bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer Burden and Attributable Risk Factors of Cancers in China: Epidemiological Insights and Comparisons With India
Authors: Rahmat Syed Adnan , He Yutong 
Published: September 2024

Background Cancer is a major health concern in China. Understanding the epidemiology of cancer can guide the development of effective prevention and control strategies. This study aimed to comprehensively analyze the cancer burden, time trends, and attributable risk factors of cancers in China and compare them with those in India. Methods We utilized the GLOBOCAN database for 2022, Cancer Incidence in Five Continents (C15 plus) series, and Global Burden of Disease (GBD) 2021 to extract data on cancer incidence, mortality, disability-adjusted life years (DALYs), and risk factors. Time-trend analysis was performed using a join-point regression model. Correlations between cancer DALY rates and risk factors were analyzed using linear regression. Results In 2022, China experienced 4,824,703 new cancer cases and 2,574,176 cancer-related deaths. Cancers also caused approximately 71.2 million DALYs in China in 2021. Compared with India, China has higher incidence, mortality, and DALY rates for various cancers. Breast and thyroid cancers in China have shown a rapid increase in the age-standardized incidence rate (ASIR), along with a substantial burden of lung, stomach, esophageal, and colorectal cancer. However, stomach and liver cancers in China showed a downward trend in ASIR. In 2021, diet low in milk was a major risk factor among females for colorectal cancer DALYs in China (23% of age-standardized DALYs) and India (22.9%). In China, smoking has been associated with increased DALYs due to lung cancer. Conclusions China has a heavier cancer burden than India. The heavy burden of lung, stomach, esophageal, and colorectal cancers, combined with the rising incidence of breast and thyroid cancers, pose a critical challenge to public health in China. Cancer burden may be reduced through public health initiatives that prioritize primary prevention, prompt identification, and therapeutic intervention.
SMU1 Knockdown Suppresses Gastric Carcinoma Growth, Migration, and Invasion and Modulates the Cell Cycle
Authors: Qian Meirui , Liang Xue , Zeng Qingmei , Zhang Chen , He Nan , Ma Jing 
Published: September 2024

Introduction The role of SMU1 in DNA replication and RNA splicing is well-established, yet its specific function and dysregulated mechanisms in gastric cancer (GC) remain inadequately elucidated. This study seeks to investigate the potential oncogenic and progression-promoting effects of SMU1 in GC, with the ultimate goal of informing novel approaches for treatment and diagnosis. Methods The study investigated the expression levels of SMU1 in GC and adjacent normal tissues by analyzing data from the TCGA (27 tissue pairs) and GEO (47 tissue pairs) databases. Immunohistochemistry was used to examine 277 tumor tissue and adjacent non-tumor tissue spots from GC tissue chips, along with relevant follow-up information. The study further assessed the proliferation, invasion, and migration capabilities of cells by manipulating SMU1 expression levels and conducting various assays, including CCK-8, EdU incorporation, colony formation, transwells, flow cytometry, and subcutaneous tumorigenesis assays. Results Our study revealed a significant upregulation of SMU1 mRNA and protein levels in GC tissues compared to adjacent tissues. Univariate and multivariate Cox analysis demonstrated that elevated levels of SMU1 were independent prognostic factors for GC prognosis ( P = 0.036). Additionally, median survival analysis indicated a significant association between high SMU1 expression and poor prognosis in GC patients ( P = 0.0002). In experiments conducted both in vivo and in vitro, it was determined that elevated levels of SMU1 can enhance the proliferation, invasion, and migration of GC cells, whereas suppression of SMU1 can impede the progression of GC by modulating the G1/S checkpoint of the cell cycle. Conclusions Our research introduces the novel idea that SMU1 could serve as a prognostic marker for GC progression, influencing cell proliferation through cell cycle activation. These results offer valuable insights into the understanding, diagnosis, and management of gastric carcinoma.
The coupled band gap of longitudinal wave in metamaterial-based double-rod containing resonators
Authors: Deng Ziwei , Zhang Baocheng , Zhang Kai , Peng Lei , Liu Peng , Sun Qihang , Pang Fuzhen 
Published: September 2024

This study investigates the coupled band gap and vibration propagation characteristics of elastic waves in a metamaterial elastic double-rod system with attached periodic resonators. We derive the band gap structure and vibration attenuation equations of double-rod structure using the spectral element method, Bloch’s theorem, and the transfer matrix method. The validity of the coupled band gap is confirmed through forced vibration response analysis. Furthermore, we examine the effects of various parameters on the double-rod system, revealing that coupled band gaps exist with the average vibration attenuation rates of −50.23 dB for rod one and −47.87 dB for rod two, respectively. Remarkably, by adjusting the double-rod parameters, both the band gap frequency range and vibration attenuation ability of the coupled band gap can be adjusted to meet specific engineering requirements in low-frequency regions. This research contributes to developing continuous mechanical structures featuring coupled band gaps.
Development of an electromagnetic compatible composite-insert embedded in a double-curved sandwich panel
Authors: Mokhtari Majid 
Published: September 2024

Composite sandwich structures, which are widely employed in engineering structures, require a multitude of inserts. In certain instances, the necessity for a specialized insert arises from the unique characteristics of a particular application. In applications such as weather radar radomes, double-curved sandwich panels should be designed with electromagnetic (EM) transparency as a primary objective. The use of metal inserts should be restricted to the absolute minimum. Given the limitations of using metal materials to protect against EM radiation and the need to enhance the load-bearing capacity of the joint against pull-out loads, a composite insert has developed as an innovative solution. In this study, a composite insert of a double-curved sandwich dome has been developed using silica nanoparticles, and its mechanical strength against pull-out load has been evaluated through both experimental and numerical analysis. The strength results obtained have been compared with analytical estimates. Additionally, the buckling of the double-curved sandwich dome against a wind speed of 220 km/h has been investigated numerically. The critical buckling load for wind loading for the full-scale sandwich radome was estimated to be 16,303 N. According to the numerical results obtained with the Abaqus finite element (FE) software, the maximum pull-out force applied to the connection area is approximately 10.7 kN. A parametric study of geometric variables and experimental results showed that it is possible to achieve a stronger composite insert (by 1 wt % nano silica particles) by 20.7% lighter and 102.65% more bearing capacity.
Impact response and compression-after-impact properties of foam-core sandwich composites incorporating scrap tyre rubber particles
Authors: Buddhacosa Nathaphon , Ibrahim Matthew , Charnsethikul Chananya , Santivongskul Parichamon , Khatibi Akbar , Das Raj , Kandare Everson 
Published: September 2024

Integrating scrap rubber particles as fillers into polymer matrix composites offers a cost effective and environmentally sustainable pathway to manage tyre waste through the creation of value-added products. This research explores the low-velocity impact (LVI) response and compression after impact (CAI) properties of rubberised foam-core glass fibre-reinforced epoxy (GFRE) sandwich composites. Syntactic foam cores integrated with rubber particles were manufactured using vacuum-assisted resin transfer moulding (VARTM). The compression properties of rubberised foam core, vital for resisting impact damage during LVI, were examined. Results show more than 40% reduction in compression strength and modulus of the syntactic foam upon the inclusion of 33 wt.% rubber particles. The LVI response and residual compression properties of rubberised foam-core composites were also evaluated. Rubberised foam cores caused a marginal reduction in the peak impact force and led to approximately 60% reduction in the delamination area. The pre-impact compression strength was unaffected by rubber particles within the core as the GFRE face sheets carried most of the compression load. Post-impact compression strength was slightly higher in rubberised foam-core composites due to reduced delamination. Digital Image Correlation (DIC) analysis tracking of the strain evolution during CAI experiments revealed the stress-raising effect of the impact damaged region. This study showcases sustainable scrap tyre management through the inclusion of rubber particles into foam-core composites without substantially reducing in-plane compression properties before or after low-velocity impact.
Characterization of Expression-Based Gene Clusters Gives Insights into Variation in Patient Response to Cancer Therapies
Authors: Neary Bridget , Qiu Peng 
Published: September 2024

Background: Transcriptomics can reveal much about cellular activity, and cancer transcriptomics have been useful in investigating tumor cell behaviors. Patterns in transcriptome-wide gene expression can be used to investigate biological mechanisms and pathways that can explain the variability in patient response to cancer therapies. Methods: We identified gene expression patterns related to patient drug response by clustering tumor gene expression data and selecting from the resulting gene clusters those where expression of cluster genes was related to patient survival on specific drugs. We then investigated these gene clusters for biological meaning using several approaches, including identifying common genomic locations and transcription factors whose targets were enriched in these clusters and performing survival analyses to support these candidate transcription factor-drug relationships. Results: We identified gene clusters related to drug-specific survival, and through these, we were able to associate observed variations in patient drug response to specific known biological phenomena. Specifically, our analysis implicated 2 stem cell-related transcription factors, HOXB4 and SALL4, in poor response to temozolomide in brain cancers. In addition, expression of SNRNP70 and its targets were implicated in cetuximab response by 3 different analyses, although the mechanism remains unclear. We also found evidence that 2 cancer-related chromosomal structural changes may impact drug efficacy. Conclusion: In this study, we present the gene clusters identified and the results of our systematic analysis linking drug efficacy to specific transcription factors, which are rich sources of potential mechanistic relationships impacting patient outcomes. We also highlight the most promising of these results, which were supported by multiple analyses and by previous research. We report these findings as promising avenues for independent validation and further research into cancer treatments and patient response.
Comprehensive Analysis of CCAAT/Enhancer Binding Protein Family in Ovarian Cancer
Authors: Tan Jiahong , Wang Daoqi , Dong Wei , Nian Lei , Zhang Fen , Zhao Han , Zhang Jie , Feng Yun 
Published: September 2024

Background: Ovarian cancer has brought serious threats to female health. CCAAT/enhancer binding proteins (C/EBPs) are key transcription factors involved in ovarian cancer. Therefore, comprehensive profiling C/EBPs in ovarian cancer is needed. Methods: A comprehensive analysis concerning C/EBPs in ovarian cancer was performed. Firstly, detailed expression of C/EBP family members was integrally retrieved and then confirmed using immunohistochemistry. The regulatory effects and transcription regulatory functions of C/EBPs were studied by using regulatory network analysis and enrichment analysis. Using survival analysis, receiver operating characteristic curve analysis, and target-disease association analysis, the predictive prognostic value of C/EBPs on survival and drug responsiveness was systematically evaluated. The effects of C/EBPs on tumor immune infiltration were also assessed. Results: Ovarian cancer tissues expressed increased CEBPA, CEBPB, and CEBPG but decreased CEBPD when compared with normal control tissues. The overall alteration frequency of C/EBPs in ovarian cancer was approaching 30%. C/EBP family members formed a reciprocal regulatory network involving carcinogenesis and had pivotal transcription regulatory functions. C/EBPs could affect survival of ovarian cancer and correlated with poor survival outcomes (OS: HR = 1.40, P = .0053 and PFS: HR = 1.41, P = .0036). Besides, expression of CEBPA, CEBPB, CEBPD, and CEBPE could predict platinum and taxane responsiveness of ovarian cancer. C/EBPs also affected immune infiltration of ovarian cancer. Conclusions: C/EBPs were closely involved in ovarian cancer and exerted multiple biological functions. C/EBPs could be exploited as prognostic and predictive biomarkers in ovarian cancer.
Identifying Patient Subpopulations with Significant Race-Sex Differences in Emergency Department Disposition Decisions
Authors: Lin Peter , Argon Nilay T. , Cheng Qian , Evans Christopher S. , Linthicum Benjamin , Liu Yufeng , Mehrotra Abhishek , Murphy Laura , Patel Mehul D. , Ziya Serhan 
Published: September 2024

Background/objectives: The race-sex differences in emergency department (ED) disposition decisions have been reported widely. Our objective is to identify demographic and clinical subgroups for which this difference is most pronounced, which will facilitate future targeted research on potential disparities and interventions. Methods: We performed a retrospective analysis of 93 987 White and African-American adults assigned an Emergency Severity Index of 3 at 3 large EDs from January 2019 to February 2020. Using random forests, we identified the Elixhauser comorbidity score, age, and insurance status as important variables to divide data into subpopulations. Logistic regression models were then fitted to test race-sex differences within each subpopulation while controlling for other patient characteristics and ED conditions. Results: In each subpopulation, African-American women were less likely to be admitted than White men with odds ratios as low as 0.304 (95% confidence interval (CI): [0.229, 0.404]). African-American men had smaller admission odds compared to White men in subpopulations of 41+ years of age or with very low/high Elixhauser scores, odds ratios being as low as 0.652 (CI: [0.590, 0.747]). White women were less likely to be admitted than White men in subpopulations of 18 to 40 or 41 to 64 years of age, with low Elixhauser scores, or with Self-Pay or Medicaid insurance status with odds ratios as low as 0.574 (CI: [0.421, 0.784]). Conclusions: While differences in likelihood of admission were lessened by younger age for African-American men, and by older age, higher Elixhauser score, and Medicare or Commercial insurance for White women, they persisted in all subgroups for African-American women. In general, patients of age 64 years or younger, with low comorbidity scores, or with Medicaid or no insurance appeared most prone to potential disparities in admissions.
Investigation of health care use and a possible prodrome before the first attack in NMOSD and MOGAD
Authors: Rotstein Dalia L , Freedman Mark S , Konig Andrea , Lee Liesly , Luo Jin , Maxwell Colleen , Morrow Sarah A , Tremlett Helen , Vyas Manav V , Marrie Ruth Ann 
Published: September 2024

Background: Prodromal phases are well recognized in many inflammatory and neurodegenerative diseases, including multiple sclerosis. We evaluated the possibility of a prodrome in aquaporin-4 antibody positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using health administrative data. Methods: We investigated individuals with AQP4 + NMOSD and MOGAD, confirmed by medical chart review, in Ontario, Canada. Each NMOSD and MOGAD participant was matched 1:5 to general population controls by sex, birth year, immigrant status, and region. Total outpatient visits and hospitalizations were compared in the 5 years preceding the incident attack in multivariable negative binomial models. Results: We identified 96 people with AQP4 + NMOSD, matched to 479 controls, and 61 people with MOGAD, matched to 303 controls. In the 5 years preceding the incident attack, health care use was elevated for outpatient visits and hospitalizations for the NMOSD cohort (adjusted rate ratio (aRR): 1.47; 95% confidence interval (CI): 1.25–1.73; aRR: 1.67; 95% CI: 1.19–2.36, respectively) but not for MOGAD. Rate ratios steadily increased in NMOSD for outpatient visits in the 2 years preceding the incident attack. Conclusion: Our findings support a prodromal phase preceding clinical onset of AQP4 + NMOSD. Earlier recognition and management of NMOSD patients may be possible.
The ankle–brachial index, gastrocnemius mitochondrial respirometry, and walking performance in people with and without peripheral artery disease
Authors: McDermott Mary M , Dayanidhi Sudarshan , Leeuwenburgh Christiaan , Wohlgemuth Stephanie E , Ferrucci Luigi , Peterson Charlotte A , Tian Lu , Sufit Robert , Zhao Lihui , Slysz Joshua , Polonsky Tamar S , Guralnik Jack M , Kibbe Melina R , Ho Karen J , Criqui Michael H , Zhang Dongxue , Xu Shujun , Greenland Philip 
Published: September 2024

Background: Mitochondrial abnormalities exist in lower-extremity peripheral artery disease (PAD), yet the association of the ankle–brachial index (ABI) with mitochondrial respiration in gastrocnemius muscle is unknown. The association of gastrocnemius mitochondrial respiration with 6-minute walk distance in PAD is unknown. This objective of this study was to describe associations of the ABI with mitochondrial respiratory function in gastrocnemius muscle biopsies and associations of gastrocnemius mitochondrial respirometry with 6-minute walk distance in people with and without PAD. Methods: People with (ABI ⩽ 0.90) and without (ABI 1.00–1.40) PAD were enrolled. ABI and 6-minute walk distance were measured. Mitochondrial function of permeabilized myofibers from gastrocnemius biopsies was measured with high-resolution respirometry. Results: A total of 30 people with PAD (71.7 years, mean ABI: 0.64) and 68 without PAD (71.8 years, ABI: 1.17) participated. In non-PAD participants, higher ABI values were associated significantly with better mitochondrial respiration (Pearson correlation for maximal oxidative phosphorylation PCI+II: +0.29, p = 0.016). In PAD, the ABI correlated negatively and not significantly with mitochondrial respiration (Pearson correlation for PCI+II: –0.17, p = 0.38). In people without PAD, better mitochondrial respiration was associated with better 6-minute walk distance (Pearson correlation: +0.51, p < 0.001), but this association was not present in PAD (Pearson correlation: +0.10, p = 0.59). Conclusions: Major differences exist between people with and without PAD in the association of gastrocnemius mitochondrial respiration with ABI and 6-minute walk distance. Among people without PAD, ABI and walking performance were positively associated with mitochondrial respiratory function. These associations were not observed in PAD.
Characterizing self-reported physical activity before and during a subsequent pregnancy among parents in a familial autism cohort
Authors: G Bragg Megan , Vesey Olivia , Chavarro Jorge E , Hart Jaime E , Tabb Loni Philip , Weisskopf Marc G , Croen Lisa A , Fallin Daniele , Hertz-Picciotto Irva , Newschaffer Craig , Schmidt Rebecca J , Volk Heather , Lyall Kristen 
Published: September 2024

Parents of autistic children report barriers to engaging in physical activity, which may be exacerbated during subsequent pregnancies. We aimed to describe physical activity of parents caring for an autistic child, before and during a subsequent pregnancy, and to explore whether physical activity was associated with the autistic child’s Social Responsiveness Scale score, a measure of autism-related traits. We used data from the Early Autism Risk Longitudinal Investigation, in which families with an autistic child were followed through a subsequent pregnancy. Mothers ( n = 245) self-reported physical activity in the 3 months before conception and during pregnancy; fathers ( n = 130) reported on the 6 months prior to enrollment. Approximately 40% of nonpregnant mothers and fathers and 9.3% of pregnant mothers met Physical Activity Guidelines for Americans recommendations. Most (83.5%) pregnant mothers reported no vigorous activity; after adjustment for covariates, this was more common among mothers of children with Social Responsiveness Scale T-scores >75 compared with mothers of children with lower T-scores (adjusted odds ratio (95% confidence interval) = 2.94 (1.11, 7.78)). Among parents caring for an autistic child before and during a subsequent pregnancy, physical activity was lower than recommended. Family-based interventions may be necessary to help support physical activity levels. Lay Abstract Parents of autistic children may have limited time and resources to participate in physical activity, a key aspect of health. Previous studies have been small and included mostly mothers, rather than fathers. No studies have examined physical activity in these parents during another pregnancy, when physical activity is especially important for maternal and fetal health. We aimed to fill this gap by examining physical activity levels among mothers and fathers caring for an autistic child before and during a subsequent pregnancy. We used data from a study which followed pregnant individuals who already had a child with autism. We asked mothers and fathers to report their levels of moderate and vigorous physical activity. We found that mothers and fathers of autistic children reported lower physical activity levels than the national average and were unlikely to meet Physical Activity Guidelines for Americans. Pregnant mothers were the least likely to participate in physical activity, particularly if their autistic child scored highly on a measure of autistic traits. Given that parental physical activity has benefits for parents and children, family-based interventions may be needed to help support parents’ physical activity levels.