bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of elevated direct factor Xa inhibitor plasma levels on perioperative blood loss in patients undergoing urgent surgery
Authors: Mair Alexander , Sahli Sebastian D. , Studt Jan‐Dirk , Braun Julia , Lunkiewicz Justyna , Spahn Donat R. , Kaserer Alexander 
Published: September 2024

AbstractIntroductionData on the perioperative bleeding risk associated with elevated plasma levels of direct factor Xa inhibitors (FXa inhibitors) are limited. This study examines perioperative red blood cell (RBC) loss in patients undergoing urgent surgery with a residual FXa inhibitor level exceeding 100 mcg/L and without preoperative FXa inhibitor reversal.MethodsThis retrospective analysis includes data from 32 patients who underwent urgent noncardiac surgery between 2018 and 2022. This study aims to analyze perioperative RBC loss in patients undergoing urgent surgery with a residual FXa inhibitor level exceeding 100 mcg/L and without preoperative FXa inhibitor antidote‐based reversal or unspecific treatment with 4‐factor prothrombin complex concentrate (PCC). All patients were managed using a watch‐and‐wait strategy.ResultsThe last determination of FXa inhibitor plasma concentration prior to surgery showed a median of 245 mcg/L (IQR 144–345), with a median time interval of 3.8 h (IQR 2.4–7.2) before incision. Median RBC loss during surgery was 49 mL (IQR 0–253), 189 mL (IQR 104–217) until POD1 and 254 mL (IQR 58–265) until POD3. Only one patient required intraoperative treatment with 4‐factor‐PCC and none required reversal with andexanet alfa. Linear regression models found no significant influence of FXa inhibitor plasma levels on intraoperative RBC loss. Rivaroxaban was associated with higher RBC loss until postoperative Day 1 compared with apixaban. No thromboembolic events were observed.ConclusionDespite markedly elevated plasma concentrations of residual direct FXa inhibitors, perioperative RBC loss was limited in patients undergoing urgent noncardiac surgery. The intraoperative watch‐and‐wait strategy with selective intraoperative FXa inhibitor reversal or treatment only when required appears to be an appropriate approach.
Skin metabolism in obesity: A narrative review
Authors: Zaccaron Rubya Pereira , Mendes Carolini , da Costa Camila , Silveira Paulo Cesar Lock , Rezin Gislaine Tezza 
Published: September 2024

AbstractObesity is a complex multifactorial disease in which excess body fat triggers negative health effects. Systemically, obesity causes several changes, such as inflammation, oxidative stress, mitochondrial dysfunction and apoptosis; factors linked to the slow and incomplete epithelial regenerative process. Specifically, in the integumentary system, obesity causes an expansion of the skin's surface area and changes in collagen deposition. Molecular underpinnings of why obesity delays wound healing are still poorly understood. In addition to the primary role of dermal adipocytes in lipid storage and heat insulation, they also promote skin immunity, wound healing and hair follicle cycling. As a consequence of the cellular and dysfunctional adaptations of adipocytes, inflammatory immune alterations, alteration in the expression of proteins genes associated with the blood supply, altered collagen formation through fibroblast senescence and excessive degradation of extracellular matrix proteins are metabolic characteristics of the system in obesity that contribute to sustained inflammation and decreased mechanical resistance of the skin.
Curves are algebraic K(π,1)$K(\pi,1)$: Theoretical and practical aspects
Authors: Levrat Christophe 
Published: September 2024

AbstractWe prove that any geometrically connected curve over a field is an algebraic , as soon as its geometric irreducible components have nonzero genus. This means that the cohomology of any locally constant constructible étale sheaf of ‐modules, with invertible in , is canonically isomorphic to the cohomology of its corresponding ‐module. To this end, we explicitly construct some Galois coverings of corresponding to Galois coverings of the normalisation of its irreducible components. When is finite or algebraically closed, we precisely describe finite quotients of that allow to compute the cohomology groups of the sheaf, and give explicit descriptions of the cup products and in étale cohomology in terms of finite group cohomology.
Neuro-Cognitive Insights Into Engineering Design: Exploring Electroencephalography Predictive Associations With Task Performance
Authors: Li Shumin , Becattini Niccolò , Cascini Gaetano 
Published: September 2024

Abstract
This paper investigates the relationship between brain activity, measured by electroencephalography (EEG) data, and the performance assessment result of engineering design activities involving different cognitive processes. Employing a novel signal processing pipeline, we analyzed EEG variations of 37 subjects during two design tasks that mostly leverage, respectively, convergent and divergent thinking: the design with morphological table (task and the problem-solving task. The EEG recordings underwent meticulous artifact removal, allowing for a comprehensive investigation into the statistical relationships between frequency bands, channels, and design outcome performance metrics. The developed models linking better design outcomes with brain (de)synchronization demonstrated remarkable accuracy, precision, and recall across performance metrics for both tasks. Notably, the EEG data in theta band measured from the frontal area at both hemispheres and a left parietal/occipital channel were essential for estimating better design performance with brain desynchronization. On the contrary, the model based on brain synchronization produces precise estimations of design performance with alpha band and channels in temporal and parietal areas. These findings highlight EEG variation as a viable proxy for design performance, paving the way for more effective performance prediction models with fewer sensors. Overall, this research contributes to the emerging field of neurocognitive design assessment and underscores the potential for EEG-based predictions in engineering design tasks.
Who Does Design Research Serve? A Critical Evaluation of the Diversity of Samples Studied in Design Theory and Methods Research
Authors: Johnson Erin , Toh Christine , Menold Jessica 
Published: September 2024

Abstract
Human subjects are often used in design theory and methods studies to understand how designers behave and link behaviors with design outcomes. We highlight that much of our past work and resultant knowledge in design theory and methodology (DTM) has used data from samples composed mainly of White men. We argue, therefore, that the tools, methods, and practices conceived through research intended for universal use may not be as generalizable as intended. We support this assertion through a quantitative assessment of past DTM literature. We definitively demonstrate a historic lack of diversity in human-subjects research in DTM through a critical review of 109 published works. Our findings suggest that age, gender, and race/ethnic background are underreported. This work is a call to action for researchers to reflect on who are the beneficiaries of design theory and methods research, how participant background might impact the findings, and what strategies can be employed to fulfill our promise of a more equitable design community and impact.
Exploring the Manifestation of Design for Manufacturing Heuristics in Students' Early-Stage Engineering Design Concepts
Authors: Pearl Seth , Meisel Nicholas A. 
Published: September 2024

Abstract
Additive manufacturing (AM) can produce designs in a manner that greatly differs from the methods used in the older, more familiar technologies of traditional manufacturing (TM). As an example, AM's layer-by-layer approach to manufacturing designs can lead to the production of intricate geometries and make use of multiple materials, made possible without added manufacturing cost and time due to AM's “free complexity.” Despite this contrasting method for manufacturing designs, designers often forgo the new design considerations for AM (AM design heuristics). Instead, they rely on their familiarity with the design considerations for TM (TM design heuristics) regardless of the intended manufacturing process. For designs that are intended to be manufactured using AM, this usage of TM design considerations is wasteful as it leads to unnecessary material usage, increased manufacturing time, and can result in designs that are poorly manufactured. To remedy this problem, there is a need to intervene early in the design process to help address any concerns regarding the use of AM design heuristics. This work aims to address this opportunity through a preliminary exploration of the design heuristics that students naturally leverage when creating designs in the context of TM and AM. In this study, 117 students in an upper-level engineering design course were given an open-ended design challenge and later tasked with self-evaluating their designs for their manufacturability with TM and AM. This evaluation of the students' designs was later repeated by relevant experts, who would identify the common design heuristics that students are most likely to use in their designs. Future studies will build on these findings by cementing early-stage design support tools that emphasize the significant heuristics found herein. For example, this work found that the design heuristic “incorporating complexity” was the most significant indicator of designs most suited for AM and should therefore be highly encouraged/emphasized when guiding designers in the use of AM. In doing so, it will be possible for early-stage design support tools to maximally improve designs that are intended to be manufactured for AM.
Micro-Channel Cooling of Hot Spots Through Nonuniform Aspect Ratio Designs
Authors: McCreary Chase A. , Solovitz Stephen A. 
Published: September 2024

Abstract
Electronic devices experience spatial variation in power dissipation, which results in high-temperature hot spots. These locations require aggressive thermal management, which can be complex and costly. Simple solutions such as single-phase microchannels can provide adequate heat transfer, but they are not designed to control heat transfer locally. However, microchannels can be tailored to control local flowrates and heat transfer, potentially mitigating hot spot temperatures. Using a conductive and convective resistance network for a micro-channel, an analytical model is generated for heat transfer within an individual passage. For a given channel width, this model relates the channel depth to its resistance through a power law. Over a wide range of heat fluxes, the optimal design balances local temperatures to within 3 K. The analytical model is validated using computational simulations of the optimized heat sink. For a randomly generated, nonuniform power distribution, device temperatures are balanced with a sample standard deviation below 2.5%, which is significantly better than a baseline design. When heat spreading is incorporated, the temperature increase is smaller but remains uniform, indicating that the hot spots can be mitigated.
Throwing Them Under the Bus: The Framing of a Critical Incident at the Tour de France
Authors: Snelgrove Ryan , Wood Laura , Hoeber Larena , Hoeber Orland 
Published: September 2024

In the context of sport events, several stakeholders’ reputations could be impacted by critical incidents, including event organizers, athletes, teams, countries represented by athletes, and sponsors. The purposes of this study were to develop an understanding of (a) how an event organizer, media, and the public framed a critical incident in a rhetorical arena and (b) how frames were connected with the reputations of event stakeholders immediately following a critical incident. A three-phase approach was employed that involved collecting and analyzing data from X/Twitter about a bus crash at the 2013 Tour de France. The critical incident was framed in nine different ways, many of which were emergent. Findings demonstrated that critical incidents at a sport event are interpreted and framed in multiple ways and can have an impact on the reputations of the event and other event stakeholders.
Strategic Analysis of Net Exchanges in Professional Padel: Insights From Different Competition Phases of the World Padel Tour Finland Padel Open Tournament
Authors: Escudero-Tena Adrián , Conde-Ripoll Rafael , Lupo Corrado , Ungureanu Alexandru Nicolae 
Published: September 2024

Purpose: This study analyzed the effectiveness of net exchanges (ie, number of times the pairs exchange their zone on the court from the net zone to the back zone or vice versa) in men’s and women’s professional padel depending on the competition phase. Methods: Data were collected from 41 matches, comprising a total of 4829 points, from both the qualifying and the main draws of the World Padel Tour Finland Padel Open tournament. Descriptive analysis (frequency and percentage) and inferential tests (Pearson chi-square [χ2], Cramer V coefficient [Vc], corrected standardized residuals, and chi-squared automatic interaction detection) were carried out. Results: There were significant differences (P < .05) in net exchanges between the main and qualifying draws, both in men’s (79.6% vs 72.1% for no exchanges) and women’s (62.2% vs 57.6% for no exchanges) padel. Additionally, differences in the likelihood of winning points based on whether the serving pair or the returning pair finished the rally at the net were highlighted. Indeed, finishing rallies at the net for the serving pairs increased the probability of scoring a winning shot (ie, in even-numbered net exchanges), while finishing rallies away from the net (ie, in odd-numbered net exchanges) was more likely to result in errors, for both male and female players and main and qualifying draws. Conclusion: This study provides valuable insights into the strategic behavior of professional padel matches, highlighting the importance of net dominance and its impact on match outcomes, particularly in relation to gender differences and phase of competition.
Implementation Evaluation of a Parks- and Faith-Based Multilevel Intervention to Promote Physical Activity Among Latinos
Authors: Perez Lilian G. , Blagg Tara , Celeste-Villalvir Alane , Castro Gabriela , Mata Michael A. , Perez Sergio , Arredondo Elva , Loy Steven , Larson Anne , Derose Kathryn P. 
Published: September 2024

Background: Latinos in the United States face multiple barriers to engaging in physical activity (PA). We implemented a faith-based multilevel intervention to promote PA in parks for Latino adults, which was partially adapted to a virtual platform during the COVID-19 pandemic, and evaluated it using the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework. Methods: We conducted in-depth semistructured interviews (83% in Spanish) with 24 intervention participants (75% women) participating in a cluster randomized controlled trial in 2019–2022 that linked 6 churches (3 intervention, 3 control) with parks in East Los Angeles, CA. The intervention included in-person, park-based fitness classes, which were adapted to Facebook during the pandemic; PA motivational text messages; and other activities. Interviews assessed Reach (participation), Effectiveness (perceived impacts), Implementation (participation barriers/facilitators), and Maintenance (plans for sustaining PA), as well as perceived pandemic impacts. Results: About 80% of interviewees participated in ≥1 park class and 67% in ≥1 virtual class (Reach). Interviewees perceived positive intervention impacts across multiple health and well-being domains (Effectiveness) despite perceived negative pandemic impacts; several facilitators to participation (personal, social, program) and few barriers (personal, virtual, environmental; Implementation); and plans for maintaining PA (eg, revisiting intervention text messages and video recordings; Maintenance). Conclusions: Findings support the utility of Reach, Effectiveness, Adoption, Implementation, and Maintenance to understand the broad impacts of a faith-based PA intervention. Findings point to the adaptability and robustness of the intervention during a public health crisis. Overall, findings may help inform the translation of the intervention to other communities to advance health equity.
Motor Point as an Alternative to Femoral Nerve Stimulation for the Assessment of Quadriceps Muscle Inhibition in Healthy Women
Authors: Pompeo Klauber D. , Rabello Rodrigo , Morales Anete B. , Klein Kelli D. , Frasson Viviane B. , Maffiuletti Nicola A. , Vaz Marco A. 
Published: September 2024

Context: The evaluation of quadriceps muscle inhibition with the interpolated twitch technique is usually performed by stimulating the femoral nerve (FN). However, there are some problems related to the use of this stimulation site, which may be partially overcome by delivering the stimulation over the motor point (MP). This study sought to compare MP to FN stimulation at different joint angles for the evaluation of quadriceps muscle inhibition, resting peak torque, and discomfort in healthy women. Design: Cross-sectional study. Methods: Sixteen healthy women (age: 28 [4] y; body mass: 60 [5] kg; height: 162 [5] cm) participated in this study. Supramaximal paired stimuli were delivered to the FN and to the rectus femoris MP before and during maximal voluntary contractions at different knee angles (15°, 30°, 45°, 60°, and 90° of knee flexion) to assess muscle inhibition and resting peak torque. Discomfort was also recorded for each stimulation site and knee angle. Results: Muscle inhibition was similar between the 2 stimulation sites (P > .05) and was higher at 45° than at 90° (P = .03). MP stimulation evoked lower resting peak torque at 30° (P = .004), 60° (P = .006), and 90° (P = .006) and higher discomfort at 30° (P = .008) and 90° (P = .027) compared to FN stimulation. Conclusions: Despite lower resting peak torque and higher discomfort at some angles, MP stimulation provided similar muscle inhibition to FN stimulation at all knee angles and is therefore a valid method to evaluate quadriceps muscle inhibition in healthy women. MP stimulation can be used as an alternative to FN stimulation for the evaluation of quadriceps muscle inhibition with no added discomfort at the angles where muscle inhibition is the highest.
The energy metabolism of
Cupriavidus necator
in different trophic conditions
Authors: Jahn Michael , Crang Nick , Gynnå Arvid H. , Kabova Deria , Frielingsdorf Stefan , Lenz Oliver , Charpentier Emmanuelle , Hudson Elton P. 
Published: September 2024

ABSTRACT

The “knallgas” bacterium
Cupriavidus necator
is attracting interest due to its extremely versatile metabolism.
C. necator
can use hydrogen or formic acid as an energy source, fixes CO
2
via
the Calvin-Benson-Bassham (CBB) cycle, and grows on organic acids and sugars. Its tripartite genome is notable for its size and duplications of key genes (CBB cycle, hydrogenases, and nitrate reductases). Little is known about which of these isoenzymes and their cofactors are actually utilized for growth on different substrates. Here, we investigated the energy metabolism of
C. necator
H16 by growing a barcoded transposon knockout library on succinate, fructose, hydrogen (H
2
/CO
2
), and formic acid. The fitness contribution of each gene was determined from enrichment or depletion of the corresponding mutants. Fitness analysis revealed that (i) some, but not all, molybdenum cofactor biosynthesis genes were essential for growth on formate and nitrate respiration. (ii) Soluble formate dehydrogenase (FDH) was the dominant enzyme for formate oxidation, not membrane-bound FDH. (iii) For hydrogenases, both soluble and membrane-bound enzymes were utilized for lithoautotrophic growth. (iv) Of the six terminal respiratory complexes in
C. necator
H16, only some are utilized, and utilization depends on the energy source. (v) Deletion of hydrogenase-related genes boosted heterotrophic growth, and we show that the relief from associated protein cost is responsible for this phenomenon. This study evaluates the contribution of each of
C. necator
’s genes to fitness in biotechnologically relevant growth regimes. Our results illustrate the genomic redundancy of this generalist bacterium and inspire future engineering strategies.

IMPORTANCE

The soil bacterium
Cupriavidus necator
can grow on gas mixtures of CO
2
, H
2
, and O
2
. It also consumes formic acid as carbon and energy source and various other substrates. This metabolic flexibility comes at a price, for example, a comparatively large genome (6.6 Mb) and a significant background expression of lowly utilized genes. In this study, we mutated every non-essential gene in
C. necator
using barcoded transposons in order to determine their effect on fitness. We grew the mutant library in various trophic conditions including hydrogen and formate as the sole energy source. Fitness analysis revealed which of the various energy-generating iso-enzymes are actually utilized in which condition. For example, only a few of the six terminal respiratory complexes are used, and utilization depends on the substrate. We also show that the protein cost for the various lowly utilized enzymes represents a significant growth disadvantage in specific conditions, offering a route to rational engineering of the genome. All fitness data are available in an interactive app at
https://m-jahn.shinyapps.io/ShinyLib/
.
The American Society for Microbiology collaboration with the CDC Laboratory Medicine Best Practices initiative for evidence-based laboratory medicine
Authors: Weissfeld Alice S. , Baselski Vickie , Cornish Nancy E. , Kraft Colleen S. , LaRocco Mark T. , McNult Peggy , Nachamkin Irving , Parrott James Scott , Richter Sandra S. , Rubinstein Matthew , Saubolle Michael A. , Sautter Robert L. , Snyder James W. , Taliano Joanna , Wolk Donna M. 
Published: September 2024

SUMMARY
Clinical medicine has embraced the use of evidence for patient treatment decisions; however, the evaluation strategy for evidence in laboratory medicine practices has lagged. It was not until the end of the 20th century that the Institute of Medicine (IOM), now the National Academy of Medicine, and the Centers for Disease Control and Prevention, Division of Laboratory Systems (CDC DLS), focused on laboratory tests and how testing processes can be designed to benefit patient care. In collaboration with CDC DLS, the American Society for Microbiology (ASM) used an evidence review method developed by the CDC DLS to develop a program for creating laboratory testing guidelines and practices. The CDC DLS method is called the Laboratory Medicine Best Practices (LMBP) initiative and uses the A-6 cycle method. Adaptations made by ASM are called Evidence-based Laboratory Medicine Practice Guidelines (EBLMPG). This review details how the ASM Systematic Review (SR) Processes were developed and executed collaboratively with CDC’s DLS. The review also describes the ASM transition from LMBP to the organization’s current EBLMPG, maintaining a commitment to working with agencies in the U.S. Department of Health and Human Services and other partners to ensure that EBLMPG evidence is readily understood and consistently used.