bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACL status in arthroplasty patients, why not to preserve?
Authors: Abdelbadie Ahmed , Toreih Ahmed Ali , Radwan Mohamed Ahmed 
Published: January 2018

Introduction: Only 70–85% of patients that had total knee arthroplasty (TKA) are satisfied with their knees. The need for a near to normal knee kinematics is crucial and maybe the solution to their needs. Addressing the cruciate ligaments during surgery along with the extent of arthrosis may give a solution to this problem.

Material and methods: One hundred consecutive patients in whom a total knee arthroplasty was indicated and performed were prospectively documented. During the knee replacement surgery, the condition of the anterior and posterior cruciate ligaments and the degree of osteoarthritis (OA) in the medial and lateral compartments as well as in the patello-femoral joint were documented using the Outerbridge classification. The patients’ average age was 72.3 years, with the majority being female. In all patients, a total bi-compartmental knee replacement was indicated.

Results: Our results showed that in 78% of all patients the anterior, and in 98% the posterior cruciate ligament was still intact. Seventy-one percent of cases suffered from grade 4 medial osteoarthritis, 19% from grade 3 and 10% from grade 2. Thirty-six of patients suffered from grade 4 lateral osteoarthritis, 36% from grade 3, 24% from grade 2 and 4% from grade 1. Grade 4 patello-femoral osteoarthritis was present in 32% of all patients, grade 3 in 60% and grade 2 in 8% of all patients.

Discussion: The goal of arthroplasty is to approximate the function of a normal knee. The retention of the anterior cruciate ligament (ACL) allows for better knee, kinematics, improved proprioception, increased flexion and an overall improvement in knee function. The decreased constraint that is possible with retention of both cruciates may decrease implant stresses and improve the implant survivorship. The distribution of OA shows that the medial and patello-femoral compartments of the joint are primarily affected. This could also allow for a more conservative and patient-tailored prosthetic design.
One-Stage Laparoscopic Surgery for Pulmonary Sequestration and Hiatal Hernia in a 2-Year-Old Girl
Authors: Miyagi Hisayuki , Honda Shohei , Hamada Hiromi , Minato Masashi , Ara Momoko , Taketomi Akinobu 
Published: January 2018

AbstractWe herein report a case of one-stage laparoscopic surgery for extralobar pulmonary sequestration (EPS) and hiatal hernia. Our patient was a 2-year-old girl who was diagnosed as a mediastinal mass lesion. Postnatal computed tomography revealed that the mediastinal mass was an EPS. Two weeks after birth, the patient developed gastroesophageal reflux (GER), and esophagography showed a hiatal hernia. At 2 years of age, she underwent one-stage laparoscopic Nissen's fundoplication for GER with resection of the EPS in the posterior mediastinum. The sequestrated lung was grasped via the esophageal hiatus; three aberrant blood vessels were dissected to allow removal of the sequestration through the umbilical port site. The esophageal hiatus was repaired and Nissen's fundoplication was performed laparoscopically. The patient's postoperative course was uneventful, with no recurrence of GER symptoms for 1 year. We conclude that one-stage laparoscopic surgery is useful for patients with EPS and hiatal hernia.
Absceso subpectoral como diagnóstico diferencial de hombro doloroso – reporte de un caso
Authors: Palma Concha José , Gómez Meier Andrés , Herrera Otto Enrique , Besser Mahuzier Juan , Ayres Henriquez George 
Published: January 2018

ResumenLos síndromes dolorosos del hombro son relativamente comunes en la práctica clínica. Habitualmente son causados por un número limitado de patologías. Dentro de los diagnósticos diferenciales, el pinzamiento subacromial, las lesiones aisladas del manguito rotador, capsulitis adhesiva, tendinitis cálcica, patología degenerativa de las articulaciones glenohumeral y acromioclavicular, y la inestabilidad crónica del hombro, son causas comunes. Causas infrecuentes son la rotura del tendón del bíceps, neuralgias, patología infecciosa articular y tumores del hombro. Un absceso subpectoral sin sintomatología infecciosa clara es una causa extremadamente rara de hombro doloroso en el adulto. Presentamos el caso de un paciente de 60 años, que inicia con un cuadro de hombro doloroso cuya causa se identifica como un absceso subpectoral por staphylococcus aureus que se maneja con drenaje quirúrgico y tratamiento antibiótico endovenoso con buenos resultados.
Zerebrale Sinus/-Venenthrombose durch zervikale Lymphadenopathie mit Jugularvenenkompression bei akuter EBV-Infektion
Authors: Willems Laurent , Wallenwein Stephanie , Lauer Arne , Schäfer Jan , Wagner Marlies , Reinhuber Franziska , Strzelczyk Adam , Steinmetz Helmuth , Pfeilschifter Waltraud 
Published: January 2018

ZusammenfassungWir berichten über eine 23-jährige Patientin, die sich in unserer Klinik aufgrund einer akut aufgetretenen, schweren Wesensveränderung sowie seit mehreren Wochen bestehender Cephalgien und fieberhaftem Infekt vorstellte. Als Ursache zeigte sich eine äußere und innere zerebrale Sinus/-Venenthrombose, welche auf eine venöse Drainagebehinderung bei Kompression der V. jugularis interna links durch eine ausgeprägte zervikale Lymphadenopathie bei Pfeifferschem Drüsenfieber (Epstein-Barr-Virus-Infektion) zurückzuführen war. Unter Therapie mit niedermolekularem Heparin bildete sich die Symptomatik weitgehend zurück.
Myasthenic Syndromes – Impact of Rehabilitation and Sports
Authors: Henze Thomas 
Published: January 2018

SummaryPatients suffering from disorders of neuromuscular transmission are only rarely admitted to rehabilitation facilities. However, patients suffering from severe muscular weakness of arms or legs, dysphagia, dysarthria, or respiratory insufficiency, especially after myasthenic crisis, will benefit from rehabilitation. Its goal is maximal reduction of existing disabilities that will enable participation in social life. Besides extensive knowledge of the clinical course and potential complications of myasthenic syndromes, a comprehensive rehabilitation concept is an important prerequisite for successful rehabilitation that includes individual and multimodal physical training as well as coping with the disease, public health medical aspects, education, and assistive devices.
Sakrileg – oder die Reise zu den Anfängen der Wissenschaft
Authors: Winter Norbert 
Published: January 2018

ZusammenfassungDie moderne Physik stellte die Physiker vor Rätsel, die nicht mit dem wissenschaftlichen Grundverständnis jener Zeit lösbar waren. Dies zwang Wolfgang Pauli dazu, die Hintergründe des naturwissenschaftlichen Denkens genauer zu hinterfragen. Dabei wurde deutlich, dass nicht allein rationale Erkenntnisse die treibende Kraft der Entwicklung der Naturwissenschaft waren, sondern dass diese bereits in ihrem Keim intuitive und spirituelle Dimensionen aufweist. Und somit genau das in sich trägt, was sie negiert.
Über den hohen Stellenwert der im TTB systematisierten, klinischen Erfahrungen Bönninghausens für die Alltagspraxis
Authors: Zwemke Hans 
Published: January 2018

ZusammenfassungDer Artikel demonstriert die hohe Effektivität der mittels der Polaritätsanalyse auf der Grundlage des TTB aufgefundenen Arzneien bei der erfolgreichen Behandlung von 3 Fällen mit Infektionskrankheiten aus dem HNO-Bereich, und zwar trotz unklarer Auskunft der primären Materia medica und widersprüchlichen bis teilweise sogar irreführenden Informationen aus anderen Quellen. Er zeigt ferner die prinzipielle Bedeutung von Bönninghausens klinisch-homöopathischen Erfahrungen mit ihren daraus abgeleiteten Schlussfolgerungen, wie sie sich in den Modalitäten des TTB niederschlagen, als geradezu revolutionären und zukunftsweisenden Fortschritt in der Repertoriumskonzeption, deren Weiterentwicklung zur Erhöhung der Verschreibungssicherheit uns überlassen bleibt.
Regelungen zum Personalbedarf für Ärzte in neurologischen Kliniken – ein Plädoyer
Authors: Grau Armin , Maschke Matthias , Baier Bernhard , Wöhrle Johannes , Gröschel Klaus , Jobst Ulrich , Pfeiffer Uwe , Fiedler Manfred 
Published: January 2018

ZusammenfassungVerkürzte Liegezeiten, wachsender administrativer Aufwand, eine zunehmende Komplexität in Diagnostik und Therapie und der wirtschaftliche Druck gehen mit einer Zunahme der Arbeitsdichte für Ärzte in neurologischen Kliniken einher. Eine zu hohe Arbeitsdichte kann die Behandlungsqualität beeinträchtigen und die Ausbildung von Assistenzärzten gefährden. In der Pflege, in psychiatrischen Kliniken und im Bereich der neurologischen Rehabilitation gibt es aktuell Ansätze, Mindestpersonalstandards einzuführen. Vor diesem Hintergrund plädieren die Autoren für:– die Einführung von Personaluntergrenzen für Ärzte in neurologischen Kliniken, aber auch für andere Berufsgruppen und andere medizinische Fächer– die Entwicklung eines Personalbemessungsinstruments, mit dessen Hilfe für jede Klinik ein angemessener Personalschlüssel festgelegt werden kann– eine Verbindlichkeit der Personalstandards einschließlich einer kompletten Gegenfinanzierung – realistische Übergangsfristen angesichts des aktuellen Ärztemangels
Preferences for moral vs. immoral traits in others are conditional
Authors: Melnikoff David E. , Bailey April H. 
Published: January 2018

SignificanceIt is commonly argued that humans have a dominant preference for morality traits vs. immorality traits in others—that is, irrespective of the surrounding context, morality fosters liking, and immorality fosters disliking. The results of four experiments oppose this view by showing that situational goals can eliminate and even reverse the preference for morality vs. immorality in others. These findings suggest that our preference for morality vs. immorality is conditional on the demands of our current goals and cannot be attributed solely to innate, “hardwired” links or personal learning experiences. They also suggest that immoral people sometimes win public adoration, and the power that comes with it, not in spite of but precisely because of their immorality.
Phenotypic selection as the biological mode of epigenetic conversion and reversion in cell transformation
Authors: Rubin Harry , Rubin Andrew L. 
Published: January 2018

SignificanceSingle exposure of a certain mouse cell line to carcinogens causes delayed neoplastic transformation of most, if not all its cells. In the absence of carcinogens, the extended maintenance at high density of another cell line or of cells recently explanted from mice leads to increased saturation density, neoplastically transformed foci in culture, and tumor formation in mice. These properties are reversed to normal by frequent passages at low cell density in high serum concentrations. Such population-wide dynamics are incompatible with somatic mutation but are characteristic of epigenetic behavior. They represent phenotypic selection of cells from a normal population which progresses either to cancer or to the reversion of transformed cells to pretreatment phenotype, depending on differing microenvironments.
When multi-functional landscape meets Critical Zone science: advancing multi-disciplinary research for sustainable human well-being
Authors: Luo Ying , Lü Yihe , Fu Bojie , Harris Paul , Wu Lianhai , Comber Alexis 
Published: January 2018

Abstract
Environmental degradation has become one of the major obstacles to sustainable development and human well-being internationally. Scientific efforts are being made to understand the mechanism of environmental degradation and sustainability. Critical Zone (CZ) science and research on the multi-functional landscape are emerging fields in Earth science that can contribute to such scientific efforts. This paper reviews the progress, similarities and current status of these two scientific research fields, and identifies a number of opportunities for their synergistic integration through functional and multi-functional approaches, process-based monitoring, mechanistic analyses and dynamic modeling, global long-term and networked monitoring and systematic modeling supported by scaling and deep coupling. These approaches proposed in this paper have the potential to support sustainable human well-being by strengthening a functional orientation that consolidates multi-functional landscape research and CZ science. This is a key challenge for sustainable development and human well-being in the twenty-first century.
Posttraumatic Stress Disorder Symptoms and Suicide Risk in Male Firefighters
Authors: Boffa Joseph W. , Stanley Ian H. , Smith Lia J. , Mathes Brittany M. , Tran Jana K. , Buser Sam J. , Schmidt Norman B. , Vujanovic Anka A. 
Published: January 2018

Abstract
Posttraumatic stress disorder (PTSD) symptoms are positively related to suicide risk among firefighters. One mechanism that may account for this relationship is anxiety sensitivity (AS) cognitive concerns—the fear that cognitive symptoms of anxiety will have catastrophic consequences. We sought to replicate the mediating effect of AS cognitive concerns on the relationship between PTSD symptoms and suicide risk among 214 trauma-exposed male firefighters with non-zero suicide risk. Bootstrap mediation analyses tested AS cognitive concerns as a statistical mediator of PTSD symptoms (total and symptoms clusters scores) and suicide risk, controlling for depression symptoms and relevant demographic variables. AS cognitive concerns statistically mediated the relationship between PTSD symptoms (total score, as well as intrusion, avoidance, and arousal-reactivity symptoms clusters) and suicide risk; however, the reverse was also true. AS cognitive concerns may confer risk for suicide among trauma-exposed firefighters. Firefighters may benefit from AS-specific interventions, which are shown to reduce PTSD symptoms and suicidality.
Is the Garden Gun (Flobert 9 mm) Capable of Inducing Fatal Injury?
Authors: Pavlidis Pavlos , Karakasi Maria-Valeria , Kouroupi Maria , Theodoropoulou Efthimia , Birbilis Theodossios A. 
Published: January 2018

Abstract
This article presents both a fatal suicide incident by Flobert 9 mm-type smoothbore weapon with a single-shot projectile and a nonfatal case of a suicide attempt by the same weapon type with a dispersion cartridge from the authors' forensic record. A retrospective study was conducted examining 84 cases involving cases of headshots inflicted by all kinds of weapons deriving from the broader region of Eastern Macedonia and Thrace (Northern Greece) between 2000 and 2015, among which only 1 involved lethal wounding by a Flobert 9 mm (1.19%). Only a single case report of a fatality with such a weapon has been described throughout international literature. A comparative study also follows between the 3 incidents. The authors argue that a prerequisite for the lethal outcome of the shooting is the absolute contact of the weapon to the head as well as its placement at an anatomical point where the bone resistance is relatively lower, so that the intracranial entry of the projectile is possible. It is also more harmful if the cartridge contains a single-shot projectile rather than multiple projectiles of smaller diameter.
Days Gained: A Simulation-Based, Response Metric in the Assessment of Glioblastoma
Authors: De Leon Gustavo , Singleton Kyle W. , Swanson Kristin R. 
Published: January 2018

AbstractWe show the application of a minimally based, patient-specific mathematical model in the evaluation of glioblastoma response to therapy. Days Gained uses computational models of glioblastoma growth dynamics derived from clinically acquired magnetic resonance imaging (MRI) to compare the post-treatment tumor lesion to the expected untreated tumor lesion at the same time point. It accounts for the inter-patient variability in growth dynamics and response to therapy. This allows for the accurate assessment of therapeutic response and provides insight into overall survival as it relates to treatment response.
Abnormal spontaneous neural activity of auditory cortex and auditory pathway in tinnitus: a resting-state fMRI study
Authors: Cai Wei-Wei , Liang Jian-Gang , Li Zhi-Hui , Huang Yu-lin , Wang Li , Zhang Tao 
Published: January 2018

AbstractThis resting-state functional magnetic resonance imaging (rs-fMRI) study in tinnitus patients was conducted to observe the spontaneous neural activity of the central auditory system using a derived index, mean amplitude of low-frequency fluctuation (mALFF). Tinnitus subjects with right-ear hearing impairment (THL) and without hearing loss (TNH) and two age-, sex-, and education-matched control groups (NC1 and NC2) were recruited for rs-fMRI. mALFF maps of the tinnitus and matched NC groups were plotted in the central auditory system, including the primary auditory cortex (PAC), higher auditory cortex (HAC), and hubs of the central auditory pathway. mALFF values of the activity clusters in the central auditory system of THL and TNH patients were extracted and correlated with each clinical characteristic. Significantly increased mALFF clusters were found in bilateral PAC and HAC of THL-NC1 maps and in the left inferior colliculus and right HAC of TNH-NC2 maps. Thus, subgroups of tinnitus with and without hearing impairment might exhibit different homeostatic plasticity in the central auditory system. mALFF values of aberrant active clusters in the central auditory system are partly associated with specific clinical tinnitus characteristics.
Novel Integrative Modeling of Molecules and Morphology across Evolutionary Timescales
Authors: Ogilvie Huw A. , Mendes Fábio K. , Vaughan Timothy G. , Matzke Nicholas J. , Stadler Tanja , Welch David , Drummond Alexei J. 
Published: January 2018

AbstractEvolutionary models account for either population- or species-level processes, but usually not both. We introduce a new model, the FBD-MSC, which makes it possible for the first time to integrate both the genealogical and fossilization phenomena, by means of the multispecies coalescent (MSC) and the fossilized birth-death (FBD) processes. Using this model, we reconstruct the phylogeny representing all extant and many fossil Caninae, recovering both the relative and absolute time of speciation events. We quantify known inaccuracy issues with divergence time estimates using the popular strategy of concatenating molecular alignments, and show that the FBD-MSC solves them. Our new integrative method and empirical results advance the paradigm and practice of probabilistic total evidence analyses in evolutionary biology.
Rapid Identification and Validation of Novel Rheumatoid Arthritis Drug Treatments using an Integrative Bioinformatics Platform
Authors: Daugherty Aaron C. , Farrington Carl , Hakim Isaac , Mujahid Sana , Noblin Elizabeth S. , Radin Andrew M. , Chua Mei-Sze , Rabe Mark , Fernald Guy , Ford Daniel , Sirota Marina , Schaevitz Laura , Radin Andrew A. 
Published: January 2018

AbstractThe majority of drugs currently used to treat rheumatoid arthritis (RA) act on a small number of immunomodulatory targets. We applied an integrative biomedical-informatics-based approach andin vivotesting to identify new drug candidates and potential therapeutic targets that could form the basis for future drug development in RA. A computational model of RA was constructed by integrating patient gene expression data, molecular interactions, and clinical drug-disease associations. Drug candidates were scored based on their predicted efficacy across these data types. Ten high-scoring candidates were subsequently screened in a collagen-induced arthritis model of RA. Treatment with exenatide, olopatadine, and TXR-112 significantly improved multiple preclinical endpoints, including animal mobility which was measured using a novel digital platform. These three drug candidates do not act on common RA therapeutic targets; however, links between known candidate pharmacology and pathological processes involved in RA suggest hypothetical mechanisms contributing to the observed efficacy.
Real time genetic compensation operationally defines the dynamic demands of feedback control
Authors: Harrigan Patrick , Madhani Hiten D. , El-Samad Hana 
Published: January 2018

SUMMARYBiological signaling networks use feedback control to dynamically adjust their operation in real time. Traditional static genetic methods such as gene knockouts or rescue experiments often can identify the existence of feedback interactions, yet are unable to determine what feedback dynamics are required. Here, we implement a new strategy, closed loop optogenetic compensation (CLOC), to address this problem. Using a custom-built hardware and software infrastructure, CLOC monitors in real time the output of a pathway deleted for a feedback regulator. A minimal model uses these measurements to calculate and deliver—on the fly—an optogenetically-enabled transcriptional input designed to compensate for the effects of the feedback deletion. Application of CLOC to the yeast pheromone response pathway revealed surprisingly distinct dynamic requirements for three well-studied feedback regulators. CLOC, a marriage of control theory and traditional genetics, presents a broadly applicable methodology for defining the dynamic function of biological feedback regulators.
“Hemicellulose Degradation and Utilization by a SyntheticSaccharomyces cerevisiaeConsortium”
Authors: Tabañag Ian Dominic F. , Tsai Shen-Long 
Published: January 2018

AbstractSinceSaccharomyces cerevisiaedoes not inherently possess the capability to utilize pentose sugars released from hemicellulose degradation, the degradation and utilization of hemicellulose poses a conundrum to bioethanol production by consolidated bioprocessing (CBP) usingS. cerevisiae. In this study,S. cerevisiaewas exploited for its ability to degrade xylan, one of the major polysaccharide chains present in hemicellulose. Different hemicellulases fromTrichoderma reesei, namely: endoxylanase (Xyn2),β-xylosidase (Bxl1), acetylxylan esterase (Axe1),α-D-glucuronidase (Glr1) andα-L-arabinofuranosidase (Abf1), were heterologously secreted byS. cerevisiae. A mixture experimental design was adapted to statistically describe the synergistic interactions between the hemicellulases and to determine the optimum formulations for the hydrolysis of xylan substrates. The hydrolytic activities of the hemicellulase mixtures were then improved by displaying the hemicellulases on the yeast surface to serve as whole-cell biocatalysts. The engineered yeast strains displaying hemicellulases were further engineered with xylose-utilization genes to enable abilities of utilizing xylose as a sole carbon source. The resulting consortia were then able to grow and produce ethanol from different xylan substrates.