bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accounting for biodiversity in Australia
Authors: Hossain Md Moazzem 
Published: January 2017

PurposeThis paper aims to respond to recent calls by Jones (2014) and Jones and Solomon (Accounting, Auditing & Accountability Journal, 2013) for more studies on biodiversity accounting and reporting. In particular, this paper explores biodiversity reporting of the Murray-Darling Basin Authority (MDBA), an Australian public sector enterprise.Design/methodology/approachThe paper uses content analysis of MDBA’s published annual reports over the period of 15 years (1998-2012). Archival data (from different government departments) are also used to prepare natural inventory model.FindingsThe paper finds that although specific species, such as flora and fauna, and habitats-related disclosures have increased over the time, such information still allows only a partial construction of an inventory of natural assets, using Jones’ (1996, 2003) model. However, unlike prior studies that find lack of data availability to be the main impediment for operationalising biodiversity accounting, the abundance of biodiversity data in Australia makes it comparatively easier to produce such a statement.Research limitations/implicationsInformed by the environmental stewardship framework, the results of this paper suggest that the disclosures made by MDBA are constrained potentially due to its use of traditional accounting mechanisms of reporting that only allow tradable items to be reported to stakeholders. An alternative reporting format would be more relevant to stakeholder groups who are more interested in information regarding quality and availability of water, and loss of biodiversity in the basin area rather than the financial performance of the MDBA.Originality/valueAlthough there are a growing number of studies exploring biodiversity reporting in Australia, this paper is one of the earlier attempts to operationalise biodiversity (particularly habitats, flora and fauna) within the context of an Australian public sector enterprise.
Asset-liability management in Islamic banks: evidence from emerging markets
Authors: Abou-El-Sood Heba , El-Ansary Osama 
Published: January 2017

Purpose
Motivated by massive bank failures during the financial crisis and the remarkable resilience of Islamic banks (IBs), this paper aims to analyze the interdependencies between asset/liability portfolio choices of IBs in emerging markets.

Design/methodology/approach
The authors collect data from the financial statements of IBs in the Middle East and North Africa region and Southeast Asia during the period 2002-2012. Using canonical correlation analysis, the authors investigate the degree of interdependencies between the asset/liability accounts unique to IBs and how their ALM models work at times of economic turmoil.

Findings
IBs tend to make decisions on sources of finance based on their asset portfolio choices. The interdependencies are stronger for small banks. IBs direct more of their investments to risk-mitigating instruments that share the risk with the borrower/client and are based on the purchase and sale of real goods rather than financial instruments. Additionally, banks tend to rely less on equity to finance their investments during economic boom and increase their equity holdings during economic bust.

Practical implications
This paper contributes to research on an under-researched, globally growing finance sector. It extends research on ALM while providing novel evidence using non-standardized asset/liability accounts unique to IBs.

Originality/value
The analysis of unique accounts has not been discussed in prior studies, which mainly used standardized account balances to compare Islamic and conventional banks. Moreover, the resilience of IBs and whether their ALM models are superior at times of turmoil has remained a black box. The results of this study are relevant to unravel this unanswered question.
Basal Vacuolization in Renal Tubular Epithelial Cells at Autopsy and Their Relation to Ketoacidosis
Authors: Zhou Chong , Yool Andrea J. , Byard Roger W. 
Published: January 2017

AbstractBasal vacuolization of renal tubular epithelial cells is a useful postmortem marker for ketoacidosis. To investigate its incidence and relationship to the severity of ketoacidosis, 158 autopsy cases with elevated β‐hydroxybutyrate (>1 mmol/L) over a 7‐year‐period were retrospectively reviewed. Sixty‐eight cases (43%) exhibited basal vacuolizations (vitreous β‐hydroxybutyrate: 1.16–29.35 mmol/L, mean 10.28 mmol/L), and 90 cases (57%) did not (vitreous β‐hydroxybutyrate: 1.03–13.7 mmol/L, mean 2.84 mmol/L). Quantitative analysis revealed on average a fourfold elevation in β‐hydroxybutyrate in cases with basal vacuolizations compared to those without; 10.3% of cases with β‐hydroxybutyrate concentrations between 1.01 and 2.00 mmol/L had basal vacuolizations, and this incidence increased to 33.3% with concentrations between 4.01 and 6.00 mmol/L. A marked increase in incidence to >70% was observed with concentrations >6.00 mmol/L, and basal vacuoles were invariably present (100%) with concentrations >14.01 mmol/L. This study demonstrates that basal vacuolizations are a sensitive marker for significant ketoacidosis and reaffirms its use as an indicator for likely cases of fatal ketoacidosis at autopsy.
The Toxicology of Methadone‐Related Death in Infants Under 1 Year: Three Case Series and Review of the Literature
Authors: Paul Anthea B. Mahesan , Simms Lary , Mahesan Arnold M. 
Published: January 2017

AbstractMethadone‐related fatalities occur rarely in infants under 1 year, with five confirmed cases in the literature. The interpretation of pediatric postmortem toxicology relies on adult data; however, infants have crucial physiological differences that may impact interpretation of results. Retrospective case review included scene investigation, interviews, autopsy, and NIH/CDC Sudden Unexplained Infant Death Investigation Reporting Form. Methadone levels were confirmed by liquid chromatography/tandem mass spectrometry (LC‐MS/MS). The fatal blood methadone levels in this case series ranged from 69 to 700 ng/mL. This review of the literature adds toxicological findings of three methadone‐related infant fatalities and reviews the current literature on methadone‐related death in infants under 1 year. With opioid use on the rise in today's society, forensic experts should have a high index of suspicion for the possibility of intentional or unintentional poisoning in infants.
Influence of the Addition of Minced Fish on the Preparation of Fish Sausage: Effects on Sensory Properties
Authors: Lago Amanda M. T. , Vidal Ana C. C. , Schiassi Maria C. E. V. , Reis Tatiana , Pimenta Carlos , Pimenta Maria E. S. G. 
Published: January 2017

AbstractIn this study, we evaluated the effect of minced fish (MF) inclusion on the acceptance of tilapia sausages. One hundred consumers participated in the sensory acceptance test in relation to the attributes appearance, color, aroma, flavor, texture, overall impression, and purchase intent. The tests were conducted using the same composition of ingredients, varying only the raw material (MF and fillet), resulting in 5 different formulations. To represent the results of the sensory attributes, we generated internal preference maps through principal component analysis and parallel factor analysis, as well as frequency histograms. The data showed greater acceptability for the sample produced with 50% MF, although all had shown satisfactory results. We conclude that inclusion of MF can be suitable in the preparation of fish sausage due to high consumer acceptance.
Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed
Authors: Mao Yingyi , Han Jigang , Tian Fang , Tang Xue , Hu Yonghong , Guan Yan 
Published: January 2017

AbstractEight wild species in Sect. Moutan DC (tree peony) of the genus Paeonia grown in natural habitats and 1 cultivated specie were investigated to analyze their fatty acid and bioactive phenolic compound profiles. For fatty acid composition, P. ludlowii contained the lowest α‐linolenic acid (27.68%) and P. jishanensis contained the highest (51.96 %) content of the 9 species. For phenolic compounds, P. qiui contained the highest resveratrol (2.12 mg/g), P. delavayi contained the highest β‐gentiobiosylpaeoniflorin (26.23 mg/g), and P. ostii contained the highest paeoniflorin (23.66 mg/g). P. ostii was selected to perform a feasibility study because of its relatively high level of α‐linolenic acid 46.53%, low in ω‐6 to ω‐3 ratio of 1:2, and high level of the preferred bioactive phenolic compounds l including paeoniflorin and resveratrol. Physical pressing and refining process were conducted to obtain P. ostii seed oil. It exhibited bland sensory attributes described as slight grassy, very slight nutty, no painty or fishy aroma and slight grassy, slight nutty flavor with a very slight throat catch. Tocol results reported high level in tree peony seed oil 223.5 ± 13.65 mg/100 g with γ‐tocopherol 70.1 ± 2.14 mg/100 g, and γ‐tocotrienol 149.6 ± 15.83 mg/g. Because of the high total tocol, γ‐tocopherol and γ‐tocotrienol levels, and tree peony seed oil exhibited better oxidation stability than flaxseed oil even with similar α‐linolenic acid levels. In addition, high levels of γ‐tocopherol and γ‐tocotrienol can introduce therapeutic effects such as antiinflammation and antioxidation. Therefore, this study showed that tree peony seed oil has a great potential to be used in edible oil, nutraceutical supplement, and other health care products.
Effects of Different Simple Triglycerides on Cell Fatty Acid Compositions, Proliferation‐Related Protein, and Gene Expressions Induced by Oxidized‐LDL in HUVSMCs
Authors: Li Hongyan , Pan Yao , Luo Kaiyun , Luo Ting , Fan Yawei , Deng Zeyuan 
Published: January 2017

AbstractThe proliferating effects of 3 different simple triglycerides (tristearin, triolein, and trilinolein) on the human umbilical vein smooth muscle cells (HUVSMCs) induced by oxidized‐LDL (ox‐LDL) were investigated in this study. The protein and mRNA gene expressions of proliferating cell nuclear antigen (PCNA), smooth muscle‐α‐actin (SM‐α‐actin), and monocyte chemoattractant protein‐1 (MCP‐1) in HUVSMCs were measured by Western blotting and real‐time quantitative polymerase chain reaction (PCR). It was shown that in tristearin (SSS) treated HUVSMCs, the saturated fatty acid content was increased, and the compositions of polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid were decreased significantly. On the other hand, triolein (OOO) and trilinolein (LLL) significantly increased the levels of some typical PUFA such as arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. Moreover, LLL and OOO could upregulate the protein and mRNA expressions of PCNA, MCP‐1 as well as downregulate the expression of SM‐α‐actin. The results also showed that, SSS had significant promotion effects on the proliferation of HUVSMCs induced by ox‐LDL. Although both LLL and OOO could inhibit the proliferation of HUVSMCs induced by ox‐LDL, and might have certain inhibition of the atherosclerotic process.
Managing Risk and Uncertainty in Health Technology Introduction: The Role of Managed Entry Agreements
Authors: Kanavos Panos , Ferrario Alessandra , Tafuri Giovanni , Siviero Paolo 
Published: January 2017

AbstractManaged entry agreements (MEAs) comprise a variety of instruments to reduce uncertainty arising from incomplete information on budget impact, cost‐effectiveness, use in real life, and access to new therapies. MEAs have a number of advantages and limitations and are sometimes faced with scepticism among decision‐makers. Their uptake and use – particularly financial MEAs ‐ has been fast in many European Union Member States and beyond. The use of MEAs highlights their significance as a conduit for satisfying a number of policy imperatives while mitigating risk and the limitations of current approaches to coverage decisions, including health technology assessment (HTA), in securing reasonable prices and addressing uncertainties around therapeutic effect in real life. Despite the large number of agreements implemented, little information is available on their impact. The little amount of available information is hampering cross‐country learning and the ability of patients to engage in the process. Despite their proliferation, MEAs should not become a quick‐fix solution to addressing the risk and uncertainty arising from the introduction of new therapies; instead, they should be integrated into a process of managed introduction of new therapies starting with horizon scanning and forecasting activities, proceeds to HTA assessment and continues with post‐marketing studies and surveillance.
P73 G4C14‐to‐A4T14 polymorphism is associated with survival in advanced non‐small cell lung cancer patients
Authors: Ge Lei , Yang Yang , Sun Yifeng , Xu Wen , Lu Daru , Su Bo 
Published: January 2017

Backgroundp73, a structural and functional homolog of p53, plays an important role in modulating cell cycle arrest. This study investigated the association between p73 G4C14‐to‐A4T14 polymorphism and survival outcomes in a Chinese population of advanced non‐small cell lung cancer (NSCLC) patients treated with platinum agents.MethodsThe p73 G4C14‐to‐A4T14 polymorphism was genotyped using DNA from blood samples of advanced NSCLC patients (642 in the discovery set and 330 in the replication set). The relationship of the p73 G4C14‐to‐A4T14 polymorphism with clinical outcomes was analyzed.ResultsCompared with the GC/GC genotype, the genotypes containing AT allele (GC/AT + AT/AT genotypes) were associated with significantly prolonged overall survival (P = 0.040) in the discovery set and after pooling results from the replication set. Stratification analysis revealed that the association was more pronounced in subjects who were older (P = 0.001), male (P = 0.007), smokers (P = 0.006), had a low Eastern Cooperative Oncology Group performance status (P = 0.001), in tumor node metastasis stage IV (P = 0.008), and with adenocarcinoma (P = 0.002). The objective response rates of patients with GC/AT + AT/AT genotypes were statistically higher than those with the GC/GC genotype (P = 0.047).ConclusionOur findings suggest that the p73 G4C14‐to‐A4T14 polymorphism may be related to survival outcome in advanced NSCLC patients.
Can fear conditioning repel California sea lions from fishing activities?
Authors: Schakner Zachary A. , Götz Thomas , Janik Vincent M. , Blumstein Daniel T. 
Published: January 2017

AbstractMarine mammal interactions with fisheries create conflicts that can threaten human safety, economic interests and marine mammal survival. A deterrent that capitalizes on learning mechanisms, like fear conditioning, may enhance success while simultaneously balancing welfare concerns and reduce noise pollution. During fear conditioning, individuals learn the cues that precede the dangerous stimuli, and respond by avoiding the painful situations. We tested the efficacy of fear conditioning using acoustic stimuli for reducing California sea lion Zalophus californianus interactions from two fishing contexts in California, USA; bait barges and recreational fishing vessels. We performed conditioning trials on 24 individual sea lions interacting with bait barges. We tested for acquisition of conditioned fear by pairing a neutral tone with a startle stimulus. Avoidance was strongest in response to the startle stimulus alone, but low when paired with a neutral tone. From actively fishing vessels, we tested for fear conditioning by exposing sea lions to a neutral tone followed by a startle pulse, a startle pulse alone or a no sound control. We conducted playbacks from 146 (including 48 no sound control) stops over two summer fishing seasons (2013, 2014). The startle stimulus decreased surfacing frequency, reduced bait foraging and increased surfacing distance from the vessel while the conditioned stimulus only caused a mild reduction in surfacing frequency with no other behavioral change. Exposing animals to a pair of a conditioned stimulus with a startle pulse did not achieve the intended management outcome. Rather, it generated evidence (in two study contexts) of immediate learning that led to the reduction of the unconditioned response. Taken together, our results suggest that for fear conditioning to be applied as a non‐lethal deterrent, careful consideration has to be given to individual behavior, the unconditioned/conditioned responses and the overall management goals.
Seahorses (Hippocampus spp.) as a case study for locating cryptic and data‐poor marine fishes for conservation
Authors: Aylesworth L. , Loh T.‐L. , Rongrongmuang W. , Vincent A. C. J. 
Published: January 2017

AbstractWhen seeking to conserve data‐poor species, we need to decide how to allocate research effort, especially when threats are substantial and pressing. Our study provides guidance for sampling marine fishes that are particularly difficult to find – those species that are cryptic or rare and or where little information exists on local distribution (data‐poor). We used our experience searching for seahorses (Hippocampus spp.) in Thailand to evaluate two search strategies for marine conservation: (1) determining relative abundance and (2) searching for presence/absence with detection probabilities. Our fieldwork indicated that using the presence/absence framework was more likely to lead to inferences that seahorses could be found in the site than when using the relative abundance framework. This realization would support a commonsense approach, where presence/absence with detection probabilities is centrally important to marine conservation planning for cryptic and or data‐poor marine species.
Evidence for a role of eosinophils in blister formation in bullous pemphigoid
Authors: de Graauw E. , Sitaru C. , Horn M. , Borradori L. , Yousefi S. , Simon H.‐U. , Simon D. 
Published: January 2017

AbstractBackgroundBullous pemphigoid (BP) is an autoimmune bullous disease of the skin characterized by subepidermal blister formation due to tissue‐bound and circulating autoantibodies to the hemidesmosomal antigens BP180 and BP230. Although eosinophils and their toxic mediators are found abundantly in BP lesions, their role in blister formation has remained unclear.ObjectiveTo investigate the role of eosinophils in the pathogenesis of BP with a specific focus on blister formation and to define conditions inducing dermal–epidermal separation (DES).MethodsIn an ex vivo human model of BP, normal human skin cryosections were incubated with purified human peripheral blood eosinophils with or without activation in the presence or absence of BP autoantibodies, brefeldin A, diphenyleneiodonium, DNase or blocking F(ab′)2 fragments to CD16, CD18, CD32 and CD64. Dermal–epidermal separation was assessed by light microscopy studies and quantified using Fiji software.ResultsFollowing activation with IL‐5 and in the presence of BP autoantibodies, eosinophils induced separation along the dermal–epidermal junction of ex vivo skin. Dermal–epidermal separation was significantly reduced by blocking any of the following: Fcγ receptor binding (P = 0.048), eosinophil adhesion (P = 0.046), reactive oxygen species (ROS) production (P = 0.002), degranulation (P < 0.0001) or eosinophil extracellular trap (EET) formation (P = 0.048).ConclusionsOur results provide evidence that IL‐5‐activated eosinophils directly contribute to BP blister formation in the presence of BP autoantibodies. Dermal–epidermal separation by IL‐5‐activated eosinophils depends on adhesion and Fcγ receptor activation, requires elevated ROS production and degranulation and involves EET formation. Thus, targeting eosinophils may be a promising therapeutic approach for BP.
Contesting the Settler City: Indigenous Self‐Determination, New Urban Reserves, and the Neoliberalization of Colonialism
Authors: Tomiak Julie 
Published: January 2017

AbstractIn settler colonial contexts the historical and ongoing dispossession and displacement of Indigenous peoples is foundational to understanding the production of urban space. What does it mean that cities in what is now known as Canada are Indigenous places and premised on the ongoing dispossession of Indigenous peoples? What roles do new urban reserves play in subverting or reinforcing the colonial‐capitalist sociospatial order? This paper examines these questions in relation to new urban reserves in Canada. Most common in the Prairie provinces, new urban reserves are satellite land holdings of First Nation communities located outside of the city. While the settler state narrowly confines new urban reserves to neoliberal agendas, First Nations are successfully advancing reserve creation to generate economic self‐sufficiency, exercise self‐determination, and subvert settler state boundaries. I argue that new urban reserves are contradictory spaces, as products and vehicles of settler‐colonial state powerandIndigenous resistance and place‐making.
Visual function response to ocriplasmin for the treatment of vitreomacular traction and macular hole
Authors: Jackson Timothy L. , Verstraeten Thomas , Duchateau Luc , Lescrauwaet Benedicte 
Published: January 2017

AbstractPurposeTo assess the effect of an intravitreal ocriplasmin injection on visual function, measured using visual acuity (VA) and vision‐related quality of life.MethodsPost hoc analysis of prespecified secondary end‐points in two multicentre, randomized, double‐masked, phase 3 clinical trials. A total of 652 participants with symptomatic vitreomacular adhesion were enrolled, of whom 464 received a single intravitreal injection of 125 μg ocriplasmin and 188 received a single intravitreal placebo injection. Based on principal components analysis results, visual function response (VFR) was defined as either a VA improvement of ≥2 lines; or an improvement in the composite score of the National Eye Institute Visual Function Questionnaire (VFQ‐25) exceeding the minimal clinically important difference (MCID), estimated using the standard error of measurement approach; or an improvement in the VFQ‐25 driving subscale score exceeding the MCID. The main outcome measure was VFR at 6 months.ResultsA VFR occurred in 55.1% of the ocriplasmin group versus 34.2% of the placebo injection group (p < 0.0001). This comprised 23.7% versus 11.2% (p = 0.0003) with a ≥ 2‐line VA improvement, 35.9% versus 22.7% (p = 0.0016) for the VFQ‐25 composite score, and 10.2% versus 6.2% (p = 0.1697) for the driving subscale.ConclusionOcriplasmin produces a clinically meaningful visual function benefit.