bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitudes and beliefs towards e-cigarettes among e-cigarette users and stop smoking advisors in South East England: a qualitative study
Authors: Tamimi Nancy 
Published: August 2017

Aim
To explore how e-cigarettes are perceived by a group of e-cigarette users and a group of Stop Smoking Advisors (SSAs), what are the risks and benefits they associate with e-cigarettes and how do these understandings shape participants’ attitude towards e-cigarettes?

Method
Face-to-face and phone interviews were conducted with 15 e-cigarette users and 13 SSAs in South East England between 2014 and 2015. Transcribed data were analysed inductively through thematic analysis.

Findings
E-cigarettes were used as a therapeutic aid to stop or cut down smoking and as a smoking substitute. A prominent theme is the uncertainty e-cigarettes have generated. This included ambiguity of e-cigarettes’ status and efficacy, and ambiguity of e-cigarettes’ physical and social risks. Different attitudes towards e-cigarettes were identified.

Conclusion
E-cigarettes’ benefits and risks should be continuously evaluated, put into perspective and circulated to avoid ambiguity. Stop smoking services need to recognise the benefits that can be gained by using e-cigarettes as a harm reduction tool.
The Role of Social-Identity Beliefs in the Trends of Foreign Policy of Iran
Authors: SHAHIDANI MEHDI HEDAYATI , PENKOVTSEV ROMAN VLADIMIROVICH 
Published: August 2017

AbstractValues and elements of popular culture play an important role in shaping and implementing the foreign policy of Iran. In this paper, using content analysis and after explaining the characteristics of Iranian identity, the author seeks to investigate the implications of Iranian social beliefs on foreign policy. In other words, the author sets out to explore whether the perceptions and attitudes of Iranian identity at different historical periods have been the basis according to which Iranian politicians have followed the same model or not? For this purpose, three major components, the influence in the regional area, xenophobia, and conspiracy theorythat are complementary in nature, have been selected. Research findings illustrate that the long history of societies like Iran has been the raison d'etre for the recurrence of social beliefs and values in various political eras of such societies.
Dynamics of antipolar distortions
Authors: Patel Kinnary , Prosandeev Sergey , Bellaiche Laurent 
Published: August 2017

AbstractMaterials possessing antipolar cation motions are currently receiving a lot of attention because they are fundamentally intriguing while being technologically promising. Most studies devoted to these complex materials have focused on their static properties or on their zone-center phonons. As a result, some important dynamics of antipolar cation distortions, such as the temperature behavior of their phonon frequencies, have been much less investigated, despite the possibility to exhibit unusual features. Here, we report the results and analysis of atomistic simulations revealing and explaining such dynamics for BiFeO3bulks being subject to hydrostatic pressure. It is first predicted that cooling such material yields the following phase transition sequence: the cubic paraelectric Pm$$\bar 3$$3̄m state at high temperature, followed by an intermediate phase possessing long-range-ordered in-phase oxygen octahedral tiltings, and then the Pnma state that is known to possess antipolar cation motions in addition to in-phase and antiphase oxygen octahedral tiltings. Antipolar cation modes are found to all have high phonon frequencies that are independent of temperature in the paraelectric phase. On the other hand and in addition to antipolar cation modes increasing in number, some phonons possessing antipolar cation character are rather soft in the intermediate and Pnma states. Analysis of our data combined with the development of a simple model reveals that such features originate from a dynamical mixing between pure antipolar cation phonons and fluctuations of oxygen octahedral tiltings, as a result of a specific trilinear energetic coupling. The developed model can also be easily applied to predict dynamics of antipolar cation motions for other possible structural paths bringing Pm$$\bar 3$$3̄m to Pnma states.
Restoration of quantum critical behavior by disorder in pressure-tuned (Mn,Fe)Si
Authors: Goko Tatsuo , Arguello Carlos J. , Hamann Andreas , Wolf Thomas , Lee Minhyea , Reznik Dmitry , Maisuradze Alexander , Khasanov Rustem , Morenzoni Elvezio , Uemura Yasutomo J. 
Published: August 2017

AbstractIn second-order quantum phase transitions from magnetically ordered to paramagnetic states at T = 0, tuned by pressure or chemical substitution, a quantum critical point is expected to appear with critical behavior manifesting in the slowing down of spin fluctuations in the paramagnetic state and a continuous development of the order parameter in the ordered state. Quantum criticality is discussed widely as a possible driving force for unconventional superconductivity and other exotic phenomena in correlated electron systems. In the real world, however, quantum critical points and quantum criticality are often masked by a preceding first-order transition and/or the development of competing states. Pressure tuning of the itinerant-electron helical magnet MnSi is a well-known example of the suppression of a quantum critical point due to a first-order phase transition and resulting destruction of the ordered state. Utilizing muon spin relaxation experiments, here we report that 15% Fe-substituted (Mn,Fe)Si exhibits completely different behavior with pressure tuning, including the restoration of second-order quantum critical behavior and a quantum critical point at p
QPC
~ 21–23 kbar, which coincides with the T = 0 crossing point of the extrapolated phase boundary line of pure MnSi. This result is quantitatively consistent with the recent theory of itinerant-electron ferromagnets by Sang, Belitz, and Kirkpatrick, who argued that disorder would restore a quantum critical point which is otherwise hidden by a first-order transition.
The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket
Authors: Thomas Anu , Sulli Chidananda , Davidson Edgar , Berdougo Eli , Phillips Morganne , Puffer Bridget A. , Paes Cheryl , Doranz Benjamin J. , Rucker Joseph B. 
Published: August 2017

AbstractAlthough bitter taste receptors (TAS2Rs) are important for human health, little is known of the determinants of ligand specificity. TAS2Rs such as TAS2R16 help define gustatory perception and dietary preferences that ultimately influence human health and disease. Each TAS2R must accommodate a broad diversity of chemical structures while simultaneously achieving high specificity so that diverse bitter toxins can be detected without all foods tasting bitter. However, how these G protein-coupled receptors achieve this balance is poorly understood. Here we used a comprehensive mutation library of human TAS2R16 to map its interactions with existing and novel agonists. We identified 13 TAS2R16 residues that contribute to ligand specificity and 38 residues whose mutation eliminated signal transduction by all ligands, providing a comprehensive assessment of how this GPCR binds and signals. Our data suggest a model in which hydrophobic residues on TM3 and TM7 form a broad ligand-binding pocket that can accommodate the diverse structural features of β-glycoside ligands while still achieving high specificity.
Nitrogen-doped carbon paper with 3D porous structure as a flexible free-standing anode for lithium-ion batteries
Authors: Zhang Hua , Yang Juntan , Hou Haoqing , Chen Shuiliang , Yao Haimin 
Published: August 2017

AbstractIn this paper, a novel nitrogen-doped carbon paper (NCP) with both highly dense three-dimensional cellular structure and excellent bending flexibility is fabricated by pyrolyzing a melamine foam under compression. When serving as a free-standing anode for lithium-ion batteries, the NCP electrode delivers a reversible capacity up to 329.8 mA h g−1 after 200 cycles at 0.5 A g−1 (1.34 C) and 126.5 mA h g−1 after 500 cycles at 8.0 A g−1 (21.5 C). Such electrochemical performance is much higher than those of the counterparts prepared by pyrolysis without compression and can be mainly attributed to (a) the 3D highly dense interconnected carbon network with numerous junctions which can facilitate the efficient electron transfer and provide short transportation paths for lithium ions; and (b) the excellent mechanical flexibility and self-standing capability which exempt the use of binder, conductive additive and current collector. The NCP electrode implies a great promise of application in the high-performance Li-ion batteries for the flexible and wearable electronics.
The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
Authors: Contaldi Felice , Capuano Federico , Fulgione Andrea , Aiese Cigliano Riccardo , Sanseverino Walter , Iannelli Domenico , Medaglia Chiara , Capparelli Rosanna 
Published: August 2017

AbstractThere is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases.
Identification of the novel 3′ UTR sequences of human IL-21 mRNA as potential targets of miRNAs
Authors: Enomoto Yutaka , Takagi Rie , Naito Yutaka , Kiniwa Tsuyoshi , Tanaka Yasuhito , Hamada-Tsutsumi Susumu , Kawano Masaaki , Matsushita Sho , Ochiya Takahiro , Miyajima Atsushi 
Published: August 2017

AbstractHepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma worldwide. However, the strategy of HBV to escape from the host immune system remains largely unknown. In this study, we examined extracellular vesicles (EVs) secreted from human hepatocytes infected with HBV. EVs includeing exosomes are nano-size vesicles with proteins, mRNAs, and microRNAs (miRNAs), which can be transmitted to different cells. We found that 104 EV associated miRNAs were increased in hepatocytes more than 2-fold by HBV infection. We then selected those that were potentially implicated in immune regulation. Among them, five HBV-induced miRNAs were found to potentially target multiple sequences in the 3′UTR of IL-21, a cytokine that induces anti-viral immunity. Moreover, expression of a reporter gene with the 3′ UTR of human IL-21 mRNA was suppressed by the five miRNAs individually. Finally, IL-21 expression in cloned human T cells was down-regulated by the five miRNAs. Collectively, this study identified the novel 3′ UTR sequences of human IL-21 mRNA and potential binding sites of HBV-induced EV-miRNAs.
The laccase-like reactivity of manganese oxide nanomaterials for pollutant conversion: rate analysis and cyclic voltammetry
Authors: Wang Xinghao , Liu Jiaoqin , Qu Ruijuan , Wang Zunyao , Huang Qingguo 
Published: August 2017

AbstractNanostructured manganese oxides, e.g. MnO2, have shown laccase-like catalytic activities, and are thus promising for pollutant oxidation in wastewater treatment. We have systematically compared the laccase-like reactivity of manganese oxide nanomaterials of different crystallinity, including α-, β-, γ-, δ-, and ɛ-MnO2, and Mn3O4, with 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) and 17β-estradiol (E2) as the probing substrates. The reaction rate behaviors were examined with regard to substrate oxidation and oxygen reduction to evaluate the laccase-like catalysis of the materials, among which γ-MnO2exhibits the best performance. Cyclic voltammetry (CV) was employed to assess the six MnOxnanomaterials, and the results correlate well with their laccase-like catalytic activities. The findings help understand the mechanisms of and the factors controlling the laccase-like reactivity of different manganese oxides nanomaterials, and provide a basis for future design and application of MnOx-based catalysts.
Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control
Authors: Tang Yubo , Tang Feng , Yang Yang , Zhao Lei , Zhou Hu , Dong Jinhua , Huang Wei 
Published: August 2017

AbstractDrug-antibody ratio (DAR) of antibody-drug conjugates (ADCs) is important for their therapeutic efficacy and pharmacokinetics, therefore control on DAR in synthesis process is a key for ADC quality control. Although various analytical methods were reported, the real-time monitoring on DAR is still a challenge because time-consuming sample preparation is usually needed during the analysis. Antibody deglycosylation of ADC simplifies DAR measurement, however long-time PNGaseF digestion for deglycosylation hampers the real-time detection. Here, we report a rapid DAR analysis within 15 min by robust deglycosylation treatment and LC-MS detection that enables real-time DAR monitoring for optimization on ADC synthetic process. With this approach, we were able to screen suitable conjugation conditions efficiently and afford the ADCs with expected DARs. To the best of our knowledge, this is the first report on real-time DAR analysis of ADCs for conjugation optimization and quality control, compatible with random lysine-linked ADCs, glycosite-specific ADCs, and the complicated dual-payload ADCs.
Assessing the effects of Cry1C rice and Cry2A rice to Pseudogonatopus flavifemur, a parasitoid of rice planthoppers
Authors: Tian Jun-Ce , Romeis Jörg , Liu Kai , Zhang Fa-Cheng , Zheng Xu-Song , Xu Hong-Xing , Chen Gui-Hua , He Xiao-Chan , Lu Zhong-Xian 
Published: August 2017

AbstractTransgenic rice producing insecticidal proteins from Bacillus thuringiensis (Bt) could help protect the plants from damage by lepidopteran pests. However, one concern is the potential of Bt rice to harm non-target natural enemies, which play a vital role in pest control. In the present study, the potential effects of Cry1C rice and Cry2A rice on different life-table parameters and population dynamics of Pseudogonatopus flavifemur, a parasitoid of rice planthoppers, were evaluated under laboratory and field condition. The exposure of P. flavifemur to plant-produced Bt proteins was also analyzed. Results indicated that direct feeding on rice plants was the main exposure pathway of P. flavifemur to the Cry1C and Cry2A proteins. No significant difference on the development, survival, longevity, fecundity, and prey consumption of P. flavifemur was detected over two generations between the Bt and non-Bt rice treatments. Furthermore, the population dynamics of P. flavifemur were not affected by Cry1C rice and Cry2A rice. In conclusion, the tested Cry1C rice and Cry2A rice do not appear to harm the parasitoid P. flavifemur.
Spiro-Phenylpyrazole/Fluorene as Hole-Transporting Material for Perovskite Solar Cells
Authors: Wang Yang , Su Tzu-Sen , Tsai Han-Yan , Wei Tzu-Chien , Chi Yun 
Published: August 2017

AbstractSpiro-OMeTAD with symmetric spiro-bifluorene unit has dominated the investigation of hole-transporting material (HTM) for efficient perovskite solar cells (PSCs) despite of its low intrinsic hole conductivity and instability. In this study, we designed and synthesized three asymmetric spiro-phenylpyrazole/fluorene base HTMs, namely: WY-1, WY-2 and WY-3. They exhibit excellent electrochemical properties and hole conductivities. Moreover, the PSC based on WY-1 exhibits the highest power conversion efficiency (PCE) of 14.2%, which is comparable to the control device employing spiro-OMeTAD as HTM (14.8%). These results pave the way to further optimization of both molecular design and device performance of the spiro-based HTMs.
Enhanced optical absorption via cation doping hybrid lead iodine perovskites
Authors: Tang Zhen-Kun , Xu Zhi-Feng , Zhang Deng-Yu , Hu Shu-Xian , Lau Woon-Ming , Liu Li-Min 
Published: August 2017

AbstractThe suitable band structure is vital for perovskite solar cells, which greatly affect the high photoelectric conversion efficiency. Cation substitution is an effective approach to tune the electric structure, carrier concentration, and optical absorption of hybrid lead iodine perovskites. In this work, the electronic structures and optical properties of cation (Bi, Sn, and TI) doped tetragonal formamidinium lead iodine CH(NH2)2PbI3 (FAPbI3) are studied by first-principles calculations. For comparison, the cation-doped tetragonal methylammonium lead iodine CH3NH3PbI3 (MAPbI3) are also considered. The calculated formation energies reveal that the Sn atom is easier to dope in the tetragonal MAPbI3/FAPbI3 structure due to the small formation energy of about 0.3 eV. Besides, the band gap of Sn-doped MAPbI3/FAPbI3 is 1.30/1.40 eV, which is considerably smaller than the un-doped tetragonal MAPbI3/FAPbI3. More importantly, compare with the un-doped tetragonal MAPbI3/FAPbI3, the Sn-doped MAPbI3 and FAPbI3 have the larger optical absorption coefficient and theoretical maximum efficiency, especially for Sn-doped FAPbI3. The lower formation energy, suitable band gap and outstanding optical absorption of the Sn-doped FAPbI3 make it promising candidates for high-efficient perovskite cells.
Multi-level Quantum Mechanics and Molecular Mechanics Study of Ring Opening Process of Guanine Damage by Hydroxyl Radical in Aqueous Solution
Authors: Liu Peng , Wang Qiong , Niu Meixing , Wang Dunyou 
Published: August 2017

AbstractCombining multi-level quantum mechanics theories and molecular mechanics with an explicit water model, we investigated the ring opening process of guanine damage by hydroxyl radical in aqueous solution. The detailed, atomic-level ring-opening mechanism along the reaction pathway was revealed in aqueous solution at the CCSD(T)/MM levels of theory. The potentials of mean force in aqueous solution were calculated at both the DFT/MM and CCSD(T)/MM levels of the theory. Our study found that the aqueous solution has a significant effect on this reaction in solution. In particular, by comparing the geometries of the stationary points between in gas phase and in aqueous solution, we found that the aqueous solution has a tremendous impact on the torsion angles much more than on the bond lengths and bending angles. Our calculated free-energy barrier height 31.6 kcal/mol at the CCSD(T)/MM level of theory agrees well with the one obtained based on gas-phase reaction profile and free energies of solvation. In addition, the reaction path in gas phase was also mapped using multi-level quantum mechanics theories, which shows a reaction barrier at 19.2 kcal/mol at the CCSD(T) level of theory, agreeing very well with a recent ab initio calculation result at 20.8 kcal/mol.
Performance on innate behaviour during early development as a function of stress level
Authors: Ryu Soojin , De Marco Rodrigo J. 
Published: August 2017

AbstractWhat is the relationship between the level of acute stress and performance on innate behaviour? The diversity of innate behaviours and lack of sufficient data gathered under the same experimental conditions leave this question unresolved. While evidence points to an inverted-U shaped relationship between the level of acute stress and various measures of learning and memory function, it is unknown the extent to which such a non-linear function applies to performance on innate behaviour, which develops without example or practice under natural circumstances. The fundamental prediction of this view is that moderate stress levels will improve performance, while higher levels will not. Testing this proposition has been difficult because it entails an overall effect that must be invariant to the nature of the stressor, the behaviour under scrutiny and the stimulus that drives it. Here, we report new experimental results showing that developing zebrafish (Danio rerio) under moderate but not higher levels of stress improved their performance on instinctive activities driven by visual, hydrodynamic and thermal inputs. Our findings reveal, for the first time, the existence of an inverted-U shaped performance function according to stress level during early development in a series of innate behaviours.
Metabolic networks for nitrogen utilization in Prevotella ruminicola
23
Authors: Kim Jong Nam , Méndez–García Celia , Geier Renae R. , Iakiviak Michael , Chang Jongsoo , Cann Isaac , Mackie Roderick I. 
Published: August 2017

AbstractNitrogen metabolism in gut systems remains poorly studied in spite of its importance for microbial growth and its implications for the metabolism of the host. Prevotella spp. are the most predominant bacteria detected in the rumen, but their presence has also been related to health and disease states in the human gut and oral cavity. To explore the metabolic networks for nitrogen assimilation in this bacterium, changes in gene expression profiles in response to variations in the available nitrogen source and to different concentrations of ammonium were analyzed by microarray and reverse transcription quantitative PCR, and linked with function by further proteomic analysis. The observed patterns of transcript abundances for genes involved in ammonium assimilation differed from the classical “enteric paradigm” for nitrogen utilization. Expression of genes encoding high substrate affinity nitrogen assimilation enzymes (GS-GOGAT system) was similar in growth-limiting and non-limiting nitrogen concentrations in P. ruminicola 23, whereas E. coli and Salmonella spp. responses to excess nitrogen involve only low substrate affinity enzymes. This versatile behavior might be a key feature for ecological success in habitats such as the rumen and human colon where nitrogen is rarely limiting for growth, and might be linked to previously reported Prevotella spp. population imbalances relative to other bacterial species in gut systems.
Anti-HMGCR Antibody–Related Necrotizing Autoimmune Myopathy Mimicking Muscular Dystrophy
Authors: Tiffreau Vincent , Jaillette Emmanuelle , Jouen Fabienne , Nelson Isabelle , Bonne Gisèle , Yaou Rabah , Romero Norma , Vallée Louis , Vermersch Patrick , Nguyen Sylvie , Maurage Claude-Alain , Cuisset Jean-Marie , Tard Céline 
Published: August 2017

Introduction Necrotizing autoimmune myopathies (NAMs) are acquired myopathies with myofibrillar necrosis and weak or absent inflammatory component, sometimes associated with anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies.
Observation The patient, a girl now aged 20 years, was first assessed at the age of 5 years for abnormal gait revealing frank pelvic deficit. Creatine kinase (CK) levels were as high as 7,500 IU/L. Subsequent muscle biopsy showed some necrosis, fiber regeneration, and fibrosis consistent with muscular dystrophy (MD). Protein immunohistochemistry was normal. The disease course was progressive until wheelchair use at the age of 9 years. At 12 years of age, a second muscle biopsy found an advanced MD with some perivascular inflammatory mononuclear cells. All molecular analyses done through 14 years of follow-up were negative till anti-HMGCR antibodies were detected at a significant amount when she was 19 years old.
Discussion NAMs begin at a pediatric age and may have a chronic course mimicking MDs. Muscular biopsy can be misleading with a predominantly dystrophic pattern without inflammation.
Conclusion This observation should prompt the assessment of NAMs in all MDs, even pediatric, without molecular solutions.