bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer: The Kaiser Permanente AYA Cancer Survivors Study
Authors: Chao Chun , Xu Lanfang , Bhatia Smita , Cooper Robert , Brar Somjot , Wong F. Lennie , Armenian Saro H. 
Published: March 2016

Purpose To describe the epidemiology and risk factors for cardiovascular disease (CVD) in survivors of adolescent and young adult (AYA) cancer. Methods We identified a retrospective cohort of 2-year survivors of AYA cancer who were diagnosed between the ages of 15 to 39 years (1998 to 2009) at Kaiser Permanente Southern California. A comparison group without cancer was selected and matched 10:1 to cancer survivors on the basis of age, sex, Kaiser Permanente Southern California membership, and calendar year. Patients were followed through December 31, 2012, for coronary artery disease, heart failure, and stroke. Time-dependent Poisson regression was used to evaluate the effect that cancer survivorship had on the risk of developing CVD, adjusted for cardiovascular risk factors (CVRFs; ie, diabetes, hypertension, and dyslipidemia), ethnicity, smoking, and overweight/obesity. Among cancer survivors, mortality risk by CVD status was examined using Cox regression. Results A total of 5,673 2-year survivors of AYA cancer and 57,617 comparison patients were included, representing 24,839 and 239,073 person-years of follow-up, respectively. Overall, cancer survivors had more than two-fold risk of developing CVD (adjusted incidence rate ratio, 2.37; 95% CI, 1.93 to 2.93) when compared with patients without cancer; survivors of leukemia and breast cancer were at the highest risk (adjusted incidence rate ratio, 4.23; 95% CI, 1.73 to 10.31; and 3.63; 95% CI, 2.41 to 5.47, respectively) of developing CVD. Having any of the CVRFs increased the risk of CVD in cancer survivors. Cancer survivors who developed CVD had an 11-fold increased overall mortality risk (hazard ratio, 10.9; 95% CI, 8.1 to 14.8) when compared with survivors without CVD. Conclusion Survivors of AYA cancer are at increased risk for developing CVD. Survival after CVD onset is compromised, and CVRFs are independent modifiers of CVD risk. These data form the basis for identifying high-risk individuals and proactive management of CVRFs.
Case Report: Rectal perforation during CT colonography
Authors: Zukiwskyj Marianna , Arafat Yasser 
Published: March 2016

IntroductionComputer tomography colonoscopy (CTC) is an increasingly prevalent procedure for the investigation of colorectal symptoms, or as a component of colorectal cancer screening. It is considered a low risk procedure, however colonic perforation is a recognized significant complication.Case ReportWe report the case of an 81-year-old female patient who underwent CTC after failed optical colonoscopy as part of routine colorectal cancer screening. Perforation of the rectum with surrounding pararectal air was confirmed on CTC. The patient had minimal symptoms and was treated successful non-operatively with bowel rest and antibiotics.ConclusionPerforation sustained during CTC is an uncommon complication. The incidence of perforation during CTC is still lower than that during optical colonoscopy. In the absence of significant abdominal signs and symptoms, this rare complication may be successfully managed non-operatively.
How Do Delay Announcements Shape Customer Behavior? An Empirical Study
Authors: Yu Qiuping , Allon Gad , Bassamboo Achal 
Published: March 2016

In this paper, we explore the impact of delay announcements using an empirical approach by analyzing the data from a medium-sized call center. We first explore the question of whether delay announcements impact customers’ behavior using a nonparametric approach. The answer to this question appears to be ambiguous. We thus turn to investigate the fundamental mechanism by which delay announcements impact customer behavior, by constructing a dynamic structural model. In contrast to the implicit assumption made in the literature that announcements do not directly impact customers’ waiting costs, our key insights show that delay announcements not only impact customers’ beliefs about the system but also directly impact customers’ waiting costs. In particular, customers’ per-unit waiting cost decreases with the offered waiting times associated with the announcements. The results of our counterfactual analysis show that it may not be necessary to provide announcements with very fine granularity. This paper was accepted by Yossi Aviv, operations management.
Length-weight relationship and population genetic of two marine gastropods species (Turbinidae: Turbo sparverius and Turbo bruneus) in the Bird Seascape Papua, Indonesia
Authors: SALEKY DANDI , SETYOBUDIANDI ISDRAJAD , TOHA HAMID A. , TAKDIR MUHAMMAD , MADDUPPA HAWIS H. 
Published: March 2016

Length-weight relationship and population genetic of two marine gastropods species (Turbinidae: Turbo sparverius and Turbo bruneus) in the Bird Seascape Papua, Indonesia. Biodiversitas 17: 208-217. Turbo sparverius and Turbo bruneus are herbivorous grazers gastropod that lived on the rocky intertidal area, which have a role in maintaining algae on the intertidal ecosystem. Local people in Papua have exploited them for food and souvenirs. Even though this exploitation might affect their genetic diversity and population, a study of the genetic structure of these species has not been previously reported. This study aimed to analyze the morphometric, genetic diversity, population structure and connectivity of T. sparverius and T. bruneus in coastal water of West Papua, Indonesia. The results showed that the growth pattern of T. sparverius and T. bruneus in all populations were negative allometric, which means that weight gain was slower than length. Haplotype diversity value of all population T. sparverius and T. bruneus were 0.657-0.705 and 0.739-0.816, respectively. In addition, the haplotype diversity of eachÂ population showed a high level of diversity. The genetic structure was found in all population of T. sparverius and T. bruneus with F value-0.037-0.201 and 0.031, respectively. Population structure and phylogenetic tree showed the closeness of genetic due to gene flow between both T. sparverius and T. bruneus. Genetic distance value between populations T. sparverius and T. bruneus are very low were 0.002 and 0.003-0.004, respectively. High genetic similarity might occur due to condition and direction of current flow mediating ofÂ gene transport among population, and the similarity of habitats in each population.
Identifying risk in the use of tumor markers to improve patient safety
Authors: Moreno-Campoy Elvira Eva , Mérida-De la Torre Francisco J. , Martos-Crespo Francisco , Plebani Mario 
Published: March 2016

Abstract

Background:
Tumor markers (TM) are a routine test that are not always used well, and can lead to unnecessary additional tests, which are not without risks for the patients. So, to implement appropriate strategies to improve the adequate use of TM and, therefore, improve patient safety, is required to analyze the use of TM, identifying risks and establishing if there are differences in their use as a function of their utility.

Methods:
The study was a descriptive, longitudinal, retrospective and systematic study in the area covered by the University Hospital of Padua. In the follow-up 2-year study, 23,059 analytical requests of TM, corresponding to 14,728 patients, were analyzed. For the level of statistical significance it applies an approximation of the normal law (Z statistic) and χ2-test.

Results:
Only 9196 requests (39.88%) out of a total of 23,059 on 5080 patients with neoplastic diseases have been classified as adecuate according to current guidelines. The number of requests per patient was variable (1.57±1.35). In patients with neoplastic diseases this increased to 1.80±1.68. The mean of number of TM per request was 2.4±1.73. The analysis showed an association between the number of requests and the type of marker used.

Conclusions:
The use of TM is variable, mainly of the follow-up markers, when they are used as screening. This inappropriate use, minimizes their utility favoring erroneous interpretations and increases the risk of damage to the patient. So it is essential to implement safe practices in the use of TM.
Mathematical Modeling and Investigation on the Temperature and Pressure Dependency of Permeation and Membrane Separation Performance for Natural gas Treatment
Authors: Hosseini Seyed Saeid , Dehkordi Javad Aminian , Kundu Prodip K. 
Published: March 2016

Abstract
Due to special features, modules comprising asymmetric hollow fiber membranes are widely used in various industrial gas separation processes. Accordingly, numerous mathematical models have been proposed for predicting and analyzing the performance. However, majority of the proposed models for this purpose assume that membrane permeance remains constant upon changes in temperature and pressure. In this study, a mathematical model is proposed by taking into account non-ideal effects including changes in pressure and temperature in both sides of hollow fibers, concentration polarization and Joule-Thomson effects. Finite element method is employed to solve the governing equations and model is validated using experimental data. The effect of temperature and pressure dependency of permeance and separation performance of hollow fiber membrane modules is investigated in the case of CO2/CH4. The effect of temperature and pressure dependence of membrane permeance is studied by using type Arrhenius type and partial immobilization equations to understand which form of the equations fits experimental data best. Findings reveal that the prediction of membrane performance for CO2/CH4 separation is highly related to pressure and temperature; the models considering temperature and pressure dependence of membrane permeance match experimental data with higher accuracy. Also, results suggest that partial immobilization model represents a better prediction to the experimental data than Arrhenius type equation.
Multi-objective Optimization of Preparation Conditions of Asymmetric Polyetherimide Membrane for Prevaporation of Isopropanol
Authors: Nabavi Seyed Reza 
Published: March 2016

Abstract
Multi-objective optimization is used in many chemical engineering fields that have conflict objective functions. Prevaporation is an effective process for removing trace or minor amount of the component of diluting solutions. This process is used for dehydration of alcohols containing small amounts of water. In this process membrane flux and separation factor have conflict with each other. So a multi-objective optimization approach can be used for optimization of the process. In this paper, in first stage a neural network based model was developed for preparation conditions for polyetherimide membrane in isopropanol prevaporation. Four major variables involved in the membrane preparation procedure, including polymer concentration, additive content, solvent evaporation temperature and time was considered. Membrane flux and separation factor were considered as objective functions. Elitist Non-dominated sorting genetic algorithm with jumping gene and altruistic adaptation (Alt-NSGA-aJG) was applied for simultaneous maximization of flux and separation factor. Pareto optimal solutions for membrane preparation conditions and effect of decision variables (four preparation variables) on Pareto front were investigated.
Ultrasound guided joint space distance changes during manual traction of acromioclavicular joint in young and healthy adults
Authors: Marciniak Tomasz , Brożyński Maciej , Wit Andrzej 
Published: March 2016

Abstract
Introduction: Manual traction is a commonly used technique in manual therapy. However, depicting changes in joint space distance via real time imaging during traction is seldomly applied. The aims of the study were to identify ACJ joint space distance changes during manual traction and creation of a classification of the techniques upon the largest change in the resultant parameter (l) representing joint space distance.
Material and methods: Thirteen healthy volunteers were examined unilaterally. Acromioclavicular joint space distance changes were measured with dynamic ultrasound imaging during followingmanual traction techniques: International Academy of Orthopedic Medicine technique (IAOM AC), Karel Lewit’s Prague School of Manual Medicine & Rehabilitation technique (LAC) and author’s own proposition (B AC). The differences in joint space distance between resting position (RP) and the traction technique position, created three parameters of displacement - horizontal (x), vertical (y) and (l) - the resultant component.
Results: Parameters were not coherent with normal distribution. Statistical differences showed significance in the (x) parameter for IAOM AC compared with L AC (p<0,0183) and B AC (p<0,02). All techniques presented a significant increase of the resultant distance (l), compared with RP as the reference value - IAOM AC p<0,0036, L AC and B AC p<0,0000. In few cases L AC decreased the distance in the (x) parameter, but not significantly.
Conclusions:
1.Significant changes of (x) parameter did not correspond with the significance of the resultant parameter (l), which prevented authors from creating a classification of the techniques.
2.All traction techniques used in the study increased the joint space distance compared to RP, which confirms traction’s theoretical assumptions.
3.For clinical purpose the change of (x) parameter may prove crucial for therapy’s effectiveness, despite lack of change in the joint space distance in the resultant parameter (l) by itself.
The “CHILD” framework for the study of artisanal mercury mining communities
Authors: Van Brussel Evelyn , Carrizales Leticia , Flores-Ramirez Rogelio , Camacho Andrea , Leon-Arce Mauricio , Diaz-Barriga Fernando 
Published: March 2016

Abstract
In this paper, our group reports the use of a new framework in sites contaminated with mercury. This is significant because under the Minamata Convention on Mercury each Party shall endeavor to develop appropriate strategies for identifying and assessing sites contaminated by mercury or mercury compounds. This new approach, the “CHILD” framework has five steps: i) Community-based risk characterization; ii) Habilitation; iii) Intervention; iv) Laws and Regulation; and v) Development. We are using this framework in three mercury artisanal mining sites, and preliminary results are depicted in this report.
Arsenic projects in SE Asia
Authors: Navasumrit Panida , Chaisatra Krittinee , Ruchirawat Mathuros 
Published: March 2016

Abstract
Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of p53 in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary hOGG1 expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life.
Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
Authors: Scekic‐Zahirovic Jelena , Sendscheid Oliver , El Oussini Hajer , Jambeau Mélanie , Sun Ying , Mersmann Sina , Wagner Marina , Dieterlé Stéphane , Sinniger Jérome , Dirrig‐Grosch Sylvie , Drenner Kevin , Birling Marie‐Christine , Qiu Jinsong , Zhou Yu , Li Hairi , Fu Xiang‐Dong , Rouaux Caroline , Shelkovnikova Tatyana , Witting Anke , Ludolph Albert C , Kiefer Friedemann , Storkebaum Erik , Lagier‐Tourenne Clotilde , Dupuis Luc 
Published: March 2016

AbstractFUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often associated with concomitant loss of nuclear FUS. Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of both lead to neurodegeneration remains elusive. To address this question, we generated knockin mice expressing mislocalized cytoplasmic FUS and complete FUS knockout mice. Both mouse models display similar perinatal lethality with respiratory insufficiency, reduced body weight and length, and largely similar alterations in gene expression and mRNA splicing patterns, indicating that mislocalized FUS results in loss of its normal function. However, FUS knockin mice, but not FUS knockout mice, display reduced motor neuron numbers at birth, associated with enhanced motor neuron apoptosis, which can be rescued by cell‐specific CRE‐mediated expression of wild‐type FUS within motor neurons. Together, our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of function, but also triggers motor neuron death through a toxic gain of function within motor neurons.
suPAR level is associated with myocardial impairment assessed with advanced echocardiography in patients with type 1 diabetes with normal ejection fraction and without known heart disease or end-stage renal disease
Authors: Theilade Simone , Rossing Peter , Eugen-Olsen Jesper , Jensen Jan S , Jensen Magnus T 
Published: March 2016

Aim
Heart disease is a common fatal diabetes-related complication. Early detection of patients at particular risk of heart disease is of prime importance. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker for development of cardiovascular disease. We investigate if suPAR is associated with early myocardial impairment assessed with advanced echocardiographic methods.

Methods
In an observational study on 318 patients with type 1 diabetes without known heart disease and with normal left ventricular ejection fraction (LVEF) (biplane LVEF >45%), we performed conventional, tissue Doppler and speckle tracking echocardiography, and measured plasma suPAR levels. Associations between myocardial function and suPAR levels were studied in adjusted models including significant covariates.

Results
Patients were 55±12 years (mean±s.d.) and 160 (50%) males. Median (interquartile range) suPAR was 3.4 (1.7) ng/mL and LVEF was 58±5%. suPAR levels were not associated with LVEF (P=0.11). In adjusted models, higher suPAR levels were independently associated with both impaired systolic function assessed with global longitudinal strain (GLS) and tissue velocity s′, and with impaired diastolic measures a′ and e′/a′ (all P=0.034). In multivariable analysis including cardiovascular risk factors and both systolic and diastolic measures (GLS and e′/a′), both remained independently associated with suPAR levels (P=0.012).

Conclusions
In patients with type 1 diabetes with normal LVEF and without known heart disease, suPAR is associated with early systolic and diastolic myocardial impairment. Our study implies that both suPAR and advanced echocardiography are useful diagnostic tools for identifying patients with diabetes at risk of future clinical heart disease, suited for intensified medical therapy.
O Nascimento de um Herói: análise da segunda cena do acto primeiro da ópera Ulisses em Lisboa de Francisco José Freire
Authors: Mateus Rui Miguel 
Published: March 2016

A ópera de Cândido Lusitano, Ulisses em Lisboa, insere-se no Neoclassicismo e no contexto das Arcádias, nomeadamente da Arcádia Lusitana, da qual o autor fazia parte. Será aqui feito um breve estudo sobre o autor, a sua relevância para a literatura portuguesa e o seu papel no seio do período neoclássico. Propõe-se uma análise aprofundada de um excerto de Ulisses em Lisboa, enquadrado no primeiro acto. A segunda cena do primeiro acto pode ser estudada de um ponto de vista da cultura clássica, que serviu de influência a Cândido Lusitano. Tágio, a personagem em destaque na cena em análise, pode ser comparado com um pastor da Arcádia. O seu discurso alude a vários aspectos da vida na sociedade, tais como o nascimento e a família. Reunindo estes temas, defrontamo-nos com o vasto conhecimento que Francisco José Freire tinha da época clássica, da sua cultura, língua, religião e literatura.
Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast
Authors: Thierry Agnès , Khanna Varun , Dujon Bernard 
Published: March 2016

Abstract
Gene amplification has been observed in different organisms in response to environmental constraints, such as limited nutrients or exposure to a variety of toxic compounds, conferring them with specific phenotypic adaptations via increased expression levels. However, the presence of multiple gene copies in natural genomes has generally not been found in the absence of specific functional selection. Here, we show that the massive amplification of a chromosomal locus (up to 880 copies per cell) occurs in the absence of any direct selection, and is associated with low-order amplifications of flanking segments in complex chromosomal alterations. These results were obtained from mutants with restored phenotypes that spontaneously appeared from genetically engineered strains of the yeast Saccharomyces cerevisiae suffering from severe fitness reduction. Grossly extended chromosomes (macrotene) were formed, with complex structural alterations but sufficient stability to propagate unchanged over successive generations. Their detailed molecular analysis, including complete genome sequencing, identification of sequence breakpoints, and comparisons between mutants, revealed novel mechanisms causing their formation, whose combined action underlies the astonishing dynamics of eukaryotic chromosomes and their consequences.