bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the Therapeutic Potential of Small Molecule of SVAK-12: A Comprehensive In Silico, In Vitro, and In Vivo Studies on its Neuroprotective Effects and Molecular Interactions in Parkinson's Disease
Authors: Kokabi Shayesteh , Amiri Mobina , Alahdad Niloofar , Yazdanpanah Mohammad Ali , Shahbazi Ali , Barati Mahmood , Simorgh Sara , Azedi Fereshteh , Angaji Seyed Abdolhamid , Tavakol Shima 
Published: October 2024

Introduction:
Parkinson's disease (PD) is a neurodegenerative disorder associated
with a progressive loss of dopaminergic cells and as of now, there is no established
definitive treatment available for this condition.

Method:
In this study, the focus was on investigating the impact of SVAK-12, a small
molecule that can cross the blood-brain barrier and remain stable without structural
changes. The effect of SVAK-12 was investigated in vitro on neurotoxicity, in vivo model
of Parkinson's Diseases and in silico.

Result:
Through in vitro and in vivo experiments, as well as molecular docking simulations,
it was found that SVAK-12 (375 ng.ml) led to increased cell viability, reduced cellular
damage, and decreased production of NO and ROS. Additionally, it boosted levels
of important neurotrophic factors like BDNF (130.49%) and GDNF (116.38%), potentially
aiding in alleviating motor disability and depression. The study also highlighted
SVAK-12's potential as a therapeutic candidate for neurological disorders due to its ability
to increase tyrosine hydroxylase expression and dopamine levels (4.84 times). While
it did not significantly improve motor symptoms in vivo, it did enhance motor asymmetry
in the forelimbs and gene expression related to brain regions. Besides, it induced significant
BMP-2 gene expression in substantial nigra regions without significant changes
in GDNF and Nurr1 gene expression in the striatum expression. The docking of
SVAK-12, Levodopa, Amantadine, Biperiden, Selegiline, and Rasagiline to the binding
site of GFRα1, sortilin, and TrkB showed that SVAK-12 had greater MolDock score
than Selegiline and Amantadine for GFRα1 and greater than amantadine for Sortilin and
TrKB.

Conclusion:
Overall, the study suggests that SVAK-12's neuro-biocompatibility, ability
to reduce free radicals, and enhanced neurotrophic factors make it a promising candidate
as a neuroprotective drug.
Effects of the Amyotrophic Lateral Sclerosis-related Q108P Mutation on the Structural Ensemble Characteristics of CHCHD10
Authors: Alici Hakan , Uversky Vladimir N. , Kang David E. , Woo Junga Alexa , Coskuner-Weber Orkid 
Published: October 2024

Introduction:
The Q108P pathological variant of the mitochondrial Coiled-Coil-Helix--
Coiled-Coil-Helix Domain-Containing Protein 10 (CHCHD10) has been implicated in amyotrophic
lateral sclerosis (ALS). Both the wild-type and CHCHD10Q108P proteins exhibit intrinsically disordered
regions, posing challenges for structural studies with conventional experimental tools.

Methods:
This study presents the foundational characterization of the structural features of
CHCHD10Q108P and compares them with those of the wild-type counterpart. We conducted multiple
run molecular dynamics simulations and bioinformatics analyses.

Results:
Our findings reveal distinct differences in structural properties, free energy surfaces, and
the outputs of principal component analysis between these two proteins. These results contribute
significantly to the comprehension of CHCHD10 and its Q108P variant in terms of pathology, biochemistry,
and structural biology.

Conclusion:
The reported structural properties hold promise for informing the development of
more effective treatments for ALS.
Anthelmintic Effect of Biosynthesized Silver Nanoparticles of the Momordica dioica Fruit Extract
Authors: N Pruthvi , T Muthukumaran , E Akila , Gurung Pawan Kumar , Narayanaswamy V B 
Published: October 2024

Background:
Momordica dioica belongs to the family Cucurbitaceae and is generally
known as teasle gourd or spiny gourd. This plant is highly significant for its active phytoconstituents
bearing several pharmacological activities.

Objectives:
This study aims to evaluate the anthelmintic activity of biosynthesized Silver nanoparticles
of Momordica dioica fruit extract against Pheretima Posthuma.

Methods:
Momordica dioica silver nanoparticles were prepared by green synthesis and were
characterized using spectroscopic methods like UV-visible, FTIR, and Scanning Electron Microscopy
(SEM) techniques. The prepared silver nanoparticles were investigated for the targeted activity
using Albendazole as standard and normal saline as the control.

Results:
The UV-visible spectrophotometer showed absorbance in the range of 424 nm. FTIR
revealed the presence of functional groups of both extract and nanoparticles. The spherical shape
of the AgNPs and their size ranges below 100 nm by SEM. The In-vitro anthelmintic activity
showed the paralysis and mortality rate of the worms for the fruit extract, and silver nanoparticles
were found to be 45.03±0.1, 60.13±0.1, and 12.35±0.04, 22.34±0.02 by One way ANOVA (p
<0.0001).

Conclusion:
The fruit extract converted to silver nanoparticles had better anthelmintic activity
compared to the fruit extract. The paralysis and death time were reduced 4 to 5 times, which
showed the improved effect of the silver nanoparticles of Momordica dioica extract.
La epopeya republicana de España en la obra de Almudena Grandes
Authors: Angulo Sablina 
Published: October 2024

Almudena Grandes (1960 -2021) reconocida escritora española, merecedora del Premio Nacional de Narrativa (2018) nos ha legado extraordinarias obras de ficción que incluyen historias reales en base a un gran trabajo de documentación. Entre sus obras, en las que vincula sociología, política, historia y literatura, destaca “El corazón helado”, novela que narra el conflicto social en España, no resuelto aún, como consecuencia del golpe de estado contra el gobierno republicano, en 1936. Todo este engranaje en narrado, literariamente, en el romance entre Álvaro Carrión y Raquel Fernández. Él, Álvaro, hijo de un aventurero que se alistó en el destacamento español, “División Azul”, para apoyar a Hitler en la invasión a la Unión Soviética y que, como muchos franquistas en la posguerra, se hiciera de una gran fortuna apropiándose de los bienes y propiedades de familias republicanas. Ella, Raquel, nieta de republicanos vejados por el franquismo y refugiados en Francia, país en el que lucharían contra el nazismo en la Segunda Guerra Mundial.
On the physical-mechanical and tribotechnical properties of antifriction carbon fiber based on a modified thermosetting matrix
Authors: Dvoryantsev D. D. , Lishevich I. V. , Sargsyan A. S. , Savelov A. S. , Sharko E. A. 
Published: October 2024

The physical-mechanical and tribological properties of anti-friction carbon fiber plastic UGET based on low-modulus carbon fabric “Ural T-15R” have been studied in order to increase the magnitude of the ultimate deformation and reduce the elastic modulus through the use of a modified thermosetting matrix ET-4 instead of the traditionally used ET-2.Modes of polymerization and of heat treatment of epoxy binders were selected considering the results of the experiments. Prototypes of prepregs were obtained by solution impregnation on the UPST-1000M line and then processed into PCM by hot pressing. Laboratory samples were made and physical and mechanical tests were carried out to determine the ultimate strength under compression, shear and bending stress under destruction, as well as Charpy impact strength. Steel 20Kh13 and oxidized titanium alloy PT-3V were used as counter body rollers to determine carbon fiber tribosets.It was shown that carbon fiber samples based on chemically modified binder ET-4 with two-stage polymerization and heat treatment mode in the range of 90°C to 180°C both have better physical-mechanical and tribotechnical properties, in contrast with the analogue with a three-stage mode and carbon fiber carbon heat at friction over 20Kh13 steel and oxidized titanium alloy PT-3V.
The Effect of Student Perceptions of the Teaching Profession on Interest in Become a Teacher (Study on Teaching Campus Teaching Students at Padang State University)
Authors: Latifah Ummi 
Published: October 2024

This study is motivated by the results of the author's observations which show that the lack of interest in becoming a teacher in Teaching Campus students at Padang State University is suspected to be one of the factors causing it, namely students' perceptions of the teaching profession. The purpose of this study is to describe the description of student perceptions of the teaching profession and interest in becoming a teacher (Study on Teaching Campus Students at Padang State University) and to determine the effect of student perceptions of the teaching profession on interest in becoming a teacher (Study on Teaching Campus Students at Padang State University). This research is quantitative ex post facto. The population of this study were Teaching Campus Students of Batch 6, State University of Padang, totaling 187 people whose samples were 72 students using the Proportional Stratified Random Sampling technique. The data collection instrument uses a Likert scale measurement model questionnaire which has been tested for validity and reliability. Students' perceptions of the teaching profession are categorized as quite good with an average achievement level of 85.1% of the ideal score. Interest in becoming a teacher is good with an average achievement level of 75.2% of the ideal score. Data were analyzed using simple linear regression test. The test results show that the significance value obtained is <0.000 smaller than 0.05. The results of hypothesis testing show that there is a significant influence between the two variables with a correlation coefficient of 0.223, a correlation significance test of 3.699, and a coefficient of determination (R²) obtained an R² value of 0.164. This shows the effect of interpersonal communication on member performance is 16.4% with the remaining 83.6% influenced by other factors.
PARTISIPASI POLITIK MASYARAKAT DALAM PEMILIHAN KEPALA DESA PENGUJAN KECAMATAN TELUK BINTAN KABUPATEN BINTAN TAHUN 2022
Authors: Safriya Hastika Riza 
Published: October 2024

Abstrak
Hal menarik dari pemilihan kepala desa tersebut masyarakat aktif dalam kegiatan pemberian suara (voting) berbanding terbalik dengan keikutsertaan dalam kegiatan-kegiatan pemilihan kepala desa yang lain. Masyarakat cenderung apatis terhadap isu politik dengan rasa ingin tahu yang sedikit sehingga mayoritas hanya aktif sebagai pemberi suara saja. Penelitian ini bertujuan untuk mengetahui partisipasi politik masyarakat dengan menggunakan teori Abramson dan Hardwick. Penelitian ini menggunakan metode deskriptif kualitatif dengan menggunakan teknik pengumpulan data wawancara dan dokumentasi. Hasil penelitian ini sebagai berikut : a.) Partisipasi politik masyarakat melalui pemberian suara (voting) dengan tingkat kehadiran ke TPS 85 persen, pemilih menggunakan hak pilih karena dua faktor pertama kesadaran politik masyarakat, faktor kedua kepercayaan politik masyarakat. b.) Partisipasi politik masyarakat melalui kegiatan kampanye, ketidakikutsertaan masyarakat pemilih dalam kegiatan kampanye karena sakit dan tidak mengetahui jadwal kampanye berarti kurang sosialisasi tentang jadwal kampanye kepada pemilih sehingga pemilih tidak mengikuti kegiatan kampanye tersebut. c.) Partisipasi politik masyarakat melalui membentuk dan bergabung dalam kelompok kepentingan dalam hal ini tim sukses tidak ada kejelasan data jumlah anggota tim sehingga kegiatan tim sukses tidak ada catatan di lapangan.

Kata Kunci: Partisipasi Politik; Masyarakat; Pemilihan Kepala Desa.

Abstract
The interesting thing about the village head election is that the community is active in voting activities in contrast to participation in other village head election activities. People tend to be apathetic towards political issues with little curiosity so that the majority are only active as voters. This study aims to determine community political participation using Abramson and Hardwick's theory. This research uses descriptive qualitative method by using interview and documentation data collection techniques. The results of this research are as follows: a.) Community political participation through voting with an attendance rate to the polling station of 85 percent, voters use voting rights because of the first two factors of public political awareness, the second factor of public political trust. b.) Community political participation through campaign activities, the non-participation of voters in campaign activities due to illness and not knowing the campaign schedule means less socialization of the campaign schedule to voters so that voters do not participate in the campaign activities. c.) Community political participation through forming and joining interest groups in this case the success team there is no clear data on the number of team members so that the activities of the success team have no records in the field.

Keywords: Political Participation; Community; Village Head Election.
Keamanan Manusia dalam Perdagangan Manusia: Analisis Peran IOM Menangani Human Trafficking
Authors: Sofjan Noorwahid 
Published: October 2024

Abstract
The most crucial thing about human trafficking is that the activity does not disappear and even continues to show increasing numbers of victims. Handling cannot be carried out only by the government or by state officials but requires comprehensive handling from all levels of society. This research aims to highlight the role of an organization in dealing with these problems using a human security approach. Descriptively and qualitatively the facts are analyzed and produce several conclusions: a). efforts to help, defend, rescue based on existing laws which are more outward in nature, but also on efforts to implement human rights values ​​from within. Apart from being an ethical basis, human values ​​are also implemented in every action. b). The problem of human trafficking cannot be separated from structural dimensions such as the fulfillment of welfare, justice and development policies which influence all dimensions of human livelihood. c). The best prevention is through education, providing employment opportunities, welfare and the most important thing is to provide a sense of security for all citizens.
Die Effekte einer Lohnnebenkostensenkung für die Volkswirtschaft und die Wettbewerbsfähigkeit
Authors: Berger Johannes , Strohner Ludwig 
Published: October 2024

Abstract
The tax and social contribution ratio in Austria is very high by European standards, taxes on income in particular. This is reflected in a very wide tax wedge between labour costs and net income. The particularly high inflation in Austria in recent years has led to high wage increases and a loss of competitiveness. Based on a model analysis, it is shown that a reduction of taxes on the wage-sum by 1.4 % of GDP dampens the development of wage costs and increases employment by around 0.9 % or 40,000 persons. In addition, the reform reduces the GDP deflator by 0.9 to 0.7 percentage points and implies an increase in the real export volume by 1.4 % in the first three years.
Bedeutung und Charakteristika der im österreichischen Außenhandel tätigen Firmen
Authors: Dachs Bernhard , Stehrer Robert 
Published: October 2024

Abstract
Austria's prosperity depends to a large extent on exports. The proportion of internationally active companies in the Austrian manufacturing industry has increased steadily in recent years. Exporting companies are on average larger, more productive, pay higher wages and salaries and invest more than companies that do not export. A small group of very export-oriented companies is responsible for a large part of Austria's export volume.
Der Standort Österreich aus Sicht der ökonomischen Komplexität
Authors: Klimek Peter 
Published: October 2024

Abstract
Economic complexity indicators attempt to map latent factors for long-term growth. In this analysis, we shed light on Austria as a business location using multidimensional complexity indicators that allow statements to be made about regional specialization, key technologies for the green transition and individual sectors such as the semiconductor industry. Austria usually occupies top international positions or is at least among the leaders, and this has remained stable over the last 20 years. This implies extensive opportunities for diversification into promising technologies. For individual brown industries, however, there is a risk of getting locked into products whose demand will decline in the course of the green transition.
Die Wichtigkeit von Investitionen und Innovationen für den Wirtschaftsstandort
Authors: Köppl-Turyna Monika , Graf Nikolaus 
Published: October 2024

Abstract
Investment is a prerequisite for innovation and technological progress. Investment activity in Austria is currently well below the average of the eurozone countries. In view of a decline in the relative competitive position as a result of restrained investment activity, the question of economic policy measures to improve innovation and investment activity arises. The economic literature identifies a number of factors that can have a positive influence on investment and innovation. These include, in particular, access to cheap capital, improvements in the education system to promote human capital, the reduction of bureaucratic obstacles and a reduction of taxation and public debt.
Standortnachteil Arbeitskräftemangel: Österreich braucht eine umfassende Fachkräfteoffensive
Authors: Bonin Holger 
Published: October 2024

Abstract
Shortages of skilled workers are now widespread on the Austrian labor market. This results in serious locational disadvantages such as rising labor costs and a lack of personnel to develop and make use of innovations. Austria should therefore launch a comprehensive skilled labor campaign soon. This should correct the framework conditions that currently hinder satisfactory labor market integration of women, older people and migrants, as well as improve employee mobility, since productivity reserves can be leveraged through better job matches.
Potencial terapêutico de fitoconstituintes da Dimorphandra gardneriana Tulasne e Anacardium occidentale L. na Doença de Alzheimer
Authors: Rocha Francisco das Chagas Sousa , Nascimento José Gustavo Queiroz do , Coelho Izadora Alves , Miranda João Antônio   Leal de 
Published: October 2024

Objetivo: Analisar o potencial terapêutico da Dimorphandra gardneriana Tulasne e Anacardium occidentale L. na Doença de Alzheimer (DA) e os possíveis mecanismos de ação envolvidos. Métodos: Trata-se de uma revisão integrativa da literatura, sendo realizada buscas nas bases de dados: Medline/ PubMed, Lilacs, Embase, Cochrane e Scopus. Ademais, foram incluídos artigos em inglês, estudos primários, in vivo, publicados no período de 2003 a 2023. Resultados: Foram selecionadas 19 publicações que investigaram os efeitos dos fitoconstituintes rutina, troxerrutina, quercetina e isoquercitrina presentes na D. gardneriana Tu. no tratamento da DA em ratos ou camundongos. Observou-se que essas substâncias promoveram redução do estresse oxidativo, da neuroinflamação, da síntese de β-amiloide (Aβ), da fosforilação da tau e da Acetilcolinesterase (AChE), promovendo melhora dos déficits cognitivos e danos cerebrais. Considerações finais: Esta revisão evidenciou que ainda não há tratamento clínico eficaz para esta condição e nenhuma maneira de impedir a morte das células cerebrais. Todavia, percebe-se que flavonoides da D. gardneriana Tu. tem mostrado resultados promissores para o tratamento dos sintomas da DA.
Оценка роли Н. К. Михайловского в становлении революционного радикализма: историографический обзор
Authors: В.А. Исаков 
Published: October 2024

В статье представлен взгляд Н. К. Михайловского на радикальные методы политической борьбы: террор, организацию тайных обществ, роль меньшинства и народных масс в революционном процессе — в 1870–1880-е годы.
The article presents the view of N. K. Mikhailovsky’s radical methods of political struggle: terror, the organization of secret societies, the role of the minority and the masses in the revolutionary process — in the 1870–1880s.
Бронетехника ленд-лиза в битве за Москву, 1941–1942 годы
Authors: А.В. Хатанзейский 
Published: October 2024

Автор анализирует союзнические поставки бронетехники в СССР по программе ленд-лиза в контексте сражения за Москву в 1941‒1942 годах.
The author analyzes the allied deliveries of the armored vehicles to the USSR under the Lend-Lease program in the context of the battle for Moscow 1941–1942.
Историография изучения древнеегипетских глиняных сосудов с изображением бога Бэса
Authors: В.И. Ярмолович 
Published: October 2024

Статья посвящена историографии изучения древнеегипетских глиняных сосудов с изображением бога-карлика Бэса на их поверхности. В ней рассматриваются основные подходы, цели и задачи, связанные с исследованием этого вида сосудов, а также результаты, которые были достигнуты.
The article is devoted to the historiography of the study of ancient Egyptian vessels with the image of the dwarf god Bes on their surface. The article considers the main approaches to the study of this category of vessels, the goals and objectives associated with their study, as well as the results that have been achieved.
Октавиан в октябре 44 г. до н. э.: набор войск privato consilio
Authors: Ф.А. Михайловский 
Published: October 2024

Статья посвящена событиям осени 44 г. до н. э., которые император Август рассматривал как начало своей политической карьеры, когда он по собственной инициативе и на частные средства (privato consilio et privata impensa) набрал войско и вступил в борьбу с консулом М. Антонием. Автор выясняет ближайшие причины этой известной авантюры.
The article is devoted to the events of the fall of 44 B.C., which the emperor Augustus saw as the beginning of his political career, when he, on his own initiative and with private funds (privato consilio et privata impensa), recruited an army and entered into battle with consul M. Anthony. The author finds out the immediate causes of this famous adventure.
Национальное развитие Финляндии в составе Российской империи в 1905‒1917 годах: от модернизации к краху 1917 года
Authors: С.А. Агуреев 
Published: October 2024

Статья посвящена национально-политическому развитию Финляндии в составе Российской империи в 1905‒1917 годах. Автор прослеживает, как формировались национальные противоречия и развивалось революционное движение в Финляндии в этот период.
The article is devoted to the national-political development of Finland as part of the Russian Empire in the years 1905–1717. The author traces how national contradictions were formed, and the revolutionary movement in Finland developed during this period.
Патриотизм: проблемы дня
Authors: Е.И. Хаванов 
Published: October 2024

Статья посвящена содержанию понятия «патриотизм» в политической жизни современной России. Автор считает условием сохранения страны недопустимость раскола патриотических сил.
The article is devoted to the content of the concept of patriotism in the political life of modern Russia. The author considers the condition of preserving the country the inadmissibility of a split of patriotic forces.