bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal outcomes in new-borns of pregnant women with COVID-19: a case-control study
Authors: Dutra Letícia Veríssimo , Gonçalves Giovana , Silva Mariliza Henrique , Lebrão Cibele , Affonso‑Fonseca Fernando , Suano‑Souza Fabiola 
Published: September 2024

Abstract

Background
The incidence of COVID-19 vertical transmission is approximately 20%, and a shorter interval and greater maternal infection severity increase the risk of mother-to-child transmission.
Objective
This study aims to describe the frequency of COVID-19 positivity and clinical symptoms in newborns of pregnant women who have had COVID-19.
Methods
A case‒control study was carried out with unvaccinated women who had COVID-19 during pregnancy and their newborns. The 23 newborns that tested positive for COVID-19 (RT‒PCR for SARS-CoV-2) in the first 48 hours of life were matched (2:1) by day of birth and sex, with 46 other newborns that tested negative for COVID-19. The following data were collected: time and severity of maternal infection, gestational age, anthropometry, and clinical symptoms of the newborns.
Results
The mean age of the pregnant women was 28.50 ± 6.39 years, and the median time between COVID-19 infection and delivery was 86.0 days (26.5,179). The mean gestational age and birth weight of the newborns were 38.2 ± 1.7 weeks and 2994.2 ± 464.5 grams, respectively. Fifteen (21.7%) of the newborns experienced clinical complications during hospitalization, and the most common complications were early respiratory distress (10.1%), hypotonia/hypoactivity (13.0%), hypoglycemia (1.4%), and vomiting (1.4%). Newborns with positive RT‒PCR results for SARS-CoV-2 had a greater risk of respiratory symptoms (OR = 21.31; 95% CI 2.24 to 201.68; p = 0.008), and the likelihood of positivity in newborns increased by 0.07% (OR = 1.007; 95% CI 1.001 to 1.014; p = 0.026) for each day of COVID‒19 infection during pregnancy closer to birth.
Conclusions
Newborns who tested positive for SARS-CoV-2 were at greater risk of respiratory disorders, and maternal infection closer to birth increased the likelihood of positivity in newborns. There was no association between infection with COVID-19 in newborns and the severity of maternal infection, prematurity, or birth weight.
Ignored or underestimated - Evaluation and treatment of cardiovascular risk factors in patients with adrenal insufficiency Undertreatment of cardiovascular risk factors in patients with adrenal insufficiency
Authors: Wasmuth Anja , de Loo Iris van , Domberg Julia , Harbeck Birgit 
Published: September 2024

Abstract

Purpose
Patients with adrenal insufficiency (AI) are known to have a higher cardiovascular risk (CVR) than the normal population. In particular arteriosclerosis, coronary heart disease, arterial hypertension, hyperlipoproteinemia as well as metabolic disturbances contribute to the increased morbidity and mortality. Aim of this study was to evaluate known CVR factors along with the quality of care by the treating physicians.
Methods
To this end the medical records of AI patients were screened for CVR factors and the treatment initiated was documented. In addition, a questionnaire evaluating CVR factors was analyzed if available.
Results
In total, 327 AI patients were included in the study. At least 298 of these patients were found to have one or more CVR factors. Ninety-one patients were diagnosed with arterial hypertension, of these 40 patients (44%) still showed increased blood pressure (BP) values. Of all AI patients, about 25% (n = 83) did not have measurements to calculate their BMI, even though obesity is known as a major risk factor for cardiovascular events. Out of 46 patients with diabetes, one-quarter still had increased HbA1c values. Regarding hyperlipoproteinemia, only 4% of AI patients achieved normal lipid values across all parameters (n = 12). Interestingly, at least one lipid variable was untested in 150 patients (46%).
Conclusion
Our study demonstrates (1) the high rate of CVR factors in AI patients, leading to increased morbidity and eventually mortality, (2) AI patients are inadequately monitored and treated for CVR factors, (3) treating physicians should be aware of this risk to minimize complications where possible.
Late Lymphocele Infection with Parvimonas micra in a Kidney Allograft Recipient
Authors: Dkhissi Rihab , Ouellet Gabriel , Charmetant Xavier , Buron Fanny , Valour Florent , Rouvière Olivier , Matillon Xavier , Morelon Emmanuel 
Published: September 2024

Abstract

Background
Lymphocele infection is a frequent and usually early complication following renal transplantation. We report the case of a transplanted patient with a chronic lymphocele that became infected six years after transplantation Parvimonas micra, a commensal of the human oral cavity.
Case presentation
: The patient had a stable lymphocele for six years post-transplantation over several medical imaging. Regarding a six-month progressive decline in general condition, a persistent inflammatory syndrome and a deterioration of renal function, a PET scan revealed a hypermetabolic infiltration behind the lymphocele adjacent to the graft. Bacterial superinfection with Parvimonas micra was diagnosed by an exploratory puncture. The patient had a history of dental periodontal treatments. The initial attempt at treatment with radiological drainage and three months of antibiotic therapy was unsuccessful. Faced with radiological deterioration despite treatment, the patient underwent surgical intervention for lavage with necessary antibiotic therapy for an additional six weeks. He achieved clinical remission, but metabolic activity persists within the site of a residual collection, and the patient remains closely observed.
Conclusions
Infected lymphoceles should be considered in the differential diagnosis for patients presenting with nonspecific infectious and inflammatory symptoms, regardless of the time elapsed since renal transplantation. The treatment of this complication can be complex.
The causal relationship between inflammatory cytokines and thrombocytopenia: A bidirectional two-sample Mendelian randomization study
Authors: Hong Kimsor , Hun Marady , Wu Feifeng , Mao Jueyi , Wang Yang , Zhu Junquan , Zhou Xin , Xie Haotian , Li Binbin , Qiu Xinying , Tian Jidong , Zhang Liang , Wen Chuan 
Published: September 2024

Abstract

Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. Epidemiological and experimental evidence has linked inflammation cytokine levels to ITP etiology but is uncertain. To respond to this query, we conducted a Mendelian randomization (MR) analysis to investigate the causal effects of circulating cytokine levels on ITP development. Using summary statistics from genome-wide association studies (GWAS), we obtained data on 41 serum cytokines from 8,293 Finnish individuals and ITP data from a meta-analysis of the FinnGen consortium, UK Biobank, and BioBank Japan. The association between genetically predicted levels of inflammatory cytokines and ITP was estimated using a bidirectional Mendelian randomization (MR) study. Sensitivity analyses and the False Discovery Rate (FDR) method were also performed to verify the robustness of the results. We discovered that higher genetically predicted M-CSF levels were strongly associated with an increased risk of ITP (OR: 1.09; 95%CI: 1.03–1.16; p = 0.003) and gestational thrombocytopenia (GT) (OR: 1.17; 95%CI, 1.05–1.32; p = 0.006). Additionally, our results showed an adverse association between genetically predicted levels of the circulating HGF (OR: 0.75; 95%CI, 0.63–0.90; p = 0.002), MIF (OR: 0.90; 95%CI, 0.84–0.96; p = 0.001) and TRAIL (OR: 0.92; 95%CI, 0.87–0.97; p = 0.003) with the GT. The study result links genetic predisposition to elevated M-CSF levels with increased risks of ITP and GT, suggesting that targeting cytokines could aid in ITP prevention, though further validation is needed.
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Authors: Yan Biao , Ye Fan , Zhang Ziran , Shi Lianjun , Mu Wan , Lu Shuting , Li Xiumiao , jiang qin 
Published: September 2024

Abstract

Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Disruption of this process is implicated in diseases such as cancer, inflammation, and autoimmune disorders. In this study, we elucidate the role of tsRNA-0032 in lymphangiogenesis and its molecular mechanisms. tsRNA-0032 expression is significantly diminished in corneal suture and LPS-induced human lymphatic endothelial cell (HLEC) models under inflammatory conditions. Overexpression of tsRNA-0032 suppresses lymphangiogenesis by inhibiting HLEC proliferation, migration, and tube formation. Moreover, overexpression of tsRNA-0032 inhibits suture-induced mouse corneal lymphangiogenesis in vivo. tsRNA-0032 is mainly found in the cytoplasm and interacts with Ago2 protein. Overexpression of tsRNA-0032 leads to a reduction in ATP production and lowers the levels of pyruvate and lactate by targeting PKM2, which is crucial for the final step of glycolysis. This regulation of glycolysis impacts the cellular energy and metabolic balance in HLECs, contributing to the inhibition of lymphangiogenesis. Clinical data show that tsRNA-0032 levels are markedly lower in corneal tissues from transplant recipients compared to donors, whereas PKM2 expression is elevated, underscoring the clinical significance of the tsRNA-0032/PKM2 axis in corneal lymphangiogenesis. This study provides novel insights into lymphangiogenesis regulation and offers potential therapeutic targets for lymphatic-related diseases.
A Performance-centric Topology for Hybrid Wireless-Network-on-chip
Authors: Rahaman Munshi Mostafijur , Ghosal Prasun , Giri Chandan 
Published: September 2024

Abstract

Wireless Network-on-Chip (WNoCs) has flourished rapidly and successfully in mitigating conventional Network-on-Chips (NoCs) performance constraints. As retaliation, WNoCs initiate a preamble for present-day NoC state-of-the-art to evolve at the cutting edge of scalability and architectural expandability. Reduced latency, broadcast aid, and system-level plainness build on-chip wireless communication , an emerging choice during network-on-chip architecture development. In this work, a hybrid WNoC is designed from a mix of wireless and wired mode NoCs supported by an appropriate routing method and topology scheme. The performance measurement of the proposed WNoC design has been done comparably under distinct types of synthetic traffic patterns and benchmark frameworks concerning throughput, latency, and energy at varied workloads. Examination results of the proposed approach specify a lessening of the average latency up to 88.64% and a reduction of energy up to 90.08% with a significant gain in throughput up to 91.62%.
Medicinal Cannabis Formulations, Administration Routes and Dosing: Perspectives of Adults with Cancer
Authors: Nayak Manan M. , Chai Peter R. , Tung Stephanie , Revette Anna , Braun Ilana M. 
Published: September 2024

Abstract

Introduction: One-of-three or -four adults with cancer turns to medicinal cannabis. Prior work suggests a disconnect between the clinical preferences of oncology teams and the cannabis therapeutics practices of patients. For instance, oncologists favor oral administration, while many cancer patients combust or vaporize. This investigation explored medicinal cannabis (MC) formulations, routes of administration, and dosing preferences among adults with cancer.
Methods: Semi-structured phone interviews across eight states with adults with cancer consuming MC in compliance of state law were conducted and analyzed using applied thematic analysis.
Results: Among study participants (N=24), mean age was 54 years. Sixty-seven percent were female. Forty-six percent resided in the Eastern United States and 51% described their cancer as metastatic or incurable. Across interviews, a powerful theme was of myriad MC product formulations available through a given dispensary storefront, triggering astonishment and sometime feelings of inundation. Common strategies among participants were to purchase and sample multiple store-bought formulations as well as to modify dispensary products at home, at times to alter intended routes of administration or to reduce financial toxicity. A trusted, preferred dispensary product was not always consistently available. Although oral was the top-cited administration mode, the wide array of cannabis consumption methods included topical, sublingual, vaporization, combustion, and rectal suppository. Three-quarters of participants alternated between modes of administration. Medicinal cannabis dosing imprecision constituted another powerful theme, thought to be due to lack of quality assurance at the level of the dispensary and measurement imprecision in the home.
Discussion: This investigation suggests that MC preparations, administration routes and dosing vary dramatically among individuals with cancer; and that the few commonalities in use patterns, for instance reliance on multiple routes of cannabis administration, tend not be rooted in scientific evidence. These qualitative finding should be interrogated quantitatively but indicate that lay-facing educational programs pertaining cannabis therapeutics in the setting of cancer, as well as a higher degree of dispensary product standardization may be warranted.
A Comparative Study of the Seismic Performance of Self-Centering CRBFs and BRBF systems
Authors: Ramadan Mostafa , Abou-Elfath Hamdy , Turkomany Mohab 
Published: September 2024

Abstract

The current seismic design philosophy of building structures relies on the inelastic response of the main structural elements as the principal source for dissipating the seismic energy. The product of this philosophy is considerable levels of residual drifts that could make building structures look unsafe to their occupants. Recently, considerable research efforts were directed toward the invention of self-centering (SC) lateral load-resisting systems that are able to prevent damage in the main structural elements as well as reduce the residual deformations to minimal levels. One of these SC systems is the recently proposed controlled rocking braced frame (CRBF) system. The SC-CRBFs have shown to be a suitable alternative to conventional systems such as buckling-restrained braced frames (BRBFs). This paper performs a comparative study on the seismic performance of SC-CRBFs and BRBF systems. Two prototype buildings having 3- and 6-story are designed using BRBF and SC-CRBF systems. The buildings are subjected to pushover static loading and a suite of earthquake records. The maximum and residual lateral drifts are considered the main performance parameters for the seismic performance evaluation. The findings of this study indicate that the SC-CRBF systems exhibit superior seismic performance in comparison with traditional BRBF systems.
Design of low ripple interleaved parallel switching capacitors bidirectional DC converter based on magnetic integration technology
Authors: Mao Ling , Wang Jian , ZHAO Jinbin 
Published: September 2024

Abstract

To solve the probleµ of large current ripple on the low-voltage side of the interleaved switched capacitor bidirectional converter in the energy storage systeµ, an interleaved parallel switched capacitor bidirectional DC/DC converter based on coupled inductors by using µagnetic integration technology is proposed. the µagnetic core can be effectively shared by integrating the discrete inductors on the low-voltage side of the converter into a coupled inductor, and the coupling coefficient is adjusted to fully utilize the core flux, thereby increasing the inductance value and iµproving the current ripple on the low-voltage side. Based on the analysis of the relationship aµong the inductance value, duty cycle and coupling coefficient under different µodes of the converter, this paper finds the functional relationship between the converter ripple current and the coupling coefficient. The siµulation results show that when the coupling coefficient is greater than 0, the current ripple decreases on the low-voltage side gradually as the coupling coefficient increases. Finally, a 150W experiµental prototype is built for verification. The efficiency of the converter is 91.28%. When the coupling coefficients are 0.15 ,0.63 and 0.82, the current ripple on the low-voltage side was reduced by 9.88%, 37.03% and 44.44%, respectively.
Synthesis, crystal structure, and Hirshfeld surface analysis of (E)-N, N´-ethylene-1,2- diamino-bis (N, N-dimethylbut-2-enamide)
Authors: Ganesan M. , Ayyappan A. , Arockiasamy S. 
Published: September 2024

Abstract

The compound, (E)-N, N´-ethylene-1,2-diamino-bis(N, N’-dimethylbut-2-enamide) was synthesized by a reaction between N, N´-dimethylacetoacetamide and ethylenediamine in a methanolic medium. The Schiff base compound was characterized by infrared (IR) spectroscopy, mass spectrometry (MS), thermogravimetry (TG), and single-crystal X-ray diffraction (XRD). The compound was crystallised in a triclinic crystal system with a space group of P-1. The amine functional group (-C = N-) was confirmed by the band at 1592 cm− 1 in its IR spectrum. The compound is thermally stable from 40–203 oC losing only 1.4% of its weight. The thermogram (TG) indicated the absence of any water of hydration or lattice water. The compound exhibits keto-enol tautomerism with a zwitterionic structure. The major contributors to the Hirshfeld surface (HS) contacts are H—H (71%), O—H (11.7%), and C—H (12.2%). The crystal parameters are, a = 6.3623(4) Å, b = 6.5585(4) (8) Å, c = 10.8135(7) Å, Z = 4, R1 = 0.0610, wR2 = 0.1447. α = 98.16 (4)o, β = 95.86(4)o, γ = 117.63(4)o.
Using a citizen science approach to assess nanoplastics pollution in remote high-altitude glaciers
Authors: Jurkschat Leonie , Gill Alasdair , Milner Robin , Holzinger Rupert , Evangeliou Nikolaos , Eckhardt Sabine , Materić Dušan 
Published: September 2024

Abstract

Nanoplastics are suspected to pollute every environment on Earth and reach very remote areas, e.g. via airborne transport. We approached the challenge of measuring environmental nanoplastics by combining high-sensitivity TD-PTR-MS (thermal desorption-proton transfer reaction-mass spectrometry) with trained mountaineers sampling high-altitude glaciers (“citizen science”). We analysed particles < 1 µm for common polymers (polyethylene, polyethylene terephthalate, polypropylene, polyvinyl chloride, polystyrene and tire wear particles), revealing nanoplastic concentrations ranging from 2–80 ng mL− 1 at five of 14 sites. The major nanoplastic polymer types found in this study were tire wear, polystyrene (PS) and polyethylene (PE) particles (41%, 28% and 12%, respectively). FLEXPART modelling was used to reconstruct possible sources of micro- and nanoplastic emissions for those observations, appearing to lie largely to the west of the Alps, where France, Spain and Switzerland have the highest contributions.
Exercise Intensity of the Traditional Chinese Mind–Body Exercise, Baduanjin, during Performance amongst Beginners
Authors: Shi Mengni , Zhou Xin , Guo Lei , Fang Min , Li Jing Xian , Zhu Qingguang 
Published: September 2024

Abstract

Objective
The traditional Chinese mind–body exercise, Baduanjin, has remained popular for a thousand years for strengthening the body, promoting health and preventing chronic diseases. However, research on its exercise intensity is lacking. This study measured the exercise intensity of beginners practicing Baduanjin to provide scientific evidence for health promotion and exercise prescriptions.
Methods
A total of 20 healthy adults (13 males, 7 females) aged between 35 and 45 years, who had not practiced Baduanjin previously, were recruited. The average METs, HR, HRR, VO2, VO2/kg, VO2/HR, RR, RQ and VE were measured using the Italian Cosmed/K5 wireless portable exercise cardiopulmonary testing system.
Results
The average METs during Baduanjin was 2.92 ± 0.65. The mean maximum and mean average HR were 109.35 ± 17.83 and 95.34 ± 13.99, respectively. During Baduanjin, the exercise intensity indicators showed significant increases (P < 0.001) in VO2, VO2/kg, METs, HR, VO2/HR, RR and VE compared with the resting state. Additionally, the mean RQ increased (P < 0.05).
Conclusion
Baduanjin is a low-intensity exercise for beginners. HR reached its maximum in the later stages of Baduanjin, significantly decreased immediately after exercise and returned to near-resting levels within three minutes post-exercise. Baduanjin, as a low-intensity exercise, could be recommended for population members suitable to practice.
Establishing a cancer cohort in Latin America: The Mexican Teachers Cohort
Authors: Gómez-Flores-Ramos Liliana , Brochier Marion , Stern Dalia , Garcia-Anaya Antonio , Cortés-Valencia Adrian , Jaen Jocelyn , Sánchez-Blas Hugo R. , Lozano-Esparza Susana , Catzin-Kuhlmann Andrés , Hernández-Ávila Juan Eugenio , Pon Angélica , Rivera-Ontiveros Olga , Miranda-Aguirre Pabel , Pérez-Escobedo Patricia , Castellanos Alberto , Chávez-Cárdenas Mildred , Mohar Alejandro , López-Ridaura Ruy , Romieu Isabelle , Hernández-Avila Mauricio , Lajous Martín 
Published: September 2024

Abstract

Purpose
In Latin America, prospective cancer research is restricted by limited access to cancer outcome data. In this study, we demonstrate a strategy for identifying incident breast cancer cases within an established prospective cohort, the Mexican Teachers’ Cohort (MTC), through the use of self-reports, electronic health records (EHRs), administrative databases, and registries.
Methods
The MTC consists of 115,275 female teachers aged 25 years and older who completed a questionnaire on reproductive history, lifestyle, and health between 2006 and 2008. We used self-reported breast cancer, mortality and cancer registries, and EHRs and administrative databases for case ascertainment. Person-time was calculated from the date of baseline questionnaire response to diagnosis, death, or December 31, 2019. We estimated age-specific and age-standardized incidence rates for breast cancer.
Results
We identified 1,313 incident breast cancers; 94% were confirmed through registries and/or databases, and 6% directly by contacting participants. The crude breast cancer incidence was 102 per 100,000 person-years, with the highest incidence in women aged 65–69 (185 per 100,000 person-years). The age-standardized incidence was 77 per 100,000. Over one-third of cases (n = 476) occurred in women younger than 50 years.
Conclusion
The efficient identification of participants with incident breast cancer in the MTC demonstrates that prospective cancer cohorts can be successfully established in Latin America.
Continuous liquid supply multi-material DLP 3D printing
Authors: Wu Lei , Sun Jiawei , Xiong Wangjun , Zhang Lidian , Song Yanlin 
Published: September 2024

Abstract

Digital light processing (DLP) 3D printing has been considered as one of the most sustainable additive manufacturing methods for high-speed and high-resolution construction across various fields. Recent investigations focus on curing surface and resin formation regulation to realize printing continuity. However, heat accumulation from light-curing exotherm is aggravated and multi-material printing is compromised with the realization of printing continuity. Here, we propose a continuous liquid supply 3D printing strategy through introducing supplied liquid into one-droplet 3D printing system. Timely curing of slices can be maintained inside droplet reservoir along with on-demand resin supply, decreased heat accumulation and unlimited printing volume can thus be realized. Additionally, supply species, quantity and distribution are controllable in slices, leading to continuous mode of muti-material printing. Multi-material 3D structures with controllable morphologies and distributions can be prepared with enhanced interfacial mechanical properties and clear boundaries, and has been applied in material distribution defined 3D anti-counterfeiting and magnetic-responsive moving trajectories, which guarantees a high efficiency and sustainable multi-material 3D fabrication route.