bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elastase-2 knockout mice display anxiogenic‐ and antidepressant-like phenotype: putative role for BDNF metabolism in prefrontal cortex
Authors: Diniz CRAF , Becari C , Lesnikova A , Biojone C , Salgado MCO , Salgado HC , Resstel LBM , Guimaraes FS , Castren E , Casarotto PC , Joca SRL 
Published: September 2017

AbstractSeveral pieces of evidence indicate that elastase-2 (ELA2; chymotrypsin-like ELA2) is an alternative pathway to the generation of angiotensin II (ANG II). Elastase-2 knockout mice (ELA2KO) exhibit alterations in the arterial blood pressure and heart rate. However, there is no data on the behavioral consequences of ELA2 deletion. In this study we addressed this question, submitting ELA2KO and wild-type (WT) mice to several models sensitive to anxiety‐ and depression-like, memory, and repetitive behaviors. Our data indicates a higher incidence of barbering behavior in ELA2KO compared to WT, as well as an anxiogenic phenotype, evaluated in the elevated plus maze (EPM). While a decrease in locomotor activity was observed in ELA2KO in EPM, this feature was not the main source of variation in the other parameters analyzed. The marble burying test (MBT) indicated increase in repetitive behavior, observed by a higher number of buried marbles. The actimeter test indicated a decrease in total activity and confirmed the increase in repetitive behavior. The spatial memory was tested by repeated exposure to the actimeter in a 24h interval. Both ELA2KO and WT exhibited decreased activity compared to the first exposure, without any distinction between the genotypes. However, when submitted to the cued fear conditioning, ELA2KO displayed lower levels of freezing behavior in the extinction session when compared to WT, but no difference was observed during the conditioning phase. Increased levels of BDNF were found in the prefrontal cortex but not in the hippocampus of ELA2KO mice compared to WT. Finally, in silico analysis indicates that ELA2 is putatively able to cleave BDNF, and incubation of the purified enzyme with BDNF led to the degradation of the later. Our data suggested an anxiogenic‐ and antidepressant-like phenotype of ELA2KO, possibly associated with increased levels of BDNF in the prefrontal cortex.
Multispecies coalescent analysis unravels the non-monophyly and controversial relationships of Hexapoda
Authors: Freitas Lucas A. , Mello Beatriz , Schrago Carlos G. 
Published: September 2017

AbstractWith the increase in the availability of genomic data, sequences from different loci are usually concatenated in a supermatrix for phylogenetic inference. However, as an alternative to the supermatrix approach, several implementations of the multispecies coalescent (MSC) have been increasingly used in phylogenomic analyses due to their advantages in accommodating gene tree topological heterogeneity by taking account population-level processes. Moreover, the development of faster algorithms under the MSC is enabling the analysis of thousands of loci/taxa. Here, we explored the MSC approach for a phylogenomic dataset of Insecta. Even with the challenges posed by insects, due to large effective population sizes coupled with short deep internal branches, our MSC analysis could recover several orders and evolutionary relationships in agreement with current insect systematics. However, some phylogenetic relationships were not recovered by MSC methods. Most noticeable, a remiped crustacean was positioned within the Insecta. Additionally, the interordinal relationships within Polyneoptera and Neuropteroidea contradicted recent works, by suggesting the non-monophyly of Neuroptera. We notice, however, that these phylogenetic arrangements were also poorly supported by previous analyses and that they were sensitive to gene sampling.
hmmIBD: software to infer pairwise identity by descent between haploid genotypes
Authors: Schaffner Stephen F. , Taylor Aimee R. , Wong Wesley , Wirth Dyann F. , Neafsey Daniel E. 
Published: September 2017

AbstractSummaryWe introduce hmmIBD, software to estimate pairwise identity by decent between haploid genomes, such as those of the malaria parasite, sampled from one or more populations. We verified hmmIBD using simulated data, benchmarked it against a previously published method for detecting IBD within populations, and demonstrated its utility usingPlasmodium falciparumdata from Cambodia and Ghana.Supplementary informationSupplementary data include Appendices S1, S2 and S3, and are available online.Availability and ImplemetationSource code written in C99/C11-compliant C and requiring no external libraries, is freely available for download athttps://github.com/glipsnort/hmmIBD/releases, alongside test datasets.Contactsfs@broadinstitute.org
Corporate social responsibility (CSR) for ethical corporate identity management
Authors: Wong Jia Yun , Dhanesh Ganga Sasidharan 
Published: September 2017

PurposeThe purpose of this paper is to examine the framing and rhetorical devices employed by luxury brands to build CSR-based, ethical corporate identities while managing complexities of the CSR-luxury paradox, the perceived clash between the self-transcendent values of CSR, and the self-enhancement values of luxury.Design/methodology/approachQualitative frame analysis was conducted to create detailed frame matrices for each dimension of CSR message content, followed by quantitative content analysis to establish the extent of usage of these frames across 43 luxury brand websites in the apparel, beauty, jewelry, and watch categories.FindingsLuxury brands predominantly framed their CSR efforts as discretionary, driven by altruistic motives. They foregrounded brand over social issue and highlighted substantial input into CSR efforts consistently over a period. CSR efforts were put into programs that were congruent with the brands’ business and that conveyed impact in abstract terms, evoking emotions over logic. Such framing across the CSR message-dimensions of issues, motives, importance, commitment, fit, and impact reflected a sophisticated understanding of communicating to a socially and environmentally conscious demographic while simultaneously aligning with the central, enduring, and distinctive characteristics of luxury.Originality/valueThis study contributes to emerging empirical work on CSR as a tool to build ethical corporate identity. This study also adds to the literature on identity management and CSR communication in the luxury industry, a sector that exceeded €1 trillion in retail sales in 2016.
Professor Ruth Simpson, Sydney Ruth and gendering management
Authors: Pullen Alison , Ross-Smith Anne 
Published: September 2017

Purpose
This paper aims to review Ruth Simpson’s contribution to the field of gender and management.

Design/methodology/approach
This paper looks at Ruth Simpson’s body of work over her career through a conversation that took place between Pullen and Ross-Smith.

Findings
Ruth Simpson’s contribution to gender, class, work and organizations is discussed.

Originality/value
This piece remembers Ruth Simpson’s feminist scholarship to the field of gender and management.
Reference to healthy food menu on iOS platform
Authors: Fajri Arrad , Salman Afan Galih 
Published: September 2017

Purpose
The purpose of this study is to build an iOS-based application to provide quick and easy access to information on food and beverages that are tailored to an illness.

Design/methodology/approach
The method used is the method of analysis, i.e. collect the necessary data from various sources that contain the issues to be examined. Software development life cycle used the Waterfall Model that has seven stages to its completion: the requirements analysis and specification, architectural design, detailed design, coding, unit testing, integration testing and system testing and acceptance.

Findings
Existing applications were evaluated from the user point of view. The evaluation was performed by 25 users trying directly on the application. After conducting experiments on the application, users were asked to answera questionnaire that included questions on the problems they may have faced and whether the problem was solved. The results of user evaluation were as follows: 72 per cent of users found that the application view is quite good and 88 per cent of users felt the speed and ease of getting enough information.

Originality/value
The authors report that the development of the application reference, menu of healthy food on the IOS platform, can make users get a healthy diet and abortion based on the illness quickly and easily.
Internal auditors’ reputation and managers’ reliance decision
Authors: Tang Fengchun , Yang Ling , Gan Huiqi 
Published: September 2017

PurposeThe purpose of this paper is to investigate how internal auditors’ performance reputation for auditing and assurance engagements affects corporate managers’ reliance on their consulting recommendations.Design/methodology/approachThis study conducted a 2 × 2 between-subjects experiment in which 103 MBA students were randomly assigned to one of the four conditions. This paper uses analysis of covariance to analyze the data.FindingsThe results show that internal auditors’ reputation for performing assurance engagements positively influences managers’ reliance on their consulting recommendations. In addition, managers’ compensation structure affects their perceptions of the importance of the decision, and the perceived decision importance in turn partially moderates the effect of internal auditors’ performance reputation on managers’ reliance decision.Research limitations/implicationsThis paper advances the understanding of the consulting function of the internal audit function (IAF) and provides evidence on how internal auditors’ performance in one field (assurance) affects management’s perception of their performance in the other field (consulting).Practical implicationsThe findings of this paper should be particularly interesting to the parties that are responsible for training internal auditors by highlighting the importance of strengthening internal auditors’ capability of performing consulting service with respect to business operation.Originality/valueThis study is one of the few studies that examine how internal auditors’ consulting recommendations affect managerial decisions in an operational setting. The findings of the interdependence between the assurance and consulting components of the IAF advance the growing research stream of internal audit and its impact on management decision-making.
A global analysis of elevational gradients in leaf herbivory and its underlying drivers: Effects of plant growth form, leaf habit and climatic correlates
Authors: Galmán Andrea , Abdala‐Roberts Luis , Zhang Shuang , Berny‐Mier y Teran Jorge C. , Rasmann Sergio , Moreira Xoaquín 
Published: September 2017

Abstract

Research on elevational gradients in species interactions holds that herbivore pressure increases towards warmer and more stable climates found at lower elevations. However, the generality of this expectation has been challenged by recent studies reporting no evidence of expected trends or even positive associations between elevation and herbivory, presumably due to uncontrolled biotic and abiotic factors influencing such relationships.

Using a world‐wide dataset of insect leaf herbivory including 1,027 plant species and spanning an elevation gradient of 2,755 m, we tested if elevational gradients in herbivory were contingent on whether species were found at tropical vs. temperate latitudes, plant growth form (non‐woody vs. woody species), and leaf habit (deciduous vs. evergreen woody species). In addition, we tested the influence of climatic correlates of elevation presumably underlying such elevational gradients.

Although there was no evidence of an overall relationship between elevation and damage, we found that elevational gradients in herbivory were contingent on species growth form whereby herbivory increased towards lower elevations for woody species, but no gradient was observed for non‐woody species. We further found that elevational gradients in herbivory were contingent on leaf habit as herbivory increased towards lower elevations for deciduous species, but no gradient was present for evergreen species. Elevational variation in damage was not contingent upon latitudinal region. Finally, analyses of climatic factors indicated that although a significant association between temperature and herbivory for woody species was detected, the elevational gradient in leaf herbivory remained largely unchanged after accounting for temperature and precipitation, suggesting that climate does not fully account for the gradient.

Synthesis. This study delivers the first global assessment of elevational gradients in leaf herbivory and emphasizes the role of plant (e.g. life‐history or defensive) traits and climatic factors in shaping elevational gradients in herbivory.
The Formation of GM‐free and GM Coasean Clubs: Will They Form and If So How Much Can They Achieve?
Authors: Punt Maarten J. , Wesseler Justus 
Published: September 2017

AbstractThe unintended presence of traces of genetically modified (GM) crops in the harvests of non‐GM crops plays a prominent role in the debate over the coexistence of GM and non‐GM crops. One way to address the issue is the formation of GM‐free or GM‐only clubs. We model the decisions of individual farmers to cultivate either GM or non‐GM crops and combine this with a game theoretic model of club formation to investigate the feasibility of such clubs. We consider two liability regimes: GM farmers are liable or they are not. We consider two benchmarks: Nash equilibrium without negotiations and the efficient allocation and compare those with partial co‐operation through a Coasean club. We find that in both regimes a relatively large club can form but they are not always necessary to reach the efficient allocation. In fact, if farmers can freely decide under profit maximisation what to cultivate, they reach 95% of an efficient allocation. This holds independent of the property rights system and provides strong support for coexistence policies based on ex‐post liability such as in the US and Spain.
Incidence and control of black spot syndrome of tiger nut
Authors: Alvares D. , Armero C. , Forte A. , Serra J. , Galipienso L. , Rubio L. 
Published: September 2017

ABSTRACTTiger nut (Cyperus esculentum) is a very profitable crop in Valencia, Spain, but in the last years, part of the harvested tubers presents black spots in the skin making them unmarketable. Surveys performed in two consecutive years showed that about 10% of the tubers were severely affected by the black spot syndrome whose aetiology is unknown. Disease control procedures based on selection of tubers used as seed (seed tubers) or treatment with hot‐water and/or chemicals were assayed in greenhouse. These assays showed that that this syndrome had a negative impact on the germination rate, tuber size and yield. Selection of asymptomatic seed tubers reduced drastically the incidence of the black spot syndrome with respect to using seed tubers with severe symptoms (selection of healthy seed tubers was not possible because the causal agent is undetermined). Thermal treatment of seed tubers with severe symptoms reduced the number of unmarketable harvested tubers by half but was detrimental for the germination. Chemical treatments of seed tubers with severe symptoms decreased the incidence of the black spot syndrome about 40% for sodium hypochlorite and about 10% for hydrochloric acid, trisodium phosphate and the fungicide trioxystrobin.
Public health agencies’ obligations and the case of Zika
Authors: Luna Florencia 
Published: September 2017

AbstractThis article focuses on the initial reactions to the Zika epidemic by national and international public health agencies. It presents and analyzes some responses public officials made about sexual and reproductive health at the inception of the epidemic. It also describes the different challenges and obligations faced by local and international public health agencies, as these have not been clearly outlined. The article argues that these agencies have different obligations and should fulfill them despite existing obstacles. While international agencies should honor their leadership role and make recommendations at a meta‐level, local agencies should provide, in the case of Zika, a framework for empowerment and grant women the freedom to achieve sexual and reproductive health so that they can avoid the consequences of this epidemic.
A mindfulness‐based group for young people with learning disabilities: A pilot study
Authors: Thornton Victoria , Williamson Rachel , Cooke Bronwen 
Published: September 2017

Accessible summary

This study talks about a group for young people with learning disabilities

The group helped the young people to practice mindfulness.

Mindfulness practices can help when we feel worried, angry or upset.

The young people in the group gave really helpful feedback that will help to make the next group even better.

AbstractBackgroundMindfulness is becoming increasingly reported as an effective way to support well‐being and reduce mental health difficulties.Materials and MethodsThis study reports on the development and pilot of a mindfulness‐based group for young people with learning disabilities and their carers.ResultsGroup participants reported that the group was helpful. Reports from carers show that the young people continued to use mindfulness‐based practices in their daily lives even after the completion of the group.ConclusionMindfulness can be effective and accessible for young people with learning disabilities. More research is needed to increase our understanding of how and why participation in a mindfulness‐based group is helpful to young people with learning disabilities.
Pharmacology of cognition: a panacea for neuropsychiatric disease?
Authors: Bailey Sarah J , Neill Joanna C , Moran Paula M 
Published: September 2017

Linked ArticlesThis article is part of a themed section on Pharmacology of Cognition: a Panacea for Neuropsychiatric Disease? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.19/issuetoc
Growing Food, Growing Consciousness: Gardening and Social Justice in Grand Rapids, Michigan
Authors: Mello Christina , King Lisa Oliver , Adams Inez 
Published: September 2017

AbstractOur Kitchen Table (OKT) is a female‐led organization that advocates on behalf of women with children as well as low‐income earners afflicted by food insecurity and environmental health disparities in Southeast Grand Rapids, MI. OKT created the Food Diversity Project (FDP) to address the structural causes of these disparities. Premised on the principle of food justice, the FDP supplies community members with the tools and the education that they need to take ownership of their food system, while also addressing structural racism. Organizational activities focus on the relationship between growing food and reducing exposure to environmental toxins. Residents are informed about environmental threats linked to food insecurity and equipped with skills in agriculture and activism to effectively address these problems within their households and beyond. In this report, the founding member and consulting anthropologists outline the instrumental importance of this work, as well as provide a summary of the FDP, its activities, and measurable outcomes.
Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy
Authors: Espinel Danielle P.G.S. , Di Giacomo Thais B. , Pincelli Thais P. , Pereira Naiura V. , Sotto Miriam N. , Kirsner Robert S. , Criado Paulo R. 
Published: September 2017

BackgroundCoagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV.ObjectivesTo investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV.MethodsSkin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry.ResultsWe found that lesional skin in patients with LV expressed 10‐fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P = .02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV.ConclusionsIncreased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo‐occlusive vasculopathy observed in this disease.
Referral population studies underestimate differences between human papillomavirus assays in primary cervical screening
Authors: Rebolj M. , Njor S. , Lynge E. , Preisler S. , Ejegod D. , Rygaard C. , Bonde J. 
Published: September 2017

ObjectiveWe studied how representative cytologically abnormal women (“referral populations”) are with respect to uncovering differences between human papillomavirus (HPV) assays in the primary screening where most women are cytologically normal.MethodsA total of 4997 women were tested with SurePath® cytology, and Hybrid Capture 2 (HC2), cobas, CLART and APTIMA HPV assays. Women with positive test results were offered a follow‐up. For all detected HPV infections and HPV‐positive high‐grade cervical intraepithelial neoplasia (≥CIN2), we studied the distributions of assay‐specific signal strengths in the baseline samples as documented by the assays’ automatically generated reports. We calculated the likelihood of test result discordance as the proportion of HPV‐positive samples that were not confirmed by all four assays.ResultsMedian signal strengths for HPV infections were weaker in normal than abnormal cytology (P<.001, adjusted for women's age, multiple infections and the reason for taking the sample). For HC2, they were RLU/CO 11.0 (interquartile range, IQR: 3.3‐52.8) vs 124.2 (IQR: 22.8‐506.9), respectively; for cobas, Ct 33.5 (IQR: 29.6‐37.5) vs 26.9 (IQR: 23.7‐31.3), respectively; for APTIMA, S/CO 10.2 (IQR: 5.8‐11.3) vs 11.1 (IQR: 9.4‐15.5), respectively. Similar patterns were observed for HPV‐positive ≥CIN2. The four HPV assays more frequently returned discordant test results in normal than in abnormal cytology. Relative frequency of discordance in detecting HPV infections was 0.39 (95% confidence interval: 0.33‐0.48) for abnormal vs normal cytology.ConclusionsThese data suggest that referral population studies, by not including sufficient numbers of cytology normal women, underestimate the differences between HPV assays that would become apparent in primary screening.