bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory T Cells in Melanoma Revisited by a Computational Clustering of FOXP3+ T Cell Subpopulations
Authors: Fujii Hiroko , Josse Julie , Tanioka Miki , Miyachi Yoshiki , Husson François , Ono Masahiro 
Published: February 2016

Abstract
CD4+ T cells that express the transcription factor FOXP3 (FOXP3+ T cells) are commonly regarded as immunosuppressive regulatory T cells (Tregs). FOXP3+ T cells are reported to be increased in tumor-bearing patients or animals and are considered to suppress antitumor immunity, but the evidence is often contradictory. In addition, accumulating evidence indicates that FOXP3 is induced by antigenic stimulation and that some non-Treg FOXP3+ T cells, especially memory-phenotype FOXP3low cells, produce proinflammatory cytokines. Accordingly, the subclassification of FOXP3+ T cells is fundamental for revealing the significance of FOXP3+ T cells in tumor immunity, but the arbitrariness and complexity of manual gating have complicated the issue. In this article, we report a computational method to automatically identify and classify FOXP3+ T cells into subsets using clustering algorithms. By analyzing flow cytometric data of melanoma patients, the proposed method showed that the FOXP3+ subpopulation that had relatively high FOXP3, CD45RO, and CD25 expressions was increased in melanoma patients, whereas manual gating did not produce significant results on the FOXP3+ subpopulations. Interestingly, the computationally identified FOXP3+ subpopulation included not only classical FOXP3high Tregs, but also memory-phenotype FOXP3low cells by manual gating. Furthermore, the proposed method successfully analyzed an independent data set, showing that the same FOXP3+ subpopulation was increased in melanoma patients, validating the method. Collectively, the proposed method successfully captured an important feature of melanoma without relying on the existing criteria of FOXP3+ T cells, revealing a hidden association between the T cell profile and melanoma, and providing new insights into FOXP3+ T cells and Tregs.
Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity
Authors: Krummey Scott M. , Martinez Ryan J. , Andargachew Rakieb , Liu Danya , Wagener Maylene , Kohlmeier Jacob E. , Evavold Brian D. , Larsen Christian P. , Ford Mandy L. 
Published: February 2016

Abstract
Heterologous immunity is recognized as a significant barrier to transplant tolerance. Whereas it has been established that pathogen-elicited memory T cells can have high or low affinity for cross-reactive allogeneic peptide–MHC, the role of TCR affinity during heterologous immunity has not been explored. We established a model with which to investigate the impact of TCR-priming affinity on memory T cell populations following a graft rechallenge. In contrast to high-affinity priming, low-affinity priming elicited fully differentiated memory T cells with a CD45RBhi status. High CD45RB status enabled robust secondary responses in vivo, as demonstrated by faster graft rejection kinetics and greater proliferative responses. CD45RB blockade prolonged graft survival in low affinity–primed mice, but not in high affinity–primed mice. Mechanistically, low affinity–primed memory CD8+ T cells produced more IL-2 and significantly upregulated IL-2Rα expression during rechallenge. We found that CD45RBhi status was also a stable marker of priming affinity within polyclonal CD8+ T cell populations. Following high-affinity rechallenge, low affinity–primed CD45RBhi cells became CD45RBlo, demonstrating that CD45RB status acts as an affinity-based differentiation switch on CD8+ T cells. Thus, these data establish a novel mechanism by which CD45 isoforms tune low affinity–primed memory CD8+ T cells to become potent secondary effectors following heterologous rechallenge. These findings have direct implications for allogeneic heterologous immunity by demonstrating that despite a lower precursor frequency, low-affinity priming is sufficient to generate memory cells that mediate potent secondary responses against a cross-reactive graft challenge.
Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia
Authors: Samuelson Derrick R. , de la Rua Nicholas M. , Charles Tysheena P. , Ruan Sanbao , Taylor Christopher M. , Blanchard Eugene E. , Luo Meng , Ramsay Alistair J. , Shellito Judd E. , Welsh David A. 
Published: February 2016

Abstract
Pneumocystis pneumonia is a major cause of morbidity and mortality in immunocompromised patients, particularly those infected with HIV. In this study, we evaluated the potential of oral immunization with live Pneumocystis to elicit protection against respiratory infection with Pneumocystis murina. C57BL/6 mice vaccinated with live P. murina using a prime-boost vaccination strategy were protected from a subsequent lung challenge with P. murina at 2, 7, 14, and 28 d postinfection even after CD4+ T cell depletion. Specifically, vaccinated immunocompetent mice had significantly faster clearance than unvaccinated immunocompetent mice and unvaccinated CD4-depleted mice remained persistently infected with P. murina. Vaccination also increased numbers of CD4+ T cells, CD8+ T cells, CD19+ B cells, and CD11b+ macrophages in the lungs following respiratory infection. In addition, levels of lung, serum, and fecal P. murina–specific IgG and IgA were increased in vaccinated animals. Furthermore, administration of serum from vaccinated mice significantly reduced Pneumocystis lung burden in infected animals compared with control serum. We also found that the diversity of the intestinal microbial community was altered by oral immunization with P. murina. To our knowledge, our data demonstrate for the first time that an oral vaccination strategy prevents Pneumocystis infection.
PATIENTS REFERRED FOR BLEEDING SYMPTOMS OF UNKNOWN CAUSE: DOES EVALUATION OF THROMBIN GENERATION CONTRIBUTE TO DIAGNOSIS?
Authors: Holm Elena , Zetterberg Eva , Lövdahl Susanna , Berntorp Erik 
Published: February 2016

IntroductionPatients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms. Global coagulation assays, e.g., the thrombin generation test (thrombogram) have a potential to identify hemostatic defects that are not detected in specific assays.Material and MethodsOne hundred and eighty-five patients referred to our centre because of bleeding symptoms were evaluated using the bleeding assessment tool (BAT) described by Tosetto and colleagues in 2006. Blood samples were investigated for thrombin generation (TG) capacity (Technoclone) , in platelet poor (PPP) plasma , and specific clotting factors, i.e, von Willebrand factor, factor VIII and IX, as well as INR, APTT, platelet count, and platelet adhesion.ResultsOf the 185 patients, five women were diagnosed with mild von Willebrand disease and one male with mild hemophilia A. The remaining 179 subjects (76% females and 24% males with average ages of 33 and 28 years, respectively) were evaluated further. In the total cohort and among women, peak TG, and lag time correlated with bleeding score (p=0.01 and p=0.04, respectively with correlation coefficients). No such correlations were found among males. Discussion and conclusion Although our study showed some correlation between TG and bleeding score, results are generally consistent with a previous report which failed to demonstrate the value of TG measurement in a similar setting. In conclusion, the complexity of the mechanisms underlying clinical bleeding complicates the ability to use TG tests as reliable predictors of bleeding. Mild congenital bleeding disorders, especially VWD, should be specifically screened for in patients with mild/moderate symtoms.
Functional Rehabilitation Following TBI: An Analysis of Inpatient Recovery and Community Integration
Authors: Weaver Jennifer , Lucero Mariano , Hewett Marie , Kersey Jessica , Esmaeili Keyvan , Wheeler Steven 
Published: February 2016

Abstract
Date Presented 4/16/2015
This poster presentation details the results of a longitudinal study on recovery from traumatic brain injury (TBI) both during and after interdisciplinary functional rehabilitation. Outcome variables include client functioning and self-reported life satisfaction as well as postdischarge caregiver burden.
Occupational Therapy and Autism Spectrum Disorder: A Scoping Review of 70 Years of Literature
Authors: Bagatell Nancy , Mason Ashley 
Published: February 2016

Abstract
Date Presented 4/16/2015
A scoping review of 108 articles about autism spectrum disorders from occupational therapy journals was completed to identify trends over the span of 70 yr. The findings illuminate areas for future research and practice to more fully meet the occupational needs of individuals with autism spectrum disorder.
Establishing Conditioned Place Preference in Typically Developing Children
Authors: Thompson Barbara L. , Hiller Leah 
Published: February 2016

Abstract
Date Presented 4/16/2015
Conditioned place preference (CPP) is used to probe differences in reward, motivation, and aversion in children. This is the first attempt to establish CPP in children, and it will help us to understand social and affective processing in children with and without neurodevelopmental disorders.
A Cross-Sectional Study Comparing the Usability of Two Automated Teller Machines Across Diverse User Groups
Authors: Perez Brittany , Lenker James , Steinfield Ed , Subryan Heamchand , Salmeri Marisa , Reedy Timothy , Thomas Mollee 
Published: February 2016

Abstract
Date Presented 4/16/2015
This presentation reports results of a study in which three automated teller machine interfaces were evaluated with four diverse participant groups. The outcome measures included observed and self-reported usability measures. The results across the four groups were compared and contrasted.
Animal-Assisted Therapy: Motives and Rewards
Authors: Vroman Kerryellen , Collins Kailee 
Published: February 2016

Abstract
Date Presented 4/16/2015
Animal-assisted therapists have specific motives that inspire involvement in therapy and have specific rewards that promote continuation. Through understanding these motives and rewards, occupational therapists can work with animal-assisted therapists to create client-centered interventions. Diversifying the field of occupational therapy with the inclusion of animal-assisted therapy would benefit clients, therapists, and the profession. This study is the first to look at the motives of animal-assisted therapists.
Afferent Stimulation via Glove Electrode With Task Specific Training Improves Function and Activity in Chronic Stroke
Authors: Hansen Piper , Girardi Madeline , Hensley Melissa , Rohaus Jordan , Schewe Clay , Whittey Colby , Muir Kim , Sullivan Jane E. 
Published: February 2016

Abstract
Date Presented 4/16/2015
Combining task-specific training with afferent stimulation delivered via glove electrode in individuals with chronic stroke may result in changes at the arm sensation and function. Improvements were maintained at 3-mo follow-up.
Sensory-Adapted Dental Environments: Oral Care in Children With Autism Spectrum Disorder
Authors: Cermak Sharon A. , Stein Leah I. , Polido Jose C. , Williams Marian E. , Dawson Michael E. , Lane Christianne J. 
Published: February 2016

Abstract
Date Presented 4/16/2015
Oral health is integral to well-being. The purpose of this study was to describe the innovative sensory-adapted dental environment and examine its efficacy in children with autism spectrum disorder (ASD) and typically developing children aged 6 to 12 yr. Occupational therapists should be part of the multidisciplinary team to address oral health challenges in children.
A Retrospective Pretest/Posttest Study of Occupational Therapy Intervention for Children With Sensory Challenges
Authors: Flanagan Joanne , Hampton Shannon R. , Sullivan Jillian , Miller Lucy Jane , Schoen Sarah 
Published: February 2016

Abstract
Date Presented 4/16/2015
This study provides preliminary evidence for the effectiveness of a sensory and relationship-based, intensive occupational therapy program in which direct treatment is paired with parent education and coaching, thus advancing evidence-based practice.
Validation and Clinical Applications of a Measurement Model for Upper-Extremity Function
Authors: Hong Ickpyo , Li Chih-Ying (Cynthia) , Velozo Craig A. 
Published: February 2016

Abstract
Date Presented 4/16/2015
A measurement model with two constructs (weight of objects and distance from the floor) explained 83% of the variance (p &lt; .01) for the challenging levels of the gross upper-extremity (GUE) measure of the International Classification of Functioning, Disability and Health (ICF; World Health Organization, 2001). This finding suggests a possible underlying measurement model for upper-extremity function.
Effectiveness of Pairing Sensory and Social Skills Instruction to Improve the Social Participation of Children With Autism Spectrum Disorder (ASD)
Authors: McLaughlin Ellen , Charney Lori 
Published: February 2016

Abstract
Date Presented 4/16/2015
Pairing social and sensory activities can be a useful intervention for children with autism spectrum disorder (ASD), resulting in improved generalization in the natural social environment. Improvement in social competence of the individual will encourage peer acceptance and development of positive peer relationships.
Differences in the Hand Force Requirements of Women With Hand Arthritis When Opening Jars With and Without Joint Protection Strategies
Authors: McGee Cory W. 
Published: February 2016

Abstract
Date Presented 4/16/2015
Joint protection for hand osteoarthritis (OA) relies on theory but not empirical evidence. This study focuses on how hand positioning and nonskid materials influence forces, pain, and perceived effort during jar opening. New data challenge the belief that nonskid materials alone reduce hand forces.
Supporting Safety for Prebariatric Surgery Candidates: Effects of Obesity and Degenerative Joint Disease on Movement
Authors: Woo Nicole , Xia Pu , Gill Simone V. 
Published: February 2016

Abstract
Date Presented 4/16/2015
Obesity and knee degenerative joint disease affect clients’ mobility and participation. The influence of body structures on mobility for clients undergoing bariatric surgery was examined in this study. Occupational therapists have the expertise to create client-centered, occupation-based interventions to reduce clients’ fall risks.
Perspectives of Older Women on Toileting
Authors: Aguilar Elvira Moya , O’Neal Amanda Layne , Holz Oliva M. , Fox Krista Anita , Foley Kathleen T. 
Published: February 2016

Abstract
Date Presented 4/16/2015
Deficits in self-care have been linked to older adults’ ability to remain at home; little research has focused on toileting. In this qualitative study, we used interviews to explore attitudes, experiences, practices, and preferences associated with toileting by older women. Results will inform the development of client-centered interventions to maximize performance and to support aging in place.
Validation of the Participation Strategies Self-Efficacy Scale (PS–SES)
Authors: Lee Danbi 
Published: February 2016

Abstract
Date Presented 4/16/2015
The newly developed, reliable Participation Strategies Self-Efficacy Scale (PS–SES) is introduced. The tool is designed to assess self-efficacy in using strategies to actively manage participation in home, community, and work following a stroke.
How Occupational Therapists Develop, Maintain, and Sustain Global Partnerships: A Qualitative Study
Authors: Kerrigan Kaitlyn , Grabowski Lauren , Watts Alexandra , Bowers Katherine , Hansen Anne Marie Witchger 
Published: February 2016

Abstract
Date Presented 4/16/2015
Future commitment to international occupational therapy for a global profession requires more understanding of the successful ways in which a global partnership is developed. This study provides strategies for how occupational therapists can be of best service to the global community they are working in.
Therapist Perceptions of the Utility of Sonographic Imaging in the Rehabilitation of Musculoskeletal Disorders
Authors: Roll Shawn , Gray Julie McLaughlin , Frank Geyla , Wolkoff Monique 
Published: February 2016

Abstract
Date Presented 4/16/2015
Sonography is a relatively inexpensive imaging modality that provides real-time, dynamic views of anatomical structures. This session will discuss the results of a qualitative descriptive study that revealed a wide range of uses for sonography by occupational therapists.
Implications for Occupational Therapy Practice: Does Botulinum Toxin Decrease Pain and Lessen Disability in the Hemiplegic Shoulder?
Authors: Bravi Lori , Polo Katie 
Published: February 2016

Abstract
Date Presented 4/16/2015
This report describes a randomized, double-blinded, placebo-controlled trial examining the efficacy of shoulder Botox® injections for reducing pain, impairment, and disability. Implications for occupational therapy practice are highlighted for best patient outcomes of the adult stroke survivor.
Evidence-Based Literature Review on Fatigue Management and Adults With Multiple Sclerosis
Authors: Yu Chih-Huang , Mathiowetz Virgil 
Published: February 2016

Abstract
Date Presented 4/16/2015
This review found strong evidence that group fatigue management education is effective for persons with multiple sclerosis while finding no evidence supporting the individual format. These results have the potential to change practice and demonstrate the need for research on the individual format.
Factors That Affect the Retirement Transition for the Baby Boomer Generation and Implications for Occupational Therapy
Authors: VanOoyen Courtney , Grapczynski Cynthia A. , Renter Heather M. , Sisco William , Liebknecht Julie , Doherty Kelly 
Published: February 2016

Abstract
Date Presented 4/16/2015
The review includes the identification of factors that affect the retirement transition for the baby boomer generation and implications for the field of occupational therapy in this novel practice area, such as opportunities to collaborate with these clients to increase quality of life and wellness.
Blending Video Games and Cognitive Strategies to Improve Motor Performance in Autism Spectrum Disorders
Authors: Skowronski Jordan , Engsberg Jack 
Published: February 2016

Abstract
Date Presented 4/17/2015
This study furthered an initial protocol in which the Cognitive Orientation to Occupational Performance Approach (CO–OP) was blended with virtual reality. Blending the two may be synergistic and may better meet the specific motor needs of children with autism spectrum disorder. Views from a group of clinicians were assembled, and these views guided protocol refinement. The protocol is ready for pilot testing.
Engaging University Students With Learning Disabilities in Targeting Individual- and Institutional-Level Change
Authors: Kreider Consuelo M. , Delisle Anthony , Wu Chang-Yu , Percival Sue , Lan Mei-Fang , Stenberg Mary Anne , Mann William 
Published: February 2016

Abstract
Date Presented 4/17/2015
Principles of community-engaged research are used to discover and address personal- and environmental-level concerns of university students with learning disabilities for the purpose of facilitating individual action and targeting institutional changes most important to participants.
Use of Exergaming to Improve Physical and Mental Fitness for Children With Autism Spectrum Disorders
Authors: Collins Diane , Attal Allison , Hilton Claudia 
Published: February 2016

Abstract
Date Presented 4/17/2015
This presentation describes findings of improved response speed, executive function, and motor skills in a pilot study examining the effects of participating in the Makoto Arena (an exergame) on 17 high-functioning, school-age children with autism spectrum disorder.
Heading in the Right Direction: Understanding Head Turn Preference in the Preterm Infant
Authors: Dunsirn Sonya , Smyser Chris , Liao Steve , Inder Terrie , Pineda Roberta 
Published: February 2016

Abstract
Date Presented 4/17/2015
Head turn preference in the preterm infant is not associated with medical factors in the neonatal intensive care unit (NICU); however, it is associated with early neurobehavior and asymmetric movement patterns, and it is also a marker for adverse developmental outcome at age 2 yr.
Home Health Professionals’ Encounters With Hoarders
Authors: Dorne Rachelle , Whitehead Diane , Ito Max A. 
Published: February 2016

Abstract
Date Presented 4/17/2015
This study of home health professionals’ encounters with hoarders provides preliminary data and insight into hoarding in Florida. These findings will help occupational therapists (OTs) and interprofessional teams working with hoarders to develop programs, assessment tools, and interventions to improve services to hoarders.
Readability Levels of Traumatic Brain Injury Websites in Australia, New Zealand, the United Kingdom, and the United States
Authors: Thomas Julie Jepsen , Veith Heather 
Published: February 2016

Abstract
Date Presented 4/17/2015
This study investigated the readability of international traumatic brain injury (TBI) websites. Results show that they are written at grade levels that exceed the literacy of many of those with TBI and a large portion of the general population. Suggestions to enhance readability of website and nonwebsite sources are described.
Evaluation of Optimal Proximal Interphalangeal (PIP) Joint Fusion Angle Using Simulated Joint Arthrodesis
Authors: DeChello Karen , Lider Yevheniy , Fourman Mitchell , Arjun Iyer , Sue Sisto , Dagum Alexander 
Published: February 2016

Abstract
Date Presented 4/17/2015
In this study, we aim to identify an optimal proximal interphalangeal (PIP) fusion angle that will preserve pinch strength and dexterity as well as maximize performance in daily functional activities. Study results will facilitate better occupational therapy treatment outcomes and occupational performance.
Learning Styles as Predictors of Fieldwork Performance and Adaptability of Graduate Occupational Therapy Students
Authors: Velis Evelio , Greg Katherine , Landa-Gonzalez Belkis 
Published: February 2016

Abstract
Date Presented 4/17/2015
This retrospective, mixed-methods study assessed the learning styles, relationship to fieldwork performance, and learning adaptability of graduate, nontraditional occupational therapy students. Implication of findings for teaching, self-regulated learning, and fieldwork are discussed.
Investigating the Effect of Caregiver Height and Body Mass Index When Completing a Pivot Transfer
Authors: Christman Dawn , Rice Martin S. , Gray Richelle 
Published: February 2016

Abstract
Date Presented 4/17/2015
This study investigates the forces required when transferring a patient using different caregiver physical heights and body mass indexes (BMI) combined with different patient heights and BMIs. Results may lead to better clinical reasoning when handling patients.
Relationship of Undergraduate Grade Point Average (GPA) and Graduate Record Examination Scores With Level II Fieldwork Performance
Authors: Haber Alaena , Fen Allie , Perrine Katherine , Jin Jessica , Bathje Molly , Ozelie Rebecca 
Published: February 2016

Abstract
Date Presented 4/17/2015
Admission into occupational therapy programs is an increasingly competitive process. It is important for programs to be strategic in admitting students who will be successful in both academic and clinical requirements. The results of the study may provide an evidence-based rationale for selecting applicants.
The Effects of Low-Cost, Adapted Ride-on-Toys: A Case Series With Toddlers With Neuromuscular Disorders
Authors: Spain Heather , Kraft Sara , Anson Carrie , Wagor Chelsea , Futrell Natalie , Coker-Bolt Patty 
Published: February 2016

Abstract
Date Presented 4/17/2015
This study investigated early power mobility using adapted ride-on-toys in toddlers with disabilities. Improvements were seen in cognitive, social, and self-care domains on standardized measures. Early power mobility using adapted ride-on-toys may yield positive changes in key areas of development.