bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensemble probability distribution of annual runoff for the past 70 years in two main watersheds of China
Authors: Song Fan , Wang Guangsheng , Yang Jianqing , Zhang Min , Ning Shaowei , Li Huimin , Xu Xiaoyan , Cheng Yang , Tan Yaogeng 
Published: October 2024

ABSTRACT

Water resources in China, especially in the major basins of the Songhua and Yangtze rivers, are characterized by uneven distribution both temporally and spatially, leading to notable challenges in per capita water availability. In this study, we investigate the ensemble probability distribution of annual runoff over the past 70 years in two of China's major watersheds: the Songhua River and the Yangtze River. By dividing each basin into several regions from upstream to downstream, based on annual mean discharge as a proxy for annual runoff, we observed a significant correlation between the annual runoff of the control sections and those of the upstream and downstream regions in these large watersheds. Consequently, this study establishes the probability distribution of annual runoff for each region within the basins, anchored on the design annual runoff of the control sections, using the joint bivariate logarithmic normal distribution of two interrelated random variables. Furthermore, we developed a relationship between the conditional probability distribution and correlation diagram data, and a regression equation correlating regional annual runoff with the watershed control section's runoff. This investigation into the historical patterns of runoff over the past 70 years provides a comprehensive understanding of the dynamics in these critical watersheds.
Correlations between Cerebrospinal Fluid Biomarkers and Gray Matter Atrophy in Alzheimer's and Behavioural Variant Frontotemporal Dementia
Authors: Scianatico Gaetano , Manippa Valerio , Zaca Domenico , Jovicich Jorge , Tafuri Benedetta , Rivolta Davide , Logroscino Giancarlo 
Published: October 2024

Introduction:
Distinguishing between frontotemporal dementia (FTD) and Alzheimer’s
disease (AD) in their early stages remains a significant clinical challenge. Cerebrospinal fluid (CSF)
biomarkers (total Tau, phosphorylated Tau, and beta-amyloid) are promising candidates for
identifying early differences between these conditions. This study investigates the relationship between
grey matter density and CSF markers in the behavioural variant of frontotemporal dementia
(bvFTD) and Alzheimer’s disease (AD).

Method:
CSF and 3D T1-weighted magnetic resonance (MR) images were acquired from 14
bvFTD patients, 15 AD patients, and 13 cognitively normal (CN) matched subjects. The CSF
markers and their relative ratios (total Tau/beta-amyloid, phosphorylated Tau/beta-amyloid) were
compared across the three groups. Voxel-based morphometry (VBM) was performed to characterize
the anatomical changes in bvFTD and AD patients compared to CN subjects. Grey matter density
maps were obtained by automatic segmentation of 3.0 Tesla 3D T1-Weighted MR Images,
and their correlation with CSF markers and relative ratios was investigated.

Results:
Results demonstrated that, as compared to CN subjects, AD patients are characterised by
higher CSF total Tau levels and lower beta-amyloid levels; however, beta-amyloid and relative ratios
discriminated AD from bvFTD. In addition, AD and bvFTD patients showed different patterns
of atrophy, with AD exhibiting more central (temporal areas) and bvFTD more anterior (frontal
areas) atrophy. A correlation was found between grey matter density maps and CSF marker
concentrations in the AD group, with total Tau and phosphorylated Tau levels showing a high association
with low grey matter density in the left superior temporal gyrus.

Conclusion:
Overall, while bvFTD lacks a CSF marker profile, CSF beta-amyloid levels are useful
for differentiating AD from bvFTD. Furthermore, MR structural imaging can contribute significantly
to distinguishing between the two pathologies.
Eco-friendly Synthesis of Gold Nanoparticles of Methanolic Extract of Bauhinia vahlii Leaves and Evaluation of Tyrosinase Inhibitory Activity
Authors: Panda Pritipadma , Pal Abhisek , Dash Priyanka , Kar Biswakanth , Rath Goutam , Ghosh Goutam 
Published: October 2024

Background:
The green synthesis of gold nanoparticles (AuNPs) using natural materials has
gained significant attention in recent years due to their eco-friendliness and potential applications in
various fields.

Methods:
The present study aimed at the green synthesis and anti-hyperpigmentation potential of gold
nanoparticles (AuNPs) using a methanolic extract of Bauhinia vahlii. Furthermore, the green synthesis
of the AuNPs was confirmed by UV-visible, FT-IR, XRD, and EMDEX analysis. The size and surface
topological significance of green synthesized AuNPs were evaluated through Scanning Electron Microscope
and Field Emission Scanning Electron Microscopy.

Results:
The size of the synthesized AuNPs was found to be in the range of 100-1000 nm. The tyrosinase
inhibitory activity of AuNPs was evaluated through the mushroom tyrosinase inhibitory assay
method. The tyrosinase inhibitory activities of crude extract, AuNPs, and Kojic acid were found to be
98.7 ±0.7, 75±1.3 and 41±1.1 μg/ml, respectively.

Conclusion:
Hence, green synthesized AuNPs of B. vahlii leaf extract may be used as a potent antihyperpigmentation
agent in the market of nano cosmeceuticals.
Current Insights into Therapeutic Potential of Terpenoids as Anticancer Agents
Authors: Sahoo Biswa Mohan , Banik Bimal Krishna , Sharma Shikha , Singh Bhupendra 
Published: October 2024

Background:
Cancer is regarded as one of the main causes of death globally. Future predictions indicate
that the death rate from cancer will keep rising, which may reach 11.4 million in 2030. Carcinogenesis refers
to the phenomenon of transforming a normal cell into a cancer cell. Cancer is characterized by unregulated and
uncontrolled cell division due to alterations at the molecular and genetic levels. Gene mutations can speed up the
rate of cell division, which leads to cancer. Metastasis entails the dissemination of cancer cells from the primary
site to distant regions of the body via the circulatory or lymphatic systems.

Objective:
This review is mainly focusing on the anticancer properties of terpenoids. In the case of human beings,
several types of cancers can be treated clinically based on the form and phase of the cancer. So, there are different
types of treatment regimens available for the management of cancer, such as immunotherapy, hormonal therapy,
radiation therapy, and chemotherapy.

Methods:
Several problems are associated with cancer therapy, including chemoresistance, severe toxicity, relapse,
and metastasis. To minimize these complications, natural products like terpenoids seem to be beneficial for
the effective management of cancer.

Results:
Experimental results revealed that the anticancer potential of terpenoids is due to activation of apoptosis
and stimulation of cell cycle arrest. Some of the terpenoids exhibit anticancer effects by inhibiting angiogenesis
and metastasis via the regulation of several signaling pathways intracellularly. Certain terpenoids have been
shown to work in concert with anticancer medications (doxorubicin, cisplatin, paclitaxel, and 5-fluorouracil) to
provide synergistic effects. These terpenoids have also been shown to be effective against cancer cells that are
resistant to several drug therapies.

Conclusion:
The current study will focus on signaling pathways and mode of action of several types of terpenoids
as anticancer agents. Further, it will provide insights into the ongoing clinical trials and prospective pathways
for the advancement of terpenoids as possible anti-cancer agents.
Studying the Antioxidant and Antimicrobial Activity of Lipsticks Made with Phycoerythrin Under the Influence of Different Magnetic Fields
Authors: Nowruzi Bahareh , Talapour Mohammadtaha 
Published: October 2024

Background:
Several studies have shown the benefits of magnetic treatment on the
productivity of secondary metabolites, growth, and the state of microalgae cultures

Objective:
This study examined the antioxidant and antimicrobial activity of lipsticks made with
phycoerythrin (PE) extracted from the cyanobacterium Nostoc sp. under the influence of different
magnetic fields (30 mT and 60 mT).

Material and Methods:
After cyanobacterial culture under magnetic fields of 30 mT and 60 mT,
the PE was extracted and lipsticks were formulated. The primary evaluation methods used in this
study are melting point, breaking point, linoleic acid peroxidation assay, force of application,
stability, surface abnormalities, skin irritation, thixotropy character, dispersibility test, perfume
stability, colorimetric assay, antioxidant, and microbial analysis

Results:
The 30 mT treatment showed the highest concentration, purity, dry weight, antioxidant
activity, and percentage of PE extraction compared to control cultures. No significant differences
were found in the melting point, stability, thixotropy character, dispersibility, or perfume stability
tests. The breaking point and force of application decreased significantly during 30 days. Peroxidation
assay tests revealed lipstick increased oxidation and antioxidant activity after 30 days of
30 and 60 mT treatments compared to non-PE cultures. The study found that the amount of ΔE
increased significantly in cultures without PE over time, while this increase was lower in magnetic
field-treated cultures. However, no signs of crystal formation, surface wrinkles, liquid secretion,
itching, or skin irritation were observed in 30 days of 30 and 60 mT magnetic treatments
compared to control cultures with PE. Microbial analyzes over 30 days showed a significantly
lower number of bacteria under magnetic fields than control cultures. In addition, the results of
counting Escherichia coli and coliform bacteria were negative for thirty days. The antioxidant
activity of PE was significantly higher in magnetic field-treated cultures. The number of Staphylococcus
aureus decreased significantly in all cultures under magnetic field influence.

Conclusions:
The overall results of this study showed that magnetic fields had a significant effect
in many evaluation tests on the culture of cyanobacteria Nostoc sp. As a result, lipsticks made
with extracted PE have more antioxidant and antimicrobial activity
Investigating the Acceptability of an Interactive Television Intervention Promoting Social Links Among Older Adults Living at Home and in Care Institutions: Qualitative Interview and Questionnaire Study
Authors: Naudé Bérangère , Rigaud Anne-Sophie , Pino Maribel 
Published: October 2024

Background
When older adults (OAs) can no longer live independently at home, they have the option to choose from various types of geriatric care institutions, such as residential facilities or nursing homes. For several years now, thanks to the development of interactive television (iTV), social link functions have been accessible directly on televisions, tools that are already integrated into residents’ rooms. The acceptance of technologies specifically targeting older users, as well as iTV, has been widely documented in the literature, incorporating factors from the innovation resistance model.

Objective
This research aims to enrich the acceptance of existing models of innovation by OAs living in different settings.

Methods
User tests were carried out to evaluate OAs’ experiences with iTV and identify the factors involved in its acceptance. A total of 32 OAs living at home, in nursing homes, or in residential facilities in France were interviewed between November 2022 and June 2023. iTV acceptance was examined using an interview grid based on the technology acceptance model and included the following factors: intention to use, perceived usefulness, perceived ease of use, user resistance, anxiety, facilitating conditions, and user characteristics.

Results
The deductive qualitative analysis based on the technology acceptance model helped to identify 33 concepts.

Conclusions
This study has contributed to the literature on the acceptance of iTV by OAs living at home and in geriatric institutions, particularly by enriching existing models and proposing new avenues for reflection.
Exploring Health Care Professionals’ Perspectives on the Use of a Medication and Care Support System and Recommendations for Designing a Similar Tool for Family Caregivers: Interview Study Among Health Care Professionals
Authors: Ashimwe Aimerence , Davoody Nadia 
Published: October 2024

Background
With the aging population on the rise, the demand for effective health care solutions to address adverse drug events is becoming increasingly urgent. Telemedicine has emerged as a promising solution for strengthening health care delivery in home care settings and mitigating drug errors. Due to the indispensable role of family caregivers in daily patient care, integrating digital health tools has the potential to streamline medication management processes and enhance the overall quality of patient care.

Objective
This study aims to explore health care professionals’ perspectives on the use of a medication and care support system (MCSS) and collect recommendations for designing a similar tool for family caregivers.

Methods
Fifteen interviews with health care professionals in a home care center were conducted. Thematic analysis was used, and 5 key themes highlighting the importance of using the MCSS tool to improve medication management in home care were identified.

Results
All participants emphasized the necessity of direct communication between health care professionals and family caregivers and stated that family caregivers need comprehensive information about medication administration, patient conditions, and symptoms. Furthermore, the health care professionals recommended features and functions customized for family caregivers.

Conclusions
This study underscored the importance of clear communication between health care professionals and family caregivers and the provision of comprehensive instructions to promote safe medication practices. By equipping family caregivers with essential information via a tool similar to the MCSS, a proactive approach to preventing errors and improving outcomes is advocated.
Correlación entre un WebECOE formativo y el rendimiento académico en estudiantes de medicina
Authors: Barboza Soria Saúl Alejandro , García Rivera Rocío Carolina , Trejo Mejía Juan Andrés , Martínez-González Adrián 
Published: October 2024

Introducción: El examen clínico objetivo estructurado (ECOE) es el estándar de oro para la evaluación de la competencia clínica. Derivado de la pandemia causada por el SARS-CoV-2, aumentó la necesidad de un instrumento para evaluarla a distancia.
Objetivo: Correlacionar la competencia clínica evaluada con un WebECOE formativo, con el rendimiento académico de estudiantes que finalizan el segundo año de la licenciatura de medicina.
Método: Se realizó un estudio observacional, correlacional. La prueba se le aplicó a la población que finalizó el segundo año de la licenciatura de medicina. El muestreo fue censal, y se desarrolló un WebECOE de 8 estaciones con una escala global de evaluación que contempla cuatro niveles de desempeño. Se realizaron análisis psicométricos y se correlacionó el nivel de competencia clínica del WebECOE con el rendimiento académico mediante la rho de Spearman. La retroalimentación se realizó con un programa automatizado posterior a la prueba.
Resultados: 207 estudiantes cumplieron con los criterios de inclusión del estudio para el análisis. La media del puntaje del WebECOE fue de 74.5, con los siguientes resultados por atributo: interrogatorio (70.7), exploración física (74.4), interpretación de estudios de gabinete (54.2), diagnóstico (67.9), manejo (83.0), profesionalismo y comunicación (84.5), trabajo en equipo (81.2), e integración clínica (67.6). El alfa de Cronbach fue de 0.89. La rho de Spearman para la correlación del rendimiento académico con el puntaje del WebECOE fue de 0.25 (p < 0.001).
Conclusión: El WebECOE es un instrumento con suficientes evidencias de validez para evaluar dimensiones de la competencia clínica a distancia, y esta tiene una correlación positiva con el rendimiento académico de los estudiantes.
Executive functioning in adults with attention deficit hyperactivity disorder: A systematic review
Authors: Rincón Carlos Francisco , Bernal Morales Lady , Tello Sandoval Sheylla 
Published: October 2024

Introduction: Executive function deficits are associated with attention deficit hyperactivity disorder (ADHD) in both children and adults. The inattentive subtype is primary related to “cold” executive functions, while the hyperactive subtype is related to “warm” executive functions.
Objective: To systematically review studies on executive functioning in adults with attention deficit hyperactivity disorder published during the last decade.
Methodology: A documentary research was conducted, encompassing 33 articles retrieved from PubMed, Web of Science and EBSCO platforms. The analysis considered years and countries of publication, attention deficit hyperactivity disorder diagnostic criteria, participants, comorbidities, subtypes, medication use, assessment tools, and processes of executive functions evaluated.
Results: It was evidenced that there is a high percentage of adults with attention deficit hyperactivity disorder who present a deficit or lower performance in executive function tests. However, the results varied depending on specific characteristics of the study and/or participants, which confirms the heterogeneity of the disorder. In addition, the main instruments for measuring executive functions and diagnostic criteria for adult attention deficit hyperactivity disorder were identified.
Discussion: These results support the established links between attention deficit hyperactivity disorder , impaired executive functions, and major life activities found in the adult attention deficit hyperactivity disorder literature. However, some of the limitations were the poorly controlled variables such as comorbidities, attention deficit hyperactivity disorder subtypes that were not assessed, and usage of instruments that measure executive functions that can lead to reduced credibility of the results presented here.
Conclusions: According to the results presented, there is a high percentage of adults with attention deficit hyperactivity disorder who present a deficit or lower performance in executive function tests, compared to both neurotypical adults and those with other psychiatric disorders. Further research is recommended to continue studies on the topic and to include other variables.
Efficacy of Fluorinated Nematicides for Management of Root-knot Nematodes in California Processing Tomatoes
Authors: Ploeg Antoon T. , Edwards Scott , Loffredo Angelo , Becker Jörn Ole 
Published: October 2024

Abstract
California is the primary US producer of processing tomatoes. After decades-long excellent protection against the common tropical Meloidogyne spp. M. incognita, M. javanica, and M. arenaria (root-knot nematode: RKN) by Mi-resistant tomato cultivars, resistance-breaking RKN populations are spreading throughout the San Joaquin Valley. For some time, nematicidal crop management tools have diminished under CA State regulatory pressure. In recent years, new non-volatile compounds have been developed with novel modes of action. In this project with susceptible processing tomato grown on an M. incognita-infested site, the efficacy of three fluorinated nematicides was evaluated in 10 field trials from 2011 to 2021. Seven trials included fluensulfone, six included fluazaindolizine, and five included fluopyram. On average, tomato root-galling (0 – 10 scale) at harvest was reduced by 3.2, 2.3, and 2.5 by fluazaindolizine, fluensulfone, and fluopyram, respectively, compared to the untreated control. These reductions in root-galling corresponded with estimated yield gains of approximately 21%, 14%, and 15%, respectively, over the untreated control. The reproduction of RKN during the tomato crop was not affected by the nematicides. The tested compounds have a very low acute mammalian toxicity and are more target-specific than previous generations of nematicides. However, there is considerable concern about the persistence of synthetic per- and polyfluoroalkyl substances (PFAS) in the environment, including pharmaceuticals and pesticides containing fluorine with the C-F3 functional group.
Antimicrobial Efficiency of Commercial Products for Drinking Water Based on Organic and/or Inorganic Acids Against Bacteria of Interest in Animal and Human Health
Authors: Specht Luana , Carvalho Daiane , Fangmeier Michele , Severo Luiza M. , Bayer Vitória F. , Leonhardt Fernanda , Retamal Fernando , Martins Abrahão Carvalho 
Published: October 2024

Objective: This study aims to evaluate the effects of acidity regulators based on organic and inorganic acids for drinking water on pathogens of importance in swine and poultry farming using the Minimum Inhibitory Concentration (MIC) test.

Theoretical Framework: The presence of intestinal pathogens in livestock production systems is a major global concern due to their impact on both animal and public health. Pathogens like Salmonella spp. and Escherichia coli are among the main microorganisms that adversely affect these systems, resulting in significant economic losses. Limitations on the use of antimicrobials, due to microbial resistance, require adopting alternative solutions for pathogen control.

Method: The statistical analysis of the MIC of acidity regulators against the microorganisms was performed using the Kruskal-Wallis test, followed by the Student-Newman-Keuls post-test (p<0.05) with GraphPad Prism software, version 8.0.1.

Results and Discussion: It was observed that the sensitization profile of the microorganisms differed depending on the species. Among the Salmonella serovars, there was a difference in the resistance profile between typhoidal and non-typhoidal Salmonella concerning the evaluated products. The results showed that among the commercially available acidifiers evaluated, only five were effective against all the microorganisms tested.