bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new strategy for calculating the risk of ovarian malignancy algorithm (ROMA)
Authors: Jeong Tae-Dong , Cho Eun-Jung , Ko Dae-Hyun , Lee Woochang , Chun Sail , Kwon Hi Jeong , Hong Ki-Sook , Kim Yong-Man , Min Won-Ki 
Published: January 2017

AbstractBackground:Reliable quantitative measurements of HE4 and CA125 levels are required to calculate the risk of ovarian malignancy algorithm (ROMA) value. We suggest a new reporting strategy for interpreting ROMA values based on analytical measurement range (AMR) and qualified-intervals of the HE4 and CA125 results.Methods:HE4 and CA125 assays from Abbott and Roche were used. The AMRs and the qualified-intervals were as follows: Architect HE4 assay, 20–1500 and 17.2–2637.8 pmol/L; Architect CA125 II assay, 1–1000 and 3.9–14,163.0 U/mL; Elecsys HE4 assay, 15–1500 and 28.8–3847 pmol/L; Elecsys CA125 II assay, 0.6–5000 and 6.5–5000 U/mL. These values were used to simulate the ROMA values.Results:Reporting algorithm for the ROMA value could be classified into three categories. (1) If quantitative HE4 and CA125 levels are reliable, the numerical ROMA value can be reported. (2) If HE4 value is <20 and <28.8 for Abbott and Roche in premenopausal woman, the ROMA value should be reported as “low risk” regardless of the CA125 result. In postmenopausal woman, however, it should be reported as “low risk” (CA125<203.0 and <165.8 for Abbott and Roche) or “undetermined” (vice-versa value). (3) If CA125 value is <3.9 and <6.5 for Abbott and Roche, it should be reported as “low risk” (premenopausal HE4<51.5 and <62.2, postmenopausal HE4<323.0 and <281.5 for Abbott and Roche) or “undetermined” (vice-versa value).Conclusions:New reporting strategy will provide more informative reporting of ROMA values in clinical practice.
Integrating weather and geotechnical monitoring data for assessing the stability of large scale surface mining operations
Authors: Steiakakis Chrysanthos , Agioutantis Zacharias , Apostolou Evangelia , Papavgeri Georgia , Tripolitsiotis Achilles 
Published: January 2017

AbstractThe geotechnical challenges for safe slope design in large scale surface mining operations are enormous. Sometimes one degree of slope inclination can significantly reduce the overburden to ore ratio and therefore dramatically improve the economics of the operation, while large scale slope failures may have a significant impact on human lives. Furthermore, adverse weather conditions, such as high precipitation rates, may unfavorably affect the already delicate balance between operations and safety. Geotechnical, weather and production parameters should be systematically monitored and evaluated in order to safely operate such pits. Appropriate data management, processing and storage are critical to ensure timely and informed decisions.This paper presents an integrated data management system which was developed over a number of years as well as the advantages through a specific application. The presented case study illustrates how the high production slopes of a mine that exceed depths of 100–120 m were successfully mined with an average displacement rate of 10– 20 mm/day, approaching an almost slow to moderate landslide velocity. Monitoring data of the past four years are included in the database and can be analyzed to produce valuable results. Time-series data correlations of movements, precipitation records, etc. are evaluated and presented in this case study. The results can be used to successfully manage mine operations and ensure the safety of the mine and the workforce.
Oxidative polymerization of waste cooking oil with air under hydrodynamic cavitation
Authors: Rinaldi Laura , Wu Zhilin , Giovando Samuele , Bracco Marco , Crudo Daniele , Bosco Valentina , Cravotto Giancarlo 
Published: January 2017

AbstractApart from being a component of some animal feed products, the main industrial use of recycled waste frying oils is biodiesel preparation. With the aim of finding a suitable technology for a cost-effective valorization of used cooking oil, we investigated some oxidative treatments under hydrodynamic cavitation with air flow. This process enabled the preparation of a useful precursor of fatliquor used in the leather industry through the efficient oxidation/polymerization of waste oils at 90°C. The same technique enabled a stable dispersion/emulsification in water without surfactants. Thanks to the use of these innovative techniques, a four-fold reduction of the oxidation time of waste oil was achieved. All the results indicate that the use of a highly efficient rotor-stator generator of hydrodynamic cavitation is compatible with a process scaling up for potential industrial applications.
Crystal structure of 1,1-dimethyl-3-(4-methoxyphenyl)urea, C10H14N2O2
Authors: El-Hiti Gamal A. , Smith Keith , Alshammari Mohammed B. , Hegazy Amany S. , Kariuki Benson M. 
Published: January 2017

Abstract
C10H14N2O2, monoclinic, P21/c (no. 14), a = 14.9185(12) Å, b = 7.7243(6) Å, c = 9.2229(5) Å, β = 91.032(6)°, V = 1062.63(13) Å3, Z = 4, T = 293(2) K.
Biological bases of human musicality
Authors: Perrone-Capano Carla , Volpicelli Floriana , di Porzio Umberto 
Published: January 2017

AbstractMusic is a universal language, present in all human societies. It pervades the lives of most human beings and can recall memories and feelings of the past, can exert positive effects on our mood, can be strongly evocative and ignite intense emotions, and can establish or strengthen social bonds. In this review, we summarize the research and recent progress on the origins and neural substrates of human musicality as well as the changes in brain plasticity elicited by listening or performing music. Indeed, music improves performance in a number of cognitive tasks and may have beneficial effects on diseased brains. The emerging picture begins to unravel how and why particular brain circuits are affected by music. Numerous studies show that music affects emotions and mood, as it is strongly associated with the brain’s reward system. We can therefore assume that an in-depth study of the relationship between music and the brain may help to shed light on how the mind works and how the emotions arise and may improve the methods of music-based rehabilitation for people with neurological disorders. However, many facets of the mind-music connection still remain to be explored and enlightened.
Paving the Way for Better Telecom Performance: Evidence from the Telecommunication Sector in MENA Countries
Authors: EZZAT Riham Ahmed 
Published: January 2017

AbstractSince the 1980s, developing countries started to adopt telecom reforms due to pressures from international institutions. However, Middle East and North African (MENA) countries lagged in adopting such reforms. Even after introducing telecom reforms in MENA region beginning in 1995, not all countries became better off in terms of various performance indicators. Therefore, this paper empirically assesses the effects of regulation, privatization and liberalization reforms, as well as their simultaneous presences, on the sector performance in the telecommunication sector using a sample of 17 MENA countries for the period 1995–2010. We assume that different reforms are affected by institutional, political and economic determinants with respect to the level of democracy, the legal origin, the natural resources rents per country and the year of independence from colonization. We use IV-2SLS (Instrumental Variable Two-Stage Least Squares) estimation to analyze the effect of different reforms on telecom performance in terms of access, productivity and affordability in the fixed and the mobile sector. We find that privatization of the main incumbent operator and fixed-line market liberalization affect the sector performance negatively in terms of fixed access and affordability. Moreover, we find that the simultaneous presence of an independent regulator and a privatized incumbent helps to eliminate drawbacks on the sector performance resulting from privatization. However, the simultaneous presences of the other reforms in terms of regulation-competition and privatization-fixed competition do not help to improve the sector performance.
A novel immobilization matrix for the biosensing of phenol: self assembled monolayers of calixarenes
Authors: Tasci Filiz , Sayin Serkan , Seleci Didem Ag , Demir Bilal , Azak Hacer , Yildiz Huseyin Bekir , Demirkol Dilek Odaci , Timur Suna 
Published: January 2017

Abstract

Aim
The development of calixarene based phenol biosensor.

Methods
This study describes the application of a calixarene derivative, 5,17-diamino-25,27-bis(3-thiol-1-oxypropane)-26,28-dihydroxycalix[4]arene (HS-Calix-NH2) which has both amino and thiol functionalities, in the practical surface modifications for biomolecule binding. The structure of HS-Calix-NH2 allows easy interaction with Au surface and one-step biomolecule immobilization. Self-assembled monolayers (SAMs) of p-amino-functionalized mercaptoalkylcalixarene (HS-Calix-NH2) were formed onto the Au electrode. Then, Laccase (Lac) enzyme was immobilized onto the modified surface by crosslinking with glutaraldehyde (GA). Resulted electrode (HS-Calix-NH2/Lac) was used for the electrochemical analysis of phenolic compounds at −50 mV.

Results
The linearity was observed in the range of 0.1–100 μM and 1.0–100 μM for catechol and phenol, respectively. The potential use of the biosensor was investigated for phenol analysis in artificial samples which simulate the industrial waste water, which is highly acidic and composed of concentrated salt, without needing any sample pre-treatment step.

Conclusion
The prepared Lac biosensor has a potential for rapid, selective and easy detection of phenolic contaminations in samples.
Robust background normalization method for one-channel microarrays
Authors: Akal Tülay , Purutçuoğlu Vilda , Weber Gerhard-Wilhelm 
Published: January 2017

AbstractBackgroundMicroarray technology, aims to measure the amount of changes in transcripted messages for each gene by RNA via quantifying the colour intensity on the arrays. But due to the different experimental conditions, these measurements can include both systematic and random erroneous signals. For this reason, we present a novel gene expression index, called multi-RGX (Multiple-probe Robust Gene Expression Index) for one-channel microarrays.MethodsMulti-RGX, different from other gene expression indices, considers the long-tailed symmetric (LTS) density, covering a wider range of distributions for modelling gene expressions on the log-scale, resulting in robust inference and it takes into account both probe and gene specific intensities. Furthermore, we derive the covariance-variance matrix of model parameters from the observed Fisher information matrix and test the performance of the multi-RGX method in three different datasets.ResultsOur method is found to be a promising method regarding its alternatives in terms of accuracy and computational time.ConclusionMulti-RGX gives accurate results with respect to its alternatives, with a reduction in computational cost.
Evaluating the spermicidal activity of an antimicrobial peptide from the Bufo kavirensis, MaximinBk: in vitro study
Authors: Zare-Zardini Hadi , Fesahat Farzaneh , Halvaei Iman , Nabi Ali , Zare-Shehneh Masoud , Shamsi Farimah , Ebrahimi Leila 
Published: January 2017

Abstract

Objective
The aim of this study was to evaluate the spermicidal activity of this peptide to introduce a new potent agent for prevention of sexually transmitted infections and unplanned pregnancies.

Methods
The purified MaximinBk (with amino acid sequence: ILGPVLGLVGRLAGGLIKRE) was diluted with Ham’s F10 solution in 100, 200, 400, 600, 800 and 900 μg/mL. One milliliter from peptide solution with different dosage was mixed with 200 μL prepared sperm solution in microtube. Sperm motility, viability and morphology were assessed at different time intervals (0.3, 5, 10, 15 min). Eosin–Nigrosin staining and Giemsa staining methods were applied for sperm viability and morphology detection, respectively.

Results
Total spermicidal activity was shown after addition of 900 μg/mL for 0.3 min without any morphological change in the sperm head, midpiece or tail. Also, Eosin–Nigrosin staining indicated MaximinBk can disturb membrane integrity of normal sperm that is in dose-dependent manner.

Conclusion
MaximinBk has spermicidal activity in addition to antimicrobial activities (especially on vaginal infections such as candidal vulvovaginitis). It seems this peptide might be a potential candidate in order to use in male contraception, although, this preliminary study needs more studies to elucidate final conclusion.
Trigonal dodecahedral sodium coordination in a trinuclear copper(II)-sodium complex incorporating a salen-type compartmental Schiff base
Authors: Nandy Madhusudan , Saha Debnath , Rizzoli Corrado , Shit Shyamapada 
Published: January 2017

Abstract
A new trinuclear heterometallic complex, [(CuL)Na(CuL)]·ClO4 (1), has been prepared using a Schiff base, H2L (where H2L=N,N′-(1,2-phenylene)-bis(3-methoxysalicylideneimine) and characterized by elemental analysis, Fourier transform infra-red (FT-IR) spectroscopy, UV/Vis, magnetic, electrochemical, and single crystal X-ray diffraction methods. The structure analysis reveals that two metallo-ligand [(CuL)] units are connected to each other by a sodium ion resulting in the cationic unit [(CuL)Na(CuL)]+. Both the copper(II) ions display an almost square planar geometry while the sodium ion adopts a trigonal-dodecahedral coordination geometry. The spectroscopic and other physicochemical studies are in good agreement with the crystal structure of the complex.
Synthesis, crystal structure and Raman spectrum of Ba7[BO3]3Br(O1.33F1.33)
Authors: Reckeweg Olaf , Schulz Armin , DiSalvo Francis J. 
Published: January 2017

Abstract
In addition to amorphous material and Ba7[BO3]4−x
F2−3x
, air and moisture sensitive single crystals of Ba7[BO3]3Br(O1.33F1.33) were formed from H3BO3, Ba(OH)2, BaF2 and BaBr2·2 H2O in alumina crucibles open to the atmosphere at 1300 K for 13 h. Ba7[BO3]3Br(O1.33F1.33) crystallizes in the hexagonal space group P63
mc (no. 186, Z=2) with the lattice parameters a=1118.1(2) and c=723.93(13) pm. The Raman spectrum of the title compounds was also acquired and is compared to literature data.
Mutants forDrosophilaIsocitrate Dehydrogenase 3b Are Defective in Mitochondrial Function and Larval Cell Death
Authors: Duncan Dianne M , Kiefel Paula , Duncan Ian 
Published: January 2017

AbstractThe death of larval salivary gland cells during metamorphosis in Drosophila melanogaster has been a key system for studying steroid controlled programmed cell death. This death is induced by a pulse of the steroid hormone ecdysone that takes place at the end of the prepupal period. For many years, it has been thought that the ecdysone direct response gene Eip93F (E93) plays a critical role in initiating salivary gland cell death. This conclusion was based largely on the finding that the three “type” alleles of E93 cause a near-complete block in salivary gland cell death. Here, we show that these three mutations are in fact allelic to Idh3b, a nearby gene that encodes the β subunit of isocitrate dehydrogenase 3, a mitochondrial enzyme of the tricarboxylic acid (TCA) cycle. The strongest of the Idh3b alleles appears to cause a near-complete block in oxidative phosphorylation, as mitochondria are depolarized in mutant larvae, and development arrests early during cleavage in embryos from homozygous-mutant germline mothers. Idh3b-mutant larval salivary gland cells fail to undergo mitochondrial fragmentation, which normally precedes the death of these cells, and do not initiate autophagy, an early step in the cell death program. These observations suggest a close relationship between the TCA cycle and the initiation of larval cell death. In normal development, tagged Idh3b is released from salivary gland mitochondria during their fragmentation, suggesting that Idh3b may be an apoptogenic factor that functions much like released cytochrome c in mammalian cells.
Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia.
Authors: Trujillo Angela Maria , Linares Ballesteros Adriana , Sarmiento Isabel Cristina 
Published: January 2017

Background: Acute lymphoblastic leukemia is the most common cancer in children. In developed countries, overall survival rates are around 80%, while in developing countries, survival rate is much lower due to high rates of relapse, and abandonment and complications arising from the disease treatment.Objectives: To assess induction mortality, relapse and treatment abandonment. To describe the most frequent side effects of chemotherapy. To evaluate survival rates of patients and compare the findings found in this study with the existing literature.Material and methods: A retrospective cohort study was conducted on patients aged 1 to 18 with acute lymphoblastic leukemia, who received treatment under the BFM ALL IC 2009 protocol at Fundación Hospital La Misericordia (HOMI), from November 2012 to December 2014.Results: 119 patients were included. Death occurred in two cases during induction (1.67%) and in nine (7.7%) due to treatment, all of them caused by infection/sepsis and in complete remission. Six patients abandoned treatment (5%), while seven relapses occurred (5.9%). All patients experienced some type of side effect related to chemotherapy, the most frequent being febrile neutropenia (41.2%) and grade 3-4 infections (15.8%). Overall survival and event-free survival rates were 79.9% and 73.3%, respectively.Conclusions: Evaluating complications of treatment and death allows adopting measures and strategies to reduce such complications.
Surgical management of pancreatic ascites
Authors: Varma Gunturi Surya Ramachandra , Suman Konidala M.V.S. , G. Sambi Reddy , Narayana Rao Dama V.L. , B. Prabhakar , G.L.N Malleshwara Rao 
Published: January 2017

Background: Pancreatic ascites is a challenging problem faced by clinicians. The management requires a multidisciplinary approach. Timely surgical intervention is the key especially in patients with chronic pancreatitis and pancreatic ascites where conservative and endoscopic treatments were not successful.Methods: The data was retrieved from a prospectively maintained database for a period of 4 years. A total of 14 patients were included. They were initially optimized with ascitic fluid drainage, nutritional supplementation either enteral or parenteral. Endoscopic retrograde cholangio pancreatography (ERCP) was done in patients with failed conservative treatment after 2 weeks. Endoscopic pancreatic stenting was attempted in proximal ductal disruptions. Nonresponders were taken up for surgery. The type of surgery was based on the site of leak and associated pancreatic pathology like pseudocyst.Results: Initially three patients were responded to conservative management. ERCP was done in 9/14 patients. ERCP demonstrated leak of contrast into peritoneal cavity in 3 (3/9), leaking pancreatic pseudocyst in 3 (3/9) and non-visualisation of distal duct in 2 (2/9). ERCP and stenting of pancreatic duct was attempted in three patients and was successful in resolution of symptoms in one. Nine out of fourteen needed surgical intervention. Surgery was based on site of leak and presence of pseudocyst.Conclusions: Majority of the patients in our study were ethanolics and a change in life style early in the course can prevent this morbid disease. Nasojejunal tube feeding with blendarized home feeds will improve the nutritional status. CECT abdomen and ERCP will give a road map in deciding the type of intervention. For proximal ductal disruption endoscopic stenting should be tried before going for a major surgical intervention. Surgery provides definitive cure.
Study of nutritional status, comorbidities and other risk factors associated with dengue fever: data from a tertiary hospital in North India
Authors: Kaur Harharpreet , Kaur Harpreet , Kaur Navjot , Kaur Kawalinder 
Published: January 2017

Background: Dengue is a major health problem in India. The understanding of the factors which predispose to the infection and which are involved in its progression is fundamental for improved clinical outcomes. This study was initiated with the aim of identifying the patient population at risk and comorbidities involved in the development of complications.Methods: This was an observational and case control study in which 130 cases and controls taken from the healthy population were evaluated with respect to data regarding demographics, complications and co morbid metabolic diseases.Results: There was a predominance of males in cases as compared to controls especially between ages of 21-30 years . There was a significantly higher rate of comorbidities in cases as compared to controls and constituted 62.3% of the total cases. Obese /overweight cases were 60.8 %, fatty liver -30.76%, diabetics- 15.4 %, hypertensives 15.4%, cases of hypothyroidism 2.3 %, renal diseases 5.38% and ischemic heart disease 6.92%, 18.50% cases developed complications and severe disease (SD). There was a significant association of pleural effusion/ascites and gall bladder edema with SD. Association of comorbidities with SD was however not significant. Such cases tended to develop complications like heart failure, angina, renal failure and multiorgan failure and were difficult to treat. 5 (3.84%) patients died. 4 had associated comorbidities.Conclusions: Comorbidities like obesity predispose to dengue infection and are liable to cause serious complications knowledge of which can prompt early clinical intervention and reduction of mortality.
TIPOLOGI MAJELIS TAKLIM DI KOTA BOGOR TIMUR
Authors: Masfiah Umi 
Published: January 2017

<p>There are 487 majelis taklim at Bogar City and 102 at East <br />Bogar sub district. These figures represent trend in the Bogar<br />community, especially in East Bogar sub district, to actualize their<br />religious life. <br />Popularity of majelis ta/dim phenomenon is not an un-historic<br />process; it is a continuous and compound process. Social<br />improvements occurred in Bogar City community, especially in East<br />Bogar, because of development processes, have vary religious life,<br />both in activities media and in understanding urgent Islamic<br />concepts. Three objects referred to observe comprehension and<br />variety in the community in this research are polygamy, allotment of<br />inheritance, and hajj. Those objects are related to the popularity<br />of majelis taklim phenomenon, in the village, in the real estate<br />complex or even in the governmental institutes. <br />Based on observation of majelis taklim phenomenon at<br />East Bogar sub district, there are two conclusions, namely:</p><p><br />1. There are two factors which cause the popularity of majelis<br />taklimat East Bogar sub district, namely ustadz s orientation and<br />majelis taklim community s orientation .. Ustadz s orientation is<br />related to transfer of knowledge which ustadz has. Each santri<br />who just come home from Islamic boarding house or just passed<br />from Islamic higher education tend to form majelis taklim or become<br />ustadz of a majelis taklim. Community s orientation is related to no<br />activities factors, self-actualization, and social interaction although<br />motivation toget better religious understanding is a dominant factor.</p><p><br />2. Typology of understanding religious objects related to<br />polygamy.inheritance law, and hajj is divided into 2 (two) aspects:</p><p>a.In ustadz community, there are two trends</p><p>1). Understanding polygamy, inheritance law and hajj <br />by rientation to texts as religious reference </p><p>2). Understanding polygamy, inheritance law and hajj<br />by Orientation to texts as religious medium. <br />b. Typology of community understanding of religious objects<br />elated to polygamy, inheritance law and hajj is also divided into<br />two trends as their ustadz s typology. It is also influenced by status<br />and economic factors.</p>