bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast Cancer in the UAE
Authors: Al-Awadhi Aydah , Iqbal Faryal , Kourie Hampig R. , Al-Shamsi Humaid O. 
Published: September 2024

AbstractIn 2020, breast cancer (BC) was the most diagnosed cancer worldwide, with 2.26 million new cases and 685,000 deaths. In the UAE, breast cancer was one of the leading causes of cancer deaths in 2021, with an estimated average of 9.64% of cancer deaths per year. The total number of breast cancer cases reported to the UAE National Cancer Registry among the UAE population was 1139, representing 20.3% of all malignant cases in 2021. This chapter will review published articles and research data from the United Arab Emirates (UAE) to learn more about the features and outcomes of breast cancer. It will also draw attention to current unmet needs in order to focus on resource allocation and future clinical and research initiatives.
Pancreatic Cancer in the UAE
Authors: Al-Shamsi Humaid O. , Iqbal Faryal , Nijhawan Neil A. , Kourie Hampig R. , Abdelwahed Nadia , Abu-Gheida Ibrahim H. , Ammori Basil 
Published: September 2024

AbstractIn 2021, 110 cases of pancreatic cancer were diagnosed in the UAE population, with 31 cases among UAE citizens and 79 among non-UAE citizens. There is no published data about the stage of presentations in these cases, yet in our experience, it is in keeping with international figures. Presentation with locoregionally advanced and inoperable (30–35%) or metastatic disease (50–55%) remains the most commonly encountered scenario in patients with pancreatic ductal adenocarcinoma, for whom there is no role for palliative resection. The treatment of pancreatic ducal adenocarcinoma, whether early or metastatic, is advanced and largely follows NCCN guidelines in the UAE. One of the major challenges is decentralized surgical care due to the large number of cancer care providers in the UAE, which may affect the surgical outcome in lower-volume centers. The delivery of palliative care for patients with pancreatic cancer varies across the UAE, with variable accessibility based on the institution.
Head and Neck Malignancies in the UAE
Authors: Chintakuntlawar Ashish V. , Al-Halabi Hani , Chehal Aref 
Published: September 2024

AbstractHead and neck squamous cell carcinomas (HNSCCs) are one of the most common malignancies in the world. In this chapter, we discuss the incidence, pathogenesis, treatment, and future challenges in the management of HNSCC in the United Arab Emirates. Tobacco, alcohol, betel nuts, chewing tobacco, and chronic irritation and inflammation of the mucosal surfaces lead to these cancers. Human papillomavirus-associated oropharyngeal cancers (HPV-OPSCCs) occur at a lower rate compared to the western hemisphere. Due to the unique demographics of the UAE, HNSCC is an important cancer to focus on with regards to improving access to treatment, therapeutic paradigms, and research in both epidemiological and interventional clinical trials. In general, the treatment is aligned with international standards of care, with patients receiving expert surgical intervention, advanced radiotherapy treatments, and novel medical treatments, including immunotherapy. However, registry data, access to transoral robotic surgery, and interventional trials are severely lacking and need further collaboration within the oncologic community.
Suggested Quality Control Measures for Cancer Care in the UAE
Authors: Al-Shamsi Humaid O. 
Published: September 2024

AbstractCancer care in the UAE has evolved dramatically in the last few decades, but unfortunately, despite the progress, there is a lack of quality indicators implemented to ensure the delivery of unified and standard treatment for cancer across the UAE. One of the major challenges is the varying degree of experience and training of oncologists who come from all around the globe to practice in the UAE. With many following the NCCN guidelines, there are many others still practicing solo, which may affect the outcome of cancer patients. In this chapter, we will review recommendations for improving the quality of cancer care in the UAE. We recommend the establishment of an independent Advisory Cancer Care Quality Council to monitor the quality of care in both government and private hospitals across the UAE. We recommend adopting a cancer system quality index and also having a regular audit of cancer centers in the UAE to ensure adherence to the quality measure. These measures should address all aspects of cancer care, like radiation, surgical procedures, palliative care, and many others. A focus on quality control should also address the current cancer screening programs and accessibility.
Factors Influencing Seeking Cancer Care Abroad for UAE Citizens
Authors: Al-Shamsi Humaid O. 
Published: September 2024

AbstractA significant number of Emirati cancer patients travel abroad to seek cancer care. Although full-fledged diagnostic and therapeutic cancer care services are available in the United Arab Emirates, patients still travel overseas to seek opinions and treatment. There is a need to disseminate information concerning the type and availability of services and expertise and address the concerns of patients. Also, there is a need to address factors that encourage patients and their families to seek treatment abroad, which may lessen the familial and societal pressures on the patients; supporting extended sick leave for cancer patients and their companions while being treated locally, just as they are abroad; and a physician’s attitude encouraging patients’ decisions to travel abroad. Treatment abroad should be limited to more complex cancer cases requiring specialized cancer care abroad that is unavailable in the United Arab Emirates, after a consensus review by an accredited comprehensive cancer center. Restoring public and community trust in cancer care in the UAE needs special attention and outreach programs at the national level, as well as engagement and commitment from the regulators and sponsoring agencies for traveling abroad. Focused qualitative and quantitative studies are much needed to address factors leading to Emirati patients seeking cancer care abroad and to put a framework in place to address this phenomenon and increase acceptance of being treated locally.
Akute Polyarthritis nach Karibikaufenthalt
Authors: Mayer Johannes , Köhm Michaela , Wahle Matthias 
Published: September 2024

ZusammenfassungEine 59-jährige Patientin wird wegen einer akut aufgetretenen Polyarthritis nach Karibikreise vorgestellt. Begleitend bestehen konstitutionelle Symptome sowie Myalgien und Arthralgien. In der Bildgebung zeigt sich eine Synovitis der Hand- und Fingergrundgelenke ohne erosive Veränderungen. Immunserologisch stellen sich zudem normwertige Befunde ohne Hinweis auf Autoimmunerkrankung oder Vaskulitis dar. In der erweiterten Diagnostik zeigen sich serologische Hinweise für eine Infektion mit dem Chikungunya-Virus.
Bemessungsempfehlungen zur Invalidität in der privaten Unfallversicherung – fachübergreifender Konsens – Stand 09/2024
Authors: Klemm H. T. , Ludolph E. , Willauschus W. , Wich M. , Weber S. , Fuhrmann R. , Heintel T. 
Published: September 2024

ZusammenfassungGrundlage der Leistung eines privaten Unfallversicherers ist die Invaliditätsleistung, die ärztlich fristgerecht festzustellen ist. Der Versicherer gibt pauschalierte Sätze der Gliedertaxe für Verlust oder Funktionsunfähigkeit vor, und der ärztliche Sachverständige muss dann auf allgemein anerkannte Bemessungsempfehlungen zurückgreifen können, um den vorgegebenen Rahmen auf die konkrete, individuelle Situation des Versicherten anwenden zu können. Es handelt sich in dieser Arbeit um fachübergreifend konsentierte Eckwerte der Invaliditätsbemessung, die Grundlage einer einheitlichen ärztlichen Begutachtung von unfallbedingten Funktionsbeeinträchtigungen in der privaten Unfallversicherung sein sollen.Mit Veröffentlichung dieser Bemessungsempfehlungen der FGIMB werden die Empfehlungen von Schröter und Ludolph aus 2009 [12] zurückgenommen, sodass jetzt die Bemessungsempfehlungen der FGIMB an deren Stelle maßgeblich sind.
Fatigue und sensomotorische Instabilität
Authors: Urban Thomas , Reinhardt Fritjof , Lohse Peter , Spitzer Stefan G. , Rasche Luise , Reichmann Heinz 
Published: September 2024

Zusammenfassung
Hintergrund
Für die Behandlung der Symptome des Post-COVID-19-Syndroms wird derzeit keine kausale Therapie nach evidenzbasierten Kriterien breit empfohlen. Die Evaluation der Veränderungen des Leitsymptoms Fatigue und der sensomotorischen Instabilität durch eine individualisierte beanspruchungsgesteuerte Trainingstherapie sowie durch eine intensivierte kognitive Verhaltenstherapie war das übergeordnete Ziel der Interventionsstudie über einen 3‑jährigen Zeitraum (Q1-2021 bis Q4-2023).

Methodik
Es wurden in den 3 Jahren im Post-COVID-19-Zentrum Lausitz (Senftenberg) 407 geimpfte nukleokapsidpositive Patienten behandelt. Bei 78 (rd. 19 %) von ihnen wurden als Leitsyndrome Fatigue/immunometabolische Depression und sensomotorische Instabilität konstatiert. Die Evaluation der individualisierten beanspruchungsgesteuerten Trainingstherapie erfolgte anhand der konkreten Post-COVID-19-Syndromatik und motorischer Fatigability-Parameter. Die sekundäre psychosomatische Syndromatik wurde mit kognitiven Fatigability-Parametern und mit Instrumenten der kognitiven Verhaltenstherapie bewertet. Die Untersuchung verhaltensbeeinflussender Parameter fand in Q2-2023 bis Q4-2023 mit einem leitfadengestützten qualitativen Interview unter den Therapieteilnehmern statt.

Ergebnisse
Die Post-COVID-19-Leitsymptomen „Fatigue“, „sensomotorische Instabilität“, „neuropsychiatrische Symptome“, „kardionale/autonome Dysfunktion“ und „Schmerzen“ verbesserten sich signifikant in der Gesamtkohorte sowie bei der geschlechtsspezifischen Analyse. Eine Verschlechterung trat bei „sekundären psychosomatischen Symptomen“ auf. Für alle motorischen Fatigability-Parameter konnte für die Gesamtkohorte mit dem Cohens d-Wert ein therapeutischer Effekt nachgewiesen werden. Positive Wirkungen erzielte eine Intensivierung der kognitiven Verhaltenstherapie durch eine zunehmende Entwicklung der Eigenaktivität der Patienten sowie deren Selbstkontrolle unter Einsatz von Persuasion und Gamification.
Reshetikhin–Turaev TQFTs Close Under Generalised Orbifolds
Authors: Carqueville Nils , Mulevičius Vincentas , Runkel Ingo , Schaumann Gregor , Scherl Daniel 
Published: September 2024

AbstractWe specialise the construction of orbifold graph TQFTs introduced in Carqueville et al. (Orbifold graph TQFTs) to Reshetikhin–Turaev defect TQFTs. We explain that the modular fusion category $$\mathcal {C}_\mathcal {A}$$

C
A

constructed in Mulevičius and Runkel (Quant Topol 13(3):459–523, 2023. https://doi.org/10.4171/QT/170) from an orbifold datum $$\mathcal {A}$$
A
in a given modular fusion category $$\mathcal {C}$$
C
is a special case of the Wilson line ribbon categories introduced as part of the general theory of orbifold graph TQFTs. Using this, we prove that the Reshetikhin–Turaev TQFT obtained from $$\mathcal {C}_\mathcal {A}$$

C
A

is equivalent to the orbifold of the TQFT for $$\mathcal {C}$$
C
with respect to the orbifold datum $$\mathcal {A}$$
A
.
Reviewing theory, design, and analysis of tethering experiments to enhance our understanding of predation
Authors: Rhoades O. Kennedy , Patrick Christopher J. , Ogburn Matthew B. 
Published: September 2024

AbstractPredation is a key process that influences the structure and functioning of ecosystems. Tethering experiments, which involve restraining prey or prey analogs in field settings, are used to evaluate predation with minimal manipulation of predators and the environment. However, tethering experiments alter the behavior of mobile prey, an issue that increases in severity with prey mobility and reliance on that mobility to evade predators, resulting in artifacts that complicate the interpretation of experimental findings. Given their widespread and rapidly evolving use, we review and reconsider the applications of tethering experiments in marine ecosystems, their utility in measuring predation, associated artifacts, theoretical, methodological, and statistical considerations and challenges, and how to overcome these. Breaking down the predation process into its successive stages (encounter, attack, capture, and consumption), we consider that tethering experiments effectively measure two major aspects of predation: (1) relative predation rates (requiring all four stages, and resulting in successful predation) and (2) predation risk (requiring only encounter and attack). We suggest that tethering experiments be designed to test hypotheses that target particular stages or all stages of the predation process and its drivers, through manipulating tethering experimental designs, conducting direct observations of tethering experiments, collecting additional community or environmental data, combining tethering with other experimental approaches, and through statistical analyses. This general approach facilitates both our understanding of the limitations and utility of tethering experiments to compare patterns and identify drivers of predation rates and risk in the field, topics of study that remain underrepresented in the literature.
The Type I+ Forehead in Facial Feminization Surgery
Authors: Moghadam Shahrzad , Shariati Kaavian , Huang Kelly X. , Chin Madeline G. , LaGuardia Jonnby S. , Bedar Meiwand , Khetpal Sumun , Cronin Brendan J. , Lee Justine C. 
Published: September 2024

Abstract

Background
Feminizing fronto-orbital reconstruction involves one of four possibilities with the Ousterhout Type III anterior table frontal sinus osteotomy and setback performed in most patients while the Type I reduction recontouring is reserved for patients without frontal sinuses or thick anterior tables. However, patients with frontal sinuses and either a moderately thick anterior table or a shallow frontal sinus in the sagittal plane represent an intermediate morphology. For such morphologies, we introduce the novel Type I+ fronto-orbital reconstruction technique, consisting of frontal bone recontouring supplemented with anterior table reconstruction and split cranial bone graft.

Methods
Transgender and gender non-conforming patients who underwent Type I+ or Type III feminizing fronto-orbital reconstruction (2019–2023) were included for retrospective review and comparison of techniques.

Results
In the 123 patients (mean age 32.2 ± 9.5 years) included, 6.5% underwent Type I+ and 94.5% underwent Type III feminizing fronto-orbital reconstruction. Morphologically, Type I+ patients displayed a shallower frontal sinus compared to Type III patients (median anterior to posterior table depth 4.1[interquartile range, IQR, 1.1-5.0] versus 9.8[IQR 7.5-12.0]mm, p<0.001). At the maximum prominence, Type I+ patients also demonstrated thicker anterior tables compared to Type III patients (median 6.6[IQR 5.0-8.8] versus 2.2[IQR 0.4-4.7]mm, p=0.001). Patients receiving Type I+ procedures underwent an anterior table reduction of 2.7±1.2mm versus 4.2 ± 1.2mm for Type III procedures in the sagittal plane (p=0.002).

Conclusions
The current work introduces a novel solution to an intermediate frontal sinus phenotype for gender-affirming facial feminization surgery.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Aflibercept im klinischen Alltag: die AURIGA-Studie
Authors: Ulbig Michael , Brinkmann Christian Karl , Mirshahi Alireza , Hoerauf Hans , Allmeier Helmut , Machewitz Tobias , Scholz Paula , Keramas Georgios , Khoramnia Ramin ,   Studienärzte der AURIGA-Studie
Published: September 2024

Zusammenfassung
Hintergrund
AURIGA ist die größte prospektive Real-world-Studie zur Behandlung des diabetischen Makulaödems (DMÖ) bzw. des Makulaödems nach retinalem Venenverschluss mit intravitrealem Aflibercept (IVT-AFL). Hier werden die 24-Monatsdaten der deutschen behandlungsnaiven DMÖ-Kohorte präsentiert.

Methoden
Behandlungsnaive DMÖ-Patienten wurden mit IVT-AFL in der klinischen Routine therapiert. Primärer Endpunkt war die mittlere Änderung des Visus (ETDRS-Buchstaben) zu Monat 12 gegenüber dem Ausgangswert. Die Analyse erfolgte deskriptiv.

Ergebnisse
Die Analyse umfasst Daten von 150 DMÖ-Patienten (54,7 % männlich). Zu Monat 6, 12 und 24 wurden im Mittel (95 %-Konfidenzintervall) Visusgewinne von 4,6 (2,6; 6,5), 4,0 (2,1; 6,5) und 5,0 (3,0; 6,9) Buchstaben im Vergleich zum Ausgangswert (Mittel ±SD: 65,0 ± 15,3 Buchstaben) sowie eine Reduktion der Netzhautdicke um 86 (109; 64) µm, 70 (94; 43) µm und 75 (103; 47) µm vom Ausgangswert (Mittel ±SD: 391 ± 132 µm) erreicht. Zu Monat 24 hatten 54 % der Patienten ≥ 5 Buchstaben gewonnen und 22 % ≥ 15 Buchstaben. Die mittlere Injektionszahl betrug 5,0 ± 1,6 bis Monat 6, 7,1 ± 3,2 bis Monat 12 und 9,0 ± 5,3 bis Monat 24. 68 % der DMÖ-Patienten erhielten ≥ 5 Injektionen bis Monat 6, 56 % ≥ 7 Injektionen im ersten Jahr. Das Sicherheitsprofil entsprach dem früherer AFL-Studien.

Diskussion
In der deutschen AURIGA-Kohorte behandlungsnaiver DMÖ-Patienten unter IVT-AFL-Behandlung im klinischen Alltag zeigten sich ein zügiger und klinisch relevanter Visusgewinn sowie eine Reduktion der zentralen Netzhautdicke. Beides wurden ab Monat 6 mit reduzierter Injektionsfrequenz über 24 Monate erhalten. Im Vergleich zu früheren Real-world-Studien deutet sich zwar eine verbesserte Versorgungsqualität von DMÖ-Patienten im klinischen Alltag an, dennoch besteht weiteres Optimierungspotenzial.
Synchronous intracranial arteriovenous malformation and papillary glioneuronal tumour: hypothesis or reality?
Authors: Stuart Michael , Burnett Adam , Robertson Thomas , Harbison Annabelle , Coulthard Liam , Campbell Robert 
Published: September 2024

AbstractBrain arteriovenous malformations (AVM) rarely occur with spatial and/or temporal co-localisation to intracranial neoplasms. Most prior reports describe this association with high-grade gliomas; however, reports of a co-occurrence with low grade gliomas are very rare. It is unclear whether such cases represent a true co-occurrence of separate pathologies or simply an unusually vascular phenotype of the neoplasm. Most such reports pre-date the era of molecularly defined gliomas. We present the first report of the spatial and temporal co-occurrence of an intracranial arteriovenous malformation traversing and within a papillary glioneuronal tumour, molecularly defined by the presence of SLC44A1::PRKCA fusion. This case was successfully managed by resection of both lesions adhering to the principles of AVM surgery. It is possible these exceptionally rare co-occurrences may have common underlying molecular drivers relating to the mitogen activated protein kinase (MAPK) pathway.
Regionaler Vergleich spezialisierter ambulanter und (teil-)stationärer schmerzmedizinischer Versorgung in Deutschland
Authors: Erlenwein Joachim , Buchholz Johanna , Weißmann Christoph , Hennig Beata , Marschall Ursula , Sumpf Eberhardt , Nolte Johannes , Petzke Frank 
Published: September 2024

Zusammenfassung
Hintergrund, Ziel der Arbeit
Chronische Schmerzen erfordern abgestufte Versorgungskonzepte. Ziel dieser Untersuchung ist die regionale Darstellung bzgl. der Erreichbarkeit von speziellen schmerzmedizinischen Versorgungsangeboten aus Patientenperspektive in Deutschland.

Material und Methoden
Für 1000 aus deutschen Postleitzahlen-Ort-Kombinationen randomisiert generierte Modellpatienten wurden mit einem Routenplaner die Fahrzeit mit Auto (IV) und verfügbare Verbindungen im öffentlichen Personenverkehr (ÖPV) zum nächstgelegenen speziellen schmerzmedizinischen ambulanten und (teil-)stationären Versorgungsangebot erhoben.

Ergebnisse
Ambulante Einrichtungen waren je nach Anteil schmerztherapeutischer Versorgung und Vernetzungsstruktur meistens realistisch erreichbar. Universitäre Schmerzambulanzen lagen im IV zu 70 % (80 % ÖPV) in kritischer, zu 49 % (68 % ÖPV) in unrealistischer Erreichbarkeit. Teilstationäre Angebote zur interdisziplinären multimodalen Schmerztherapie (IMST) lagen von 68 % der analysierten Wohnorte im IV (83 % ÖPV) in kritischer und von 49 % (75 % ÖPV) in nicht realistischer Fahrzeitentfernung bei engerer Anbindung bzw. häufigerer Anreise. Stationäre IMST waren häufiger realistisch erreichbar (IV 39 % kritisch, 14 % nicht realistisch, ÖPV 61 % kritisch, 48 % nicht realistisch).

Diskussion
Die Ergebnisse zeigen, dass bundesweit relevante Unterschiede je nach Wohnort in der Erreichbarkeit von Einrichtungen zur speziellen Schmerzbehandlung bestehen. Mit Blick auf die Behandlung eines chronischen Krankheitsbilds mit langfristiger therapeutischer Zielsetzung und mit der Notwendigkeit abgestufter Versorgung offenbaren die Ergebnisse aus Patientenperspektive eine teils kritische Versorgung.
Tutton salt (NH4)2Zn(SO4)2(H2O)6: thermostructural, spectroscopic, Hirshfeld surface, and DFT investigations
Authors: de Oliveira Neto João G. , Viana Jailton R. , Abreu Kamila R. , da Silva Luiz F. L. , Lage Mateus R. , Stoyanov Stanislav R. , de Sousa Francisco F. , Lang Rossano , dos Santos Adenilson O. 
Published: September 2024

Abstract
Context
Ammonium Tutton salts have been widely studied in recent years due to their thermostructural properties, which make them promising compounds for application in thermochemical energy storage devices. In this work, a detailed experimental study of the Tutton salt with the formula (NH4)2Zn(SO4)2(H2O)6 is carried out. Its structural, vibrational, and thermal properties are analyzed and discussed. Powder X-ray diffraction (PXRD) studies confirm that the compound crystallizes in a structure of a Tutton salt, with monoclinic symmetry and P21/a space group. The Hirshfeld surface analysis results indicate that the main contacts stabilizing the material crystal lattice are H···O/O···H, H···H, and O···O. In addition, a typical behavior of an insulating material is confirmed based on the electronic bandgap calculated from the band structure and experimental absorption coefficient. The Raman and infrared spectra calculated using DFT are in a good agreement with the respective experimental spectroscopic results. Thermal analysis in the range from 300 to 773 K reveals one exothermic and several endothermic events that are investigated using PXRD measurements as a function of temperature. With increasing temperature, two new structural phases are identified, one of which is resolved using the Le Bail method. Our findings suggest that the salt (NH4)2Zn(SO4)2(H2O)6 is a promising thermochemical material suitable for the development of heat storage systems, due to its low dehydration temperature (≈ 330 K), high enthalpy of dehydration (122.43 kJ/mol of H2O), and hydration after 24 h.

Methods
Computational studies using Hirshfeld surfaces and void analysis are conducted to identify and quantify the intermolecular contacts occurring in the crystal structure. Furthermore, geometry optimization calculations are performed based on density functional theory (DFT) using the PBE functional and norm-conserving pseudopotentials implemented in the Cambridge Serial Total Energy Package (CASTEP). The primitive unit cell optimization was conducted using the Broyden–Fletcher–Goldfarb–Shanno (BFGS) algorithm. The electronic properties of band structure and density of states, and vibrational modes of the optimized crystal lattice are calculated and analyzed.

Graphical abstract