bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tecnología y Personalización del Aprendizaje
Authors: Teran-Pazmiño Esther Marisol , Cadena-Morales Leidy Susana , González-González Lady Patricia , Guamán-Sánchez Narcisa de Jesús , León-Flores María Cleofé 
Published: September 2024

Esta investigación presenta algunas consideración y beneficios que representan el uso de la tecnología en la personalización del aprendizaje. Se parte desde una mirada a la importancia de la alfabetización digital la cual se considera fundamental para eliminar la brecha digital y mejorar el uso, implementación y adaptación de procesos pedagógicos. De igual manera partiendo desde la importancia de las tics, en la creación y manejo de herramientas digitales se identificaron tres características básicas: la gestión del aprendizaje, archivo de información y el diseño y presentación de contenidos educativos. A través de estas funciones se desarrolló la investigación e identifico los aspectos más importantes de las herramientas digitales en cada enfoque. De igual manera, se centra en determinar las argumentos de mayor relevancia respecto al uso de la IA en la personalización del aprendizaje, viendo este avance tecnológico como una oportunidad para la mejora educativa, en especial de los procesos de enseñanza y aprendizaje, así como una mirada a la importancia de la recolección y análisis de datos sobre los estudiantes. La investigación al ser de carácter teórica, implementa métodos de: análisis, síntesis, hermenéutico y sistémico. Mismos que facilitan la comprensión y entendimiento de las consideraciones más relevantes de este estudio. Los resultados obtenidos vislumbran que el uso de la tecnología, beneficia en gran medida a la personalización del aprendizaje debido a que mediante las herramientas digitales y la incorporación de la IA en la educación, es posible mejorar y atender las necesidades educativas de los alumnos debido a que los medios tecnológicos facilitan la creación, adaptación y presentación de contenidos y recursos educativos pensados en atender a los estilos de aprendizaje y las necesidades reléales del alumnado, aspectos clave de la personalización del aprendizaje.
Development of Clinical Simulation Programs and Their Importance in the Accreditation of Simulation Centers
Authors: Moreno Mieles Andrés Eugenio , Galarza López Judith , Alcívar Moreira Indira Margareth 
Published: September 2024

Introduction: The development of Clinical Simulation requires well-structured programs tailored to the demands of university-level education in the Health Sciences, as well as appropriate management and accreditation by international evaluation entities. Accredited simulation centers are essential for health sciences education, allowing students to learn safely through the repetition of activities until they are correctly executed, thereby safeguarding patient safety. Objective: Describe the guidelines and importance of a Clinical Simulation Program as support for the activities carried out by the Health Area Simulation Center of the San Gregorio de Portoviejo University (USGP), Manabí, Ecuador, under the demands of the organizations of international accreditation.Methodology: Exploratory qualitative research, based on a review of bibliographic sources from the last 10 years regarding Simulation Programs and their importance in the accreditation of Clinical Simulation Centers.Results: A solid bibliographic foundation for the development of the Clinical Simulation Program at USGP.Conclusions: USGP is engaged in sustained efforts to develop its Simulation Center and to apply Simulation-Based Education methodologies.
Laparoscopic cholecystectomy for chronic stone cholecystitis in a patient with situs inversus totalis managed at the Delfina Torres De Concha Hospital in Esmeraldas; case report
Authors: Guerrero Palma José Antonio , Mera Aguilar Danny Alberto , Chinchín Correa Wendy Estefanía , Yugsi Mera Estefani Andrea , Gary Alexi Machuca Almeida Gary Alexi , Jiménez Mejía Geovanna Nataly , Carrión Guzmán Luis Felipe , Safadi Tituaña Daniel Alexander , Fonseca Barragán José Vicente , Ruilova Blacio Juan Carlos 
Published: September 2024

Situs Inversus Totalis (SIT) is when all the organs of the body are inverted towards the opposite side. Its incidence varies between 1 in 5.000 and 1 in 20.000 people, and it is due to an autosomal recessive gene. This disorder is characterized by the mirror arrangement of the thoracic and abdominal viscera, and can lead to cardiac, intestinal and vascular complications. Although laparoscopic cholecystectomy is the standard treatment for cholelithiasis, it can present technical challenges in cases of situs inversus, especially for right-handed surgeons, and it is preferable to be performed by a left-handed surgeon, although this is not strictly essential. Although there is no evidence of a higher incidence of cholelithiasis in patients with situs inversus totalis, more variations and abnormalities are expected in these patients. This report presents the case of a female patient with SIT who underwent laparoscopic cholecystectomy, demonstrating that the procedure can be performed safely with minimal adaptations, such as in this case the variant of using an 11 mm trocar in the third port for the handling of the clipper for skilled surgeons in any health home that has the equipment and trained personnel, given the rarity of this condition, these cases provide valuable information and challenge to the conventional understanding of organ positioning
Estudio de caso del uso de la mercadotecnia digital de una empresa productora de cerveza artesanal de Morelia, Michoacán
Authors: Pacheco Serranía Carlos Cecilio , Villa Hernández Lorena Ayerim 
Published: September 2024

Actualmente existen más de 10,000 cervecerías artesanales alrededor del mundo que producen y comercializan aproximadamente más de 60,000 marcas. La cerveza artesanal percibe una preferencia que ha ido en aumento, considerada por algunos como un producto gourmet y selecto con un crecimiento en el mercado de las bebidas alcohólicas. Una de las principales formas de comercializar de este sector es mediante la mercadotecnia digital. El objetivo principal del estudio fue analizar las acciones de mercadotecnia digital que ha llevado la empresa Maltería Zurumuato, para la promoción y posicionamiento de su cerveza “La Estación”. En la investigación se utilizó una metodología con perspectiva cualitativa, exploratoria y descriptiva. Se encontraron hallazgos como una débil estrategia de mercadotecnia digital, debido a la falta de presencia y análisis de las métricas de las redes sociales, así como la falta de un especialista para el manejo de las mismas. Para favorecer su presencia, posicionamiento y adquirir una relación más cercana con sus consumidores, se recomendaron estrategias digitales en redes sociales y página web, así como la designación de un Community Manager que gestione las redes sociales y otras herramientas del marketing digital, se propone desarrollar un plan de marketing digital y su participación en actividades como ferias gastronómicas y diversos eventos culturales. Finalmente se logró identificar las áreas de oportunidad y se definieron propuestas de solución para aumentar la presencia y posicionamiento de su marca en el mercado, con lo cual podrán crecer de manera exponencial.
Comparing the efficacy of cipaglucosidase alfa plus miglustat with other enzyme replacement therapies for late-onset Pompe disease: a network meta-analysis utilizing patient-level and aggregate data
Authors: Shohet Simon , Hummel Noemi , Fu Shuai , Keyzor Ian , MacCulloch Alasdair , Johnson Neil , Castelli Jeff , Czarny-Ozga Ilona , Mozaffar Tahseen , Thom Howard 
Published: September 2024

Aim:Late-onset Pompe disease is characterized by progressive loss of muscular and respiratory function. Until recently, standard of care was enzyme replacement therapy (ERT) with alglucosidase alfa. Second-generation ERTs avalglucosidase alfa (aval) and cipaglucosidase alfa with miglustat (cipa+mig) are now available. Without head-to-head trials comparing aval with cipa+mig, an indirect treatment comparison is informative and timely for understanding potential clinical differentiation.Materials & methods:A systematic literature review was performed to identify relevant studies on cipa+mig and aval. Using patient-level and aggregate published data from randomized controlled trials (RCTs) and phase I/II and open-label extension (OLE) trials, a multi-level network meta-regression was conducted, adjusting for various baseline covariates, including previous ERT duration, to obtain relative effect estimates on 6-minute walk distance (6MWD, meters [m]) and forced vital capacity (FVC, % predicted [pp]). Analyses of two networks were conducted: Network A, including only RCTs, and network B, additionally including single-arm OLE and phase I/II studies.Results:Network B (full evidence analysis) showed that cipa+mig was associated with a relative increase in 6MWD (mean difference 28.93 m, 95% credible interval [8.26–50.11 m]; Bayesian probability 99.7%) and FVC (2.88 pp [1.07–4.71 pp]; >99.9%) compared with aval. The comparison between cipa+mig and aval became more favorable for cipa+mig with increasing previous ERT duration for both end points. Analysis of network A showed that cipa+mig was associated with a relative decrease in 6MWD (-10.02 m [-23.62 to 4.00 m]; 91.8%) and FVC (-1.45 pp [-3.01 to 0.07 pp]; 96.8%) compared with aval.Conclusion:Cipa+mig showed a favorable effect versus aval when all available evidence was used in the analysis.
Analisis Perilaku Aparat Desa dalam Meningkatkan Mutu Pelayanan Publik di Kantor Desa Momalia 1 Kecamatan Posigadan Kabupaten Bolaang Mongondow Selatan
Authors: Saputra Ariandi 
Published: September 2024

Penelitian ini bertujuan untuk Analisis Perilaku Aparat Desa dalam Meningkatkan Mutu Pelayanan Publik di Kantor Desa Momalia 1 Kecamatan Posigadan Kabupaten Bolaang Mongondow Selatan. Metode yang digunakan adalah metode penelitian kualitatif. Teknik pengumpulan data meliputi observasi dan wawancara kemudian dianalisis untuk menghasilkan temuan- temuan yang tekait denagn perilaku aparat desa dalam memberikan pelayanan. Hasil penelitian menunjukkan aparat desa dalam memberikan pelayanan publik di desa Momalia 1 Kecamatan Posigadan sudah menunjukkan kearah peningkatan mutu pelayanan publik tetapi belum berjalan maksimal. Pemberian informasi mengenai persyaratan yang harus dipenuhi warga masyarakat kurnag tersampaikan dengan baik sehingga masyarakat harus kembali kerumah utnuk melengkapi berkas. Pengetahuan dalam pelayanan oleh aparat desa masih kurang seprti adanya oknum pegawai memberikaan pelayanan lebih mendahulukan warga yang dikenalnya. kesimpulan bahwa perilaku pegawai dalam pemberian layanan di di kantor desa Momalia 1 Kecamatan Posigadan Kabupaten Bolaang Mongondow Selatan sudah menunjukkan kearah peningkatan mutu pelayanan publik, namun belum begitu maksimal. Untuk meningkatkan kualitas pelayanan publik, perlu dilakukan upaya yang komprehensif. Langkah-langkah perbaikan harus mencakup edukasi kepada masyarakat tentang sistem pelayanan publik yang ada, serta penegakan aturan dan etika yang ketat bagi petugas. Selain itu, perlu juga ditingkatkannya koordinasi antar instansi terkait untuk memastikan pelayanan yang efektif dan efisien.
Kata kunci: perilaku; pelayanan publik
Pensamento Matemático de Estudantes Superdotados Matematicamente Habilidosos: Uma experiência na perspectiva da Investigação Matemática
Authors: Lemos Jr João Carlos , Caetano Joyce 
Published: September 2024

Ao se considerar o cenário da Educação Especial, especificamente em relação aos estudantes superdotados matematicamente habilidosos, buscamos compreender estes sujeitos por meio de vertentes multidimensionais por meio do Modelo Tripartido de Alta Capacidade de Pfeiffer (2002, 2013, 2015) e o do Modelo de Identificação XIP, de Kuipers (2007, 2011, 2020) na perspectiva da metodologia da Investigação Matemática de Ponte et al. (1998, 2002, 2020). A pesquisa ambientada em uma experiência de ensino, é de abordagem qualitativa e interpretativa, com delineamento exploratório, a qual revela e discute resultados da participação de três estudantes do Ensino Fundamental – anos finais, superdotados matematicamente habilidosos, estando esses, matriculados no Núcleo de Atividades para Altas Habilidades/Superdotação do Estado do Paraná. Para a composição dos dados, consideramos como instrumentos de coleta: questionários e transcrições de aulas gravadas. Durante a análise, consideramos os preceitos da Análise de Conteúdo, segundo Bardin (2016), e inferimos que há grande potencial nesse estilo de trabalho, sendo evidenciado uma das categorias como “estilo próprio de pensamento”, a qual foi evidente durante a abordagem da Investigação Matemática.
Formal Formulations of the Line Element as it Appears in A Sample of Microscopic Shapes
Authors: Naglaa Muhammad Farouk Ahmed  , Aber Abdo Mohamed  , Afaf Ahmed Mohamed Farraj  , Ahmed Mustafa Mohamed Abdel Aziz Hassan  
Published: September 2024

Problem Background: Design is that complete process of planning and creating a form in a functionally satisfying way, bringing pleasure to the soul, and satisfying human need utilitarianly and aesthetically at the same time. The design has its elements, which is the vocabulary of the language of the form used by the designer artist, and the elements of the design line, and is considered a basic means of expression in plastic art, the researcher has noted that microscopes have a variety of formulations of design elements, limited in the current research to try to reach the formal formulations of the line element as it appears in a sample of microscopes?.
The Research Problem: The problem of the current research is summarized in the following question: What are the formal formulations of the line element as it appears in a sample of microscopic shapes?
Research Objective: Detecting the formal formulations of the calligraphy element through a sample of microscopic shapes.
Hypothesis of Research: There is a positive relationship between the type of formal formulations of the line element and the type of sample of microscopic shapes.
Research Methodology: The current research follows the descriptive approach in its form: content analysis, where the researcher describes and classifies the formal formulations of the line element, as they appear in a sample of microscopic shapes.
Research Results: The research reached a set of formal formulations of the line element through the microscopic sample used in the current research.
The Relationship between IT Integration, Organizational Culture, and Supply Chain Performance
Authors: Sahil Suri  , Nagraj Patil  , Prakhar Goyal  , Amita Garg  , Lovish Dhingra  , Mukul Pandey  , Dr. Anand Kopare  
Published: September 2024

IT integration plays an important role in boosting supply chain performance (SCP) in today’s dynamic organizational environment. It becomes easier for real-time data sharing, collaboration, and communication among supply chain participants. However, the prevailing organizational culture has a considerable impact on how effective IT integration exists, as it can either help or hinder the adoption and exploitation of IT integration. The relationship between SCP, organizational culture, and IT integration is examined in this study. Measurement model assurance and research hypothesis examination are accomplished through the use of structural equation modeling (SEM). 90 manufacturing firms are surveyed for this research online. This analysis employs regression analysis and an ANOVA test that confirms the significant correlation between IT integration, organizational culture, and SCP. The results and findings show that supply chain performance and IT integration are positively correlated, highlighting the fact that the impact of IT integration is increased by an encouraging organizational culture that values adaptability, teamwork, and continuous learning. (β=0.50,0.45,0.35,and 0.30,p<0.001) provide strong evidence in favor of hypotheses 1–4. The study finds that SCP is greatly improved by successful IT integration, but the effectiveness of the integration is heavily dependent on an organizational culture that encourages flexibility and teamwork.
Silk Fibroin-Based Scaffolds: Potential for Applications in Wound Healing
Authors: Pallavi Meshram  , Rucha Joshi  
Published: September 2024

Chronic wounds, such as diabetic foot ulcers, pose significant challenges due to their prolonged inflammation state, slow vascularization, lack of supportive matrix, and frequent recurrence. Biocompatible materials like silk fibroin (SF) and collagen can be promising in chronic wound healing applications due to their biocompatibility, and ability to act as supporting matrix necessary for tissue regeneration. This study explores the development and characterization of SF-based biomaterials in various formats, including gels, lyophilized scaffolds, and films, by combining them with collagen (Col) and heparin (Hep) molecules that are known for the wound-healing properties. SF gels, films, and lyophilized scaffolds were characterized for water retention capacity, porosity, contact angle, and antibacterial properties. Curcumin-loaded films reported moderate wetting behavior but were brittle, thin and hard. Freeze-dried scaffolds possessed higher water retention capacity compared to the sonicated gels and films, and showed a porous network structure, while the fabricated SF gels disintegrated in water. SF with a chelating agent demonstrated mild antibacterial properties, which were retained when combined with Collagen peptides and Heparin. The antimicrobial effect was significantly enhanced when SF+Col+Hep was added with antimicrobial agents such as Gentamicin and Ceftriaxone. The study concludes that SF-based scaffolds, particularly those incorporating collagen peptides and heparin, can be leveraged for molecular delivery application towards wound healing. Future research should focus on improving mechanical properties, measuring release kinetics of heparin and other biomolecules from SF-based lyophilized scaffolds, and conducting in vivo studies to validate the therapeutic value.
Regulating the Acceptance of Witnesses in Corruption Cases within the Protection Program in the Saudi Law and its Obligations
Authors: Mohammed Ali Mohammed Al-Qarni  
Published: September 2024

In light of the development of the means of corruption crimes and the diversity of their methods including the use of modern technology in these crimes, and based on the growing idea of everyone's responsibility to address this crime and their right to do so, considering that the cooperation between members of society and the relevant state institutions is one of the most important ways to confront and address this crime, and since there is a potential threat to those who address reporting or witnessing the commission of these crimes, the Saudi Arabia has issued a new law for the protection of whistleblowers, witnesses, experts and victims, issued by Royal Decree No. (M/148) dated 8/8/1445 AH, which clarifies the mechanism for protecting whistleblowers, witnesses, experts and victims, and how they are subjected to the protection program, their responsibilities, and the forms of protection provided to them.
In view of the vital role played by the witness in detecting and combating corruption crimes, and the emergence of a new law in the Kingdom that sets statutory rules for the protection of witnesses, this research aimed to answer a key question, what are the mechanisms for regulating the acceptance of witnesses in corruption cases within the protection program in the Saudi law and what are its obligations?
This will be done using the descriptive and analytical research methodology, by studying the legal regulation of the admission of the witness to the witness protection program, and his obligations.
The study reached several results, the most important of which are: the development of the Saudi regulation in corruption cases and the application of the necessary guarantees to ensure the protection of human rights, and highlighting the methods of its inclusion within the witness protection program in corruption cases and the limits of the witness's obligations, in the event when requesting for protection is approved.
A Survey Study on the Influencing Factors of Life Satisfaction of Chinese Elders in New Zealand in the Internet Era
Authors: Jiang Jax Zhaoze 
Published: September 2024

This thesis investigates the factors influencing the life satisfaction of elderly Chinese immigrants in New Zealand in the era of increasing internet usage. With a significant population of over 40,000 Chinese elders aged 65 and above residing in New Zealand, the study focuses on how the internet affects their social integration, access to information, and overall well-being. The research primarily utilizes a survey methodology, distributing questionnaires among various Chinese community organizations to collect data on internet usage patterns, social behaviors, and perceived life satisfaction. The findings suggest that internet use plays a crucial role in enhancing life satisfaction by providing means of social connectivity, access to daily information, and maintaining cultural ties. The study concludes that the effective use of the internet correlates with higher life satisfaction among Chinese seniors in New Zealand. Education level, physical health, and income emerged as significant factors affecting life satisfaction as well. The thesis advocates for enhanced digital literacy programs and health care services tailored to the needs of elderly immigrants, promoting a more inclusive approach to community support and engagement.