bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: ELECTROPHILIC SUBSTITUTIONS OF OLEFINIC HYDROGENS. II. ACYLATION OF VINYL ETHERS AND N‐VINYL AMIDES
Authors: HOJO M. , MASUDA R. , KOKURYO Y. , SHIODA H. , MATSUO S. 
Published: March 2016

AbstractMit den Trihalogencarbonsäureanhydriden (II) oder mit dem gemischten Anhydrid (IX) werden Vinylverbindungen an der Vinylgruppe acyliert.
ChemInform Abstract: SYNTHESIS OF MONOMERS FOR CYCLOPOLYMERIZATION
Authors: KHOLODENKO G. E. , BALANDINA L. A. , LIKHTEROV V. R. , ETLIS V. S. 
Published: March 2016

AbstractDurch Umsetzung der β‐Chloräpfelsäurealkylester (I) mit Phosgen in Gegenwart von Pyridin werden die Diacrylate (III) hergestellt.
ChemInform Abstract: THE REACTION OF ARYLTHALLIUM(III) COMPOUNDS WITH METAL NITRITE. SYNTHESIS OF NITROARENES
Authors: UEMURA S. , TOSHIMITSU A. , OKANO M. 
Published: March 2016

AbstractDie Tl‐Verbb. (I) reagieren mit Na‐nitrit zu den Nitrobenzolderivaten (II).
ChemInform Abstract: PREPARATION OF 2‐ AND 4‐ALKYLPHENOLS BY REACTION OF 2‐ AND 4‐HYDROXYBENZYL PHENYL SULFONES WITH LITHIUM ALUMINUM HYDRIDE
Authors: KOUTEK B. , PAVLICKOVA L. , VELEK J. , SOUCEK M. 
Published: March 2016

AbstractDie Titelreaktion der Phenylsulfone (I) und (III), die durch Umsetzung entsprechender Alkohole und Na‐benzolsulfinat in Essigsäure dargestellt werden, führt zu den gewünschten 2‐ und 4‐Alkylphenolen (II) bzw. (IV) in hohen Ausbeuten.
ChemInform Abstract: SYNTHESIS OF SUBSTITUTED DIPHENYLAMINE‐2 CARBOXYLIC ACID HYDRAZIDES AND THEIR CONDENSATION PRODUCTS WITH CARBONYL COMPOUNDS
Authors: BAHADUR S. , GOEL A. K. , VARMA R. S. 
Published: March 2016

AbstractAus den Diphenylamin‐2‐carbonsäuren (I) entstehen über die Ester (II) die Hydrazide (III), die mit Aldehyden und Ketonen in die Hydrazone (IV) bzw. (V) übergeführt werden.
ChemInform Abstract: STUDIES ON THE OXIDATION OF HEXAMETHYLBENZENE. III. THE PREPARATION OF TETRAMETHYLPHTHALIC ANHYDRIDE
Authors: CHIBA K. , ENDO E. , SAKAMOTO T. , SATO E. , FUKUHARA R. , KOBAYASHI T. 
Published: March 2016

AbstractWird das Prehnitol (I) mit 5%iger Natronlauge unter milden Bedingungen (bei 75°C) hydrolysiert, so lassen sich nach l0 minütiger Reaktionsdauer, Salzbildung mit Ag+ und Überführung der Salze in die N‐ bzw. O‐Methylderivate aus dem Reaktionsprodukt die Verbindungen (Il)‐(V) [in einem früheren Reaktionsstadium auch eine kleine Menge des Benzoats (VI)] isolieren.
ChemInform Abstract: TOSYLSULFONIUM IONS AND ACYLSULFONIUM IONS
Authors: MINATO H. , YAMAGUCHI K. , MIURA T. , KOBAYASHI M. 
Published: March 2016

AbstractDer Thiosulfonsäureester (I) wird durch Trifluormethansulfonsäureester zum Sulfoniumsalz (III) methyliert.
ChemInform Abstract: AMINOKETENETHIOACETALS FROM α‐CHLORONITRILES
Authors: POUPAERT J. , BRUYLANTS A. 
Published: March 2016

AbstractDas α‐Chlornitril (I) addiert Äthylmercaptan in Gegenwart von HCl unter Bildung eines instabilen Imidothioesterhydrochlorids, das bei der Behandlung mit H2S in das Aminoketen‐thioacetal (II) und den Dithioessigsäureester (III) übergeht.
ChemInform Abstract: DEHYDROANNULENES. VI. SYNTHESIS AND PROPERTIES OF 1,6,12,17‐TETRAPHENYL‐2,4,13,15‐TETRAKISDEHYDRO(22)ANNULENE
Authors: AKIYAMA S. , NOMOTO T. , IYODA M. , NAKAGAWA M. 
Published: March 2016

AbstractDie Titelverbindung (VI) wird aus dem Aldehyd (I) über die Stufen (II)‐(V) dargestellt.
ChemInform Abstract: 1‐METHYLAMINO‐2,4‐DIBROMOANTHRAQUINONE
Authors: UFIMTSEV V. N. , TITOVA S. P. 
Published: March 2016

AbstractDie aus der Nitroanthrachinoncarbonsäure (I) durch Umsetzung mit Methylamin (II) in Gegenwart von Kupferbronze und Natronlauge entstehende Methylaminocarbonsäure (III) reagiert mit Brom in Schwefelsäure zu dem Dibromanthrachinon (IV).
ChemInform Abstract: MEDIUM‐SIZED CYCLOPHANES. XVIII. IODINE‐INDUCED CYCLOISOMERIZATION OF METHYL‐, ETHYL‐, AND ISOPROPYL‐(2.2)METACYCLOPHANES. Π‐BASICITY AND ADDITIONAL STRAIN ENERGY TERMS AS CONTROLLING FACTORS
Authors: SATO T. , TAKEMURA T. 
Published: March 2016

AbstractDie Cyclophane (I) bis (V) wurden nach bekannten Methoden dargestellt.
ChemInform Abstract: SYNTHESIS OF THE ENANTIOMERIC 2‐PYRROLIDINEACETIC ACIDS
Authors: CASSAL J.‐M. , FUERST A. , MEIER W. 
Published: March 2016

AbstractUmsetzung des aus dem L‐Prolin (Ia) bereiteten rohen Säurechlorids (Ib) oder rohen gemischten Anhydrids (Ic) mit Diazomethan liefert das kristalline Diazoketon (II) in je ca. 80% Ausbeute [daneben der Methylester von (Ia)], das unter Wolff‐Umlagerung zum Methylester (IIIa) umgesetzt wird.
ChemInform Abstract: CHIRAL BENZYLIDENE DERIVATIVES OF GLYCEROL
Authors: CARMAN R. M. , KIBBY J. J. 
Published: March 2016

AbstractDie chiralen Benzyliden‐Derivate von Glycerin (IVb), das (2R,4S)‐cis‐Isomere und das (2S,4S)‐trans‐Isomere, werden ausgehendvom D‐Glucose‐phenylosotriazol (I) durch Benzylierung mit (II), Na‐metaperjodat‐Oxidation der 5,6‐Monobenzyliden‐Derivate (III) zu den Aldehyden (IVa) und deren Reduktion synthetisiert.
ChemInform Abstract: PYRIMIDINES. LIV. RING TRANSFORMATIONS IN REACTIONS OF HETEROCYCLIC COMPOUNDS S WITH NUCLEOPHILES. (XIII). DEGENERATE RING TRANSFORMATIONS OF N‐METHYLPYRIMIDINIUM SALTS INTO 2‐SUBSTITUTED PYRIMIDINES
Authors: OOSTVEEN E. A. , VAN DER PLAS H. C. , JONGEJAN H. 
Published: March 2016

AbstractDurch [′5N,]Dotierung von (I) wird nachgewiesen, daß dessen Reaktion mit Benz‐ bzw. Pivalamidiniumchlorid (II) in EtONa/ EtOH zum Austausch der N‐C‐N‐Gruppierung im Pyrimidin (I) gegen die des Amidins (II) führt unter Bildung der nichtdotierten Pyrimidine (III).
ChemInform Abstract: α‐NAPHTHALENESELENONIC ACID
Authors: KOZLOV V. V. , MALYUSHINA V. M. 
Published: March 2016

AbstractDas Kaliumsalz der Naphthalinseleninsäure (I) läßt sich mit Kaliumpermanganat in verdünnter Kalilauge zu Selenonsäure (II) oxidieren.
ChemInform Abstract: TRIORGANOPHOSPHINE‐DICHLOROGERMYLENES
Authors: DU MONT W.‐W. , RUDOLPH G. 
Published: March 2016

AbstractTriphenyl‐, Triäthyl‐ und Tri‐tert.‐butylphosphin reagieren mit dem Ge‐dichlorid‐Dioxan‐Komplex (I) unter Verdrängung von Dioxan zu den Triorganylphosphin‐dichlorgerrnylenen (II).
ChemInform Abstract: CONCERNING THE FORMATION OF COMPOUNDS CONTAINING METAL‐TO‐METAL MULTIPLE BONDS. A STEREOSPECIFIC ALKYL‐FOR‐CHLORINE EXCHANGE REACTION INVOLVING COMPOUNDS WITH TUNGSTEN‐TO‐TUNGSTEN TRIPLE BONDS
Authors: CHISHOLM M. H. , EXTINE M. W. 
Published: March 2016

AbstractDie Reaktion zwischen anti‐WQCI, (NEt,)4 und Li‐CH, ‐SiMe3 in Hexan liefert anti‐W2(CH2 ‐SiMe3), (NEtz )4 , das unter thermodynamisch kontrollierten Bedingungen zu dem rotameren gauche‐Komplex isomerisiert.
ChemInform Abstract: TRIS(SARCOSINATO‐O,N(‐1))COBALT(III). A METAL COMPLEX WITH FORCED CONFIGURATION OF NITROGEN ATOMS
Authors: JURSIK F. , SYKOROVA D. , HAJEK B. 
Published: March 2016

AbstractEine Suspension von Co(III)‐hydroxid in Wasser reagiert mit Sarcosin zu dem Titelkomplex, von dem nur mer‐Isomere isoliert wurden.
ChemInform Abstract: The Syntheses and Properties of Bis(3‐hydroxy‐2‐methyl‐4‐pyronato) Complexes of Bivalent Metal Ions.
Authors: MORITA H. , SHIMOMURA S. , KAWAGUCHI S. 
Published: March 2016

AbstractDer Titelligand reagiert mit Metallsalzen in NaOH enthaltenen wäßrigen Äthanollösungen zu den Komplexen (I) und (II).
ChemInform Abstract: REACTIONS OF KETENE ACETALS. PART 7. TOTAL SYNTHESES OF THE TETRAMETHYL ETHERS OF THE 1‐ACYL‐2,4,5,7‐TETRAHYDROXYANTHRAQUINONES RHODOLAMPROMETRIN AND RHODOCOMATULIN
Authors: BANVILLE J. , BRASSARD P. 
Published: March 2016

AbstractDie Acylketenacetale (II) wurden durch Friedel‐Crafts‐Reaktion von Säurechloriden mit 1,1‐Dichloräthylen und anschließende Methoxydehalogenierung dargestellt.
ChemInform Abstract: SYNTHESES OF PEPTIDES WITH 3′,5′‐DIIODO‐L‐TYROSINE
Authors: PAWELCZAK K. , RZESZOTARSKA B. , NADOLSKA B. 
Published: March 2016

AbstractDas O‐Benzyl‐dijod‐tyrosin (Ia) läßt sich als Boc‐Derivat (Ib) oder Z‐Derivat (Ic) nach der Methode der gemischten Anhydride, z.B. mit dem Glycinester (II) zu den Peptidestern (IIIa) bzw. (IIIb) kuppeln.
ChemInform Abstract: AMINO SUGARS. XXVI. SYNTHESIS OF AMIDO‐BONDED DISACCHARIDES CONTAINING HEXOSAMINURONIC ACIDS
Authors: YOSHIMURA J. , ANDO H. , SATO T. , TSUCHIDA S. , HASHIMOTO H. 
Published: March 2016

AbstractDie N‐Acylierung von D‐Gluco‐ und D‐Mannosamin‐Derivaten mit D‐Gluco‐ und D‐Mannosaminuronsäuren [in Gegenwart von Dicyclohexylcarbodiimid/Triäthylamin (DCC/Et3N) in Pyridin] zu Disacchariden mit Amid‐Bindung wird beschrieben.
ChemInform Abstract: MODEL REACTIONS IN THE PSEUDONUCLEOSIDE SERIES
Authors: FISSEKIS J. D. , LEHNBERG J. W. , SWEET F. , LIPNICK R. L. 
Published: March 2016

Abstract2‐Furyl‐essigester (Ib), der aus der Säure (Ia) hergestellt wird, wird zu (II) formyliert und dann mit Harnstoff oder Thioharnstoff in die Kondensate (III)‐(V) übergeführt.
ChemInform Abstract: CYCLOPENTANONES. XVII‐ PROSTAGLANDIN SYNTHESIS INVOLVING THE LITHIUM‐LIQUID AMMONIA REDUCTION OF 3‐ALKYL‐4‐HYDROXY‐2‐(1′‐OCTYNYL)‐2‐CYCLOPENTENONES
Authors: DE CLERCQ P. , DE SMET M. , LEGEIN K. , VANHULLE F. , VANDEWALLE M. 
Published: March 2016

AbstractLi/NaH‐Reduktion des Cyclopentenons (Ia) in Gegenwart von Na‐äthylat liefert als Hauptprodukt das Desoxy‐8‐epi‐PGF,a (IIa), während bei der Reduktion von (Ia) in Gegenwart von Phenol hauptsächlich das Desoxy‐PGFlß (IIIa) (geringe Ausbeute) entsteht; neben (IIa) bzw. (IIIa) werden jeweils die entsprechenden Isomeren (IIIa) bzw. (IIa), verschiedene weitere Isomere sowie gesättigte Verbindungen gebildet.
ChemInform Abstract: CYCLIZATION OF POLYENES. XVII. SYNTHESIS AND PHEROMONE ACTIVITY OF DL‐NEOCEMBRENE
Authors: KITAHARA Y. , KATO T. , KOBAYASHI T. , MOORE B. P. 
Published: March 2016

AbstractDas Säurechlorid (I) wird über das Chlorketon (II) zu einer Mischung aus (III) und (IV) umgesetzt.
ChemInform Abstract: THE NEUTRON ACTIVATION ANALYSIS OF MERCURY IN SOIL
Authors: NAKANO S. , HONBOH J. , URABE N. 
Published: March 2016

AbstractNach der Bestrahlung (Neutronenfluß 2·1013n cm‐1s‐1) wird die Bodenprobe mit einer HF/HClO4‐Mischung aufgeschlossen, das Hg radiochemisch durch Solventextraktion mit Toluol aus wäßriger H2SO4/KJ‐Lösung abgetrennt und schließlich als HgS gefällt.
Der Warburg‐Effekt im Duell von Tumorzellen und Immunsystem
Authors: Hille‐Rehfeld Annette 
Published: March 2016

AbstractAuch fast hundert Jahre nach der ersten Beschreibung des Warburg‐Effekts bleibt der Grundstoffwechsel proliferierender Zellen ein spannendes Forschungsfeld, von dem nicht nur die Grundlagenforschung profitiert, sondern auch neue Impulse für die Pathophysiologie und Pharmakologie zu erwarten sind. Die vorgestellten Befunde haben Konsequenzen für die Tumortherapie. Einerseits können Therapieansätze, die auf Intervention im Glucose‐Stoffwechsel der Tumorzelle basieren, die körpereigene Abwehr schwächen. Andererseits könnte der doppelbödige Wirkmechanismus der PD‐L1‐Antikörper neue Perspektiven für gezielte Interventionen im Stoffwechsel der Tumoren eröffnen.
Industrielle Chemie im Überblick
Authors: Ralle Bernd 
Published: March 2016

AbstractThemen der technischen und industriellen Chemie sind in den Chemie‐Lehrplänen der Bundesländer kaum zu finden, sieht man einmal ab von ausgewählten klassischen Verfahren wie verschiedenen großtechnischen Elektrolysen oder der Eisen‐ und Stahlherstellung. Wer dennoch auf einem aktuellen Kenntnisstand bleiben möchte, dem sei die Seite www.essentialchemicalindustry.org ans Herz gelegt, die eine gut aufgebaute Zusammenstellung chemisch‐industrieller Verfahren enthält.
Improvement of Stability and Anticancer Activity of Chlorambucil‐Tetrapeptide Conjugate Vesicles
Authors: Zhang Wei , Zhu Wenjun , He Ruiyu , Fang Shuo , Zhang Yemin , Yao Chen , Ismail Muhammad , Li Xinsong 
Published: March 2016

AbstractChlorambucil is a classic nitrogen mustard drug that has been used in the treatment of cancers. It may induce neutropenia, thrombocytopenia and other side effects because of its short lifetime and off‐target effect. In this report, chlorambucil‐tetrapeptide (AAAK, A3K) conjugate vesicles were developed to improve the stability and bioactivity of chlorambucil. First of all, chlorambucil‐A3K conjugate was synthesized by solid phase synthesis strategy. Secondly, the chlorambucil‐A3K conjugate was assembled and characterized by critical aggregation concentration, circular dichroism, dynamic light scattering and transmission electron microscopy. The results indicated that the chlorambucil‐A3K conjugate can be assembled to form spherical vesicles with an average diameter of 390.5 nm, and high drug loading about 47.1% is reached. Surprisingly, the preliminary biological evaluation of the chlorambucil‐A3K conjugate vesicles revealed the best in vitro anticancer activity against HeLa, HepG‐2 and MCF‐7 cell lines compared with chlorambucil and chlorambucil‐A3K conjugate free drugs. Furthermore, conjugate vesicles showed excellent in vivo antitumoral activity. It can be partly attributed to their vesicular structure which isolates chlorambucil active moiety from aqueous solution to retard degradation before killing cancer cells. Therefore, chlorambucil‐peptide (A3K) conjugate vesicles may be an alternative delivery system of chlorambucil.
Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)‐Resistant CML Lines While Circumventing Pharmacokinetic Liabilities
Authors: Ali Ahmed M. , Gómez‐Biagi Rodolfo F. , Rosa David A. , Lai Ping‐Shan , Heaton William L. , Park Ji Sung , Eiring Anna M. , Vellore Nadeem A. , de Araujo Elvin D. , Ball Dan P. , Shouksmith Andrew E. , Patel Ami B. , Deininger Michael W. , O'Hare Thomas , Gunning Patrick T. 
Published: March 2016

AbstractPharmacologic blockade of the activation of signal transducer and activator of transcription 3 (STAT3) in tyrosine kinase inhibitor (TKI)‐resistant chronic myeloid leukemia (CML) cell lines characterized by kinase‐independent resistance was shown to re‐sensitize CML cells to TKI therapy, suggesting that STAT3 inhibitors in combination with TKIs are an effective combinatorial therapeutic for the treatment of CML. Benzoic acid‐ and hydroxamic acid‐based STAT3 inhibitors SH‐4‐054 and SH‐5‐007, developed previously in our laboratory, demonstrated promising activity against these resistant CML cell lines. However, pharmacokinetic studies in murine models (CD‐1 mice) revealed that both SH‐4‐054 and SH‐5‐007 are susceptible to glutathione conjugation at the para position of the pentafluorophenyl group via nucleophilic aromatic substitution (SNAr). To determine whether the electrophilicity of the pentafluorophenyl sulfonamide could be tempered, an in‐depth structure–activity relationship (SAR) study of the SH‐4‐054 scaffold was conducted. These studies revealed that AM‐1‐124, possessing a 2,3,5,6‐tetrafluorophenylsulfonamide group, retained STAT3 protein affinity (Ki=15 μm), as well as selectivity over STAT1 (Ki>250 μm). Moreover, in both hepatocytes and in in vivo pharmacokinetic studies (CD‐1 mice), AM‐1‐124 was found to be dramatically more stable than SH‐4‐054 (t1/2=1.42 h cf. 10 min, respectively). AM‐1‐124 is a promising STAT3‐targeting inhibitor with demonstrated bioavailability, suitable for evaluation in preclinical cancer models.
The Role of Size and Dimerization of Decorating Plasmonic Silver Nanoparticles on the Photoelectrochemical Solar Water Splitting Performance of BiVO4 Photoanodes
Authors: Valenti Marco , Kontoleta Evgenia , Digdaya Ibadillah A. , Jonsson Magnus P. , Biskos George , Schmidt‐Ott Andreas , Smith Wilson A. 
Published: March 2016

AbstractAg nanoparticles (NPs) are deposited on BiVO4 photoanodes to study their effect on the photoelectrochemical (PEC) water splitting performance of the semiconductor. 15 nm light‐absorbing NPs and 65 nm light scattering NPs were studied separately to compare their light trapping ability for enhancing the semiconductor's absorption through light concentration and light scattering, respectively. The 15 nm NPs enhanced the BiVO4 external quantum efficiency throughout the semiconductor's absorption range (e.g., ≈2.5 fold at λ=400 nm). However, when a hole scavenger was added to the electrolyte, no enhancement was observed upon NP deposition, indicating that the NPs only facilitate the injection of holes from the semiconductor surface to the electrolyte but do not enhance its absorption. On the other hand, the 65 nm scattering NPs not only facilitated hole injection to the electrolyte, but also enhanced the absorption of the semiconductor (by ≈6 %) through light scattering. Such a dual effect, i.e., of enhancing both the surface properties and the absorption of the semiconductor, makes light scattering Ag NPs an ideal decoration for PEC water splitting photoelectrodes.
Translational Dynamics of Lipidated Ras Proteins in the Presence of Crowding Agents and Compatible Osmolytes
Authors: Patra Satyajit , Erwin Nelli , Winter Roland 
Published: March 2016

AbstractRas proteins are small GTPases and are involved in transmitting signals that control cell growth, differentiation, and proliferation. Since the cell cytoplasm is crowded with different macromolecules, understanding the translational dynamics of Ras proteins in crowded environments is crucial to yielding deeper insight into their reactivity and function. Herein, the translational dynamics of lipidated N‐Ras and K‐Ras4B is studied in the bulk and in the presence of a macromolecular crowder (Ficoll) and the compatible osmolyte and microcrowder sucrose by fluorescence correlation spectroscopy. The results reveal that N‐Ras forms dimers due to the presence of its lipid moiety in the hypervariable region, whereas K‐Ras4B remains in its monomeric form in the bulk. Addition of a macromolecular crowding agent gradually favors clustering of the Ras proteins. In 20 wt % Ficoll N‐Ras forms trimers and K‐Ras4B dimers. Concentrations of sucrose up to 10 wt % foster formation of N‐Ras trimers and K‐Ras dimers as well. The results can be rationalized in terms of the excluded‐volume effect, which enhances the association of the proteins, and, for the higher concentrations, by limited‐hydration conditions. The results of this study shed new light on the association state of these proteins in a crowded environment. This is of particular interest for the Ras proteins, because their solution state—monomeric or clustered—influences their membrane‐partitioning behavior and their interplay with cytosolic interaction partners.
Evaluating Battery‐like Reactions to Harvest Energy from Salinity Differences using Ammonium Bicarbonate Salt Solutions
Authors: Kim Taeyoung , Rahimi Mohammad , Logan Bruce E. , Gorski Christopher A. 
Published: March 2016

AbstractMixing entropy batteries (MEBs) are a new approach to generate electricity from salinity differences between two aqueous solutions. To date, MEBs have only been prepared from solutions containing chloride salts, owing to their relevance in natural salinity gradients created from seawater and freshwater. We hypothesized that MEBs could capture energy using ammonium bicarbonate (AmB), a thermolytic salt that can be used to convert waste heat into salinity gradients. We examined six battery electrode materials. Several of the electrodes were unstable in AmB solutions or failed to produce expected voltages. Of the electrode materials tested, a cell containing a manganese oxide electrode and a metallic lead electrode produced the highest power density (6.3 mW m−2). However, this power density is still low relative to previously reported NaCl‐based MEBs and heat recovery systems. This proof‐of‐concept study demonstrated that MEBs could indeed be used to generate electricity from AmB salinity gradients.
Iron deficiency and risk of early readmission following a hospitalization for acute heart failure
Authors: Núñez Julio , Comín‐Colet Josep , Miñana Gema , Núñez Eduardo , Santas Enrique , Mollar Anna , Valero Ernesto , García‐Blas Sergio , Cardells Ingrid , Bodí Vicent , Chorro Francisco J. , Sanchis Juan 
Published: March 2016

AimsEarly rehospitalization after an episode of acute heart failure (AHF) remains excessively high and its prediction a contemporary challenge. Iron deficiency (ID) is a frequent finding in AHF, but its prognostic implications remain unclear. We sought to evaluate the association between ID and risk of 30‐day readmission in an unselected cohort of patients discharged for AHF.Methods and resultsSerum ferritin and transferrin saturation (TSAT) were measured before discharge in 626 consecutive patients with AHF in a single teaching centre. ID was defined as serum ferritin <100 µg/L (absolute ID) or ferritin 100–299 µg/L with a TSAT <20% (functional ID). Cox regression adapted for competing events was used to determine the association between ID and the risk of 30‐day readmissions. Mean age was 73.4 ± 10.4 years, 48% were females, and 52.1% showed an LVEF >50%. ID was identified in 463 patients (74%): 302 (48.2%) as absolute ID and 161 (25.7%) as functional ID. At 30‐day post‐discharge, 20 (3.2%) patients died and 103 (16.5%) were readmitted. Patients with absolute ID showed an increased rate of readmission compared with those with functional ID and no ID (19.9, 13, and 13.5%, respectively, P = 0.005). In a multivariate setting, absolute ID remained associated with higher risk of readmission [hazard ratio (HR) 1.72; 95% confidence interval (CI) 1.13–2.60, P = 0.011]. Compared with patients without ID, functional ID was not related to the risk of readmission (HR 0.87; 95% CI 0.46–1.62, P = 0.652).ConclusionIn patients with AHF, absolute ID, but not functional ID, was associated with an increased risk of early readmission.
2,2,2‐Trifluoroethyl Oxalates in the One‐Pot Parallel Synthesis of Hindered Aliphatic Oxamides
Authors: Bogolubsky Andrey V. , Moroz Yurii S. , Mykhailiuk Pavel K. , Pipko Sergey E. , Grishchenko Alexander V. , Zhemera Anton V. , Konovets Anzhelika I. , Doroschuk Roman A. , Dmytriv Yurii V. , Zaporozhets Olga A. , Tolmachev Andrey 
Published: March 2016

AbstractA simple parallel synthesis approach to unsymmetrical N1,N2‐substituted aliphatic oxamides using methyl (2,2,2‐trifluoroethyl) oxalate and bis(2,2,2‐trifluoroethyl) oxalate was developed. The method was validated on a 52‐membered set of the oxamides, derived mainly from hindered primary and secondary aliphatic amines, and gave the products with a high overall success rate in moderate yields.
Silatrane as a Practical and Selective Reagent for the Reduction of Aryl Aldehydes to Benzylic Alcohols
Authors: Skrypai Vladislav , Hurley Joseph J. M. , Adler Marc J. 
Published: March 2016

AbstractHydrosilanes are cheap, readily available substrates, yet they do not see as extensive use for simple carbonyl reductions as borohydrides. Hydrosilane reducing agents broadly fall into one of two general categories: either a) they are easy to handle and require expensive and/or hazardous additives, or b) they are difficult and/or dangerous to handle. This work details the discovery of mild and functional group compatible conditions utilizing hydrosilatrane for the selective reduction of aryl aldehydes to benzylic alcohols without unwanted formation of ethers or deoxygenated products. This method offers significant advances in silane reductions as silatrane is an air‐ and moisture‐stable yet relatively reactive reducing agent that can be used in benchtop open air reactions.
Organocatalytic Enantioselective Synthesis of P‐Stereogenic Chiral Oxazaphospholidines
Authors: Wang Lanlan , Du Zhijun , Wu Qiang , Jin Rizhe , Bian Zheng , Kang Chuanqing , Guo Haiquan , Ma Xiaoye , Gao Lianxun 
Published: March 2016

AbstractThe enantioselective synthesis of P‐stereogenic chiral organophosphines under organocatalysis is a challenging research field, and reports that use this approach are rare. Herein, we have developed the enantioselective synthesis of P‐stereogenic chiral oxazaphospholidines by using a bicyclic thiazole as the organocatalyst in the P–N and P–O bond‐forming reaction. The P‐chiral products were prepared in high yields with moderate enantioselectivities. The base that was used in this process had a significant influence on the enantioselectivity of the reaction and in some cases led to the opposite configuration of the P‐chiral center.