bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants
Authors: Ducos Eric , Vergès Valentin , Dugé de Bernonville Thomas , Blanc Nathalie , Giglioli-Guivarc’h Nathalie , Dutilleul Christelle 
Published: June 2017

AbstractDucos et al. report that the farnesylated protein ASG2 is the Arabidopsis ortholog of human WDCT1, which controls fat accumulation. Both proteins harbor..ASG2 (Altered Seed Germination 2) is a prenylated protein in Arabidopsis thaliana that participates to abscisic acid signaling and is proposed to act as a substrate adaptor for the DDB1 (DNA damage-binding protein 1)-CUL4 (Cullin 4) E3 ubiquitin ligase complex. ASG2 harbors WD40 and TetratricoPeptide Repeat (TPR) domains, and resembles the well-conserved animal gene called ADP (antiobesity factor ADIPOSE) in fly and WDTC1 (WD40 and TPR 1) in humans. Loss of function of WDTC1 results in an increase in adipocytes, fat accumulation, and obesity. Antiadipogenic functions of WDTC1 involve regulation of fat-related gene transcription, notably through its binding to histone deacetylases (HDACs). Our sequence and phylogenetic analysis reveals that ASG2 belongs to the ADP/WDTC1 cluster. ASG2 and WDTC1 share a highly conserved organization that encompasses structural and functional motifs: seven WD40 domains and WD40 hotspot-related residues, three TPR protein–protein interaction domains, DDB1-binding elements [H-box and DWD (DDB1-binding WD40 protein)-box], and a prenylatable C-terminus. Furthermore, ASG2 involvement in fat metabolism was confirmed by reverse genetic approaches using asg2 knockout Arabidopsis plants. Under limited irradiance, asg2 mutants produce “obese” seeds characterized by increased weight, oil body density, and higher fatty acid contents. In addition, considering some ASG2- and WDTC1-peculiar properties, we show that the WDTC1 C-terminus is prenylated in vitro and HDAC-binding capability is conserved in ASG2, suggesting that the regulation mechanism and targets of ADP/WDTC1-like proteins may be conserved features. Our findings reveal the remarkable evolutionary conservation of the structure and the physiological role of ADIPOSE homologs in animals and plants.
Appendiceal Mucinous Neoplasms: Diagnosis and Management
Authors: Shaib Walid L. , Assi Rita , Shamseddine Ali , Alese Olatunji B. , Staley Charles , Memis Bahar , Adsay Volkan , Bekaii-Saab Tanios , El-Rayes Bassel F. 
Published: June 2017

Abstract

Objective
Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs.

Methods and Review Criteria
We conducted a PubMed search in February 2016 for English-language publications, using the terms “appendiceal,” “appendix,” “carcinoma,” “cancer,” “mucinous,” “treatment,” “genes,” “target,” “genomic,” and terms listed in the articles' subheadings. Published reports and abstracts from the American Society of Clinical Oncology meetings were also searched.

Results
In this review, we summarize current data and controversies in AMN classification, clinical presentation, molecular alterations, treatment outcomes with regard to cytoreductive surgery, hyperthermic intraperitoneal chemotherapy (HIPEC), and the role of systemic chemotherapy.

Conclusion
Appendiceal mucinous neoplasms are a heterogeneous group of tumors with a rising incidence. Treatment is based on stage and histology. Low-grade tumors are treated surgically with resection of the primary site in early stage disease, or peritoneal debulking and HIPEC in patients with advanced stage disease. Treatment of high-grade tumors requires further prospective trials, and options include debulking surgery and HIPEC with or without preoperative chemotherapy. Trials evaluating novel therapies based on the molecular profiling of AMN tumors are needed to evaluate therapeutic options in patients who are not surgical candidates.
Replacement names for bees in the tribe Megachilini (Hymenoptera: Megachilidae)
Authors: Engel Michael S. 
Published: June 2017

Eight instances of homonymy are identified in the megachiline genera Coelioxys Latreille and Megachile Latreille, with replacement names established for the junior homonyms. Coelioxys (Coelioxys) lethosyne Engel, new name, is proposed for C. simplex latefasciata Friese (nec Morawitz); C. (Liothyrapis) wuae Engel, new name, is proposed for C. albofasciata Wu (nec Radoszkowski); Megachile (Eutricharaea) hisarica Engel, new name, is proposed for M. dentata Rahman & Chopra (nec Friese); M. (Megachile) agnosta Engel, new name, is proposed for M. japonica Matsumura (nec Alfken); M. (Dasymegachile) schwimmeri Engel, new name, is proposed for M. mitchelli Raw (nec Gupta); M. (Creightonella) taftanica Engel, new name, is proposed for M. aurantiaca Rebmann (nec Friese); M. (Callomegachile) biseta austrina Engel, new name, is proposed for M. biseta australis Pasteels (nec Lucas); and M. (C.) ceratops Engel, new name, is proposed for M. monoceros Friese (nec Pallas).
Congenital dislocation of the knee: prenatal diagnostics and treatment at an early age
Authors: Rumyantsev Nicolai Y. , Kruglov Igor Y. , Omarov Gamzat G. , Voronin Dmitry V. , Rumiantceva Natalia N. 
Published: June 2017

Background. Congenital dislocation of the knee (CDK) is a rare abnormality of the musculoskeletal system, with an incidence of 1 per 100,000 liveborn infants. Timely prenatal diagnostics and treatment during the initial days of life can help avoid the development of disabilities in a child.
Aim of the study. We aimed to study the possible prenatal ultrasound diagnostics and to assess the efficacy of early orthopedic alignment using conservative methods of treatment.
Materials and methods. From January 1988 to February 2016, 37 newborns (50 lower limbs) with CDK were treated. The initial assessment of the affected limbs was performed immediately after birth. To determine the severity of dislocation, the Seringe and Tarek classifications were used. Conservative treatment was performed for all the patients. The age of pediatric patients at the time of treatment onset ranged from 2 hours to 5 days. Various methods were used, such as stage plaster bandages (10 lower limbs) and correction using the von Rosen splint (8 lower limbs). Since 2003, a single treatment protocol, developed by the authors of this study, has been applied.
Results. The prenatal ultrasound screening enabled the detection of CDK before birth in 21% of cases. Long-term results (catamnesis from 3 to 28 years) were evaluated by the Seringe scale and were excellent in 60%, good in 32%, and satisfactory in 8% of cases. Bad results were not registered. All the pediatric patients included in the study began to walk independently at the age of 9–18 months.
Conclusion. Prenatal ultrasound diagnosis enables the detection of CDK. Treatment of newborns, started in the first hours of life, according to the protocol developed by the authors, enables the alignment of the dislocated lower leg in a short time, without using prolonged stage plaster bandages. Long-term results demonstrate the efficiency of the proposed methodology.
Effects of salinity stress on chickpea (Cicer arietinum L.) landraces during early growth stage
Authors: Zawude Seyoum , Shanko Diriba 
Published: June 2017

<p class="abstract"><strong>Background:</strong> Salinity is one of the most serious abiotic stresses for crop plant growth. Chickpea grows under a wide range of climatic conditions and highly sensitive to salt stress. To determine the most tolerant genotype to salinity stress, an experiment was done as factorial form under completely block design (CRD) with three replications.</p><p class="abstract"><strong>Methods:</strong> The experimental treatments were four NaCl salinity levels (0, 5dS/m, 10dS/m and 15dS/m) and five chickpea landraces (Dadi, Dido, Dida, Dimi and Soya). </p><p class="abstract"><strong>Results:</strong> Results indicated that significant was observed in root length, shoot length, shoot fresh weight, root fresh weight, shoot dry weight, root dry weight, seedling shoot and root reduction traits in stress conditions. Dimi, Dido and Dadi were showed that high reduction in root length, shoot length, root length, shoot fresh weight, root fresh weight, shoot dry weight, root dry weight, seedling root and shoot in salinity conditions, respectively. The ANOVA for landraces and their interaction was found to be highly significant at (p&lt;0.001) and (p&lt;0.05) with all parameters. Landraces Dimi, Dido and Dadi were found salt tolerant but Soya was highly salt sensitive during seedling growth stage. Shoot dry weight had the most positive and significant correlation with root dry weight (r =0.987**). Seedling shoot reduction depicted a negative and significant correlation with total dry matter (r =-0.734**).</p><strong>Conclusions:</strong> This study indicated that developing genetic variability by identifying salt tolerant landrace is one of the appropriate strategies used to overcome salinity problem in arid and semi-arid areas.
Beyond US-Centered Multicultural Foundations on Race
Authors: Jupp James C. , Espinosa-Dulanto Miryam 
Published: June 2017

Our conceptual essay begins with the recognition of the U.S. racialized tragedy and embattled discussions on race. Within this tragedy and embattled discussion, we attempt to renew and reinvigorate authentic, dialogic, and vulnerable exchanges on race. With this focus, we critique yet further advance multicultural foundations’ notions of racial identity predominant in the academy and in broader national discussions on race. Critiquing yet advancing multicultural foundations, we emphasize conceptual content from five books on race and power by Cornel West. Working through West’s conceptual content, we emphasize complex and historicized identifications and relationalities as key concepts in the present moment.
Special Issue on the 2016 Kumamoto Earthquakes
Authors: Hayashi Haruo 
Published: June 2017

At 9:26 pm on April 14, 2016, a magnitude 6.5 earthquake struck directly beneath Kumamoto prefecture, Japan, producing a seismic intensity level (JMA) of 7 in Mashiki Town. Although the earthquake damage forecasting system in operation at the time predicted that this earthquake would cause no damage, it resulted in extensive human casualties and property damage centered in Mashiki Town. Past midnight on April 16, 28 hours after the first shock, the second and main shock hit, which recorded magnitude 7.3 and was the strongest recorded urban earthquake in Japan since 1995. The hypocenter extended from Kumamoto prefecture to Oita prefecture, cutting across the island of Kyushu. Mount Aso also saw increased volcanic activities which led to several landslides. This resulted in the collapse of the Great Aso Bridge, an important transportation point, causing the loss of human lives as well as obstruction of traffic for an extended period. Much confusion arose in the process of implementing measures in response to the earthquakes, which produced damage in urban areas as well as hilly and mountainous regions, raising many issues and prompting several new approaches. Researchers in many fields have conducted various activities at the disaster sites in the one-year period following the earthquakes, and produced significant findings in many areas. In order to make these results available to the wider global community, JDR is releasing a special issue on the 2016 Kumamoto Earthquakes with excellent papers and reports to mark their one-year anniversary. While the submitted papers to this special issue went through our regular peer review process, no publication charge was imposed so as to encourage as many submissions as possible.
It is our hope that this special issue will contribute to throwing light on the 2016 Kumamoto Earthquakes in its entirety.
Combined application of low intensity pulsed ultrasound in dental implantation
Authors: Bubulis A. , Rubnikovich S. , Khomich I. , Denisova Y. , Minchenya Vl. 
Published: June 2017

To study the effect of to low-intensity low frequency pulsed ultrasound (LILFPUS) on the surface wettability of titanium dental implants, an experimental medical-technical model was developed, consisting of an ultrasonic device, a fixed-mounted digital photo/video camera and a laboratory stand with a smooth vertical feed, in which an ultrasound nozzle with an experimental dental implant and fastener with a control implant were fixed. As a wetting agent, 0.9 % sterile physiological sodium chloride solution was used in a petri dish tinted with brilliant green. Using the components of the model, it was possible to immerse the control and experimental dental implants, fixed on a laboratory stand, equally and uniformly at the same depth. The results of the studies showed that under the influence of ultrasound, the wetting of the surface of all the test samples was 100 %, and the wetting of the control samples was not observed.
A piezoelectric motor driven by a single-phase signal
Authors: Li Chong , Lu Cun-Yue , Ma Yi-Xin 
Published: June 2017

This paper aims to present a proof-of-concept for a novel piezoelectric motor using a single-phase driving signal. The stator is constructed by bonding a Terfenol-D plate and a piezoelectric ceramic (PZT) plate onto the outer surface of a metal base. The PZT plate based on d31 effect is used to simultaneously excite two in-plane bending modes of the stator. Similarly, the Terfenol-D plate can also be used to excite the two bending modes. By superposition of the two bending modes, elliptical motions of the stator surface points are generated. The working modes and vibration characteristics of the motor are analyzed by finite element analysis software. The resonance frequencies of the two bending modes are tuned to be close by additional mass. The dimensions of the stator are optimized to maximize the output displacement. To confirm the feasibility of the proposed design, a prototype motor is fabricated and tested. The size of the prototype motor is about 11.2×10.7×28.0 mm3. The tested resonance frequencies of the two bending modes are 16.0820 kHz and 16.3476 kHz respectively. The maximum no-load speed is 85 rpm. The applied driving voltage is 100 Vo-p (peak voltage) at a frequency of 16.34 kHz.
A Review of the Management of Lymphangiomas
Authors: Ha Jennifer , Yu Yu-Ching , Lannigan Francis 
Published: June 2017

Introduction:
Lymphangioma is a rare benign cyst caused by congenital malformation of the lymphatic systems that often occurs in the cervicofacial region. There is no consensus on its management: Observation, aspiration, injection, cryotherapy, electrocautery, radiation, laser, ligation and excision.

Methods:
We performed a literature search with the keywords “cystic hygroma”, “lymphangioma”, “management”, “OK 432” and “picibanil” from Medline, Embase and PubMed databases.

Results:
We present a review of the history, signs and symptoms, diagnosis, histology, classification and management options of cystic hygroma.

Conclusion:
There is no consensus on the treatment options. It should be individualised depending on the size of the lesion, anatomic localisation and complications.
My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety
Authors: Johnson Suzanne Bennett , Lynch Kristian F. , Roth Roswith , Schatz Desmond ,   the TEDDY Study Group
Published: June 2017

OBJECTIVE
To assess parent anxiety in response to genetic and islet autoantibody (IA) testing in children at increased genetic risk for type 1 diabetes followed from birth in The Environmental Determinants of Diabetes in the Young (TEDDY) study.

RESEARCH DESIGN AND METHODS
Parent anxiety about TEDDY children’s risk was assessed with the State Anxiety Inventory (SAI). Parents completed the SAI when the child was 3, 6, and 15 months old and annually thereafter. Children were tested for IA every 3 months for 4 years and every 6 months thereafter. Parent SAI scores of 6,799 children followed with IA testing for at least 1 and up to 6 years were examined.

RESULTS
At study inception, parents showed high levels of anxiety in response to their child’s increased genetic type 1 diabetes risk; mothers were more anxious than fathers, and parents with diabetes in the family were more anxious than parents with no family history. In response to repeated IA-negative (IA−) test results, parent anxiety declined to normal levels. Anxiety increased in parents faced with an IA-positive (IA+) test result. Parents faced with two or more types of IA+ test results showed particularly high levels of anxiety (all P &lt; 0.001).

CONCLUSIONS
Infant genetic screening for type 1 diabetes raises parent anxiety when the child is at increased risk, but anxiety dissipates over time in cases of repeated IA− results. IA+ results heighten parent anxiety, and parents faced with two or more types of IA+ results may experience considerable anxiety for longer periods.
Shunt-dependent hydrocephalus: management style among members of the American Society of Pediatric Neurosurgeons
Authors: Kraemer Mark R. , Sandoval-Garcia Carolina , Bragg Taryn , Iskandar Bermans J. 
Published: June 2017

OBJECTIVEThe authors conducted a survey to evaluate differences in the understanding and management of shunt-dependent hydrocephalus among members of the American Society of Pediatric Neurosurgeons (ASPN).METHODSSurveys were sent to all 204 active ASPN members in September 2014. One hundred thirty responses were received, representing a 64% response rate. Respondents were asked 13 multiple-choice and free-response questions regarding 4 fundamental problems encountered in shunted-hydrocephalus management: shunt malfunction, chronic cerebrospinal fluid (CSF) overdrainage, chronic headaches, and slit ventricle syndrome (SVS).RESULTSRespondents agreed that shunt malfunction occurs most often as the result of ventricular catheter obstruction. Despite contrary evidence in the literature, most respondents (66%) also believed that choroid plexus is the tissue most often found in obstructed proximal catheters. However, free-text responses revealed that the respondents’ understanding of the underlying pathophysiology of shunt obstruction was highly variable and included growth, migration, or adherence of choroid plexus, CSF debris, catheter position, inflammatory processes, and CSF overdrainage. Most respondents considered chronic CSF overdrainage to be a rare complication of shunting in their practice and reported wide variation in treatment protocols. Moreover, despite a lack of evidence in the literature, most respondents attributed chronic headaches in shunt patients to medical reasons (for example, migraines, tension). Accordingly, most respondents managed headaches with reassurance and/or referral to pain clinics. Lastly, there were variable opinions on the etiology of slit ventricle syndrome (SVS), which included early shunting, chronic overdrainage, and/or loss of brain compliance. Beyond shunt revision, respondents reported divergent SVS treatment preferences.CONCLUSIONSThe survey shows that there is wide variability in the understanding and management of shunt-dependent hydrocephalus and its complications. Such discrepancies appear to be derived partly from inconsistent familiarity with existing literature but especially from a paucity of high-quality publications.
A SOFIA FORCAST Grism Study of the Mineralogy of Dust in the Winds of Proto-planetary Nebulae: RV Tauri Stars and SRd Variables
Authors: Arneson R. A. , Gehrz R. D. , Woodward C. E. , Helton L. A. , Shenoy D. , Evans A. , Keller L. D. , Hinkle K. H. , Jura M. , Lebzelter T. , Lisse C. M. , Rushton M. T. , Mizrachi J. 
Published: June 2017

Abstract
We present a SOFIA FORCAST grism spectroscopic survey to examine the mineralogy of the circumstellar dust in a sample of post-asymptotic giant branch (post-AGB) yellow supergiants that are believed to be the precursors of planetary nebulae. Our mineralogical model of each star indicates the presence of both carbon-rich and oxygen-rich dust species—contrary to simple dredge-up models—with a majority of the dust in the form of amorphous carbon and graphite. The oxygen-rich dust is primarily in the form of amorphous silicates. The spectra do not exhibit any prominent crystalline silicate emission features. For most of the systems, our analysis suggests that the grains are relatively large and have undergone significant processing, supporting the hypothesis that the dust is confined to a Keplerian disk and that we are viewing the heavily processed, central regions of the disk from a nearly face-on orientation. These results help to determine the physical properties of the post-AGB circumstellar environment and to constrain models of post-AGB mass loss and planetary nebula formation.
Solar Overshoot Region and Small-scale Dynamo with Realistic Energy Flux
Authors: Hotta H. 
Published: June 2017

Abstract
We carry out high-resolution calculations of the solar overshoot region with unprecedentedly realistic parameters, especially the small energy flux compared with

, where ρ and c
s are density and speed of sound. Our main purpose is to investigate the behavior of the overshoot and the small-scale dynamo with parameters as close as possible to those of the Sun. Our calculations show that the bottom part of the convection zone (CZ) becomes subadiabatic, which efficiently suppresses downflows. As a result, we see a steep transition from the CZ to the radiative zone, whose width is estimated to be 0.4% of the local pressure scale height. This result is consistent with a semianalytic convection/overshoot model. We also find that the small-scale dynamo becomes efficient with a smaller energy flux. The sudden suppression of the downflows around the base of the CZ increases the efficiency of the small-scale dynamo.
In-silico based identification and functional analyses of miRNAs and their targets in Cowpea (Vigna unguiculata L.)
Authors: Gul Zareen , Barozai Muhammad Younas Khan , Din Muhammad 
Published: June 2017

AbstractCowpea (Vigna unguiculata L.) is an important leguminous plant and a good diet due to presence of carbohydrate and high protein contents. Currently, only few cowpea microRNAs (miRNAs) are reported. This study is intended to identify and functionally analyze new miRNAs and their targets in cowpea. An in-silico based homology search approach was applied and a total of 46 new miRNAs belonging to 45 families were identified and functionally annotated from the cowpea expressed sequence tags (ESTs). All these potential miRNAs are reported here for the first time in cowpea. The 46 new miRNAs were also observed with stable hairpin structures with minimum free energy, ranging from −10 to −132 kcal mol−1 with an average of −40 kcal mol−1. The length of new cowpea miRNAs are ranged from 18 to 26 nt with an average of 21 nt. The cowpea miRNA-vun-mir4414, is found as pre-miRNA cluster for the first time in cowpea. Furthermore, a set of 138 protein targets were also identified for these newly identified 46 cowpea miRNAs. These targets have significant role in various biological processes, like metabolism, transcription regulation as transcription factor, cell transport, signal transduction, growth & development and structural proteins. These findings are the significant basis to utilize and manage this important leguminous plant-cowpea for better nutritional properties and tolerance for biotic and abiotic stresses.