bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamification for health promotion: systematic review of behaviour change techniques in smartphone apps
Authors: Edwards E A , Lumsden J , Rivas C , Steed L , Edwards L A , Thiyagarajan A , Sohanpal R , Caton H , Griffiths C J , Munafò M R , Taylor S , Walton R T 
Published: October 2016

ObjectiveSmartphone games that aim to alter health behaviours are common, but there is uncertainty about how to achieve this. We systematically reviewed health apps containing gaming elements analysing their embedded behaviour change techniques.MethodsTwo trained researchers independently coded apps for behaviour change techniques using a standard taxonomy. We explored associations with user ratings and price.Data sourcesWe screened the National Health Service (NHS) Health Apps Library and all top-rated medical, health and wellness and health and fitness apps (defined by Apple and Google Play stores based on revenue and downloads). We included free and paid English language apps using ‘gamification’ (rewards, prizes, avatars, badges, leaderboards, competitions, levelling-up or health-related challenges). We excluded apps targeting health professionals.Results64 of 1680 (4%) health apps included gamification and met inclusion criteria; only 3 of these were in the NHS Library. Behaviour change categories used were: feedback and monitoring (n=60, 94% of apps), reward and threat (n=52, 81%), and goals and planning (n=52, 81%). Individual techniques were: self-monitoring of behaviour (n=55, 86%), non-specific reward (n=49, 82%), social support unspecified (n=48, 75%), non-specific incentive (n=49, 82%) and focus on past success (n=47, 73%). Median number of techniques per app was 14 (range: 5–22). Common combinations were: goal setting, self-monitoring, non-specific reward and non-specific incentive (n=35, 55%); goal setting, self-monitoring and focus on past success (n=33, 52%). There was no correlation between number of techniques and user ratings (p=0.07; rs=0.23) or price (p=0.45; rs=0.10).ConclusionsFew health apps currently employ gamification and there is a wide variation in the use of behaviour change techniques, which may limit potential to improve health outcomes. We found no correlation between user rating (a possible proxy for health benefits) and game content or price. Further research is required to evaluate effective behaviour change techniques and to assess clinical outcomes.Trial registration numberCRD42015029841.
Cohort feasibility study of an intermittent pneumatic compression device within a below-knee cast for the prevention of venous thromboembolism
Authors: Braithwaite Irene , De Ruyter Bernadette , Semprini Alex , Ebmeier Stefan , Kiddle Grant , Willis Nigel , Carter John , Weatherall Mark , Beasley Richard 
Published: October 2016

ObjectivesTo determine the likely enrolment rate of eligible participants into a randomised controlled trial (RCT) in which a within-cast intermittent pneumatic compression device using Jet Impulse Technology (IPC/JIT) is 1 of 3 possible interventions in a RCT for the prevention of venous thromboembolism (VTE) in the clinical setting of isolated lower limb cast immobilisation.DesignA prospective, open-label feasibility study of the IPC/JIT device placed within a lower limb cast.SettingWellington Regional Hospital Fracture Clinic.ParticipantsIndividuals aged 18–70 who presented with a lower limb injury requiring a minimum of 4 weeks below-knee cast immobilisation.InterventionPlacement of an IPC/JIT device within lower limb cast.Outcome measuresThe main outcome measure was the proportion of eligible participants who participated in the feasibility study. Secondary outcome measures included adherence to device usage throughout the study, ease of application of the device and adverse events potentially associated with its use.ResultsThe proportion of potentially eligible participants for the IPC/JIT device was only 7/142 (5%), 95% CI 2 to 9.9. Devices were used for a mean (range) of 4.1 (1.9 to 10.2) hours per day and none of 7 participants had adequate adherence to the device. 3 of the 7 participants suffered an adverse event, including 1 deep vein thrombosis, 2 dorsal foot ulcer and 1 skin maceration.ConclusionsA within-cast IPC/JIT device is unlikely to be a feasible randomisation arm for a RCT assessing possible interventions for the reduction of VTE risk in the clinical setting of lower limb injury requiring below knee cast immobilisation for a minimum of 4 weeks.Trial registration numberANZCTR12615000192583.
Forty years of economic growth and plummeting mortality: the mortality experience of the poorly educated in South Korea
Authors: Bahk Jinwook , Lynch John W , Khang Young-Ho 
Published: October 2016

BackgroundSouth Korea has experienced rapid economic development and a substantial increase in life expectancy in an extremely short period. Whether this rapid development has been able to adequately address inequalities in health in South Korea may have important policy implications. This paper explores long-term trends in inequalities in mortality related to education in South Korea between 1970 and 2010.MethodsWe used secondary data on population size and deaths in 1970 and 1980 from a previously published study, and census and death certificate data from Statistics Korea from 1990, 1995, 2000, 2005 and 2010. Trends in age-standardised mortality rates for men and women aged 25–64 according to education, as well as the rate ratio (RR), rate difference (RD), relative index of inequality (RII) and slope index of inequality (SII), were examined over the period 1970–2010.ResultsDespite overall mortality declines of 70–80% in the past 4 decades, educational inequalities have increased or been stagnant. There was minimal decline in mortality since 1970 in South Koreans with only a primary or lower level of education. The RR and RD between tertiary education and primary or lower education increased over the study period, while the RII and the SII in both genders remained stable.ConclusionsThe South Korean experience over the past 40 years suggests that plummeting mortality rates and huge advances in education at the population level do not translate into reduced educational inequalities in mortality.
Dual protection to address the global syndemic of HIV and unintended pregnancy in Brazil
Authors: Tsuyuki Kiyomi , Gipson Jessica D , Urada Lianne A , Barbosa Regina Maria , Morisky Donald E 
Published: October 2016

BackgroundSyndemic HIV and unintended pregnancy is prevalent in Brazil, where 79% of female HIV cases occur in women of reproductive age and 55% of all pregnancies are unintended. Although increasing condom use to prevent HIV may decrease non-barrier contraception and increase unintended pregnancy, few studies focus on dual protection or dual methods (condoms with another modern contraceptive).AimTo describe the correlates of dual method use and consistent condom use in women of reproductive age in Brazil.MethodData are from the 2006 Pesquisa Nacional de Demografia e Saúde da Mulher e da Criança, a decennial nationally representative household survey of women of reproductive age in Brazil. Multivariate logistic regression models identify the socio-demographic, sexual debut, fertility and relationship factors associated with dual method use and consistent condom use.ResultsTwo-thirds of contracepting women in Brazil used dual protection (40% exclusive condoms, 27% dual methods). Consistent condom use in the past year occurred among 61% of exclusive condom users and 27% of dual method users. Dual methods (vs exclusive condoms) was associated with some high school education [relative risk ratio (RRR)=1.69,p<0.05], living in the Southern region (RRR=1.59,p<0.01), and number of children (RRR=1.22,p<0.01), net of other factors. Consistent condom use was associated with condom use at sexual debut [adjusted odds ratio (AOR)=1.84,p<0.001], wants no (more) children (AOR=1.86,p<0.001), single/separated relationship status (AOR=2.77/2.45,p<0.001) and using exclusive condoms (vs dual methods: AOR=0.19,p<0.001).ConclusionsFindings highlight that targeting and delivering integrated HIV and family planning services should focus on completed/large families. single/separated individuals, and promoting dual protection at sexual debut.
Overcoming EGFR Bypass Signal-Induced Acquired Resistance to ALK Tyrosine Kinase Inhibitors in ALK-Translocated Lung Cancer
Authors: Miyawaki Masayoshi , Yasuda Hiroyuki , Tani Tetsuo , Hamamoto Junko , Arai Daisuke , Ishioka Kota , Ohgino Keiko , Nukaga Shigenari , Hirano Toshiyuki , Kawada Ichiro , Naoki Katsuhiko , Hayashi Yuichiro , Betsuyaku Tomoko , Soejima Kenzo 
Published: October 2016

Abstract
Activation of the EGFR pathway is one of the mechanisms inducing acquired resistance to anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) such as crizotinib and alectinib. Ceritinib is a highly selective ALK inhibitor and shows promising efficacy in non–small cell lung cancers (NSCLC) harboring the ALK gene rearrangement. However, the precise mechanism underlying acquired resistance to ceritinib is not well-defined. This study set out to clarify the mechanism in ALK-translocated lung cancer and to find the preclinical rationale overcoming EGFR pathway–induced acquired resistance to ALK-TKIs. To this end, ceritinib-resistant cells (H3122-CER) were established from the H3122 NSCLC cell line harboring the ALK gene rearrangement via long-term exposure to ceritinib. H3122-CER cells acquired resistance to ceritinib through EGFR bypass pathway activation. Furthermore, H3122 cells that became resistant to ceritinib or alectinib through EGFR pathway activation showed cross-resistance to other ALK-TKIs. Ceritinib and afatinib combination treatment partially restored the sensitivity to ceritinib.
Implications: This study proposes a preclinical rationale to use ALK-TKIs and afatinib combination therapy for ALK-translocated lung cancers that have acquired resistance to ALK-TKIs through EGFR pathway activation. Mol Cancer Res; 15(1); 106–14. ©2016 AACR.
Combination of Thrombolysis and Statins in Acute Stroke Is Safe
Authors: Montaner Joan , Bustamante Alejandro , García-Matas Silvia , Martínez-Zabaleta Maite , Jiménez Carmen , de la Torre Javier , Rubio Francisco R. , Segura Tomás , Masjuán Jaime , Cánovas David , Freijo Mar , Delgado-Mederos Raquel , Tejada Javier , Lago Aida , Bravo Yolanda , Corbeto Natália , Giralt Dolors , Vives-Pastor Bárbara , de Arce Anna , Moniche Francisco , Delgado Pilar , Ribó Marc 
Published: October 2016

Background and Purpose—
The STARS trial (Stroke Treatment With Acute Reperfusion and Simvastatin) was conducted to demonstrate the efficacy and safety of simvastatin treatment in acute stroke.

Methods—
STARS07 was a multicentre, phase IV, prospective, randomized, double-blind, placebo-controlled trial. Patients with Acute ischemic stroke recruited within 12 hours from symptom onset were randomized to oral simvastatin 40 mg or placebo, once daily for 90 days. Primary outcome was proportion of independent patients (modified Rankin Scale score of ≤2) at 90 days. Safety end points were hemorrhagic transformation, hemorrhagic events, death, infections, and serious adverse events.

Results—

From April 2009 to March 2014, 104 patients were included. Fifty-five patients received intravenous tissue-type plasminogen activator. No differences were found between treatment arms regarding the primary outcome (adjusted odds ratio, 0.99 [0.35–2.78];
P
=0.98). Concerning safety, no significant differences were found in the rate of hemorrhagic transformation of any type, nor symptomatic hemorrhagic transformation. There were no differences in other predefined safety outcomes. In post hoc analyses, for patients receiving tissue-type plasminogen activator, a favorable effect for simvastatin treatment was noted with higher proportion of patients experiencing major neurological recovery (adjusted odds ratio, 4.14 [1.18–14.4];
P
=0.02).

Conclusions—
Simvastatin plus tissue-type plasminogen activator combination seems safe in acute stroke, with low rates of bleeding complications. Because of the low recruitment, the STARS trial was underpowered to detect differences in simvastatin efficacy.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01073007.
Chronic headache with medication overuse: Long-term prognosis after withdrawal therapy
Authors: Bøe Magne Geir , Thortveit Erik , Vatne Anita , Mygland Åse 
Published: October 2016

Background Knowledge about long-term outcomes after medication withdrawal therapy for chronic headache, including tension type and migraine headache is lacking. Methods We re-examined 56 patients an average of nine years after they participated in a medication withdrawal study with a one-year follow-up. We collected and compared data on headache, use of medication, quality of life, quality of sleep, anxiety, depression, and labor participation one and nine years after the start of withdrawal therapy. Results Headache days per month decreased from 16.7 (14.0–19.3) at one year to 13.3 (10.6–15.9) at nine years (P = 0.007). The proportion of patients meeting the criteria for chronic headache decreased from 27/56 (48%) at one year to 18/56 (32%) at nine years (P = 0.004). Medication overuse was reported in seven (13%) patients at one year and 18 (32%) at nine years (P = 0.013). The majority of patients overusing medication at nine years (10/18) belonged to a group of 14 patients who had a poor early response to withdrawal therapy and had sustained chronic headache after nine years. After excluding patients receiving retirement pensions, the proportion who received disability benefits increased from 21/55 (38%) at one year to 30/49 (61%) at nine years (P = 0.003). Conclusion Improvements after withdrawal therapy for chronic headache last at least nine years, with a parallel increase in the use of disability benefits. However, a high proportion of patients with a poor initial response to withdrawal therapy and sustained chronic headache overuse medication.
Smoke-Free Men: Competing and Connecting to Quit
Authors: Bottorff Joan L. , Oliffe John L. , Sarbit Gayl , Sharp Paul , Kelly Mary T. 
Published: October 2016

Purpose: The purpose of this study was to explore gender-related factors that motivate and support men’s smoking reduction and cessation to inform effective men-centered interventions. Approach or Design: Focus group design using a semi-structured interview guide. Setting: Three communities in British Columbia, Canada. Participants: A total of 56 men who currently smoked and were interested in reducing or quitting or had quit. Intervention: N/A. Methods: Data collected in 6 focus group discussions were transcribed and analyzed in accord with principles of thematic qualitative methods. Results: We report the results across 4 interconnected themes: (1) the fight to quit takes several rounds, (2) the motivation of supportive competition, (3) challenges and benefits of connecting with smoke-free peers, and (4) playing up the physical and financial gains. Conclusions: Masculine-based perspectives positioned quitting alongside fighting for self-control, competing, connecting, physical prowess, and having extra cash as motivating components of programs to engage men in efforts to be smoke-free. It may be worthwhile to consider the inclusion of gain-framed and benefit-focused messaging in programs that support men’s tobacco cessation.
Participatory Experiences of Women in Economic Development Cooperatives in Bhambayi, KwaZulu-Natal, South Africa
Authors: Raniga Tanusha 
Published: October 2016

Purpose: Nation states in both the Global North and South have debated the human rights and liberatory function as opposed to the dependency and economically viable function of social protection policy. This article is an attempt to advance empirical knowledge in the field of social protection policy and poverty alleviation. Method: Using participatory action methodology, I present evidence from 11 women who were involved in an arts and craft economic development cooperative in a community named Bhambayi in KwaZulu-Natal, South Africa. Results: Underscored by the asset-based community development and sustainable livelihood frameworks, this article presents three themes: positive contributions to human capacity development, supportive intersectoral collaboration, and striving for economic self-reliance. Conclusions: This article proposes fresh strategies for women who find themselves outside the circle of secure economic livelihoods to move beyond short-term and survival strategies and work toward economic inclusion.
Romidepsin-associated cardiac toxicity and ECG changes: A case report and review of the literature
Authors: Rivers Zachary T , Oostra Drew R , Westholder James S , Vercellotti Gregory M 
Published: October 2016

Background Romidepsin is a novel histone deacetylase inhibitor that is approved for the treatment of cutaneous and peripheral T-cell lymphoma in patients who have had at least one prior therapy. Romidepsin is generally well tolerated, though it comes with a risk of cardiac toxicities. Objective We report a case of electrocardiogram changes in a 64-year-old male with enteropathy-associated T-cell lymphoma, type 2, treated with salvage romidepsin therapy who relapsed after non-myeloablative allogeneic sibling peripheral blood stem cell transplant. Discussion Although histone deacetylase inhibitors have been investigated for many years, they have only recently been translated to clinical use as a therapy for malignancies. Furthermore, given their approval for a rare disease, clinicians often have limited experience with the dosing and side effects of histone deacetylase inhibitors. Conclusion This case report and literature review investigates the cardiac side effects of histone deacetylase inhibitors and illustrates the importance of cardiac monitoring prior to and during treatment.
Parametric bootstrapping for biological sequence motifs
Authors: O’Neill Patrick K. , Erill Ivan 
Published: October 2016

Abstract
Background
Biological sequence motifs drive the specific interactions of proteins and nucleic acids. Accordingly, the effective computational discovery and analysis of such motifs is a central theme in bioinformatics. Many practical questions about the properties of motifs can be recast as random sampling problems. In this light, the task is to determine for a given motif whether a certain feature of interest is statistically unusual among relevantly similar alternatives. Despite the generality of this framework, its use has been frustrated by the difficulties of defining an appropriate reference class of motifs for comparison and of sampling from it effectively.

Results
We define two distributions over the space of all motifs of given dimension. The first is the maximum entropy distribution subject to mean information content, and the second is the truncated uniform distribution over all motifs having information content within a given interval. We derive exact sampling algorithms for each. As a proof of concept, we employ these sampling methods to analyze a broad collection of prokaryotic and eukaryotic transcription factor binding site motifs. In addition to positional information content, we consider the informational Gini coefficient of the motif, a measure of the degree to which information is evenly distributed throughout a motif’s positions. We find that both prokaryotic and eukaryotic motifs tend to exhibit higher informational Gini coefficients (IGC) than would be expected by chance under either reference distribution. As a second application, we apply maximum entropy sampling to the motif p-value problem and use it to give elementary derivations of two new estimators.

Conclusions
Despite the historical centrality of biological sequence motif analysis, this study constitutes to our knowledge the first use of principled null hypotheses for sequence motifs given information content. Through their use, we are able to characterize for the first time differerences in global motif statistics between biological motifs and their null distributions. In particular, we observe that biological sequence motifs show an unusual distribution of IGC, presumably due to biochemical constraints on the mechanisms of direct read-out.
Identification of large disjoint motifs in biological networks
Authors: Elhesha Rasha , Kahveci Tamer 
Published: October 2016

Abstract
Background
Biological networks provide great potential to understand how cells function. Network motifs, frequent topological patterns, are key structures through which biological networks operate. Finding motifs in biological networks remains to be computationally challenging task as the size of the motif and the underlying network grow. Often, different copies of a given motif topology in a network share nodes or edges. Counting such overlapping copies introduces significant problems in motif identification.

Results
In this paper, we develop a scalable algorithm for finding network motifs. Unlike most of the existing studies, our algorithm counts independent copies of each motif topology. We introduce a set of small patterns and prove that we can construct any larger pattern by joining those patterns iteratively. By iteratively joining already identified motifs with those patterns, our algorithm avoids (i) constructing topologies which do not exist in the target network (ii) repeatedly counting the frequency of the motifs generated in subsequent iterations. Our experiments on real and synthetic networks demonstrate that our method is significantly faster and more accurate than the existing methods including SUBDUE and FSG.

Conclusions
We conclude that our method for finding network motifs is scalable and computationally feasible for large motif sizes and a broad range of networks with different sizes and densities. We proved that any motif with four or more edges can be constructed as a join of the small patterns.
A decision analysis model for KEGG pathway analysis
Authors: Du Junli , Li Manlin , Yuan Zhifa , Guo Mancai , Song Jiuzhou , Xie Xiaozhen , Chen Yulin 
Published: October 2016

Abstract
Background
The knowledge base-driven pathway analysis is becoming the first choice for many investigators, in that it not only can reduce the complexity of functional analysis by grouping thousands of genes into just several hundred pathways, but also can increase the explanatory power for the experiment by identifying active pathways in different conditions. However, current approaches are designed to analyze a biological system assuming that each pathway is independent of the other pathways.

Results
A decision analysis model is developed in this article that accounts for dependence among pathways in time-course experiments and multiple treatments experiments. This model introduces a decision coefficient—a designed index, to identify the most relevant pathways in a given experiment by taking into account not only the direct determination factor of each Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway itself, but also the indirect determination factors from its related pathways. Meanwhile, the direct and indirect determination factors of each pathway are employed to demonstrate the regulation mechanisms among KEGG pathways, and the sign of decision coefficient can be used to preliminarily estimate the impact direction of each KEGG pathway. The simulation study of decision analysis demonstrated the application of decision analysis model for KEGG pathway analysis.

Conclusions
A microarray dataset from bovine mammary tissue over entire lactation cycle was used to further illustrate our strategy. The results showed that the decision analysis model can provide the promising and more biologically meaningful results. Therefore, the decision analysis model is an initial attempt of optimizing pathway analysis methodology.