bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
Authors: Quiroz Alonso , Belledonne Gabriela , Saavedra Fujiko , González Javier , Busso Dolores 
Published: October 2024

IntroductionGenetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations characterized by abnormal brain and spine formation. Mouse embryos deficient in Scavenger Receptor Class B Type 1 (SR-B1), which is involved in the bidirectional transfer of lipids between lipoproteins and cells, exhibit a high prevalence of exencephaly, preventable by maternal vitamin E supplementation. SR-B1 knock-out (KO) embryos are severely deficient in vitamin E and show elevated reactive oxygen species levels during neurulation.MethodsWe fed SR-B1 heterozygous female mice a high-fat/high-sugar (HFHS) diet and evaluated the vitamin E and oxidative status in dams and embryos from heterozygous intercrosses. We also determined the incidence of NTD.Results and discussionHFHS-fed SR-B1 HET females exhibited altered glucose metabolism and excess circulating lipids, along with a higher incidence of embryos with developmental delay and NTD. Vitamin E supplementation partially mitigated HFHS-induced maternal metabolic abnormalities and completely prevented embryonic malformations, likely through indirect mechanisms involving the reduction of oxidative stress and improved lipid handling by the parietal yolk sac.
Diagnostic value of effusion adenosine deaminase, γ-interferon release assay and effusion lactatedehy drogenase/effusion adenosine deaminase for tuberculous pleural effusion in patients aged 60 years and above
Authors: Guo Fei , Huimin Chen , Xia Wei , Xu Yilin , Jin Weijiang , Liu Fang 
Published: October 2024

BackgroundChina is experiencing rapid growth in its population of older adults, which may lead to increased susceptibility to tuberculous pleural effusion (TPE) due to age-related changes in the immune system. This study aimed to investigate the diagnostic potential of multiple biomarkers in individuals aged 60 years and above with pleural effusion.MethodsA total of 519 adult patients from Ningbo First Hospital were included in the study, with 7 biomarkers and their ratios in serum and pleural effusion analyzed using logistic regression analysis. Effusion Adenosine Deaminase(ADA), γ-Interferon Release Assay(IGRA), and Effusion lactatedehy drogenase(LDH)/Effusion ADA were identified as valuable parameters for differentiating TPE from non-TPE, particularly in individuals aged 60 years and older.ResultsEffusion ADA, IGRA, and Effusion LDH/Effusion ADA were identified as valuable parameters for the differential diagnosis of TPE from non-TPE, showing good diagnostic performance in individuals aged 60 years and older. The combined diagnosis of these three indexes achieved the highest diagnostic accuracy for TPE in this age group, with an AUC of 0.925, sensitivity of 85.23%, and specificity of 89.57%.ConclusionsOverall, the study highlights the importance of using multiple indicators for a combined diagnosis to improve diagnostic efficacy in detecting tuberculous pleurisy in older individuals as for young patients.
Early diaphragm dysfunction assessed by ultrasonography after cardiac surgery: a retrospective cohort study
Authors: Huai Hongbo , Ge Min , Zhao Zhigang , Xiong Ping , Hong Wenjun , Jiang Zhongli , Wang Jianming 
Published: October 2024

ObjectiveApproximately 10%–70% of patients may develop diaphragmatic dysfunction after cardiac surgery, which may lead to delayed weaning from mechanical ventilation, increased ICU stays, postoperative hospitalization stays, and respiratory complications. However, its impact on prognosis and risk factors remain controversy. Therefore, we conducted a retrospective cohort study in which we evaluated diaphragmatic dysfunction in patients who underwent cardiac surgery via bedside diaphragm ultrasound to investigate its prognosis and possible risk factors.MethodsData from the electronic medical records system included case records and ultrasound images of the diaphragm for 177 consecutive patients admitted to the ICU following cardiac thoracotomy surgeries performed between June and September 2020. Diaphragmatic dysfunction was defined as a diaphragmatic excursion of less than 9 mm in women and less than 10 mm in men at rest, with an average thickening fraction of less than 20%. SPSS 25.0 software was used to analyse the relationships between patients' general information, intraoperative and postoperative factors and diaphragmatic dysfunction, as well as the impact on patients' hospitalization days, mechanical ventilation time and respiratory system complications.ResultsThe incidence of early postoperative diaphragmatic dysfunction after cardiac surgery was 40.7%. Patients with diaphragmatic insufficiency were more likely to sequentially use noninvasive ventilation within 24 h after weaning off mechanical ventilation (3.8% vs. 12.5%, P = 0.029) and to require more oxygen support (23.8% vs. 40.3%, P = 0.019). Although there was no significant difference, the diaphragmatic dysfunction group tended to have longer ICU stays and postoperative hospital stays than did the normal diaphragmatic function group (P = 0.119, P = 0.073). Univariate and multivariate logistic regression analyses both revealed that chest tube drainage placed during surgery accompanied by bloody drainage fluid was an independent risk factor for diaphragmatic dysfunction (univariate analysis: 95% CI: 1.126–4.137, P = 0.021; multivariate analysis: 95% CI: 1.036–3.897, P = 0.039).ConclusionEearly diaphragmatic dysfunction after cardiac surgery increased the proportion of patients who underwent sequential noninvasive ventilation after weaning from mechanical ventilation and who required more oxygen. Chest tube drainage placed during surgery accompanied by bloody drainage fluid was an independent risk factor for diaphragmatic dysfunction, providing evidence-based guidance for respiratory rehabilitation after cardiac surgery.
Cultivating the capacity for active balancing during adolescence: pathways to a coherent self
Authors: Juneja Abhishek , Hansen David M. , Lemon Michael P. 
Published: October 2024

IntroductionIn this paper we propose that one of the core developmental aims of adolescence is to cultivate a capacity for active balancing as the primary process for creating a coherent, agentic self capable of contributing to the functioning and purposes of the communities which adolescents inhabit, including society as a broader community. While there many valuable initiatives and programs to promote positive development, learning, and wellbeing, these efforts typically take a siloed approach focusing on one dimension of development (e.g., social-emotional learning), leaving adolescents to create coherence from these disconnected approaches. As adolescence face an increasingly uncertain future (e.g., career instability), serious threats to human survival (e.g., environmental degradation), social divides (e.g., political and ideological polarization), etc., a siloed approach to adolescent development is not simply outmoded but it reinforces a fragmented self.Conceptual model and backgroundIn this paper we argue that a siloed approach to adolescent development and learning may contribute to a fragmented sense of self and agency, which can be associated with increased vulnerability to mental health challenges. We first link the proposed developmental aim of adolescence to neuroscience findings that identify three brain changes during adolescence that lay the groundwork for cultivating active balancing and provide an ontogenetic neurological push for adolescents to learn and manage how to engage their worlds. Leveraging this ontogenetic push, we propose adolescents can cultivate their capacity for active balancing within the cultural communities of practice they inhabit. These communities provide a ready and powerful fusion of action, affect, and thought into coherent and relevant understandings of the why, how, and utility of practices in a community, or what we label orientations. Active balancing is the process of actively seeking to establish or reestablish one's intended balance among these orientations.Conclusions and implicationsBuilding the capacity for active balancing, we suggest, engenders greater resilience and adaptability to a range of situations, a tolerance for and ability to resolve tensions, and an ability to transcend vast differences, including cultural and ideological. Implications for both the adolescent and society are discussed.
Evaluation of students’ digital literacy through an immersive university-high school collaboration
Authors: Bruckhaus Alexander A. , Bennett Alexis , Brawer-Cohen Maya , Sinclair Michael , Ramirez-De La Cruz Glendy , Ragusa Gisele , Duncan Dominique 
Published: October 2024

IntroductionRecent efforts including the U.S. Department of Education’s Raise the Bar: STEM Excellence for All Students, designed to strengthen Science, Technology, Engineering and Mathematics (STEM) education, typify the development of effective outreach programs implemented in high school settings to increase STEM achievement and literacy and to promote future careers in STEM. Specifically, artificial intelligence (AI) and machine learning (ML) are topics of great importance and interest but are often reserved for higher-level education. Introductions of complex subjects in high school promotes student efficacy, enthusiasm, and skill-development for STEM careers. Establishing strong partnerships between universities and high schools is mutually beneficial for the professional development of students, teachers, and professors. In this paper, we detail immersive outreach efforts and their effectiveness in a high school setting.MethodsFrom Spring 2021 to Spring 2024, we conducted eight data-science and analysis-coding style workshops along with two data science units, with 302 students participating in the data science workshops and 82 students in the data science units. All students who participated in the data science lessons completed a comprehensive final project. Surveys measuring knowledge and appeal to data science and coding were conducted both retrospectively and prospectively, before and after each workshop and the data science units. A 1 year follow up survey was conducted for students in the 2023 data science lessons (n = 23).ResultsOverall, average student interest significantly increased from 2.72 ± 1.08/5.0 (n = 205) to 3.15 ± 1.18/5.0 (n = 181, p = 0.001) during the data science workshops, while 70% of students expressed desire to continue with coding. Interest modestly increased in the data science lessons from 3.15 ± 0.65/4.0 to 3.17 ± 0.77/4.0 (n = 82, p = 0.8571), while knowledge significantly increased from 64.16% to 88.5% (% correct out of six questions) in the 2023 data science lessons and from 52.62% to 60.79% (% correct out of 29 questions) in the 2024 data science lessons.DiscussionIncreasing STEM exposure through outreach programs and a modified curriculum can positively alter students’ career trajectory and prepare them for the evolving technologically advanced world and the careers within it.
The role of socio-emotional security on school engagement and academic achievement: systematic literature review
Authors: Dias Pedro , Veríssimo Lurdes , Carneiro Alexandra , Duarte Raquel 
Published: October 2024

IntroductionSocio-emotional security and particularly secure attachment relationships with parents and peers have been associated with positive developmental outcomes, including school-related variables. This systematic literature review aims to provide a comprehensive analysis of the literature, exploring the relationship between socio-emotional security (attachment, support, and secure relations with parents and peers) and academic achievement, school engagement, and early school dropout.MethodsThe inclusion criteria were studies with socio-emotional security as the independent variable and academic achievement and/or school engagement as the dependent variable, using a quantitative methodology, written in English. The exclusion criteria were articles presenting literature review or meta-analysis, interventions or instrument validation studies, studies with a qualitative approach, studies developed in an e-learning context, studies with university students, and/or focused on schooling in extreme conditions (e.g., COVID-19). PRISMA guidelines were followed, through a search that resulted in the identification of 38 empirical quantitative studies, published between 2018 and 2022, in English.Results and discussionThe results revealed that parent and peer relationships impact students’ academic achievement and school engagement, as expected, and highlighted the relevance of parental and peer relationships for school-related outcomes. Future research should consider the role of potential mediators and moderators in the relationship between socio-emotional security and school outcomes.
Who gets to be an ELT course book author? Native speakerism in English for specific purposes and business English course books
Authors: Kiczkowiak Marek 
Published: October 2024

IntroductionNative speakerism has a profound influence on many aspects of ELT, for example negatively affecting job opportunities of those perceived as ‘non-native speakers’. Nevertheless, little is known about the effect of native speakerism on the recruitment of course book authors (CBAs).MethodsTherefore, this study analysed the linguistic and ethnic representation of 161 CBAs of 77 business English business English and English for specific purposes English for Specific Purposes course books (CBs) published globally by Pearson, OUP, CUP, Macmillan and NGL.ResultsThe data clearly show that publishers tend to hire white ‘native speakers’ from the UK as CBAs. More specifically, 90% of all CBA slots were taken by ‘native speakers’, 95% by white CBAs, and 78% by CBAs from the UK.DiscussionThis indicates a profound native speakerist bias among publishers against not only ‘non-native speakers’, but also those ‘native speakers’ who are not white or do not come from the UK. It is thus suggested that business English and English for Specific Purposes publishers pay greater attention to the diversity of the author teams they hire.
Anti-GABAB receptor encephalitis: clinical and laboratory characteristics, imaging, treatments and prognosis
Authors: Li Dongrui , Zong Shenghua , Yao Yaobing , Molenaar Peter C. , Damoiseaux Jan G. M. C. , Li Hui , Rouhl Rob P. W. , Martinez-Martinez Pilar 
Published: October 2024

IntroductionAnti-GABABR encephalitis is a rare disease reported to be often associated with tumors. The current study aims to summarize the clinical characteristics, imaging features, treatments, outcomes and explore the potential prognosis risk factors of patients with anti-GABABR encephalitis.MethodsPatients tested positive for anti-GABABR were retrospective studied from a single medical center in China over a period of 3 years. They were followed up for a maximum period of 18 months. Clinical data were summarized and prognostic factors including demographic characteristics, laboratory tests, and neurological functions were compared between survived and deceased patients at 18 months follow-up.ResultsTwenty-six patients, 10 females (38.5%) and 16 males (61.5%), diagnosed with anti-GABABR encephalitis were studied. The median age was 58 years. Of the 23 cases with complete clinical data, their main manifestations were epileptic seizures (65%), mental and behavioral abnormalities (52%), and cognitive impairment (48%). 7 (30.4%) cases had tumors: 5 small cell lung cancer (SCLC), 1 rectum adenocarcinoma (moderately differentiated) and 1 esophageal squamous cell carcinoma. MRI showed 5 (22%) cases had T2 FLAIR increased signals in cortex but with different regions affected. One of the two patients scanned for PET-CT showed hypermetabolism in the left temporal lobe region. The disease course ranged from 5 days to 3 years. 2 patients (one had esophageal carcinoma) without immunotherapy and 3 patients (one had SCLC) that did not response to immunotherapy died soon after diagnosis. 18 patients improved after immunotherapy while 3 (all had SCLC) died after relapses. The prevalence of epileptic seizures and malignancies was significantly lower in the survival group than in the deceased group at 18-months follow-up, the same as the admission mRs score. Serum fibrinogen, cerebrospinal fluid immunoglobulin G quotient, and 24-hour intrathecal synthesis rate were significantly lower in the survival groups as well.ConclusionsCortex T2 FLAIR abnormalities were only observed in a small proportion of anti-GABABR encephalitis patients with heterogeneous MRI phenotypes. High mRS score at admission, epileptic seizures and the presence of a tumor indicated a poor prognosis, while the underlying mechanism of the later two factors should be investigated further.
SHR-8068 combined with adebrelimab and bevacizumab in the treatment of refractory advanced colorectal cancer: study protocol for a single-arm, phase Ib/II study
Authors: Zhang Pei , Li Xiaofen , Wang Xin , Yang Yu , Wang Jianfei , Cao Dan 
Published: October 2024

BackgroundThe third-line treatment for refractory colorectal cancer (CRC) has limited efficacy. This study aimed to evaluate the safety and efficacy of SHR-8068 (an anti-CTLA-4 antibody), combined with adebrelimab (an anti-PD-L1 antibody), and bevacizumab in refractory non-microsatellite instability-high (MSI-H) or proficient mismatch repair (pMMR) CRC.MethodThis study is a prospective, open-label, single-center phase Ib/II clinical trial. Patients with pathologically confirmed pMMR/non-MSI-H metastatic colorectal adenocarcinoma who have failed ≥2 lines prior standard systemic treatments will be enrolled (n=36). The Ib phase will evaluate two dosing regimens of SHR-8068 in combination therapy (n=9 each dosage): SHR-8068 (1 mg per kilogram, every six weeks, intravenously) or SHR-8068 (4 mg per kilogram, every twelve weeks, intravenously) combined with adebrelimab (1200 mg, every three weeks, intravenously) and bevacizumab (7.5 mg per kilogram, every three weeks, intravenously). The efficacy and adverse events (AEs) of these regimens will be assessed to determine the recommended phase II dose (RP2D) of SHR-8068. Those of RP2D group from the phase Ib will be included in the phase II. The study will go to include 18 additional patients according to the one-sample log-rank test design in the phase II. The primary endpoint of the Ib phase is safety, with secondary endpoints including the objective response rate (ORR), progression-free survival (PFS), overall survival (OS), disease control rate (DCR), and quality of life (QOL). The primary endpoint for phase II was PFS, with secondary endpoints including ORR, OS, DCR, safety, and QOL. Identifying biomarkers to predict the efficacy of this regimen is the exploratory study endpoint.DiscussionThis proof-of-concept study would provide safety and efficacy signals of this novel combination treatment for the MSS CRCs in the late-line setting. And it may offer new insights on the clinical application of dual immunotherapy combined with anti-angiogenic therapy in the MSS CRC.
Role of interleukin-18 in mediating the impacts of celiac disease on osteoporosis: a Mendelian randomization study
Authors: Xiang Jie , Zheng Xiaoyu , Luo Lan , Yang Xiaoqiang 
Published: October 2024

BackgroundExtensive observational data suggest a link between celiac disease (CeD) and osteoporosis, but the causality and mediating mechanism remain undetermined. Herein, we performed a Mendelian randomization (MR) study to address these concerns.MethodsWe obtained the summary-level statistics for CeD from a large genome-wide association study (GWAS) comprising 4,533 cases and 10,750 controls of European ancestry. The GWAS data for osteoporosis-related traits and inflammatory cytokines were derived from the UK Biobank, FinnGen, IEU OpenGWAS database, or GWAS catalog. Two-sample MR with the inverse variance-weighted methods were employed to evaluate the genetic association between CeD and osteoporosis-related traits. The potential inflammatory mediators from CeD to osteoporosis were explored using two-step mediation analyses.ResultsThe primary MR analyses demonstrated causal associations between genetically predicted CeD and osteoporosis (odds ratio [OR]: 1.110, 95% confidence interval [CI]: 1.043–1.182, p=0.001), total body bone mineral density (β: -0.025, p=0.039), and osteoporotic fracture (OR: 1.124, 95% CI: 1.009–1.253, p=0.034). Extensive sensitivity analyses consolidated these findings. Among the candidate inflammatory cytokines, only interleukin-18 was observed to mediate the effects of CeD on osteoporosis, with an indirect OR of 1.020 (95% CI: 1.000–1.040, p=0.048) and a mediation proportion of 18.9%. The mediation effects of interleukin-18 could be validated in other datasets (OR: 1.015, 95% CI: 1.001–1.029, p=0.041). Bayesian colocalization analysis supported the role of interleukin-18 in osteoporosis.ConclusionThe present MR study reveals that CeD is associated with an increased risk of developing osteoporosis, which may be partly mediated by upregulation of interleukin-18.
Integrated analysis and experiments uncover the function of disulfidptosis in predicting immunotherapy effectiveness and delineating immune landscapes in uterine corpus endometrial carcinoma
Authors: Han Lei , Li Yilin , Yu Yanjie , Liu Guo , Gao Xiangqian , Wang Fei , Chen Weiwei , Xu Huishu , Zhang Baolin , Xu Yingjiang , Pan Yitong , Huang Yu , Yi Ping 
Published: October 2024

IntroductionRecently, a novel type of metabolic-regulated cell demise titled disulfidptosis has been discovered. Studies have demonstrated its importance in immune responses against cancer and its impact on the proliferation of cancer cells. Nonetheless, the precise mechanism and roles of disulfidptosis are not fully understood, particularly regarding the prognosis for individuals with uterine corpus endometrial carcinoma (UCEC).MethodsIn this research, a distinctive disulfidptosis pattern was developed in UCEC, and by utilizing Non-negative Matrix Factorization (NMF) on 23 disulfidptosis related genes within the TCGA database, 3 distinct subgroups were distinguished. To collect data, we acquired gene expression profiles, somatic mutation information, copy number variation data, and corresponding clinical data from the TCGA and GEO database, specifically from UCEC patients. Cell line experiments and immunohistochemical (IHC) staining were conducted to validate the role of the LRPPRC in proliferation, migration and invasion.ResultsThe genetic features and immune microenvironment of these subgroups were examined. It is worth mentioning that these subgroups offer important insights into comprehending the tumor microenvironment (TME) and the response of patients to immunotherapy and chemotherapy. Moreover, a disulfidptosis model was developed and validated, demonstrating a high level of accuracy in predicting the prognosis and outcomes of immunotherapy in UCEC patients. Additionally, a novel biomarker, LRPPRC, was identified, which can server as a promising predictor for forecasting prognosis in UCEC patients, with validation through tissue microarray staining and cell line experiments.DiscussionThis study has designed a classification system and a disulfidptosis model for UCEC, in addition to identifying a new biomarker, LRPPRC, for UCEC. These advancements serve as reliable and positive indicators for predicting outcomes and the efficacy of immunotherapy for each UCEC patient.