bluuebunny/crossref_metadata_2025_split huggingface dataset:
HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes
Authors: Núñez-Andrade Norman , Iborra Salvador , Trullo Antonio , Moreno-Gonzalo Olga , Calvo Enrique , Catalán Elena , Menasche Gaël , Sancho David , Vázquez Jesús , Yao Tso-Pang , Martín-Cófreces Noa Beatriz , Sánchez-Madrid Francisco 
Published: February 2016

ABSTRACT
HDAC6 is a tubulin deacetylase involved in many cellular functions related to cytoskeleton dynamics, including cell migration and autophagy. In addition, HDAC6 affects antigen-dependent CD4+ T cell activation. In this study, we show that HDAC6 contributes to the cytotoxic function of CD8+ T cells. Immunization studies revealed defective cytotoxic activity in vivo in the absence of HDAC6. Adoptive transfer of wild-type or Hdac6−/− CD8+ T cells to Rag1−/− mice demonstrated specific impairment in CD8+ T cell responses against vaccinia infection. Mechanistically, HDAC6-deficient cytotoxic T lymphocytes (CTLs) showed defective in vitro cytolytic activity related to altered dynamics of lytic granules, inhibited kinesin-1–dynactin-mediated terminal transport of lytic granules to the immune synapse and deficient exocytosis, but not to target cell recognition, T cell receptor (TCR) activation or interferon (IFN)γ production. Our results establish HDAC6 as an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by CTLs.
Environmental Assessment of Soil Along Highways (Novosibirsk)
Authors: Благодатнова  , Blagodatnova Anastasiya 
Published: February 2016

These studies were performed for the first time at the territory of Novosibirsk. Some of the methods have not been
previously used in environmental assessment along the major highways. The approbation of these methods can make
a certain contribution to the theory of bioindication and biological testing (including the data on the environmental
identity of individual species of plants and soil photoautotrophs). Using biological methods has allowed to evaluate
the effects of living systems’ exposure to chronic pollution by vehicles’ emissions, which is impossible to achieve with
traditionally used physicochemical methods that determine the concentration of certain pollutants only at a given time
in a given sample. in the soils of Novosibirsk were found: 63 species of soil algae and cyanobacteria belonging to 42
geniuses, 38 families, 19 orders of 7 classes, 4 groups. Changes of taxonomic and phytocenological organization algocyanobacterial
groups can serve as indicators of the environmental conditions, in particular, they can diagnose the
degree of stress. The article demonstrates the possibility of applying biological methods to estimate the ecological state
of technospheric territories.
The significance of biologically active zones of the skin in the electric exchange of the body with the external environment (on the example, operational damage)
Authors: Новикова  , Novikova E. 
Published: February 2016

This work is devoted to the phenomenon occurring in long-term damage to the biologically active
zones (BAZ) by metal spokes and leading to local and general disorders of the organism corresponding to
the specific damaged BAZ.
On a large clinical material of the application of the apparatuses for external trans-osseous fixation for the
treatment of injuries of bones and joints, the author found the phenomenon of energetic exchange between the
organism and environment, occurring through BAZ and representing a link of the functional system of adaptive
regulation.
This allows to attribute the disorders of the normal energetic exchange due to the skin damage, to important
pathogenetic factors that must be considered in the treatment of trauma patients.
For the first time, the nature of some complications developing in long-term trauma of BAZ, is established
and scientifically proven.
For the first time in academic medicine, the position on the role of BAZ as a functional system of adaptive
regulation of the human body, is proposed and experimentally substantiated.
The state of autonomic regulation and systolic and diastolic function of left ventricle in patients with atherosclerosis of peripheral arteries of the lower limbs during the application of various complex programs of rehabilitation treatment
Authors: Яменсков  , Yamenskov V. 
Published: February 2016

The article reflects the results of applying the complex programs of rehabilitation treatment of
patients with atherosclerosis of lower limb arteries. The authors have proved that the use of complex programs of
rehabilitation treatment in patients with atherosclerosis of lower limb arteries improves autonomic regulation of
the cardiovascular system, this proved by the elimination of hypersympathicotonia to values of eutonia according
cardio-intervalography. This is confirmed by the values of the integral index of autonomic regulation - the tension
index, mainly due to the magnetic effects. It was also defined the improvement of systolic and diastolic
function of left ventricle in patients according to echocardiography, which reflects the improvement in the functioning
of the heart. The research was conducted on 200 patients with atherosclerosis of lower limb arteries.
The efficacy of the programs of balneo- and physiotherapy in patients with atherosclerosis of peripheral arteries of lower extremities
Authors: Яменсков  , Yamenskov V. 
Published: February 2016

The article presents the results of treatment of 200 patients with atherosclerotic changes of
lower limb vessels after realization of the developed complex non-pharmacological programs. The authors studied
the effects of complex rehabilitation treatment program and its individual components on clinical symptoms
in patients with atherosclerosis of lower limb arteries taking into account the pain intensity and the distance of
painless walk.
It is proved that the application of the developed complex program in patients with atherosclerosis of peripheral
arteries of the lower extremities allows to eliminate the clinical symptoms and to increase the distance
walk without pain.
Clinical and hemodynamic predictors of atrial fibrillation recurrence in hypertensive with different pulse wave velocity
Authors: Шаваров  , Shavarov A. , Балабаненко  , Balabanenko I. , Киякбаев  , Kiyakbaev G. 
Published: February 2016

The article presents own experience of treating patients with atrial fibrillation. Asymptomatic
lesion of the target organ is detected in patients with arterial hypertension in the early stages of the disease before
obvious clinical manifestations. The question of studying the mutual influence of arterial hypertension and atrial
fibrillation is important, because this combination significantly increases the risk of cardiovascular events. The
study included 55 patients with hypertension and recurrent atrial fibrillation by the prescription of an average of
11 months with an average frequency of 2 episodes a year. All were performed applanation tonometry,
echocardiography and daily monitoring of blood pressure. The patients were allocated on the 3 groups. Groups
differed significantly by age, the risk of thromboembolic complications on a scale CHA2-DS2-VASc score,
creatinine level. Patients with increased arterial stiffness had the highest heart rate, a shorter return time of the
pulse wave and a higher augmentation index at comparable values of peripheral and central systolic and diastolic
blood pressure. Multivariate regression analysis found that independent predictors of recurrent relapses of atrial
fibrillation in patients with arterial hypertension were age, higher the index on a scale CHA2-DS2-VASc score
and the creatinine levels, the return of the reflected wave. In the group of patients with arterial hypertension and
normal arterial stiffness the positive correlation of the recurrence of atrial fibrillation with age, scale CHA2-DS2-
VASc score, creatinine level, and the maximum daily heart rate. It is necessary to highlight the role of the reflected wave in the modification of arterial stiffness in patients with arterial hypertension and the velocity of
propagation of pulse wave ≥10 m/s, making rational control of heart rate in case reduced elastic properties of
arteries.
Regression analysis forecasting pririrodno focal infections
Authors: Евстегнеева  , Evstegneeva V. , Честнова  , Chestnova Tatyana , Смольянинова  , Smolyaninova O. 
Published: February 2016

Regression analysis - a set of statistical methods for processing of experimental data to a condition
of stochastic dependence study of the value of non-random or random variables to define this relationship.
Statement of the problem of regression analysis is formulated as follows. There is a set of observational results.
Requires a quantitative relationship between the index and factors.
In this paper, we try to establish a quantitative relationship between the incidence of natural - focal infections
and biotic and abiotic factors of the environment. By biotic factors include: the number of infection and the
major carriers and vectors to abiotic factors - weather (average monthly air temperature, the monthly average
rainfall, snow depth in December, January, February, March).
When studying the effect of 22 factors on the incidence of leptospirosis using multiple regression the mathematical
model, which has a low level of trust, and when using the stepwise regression established the influence
of one factor - infection of the common vole of the 22 factors. Level of trust models and model coefficients
are significant. This method allows to determine only the linear relationship between the incidence and natural
factors, as in the case of the nonlinear coupling tightness does not install.
Natural foci of infection is a complex ecological system. Based on the terms of modeling complex systems,
which may include: the possible impact of non-linear elements in the output parameter, synergy and reciprocity
under the joint influence of individual factors, the need to address in some cases categorical factors and
multiple output parameters of a complex system, it is necessary to choose an artificial neural network (ANN),
allowing to realize these conditions in the preparation of a mathematical model of the system.
Spectral Analysis in Solving Problems of Managing Accident Rate in Aviation
Authors: Попов  , Popov Yuriy , Куменко  , Kumenko A. 
Published: February 2016

Based on the analysis of statistical data on the number of aviation accidents per 100 thousand flight hours for the period
of 1960-2012, the article proposes the use of periodogram as a method of spectral analysis to detect cycles and determine
whether there is any indication of flight safety management system at different time intervals. It shows that strategic
influences on safety system (within stable and well-functioning management structure) directly and extensively shape the
trend of relative safety indicator.
Environmental Risks and Factors for Green Areas
Authors: Потапова  , Potapova Elena 
Published: February 2016

Green areas perform many ecosystem services for increasing and supporting the quality of urban environment. Thus, most factors
of people’s welfare depend on and are defined by preservation of greeneries, especially in urban areas with their dense population
and intensive anthropogenic impact that create increased ecological risk. Risk is a qualitative or quantitative estimation of a
hazard linked to undesirable consequences and losses. Risk estimation consists of several stages: risk identification, analysis,
assessment. The paper is based on long-term field studies of green areas in several dozen settlements (predominantly urban).
The field data was recorded in standard geobotanical descriptions and forms as well as in author’s specially developed ecological
assessment charts and defect lists. The main reasons, tendencies and factors of degradation and destruction of green areas were
analyzed. A green area’s inability to fulfill its functions was estimated as the main risk. Nine event groups or secondary risks were
described in the structure of the main risk: destruction and loss of species diversity, its substitution, simplification of vertical and
horizontal structure, diseases, infliction of harm, inhibition and loss of decorative value. Classification and estimation of the risks
are proposed, the main factors that cause a green area’s inability to fulfill its ecological functions are described: construction
works, works for housing and public utilities, car runovers, recreational activities, trampling down, damaging and littering. The
calculation of probabilities for the risk factors was carried out and their patterns were defined.
Book Reviews
Authors: Shen Wenjing 
Published: February 2016

In Book Reviews, we review an extensive and diverse range of books. They cover theory and applications in operations research, statistics, management science, econometrics, mathematics, computers, and information systems. In addition, we include books in other fields that emphasize technical applications. The editor will be pleased to receive an email from those willing to review a book, with an indication of specific areas of interest. If you are aware of a specific book that you would like to review, or that you think should be reviewed, please contact the editor. The following books are reviewed in this issue of Interfaces, 46(1), January–February 2016: Operations Planning: Mixed Integer Optimization Models, Joseph Geunes; Extension of Data Envelopment Analysis with Preference Information: Value Efficiency, Tarja Joro and Pekka J. Korhonen; and Rational Action: The Sciences of Policy in Britain and America, 1940–1960, William Thomas.
Employee Recognition and Performance: A Field Experiment
Authors: Bradler Christiane , Dur Robert , Neckermann Susanne , Non Arjan 
Published: February 2016

This paper reports the results from a controlled field experiment designed to investigate the causal effect of unannounced, public recognition on employee performance. We hired more than 300 employees to work on a three-hour data-entry task. In a random sample of work groups, workers unexpectedly received recognition after two hours of work. We find that recognition increases subsequent performance substantially, and particularly when recognition is exclusively provided to the best performers. Remarkably, workers who did not receive recognition are mainly responsible for this performance increase. Our results are consistent with workers having a preference for conformity and being reciprocal at the same time. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2291 . This paper was accepted by John List, behavioral economics.
Large Market Declines and Securities Litigation: Implications for Disclosing Adverse Earnings News
Authors: Donelson Dain C. , Hopkins Justin J. 
Published: February 2016

This study finds that large marketwide declines in stock prices are associated with higher litigation incidence and settlements even though marketwide events are legally irrelevant. The probability of litigation nearly doubles (from 0.29% to 0.55%) and the amount of settlements also doubles (from $5.0 million to $10.1 million) when earnings disclosures occur during a large market decline, even after controlling for the firm’s market-adjusted return. Furthermore, judges with (without) specialized experience in securities litigation are more (less) likely to dismiss cases triggered by disclosures during large market declines. This pattern is consistent with experienced judges recognizing and dismissing weaker cases. Finally, managers are less likely to disclose adverse news at the end of trading days with large market declines. Although we cannot definitively identify the motive behind this pattern, it is consistent with managers recognizing increased litigation risk during large market declines. This paper was accepted by Mary Barth, accounting.
Cheating and Loss Aversion: Do People Cheat More to Avoid a Loss?
Authors: Grolleau Gilles , Kocher Martin G. , Sutan Angela 
Published: February 2016

Does the extent of cheating depend on a proper reference point? We use a real-effort matrix task that implements a two (gain versus loss frame) times two (monitored performance versus unmonitored performance) between-subjects design with 600 experimental participants to examine whether the extent of cheating is reference dependent. Self-reported performance in the unmonitored condition is significantly higher than actual performance in the monitored condition—a clear indication of cheating. However, the level of cheating is by far higher in the loss frame than in the gain frame under no monitoring. The fear of a loss seems to lead to more dishonest behavior than the lure of a gain. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2313 . This paper was accepted by Uri Gneezy, behavioral economics.
Coronal alignment after total knee arthroplasty
Authors: Lording Timothy , Lustig Sébastien , Neyret Philippe 
Published: February 2016

Recent studies have challenged the long-held notion that neutral mechanical alignment after total knee arthroplasty leads to optimal function and survivorship. The ideal alignment for function and survivorship may actually be different. Kinematic alignment, where components are implanted to re-create the natural flexion/extension axis of the knee, may lead to improved functional results. Residual varus alignment may not adversely impact survivorship provided the tibial component is implanted in neutral alignment.Cite this article: Lording T, Lustig S, Neyret P. Coronal alignment after total knee arthroplasty. EFORT Open Rev 2016;1:12-17. doi: 10.1302/2058-5241.1.000002.
Tendon transfers for irreparable rotator cuff tears: An update
Authors: Axe Jeremie M. 
Published: February 2016

Shoulder dysfunction in the setting of irreparable rotator cuff tears (RCTs) can be treated successfully with different types of tendon transfer:Latissimus dorsi transfer for irreparable posterosuperior RCTs works best for young, active patients with an intact subscapularis, no pseudoparalysis or previous surgery, and a functioning teres minor. A more anatomical transfer for irreparable posterosuperior RCTs is a lower trapezius transfer, and early results are promising. Isolated irreparable tears of the subscapularis can be successfully managed with pectoralis major tendon transfer with a concentric humeral head. However, restricted external rotation (ER) may occur, depending on technique. Pectoralis minor transfer can successfully address combination irreparable tears of the upper border subscapularis and the supraspinatus without significant loss of ER. Rotator cuff arthropathy with ER lag benefits most from a reverse total shoulder arthroplasty and a combination latissimus dorsi and teres major transfer (LDTMT) regardless of patient age.Cite this article: Axe JM. Tendon transfers for irreparable rotator cuff tears: An update. EFORT Open Rev 2016;1:18-24. doi: 10.1302/2058-5241.1.000003
Performing Palestinian identity online: Resistance and reinvention
Authors: Robins Melinda B. 
Published: February 2016

Abstract
This textual analysis of Palestinian blog posts interrogates the expression of Palestinian identity online during and after the failure of the peace talks led by US Secretary of State John Kerry in 2013 and 2014. Results indicate an unyielding reinforcement of resistance narratives alongside a youthful reinvention of collective identity as the decades-long dream for an independent state fades. It also ponders how the online performance of identity allows the speakers to make the personal political as well as public for their audience and for one another.
The social contract and the Iraqi state
Authors: Ismael Jacqueline S. , Ismael Tareq Y. 
Published: February 2016

Abstract
The Anglo-American invasion and occupation of Iraq from 2003 destroyed the Iraqi state in an effort to implant a neoliberal order consonant with wider global design. Despite the humanitarian devastation, however, the destruction of the Iraqi state was insufficient to fracture the national sense of commonweal developed over the modern period. The occupation and implanted new political regime, therefore, focused on the elimination of the widespread and popular Iraqi commitment to beneficial social goods arising out of the exploitation of national resources. Akin to the modern Iraqi state’s effort to develop national citizenry as informed by the ancient archeological record of civilized habitation, a project that met with the defilement of Iraqi culture following 2003, the modern state project had also bound Iraqis to a citizenship based on social programs supported by the natural wealth found under Iraqi soil. With the CPA and its successor governments, the tether between Iraq’s various communities was ruptured through sectarianism and immense political violence. Through a novel exploration of the concept of social contract, this article explores what held Iraqis together as a community and the concerted effort to fracture those ties. The revolutionary government under Prime Minister Abd al-Karim Qasim is highlighted for its role in crafting the progressive and aspirational social compact that successor regimes – regardless of orientation – heeded in order the legitimize themselves. The Ba’thist alterations and modifications are explored in an effort to better understand the landscape prior to the devastation of war, sanctions and occupation that came to confront the Iraqi people with such ruthlessness. Such an analysis presents potential for the formulation of future research to identify successive indigenous solutions to the cleavages found within Iraqi society. Such native solutions would seemingly better inform potential pathways out of the conflagration escalated through external imposition.
Zum Aufgabenbegriff der betriebswirtschaftlichen Organisationslehre
Authors: Luhmann Niklas 
Published: February 2016

Zusammenfassung
Die betriebswirtschaftliche Organisationslehre versteht den Begriff der Aufgabe als einen Grundbegriff, ohne wirklich Klarheit über ihn zu gewinnen. Gemeinsames Moment aller Definitionen ist der Zweckbegriff, strittig dagegen ist die differentia specifica in Form einer Zweck-Mittel-Relation. Alle Definitionsversuche deuten auf einen Zusammenhang mit einem Verständnis von Organisationen als Handlungssysteme hin. Die betriebswirtschaftliche Organisationslehre verwendet den Systembegriff im Sinne eines Ganzes / Teil-Schemas, das sie mit der Zweck / Mittel- Unterscheidung weitgehend kongruent setzt. Aus dem latenten Systembegriff und dem weitgehend ungeklärten Verhältnis von Zweck und Mittel resultieren aber eine Reihe von Erkenntnisblockaden: Systemprobleme werden als reine Ordnungsprobleme behandelt; eine Rationalisierung der Organisation erfolgt nur mit Blick auf spezifische Umwelten; Organisationsfragen und damit das Verhältnis von Struktur und Prozeß werden aus der Behandlung betriebswirtschaftlicher Probleme ausgeklammert; die Unterscheidung von Konditional- und Zweckprogrammen wird nicht berücksichtigt; die Kommunikationsstruktur innerhalb der Organisation wird nur unzureichend erfasst. Deshalb fragt der Beitrag abschließend, ob nicht die soziologische Organisationstheorie bessere Ansatzpunkte für die Behandlung des Problems von Zweck- und Systembegriff bereithält.