bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Stability of DNA Nanostructures by Incorporation of Unnatural Base Pairs
Authors: Liu Qing , Liu Guocheng , Wang Ting , Fu Jing , Li Rujiao , Song Linlin , Wang Zhen‐Gang , Ding Baoquan , Chen Fei 
Published: August 2017

AbstractSelf‐assembled DNA nanostructures hold great promise in the fields of nanofabrication, biosensing and nanomedicine. However, the inherent low stability of the DNA double helices, formed by weak interactions, largely hinders the assembly and functions of DNA nanostructures. In this study, we redesigned and constructed a six‐arm DNA junction by incorporation of the unnatural base pairs 5‐Me‐isoC/isoG and A/2‐thioT into the double helices. They not only retained the structural integrity of the DNA nanostructure, but also showed enhanced thermal stability and resistance to T7 Exonuclease digestion. This research may expand the applications of DNA nanostructures in nanofabrication and biomedical fields, and furthermore, the genetic alphabet expansion with unnatural base pairs may enable us to construct more complicated and diversified self‐assembled DNA nanostructures.
Improving functional outcome in bipolar disorder: A pilot study on metacognitive training
Authors: Haffner Paula , Quinlivan Esther , Fiebig Jana , Sondergeld Lene‐Marie , Strasser Elisa Sophie , Adli Mazda , Moritz Steffen , Stamm Thomas Josef 
Published: August 2017

BackgroundEffective group psychological interventions in bipolar disorder are rare. In this study, we present “metacognitive training (MCT) for bipolar disorder”—an adaption of a group intervention that has proven effective in other severe psychiatric disorders. MCT is a structured, interactive approach that addresses cognitive biases, social cognition, and self‐esteem. In this pilot study, we investigated psychosocial functioning as primary outcome measure, as well as the feasibility of MCT and its acceptance among bipolar patients.MethodsThirty‐four outpatients with bipolar disorder were recruited. Inclusion criteria were euthymia and psychosocial functioning with a score >11 assessed by the Functional Assessment Short Test. The subjects received eight weekly MCT sessions. Before and after the intervention, psychosocial functioning, quality of life (QoL), and patient views were assessed.ResultsPatients improved significantly in global psychosocial functioning, with a large effect size from baseline to post‐treatment. Over the intervention period, patient QoL improved significantly in terms of their physical health, however not for other QoL subdomains. Treatment adherence was 80%, and patients' appraisal of the training was positive.LimitationsAs this study lacks a control group, it is not possible to ascertain whether the positive treatment effects are attributable to MCT. Additionally, it is unclear whether gains in psychosocial functioning would have been maintained long term.ConclusionsThis pilot trial conclusively shows that MCT is feasible and provides preliminary evidence for both the acceptance and efficacy of MCT. Further studies with larger samples and control condition will be necessary to build on these findings.
How do women's partners view perinatal mental health services? A qualitative meta‐synthesis
Authors: Lever Taylor Billie , Billings Jo , Morant Nicola , Johnson Sonia 
Published: August 2017

AbstractObjectivesPerinatal mental health difficulties are prevalent among women and can adversely affect their partners too. There is also increasing recognition that a woman's partner can play a vital role in relation to her perinatal mental health and should be supported and involved in decisions about her care. Yet it is unclear how services are experienced by the partners of women with perinatal mental health difficulties. This study aimed to synthesize qualitative evidence of partners' views of perinatal mental health care.MethodsA systematic search of 5 electronic databases identified 20 studies that met the inclusion criteria. The findings of these studies were synthesized using an approach based on meta‐ethnography.ResultsSix themes were identified, namely, the marginalization and neglect of women's partners, an unmet need for information, partners' ambivalence about involvement and support, practical barriers to involvement, views about support for women's partners, and the impact on partners of the care women received.ConclusionsGiven the importance of women's partners in relation to perinatal mental health as well as to women's engagement with support and treatment outcomes, greater consideration should be given to their needs to ensure they feel well informed and involved in perinatal mental health care, rather than marginalized. However, professionals also need to challenge the barriers to involvement and support that women's partners face and consider the ways in which services may reinforce these barriers.
Al2O3 Underlayer Prepared by Atomic Layer Deposition for Efficient Perovskite Solar Cells
Authors: Zhang Jinbao , Hultqvist Adam , Zhang Tian , Jiang Liangcong , Ruan Changqing , Yang Li , Cheng Yibing , Edoff Marika , Johansson Erik M. J. 
Published: August 2017

AbstractPerovskite solar cells, as an emergent technology for solar energy conversion, have attracted much attention in the solar cell community by demonstrating impressive enhancement in power conversion efficiencies. However, the high temperature and manually processed TiO2 underlayer prepared by spray pyrolysis significantly limit the large‐scale application and device reproducibility of perovskite solar cells. In this study, lowtemperature atomic layer deposition (ALD) is used to prepare a compact Al2O3 underlayer for perovskite solar cells. The thickness of the Al2O3 layer can be controlled well by adjusting the deposition cycles during the ALD process. An optimal Al2O3 layer effectively blocks electron recombination at the perovskite/fluorine‐doped tin oxide interface and sufficiently transports electrons through tunneling. Perovskite solar cells fabricated with an Al2O3 layer demonstrated a highest efficiency of 16.2 % for the sample with 50 ALD cycles (ca. 5 nm), which is a significant improvement over underlayer‐free PSCs, which have a maximum efficiency of 11.0 %. Detailed characterization confirms that the thickness of the Al2O3 underlayer significantly influences the charge transfer resistance and electron recombination processes in the devices. Furthermore, this work shows the feasibility of using a high band‐gap semiconductor such as Al2O3 as the underlayer in perovskite solar cells and opens up pathways to use ALD Al2O3 underlayers for flexible solar cells.
3 D Porous Nickel–Cobalt Nitrides Supported on Nickel Foam as Efficient Electrocatalysts for Overall Water Splitting
Authors: Wang Yueqing , Zhang Baohua , Pan Wei , Ma Houyi , Zhang Jintao 
Published: August 2017

AbstractExploring highly efficient and durable bifunctional electrocatalysts from earth‐abundant low‐cost transition metals is central to obtaining clean hydrogen energy through large‐scale electrolytic water splitting. Porous nickel–cobalt nitride nanosheets on macroporous Ni foam (NF) are synthesized through facile electrodeposition followed by a one‐step annealing process in a NH3 atmosphere. The transformation from a metal hydroxide into a metal nitride could efficiently enhance the electrocatalytic performance for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Interestingly, the incorporation of nickel further boosts the catalytic activity of cobalt nitride. When used as bifunctional electrocatalysts, the obtained nickel–cobalt nitride electrocatalyst shows good stability and superior catalytic performance toward both HER and OER with low overpotentials of 0.29 and 0.18 V, respectively, to achieve a current density of 10 mA cm−2. The good electrocatalytic performance was also evidenced by the fabrication of an electrolyzer for overall water splitting, which exhibits a high gas generation rate for hydrogen and oxygen with excellent stability during prolonged alkaline water electrolysis. The present work provides an efficient approach to prepare a 3 D interconnected porous nickel–cobalt nitride network with exposed inner active sites for overall water splitting.
The impact of DSM‐5 on the diagnosis and severity indicator of eating disorders in a treatment‐seeking sample
Authors: Nakai Yoshikatsu , Nin Kazuko , Noma Shun'ichi , Teramukai Satoshi , Fujikawa Kei , Wonderlich Stephen A. 
Published: August 2017

AbstractObjectiveTo examine the impact of the DSM‐5 on the diagnoses and severity indicators of eating disorders, we conducted a comparative study on the classification of eating disorders including subtypes of anorexia nervosa (AN) between the DSM‐IV and DSM‐5 criteria. In addition, we studied the association of the DSM‐5 severity criteria and clinical variables.MethodParticipants were 304 outpatients, aged 16–45 years, with eating disorders, diagnosed using semi‐structured clinical interviews and the eating disorder examination questionnaire (EDE‐Q). The severity of AN, bulimia nervosa (BN), and binge‐eating disorder (BED) was rated from mild to extreme using the DSM‐5 severity criteria.ResultsThe DSM‐5 remarkably reduced the number of diagnoses in the residual category from 37.5% to 9.2% and effectively differentiated the diagnostic groups in eating disorder psychopathology. Unexpectedly, however, the scores of all the EDE‐Q subscales significantly decreased as severity ratings increased in the DSM‐5 AN. Furthermore, while the AN binge‐eating/purging group reported significantly lower severity ratings than the AN restricting group, the former displayed more severe eating disorder psychopathology than the latter. In the BN and BED groups, the level of eating concern increased as severity ratings increased, but the severity groups did not differ on other eating pathology variables.DiscussionThe DSM‐5 effectively reduced the reliance on residual categories and differentiated the diagnostic groups in eating disorder psychopathology. However, our findings show limited support for the DSM‐5 severity specifiers for eating disorders. It is necessary to test additional clinical or functional variables for severity specifiers across eating disorders.
Interleukin‐36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts
Authors: Schmitt Verena , Hahn Madelaine , Kästele Verena , Wagner Olga , Wiendl Maximilian , Derer Anja , Taddeo Adriano , Hahne Stefanie , Radbruch Andreas , Jäck Hans‐Martin , Schuh Wolfgang , Mielenz Dirk , Gay Steffen , Schett Georg , Hueber Axel J , Frey Silke 
Published: August 2017

AbstractThe IL‐1 family member IL‐36α has proinflammatory and pathogenic properties in psoriasis. IL‐36α binds to the IL‐36 receptor leading to nuclear factor kappa B/mitogen activated protein kinase mediated cytokine release. The IL‐36R antagonist prevents recruitment of IL‐1 receptor accessory protein and therefore IL‐36‐dependent cell activation. In inflamed human tissue, we previously could show that resident B cells and plasma cells (PC) express IL‐36α. Further, fibroblast‐like synoviocytes (FLS) produced proinflammatory cytokines upon IL‐36α‐stimulation. We hypothesize an IL‐36‐specific crosstalk between B cells/PCs and FLS permitting a proinflammatory B cell niche. Here, we firstly demonstrated that B cell lines and B cells from healthy donors express IL‐36α and stimulation increased IL‐36α in B cells and primary plasmablasts/PCs. Moreover, FLS respond specifically to IL‐36α by proliferation and production of matrix metalloproteinases via p38/HSP27 signaling. Importantly, IL‐36R‐deficiency abrogated IL‐36α−induced production of inflammatory mediators in FLS and changed the intrinsic FLS‐phenotype. Using an in vitro co‐culture system, we could show that IL‐36R‐deficient FLS had a limited capacity to support PC survival compared to wild‐type FLS. Hence, we demonstrated an IL‐36R‐dependent crosstalk between B cells/PCs and FLS. Our data support the concept of initiation and maintenance of a proinflammatory niche by B cells in the joints.
A site‐consistent method to quantify sufficiency of alternative IMs in relation to PSDA
Authors: Dhulipala Somayajulu L. N. , Rodriguez‐Marek Adrian , Ranganathan Shyam , Flint Madeleine M. 
Published: August 2017

SummaryIn probabilistic seismic demand analysis, evaluation of the sufficiency of an intensity measure (IM) is an important criterion to avoid biased assessment of the demand hazard. However, there exists no metric to quantify the degree of sufficiency as per the criterion of Luco and Cornell (2007). This paper proposes a site‐specific unified measure for degree of sufficiency from all seismological parameters under consideration using a total information gain metric. This unified metric for sufficiency supports not only comparison of the performance of different IMs given a response quantity but also assessment of the performance of a particular IM across different response quantities. The proposed sufficiency metric was evaluated for a 4‐story steel moment frame building, and the influence of ground motion selection on the degree of sufficiency was investigated. It was observed that ground motion selection can have a significant impact on IM sufficiency. Because computing the total information gain requires continuous deaggregation across the IM space, an approximate deaggregation technique that allows for a more practical estimation of marginal deaggregation probabilities is proposed. It is expected that the total information gain metric proposed in this paper will aid in understanding the efficiency‐sufficiency relation, thus enabling the selection of a proper scalar IM for a given site and application in probabilistic seismic demand analysis.
Synthesis of microencapsulated zinc stannate and its application in flame‐retardant poly(vinyl chloride) membrane material
Authors: Zhang Bin , Han Jian 
Published: August 2017

SummaryThe novel core‐shell magnesium dihydroxide (MDH)/zinc stannate (ZS) and melamine‐formaldehyde (MF) resin/MDH/ZS microcapsules were prepared. Their structures were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy, and X‐ray photoelectron spectroscopy analysis techniques, then its flame‐retardant application in poly(vinyl chloride) (PVC) composites. The PVC composites were investigated by the limited oxygen index, smoke density, vertical burning test (UL‐94), cone calorimeter test, scanning electron microscopy, and thermogravimetric analysis. When directly exposed to flame, PVC generated a high‐density char layer, giving PVC a self‐extinguishing property. Furthermore, when the mass ratio of MDH/ZS and MF/MDH/ZS microcapsules were 2/8 and 10/2/8 with 16 wt% loading, the results showed that the limited oxygen index value reached 29% and 33%, and the smoke density value reached 51% and 41%. Thus, the microencapsulated ZS could greatly suppress the generation of the flame and smoke during combustion, showing potential applications as multifunctional advanced composites.Two aspects of this manuscript will make it interesting to general readers of Fire and Materials. The magnesium dihydroxide (MDH)/zinc stannate (ZS) microcapsule was firstly prepared via chemical deposition method, and then melamine‐formaldehyde (MF) resin/MDH/ZS microcapsule was secondly prepared. The smoke density of poly(vinyl chloride) (PVC)/MDH/ZS microcapsule and PVC/MF/MDH/ZS microcapsule composites were less than half of the neat PVC. With the addition of the 16 wt% of MDH/ZS or MF/MDH/ZS microcapsules into PVC, the limited oxygen index value of PVC composites achieved a significantly high limited oxygen index value at 29%, 33%, and the smoke density value of PVC reached 51%, 41%, respectively. They are V‐0 rating in UL‐94 test. The results indicated that MDH/ZS and MF/MDH/ZS microcapsules behaved as an environmental friendly flame retardant and smoke suppressant. Thus, this study demonstrated the great potentials of the intrinsically flame‐retardant MDH/ZS and MF/MDH/ZS microcapsules in the application of high performance matrix resin and composite material.
Identification of an unusual by‐product in the industrial production of 2‐Methyl‐3‐furanthiol
Authors: Ding Rui , Zhang Shishi , He Dawei , Liu Yongguo , Yang Shaoxiang , Sun Baoguo , Tian Hongyu 
Published: August 2017

AbstractA by‐product provided by the producer of 2‐methyl‐3‐furanthiol was characterized by 1D and 2D NMR, GC–MS (EI) and HRMS analyses. It was identified to be 4‐(5‐methyl‐2‐furylthio)‐5‐methyltetrahydrofuran‐2‐thione and its precursor 2‐methyl‐5‐thioacetylfuran was also determined. 2‐Methyl‐5‐thioacetylfuran was formed by the nucleophilic addition of AcSH to the aldehyde group of 4‐oxo‐2‐pentenal during the industrial production of 2‐methyl‐3‐furanthiol. The hydrolysis of 2‐methyl‐5‐thioacetylfuran under basic conditions gave 5‐methyl‐2‐furanthiol, which underwent autothiylation to lead to the formation of 4‐(5‐methyl‐2‐furylthio)‐5‐methyltetrahydrofuran‐2‐thione.
In situ LA‐ICP‐MS trace element analysis of magnetite from the late Neoarchean Gongchangling BIFs, NE China: Constraints on the genesis of high‐grade iron ore
Authors: Sun Xiaohui , Zhu Xiaoqing , Tang Haoshu , Luan Yan 
Published: August 2017

The Precambrian banded iron formations (BIFs) not only relate to the evolution of life, ocean, and atmosphere but also provide important reserves of iron around the world. The Gongchangling iron ore deposit located in the Anshan‐Benxi area of Liaoning Province, China, is oxide facies Algoma‐type BIFs, and the Gongchangling No.2 mining area is famous for the production of high‐grade iron ore in China. Magnetite is the main ore mineral in the Gongchangling iron ore deposit, and the magnetite mainly exhibits three modes of occurrence: BIFs (without actinolite), actinolite‐bearing BIFs, and high‐grade iron ore. Trace elemental compositions of the magnetite with different occurrences of the Gongchangling iron ore deposit were obtained by laser ablation inductively coupled plasma mass spectrometry to constrain the genesis of the high‐grade iron ore. The magnetite from actinolite‐bearing BIFs shows relatively lower contents of Mg, Al, Mn, and Zn compared to the magnetite from BIFs (without actinolite), suggesting that coexisting minerals have played an important role in the trace element concentration in magnetite. The magnetite from high‐grade iron ore has lower contents of Ti and V and higher contents of Al and Mn than counterpart from BIFs (with/without actinolite), indicating that the high‐grade iron ore may be reformed by high temperature metamorphic hydrothermal fluid. The staurolite‐garnet‐biotite schist is the wall‐rock of high‐grade iron ore, and the garnet‐biotite geothermometry is used to evaluate the metamorphic temperature of 593 ± 17 °C. It is proposed that the metamorphic hydrothermal fluid produced during regional metamorphism reformed BIFs to generate high‐grade iron ore.
Reliability and validity of the Spanish version of the IDEAL Schedule for assessing care needs in dementia: Cross‐sectional, multicenter study
Authors: López‐Antón Raúl , Barrada Juan Ramón , Santabárbara Javier , Posadas‐de Miguel Mar , Agüera Luís , Burillo Carmen , Franco Manuel , López‐Álvarez Jorge , Mesa Pilar , Petidier Roberto , Quintanilla Miguel Ángel , Robles‐del Olmo Bernabé , Ventura Tirso , Semrau Maya , Sartorius Norman , Lobo Antonio ,   And the members of the IDEAL Spanish Working Group
Published: August 2017

ObjectiveThe IDEAL Schedule was developed for staging “care needs” in patients with dementia. We here aim to validate the Spanish version, further test its psychometric properties and explore a latent construct for “care needs”.MethodsA multicenter study was done in 8 dementia care facilities across Spain. Patients referred with a reliable ICD‐10 diagnosis of dementia (n = 151) were assessed with the IDEAL Schedule by pairs of raters. Inter‐rater reliability (intra‐class correlation [ICC] coefficients), internal consistency (Cronbach's alpha), and factor analysis were calculated. Convergent validity for individual items was tested against validated Spanish versions of international instruments.ResultsPilot testing with numerical scales supported the feasibility, face, and content validity of the schedule. The psychometric coefficients were good/clinically acceptable: inter‐rater reliability (mean ICC = 0.861; 85% of the ICCs > 0.8), internal consistency (global alpha coefficient = 0.74 in 5 nuclear items), and concurrent validity (global score against the Clinical Dementia Rating schedule, r = 0.63; coefficients for individual items ranging from 0.40 to 0.84, all statistically significant, p < 0.05). Internal consistency was low for the “nonprofessional care” and “social support” dimensions. Factor analysis supported a unidimensional solution, suggesting a latent “care needs” construct.ConclusionThe Spanish version of the IDEAL Schedule confirms the main psychometric properties of the original version and documents for the first time the convergent validity of individual items. Factor analysis identified a latent construct consistent with the concept “care needs” although 2 dimensions need further psychometric research.
Preventive effects of an intergenerational program on age‐related hippocampal atrophy in older adults: The REPRINTS study
Authors: Sakurai Ryota , Ishii Kenji , Sakuma Naoko , Yasunaga Masashi , Suzuki Hiroyuki , Murayama Yoh , Nishi Mariko , Uchida Hayato , Shinkai Shoji , Fujiwara Yoshinori 
Published: August 2017

ObjectivesA growing body of literature indicates that social engagements, such as intergenerational programs, are effective strategies to improve a range of cognitive abilities. The present study examined whether the intergenerational program—REPRINTS—prevents age‐related hippocampal atrophy.MethodsAfter comprehensive baseline assessment, participants were allowed to decide whether to participate in the REPRINTS intervention or in the control group, which required only completion of assessments. REPRINTS participants engaged in group activities that involved reading picture books to children at kindergarten and elementary schools, once every 1 to 2 weeks. A follow‐up assessment was conducted after 6 years. Two MRI scans were performed, one immediately after baseline assessment and the other after 6 years. Volumes of the hippocampus, thalamus, and caudate nucleus were derived from automated segmentation. The analysis included 17 REPRINTS and 42 control‐group participants.ResultsThere was no significant difference in any variable of participants' characteristics at baseline between the REPRINTS and control groups. Hippocampal volume significantly declined in the control group but was maintained in the REPRINTS group. No significant differences between groups in thalamus or caudate nucleus volume were observed. Although cognitive function was unaffected by the program, greater decreases in hippocampal volume were significantly correlated with greater decreases in cognitive performance scores.ConclusionsOur results suggest that the REPRINTS intergenerational program has protective effects on age‐related hippocampal atrophy in older adults. These changes precede improvements in cognitive performance, suggesting the validity of the concept of brain plasticity in later life following social engagement.