bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Migraine Headaches With Suicidal Ideation Among Pregnant Women in Lima, Peru
Authors: Friedman Lauren E. , Gelaye Bizu , Rondon Marta B. , Sanchez Sixto E. , Peterlin B. Lee , Williams Michelle A. 
Published: March 2016

BackgroundSuicide is a leading cause of maternal death globally, and suicide prevalence rates have been shown to be increased in those with migraine. No previous study has examined the association between migraine and suicidal ideation during pregnancy.ObjectiveTo examine the association between migraine and suicidal ideation among a cohort of pregnant women.MethodsA cross‐sectional study was conducted among 3372 pregnant women attending prenatal care clinics in Lima, Peru. Suicidal ideation and depression were assessed using the Patient Health Questionnaire‐9 (PHQ‐9) scale during early pregnancy. Migraine classification (including migraine and probable migraine) was based on International Classification of Headache Disorders‐III beta criteria. Multivariable logistic regression analyses were performed to estimate odds ratios (OR) and 95% confidence intervals (95%CI).ResultsSuicidal ideation was more common among those with migraine (25.6%) as compared to those with probable migraine (22.1%, P < .001) or non‐migraineurs (12.3%, P < .001). After adjusting for confounders, including depression, those with migraine or probable migraine had a 78% increased odds of suicidal ideation (OR = 1.78; 95% CI: 1.46‐2.17), as compared with non‐migraineurs. Women with both migraine and depression had a 4.14‐fold increased odds of suicidal ideation (OR = 4.14; 95% CI: 3.17‐5.42) compared to those with neither condition.ConclusionMigraine is associated with increased odds of suicidal ideation in pregnant women even when controlling for depression. These findings support the consideration of screening women with comorbid migraine and depression for suicidal behavior during pregnancy.
HLA‐B allele dropout in PCR sequence‐specific oligonucleotide probe typing due to intronic polymorphism in the novel B*58:01:01:02 allele
Authors: He Y. , Wang W. , Han Z. , He J. , Chen N. , Dong L. , Tao S. , Zhang W. , He J. , Zhu F. , Lv H. 
Published: March 2016

SummaryCurrently, Luminex technology based on the PCR sequence‐specific oligonucleotide (SSO) probe method has been widely used for HLA genotyping in the immunogenetics laboratories. Here, we reported a case with HLA‐B allele dropout by Luminex technology. The initial HLA‐B result of the Luminex method with a commercial agent kit was inconclusive, and then, the result of PCR‐SBT technology indicated the dropout as a HLA‐B*58 allele. Subsequently, the full‐length sequence of HLA‐B allele was determined by TOPO‐TA cloning, and a novel allele B*58:01:01:02 was identified in the individual. Compared with HLA‐B*58:01:01:01, the novel allele showed some nucleotides difference at 509 C>T, 521 T>G and CCC insertion in position 503 of intron 2. According to the full‐length sequence, the new mutations of intron 2 were contributed to HLA‐B locus allele dropout in the sample. Our results indicated multiplatform should be used to improve the HLA typing accuracy when a conclusive HLA genotype cannot be determined.
Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions
Authors: Todd Tiffany W. , Petrucelli Leonard 
Published: March 2016

AbstractThe identification of a hexanucleotide repeat expansion in a non‐coding region of C9orf72 as a major cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) drastically changed the field of research on both of these conditions. Yet, despite the vast amount of work aimed at elucidating the molecular mechanisms underlying the role of this repeat in disease, the exact pathomechanisms are still unclear. A reduction in the expression of the C9orf72 gene is observed in patients, but a gain‐of‐function model is now preferred. The hexanucleotide repeat expansion forms RNA foci in the central nervous system (CNS) of repeat‐positive FTD and ALS patients, and these foci are believed to sequester RNA‐binding proteins (RBPs) and impair their function in RNA processing. At the same time, the repeat undergoes repeat‐associated non‐ATG translation to produce dipeptide repeat proteins that also form inclusions in the patient CNS. Studies from cells and flies suggest that these proteins may also be an important factor in the disease. Finally, the hexanucleotide repeat also induces the mislocalization and aggregation of TAR DNA‐binding protein 43 (TDP‐43) through an as yet unknown mechanism. This review covers the different potential pathogenic factors that have been put forth for C9orf72‐repeat‐associated FTD and ALS (C9‐FTD/ALS), while highlighting some remaining questions.
image
A repeat expansion in C9orf72 is a common cause of both frontal temporal dementia and amyotrophic lateral sclerosis. Although there is a decrease in C9orf72 expression in patients, this repeat is believed to induce disease primarily through an unknown gain‐of‐function mechanism involving the RNA, repeat‐associated non‐AUG translation, or both. This review summarizes and discusses current knowledge on C9orf72 repeat‐associated pathophysiology.This article is part of the Frontotemporal Dementia special issue.
Improving Practices of Risk Assessment and Intervention Planning for Persons with Intellectual Disabilities Who Sexually Offend
Authors: Keller Jason 
Published: March 2016

AbstractProactive assessment and intervention planning should be undertaken in cases of sexual behavior by persons with intellectual disability (ID) that is outside of acceptable norms. Although best practices in risk assessment for the general offender population are somewhat established, sexually inappropriate behavior among individuals with ID is distinct. Research in effective specialized risk assessment and intervention planning for this client group is an emerging area of focus. This article reviews contemporary academic research on this subject and highlights opportunities for improvement. First, research on risk factors for this client group was reviewed, observing the differences between empirically validated common factors and factors that are specific to the individual. Second, existing actuarial and structured clinical judgment approaches were evaluated. Third, the person‐centered planning approach to service planning for persons with ID was examined, highlighting how the principles of this approach may be used to enhance current practices in risk assessment and intervention planning. The author concludes that effective collaboration between support teams and clinical professionals, with focus maximized on individual risk factors and strengths, should lead to improved outcomes of risk assessment and intervention planning for persons with ID whose sexual behavior is inappropriate. A call to action is presented for the development of an enhanced, fourth‐generation, approach that embodies a collaborative framework.
Predictors of motivation to comply with social referents regarding one's romantic relationship
Authors: ETCHEVERRY PAUL E. , AGNEW CHRISTOPHER R. 
Published: March 2016

AbstractThis research examined predictors of motivation to comply with social referents regarding one's romantic relationship. Two variables are argued to predict motivation to comply with the opinions of social network members: (a) social consequences of compliance and (b) perceived relationship expertise. Three studies examined the association of these variables with motivation to comply. Study 1 used survey research to demonstrate that these variables predict motivation to comply. Studies 2 and 3 experimentally manipulated social consequences of compliance and perceived relationship expertise, respectively, providing evidence of a causal connection between these variables and motivation to comply. Across three studies, the results support the role of social consequences of compliance and perceived relationship expertise in understanding social influences on romantic decision making.
Arginase activity in Arabidopsis thaliana infected with Heterodera schachtii
Authors: Labudda M. , Różańska E. , Cieśla J. , Sobczak M. , Dzik J. M. 
Published: March 2016

The activity of arginase (ARGAH), which results in ornithine and urea production, is important for nitrogen metabolism in all organisms as well as for defence responses. The second‐stage juveniles of the cyst‐forming nematode Heterodera schachtii penetrate roots and induce the formation of a permanent feeding site. To determine whether infection with H. schachtii causes the induction of arginase, the expression was studied in Arabidopsis roots and shoots at the day of inoculation and at 3, 7 and 15 days post‐inoculation (dpi). Parasite infection caused a strong decrease of root arginase activity and ARGAH1 gene expression, which persisted over the entire examination period. In shoots, the mRNA expression of ARGAH2 increased at 3 and 7 dpi, but the enzymatic activity was significantly enhanced only at 3 dpi. Thus, while arginase down‐regulation occurs in roots, which is apparently due to the presence of nematode effectors, in shoots the activity is only transiently up‐regulated despite persistently high gene expression. As oxidative stress is possible during nematode infection, the activity and gene expression of glutathione reductase, a marker of the redox equilibrium, were estimated and found to be significantly enhanced at 7 dpi in shoots of infected plants. The level of proline, an amino acid known for its ability to scavenge free radicals, was increased 60‐fold. The results suggest that the disruption of redox homeostasis, as reflected by increased proline level and glutathione reductase expression and activity, accompanies changes in arginine metabolism in the shoots, indicating systemic changes induced by nematode infection.
Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body
Authors: Thompson Emma L. , Ray Clare J. , Holmes Andrew P. , Pye Richard L. , Wyatt Christopher N. , Coney Andrew M. , Kumar Prem 
Published: March 2016

Key points
Hypoglycaemia is counteracted by release of hormones and an increase in ventilation and CO2 sensitivity to restore blood glucose levels and prevent a fall in blood pH.
The full counter‐regulatory response and an appropriate increase in ventilation is dependent on carotid body stimulation.
We show that the hypoglycaemia‐induced increase in ventilation and CO2 sensitivity is abolished by preventing adrenaline release or blocking its receptors.
Physiological levels of adrenaline mimicked the effect of hypoglycaemia on ventilation and CO2 sensitivity.
These results suggest that adrenaline, rather than low glucose, is an adequate stimulus for the carotid body‐mediated changes in ventilation and CO2 sensitivity during hypoglycaemia to prevent a serious acidosis in poorly controlled diabetes.
AbstractHypoglycaemia in vivo induces a counter‐regulatory response that involves the release of hormones to restore blood glucose levels. Concomitantly, hypoglycaemia evokes a carotid body‐mediated hyperpnoea that maintains arterial CO2 levels and prevents respiratory acidosis in the face of increased metabolism. It is unclear whether the carotid body is directly stimulated by low glucose or by a counter‐regulatory hormone such as adrenaline. Minute ventilation was recorded during infusion of insulin‐induced hypoglycaemia (8–17 mIU kg−1 min−1) in Alfaxan‐anaesthetised male Wistar rats. Hypoglycaemia significantly augmented minute ventilation (123 ± 4 to 143 ± 7 ml min−1) and CO2 sensitivity (3.3 ± 0.3 to 4.4 ± 0.4 ml min−1 mmHg−1). These effects were abolished by either β‐adrenoreceptor blockade with propranolol or adrenalectomy. In this hypermetabolic, hypoglycaemic state, propranolol stimulated a rise in , suggestive of a ventilation–metabolism mismatch. Infusion of adrenaline (1 μg kg−1 min−1) increased minute ventilation (145 ± 4 to 173 ± 5 ml min−1) without altering or pH and enhanced ventilatory CO2 sensitivity (3.4 ± 0.4 to 5.1 ± 0.8 ml min−1 mmHg−1). These effects were attenuated by either resection of the carotid sinus nerve or propranolol. Physiological concentrations of adrenaline increased the CO2 sensitivity of freshly dissociated carotid body type I cells in vitro. These findings suggest that adrenaline release can account for the ventilatory hyperpnoea observed during hypoglycaemia by an augmented carotid body and whole body ventilatory CO2 sensitivity.
Intraspecific Competition Impacts Vibrio fischeri Strain Diversity during Initial Colonization of the Squid Light Organ
Authors: Sun Yan , LaSota Elijah D. , Cecere Andrew G. , LaPenna Kyle B. , Larios-Valencia Jessie , Wollenberg Michael S. , Miyashiro Tim 
Published: March 2016

ABSTRACT

Animal development and physiology depend on beneficial interactions with microbial symbionts. In many cases, the microbial symbionts are horizontally transmitted among hosts, thereby making the acquisition of these microbes from the environment an important event within the life history of each host. The light organ symbiosis established between the Hawaiian squid
Euprymna scolopes
and the bioluminescent bacterium
Vibrio fischeri
is a model system for examining how hosts acquire horizontally transmitted microbial symbionts. Recent studies have revealed that the light organ of wild-caught
E. scolopes
squid contains polyclonal populations of
V. fischeri
bacteria; however, the function and development of such strain diversity in the symbiosis are unknown. Here, we report our phenotypic and phylogenetic characterizations of FQ-A001, which is a
V. fischeri
strain isolated directly from the light organ of an
E. scolopes
individual. Relative to the type strain ES114, FQ-A001 exhibits similar growth in rich medium but displays increased bioluminescence and decreased motility in soft agar. FQ-A001 outcompetes ES114 in colonizing the crypt spaces of the light organs. Remarkably, we find that animals cocolonized with FQ-A001 and ES114 harbor singly colonized crypts, in contrast to the cocolonized crypts observed from competition experiments involving single genotypes. The results with our two-strain system suggest that strain diversity within the squid light organ is a consequence of diversity in the single-strain colonization of individual crypt spaces.

IMPORTANCE
The developmental programs and overall physiologies of most animals depend on diverse microbial symbionts that are acquired from the environment. However, the basic principles underlying how microbes colonize their hosts remain poorly understood. Here, we report our findings of bacterial strain competition within the coevolved animal-microbe symbiosis composed of the Hawaiian squid and bioluminescent bacterium
Vibrio fischeri
. Using fluorescent proteins to differentially label two distinct
V. fischeri
strains, we find that the strains are unable to coexist in the same niche within the host. Our results suggest that strain competition for distinct colonization sites dictates the strain diversity associated with the host. Our study provides a platform for studying how strain diversity develops within a host.
Meldonium use by athletes at the Baku 2015 European Games
Authors: Stuart Mark , Schneider Christian , Steinbach Klaus 
Published: March 2016

BackgroundThe aim of this report was to estimate the prevalence of meldonium use in athletes competing in the Baku 2015 European Games to contribute to the surveillance of substances on the 2015 World Anti-Doping Agency (WADA) Monitoring Program. Meldonium is reported to be used by athletes to potentially enhance personal performance and shorten the recovery period after physical activity.MethodsThree sources of data were reviewed to determine the prevalence of meldonium use during the Games including: (1) athlete self-reported declarations of drug and supplement use; (2) declarations from National Olympic Committee medical teams of the list of medicines that they imported into Azerbaijan as part of their stock of drugs for administration; (3) results from the antidoping laboratories reporting the detection of meldonium.ResultsMeldonium was declared as imported into Azerbaijan by 2 of 50 National Olympic Committee medical teams at the Games, but athletes from 6 countries declared the use of meldonium. Only 23 of the 662 (3.5%) athletes tested from 8 to 28 June 2015 declared the personal use of meldonium, which included 13 competition winners. However, 66 of the total 762 (8.7%) athlete urine samples analysed during the Games and during precompetition tested positive for meldonium. Meldonium use was detected in athletes competing in 15 of the 21 sports during the Games.ConclusionsThis study highlights the widespread and inappropriate use and prescribing of this prescription drug in a generally healthy athlete population. Subsequent to these findings, WADA has included meldonium as a prohibited substance on the 2016 List of Prohibited Substances.
Injury recurrence is lower at the highest professional football level than at national and amateur levels: does sports medicine and sports physiotherapy deliver?
Authors: Hägglund Martin , Waldén Markus , Ekstrand Jan 
Published: March 2016

BackgroundPrevious injury is a well-documented risk factor for football injury. The time trends and patterns of recurrent injuries at different playing levels are not clear.AimTo compare recurrent injury proportions, incidences and patterns between different football playing levels, and to study time trends in recurrent injury incidence.MethodsTime-loss injuries were collected from injury surveillance of 43 top-level European professional teams (240 team-seasons), 19 Swedish premier division teams (82 team-seasons) and 10 Swedish amateur teams (10 team-seasons). Recurrent injury was defined as an injury of the same type and at the same site as an index injury within the preceding year, with injury <2 months defined as an early recurrence, and >2 months as a delayed recurrence. Seasonal trend for recurrent injury incidence, expressed as the average annual percentage of change, was analysed using linear regression.Results13 050 injuries were included, 2449 (18.8%) being recurrent injuries, with 1944 early (14.9%) and 505 delayed recurrences (3.9%). Recurrence proportions were highest in the second half of the competitive season for all cohorts. Recurrence proportions differed between playing levels, with 35.1% in the amateur cohort, 25.0% in the Swedish elite cohort and 16.6% in the European cohort (χ2overall effect, p<0.001). A decreasing trend was observed in recurrent injury incidence in the European cohort, a −2.9% average annual change over the 14-year study period (95% CI −5.4% to −0.4%, p=0.026). Similarly, a decreasing tendency was also seen in the Swedish premier division.ConclusionsRecurrence proportions showed an inverse relationship with playing level, and recurrent injury incidence has decreased over the past decade.
Can the provision of a home help service for the elderly population reduce the incidence of fall-related injuries? A quasi-experimental study of the community-level effects on hospital admissions in Swedish municipalities
Authors: Bonander Carl , Gustavsson Johanna , Nilson Finn 
Published: March 2016

BackgroundFall-related injuries are a global public health problem, especially in elderly populations. The effect of an intervention aimed at reducing the risk of falls in the homes of community-dwelling elderly persons was evaluated. The intervention mainly involves the performance of complicated tasks and hazards assessment by a trained assessor, and has been adopted gradually over the last decade by 191 of 290 Swedish municipalities.MethodsA quasi-experimental design was used where intention-to-treat effect estimates were derived using panel regression analysis and a regression discontinuity (RD) design. The outcome measure was the incidence of fall-related hospitalisations in the treatment population, the age of which varied by municipality (≥65 years, ≥67 years, ≥70 years or ≥75 years).ResultsWe found no statistically significant reductions in injury incidence in the panel regression (IRR 1.01 (95% CI 0.98 to 1.05)) or RD (IRR 1.00 (95% CI 0.97 to 1.03)) analyses. The results are robust to several different model specifications, including segmented panel regression analysis with linear trend change and community fixed effects parameters.ConclusionsIt is unclear whether the absence of an effect is due to a low efficacy of the services provided, or a result of low adherence. Additional studies of the effects on other quality-of-life measures are recommended before conclusions are drawn regarding the cost-effectiveness of the provision of home help service programmes.
Semantic Similarity/Relatedness for Cross Language Plagiarism Detection
Authors: Ezzikouri Hanane , Erritali Mohammed , Oukessou Mohamed 
Published: March 2016

<p>Generally utterances in natural language are highly ambiguous, and a unique interpretation can usually be determined only by taking into account the context in the utterance occurred. Automatically determining the correct sense of a polysemous word is a complicated problem especially in multilingual corpuses. This paper presents an application programming interface for several Semantic Relatedness/Similarity metrics measuring semantic similarity/distance between multilingual words and concepts, in order to use it after for sentences and paragraphs in Cross Language Plagiarism Detection (CLPD); using WordNet for the English-French and English-Arabic multilingual plagiarism cases.</p>
Evaluating the level of sustainability of privately managed forest in Bogor, Indonesia
Authors: SUKWIKA TATAN , DARUSMAN DUDUNG , KUSMANA CECEP , NURROCHMAT DODIK RIDHO 
Published: March 2016

Sukwika T, Darusman D, Kusmana C, Nurrochmad DR. 2016. Evaluating the level of sustainability of privately managedÂ forest in Bogor, Indonesia. Biodiversitas 17: 241-248. This study discusses the sustainability of small scale private forest in Bogor,Â Indonesia. It aims to determine the dimensions of sustainable private-forest and analyzing the sustainability index of privately managedÂ forest. This study uses multidimensional scaling (MDS)Â o analyze the dimensions of sustainability, ranked from 0 (the lowest) to 10 (the highest), along with the support of Rap-Pforest, in order to assess the level of similarity and dissimilarity for each dimension. Using this scale from the sustainability index, this study estimates the level of sustainability of each dimension. After measuring each attributeâ€™s level of ordination RMS change on the X axis, we estimate the errorâ€™s effect using Monte Carlo analysis. This study shows that the ecology as well as legal and institutional dimensions are moderately sustainable, with a sustainability index of 53.66% andÂ 52.48%. However, the dimensions of economy, socio-culture, as well as accessibility and technology are less sustainable, with an indexÂ measurement of 41.62%, 47.02% and 47.56%, respectively. Based on those five sustainability dimensions, this study concludes that inÂ average the level of sustainability of private-forest management in the Bogor is not sustainable (48.47%). We recommend that to improve the sustainability of small scale private forest management in Bogor, multiple stakeholders should be involved to development the most appropriate policy options.