bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasi‐spherical silver nanoparticles with high dispersity and uniform sizes: preparation, characterization and bioactivity in their interaction with bovine serum albumin
Authors: Jiang Shan , Liu Hua‐Zuo , Cai Wan‐Lin , Bai Ai‐min , Ouyang Yu , Hu Yan‐Jun 
Published: January 2016

AbstractA stepwise seeded growth route for the preparation of silver nanoparticles (AgNPs) is reported. In the process, silver nitrate was used as a precursor, with sodium borohydride as a reducing agent and trisodium citrate as both a reductant and stabilizer. The AgNPs were characterized using several methods, including UV–vis spectroscopy, X‐ray diffraction and transmission electron microscopy. The prepared AgNPs were quasi‐spherical and crystalline, with an average diameter of 21 nm. Interactions between the AgNPs and bovine serum albumin (BSA) were investigated using UV–vis, fluorescence spectroscopy and synchronous fluorescence spectroscopy (SFS). It was proved that the quenching mechanism is a static process. The binding constants and number of binding sites were calculated. The thermodynamic parameters implied that the binding process was spontaneous and the main driving force of the interaction was electrostatic. The results of the SFS indicated that the conformational change of BSA was induced by AgNPs. Copyright © 2016 John Wiley & Sons, Ltd.
Extracellular vesicles concentration is a promising and important parameter for industrial bioprocess monitoring
Authors: Zavec Apolonija Bedina , Kralj‐Iglič Veronika , Brinc Matjaž , Trček Tanja Ficko , Kuzman Drago , Schweiger Ana , Anderluh Gregor 
Published: January 2016

AbstractExtracellular vesicles (EVs) are membrane vesicles that are produced by cells to be released into their microenvironment. In this study, we present the EV concentration as a new factor for optimization of industrial bioprocess control. The release of EVs depends on many cell properties, including cell activation and stress status, and cell death. Therefore, the EV concentration might provide a readout for identification of the cell state and the conditions during a bioprocess. Our data show that the EV concentration increased during the bioprocess, which indicated deteriorating conditions in the bioreactor. This increase in EV concentration in the fermentation broth was the consequence of two different processes: cell activation, and cell death. However, the release of EVs from activated living cells had a much weaker impact on EV concentration in the bioreactor than those released during cell death. EVs and cells in the bioprocess environment were quantified by flow cytometry. The most accurate data were obtained directly from unprocessed samples, making the monitoring of the EV concentration a rapid, easy, and cheap method. These EV concentrations reflect the conditions in the bioreactor and provide new information regarding the state of the bioprocess. Therefore, we suggest EV concentration as a new and important parameter for the monitoring of industrial bioprocesses.
Epithelial ovarian cancer subtypes attributable to smoking in the Norwegian Women and Cancer Study, 2012
Authors: Licaj Idlir , Lukic Marko , Jareid Mie , Lund Eiliv , Braaten Tonje , Gram Inger Torhild 
Published: January 2016

AbstractAmong European women, ovarian cancer is the fifth most common cancer. Smoking is an established risk factor for mucinous tumors. We estimated the impact of smoking in Norwegian women using population attributable fractions (PAFs) of epithelial ovarian cancer (EOC), by invasiveness and by histological subtypes in the Norwegian Women and Cancer Study with an average of 13.2 years of follow‐up. During >2 million person‐years, a total of 915 incident EOC cases, of which 667 (73%) invasive and 248 (27%) borderline, were identified among 154,234 women aged 34–70 years at enrolment. Compared with never smokers, current smokers had a nonstatistically significant increased risk of mucinous tumors (hazard ratio [HR] = 1.67 [95% confidence interval, (CI), 0.96–2.96]) and more than twice statistically significant risk of borderline mucinous tumors (HR = 2.17 [95% CI, 1.06–4.45]). The corresponding PAF estimates were 16.5% for mucinous and 25% for borderline mucinous. We found that among middle‐aged women, one in six mucinous tumors and one in four borderline mucinous tumors could have been prevented if women did not smoke.
Dittrichia graveolens (L.) Greuter Essential Oil: Chemical Composition, Multivariate Analysis, and Antimicrobial Activity
Authors: Mitic Violeta , Stankov Jovanovic Vesna , Ilic Marija , Jovanovic Olga , Djordjevic Aleksandra , Stojanovic Gordana 
Published: January 2016

AbstractThe chemical composition and in vitro antimicrobial activities of Dittrichia graveolens (L.) Greuter essential oil was studied. Moreover, using agglomerative hierarchical cluster (AHC) and principal component analyses (PCA), the interrelationships of the D. graveolens essential‐oil profiles characterized so far (including the sample from this study) were investigated. To evaluate the chemical composition of the essential oil, GC‐FID and GC/MS analyses were performed. Altogether, 54 compounds were identified, accounting for 92.9% of the total oil composition. The D. graveolens oil belongs to the monoterpenoid chemotype, with monoterpenoids comprising 87.4% of the totally identified compounds. The major components were borneol (43.6%) and bornyl acetate (38.3%). Multivariate analysis showed that the compounds borneol and bornyl acetate exerted the greatest influence on the spatial differences in the composition of the reported oils. The antimicrobial activity against five bacterial and one fungal strain was determined using a disk‐diffusion assay. The studied essential oil was active only against Gram‐positive bacteria.
ChemInform Abstract: Structural Modulation of Anionic Group Architectures by Cations to Optimize SHG Effects: A Facile Route to New NLO Materials in the ATCO3F (A: K, Rb; T: Zn, Cd) Series.
Authors: Yang Guangsai , Peng Guang , Ye Ning , Wang Jiyang , Luo Min , Yan Tao , Zhou Yuqiao 
Published: January 2016

AbstractCrystals of KCdCO3F (I), RbCdCO3F (II), KZnCO3F (III), and RbZnCO3F (IV) are grown under subcritical hydrothermal conditions, using e.g. a 1:6:2 molar mixture of CdCl2, KF, and K2CO3 in H2O for KCdCO3F (autoclave, 220 °C, 5 d).
ChemInform Abstract: All Chemical Vapor Deposition Synthesis and Intrinsic Bandgap Observation of MoS2/Graphene Heterostructures.
Authors: Zhang Yanfeng , et al.  
Published: January 2016

AbstractMoS2/graphene monolayer vertical heterostructures are obtained by atmospheric pressure chemical vapor deposition of graphene (CVD) on Au foil using methane as precursor (H2/argon, 970 °C) followed by low‐pressure CVD of monolayer MoS2 triangles using MoO3 and sulfur as precursors.
ChemInform Abstract: V16N1.5: Metastable or Missing in the Binary Phase Diagram?
Authors: Widenmeyer Marc , Wessel Claudia , Dronskowski Richard , Niewa Rainer 
Published: January 2016

AbstractThree synthetic approaches besides the classical reaction of vanadium with flowing ammonia are evaluated for the preparation of V16N1.5: ammonolysis of β‐V2H, the reaction of vanadium and δ‐VN at elevated temperatures in sealed ampules, and the thermal decomposition of δ‐VN in dynamic vacuum at high temperatures.
ChemInform Abstract: Asymmetric Electrophilic α‐Amination of Silyl Enol Ether Derivatives via the Nitrosocarbonyl Hetero‐ene Reaction.
Authors: Sandoval David , Samoshin Andrey V. , Read de Alaniz Javier 
Published: January 2016

AbstractA highly diastereoselective nitrosocarbonyl hetero‐ene reaction of an in situ generated sultam derived nitrocarbonyl compound with silyl enol ethers offers a highly stereoselective entry to α‐amino ketone derivatives.
ChemInform Abstract: Pincer CNC Bis‐N‐heterocyclic Carbenes: Robust Ligands for Palladium‐Catalyzed Suzuki—Miyaura Arylation of Bromoanthracene and Related Substrates.
Authors: Zende V. M. , Schulzke C. , Kapdi A. R. 
Published: January 2016

AbstractThe novel pincer‐type NHC‐precursor (IPB) is efficiently used for arylation of anthracenes with aryl boronic acids.
ChemInform Abstract: Synthesis of Enantioenriched Alkylfluorides by the Fluorination of Boronate Complexes.
Authors: Sandford Christopher , Rasappan Ramesh , Aggarwal Varinder K. 
Published: January 2016

AbstractBoronates, generated in situ from chiral secondary boronic esters and phenyllithium, are enantiospecifically transformed into alkylfluorides by reaction with selectfluor II (SF2) in the presence of styrene as a radical trap.
ChemInform Abstract: Regioselective and Enantioselective Addition of Sulfur Nucleophiles to Acyclic α,β,γ,δ‐Unsaturated Dienones Catalyzed by an Iron(III)—Salen Complex.
Authors: Shaw Subrata , White James D. 
Published: January 2016

AbstractThis method allows for the highly enantioselective and regioselective δ‐addition of thiols and thioacetic acid to dienones.
ChemInform Abstract: Cycloalkene Carbonitriles in Rhodium‐Catalyzed 1,4‐Addition and Formal Synthesis of Vabicaserin.
Authors: Dziechciejewski Wojciech J. , Weber Regina , Sowada Oliver , Boysen Mike M. K. 
Published: January 2016

AbstractConditions for the scalable asymmetric 1,4‐addition of aryl boronic acids onto cyclopentene and cycloheptene carbonitrile and carboxylate are elaborated.
ChemInform Abstract: B(C6F5)3: A New Class of Strong and Bulky Lewis Acid for exo‐Selective Intermolecular Diels—Alder Reactions of Unreactive Acyclic Dienes with α,β‐Enals.
Authors: Zhou Jia‐Hui , Jiang Bing , Meng Fei‐Fan , Xu Yun‐He , Loh Teck‐Peng 
Published: January 2016

AbstractThe remarkable exo‐selectivities of most of the products may be due to steric interaction between the bulky Lewis acid and the substrates.
ChemInform Abstract: Silver‐Catalyzed Cross‐Coupling of Isocyanides and Active Methylene Compounds by a Radical Process.
Authors: Liu Jianquan , Liu Zhenhua , Liao Peiqiu , Zhang Lin , Tu Tao , Bi Xihe 
Published: January 2016

AbstractA broad variety of methylene compounds, including carbonyl, carboxyl, nitro, cyano, and sulfonyl group containing ones react with aryl isocyanides to form β‐aminoenones, which are most often formed exclusively as E‐isomers.
ChemInform Abstract: An Efficient Method for Syntheses of Functionalized 6‐Bulkysubstituted Salicylates under Microwave Irradiation.
Authors: Qu Ren‐Yu , Liu Yu‐Chao , Wu Qiong‐You , Chen Qiong , Yang Guang‐Fu 
Published: January 2016

AbstractA new efficient method for the synthesis of functionalized 4‐methyl‐6‐bulkyarylsalicylates via a microwave‐promoted Suzuki cross‐coupling is presented.
ChemInform Abstract: Imidazolin‐2‐ylidenaminophosphines as Highly Electron‐Rich Ligands for Transition‐Metal Catalysts.
Authors: Wuensche Marius A. , Mehlmann Paul , Witteler Tim , Buss Florenz , Rathmann Patrick , Dielmann Fabian 
Published: January 2016

AbstractThe design and synthesis of novel extremely electron rich phosphine ligands based on imidazolin‐2‐ylideneamine groups is detailed and their ability to catalyze the Suzuki coupling of chloroarenes is demonstrated.
ChemInform Abstract: Efficient and Convenient Method for Synthesis of Benzofuran‐3‐acetic Acids and Naphthafuran‐Acetic Acids.
Authors: Basanagouda Mahantesha , Narayanachar Narayanachar , Majati Iranna B. , Mulimani Shiddappa S. , Sunnal Satish B. , Nadiger Rohit V. , Ghanti Ashok S. , Gudageri Siddeshwar F. , Naik Ravi , Nayak Akshata 
Published: January 2016

AbstractThe base‐catalyzed Perkin rearrangement of coumarins of type (I) affords the corresponding benzofuran derivatives (II).
ChemInform Abstract: Iodine‐Promoted Sequential Michael and Oxidative Dehydrogenation Processes: Synthesis of Trisubstituted Methanes Containing a Coumarin and a Chromone Ring.
Authors: Hu Ya‐Jian , Jiang Neng , Xie Sai‐Sai , Li Su‐Yi , Lan Jin‐Shuai , Kong Ling‐Yi , Wang Xiao‐Bing 
Published: January 2016

AbstractVarious arylidenechromanones react with 4‐hydroxycoumarin affording the title methanes under air and environmentally benign conditions.
ChemInform Abstract: Organoselenium‐Catalyzed Synthesis of Indoles Through Intramolecular C—H Amination.
Authors: Zhang Xuelin , Guo Ruizhi , Zhao Xiaodan 
Published: January 2016

AbstractIndoles are prepared by intramolecular amination of 2‐alkenylanilines.The reaction of trisubstituted alkene (VII) gives indole (VIII) via 1,2—phenyl migration.
ChemInform Abstract: Chiral γ‐Lactams by Enantioselective Palladium(0)‐Catalyzed Cyclopropane Functionalizations.
Authors: Pedroni Julia , Cramer Nicolai 
Published: January 2016

AbstractEnantioselective Pd(0)‐catalyzed cyclization of N‐chloroacetyl substituted cyclopropylamines (I) and (III) offers a novel approach to cyclopropane fused chiral bicyclic pyrrolidines (II) and (IV) with moderate to good stereoselectivity.
ChemInform Abstract: Synthesis of 3,5‐Disubstituted‐1H‐pyrazoles from Acid Chlorides, Alkynes, and Hydrazine in the Presence of Silica‐Supported‐Zinc Bromide.
Authors: Keivanloo Ali , Bakherad Mohammad , Samangooei Shahrzad 
Published: January 2016

AbstractA one‐pot palladium‐ and copper‐free method is presented for the synthesis of 3,5‐disubstituted‐1H‐pyrazoles using silica‐supported zinc bromide as catalyst.
ChemInform Abstract: Stereoselective Synthesis of 4‐Substituted Cyclic Sulfamidate‐5‐phosphonates by Using Rh‐Catalyzed, Asymmetric Transfer Hydrogenation with Accompanying Dynamic Kinetic Resolution.
Authors: Seo Yeon Ji , Kim Jin‐ah , Lee Hyeon‐Kyu 
Published: January 2016

AbstractUsing formic acid/Et3N as H source, RhCl((R,R)‐TosDPEN)(Cp*)‐catalyzed asymmetric transfer hydrogenation of respective cyclic sulfamidate imine‐5‐phosphonates gives the title compounds in nearly quantitative yield and with excellent enantioselectivities.
ChemInform Abstract: Efficient Protocol for Synthesis of Pyrazolo[3,4‐a]acridines.
Authors: Satheeshkumar Rajendran , Kaminsky Werner , Sparkes Hazel A. , Rajendra Prasad Karnam Jayarampillai 
Published: January 2016

AbstractSix title compounds of type (VI) are prepared by a three‐step reaction sequence.
ChemInform Abstract: Cycloaddition of Cyclobutenone and Azomethine Imine Enabled by Chiral Isothiourea Organic Catalysts.
Authors: Li Bao‐Sheng , Wang Yuhuang , Jin Zhichao , Chi Yonggui Robin 
Published: January 2016

AbstractThe title reaction affords nitrogen‐containing heterocycles with excellent diastereo‐and enantioselectivities and provides a new reaction pattern for C—C bond activation.
ChemInform Abstract: Asymmetric Epoxidation of Alkylidenemalononitriles: Key Step for One‐Pot Approach to Enantioenriched 3‐Substituted Piperazin‐2‐ones.
Authors: Meninno Sara , Vidal‐Albalat Andreu , Lattanzi Alessandra 
Published: January 2016

AbstractAn enantioselective epoxidation of alkylidenemalononitriles using a cinchona‐derived thiourea as the organocatalyst and cumyl hydroperoxide as the oxidant is reported.
ChemInform Abstract: Cyclopropenes for the Synthesis of Cyclopropane‐Fused Dihydroquinolines and Benzazepines.
Authors: Luo Hui‐Xin , Niu You‐Hong , Cao Xiao‐Ping , Ye Xin‐Shan 
Published: January 2016

AbstractA novel Povarov‐type three‐component reaction of cyclopropenes, anilines, and aromatic aldehydes is efficiently catalyzed by TfOH leading to desired cyclopropane‐fused dihydroquinolines (IV) and (VIII), which are converted into N‐triflated benzazepines (VI) and (IX), resp., via a ring opening/isomerization reaction.
ChemInform Abstract: Dicarabrol, a New Dimeric Sesquiterpene from Carpesium abrotanoides L.
Authors: Wang Jun‐Feng , He Wei‐Jun , Zhang Xiao‐Xiao , Zhao Bi‐Qing , Liu Yong‐Hong , Zhou Xiao‐Jiang 
Published: January 2016

AbstractDicarabrol (I) is isolated from the whole plant of Carpesium abrotanoides L.
ChemInform Abstract: Merosesquiterpenoids and Ten‐Membered Macrolides from a Soft Coral‐Derived Lophiostoma sp. Fungus.
Authors: Zheng Cai‐Juan , Shao Chang‐Lun , Chen Min , Niu Zhi‐Gang , Zhao Dong‐Lin , Wang Chang‐Yun 
Published: January 2016

Abstractisolation, structure elucidation and biological activities of a new merosesquiterpenoid, craterellin D (I), its analogue craterellin A, and five known ten‐membered macrolides
ChemInform Abstract: Glycoconjugates of Polyhedral Boron Clusters
Authors: Satapathy Rashmirekha , Dash Barada P. , Mahanta Chandra Sekhara , Swain Biswa Ranjan , Jena Bibhuti Bhusan , Hosmane Narayan S. 
Published: January 2016

AbstractReview: recent advances in the synthesis and utilization; 78 refs.
Permittivity measurement of liquids, powders, and suspensions using a parallel‐plate cell
Authors: Kordzadeh Atefeh , De Zanche Nicola 
Published: January 2016

ABSTRACTThis work describes the measurement of complex permittivity (or dielectric constant) of powders (water insoluble), solutions, and suspensions using a parallel‐plate capacitor cell. An impedance analyzer measures the cell's impedance at radio frequencies used in nuclear magnetic resonance and magnetic resonance imaging (10–300 MHz) through an appropriate test fixture. The cell's impedance is fitted to an equivalent circuit using a Matlab script or other software, and the permittivity of the material is extracted after calibration with known materials. The permittivity of the solid material is obtained from that of the powder suspension using known mixing rules. Measurements for most materials tested are in agreement with those obtained using standard coaxial probes. Some discrepancies are observed for loose powders because of the difficulty of controlling the amount of packing. For high‐permittivity materials or conductive solutions an enhanced equivalent circuit has been found that characterizes the cell's behavior over the full frequency range. © 2016 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 46B: 19–24, 2016
Mirror Symmetry Breaking by Chirality Synchronisation in Liquids and Liquid Crystals of Achiral Molecules
Authors: Tschierske Carsten , Ungar Goran 
Published: January 2016

AbstractThe front cover artwork is provided by the group of Carsten Tschierske, Martin Luther University, Halle‐Wittenberg. The image shows a liquid conglomerate, as observed between slightly uncrossed polarizers; the dark and bright areas correspond to domains rotating the plane of linearly polarized light in opposite directions. Representative enantiomorphic helical conformers and an illustration of twisted molecular stacking are superimposed. Read the full text of the Minireview at 10.1002/cphc.201500601
Shuttling as a Strategy to Control the Regiochemistry of Bis‐Additions on Fullerene Derivatives
Authors: Carini Marco , Da Ros Tatiana , Prato Maurizio , Mateo‐Alonso Aurelio 
Published: January 2016

AbstractThe reactivity of a fullerene‐stoppered rotaxane, a C60 monoadduct, towards a second cycloaddition reaction is explored. The close proximity of the macrocycle to the fullerene sphere is able to allosterically influence the second cycloaddition reaction, giving rise to a selected mixture of bis‐adducts.
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists
Authors: Chen Kaiwen W. , Bezbradica Jelena S. , Groß Christina J. , Wall Adam A. , Sweet Matthew J. , Stow Jennifer L. , Schroder Kate 
Published: January 2016

Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR‐dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type‐specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in murine neutrophils, in comparison to well‐established NLRP3 signalling pathways in macrophages. Here, we demonstrate that while murine neutrophils can indeed signal via the NLRP3 inflammasome, neutrophil NLRP3 selectively responds to soluble agonists but not to the particulate/crystalline agonists that trigger NLRP3 activation in macrophages via phagolysosomal rupture. In keeping with this, alum did not trigger IL‐1β production from human PMN, and the lysosomotropic peptide Leu‐Leu‐OMe stimulated only weak NLRP3‐dependent IL‐1β production from murine neutrophils, suggesting that lysosomal rupture is not a strong stimulus for NLRP3 activation in neutrophils. We validated our in vitro findings for poor neutrophil NLRP3 responses to particles in vivo, where we demonstrated that neutrophils do not significantly contribute to alum‐induced IL‐1β production in mice. In all, our studies highlight that myeloid cell identity and the nature of the danger signal can strongly influence signalling by a single PRR, thus shaping the nature of the resultant immune response.
Lean mass predicts conditioned pain modulation in adolescents across weight status
Authors: Stolzman S. , Hoeger Bement M. 
Published: January 2016

AbstractBackgroundThere is a wide continuum of conditioned pain modulation (CPM) in adults with older adults experiencing an attenuatedCPMresponse compared with younger adults. Less is known for adolescents and the role of anthropometrics.MethodsFifty‐six adolescents (15.1 ± 1.8 years; 32 normal weight and 24 overweight/obese; 27 boys) completed in aCPMsession that included anthropometric testing. Pressure pain thresholds were measured at the nailbed and deltoid muscle (test stimuli) with the foot submerged in a cool or ice water bath (conditioning stimulus). Weight status, body composition (Dual‐energy X‐ray absorptiometry scan), physical activity levels and clinical pain were also evaluated.ResultsTheCPMresponse in adolescents was similar across sites (nailbed vs. deltoid), weight status (normal vs. overweight/obese) and sex.CPMmeasured at the deltoid muscle was positively associated with left arm lean mass but not fat mass; lean mass of the arm uniquely predicted 10% of theCPMmagnitude.CPMmeasured at the nailbed was positively correlated with physical activity levels.ConclusionsThese results suggest that lean mass and physical activity levels may contribute to endogenous pain inhibition in adolescents across weight status.
Seismic response analysis of an interacting curved bridge–train system under frequent earthquakes
Authors: Zeng Qing , Dimitrakopoulos Elias G. 
Published: January 2016

SummaryThis paper establishes a scheme for the seismic analysis of interacting vehicle–bridge systems. The focus is on (horizontally) curved continuous railway bridges and frequent earthquakes. Main features of the proposed scheme are (i) the treatment of the dynamics in all three dimensions (3D), employing an additional rotating system of reference to describe the dynamics of the vehicles and a realistic 3D bridge model; (ii) the simulation of the creep interaction forces generated by the rolling contact between the wheel and the rail; and (iii) the integration of the proposed scheme with powerful commercial finite element software, during the pre‐processing and post‐processing phases of the analysis. The study brings forward the dynamics of a realistic vehicle–bridge (interacting) system during seismic shaking. For the (vehicle–bridge) case examined, the results verify the favorable damping effect the running vehicles have on the vibration of the deck. By contrast, the study stresses the adverse influence of the earthquake‐induced bridge vibration on the riding comfort but, more importantly, on the safety of the running vehicles. In this context, the paper unveils also a vehicle–bridge–earthquake timing problem, behind the most critical vehicle response, and underlines the need for a probabilistic treatment. Among the 20 sets of historic records examined, the most crucial for the safety of the vehicles are near‐fault ground motions. Finally, the study shows that even frequent earthquakes, of moderate intensity, can threaten the safety of vehicles running on bridges during the ground motion excitation, in accordance with recorded accidents. Copyright © 2016 John Wiley & Sons, Ltd.