bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the Green Cross method on patient safety culture in a postanaesthesia care unit: a longitudinal quasi-experimental study
Authors: Birkeli Gørill Helen , Thomas Owen Matthew Truscott , Deilkås Ellen Catharina Tveter , Ballangrud Randi , Lindahl Anne Karin 
Published: October 2024

BackgroundHospitals should adopt multiple methods to monitor incidents for a comprehensive review of the types of incidents that occur. Contrary to traditional incident reporting systems, the Green Cross (GC) method is a simple visual method to recognise incidents based on teamwork and safety briefings. Its longitudinal effect on patient safety culture has not been previously assessed. This study aimed to explore whether the implementation of the GC method in a postanaesthesia care unit changed nurses’ perceptions of different factors associated with patient safety culture over 4 years.MethodsA longitudinal quasi-experimental pre–post intervention design with a comparison group was used. The intervention unit and the comparison group, which consisted of nurses, were recruited from the surgical department of a Norwegian university hospital. The intervention unit implemented the GC method in February 2019. Both groups responded to the staff survey before and then annually between 2019 and 2022 on the factors ‘work engagement’, ‘teamwork climate’ and ‘safety climate’. The data were analysed using logistic regression models.ResultsWithin the intervention unit, relative to the changes in the comparison group, the results indicated significant large positive changes in all factor scores in 2019, no changes in 2020, significant large positive changes in ‘work engagement’ and ‘safety climate’ scores in 2021 and a significant medium positive change in ‘work engagement’ in 2022. At baseline, the comparison group had a significantly lower score in ‘safety climate’ than the intervention unit, but no significant baseline differences were found between the groups regarding ‘work engagement’ and ‘teamwork climate’.ConclusionThe results suggest that the GC method had a positive effect on the nurses’ perception of factors associated with patient safety culture over a period of 4 years. The positive effect was completely sustained in ‘work engagement’ but was somewhat less persistent in ‘teamwork climate’ and ‘safety climate’.
Hospitalisations for chronic conditions among care experienced and general population children and young people: evidence from the Children’s Health in Care in Scotland (CHiCS) cohort study, 1990–2016
Authors: Allik Mirjam , Gedeon Edit , Henderson Marion , Leyland Alastair 
Published: October 2024

ObjectiveThere is limited evidence on how the physical health of children and young people (CYP) who are care experienced (eg, in foster or out-of-home care) compares to the general population. UK research suggests that the prevalence of some chronic conditions may be similar for these groups.DesignWe undertook longitudinal population-wide data linkage of social care, prescription and hospitalisation records for care experienced and general population CYP born 1990–2004, followed from birth to August 2016. We compared prevalence estimates for asthma, diabetes (type 1) and epilepsy between the cohorts and used Poisson and survival models to estimate the association between social care and hospitalisations for these conditions.ResultsCare experience was not associated with a higher prevalence of asthma and diabetes, but epilepsy was more prevalent. Care was associated with increased hospitalisation rates for all three conditions, particularly for males. HRs for hospitalisations were highest before and after care and lower while the child was in care, for diabetes these were, respectively 1.88 (95% CI 1.28 to 2.77), 2.40 (95% CI 1.55 to 3.71) and 1.31 (95% CI 0.91 to 1.88) for care experienced CYP compared with general population.ConclusionsHospitalisations for chronic conditions are higher among care experienced CYP, particularly for males, and outside care episodes. Families with children with chronic conditions should be offered support to manage these conditions and help keep families together. Higher hospitalisations after care suggest that care leavers should be provided more support to help manage their health.
Using an integrated motor imagery and physical training intervention after knee injury: an interim analysis of the MOTIFS randomised controlled trial
Authors: Cederström Niklas , Nilsson Gustav , Dahan Rickard , Granér Simon , Ageberg Eva 
Published: October 2024

ObjectivesPhysical function is often a main focus of knee injury rehabilitation, but recent recommendations include increasing attention to psychological factors. We have developed the MOTor Imagery to Facilitate Sensorimotor re-learning (MOTIFS) training model which integrates dynamic motor imagery into physical rehabilitation. The objective is to report interim analysis results of an adaptive randomised controlled trial regarding the pre-defined continuation criteria.MethodsFollowing a 12-week intervention in which participants were randomised to either MOTIFS or Care-as-Usual training, n=42 people undergoing rehabilitation for a traumatic knee injury were assessed for change from baseline to follow-up in psychological readiness to return to activity, using the ACL Return to Sport after Injury Scale (ACL-RSI), and side hop limb symmetry index. Continuation criteria included differences of ≥5 points in ACL-RSI and ≥8 points in side hop limb symmetry index in favour of the MOTIFS group. If these were not met, ≥5 points change in enjoyment was acceptable.ResultsPre-defined continuation criteria were not met for ACL-RSI (mean difference −8.1 (SE 4.1)), side hop limb symmetry index (mean difference 4.4 (SE 7.8)), nor enjoyment (mean difference 3.9 (SE 4.5)), indicating that major modifications are required for continuation of the MOTIFS trial.ConclusionWhile results of this interim analysis did not show differences in psychological readiness to return to activity or side hop performance, previous research shows that the MOTIFS model is positive and enjoyable. Further research is warranted to evaluate more appropriate outcomes related to the holistic nature of physical and psychological readiness to return to activity.Trial registration numberNCT03473821.
Consumer product-related female genital injuries in the USA from 2013 to 2022
Authors: Li Kevin Danis , Al Azzawi Sultan , Hakam Nizar , Abbasi Behzad , Ghaffar Umar , Nwachukwu Chibuzor , Patel Hiren V , Breyer Benjamin N 
Published: October 2024

BackgroundConsumer product-related genital injuries in females across all age groups are understudied. Existing research focuses primarily on paediatric populations. We aimed to determine characteristics, trends and predictors of hospitalisation.MethodsThe National Electronic Injury Surveillance System database was queried for female genital injuries from 2013 to 2022. We stratified our population into four age groups (<18, 18–34, 35–54, >54 years). Automated text matching and manual reviews were employed for variable extraction. χ2tests and logistic regression were conducted, accounting for survey design and weights.Results9054 cases representing a national estimate of 252 329 injuries (95% CI 188 059 to 316 599) were identified. Paediatric injuries were most common (61%) and seniors had the highest hospitalisation rates (28%). Falls were common in paediatric (51%) and senior (48%) groups, whereas self-induced and topical application injuries were more frequent among adults aged 18–34 and 35–54. Injuries predominantly involved playground equipment and bicycles in children, razors and massage devices in adults aged 18–34 and 35–54 and household structures in seniors. Hospitalisation increased over the decade from 7% to 9%; significant predictors of hospitalisation were Asian race (OR=3.39, 95% CI 1.83 to 6.30), fractures (OR=7.98, 95% CI 4.85 to 13.1) and urethral injury (OR=3.15, 95% CI 1.30 to 7.63).ConclusionsOur study identifies distinct patterns in female genital injuries across ages. In the paediatric cohort, injuries are often linked to playgrounds and bicycles. For adults, grooming products are frequently implicated. Seniors commonly suffer injuries from household structures such as bathtubs. These patterns may inform discussions on tailored preventive strategies.
The correlation between intracranial pressure and venous sinus pressures changes after venous sinus stenting
Authors: Iyer Ankitha M , Midtlien Jackson P , Kittel Carol , Klever Lucas A , Wiater Angelina , Chang Emily , Margraf Connor , Fargen Kyle M 
Published: October 2024

BackgroundThe pathophysiology of idiopathic intracranial hypertension (IIH) and other cerebral venous outflow disorders (CVD) has largely been unexplored. While a correlation between venous sinus pressure and opening pressure (OP) has been previously noted, there are limited data on this relationship in patients with prior venous sinus stenting (VSS).MethodsA single center retrospective chart review was conducted on CVD patients who underwent diagnostic cerebral venography with manometry followed immediately by lateral decubitus lumbar puncture, from 2016 to 2024.Results206 patients underwent 216 total procedures and were included. Among all patients, there was a moderate nearly one-to-one correlation between OP and torcular or superior sagittal sinus (SSS) pressures. Thirty-two patients underwent testing after having undergone VSS. Patients with previous VSS showed a significantly altered relationship between venous pressures and OP, whereby as venous sinus pressures increased, OP increased more gradually in previously stented patients compared with non-stented patients. For example, when OP was fixed at 21 mm Hg and body mass index at 30 kg/m2, predicted mean SSS pressure was 19.47 mm Hg in non-stented patients versus 16.91 mm Hg in stented patients.ConclusionThis study confirmed a strong relationship between OP and venous sinus pressure in CVD patients. However, patients with previous VSS demonstrated an altered relationship with higher CSF pressures relative to venous pressures compared with naïve patients. This finding may have important clinical implications in the management of IIH patients.
Intra-arterial tenecteplase after successful endovascular therapy (ANGEL-TNK): protocol of a multicentre, open-label, blinded end-point, prospective, randomised trial
Authors: Huo Xiaochuan , Luo Gang , Sun Dapeng , Nguyen Thanh , Abdalkader Mohamad , Chen Wenhuo , Yao Xiaoxi , Yuan Guangxiong , Yi Tingyu , Han Hongxin , Pan Yuesong , Jovin Tudor G , Liebeskind David S , Liu Liping , Zhao Xingquan , Ren Zeguang , Wang Yilong , Wang Yongjun , Yan Bernard , Miao Zhongrong 
Published: October 2024

BackgroundDespite successful reperfusion after thrombectomy for large vessel occlusion (LVO) stroke, up to half of patients are dependent or dead at 3-month follow-up.The aim of the current study is to demonstrate safety and efficacy of administering adjunct intra-arterial (IA) tenecteplase in anterior circulation LVO patients who have achieved successful reperfusion defined as eTICI 2b50 to 3.MethodsANGEL-TNK is a multicentre, open-label, assessor-blinded endpoint, prospective randomised, controlled trial that will enrol up to 256 patients. Patients who meet inclusion criteria with anterior circulation LVO stroke and successful reperfusion will be randomised to receive IA tenecteplase or best medical management at 1:1 ratio.ResultsThe primary endpoint is a 90-day excellent outcome defined as modified Rankin Scale (mRS) 0–1. The primary safety endpoint is symptomatic intracranial haemorrhage within 48 hours from randomisation. Secondary endpoints include 90-day ordinal mRS, mRS 0–2, mRS 0–3, all-cause mortality and any intracranial haemorrhage.ConclusionIn patients with anterior circulation LVO stroke, the ANGEL-TNK trial will inform whether adjunct IA tenecteplase administered after successful thrombectomy reperfusion improves patient outcomes.Trial registration numberNCT05624190.
Geriatric falls: an enormous economic burden compared to firearms
Authors: Zangbar Bardiya , Rafieezadeh Aryan , Rodriguez Gabriel , Kirsch Jordan Michael , Shnaydman Ilya , Jose Anna , Bronstein Matthew , Prabhakaran Kartik 
Published: October 2024

BackgroundThis study aimed to assess the medical costs, and the combined costs of fatal firearm injury and fatal falls during a 5 year period. While fatal firearm injury represents a significant public health concern, the healthcare community is faced with the significant challenge of fatal falls, particularly in light of the elderly population growth.MethodsData were exported from the Web-based Injury Statistics Query and Reporting System database for fatal firearm and falls in patients aged between 15–85 years-old. The primary outcome was medical cost and the secondary outcome was combined costs (combination of medical costs and value of statistical life).ResultsThe medical cost of fatal falls was significantly higher in 2015–2020 in all age groups. The combined cost was significantly higher in fatal firearm injury overall. We found the combined cost was higher in fatal falls after 2019 for patients in the 45–85+ age range. During 2015–2019, the percentage of fatal falls had a significant increase in all age ranges, with a rise in the slope in 2019 for patients over 65 years. The annual percent change (APC) for the proportion of fatal falls increased from 2015 to 2020, there was a significant increase in the slope after 2019 (2.81% APC before 2019 vs 6.95% after 2019).ConclusionGeriatric fatal falls have significantly higher medical costs compared with fatal firearm injury. The combined cost for fatal falls exceeded fatal firearm injury after 2019 which highlights the increasing socioeconomic burden of an aging population.Level of evidenceLevel III retrospective study.
Technical Design Report for the LUXE experiment
Authors:   LUXE Collaboration, Abramowicz H. , Almanza Soto M. , Altarelli M. , Aßmann R. , Athanassiadis A. , Avoni G. , Behnke T. , Benettoni M. , Benhammou Y. , Bhatt J. , Blackburn T. , Blanch C. , Bonaldo S. , Boogert S. , Borysov O. , Borysova M. , Boudry V. , Breton D. , Brinkmann R. , Bruschi M. , Burkart F. , Büßer K. , Cavanagh N. , Dal Corso F. , Decking W. , Deniaud M. , Diner O. , Dosselli U. , Elad M. , Epshteyn L. , Esperante D. , Ferber T. , Firlej M. , Fiutowski T. , Fleck K. , Fuster-Martinez N. , Gadow K. , Gaede F. , Gallas A. , Garcia Cabrera H. , Gerstmayr E. , Ghenescu V. , Giorato M. , Golubeva N. , Grojean C. , Grutta P. , Grzelak G. , Hallford J. , Hartman L. , Heinemann B. , Heinzl T. , Helary L. , Hendriks L. , Hoffmann M. , Horn D. , Huang S. , Huang X. , Idzik M. , Irles A. , Jacobs R. , King B. , Klute M. , Kropf A. , Kroupp E. , Lahno H. , Lasagni Manghi F. , Lawhorn J. , Levanon A. , Levi A. , Levinson L. , Levy A. , Levy I. , Liberman A. , Liss B. , List B. , List J. , Lohmann W. , Maalmi J. , Madlener T. , Malka V. , Marsault T. , Mattiazzo S. , Meloni F. , Miron D. , Morandin M. , Moroń J. , Nanni J. , Neagu A. T. , Negodin E. , Paccagnella A. , Pantano D. , Pietruch D. , Pomerantz I. , Pöschl R. , Potlog P. M. , Prasad R. , Quishpe R. , Ranken E. , Ringwald A. , Roich A. , Salgado F. , Santra A. , Sarri G. , Sävert A. , Sbrizzi A. , Schmitt S. , Schulthess I. , Schuwalow S. , Seipt D. , Simi G. , Soreq Y. , Spataro D. , Streeter M. , Swientek K. , Tal Hod N. , Teter T. , Thiebault A. , Thoden D. , Trevisani N. , Urmanov R. , Vasiukov S. , Walker S. , Warren M. , Wing M. , Yap Y. C. , Zadok N. , Zanetti M. , Żarnecki A. F. , Zbińkowski P. , Zembaczyński K. , Zepf M. , Zerwas D. , Ziegler W. , Zuffa M. 
Published: October 2024

AbstractThis Technical Design Report presents a detailed description of all aspects of the LUXE (Laser Und XFEL Experiment), an experiment that will combine the high-quality and high-energy electron beam of the European XFEL with a high-intensity laser, to explore the uncharted terrain of strong-field quantum electrodynamics characterised by both high energy and high intensity, reaching the Schwinger field and beyond. The further implications for the search of physics beyond the Standard Model are also discussed.
An Emotional Dialogue System Using Conditional Generative Adversarial Networks with a Sequence-to-Sequence Transformer Encoder
Authors: Huang Wen-Chieh , Hsueh Yu-Ling 
Published: October 2024

Understanding the expression of emotion and generating appropriate responses are key steps toward constructing emotional, conversational agents. In this article, we propose a framework for single-turn emotional conversation generation, and there are three main components in our model, namely, a sequence-to-sequence model with stacked encoders, a conditional variational autoencoder, and conditional generative adversarial networks. For the sequence-to-sequence model with stacked encoders, we designed a two-layer encoder by combining Transformer with gated recurrent units-based neural networks. Because of the flexibility of the sequence-to-sequence model, we adopted a conditional variational autoencoder in our framework, which uses latent variables to learn a distribution over potential responses and generates diverse responses. Furthermore, we regard a conditional variational autoencoder-based, sequence-to-sequence model as the generative model, and the training of the generative model is assisted by both a content discriminator and an emotion classifier, which assists our model in promoting content information and emotion expression. We use automated evaluation and human evaluation to evaluate our model and baselines on the NII Test Collections for IR Systems short-text conversation task Chinese emotional conversation generation Subtask dataset [
44
], and the experimental results demonstrate that our proposed framework can generate semantically reasonable and emotionally appropriate responses.
Resistance Management for Cancer: Lessons from Farmers
Authors: Seyedi Sareh , Harris Valerie K. , Kapsetaki Stefania E. , Narayanan Shrinath , Saha Daniel , Compton Zachary , Yousefi Rezvan , May Alexander , Fakir Efe , Boddy Amy M. , Gerlinger Marco , Wu Christina , Mina Lida , Huijben Silvie , Gouge Dawn H. , Cisneros Luis , Ellsworth Peter C. , Maley Carlo C. 
Published: October 2024

Abstract
One of the main reasons we have not been able to cure cancers is that treatments select for drug-resistant cells. Pest managers face similar challenges with pesticides selecting for pesticide-resistant insects, resulting in similar mechanisms of resistance. Pest managers have developed 10 principles that could be translated to controlling cancers: (i) prevent onset, (ii) monitor continuously, (iii) identify thresholds below which there will be no intervention, (iv) change interventions in response to burden, (v) preferentially select nonchemical control methods, (vi) use target-specific drugs, (vii) use the lowest effective dose, (viii) reduce cross-resistance, (ix) evaluate success based on long-term management, and (x) forecast growth and response. These principles are general to all cancers and cancer drugs and so could be employed broadly to improve oncology. Here, we review the parallel difficulties in controlling drug resistance in pests and cancer cells. We show how the principles of resistance management in pests might be applied to cancer. Integrated pest management inspired the development of adaptive therapy in oncology to increase progression-free survival and quality of life in patients with cancers where cures are unlikely. These pest management principles have the potential to inform clinical trial design.
Data from Blood Magnesium Level and Risk of Hepatocellular Carcinoma in a Prospective Liver Cirrhosis Cohort
Authors: Zhang Xinyuan , Zhao Longgang , Dai Qi , Hou Tao , Danford Christopher J. , Lai Michelle , Zhang Xuehong 
Published: October 2024

<div>AbstractBackground:<p>Higher magnesium intake was linked to a lower risk of hepatocellular carcinoma (HCC). However, the relationship between blood magnesium level and HCC has not been fully characterized, especially among patients with liver cirrhosis who are at a higher risk for HCC.</p>Methods:<p>In the Mass General Brigham Biobank, we developed a new prospective cohort of 1,430 patients with liver cirrhosis without liver cancer history using the validated International Classification of Diseases codes. We used Cox proportional hazards models to generate hazard ratios (HRs) with 95% confidence intervals (CI) for incident HCC and used generalized estimating equations to compare changes in liver biomarkers according to baseline blood magnesium, adjusting for age, sex, race, lifestyles, body mass index, type 2 diabetes, model for end-stage liver disease score, and hepatitis infection.</p>Results:<p>During a median follow-up period of 4.26 years, 109 patients developed HCC. Magnesium deficiency (<1.70 mg/dL; <i>N</i> = 158) was associated with a higher risk of HCC (HR = 1.93; 95% CI, 1.12–3.30) compared with magnesium sufficiency (≥1.70 mg/dL; <i>N</i> = 1282). This association remained robust in the 1-year lag analysis (HR = 2.18; 95% CI, 1.11–4.28) and in sensitivity analysis excluding patients with alcoholic liver disease (HR = 2.41; 95% CI, 1.23–4.74). Magnesium in the lowest quartile was associated with a faster increase in alanine transaminase (β = 4.35; 95% CI, 1.06–7.63), aspartate aminotransferase (β = 6.46; 95% CI, 0.28–12.6), direct bilirubin (β = 0.18; 95% CI, 0.01–0.35), and total bilirubin (β = 0.21; 95% CI, 0.03–0.39), compared with the highest quartile.</p>Conclusions:<p>Lower blood magnesium level is associated with higher HCC risk and unfavorable liver biomarker changes.</p>Impact:<p>If confirmed, our findings may potentially enable better identification of high-risk patients for HCC and inform better management strategies for liver cirrhosis.</p></div>
Liver Cancer: Progress and Priorities
Authors: McGlynn Katherine A. , Petrick Jessica L. , Groopman John D. 
Published: October 2024

Abstract
Liver cancer, the sixth most frequently occurring cancer in the world and the third most common cause of cancer mortality, has wide geographical variation in both incidence and mortality rates. At the end of the 20th century, incidence rates began declining in some high-rate areas and increasing in some lower-rate areas. These trends were undoubtedly driven by the shifting contributions of both well-established and more novel risk factors. While notable strides have been made in combating some major risk factors, such as hepatitis B virus and hepatitis C virus, the emergence of metabolic conditions as important drivers of liver cancer risk indicates that much work remains to be done in prevention. As liver cancer is strongly associated with economic and social deprivation, research, early-diagnosis, and treatment among disadvantaged populations are of paramount importance.