bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung function at term in extremely preterm-born infants: a regional prospective cohort study
Authors: Bentsen Mariann Haavik , Markestad Trond , Øymar Knut , Halvorsen Thomas 
Published: October 2017

ObjectivesTo compare lung function of extremely preterm (EP)-born infants with and without bronchopulmonary dysplasia (BPD) with that of healthy term-born infants, and to determine which perinatal characteristics were associated with lung function at term and how predictive these measurements were for later respiratory health in EP-born infants.MethodsPerinatal variables were recorded prospectively, and tidal breathing parameters were measured at term-equivalent age using electromagnetic inductance plethysmography. Respiratory morbidity was defined by hospital readmissions and/or treatment with asthma medications during the first year of life.ResultsFifty-two EP-born infants (mean gestational age 261, range 226–276weeks) and 45 term-born infants were included. There was evidence of significant airway obstruction, higher tidal volumes and increased minute ventilation in the EP-born infants with and without BPD, although generally more pronounced for those with BPD. Male gender, antenatal steroids and number of days on continuous positive airway pressure were associated with lung function outcomes at term. A prediction model incorporating two unrelated tidal breathing parameters, BPD, birth weight z-score and gender, predicted respiratory morbidity in the first year of life with good accuracy (area under the curve 0.818, sensitivity and specificity 81.8% and 75.0%, respectively).ConclusionLung function measured at term-equivalent age was strikingly abnormal in EP-born infants, irrespective of BPD. Tidal breathing parameters may be of value in predicting future pulmonary health in infants born premature.Trial registration numberNCT01150396; Results.
An enquiry based on a standardised questionnaire into knowledge, awareness and preferences concerning the care of familial hypercholesterolaemia among primary care physicians in the Asia-Pacific region: the “Ten Countries Study”
Authors: Pang Jing , Hu Miao , Lin Jie , Miida Takashi , Nawawi Hapizah M , Park Jeong Euy , Wu Xue , Ramli Anis S , Kim Ngoc Thanh , Kwok See , Gonzalez-Santos Lourdes E , Su Ta-Chen , Truong Thanh Huong , Soran Handrean , Yamashita Shizuya , Tomlinson Brian , Watts Gerald F 
Published: October 2017

ObjectiveTo determine physicians’ knowledge, awareness and preferences regarding the care of familial hypercholesterolaemia (FH) in the Asia-Pacific region.SettingA formal questionnaire was anonymously completed by physicians from different countries/regions in the Asia-Pacific. The survey sought responses relating to general familiarity, awareness of management guidelines, identification (clinical characteristics and lipid profile), prevalence and inheritance, extent of elevation in risk of cardiovascular disease (CVD) and practice on screening and treatment.ParticipantsPractising community physicians from Australia, Japan, Malaysia, South Korea, Philippines, Hong Kong, China, Vietnam and Taiwan were recruited to complete the questionnaire, with the UK as the international benchmark.Primary outcomeAn assessment and comparison of the knowledge, awareness and preferences of FH among physicians in 10 different countries/regions.Results1078 physicians completed the questionnaire from the Asia-Pacific region; only 34% considered themselves to be familiar with FH. 72% correctly described FH and 65% identified the typical lipid profile, with a higher proportion of physicians from Japan and China selecting the correct FH definition and lipid profile compared with those from Vietnam and Philippines. However, less than half of the physician were aware of national or international management guidelines; this was significantly worse than physicians from the UK (35% vs 61%, p<0.001). Knowledge of prevalence (24%), inheritability (41%) and CVD risk (9%) of FH were also suboptimal. The majority of the physicians considered laboratory interpretative commenting as being useful (81%) and statin therapy as an appropriate cholesterol-lowering therapy (89%) for FH management.ConclusionsThe study identified important gaps, which are readily addressable, in the awareness and knowledge of FH among physicians in the region. Implementation of country-specific guidelines and extensive work in FH education and awareness programmes are imperative to improve the care of FH in the region.
Bi-modal stimulation in the treatment of tinnitus: a study protocol for an exploratory trial to optimise stimulation parameters and patient subtyping
Authors: D’Arcy Shona , Hamilton Caroline , Hughes Stephen , Hall Deborah A , Vanneste Sven , Langguth Berthold , Conlon Brendan 
Published: October 2017

IntroductionTinnitus is the perception of sound in the absence of a corresponding external acoustic stimulus. Bimodal neuromodulation is emerging as a promising treatment for this condition. The main objectives of this study are to investigate the relevance of interstimulus timing and the choices of acoustic and tongue stimuli for a proprietary bimodal (auditory and somatosensory) neuromodulation device, as well as to explore whether specific subtypes of patients are differentially responsive to this novel intervention for reducing the symptoms of chronic tinnitus.Methods and analysisThis is a two-site, randomised, triple-blind, exploratory study of a proprietary neuromodulation device with a pre–post and 12-month follow-up design. Three different bimodal stimulation parameter sets will be examined. The study will enrol 342 patients, split 80:20 between two sites (Dublin, Ireland and Regensburg, Germany), to complete 12 weeks of treatment with the device. Patients will be allocated to one of three arms using a stepwise stratification according to four binary categories: tinnitus tonality, sound level tolerance (using loudness discomfort level of <60 dB SL as an indicator for hyperacusis), hearing thresholds and presence of a noise-induced audiometric profile. The main indicators of relative clinical efficacy for the three different parameter sets are two patient-reported outcomes measures, the Tinnitus Handicap Inventory and the Tinnitus Functional Index, after 12 weeks of intervention. Clinical efficacy will be further explored in a series of patient subtypes, split by the stratification variables and by presence of a somatic tinnitus. Evidence for sustained effects on the psychological and functional impact of tinnitus will be followed up for 12 months. Safety data will be collected and reported. A number of feasibility measures to inform future trial design include: reasons for exclusion, completeness of data collection, attrition rates, patient’s adherence to the device usage as per manufacturer’s instructions and evaluation of alternative methods for estimating tinnitus impact and tinnitus loudness.Ethics and disseminationThis study protocol is approved by the Tallaght Hospital/St. James’s Hospital Joint Research Ethics Committee in Dublin, Ireland, and by the Ethics Committee of the University Clinic Regensburg, Germany. Findings will be disseminated to relevant research, clinical, health service and patient communities through publications in peer-reviewed and popular science journals and presentations at scientific and clinical conferences.Trial registration numberThe trial is registered onClinicalTrials.gov(NCT02669069) Pre-results.
Reducing patient mortality, length of stay and readmissions through machine learning-based sepsis prediction in the emergency department, intensive care unit and hospital floor units
Authors: McCoy Andrea , Das Ritankar 
Published: October 2017

IntroductionSepsis management is a challenge for hospitals nationwide, as severe sepsis carries high mortality rates and costs the US healthcare system billions of dollars each year. It has been shown that early intervention for patients with severe sepsis and septic shock is associated with higher rates of survival. The Cape Regional Medical Center (CRMC) aimed to improve sepsis-related patient outcomes through a revised sepsis management approach.MethodsIn collaboration with Dascena, CRMC formed a quality improvement team to implement a machine learning-based sepsis prediction algorithm to identify patients with sepsis earlier. Previously, CRMC assessed all patients for sepsis using twice-daily systemic inflammatory response syndrome screenings, but desired improvements. The quality improvement team worked to implement a machine learning-based algorithm, collect and incorporate feedback, and tailor the system to current hospital workflow.ResultsRelative to the pre-implementation period, the post-implementation period sepsis-related in-hospital mortality rate decreased by 60.24%, sepsis-related hospital length of stay decreased by 9.55% and sepsis-related 30-day readmission rate decreased by 50.14%.ConclusionThe machine learning-based sepsis prediction algorithm improved patient outcomes at CRMC.
Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma
Authors: Kurihara-Shimomura Miyako , Sasahira Tomonori , Nakamura Hiroshi , Nakashima Chie , Kuniyasu Hiroki , Kirita Tadaaki 
Published: October 2017

AimsHead and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth most common cancer worldwide and has a high potential for locoregional invasion and nodal metastasis. Therefore, discovery of a useful molecular biomarker capable of predicting tumour progression and metastasis of OSCC is crucial. We have previously reported zinc finger AN1-type containing 4 (ZFAND4) as one of the most upregulated genes in recurrent OSCC using a cDNA microarray analysis. Although ZFAND4 has been shown to promote cell proliferation of gastric cancer, its expression and clinicopathological roles in OSCC remain unclear.MethodsIn this study, we examined ZFAND4 expression by immunohistochemistry in 214 cases of OSCC.ResultsHigh cytoplasmic expression of ZFAND4 was observed in 45 out of 214 (21%) patients with OSCC. Expression levels of ZFAND4 were strongly associated with metastasis to the lymph nodes (p=0.0429) and distant organs (p=0.0068). Cases with high expression of ZFAND4 had a significantly unfavourable prognosis compared with patients with low expression of ZFAND4 (p<0.0001). Furthermore, ZFAND4 overexpression was an independent poor prognostic factor for OSCC as determined by multivariate analysis using the Cox proportional hazards model (p<0.0001).ConclusionsThese results suggest that ZFAND4 is a useful marker for predicting metastasis and poor prognosis in patients with OSCC.
Altering the competitiveness of tame oat (Avena sativa L.) versus wild oat (Avena fatua L.) with phosphorus and seeding rate
Authors: May W.E. 
Published: October 2017

Currently, no in-crop herbicide is registered to control wild oat (Avena fatua L.) in tame oat (Avena sativa L.). Wild oat must be controlled in tame oat using other agronomic practices. The objective of this research was to determine if side-banded phosphorus (P) in combination with seeding rate would increase the competitiveness of tame oat with wild oat, increasing yield and quality. An experiment was conducted from 2003–2005 at Indian Head, SK. The experimental design was a strip-plot design with four replications. The strips were low and high wild oat density. A two-way factorial, seeding rate (150, 250, 350, and 450 plants m−2), and P rate (0, 15, and 30 kg P2O5 ha−1) were seeded across the strips. Phosphorus affected seed density, grain yield, oat biomass, and wild oat fecundity. Seeding rate affected most of the measured variables and interacted with wild oat and year. The application of P increased the competiveness of oat by increasing crop biomass by 7.6% and grain yield by 3.4% and decreasing wild oat seed from 1.26% to 0.76% in the harvested grain. Wild oat decreased grain yield by 23% in 2003, 4.4% in 2004, and 11% in 2005. Increasing the seeding rate increased grain yield by 5% when wild oat was present. Wild oat did not interfere with the uptake of side-banded P. Producers need to use both P fertilization and higher seeding rates to improve the competitiveness of tame oat and the management of wild oat in tame oat.
Square array photonic crystal fiber-based surface plasmon resonance refractive index sensor
Authors: Liu Min , Yang Xu , Zhao Bingyue , Hou Jingyun , Shum Ping 
Published: October 2017

Based on surface plasmon resonance (SPR), a novel refractive index (RI) sensor comprising a square photonic crystal fiber (PCF) is proposed to realize the detection of the annular analyte. Instead of hexagon structure, four large air-holes in a square array are introduced to enhance the sensitivity by allowing two polarization directions of the core mode to be more sensitive. The gold is used as the only plasmonic material. The design purpose is to reduce the difficulty in gold deposition and enhance the RI sensitivity. The guiding properties and the effects of the parameters on the performance of the sensor are numerically investigated by the Finite Element Method (FEM). By optimizing the structure, the sensor can exhibit remarkable sensitivity up to 7250 nm/RIU and resolution of [Formula: see text] RIU with only one plasmonic material, which is very competitive compared with the other reported externally coated and single-layer coated PCF-based SPR (PCF–SPR) sensors, to our best knowledge.
Maximal depth property of finitely generated modules
Authors: Rahimi Ahad 
Published: October 2017

Let [Formula: see text] be a Noetherian local ring and [Formula: see text] a finitely generated [Formula: see text]-module. We say [Formula: see text] has maximal depth if there is an associated prime [Formula: see text] of [Formula: see text] such that depth [Formula: see text]. In this paper, we study finitely generated modules with maximal depth. It is shown that the maximal depth property is preserved under some important module operations. Generalized Cohen–Macaulay modules with maximal depth are classified. Finally, the attached primes of [Formula: see text] are considered for [Formula: see text].
Opportunities for women, minorities in information retrieval
Authors: Kobayashi Mei 
Published: October 2017

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Mei Kobayashi describes activities to support diversity and inclusion at the annual meeting of the ACM Special Interest Group on Information Retrieval in Tokyo this summer.
How to Measure the Killer Microsecond
Authors: Primorac Mia , Bugnion Edouard , Argyraki Katerina 
Published: October 2017

Datacenter-networking research requires tools to both generate traffic and accurately measure latency and throughput. While hardware-based tools have long existed commercially, they are primarily used to validate ASICs and lack flexibility, e.g. to study new protocols. They are also too expensive for academics. The recent development of kernel-bypass networking and advanced NIC features such as hardware timestamping have created new opportunities for accurate latency measurements. This paper compares these two approaches, and in particular whether commodity servers and NICs, when properly configured, can measure the latency distributions as precisely as specialized hardware.
Our work shows that well-designed commodity solutions can capture subtle differences in the tail latency of stateless UDP traffic. We use hardware devices as the ground truth, both to measure latency and to forward traffic. We compare the ground truth with observations that combine five latency-measuring clients and five different port forwarding solutions and configurations. State-of-the-art software such as MoonGen that uses NIC hardware timestamping provides sufficient visibility into tail latencies to study the effect of subtle operating system configuration changes. We also observe that the kernel-bypass-based TRex software, that only relies on the CPU to timestamp traffic, can also provide solid results when NIC timestamps are not available for a particular protocol or device.
Transjugular intrahepatic portosystemic shunt: impact on systemic hemodynamics and renal and cardiac function in patients with cirrhosis
Authors: Busk Troels M. , Bendtsen Flemming , Poulsen Jørgen H. , Clemmesen Jens O. , Larsen Fin S. , Goetze Jens P. , Iversen Jens S. , Jensen Magnus T. , Møgelvang Rasmus , Pedersen Erling B. , Bech Jesper N. , Møller Søren 
Published: October 2017

Transjugular intrahepatic portosystemic shunt (TIPS) alleviates portal hypertension and possibly increases central blood volume (CBV). Moreover, renal function often improves; however, its effects on cardiac function are unclear. The aims of our study were to examine the effects of TIPS on hemodynamics and renal and cardiac function in patients with cirrhosis. In 25 cirrhotic patients, we analyzed systemic, cardiac, and splanchnic hemodynamics by catheterization of the liver veins and right heart chambers before and 1 wk after TIPS. Additionally, we measured renal and cardiac markers and performed advanced echocardiography before, 1 wk after, and 4 mo after TIPS. CBV increased significantly after TIPS (+4.6%, P < 0.05). Cardiac output (CO) increased (+15.3%, P < 0.005) due to an increase in stroke volume (SV) (+11.1%, P < 0.005), whereas heart rate (HR) was initially unchanged. Cardiopulmonary pressures increased after TIPS, whereas copeptin, a marker of vasopressin, decreased (−18%, P < 0.005) and proatrial natriuretic peptide increased (+52%, P < 0.0005) 1 wk after TIPS and returned to baseline 4 mo after TIPS. Plasma neutrophil gelatinase-associated lipocalin, renin, aldosterone, and serum creatinine decreased after TIPS (−36%, P < 0.005; −65%, P < 0.05; −90%, P < 0.005; and −13%, P < 0.005, respectively). Echocardiography revealed subtle changes in cardiac function after TIPS, although these were within the normal range. TIPS increases CBV by increasing CO and SV, whereas HR is initially unaltered. These results indicate an inability to increase the heart rate in response to a hemodynamic challenge that only partially increases CBV after TIPS. These changes, however, are sufficient for improving renal function. NEW & NOTEWORTHY For the first time, we have combined advanced techniques to study the integrated effects of transjugular intrahepatic portosystemic shunt (TIPS) in cirrhosis. We showed that TIPS increases central blood volume (CBV) through improved cardiac inotropy. Advanced echocardiography demonstrated that myocardial function was unaffected by the dramatic increase in preload after TIPS. Finally, renal function improved due to the increase in CBV. Recognition of these physiological changes significantly contributes to our clinical understanding of TIPS.
Diurnal variations in intestinal barrier integrity and liver pathology in mice: implications for alcohol binge
Authors: Voigt Robin M. , Forsyth Christopher B. , Shaikh Maliha , Zhang Lijuan , Raeisi Shohreh , Aloman Costica , Preite Nailliw Z. , Donohue Terrence M. , Fogg Louis , Keshavarzian Ali 
Published: October 2017

Recent studies suggest that circadian rhythms regulate intestinal barrier integrity, but it is not clear whether there are daily variations in barrier integrity. This study investigated daily variations in intestinal barrier integrity, including whether there are differences in alcohol-induced intestinal barrier dysfunction after an alcohol binge at different times of day and whether this is associated with concurrent liver injury. C57BL6/J male mice were fed a standard chow diet, an alcohol-containing liquid diet, or an alcohol control diet for 4 wk. During week 5 (i.e., on days 43–45), mice received three once-daily gavages of alcohol (6 g/kg) or the control (phosphate-buffered saline) at the same time each day. Immediately after the binge on the second day, intestinal permeability was assessed. Four hours after the third and final binge, mice were euthanized and tissue samples collected. The results demonstrated diet-specific and outcome-specific effects of time, alcohol, and/or time by alcohol interaction. Specifically, the alcohol binge robustly influenced markers of intestinal barrier integrity, and liver markers were robustly influenced by time of day. Only intestinal permeability (i.e., sucralose) demonstrated a significant effect of time and also showed a binge by time interaction, suggesting that the time of the alcohol binge influences colonic permeability. NEW & NOTEWORTHY This study investigated daily variations in intestinal barrier integrity, including whether there are differences in alcohol-induced intestinal barrier dysfunction after an alcohol binge at different times of day and whether this is associated with concurrent liver injury. We conclude that 1) alcohol binge significantly impacted markers of intestinal permeability, 2) time of day significantly affected liver outcomes, and 3) the time of day influenced colonic permeability.
Effects of contraction mode and stimulation frequency on electrical stimulation-induced skeletal muscle hypertrophy
Authors: Ashida Yuki , Himori Koichi , Tatebayashi Daisuke , Yamada Ryotaro , Ogasawara Riki , Yamada Takashi 
Published: October 2017

We compared the skeletal muscle hypertrophy resulting from isometric (Iso) or eccentric (Ecc) electrical stimulation (ES) training with different stimulation frequencies. Male Wistar rats were assigned to the Iso and Ecc groups. These were divided into three further subgroups that were stimulated at 10 Hz (Iso-10 and Ecc-10), 30 Hz (Iso-30 and Ecc-30), or 100 Hz (Iso-100 and Ecc-100). In experiment 1, the left plantarflexor muscles were stimulated every other day for 3 wk. In experiment 2, mammalian target of rapamycin complex 1 (mTORC1) signaling was investigated 6 h after one bout of ES. The contralateral right muscle served as a control (non-ES). Ecc contractions comprised forced dorsiflexion combined with ES. The peak torque and torque-time integral during ES were higher in the Ecc group than that in the Iso group in all stimulation frequencies examined. The gastrocnemius muscle weight normalized to body weight in ES side was increased compared with the non-ES side by 6, 7, and 17% in the Ecc-30, Iso-100, and Ecc-100 groups, respectively, with a greater gain in Ecc-100 than the Ecc-30 and Iso-100 groups. The p70S6K (Thr389) phosphorylation level was higher in the Ecc-30 and -100 than in the Iso-30 and -100 groups, respectively. The peak torque and torque-time integral were highly correlated with the magnitude of increase in muscle mass and the phosphorylation of p70S6K. These data suggest that ES-induced muscle hypertrophy and mTORC1 activity are determined by loading intensity and volume during muscle contraction independent of the contraction mode.NEW & NOTEWORTHY Eccentric contraction and high-frequency stimulation (HFS) are regarded as an effective way to increase muscle mass by electrical stimulation (ES) training. However, little is known about whether muscle hypertrophy is affected by contraction mode and stimulation frequency in ES training. Here, we provide the evidence that muscle hypertrophy and mammalian target of rapamycin complex 1 activity are determined by mechanical loading during contraction but not on the contraction mode itself, with a greater gain at HFS.