bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and characterization of 2‐hydroxyethylmethacrylate/2‐(3‐indol‐yl)ethylmethacrylamide‐based novel hydrogels as drug carrier with in vitro antibacterial properties
Authors: Ilgin Pinar , Selcuk Zorer Ozlem , Ozay Ozgur , Boran Gokhan 
Published: August 2017

ABSTRACTIn this study, a new cationic monomer 2‐(3‐indol‐yl)ethylmethacrylamide (IEMA) derived from tryptamine was synthesized in a single step and characterized by Fourier transform infrared (FTIR), 1H‐NMR, and 13C‐NMR. Then, one‐step preparation of novel poly[2‐hydroxyethylmethacrylate‐c‐2‐(3‐indol‐yl)ethylmethacrylamide], or p(HEMA‐c‐IEMA), copolymeric hydrogels has been performed successfully with IEMA and 2‐hydroxyethylmethacrylate (HEMA) as monomers using free radical aqueous polymerization. The hydrogels were characterized with scanning electron microscopy, FTIR, elemental analysis, thermogravimetric analysis, and texture profile analysis instruments. p(HEMA‐c‐IEMA) hydrogels were used for swelling, diffusion, drug release, and antibacterial activity studies. The drug‐release behavior of the hydrogels was determined as a function of time at 37 °C in pH 1.2 and 7.2. The swelling and drug‐release studies showed that an increased IEMA amount caused a higher increase in swelling and drug‐release values. Additionally, zero‐order, first‐order, and Higuchi equation kinetic models were applied to the drug‐release data, and the data fit well in the Higuchi model, and the Peppas power‐law model was applied to the release mechanism. Finally, the antibacterial activities of the hydrogels were screened against Gram‐positive bacteria (Bacillus cereus and Staphylococcus aureus) and Gram‐negative bacteria (Escherichia coli and Salmonella typhimurium). © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45550.
Development of an electrochemical‐surface plasmon dual biosensor based on carboxylated conducting polymer thin films
Authors: Sriwichai Saengrawee , Janmanee Rapiphun , Phanichphant Sukon , Shinbo Kazunari , Kato Keizo , Kaneko Futao , Yamamoto Tadashi , Baba Akira 
Published: August 2017

ABSTRACTA biosensing platform based on the covalent attachment of biomolecules on electropolymerized carboxylated conducting polymers, poly(3‐aminobenzoic acid) and poly(3‐pyrrole carboxylic acid), were developed for the selective simultaneous detection of two biomolecules using electrochemical‐surface plasmon resonance (EC–SPR) spectroscopy. The surface morphology of the developed biosensors was studied by scanning electron microscopy and atomic force microscopy. The EC–SPR dual biosensor was developed for the label‐free, simultaneous, and selective detection of glucose and human immunoglobulin G (IgG). A change in current density was clearly observed after the injection of glucose, whereas a change in SPR reflectivity was clearly observed after the injection of human IgG. The present work demonstrates the potential of this biosensing platform for real sample analysis in the future. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45641.
Flexible Bayesian additive joint models with an application to type 1 diabetes research
Authors: Köhler Meike , Umlauf Nikolaus , Beyerlein Andreas , Winkler Christiane , Ziegler Anette‐Gabriele , Greven Sonja 
Published: August 2017

AbstractThe joint modeling of longitudinal and time‐to‐event data is an important tool of growing popularity to gain insights into the association between a biomarker and an event process. We develop a general framework of flexible additive joint models that allows the specification of a variety of effects, such as smooth nonlinear, time‐varying and random effects, in the longitudinal and survival parts of the models. Our extensions are motivated by the investigation of the relationship between fluctuating disease‐specific markers, in this case autoantibodies, and the progression to the autoimmune disease type 1 diabetes. Using Bayesian P‐splines, we are in particular able to capture highly nonlinear subject‐specific marker trajectories as well as a time‐varying association between the marker and event process allowing new insights into disease progression. The model is estimated within a Bayesian framework and implemented in the R‐packagebamlss.
Full mouth rehabilitation with retrievable metal–ceramic implant‐supported fixed prostheses for a young patient with atrophic jaws: a clinical report
Authors: Ameri Narges , Alikhasi Marzieh , Rezayani Vida 
Published: August 2017

Key Clinical MessageTreatment of atrophic edentulous jaws with implant‐supported fixed prostheses is one of the most complicated challenges in dentistry. This clinical report describes the prosthesis which consists of screw retained frameworks with individual cement retained crowns which combines the advantages of the screw retained restoration with the advantage of cement retained.
High Performance and Active Sites of a Ceria‐Supported Palladium Catalyst for Solvent‐Free Chemoselective Hydrogenation of Nitroarenes
Authors: Shi Xiuxiu , Wang Xueguang , Shang Xingfu , Zou Xiujing , Ding Weizhong , Lu Xionggang 
Published: August 2017

AbstractCerium oxide‐supported palladium catalysts (Pd/CeO2) prepared by a simple impregnation method exhibit exciting catalytic activity and high chemoselectivity for the solvent‐free hydrogenation of a variety of substituted nitroarenes including the reducible functional groups to the corresponding aromatic amines under mild reaction conditions. Taking nitrobenzene as an example, the Pd/CeO2 catalyst can afford aniline yields of >99 % with turnover frequencies as high as 11 411 h−1 and 69 824 h−1 at 40 °C and 100 °C, respectively. Pd2+ ion species exist as isolated single atoms with −Pd2+−O2−−Ce4+− linkages on the surface of PdxCe1−xO2−σ solid solution and are found to be active sites for the selective hydrogenation of nitroarenes in the absence of solvent. The superior catalytic performance can be attributed to the cooperative effect between Pd2+ ions and unique surface sites of CeO2. A possible mechanism is proposed for the hydrogenation of nitroarenes with H2 over the Pd/CeO2. The Pd/CeO2 catalyst can be recovered easily and reused for at least seven recycling reactions without loss of catalytic properties.
Present‐day and future contribution of climate and fires to vegetation composition in the boreal forest of China
Authors: Wu Chao , Venevsky Sergey , Sitch Stephen , Yang Yang , Wang Menghui , Wang Lei , Gao Yu 
Published: August 2017

AbstractClimate is well known as an important determinant of biogeography. Although climate is directly important for vegetation composition in the boreal forests, these ecosystems are strongly sensitive to an indirect effect of climate via fire disturbance. However, the driving balance of fire disturbance and climate on composition is poorly understood. In this study, we quantitatively analyzed their individual contributions for the boreal forests of the Heilongjiang Province, China, and their response to climate change using four warming scenarios (+1.5°, 2°, 3°, and 4°C). This study employs the statistical methods of Redundancy Analysis (RDA) and variation partitioning combined with simulation results from a SErgey VERsion Dynamic Global Vegetation Model (SEVER‐DGVM), and remote sensing datasets of global land cover (GLC2000) and the third version of Global Fire Emissions Database (GFED3). Results show that the vegetation distribution for the present day is mainly determined directly by climate (35%) rather than fire (1–10.9%). However, with a future global warming of 1.5°C, local vegetation composition will be determined by fires rather than climate (36.3% > 29.3%). Above 1.5°C warming, temperature will be more important than fires in regulating vegetation distribution although other factors such as precipitation can also contribute. The spatial pattern in vegetation composition over the region, as evaluated by Moran's Eigenvector Map (MEM), has a significant impact on local vegetation coverage; for example, composition at any individual location is highly related to that in its neighborhood. It represents the largest contribution to vegetation distribution in all scenarios, but will not change the driving balance between climate and fires. Our results are highly relevant for forest and wildfires' management.
Empirical evaluation of peak ground velocity and displacement as a function of elastic spectral ordinates for design
Authors: Paolucci Roberto , Smerzini Chiara 
Published: August 2017

SummaryIn the framework of the revision of Part 1 of Eurocode 8, this study aims at developing new empirical correlations to compute peak values of ground velocity (PGV) and displacement (PGD) as a function of elastic spectral ordinates for design. At variance with the expressions for PGV and PGD currently adopted in the Eurocode 8, based solely on the peak ground acceleration (PGA), in this paper reference is made to spectral ordinates of the short and intermediate period range, namely Ss, which is the constant acceleration spectral ordinate, and S1, which is the spectral ordinate at 1 s. On the one hand, a relationship between PGV and the product (Ss⋅S1) was found based on the regression analysis on a high‐quality strong‐motion dataset. On the other hand, the PGD was estimated by extrapolating to long periods the constant displacement branch of the elastic response spectrum, introducing a correlation between the corner period TD and S1. For this purpose, results of a long period probabilistic seismic hazard assessment study for Italy, encompassing low to high seismicity areas, were considered. Furthermore, verification of the proposed relationship against strong‐motion records was carried out, and differences justified in terms of the concept of uniform hazard spectrum.
G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia
Authors: Jolly Sarah , Bazargani Narges , Quiroga Alejandra C. , Pringle Nigel P. , Attwell David , Richardson William D. , Li Huiliang 
Published: August 2017

AbstractWe show that the G protein‐coupled receptor GPR37‐like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes. Comparison of wild type and Gpr37l1–/– mice showed that loss of GPR37L1 did not affect the input resistance or resting potential of astrocytes or neurons in the hippocampus. However, GPR37L1‐mediated signalling inhibited astrocyte glutamate transporters and – surprisingly, given its lack of expression in neurons – reduced neuronal NMDA receptor (NMDAR) activity during prolonged activation of the receptors as occurs in ischemia. This effect on NMDAR signalling was not mediated by a change in the release of D‐serine or TNF‐α, two astrocyte‐derived agents known to modulate NMDAR function. After middle cerebral artery occlusion, Gpr37l1 expression was increased around the lesion. Neuronal death was increased by ∼40% in Gpr37l1–/– brain compared to wild type in an in vitro model of ischemia. Thus, GPR37L1 protects neurons during ischemia, presumably by modulating extracellular glutamate concentration and NMDAR activation.
Measurement tools of resource use and quality of life in clinical trials for dementia or cognitive impairment interventions: A systematically conducted narrative review
Authors: Yang Fan , Dawes Piers , Leroi Iracema , Gannon Brenda 
Published: August 2017

ObjectiveKnowledge is limited about the standardised instruments used to collect resource use and quality of life data alongside trials of dementia interventions. This review aimed to identify the trials using such instruments in order to guide the design of future trial‐based cost‐effectiveness studies.MethodsIn accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Statement, this review examined all original, peer‐reviewed research in major databases and general searches published until June 2017, including randomised clinical trials, pilot studies, or feasibility studies about interventions for older adults with dementia or cognitive impairment.ResultsForty‐one studies were identified. Only 8 collected the resource use data using adapted Client Service Receipt Inventory (CSRI), Resource Use Inventory (RUI), cost diary, or study‐specific questionnaire. Quality of life was assessed using a wide range of instruments. The most frequently used dementia‐specific instrument was Quality of Life in Alzheimer's Disease (QOL‐AD) and Dementia Quality of Life questionnaire (DEMQOL). Among the generic measures, EuroQol 5‐dimentison (EQ‐5D) was mostly used to collect health utility data, and Short Form surveys (SF‐36 or SF‐12) were widely to measure general health.ConclusionsSeveral useful resource use and quality of life measurement instruments have been identified by this review. For resource use, CSRI was mostly used, but no studies have used Resource Utilisation in Dementia (RUD); for quality of life, we recommend the inclusion of dementia‐specific DEMQOL, generic SF‐12, and health utility EQ‐5D‐5L, based on both self‐report and proxy‐report.
Core‐shell fibrous scaffold as a vehicle for sustained release of retinal pigmented epithelium‐derived factor (PEDF) for photoreceptor differentiation of conjunctiva mesenchymal stem cells
Authors: Nasehi Fatemeh , Karshenas Mohsen , Nadri Samad , Barati Ghasem , Salim Ahdiye 
Published: August 2017

AbstractCoaxial electrospinning technique was introduced as a flexible and promising technique for the fabrication of core‐shell fibrous scaffold from poly ethylene glycol/poly caprolactone (PEG/PCL), where retinal pigmented epithelium‐derived factor (PEDF) was encapsulated in the core, for photoreceptor differentiation of conjunctiva mesenchymal stem cells (CJMSCs) seed on scaffolds. The morphology and structure of fibers were characterized using SEM and TEM and photoreceptor differentiation was examined by quantitative real time PCR (qPCR). Release study showed that, a sustained release of PEDF from PEG/PCL scaffold was observed over 14 days. qPCR analysis demonstrated that rhodopsin (as a main photoreceptor gene) was significantly expressed in CJMSCs cultured on scaffold loaded with PEDF. According to the result, the core‐shell scaffold loaded with PEDF (PEG + PEDF)/PCL) has superior control over factor release profile and has a potential for guiding photoreceptor differentiation of mesenchymal stem cells and promoting retinal regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3514–3519, 2017.
Decadal prediction skill of BCC‐CSM1.1 climate model in East Asia
Authors: Xin Xiaoge , Gao Feng , Wei Min , Wu Tongwen , Fang Yongjie , Zhang Jie 
Published: August 2017

ABSTRACTThe forecast skill of BCC‐CSM1.1 model in summer East Asian climate was evaluated with the decadal prediction experiments launched annually during 1961–2005. Results of the decadal prediction were compared with those of the historical simulation to estimate contribution of the initialization. Improved prediction skill is found for summer surface air temperature (SAT) in central eastern China measured by both root mean square error (RMSE) and anomaly correlation coefficient (ACC) for the forecast years 2–5. The decadal hindcast of precipitation in central eastern China shows increased skill in RMSE but not ACC. Such improvement in East Asia is related to enhanced prediction skill of the western Pacific (WP) sea surface temperature (SST) originated from the oceanic initialization. In the decadal hindcast, the lower tropospheric atmospheric circulation associated with warm WP exhibits an anticyclone over the South China Sea, which resembles the observation. The southwesterly increases over southeast China associated with warm WP, favouring higher SAT in central eastern China. This reveals that the decadal predictions could more realistically reproduce the relationship between summer East Asian atmospheric circulation and WP SST. The 4‐year average forecast within a decade shows that the initialization increases the ACC skill up to forecast years 4–7 for summer SAT in central eastern China.
Surface wind speed: trend and climatology of Brazil from 1980–2014
Authors: Gilliland Joshua M. , Keim Barry D. 
Published: August 2017

ABSTRACTThis study examines the spatial and temporal surface (10 m) wind speed trend characteristics of Brazil during 1980–2014 using two in situ and three climate reanalysis datasets. Nonparametric regression is used to understand how mean seasonal and annual wind speeds change over space and time across Brazil. Overall temporal linear trends show that station and reanalysis products exhibit varying seasonal and annual wind speed trends. A geographic examination displays statistically significant (P < 0.05) positive (negative) mean wind speed trends for equatorial (southeastern and central) Brazil. Quantile regression is performed to interpret how wind speed changed across different percentiles. Results show that the largest positive and negative spatial wind speed trends occur for the upper percentiles (75 and 95%). The spatial and temporal trends and correlations described could be interconnected to possible changes developing with the location of Intertropical Convergence Zone and South Atlantic Anticyclone over the study region. Results have implications for optimizing renewable wind energy production and development across Brazil.
Magnetic porous carbon derived from Co‐doped metal–organic frameworks for the magnetic solid‐phase extraction of endocrine disrupting chemicals
Authors: Hao Lin , Wei Jiayi , Zheng Ruixue , Wang Chun , Wu Qiuhua , Wang Zhi 
Published: August 2017

AbstractMetal–organic frameworks‐5 (MOF‐5) was explored as a template to prepare porous carbon due to its high surface area, large pore volume, and permanent nanoscale porosity. Magnetic porous carbon, Co@MOF‐5‐C, was fabricated by the one‐step direct carbonization of Co‐doped MOF‐5. After carbonization, the magnetic cobalt nanoparticles are well dispersed in the porous carbon matrix, and Co@MOF‐5‐C displays strong magnetism (with the saturation magnetization intensity of 70.17emu/g), high‐specific surface area, and large pore volume. To evaluate its extraction performance, the Co@MOF‐5‐C was applied as an adsorbent for the magnetic solid‐phase extraction of endocrine disrupting chemicals, followed by their analysis with high‐performance liquid chromatography. The developed method exhibits a good linear response in the range of 0.5–100 ng/mL for pond water and 1.0–100 ng/mL for juice samples. The limits of detection (S/N = 3) for the analytes were in the range of 0.1–0.2 ng/mL.
Lowering the Healing Temperature of Photoswitchable Dynamic Covalent Polymer Networks
Authors: Fuhrmann Anne , Broi Kevin , Hecht Stefan 
Published: August 2017

AbstractTo reduce the environmental footprint of the modern society, it is desirable to elongate the lifetime of consumer products, for example by implementing healable coatings and protective layers. However, since most healing processes carried out by heat or light suffer from material degradation, improving the robustness and integrity of healable materials is of tremendous importance to prolong their lifetime. In recent work, a prototype is created of a dynamic covalent polymer network, whose thermal healing ability can be switched “on” and “off” by light to provide a means to locally control repair of a damaged coating. Based on the initial concept, herein a new set of difunctional crosslinkers and linear polymers of various compositions is presented to form dynamic covalent polymer networks, in which the barrier for the retro Diels–Alder decrosslinking reaction is decreased. The approach results in lower healing temperatures and thus a longer lifetime of the material.
Technical Note: The effect of 2D excitation profile on T1 measurement accuracy using the variable flip angle method with an average flip angle assumption
Authors: Svedin Bryant T. , Parker Dennis L. 
Published: August 2017

PurposeTo study the accuracy and precision of T1 estimates using the Variable Flip Angle (VFA) method in 2D and 3D acquisitions.MethodsExcitation profiles were simulated using numerical implementation of the Bloch equations for Hamming‐windowed sinc excitation pulses with different time‐bandwidth products (TBP) of 2, 6, and 10 and for T1 values of 295 ms and 1045 ms. Experimental data were collected in 5° increments from 5° to 90° for the same T1 and TBP values. T1 was calculated for every combination of flip angle with and without a correction for B1 and slice profile variation. Calculations were also made for flat slice profile such as obtained in 3D acquisition. Monte Carlo simulations were performed to obtain T1 measurement uncertainty.ResultsVFA T1 measurements in 2D without correction can result in a 40–80% underestimation of true T1. Flip angle correction can reduce the underestimation, but results in accurate measurements of T1 only within a narrow band of flip angle combinations. The narrow band of accuracy increases with TBP, but remains too narrow for any practical range of T1 values or B1 variation. Simulated noisy VFA T1 measurements in 3D were accurate as long as the two angles chosen are on either side of the Ernst angle.ConclusionsAccurate T1 estimates from VFA 2D acquisitions are possible, but only a narrow range of T1 values within a narrow range of flip angle combinations can be accurately calculated using a 2D slice. Unless a better flip angle correction method is used, these results demonstrate that accurate measurements of T1 in 2D cannot be obtained robustly enough for practical use and are more likely obtained by a thin slab 3D VFA acquisition than from multiple‐slice 2D acquisitions. VFA T1 measurements in 3D are accurate for wide ranges of flip angle combinations and T1 values.
Application of differentiated human tonsil–derived stem cells to trembler‐J mice
Authors: Park Saeyoung , Choi Yoonyoung , Kwak Geon , Hong Young Bin , Jung Namhee , Kim Jieun , Choi Byung‐ok , Jung Sung‐Chul 
Published: August 2017

ABSTRACTIntroductionMesenchymal stem cells (MSCs) can differentiate into various cell types.MethodsIn this study we investigated the potential of human tonsil–derived MSCs (T‐MSCs) for neuromuscular regeneration in trembler‐J (Tr‐J) mice, a model for Charcot–Marie–Tooth disease type 1A (CMT1A).ResultsT‐MSCs differentiated toward skeletal myocytes with increased expression of skeletal muscle–related markers (including troponin I type 1, and myogenin), and the formation of myotubes in vitro. In‐situ transplantation of T‐MSC–derived myocytes (T‐MSC myocytes) into the gastrocnemius muscle in Tr‐J mice enhanced motor function, with recovery of compound muscle action potential amplitudes. Morphology of the sciatic nerve and skeletal muscle recovered without the formation of teratomas, and the expression levels of nerve growth factor and glial‐cell‐line–derived neurotrophic factor were increased significantly in T‐MSC myocytes compared with T‐MSCs in vitro.DiscussionTransplantation of T‐MSC myocytes could enable neuromuscular regeneration in patients with CMT1A. Muscle Nerve 57: 478–486, 2018