bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbapenem-ResistantEnterobacter hormaecheiUses Mucus Metabolism to Facilitate Gastrointestinal Colonization
Authors: Sinha Ritam , Ottosen Elizabeth N. , Ngwaga Tshegofatso , Shames Stephanie R. , DiRita Victor J. 
Published: September 2024

AbstractThe emergence and global spread of carbapenem-resistantEnterobacter cloacaecomplex species presents a pressing public health challenge. Carbapenem-resistantEnterobacterspecies cause a wide variety of infections, including septic shock fatalities in newborns and immunocompromised adults. The intestine may be a major reservoir for these resistant strains, either by facilitating contamination of fomites and transfer to susceptible individuals, or through translocation from the gut to the bloodstream. For this reason, we sought to establish a neonatal mouse model to investigate the mechanisms underpinning gut colonization by carbapenem-resistantEnterobacter hormaechei. We describe a new mouse model to study gut colonization byEnterobacterspecies, leading to vital insights into the adaptation of carbapenem-resistantE. hormaecheito the gut environment during the early stages of intestinal colonization. We observed successful colonization and proliferation ofE. hormaecheiin the five-day old infant mouse gut, with primary localization to the colon following oral inoculation. We also uncovered evidence thatE. hormaecheiuses mucus as a carbon source during colonization of the colon. Our findings underscore the importance of oxygen-dependent metabolic pathways, including the pyruvate dehydrogenase complex, andN-acetyl-D-glucosamine metabolism, in gut colonization and proliferation, which aligns with previous human studies. These insights are essential for developing novel therapeutic strategies that can serve as decolonization therapies in at-risk populations.ImportanceBloodstream infections caused byEnterobacterspecies pose a significant clinical threat. The intestine acts as the primary site for colonization and serves as a reservoir for infection. To combat this pathogen, it is crucial to understand how carbapenem-resistantEnterobacterspecies colonize the gut, as such knowledge can pave the way for alternative therapeutic targets. In this study, we developed a novel neonatal mouse model for gastrointestinal colonization byEnterobacterspecies and discovered that mucus plays a key role as a carbon source during colonization. Additionally, we identified two mucus catabolism pathways that contribute to intestinal colonization by carbapenem-resistantE. hormaechei. This new mouse model offers valuable insights into host-pathogen interactions and helps identify critical gastrointestinal fitness factors ofEnterobacter, potentially guiding the development of vaccines and alternative therapeutic strategies to minimize intestinal carriage in patient populations at risk for infection withEnterobacterspecies.
Candida albicansandStaphylococcus aureusreciprocally promote secretion of virulence factors
Authors: Pasman Raymond , Krom Bastiaan P. , Kramer Gertjan , Brul Stanley , Zaat Sebastian A.J. , Zhang Jianbo 
Published: September 2024

AbstractCo-infections ofCandida albicansandStaphylococcus aureuscan significantly increase morbidity and mortality. This synergism is linked to the interactions betweenC. albicansandS. aureusthat allow for staphylococcal co-invasion and dissemination. While it is known that extracellular virulence factors (ECVFs) contribute to this process, the effects ofC. albicans-S. aureusco-culturing on ECVF composition remain unknown. In this study we used mass spectrometry-based proteomics to investigate the effect of co-culturing on the extracellular proteins released by theS. aureusandC. albicans. Co- culturing ofC. albicansandS. aureuspromoted the secretion of 7 cytolytic, 11 proteolytic, and 3 lipolytic ECVFs. Interestingly, co-culturing ofC. albicansAls1p/Als3p mutant alleviated the increase for the majority of the differentially changedC. albicansECVFs, but not forS. aureusECVFs, highlighting the importance of Als1p/Als3p in the secretion ofC. albicansECVFs. Of 27 detectedS. aureusECVFs, 17 were significantly increased in co-culturing. Among these, maintenance of pH alone inS. aureusmonoculture increased five haemolytic proteins, i.e., alpha haemolysin (Hly/Hla), beta haemolysin (Hlb), and gamma haemolysin (HlgA-C) to a similar extent as the co-culture. In contrast, maintenance of pH diminished the increase of protease-like proteins, (phospho)lipases, delta hemolysin, and leukotoxin, suggesting that both pH-dependent and pH-independentC. albicansfactors affectS. aureusECVFs. A cytotoxicity assay demonstrated that the secretome from co-culture has higher cytotoxicity towards human oral cells (Ca 9-22 and HO1N1) than monoculture. Finally, co-culturing increased the levels of non-extracellular virulence factors from bothC. albicansandS. aureus. Taken together, the co-culturing ofC. albicansandS. aureusreciprocally promotes their virulence potential, which may provide insights into the synergistic lethality during their co-infectionin vivo.
Unveiling the dynamic capabilities' influence on sustainable performance in MSMEs: a systematic literature review utilizing ADO-TCM analysis
Authors: Mishra Ruchi , Kiran K.B. 
Published: September 2024

PurposeThis research endeavors to conduct a thorough and holistic analysis of the foundational elements that empower the cultivation of dynamic capabilities in micro, small and medium-sized enterprises (MSMEs). The purpose of this study is to determine whether these capabilities have a noticeable impact on the sustainable performance of these enterprises. The study aims to support future research efforts in understanding this phenomenon by filling this knowledge gap and presenting a conceptual framework, thereby enhancing the scholarly discourse in this field.Design/methodology/approachThe study consists of a systematic review of 126 articles meticulously chosen through a series of screening stages employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. This examination is conducted within the organized framework of antecedents, decisions and outcomes-theory, context and methods (ADO-TCM), ensuring a structured and comprehensive analysis.FindingsThe study uncovers significant insights, identifying four key antecedents: resource base, organizational learning, managerial expertise and external environment management. These factors are instrumental in fostering dynamic capabilities within the enterprise, leading to sustainable entrepreneurial success and a competitive advantage over rivals.Research limitations/implicationsBy comprehending the mechanisms by which dynamic capabilities are established within the enterprise, this study provides a valuable resource for entrepreneurs, professionals and managers, offering them practical insights to leverage.Originality/valueThis systematic literature review is the initial attempt to explain how dynamic capabilities can be used to enhance and accomplish sustainable performance in the context of MSMEs.
Food authenticity, culture, and tourism: analysing the dimensions of local gastronomic image among foreign tourists in Fiji
Authors: Gupta Vikas , Sharma Karishma 
Published: September 2024

PurposeThis research aims to assess the dimensions of local gastronomic image by identifying the vital gastronomic image traits utilised by foreign tourists for their evaluation of local foods while investigating any perceived disparities in the gastronomic image among Eastern and Western tourists.Design/methodology/approachIt combined mixed-methods research involving 17 in-depth interviews with restaurant stakeholders in Fiji and analysis of responses from 221 foreign tourists using multivariate and descriptive statistical methodologies. A total of 25 local gastronomic image traits were assessed to understand tourists’ perceptions, which were further refined into foundational constructs through exploratory factor analysis.FindingsResults highlighted that dishes like Kokoda, Palusami and Lovo are top favourites among both Eastern and Western tourists due to their less spicy nature. Findings also revealed that tourists positively evaluated four cognitive/perceptual dimensions of local gastronomic image: taste and freshness, culture and food authenticity, emotional food image, and quality and price value. Among all constructs, “freshness and taste” most significantly impacted foreign tourists’ satisfaction with their gourmet/culinary experiences, while “digestibility and nutritional value” showed the least value.Originality/valueThis research contributes to understanding how a destination’s gastronomic image influences tourists’ perceptions and how it can be effectively utilised to showcase the cultural uniqueness of destinations like Fiji.
Possibilities and missed opportunities for generative dialogue: professional networking, online platforms and the English classroom
Authors: Barber Chelsey , Fecho Bob 
Published: September 2024

Purpose
Social media is increasingly vital for educators to extend their professional networks and engage in meaningful conversations. This study aims to explore how Reddit facilitates these interactions as a platform for generative dialogical exchange. For English educators, generative dialogue is paramount for professional development and classroom practice.

Design/methodology/approach
To better understand this dynamic, we outline Hermans and Hermans-Konopka’s (2010) framework of generative dialogical exchange, review relevant literature related to the implications of social media use by educators and argue for the importance of Reddit as a site of exploration into dialogical exchange. After describing our artifact selection, we offer relevant data and conclude with understanding and implications.

Findings
We argue that although online educator communities, particularly those on Reddit, offer opportunities for broad dialogical exchange for English educators, these can be marked by a push and pull between the expansion of the dialogical space and a tendency to rein it back in through reinforcing traditional power dynamics.

Originality/value
Reddit is an understudied site for extending professional networks and fostering conversations among educators, providing a novel approach to understanding these dynamics through dialogical theory.
CEO characteristics and audit report lag: evidence from Egypt
Authors: Amin Mosa Abdelgelil , Abdelmaged Eman Mohamed , Ibrahim Awad Elsayed , Abdelfattah Tarek 
Published: September 2024

Purpose
This study aims to investigate the relationship between Chief Executive Officer (CEO) characteristics and audit report lag (ARL) in Egypt, an emerging economy characterized by high power distance and a culture of secrecy. The study utilizes a theoretical framework that integrates agency theory, stewardship theory, and upper echelons theory as the foundation for examining this relationship.

Design/methodology/approach
The sample consists of 587 firm-year observations from non-financial firms listed on the EGX100, covering the period from 2012 to 2019. The primary variable of the study (ARL) is measured using different proxies. The analysis utilizes both Ordinary Least Squares (OLS) and logistic regression models, with additional analysis considering CEO power and using board gender diversity as a moderating variable.

Findings
The study finds that CEO characteristics significantly affect ARL, demonstrating a negative association between CEO ownership, founder status, family ties, duality and ARL. These findings remain robust after a series of tests using alternative measures. Additional analysis reveals that CEO power is negatively and significantly related to ARL. Interestingly, the negative association between CEO characteristics and ARL is more pronounced in boards without female members.

Originality/value
Although extensive research has been conducted on the factors determining ARL, few studies have examined the impact of CEO characteristics on ARL, particularly in emerging economies such as Egypt. The business environment in Egypt is characterized by high power distance and a secretive culture, providing a unique context for this study.
Environmental messaging, corporate values, online engagement and purchase behavior: a study of green communications among eco-friendly coffee retailers
Authors: Suttikun Chompoonut , Mahasuweerachai Patcharaporn , Bicksler William Hamilton 
Published: September 2024

PurposeThis study aims to examine the influence of green message types on brand awareness and intention to share, and subsequently how perceived value leads to purchase intentions at green coffee retailers.Design/methodology/approachA 2 × 2 between-subjects design was developed, yielding four green advertising messages for the study. The structural relationships between variables were then tested by covariance-based structural equation modeling.FindingsThe most effective green advertising messages combined benefit-based text with images of green materials' benefits. These messages influenced consumers' perceived green awareness, intentions to share online ads and purchase intentions at green coffee retailers. Additionally, awareness of coffee retailers' green practices led to higher emotional value perception compared to other values. Emotional and functional values influenced purchase intentions at eco-friendly coffee retailers.Practical implicationsThe results of this study suggest effective ways of designing green advertising messages to increase consumer awareness of green products, sharing online ads and intentions to buy beverages from eco-friendly coffee retailers.Originality/valueThis study contributes to sustainability literature, dual coding theory and consumer value theory.
Exploring the relationship between functional diversity and growth in VC-backed new technology ventures
Authors: Bessagnet Arnauld , Abreu Arnaud 
Published: September 2024

PurposeDespite significant research attention to top management team diversity, the potential influence of other employees’ diversity on venture growth at different maturity stages such as middle management teams and nonmanagerial employees at the base of the organizational hierarchy remains largely overlooked. This study explores this relationship in new technology venture development, with a focus on the influence of functional skills diversity across different organizational levels and maturity stages.Design/methodology/approachThis study uses a linked employer–employee dataset covering new technology ventures in the digital industry that spans from 2010 to 2020. The sample includes 296 VC-backed new ventures located in the greater Paris (France) area. Through a problem-solving lens, the study examines functional skills at various organizational levels, including 5,243 top managers, 10,274 middle managers and 29,306 nonmanagerial employees.FindingsResults indicate that placing exclusive emphasis on top-level managers could lead to incorrect assignment of diversity effects as such effects are likely shared with lower organizational levels. In addition, the findings demonstrate that the diversity–venture growth relationship varies across new ventures’ funding stages, with a notably stronger correlation in the late stages of financing.Practical implicationsThis study demonstrates that promoting functional diversity across all organizational levels, not just top management, may boost firms’ growth. Furthermore, the effectiveness of functional diversity varies depending on the firm’s financing stage.Originality/valueThis study constructs a multilayered organizational framework to explore the relationship between diversity and new technology venture growth, using a fully reproducible skills diversity classification methodology that is applicable for future investigations.
Propofol attenuates prostate cancer progression by upregulating TRHDE‐AS1 expression, and METTL14 could mediate its m6A modification
Authors: Chen Zhuo , Li Quanfu , Li Zhong , Hu Guangjun 
Published: September 2024

AbstractPropofol has become a microtubule‐stabilizing drug for prostate cancer (PC) therapy, but propofol resistance impairs the therapeutic effect. This study aimed to explore the regulatory mechanism of propofol in the pathogenesis of PC through mechanisms involving N6‐methyladenosine (m6A) modification. The changes in PC cell malignancy were evaluated by means of transwell, cell counting kit 8 (CCK‐8), western blotting and tumour xenograft model assays. Long noncoding RNA TRHDE‐AS1 and m6A methyltransferase METTL14 expression levels were determined via reverse transcription quantitative polymerase chain reaction (RT‐qPCR). The m6A modification of TRHDE‐AS1 which was mediated by METTL14 was confirmed by conducting methylated RNA immunoprecipitation (MeRIP) assay. We observed that propofol (200 μM) inhibited PC cell malignancy in vivo and in vitro, elucidating that it impaired cell proliferation, migration and tumour growth but induced apoptosis. TRHDE‐AS1 expression was observed to be lower in PC cells and tissues, and propofol induced TRHDE‐AS1 upregulation in PC cells. Propofol was capable of reversing the tumour‐promoting effect of TRHDE‐AS1 knockdown in PC cells. Additionally, METTL14 was upstream of TRHDE‐AS1 to induce m6A modification of TRHDE‐AS1 in PC cells. Collectively, our results show that propofol prevents PC progression by upregulating TRHDE‐AS1 expression and METTL14 is involved in the m6A modification of TRHDE‐AS1. These findings suggest that TRHDE‐AS1 may be a potential therapeutic target for the improvement of propofol's therapeutic effect.
The Slope of the Phillips Curve and the Optimal Average Inflation Targeting Window
Authors: Lie Denny 
Published: September 2024

AbstractThe slope of the Phillips curve has been shown to be flatter in recent years, including in Australia. How does this impact the optimal targeting window for a central bank conducting an average inflation targeting policy? This article shows that, in the face of the flattening of the Phillips curve, it is desirable to increase the targeting window. Doing so would lead to lower inflation fluctuations and to a non‐trivial welfare gain. In a persistently higher‐than‐target inflation, high‐interest‐rate environment, this implies that the central bank should keep the nominal interest rate higher for longer.
Institutional, humane, therapeutic: Towards an understanding of caregiver violence through third sector violence prevention discourse in Finland
Authors: Sointu Liina 
Published: September 2024

AbstractViolence in family caregiving, once a social taboo, is now emerging as a topic of scientific inquiry. Engaging with a non‐normative approach to care and critical reflection on research of abusive caregiver behaviour and elder abuse, this study argues that as caregiver violence is increasingly addressed in research, it is crucial to understand it as a complex issue within its social context. The study adds to this understanding by conducting a discourse analysis of violence prevention programmes in Finland, where third sector organisations have taken the initiative in addressing caregiver violence. Based on analysis of project materials, media texts and expert interviews related to two such violence prevention programmes, the study illuminates how caregiver violence is made intelligible through a combination of three kinds of understanding: institutional, humane and therapeutic. It is suggested that these understandings offer a way forward in thinking about the complex, sensitive topic of caregiver violence in sociological research on care.
Coaching with care
Authors: Hoey Steve 
Published: September 2024

AbstractThis paper is a blend of my personal narrative and the practical strategies based on theoretical frameworks that I use in my work supporting young people in schools. My work is based on the powerful message from the short story the Starfish Thrower (Eiseley, 1979). The lesson I learned from this lovely story is that I may not be able to save the entire world, but I try to make a difference one young person at a time.
Prolonged exposure of implantable central venous access device salvaged by a simple local flap: A case report
Authors: Chow Tam‐Lin , Yu Peter S. M. 
Published: September 2024

AbstractBackgroundAn implantable central venous device is often used in patients when prolonged intravenous systemic therapy is anticipated for oncologic treatment. Exposure of a percutaneous implantable venous access device is a known complication that usually requires its removal.MethodsWe report a patient with a venous device implanted in the left arm, which was complicated by device exposure for 4 months. Clinically, there was no evidence of infection. The issue was addressed with a simple local flap for coverage.ResultsA local random fasciocutaneous flap was elevated under local anaesthesia and transferred to cover the exposed device as a day surgery. The wound healed uneventfully, with no recurrence of device exposure at the 3‐month follow‐up.ConclusionThe reported case supports flap coverage as an effective method for addressing exposed implantable venous devices, even with prolonged exposure, provided there is no infection.
Egg providers in eGoli
Authors: Moll Tessa 
Published: September 2024

AbstractIn South Africa's urban hubs, young women are increasingly participating in the global fertility market by donating their eggs. Egg providers, who supply oocytes for others’ use in fertility treatment, are a key resource in the fertility market, and they are emblematic of new forms of biolabor. Egg markets have tapped into a precariously middle‐class population of young Black women in Johannesburg, where the neoliberal state has largely retreated from fostering social mobility. What role does egg donation play in the social world of young South African women? I approach this question by extending Cohen's concept of “operability,” which can illuminate how egg donation becomes a means for young women to enact modernity, or relationality beyond the postapartheid state and the horizons of their social worlds, structured as they are by the entanglements of race, class, and gender.
Hypeful worlds
Authors: Neumark Tom 
Published: September 2024

AbstractContemporary technoscience is rife with hype—inflated claims that rapidly propagate in favor of the next “new thing.” While scholars often strive to debunk and dispel hype, Tanzanian technologists working in health care face a different challenge: navigating hype. As these technologists embark on new projects in machine learning and other forms of AI, contending with hype becomes crucial. These actors operate on the margins of global technoscientific worlds, aiming to create novel African futures that promote technological sovereignty. To do so, they must grapple with hype and its political economy. For anthropologists, merely transforming these technologists’ experiences into an ethnographic object won't teach us much; a much more illuminating task is to examine how their work can provoke us to refine and transform our own knowledge practices. This is especially important because their innovations can seem both inspiring and dispiriting, both entrenched in and opposed to the troublesome technological global order.