bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDI INTERAKSI KURKUMIN-ARTEMISIN DAN TURUNANNYA TERHADAP RESEPTOR SARCOENDOPLASMA RETICULUM Ca+2 SECARA IN SILICO
Authors: - Frengki , Saura Erda Rama , - Rinidar 
Published: April 2016

Penelitian ini bertujuan memodelkan interaksi molekuler enzim Sarcoendoplasmic Reticulum Ca+ (SERCA) oleh kurkumin-artemisin dan turunannya secara in silico. Penelitian ini menggunakan 10 senyawa obat yaitu kurkumin, analog 1, analog 2, analog 3, analog 4, artemisin, dihidroartemsin, artemeter, artesunat dan ATP. Senyawa penambatan yang digunakan adalah 2EAS yang didapat dari situs Protein Data Bank (PDB). Senyawa ujinya yaitu kurkumin, analog 1, analog 2, analog 3, analog 4, artemisin, dan turunannya. Semua ditambatkan menggunakan aplikasi ArgusLab 4.0.1. Proses penambatan dilakukan dengan metode ArgusDock. Hasil analisa menunjukkan semua senyawa uji mampu berikatan dengan reseptor SERCA. Berdasarkan penelitian ini disimpulkan bahwa kurkumin dan analognya mampu menghambat ikatan ATPreseptor secara kompetitif yang ditandai dengan energi Gibs (ΔG) yang lebih besar. Hal ini menunjukkan ikatan kurkumin dan analognya lebih stabil daripada ikatan ATP terhadap reseptornya, sedangkan artemisin dan turunannya mampu berikatan dengan SERCA pada site binding domain ion FePenelitian ini bertujuan memodelkan interaksi molekuler enzim Sarcoendoplasmic Reticulum Ca+ (SERCA) oleh kurkumin-artemisin dan turunannya secara in silico. Penelitian ini menggunakan 10 senyawa obat yaitu kurkumin, analog 1, analog 2, analog 3, analog 4, artemisin, dihidroartemsin, artemeter, artesunat dan ATP. Senyawa penambatan yang digunakan adalah 2EAS yang didapat dari situs Protein Data Bank (PDB). Senyawa ujinya yaitu kurkumin, analog 1, analog 2, analog 3, analog 4, artemisin, dan turunannya. Semua ditambatkan menggunakan aplikasi ArgusLab 4.0.1. Proses penambatan dilakukan dengan metode ArgusDock. Hasil analisa menunjukkan semua senyawa uji mampuberikatan dengan reseptor SERCA. Berdasarkan penelitian ini disimpulkan bahwa kurkumin dan analognya mampu menghambat ikatan ATPreseptor secarakompetitif yang ditandai dengan energi Gibs (ΔG) yang lebih besar. Hal ini menunjukkan ikatan kurkumin dan analognya lebih stabil daripada ikatan ATP terhadap reseptornya, sedangkan artemisin dan turunannya mampu berikatan dengan SERCA pada site binding domain ion Fe+2
DETEKSI AFLATOKSIN B1 PADA JENIS MAKANAN OLAHAN JAGUNG MENGGUNAKAN ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
Authors: - Safika , Jamin Faisal , Aisyah Siti 
Published: April 2016

Penelitian ini bertujuan mengetahui konsentrasi AFB1 pada jenis makanan olahan asal jagung yang dipasarkan di Banda Aceh. Pengambilan sampel dilakukan di pasar dan swalayan di Banda Aceh. Deteksi AFB1 pada sampel menggunakan metode enzyme-linked immunosorbent assay (ELISA). Berdasarkan penelitian, dapat disimpulkan bahwa dari 6 sampel makanan berbahan baku jagung, 5 sampel (83,33% ) terkontaminasi AFB1. Walaupun terkontaminasi AFB1 namun semua sampel masih aman dikonsumsi sesuai dengan persyaratan yang ditetapkan pemerintah yaitu maksimal 20 ppb.
EFEK PEMBERIAN MINYAK JELANTAH TERHADAP GAMBARANHISTOPATOLOGIS HATI TIKUS PUTIH (Rattus norvegicus)
Authors: Aisyah Siti , Budiman Hamdani , Florenstina BR. G Dessy , Aliza Dwinna , Salim M Nur , Balqis Ummu , Armansyah T. 
Published: April 2016

Penelitian ini bertujuan mempelajari gambaran histopatologi hati tikus putih (Rattus norvegicus) akibat mengonsumsi minyak jelantah. Duapuluh ekor tikus berumur 3 bulan dengan bobot badan ±250 g dibagi atas 4 kelompok perlakuan dan setiap kelompok terdiri at as 5 ekor. Perlakuan K1 (minyak goreng curah), K2, K3, dan K4 (minyak jelantah 3x, 6x, dan 9x pemakaian). Perlakuan dilakukan selama 60 hari, dan pada hari ke 61 dilakukan eutanasia yang dilanjutkan dengan nekropsi. Hati tikus diambil dan difiksasi dalam larutan buffered neutral formaline 10%untuk diproses sediaan histopatologis dan diwarnai dengan hematoksilin dan eosin (HE). Hasil penelitian menunjukkan bahwa hati berwarna coklat kehitaman, bengkak, dan ditemukan nodul multi fokal dengan konsistensi padat. Secara histopatologi terjadi peningkatan kongesti, degenerasi cloudy swelling, dan nekrosis sel
PENGARUH PEMBERIAN GETAH BUAH PEPAYA (Carica papaya L.) DAN POVIDONE IODINE TERHADAP KESEMBUHAN LUKA KASTRASI PADA KUCING (Felis domestica) JANTAN
Authors: - Amiruddin , - Syafruddin , - Zuraidawati , Desky Riani , Siregar Tongku Nizwan , Sayuti Arman , Harris Abdul 
Published: April 2016

Penelitian ini bertujuan mengetahui pengaruh pemberian getah buah pepaya (Carica papaya, L.) dan povidone iodine terhadap kesembuhan luka kastrasi pada kucing (Felis domestica) jantan. Penelitian ini menggunakan enam ekor kucing yang dibuat luka kastrasi, dibagi dalam dua kelompok perlakuan. Kelompok I (K1) dioleskan dengan getah buah pepaya dan Kelompok II (K2) dioleskan povidone iodine dua kali sehari selama tujuh hari berturut-turut. Parameter yang diamati adalah kesembuhan luka dengan memperhatikan tingkat kemerahan pada luka, kebengkakan, cairan radang, dan pertautan tepi luka. Pengamatan dilakukan setiap hari dan data hasil pengamatan dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa luka kastrasi pada K1 lebih cepat sembuh yaitu pada hari ke 4-5 dibandingkan K2 yaitu pada hari 6-7. Getah buah pepaya bisa dijadikan alternatif pengobatan tradisional dalam penyembuhan luka terutama luka sayat.
PENGARUH PENGGUNAAN GETAH BATANG PISANG KEPOK (Musaparadisiaca forma typica) TERHADAP PENYEMBUHAN LUKA OPERASI PADA ANJING LOKAL (Canis familiaris)
Authors: Daud Razali 
Published: April 2016

Penelitian ini bertujuan mengetahui potensi getah batang pisang kepok dalam proses penyembuhan luka operasi. Penelitian ini menggunakan 10 ekor anjing lokal (Canis familiaris) sehat yang berumur rata-rata 6 bulan dengan bobot badan 6-7 kg. Sebelum perlakuan dilaksanakan, semua anjing diadaptasikan selama tujuh hari di dalam kandang individu, setiap anjing dilakukan operasi laparotomi. Anjing dibagi dalam dua kelompok secara acak. Kelompok I diinjeksi penisilin-G dan dioleskan salep oksitetrasiklin pagi dan sore sebagai kontrol, kelompok II dioleskan getah batang pisang kepok pagi dan sore hari sebagai perlakuan. Pengamatan dilakukan setiap hari pada pagi hari sampai luka operasi sembuh. Data yang diperoleh dianalisis secara deskriptif berdasarkan pengamatan makroskopis terhadap luka kelompok I dan dibandingkan dengan kelompok II berdasarkan adanya kemerahan, kebengkakan, dan pertautan tepi luka. Pada kelompok II terjadi penyembuhan luka operasi yang sama dengan kelompok I. Dapat disimpulkan bahwa, penggunaan getah batang pisang kepok dapat menyembuhkan luka, sama halnya dengan proses kesembuhan luka yang menggunakan injeksi penisilin-G dan dioleskan salep oksitetrasiklin.
INFEKSI BAKTERI Escherichia coli PADA ANAK AYAM KAMPUNG (Gallus domesticus) DI PASAR LAMBARO ACEH BESAR
Authors: Jamin Faisal , Abrar Mahdi , Dewi Maryulia , S.V.S Yanrivina , - Fakhrurrazi , Manaf Zakiah Heryawaty , - Syafruddin 
Published: April 2016

Penelitian ini bertujuan mengetahui infeksi bakteri Escherichia coli pada anak ayam kampung (Gallus domesticus). Sampel yang digunakan dalam penelitian ini adalah feses anak ayam kampung yang diperoleh dari Pasar Lambaro, Aceh Besar. Sampel diambil dengan cara swab bagian kloaka anak ayam dengan menggunakan swab steril, kemudian sampel dimasukkan ke dalam microtube, dan dibawa ke laboratorium untuk dilakukan uji selanjutnya. Penelitian ini dilakukan dengan tiga kali pengambilan sampel dengan jangka waktu satu minggu dengan jumlah sampel uji sebanyak 15 sampel. Pengambilan sampel dilakukan dengan menggunakan metode Carter. Data yang diperoleh dianalisis secara deskriptif. Hasil pemeriksaan bakteri Escherichia coli (E. coli) yang telah dilakukan pada 15 sampel diketahui bahwa 9 sampel positif terinfeksi bakteri E. coli sedangkan 6 sampel lain positif bakteri coli form lainnya. Disimpulkan bahwa bakteri E. coli menginfeksi anak ayam kampung di Pasar Lambaro Aceh Besar.
PENGAMATAN BRUISES PADA MUSCULUS PECTORALIS AYAM BROILER YANG DIJUAL DI PASAR LAMBARO ACEH BESAR DAN HUBUNGANNYA DENGAN JUMLAH MIKROBA
Authors: Budiman Hamdani , Ferasyi T. Reza , Windasari Wulan , Salim M. Nur , Aisyah Siti , Hambal Muhammad 
Published: April 2016

Penelitian ini bertujuan mengetahui perbandingan jumlah mikroba antara ayam normal dengan ayam yang mengalami bruises. Sampel ayam broiler diperoleh di Pasar Lambaro Aceh Besar dengan memilih lima musculus pectoralis ayam normal dan lima musculus pectoralis ayam yang mengalami bruises untuk dilakukan uji mikrobiologis. Bagian musculus pectoralis ditimbang dengan berat 25 g, kemudian dilakukan stomaker untuk mendapatkan ekstrak. Selanjutnya dilakukan uji mikrobiologis, perhitungan jumlah koloni dilakukan selama 24 jam. Jumlah mikroba pada sampelayam normal masing-masing adalah Sn1 (1,6x102), Sn2 (2,6x103), Sn3 (3,5x102), Sn4 (1,3x103), dan Sn5 (1,2x102) Cfu/ml, sedangkan pada sampel ayam yang mengalami bruises masing-masing adalah Sb1 (3,8x104), Sb2 (3,0x104), Sb3 (1,3x105), Sb4 (1,9x105), dan Sb5 (1,6x105) Cfu/ml. Berdasarkan hasil penelitian dapat disimpulkan bahwa ayam yang mengalami bruises memiliki jumlah mikroba yang lebih tinggi dibandingkan dengan ayam normal.
Milky‐White Rice Prediction Based on Chalky Patterns on the Transverse Section of Premature Grains
Authors: Morita S. , Tanaka A. , Wada H. , Wakamatsu K. , Okano A. 
Published: April 2016

Climate change increases the occurrence of chalky rice (Oryza sativa L.) through frequent extreme weather conditions, such as high temperature and low radiation. The objective of this study was to examine the possibility of developing prediction methods for estimating the occurrence of a major type of chalky rice, the milky‐white rice. The methods evaluated the chalky patterns on the transverse section of premature grains by visual inspection or by employing a newly developed image analyzer. The predicted grain rates of milky‐white rice using the above‐mentioned method(s) as well as two other methods using a grain scanner, were compared with periodically sampled grains approaching maturity under shade treatments at Kagoshima and Fukuoka, Japan. The grain rates predicted using visual inspection and the developed analyzer at 6 to 7 d before maturity (DBM) and 9 to 10 DBM, were positively correlated with the target grain rates of milky‐white rice obtained at maturity; R2 was 0.906 (p < 0.01) to 0.964 (p < 0.001), and the RMSE value ranged from 2.00 to 6.10, at both the DBMs. In the methods employing the grain scanner, the correlations between the predicted and target grain rates at the same DBMs were lower; R2 was 0.556 (p = 0.054) to 0.777 (p < 0.01), the RMSE value was between 7.86 and 12.03. Thus, the methods using transverse section of premature grains developed in this study could be applied for predicting the occurrence of milky‐white rice a week to 10 DBM.

Occurrence of milky‐white rice can be predictable using transverse section of the premature grain.
The chalky zone detected inside the transparent area on the transverse section is the indicator.
The method is based on the regularity of starch accumulation from center towards peripheral in the grain.
This method will contribute to mitigation of grain breakage through postharvest management.
Psychosocial Correlates, Psychological Distress, and Quality of Life in Patients with Medically Unexplained Symptoms
Authors: Husain Muhammad Ishrat , Chaudhry Nasim , Morris Julie , Zafar Shehla Naeem , Jaffery Farhat , Rahman Raza , Duddu Venu , Husain Nusrat 
Published: April 2016

Objective To examine the psychosocial correlates and association of psychological distress and quality of life (QOL) in patients with medically unexplained symptoms (MUS) compared to those with medically explained symptoms (MES) in a primary care setting in Karachi, Pakistan. Methods A cross-sectional study of 472 patients attending GP clinics between March and August 2009 in Karachi. Participants completed questionnaires to assess demographic details, somatic symptoms, anxiety, depression, and QOL. The patients' GP recorded whether the presenting complaint was medically unexplained or medically explained. Results MUS subjects in our study were more educated, had better social support and fewer financial problems, were less depressed and had a better QOL than subjects who had medically explained symptoms (non-MUS). Both groups (MUS and non-MUS) were comparable in terms of anxiety and number of somatic symptoms, but non-MUS subjects were more depressed than the MUS group. In a regression analysis, the number of somatic symptoms and lower levels of anxiety predicted poorer QOL in this sample. Whether these symptoms were medically explained (or not) did not seem to contribute significantly to the QOL. Conclusion Our findings confirm that even in the developing world, patients with MUS are common among primary care attendees. However, patients with MUS in urban Karachi, Pakistan may differ from Western MUS subjects in the role of stress, support, and anxiety in their presentation, and may be reflective of a conceptually different group of difficulties.
Depressive Symptoms and Type 2 Diabetes Mellitus in Rural Appalachia: an 18-Month Follow-Up Study
Authors: de Groot Mary , Doyle Todd , Averyt Jennifer , Risaliti Carleen , Shubroo Jay 
Published: April 2016

Objective Despite high rates of diabetes and depression in rural areas, limited data exists to document patterns and predictors of depressive symptoms in rural patients with type 2 diabetes (T2DM). The purpose of this study was to assess the rates and predictors of co-morbid depressive symptoms over an 18-month period in a cohort of rural Appalachian adults with T2DM. Methods N = 100 adult T2DM patients were recruited from family medicine and endocrinology practices located in the rural Appalachian counties of southeastern Ohio and West Virginia. Data were collected using a longitudinal observational survey design. Results The sample consisted of predominantly White (93%) females (62%) who were married (71%), completed high school or less (48%), and had a mean age of 60 years ( SD 11). Mean BDI score was 14.0 ( SD 12) with 27% scoring in the moderate/severe range for depressive symptoms. A majority of patients (77%) reported depressive symptoms, at both time points, with 88% of these reporting consistent depressive symptoms in the year prior to study follow-up. Patients with depressive symptoms at Time 1 and Time 2 did not differ from other groups in the number of treatment strategies or medications used. Predictors of depressive symptoms in this group were increased diabetes treatment complexity (OR = 2.3), lack of home ownership (OR = 11.4), and decreased satisfaction with antidepressant medications (OR = 2.0; χ2 = 28.9, p < .0001). Conclusions Rural T2DM patients reported high rates of repeated depressive symptoms without corresponding rates of depression treatment. These patients may benefit from close monitoring and ongoing adjustment of their treatment for depression and diabetes by primary care providers.
Understanding Preventive Health Screening Services Use in Persons with Serious Mental Illness
Authors: Xiong Glen L. , Iosif Ana-Maria , Suo Shannon , Mccarron Robert M. , Koike Alan , Onate John , Carter Cameron S. 
Published: April 2016

Objective People with serious mental illness have reduced life expectancy, in large part due to reduced access to medical services and underutilization of preventive health services. This is a cross-sectional study that compared preventive services use in an integrated behavioral health primary care clinic (IBHPC) with two existing community mental health programs. Methods Participants completed questionnaires about preventive health services use that contained 33 questions about demographic clinical information, and use of preventive health services, from October 2010 to December 2012. Services examined included mammogram, Papanicolaou Test, prostate specific antigen, digital rectal exam, fecal occult blood test, and flexible sigmoidoscopy or colonoscopy; blood pressure, height and weight, cholesterol, and blood sugar for diabetes; and influenza immunization, Hepatitis C Virus (HCV), and Human Immunodeficiency Virus (HIV) antibodies. A health service utilization score was developed and used as primary outcome for data analyses. Results In the multivariate analyses female gender ( p < 0.05), race/ethnicity ( p = 0.01 for Asian, p = 0.04 for Hispanic/Latino, both compared to White), program type ( p < 0.001), and having a primary care provider ( p < 0.001) were significant predictors of higher services use. IBHPC was associated with higher overall service utilization compared to one community mental health program ( p < 0.001) but was similar when compared another ( p = 0.34). There was high variability in use of individual services among the clinical programs. Conclusion More studies are needed to examine the effectiveness of integrated care in improving use of health screening services. Characteristics of the clinic in relation to use of preventive services deserve further study.
Determinants and Consequences of Nonprofit Debt Ratings
Authors: Gaver Jennifer J. , Harris Erica E. , Im S. Mary 
Published: April 2016

SYNOPSIS
We use a comprehensive sample of over 400 nonprofit organizations that received a bond rating from Moody's or S&P between 1997 and 2010 to investigate the types of nonprofits that purchase a rating and the association between ratings and donations. Compared to organizations without ratings, our results indicate that bond ratings are purchased by larger organizations and those with more debt. We also find evidence that donors' use of information provided by bond ratings is limited to hospitals and universities. This result likely occurs because donors to hospitals and universities are more aware of debt ratings than donors to other nonprofit organizations. An implication is that nonprofits in other industries should consider disseminating bond rating information directly to potential donors as part of their fundraising efforts.
Patellofemoral Osteoarthritis: Are We Missing an Important Source of Symptoms After Anterior Cruciate Ligament Reconstruction?
Authors: Culvenor Adam G. , Crossley Kay M. 
Published: April 2016

Anterior cruciate ligament (ACL) rupture is a well-established risk factor for knee osteoarthritis (OA). Fifty to ninety percent of individuals will develop radiographic tibiofemoral OA within a decade after ACL injury and anterior cruciate ligament reconstruction (ACLR). Although less well recognized, radiographic patellofemoral OA is present in approximately 50% of individuals at more than 10 years after ACLR. This early-onset OA and its associated pain and functional limitations pose a particular challenge to younger adults with OA compared to an older OA population. Targeted interventions need to be developed to reduce the burden of early-onset OA following ACLR. Emerging evidence suggests that such interventions should target both the patellofemoral and tibiofemoral joints. J Orthop Sports Phys Ther 2016;46(4):232–234. doi:10.2519/jospt.2016.0603
Masseteric–facial nerve neurorrhaphy: results of a case series
Authors: Biglioli Federico , Colombo Valeria , Rabbiosi Dimitri , Tarabbia Filippo , Giovanditto Federica , Lozza Alessandro , Cupello Silvia , Mortini Pietro 
Published: April 2016

OBJECTIVE
Facial palsy is a well-known functional and esthetic problem that bothers most patients and affects their social relationships. When the time between the onset of paralysis and patient presentation is less than 18 months and the proximal stump of the injured facial nerve is not available, another nerve must be anastomosed to the facial nerve to reactivate its function. The masseteric nerve has recently gained popularity over the classic hypoglossus nerve as a new motor source because of its lower associated morbidity rate and the relative ease with which the patient can activate it. The aim of this work was to evaluate the effectiveness of masseteric–facial nerve neurorrhaphy for early facial reanimation.

METHODS
Thirty-four consecutive patients (21 females, 13 males) with early unilateral facial paralysis underwent masseteric–facial nerve neurorrhaphy in which an interpositional nerve graft of the great auricular or sural nerve was placed. The time between the onset of paralysis and surgery ranged from 2 to 18 months (mean 13.3 months). Electromyography revealed mimetic muscle fibrillations in all the patients. Before surgery, all patients had House-Brackmann Grade VI facial nerve dysfunction. Twelve months after the onset of postoperative facial nerve reactivation, each patient underwent a clinical examination using the modified House-Brackmann grading scale as a guide.

RESULTS
Overall, 91.2% of the patients experienced facial nerve function reactivation. Facial recovery began within 2–12 months (mean 6.3 months) with the restoration of facial symmetry at rest. According to the modified House-Brackmann grading scale, 5.9% of the patients had Grade I function, 61.8% Grade II, 20.6% Grade III, 2.9% Grade V, and 8.8% Grade VI. The morbidity rate was low; none of the patients could feel the loss of masseteric nerve function. There were only a few complications, including 1 case of postoperative bleeding (2.9%) and 2 local infections (5.9%), and a few patients complained about partial loss of sensitivity of the earlobe or a small area of the ankle and foot, depending on whether great auricular or sural nerves were harvested.

CONCLUSIONS
The surgical technique described here seems to be efficient for the early treatment of facial paralysis and results in very little morbidity.
Patterns of recurrence and survival in sporadic, neurofibromatosis Type 1–associated, and radiation-associated malignant peripheral nerve sheath tumors
Authors: Watson Kelsey L. , Al Sannaa Ghadah A. , Kivlin Christine M. , Ingram Davis R. , Landers Sharon M. , Roland Christina L. , Cormier Janice N. , Hunt Kelly K. , Feig Barry W. , Ashleigh Guadagnolo B. , Bishop Andrew J. , Wang Wei-Lien , Slopis John M. , McCutcheon Ian E. , Lazar Alexandar J. , Torres Keila E. 
Published: April 2016

OBJECTIVE
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive group of soft tissue sarcomas that can arise sporadically, in the context of neurofibromatosis Type 1 (NF1) or at a site of prior irradiation. Large series profiling the features and outcomes of sporadic, NF1-associated, and radiation-associated MPNSTs are limited. The goal of this study was to elucidate differences between MPNST etiologies in a large single-institution retrospective study.

METHODS
Patients (n = 317) were identified through the tumor registry of The University of Texas MD Anderson Cancer Center. Clinicopathological features were retrospectively collected. Features were compared among MPNST subtypes for patients who had sufficient clinical history (n = 289), and clinicopathological features were used to identify adverse predictors of recurrence and survival outcomes.

RESULTS
Five-year local recurrence-free survival (LRFS), distant recurrence-free survival (DRFS), and disease-specific survival (DSS) estimates were 56.6%, 49.6%, and 53.6%, respectively, for the high-grade MPNST cohort. Five-year DSS was lower in NF1-associated and radiation-associated MPNST than in sporadic MPNST (52%, 47%, and 67%, respectively, p = 0.140). Patients with radiation-associated MPNST had worse 5-year LRFS than those with the sporadic and NF1-associated subtypes (RT-associated vs sporadic, p = 0.010; RT-associated vs NF1-associated, p = 0.232). Truncally located tumors, positive surgical margins, local recurrence, and metastasis were predictors of adverse DSS in multivariate analysis.

CONCLUSIONS
Radiation-associated MPNSTs are associated with poorer local recurrence-free and disease-specific survival than sporadic and NF1-associated tumors. NF1-associated MPNSTs may have worse survival outcomes owing to large tumor size, compromising truncal location, and lower rate of negative resection margins compared with sporadic tumors.