bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early photometric and spectroscopic observations of the extraordinarily bright INTEGRAL-detected GRB 221009A
Authors: Sánchez-Ramírez R. , Lang R. G. , Pozanenko A. , Martínez-Huerta H. , Hu Y.-D. , Pandey S. B. , Gupta R. , Ror A. K. , Zhang B.-B. , Caballero-García M. D. , Oates S. R. , Pérez-García I. , Guziy S. , Fernández-García E. J. , Wu S.-Y. , Almeida L. , Aryan A. , Belkin S. , Bom C. R. , Butner M. , Burkhonov O. , Carrasco-García I. , Castellón A. , Castro Tirado M. A. , Chelovekov I. , Egamberdiyev Sh. A. , García-Benito R. , García González S. A. , Grebenev S. , Kilpatrick C. D. , Klunko E. , Makler M. , Minaev P. , Mkrtchyan A. , Moskvitin A. , Navarete F. , Novichonok A. , Pankov N. , Passas-Varo M. , Pérez del Pulgar C. , Reina Terol A. , Smith J. A. , Tinyanont S. , Tucker D. L. , Uklein R. , Volnova A. , Wiesner M. P. , Gritsevich M. , Castro-Tirado A. J. 
Published: September 2024

Context. GRB 221009A, initially detected as an X-ray transient by Swift, was later revealed to have triggered the Fermi satellite about an hour earlier, marking it as a post-peak observation of the event’s emission. This GRB distinguished itself as the brightest ever recorded, presenting an unparalleled opportunity to probe the complexities of GRB physics. The unprecedented brightness, however, challenged observation efforts, as it led to the saturation of several high-energy instruments.
Aims. Our study seeks to investigate the nature of the INTEGRAL-detected GRB 221009A and elucidate the environmental conditions conducive to these exceptionally powerful bursts. Moreover, we aim to understand the fundamental physics illuminated by the detection of teraelectronvolt (TeV) photons emitted by GRB 221009A.
Methods. We conducted detailed analyses of early photometric and spectroscopic observations that span from the Fermi trigger through to the initial days following the prompt emission phase in order to characterize GRB 221009A’s afterglow, and we complemented these analyses with a comparative study.
Results. Our findings from analyzing INTEGRAL data confirm GRB 221009A as the most energetic event observed to date. Early optical observations during the prompt phase negate the presence of bright optical emissions with internal or external shock origins. Spectroscopic analyses enabled us to measure GRB 221009A’s distance and line-of-sight properties. The afterglow’s temporal and spectral analysis suggests prolonged activity of the central engine and a transition in the circumburst medium’s density. Finally, we discuss the implications for fundamental physics of detecting photons as energetic as 18 TeV from GRB 221009A.
Conclusions. Early optical observations have proven invaluable for distinguishing between the potential origins of optical emissions in GRB 221009A, underscoring their utility in GRB physics studies. However, the rarity of such data underscores the need for dedicated telescopes capable of synchronous multiwavelength observations. Additionally, our analysis suggests that the host galaxies of TeV GRBs share commonalities with those of long and short GRBs. Expanding the sample of TeV GRBs could further solidify these findings.
Searching for the mHz variability in the TESS observations of nova-like cataclysmic variables
Authors: Dobrotka A. , Magdolen J. , Janíková D. 
Published: September 2024

Aims. We investigated the fast optical variability of selected nova-like cataclysmic variables observed by the TESS satellite. We searched for break frequencies (fb) in the corresponding power density spectra (PDS). The goal is to study whether these systems in an almost permanent high optical state exhibit preferred fb around 1 mHz.
Methods. We selected non-interrupted light curve portions with durations of 5 and 10 days. We divided these portions into ten equally long light curve subsamples and calculated mean PDS. We searched for fb in the frequency interval from log(f/Hz) = −3.5 to −2.4. We defined as a positive detection when the fb was present in at least 50% of the light curve portions with a predefined minimum number of detections.
Results. We have measured fb in 15 nova-like systems and confirmed that the value of this frequency is clustered around 1 mHz with a maximum of the distribution between log(f/Hz) = −2.95 and −2.84. The confidence that this maximum is not a random feature of a uniform distribution is at least 96%. This is a considerable improvement on the previous value of 69%. We discuss the origin of these fb in the context of the sandwich model in which a central hot X-ray corona surrounds a central optically thick disc. This scenario could be supported by a correlation between the white dwarf mass and fb; the larger the mass, the lower the frequency. We see such a tendency in the measured data; however, the data are too scattered and based on a low number of measurements. Finally, it appears that systems with detected fb have a lower inclination than 60–75°. In higher-inclination binaries, the central disc is not seen and the PDS is dominated by red noise. This also supports the inner disc regions as being the source of the observed fb.
CO2 capture and storage
Authors: Delprat-Jannaud Florence 
Published: September 2024

Carbon dioxide capture and geological storage are not new technologies: CO2 capture and separation has been used in industry for decades, and CO2 injection has been used since the 1970s for enhanced oil recovery. However, a number of obstacles still need to be overcome before they can be deployed on a large scale.
This article reviews existing technologies, both mature and under development, and discusses the issues to be addressed: reducing the cost and energy penalty for CO2 capture, pooling infrastructures for transport, demonstrating the feasibility of mass storage, and the outlook for use.
Implantologische Möglichkeiten – von der Agenesie des Einzelzahnes
bis zur Oligodontie
Authors: Fürhauser Nikolaus , Millesi Werner , Fürhauser Rudolf 
Published: September 2024

ZusammenfassungDie Behandlung von Patienten mit Nichtanlagen von Zähnen erfordert in vielen
Fällen eine interdisziplinäre Zusammenarbeit. Wenn Implantate Teil des
Behandlungskonzeptes sind, dann sollte der Kieferorthopäde über die
erforderlichen Platzverhältnisse Bescheid wissen. Dies gilt insbesondere für die
erforderliche Lückenbreite und die Achsenstellung der benachbarten Zähne. Das
kontinuierliche Kieferwachstum in der Oberkieferfront muss zwar bedacht werden,
stellt aber in praxi bei Implantation nach Abschluss des Hauptwachstumsschubes
keine Kontraindikation dar, sondern kann in den allermeisten Fällen durch einen
Kronentausch ausgeglichen werden.Bei Patienten mit Oligodontie wird die gemeinsame Fallplanung deutlich komplexer
um die Raumaufteilung der vorhandenen Bezahnung interdisziplinär festzulegen.
Die definitive Versorgung sollte dann mit optimalen Zahn- und
Implantatpositionen ein gutes ästhetisches und funktionelles Ergebnis für die
leidgeprüften Patienten ermöglichen. Eine Implantation im frühen jugendlichen
Alter sollte in Erwägung gezogen werden, da diese Patienten in ihrer
psychosozialen Entwicklung unterstützt werden.
White-Spot-Läsionen, Zahnwurzelresorptionen und Medikamente im Rahmen
einer kieferorthopädischen Therapie
Authors: Wiedemeyer Friederike , Kirschneck Christian 
Published: September 2024

ZusammenfassungWhite-Spot-Läsionen (WSL) und Zahnwurzelresorptionen zählen zu den häufigsten
Nebenwirkungen im Rahmen einer kieferorthopädischen Therapie und gefährden oft
ein ansonsten gutes Therapieergebnis. Sind sie erst einmal aufgetreten, sind die
Wahrscheinlichkeit einer Spontanremission gering und die therapeutischen
Möglichkeiten begrenzt. Aus diesem Grund muss der Prävention von WSL und
Zahnwurzelresorptionen im Rahmen einer kieferorthopädischen Behandlung ein
großer Stellenwert eingeräumt werden. Immer mehr Patientinnen und Patienten mit
Bedarf bzw. Wunsch nach einer kieferorthopädischen Therapie, v. a. in der
Erwachsenenbehandlung, stehen unter dem Einfluss von Medikamenten und
entsprechenden, oft chronischen systemischen Erkrankungen, zu deren Therapie
diese regelmäßig eingenommen werden. Deren mögliche Auswirkungen auf die
kieferorthopädische Zahnbewegung und Begleiterscheinungen wie
Zahnwurzelresorptionen werden jedoch meist anamnestisch im klinischen
Praxisalltag nur wenig berücksichtigt, obwohl sie einen wesentlichen Einfluss
auf den Therapieverlauf nehmen können. Im vorliegenden Artikel werden neben
einer epidemiologischen Einordnung die ätiologischen und pathogenetischen
Hintergründe von WSL, deren klinisches Erscheinungsbild und diagnostische
Möglichkeiten sowie präventive und therapeutische Optionen basierend auf der
verfügbaren wissenschaftlichen Evidenz näher beleuchtet, um daraus klinische
Empfehlungen zum Umgang mit diesen Entitäten ableiten zu können. Zudem werden
bekannte Wirkungen von Medikamenten auf die kieferorthopädische Zahnbewegung
dargelegt und klinische Empfehlungen für den Umgang mit diesen Patienten
gegeben.
Zahnärztliche Schlafmedizin
Authors: Korbmacher-Steiner Heike 
Published: September 2024

ZusammenfassungZahnärztliche Schlafmedizin ist das derzeit „medizinischste“ aller
zahnmedizinischen Themen. Gemeinhin als Schnarchen bezeichnet, betrifft die
Schlafapnoe weltweit ca. 1 Milliarde Menschen und entwickelt sich somit
zunehmend zu einer der großen Volkskrankheiten. Hinter der lästigen nächtlichen
Ruhestörung verbirgt sich oftmals das Schlafapnoe-Syndrom, welches bei längerem
Bestehen häufig gravierende Folgen für die allgemeine Gesundheit hervorruft.
Schlaf ist ein lebenswichtiger, physiologischer Ruhezustand des Körpers. Da in
der Mundhöhle der von Schlafstörung betroffenen Patienten häufig klinische
Hinweise in Form von Schlafbruxismus, Zahnfrakturen oder Erosionen vorliegen,
können manchmal auch Zahnärzte in Kombination mit einfachen Fragebögen die
wichtige Verdachtsdiagnose stellen. Aber auch therapeutisch sind
zahnmedizinische Ansätze in der oftmals multidisziplinären Behandlung
abgebildet: Kieferorthopädische skelettale und auch funktionelle
Therapiekonzepte können hinsichtlich des posterioren Rachenraums stabilisierend
und/oder formverändernd wirken und somit präventionsorientiert angreifen. Die
Versorgung erwachsener Patienten mit einer Unterkieferprotrusionsschiene (UPS)
ist in aktuellen Leitlinien festgelegt und dort als Zweitlinientherapie fixiert.
Schlaf bezogene Atmungsstörungen können langfristig erfolgreich häufig nur
interdisziplinär unter Berücksichtigung des Patientenalters, der Ätiologie und
Ausprägung behandelt werden. Die Zahnmedizin ist hierbei zu einem wichtigen
Bestandteil geworden.
Network Activeoncokids – Centralized Physical Activity Counseling for
Children, adolescents, and Young Adults Across German-Speaking Countries
Throughout All Oncological Treatment Phases
Authors: Gauß Gabriele , Kesting Sabine , Boos Joachim , Reinhardt Dirk , Götte Miriam 
Published: September 2024

AbstractReaching age-appropriate physical activity levels is a significant challenge for
many children, adolescents, and young adults (CAYAs) with and following an
oncological disease. Many CAYAs require support in addressing physical
activity-specific questions and need assistance in accessing sports and exercise
offers in their local area. Since many clinics cannot provide such
time-intensive counseling, the nationwide operating network ActiveOncoKids
(NAOK), funded by the German Cancer Aid, offers individualized support to
participate in physical activity (PA). This paper describes the
NAOK-Physical-Activity-Counseling (-PAC) concept and evaluates the initial 200
consultations, focusing on recruitment, objectives, and oncology-specific
parameters. Ultimately, dimensions of barriers and facilitators and intervention
options are discussed.
Development and Validation of the Nursing Information Security Questionnaire
Authors: Zhou Xiaoyun , Jing Xiujuan , Gao Tingting , Liu Hong , Jing Xuebing 
Published: September 2024

Abstract
Background Ensuring the security of nursing information holds substantial importance to nursing outcomes and healthcare system management. The awareness of information security among nurses in China is generally inadequate, and there is a lack of standardized evaluation tools for nurse information security in nursing practice. The nursing sector necessitates the establishment of a robust culture surrounding information security.
Objective The aim of this study was to construct a self-reporting instrument for evaluating nursing information security.
Methods The research team utilized literature analysis and group discussions to draft the item pool. After two rounds of Delphi consultation by 15 experts and pilot testing, the initial questionnaire was formed. Item analysis was carried out on the questionnaire, and the validity and reliability of the instrument were statistically tested by computing the Keiser–Meier–Olkin and Bartlett's tests, an exploratory factor analysis (EFA), a confirmatory factor analysis (CFA), convergent and discriminative validity, descriptive statistics, Cronbach's α, and test–retest reliability.
Results A total of 501 nurses participated in the study, supplemented by the inclusion of five experts who were invited to contribute to the assessment of content validity. Four factors were formed using EFA (n = 250), and the cumulative variance contribution rate was found to be 60.10%. The CFA (n = 251) showed that the model fit was good. The overall Cronbach's α coefficient of the questionnaire was 0.948, and the test–retest reliability was 0.837.
Conclusion Finally, the nursing information security questionnaire (NIS-Q) with 38 items and three dimensions of knowledge, attitude, and practice were formed. A promising assessment instrument for gauging the degree of nursing information security was introduced. Further, a foundational platform was established for implementing specific enhancement strategies aimed at advancing nursing information security.
Biallelic Mismatch Repair Deficiency in Children and Adolescents: A Review of Published and Unpublished Data from India—Need for an Indian Consortium
Authors: Sainulabdin Gazel , Kanvinde Purva , Khurana Ritika , Mudaliar Sangeeta , Bhat K Vasudeva , Shukla Anju , Krishnan V. P. , Krishnan Yamini 
Published: September 2024

Abstract
Introduction Biallelic mismatch repair deficiency or constitutional mismatch repair deficiency (CMMRD) is a rare and aggressive pediatric cancer predisposition syndrome that occurs as a result of homozygous (biallelic) pathogenic variants in mismatch repair genes. The primary malignancies that occur in CMMRD are mainly hematological and brain malignancies. Most published data are from the western populations and the Middle East. Data from India are limited to case reports. We performed an analysis to determine the prevalence of CMMRD in the Indian population.
Materials and Methods All children aged less than 18 years with a diagnosis of CMMRD from various centers in India were included. CMMRD confirmed using genetic, molecular, and clinical criteria by an international consensus was included in the analysis. Literature search and data submitted by individual centers were reviewed.
Results The analysis revealed that 22 children had genetically confirmed CMMRD. The median age of the cohort was 6.5 years, with a male predominance (male:female, 2:1). The classical phenotype of café-au-lait macules was observed in 72.7 % of subjects. The most common pathological variant was found in the PMS2 gene, which accounted for 77.3 % of children. Hematological malignancy (T cell acute lymphoblastic leukemia) was the most common primary malignancy in our study that occurred at a median age of 5 years (interquartile range 4–6 years) followed by brain tumors. The age at initial presentation for CMMRD with mutations in MSH2, MSH6, and PMS2 was 5.4, 4, and 7.5 years, respectively.
Conclusion The diagnosis of CMMRD requires a high index of suspicion for the early diagnosis, management, surveillance, counseling, and testing of family members. The awareness about CMMRD in clinicians is important so that diagnosis is made early, and a second malignancy is detected and treated early. The need for an Indian consortium to determine the actual burden of the disease, genetic characteristics, and course of illness in our country has been emphasized.
Multicenter Clinical Randomized Controlled Trial and Network Pharmacology Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease
Authors: Li Mengge , Dang Zhibo , Qian Peiguo , Yang Zhenhuan , Luo Lei , Li Bo , Xia Xingzhou , Ma Yingjie , Dang Zhongqin , Wang Yuliang 
Published: September 2024

Abstract
Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.
Methods Patients with gastroesophageal reflux disease (GERD) of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group. The control group received oral rabeprazole, whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole. The treatment duration was 8 weeks. Clinical efficacy was observed in both groups after 8 weeks. Network pharmacology was used to analyze the action targets of Zhenzhu Qingyuan Granules and the genes related to GERD, and core targets were inferred. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.
Results The clinical research results showed that the total effective rate in the treatment group was 92.68%, compared with 70.00% in the control group, with a statistically significant difference (p < 0.05). After treatment, both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment (p < 0.05), and the treatment group showed greater improvement than the control group (p < 0.05). Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD, including quercetin, luteolin, and β-sitosterol, with potential action targets such as tumor protein 53 (TP53), protein kinase B (AKT1), and tumor necrosis factor.
Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern, enhance clinical efficacy, and have high safety. This formula may exert therapeutic effects through multiple targets and pathways.
Postchemotherapy Robot-Assisted Retroperitoneal Lymph Node Dissection for Metastatic Testicular Cancer: Initial Experience at a Brazilian Oncology Center
Authors: Campos Tadeu José Fontenele Leite , Lott Felipe Monerrat , Sobel Jan Michael , Oliveira Walter Carlos , Campos Franz Santos 
Published: September 2024

Abstract
Introduction Testicular cancer is the most common neoplasm in men aged 20 to 40 years. Retroperitoneal lymph node dissection plays an essential role in the treatment of such patients. Conventional open surgery has a complication rate of 30 to 36%. Some case series have demonstrated that a robot-assisted technique presented safety, oncological efficacy, and yielded lower complication rates. We retrospectively evaluated peri- and postoperative outcomes of robot-assisted retroperitoneal lymph node dissection after chemotherapy performed in patients at Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Materials and Methods The present study included all patients who underwent postchemotherapy robot-assisted retroperitoneal lymph node dissection for the treatment of metastatic testicular cancer at INCA.
Results From August 2020 to November 2021, 5 robot-assisted retroperitoneal lymph node dissections were performed. The mean size of the resected mass was of 7.28 cm. The mean operative time was of 307.4 minutes, and the mean length of the postoperative hospital stay was of 3.2 days. The complication rate during the first 30 days after surgery was of 0%.
Conclusion Robot-assisted retroperitoneal lymph node dissection for metastatic testicular cancer demonstrated favorable perioperative outcomes, with no readmissions or complications within 30 days. Appropriate selection of patients for this technique is crucial. A larger sample with an extended follow-up is necessary for a definitive conclusion.
Neurological outcomes in neonates treated with therapeutic hypothermia: challenges in a developing country
Authors: Oliveira Rita Farias , Wagner Lucia Helena , Silva Alexandre Sousa da , Rodrigues Maura Calixto Cecherelli de , Lacerda Glenda Corrêa Borges de 
Published: September 2024

Abstract
Background Hypoxic-ischemic encephalopathy (HIE) affects 1.5 newborns per 1 thousand term live births. Therapeutic hypothermia (TH) does not prevent all adverse outcomes. The experience with TH is still limited in Latin America. In Rio de Janeiro, Hospital Universitário Pedro Ernesto treats neonates with HIE since 2017 using the servo-controlled system.
Objective To describe the frequency of epilepsy, altered neurological exam, and neurodevelopmental delay at 12 months of age in patients treated with TH in a reference hospital in Rio de Janeiro and to evaluate the possible risk associations with clinical data and data from complementary exams.
Methods We evaluated medical records from the Neonatal Intensive Care Unit hospitalization and from first evaluation recorded at 12 months of age in the High-Risk Neonate Follow-up Outpatient Sevice.
Results A total of 30 subjects were included in the study. We found epilepsy in 18.2% of the patients, altered neurological exam in 40.9%, and neurodevelopmental delay in 36.4%. We also found a significant relationship between altered magnetic resonance imaging scan and subsequent altered neurological exam. Our findings are in line with those of the international literature, which shows that adverse outcomes are still observed, even when TH is applied. Brazilian data shows our limited access to complementary exams. The rate of loss to follow-up was of 26.6%, probably due to the coronavirus disease 2019 (COVID-19) pandemic and to unfavorable socioeconomic conditions. More time for prospective follow-up and protocol adjustments should contribute to improve our data.
Conclusion High incidences of epilepsy, altered neurological exams, and neurodevelopmental delay were found, despite the use of TH. A more efficient use of resources is needed, as well as measures such as early intervention.
Knowledge of dementia and Alzheimer's disease among healthcare professionals in Peru
Authors: Malaga Marco , Aguirre Rafhael J. , Alva-Diaz Carlos , Custodio Nilton , Lanata Serggio , Montesinos Rosa , Pintado-Caipa Maritza 
Published: September 2024

Abstract
Background Primary care physicians and other healthcare providers report feeling unprepared to treat persons with dementia (PWD), especially in developing countries
Objective We aimed to assess the knowledge of dementia and Alzheimer's disease (AD) among health professionals in both primary and tertiary care in Peru.
Methods We conducted an in-person and virtual survey of healthcare professionals trained in Peru throughout the year 2020. The survey was developed based on a previously published one and reviewed by an expert panel. We compared groups using a Chi-squared test. A Bonferroni corrected p-value of 0.008 was used for statistical significance.
Results Out of 804 surveys, we excluded 56 due to incomplete data. A total of 41.6% of respondents were doctors and 21.8%, nurses. One fifth of participants did not recognize AD as a cause of dementia and over half considered “senile dementia” a valid clinical entity. Scores were higher among those with postgraduate training, multiple patients with dementia, or those who had practiced for over 10 years.
Conclusion There is a low level of knowledge of dementia and AD among health professionals in Peru, which worsens outside of Lima. Pernicious ideas, such as senile dementia, are still significantly present among respondents.