bluuebunny/crossref_metadata_2025_split huggingface dataset:
The specificity of the neural response to speech at birth
Authors: May Lillian , Gervain Judit , Carreiras Manuel , Werker Janet F. 
Published: May 2017

AbstractIn this work we ask whether at birth, the human brain responds uniquely to speech, or if similar activation also occurs to a non‐speech surrogate ‘language’. We compare neural activation in newborn infants to the language heard in utero (English), to an unfamiliar language (Spanish), and to a whistled surrogate language (Silbo Gomero) that, while used by humans to communicate, is not speech. Anterior temporal areas of the neonate cortex are activated in response to both familiar and unfamiliar spoken language, but these classic language areas are not activated to the whistled surrogate form. These results suggest that at the time human infants emerge from the womb, the neural preparation for language is specialized to speech.
Comparing student and staff perceptions of the “Educational Climate” in Spanish Dental Schools using the Dundee Ready Education Environment Measure
Authors: Tomás I. , Aneiros A. , Casares‐de‐Cal M. A. , Quintas V. , Prada‐López I. , Balsa‐Castro C. , Ceballos L. , Gómez‐Moreno G. , Llena C. , López‐Jornet P. , Machuca M. C. , Palés J. 
Published: May 2017

AbstractObjectiveTo compare the perceptions of students and teachers of the “Educational Climate” (EC) in Spanish public dental schools.MethodsA group of 1064 students and 354 teachers from six Spanish public dental schools responded to the DREEM questionnaire. This has 50 items grouped into five subscales: perception of learning (Learning); perception of teachers (Teachers); academic self‐perceptions (Academic); perception of the atmosphere in the faculty (Atmosphere); and social self‐perceptions (Social). The DREEM scale provides results for each item, each subscale and the overall EC.ResultsThe EC scores were 123.2 (61.6%) for the students and 134.1 (67.0%) for the teachers (P<.001). The scores of the students and teachers for the subscales were, respectively: 27.9 (58.1%) and 30.2 (63.0 %) for Learning (P<.001); 26.8 (60.9%) and 32.6 (74.1%) for Teachers (P<.001); 20.7 (64.7%) and 20.5 (64.0%) for Academic (P=.333); 29.9 (62.3%) and 33.7 (70.3%) for Atmosphere (P<.001); and 17.9 (64.0%) and 16.9 (60.5%) for Social (P<.001). The students identified six problematic items (12.0 %) compared to only two (4.0 %) highlighted by the teachers.ConclusionThe students and teachers considered the EC to be “more positive than negative” in Spanish public dental schools; and the different subscales to be “positive and acceptable.” The teachers did, however, evaluate the EC, and specifically the learning‐teaching process, more positively than their students, identifying fewer problematic educational aspects. Both groups agreed on the need to: improve support systems for students who suffer from stress and reduce teaching based on “factual learning.”
Implementation of a digital preparation validation tool in dental skills laboratory training
Authors: Kozarovska A. , Larsson C. 
Published: May 2017

AbstractAimTo describe the implementation of a digital tool for preparation validation and evaluate it as an aid in students’ self‐assessment.MethodsStudents at the final semester of skills laboratory training were asked to use a digital preparation validation tool (PVT) when performing two different tasks; preparation of crowns for teeth 11 and 21. The students were divided into two groups. Group A self‐assessed and scanned all three attempts at 21 (“prep‐and‐scan”). Group B self‐assessed all attempts chose the best one and scanned it (“best‐of‐three”). The situation was reversed for 11. The students assessed five parameters of the preparation and marked them as approved (A) or failed (F). These marks were compared with the information from the PVT. The students also completed a questionnaire. Each question was rated from 1 to 5. Teachers’ opinions were collected at staff meetings throughout the project.ResultsMost students in the “prep‐and‐scan” groups showed an increase in agreement between their self‐assessment and the information from the PVT, whereas students in the “best‐of‐three” groups showed lower levels of agreement. All students rated the PVT positively. Most strongly agreed that the tool was helpful in developing skills (mean 4.15), easy to use (mean 4.23) and that it added benefits in comparison to existing assessment tools (mean 4.05). They did not however, fully agree that the tool is time efficient (mean 2.55), and they did not consider it a substitute for verbal teacher feedback. Teachers’ feedback suggested advantages of the tool in the form of ease of use, visual aid and increasing interest and motivation during skills laboratory training however, they did not notice a reduction in need of verbal feedback.ConclusionsWithin the limitations of the study, our conclusion is that a digital PVT may be a valuable adjunct to other assessment tools in skills laboratory training.
Adverse event management in patients with relapsed and refractory multiple myeloma taking pomalidomide plus low‐dose dexamethasone: A pooled analysis
Authors: Moreau Philippe , Dimopoulos Meletios A. , Richardson Paul G. , Siegel David S. , Cavo Michele , Corradini Paolo , Weisel Katja , Delforge Michel , O'Gorman Peter , Song Kevin , Chen Christine , Bahlis Nizar , Oriol Albert , Hansson Markus , Kaiser Martin , Anttila Pekka , Raymakers Reinier , Joao Cristina , Cook Gordon , Sternas Lars , Biyukov Tsvetan , Slaughter Ana , Hong Kevin , Herring Jennifer , Yu Xin , Zaki Mohamed , San‐Miguel Jesus 
Published: May 2017

AbstractObjectivesHeavily pretreated patients with relapsed and refractory multiple myeloma are susceptible to treatment‐related adverse events (AEs). Managing AEs are important to ensure patients continue therapy long enough to receive the best clinical benefit. Data from the MM‐002, MM‐003, and MM‐010 trials were pooled to further characterize the safety profile of pomalidomide plus low‐dose dexamethasone and AE management.MethodsThis analysis included 1088 patients who received ≥ 2 prior therapies, including lenalidomide and bortezomib, and progressed ≤ 60 days of last therapy. Patients received 28‐day cycles of pomalidomide 4 mg/day on days 1‐21 and low‐dose dexamethasone 40 mg (20 mg if aged > 75 years) weekly until disease progression or unacceptable toxicity. Thromboprophylaxis was required.ResultsThe most common grade 3/4 AEs were neutropenia (56.2%), anemia (32.3%), and thrombocytopenia (25.8%), which occurred within the first few cycles of treatment. Grade 3/4 infections occurred in 33.7% patients, of whom 13.9% had pneumonia, and 40.3% had neutropenia. Pomalidomide dose reductions or interruptions were reported in 24.2% and 66.0% of patients, respectively. AEs were managed by dose modifications and/or supportive care.ConclusionsPomalidomide plus low‐dose dexamethasone showed an acceptable safety profile, and AEs were well managed according to study protocols and established guidelines.
Neural correlates of visuomotor adjustments during scaling of human finger movements
Authors: Brand Johannes , Michels Lars , Bakker Romy , Hepp‐Reymond Marie‐Claude , Kiper Daniel , Morari Manfred , Eng Kynan 
Published: May 2017

AbstractVisually guided finger movements include online feedback of current effector position to guide target approach. This visual feedback may be scaled or otherwise distorted by unpredictable perturbations. Although adjustments to visual feedback scaling have been studied before, the underlying brain activation differences between upscaling (visual feedback larger than real movement) and downscaling (feedback smaller than real movement) are currently unknown. Brain activation differences between upscaling and downscaling might be expected because within‐trial adjustments during upscaling require corrective backwards accelerations, whereas correcting for downscaling requires forward accelerations. In this behavioural and fMRI study we investigated adjustments during up‐ and downscaling in a target‐directed finger flexion–extension task with real‐time visual feedback. We found that subjects made longer and more complete within‐trial corrections for downscaling perturbations than for upscaling perturbations. The finger task activated primary motor (M1) and somatosensory (S1) areas, premotor and parietal regions, basal ganglia, and cerebellum. General scaling effects were seen in the right pre‐supplementary motor area, dorsal anterior cingulate cortex, inferior parietal lobule, and dorsolateral prefrontal cortex. Stronger activations for down‐ than for upscaling were observed in M1, supplementary motor area (SMA), S1 and anterior cingulate cortex. We argue that these activation differences may reflect differing online correction for upscaling vs. downscaling during finger flexion‐extension.
Role of anticholinergic burden in primary care patients with first cognitive complaints
Authors: Grande G. , Tramacere I. , Vetrano D. L. , Clerici F. , Pomati S. , Mariani C. , Filippini G. ,   the REMIND Study Group (Rete Milanese Integrata per le Demenze)
Published: May 2017

Background and purposeDrugs with anticholinergic properties might have a negative impact on cognition, but findings are still conflicting. The association was evaluated between anticholinergic drugs and cognitive performance in primary care patients with first cognitive complaints.MethodsFrom April 2013 to March 2014, 353 general practitioners administered the Mini‐Mental State Examination (MMSE) to patients presenting with first cognitive complaints. Drug history was collected and the anticholinergic cognitive burden (ACB) was scored and categorized as ACB 0, ACB 1 and ACB 2+. A mixed effect linear regression model was used to assess the association between ACB and MMSE score.ResultsOf 4249 subjects entering the study (mean age 77 ± 8.2 years, 66.4% women and mean years of schooling 8.9 ± 4.5), 25.8% received at least one drug with anticholinergic action. According to multivariate analysis, and after adjustment for several confounders, subjects with ACB 2+ had a statistically significant lower MMSE score compared with those with ACB 0 (β −0.63; 95% confidence interval −1.19; −0.07). Subjects with ACB 1 had a non‐statistically significant lower MMSE score than those with ACB 0 (β −0.11; 95% confidence interval −0.37; 0.15).ConclusionsAnticholinergic medication might affect cognitive function in people with first cognitive complaints. Alternatives should be taken into account when possible, balancing the benefits and harms of these medications.
Automatic detection of paroxysmal atrial fibrillation in patients with ischaemic stroke: better than routine diagnostic workup?
Authors: Uphaus T. , Grings A. , Gröschel S. , Müller A. , Weber‐Krüger M. , Wachter R. , Gröschel K. 
Published: May 2017

Background and purposeProlonged electrocardiogram (ECG) monitoring after ischaemic stroke increases the diagnostic yield of paroxysmal atrial fibrillation (pAF). In order to facilitate the additional workload involved in ECG analysis due to prolonged monitoring times, we investigated the effectiveness of pAF detection with an automated software algorithm (SA) in comparison to the routine staff‐based analysis (RA) during standard stroke‐unit care. Therefore, patients with acute ischaemic stroke or transitory ischaemic attack presenting with sinus rhythmus on the admission ECG and no history of atrial fibrillation were prospectively included.MethodsA 24‐h Holter ECG assessment was performed using either RA based on a computer‐aided evaluation and subsequent review by a cardiologist or a commercially available automated SA. In the case of discordant results concerning the occurrence of pAF between the two methods, the data underwent an independent external rating.ResultsOf 809 prospectively enrolled patients, 580 patients fulfilled the inclusion criteria. pAF was ultimately diagnosed in 3.3% of the cohort (19 patients). SA and RA correctly diagnosed pAF in 17 patients resulting in a comparable diagnostic effectiveness of the analysis methods (sensitivity: SA 89.5% vs. RA 89.5%; specificity: SA 99.3% vs. RA 99.1%; κ, 0.686; P < 0.001; 95% confidence interval, 0.525–0.847). RA revealed clinically relevant ECG abnormalities in an additional seven patients.ConclusionsAlthough it should not completely replace RA, SA‐based evaluation of Holter ECG reaches a high diagnostic effectiveness for the detection of pAF and can be used for a rapid and resource‐saving analysis of ECG data to deal with prolonged monitoring times.
The Italo‐Abyssinian Crisis and Australian Settler Colonialism in 1935
Authors: Paisley Fiona 
Published: May 2017

AbstractBy exploring the themes of settler colonialism and modernity in Australian commentary about Italy's invasion of Abyssinia in 1935, this paper sets out to consider Italy's war in north Africa as an international crisis with significance for Australian progressive narratives about Aboriginal conditions, status and rights important to Australia's international reputation. Thus, Australia's role as a member of the League and a mandatory power will be read in the context of international debate about Italy, modernity, race and violence.My case study draws from the experiences of Bessie Rischbieth, alternate delegate for Australia to the League of Nations in 1935, who observed the Abyssinian protest being made before the Assembly. Rischbieth was seemingly persuaded by Italy's claims to the right to land and territory in the context of immigration restrictions into the United States (and we might add, in relation to Australia) and was provided evidence of slavery in Abyssinia mobilised by Italy and earlier by the Anti‐Slavery Society in London in defence of the civilising influence of Europe upon a fellow (non‐European) member of the League. However, Rischbieth was also an activist within liberal humanitarian networks critical of Aboriginal policy in Australia in this same era. Her responses to the crisis in African and League affairs offer some insight into the proximities between settler colonialism in Australia and the ‘race’ issues raised by the annexation of Abyssinia by Italy, and its implications for collective security and global governance.
Legal Narratives, Human Trafficking and Slavery in Australia
Authors: Burn Jennifer 
Published: May 2017

AbstractIn this paper, I will explore the Australian context of human trafficking and slavery by reviewing narratives drawn from two separate coronial inquiries into the deaths of two people who were never legally recognised as being trafficked into Australia. Puongtong Simaplee died in Villawood Detention Centre in Sydney on 26 September 2001, and Manjit Singh died on 26 August 2011 in the intensive care unit of a Sydney hospital from complications of surgery.
Horizontal Dip‐Spin Casting of aqueous alumina‐polyvinylpyrrolidone suspensions with chopped fiber
Authors: Wiesner Valerie , Acosta Manuel , Rueschhoff Lisa , Youngblood Jeffrey , Trice Rodney 
Published: May 2017

AbstractA novel ceramic processing method, called Horizontal Dip Spin Casting (HDSC), enabled fabrication of tubular ceramic parts with an aligned chopped fiber phase. HDSC was demonstrated using highly loaded aqueous alumina suspensions with >50 vol.% solids loading and ≤5 vol.% water‐soluble polymer employed as a rheological modifier. Chopped carbon fibers were added to the suspensions to attain maximum loadings of 30 vol.%. During forming, cylindrical foam molds were dipped into the suspension while being rotated radially about the long axis. Simultaneously, a doctor blade was placed at a specified distance from the foam surface to facilitate the flow of the suspension to align the fiber and control the thickness of the material that accrued on the mold. Rheological study of alumina‐PVP suspensions with and without chopped carbon fiber showed that the suspensions exhibited a yield‐pseudoplastic flow behavior. The degree of alignment of the carbon fiber phase in the green bodies was characterized for various suspension formulations, carbon fiber contents and forming speeds. Stereological characterization of green body specimens confirmed the effectiveness of HDSC to attain the desired tubular geometry with considerable fiber alignment for a suspension composition containing ≤20 vol.% chopped fibers.
Effects of 1‐methylcyclopropene on postharvest storage performance and the transcriptome of cactus pear fruit
Authors: Li Li , Kashash Yael , Goldenberg Livnat , Sabag Amit , Doron‐Faigenboim Adi , Porat Ron 
Published: May 2017

SummaryPrestorage exposure to the ethylene‐action inhibitor 1‐methylcyclopropene (1‐MCP) at a concentration of 1 μL L−1 at 20 °C for 24 h significantly retarded peel color change and reduced decay development of cactus pear fruit after 3 weeks of cold storage at 7 °C and 5 days at 20 °C. Exposure to 1‐MCP had no significant effects on other fruit‐quality attributes, including firmness, weight loss, total soluble solids and acidity levels, and flavor. Exposure to 1‐MCP significantly reduced fruit respiration and ethylene production rates. RNA sequencing analysis revealed that 1‐MCP mitigated the overall changes in the transcriptome of cactus pear fruit upon cold storage. Functional categorization analysis using the MapMan software revealed that the most pronounced effects of 1‐MCP were in averting the massive down‐regulation of transcripts belonging to stress, RNA and transcription, signaling and cell categories. Furthermore, exposure to 1‐MCP significantly reduced pheophytinase and chlorophyllase transcript levels and increased chitinase transcript levels, thus providing molecular evidence for its observed effects on retardation of peel color change and enhancement of pathogen resistance. In commercial practice, 1‐MCP could be applied to cactus pear fruit in order to retard ripening and reduce decay development.
Assessing the effects of incorporating bubbles into the water used for cleaning operations relevant to the food industry
Authors: Burfoot Dean , Limburn Robert , Busby Ryan 
Published: May 2017

SummaryThese studies examined the effects of incorporating bubbles of air in the water used for cleaning surfaces. Small (<50 μm) or large (millimetre) bubbles were used, and these could aid cleaning by a scrubbing action, energy release or free radical production. Small or large bubbles improved the removal of biofilm from steel surfaces by 1.0 log10 or 1.6 log10, respectively. Biofilm removal from a polypropylene pipe wall was improved by 0.9 log10 by incorporating bubbles into the cleaning water. Further trials showed increased removal of carbohydrate, fat and protein deposits from stainless steel by incorporating bubbles into the water. These results suggest that the use of air bubbles in water could provide small improvements in cleaning or potentially similar contamination removal using less water.
Factor Exposures of Foreign Equity Capital in a Domestic Stock Market: Evidence from Korea
Authors: Sun Lingxia , Lee Dong Wook 
Published: May 2017

AbstractIn this paper, we examine the factor exposures of foreign equity capital in a domestic stock market in order to understand its risk‐taking behavior and sources of returns in the market. Using data from Korea for the 1999–2013 period, we find that foreigners are strongly exposed to the idiosyncratic volatility (IVOL) factor, which is long on low‐IVOL stocks and short on high‐IVOL stocks. That is, foreign equity capital is typically allocated to low‐IVOL stocks and profits from the return differential between low‐IVOL and high‐IVOL stocks. We also find that foreign equity capital moves in a way that it is loaded more on the IVOL factor when the IVOL factor premium is larger. We discuss the comparative advantage of foreign equity capital in bearing the IVOL factor risk and the role of information asymmetry between locals and foreigners in this risk sharing. We also provide additional empirical results that support our interpretation.
A modeling framework for incorporating DEA efficiency into set covering, packing, and partitioning formulations
Authors: Georgantzinos S. K. , Giannikos I. 
Published: May 2017

AbstractThe development of a modeling framework for efficient and cost‐effective decisions considering the set covering, packing, and partitioning problems is the main concern of this paper. To achieve this goal, the simultaneous data envelopment analysis model is combined with the appropriate covering‐type formulation providing a series of multiobjective mathematical models. Simple numerical examples are implemented and analyzed in order to validate and test the proposed models. The results demonstrate that the methods are able to successfully find solutions for set covering, packing, and partitioning problems that also take into account the efficiency of the coverage offered.
Multicriteria ABC inventory classification using acceptability analysis
Authors: Li Zhi , Wu Xunbo , Liu Fan , Fu Yelin , Chen Ke 
Published: May 2017

AbstractThis paper introduces a new procedure for handling the multicriteria ABC inventory classification problem using stochastic multicriteria acceptability analysis. All possible preferences among the evaluation criteria have been considered. Due to the fact that even under certain preference, it is difficult to reach a group consensus on the exact weight values along with each criterion, we calculate preference‐specific intervals under each preference and then formulate a stochastic decision‐making problem. To tackle this problem, we consider different distribution functions of the intervals and then compute the holistic acceptability indices to classify stock‐keeping units. The results derived from our method are compared to the previous results to show the robustness and superiority of our method.
Biofilms and delayed healing – an in vitro evaluation of silver‐ and iodine‐containing dressings and their effect on bacterial and human cells
Authors: Bourdillon Katie A , Delury Craig P , Cullen Breda M 
Published: May 2017

AbstractThis study investigated whether there are differences in the ability of wound dressings to modulate certain factors known to affect wound healing. A selection of antimicrobial dressings (AQUACEL®Ag Extra™,AQUACEL®Ag+ Extra™,IODOFLEX™,ACTICOAT™7 and PROMOGRAN PRISMA™matrix) were tested for their effect on both bacterial bioburden and human dermal fibroblasts. Some dressings underwent further evaluation for activity againstPseudomonas aeruginosabiofilms using a colony‐drip flow reactor model. The ability of in vitro biofilms to produce proteases, and the effect of PROMOGRAN PRISMA matrix on such proteases, was also investigated. All antimicrobial dressings tested reduced vegetative bacterial load; however, only PROMOGRAN PRISMA matrix was able to significantly reduce biofilm populations (P= 0·01). Additionally, PROMOGRAN PRISMA matrix was the only dressing that did not inhibit dermal fibroblast growth. All other dressings were detrimental to cell viability. In vitro biofilms ofPseudomonas aeruginosawere demonstrated as being capable of releasing bacterial proteases into their surroundings, and incubation with PROMOGRAN PRISMA matrix led to a 77% reduction in activity of such proteases (P= 0·002). The unique ability of PROMOGRAN PRISMA matrix to reduce in vitro vegetative bacteria, biofilm bacteria and bacterial proteases while still allowing dermal fibroblast proliferation may help rebalance the wound environment and reduce the occurrence of infection.