bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D receptor gene FokI polymorphism in Egyptian children and adolescents with SLE: A case-control study
Authors: Imam A A , Ibrahim H E , Farghaly M A A , Alkholy U M , Gawish H H , Abdalmonem N , Sherif A M , Ali Y F , Hamed M E , Waked N M , Fathy M M , Khalil A M , Noah M A , Hegab M S , Ibrahim B R , Nabil R M , Fattah L A 
Published: August 2017

Background Childhood-onset systemic lupus erythematosus (cSLE) is a lifelong autoimmune disorder. The vitamin D receptor (VDR) gene is a potential candidate gene for cSLE susceptibility. In this study, we aimed to investigate the FokI polymorphism in the VDR gene in Egyptian children and adolescents with SLE, to determine whether this polymorphism could be a genetic marker for cSLE susceptibility or disease activity and we also measured the serum level of 25-hydroxyvitamin D [25(OH) D] to assess its relation to such polymorphism. Methods This was a case-control study, which included 300 patients with cSLE and 300 age, sex, and ethnicity-matched healthy controls. All participants were genotyped for the VDR gene FokI (rs2228570) polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while the serum [25(OH) D] levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The VDR FokI FF genotype and F allele were overrepresented among cSLE patients compared with the controls, [odds ratio (OR) = 2.7; 95% confidence interval (CI): 1.6–4.4 for the FF genotype; p = 0.000; and OR = 1.6; 95% CI: 1.27–2.05 for the F allele; p = 0.000, respectively]. We found a significant association between VDR FokI FF genotype with lupus nephritis (OR: 4.8; 95% CI: 2.2–10.6; p = 0.002); and high disease activity index score ( p = 0.01). Conclusions The FokI polymorphism in the VDR gene may contribute to susceptibility to SLE in Egyptian children and adolescents. Moreover, the FF genotype constituted a risk factor for the development of lupus nephritis and was associated with low serum [25(OH) D] levels as well as higher disease activity index score among studied patients with cSLE.
A polymorphic GGC repeat in the NPAS2 gene and its association with melanoma
Authors: Franzoni Alessandra , Markova-Car Elitza , Dević-Pavlić Sanja , Jurišić Davor , Puppin Cinzia , Mio Catia , De Luca Marila , Petruz Giulia , Damante Giuseppe , Pavelić Sandra Kraljević 
Published: August 2017

Circadian clock regulation in mammals is controlled by feedback loops of a set of circadian genes. One of these circadian genes, NPAS2, encodes for a member of the bHLH-PAS class of transcription factors and is expressed in the forebrain and in some peripheral organs such as liver and skin. Other biological processes are also regulated by circadian genes. For example, NPAS2 is involved in cell proliferation, DNA damage repair and malignant transformation. Aberrant expression of clock genes has been previously observed in melanoma which led to our effort to sequence the NPAS2 promoter region in this cancer type. The NPAS2 putative promoter and 5′ untranslated region of ninety-three melanoma patients and ninety-six control subjects were sequenced and several variants were identified. Among these is a novel microsatellite comprising a GGC repeat with different alleles ranging from 7 to 13 repeats located in the 5′ untranslated exon. Homozygosity of an allele with nine repeats (9/9) was more prevalent in melanoma than in control subjects (22.6% and 13.5%, respectively, P: 0.0206) suggesting that some NPAS2 variants might contribute to melanoma susceptibility. Impact statement This report describes a variable microsatellite repeat sequence located in the 5′ untranslated exon of NSPAS2, a gene encoding a clock transcription factor. Significantly, this study is the first to show that a variant copy number GGC repeat sequence in the NPAS2 clock gene associates with melanoma risk and which may be useful in the assessment of melanoma predisposition.
Clinical Outcome Reporting in Youth ACL Literature Is Widely Variable
Authors: Brusalis Christopher M. , Lakomkin Nikita , Suryavanshi Joash R. , Cruz Aristides I. , Green Daniel W. , Jones Kristofer J. , Fabricant Peter D. 
Published: August 2017

Background: Advances in anterior cruciate ligament (ACL) reconstruction procedures in pediatric and adolescent patients have resulted in an increase in recent clinical studies on this topic. However, the consistency with which outcome measures are reported in this demographic is unknown. Purpose: To document outcome reporting patterns of youth ACL reconstruction studies in high-impact journals. Study Design: Systematic review; Level of evidence, 4. Methods: All articles published in 5 high-impact orthopaedic journals from 2010 to 2016 were reviewed to identify those reporting clinical outcomes of young patients who underwent ACL reconstruction. Studies that were nonclinical, reported on patients older than 18 years, or included fewer than 10 patients were excluded. Outcome measures used in all included studies were recorded. Results: Seventeen studies encompassing 772 subjects (mean age, 14.3 years; range, 6.3-18.0 years) were analyzed. Eight studies (47%) reported on Tanner stage of subjects, while 1 study reported skeletal age. Ten studies (59%) clearly documented the presence or absence of surgical complications. Range of motion was reported in 65% of studies. Leg-length discrepancy and angular deformity were each reported in 76% of studies, with 12% quantifying results through radiographic measurements. Ligament testing was variably defined by inclusion of instrumented testing (65%), Lachman test (53%), and pivot-shift test (53%). Fourteen studies (82%) explicitly reported on the rate of ACL rerupture, while 71% reported on the rate of revision surgery. Rate of return to preinjury activity was reported in 8 studies (47%), of which 2 defined criteria for return to sport and 3 defined the level of competitive sport. Patient-reported outcome measures (PROMs) were used variably. For the 3 most commonly reported PROMs (Lysholm, International Knee Documentation Committee, and Tegner), 24% of studies reported all 3 PROMs, 35% of studies reported 2 PROMs, and 6% of studies reported 1 PROM in isolation. A pediatric-specific PROM was reported in 1 of the 17 studies. Conclusion: Studies on pediatric ACL reconstruction published in high-impact journals unreliably defined subjects’ skeletal maturity, inconsistently reported on objective outcome measures, and used disparate adult-validated PROMs to assess subjective outcomes. These findings highlight the need for standardized, pediatric-specific outcome measures to be applied in future studies evaluating ACL reconstruction in children and adolescents.
Patient experience of lung volume reduction procedures for emphysema: a qualitative service improvement project
Authors: Buttery Sara , Lewis Adam , Oey Inger , Hargrave Joanne , Waller David , Steiner Michael , Shah Pallav L. , Kemp Samuel V. , Jordan Simon , Hopkinson Nicholas S. 
Published: August 2017

The aim of this service improvement project was to gain understanding of the patient experience of lung volume reduction surgery (LVRS) and endobronchial valve (EBV) placement, from referral through to post-discharge care.
Focus group interviews were carried out in two tertiary centres in London and Leicester, UK. Sixteen patients who had undergone lung volume reduction surgery (LVRS), endobronchial valve (EBV) placement, or both, were recruited. Prior to participation in each focus group, participants completed a questionnaire to guide and focus discussion. Thematic analysis identified common themes to the participant experience of receiving lung volume reduction interventions.
Themes included patient focus on declining health and the need to �fight� for a referral; consequences of having procedures and potential unexpected complications; and vulnerability post discharge and limited continuity of care. Participants were clear that the benefits of having had either LVRS or EBV procedures outweighed any difficulties experienced. Participants were keen to have further similar interventions if appropriate.
These data confirm the need to develop more systematic lung volume reduction pathways, provide appropriate information, and ensure that post-discharge care is optimal.
Cash Conversion Systems in Corporate Subsidiaries
Authors: Chen Weiwei , Melamed Benjamin , Sokolinskiy Oleg , Sopranzetti Ben 
Published: August 2017

This paper models a cash conversion system in a subsidiary of a parent company where there is an active internal capital market, but otherwise the subsidiary has no access to additional external funds. The cash conversion system consists of a treasury, a single-product make-to-stock inventory, and a receivables pool. It implements a perpetual flow cycle, where funds convert to product and back to funds. The system is stationary, and revenues and costs flow directly to the parent company. The parent company aims to maximize equilibrium (long-run) financial metrics in terms of net profit rate and rate of return. To this end, we model this system as a discrete-state continuous-time Markov process and compute its equilibrium state distribution using analytic and numerical methods. These are then used to derive statistics of the equilibrium cash conversion cycle and define equilibrium financial rate metrics and cumulative counterparts that incorporate the time value of money. We further optimize the financial and operational designs of the system and, specifically, the internal capital allocation and inventory base stock level. Finally, noting the potential for friction in the parent–subsidiary relationship, we study numerically the impact of moral hazard and internal capital market inefficiency on optimal designs. The online appendix is available at https://doi.org/10.1287/msom.2017.0625 .
DISEÑO E IMPLEMENTACIÓN DE UN BANCO DE CARGA MONOFÁSICO PARA PRUEBAS DE CARGA EN SISTEMAS DE ALIMENTACIÓN ININTERRUMPIDAS MONOFÁSICAS CON CAPACIDADES ENTRE 1 Y 2 KVA
Authors: Rozo García Pablo Emilio , Zabaleta Judith , Vera Parra Nelson Enrique 
Published: August 2017

En este documento se describe el proyecto correspondiente a el diseño e implementación de un banco de carga de tipo resistivo para pruebas de carga en Sistemas de alimentación ininterrumpidas monofásicas de capacidades comprendidas entre 1 KVA y 2 KVA. La estructura del proyecto presenta inicialmente la descripción teórica sobre los conceptos fundamentales en electrónica de potencia y en referencia con los bancos de carga que se encuentran actualmente en el mercado. Posteriormente se realiza el diseño del banco de carga resistivo con base en la investigación ya existente y finalmente se implementa el diseño, resaltando los resultados obtenidos, conclusiones, dificultades técnicas y mejoras al proyecto. A partir de los resultados obtenidos, se entrega una herramienta de trabajo para la industria de sistemas de potencia en general y material de investigación en áreas relacionadas con el análisis de la calidad de energía y electrónica de potencia.
AUTOMATIZACIÓN DEL PROCESO DE PALETIZADO DE LA CELDA HAS-200
Authors: Granada Iván Mauricio , Turizo Jhony , Porras Jorge Eduardo , Santa Fernando Martínez 
Published: August 2017

El sistema HAS-200 se ha desarrollado teniendo en cuenta las necesidades que la industria requiere en capacitación, dado los altos niveles de automatización que se están implantando. La versatilidad y diseño de este sistema logran representar una planta de fabricación con todos los procesos de una manera real, en este proyecto se abordo un proceso que en la versión actual de la maquina no se tenía contemplado, pero si hace parte de todas las industrias y es el final de cualquier línea de producción, el paletizado, que consiste en disponer los productos finales de tal manera que se facilite su proceso de embalaje, despacho y control de almacén. El desarrollo se fundamento en la base de datos que maneja la HAS-200, en esta se encuentra toda la información referente a la producción incluyendo la identificación del cliente para quien se ordeno el producto, que fue el parámetro escogido para realizar el proceso de paletizado. Como resultado se obtuvo una aplicación capaz de realizar la conexión con la base de datos, para accesarla y realizar la consulta pertinente además de visualizar el estado del almacén, la automatización se implemento con un brazo robótico y los elementos de sensado e identificación del producto, alcanzando una autonomía total del proceso, obteniendo con esto un nuevo modulo para la celda de fabricación flexible, y cerrando por completo el ciclo de producción que se pretende emular mediante la HAS-200.
ACOPLAMIENTO EXCITATORIO E INHIBITORIO DE NEURONAS PULSANTES ACOPLADAS
Authors: Segovia Chaves Francis Armando , Corrales Martínez Silvia Catalina 
Published: August 2017

La información es representada como patrones de actividad neuronal o pulsos, lo que crea una diferencia significante entre las redes neuronales pulsantes y las redes neuronales clásicas. Una característica diferente de las redes neuronales pulsantes es que la información es codificada en patrones de actividad neuronal y estas se comunican usando trenes de pulsos en lugar de valores individuales. Además, este tipo de redes neuronales pulsantes trabajan con una gran cantidad de neuronas donde se requiere grandes recursos computacionales para ser simuladas. En el presente trabajo se realiza un análisis teórico de las redes neuronales pulsantes, para el caso de dos neuronas acopladas. Se logra obtener teóricamente las condiciones para acoplamiento excitatorio e inhibitorio en las neuronas.
PROTOTIPO PARA EL ANÁLISIS DEL RENDIMIENTO EN EL TRÁFICO DE UN SERVICIO BROADCAST UTILIZANDO LOS PROTOCOLOS HTTP Y RTP SOBRE IPV6 EN UNA RED ACADÉMICA DE TECNOLOGÍA AVANZADA
Authors: Ferro Roberto , Cortes F. Ernesto A. , Martínez A. Carlos A. , Barbosa Juan P. 
Published: August 2017

En el presente artículo se condensan los resultados obtenidos de la implementación y modelado de un Prototipo de Servicio Streaming sobre el Sistema Operativo Fedora 13 con el Programa VLC en la Red de Investigación y Tecnología Avanzada de la Universidad Distrital RITA-UD sobre IPV6 utilizando como cliente la Universidad Minuto de Dios vía RUMBO mediante un Tunel 6a4.
STUDI POTENSI PEMBANGKIT LISTRIK MINIHYDRO SISTEM TRANSMISI AIR BAKU PDAB UNIT BREGAS
Authors: Rezagama Arya , Hadiwidodo Mochtar 
Published: August 2017

Distribusi pelayanan listrik di Indonesia hingga kini masih belum merata. Banyak desa-desa di pegunungan yang masih terbatas dalam mengakses pasokan listrik. Salah satu alternatif solusinya ialah dengan memanfaatkan beda ketinggian sistem perpipaan transmisi air baku. Jaringan transmisi PDAB Tirta Utama Jateng Unit Bregas teridiri atas tiga jalur perpipaan meliputi jalur Eksisting, Bregas I, dan Bregas II memiliki 34 Bak Pelepas Tekan yang bisa ditanamkan Pembangkit Listrik Minihydro. Survei lapangan dilakukan dari mata air hingga lokasi Reservoir Yamansari menggunakan GPS. Pengukuran debit aliran pipa menggunakan alat Ultrasonik Flowmeter. Analisis hidrolika perpipaan dihitung dengan formula Hazen-Williams. Alternatif lokasi terbaik yang akan dimanfaatkan potensinya sebagai pembangkit listrik tenaga mikrohidro/minihidro adalah ruas perpipaan BPT III A – BPT III B pada jalur Bregas I dengan potensi daya yang dihasilkan 434,24 kW, kemudian ruas perpipaan Chamber Kalibakung – BPT III A pada jalur Bregas I dengan potensi daya yang dihasilkan 303,71 kW. Kondisi jalur Bergas II masih belum optimal dimana debit yang beroperasi sekarang hanya 150 l/det dapat ditingkatkan menjadi 250 l/det. Ruas perpipaan BPT 6 – BPT 7 pada jalur Bregas II dengan potensi daya yang dihasilkan 227 kW. Sedangkan sistem Bergas Eksisting tidak direkomendasikan untuk PLTM karena kondisi pipa yang sudah buruk dan kehandalan debit yang kurang baik dari sumbernya.
Treinamento de habilidades sociais como combate à homofobia: um relato de experiência
Authors: Sousa Kelyane Oliveira , França Dalila Xavier 
Published: August 2017

O presente estudo teve como objetivo relatar a experiência de um Programa de Treinamento voltado para a promoção de habilidades sociais utilizadas como estratégia de combate à homofobia. Participaram 22 adolescentes, de ambos os sexos, com idades entre 14 e 17 anos, alunos de uma escola pública do município de Aracaju, Sergipe. O programa foi composto por 10 sessões semanais de 50 minutos e contou com uma abordagem psicoeducativa e cognitivo-comportamental, através de diversas técnicas e atividades voltadas para o universo do adolescente. Os resultados apontaram uma boa aceitabilidade por parte dos adolescentes e maior conhecimento da temática “diversidade sexual”, que antes era desconhecida para o referido público. Sua eficácia foi observada através da mudança verificada nas atitudes e comportamentos dos adolescentes na direção da promoção de habilidades sociais relacionadas à homofobia, já que os jovens se mostraram mais abertos a se relacionarem de forma mais respeitosa com pessoas que fogem à norma da heteronormatividade no seu convívio social.
The use of ἀνίστημι and ἐγείρω and the “Resurrection of a Soul”
Authors: Cook John Granger 
Published: August 2017

Abstract:
There are no explicit uses of ψυχή or πνεῦμα with ἀνίστημι, ἀνάστασις, ἐγείρω or ἔγερσις in a text that refers to resurrection until those mentioned by some Gnostic sources and heresiologists in their discussions of Gnostic groups in the second and following centuries. In texts from Second Temple Judaism and paganism, which describe a person’s return to life, ἐγείρω and so forth are used for the resurrection of a body. This thesis has significant implications for the interpretation of Dan 12,2 and 1Cor 15,3–5.
Exercise Technique: The Push Press
Authors: Bishop Chris , Chavda Shyam , Turner Anthony 
Published: August 2017

ABSTRACT
THE PUSH PRESS EXERCISE HAS OFTEN BEEN USED BY COACHES AS ONE OF MANY TOOLS TO ENHANCE AN ATHLETE'S PHYSICAL DEVELOPMENT. RECENT RESEARCH HAS FURTHER VALIDATED THIS EXERCISE TO AUGMENT POWER DEVELOPMENT. THE AIM OF THIS PAPER IS TO OUTLINE THE BENEFITS THIS EXERCISE HAS FOR STRENGTH AND CONDITIONING COACHES.
When Does Frequency-Independent Selection Maintain Genetic Variation?
Authors: Novak Sebastian , Barton Nicholas H 
Published: August 2017

Abstract
Frequency-independent selection is generally considered as a force that acts to reduce the genetic variation in evolving populations, yet rigorous arguments for this idea are scarce. When selection fluctuates in time, it is unclear whether frequency-independent selection may maintain genetic polymorphism without invoking additional mechanisms. We show that constant frequency-independent selection with arbitrary epistasis on a well-mixed haploid population eliminates genetic variation if we assume linkage equilibrium between alleles. To this end, we introduce the notion of frequency-independent selection at the level of alleles, which is sufficient to prove our claim and contains the notion of frequency-independent selection on haploids. When selection and recombination are weak but of the same order, there may be strong linkage disequilibrium; numerical calculations show that stable equilibria are highly unlikely. Using the example of a diallelic two-locus model, we then demonstrate that frequency-independent selection that fluctuates in time can maintain stable polymorphism if linkage disequilibrium changes its sign periodically. We put our findings in the context of results from the existing literature and point out those scenarios in which the possible role of frequency-independent selection in maintaining genetic variation remains unclear.
Turismo y fronteras: revisión de la producción académica y los aportes conceptuales desde la geografía
Authors: Porcaro Tania 
Published: August 2017

Este artículo presenta una revisión bibliográfica sobre la relación entre turismo y fronteras, -tema que ha recibido un renovado interés académico en las últimas décadas-, haciendo énfasis en aquellos trabajos elaborados desde la geografía, e identificando las principales líneas temáticas y contribuciones teóricas. Mientras que la mayoría de las publicaciones comprenden estudios de caso, un conjunto de trabajos propone algunas conceptualizaciones sobre el tema. Sin embargo, estos abordajes no siempre retoman las nuevas contribuciones teóricas producidas en los estudios sobre fronteras y turismo. De todas formas, algunas investigaciones han comenzado, en forma incipiente, a delinear propuestas innovadoras que abren líneas de estudio prometedoras para abordar la relación entre turismo y fronteras.
A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors
Authors: Leong Stephen , Moss Rebecca A. , Bowles Daniel W. , Ware Joseph A. , Zhou Jing , Spoerke Jill M. , Lackner Mark R. , Shankar Geetha , Schutzman Jennifer L. , van der Noll Ruud , Voest Emile E. , Schellens Jan H.M. 
Published: August 2017

Abstract

Background
Epidermal growth factor receptor (EGFR) and phosphatidylinositol 3-kinase (PI3K) are involved in the proliferation and survival of many cancer types. Enhanced antitumor activity may be achieved through combined inhibition of these pathways. We report results for pictilisib (GDC-0941, a class I pan-PI3K inhibitor) plus erlotinib (an EGFR tyrosine kinase inhibitor) in patients with advanced solid tumors.

Materials and Methods
A 3 + 3 dose-escalation study was carried out at a starting daily dose of 60 mg pictilisib on days 1–21 of a 28-day cycle and 150 mg erlotinib from day 2 of cycle 1. The primary objectives of the study were to assess safety and tolerability, identify dose-limiting toxicities (DLTs), estimate the maximum tolerated dose, and identify the recommended phase II dose (RP2D). Evaluation of a dose-expansion cohort at the RP2D was performed.

Results
Fifty-seven patients were treated in the study. All patients experienced at least one adverse event (AE). Grade ≥3 AEs, serious AEs, and deaths were reported in 38 (66.7%), 19 (33.3%), and 4 (7.0%) patients, respectively. DLTs occurred in nine patients across eight cohorts and the RP2D was determined to be 340 mg pictilisib on a “5 days on, 2 days off” schedule plus 100 mg erlotinib. Two patients (3.5%) experienced partial response and 19 (33.3%) had stable disease.

Conclusion
Combining pictilisib with erlotinib in patients with advanced solid tumors is feasible; however, antitumor activity is limited. Additional studies may identify patients likely to benefit from combined inhibition of EGFR and PI3K pathways.