bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury
Authors: Patil Naeem K , Luan Liming , Bohannon Julia K , Hernandez Antonio , Guo Yin , Sherwood Edward R 
Published: December 2017

Abstract
Burn patients are susceptible to infections due, in part, to immune dysfunction. Upregulation of programmed death-1 (PD-1) receptor on T cells and programmed cell death ligand-1 (PD-L1) on myeloid cells contribute to immune dysfunction in nonburn-related sepsis. We hypothesized that PD-1/PDL1 interactions contribute to immune dysfunction after burn injury. To determine the impact of burn injury and infection on PD-L1, PD-1 and costimulatory receptor expression by leukocytes and its relationship to T cell functions. The efficacy of anti-PD-L1 antibody was evaluated in a clinically relevant mouse model of burn injury and bacterial infection. Mice underwent 35% scald burn followed by Pseudomonas aeruginosa or Staphylococcus aureus infection on day 4 postburn. Anti-PD-L1 was administered on day 3 postburn. Numbers and phenotype of leukocytes, plasma cytokine concentrations, bacterial clearance, organ injury, and survival were assessed. Burn injury and infection with P. aeruginosa caused a significant upregulation of PD-L1 on myeloid cells, along with a decrease in T cell numbers and function, significant multiorgan injury, and decreased survival. Treatment with anti-PD-L1 antibody improved bacterial clearance, reduced organ injury, and enhanced survival during Pseudomonas burn wound infection. Furthermore, anti-PD-L1 effectively protected against multiorgan injury, and improved bacterial clearance and survival following systemic S. aureus infection after burn injury. Blockade of PD-1/PD-L1 interactions might represent a viable treatment to improve outcomes among critically ill burn-injured subjects and increased leukocyte PD-L1 expression could serve as a valuable biomarker to select appropriate patients for such treatment.
Yet more evidence that myelin protons can be directly imaged with UTE sequences on a clinical 3T scanner: Bicomponent analysis of native and deuterated ovine brain specimens
Authors: Fan Shu‐Juan , Ma Yajun , Zhu Yanchun , Searleman Adam , Szeverenyi Nikolaus M. , Bydder Graeme M. , Du Jiang 
Published: December 2017

PurposeUTE sequences with a minimal nominal TE of 8 µs have shown promise for direct imaging of myelin protons (T2, < 1 ms). However, there is still debate about the efficiency of 2D slice‐selective UTE sequences in exciting myelin protons because the half excitation pulses used in these sequences have a relatively long duration (e.g., 0.3–0.6 ms). Here, we compared UTE and inversion‐recovery (IR) UTE sequences used with either hard or half excitation pulses (durations 32 µs or 472 µs, respectively) for imaging myelin in native and deuterated ovine brain at 3T.MethodsFreshly frozen ovine brains were dissected into ∼2 mm‐thick pure white matter and ∼3 to 8 mm‐thick cerebral hemisphere specimens, which were imaged before and/or after different immersion time in deuterium oxide.ResultsBicomponent
analysis of UTE signals obtained with hard excitation pulses detected an ultrashort T2 component (STC) fraction (fS) of 0% to 10% in native specimens, and up to ∼86% in heavily deuterated specimens. fS values were significantly affected by the TIs used in IR‐UTE sequences with either hard or half excitation pulses in native specimens but not in heavily deuterated specimens. The STC
was in the range of 150 to 400 µs in all UTE and IR‐UTE measurements obtained with either hard or half excitation pulses.ConclusionOur results further support myelin protons as the major source of the ultrashort
signals seen on IR‐UTE images and demonstrate the potential of IR‐UTE sequences with half excitation pulses for directly imaging myelin using clinical scanners. Magn Reson Med 80:538–547, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
A prediction model‐based algorithm for computer‐assisted database screening of adverse drug reactions in the Netherlands
Authors: Scholl Joep H.G. , van Hunsel Florence P.A.M. , Hak Eelko , van Puijenbroek Eugène P. 
Published: December 2017

AbstractPurposeThe statistical screening of pharmacovigilance databases containing spontaneously reported adverse drug reactions (ADRs) is mainly based on disproportionality analysis. The aim of this study was to improve the efficiency of full database screening using a prediction model‐based approach.MethodsA logistic regression‐based prediction model containing 5 candidate predictors was developed and internally validated using the Summary of Product Characteristics as the gold standard for the outcome. All drug‐ADR associations, with the exception of those related to vaccines, with a minimum of 3 reports formed the training data for the model. Performance was based on the area under the receiver operating characteristic curve (AUC). Results were compared with the current method of database screening based on the number of previously analyzed associations.ResultsA total of 25 026 unique drug‐ADR associations formed the training data for the model. The final model contained all 5 candidate predictors (number of reports, disproportionality, reports from healthcare professionals, reports from marketing authorization holders, Naranjo score). The AUC for the full model was 0.740 (95% CI; 0.734–0.747). The internal validity was good based on the calibration curve and bootstrapping analysis (AUC after bootstrapping = 0.739). Compared with the old method, the AUC increased from 0.649 to 0.740, and the proportion of potential signals increased by approximately 50% (from 12.3% to 19.4%).ConclusionsA prediction model‐based approach can be a useful tool to create priority‐based listings for signal detection in databases consisting of spontaneous ADRs.
The effect of fibre sizing and compatibilizer of polypropylene/poly(butylene terephthalate) blends on the mechanical and interphase properties of basalt fibre reinforced composites
Authors: Ignaczak Wojciech , Sui XiaoMeng , Kellersztein Israel , Wagner Hanoch Daniel , El Fray Miroslawa 
Published: December 2017

AbstractThe effect of basalt fibre sizing on the mechanical and interphase properties of fibre‐reinforced composites was studied. Two different chemical preparations of the fibre surface (PBT‐compliant and PP‐compliant) were used. The polymer matrix was prepared from polypropylene/poly(butylene terephthalate) (PP/PBT) immiscible polymer blend and the effect of different compatibilizers on the composite properties was evaluated. SEM hints at improved fibre adhesion to the polymer matrix when a PP‐compliant sizing is applied. SEM also reveals improved compatibilization effects when block copolymer instead of multiblock copolymer is used for the PP/PBT blend preparation. The pull‐out test was applied to quantitatively evaluate the interface adhesion between the fibres and matrices. It showed a high value of the interfacial shear strength between basalt fibres modified with PP‐compliant sizing and polymer blend compatibilized by block copolymer, thus confirming good adhesion. One possible explanation of such good mechanical properties can be related to the chemical interactions between functional groups, mainly maleic anhydride on basalt fibres and the polyolefin component (PP) of the polymer matrix. © 2017 Society of Chemical Industry
Gel forming waterborne dispersion polymerization of sodium p‐styrene sulfonate with glycidyl methacrylate
Authors: Dsouza Roshan F. , Parthiban Anbanandam 
Published: December 2017

ABSTRACTWater soluble monomer like sodium p‐styrene sulfonate (SSS) is copolymerized with hydrophobic and reactive monomer glycidyl methacrylate (GMA). The polymerization proceeds as dispersion and forms gels. The gel forming nature prevails even with other hydrophobic and hydrophilic monomers to form ternary polymeric systems. The swelling is dependent on polymer composition as well as the treatment history of polymers. SSS also induces ring opening of GMA to form 1,2‐diols as confirmed independently by various model reactions. The ability of hydrogels to absorb various dyes indicates that owing to the anionic nature, hydrogels absorb cationic dyes nearly quantitatively. Because of their strong affinity to cationic species these hydrogel forming polymers are potentially useful in water purification applications as well as purification of proteins. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 626–634
NIR‐Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples
Authors: Li Chenxi , Shen Jianwei , Yang Jianfeng , Yan Jun , Yu Haijun , Liu Jian 
Published: December 2017

AbstractThere is a great challenge to overcome the limitation of tissue penetration depth, while maximizing the benefit of light‐triggered biochemical cascades in a well‐defined mode simultaneously. Here, a new method of near‐infrared (NIR) light‐triggered release of nitric oxide (NO) by developing upconversion nanoparticles (UCNPs)‐based conjugate chemistry is reported. As the key nanotransducer in the design, core–shell‐structured UCNPs are encapsulated with a layer of SiO2 and then covalently linked with a potent NO‐releasing donor (S‐nitroso‐N‐acetyl‐dl‐penicillamine, SNAP). It is featured with highly localized breakage of chemical bonds of SNAP molecules by NIR–UV upconversion, enabling simultaneous NO release in a light dosage‐dependent manner. The biological effects of NO releasing are demonstrated by cellular imaging and inhibition of platelet aggregation from blood samples. This work provides a flexible and robust platform to generate cell‐signaling gas molecules trigged by NIR laser with deep tissue penetration.
Pilomatrix carcinoma on the left temporal region: A case report and review of the literature
Authors: Lai Jun‐Ming , Luo Hui , Hu Shuang , Lin Hong 
Published: December 2017

AbstractPilomatrix carcinoma is a very rare malignant tumor. The present article raises awareness of the clinical features, diagnosis, and treatment of this malignancy. The clinical data of a case of pilomatrix carcinoma of the left temporal region treated at the First Affiliated Hospital of Nan Chang University, Nan Chang, China, in April 2017 were analyzed retrospectively, and the related literature was reviewed. The patient underwent a wide excision of the mass, and microscopic examination revealed that the tumor showed the typical features of pilomatrix carcinoma. Pilomatrix carcinoma is a very rare tumor with approximately 130 cases reported in the English literature. An optimal treatment regimen has not been established; however, wide surgical excision is recommended to avoid recurrence when the staging shows no metastasis, and adjuvant radiotherapy might be beneficial for local tumor control. Pilomatrix carcinoma is considered to be a low‐grade malignant tumor and shows an aggressive growth pattern. A wide surgical excision and radiotherapy are the main modalities of treatment.
New Antimicrobial Leads in Phenothiazine Scaffold: Synthesis, Biological Assay and Virtual Screening
Authors: Onoabedje Efeturi A. , Ibezim Akachukwu , Onoabedje Ufuoma S. , Egu Samuel A. , Okoro Uchechukwu C. 
Published: December 2017

AbstractA variety of 2‐substituted 10H‐phenothiazine were synthesized via palladium catalyzed cross‐coupling reactions and showed good activity against bacillus cereus, staphylococcus aureus, escherichia coli, pseudomonas aeruginosa bacteria. Particularly, thiophenyl and furanyl derivatives exhibited broad spectrum of activities over phenyl, styryl, alkynyl and arynyl derivatized compounds. In addition, virtual screening revealed that all the phenothiazines stopped the activity of NMT at concentrations ranging from 147.00 nM to 9.11 μM. Two derivatives, 2‐phenyl‐10H‐phenothiazine and 2‐styryl‐10H‐phenothiazine, were identified as novel inhibitors of two validated antimicrobial drug targets (peptide deformylase and N‐myristoyl transferase) according to theoretical binding free energy calculations.
C/Sn/RGO Nanocomposites as Higher Initial Coulombic Efficiency Anode for Sodium‐Ion Batteries
Authors: Dong Wei , Yang Shaobin , Liang Bing , Shen Ding , Sun Wen , Liu Yue , Zhao Yisong , Wang Xuelei , Wu Xiulin 
Published: December 2017

AbstractTheoretically, metal Sn owns higher initial coulombic efficiency than SnO2 in the sodium‐ion batteries (SIBs). Metal Sn is commonly obtained by the thermal reduction of SnO2 at present. However, the uncontrollable growth of metal Sn particles during the reduction progress is a key challenge. In this work, a composite material of refined metal Sn particles (particle size about 20∼200 nm) and carbon buffer medium has been prepared by a novel method, which is simple thermal reduction adopted after the treatment of SnO2/RGO in the pitch kerosene solution. The results show that this method overcomes the uncontrollable growth of metal Sn particles. Electrochemical tests show that C/Sn/RGO possesses a higher initial reversible capacity of 476.2 mAh g−1, and a higher initial coulombic efficiency of 70.3%. This method would have wider applications for the attractive properties of Na‐ion batteries in the future.
Hierarchical Polyaniline‐MnO2‐Reduced Graphene Oxide Ternary Nanostructures with Whiskers‐Like Polyaniline for Supercapacitor Application
Authors: Khawas Koomkoom , Kumari Pallavi , Daripa Soumili , Oraon Ramesh , Kuila Biplab Kumar 
Published: December 2017

AbstractHere, we have demonstrated a straight forward and easy synthetic route for preparation of three dimensional hierarchical and porous polyaniline (PANI)/manganese dioxide (MnO2)/reduced graphene oxide (rGO) ternary hybrid nanomaterials with surface decorated by ordered PANI whiskers. The nanostructured material shows different well defined morphology like tubular fiber, sphere which resembles natural tubular wiregrass sedge and spherical cactus. The simple removal of graphene surface modifier through selective dissolution from nanohybrids results further porous structure. The ternary hybrid materials show varying capacitance values depending on composition and nanostructured morphology with the best capacitance value of 762 F/g at current density 1.4 A/g with good electrochemical stability.
Synthesis of a Square [5]Catenane by Simple Amine‐Aldehyde Condensation
Authors: Shen Yenan , Zhou Qianwen , Zou Lei , Wang Qiaochun 
Published: December 2017

AbstractUsing the Schiff base formation reaction, a linear centrally cucurbit[7]uril(CB[7])‐encircled [2]peseudorotaxane with aldehyde groups on both ends was condensed with a 90°carbazole 3,6‐diamine to generate a square [5]catenane, featured by four equal [2]rotaxanes at each side, demonstrating an effective way to integrate interlocked molecules in order.
Agro‐Industrial Waste Based Phycocyanin Production from Oscillatoria sp. 50 A: daf‐16 Modulating Effect in Caenorhabditis elegans and p53 Dependent Apoptosis in HeLa cells
Authors: Jawaharraj Kalimuthu , Shivani Krishna , Shakambari Ganeshan , Sameer Kumar Rai , Ashokkumar Balasubramaniem , Varalakshmi Perumal 
Published: December 2017

AbstractCyanobacterial phycocyanin (C‐PC) has always been used in therapeutics and nutraceuticals. Herein we report, enhanced C‐PC production by Oscillatoria sp. 50 A through media optimization using response surface methodology (RSM) with two folds higher C‐PC yield (0.072 ± 0.001 mg/mL) in 30 days with optimized media containing 2.5 mL/L each of sugar industrial effluent (SE) and tannery effluent (TE) than normal BG‐11 medium. Moreover, C‐PC was successfully purified to homogeneity and characterized by FT‐IR, spectrofluorimetry and MALDI‐TOF peptide fingerprinting. The therapeutic efficacy of C‐PC was studied in vivo in hypercholesterol induced daf–16::GFP C. elegans, which evidenced prominent down‐regulation of daf‐16 (0.5 ± 0.2 fold) in C‐PC treated obese vs untreated obese worms. In another independent model study, the purified C‐PC exerted cytotoxicity in HeLa cells at IC50 value of 77.76 ± 2.41 μg/mL, which induced pro‐apoptotic p53 expression, indicating its potential implications as cancer therapeutic agent. Moreover, C‐PC does not induce any cytotoxicity or immune response on normal RAW 264.7 macrophage cells. Thus, the cost‐efficient way of hyper‐production of C‐PC from cyanobacteria Oscillatoria sp. 50 A can be achieved using agro‐industrial wastes such as SE and TE for versatile therapeutic applications in treatment of obesity and/or cancer.
Syntheses of Nitronium Salts: A New Strategy towards Solid Nitronium Monosulfates
Authors: Zelenov Victor P. , Bukalov Sergey S. , Leites Larissa A. , Bushmarinov Ivan S. , Struchkova Marina I. , Dmitrienko Artem O. , Tartakovsky Vladimir A. 
Published: December 2017

AbstractA new approach towards nitronium salts via the reaction of CF3COONO2 (TFAN) with acids was developed. This method was applied to the syntheses of the following solid nitronium salts: NO2HSO4 (1), NO2HS2O7 (2), (NO2)2S2O7 (3), (NO2)(CF3CO)SO4 (4), NO2ClO4 (5), (NO2)CF3SO3 (6), (NO2)FSO3 (7), NO2IO4 (8), (NO2)(CF3CO)S2O7 (9), and NO2BF4 (10) (71–95%). Nitronium monosulfates 1 and 4 as well as compounds 8, 9 and NO2HS3O10 (11) were obtained for the first time. The structures of compounds 3 and 4 were confirmed by powder X‐ray diffraction.
Reconsidering Asian American Student Development
Authors: Kodama Corinne M. , Maramba Dina C. 
Published: December 2017

AbstractThis chapter addresses the applicability of student development theories in light of empirical research on Asian American college students through a twofold approach: (a) revisiting the relevance of Kodama, McEwen, Liang, and Lee's (2001, 2002) theoretical work on Asian American student development; and (b) using Jones’ and Stewart's (2016) framework to complicate thinking on new paradigms for understanding and advancing student development theory and research.
Prevalence of internet addiction and its risk and protective factors in a representative sample of senior high school students in Taiwan
Authors: Lin Min‐Pei , Wu Jo Yung‐Wei , You Jianing , Hu Wei‐Hsuan , Yen Cheng‐Fang 
Published: December 2017

ABSTRACTThe aim of this study investigated the prevalence of Internet addiction (IA) in a large representative sample of secondary school students and identified the risk and protective factors. Using a crosssectional design, 2170 participants were recruited from senior high schools throughout Taiwan using both stratified and cluster sampling. The prevalence of IA was 17.4% (95% confidence interval, 15.8%–19.0%). High impulsivity, low refusal self‐efficacy of Internet use, high positive outcome expectancy of Internet use, high disapproving attitude of Internet use by others, depressive symptoms, low subjective well‐being, high frequency of others' invitation to Internet use, and high virtual social support was all independently predictive in the logistic regression analysis. The prevalence of IA among secondary school students in Taiwan was high. Results from this study can be used to help educational agencies and mental health organizations create policies and design programs that will help in the prevention of IA in adolescents.
Effect of Individualized Combined Exercise Versus Group-Based Maintenance Exercise in Patients With Heart Disease and Reduced Exercise Capacity
Authors: Christle Jeffrey W. , Schlumberger Anna , Zelger Otto , Haller Bernhard , Beckers Paul , Myers Jon , Halle Martin , Pressler Axel 
Published: December 2017

Purpose:
To compare individualized endurance + resistance exercises (ICE) with a traditional cardiac maintenance program (CMP) on exercise performance in patients with cardiac disease and low exercise capacity.

Methods:
Patients eligible for cardiac rehabilitation with peak exercise capacity <6 metabolic equivalents (METs) were randomly allocated to once-weekly ICE or CMP for 6 mo. ICE used 60 min of individualized moderate endurance and strength exercises. CMP used 60 min of group calisthenics plus relaxation and flexibility exercises. Maximal and submaximal endurance and strength exercise performance were assessed at baseline and 6 mo.

Results:
Seventy patients (70 ± 9 y; 38% female) were included in the intention-to-treat analyses. Large and significant improvements in both submaximal endurance and maximal strength were observed in the ICE group compared with the CMP group. Submaximal exercise duration (+111 ± 112 sec vs +14 ± 120 sec, P < .01), workload (+16 ± 16 W vs +2 ± 17 W, P < .01), and muscular strength (+7 ± 8 kg vs 0 ± 7 kg and +16 ± 14 kg vs 0.2 ± 12 kg for upper- and lower-body strength, P < .01) all favored ICE over CMP. No significant between-group differences were observed in peak exercise performance (+0.05 ± 0.17 W/kg vs +0.04 ± 0.17 W/kg, P = .83) or peak oxygen uptake (−0.1 ± 3.1 mL/kg/min vs +0.6 ± 3.2 mL/kg/min, P = .38).

Conclusions:
Patients with cardiac disease and low exercise capacity improved submaximal exercise performance and muscular strength with once-weekly ICE but not with CMP. Neither ICE nor CMP led to an improvement in peak exercise endurance performance. The implementation of ICE in this population would be feasible and may result in greater benefit for performing activities of daily living.
New developments in understanding focal cortical malformations
Authors: Becker Albert J. , Beck Heinz 
Published: December 2017

Purpose of review
Focal cortical dysplasias (FCDs) represent common cortical malformations that are frequently associated with epilepsy. They have so far not been well understood in terms of their molecular pathogenesis, and with respect to mechanisms of seizure emergence.

Recent findings
Several recent studies have succeeded in making significant advances in understanding the molecular genetics, in particular FCD type II. A second major advance has been the development of novel rodent models of FCDs that replicate a somatic mutation seen in humans, lead to a focal lesion, and recapitulate many phenotypic features of human FCDs. We will discuss these recent advances.

Summary
These advances promise significant advances in understanding the heterogeneity of FCDs at the molecular genetic level. They also promise a much better understanding of cell-intrinsic and network mechanisms underlying increased seizure susceptibility and altered cognition. Systematic studies utilizing the approaches summarized here promise to lead to specific strategies regarding when and how to treat specific subgroups of FCDs.