bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new TRIZ-based patent knowledge management system for construction technology innovation
Authors: Ding Zhikun , Jiang Shuanglong , Ng Fungfai , Zhu Menglian 
Published: June 2017

Purpose
The quantity of construction technology innovations in patent database grows at a high speed. More challenging technical problems require knowledge workers to make full use of the huge existing technology innovation knowledge base to propose new innovative solutions. Hence, it is critical to deliver the right knowledge to the right people at the right time. To improve innovation efficiency and effectiveness, this research explores the development of a new patent knowledge management system to satisfy the increasing demand of construction innovations.

Design/methodology/approach
TRIZ-based patent knowledge management system (TPKMS) development involves the integration of construction patent knowledge management, theory of inventive problem-solving (TRIZ) theory, database techniques and computer programing technology. The contradiction matrix in TRIZ theory serves as the patent knowledge extraction framework, while SQL Server 2000 database management system is employed to manage the extracted patent knowledge, TRIZ and user account information. Visual C++ 6.0 is adopted as the development tool.

Findings
The developed system to manage construction patent knowledge integrates TRIZ with the database design, enabling the system users to be more problem-focused, systematic and efficient. The system provides a heuristic environment to help improve the innovation effectiveness by motivating knowledge workers’ innovative thinking. Further development of the system is proposed in the context of the age of big data.

Originality/value
A new TRIZ-based patent knowledge management system for construction technology innovation was developed.
Investigation into the causes of delay in land acquisition for PPP projects in developing countries
Authors: Babatunde Solomon Olusola , Adeniyi Onaopepo , Awodele Oluwaseyi Alabi 
Published: June 2017

PurposeThe land is a critical resource for public-private partnerships (PPPs) in infrastructure development. However, acquisition of land for PPP infrastructure projects implementation increasingly becomes problematic in developing countries. Yet, effort at investigating the factors causing a delay in land acquisition for PPP infrastructure projects through an empirical method in developing countries received scant attention. Therefore, the purpose of this study is to identify and critically assess the factors predisposing PPP projects implementation to land acquisition delay in Nigeria using an empirical approach.Design/methodology/approachThe study adopted literature review and questionnaire survey. For instance, literature review was used to identify the factors causing delay in land acquisition for PPP projects in developing countries, which was used to design the questionnaire survey culminating in data analysis. To capture a broad perception, the questionnaires were administered to three different primary stakeholder groups comprised public sector authorities (i.e. ministries, department, agencies), concessionaires and lenders/banks involved in PPP projects implementation in Nigeria. Data collected were analysed using mean score, Kruskal–Wallis test and factor analysis.FindingsThe study revealed the mean score ranking of 22 identified factors causing a delay in land acquisition for PPP projects in Nigeria. The result of factor analysis grouped the 22 identified factors into 4 principal factors, namely, resettlement issues with political interference; non-availability of land with a higher cost of land transactions; weak planning institutions; and rehabilitation issues with extensive legal delays.Practical implicationsThese study findings have implications for both policymakers considering PPP projects and private investors seeking to finance a PPP project in developing countries. Also, the study findings would be useful for the governments in Nigeria and other developing countries to formulate clear policies framework that facilitates the smooth acquisition of land for PPP projects.Originality/valueThe study will be beneficial to the potential local and foreign private investors and governments by broadening their awareness on impediments in land acquisition for PPP projects in Nigeria and developing countries at large. These study findings are crucial, as not many empirical studies have been conducted in Nigeria and many other developing countries.
Relating CEO leadership behavior and organization culture in the Indian context
Authors: Frantz Terrill L. , Jain Ajay K. 
Published: June 2017

PurposeThe purpose of this paper is to examine the relationship between CEO leadership behavior and the culture of the organization within the context of Indian organizations.Design/methodology/approachTwo five-scale questionnaires were completed by senior executives (n=485) who have interaction with their CEO. The first instrument captured the executives’ perspective of their CEO’s leadership behavior along six dimensions (People Centric, Global Ambitions, Opportunity Sensing, Visionary, Exemplary, and Dependable). The second instrument captured the executives’ perspective of their organization’s culture along six dimensions (Results Focused, Talent Development, Employee Empowerment, Equity and Fairness, Open Communication, and Decentralization). These data were analyzed using factor analysis, correlation analysis, and least-squares regression.FindingsA correlation analysis indicates that a significant relationship exists between several aspects of CEO leadership behavior and characteristics of the organizational culture. Regression analysis indicated that the overall CEO leadership behavior prominently explains (R2=0.397) the organization’s culture. Notably, two CEO dimensions, People Centricity and Global Ambition, were found to have an exceptionally high degree of association with the culture of the organization.Research limitations/implicationsThere is consistency between findings from western academic leader-culture research and the same in the Indian work setting.Practical implicationsFindings of this study can serve as a guidepost for the selection of leaders in an organization.Originality/valueThere is a scarcity of leader-organization research involving national culture features; the Indian context is fundamental to this study and is called for by the growing presence of India-born leadership in western organizations.
Management of alopecia areata: Updates and algorithmic approach
Authors: Lee Solam , Lee Won‐Soo 
Published: June 2017

AbstractAlopecia areata is a chronic, recurrent and non‐scarring alopecia. The prognoses of patients are very diverse. The larger the area of hair loss, the poorer the treatment response and greater the probability of chronic disease progression. Numerous treatments have been introduced, but curative treatments have yet to be established. The long‐term efficacy of the current treatments is minimal, and the therapeutic response varies widely. Recent clinical trials have attempted to apply therapeutic metrics, such as the Severity of Alopecia Tool, and many have been designed as randomized controlled studies, enabling a more precise evaluation of existing treatments. There have been updates in practice, efficacy or indications of therapeutics that have been previously used. Moreover, the use of novel treatments such as biologics has recently been introduced. Commonly, the most important factor in determining the treatment modality for alopecia areata has been the extent of hair loss. However, if the disease activity is high and likely to progress, combination therapy with adjuvant modalities will be more desirable. This review will discuss the therapeutic effects of existing and newly‐introduced treatments based on their quantity, quality of evidence and expected complications. In addition, an algorithmic approach to management of alopecia areata is proposed according to clinical subtype, severity, onset and activity of the disease.
Pulsed food resources, but not forest cover, determine lifetime reproductive success in a forest‐dwelling rodent
Authors: Hoset Katrine S. , Villers Alexandre , Wistbacka Ralf , Selonen Vesa 
Published: June 2017

Abstract

The relative contributions of habitat and food availability on fitness may provide evidence for key habitat features needed to safeguard population persistence. However, defining habitat quality for a species can be a complex task, especially if knowledge on the relationship between individual performance and habitat quality is lacking.

Here, we determined the relative importance of the availability of suitable forest habitat, body mass and food from masting tree species on female lifetime reproductive success (LRS) of Siberian flying squirrels (Pteromys volans).

We calculated LRS of 500 female flying squirrels based on a 22‐year‐long longitudinal dataset of two populations from western Finland. We assessed with generalised additive models the potential effects of availability of suitable habitat and cumulative lifetime availability of food from masting tree species on female LRS, longevity and fecundity. On a reduced dataset, we evaluated the importance of female winter body mass and conducted a piecewise path analysis to determine how variables were connected.

According to generalised additive models female longevity, fecundity and LRS were mainly determined by variation in cumulative lifetime availability of food from masting alder and birch. Instead, habitat and body mass had a smaller role. The path analysis indicated that lifetime food availability had a direct effect on longevity and fecundity, and these had an equal effect on LRS at both study sites.

Our results on LRS show that the occurrence of tree masting events during a female flying squirrel's lifetime has a profoundly larger effect on LRS than the cover of suitable forest habitat. Furthermore, this study emphasises the importance of both fecundity and longevity, and the indirect effects of food availability via those components, as determinants of lifetime fitness in female flying squirrels.
Diffusion of Corporate Risk‐Management Characteristics: Perspectives of Chief Audit Executives through a Survey Approach
Authors: Christopher Joe , Sarens Gerrit 
Published: June 2017

AbstractThis study examines how corporate risk‐management characteristics in Australian public universities have diffused under an environment of conflicting management cultures. The findings reveal that corporate risk‐management characteristics have diffused in a pluralist form to satisfy stakeholders of different management approaches across its governance levels as opposed to a unilateral form aligned to the corporate approach. The accepted practice of this adapted version challenges the existing notion that the adoption of corporate control processes in the public sector is problematic, and provides insights into the emergence of a hybrid control process to address the needs of multiple stakeholders. These findings have policy implications for defining a new hybrid governance‐control paradigm for the public sector as an alternative to the corporate‐influenced control paradigm, and provide avenues for further research to confirm the phenomenon with other corporate control processes, public‐sector entities, and if so its impact on effective governance.
Dynamics and origin of cytokinins involved in plant manipulation by a leaf‐mining insect
Authors: Zhang Hui , Guiguet Antoine , Dubreuil Géraldine , Kisiala Anna , Andreas Peter , Emery R. J. Neil , Huguet Elisabeth , Body Mélanie , Giron David 
Published: June 2017

AbstractSeveral herbivorous insects and plant‐associated microorganisms control the phytohormonal balance, thus enabling them to successfully exploit the plant by inhibiting plant defenses and withdrawing plant resources for their own benefit. The leaf‐mining moth Phyllonorycter blancardella modifies the cytokinin (CK) profile of mined leaf‐tissues, and the insect symbiotic bacteria Wolbachia is involved in the plant manipulation to the benefit of the insect host. To gain a deeper understanding into the possible origin and dynamics of CKs, we conducted an extensive characterization of CKs in larvae and in infected apple leaves. Our results show the enhanced CK levels in mines, both on green and yellow leaves, allowing insects to control their nutritional supply under fluctuating environmental conditions. The spatial distribution of CKs within the mined leaves shows that hormone manipulation is strictly limited to the mine suggesting the absence of CK translocation from distant leaf areas toward the insect feeding site. Mass spectrometry analyses reveal that major CK types accumulating in mines and larvae are similar to what is observed for most gall‐inducers, suggesting that strategies underlying the plant manipulation may be shared between herbivorous insects with distinct life histories. Results further show that CKs are detected in the highest levels in larvae, reinforcing our hypothesis that CKs accumulating in the mines originate from the insect itself. Presence of bacteria‐specific methylthio‐CKs is consistent with previous results suggesting that insect bacterial symbionts contribute to the observed phenotype. Our study provides key findings toward the understanding of molecular mechanisms underlying this intricate plant–insect–microbe interaction.
The effect of CT scanners in the trauma room – an observational study
Authors: Wulffeld S. , Rasmussen L. S. , Højlund Bech B. , Steinmetz J. 
Published: June 2017

BackgroundA CT scanner incorporated in the trauma resuscitation bay may benefit trauma patients by fastening work‐up times; however, evidence in the area is still sparse. We assessed if time from admission to first CT scan was lower after incorporation of a CT scanner in the resuscitation bay.MethodsWe included trauma patients admitted in two 1‐year periods, before and after a major rebuilding of the trauma room. Beforehand, one CT scanner was located in an adjacent room. After the rebuilding, two mobile CT scanners were placed in the resuscitation bays, where a moving gantry was combined with a trauma resuscitation table. Subgroup analyses were performed on severely injured and patients with traumatic brain injury.ResultsWe included 784 patients before and 742 patients after the reconstruction. Case‐mix differed between study periods as there was a higher proportion of severe injuries, traumatic brain injury and penetrating trauma in the after period. We found a minor increase in time to CT in the after period (20 vs. 21 min, P = 0.008). In a multivariate regression analysis adjusted for differences in case‐mix and with time to CT as outcome, period was an insignificant explanatory variable [β (before vs. after): 0.96 min 95% CI: 0.9–1.02, P = 0.3]. In both subgroups, we found no significant difference in time to CT.ConclusionWe found no reduction in time to CT scan, when comparing a period with mobile CT scanners incorporated in the resuscitation bay to an earlier period with a CT scanner next to the trauma room.
Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption
Authors: Kallupi Marsida , Shen Qianwei , de Guglielmo Giordano , Yasuda Dennis , Journigan V. Blair , Zaveri Nurulain T. , Ciccocioppo Roberto 
Published: June 2017

AbstractBuprenorphine's clinical use is approved for the treatment of heroin addiction; however, evidence supporting its efficacy in cocaine abuse also exists. While for heroin it has been demonstrated that the effect of buprenorphine is mediated by its ability to activate μ‐opioid peptide receptor (MOP) receptors, the mechanism through which it attenuates cocaine intake remains elusive. We explored this mechanism using operant models where rodents were trained to chronically self‐administer cocaine for 2 hours daily. Buprenorphine (0.3, 1.0 and 3.0 mg/kg) given intraperitoneally 90 minutes before access to cocaine significantly and dose dependently reduced its intake. Pre‐treatment with naltrexone or with the selective nociceptin/orphanin FQ peptide (NOP) antagonist SB‐612111 did not prevent buprenorphine‐induced reduction of cocaine intake. However, when naltrexone and SB‐612111 were combined, the effect of buprenorphine on cocaine was completely prevented. To confirm that co‐activation of MOP and NOP receptors is the underlying mechanism through which buprenorphine reduces cocaine intake, three compounds, namely, AT‐034, AT‐201 and AT‐202, with a range of affinity and intrinsic activity profiles for MOP and NOP receptors, but weak ability for kappa‐opioid peptide receptor (KOP) transmission, were tested. Consistent with our hypothesis based on buprenorphine's effects, results demonstrated that AT‐034 and AT‐201, which co‐activate MOP and NOP receptors, reduced cocaine self‐administration like buprenorphine. AT‐202, which selectively stimulates NOP receptors, was not effective. Together, these data demonstrate that for buprenorphine, co‐activation of MOP and NOP receptors is essential to reduce cocaine consumption. These results open new vistas on the treatment of cocaine addiction by developing compounds with mixed MOP/NOP agonist properties.
Genetics‐based methods for agricultural insect pest management
Authors: Alphey Nina , Bonsall Michael B. 
Published: June 2017

AbstractThe sterile insect technique is an area‐wide pest control method that reduces agricultural pest populations by releasing mass‐reared sterile insects, which then compete for mates with wild insects. Contemporary genetics‐based technologies use insects that are homozygous for a repressible dominant lethal genetic construct rather than being sterilized by irradiation.
Engineered strains of agricultural pest species, including moths such as the diamondback moth Plutella xylostella and fruit flies such as the Mediterranean fruit fly Ceratitis capitata, have been developed with lethality that only operates on females.
Transgenic crops expressing insecticidal toxins are widely used; the economic benefits of these crops would be lost if toxin resistance spread through the pest population. The primary resistance management method is a high‐dose/refuge strategy, requiring toxin‐free crops as refuges near the insecticidal crops, as well as toxin doses sufficiently high to kill wild‐type insects and insects heterozygous for a resistance allele.
Mass‐release of toxin‐sensitive engineered males (carrying female‐lethal genes), as well as suppressing populations, could substantially delay or reverse the spread of resistance. These transgenic insect technologies could form an effective resistance management strategy.
We outline some policy considerations for taking genetic insect control systems through to field implementation.
Characteristics of corneal biomechanical responses detected by a non‐contact scheimpflug‐based tonometer in eyes with glaucoma
Authors: Jung Younhea , Park Hae‐Young L. , Yang Hee Jung , Park Chan Kee 
Published: June 2017

AbstractPurposeTo determine the corneal biomechanical properties in eyes with glaucoma using a non‐contact Scheimpflug‐based tonometer.MethodsCorneal biomechanical responses were examined using a non‐contact Scheimpflug‐based tonometer. The tonometer parameters of the normal control group (n = 75) were compared with those of the glaucoma group (n = 136), including an analysis of glaucoma subgroups categorized by visual field loss.ResultsAfter adjusting for potential confounding factors, including the intraocular pressure (IOP), central corneal thickness (CCT), age and axial length, the deformation amplitude was smaller in the glaucoma group (1.09 ± 0.02 mm) than in the normal control group (1.12 ± 0.02 mm; p value = 0.031). The deformation amplitude and the deflection amplitude of the severe glaucoma group (1.12 ± 0.02 mm and 0.92 ± 0.01 mm) were significantly greater than that of the early glaucoma group (1.07 ± 0.01 mm and 0.88 ± 0.11 mm, p = 0.006 and p = 0.031), whereas that of the moderate glaucoma group (1.09 ± 0.02 mm and 0.90 ± 0.02 mm) was greater than that of the early glaucoma group, but this difference was not statistically significant. The deformation amplitude showed a negative correlation with the CCT in the normal control group (r = −0.235), with a weaker negative relationship observed in the early glaucoma group (r = −0.099). However, in the moderate and severe glaucoma groups, the deformation amplitude showed a positive relationship with the CCT, showing an inverse relationship. The duration and number of antiglaucomatous eyedrops used had negative correlations with the CCT in eyes with moderate and severe glaucoma.ConclusionOverall, the glaucoma group showed significantly less deformable corneas than did the normal controls, even after adjusting for the IOP, CCT, age and axial length. However, there were also differences according to the severity of glaucoma, where the corneal deformation amplitude was greater in the severe glaucoma group compared to the early glaucoma group. The combined effects of stiffening due to glaucoma and increased viscoelastic properties caused by the chronic use of antiglaucomatous eyedrops may have resulted in the present findings.
Bilateral diffuse uveal melanocytic proliferation: Case report and literature review
Authors: Klemp Kristian , Kiilgaard Jens Folke , Heegaard Steffen , Nørgaard Tove , Andersen Mette Klarskov , Prause Jan Ulrik 
Published: June 2017

AbstractBilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.
C‐Reactive protein and progression of vision loss in retinitis pigmentosa
Authors: Murakami Yusuke , Ikeda Yasuhiro , Nakatake Shunji , Fujiwara Kohta , Tachibana Takashi , Yoshida Noriko , Notomi Shoji , Hisatomi Toshio , Yoshida Shigeo , Ishibashi Tatsuro , Sonoda Koh‐Hei 
Published: June 2017

AbstractPurposeChronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit‐lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship between serum high‐sensitivity C‐reactive protein (hs‐CRP) and visual parameters in RP.MethodsWe studied 58 consecutive typical patients with RP <40 years old and 29 age‐ and gender‐matched controls. High‐sensitivity C‐reactive protein (hs‐CRP) was detected by immunoturbidimetry. The relationships between hs‐CRP and visual parameters including best‐corrected visual acuity (BCVA), mean deviation (MD) of static perimetry tests (Humphrey Field Analyzer, the central 10‐2 programme) and VA changes over the prior 5 years and MD changes over the prior 3 years were analysed in the patients with RP.ResultsThe serum hs‐CRP levels of the patients with RP were significantly higher than those of the controls (0.06 ± 0.08 versus 0.03 ± 0.04 mg/dl, p = 0.0119). In the patients with RP, there was no correlation of hs‐CRP with cross‐sectionally assessed VA or MD, but the baseline hs‐CRP was significantly correlated with the MD deterioration (r = −0.4073, p = 0.0314).ConclusionThe average serum hs‐CRP was significantly increased in the patients with RP, and higher hs‐CRP was associated with faster deterioration of central visual function. These results suggest that the systemic inflammatory profile is altered and may be associated with disease progression in RP.