bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wholesale Funding Dry‐Ups
Authors: PÉRIGNON CHRISTOPHE , THESMAR DAVID , VUILLEMEY GUILLAUME 
Published: October 2017

ABSTRACTWe empirically explore the fragility of wholesale funding of banks, using transaction‐level data on short‐term, unsecured certificates of deposit in the European market. We do not observe a market‐wide freeze during the 2008 to 2014 period. Yet, many banks suddenly experience funding dry‐ups. Dry‐ups predict, but do not cause, future deterioration in bank performance. Furthermore, during periods of market stress, banks with high future performance tend to increase reliance on wholesale funding. We therefore fail to find evidence consistent with adverse selection models of funding market freezes. Our evidence is in line with theories highlighting heterogeneity between informed and uninformed lenders.
A Demonstrative Tactile Method to Guide Mandibular Movements
Authors: Massad Joseph J. , Ahuja Swati A. , Wicks Russell A. 
Published: October 2017

AbstractDental practitioners often require patients to perform specific mandibular movements (protrusive, retrusive, and lateral) in order to make centric relation and eccentric records. Occasionally, patients are unable to comprehend and perform the desired movements, even after repeated instructions. This article describes a quick, simple, and easy‐to‐follow technique to help guide patients with their mandibular movements.
The life story from age 26 to 32: Rank‐order stability and mean‐level change
Authors: Sengsavang Sonia , Pratt Michael W. , Alisat Susan , Sadler Pamela 
Published: October 2017

AbstractObjectiveIn this longitudinal, mixed‐methods project, the primary focus was to examine the rank‐order stability and mean‐level change in the life story during the period of emerging adulthood to young adulthood, while also investigating how the transition to parenthood may impact the life story.MethodSeventy‐two participants described three key life story scenes at age 26 and again at 32 (28% attrition from age 26 to 32). The narratives were coded for a range of features, including motivational themes (agency, communion), affective themes (emotional tone), an integrative meaning theme (coherent positive resolution), and a structural property (narrative complexity).ResultsOverall, there was moderate temporal stability and mean‐level increase in several features of narrative identity over this key period. Positive changes in communion levels and overall emotional tone of life story scenes were especially evident for new parents at age 32.ConclusionsThese longitudinal results suggested that adopting new social roles, in this case becoming a parent, predicted how the life story was expressed, just as they seemed to influence other levels of personality, such as traits, following the social investment principle.
Baccharis dracunculifolia DC (Asteraceae) selectively modulates the effector functions of human neutrophils
Authors: Figueiredo-Rinhel Andréa S G , de Melo Lamartine L , Bortot Leandro O , Santos Everton O L , Andrade Micássio F , Azzolini Ana Elisa C S , Kabeya Luciana M , Caliri Antonio , Bastos Jairo K , Lucisano-Valim Yara Maria 
Published: October 2017

Abstract

Objectives
To examine whether the hydroalcoholic extract from Baccharis dracunculifolia leaves (BdE) modulates the human neutrophil oxidative metabolism, degranulation, phagocytosis and microbial killing capacity.

Methods
In-vitro assays based on chemiluminescence, spectrophotometry, flow cytometry and polarimetry were used, as well as docking calculations.

Key findings
At concentrations that effectively suppressed the neutrophil oxidative metabolism elicited by soluble and particulate stimuli (&lt;10 μg/ml), without clear signs of cytotoxicity, BdE (1) inhibited NADPH oxidase and myeloperoxidase activity; (2) scavenged H2O2 and HOCl; (3) weakly inhibited phagocytosis; and (4) did not affect neutrophil degranulation and microbial killing capacity, the expression levels of TLR2, TLR4, FcγRIIa, FcγRIIIb and CR3 and the activity of elastase and lysozyme. Caffeic acid, one of the major B. dracunculifolia secondary metabolites, did not inhibit phagocytosis but interfered in the myeloperoxidase–H2O2–HOCl system by scavenging H2O2 and HOCl, and interacting with the catalytic residues His-95, Arg-239 and Gln-91.

Conclusions
BdE selectively modulates the effector functions of human neutrophils, inhibits the activity of key enzymes and scavenges physiological oxidant species. Caffeic acid contributes to lower the levels of oxidant species. Our findings help to unravel the mechanisms by which these natural products exert immunomodulatory action towards neutrophils.
Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats
Authors: Wang Weifeng , Ha Chengzhi , Lin Tao , Wang Dawei , Wang Yuanhe , Gong Mingzhi 
Published: October 2017

Abstract

Objectives
Celastrol has attracted wide interests for its anticancer and anti-inflammation properties, and studies have demonstrated that celastrol negatively modulates the stromal cell-derived factor-1 (SDF-1) and receptor C-X-C chemokine receptor type 4 (CXCR4) signalling. We aim in this study to investigate the effects of celastrol in osteoarthritis (OA) in vivo and explored the underlying molecular mechanisms.

Methods
We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments. We further assessed the alterations of the SDF-1/CXCR4 pathway and cartilage-specific genes, at both mRNA and protein levels.

Key findings
Celastrol significantly attenuated the joint pain and cartilage damage induced by MIA in OA rats and suppressed the upregulation of SDF-1/CXCR4 and associated genes caused by MIA injections. Furthermore, MIA induced a decrease in cartilage-specific genes which was also prevented by celastrol treatments.

Conclusions
Celastrol ameliorate OA in vivo as evidenced by the attenuated joint pain and less cartilage damage in OA rats given celastrol treatments, an effect mediated via suppression of the SDF-1/CXCR4 pathway.
Nutritional evaluation of the legume Macrotyloma axillare using in vitro and in vivo bioassays in sheep
Authors: Lima P. M. T. , Moreira G. D. , Sakita G. Z. , Natel A. S. , Mattos W. T. , Gimenes F. M. A. , Gerdes L. , McManus C. , Abdalla A. L. , Louvandini H. 
Published: October 2017

SummaryThis study consisted of two experiments with the following objectives: to evaluate the effects of tannins from the tropical legume macrotiloma (Macrotyloma axillare) on total gas and methane (CH4) production, as well as on ruminal fermentation parameters by performing an in vitro bioassay, with samples incubated with and without polyethylene glycol (PEG) in a semi‐automatic system; and secondly in a 17 day in vivo experiment, to determine apparent total tract digestibility (ATTD) of dietary nutrients and ruminal fermentation parameters of 12 intact 8‐ to 9‐month‐old Santa Inês (averaging 24.95 ± 1.8 kg body weight) ewes fed tropical grass hay supplemented with macrotiloma hay. The ewes were divided into two treatment groups depending on their diet: chopped aruana grass hay (Panicum maximum cv. Aruana) (control—CON); and aruana grass hay supplemented with chopped macrotiloma hay (macrotiloma—MAC). The animals were kept for 5 consecutive days in metabolic cages for the ATTD assay, and at the end of this period, samples of rumen fluid were collected from each ewe to determine ammoniacal nitrogen (NH3‐N) and short‐chain fatty acid (SCFA) production, and protozoa count. For the in vitro assay, a decrease in total gas and CH4 production was observed for samples incubated without PEG (p < .05). No differences were observed for the other parameters evaluated (p > .05). In the in vivo experiment, increased intake and ATTD of crude protein were observed for the animals fed MAC when compared to CON (p < .05). For rumen fermentation parameters, increased NH3‐N, total SCFA and isobutyrate concentrations, as well as reduced protozoa count were observed for MAC when compared to CON (p < .05). The results observed here indicated the potential of macrotiloma for use as a ruminant feed, and antimethanogenic potential of this plant was noted.
Can Cyber‐Physical Systems Reliably Collaborate within a Blockchain?
Authors: van Lier Ben 
Published: October 2017

AbstractA blockchain can be considered a technological phenomenon that is made up of different interconnected and autonomous systems. Such systems are referred to here as cyber‐physical systems: complex interconnections of cyber and physical components. When cyber‐physical systems are interconnected, a new whole consisting of a system of systems is created by the autonomous systems and their intercommunication and interaction. In a blockchain, individual systems can independently make decisions on joint information transactions. The decision‐making procedures needed for this are executed based on fault‐tolerant communication and voting and consensus procedures, while the results of these decision‐making procedures are stored in distributed ledgers. Due to the intercommunication, interaction, and independent decision making by autonomous systems, the new whole of a blockchain is a complex entity. Complexity science rather than the usual reductionist scientific approach can help us better understand the behaviour of the new and continuously developing whole of a blockchain as a technological phenomenon.
Blockchain Technology as an Institution of Property
Authors: Ishmaev G. 
Published: October 2017

AbstractThis paper argues that the practical implementation of blockchain technology can be considered an institution of property similar to legal institutions. Invoking Penner's theory of property and Hegel's system of property rights, and using the example of bitcoin, it is possible to demonstrate that blockchain effectively implements all necessary and sufficient criteria for property without reliance on legal means. Blockchains eliminate the need for a third‐party authority to enforce exclusion rights, and provide a system of universal access to knowledge and discoverability about the property rights of all participants and how the system functions. The implications of these findings are that traditional property relations in society could be replaced by or supplemented with blockchain models, and implemented in new domains.
Clinicomanometric factors associated with clinically relevant esophagogastric junction outflow obstruction from the Sandhill high‐resolution manometry system
Authors: Song B. G. , Min Y. W. , Lee H. , Min B.‐H. , Lee J. H. , Rhee P.‐L. , Kim J. J. 
Published: October 2017

AbstractBackgroundIntegrated relaxation pressure (IRP) is a key metric for diagnosing esophagogastric junction outflow obstruction (EGJOO). However, its normal value might be different according to the manufacturer of high‐resolution manometry (HRM). This study aimed to investigate optimal value of IRP for diagnosing EGJOO in Sandhill HRM and to find clinicomanometric variables to segregate clinically relevant EGJOO.MethodsWe analyzed 262 consecutive subjects who underwent HRM between June 2011 and December 2016 showing elevated median IRP (> 15 mm Hg) but did not satisfy criteria for achalasia. Clinically relevant subjects were defined as follows: (i) subsequent HRM met achalasia criteria during follow‐up (early achalasia); (ii) Eckardt score was decreased at least two points without exceeding a score of 3 after pneumatic dilatation (variant achalasia); and (iii) significant passage disturbance on esophagogram without structural abnormality (possible achalasia).Key ResultsSeven subjects were clinically relevant, including two subjects with early achalasia, four subjects with variant achalasia, and one subject with possible achalasia. All clinically relevant subjects had IRP 20 mm Hg or above. Among subjects (n = 122) with IRP 20 mm Hg or more, clinically relevant group (n = 7) had significantly higher rate of dysphagia (100% vs 24.3%, P < .001) and compartmentalized pressurization (85.7% vs 21.7%, P = .001) compared to clinically non‐relevant group (n = 115).Conclusions & InferencesOur results suggest that IRP of 20 mm Hg or higher could segregate clinically relevant subjects showing EGJOO in Sandhill HRM. Additionally, if subjects have both dysphagia and compartmentalized pressurization, careful follow‐up is essential.
Implantable cardioverter‐defibrillator in the elderly: Predictors of appropriate interventions and mortality at 12‐month follow‐up
Authors: Ferretto Sonia , Zorzi Alessandro , Dalla Valle Chiara , Migliore Federico , Leoni Loira , De Lazzari Manuel , Corrado Domenico , Iliceto Sabino , Bertaglia Emanuele 
Published: October 2017

AbstractBackgroundThe effectiveness of implantable cardioverter‐defibrillator (ICD) in the elderly is uncertain, given their competing risk of nonarrhythmic death. Guidelines state that an ICD should be implanted if the expectation of survival is at least 1 year. However, survival is not easy to predict in elderly patients with severe cardiac disease.AimTo assess 12‐month survival after ICD implantation in patients aged ≥75 years, to identify predictors of 12‐month mortality, and to evaluate the incidence of ICD therapy during follow‐up.MethodsWe retrospectively analyzed all clinical, instrumental, and survival data of patients ≥75 years old who received an ICD in our center from 2000 to 2013.ResultsWe included 127 patients (mean age 78 years). ICD was implanted for primary prevention in 61%. The 12‐month survival rate was 87.4%. At both univariate and multivariate analyses, left ventricular ejection fraction (EF) ≤ 25%, and moderate to severe impaired renal function (IRF) independently predicted 12‐month mortality that was as high as 45.5% in patients with both risk factors. During a median follow‐up of 38 months, 30 patients (23.6%) received ≥1 appropriate ICD interventions, but only 3.1% of shocks occurred during the first year, and none in the subgroup of patients with EF ≤ 25% and IRF.ConclusionTwelve‐month survival in elderly patients after ICD implantation is good and the indication for ICD should not be based on age alone. However, the subgroup with EF ≤ 25% and IRF showed a high 12‐month nonarrhythmic mortality and did not benefit from ICD implantation.
Hemodynamic parameters and baroreflex sensitivity during head‐up tilt test in patients with neurally mediated syncope
Authors: Lee Sung Ho , Yang Ji Hyun , Yim Hye Ran , Park Jungwae , Park Seung‐Jung , Park Kyoung‐Min , On Young Keun , Kim June Soo 
Published: October 2017

AbstractBackgroundWe aimed to investigate differences in hemodynamic parameters and the role of baroreflex sensitivity (BRS) in patients with a history of neurally mediated syncope (NMS) compared with a control group.MethodsHemodynamic parameters and BRS were continuously measured noninvasively using a Finometer at rest and during passive head‐up tilt test (HUT) in patients with a history of NMS (n = 55) and a control group (n = 77). The tilting period was divided into pretest (resting supine position), initial (first 3 minutes of tilting), last (last 3 minutes of tilting), and recovery (3 minutes after tilting was complete) periods.ResultsDecrease in systolic blood pressure (− 14.7 ± 15.7 mm Hg vs − 7.6 ± 14.3 mm Hg, P < 0.01) was more prominent and increase in total systemic peripheral resistance was significantly smaller (67.6 ± 418.7 dyn.s/cm5 vs 189.4 ± 261.0 dyn.s/cm5, P = 0.04) from the initial to the last period of HUT in the patient group compared with the control group. BRS was significantly higher during the pretest period (20.1 ± 10.9 ms/mm Hg vs 13.0 ± 8.1 ms/mm Hg, P < 0.01) in the patient group, while the decrease in BRS from the pretest to the initial period was greater (−8.5 ± 6.0 ms/mm Hg vs − 3.2 ± 4.1 ms/mm Hg, P = 0.01).ConclusionsDysfunctional BRS in response to orthostatic stress might be involved in pathological autonomic cardiac modulation of NMS.
Correlation of head‐up tilt table test time interval with future risk of recurrent syncope
Authors: Singhania Priti K , Ranwa Bhanwar L. , Gupta Sajal 
Published: October 2017

AbstractBackgroundHead‐up tilt table test (HUTT) is widely used for the investigation of syncope and presyncope. Time required for positive response has a probable relationship to the sensitivity of neural reflex mechanism underlying syncope.MethodsWe evaluated patients with history of syncope. Group A included patients with recurrent syncope defined as two or more episodes of syncope and group B included those with one episode of syncope. Time required for the test to become positive in both the groups was analyzed. Patients with positive HUTT were followed for 1 year.ResultsOf 80 patients, 68 eligible study patients were divided into group A (32.35%) and group B (67.65%). HUTT was positive in 41 patients (positivity rate = 60.29%). Positivity rate was 100% in group A and 41.3% in group B. Median time interval for positive response in groups A and B were 12.5 and 30.0 minutes, respectively. An inverse association was found between recurrent syncope and time interval for positive response (R = − 0.282, P = 0.002). Time interval of less than 19.5 minutes for positive response had 94.5% sensitivity and 97.89% specificity for recurrent syncope. On follow‐up, positive association was found between time interval for positive response less than 19.5 minutes and future recurrence of syncope (odds ratio = 22.75, 95% confidence interval = 4.37–118.34, P = 0.000).ConclusionHUTT time interval of less than 19.5 minutes for positive response predicted future recurrence of syncope. Hence, it may serve as an important predictor of future recurrence of syncope.
Relationship quality influences attitudes toward and perceptions of infidelity
Authors: SILVA ANDRÉ , SARAIVA MAGDA , ALBUQUERQUE PEDRO B. , ARANTES JOANA 
Published: October 2017

AbstractDo attitudes toward and perceptions of infidelity depend on perceived relationship quality? A prediction was made that there should be a positive correlation between perceived relationship quality and negative attitudes and perceptions of infidelity, and that these correlations should be stronger for males than for females. These predictions were confirmed. More specifically, strongly negative evaluations of infidelity were reported by females regardless of relationship quality, and for males with high relationship quality. Negative attitudes toward infidelity increased for both males and females in high‐quality committed relationships, but males who reported lower relationship quality had the most favorable attitudes toward infidelity. These results are consistent with an evolutionary rationale, which suggests that males' attitudes and perceptions of infidelity depend on their perceived risk of cuckoldry.
Autologistic Models for Benchmark Risk or Vulnerability Assessment of Urban Terrorism Outcomes
Authors: Liu Jingyu , Piegorsch Walter W. , Grant Schissler A. , Cutter Susan L. 
Published: October 2017

SummaryWe develop a quantitative methodology to characterize vulnerability among 132 US urban centres (‘cities’) to terrorist events, applying a place-based vulnerability index to a database of terrorist incidents and related human casualties. A centred autologistic regression model is employed to relate urban vulnerability to terrorist outcomes and also to adjust for auto-correlation in the geospatial data. Risk analytic ‘benchmark’ techniques are then incorporated in the modelling framework, wherein levels of high and low urban vulnerability to terrorism are identified. This new translational adaptation of the risk benchmark approach, including its ability to account for geospatial auto-correlation, is seen to operate quite flexibly in this sociogeographic setting.
Differentially Private Model Selection with Penalized and Constrained Likelihood
Authors: Lei Jing , Charest Anne-Sophie , Slavkovic Aleksandra , Smith Adam , Fienberg Stephen 
Published: October 2017

SummaryIn statistical disclosure control, the goal of data analysis is twofold: the information released must provide accurate and useful statistics about the underlying population of interest, while minimizing the potential for an individual record to be identified. In recent years, the notion of differential privacy has received much attention in theoretical computer science, machine learning and statistics. It provides a rigorous and strong notion of protection for individuals’ sensitive information. A fundamental question is how to incorporate differential privacy in traditional statistical inference procedures. We study model selection in multivariate linear regression under the constraint of differential privacy. We show that model selection procedures based on penalized least squares or likelihood can be made differentially private by a combination of regularization and randomization, and we propose two algorithms to do so. We show that our privacy procedures are consistent under essentially the same conditions as the corresponding non-privacy procedures. We also find that, under differential privacy, the procedure becomes more sensitive to the tuning parameters. We illustrate and evaluate our method by using simulation studies and two real data examples.
Estimation of Tail Risk Based on Extreme Expectiles
Authors: Daouia Abdelaati , Girard Stéphane , Stupfler Gilles 
Published: October 2017

SummaryWe use tail expectiles to estimate alternative measures to the value at risk and marginal expected shortfall, which are two instruments of risk protection of utmost importance in actuarial science and statistical finance. The concept of expectiles is a least squares analogue of quantiles. Both are M-quantiles as the minimizers of an asymmetric convex loss function, but expectiles are the only M-quantiles that are coherent risk measures. Moreover, expectiles define the only coherent risk measure that is also elicitable. The estimation of expectiles has not, however, received any attention yet from the perspective of extreme values. Two estimation methods are proposed here, either making use of quantiles or relying directly on least asymmetrically weighted squares. A main tool is first to estimate large values of expectile-based value at risk and marginal expected shortfall within the range of the data, and then to extrapolate the estimates obtained to the very far tails. We establish the limit distributions of both of the resulting intermediate and extreme estimators. We show via a detailed simulation study the good performance of the procedures and present concrete applications to medical insurance data and three large US investment banks.
What Partial Control Might Not Tell Us about Agreement: A Reply to Landau
Authors: Grano Thomas 
Published: October 2017

AbstractLandau (2016b) draws on data from person mismatches in partial control to argue that agreement is (at least sometimes) a PF (Phonological Form) phenomenon. The argument depends in part on the premise that there is a reading of sentences such asThey wanted to prepare themselves and then meet for debatethat corresponds to a structure in which the VPmeet for debatehas a controlled PRO subject that is semantically first‐person but morphologically third‐person. I argue that according to Landau's own assumptions, PRO in such sentences is not semantically first‐person at any level of representation: Landau's premise relies on a problematic conflation between PRO and the output obtained by applying the group operator to PRO in Landau's approach to partial control. Consequently, Landau's argument for the PF status of agreement does not go through.