. We compare these hypotheses, in particular, with Jacod's one, and deduce conditional expectations under each of them by providing consistent expressions with respect to the common reference filtration. Finally, this framework is applied to a default model with insider information on the default threshold and some numerical illustrations are performed.
On a random search tree: asymptotic enumeration of vertices by distance from leaves
Authors: Bóna Miklós , Pittel Boris 
Published: September 2017

Abstract
A random binary search tree grown from the uniformly random permutation of [n] is studied. We analyze the exact and asymptotic counts of vertices by rank, the distance from the set of leaves. The asymptotic fraction ck of vertices of a fixed rank k ≥ 0 is shown to decay exponentially with k. We prove that the ranks of the uniformly random, fixed size sample of vertices are asymptotically independent, each having the distribution {ck}. Notoriously hard to compute, the exact fractions ck have been determined for k ≤ 3 only. We present a shortcut enabling us to compute c4 and c5 as well; both are ratios of enormous integers, the denominator of c5 being 274 digits long. Prompted by the data, we prove that, in sharp contrast, the largest prime divisor of the denominator of ck is at most 2k+1 + 1. We conjecture that, in fact, the prime divisors of every denominator for k > 1 form a single interval, from 2 to the largest prime not exceeding 2k+1 + 1.
AUTOMORPHISM GROUPS OF RANDOMIZED STRUCTURES
Authors: IBARLUCÍA TOMÁS 
Published: September 2017

AbstractWe study automorphism groups of randomizations of separable structures, with focus on the ℵ0-categorical case. We give a description of the automorphism group of the Borel randomization in terms of the group of the original structure. In the ℵ0-categorical context, this provides a new source of Roelcke precompact Polish groups, and we describe the associated Roelcke compactifications. This allows us also to recover and generalize preservation results of stable and NIP formulas previously established in the literature, via a Banach-theoretic translation. Finally, we study and classify the separable models of the theory of beautiful pairs of randomizations, showing in particular that this theory is never ℵ0-categorical (except in basic cases).
DEFINABLE TOPOLOGICAL DYNAMICS
Authors: KRUPIŃSKI KRZYSZTOF 
Published: September 2017

AbstractFor a groupGdefinable in a first order structureMwe develop basic topological dynamics in the category of definableG-flows. In particular, we give a description of the universal definableG-ambit and of the semigroup operation on it. We find a natural epimorphism from the Ellis group of this flow to the definable Bohr compactification ofG, that is to the quotient${G^{\rm{*}}}/G_M^{{\rm{*}}00}$(whereG* is the interpretation ofGin a monster model). More generally, we obtain these results locally, i.e., in the category of Δ-definableG-flows for any fixed set Δ of formulas of an appropriate form. In particular, we define local connected components$G_{{\rm{\Delta }},M}^{{\rm{*}}00}$and$G_{{\rm{\Delta }},M}^{{\rm{*}}000}$, and show that${G^{\rm{*}}}/G_{{\rm{\Delta }},M}^{{\rm{*}}00}$is the Δ-definable Bohr compactification ofG. We also note that some deeper arguments from [14] can be adapted to our context, showing for example that our epimorphism from the Ellis group to the Δ-definable Bohr compactification factors naturally yielding a continuous epimorphism from the Δ-definable generalized Bohr compactification to the Δ-definable Bohr compactification ofG. Finally, we propose to view certain topological-dynamic and model-theoretic invariants as Polish structures which leads to some observations and questions.
RETRACTED – MEASURING CLUB-SEQUENCES TOGETHER WITH THE CONTINUUM LARGE
Authors: ASPERÓ DAVID , MOTA MIGUEL ANGEL 
Published: September 2017

AbstractMeasuring says that for every sequence
${\left( {{C_\delta }} \right)_{\delta < {\omega _1}}}$
with each
${C_\delta }$
being a closed subset of δ there is a club
$C \subseteq {\omega _1}$
such that for every
$\delta \in C$
, a tail of
$C\mathop \cap \nolimits \delta$
is either contained in or disjoint from
${C_\delta }$
. We answer a question of Justin Moore by building a forcing extension satisfying measuring together with
${2^{{\aleph _0}}} > {\aleph _2}$
. The construction works over any model of ZFC + CH and can be described as a finite support forcing iteration with systems of countable structures as side conditions and with symmetry constraints imposed on its initial segments. One interesting feature of this iteration is that it adds dominating functions
$f:{\omega _1} \to {\omega _1}$
mod. countable at each stage.
Civilisations and harm: the politics of civilising processes between the West and the non-West
Authors: Chong Alan 
Published: September 2017

AbstractAndrew Linklater’sViolence and Civilization in the Western States-Systemis to be both praised and critiqued for opening spaces for discussing civilisational standards in the era of a globalising world. It offers a healthy provocation for inquiry into how non-Western states ought to comprehend the legacies of Western political evolution colouring existing ‘IR’ as a discipline. Linklater’s book inspires three thematic reactions: globalisation does bring harm; the notion of a universal civilisation remains open to debate; and the possibilities of civilising patterns in premodern Southeast Asia serving as supplementary mirrors and extensions of the relationship between violence and civilisation. It is suggested that Linklater’s sequel must consider the trajectory of non-Western sociologies of IR.
CALL from an ecological perspective: How a teacher perceives affordance and fosters learner agency in a technology-mediated language classroom
Authors: Liu Qian , Chao Chin-Chi 
Published: September 2017

AbstractThe possibility of exploiting technology for more robust and meaningful learning and teaching has invoked messianic responses from the language education community. Yet to be explored are teachers’ pedagogical choices based on the perceived technological affordances as well as interactions between teacher and student agency mediated by these affordances in the ecology of a classroom. This qualitative case study adopts an ecological approach, aiming to address rather than factor out the broader social context in a physical classroom. With data collected from 30 hours of classroom observation and 10 post-observation interviews with the participant teacher, the study makes an attempt to show how the ecological model of language learning can provide a theoretical lens through which to explore teachers’ practices of CALL that aim to encourage learner agency. The analysis centers on three focused extracts that illustrate interaction between and among the affordance of technology, the teacher participant’s pedagogical considerations, and her goal of encouraging learner agency. The result of the study emphasizes the teacher’s role from an ecological perspective and classroom learner agency mediated by technology, which provides useful insight that can contribute to language teaching practice with technology in the classroom.
Secondary acute lymphoblastic leukemia is a distinct clinical entity with prognostic significance
Authors: Rosenberg A S , Brunson A , Paulus J K , Tuscano J , Wun T , Keegan T H M , Jonas B A 
Published: September 2017

AbstractThe effect of prior malignancy on the risk of developing, and prognosis of, acute lymphoblastic leukemia (ALL) is unknown. This observational study utilized the California Cancer Registry to estimate the risk of developing ALL after a prior malignancy using standardized incidence ratios (SIRs, 95% confidence intervals). ALL occurring after a malignancy with an SIR>1 (increased-risk (IR) malignancies) was considered secondary ALL (s-ALL). Adjusted hazard ratios (aHRs, 95% confidence intervals) compared the effect of s-ALL with de novo ALL on overall survival. A total of 14 481 patients with ALL were identified (1988–2012) and 382 (3%) had a known prior malignancy. Any prior malignancy predisposed patients to developing ALL: SIR 1.62 (1.45–1.79). Hematologic malignancies (SIR 5.57, 4.38–6.98) and IR-solid tumors (SIR 2.11, 1.73–2.54) increased the risk of developing ALL. s-ALL increased the risk of death compared with de novo ALL (aHR 1.38 (1.16–1.63)) and this effect was more pronounced among younger patients (age<40 years: aHR 4.80 (3.15–7.30); age⩾40 years: aHR 1.40 (1.16–1.69)) (interaction P<0.001). This population-based study demonstrates that s-ALL is a distinct entity that occurs after specific malignancies and carries a poor prognosis compared with de novo ALL, particularly among patients <40 years of age.