bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of motor behavior
Authors: Adolph Karen E. , Franchak John M. 
Published: December 2016

This article reviews research on the development of motor behavior from a developmental systems perspective. We focus on infancy when basic action systems are acquired. Posture provides a stable base for locomotion, manual actions, and facial actions. Experience facilitates improvements in motor behavior and infants accumulate immense amounts of experience with all of their basic action systems. At every point in development, perception guides motor behavior by providing feedback about the results of just prior movements and information about what to do next. Reciprocally, the development of motor behavior provides fodder for perception. More generally, motor development brings about new opportunities for acquiring knowledge about the world, and burgeoning motor skills can instigate cascades of developmental changes in perceptual, cognitive, and social domains.WIREs Cogn Sci2017, 8:e1430. doi: 10.1002/wcs.1430This article is categorized under:Psychology > Development and AgingPsychology > Motor Skill and Performance
Diagnosis and Treatment of Testosterone Deficiency: Recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015)
Authors: Khera Mohit , Adaikan Ganesh , Buvat Jacques , Carrier Serge , El-Meliegy Amr , Hatzimouratidis Kostas , McCullough Andrew , Morgentaler Abraham , Torres Luiz Otavio , Salonia Andrea 
Published: December 2016

ABSTRACTIntroductionTestosterone deficiency (TD), also known as hypogonadism, is a condition affecting a substantial proportion of men as they age. The diagnosis and management of TD can be challenging and clinicians should be aware of the current literature on this condition.AimTo review the available literature concerning the diagnosis and management of TD and to provide clinically relevant recommendations from the Fourth International Consultation for Sexual Medicine (ICSM) meeting.MethodsA literature search was performed using the PubMed database for English-language original and review articles published or e-published up to January 2016.Main Outcome MeasuresLevels of evidence (LoEs) and grades of recommendations are provided based on a thorough analysis of the literature and committee consensus.ResultsRecommendations were given for 12 categories of TD: definition, clinical diagnosis, routine measurement, screening questionnaires, laboratory diagnosis, threshold levels for the biochemical diagnosis of TD, prostate cancer, cardiovascular disease, fertility, testosterone (T) formulations, alternatives to T therapy, and adverse events and monitoring. A total of 42 recommendations were made: of these, 16 were unchanged from the Third ICSM and 26 new recommendations were made during this Fourth ICSM. Most of these recommendations were supported by LoEs 2 and 3. Several key new recommendations include the following: (i) the clinical manifestations of TD occur as a result of decreased serum androgen concentrations or activity, regardless of whether there is an identified underlying etiology [LoE = 1, Grade = A]; (ii) symptomatic men with total T levels lower than 12 nmol/L or 350 ng/dL should be treated with T therapy [LoE = 1, Grade = C]; (iii) a trial of T therapy in symptomatic men with total T levels higher than 12 nmol/L or 350 ng/dL can be considered based on clinical presentation [LoE = 3, Grade = C]; (iv) there is no compelling evidence that T treatment increases the risk of developing prostate cancer or that its use is associated with prostate cancer progression [LoE = 1, Grade = C]; and (v) the weight of evidence indicates that T therapy is not associated with increased cardiovascular risk [LoE = 2, Grade = B].ConclusionTD is an important condition that can profoundly affect the sexual health of men. We provide guidance regarding its diagnosis and management. Men with TD who receive treatment often experience resolution or improvement in their sexual symptoms and non-sexual health benefits.
THE DEFINABILITY STRENGTH OF COMBINATORIAL PRINCIPLES
Authors: WANG WEI 
Published: December 2016

AbstractWe introduce the definability strength of combinatorial principles. In terms of definability strength, a combinatorial principle is strong if solving a corresponding combinatorial problem could help in simplifying the definition of a definable set. We prove that some consequences of Ramsey’s Theorem for colorings of pairs could help in simplifying the definitions of some ${\rm{\Delta }}_2^0$ sets, while some others could not. We also investigate some consequences of Ramsey’s Theorem for colorings of longer tuples. These results of definability strength have some interesting consequences in reverse mathematics, including strengthening of known theorems in a more uniform way and also new theorems.
THE REDUCTS OF THE HOMOGENEOUS BINARY BRANCHING C-RELATION
Authors: BODIRSKY MANUEL , JONSSON PETER , VAN PHAM TRUNG 
Published: December 2016

AbstractLet ($\rm L$;C) be the (up to isomorphism unique) countable homogeneous structure carrying a binary branching C-relation. We study the reducts of ($\rm L$;C), i.e., the structures with domain $\rm L$ that are first-order definable in ($\rm L$;C). We show that up to existential interdefinability, there are finitely many such reducts. This implies that there are finitely many reducts up to first-order interdefinability, thus confirming a conjecture of Simon Thomas for the special case of ($\rm L$;C). We also study the endomorphism monoids of such reducts and show that they fall into four categories.
Reproductive ecology of phorid parasitoids in relation to the head size of leaf-cutting antsAtta sexdensForel
Authors: Farder-Gomes C.F. , Oliveira M.A. , Gonçalves P.L. , Gontijo L.M. , Zanuncio J.C. , Bragança M.A.L. , Pires E.M. 
Published: December 2016

AbstractThe leaf-cutting antAtta sexdensForel (Hymenoptera: Formicidae) is one of the most damaging agricultural pests in the Neotropics. Management strategies predominantly rely on the use of general insecticides. What is needed are more species-specific and environmentally friendly options. Parasitioids such as phorid flies (Diptera: Phoridae) may be one such option, but a greater understanding of the ecology of the flies and their ant hosts is essential to devise biological control strategies. Here we report parasitism rates, ant host size, parasitoid abundance per host and resultant sex ratios of two phorid speciesApocephalus attophilusBorgmeier andEibesfeldtphora tonhascaiBrown parasitizingA.sexdens. The two species achieved parasitism rates of 1.48 and 1.46%, respectively and the pupal period was 14.7 ± 1.1 days and 22.1 ± 2.8 days, respectively. There was no significant difference between the head capsule width of ants parasitized by eitherA. attophilusorE. tonhascai. Likewise, there was no significant effect between the head capsule width of parasitized and unparasitized ants for both species. A significant positive correlation was found between the head capsule width of the parasitized ants and the number of adult parasitoidsA. attophilusemerged. Ants parasitized byE. tonhascaisurvived significantly longer than those parasitized byA. attophilus. There was no significant effect of ant head width on the sex ratio of the offspring of either parasitoid species and no significant difference in the sex ratio (male: female) of their offspring. In summary, these data addressed here are important steps when considering natural enemies for biological control. Studying survival of the parasitized ants, parasitoid offspring sex ratio and host size preference allows for a better understanding of ant natural biological control in the field and can help in rearing ofA. attophilusandE. tonhascaiin laboratory.
The Role of the State in Employment and Welfare Regulation: Sweden in the European Context
Authors: Koch Max 
Published: December 2016

AbstractThis article examines the changing role of the Swedish state in employment and welfare regulation in an environment that has become more market driven, commodified, and Europeanized. It begins with a theoretical reflection on the role of the state in capitalist development and a review of the recent debate on the spatiality of state regulation: the state as employer, redistributor, and arbiter, and as a shaper of employment relations and welfare. In the latter role, the state is conceptualized as employer, guarantor of employment rights, and procedural regulator, as intermediating neo-corporatist processes, as macroeconomic manager, and as welfare state. From this theoretical basis, the paper identifies changes in state employment and welfare regulation by comparing two periods: the original and mainly nation-state-based founding stage of the Swedish welfare and employment model as it developed after the 1938 Saltsjöbaden Agreement, and the period after Sweden’s accession to the European Union in 1995.
Tributary Labour in the Russian Empire in the Eighteenth Century: Factors in Development
Authors: Khitrov Dmitry 
Published: December 2016

AbstractThis article addresses the system of state-organized and state-controlled tributary labour in the Russian Empire in the eighteenth century. On the basis of the taxpayers’ registry of 1795, it focuses on the social groups obliged to perform military service or labour directly for the polity. They included the numerous “service class” of the southern and eastern frontier regions, including Russian, Ukrainian (mainly Cossack), and indigenous (Bashkir and Kalmyk) communities, and the group of pripisnye, peasants “bound” to industries and shipyards to work for their taxes. The rationale behind the use of this type of labour relation was, on the one hand, the need of the state to secure the support of labour in distant and poorly populated regions, and, on the other, that the communes of labourers saw performing work for the state as a strong guarantee of their landowning privileges.
Robert Leiper and the London School of (Hygiene and) Tropical Medicine
Authors: COX FRANCIS E. G. 
Published: December 2016

SUMMARYRobert Leiper is best known for his discoveries in the fields of Guinea worm and schistosomiasis, but he also made major contributions to parasitology during his career as helminthologist and later Professor of Helminthology at the London School of (Hygiene and) Tropical Medicine. He was particularly involved in establishing the London School's Winches Farm Field Station and stimulating the research carried out there, work that has made a number of important contributions to our understanding of parasites. Leiper founded the Commonwealth Bureau of Agricultural Parasitology and was also instrumental in initiating, and editing, the Journal of Helminthology, Helminthological Abstracts and establishing, indirectly, Protozoological Abstracts.
Characterizing areas of potential human exposure to eastern equine encephalitis virus using serological and clinical data from horses
Authors: ROCHELEAU J.-P. , ARSENAULT J. , OGDEN N. H. , LINDSAY L. R. , DREBOT M. , MICHEL P. 
Published: December 2016

SUMMARYEastern equine encephalitis (EEE) is a rare but severe emerging vector-borne disease affecting human and animal populations in the northeastern United States where it is endemic. Key knowledge gaps remain about the epidemiology of EEE virus (EEEV) in areas where its emergence has more recently been reported. In Eastern Canada, viral activity has been recorded in mosquitoes and horses throughout the 2000s but cases of EEEV in humans have not been reported so far. This study was designed to provide an assessment of possible EEEV human exposure by modelling environmental risk factors for EEEV in horses, identifying high-risk environments and mapping risk in the province of Quebec, Canada. According to logistic models, being located near wooded swamps was a risk factor for seropositivity or disease in horses [odds ratio (OR) 4·15, 95% confidence interval (CI) 1·16–14·8) whereas being located on agricultural lands was identified as protective (OR 0·75, 95% CI 0·62–0·92). A better understanding of the environmental risk of exposure to EEEV in Canada provides veterinary and public health officials with enhanced means to more effectively monitor the emergence of this public health risk and design targeted surveillance and preventive measures.
Joint spatial time-series epidemiological analysis of malaria and cutaneous leishmaniasis infection
Authors: ADEGBOYE O. A. , AL-SAGHIR M. , LEUNG D. H. Y. 
Published: December 2016

SUMMARYMalaria and leishmaniasis are among the two most important health problems of many developing countries especially in the Middle East and North Africa. It is common for vector-borne infectious diseases to have similar hotspots which may be attributed to the overlapping ecological distribution of the vector. Hotspot analyses were conducted to simultaneously detect the location of local hotspots and test their statistical significance. Spatial scan statistics were used to detect and test hotspots of malaria and cutaneous leishmaniasis (CL) in Afghanistan in 2009. A multivariate negative binomial model was used to simultaneously assess the effects of environmental variables on malaria and CL. In addition to the dependency between malaria and CL disease counts, spatial and temporal information were also incorporated in the model. Results indicated that malaria and CL incidence peaked at the same periods. Two hotspots were detected for malaria and three for CL. The findings in the current study show an association between the incidence of malaria and CL in the studied areas of Afghanistan. The incidence of CL disease in a given month is linked with the incidence of malaria in the previous month. Co-existence of malaria and CL within the same geographical area was supported by this study, highlighting the presence and effects of environmental variables such as temperature and precipitation. People living in areas with malaria are at increased risk for leishmaniasis infection. Local healthcare authorities should consider the co-infection problem by recommending systematic malaria screening for all CL patients.
Computerized Cognitive Tests Are Associated with Biomarkers of Alzheimer’s Disease in Cognitively Normal Individuals 10 Years Prior
Authors: Soldan Anja , Pettigrew Corinne , Moghekar Abhay , Albert Marilyn ,   the BIOCARD Research Team
Published: December 2016

AbstractObjectives: Evidence suggests that Alzheimer’s disease (AD) biomarkers become abnormal many years before the emergence of clinical symptoms of AD, raising the possibility that biomarker levels measured in cognitively normal individuals would be associated with cognitive performance many years later. This study examined whether performance on computerized cognitive tests is associated with levels of cerebrospinal fluid (CSF) biomarkers of amyloid, tau, and phosphorylated tau (p-tau) obtained approximately 10 years earlier, when individuals were cognitively normal and primarily middle-aged. Methods: Individuals from the BIOCARD cohort (mean age at testing=69 years) were tested on two computerized tasks hypothesized to rely on brain regions affected by the early accumulation of AD pathology: (1) a Paired Associates Learning (PAL) task (n=67) and (2) a visual search task (n=86). Results: In regression analyses, poorer performance on the PAL task was associated with higher levels of CSF p-tau obtained years earlier, whereas worse performance in the visual search task was associated with lower levels of CSF Aβ1-42. Conclusions: These findings suggest that AD biomarker levels may be differentially predictive of specific cognitive functions many years later. In line with the pattern of early accumulation of AD pathology, the PAL task, hypothesized to rely on medial temporal lobe function, was associated with CSF p-tau, whereas the visual search task, hypothesized to rely on frontoparietal function, was associated with CSF amyloid. Studies using amyloid and tau PET imaging will be useful in examining these hypothesized relationships further. (JINS, 2016, 22, 968–977)
Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer’s Disease
Authors: Lancaster Melissa A. , Seidenberg Michael , Smith J. Carson , Nielson Kristy A. , Woodard John L. , Durgerian Sally , Rao Stephen M. 
Published: December 2016

AbstractObjectives:White matter (WM) integrity within the mesial temporal lobe (MTL) is important for episodic memory (EM) functioning. The current study investigated the ability of diffusion tensor imaging (DTI) in MTL WM tracts to predict 3-year changes in EM performance in healthy elders at disproportionately higher genetic risk for Alzheimer’s disease (AD).Methods:Fifty-one cognitively intact elders (52% with family history (FH) of dementia and 33% possessing an Apolipoprotein E ε4 allelle) were administered the Rey Auditory Verbal Learning Test (RAVLT) at study entry and at 3-year follow-up. DTI scanning, conducted at study entry, examined fractional anisotropy and mean, radial and axial diffusion within three MTL WM tracts: uncinate fasciculus (UNC), cingulate-hippocampal (CHG), and fornix-stria terminalis (FxS). Correlations were performed between residualized change scores computed from RAVLT trials 1–5, immediate recall, and delayed recall scores and baseline DTI measures; MTL gray matter (GM) and WM volumes; demographics; and AD genetic and metabolic risk factors.Results:Higher MTL mean and axial diffusivity at baseline significantly predicted 3-year changes in EM, whereas baseline MTL GM and WM volumes, FH, and metabolic risk factors did not. Both ε4 status and DTI correlated with change in immediate recall.Conclusions:Longitudinal EM changes in cognitively intact, healthy elders can be predicted by disruption of the MTL WM microstructure. These results are derived from a sample with a disproportionately higher genetic risk for AD, suggesting that the observed WM disruption in MTL pathways may be related to early neuropathological changes associated with the preclinical stage of AD. (JINS, 2016,22, 1005–1015)
‘Pesky gNATs’: investigating the feasibility of a novel computerized CBT intervention for adolescents with anxiety and/or depression in a Tier 3 CAMHS setting
Authors: Chapman Rosanna , Loades Maria , O'Reilly Gary , Coyle David , Patterson Mags , Salkovskis Paul 
Published: December 2016

AbstractIncreasingly, evidence suggests that computerized Cognitive Behavioural Therapy (cCBT) is effective at reducing adolescent anxiety and depression for young people in the general population or those ‘at risk’. However, less is known about the acceptability, feasibility and effectiveness of cCBT for adolescents with clinically significant levels of impairment. This study aimed to investigate the feasibility of using a novel cCBT intervention, ‘Pesky gNATs’, with adolescents aged between 13–18 years with anxiety and/or depression who met the criteria for specialist mental health services. Eleven participants were recruited from a Tier 3 child and adolescent mental health service (CAMHS). Recruitment, attendance and retention rates were recorded and qualitative feedback about the benefits and disadvantages of completing cCBT were obtained during the final session. In addition, a number of outcome measures were completed pre- and post- intervention to assess reliable and clinically significant change. The intervention was very brief comprising of just seven sessions. Participants showed high recruitment and retention rates. All participants who started the intervention completed it. All described the programme as useful and the majority identified several benefits. Four of 11 participants demonstrated reliable reductions in symptoms of depression and anxiety and six of 11 showed decreases in parent-reported symptoms of anxiety and depression following the seven-session intervention. This study demonstrates the acceptability and feasibility of using cCBT in a Tier 3 CAMHS setting. Further research is required to investigate the effect of Pesky gNATs on anxiety and depression in other Tier 3 settings.
Large-scale pharmacological profiling of 3D tumor models of cancer cells
Authors: Mathews Griner Lesley A , Zhang Xiaohu , Guha Rajarshi , McKnight Crystal , Goldlust Ian S , Lal-Nag Madhu , Wilson Kelli , Michael Sam , Titus Steve , Shinn Paul , Thomas Craig J , Ferrer Marc 
Published: December 2016

AbstractThe discovery of chemotherapeutic agents for the treatment of cancer commonly uses cell proliferation assays in which cells grow as two-dimensional (2D) monolayers. Compounds identified using 2D monolayer assays often fail to advance during clinical development, most likely because these assays do not reproduce the cellular complexity of tumors and their microenvironment in vivo. The use of three-dimensional (3D) cellular systems have been explored as enabling more predictive in vitro tumor models for drug discovery. To date, small-scale screens have demonstrated that pharmacological responses tend to differ between 2D and 3D cancer cell growth models. However, the limited scope of screens using 3D models has not provided a clear delineation of the cellular pathways and processes that differentially regulate cell survival and death in the different in vitro tumor models. Here we sought to further understand the differences in pharmacological responses between cancer tumor cells grown in different conditions by profiling a large collection of 1912 chemotherapeutic agents. We compared pharmacological responses obtained from cells cultured in traditional 2D monolayer conditions with those responses obtained from cells forming spheres versus cells already in 3D spheres. The target annotation of the compound library screened enabled the identification of those key cellular pathways and processes that when modulated by drugs induced cell death in all growth conditions or selectively in the different cell growth models. In addition, we also show that many of the compounds targeting these key cellular functions can be combined to produce synergistic cytotoxic effects, which in many cases differ in the magnitude of their synergism depending on the cellular model and cell type. The results from this work provide a high-throughput screening framework to profile the responses of drugs both as single agents and in pairwise combinations in 3D sphere models of cancer cells.
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer
Authors: Wang Xiao , Liang Zhen , Xu Xin , Li Jiangfeng , Zhu Yi , Meng Shuai , Li Shiqi , Wang Song , Xie Bo , Ji Alin , Liu Ben , Zheng Xiangyi , Xie Liping 
Published: December 2016

AbstractmiR-148a-3p downregulation has emerged as a critical factor in cancer progression yet, the underlying mechanisms of miR-148a-3p expression pattern and its function in bladder cancer remains to be elucidated. Here, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may be regulated by DNA methylation. DNA methyltransferase 1 (DNMT1) and miR-148a-3p function in a positive feedback loop in bladder cancer. miR-148a-3p overexpression functions as a tumor suppressor in bladder cancer cells. miR-148a-3p inhibits bladder cancer cell proliferation and epithelial–mesenchymal transition (EMT) by regulating ERBB3/AKT2/c-myc and ERBB3/AKT2/Snail signaling. ERBB3, DNMT1 and AKT2 are downstream miR-148a-3p target genes. Furthermore, the miR-148a-3p/ERBB3/AKT2/c-myc signaling axis establishes a positive feedback loop in the regulation of bladder cancer. Taken together, our study demonstrates novel regulatory circuits involving miR-148a-3p/ERBB3/AKT2/c-myc and DNMT1 that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.