bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life of people with depression: pre-post intervention compared with age-matched general population in Vietnam
Authors: Hoa Truong Thi My , Ngan Tran Thu , Mai Vu Quynh , Van Minh Hoang , Thu Nguyen Khac , Nhu Tran Kieu 
Published: October 2024

Abstract
Background
In Vietnam, there is a paucity of health-related quality of life (HRQoL) research on people with depression as well as a lack of evidence on supported self-management (SSM) intervention for depression on HRQoL. This study aimed to compare the HRQoL of people with depression and age-matched people in the Vietnamese population, evaluate the effects of Tele-SSM intervention on HRQoL, and examine the association between the changes in HRQoL score and mental health well-being (depression, anxiety, and stress).

Methods
This study was a pre- and post-study involving Vietnamese adults aged 18–64 who had depression symptoms (score ≥ 5 points in the PHQ-9). Participants (N = 58) completed Tele-SSM—a supported self-management intervention incorporating cognitive behavioral therapy and non-violent communication and using a task-shifting approach. To compare with the general population, we conducted a 1-to-1 matching by age with an EQ-5D-5L valuation study with a nationally representative sample of the Vietnamese general population.

Results
HRQoL was significantly impaired in people with depression compared to the age-matched general population. Regarding health profile, participants reported the most difficulties in usual activities, pain/discomfort, and anxiety/depression dimensions. Significant improvements were observed in HRQoL scores post-intervention compared to pre-intervention in both EQ-VAS scores (from 59.84 to 79.48) and utility scores (from 0.79 to 0.90). These results remained lower than the age-matched general population (EQ-VAS score = 83.28, utility score = 0.96). Depression was associated with lower HRQoL while controlling for stress, anxiety symptoms and sociodemographic characteristics.

Conclusions
These results indicate that HRQoL is significantly impaired in people with depression and contribute to providing empirical evidence of Tele-SSM intervention in improving HRQoL. Further randomized controlled trials should be conducted to evaluate the effectiveness and cost-effectiveness of the Tele-SSM intervention.
Experiences and the psychosocial situation of parental caregivers of children with spinal muscular atrophy against the background of new treatment options: a qualitative interview study
Authors: Brandt Maja , Driemeyer Joenna , Johannsen Jessika , Denecke Jonas , Inhestern Laura , Bergelt Corinna 
Published: October 2024

Abstract
Background
Spinal muscular atrophy is a rare neurodegenerative disorder in children which leads untreated to muscle wasting, respiratory impairments, and a shortened life expectancy. Parents as primary caregivers are often physically and psychologically burdened. In recent years, new and promising treatment options have been approved, but it remains unclear if they have an impact on the psychosocial situation of affected families.

Objectives
The aim of this study was to explore the views and experiences of parents as informal caregivers of children with SMA in the course of the disease against the background of new treatment options (Spinraza® or Zolgensma®).

Methods
We conducted qualitative interviews with 27 parents of children with SMA treated with Spinraza® and Zolgensma® from April to September 2020. The analysis was done using thematic analysis and reported according to the COREQ criteria.

Results
The data analysis resulted in three main themes: a) caregiver burden and negative consequences for families, b) resources and protective aspects, c) psychosocial care needs. The results are discussed against the background of new treatment options and previous models of supportive care needs. Parental caregivers of affected children face multiple burdens in different stages of the child’s disease progression.

Conclusion
Although new treatment options for SMA showed observable effects for most parents, the main caregiver burden and reported symptoms were attributable to the overburdening care tasks. To unburden families, more screening for unmet needs, family-centered help services, professional caregivers, childcare, and sufficient financial support are needed.
Quasi-real-time earthquake relocation and monitoring in the northeastern Noto Peninsula
Authors: Matsumoto Ryuta , Yoshida Keisuke 
Published: October 2024

AbstractThe seismicity rate markedly increased in the northeastern Noto Peninsula of Ishikawa Prefecture around the end of 2020, with an Mw6.2 event on 5 May, 2023, followed by many aftershocks. Previous earthquake relocation studies have detected upward migration of microearthquakes via multiple faults and clusters, suggesting the involvement of crustal fluids in this sequence. Since some active faults exist near the source region, there was concern that this sequence could lead to a larger earthquake; it became a reality with the Mw7.5 earthquake on 1 January 2024. This study aims to develop an algorithm to precisely relocate microearthquake hypocenters in quasi-real time for better monitoring. A fine view of seismicity requires relative relocation methods such as the double-difference (DD) method with numerous arrival time difference data precisely measured by the waveform correlation analysis. However, the standard DD method has the disadvantage of huge computational costs when data increase, making it unsuitable for real-time monitoring in such situations. We developed a quasi-real-time algorithm that relocates only new earthquakes using the DD method each time a new time window of data is added. The major improvement is that our method incorporates a traditional simple relative relocation and preserves constraints between different time windows; the relative locations of new events are constrained from reference events that were already relocated in the previous time windows. We tested a daily relocation algorithm on 11,546 events from 19 June, 2022, to 31 May, 2023, in the Noto Peninsula earthquake sequence. We found that our modification substantially reduced artificial hypocenter offsets between different time windows and succeeded in resolving the fine fault structures from the cloud-like distribution of initial hypocenters. If we do not impose constraints between different windows, the relocated hypocenters are scattered and do not show fine planar structures. Our algorithm greatly reduces the computational cost, allowing for quasi-real-time earthquake relocation and monitoring. We hope this algorithm will help monitor the spatio-temporal distribution of future earthquake sequences.
Graphical Abstract
Prediction of lymphovascular invasion in esophageal squamous cell carcinoma by computed tomography-based radiomics analysis: 2D or 3D ?
Authors: Li Yang , Gu Xiaolong , Yang Li , Wang Xiangming , Wang Qi , Xu Xiaosheng , Zhang Andu , Yue Meng , Wang Mingbo , Cong Mengdi , Ren Jialiang , Ren Wei , Shi Gaofeng 
Published: October 2024

Abstract
Background
To compare the performance between one-slice two-dimensional (2D) and whole-volume three-dimensional (3D) computed tomography (CT)-based radiomics models in the prediction of lymphovascular invasion (LVI) status in esophageal squamous cell carcinoma (ESCC).

Methods
Two hundred twenty-four patients with ESCC (158 LVI-absent and 66 LVI-present) were enrolled in this retrospective study. The enrolled patients were randomly split into the training and testing sets with a 7:3 ratio. The 2D and 3D radiomics features were derived from the primary tumors’ 2D and 3D regions of interest (ROIs) using 1.0 mm thickness contrast-enhanced CT (CECT) images. The 2D and 3D radiomics features were screened using inter-/intra-class correlation coefficient (ICC) analysis, Wilcoxon rank-sum test, Spearman correlation test, and the least absolute shrinkage and selection operator, and the radiomics models were built by multivariate logistic stepwise regression. The performance of 2D and 3D radiomics models was assessed by the area under the receiver operating characteristic (ROC) curve. The actual clinical utility of the 2D and 3D radiomics models was evaluated by decision curve analysis (DCA).

Results
There were 753 radiomics features from 2D ROIs and 1130 radiomics features from 3D ROIs, and finally, 7 features were retained to construct 2D and 3D radiomics models, respectively. ROC analysis revealed that in both the training and testing sets, the 3D radiomics model exhibited higher AUC values than the 2D radiomics model (0.930 versus 0.852 and 0.897 versus 0.851, respectively). The 3D radiomics model showed higher accuracy than the 2D radiomics model in the training and testing sets (0.899 versus 0.728 and 0.788 versus 0.758, respectively). In addition, the 3D radiomics model has higher specificity and positive predictive value, while the 2D radiomics model has higher sensitivity and negative predictive value. The DCA indicated that the 3D radiomics model provided higher actual clinical utility regarding overall net benefit than the 2D radiomics model.

Conclusions
Both 2D and 3D radiomics features can be employed as potential biomarkers to predict the LVI in ESCC. The performance of the 3D radiomics model is better than that of the 2D radiomics model for the prediction of the LVI in ESCC.
A decision tree approach for investigating the background of research activity of community and hospital pharmacists in Mie Prefecture: a retrospective questionnaire-based survey
Authors: Asai Yuki , Takai Yasushi , Kato Hideo , Hiramatsu Shun-ichi , Miki Yoshihiro , Masuda Naoki , Iwamoto Takuya 
Published: October 2024

Abstract
Background
The support system for research activities has not been sufficiently established in clinical settings. A survey should be conducted to identify the causes of low research activity among pharmacists and the characteristics of pharmacists who could serve as mentors to build a support system at the regional level.

Methods
A retrospective cross-sectional survey was conducted with 156 pharmacists, including hospital and community pharmacists, who attended a webinar on research ethics held once a year in Mie Prefecture. Decision tree (DT) analysis was performed to extract the low research activities and pharmacists who could serve as mentors in research activities using independent factors identified by multivariate logistic regression analysis.

Results
The questionnaire response rate was 72.4% (113/156), and most respondents were community pharmacists (81.4%). In the DT model, pharmacists who did not belong to academic societies (78%, 46/59) or those who belonged to one or two academic societies but had no certifications (100%, 5/5) had low research activities. Pharmacists who read papers more than once a month and had a nearby mentor (73%, 11/15) were more likely to become mentors in research activities.

Conclusions
The combination of the number of academic societies and the presence of certifications determines the efforts in research activities. In addition to reading at least one paper monthly, the presence of a mentor for writing research papers may also be a crucial factor in becoming a mentor. The proposed DT model may be helpful in building a support system for research activities at the regional level.
The magnitude of chronic constipation and associated factors among type 2 diabetic patients in Harar, Eastern Ethiopia
Authors: Mogess Wubshet Nebiyu , Mihretie Tefera Belsty , Habte Mezgebu Legesse , Feyisa Teka Obsa , Areda Bilisuma Girma , Ahmed Ebsa Tofik , Diribsa Getahun Chala , Zeleke Mastewal , Alemseged Natan Muluberhan , Amentie Eyobel , Wodajo Tegenu Balcha , Borushe Tewekel Reshid 
Published: October 2024

Abstract
Background
Constipation, which affects 16% of adults worldwide, is a chronic health problem characterized by unsatisfactory frequency of bowel movements, causing pain, bloating or incomplete bowel movements. The study aims to assess the magnitude of chronic constipation and associated factors among T2DM patients attending the endocrinology outpatient clinic at Hiwot Fana Comprehensive Specialized University Hospital from January 1 to May 30, 2023.

Methods
Hospital-based cross-sectional study design was carried out to assess the magnitude and associated factors of chronic constipation among T2DM patients at Hiwot Fana Comprehensive Specialized University Hospital. Using a single population formula 300 T2DM patients were enrolled in this study. The data was analyzed by using the Epi-Data 4.6 and SPSS version 25. Descriptive, bivariate, multivariate, and logistic regression were used. P < 0.05 was used to declare association.

Results
300 T2DM patients participated in this survey. Of these 137 (45.7%) were male and 163 (54.3%) were female and the mean age was 58.57 ± 11.09 SD years, the range from 35 to 85 years. The prevalence of constipation was 73 (24.3%) (95% CI: 0.196–0.296). Education status above high school (AOR: 0.151.95% CI: 0.032–0.718), less than 7 h of sleep per day (AOR: 12.39.95% CI: 2.712–56.69), frequent depression (AOR: 6, 84, 95% CI: 2.639–17.743), parents with constipation (AOR: 6.843.95% CI: 2.639–17.743), daily water intake < 1300 ml (AOR: 4.760.95% CI: 1.146–19.773), TAG levels below 150 mg/dl (AOR: 0.050, 95% CI: 0.015–0.166), HbAlc between 6 and 7% (AOR: 0.013.95% CI: 0.001–0.132) ,HbAlc between 7.1 and 8% (AOR: 0.006, 95% CI: 0.001–0.067), and LDL levels were significantly associated with chronic constipation in T2DM patients.

Conclusions
The prevalence of chronic constipation was considerable in T2DM patients. Education level above high school, less than 7 h of sleep per day, frequent depression, parents with constipation, daily water intake < 1300 ml, TAG and HbAlc play a significant role in the development of chronic constipation in T2DM patients. T2DM patients can reduce the extent of constipation by treating the above problem in a timely and timely manner.
Unique bone histology of modern giant salamanders: a study on humeri and femora of Andrias spp.
Authors: Klein Nicole , Konietzko-Meier Dorota , Kalita Sudipta , Noda Masahiro , Ishikawa Sena , Taguchi Yuki , Anzai Wataru , Hayashi Shoji 
Published: October 2024

AbstractThe osteohistology of Andrias spp. is a pivotal analogue for large fossil non-amniotes (e.g., Temnospondyli), and the endangered status of this taxon underlines the importance of gathering information on its growth. We here present the first osteohistological study by petrographic thin sections of an ontogenetic series of humeri and femora of eight individuals of varying sizes (28.5–104 cm) and ages (2.5–32 years) of Andrias japonicus from the Hiroshima City Asa Zoological Park, Japan. In addition, two individuals of A. cf. davidianus of unknown age but of different size (62 cm and 94 cm) were studied. All samples of Andrias spp. show a primary avascular periosteal cortex made of parallel-fibred tissue around the ossification center in the petrographic thin sections. Mainly in small individuals, the fibers forming this tissue are very coarse and loosely organized. With increasing size and age, the coarse tissue is irregularly intermixed and later replaced with finer and better organized fibers. This histologic change is accompanied by a change from diffuse annuli in the inner cortex to distinct lines of arrested growth (LAGs) in the outer cortex. We interpret these changes in tissue and the appearance of distinct growth marks as indicating the onset of active reproduction. The lack of primary vascularization around the ossification center in our Andrias spp. sample is striking and contradicts other observations. Vascularity may be prone to plasticity and further studies are necessary. We hypothesize that the large osteocyte lacunae and the dense networks of canaliculi observed in our sample may have nourished the tissue instead of primary vascular canals. We measured the size of osteocyte lacunae of Andrias spp. in comparison to other Lissamphibia, and found them to be significantly larger throughout ontogeny. The periosteal cortex contains a high amount of thick Sharpey’s fibers all around the midshaft cross sections. The two samples of Andrias cf. davidianus show tissue and growth mark distribution similar to that observed in A. japonicus. However, the large individual of A. cf. davidianus differed in its extremely osteosclerotic condition and the retention of a small layer of calcified cartilage in the endosteal region of the femur. It remains unclear whether these differences are related to plasticity, taxonomy, sex, exogenous factors, or attributable to a regenerated but fully regrown leg. Although the present study is based on zoo-kept and not wild, animals, it yields important insights into osteohistological plasticity and growth patterns in giant salamanders.
How to leverage implementation research for equity in global health
Authors: Alonge Olakunle 
Published: October 2024

AbstractImplementation research (IR) is important for addressing equity in global health. However, there is limited knowledge on how to operationalize IR for health equity, and pathways for improving health equity through IR in global health settings. This paper provides an overview of guidance and frameworks for thinking about health equity as part of IR while noting the gaps in how this guidance and frameworks apply to global health. It proposes an approach to guide implementation teams in the application of IR for achieving equity in global health considering these gaps. It describes key equity considerations for different aspects of IR (i.e., implementation contexts, strategies, outcomes, and research designs). These considerations can be applied prospectively and retrospectively, and at different stages of IR. The paper further describes causal pathways, intervention levers, and strategies for achieving health equity in global health settings through IR. Central to these pathways is the power asymmetries among different actors involved in IR in global health and how these contribute to health inequities. The paper suggests recommendations and strategies for shifting the balance of power among these actors while addressing the structural and systemic determinants of health inequities as part of IR. Explicit considerations for health equity as part of implementation research and practice are needed for the achievement of global health goals. Such explicit considerations should look back as much as possible, and entail defining and analyzing health inequities and intervening on the underlying causes and mechanisms of health inequities as part of IR on a routine basis.
Quality in Acute Stroke Care (QASC) Germany: improving efficiency in stroke care with nurse-initiated FeSS-protocols
Authors: Cassier-Woidasky Anne-Kathrin , Middleton Sandy , Dale Simeon , Coughlan Kelly , D’Este Catherine , McInnes Elizabeth , Cadilhac Dominique A. , Pfeilschifter Waltraud 
Published: October 2024

Abstract
Background
Nurse-initiated supported implementation of protocols to manage fever, hyperglycaemia (sugar) and swallowing (FeSS) following acute stroke reduced 90-day death and disability in the landmark Australian Quality in Acute Stroke Care (QASC)-Trial. An international interprofessional collaboration sought to evaluate the effects of nurse-led FeSS implementation on FeSS Protocol adherence in German stroke units.

Methods
This pre-test/post-test study was conducted in eight German stroke units between 2020 and 2022. Stroke nurses as clinical champions, supported by the project team, conducted multidisciplinary workshops discussing pre-implementation medical record audit results, barriers and facilitators to FeSS Protocol implementation, developed action plans and provided education, with ongoing support from Australia. Medical record audit data were collected by nurses, pre-implementation and three months post-implementation.

Results
In 771 (pre-implementation) and 679 (post-implementation) patients there were improvements in overall FeSS adherence (pre 20%, post 28%; adjusted difference in proportions (95% CI) 11%, (5.1%, 16%); p < 0.001), adherence to hyperglycaemia (pre 43%, post 55%; adjusted difference 23%, (17%, 29%); p < 0.001) and swallowing (pre 52%, post 61%; adjusted difference 11%, (5.2%, 17%); p < 0.001) but not fever protocol (pre 76%, post 78%; adjusted difference 1.5%, (-2.6%, 5.7%); p = 0.474). Improvements also were noted in administration of anti-pyretics (pre 29%, post 59%; adjusted difference 32%, (20%, 44%); p < 0.001); and insulin (pre 41%, post 60%; adjusted difference 14%, (1.1%, 28%); p < 0.034) both within one hour, as well as in performing a swallow screen within 24 h of admission (pre 65%, post 74%; adjusted difference 18% (8.8%, 26%); p < 0.001).

Conclusions
Supported implementation of the FeSS Protocols significantly improved acute care for post stroke complications of fever, hyperglycaemia and dysphagia in terms of higher adherence and shorter time to treatment.

Trial registration
As this is a pre-test/post-test study and does not meet the WHO/ICMJE definition of a clinical trial, registration was not required.
Control system design for azimuth position of earth station antennas
Authors: Al-Mayyahi Auday , Aldair Ammar , Khalaf Zainab A. , Wang William 
Published: October 2024

AbstractSmart earth station antennas have been used for several decades in many applications, from satellite communications to space object detection and tracking. The accuracy of the azimuth position for such antennas plays a crucial role in most steerable ground station antennas. Satellite tracking and space object detection demand precise tracking capabilities from the Earth. Several methods and techniques have been developed and used in industry to control the directions of ground station antennas, including the azimuth position. The challenge of azimuth tracking is increasing with the demand for full-sky coverage and with the exponential increase in space objects, including man-made satellites and operational and nonoperational objects; thus, providing accurate tracking is a key technology that demands continuous enhancement and development. This article presents the use of a PID-proportional-integral-derivative controller, a slide mode controller and a fractional order PID controller. It also introduces a new methodology based on model predictive control (MPC). The manuscript provides the core design for each of these controllers and provides insight into the performance of each controller even in the presence of disturbance. The camel optimization algorithm (COA) was used to obtain the optimal design parameters of each controller in the considered scenarios.