bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study
Authors: Kendzerska Tetyana , Gershon Andrea S. , Hawker Gillian A. , Tomlinson George A. , Leung Richard S. 
Published: June 2017

We evaluated whether obstructive sleep apnoea (OSA) was related to the incidence of hospitalisation for depression, a robust end-point that is unlikely to result from misdiagnosis.All adults referred with suspected OSA who underwent a diagnostic sleep study at a large urban academic hospital between 1994 and 2010 and were linked to provincial health administrative data between 1991 and 2015 were included. Cox regression analysis was used to investigate the association between OSA symptoms and severity and incident hospitalised depression, the primary outcome.Over a median follow-up of 9.7 years, 136 (1.3%) out of 10 149 participants were hospitalised for depression. A significant crude effect of OSA symptoms (waking unrefreshed and impact on memory and concentration) on hospitalised depression became nonsignificant after controlling for confounders. Apnoea–hypopnoea index was not significantly associated with the outcome: adjusted hazard ratio (33 versus6 events·h−1) 1.13 (95% CI 0.91–1.40). Factors associated with hospitalised depression were female sex, younger age, use of hypnotics, alcoholism and unemployment.In a large clinical cohort with suspected OSA, controlling for confounders, OSA symptoms and severity were not related to the risk of hospitalisation for depression, suggesting that previously reported links between OSA and depression may be due to overlapping diagnostic criteria. However, our findings cannot exclude a potential link between OSA and milder depression.
Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter?
Authors: Derks Jules L. , van Suylen Robert Jan , Thunnissen Erik , den Bakker Michael A. , Groen Harry J. , Smit Egbert F. , Damhuis Ronald A. , van den Broek Esther C. , Speel Ernst-Jan M. , Dingemans Anne-Marie C. ,   PALGA group
Published: June 2017

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for metastatic LCNEC ranges from small cell lung carcinoma (SCLC) regimens to nonsmall cell lung carcinoma (NSCLC) chemotherapy regimens. We analysed outcomes of chemotherapy treatments for LCNEC.The Netherlands Cancer Registry and Netherlands Pathology Registry (PALGA) were searched for patients with stage IV chemotherapy-treated LCNEC (2003–2012). For 207 patients, histology slides were available for pathology panel review. First-line platinum-based combined chemotherapy was clustered as “NSCLC-t”, comprising gemcitabine, docetaxel, paclitaxel or vinorelbine; “NSCLC-pt”, with pemetrexed treatment only; and “SCLC-t”, consisting of etoposide chemotherapy.A panel review diagnosis of LCNEC was established in 128 out of 207 patients. NSCLC-t chemotherapy was administered in 46% (n=60), NSCLC-pt in 16% (n=20) and SCLC-t in 38% (n=48) of the patients. The median (95% CI) overall survival for NSCLC-t chemotherapy was 8.5 (7.0–9.9) months, significantly longer than patients treated with NSCLC-pt, with a median survival of 5.9 (5.0–6.9) months (hazard ratio 2.51, 95% CI 1.39–4.52; p=0.002) and patients treated with SCLC-t chemotherapy, with a median survival of 6.7 (5.0–8.5) months (hazard ratio 1.66, 95% CI 1.08–2.56; p=0.020).In patients with LCNEC, NSCLC-t chemotherapy results in longer overall survival compared to NSCLC-pt and SCLC-t chemotherapy.
The association between chronic airflow obstruction and poverty in 12 sites of the multinational BOLD study
Authors: Townend John , Minelli Cosetta , Mortimer Kevin , Obaseki Daniel O. , Al Ghobain Mohammed , Cherkaski Hamid , Denguezli Myriam , Gunesekera Kirthi , Hafizi Hasan , Koul Parvaiz A. , Loh Li C. , Nejjari Chakib , Patel Jaymini , Sooronbayev Talant , Buist Sonia A. , Burney Peter G.J. 
Published: June 2017

Poverty is strongly associated with mortality from COPD, but little is known of its relation to airflow obstruction.In a cross-sectional study of adults aged ≥40 years from 12 sites (N=9255), participating in the Burden of Obstructive Lung Disease (BOLD) study, poverty was evaluated using a wealth score (0–10) based on household assets. Obstruction, measured as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) (%) after administration of 200 μg salbutamol, and prevalence of FEV1/FVC<lower limit of normal were tested for association with poverty for each site, and the results were combined by meta-analysis.Mean wealth scores ranged from 4 in Blantyre (Malawi) and Kashmir (India) to 10 in Riyadh (Saudi Arabia), and the prevalence of obstruction, from 16% in Kashmir to 3% in Riyadh and Penang (Malaysia). Following adjustments for age and sex, FEV1/FVC increased by 0.36% (absolute change) (95%CI: 0.22, 0.49; p<0.001) per unit increase in wealth score. Adjustments for other confounders reduced this effect to 0.23% (0.11, 0.34), but even this value remained highly significant (p<0.001). Results were consistent across sites (I2=1%; phet=0.44). Mean wealth scores explained 38% of the variation in mean FEV1/FVC between sites (r2=0.385, p=0.031).Airflow obstruction is consistently associated with poverty at individual and community levels across several countries.
Pilbara rock art: laser scanning, photogrammetry and 3D photographic reconstruction as heritage management tools
Authors: Davis Annabelle , Belton David , Helmholz Petra , Bourke Paul , McDonald Jo 
Published: June 2017

Abstract
Recording techniques such as laser scanning, photogrammetry and photographic reconstruction are not new to archaeology. However as technology evolves and becomes more readily available such methods are being more regularly employed within a cultural heritage management context, often by people with little experience in using these technologies for heritage applications. For most cultural heritage management practitioners, the awe and lure of technology and the ease with which it can bring archaeology to life can distract from the end game of managing the site on the ground. This paper examines the advantages and disadvantages of laser scanning, photogrammetry and photographic reconstruction in recording, managing and interpreting rock art sites with an emphasis on its practical applications to the field of heritage management. Using a case study from West Angelas in the East Pilbara region of Western Australia, we will examine how these technologies assist in the practical management of heritage sites, and the significant outputs achieved for Aboriginal stakeholder groups in remote access to, and the interpretation of indigenous heritage sites.
HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Authors: Shah Manish A. , Xu Rui-hua , Bang Yung-Jue , Hoff Paulo M. , Liu Tianshu , Herráez-Baranda Luis A. , Xia Fan , Garg Amit , Shing Mona , Tabernero Josep 
Published: June 2017

Purpose To compare standard-of-care (SoC) trastuzumab plus chemotherapy with higher-dose (HD) trastuzumab plus chemotherapy to investigate whether HD trastuzumab increases trastuzumab serum trough concentration (Ctrough) levels and increases overall survival (OS) in first-line human epidermal growth factor receptor 2–positive metastatic gastric or gastroesophageal junction adenocarcinoma. Patients and Methods Patients with Eastern Cooperative Oncology Group performance status 2, no prior gastrectomy, and ≥ two metastatic sites were randomly assigned at a one-to-one ratio to loading-dose trastuzumab 8 mg/kg followed by SoC trastuzumab maintenance 6 mg/kg every 3 weeks or loading-dose trastuzumab 8 mg/kg followed by HD trastuzumab maintenance 10 mg/kg every 3 weeks until progression; treatment in each arm was combined with cisplatin 80 mg/m2 plus capecitabine 800 mg/m2 twice per day in cycles 1 to 6. The primary objective was HD trastuzumab OS superiority (all randomly assigned patients [full-analysis set]). Final results are from an interim analysis for futility (boundary hazard ratio [HR] ≥ 0.95) at 125 deaths. Results At clinical cutoff, 248 patients had been randomly assigned. A marked increase in mean trastuzumab Ctrough was observed after the first HD trastuzumab cycle versus SoC trastuzumab. In the full-analysis set, median OS was 12.5 months in the SoC trastuzumab arm and 10.6 months in the HD trastuzumab arm (stratified HR, 1.24; 95% CI, 0.86 to 1.78; P = .2401). Results were similar in the per-protocol set (cycle 1 trastuzumab Ctrough < 12 µg/mL). Safety was comparable between arms. Conclusion HD trastuzumab maintenance dosing was associated with higher trastuzumab concentrations, no increased efficacy, and no new safety signals. HELOISE confirms standard-dose trastuzumab (loading dose of 8 mg/kg followed by 6 mg/kg maintenance dose every 3 weeks) with chemotherapy as the SoC for first-line treatment of human epidermal growth factor receptor 2–positive metastatic gastric or gastroesophageal junction adenocarcinoma.
Neurologic Complications of Cardiac and Aortic Disease
Authors: Klaas James P. 
Published: June 2017

ABSTRACT

Purpose of Review: This article discusses neurologic complications that can arise from cardiac and aortic disease and dysfunction.

Recent Findings: Advances in the care of patients with cardiac or aortic disease include the use of prolonged cardiac monitoring in cryptogenic stroke and the approval of the use of left atrial appendage closure devices for stroke prevention in patients with atrial fibrillation who are not candidates for anticoagulation. Continuing controversy surrounds patent foramen ovale closure, and new evidence indicates that cognitive impairment following coronary artery bypass grafting surgery may be less common than previously thought.

Summary: Dysfunction of the cardiovascular system can cause serious neurologic injury. In some cases, both the initial presenting symptom and the most serious damage done by cardiac or aortic dysfunction may be neurologic. Prompt recognition of the symptoms, combined with recent advances in both cardiology and neurology, may permit more accurate diagnoses, more effective treatment, and less injury to patients.
Gastroenterology and Neurology
Authors: Pfeiffer Ronald F. 
Published: June 2017

ABSTRACT

Purpose of Review: Just as gastrointestinal dysfunction may develop in the setting of neurologic disease, neurologic dysfunction may become evident in the setting of gastrointestinal disease. This article describes the range of neurologic features that have been described in three primary gastrointestinal diseases: celiac disease and gluten-related disorders, inflammatory bowel disease, and Whipple disease. Particular emphasis is placed on the controversial and evolving clinical picture of neurologic dysfunction in disorders of gluten sensitivity.

Recent Findings: Gluten-related disorders, including both the traditional autoimmune-based celiac disease and the more recently recognized nonautoimmune, nonallergic gluten sensitivity, have been the source of much attention in both medical and lay publications. The possible association between Crohn disease and neurologic disorders also is receiving attention. The recognition that, although Whipple disease is an exceedingly rare disorder, a surprising percentage of the population may be asymptomatic stool carriers of the causative organism makes it important to always be cognizant of the disorder.

Summary: The range of neurologic dysfunction in gastrointestinal diseases is broad and spans the spectrum from peripheral to central processes. Peripheral neuropathy, myopathy, myelopathy, cerebrovascular events, epilepsy, encephalopathy, and cerebellar dysfunction have all been described. Neurologists should be aware of the possibility that an underlying gastrointestinal disease process may be present in and responsible for the neurologic dysfunction that has prompted referral of an individual for evaluation.
Zirconium-based Metal–Organic Frameworks with N-Confused Porphyrins: Synthesis, Structures, and Optical Properties
Authors: Yang Yufeng , Sakashita Ryuichi , Yamasumi Kazuhisa , Ishida Masatoshi , Yamada Teppei , Furuta Hiroyuki 
Published: June 2017

Abstract
Metal–organic frameworks (MOFs) composed of zirconium (Zr6) and N-confused porphyrins (NCPs) were synthesized. The cubic structures with ftw topology were determined by powder X-ray diffraction and microscopic analyses. These complexes represent high chemical stability toward various pH ranges and NIR absorption/emission derived from the NCP moieties.
Communication, Incentives, and the Execution of a Strategic Initiative
Authors: Hutchison-Krupat Jeremy 
Published: June 2017

Senior leadership has two primary levers to influence a direct report: incentives and communication. Financial incentives are credible and precisely specified but offer limited flexibility. In contrast, communication is flexible but lacks precision, and must be deemed credible to affect a direct report’s actions. We study a setting where senior leadership seeks to add a new initiative to their organization’s portfolio. The initiative’s potential to create value is not initially well understood. Senior leadership eventually obtains more precise information on the initiative’s value and subsequently may communicate this information to their direct report. We analyze senior leadership’s incentive and communication decisions, and ultimately their portfolio decision. We find that senior leadership’s communication only affects a direct report’s actions when a new initiative’s potential to create value is sufficiently uncertain. Additionally, we find instances where an organization may benefit from communication that offers lessspecificity. This paper was accepted by David Hsu, entrepreneurship and innovation.
Genes Associated with Thoracic Aortic Aneurysm and Dissection
Authors: Brownstein Adam , Ziganshin Bulat , Kuivaniemi Helena , Body Simon , Bale Allen , Elefteriades John 
Published: June 2017

AbstractThoracic aortic aneurysm (TAA) is a lethal disease, with a natural history of enlarging progressively until dissection or rupture occurs. Since the discovery almost 20 years ago that ascending TAAs are highly familial, our understanding of the genetics of thoracic aortic aneurysm and dissection (TAAD) has increased exponentially. At least 29 genes have been shown to be associated with the development of TAAD, the majority of which encode proteins involved in the extracellular matrix, smooth muscle cell contraction or metabolism, or the transforming growth factor-β signaling pathway. Almost one-quarter of TAAD patients have a mutation in one of these genes. In this review, we provide a summary of TAAD-associated genes, associated clinical features of the vasculature, and implications for surgical treatment of TAAD. With the widespread use of next-generation sequencing and development of novel functional assays, the future of the genetics of TAAD is bright, as both novel TAAD genes and variants within the genes will continue to be identified.
From the Editor in Chief
Authors: Doğanay Ahmet 
Published: June 2017

Değerli bilgi üretici ve tüketicileri,

Zaman hızla akıyor ve Pegem Eğitim ve Öğretim Dergisi'nin (PEGEGOG) yeni bir sayısıyla daha birlikteyiz. Her sayı yeni bir heyecan, yeni bir mutluluk katıyor bize. Ayrıca, siz değerli yazar, hakem ve okuyucularımızın her geçen gün artan destek ve katkılarıyla gittikçe güçleniyoruz. Bu gücümüzü en kısa sürede Üniversitelerarası Kurulca kabul edilen alan indekslerinden en az birine girerek taçlandırmak istiyoruz. Bu konuda sizlerden isteğimiz, hem kapsam ve yöntem açısından hem de şekilsel açıdan daha nitelikli çalışmalar yapmak.

Daha önceki sayımızda belirttiğim gibi, 2015 yılı eğitim bilimleri alanında ulusal ve uluslararası kongre ve sempozyumlar açısından oldukça verimli bir yıl olacağa benziyor. Bu bağlamda 16-18 Nisan 2015 tarihleri arasında Pegem Akademi ve Niğde Üniversitesi'nin katkıları ve işbirliğiyle 24. Ulusal Eğitim Bilimleri Kongresi gerçekleştirildi. Pegem Eğitim ve Öğretim Dergisi (PEGEGOG) olarak, kongreye destek veren çok sayıda ulusal eğitim dernekleri ve katılımcıların yoğun istekleriyle, bu kongrede sunulan bildirilerin yer alacağı bir özel sayı çıkarmayı kararlaştırdık. Bu özel sayı ile ilgili ayrıntılı açıklamayı siz değerli katılımcılara bir an önce ulaştırmayı planlıyoruz.

Daha önceki sayılarda yaptığım gibi bu sayıda da, dergimize gönderilen ya da kongre ve sempozyumlarda sunulan bildiri ve makalelerle ilgili gözlem ve deneyimlerimi paylaşmaya devam etmek istiyorum. Bu sayıda üzerinde durmak istediğim konu araştırma modeli. Bilindiği gibi bilimin dört temel işlevi bulunmaktadır. Bunlar, betimleme, açıklama, yordama ve kontroldür. Betimleme doğa ve toplumdaki değişkenleri belirleme, sınıflama ve özelliklerini ortaya koyma çabasıdır. Bu çaba her ne kadar bilimsel bir etkinlik sayılsa da olguların nedenlerinin de ortaya konulması gerekir. Bu ise bilimin açıklama işlevidir. Gözlemlediğim kadarıyla özellikle kongre ve sempozyumlarda daha çok bilimin betimleme işlevi doğrultusunda çalışmalar sunulmaktadır. Bilim aynı zamanda bir sorun çözme yoludur. Bilimsel çalışmaların karşılaşılan bir güçlüğü çözmesi ve böylelikle uygulayıcılara kolaylıklar sağlaması beklenir. Örneğin sınıflarda öğrencilerin karşılaştığı öğrenme güçlüklerinin belirlenmesi betimsel bir çalışmayı gerektirmektedir. Sınıflarda öğrenme güçlüğü ile ilgili karşılaşılan sorunların betimlenmesinin sorunun çözümüne önemli bir katkısı yoktur. Eğer belirlenen bu sorunlar bir eylem araştırması yoluyla çözümlenmeye çalışılırsa, sorunların betimlenmesi önem kazanır. Bu nedenle, eğer betimsel bir çalışma planlanıyorsa daha sonra izleme araştırmalarıyla belirlenen sorunun çözümüne yönelik araştırmaların yapılmasının gereği açıktır. Böylelikle bilimin topluma daha fazla yararı olacaktır.

Bu sayıda her zaman olduğu gibi, hakem değerlendirme süreci tamamlanan ve daha önce doi numarası verilen altı makale yer almaktadır. Eğitim bilimlerinin çeşitli alanlarında yapılan bu çalışmaların siz değerli bilgi üretici ve tüketicilerine yararlı olmasını ve eğitim uygulamalarına katkı yapmasını diliyor, gelecek sayıda buluşmak dileğiyle en içten saygılarımı sunuyorum.
Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
Authors: Dielievska V. , Kravchun P. 
Published: June 2017

Abstract
Patients with chronic obstructive pulmonary disease (COPD) have high risk of cardiovascular events due to the remodeling of the heart and vessels. We investigated whether in COPD cardiac remodeling is associated with immune response to the inflammation by studying activated T-lymphocytes, CD3+, CD4+, CD8+ subsets of T-lymphocytes autoimmune lymphocytotoxic and granulocytotoxic antibodies, circulating immune complexes, bacterial sensibilization and hypersensitivity by the delayed type to the host heart tissue antigens. It turned out that progression of COPD is characterized by the decrease of cell immunity with formation of bacterial sensibilization and autosensibilization to the heart tissue antigens, strongly associated with cardiac remodeling. Thus, the presence of autoimmune response significantly contributes to the changes of heart geometry in patients with COPD.
Psychological Well-being among Postgraduate Students
Authors: Roslan S. , Ahmad N. , Nabilla N. , Ghiami Z. 
Published: June 2017

Abstract
This study attempted to determine the level of psychological well-being among postgraduate students. The study also aimed to assess the relationship between psychological well-being and demographic factors, such as age and field of study. Psychological well-being questionnaires were administered to a sample of 192 Master of Education students. The findings demonstrated that Master of Education students possessed a slightly high level of psychological well-being. Differences were found in students’ psychological well-being across age groups, F (4, 167) = 3.178, p = 0.01, and field of study, F (8, 163) = 2.668, p = 0.01, respectively. According to the results, students in the age group of 41 years and above possessed the highest level of psychological well-being (M = 5, SD = 0.71).
The elliptic sinh-Gordon equation in a semi-strip
Authors: Hwang Guenbo 
Published: June 2017

Abstract
We study the elliptic sinh-Gordon equation posed in a
semi-strip by applying the so-called Fokas method, a
generalization of the inverse scattering transform for boundary
value problems. Based on the spectral analysis for the Lax pair
formulation, we show that the spectral functions can be
characterized from the boundary values.
We express the solution of the equation
in terms of the unique solution of the matrix Riemann–Hilbert problem
whose jump matrices are defined by the
spectral functions. Moreover, we
derive the global algebraic relation that involves the boundary
values. In addition, it can be verified that the solution of the
elliptic sinh-Gordon equation posed in the semi-strip exists if
the spectral functions defined by the boundary values satisfy this
global relation.
Orphan Disease in Structure of Recurrent Lower Respiratory Tract Diseases in Children from One To Five
Authors: Zubarenko O. V. , Koval Larisa , Doykova Katherina , Kopiyka Ganna , Skrypnyk V. V. , Lotysh Nadiya , Papinko R. M. 
Published: June 2017

Abstract
The paper contains structure analysis of the lower respiratory tract recurrent disease in 180 children aged one to five years, residents of Odessa, who were treated in pulmonology department of Children’s Academician BJ Reznik City Clinical Hospital.
The examinees are represented by two groups: 150 children with recurrent wheezing and 30 - with recurrent pneumonia. The selection criteria were: abnormality of central nervous system, abnormality, cystic fibrosis, congenital heart defects, tuberculosis, human immunodeficiency virus-infection.
The analysis detected that in the survey sample with recurrent lower respiratory tract disease 3.88% of children had Orphan disease. Thus in the group of children with recurrent wheezing were diagnosed 2 cases of congenital lobar hyperexpansion (ORPHA 1928), one case of lung bronchogenic cyst (ORPHA 2357), one case of pulmonary hypoplasia in the lower lobe of the left lung (ORPHA 2257), and one case of primary ciliary dyskinesia (ORPHA 98,861).
Regarding the entire structure of recurrent wheezing, most frequently was detected atopic asthma (49.33%). In 24.6% cases the cause of recurrent wheezing was associated with the otolaryngological pathology. Bronchopulmonary dysplasia was diagnosed in two children.
Recurrent pneumonia cases were differentiated if the localization of process was at the same or different places. When one-sided localization of pneumonia was established, next congenital airway malformations were diagnosed - 3 cases of congenital cystic adenomatoid malformations (type I). Genetic pathology often occurred in cases with different lesions location.
In all cases of uncertain diagnosis, predictors of recurrent lower respiratory tract diseases were revealed.
Clinical and Morphopathological Considerations in Pulmonary Hydatid Cyst Complicated by Endobronchial Rupture in Children
Authors: Dogotari N. , Gudumac Eva , Tica C. , Eremia V. , Ionescu C. , Babuci S. 
Published: June 2017

Abstract
The authors present a clinical case that aims to elucidate the diagnostic tactics and the efficiency of the chystostomy procedure performed in children with complicated endobronchial lung hydatid cyst and the potential serious postoperative complications that may occur in the case of this non-capitonary residual cavity technique after pulmonary echinococectomy.
Faced with the clinical, surgical and morphopathological investigations of the endobronchus ruptured lung hydatid cyst, the authors conclude that the spectra of morphological pathogenesis present in these cases are responsible for the development of persistent aerostatic disorder, resulting in a long-term postoperative morbidity, which confirms the need to optimize the methods of surgical correction of postechinococectomial residual cavities.