bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accessibility of Finding Tuberculosis Case Actively, Separate Safely and Treat Effectively (FAST) Strategy for Early Detection of Suspected and Symptomatic Tuberculosis Patients: A Hospital Based Quantitative Study
Authors: Shrestha Merina , Singh Priyadarshini Shah , Rana Dilasha , Jayswal Aakash 
Published: September 2024

Introduction: Tuberculosis is a contagious disease which has always been a challenge over the course of human history. It is known to spread mostly from persons with undiagnosed and suspected tuberculosis cases. Diagnosing tuberculosis in an early stage with effective treatment is one of the best ways to reduce the burden of tuberculosis. Finding cases Actively, Separate safely and Treat effectively (FAST) Strategy in Nepal, is a rapid diagnostic tool for rapid tuberculosis case detection.
Aims: To access tuberculosis case Actively, Separate safely and Treat effectively (FAST) strategy for suspected and symptomatic tuberculosis patients coming to the hospital for early case detection and also to identify patient’s health care behaviour, technical barrier during surveillance.
Methods: An observational quantitative study of active cough surveillance was carried at an entry point of FAST corner of Nepalgunj Medical College Teaching Hospital, Banke from April 2023 to December 2023. Scrutinized data was obtained by purposive sampling method with sample size 128 from FAST corner.
Results: Maximum cases belonged to the aged group 65 and above having lower middle to lower socioeconomic status. Most of them were from joint family with contact history of tuberculosis in 35 (27.3) % of total cases. Out of total cases, 72 (56.25) % were confirmed with tuberculosis. Among those confirmed tuberculosis cases, multi drug resistance TB was found in 6 (4.7) %. Uses of mask was found significant (P< 0.05) in our study although number of these health care behaviour were less appropriate. Pneumonia was a significant association 17 (P = 0.004) with tuberculosis patient. Insufficient volunteers, and limited Gene xpert machine were major barriers to implement FAST strategy screening in Hospital.
Conclusion: FAST strategy is feasible tool in high tuberculosis burden healthcare settings in Nepal. However, the technical and behavioral factors should be managed to ensure an effective approach.
Il mistero dell’Incarnazione nelle "Enarrationes in Psalmos" di Sant’Agostino
Authors: Turzyński Piotr 
Published: September 2024

L’articolo presenta l’importanza del tema dell’Incarnazione nel commento di S. Agostino ai Salmi. Secondo il Vescovo di Ippona, il Mistero dell’Incarnazione è uno dei momenti chiave della storia della salvezza. Agostino, negli scritti dei filosofi antichi, non ha trovato un modo in cui l’uomo potesse raggiungere il mondo divino a cui aspira. Tuttavia, il cristianesimo gli ha indicato la via dell’umiltà (via humilitatis) nell’Incarnazione. In Cristo, Dio assume la condizione umana e, senza perdere nulla della sua divinità, introduce l’uomo nel mondo divino dell’eternità. Agostino è convinto che l’umiltà del Figlio di Dio nel mistero dell’Incarnazione fa dell’umiltà di Dio il nucleo della fede cristiana. E la stessa categoria dell’umiltà non ha solo una dimensione morale ma anche filosofica. In virtù dell’Incarnazione, Cristo diventa rappresentante degli uomini e il sacerdote che offre se stesso come l’offerta a Dio Padre. E tutta la Sua opera salvifica costituisce l’unità e ha il suo fondamento, senso, peso e significato proprio nel mistero dell’Incarnazione.
Agostino spiega l’Incarnazione in modo biblico e figurato. Per lui Cristo in quanto Dio è la Patria da cui l’uomo è venuto e verso la quale è diretto, ed in quanto uomo è la Via lungo la quale andiamo per raggiungere la meta. In virtù dell’Incarnazione, il tempo umano acquista un carattere propositivo e tende al suo compimento nell’eternità.
РОЗВИТОК МЕДІАГРАМОТНОСТІ УЧНІВ ПІД ЧАС ВИВЧЕННЯ ІНФОРМАТИКИ
Authors: Федоренко Олена , Фесенко Анастасія , Зима Ганна 
Published: September 2024

У статті розглядається актуальна проблема розвитку медіаграмотності учнів середньої школи в умовах інформаційного суспільства. Обґрунтовується важливість розвитку навичок критичного сприйняття, аналізу та створення медіаконтенту для підготовки школярів до безпечної та ефективної взаємодії з різними типами медіа. Проаналізовано потенціал уроків інформатики для впровадження медіаосвіти через виконання практичних завдань із пошуку, перевірки та представлення інформації, дотримання авторського права, безпечної онлайн поведінки та створення власних медіапродуктів.
BEM-ESTAR EMOCIONAL
Authors: Garces Solange Beatriz Billig , Lauxen Sirlei de Lourdes , Melo Dulcilene Alves de , Souza Lucimara Rocha de , Silveira Adriana da Silva , Brutti Tiago Anderson 
Published: September 2024

Este artigo visa expor o trabalho desenvolvido no Bairro Vida Nova II em Cruz Alta, Rio Grande do Sul, por meio do projeto Mentes Sábias, que foi idealizado para cultivar o bem-estar emocional em crianças e adolescentes por meio das práticas de mindfulness. Essa iniciativa é resultado de uma colaboração entre estudantes de graduação e pós-graduação da Universidade de Cruz Alta/RS e se desdobrou em três encontros presenciais, com 40 crianças e adolescentes. O foco da atividade eram exercícios de respiração e técnicas de relaxamento, escolhidos para munir os participantes com habilidades práticas, visando uma gestão eficaz das emoções e estresse cotidiano. A metodologia adotada para o desenvolvimento dessa atividade envolveu uma abordagem participativa de pesquisa-ação para o desenvolvimento humano e social, permitindo que os jovens experimentassem e refletissem sobre as práticas de mindfulness, facilitando a internalização de estratégias para regular as emoções, criando um espaço de bem-estar emocional envolvendo relacionamentos interpessoais satisfatórios no cotidiano. Este projeto faz parte do Laboratório da Vida Real (Reallabor) e alinha-se com os objetivos do Laboratório de Estudos e Pesquisas em Práticas Interdisciplinares, ambos do Programa de Pós-Graduação em Práticas Socioculturais e Desenvolvimento Social (PPGPSDS) da Universidade de Cruz Alta/RS, os quais visam integrar a comunidade acadêmica e local em esforços conjuntos de desenvolvimento social e humano, de maneira interdisciplinar. Assim, Mentes Sábias serve como exemplo de como práticas integrativas e colaborativas podem fomentar o crescimento individual e coletivo.
تاثر تمرينات الاسترخاء العقلي - بدني في مهارة التهديف من المتابعة بكرة السلة للاعبين
Authors: Asst. Prof. Dr. Nidal Obaid Hamza  , Asst. Lect. Fadia Ismail Jabr  
Published: September 2024

كرة السلة من الالعاب الفرقية التي تسهم فيها عمليات الاندماج المتكامل بين العقل (الذهن) والحركات البدنية المهارية لتصل باللاعب الى اقصى ما يمكن من الاتقان والافادة من طاقة الحركية والبدنية في الاداء المهاري وان من الاسس المهمة في التدريب الرياضي ان يؤدي الرياضي السلسلة المهارية كاملةً وبذلك يكون بحاجة الى الانتباه والتصور والاسترخاء والاستيعاب لمعرفة جوانب اداء المهارة والتمرين عليها مهاريا .
وهدفت الدراسة الى التعرف على تأثير التمرينات بالاسترخاء العقلي والعضلي والتي أعدتها الباحثتان على عينة من لاعبي نادي الحلة الرياضة بكرة السلة والبالغ عددهم (20) لاعب تم تقسميهم الى مجموعتين ضابطة وتجريبية بواقع 10 لاعبين لكل مجموعة وتم تطبيق تمرينات الاسترخاء العقلي لمدة 4 أسابيع بواقع 3 وحدات تدريبية بالأسبوع أي لمدة 12 وحدة تدريبية تراوحت مدة الوحدة التدريبية بالاسترخاء العضلي والعقلي بين 25-28 دقيقة وتم اجراء الاختبارات القبلية ومن ثم اعداد منهاج التمرينات بالاسترخاء العقلي والعضلي وبعد الانتهاء من مدة التمرينات تم اجراء الاختبارات البعدية وتفريغ البيانات ومن ثم تم معالجتها باستخدام الحقيبة الإحصائية spss للحصول على النتائج البحثية ومناقشتها وقد استنتجت الباحثتين بان التمرينات المعدة بالاسترخاء العقلي لها تأثير إيجابي في تطوير مهارة التهديف من المتابعة
كما ان المجموعة التجريبية تفوقت في المهارة على حساب المجموعة الضابطة واوعزت الباحثتين ذلك الى تطبيق اللاعبين للتمرينات الاسترخاء العضلي والعقلي
كما اوصت الباحثتين بضرورة استخدام تمرينات الاسترخاء المعدة في تطوير المهارات الأساسية بكرة السلة كونها اثبتت فاعليتها في هذه الدراسة .
PENGARUH CORPORATE GOVERNANCE TERHADAP MANAJEMEN LABA (Studi Empiris Pada Perusahaan Manufaktur yang Terdaftar Di Bursa Efek Indonesia)
Authors: Ayu Novianti  , Fenny Marietza  
Published: September 2024

This study aims to examine the effect of corporate governance on earnings management. The population of this study is all manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the 2014-2017 period. The sample is determined based on the philosophy of portisivism, so that a sample of 82 companies was obtained with a total of 306 observations. Data analysis techniques using multiple linear regression analysis with earnings management as the dependent variable, corporate governance as an independent variable. Processing data using SPSS version 22.0 for Windows. The results show that corporate governance has a negative effect on earnings management
For the next researcher in order to expand or add research samples to the financial company sector or all companies listed on the Indonesian stock exchange and add to the period of research observation
Association between rest-activity rhythm and diabetic retinopathy among US middle-age and older diabetic adults
Authors: Wang Zhijie , Wu Mengai , Li Haidong , Zheng Bin 
Published: September 2024

BackgroundThe disruption of circadian rhythm has been reported to aggravate the progression of diabetic retinopathy (DR). Rest-activity rhythm (RAR) is a widely used method for measuring individual circadian time influencing behavior. In this study, we sought to explore the potential association between RAR and the risk of DR.MethodsDiabetic participants aged over 40 from 2011-2014 National Health and Nutrition Examination Survey (NHANES) were enrolled. Data from the wearable device ActiGraph GT3X was used to generate RAR metrics, including interdaily stability (IS), intradaily variability (IV), most active 10-hour period (M10), least active 5-hour period (L5), and Relative amplitude (RA). Weighted multivariable logistic regression analysis and restricted cubic spline analysis were conducted to examine the association between RAR metrics and DR risk. Sensitivity analysis was also conducted to examine the robustness of the findings. An unsupervised K-means clustering analysis was conducted to identify patterns in IV and M10.ResultsA total of 1,096 diabetic participants were enrolled, with a DR prevalence of 20.53%. The mean age of participants was 62.3 years, with 49.57% being male. After adjusting covariates, IV was positively associated with DR (β: 3.527, 95%CI: 1.371-9.073). Compared with the lowest quintile of IV, the highest quintile of IV had 136% higher odds of DR. In contrast, M10 was negatively associated with DR (β: 0.902, 95%CI: 0.828-0.982), with participants in the highest M10 quintile showing 48.8% lower odds of DR. Restricted cubic spline analysis confirmed that these associations were linear. Meanwhile, sensitivity analysis confirmed the robustness. K-means clustering identified three distinct clusters, with participants in Cluster C (high-IV, low-M10) had a significantly higher risk of DR comparing with Cluster A (low-IV, high-M10).ConclusionA more fragmented rhythm and lower peak activity level might be associated with an increased risk of DR. These findings indicate that maintaining a more rhythmic sleep-activity behavior might mitigate the development of DR. Further research is necessary to establish causality and understand the underlying mechanisms, and focus on whether interventions designed to enhance daily rhythm stability and increase diurnal activity level can effectively mitigate the risk of progression of DR.
Enhanced computed tomography radiomics predicts solute carrier family 7, member 11 in head and neck squamous cell carcinoma
Authors: Lv Jilian , Meng Xiangze , Li Yuanyuan , Zhang Rui , Zhao Yuan , Yang Xi , Wang Fang , Wang Xinbin 
Published: September 2024

IntroductionTraditional prognostic indicators for head and neck squamous cell carcinoma (HNSCC), such as clinicopathological features, human papillomavirus status, and imaging examinations, often lack precision in guiding medical therapy. Therefore, discovering novel tumor biomarkers that can accurately assess prognosis and aid in personalized medical treatment for HNSCC is critical. Solute carrier family 7, member 11 (SLC7A11), is implicated in ferroptosis, and various malignant tumor therapies regulate its expression. However, the mechanisms regulating SLC7A11 expression, the transporter activity, and its specific role in controlling ferroptosis in cancer cells remain unknown. Thus, in this study, we aimed to develop an improved computed tomography (CT) radiomics model that could predict SLC7A11 expression in patients with HNSCC.MethodsWe used patient genomic data and corresponding augmented CT images for prognostic analysis and building models. Further, we investigated the potential molecular mechanisms underlying SLC7A11 expression in the immune microenvironment. Our radiomics model successfully predicted SLC7A11 mRNA expression in HNSCC tissues and elucidated its association with relevant genes and prognostic outcomes.ResultsSLC7A11 expression level was high within tumor tissues and was connected to the infiltration of eosinophil, CD8+ T-cell, and macrophages, which was associated with poor overall survival. Our models demonstrated robust predictive power. The distribution of radiomics scores (RAD scores) within the training and validation sets was markedly different between the high- and low-expression groups of SLC7A11.ConclusionSLC7A11 is likely an important factor in the prognosis of HNSCC. SLC7A11 expression can be predicted effectively and reliably by radiomics models based on enhanced CT.
Association study reveals a susceptibility locus with male pattern baldness in the Han Chinese population
Authors: Li Yang , Huang He , Liang Bo , Xiao Feng-Li , Zhou Fu-Sheng , Zheng Xiao-Dong , Yang Sen , Zhang Xue-Jun 
Published: September 2024

IntroductionMale pattern baldness (MPB), also known as androgenetic alopecia, represents the most prevalent form of progressive hair loss in humans. It is characterized by a distinctive pattern of hair loss progression from the scalp; however, its underlying mechanism remains elusive and is influenced by hereditary, immune, and environmental factors. Genome-wide association studies (GWASs) have uncovered numerous risk genes/loci among European individuals with MPB. However, the validation of these susceptibility genes/loci within Han Chinese men remains largely unexplored. The aim of this study was to investigate whether the 71 susceptibility loci identified in a recent GWAS among European men also confer risk for MPB in Chinese men.MethodsForty-seven single nucleotide polymorphisms (SNPs) previously reported in GWASs of MPB were selected and genotyped in independent individuals comprising 499 Han Chinese cases and 1,489 controls using the Sequenom MassArray system. After stringent quality control measures, 25 SNPs were subjected to statistical analyses. Cochran–Armitage trend test was used to evaluate the association between SNPs and disease susceptibility. To address multiple tests, Bonferroni correction was conducted, setting the threshold for statistical significance at a p-value &lt;2 × 10−3 (0.05/25).ResultsThe rs13405699 SNP located at 2q31.1 exhibited a significant association with MPB in Han Chinese men (p = 4.84 × 10−5, OR = 1.37, 95% CI: 1.18–1.59). Moreover, the difference in rs13405699 genotype distribution between MPB cases and controls was statistically significant (p = 7.00 × 10−5). Genotype-based association analysis suggested that the recessive model provided the best fit for the rs13405699 polymorphism.ConclusionThis study represents the first confirmation of the association between the rs13405699 SNP at 2q31.1 and MPB within the Han Chinese population, thereby enhancing our understanding of the genetic underpinnings of MPB.
Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes
Authors: Kakabadse Dimitri , Chen Dawei , Fishman Sigal , Weinstein-Marom Hadas , Davies Joanne , Wen Li , Gross Gideon , Wong F. Susan 
Published: September 2024

IntroductionIn this study, we report a novel therapeutic approach redirecting antigen-specific CD4+ T cells recognizing a hybrid insulin peptide (BDC2.5 T cell receptor (TCR) transgenic CD4+ T cells) to attract and suppress islet-specific CD8+ T cells T cells in the non-obese diabetic (NOD) mouse model, and prevent the development of autoimmune diabetes.MethodsPurified BDC2.5 CD4+ T cells were induced to differentiate into regulatory T cells (Tregs). The Tregs were then electroporated with mRNA encoding chimeric human β2 microglobulin (hβ2m) covalently linked to insulin B chain amino acids 15-23 (designated INS-eTreg) or islet-specific glucose-6-phosphatase related protein (IGRP) peptide 206-214 (designated IGRP-eTreg). Immunoregulatory functions of these engineered regulatory T cells (eTregs) were tested by in vitro assays and in vivo co-transfer experiments with β-cell-antigen-specific CD8+ T cells in NOD.Scid mice or by adoptive transfer into young, pre-diabetic NOD mice.ResultsThese eTregs were phenotyped by flow cytometry, and shown to have high expression of FoxP3, as well as other markers of Treg function, including IL-10. They suppressed polyclonal CD4+ T cells and antigen-specific CD8+ T cells (recognizing insulin or IGRP), decreasing proliferation and increasing exhaustion and regulatory markers in vitro. In vivo, eTregs reduced diabetes development in co-transfer experiments with pathogenic antigen-specific CD8+ T cells (INS-CD8+ or IGRP-CD8+ cells) into NOD.Scid mice. Finally, when the eTreg were injected into young NOD mice, they reduced insulitis and prevented spontaneous diabetes in the recipient mice.ConclusionOur results suggest a novel therapeutic strategy to protect NOD mice by targeting antigen-specific cytotoxic CD8+ T cells, using redirected antigen-specific CD4+ Treg cells, to suppress autoimmune diabetes. This may suggest an innovative therapy for protection of people at risk of development of type 1 diabetes.
Association of sleep quality with cognitive dysfunction in middle-aged and elderly adults: a cross-sectional study in China
Authors: Jiang Mengyang , Liu Yang , Wang Xin , Liu Yuhe , Deng Xuan , Zhang Xiaoyu , Wang Baoguo 
Published: September 2024

ObjectivesSleep is an indispensable part of human health, which can help us to restore physical strength, enhance immunity and maintain nervous system stability. The relationship between sleep quality and cognitive dysfunction is unclear, especially at the community population level. This study aims to explore the association between sleep quality and cognitive dysfunction.MethodsA total of 5,224 community residents were enrolled in this cross-sectional study. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). Sleep quality was assessed by the multidimensional sleep questionnaire. Multivariate logistic regression was used to analyze the association between sleep quality and cognitive dysfunction. The adjusted models took into account relevant demographic, clinical, and sleep variables.ResultsA total of 3,106 participants were enrolled in this study, of whom 463 (15%) had cognitive dysfunction. Total sleep duration, staying up, sleep latency, number of awakenings, and history of sleep medications were associated with cognitive dysfunction in unadjusted models, and these effects were consistent after adjustment. First, those who slept 6–7.9 h per day (OR = 0.57, 95% CI 0.40 to 0.80, p = 0.001) had a lower risk for cognitive dysfunction compared to those who slept less than 6 h per day. Second, participants who stayed up more than 10 times over the 3 months (OR = 1.90, 95% CI 1.20 to 3.00, p = 0.006) were more likely to suffer cognitive dysfunction than those who never stayed up. Third, we also found that participants with sleep latencies of 16–30 min were less likely to experience cognitive dysfunction than those with sleep latencies of less than 16 min after adjusting confounders (OR = 0.33, 95% CI 0.23 to 0.47, p &lt; 0.001). Fourth, participants who woke up once (OR = 1.65, 95% CI 1.19 to 2.30, p = 0.003) and three or more times (OR = 2.34, 95% CI 1.25 to 4.36, p = 0.008) after falling asleep had a higher risk than those who did not wake up at night. Last, participants taking sleep medication (OR = 2.97, 95% CI 1.19 to 7.45, p = 0.020) were more vulnerable to cognitive dysfunction, relative to participants without taking any medications.ConclusionOur results suggest that after adjustment for potential confounding variables, poor sleep quality is associated with cognitive dysfunction.
Quantitative reliability assessment of brain MRI volumetric measurements in type II GM1 gangliosidosis patients
Authors: Zoppo Christopher , Kolstad Josephine , Johnston Jean , D'Souza Precilla , Kühn Anna Luisa , Vardar Zeynep , Peker Ahmet , Lindsay Clifford , Rentiya Zubir S. , King Robert , Gray-Edwards Heather , Vachha Behroze , Acosta Maria T. , Tifft Cynthia J. , Shazeeb Mohammed Salman 
Published: September 2024

PurposeGM1-gangliosidosis (GM1) leads to extensive neurodegenerative changes and atrophy that precludes the use of automated MRI segmentation techniques for generating brain volumetrics. We developed a standardized segmentation protocol for brain MRIs of patients with type II GM1 and then assessed the inter- and intra-rater reliability of this methodology. The volumetric data may be used as a biomarker of disease burden and progression, and standardized methodology may support research into the natural history of the disease which is currently lacking in the literature.ApproachTwenty-five brain MRIs were included in this study from 22 type II GM1 patients of which 8 were late-infantile subtype and 14 were juvenile subtype. The following structures were segmented by two rating teams on a slice-by-slice basis: whole brain, ventricles, cerebellum, lentiform nucleus, thalamus, corpus callosum, and caudate nucleus. The inter- and intra-rater reliability of the segmentation method was assessed with an intraclass correlation coefficient as well as Sorensen-Dice and Jaccard coefficients.ResultsBased on the Sorensen-Dice and Jaccard coefficients, the inter- and intra-rater reliability of the segmentation method was significantly better for the juvenile patients compared to late-infantile (p &lt; 0.01). In addition, the agreement between the two rater teams and within themselves can be considered good with all p-values &lt; 0.05.ConclusionsThe standardized segmentation approach described here has good inter- and intra-rater reliability and may provide greater accuracy and reproducibility for neuromorphological studies in this group of patients and help to further expand our understanding of the natural history of this disease.