bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empresa de fruticultura irrigada do Vale do São Francisco: uma análise sob as metáforas de Morgan
Authors: Azevêdo Arlete Colaço de , Tabosa Jackeline Alves de Lucena , Oliveira Deranor Gomes de 
Published: September 2024

Este estudo analisou a empresa Sweet Fruits, uma empresa de fruticultura irrigada localizada no Vale do São Francisco, na cidade de Petrolina-PE, que se encontra em processo de recuperação judicial. A análise utilizou as metáforas propostas por Gareth Morgan para identificar os fatores que contribuíram para a crise. Os resultados mostraram que a empresa enfrentou uma série de problemas, que podem ser agrupados em torno das cinco metáforas utilizadas: máquina (estrutura organizacional rígida e modelo de produção tradicional); organismo (não adaptação às mudanças ambientais e dificuldade de inovação e crescimento); fluxo e transformação (interrupção no fluxo de crescimento, perda de competitividade e rentabilidade); sistema político (gestão ineficiente e problemas de comercialização); cérebro (tomada de decisões equivocadas implementação ineficaz das estratégias direcionadas aos grupos de interesse). Cada metáfora fornece uma perspectiva diferente, e com base na análise, foram propostas as seguintes soluções para a recuperação da empresa: adoção de uma estrutura organizacional mais flexível e um modelo de produção inovador; investimento em pesquisa e desenvolvimento; melhoria do processo de tomada de decisão; investimento em um programa de motivação e valorização dos funcionários; adoção de um sistema de gestão mais participativo. As metáforas propostas por Morgan fornecem uma visão holística da organização, que pode ser útil para identificar os fatores que contribuem para a crise. O estudo foi baseado em uma análise de dados secundários, o que limita a sua validade. Contudo, contribui para a compreensão dos problemas enfrentados por organizações que passam por recuperação judicial.
Outcome of neoadjuvant therapies for cancer of the oesophagus or gastro-oesophageal junction based on a national data registry
Authors: Klevebro F , Lindblad M , Johansson J , Lundell L , Nilsson M 
Published: October 2016

Abstract

Background
Randomized trials have shown that neoadjuvant treatment improves survival in the curative treatment of oesophageal and gastro-oesophageal junction cancer. Results from population-based observational studies are, however, sparse and ambiguous.

Methods
This prospective population-based cohort study included all patients who had oesophagectomy for cancer in Sweden, excluding clinical T1 N0, recorded in the National Register for Oesophageal and Gastric Cancer, 2006–2014. Patients were stratified into three groups: surgery alone, neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy.

Results
Neoadjuvant treatment was given to 521 patients (51·1 per cent) and 499 (48·9 per cent) received surgery alone. Neoadjuvant chemotherapy increased the risk of postoperative surgical complications compared with surgery alone (adjusted odds ratio 2·01, 95 per cent c.i. 1·24 to 3·25; P = 0·005). Postoperative mortality was significantly increased after neoadjuvant chemoradiotherapy compared with surgery alone (odds ratio 2·37, 1·06 to 5·29; P = 0·035). Survival improved in patients with squamous cell carcinoma after neoadjuvant chemotherapy, whereas after neoadjuvant chemoradiotherapy survival was significantly improved only in the subgroup with the highest performance status and without known co-morbidity. In adenocarcinoma there was a trend towards improved overall survival after neoadjuvant chemotherapy, but neoadjuvant chemoradiotherapy did not offer a survival benefit. Stratified analysis including only patients with adenocarcinoma in the highest performance category without known co-morbidity showed a strong trend towards improved survival after neoadjuvant chemotherapy compared with surgery alone (adjusted hazard ratio 0·47, 0·21 to 1·04; P = 0·061).

Conclusion
For patients with squamous cell carcinoma of the oesophagus or gastro-oesophageal junction, neoadjuvant treatments seemed to increase long-term survival, but also the risk of postoperative morbidity and mortality, compared with surgery alone. Neither neoadjuvant treatment option seemed to improve survival significantly among patients with adenocarcinoma, compared with surgery alone.
Human Rights Impact Assessment of Business Activities: Key Criteria for Establishing a Meaningful Practice
Authors: GÖTZMANN Nora 
Published: October 2016

AbstractThis article considers the emerging practice of human rights impact assessment (HRIA) in the field of business and human rights. As HRIA is relatively new, current approaches vary considerably, indicating that there is a need for the business and human rights community to engage in further dialogue and debate about what good practice HRIA can and should entail. I propose five key criteria for HRIA of business activities: (1) applying international human rights standards; (2) considering the full scope of impacts; (3) adopting a human rights-based process; (4) ensuring accountability; and (5) addressing impacts according to severity. It is suggested that these criteria should form the basis of methodologies used to assess human rights impacts of business activities, with the view to developing HRIA practice that meaningfully contributes to preventing and addressing adverse impacts of business activities on the human rights enjoyment of workers and communities.
Lipids and polyunsaturated fatty acid levels in deliberate self-harm: a 10-year follow-up study
Authors: Gallagher A. T. , Byrne F. , Murray I. T. , Lally J. , Davis J. M. , Garland M. , Hibbeln J. R. , Hallahan B. 
Published: October 2016

ObjectivesTo evaluate if n-3 polyunsaturated fatty acids (PUFAs) and lipid levels are associated with episodes of self-harm or depression over a 10-year period.MethodsWe included 40 individuals who self-harmed and 40 controls. Episodes of self-harm and depression were ascertained and levels of depression, impulsivity, suicidal ideation and plasma lipid levels measured at baseline and at 10-year follow-up.ResultsFurther episode(s) of self-harm occurred in 26% of cases. Omega-3 PUFAs or lipids were not predictive of depressive or self-harm episodes. Baseline eicosapentaenoic acid levels were modestly correlated with suicidal ideation at follow-up and dihomo-γ-linolenic acid and arachidonic acid were modestly correlated with motor impulsivity at follow-up in cases.ConclusionsDespite significant negative correlations at baseline between plasma lipids, n-3 PUFAs and psychopathology, these levels were not predictive of clinical outcome over a 10-year period. Further research however is required due to the relatively low sample size and the risk of selection bias due to loss to follow-up in this study.
Diversity and composition of plants, butterflies and odonates in an Imperata cylindrica grassland landscape in East Kalimantan, Indonesia
Authors: Cleary D.F.R. 
Published: October 2016

Abstract:In Indonesia and elsewhere, Imperata cylindrica grassland now covers millions of hectares of land previously covered by rain forest. In the present study, shrubs, trees and climbers were recorded in sixteen 10 × 20-m plots and herb cover (ferns, grasses and herbaceous dicots) estimated in nested 2 × 2-m subplots. Butterflies and odonates were netted along 300-m transects. All plots and transects were randomly allocated to a 450 ha, I. cylindrica-dominated landscape. A total of 43 shrub, tree and climber, 16 herb, 67 butterfly and 30 odonate species were recorded. Shrubs, trees and climbers were present throughout the study area, but basal area was very low and mainly consisted of invasive species. Imperata cylindrica covered an estimated 65% of the area with other plant species or bare soil covering the remainder. Butterfly and odonate communities mainly consisted of species with large geographic distributions, but some recorded species had more limited distributions. The latter were, however, species known to associate with perturbed forest environments. Variation in the composition of butterflies and odonates was also related to variation in habitat structure (e.g. altitude and slope) and plant composition. Plant composition in particular appeared to structure both butterfly and odonate communities.
Automatic derivation of design schemata and subsequent generation of designs
Authors: Reed Kate , Gillies Duncan 
Published: October 2016

AbstractThis paper presents a method for automatically generating new designs from a set of existing objects of the same class using machine learning. In this particular work, we use a custom parametric chair design program to produce a large set of chairs that are tested for their physical properties using ergonomic simulations. Design schemata are found from this set of chairs and used to generate new designs by placing constraints on the generating parameters used in the program. The schemata are found by training decision trees on the chair data sets. These are automatically reverse engineered by examining the structure of the trees and creating a schema for each positive leaf. By finding a range of schemata, rather than a single solution, we maintain a diverse design space. This paper also describes how schemata for different properties can be combined to generate new designs that possess all properties required in a design brief. The method is shown to consistently produce viable designs, covering a large range of our design space, and demonstrates a significant time saving over generate and test using the same program and simulations.
The effectiveness of a visual image analysis (VIA) system for monitoring the performance of growing/finishing pigs
Authors: White R. P. , Schofield C. P. , Green D. M. , Parsons D. J. , Whittemore C. T. 
Published: October 2016

AbstractA visual image analysis (VIA) system provided continuous, automatic collection of size and shape data for a total of 116 pigs slaughtered serially from 25 to 115 kg live weight. Males and females of three types of pigs (‘Meishan’ type, ‘Pietrain’ type, and ‘Landrace’ type) were selected to provide variation in both composition and conformation (the three types being, respectively, ‘fat’, ‘blocky’, and ‘lean’). Results below are presented in this order. Regression analysis was used to relate VIA size to platform weigher (FIRE) measurements of live weight. Residual maximum likelihood (REML) analysis showed that at the observed growth rate, a change in pig state could be detected by VIA after 8, 9, and 10 days respectively for the three types, and by the platform weigher system after 12, 4, and 13 days (in both cases with a confidence of 95%). Artificial neural network and canonical variates analysis were used to test the ability of VIA to distinguish between pig types and sexes. With cross validation, the canonical variates analysis correctly classified the three types in 72, 83, and 64% of observations, and the neural network in 81, 81, and 64% of observations. The VIA system is considered to be a valuable monitoring system which may play a rôle in the construction of integrated management systems (IMS).
Wavelength-scale light concentrator made by direct 3D laser writing of polymer metamaterials
Authors: Moughames J. , Jradi S. , Chan T. M. , Akil S. , Battie Y. , Naciri A. En , Herro Z. , Guenneau S. , Enoch S. , Joly L. , Cousin J. , Bruyant A. 
Published: October 2016

AbstractWe report on the realization of functional infrared light concentrators based on a thick layer of air-polymer metamaterial with controlled pore size gradients. The design features an optimum gradient index profile leading to light focusing in the Fresnel zone of the structures for two selected operating wavelength domains near 5.6 and 10.4 μm. The metamaterial which consists in a thick polymer containing air holes with diameters ranging from λ/20 to λ/8 is made using a 3D lithography technique based on the two-photon polymerization of a homemade photopolymer. Infrared imaging of the structures reveals a tight focusing for both structures with a maximum local intensity increase by a factor of 2.5 for a concentrator volume of 1.5 λ3, slightly limited by the residual absorption of the selected polymer. Such porous and flat metamaterial structures offer interesting perspectives to increase infrared detector performance at the pixel level for imaging or sensing applications.
What determines the interfacial configuration of Nb/Al2O3 and Nb/MgO interface
Authors: Du J. L. , Fang Y. , Fu E. G. , Ding X. , Yu K. Y. , Wang Y. G. , Wang Y. Q. , Baldwin J. K. , Wang P. P. , Bai Q. 
Published: October 2016

AbstractNb films are deposited on single crystal Al2O3 (11"Equation missing"0) and MgO(111) substrates by e-beam evaporation technique. Structure of Nb films and orientation relationships (ORs) of Nb/Al2O3 and Nb/MgO interface are studied and compared by the combination of experiments and simulations. The experiments show that the Nb films obtain strong (110) texture, and the Nb film on Al2O3(11"Equation missing"0) substrate shows a higher crystalline quality than that on MgO(111) substrate. First principle calculations show that both the lattice mismatch and the strength of interface bonding play major roles in determining the crystalline perfection of Nb films and ORs between Nb films and single crystal ceramic substrates. The fundamental mechanisms for forming the interfacial configuration in terms of the lattice mismatch and the strength of interface bonding are discussed.
Tunable Surface Plasmon and Phonon Polariton Interactions for Moderately Doped Semiconductor Surfaces
Authors: Janipour Mohsen , Misirlioglu Ibrahim Burc , Sendur Kursat 
Published: October 2016

AbstractSpatial charge distribution for biased semiconductors fundamentally differs from metals since they can allow inhomogeneous charge distributions due to penetration of the electric field, as observed in the classical Schottky junctions. Similarly, the electrostatics of the dielectric/semiconductor interface can lead to a carrier depletion or accumulation in the semiconductor side when under applied bias. In this study, we demonstrate that the inhomogeneous carrier accumulation in a moderately p-doped GaAs–dielectric interface can be tailored for tunable plasmonics by an external voltage. Solving Maxwell’s equations in the doped GaAs-dielectric stack, we investigate the tunability of the surface plasmon and phonon polaritons’ interaction via an external bias. The plasmonic mode analysis of such an interface reveals interesting dispersion curves for surface plasmon and phonon polariton interactions that are not possible in metals. We show that the plasmon dispersion curve can be engineered through an external bias using the inherent properties of the p-doped GaAs– dielectric interface.
Three representations of the Ising model
Authors: Kruis Joost , Maris Gunter 
Published: October 2016

AbstractStatistical models that analyse (pairwise) relations between variables encompass assumptions about the underlying mechanism that generated the associations in the observed data. In the present paper we demonstrate that three Ising model representations exist that, although each proposes a distinct theoretical explanation for the observed associations, are mathematically equivalent. This equivalence allows the researcher to interpret the results of one model in three different ways. We illustrate the ramifications of this by discussing concepts that are conceived as problematic in their traditional explanation, yet when interpreted in the context of another explanation make immediate sense.
Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies
Authors: Grandjean Capucine L. , Montalvao Fabricio , Celli Susanna , Michonneau David , Breart Beatrice , Garcia Zacarias , Perro Mario , Freytag Olivier , Gerdes Christian A. , Bousso Philippe 
Published: October 2016

AbstractAnti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADP) as reported by in vitro studies. However, where and how glycoengineered Ab may potentiate therapeutic responses in vivo is yet to be elucidated. Here, we have performed mouse liver transplants to demonstrate that the liver is sufficient to mediate systemic B cells depletion after anti-CD20 treatment. Relying on intravital two-photon imaging of human CD20-expressing mice, we provide evidence that ADP by Kupffer cells (KC) is a major mechanism for rituximab-mediated B cell depletion. Notably, a glycoengineered anti-mouse CD20 Ab but not its wild-type counterpart triggered potent KC-mediated B cell depletion at low doses. Finally, distinct thresholds for KC phagocytosis were also observed for GA101 (obinutuzumab), a humanized glycoengineered type II anti-CD20 Ab and rituximab. Thus, we propose that enhanced phagocytosis of circulating B cells by KC represents an important in vivo mechanism underlying the improved activity of glycoengineered anti-CD20 mAbs.
Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells
Authors: Moosavi Mohammad Amin , Sharifi Maryam , Ghafary Soroush Moasses , Mohammadalipour Zahra , Khataee Alireza , Rahmati Marveh , Hajjaran Sadaf , Łos Marek J. , Klonisch Thomas , Ghavami Saeid 
Published: October 2016

AbstractIn this study, we used nitrogen-doped titanium dioxide (N-TiO2) NPs in conjugation with visible light, and show that both reactive oxygen species (ROS) and autophagy are induced by this novel NP-based photodynamic therapy (PDT) system. While well-dispersed N-TiO2 NPs (≤100 μg/ml) were inert, their photo-activation with visible light led to ROS-mediated autophagy in leukemia K562 cells and normal peripheral lymphocytes, and this increased in parallel with increasing NP concentrations and light doses. At a constant light energy (12 J/cm2), increasing N-TiO2 NP concentrations increased ROS levels to trigger autophagy-dependent megakaryocytic terminal differentiation in K562 cells. By contrast, an ROS challenge induced by high N-TiO2 NP concentrations led to autophagy-associated apoptotic cell death. Using chemical autophagy inhibitors (3-methyladenine and Bafilomycin A1), we confirmed that autophagy is required for both terminal differentiation and apoptosis induced by photo-activated N-TiO2. Pre-incubation of leukemic cells with ROS scavengers muted the effect of N-TiO2 NP-based PDT on cell fate, highlighting the upstream role of ROS in our system. In summary, PDT using N-TiO2 NPs provides an effective method of priming autophagy by ROS induction. The capability of photo-activated N-TiO2 NPs in obtaining desirable cellular outcomes represents a novel therapeutic strategy of cancer cells.
Histone acetylation dependent energy landscapes in tri-nucleosome revealed by residue-resolved molecular simulations
Authors: Chang Le , Takada Shoji 
Published: October 2016

AbstractHistone tail acetylation is a key epigenetic marker that tends to open chromatin folding and activate transcription. Despite intensive studies, precise roles of individual lysine acetylation in chromatin folding have only been poorly understood. Here, we revealed structural dynamics of tri-nucleosomes with several histone tail acetylation states and analyzed histone tail interactions with DNA by performing molecular simulations at an unprecedentedly high resolution. We found versatile acetylation-dependent landscapes of tri-nucleosome. The H4 and H2A tail acetylation reduced the contact between the first and third nucleosomes mediated by the histone tails. The H3 tail acetylation reduced its interaction with neighboring linker DNAs resulting in increase of the distance between consecutive nucleosomes. Notably, two copies of the same histone in a single nucleosome have markedly asymmetric interactions with DNAs, suggesting specific pattern of nucleosome docking albeit high inherent flexibility. Estimated transcription factor accessibility was significantly high for the H4 tail acetylated structures.
Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites
Authors: Prinz Boris , Harvey Katherine L. , Wilcke Louisa , Ruch Ulrike , Engelberg Klemens , Biller Laura , Lucet Isabelle , Erkelenz Steffen , Heincke Dorothee , Spielmann Tobias , Doerig Christian , Kunick Conrad , Crabb Brendan S. , Gilson Paul R. , Gilberger Tim W. 
Published: October 2016

AbstractCentral to the pathogenesis of malaria is the proliferation of Plasmodium falciparum parasites within human erythrocytes. Parasites invade erythrocytes via a coordinated sequence of receptor-ligand interactions between the parasite and host cell. One key ligand, Apical Membrane Antigen 1 (AMA1), is a leading blood-stage vaccine and previous work indicates that phosphorylation of its cytoplasmic domain (CPD) is important to its function during invasion. Here we investigate the significance of each of the six available phospho-sites in the CPD. We confirm that the cyclic AMP/protein kinase A (PKA) signalling pathway elicits a phospho-priming step upon serine 610 (S610), which enables subsequent phosphorylation in vitro of a conserved, downstream threonine residue (T613) by glycogen synthase kinase 3 (GSK3). Both phosphorylation steps are required for AMA1 to function efficiently during invasion. This provides the first evidence that the functions of key invasion ligands of the malaria parasite are regulated by sequential phosphorylation steps.
TM4 of the glutamate transporter GLT-1 experiences substrate-induced motion during the transport cycle
Authors: Rong Xiuliang , Tan Feng , Wu Xiaojuan , Zhang Xiuping , Lu Lingli , Zou Xiaoming , Qu Shaogang 
Published: October 2016

AbstractExcitatory amino acid transporter 2 (EAAT2), also known as glial glutamate transporter type 1 (GLT-1), plays an important role in maintaining the extracellular glutamate concentrations below neurotoxic levels. The highly conserved TM2 transmembrane domain of GLT-1 maintains a stable position during the transport cycle; however, the effect of the transport cycle on the topology of TM4 in not well established. To further reveal the function of TM4, two cysteine pairs between TM2 and TM4 were introduced using site-directed mutagenesis. A significant decrease of transport activity was observed in the I93C/V241C and I97C/V241C mutants upon application of the oxidative cross-linking reagent, copper (II) (1,10-phenanthroline)3 (CuPh), which suggests that a conformational shift is essential for transporter activity. Furthermore, the decrease in activity by CuPh crosslinking was enhanced in external media with glutamate or potassium, which suggests that TM2 and TM4 assume closer proximity in the inward-facing conformation of the transporter. Our results suggest that the TM4 domain of GLT-1 and potentially other glutamate transporters, undergoes a complex conformational shift during substrate translocation, which involves an increase in the proximity of the TM2 and TM4 domains in the inward-facing conformation.