bluuebunny/crossref_metadata_2025_split huggingface dataset:
What If “Just Right” Is Just Wrong? The Unintended Consequences of Leveling Readers
Authors: Hoffman James V. 
Published: June 2017

AbstractThe author questions the “just right” leveling of student texts as having put limitations on students and teachers in promoting literacy. The historical background for the leveling of text and readers is described. The author identifies a number of unintended consequences associated with the use of leveling and guided reading. Alternatives to leveling and guided reading are presented, with a particular focus on work in informational texts in inquiry.
Assessment of the Validity and Reproducibility of a Novel Standardized Test Meal for the Study of Postprandial Triacylglycerol Concentrations
Authors: Tentolouris Nikolaos , Kanellos Panagiotis T. , Siami Evangelia , Athanasopoulou Elpida , Chaviaras Nikolaos , Kolovou Genovefa , Sfikakis Petros P. , Katsilambros Nikolaos 
Published: June 2017

AbstractLipotest® is a standardized fat‐rich meal designed for use as a test meal during a fat tolerance test (FTT) for the study of postprandial triacylglycerol (TAG) concentrations. Herein we examined the precision and reproducibility of examination using Lipotest® on postprandial TAG levels. A total of 26 healthy consenting subjects were examined twice after 8–10 h fasting with an interval of approximately 1 week apart. Blood samples were collected at baseline and 1, 2, 3, and 4 h after consumption of the test meal for measurement of plasma total TAG levels. We examined agreement, precision, and accuracy between the two visits using the Altman plots and correlation coefficient. Reproducibility was tested using the coefficient of variation (CV) and intraclass correlation coefficient (ICC). Moreover, the area under the curve (AUC) as a summary measure of the overall postprandial TAG levels was calculated. The agreement, precision (r ≥ 0.74, p < 0.001), and accuracy (≥0.99) between the measurements in plasma TAG during Lipotest® testing in the two visits were high. In terms of reproducibility, the values of CV were 15.59–23.83% while those of ICC were ≥0.75. The values of the AUCs in the visits were not different (p = 0.87). A single measurement of plasma TAG levels at 4 h after Lipotest® consumption depicted peak postprandial TAG concentration. A FTT using Lipotest® as a standardized meal has good precision and reproducibility for the study of postprandial TAG levels in healthy individuals. A single determination of plasma TAG concentration at 4 h after Lipotest® consumption captures peak postprandial TAG response.
Revealing the potency of Annona muricata leaves extract as FOXO1 inhibitor for diabetes mellitus treatment through computational study
Authors: Damayanti Dini Sri , Utomo Didik Huswo , Kusuma Chandra 
Published: June 2017

AbstractFOXO1 protein inactivation in the nucleus is one of targets for the treatment of diabetes mellitus. Annona muricata leaves contain flavonoid and phenolic compound alkaloids that were known to be able to increase pancreatic β cell proliferation in animal experiment. This research aimed to predict the active compound ability of the Annona muricata leaves to bind and inhibit FOXO1 protein through in silico study. Analysis of molecular docking was performed by using Autodock Vina PyRx. this research proved that anonaine, rutin, muricatocin a, isolaureline, xylopine, and kaempferol 3-O-rutinoside had an equal or smaller free binding energy compared to the control compound. Rutin and Muricatocin A had the same binding ability toward 66% amino acid residues, compared to control compound with hydrogen bond type, while xylopine, anonaine, isolaureline, kaempferol 3-O-rutinoside had a similar binding ability towards 33% amino acid residues compared to control compound with hydrogen bond type.
Optimal dividend strategies for two collaborating insurance companies
Authors: Albrecher Hansjörg , Azcue Pablo , Muler Nora 
Published: June 2017

Abstract
We consider a two-dimensional optimal dividend problem in the context of two insurance companies with compound Poisson surplus processes, who collaborate by paying each other's deficit when possible. We study the stochastic control problem of maximizing the weighted sum of expected discounted dividend payments (among all admissible dividend strategies) until ruin of both companies, by extending results of univariate optimal control theory. In the case that the dividends paid by the two companies are equally weighted, the value function of this problem compares favorably with the one of merging the two companies completely. We identify the optimal value function as the smallest viscosity supersolution of the respective Hamilton–Jacobi–Bellman equation and provide an iterative approach to approximate it numerically. Curve strategies are identified as the natural analogue of barrier strategies in this two-dimensional context. A numerical example is given for which such a curve strategy is indeed optimal among all admissible dividend strategies, and for which this collaboration mechanism also outperforms the suitably weighted optimal dividend strategies of the two stand-alone companies.
Limit theorems associated with the Pitman–Yor process
Authors: Feng Shui , Gao Fuqing , Zhou Youzhou 
Published: June 2017

AbstractThe Pitman–Yor process is a random discrete measure. The random weights or masses follow the two-parameter Poisson–Dirichlet distribution with parameters 0 < α < 1, θ > -α. The parameters α and θ correspond to the stable and gamma components, respectively. The distribution of atoms is given by a probability η. In this paper we consider the limit theorems for the Pitman–Yor process and the two-parameter Poisson–Dirichlet distribution. These include the law of large numbers, fluctuations, and moderate or large deviation principles. The limiting procedures involve either α tending to 0 or 1. They arise naturally in genetics and physics such as the asymptotic coalescence time for explosive branching process and the approximation to the generalized random energy model for disordered systems.
Joint degree distributions of preferential attachment random graphs
Authors: Peköz Erol , Röllin Adrian , Ross Nathan 
Published: June 2017

AbstractWe study the joint degree counts in linear preferential attachment random graphs and find a simple representation for the limit distribution in infinite sequence space. We show weak convergence with respect to thep-norm topology for appropriatepand also provide optimal rates of convergence of the finite-dimensional distributions. The results hold for models with any general initial seed graph and any fixed number of initial outgoing edges per vertex; we generate nontree graphs using both a lumping and a sequential rule. Convergence of the order statistics and optimal rates of convergence to the maximum of the degrees is also established.
Rewritable ghost floating gates by tunnelling triboelectrification for two-dimensional electronics
Authors: Kim Seongsu , Kim Tae Yun , Lee Kang Hyuck , Kim Tae-Ho , Cimini Francesco Arturo , Kim Sung Kyun , Hinchet Ronan , Kim Sang-Woo , Falconi Christian 
Published: June 2017

AbstractGates can electrostatically control charges inside two-dimensional materials. However, integrating independent gates typically requires depositing and patterning suitable insulators and conductors. Moreover, after manufacturing, gates are unchangeable. Here we introduce tunnelling triboelectrification for localizing electric charges in very close proximity of two-dimensional materials. As representative materials, we use chemical vapour deposition graphene deposited on a SiO2/Si substrate. The triboelectric charges, generated by friction with a Pt-coated atomic force microscope tip and injected through defects, are trapped at the air–SiO2 interface underneath graphene and act as ghost floating gates. Tunnelling triboelectrification uniquely permits to create, modify and destroy p and n regions at will with the spatial resolution of atomic force microscopes. As a proof of concept, we draw rewritable p/n+ and p/p+ junctions with resolutions as small as 200 nm. Our results open the way to time-variant two-dimensional electronics where conductors, p and n regions can be defined on demand.
Structural and regulatory diversity shape HLA-C protein expression levels
Authors: Kaur Gurman , Gras Stephanie , Mobbs Jesse I. , Vivian Julian P. , Cortes Adrian , Barber Thomas , Kuttikkatte Subita Balaram , Jensen Lise Torp , Attfield Kathrine E. , Dendrou Calliope A. , Carrington Mary , McVean Gil , Purcell Anthony W. , Rossjohn Jamie , Fugger Lars 
Published: June 2017

AbstractExpression of HLA-C varies widely across individuals in an allele-specific manner. This variation in expression can influence efficacy of the immune response, as shown for infectious and autoimmune diseases. MicroRNA binding partially influences differential HLA-C expression, but the additional contributing factors have remained undetermined. Here we use functional and structural analyses to demonstrate that HLA-C expression is modulated not just at the RNA level, but also at the protein level. Specifically, we show that variation in exons 2 and 3, which encode the α1/α2 domains, drives differential expression of HLA-C allomorphs at the cell surface by influencing the structure of the peptide-binding cleft and the diversity of peptides bound by the HLA-C molecules. Together with a phylogenetic analysis, these results highlight the diversity and long-term balancing selection of regulatory factors that modulate HLA-C expression.
Insulated transcriptional elements enable precise design of genetic circuits
Authors: Zong Yeqing , Zhang Haoqian M. , Lyu Cheng , Ji Xiangyu , Hou Junran , Guo Xian , Ouyang Qi , Lou Chunbo 
Published: June 2017

AbstractRational engineering of biological systems is often complicated by the complex but unwanted interactions between cellular components at multiple levels. Here we address this issue at the level of prokaryotic transcription by insulating minimal promoters and operators to prevent their interaction and enable the biophysical modeling of synthetic transcription without free parameters. This approach allows genetic circuit design with extraordinary precision and diversity, and consequently simplifies the design-build-test-learn cycle of circuit engineering to a mix-and-match workflow. As a demonstration, combinatorial promoters encoding NOT-gate functions were designed from scratch with mean errors of <1.5-fold and a success rate of >96% using our insulated transcription elements. Furthermore, four-node transcriptional networks with incoherent feed-forward loops that execute stripe-forming functions were obtained without any trial-and-error work. This insulation-based engineering strategy improves the resolution of genetic circuit technology and provides a simple approach for designing genetic circuits for systems and synthetic biology.
The beetle elytron plate: a lightweight, high-strength and buffering functional-structural bionic material
Authors: Zhang Xiaoming , Xie Juan , Chen Jinxiang , Okabe Yoji , Pan Longcheng , Xu Mengye 
Published: June 2017

AbstractTo investigate the characteristics of compression, buffering and energy dissipation in beetle elytron plates (BEPs), compression experiments were performed on BEPs and honeycomb plates (HPs) with the same wall thickness in different core structures and using different molding methods. The results are as follows: 1) The compressive strength and energy dissipation capacity in the BEP are 2.44 and 5.0 times those in the HP, respectively, when the plates are prepared using the full integrated method (FIM). 2) The buckling stress is directly proportional to the square of the wall thickness (t). Thus, for core structures with equal wall thicknesses, although the core volume of the BEP is 42 percent greater than that of the HP, the mechanical properties of the BEP are several times higher than those of the HP. 3) It is also proven that even when the single integrated method (SIM) is used to prepare BEPs, the properties discussed above remain superior to those of HPs by a factor of several; this finding lays the foundation for accelerating the commercialization of BEPs based on modern manufacturing processes.
Pyrocurrent anomalies and intrinsic magnetodielectric behavior near room temperature in Li2Ni2Mo3O12, a compound with distorted honeycomb and spin-chains
Authors: Upadhyay Sanjay Kumar , Iyer Kartik K. , Gohil Smita , Ghosh Shankar , Paulose P. L. , Sampathkumaran E. V. 
Published: June 2017

AbstractKeeping current interests to identify materials with intrinsic magnetodielectric behaviour near room temperature and with novel pyroelectric current anomalies, we report temperature and magnetic-field dependent behavior of complex dielectric permittivity and pyroelectric current for an oxide, Li2Ni2Mo3O12, containing magnetic ions with (distorted) honey-comb and chain arrangement and ordering magnetically below 8 K. The dielectric data reveal the existence of relaxor ferroelectricity behaviour in the range 160–240 K and there are corresponding Raman mode anomalies as well in this temperature range. Pyrocurrent behavior is also consistent with this interpretation, with the pyrocurrent peak-temperature interestingly correlating with the poling temperature. 7Li NMR offer an evidence for crystallographic disorder intrinsic to this compound and we therefore conclude that such a disorder is apparently responsible for the randomness of local electric field leading to relaxor ferroelectric property. Another observation of emphasis is that there is a notable decrease in the dielectric constant with the application of magnetic field to the tune of about −2.4% at 300 K, with the magnitude varying marginally with temperature. Small loss factor values validate the intrinsic behaviour of the magnetodielectric effect at room temperature.
Novel carbon quantum dots from egg yolk oil and their haemostatic effects
Authors: Zhao Yan , Zhang Yue , Liu Xiaoman , Kong Hui , Wang Yongzhi , Qin Gaofeng , Cao Peng , Song Xingxing , Yan Xin , Wang Qingguo , Qu Huihua 
Published: June 2017

AbstractIn this study, the properties of egg yolk oil (EYO) were investigated. Water extraction, dialysis, and ultrafiltration were used to extract and purify EYO, and microscopy, spectrophotometry, and chromatography were used to identify carbon dots (CDs) present in EYO (EYO CDs). Morphology analyses demonstrated that CDs were almost spherical, with an average size of <10 nm, a lattice spacing of 0.267 nm, and a composition of mainly C, O, and Fe. The solution showed bright blue fluorescence at 365 nm. Tail haemorrhaging and liver haemorrhaging experiments showed that CD-treated mice had significantly shorter bleeding times than did control mice. Coagulation assays suggested that EYO CDs stimulate the intrinsic blood coagulation system and activate the fibrinogen system. Thus, EYO CDs possess the ability to activate haemostasis, which may lead to further investigations of this ingredient of traditional Chinese medicine.
Anterior Cervical Spondylosis Surgical Interventions are Associated with Improved Lordosis and Neurological Outcomes at Latest Follow up: A Meta-analysis
Authors: Meng Zengdong , Yu Jing , Luo Chong , Liu Xia , Jiang Wei , Yu Lehua , Huang Rongzhong 
Published: June 2017

AbstractAim of this study was to evaluate the effect of cervical spondylosis surgery on cervical lordosis and to identify factors affecting the change by latest follow-up. Literature search was carried out in electronic databases and study selection followed a priori eligibility criteria. Random effects meta-analyses were performed to estimate effect size/s of change in lordosis after surgery (at latest follow-up) and metaregression analyses were performed to identify factors affecting this change. Nineteen studies (1845 patients; age 55.18 [95% CI: 54.78, 55.57] years; 60.99 [60.63, 61.36] % males; follow-up 25.59 [25.20, 25.99] months) were included. Whereas, corpectomy (4.06 [2.65, 5.46] degree; p < 0.00001) and discectomy (4.59 [2.07, 7.11] degree; p < 0.00001) were associated with increase, laminectomy (−1.87 [−8.40, 4.66] degree; p = 0.57) and laminoplasty (0.25 [−1.07, 1.56] degree; p = 0.711) were not associated with significant change in lordosis at latest follow-up. Change in Japanese Orthopedic Association (JOA)/modified JOA (mJOA) score at latest follow-up was also significantly (p = 0.0005) higher in anterior than in posterior surgery group. Change in lordosis at latest follow-up had significant positive relationship with follow-up duration but had significant inverse associations with age, male gender, and preoperative JOA/mJOA score, independently. In posterior surgery subjects, after adjusting for age and gender, preoperative JOA/mJOA score was significantly inversely related to change in lordosis.
Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time
Authors: Revêchon Gwladys , Viceconte Nikenza , McKenna Tomás , Sola Carvajal Agustín , Vrtačnik Peter , Stenvinkel Peter , Lundgren Torbjörn , Hultenby Kjell , Franco Irene , Eriksson Maria 
Published: June 2017

AbstractAccumulation of progerin is believed to underlie the pathophysiology of Hutchinson-Gilford progeria syndrome, a disease characterized by clinical features suggestive of premature aging, including loss of subcutaneous white adipose tissue (sWAT). Although progerin has been found in cells and tissues from apparently healthy individuals, its significance has been debated given its low expression levels and rare occurrence. Here we demonstrate that sustained progerin expression in a small fraction of preadipocytes and adipocytes of mouse sWAT (between 4.4% and 6.7% of the sWAT cells) results in significant tissue pathology over time, including fibrosis and lipoatrophy. Analysis of sWAT from mice of various ages showed senescence, persistent DNA damage and cell death that preceded macrophage infiltration, and systemic inflammation. Our findings suggest that continuous progerin expression in a small cell fraction of a tissue contributes to aging-associated diseases, the adipose tissue being particularly sensitive.
Super-hydrophobic multilayer coatings with layer number tuned swapping in surface wettability and redox catalytic anti-corrosion application
Authors: Syed Junaid Ali , Tang Shaochun , Meng Xiangkang 
Published: June 2017

AbstractThe wetting characteristic of a metal surface can be controlled by employing different coating materials and external stimuli, however, layer number (n) modulated surface swapping between hydrophobicity and hydrophilicity in a multilayer structure to achieve prolonged anti-corrosion ability was not taken into consideration. In this study, we proposed a layer-by-layer (LbL) spin assembled polyaniline-silica composite/tetramethylsilane functionalized silica nanoparticles (PSC/TMS-SiO2) coating with the combined effect of super-hydrophobicity and enhanced anti-corrosion ability. Interestingly, the hierarchical integration of two coating materials with inherently different surface roughness and energy in a multilayer structure allows the wetting feature to swap from hydrophobic to hydrophilic state by modulating n with decreasing hydrophilicity. The samples with odd n (TMS-SiO2 surface) are hydrophobic while the samples with even n (PSC surface) exhibits the hydrophilic character. The TMS-SiO2 content was optimized to achieve super-hydrophobic coating with significantly high water contact angle (CA) 153° ± 2° and small sliding angle (SA) 6° ± 2°. Beside its self-cleaning behavior, the electro-active PSC/TMS-SiO2 coating also exhibits remarkably enhanced corrosion resistance against aggressive media. The corrosion resistance of the coating was remained stable even after 240 h of exposure, this enhancement is attributed to super-hydrophobicity and anodic shift in corrosion potential.
The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
Authors: Yan Dayun , Cui Haitao , Zhu Wei , Nourmohammadi Niki , Milberg Julian , Zhang Lijie G. , Sherman Jonathan H. , Keidar Michael 
Published: June 2017

AbstractCold atmospheric plasma (CAP), a novel promising anti-cancer modality, has shown its selective anti-cancer capacity on dozens of cancer cell lines in vitro and on subcutaneous xenograft tumors in mice. Over the past five years, the CAP-stimulated solutions (PSS) have also shown their selective anti-cancer effect over different cancers in vitro and in vivo. The solutions used to make PSS include several bio-adaptable solutions, mainly cell culture medium and simple buffered solutions. Both the CAP-stimulated medium (PSM) and the CAP-stimulated buffered solution (PSB) are able to significantly kill cancer cells in vitro. In this study, we systematically compared the anti-cancer effect of PSM and PSB over pancreatic adenocarcinoma cells and glioblastoma cells. We demonstrated that pancreatic cancer cells and glioblastoma cells were specifically vulnerable to PSM and PSB, respectively. The specific response such as the rise of intracellular reactive oxygen species of two cancer cell lines to the H2O2-containing environments might result in the specific vulnerabilities to PSM and PSB. In addition, we demonstrated a basic guideline that the toxicity of PSS on cancer cells could be significantly modulated through controlling the dilutability of solution.
Circulating Biomarkers to Identify Responders in Cardiac Cell therapy
Authors: Jokerst Jesse V. , Cauwenberghs Nicholas , Kuznetsova Tatiana , Haddad Francois , Sweeney Timothy , Hou Jiayi , Rosenberg-Hasson Yael , Zhao Eric , Schutt Robert , Bolli Roberto , Traverse Jay H. , Pepine Carl J. , Henry Timothy D. , Schulman Ivonne H. , Moyé Lem , Taylor Doris A. , Yang Phillip C. 
Published: June 2017

AbstractBone marrow mononuclear cell (BM-MNC) therapy in ST-elevation acute myocardial infarction (STEMI) has no biological inclusion criteria. Here, we analyzed 63 biomarkers and cytokines in baseline plasma samples from 77 STEMI patients treated with BM-MNCs in the TIME and Late-TIME trials as well as 61 STEMI patients treated with placebo. Response to cell therapy was defined by changes in left ventricular ejection fraction, systolic/diastolic volumes, and wall motion indexes. We investigated the clinical value of circulating proteins in outcome prediction using significance testing, partial least squares discriminant analysis, and receiver operating characteristic (ROC) analysis. Responders had higher biomarker levels (76–94% elevated) than non-responders. Several biomarkers had values that differed significantly (P < 0.05) between responders and non-responders including stem cell factor, platelet-derived growth factor, and interleukin-15. We then used these lead candidates for ROC analysis and found multiple biomarkers with values areas under the curve >0.70 including interleukin 15. These biomarkers were not involved in the placebo-treated subjects suggesting that they may have predictive power. We conclude that plasma profiling after STEMI may help identify patients with a greater likelihood of response to cell-based treatment. Prospective trials are needed to assess the predictive value of the circulating biomarkers.