bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bortezomib, Doxorubicin, Cyclophosphamide, Dexamethasone Induction Followed by Stem Cell Transplantation for Primary Plasma Cell Leukemia: A Prospective Phase II Study of the Intergroupe Francophone du Myélome
Authors: Royer Bruno , Minvielle Stéphane , Diouf Momar , Roussel Murielle , Karlin Lionel , Hulin Cyrille , Arnulf Bertrand , Macro Margaret , Cailleres Sylvie , Brion Annie , Brechignac Sabine , Belhadj Karim , Chretien Marie Lorraine , Wetterwald Marc , Chaleteix Carine , Tiab Mourad , Leleu Xavier , Frenzel Laurent , Garderet Laurent , Choquet Sylvain , Fuzibet Jean Gabriel , Dauriac Charles , Forneker Luc-Matthieu , Benboubker Lotfi , Facon Thierry , Moreau Philippe , Avet-Loiseau Hervé , Marolleau Jean Pierre 
Published: April 2016

Purpose Primary plasma cell leukemia (pPCL) is a rare and aggressive malignancy with a poor prognosis. With conventional chemotherapy, patients typically die within 1 year. In all but one of the retrospective studies reported to date, bortezomib and lenalidomide seem to improve survival. We conducted a prospective phase II trial in patients with pPCL to assess the efficacy of an alternate regimen that combines standard chemotherapy, a proteasome inhibitor, and high-dose melphalan and autologous stem cell transplantation (HDM/ASCT) followed by either allogeneic transplantation or bortezomib/lenalidomide maintenance. Patients and Methods Patients 70 years old and younger with newly diagnosed pPCL received four alternating cycles of bortezomib, dexamethasone plus doxorubicin or cyclophosphamide. Peripheral blood stem cells were collected from responding patients with < 1% of circulating plasma cells before HDM/ASCT. As consolidation, young patients received a reduced-intensity conditioning allograft, whereas the remaining patients underwent a second HDM/ASCT followed by 1 year of bortezomib, lenalidomide, dexamethasone. The primary end point was progression-free survival (PFS). Results Forty patients (median age, 57 years; range, 27 to 71 years) were enrolled. The median follow-up was 28.7 months. In the intention-to-treat analysis, the median PFS and overall survival were 15.1 (95% CI, 8.4; -) and 36.3 (95% CI, 25.6; -) months, respectively. The overall response rate to induction was 69%. One patient underwent a syngeneic allograft and 25 HDM/ASCT (16 of whom subsequently received a reduced-intensity conditioning allograft and seven a second ASCT followed by maintenance). Conclusion In this prospective trial in patients with pPCL, we show that bortezomib, dexamethasone plus doxorubicin or cyclophosphamide induction followed by transplantation induces high response rates and appears to significantly improve PFS.
European Collaborative Study Defining Clinical Profile Outcomes and Novel Prognostic Criteria in Monoclonal Immunoglobulin M–Related Light Chain Amyloidosis
Authors: Sachchithanantham Sajitha , Roussel Murielle , Palladini Giovanni , Klersy Catherine , Mahmood Shameem , Venner Christopher Paul , Gibbs Simon , Gillmore Julian , Lachmann Helen , Hawkins Philip N. , Jaccard Arnaud , Merlini Giampaolo , Wechalekar Ashutosh D. 
Published: April 2016

Purpose Immunoglobulin M (IgM)–related light chain (AL) amyloidosis, which accounts for 6% to 10% of all AL amyloidosis cases, is a rare and poorly studied clinical entity. Its natural history and management is not clearly defined. Prognostic and response criteria for AL amyloidosis in general have not been validated in this population. Patients and Methods We retrospectively gathered data for 250 patients diagnosed with IgM AL amyloidosis from three European amyloidosis centers. Clinical features, hematologic response, and overall survival (OS) were analyzed. The current staging and response criteria in non-IgM AL amyloidosis was applied to this series to assess its utility in this patient cohort. Results Patients with IgM AL amyloidosis have a significant IgM paraprotein (median, 10 g/L), less frequent lambda light chain isotype, and evaluable difference between involved and uninvolved free light chains (dFLCs; > 50 mg/L) in only two thirds of patients. Bone marrow showed clear non-Hodgkin lymphoma as the underlying disorder in 54% of patients. Cardiac involvement (45%) is less common but there is more frequent lymph node (20%) and neuropathic (28%) involvement compared with non-IgM AL. Fifty-seven percent of patients achieved a hematologic response (14% very good partial response/complete response [VGPR/CR]), with median OS not reached for patients achieving VGPR/CR, 64 months for PR, and 28 months for nonresponders (P < .001). On multivariate analysis, cardiac involvement, advanced Mayo disease stage, neuropathic involvement, and liver involvement were independent factors that had an impact on survival. Combining abnormal N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin T with liver involvement and the presence of neuropathy gives a better risk model: median OS of patients with none, one, or two or more abnormal factors was 90, 33, and 16 months, respectively. Conclusion IgM AL amyloidosis is a distinct clinical entity. Low-risk disease can be defined by combining cardiac involvement with novel prognostic markers. Deeper hematologic responses translate into improved outcomes, yet deep responses remain dismally poor, which highlights the urgent need for novel therapies.
Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers
Authors: Vasen Hans , Ibrahim Isaura , Ponce Carmen Guillen , Slater Emily P. , Matthäi Elvira , Carrato Alfredo , Earl Julie , Robbers Kristin , van Mil Anneke M. , Potjer Thomas , Bonsing Bert A. , de Vos tot Nederveen Cappel Wouter H. , Bergman Wilma , Wasser Martin , Morreau Hans , Klöppel Günter , Schicker Christoph , Steinkamp Martin , Figiel Jens , Esposito Irene , Mocci Evelina , Vazquez-Sequeiros Enrique , Sanjuanbenito Alfonso , Muñoz-Beltran Maria , Montans José , Langer Peter , Fendrich Volker , Bartsch Detlef K. 
Published: April 2016

Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Hereditary factors play a role in the development of PDAC in 3% to 5% of all patients. Surveillance of high-risk groups, may facilitate detection of PDAC at an early stage. The aim of this study was to assess whether surveillance aids detection of early-stage PDAC or precursor lesions (PRLs) and improves the prognosis. Patients and Methods Screening outcomes were collected from three European centers that conduct prospective screening in high-risk groups including families with clustering of PDAC (familial pancreatic cancer [FPC]) or families with a gene defect that predisposes to PDAC. The surveillance program consisted of annual magnetic resonance imaging, magnetic resonance cholangiopancreatography, and/or endoscopic ultrasound. Results Four hundred eleven asymptomatic individuals participated in the surveillance programs, including 178 CDKN2A mutation carriers, 214 individuals with FPC, and 19 BRCA1/2 or PALB2 mutation carriers. PDAC was detected in 13 (7.3%) of 178 CDKN2A mutation carriers. The resection rate was 75%, and the 5-year survival rate was 24%. Two CDKN2A mutation carriers (1%) underwent surgical resection for low-risk PRL. Two individuals (0.9%) in the FPC cohort had a pancreatic tumor, including one advanced PDAC and one early grade 2 neuroendocrine tumor. Thirteen individuals with FPC (6.1%) underwent surgical resection for a suspected PRL, but only four (1.9%) had high-risk lesions (ie, high-grade intraductal papillary mucinous neoplasms or grade 3 pancreatic intraepithelial neoplasms). One BRCA2 mutation carrier was found to have PDAC, and another BRCA2 mutation carrier and a PALB2 mutation carrier underwent surgery and were found to have low-risk PRL. No serious complications occurred as consequence of the program. Conclusion Surveillance of CDNK2A mutation carriers is relatively successful, detecting most PDACs at a resectable stage. The benefit of surveillance in families with FPC is less evident.
Eight Cycles of ABVD Versus Four Cycles of BEACOPPescalatedPlus Four Cycles of BEACOPPbaselinein Stage III to IV, International Prognostic Score ≥ 3, High-Risk Hodgkin Lymphoma: First Results of the Phase III EORTC 20012 Intergroup Trial
Authors: Carde Patrice , Karrasch Matthias , Fortpied Catherine , Brice Pauline , Khaled Hussein , Casasnovas Olivier , Caillot Denis , Gaillard Isabelle , Bologna Serge , Ferme Christophe , Lugtenburg Pieternella Johanna , Morschhauser Frank , Aurer Igor , Coiffier Bertrand , Meyer Ralph , Seftel Matthew , Wolf Max , Glimelius Bengt , Sureda Anna , Mounier Nicolas 
Published: April 2016

PurposeTo compare patients with high-risk stage III to IV Hodgkin lymphoma (HL) in the phase III European Organisation for Research and Treatment of Cancer 20012 Intergroup trial (Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Stage III or Stage IV Hodgkin’s Lymphoma) who were randomly assigned to either doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) or to bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP).Patients and MethodsPatients with clinical stage III or IV HL, International Prognostic Score of 3 or higher, and age 60 years or younger received ABVD for eight cycles (ABVD8) or escalated-dose BEACOPP (BEACOPPescalated) for four cycles followed by baseline BEACOPP (BEACOPPbaseline) for four cycles (BEACOPP4+4) without radiotherapy. Primary end points were event-free survival (EFS), treatment discontinuation, no complete response (CR) or unconfirmed complete response (CRu) after eight cycles, progression, relapse, or death. Secondary end points were CR rate, overall survival (OS), quality of life, secondary malignancies, and disease-free survival in CR/CRu patients.ResultsBetween 2002 and 2010, 549 patients were randomly assigned to ABVD8(n = 275) or BEACOPP4+4(n = 274). Other characteristics included median age, 35 years; male, 75%; stage IV, 74%; “B” symptoms, 81%; and International Prognostic Score ≥ 4, 59%. WHO performance status was 0 (34%), 1 (48%), or 2 (17%). Median follow-up was 3.6 years. CR/CRu was 82.5% in both arms. At 4 years, EFS was 63.7% for ABVD8versus 69.3% for BEACOPP4+4(hazard ratio [HR], 0.86; 95% CI, 0.64 to 1.15; P = .312); disease-free survival was 85.8% versus 91.0% (HR, 0.59; 95% CI, 0.33 to 1.06; P = .076), and OS was 86.7% versus 90.3% (HR, 0.71; 95% CI, 0.42 to 1.21; P = .208). Death as a result of toxicity occurred in six and five patients, early discontinuation (before cycle 5) in 12 and 26 patients, treatment crossovers in five and 10 patients, and secondary malignancies in eight and 10 patients in the ABVD8and BEACOPP4+4arms, respectively.ConclusionABVD8and BEACOPP4+4resulted in similar EFS and OS in patients with high-risk advanced-stage HL. Because BEACOPP4+4did not demonstrate a favorable effectiveness or toxicity ratio compared with ABVD8, treatment burden, immediate and late toxicities, and associated costs must be considered before selecting one of these regimens on which to build future treatment strategies.
Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes
Authors: Furst Jessica R. , Bandeira Leonardo C. , Fan Wen-Wei , Agarwal Sanchita , Nishiyama Kyle K. , McMahon Donald J. , Dworakowski Elzbieta , Jiang Hongfeng , Silverberg Shonni J. , Rubin Mishaela R. 
Published: April 2016

AbstractContext:Skeletal deterioration, leading to an increased risk of fracture, is a known complication of type 2 diabetes mellitus (T2D). Yet plausible mechanisms to account for skeletal fragility in T2D have not been clearly established.Objective:The objective of the study was to determine whether bone material properties, as measured by reference point indentation, and advanced glycation endproducts (AGEs), as determined by skin autofluorescence (SAF), are related in patients with T2D.Design:This was a cross-sectional study.Setting:The study was conducted at a tertiary medical center.Patients:Sixteen postmenopausal women with T2D and 19 matched controls participated in the study.Main Outcome Measures:Bone material strength index (BMSi) by in vivo reference point indentation, AGE accumulation by SAF, and circulating bone turnover markers were measured.Results:BMSi was reduced by 9.2% in T2D (P = .02) and was inversely associated with the duration of T2D (r = −0.68, P = .004). Increased SAF was associated with reduced BMSi (r = −0.65, P = .006) and lower bone formation marker procollagen type 1 amino-terminal propeptide (r = −0.63, P = .01) in T2D, whereas no associations were seen in controls. SAF accounted for 26% of the age-adjusted variance in BMSi in T2D (P = .03).Conclusions:Bone material properties are impaired in postmenopausal women with T2D as determined by reference point indentation. The results suggest a role for the accumulation of AGEs to account for inferior BMSi in T2D.
The Two Enslavements of Rufina: Slavery and International Relations on the Southern Border of Nineteenth-Century Brazil
Authors: Grinberg Keila 
Published: April 2016

AbstractAs the Atlantic slave trade came to an end in Brazil in the 1850s, a new form of trafficking began across the borders of Brazil and its neighboring countries. Free persons—mainly women and children living in small communities in Uruguay and Argentina—were kidnapped to be sold as slaves in Brazil. By analyzing the illegal enslavement of the African Rufina and her family along the border between Brazil and Uruguay in 1854, this study argues that Brazilian catchers opened up a new frontier of enslavement, kidnapping free persons in countries where slavery was already abolished. The kidnappings and the diplomatic problems that they generated brought tensions to the development of international relations between Brazil, Uruguay, Argentina, and Britain in the 1850s and 1860s.
Simultaneous optimisation of earwig hindwings for flight and folding
Authors: Deiters Julia , Kowalczyk Wojciech , Seidl Tobias 
Published: April 2016

ABSTRACTEarwig wings are highly foldable structures that lack internal muscles. The behaviour and shape changes of the wings during flight are yet unknown. We assume that they meet a great structural challenge to control the occurring deformations and prevent the wing from collapsing. At the folding structures especially, the wing could easily yield to the pressure. Detailed microscopy studies reveal adaptions in the structure and material which are not relevant for folding purposes. The wing is parted into two structurally different areas with, for example, a different trend or stiffness of the wing veins. The storage of stiff or more flexible material shows critical areas which undergo great changes or stress during flight. We verified this with high-speed video recordings. These reveal the extent of the occurring deformations and their locations, and support our assumptions. The video recordings reveal a dynamical change of a concave flexion line. In the static unfolded state, this flexion line blocks a folding line, so that the wing stays unfolded. However, during flight it extends and blocks a second critical folding line and prevents the wing from collapsing. With these results, more insight in passive wing control, especially within high foldable structures, is gained.
Gastrointestinal stem cells in health and disease: from flies to humans
Authors: Li Hongjie , Jasper Heinrich 
Published: April 2016

ABSTRACT
The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a series of specialized epithelia that are regenerated by specific populations of stem cells. To maintain tissue homeostasis, the proliferative activity of stem and/or progenitor cells has to be carefully controlled and coordinated with regionally distinct programs of differentiation. Metaplasias and dysplasias, precancerous lesions that commonly occur in the human gastrointestinal tract, are often associated with the aberrant proliferation and differentiation of stem and/or progenitor cells. The increasingly sophisticated characterization of stem cells in the gastrointestinal tract of mammals and of the fruit fly Drosophila has provided important new insights into these processes and into the mechanisms that drive epithelial dysfunction. In this Review, we discuss recent advances in our understanding of the establishment, maintenance and regulation of diverse intestinal stem cell lineages in the gastrointestinal tract of Drosophila and mice. We also discuss the field's current understanding of the pathogenesis of epithelial dysfunctions.
Using Websites and Social Networks by the Tourism Industry Subjects of the Republic of Crimea
Authors: Остапчук  , Ostapchuk Aleksey 
Published: April 2016

The article considers the tourism industry subjects of the Republic of Crimea
such as sanatorium-and-spa institutions, hotels and tour operators. The use
of websites and social networks for marketing communication by these
organizations is analyzed.
Further was determined share of the enterprises what have own websites and
systems online booking related with websites. The author analyzed activity in use
of websites and social networks sanatoriums, hotels and tour operators. The
author identifies the most popular social networks for organizations of the tourism
industry Crimean Republic. It is shown of number subscribers to the pages in the
social networks of considered organizations.
Single Stage Aortic Arch Replacement without Circulatory Arrest
Authors: Marenchino Ricardo , Domenech Alberto 
Published: April 2016

AbstractA 78-year-old man with a Kommerell diverticulum and aberrant right subclavian artery was admitted for thoracic pain and severe malnutrition due to esophageal compression. We performed an atypical surgical procedure including extra-anatomical debranching and direct aortic repair, trying to avoid deep hypothermic circulatory arrest and shorten the cardiopulmonary bypass time.
Comparative Analysis of Primary Forest Products Export in the United States and China Using a Constant Market Share Model
Authors: Wu Jinzhuo , Wang Jingxin , Lin Wenshu 
Published: April 2016

Abstract
The export changes of primary forest products in the United States and China from 2005 through 2012 were compared, and a constant market share model was applied to analyze the impact factors on the export variations of the two countries. The results showed that the decline of import scale and structural changes of the target markets had a negative impact on the wood products export of the two countries. The export variations of primary forest products in the two countries were significantly different. While a small increase in the export of primary forest products was demonstrated in the United States, China's export increased significantly, especially to the major export markets. The change in competitiveness of forest products exports during this time period differed in these two countries. The competitiveness of forest products from the United States remained stable with slight variation; however, the forest products exported by China showed a strong increasing competitive trend.
A Novel Peptidomic Approach to Strain Typing of Clinical Acinetobacter baumannii Isolates Using Mass Spectrometry
Authors: Wang Honghui , Drake Steven K , Yong Chen , Gucek Marjan , Tropea Margaret , Rosenberg Avi Z , Dekker John P , Suffredini Anthony F 
Published: April 2016

Abstract

BACKGROUND
Acinetobacter baumannii is a common nosocomial pathogen and strain-typing methods play an important role in hospital outbreak investigations and epidemiologic surveillance. We describe a method for identifying strain-specific peptide markers based on LC-MS/MS profiling of digested peptides. This method classified a test set of A. baumannii isolates collected from a hospital outbreak with discriminatory performance exceeding that of MALDI-TOF mass spectrometry.

METHODS
Following the construction of a species “pan-peptidome” by in silico translation and digestion of whole genome sequences, a hypothetical set of genome-specific peptides for an isolate was constructed from the disjoint set of the pan-peptidome and the isolate's calculated peptidome. The genome-specific peptidome guided selection of highly expressed genome-specific peptides from LC-MS/MS experimental profiles as potential peptide markers. The species specificity of each experimentally identified genome-specific peptide was confirmed through a Unipept lowest common ancestor analysis.

RESULTS
Fifteen A. baumannii isolates were analyzed to derive a set of genome- and species-specific peptides that could be used as peptide markers. Identified peptides were cross-checked with protein BLAST against a set of 22 A. baumannii whole genome sequences. A subset of these peptide markers was confirmed to be present in the actual peptide profiles generated by multiple reaction monitoring and targeted LC-MS/MS. The experimentally identified peptides separated these isolates into 6 strains that agreed with multilocus sequence typing analysis performed on the same isolates.

CONCLUSIONS
This approach may be generalizable to other bacterial species, and the peptides may be useful for rapid MS strain tracking of isolates with broad application to infectious disease diagnosis.
The keyword search method and its importance in computer forensics <p>Adli bilişimde anahtar kelime araması metodu ve önemi
Authors: Çakır Huseyin , Kılıç Mehmet Serkan 
Published: April 2016

In this study “keyword search method” used in the filed of digital forensics sciences is investigated. Similar to using search engines on internet investigations, using keyword search method of computer forensics investigations has too much benefits. In the study, keyword search method loop of preparing of electronic data, indexing, query with keywords, matching on database and showing results to the users are explained. Also information of keyword search method on different data type such as forensic image data, live forensics data, static data and cloud computing data are discussed.The importance of using keyword search method on computer forensics is examined in 5 different aspect as rapid and effective computer forensics investigations, contribution to privacy, relational analysis of human-event-computing device, creating dictionary for decrypt passwords and recover some deleted data and detect steganography data. In this context, all-round about using keyword searches’ contribution to computer forensics investigation are evaluated. Finally, some examples about computer forensics tools are handled. ÖzetBu çalışmada, adli bilişim biliminde kullanılan “anahtar kelime araması metodu” incelenmiştir. İnternet araştırmalarında yaygın olarak kullanılan arama motorlarına benzer şekilde adli bilişim çalışmalarında da anahtar kelime araması metodu kullanılmasının çok faydası bulunmaktadır. Çalışmada; elektronik verilerin hazırlanması, verilerin indekslenmesi, anahtar kelimeler sorgusu, veri tabanı üzerinde eşleştirme yapılması ve kullanıcıya sonuçlarının gösterilmesi şeklinde oluşan anahtar kelime araması metodu açıklanmış ve adli kopya verileri, canlı sistem verileri, sabit veriler ve bulut bilişim verileri üzerinde anahtar kelime araması hakkında bilgi verilmiştir.Adli bilişim çalışmaları sürecinde anahtar kelime araması metodunun kullanımının önemi; hızlı ve etkili bir adli bilişim çalışması yapılması, özel hayatın gizliliğine katkı sağlaması, şahıs-olay-bilgisayar medyası arasında ilişki analizi kurulması, sözlük oluşturulması ve şifre tespiti ile silinmiş ve gizlenmiş verilerin tespiti olmak üzere 5 farklı açıdan irdelenmiştir. Bu bağlamda anahtar kelime araması metodunun elektronik delil elde etme çalışmalarına sağlayacağı katkı çok yönlü olarak ele alınmış ayrıca adli bilişim yazılımları özelinde örnekler verilmeye çalışılmıştır.