bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consideration of people’s design preferences for the development of adaptive user interfaces
Authors: Brandenburger Jessica , Janneck Monique 
Published: September 2024

Abstract
Adaptive user interfaces enable the display of user-specific, relevant information in complex interactive systems. The user experience on platforms can be improved by taking the user’s needs (goals, system experience, etc.) and design preferences (in terms of design shapes) into account. In a Germany-wide online survey, n = 1,044 young people (pupils and university students) aged between 14 and 35 were asked about their design shape preferences. The results show that, overall, the shape of the circle appears to be the most attractive for young people (14–35 years) and that gender and age have the greatest influence on design shape preferences. While men and generally older people (19–35 years, university students) prefer basic shapes to more complex shapes, women and generally younger people (14–19 years, pupils) find complex shapes more attractive than basic ones. The identification of preferences with regard to design shapes can provide developers of interactive systems with information for the design of (adaptive) user interfaces.
„Brexito“ įtaka arbitražui: anti suit injunction ir investicinio arbitražo aspektai
Authors: Okinčic Sebastjan 
Published: September 2024

Concentrating on a few material aspects in relation to the broader theme, the article analyses the effect of Brexit on international commercial arbitration. In particular, the piece firstly treats on the most recent UK Case Law in relation to anti-suit injunction – a phenomenon attributable to the Common Law in the context of the earlier European Union courts’ jurisprudence of the said instrument. Secondly, Brexit’s interplay with the ongoing global investment arbitration reform is considered. The article considers the globally recognised UN 1958 New York Convention on the Recognition and Enforcement of Foreign Arbitral Awards, on which Brexit had no adverse effect. When analysing the interplay between Brexit and the ongoing global investment arbitration reform, a particular regard is paid to the lack of investment arbitration provisions in the UK-EU Trade and Cooperation Agreement, as well as the termination of various relevant bilateral investment treaties. The article concludes that the influence of arbitration shall continue to grow, anti-suit injunction shall continue to be applied by the United Kingdom courts, and the Brexit’s interplay with the global investment protection overall and the investment arbitration in a particular reform is somewhat consistent.
Competition Dynamics of Market Share for Assets in the Banking Industry Using the Lotka-Volterra Model Approach
Authors: Jamal Sri Wahyuni , Suparno Suparno , Rashid Umi Kartini , Fauziah Fenty 
Published: September 2024

Research Originality: Competition in the banking sector is unavoidable. Such competition is present among state-owned banks in Indonesia. In contrast to the previous studies that did not include the competition type and its stability, this study includes the competition type and its stability in the estimation.Research Objectives: This study aims to discover the competition type and its stability, and to forecast the market share among the four state-owned banks.Research Methods: Using market share data of assets published annually by each of the banks from 2010 to 2023, the study employs the Lotka-Volterra model approach to analyze the competition type and its stability that occur among the four state-owned banks.Empirical Results: The study discovers that the competition types of the four state-owned banks vary. There have been three competition types among the four state-owned banks: mutualism, predator-prey and pure competition. Besides, the stability property of the four state-owned banks tended to be unstable. By looking at the gains of market share for assets, only Mandiri’s market share gains will increase in the 2024-2028 period. As a result, the total market share gains for the four state-owned banks declined sequentially.Implications:This research holds significance for four state-owned banks in Indonesia as it provides valuable insights into considering the three competition types (mutualism, pure competition and predator-prey) as the primary key to achieving a significant market share value.JEL Classification: C61, D41, E17, G21How to Cite:Jamal, S. W., Suparno., Rashid, U. K., & Fauziah, F. (2024). Competition Dynamics of Market Share for Assets in the Banking Industry Using the Lotka-Volterra Model Approach. Etikonomi, 23(2), 299 – 316. https://doi.org/10.15408/etk.v23i2.32226
Ubezpieczenie odpowiedzialności cywilnej członków władz spółki kapitałowej
Authors: Strupczewski Grzegorz 
Published: September 2024

D&O insurance is important both for board members, by securing them against civil liability, as well as creditors, as it strengthens their chances of being paid when a board member's personal assets prove insufficient. The purpose of this article is to analyse the general terms and conditions of D&O insurance available on the Polish market in order to identify differences in the proposed scope of coverage. The analysis is preceded by a description of legal sources of a director's and an officer's liability. The end of the article discusses current problems on tax issues related to D&O insurance premiums. The author concludes, among other things, that the recent economic crisis has forced entrepreneurs to take steps to improve efficiency while also limiting their exposure to risk. D&O insurance is undoubtedly an effective tool for supporting this strategy. Further development of the company liability insurance market segment (including D&O insurance) may therefore be expected, and hence the results of the paper have important theoretical and practical value.
METHODOLOGICAL APPROACHES TO THE ECONOMIC ASSESSMENT OF THE INNOVATIVE ACTIVITIES OF RAILWAY TRANSPORT
Authors: POLISHKO T.V. , KOSTIUK A.V. 
Published: September 2024

Objective. Justification of the need to improve the economic assessment of the innovative activity of railway transport, the development of methodological approaches and practical recommendations for the assessment of the innovative activity of railway transport, the study of requirements and assessment indicators characterizing the results of the implementation of innovations. Methods. Various methods and approaches were used in the process of performing the tasks in this work. The abstract-logical method was used to determine the research objectives. Analytical and monographic approach was used in the analysis of literary sources. The method of data analysis and synthesis for the analysis of existing methodological approaches and indicators. A comprehensive review and strategic analysis to describe promising directions for the innovative development of railway transport. Systemic, analogical, and structural-functional research methods for determining indicators of economic evaluation of innovative activity. Results. The article examines the main methodological approaches and proposes a new approach to the economic assessment of innovative activity. Scientific novelty. Recommendations on the use of an additional system of indicators for evaluating the innovative activity of railway transport are given. Practical significance. The recommendations given in the article regarding the use of the indicator system can be applied in railway transport units to make a decision on the introduction of innovations.
Perioperative Systemic Corticosteroids in Modern Total Hip and Knee Arthroplasty
Authors: Palmer Ryan C. , Jones Ian A. , Sculco Peter K. , Hannon Charles P. , Fillingham Yale A. , Heckmann Nathanael D. 
Published: September 2024

» Perioperative corticosteroids are strongly recommended for reducing the incidence and severity of postoperative nausea and vomiting following elective total hip or total knee arthroplasty.» Corticosteroids may reduce postoperative pain and opioid requirements. Similarly, corticosteroids appear to have a neutral-to-positive effect on length of stay, venous thromboembolism, mobility, delirium, acute kidney injury, and bone cement implantation syndrome (i.e., decreased length of stay).» Perioperative corticosteroids may induce hyperglycemia among both diabetic and nondiabetic patients; however, there is no strong evidence indicating that these transient corticosteroid-induced glycemic derangements may increase the risk of postoperative infectious complications.» The dosage and frequency of perioperative corticosteroid administration play a critical role in optimizing postoperative outcomes, with higher doses showing promise in reducing opioid consumption, postoperative pain, and length of stay.» The optimal dosage and frequency of corticosteroids remain unclear; however, the perioperative administration of 8 to 16 mg dexamethasone, or equivalent steroid, appears reasonable and safe in most cases.
GCLKT: Enhancing Exercise Interactions via Global Context Information and Graph Contrastive Learning for Knowledge Tracing
Authors: Zhang Wei , Hu Sen , Song Linngling 
Published: September 2024

Abstract

Most existing knowledge tracing models primarily utilize local context information in the sequence of learning interactions, leading to catastrophic forgetting in predicting student performance. Moreover, knowledge tracing models based on skill interactions often overlook the difficulty information of exercise, leading to the models inability to accurately assess the students' knowledge states. However, knowledge tracing models based on exercise interactions face a significant challenge of data sparsity. In order to address the aforementioned issues, we propose a novel knowledge tracing model based on global context information and graph contrastive learning (GCLKT). GCLKT first utilizes exercise interaction sequences to construct a Weighted Exercise Transition Graph (WETG), which transforms the complete sequence structure into a topological graph based on exercise-exercise relationships, providing global context information for each interaction sequence segment. Due to the sparsity of exercise data, two enhanced graphs are obtained by randomly sampling the WETG. Through maximizing the mutual information between node representations and multi-view representations in the enhanced graphs, the model learns enhanced representations of exercises to alleviate the problem of data sparsity. Finally, attention mechanisms are utilized to extract the associative relationships between exercises and skills. Moreover, a subtask is devised to model student knowledge states by predicting the difficulty of exercises as an auxiliary training objective. Experimental results on three datasets demonstrate that the proposed model not only effectively addresses the aforementioned issues but also achieves significant performance improvement compared to existing state-of-the-art baselines.
Semantic Priming effects on the Kanizsa Illusion: a case for cognitive penetrability
Authors: Mudrik Liad , Litvak Nataly Davidson , Tal Amir 
Published: September 2024

Abstract

Visual illusions are considered key examples for cognitive impenetrability, as they are held not to be affected by non-perceptual processes. We revisit this claim in five experiments (N=1148; four preregistered) focused on the Kanizsa illusion, where a nonexistent shape is experienced within illusory contours. Pac-Man-like shapes inducing the illusion were presented after primes that were either semantically related to the Pac-Man game or not. We hypothesized that semantic primes would promote interpreting the shapes as individual Pac-Man characters, thus biasing participants away from the holistic Kanizsa illusion. Indeed, we found that the Kanizsa shape was detected less when participants were primed with Pac-Man-related stimuli. We then also demonstrated the opposite effect: a prime indexing the illusory shape (‘Triangle’) enhanced the probability of seeing the illusion. Together, our results suggest that semantic priming can both reduce and increase the probability of experiencing the Kanizsa illusion, thus supporting claims of cognitive penetrability.
Incorporation of Azadirachta indica kernel in the diet of guinea pigs: Effects on digestibility and caecal health.
Authors: Tobou Gina France Djoumessi , Kenfack Laurette Blandine Mezajoug , Miégoue Emile , Fokom David Wauffo , Kuitche Herve Mubé , Dongmo Delmas Kesnel Zambou , Tendonkeng Fernand , Tchiegang Clerge , Hornick Jean Luc 
Published: September 2024

Abstract

The objective of the present study was to evaluate the effect of addition of neem (Azadirachta indica) kernel powder in diet on feed chemical components digestibility and on the composition of caecal microbiota of guinea pig. One hundred and thirty guinea pigs were divided equally into four groups. For 27 days, the animals were fed once daily a standard control diet (complete concentrate) or a concentrated mixture with 2.5, 5 or 7.5% (w/w) of neem kernel incorporation. The results showed that feed intake and digestibility increased significantly with the rate of kernel incorporation. In caeca content, the log number of lactic acid bacteria and Clostridium butyricum increased quadratically (p < 0.001) with the rate of kernel incorporation while that of Escherichia coli decreased. The results suggest that neem kernel could be used as a phytogenic supplement for guinea pigs in order to improve nutrient digestibility and microbiota quality.
Splicing Factor 3a Subunit 1 Promotes Colorectal Cancer Growth via Anti-programmed cell death of Syntaxin12.
Authors: Konishi Hiroaki , Sasaki Takahiro , Sakatani Aki , Tanaka Hiroki , Yamamoto Koji , Takahashi Keitaro , Ando Katsuyoshi , Ueno Nobuhiro , Kashima Shin , Moriichi Kentaro , Tanabe Hiroki , Okumura Toshikatsu , Fujiya Mikihiro 
Published: September 2024

Abstract

RNA dysregulation mediated by abnormal RNA binding proteins (RBPs) is associated with tumorigenesis. However, the specific tumorigenic mechanisms of each RBP remained unclear. In this study, we demonstrate that splicing factor 3A1 (SF3A1) interacts to and stabilizes the mRNA of STX12, thereby inhibiting programmed cell death (PCD) in colorectal cancer cells. Downregulation of SF3A1 significantly inhibited cell growth in colorectal cancer cells, with minimal cytotoxicity observed in non-cancerous epithelial cells. We validated the tumor-promoting function of SF3A1 in an HCT116 transplanted mouse model. TUNEL staining and western blotting of PARP revealed SF3A1 inhibits PCD in colorectal cancer cells. A transcriptome analysis, combined with RNA-immunoprecipitation (IP), demonstrated that SF3A1 interact to and stabilized 144 mRNAs. Among these mRNAs, knockdown of STX12 (Syntaxin 12) in colorectal cancer cells inhibited cell growth but had no inhibitory effect on non-cancerous epithelial cells, HCEC-1CT. The mRNA levels of STX12 were significantly reduced upon downregulation of SF3A1, contributing to the inhibition of PCD in colorectal cancer cells. Therefore, SF3A1, which mediates STX12 mRNA stabilization, represents a promising therapeutic target for the treatment of colorectal cancer with fewer side effects.
mYongHong: a structure-guided design of stable and monomeric red fluorescent protein
Authors: Fu Zhifei , Piatkevich Kiryl , Zheng Qingbing , Wu Congxian , Xiong Haiyan , Chang Qiyuan , Ding Jiayi , Wang Shuyuan , Zhang Wenhao , Li Yu , Wu Yaochen , Liu Miaoxing , Fang Guicun , Yang Yiwei , xie Jiongfang , Qi Dong , Jiang Tao , Fu Wenfeng , Hu Fen , Chen Yiming , Yue Rongcai , Li Yanbin , Cui Yong , Li Min , Fan Shilong , Yang Yufeng , Xu Yunlu , Li Dong , Zhang Fenghua , Zhao Hu 
Published: September 2024

Abstract

The stability of fluorescent proteins (FPs) is crucial for many imaging techniques, including long-term live cell imaging, correlative light and electron microscopy (CLEM), and tissue clearing. While several stable green and yellow FPs exist, the options for stable monomeric red fluorescent proteins (RFPs), commonly used as spectral counterparts for dual-color imaging, are significantly limited. Here, we applied structure-guided mutagenesis to develop an extremely stable monomeric RFP named mYongHong and report its structure at 1.5 Å resolution. Remarkably, mYongHong exhibited exceptional resistance to high temperature, chaotropic conditions, and highly oxidative environments, facilitating its efficient applications in CLEM imaging of various organelles and rapid (less than 1 day) whole organ tissue clearing. Additionally, our findings indicate that mYongHong’s thermal and chemical stability was associated with its high photostability, enabling the tracking of the fusion and fission of mitochondria using 3D structured illumination microscopy for up to 2 hours with minimal photobleaching. More importantly, the outstanding photostability made mYongHong a unique RFP for stimulated emission depletion microscopy, allowing it to capture the dynamics of the endoplasmic reticulum with a high signal-to-background ratio and strong specificity. Systematic benchmarking of mYongHong against high-performing RFPs established it as a highly stable FP suitable for multi-modality microscopy of cell cultures and model organisms (zebrafish, mice, and Nicotiana benthamiana plant), complementing existing GFPs for multiplexed imaging.
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer
Authors: Xu Tiankai , Chu Chu , Xue Shuyu , Jiang Tongchao , Wang Ying , Xia Wen , Lin Huanxin 
Published: September 2024

Abstract

Background:
Drug resistance constitutes one of the principal causes of poor prognosis in breast cancer patients. Cancer cells can survive independently of the energy provided by mitochondria; however, they are incapable of synthesizing new DNA strands without mitochondrial involvement.This may suggest that mitochondrial energy metabolism could be related to drug resistance. Hence, drug resistance and mitochondrial energy metabolism-related differentially expressed genes (DMRDEGs) may emerge as candidates for novel cancer biomarkers. This study endeavors to assess the viability of DMRDEGs as biomarkers or therapeutic targets for breast cancer.
Methods:
We utilized the DRESIS database and MSigDB to identify genes related to drug resistance. Additionally, we sourced genes associated with mitochondrial energy metabolism from GeneCards and extant literature. By merging these genes with the differentially expressed genes observed in normal and tumor tissues from the TCGA-BRCA and GEO databases, we successfully identified the DMRDEGs. Employing unsupervised consensus Clustering, we divided breast cancer patients into two distinct groups based on the DMRDEGs. Consequently, we identified four hub genes to formulate a prognostic model, applying Cox regression, LASSO regression, and Random Forest methods. Furthermore, we examined the immune infiltration and tumor mutation burden of the genes within our model and scrutinized the divergences in the immune microenvironment between high- and low-risk groups. Small hairpin RNA and lentiviral plasmids were designed for the stable transfection of breast cancer cell lines MDA-MB-231 and HCC1806. By conducting clone formation, scratch test and transwell assays, we initiated a preliminary investigation into the mechanistic roles of AIFM1.
Results:
We utilized DMRDEGs to develop a prognostic model that includes four mRNAs for breast cancer, which, by combining various clinical features and critical breast cancer facets, proved to be remarkably effective in forecasting patient outcomes. Additionally, AIFM1 appeared to enhance the proliferation, migration, and invasiveness of the breast cancer cell lines MDA-MB-231 and HCC1806.
Conclusions:
DMRDEGs have the potential to act as diagnostic markers and therapeutic targets for breast cancer. Within the mutated associated genes, ATP7B, FUS, AIFM1, and PPARG could serve as early diagnostic indicators, and notably, AIFM1 may present itself as a promising therapeutic target.
Pneumocystis sp. is a pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly
Authors: Magne Fabien , Ruiz-Ruiz Susana , Pérez-Brocal Vicente , Ponce Carolina A. , Bustamante Rebeca , Martin Viviana San , Gutierrez Mireya , Gatti Gianna , Vargas Sergio L. , Moya Andres 
Published: September 2024

Abstract

Background. Early life gut microbiota is being increasingly recognized as a major contributor to short and/or long-term human health and diseases. However, little is known about these early-life events in the human microbiome of the lower respiratory tract.
Objective. To explore fungal and bacterial colonization in the lower airways over the first year of life using lung tissue from autopsied infants.
Method. The fungal and bacterial communities of lung tissue samples from 54 autopsied infants were characterized by NGS of ITS and 16S rRNA genes respectively.
Results. Our study highlights a high degree of inter-individual variability in both fungal and bacterial communities inhabiting the infant lung, providing insights into the diverse nature of the lower respiratory tract microbiome. Mainly transient microorganisms composed the lower respiratory tract microbiota, but some genera were identified as inhabiting the lung, indicating their potential role in lung physiology or disease. At 3-4 months of age, important dynamic changes to the microbial community were observed, which might correspond to a transitional time period in the maturation of the lung microbiome. This timeframe represents a susceptibility period for the colonization of pathogens such as Pneumocystis. The asymptomatic colonization of Pneumocystis was associated with changes in the fungal and bacterial communities.
Conclusions. These findings suggest that the period of 2-4 months of age is a “critical window” early in life. Pneumocystis sp. could be a pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly, and to the future health of children.
Accounting for Temperature Influence in Non-destructive Measurements of Applied and Residual Stresses by Ultrasonic Method
Authors: Kleiman Jacob , Smilenko Volodimir , Kot Vladimir 
Published: September 2024

Abstract

Understanding the impact of temperature on ultrasonic velocity in solids is crucial for accurately assessing residual stresses (RS). A methodology and equipment, UltraMARS™, were developed for non-destructive stress measurement using ultrasound that was used successfully in measuring RS in welded structures . We studied changes in longitudinal and transverse ultrasound velocities in steel and aluminum samples across temperatures ranging from 10°C to 50°C. We incorporated a technique in the UltraMARS™ system that takes into account the effects of temperature on the measurement of uniaxial and biaxial residual stresses measured in stress-free points on the specimen. From the conducted experiments and available information in the literature, it can be suggested that the temperature does not affect the residual stress values in average through-thickness measurements.