bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic Profile of Acute Kidney Injury Following the Fontan Procedure: Impact of Renal Perfusion Pressure
Authors: Patterson Taylor , Hehir David A. , Buelow Matthew , Simpson Pippa M. , Mitchell Michael E. , Zhang Liyun , Eslami Mehdi , Murkowski Kathleen , Scott John P. 
Published: May 2017

Background: Acute kidney injury (AKI) is common following cardiopulmonary bypass. Fontan completion may result in systemic venous hypertension and low cardiac output, reducing renal perfusion pressure (RPP) and further increasing the risk of AKI. We investigated the incidence and risk factors for post-Fontan AKI. Methods: Single-center retrospective study of children undergoing Fontan completion from 2005 to 2012. Demographic and hemodynamic variables were assessed for association with AKI. Subgroup analysis was performed on patients with high-grade AKI (creatinine increase of ≥2.0 × baseline). Vital sign data were collected hourly for the first postoperative day. Results: A total of 186 patients underwent Fontan at 3.1 (2.5-3.8) years of age and 13.5 kg (12.2-15.1). Acute kidney injury occurred in 97 (52%) patients, with high-grade AKI in 52 (28%). Univariate analysis identified reduced RPP in patients with AKI compared to those without AKI, 50 (45-56) mm Hg versus 58 (54-61) mm Hg ( P < .0001), due to lower mean arterial blood pressure, 63 (60-69) versus 70 (66-73) mm Hg ( P < .0001), and higher central venous pressure, 14 (12-16) versus 13 (11-14) mm Hg, ( p < .0001). Multivariable logistic regression and classification tree analyses further identified elements of RPP as significant predictors of AKI, especially high-grade AKI. Postoperative intubation was linked to AKI development. Patients with AKI had decreased postoperative urine output with increased colloid requirements, duration of chest tube insertion, and hospital length of stay. Conclusion: Acute kidney injury occurs frequently following the Fontan procedure. Associated factors include reduced RPP, high colloid requirements, and postoperative intubation. Targeted hemodynamic interventions may serve to reduce the incidence of post-Fontan AKI.
Lessons Learned From a Critical Analysis of the Fontan Operation Over Three Decades in a Single Institution
Authors: Caneo Luiz Fernando , Turquetto Aida L. R. , Neirotti Rodolfo A. , Binotto Maria A. , Miana Leonardo A. , Tanamati Carla , Penha Juliano G. , Silveira João B. D. , Alexandre e Silva Thais M. , Jatene Fabio B. , Jatene Marcelo B. 
Published: May 2017

Background: The Fontan operation (FO) has evolved and many centers have demonstrated improved results relative to those from earlier eras. We report a single-institution experience over three decades, describing the outcomes and evaluating risk factors. Methods: Successive patients undergoing primary FO were divided into era I (1984-1994), era II (1995-2004), and era III (2005-2014). Clinical and operative notes were reviewed for demographic, anatomic, and procedure details. End points included early and late mortality and a composite of death, heart transplantation (HTX), or Fontan takedown. Results: A total of 420 patients underwent 18 atriopulmonary connections, 82 lateral tunnels (LT), and 320 extracardiac conduit (EC) Fontan procedures. Forty-six (11%) patients died; early and late mortality were 7.9% and 3.1%, respectively. Eight (1.9%) patients underwent HTX, 11 (2.6%) underwent Fontan conversion to EC, and 1 (0.2%) takedown of EC to bidirectional Glenn shunt. Prevalence of concomitant valve surgery ( P < .001) and pulmonary artery reconstruction ( P < .001) differed over the eras. Preoperative valve regurgitation was associated with likelihood of early mortality (odds ratio [OR] = 3.5, P = .002). Embolic events (OR = 1.9, P = .047), preoperative valve regurgitation (OR = 2.3, P = .029), diagnosis of unbalanced atrioventricular canal defect (OR = 1.14, P = .03), and concomitant valve replacement (OR = 6.9, P = .001) during the FO were associated with increased risk of the composite end point (death, HTX, or takedown). Conclusion: Technical modifications did not result in improved results across eras, due in part to more liberal indications for surgery in the recent years. Valve regurgitation, unbalanced atrioventricular canal, embolic events, or concomitant valve replacement were associated with FO failure.
BCL2 expression in DLBCL: reappraisal of immunohistochemistry with new criteria for therapeutic biomarker evaluation
Authors: Tsuyama Naoko , Sakata Seiji , Baba Satoko , Mishima Yuko , Nishimura Noriko , Ueda Kyoko , Yokoyama Masahiro , Terui Yasuhito , Hatake Kiyohiko , Kitagawa Masanobu , Ishizuka Naoki , Tomita Naoto , Takeuchi Kengo 
Published: May 2017

Key Points
A BCL2 IHC score is a strong prognostic factor independent of the IPI and MYC protein/rearrangement status in DLBCL treated with R-CHOP. The BCL2 scoring system we propose is a simple, at-a-glance, and highly reliable system, which was confirmed by an image analysis.
NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock
Authors: Chen Shuhua , Hoffman Rosemary A , Scott Melanie , Manson Joanna , Loughran Patricia , Ramadan Mostafa , Demetris Anthony J , Billiar Timothy R 
Published: May 2017

Abstract
Various cell populations expressing NK1.1 contribute to innate host defense and systemic inflammatory responses, but their role in hemorrhagic shock and trauma remains uncertain. NK1.1+ cells were depleted by i.p. administration of anti-NK1.1 (or isotype control) on two consecutive days, followed by hemorrhagic shock with resuscitation and peripheral tissue trauma (HS/T). The plasma levels of IL-6, MCP-1, alanine transaminase (ALT), and aspartate aminotransferase (AST) were measured at 6 and 24 h. Histology in liver and gut were examined at 6 and 24 h. The number of NK cells, NKT cells, neutrophils, and macrophages in liver, as well as intracellular staining for TNF-α, IFN-γ, and MCP-1 in liver cell populations were determined by flow cytometry. Control mice subjected to HS/T exhibited end organ damage manifested by marked increases in circulating ALT, AST, and MCP-1 levels, as well as histologic evidence of hepatic necrosis and gut injury. Although NK1.1+ cell–depleted mice exhibited a similar degree of organ damage as nondepleted animals at 6 h, NK1.1+ cell depletion resulted in marked suppression of both liver and gut injury by 24 h after HS/T. These findings indicate that NK1.1+ cells contribute to the persistence of inflammation leading to end organ damage in the liver and gut.
Impacts of Reducing the Shelf Life of Red Blood Cells: A View from Down Under
Authors: Abbasi Babak , Vakili Golnaz , Chesneau Stuart 
Published: May 2017

Red blood cells (RBCs) are the most commonly used blood product. A body of literature is available to both support and oppose the concept that patient outcomes are negatively impacted when older blood is transfused. This has led to further research to analyze the impacts of reducing the shelf life of RBCs through the lenses of wastage and cost, and most importantly, sufficiency of supply. In this study, we look at the implications of decreasing the shelf life of RBCs in the state of New South Wales (NSW). We develop a discrete-event simulation model that considers the complexities of a two-echelon inventory system, as characterized by the blood product supply chain in Australia. The results show that reducing the shelf life of RBCs would, as we expect, result in fresher blood being transfused to patients. However, a reduction of 21 days would not be tolerated by that system based on current policy and practices; would result in a loss of control, vastly increased shortages, and (or) outdated RBCs; and would result in greater risk to patient care. Our model also evaluates the impact of operational policies on the NSW blood supply chain. The electronic companion is available at https://doi.org/10.1287/inte.2017.0899 .
Distance of translation as a predictor of failure of fixation in paediatric supracondylar fractures
Authors: Holland P , Highcock A , Bruce C 
Published: May 2017

Introduction This study investigates the influence of incomplete reduction of supracondylar fractures on the incidence of loss of reduction requiring reoperation Materials and methods A review of 107 consecutive patients presenting with supracondylar fractures treated with closed reduction and Kirschner wire stabilisation, between January 2011 and March 2013, was conducted. The mean age was 5 years (range 10 months to 12 years). Pre-, intra- and postoperative radiographs were reviewed. All patients who had failure of fixation requiring revision surgery were identified. Results Ninety-nine patients had an initial adequate radiographic reduction. Of these, one (1%) required revision surgery. Eight patients had an initial incomplete radiographic reduction and, of these, six (75%) required revision surgery (P < 0.0001). Discussion Supracondylar fractures treated with closed reduction and K wire stabilisation require adequate intraoperative reduction. Incomplete reduction should not be accepted, as despite the bones potential to remodel, the risk of further loss of reduction is high, requiring reoperation.
Österreichs Sozialstaat im Vergleich internationaler Makrodaten
Authors: Obinger Herbert 
Published: May 2017

Dieser Beitrag vermisst anhand von über 30 Makroindikatoren das Profil und die Performanz des österreichischen Sozialstaates im internationalen Vergleich. Neben Ausgabenniveaus und Finanzierungsstruktur werden die Generosität und der Inklusionsgrad ausgewählter Sicherungssysteme sowie die Performanz in den Bereichen Einkommensverteilung und Beschäftigung in den Blick genommen. Der Vergleich zeigt, dass Österreichs Sozialstaat trotz ausgeprägter Bismarckscher Strukturmerkmale eine deutlich überdurchschnittliche Leistungsfähigkeit aufweist.
Die deutsch-tschechischen Beziehungen und die Präsidentschaftswahl 2013
Authors: Novotný Lukáš 
Published: May 2017

Ziel dieser Studie ist es, die Rolle der deutsch-tschechischen Beziehungen bei der Präsidentschaftswahl 2013 in Tschechien zu analysieren. Insbesondere geht es um die Frage, inwieweit Geschichtsthemen wie die Vertreibung der deutschen Bevölkerung sowie die Benes-Dekrete eine Rolle im Wahlkampf spielten. Es zeigt sich, dass sie das Ergebnis der Wahl nicht in entscheidendem Ausmaß beeinflusst haben, was nicht zuletzt an dem geringen Abstand zwischen den beiden verbleibenden Kandidaten in der zweiten Runde ersichtlich wurde. Dies ist bemerkenswert auch deshalb, wenn man sich vor Augen hält, welch explosive Rolle Vertreibung und Dekrete vor einigen Jahren in Tschechien noch hatten.
Politikverdrossenheit oder kritische Demokraten? Eine Analyse der Einstellungen zur direkten Demokratie in Österreich im Lichte von drei theoretischen Ansätzen
Authors: Wirnsberger Sarah , Haller Max 
Published: May 2017

Wird die direkte Demokratie in Österreich diskutiert, geschieht dies zumeist ohne Einbezug der BürgerInnen als politische AkteurInnen. Auf Basis einer repräsentativen Umfrage aus dem Jahr 2012 (n=2000) wird der Frage nachgegangen, wie sich die öffentliche Meinung in diesem Kontext gestaltet und welche soziodemographischen und politischen Faktoren diese Haltungen begründen. Theoretisch werden drei Ansätze verglichen, die hinsichtlich ihrer Erklärungsleistungen in Konkurrenz zueinander stehen und jeweils andere normative Schlussfolgerungen für sich beanspruchen: new politics, political disaffection und die partizipatorische Demokratietheorie. Dabei zeigt sich, dass keine Theorie für sich einen hohen empirischen Gehalt aufweist, aber jede bestimmte Aspekte erklären kann. Aufgrund der hohen Zustimmung zum Ausbau der direkten Demokratie über alle Bevölkerungsschichten hinweg lassen sich insgesamt nur geringe Erklärungsleistungen auf Basis dieser Modelle erreichen.
Stubborn hiccups as a sign of massive apoplexy in a naive acromegaly patient with pituitary macroadenoma
Authors: Simsek Bagir Gulay , Civi Soner , Kardes Ozgur , Kayaselcuk Fazilet , Ertorer Melek Eda 
Published: May 2017

Summary
Pituitary apoplexy (PA) may very rarely present with hiccups. A 32-year-old man with classical acromegaloid features was admitted with headache, nausea, vomiting and stubborn hiccups. Pituitary magnetic resonance imaging (MRI) demonstrated apoplexy of a macroadenoma with suprasellar extension abutting the optic chiasm. Plasma growth hormone (GH) levels exhibited suppression (below <1 ng/mL) at all time points during GH suppression test with 75 g oral glucose. After treatment with corticosteroid agents, he underwent transsphenoidal pituitary surgery and hiccups disappeared postoperatively. The GH secretion potential of the tumor was clearly demonstrated immunohistochemically. We conclude that stubborn hiccups in a patient with a pituitary macroadenoma may be a sign of massive apoplexy that may result in hormonal remission.

Learning points:

Patients with pituitary apoplexy may rarely present with hiccups.

Stubborn hiccupping may be a sign of generalized infarction of a large tumor irritating the midbrain.

Infarction can be so massive that it may cause cessation of hormonal overproduction and result in remission.
Glucocorticoid-responsive lymphocytic parathyroiditis and hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor: a case report and literature review
Authors: Song Li , Liu Liping , Miller R Tyler , Yan Shirley X , Jackson Nancy , Holt Shelby A , Maalouf Naim M 
Published: May 2017

Objective
Autoimmune lymphocytic parathyroiditis and acquired hypocalciuric hypercalcemia associated with autoantibodies against the calcium-sensing receptor (anti-CaSR) are rare and poorly understood conditions. Here, we describe a patient with acquired parathyroid hormone (PTH)-dependent hypercalcemia with associated hypocalciuria, found to have true lymphocytic parathyroiditis on histopathology, and circulating anti-CaSR antibodies in serum.

Design and methods
A 64-year-old woman was referred to our clinic for persistent hypercalcemia after a subtotal parathyroidectomy. She was normocalcemic until the age of 63 years when she was diagnosed with primary hyperparathyroidism. She underwent subtotal parathyroidectomy with appropriate intraoperative PTH decline. Two weeks post-parathyroidectomy, she presented with persistent hypercalcemia and hyperparathyroidism. Urine studies revealed an inappropriately low 24-h urine calcium (Ca)/creatinine clearance ratio. Surgical pathology was consistent with true lymphocytic parathyroiditis with lymphoid follicles. The presence of circulating anti-CaSR antibodies was detected by immunoprecipitation of CaSR by the patient’s serum. After a 4-week course of prednisone, serum Ca and PTH normalized, and her anti-CaSR titers declined. She remains normocalcemic 10 months after the discontinuation of glucocorticoid therapy. We present this patient in the context of the relevant published literature on lymphocytic parathyroiditis and acquired hypocalciuric hypercalcemia related to anti-CaSR antibodies.

Conclusions
Autoimmune lymphocytic parathyroiditis and acquired hypocalciuric hypercalcemia associated with anti-CaSR antibodies is a very rare yet important condition to be considered in a patient with acquired PTH-dependent hypercalcemia with inappropriate hypocalciuria. Although subtotal parathyroidectomy is unlikely to correct the hypercalcemia, this entity may respond to a short course of prednisone therapy.
The longitudinal association between anxiety and Internet addiction in adolescence: The moderating effect of classroom extraversion
Authors: Stavropoulos Vasileios , Gomez Rapson , Steen Eloisa , Beard Charlotte , Liew Lucas , Griffiths Mark D. 
Published: May 2017

Background and aimsThe risk effect of anxiety on addictive behaviors, including Internet addiction (IA), has repeatedly been highlighted in the international literature. However, there is a lack of longitudinal studies examining this association in relation to proximal context effects, particularly in adolescence. Such findings would shed light on potential age- and proximal context-related variations in the anxiety–IA association that could better inform IA prevention and intervention initiatives.MethodsIn this study, 648 adolescents, embedded in 34 classrooms, were assessed at the age of 16 and again at the age of 18 to examine the effect of anxiety on IA behaviors in relation to the average level of classroom extraversion. IA was assessed with the Internet Addiction Test (Young, 1998), anxiety with the relevant subscale of the Symptom Checklist 90 – Revised (Derogatis & Savitz, 1999) and classroom extraversion with the synonymous subscale of the Five Factor Questionnaire (Asendorpf & van Aken, 2003). A three-level hierarchical linear model was calculated.ResultsThe present findings demonstrated that: (a) higher levels of anxiety were significantly associated with higher IA behaviors, (b) the strength of this association did not vary over time (between 16 and 18 years old), and (c) however, it tended to weaken within classrooms higher in extraversion.DiscussionThis study indicated that the contribution of individual IA risk factors might differently unfold within different contexts.
Phylogenetic diversity of microorganisms associated with three marine sponges from Mien Trung sea of Vietnam
Authors: Cuc Nguyen Thi Kim , Dat Ton That Huu , Hong Tran Thi , Cuong Pham Viet 
Published: May 2017

Using culture - independent technique, hypervariable V4 region of 16S rDNA library sequencing by MiSEq, the baterial communities of three host sponges Rhabdastrella sp. DN, Spheciospongia sp. QT and Clathria sp. NT from Mien Trung sea were characterized. The phylogenetic analysis showed that bacterial community structures of the three investigated sponges similar to each other regarding 10 common phyla, although abundance of these phyla was different for each sponge. Phylum Thaumarchaeota was rich component for three sponges, especially in NT sponge (31.89%). In this sponge, 3 phyla Planctomycetes, Verrucomicrobia and Firmicutes were undetected in other 2 sponge samples. Phyla Cyanobacteria was observed only in DN sponge. The obtained amplicons were assigned in different taxonomic levels (class, order, family and genus) based on Silva database. At class level, Gammaproteobacteria was abundant in three sponges; and Caldilineae, Marine-group I were dominant in DN; mealwile, in QT other dominant classes were Marine-group I and Betaproteobacteria. For NT, they were Cytophaga and Deferribacteres. In general, all three sponges harbored abundant and genetically diverse microbial associated consortia and they shared several common bacterial operational taxonomic units, although with different abundance.
DE LA FILOSOFIA A LA COMUNICACIÓN POR EL CAMINO DE LA CULTURA. Desafíos de las dinámicas de la comunicación a la formación docente
Authors: Vásquez Arrieta Tomás 
Published: May 2017

Entrevista a Jesús Martín-Barbero De formación filosófica, Jesús MartínBarbero incursionó en el campo de la comunicación desde mediados de la década de los setenta y, desde entonces, sin duda alguna es uno de los máximos dinamizadores del debate, la reflexión y la investigación en este terreno en el ámbito latinoamericano. Entre sus múltiples actividades académicas podemos destacar que ha sido investigador asociado en la Facultad de Ciencias de la Información en la Universidad Complutense de Madrid, profesor visitante en la Cátedra Unesco de Comunicación en la Universidad Autónoma de Barcelona, en la División de Literaturas, Culturas y lenguajes de la Universidad de Stanford, en Escuelas de Antropología e Historia de México y profesor investigador de Iteso en la Universidad de Guadalajara.
Comprensión de los procesos de inclusión educativa de estudiantes sordos desde una perspectiva organizacional
Authors: Salazar Restrepo Pablo Alejandro 
Published: May 2017

Este artículo parte de la investigación señalada con el mismo nombre en donde se analizan procesos de inclusión de estudiantes sordos del colegio Federico García Lorca desde una perspectiva organizacional. El estudio recurrió a una encuesta que analizó dos variables: estructuras y prácticas organizacionales. Los análisis se contrastaron en grupos focales con la percepción de directivos, docentes, estudiantes, padres de familia y personal administrativo. La inclusión cuenta con un compromiso importante entre miembros de la comunidad educativa, aunque se hace necesario fortalecer el trabajo cooperativo entre los docentes.
La constitución de las Culturas Pedagógicas Modernas: Una aproximación conceptual
Authors: Noguera Ramírez Carlos Ernesto 
Published: May 2017

El artículo parte de la tesis según la cual la constitución de la llamada ";Pedagogía Moderna"; corresponde en realidad a la instauración, durante el siglo XIX, de tres tradiciones intelectuales en cuyo centro es posible identificar problemáticas o conceptos particulares propios de sus ambientes culturales: el francófono, el germánico y el anglosajón. Así, las aproximaciones a la educación para la tradición francófona, a la Building o formación para la tradición germánica y al currículo para la tradición anglosajona, quedan esbozadas aquí a manera de una ‘cartografía conceptual’ de lo que podría llamarse las Culturas Pedagógicas Modernas.
ESTUDIO DE LA IMAGEN DE CIENCIA EN ESTUDIANTES DE SECUNDARIA A TRAVÉS DE SU INTERACCIÓN CON UNA ESTRATEGIA DIDÁCTICA MEDIADA POR UN VIDEOJUEGO, EN TORNO AL CONCEPTO DE HUMEDAL
Authors: Abella Susana 
Published: May 2017

La naturaleza de las ciencias (NOS) es una metaciencia que articula la epistemología, la historia y la sociología de las ciencias con el fin de contribuir a la reflexión sobre la imagen de ciencia desde cuestiones sociales que se genera en la educación, se retroalimenta con la didáctica de las ciencias para transformar la forma de enseñarla (Aduriz, 2005a). De allí surge un interés por averiguar los conceptos epistémicos respecto a la imagen de ciencias que manejan los estudiantes de grado noveno y ampliarlos desde la representación de algunas situaciones sociales e históricas que marcan la transformación de los humedales de Bogotá, mediante el diseño y aplicación de una unidad didáctica que incluye como actividad central un videojuego, para analizar a partir de las habilidades cognitivolingüísticas planteadas por Jorba (2000), si se da una aproximación a una visión más socio científica. Por lo anterior, que los resultados pretendan llegar a reconocer en el lenguaje escrito y sustentado por el lenguaje oral de los educandos, nuevos valores epistémicos de la concepción humedal y allí se identifican razones significativas al hacerles ver que las nuevas ideas están ‘justificadas’ por la realidad tomada desde diversas percepciones, idea apoyada por De Longhi (2007).