bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion tensor imaging marks dopaminergic and serotonergic lesions in the Parkinsonian monkey
Authors: Météreau Elise , Beaudoin‐Gobert Maude , Duperrier Sandra , Thobois Stéphane , Tremblay Léon , Sgambato‐Faure Véronique 
Published: October 2017

ABSTRACTBackgroundDiffusion tensor imaging has received major interest to highlight markers of neurodegeneration in Parkinson's disease. Whether the alteration of diffusion parameters mostly depicts dopaminergic lesions or can also reveal serotonergic denervation remains a question.ObjectivesThe aim of this study was to determine the best diffusion tensor imaging markers of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and 3,4‐methylene‐dioxy‐methamphetamine (MDMA; also known as ecstasy) lesions in the nonhuman primate.MethodsWe acquired measures of mean diffusivity and fractional anisotropy longitudinally (before and after MPTP and MDMA) and correlated them with severity of parkinsonism, PET imaging, and postmortem fiber quantification.ResultsMPTP‐induced lesions were associated with increases of mean diffusivity within both the caudate nucleus and the anterior cingulate cortex, whereas MDMA‐induced lesions caused an increase of fractional anisotropy within the caudate nucleus. These variations of diffusion tensor imaging correlated with the motor score.ConclusionTaken together, these results demonstrate that diffusion measures within specific brain regions can mark severity of dopaminergic and serotonergic induced lesions in a neurotoxic nonhuman primate model of Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society
Pilot study: Assessing the effect of continual position monitoring technology on compliance with patient turning protocols
Authors: Schutt Suann Cirigliano , Tarver Christine , Pezzani Michelle 
Published: October 2017

AbstractAimThe study aim was to evaluate if continual patient position monitoring, taking into account self‐turns and clinician‐assisted turns, would increase the percentage of time a patient's position changed at least every 2 hr.BackgroundWhile patient turning has clinical benefits, current models to help staff remember to turn patients, such as “turn clocks” and timers, have not resulted in high compliance with turning protocols. In addition, reminders are based on arbitrary 2‐hr windows (such as turning on “even” hours) rather than on individual patient activity, including self‐turns.DesignThis is a first inpatient, non‐randomized, pre‐/postintervention study.MethodsData collection occurred from May 2013–February 2014 on a 39‐bed medical unit in a community hospital. Baseline patient turning data were recorded by a sensor; however, the patient data were not displayed at the nurses’ station to establish compliance with the hospital's turning protocol. Postintervention, patient position information was wirelessly displayed on nurses’ station computer monitors in real time. A Student t test was used to compare baseline to postintervention “mean time in compliance.”ResultsData from 138 patients (N = 7,854 hr of monitoring) were collected. The baseline phase yielded 4,322 hr of position monitoring data and the postintervention phase yielded 3,532 hr of data. Statistically significant improvement was demonstrated in the percentage of time a patient's position changed at least every 2 hr from baseline to postintervention.
Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literature—A report from the SIOP Renal Tumor Study Group
Authors: Hol Janna A. , van den Heuvel‐Eibrink Marry M. , Graf Norbert , Pritchard‐Jones Kathy , Brok Jesper , van Tinteren Harm , Howell Lisa , Verschuur Arnauld , Bergeron Christophe , Kager Leo , Catania Serena , Spreafico Filippo , Mavinkurve‐Groothuis Annelies M. C. 
Published: October 2017

AbstractWhile irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan‐containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate‐risk (CR and PR) and blastemal‐type histologies (PR). Two patients were alive at last follow‐up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.
Gene therapy for hemophilia
Authors: Pipe Steven W. 
Published: October 2017

AbstractIndividuals with the inherited bleeding disorder hemophilia have achieved tremendous advances in clinical outcomes through widespread implementation of prophylactic replacement with safe and efficacious factor VIII and IX. However, despite this therapeutic approach, bleeds still occur, some with serious consequence, joint disease has not been eradicated, and patients have not yet been liberated from the need for regular intravenous infusions. The shift from protein replacement to gene replacement is offering great hope to achieve durable levels of plasma factor activity levels high enough to remove the risk for recurrent joint bleeding. For the first time, clinical trial results are showing promise for “curative” correction of the bleeding phenotype.
The duration of anthracycline infusion should be at least one hour in children with cancer: A clinical practice guideline
Authors: Loeffen Erik A.H. , van Dalen Elvira C. , Mulder Renée L. , van de Wetering Marianne D. , Kremer Leontien C.M. , Tissing Wim J.E. ,   on behalf of the Anthracycline Cardiotoxicity Working Group
Published: October 2017

AbstractWe aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer. This study also serves as a practice example of the essential steps that need to be taken when using a previously published systematic review to develop a high‐quality clinical practice guideline. Although evidence was scarce and included adult studies, the panel was able (using the Grading of Recommendations Assessment, Development and Evaluation evidence‐to‐decision framework) to recommend in favor of an anthracycline infusion duration of at least 1 hr (strong recommendation, very low to moderate quality of evidence). Recommending a precise optimal prolonged infusion duration was currently not possible.
Addressing inequity in special education: An integrated framework for culturally responsive social emotional practice
Authors: Sciuchetti Maria B. 
Published: October 2017

AbstractDespite great strides toward equity and inclusion of all students, the disproportionate representation of students from culturally and linguistically diverse (CLD) backgrounds has been an issue of concern within the field of special education for decades. Of particular concern is the disproportionate representation of students from CLD backgrounds among students served within the category of emotional disturbance and students faced with exclusionary disciplinary decisions. This paper presents an overview of literature related to school‐ and teacher‐based factors that contribute to these issues of disproportionality. It concludes with the recommendation for an integrated framework of culturally responsive practice and social emotional learning as an approach to target these factors.
Folding nucleus structure persists in thermally‐aggregated FGF‐1
Authors: Longo Liam M. , Gao Yuan , Tenorio Connie A. , Wang Gan , Paravastu Anant K. , Blaber Michael 
Published: October 2017

AbstractAn efficient protein‐folding pathway leading to target structure, and the avoidance of aggregation, is essential to protein evolution and de novo design; however, design details to achieve efficient folding and avoid aggregation are poorly understood. We report characterization of the thermally‐induced aggregate of fibroblast growth factor‐1 (FGF‐1), a small globular protein, by solid‐state NMR. NMR spectra are consistent with residual structure in the aggregate and provide evidence of a structured region that corresponds to the region of the folding nucleus. NMR data on aggregated FGF‐1 also indicate the presence of unstructured regions that exhibit hydration‐dependent dynamics and suggest that unstructured regions of aggregated FGF‐1 lie outside the folding nucleus. Since it is known that regions outside the folding nucleus fold late in the folding pathway, we postulate that these regions unfold early in the unfolding pathway and that the partially folded state is more prone to intermolecular aggregation. This interpretation is further supported by comparison with a designed protein that shares the same FGF‐1 folding nucleus sequence, but has different 1° structure outside the folding nucleus, and does not thermally aggregate. The results suggest that design of an efficient folding nucleus, and the avoidance of aggregation in the folding pathway, are potentially separable design criteria – the latter of which could principally focus upon the physicochemical properties of 1° structure outside the folding nucleus.
Prediction of protein disorder based on IUPred
Authors: Dosztányi Zsuzsanna 
Published: October 2017

AbstractMany proteins contain intrinsically disordered regions (IDRs), functional polypeptide segments that in isolation adopt a highly flexible conformational ensemble instead of a single, well‐defined structure. Disorder prediction methods, which can discriminate ordered and disordered regions from the amino acid sequence, have contributed significantly to our current understanding of the distinct properties of intrinsically disordered proteins by enabling the characterization of individual examples as well as large‐scale analyses of these protein regions. One popular method, IUPred provides a robust prediction of protein disorder based on an energy estimation approach that captures the fundamental difference between the biophysical properties of ordered and disordered regions. This paper reviews the energy estimation method underlying IUPred and the basic properties of the web server. Through an example, it also illustrates how the prediction output can be interpreted in a more complex case by taking into account the heterogeneous nature of IDRs. Various applications that benefited from IUPred to provide improved disorder predictions, complementing domain annotations and aiding the identification of functional short linear motifs are also described here. IUPred is freely available for noncommercial users through the web server (http://iupred.enzim.hu and http://iupred.elte.hu) . The program can also be downloaded and installed locally for large‐scale analyses.
A risk‐based approach for predicting domino effects due to fires combining exceedance curves with dynamic thermal stress analysis
Authors: Dunjó Denti Jordi , Amorós‐Martí Marcel , Prophet Neil , Gorski Gene 
Published: October 2017

This article proposes a risk‐based method for domino effect characterization and potential escalation for process equipment affected by thermal radiation (i.e., fires). This methodology intends to answer two key questions: (1) which process equipment is impacted by a heat flux capable of resulting in escalation due to equipment failure; and (2) what is the associated time to the process equipment failure; that is, Time to Failure (TTF). The first phase consists of developing dedicated heat flux exceedance curves for a given location of interest. The second phase involves a dynamic simulation for the prediction of the TTF due to fires impacting the equipment identified in phase one. A two‐step approach is proposed for ensuring accurate results: (1) vessel wall segmentation to determine how the Ultimate Tensile Strength (UTS) of the material decreases as a function of temperature, and (2) the UTS is then compared with the Hoop stress by considering the equipment internal pressure combined with the installed overpressure protection performance.This article defines step‐by‐step how to conduct a risk‐based assessment and determine the TTF using a case study. It demonstrates the applicability and accuracy of this approach, which helps the decision‐making process on how potential mitigation measures can be implemented. © 2017 American Institute of Chemical Engineers Process Saf Prog 37: 176–185, 2018
Substituent effects on the stability of 1,4‐benzodiazepin‐2‐one tautomers: A density functional study
Authors: Pem Barbara , Vrček Valerije 
Published: October 2017

AbstractThe relative stability of 1,4‐benzodiazepin‐2‐one tautomers in the gas phase and model solvents was calculated at the M06 and ωB97XD levels of theory. The two density functionals were benchmarked earlier and demonstrated as excellent models to study tautomerism in a vast array of chemical systems. A number of commercially available 1,4‐benzodiazepin‐2‐ones were investigated computationally for the first time. In addition, some biologically active and newly devised benzodiazepines were considered, which may be important in designing structures with desired (bio)chemical features. Special attention was paid to determine substituent effects on the Gibbs free energies of keto, enol, and iminol forms for each respective benzodiazepine. It was demonstrated that (i) the replacement of the benzene ring by the heterocyclic ring in the benzodiazepine system may stabilize the iminol tautomer, and (ii) the electron‐withdrawing substituent at the C3‐position of the respective benzodiazepine may stabilize the enol tautomer relative to the parent keto form. It is concluded that substituent effects may govern the chemical reactivity and biological properties of selected benzodiazepines.
Spatial and temporal distribution of ichthyoplankton during an unusual period of low flow in a tributary of the São Francisco River, Brazil
Authors: Rosa G.R. , Salvador G.N. , Bialetzki A. , Santos G.B. 
Published: October 2017

AbstractFlow‐dependent fish specialists require specific conditions for reproduction, so the success and reproductive intensity of these animals are determined by the flood regime. Thus, this study investigated the spatial and temporal reproductive patterns of fish, especially migratory Prochilodus species (flow‐dependent specialists) in an unusual period of low flow in the Pará River sub‐basin, one of the main tributaries of the upper São Francisco River. For this, ichthyoplankton collections were carried out between November 2013 and February 2014. Data were analysed considering the spatial and temporal variations in density of eggs and larvae for the upper, middle, and lower portions of the Pará River sub‐basin, and correlating this to some environmental variables. The results showed that the small headwater stretch of the Pará River is one relevant spawning area for migratory fish species. However, this area is isolated by the Cajuru reservoir, which makes it uncertain the recruitment of these embryos, due to interruption of natural drift between spawning/nursery areas caused for reservoirs. Larvae of newly hatched migratory species found in tributaries of the lower Pará River sub‐basin also indicate these species use these tributaries as spawning grounds and migratory routes. The period in which the research was conducted represented the most atypical low flow, one in the last 75 years, resulting in the low variability in the environmental parameters. Although few parameters increased briefly in this low flow period influenced by greater rainfall in December, this precipitation was possibly responsible for the final gonadal maturation and spawning of migratory species.
Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine
Authors: Samsonraj Rebekah M. , Raghunath Michael , Nurcombe Victor , Hui James H. , van Wijnen Andre J. , Cool Simon M. 
Published: October 2017

AbstractMesenchymal stem cells (MSC) hold great potential for regenerative medicine because of their ability for self-renewal and differentiation into tissue-specific cells such as osteoblasts, chondrocytes, and adipocytes. MSCs orchestrate tissue development, maintenance and repair, and are useful for musculoskeletal regenerative therapies to treat age-related orthopedic degenerative diseases and other clinical conditions. Importantly, MSCs produce secretory factors that play critical roles in tissue repair that support both engraftment and trophic functions (autocrine and paracrine). The development of uniform protocols for both preparation and characterization of MSCs, including standardized functional assays for evaluation of their biological potential, are critical factors contributing to their clinical utility. Quality control and release criteria for MSCs should include cell surface markers, differentiation potential, and other essential cell parameters. For example, cell surface marker profiles (surfactome), bone-forming capacities in ectopic and orthotopic models, as well as cell size and granularity, telomere length, senescence status, trophic factor secretion (secretome), and immunomodulation, should be thoroughly assessed to predict MSC utility for regenerative medicine. We propose that these and other functionalities of MSCs should be characterized prior to use in clinical applications as part of comprehensive and uniform guidelines and release criteria for their clinical-grade production to achieve predictably favorable treatment outcomes for stem cell therapy.
In Situ Fabrication of Hierarchically Branched TiO2 Nanostructures: Enhanced Performance in Photocatalytic H2 Evolution and Li–Ion Batteries
Authors: Yang Guorui , Wang Ling , Peng Shengjie , Wang Jianan , Ji Dongxiao , Yan Wei , Ramakrishna Seeram 
Published: October 2017

Abstract1D branched TiO2 nanomaterials play a significant role in efficient photocatalysis and high‐performance lithium ion batteries. In contrast to the typical methods which generally have to employ epitaxial growth, the direct in situ growth of hierarchically branched TiO2 nanofibers by a combination of the electrospinning technique and the alkali‐hydrothermal process is presented in this work. Such the branched nanofibers exhibit improvement in terms of photocatalytic hydrogen evolution (0.41 mmol g−1 h−1), in comparison to the conventional TiO2 nanofibers (0.11 mmol g−1 h−1) and P25 (0.082 mmol g−1 h−1). Furthermore, these nanofibers also deliver higher lithium specific capacity at different current densities, and the specific capacity at the rate of 2 C is as high as 201. 0 mAh g−1, roughly two times higher than that of the pristine TiO2 nanofibers.
Dual‐Graphene Rechargeable Sodium Battery
Authors: Wang Faxing , Liu Zaichun , Zhang Panpan , Li Hongyan , Sheng Wenbo , Zhang Tao , Jordan Rainer , Wu Yuping , Zhuang Xiaodong , Feng Xinliang 
Published: October 2017

AbstractSodium (Na) ion batteries are attracting increasing attention for use in various electrical applications. However, the electrochemical behaviors, particularly the working voltages, of Na ion batteries are substantially lower than those of lithium (Li) ion batteries. Worse, the state‐of‐the‐art Na ion battery cannot meet the demand of miniaturized in modern electronics. Here, we demonstrate that electrochemically exfoliated graphene (EG) nanosheets can reversibly store (PF6−) anions, yielding high charging and discharging voltages of 4.7 and 4.3 V vs. Na+/Na, respectively. The dual‐graphene rechargeable Na battery fabricated using EG as both the positive and negative electrodes provided the highest operating voltage among all Na ion full cells reported to date, together with a maximum energy density of 250 Wh kg−1. Notably, the dual‐graphene rechargeable Na microbattery exhibited an areal capacity of 35 μAh cm−2 with stable cycling behavior. This study offers an efficient option for the development of novel rechargeable microbatteries with ultra‐high operating voltage and high energy density.
Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation
Authors: Harting Matthew T. , Srivastava Amit K. , Zhaorigetu Siqin , Bair Henry , Prabhakara Karthik S. , Toledano Furman Naama E. , Vykoukal Jody V. , Ruppert Katherine A. , Cox Charles S. , Olson Scott D. 
Published: October 2017

Abstract
Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) have been proposed to be a key mechanistic link in the therapeutic efficacy of cells in response to cellular injuries through paracrine effects. We hypothesize that inflammatory stimulation of MSCs results in the release of EVs that have greater anti-inflammatory effects. The present study evaluates the immunomodulatory abilities of EVs derived from inflammation-stimulated and naive MSCs (MSCEv+ and MSCEv, respectively) isolated using a current Good Manufacturing Practice-compliant tangential flow filtration system. Detailed characterization of both EVs revealed differences in protein composition, cytokine profiles, and RNA content, despite similarities in size and expression of common surface markers. MSCEv+ further attenuated release of pro-inflammatory cytokines in vitro when compared to MSCEv, with a distinctly different pattern of EV-uptake by activated primary leukocyte subpopulations. The efficacy of EVs was partially attributed to COX2/PGE2 expression. The present study demonstrates that inflammatory stimulation of MSCs renders release of EVs that have enhanced anti-inflammatory properties partially due to COX2/PGE2 pathway alteration.
Modeling of stable cyclic stress‐strain responses under non‐proportional loading
Authors: Li Jing , Li Chun‐wang , Zhang Zhong‐ping 
Published: October 2017

AbstractThis paper proposes a simple two‐surface plasticity model for strain controlled conditions which includes only five material constants to describe the stable stress‐strain relationship under extensive non‐proportional loadings. In this model, the Mróz kinematic hardening rule is adopted to describe the instantaneous translation of the yield surface, and a larger radius of the limit surface is selected to avoid overlapping of the one with the limit surface. A non‐proportionality measure of strain path on the basis of the minimum normal strain range is proposed. Procedures to determine the minimum normal strain range are also presented for general multiaxial loadings. The proposed two‐surface model is relatively convenient to be used since it is not overly sensitive to the modeling parameters. Four kinds of material (type 304 stainless steel, S460N steel, 30CrNiMo8HH steel, and 1%CrMoV steel) tested under strain controlled conditions are used to validate the reliability of the proposed model. Comparisons between test results and model predictions under 19 types of nonproportional strain paths show that the proposed model predicts relatively accurate stress responses under non‐proportional loading paths by introducing non‐proportional cyclic hardening coefficient and non‐proportionality factor into the developed evolution equations.
National Society of Genetic Counselors Code of Ethics
Authors:   The National Society of Genetic Counselors
Published: October 2017

AbstractThis document is the revised Code of Ethics of the National Society of Genetic Counselors (NSGC) that was adopted in April 2017 after majority vote of the full membership of the NSGC. The explication of the revisions is published in this volume of the Journal of Genetic Counseling. This is the fourth revision to the Code of Ethics since its original adoption in 1992.