bluuebunny/crossref_metadata_2025_split huggingface dataset:
Пролежні м’яких тканин у хворих на цукровий діабет 2-го типу: клінічні стратегії, показники інсулінорезистентності та аспекти комплексного лікування
Authors: Vergun A.R. , Krasnyi M.R. , Chulovsky Ya.B. , Vergun O.M. , Moshchynska O.M. 
Published: October 2016

Вступ. Причинами виникнення пролежневих трофічних виразок є ішемія та нейротрофічні зміни тканин, викликані їх тривалою хронічною компресією, постійним патологічним зволоженням та зсувом тканин, що детермінує виникнення локальної ішемії. Мета роботи: дослідити клінічні варіанти та гнійні ускладнення пролежнів у хворих на цукровий діабет (ЦД) 2-го типу з позицій наявності інсулінорезистентності (ІР) у контексті оптимізації комплексного лікування. Матеріали і методи. Загальну вибірку ретро- та проспективного аналізу становили результати комплексного лікування 112 пацієнтів. Наявність ЦД 2-го типу пiдтверджено в 37 пацієнтів, 27 пацієнтів iз пролежнями без ускладнень (І–ІІІ стадії) та ЦД становили І групу порівняння, iз пролежнями IV стадії — ІІ групу порівняння, інші 75 осiб — групу контролю. Результати. У хворих на ЦД 2-го типу (І група порівняння) спостерігалося вірогідно значуще зменшення НОМА-індексу функції β-клітин та збільшення НОМА-індексу ІР (8,31 ± 0,02, р < 0,01). У хворих на ЦД 2-го типу з наявністю ускладнених пролежнів (ІІ група порівняння) зареєстровано більш значне підвищення показників циркулюючого інсуліну (p2 < 0,01), НОМА-індексу ІР (p2 < 0,05) та значне зменшення НОМА-індексу функції β-клітин (р < 0,05). При проведенні кореляційного аналізу показникiв НОМА-ІР та концентрації елементів у крові кореляційний зв’язок був встановлений тільки у хворих на ЦД 2-го типу (І та ІІ групи порівняння): між показником НОМА-ІР та вмістом Mg2+ в еритроцитах виявлено негативний сильний кореляційний зв’язок (r = –0,72; Р < 0,01), між НОМА-ІР та концентрацією Zn2+ у сироватці крові — негативний зв’язок середньої сили (r = –0,66; p < 0,01) та між НОМА-ІР й рівнем Cr3+ у сироватці крові — негативний кореляційний (r = –0,69; p < 0,01). Висновки. Перевагою запропонованої класифікації пролежнів м’яких тканин та послідовності комплексного лікування є врахування особливостей патогенезу, морфогенезу та клінічного перебігу пролежнів з ускладненнями, які мають вплив на перебіг загоєння та потребують адекватних стратегій лікування гнійних ран — TIME і DOMINATE, що, на нашу думку, детермінує можливість впровадження в клінічну практику відділень паліативної допомоги, інших стаціонарних та амбулаторних закладів охорони здоров’я.
Вплив призначення вітаміну D на рівень антитіл до тиреоїдної пероксидази у хворих на гіпотиреоз автоімунного генезу
Authors: Pan’kiv I.V. 
Published: October 2016

Незважаючи на вивчення взаємозв’язків між дефіцитом і недостатністю вітаміну D з автоімунною тиреоїдною патологією, вплив додаткового призначення препаратів цього вітаміну при такій патології не з’ясований. Метою дослідження було вивчення впливу вітаміну D на вміст антитіл до тиреоїдної пероксидази (ТПО) у хворих на вперше виявлений гіпотиреоз на ґрунті автоімунного тиреоїдиту (АІТ). Матеріали та методи. Під спостереженням перебували 52 пацієнти із вперше виявленим гіпотиреозом на ґрунті АІТ, які були рандомізовані на дві групи. Хворі першої групи додатково отримували холекальциферол у дозі 2000 МО/добу (14 000 МО/тижд) і препарати кальцію в дозі 1000 мг/добу протягом 12 тижнів. Хворим другої групи було призначено на тлі левотироксину лише препарати кальцію в дозі 1000 мг/добу протягом 12 тижнів. Позитивним результатом лікування вважали зниження титру антитіл до ТПО принаймні на 25 %. Результати. У 94,2 % хворих на гіпотиреоз установлено дефіцит і недостатність вітаміну D. У хворих на гіпотиреоз відзначається вірогідна негативна кореляція між рівнем 25(ОН)D і титром антитіл до ТПО (r = –0,172; р = 0,046). Додаткове призначення вітаміну D призвело до вірогідного зниження рівня антитіл до ТПО (–48,1 %) у хворих на гіпотиреоз. Загалом зменшення рівня антитіл до ТПО на 25 % і більше досягнуто в 73,1 % хворих. Призначення препарату вітаміну D сприяло вірогідному підвищенню вмісту 25(OH)D у сироватці крові з відповідним зниженням концентрації інтактного паратгормону у хворих на гіпотиреоз на ґрунті АІТ. Висновки. Установлено позитивний вплив додаткового призначення вітаміну D на рівень антитіл до ТПО у хворих на гіпотиреоз автоімунного генезу.
Unpredictability of soft tissue changes after camouflage treatment of Class II division 1 malocclusion with maximum anterior retraction using miniscrews
Authors: Kim Kayoung , Choi Sung-Hwan , Choi Eun-Hee , Choi Yoon-Jeong , Hwang Chung-Ju , Cha Jung-Yul 
Published: October 2016

ABSTRACT
Objective: To compare soft and hard tissue responses based on the degree of maxillary incisor retraction using maximum anchorage in patients with Class II division 1 malocclusion.
Materials and Methods: This retrospective study sample was divided into moderate retraction (&lt;8.0 mm; n = 28) and maximum retraction (≥8.0 mm; n = 29) groups based on the amount of maxillary incisor retraction after extraction of the maxillary and mandibular first premolars for camouflage treatment. Pre- and posttreatment lateral cephalograms were analyzed.
Results: There were 2.3 mm and 3.0 mm of upper and lower lip retraction, respectively, in the moderate group; and 4.0 mm and 5.3 mm, respectively, in the maximum group. In the moderate group, the upper lip was most influenced by posterior movement of the cervical point of the maxillary incisor (β = 0.94). The lower lip was most influenced by posterior movement of B-point (β = 0.84) and the cervical point of the mandibular incisor (β = 0.83). Prediction was difficult in the maximum group; no variable showed a significant influence on upper lip changes. The lower lip was highly influenced by posterior movement of the cervical point of the maxillary incisor (β = 0.50), but this correlation was weak in the maximum group.
Conclusions: Posterior movement of the cervical point of the anterior teeth is necessary for increased lip retraction. However, periodic evaluation of the lip profile is needed during maximum retraction of the anterior teeth because of limitations in predicting soft tissue responses.
Effectiveness of HypoAware, a Brief Partly Web-Based Psychoeducational Intervention for Adults With Type 1 and Insulin-Treated Type 2 Diabetes and Problematic Hypoglycemia: A Cluster Randomized Controlled Trial
Authors: Rondags Stefanie M.P.A. , de Wit Maartje , Twisk Jos W. , Snoek Frank J. 
Published: October 2016

OBJECTIVETo establish the effectiveness of a brief, partly web-based group intervention, HypoAware, in patients with problematic hypoglycemia, in terms of the reduction of severe hypoglycemic episodes, impaired hypoglycemia awareness, and worries.RESEARCH DESIGN AND METHODSA two-arm, cluster randomized controlled trial was conducted in insulin-treated patients with problematic hypoglycemia in eight Dutch clinics comparing HypoAware with care as usual. Primary outcomes included self-reported severe hypoglycemia, impaired hypoglycemia awareness (Gold score), and worries and distress about hypoglycemia (Hypoglycemia Fear Survey-II/Problem Areas In Diabetes scale hypo-item), assessed at baseline, and at 2, 4, and 6 months of follow-up. We used t tests, nonparametric tests, and intention-to-treat generalized estimation equation (GEE) analyses with linear, logistic, and Poisson or negative binomial models.RESULTSWe enrolled 137 participants. Adjusted GEE analyses over four time points showed a nonsignificant 33% fewer episodes of severe hypoglycemia in the HypoAware group compared with the control group (relative risk [RR] 0.67 [95% CI 0.39–1.16], P = 0.150); a significant reduced odds of impaired awareness (odds ratio 0.38 [95% CI 0.15–0.95], P = 0.038), a trend toward 20% fewer worries about hypoglycemia (RR 0.80 [95% CI 0.64–1.01], P = 0.059), and a significant 30% less hypo-distress (RR 0.70 [95% CI 0.56–0.88], P = 0.002). Over the 6-month study duration, participants experienced a median of 2.5 events of severe hypoglycemia (interquartile range [IQR] 1–10) in the control condition versus 1 event (IQR 0–6.5) in the HypoAware group (P = 0.030). There was no significant change in HbA1c level within and between both groups.CONCLUSIONSHypoAware resulted in fewer severe hypoglycemic episodes, significantly improved hypoglycemia awareness, and less hypo-distress in comparison with usual care, and deserves further dissemination.
Effects of perioperative topical dorzolamide hydrochloride–timolol maleate administration on incidence and severity of postoperative ocular hypertension in dogs undergoing cataract extraction by phacoemulsification
Authors: Matusow Rachel B. , Herring Ian P. , Pickett J. Phillip , Henao-Guerrero Natalia , Werre Stephen R. 
Published: October 2016

Abstract
OBJECTIVE To assess the effects of topically applied 2% dorzolamide hydrochloride–0.5% timolol maleate ophthalmic solution (DHTM) on incidence and severity of postoperative ocular hypertension (POH; ie, intraocular pressure [IOP] > 25 mm Hg) in dogs undergoing cataract extraction by phacoemulsification.
DESIGN Randomized, masked, controlled study.
ANIMALS 103 dogs (180 eyes).
PROCEDURES Pertinent history, signalment, and ophthalmic examination findings were recorded. Dogs received 1 drop of DHTM or sham treatment solution (sterile, buffered, isotonic eye drops) in both eyes 14 hours and 2 hours before anesthetic induction and at the time of corneal incision closure (ie, end of surgery); IOPs were assessed by rebound tonometry 2, 4, 6, and 8 hours after surgery and between 7:30 and 8:00 am on the following day. Dogs with IOPs of 26 to 45 mm Hg received 1 drop of 0.005% latanoprost solution topically; the surgeon's treatment of choice was used for dogs with IOPs > 45 mm Hg. Incidence of POH and postoperative IOPs were compared between treatment groups.
RESULTS DHTM treatment resulted in significantly lower incidence of POH than did sham treatment at the level of the dog (18/53 [34%] vs 31/50 [62%]) and the eye (24/94 [26%] vs 42/86 [48%]). Mean IOP did not differ between groups at the time of POH detection. The DHTM-treated eyes that developed POH were significantly more likely to have a 1-hour follow-up IOP < 25 mm Hg after latanoprost administration than were sham-treated eyes (19/25 [76%] vs 18/35 [51%]; OR, 3.87).
CONCLUSIONS AND CLINICAL RELEVANCE Multidose perioperative administration of DHTM in dogs undergoing phacoemulsification reduced the incidence of POH and improved responsiveness of POH to latanoprost treatment.
Primary nodal hemangiosarcoma in four dogs
Authors: Chan Catherine M. , Zwahlen Courtney H. , de Lorimier Louis-Philippe , Yeomans Stephen M. , Hoffmann Karon L. , Moore Antony S. 
Published: October 2016

Abstract
CASE DESCRIPTION 4 dogs with a slow-growing mass in the cervical region were evaluated.
CLINICAL FINDINGS All dogs had no clinical signs at the time of the evaluation. There was no apparent evidence of visceral metastases or other primary tumor based on available CT or MRI data for any dog.
TREATMENT AND OUTCOME For each dog, surgery to remove the mass was performed. Histologic examination of the excised tissue revealed a completely excised grade 1 or 2 lymph node hemangiosarcoma. All dogs received adjuvant chemotherapy; 2 dogs underwent curative intent chemotherapy, 1 dog underwent metronomic treatment with cyclophosphamide, and 1 dog underwent metronomic treatment with chlorambucil. The survival time was 259 days in 1 dog; 3 dogs were still alive 615, 399, and 365 days after surgery.
CLINICAL RELEVANCE Primary nodal hemangiosarcoma in dogs is a rare and, to the authors' knowledge, previously undescribed disease that appears to develop in the cervical lymph nodes as a slow-growing mass or masses. Surgical excision and adjunct treatment resulted in long survival times for 3 of the 4 dogs of the present report. Given the aggressive biologic behavior of hemangiosarcomas in other body locations, adjunct chemotherapy should be considered for affected dogs, although its role in the cases described in this report was unclear. Additional clinical information is required to further characterize the biologic behavior of this tumor type and determine the expected survival times and associated risk factors in dogs.
Ten-year survival of Ugandan infants after myelomeningocele closure
Authors: Sims-Williams Helen J. , Sims-Williams Hugh P. , Kabachelor Edith Mbabazi , Fotheringham James , Warf Benjamin C. 
Published: October 2016

OBJECTIVE
Myelomeningocele (MM) is a neural tube defect complicated by neurological deficits below the level of the spinal lesion and, in many cases, hydrocephalus. Long-term survival of infants treated for MM in a low- and middle-income country has never been reported. This retrospective cohort study reports 10-year outcomes and factors affecting survival for infants undergoing MM repair at CURE Children's Hospital of Uganda.

METHODS
Patients were traced by telephone or home visit. Survival was estimated using the Kaplan-Meier method. Multivariate survival was analyzed using the Cox proportional hazards model, investigating the following variables: sex, age at surgery, weight-for-age at surgery, motor level, and presence and management of hydrocephalus.

RESULTS
A total of 145 children underwent MM repair between 2000 and 2004; complete data were available for 133 patients. The probability of 10-year survival was 55%, with 78% of deaths occurring in the first 5 years. Most of the deaths were not directly related to MM; infection and neglect were most commonly described. Lesions at motor level L-2 or above were associated with increased mortality (HR 3.176, 95% CI 1.557–6.476). Compared with repair within 48 hours of birth, surgery at 15–29 days was associated with increased mortality (HR 9.091, 95% CI 1.169–70.698).

CONCLUSIONS
Infants in low- and middle-income countries with MM can have long-term survival with basic surgical intervention. Motor level and age at surgery were significant factors influencing outcome. Education of local health care workers and families to ensure both urgent referral for initial treatment and subsequent access to basic medical care are essential to survival.
Stage dependent nutritional regulation of transgenerational longevity
Authors: Roussou Ilianna G. , Savakis Charalambos , Tavernarakis Nektarios , Metaxakis Athanasios 
Published: October 2016

BACKGROUND: Statistical analyses in human populations have associated limited food availability during development with increased longevity of next generations. In support, recent findings in Caenorhabditis elegans revealed nutritional effects on transgenerational longevity. OBJECTIVES: In this study we tested the effect of nutrition on longevity of future generations in Drosophila and whether this is sex-specific. METHODS: We reared male larvae and adults of Drosophila under different food conditions and performed lifespan analyses in F2 generation. RESULTS: Grandsons of males which experienced starvation through larval stages were long-lived and grandsons of well fed larvae were short lived, in two Drosophila strains. In one strain, the nutritional effect on transgenerational longevity was transmitted through male line. Interestingly, we find that dietary restriction in adult males is the main nutritional condition affecting lifespan of grandsons. CONCLUSIONS: Our findings suggest that nutritional regulation of transgenerational longevity is evolutionarily conserved and developmental stage – dependent in Drosophila.
High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials
Authors: Neshatdoust Sara , Saunders Caroline , Castle Sophie M. , Vauzour David , Williams Claire , Butler Laurie , Lovegrove Julie A. , Spencer Jeremy P. E. 
Published: October 2016

BACKGROUND: Recent clinical studies have indicated the beneficial impact of dietary flavonoid intake on human cognitive performance. Although the mechanisms that mediate such improvements are currently unclear, animal and human trial data suggest that changes in neurotrophin expression, and related signalling apparatus, may be involved. OBJECTIVE: To investigate the link between changes in serum brain-derived neurotrophic factor (BDNF) and changes in human cognitive performance following flavonoid intake. METHODS: The relationship between serum levels of BDNF and age, gender, BMI, waist circumference, blood pressure and cognition at baseline, and following flavonoid intake, was investigated in two distinct randomised, controlled clinical trials. Trial 1 was conducted in men and women (aged 26–70 y; consuming an average of 3 portions of fruit and vegetables per day) and delivered high-flavonoid (>15 mg/100 g) or low-flavonoid (<5 mg/100 g) fruit and vegetables and increased intake by 2 portions every 6 weeks. The control arm was habitual diet over the same time frame. Trial 2 was conducted in an older males and female cohort (aged 62–75 y) intervening with a high-flavanol cocoa drink (494 mg total flavanols) and a low-flavanol cocoa drink (23 mg total flavanols) for 12 weeks. RESULTS: Serum BDNF levels increased linearly to the age of 65, after which BDNF levels were found to decrease markedly. All other physiological and anthropometric measurements proved to not be significantly associated with serum BDNF levels ( p > 0.05), although higher levels in males compared to females almost achieved significance ( p = 0.056). At baseline, higher serum BDNF levels were associated with significantly better global cognition scores, relative to individuals with lower serum levels. In addition, following intervention for 18 weeks, high-flavonoid, but not low-flavonoid, fruit and vegetable intake induced significant improvements in cognitive performance and increases in serum BDNF levels ( p = <0.001). Flavanol intervention for 12 weeks also resulted in significant increases in serum BDNF ( p = <0.001), and such increases were correlated with improvements in global cognitive performance. CONCLUSION: Increases in global cognition induced by high flavonoid fruit and vegetables, and cocoa flavanols were paralleled by concurrent changes in serum BDNF levels, suggesting a role for BDNF in flavonoid-induced cognitive improvements. Furthermore, we provide further data suggesting that serum BDNF levels may represent a biomarker of cognitive function.
Mutations in two pollen self‐incompatibility factors in geographically marginal populations of Solanum habrochaites impact mating system transitions and reproductive isolation
Authors: Markova Dragomira N. , Petersen Jennifer J. , Qin Xiaoqiong , Short Daniel R. , Valle Matthew J. , Tovar‐Méndez Alejandro , McClure Bruce A. , Chetelat Roger T. 
Published: October 2016

PREMISE OF THE STUDY:Self‐incompatibility (SI) is a mechanism that prevents inbreeding in many plant species. The mutational breakdown of SI occurs frequently, yet relatively little is known about the evolutionary steps involved in the progressive loss of pistil and pollen SI function.METHODS:In Solanaceae, SI is the S‐RNase‐based gametophytic type. We used SI and SC populations of the wild tomato species Solanum habrochaites to study natural variation for two pollen SI factors: a Cullin1 (CUL1) protein and an S‐locus F‐box protein (SLF‐23). Pollen compatibility was assessed on an allotriploid tester line encoding an S‐RNase recognized by SLF‐23. Both pollen factors are required for compatibility on this tester line. Complementation tests and gene sequencing were used to identify mutations in CUL1 or SLF‐23.KEY RESULTS:We detected loss‐of‐function mutations in CUL1 and/or SLF‐23 in SC populations collected near the northern and southern geographic margins of this taxon's natural range. Nonmarginal SC and all SI accessions expressed mostly functional alleles of these pollen factors. Comparison of the CUL1 sequences identified several shared deletion mutations present in both northern and southern margin SC accessions.CONCLUSIONS:Loss‐of‐function mutations in CUL1 and SLF‐23 likely became fixed relatively late during SI to SC transitions, after loss of pistil SI function. Mutations in CUL1 establish unilateral incompatibility with SI populations and strengthen reproductive isolation. Point mutations common to northern and southern SC biotypes likely derive from shared ancestral variants found in more central SI populations.
HIGH-ENERGY NEUTRINOS FROM RECENT BLAZAR FLARES
Authors: Halzen Francis , Kheirandish Ali 
Published: October 2016

ABSTRACT
The energy density of cosmic neutrinos measured by IceCube matches the one observed by Fermi in extragalactic photons that predominantly originate in blazars. This has inspired attempts to match Fermi sources with IceCube neutrinos. A spatial association combined with a coincidence in time with a flaring source may represent a smoking gun for the origin of the IceCube flux. In 2015 June, the Fermi Large Area Telescope observed an intense flare from blazar 3C 279 that exceeded the steady flux of the source by a factor of 40 for the duration of a day. We show that IceCube is likely to observe neutrinos, if indeed hadronic in origin, in data that are still blinded at this time. We also discuss other opportunities for coincident observations that include a recent flare from blazar 1ES 1959+650 that previously produced an intriguing coincidence with AMANDA observations.
TIDAL RESPONSE OF PRELIMINARY JUPITER MODEL
Authors: Wahl Sean M. , Hubbard William B. , Militzer Burkhard 
Published: October 2016

ABSTRACT
In anticipation of improved observational data for Jupiter’s gravitational field, from the Juno spacecraft, we predict the static tidal response for a variety of Jupiter interior models based on ab initio computer simulations of hydrogen–helium mixtures. We calculate hydrostatic-equilibrium gravity terms, using the non-perturbative concentric Maclaurin Spheroid method that eliminates lengthy expansions used in the theory of figures. Our method captures terms arising from the coupled tidal and rotational perturbations, which we find to be important for a rapidly rotating planet like Jupiter. Our predicted static tidal Love number,

, is ∼10% larger than previous estimates. The value is, as expected, highly correlated with the zonal harmonic coefficient J
2, and is thus nearly constant when plausible changes are made to the interior structure while holding J
2 fixed at the observed value. We note that the predicted static k
2 might change, due to Jupiter’s dynamical response to the Galilean moons, and find reasons to argue that the change may be detectable—although we do not present here a theory of dynamical tides for highly oblate Jovian planets. An accurate model of Jupiter’s tidal response will be essential for interpreting Juno observations and identifying tidal signals from effects of other interior dynamics of Jupiter’s gravitational field.
Oxygen-ozone therapy in the treatment of adipose tissue diseases
Authors: Cuccio Gaetano , Franzini Marianno 
Published: October 2016

The panniculosis or edematous fibrosclerotic panniculopathy (PEFS), commonly called <em>cellulite</em> is a subcutaneous adipose disease that afflicts the vast majority of women at all ages. PEFS is framed as a subcutaneous adipose suffering from venous and lymphatic stasis whose etiology is multifactorial. Many others are the implications and clinical relapses of diseases of inflammatory or autoimmune basis that determine disease states with involvement of the patient’s general conditions. The oxygen-ozone therapy, thanks to its abilities of improving the rheological properties of the microcirculation, immuno-modulating and anti-inflammatory abnormalities, arises as adjuvant and is a valid method, which is also an alternative compared to conventional protocols.