bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Metal Complexes in Organic Synthesis. Preparation of α‐(1‐Adamantyl)‐β‐dicarbonyl Compounds and 4‐(1‐Adamantyl)‐3,5‐disubstituted Pyrazoles and Isoxazoles.
Authors: GONZALEZ A. , MARQUET J. , MORENO‐MANAS M. 
Published: May 2016

AbstractAdamantyl substituted heterocycles have anticancer and antiviral properties.
ChemInform Abstract: A Selective Synthesis of Unsymmetrical 1,1′‐Methylene‐bisdiazoles by Solid‐Liquid Phase Transfer Catalysis.
Authors: JULIA S. , MARTINEZ‐MARTORELL C. , ELGUERO J. 
Published: May 2016

AbstractDie aus den Pyrazolen (I) bzw. Benzimidazolen (IV) gemäß Schema zugänglichen N‐Chlormethyl‐Derivate (III) bzw. (VIb) reagieren mit den Diazolen (VII) bzw. (IVb) unter Phasen‐Transfer‐Katalyse zu den Methylen‐ bis‐diazolen (VIII) bzw. (IX).
ChemInform Abstract: Synthesis of Nα‐(2‐Naphthylsulfonylglycyl)‐4‐aminomethyl‐ and ‐4‐aminophenylalaninpiperidide as Thrombin Inhibitors.
Authors: HORN H. , WAGNER G. 
Published: May 2016

AbstractDas Sulfonylglycylchlorid (I) liefert mit Nitrophenylalanin (II) das Amid (III), das mit Chlorameisensäureester (IV) und Piperidin (V) zu dem Piperidid (VI) reagiert.
ChemInform Abstract: One‐Step Synthesis of 5‐Acylamino‐2,2‐dialkyl‐4‐oxo‐1,3‐dioxanes: A Cyclic System Enabling Simultaneous Protection of Hydroxyl and Carboxyl Functions in α‐Hydroxymethyl‐α‐amino Acids.
Authors: KAMINSKI Z. J. , LEPLAWY M. T. 
Published: May 2016

AbstractThe dioxane derivatives (III) are prepared from the α‐alkylserines (I) and the aliphatic acetals (II) in the presence of acids.
ChemInform Abstract: N‐Phenyl‐N‐(α‐phenylphenacyl)oxamoyl Chloride in Heterocyclic Synthesis: Preparation of Imidazo[1,2‐d]‐1,2,4‐triazine Derivatives.
Authors: MOLINA P. , TARRAGA A. , LIDON M. J. 
Published: May 2016

AbstractOxamoyl Chloride (II), which is easily obtained from the aniline (I) and oxalyl Chloride, forms the triazine derivatives (IV) on reaction with the amidrazones (III).
ChemInform Abstract: Preparation of 7‐Alkyl‐2,3,6,7‐tetrahydro‐4‐alkyl‐2‐oxo‐1H‐1,3‐diazepine‐5‐carboxylates by Ring Expansion Nucleophilic Addition.
Authors: CLAREMON D. A. , ROSENTHAL S. A. 
Published: May 2016

AbstractThe reaction of the pyrimidine derivatives (I) with the Grignard reagents (II) proceeds under ring expansion and nucleophilic addition to yield the title compounds (III).
ChemInform Abstract: Synthesis of Fluorinated Polysiloxanes. Part 2. Addition of Fluorinated Thiols to Unsaturated Silanes.
Authors: BOUTEVIN B. , PIETRASANTA Y. , SARRAF L. 
Published: May 2016

AbstractDie radikalisch initiierte Reaktion des Polyfluoralkylthiols (I) mit den Vinyl‐ und Alkenylsilanen (II) liefert die Additionsprodukte (III).
ChemInform Abstract: Synthesis and X‐Ray Crystal Structure of a Novel Bimetallic Bis(η5‐dicarbollide) Aluminum Sandwich Complex.
Authors: REES W. S. JUN. , SCHUBERT D. M. , KNOBLER C. B. , HAWTHORNE M. F. 
Published: May 2016

AbstractA benzene solution of (I) leads by a CO‐catalyzed reaction to the novel air‐sensitive, crystalline aluminacarborane sandwich complex (II).
ChemInform Abstract: Hydrido Methylidene, Hydrido Vinylidene, Hydrido Oxo, and Hydrido Formaldehyde Derivatives of Bis(pentamethylcyclopentadienyl)tantalum.
Authors: VAN ASSELT A. , BURGER B. J. , GIBSON V. C. , BERCAW J. E. 
Published: May 2016

AbstractThe reaction of the dichloride (I) with two equiv. MeLi affords the hydrido methylidene derivative (II).
ChemInform Abstract: Experimental Probes of the Electronic Matrix Element Contributions to Bimolecular Reactions. The Electronic Energy Transfer Reactions of (2E)‐Chromium(IIl)‐Poly‐pyridyl Complexes with Transition‐Metal Acceptors.
Authors: ENDICOTT J. F. , TAMILARASAN R. , BRUBAKER G. R. 
Published: May 2016

AbstractThe rates have been determined for quenching of the title Cr complexes (polypyridyl: 1,10‐phenanthroline and its derivatives) by a variety of Co (III) amine complexes.
ChemInform Abstract: Generation and Reactions of Carbanions in the Presence of a Neighboring η3‐Allyl‐Mo(CO)2Cp Moiety. A Novel Rearrangement Suggesting Participation of Mo in Carbanion Stabilization.
Authors: PEARSON A. J. , HOLDEN M. S. , SIMPSON R. D. 
Published: May 2016

AbstractThe allyl bromide (I) is converted to the Mo‐complexes (IV) and (V).
ChemInform Abstract: Observations on the Formation of HFe3(CO)11‐ on Hydroxylated γ‐Al2O3.
Authors: HANSON B. E. , BERGMEISTER J. J. III , PETTY J. T. , CONNAWAY M. C. 
Published: May 2016

AbstractHydrocarbon solutions of Fe3(CO)12 are adsorbed on hydroxylated γ‐Al2O3.
ChemInform Abstract: Oxidative Addition of Quinones to Planar Cobalt(II) Dithiolato, Dithioacetylacetonato and Schiff‐base Complexes.
Authors: HARTL F. , VLCEK A. JUN. 
Published: May 2016

AbstractThe reactivity of the o‐ and p‐quinones (II) and(IV) with various four‐coordinated planar Co(II) complexes (I) is investigated by means of ESR and UV/VIS absorption spectroscopy.
ChemInform Abstract: Coreceptor Molecules. Synthesis of Metalloreceptors Containing Porphyrin Subunits and Formation of Mixed Substrate Supermolecules by Binding of Organic Substrates and of Metal Ions.
Authors: HAMILTON A. , LEHN J.‐M. , SESSLER J. L. 
Published: May 2016

AbstractThe condensation of the porphyrin diesters (I) with the biphenylene‐bridged bis‐macrocycle (II) (preparation described) led to the tetraamides (IIIa).
ChemInform Abstract: A Metal‐Centered Radical‐Pair Mechanism for Alkyne Hydrogenation with a Binuclear Rhodium Hydride Complex. CIDNP without Organic Radicals.
Authors: HOMMELTOFT S. I. , BERRY D. H. , EISENBERG R. 
Published: May 2016

AbstractComplex (I)reacts rapidly with phenylacetylene (II) in C6D6 under H2 to give styrene (IV) and a complex (III), which slowly converts to the more stable isomer containing μ2,η2‐alkyne bridge.
ChemInform Abstract: Synthesis of L‐Glutamic Acid Stereospecifically Labelled at C‐4 with Tritium: Stereochemistry of Tritium Release Catalyzed by the Vitamin K‐Dependent Carboxylase in the Absence of Carboxylation.
Authors: DUCROCQ C. , RIGHINI‐TAPIE A. , AZERAD R. , GREEN J. F. , FRIEDMAN P. A. , BEAUCOURT J.‐P. , ROUSSEAU B. 
Published: May 2016

AbstractThe isomeric halogen esters (III) and (IV) (separable mixture) are prepared from the racemic mesylate (I). However, only the tritiated isomer (Va) can be satisfactorily obtained using (IV); when (III) is used, a mixture of (Va) and its isomer (Vb) is obtained.
ChemInform Abstract: 5‐Deoxy‐5‐fluoro‐D‐glucofuranose and ‐L‐idofuranose Synthesis and NMR Studies.
Authors: ALBERT R. , DAX K. , SEIDL S. , STERK H. , STUETZ A. E. + 
Published: May 2016

AbstractAusgehend von dem Lacton (Ia) wird über das Triflat (Ib) durch nucleophile Substitution die Fluorverbindung (II) dargestellt.
ChemInform Abstract: Total Synthesis of Podophyllum Lignans: An Exploratory Study.
Authors: VAN DER EYCKEN J. , DE CLERCQ P. , VANDEWALLE M. 
Published: May 2016

AbstractOn the basis of stereochemical considerations, the compound (IXb) seems to be an appropriate precursor for the podophyllotoxin system (I) because the cis‐substituted dioxane ring could be an essential stereocontrolling element.
ChemInform Abstract: Studies on β‐Lactam Antibiotics for Medicinal Purpose. Part 18. Synthesis and Structure‐Activity Relationships of 7β‐[(Z)‐2‐(2‐Aminothiazol‐4‐yl)‐2‐methoxyiminoacetamido]‐3‐substituted Methyl‐3‐cephem‐4‐carboxylic Acid Derivatives.
Authors: SADAKI H. , IMAIZUMI H. , INABA T. , HIRAKAWA T. , MUROTANI Y. , WATANABE Y. , MINAMI S. , SAIKAWA I. 
Published: May 2016

AbstractAus der Thiazolcarbonsäure (I) werden mit den β‐Lactamen (II) nach mehreren Verfahrensvarianten die Cephalosporine (III) hergestellt.
Numerische Simulationen der katalytischen Methanisierung von CO2 in einem pseudo‐homogenen Strömungsrohr
Authors: Ghaib Karim 
Published: May 2016

AbstractPower‐to‐Gas ist eine attraktive Option zur Speicherung der Stromüberschüsse aus fluktuierenden erneuerbaren Energiequellen. Das Konzept gewann in den letzten Jahren an Bedeutung. Ein wesentlicher Teil der Prozesskette des Power‐to‐Gas ist die katalytische Methanisierung von CO2. Im Rahmen dieser Arbeit wird die katalytische Methanisierung von reinem CO2 und von Biogas in einem dreidimensionalen polytropen pseudo‐homogenen Strömungsrohr modelliert und bei verschiedenen Lasten numerisch simuliert. Die Ergebnisse stellen axiale sowie radiale quantitative Informationen über das Reaktionsverhalten unter den verschiedenen Randbedingungen dar.
Filling the gaps in knowledge and treatments for sexual health in young adult male cancer survivors
Authors: Syrjala Karen L. 
Published: May 2016

Male survivors of childhood cancer will spend their entire adult lives with the late effects of treatment on their sexual health. A valuable article in this issue makes it clear that the sexual difficulties in these survivors, who most often are treated for hematologic malignancies like acute lymphoblastic leukemia, differ from those in men who are treated for prostate or testicular cancer, and their sexual function treatments must be adapted to fit those needs.See also pages 2268–76.
Changes in the survival of older patients with hematologic malignancies in the early 21st century
Authors: Pulte Dianne , Jansen Lina , Castro Felipe A. , Brenner Hermann 
Published: May 2016

BACKGROUNDSurvival for patients with hematologic malignancies has improved during the early 21st century. However, it is unclear whether older patients have benefited to the same extent as younger patients. This study examines changes in survival for older patients with the 7 most common hematologic malignancies.METHODSPeriod analysis was used to examine survival for patients who were 65 years old or older and were diagnosed with a common hematologic malignancy between 1992 and 2012 with data from the Surveillance, Epidemiology, and End Results database.RESULTSFive‐year relative survival increased for older patients with hematologic malignancies with the partial exception of acute myelogenous leukemia, for which no change in survival was seen for patients who were 75 years old or older. Patients with chronic lymphocytic leukemia and non‐Hodgkin lymphoma, including the oldest patients, had especially strong improvements, with increases in 5‐year relative survival for patients who were 85 years old or older of 31.5% and 39.6%, respectively, between 1997‐2000 and 2009‐2012.CONCLUSIONSDespite these increases, survival rates did not reach those observed for patients aged 50 to 59 years for any hematologic malignancy. Newer therapies and a better understanding of how to treat older patients have led to increased survival expectations for older patients with most hematologic malignancies, but an age‐related survival disparity persists. Cancer 2016;122:2031–40. © 2016 American Cancer Society.
Concurrent chemoradiotherapy versus radiotherapy alone for “biopsy‐only” glioblastoma multiforme
Authors: Kole Adam J. , Park Henry S. , Yeboa Debra N. , Rutter Charles E. , Corso Christopher D. , Aneja Sanjay , Lester‐Coll Nataniel H. , Mancini Brandon R. , Knisely Jonathan P. , Yu James B. 
Published: May 2016

BACKGROUNDCombined temozolomide and radiotherapy (RT) is the standard postoperative therapy for glioblastoma multiforme (GBM). However, the clearest benefit of concurrent chemoradiotherapy (CRT) observed in clinical trials has been among patients who undergo surgical resection. Whether the improved survival with CRT extends to patients who undergo “biopsy only” is less certain. The authors compared overall survival (OS) in a national cohort of patients with GBM who underwent biopsy and received either RT alone or CRT during the temozolomide era.METHODSThe US National Cancer Data Base was used to identify patients with histologically confirmed, biopsy‐only GBM who received either RT alone or CRT from 2006 through 2011. Demographic and clinicopathologic predictors of treatment were analyzed using the chi‐square test, the t test, and multivariable logistic regression. OS was evaluated using the log‐rank test, multivariable Cox proportional hazard regression, and propensity score‐matched analysis.RESULTSIn total, 1479 patients with biopsy‐only GBM were included, among whom 154 (10.4%) received RT alone and 1325 (89.6%) received CRT. The median age at diagnosis was 61 years. CRT was associated with a significant OS benefit compared with RT alone (median, 9.2 vs 5.6 months; hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.54‐0.76; P < .001). CRT was independently associated with improved OS compared with RT alone on multivariable analysis (HR, 0.71; 95% CI, 0.60‐0.85; P < .001). A significant OS benefit for CRT persisted in a propensity score‐matched analysis (HR, 0.72; 95% CI, 0.56‐0.93; P = .009).CONCLUSIONSThe current data suggest that CRT significantly improves OS in patients with GBM who undergo biopsy only compared with RT alone and should remain the standard of care for patients who can tolerate therapy. Cancer 2016;122:2364–2370. © 2016 American Cancer Society.
Open‐Label, Randomized, 6‐Way Crossover, Single‐Dose Study to Determine the Pharmacokinetics of Batefenterol (GSK961081) and Fluticasone Furoate When Administered Alone or in Combination
Authors: Ambery Claire , Riddell Kylie , Daley‐Yates Peter 
Published: May 2016

AbstractTo investigate the pharmacokinetics of inhaled batefenterol (BAT) and fluticasone furoate (FF) given alone or in combination via ELLIPTA® dry powder inhaler (DPI‐E), and BAT monotherapy via DISKUS® DPI (DPI‐D). In this open‐label, 6‐way crossover study, 48 healthy subjects were randomized to 1 of 6 treatment sequences, comprising 6 single‐dose treatment regimens: (1) BAT 1200 μg via DPI‐D; (2) BAT 1200 μg via DPI‐E without a lactose‐filled second strip; (3) BAT 1200 μg via DPI‐E with a lactose‐filled second strip; (4) BAT/FF 1200/300 μg via DPI‐E; (5) FF 300 μg via DPI‐E with a lactose‐filled second strip; and (6) BAT/FF 900/300 μg via DPI‐E. Pharmacokinetic data were analyzed using noncompartmental methods. Plasma BAT area under the curve (AUC) and maximum plasma concentration (Cmax) were similar for all treatments containing BAT 1200 μg (geometric least‐squares means [GLSM] ratio, 0.90–1.06). Plasma FF AUC and Cmax were reduced following BAT/FF 1200/300 μg and 900/300 μg versus FF 300 μg monotherapy (GLSM ratio, 0.62–0.77). BAT 1200 μg administered via DPI‐E, alone or in combination with FF, resulted in similar systemic exposure versus BAT administered by DPI‐D. FF exposure was reduced when administered in combination with BAT compared with FF alone.
Patterns of joint parasympathetic, sympathetic, and adrenocortical activity and their associations with temperament in early childhood
Authors: Kolacz Jacek , Holochwost Steven J. , Gariépy Jean‐Louis , Mills‐Koonce W. Roger 
Published: May 2016

AbstractEvidence has accrued to show that autonomic and adrenocortical systems act in coordination to facilitate responses to environmental opportunities and threats. In the current study, we used cluster analysis to examine whether individual differences in patterns of joint baseline activity among the parasympathetic and sympathetic branches of the autonomic nervous system with the hypothalamic‐pituitary‐adrenal axis are associated with parent‐reported temperamental positive and negative affectivity in 36‐month old children. The resulting clusters corresponded to the sensitive, buffered, and vigilant patterns as predicted by the adaptive calibration model of stress responsivity (Del Giudice et al., 2011) and included a novel pattern. Cluster memberships predicted differences in overall negative affectivity and its subscales, but no associations were found with positive affectivity. These results provide evidence that the joint activity of physiological systems at rest may underlie temperamental differences in negative affect.
Fertilization limitation of Diadema antillarum on coral reefs in the Florida Keys
Authors: Feehan Colette J. , Brown Michael S. , Sharp William C. , Lauzon‐Guay Jean‐Sébastien , Adams Diane K. 
Published: May 2016

AbstractMass mortality of the sea urchin Diadema antillarum due to disease outbreaks in 1983 and 1991 decimated populations in the Florida Keys, and they have yet to recover. Here, we use a coupled advection–diffusion and fertilization–kinetics model to test the hypothesis that these populations are fertilization limited. We found that fertilization success was ≥ 96% prior to the first disease outbreak, decreased substantially following recurrent disease to 3%, and has since remained low. By investigating the combined effects of physical factors (population spatial extent and current velocity) and sea urchin behavior (aggregation) on density‐dependent fertilization success, we show that fertilization success at a given density increases with increasing population spatial extent and decreasing current velocity, and is greater under simulated aggregation behavior of D. antillarum. However, at present population densities, the increase in fertilization success due to aggregation is < 1%, even under the most favorable physical conditions. These results indicate that populations are severely fertilization limited, and that Allee effects at low population density will continue to limit recovery. Our results can serve as a practical guide to managers in the development of coral reef restoration strategies, including the design of a D. antillarum restocking program to obtain reproductively viable populations.
Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study
Authors: Biegus Jan , Hillege Hans L. , Postmus Douwe , Valente Mattia. A.E. , Bloomfield Daniel M. , Cleland John G.F. , Cotter Gad , Davison Beth A. , Dittrich Howard C. , Fiuzat Mona , Givertz Michael M. , Massie Barry M. , Metra Marco , Teerlink John R. , Voors Adriaan A. , O'Connor Christopher M. , Ponikowski Piotr 
Published: May 2016

AimsEpisodes of acute heart failure (AHF) unfavourably affect multiple organs, which may have an adverse impact on the outcomes. We investigated the prevalence and clinical consequences of abnormal liver function tests (LFTs) in AHF patients enrolled in the PROTECT study.Methods and resultsThe LFTs comprised serial assessment of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and albumin at baseline and during follow‐up (daily until discharge, on days 7 and 14). The prevalence of abnormal LFTs (above upper limit of normal for AST and ALT or below lower limit of normal for albumin) was: at baseline AST 20%, ALT 12%, albumin 40%; and at day 14: AST 15%, ALT 9%, albumin 26%. Abnormal LFTs at baseline were associated with a higher risk of in‐hospital death with odds ratios [95% confidence interval (CI)] of 3.5 (1.7–7.3) for AST, 3.9 (1.8–8.4) for ALT, and 2.8 (1.3–5.9) for albumin (all P < 0.01). Abnormal baseline and discharge LFTs had an unfavourable impact on 180‐day mortality with hazard ratios (95% CI) for baseline AST, ALT, and albumin of 1.3 (1.0–1.7), 1.1 (1.0–1.2), 1.4 (1.1–1.8), respectively, and 1.5 (1.1–2.0), 1.5 (1.0–2.2), and 1.6 (1.2–2.1), for discharge AST, ALT, albumin, respectively (all P < 0.05). Analysis of LFTs trajectories (calculated as changes in LFTs over time) revealed that increasing AST and ALT on day 3 as well as decreasing albumin on day 4 were independent prognosticators of 180‐day outcome (all P < 0.05).ConclusionsAbnormal LFTs are frequent in AHF at baseline and during hospital stay and predict worse outcomes. Whether this association is causal and what are the underlying mechanisms involved require further study.
Is the brain of complex regional pain syndrome patients truly different?
Authors: van Velzen G.A.J. , Rombouts S.A.R.B. , van Buchem M.A. , Marinus J. , van Hilten J.J. 
Published: May 2016

AbstractBackgroundIn recent years, changes in brain structure and function have been studied extensively in patients with complex regional pain syndrome (CRPS) following clinical observations of altered central processing of sensory stimuli and motor control. However, concerning MRI data, the evidence is complex to interpret due to heterogeneity in statistical methods and results.MethodThe aim of this study was to determine if CRPS patients exhibit specific, clinically relevant changes in brain structure and function in rest. We do this by presenting MRI data on brain structure and function in 19 chronic, female CRPS patients and age‐ and sex‐matched healthy controls (HCs). In addition, we analyse and report the data in multiple ways to make comparison with previous studies possible and to demonstrate the effect of different statistical methods, in particular, concerning the correction for multiple testing.ResultsUsing family‐wise error (FWE) correction for multiple testing, in our group of CRPS patients, we find no specific difference in brain structure or function in rest in comparison to HCs. In addition, we argue that previously found MRI results in the literature are inconsistent in terms of localization, quantity and directionality of the reported changes in brain structure and function.ConclusionPreviously published MRI‐based evidence for altered brain structure and function in rest in CRPS patients is not consistent and our data suggests that no such phenomenon exists.What does this study add?This article does not replicate the previous found results. The reported evidence in MRI literature of aberrant neuroplasticity in CRPS patients is inconsistent in terms of localization, quantity and directionality of changes in brain structure and function.
Electrochemical Oxidation of Astaxanthin on Glassy‐carbon Electrode and its Amperometric Determination Using Batch Injection Analysis (BIA)
Authors: Oliveira Gracy K. F. , Tormin Thiago F. , de O. Montes Rodrigo H. , Richter Eduardo M. , Muñoz Rodrigo A. A. 
Published: May 2016

AbstractThis work presents the electrochemical oxidation of the antioxidant astaxanthin on a glassy‐carbon electrode (GCE) and its amperometric determination in salmon samples using a batch‐injection analysis (BIA) system. The proposed BIA method consisted of 80‐µL a fast microliter injection of sample at 193 µL s−1 on the GCE immersed in the electrolyte, a mixture of acetone, dichloromethane, and water (80 : 10 : 10 v/v), containing 0.1 mol L−1 HClO4. Advantages include high precision (RSD of 2.4 %), sample throughput of 240 h−1, and low detection limit (0.3 µmol L−1 that corresponds to 0.1 µg g−1) for the analysis of acetone extracts of salmon samples. Recovery values between 83 and 97 % attested the accuracy of the method.