bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of comorbidity on mortality in multiple myeloma: a Danish nationwide population‐based study
Authors: Gregersen Henrik , Vangsted Annette Juul , Abildgaard Niels , Andersen Niels Frost , Pedersen Robert Schou , Frølund Ulf Christian , Helleberg Carsten , Broch Bettina , Pedersen Per Trøllund , Gimsing Peter , Klausen Tobias Wirenfeldt 
Published: June 2017

AbstractTo describe the prevalence of comorbidity and its impact on survival in newly diagnosed multiple myeloma patients compared with population controls. Cases of newly diagnosed symptomatic multiple myeloma during the 2005–2012 period were identified in the Danish National Multiple Myeloma Registry. For each myeloma patient, 10 members of the general population matched by age and sex were chosen from the national Civil Registration System. Data on comorbidity in the myeloma patients and the general population comparison cohort were collected by linkage to the Danish National Patient Registry (DNPR). Cox proportional hazards regression models were used to evaluate the prognostic significance of comorbidity. The study included 2190 cases of multiple myeloma and 21,900 population controls. The comorbidity was increased in multiple myeloma patients compared with population controls, odds ratio (OR) 1.4 (1.1–1.7). The registration of comorbidity was highly increased within the year preceding diagnosis of multiple myeloma (OR 3.0 [2.5–3.5]), which was attributable to an increased registration of various diseases, in particular, renal disease with OR 11.0 (8.1–14.9). The median follow‐up time from diagnosis of multiple myeloma for patients alive was 4.3 years (interquartile range 2.4–6.3). Patients with registered comorbidity had increased mortality compared with patients without comorbidity, hazard ratio 1.6 (1.5–1.8). Multiple myeloma patients have increased comorbidity compared with the background population, in particular during the year preceding the diagnosis of myeloma.
Acute changes in histopathology and intravascular imaging after catheter‐based renal denervation in a porcine model
Authors: Sakaoka Atsushi , Takami Akiyuki , Onimura Yuji , Hagiwara Hitomi , Terao Hisako , Kumagai Fumiaki , Matsumura Kiyoshi 
Published: June 2017

AbstractObjectivesWe first aimed to identify the histopathological changes occurring immediately after renal denervation (RDN) with radiofrequency energy, and then to assess the feasibility of determining procedural success using currently available clinical intravascular imaging techniques.BackgroundCatheter‐based RDN has been used as an alternative therapy for hypertension. However, no practical endpoint to determine procedural success during treatment has been established.MethodsA total of 39 ablation lesions were induced in vivo in eight porcine renal arteries and a total of 15 ablation lesions were induced ex vivo in five excised porcine renal arteries with a radiofrequency delivery device. Acute histological changes and appearance on intravascular imaging of the lesions were investigated with light microscopy, transmission electron microscopy, intravascular ultrasound (IVUS), and optical frequency domain imaging (OFDI).ResultsMarked changes were noted in media, adventitia, and perirenal‐arterial nerves immediately after in vivo ablation. Changes visualized on IVUS were characterized by focal adventitial thickening comprising a relatively echogenic layer around a heterogeneously hypoechoic interior region, and on OFDI as disappearance of the external elastic membrane signals with high scattering of signals in the surface layer. The changes after ex vivo ablation were histopathologically identical to those from in vivo ablation. There were statistically significant positive correlations in measured dimensions (area, depth, width, and diameter) of ablation lesions between histopathology and IVUS/OFDI findings (Pearson correlation coefficients = 0.69–0.77).ConclusionsThese findings suggest that observation of treated renal arteries by IVUS or OFDI immediately after RDN improves the success rate of RDN.
Carfilzomib and dexamethasone for extramedullary myeloma with pleuropericardial involvement
Authors: Español Ignacio , Romera Marta , Gutiérrez‐Meca María Dolores , García Maria del Carmen , Tejedor Aurelia , Martínez Antonio , Ibáñez Jerónima , De Arriba Felipe , Minguela Alfredo , Iturbe Teodoro , López Maria Dolores 
Published: June 2017

Key Clinical MessageThe dismal outcome of pleuropericardial extramedullary multiple myeloma (EMM) reflects both the selection of resistant disease and absence of useful drugs. Carfilzomib and dexamethasone should be explored in advanced EMM patients, even for bortezomib‐resistant patients, as may provide much longer overall survival than previously reported treatments.
Urticaria vasculitis in a child: a case report and literature review
Authors: Imbernón‐Moya Adrián , Vargas‐Laguna Elena , Burgos Fernando , Fernández‐Cogolludo Eva , Aguilar‐Martínez Antonio , Gallego‐Valdés Miguel Ángel 
Published: June 2017

Key Clinical MessageAnnular urticarial lesions in a child must establish a main differential diagnosis with urticaria multiforme, common urticaria, acute hemorrhagic edema of infancy, erythema marginatum, erythema annulare centrifugum, annular erythema in childhood, erythema multiforme, Sweet's syndrome, Schönlein‐Henoch purpura, erythematosus lupus, several systemic vasculitis, and serum sickness.
Auto‐Reduction Behavior of Cobalt on Graphitic Carbon Nitride Coated Alumina Supports for Fischer–Tropsch Synthesis
Authors: Park Hunmin , Kim Kwang Young , Youn Duck Hyun , Choi Yo Han , Kim Won Young , Lee Jae Sung 
Published: June 2017

AbstractGraphitic carbon nitride (g‐C3N4)‐coated alumina (CN‐Al) is investigated as a support material for a cobalt‐based Fischer–Tropsch synthesis (FTS) catalyst. The g‐C3N4 blocks the interaction between cobalt and alumina to hinder the formation of irreducible cobalt oxide species, and improves the dispersion of metallic cobalt species on the CN‐Al support. Furthermore, the coated g‐C3N4 is decomposed during the pre‐annealing process even under inert conditions to evolve reductive carbon monoxide gas that directly reduces the cobalt oxide species to metallic cobalt. Hence, the catalyst can be activated without typical hydrogen pretreatment. Moreover, reduction promotion by expensive noble metals such as Pt is not needed either. Because of the improved dispersion and reducibility of the cobalt species on the CN‐Al support, the catalytic FTS activity of Co/CN‐Al is higher compared with the conventional Co/Al2O3 catalyst.
Electrocatalytic Properties of Cuprous Delafossite Oxides for the Alkaline Oxygen Reduction Reaction
Authors: Draskovic Thomas I. , Wu Yiying 
Published: June 2017

AbstractInspired by the oxygen‐binding copper sites in biomolecules, a series of cuprous delafossite oxides (CuBO2; B=Sc, Y, La) with similar interatomic copper distances were utilized as electrocatalysts for the oxygen reduction reaction (ORR). The carbon‐supported oxides showed improved onset potential, current, and electron‐transfer number over carbon black, with CuLaO2 having the highest prevalence of the complete four‐electron reduction. The oxygen electrocatalytic activity of the copper site in delafossite oxides was demonstrated.
Thermal Conductivity Measurement of Bulk Solids
Authors: Hlosta Jakub , Zurovec David , Gelnar Daniel , Zegzulka Jiri , Necas Jan 
Published: June 2017

AbstractThe coefficient of thermal conductivity of particulates and powders is of great importance in process engineering. The prediction of thermal properties of powders using empirical equations is still difficult due to the wide range of specific attributes. This article describes a new measurement methodology for a laboratory device that can be used to determine the thermal conductivity of bulk solids. The presented results show that the created device is highly applicable in industrial practice. It is possible to examine the coefficient of thermal conductivity depending on the sample temperature, the granulometry results and the morphological composition, the moisture content, the degree of consolidation, and other variables that may enter into the entire process and affect it significantly.
Catalytic Enantioselective Michael Addition Reactions of Tertiary Enolates Generated by Detrifluoroacetylation
Authors: Zhu Yi , Zhang Wenzhong , Mei Haibo , Han Jianlin , Soloshonok Vadim A. , Pan Yi 
Published: June 2017

AbstractThis work describes, for the first time, Michael addition reactions of tertiary fluoro‐enolates in situ generated by detrifluoroacetylation with 1‐(1‐(phenylsulfonyl) vinylsulfonyl)benzene. Excellent enantioselectivity and chemical yields were achieved with application of catalysts (10 mol %) derived from Cu(OTf)2 and (1S,2S)‐1,2‐diphenylethane‐1,2‐diamine. These reactions show a considerable degree of structural generality and allow the preparation of new types of biologically relevant molecules that contain quaternary C−F stereogenic carbon atoms and feature five‐, six‐, or seven‐membered rings as well as heterocyclic 3‐fluoro‐2,3‐dihydrochromen‐4‐one moieties.
Triplet Harvesting with a Simple Aromatic Carbonyl
Authors: Torres Ziegenbein Christian , Fröbel Sascha , Glöß Maria , Nobuyasu Roberto S. , Data Przemyslaw , Monkman Andrew , Gilch Peter 
Published: June 2017

AbstractThe efficiency of organic light‐emitting diodes crucially depends on triplet harvesters. These accept energy from triplet correlated electron hole pairs and convert it into light. Here, experimental evidence is given that simple aromatic carbonyls, such as thioxanthone, could serve this purpose. In these compounds, the emissive 1ππ* excitation may rapidly equilibrate with an upper triplet state (3nπ*). This equilibrium may persist for nanoseconds. Population of the 3nπ* state via energy transfer from an electron hole pair should result in fluorescence emission and thereby triplet harvesting. To demonstrate the effect, solutions of 1,4‐dichlorobenzene (triplet sensitizer) and thioxanthone (harvester) were excited at 266 nm with a nanosecond laser. The emission decay reveals a 100 ns decay absent in the thioxanthone only sample. This matches predictions for an energy transfer limited by diffusion and gives clear evidence that thioxanthone can convert triplet excitations into light.
Multilayer N‐doped Graphene Films as Photoelectrodes for H2 Evolution
Authors: Garcia Alejandra , Albero Josep , García Hermenegildo 
Published: June 2017

AbstractMultilayer N‐doped graphene photoelectrodes have been prepared following a straightforward one‐step pyrolytic fabrication method. The N‐doped graphene photoelectrodes have been demonstrated to work both as semitransparent electrodes and as efficient photoelectrocatalysts for H2 evolution at low bias. N‐doped graphene photoelectrodes exhibited a constant H2 generation rate of 3.64 μmol h−1 cm2 at 0.2 V under 3443 W m−2 irradiation for 17 h, reaching an applied‐bias‐compensated solar‐to‐hydrogen efficiency of 1.8 %. The N‐doped graphene photoelectrodes show light‐intensity dependence as well as photocatalytic activity for H2 evolution in the UV/Vis spectral region. Impedance spectroscopy provides experimental evidence indicating that charge separation within N‐doped graphene increases upon positive bias polarization of the photoelectrode.
Arthropod communities on hybrid and parental cottonwoods are phylogenetically structured by tree type: Implications for conservation of biodiversity in plant hybrid zones
Authors: Jarvis Karl J. , Allan Gerard J. , Craig Ashley J. , Beresic‐Perrins Rebecca K. , Wimp Gina , Gehring Catherine A. , Whitham Thomas G. 
Published: June 2017

AbstractAlthough hybridization in plants has been recognized as an important pathway in plant speciation, it may also affect the ecology and evolution of associated communities. Cottonwood species (Populus angustifolia and P. fremontii) and their naturally occurring hybrids are known to support different plant, animal, and microbial communities, but no studies have examined community structure within the context of phylogenetic history. Using a community composed of 199 arthropod species, we tested for differences in arthropod phylogenetic patterns within and among hybrid and parental tree types in a common garden. Three major patterns emerged. (1) Phylogenetic diversity (PD) was significantly different between arthropod communities on hybrids and Fremont cottonwood when pooled by tree type. (2) Mean phylogenetic distance (MPD) and net relatedness index (NRI) indicated that communities on hybrid trees were significantly more phylogenetically overdispersed than communities on either parental tree type. (3) Community distance (Dpw) indicated that communities on hybrids were significantly different than parental species. Our results show that arthropod communities on parental and hybrid cottonwoods exhibit significantly different patterns of phylogenetic structure. This suggests that arthropod community assembly is driven, in part, by plant–arthropod interactions at the level of cottonwood tree type. We discuss potential hypotheses to explain the effect of plant genetic dissimilarity on arthropod phylogenetic community structure, including the role of competition and environmental filtering. Our findings suggest that cottonwood species and their hybrids function as evolutionarily significant units (ESUs) that affect the assembly and composition of associated arthropod communities and deserve high priority for conservation.
In situ Detection of Microplastics: Single Microparticle‐electrode Impacts
Authors: Shimizu Kenichi , Sokolov Stanislav V. , Kätelhön Enno , Holter Jennifer , Young Neil P. , Compton Richard G. 
Published: June 2017

AbstractParticle‐impact electrochemistry is employed to study spherical polyethylene microparticles suspended in an aqueous solution. This electrochemical method detects polyethylene microparticles impacting on a carbon fiber electrode generating a transient current response or “spike”. We interpret the physio‐chemical origin of the spikes and accurately identify particle size distributions and concentrations for microparticles of sizes 1–10 μm.
Cell specificity of magnetic cell seeding approach to hydrogel colonization
Authors: Singh Raminder , Wieser Anna , Reakasame Supachai , Detsch Rainer , Dietel Barbara , Alexiou Christoph , Boccaccini Aldo R. , Cicha Iwona 
Published: June 2017

AbstractTissue‐engineered scaffolds require an effective colonization with cells. Superparamagnetic iron oxide nanoparticles (SPIONs) can enhance cell adhesion to matrices by magnetic cell seeding. We investigated the possibility of improving cell attachment and growth on different alginate‐based hydrogels using fibroblasts and endothelial cells (ECs) loaded with SPIONs. Hydrogels containing pure alginate (Alg), alginate dialdehyde crosslinked with gelatin (ADA‐G) and Alg blended with G or silk fibroin (SF) were prepared. Endothelial cells and fibroblasts loaded with SPIONs were seeded and grown on hydrogels for up to 7 days, in the presence of magnetic field during the first 24 h. Cell morphology (fluorescent staining) and metabolic activity (WST‐8 assay) of magnetically‐seeded versus conventionally seeded cells were compared. Magnetic seeding of ECs improved their initial attachment and further growth on Alg/G hydrogel surfaces. However, we did not achieve an efficient and stable colonization of ADA‐G films with ECs even with magnetic cell seeding. Fibroblast showed good initial colonization and growth on ADA‐G and on Alg/SF. This effect was further significantly enhanced by magnetic cell seeding. On pure Alg, initial attachment and spreading of magnetically‐seeded cells was dramatically improved compared to conventionally‐seeded cells, but the effect was transient and diminished gradually with the cessation of magnetic force. Our results demonstrate that magnetic seeding improves the strength and uniformity of initial cell attachment to hydrogel surface in cell‐specific manner, which may play a decisive role for the outcome in tissue engineering applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2948–2956, 2017.
Regulation of the fate of dental‐derived mesenchymal stem cells using engineered alginate‐GelMA hydrogels
Authors: Ansari Sahar , Sarrion Patricia , Hasani‐Sadrabadi Mohammad Mahdi , Aghaloo Tara , Wu Benjamin M , Moshaverinia Alireza 
Published: June 2017

AbstractMesenchymal stem cells (MSCs) derived from dental and orofacial tissues provide an alternative therapeutic option for craniofacial bone tissue regeneration. However, there is still a need to improve stem cell delivery vehicles to regulate the fate of the encapsulated MSCs for high quality tissue regeneration. Matrix elasticity plays a vital role in MSC fate determination. Here, we have prepared various hydrogel formulations based on alginate and gelatin methacryloyl (GelMA) and have encapsulated gingival mesenchymal stem cells (GMSCs) and human bone marrow MSCs (hBMMSCs) within these fabricated hydrogels. We demonstrate that addition of the GelMA to alginate hydrogel reduces the elasticity of the hydrogel mixture. While presence of GelMA in an alginate‐based scaffold significantly increased the viability of encapsulated MSCs, increasing the concentration of GelMA downregulated the osteogenic differentiation of encapsulated MSCs in vitro due to decrease in the stiffness of the hydrogel matrix. The osteogenic suppression was rescued by addition of a potent osteogenic growth factor such as rh‐BMP‐2. In contrast, MSCs encapsulated in alginate hydrogel without GelMA were successfully osteo‐differentiated without the aid of additional growth factors, as confirmed by expression of osteogenic markers (Runx2 and OCN), as well as positive staining using Xylenol orange. Interestingly, after two weeks of osteo‐differentiation, hBMMSCs and GMSCs encapsulated in alginate/GelMA hydrogels still expressed CD146, an MSC surface marker, while MSCs encapsulated in alginate hydrogel failed to express any positive staining. Altogether, our findings suggest that it is possible to control the fate of encapsulated MSCs within hydrogels by tuning the mechanical properties of the matrix. We also reconfirmed the important role of the presence of inductive signals in guiding MSC differentiation. These findings may enable the design of new multifunctional scaffolds for spatial and temporal control over the fate and function of stem cells even post‐transplantation. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2957–2967, 2017.
Titanium‐released from dental implant enhances pre‐osteoblast adhesion by ROS modulating crucial intracellular pathways
Authors: Rossi M. C. , Bezerra F. J. B. , Silva R. A. , Crulhas B. P. , Fernandes C. J. C. , Nascimento A. S. , Pedrosa V. A. , Padilha P. , Zambuzzi W. F. 
Published: June 2017

AbstractIt is important to understand the cellular and molecular events that occur at the cell–material interface of implants used for bone repair. The mechanisms involved in the initial stages of osteoblast interactions with the surface of the implant material must be decisive for cell fating surrounding them. In order to address this issue, we decided to investigate if conditioned medium for dental implants was able to modulate murine pre‐osteoblast metabolism. First, we determined the concentration of titanium (Ti)‐containing conditioned medium and found that it was 2‐fold increased (p < 0.0001). We have reported that this conditioned medium significantly up‐modulated pre‐osteoblast adhesion up to 24 h (p < 0.0001). In parallel, our results showed that both phosphorylations of FAK (focal adhesion kinase) at Y397 (p < 0.0011) and Cofilin at Ser03 (p < 0.0053) were also up‐modulated, as well as for Rac1 expression (p < 0.0175); both of them are involved with cell adaptation by rearranging cytoskeleton actin filaments. Thereafter, Ti‐containing medium stimulated ROS (reactive oxygen species) production by pre‐osteoblast cells, and it is very possible that ROS compromised PTP‐1B (protein tyrosine phosphatase 1B) activation since PTP1B was down‐phosphorylated (p < 0.0148). The low PTP activity guarantees the phosphorylation of FAK at Y‐residue, causing better pre‐osteoblast adhesion in response to Ti‐containing medium. Altogether, these data indicate that ROS indirectly modulate FAK phosphorylation in response to Ti‐released from dental implants. Taken the results in account, these data showed for the first time that the implanted dental device is able to dynamically affect surrounding tissues, mainly by promoting a better performance of the pre‐osteoblast cells. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2968–2976, 2017.
Nonimmediate allergic reactions induced by Mesna
Authors: Shimogori Kei , Araki Makoto , Shibazaki Shunichi , Tuda Katuji , Miura Kohei 
Published: June 2017

AbstractMesna (2‐mercaptoethane sulfonate Na), a drug that alleviates cyclophosphamide (CYC)‐induced hemorrhagic cystitis, is frequently used to treat cancer and collagen diseases. A 33‐year‐old woman presented with high fever during CYC‐based induction therapy for systemic lupus erythematosus. Her final diagnosis was mesna‐induced drug hypersensitivity. Although mesna is widely used, allergic reactions are rare. This may be because of misdiagnosis as a primary disease flare‐up, infection, or CYC‐induced hypersensitivity reaction, which are commonly reported. Thus, accurate diagnosis is important for completion of the CYC‐based regimen.
Two‐step irradiance schedule versus single‐dose cold compress for pain control during 5‐aminolevulinic acid‐based photodynamic therapy of condyloma acuminatum
Authors: Shao Xiaonan , Wang Fang , Xu Bin 
Published: June 2017

ObjectiveThe purpose of this study was to investigate the effect of two‐step irradiance schedule in relieving pain during PDT of CA.MethodsThe study was a prospective, controlled trial of 141 CA patients who were randomly divided into Group A (two‐step irradiance schedule) and Group B (single‐dose cold compress). The numeric rating scales (NRS) of patients’ pain were recorded at 5, 10, 15, and 20 minutes during each PDT.ResultsThe efficacy of PDT and NRS scores of patients in the two groups were compared. There was no significant difference in gender, age, lesion site, and disease course between the two groups (P > 0.05). In addition, the cure rate of patients in the two groups was not significantly different (97.1% vs. 95.8%, χ2 = 0.000, P = 1.000). However, the NRS scores at different time points and number of PDT sessions were significantly different (F = 198.233 and 165.224, respectively, P < 0.05). The NRS scores of patients in Group A were significantly lower than those of patients in Group B (F = 82.762, P < 0.0001). Moreover, the NRS scores at different positions were significantly different (F = 28.286, P < 0.0001). The NRS scores of penis were significantly lower than those of the vulva and crissum (P < 0.05).ConclusionsCompared with single‐dose cold compress, two‐step irradiance schedule could more significantly reduce the patients’ pain degree during treatment, especially for vulva and crissum. Lasers Surg. Med. 49:908–912, 2017. © 2017 Wiley Periodicals, Inc.