bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival among patients cured from gastric adenocarcinoma compared to the background population
Authors: Leijonmarck Wilhelm , Mattsson Fredrik , Lagergren Jesper 
Published: September 2024

Abstract
Background
It is unknown if gastric adenocarcinoma survivors have longer, shorter, or similar survival compared to the background population. This knowledge could contribute to evidence-based monitoring strategies, healthcare recommendations, and information for patients and families.

Methods
This population-based cohort study included all patients who underwent gastrectomy for gastric adenocarcinoma between 2006–2015 in Sweden and survived ≥ 5 years after surgery. They were followed up until death, postoperative year 10, or end of study period (31 December, 2020). Division of the observed by the expected survival yielded relative survival rates with 95% confidence intervals (CIs) using the life table method. The expected survival was derived from the entire Swedish population of the corresponding age, sex, and calendar year. Data came from medical records and nationwide registers.

Results
The survival among all 767 gastric adenocarcinoma survivors was shorter than the expected. The reduction in relative survival increased for each follow-up year, from 97.3% (95% CI 95.4–99.1%) year 6 to 86.6% (95% CI 82.3–90.9%) year 10. The decline in relative survival was more pronounced among patients who had gastrectomy in earlier calendar years (82.9% [95% CI 77.4–88.4%] year 10 for years 2011–2015), shorter education (85.2% [95% CI 77.4–93.0%] year 10 for education ≤ 9 years), more comorbidities (78.0% [95% CI 63.9–92.0%] year 10 for Charlson comorbidity score ≥ 2), and no neoadjuvant therapy (83.2% [95% CI 77.4–89.0%] year 10).

Conclusion
Gastric adenocarcinoma survivors seem to have poorer survival than the corresponding background population, particularly in certain subgroups.
Stochastic assessment of special-rate life annuities
Authors: Olivieri Annamaria , Tabakova Daniela 
Published: September 2024

AbstractSpecial-rate life annuities offer customized annuity rates, based on the lifestyle or health status of the individual. Their main purpose is to encourage the annuity demand, which is still underdeveloped in many markets; as better annuity rates are quoted for individuals showing a higher mortality profile, the number of individuals attracted by life annuities could increase. Providers should then gain larger pool sizes; however, this is possibly matched by a greater heterogeneity of the pool, due to several risk classes defined by the annuity design. Heterogeneity emerges not only in terms of different life expectancies, but also in respect of the dispersion of the lifetime distribution; indeed, situations resulting in a lower life expectancy also show greater variability of the lifetime. As it is well-known, pooling effects are reinforced by the pool size, while they are weakened by its heterogeneity, with a possibly unclear impact on the overall longevity risk to which the provider is exposed. In this paper we investigate the longevity risk profile of an annuity pool consisting of several risk classes. We consider both the idiosyncratic and aggregate components of the risk, by modelling the random number of deaths and assuming a stochastic mortality dynamics. The heterogeneity of risk classes is represented alternatively in a deterministic and stochastic setting. Our conclusions are in line with similar findings discussed in the literature, but obtained in a deterministic framework. Results suggest that the longevity risk profile of the provider is not significantly undermined by a greater pool heterogeneity, with a prevalence of the aggregate component whatever the pool composition.
Diagnostic accuracy of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in rheumatoid arthritis: a systematic review and meta-analysis
Authors: Mangoni Arduino A. , Zinellu Angelo 
Published: September 2024

AbstractExisting challenges with the early diagnosis of rheumatoid arthritis (RA) and active disease, mainly by non-rheumatologists, have prompted the search for novel biomarkers. Elevations in indices derived from blood cell counts, e.g., the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), have been reported in RA patients. However, their diagnostic accuracy has not been comprehensively assessed. Therefore, we conducted a systematic review and meta-analysis of studies reporting the sensitivity and specificity of the NLR and PLR, obtained by receiver operating characteristic (ROC) curve analysis, for the presence of RA and active disease. We searched electronic databases from inception to 15 March 2024 and assessed the risk of bias using the JBI Critical Appraisal Checklist (PROSPERO registration number: CRD42024533546). In 15 studies, the NLR exhibited acceptable accuracy for the presence of RA (area under the curve, AUC = 0.76, 95% CI 0.72 to 0.80) and active disease (AUC = 0.70, 95% CI 0.66 to 0.74). The PLR exhibited good accuracy for the presence of RA (AUC = 0.80, 95% CI 0.76 to 0.83). There were insufficient studies to assess the accuracy of the PLR for the presence of active disease. Our systematic review and meta-analysis suggests that the NLR and the PLR are promising biomarkers of RA (NLR and PLR) and active disease (NLR). Further research is required to investigate whether the NLR and PLR can significantly enhance the capacity to diagnose RA and active disease in clinical practice.
Ultrasound Probe Pressure Affects Aortic Wall Stiffness: A Patient-Specific Computational Study in Abdominal Aortic Aneurysms
Authors: Bracco Marta Irene , Yousefi Ali Akbar Karkhaneh , Rouet Laurence , Avril Stéphane 
Published: September 2024

Abstract

Purpose:
Ultrasound imaging is key in the management of patients with an abdominal aortic aneurysm (AAA). It was recently shown that the cyclic diameter variations between diastole and systole, which can be quantified with US imaging, increase significantly with the strength of the applied probe pressure on the patient’s abdomen. The goal of this study is to investigate this effect more thoroughly.

Methods:
With finite-element modeling, pulsatile blood pressure and probe pressure are simulated in three patient-specific geometries. Two distinct models for the aortic wall were simulated: a nonlinear hyperelastic and a linear elastic model. In addition, varying stiffness was considered for the surrounding tissues. The effect of light, moderate, and firm probe pressure was quantified on the stresses and strains in the aortic wall, and on two in vivo stiffness measures. In addition, the Elasticity Loss Index was proposed to quantify the change in stiffness due to probe pressure.

Results:
Firm probe pressure decreased the measured aortic stiffness, and material stiffness was affected only when the wall was modeled as nonlinear, suggesting a shift in the stress–strain curve. In addition, stiffer surrounding tissues and a more elongated aneurysm sac decreased the responsiveness to the probe pressure.

Conclusion:
The effect of probe pressure on the AAA wall stiffness was clarified. In particular, the AAA wall nonlinear behavior was found to be of primary importance in determining the probe pressure response. Thus, further work will intend to make use of this novel finding in a clinical context.
Anthropogenic and climatic impacts on historic sediment, carbon, and phosphorus accumulation rates using 210Pbex and 137Cs in a sub-watershed linked to Zarivar Lake, Iran
Authors: Khodadadi Maral , Gibbs Max , Swales Andrew , Toloza Arsenio , Blake William H. 
Published: September 2024

AbstractTo estimate a watershed’s response to climate change, it is crucial to understand how human activities and climatic extremes have interacted over time. Over the last century, the Zarivar Lake watershed, Iran, has been subjected to various anthropogenic activates, including deforestation and inappropriate land-management practices alongside the implementation of conservation measures like check dams. To understand the effects of these changes on the magnitude of sediment, organic carbon (OC), and phosphorus supplies in a small sub-watershed connected to the lake over the last century, a lake sediment core was dated using 210Pbex and 137Cs as geochronometers. The average mass accumulation rate (MAR), organic carbon accumulation rates (OCAR), and particulate phosphorus accumulation rates (PPAR) of the sediment core were determined to be 6498 ± 2475, 205 ± 85, and 8.9 ± 3.3 g m−2 year−1, respectively. Between the late 1970s and early 1980s, accumulation rates were significantly higher than their averages at 7940 ± 3120, 220 ± 60, and 12.0 ± 2.8 g m−2 year−1 respectively. During this period, the watershed underwent extensive deforestation (12%) on steep slopes, coinciding with higher mean annual precipitations (more than double). Conversely, after 2009, when check dams were installed in the sub-watershed, the sediment load to the lake became negligible. The results of this research indicate that anthropogenic activities had a pronounced effect on MAR, OCAR, and PPAR, causing them to fluctuate from negligible amounts to values twice the averages over the last century, amplified by climatic factors. These results imply that implementing climate-smart watershed management strategies, such as constructing additional check dams and terraces, reinforcing restrictions on deforestation, and minimum tillage practices, can facilitate protection of lacustrine ecosystems under accelerating climate change conditions.
Graphical Abstract
Assessing Scientific Inquiry: A Systematic Literature Review of Tasks, Tools and Techniques
Authors: Vo De Van , Simmie Geraldine Mooney 
Published: September 2024

AbstractWhile national curricula in science education highlight the importance of inquiry-based learning, assessing students’ capabilities in scientific inquiry remains a subject of debate. Our study explored the construction, developmental trends and validation techniques in relation to assessing scientific inquiry using a systematic literature review from 2000 to 2024. We used PRISMA guidelines in combination with bibliometric and Epistemic Network Analyses. Sixty-three studies were selected, across all education sectors and with a majority of studies in secondary education. Results showed that assessing scientific inquiry has been considered around the world, with a growing number (37.0%) involving global researcher networks focusing on novel modelling approaches and simulation performance in digital-based environments. Although there was modest variation between the frameworks, studies were mainly concerned with cognitive processes and psychological characteristics and were reified from wider ethical, affective, intersectional and socio-cultural considerations. Four core categories (formulating questions/hypotheses, designing experiments, analysing data, and drawing conclusions) were most often used with nine specific components (formulate questions formulate prediction/hypotheses, set experiment, vary independent variable, measure dependent variable, control confounding variables, describe data, interpret data, reach reasonable conclusion). There was evidence of transitioning from traditional to online modes, facilitated by interactive simulations, but the independent tests and performance assessments, in both multiple-choice and open-ended formats remained the most frequently used approach with a greater emphasis on context than heretofore. The findings will be especially useful for science teachers, researchers and policy decision makers with an active interest in assessing capabilities in scientific inquiry.
Towards compressed and efficient CNN architectures via pruning
Authors: Narkhede Meenal , Mahajan Shrinivas , Bartakke Prashant , Sutaone Mukul 
Published: September 2024

AbstractConvolutional Neural Networks (CNNs) use convolutional kernels to extract important low-level to high-level features from data. The performance of CNNs improves as they grow deep thereby learning better representations of the data. However, such deep CNNs are compute and memory-intensive, making deployment on resource-constrained devices challenging. To address this, the CNNs are compressed by adopting pruning strategies that remove redundant convolutional kernels from each layer while maintaining accuracy. Existing pruning methods that are based on feature map importance, only prune the convolutional layers uniformly and do not consider fully connected layers. Also, current techniques do not take into account class labels while pruning the less important feature maps and do not explore the need for retraining after pruning. This paper presents pruning techniques to prune convolutional and fully connected layers. This paper proposes a novel class-specific pruning strategy based on finding feature map importance in terms of entropy for convolutional layers and the number of incoming zeros to neurons for fully connected layers. The class-specific approach helps to have a different pruning threshold for every convolutional layer and ensures that the pruning threshold is not influenced by any particular class. A study on the need for retraining the entire network or a part of the network after pruning is also carried out. For Intel image, CIFAR10 and CIFAR100 datasets the proposed pruning method has compressed AlexNet by 83.2%, 87.19%, and 79.7%, VGG-16 by 83.7%, 85.11%, and 84.06% and ResNet-50 by 62.99%, 62.3% and 58.34% respectively.
Gap in Sexual Dysfunction Management Between Male and Female Patients Seen in Primary Care: An Observational Study
Authors: Stanley Elizabeth E. , Pfoh Elizabeth , Lipold Laura , Martinez Kathryn 
Published: September 2024

Abstract
Background
Female sexual dysfunction (FSD), defined as clinically distressing problems with desire, arousal, orgasm, or pain, affects 12% of US women. Despite availability of medications for FSD, primary care physicians (PCPs) report feeling underprepared to manage it. In contrast, erectile dysfunction (ED) is frequently treated in primary care.

Objective
To describe differences in patterns of FSD and ED diagnosis and management in primary care patients.

Design
Retrospective observational study.

Subjects
Primary care patients with an incident diagnosis of FSD or ED seen at a large, integrated health system between 2016 and 2022.

Main Measures
Sexual dysfunction management (referral or prescription of a guideline-concordant medication within 3 days of diagnosis), patient characteristics (age, race, insurance type, marital status), and specialty of physician who diagnosed sexual dysfunction. We estimated the odds of FSD and ED management using mixed effects logistic regression in separate models.

Key Results
The sample included 6540 female patients newly diagnosed with FSD and 16,591 male patients newly diagnosed with ED. Twenty-two percent of FSD diagnoses were made by PCPs, and 38% by OB/GYNs. Forty percent of ED diagnoses were made by PCPs and 20% by urologists. Patients with FSD were managed less frequently (33%) than ED patients (41%). The majority of FSD and ED patients who were managed received a medication (96% and 97%, respectively). In the multivariable models, compared to diagnosis by a specialist, diagnosis by a PCP was associated with lower odds of management for FSD patients (aOR, 0.59; 95% CI, 0.51–0.69) and higher odds of management (aOR, 1.52; 95% CI, 1.36–1.64) for ED patients.

Conclusions
Primary care patients with FSD are less likely to receive management if they are diagnosed by a PCP than by an OB/GYN. The opposite was true of ED patients, exposing a gap in the quality of care female patients receive.

Graphical abstract
Management of patients with adrenal myelolipoma: experience from a tertiary referral centre
Authors: Paul Anant , Toale Conor , Egan Marie , Whelan Maria , Feeney John , Crowther Stephen , Gibney James , Conlon Kevin 
Published: September 2024

Abstract
Background
Adrenal myelolipomas are rare, benign, tumours of the adrenal cortex.

Aims
This study reports the experience of a tertiary adrenal surgery referral centre’s approach to the management of patients with adrenal myelolipoma.

Methods
A retrospective observational cohort study was conducted on all adult patients (> 18 years age) diagnosed with adrenal myelolipoma from January 1, 2014, to December 30, 2022. Demographics, imaging characteristics, histological diagnosis (where applicable) and follow-up data were compared between patients undergoing surgery and those referred to surveillance. Indications for operative intervention were recorded at the time of multidisciplinary team discussion, consisting of surgeons, endocrinology physicians, radiologists, pathologists and specialist nursing representatives.

Results
Of the 522 patients with an adrenal lesion discussed in adrenal tumour meeting between 2014 and 2022, n = 15 (2.8%) were diagnosed with adrenal myelolipoma. Of the 15 patients, 4 underwent adrenalectomy at first presentation (27%), while 1 patient underwent adrenalectomy after interval follow-up. Indications for operative intervention were as follows: ‘indeterminate lesion’ (n = 3), ‘abdominal pain and size (> 4 cm)’ (n = 1) and ‘mass effect on adjacent organs’ (n = 1). The mean rate of lesion growth in patients referred for surveillance (n = 10) was 0.13 cm/year. Histology confirmed adrenal myelolipoma as the diagnosis in all resected tumours.

Conclusions
For patients with adrenal myelolipoma, the presence of symptoms and/or indeterminate features on imaging may be more clinically useful indications for operative intervention over size alone. The surveillance of adrenal myelolipomas, even in patients with adrenal lesions > 4 cm, is a safe clinical strategy, provided the imaging characteristics are benign and patients remain asymptomatic.
HERO in action (crisis): the role of psychological capital in experiencing an action crisis
Authors: Kačmár Pavol , Versolker Noa Rachel , Falah Hadyeh 
Published: September 2024

AbstractIn some situations, goal striving does not go without problems, leading to intrapsychic decisional conflict between giving up and persisting in problematic goal striving, known as an action crisis. However, only limited attention has been devoted to cultivable positive psychological resources that can shield individuals from an action crisis development. In the six studies, we examined the role of psychological capital (PsyCap), the higher-order construct based on similarities between hope, self-efficacy, resilience, and optimism and their unique characteristics in an action crisis experience. A pilot study (N = 295) established a link between variables, indicating that the more PsyCap participants had, the fewer action crises they experienced (and vice versa). In a preregistered follow-up study (N = 210), this finding was replicated. Furthermore, it was shown that the relationship was indirect, potentially mediated by the appraisals of goal attainment. In the third study (N = 411), some essential aspects were varied. The main findings were conceptually replicated, showing that PsyCap was associated with action crisis and predicted it above and beyond selected personality traits (negative emotionality and conscientiousness). In the fourth and fifth study (N = 272 and N = 268), the indirect role of goal-related negative emotions, controlled motivation, and effort was supported. Also, results were partially extended to goal progress. However, in a longitudinal study (N = 254) with the random intercept cross-lagged panel model, it was shown that although the average level of PsyCap across time points is negatively associated with the average level of action crisis (i.e., the between-person effect was supported), the cross-lagged within-subject effect of PsyCap on action crisis was not supported.
Splice-altering variant of PJVK gene in a Mauritanian family with non-syndromic hearing impairment
Authors: Salame Malak , Bonnet Crystel , Singh-Estivalet Amrit , Brahim Selma Mohamed , Roux Solene , Boussaty Ely Cheikh , Hadrami Mouna , Hamed Cheikh Tijani , Sidi Abdellahi M’hamed , Veten Fatimetou , Petit Christine , Houmeida Ahmed 
Published: September 2024

AbstractPJVK gene was recently shown to create hypervulnerability to sound in humans and was the first human gene implicated in non-syndromic hearing impairment due to neural defect. Targeted next-generation sequencing of over 150 known deafness genes was performed in the proband. Sanger sequencing was used to validate the PJVK variant and confirm familial segregation of the disease. A minigene-based assay has been performed to assess the impact of the variant on splicing. We identified a novel c.550-6A > G acceptor splice-site variant in the PJVK gene in the homozygous state in a Mauritanian child with severe to profound congenital deafness. The substitution was located in intron 4. The effect of the variation was demonstrated by a minigene assay which showed that the variation, an insertion of an additional 5 bp, created a new splice site resulting in the appearance of a premature stop codon (p.Phe184Tyrfs*26) and likely a truncated protein. This result constitutes a new splice-site variant report in the PJVK gene leading to DFNB59 type associated with autosomal recessive non-syndromic hearing impairment (ARNSHI).
Spatial Variability and Source Identification of Trace Elements in Aerosols From Northwest Pacific Marginal Sea, Indian Ocean and South Pacific to Antarctica
Authors: Ge Yuncong , Guan Wenkai , Wong Kuo Hong , Zhang Ruifeng 
Published: September 2024

AbstractAerosols continuously transport trace elements (TEs) across long distances to the ocean, fueling marine primary production and affecting global carbon cycles. Given the multiple sources and complex transport mechanisms, field investigations of aerosol TEs on a global scale are significant for understanding their role in marine biogeochemical cycles. Here, aerosol samples were collected along a 50,000‐km route covering subtropical Northwest Pacific (NWP) marginal seas, Indian Ocean, Southern Ocean, Drake Passage, and South Pacific. Samples were analyzed for the concentrations of Al, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Tl, and Pb. Aerosol TEs were distributed heterogeneously, with significantly lower concentrations over remote oceans compared to coastal seas. Meanwhile, TE concentrations were generally high in the Indian Ocean, moderate in the Southern Ocean, and low in the South Pacific. Cr, Ni, Cu, Zn, Cd, As, and Pb were widely enriched, primarily originating from anthropogenic sources, while Al, Ti, V, Mn, Fe, and Co were mainly from crustal sources in remote oceans. Moreover, specific sources of TEs were clarified, for example, Cr and Ni were mainly from vehicle emissions. The estimated bulk TE deposition fluxes also varied spatially. For instance, the greatest deposition of Fe occurs in the NWP marginal sea, followed by the Drake Passage, Indian Ocean Sector of Southern Ocean, Pacific Sector of Southern Ocean, and South Pacific. This study contributes to a deeper understanding of the complex dynamics of aerosol TEs in the global ocean, providing valuable information for future studies and policy making regarding climate change.