bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed facial nerve decompression for severe refractory cases of Bell's palsy: A 25-year experience
Authors: Berania Ilyes , Awad Mohamed , Saliba Issam , Dufour Jean-Jacques , Nader Marc-Elie 
Published: January 2018

Background This study aims to assess the effectiveness of delayed facial nerve decompression for Bell's palsy (BP). Methods We performed a retrospective case review of all patients having undergone facial nerve decompression for severe refractory BP between 1984 and 2009 at our tertiary referral center. Demographics, timing between onset of symptoms and surgical decompression, degree of facial nerve dysfunction pre- and post-operatively, follow-up length after surgery and postoperative complications were recorded. Facial nerve dysfunction was assessed using the House-Brackmann (HB) scale. Electroneuronography, electromyography and imaging results were assessed when available. Results Eighteen patients had surgery between 21 and 60 days after onset of BP (group I), and 18 patients had surgery more than 60 days after onset of symptoms (group II). In group II, 11 patients had surgery between 61 and 89 days and 7 patients after 90 days. Groups I and II showed similar functional gain and rates of improvement to HB 3 or better (11/18 vs. 11/18, p > 0.05). In group II, patients operated 60 to 89 days after onset of BP showed a significantly higher rate of improvement to HB 3 or better (9/11 vs. 2/6, p = 0.049) with higher functional gain compared to those operated after 90 days ( p = 0.0293). Conclusions When indicated, facial nerve decompression for BP is usually recommended within the first 2 weeks of onset of facial paralysis. Nonetheless, our results suggest that patients with severe BP could benefit from decompression surgery within 90 days after onset of symptoms in the absence of an opportunity to proceed earlier to surgery. Further investigation is still required to confirm our findings. Trial registration Retrospective registered. IRB# 2016–6154, CE 15.154 – CA
Nodal induces sequential restriction of germ cell factors during primordial germ cell specification
Authors: Fresques Tara M. , Wessel Gary M. 
Published: January 2018

ABSTRACT
Specification of the germ cell lineage is required for sexual reproduction in animals. The mechanism of germ cell specification varies among animals but roughly clusters into either inherited or inductive mechanisms. The inductive mechanism, the use of cell-cell interactions for germ cell specification, appears to be the ancestral mechanism in animal phylogeny, yet the pathways responsible for this process are only recently surfacing. Here, we show that germ cell factors in the sea star initially are present broadly, then become restricted dorsally and then in the left side of the embryo where the germ cells form a posterior enterocoel. We find that Nodal signaling is required for the restriction of two germ cell factors, Nanos and Vasa, during the early development of this animal. We learned that Nodal inhibits germ cell factor accumulation in three ways including: inhibition of specific transcription, degradation of specific mRNAs and inhibition of tissue morphogenesis. These results document a signaling mechanism required for the sequential restriction of germ cell factors, which causes a specific set of embryonic cells to become the primordial germ cells.
No Effect of Muscle Stretching within a Full, Dynamic Warm-up on Athletic Performance
Authors: BLAZEVICH ANTHONY J. , GILL NICHOLAS D. , KVORNING THUE , KAY ANTHONY D. , GOH ALVIN G. , HILTON BRADLEY , DRINKWATER ERIC J. , BEHM DAVID G. 
Published: January 2018

ABSTRACT

Purpose
This study aimed to examine the effects of static and dynamic stretching routines performed as part of a comprehensive warm-up on flexibility and sprint running, jumping, and change of direction tests in team sport athletes.

Methods
A randomized, controlled, crossover study design with experimenter blinding was conducted. On separate days, 20 male team sport athletes completed a comprehensive warm-up routine. After a low-intensity warm-up, a 5-s static stretch (5S), a 30-s static stretch (30S; 3 × 10-s stretches), a 5-repetition (per muscle group) dynamic stretch (DYN), or a no-stretch (NS) protocol was completed; stretches were done on seven lower body and two upper body regions. This was followed by test-specific practice progressing to maximum intensity. A comprehensive test battery assessing intervention effect expectations as well as flexibility, vertical jump, sprint running, and change of direction outcomes was then completed in a random order.

Results
There were no effects of stretch condition on test performances. Before the study, 18/20 participants nominated DYN as the most likely to improve performance and 15/20 nominated NS as least likely. Immediately before testing, NS was rated less “effective” (4.0 ± 2.2 on a 10-point scale) than 5S, 30S, and DYN (5.3–6.4). Nonetheless, these ratings were not related to test performances.

Conclusion
Participants felt they were more likely to perform well when stretching was performed as part of the warm-up, irrespective of stretch type. However, no effect of muscle stretching was observed on flexibility and physical function compared with no stretching. On the basis of the current evidence, the inclusion of short durations of either static or dynamic stretching is unlikely to affect sprint running, jumping, or change of direction performance when performed as part of a comprehensive physical preparation routine.
Nursing care for people dying from chronic obstructive airways disease
Authors: Skilbeck Julie , Mott Laurie , Smith Diane , Page Hilary , Clark David 
Published: January 2018

Nursing has demonstrated its ability to respond to the palliative care needs of patients, and their families, with advanced cancer. One of the current challenges to palliative care nursing lies in meeting the needs of patients with a diagnosis other than cancer. This paper reports on how nursing is currently organised and delivered to those individuals dying from chronic obstructive airways disease (COAD). The study findings illustrate a group of people whose quality of life is perceived to be poor, and whose health burden is considerable. Currently, nursing knowledge, skills and expertise are being under-utilised within the care of this patient group, and this requires urgent attention by purchasers and providers.
Issues affecting the delivery of palliative care in Russia
Authors: Jones Wendy 
Published: January 2018

Today's Russia is a complex society with a complex history and a rich variety of ethnic groups represented among its peoples. This paper describes some of the important factors which provide challenges for the delivery of palliative care against the backcloth of conditions in modern Russia. After a short account of some of the relevant health statistics, and how the demography of the country is affected by them, the issues which impinge more directly on the delivery of palliative care are discussed.
In Situ Detection and Quantification of AR-V7, AR-FL, PSA, and KRAS Point Mutations in Circulating Tumor Cells
Authors: El-Heliebi Amin , Hille Claudia , Laxman Navya , Svedlund Jessica , Haudum Christoph , Ercan Erkan , Kroneis Thomas , Chen Shukun , Smolle Maria , Rossmann Christopher , Krzywkowski Tomasz , Ahlford Annika , Darai Evangelia , von Amsberg Gunhild , Alsdorf Winfried , König Frank , Löhr Matthias , de Kruijff Inge , Riethdorf Sabine , Gorges Tobias M , Pantel Klaus , Bauernhofer Thomas , Nilsson Mats , Sedlmayr Peter 
Published: January 2018

Abstract

BACKGROUND
Liquid biopsies can be used in castration-resistant prostate cancer (CRPC) to detect androgen receptor splice variant 7 (AR-V7), a splicing product of the androgen receptor. Patients with AR-V7-positive circulating tumor cells (CTCs) have greater benefit of taxane chemotherapy compared with novel hormonal therapies, indicating a treatment-selection biomarker. Likewise, in those with pancreatic cancer (PaCa), KRAS mutations act as prognostic biomarkers. Thus, there is an urgent need for technology investigating the expression and mutation status of CTCs. Here, we report an approach that adds AR-V7 or KRAS status to CTC enumeration, compatible with multiple CTC-isolation platforms.

METHODS
We studied 3 independent CTC-isolation devices (CellCollector, Parsortix, CellSearch) for the evaluation of AR-V7 or KRAS status of CTCs with in situ padlock probe technology. Padlock probes allow highly specific detection and visualization of transcripts on a cellular level. We applied padlock probes for detecting AR-V7, androgen receptor full length (AR-FL), and prostate-specific antigen (PSA) in CRPC and KRAS wild-type (wt) and mutant (mut) transcripts in PaCa in CTCs from 46 patients.

RESULTS
In situ analysis showed that 71% (22 of 31) of CRPC patients had detectable AR-V7 expression ranging from low to high expression [1–76 rolling circle products (RCPs)/CTC]. In PaCa patients, 40% (6 of 15) had KRAS mut expressing CTCs with 1 to 8 RCPs/CTC. In situ padlock probe analysis revealed CTCs with no detectable cytokeratin expression but positivity for AR-V7 or KRAS mut transcripts.

CONCLUSIONS
Padlock probe technology enables quantification of AR-V7, AR-FL, PSA, and KRAS mut/wt transcripts in CTCs. The technology is easily applicable in routine laboratories and compatible with multiple CTC-isolation devices.
Inside media: Shifts in spectatorship through the ICA’s videotheque and cinematheque
Authors: Bayley Lucy 
Published: January 2018

Abstract
This article explores shifts in spectatorship when London’s Institute of Contemporary Arts (ICA) transformed their existing cinema into a cinematheque (April 1981) and videotheque (January 1982). This space introduced a new model of interactive viewing and memory on demand that built on cybernetic systems and television broadcasting, whilst bringing together the cinema and the gallery. As described at the time ‘[i]n the midst of growing despair and austerity’ of the Thatcherite era, the ‘slick product’ of 1980s videos offered a way for counterculture to move into the mainstream of contemporary arts. Despite this, its history has been largely ignored by both exhibition studies and moving images histories. This article hopes to address this gap by considering dynamic spectatorship, programming and medial transferral through archival material at the ICA and Central Saint Martins, University of the Arts London.
Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children
Authors: Munawwarah Laily , Evalina Rita , Sofyani Sri 
Published: January 2018

Background Vitamin D plays an important role in the immune system. It inhibits B-lymphocyte proliferation and modulates the humoral response to suppress IgE production. Studies on the relationship between serum 25-hydroxyvitamin-D level and the severity of atopic dermatitis in several countries have had varying results.Objective To assess for a possible correlation between serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children.Methods A cross-sectional study was conducted in 26 children with atopic dermatitis from September to December 2015. We evaluated the severity of disease using the Scoring of Atopic Dermatitis (SCORAD) index and measured serum 25-hydroxyvitamin-D levels. Spearman’s test was used to analyze for a correlation between serum 25-hydroxyvitamin-D level and the atopic dermatitis score in children with atopic dermatitis.Results Mean SCORAD index was 32.0 (SD 14.99) , with a range of 10.9 to 71.4. Mean serum 25-hydroxyvitamin-D level was 41.1 (SD 24.81) ng/mL, with a range of 10-137 ng/mL. There was a moderate correlation between serum 25-hydroxyvitamin-D level and the SCORAD index (r=-0.591), with higher SCORAD index associated with lower serum 25-hydroxyvitamin-D level (P=0.01).Conclusion There is a moderate correlation between serum 25-hydroxyvitamin-D level and the SCORAD index in children with atopic dermatitis.
DAKWAH NATIO-EDUCATION PADA MASYARAKAT EKS TAHANAN POLITIK DI KAMPUNG NANGA-NANGA KOTA KENDARI SULAWESI TENGGARA
Authors: Syahrul Syahrul 
Published: January 2018

Kemajemukan bangsa Indonesia tidak hanya pada aspek-aspek yang selama ini populer di masyarakat seperti budaya, suku, bahasa, agama ataupun ras. Lebih dari itu, kemajemuk-an nampak pula pada kondisi sosial yang mengalami pelapisan“atas-menengah-bawah”, terdidik-kurang terdidik, bahkan pelabelan berdasarkan latar belakang afiliasi politik seperti “kiri-tengah-kanan”. Fakta-fakta sosial tersebut menyebabkan terjadinya perbedaan perlakuan bagi masing-masing komunitas yang mengalami polarisasi tersebut baik secara struktural, kultural maupun politik.Mengambil setting pada masyarakat eks tahanan politik di Kampung Nanga-Nanga Kota Kendari Propinsi Sulawesi Tenggara, tulisan ini merupakan upaya melukiskan kondisi suatu komunitas yang mengalami ketidakadilan secara sosial akibat pilihan mereka di masa lalu. Fakta lain yang menjadi sorotan adalah rendahnya partisipasi mereka terhadap pendidikan. Sehingga tulisan ini juga merupakan ikhtiar memberikan tawaran solutif atas permasalahan tersebut.Masyarakat eks tahanan politik Kampung Nanga-Nanga Kota Kendari Propinsi Sulawesi Tenggara adalah komunitas yang diasingkan dari hiruk-pikuk penyelenggaraan negara akibat peristiwa 30 September 1965. Meskipun reformasi pada mei 1998 memberi harapan rehabilitasi, tetapi kondisi traumatik yang demikian kuat tidak memberi perubahan berarti dalam kehidupan sosial masyarakat kampung Nanga-Nanga. Proses isolasi masyarakat eks tahanan politik yang telah berlangsung cukup lama di tempat itu menciptakan stigma bahwa kampung Nanga-Nanga dan masyarakatnya merupakan lapisan asing dalam struktur masyarakat di Kota Kendari.Akibat dari pengasingan itu masyarakat kampung Nanga-Nanga menunjukkan beberapa perilaku seperti: pesimisme dalam berbangsa dan bernegara, apriori terhadap lembaga pendidikan, sensitif terhadap agama, dan tertutup dalam pergaulan sosial.Kondisi masyarakat eks tahanan politik di kampung Nanga-Nanga yang mayoritas beragama Islam menghadirkan tawaran tentang perlunya pendekatan agama dalam konteks membangun kesadaran berbangsa dan menumbuhkan semangat untuk bersekolah. Pendekatan strategis tersebut diharapkan menjadi gerakan dakwah kebangsaan dan perbaikan layanan pendidikan. Akibatnya strategi dakwah ini menuntut keterlibatan seluruh elemen masyarakat baik pemerintah, tokoh agama, tokoh masyarakat, pemuda, mahasiswa dan lembaga pendidikan.
Production of isomelezitose from sucrose by engineered glucansucrases
Authors: Côté Gregory L. , Dunlap Christopher A. , Vermillion Karl E. , Skory Christopher D. 
Published: January 2018

AbstractCertain lactic acid bacteria produce glycosyltransferases known as glucansucrases, which synthesize α-D-glucans via glucosyl transfer from sucrose. We recently reported on the formation of the unusual trisaccharide isomelezitose in low yields by a variety of glucansucrases. Isomelezitose is a rare non-reducing trisaccharide, with the structure α-d-glucopyranosyl- (1→6)-β-d-fructofuranosyl-(2↔1)-α-d-glucopyranoside. In this work, we describe the synthesis of isomelezitose in high yields by variants of glucansucrases engineered to contain a single point mutation at a key leucine residue involved in acceptor substrate binding. Some variants produce isomelezitose in yields up to 57%. This method is amenable to large-scale production of isomelezitose for food, industrial and biomedical applications.
Meet the family − the catalog of known hot subdwarf stars
Authors: Geier Stephan , Østensen Roy H. , Nemeth Peter , Heber Ulrich , Gentile Fusillo Nicola P. , Gänsicke Boris T. , Telting John H. , Green Elizabeth M. , Schaffenroth Johannes 
Published: January 2018

Abstract
In preparation for the upcoming all-sky data releases of the Gaia mission, we compiled a catalog of known hot subdwarf stars and candidates drawn from the literature and yet unpublished databases. The catalog contains 5613 unique sources and provides multi-band photometry from the ultraviolet to the far infrared, ground based proper motions, classifications based on spectroscopy and colors, published atmospheric parameters, radial velocities and light curve variability information. Using several different techniques, we removed outliers and misclassified objects. By matching this catalog with astrometric and photometric data from the Gaia mission, we will develop selection criteria to construct a homogeneous, magnitude-limited all-sky catalog of hot subdwarf stars based on Gaia data. As first application of the catalog data, we present the quantitative spectral analysis of 280 sdB and sdOB stars from the Sloan Digital Sky Survey Data Release 7. Combining our derived parameters with state-of-the-art proper motions, we performed a full kinematic analysis of our sample. This allowed us to separate the first significantly large sample of 78 sdBs and sdOBs belonging to the Galactic halo. Comparing the properties of hot subdwarfs from the disk and the halo with hot subdwarf samples from the globular clusters ! Cen and NGC 2808, we found the fraction of intermediate He-sdOBs in the field halo population to be significantly smaller than in the globular clusters.
Influence of dissolution products of a novel Ca-enriched silicate bioactive glass-ceramic on VEGF release from bone marrow stromal cells
Authors: Balasubramanian Preethi , Detsch Rainer , Esteban-Tejeda Leticia , Grünewald Alina , Moya José S. , Boccaccini Aldo R. 
Published: January 2018

AbstractThis study evaluated the influence of ionic dissolution products of a novel Ca-enriched silicate bioactive glass compared to commercial available hydroxyapaptite samples (Endobonr) on cell activity and vascular endothelial growth factor (VEGF) release in vitro. Bone marrow stromal cells (ST-2) were cultivated with the supernatant of granules of different sizes and at different concentrations (0-1 wt/vol % of granules) for 48 h. In addition to in vitro studies, Ca-ion release from all as cell morphology observation revealed no cytotoxic effect of the released products from all tested materials. It was found that supernatants from granules in concentrations of 1 wt/vol %enhanced the VEGF release from ST2 cells, which is important as a marker of the vascularisation ability of the glass during the bone healing process.
The Politics of Genre and Gender in Tabitha Gilman Tenney’s Female Quixotism
Authors: Ivana Dragoş 
Published: January 2018

Abstract
The present article focuses on transatlantic female quixotism, as enacted by Tabitha Tenney’s heroine, Dorcasina Sheldon. I argue that quixotism can be read as an interface between the events of the story and the Federalist conservative discourse that underlies them. In doing so, I claim that, in terms of gender, the heroine’s misreading of romances transforms her into a political tool whereby the ideals of female freedom and agency, social mobility, gender equality, racial equity and abolitionism-effective under Thomas Jefferson’s administration-are satirically depicted and seen as delusory in post-Revolutionary America. In terms of generic categories, I will show how Female Quixotism blurs the epistemological boundaries between truth and fiction by juxtaposing novel and romance, used interchangeably, with history.
Reduction of free fatty acids in waste oil for biodiesel production by glycerolysis: investigation and optimization of process parameters
Authors: Mićić Radoslav , Tomić Milan , Martinović Ferenc , Kiss Ferenc , Simikić Mirko , Aleksic Aleksandra 
Published: January 2018

Abstract
Influence of the process parameters for the industrially relevant reaction of free fatty acid (FFA) with glycerol is investigated. Furthermore, several drying techniques are investigated and a novel method is suggested that can provide more realistic experimental conditions. Silica as an absorbent is found to be a more suitable method for water removal than distillation or carrier gas. Using response surface methodology, important parameters are identified and optimal conditions found. Empirical correlation is developed to account for the most important parameters. Both oil:glycerol ratio and temperature have optimal values for which the highest conversion can be achieved. Interestingly, the highest conversion can be obtained at 220°C; above this temperature the conversion decreases. It is found that the influence of oil:glycerol ratio also exhibits anomalous behavior, where conversion is constant and decreases above a certain value. At optimal conditions, the FFA is reduced to 1.6% from the initial 8.6%.
Effect of Sclerotinia sclerotiorum on Sunflower Seeds Quality
Authors: Drumeva Miglena , Yankov Petar 
Published: January 2018

AbstractThe investigation was carried out at Dobrudzha Agricultural Institute – General Toshevo, Bulgaria, and encompassed the period 2009–2010. The experiment involved four double haploid fertility restorer lines (DH-R-2, DH-R-7, DH-R-116 and DH-R-128), which have shown in our previous studies various degree of resistance to Sclerotinia sclerotiorum de Bary under artificial infection conditions. Ten plants from each investigated line were inoculated by the Straw-method at stage 5-6th pair of leaves. The plants were self-pollinated and the seeds obtained from them, as well as the seeds from the check plants (not infected), were analyzed for the traits 1000 seed weight, % of kernel, oil in kernel and protein content in kernel. Variations in the quality characteristics of the sunflower seeds were found in all investigated lines, the degree of quality “deterioration” having different expression according to the tolerance of the line to the pathogen. Lines DH-R-2 and DH-R-7 formed seeds with lower seed weight and percent of kernel. These seeds had lower oil and protein content. The established variations in the quality of the seeds between lines DH-R-116 and DH-R-128 and the check variants were not statistically significant.
Mathematical Morphology on Irregularly Sampled Data in One Dimension
Authors: Asplund Teo , Hendriks Cris L. Luengo , Thurley Matthew J. , Strand Robin 
Published: January 2018

AbstractMathematical morphology (MM) on grayscale images is commonly performed in the discrete domain on regularly sampled data. However, if the intention is to characterize or quantify continuous-domain objects, then the discrete-domain morphology is affected by discretization errors that may be alleviated by considering the underlying continuous signal. Given a band-limited image, for example, a real image projected through a lens system, which has been correctly sampled, the continuous signal may be reconstructed. Using information from the continuous signal when applying morphology to the discrete samples can then aid in approximating the continuous morphology. Additionally, there are a number of applications where MM would be useful and the data is irregularly sampled. A common way to deal with this is to resample the data onto a regular grid. Often this creates problems where data is interpolated in areas with too few samples. In this paper, an alternative way of thinking about the morphological operators is presented. This leads to a new type of discrete operators that work on irregularly sampled data. These operators are shown to be morphological operators that are consistent with the regular, morphological operators under the same conditions, and yield accurate results under certain conditions where traditional morphology performs poorly.
Crystal Structure of ethyl (E)-3,4-dimethyl-5-((2-(4-methylbenzoyl)hydrazono)methyl)-1H-pyrrole-2-carboxylate — water — ethanol (1/1/1), C20H29N3O5
Authors: Wu Hao , Hu Qiang , Wang Yuan 
Published: January 2018

Abstract
C20H29N3O5, triclinic, P1̅ (no. 2), a = 9.1571(18) Å, b = 10.505(2) Å, c = 11.576(2) Å, α = 94.509(4)°, β = 92.570(4)°, γ = 102.312(3)°, V = 1082.4(4)) Å3, Z = 2, R
gt(F) = 0.0543, wR
ref(F
2) = 0.1704, T = 296(2) K.