bluuebunny/crossref_metadata_2025_split huggingface dataset:
An evaluation of diethylhexyl phthalate free top & bottom in‐line blood collection set with a new soft housing filter
Authors: Danilova Elena , Ezligini Farshid , Stöckel Connie , Asakawa Masafumi , Hetland Geir 
Published: September 2024

AbstractBackground and ObjectivesDi (2‐ethylhexyl) phthalate (DEHP) plasticizer must be removed from polyvinylchloride (PVC) medical devices due to toxicity. DEHP/PVC blood bags were shown to provide stable quality under blood component production and to create good storage conditions for red blood cells concentrate (RBC). It is important that substitution of the DEHP maintains the RBC quality during storage, which should be achieved with Di (isononyl) cyclohexane‐1,2‐dicarboxylate (DINCH), although substitution of the plasticizer has been challenging.Materials and MethodsA DEHP‐free Top & Bottom in‐line RBC set was validated in a tertiary hospital blood bank facility. Volunteer blood donors were randomly allocated for blood collection into DINCH/PVC or DEHP/PVC set. The groups were additionally divided according to additive solution/filter combination: PAGGS‐M + DINCH/PVC filter (only with DINCH/PVC set), and SAG‐M + DINCH/PVC filter and SAG‐M + DEHP/PVC filter (only with DEHP/PVC set). Processing and storage effects were assessed in all components.ResultsRBC concentrates, platelet concentrates and plasma that was processed and stored in DEHP‐free set fulfilled European requirements for quality. The cells stored in PAGGS‐M after filtration through DEHP‐free PVC filter showed the same low haemolysis compared with conventional set at 49 days of storage. Platelets stored in DINCH/PVC bag provided a sufficient quality of platelets after 7 days of storage. Plasma maintained the coagulation factors during 12 months of storage.ConclusionA new DINCH/PVC set allows production of blood components of satisfactory quality in DEHP‐free environment.
The effects of climatic and non-climatic factors on malaria mortality at different spatial scales in western Kenya, 2008–2019
Authors: Nyawanda Bryan O. , Khagayi Sammy , Obor David , Odhiambo Steve B. , Beloconi Anton , Otieno Nancy A. , Bigogo Godfrey , Kariuki Simon , Munga Stephen , Vounatsou Penelope 
Published: September 2024

BackgroundMalaria mortality is influenced by several factors including climatic and environmental factors, interventions, socioeconomic status (SES) and access to health systems. Here, we investigated the joint effects of climatic and non-climatic factors on under-five malaria mortality at different spatial scales using data from a Health and Demographic Surveillance System (HDSS) in western Kenya.MethodsWe fitted Bayesian spatiotemporal (zero-inflated) negative binomial models to monthly mortality data aggregated at the village scale and over the catchment areas of the health facilities within the HDSS, between 2008 and 2019. First order autoregressive temporal and conditional autoregressive spatial processes were included as random effects to account for temporal and spatial variation. Remotely sensed climatic and environmental variables, bed net use, SES, travel time to health facilities, proximity from water bodies/streams and altitude were included in the models to assess their association with malaria mortality.ResultsIncrease in rainfall (mortality rate ratio (MRR)=1.12, 95% Bayesian credible interval (BCI): 1.04–1.20), Normalized Difference Vegetation Index (MRR=1.16, 95% BCI: 1.06–1.28), crop cover (MRR=1.17, 95% BCI: 1.11–1.24) and travel time to the hospital (MRR=1.09, 95% BCI: 1.04–1.13) were associated with increased mortality, whereas increase in bed net use (MRR=0.84, 95% BCI: 0.70–1.00), distance to the nearest streams (MRR=0.89, 95% BCI: 0.83–0.96), SES (MRR=0.95, 95% BCI: 0.91–1.00) and altitude (MRR=0.86, 95% BCI: 0.81–0.90) were associated with lower mortality. The effects of travel time and SES were no longer significant when data was aggregated at the health facility catchment level.ConclusionDespite the relatively small size of the HDSS, there was spatial variation in malaria mortality that peaked every May–June. The rapid decline in malaria mortality was associated with bed nets, and finer spatial scale analysis identified additional important variables. Time and spatially targeted control interventions may be helpful, and fine spatial scales should be considered when data are available.
Effects of a combined exercise and dietary intervention on clinical outcomes in patients with ovarian cancer: the Physical Activity and Dietary intervention in OVArian cancer (PADOVA) randomized controlled trial
Authors: Brouwer Calvin G , Hartman Yvonne A W , Stelten Stephanie , Kenkhuis Malou-Floor , van Lonkhuijzen Luc R C W , Kenter Gemma G , Kos Milan , van de Ven Peter M , Driel Willemien J van , Winkels Renate M , Bekkers Ruud L M , Ottevanger Petronella B , Hoedjes Meeke , Buffart Laurien M 
Published: September 2024

ObjectiveChemotherapy treatment modifications can impact survival in patients with ovarian cancer, particularly when the relative dose intensity falls below 85%. Exercise and dietary interventions may benefit treatment tolerability. This study aimed to explore the effects of a combined exercise and dietary intervention on secondary outcomes of the Physical Activity and Dietary intervention in OVArian cancer (PADOVA) trial, specifically relative dose intensity and progression-free survival.Methods81 patients with ovarian cancer were randomized into a combined supervised exercise and dietary intervention during (neo)adjuvant chemotherapy or a usual care control group. Relative dose intensity was calculated as the ratio of delivered dose intensity (dose per actual time) to the standard dose for six chemotherapy cycles. The effect on relative dose intensity was analyzed using logistic regression and Bayesian posterior probability of correctly identifying the best study arm. The effect on progression-free survival was examined using Cox regression.ResultsThe proportion of patients achieving a relative dose intensity ≥85% was 74.4% in the intervention group compared with 61.5% in the control group (OR 2.04, 95% CI 0.75 to 5.84). The Bayesian posterior probability that the intervention group had a higher proportion of patients with a relative dose intensity ≥85% was 88.4%. Intervention effect on progression-free survival was not statistically significant (HR 1.63, 95% CI 0.82 to 3.23). At 18 months, the proportion of patients without disease progression was 73% in the intervention group and 51% in the control group.ConclusionThe proportions of patients with ovarian cancer with a relative dose intensity ≥85% and an 18-month progression-free survival were numerically higher in the intervention group compared with the control group, but these differences were not statistically significant. The higher proportions and the 88.4% probability that intervention is superior to usual care for clinical outcomes support future studies on exercise and dietary interventions with a focus on clinical outcomes as primary endpoints.Trial registration numberRegistered in the Netherlands Trial Registry (NTR6300).
Novel scoring system incorporating lipoproteins to predict outcomes of epithelial ovarian cancer patients
Authors: Tang Song , Zheng Fang , Chen Kelie , Niu Yizhen , Fu Zhiqin , Wu Yihua , Xia Dajing , Lu Weiguo 
Published: September 2024

ObjectiveEpithelial ovarian cancer is the most lethal gynecological malignancy worldwide. While common prognostic factors are identified, the impact of serum lipoproteins remains controversial. This retrospective cohort study aims to investigate the association between specific lipoprotein levels and prognosis.MethodsClinical data of 420 participants with epithelial ovarian cancer registered at Women’s Hospital, School of Medicine, Zhejiang University, between January 2014 and April 2021 were included. Cox regression analyses and Kaplan–Meier methods were used to assess prognosis, estimated by hazard ratio (HR) with 95% confidence interval (CI). A novel prognostic model incorporating lipoproteins was developed for evaluating the prognosis. Meta-analysis was applied to assess the impact of low density lipoprotein cholesterol (LDL-C) on prognosis.ResultsAmong 420 patients, those in advanced stages exhibited higher low density lipoprotein cholesterol (LDL-C) (p=0.008) and lower high density lipoprotein cholesterol (HDL-C) levels (p<0.001), with no significant differences in total cholesterol or triglyceride levels. Elevated LDL-C level was significantly associated with worse overall survival (HR 1.72; 95% CI 1.15 to 2.58; p=0.010) and progression free survival (HR 1.94; 95% CI 1.46 to 2.58; p<0.001), whereas higher HDL-C level was linked to better overall survival (HR 0.56; 95% CI 0.37 to 0.85; p=0.004) and progression free survival (HR 0.61; 95% CI 0.46 to 0.81; p<0.001). A novel prognostic model, low density lipoprotein cholesterol-high density lipoprotein cholesterol-fibrinogen-lactate dehydrogenase-prealbumin-Fe-stage (LH-FLPFS), was established to enhance prognostic predictive efficacy. The meta-analysis further suggested that higher LDL-C level was associated with worse overall survival (HR 1.82; 95% CI 1.39 to 2.38; p<0.001).ConclusionsIn this study, preoperative LDL-C and HDL-C levels emerged as potential prognostic factors for ovarian cancer. Establishment of a novel prognostic model, LH-FLPFS, holds promise for significantly improving prognostic predictive efficacy.
Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade
Authors: Mei Jie , Chu Jiahui , Yang Kai , Luo Zhiwen , Yang Jiayue , Xu Junying , Li Qing , Zhang Yan , Zhang Qinglin , Wan Mengyun , Xue Ningyi , Ding Junli , Zhu Yichao , Cai Yun , Yin Yongmei 
Published: September 2024

BackgroundImmune checkpoint blockade (ICB) has made remarkable achievements, but newly identified armored and cold tumors cannot respond to ICB therapy. The high prevalence of concomitant medications has huge impact on immunotherapeutic responses, but the clinical effects on the therapeutic outcome of armored and cold tumors are still unclear.MethodsIn this research, using large-scale transcriptomics datasets, the expression and potential biological functions of angiotensin II receptor 1 (AGTR1), the target of angiotensin receptor blocker (ARB), were investigated. Next, the roles of ARB in tumor cells and tumor microenvironment cells were defined by a series of in vitro and in vivo assays. In addition, the clinical impacts of ARB on ICB therapy were assessed by multicenter cohorts and meta-analysis.ResultsAGTR1 was overexpressed in armored and cold tumors and associated with poor response to ICB therapy. ARB, the inhibitor for AGTR1, only suppressed the aggressiveness of tumor cells with high AGTR1 expression, which accounted for a very small proportion. Further analysis revealed that AGTR1 was always highly expressed in cancer-associated fibroblasts (CAFs) and ARB inhibited type I collagen expression in CAFs by suppressing the RhoA-YAP axis. Moreover, ARB could also drastically reverse the phenotype of armored and cold to soft and hot in vivo, leading to a higher response to ICB therapy. In addition, both our in-house cohorts and meta-analysis further supported the idea that ARB can significantly enhance ICB efficacy.ConclusionOverall, we identify AGTR1 as a novel target in armored and cold tumors and demonstrate the improved therapeutic efficacy of ICB in combination with ARB. These findings could provide novel clinical insight into how to treat patients with refractory armored and cold tumors.
Intratumoral CXCL13+CD160+CD8+T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer
Authors: Wang Jiawei , Liang Yuan , Xue Ao , Xiao Jian , Zhao Xinyu , Cao Shuqing , Li Pengyu , Dong Jiacheng , Li Yuan , Xu Zekuan , Yang Li 
Published: September 2024

BackgroundStage IV gastric cancer is a highly heterogeneous and lethal tumor with few therapeutic strategies. The combination of programmed cell death protein 1 inhibitors and chemotherapy is currently the standard frontline treatment regimen for advanced gastric cancer. Nevertheless, it remains a great challenge to screen the beneficiaries of immunochemotherapy and expand indications for this treatment regimen.MethodsWe conducted a pathological assessment to ascertain the importance of tertiary lymphoid structures based on the tissue samples collected from patients with stage IV gastric cancer (n=15) both prior to and following immunochemotherapy treatment. Additionally, we used spatial (n=10) and single-cell transcriptional analysis (n=97) to investigate the key regulators of tertiary lymphoid structures (TLSs). Multiplex immunofluorescence and image analysis (n=34) were performed to explore the association between tumor-infiltrating CXCL13+CD160+CD8+T cells and TLSs. The relationship between CXCL13+CD160+CD8+T cells and the responsiveness to immunotherapy was also evaluated by multiplex immunofluorescence and image analysis approaches (n=15). Furthermore, we explored the intrinsic characteristics of CXCL13+CD160+CD8+T cells through various experimental techniques, including quantitative reverse transcription-PCR, western blot, and flow cytometry.ResultsWe found that responders exhibited higher levels of TLSs and CXCL13+CD160+CD8+T cells in biopsy tissues prior to immunochemotherapy compared with non-responders. Following conversion therapy, responders also had a higher percentage of mature TLSs and a higher number of CXCL13+CD160+CD8+T cells in surgical resections. Moreover, we discovered that vitamin B6in CD160+CD8+T cells could reduce the ubiquitination modification of HIF-1α by MDM2, thereby attenuating the degradation of HIF-1α. Consequently, this led to the transcriptional upregulation of CXCL13 expression, facilitating the recruitment of CXCR5+B cells and the formation of TLSs.ConclusionThe number and maturity of TLSs, along with the extent of CXCL13+CD160+CD8+T-cell infiltration, might function as potential indicators for assessing the effectiveness of immunotherapy in treating gastric malignancies. Furthermore, our research suggests that vitamin B6could enhance the secretion of CXCL13 by CD160+CD8+T cells by reducing the degradation of HIF-1α. Additionally, we demonstrate that vitamin B6supplementation or targeting pyridoxal kinase could substantially improve the efficacy of immunotherapies for gastric cancer.
“National Sovereignty”: Problems of Defining the Concept and Content of Artistic Consciousness in the Republic of Kazakhstan
Authors: Ospanova Rysgul , Ishpekbayev Zhanatbek , Ospanova Bayandy , Shulanbekova Gulzhanar , Shakharman Gulzhihan 
Published: September 2024

Abstract
This article examines the concept of national sovereignty – the right of a nation to self-determination and autonomy. Drawing on the theories of popular sovereignty and social contract, the authors trace how the idea emerged that nations united by identity could claim legitimate political authority over themselves. A key milestone was the Peace of Westphalia in 1648, which codified the territorial sovereignty of nation-states. The authors analyse how eighteenth- and nineteenth-century nationalism transformed national sovereignty into a powerful force fuelling revolutions and movements against foreign domination. It explores how national sovereignty was exercised through the historical examples of France, Germany and the formation of a sovereign Kazakhstan after the collapse of the Soviet Union. While national sovereignty is based on self-determination, its exercise has led to both the assertion of independence and ethnic conflict and confrontation over national identity. The article concludes with an assessment of how theories of national sovereignty continue to emphasize autonomy and self-governance, but must be balanced with contemporary international norms and a system of global interdependence. National sovereignty remains one of the basic tenets underlying the nation-state system.
Made by the Hands of God: Human Dignity in Hilary of Poitiers’s Exegesis of Ps 118:73a LXX
Authors: Contini Sara 
Published: September 2024

Abstract
In his commentary on Psalm 118(LXX):73a, “Your hands made me and fashioned me” (Tract.118Ps. 10.1–8), Hilary of Poitiers provides a unique perspective on the creation of humanity and on its exceptional dignity. I will examine key aspects of Hilary’s exegesis of this verse, namely, the identification of the hands of God, the interpretation of the two verbs “made” and “fashioned”, and the connections with Genesis 1:26 and 2:7. I will also compare Hilary’s interpretation of Ps 118:73a to the views expressed by other authors such as Theophilus, Irenaeus, Origen, Tertullian, Ambrose, and Didymus, with the purpose of contextualising Hilary’s novel understanding of human dignity within the larger framework of Early Christian interpretations of Genesis.
Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study
Authors: Salo E. , Roche D. , Gomez-Martinez V.B. , Cruz-Domenech J.M. , Garcia-Mora L.G. , Gabernet-Castello C. , Freixenet N. 
Published: September 2024

Abstract
Treatment with probiotics can help manage chronic constipation by softening the stools and possibly acting synergistically with front-line treatments. We assessed the efficacy of Bifidobacterium animalis subsp. lactis BLa80 in maltodextrin as a food supplement in regulating the intestinal habit of subjects with chronic constipation with type 1 or 2 stools on the Bristol scale index and/or less than three stools per week. A multicentre, randomised, double-blind, placebo-controlled clinical trial was carried out in subjects aged 18 and over with chronic constipation. The study enrolled forty-six subjects who were randomised one-to-one to receive the potential probiotic in maltodextrin (n = 23) or a placebo (n = 23). Investigators assessed changes in intestinal habits by analysing the mean number of weekly stools and the stool types according to the Bristol Scale. Patients reported constipation symptoms with PAC-SYM (patient assessment of constipation – symptoms), and the impact on quality of life with PAC-QoL (patient assessment of constipation – quality of life) and GI-QLI (gastrointestinal quality of life index). Patients on the intervention group showed a greater tendency to normalise the type of stools than those in the placebo group. This difference towards regular stool types (type 3 and 4) was statistically significant at weeks 8 and 12 relative to week 4 (P-values = 0.006 and 0.027, respectively). The proportion of constipated patients in the experimental group dropped over time, while the rate slightly increased in the placebo group in a statistically significant manner at week 12 relative to week 4 (). Overall, the present study shows oral intake of B. animalis subsp. lactis BLa80 in maltodextrin for 12 weeks improves intestinal habits in subjects with chronic constipation. Our study provides evidence to the efficacy and safety use of this formulation as an effective tool for improving stool consistency in constipated patients.
The trial was registered at ClinicalTrials.gov: NCT05980988.
Subliminal Stimuli Generated in Films through Successive Frames: A Quantitative Assessment
Authors: Sanz-Aznar Javier , Caballero-Molina Juan José , Tarragó-Mussons Anna , Rey-Benito Endika , Consuegra-Fernandez Marta 
Published: September 2024

Abstract
Although numerous theoretical references have been made to subliminal stimuli in filmmaking, no quantitative studies to date have sought to specify their temporal limits. Since the 1920s, several filmmakers have aimed to elicit an emotional impact on the viewer through the inclusion of isolated frames, which supposes the minimum possible temporal extension in films. Through two experiments, this study analysed the threshold between subliminal and supraliminal stimuli in films containing potential subliminal stimuli comprising one to four frames, played at frame rates of 25, 30, and 60 frames per second. The first experiment involved asking participants to view a film excerpt, including these stimuli, and then answer a survey. The second required participants to identify potentially subliminal stimuli whilst viewing a film clip. The stimuli analysed could not be defined as subliminal for 100% of viewers for any number of frames per frame rate, but were predominantly unidentified for one-frame stimuli in films played at 24 or 30 frames per second, and one- to three-frame stimuli in films played at 60 frames per second. Furthermore, three- and four-frame stimuli at 24 and 30 frames per second were found to be supraliminal, whilst the results for two-frame stimuli played at 24 or 30 and four-frame stimuli played at 60 frames per second were inconclusive. Future research is needed to analyse the effect of the nature of the image used as a stimulus and its location within a shot or in a cut between shots.
The Inner Reformation of Reformational Philosophy: Responses to Geertsema and Van Woudenberg
Authors: Zuidervaart Lambert 
Published: September 2024

Abstract
This article responds to reviews of my recent books by Henk Geertsema and René van Woudenberg. First, it explains the method of critical retrieval and reviews my criticisms of Herman Dooyeweerd on the topics of religious antithesis and transcendental critique. Next, I take up questions concerning my social philosophy, epistemology, and conception of truth. Then, in an appendix, I respond to Geertsema’s allegations that I have misunderstood Dooyeweerd. Throughout, the article shows how my work aims to contribute to the inner reformation of Reformational philosophy.
“Surging Tide at Dusk”: Translingual Poetics between Italy and Australia
Authors: Loda Alice 
Published: September 2024

Abstract
This study delves into the realm of translingual poetics by examining the works of two Italian-Australian authors: Paolo Totaro and Enoe Di Stefano. Having migrated to Australia at different times—Di Stefano in 1949 and Totaro in 1963—both authors have developed remarkable literary paths that foreground their ability to move fluidly across different languages and cultures. This research adds to the ongoing critical discourse surrounding the relational and transformative nature of translingual writing, which has gained increasing recognition in literary scholarship. More specifically, this study aims to make theoretical-critical contributions in two key areas. First, it seeks to advance the discussion on literary translingualism in settler colonial contexts, and specifically in the Australian one. Second, it aims to further explore the translingual trajectory that historically permeates the landscape of Italophone and Australian literatures. This contribution aims to advance the analysis of the generative potential of translingual dynamics within the poetic field and across a transnational and transcultural trajectory.
Writing about Dutch Migration to Australia: Language, Belonging, and Identity
Authors: van Beukering Jorien 
Published: September 2024

Abstract
Australia has a long history of linguistic contact with the Netherlands and the Dutch language dating from the 1600s. After the Second World War some 160,000 Dutch-speaking migrants settled in Australia from the Netherlands and the Dutch East Indies. This article examines Dutch migrants’ personal stories of migration to Australia in the second half of the twentieth century and interrogates authors’ usage of the Dutch and English languages in their writing. By examining three Dutch-Australian publications that reflect on twentieth-century migration journeys—Theodora Biesheuvel’s Dutch Treat: For All Those Who Left Their History Behind Them (2014); Corry, Pierre, and Peter de Haas’s Finding Our Place in the Sun: A True Story (2021); and the collection Our Story: Experiences of the Dutch in Queensland (2001), edited by Rob-Jan Mijnarends and Annelies Zeissink—this article investigates how these writers negotiate belonging and identity in multilingual and multicultural Australia through their use of the Dutch and English languages in their writing.