bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Tumor Volume Assessed by 18F FDG–PET CT Scan as a Predictive Biomarker for Immune Checkpoint Blockers in Advanced NSCLC and Its Biological Correlates
Authors: Dall’Olio Filippo G. , Zrafi Wael , Roelants Veronique , Ambrosini Valentina , Fourquet Aloyse , Mitea Cristina , Passiglia Francesco , Bauckneht Matteo , Bonardel Gerald , Conci Nicole , Benitez Jose Carlos , Arena Vincenzo , Namour Céline , Naigeon Marie , Monnet Isabelle , Beshiri Kristi , Hoton Delphine , Dursun Safiye , Danlos François Xavier , Argalia Giulia , Aldea Mihaela , Rovera Guido , Derosa Lisa , Iebba Valerio , Gietema Hester A. , Gounant Valerie , Lacroix Valérie , Remon Jordi , Gautheret Daniel , Chaput Nathalie , Job Bastien , Kannouche Patricia L. , Velasco-Nuño Monica , Zitvogel Laurence , Cella Eugenia , Chícharo de Freitas José Reinaldo , Vasseur Damien , Bettaieb Mohamed Aymen , Tagliamento Marco , Hendriks Lizza , Italiano Antoine , Planchard David , Marabelle Aurelien , Barlesi Fabrice , Novello Silvia , De Andreis Desiree , Aboubakar Nana Frank , Ardizzoni Andrea , Zalcman Gerard , Garcia Camilo , Besse Benjamin 
Published: October 2024

Abstract

Purpose:
This study aimed to explore metabolic tumor volume (MTV) as assessed by 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG–PET/CT) and understand its biological meaning in patients with non–small cell lung cancer (NSCLC) exposed to immune checkpoint blockers (ICB).

Experimental Design:
In this study, patients with advanced NSCLC and a positive PET scan within 42 days of first-line treatment were enrolled in 11 institutions across four countries. Total MTV (tMTV) was analyzed, with a 42% maximum standardized uptake value threshold. Survival was analyzed according to high tMTV (≥median). Plasma proteomic profile, whole exome, transcriptome, and other analyses were performed on monocentric cohorts to explore its biological correlates.

Results:
Of the 518 patients included, 167 received ICBs, 257 had chemotherapy plus ICBs, and 94 had chemotherapy. Median tMTV was 99 cm3. Median overall survival (OS) for patients with high tMTV treated with ICBs was 11.4 vs. 29.6 months (P &lt; 0.0012) for those with low tMTV. In patients who received chemotherapy–ICB, tMTV did not correlate with OS (P = 0.099). In patients with programmed death-ligand 1 (PD-L1) ≥1% and high tMTV, chemotherapy–ICB combination was associated with longer OS compared with ICBs alone (20 vs. 11.4 months; P = 0.026), while no survival differences were observed in the low tMTV group. High tMTV correlated (and its detrimental effect seems to be driven) with a specific proteomic profile and increase in genomic instability.

Conclusions:
Our analysis indicates high tMTV is linked to an increase in systemic inflammation, specific cytokines production, and chromosomal instability. tMTV may serve as one of the biomarkers to select the best upfront strategy in patients with PD-L1–positive advanced NSCLC.
First-in-Human Dose-Escalation Study of the First-in-Class PDE3A–SLFN12 Complex Inducer BAY 2666605 in Patients with Advanced Solid Tumors Coexpressing SLFN12 and PDE3A
Authors: Papadopoulos Kyriakos P. , McKean Meredith , Goldoni Silvia , Genvresse Isabelle , Garrido Marine F. , Li Rui , Wilkinson Gary , Kneip Christoph , Yap Timothy A. 
Published: October 2024

Abstract

Purpose:
The study aims to evaluate the safety, tolerability, and pharmacokinetics of BAY 2666605, a velcrin that induces complex formation between the phosphodiesterase PDE3A and the protein Schlafen 12 (SLFN12), leading to a cytotoxic response in cancer cells.

Patients and Methods:
This was a first-in-human phase I study of BAY 2666605 (NCT04809805), an oral, potent first-in-class PDE3A–SLFN12 complex inducer, with reduced PDE3A inhibition. Adults with advanced solid tumors that coexpress SLFN12 and PDE3A received BAY 2666605 at escalating doses starting at 5 mg once daily in 28-day cycles. Forty-seven patients were prescreened for SLFN12 and PDE3A overexpression, and five biomarker-positive patients received ≥1 BAY 2666605 dose.

Results:
The most common adverse event was grade 3 to 4 thrombocytopenia in three of the five patients treated. The long half-life (&gt;360 hours) and associated accumulation of BAY 2666605 led to the selection of an alternative schedule consisting of a loading dose with a once-daily maintenance dose. The maximum tolerated dose was not established as the highest doses of both schedules were intolerable. No objective responses were observed. Due to the high expression of PDE3A in platelets compared with tumor tissues, the ex vivo dose-dependent inhibitory effect of BAY 2666605 on megakaryocytes, and the pharmacokinetic profile of the compound, alternative schedules were not predicted to ameliorate the mechanism-based thrombocytopenia.

Conclusions:
Despite the decreased PDE3A enzymatic inhibition profile of BAY 2666605, the occurrence of thrombocytopenia in treated patients, an on-target effect of the compound, precluded the achievement of a therapeutic window, consequently leading to trial termination.
Serial Optical Coherence Tomography Assessment of Coronary Atherosclerosis and Long‐Term Clinical Outcomes
Authors: Yamaji Kyohei , Kanenawa Kenji , Morofuji Toru , Nishikawa Ryusuke , Imada Kazuaki , Kohjitani Hirohiko , Watanabe Hiroki , Tazaki Junichi , Taniwaki Masanori , Koga Seiji , Akashi Ryohei , Kubo Shunsuke , Ohya Masanobu , Kikuchi Tatsuo , Ohira Hiroshi , Numasawa Yohei , Arikawa Masaya , Iwama Makoto , Kitai Takeshi , Kobayashi Yohei , Shiomi Hiroki , Tada Tomohisa , Yamaji Yuhei , Daidoji Hyuma , Ohtani Hayato , Furukawa Yutaka , Kadota Kazushige , Toyofuku Mamoru , Ando Kenji , Ono Koh , Kimura Takeshi ,   the PREDICTOR investigators
Published: October 2024

Background
The impact of high‐risk coronary artery plaques identified using optical coherence tomography on late luminal narrowing and clinical events remains poorly understood.

Methods and Results

This multicenter prospective study included 176 patients who underwent percutaneous coronary intervention and serial optical coherence tomography at baseline and 1‐year follow‐up to investigate nontarget regions with angiographically intermediate stenosis. At 1 year after percutaneous coronary intervention, the coronary artery lumen area decreased significantly from 6.06 (95% CI, 5.60–6.53) mm
2
to 5.88 (95% CI, 5.41–6.35) mm
2
(difference, −0.18; 95% CI, −0.22 to −0.14 mm
2
;
P
<0.001), particularly in thin‐cap fibroatheromas, thick‐cap fibroatheromas, mixed plaques, and fibrous plaques. The prevalence of fibroatheroma decreased from 38% to 36% (
P
<0.001), whereas calcified plaque increased from 31% to 34% (
P
<0.001), accompanied by a significant increase in calcium thickness and angle. Diabetes and current smoking habits were independently associated with increasing calcium prevalence. Patients with thin‐cap fibroatheroma had a significantly higher 3‐year risk of ischemia‐driven nontarget vessel revascularization (hazard ratio, 2.42 [95% CI, 1.03–5.71];
P
=0.04), primarily due to revascularization in the imaged region. No significant association was observed between coronary artery calcium prevalence and clinical outcomes within 3 years.

Conclusions
The coronary artery lumen area significantly decreased over a 1‐year interval, particularly in thin‐cap fibroatheromas, thick‐cap fibroatheromas, mixed plaques, and fibrous plaques. Although thin‐cap fibroatheroma prevalence was associated with higher risk of ischemia‐driven nontarget vessel revascularization, no significant association was noted between coronary artery calcium prevalence and clinical outcomes within 3 years. The interaction between calcium progression and long‐term clinical events necessitates further investigation.

Registration

URL:
https://www.umin.ac.jp/ctr/
; Unique Identifier: UMIN000031937.
Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE‐TNK Trial Protocol
Authors: Qiu Zhongming , Li Fengli , Xie Dongjing , Yuan Guangxiong , Nguyen Thanh N. , Zhou Kai , Nogueira Raul G. , Saver Jeffrey L. , Campbell Bruce C.V. , Albers Gregory W. , Sang Hongfei , Li Linyu , Tian Yan , Meng Zhaoyou , Wang Duolao , Zi Wenjie , Yang Qingwu ,   the BRIDGE‐TNK investigators
Published: October 2024

Background
Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke. Tenecteplase, a recombinant human tenecteplase tissue‐type plasminogen activator, is a genetically modified variant of alteplase. It is unclear whether the outcomes are different if alteplase is replaced with tenecteplase. This trial aims to determine whether intravenous tenecteplase within 4.5 hours of time last known well confers benefit in patients with acute ischemic stroke with large‐vessel occlusion who undergo endovascular thrombectomy.

Methods
BRIDGE‐TNK (Thrombectomy With Versus Without rhTNK‐tPA in Stroke) is an investigator‐initiated, multicenter, prospective, randomized, open‐label trial with blinded end point evaluation conducted at 40 thrombectomy‐capable centers in China. This trial will randomize 544 patients with intravenous thrombolysis–eligible stroke (272 in each arm) with large‐vessel occlusion within 4.5 hours of last known well to receive bridging intravenous tenecteplase with endovascular thrombectomy (tenecteplase‐plus‐thrombectomy group) or endovascular thrombectomy alone (thrombectomy‐alone group). The primary outcome is the proportion of patients achieving functional independence, defined as a score of 0 to 2 on the modified Rankin Scale, at 90 days. Safety will be assessed via symptomatic intracranial hemorrhage at 48 hours and death at 90 days.

Conclusions
BRIDGE‐TNK will provide important data on the role of intravenous tenecteplase before endovascular thrombectomy in patients with acute ischemic stroke with large‐vessel occlusion who can be treated within 4.5 hours of last known well.

Registration

URL:
https://clinicaltrials.gov
. Unique identifier: NCT04733742.
Consistent activation differences versus differences in consistent activation: Evaluating meta-analytic contrasts
Authors: Küppers Vincent , Cieslik Edna C. , Frahm Lennart , Hoffstaedter Felix , Eickhoff Simon B. , Langner Robert , Müller Veronika I. 
Published: October 2024

Abstract
Meta-analytic contrasts are a promising aspect of coordinate-based meta-analyses in neuroimaging research as they facilitate the statistical comparison of two meta-analytic results. They have been used for a multitude of comparisons, such as task conditions, cognitive processes, and groups. However, it remains to be tested how the results of meta-analytic contrasts relate to those of classic meta-analyses and vice versa. Here, we present a comprehensive empirical investigation of this issue using four datasets from different cognitive domains: working memory, working memory load, cognitive interference processing, and emotional face processing. For all four datasets, we compared the results of a standard meta-analysis across prototypical contrasts (condition A &gt; condition B) reported in individual experiments with those of a contrast between two individual meta-analyses of the same conditions (meta-analysis condition A &gt; meta-analysis condition B). In the meta-analytic contrasts, similar brain regions as in the standard meta-analysis were found but with relatively distinct spatial activation patterns. Additionally, fewer regions were revealed in the meta-analytic contrasts, especially in areas where the conditions spatially overlapped. This can be ascribed to the loss of information on the strength of activations in meta-analytic contrasts, across which standard meta-analysis summarize. In one dataset, additional regions were found in the meta-analytic contrast, potentially due to task effects. Our results demonstrate that meta-analytic contrasts can yield similar results to standard meta-analyses but are sparser. This confirms the overall validity, but also limited ability to capture all regions found in standard meta-analyses. Notable differences observed in some cases indicate that such contrasts cannot be taken as an easy substitute for classic meta-analyses of experiment-level contrasts, warranting further research into the boundary conditions for agreement.
Perceptual, Semantic, and Pragmatic Factors Affect the Derivation of Contrastive Inferences
Authors: Ronderos Camilo R. , Aparicio Helena , Long Madeleine , Shukla Vishakha , Jara-Ettinger Julian , Rubio-Fernandez Paula 
Published: October 2024

Abstract
People derive contrastive inferences when interpreting adjectives (e.g., inferring that ‘the short pencil’ is being contrasted with a longer one). However, classic eye-tracking studies revealed contrastive inferences with scalar and material adjectives, but not with color adjectives. This was explained as a difference in listeners’ informativity expectations, since color adjectives are often used descriptively (hence not warranting a contrastive interpretation). Here we hypothesized that, beyond these pragmatic factors, perceptual factors (i.e., the relative perceptibility of color, material and scalar contrast) and semantic factors (i.e., the difference between gradable and non-gradable properties) also affect the real-time derivation of contrastive inferences. We tested these predictions in three languages with prenominal modification (English, Hindi, and Hungarian) and found that people derive contrastive inferences for color and scalar adjectives, but not for material adjectives. In addition, the processing of scalar adjectives was more context dependent than that of color and material adjectives, confirming that pragmatic, perceptual and semantic factors affect the derivation of contrastive inferences.
Infants Produce Optimally Informative Points to Satisfy the Epistemic Needs of Their Communicative Partner
Authors: Tauzin Tibor , Call Josep , Gergely György 
Published: October 2024

Abstract
Pragmatic theories assume that during communicative exchanges humans strive to be optimally informative and spontaneously adjust their communicative signals to satisfy their addressee’s inferred epistemic needs. For instance, when necessary, adults flexibly and appropriately modify their communicative gestures to provide their partner the relevant information she lacks about the situation. To investigate this ability in infants, we designed a cooperative task in which 18-month-olds were asked to point at the target object they wanted to receive. In Experiment 1, we found that when their desired object was placed behind a distractor object, infants appropriately modified their prototypical pointing to avoid mistakenly indicating the distractor to their partner. When the objects were covered, and their cooperative partner had no information (Experiment 2) or incorrect information (Experiment 3) about the target’s location – as opposed to being knowledgeable about it – infants pointed differentially more often at the target and employed modified pointing gestures more frequently as a function of the amount of relevant information that their partner needed to retrieve their desired object from its correct location. These findings demonstrate that when responding to a verbal request in a cooperative task 18-month-old infants can take into account their communicative partner’s epistemic states and when necessary provide her with the relevant information she lacks through sufficiently informative deictic gestures. Our results indicate that infants possess an early emerging, species-unique cognitive adaptation specialized for communicative mindreading and pragmatic inferential communication which enable the efficient exchange of relevant information between communicating social partners in cooperative contexts.
The Political Economy of Energy Security in Wartime Yemen
Authors: Al-Eryani Abeer 
Published: October 2024

Abstract
The politics of energy provision and the governance of the electricity sector are well-studied topics. However, there is a gap in information when it comes to comprehending how violent conflict interacts with the political economy of the electricity and energy sector. This paper examines the relationship between energy provision and conflict within the context of the ongoing war in Yemen. It illustrates how developments in the conflict trajectory since the war’s onset in 2015 have shaped new forms of energy politics. These developments are reflected in fragmented institutional arrangements, transformed subsidy politics, adaptive grassroots solutions, and emergent war economies, all of which highlight the changing nature of energy security beyond conventional state-centric paradigms. The Yemeni case thus demonstrates an emerging energy landscape in which the sector and war dynamics are deeply intertwined and evolving simultaneously.
An Immediate but Fleeting Interest in MPH Programs After the Onset of COVID-19: An Interrupted Time-Series Analysis
Authors: Bather Jemar R. , Burke Emily M. , Plepys Christine M. , Rajbhandari-Thapa Janani , Furr-Holden Debra , Goodman Melody S. 
Published: October 2024

Objectives: The relationship between the onset of the COVID-19 pandemic and interest in master of public health (MPH) programs is unknown. We examined trends in MPH application rates for 31 MPH concentrations and specifically for the MPH concentration in epidemiology and differences by race and ethnicity before and after the onset of the COVID-19 pandemic. Methods: We constructed a quasi-experimental design to examine trends in MPH application rates from academic years 2015-2016 through 2022-2023 by using Centralized Application Service for Schools and Programs of Public Health data. We used an interrupted time-series analysis to test whether application rates surged after the pandemic’s onset (academic years 2019-2020 through 2020-2021) and whether this increase persisted during the pandemic (academic years 2020-2021 through 2022-2023). We fit models for the overall sample, a combined racially and ethnically minoritized sample, each racial and ethnic group separately, and a non–US citizen sample. Results: The pandemic’s onset correlated with an immediate increase in application rates across most samples: overall (38%) and among American Indian/Alaska Native/Native Hawaiian/Pacific Islander (91%), Asian (35%), Black (42%), Hispanic (60%), multiracial (30%), racially and ethnically minoritized (44%), and White (53%) samples. However, this trend was not sustained; application rate trends during the pandemic were significantly lower than prepandemic trends. Application rate trends for all MPH concentrations and the MPH in epidemiology concentration among non–US citizens were significantly higher during the pandemic than prepandemic. Conclusions: Our results highlight the need for innovative strategies to sustain MPH degree interest and a diverse applicant pool.
The association between ultrasonographic findings and pain, physical function, and symptoms in patients with shoulder pain
Authors: Engin Onur , Çilengir Atilla Hikmet , Dirim Mete Berna 
Published: October 2024

Background Shoulder ultrasonography (US) is commonly employed to differentiate the causes of shoulder pain. However, the correlation between ultrasonographic findings and the individual's functional disability and daily activities remains unexplored. Purpose To investigate the relationship between shoulder US findings and physical function, disability, and pain. Material and Methods The study investigated patients with shoulder pain. Tendons of supraspinatus, infraspinatus, subscapularis, and long head of biceps brachii, acromiohumeral distance, and acromioclavicular joint (ACJ) degeneration were evaluated using US. The QuickDASH questionnaire was employed to evaluate physical function, symptoms, and disability, while the visual analog scale (VAS) was utilized to assess pain levels. Results The study included 84 patients (69 [82.1%] women, mean age = 55.7 ± 11.9 years). Ultrasonographic examination revealed ACJ degeneration in 61 (21.4%) patients and biceps tendinitis in 21 (25%) patients. In addition, supraspinatus tendinosis was identified in 51 (61%) patients, while 28 (33%) exhibited a supraspinatus tear. The patients demonstrated a mean VAS score of 7.03 ± 1.49 and mean QuickDASH score of 45.6 ± 15.3. Individuals with a supraspinatus tear exhibited higher VAS ( P = 0.008) and QuickDASH ( P = 0.016) scores. Patients presenting with ACJ degeneration demonstrated increased VAS scores ( P = 0.014), whereas those with biceps tendinopathy showed higher QuickDASH scores ( P = 0.035). Conclusion The results obtained from our research demonstrate significant correlations between ultrasonographic data and pain, disability, and physical manifestations. The findings of this study indicate that shoulder US provides valuable information regarding the difficulties individuals face in their daily tasks and the degree of pain they endure.
Correlation between sphenoid sinus pneumatization and sella turcica dimensions using computed tomography
Authors: Hassan Nuhad A. , Ah Mahdi Mais , Irhyyim Noor S 
Published: October 2024

Objective This study was performed to determine the dimensions of the sella turcica (ST) in relation to sex, age groups, and sphenoid sinus (SS) pneumatization patterns in a cohort of Iraqi individuals. Methods This cross-sectional study analyzed computed tomography images of 99 individuals (53 men, 46 women) aged 24 to 59 years to measure ST dimensions, including length, width, height, depth, and surface area. SS pneumatization was classified by sex and age. We also examined the relationship between ST size and SS pneumatization patterns. Results Women exhibited a significantly greater mean ST depth (9.37 mm) than men (8.19 mm). The ST diameter was significantly larger in the middle-aged group (13.1 mm) than in the young adult group (11.83 mm). The ST area showed a highly significant difference between sexes. The sellar pneumatization pattern was the most common, whereas the conchal pattern had the lowest prevalence. A significant correlation was observed between ST size and SS pneumatization. Conclusion The ST depth and diameter showed statistically significant differences across sex and age groups, respectively. The variability in SS pneumatization patterns underscores the importance of considering pneumatization types during surgical planning to minimize the risk of iatrogenic injury and improve treatment outcomes.
Effects of Income Distribution and Fiscal Policy on Growth in Turkey: A Kaleckian Analysis
Authors: Yilmaz Eda , Bahçe Serdal 
Published: October 2024

This study examines the effects of functional income distribution and fiscal policy on growth in Turkey. A post-Kaleckian open economy model is used to analyze the Turkish economy by integrating fiscal policy tools into the econometric model, such as tax burdens on labor and capital and government expenditure for 1988–2017. The novelty of our study is that it considers the private profit motive and rollback of government activities by including public-private partnership investments in the model. Our findings suggest that government ideologies in providing services through different channels do not cause alteration in the domestic demand regime; it stays wage-led in all scenarios we applied. Yet, the overall regime turns out to be profit-led since net export is sensitive to labor costs. JEL Classification: E12, E62, L33