bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of aescin with β- and γ-cyclodextrins studied by DFT calculations and spectroscopic methods
Authors: Ramos Ana I , Vaz Pedro D , Braga Susana S , Silva Artur M S 
Published: February 2017

Background: Aescin, a natural mixture of saponins occurring in Aesculus hippocastanum, exhibits important flebotonic properties, being used in the treatment of chronic venous insufficiency in legs. The inclusion of aescin into cyclodextrins (CDs) is a technical solution for its incorporation into the textile of stockings, but details of the physicochemistry of these host–guest systems are lacking. This work investigates the inclusion of aescin into the cavities of two native cyclodextrins, β-CD and γ-CD.Results: The continuous variation method applied to aqueous-phase 1H nuclear magnetic resonance (1H NMR) has demonstrated that the preferred CD/aescin inclusion stoichiometries are 2:1 with β-CD and 1:1 with γ-CD. The affinity constant calculated for γ-CD·aescin was 894 M−1, while for 2β-CD·aescin it was estimated to be 715 M−1. Density functional theory (DFT) calculations on the interaction of aescin Ib with CDs show that an inclusion can indeed occur and it is further demonstrated that the wider cavity of γ-CD is more adequate to accommodate this large guest. ROESY spectroscopy is consistent with the formation of a complex in which the triterpenic moiety of aescin is included into the cavity of γ-CD. The higher stability of this geometry was confirmed by DFT. Furthermore, DFT calculations were applied to determine the chemical shifts of the protons H3 and H5 of the CDs in the optimised structures of the inclusion complexes. The calculated values are very similar to the experimental data, validating the approach made in this study by NMR.Conclusion: The combination of experimental data from aqueous-state NMR measurements and theoretical calculations has demonstrated that γ-CD is the most suitable host for aescin, although the inclusion also occurs with β-CD. The geometry of the γ-CD·aescin complex is characterised by the inclusion of the triterpene segment of aescin into the host cavity.
1 brybry dans le bidou . Le vocabulaire des forums sur la grossesse et la procréation médicalement assistée : représentations de la norme et communautés
Authors: Raschini Elisa 
Published: February 2017

Certains forums français de discussions consacrés à la grossesse ou à la procréation médicalement assistée montrent que les énonciatrices – toutes des femmes – peuvent parfois employer des mots tels brybry , gygy , fofos , zozos , zhom pour parler de l’embryon, du gynécologue, des follicules, des spermatozoïdes, des hommes leurs compagnons.	Cet article s’interroge sur la façon dont ces énonciatrices envisagent l’emploi d’un tel vocabulaire par rapport à ce qu’elles peuvent considérer comme la norme linguistique, ainsi que par rapport à la communauté à laquelle elles peuvent s’identifier. L’approche de folk linguistique permet de dégager plusieurs points de vue : d’une part, ce vocabulaire, qui n’a pas encore intégré le système de la langue standard, peut quand même être perçu comme normal, voire comme prescriptif dans le dispositif de communication (le forum de discussion) utilisé par ces énonciatrices ; d’autre part, ce même vocabulaire peut parfois être considéré comme moralement blâmable par rapport à la rectitude perçue de la langue standard ; enfin, il peut être pensé comme un élément important pour assurer la cohésion d’une communauté discursive, qui se définit ici par le dispositif de communication, mais aussi et surtout par le genre et l’expérience corporelle, réelle ou souhaitée, de la grossesse.
La Sacralisation littéraire et picturale de la montagne au XIXe siècle : (re)naissances et épiphanies
Authors: Dupeyron-Lafay Françoise 
Published: February 2017

Mountains, that had been objects of indifference, fear, or even terror and loathing until the mid-18th century, became literary and pictorial subjects in their own right from the Romantic period onwards, especially in the wake of Rousseau’s La Nouvelle Héloïse (1761)—that radically changed the approach to nature—, and the first ascents of Mont Blanc in the 1780s that marked the beginning of Alpine tourism, and turned Chamonix (and later the Swiss Alps) into indispensable features of the "Grand Tour". We shall see the various—and sometimes complementary and converging—approaches to mountains from the late 18th century on: those emphasizing their pristine, Edenic nature; those extolling their power, sublimity and elemental violence, Turner’s paintings being emblematic in this respect : and those bringing out their divine essence, their sacred and holy quality. The corpus will mainly pertain to the latter category and through the study of Novalis, De Quincey, Ruskin, and Caspar David Friedrich’s paintings, we shall discover stories of birth and rebirth, regeneration and redemption. In the works of these authors, mountains—whether real or merely imaginary, whether the results of experience or pure fantasy—are nevertheless the locus of intense epiphanies leading to the advent of the self as true individual and artist
Winter, Montana: the Mountain Literature of Rick Bass
Authors: Gavillon François 
Published: February 2017

La montagne et l’hiver—partout présents dans les œuvres de Rick Bass—ne figurent jamais un simple décor pour activité récréative. Au contraire, ils apparaissent comme des composantes majeures dans l’existence des personnages comme dans l’économie générale des textes : non pas seulement un environnement mais un lieu où résider et travailler, un lieu d’écriture aussi et de conscience affinée. Cette étude a pour objet d’examiner le rôle des deux topoi comme constitutifs d’une "poétique" bassienne de la montagne hivernale : la montagne comme lieu, comme temporalité, comme force agissante, comme art enfin. On y apercevra aussi les avatars successifs de l’auteur—géologue, écrivain, activiste et homme des bois—maniant les rhétoriques combinées du discours scientifique, de la fiction merveilleuse et de la non-fiction prophétique
Parker Mountain, or the Geography of Pathos in Russell Banks’s Affliction (1989)
Authors: Omhovère Claire 
Published: February 2017

Les romans de Russell Banks confèrent à la géographie une importance qui va bien au delà des fonctions mimétique et métonymique habituellement remplies par un simple décor. Dès la première lecture d’Affliction, il est manifeste que la géographie ne sert pas seulement à transposer l’espace en images, ni même à fournir un fond à l’intrigue, mais qu’elle contribue pleinement à la cohérence spatio-narrative du roman. Cet article s’attachera donc tout particulièrement à étudier les perturbations qu’introduit la représentation de la montagne dans le régime réaliste du roman. A travers Parker Mountain, Banks convoque en effet les terreurs et aspirations qui s’expriment à travers deux traditions populaires : l’univers fabuleux du conte et le récit de la frontière. Il s’agira ici de montrer comment Banks joue sur les attentes génériques du lecteur pour provoquer une réflexion sur la violence que les sociétés humaines visent à contenir
City of Wars: the Representation of Wartime London in Two Novels of the 1940s: James Hanley’s No Directions and Patrick Hamilton’s The Slaves of Solitude
Authors: Murat Jean-Christophe 
Published: February 2017

Cette étude analyse la représentation de la ville anglaise en guerre—ou plus exactement de Londres et de sa banlieue—dans deux romans britanniques des années quarante : No Directions de James Hanley (1943), et The Slaves of Solitude de Patrick Hamilton (1947). Aucun de ces deux textes ne doit être considéré comme un documentaire sur l’existence urbaine pendant la Seconde Guerre mondiale. No Directions entretient des liens assez forts avec la rhétorique et les images—alors à très la mode—des Poètes de la Nouvelle Apocalypse (New Apocalyptic poetry) ; l’expérimentation formelle et linguistique y est donc omniprésente, frisant même l’artificiel par endroits. En apparence, The Slaves of Solitude est un roman plus conventionnel ; pourtant sa langue et son univers sont profondément polyphoniques. No Directions fut écrit et publié alors que la guerre n’était pas encore terminée, ce qui crée un véritable suspense quant à l’issue du conflit et aux orientations de la société anglaise. Le roman de Hamilton, au contraire, est postérieur à 1945, ce qui permet sans doute à l’auteur de faire preuve d’un sens de l’humour et de l’ironie assez déroutant. Dans les deux romans, la guerre est vécue non par des militaires mais par des civils et des non-combattants : No Directions représente le point de vue des occupants d’un immeuble d’habitation de Chelsea, à Londres, au cours d’un raid aérien nocturne. The Slaves of Solitude choisit de décentrer l’action vers la banlieue lointaine—et fictive—de Thames Lockdon, qui accueille des Londoniens évacués par les bombardements. Alors que le roman de Hanley est un récit de l’expérience directe de la guerre (la terreur des attaques aériennes, les va-et-vient entre la cave et les appartements...), la terne pension où cohabitent les personnages de The Slaves est le théâtre d’une bien plus insidieuse guerre des mots, par laquelle Miss Roach, la protagoniste, se livre à un examen impitoyable—mais pas toujours lucide—des enjeux de la fidélité et de la trahison (des amis, puis de la nation).
Symbolic versus Practical Reconciliation between Mainstream and Indigenous Australian Economies
Authors: Oost Victor 
Published: February 2017

Le gouvernement fédéral de John Howard met en œuvre, depuis quelques années, une politique fondée sur "l’obligation mutuelle," c’est-à-dire l’obligation de réciprocité dans ses rapports avec les communautés indigènes. Comment ce volet de ce que le Premier Ministre a appelé "la réconciliation pratique" va-t-il influer sur le processus de réconciliation nationale symbolique, préconisée par le gouvernement Hawke en 1991? Derrière l’objectif avoué de résultats concrets sur le terrain, certains leaders aborigènes y voient le retour des politiques d’assimilation des années cinquante. D’autres chefs, tel Noël Pearson, accueillent favorablement cette rupture d’avec l’aide sociale et la dépendance qu’elle crée, puisqu’on met l’accent sur la responsabilité collective des Aborigènes.Jusqu’à ce que le parti de John Howard soit élu en 1996, la réconciliation fut souvent considérée comme un rapprochement spirituel et culturel, les Aborigènes devant pardonner aux blancs les torts commis, alors que les blancs devaient admettre leur responsabilité dans l’oppression et l’éviction des noirs de leurs terres, par le passé. Cependant, vu qu’un traité reconnaissant l’égalité constitutionnelle entre noirs et blancs pourrait entraîner l’exigence de réparations financières, il est peu probable qu’à l’avenir un gouvernement fédéral sauterait le pas.En attendant, dans quelle mesure les avancées concrètes annoncées, comme par exemple les efforts consentis dans les domaines de la santé, de l’instruction et de l’intégration économique—notamment sur le marché de l’emploi—seraient-elles compatibles avec la défense du droit foncier et des pratiques traditionnelles des Aborigènes ? Nous traiterons des convergences et des contradictions entre les perceptions, chez les blancs et les noirs, de l’inégalité socio-économique qui frappe ces derniers. Les progrès matériels réalisés concourent-ils à une évolution significative vers la réconciliation, ou, au contraire, seraient-ils en train d’entraver le processus ?
A new and inexpensive non-bit-for-bit solution reproducibility test based on time step convergence (TSC1.0)
Authors: Wan Hui , Zhang Kai , Rasch Philip J. , Singh Balwinder , Chen Xingyuan , Edwards Jim 
Published: February 2017

Abstract. A test procedure is proposed for identifying numerically significant solution changes in evolution equations used in atmospheric models. The test issues a fail signal when any code modifications or computing environment changes lead to solution differences that exceed the known time step sensitivity of the reference model. Initial evidence is provided using the Community Atmosphere Model (CAM) version 5.3 that the proposed procedure can be used to distinguish rounding-level solution changes from impacts of compiler optimization or parameter perturbation, which are known to cause substantial differences in the simulated climate. The test is not exhaustive since it does not detect issues associated with diagnostic calculations that do not feedback to the model state variables. Nevertheless, it provides a practical and objective way to assess the significance of solution changes. The short simulation length implies low computational cost. The independence between ensemble members allows for parallel execution of all simulations, thus facilitating fast turnaround. The new method is simple to implement since it does not require any code modifications. We expect that the same methodology can be used for any geophysical model to which the concept of time step convergence is applicable.
Incidencia de la distribución del tiempo no lectivo de los docentes en Educación Primaria en el aprendizaje de sus estudiantes
Authors: Martínez-Garrido Cynthia , Murillo F. Javier 
Published: February 2017

Pretendemos determinar la incidencia del tiempo que los docentes iberoamericanos de Educación Primaria destinan a diferentes tareas no lectivas sobre el logro académico de sus estudiantes en Matemáticas y en Lectura. Para ello se ha realizado un estudio con 256 docentes de 9 países de Iberoamérica y sus 5.610 estudiantes. Se ha recogido información de la distribución del tiempo de los docentes, así como de las características de los estudiantes y su entorno, y de su rendimiento en Matemáticas y en Lectura, mediante pruebas previamente validadas para todos los países, al principio y al final del curso. Utilizando Modelos Multinivel de cuatro niveles de análisis (estudiante, aula, escuela y país), encontramos que una mayor dedicación a tres tareas mejora significativamente el logro de los estudiantes: la preparación de las clases, la corrección de evaluaciones y el trabajo con familias. Y, por el contrario, una mayor dedicación a tareas administrativas hace que disminuya el logro de los estudiantes. Con estos resultados se aportan evidencias empíricas acerca de la necesidad de que los docentes tengan unas condiciones laborales adecuadas para desempeñar adecuadamente su trabajo. Así, es necesario considerar que el trabajo de los docentes no es solo estar frente al grupo, también hay que dejarles tiempo y espacios apropiados para que prepararen su trabajo en el aula. Igualmente, todo lo que sea minimizar las tareas administrativas a realizar por los docentes redundará en un mayor aprendizaje de los estudiantes, seguramente porque los docentes se dedicarán “a lo importante”.
Betaproteobacteria
Authors: Boden Rich 
Published: September 2024

Abstract

Be.ta.pro.te.o.bac.te'ri.a. Gr. neut. n.
bêta
, name of the second letter of Greek alphabet (indeclinable); Gr. masc. n.
Prōteus
, Greek god of the sea, capable of assuming many different shapes; N.L. masc. n.
bacter
, a rod, L. neut. pl. n. suff. ‐ia, ending to denote a class; N.L. neut. pl. n.
Betaproteobacteria
, class of bacteria included in the phylum
Proteobacteria
and having 16S rRNA gene sequences related to those of the members of the order
Spirillales
.

Pseudomonadota / Betaproteobacteria

Cells are morphologically diverse—rods, curved rods, spirillae, rings, cocci, reniform rods, stalked rods, multicellular “tablets,” palisades (“ribbons”), or filaments all occur in this class. Cells range from atrichous to monotrichous, amphitrichous or lophotrichous, with “degenerate flagella” in some families. Gliding motility is found in the
Neisseriales
. Gram‐stain‐negative. Endospores, exospores, and cysts are not produced. Metabolism is extremely variable from fermentation to diverse respiration (molecular oxygen, nitrate, nitrite, nitrous oxide, elementary sulfur, Fe(III), Mn(IV), selenite and/or (per)chlorate are used across the class). Growth ranges from heterotrophic to obligately autotrophic, facultatively autotrophic, or potentially obligately mixotrophic (
sensu
heterotrophy and autotrophy occurring simultaneously). Autotrophic taxa are mostly chemolithoautotrophic at the expense of Fe(II), ammonium, nitrite, molecular hydrogen, or reduced sulfur species, with photoautotrophy observed in some
Rhodocyclales
. Carbon and energy sources for heterotrophic growth include complex media, amino acids, intermediates of Krebs' cycle, aromatics, sugars, sterols, fatty acids, C
1
compounds, alcohols, and amino acids. Most taxa are mesophiles with optimal growth <50°C. Most genera are cytochrome
c
oxidase‐positive, but catalase activity is variable. The major respiratory quinone is ubiquinone‐8 (UQ‐8), though some taxa use menaquinone‐8 (MK‐8) or rhodoquinone‐8 (RQ‐8). Dominant fatty acids are C
16:0
, C
16:1
, and C
18:0
, with some variation across orders. The class accommodates the orders
Burkholderiales
,
Neisseriales
,
Spirillales
, and
Rhodocyclales
.

DNA G + C content (mol%)
: 36.0–72.6 (genomic DNA).

Type genus
:
Burkholderia
Yabuuchi et al. 1993, VL45 emend. Gillis et al. 1995, Sawana et al. 2014, Dobritsa and Samadpour 2019.
Aureitalea
Authors: Yokota Akira 
Published: September 2024

Abstract

Au.re.i.ta'le.a. L. masc. adj.
aureus
, golden; L. fem. n.
talea
, a rod; N.L. fem. n.
Aureitalea
, golden rod.

Bacteroidetes / Flavobacteria / Flavobacteriales / Flavobacteriaceae / Aureitalea

The genus
Aureitalea
that accommodates an irregular rod‐shaped, nongliding, and yellow‐pigmented bacterium was isolated from seawater from the western North Pacific Ocean near Japan. The strain, designated S1‐66
T
, is Gram‐stain‐negative, obligately aerobic, heterotrophic, and oxidase‐positive. Growth occurs in the presence of 1–4% NaCl, with optimum growth at 2% NaCl. The strain grows at 15–30°C, with optimum growth at 20–25°C. The predominant isoprenoid quinone is MK‐6, and the major cellular fatty acids are iso‐C
15:0
(26.4%), iso‐C
15:1
(20.3%), and iso‐C
17:0
3‐OH (14.2%). Phylogenetic trees generated using 16S rRNA gene sequences revealed that strain S1‐66
T
belongs to the family
Flavobacteriaceae
and showed 94.2% sequence similarity to the most closely related type strain,
Ulvibacter antarcticus
IMCC3101
T
. On the basis of phenotypic and phylogenetic features, S1‐66
T
is classified in a novel genus and species within the family
Flavobacteriaceae
.

DNA G + C content (mol%)
: 48.1 (HPLC).

Type species
:

Aureitalea marina

Park et al. 2012
VP
.
Ultrafast Tailoring Amorphous Zn0.25V2O5 with Precision‐Engineered Artificial Atomic‐Layer 1T′‐MoS2 Cathode Electrolyte Interphase for Advanced Aqueous Zinc‐Ion Batteries
Authors: Hu Chen , Li Binjie , Nie Kunkun , Wang Ziyi , Zhang Yujia , Yi Lixin , Hao Xiaorong , Zhang Huang , Chong Shaokun , Liu Zhengqing , Huang Wei 
Published: September 2024

AbstractVanadium (V)‐based oxides as cathode materials for aqueous zinc‐ion batteries (AZIBs) still encounter challenges such as sluggish Zn2+ diffusion kinetics and V‐dissolution, thus leading to severe capacity fading and limited life span. Here, we designed an ultrafast and facile colloidal chemical synthesis strategy based on crystalline Zn0.25V2O5 (c‐ZVO) to successfully prepare a‐ZVO@MoS2 core@shell heterostructures, where atomic‐layer MoS2 uniformly coats on the surface of amorphous a‐ZVO. The tailored amorphous structure of a‐ZVO provides more isotropic pathways and active sites for Zn2+, thus significantly enhancing the Zn2+ diffusion kinetics during charge–discharge processes. Meanwhile, as an efficient artificial cathode electrolyte interphase, the precision‐engineered atomic‐layer MoS2 with semi‐metallic 1T′ phase not only contributes to improved electron transport but also effectively inhibits the V‐dissolution of a‐ZVO. Therefore, the prepared a‐ZVO@MoS2 and conceptually validated a‐V2O5@MoS2 derived from commercial c‐V2O5 exhibit excellent cycling stability at an ultralow current density (0.05 A g−1) while maintaining good rate capability and capacity retention. This research achievement provides a new effective strategy for various amorphous cathode designs for AZIBs with superior performance.
Serum CD5L as potential biomarker of thyroid hormone status during pregnancy
Authors: Asaad Sabrina , Chillon Thilo Samson , Filipowicz Dorota , Wilms Britta , Strenge Frank , Szczepanek‐Parulska Ewelina , Minich Waldemar B. , Meyhöfer Sebastian M. , Marquardt Jens U. , Mittag Jens , Oster Henrik , Ruchala Marek , Schomburg Lutz 
Published: September 2024

AbstractThe thyroid hormone (TH) status is routinely assessed by thyrotropin (TSH) and thyroxine (T4). Both biomarkers are mainly regulated by TH receptor beta, whereas many peripheral organs employ the alpha receptor. Serum cluster of differentiation 5‐like molecule (CD5L) is a liver‐derived protein under control of both TH receptor isoforms. However, clinical data on its relation to TH status are sparse. An additional biomarker of TH status is needed in particular during pregnancy, where the routine biomarkers become dynamically disturbed. This study aimed to determine possible covariates regulating serum CD5L and to test its potential suitability as additional TH biomarker during pregnancy. A sandwich ELISA for serum CD5L was established using newly raised antibodies. Circadian effects and the impact of liver disease on serum CD5L concentrations were assessed. Serum samples from pregnant women with well‐characterized TH and trace element status were analyzed, and CD5L concentrations were correlated with other indicators of TH status including TSH, fT4, fT3, copper, and selenium concentrations. The new quantitative assay for CD5L showed high accuracy. Serum CD5L was stable in dilution and refreezing experiments and did not show strong circadian variance or dependency on liver disease. In serum of pregnant women, CD5L correlated positively to fT3, but not to fT4 or TSH. Significant positive correlations of CD5L were observed with serum levels of the TH‐responsive trace elements selenium and copper. The data support the potential suitability of serum CD5L as an additional marker of TH status, with potential value for pregnancy and thyroid disease.
SLC25A19 drives colorectal cancer progression by regulating p53
Authors: Jiang Jinbo , Li Xuemei , Wang Jiayong , Chen Shaofei , Chen Lingjuan 
Published: September 2024

AbstractBackgroundInvestigating the molecular mechanism of colorectal cancer (CRC), a common lethal malignancies worldwide, is of great clinical significance. Solute carrier family 25 member 19 (SLC25A19) is a member of the solute carrier family that contribute to cellular functions, including tumor biology. Recently, many studies have attention on uncovering the relationship of SLC25A19 with malignant cancers, but its precise involvement in the regulation of CRC has not been thoroughly understood. This study sought to uncover the role and mechanism of SLC25A19 in CRC development.MethodsThe GEPIA database and immunohistochemical staining were utilized to detect the expression of SLC25A19 in CRC tissues. The functional influences of SLC25A19 on CRC cell phenotypes were evaluated through a series of assays including celigo cell count, colony formation, CCK‐8, flow cytometry, wound healing, and transwell assays following knocking down SLC25A19. Subsequently, the xenograft tumor model was constructed to evaluate the effect of SLC25A19 on tumor growth in vivo. The underlying mechanisms of SLC25A19 silencing were investigated using the human phospho‐kinase array.ResultsThis study demonstrated the upregulation of SLC25A19 in CRC and its significant correlation with unfavorable prognosis in CRC patients. Suppression of SLC25A19 resulted in significant inhibition of cell proliferation, colony formation, and cell migration, alongside a boost in cell apoptosis. In vivo experiments revealed that silenced SLC25A19 displayed reduced growth rates and formed smaller xenografts. Mechanistically, the p53 pathway was found to be upregulated by SLC25A19 knockdown and mediated the function of SLC25A19.ConclusionsConsequently, SLC25A19 was identified as a novel molecule with key regulatory ability in CRC development.