bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective evaluation of toceranib phosphate (Palladia) use in cats with mast cell neoplasia
Authors: Berger Erika P , Johannes Chad M , Post Gerald S , Rothchild Gillian , Shiu Kai-Biu , Wetzel Sarah , Fox Leslie E 
Published: March 2017

Objectives The purpose of this study was to solicit and compile data from practicing veterinary specialists regarding their use of toceranib in cats with mast cell neoplasia and to provide initial assessment of possible clinical benefit and adverse events. Methods The American College of Veterinary Internal Medicine and Oncology listservs were used to solicit data pertaining to cases in which toceranib was used in the treatment of feline mast cell neoplasia. Cases were included if the following data were received: signalment (age, sex, breed), diagnosis of mast cell neoplasia by either cytology or histopathology, anatomic classification of disease (cutaneous, splenic/hepatic, gastrointestinal, other), previous and concurrent treatment, toceranib dose (mg/kg) and schedule, duration of therapy, best response and documentation of adverse events. Results Case data from 50 cats with cutaneous (n = 22), splenic/hepatic (visceral) (n = 10), gastrointestinal (n = 17) or other (n = 1) mast cell neoplasia were received. Clinical benefit was seen in 80% (40/50), including 86% (19/22) with cutaneous, 80% (8/10) with visceral and 76% (13/17) with gastrointestinal involvement. A majority of cats (n = 35) received glucocorticoids during toceranib treatment. Median duration of treatment in cats experiencing clinical benefit was 36 weeks (range 4–106 weeks), 48 weeks (range 12–199 weeks) and 23 weeks (range 13-81 weeks) for cutaneous, visceral and gastrointestinal cases, respectively. Toceranib was administered at a median dose of 2.5 mg/kg (range 1.6–3.5 mg/kg); in 90% (45/50) the drug was given three times per week. Treatment was generally well tolerated with 60% (30/50) of cats experiencing adverse events. The majority of these events were low-grade (grade 1 or 2) gastrointestinal or hematologic events that resolved with treatment break and/or dose adjustment. Conclusions and relevance Toceranib appears to be well tolerated in feline patients with mast cell neoplasia. Biologic activity of this drug is evident in the studied cats; however, further prospective studies are needed to elucidate fully its role in treatment of this disease.
Prognostic Value of Her2/neu Expression in Gastrointestinal Stromal Tumors: Immunohistochemical Study
Authors: Abd El-Aziz Ahmed M , Ibrahim Eman A , Abd-Elmoghny Ashraf , El-Bassiouny Mohammed , Laban Zina M , Saad El-Din Somaia A , Shohdy Youhanna 
Published: March 2017

Background:Gastrointestinal stromal tumor (GIST) is a relatively rare type of neoplasms. In Egypt, it represents 2.5% of gastrointestinal tumors and 0.3% of all malignancies. Most of the GISTs develop in the stomach.Aim:To reveal the significance of Her2/neu immunohistochemical expression in GIST and its correlation with other histopathologic parameters and tumor relapse after regular follow-up.Patients and methods:This study is a retrospective and prospective cohort. It included 32 patients with GISTs, who were resectable with no distant metastasis. Immunohistochemical staining by Her2/neu was performed after complete surgical resection of the tumors with preservation of the pseudocapsule.Results:In total, 53.1% of cases were men and 46.9% women. Tumors were classified into low-risk (25%), intermediate-risk (21.9%), and high-risk groups (53.1%). Her2/neu expression was negative in 56.3% of GISTs and positive in 43.7%. Its expression was significantly correlated with risk grade ( P = .04), tumor size ( P = .001), mitotic count ( P = .00), and increased risk of relapse ( P = .00). Furthermore, tumor relapse was significantly correlated with the tumor mitotic counts ( P = .00). Using kappa agreement test, it showed that 4 mitotic counts/50 high-power fields (HPF) was the cutoff value with which the tumor might be associated more with relapse, with 83% sensitivity, 70% specificity, and P value of .003.Conclusions:Her2/neu might be used as an independent prognostic marker for tumor recurrence after complete resection of GIST, and the cutoff value of mitotic count that might predict tumor relapse is 4/50 HPF. However, more clinical studies with greater number of cases with fluorescent in situ hybridization integration are recommended.
Preoperative Serum Carcinoembryonic Antigen as a Marker for Predicting the Outcome of Three Cancers
Authors: Nan Jingzhu , Li Juan , Li Xiujuan , Guo Guanghong , Wen Xinyu , Tian Yaping 
Published: March 2017

Background: Serum levels of carcinoembryonic antigen (CEA) are associated with a variety of tumors. Objective: This study evaluated the prognostic value of pretreatment serum CEA levels in predicting the outcomes of multiple tumors subjected to treatment. Methods: Prior to therapy, serum samples from 71 prostate, 46 breast, 77 gastric, and 31 pancreatic cancer patients were collected to examine serum CEA levels. The cutoff value for CEA was set as determined by the maximum Youden index. The data were analyzed by the Kaplan-Meier curves generated by the log-rank test and Cox multivariate analysis. Results: The overall survival rate for all the patients was 71.11%. The 3-year survival rate of patients with prostate, breast, gastric, and pancreatic cancers was 81.69%, 95.65%, 54.55%, and 51.61%, respectively. The 3-year survival rate showed significant statistical differences between patients with serum CEA levels <2.885 µg/L and those with serum CEA levels ⩾2.885 µg/L ( P < .001). The statistical differences of the 3-year survival rate also existed in the men ( P = .010) or women group ( P < .001), as well as in the 3 different types of cancer, which include breast cancer ( P = .025), gastric cancer ( P = .001), and pancreatic cancer ( P = .047). Conclusions: Serum CEA levels can provide additional prognostic information and may be useful in treatment implementation for patients with breast, gastric, or pancreatic cancer.
Effects of Serum Leptin and Resistin Levels on Cancer Cachexia in Patients With Advanced-Stage Non–Small Cell Lung Cancer
Authors: Demiray Gökcen , Değirmencioğlu Serkan , Uğurlu Erhan , Yaren Arzu 
Published: March 2017

Introduction: Cancer cachexia is one of the most frequent effects of malignancy, is often associated with poor prognosis, and may account for up to 20% of cancer deaths. The aim of our study was to evaluate the relationship of cancer cachexia and serum levels of resistin and leptin in patients with advanced non–small cell lung cancer. Methods: A total of 67 chemotherapy-naïve patients with advanced-stage non–small cell cancer and a control group containing 20 healthy individuals without a known chronic disease were enrolled in this study. All individuals in the control group were age and sex matched. Demographic, anthropometric, laboratory data and serum levels of adipokines were measured for 2 groups. Progression-free survival and overall survival were estimated using the Kaplan-Meier method. Survival among various factors was calculated using the log-rank test. Results: Patients presented significantly higher serum resistin ( P = .0001) and lower serum leptin levels ( P = .025) than the control group. Lower serum levels of leptin were correlated with overall survival ( P = .011). Conclusions: Serum leptin and resistin levels play key role as proinflammatory cytokines in lung cancer and cancer cachexia; however, their use as diagnostic or prognostic markers is not possible yet, and further large-scale studies are required to confirm our findings.
Association of statins with aortic, peripheral, and visceral artery aneurysm development
Authors: Mansi Ishak A , Frei Christopher R , Halm Ethan A , Mortensen Eric M 
Published: March 2017

Objectives Prior studies examining the effects of statins on arterial aneurysm development and progression yielded conflicting results due to their smaller size and presence of residual confounders. The objective of this study is to examine the association of statins with risk of being diagnosed with aortic, peripheral, and visceral artery aneurysm. Methods This was a retrospective cohort study of Tricare enrollees (from 1 October 2003 to 31 March 2012). Main outcomes were diagnosis of aortic, peripheral, or visceral artery aneurysm and undergoing aortic aneurysm repair procedure during follow-up period. Using 115 baseline characteristics, we generated a propensity score to match statin users and nonusers and examine the odds of outcomes (primary analysis). Secondary analysis examined outcomes at various subcohorts. Results Out of 10,910 statin users and 49,545 nonusers, we propensity score-matched 6728 pairs of statin users and nonusers. Statin users and nonusers had similar odds of being diagnosed with aortic, peripheral, and visceral artery aneurysms (odds ratio [OR]: 1.06, 95% confidence interval [95% CI]: 0.85–1.33) and of undergoing aortic aneurysm repair procedures (OR: 0.54, 95% CI: 0.22–1.35). Secondary analysis showed a tendency toward fewer aortic aneurysm procedures among statin users that did not reach statistical significance. However, high-intensity statin users in comparison to non-intensive statin users had higher adjusted odds of aortic, peripheral, and visceral artery aneurysms (OR: 1.76, 95% CI: 1.37–2.25, p < .0001). Conclusions This study does not support a clinically significant benefit or harm from statins regarding development of arterial aneurysm. However, secondary analyses may support the hypothesis proposed by previous research proposing a bidirectional role for statins.
The link between infant regulatory problems, temperament traits, maternal depressive symptoms and children’s psychopathological symptoms at age three: a longitudinal study in a German at-risk sample
Authors: Sidor Anna , Fischer Cristina , Cierpka Manfred 
Published: March 2017

AbstractBackgroundDifficult conditions during childhood can limit an individual’s development in many ways. Factors such as being raised in an at-risk family, child temperamental traits or maternal traits can potentially influence a child’s later behaviour. The present study investigated the extent of regulatory problems in 6-month-old infants and their link to temperamental traits and impact on externalizing and internalizing problems at 36 months. Moderating effects of maternal distress and maternal depressive symptoms were tested as well.MethodsIn a quasi-experimental, longitudinal study, a sample of 185 mother-infant dyads at psychosocial risk was investigated at 6 months with SFS (infants’ regulatory problems) and at 3 years with CBCL (children’s behavioural problems), EAS (children’s temperament), ADS (maternal depressive symptoms) and PSI-SF (maternal stress).ResultsA hierarchical regression analysis yielded a significant association between infants’ regulatory problems and both externalizing and internalizing behaviour problems at age 3 (accounting for 16% and 14% variance), with both externalizing and internalizing problems being linked to current maternal depressive symptoms (12 and 9% of the variance). Externalizing and internalizing problems were found to be related also to children’s temperamental difficulty (18 and 13% of variance) and their negative emotionality. With temperamental traits having been taken into account, only feeding problems at 6 months contributed near-significant to internalizing problems at 3 years.ConclusionsOur results underscore the crucial role of temperament in the path between early regulatory problems and subsequent behavioural difficulties. Children’s unfavourable temperamental predispositions such as negative emotionality and generally “difficult temperament” contributed substantially to both externalizing and internalizing behavioural problems in the high-risk sample. The decreased predictive power of regulatory problems following the inclusion of temperamental variables indicates a mediation effect of temperamental traits in the path between early regulatory problems and subsequent behavioural problems. Our results support the main effects of a child’s temperament, and to some degree maternal depressive symptoms, rather than the diathesis stress model of interaction between risky environment and temperamental traits.Trial registrationD10025651 (NZFH)
Open Online Courses in Public Health: experience from Peoples-uni
Authors: Heller Richard F. , Zurynski Robert , Barrett Alan , Oaiya Omo , Madhok Rajan 
Published: March 2017

Open Online Courses (OOCs) are offered by Peoples-uni at http://ooc.peoples-uni.org to complement the courses run on a separate site for academic credit at http://courses.peoples-uni.org. They provide a wide range of online learning resources beyond those usually found in credit bearing Public Health courses. They are self-paced, and students can enrol themselves at any time and utilise Open Educational Resources free of copyright restrictions. In the two years that courses have been running, 1174 students from 100 countries have registered and among the 1597 enrollments in 15 courses, 15% gained a certificate of completion. Easily accessible and appealing to a wide geographical and professional audience, OOCs have the potential to play a part in establishing global Public Health capacity building programmes.
Levels of metaphor
Authors: Kövecses Zoltán 
Published: March 2017

AbstractWhat is the appropriate conceptual structure involved in conceptual metaphors? Various authors offer a large number of terms to discuss the issue. While domain is the most common term, many others are also used, including frame, image schema, cognitive model, idealized cognitive model, scene, schema, scenario, etc. The problem is compounded by the fact that the terms mean different things to different researchers. The main goal of the paper is to create some clarity in this terminological and theoretical confusion. I propose that conceptual metaphors simultaneously involve conceptual structures, or units, on four levels of schematicity: the level of image schemas, the level of domains, the level of frames, and the level of mental spaces. I call the resulting framework the “multi-level view of conceptual metaphor.” The multi-level view of metaphor can provide us with insights into a number of problems that have been raised and debated in the CMT literature. I show that the study of metaphor within such a framework can legitimately be pursued on the four levels of schematicity and that no level can be singled out as the only appropriate level of analysis.
Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene
Authors: Lopez-Santillan Maria , Iparraguirre Leire , Martin-Guerrero Idoia , Gutierrez-Camino Angela , Garcia-Orad Africa 
Published: March 2017

Abstract
Acute lymphoblastic leukemia (ALL) is a major pediatric cancer in developed countries. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, hypersensitivity reactions are common. In those cases, discontinuation of treatment is usually needed and anti-asparaginase antibody production may also attenuate asparaginase activity, compromising its antileukemic effect. Till now, six pharmacogenetic studies have been performed in order to elucidate possible genetic predisposition for inter-individual differences in asparaginase hypersensitivity. In this review we have summarized the results of those studies which describe the involvement of four different genes, being polymorphisms in the glutamate receptor, ionotropic, AMPA 1 (GRIA1) the most frequently associated with asparaginase hypersensitivity. We also point to new approaches focusing on epigenetics that could be interesting for consideration in the near future.
Courier service quality from the clients’ perspective
Authors: Gulc Aleksandra 
Published: March 2017

Abstract
The aim of the study is a critical analysis of literature concerning the evaluation of courier service quality and verification if client expectations towards courier service quality change in time considering the perspective of future 5–10 years. Research methods include the theoretical analysis of scientific literature, CAWI survey and statistical analysis of obtained data.
The literature overview has shown the lack of clearly defined evaluation constructs of courier service quality together with the criteria and weight, one universal commonly used measuring scale for evaluation of the service quality, diversification of methods and measurement tools for the various groups of stakeholders of courier service. Moreover, it can be concluded that the research concerning the courier service quality has not considered the problem of aging of quality indicators. Research results by the author have proved that the expectations of clients using courier service change in time, some of them are exposed to the aging process (price) while others become more important (for example tele-technologies, modern packaging, and technical facilities). Moreover, the survey results have shown that the customer opinions can be the source of interesting and innovative ideas for the development of courier service in future.
The analysis of domestic and foreign literature allowed presenting the academia with an output concerning the evaluation of quality in the field of courier service. As a result, the theoretical and methodological gaps were revealed to expose potential fields for further research. The research results concerning different methods of service quality evaluation can be useful mainly for managers in courier enterprises. Moreover, the knowledge about changing expectations of clients allows adjusting courier proposals to customer needs to gain a competitive advantage in the global market.
Techniques for designing value propositions applicable to the concept of outcome-economy
Authors: Gierej Sylwia 
Published: March 2017

Abstract
The purpose of this article is to analyse and present some techniques that support the design of a value proposition in the context of the outcome-economy. The proposed techniques are intended to support traditional companies in the design of innovative solutions. Also, the discussed techniques were compared to identify the most effective. The study was conducted based on the information available in the literature on the impact of the Industrial Internet of Things on the economy and creation of a value proposition.
Browser-based Harnessing of Voluntary Computational Power
Authors: Fabisiak Tomasz , Danilecki Arkadiusz 
Published: March 2017

Abstract
Computers connected to internet represent an immense computing power, mostly unused by their owners. One way to utilize this public resource is via world wide web, where users can share their resources using nothing more except their browsers. We survey the techniques employing the idea of browser-based voluntary computing (BBVC), discuss their commonalities, recognize recurring problems and their solutions and finally we describe a prototype implementation aiming at efficient mining of voluntary-contributed computing power.
Kajian Perubahan Parameter Sensori dengan Metode Demerit Point Score pada Penurunan Kesegaran Ikan Patin Selama Pengesan
Authors: Ariyani Farida , Hermana Irma , Triwibowo Radestya , Wibowo Singgih 
Published: March 2017

Penelitian ini bertujuan untuk mempelajari perubahan parameter sensori pada penurunan kesegaran ikan patin (Pangasius hypopthalmus) selama pengesan menggunakan metode demerit point score (DPS). Percobaan dilakukan dengan mematikan ikan patin secara hypothermia, menyusunnya dalam kotak berinsulasi yang berisi es dengan perbandingan es : ikan = 2:1 (b/b), dan menyimpan kotak tersebut pada suhu ruang. Penggantian es yang mencair dilakukan setiap hari. Penurunan kesegaran ikan diamati secara sensori berdasarkan metode demerit point score (DPS) selama 25 hari dengan interval waktu pengamatan setiap 5 hari terhadap atribut kenampakan, mata, insang, perut, anus dan rongga perut menggunakan skala 0-3 untuk setiap parameter pada masing-masing atribut. Hasil kajian menunjukkan bahwa parameter utama yang menentukan perubahan sensori secara signifikan pada patin segar adalah kenampakan dan kekakuan pada atribut kenampakan umum, kejernihan dan bentuk pada atribut mata, warna dan bau pada atribut insang, bau pada atribut anus, dan stains pada atribut rongga perut. Adapun beberapa parameter yang relevansinya rendah terhadap penilaian panelis pada penurunan kesegaran patin antara lain lendir permukaan pada atribut kenampakan umum, darah pada atribut mata, lendir pada atribut insang, kekakuan dan diskolorasi pada atribut perut, dan kondisi pada atribut anus, sedangkan parameter kulit tidak memiliki relevansi terhadap penilaian panelis pada penurunan kesegaran patin. Berdasarkan penilaian panelis terhadap semua atribut, lama penyimpanan patin segar yang dinyatakan ditolak panelis adalah 25 hari.
ENTRELAÇOS DA FORMAÇÃO DOCENTE: VIVENCIANDO O COTIDIANO ESCOLAR ATRAVÉS DO PIBID
Authors: Araújo Edinaura Almeida de , Pereira Zildene Francisca , Dantas Nozângela Maria Rolim 
Published: March 2017

Resumo: A formação do professor iniciada nos cursos de graduação configura-se como o momento de definição, escolhas, envolvimento e aceitação da profissão. É também um período de reflexão e empoderamento do projeto educacional que congrega ações pedagógicas, metodológicas e culturais definidas e redefinidas em consonância com os contextos políticos, sociais, econômicos e culturais de cada região, cidade e/ou comunidade. O resultado das atividades está estritamente relacionada ao perfil do professor, que na sua ação cotidiana docente imprime as marcas de uma formação, princípios éticos e compromisso social adquiridos e/ou aperfeiçoados ao longo da vida acadêmica e da formação na vida em sociedade. O trabalho intitulado Entrelaços da formação docente: vivenciando o cotidiano escolar através do PIBID configura-se como uma reflexão acerca do Programa Institucional de Bolsas de Iniciação à Docência/PIBID, um projeto que promove a convivência e aprendizagem dos alunos no Centro de Formação de Professores da Universidade Federal de Campinha Grande - PB – CFP/UFCG - com escolas parceiras. Considerando a importância de conhecer o projeto traçou-se como objetivo reconhecer a importância do PIBID na formação do docente, aluno de graduação, refletir sobre a inovação estabelecida na formação a partir da iniciação à docência através das parcerias estabelecidas com escolas de Ensino Fundamental e Médio. No tocante à metodologia adotada, buscou-se a partir da pesquisa bibliográfica uma reflexão do subprojeto de Pedagogia, considerando a discussão da formação docente a partir luz dos teóricos: Alarcão (2003), Libâneo (2004), Guimarães (2005), Freitas (2007), Ferreira (2007), dentre outros. Palavras-chave: Formação docente. PIBID. Vivências escolares.