bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini-Review
Authors: Sugishita Yodo , Suzuki-Takahashi Yuki , Yudoh Kazuo 
Published: October 2024

Abstract:
Although a variety of disease-specific biomarkers have been identified for common
lifestyle- or aging-related diseases, there are currently no indices available to measure general
health or the existence of pre-symptomatic conditions in various types of tissue and organ damage.
A rising body of research suggests that sirtuins may have the potential to be used as an index
to assess overall health status and the existence of pre-symptomatic illness states. Sirtuins (SIRTs)
are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases expressed in a variety of human
somatic cells both in health and disease conditions. The activity and expression of SIRTs affect
important metabolic pathways, such as cell survival, senescence, proliferation, energy production,
stress tolerance, DNA repair, and apoptosis, thereby closely linked to aging and longevity.
Given the broad significance of SIRTs in physiological function maintenance, their activity in somatic
cells may reflect the early cross-sectional status of tissue damage caused by aging or systemic
inflammatory responses that are too early to be detected by disease-specific biomarkers. In
this mini-review, we discuss the utility of SIRTs as a surrogate clinical biomarker for health status
to evaluate and monitor health life expectancy and the presence of pre-symptomatic illness states.
Milestones in the Technology of Modified Starch in Pharmaceutical Formulation
Authors: Agnihotri Jaya Anil 
Published: October 2024

Abstract:
Carbohydrates, the most prevalent class of organic substances in living systems, play a
variety of important roles, such as in the creation of energy, the construction of biological structures,
and the synthesis of paper and food. More advanced uses of modified starch have been introduced
over the past millennium, demonstrating that modified starches are promising excipients in drug
delivery, an area in which their role and range of utility continuously increase. Technological
advancements in the pharmaceutical field have led to the development of new and highly stable
molecules with enhanced properties for novel drug delivery systems. Innovative starches from
various sources present exclusive support in the development of novel dosage forms.
Exploring the Efficacy of Convalescent Plasma Therapy in COVID-19 Patients: A Clinical Trial Study
Authors: Mahi-Birjand Motahareh , Ziaee Masood , Alemzadeh Effat , Barkhordari Amin , Azarkar Zohreh , Ebrahimzadeh Azadeh , Abedi Farshid , Azarkar Ghodsiyeh 
Published: October 2024

Background:
In December 2019, a group of patients in Wuhan, Hubei province, China,
presented with severe illness and pneumonia of unknown origin. Subsequently, a novel coronavirus
was identified as the cause and named "2019 novel coronavirus" (2019-nCoV), later defined as
"SARS-CoV-2" (Severe Acute Respiratory Syndrome Coronavirus-2), leading to the development of
the disease known as COVID-19. This study aimed to evaluate the effectiveness and safety of convalescent
plasma as a potential therapy for patients with COVID-19.

Methods:
Patients diagnosed with COVID-19 based on real-time polymerase chain reaction (PCR)
or CT-Scan symptoms were randomly assigned to either the treatment group (n = 29, received convalescent
plasma) or the control group (n = 29). Clinical manifestations and pulmonary involvement
were monitored three times during the study. At the end of the intervention, patients were evaluated
for clinical symptoms, laboratory test results, and length of hospital stay.

Results:
Among the 58 patients who completed the study, there were no significant differences in
baseline characteristics between the treatment and control groups upon admission to the hospital.
However, the length of hospital stay was significantly shorter (9.54 days) in the convalescent plasma
group compared to the control group (12.88 days).

Conclusion:
The findings from this study indicate that the use of convalescent plasma therapy, in
addition to standard treatment, did not result in reduced mortality or improved clinical outcomes at
day 7 when compared to a placebo or control group.
Current State of Scientific Knowledge on Curcumin Encapsulation and Applications
Authors: Zam Wissam , Zahi Mohamed Reda , EL Hattab Mohamed 
Published: October 2024

Abstract:
The yellow pigment curcumin has long been used in traditional medicine for its anti-inflammatory, antibacterial and antioxidant activities. Over the past half-century, scien-tific investigations have shown that curcumin is endowed with additional health benefits be-cause it can modify key molecular targets associated with a number of pathologies, such as diabetes, cancer, and arthritis, in addition to cardiovascular, multiple sclerosis, Alzheimer's, and Crohn's diseases. However, this molecule has several disadvantages, such as low bioavail-ability and solubility, severe oxidative destruction, light sensitivity, fast systemic clearance and breakdown at alkaline pH levels. To address these drawbacks, several methods of micro-encapsulation employing a variety of shell materials have been investigated. These techniques contributed toward the increase of curcumin's solubility and stability against heat, light, oxy-gen, and an alkaline pH. The various shell materials and methods used to microencapsulate this chemical are the main topics of this review. The use of microencapsulated curcumin in food, medicine, and cosmetics is also discussed in more detail. Recent relevant research from the last few years has been given in this area, along with future difficulties.
Incorporation of Calcimimetics into End-Stage Kidney Disease Bundle
Authors: Karaboyas Angelo , Zhao Junhui , Ma Junjie , Moore Carol , Saleem Najma , Martin Kevin J. , Sprague Stuart M. , Smerdon Caroline , Pecoits-Filho Roberto , Pisoni Ronald L 
Published: October 2024

Key Points

After incorporation into the bundle in 2021, etelcalcetide use decreased substantially, reflecting financial incentives to restrict access.Etelcalcetide discontinuers had a swift and sustained increase in parathyroid hormone and loss of secondary hyperparathyroidism control, despite most switching to cinacalcet.These findings have US policy implications not only for etelcalcetide and parathyroid hormone but also for future development of innovative therapies in dialysis.

Background
Calcimimetics, including intravenous etelcalcetide and oral cinacalcet, are often prescribed to hemodialysis patients to prevent complications of elevated parathyroid hormone (PTH) levels. In January 2021, US dialysis reimbursement policy switched from the transitional drug add-on payment adjustment (TDAPA) to an increased bundled payment, with $10.09 per session added for all hemodialysis patients to cover the expense for calcimimetics, whether or not patients are administered etelcalcetide. We leveraged this natural experiment to investigate the effect of this policy change.

Methods
This analysis included 713 US in-center hemodialysis patients enrolled in the United States Dialysis Outcomes and Practice Patterns Study who discontinued etelcalcetide during the TDAPA transition period (December 2020–April 2021). Within a self-matched longitudinal design, within-patient changes in mean PTH, calcium, and phosphorus were assessed in the 6 months before versus after etelcalcetide discontinuation, using linear regression adjusted for potential confounders.

Results
Etelcalcetide use in the United States Dialysis Outcomes and Practice Patterns Study decreased by 58%, from 12% to 5% from July 2020 to 2021; 73% of etelcalcetide discontinuers switched to cinacalcet within 6 months. Comparing the 6 months before versus after etelcalcetide discontinuation, the mean PTH levels increased by 107 (95% CI; 80 to 133) pg/ml, and the prevalence of PTH >600 pg/ml increased by 15% (95% CI; 11% to 19%), from 28% to 43% overall, and increased from 26% to 49% among Black patients. The mean serum calcium and phosphorus levels increased by 0.42 and 0.16 mg/dl, respectively.

Conclusions
Etelcalcetide use decreased substantially after TDAPA ended in January 2021, with most patients switching to cinacalcet. The subsequent increase in PTH levels was swift and sustained and especially pronounced among Black patients, raising concerns about disparities and potential downstream effects on clinical outcomes. Despite the spirit of the policy change, the flat per-treatment increased payment may have inadvertently created a financial incentive to restrict patient access to a more effective therapy and potentially stifle drug innovation.
The The Impact of Task Management, Social Support and Income on Work-Life Balance among Gig Workers
Authors: Mohd Yusof Noorlailahusna , Ismail Nur Hilmi , Abdul Rashid Abdul Rashidi , Khan Hafizah Hammad Ahmad , Mohd Yusof Muhammad Arif Solehin 
Published: October 2024

The study addresses the growing concern about work-life balance among gig workers in Malaysia, a population facing unique challenges due to the nature of gig employment. This issue is particularly critical as gig workers often struggle with task management, securing social support, and dealing with income volatility, all of which impact their ability to achieve a balanced work-life dynamic. This study aims to analyze the effects of task management, social support, and income stability on the work-life balance of gig workers in Malaysia. A quantitative research methodology was employed, involving a survey of 70 gig workers across various sectors in Kedah. The data was analyzed using correlation analysis to assess the relationships between the independent variables, task management, social support, and income stability, and the dependent variable, work-life balance. The findings reveal that task management, social support, and income stability are all significantly correlated with better work-life balance, with task management being the most influential factor. The implications of this study suggest that improving task management practices, enhancing social support systems, and stabilizing income are crucial strategies for gig platforms and policymakers to consider. These measures can significantly improve the well-being of gig workers and contribute to a more sustainable gig economy. The study also highlights the need for further research to explore these relationships in different cultural contexts and over time, to better understand their long-term effects.
Environmental Impact of Heavy Metals on Health in Soils Polluted with Medical Waste in Baiji City
Authors: Salih Khalid Ahmed 
Published: October 2024

Due to the environmental concerns of improper medical waste management inside and outside hospitals and health institutions, this issue is one of the most important environmental studies topics. Four places in Baiji City in Iraq were selected as study areas: Al-Hajjaj Health Center, Al-Boutama Health Center, Al-Zuwai Health Center, and Baiji General Hospital. This study investigates the environmental health risks of incineration treating hospital waste and health centers. According to the data obtained from practical and laboratory studies, Baiji General Hospital had the highest concentrations of the five toxic heavy metals tested, i.e., lead, cadmium, chromium, zinc, and nickel. These values peaked at 98.36, 59.54, 58.74, 79.52, and 13.32 mg/l for Pb+2, Cd+2, Cr+3, Ni+2, and Zn+2, respectively. Exceeding the measured values of toxic metal elements within internationally permissible limits increases the concentration of these toxic metals, posing greater health risks to the population. This process appears clearly and significantly if medical waste is burned in random locations, producing toxic fumes and gases that can cause diseases dangerous to health when inhaled; therefore, there must be mechanisms and scientific management to control the combustion process in private health incinerators. The survey results showed that the indiscriminate burning of medical waste in surveyed areas leads to diseases and can pose a tangible and immediate threat to human life, such as high blood pressure, eye irritations, suffocation of patients with difficulty and shortness of breath, and asthma, especially the elderly and newborns. Original overshooting of the measured values of toxic metal elements within the internationally permissible limits can increase the concentration of these toxic metals, posing more significant health risks to the population.
Penerapan Penilaian Autentik Pada Model Problem Based Learning (PBL) Terhadap Penalaran Konsep Berbasis Marzano Dan Kecerdasan Naturalis Siswa Kelas VII Pada Konsep Pencemaran Lingkungan Di MTs Yaspika Kuningan
Authors: Fauziah Hardini , Nur Sofyan Hasanuddin 
Published: October 2024

Penelitian ini dilatarbelakangi dari proses pembelajaran yang berpusat pada guru sehingga lemahnya kemampuan siswa dalam bernalar dan kecerdasan naturalis siswa. Tujuan dari penelitian ini untuk mengetahui penerapan penilaian autentik pada model PBL terhadap Penalaran Konsep berbasis Marzano dan Kecerdasan Naturalis. Kemampuan bernalar siswa yang tinggi akan memberikan dampak positif terhadap kemampuan memecahkan masalah di kehidupan sehari-hari sedangkan kecerdasan naturalis siswa akan berdampak terhadap kemampuan merawat alam. Metode penelitian yang digunakan adalah metode Kuasi eksperimen, dengan Nonequivalent control group design. Populasi dalam penelitian ini adalah siswa kelas VII MTs Yaspika Kuningan Tahun Pelajaran 2018/2019, sedangkan yang dijadikan sampel penelitian adalah kelas VII D dan VII F. Kelas VII D dengan jumlah 28 orang menggunakan penilaian autentik pada model PBL , sedangkan kelas VII F dengan jumlah 28 orang menggunakan model konvensional. Penalaram konsep siswa dikumpulkan menggunakan tes uraian yang diolah secara kuantitatif, kecerdasan naturalis dikumpulkan menggunakan LKS dan lembar observasi yang diolah secara kualitatif. Berdasarkan hasil penelitian, maka kesimpulan penelitian ini sebagai berikut: 1) Untuk hasil post-test terdapat perbedaan rata-rata yaitu kelas eksperimen lebih tinggi dari kelas kontrol , H0 ditolak dan H1 diterima yaitu penerapan penilaian autentik pada model pembelajaran PBL dapat meningkatkan penalaran konsep berbasis Marzano dan Kecerdasan naturalis siswa kelas VII pada konsep Pencemaran lingkungan di MTs Yaspika Kuningan . 2) Untuk melihat peningkatan hasil dari nilai dari pre-test ke nilai post-test kelas eksperimen dan kelas kontrol maka dilakukan uji N-gain, hasilnya pada kelas eksperimen adalah 0,83 termasuk kedalam kategori tinggi dan untuk kelas kontrol adalah 0,74 termasuk kedalam kriteria sedang. 3) LKS digunakan untuk melihat kemampuan kecerdasan naturalis siswa dan hasilnya kelas eksperimen yang di beri perlakuan lebih tinggi dari kelas control. 4) Lembar observasi guru yang digunakan untuk mengetahui efektivitas penilaian autentik pada model pembelajaran PBL dengan persentasi sebesar 93,33 %. Hal ini menunjukkan bahwa aktivitas guru termasuk kedalam kategori baik sekali.
EKSPLORASI FAKTOR PENENTU TINGKAT AGRESIVITAS PAJAK DALAM PERSPEKTIF TEORI KEUANGAN
Authors: Samiati Tita , Rahmawati Teti , Nurhayati Neni , Maryami Mimi 
Published: October 2024

The purpose of this study is to analyze the factors affecting tax aggressiveness. The research method used is the descriptive verification method. The population in this study is manufacturing companies in various industrial sectors as many as 51 companies listed on the Indonesia Stock Exchange in 2016-2020. The sample used is the annual financial statements of companies in various industrial sectors as many as 34 companies using purposive sampling techniques. The analysis technique used in this study is panel data analysis technique. Profitability has a positive and significant effect on tax aggressiveness, liquidity has a positive and significant effect on tax aggressiveness, leverage has a negative and significant effect on tax aggressiveness Keywords: Tax Aggressiveness, Leverage Ratio, Liquidity Ratio, Profitability Ratio
PENGARUH CORPORATE GOVERNANCE DAN KINERJA KEUANGAN TERHADAP PENGUNGKAPAN TANGGUNG JAWAB SOSIAL PERUSAHAAN
Authors: Syarifudin Syahrul , Nurhayati Enung , Fauziah Fitri 
Published: October 2024

The purpose of the research is to determine about the effect of corporate governance and financial performance to corporate social responsibility disclosure on company manufacture sector of consumer goods industry. This research use descriptive and verifikatif method with quantitative approach and 192 sample of data. The technique data analysis used in this research is panel data regression analysis. Based on the research results can be seen that foreign ownership, public ownership, managerial ownership, board of commissioners size, profitability, leverage, and liquidity simultaneous have significant effect to corporate social responsibility disclosure. partially, foreign ownership has significant positive effect to corporate social responsibility disclosure. public ownership has significant positive effect to corporate social responsibility disclosure. managerial ownership has significant positive effect to corporate social responsibility disclosure. board of commissioners size has significant positive effect to corporate social responsibility disclosure. profitability has significant positive effect to corporate social responsibility disclosure. leverage has significant positive effect to corporate social responsibility disclosure. and liquidity has significant positive effect to corporate social responsibility disclosure.Keywords : Foreign Ownership, Public Ownership, Managerial Ownership, Board of Commissioners Size, Profitability, Leverage, Liquidity and Corporate Social Responsibility Disclosure.
ПУТИ ПОВЫШЕНИЯ ЭФФЕКТИВНОСТИ ДЕГАЗАЦИИ УГОЛЬНЫХ ШАХТ КУЗБАССА
Authors: Шевченко Л.А. 
Published: October 2024

Приводится обзор результатов внедрения длинных скважин в Кузбассе, пробуриваемых с помощью станков направленного бурения до 1000 м для целей дегазации угольных пластов. Отмечаются положительные стороны данной технологии в сравнении с традиционными схемами дегазации. Предлагается методика расчета производительности скважин по экспериментальным кривым их дебита и дается сравнительная оценка работы скважин в условиях крутого и пологого падения. Обосновывается необходимость разработки собственных методов расчета дебита скважин, адаптированных к конкретным горно-геологическим условиям.
A review of the results of the introduction of long wells in the KuzBass, drilled using directional drilling machines to 1000 m for the degassing of coal seams. The positive aspects of this technology are noted in comparison with traditional degassing schemes. A technique is proposed for calculating well productivity from experimental production flow curves, and a comparative assessment of well performance under steep and gentle fall conditions is given. The necessity of developing their own methods for calculating the flow rate of wells, adapted to specific mining and geological conditions, is substantiated.
РАЗВИТИЕ СИСТЕМЫ УПРАВЛЕНИЯ ОХРАНОЙ ТРУДА И ПРОМЫШЛЕННОЙ БЕЗОПАСНОСТЬЮ С УЧЕТОМ МЕЖДУНАРОДНОГО ОПЫТА ПРИМЕНЕНИЯ ЗАКОНОВ
Authors: Павлов А.Ф. , Гаврилов Д.В. , Соболев В.В. 
Published: October 2024

Статья посвящена анализу зарубежного опыта применения законов в области охраны труда и промышленной безопасности. Одним из направлений совершенствования системы управления в сфере охраны труда и промышленной безопасности является изучение международного опыта организации работы по улучшению условий и повышению безопасности труда.
Article is devoted to analysis of foreign experience of laws application in the field of occupational protection and industrial safety. One of the improving directions the management system in the field of occupational and industrial safety is the research of international experience in organizing work to improve working conditions and improve labor safety.
ЭНЕРГЕТИЧЕСКИЕ И ФРИКЦИОННЫЕ ИСТОЧНИКИ ВОСПЛАМЕНЕНИЯ МЕТАНОВОЗДУШНОЙ СМЕСИ ПРИ РАЗРУШЕНИИ УГЛЕПОРОДНОГО МАССИВА
Authors: Ботвенко Д.В. , Казанцев В.Г. 
Published: October 2024

Приведены энергетические и фрикционные источники воспламенения метановоздушной смеси при ведении горных работ на угольных шахтах, необходимость дальнейшего изучения которых обусловлена обеспечением экологичности и безопасности горного производства.
Energy and friction sources of methane-air mixture ignition during mining operations at coal mines are presented, the need for further study of which is due to ecological compatibility and safety of mining production.
О ПРОГНОЗНОЙ КОНЦЕНТРАЦИИ ОКСИДА УГЛЕРОДА И ВОДОРОДАПРИ НИЗКОТЕМПЕРАТУРНОМ ОКИСЛЕНИИ УГЛЯ
Authors: Шлапаков П.А. , Лебедев К.С. , Грачева Т.М. , Хаймин С.А. 
Published: October 2024

Проведены исследования по определению компонентов газовой фазы, в частности оксида углерода и водорода, в пробах воздуха, полученных в результате низкотемпературного окисления как угля, так и сопутствующих вмещающих пород в некоторых случаях. Установлена предполагаемая зависимость прогнозной концентрации оксида углерода и водорода от марки угля.
Researchers have been carried out to determine the components of the gas phase, in particular carbon monoxide and hydrogen, in air samples obtained as a result of low-temperature oxidation of both coal and concomitant enclosing rocks in some cases. The expected dependence of the predicted concentration of carbon monoxide and hydrogen on the grade of coal has been established.
ОЦЕНКА СОСТОЯНИЯ ПОЖАРНОЙ БЕЗОПАСНОСТИ ФЕДЕРАЛЬНОГО ГОСУДАРСТВЕННОГО КАЗЕННОГО УЧРЕЖДЕНИЯ
Authors: Байдельдинова А.С. , Минакова П.С. , Землянухина М.А. 
Published: October 2024

В статье приведена общая характеристика потенциально опасного медицинского учреждения. Для оценки индивидуального пожарного риска, сформулирован сценарий возникновения пожара на объекте. Рассчитано время эвакуации людей на каждом участке здания, проверена система пожаротушения в соответствии с расчетными данными. В статье даны рекомендации по снижению пожарного риска в медицинских учреждениях подобного типа при проведении мероприятий по улучшению пожарной безопасности.
The article describes a potentially dangerous medical institution. To assess the individual fire risk, scenario of fire occurrence at the facility has been formulated. The time for evacuating people at each section of the building was calculated, the fire extinguishing system was checked in accordance with the calculated data. The article provides recommendations for reducing the fire risk in medical institutions, of a similar type for taking measures to improve fire safety.