bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking the Therapeutic Potential of Medicinal Hemp: Insights into Pharmacokinetics and Metabolism of Cannabinoids
Authors: Shah Syed Sabir Hussain , Latif Saba , Qureshi Rahmatullah 
Published: September 2024

Abstract:
Medicinal hemp or Cannabis (Cannabis sativa L.) is one of the earliest herbs widely
used in traditional medicine by human beings for millions of years. This species was originally
thought to be endemic to Asian countries but has now grown worldwide. It is a dioecious and annual
plant that belongs to the Cannabaceae family. It has a long history of cultivation for food,
intoxicants, hemp medicine, rope, paper, fiber, and oil extraction. Due to its diverse therapeutic
properties, it is legalized in over 50 countries and cultivated as a medicinal and recreational crop.
This review was aimed at collecting information about medicinal cannabis, ranging from traditional
use to commercial utilization. This review article is based on gathering scientific literature
from Google Scholar, Scopus, PubMed, Science Direct, Wiley Online Library, Taylor Francis,
and Springer with 119 documents, including original articles, review articles, books, and thesis
from 1973 to 2024. So far, more than 500 phytochemicals have been identified. Phytocannabinoids
are thought to be the main bioactive ingredients that produce therapeutic benefits. These
are mostly produced or synthesized in secretary cells located inside of glandular trichomes that
are found in the female inflorescence or flowers of hemp crop. Cannabidiol (CBD) has strong
therapeutic potential and is used to cure many fatal diseases. A thorough understanding of the
pharmacokinetics and metabolism of medicinal hemp is vital for tailoring treatment approaches
and minimizing adverse effects. The effect and severity of Cannabidiol (CBD) and tetrahydrocannabinol
(THC) are determined by the route of application and their dose. It can be concluded
that much of the work needs to be done for the validation of ethnobotanical claims by conducting
detailed studies on exploring various phytocannabinoids regarding medicinal use through in vitro
and in vivo activities and the way forward for its commercial utilization.
Spectroscopic Analysis of Nigerian Gem-grade Yellow Garnet Varieties and their Color Differences
Authors: Li Ming , Li Kun , Chen Lingxia , Yu Shengqiang , Fang Qian 
Published: September 2024

Background:
Research on yellow garnets of different shades regarding their varieties,
colors, as well as chemical states, and contents of coloring ions is somewhat lacking. Spectroscopic
analyses are expected to enrich the research methods and data on yellow garnets and explore a scientific
path for enhancing their colors.

Methods:
A series of analyses, such as X-ray diffraction, infrared spectroscopy, ultraviolet-visible
spectroscopy, X-ray photoelectron spectroscopy, and electron microprobe analyses, have been performed
on the garnet crystal samples.

Results:
X-ray diffraction analysis and infrared spectral analysis have shown yellow and tawny garnets
to be spessartite garnets; UV–visible spectral analysis has shown the yellow sample to have
stronger absorption peaks at 408, 421, and 430 nm than the tawny sample. Electron microprobe and
X-ray photoelectron spectroscopy analyses have shown both spessartite garnet samples to contain the
same elements, including Si, O, Al, Ca, Mn, and Fe. Among them, the coloring elements, Mn and Fe,
have been found to be identical in terms of type, chemical state, lattice occupancy, and coordination
environment, but with different mass percentages.

Conclusion:
The color differences between yellow-shaded spessartite garnets from Nigeria have not
been found to arise from differences in the types of coloring elements, their valance states, or coordination
environments. Instead, the concentration of coloring ions Mn2+ and Fe2+ has been identified
as the crucial factor. Controlling the concentrations is the key scientific direction for improving the
colors of these yellow-toned spessartite garnets.

conclusion:
The color differences between yellow-shaded spessartite garnets from Nigeria do not arise from differences in the types of coloring elements, their valance states, or coordination environments. Instead, the concentration of coloring ions Mn2+and Fe2+ is identified as the crucial factor. Controlling the concentrations is the key scientific direction for improving the colors of these yellow-toned spessartite garnets.
Metal Nanoparticles for Ovarian Cancer Therapy
Authors: Patel Arti , Londhe Swapnali , Saha Sudipta , Patra Chitta Ranjan 
Published: September 2024

Background:
Ovarian cancer is the most fatal gynecological cancer, with the highest death rate because of its late diagnosis and recurrence. Owing to the
inherent drawbacks of conventionally available approaches for ovarian cancer treatment, alternative strategies need to be developed. Recently,
nanotechnology-based drug delivery vehicles (polymer, liposome, dendrimers, etc.) have been extensively used in cancer therapy, especially for
ovarian cancer. Among various nanoformulations, metal nanoparticle-based approaches are widely studied for ovarian cancer treatment as they
offer several advantages, such as high therapeutic output, biocompatibility, non-toxicity, non-inflammatory effects, biodegradability, etc.

Objective:
This review aimed to emphasize the advancement of metal-based nanoformulations for ovarían cancer therapy along with toxicological aspects.

Methods:
The information was gathered from many search engines, such as SciFinder, PubMed, and ScienceDirect, to get coverage of suitable research and
compile relevant data about metal nanoparticles for ovarian cancer treatment.

Results:
Investigating metal nanoparticle-based therapies for the treatment of ovarian cancer provides a new direction for future studies.

Conclusion:
This review highlights the anti-cancer activity of metal nanoformulations for ovarian cancer therapy, recent progress, challenges, and future
perspectives in detail, along with the toxicological aspects.
A Review of the Therapeutical Perspective of Phytochemicals in the Treatment of HIV
Authors: Srivastwa Shubham Kumar , Mehra Anuradha , Sangwan Rekha 
Published: September 2024

Abstract:
HIV/AIDS is one of the most widespread global diseases. It is caused by the human immunodeficiency
virus (HIV), which leads to the development of acquired immunodeficiency syndrome
(AIDS). In AIDS patients, the immune system progressively weakens, making them vulnerable
to various infections and cancers. The virus can be transmitted through the exchange of bodily
fluids such as blood, semen, vaginal fluid, and breast milk, where HIV can be found in both free
virus particles and infected immune cells. Although drug resistance remains a challenge for
HIV/AIDS treatment, researchers are exploring the use of natural substances in the development of
anti-HIV drugs. Clinical trials based on plant-derived compounds are currently being conducted.
Experimental research suggests that plants may have the potential to treat HIV. However, the identification
of active compounds, testing of extracts, and creation of suitable bioassays are all complex
processes. Natural product scientists face the challenge of separating these complicated extracts into
their active components. Various phytochemicals found in Astragalus membranaceus Bunge, Chelidonium
majus L, Combretum molle (R. Br. ex. G. Don.) Engl& Diels, Dittrichiaviscosa (L.) Greuter,
Helichrysum populifolium, Hoodia gordonii (Masson) Sweet ex Decne, and Hypericumperf, have
been investigated pharmacologically and pharmacokinetically. Further research is needed to optimize
formulations and production in accordance with preclinical safety and efficacy studies.
Advancing Epigenetic and Antioxidant Strategies in Natural Therapeutics Against SARS-CoV-2: A Mini Review of Current Innovations and Future
Directions
Authors: Adrianta Ketut Agus , Siada Nyoman Budiartha , Wibawa Agung Ari Chandra , Wardani I.G.A.A Kusuma , Shantini Suena Ni Made Dharma 
Published: September 2024

Abstract:
This review explores the potential of natural products, particularly curcumin and gingerol,
as immune regulators and anti-inflammatory agents in combating SARS-CoV-2 infections via epigenetic
and antioxidant mechanisms. Oxidative stress induced by coronavirus infections can trigger
severe immune responses, such as cytokine storms, often leading to therapy failure. This oxidative
stress is exacerbated by depleted antioxidant defenses. The review examines how natural ingredients
activate endogenous antioxidants through pathways like nuclear factor erythroid 2-related factor 2
(Nrf-2) activation, leading to gene expression changes without altering DNA structure. These changes
enhance cellular defenses against oxidative stress and reduce inflammation, potentially mitigating
the virus's effects. The methodology involved a literature review of scientific articles from databases
such as Google Scholar, Elsevier, Science Direct, Scopus, and Wiley Online Library, focusing on
publications from 2010 to 2023. Data were analyzed using deductive qualitative descriptive techniques,
emphasizing the role of natural compounds in activating antioxidant responses to prevent or
minimize cellular damage caused by COVID-19. The review underscores the significant role of diet
and nutritional intake in supporting the body's antioxidant capacity by activating specific receptors
that influence gene expression related to immune responses and cellular repair mechanisms. Flavonoids
and anthocyanins are highlighted as key compounds in natural products with therapeutic potential
against COVID-19. Overall, this research advocates for further exploration of natural products as
viable options for preventing and treating COVID-19, suggesting that these compounds offer dual
benefits of antiviral activity and immune modulation through epigenetic regulation and antioxidant
support.
Phyto-Active Components Delivered through Lipid Nanodrug Carriers as a Promising Avenue for the Treatment of Alzheimer’s Disease: Their Present Status and Industrial Viability
Authors: Mishra Mr. Abhishek , Sahu Pratap Kumar , Satapathy Bhabani Sankar , Biswal Biswabhusan 
Published: September 2024

Introduction:
Present years have witnessed an unprecedented growth of Alzheimer’s
disease (AD) with limited scope for conventional therapeutics. Plant-derived active components
(PACs) are being widely utilized as alternate, compatible, efficacious, eco-friendly strategies to
ameliorate therapeutic benefits in AD while minimizing toxic effects. However, delivery of PACs
in the regular dosage form often faces challenges due to low stability and bioavailability, brainspecific
delivery, dose-related toxic effects, etc., which can be subsided by experimentally fabricated
Lipid Nano Drug Carriers (LNCs). The objective of this study is to provide a comprehensive,
evidence-based review on recent progress in the PACs-loaded lipid nanocarriers (PLNs)-based
therapeutic strategies for AD.

Methods:
For the study implementation, a systematic literature review was carried out from various
scientific potential databases like Scopus, Pubmed, Web of Science, etc., and relevant evidence-
based pre-clinical research data was pooled to draw conclusive outcomes.

Results:
LNCs are treated as promising avenues to effectively deliver various PACs into the brain
due to their high lipophilicity with ultra-micron size and tunable surface features, which make
them eligible to pass through the blood-brain barrier. Both passive and active targeting of PLNs
has been explored to target AD by overcoming the off-target bio delivery problems.

Conclusion:
The review provided updated preclinical study-based data on the potentialities of
PLNs in overcoming AD. Simultaneously, equal weightage was devoted to the issues faced beyond
the laboratory in their successful technology transfer. The study would be beneficial in unveiling
important insights into the implications of PLNs for their futuristic clinical applicability.
A Mini Review on the Opportunities for Membrane Pervaporation Technology for Energy-efficient Removal of Dispersed Oil and Dissolved Hydrocarbons from Produced Water
Authors: Adewole Jimoh K. , Yeneneh Anteneh M. , Oladipo Habeebllah B. , Al Kharusi Asma S.K. 
Published: September 2024

:
Produced water is reported to have the largest volume of waste stream associated
with hydrocarbon recovery. It was estimated to increase from 250 million B/D in 2007
to more than 300 million B/D between 2010 and 2012. Market research conducted by
Adroit put the globally produced water treatment market at a value of USD 5.10 billion in
2022. This value is anticipated to be USD 9.80 billion in 2032 at a compound annual
growth rate (CAGR) of 5.80% over the prediction period. Oil and gas companies have
been mandated to comply with the newly enacted environmental regulations that require
extensive treatment of this water before discharge or reuse. The limited quantity of freshwater
resources coupled with the increasing oil and gas production activities has made it
necessary for all stakeholders to look for sustainable management of this water. Presently,
a certain percentage of produced water is reused while the rest is discharged into the ocean.
In both cases, the water needs to be thoroughly treated. The choice of technologies for produced
water treatment depends on numerous factors, such as the chemical composition of
the water and the level of purity that must be attained before disposal, recycling, or re-use.
Some of the technologies used for produced water treatment include physical separation
methods such as gravity, adsorption, filtration, coalescence, cyclones, flotation, centrifuges,
membranes, and oxidation. There are also chemical and biological separation methods.
Contaminants such as small droplets of dispersed oil and dissolved hydrocarbons
(DODHs) are very challenging to remove using the above-listed water treatment technologies.
Moreover, the use of membrane technology has been limited only to the use of reverse
osmosis and membrane filtration for removing salinity, metals, and other inorganics.
This article highlights the opportunities for the use of membrane vapor permeation and
pervaporation for the removal of the small droplets of DODHs, which have been reported
to be very challenging contaminants to remove. The use of 3D printing technology for the
fabrication of membrane materials was reviewed. The 3D membrane development method
can be used to fabricate almost any shape of the material in a highly customized manner
using computer-aided design. The information presented in this article will serve as a useful
reference for the technologies used for a sustainable water treatment strategy in the oil
and gas industry.
Parametric Investigation of Rotary Type Magnetorheological Finishing
Operation by Batch Gradient Descent Algorithm
Authors: Singh Manpreet 
Published: September 2024

Background:
The consistency of the magnetorheological process insisted that the
Inconel® 718 material should be furnished. This process involves every material from the categories of soft and hard materials.

Aim:
In this study, a cylindrical ferromagnetic work-part was finished using the
magnetorheological finishing method.

Objective:
The strength of the magnetic flux controls the density and forces in processes that
are assisted by magnetic fields. The mechanism was studied parametrically in this research
work using response surface methodology

Methods:
Optimal process parameters were determined using response surface methodology to
accurately execute the finishing procedure. Each parameter's percentage consumption to the
process's finishing output was also estimated. The finishing of an industrial extrusion punch
was carried out using the optimum parameters obtained from the parametric analysis.

Results:
The RSM optimisation of process parameters is validated using the batch gradient
descent (BGD) algorithm which is the best fit and innovation algorithm for these types of
optimization solutions. The mathematical model that BGD provides confirms the RSM
mathematical model.

Conclusion:
The optimized parameters are useful in controlling the capability of the MR finishing process in various industrial applications.
Pengaruh Manajemen Modal Kerja Terhadap Profitabilitas Perusahaan
Authors: Nabella Efryca Ayu , Djazuli Atim 
Published: September 2024

The importance of working capital management is observable from its role of measuring success and increasing profits. The objective of this research is to identify the effects of working capital management on the profitability of food-and-beverage companies listed on the Indonesia Stock Exchange during the 2018-2022 period. The working capital was measured using inventory conversion period, average collection period, and payables deferral period, while the profitability was measures using return on assets. Using saturated sampling, all 20 companies were included as the sample. The data was analyzed using multiple linear regression in SPSS version 27. This study finds that inventory conversion period, average collection period, and payables deferral period simultaneously have significant effects on the companies’ return on assets. In partial, only does payables deferral period positively and significantly influence the return on assets. This means that the longer the payables deferral period, the higher the profitability because the companies can use the available find to invest in other sectors to increase the chance of attaining a higher profitability. Further, inventory conversion period and average collection period do not significantly influence return on assets. This is an indication that there is no correlation between the duration or the swiftness of inventory conversion period and average collection period and the companies’ profitability.

Abstrak
Pentingnya manajemen modal kerja dapat dilihat dari peranannya untuk mengukur keberhasilan dalam meningkatkan laba. Penelitian ini, bertujuan untuk mengetahui pengaruh manajemen modal kerja terhadap profitabilitas perusahaan-perusahaan Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia tahun 2018-2022. Modal kerja diukur menggunakan periode konversi persediaan, periode penerimaan rata-rata, dan periode penangguhan utang, sedangkan profitabilitas diukur dengan Return on Asset. Pengambilan sampel dilakukan dengan teknik sampel jenuh, sehingga didapatkan sampel berjumlah 20 perusahaan. Data diolah dengan menggunakan metode analisis regresi liner berganda menggunakan SPSS versi 27. Hasil penelitian menunjukkan bahwa periode persediaan, periode penerimaan rata-rata, dan periode penangguhan utang berpengaruh signifikan secara simultan terhadap Return on Asset perusahaan. Secara parsial, hanya periode penangguhan utang yang memiliki pengaruh signifikan positif terhadap Return on Asset. Artinya, semakin lama periode penangguhan utang dapat meningkatkan profitabilitas, karena perusahaan dapat menggunakan dana yang tersedia untuk berinvestasi di sektor lain terlebih dahulu untuk memperbesar peluang dalam mencapai profitabilitas yang lebih tinggi. Periode konversi persediaan dan periode penerimaan rata-rata tidak berpengaruh signifikan terhadap Return on Asset. Hal ini berarti tidak ada korelasi antara durasi atau kecepatan periode konversi persediaan dan penerimaan rata-rata dengan tingkat profitabilitas perusahaan.
Optimasi Program Linear Bilangan Fuzzy Linear pada Studi Kasus Produksi Beton UD. Benteng Sanjaya Prambanan
Authors: Rahmawati Dewi , Karyati Karyati 
Published: September 2024

Tujuan dari penelitian ini adalah membahas proses penyelesaian Model Program Linear Fuzzy (MPLF) dengan koefisien teknis dan koefisien ruas kanan berbentuk bilangan fuzzy linear turun dan aplikasinya pada masalah optimasi laba UD. Benteng Sanjaya Prambanan untuk menentukan produksi batako, genteng dan paving sehingga diperoleh laba yang optimal diselesaikan dengan metode fuzzy subgradien dan bantuan software Linggo 11.0. MPLF, membentuk fungsi keanggotaan fuzzy goal dan fuzzy constraints dari model MPLF kemudian diiriskan untuk menghasilkan peyelesaian optimal pada fuzzy decision, membentuk MPL dengan menggunakan parameter dan menyelesaikan MPL dengan metode fuzzy subgradien yang digunakan untuk menghasilkan nilai yang terbesar sehingga diperoleh solusi yang layak optimal. Hasil perhitungan dari aplikasi Linggo 11.0 pada masalah optimasi laba UD. Benteng Sanjaya Prambanan yaitu batako sebanyak 0 kali produksi, genteng sebanyak 13 kali produksi, dan paving sebanyak 26 kali produksi sehingga mendapatkan laba sebanyak Rp.1.352.000,00 per hari.
MODEL MATEMATIKA DARI DINAMIKA KECANDUAN MEDIA SOSIAL TIKTOK PADA MAHASISWA UNIVERSITAS NEGERI YOGYAKARTA ANGKATAN 2019
Authors: Firdaus Karin Annisa , Krisnawan Kus Prihantoso 
Published: September 2024

Abstrak Penelitian ini bertujuan untuk mengetahui model matematika dari dinamika kecanduan media sosial TikTok pada mahasiswa Universitas Negeri Yogyakarta (UNY) angkatan 2019 dan menggunakan model tersebut untuk memprediksi dinamika kecanduan selama 1 tahun ke depan. Penelitian dilakukan dengan menggunakan pemodelan matematika SA1A2R (Susceptible Addicted 1, Addicted 2, Recoverred) yang merupakan adaptasi dari model epidemi SIR (Susceptible Infected Recovered). Simulasi dari model dibandingkan dengan kondisi saat ini dan jika tidak terdapat kesesuaian di antara keduanya maka model akan direvisi. Kondisi saat ini diperoleh dari data yang dijaring menggunakan Google form. Info mengenai link Google form disebarluaskan secara khusus kepada mahasiswa UNY angkatan 2019. Hasil penelitian menunjukkan bahwa model berupa sistem persamaan diferensial nonlinier berdimensi 4 dengan 4 titik ekuilibrium. Berdasarkan hasil simulasi model, dapat diketahui bahwa tingkat kecanduan 2 saat ini hingga 1 tahun yang akan datang jauh lebih tinggi daripada tingkat kecanduan 1. Sedangkan berdasar analisis kestabilan titik ekuilibrium dapat diketahui bahwa kedua jenis kecanduan bergerak menuju ke 0.