bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry
Authors: Sanabria-Salas María Carolina , Hernández-Suárez Gustavo , Umaña-Pérez Adriana , Rawlik Konrad , Tenesa Albert , Serrano-López Martha Lucía , Sánchez de Gómez Myriam , Rojas Martha Patricia , Bravo Luis Eduardo , Albis Rosario , Plata José Luis , Green Heather , Borgovan Theodor , Li Li , Majumdar Sumana , Garai Jone , Lee Edward , Ashktorab Hassan , Brim Hassan , Li Li , Margolin David , Fejerman Laura , Zabaleta Jovanny 
Published: February 2017

AbstractSingle-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotype block of the IL1B (-3737C/-1464G/-511T/-31C) and CRC risk, and this association was exclusively observed in individuals with a higher proportion of African ancestry, such as individuals from the Coastal Colombian region (odds ratio, OR 2.06; 95% CI 1.31–3.25; p < 0.01). Moreover, a significant interaction between this CRC risk haplotype and local African ancestry dosage was identified in locus 2q14 (p = 0.03). We conclude that Colombian individuals with high African ancestry proportions at locus 2q14 harbour more IL1B-CGTC copies and are consequently at an increased risk of CRC. This haplotype has been previously found to increase the IL1B promoter activity and is the most frequent haplotype in African Americans. Despite of limitations in the number of samples and the lack of functional analysis to examine the effect of these haplotypes on CRC cell lines, our results suggest that inflammation and ethnicity play a major role in the modulation of CRC risk.
Unravelling the genetic basis of simplex Retinitis Pigmentosa cases
Authors: Bravo-Gil Nereida , González-del Pozo María , Martín-Sánchez Marta , Méndez-Vidal Cristina , Rodríguez-de la Rúa Enrique , Borrego Salud , Antiñolo Guillermo 
Published: February 2017

AbstractRetinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and genetic heterogeneity, RP can be inherited as an autosomal dominant (ad), autosomal recessive (ar) and X-linked (xl) disorder. Although the relative prevalence of each form varies somewhat between populations, a major proportion (41% in Spain) of patients represent simplex cases (sRP) in which the mode of inheritance is unknown. Molecular genetic diagnostic is crucial, but also challenging, for sRP patients because any of the 81 RP genes identified to date may be causative. Herein, we report the use of a customized targeted gene panel consisting of 68 IRD genes for the molecular characterization of 106 sRP cases. The diagnostic rate was 62.26% (66 of 106) with a proportion of clinical refinements of 30.3%, demonstrating the high efficiency of this genomic approach even for clinically ambiguous cases. The high number of patients diagnosed here has allowed us to study in detail the genetic basis of the sRP. The solved sRP cohort is composed of 62.1% of arRP cases, 24.2% of adRP and 13.6% of xlRP, which implies consequences for counselling of patients and families.
Effect of Different Titanium Surfaces on Maturation of Murine Bone Marrow-Derived Dendritic Cells
Authors: Zheng Xiaofei , Zhou Fengjuan , Gu Yifei , Duan Xiaobo , Mo Anchun 
Published: February 2017

AbstractDendritic cells (DCs) play a pivotal role in the host response to implanted biomaterials. Osseointegration of titanium (Ti) implant is an immunological and inflammatory-driven process. However, the role of DCs in this complex process is largely unknown. This study aimed to investigate the effect of different Ti surfaces on DC maturation, and evaluate its subsequent potential on osteogenic differentiation of preosteoblasts. Murine bone marrow-derived DCs were seeded on Ti disks with different surface treatments, including pretreatment (PT), sandblasted/acid-etched (SLA) and modified SLA (modSLA) surface. Compared with DCs cultured on PT and SLA surfaces, the cells seeded on modSLA surface demonstrated a more round morphology with lower expression of CD86 and MHC-II, the DC maturation markers. Those cells also secreted high levels of anti-inflammatory cytokine IL-10 and TGF-β. Notably, addition of conditioned medium (CM) from modSLA-induced DCs significantly increased the mRNA expression of Runx2 and ALP as well as ALP activity by murine preosteoblast MC3T3-E1 cells. Our data demonstrated that Ti disks with different surfaces lead to differential DCs responses. PT and SLA surfaces induce DCs mature, while DCs seeded on modSLA-Ti surface maintain an immature phenotype and exhibit a potential of promoting osteogenic differentiation of MC3T3-E1 cells.
Growth of juvenile Norwegian spring-spawning herring in relation to latitudinal and interannual differences in temperature and fish density in their coastal and fjord nursery areas
Authors: Husebø Åse , Slotte Aril , Stenevik Erling Kåre 
Published: February 2017

Abstract
Husebø, Å., Slotte, A., and Stenevik, E. K. 2007. Growth of juvenile Norwegian spring-spawning herring in relation to latitudinal and interannual differences in temperature and fish density in their coastal and fjord nursery areas. – ICES Journal of Marine Science, 64: 1161–1172. Norwegian spring-spawning herring (Clupea harengus) spawn in February and March along the Norwegian coast from 58°N to 69°N. The larvae are transported north with the coastal current, and in autumn, the main part of the 0-group is found in the Barents Sea, and a smaller and variable fraction ends up in coastal and fjord nursery areas that experience a wide range of environmental conditions and fish densities. Based on data from herring 0–2 years old collected from 1970 to 2004, there is a positive relationship between temperature and the growth of this coastal component, in terms of length, weight, condition factor, and annual otolith increment width, and a negative relationship between acoustic abundance and the same growth indices. In general, juvenile growth decreased northwards along the coast concurrently with decreasing summer and autumn temperatures and increasing acoustic abundance. It seems, therefore, that there may be interference in the relationship between juvenile herring growth and temperature, attributable to variable recruitment, currents, larval drift, and advection into the fjords, causing latitudinal and interannual differences in fish density, and hence variable competition for food.
Migratory abdominal pain
Authors: Kieffer Will 
Published: February 2017

Abstract
A 63 year old woman, presenting as an emergency provides an useful example of the difficulties in diagnosing acute appendicitis when faced with an atypical history. This patient underwent plain radiography, computed tomography, repeat biochemical investigations and finally an exploratory laparotomy before the diagnosis of acute appendicitis was made. The case was confounded by a highly mobile caecal pole which brought the inflamed appendix to lie over the pancreas highlighting the need for vigilance in diagnosing acute appendicitis.
Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika
Authors: Cao Rui-Yuan , Xu Yong-fen , Zhang Tian-Hong , Yang Jing-Jing , Yuan Ye , Hao Pei , Shi Yi , Zhong Jin , Zhong Wu 
Published: February 2017

Abstract
Zika virus (ZIKV) infection can be the cause of congenital malformations, including microcephaly in infants and can cause other disorders such as Guillain-Barré syndrome, meningoencephalitis, and myelitis, which can also occur in some infected adults. However, at this time, there is no drug approved to treat ZIKV infection. Drug repurposing is the promptest way to obtain an effective drug during a global public health emergency such as the spread of Zika virus. In this study, we report a US Food and Drug Admistration-approved drug that is safe for pediatric use. Nitazoxanide and its bioactive metabolite, tizoxanide, have anti-ZIKV potential in vitro, and we identified that they exerts antiviral effect possibly by targeting the viral postattachment step.
SMRFIT: A STATISTICAL ANALYSIS SYSTEM (SAS) PROGRAM FOR STANDARDIZED MORTALITY RATIO ANALYSES AND POISSON REGRESSION MODEL FITS IN COMMUNITY DISEASE CLUSTER INVESTIGATIONS
Authors: HANRAHAN LAWRENCE P. , MIRKIN IRENE , OLSON JOSEPH , ANDERSON HENRY A. , FIORE BETH J. 
Published: February 2017

Abstract
Increasingly, health departments are being pressed by the public to respond to disease risk with cluster investigations in communities and neighborhoods. This is a direct result of growing concern about the role that the environment may play in disease risk. While extensive analyses directly inputing exposures or numbers at risk are often necessary to thoroughly investigate clusters, it is quite useful to perform an exploratory analysis with existing morbidity and mortality data as a first level of response. To meet this need for timely evaluation, the authors describe a user-friendly Statistical Analysis System (SAS) program called SMRFIT to automate community disease cluster evaluations. The program creates frequency tables for number at risk and number of disease outcomes for the community, balance of parent county, and balance of state. SMRFIT then constructs standardized mortality ratios, with the community compared with balance of county and balance of state referents. Poisson regression is offered as an option for the modeling of community disease rates.
STATE HEALTH DEPARTMENT RESPONSE TO DISEASE CLUSTER REPORTS: A PROTOCOL FOR INVESTIGATION
Authors: FIORE BETH J. , HANRAHAN LAWRENCE P. , ANDERSON HENRY A. 
Published: February 2017

Abstract
State health departments are increasingly faced with the task of responding to reports of apparent cancer and other disease clusters. Since 1979, 141 requests for investigation have been received by the Wisconsin Division of Health, with over 60% of these requests occurring since 1985. Mounting public concern and limited resources have resulted in the development of a “disease cluster investigation and analysis protocol.” Protocol steps include: 1) circumscribing the cluster; 2) ascertaining cases; 3) assessing risk of the exposed versus a referent population; 4) statistically analyzing disease rates; 5) examining potential exposure; 6) assessing biologic plausibility; 7) determining cluster significance and need for further investigation; and 8) reporting results. To demonstrate the protocol, the authors present a case example of an investigation of an apparent cancer cluster. Since 1979, 62 reports were resolved with initial contact with informant education (step 1), 61 reports required descriptive analysis (steps 1-8) with no site visit, and 18 reports required site visits. None of the reports required further in-depth epldemiologic investigation. This protocol provides a systematic approach to investigation and analysis, prioritizes the need for more in-depth study, and, when necessary, assuages community concerns when a disease cluster is reported.
QUALITATIVE AND QUANTITATIVE ASSESSMENT OF GEOGRAPHIC CLUSTERING OF POPULATION SAMPLES SELECTED USING DIFFERENT METHODS OF RANDOM DIGIT DIALING
Authors: DAVIS SCOTT , ROSS ANDREW , VOIGT LYNDA F. , HEUSER LINDA 
Published: February 2017

Abstract
Random digit dialing is a method commonly used to select random population samples in epidemiologic research. Although random digit dialing is generally presumed to provide representative samples, coverage and nonresponse errors may affect the degree to which the sample is representative. The present investigation was undertaken to determine whether the geographic distributions of samples selected using variations of the basic random digit dialing technique accurately reflect the underlying population distribution, and if not, whether such samples tend to be either more or less dispersed than the populations from which they were selected. Data regarding control groups from three case-control studies conducted from 1983–1986 were utilized. The residence addresses of 998 controls were located and assigned an X-Y coordinate and census tract designation within a three-county geographic area in northwest Washington State. Initially, the spatial distributions of controls were examined graphically in relation to the age-sex structure of the underlying population. No differences in geographic pattern were apparent A more formal statistical evaluation was conducted based on centrographic techniques utilizing two measures to describe the spatial distribution of a set of points. Results indicate that the samples chosen were neither more nor less dispersed than the underlying populations. However, the geographic centers of samples selected using primary numbers tended to be shifted from the centers of their respective populations. Several possible explanations for such shifts are considered, and extensions of the analytical approach are suggested in relation to the further evaluation of population sampling and the investigation of space-time aggregations of disease.
The Development and Significance of the Root Nodules of Casuarina
Authors: BOND G. 
Published: February 2017

Abstract
Young plants of Casuarina cunninghamiana and of C. equisetifolia growing in water culture developed macroscopic nodules in 26 to 35 days from inoculation, the nodulation being most successful at pH near to neutrality and falling off much more rapidly at lower pH than in other non-legume nodule-forming genera, confirming the distinctiveness of the Casuarina organism. The roots springing from the nodule lobes are shown to be characterized by upward growth and in this to resemble remarkably closely the corresponding roots of Myrica. Nodulated plants of Casuarina are able to grow vigorously in culture solution free of combined nitrogen, showing that fixation of atmospheric nitrogen occurs, amounting in C. cunninghamiana to 50 mg. per plant during 6 months of active growth. The evidence indicates that the fixation occurs in the nodules, and that these have exactly the same functional significance as those of legumes.
Cancer Cell Line Profiler (CCLP): a webserver for the prediction of compound activity across the NCI60 panel
Authors: Cortés-Ciriano Isidro , Murrell Daniel S. , Chetrit Bernard , Bender Andreas , Malliavin Thérèse , Ballester Pedro J. 
Published: February 2017

AbstractSummaryCCLP (CancerCellLineProfiler) is a webserver for the prediction of compound activity across the NCI60 panel. CCLP uses a multi-task Random Forest model trained on 941,831 data-points that integrates structural information from 17,142 compounds and multi-omics data sets from 59 cancer cell lines. In addition, CCLP also implements conformal prediction to provide individual prediction errors at several confidence levels. CCLP computes compound descriptors for a set of input molecules and predicts their activity across the NCI60 panel. The output of running CCLP consists of one barplotperinput compound displaying the predicted activities and errors across the NCI60 panel, as well as a text file reporting the predicted activities and errors in predictionAvailabilityCCLP is freely available on the web atcclp.marseille.inserm.fr
Brand religiosity
Authors: Sarkar Juhi Gahlot , Sarkar Abhigyan 
Published: February 2017

Purpose
The purpose of this paper is to define the brand religiosity phenomenon and develop a theoretical process model showing the interrelationships between brand religiosity and other related concepts leading to the formation of a distinct brand sub-culture or community.

Design/methodology/approach
A large volume of prior literature on consumer–brand relationships has been reviewed to develop the conceptual framework.

Findings
The framework developed shows several actionable antecedents and desirable marketing outcomes of brand religiosity. The framework also depicts that brand religiosity leads to the creation of social anti-structure by forming a distinct brand community that frees individuals from the regular social structure and motivates them to adopt a distinct brand sub-culture formed. Theoretical contributions and business policy-related implications of brand religiosity are discussed.

Originality/value
Value of the study lies in conceptualizing brand religiosity and developing an integrative process model centering the concept.
Effect of visceral pleural invasion on the prognosis of patients with lymph node negative non‐small cell lung cancer
Authors: Tian Dan , Pei Yuquan , Zheng Qingfeng , Zhang Jianzhi , Li Shaolei , Wang Xing , Lin Dongmei , Yang Yue 
Published: February 2017

BackgroundVisceral pleural invasion (VPI) is an adverse prognostic factor in non‐small cell lung cancer (NSCLC); however, its effect in relation to tumor size remains under debate. To better understand the prognostic impact and potential consequences for staging, we examined correlations between VPI and clinicopathologic characteristics in patients with NSCLC, particularly those with lymph node negative NSCLC.MethodsWe retrospectively analyzed 813 cases of radically resected NSCLC treated in our institution between December 2005 and December 2011. Patients were divided into two groups according to VPI status to compare their clinicopathologic characteristics. Survival analysis was performed in 521 cases with pN0 NSCLC.Results
VPI was diagnosed in 379 (46.6%) cases. It was more common in women, patients with non‐squamous cell carcinoma, elevated preoperative serum carcinoembryonic antigen levels, moderately or poorly differentiated tumors, and larger‐sized tumors. The incidence of mediastinal lymph node metastasis, particularly multi‐station metastasis, was higher in patients with VPI. Patients with pN0 NSCLC, 2–3 cm tumors, and VPI had a significantly poorer prognosis (VPI vs. non‐VPI: five‐year overall survival 78.3% vs. 84.5%, P = 0.039; five‐year disease‐free survival 69.2% vs. 80.0%, P = 0.046, respectively); however, no significant effect was observed for tumors ≤2, 3–5, and 5–7 cm. P‐N0 patients with VPI had a significantly higher incidence of postoperative local recurrence and distant metastasis than those without VPI (P = 0.01), especially ipsilateral pleural recurrence.Conclusion
VPI was an adverse prognostic factor in radically resected pN0 NSCLC, especially for tumors 2–3 cm in size.
Analysing model fit of psychometric process models: An overview, a new test and an application to the diffusion model
Authors: Ranger Jochen , Kuhn Jörg‐Tobias , Szardenings Carsten 
Published: February 2017

Cognitive psychometric models embed cognitive process models into a latent trait framework in order to allow for individual differences. Due to their close relationship to the response process the models allow for profound conclusions about the test takers. However, before such a model can be used its fit has to be checked carefully. In this manuscript we give an overview over existing tests of model fit and show their relation to the generalized moment test of Newey (Econometrica, 53, 1985, 1047) and Tauchen (J. Econometrics, 30, 1985, 415). We also present a new test, the Hausman test of misspecification (Hausman, Econometrica, 46, 1978, 1251). The Hausman test consists of a comparison of two estimates of the same item parameters which should be similar if the model holds. The performance of the Hausman test is evaluated in a simulation study. In this study we illustrate its application to two popular models in cognitive psychometrics, the Q‐diffusion model and the D‐diffusion model (van der Maas, Molenaar, Maris, Kievit, & Boorsboom, Psychol Rev., 118, 2011, 339; Molenaar, Tuerlinckx, & van der Maas, J. Stat. Softw., 66, 2015, 1). We also compare the performance of the test to four alternative tests of model fit, namely the M2 test (Molenaar et al., J. Stat. Softw., 66, 2015, 1), the moment test (Ranger et al., Br. J. Math. Stat. Psychol., 2016) and the test for binned time (Ranger & Kuhn, Psychol. Test. Asess. Model., 56, 2014b, 370). The simulation study indicates that the Hausman test is superior to the latter tests. The test closely adheres to the nominal Type I error rate and has higher power in most simulation conditions.
Unraveling the roles of orienting and inhibition in the Concealed Information Test
Authors: klein Selle Nathalie , Verschuere Bruno , Kindt Merel , Meijer Ewout , Ben‐Shakhar Gershon 
Published: February 2017

AbstractThe Concealed Information Test (CIT) is a well‐validated tool for physiological and behavioral detection of concealed knowledge. Two distinct theoretical frameworks have been proposed to explain the differential responses to the concealed critical items: orienting response theory versus arousal inhibition theory. klein Selle, Verschuere, Kindt, Meijer, and Ben‐Shakhar (2016), however, argued for a response fractionation model and showed that, while the skin conductance reflects pure orienting, both the respiratory and heart rate measures reflect arousal inhibition. The present study intends to (1) provide a constructive replication of klein Selle et al. (2016) using the autobiographical CIT, and (2) extend their work by testing an additional prediction derived from orienting theory, using an item‐salience manipulation. One hundred and nine participants were tested on four high salient and four low salient identity items. Half of the participants were motivated to hide their identity (orienting + arousal inhibition), while the other half were motivated to reveal their identity (orienting only). Confirming earlier findings, the results revealed a fractionation between the different measures: while the skin conductance response (SCR) increased to a similar extent in the two motivational conditions, the respiration line length (RLL) shortened and the heart rate (HR) decelerated solely in the conceal condition. Moreover, while the SCR was larger for high than for low salient critical items, the RLL and HR responses were similar for these two item types. These data led us to conclude that, in the CIT, the skin conductance measure reflects orienting and the respiratory and heart rate measures reflect arousal inhibition.
Investigating laparoscopic psychomotor skills in veterinarians and veterinary technicians
Authors: Kilkenny Jessica , Santarossa Amanda , Mrotz Victoria , Walker Meagan , Monaghan Dominique , Singh Ameet 
Published: February 2017

AbstractObjectivesTo determine the influence of age, year of graduation, and video game experience on baseline laparoscopic psychomotor skills.Study designCross‐sectional.Sample Population: Licensed veterinarians (n = 38) and registered veterinary technicians (VTs) (n = 49).MethodsA laparoscopic box trainer was set up at the 2016 Ontario Veterinary Medical Association (OVMA) and the 2016 Ontario Association of Veterinary Technicians (OAVT) conferences held in Toronto, Ontario, Canada. Participants volunteered to perform a single repetition of a peg transfer (PT) exercise. Participants were given a short demonstration of the PT task prior to testing. A Spearman's rank correlation (rs) was used to identify associations between baseline psychomotor skills and self‐reported surgical and non‐surgical experiences collected via survey. Mann‐Whitney U tests were used to compare PT scores in veterinarians and VTs. A P‐value of < .05 was considered significant.ResultsThe mean age of participants was 36 years (range 21‐67) and the majority were female (83%). In veterinarians, PT scores were highest in the most recent graduates (P = .01, rs = 0.42), and PT scores increased with self‐reported VG experience (P = .02, rs = 0.38). PT scores correlated inversely with age (P = .02, rs = −0.37). No associations were observed in VTs (P > .05). Veterinary technicians that frequently used chopsticks scored higher than those without chopstick experience (P = .04).ConclusionsAge and year of graduation correlated inversely, while self‐reported VG experience correlated positively with laparoscopic psychomotor skills of veterinarians, when assessed on a simulator. The use of chopsticks may contribute to the acquisition of psychomotor skills in VTs.