bluuebunny/crossref_metadata_2025_split huggingface dataset:
LA OTRA CARA. Políticas públicas, inclusión laboral y jóvenes urbanos de sectores populares en un movimiento social
Authors: Otero Analia Elizabeth 
Published: October 2016

El propósito del artículo es reflexionar sobre las políticas públicas implementadas desde el gobierno nacional hacia los movimientos sociales en el contexto argentino actual. El interés es debatir la influencia de los programas sociales –en particular el Programa de Ingreso Social con Trabajo (en adelante PAT)– en la situación de los jóvenes de sectores urbanos populares. Lo haremos a partir de abordar la compleja relación entre los emprendimientos cooperativos, las políticas de subsidio y las estrategias de los jóvenes participantes en una experiencia territorial. La base empírica resulta de una investigación cualitativa con militantes de un movimiento de trabajadores desocupados. Los hallazgos dan cuenta de múltiples tensiones; mientras que su adscripción a la acción colectiva promueve la autogestión y mediatiza el acceso a planes sociales, como componentes de la fuerza de trabajo en período activo y de formación, los trabajadores desocupados siguen ubicados en posiciones marginales respecto al mercado de empleo. The purpose of this article is to reflect on the public policies implemented from the national government to the social movements in Argentina’s current context. The interest is to discuss the influence of social programs, including Social Program Income through Work (hereafter pat) in the situation of young people from urban areas. We will address it from the complex relationship established among cooperative ventures, social policies and strategies of the young participants in a territorial experience. The empirical basis is a qualitative research with a militant movement of unemployed workers. The findings realize multiple stresses; while its allegiance to collective action promotes self–management and mediates access to social programs as components of the active labor force and training period, which are located in marginal positions on the labor market.
Debilidades dentro de los procesos de mundialización textil y relación con la rse a través de un analisis delphi: ética o estética
Authors: Luque González Arturo , Hernández Zubizarreta Juan , De Pablos Heredero Carmen 
Published: October 2016

The objective of this research is to identify the main weaknesses of corporate social responsibility in the textile sector and to propose procedures that help to overcome them. We start from the assumption that the asymmetries and necessary relationships generated to manufacture textile garments in the international context are not attributable to a single circumstance. Equally, it is reasonable to assume that the solutions to these asymmetries are affected by the identification and transversality of such circumstances. The present research was carried out by gathering the opinions and solutions of participants in a Delphi analysis to uncover the critical points and vulnerabilities of the sector. The weaknesses of the sector were then identified following the analysis of responses from two expert panels to two multidisciplinary questionnaires, the questions for which were developed from the stated hypotheses.El objetivo de esta investigación es detectar las principales debilidades del sector textil en relación con la responsabilidad social empresarial y proponer medidas que contribuyan a superarlas. Partimos de que las asimetrías y relaciones generadas necesarias para fabricar prendas textiles en el contexto internacional no son imputables a una sola circunstancia. Es igualmente entendible que sus soluciones pasen por la identificación y la transversalidad de dichas circunstancias. En la presente investigación, lo llevamos a cabo mediante la de la recolección de opiniones y soluciones expresadas por diferentes participantes, y a través de un análisis Delphi, para conocer cuáles son los puntos críticos y vulnerabilidades del sector, y la posterior identificación de sus debilidades tras el análisis de las respuestas de dos paneles de expertos a dos cuestionarios multidisciplinares con preguntas desarrolladas sobre las hipótesis planteadas.
Transcriptome response to elevated atmospheric CO2concentration in the Formosan subterranean termite,Coptotermes formosanusShiraki (Isoptera: Rhinotermitidae)
Authors: Wu Wenjing , Li Zhiqiang , Zhang Shijun , Ke Yunling , Hou Yahui 
Published: October 2016

BackgroundCarbon dioxide (CO2) is a pervasive chemical stimulus that plays a critical role in insect life, eliciting behavioral and physiological responses across different species. High CO2concentration is a major feature of termite nests, which may be used as a cue for locating their nests. Termites also survive under an elevated CO2concentration. However, the mechanism by which elevated CO2concentration influences gene expression in termites is poorly understood.MethodsTo gain a better understanding of the molecular basis involved in the adaptation to CO2concentration, a transcriptome ofCoptotermes formosanusShiraki was constructed to assemble the reference genes, followed by comparative transcriptomic analyses across different CO2concentration (0.04%, 0.4%, 4% and 40%) treatments.Results(1) Based on a high throughput sequencing platform, we obtained approximately 20 GB of clean data and revealed 189,421 unigenes, with a mean length and an N50 length of 629 bp and 974 bp, respectively. (2) The transcriptomic response ofC. formosanusto elevated CO2levels presented discontinuous changes. Comparative analysis of the transcriptomes revealed 2,936 genes regulated among 0.04%, 0.4%, 4% and 40% CO2concentration treatments, 909 genes derived from termites and 2,027 from gut symbionts. Genes derived from termites appears selectively activated under 4% CO2level. In 40% CO2level, most of the down-regulated genes were derived from symbionts. (3) Through similarity searches to data from other species, a number of protein sequences putatively involved in chemosensory reception were identified and characterized inC. formosanus, including odorant receptors, gustatory receptors, ionotropic receptors, odorant binding proteins, and chemosensory proteins.DiscussionWe found that most genes associated with carbohydrate metabolism, energy metabolism, and genetic information processing were regulated under different CO2concentrations. Results suggested that termites adapt to ∼4% CO2level and their gut symbionts may be killed under high CO2level. We anticipate that our findings provide insights into the transcriptome dynamics of CO2responses in termites and form the basis to gain a better understanding of regulatory networks.
“Everyday I’m Çapuling”
Authors: Odağ Özen , Melis Uluğ Özden , Solak Nevin 
Published: October 2016

Abstract. This contribution examines the 2013 Gezi Park protests in Turkey by drawing on the social identity model of collective action (SIMCA) and the slacktivism versus facilitation debate in the literature on digitally enabled collective action. Contrary to the slacktivism hypothesis that claims online collective action to lack an apparent impact on the real world, the current study indicates a facilitating role of online collective action in the Gezi Park protests. By means of a large-scale online survey (N = 1,127) and a subsequent latent path analysis, the study demonstrates that the endurance of the movement was kept alive by both offline and online collective actions. The relationship between offline/online action and protest motivations was mediated by three predictors of collective action derived from the SIMCA: perceived injustice, social identity, and perceived efficacy. Results show that protestors in Turkey, independent of whether they became active in the digital or the real world, were likely to protest again to the extent that they perceived developments in Turkey as unjust, identified strongly with the Çapulcus [Turkish for looters] as a social group, and perceived this group to be efficient in changing social injustice in the country.
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
Authors: Gordon Richard , Neal Matthew L. , Luo Jie , Langley Monica R. , Harischandra Dilshan S. , Panicker Nikhil , Charli Adhithiya , Jin Huajun , Anantharam Vellareddy , Woodruff Trent M. , Zhou Qun-Yong , Kanthasamy Anumantha G. , Kanthasamy Arthi 
Published: October 2016

AbstractProkineticin-2 (PK2), a recently discovered secreted protein, regulates important physiological functions including olfactory biogenesis and circadian rhythms in the CNS. Interestingly, although PK2 expression is low in the nigral system, its receptors are constitutively expressed on nigrostriatal neurons. Herein, we demonstrate that PK2 expression is highly induced in nigral dopaminergic neurons during early stages of degeneration in multiple models of Parkinson’s disease (PD), including PK2 reporter mice and MitoPark mice. Functional studies demonstrate that PK2 promotes mitochondrial biogenesis and activates ERK and Akt survival signalling pathways, thereby driving neuroprotection. Importantly, PK2 overexpression is protective whereas PK2 receptor antagonism exacerbates dopaminergic degeneration in experimental PD. Furthermore, PK2 expression increased in surviving nigral dopaminergic neurons from PD brains, indicating that PK2 upregulation is clinically relevant to human PD. Collectively, our results identify a paradigm for compensatory neuroprotective PK2 signalling in nigral dopaminergic neurons that could have important therapeutic implications for PD.
Pre-eruptive magmatic processes re-timed using a non-isothermal approach to magma chamber dynamics
Authors: Petrone Chiara Maria , Bugatti Giuseppe , Braschi Eleonora , Tommasini Simone 
Published: October 2016

AbstractConstraining the timescales of pre-eruptive magmatic processes in active volcanic systems is paramount to understand magma chamber dynamics and the triggers for volcanic eruptions. Temporal information of magmatic processes is locked within the chemical zoning profiles of crystals but can be accessed by means of elemental diffusion chronometry. Mineral compositional zoning testifies to the occurrence of substantial temperature differences within magma chambers, which often bias the estimated timescales in the case of multi-stage zoned minerals. Here we propose a new Non-Isothermal Diffusion Incremental Step model to take into account the non-isothermal nature of pre-eruptive processes, deconstructing the main core-rim diffusion profiles of multi-zoned crystals into different isothermal steps. The Non-Isothermal Diffusion Incremental Step model represents a significant improvement in the reconstruction of crystal lifetime histories. Unravelling stepwise timescales at contrasting temperatures provides a novel approach to constraining pre-eruptive magmatic processes and greatly increases our understanding of magma chamber dynamics.
Polymer Nanodot-Hybridized Alkyl Silicon Oxide Nanostructures for Organic Memory Transistors with Outstanding High-Temperature Operation Stability
Authors: Lee Chulyeon , Seo Jooyeok , Kim Jeongnam , Jeong Jaehoon , Han Hyemi , Kim Hwajeong , Kim Youngkyoo 
Published: October 2016

AbstractOrganic memory devices (OMDs) are becoming more important as a core component in flexible electronics era because of their huge potentials for ultrathin, lightweight and flexible plastic memory modules. In particular, transistor-type OMDs (TOMDs) have been gradually spotlighted due to their structural advantages possessing both memory and driving functions in single devices. Although a variety of TOMDs have been developed by introducing various materials, less attention has been paid to the stable operation at high temperatures. Here we demonstrate that the polymer nanodot-embedded alkyl silicon oxide (ASiO) hybrid materials, which are prepared by sol-gel and thermal cross-linking reactions between poly(4-vinylphenol) (PVP) and vinyltriethoxysilane, can deliver low-voltage (1~5 V) TOMDs with outstanding operation stability (>4700 cycles) at high temperatures (150 °C). The efficient low-voltage memory function is enabled by the embedded PVP nanodots with particular lattice nanostructures, while the high thermal stability is achieved by the cross-linked ASiO network structures.
Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating
Authors: Mukherjee Saptarshi , Thomas N. Lowri , Williams Alan J. 
Published: October 2016

AbstractThe flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively, shedding light on the mechanisms underlying gating. Recent investigations have focused on ion occupancy of the channel’s selectivity filter and its ability to alter gating, with most studies involving prokaryotic K+ channels. Some studies used large quaternary ammonium blocker molecules to examine the effects of altered ionic flux on gating. However, the absence of blocking events that are visibly distinct from closing events in K+ channels makes unambiguous interpretation of data from single channel recordings difficult. In this study, the large K+ conductance of the RyR2 channel permits direct observation of blocking events as distinct subconductance states and for the first time demonstrates the differential effects of blocker molecules on channel gating. This experimental platform provides valuable insights into mechanisms of blocker-induced modulation of ion channel gating.
Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer
Authors: Flores-Pérez Ali , Marchat Laurence A. , Rodríguez-Cuevas Sergio , Bautista-Piña Verónica , Hidalgo-Miranda Alfredo , Ocampo Elena Aréchaga , Martínez Mónica Sierra , Palma-Flores Carlos , Fonseca-Sánchez Miguel A. , Astudillo-de la Vega Horacio , Ruíz-García Erika , González-Barrios Juan Antonio , Pérez-Plasencia Carlos , Streber María L. , López-Camarillo César 
Published: October 2016

AbstractDeregulated expression of microRNAs has been associated with angiogenesis. Studying the miRNome of locally advanced breast tumors we unsuspectedly found a dramatically repression of miR-204, a small non-coding RNA with no previous involvement in tumor angiogenesis. Downregulation of miR-204 was confirmed in an independent cohort of patients and breast cancer cell lines. Gain-of-function analysis indicates that ectopic expression of miR-204 impairs cell proliferation, anchorage-independent growth, migration, invasion, and the formation of 3D capillary networks in vitro. Likewise, in vivo vascularization and angiogenesis were suppressed by miR-204 in a nu/nu mice model. Genome-wide profiling of MDA-MB-231 cells expressing miR-204 revealed changes in the expression of hundred cancer-related genes. Of these, we focused on the study of pro-angiogenic ANGPT1 and TGFβR2. Functional analysis using luciferase reporter and rescue assays confirmed that ANGPT1 and TGFβR2 are novel effectors downstream of miR-204. Accordingly, an inverse correlation between miR-204 and ANGPT1/TGFβR2 expression was found in breast tumors. Knockdown of TGFβR2, but not ANGPT1, impairs cell proliferation and migration whereas inhibition of both genes inhibits angiogenesis. Taken altogether, our findings reveal a novel role for miR-204/ANGPT1/TGFβR2 axis in tumor angiogenesis. We propose that therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer.
Measuring populations to improve vaccination coverage
Authors: Bharti Nita , Djibo Ali , Tatem Andrew J. , Grenfell Bryan T. , Ferrari Matthew J. 
Published: October 2016

AbstractIn low-income settings, vaccination campaigns supplement routine immunization but often fail to achieve coverage goals due to uncertainty about target population size and distribution. Accurate, updated estimates of target populations are rare but critical; short-term fluctuations can greatly impact population size and susceptibility. We use satellite imagery to quantify population fluctuations and the coverage achieved by a measles outbreak response vaccination campaign in urban Niger and compare campaign estimates to measurements from a post-campaign survey. Vaccine coverage was overestimated because the campaign underestimated resident numbers and seasonal migration further increased the target population. We combine satellite-derived measurements of fluctuations in population distribution with high-resolution measles case reports to develop a dynamic model that illustrates the potential improvement in vaccination campaign coverage if planners account for predictable population fluctuations. Satellite imagery can improve retrospective estimates of vaccination campaign impact and future campaign planning by synchronizing interventions with predictable population fluxes.
Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
Authors: Tang Yu-Jin , Wang Jun-Li , Xie Ke-Gong , Lan Chang-Gong 
Published: October 2016

AbstractInterleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patients with OS and 402 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. Plasma IL16 level was measured by enzyme-linked immunosorbent assay. Rs11556218 was associated with an increased risk of OS in heterozygote comparison (adjusted OR = 1.65, 95% CI, 1.23–2.21, P < 0.001), dominant model (adjusted OR = 1.66, 95% CI, 1.24–2.21, P < 0.001), and allele comparison (adjusted OR = 1.44, 95% CI, 1.14–1.81, P = 0.002). Moreover, rs11556218 TG/GG genotypes were associated with higher levels of IL16 as compared to TT genotype (P = 0.03). However, no significant association of rs4778889 and rs4072111 and OS was found. These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.
A comprehensive insight into functional profiles of free-living microbial community responses to a toxic Akashiwo sanguinea bloom
Authors: Yang Caiyun , Li Yi , Zhou Yanyan , Lei Xueqian , Zheng Wei , Tian Yun , Van Nostrand Joy D. , He Zhili , Wu Liyou , Zhou Jizhong , Zheng Tianling 
Published: October 2016

AbstractPhytoplankton blooms are a worldwide problem and can greatly affect ecological processes in aquatic systems, but its impacts on the functional potential of microbial communities are limited. In this study, a high-throughput microarray-based technology (GeoChip) was used to profile the functional potential of free-living microbes from the Xiamen Sea Area in response to a 2011 Akashiwo sanguinea bloom. The bloom altered the overall community functional structure. Genes that were significantly (p < 0.05) increased during the bloom included carbon degradation genes and genes involved in nitrogen (N) and/or phosphorus (P) limitation stress. Such significantly changed genes were well explained by chosen environmental factors (COD, nitrite-N, nitrate-N, dissolved inorganic phosphorus, chlorophyll-a and algal density). Overall results suggested that this bloom might enhance the microbial converting of nitrate to N2 and ammonia nitrogen, decrease P removal from seawater, activate the glyoxylate cycle, and reduce infection activity of bacteriophage. This study presents new information on the relationship of algae to other microbes in aquatic systems, and provides new insights into our understanding of ecological impacts of phytoplankton blooms.
l-Ornithine affects peripheral clock gene expression in mice
Authors: Fukuda Takafumi , Haraguchi Atsushi , Kuwahara Mari , Nakamura Kaai , Hamaguchi Yutaro , Ikeda Yuko , Ishida Yuko , Wang Guanying , Shirakawa Chise , Tanihata Yoko , Ohara Kazuaki , Shibata Shigenobu 
Published: October 2016

AbstractThe peripheral circadian clock is entrained by factors in the external environment such as scheduled feeding, exercise, and mental and physical stresses. In addition, recent studies in mice demonstrated that some food components have the potential to control the peripheral circadian clock during scheduled feeding, although information about these components remains limited. l-Ornithine is a type of non-protein amino acid that is present in foods and has been reported to have various physiological functions. In human trials, for example, l-ornithine intake improved a subjective index of sleep quality. Here we demonstrate, using an in vivo monitoring system, that repeated oral administration of l-ornithine at an early inactive period in mice induced a phase advance in the rhythm of PER2 expression. By contrast, l-ornithine administration to mouse embryonic fibroblasts did not affect the expression of PER2, indicating that l-ornithine indirectly alters the phase of PER2. l-Ornithine also increased plasma levels of insulin, glucose and glucagon-like peptide-1 alongside mPer2 expression, suggesting that it exerts its effects probably via insulin secretion. Collectively, these findings demonstrate that l-ornithine affects peripheral clock gene expression and may expand the possibilities of L-ornithine as a health food.
Production of O2 through dismutation of H2O2 during water ice desorption: a key to understanding comet O2 abundances
Authors: Dulieu F. , Minissale M. , Bockelée-Morvan D. 
Published: October 2016

Context. Detection of molecular oxygen and prediction of its abundance have long been a challenge for astronomers. The low abundances observed in few interstellar sources are well above the predictions of current astrochemical models. During the Rosetta mission, an unexpectedly high abundance of O2 was discovered in the comet 67P/Churyumov-Gerasimenko’s coma. A strong correlation between O2 and H2O productions is observed, whereas no such correlation is observed between O2 and either of CO or N2.
Aims. We suggest that the O2 molecule may be formed during the evaporation of water ice. We propose a possible reaction: the dismutation of H2O2 (2 H2O2−→ 2 H2O + O2), a molecule which should be co-produced during the water ice mantle growth on dust grains. We aim to test this hypothesis under realistic experimental conditions.
Methods. We performed two sets of experiments. They consist of producing a mixture of D2O and D2O2 via the reaction of O2 and D on a surface held at 10 K. The first set is made on a silicate substrate, and explores the limit of thin films, in order to prevent any complication due to trapping during the desorption. The second set is performed on a pre-deposited H2O ice substrate and mimics the desorption of mixed ice.
Results. In thin films, O2 is produced by the dismutation of H2O2, even at temperatures as low as 155 K. Mixed with water, H2O2 desorbs after the water ice sublimation and even more desorption of O2 is observed.
Conclusions. H2O2, synthesised during the growth of interstellar ices (or by later processing), desorbs at the latest stage of the water sublimation and undergoes the dismutation reaction. Therefore an O2 release in the gas phase should occur at the end of the evaporation of ice mantles. Temperature gradients along the geometry of clouds, or interior of comets, should blend the different stages of the sublimation. Averaged along the whole process, a mean value of the O2/H2O ratio of a few percent in the gas phase seems plausible.