bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vivir en situación de calle como problema de salud pública. Una lectura desde la salud mental comunitaria
Authors: Di Iorio Jorgelina 
Published: September 2024

La situación de calle se configura como un campo de problemas complejo de salud pública global, que se expresa en las heterogeneidades de contextos situados. Es decir, las condiciones afectivas, sociales, geográficas y materiales de existencia en la que se despliega la vida cotidiana de quienes experimentan alguna de las múltiples formas en las que se institucionaliza la situación de calle en América Latina y el Caribe, implica la exposición a un conjunto de situaciones específicas que generan malestares y posibles afectaciones físicas y psicosociales, a la vez que formas de hacer frente a dichas afectaciones. Constituye una de las formas en las que se institucionalizan los procesos de vulnerabilización y expulsión social, particularmente en contextos urbanos.
Dispositivos habitacionales: una reflexión sobre la doble dimensión Casa/Dispositivo en un Servicio de Externación de un Hospital Psiquiátrico de la Provincia de Buenos Aires
Authors: Oliveira Ana Claudia 
Published: September 2024

Introducción: Los dispositivos habitacionales son dispositivos con orientación comunitaria de inclusión socio-habitacional, complementario de la atención en salud. Proponen acompañar los procesos de externación de personas usuarias que estuvieron largamente institucionalizadas en hospitales psiquiátricos. El objetivo de este trabajo es caracterizar la doble dimensión Casa/Dispositivo en un dispositivo de apoyo a la vivienda de la Provincia de Buenos Aires en el año 2021.
Materiales y métodos: Fueron realizadas entrevistas a 2 (dos) profesionales de salud mental que actúan en dispositivos habitacionales. El material fue analizado a partir de las categorías de análisis Casa y Dispositivo ubicando sus definiciones, así como las diferencias y superposiciones de las mismas. Resultados: Aunque se observa que la doble dimensión es un aspecto característico de dichos dispositivos, la temática no aparece de modo sistematizado en las experiencias de externación investigadas.
Discusión y conclusiones: Las entrevistas indican una congruencia entre los derechos humanos y las garantías plasmadas en la Ley 26.657. Además, cabe reflexionar respecto a la ausencia de políticas públicas habitacionales que ofrezcan recursos para la vida fueradel manicomio.
Salud mental y educación en contextos de encierro: la experiencia del Centro Universitario Devoto
Authors: Henning Bruno 
Published: September 2024

Este trabajo, fruto de una investigación que llevó 6 años y derivó en mi tesis doctoral, emergió a partir del interrogante sobre las relaciones entre el campo de la salud mental, la pedagogía, el sistema penal y la educación en contexto de encierro. Como modo de procurar algunas respuestas a esta inquietud, me propuse describir y analizar de qué forma se vinculan los postulados sobre la salud, el sistema carcelario y la educación en prisión, desde una metodología transdisciplinaria. Para ello, abordé la experiencia del Centro Universitario Devoto (CUD), en general, y las prácticas del Programa de Extensión en Cárceles (PEC), en particular. El Centro Universitario Devoto consiste en la presencia de la Universidad de Buenos Aires (UBA) en la cárcel de Devoto, en Buenos Aires, en el marco del Proyecto UBA XXII, y busca garantizar el derecho a la educación en contexto de encierro punitivo, ya que -supuestamente- el único derecho que perderían las personas privadas de la libertad es el derecho a circular libremente. El Centro Universitario Devoto nació formalmente en 1985, mientras que el Programa de Extensión en Cárceles es un Programa que brinda cursos y talleres extracurriculares, constituido como tal en el año 2011.
Digital transformation of banking: Assessing mobile banking adoption in Nepal
Authors: Lama Padam Bahadur , Subedi Rita Subedi , Lamichhane Basu Dev , Karki Murari , Chalise Sabina 
Published: September 2024

The purpose of study was to investigate the influence of perceived usefulness, perceived security, and perceived cost on behavioral intention to adopt mobile banking, which reflects the evidences from among the users of digital mobile banking services in Kathmandu, Nepal. The study fills a gap in the literature by examining the influencing factors for mobile banking adoption. This study adopted descriptive and casual correlational research design to test the hypotheses. The survey employed cross-sectional data using convenience-sampling technique, disseminated 607-structured questionnaire among the target respondents of Kathmandu municipality, Nepal, and received only 400 (65.89 percent) useful questionnaires. This study assessed the internal consistency with the value of Cronbach’s alpha where the value of Cronbach’s alpha for all constructs remained > 0.70 depicting the reliability for the analysis. Further, this study adopted descriptive statistics: frequency and percentage for the result of general information of respondents and correlation and regression analysis for testing association and impact in the study. The findings of the study showed that perceived usefulness and perceived security found positive association with behavioral intention to adopt mobile banking services, in Kathmandu, Nepal. Further, perceived cost found negative impact on behavioral intention for adoption of mobile banking services indicating inverse link between cost and mobile banking adoption. Thus, banking professionals may use this model to develop safe, practical, and easy-to-use mobile banking services to win trust of users and to boost mobile banking services. Similarly, the findings of the study extends benchmark to academics, policymakers, and others.
Asymptomatic Migration of Ureteral Stent to Superior Vena Cava After Ultrasound-Guided Percutaneous Nephrolithotomy: An Extremely Rare Case and Review of the Literature
Authors: Hassani Amir Hossein , Kamran Hooman , Kojuri Javad , Bazroodi Helia , Fatemian Hossein , Rasekhi Alireza , Naderi Nima , Kooshafar Saeed , Dehghani Anahita , Haghpanah Abdolreza 
Published: September 2024

Abstract

Ureteral stent migration should be considered a rare complication of urologic procedures. We report a 69-year-old lady diagnosed with ureteral stent migration two weeks after undergoing percutaneous nephrolithotomy while she was symptom-free. The stent passed the heart and extended to the superior vena cava and right brachiocephalic vein. After excluding thrombus formation, the stent was retrieved with endovascular approach. Stent migration to superior vena cava while being asymptomatic is extremely rare. Considering this complication is crucial to prevent consequent fatal events. This case highlights this rare complication of ureteral stent placement and reviews its management.
Characterization of language abilities and semantic networks in very preterm children at school-age
Authors: Décaillet Marion , Christensen Alexander P. , Besuchet Laureline , Huguenin-Virchaux Cléo , Fumeaux Céline J. Fischer , Denervaud Solange , Schneider Juliane 
Published: September 2024

Abstract

It has been widely assessed that very preterm children (<32 weeks gestational age) present language and memory impairments compared to full-term children. However, differences in their underlying semantic memory structure have not been studied yet. Nevertheless, the way concepts are learned and organized across development relates to children’s capacities in retrieving and using information later. Therefore, the semantic memory organization could underlie several cognitive deficits existing in very preterm children. Computational mathematical models offer the possibility to characterize semantic networks through three coefficients calculated on spoken language: average shortest path length (i.e., distance between concepts), clustering (i.e., local interconnectivity), and modularity (i.e., vocabulary enrichment). Here we assessed these coefficients in 38 very preterm schoolchildren (aged 8-10 years) compared to 38 full-term schoolchildren (aged 7-10 years) based on a verbal fluency task. Using semantic network analysis, very preterm children showed a longer distance between concepts and a lower interconnectivity at a local level than full-term children. However, we found no differences between very preterm and full-term children regarding their modularity at a global level. These findings provide preliminary evidence that very preterm children demonstrate subtle impairments in the organization of their semantic network, encouraging the adaptation of the support and education they receive.
Dynamic optimization elucidates higher-level pathogenicity strategies of Pseudomonas aeruginosa
Authors: Dimitriew Wassili , Schuster Stefan 
Published: September 2024

Abstract

Pseudomonas aeruginosa is a robust pathogen and possesses many virulence components, including the ability to survive inside macrophages. A minimal model is proposed to study the interaction of P. aeruginosa and the human host in terms of nested defence, in which the host and pathogen counter each other in a back-and-forth interaction. In particular, the pathogen attacks the host, macrophages of the host engulf the pathogen and reduce its access to glucose, the pathogen activates the glyoxylate shunt which is started by an enzyme isocitrate lyase (Icl), the host inhibits it by itaconic acid, and the pathogen metabolizes itaconic acid using the enzyme succinyl-CoA:itaconate CoA transferase (Ict). Therefore, the pathogen needs to allocate its limited protein resource between the enzymes Icl and Ict in order to maximize the time integral of a flux through the enzyme Icl. We use both random search and dynamic optimization and analyze three different scenarios of the interaction. We identify the enzyme Ict as a cost-effective means of counter-counter-counter defence and as a possible drug target.
Sexual reproduction and physiology of the soft coral Sclerophytum eilatenis along depth
Authors: liberman Ronen , Benayahu Yehuda , Tamir Shay 
Published: September 2024

Abstract

The ability of species to thrive across environmental gradients relies on their ability for sexual reproduction and physiological adaptations to varying conditions. Advances in diving technologies have enabled in-depth research into corals ecology and biology along depth gradients, from shallow-water habitats to mesophotic coral ecosystems (MCEs; 30-150 m). Findings from such studies suggest that MCEs may act as refugia for some species, providing shelter from threats such as global climate change and local stressors. However, effective refugia necessitate that individuals within a population can both reproduce sexually and adapt physiologically along their depth range. This study investigates the reproductive biology and physiological traits of the zooxanthellate octocoral Sclerophytum eilatenis along a depth gradient in the Gulf of Aqaba/Eilat. By examining sexual reproduction characteristics and the physiological parameters of both host and symbiont, this study provides a comprehensive view into this octocoral’s adaptive nature. The current study’s findings indicate that MCEs may serve as reproductive refugia for S. eilatenis, offering favorable conditions for sexual reproduction. However, significant variations in reproductive and physiological characteristics along depth underscore the necessity for careful evaluation of the potential for MCEs to assist in the recovery of shallow reef populations. This study highlights the importance of integrating reproduction and physiological data in order to advance our understanding of coral adaptation and resilience in dynamic marine environments.
Serum Extracellular Vesicles Reveal Metabolic Responses to Time-Restricted Feeding in High Fat Diet-Induced Obesity in Male Mice
Authors: Chen Xiaoli , Bushman Theresa , Lin Te-Yueh , Fu Qin , Zhang Sheng 
Published: September 2024

Abstract

Objective
Extracellular vesicle (EV) secretion and cargo composition are dysregulated in metabolic diseases. This study aimed to identify changes in the EV size profile and protein cargoes in diet-induced obesity following time-restricted feeding (TRF) and to establish the role of EVs in obesity-related metabolic responses.
Methods
Mice were fed a high-fat diet (HFD) for 18 weeks prior to being placed either ad libitum or a time-restricted feeding for an additional 10 weeks. Mice on a normal chow ad libitum served as the control. The TRF group had food available for 10 hours and fasted for 14 hours per day.
Results
The serum EV size profile and amount displayed sex- and age-dependent changes in HFD-induced obesity, with age reducing EV amounts. HFD decreased small EV populations and increased larger EV populations, while TRF reversed these changes. Quantitative proteomic analysis showed that the abundance and composition of EV proteins changed in response to both acute stimulation with lipopolysaccharides (LPS) and HFD. Gene ontology analysis identified specific sets of EV proteins and their involved biological processes, reflecting the effect of LPS and HFD, as well as the reversal effect of TRF on metabolic and inflammatory pathways. EV proteins altered by HFD and those reversed by TRF had low protein overlap but significant functional overlap in biological processes. TRF activated the PPAR signaling pathway and the AKT-mTOR signaling pathway. The most significant impacts of HFD and TRF were observed on lipoprotein and carbohydrate metabolism, complement system, and neutrophil degranulation. The reversal effect of TRF on the complement system was pathway-specific, significantly activating the lectin complement pathway and restoring neutrophil degranulation.
Conclusion
Our data indicate that EVs are involved in diet-induced metabolic and inflammatory responses. Different EV populations may carry distinct sets of proteins involved in specific biological processes, thereby regulating diverse metabolic pathways efficiently.
Association between stress hyperglycemia ratio and No-reflow phenomenon in AMI patients undergoing primary percutaneous coronary intervention
Authors: Wu Peng , Wang Mohan , Ma Juan , Zhu Baozhen , Jia Shaobin , Ma Xueping , Yan Ning 
Published: September 2024

Abstract

The relationship between the stress hyperglycemia ratio (SHR) and no-reflow phenomenon (NRP) in acute myocardial infarction (AMI) patients undergoing primary percutaneous coronary intervention (PPCI) remains unclear. This study aimed to investigate the association between baseline SHR and NRP in AMI patients undergoing PPCI and to further explore whether neutrophils play a mediating role. The study enrolled 2725 patients with AMI after PPCI from the General Hospital of Ningxia Medical University. Patients were divided into tertiles according to the NRP and SHR levels. The characteristics of baseline data of each group were recorded. A multivariate logistic regression model was developed to analyze the association between SHR and neutrophils with NRP. The linear association between baseline SHR and NRP was explored using smooth curve fitting. Correlation analysis was employed to evaluate the relationship between SHR, NRP, and neutrophils. Mediation analysis was conducted to determine whether the association between SHR and the NRP was mediated by neutrophils and to quantify the extent of this mediation. After controlling for confounding factors, the multivariate logistic regression model showed that SHR was an independent risk factor for the NRP (OR = 3.133, 95% CI: 1.700 - 5.548, P=0.0001), and neutrophils was also an independent risk factor for the NRP (OR = 1.113, 95% CI: 1.049 – 1.180, P=0.0003). Additionally, as the SHR and neutrophils quartiles increased, the incidence of NRP also gradually increased, with a significant P-trend (P -trend < 0.05). Smooth curve fitting and subgroup analysis were used to investigate the linear relationship between baseline SHR and NRP. The correlation relationship results showed that SHR was positively correlated with NRP (r=0.122, p <0.0001) and neutrophils (r=0.187, p <0.0001). Neutrophils was positively correlated with NRP (r=0.068, P=0.0004). The mediating effect analysis showed that SHR played a partial mediating role in NRP [indirect effect :0.0028(0.0006-0.0052), P=0.010], accounting for 9.03% of the total effect. Neutrophils plays a mediating role in the effects of SHR and NRP. The SHR was independently associated with no reflow phenomenon, and neutrophils play a mediating role. The SHR can be used to assess the risk of AMI patients undergoing PPCI.
Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis
Authors: Götz Friedrich , Li Ningna , Deshmukh Meghshree , Sahin Filiz , Hafza Nourhane , Ammanath Aparna , Ehnert Sabrina , Nussler Andreas K. , Weber Alexander , Jin Tao 
Published: September 2024

Abstract

Septic arthritis, primarily caused by Staphylococcus aureus, poses a significant risk of both mortality and morbidity due to its aggressive nature. The nuc1-encoded thermonuclease NucA of S. aureus degrades extracellular DNA/RNA, allowing the pathogen to escape neutrophil extracellular traps (NETs) and maintain the infection unabated. Here we show that in the mouse model for hematogenous septic arthritis the Δnuc1 mutant was much less pathogenic and the severity of clinical septic arthritis was markedly reduced, including decreased weight loss, lower kidney bacterial loads and much less IL-6 production. In vitro, S. aureus genomic DNA induced in macrophages a robust TNF-α response which was abrogated when the DNA was degraded by NucA. NucA induced higher IL-6 production in SAOS-2 and higher TNF-α and IL-10 production in neutrophils and shielded S. aureus from phagocyte engulfment and killing. NucA exacerbates septic arthritis possibly by increased internalization by host cells and killing of neutrophiles.
Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing
Authors: Li Yongzheng , Dong Lingling , Chen Yani , Cai Wenjin , Yang Guoli , Wang Ying 
Published: September 2024

Abstract

Background
A growing body of evidence supports the notion that mesenchymal stem cells (MSCs) are responsible for repairing traumatized tissues primarily through paracrine secretion and differentiation into specific cell types. However, the role of epithelial differentiation of MSCs in cutaneous wound healing is not well understood. In this study, we investigated the epithelial differentiation potential of gingival tissue-derived MSCs (GMSCs) in epithelial cell growth medium and probed the mechanisms underlying their differentiation into an epithelial-like cell phenotype.
Methods
GMSCs were examined by scanning electron microscopy for epithelial differentiation. Genes and proteins related to epithelial differentiation were quantified by quantitative real-time PCR and western blot, respectively. Subcellular localization of the KLF4, KRT19, and β-catenin proteins was analyzed by immunofluorescence. The mechanisms underlying epithelial differentiation in GMSCs were enriched by transcriptome sequencing. The wound healing rate and re-epithelialization were evaluated by a macroscopical view and hematoxylin eosin staining.
Results
GMSCs cultured in epithelial cell growth medium from day 3 to day 15 showed decreased expression of mesenchymal-epithelial transition and stemness-related proteins (N-cadherin, Vimentin, KLF4, and SOX2) and increased expression of epithelial-related proteins (KRT12, KRT15, KRT19, and E-cadherin), in addition to exhibiting epithelial-like morphology. Mechanistically, high-throughput sequencing results showed that the Wnt signaling pathway and TGF-beta signaling pathway were inhibited in epithelial differentiation of GMSCs (Epi-GMSCs). Furthermore, we demonstrated the ability of Epi-GMSCs to facilitate wound healing by enhancing re-epithelialization in a full-thickness skin defect model.
Conclusions
Collectively, this study uncovers that GMSCs have the ability to differentiate into epithelia and highlights a promising strategy for using Epi-GMSCs to improve cutaneous wound healing.
Optimizing Radiation Monitoring Networks to Improve Emergency Response Strategies during Nuclear Power Plant Accidents
Authors: Gellenoncourt Allan , Ayoub Ali , Wainwright Haruko M. 
Published: September 2024

Abstract

This paper presents a new strategy to optimize radiation monitoring networks for effectively predicting contaminated areas and radiation levels during nuclear power plant accidents in order to improve emergency response efforts. Our strategy addresses variable metrological fields by generating ensemble simulations of wind fields and radionuclide migration in the atmosphere using the WSPEEDI (Worldwide version of System for Prediction of Environmental Emergency Dose Information) simulator. GPCAM (Gaussian Process for Continuous-time Acquisition of Measurements) is then used to capture the heterogeneity of radiation levels by sparse monitoring points, and to optimize their locations. We consider three different scenarios: (a) a single static spatial distribution of the radiation levels, (b) the temporal evolution of the distribution within a single release scenario for mobile sensor deployment, and (c) ensemble optimization with variable metrological conditions for assessing risks and emergency responses at a particular site a priori. The results are compared with the homogeneously-distributed network. Our results show that GPCAM is able to identify effective monitoring locations for each of these scenarios, except that a prevailing wind direction is required for the ensemble case. In addition, we compare the effect of different acquisition functions, kernel functions, and hyperparameters in GPCAM on the sensor locations.
Identifying Plasmodium P36 and P52 antigens for co-administration with circumsporozoite protein to enhance vaccine efficacy
Authors: Murphy Sean , Yadav Naveen , Kalata Anya , Reynolds Rebekah , Raappana Andrew , Sather Noah 
Published: September 2024

Abstract

Vaccines targeting the complex pre-erythrocytic stage of Plasmodium parasites may benefit from inclusion of multiple antigens. However, discerning protective effects can be difficult because newer candidates may not be as protective as leading antigens like the circumsporozoite protein (CSP) in the conventional pre-clinical mouse model. We developed a modified mouse model challenge strategy that maximizes the contribution of T cells induced by novel candidate antigens at the sporozoite challenge time point and used this approach to test Plasmodium P36 and P52 vaccine candidates alone and in concert with non-protective doses of CSP. Co-administration of P36 and/or P52 with CSP achieved 80-100% sterile protection in mice, compared to only 7-30% protection for each individual antigen. P36 and P52 vaccination induced murine CD4+ and CD8+ T cell responses, but not antibody responses. This study adds P36 and P52 as promising vaccine antigens that may enhance protection achieved by CSP vaccination.
Analysis of Magnetic Field Effects on Snubber Resistance of Induction Melting Furnaces
Authors: Azizi Yousef 
Published: September 2024

Abstract

This study investigates the effects of magnetic fields on the snubber resistance in induction melting furnaces. Through a combination of laboratory experiments and numerical simulations using ANSYS Fluent, the study analyzes the impact of varying magnetic field intensities and Reynolds numbers on heat transfer. The experiments and simulations utilize different cross-sectional geometries for heat exchangers and incorporate nanofluids to enhance thermal performance. The findings reveal significant improvements in heat transfer efficiency due to the application of magnetic fields and the use of nanofluids.