bluuebunny/crossref_metadata_2025_split huggingface dataset:
An alternate approach in exploring the causal link between financial development and economic growth—Evidence from advanced economies
Authors: Swamy Vighneswara , Dharani M 
Published: January 2018

AbstractThis study explores the causal link between financial development and economic growth in advanced economies as these countries experience significantly higher levels of financial development. Using a fully balanced panel of 24 economies from 1983 to 2013, the study shows that when imposing a linear relationship, the financial development and economic growth are negatively associated in the long run. The panel granger causality tests establish the bidirectional causality between the financial development variables with growth. Employing an alternate approach of moderated mediation effect framework, we notice that the association of financial development with economic growth is moderated by the negative impacts of inflation, interest rate, and population dependency; and the positive mediation effect of trade openness. The policy implication is that there is a need to rein in inflation and real interest rates and enhance trade openness to optimize the benefits of growing financial development on economic growth.
The role of Cdk5‐mediated Drp1 phosphorylation in Aβ1‐42 induced mitochondrial fission and neuronal apoptosis
Authors: Guo Miao‐Yu , Shang Lei , Hu Yang‐Yang , Jiang Li‐Ping , Wan Yu‐Ying , Zhou Qin‐Qin , Zhang Kun , Liao Hong‐Fei , Yi Jing‐Lin , Han Xiao‐Jian 
Published: January 2018

AbstractAlzheimer's disease, one of the most common neurodegenerative diseases, is pathologically characterized by Amyloid beta containing plaques and neurofibrillary tangles. Amyloid beta (Aβ) induces neuronal apoptosis through the intracellular Ca2+ increase, subsequent hyperactivation of cyclin‐dependent kinase 5 (Cdk5) and mitochondrial abnormality. Recently, Cdk5 was identified as an upstream regulator of mitochondrial fission during neuronal apoptosis, but the underlying mechanism remains unclear. Here, in vitro phosphorylation assays showed that Cdk5 could phosphorylate the recombinant Drp1 at Serine 579. Aβ1‐42 stimulation increased the phosphorylation level of Drp1 at Serine 579 in mouse cortical neurons. Cdk5 inhibitor roscovitine and knockdown of Cdk5 by a lentiviral vector expressing shRNA targeting Cdk5 (Lenti‐Cdk5‐shRNA) efficiently prevented Aβ1‐42 induced Drp1 phosphorylation in neurons. In addition, Aβ1‐42 stimulation induced markedly mitochondrial fission in neurons. Roscovitine, Lenti‐Cdk5‐shRNA and expression of phospho‐defect mutatant GFP‐Drp1‐S579A in neurons attenuated Aβ1‐42 induced mitochondrial fission, whereas expression of phospho‐mimetic mutant GFP‐Drp1‐S579D alone resulted in mitochondiral fission similar to Aβ1‐42 stimulation. Moreover, Roscovitine and Lenti‐Cdk5‐shRNA suppressed the cleavage of caspase‐3 and protected neurons against Aβ1‐42 induced neuronal apoptosis.Thus, our data indicate that Drp1 is a direct target of Cdk5, and Cdk5‐mediated phosphorylation of Drp1 at Serine 579 regulates Aβ1‐42 induced mitochondrial fission and neuronal toxicity.
Berberine demonstrates anti‐inflammatory properties in Helicobacter pylori‐infected mice with chronic gastritis by attenuating the Th17 response triggered by the B cell‐activating factor
Authors: Wu Xiuxia , Li Xian , Dang Zhongqin , Jia Yunfei 
Published: January 2018

AbstractBerberine (BBR) is an isoquinoline alkaloid derived from various medicinal herbs. Previous studies have suggested that BBR exerts antimicrobial, antitumor, and antidiabetic effects and can be used to treat Helicobacter pylori‐induced chronic gastritis. However, the exact mechanism by which BBR inhibits H. pylori infection is not fully understood. We investigated the anti‐inflammatory properties and potential mechanism of BBR in H. pylori‐infected mice with chronic gastritis. We found that BBR can suppress the expression of pro‐inflammatory genes IL‐6, TGF‐β, and IL‐1β and upregulate anti‐inflammatory gene IL‐10 expression in the mucosa and RAW 264.7 macrophages. Exposure to BBR also reduced the expression and accumulation of IL‐17 in the mucosa and CD4+ T cells activated by anti‐CD3 and anti‐CD28, and it decreased the frequency of IL‐17‐producing CD4+ T cells. B cell‐activating factor (BAFF) production was inhibited by BBR and by cultured dendritic and CD4+ T cells. Furthermore, we demonstrated that BAFF can trigger the Th17 response by promoting the production of pro‐Th17 cytokines IL‐6, TGF‐β, and IL‐1β, which are strongly associated with the anti‐inflammatory role of BBR in chronic gastritis caused by H. pylori. In conclusion, we determined that BBR has anti‐inflammatory effects on H. pylori‐induced chronic gastritis by attenuating the BAFF‐triggered Th17 response.
Effects of Benzoapyrene on migration and invasion of lung cancer cells functioning by TNF‐α
Authors: Zhao Guangqiang , Wang Zhengxi , Huang Yunchao , Ye Lianhua , Yang Kaiyun , Huang Qiubo , Chen Xiaobo , Li Guangjian , Chen Ying , Wang Jinhui , Zhou Yongchun 
Published: January 2018

AbstractIn this study, we attempted to find out the underlying mechanism of Benzoapyrene and metastasis of lung cancer cells. We also did experiments to testify the connection between BaP and its potential target, TNF‐α. Cell median lethal dose (IC50) of both cells was measured by crystal violet method. Quantitative real‐time reverse transcription PCR (qRT‐PCR) and Western blot were employed to detect the expression of TNF‐α. Wound healing assay and transwell assay were utilized to testify the impacts of BaP and TNF‐α on the metastasis of lung cancer cells. Cell death rate was elevated with the increase of BaP concentration. BaP increased the number of metastatic cells of lung cancer. The expressions of TNF‐α pathway‐associated protein (TNF‐α, NF‐kB [P65], Caspase3, and Caspase8) were enhanced by overexpressed BaP. TNF‐α shRNA suppressed the positive effects of BaP on migration and invasion of lung cancer cells. Our study validated the positive effects of BaP on the metastasis of lung cancer cells. We also revealed the instrumental role of TNF‐α in helping the development of lung cancer cells induced by BaP.
HipOP mesenchymal population has high potential for repairing injured peripheral nerves
Authors: Yamauchi Yukako , Itoh Shousaku , Naruse Haruna , Itoh Yuki , Abe Makoto , Kagioka Takumi , Hayashi Mikako 
Published: January 2018

AbstractBone marrow stromal cells (BMSCs) are reportedly a heterogeneous population of mesenchymal stem cells (MSCs). Recently, we developed a simple strategy for the enrichment of MSCs with the capacity to differentiate into osteoblasts, chondrocytes, and adipocytes. On transplantation, the progenitor‐enriched fractions can regenerate the bone with multiple lineages of donor origin and are thus called “highly purified osteoprogenitors” (HipOPs). Although our previous studies have demonstrated that HipOPs are enriched with MSCs and exhibit a higher potential to differentiate into osteoblasts, adipocytes, and chondrocytes than BMSCs, their potential to differentiate into neural cells has not been clarified. In this study, we evaluated the efficacy of HipOPs as a resource of neural stem cells. The neurosphere assay showed that neurospheres formed by HipOPs exhibited self‐renewal ability and their size was generally larger than that of neurospheres formed by BMSCs. A limiting dilution assay was used to evaluate the frequency of neural progenitors in BMSCs and HipOPs. The results demonstrated that the frequency of neural progenitors in HipOPs was 120‐fold higher than that in BMSCs. Furthermore, to investigate the in vivo regenerative potential of the peripheral nerve, we modified a murine peripheral nerve injury experimental model and demonstrated that HipOPs exhibit a higher efficacy in repairing injured peripheral nerves. These findings suggest that HipOPs are a useful cell resource for regenerative therapies such as that in case of peripheral nerve injury.
Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells
Authors: Damiano Sara , Montagnaro Serena , Puzio Maria V. , Severino Lorella , Pagnini Ugo , Barbarino Marcella , Cesari Daniele , Giordano Antonio , Florio Salvatore , Ciarcia Roberto 
Published: January 2018

AbstractIn clinical practice for the treatment of chronic myeloid leukemia, second generation of tyrosine kinase inhibitors such as Nilotinib (NIL) specific and potent inhibitor of the BCR/ABL kinase and Dasatinib (DAS) a inhibitor of BCR/ABL and Src family kinase were developed to clinically overcome imatinib resistance. In this study, we wanted to test the ability of some antioxidants such Resveratrol (RES) or a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) or δ‐tocotrienol (δ‐TOCO) to interact with DAS and NIL on viability, reactive oxygen species (ROS) production, lipid peroxidation, and apoptosis. To test the possible mechanisms of action of such antioxidants, we utilized N‐acetyl‐L‐cysteine (NAC) a specific inhibitor ROS production or PP1 a specific Src tyrosine kinase inhibitor or BAPTA a specific chelator of intracellular calcium. Our data demonstrated: 1) RES, rMnSOD, δ‐TOCO, and NAC, at dose used, significantly reduced the intracellular levels of MDA induced by DAS or NIL; 2) RES, rMnSOD, and δ‐TOCO increased the intracellular ROS levels; 3) The increase ROS levels is related to higher levels of oligonucleosomesi induced by DAS and NIL and that NAC significantly reduced this activity. Interestingly, our data showed that apoptotic activity of DAS and NIL have significantly increased the production of oligonucleosomes by triggering excessive ROS generation as well as functionality of SERCA receptors.
Enclosings of decompositions of complete multigraphs in 2‐factorizations
Authors: Feghali Carl , Johnson Matthew 
Published: January 2018

AbstractLet k, m, n, λ, and μ be positive integers. A decomposition of into edge‐disjoint subgraphs is said to be enclosed by a decomposition of into edge‐disjoint subgraphs if and, after a suitable labeling of the vertices in both graphs, is a subgraph of and is a subgraph of for all . In this paper, we continue the study of enclosings of given decompositions by decompositions that consist of spanning subgraphs. A decomposition of a graph is a 2‐factorization if each subgraph is 2‐regular and spanning, and is Hamiltonian if each subgraph is a Hamiltonian cycle. We give necessary and sufficient conditions for the existence of a 2‐factorization of that encloses a given decomposition of whenever and . We also give necessary and sufficient conditions for the existence of a Hamiltonian decomposition of that encloses a given decomposition of whenever and either or and , or , , and .
Dentin bond strength and nanoleakage of the adhesive interface after intracoronal bleaching
Authors: Cavalli Vanessa , Sebold Maicon , Shinohara Mirela Sanae , Pereira Patrícia Nóbrega Rodrigues , Giannini Marcelo 
Published: January 2018

AbstractThis study evaluated dentin bond strength (BS) and nanoleakage of non‐ and pre‐etched dentin immediately (T0,), 7 days (T7), and 14 days (T14) after bleaching. Bovine incisors (150) were selected and half of them submitted to intrapulpal dentin etching (e). Non‐ and pre‐etched dentin were subjected to the following (n = 15): no bleaching/control (C); 35% carbamide peroxide (CP); 35% hydrogen peroxide (35% HP); 25% hydrogen peroxide (25% HP); and sodium perborate (SP). Bleaching agents were applied to the pulp chamber four times within a 72‐h interval. Afterwards, pulp chamber dentin was prepared for the BS test at different evaluation times (n = 5): T0, T7, and T14. Composite blocks were built on pulp chamber and sectioned in slices. Slices were reduced to an hour‐glass shape with a cross‐sectional area of 0.8 mm2 and submitted to microtensile BS test. Two additional specimens for each group were prepared for nanoleakage evaluation by transmission electron microscopy (TEM). Results were analyzed by ANOVA (two‐way) and Dunnett's test (p < .05). BS decreased immediately after intracoronal bleaching for both sound and pre‐etched dentin (p < .05). At T14, the BS of non‐etched bleached dentin increased for all groups, whereas the pre‐etched SPe group presented BS similar to the Ce. Nanoleakage within the hybrid layer was perceptible immediately after bleaching, although a decrease in nanoleakage was observed for all groups at T14. Adhesive restorations should be performed 7–14 days after bleaching, according to the bleaching agent used. Intracoronal bleaching should be performed preferably with sodium perborate if previous dentin etching is applied.
Extracellular matrix and traumatic brain injury
Authors: George Naijil , Geller Herbert M. 
Published: January 2018

AbstractThe brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell‐cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.
How to best address spatial and temporal variability of soil‐derived nitrous oxide and methane emissions
Authors: Jungkunst Hermann F. , Meurer Katharina H. E. , Jurasinski Gerald , Niehaus Engelbert , Günther Anke 
Published: January 2018

AbstractTake Home Message
It can be justifiable to determine nitrous oxide and methane flux rates from soil with only two concentration measurements to allow for more spatial precision.
Rapid differentiation of Chinese hop varieties (Humulus lupulus) using volatile fingerprinting by HS‐SPME‐GC–MS combined with multivariate statistical analysis
Authors: Liu Zechang , Wang Liping , Liu Yumei 
Published: January 2018

AbstractBACKGROUNDHops impart flavor to beer, with the volatile components characterizing the various hop varieties and qualities. Fingerprinting, especially flavor fingerprinting, is often used to identify ‘flavor products’ because inconsistencies in the description of flavor may lead to an incorrect definition of beer quality. Compared to flavor fingerprinting, volatile fingerprinting is simpler and easier.RESULTSWe performed volatile fingerprinting using head space‐solid phase micro‐extraction gas chromatography–mass spectrometry combined with similarity analysis and principal component analysis (PCA) for evaluating and distinguishing between three major Chinese hops. Eighty‐four volatiles were identified, which were classified into seven categories. Volatile fingerprinting based on similarity analysis did not yield any obvious result. By contrast, hop varieties and qualities were identified using volatile fingerprinting based on PCA. The potential variables explained the variance in the three hop varieties. In addition, the dendrogram and principal component score plot described the differences and classifications of hops.CONCLUSIONVolatile fingerprinting plus multivariate statistical analysis can rapidly differentiate between the different varieties and qualities of the three major Chinese hops. Furthermore, this method can be used as a reference in other fields. © 2018 Society of Chemical Industry
Flavour‐active compounds in thermally treated yeast extracts
Authors: Alim Aygul , Song Huanlu , Liu Ye , Zou Tingting , Zhang Yu , Zhang Songpei 
Published: January 2018

AbstractBACKGROUNDAroma‐active compounds and non‐volatile substances determine the characteristic aroma and taste of yeast extract (YE). Changes in the characteristic aroma and taste of YE due to thermal reaction are rarely studied, and the relationship between aroma‐active compounds and non‐volatile compounds is not yet clear.RESULTSNon‐volatile compounds identified by HPLC and LC/MS/MS were reduced by a rise in temperature, except for some amino acids. Peptides underwent degradation. In addition, a further rise in temperature above 120 °C resulted in a bitter and sour taste. Furans, pyrazines, thiophenes, thiazoles and some branched chain sulfur compounds were derived from GC/O/MS (SPME and SAFE). Sensory results revealed that the concentration of volatile compounds increased with an increase in temperature. The overall aroma profiles of YE at 25, 100 and 110 °C were buttery, green, nutty and meaty, while YE at 140 °C had a strong sour and sulfur odour.CONCLUSIONThe non‐volatile compounds of YE were reduced and different volatile compounds were produced under different thermal treatments. There was a negative correlation between these two types of compounds. The different taste sensors and all precursors were correlated with each other. There are significant relationships between different odorants and aroma‐active compounds of YE after thermal treatment. © 2018 Society of Chemical Industry
Protective effects of new antioxidant compositions of 4‐methylcoumarins and related compounds with dl‐α‐tocopherol and l‐ascorbic acid
Authors: Kancheva Vessela D , Slavova‐Kazakova Adriana K , Angelova Silvia E , Kumar Prashant , Malhotra Shashwat , Singh Brajendra K , Saso Luciano , Prasad Ashok K , Parmar Virinder S 
Published: January 2018

AbstractBACKGROUNDCoumarin derivatives possess a wide range of biological activities. By functionalization of the parent coumarin skeleton that has neither antioxidant nor biological activity, a series of new bio‐antioxidants has been designed.RESULTSNew antioxidant compositions (equimolar binary and ternary mixtures) of eight 4‐methylcoumarins and three related compounds have been tested and different effects between individual components have been observed: synergism (positive effect), additivism (summary effect) and antagonism (negative effect). Higher oxidative stability of the lipid substrate was obtained in the presence of the new antioxidant compositions of the studied compounds with dl‐α‐tocopherol and l‐ascorbic acid. The role of each component in the antioxidant compositions of ternary mixtures has been identified by using new equations composed by the authors.CONCLUSIONAll ternary mixtures demonstrate synergism as a result of continuous regeneration of dl‐α‐tocopherol from the studied antioxidants and l‐ascorbic acid. Theoretical calculations have been probed as indicators of the expected effects between the individual components in a binary mixture. © 2018 Society of Chemical Industry
Early assessment of post‐surgical outcomes with pre‐pectoral breast reconstruction: A literature review and meta‐analysis
Authors: Chatterjee Abhishek , Nahabedian Maurice Y. , Gabriel Allen , Macarios David , Parekh Mousam , Wang Fang , Griffin Leah , Sigalove Steven 
Published: January 2018

BackgroundPre‐pectoral breast reconstruction is an emerging surgical approach. This study provides an early assessment of outcomes with the technique.MethodsA comprehensive literature review was performed through searches of PubMed®/MEDLINE® to identify studies on pre‐pectoral reconstruction. Patient characteristics and outcomes were extracted from studies and pooled. Linear relationships between complication rates and patient characteristics with pre‐pectoral reconstruction were analyzed. A meta‐analysis compared complication rates between pre‐pectoral and dual‐plane reconstruction.ResultsFourteen studies (406 women/654 breasts) were included. The most common complications with pre‐pectoral reconstruction were flap necrosis (7.8%), seroma (6.7%), capsular contracture (5.8%), and explantation (4.6%). No hyperanimation was reported. Significant correlation between previous radiation and flap necrosis, post‐operative chemotherapy and infection, hypertension and flap necrosis, diabetes and dehiscence, and smoking and explantation were found. A meta‐analysis of four studies comparing pre‐pectoral (135 women/219 breasts) and dual‐plane (230/408) reconstruction found no significant difference for likelihood of infection (odds ratio, 0.46; 95% confidence interval, 0.16‐1.30), explantation (0.83; 0.29‐2.38), necrosis (1.61; 0.77‐3.36), seroma (1.88; 0.71‐5.02), dehiscence (1.84; 0.68‐4.95), or capsular contracture (0.14; 0.02‐1.14).ConclusionsComplication rates are comparable following pre‐pectoral and dual‐plane reconstruction, indicating the pre‐pectoral technique may be a feasible option for appropriate patients.
The secrets of failing better: Accessible publishing at SAGE. A case study
Authors: Manis Caroline , Alexander Huw 
Published: January 2018

Key points
Accessibility is often misunderstood as a concept that is niche or of secondary importance.
Reframing accessibility as improving the overall user experience instantly changes the perspective; accessibility becomes a critical requirement worthy of investment and resources.
The single most prevalent complaint amongst librarians is the time it takes to get hold of accessible content.
An accessibility roadmap provides structure and transparency for digital accessibility projects within the organization.
Publishers' non‐compliance with accessibility standards will increase their risk of sales declines and legal complications over time.
The SAGE A.C.C.E.S.S.I.B.L.E mnemonic offers suggestions on how to devise a successful accessible publishing programme.
Towards universal accessibility: The UK policy landscape and supporting technology
Authors: House Emma , Orme Richard , Bide Mark 
Published: January 2018

Key points
The UK policy landscape supports access for the users whilst allowing publishers to maintain business models.
Advancements such as EPUB 3, aligning publishing with web technologies, and the Inclusive Publishing hub help publishers reach accessibility compliance.
Print impairment is not an on/off switch, and each reader has his or her own unique set of requirements – a fact that is supported by EPUB 3.
The time is ripe for publishers to make firm commitments to accessibility initiatives.
An overview of content accessibility issues experienced by educational publishers
Authors: Bowes Frederick 
Published: January 2018

Key points
Educational accessibility needs to accommodate not only text but also supplemental, multimedia, and interactive elements.
Accessibility considerations need to address user needs for timeliness, quality, cost, and security.
Schools often default to remediation instead of embracing EPUB 3 for practical reasons and to respond to student preferences.
PDF is often preferred over EPUB for creating alternate formats because of familiarity and expediency.
Schools require accessibility to deal with increased legal pressure from both government agencies and disability advocates.
Do you have a broken link in your accessibility chain?
Authors: Kerscher George 
Published: January 2018

Key points
Accessibility of publications in academia is a non‐negotiable legal requirement.
The accessibility of your journal or other scholarly publication is the most important design consideration in your workflow.
EPUB Accessibility 1.0 and Web Content Accessibility Guidelines 2.0 provide a clear publishing pathway.
Consider the readability chain: Any link can result in accessibility failure but an unbroken chain will benefit all readers.