bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of a Surgical Safety Checklist to Improve Team Communication
Authors: Cabral Richard A. , Eggenberger Terry , Keller Kathryn , Gallison Barry S. , Newman David 
Published: August 2016

AbstractTo improve surgical team communication, a team at Broward Health Imperial Point Hospital, Ft Lauderdale, Florida, implemented a program for process improvement using a locally adapted World Health Organization Surgical Safety Checklist. This program included a standardized, comprehensive time out and a briefing/debriefing process. Postimplementation responses to the Safety Attitudes Questionnaire revealed a significant increase in the surgical team's perception of communication compared with that reported on the pretest (6% improvement resulting in t79 = –1.72, P < .05, d = 0.39). Perceptions of communication increased significantly for nurses (12% increase, P = .002), although the increase for surgeons and surgical technologists was lower (4% for surgeons, P = .15 and 2.3% for surgical technologists, P = .06). As a result of this program, we have observed improved surgical teamwork behaviors and an enhanced culture of safety in the OR.
Back to Basics: Preventing Surgical Fires
Authors: Spruce Lisa 
Published: August 2016

AbstractWhen fires occur in the OR, they are devastating and potentially fatal to both patients and health care workers. Fires can be prevented by understanding the fire triangle and methods of reducing fire risk, conducting fire risk assessments, and knowing how to respond if a fire occurs. This Back to Basics article addresses the basics of fire prevention and the steps that can be taken to prevent fires from occurring.
Clinical Issues‐September 2016
Authors: Van Wicklin Sharon A. 
Published: August 2016

This MonthPackaging multiple items in a single peel pouchKey words: peel pouch, packaging, low profile items.Closed instruments found in instrument traysKey words: closed instruments, instrument trays.Organic and inorganic material found in instrument traysKey words: organic material, inorganic material, instrument trays.Processed endoscopes touching each otherKey words: endoscope storage, endoscopes touching, endoscope storage cabinet, endoscope damage, endoscope coiling.Maximum safe storage time for processed flexible endoscopesKey words: endoscope storage, endoscope storage time, risk assessment, multidisciplinary team.
Task- and Talker-Specific Gains in Auditory Training
Authors: Barcroft Joe , Spehar Brent , Tye-Murray Nancy , Sommers Mitchell 
Published: August 2016

Purpose
This investigation focused on generalization of outcomes for auditory training by examining the effects of task and/or talker overlap between training and at test.

Method
Adults with hearing loss completed 12 hr of meaning-oriented auditory training and were placed in a group that trained on either multiple talkers or a single talker. A control group also completed 12 hr of training in American Sign Language. The experimental group’s training included a 4-choice discrimination task but not an open-set sentence test. The assessment phase included the same 4-choice discrimination task and an open-set sentence test, the Iowa Sentences Test (Tyler, Preece, & Tye-Murray, 1986).

Results
Improvement on 4-choice discrimination was observed in the experimental group as compared with the control group. Gains were (a) highest when the task and talker were the same between training and assessment; (b) second highest when the task was the same but the talker only partially so; and (c) third highest when task and talker were different.

Conclusions
The findings support applications of transfer-appropriate processing to auditory training and favor tailoring programs toward the specific needs of the individuals being trained for tasks, talkers, and perhaps, for stimuli, in addition to other factors.
Auditory Training With Frequent Communication Partners
Authors: Tye-Murray Nancy , Spehar Brent , Sommers Mitchell , Barcroft Joe 
Published: August 2016

Purpose
Individuals with hearing loss engage in auditory training to improve their speech recognition. They typically practice listening to utterances spoken by unfamiliar talkers but never to utterances spoken by their most frequent communication partner (FCP)—speech they most likely desire to recognize—under the assumption that familiarity with the FCP's speech limits potential gains. This study determined whether auditory training with the speech of an individual's FCP, in this case their spouse, would lead to enhanced recognition of their spouse's speech.

Method
Ten couples completed a 6-week computerized auditory training program in which the spouse recorded the stimuli and the participant (partner with hearing loss) completed auditory training that presented recordings of their spouse.

Results
Training led participants to better discriminate their FCP's speech. Responses on the Client Oriented Scale of Improvement (Dillon, James, & Ginis, 1997) indicated subjectively that training reduced participants' communication difficulties. Peformance on a word identification task did not change.

Conclusions
Results suggest that auditory training might improve the ability of older participants with hearing loss to recognize the speech of their spouse and might improve communication interactions between couples. The results support a task-appropriate processing framework of learning, which assumes that human learning depends on the degree of similarity between training tasks and desired outcomes.
Generic phase diagram of binary superlattices
Authors: Tkachenko Alexei V. 
Published: August 2016

Significance
Self-assembled superlattices represent one of the most promising trends in current nano- and colloidal sciences. Their potential applications range from photonics and plasmonics to catalysis and biomedical devices. This paper introduces a simple but general and remarkably rich theoretical model that provides an explanation for the observed morphological diversity and high degree of universality in superlattice self-assembly. The model describes binary system of mutually attractive sticky spheres of different sizes. An intuitive geometric procedure is used for constructing the phase diagram at variable composition and size ratio. The great conceptual value of this model is combined with its potential for predicting phase behavior for a broad range of self-assembly scenarios: DNA mediated, electrostatically driven, or induced by controlled drying.
FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in
Arabidopsis
Authors: Chen Jia , Yu Feng , Liu Ying , Du Changqing , Li Xiushan , Zhu Sirui , Wang Xianchun , Lan Wenzhi , Rodriguez Pedro L. , Liu Xuanming , Li Dongping , Chen Liangbi , Luan Sheng 
Published: August 2016

Significance
Receptor-like kinase FERONIA (FER) not only serves as a receptor for growth-regulating rapid alkalinization factor (RALF) peptide but also acts as an important node in a variety of other signaling pathways, including plant responses to hormones, pathogens, and abiotic stresses. However, the mechanism underlying FER actions in these signaling cross-talks remain largely unknown. Our previous work identified a molecular relay that allows FER to inhibit abscisic acid (ABA) response through activation of a small G protein to enhance the activity of the clade A protein phosphatase type 2C (PP2C) ABA Insensitive 2 (ABI2), a repressor of ABA response. In this study, we found that ABI2 can directly interact and dephosphorylate FER, providing a feedback mechanism for RALF activation of FER.
MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation
Authors: Anderson Sarah , Poudel Kumud Raj , Roh-Johnson Minna , Brabletz Thomas , Yu Ming , Borenstein-Auerbach Nofit , Grady William N. , Bai Jihong , Moens Cecilia B. , Eisenman Robert N. , Conacci-Sorrell Maralice 
Published: August 2016

Significance
The MYC family of transcription factors is deregulated in a broad range of cancers and drives the expression of genes that mediate biomass accumulation and promote cell proliferation and tumor initiation. We find that MYC can also trigger tumor cell migration and metastasis independently of its transcriptional activity, via its conversion to MYC-nick, a truncated form of MYC localized in the cytoplasm. MYC-nick promotes reorganization of the actin cytoskeleton by inducing expression of the actin-bundling protein fascin and by activating the Rho GTPase Cdc42, both of which lead to formation of filopodia, cellular structures known to drive cell migration. Our work links the repurposing of the MYC transcription factor to altered cytoskeletal structure and tumor cell metastatic behavior.
The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome
Authors: Krajcoviechova Alena , Tremblay Johanne , Wohlfahrt Peter , Bruthans Jan , Tahir Muhmmad Ramzan , Hamet Pavel , Cifkova Renata 
Published: August 2016

BACKGROUND
The impact of metabolic phenotypes on the association of uricemia with urinary albumin/creatinine ratio (uACR) remains unresolved. We evaluated the association between serum uric acid and uACR in persons with 0, and 1–2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association.

METHODS
Using data from a cross-sectional survey of a representative Czech population aged 25–64 years (n = 3612), we analyzed 1,832 persons without decreased glomerular filtration rate &lt;60ml/min/1.73 m2, diabetes, and MetS. MetS components were defined using the joint statement of the leading societies.

RESULTS
Of the 1,832 selected participants, 64.1% (n = 1174) presented with 1–2 MetS components (age 46.3±11.2; men 51.7%), whereas 35.9% (n = 658) were free of any component (age 39.4±10.0; men 34.2 %). In fully adjusted multiple linear regression models for uricemia, uACR was an independent factor for increase in uric acid levels only in persons with 1–2 MetS components (standardized beta (Sβ) 0.048; P = 0.024); however, not in those without any component (Sβ 0.030; P = 0.264). Uric acid levels increased by the interaction of uACR with VAI (Sβ 0.06; P = 0.012), and of uACR with MAP (Sβ 0.05; P = 0.009). Finally, the association of uACR with uricemia was confined to persons whose VAI together with MAP were ≥the median of 1.35 and 98mm Hg, respectively (Sβ 0.190; P &lt; 0.001).

CONCLUSIONS
We demonstrated a strong modification effect of VAI and MAP on the association between uACR and uricemia, which suggests obesity-related hypertension as the underlying mechanism.
A likelihood ratio-based method to predict exact pedigrees for complex families from next-generation sequencing data
Authors: Heinrich Verena , Kamphans Tom , Mundlos Stefan , Robinson Peter N , Krawitz Peter M 
Published: August 2016

Abstract

Motivation
Next generation sequencing technology considerably changed the way we screen for pathogenic mutations in rare Mendelian disorders. However, the identification of the disease-causing mutation amongst thousands of variants of partly unknown relevance is still challenging and efficient techniques that reduce the genomic search space play a decisive role. Often segregation- or linkage analysis are used to prioritize candidates, however, these approaches require correct information about the degree of relationship among the sequenced samples. For quality assurance an automated control of pedigree structures and sample assignment is therefore highly desirable in order to detect label mix-ups that might otherwise corrupt downstream analysis.

Results
We developed an algorithm based on likelihood ratios that discriminates between different classes of relationship for an arbitrary number of genotyped samples. By identifying the most likely class we are able to reconstruct entire pedigrees iteratively, even for highly consanguineous families. We tested our approach on exome data of different sequencing studies and achieved high precision for all pedigree predictions. By analyzing the precision for varying degrees of relatedness or inbreeding we could show that a prediction is robust down to magnitudes of a few hundred loci.

Availability and Implementation
A java standalone application that computes the relationships between multiple samples as well as a Rscript that visualizes the pedigree information is available for download as well as a web service at www.gene-talk.de.

Supplementary information
Supplementary data are available at Bioinformatics online.
Imbalanced multi-label learning for identifying antimicrobial peptides and their functional types
Authors: Lin Weizhong , Xu Dong 
Published: August 2016

Motivation: With the rapid increase of infection resistance to antibiotics, it is urgent to find novel infection therapeutics. In recent years, antimicrobial peptides (AMPs) have been utilized as potential alternatives for infection therapeutics. AMPs are key components of the innate immune system and can protect the host from various pathogenic bacteria. Identifying AMPs and their functional types has led to many studies, and various predictors using machine learning have been developed. However, there is room for improvement; in particular, no predictor takes into account the lack of balance among different functional AMPs.
Results: In this paper, a new synthetic minority over-sampling technique on imbalanced and multi-label datasets, referred to as ML-SMOTE, was designed for processing and identifying AMPs’ functional families. A novel multi-label classifier, MLAMP, was also developed using ML-SMOTE and grey pseudo amino acid composition. The classifier obtained 0.4846 subset accuracy and 0.16 hamming loss.
Availability and Implementation: A user-friendly web-server for MLAMP was established at http://www.jci-bioinfo.cn/MLAMP.
Contacts: linweizhong@jci.edu.cn or xudong@missouri.edu
Disrupting ER-associated protein degradation suppresses the abscission defect of a weak hae hsl2 mutant in Arabidopsis
Authors: Baer John , Taylor Isaiah , Walker John C. 
Published: August 2016

Abstract
In Arabidopsis thaliana , the process of abscission, or the shedding of unwanted organs, is mediated by two genes, HAESA ( HAE ) and HAESA-LIKE 2 ( HSL2 ), encoding receptor-like protein kinases (RLKs). The double loss-of-function mutant hae-3 hsl2-3 is completely deficient in floral abscission, but, interestingly, the hae-3 hsl2-9 mutant displays a less severe defect. This mutant was chosen for an ethyl methanesulfonate (EMS) screen to isolate enhancer and suppressor mutants, and two such suppressors are the focus of this study. Pooled DNA from the F 2 generation of a parental backcross was analyzed by genome sequencing to reveal candidate genes, two of which complement the suppressor phenotype. These genes, EMS-MUTAGENIZED BRI1 SUPPRESSOR 3 ( EBS3 ) and EBS4 , both encode mannosyltransferases involved in endoplasmic reticulum (ER)-associated degradation (ERAD) of proteins. Further analysis of these suppressor lines revealed that suppressor mutations are acting solely on the partially functional hsl2-9 mutant receptor to modify the abscission phenotype. Expressing a hsl2-9–yellow fluorescent protein (YFP) transgene in ebs3 mutants yields a higher fluorescent signal than in EBS3 / ebs3, suggesting that these mutants restore abscission by disrupting ERAD to allow accumulation of the hsl2-9 receptor, which probably escapes degradation to be trafficked to the plasma membrane to regain signaling.
Detection of burning ashes from thermonuclear X-ray bursts
Authors: Kajava J. J. E. , Nättilä J. , Poutanen J. , Cumming A. , Suleimanov V. , Kuulkers E. 
Published: August 2016

Abstract
When neutron stars (NS) accrete gas from low-mass binary companions, explosive nuclear burning reactions in the NS envelope fuse hydrogen and helium into heavier elements. The resulting thermonuclear (type-I) X-ray bursts produce energy spectra that are fit well with black bodies, but a significant number of burst observations show deviations from Planck spectra. Here we present our analysis of RXTE/PCA observations of X-ray bursts from the NS low-mass X-ray binary HETE J1900.1-2455. We have discovered that the non-Planckian spectra are caused by photoionization edges. The anticorrelation between the strength of the edges and the colour temperature suggests that the edges are produced by the nuclear burning ashes that have been transported upwards by convection and become exposed at the photosphere. The atmosphere model fits show that occasionally the photosphere can consist entirely of metals, and that the peculiar changes in blackbody temperature and radius can be attributed to the emergence and disappearance of metals in the photosphere. As the metals are detected already in the Eddington-limited phase, it is possible that a radiatively driven wind ejects some of the burning ashes into the interstellar space.
Single molecule tracking of Ace1p in Saccharomyces cerevisiae defines a characteristic residence time for non-specific interactions of transcription factors with chromatin
Authors: Ball David A , Mehta Gunjan D , Salomon-Kent Ronit , Mazza Davide , Morisaki Tatsuya , Mueller Florian , McNally James G , Karpova Tatiana S 
Published: August 2016

AbstractIn vivo single molecule tracking has recently developed into a powerful technique for measuring and understanding the transient interactions of transcription factors (TF) with their chromatin response elements. However, this method still lacks a solid foundation for distinguishing between specific and non-specific interactions. To address this issue, we took advantage of the power of molecular genetics of yeast. Yeast TF Ace1p has only five specific sites in the genome and thus serves as a benchmark to distinguish specific from non-specific binding. Here, we show that the estimated residence time of the short-residence molecules is essentially the same for Hht1p, Ace1p and Hsf1p, equaling 0.12–0.32 s. These three DNA-binding proteins are very different in their structure, function and intracellular concentration. This suggests that (i) short-residence molecules are bound to DNA non-specifically, and (ii) that non-specific binding shares common characteristics between vastly different DNA-bound proteins and thus may have a common underlying mechanism. We develop new and robust procedure for evaluation of adverse effects of labeling, and new quantitative analysis procedures that significantly improve residence time measurements by accounting for fluorophore blinking. Our results provide a framework for the reliable performance and analysis of single molecule TF experiments in yeast.
Feasibility and efficacy of an extended trial of home-based working memory training for pediatric brain tumor survivors: a pilot study
Authors: Carlson-Green Bonnie , Puig Jennifer , Bendel Anne 
Published: August 2016

AbstractBackground.Impaired working memory appears to play a key role in some of the neurocognitive late effects of pediatric brain tumor treatments, including declines in intellectual and executive functioning. Recent studies of pediatric cancer survivors suggest Cogmed® Working Memory Training is effective at improving working memory, although pediatric brain tumor survivors may demonstrate a less robust response than children with other cancers. The current study sought to determine if an extended course of Cogmed (35 sessions) was both feasible and efficacious for brain tumor survivors and if improvements were observable in near-transfer and far-transfer working memory measures as well as parent rating scores at 6 months post-treatment.Methods.Twenty pediatric brain tumor survivors ages 8 to 18 years with working memory deficits completed 35 sessions of Cogmed. Assessments of working memory and academic skills were completed at baseline, completion of training, and 6-month follow-up and parents completed questionnaires at baseline and 6-month follow-up.Results.Participants showed significant improvements in working memory at training completion and 6-month follow-up and math achievement at 6-month follow-up. Parents reported executive functioning improvements at follow-up as compared with baseline. Participants’ program-based working memory skills did not change significantly between sessions 25 and 35, suggesting that extended training did not provide additional benefit.Conclusions.This study replicates and extends previous research by: (1) demonstrating that brain tumor survivors at high risk for neurocognitive late effects can complete and benefit from working memory training, (2) identifying a point of diminished returns on training time investment, and (3) demonstrating benefits 6 months post-intervention.
Pivotal therapeutic trials for infiltrating gliomas and how they affect clinical practice
Authors: Lukas Rimas V , Mrugala Maciej M 
Published: August 2016

Abstract
The therapeutic landscape of the management of low- and high-grade infiltrating gliomas continues to evolve. Daily clinical decision making in neuro-oncology clinics across the US is frequently challenging, especially for anaplastic and low grade primary brain tumors. The focus of this review is centered on treatments which are approved by the FDA and/or featured in the NCCN Guidelines. Systemic therapy trials using a variety of agents such as temozolomide, bevacizumab, and procarbazine, lomustine, vincristine (PCV), and lastly trials of local therapies including surgical trials using carmustine impregnated wafers as well as trials investigating the administration of tumor treating fields are evaluated. Pivotal trials on the treatment of the primary brain tumors are discussed in detail along with associated correlative studies.
Low-dose Dexmedetomidine Improves Sleep Quality Pattern in Elderly Patients after Noncardiac Surgery in the Intensive Care Unit
Authors: Wu Xin-Hai , Cui Fan , Zhang Cheng , Meng Zhao-Ting , Wang Dong-Xin , Ma Jing , Wang Guang-Fa , Zhu Sai-Nan , Ma Daqing 
Published: August 2016

Abstract

Background
Patients admitted to the intensive care unit (ICU) after surgery often develop sleep disturbances. The authors tested the hypothesis that low-dose dexmedetomidine infusion could improve sleep architecture in nonmechanically ventilated elderly patients in the ICU after surgery.

Methods
This was a pilot, randomized controlled trial. Seventy-six patients age 65 yr or older who were admitted to the ICU after noncardiac surgery and did not require mechanical ventilation were randomized to receive dexmedetomidine (continuous infusion at a rate of 0.1 μg kg−1 h−1; n = 38) or placebo (n = 38) for 15 h, i.e., from 5:00 pm on the day of surgery until 8:00 am on the first day after surgery. Polysomnogram was monitored during the period of study-drug infusion. The primary endpoint was the percentage of stage 2 non–rapid eye movement (stage N2) sleep.

Results
Complete polysomnogram recordings were obtained in 61 patients (30 in the placebo group and 31 in the dexmedetomidine group). Dexmedetomidine infusion increased the percentage of stage N2 sleep from median 15.8% (interquartile range, 1.3 to 62.8) with placebo to 43.5% (16.6 to 80.2) with dexmedetomidine (difference, 14.7%; 95% CI, 0.0 to 31.9; P = 0.048); it also prolonged the total sleep time, decreased the percentage of stage N1 sleep, increased the sleep efficiency, and improved the subjective sleep quality. Dexmedetomidine increased the incidence of hypotension without significant intervention.

Conclusions
In nonmechanically ventilated elderly patients who were admitted to the ICU after noncardiac surgery, the prophylactic low-dose dexmedetomidine infusion may improve overall sleep quality.