bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sonochemical Synthesis of Sulfur Doped Reduced Graphene Oxide Supported CuS Nanoparticles for the Non-Enzymatic Glucose Sensor Applications
Authors: Karikalan Natarajan , Karthik Raj , Chen Shen-Ming , Karuppiah Chelladurai , Elangovan Arumugam 
Published: May 2017

AbstractOver the present material synthesis routes, the sonochemical route is highly efficient and comfortable way to produce nanostructured materials. In this way, the copper sulfide (CuS-covellite) and sulfur doped reduced graphene oxide (S-rGO) nanocomposite was prepared by sonochemical method. Interestingly, the structure of the as-prepared S-rGO/CuS was changed from the covellite to digenite phase. Herein, the S-rGO was act as a mild oxidizer and liable for the structural transformations. These structural changes are sequentially studied by various physicochemical characterizations such as Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Transmission electron microscopy (TEM). After scrupulous structural evaluations, the transformation of CuS phase was identified and documented. This oxidized CuS has an excellent electrocatalytic activity when compare to the bulk CuS. This S-rGO/CuS was further used for the determination of glucose and acquired good electrocatalytic performances. This S-rGO/CuS was exhibited a wide linear concentration range, 0.0001–3.88 mM and 3.88–20.17 mM, and a low-level detection limit of 32 nM. Moreover, we have validated the practicability of our developed glucose sensor in real biological samples.
Can plume-induced internal gravity waves regulate the core rotation of subgiant stars?
Authors: Pinçon C. , Belkacem K. , Goupil M. J. , Marques J. P. 
Published: May 2017

Context.The seismic data provided by the space-borne missions CoRoT andKeplerenabled us to probe the internal rotation of thousands of evolved low-mass stars. Subsequently, several studies showed that current stellar evolution codes are unable to reproduce the low core rotation rates observed in these stars. These results indicate that an additional angular momentum transport process is necessary to counteract the spin up due to the core contraction during the post-main sequence evolution. For several candidates, the transport induced by internal gravity waves (IGW) could play a non-negligible role.Aims.We aim to investigate the effect of IGW generated by penetrative convection on the internal rotation of low-mass stars from the subgiant branch to the beginning of the red giant branch.Methods.A semi-analytical excitation model was used to estimate the angular momentum wave flux. The characteristic timescale associated with the angular momentum transport by IGW was computed and compared to the contraction timescale throughout the radiative region of stellar models at different evolutionary stages.Results.We show that IGW can efficiently counteract the contraction-driven spin up of the core of subgiant stars if the amplitude of the radial-differential rotation (between the center of the star and the top of the radiative zone) is higher than a threshold value. This threshold depends on the evolutionary stage and is comparable to the differential rotation rates inferred for a sample of subgiant stars observed by the satelliteKepler. Such an agreement can therefore be interpreted as the consequence of a regulation mechanism driven by IGW. This result is obtained under the assumption of a smooth rotation profile in the radiative region and holds true even if a wide range of values is considered for the parameters of the generation model. In contrast, on the red giant branch, we find that IGW remain insufficient, on their own, to explain the observations because of an excessive radiative damping.Conclusions.IGW generated by penetrative convection are able to efficiently extract angular momentum from the core of stars on the subgiant branch and accordingly have to be taken into account. Moreover, agreements with the observations reinforce the idea that their effect is essential to regulate the amplitude of the radial-differential rotation in subgiant stars. On the red giant branch, another transport mechanism must likely be invoked.
Open Carpal Tunnel Release Outcomes: Performed Wide Awake versus with Sedation
Authors: Kim Nayoung , Abboudi Jack , Jones Christopher , Liss Frederic , Kirkpatrick William , Rivlin Michael , Wang Mark , Matzon Jonas , Ilyas Asif , Tulipan Jacob 
Published: May 2017

Background Carpal tunnel release (CTR) is the most common surgery of the hand, and interest is growing in performing it under local anesthesia without tourniquet. To better understand differences, we hypothesized that patients undergoing CTR under wide-awake local anesthesia with no tourniquet (WALANT) versus sedation (monitored anesthesia care [MAC]) would not result in a difference in outcome.
Methods Consecutive cases of electrodiagnostically confirmed open CTR across multiple surgeons at a single center were prospectively enrolled. Data included demographic data, visual analog scale, Levine-Katz carpal tunnel syndrome scale, QuickDASH questionnaire, customized Likert questionnaire, and complications.
Results There were 81 patients enrolled in the WALANT group and 149 patients in the MAC group. There were no reoperations in either group or any epinephrine-related complications in the WALANT group. Disability and symptom scores did not differ significantly between WALANT and sedation groups at 2 weeks or 3 months. Average postoperative QuickDASH, Levine-Katz, and VAS pain scales were the same in both groups. Both groups of patients reported high levels of satisfaction at 91 versus 96% for the WALANT versus MAC groups, respectively (p > 0.05). Patients in each group were likely to request similar anesthesia if they were to undergo surgery again.
Conclusion Patients undergoing open CTR experienced similar levels of satisfaction and outcomes with either the WALANT or MAC techniques. There was no statistically significant difference between either group relative to the tested outcome measures. These data should facilitate surgeons and patients' choosing freely between WALANT and MAC techniques relative to complications and outcomes.
Different Kinematics of Knees with Varus and Valgus Deformities
Authors: Benditz A. , Koeck F. , Keshmiri A. , Grifka J. , Maderbacher G. , Baier C. 
Published: May 2017

AbstractFew data exist of kinematics of knees with varus and valgus deformities combined with osteoarthritis. The purpose of this study was to reveal different (1) tibiofemoral kinematics, (2) medial and lateral gaps, and (3) condylar liftoff of osteoarthritic knees with either varus or valgus deformity before and after total knee arthroplasty (TKA). For this purpose, 40 patients for TKA were included in this study, 23 knees with varus deformity and 17 knees with valgus deformity. All patients underwent computer navigation, and kinematics was assessed before making any cuts or releases and after implantation. Osteoarthritic knees with valgus deformity showed a significant difference in tibia rotation relative to the femur with flexion before and after TKA, whereas knees with varus deformity did not. Knees with a valgus deformity showed femoral external rotation in extension and femoral internal rotation in flexion, whereas knees with a varus deformity revealed femoral internal rotation in extension and femoral external rotation in flexion. In both groups, gaps increased after TKA. Condylar liftoff was not observed in the varus deformity group after TKA. In the valgus deformity group, condylar liftoff was detected after TKA at knee flexion of 50 degrees and more. This study revealed significant differences in tibiofemoral kinematics between osteoarthritic knees with a varus or valgus deformity before and after TKA. Valgus deformities showed a paradoxic movement pattern. These in vivo intraoperative results need to be confirmed using fluoroscopic or radiographic three-dimensional matching before and after TKA.
Präoperative Vorbereitung: Patient Blood Management – Was ist optimal?
Authors: Meybohm Patrick , Müller Markus , Zacharowski Kai 
Published: May 2017

ZusammenfassungPatient Blood Management (PBM) fokussiert auf ein umfassendes Anämiemanagement, die Minimierung (unnötiger) iatrogener Blutverluste und die Ausschöpfung der natürlichen Anämietoleranz mit rationalem Einsatz von Erythrozytenkonzentrat-Transfusionen. Im Mittelpunkt des aktuellen Beitrags stehen die in der präoperativen Phase entscheidenden PBM-Komponenten: Management einer Anämie, prätransfusionelle Vorbereitungen und Management von Antikoagulanzien. Die präoperative Anämie ist ein unabhängiger Risikofaktor für eine erhöhte perioperative Morbidität und Sterblichkeit. Zum frühestmöglichen Zeitpunkt sollte daher vor elektiven Eingriffen die Ursachen der Anämie abgeklärt und bei behandelbaren Ursachen der Anämie eine spezifische Behandlung eingeleitet werden. Die präoperative prätransfusionelle Analytik sollte in Abhängigkeit von der Transfusionswahrscheinlichkeit (und dem Ausgangshämoglobinwert) einem Stufenkonzept folgen und aktuelle hausinterne Daten berücksichtigen. Im Umgang mit (oralen) Antikoagulanzien sollte bereits in der präoperativen Phase eine individuelle Risikostratifizierung erfolgen. Anhand des individuellen Blutungs- und Thromboembolierisikos wird sodann entschieden, ob die Medikation fortgeführt, pausiert oder überbrückt werden muss. Ohne klar definierte Verantwortlichkeiten im präoperativen PBM-Team, Kommunikation und Schulung aller Beteiligten ist langfristig kein Erfolg des präoperativen PBM-Programms zu erwarten.
Effects of Alternative Food Types on Body Size and Survival of Hatchery-Reared Lake Sturgeon Larvae
Authors: Valentine Shaley A , Bauman John M , Scribner Kim T 
Published: May 2017

Abstract
Aquaculture programs benefit from feeding protocols that result in large larval body size and high survival. Despite high labor, processing, and material costs relative to alternative foods, feeding live foods generally results in high larval growth and survival. For many species, studies that identify alternative food types or feeding regimens that produce larvae with high survival and size comparable with wild cohorts are lacking. In a 35-d study, the effects of alternative food types (previously frozen Artemia and trout crumble starter diet (trout diet) on TL, weight per fish, and survival of larval Lake Sturgeon Acipenser fulvescens were quantified. From days 14 to 21 postexogenous feeding, larvae were transitioned from live Artemia to one of the alternative food types or remained feeding on live Artemia as the control. At the end of the study, TL and weight per fish of larvae fed live Artemia were significantly greater than larvae fed the alternative foods. Survival of larvae fed live or frozen Artemia was higher than larvae fed the trout diet. Lower body growth and survival of larvae fed the alternative foods demonstrate that the frozen and formulated foods are not appropriate diets for Lake Sturgeon larvae.
Differences in responses to X-ray exposure between osteoclast and osteoblast cells
Authors: Zhang Jian , Wang Ziyang , Wu Anqing , Nie Jing , Pei Hailong , Hu Wentao , Wang Bing , Shang Peng , Li Bingyan , Zhou Guangming 
Published: May 2017

Abstract
Radiation-induced bone loss is a potential health concern for cancer patients undergoing radiotherapy. Enhanced bone resorption by osteoclasts and decreased bone formation by osteoblasts were thought to be the main reasons. In this study, we showed that both pre-differentiating and differentiating osteoclasts were relatively sensitive to X-rays compared with osteoblasts. X-rays decreased cell viability to a greater degree in RAW264.7 cells and in differentiating cells than than in osteoblastic MC3T3-E1 cells. X-rays at up to 8 Gy had little effects on osteoblast mineralization. In contrast, X-rays at 1 Gy induced enhanced osteoclastogenesis by enhanced cell fusion, but had no effects on bone resorption. A higher dose of X-rays at 8 Gy, however, had an inhibitory effect on bone resorption. In addition, actin ring formation was disrupted by 8 Gy of X-rays and reorganized into clusters. An increased activity of Caspase 3 was found after X-ray exposure. Actin disorganization and increased apoptosis may be the potential effects of X-rays at high doses, by inhibiting osteoclast differentiation. Taken together, our data indicate high radiosensitivity of osteoclasts. X-ray irradiation at relatively low doses can activate osteoclastogenesis, but not osteogenic differentiation. The radiosensitive osteoclasts are the potentially responsive cells for X-ray-induced bone loss.
Paratrigeminal, Paraclival, Precavernous, or All of the Above? A Circumferential Anatomical Study of the C3-C4 Transitional Segment of the Internal Carotid Artery
Authors: Marcati Eleonora , Andaluz Norberto , Froelich Sebastien C , Zimmer Lee A , Leach James L , Fernandez-Miranda Juan Carlos , Kurbanov Almaz , Keller Jeffrey T 
Published: May 2017

Abstract

BACKGROUND
Although the term paraclival carotid pervades recent skull base literature, no clear consensus exists regarding boundaries or anatomical segments.

OBJECTIVE
To reconcile various internal carotid artery (ICA) nomenclatures for transcranial and endoscopic-endonasal perspectives, we reexamined the transition between lacerum (C3) and cavernous (C4) segments using a C1-C7 segments schema. In this cadaveric study, we obtained a 360°-circumferential view integrating histological, microsurgical, endoscopic, and neuroradiological analyses of this C3-C4 region and identified a distinct transitional segment.

METHODS
In 13 adult, silicone-injected, formalin-fixed cadaveric heads (26 sides), transcranial-extradural-subtemporal and endoscopic-endonasal CT­guided dissections were performed. A quadrilateral area was noted medial to Meckel's cave between cranial nerve VI, anterolateral and posterolateral borders of the lateral-paratrigeminal aspect of the precavernous ICA, and posterior longitudinal ligament. Endoscopically, a medial-paraclival aspect was defined. Anatomical correlations were made with histological and neuroradiological slides.

RESULTS
We identified a distinct precavernous C3-C4 transitional segment. In 18 (69%) specimens, venous channels were absent at the quadrilateral area, on the paratrigeminal border of the precavernous ICA. A trigeminal membrane, seen consistently on the superior border of V2, defined the lateral aspect of the cavernous sinus floor. The medial aspect of the precavernous ICA corresponded with the paraclival ICA.

CONCLUSION
Our study revealing the juncture of 2 complementary borders of the ICA, endoscopic endonasal (paraclival) and transcranial (paratrigeminal), reconciles various nomenclature. A precavernous segment may clarify controversies about the paraclival ICA and support the concept of a “safe door” for lesions involving Meckel's cave, cavernous sinus, and petrous apex.
Utilization of Quantitative Susceptibility Mapping for Direct Targeting of the Subthalamic Nucleus During Deep Brain Stimulation Surgery
Authors: Rasouli Jonathan , Ramdhani Ritesh , Panov Fedor E , Dimov Alexey , Zhang Yan , Cho Catherine , Wang Yi , Kopell Brian Harris 
Published: May 2017

Abstract

BACKGROUND
Deep brain stimulation of the subthalamic nucleus (STN) has demonstrated efficacy in improving motor disability in Parkinson's disease. The recently developed quantitative susceptibility mapping (QSM) technique, which can accurately map iron deposits in deep brain nuclei, promises precise targeting of the STN.

OBJECTIVE
To demonstrate the use of QSM to target STN effectively by correlating with classical physiological-based targeting measures in a prospective study.

METHODS
The precision and accuracy of direct targeting with QSM was examined in a total of 25 Parkinson's disease patients between 2013 and 2015 at our institution. QSM was utilized as the primary magnetic resonance imaging (MRI) method to perform direct STN targeting on a stereotactic planning station utilizing computed tomography/MR fusion. Intraoperative microelectrode recordings (MER) were obtained to confirm appropriate trajectory through the sensorimotor STN.

RESULTS
Estimations of STN thickness between the MER and QSM methods appeared to be correlated. Mean STN thickness was 5.3 mm. Kinesthetic responsive cells were found in > 90% of electrode runs. The mean radial error (±SEM) was 0.54 ± 0.1 mm. Satisfactory clinical response as determined by Unified Parkinson's Disease Rating Scale (UPDRS III) was seen at 12 mo after surgery.

CONCLUSION
Direct targeting of the sensorimotor STN using QSM demonstrates MER correlation and can be safely used for deep brain stimulation lead placement with satisfactory clinical response. These results imply that targeting based on QSM signaling alone is sufficient to obtain reliable and reproducible outcomes in the absence of physiological recordings.
Graft Function and Intermediate-Term Outcomes of Kidney Transplants Improved in the Last Decade: Analysis of the United States Kidney Transplant Database
Authors: Keith Douglas Scott , Vranic Gayle , Nishio-Lucar Angie 
Published: May 2017

Background
Previous analyses of the United States transplant database regarding long-term outcomes in kidney transplantation have shown minimal improvement in the rate of long-term graft loss. This study sought to analyze intermediate-term outcomes and graft function at 6 months in kidney transplantation in adult living and deceased donor recipients in the last decade.

Methods
Survival analysis was performed based on the year of transplant between 6 months and 3 years’ posttransplant. The Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate (eGFR) was determined at 6 months.

Results
The unadjusted graft survival between 6 months and 3 years improved significantly in the latter half of the decade in both deceased and living donor kidney recipients. Cox analysis showed a 33% reduction in the rate of graft loss and that the improvement in graft survival was due to similar improvements in both death-censored graft and death with graft function survival. A 10% improvement in median eGFR occurred despite worsening donor demographics over time in both donor types. This improvement in eGFR and graft survival occurred in association with a consolidation of chronic discharge immunosuppression from a variety of combinations to over 85% of recipients receiving tacrolimus and mycophenolate derivative immunosuppression.

Conclusions
In the latter half of last decade graft survival improved in adult kidney transplant recipients. The improvement in graft survival occurred in temporal association with an improvement in median eGFR at 6 months and consolidation of discharge immunosuppression in most patients to tacrolimus and mycophenolate derivatives.
Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms
Authors: Zandawala Meet , Moghul Ismail , Yañez Guerra Luis Alfonso , Delroisse Jérôme , Abylkassimova Nikara , Hugall Andrew F. , O’Hara Timothy D. , Elphick Maurice R. 
Published: May 2017

AbstractNeuropeptides are a diverse class of intercellular signaling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signaling. Here detailed analysis of transcriptome sequence data from three brittle star species,Ophionotus victoriae, Amphiura filiformisandOphiopsila aranea, has enabled the first comprehensive identification of neuropeptide precursors in the class Ophiuroidea of the phylum Echinodermata. Representatives of over thirty bilaterian neuropeptide precursor families were identified, some of which occur as paralogs. Furthermore, homologs of endothelin/CCHamide, eclosion hormone, neuropeptide-F/Y and nucleobinin/nesfatin were discovered here in a deuterostome/echinoderm for the first time. The majority of ophiuroid neuropeptide precursors contain a single copy of a neuropeptide, but several precursors comprise multiple copies of identical or non-identical, but structurally-related, neuropeptides. Here we performed an unprecedented investigation of the evolution of neuropeptide copy-number over a period of ~270 million years by analysing sequence data from over fifty ophiuroid species, with reference to a robust phylogeny. Our analysis indicates that the composition of neuropeptide “cocktails” is functionally important, but with plasticity over long evolutionary time scales.
Mapping the malaria parasite drug-able genome usingin vitroevolution and chemogenomics
Authors: Cowell Annie N. , Istvan Eva S. , Lukens Amanda K. , Gomez-Lorenzo Maria G. , Vanaerschot Manu , Sakata-Kato Tomoyo , Flannery Erika L. , Magistrado Pamela , Abraham Matthew , LaMonte Gregory , Williams Roy M. , Franco Virginia , Linares Maria , Arriaga Ignacio , Bopp Selina , Corey Victoria C. , Gnädig Nina F. , Coburn-Flynn Olivia , Reimer Christin , Gupta Purva , Murithi James M. , Fuchs Olivia , Sasaki Erika , Kim Sang W. , Teng Christine , Wang Lawrence T. , Willis Paul , Siegel Dionicio , Tanaseichuk Olga , Zhong Yang , Zhou Yingyao , Ottilie Sabine , Gamo Francisco-Javier , Lee Marcus C.S. , Goldberg Daniel E. , Fidock David A. , Wirth Dyann F. , Winzeler Elizabeth A. 
Published: May 2017

AbstractChemogenetic characterization throughin vitroevolution combined with whole genome analysis is a powerful tool to discover novel antimalarial drug targets and identify drug resistance genes. Our comprehensive genome analysis of 262Plasmodium falciparumparasites treated with 37 diverse compounds reveals how the parasite evolves to evade the action of small molecule growth inhibitors. This detailed data set revealed 159 gene amplifications and 148 nonsynonymous changes in 83 genes which developed during resistance acquisition. Using a new algorithm, we show that gene amplifications contribute to 1/3 of drug resistance acquisition events. In addition to confirming known multidrug resistance mechanisms, we discovered novel multidrug resistance genes. Furthermore, we identified promising new drug target-inhibitor pairs to advance the malaria elimination campaign, including: thymidylate synthase and a benzoquinazolinone, farnesyltransferase and a pyrimidinedione, and a dipeptidylpeptidase and an arylurea. This deep exploration of theP. falciparumresistome and drug-able genome will guide future drug discovery and structural biology efforts, while also advancing our understanding of resistance mechanisms of the deadliest malaria parasite.One Sentence SummaryWhole genome sequencing reveals howPlasmodium falciparumevolves resistance to diverse compounds and identifies new antimalarial drug targets.