bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid pulmonary artery plication followed by transcatheter pulmonary valve replacement: Comparison with surgical PVR
Authors: Sosnowski Cyndi , Matella Thomas , Fogg Louis , Ilbawi Michel , Nagaraj Hosakote , Kavinsky Clifford , Wolf Andrew R , Diab Karim , Caputo Massimo , Kenny Damien 
Published: August 2016

Objective/BackgroundHistorically, the sole option for patients with a dysfunctional native right ventricular outflow tract (RVOT) requiring re‐establishment of pulmonary competence has been surgical PVR. We sought to compare early outcomes of hybrid pulmonary valve replacement (PVR) combining surgical plication of the main pulmonary artery followed by transcatheter PVR, with a contemporary cohort of surgical PVR patients.MethodsRetrospective chart analysis of all patients with a dilated native RVOT eligible for surgical PVR over 36 months was performed. The cohorts included patients with previous tetralogy of Fallot repair (n = 14), and previous intervention for congenital abnormality of the pulmonary valve (n = 7).ResultsTwenty‐one patients with a dysfunctional native RVOT met criteria for PVR; 8 using the hybrid procedure (group 1: age, 31.5 +/− 17.4 years) and 13 with cardiopulmonary bypass (CPB) (group 2: age, 31 +/− 18.4 years). Valve delivery was successful in all patients with no procedural mortality. Group 1 had a lesser requirement for blood products (P =< 0.001) and a trend toward shorter hospital stay and higher post‐operative hemoglobin. No patients in group 1 received inotropic support post‐operatively compared to 54% of patients in group 2. Mean follow‐up was 3.4 months for group 1 and 13.6 months for group 2 with the average peak gradient across the RVOT of 20.1 and 15.1 mm Hg respectively (P = 0.12), all with no more than mild PI.ConclusionsTranscatheter hybrid PVR following RVOT plication provides a reasonable alternative to surgical PVR particularly in higher risk cohorts, reducing possible longer‐term consequences of repeated runs of CPB. © 2016 Wiley Periodicals, Inc.
Conformational Preferences in Small Peptide Models: The Relevance of cis/trans‐Conformations
Authors: Jangra Harish , Haindl Michael H. , Achrainer Florian , Hioe Johnny , Gschwind Ruth M. , Zipse Hendrik 
Published: August 2016

AbstractThe accurate description of cis/trans peptide structures is of fundamental relevance for the field of protein modeling and protein structure determination. A comprehensive conformational analysis of dipeptide model Ace‐Gly‐NMe (1) has been carried out by using a combination of theoretical calculations and experimental (1H and 13C NMR and NOESY) spectroscopic measurements to assess the relevance of cis‐peptide conformers. NMR measurements in dimethyl sulfoxide (DMSO) solution and calculations employing a continuum solvation model both point to the extended trans,trans conformer C5_tt as the global minimum. The cis‐peptide structures C5_ct and C5_tc, with the N‐ or C‐terminal amide group in cis‐conformation, are observed separately and located 13.0±2 kJ mol−1 higher in energy. This is in close agreement with the theoretical prediction of around 12 kJ mol−1 in DMSO. The ability of common protein force fields to reproduce the energies of the cis‐amide conformers C5_ct and C5_tc in 1 is limited, making these methods unsuitable for the description of cis‐peptide structures in protein simulations.
Gold‐Catalyzed Cyclization of Furan‐Ynes bearing a Propargyl Carbonate Group: Intramolecular Diels–Alder Reaction with In Situ Generated Allenes
Authors: Sun Ning , Xie Xin , Chen Haoyi , Liu Yuanhong 
Published: August 2016

AbstractGold‐catalyzed cyclization of various furan‐ynes with a propargyl carbonate or ester moiety results in the formation of a series of polycyclic aromatic ring systems. The reactions can be rationalized through a tandem gold‐catalyzed 3,3‐rearrangement of the propargyl carboxylate moiety in furan‐yne substrates to form an allenic intermediate, which is followed by an intramolecular Diels–Alder reaction of furan and subsequent ring‐opening of the oxa‐bridged cycloadduct. It was found that the steric and electronic properties of phosphine ligands on the gold catalyst had a significant impact on the reaction outcome. In the case of 1,5‐furan‐yne, the cleavage of the oxa‐bridge in the cycloadduct with concomitant 1,2‐migration of the R1 group occurs to furnish anthracen‐1(2H)‐ones bearing a quaternary carbon center. For 1,4‐furan‐yne, a facile aromatization of the cycloadduct takes place to give 9‐oxygenated anthracene derivatives.
ChemInform Abstract: Li4Ge2B as a New Derivative of the Mo2B5 and Li5Sn2 Structure Types.
Authors: Pavlyuk Volodymyr , Ciesielski Wojciech , Rozdzynska‐Kielbik Beata , Dmytriv Grygoriy , Ehrenberg Helmut 
Published: August 2016

AbstractSingle crystals of Li4Ge2B are obtained by solid state reaction of stoichiometric mixtures of the elements (sealed Ta crucible, 1473 K, 15 min; rapid cooling to 25 °C).
ChemInform Abstract: Be2BO3F: A Phase of Beryllium Fluoride Borate Derived from KBe2BO3F2 with Short UV Absorption Edge.
Authors: Guo Shu , Liu Lijuan , Xia Mingjun , Kang Lei , Huang Qian , Li Chao , Wang Xiaoyang , Lin Zheshuai , Chen Chuangtian 
Published: August 2016

AbstractSingle crystals of Be2BO3F are grown by spontaneous nucleation from self‐fluxed high temperature solutions of NaBF4, BeO, B2O3, and LiF in the molar ratio of 1—1.5:1—2:0.5—1.5:1—3 (Pt crucible, 800 °C, 2 d).
ChemInform Abstract: Synthesis, Optical and Thermal Properties of Novel Tb3+ Doped RbCaF3 Fluoroperovskite Phosphors.
Authors: Raja A. , Annadurai G. , Daniel D. Joseph , Ramasamy P. 
Published: August 2016

AbstractPure and Tb‐doped RbCaF3 are prepared by sintering stoichiometric amounts of RbF, CaF2, and TbF3 (Al2O3 crucible, 850 °C, 12 h).
ChemInform Abstract: High‐Pressure Control of Vanadium Self‐Intercalation and Enhanced Metallic Properties in 1T‐V1+xS2 Single Crystals.
Authors: Moutaabbid Hicham , Le Godec Yann , Taverna Dario , Baptiste Benoit , Klein Yannick , Loupias Genevieve , Gauzzi Andrea 
Published: August 2016

AbstractHigh‐quality 1T‐V1+xS2 (x = 0.09—0.17) single crystals with self‐intercalated V atoms in the van der Waals gap of the layered host are prepared by first reacting a 1:2.1 molar mixture of V and S to achieve single crystalline V5S8 (750 °C, 3 weeks) followed by reaction with 2.05 equivs.
ChemInform Abstract: Cu Insertion into the Mo12 Cluster Compound Cs2Mo12Se14: Synthesis, Crystal and Electronic Structures, and Physical Properties.
Authors: Al Rahal Al Orabi Rabih , Fontaine Bruno , Gautier Regis , Gougeon Patrick , Gall Philippe , Bouyrie Yohan , Dauscher Anne , Candolfi Christophe , Lenoir Bertrand 
Published: August 2016

AbstractPolycrystalline Cs2CuxMo12Se14 (x = 0, 0.5, 1.0, 1.5, 2.0) phases are prepared by reacting stoichiometric amounts of Cs2Mo6Se8, Mo, and MoSe2 under Ar (sealed Mo crucible, 1573 K, 40 h) followed by reacting Cu powder with the as‐prepared material (evacuated silica tubes, 1173 K, 48 h).
ChemInform Abstract: A Highly Practical Approach to Chiral Homoallylic—Homopropargylic Amines via Aza‐Barbier Reaction.
Authors: Yuan Bin‐Hua , Zhang Zhi‐Cheng , Liu Wen‐Jie , Sun Xing‐Wen 
Published: August 2016

AbstractAza‐Barbier reactions of chiral ketimines and allyl bromides afford the title amines with high diastereoselectivity.
ChemInform Abstract: Lewis Base Catalyzed Trialkylsilylcyanide Additions to Cyclic 2‐Fluoroketones: Nucleophile Directed Access to Both cis‐ and trans‐Stereoisomers.
Authors: Brawley Kayla K. , Davis Todd A. 
Published: August 2016

AbstractCyclic 2‐fluoroketones react with cyanide (II) and iPr2NEt as the catalyst to give cis‐addition product predominantly, whereas methoxide catalyzed reactions with cyanide (V) favour the formation of trans‐addition products.
ChemInform Abstract: Stereoselective C(sp3)—C(sp2) Bond‐Forming Reactions by Transition‐Metal‐Free Reductive Coupling of Cyclic Tosylhydrazones with Boronic Acids.
Authors: Plaza Manuel , Perez‐Aguilar M. Carmen , Valdes Carlos 
Published: August 2016

AbstractA diastereoselective reductive alkenylation of tosylhydrazones derived from mono‐substituted cycloalkanones is achieved with alkenylboronic acids without the need for any metal catalyst.
ChemInform Abstract: Regioorientation in the Addition Reaction of α‐Substituted Cinnamonitrile to Enamines Utilizing Chitosan as a Green Catalyst: Unambiguous Structural Characterization Using 2D‐HMBC NMR Spectroscopy.
Authors: Ghozlan Said A. S. , Ahmed Ahmed Gamal , Abdelhamid Ismail Abdelshafy 
Published: August 2016

AbstractHexahydroquinolines and their fused derivatives are efficiently prepared in good to excellent yields.
ChemInform Abstract: Intermolecular Homopropargyl Alcohol Addition to Alkyne and a Sequential 1,6‐Enyne Cycloisomerization with Triazole‐Gold Catalyst.
Authors: Hosseyni Seyedmorteza , Wojtas Lukasz , Li Minyong , Shi Xiaodong 
Published: August 2016

AbstractUtilization of a benzotriazole‐based gold catalyst prevents the known intramolecular cyclization of homopropargylic alcohols (HPAs), allowing for the first intermolecular addition of alkynes to HPAs with subsequent intramolecular enyne cycloisomerization.
ChemInform Abstract: A Hydrazone‐Based exo‐Directing‐Group Strategy for β C—H Oxidation of Aliphatic Amines.
Authors: Huang Zhongxing , Wang Chengpeng , Dong Guangbin 
Published: August 2016

AbstractA new hydrazone‐based exo‐directing group (DG) strategy is developed for the functionalization of unactivated primary β C—H bonds of aliphatic amines.
ChemInform Abstract: KOtBu‐Initiated Aryl C—H Iodination: A Powerful Tool for the Synthesis of High Electron Affinity Compounds.
Authors: Shi Qinqin , Zhang Siyuan , Zhang Junxiang , Oswald Victoria F. , Amassian Aram , Marder Seth R. , Blakey Simon B. 
Published: August 2016

AbstractThis efficient protocol for iodination of electron‐deficient heterocycles is proposed to rely on a radical reaction initiated by single electron transfer from tBuOK to pentafluoroiodobenzene.
ChemInform Abstract: Direct Olefination of Alcohols with Sulfones by Using Heterogeneous Platinum Catalysts.
Authors: Siddiki S. M. A. Hakim , Touchy Abeda Sultana , Kon Kenichi , Shimizu Ken‐ichi 
Published: August 2016

AbstractCarbon‐supported Pt nanoparticles (Pt/C) are established as effective heterogeneous catalysts for the direct Julia olefination of alcohols in the presence of sulfones and KOtBu under oxidant‐free conditions.
ChemInform Abstract: One‐Pot Synthesis of Enantiomerically Pure N‐Protected Allylic Amines from N‐Protected α‐Amino Esters.
Authors: Silveira‐Dorta Gaston , Alvarez‐Mendez Sergio J , Martin Victor S , Padron Jose M 
Published: August 2016

AbstractEnantiomerically pure allylic amines are obtained by an improved one‐pot tandem reduction‐olefination process utilizing N‐protected α‐amino esters derived from natural amino acids.
ChemInform Abstract: 2,2,2‐Trifluoroethyl Oxalates in the One‐Pot Parallel Synthesis of Hindered Aliphatic Oxamides.
Authors: Moroz Yurii S. , et al.  
Published: August 2016

AbstractUnsymmetrical N1,N2‐substituted aliphatic oxamides (52 examples) are prepared by stepwise aminolysis of methyl(trifluoroethyl)oxalate or bis(trifluoroethyl)oxalate with hindered primary and secondary aliphatic amines, resp., in moderate yields.
ChemInform Abstract: Formamide Synthesis Through Borinic Acid Catalyzed Transamidation under Mild Conditions.
Authors: Dine Tharwat Mohy El , Evans David , Rouden Jacques , Blanchet Jerome 
Published: August 2016

AbstractAn efficient and mild transamidation of amides with amines co‐catalyzed by borinic acid and acetic acid is reported.
ChemInform Abstract: The Addition of Polyfluoroalkanesulfenic Acids to Alkenes.
Authors: Li Xiao‐Bo , Zhao Juan , Jiang Min , Liu Jin‐Tao 
Published: August 2016

AbstractIt is shown that the addition of in situ generated polyfluoroalkanesulfenic acids to non‐cyclic dienes regioselectively affords Markovnikov adducts, whereas Michael‐type adducts are obtained in the reaction of activated alkenes.
ChemInform Abstract: Halogenase‐Inspired Oxidative Chlorination Using Flavin Photocatalysis.
Authors: Hering Thea , Muehldorf Bernd , Wolf Robert , Koenig Burkhard 
Published: August 2016

AbstractThis photocatalytic oxidative chlorination is based on utilization of riboflavin tetraacetate which mimicks an enzymatic process.
ChemInform Abstract: Operationally Simple and Selective One‐Pot Synthesis of Hydroxyphenones: A Facile Access to SNARF Dyes.
Authors: Richter Celin , Ernsting Nikolaus P. , Mahrwald Rainer 
Published: August 2016

AbstractCompound (VIIb) is used as precursor in the synthesis of SNARF dye (XII).
ChemInform Abstract: Preparations of Saturated N‐P‐N Type Secondary Phosphine Oxides and Their Applications in Cross‐Coupling Reactions.
Authors: Chang Yu‐Chang , Liang Ya‐Han , Hong Fung‐E. 
Published: August 2016

AbstractMetastable saturated heteroatom‐substituted secondary phosphine oxides, tautomers of the saturated heteroatom‐substituted phosphinous acid, are prepared and utilized as ancillary ligand in Pd‐catalyzed Suzuki—Miyaura cross‐coupling reactions of bromoanisole with phenylboronic acid.
ChemInform Abstract: Eco‐Friendly Suzuki—Miyaura Coupling of Arylboronic Acids to Aromatic Ketones Catalyzed by the Oxime‐Palladacycle in Biosolvent 2‐MeTHF.
Authors: Mondal Manoj , Bora Utpal 
Published: August 2016

AbstractThe use of water unmixable 2‐MeTHF as solvent is an important advantage of the title method, because it provides the easy isolation of the crude reaction mixture just by separation of 2‐MeTHF‐water layers, followed by evaporation of 2‐MeTHF.
ChemInform Abstract: Stereoselective Synthesis of Tricyclic Compounds by Intramolecular Palladium‐Catalyzed Addition of Aryl Iodides to Carbonyl Groups.
Authors: Saadi Jakub , Bentz Christoph , Redies Kai , Lentz Dieter , Zimmer Reinhold , Reissig Hans‐Ulrich 
Published: August 2016

AbstractEducts (I) bearing a cyclopentanone moiety afford only low amounts of tricycles (II) and (III) (20%, detailed determination of the stereochemistry not possible).
ChemInform Abstract: Synthesis of Dinitrogen‐Fused Spirocyclic Heterocycles via Organocatalytic 1,3‐Dipolar Cycloaddition of 2‐Arylidene‐1,3‐indandiones and an Azomethine Imine.
Authors: Duan Jindian , Cheng Jing , Cheng Yuyu , Li Pengfei 
Published: August 2016

AbstractAn efficient Et3N‐catalyzed 1,3‐dipolar cycloaddition of the title indandiones with pyrazolidine‐based azomethine imines furnishes spiro[indane‐1,3‐dione‐pyrazolidinones] in generally good to high yields with excellent diastereoselectivity under mild conditions.
ChemInform Abstract: Catalytic Asymmetric Prins Bicyclization for the endo‐Selective Formation of 2,6‐Dioxabicyclo[2.2.2]octanes.
Authors: Liu Jie , Zhou Lijun , Wang Chao , Liang Demin , Li Zhiming , Zou Yue , Wang Quanrui , Goeke Andreas 
Published: August 2016

AbstractA novel FeCl3‐catalyzed bis‐Prins‐cyclization of homoallylic aldehydes (I) and (IV) and the related ketone (VI) with aliphatic and aromatic aldehydes (II) is developed to give 2,6‐dioxabicyclo[2.2.2]octanes in excellent endo‐diastereoselectivity.
ChemInform Abstract: Copper(I)‐Catalyzed Heterocyclization of α‐Acyl‐α‐alkynyl Ketene Dithioacetals: Synthesis of 3‐Cyanofurans.
Authors: Wang Lianjie , Liu Xiaocui , Wang Mang , Liu Jun 
Published: August 2016

AbstractThe heterocyclization procedure generates a cyano moiety in situ with ammonium acetate as the nitrogen source providing 3‐cyanofuran derivatives in good to excellent yield.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Dehydrogenative Coupling—Michael Addition: Direct Synthesis of Phthalides from Benzoic Acids and Alkenes.
Authors: Renzetti Andrea , Nakazawa Hiroshi , Li Chao‐Jun 
Published: August 2016

AbstractThis new method provides access to phthalides by reaction of benzoic acids with vinyl ethyl ketone, methyl acrylate, N,N‐dimethylacrylamide, ethyl and phenyl vinyl sulfones with interesting regio‐ and chemoselectivity though often in moderate yields only.
ChemInform Abstract: Pd(0)‐Catalyzed Dearomative Diarylation of Indoles.
Authors: Petrone David A. , Kondo Masaru , Zeidan Nicolas , Lautens Mark 
Published: August 2016

AbstractA fully syn‐selective Pd(0)‐catalyzed dearomative indole 1,2‐diarylation is presented by using PtBu3 as the ligand.
ChemInform Abstract: Pd(0)‐Catalyzed Direct C—H Functionalization of 2‐H‐4‐Benzylidene Imidazolones: Friendly and Large‐Scale Access to GFP and Kaede Protein Fluorophores.
Authors: Muselli Mickael , Baudequin Christine , Perrio Cecile , Hoarau Christophe , Bischoff Laurent 
Published: August 2016

AbstractPalladium‐catalyzed and copper‐assisted direct C2—H arylation and alkenylation of benzylidene imidazolones (available by a one‐pot synthesis) with aryl‐ and alkenylhalides is described.
ChemInform Abstract: A Convenient Synthesis of Bisbenzimidazoles from Iminoester Hydrochlorides via Microwave Technique.
Authors: Kahveci B. , Mentese E. , Oezil M. , Yilmaz F. , Serdar M. 
Published: August 2016

AbstractThe title compounds are prepared by cyclocondensation of diaminobenzidine with several iminoester hydrochlorides of phenylacetic acids in short times and high yields.
ChemInform Abstract: (Enantio)selective Hydrogen Autotransfer: Ruthenium‐Catalyzed Synthesis of Oxazolidin‐2‐ones from Urea and Diols.
Authors: Pena‐Lopez Miguel , Neumann Helfried , Beller Matthias 
Published: August 2016

AbstractTwo different C—O and C—N bonds are sequentially generated with high chemo‐ and regioselectivity by an environmentally benign domino process involving a nucleophilic substitution and alcohol amination.
ChemInform Abstract: Gold(I)‐Catalyzed Intramolecular Hydroarylation and the Subsequent Ring Enlargement of Methylenecyclopropanes to Cyclobutenes.
Authors: Fang Wei , Tang Xiang‐Ying , Shi Min 
Published: August 2016

AbstractThe intramolecular hydroarylation of methylenecyclopropanes containing aryl propargyl ethers gives 2H‐chromene derivatives under mild conditions.
ChemInform Abstract: Cobalt‐Catalyzed Cyclization of N‐Methoxy Benzamides with Alkynes Using an Internal Oxidant Through C—H/N—O Bond Activation.
Authors: Sivakumar Ganesan , Vijeta Arjun , Jeganmohan Masilamani 
Published: August 2016

AbstractThe cyclization of substituted N‐methoxy benzamides with alkynes in the presence of an readily available cobalt complex and NaOAc provides isoquinolone derivatives in good to excellent yields.
ChemInform Abstract: Facile Syntheses of Fluorine‐Containing 4‐Methoxypyrazolo[4,3‐c]quinolines and 6‐Methoxy‐1,4‐diazepino[6,5‐c]quinolines.
Authors: Okada Etsuji , Hatakenaka Mizuki , Adachi Satoru 
Published: August 2016

AbstractThe intramolecular cyclization of dimethylaminoquinoline (I) with various hydrazines is used for the preparation of the title compounds by a chemoselective N‐N exchange reaction.
ChemInform Abstract: Highly Selective Catalytic trans‐Hydroboration of Alkynes Mediated by Borenium Cations and B(C6F5)3.
Authors: McGough John S. , Butler Samuel M. , Cade Ian A. , Ingleson Michael J. 
Published: August 2016

AbstractUtilization of highly Lewis‐acidic boranes allows for transition metal‐free hydroboration of (hetero)aryl‐ and vinyl substituted terminal alkynes.
ChemInform Abstract: N‐Heterocyclic Carbene—Ytterbium Amide as a Recyclable Homogeneous Precatalyst for Hydrophosphination of Alkenes and Alkynes.
Authors: Yuan Jia , Hu Hongfan , Cui Chunming 
Published: August 2016

AbstractThree N‐heterocyclic carbene—ytterbium(II) amide complexes are synthesized and characterized.
ChemInform Abstract: Two New Triterpenoids from the Roots of Rhodomyrtus tomentosa.
Authors: Zhang Yu‐Bo , Li Wen , Zhang Ze‐Ming , Chen Neng‐Hua , Zhang Xiang‐Qiang , Jiang Jian‐Wei , Wang Guo‐Cai , Li Yao‐Lan 
Published: August 2016

AbstractTwo new triterpenoids, tomentoids A (Ia) and B (Ib), are isolated from the roots of Rhodomyrtus tomentosa together with five known triterpenoids.
ChemInform Abstract: Readily Accessible Bulky Iron Catalysts Exhibiting Site Selectivity in the Oxidation of Steroidal Substrates.
Authors: Font David , Canta Merce , Milan Michela , Cusso Olaf , Ribas Xavi , Klein Gebbink Robertus J. M. , Costas Miquel 
Published: August 2016

AbstractBulky iron complexes are able to catalyze the site‐selective oxidation of alkyl C—H bonds with hydrogen peroxide.
ChemInform Abstract: Flavonoid Glycosides from Siparuna gigantotepala Leaves and Their Antioxidant Activity.
Authors: Torres Castaneda Harlen Gerardo , Colmenares Dulcey Ana Julia , Isaza Martinez Jose Hipolito 
Published: August 2016

AbstractTwo new flavonol glycosides (I) and (II) are isolated from Siparuna gigantotepala leaves along with six known compounds.
ChemInform Abstract: Lasiolactols A and B Produced by the Grapevine Fungal Pathogen Lasiodiplodia mediterranea
Authors: Andolfi Anna , Basso Sara , Giambra Selene , Conigliaro Gaetano , Lo Piccolo Sandra , Alves Artur , Burruano Santella 
Published: August 2016

Abstractisolation and structure elucidation of lasiolactols A (I) and B (II)
ChemInform Abstract: All‐Carbon N‐Heterocyclic Carbene‐Catalyzed [3 + 2] Annulation Using Donor—Acceptor Cyclopropanes
Authors: Candish Lisa , Gillard Rachel M. , Fernando Jared E. M. , Levens Alison , Lupton David W. 
Published: August 2016

AbstractReview: [24 refs.
Rapid identification of Helicobacter pylori and assessment of clarithromycin susceptibility from clinical specimens using FISH
Authors: Demiray‐Gürbüz Ebru , Yılmaz Özlem , Olivares Asalia Z , Gönen Can , Sarıoğlu Sülen , Soytürk Müjde , Tümer Sait , Altungöz Oğuz , Şimşek İlkay , Perez Perez Guillermo I 
Published: August 2016

AbstractHelicobacter pylori remains one of the most common bacterial infections worldwide. Clarithromycin resistance is the most important cause of H. pylori eradication failures. Effective antibiotic therapies in H. pylori infection must be rapidly adapted to local resistance patterns. We investigated the prevalence of clarithromycin resistance due to mutations in positions 2142 and 2143 of 23SrRNA gene of H. pylori by fluorescence in situ hybridisation (FISH), and compared with culture and antimicrobial susceptibility testing in 234 adult patients with dyspepsia who were enrolled. Antrum and corpus biopsy specimens were obtained for rapid urease test, histopathology and culture. Epsilometer test was used to assess clarithromycin susceptibility. H. pylori presence and clarithromycin susceptibility were determined by FISH in paraffin‐embedded biopsy specimens. We found that 164 (70.1%) patients were positive for H. pylori based on clinical criteria, 114 (69.5% CI 62.5–76.6%) were culture positive, and 137 (83.5% CI 77.8–89.2%) were FISH positive. Thus the sensitivity of FISH was significantly superior to that of culture. However specificity was not significantly different (91.4 versus 100.0%, respectively). The resistance rate to clarithromycin for both antrum and corpus was detected in H. pylori‐positive patients; 20.2% by FISH and 28.0% by E‐test.The concordance between E‐test and FISH was only 89.5% due to the presence of point mutations different from A2143G, A2142G or A2142C. We conclude that FISH is significantly more sensitive than culture and the E‐test for the detection of H. pylori and for rapid determinination of claritromycin susceptibility. The superior hybridisation efficiency of FISH is becoming an emerging molecular tool as a reliable, rapid and sensitive method for the detection and visualisation of H. pylori, especially when the management of H. pylori eradication therapy is necessary. This is particularly important for the treatment of patients with H. pylori eradication failure.