bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracted: Analgesic effects of microRNA‐129‐5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice
Authors: Yu Shao‐Nan , Liu Gui‐Feng , Li Long‐Yun , Zhao Guo‐Qing , Liu Lin , Li Xue‐Feng 
Published: December 2017

AbstractThe study aims to investigate the analgesic effects of microRNA‐129‐5p (miR‐129‐5p) on bone cancer pain (BCP) by targeting Eph receptor B1 (EphB1) through the EphB1/EphrinB2 signaling pathway. BCP mice models were established, and C3H/HeJ female mice were classified into the normal, blank, negative control (NC), miR‐129‐5p mimics, miR‐129‐5p inhibitors, EphB1 knockout (KO), and miR‐129‐5p inhibitors + EphB1 KO groups. Quantitative reverse transcription polymerase chain reaction and Western blot analysis were used to evaluate the miR‐129‐5p expression, and messenger RNA (mRNA) and protein expressions of EphB1, p‐EphB1, EphrinB2, and p‐EphrinB2. EphB1 and EphrinB2 were highly activated in the tibias of BCP mice 7 days after the operation. EphB1 is a target gene of miR‐129‐5p. The mechanical withdrawal threshold increased in the miR‐129‐5p mimics, EphB1 KO and miR‐129‐5p inhibitors + EphB1 KO groups, but decreased in the miR‐129‐5p inhibitors group. Compared with the blank and the NC groups, the expression of miR‐129‐5p was significantly increased in the miR‐129‐5p mimics group, and the mRNA and protein expressions of EphrinB2, p‐EphrinB2, EphB1, and p‐EphB1 were significantly decreased, while in the miR‐129‐5p inhibitors group, the results were opposite (all
P < 0.05); the mRNA and protein expressions of EphrinB2, p‐EphrinB2, EphB1, and p‐EphB1 were significantly decreased in the EphB1 KO group (all
P < 0.05); the expression of miR‐129‐5p was significantly decreased in the miR‐129‐5p inhibitors + EphB1 KO group (
P < 0.05), while the mRNA and protein expressions of EphrinB2 and p‐EphrinB2 were not significantly different (
P > 0.05). The results indicated that upregulated miR‐129‐5p alleviate BCP via downregulation of the EphB1/EphrinB2 signaling pathway.
Interleukin‐4 induces a CD44high/CD49bhigh PC3 subpopulation with tumor‐initiating characteristics
Authors: Erb Holger H.H. , Guggenberger Fabian , Santer Frédéric R. , Culig Zoran 
Published: December 2017

AbstractPro‐ and anti‐inflammatory cytokines may influence proliferation, migration, invasion, and other cellular events of prostate cancer (PCa) cells. The hyaluronan receptor CD44, which is regulated by Interleukin (IL)‐4, is a prostate basal cell marker. CD44high/CD49bhigh expressing cells have been demonstrated to have tumor‐initiating characteristics. Here, we aimed to analyze the effects of long‐term IL‐4 treatment on CD44/CD49b expression, migration, proliferation, and clonogenic potential of basal‐like PCa cells. To this end PC3 cells were treated over 30 passages with 5 ng/mL IL‐4 (PC3‐IL4) resulting in an increased population of CD44high expressing cells. This was concurrent with a clonal outgrowth of cuboid‐shaped cells, with increased size and light absorbance properties. Flow cytometry revealed that the PC3‐IL4 CD44high expressing subpopulation corresponds to the CD49bhigh population. Isolation of the PC3‐IL4 CD44high/CD49bhigh subpopulation via fluorescence‐associated cell sorting showed increased migrative, proliferative, and clonogenic potential compared to the CD44low/CD49blow subpopulation. In conclusion, IL‐4 increases a PC3 subpopulation with tumor‐initiating characteristics. Thus, IL‐4, similar to other cytokines may be a regulator of tumor‐initiation and hence, may present a suitable therapy target in combination with current treatment options.
Longitudinal assessment of rabbit renal fibrosis induced by unilateral ureteral obstruction using two‐dimensional susceptibility weighted imaging
Authors: Zhang Jing‐Gang , Xing Zhao‐Yu , Zha Ting‐Ting , Tian Xiao‐Juan , Du Ya‐Nan , Chen Jie , Xing Wei 
Published: December 2017

BACKGROUNDPrevious studies indicated that two‐dimensional‐susceptibility weighted imaging (2D‐SWI) could serve as a useful biomarker for differentiating the grade of liver fibrosis.PURPOSETo evaluate the feasibility of 2D‐SWI in the dynamic quantification of renal fibrosis in a rabbit model.STUDY TYPE: Longitudinal study.ANIMAL MODELTwenty‐Four New Zealand White Rabbits including control group (n = 4); and renal fibrosis group (n = 20), by means of a unilateral ureteral obstruction (UUO) model.FIELD STRENGTH/SEQUENCEThe 3.0 T SWI using a 2D gradient‐echo sequence.ASSESSMENTThe relative SWI signal ratio(r) of cortical and medulla (r = SIrenal/SImuscle) was longitudinally assessed before ligation and on weeks 2, 4, 6, and 8 following ligation. Sirius Red staining was used to assess the degree of fibrosis in five high‐power fields.STATISTICAL TESTSThe repeated measures of analysis of variance and linear regression analysis.RESULTSBoth the cortical and medullary r values were significantly higher in the UUO kidneys at week 2 compared with the kidneys before ligation. Over the course of UUO progression, significant changes occurred in the cortical and medullary r values in vivo and fibrosis scores in vitro (all P values < 0.05). The r values gradually decreased, while the fibrosis scores gradually increased over 8 weeks following ligation. The linear regression analysis showed a strong and significant correlation between cortical and medullary r values and the pathologic fibrosis scores (R2 = 0.91, 0.81, respectively).DATA CONCLUSIONThe SWI sequence could provide a quantitative evaluation of renal fibrosis during UUO progression.Level of Evidence: 2Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2018;47:1572–1577.
Homonuclear decoupling in the 13C indirect dimension of HSQC experiments for 13C‐enriched compounds
Authors: Brucka Marta , Sheberstov Kirill F. , Jeannerat Damien 
Published: December 2017

The two most compelling methods for broadband homonuclear decoupling currently available, Zangger–Sterk (ZS) and pure shift yielded by chirp excitation (PSYCHE), were successfully adapted and tested on the 13C isotope. When applied during the indirect carbon evolution in the HSQC experiment, they both entirely eliminated the extended carbon–carbon multiplet structures observed in this dimension of a non‐decoupled HSQC spectrum of 13C‐enriched cholesterol. The optimized selective pulse modulated using novel non‐equidistant scheme for multisite refocusing (ZS) and the small flip angle saltire chirps (PSYCHE) both proved to be robust and efficient in providing decoupled spectra with a sensitivity of about 25% that of the non‐decoupled HSQC spectra with improved quality compared to earlier results.
An approximate method for solving fractional optimal control problems by the hybrid of block‐pulse functions and Taylor polynomials
Authors: Yonthanthum W. , Rattana A. , Razzaghi M. 
Published: December 2017

SummaryIn this paper, an efficient and accurate computational method based on the hybrid of block‐pulse functions and Taylor polynomials is proposed for solving a class of fractional optimal control problems. In the proposed method, the Riemann‐Liouville fractional integral operator for the hybrid of block‐pulse functions and Taylor polynomials is given. By taking into account the property of this operator, the solution of fractional optimal control problems under consideration is reduced to a nonlinear programming one to which existing well‐developed algorithms may be applied. The present method applies to both fractional optimal control problems with or without inequality constraints. The method is computationally very attractive and gives very accurate results. Easy implementation and simple operations are the essential features of the proposed hybrid functions. Illustrative examples are given to assess the effectiveness of the developed approximation technique.
Adduction of ammonium to polylactides to modify their dissociation behavior in collision‐induced dissociation
Authors: Chendo Christophe , Phan Trang N.T. , Rollet Marion , Gigmes Didier , Charles Laurence 
Published: December 2017

RationaleThe goal of this work was to modify the dissociation pathways of polylactide (PLA) holding benzyl and hydroxyl terminations, in order to circumvent coincidence of product ions generated during collisional activation of sodiated chains, which prevented their reliable characterization.MethodsBenzyl‐, hydroxyl‐terminated PLAs were ionized as ammonium adducts in positive ion mode electrospray and subjected to collision‐induced dissociation (CID). Tandem mass spectrometry (MS/MS) experiments were conducted in a quadrupole time‐of‐flight (QTOF) instrument for safe assignment of product ions based on their elemental composition derived from accurate mass measurements.ResultsAdduction of ammonium to PLAs was found to induce chain fragmentation via charge‐assisted processes, in great contrast to the charge‐remote mechanisms experienced by sodiated molecules. The main reaction produced ions containing the ω termination only, hence allowing straightforward end‐group determination. Other minor pathways were studied in detail to establish dissociation rules for ammoniated PLAs. Some reactions were found to be end‐group specific, highlighting the higher reactivity of ammonium than alkali ion adducts.ConclusionsChanging the usually employed sodium‐cationizing agent to ammonium was shown to induce dramatic changes in the CID behavior of PLAs. This was a simple and efficient approach to address issues encountered for end‐group analysis of the particular PLA studied here.
Self‐imposed pressure or organizational norms? Further examination of the construct of workplace telepressure
Authors: Grawitch Matthew J. , Werth Paul M. , Palmer Sarah N. , Erb Kaitlyn R. , Lavigne Kristi N. 
Published: December 2017

AbstractInformation and communication technologies (ICTs) are rapidly becoming indispensable organizational tools. Though the benefits of such technologies have been trumpeted, recent research has examined the unique pressures that may be introduced through the lens of a construct called workplace telepressure, defined as an urge for and preoccupation with quickly responding to ICTs (e.g., email). The current study further explores the workplace telepressure construct as a unique contributor to measures of workplace well‐being over and above perceived workplace demands and individual differences, introducing new constructs into the study of workplace telepressure. Furthermore, the study critically evaluates the term “telepressure” as applied to the underlying construct, as “pressure” may connote a perception of external force being placed on an individual, whereas the definition offered by past research identifies a preoccupation and urge to respond immediately to ICT messages, which may be internally generated. Finally, the ability of workplace telepressure to account for unique variance in workplace subjective well‐being measures is investigated.
Risk Factors for Central Neck Lymph Node Metastases in Micro‐ Versus Macro‐ Clinically Node Negative Papillary Thyroid Carcinoma
Authors: Sessa Luca , Lombardi Celestino Pio , De Crea Carmela , Tempera Serena Elisa , Bellantone Rocco , Raffaelli Marco 
Published: December 2017

AbstractBackgroundTumor size has been advocated as possible risk factors for occult central lymph node metastases (CNM) in papillary thyroid carcinoma (PTC) patients. This prospective study evaluated factors that could identify patients at higher risk of occult CNM, especially comparing micro‐PTC and macro‐PTC.MethodsOne hundred and eighty‐six patients were recruited. All the patients had cN0 clinically unifocal PTC and underwent total thyroidectomy and bilateral prophylactic central neck dissection. Risk factors for occult CNM in micro‐ and macro‐PTC patients were evaluated.ResultsEighty‐two patients showed CNM. The rate of CNM did not differ among different sizes cut off (≤20 mm, ≤10 mm, ≤5 mm P = NS). Significantly more pN1a than pN0 patients had pT3 tumors (35/82 vs. 26/104) (P < 0.05), extracapsular invasion (35/82 vs. 22/104) (P < 0.01) and microscopic multifocal disease (50/82 vs. 47/104) (P < 0.05). Independent risk factors for CNM were extracapsular invasion and multifocality at multivariate analysis. Risk factors for CNM in 77 micro‐PTC were extracapsular invasion (16/31 pN1 vs. 10/46 pN0, P < 0.05) and multifocality (21/31 pN1 vs. 16/46 pN0, P < 0.01). Among 109 macro‐PTC, risk factors for CNM were angioinvasion (15/51 pN1 vs. 7/58 pN0, P < 0.05) and classic PTC at the final histology (PTC vs. tall cell variant vs. follicular variant PTC) (P < 0.05).ConclusionsRisk factors for CNM can differ between micro‐ and macro‐PTC, but no preoperatively known clinical parameter is predictor of CNM in cN0 clinically unifocal PTC.
Video‐Assisted Thyroidectomy for Papillary Thyroid Carcinoma: Oncologic Outcome in Patients with Follow‐Up ≥ 10 Years
Authors: Bellantone Rocco , Raffaelli Marco , De Crea Carmela , Sessa Luca , Traini Emanuela , Princi Pietro , Lombardi Celestino Pio 
Published: December 2017

AbstractBackgroundVideo‐assisted thyroidectomy (VAT) arisen as a valid treatment for selected patients with papillary thyroid carcinoma (PTC), but no data concerning long‐term oncologic outcome are available. The primary aim of the study was to evaluate the oncologic outcome of patients who underwent VAT for PTC with a follow‐up ≥ 10 years.MethodsThe medical charts of all the patients who successfully underwent VAT for PTC were reviewed. The patients with a minimum follow‐up period of 120‐months were included. Patients with unifocal PTC ≤ 1 cm, in the absence of lymph node metastases, without gross extracapsular invasion and age < 45 years were considered “low‐risk” patients and followed with ultrasound and serum thyroglobulin (sTg) on levothyroxine (LT4); the remaining patients underwent nuclear medicine evaluation.ResultsTwo hundred and fifty‐seven patients, operated on between May 2000 and October 2006, were included. Postoperative complications included four transient recurrent palsies, 76 transient and 1 permanent hypocalcemia. One hundred and four low‐risk patients were followed with ultrasound and sTg on LT4. At a mean follow‐up of 136.6 months, mean sTg on LT4 was 0.1 ± 0.1 ng/ml. None of them showed recurrence. The remaining 153 patients underwent nuclear medicine evaluation. Among these 153, 62 did not undergo radioiodine ablation (RAI). At a mean follow‐up of 150.8 months, mean sTg on LT4 was 0.1 ± 0.1 ng/ml. None of them showed recurrence. The remaining 91 patients underwent RAI. Mean pre‐RAI sTg off‐LT4 was 8.3 ± 5.8 ng/ml, mean radioiodine uptake was 2.8 ± 4.4%. Among these 91, three pN1a patients developed a lateral neck node recurrence. No other recurrence was registered. At the latest follow‐up mean sTg on LT4 in this subgroup of patients was 0.1 ± 0.2 ng/ml.ConclusionsThe long‐term (≥ 10 years) oncologic outcome further demonstrates that VAT is a valid option for selected PTC patients.
Interactome Analysis of Microtubule-Targeting Agents Reveals Cytotoxicity Bases in Normal Cells
Authors: Gutiérrez-Escobar Andrés Julián , Méndez-Callejas Gina 
Published: December 2017

Abstract
Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity of MTA targets, we analyzed the interaction network in a non-cancerous human cell. Subnetworks of fourteen MTAs were reconstructed and the merged network was compared against a randomized network to evaluate the functional richness. We found that 71.4% of the MTA interactome nodes are shared, which affects cellular processes such as apoptosis, cell differentiation, cell cycle control, stress response, and regulation of energy metabolism. Additionally, possible secondary targets were identified as client proteins of interphase microtubules. MTAs affect apoptosis signaling pathways by interacting with client proteins of interphase microtubules, suggesting that their primary targets are non-tumor cells. The paclitaxel and doxorubicin networks share essential topological axes, suggesting synergistic effects. This may explain the exacerbated toxicity observed when paclitaxel and doxorubicin are used in combination for cancer treatment.
The Ability of Different Imputation Methods to Preserve the Significant Genes and Pathways in Cancer
Authors: Aghdam Rosa , Baghfalaki Taban , Khosravi Pegah , Saberi Ansari Elnaz 
Published: December 2017

Abstract
Deciphering important genes and pathways from incomplete gene expression data could facilitate a better understanding of cancer. Different imputation methods can be applied to estimate the missing values. In our study, we evaluated various imputation methods for their performance in preserving significant genes and pathways. In the first step, 5% genes are considered in random for two types of ignorable and non-ignorable missingness mechanisms with various missing rates. Next, 10 well-known imputation methods were applied to the complete datasets. The significance analysis of microarrays (SAM) method was applied to detect the significant genes in rectal and lung cancers to showcase the utility of imputation approaches in preserving significant genes. To determine the impact of different imputation methods on the identification of important genes, the chi-squared test was used to compare the proportions of overlaps between significant genes detected from original data and those detected from the imputed datasets. Additionally, the significant genes are tested for their enrichment in important pathways, using the ConsensusPathDB. Our results showed that almost all the significant genes and pathways of the original dataset can be detected in all imputed datasets, indicating that there is no significant difference in the performance of various imputation methods tested. The source code and selected datasets are available on http://profiles.bs.ipm.ir/softwares/imputation_methods/.
DETERMINANTS OF WEANLING THOROUGHBRED AUCTION PRICES
Authors: HANSEN CHARLOTTE R. , STOWE C. JILL 
Published: December 2017

AbstractDeterminants of prices of 1,302 weanling Thoroughbreds sold at the 2010 Keeneland November Breeding Stock Sale are investigated. A hedonic pricing model is adopted to identify price determinants, and the corresponding marginal values of those determinants are estimated. Prices were responsive to pedigree quality variables, including the sire's stud fee, the stage of the sire's breeding career, and whether the dam or the dam's progeny had earned “black type.” In addition, individual weanling characteristics such as gender, age, state of birth, and sale placement influenced price. Results can be used as a decision tool by both buyers and sellers.
Alluvial fan depositional records from north and south-facing catchments in semi-arid montane terrain
Authors: Poulos Michael J. , Pierce Jennifer L. 
Published: December 2017

AbstractValley asymmetry reflects differences in landform evolution with aspect; however, few studies assess rates and timing of asymmetric erosion. In south-central Idaho, we combine alluvial fan volume reconstructions with radiocarbon deposit dating to compare the source-catchment normalized fan deposition rates of catchments incised into north (n=5) and south-facing (n=3) valleys, which differ during the late Holocene from 7.7 to 10.1 mm/ka, respectively, but are not significantly different. South-facing catchments produced 1.3× more fan sediment per unit source-area during the late Holocene, whereas over the last 10 Ma they have evolved to be 2.1× larger with 2.8× greater eroded volumes and 7.6° gentler slopes (24.5° versus 32.1°, average). Late Holocene differences in sediment yields with aspect cannot fully explain differences in landforms. Potential bias in sediment deposition and/or remobilization cannot fully explain the similarity of erosion rates during the late Holocene. Valley asymmetry appears to have developed primarily during different conditions. While valley asymmetry development may be quicker during glacial climates, development is likely accelerated early in a valley’s history, such as during initial valley incision, because asymmetric degradation serves as a negative feedback that reduces aspect-related differences in erosion and drives valleys towards steady state.
Elements of a comprehensive theory of infant imitation
Authors: Meltzoff Andrew N. 
Published: December 2017

AbstractImitation is central to human development. Imitation involves mapping between the perception and production of actions. Imitation after delays implicates preverbal memory. Imitation of people informs us about infants' processing of social events. A comprehensive theory needs to account for the origins, mechanisms, and functions of imitation. Neonatal imitation illuminates how the initial state engenders and supports rapid social learning.
Social exclusion of people with severe mental illness in Switzerland: results from the Swiss Health Survey
Authors: Richter D. , Hoffmann H. 
Published: December 2017

Aims.People with severe mental illness (SMI) have a high risk of living socially excluded from the mainstream society. Policy initiatives and health systems aim to improve the social situation of people who suffer from mental health disabilities. The aim of this study was to explore the extent of social exclusion (employment and income, social network and social activities, health problems) of people with SMI in Switzerland.Methods.Data from the Swiss Health Survey 2012 were used to compare the social exclusion magnitude of people with SMI with those suffering from severe physical illness, common mental illness and the general population.Results.With the exception of Instrumental Activities of Daily Living, we found a gradient of social exclusion that showed people with SMI to be more excluded than the comparison groups. Loneliness and poverty were widespread among people with SMI. Logistic regression analyses on each individual exclusion indicator revealed that people with SMI and people with severe physical illness were similarly excluded on many indicators, whereas people with common mental illness and the general population were much more socially included.Conclusions.In contrast to political and health system goals, many people with SMI suffer from social exclusion. Social policy and clinical support should increase the efforts to counter exclusionary trends, especially in terms of loneliness and poverty.
Resolution of habitat-associated ecogenomic signatures in bacteriophage genomes and application to microbial source tracking
Authors: Ogilvie Lesley A , Nzakizwanayo Jonathan , Guppy Fergus M , Dedi Cinzia , Diston David , Taylor Huw , Ebdon James , Jones Brian V 
Published: December 2017

Abstract
Just as the expansion in genome sequencing has revealed and permitted the exploitation of phylogenetic signals embedded in bacterial genomes, the application of metagenomics has begun to provide similar insights at the ecosystem level for microbial communities. However, little is known regarding this aspect of bacteriophage associated with microbial ecosystems, and if phage encode discernible habitat-associated signals diagnostic of underlying microbiomes. Here we demonstrate that individual phage can encode clear habitat-related ‘ecogenomic signatures’, based on relative representation of phage-encoded gene homologues in metagenomic data sets. Furthermore, we show the ecogenomic signature encoded by the gut-associated ɸB124-14 can be used to segregate metagenomes according to environmental origin, and distinguish ‘contaminated’ environmental metagenomes (subject to simulated in silico human faecal pollution) from uncontaminated data sets. This indicates phage-encoded ecological signals likely possess sufficient discriminatory power for use in biotechnological applications, such as development of microbial source tracking tools for monitoring water quality.