bluuebunny/crossref_metadata_2025_split huggingface dataset:
LA APLICACIÓN PÚBLICA DE LAS NORMAS DE LIBRE COMPETENCIA EN LA COMUNIDAD ANDINA Y SUS PAÍSES INTEGRANTES
Authors: Ortiz Baquero Ingrid S. , Solano Osorio Diego A. 
Published: September 2016

<p>La introducción de la aplicación privada o private enforcement en los diferentes sistemas jurídicos de derecho de la competencia presentes en el mundo, se ha dado tras un largo y consolidado desarrollo de la aplicación pública o public enforcement, que ve las acciones de daños como su complemento, más allá de considerarlas como su detractor. En este sentido, el presente documento pretende analizar el sistema público de cumplimiento de las normas del derecho de la competencia preponderante tanto en la Comunidad Andina, como en sus países integrantes y, de esta manera, identificar sus elementos característicos y evaluar las ventajas que ha traído a estos países el mantenimiento de este sistema. </p>
High-Quality Genome Assembly and Annotation for Plasmodium coatneyi, Generated Using Single-Molecule Real-Time PacBio Technology
Authors: Chien Jung-Ting , Pakala Suman B. , Geraldo Juliana A. , Lapp Stacey A. , Humphrey Jay C. , Barnwell John W. , Kissinger Jessica C. , Galinski Mary R. 
Published: September 2016

ABSTRACT

Plasmodium coatneyi
is a protozoan parasite species that causes simian malaria and is an excellent model for studying disease caused by the human malaria parasite,
P. falciparum
. Here we report the complete (nontelomeric) genome sequence of
P. coatneyi
Hackeri generated by the application of only Pacific Biosciences RS II (PacBio RS II) single-molecule real-time (SMRT) high-resolution sequence technology and assembly using the Hierarchical Genome Assembly Process (HGAP). This is the first
Plasmodium
genome sequence reported to use only PacBio technology. This approach has proven to be superior to short-read only approaches for this species.
Improved Complete Genome Sequence of the Extremely Radioresistant Bacterium Deinococcus radiodurans R1 Obtained Using PacBio Single-Molecule Sequencing
Authors: Hua Xiaoting , Hua Yuejin 
Published: September 2016

ABSTRACT

The genome sequence of
Deinococcus radiodurans
R1 was published in 1999. We resequenced
D. radiodurans
R1 using PacBio and compared the sequence with the published one. Large insertions and single nucleotide polymorphisms (SNPs) were observed among the genome sequences. A more accurate genome sequence will be helpful to studies of
D. radiodurans
.
Complete Genome Sequence of “
Candidatus
Viadribacter manganicus” Isolated from a German Floodplain Area
Authors: Braun Burga , Szewzyk Ulrich 
Published: September 2016

ABSTRACT

Iron- and manganese-depositing bacteria occur in many soils and all water systems, and their biogenic depositions of ochre in technical systems may cause severe clogging problems and monetary losses. “
Candidatus
Viadribacter manganicus” is a small coccoid, iron- and manganese-depositing bacterium isolated from the Lower Oder Valley National Park, Germany.
Whole-Genome Sequence of Aeromonas hydrophila Strain AH-1 (Serotype O11)
Authors: Forn-Cuní Gabriel , Tomás Juan M. , Merino Susana 
Published: September 2016

ABSTRACT

Aeromonas hydrophila
is an emerging pathogen of aquatic and terrestrial animals, including humans. Here, we report the whole-genome sequence of the septicemic
A. hydrophila
AH-1 strain, belonging to the serotype O11, and the first mesophilic
Aeromonas
with surface layer (S-layer) to be sequenced.
Low back pain among office workers in three Spanish-speaking countries: findings from the CUPID study
Authors: Campos-Fumero Adriana , Delclos George L , Douphrate David I , Felknor Sarah A , Vargas-Prada Sergio , Serra Consol , Coggon David , Gimeno Ruiz de Porras David 
Published: September 2016

ObjectivesTo assess the differences in the prevalence and incidence of low back pain (LBP) and associated disability among office workers in Costa Rica, Nicaragua and Spain.MethodsData were collected at baseline (n=947, 93% response) in November 2007 and at follow-up after 12 months (n=853, 90% response). Six outcome measures were examined: baseline prevalence of (1) LBP in the past 12 months, (2) LBP in the past month and (3) disabling LBP in the past month; and at follow-up: (4) incidence of new LBP in the past month, (5) new disabling LBP and (6) persistent LBP. Differences in prevalence by country were characterised by ORs with 95% CIs, before and after adjustment for covariates.ResultsPrevalence of LBP in the past month among office employees in Costa Rica (46.0%) and Nicaragua (44.2%) was higher than in Spain (33.6%). Incidence of new LBP was 37.0% in Nicaragua (OR=2.49; 95% CI 1.57 to 3.95), 14.9% in Costa Rica (OR=0.74; 95% CI 0.41 to 1.34) and 19.0% in Spain (reference). Incidence of new disabling LBP was higher in Nicaragua (17.2%; OR=2.49; 95% CI 1.43 to 4.34) and Costa Rica (13.6%; OR=1.89; 95% CI 1.03 to 3.48) than Spain (7.7%), while persistence of LBP was higher only in Nicaragua.ConclusionsPrevalence of LBP and disabling LBP was higher in Costa Rican and Nicaraguan office workers than in Spain, but the incidence was higher mainly in Nicaragua. Measured sociodemographic, job-related and health-related variables only partly explained the differences between countries, and further research is needed to explore reasons for the remaining differences.
Comparison of alpha decay with fission for isotopes of superheavy nuclei Z = 124
Authors: Manjunatha H. C. 
Published: September 2016

We have studied the [Formula: see text]-decay properties of superheavy nuclei (SHN) [Formula: see text] in the range [Formula: see text] using the Coulomb and proximity potential model for deformed nuclei (CPPMDN). The calculated [Formula: see text] half-lives agree with the values computed using the Viola–Seaborg systematic, the universal curve of Poenaru et al. [Phys. Rev. C 83 (2011) 014601; 85 (2012) 034615] and the analytical formulas of Royer [J. Phys. G[Formula: see text] Nucl. Part. Phys. 26 (2000) 1149]. To identify the mode of decay of these isotopes, the spontaneous-fission half-lives were also evaluated using the semiempirical relation given by Xu et al. [Phys. Rev. C 78 (2008) 044329]. The calculated half-lives help to predict the possible isotopes of this superheavy element [Formula: see text]. As we could observe [Formula: see text] chain consistently from the nuclei [Formula: see text]124, we have predicted that these nuclei could not be synthesized and detected experimentally via [Formula: see text] decay as their decay half-lives are too small. The nuclei [Formula: see text]124 were found to have long half-lives and hence could be sufficient to detect them if synthesized in a laboratory.
Subdividing three-dimensional Riemannian disks
Authors: Glynn-Adey Parker , Zhu Zhifei 
Published: September 2016

Papasoglu asked whether for any Riemannian 3-disk [Formula: see text] with diameter [Formula: see text], boundary area [Formula: see text] and volume [Formula: see text], there exists a homotopy [Formula: see text] contracting the boundary to a point so that the area of [Formula: see text] is bounded by [Formula: see text] for some function [Formula: see text]. He further asks whether it is possible to subdivide [Formula: see text] by a disk [Formula: see text] into two regions of volume [Formula: see text] so that the area of [Formula: see text] is bounded by some function [Formula: see text]. In this paper, we answer the questions above in the negative: We prove that given [Formula: see text] and [Formula: see text], one can construct a metric [Formula: see text] so that any 2-disk [Formula: see text] subdividing [Formula: see text] into two regions of volume at least [Formula: see text], the area of [Formula: see text] is greater than [Formula: see text]. We further prove that for any Riemannian 3-sphere [Formula: see text], there is a surface that subdivides the disk into two regions of volume no less than [Formula: see text], and the area of this surface is bounded by [Formula: see text], where [Formula: see text] is the homological filling function of [Formula: see text].
18F-fluoromisonidazole PET and Activity of Neoadjuvant Nintedanib in Early HER2-Negative Breast Cancer: A Window-of-Opportunity Randomized Trial
Authors: Quintela-Fandino Miguel , Lluch Ana , Manso Luis , Calvo Isabel , Cortes Javier , García-Saenz José Angel , Gil-Gil Miguel , Martinez-Jánez Noelia , Gonzalez-Martin Antonio , Adrover Encarna , de Andres Raquel , Viñas Gemma , Llombart-Cussac Antonio , Alba Emilio , Guerra Juan , Bermejo Begoña , Zamora Esther , Moreno-Anton Fernando , Pernas Simon Sonia , Carrato Alfredo , Lopez-Alonso Antonio , Escudero María José , Campo Ruth , Carrasco Eva , Palacios José , Mulero Francisca , Colomer Ramon 
Published: September 2016

Abstract
Purpose: We previously detected promising efficacy of neoadjuvant nintedanib (a multityrosine kinase inhibitor, TKI) in early HER2-negative breast cancer. In a preclinical study, we monitored stromal hypoxia with 18F-fluoromisonidazole-positron emission tomography (18F-FMISO-PET); we found that reoxygenation of tumors (or lack of it) during a window-of-opportunity (WoO) treatment with TKIs correlated with the benefit (or lack of it) from TKI-plus-chemotherapy combinations. We studied the predictive role of 18F-FMISO-PET for the TKI nintedanib in the neoadjuvant setting in a phase II WoO randomized trial.
Experimental Design: Patients were randomized to a 14-day WoO of nintedanib preceded and followed by an 18F-FMISO-PET, followed by nintedanib plus weekly paclitaxel (Arm A) or an 18F-FMISO-PET followed by weekly paclitaxel (Arm B) before surgery. The endpoint was residual cancer burden (RCB). The objective was to detect the patients with no response (RCB-III) on the basis of the baseline or evolutive 18F-FMISO-PET values/changes.
Results: One-hundred and thirty HER2-negative patients were randomized. Seventeen (27.9%), 34 (55.7%), and 8 (13.1%) patients had an RCB of III, II, and I/0, respectively, in Arm A. In this arm, baseline hypoxic tumors had a 4.4-fold higher chance of experiencing RCB = 3 (P = 0.036) compared with baseline normoxic tumors. Nintedanib WoO induced tumor reoxygenation in 24.5% of the patients; those not reoxygenating showed a trend toward higher chance of experiencing RCB-III (6.4-fold; P = 0.09). In Arm B, 18F-FMISO-PET lacked predictive/prognostic value.
Conclusions: Baseline hypoxic tumors (measured with 18F-FMISO-PET) do not benefit from neoadjuvant nintedanib. Clin Cancer Res; 23(6); 1432–41. ©2016 AACR.
Higher Glucose and Insulin Levels Are Associated with Risk of Liver Cancer and Chronic Liver Disease Mortality among Men without a History of Diabetes
Authors: Loftfield Erikka , Freedman Neal D. , Lai Gabriel Y. , Weinstein Stephanie J. , McGlynn Katherine A. , Taylor Philip R. , Männistö Satu , Albanes Demetrius , Stolzenberg-Solomon Rachael Z. 
Published: August 2016

Abstract
Insulin resistance likely increases the risk of chronic liver disease (CLD) and liver cancer, but long-term prospective studies with measured fasting glucose and insulin are lacking. We evaluated the associations of prediagnostic fasting glucose, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR) with liver cancer and CLD mortality in a prospective study of Finnish male smokers with extended follow-up time (≤22 years) and information on known risk factors using data from 138 incident primary liver cancer cases, 216 CLD deaths, and 681 matched controls. Fasting glucose and insulin were measured in baseline serum. We used unconditional logistic regression to estimate ORs and 95% confidence intervals adjusted for age, alcohol, education, smoking, body mass index, and hepatitis B and C viral status. Among those without self-reported diabetes, glucose was positively associated with liver cancer [quartile 3 vs. quartile 1 (Q3/Q1): OR = 1.88; 1.03–3.49; Q4/Q1: OR = 2.40; 1.33–4.35; Ptrend = 0.002], and undiagnosed, biochemically defined, diabetes was associated with higher risk of liver cancer (OR = 2.95; 1.46–5.96) and CLD mortality (OR = 1.88; 1.00–3.56). Serum insulin and HOMA-IR were also positively associated with liver cancer (Q4/Q1: OR = 3.41; 1.74–6.66; Ptrend &lt; 0.0001; OR = 3.72; 1.89–7.32, Ptrend &lt; 0.0001, respectively) and CLD (OR = 2.51; 1.44–4.37; Ptrend = 0.0002; OR = 2.31; 1.34–3.97; Ptrend = 0.001, respectively), with stronger associations observed for liver cancer diagnosed &gt;10 years after baseline. In conclusion, elevated fasting glucose and insulin and insulin resistance were independently associated with risk of liver cancer and CLD mortality, suggesting a potentially important etiologic role for insulin and glucose dysregulation even in the absence of diagnosed diabetes. Cancer Prev Res; 9(11); 866–74. ©2016 AACR.
Fluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state Experience Sampling Method
Authors: Van Calster Laurens , D'Argembeau Arnaud , Salmon Eric , Peters Frédéric , Majerus Steve 
Published: August 2016

Abstract
Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top–down versus bottom–up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes.
Constraining movement reveals motor capability in chronic stroke: an initial study
Authors: Martinez Clarisa A , Mintz Emily , Ecsedy Andrea E , Fisher Beth E 
Published: September 2016

Objective:To determine if persons with chronic stroke and decreased hip and knee flexion during swing can walk with improved swing-phase kinematics when the task demands constrained gait to the sagittal plane.Design:A one-day, within-subject design comparing gait kinematics under two conditions: Unconstrained treadmill walking and a constrained condition in which the treadmill walking space is reduced to limit limb advancement to occur in the sagittal plane.Setting:Outpatient physical therapy clinic.Subjects:Eight individuals (mean age, 64.1 ±9.3, 2 F) with mild-moderate paresis were enrolled.Main measures:Spatiotemporal gait characteristics and swing-phase hip and knee range of motion during unconstrained and constrained treadmill walking were compared using paired t-test and Cohen’s d ( d) to determine effect size.Results:There was a significant, moderate-to-large effect of the constraint on hip flexion ( p < 0.001, d = –1.1) during initial swing, and hip ( p < 0.05, d = –0.8) and knee ( p < 0.001, d = –1.1) flexion during midswing. There was a moderate effect of constraint on terminal swing knee flexion ( p = 0.238, d = –0.6). Immediate and significant changes in step width ( p < 0.05, d = 0.9) and paretic step length ( p < 0.05, d = –0.5) were noted in the constrained condition compared with unconstrained.Conclusion:Constraining the treadmill walking path altered the gait patterns among the study’s participants. The immediate change during constrained walking suggests that patients with chronic stroke may have underlying movement capability that they do not preferentially utilize.
Clinical features of migraine aura: Results from a prospective diary-aided study
Authors: Viana Michele , Sances Grazia , Linde Mattias , Ghiotto Natascia , Guaschino Elena , Allena Marta , Terrazzino Salvatore , Nappi Giuseppe , Goadsby Peter J , Tassorelli Cristina 
Published: August 2016

Background A detailed evaluation of migraine aura symptoms is crucial for classification issues and pathophysiological discussion. Few studies have focused on the detailed clinical aspects of migraine aura. Methods We conducted a prospective diary-based study of migraine aura features including presence, quality, laterality, duration of each aura symptom, their temporal succession; presence of headache and its temporal succession with aura. Results Seventy-two patients completed the study recording the characteristics of three consecutive auras ( n = 216 auras). Visual symptoms occurred in 212 (98%), sensory symptoms in 77 (36%) and dysphasic symptoms in 22 (10%). Most auras had more than one visual symptom (median 2, IQR 1–3, range 1–4). The majority of patients (56%) did not report a stereotyped aura on the three attacks with respect to visual features, the combination and/or temporal succession of the three aura symptoms. Fifty-seven percent of patients also reported a different scenario of temporal succession between aura and headache in the three attacks. Five per cent of aura symptoms were longer than four hours. Conclusion These findings show a high inter- and intravariability of migraine with aura attacks. Furthermore, they provide reliable data to enrich and clarify the spectrum of the aura phenotype.
Frequency of Eating Out at Both Fast-Food and Sit-Down Restaurants Was Associated With High Body Mass Index in Non-Large Metropolitan Communities in Midwest
Authors: Bhutani Surabhi , Schoeller Dale A. , Walsh Matthew C. , McWilliams Christine 
Published: August 2016

Purpose: We investigated the associations between frequency of eating at fast-food, fast-casual, all-you-can-eat, and sit-down restaurants and the body mass index (BMI) in non-large metro Wisconsin communities. To inform prevention efforts, we also analyzed the socioeconomic/environmental and nutrition attitudes/behavior variables that may drive the frequent eating away from home. Design: Cross-sectional analysis of an ancillary data set from the Survey of Health of Wisconsin collected between October 2012 and February 2013. Setting: Six Wisconsin counties: 1 classified as rural, 1 as large fringe metro, and 4 as small metro. Subjects: Adults ≥18 years (N = 1418). Measures: Field staff measured height and weight and administered a survey on the frequency of eating away from home, and socioeconomic and nutritional behavior variables. Analysis: Multivariable regression. Results: The BMI of respondents averaged 29.4 kg/m2 (39% obese). Every 1-meal/week increase in fast-food and sit-down restaurant consumption was associated with an increase in BMI by 0.8 and 0.6 kg/m2, respectively. Unavailability of healthy foods at shopping and eating venues and lack of cooking skills were both positively associated with consumption of fast-food and sit-down meals. Individuals who described their diet as healthy, who avoided high-fat foods, and who believed their diet was keeping their weight controlled did not visit these restaurants frequently. Conclusion: Obesity prevention efforts in non-large metro Wisconsin communities should consider socioeconomic/environmental and nutritional attitudes/behavior of residents when designing restaurant-based or community education interventions.
Moral distress and its influencing factors: A cross-sectional study in China
Authors: Wenwen Zhang , Xiaoyan Wu , Yufang Zhan , Lifeng Ci , Congcong Sun 
Published: September 2016

Objective: The purpose of this study was to describe the current situation of moral distress and to explore its influencing factors among Chinese nurses. Methods: This is an exploratory, descriptive design study. A total of 465 clinical nurses from different departments in three Grade-III, Level-A hospitals in Jinan, Shandong Province, completed the questionnaires, including demographics questionnaire, Chinese version of Moral Distress Scale–Revised, and Job Diagnostic Survey. Ethical considerations: The study was approved by the university ethics board and the local health service director. Results: The total score of Moral Distress Scale–Revised was 36.01 ± 24.02 points. The mean frequency and intensity scores of moral distress were 1.13 ± 0.49 and 1.09 ± 0.58, respectively. The level of moral distress among Chinese clinical nurses was low, and the frequency and intensity of moral distress were on low to moderate level. The level of moral distress experienced by clinical nurses is associated with demographics features and job characteristics, including age, education degree, department, task significance, autonomy, and dealing with others. Conclusion: Our conclusion suggests that hospital and organizational administrations should attach much importance to the moral distress experienced by clinical nurses in China. Further studies should focus on interventions about how to reduce the levels of the frequency and intensity of moral distress among clinical nurses.
Interdependence of oxysterols with cholesterol profiles in multiple sclerosis
Authors: Mukhopadhyay Shreya , Fellows Kelly , Browne Richard W , Khare Prachi , Krishnan Radhakrishnan Sandhya , Hagemeier Jesper , Weinstock-Guttman Bianca , Zivadinov Robert , Ramanathan Murali 
Published: September 2016

Purpose: To investigate levels of oxysterols in healthy control (HC) and multiple sclerosis (MS) patients and their interdependence with demographic, clinical characteristics, and cholesterol biomarkers. Methods: This study included 550 subjects (203 HC, 221 relapsing–remitting MS (RR-MS), 126 progressive MS (P-MS)). A complete lipid profile including total cholesterol (TC); high-density lipoprotein–cholesterol (HDL-C); low-density lipoprotein–cholesterol (LDL-C); apolipoproteins (Apo) A1, A2, B, and E; C-reactive protein (CRP); 24-hydroxycholesterol (HC); 25-HC; 27-HC; 7α-HC; and 7-ketocholesterol (KC) was obtained. Lipoprotein particle sizing by proton nuclear magnetic resonance (H1 NMR) was available for 432 subjects. Results: The levels of 24-HC, 27-HC, and 7α-HC (all p < 0.015) were lower in MS compared to HC, and 7-KC was higher in P-MS compared to RR-MS ( p < 0.001). TC, LDL-C, and ApoB were associated with higher levels of all oxysterols (all p < 0.05) in HC. In MS, LDL-C was associated with higher levels of 24-HC, 25-HC, 7-KC, and 7α-HC (all p < 0.05), while TC and ApoB were associated with increased levels of all oxysterols (all p < 0.005). Conclusion: The findings of lower 24-HC, 27-HC, and 7α-HC in MS compared to HC and higher 7-KC in P-MS compared to RR-MS indicate that the oxysterol network is disrupted in MS.