bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spatial composition of porcine adipose tissue investigated by multivariate curve resolution of near infrared spectra: Relationships between fat, the degree of unsaturation and water
Authors: Sørensen Klavs Martin , Engelsen Søren Balling 
Published: December 2017

This study represents a continuation of a previously performed study by Sørensen, et al. (2012) about the use of and development of an online method for determining the iodine number in porcine adipose tissue by the use of near infrared spectroscopy. In the original study, the fat tissue was measured as a function of the depth from the skin and thus represent spatial or 2D near infrared data, and if measured across a porcine carcass it represents 3D data of the pig. These data structures, which were largely ignored in the original publication, are here explored by multivariate curve resolution. The massive amount of near infrared data (11,329 spectra) was unfolded from the true five-way array (carcass × horizontal position × vertical position × depth × spectral data points, 30 × 6 × 15 × 6 × 204) into a two-way matrix (sample × spectra, 11329 × 204) (maintaining spatial data in a separate array) and multivariate curve resolution applied. A two-component multivariate curve resolution model proved to fit the data nearly perfectly (99.69% X variance explained). By concentration the highest component was found to be fat, and the second component was found to be water. Surprisingly, the latter was found to co-vary strongly with the iodine value of the fat ( r = −0.83). The resulting multivariate curve resolution model was folded back into its original spatial dimension to produce maps showing distribution of the constituent concentrations in the adipose tissue.
Including Language Access into Medicaid ACO Design
Authors: Gershon Rachel , Morris Lisa , Ferguson Warren 
Published: December 2017

Quality health care relies upon communication in a patient's preferred language. Language access in health care occurs when individuals are: (1) Welcomed by providers regardless of language ability; and (2) Offered quality language services as part of their care. Federal law generally requires access to health care and quality language services for deaf and Limited English Proficient (LEP) patients in health care settings, but these patients still find it hard to access health care and quality language services.Meanwhile, several states are implementing Medicaid Accountable Care Organization (ACO) initiatives to reduce health care costs and improve health care quality. Alternative payment methods used in these initiatives can give Accountable Care Organizations more flexibility to design linguistically accessible care, but they can also put ACOs at increased financial risk for the cost of care. If these new payment methods do not account for differences in patient language needs, ACO initiatives could have the unintended consequence of rewarding ACOs who do not reach out to deaf and LEP communities or offer quality language services.We reviewed public documents related to Medicaid ACO initiatives in six states. Some of these documents address language access. More could be done, however, to pay for language access efforts. This article describes Medicaid ACO initiatives and explores how different payment tools could be leveraged to reward ACOs for increased access to care and quality language services. We find that a combination of payment tools might be helpful to encourage both access and quality.
A Study to Elicit Behavioral Health Patients' and Providers' Opinions on Health Records Consent
Authors: Grando Maria Adela , Murcko Anita , Mahankali Srividya , Saks Michael , Zent Michael , Chern Darwyn , Dye Christy , Sharp Richard , Young Laura , Davis Patricia , Hiestand Megan , Hassanzadeh Neda 
Published: December 2017

A main objective of this study is to assess the opinions of 50 behavioral health patients on selective control over their behavioral and physical health information. We explored patients' preferences regarding current consent models, what health information should be shared for care and research and whether these preferences vary based on the sensitivity of health information and/or the type of provider involved. The other objective of this study was to solicit opinions of 8 behavioral health providers on patient-driven granular control of health information and potential impact on care.Electronic surveys were implemented at an outpatient Behavioral Health facility that provides care for behavioral health patients with non-serious mental illnesses. The Patient Survey included questions regarding patients' demographics and about their concerns and preferences for data sharing for care and research. The Provider Survey included questions about their view on the current consent process and perceptions on barriers and facilitators to implement patient-controlled granular consent models.This novel study provides valuable preliminary data that can help guide future studies to better understand privacy choices of this underrepresented patient group.
Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng)
Authors: Zhang Jian-Gang , Geng Chang-An , Huang Xiao-Yan , Chen Xing-Long , Ma Yun-Bao , Zhang Xue-Mei , Chen Ji-Jun 
Published: December 2017

Uncaria rhynchophylla (Gou-Teng in Chinese) is officially documented in Chinese pharmacopoeia as one of the authentic sources for the crude drug of Gou-Teng which has long been used for mental and cardiovascular diseases. Indole alkaloids are the characteristic constituents responsible for the desired hypotensive effect; however, the psychiatric active constituents of Gou-Teng are still unclear. According to traditional Chinese medicine theory, only the hook-bearing stems of U. rhynchophylla are used as the crude materials for Gou-Teng, while its leaves and fruits are scarcely used. The present study aimed to compare the metabolic fingerprints of different parts (hooks, stems, leaves and fruits) of U. rhynchophylla by LC-DAD-MS/MS analysis and further evaluate their psychiatric activities on HEK293 cell line in vitro. A total of 38 constituents including 26 alkaloids, six flavonoids, two triterpenoids, two chlorogenic acid analogs and two other compounds were characterized. The different parts of U. rhynchophylla can be well differentiated from their chemical profiles. Leaves displayed the most potent activity on both MT1 and MT2 receptors, with agonistic rates of 39.7% and 97.6%. For 5-HT1A and 5-HT2C receptors, hooks showed the strongest activity with agonistic rates of 92.6% and 83.1%, respectively. This investigation provided valuable information for understanding the chemical divergence between different parts of U. rhynchophylla, and their substantial bases for psychiatric purposes.
Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma
Authors: Horwitz Steven M. , Koch Raphael , Porcu Pierluigi , Oki Yasuhiro , Moskowitz Alison , Perez Megan , Myskowski Patricia , Officer Adam , Jaffe Jacob D. , Morrow Sara N. , Allen Kerstin , Douglas Mark , Stern Howard , Sweeney Jennifer , Kelly Patrick , Kelly Virginia , Aster Jon C. , Weaver David , Foss Francine M. , Weinstock David M. 
Published: December 2017

Key PointsThe oral PI3K-δ,γ inhibitor duvelisib demonstrated clinical activity and a favorable safety profile in patients with CTCL and PTCL. Duvelisib induced cell-autonomous killing of TCL lines and reprogrammed PTCL-associated macrophages in vivo.
Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections
Authors: Hetzel Miriam , Mucci Adele , Blank Patrick , Nguyen Ariane Hai Ha , Schiller Jan , Halle Olga , Kühnel Mark-Philipp , Billig Sandra , Meineke Robert , Brand Daniel , Herder Vanessa , Baumgärtner Wolfgang , Bange Franz-Christoph , Goethe Ralph , Jonigk Danny , Förster Reinhold , Gentner Bernhard , Casanova Jean-Laurent , Bustamante Jacinta , Schambach Axel , Kalinke Ulrich , Lachmann Nico 
Published: December 2017

Key PointsHematopoietic cell and gene therapy can prevent in vivo infections by Mycobacteria spp. using different lentiviral vectors. Cellular repair of macrophages in vivo highlights phagocytes as key players in the disease progression.
Dose Dependency and a Functional Cutoff for TPO-Antibody Positivity During Pregnancy
Authors: Korevaar Tim I M , Pop Victor J , Chaker Layal , Goddijn Mariette , de Rijke Yolanda B , Bisschop Peter H , Broeren Maarten A , Jaddoe Vincent W V , Medici Marco , Visser Theo J , Steegers Eric A P , Vrijkotte Tanja G , Peeters Robin P 
Published: December 2017

Abstract

Objective
To investigate a dose dependency of thyroperoxidase antibody (TPOAb) concentrations in relation to thyroid function and premature delivery and define a population-based, pregnancy-specific, functional cutoff for TPOAb positivity.

Design
Individual participant meta-analysis of three prospective birth cohorts: the Amsterdam Born Children and their Development study, and the Holistic Approach to Pregnancy.

Setting
Population-based studies in the Netherlands (2002 to 2014).

Participants
A total of 11,212 pregnant women (&lt;20 weeks’ gestation).

Main Outcome Measures
Thyrotropin (TSH) and FT4 concentrations, premature delivery.

Results
In all cohorts, there was a dose-dependent positive association of TPOAb concentrations with TSH concentrations, as well as a dose-dependent negative association with FT4 concentrations during early pregnancy (all P &lt; 0.0001). There was a dose-dependent association of TPOAb concentrations with the risk of premature delivery, which was also modified by TSH concentrations. Women with TPOAb concentrations from the 92nd percentile upward had a higher TSH and a higher risk of a TSH &gt;2.5 mU/L (range, 19.4% to 51.3%). Stratified analyses showed that women with TPOAb concentrations below manufacturer cutoffs already had a higher risk of premature delivery, especially when TSH concentrations were high or in the high-normal range.

Conclusions
This study demonstrated a dose-dependent relationship between TPOAbs and thyroid function as well as the risk of premature delivery. Furthermore, our results indicate that the currently used cutoffs for TPOAb positivity may be too high. Furthermore, the use of a population-based cutoff for TPOAbs may identify women with a clinically relevant extent of thyroid autoimmunity and a higher risk of premature delivery but that would not be considered TPOAb positive or eligible for treatment otherwise.
Who Should Finance the Supply Chain? Impact of Credit Ratings on Supply Chain Decisions
Authors: Kouvelis Panos , Zhao Wenhui 
Published: December 2017

Problem description: We study the impact of credit ratings on operational and financial decisions of a supply chain with a supplier and a retailer interacting via an early payment discount contract. The retailer has a single opportunity to order a product from the supplier to satisfy future uncertain demand. Both the retailer and supplier are capital constrained, and the retailer can use both short-term bank loans and trade credits for his financing needs, while the supplier can use short-term bank loans and/or the retailers early payment. We analyze for all relevant operational decisions (wholesale price, trade credit rates, bank loans, and order quantity) for capital-constrained firms. Academic/practical relevance: We add a framework on who should finance inventories, and at what rates, in the presence of differential credit ratings of the supply chain parties. Methodology: Within a modified selling to the newsvendor Stackelberg game with the supplier as the leader, we derive the equilibrium trade credit rates, wholesale price, bank loans, and order quantity. Results: We show there exists a threshold such that if the supplier’s credit rating is above it, then the supplier offers trade credits with zero interest rate and the retailer uses trade credits only. Otherwise, the supplier sets a positive rate, which motivates the retailer to combine trade credits and bank loans. The supplier always benefits from working with good rating retailers. A retailer prefers to work with suppliers outside the supplier’s credit rating hole (a finite set of ratings) over suppliers with ratings within the range. Managerial implications: We provide insights on who should finance supply chain inventories and at what rates when there are differential credit rating between the supplier and retailer. We provide a plausible explanation for the practice of large and good credit rating retailers maintaining a small cash ratio and working with small suppliers in developing countries. The online appendix is available at https://doi.org/10.1287/msom.2017.0669 . This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Interface of Finance, Operations, and Risk Management.
Shifting gender gaps in journalism? A longitudinal study on gender segregation in a converging media environment
Authors: De Vuyst Sara 
Published: December 2017

Abstract
This study explores whether recent technological changes in journalism have confirmed traditional gender segregation or created new gender divides. Our first research question focuses on the representation of male and female journalists in online and cross-media journalism that has emerged in the increasingly converged media landscape. Our second question looks at digital tools and explores whether social media are used differently by male and female journalists. In five-year intervals, we conducted a longitudinal survey (2003, 2008, 2013) in which all active journalists in the Dutch-speaking part of Belgium were invited to participate. The response rate was 45% in 2003 (1026 journalists), 31% in 2008 (682 journalists) and 33% in 2013 (751 journalists). Our findings show that women are underrepresented in online and cross-media journalism: female journalists work for fewer websites compared to male journalists and produce less content for different media sectors. The traditional forms of gender segregation were reflected in online journalism. Female journalists also used fewer microblogs, such as Twitter, to disseminate information.
How to be a choni: Tutorial videos, class and gender in Spain’s economic recession
Authors: Moreno Segarra Ignacio , Bernárdez Rodal Asunción 
Published: December 2017

Abstract
This article examines the construction of the choni (chavette) character through ironic and popular beauty tutorials created by Spanish vloggers and their connection with the economic recession in Spain. Our main objective is to discover the use of gender, cultural and class markers in this process and their relation to the dynamics of self-construction and self-differentiation existent on YouTube. In order to identify these characteristics, we are going to use a semiotic and Foucauldian discourse analysis based on the cultural approach to the chav phenomenon in the United Kingdom. The findings from our research illustrate how the figure of the choni is defined by the process of racialization and sexualization and by a lack of cultural competence.
Training Methods and Considerations for Practitioners to Reduce Interlimb Asymmetries
Authors: Bishop Chris , Turner Anthony , Read Paul 
Published: December 2017

ABSTRACT
INTERLIMB ASYMMETRIES HAVE BEEN A COMMON SOURCE OF INVESTIGATION IN RECENT YEARS WITH MOST STUDIES HIGHLIGHTING ITS PREVALENCE IN A RANGE OF ATHLETIC TASKS. FEW HAVE TESTED WHETHER REDUCING INTERLIMB DIFFERENCES IS REQUIRED FOR IMPROVED PHYSICAL PERFORMANCE. FURTHERMORE, THERE ARE A NUMBER OF CONSIDERATIONS THAT MAY EXIST, WHICH PRACTITIONERS SHOULD CONSIDER BEFORE STARTING TRAINING INTERVENTIONS TO REDUCE THESE DIFFERENCES. THIS ARTICLE WILL DISCUSS THE AVAILABLE BODY OF LITERATURE PERTAINING TO THE REDUCTION OF INTERLIMB ASYMMETRIES TO DATE AND PROVIDE EXAMPLES OF TRAINING PROGRAMS TO SHOW HOW THEY CAN BE ADDRESSED IF THEIR REDUCTION IS DEEMED NECESSARY.
Bearing Steel Technologies: 11th Volume, Advances in Steel Technologies for Rolling Bearings
Authors: Beswick John M. 
Published: December 2017

Description
Get 28 peer-reviewed papers on the latest advancements in rolling bearing steel technologies.
This book features extensive research from the world’s leading bearing steel technology practitioners, including steelmakers, semi-finished and finished bearing steel component producers, rolling bearing producers, development institutes, and academics.
Topics include
These papers were presented at a November 2016 symposium sponsored by ASTM International Committee A01 on Steel, Stainless Steel, and Related Alloys.
Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans
Authors: Fu Ci , Donadio Nicholas , Cardenas Maria E , Heitman Joseph 
Published: December 2017

Abstract
The Ca2+/calmodulin-dependent protein phosphatase calcineurin orchestrates sexual reproduction, stress responses, and virulence via branched downstream pathways in the opportunistic human fungal pathogen Cryptococcus neoformans. The calcineurin-binding protein Cbp1, the calcineurin temperature suppressor Cts1, the calcineurin-responsive zinc finger transcription factor Crz1, and the calcineurin targets Pbp1, Tif3, and Puf4, all function downstream of calcineurin to orchestrate distinct cellular processes. To elucidate how the calcineurin pathway regulatory network governs unisexual reproduction, stress responses, and virulence, we have analyzed the self-filamentous C. deneoformans strain, XL280α, and generated double mutants of these calcineurin downstream genes. We demonstrated that calcineurin governs unisexual reproduction at different sexual developmental stages, in which the initiation of the yeast–hyphal morphological transition is independent of Crz1, whereas the sporulation process is dependent on Crz1. Calcineurin-dependent unisexual reproduction is independent of the pheromone response pathway. Crz1 synergistically interacts with different calcineurin downstream targets in responding to ER, high-calcium, and cell wall stresses. We observed a widespread synergy suggesting that these proteins function in complex branched pathways downstream of calcineurin with some functional redundancy, which may allow efficient signaling network rewiring within the pathway for prompt adaptation to changing environments. Finally, we showed that deletion of PBP1 or TIF3 in the cna1∆ mutant background conferred a modest level of growth tolerance at 37°, but that the cna1∆ pbp1∆ and cna1∆ tif3∆ double mutants were both avirulent, suggesting that calcineurin may control virulence via mechanisms beyond thermotolerance.
A Distally Based Sartorius Muscle Flap for a Gustilo Grade-III Open Fracture of the Lateral Femoral Condyle and the Head of the Fibula with a Complex Soft-Tissue Defect
Authors: Bouveau Victoire , Potage Damien , Dubory Arnaud , Chevallier Romain , Meningaud Jean-Paul , Niddam Jérémy , Flouzat-Lachaniette Charles-Henri 
Published: December 2017

Case:
We present a case of lower-limb trauma associated with an extensive soft-tissue defect around the knee joint, which led to the exposure of bone and the metalwork that was used for the management of the associated fractures. Coverage was performed with a distally based sartorius muscle flap in a single-stage procedure, allowing good recovery with a nice aesthetic and functional outcome at the 1-year follow-up. Additionally, we discuss alternative options for the coverage of severe soft-tissue defects based on the clinical context.

Conclusion:
A distally based sartorius muscle flap may be a suitable alternative for coverage of complex soft-tissue defects around the knee joint.
Microemulsion Phase-Behavior Equation-of-State Model Using Empirical Trends in Chemical Potentials
Authors: Torrealba V. A. , Johns R. T. 
Published: December 2017

SummarySurfactant-based enhanced oil recovery (EOR) is a promising technique because of surfactant's ability to mobilize previously trapped oil by significantly reducing capillary forces at the pore scale. However, the field-implementation of these techniques is challenged by the high cost of chemicals, which makes the margin of error for the deployment of such methods increasingly narrow. Some commonly recognized issues are surfactant adsorption, surfactant partitioning to the excess phases, thermal and physical degradation, and scale-representative phase behavior.Recent contributions to the petroleum-engineering literature have used the hydrophilic/lipophilic-difference net-average-curvature (HLD-NAC) model to develop a phase-behavior equation of state (EoS) to fit experimental data and predict phase behavior away from tuned data. The model currently assumes spherical micelles and constant three-phase correlation length, which may yield errors in the bicontinuous region where micelles transition into cylindrical and planar shapes.In this paper, we introduce a new empirical phase-behavior model that is based on chemical-potential (CP) trends and HLD that eliminates NAC so that spherical micelles and the constant three-phase correlation length are no longer assumed. The model is able to describe all two-phase regions, and is shown to represent accurately experimental data at fixed composition and changing HLD (e.g., a salinity scan) as well as variable-composition data at fixed HLD. Further, the model is extended to account for surfactant partitioning into the excess phases. The model is benchmarked against experimental data (considering both pure-alkane and crude-oil cases), showing excellent fits and predictions for a wide variety of experiments, and is compared to the recently developed HLD-NAC EoS model for reference.
Hydrochemistry and water quality assessment of the Maroon River in Behbahan area, SW Iran
Authors: Ehya Farhad , Moghadam Zeynab Firouzeh 
Published: December 2017

Abstract
Assessing water quality is important in optimizing water usage. In this study, six water samples were taken from points along the Maroon River in order to evaluate its quality. The concentrations of Cl−, SO42−, HCO3−, CO32−, NO3−, K+, Mg2+, Na+, and Ca2+, as well as pH, electrical conductivity (EC) and total dissolved solids (TDS) were measured. The results were compared with the WHO (World Health Organization) drinking water guidelines and the FAO (Food and Agricultural Organization of United Nations) standard for irrigation water. The values of EC, TDS, Ca2+, Cl− and SO42− in two samples, and that of Mg2+ in one sample from downstream exceed WHO recommended limits. The K+, Na+ and NO3− concentrations are below the WHO limits. The dominant water facies is bicarbonate-calcium (HCO3-Ca). A Schoeller diagram shows that the water samples are of ‘Good’ and ‘Intermediate’ classes, while a Wilcox diagram reveals that the water is in classes C2S1, C3S3 and C3S2 – i.e., ‘Good’ or ‘Intermediate’ – for agricultural purposes. The water quality indices %Na, sodium adsorption ratio (SAR), residual sodium carbonate (RSC), permeability index (PI), magnesium adsorption ratio (MAR) and Kelly's ratio (KR), also indicate that the water is suitable for irrigation. In terms of EC, the water samples are of ‘Good’ and ‘Permissible’ quality. Geochemical investigations show that the water chemistry is influenced by evaporation, dissolution of evaporitic minerals, ion exchange and human activities.