bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ubiquitination of IL-6 by FBXO7 mitigates osteoarthritis through JAK1/STAT3 pathway modulation
Authors: Huang ZhuSong , Guo Huiling , Lin XuChao , Lan JinFu , Zhao WenHan , Chen Min 
Published: October 2024

Abstract

Osteoarthritis (OA) is a chronic degenerative disease marked by cartilage destruction and subchondral bone remodeling which results in functional disability and pain. FBXO7 has been implicated in various inflammatory conditions, however, very little research has been done to establish its functional and molecular participation in the development and progression of OA. Here we show that the downregulation of FBXO7 may cause the progression and severity of OA. Articular cartilage obtained from OA patients and cartilage excised from DMM-induced OA from mice showed that FBXO7 was downregulated when compared to the controls. Mechanistically, we determined that FBXO7 interacts with the JAK1/STAT3 signaling pathway through IL-6. Immunoprecipitation assay revealed high-affinity physical interactions between FBXO7 and IL-6. When FBXO7 is downregulated in OA, the expression levels of IL-6 are elevated, which increases the activation of the JAK1/STAT3 signaling pathway. This process results in the elevation of MMP13 and suppression of type II collagen, two components crucial in the maintenance of articular cartilage homeostasis. However, overexpression of FBXO7 alleviated cartilage degradation by mediating the ubiquitination of IL-6 and degrading it, which led to the elevated expression of type II collagen, and reversed progression of OA. Therefore, targeting FBXO7 in the treatment of OA presents a promising avenue of therapy.
Fetal Subdural Hematoma –? Aspirin induced or Idiopathic – A case report
Authors: Thakur Shruti , Thakur Charu Smita , Sharma Abhinash , Makhaik Sushma 
Published: October 2024

Abstract

Background
Fetal intracranial haemorrhage (ICH) is a rare antenatal complication that increases perinatal morbidity and mortality and may cause neurodevelopmental delay in surviving babies. Even though the majority of cases are idiopathic, there are many maternal and fetal factors predisposing to ICH. Low dose aspirin has a proven efficacy in secondary preeclampsia, however, with a daily dosage of > 100mg, its safety is not well established and sporadic cases of fetal hemorrhagic complications have been reported. As fetal ICH has prognostic implications for the current and potentially for future pregnancies, in utero diagnosis is of utmost importance.
Case Presentation
A 34- year- old primigravida was diagnosed with fetal subdural hematoma (SDH) on her routine third trimester ultrasound (USG). There were no predisposing factors except that the patient was on low dose aspirin from 12th week of gestation. On serial USG, the SDH reduced in size. She delivered a healthy baby who was followed till 6 months of age and showed normal neurodevelopment.
Conclusions
As the number of reported cases of fetal ICH are limited with even rarer SDH, meaningful etiological and prognostic criteria cannot be inferred and parental counseling is challenging.
The Effects of Concomitant Application of TENS and NMES on Chronic Stroke Patients: A Prospective Randomized Controlled Study
Authors: Başar Betül , Alp Ömer Faruk 
Published: October 2024

Abstract

Background: The aim of our study was to compare the effects of TENS, NMES, and their combined application on posture, functional independence, and spasticity in patients with post-stroke hemiparesis.
Methods: Sixty patients (twenty-six female and thirty-four male), with a mean age of 61.1 years (range, 27 – 81 years) were included in our study. Patients were randomly assigned to one of four treatment groups: TENS, NMES, TENS+NMES, and isolated exercise program. The patients' posture, functional independence, and ankle plantar flexor spasticity were evaluated after 1 month of treatment and at the 4-month follow-up.
Results: Concomitant application of TENS and NMES was more successful in improving posture, functional independence and reducing spasticity at 1 and 4 months follow-up than either application alone. The application of TENS or NMES together with the exercise program provided better results in terms of posture and functional independence at the 1st month. However, it did not achieve a significant difference compared to the exercise program at the 4th month. An exercise program alone was insufficient for reducing spasticity of the ankle plantar flexors. While an additional physical therapy modality (TENS or NMES) was effective in reducing spasticity in the early period, this effect disappeared at the 4th month follow-up and similar results were achieved with an isolated exercise program.
Conclusion: Although TENS or NMES combined with exercise programs achieves successful results immediately after the treatment, it is insufficient after a few months in chronic stroke patients. In concomitant application of TENS and NMES, better results are achieved both after treatment and in a few months of follow-up. Therefore, TENS and NMES should be applied concomitantly.
What is the role of early years childcare staff in promoting and discussing children's oral health behaviours? An investigation of parent’s views
Authors: Alshammari Dalil , Coupe Nia , Peters Sarah , Goldthorpe Joanna 
Published: October 2024

Abstract

Baackground:
The primary reason children in the UK are referred to hospitals for general anaesthetic is to have their teeth removed due to tooth decay. Tooth decay is a non-communicable disease which can be prevented through healthy behaviours such as brushing at least twice a day with fluoride toothpaste, reducing the frequency of sugar consumption throughout the day and regular dental check-ups. Recently, oral health became a mandatory component of the England Early Years Settings' (EYS) framework. Successful implementation of this public health strategy necessitates involvement from parents and carers, however their views currently remain unexplored. Therefore, we aim to investigate parents' views about the role of EYS and childcare providers in promoting and discussing children’s oral health behaviours.
Method:
Semi-structured interviews were conducted in English and Arabic with 14 parents (11 mothers, 3 fathers) with at least one child under five years enrolled in any EYS (nurseries, preschools, Sure Start centres) in England. Participants were recruited through EYS settings and using online social media. Data were analysed using an inductive and latent thematic analysis.
Results:
The analysis was organized into three overarching themes: 1) Parental knowledge limited by indirect communication with staff, 2) EYS suitable to support oral health but .... and 3) EYS as a partner to support children’s oral health
Conclusion
Parents have limited awareness of oral health activities in EYS. They acknowledge that EYS staff can influence children's oral health behaviours, yet also report communication barriers with EYS staff. Early years communication is primarily uni-directional, which shapes parents' views about EYS staff's responsibility and credibility to support their children’s oral health. To overcome these barriers, staff need training and support to effectively engage parents.
Radiation Dose and Effective Risk Assessments in Adult Patient from a Common Radiological Procedure: A Comparative Study
Authors: Adeyemi Fredrick O. 
Published: October 2024

Abstract

Background: Generally, quantifying radiation risks associated with diagnostic radiology has been a subject of interest with the increased use of X-rays. So, pelvis radiography is used as a focus for dose monitoring with the need to balance the risks and benefits of a new diagnostic modality.
Objectives: This study assessed radiation dose and the risks at exposure age from pelvis examination.
Patients and methods: The study used an indirect dosimetric approach and PCXMC software to determine ESD, effective dose (ED), and the equivalent dose to organs and then calculate risk based on the average percentage increase in LAR of cancer incidence.
Results: Pelvis lateral (LAT) with averagely low ED (0.051mSv) recorded a lifetime risk coefficient (RT) (2.693E-1 Sv-1) and high effective risk (ER) (7.764E-4) against pelvis AP with ED (0.226 mSv), RT (5.90E-2 Sv-1) and low ER (9.789E-5) in a single exposure for pelvis radiograph. Generally, among organs exposed during examinations, lungs with averagely low dose recorded moderately high Ro and ER,O while pelvis bone recorded low ER,O for pelvis radiography. The urinary bladder with high doses recorded low Ro (0.011Gy-1) and ER,O (0.4985E-6). Prostate and pelvis bone recorded high and low ER,O (males), and uterus and pelvis bone (females) for pelvis AP, while these were pancreas and pelvis bone (males) and colon and pelvis (females) for pelvis LAT.
Conclusion: Studies show that adult patients within the age group (40-49 yrs.) for pelvis radiography and their organs are averagely exposed to low and minimal risks of cancer induction, respectively.
A New Variation in the Branching of the Axillary Artery: A Case Report with Surgical Implication
Authors: Suassuna Gabriel Vitório Araújo , Midena Clara Medeiros , Bandeira Wigínio Gabriel Lira , Montello Mauro Bezerra , Abreu Bento João da Graça Azevedo , Cavalcante Judney Cley 
Published: October 2024

Abstract

The axillary artery, situated amid the cords of the brachial plexus, provides branches supplying the shoulder and scapula. It then continues as the brachial artery, typically located posteromedial to the median nerve, which furnishes branches to the arm and elbow. Variations in these branches are not uncommon. However, a dissection of a fixed right upper limb at the Human Anatomy Laboratory of the Federal University of Rio Grande do Norte revealed a remarkable anatomical variation. The researchers discovered an axillary artery that bifurcates into a superficial brachial artery and a posterior trunk. The superficial brachial artery passes over the lateral root of the median nerve and runs superficially to it without giving off any branches. The posterior trunk gives rise to all the branches normally originating from the third part of the axillary artery and the brachial artery, including the subscapular artery, the humeral circumflex arteries, the deep brachial artery, and the collateral ulnar arteries. This unique vascular arrangement has not been previously described in the literature. Awareness of these variations may prevent diagnostic errors, such as misidentifying the superficial brachial artery as a vein, and may influence surgical planning and interventional procedures in the axillary region, including breast cancer surgery or axillary cavity exploration.
Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study
Authors: Xu Wei-Na , Ai Ling , Zhang Xiao-Yan , Wang Jian-Guo , Huang Yi-Min 
Published: October 2024

Abstract

Background
This study aimed to analyze the correlation factors of spontaneous preterm birth in twin pregnancies and construct a predictive model, with the hope of providing clinical value for the prediction of spontaneous preterm delivery in twin pregnancies.
Methods
A total of 218 pregnant women with twin pregnancies at Jiaxing Women and Children's Hospital, Wenzhou Medical University between June 2021 and May 2024 were enrolled. One-way Analysis of Variance (One-way ANOVA) and multivariate logistic regression analysis were used to analyze the correlation factors, and a prediction model was constructed. The nomogram model was established using R, and evaluated by the area under the ROC curve, C-index, and decision curve analysis (DCA).
Results
One-way ANOVA showed that body mass index (BMI), length of cervical canal in the second trimester, presence or absence of cervical funnel, vaginitis during pregnancy, gestational diabetes mellitus (GDM) and intrauterine hemoglobin levels were associated with spontaneous preterm birth in twin pregnancies (P < 0.05). Multivariable logistic regression analysis showed that BMI, cervical length in the second trimester and gestational vaginitis are independent correlation factors for spontaneous preterm birth in twin pregnancies. After validation, the AUC value of the combined prediction of 3 correlation factors was the largest (0.852). Overall, a nomogram model with C-index of 0.838 was successfully constructed for predicting preterm birth in twin pregnancies.
Conclusion
BMI combined with cervical canal length in the second trimester and gestation vaginitis can improve the predictive value for the delivery outcome of spontaneous preterm birth in twin pregnancies.
Genetically-encoded markers for confocal visualization of single
dense core vesicles
Authors: Griffith Leslie , Chen Nannan , Yu Junwei , Zhang Yunpeng , Clements Kelsey 
Published: October 2024

Abstract

Neuronal dense core vesicles (DCVs) store and release a diverse array of neuromodulators, trophic factors and bioamines. The analysis of single DCVs has largely been possible only using electron microscopy, which makes understanding cargo segregation and DCV heterogeneity difficult. To address these limitations, we developed genetically-encoded markers for DCVs that can be used in combination with standard immunohistochemistry and expansion microscopy, to enable single-vesicle resolution with confocal microscopy.
Exploring the therapeutic potential of Rutin and Morin in Type 2 Diabetes: A transcriptomics and molecular dynamics simulation for proteins
Authors: Kerry Rout George , Naik Hemangini , Mahapatra Soumya Ranjan , Nayak Sanghamitra , Behera Abhishek , Pattanaik Kali Prasad , Ranjan Saumya , Misra Namrata , Rout Jyoti Ranjan , Das Gitishree , Patra Jayanta Kumar , Majhi Sanatan 
Published: October 2024

Abstract

Type 2 diabetes (T2D) is a chronic, multifactorial disorder characterized by hyperglycemia or hyporinsulinemia. Despite numerous previous studies, its prevalence and associated complications continue to pose a significant global health concern. This study primarily focuses on identifying and investigating potential biomarkers and underlying molecular mechanisms that substantially impact T2D progression. A human microarray dataset (GSE20966 & GSE41762) exclusively containing pancreatic beta cells was sourced from the GEO database to facilitate the following research. The analysis of differentially expressed genes (DEGs) and the construction of co-expression networks were carried out using R and Bioconductor packages. The differentially co-expressed genes were further utilized to analyse hub genes and comprehensively characterize their functional importance by STRING, DAVID and ClueGo. The analysis conducted in this study emphasises the significance of seven hub genes (CEL, CPA1, CPB1, CTRB2, CEL3B, PLA2G1B, and REG1A) primarily implicated in T2D-associated molecular pathways such as pancreatic secretion, protein digestion and absorption and fat digestion and absorption. Among seven hub markers, direct scientific evidence underscores the role of PLA2G1B as a causative factor in the development of T2D. Therefore, further MD simulation for proteins study was conducted to comprehend the possible inhibition of the gene thereby reducing the severity of T2D. The study includes molecular docking and MD Simulation where it was established that phytocompounds (Rutin and Morin) for an instant posses higher binding affinity towards PLA2G1B in comparison to the standard inhibitors n-(p-Amylcinnamoyl) anthranilic acid. Thus, overall, it can be predicted that the flavonoids RU and MO could target PLA2G1B and might serve as a focused therapeutic approach for treating patients with T2D.
Correlations Between Metformin and Prognosis and Adverse Reactions in Patients Undergoing Radical Cystectomy Followed by Adjuvant GC Chemotherapy for Bladder Cancer
Authors: Zhang Lei , Cao Jingyi , Han Chong , Zhang Jingwen , Liu Yiwen , Li Hailong 
Published: October 2024

Abstract

Objective
The objective of this research was to examine the influence of metformin on both prognosis and adverse reactions in patients who have undergone radical cystectomy (RC) and subsequently received adjuvant gemcitabine and cisplatin (GC) chemotherapy for muscle-invasive bladder cancer (MIBC).
Methods
A retrospective evaluation was performed on data from 243 patients who had undergone RC followed by adjuvant GC chemotherapy at the Affiliated Hospital of Xuzhou Medical University, Xuzhou First People’s Hospital, and Xuzhou Third People’s Hospital during the period from April 2014 to April 2024. The subjects were categorized into three categories based on metformin usage: non-diabetic (No DM), type 2 diabetic with metformin use (DM, Metformin), and type 2 diabetic without metformin use (DM, no Metformin). Clinical and pathological characteristics were compiled and subjected to analysis. Progression-free survival (PFS) was assessed utilizing the Kaplan-Meier technique, while Cox proportional hazards models were employed for multivariable analysis.
Results
Among the 243 patients, diabetes was present in 68 individuals, of whom 51 were administered metformin. When compared to the non-diabetic cohort, diabetic patients who received metformin exhibited significantly elevated PFS rates at 1, 2, and 3 years (p = 0.024). Both univariate and multivariate analyses indicated that the utilization of metformin correlated with a reduced risk of disease progression (hazard ratio = 0.66, 95% confidence interval 0.45–0.96, p = 0.031). Moreover, those administered metformin experienced a significantly lower frequency of grade 3 or higher adverse reactions during chemotherapy in contrast to those who did not receive metformin (p = 0.011).
Conclusion
The administration of metformin is strongly correlated with enhanced prognosis and a reduction in adverse reactions in patients who have undergone RC, followed by adjuvant GC chemotherapy for MIBC. This research offers robust clinical evidence supporting the application of metformin as an adjuvant therapy in MIBC and establishes a basis for future investigations into the mechanisms by which metformin exerts its effects in cancer treatment.
Correlation and Dissociation Factors between Ionized, Total, and Corrected Calcium in Patients Undergoing Hemodialysis
Authors: Aizawa Chiharu , Nakashima Akio , Kato Kazuhiko , Kobayashi Arisa , Kawai Rena , Shibata Yuriko , Tanimoto Saya , Keita Kimura , Ohkido Ichiro , Yokoo Takashi 
Published: October 2024

Abstract

Ionized calcium (iCa) is physiologically active but cannot be directly measured easily. Although total serum calcium (tCa) and corrected calcium (cCa) using the Payne correction formula have been utilized to assess calcium levels, their limitations have been pointed out. This study aimed to clarify the degree of correlation and dissociation among iCa, tCa, and cCa levels in patients undergoing hemodialysis. A cross-sectional study assessed the correlation between iCa, tCa, and cCa levels. Factors involved in the correlation between the iCa and tCa levels were evaluated using multiple regression analysis. Two hundred thirteen patients were enrolled. Patients were 65 ± 10.2 years old. The correlation coefficients were 0.8665 for iCa and tCa and 0.8537 for iCa and cCa. Correlations were also observed when divided by albumin concentration and pH, known correlation factors. In multiple regression analysis of the relationship between tCa and iCa, albumin, pH, phosphorus, and magnesium levels were significant factors. Based on these results, a new corrected calcium equation (mg/dL) = 0.828 × tCa − 0.314 × albumin (g/dL) + 0.007 × age + 2.922 was derived using age and albumin. There was a correlation between iCa, tCa, and cCa in hemodialysis patients.
Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study
Authors: Yang Yiwen , Chen Jiahui , Wen Qian , Jin Guangshan , Liu Fuqiang , Yu Ling , He Jianhua 
Published: October 2024

Abstract

Purpose: To investigate whether NACT increases the incidence of POD in patients with gynecological tumors undergoing radical hysterectomy.
Methods: This study included 60 patients in the neoadjuvant chemotherapy exposure group and 60 in the non-exposure group. Preoperative cognitive function, the incidence of POD and other physiological parameters were assessed on POD-1, and POD1-POD3. Additionally, preoperative olfactory function was evaluated using an olfactory detection kit on POD-1. The primary outcome was the incidence of POD within three days after surgery.
Results：The incidence of POD was 28.3% in the exposed group and 8.3% in the non-exposed group (P = 0.005). Compared to the non-exposed group, the exposed group had higher rate of cognitive dysfunction (33.33% vs 13.33%; P = 0.010), and a higher rate of OD (25.0% vs 10.0%; P = 0.031). A restricted cubic spline analysis revealed a non-linear relationship between olfactory test scores and MoCA scores (P for overall < 0.001, P for nonlinear = 0.001). Logistic regression identified NACT, mild and moderate cognitive dysfunction, OD, and depression as independent risk factors for POD, with all factors showing significant associations (P < 0.05). The AUC of OD for predicting POD was 0.783 (95%CI: 0.656-0.909).
Conclusions: This single-blind observational study suggests that NACT increases the incidence of POD in patients with gynecological tumors undergoing radical hysterectomy. Moreover, the results indicate that preoperative OD may reflect preoperative cognitive dysfunction, and have predictive value for the incidence of POD.
Effects of aquarobics participation on back pain disability index, sleep disturbance, and subjective memory impairment in female older adults with chronic back pain
Authors: Lee MoonSook , Kim Jiyoun 
Published: October 2024

Abstract

Background
Pain is a notable risk factor for cognitive decline in older adults. Aims: This study aimed to evaluate the effect of an aquarobics exercise program on three critical health outcomes—back Pain Disability Index (BPDI), sleep disturbance (SD), and subjective memory impairment (SMI) —in female older adults with chronic low back pain. Methods: In total, 152 participants were recruited and randomly assigned to either the experimental group (n = 68), which participated in a structured aquarobics program for three months, or the control group (n = 84), which did not engage in any structured exercise intervention. Results: Participation in the aquarobics program resulted in a statistically significant reduction in BPDI scores, indicating a marked decrease in functional limitations associated with chronic back pain. Participants in the experimental group exhibited significant improvements in sleep quality and decreased subjective memory impairment, both of which were positively correlated with reduced BPDI. SEM analysis confirmed that improvements in BPDI mediated positive effects on sleep and memory, suggesting that physical pain alleviation contributes to enhanced cognitive and psychological well-being. Discussion: These findings underscore the potential of aquarobics as a viable non-pharmacological intervention for elderly women with chronic low back pain, offering comprehensive benefits beyond pain relief, including enhancements in sleep and cognitive function. Conclusions: Future research should explore the long-term sustainability of these benefits and consider the integration of aquarobics into broader rehabilitation and wellness programs for older adults.