bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caught between norm and difference: narratives on refugees’ inclusion in organizations
Authors: Ponzoni Elena , Ghorashi Halleh , van der Raad Sylvia 
Published: April 2017

PurposeIn this study the authors show how discursive spaces both enable and constrain the inclusion of first-generation refugees. For this purpose the authors analyzed a triptych of narratives from first-generation refugees, employers, and mediators (mediating between organizations and job-seeking refugees). The authors adopted a critical studies approach, paying particular attention to the ways in which meanings are embedded within the normalizing discursive processes. The purpose of this paper is to show the maneuvering capacities of three different groups concerning the inclusion of first-generation refugees.Design/methodology/approachThe data consist of a selected number of narratives from three groups of actors (refugees, mediators and employers) with the ambition of contrasting their discursive positionings. By including multiple positionings in the process, the authors aimed to reveal “the power effects of particular discursive formations,” which Alvessonet al.(2008) refer to as “positioning practices.” To investigate these patterns, the authors used in-depth interviews and employed an interpretive approach with the focus on the narrations of inclusion and exclusion.FindingsThe major constraint the authors discovered was that, in spite of the “good will” of all parties involved, the normalizing impact of the dominant discourses on migrants and refugees (discourse of lack) often works against other approaches (added value). This creates contradictory expectations toward refugees, limiting the possibilities of inclusion within organizations. The findings of this research show that diversity and inclusion can only be successful in conjunction with critical reflection that questions the taken-for-granted position of privileged groups as a norm reproduced by dominant societal discourses.Research limitations/implicationsIn the light of growing urgency for the inclusion of refugees in the European context, it is crucial to rethink the notions of inclusion and exclusion from a critical perspective. The authors believe that the findings of the study could have implications which goes beyond the particular experiences presented in this study.Originality/valueThe authors conclude that diversity talk and practice which does not include reflection on the normalizing power of discourses of otherness does not have a chance of making a long-term impact on inclusion. Although there is a growing body of literature on this topic within critical organization studies, there has been no attention so far for the position of refugees in organizations which makes this paper both unique and urgent.
The European virtual seminar on sustainable development as an opportunity for staff ESD competence development within university curricula
Authors: de Kraker Joop , Dlouhá Jana , Machackova Henderson Laura , Kapitulcinová Dana 
Published: April 2017

Purpose
The purpose of this paper is to assess the current and potential value of the European Virtual Seminar on Sustainable Development (EVS) as an opportunity for professional development in Education for Sustainable Development (ESD) for teaching staff at university level.

Design/methodology/approach
The paper presents and reflects on the specific case of EVS, including its competence-based approach and educational staff roles. Particular attention is paid to the development of ESD competences of tutors through participation in EVS, based on the UNECE (2011) competence framework and supported by the results from a small-scale questionnaire. Three major aspects of EVS as a professional opportunity in ESD are elaborated: EVS as an on-the-job training opportunity, EVS as an international staff mobility opportunity and EVS as an active learning and innovation community.

Findings
EVS is an effective opportunity for developing a range of ESD competences, especially for junior university staff. The contribution of EVS to professional development in ESD currently extends to a partnership of ten universities from across Europe, but given its features, the EVS approach has the potential to be adopted at a much larger scale. Possible limitations in scaling up are rigid rules for integration of new courses in curricula and the need to form new EVS-like partnerships.

Practical implications
This case study of EVS shows that Web-based, internationally networked courses with a pedagogical approach and design focused on ESD have a large potential in providing effective opportunities for the development of teachers’ ESD competences, but to realize this potential, active uptake of the approach by the existing networks for ESD in higher education is needed.

Originality/value
The paper presents a promising option to address the observed lack of opportunities within university curricula to acquire and practice ESD competences for teaching staff.
The health of older adults in community activities
Authors: Millard Jack 
Published: April 2017

Purpose
The purpose of this paper is to establish whether the inclusion of physical activity (PA) in a community programme setting is more beneficial than the benefit obtained from social participation for older adults.

Design/methodology/approach
A cross-sectional study conducted with a sample of 105 adults age 65+ and older that take part in community activities organised by the Bristol based charity LinkAge. Participants took part in either solely social groups or social groups with a PA component. A self-report questionnaire was composed of measures assessing functional health and well-being, health-related quality of life, functional ability, outcome expectation for exercise, and social support.

Findings
A significantly different and higher score on physical health measures was reported by the physically active group for role physical, physical function, bodily pain, and the physical capacity score. No significant difference was found for health measures that include a mental component. The physically active group reported higher outcome expectations for exercise.

Research limitations/implications
Social activity in community programmes may provide a method to maintain a healthy mental state in older adults, but participation in PA in the same environment is associated with better scores for physical health measures.

Originality/value
Providing greater support for older people to engage in physical and social activities may enable them to maintain a higher quality of life.
Lessons learned from designing and evaluating an educational brain fitness program
Authors: Nicholson Roscoe , O’Brien Catherine 
Published: April 2017

Purpose
The purpose of this paper is to provide aging services professional insights into older adult responses to brain fitness programs that may not appear on quantitative program evaluations.

Design/methodology/approach
Qualitative data obtained via observations, instructor interviews and feedback, open-ended responses on course evaluations and participant focus groups.

Findings
Participants come to brain fitness programs with a variety of expectations and preferences about program content. Some are looking for educational content, some wanted to learn memory strategies, and others are looking for drilling or brain games. Participants responded very positively to descriptions of brain fitness research and scientific details. However, presenting such content posed a challenge to non-expert instructors, and efforts should be made to reduce this burden. Instructors can play a valuable role in goal setting, but instructors and participants felt that small rewards for meeting goals were unnecessary. Both instructors and participants felt that peer-to-peer interaction is a particularly valuable component of such courses. Overburdening participants should also be avoided. Organizations offering the program were also found to be adapting the course to better fit the organization’s capacities and the desires of participants.

Research limitations/implications
The participant population is largely Caucasian, well-educated and middle to high socioeconomic status.

Practical implications
Due to the characteristics of the participant population, it is not known which, if any, of the findings apply to a less well-educated, lower income populations, or populations from other racial/ethnic groups.

Originality/value
These insights can assist senior living professionals in successfully creating, adopting or adapting brain fitness programs in order to best meet the needs of the populations that they serve.
Assessing Impact Direction in 3‐point Bending of Human Femora: Incomplete Butterfly Fractures and Fracture Surfaces,,
Authors: Isa Mariyam I. , Fenton Todd W. , Deland Trevor , Haut Roger C. 
Published: April 2017

AbstractCurrent literature associates bending failure with butterfly fracture, in which fracture initiates transversely at the tensile surface of a bent bone and branches as it propagates toward the impact surface. The orientation of the resulting wedge fragment is often considered diagnostic of impact direction. However, experimental studies indicate bending does not always produce complete butterfly fractures or produces wedge fragments variably in tension or compression, precluding their use in interpreting directionality. This study reports results of experimental 3‐point bending tests on thirteen unembalmed human femora. Complete fracture patterns varied following bending failure, but incomplete fractures and fracture surface characteristics were observed in all impacted specimens. A flat, billowy fracture surface was observed in tension, while jagged, angular peaks were observed in compression. Impact direction was accurately reconstructed using incomplete tension wedge butterfly fractures and tension and compression fracture surface criteria in all thirteen specimens.
Paediatric acute care: Highlights from the Paediatric Acute Care–Advanced Paediatric Life Support Conference, Adelaide, 2016
Authors: Teo Stephen SS , Schutz Jacquie , Stanford Jane , Rao Arjun 
Published: April 2017

AbstractThe Paediatric Acute Care Conference (PACC) is an annual conference organised by Advanced Paediatric Life Support Australia to advance paediatric acute care topics for clinicians in pre‐hospital medicine, EDs, acute paediatrics, intensive care and anaesthesia. The PACC 2016 was held at Glenelg, Adelaide, Australia. We provide a summary of some of the presentations.
Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study
Authors: Bao Wei , Dar Sharon , Zhu Yeyi , Wu Jing , Rawal Shristi , Li Shanshan , Weir Natalie L. , Tsai Michael Y. , Zhang Cuilin 
Published: April 2017

AbstractBackgroundAbnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. The aim of the present study was to characterize longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid concentrations with risk of GDM.MethodsThis study was a nested case‐control study including 107 GDM cases and 214 matched non‐GDM controls from participants in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies – Singleton cohort. Blood samples were collected longitudinally at Gestational Weeks (GW) 10–14, 15–26 (fasting sample), 23–31, and 33–39. Plasma concentrations of triglycerides, total cholesterol, and high‐density lipoprotein cholesterol (HDL‐C) were measured by enzymatic assays. Low‐density lipoprotein cholesterol (LDL‐C) was calculated using Friedewald's formula.ResultsPlasma triglycerides, total cholesterol, and LDL‐C increased as pregnancy progressed. At GW 10–14, the adjusted odds ratios (aORs) of GDM comparing the highest versus lowest quartile were 3.15 (95% confidence interval [CI] 1.38–7.15; P
trend = 0.002) for triglycerides and 0.44 (95% CI 0.18–1.09; P
trend = 0.045) for HDL‐C. At GW 15–26, the aORs were 6.57 (95% CI 2.25–19.17; P
trend = 0.001) for triglycerides and 0.23 (95% CI 0.08–0.63; P
trend = 0.005) for HDL‐C. No significant associations were observed for total cholesterol and LDL‐C concentrations with risk of GDM.ConclusionsHigher plasma triglyceride and lower HDL‐C concentrations in early and mid‐pregnancy were significantly associated with a greater risk of GDM. Total cholesterol and LDL‐C concentrations during pregnancy were not significantly associated with GDM risk.
Analyzing epidermal growth factor receptor mutation status changes in advanced non‐small‐cell lung cancer at different sampling time‐points of blood within one day
Authors: Wang Jin , Bai Hua , Hong Chaoyu , Wang Jie , Mei Tong‐hua 
Published: April 2017

BackgroundWe investigated whether different sampling time‐points within one day would influence epidermal growth factor receptor mutation (EGFRm) status in plasma and evaluated the clinical outcomes according to the quantity analysis of EGFRm in circulating tumor DNA (ctDNA) in non‐small‐cell lung cancer (NSCLC).Methods
EGFR‐tyrosine kinase inhibitor naïve advanced NSCLC patients who carried EGFRm in both tissues and ctDNA were enrolled in this study. Plasma samples were collected at three time‐points within one day (at 8 am, 11 am and 2 pm) for EGFRm analysis by droplet digital PCR.ResultsTwenty‐two advanced NSCLC patients were enrolled in the study. In a total of 66 blood specimens, the median EGFRm frequency was 7.13% (range 0–35.09%), and among them six specimens had less than 1.0% EGFRm frequency. Moreover, one time‐point blood specimen did not display any EGFRm, even by droplet digital PCR. The frequency of EGFRm changed dynamically across different time‐points within one day, but the differences were not significant (P = 0.557). We observed that patients with a relatively high frequency of EGFRm (>6.76%) had a better response to gefitinib (P = 0.024).ConclusionThe release of ctDNA maybe a temporal heterogenous process. The different sampling time‐points within one day did not seem to influence EGFRm status in ctDNA. The relative EGFRm frequency in ctDNA could predict a benefit of EGFR‐tyrosine kinase inhibitor treatment for advanced NSCLC patients.
Endoplasmic reticulum proteostasis impairment in aging
Authors: Martínez Gabriela , Duran‐Aniotz Claudia , Cabral‐Miranda Felipe , Vivar Juan P. , Hetz Claudio 
Published: April 2017

SummaryPerturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, folding, trafficking, secretion, and their degradation. A reduction in the buffering capacity of the proteostasis network during aging may increase the risk to undergo neurodegeneration by enhancing the accumulation of misfolded proteins. As almost one‐third of the proteome is synthetized at the endoplasmic reticulum (ER), maintenance of its proper function is fundamental to sustain neuronal function. In fact, ER stress is a common feature of most neurodegenerative diseases. The unfolded protein response (UPR) operates as central player to maintain ER homeostasis or the induction of cell death of chronically damaged cells. Here, we discuss recent evidence placing ER stress as a driver of brain aging, and the emerging impact of neuronal UPR in controlling global proteostasis at the whole organismal level. Finally, we discuss possible therapeutic interventions to improve proteostasis and prevent pathological brain aging.
A state‐price volatility index for the U.S. government bond market
Authors: Pan Zheyao 
Published: April 2017

AbstractUsing the Arrow–Debreu state‐contingent pricing methodology, this paper derives a U.S. government bond market volatility index (GBVX). I show that GBVX is an unbiased predictor for the next 30 day realised volatility of the Treasury note futures return. GBVX also subsumes the information of GARCH, EWMA and historical volatility measures. Furthermore, GBVX serves as an effective predictor for the future realised volatilities of a wide class of fixed income portfolios. The results suggest GBVX as a powerful instrument for volatility forecasting in the fixed income markets.
Selective imaging modalities after first pyelonephritis failed to identify significant urological anomalies, despite normal antenatal ultrasounds
Authors: Mola Gylli , Wenger Therese Ramstad , Salomonsson Petra , Knudsen Inge Jenny Dahl , Madsen Jan Lysgaard , Møller Søren , Olsen Beth Härstedt , Vinicoff Pablo Gustavo , Thorup Jorgen , Cortes Dina 
Published: April 2017

AbstractAimWe investigated the consequences of applying different imaging guidelines for urological anomalies after first pyelonephritis in children with normal routine antenatal ultrasounds.MethodsThe cohort comprised 472 children treated for their first culture‐positive pyelonephritis and investigated with ultrasound and renal scintigraphy. We excluded patients with known urological anomalies and patients born before routine antenatal ultrasound. We followed the cohort for a median of 5.7 years (3.1–10.1 years) by reviewing their medical reports.ResultsUrological anomalies were diagnosed in 95 patients. Dilated vesicoureteral reflux (VUR) was the predominant finding (n = 29), including nine who initially had surgery. Using imaging guidelines from the American Academy of Pediatrics would have missed 11 urological patients, including two with initial surgery, and avoided 339 scintigraphies. Using the European Association of Paediatric Urology guidance would have missed three urological patients, one with initial surgery, and avoided 46 scintigraphies. Investigating patients under two years with ultrasound and scintigraphy, and just ultrasound in children over two years, would have identified all patients initially treated with surgery and avoided 65 scintigraphies.ConclusionDilated VUR was the dominant anomaly in a cohort with first time pyelonephritis and normal antenatal ultrasound. The optimal imaging strategy after pyelonephritis must be identified.
Systematic review with meta‐analysis: the efficacy and safety of tenofovir to prevent mother‐to‐child transmission of hepatitis B virus
Authors: Hyun M. H. , Lee Y.‐S. , Kim J. H. , Je J. H. , Yoo Y. J. , Yeon J. E. , Byun K. S. 
Published: April 2017

SummaryBackgroundPreventing mother to child transmission of chronic hepatitis B infection in the setting of a high maternal viral load is challenging. The idea has emerged from antepartum tenofovir treatment with combination immunoprophylaxis.AimsTo demonstrate the efficacy and safety of tenofovir to prevent mother to child transmission of hepatitis B virus.MethodsPubMed, EMBASE, and Cochrane databases were searched through August 16, 2016. Comparative trials of second or third trimester tenofovir administration vs. controls for patients with chronic hepatitis B infection and non‐comparative case series assessing mother to child transmission rates and evaluating maternal and foetal safety outcomes were included.ResultsTen studies (one randomised controlled trial, four non‐randomised controlled trials and five case series) that enrolled 733 women were included. The pooled results from comparative trials (599 pregnancies) showed that tenofovir significantly reduced the risk of infant hepatitis B surface antigen seropositivity by 77% (odds ratio=0.23, 95% confidence intervals=0.10‐0.52, P=.0004) without heterogeneity (I2=0%). In the case series analysis (134 pregnancies), only two cases (1.5%) of mother to child transmission with extremely high maternal viral load and non‐compliance to treatment were identified. Maternal and foetal safety parameters including congenital malformation and foetal death were re‐assuring.ConclusionsFor pregnant women with high hepatitis B virus DNA levels, tenofovir administration in the second or third trimester can prevent mother to child transmission when combined with hepatitis B immunoglobulin and the hepatitis B vaccine. Tenofovir is safe and tolerable for both the mother and foetus.
Bilateral inguinal hernia after axillary‐femoral artery bypass effectively treated with laparoscopic repair: A case report
Authors: Susumu Seiya , Nagakawa Kantoku , Kawakami Shunsuke , Okada Kazuya , Kishikawa Hiroki 
Published: April 2017

AbstractWe report herein our experience with bilateral inguinal hernia surgery for a patient who had previously undergone a Y‐shaped vascular graft for an abdominal aortic aneurysm and then right axillary‐bilateral femoral artery bypass surgery. Preoperative physical examination and imaging revealed a subcutaneous vascular graft passing from the right axilla through the right flank region and branching at the lower abdomen to reach the femoral areas on both sides. As repair surgery by inguinal incision was considered difficult, we performed laparoscopic surgery. Bilateral direct hernia was observed on intraperitoneal observation. Essentially no intraperitoneal organ adhesion to the abdominal wall was present, and the previous surgery was also confirmed not to have reached the inguinal preperitoneal space. Transabdominal preperitoneal repair was therefore performed, yielding favorable results.
Inferring Network Structure in Non-normal and Mixed Discrete-continuous Genomic Data
Authors: Bhadra Anindya , Rao Arvind , Baladandayuthapani Veerabhadran 
Published: April 2017

Summary
Inferring dependence structure through undirected graphs is crucial for uncovering the major modes of multivariate interaction among high-dimensional genomic markers that are potentially associated with cancer. Traditionally, conditional independence has been studied using sparse Gaussian graphical models for continuous data and sparse Ising models for discrete data. However, there are two clear situations when these approaches are inadequate. The first occurs when the data are continuous but display non-normal marginal behavior such as heavy tails or skewness, rendering an assumption of normality inappropriate. The second occurs when a part of the data is ordinal or discrete (e.g., presence or absence of a mutation) and the other part is continuous (e.g., expression levels of genes or proteins). In this case, the existing Bayesian approaches typically employ a latent variable framework for the discrete part that precludes inferring conditional independence among the data that are actually observed. The current article overcomes these two challenges in a unified framework using Gaussian scale mixtures. Our framework is able to handle continuous data that are not normal and data that are of mixed continuous and discrete nature, while still being able to infer a sparse conditional sign independence structure among the observed data. Extensive performance comparison in simulations with alternative techniques and an analysis of a real cancer genomics data set demonstrate the effectiveness of the proposed approach.