bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communicating with participants during the conduct of multi-center clinical trials
Authors: Augustine Erika F , Dorsey E Ray , Hauser Robert A , Elm Jordan J , Tilley Barbara C , Kieburtz Karl K 
Published: August 2016

Background: Communicating with trial participants is an important aspect of study conduct, relevant for informed consent and respect for participants. Group teleconferences are one means to convey information to trial participants. We used group teleconferences during an ongoing large-scale clinical trial to communicate important trial updates. Methods: The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson’s Disease Longitudinal Study-1 trial studied creatine for treatment of early-stage Parkinson’s disease. A total of 1741 participants enrolled at 45 sites in the United States and Canada to take part in a double-blind randomized trial of 5 years of treatment with creatine versus placebo. The study leadership held two teleconferences with study participants and their caregivers after each of two pre-specified interim analyses, for a total of four teleconferences. Each agenda included a presentation by study leadership followed by an open question and answer period. Teleconference recordings were made available to all site personnel and trial participants. Recordings were reviewed and abstracted for themes and topics of the presentations, participant questions, and discussion. Number of participants, connection time for each participant, number of questions, and caller connection time were summarized using descriptive statistics. After the first teleconferences, participants who remained on the call until the end were invited to complete a voluntary, four-question survey about the teleconference process. During the second teleconferences, participants were notified of premature study closure. Results: There were 258 callers for the first pair of teleconferences and 604 callers for the second pair of teleconferences. Study leaders answered more than 110 questions from study participants and caregivers across all calls. The most frequently asked question themes related to study drug, Parkinson’s disease, side effects, future research, and data analysis. The initial teleconferences were well received by participants. Based on responses to the post-call survey, 98% (118/121) of participants found the call useful, 91% (115/127) were interested in future similar calls, 88% stated the call made them more likely to continue in the study (112/128), and 85% (90/106) were satisfied overall with study communications. Conclusion: Teleconferences provide a convenient way to communicate with trial participants and can be used during the conduct of clinical trials to convey study progress and other information. For multi-site trials, teleconferences enable participants to engage directly with study leadership and to ask questions. Survey respondents were highly satisfied with the group teleconference experience. Future research is needed to determine whether teleconferences improve participants’ satisfaction with clinical trial participation and improve retention.
How are allied health notes used for inpatient care and clinical decision-making? A qualitative exploration of the views of doctors, nurses and allied health professionals
Authors: Pain Tilley , Kingston Gail , Askern Janet , Smith Rebecca , Phillips Sandra , Bell Leanne 
Published: August 2016

Background: Inpatient care is dependent upon the effective transfer of clinical information across multiple professions. However, documented patient clinical information generated by different professions is not always successfully transferred between them. One obstacle to successful information transfer may be the reader’s perception of the information, which is framed in a particular professional context, rather than the information per se. Objective: The aim of this research was to investigate how different health professionals perceive allied health documentation and to investigate how clinicians of all experience levels across medicine, nursing and allied health perceive and use allied health notes to inform their decision-making and treatment of patients. Method: The study used a qualitative approach. A total of 53 speech pathologists, nurses, doctors, occupational therapists, dieticians and social workers (8 males; 43 females) from an Australian regional tertiary hospital participated in eleven single discipline focus groups, conducted over 4 months in 2012. Discussions were recorded and transcribed verbatim and coded into themes by content analysis. Findings: Six themes contributing to the efficacy of clinical information transference emerged from the data: day-to-day care, patient function, discharge and discharge planning, impact of busy workloads, format and structure of allied health documentation and a holistic approach to patient care. Discussion: Other professions read and used allied health notes albeit with differences in focus and need. Readers searched for specific pieces of information to answer their own questions and professional needs, in a process akin to purposive sampling. Staff used allied health notes to explore specific aspects of patient function but did not obtain a holistic picture. Conclusion: Improving both the relationship between the various health professions and interpretation of other professions’ documented clinical information may reduce the frequency of communication errors, thereby improving patient care.
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice
Authors: Stark Konstantin , Philippi Vanessa , Stockhausen Sven , Busse Johanna , Antonelli Antonella , Miller Meike , Schubert Irene , Hoseinpour Parandis , Chandraratne Sue , von Brühl Marie-Luise , Gaertner Florian , Lorenz Michael , Agresti Alessandra , Coletti Raffaele , Antoine Daniel J. , Heermann Ralf , Jung Kirsten , Reese Sven , Laitinen Iina , Schwaiger Markus , Walch Axel , Sperandio Markus , Nawroth Peter P. , Reinhardt Christoph , Jäckel Sven , Bianchi Marco E. , Massberg Steffen 
Published: August 2016

Key Points
Sterile inflammation inducing venous thrombosis is coordinated by the damage-associated molecular pattern HMGB1 delivered by platelets. The effect of HMGB1 depends on the redox form, and disulfide HMGB1 induces NET formation, platelet aggregation, and monocyte activation.
CryGetter: a tool to automate retrieval and analysis of Cry protein data
Authors: Buzatto David , de Castro França Suzelei , Zingaretti Sônia Marli 
Published: August 2016

Abstract
Background
For many years, the use of chemical agents to control crop pests has been degrading the environment, bringing problems to humans and all living things. An alternative to deal with the pests is the use of biopesticides, biological agents capable of controlling these harmful organisms. One kind of biopesticide is Bacillus thuringiensis, a Gram-positive bacterium that synthesizes a protein that, when ingested by the pests, kills them and does not harm other species.

Results
Since the economical importance of Bacillus thuringiensis and its proteins significance, this work presents a software tool, called CryGetter, that is capable of retrieving data related to these proteins, store it and present it in a user friendly manner. The tool also aims to align the protein sequences and generate reports containing some statistical data concerning the alignments that were made.

Conclusions
CryGetter was created to help researchers of Bacillus thuringiensis and its proteins to speed up their data retrieval and analysis, allowing them to generate more accurate results. In this sense, the tool circumvents the error prone task of manually getting all the necessary data and processing them in various software systems to get the same result as CryGetter gets in a unique semiautomatic environment.
Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group
Authors: Kovacs Gabor , Robrecht Sandra , Fink Anna Maria , Bahlo Jasmin , Cramer Paula , von Tresckow Julia , Maurer Christian , Langerbeins Petra , Fingerle-Rowson Günter , Ritgen Matthias , Kneba Michael , Döhner Hartmut , Stilgenbauer Stephan , Klapper Wolfram , Wendtner Clemens-Martin , Fischer Kirsten , Hallek Michael , Eichhorst Barbara , Böttcher Sebastian 
Published: August 2016

Purpose To determine the value of minimal residual disease (MRD) assessments, together with the evaluation of clinical response in chronic lymphocytic leukemia according to the 2008 International Workshop on Chronic Lymphocytic Leukemia criteria. Patients and Methods Progression-free survival (PFS) and overall survival of 554 patients from two randomized trials of the German CLL Study Group (CLL8: fludarabine and cyclophosphamide [FC] v FC plus rituximab; CLL10: FC plus rituximab v bendamustine plus rituximab) were analyzed according to MRD assessed in peripheral blood at a threshold of 10−4 and clinical response. The prognostic value of different parameters defining a partial response (PR) was further investigated. Results Patients with MRD-negative complete remission (CR), MRD-negative PR, MRD-positive CR, and MRD-positive PR experienced a median PFS from a landmark at end of treatment of 61 months, 54 months, 35 months, and 21 months, respectively. PFS did not differ significantly between MRD-negative CR and MRD-negative PR; however, PFS was longer for MRD-negative PR than for MRD-positive CR ( P = .048) and for MRD-positive CR compared with MRD-positive PR ( P = .002). Compared with MRD-negative CR, only patients with MRD-positive PR had a significantly shorter overall survival (not reached v 72 months; P = .001), whereas there was no detectable difference for patients with MRD-negative PR or MRD-positive CR ( P = 0.612 and P = 0.853, respectively). Patients with MRD-negative PR who presented with residual splenomegaly had only a similar PFS (63 months) compared with patients with MRD-negative CR (61 months; P = .354), whereas patients with MRD-negative PR with lymphadenopathy showed a shorter PFS (31 months; P < .001). Conclusion MRD quantification allows for improved PFS prediction in both patients who achive PR and CR, which thus supports its application in all responders. In contrast to residual lymphadenopathy, persisting splenomegaly does not impact outcome in patients with MRD-negative PR.
Salvage Radiotherapy for Biochemically Recurrent Prostate Cancer After Prostatectomy
Authors: Zumsteg Zachary S. , Daskivich Timothy J. , Sandler Howard M. 
Published: August 2016

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 67-year-old man had presented to his primary physician for routine health maintenance. A digital rectal examination was performed and revealed a suspicious nodule in the right lobe of the prostate without any extraprostatic extension. A serum prostate-specific antigen (PSA) test was 12.4 ng/mL. He had no previous PSA tests. Transrectal ultrasound-guided prostate biopsy showed Gleason 3 + 4 prostate adenocarcinoma in seven of 12 cores. Bone scan and computed tomography scan of the pelvis showed no evidence of metastatic disease, and the patient underwent a robotic-assisted radical prostatectomy with bilateral pelvic lymphadenectomy. Pathology revealed Gleason 3 + 4 adenocarcinoma bilaterally, with extracapsular extension, no seminal vesicle invasion, a 2-mm positive margin at the right mid gland, and 0 of 15 lymph nodes containing adenocarcinoma. Two months after surgery, he had mild stress urinary incontinence and PSA of < 0.1 ng/mL. Adjuvant radiotherapy was discussed, but he elected to have careful follow-up. His PSA was monitored every 6 months and gradually increased from < 0.1 ng/mL to 0.4 ng/mL over the next 3 years. He was asymptomatic. He was referred to discuss the role of salvage radiotherapy.
Postprandial Monocyte Activation in Individuals With Metabolic Syndrome
Authors: Khan Ilvira M. , Pokharel Yashashwi , Dadu Razvan T. , Lewis Dorothy E. , Hoogeveen Ron C. , Wu Huaizhu , Ballantyne Christie M. 
Published: August 2016

Context:
Postprandial hyperlipidemia has been suggested to contribute to atherogenesis by inducing proinflammatory changes in monocytes. Individuals with metabolic syndrome (MS), shown to have higher blood triglyceride concentration and delayed triglyceride clearance, may thus have increased risk for development of atherosclerosis.

Objective:
Our objective was to examine fasting levels and effects of a high-fat meal on phenotypes of monocyte subsets in individuals with obesity and MS and in healthy controls.

Design, Setting, Participants, Intervention:
Individuals with obesity and MS and gender- and age-matched healthy controls were recruited. Blood was collected from participants after an overnight fast (baseline) and at 3 and 5 hours after ingestion of a high-fat meal. At each time point, monocyte phenotypes were examined by multiparameter flow cytometry.

Main Outcome Measures:
Baseline levels of activation markers and postprandial inflammatory response in each of the three monocyte subsets were measured.

Results:
At baseline, individuals with obesity and MS had higher proportions of circulating lipid-laden foamy monocytes than controls, which were positively correlated with fasting triglyceride levels. Additionally, the MS group had increased counts of nonclassical monocytes, higher CD11c, CX3CR1, and human leukocyte antigen-DR levels on intermediate monocytes, and higher CCR5 and tumor necrosis factor-α levels on classical monocytes in the circulation. Postprandial triglyceride increases in both groups were paralleled by upregulation of lipid-laden foamy monocytes. MS, but not control, subjects had significant postprandial increases of CD11c and percentages of IL-1β+ and tumor necrosis factor-α+ cells in nonclassical monocytes.

Conclusions:
Compared to controls, individuals with obesity and MS had increased fasting and postprandial monocyte lipid accumulation and activation.
Phylogeny of non‐monophyletic Teucrium (Lamiaceae: Ajugoideae): Implications for character evolution and taxonomy
Authors: Salmaki Yasaman , Kattari Stefan , Heubl Günther , Bräuchler Christian 
Published: August 2016

AbstractTeucrium, with an almost cosmopolitan distribution, comprises about 250 species and is the second ‐ largest genus of subfamily Ajugoideae (Lamiaceae). Phylogenetic studies were conducted using nuclear ribosomal DNA (ITS) and chloroplast (ndhF gene, trnL‐F region) DNA sequence data from 101 taxa to estimate phylogenetic relationships among Teucrium and its closest allies. We conclude that: (1) Teucridium, Spartothamnella and Oncinocalyx are nested within Teucrium, thus rendering the latter paraphyletic; (2) previously proposed taxonomic classification systems for Teucrium mostly are not supported by our phylogenetic results; (3) Rubiteucris and Schnabelia appear to be sister to Teucrium. Our results indicate that, among various morphological characters, the calyx shape is diagnostic for different clades within Teucrium. Based on the cladograms derived in this study, the pattern of karyotype evolution suggests that switches in ploidy level are common in at least two groups. Adaptations to drought stress and the regional establishment of Mediterranean climates obviously facilitated speciation and the spread of the genus. Molecular dating analyses indicate diversification of Teucrium at the middle/late Miocene boundary, correlated with Tertiary climatic and tectonic changes.
On a Role of Hearing Protection Equipment under Conditions of In-Plant Noise Harmful Impact
Authors: Панкова  , Pankova V. , Капцов  , Kaptsov V. , Чиркин  , Chirkin A. 
Published: August 2016

Статья является ответом на ранее опубликованную статью в журнале «Безопасность в техносфере» (2015. № 2. с. 40-47, авторы Готлиб Я.Г., Алимов Н.П.),
в которой предлагалось снизить класс условий труда при обеспечении рабочих средствами индивидуальной защиты органов слуха, повысить предельно-допустимый уровень шума для рабочих мест. Кратко описаны современные
представления о воздействии шума на здоровье человек, об эффективности
средств индивидуальной защиты при их реальном применении. Показано, что
предложения авторов указанной статьи обоснованы некорректно, не соответствуют современному уровню мировой науки, и их выполнение может ухудшить
здоровье работников. Показано возможное негативное последствие снижения
классов условий труда при обеспечении рабочих средствами защиты, даны рекомендации по снижению вызванной шумом профессиональной заболеваемости.
Men, masculinity and style in 2008: A study of men’s clothing considerations in the latter aughts
Authors: Green Denise Nicole , Kaiser Susan B. 
Published: August 2016

Abstract
This article examines how, in the latter aughts, men from the United States thought about their style, favourite clothing, masculine style(s) and the ways they imagined masculinity as articulated through everyday practices of fashioning the body. The body is a site of identity production, situated within broader cultural expectations, commitments and ideals. This study explores men’s relationships to masculine ideals while dressing the body. We ask: how do men think about masculinity in relation to dress? How do they define ‘masculine style’? In this article we examine individual responses about everyday appearance decisions, as well as larger trends. The study is a cross-section from a particular moment in time (May 2008) and uses demographically balanced open-ended survey responses to gauge men’s relationships to masculine ideals while dressing the body. We use descriptive statistics to illustrate how men in the United States – at a particularly transitional moment in time – articulated their perspectives on favourite clothes and masculine style.
Head circumference and anterior fontanel measurements in newborns
Authors: Tiansyah Rizal Agus , Mangunatmadja Irawan , Pulungan Aman 
Published: August 2016

Background Head growth and anterior fontanel (AP) closureare passive processes in response to brain growth. The growthof the brain and skull starts in the third week of intrauterinegestation. roth processes run simultaneously as a part of integralgrowth, along 'With increasing gestational age, until post􀀿birth.Measurement of head circumference (He) and AF in newbornsis done to determine if the brain and skull grew normally duringthe intrauterine period.Objectives To investigate the differences in He and AF sizebetween preterm and full􀀿term infants, and the relationshipbetween gestational age (GA) and birth weight (BW) to Heand AF size.Methods This was a descriptive analytic study on preterm andfull􀀿term newborns. Measurement of HC and AF was conductedin three phases: just after birth, 1x24 and 2x24 hours of age.Analysis of HC and AF size differences between preterm and fullterm subjects was performed, as well as analysis of the correlationbetween GA and BW to HC and AF size.Results Two hundred fifty newborns completed the study. Therewere 180 full􀀿term and 70 preterm subjects. Median HC in full􀀿term and preterm male subjects were 34 cm (range 31􀀿37 cm)and 31 cm (27􀀿34 cm), respectively. Median HC in full􀀿termand preterm female subjects were 33 cm (31􀀿36 cm) and 32 cm(27􀀿3S.S cm), respectively. Median AF in full􀀿term and pretermmale subjects were 2.17 cm (1.0SA.6 cm) and 2.22 cm (1.3SA.Scm), respectively, and in full􀀿term and preterm female subjectswere 2.02 cm (lA.1S cm) and 2.22 cm (0.7SA cm), respectively.The HC of preterms were significantly lower than the fullterms(P<O.OOl), however the AF size was not different between these2 groups of newborns (P =0 .28). Correlation test between GA andBW to HC size revealed a positive correlation (r=0.620, P<O.OO 1and r=0.801, P<O.OOl, respectively), but not to AF size (r=􀀿 0.06,p􀁀 0.279 and F- 0.049, P􀁀0.44, respectively).Concl usions We found that the HC size of pre terms wassignificantly lower than thefullterms, but no significant differences in AF size between the two groups. GA and BW were associatedwith HC size, but not associated to AF size. [paediatr lndones.2012;52:145-51].
Solubility and hydrolysis of Np(V) in dilute to concentrated alkaline NaCl solutions: formation of Na–Np(V)–OH solid phases at 22 °C
Authors: Petrov Vladimir G. , Fellhauer David , Gaona Xavier , Dardenne Kathy , Rothe Jörg , Kalmykov Stepan N. , Altmaier Marcus 
Published: August 2016

Abstract
The solubility of Np(V) was investigated at T=22±2°C in alkaline NaCl solutions of different ionic strength (0.1–5.0 M). The solid phases controlling the solubility at different –log10 mH+(pHm) and NaCl concentration were characterized by XRD, quantitative chemical analysis, SEM–EDS and XAFS (both XANES and EXAFS). Aqueous phases in equilibrium with Np(V) solids were investigated for selected samples within 8.9≤pHm≤10.3 by UV-vis/NIR absorption spectroscopy. In 0.1 M NaCl, the experimental solubility of the initial greenish NpO2OH(am) solid phase is in good agreement with previous results obtained in NaClO4 solutions, and is consistent with model calculations for fresh NpO2OH(am) using the thermodynamic data selection in NEA–TDB. Below pHm~11.5 and for all NaCl concentrations studied, Np concentration in equilibrium with the solid phase remained constant during the timeframe of this study (~2 years). This observation is in contrast to the aging of the initial NpO2OH(am) into a more crystalline modification with the same stoichiometry, NpO2OH(am, aged), as reported in previous studies for concentrated NaClO4 and NaCl. Instead, the greenish NpO2OH(am) transforms into a white solid phase in those systems with [NaCl]≥1.0 M and pHm≥11.5, and into two different pinkish phases above pHm~13.2. The solid phase transformation is accompanied by a drop in Np solubility of 0.5–2 log10-units (depending upon NaCl concentration). XANES analyses of green, white and pink phases confirm the predominance of Np(V) in all cases. Quantitative chemical analysis shows the incorporation of Na+ in the original NpO2OH(am) material, with Na:Np≤0.3 for the greenish solids and 0.8≤Na:Np≤1.6 for the white and pinkish phases. XRD data confirms the amorphous character of the greenish phase, whereas white and pink solids show well-defined but discrepant XRD patterns. Furthermore, the XRD pattern collected for one of the pink solid phases match the data recently reported for NaNpO2(OH)2(cr). UV-vis/NIR spectra collected in 0.1–5.0 M NaCl solutions show the predominance of NpO2
+ (≥80%) at pHm≤10.3. This observation is consistent with the Np(V) hydrolysis scheme currently selected in the NEA–TDB. This work provides sound evidences on the formation of ternary Na–Np(V)–OH solid phases in Na-rich hyperalkaline solutions and ambient temperature conditions. Given the unexpectedly high complexity of the system, further experimental efforts dedicated to assess the thermodynamic properties of these solid phases are needed, especially in view of their likely relevance as solubility controlling Np(V) solid phases in Na-rich systems such as saline and cement-based environments in the context of the safety assessment for nuclear waste disposal.