bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular Wireframe DNA Polyhedra: Assembly and Applications
Authors: Li Yulin , Mao Chengde , Deng Zhaoxiang 
Published: May 2017

AbstractWireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three‐dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer great potentials in bottom‐up nanoengineering towards various applications. In this review, we summarize recent advances in the rational design and programmed assembly of DNA wireframe polyhedra. Their assembly is based on three distinctively different strategies: individual strands‐based assembly, tile‐based assembly, and scaffolded DNA origami. Applications of these polyhedral structures in templated nanomaterial assembly and in‐vivo cargo delivery are discussed. In the future, expanding the structural complexity and exploring their applications, especially in nanomaterials science and biomedicines, should be a primary focus of this rapidly developing and evolving activity of structural DNA nanotechnology.
A Fluorescent Zirconium‐Based Metal‐Organic Framework for Selective Detection of Nitro Explosives and Metal Ions
Authors: Tang Yuanzhe , Huang Hongliang , Peng Yaguang , Ruan Qunqun , Wang Keke , Yi Pengda , Liu Dahuan , Zhong Chongli 
Published: May 2017

AbstractIn this work, a new porous Zr‐based metal‐organic framework (MOF) with a large Brunner‐Emmet‐Teller (BET) surface area was prepared by the solvothermal method using 4,4’‐(naphthalene‐1,4‐diyl)dibenzoic acid (NDDA) as the organic ligand, and the luminescent detection performance was studied systematically. The experiments combing with computations indicate that the as‐synthesized material can sensitively and selectively detect nitro explosives and metal ions, especially for 2,4,6‐trinitrophenol (TNP) and Fe3+, due to the possible electron transfer from inorganic moieties to organic moieties with naphthalene part. Interestingly, owing to its high porosity and large surface area, this Zr‐MOF showed quick luminescent response time (in 1 min) for TNP and Fe3+. The results obtained may provide useful information for the design of MOFs with the large permanent porosity in sensing applications for large molecules in the future.
PADP: A parallel data possession audit model for cloud storage
Authors: Yang Lei , Xu Kui , Liu Shi 
Published: May 2017

SummaryData integrity is one of the most important attributes need to be concerned by the customers of cloud storage. We propose a parallel audit model for data possession in distributed cloud storage environment. The model utilizes the virtues of both a provable data possession model and a data possession audit model and adopts a third‐party auditor to separate users from storage service providers. By introducing the audit log mechanism, it can significantly reduce the storage and computation overhead of data possession audit while guarantee the safety of audit process. Moreover, according to the characteristics of parallel computing in cloud storage environment, we propose a data possession proving algorithm called MapReduce‐based Parallel Challenge Proof Generation Algorithm (MR_PCPGA) by improving the data possession prove algorithm based on homomorphic tag in provable data possession model. Extensive security analysis and experimental results show that the proposed schemes are provably secure and highly efficient in distributed cloud storage environment. Copyright © 2017 John Wiley & Sons, Ltd.
Favored Conformations of Carbonyl Compounds: A Structural Study of n‐Octanal
Authors: Truong Khai‐Nghi , Weger Lindsey B. , Stahl Wolfgang , Mouhib Halima 
Published: May 2017

AbstractWe report on the molecular structures of the two most abundant conformers of n‐octanal observed by molecular beam Fourier transform microwave spectroscopy. Next to limonene, which is the main component of citrus‐oil, octanal and other n‐alkyl aldehydes strongly enhance the typical fresh smell of lemon‐oil. Due to the high flexibility of its n‐alkyl chain and the high number of possible conformers, different semi‐empirical methods (AM1, PM3, MMFF94) were used to sample the conformational space of octanal before performing more sophisticated quantum chemical calculations at the MP2 level of theory. This technique has previously been shown to be an ideal tool to characterize relevant odorant structures in fragrance chemistry. The structure of octanal and structurally related molecules is discussed in the context of the most abundant chain conformations and the potential use of the microwave validated structures for further studies in biological media.
Freestanding Gold/Graphene‐Oxide/Manganese Oxide Microsupercapacitor Displaying High Areal Energy Density
Authors: Morag Ahiud , Becker James Y. , Jelinek Raz 
Published: May 2017

AbstractMicrosupercapacitors are touted as one of the promising “next frontiers” in energy‐storage research and applications. Despite their potential, significant challenges still exist in terms of physical properties and electrochemical performance, particularly attaining high energy density, stability, ease of synthesis, and feasibility of large‐scale production. We present new freestanding microporous electrodes comprising self‐assembled scaffold of gold and reduced graphene oxide (rGO) nanowires coated with MnO2. The electrodes exhibited excellent electrochemical characteristics, particularly superior high areal capacitance. Moreover, the freestanding Au/rGO scaffold also served as the current collector, obviating the need for an additional electrode support required in most reported supercapacitors, thus enabling low volume and weight devices with a high overall device specific energy. Stacked symmetrical solid‐state supercapacitors were fabricated using the Au/rGO/MnO2 electrodes in parallel configurations showing the advantage of using freestanding electrodes in the fabrication of low‐volume devices.
Unusual presentation of disseminated histoplasmosis in an immunocompetent patient
Authors: Kumari Manju , Udayakumar Madhumitha , Kaushal Manju , Madaan Garima Baweja 
Published: May 2017

AbstractDisseminated histoplasmosis (DH) is a systemic granulomatous disease caused by the fungus Histoplasma capsulatum. This disease occurs mainly in immunocompromised individuals with CD 4 counts less than 200 cell/µL and is rarely noted in immunocompetent person. In India, this disease has been reported from several parts of the country of which most cases are from eastern India which is considered to be endemic for this disease. Inhalation of the spores can lead to a self‐limiting flulike illness in immunocompetent hosts. The most common organs involved are liver, spleen, bone marrow, lymphoreticular system, and gastrointestinal tract. Cutaneous manifestations of histoplasmosis are rare and are seen predominantly in persons with advanced human immunodeficiency virus (HIV) infections. We present a case of DH with generalized cutaneous lesions in a non‐HIV infected adult which posed a diagnostic challenge to our clinical colleagues.
Developmental programming of happiness
Authors: Schmidt Louis A. , Fortier Paz , Lahat Ayelet , Tang Alva , Mathewson Karen J. , Saigal Saroj , Boyle Michael H. , Van Lieshout Ryan J. 
Published: May 2017

AbstractBeing born at an extremely low birth weight (ELBW; <1,000 grams) is presumed to reflect a suboptimal intrauterine environment and thus presents an opportunity for examining developmental programming hypotheses. Interfacing prenatal programming and differential susceptibility hypotheses, we tested whether individuals with ELBW in different childhood rearing environments showed different attention biases to positive and negative facial emotions in adulthood. Using the oldest known, prospectively followed cohort of ELBW survivors, we found that relative to normal birth weight controls (NBW; >2,500 grams), ELBW survivors displayed the highest and lowest attention bias to happy faces at age 30–35, depending on whether their total family income at age 8 was relatively low (environmental match) or high (environmental mismatch), respectively. This bias to happy faces was associated with a reduced likelihood of emotional problems. Findings suggest that differential susceptibility to positive emotions may be prenatally programmed, with effects lasting into adulthood. We discuss implications for integrating prenatal programming and differential susceptibility hypotheses, and the developmental origins of postnatal plasticity and resilience.
Reconsidering EU Compliance: Implementation performance in the field of environmental policy
Authors: Bondarouk Elena , Mastenbroek Ellen 
Published: May 2017

AbstractEuropean Union (EU) environmental policy can only work in practice when it is implemented by and within the member states. Yet, despite its importance, we still lack a solid and cumulative understanding of the practical implementation of EU environmental policies, mainly because of the dominance of case‐specific empirical insights and the dichotomous conceptualization of compliant implementation. This paper proposes a conceptual framework for analysing implementation performance, which is built around three dimensions: substance, scope and effort. The framework's relevance and analytical quality are substantiated by a systematic review of empirical studies on practical implementation of 18 EU environmental directives. We find evidence of three types of knowledge deficits: there is neglect of the ‘scope’ and ‘effort’ dimensions of implementation; disproportionate attention to the Water Framework Directive, and the Northern and Western European member states. The proposed conceptual framework aims to inform future research on EU environmental implementation. © 2017 The Authors. Environmental Policy and Governance published by ERP Environment and John Wiley & Sons Ltd
Long‐term efficacy and safety of oxycodone‐naloxone prolonged‐release formulation (up to 180/90 mg daily) – results of the open‐label extension phase of a phase III multicenter, multiple‐dose, randomized, controlled study
Authors: Dupoiron D. , Stachowiak A. , Loewenstein O. , Ellery A. , Kremers W. , Bosse B. , Hopp M. 
Published: May 2017

AbstractBackgroundThe inclusion of naloxone with oxycodone in a fixed combination prolonged‐release formulation (OXN PR) improves bowel function compared with oxycodone (Oxy) alone without compromising analgesic efficacy. In a recent 5‐week, randomized, double‐blind comparative trial of OXN PR and OxyPR, it could be shown that the beneficial properties of OXN PR extend to doses up to 160/80 mg.MethodsBowel function, pain, quality of life (QoL) and safety of OXN PR up to 180/90 mg daily were evaluated in a 24‐week open‐label extension phase of the 5‐week randomized comparative study in patients with non‐malignant or malignant pain requiring opioids and suffering from opioid‐induced constipation.ResultsDuring treatment with a mean (SD) daily dose OXN PR of 130.7 (26.56) mg (median, maximum: 120 and 180 mg), the Bowel Function Index (BFI) decreased from 45.3 (26.37) to 26.7 (21.37) with the largest decrease seen in the first week. The average pain over the last 24 h remained stable (median Pain Intensity Scale score 4.0) and QoL was maintained throughout the study. Adverse events were consistent with the known effects of OXN PR and no new safety concerns emerged. Equivalent efficacy and safety benefits were observed in cancer patients.ConclusionsThe OXN PR in doses up to 180/90 mg provides effective analgesia with maintenance of bowel function during long‐term treatment. The beneficial effects of such dose levels of OXN PR contribute to stable patient‐reported QoL and health status despite serious underlying pain conditions, such as cancer.SignificanceIn patients with pain requiring continuous opioid therapy at doses above 80 mg of oxycodone, stable and effective long‐term analgesia can be achieved using OXN PR up to 180/90 mg daily without compromising bowel function and may be preferential to supplemental oxycodone.
Children with chronic stress‐induced recurrent muscle pain have enhanced startle reaction
Authors: Alfvén G. , Grillner S. , Andersson E. 
Published: May 2017

AbstractBackgroundChildren with recurrent pain of negative chronic stress origin from different locations have a characteristic pattern of tender points in the temporal, trapezoid, great pectoral and abdominal muscles. We tested the hypothesis that the startle reaction is activated in these children and that some of the startle‐activated muscles are related to the tender point pattern and the recurrent pain.MethodsIn children/adolescents, aged 10–17 years, 19 with recurrent psychosomatic pain (PAIN) and 23 controls (CON) we measured and analysed resting activity and acoustic startle response with electromyography (EMG) for the muscles involved in the pattern of tender points and also the lumbar erector spinae.ResultsThe PAIN group showed higher resting activity and higher acoustic startle response values than the CON group for all six muscles together regarding the mean amplitude in the initial 200 ms, and during the burst of activity, and longer burst duration and shorter burst latency. For PAIN versus CON, all separate muscles showed generally higher values of EMG amplitudes and burst durations, and shorter latencies for the burst onset in all measures; with significance or strong trends for several parameters and muscles.ConclusionFor the first time in children with recurrent psychosomatic pain, increased resting activity and potentiated startle response were demonstrated in the muscles involved in the stress tender point pattern.SignificanceThis study demonstrates in adolescents how recurrent pain of negative stress origin from the head, stomach, back and chest is related to increased startle reaction and increased muscular tension in these regions. This study contributes to the understanding of the mechanisms underlying the global burden of recurrent pain.
Short‐Term Treatment Outcomes and Dropout Risk in Men and Women with Eating Disorders
Authors: Agüera Zaida , Sánchez Isabel , Granero Roser , Riesco Nadine , Steward Trevor , Martín‐Romera Virginia , Jiménez‐Murcia Susana , Romero Xandra , Caroleo Mariarita , Segura‐García Cristina , Menchon José Manuel , Fernández‐Aranda Fernando 
Published: May 2017

AbstractThis study compared treatment outcomes between men and women with eating disorders (EDs) and analysed clinical predictors of treatment outcome. Our sample consisted of 131 male and 131 female ED patients who underwent cognitive behavioural therapy treatment. ED severity, personality and psychopathology were assessed using standard instruments. We found that the risk of dropout was higher for men with bulimia nervosa (BN) than for women with BN and that men with BN and other specified feeding and EDs were more likely to obtain full remission in comparison with their female counterparts. Predictive models of treatment outcome indicated that higher scores in novelty seeking were a shared factor associated with higher risk of dropout and not obtaining full remission for both men and women with ED. However, only in men, younger age and lower scores in reward dependence predicted higher dropout. Contrastingly, higher persistence scores were predictors of full remission. This study reinforces the effectiveness of using outpatient cognitive behavioural therapy as treatment as usual for men with ED. Nonetheless, placing greater emphasis on strategies targeting gender‐specific issues could enhance outcomes. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Acute and chronic toxicity of aluminum to a unionid mussel (Lampsilis siliquoidea) and an amphipod (Hyalella azteca) in water-only exposures
Authors: Wang Ning , Ivey Chris D. , Brunson Eric L. , Cleveland Danielle , Ingersoll Chris G. , Stubblefield William A. , Cardwell Allison S. 
Published: May 2017

Abstract

The US Environmental Protection Agency (USEPA) is reviewing the protectiveness of the national ambient water quality criteria (WQC) for aluminum (Al) and compiling a toxicity data set to update the WQC. Freshwater mussels are one of the most imperiled groups of animals in the world, but little is known about their sensitivity to Al. The objective of the present study was to evaluate acute 96-h and chronic 28-d toxicity of Al to a unionid mussel (Lampsilis siliquoidea) and a commonly tested amphipod (Hyalella azteca) at a pH of 6 and water hardness of 100 mg/L as CaCO3. The acute 50% effect concentration (EC50) for survival of both species was &gt;6200 μg total Al/L. The EC50 was greater than all acute values in the USEPA acute Al data set for freshwater species at a pH range of 5.0 to &lt;6.5 and hardness normalized to 100 mg/L, indicating that the mussel and amphipod were insensitive to Al in acute exposures. The chronic 20% effect concentration (EC20) based on dry weight was 163 μg total Al/L for the mussel and 409 μg total Al/L for the amphipod. Addition of the EC20s to the USEPA chronic Al data set for pH 5.0 to &lt;6.5 would rank the mussel (L. siliquoidea) as the fourth most sensitive species and the amphipod (H. azteca) as the fifth most sensitive species, indicating the 2 species were sensitive to Al in chronic exposures. The USEPA-proposed acute and chronic WQC for Al would adequately protect the mussel and amphipod tested; however, inclusion of the chronic data from the present study and recalculation of the chronic criterion would likely lower the proposed chronic criterion. Environ Toxicol Chem 2018;37:61–69. Published 2017 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
Feasibility of a staff training and support programme to improve pain assessment and management in people with dementia living in care homes
Authors: Petyaeva Anya , Kajander Martine , Lawrence Vanessa , Clifton Lei , Thomas Alan J. , Ballard Clive , Leroi Iracema , Briggs Michelle , Closs Jose , Dening Tom , Nunez Kayleigh‐Marie , Testad Ingelin , Romeo Renee , Johar Iskandar , Corbett Anne 
Published: May 2017

ObjectivesThe objective of this study was to establish the feasibility and initial effectiveness of training and support intervention for care staff to improve pain management in people with dementia living in care homes (PAIN‐Dem).MethodsPAIN‐Dem training was delivered to care staff from three care homes in South London, followed by intervention support and resources to encourage improved pain management by staff over 4 weeks. Feasibility was assessed through fidelity to intervention materials and qualitative approaches. Focus group discussions with staff explored the use of the PAIN‐Dem intervention, and interviews were held with six residents and family carers. Pain was assessed in all residents at baseline, 3 and 4 weeks, and goal attainment scaling was assessed at 4 weeks.ResultsDelivery of training was a key driver for success and feasibility of the PAIN‐Dem intervention. Improvements in pain management behaviour and staff confidence were seen in homes where training was delivered in a care home setting across the care team with good manager buy‐in. Family involvement in pain management was highlighted as an area for improvement. Goal attainment in residents was significantly improved across the cohort, although no significant change in pain was seen.ConclusionsThis study shows good initial feasibility of the PAIN‐Dem intervention and provides valuable insight into training and support paradigms that deliver successful learning and behaviour change. There is a need for a larger trial of PAIN‐Dem to establish its impact on resident pain and quantifiable staff behaviour measures. Copyright © 2017 John Wiley & Sons, Ltd.
Modulation of 7 T fMRI Signal in the Cerebellar Cortex and Nuclei During Acquisition, Extinction, and Reacquisition of Conditioned Eyeblink Responses
Authors: Ernst Thomas M. , Thürling Markus , Müller Sarah , Kahl Fabian , Maderwald Stefan , Schlamann Marc , Boele Henk‐Jan , Koekkoek Sebastiaan K. E. , Diedrichsen Jörn , De Zeeuw Chris I. , Ladd Mark E. , Timmann Dagmar 
Published: May 2017

AbstractClassical delay eyeblink conditioning is likely the most commonly used paradigm to study cerebellar learning. As yet, few studies have focused on extinction and savings of conditioned eyeblink responses (CRs). Saving effects, which are reflected in a reacquisition after extinction that is faster than the initial acquisition, suggest that learned associations are at least partly preserved during extinction. In this study, we tested the hypothesis that acquisition‐related plasticity is nihilated during extinction in the cerebellar cortex, but retained in the cerebellar nuclei, allowing for faster reacquisition. Changes of 7 T functional magnetic resonance imaging (fMRI) signals were investigated in the cerebellar cortex and nuclei of young and healthy human subjects. Main effects of acquisition, extinction, and reacquisition against rest were calculated in conditioned stimulus‐only trials. First‐level β values were determined for a spherical region of interest (ROI) around the acquisition peak voxel in lobule VI, and dentate and interposed nuclei ipsilateral to the unconditioned stimulus. In the cerebellar cortex and nuclei, fMRI signals were significantly lower in extinction compared to acquisition and reacquisition, but not significantly different between acquisition and reacquisition. These findings are consistent with the theory of bidirectional learning in both the cerebellar cortex and nuclei. It cannot explain, however, why conditioned responses reappear almost immediately in reacquisition following extinction. Although the present data do not exclude that part of the initial memory remains in the cerebellum in extinction, future studies should also explore changes in extracerebellar regions as a potential substrate of saving effects. Hum Brain Mapp 38:3957–3974, 2017. © 2017 Wiley Periodicals, Inc.
Low rates of contralateral neck failure in unilaterally treated oropharyngeal squamous cell carcinoma with prospectively defined criteria of lateralization
Authors: Hu Kenneth Shung , Mourad Waleed Fouad , Gamez Mauricio , Safdieh Joseph , Lin Wilson , Jacobson Adam Saul , Persky Mark Stephen , Urken Mark Lawrence , Culliney Bruce , Li Zujun , Tran Theresa Nguyen , Schantz Stimson Pryor , Chadha Juskaran , Harrison Louis Benjamin 
Published: May 2017

AbstractBackgroundUnilateral radiotherapy (RT) of oropharyngeal carcinomas is accepted for patients with lateralized primary and low‐volume nodal disease. Utilizing prospectively defined criteria of laterality and staging positron emission tomography (PET)/CT, we studied outcomes in patients with advanced‐stage oropharyngeal cancer undergoing unilateral RT.MethodsThirty‐seven patients with oropharyngeal tumors >1 cm from midline regardless of node status underwent unilateral RT and were followed prospectively. Patient characteristics: T1 = 11; T2 = 22; T3 = 4; N0 = 3; N1 = 9; N2a = 3; N2b = 21; and Nx = 1. Dosimetry were determined and weekly National Comprehensive Cancer Network (NCCN) distress thermometer data were collected.ResultsAt median follow‐up of 32 months, 3‐year locoregional control, contralateral regional failure, distant metastasis‐free survival, and disease‐free survival were 96%, 0%, 7%, and 93%, respectively.ConclusionLow rates of contralateral neck failure are demonstrated utilizing prospectively defined criteria for unilateral RT. The tolerances of contralateral organs are respected and patients report low to moderate levels of distress throughout treatment.