bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Quality Indicators to Address Abuse and Neglect in Home‐Based Primary Care and Palliative Care
Authors: Sheehan Orla C. , Ritchie Christine S. , Fathi Roya , Garrigues Sarah K. , Saliba Debra , Leff Bruce 
Published: October 2016

ObjectivesTo develop candidate quality indicators (QIs) for the quality standard of “addressing abuse and neglect” in the setting of home‐based medical care.DesignSystematic literature review of both the peer‐reviewed and gray literature.SettingHome‐based primary and palliative care practices.ParticipantsHomebound community‐dwelling older adults.MeasurementsArticles were identified to inform the development of candidate indicators of the quality by which home‐based primary and palliative care practices addressed abuse and neglect. The literature guided the development of patient‐level QIs and practice‐level quality standards. A technical expert panel (TEP) representing exemplary home‐based primary care and palliative care providers then participated in a modified Delphi process to assess the validity and feasibility of each measure and identify candidate QIs suitable for testing in the field.ResultsThe literature review yielded 4,371 titles and abstracts that were reviewed; 25 publications met final inclusion criteria and informed development of nine candidate QIs. The TEP rated all but one of the nine candidate indicators as having high validity and feasibility.ConclusionTranslating the complex problem of addressing abuse and neglect into QIs may ultimately serve to improve care delivered to vulnerable home‐limited adults who receive home‐based medical care.
Outcome of intracytoplasmic sperm injection using fresh and cryopreserved‐thawed testıcular spermatozoa in 83 azoospermic men with Klinefelter syndrome
Authors: Vicdan Kubilay , Akarsu Cem , Sözen Eran , Buluç Burcu , Vicdan Arzu , Yılmaz Yıldırım , Biberoğlu Kutay 
Published: October 2016

AbstractAimTo report the outcome of intracytoplasmic sperm injection (ICSI) cycles using fresh or cryopreserved‐thawed testicular spermatozoa of men with Klinefelter syndrome (KS).MethodsMedical records of 83 azoospermic men with KS who underwent testicular sperm extraction (TESE) were reviewed. The clinical parameters for predicting sperm retrieval and fertilization, implantation, pregnancy and live birth rates of ICSI cycles in these patients were evaluated.ResultsA total of 88 TESE procedures were performed with sperm retrieval rates of 39.8% per cycle (35/88) and 42.1% per patient (35/83). None of the studied clinical parameters were found to be informative in predicting successful sperm recovery. A total of 41 embryo transfer cycles were carried out using fresh testicular spermatozoa in 30, cryopreserved‐thawed spermatozoa in 10 and cryopreserved‐thawed embryo replacement in one. The fertilization and clinical pregnancy rates were comparable at 52.7% and 51.6% with fresh and 48.3% and 60% with cryopreserved‐thawed testicular spermatozoa groups, respectively. Twenty‐two clinical pregnancies were obtained, including 14 singletons, five twins, two triplets and one quadruplet and ended with the delivery of 13 singletons and six twins. In total, out of 25 delivered fetuses, four died (3 female, 1 male) following delivery and 21 newborns (14 female, 7 male) were healthy with a female to male ratio of 2:1. ConclusionsWe concluded that no clinical or laboratory parameter predicts the presence of spermatozoa in patients with KS, except the TESE procedure itself. The use of fresh or cryopreserved‐thawed spermatozoa on ICSI cycle outcomes are equally successful in patients with KS.
Impact of predators and competitors on the depth selection by two invasive gammarids
Authors: Kobak J. , Jermacz Ł. , Rutkowska D. , Pawłowska K. , Witkowska L. , Poznańska M. 
Published: October 2016

AbstractAppropriate habitat selection driven by multiple environmental cues may help organisms avoid predation pressure and excessive competition. Moreover, identification of habitat selection mechanisms of invasive organisms is crucial for predicting their distribution and impact in novel areas. We evaluated experimentally the habitat selection by Dikerogammarus villosus and Pontogammarus robustoides (Gammaroidea, Amphipoda, Crustacea), invasive in European fresh and brackish waters, with regard to depth, the presence of predators, the racer goby Babka gymnotrachelus, and heterospecific gammarid competitors. We exposed gammarids in single‐ and mixed‐species treatments in a 100‐cm‐long depth gradient (depth: 10–100 cm, levels every 10 cm) or in a control shallow tank (constant depth: 10 cm) in the presence or absence of predators located behind a mesh barrier adjacent to the deeper side of the gradient. Dikerogammarus villosus always selected deeper locations than P. robustoides. Both species did not affect each other's depth selection, but P. robustoides limited the distribution of D. villosus and pushed it towards the mesh barrier in the shallow tank. Dikerogammarus villosus responded to predators only in the depth gradient, retreating to shallower sites and climbing towards the surface. Pontogammarus robustoides moved away from the predator area in the shallow tank, indicating that its response was independent of depth selection. Thus, different depth distributions of both gammarids result from their specific preferences rather than from competitive displacement. The observed behaviour is likely to result in their segregation in the field, limiting inter‐specific competition, allowing for optimum utilization of resources and decreasing predatory pressure.
UBC18 mediates ERF1 degradation under light–dark cycles
Authors: Cheng Mei‐Chun , Kuo Wen‐Chieh , Wang Yi‐Ming , Chen Hsing‐Yu , Lin Tsan‐Piao 
Published: October 2016

Summary

Ethylene Response Factor 1 (ERF1) plays a crucial role in biotic and abiotic stress responses. Previous studies have shown that ERF1 regulates stress‐responsive gene expression by binding to different cis‐acting elements in response to various stress signals. ERF1 was also reported to be unstable in the dark, and it regulates hypocotyl elongation. Here, we elucidated the mechanism underlying degradation of ERF1.

Yeast two‐hybrid screening showed that UBIQUITIN‐CONJUGATING ENZYME 18 (UBC18) interacted with ERF1. The interaction between ERF1 and UBC18 was verified using pull‐down assays and coimmunoprecipitation analyses. We then compared the ERF1 protein abundance in the UBC18 mutant and overexpression plants. Based on the results of protein degradation and in vivo ubiquitination assays, we proposed that UBC18 mediates ERF1 ubiquitination and degradation.

ERF1 was more stable in UBC18 mutants and less stable in UBC18 overexpression lines compared with that in wild‐type plants. ERF1 was degraded by the 26S proteasome system via regulation of UBC18 and promotes dark‐repression of downstream genes and proline accumulation.

UBC18 negatively regulated drought and salt stress responses by altering the abundance of ERF1 and the expression of genes downstream of ERF1.
Maximum sustainable yield harvesting in an age‐structured fishery population model
Authors: Skonhoft Anders , Gong Peichen 
Published: October 2016

AbstractA generic type age‐structured fishery population model consisting of two harvestable age classes is formulated. Optimal harvest rates are determined with uniform fishing mortality and perfectly selective fishing, respectively. Selectivity allows for differentiating the fishing mortality among different age classes. Sustainable yield–biomass functions are developed, and the maximum sustainable yield (MSY) solutions are found under both exploitation schemes. The gain of perfectly selective fishing over uniform (or biomass) fishing is examined under various assumptions, and it is proved that the benefit of selective harvesting increases when the harvestable fish population becomes more heterogeneous in terms of weights, or values. In contrast to the surplus production model, or Clark model, the analysis also demonstrates that MSY with different age classes is not purely a biological concept.
Incidence of intraductal carcinoma, multifocality and bilateral significant disease in radical prostatectomy specimens from Japan and United States
Authors: Peng Yu‐Ching , Tsuzuki Toyonori , Kong Max Xiangtian , Li Jianhong , Deng Fang‐Ming , Melamed Jonathan , Zhou Ming 
Published: October 2016

AbstractSignificant differences, including epidemiologic, clinical, pathologic and genetic, exist between Asian and Caucasian prostate cancer. Detailed pathologic data are, however, scarce. We studied in detail and compared the pathological features of prostate cancer in radical prostatectomy specimens in 228 patients (117 Japan, 111 US). Japanese prostate cancer had a higher Gleason grade group (mean 2.67 vs. 2.42 US, P < 0.05), but lower pathological stage (72 % pT2 and 28 % pT3 vs 55 % pT2 and 45 % pT3 US, P < 0.05). Japanese cancer showed significantly more tumor foci (3.8 vs 2.9 US, P < 0.05), and higher incidence of bilateral significant disease (81.3 % vs. 66.7 % US, P < 0.05). The dominant tumor nodules in Japanese cases had higher Gleason grade group (mean 2.73 vs. 2.40 US, P < 0.05). The incidence of intraductal carcinoma was significantly higher in Japanese patients (35.3 % vs. 12.6 % US, P < 0.01), which was independent of Gleason score (7: 30.9 % Japan vs 11.8 % US, P < 0.01; ≥ 8: 87.5 % Japan vs 28.6 % US, P < 0.01) and tumor stage (pT2: 24.1 % Japan vs 6.6 % US, P < 0.01; pT3: 62.9 % Japan vs 20 % US, P < 0.01). These findings demonstrate distinct pathological features in prostate cancer between Japanese and Caucasian patients, and may have important diagnostic and therapeutic implications.
UTILISATION OF PLASTIC SACKS FIBRE AND BRAN ASH FOR SOFT CLAY SHEAR STRENGTH
Authors: Rika Putri Nyimas Septi , Dewi Ratna , Ilham Muhammad 
Published: October 2016

Soft soil possess poor mechanical properties, thus produce problems when bearing load. To overcome the problems, soft soil has to be stabilised. To do soil stabilisation, it Is imperative to add some mixture as additional substance in order to improve the characteristic of the soft soil. Plastic sacks fibre is one of the easily obtainable material which consists of high density profile, while bran ash contains good carbon and silica. This research aimed to determine the optimum level of plastic sacks waste fibre and bran ash to obtain the maximum soil shear strength and to compare the original soil shear strength with the modified mixture soil shear strength. The strength tests were conducted on the laboratory scale using the triaxial test device for the Unconsolidated Undrained (UU) test. Soft clay sample was mixed with the chop of plastic sacks fibre with the following level of composition : 0.4 % , 0.6 %, 0.8 %, 1 %, and also the bran ash composition content of 0 %, 2 % and 4 % to the dry weight of soil with the test unit of 36 pieces. Based on laboratory testing, the maximum cohesion value reside on variation of 0.8 % plastic sacks fibre and 2 % bran ash with the value of 0.65 kg/cm2, and the maximum shear angle lays on variation of 1 % of plastic sacks fibre and 0 % of bran ash with the value of 9.95 degree. For the mixture variation of 0.8 % plastic sacks fibre and 2 % of bran ash, it produced a shear strength of 0.67 kg/cm2 and abled to increase the soil shear strength by 87.08 %. As a conclusion, the use of plastic sacks fibre and bran ash was found to be able to improve the soft clay shear strength properties.
CHALLENGES IN DESIGN AND CONSTRUCTION OF DEEP EXCAVATION FOR KVMRT IN KUALA LUMPUR LIMESTONE FORMATION
Authors: Tan Yean-Chin , Chow Chee-Meng , Koo Kuan-Seng , Nazir Ramli 
Published: October 2016

The Klang Valley Mass Rapid Transit (KVMRT) Sungai Buloh - Kajang Line project is the first Mass Rapid Transit (MRT) project in Malaysia. The KVMRT Project when completed will cover a distance of 51km and comprises of 31 passenger stations. This paper covers the challenges in design and construction of deep excavation works for three underground stations, namely Tun Razak Exchange (TRX) station, Cochrane Station and Maluri Station, as well as one portal (South Portal) all located in Kuala Lumpur limestone formation. The Kuala Lumpur Limestone formation exhibits notorious karstic features with irregular bedrock profiles, variable weathering condition, cavities and slime zones. This paper presents the design principles of temporary earth retaining system together with vertical rock excavation to the final depth of the station in karstic limestone formation. The unique experience (design and construction) gained from this project will be a useful reference for similar excavation works, especially in karstic limestone formation
EFFECT OF NOSE BLADE ANGLE ON FACE STABILITY OF JACKED BOX TUNNELLING
Authors: A. Prakoso Widjojo , Sabbah Azzah Balqis 
Published: October 2016

A typical jacked box tunnel usually consists of a precast concrete box tunnel and a steel nose blade installed in the box front. Two of many design factors for this tunnel type are the face stability and the face resistance; an increase in face stability is typically accompanied by an unintended consequence of an increase in face resistance. A series of numerical analyses was performed to explore the interaction between the face stability and the face resistance. Three design parameters were considered, namely amount of unexcavated soil inside box tunnel, nose blade angle and soil depth. Plane strain finite element models were used to simulate the tunnel jacking process; the software used was Plaxis 2D. The face stability represented by safety factor is affected mainly in a decreasing order by the amount of unexcavated soil inside box tunnel and the nose blade angle. However, if a minimum jacking force is required, an optimal combination of the two design parameters should be adopted.
INVESTIGATION ON THE MECHANICS OF PRECAST SEGMENT TUNNEL LINING
Authors: Jusoh Siti Norafida , Mohamad Hisham , Marto Aminaton , Alias Nor Eliza , Hezmi Muhammad Azril , Abdullah Rini Asnida , Mohd. Yunus Nor Zurairahetty 
Published: October 2016

Tunnel lining design is an interactive problem, which is not merely about the strength, but how much the lining could deform to accommodate the ground movement. When tunnel interacts with soil, stress from the ground is distributed onto the structure. In precast segmental tunnel lining, it is critical to investigate the lining reaction when applied with load, as this affects the overall flexural behaviour of tunnel lining. The objective of this paper is to understand the basis of tunnel lining mechanical behaviour response. A series of conducted flexural bending laboratory testing and developed numerical models presented here in order to discuss on the mechanics of segmental tunnel lining. By having two different support mechanisms, variation trend in load-deflection and moment bending curve depicted. Mirror trend of pin-pin support can easily be spotted in the results indicated segment lining affected by the load and support design.
Amalan Syura Dalam Kalangan Guru Besar Dan Hubungannya Terhadap Komitmen Kerja Guru
Authors: Abd Hamid Suhana , Mohamad Ahmad Marzuki 
Published: October 2016

This study is design to investigate the implementation of the shura among headmasters that’s influence teachers’ work commitment, and to examine the shura element asli predictability of teachers’ work commitment. This study uses quantitative methods involving 200 respondents among teachers from 23 grade A schools in Johor Bahru. The overall analysis of questionnaire data obtained Cronbach alpha value of 0.946, which showed the highest level of reliability assessment and fulfilling the needs of this study. The data is analys using Statistical Package for the Social Science (SPSS) 22.0. Overall finding shows the implementation of the practice of shura is in a high level, which should be carried out among the teachers. Referring to the second objectives of this study, the analysis proves that elements of the shura; openness, consensus, trust, and trust able to predict work commitments. Based on this result, it can be understood that the elements of the shura competent to improve future teachers’work commitments. It is recommended, for future studies to the investiage the practice of shura in relation with the job satisfaction and school achievement in education. The findings of this study are expected to generate knowledge and understanding in leadership based on a broad practice of shura.
Aplikasi Penderiaan Jauh atau Remote Sensing dalam Pemodelan Pengaruh Iklim terhadap Taburan Burung Hijrah Di Hutan Paya Laut Matang, Perak
Authors: Abd Rahman Azimah 
Published: October 2016

Climate changes especially temperature and rainfall effect the habitat selection of bird migration in mangrove area to get some food and temporary stopover. The increase and decrease of temperature and rainfall is varies between upstream to downstream. This research was done to prove that temperature and rainfall are uneven in some area even in same boundary that can give impact in habitat selection of migratory birds. This research was concern around Matang Mangrove Forest, Perak that already familiar as focal area for migratory birds. Remote Sensing application was used in this research through use of ERDAS Imagine 8.5 which is based on pixels. This application helps to model the relationship between climate, namely temperature and rainfall with distribution density of migratory birds around the study area. Climate modeling was conducted to predict the distribution of migratory bird populations in the future due to changes in temperature and rainfall over a period of 5 years and 20 years. The results of this study showed a decrease in the population of migratory birds by 6.4% for a period of 5 years and a decrease to 7.5% for the last 20 years. Sungai Sepetang and Sungai Selinsing shown that migratory bird populations decreased continuously after 20 years. However the Sangga Besar, Teluk Kertang, Temerlok, Pulau Pasir Hitam dan Sungai Tinggi area showed an increase in the arrival of migratory birds after 20 years. This information analysis help the related agencies in manage and maintain the area around the Matang Mangrove Forest identified potential habitat for migratory birds in the future. In addition, through this study migratory bird monitoring can be carried out systematically on a wider scope without ignoring areas that strives to be the alternative habitat for migratory birds in the future.
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector
Authors: Schleiss Mark R. , Berka Ursula , Watson Elizabeth , Aistleithner Mario , Kiefmann Bettina , Mangeat Bastien , Swanson Elizabeth C. , Gillis Peter A. , Hernandez-Alvarado Nelmary , Fernández-Alarcón Claudia , Zabeli Jason C. , Pinschewer Daniel D. , Lilja Anders E. , Schwendinger Michael , Guirakhoo Farshad , Monath Thomas P. , Orlinger Klaus K. 
Published: October 2016

ABSTRACT
Subunit vaccines for prevention of congenital cytomegalovirus (CMV) infection based on glycoprotein B (gB) and pp65 are in clinical trials, but it is unclear whether simultaneous vaccination with both antigens enhances protection. We undertook evaluation of a novel bivalent vaccine based on nonreplicating lymphocytic choriomeningitis virus (rLCMV) vectors expressing a cytoplasmic tail-deleted gB [gB(dCt)] and full-length pp65 from human CMV in mice. Immunization with the gB(dCt) vector alone elicited a comparable gB-binding antibody response and a superior neutralizing response to that elicited by adjuvanted subunit gB. Immunization with the pp65 vector alone elicited robust T cell responses. Comparable immunogenicity of the combined gB(dCt) and pp65 vectors with the individual monovalent formulations was demonstrated. To demonstrate proof of principle for a bivalent rLCMV-based HCMV vaccine, the congenital guinea pig cytomegalovirus (GPCMV) infection model was used to compare rLCMV vectors encoding homologs of pp65 (GP83) and gB(dCt), alone and in combination versus Freund's adjuvanted recombinant gB. Both vectors elicited significant immune responses, and no loss of gB immunogenicity was noted with the bivalent formulation. Combined vaccination with rLCMV-vectored GPCMV gB(dCt) and pp65 (GP83) conferred better protection against maternal viremia than subunit or either monovalent rLCMV vaccine. The bivalent vaccine also was significantly more effective in reducing pup mortality than the monovalent vaccines. In summary, bivalent vaccines with rLCMV vectors expressing gB and pp65 elicited potent humoral and cellular responses and conferred protection in the GPCMV model. Further clinical trials of LCMV-vectored HCMV vaccines are warranted.
Combined Testing for Chlamydia, Gonorrhea, and Trichomonas by Use of the BD Max CT/GC/TV Assay with Genitourinary Specimen Types
Authors: Van Der Pol Barbara , Williams James A. , Fuller DeAnna , Taylor Stephanie N. , Hook Edward W. 
Published: October 2016

ABSTRACT

The BD Max CT/GC/TV (MAX) assay is a true multiplex assay for simultaneous detection of chlamydia (CT), gonorrhea (GC), and trichomonas (TV). We evaluated assay performance for women using endocervical and vaginal swabs as well as urine specimens. A total of 1,143 women were tested for CT, GC, and TV and, subsequently, another 847 (1,990 total women) for CT and GC only, with positivity rates for CT, GC, and TV of 7.1%, 2.3%, and 13.5%, respectively. In men, the performance for CT and GC was determined using only urine specimens. TV performance was not assessed in male urine samples. Among men, 181/830 (21.8%) and 108/840 (12.9%) chlamydia and gonorrhea infections, respectively, were identified. Comparator assays included BD ProbeTec
Chlamydia trachomatis
Q
x
(CTQ)/
Neisseria gonorrhoeae
Q
x
(GCQ), Hologic Aptima Combo 2 (AC2) and Aptima TV (ATV), trichomonas microscopy, and culture. MAX CT sensitivity was 99.3% (95% confidence interval [CI], 96.1% to 99.9%), 95.7% (90.8% to 98.0%), 91.5% (85.8% to 95.1%), and 96.1% (92.2% to 98.1%) for vaginal swabs, endocervical swabs, female urine samples, and male urine samples, respectively. MAX GC sensitivity was 95.5% (84.9% to 98.7%), 95.5% (84.9% to 98.7%), 95.7% (85.5% to 99.8%), and 99.1% (94.9% to 99.8%) in the same order. MAX TV sensitivity was 96.1% (91.7% to 98.2%) for vaginal swabs, 93.4% (88.3% to 96.4%) for endocervical swabs, and 92.9% (87.8% to 96.0%) for female urine samples. Specificity for all organisms across all sample types was ≥98.6%. Performance estimates for the MAX assays were consistent with estimates calculated for the comparator assays (all
P
values were >0.1). The availability of a CT/GC/TV multiplexed assay on a benchtop instrument with a broad menu has the potential to facilitate local sexually transmitted infection (STI) testing at smaller laboratories and may encourage expanded screening for these highly prevalent infections.