bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closed-loop quality control system for laser chemical machining in metal micro-production
Authors: Zhang P. , von Freyberg A. , Fischer A. 
Published: July 2017

AbstractSmall geometrical features in the scale of 10 to 400 μm can be produced on metallic workpieces with the laser-induced chemical etching process at low costs. However, the interactions among the subsystems of the laser chemical etching process, the mechanical positioning unit, the etchant pump, the laser source, and among the removal paths hinder the precise determination of the required process parameters for producing the desired geometry. For this reason, a closed-loop quality control is designed to compensate the deviations of quality features of a single removal and also of a workpiece produced by a sequence of removals. The developed control approach is based on inverse process models, which are used for a feed-forward control. Finally, a closed-loop control is achieved by designing an adaptive controller for the non-linear multi-inputs-multi-outputs process. The closed-loop control is realized as a production-discrete control by using a post-production measurement, and applied for producing a micro forming tool in the shape of a rectangular die. As a result, the laser chemical etching process is stabilized and, thus, the desired geometrical quality features of the workpiece are obtained with a reduced shape deviation of 2.4 μm.
Quantitative metabolomics of a xylose-utilizing Saccharomyces cerevisiae strain expressing the Bacteroides thetaiotaomicron xylose isomerase on glucose and xylose
Authors: Mert M J , Rose S H , la Grange D C , Bamba T , Hasunuma T , Kondo A , van Zyl W H 
Published: July 2017

Abstract
The yeast Saccharomyces cerevisiae cannot utilize xylose, but the introduction of a xylose isomerase that functions well in yeast will help overcome the limitations of the fungal oxido-reductive pathway. In this study, a diploid S. cerevisiae S288c[2n YMX12] strain was constructed expressing the Bacteroides thetaiotaomicron xylA (XI) and the Scheffersomyces stipitis xyl3 (XK) and the changes in the metabolite pools monitored over time. Cultivation on xylose generally resulted in gradual changes in metabolite pool size over time, whereas more dramatic fluctuations were observed with cultivation on glucose due to the diauxic growth pattern. The low G6P and F1,6P levels observed with cultivation on xylose resulted in the incomplete activation of the Crabtree effect, whereas the high PEP levels is indicative of carbon starvation. The high UDP-d-glucose levels with cultivation on xylose indicated that the carbon was channeled toward biomass production. The adenylate and guanylate energy charges were tightly regulated by the cultures, while the catabolic and anabolic reduction charges fluctuated between metabolic states. This study helped elucidate the metabolite distribution that takes place under Crabtree-positive and Crabtree-negative conditions when cultivating S. cerevisiae on glucose and xylose, respectively.
Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system
Authors: Kuchling Joseph , Brandt Alexander U , Paul Friedemann , Scheel Michael 
Published: July 2017

Abstract
The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS. Since MS damage patterns are believed to depend on multiple factors, i.e., ON (anterior visual pathway damage), inflammatory lesions (posterior visual pathway damage), and global diffuse inflammatory and neurodegenerative processes, comprehensive knowledge on different contributing factors using DTI in vivo may advance our understanding of MS disease pathology. Combination of DTI measures and visual outcome parameters yields the potential to improve routine clinical diagnostic procedures and may further the accuracy of individual prognosis with regard to visual function and personalized disease outcome. However, due to the inherent limitations of DTI acquisition and post-processing techniques and the so far heterogeneous and equivocal data of previous studies, evaluation of the true potential of DTI as a possible biomarker for afferent visual pathway dysfunction is still substantially limited. Further research efforts with larger longitudinal studies and standardized DTI acquisition and post-processing validation criteria are needed to overcome current DTI limitations. DTI evaluation at different levels of the visual pathway has the potential to provide markers for individual damage evaluation in the future. As an imaging biomarker, DTI may support individual outcome prediction during personalized treatment algorithms in MS and other neuroinflammatory diseases, hereby leveraging the concept of predictive, preventive, and personalized medicine in the field of clinical neuroimmunology.
Cost evaluation in design for end-of-Life of automotive components
Authors: Anthony Catherine , Cheung Wai M. 
Published: July 2017

Abstract
The European Union implemented the End-of-Life Vehicle directive to deal with an estimated 6 million end-of-life vehicles each year. Existing literature describe the processes to deal with the waste at end-of-life of different products but there is a lack of information on the costing of these options. These costs remain a concern to automotive manufacturers. This paper therefore reports the end-of-life costs of vehicle components and also demonstrates how these costs can be predicted at the design stage. The proposed approach should help to decide whether the automotive parts are viable for remanufacture, refurbishment, recycling, or disposal from an economic perspective. Two different automotive parts have been selected as case studies to validate the approach. Assumptions were made during the development of the technique and based on the results, the proposed approach could potentially provide vehicle manufacturers a method of estimating the cost of end-of-life recovery processes of vehicle components.
The role of esophagoscopy and imaging in the detection of second esophageal primary carcinomas in mucosal head and neck malignancy
Authors: Dezube Aaron R. , Lee Arnold , Rebeiz Elie 
Published: July 2017

Abstract

Objective
Esophagoscopy and/or barium swallow are routinely performed in the evaluation of patients with mucosal head and neck malignancies. Whether this intervention is efficient or cost-effective is questioned in our multidisciplinary head and neck tumor clinic. Our study objective is to find the yield provided by esophagoscopy and barium swallow, and the incidence of second primary cancers.

Study Design
Retrospective case series.

Methods
A retrospective chart review was done on patients treated at our institution for squamous cell carcinomas of the head and neck over a period of 8 years. The records of five hundred and ninety-four patients were analyzed to determine the method by which the cancer was diagnosed, the association with a particular region of the primary cancer, and the incidence of risk-increasing behavior.

Results
Five patients (0.84%) were found to have a second neoplasm of the esophagus. Of these, three patients (0.5%) had metachronous and two (0.34%) had a synchronous lesion. Three were diagnosed with barium swallow and two during routine endoscopy. The primary tumors were of the oral cavity in three patients and of the glottis and/or hypopharynx in two patients. All patients had a history of tobacco or alcohol abuse.

Conclusion
The incidence of a second cancer of the esophagus in head and neck cancer patients was low. Esophagoscopy and barium swallow are safe and reliable methods to detect an esophageal lesion.

Highlights
A focus on partisanship: How it impacts voting behaviors and political attitudes
Authors: Krishna Aradhna , Sokolova Tatiana 
Published: July 2017

AbstractThe target article by John Jost (2017 – this issue) focuses on political ideology (liberalism vs. conservatism) and its association with personal characteristics, cognitive processing style, and motivational interests. Jost's arguments and data are very compelling and will inspire consumer psychologists to do more research in the political domain. To enable this goal further, we complement the target article by focusing on partisanship, another major determinant of political judgments and decisions. Whereas political ideology refers to people being more liberal or conservative, partisanship refers to how strongly people identify with a specific political party (e.g., Republicans or Democrats). In reviewing the literature on partisanship, we concentrate on voting behaviors and attitudes, an area not addressed by Jost, but of great importance for consumer psychologists given the large expenditures on political advertising. Adding to Jost's discussion of the link between political ideology and systematic processing, we examine the interplay between these two constructs and partisanship.
Gambogic acid improves non‐small cell lung cancer progression by inhibition of mTOR signaling pathway
Authors: Zhao Teng , Wang Hong‐Jian , Zhao Wen‐Wen , Sun Yi‐Ling , Hu Li‐Kuan 
Published: July 2017

AbstractGambogic acid (GA) has been shown to inhibit cancer cell proliferation, induce apoptosis, and enhance reactive oxygen species accumulation. However, whether GA could improve multidrug resistance through modulating autophagy has never been explored. We demonstrated that the combination of GA and cisplatin (CDDP) resulted in a stronger growth inhibition effect on A549 and NCI‐H460 cells using the MTT assay. Furthermore, treatment with GA significantly increased autophagy in these cells. More importantly, GA‐induced cell death could be largely abolished by 3‐methyladenine (3‐MA) or chloroquine (CQ) treatment, suggesting that GA‐induced cell death was dependent on autophagy. Western blot analysis showed that GA treatment suppressed the activation of Akt, mTOR, and S6. In addition, using a GA and rapamycin combination induced more cell death compared to either GA or rapamycin alone. In summary, GA may have utility as an adjunct therapy for non‐small cell lung cancer (NSCLC) patients through autophagy‐dependent cell death, even when cancer cells have developed resistance to apoptosis.
GENOTYPIC DIFFERENCES IN CARDINAL TEMPERATURES FOR IN VITRO POLLEN GERMINATION AND POLLEN TUBE GROWTH OF COCONUT HYBRIDS
Authors: RANASINGHE C. S. , KUMARATHUNGE M. D. P. , KIRIWANDENIYA K. G. S. 
Published: July 2017

SUMMARYSuccessful fruit set in coconut depends on several reproductive processes including pollen germination and pollen tube growth. High temperature (˃33 °C) during flowering reduces fruit set in coconut. Therefore, identification and development of coconut varieties or hybrids with high reproductive heat tolerance will benefit the coconut industry in view of the climate changes. This experiment was conducted to quantify the response of pollen germination and pollen tube growth of seven coconut hybrids to increasing temperature from 16 to 38 °C. A Principal Component Analysis (PCA) was carried out to classify coconut hybrids on the basis of their temperature tolerances to pollen germination. Pollen germination and pollen tube length of the hybrids ranged from 56 to 78% and 242 to 772 µm, respectively. A modified bilinear model best described the response to temperature of pollen germination and pollen tube length. Cardinal temperatures (Tmin, Topt and Tmax) of pollen germination and pollen tube length varied among the seven hybrids. PCA identified Tmax for pollen germination and Topt for pollen tube length as the most important parameters in describing varietal tolerance to high temperature. PCA also identified SLGD × Sri Lanka Tall and Sri Lanka Brown Dwarf × Sri Lanka Tall as the most tolerant hybrids to high temperature stress and Sri Lanka Tall × Sri Lanka Tall and Sri Lanka Green Dwarf × San Ramon as less tolerant ones based on cardinal temperatures for pollen germination and pollen tube length. Tmax for pollen germination of the most tolerant and less tolerant hybrids were 41.9 and 39.5 °C, respectively. Topt for pollen tube length in the most tolerant and less tolerant hybrids were 29.5 and 26.0 °C, respectively.
‘Parity of Participation’ and the Politics of Needs Interpretation: Engagement with Roma Migrants in Manchester
Authors: COOLS PIETER , LEGGIO DANIELE VIKTOR , MATRAS YARON , OOSTERLYNCK STIJN 
Published: July 2017

AbstractService providers in Western welfare states have to engage with an increasingly differentiated citizenry. The arrival of new migrant communities triggers debates, negotiations and struggles over the needs of these communities and how service providers can engage with them. In this paper, we look at these processes of developing local social inclusion policies that target migrant communities through the perspective of Nancy Fraser's ‘politics of need interpretation’. More specifically, we analyse Roma engagement strategies in Manchester. We do so by reconstructing how the presence of Romanian Roma emerged as a public issue leading to various engagement strategies and how different actors competed over the interpretation of the needs of the Roma community and the best ways to respond to them. We use Fraser's notion of ‘parity of participation’ to draw attention to the position of the Roma community itself in the process of interpreting needs.
Characterization of group B coxsackieviruses isolated from non-polio acute flaccid paralysis patients in Pakistan: vital assessment before polio eradication
Authors: ANGEZ M. , SHAUKAT S. , ZAHRA R. , ALAM M. M. , SHARIF S. , KHURSHID A. , ARSHAD Y. , SULEMAN M. , MUJTABA G. , ZAIDI S. S. Z. 
Published: July 2017

SummaryPakistan is at the verge of polio eradication but isolation of non-polio enteroviruses (NPEVs) from acute flaccid paralysis (AFP) cases may result in serious or even fatal outcome. Many enteroviruses share similar symptoms and epidemiology as is the case with poliovirus and coxsackievirus (CV). The present study was designed to genetically characterize coxsackievirus B (CV-B) serotypes isolated from non-polio acute flaccid paralytic children, as well as to understand their probable role in paralysis. A total of 63 (20·1%) out of 313 stool samples during 2013 were found positive for NPEVs in rhabdomyosarcoma cells. Only 24 (38·0%) NPEVs were typed as CV-B by microneutralization assay and were further characterized by sequencing of the viral protein 1 (VP1) gene. Molecular phylogenetic analyses classified the study strains into six coxsackievirus B serotypes (coxsackievirus B1 to B6) with their respective prototype strains with evidence of epidemiological linkage and distinct clusters. Moreover, four major differences were found within the amino acid sequences of BC-loop in VP1 of CV-B strains. In conclusion, this study presented the molecular evolutionary genetic overview and distinct phylogenetic pattern of CV-B isolates from AFP cases in Pakistan, and explored the possible link between CV-B infections and AFP cases. Furthermore, our data reveal that these viruses might contribute to the incidence of paralysis in population and there is need of time to establish an enterovirus surveillance system for better understanding of epidemiological and virological characteristics of NPEV infections associated with AFP cases in the country.
Regional relationships among the low vowels of U.S. English: Evidence from production and perception
Authors: Kendall Tyler , Fridland Valerie 
Published: July 2017

AbstractThe unconditioned merger of the low back vowels and the variety of realizations found for the low front vowel have been noted as leading to greater distinctiveness across U.S. English regional dialects. The extent to which the movements of these vowels are related has repeatedly been of interest to dialectology as well as phonological theory. Here, examining production and perception data from speaker-listeners across three major regions of the United States, the relationships among these low vowels within and across regions are investigated. Participants provided speech samples and took part in a vowel identification task, judging vowels along a continuum from /æ/ to /ɑ/. Results of acoustic analysis and statistical analysis of the perception results indicate that a structural relationship between /æ/ and /ɑ/ is maintained across regions and that listeners’ own degree of low back vowel merger predicts their perception of the boundary between /æ/ and /ɑ/.
There's three variants: Agreement variation in existentialthereconstructions
Authors: Krejci Bonnie , Hilton Katherine 
Published: July 2017

AbstractPrevious studies of agreement variation in existentialthereconstructions treat the variable as binary, distinguishing between agreeing and nonagreeing variants. Using new data from a corpus of English spoken in California, we argue that this widely studied variable cannot be fully understood without instead making a three-way distinction between agreement (there are/were+ plural), nonagreement using a full form of the verb (there is/was+ plural), and nonagreement usingthere's. We motivate this three-way distinction by showing that the two nonagreeing variants differ in their distributions with respect to polarity and determiner type, as well as speaker age and education level. Full form nonagreement is more frequent among speakers with less formal education, whilethere'sis favored by younger speakers. These results suggest that the two nonagreeing variants differ in their longitudinal trajectories, a finding that would be obscured in an analysis that makes only a binary distinction between variants.
New insights into an old form: A variationist analysis of the pleonastic possessive in Guatemalan Spanish
Authors: Elsig Martin 
Published: July 2017

AbstractRomance languages differ as regards the adjectival or article-like status of prenominal possessives. While in Italian, Portuguese, Catalan, and Old Spanish, they pattern like adjectives and co-occur with articles, and in French and Modern Spanish, they compete with the latter for the same structural position. The different distribution of possessives is claimed to reflect distinct stages on a grammaticalization cline (Alexiadou, 2004). This paper focuses on a variety of Central American Spanish where the Old Spanish co-occurrence of an (indefinite) article and a possessive in the prenominal domain has been maintained (as inuna mi amiga‘a my friend’). Based on a variationist study of interview data extracted from the Project for the Sociolinguistic Study of Spanish for Spain and America (PRESEEA) Guatemala corpus, I will argue that it is indeed the indefinite article that shows signs of retarded grammaticalization. Yet, rather than extending to the variety as a whole, this retardation is context-specific.
‘Crying Out With Life and Truth’: Simulating Immersion in Messiaen'sDes Canyons aux étoiles. . .
Authors: COCHRAN TIMOTHY B. 
Published: July 2017

AbstractInDes Canyons aux étoiles. . ., a work commissioned to celebrate the American bicentennial, Olivier Messiaen defines the United States through representations of Utah's birds and canyons. Focusing on the phenomenological power rather than the pictorial intentions of Messiaen's music, this article examines ways that Messiaen uses textural saturation and varied repetition to draw the listener into a musically mediated Bryce Canyon. The music challenges a stable subject/object relationship for the listener by promoting humility and awe within the landscape over more visually oriented touristic encounters. Simulations of immersion serve implicit political and evangelistic goals as city-dwelling listeners are invited to embrace dwelling in the natural environment as a means of revaluing faith and breaking free from what Messiaen perceived as the twin hindrances of mechanized civilization and secularism.
Vera Lynn on Screen: Popular Music and the ‘People's War’
Authors: GUTHRIE KATE 
Published: July 2017

AbstractBy the outbreak of the Second World War in Britain, critics had spent several decades negotiating the supposed distinctions between highbrow and lowbrow culture, as recent scholarship has shown. What has received comparatively little attention is how the demands of wartime living changed the stakes of the debate. This article addresses this lacuna, exploring how war invited a reassessment of the relative merits of art and popular music. Perhaps the most iconic British singer of the period, Vera Lynn provides a case study. Focusing on her first film vehicle,We'll Meet Again(1942), I explore how Lynn's character mediated the highbrow/lowbrow conflict – for example, by presenting popular music as a site of community, while disparaging art music for its minority appeal. In so doing, I argue, the film not only promoted Lynn's star persona, but also intervened in a broader debate about the value of entertainment for a nation at war.
Growth arrest and a persister state enable resistance to osmotic shock and facilitate dissemination of Vibrio cholerae
Authors: Silva-Valenzuela Cecilia A , Lazinski David W , Kahne Shoshanna C , Nguyen Y , Molina-Quiroz Roberto C , Camilli Andrew 
Published: July 2017

Abstract
Vibrio cholerae is a water-borne bacterial pathogen and causative agent of cholera. Although V. cholerae is a halophile, it can survive in fresh water, and this has a major role in cholera epidemics through consumption of contaminated water and subsequent fecal–oral spread. After dissemination from humans back into fresh water, V. cholerae encounters limited nutrient availability and an abrupt drop in conductivity but little is known about how V. cholerae adapts to, and survives in this environment. In this work, by abolishing or altering the expression of V. cholerae genes in a high-throughput manner, we observed that many osmotic shock tolerant mutants exhibited slowed or arrested growth, and/or generated a higher proportion of persister cells. In addition, we show that growth-arrested V. cholerae, including a persister subpopulation, are generated during infection of the intestinal tract and together allow for the successful dissemination to fresh water. Our results suggest that growth-arrested and persister subpopulations enable survival of V. cholerae upon shedding to the aquatic environment.