bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do green policies achieve the carbon neutrality target? Revealing the effectiveness of environmental innovation
Authors: Xian Xiang , Wu Jiang , Huang Mei , Mou Qiuping 
Published: October 2024

AbstractIn recent decades, the Environmental policy and environmental innovation are becoming the central policy instruments aimed at carbon neutrality. This empirical study scrutinizes the role of environmental policy and eco‐innovation on CO2 emissions for G7 countries. The study employs second‐generation panel data econometric methods along with panel quantile regression spanning from 1990 to 2019. The empirical findings infer that environmental policy and eco‐innovation significantly mitigate CO2 emissions in the long run. While, panel quantile regression also infers that environmental policy is negatively significant in all quantiles, but eco‐innovation is negatively significant from the 40th to 70th quantiles and insignificant in all other quantiles. The estimated results may further reinforce the policymakers in G7 countries on the promotion of green policy and eco‐innovation in carbon neutrality targets.
Flagellate bacteria‐mediated tumour antigen delivery: A novel approach to enhance dendritic cell activation for in situ cancer vaccination
Authors: Xia Wen , Wu Jinhui 
Published: October 2024

AbstractIn situ vaccination is a therapeutic approach aimed at exploiting tumour antigens available at a tumour site to induce tumour‐specific adaptive immune responses. Antigens released from dying tumour cells are assumed to be taken up by activated dendritic cells and presented to T cells that seek out and destroy tumour cells. This process is significantly impeded in the immunosuppressive microenvironment of tumours. There is a growing trend in in situ vaccine strategies that utilize bacteria as natural adjuvants or as factories for cytokines, aiming to enhance the presentation of in situ antigens by antigen‐presenting cells. Recently, a novel approach using flagellate bacteria‐mediated antigen delivery to activate dendritic cells has been proposed. This method actively facilitates the delivery of intratumoral antigens, improving their presentation for in situ cancer vaccination. Here, we highlight how flagellate bacteria‐mediated antigen delivery enhances the immune activation capabilities of in situ vaccines. Meanwhile, we provide perspectives and outlooks on these promising antigen delivery technologies.
Effect of Aspect and Elevation on the Degree of Aggregation and the Functional Traits in Phlomis floccosa D. Don (Lamiacae) Populations
Authors: Al Borki Abd El‐Nasser S. , Alzerbi Abdulhamid K. , Kabiel Hanan F. , Hegazy Ahmad K. 
Published: October 2024

ABSTRACTPhlomis floccosa D. Don populations are distributed in different microhabitats within Al‐Akhdar mountainous landscape, in Libya. Five populations were selected for the study. Spatial relationships among individuals were investigated using the spatial point pattern analysis. Functional traits were recorded at the vegetative, flowering and fruiting stages. Seeds were collected at the dispersal stage to estimate the regeneration potential. Greater degree of aggregation was found at higher elevations on both northern and southern sides of the mountain but with different demography and traits. On the northern side, greater degree of aggregation was accompanied by absence of large adults and greater percentage of seedlings, and it was positively associated with the reproductive output, while negatively associated with the size and regeneration indices. On the southern side, greater degree of aggregation was accompanied by greater contribution of large adults and greater percentage of seedlings, and it was positively associated with the size and regeneration indices, while negatively associated with the reproductive output. On the other hand, the population in the wadi (valley) microhabitat showed coarse‐scale clumped pattern, higher values for most of the functional traits and higher contribution of seedlings but with lower facilitation offered by adults. The variations in the degree of aggregation and the functional traits trade‐offs in P. floccosa populations ensured successful survival and regeneration in the heterogeneous microhabitats. Meanwhile, stressed conditions greatly affect the survival and regeneration of the species suggesting the need for conservation measures to overcome the adverse effects of climate change.
How African Ungulates Respond to Tourist Vehicles in Kruger National Park
Authors: Romero Andrea , O'Neill Brian J. , Rauch Kristen , Roscoe Ashley 
Published: October 2024

ABSTRACTManagers of protected areas need to balance how they use or preserve their resources, especially regarding ‘road ecology’. This study focuses on Kruger National Park's (KNP) common ungulates’ response to tourist vehicles. We answered the following questions for impala, zebra, giraffe, blue wildebeest, greater kudu and steenbok: What mediates animal flight and flight distance from a vehicle? How much of KNP is affected by roads? Are ungulates using or avoiding roads? We sampled 55.9% of KNP's tourist roads, where we approached animals and determined whether and how far they fled. We georeferenced sightings and estimated the amount of land area along KNP's tourist roads where animals would be expected to flee from vehicles. Of 517 animal sightings, Impala were sighted most (263) and steenbok least (32). Impala had the highest flight propensity (42.6%) and wildebeest lowest (13%). Steenbok were found closest to the road (22.13 m) and wildebeest furthest (77.6 m). Impala had the closest tolerance distance (16.63 m), with zebra furthest (44.74 m). Impala fled the least distance (9.93 m) and zebra fled furthest (24.52 m). Binary logistic regressions (BLRs) showed that all species fled more consistently when closer to the road. The amount of KNP affected by animal flight based on BLRs was largest for zebra (2.32% of the park) and smallest for kudu (0.84%). Impala used the first 10 m of the roadside more than expected and 10–20 m from the road less. KNP's ungulates are habituated to vehicles since flight propensity was low, distribution analysis showed no‐road avoidance, flight distance was short, and animals > 50 m from the road generally do not flee. Given the amount of KNP that is already affected by vehicle traffic, as tourism increases, the land solely devoted to wildlife will necessarily decrease. This study aims to provide information for the best management of roads and traffic in KNP.
Role of Inflammatory Markers and Doppler Parameters in Late‐Onset Fetal Growth Restriction: A Machine‐Learning Approach
Authors: Ulusoy Can Ozan , Kurt Ahmet , Seyhanli Zeynep , Hizli Burak , Bucak Mevlut , Agaoglu Recep Taha , Oguz Yüksel , Yucel Kadriye Yakut 
Published: October 2024

ABSTRACTObjectivesThis study evaluates the association of novel inflammatory markers and Doppler parameters in late‐onset FGR (fetal growth restriction), utilizing a machine‐learning approach to enhance predictive accuracy.Materials and MethodsA retrospective case–control study was conducted at the Department of Perinatology, Ministry of Health Etlik City Hospital, Ankara, from 2023 to 2024. The study included 240 patients between 32 and 37 weeks of gestation, divided equally between patients diagnosed with late‐onset FGR and a control group. We focused on novel inflammatory markers—systemic immune‐inflammation index (SII), systemic inflammatory response index (SIRI), and neutrophil‐percentage‐to‐albumin ratio (NPAR)—and their correlation with Doppler parameters of umbilical and uterine arteries. Machine‐learning algorithms were employed to analyze the data collected, including demographic, neonatal, and clinical parameters, to develop a predictive model for FGR.ResultsThe machine‐learning model, specifically the Random Forest algorithm, effectively integrated the inflammatory markers with Doppler parameters to predict FGR. NPAR showed a significant correlation with FGR presence, providing a robust tool in the predictive model (Accuracy 77%, area under the curve [AUC] 0.851). In contrast, SII and SIRI, while useful, did not achieve the same level of predictive accuracy (Accuracy 75% AUC 0.818 and Accuracy 73% AUC 0.793, respectively). The model highlighted the potential of combining ultrasound measurements with inflammatory markers to improve diagnostic accuracy for late‐onset FGR.ConclusionsThis study illustrates the efficacy of integrating machines with traditional diagnostic methods to enhance the prediction of late‐onset FGR. Further research with a larger cohort is recommended to validate these findings and refine the predictive model, which could lead to improved clinical outcomes for affected pregnancies.Trial RegistrationClinicalTrials.gov identifier: NCT06372938
The more smoking the more cataract: A study on smoking, snus use and cataract in a Swedish population
Authors: Nordström Moa , Zetterberg Madeleine , Torén Kjell , Schiöler Linus , Holm Mathias 
Published: October 2024

AbstractPurposeTo examine the prevalence of self‐reported cataract and cataract surgery, and the incidence of cataract surgery, in relation to smoking and use of the moist smokeless tobacco product snus.MethodsIn 2014/2015, individuals born in 1951 (n = 18 055) in the Västra Götaland County, Sweden, were invited to participate. Of these, 9743 (54%) accepted participation and 9316 (52%) remained after exclusion criteria were applied. Participants answered a questionnaire with items about eye conditions, smoking, snus, gender, education, asthma, chronic obstructive pulmonary disease, corticosteroid use, diabetes mellitus, weight and height. Prevalence ratios (PRs) for self‐reported cataract and cataract surgery were calculated. The incidence of cataract surgery was assessed, and hazard ratios (HRs) were presented.ResultsHaving ever smoked was associated with a higher prevalence ratio of self‐reported cataract (PR 1.19, 95% confidence interval [CI] 1.04–1.35) and cataract surgery (PR 1.27, 95% CI 1.06–1.53), compared to those who had never been daily smokers. Currently, a smoker was associated with a higher HR of cataract surgery (HR 1.34, 95% CI 1.04–1.74), as well as having been a former smoker (HR 1.27, 95% CI 1.03–1.56). Total years of smoking were associated with an increased risk for cataract surgery (HR 1.05, 95% CI 1.02–1.08 for 5 years of smoking). Snus use was not associated with an increased prevalence of cataract or incidence of cataract surgery, except among women who were current snus users (HR for cataract surgery 2.04, 95% CI 1.16–3.60 n = 108).ConclusionSmoking is associated with a higher prevalence of cataracts, and a higher incidence of cataract surgery, indicating a dose–response relationship. However, there was no firm association between snus use and cataract.
The effects of corporate social responsibility on member loyalty: The mediating effect of psychological ownership and customer citizenship behaviour in Korean consumer cooperatives
Authors: Kim Sunhwa , Kim Ahyoung , Huh Kwangjin , Park Sangsun 
Published: October 2024

AbstractThis paper aims to elucidate the relationship between members' perceptions of corporate social responsibility (CSR) within consumer cooperatives, their loyalty towards the cooperatives and the mediating roles of psychological ownership and consumer citizenship behaviour. A sample comprising 773 members of four Korean consumer cooperative federations was constructed and analysed using the structural equation model. In Korea, consumer cooperatives have developed a production and distribution network for eco‐friendly organic agricultural products. In addition, they have grown by practicing social responsibility as a primary organizational goal with consumer members. The results show that CSR perceptions have a direct effect on member loyalty, and psychological ownership and customer citizenship behaviour serially mediate the relationship between perceived CSR and member loyalty. This paper provides empirical support for suggestions about the factors influencing member loyalty within consumer cooperatives and the relative importance of non‐financial motivations. It also provides a foundation upon which practitioners of cooperatives can build more effective CSR communications strategies with members.
Beyond hemoglobin: Critical role of 2,3‐bisphosphoglycerate mutase in kidney function and injury
Authors: Kulow Vera A. , Roegner Kameliya , Labes Robert , Kasim Mumtaz , Mathia Susanne , Czopek Claudia S. , Berndt Nikolaus , Becker Philipp N. , Ter‐Avetisyan Gohar , Luft Friedrich C. , Enghard Philipp , Hinze Christian , Klocke Jan , Eckardt Kai‐Uwe , Schmidt‐Ott Kai M. , Persson Pontus B. , Rosenberger Christian , Fähling Michael 
Published: October 2024

AbstractAim2,3‐bisphosphoglycerate mutase (BPGM) is traditionally recognized for its role in modulating oxygen affinity to hemoglobin in erythrocytes. Recent transcriptomic analyses, however, have indicated a significant upregulation of BPGM in acutely injured murine and human kidneys, suggesting a potential renal function for this enzyme. Here we aim to explore the physiological role of BPGM in the kidney.MethodsA tubular‐specific, doxycycline‐inducible Bpgm‐knockout mouse model was generated. Histological, immunofluorescence, and proteomic analyses were conducted to examine the localization of BPGM expression and the impact of its knockout on kidney structure and function. In vitro studies were performed to investigate the metabolic consequences of Bpgm knockdown under osmotic stress.ResultsBPGM expression was localized to the distal nephron and was absent in proximal tubules. Inducible knockout of Bpgm resulted in rapid kidney injury within 4 days, characterized by proximal tubular damage and tubulointerstitial fibrosis. Proteomic analyses revealed involvement of BPGM in key metabolic pathways, including glycolysis, oxidative stress response, and inflammation. In vitro, Bpgm knockdown led to enhanced glycolysis, decreased reactive oxygen species elimination capacity under osmotic stress, and increased apoptosis. Furthermore, interactions between nephron segments and immune cells in the kidney suggested a mechanism for propagating stress signals from distal to proximal tubules.ConclusionBPGM fulfills critical functions beyond the erythrocyte in maintaining glucose metabolism in the distal nephron. Its absence leads to metabolic imbalances, increased oxidative stress, inflammation, and ultimately kidney injury.
SET facilitates immune escape of microsatellite stability colorectal cancer by inhibiting c‐Myc degradation
Authors: Gao Liping , Li Yizhang , Wang Haizhou , Liu Jialong , Zhang Ranran , Shan Wenqing , Zeng Lingxiu , Zhao Qiu , Li Yong , Liu Jing 
Published: October 2024

AbstractMicrosatellite stability (MSS) colorectal cancer (CRC) exhibits a low mutation load and poor immunogenicity, contributing to immune escape of tumor cells and less benefit from immune checkpoint blockade (ICB) treatment. The mechanisms underlying immunotherapeutic resistance in MSS CRC remain to be elucidated. Here, we identified that nuclear proto‐oncogene SET is significantly higher expressed in MSS CRC compared to microsatellite instability (MSI) CRC and facilitates immune escape of MSS CRC. Mechanistically, SET represses the expression of C‐C motif chemokine ligand 5 (CCL5) and upregulates mismatch repair (MMR) proteins expression in a c‐Myc‐dependent manner, which inhibits infiltration and migration of CD8+ T cells to tumor tissues and results in low immunogenicity in MSS CRC. In addition, we found that SET impairs ubiquitination and proteasomal degradation of c‐Myc by disrupting the interaction between E3 ligase FBXW7 and c‐Myc. Moreover, SET inhibition enhances the response to immunotherapy in MSS CRC in vivo. Overall, this study reveals the critical roles and posttranslational regulatory mechanism of SET in immune escape and highlights the SET/c‐Myc axis as a potential target for immunotherapy of MSS CRC that have implications for targeting a unique aspect of this disease.
Feasibility of a Cardiac Magnetic Resonance Protocol for “off‐on” Cardiac Resynchronization Therapy Evaluation
Authors: Basile Christian , Scatteia Alessandra , Giacopelli Daniele , Gallo Paolo , Pezzullo Salvatore , Mancusi Costantino , Pascale Carmine E. , Gargiulo Paola , Marzano Federica , Perrone‐Filardi Pasquale , Paolillo Stefania , Dellegrottaglie Santo 
Published: October 2024

ABSTRACTBackgroundCardiac resynchronization therapy (CRT) is a standard treatment for patients with heart failure and electrical dyssynchrony. Cardiac magnetic resonance (CMR) is the gold standard for assessing left ventricular (LV) function. However, the feasibility of using CMR with active CRT is still uncertain.PurposeTo assess the feasibility of a CRT “off‐on” protocol during CMR and measure the acute effects of CRT interruption on LV function.MethodsPatients underwent CMR before (pre‐CRT) and 6 months after (post‐CRT) an MR‐conditional CRT defibrillator implantation. The post‐CRT scan included two complete sets of cine images, one with inactive (post‐CRTOFF) and one with active CRT (post‐CRTON), maintaining a continuous connection between device and programmer.ResultsOut of 29 enrolled patients, 8 (28%) had complete and analyzable post‐CRT data. Unsuccessful procedures were attributed to connection problems between the CRT device and the programmer (n = 10), poor image quality (n = 7), and lack of patient cooperation (n = 4). LV ejection fraction significantly increased between pre‐CRT scan (28.1%) and both post‐CRTOFF (37.9%; p = 0.046) and post‐CRTON CMR (35.0%; p = 0.037), with a nonstatistically significant trend toward decreased LV volumes. No adverse events or significant changes in device electrical parameters (including battery level) were detected during the post‐CMR scan period.ConclusionA CRT “off‐on” protocol during CMR studies can be safely executed in patients with an MR‐conditional CRT defibrillator. However, technical improvements are needed to facilitate high‐quality scans during active CRT. Favorable changes in LV function induced by CRT remodeling were not acutely reversed with the interruption of electrical therapy.
Dominance of a highly invasive ant is limited to the nesting territory of its supercolony
Authors: Chifflet Lucila , Calcaterra Luis A. 
Published: October 2024

Abstract
Ant invasions represent a serious threat to biodiversity, agriculture and public health. Highly invasive ant species exhibit a very high abundance within its introduced range and cause severe impacts on native ant communities. This scenario tends to be different within the native range, where competitor ants may limit its access to food sources, thus its abundance.
Here, we evaluated the competitive ability of a typical clonal and supercolonial native population of Wasmannia auropunctata (Roger) (Hymenoptera: Formicidae) in Argentina. We used a combination of pitfall traps and food baits to study the ant interactions within an assemblage where W. auropunctata coexists with another great invader, Solenopsis invicta (Buren) (Hymenoptera: Formicidae).
The studied assemblage presented 56 ant species/morphospecies. Although W. auropunctata was the most abundant numerically, its ability to discover baits was intermediate, and its ability to recruit workers massively and monopolise baits was low. Wasmannia auropunctata was not successful defending baits nor attempting to usurp baits dominated by other species.
Moreover, it lost all contests against S. invicta, one of the most ecologically dominant species in this assemblage. Wasmannia auropunctata dominated food sources only when they were located within the nesting territory of its supercolony.
Within the native range, clonality and supercoloniality may favour the local numerical abundance of a highly invasive ant but may not be enough to achieve ecological dominance. This study sheds light on the important role of biotic interactions as a key factor that may limit the dispersal of invasive species.
Integrating artificial intelligence into team decision‐making: Toward a theory of AI–human team effectiveness
Authors: Carter William , Wynne Kevin T. 
Published: October 2024

AbstractArtificial intelligence (AI), a technological advancement radically affecting the workplace of the future, offers benefits for decision‐making processes. The most critical organizational decisions typically occur through teams. However, team theories are fundamentally psychosocial, and AI disrupts this context by introducing a non‐human actor. Therefore, negative implications of AI's role must also be understood. Toward theory on the effective integration of AI into team decision‐making, we synthesize the literatures on team effectiveness and team decision‐making with research from cognate disciplines on human–technology interaction and teaming. Based on this synthesis, we offer propositions highlighting key variable relationships and negative side effects that must be accounted for in AI–human team decision‐making and follow with practical suggestions for management's adaption to this new context. Overall, our analysis emphasizes critical themes, constructs, and relationships valuable for further research aimed at modernizing theory and practice in the face of this emerging technological shift.
Communicatively constructing resilience: Exploring family resilience in the experience of hereditary cancer
Authors: Campbell‐Salome Gemme , Chernichky‐Karcher Skye , Dean Marleah 
Published: October 2024

AbstractObjectiveThe goal was to explore how families communicate to cope with hereditary cancer conditions and identify factors that may enhance resilience and recommended decision‐making.BackgroundFamilies with Hereditary Breast and Ovarian Cancer syndrome (HBOC), Lynch syndrome (LS), and Li‐Fraumeni syndrome (LFS) have an increased lifetime risk of developing cancer. We use the communication theory of resilience (CTR) to examine how families engage in resilience and make health decisions about hereditary cancer risks over time.MethodWe conducted 42 dyadic interviews with families with HBOC, LS, and LFS. Themes emerged through qualitative analysis for each of the resilience processes outlined by CTR (crafting normalcy, communication networks, identity anchors, alternative logics, and foregrounding productive action while legitimizing negative feelings), illustrating how family members manage stressors associated with hereditary cancer over time.ResultsParticipants described enacting each of the five CTR processes to manage the acute and chronic stressors associated with hereditary cancer. We described themes that emerged within each of the five resilience processes.ConclusionFindings demonstrate the ways in which families managing hereditary cancer risks enact resilience processes and how these processes may have a complex relationship to coping and medical decision‐making.ImplicationsFindings demonstrate areas for intervention to support familial resilience.