bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Scholars Researching Black British Histories (mid-Eighteenth to mid-Nineteenth Centuries)
Authors: Warren Kristy , Gilmore Annabelle , Marché Montaz 
Published: October 2024

AbstractRecent years have seen a vast expansion of scholarly interest in eighteenth- and nineteenth-century Black British histories, and increasing calls to support the work of early-career scholars (ECRs) in this field. Yet ECRs continue to face several specific challenges in conducting this crucial research. This section consists of a brief introduction and two case studies based on the research and experiences of Ph.D. students Annabelle Gilmore and Montaz Marché. Gilmore aims to amplify the connections between the lives and labour of enslaved people on plantations in Jamaica and the wealth and art collection of William Thomas Beckford, now held at Charlecote Park, from the mid-eighteenth to the mid-nineteenth centuries. Marché seeks to trace the presence of Black women in eighteenth-century London, drawing on archival documents that provide traces of who these women may have been, and confronting the limitations of the traditional archive. Together, these pieces offer a glimpse into how these ECRs are positioning themselves within the historiography as well as considering how they hope to contribute to the field.
Analyzing the seasonality of tuberculosis case notifications in the UK, 2000–2018
Authors: Glaser Lisa , Harris Ross , Mohiyuddin Tehreem , Davidson Jennifer A. , Cox Sharon , Campbell Colin N. J. 
Published: October 2024

Abstract
Globally, there is seasonal variation in tuberculosis (TB) incidence, yet the biological and behavioural or social factors driving TB seasonality differ across countries. Understanding season-specific risk factors that may be specific to the UK could help shape future decision-making for TB control. We conducted a time-series analysis using data from 152,424 UK TB notifications between 2000 and 2018. Notifications were aggregated by year, month, and socio-demographic covariates, and negative binomial regression models fitted to the aggregate data. For each covariate, we calculated the size of the seasonal effect as the incidence risk ratio (IRR) for the peak versus the trough months within the year and the timing of the peak, whilst accounting for the overall trend. There was strong evidence for seasonality (p < 0.0001) with an IRR of 1.27 (95% CI 1.23–1.30). The peak was estimated to occur at the beginning of May. Significant differences in seasonal amplitude were identified across age groups, ethnicity, site of disease, latitude and, for those born abroad, time since entry to the UK. The smaller amplitude in older adults, and greater amplitude among South Asians and people who recently entered the UK may indicate the role of latent TB reactivation and vitamin D deficiency in driving seasonality.
The Definition of ‘Covered Entities’ under the GPA: The General Scope and Escape Conditions
Authors: Lian Wenyi 
Published: October 2024

AbstractThe WTO Government Procurement Agreement (GPA) does not legally define what entities should be covered by the Agreement. However, its member Parties list their ‘covered entities’ in a series of schedules. The list approach has complicated accession negotiations and discourages Parties from providing a ‘wider’ range of entity coverage. Moreover, the list approach raises some tensions and a lack of legal certainty, especially concerning those that are not strictly ‘government entities’, such as State-owned enterprises (SOEs). This problem is exacerbated in the case of modern SOEs in developing countries, many of which can bear both public and private features. Given these conditions, the author proposes a definition of ‘covered entities’ to facilitate accession negotiations and the future expansion of the GPA. The proposal is based on a comparative study of the GPA and the EU public procurement regulations. It develops a framework by which all publicly controlled entities are presumably covered by the GPA. Nevertheless, Parties can rebut GPA obligations by proving that an entity competes with other commercial entities under normal market conditions.
Seasonal Early Warning of Impacts of Harmful Algal Blooms on Farmed Shellfish in Coastal Waters of Scotland
Authors: Stoner O. , Economou T. , Brown A. R. 
Published: October 2024

AbstractHarmful Algal Blooms (HABs) can produce phycotoxins that accumulate in shellfish and subsequently poison aquatic predators and human consumers, potentially causing significant economic impacts to the shellfish aquaculture industry. HAB events are challenging to foresee as they are driven by complex inter‐annual and seasonal changes in physical, chemical and biological factors. Accounting for these environmental drivers and their interactions in statistical models allows for the development of HAB early warning systems. Typically, these have a forecasting horizon of 1–2 weeks, allowing shellfish businesses and regulators to increase monitoring intensity and take evasive action, including harvesting suspensions to protect consumer health. However, there is critical need for longer‐term predictions of risk, to enable more proactive mitigation, business planning, harvest scheduling and supply chain management. We present a statistical framework for providing seasonal‐scale early warnings of the occurrence and impacts of Dinophysis spp. HABs on shellfish aquaculture in Scotland, UK. We use penalized smooth functions of winter‐spring daily sea surface temperature to predict the severity and impact of ensuing summer blooms, including the percentage of toxicity measurements exceeding the harvesting closure threshold, as well as the anticipated start, end, and overall duration of closures. We illustrate the application of this framework to two Scottish aquaculture regions: One with a high spatial concentration of harvesting sites (Shetland) and one with more dispersed sites (West Scotland and the Hebrides). Through a comprehensive yearly prediction experiment, we demonstrate considerable skill in predicting the impact of unseen HAB seasons at a regional level.
Blowin’ in the Wind: Mapping the Dispersion of Metal(loid)s From Atacama Mining
Authors: Zanetta‐Colombo Nicolás C. , Manzano Carlos A. , Brombierstäudl Dagmar , Fleming Zoë L. , Gayo Eugenia M. , Rubinos David A. , Jerez Óscar , Valdés Jorge , Prieto Manuel , Nüsser Marcus 
Published: October 2024

AbstractThe Atacama Desert’s naturally elevated metal(loid)s pose a unique challenge for assessing the environmental impact of mining, particularly for indigenous communities residing in these areas. This study investigates how copper mining influences the dispersion of these elements in the wind‐transportable fraction (<75 μm) of surface sediments across an 80 km radius. We employed a multi‐pronged approach, utilizing spatial modeling to map element distributions, exponential decay analysis to quantify concentration decline with distance, regime shift modeling to identify dispersion pattern variations, and pollution assessment to evaluate impact. Our results reveal significant mining‐driven increases in surface concentrations of copper (Cu), molybdenum (Mo), and arsenic (As). Notably, within the first 20 km, concentrations peaked at 1,016 mg kg⁻1 for Cu, 31 mg kg⁻1 for Mo, and a remarkable 165 mg kg⁻1 for As. Cu and Mo displayed significant dispersion, extending up to 50 km from the source. However, As exhibited the most extensive reach, traveling up to 70 km downwind, highlighting the far‐reaching ecological footprint of mining operations. Mineralogical analyses corroborated these findings, identifying mining‐related minerals in surface sediments far beyond the immediate mining area. Although pollution indices based on the proposed Local Geochemical Background reveal significant contamination across the study area, establishing accurate pre‐industrial baseline values is essential for a more reliable assessment. This study challenges the concept of “natural pollution” by demonstrating that human activities exacerbate baseline metal(loid)s levels. Expanding monitoring protocols is imperative to comprehensively assess the combined effects of multiple emission sources, including mining and natural processes, in safeguarding environmental and human health for future generations.
Wildfire Particulates Enhance Phytoplankton Growth and Alter Communities in the South China Sea Under Wind‐Driven Upwelling
Authors: Peng Runqian , Chen Xiaoyan , Wu Qiuyun , Yan Zhaoqian , Fu Yichen , Qin Bo , Hao Ruoxing , Yu Kefu 
Published: October 2024

AbstractExtreme wildfire events and cyclones are on the rise across tropical regions in response to climate change. Despite assumptions about their impact on phytoplankton through nutrient supplies, field evidence is lacking, and their combined effects remain unclear. In an on‐site microcosm experiment conducted in the Xisha Islands, South China Sea (SCS) after Typhoon Noru, we observed enhanced phytoplankton growth in response to exposure to total suspended particulates (TSP) from wildfires (2 mg/L and 6 mg/L) under wind‐driven upwelling conditions. Upwelled nutrients had a limited effect on Chl‐a concentration due to phosphate depletion, by contrast, wildfire TSP contributed nutrients enriched in nitrogen and phosphate, resulting in a 3.30–5.61‐fold increase in Chl‐a. However, upwelled nutrients increased the diatom‐to‐dinoflagellate ratio from the initial 11.0 to 12.7, TSP at low and high levels reduced the ratio to 0.3–0.8 and significantly altered the communities, with 61.8% of species, including two dominant diatoms, negatively correlated with N and/or P supplies. Species diversity declined significantly at high TSP levels. These findings suggest that enhanced primary productivity by wildfires may come at the cost of an altered phytoplankton community. This field study improves understanding of the effects of simultaneous occurrences of multiple extreme climate events on marine ecosystems.
Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids via low-coherence holotomography
Authors: Lee Mahn Jae , Lee Jaehyeok , Ha Jeongmin , Kim Geon , Kim Hye-Jin , Lee Sumin , Koo Bon-Kyoung , Park YongKeun 
Published: October 2024

AbstractOrganoids, which are miniature in vitro versions of organs, possess significant potential for studying human diseases and elucidating their underlying mechanisms. Live imaging techniques play a crucial role in organoid research and contribute to elucidating the complex structure and dynamic biological phenomena of organoids. However, live, unlabeled high-resolution imaging of native organoids is challenging, primarily owing to the complexities of sample handling and optical scattering inherent in three-dimensional (3D) structures. Additionally, conventional imaging methods fail to capture the real-time dynamic processes of growing organoids. In this study, we introduce low-coherence holotomography as an advanced, label-free, quantitative imaging modality designed to overcome several technical obstacles for long-term live imaging of 3D organoids. We demonstrate the efficacy of low-coherence holotomography by capturing high-resolution morphological details and dynamic activities within mouse small intestinal organoids at subcellular resolution. Moreover, our approach facilitates the distinction between viable and nonviable organoids, significantly enhancing its utility in organoid-based research. This advancement underscores the critical role of live imaging in organoid studies, offering a more comprehensive understanding of these complex systems.
Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels
Authors: Davaanyam Dashdulam , Seol Song-I , Oh Sang-A , Lee Hahnbi , Lee Ja-Kyeong 
Published: October 2024

AbstractWe previously reported that high mobility group box 1 (HMGB1), a danger-associated molecular pattern (DAMP), increases intracellular iron levels in the postischemic brain by upregulating hepcidin, a key regulator of iron homeostasis, triggering ferroptosis. Since hepatocytes are the primary cells that produce hepcidin and control systemic iron levels, we investigated whether cerebral ischemia induces hepcidin upregulation in hepatocytes. Following middle cerebral artery occlusion (MCAO) in a rodent model, significant liver injury was observed. This injury was evidenced by significantly elevated Eckhoff’s scores and increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Additionally, total iron levels were significantly elevated in the liver, with intracellular iron accumulation detected in hepatocytes. Hepcidin expression in the liver, which is primarily localized in hepatocytes, increased significantly starting at 3 h after MCAO and continued to increase rapidly, reaching a peak at 24 h. Interestingly, HMGB1 levels in the liver were also significantly elevated after MCAO, with the disulfide form of HMGB1 being the major subtype. In vitro experiments using AML12 hepatocytes showed that recombinant disulfide HMGB1 significantly upregulated hepcidin expression in a Toll-like receptor 4 (TLR4)- and RAGE-dependent manner. Furthermore, treatment with a ROS scavenger and a peptide HMGB1 antagonist revealed that both ROS generation and HMGB1 induction contributed to hepatocyte activation and liver damage following MCAO–reperfusion. In conclusion, this study revealed that cerebral ischemia triggers hepatocyte activation and liver injury. HMGB1 potently induces hepcidin not only in the brain but also in the liver, thereby influencing systemic iron homeostasis following ischemic stroke.
Cbx4 SUMOylates BRD4 to regulate the expression of inflammatory cytokines in post-traumatic osteoarthritis
Authors: Zhou Ding , Tian Jia-Ming , Li Zi , Huang Jun 
Published: October 2024

AbstractBrominated domain protein 4 (BRD4) is a chromatin reader known to exacerbate the inflammatory response in post-traumatic osteoarthritis (PTOA) by controlling the expression of inflammatory cytokines. However, the extent to which this regulatory effect is altered after BRD4 translation remains largely unknown. In this study, we showed that the E3 SUMO protein ligase CBX4 (Cbx4) is involved in the SUMO modification of BRD4 to affect its ability to control the expression of the proinflammatory genes IL-1β, TNF-α, and IL-6 in synovial fibroblasts. Specifically, Cbx4-mediated SUMOylation of K1111 lysine residues prevents the degradation of BRD4, thereby activating the transcriptional activities of the IL-1β, TNF-α and IL-6 genes, which depend on BRD4. SUMOylated BRD4 also recruits the multifunctional methyltransferase subunit TRM112-like protein (TRMT112) to further promote the processing of proinflammatory gene transcripts to eventually increase their expression. In vivo, treatment of PTOA with a Cbx4 inhibitor in rats was comparable to treatment with BRD4 inhibitors, indicating the importance of SUMOylation in controlling BRD4 to alleviate PTOA. Overall, this study is the first to identify Cbx4 as the enzyme responsible for the SUMO modification of BRD4 and highlights the central role of the Cbx4-BRD4 axis in exacerbating PTOA from the perspective of inflammation.
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection
Authors: Yi Jia-xuan , Sun Ze-yu , Liu Peng , Wang Yu-hang , Liu Hui , Lv Qing-yu , Kong De-cong , Huang Wen-hua , Ren Yu-hao , Li Qian , Jiang Yong-qiang , Li Jing , Jiang Hua 
Published: October 2024

AbstractIL-1β represents an important inflammatory factor involved in the host response against GBS infection. Prior research has suggested a potential involvement of IL-1β in the process of ferroptosis. However, the relationship between IL-1β and ferroptosis in the context of anti-GBS infection remains uncertain. This research demonstrates that the occurrence of ferroptosis is essential for the host’s defense against GBS infection in a mouse model of abdominal infection, with peritoneal macrophages identified as the primary cells undergoing ferroptosis. Further research indicates that IL-1β induces lipid oxidation in macrophages through the upregulation of pathways related to lipid oxidation. Concurrently, IL-1β is not only involved in the initiation of ferroptosis in macrophages, but its production is intricately linked to the onset of ferroptosis. Ultimately, we posit that ferroptosis acts as a crucial initiating factor in the host response to GBS infection, with IL-1β playing a significant role in the resistance to infection by serving as a key inducer of ferroptosis.
The magic, memory, and curiosity fMRI dataset of people viewing magic tricks
Authors: Meliss Stefanie , Pascua-Martin Cristina , Skipper Jeremy I. , Murayama Kou 
Published: October 2024

AbstractVideos of magic tricks offer lots of opportunities to study the human mind. They violate the expectations of the viewer, causing prediction errors, misdirect attention, and elicit epistemic emotions. Herein we describe and share the Magic, Memory, and Curiosity (MMC) Dataset where 50 participants watched 36 magic tricks filmed and edited specifically for functional magnetic imaging (fMRI) experiments. The MMC Dataset includes a contextual incentive manipulation, curiosity ratings for the magic tricks, and incidental memory performance tested a week later. We additionally measured individual differences in working memory and constructs relevant to motivated learning. fMRI data were acquired before, during, and after learning. We show that both behavioural and fMRI data are of high quality, as indicated by basic validation analysis, i.e., variance decomposition as well as intersubject correlation and seed-based functional connectivity, respectively. The richness and complexity of the MMC Dataset will allow researchers to explore dynamic cognitive and motivational processes from various angles during task and rest.
Assessing vaccinated persons’ intention to take the COVID-19 boosters using a combined theoretical framework: an online survey in Egypt
Authors: El Tantawi Maha , Elwan Amira H. , Hassan Reham , Mohamed Nesreen Farouk , Elsheikh Enas I. , Hassan Heba Ali , Abdelwahab Sayed F. 
Published: October 2024

AbstractVaccines, like the Corona Virus Disease-2019 (COVID-19) vaccines, can control diseases, but vaccine hesitancy reduces their use. It is important to assess the intention to use COVID-19 vaccines boosters and the determinants of this intention to help in developing programs to promote the uptake of boosters. An online survey collected data from adults in Egypt between March and June 2022 using a questionnaire that assessed demographic characteristics, and constructs of the Theory of Planned Behaviour (TPB) and the Health Belief Model (HBM). The survey was uploaded to SurveyMonkey and the links were posted on social media platforms. Binary regression analysis was used and the dependent variable was intention to use boosters of COVID-19 vaccines. The independent variables were indicators of the HBM including perceived susceptibility to COVID-19 infection (medical history) and possibility of disease prevention (awareness of the availability of types of COVID-19 vaccines); and indicators of the TPB including attitude toward COVID-19 vaccines (that they are harmful, that they may lead to death and confidence in locally and foreign manufactured vaccines), perceived norms (the percentage of vaccinated persons in one’s circle) and perceived control over booster uptake (presence of government mandates for COVID-19 vaccination). The confounders were sociodemographic factors (age, sex, education, and place of residence). Complete responses were available from 1113 out of 1401 participants (79.4%), with mean (SD) age = 25 (9.5) years, of whom, 66.7% (n = 742) were females and 68.6% (n = 764) were university students. About 39.4% and 31.2% indicated that they would get or would definitely get the booster dose of the COVID-19 vaccines. In multiple regression, intention to use a booster dose was significantly related to not agreeing (AOR = 4.87, P < 0.001) or not agreeing at all (AOR = 8.46, P = 0.001) that vaccines are harmful and to having no confidence (AOR = 0.21, P < 0.001) or no confidence at all (AOR = 0.14, P < 0.001) in foreign-manufactured vaccines. Most university-educated Egyptians in the study intended to take the COVID-19 vaccine booster dose and this intention was associated with attitude toward the harm of the vaccine and confidence in foreign-manufactured vaccines. Awareness campaigns are needed to counteract misinformation and promote booster dose uptake.
Complex trade-offs in a dual-target visual search task are indexed by lateralised ERP components
Authors: Henare Dion T. , Tünnermann Jan , Wagner Ilja , Schütz Alexander C. , Schubö Anna 
Published: October 2024

AbstractIn everyday tasks, the choices we make incorporate complex trade-offs between conflicting factors that affect how we will achieve our goals. Previous experimental research has used dual-target visual search to determine how people flexibly adjust their behaviour and make choices that optimise their decisions. In this experiment, we leveraged a visual search task that incorporates complex trade-offs, and electroencephalography (EEG), to understand how neural mechanisms of selective attention contribute to choice behaviour in these tasks. On each trial, participants could choose to respond to the gap location on either of two possible targets. Each target was colour coded such that colour indicated which of the two had the easier gap discrimination. Orthogonally, we manipulated the set size of coloured distractors to modulate how efficiently each target could be found. As a result, optimised task performance required participants to trade-off conflicts between the ease of finding a target given the current set size, and the ease of making its associated gap discrimination. Our results confirm that participants are able to flexibly adjust their behaviour, and trade-off these two factors to maintain their response speed and accuracy. Additionally, the N2pc and SPCN components elicited by search displays could reliably predict the choice that participants would ultimately make on a given trial. These results suggest that initial attentional processes may help to determine the choice participants make, highlighting the central role that attention may play in optimising performance on complex tasks.