bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of biomarkers of inflammation and MRI technique for the early detection of cystinosis-associated myopathy
Authors: Helmy Rasha , Mahmoud Rasha Selim , Elmonem Mohamed A. , Emadeldin Sally , Soliman Neveen Abd Elmonem 
Published: September 2024

Abstract
Background
Cystinosis is an autosomal recessive lysosomal storage disorder caused by cystine crystals accumulation within lysosomes resulting in multi-organ dysfunction. Infantile nephropathic cystinosis is the most common phenotype of the disease. Cystinosis distal myopathy was first described in 1994 with a 24% prevalence in cystinosis adult patients.

Methods
We prospectively evaluated the clinical, biochemical, and radiological data of 22 nephropathic cystinosis pediatric patients from 19 unrelated families (17 males and 5 females, their ages 105.7 ± 41.5 months) recruited at the cystinosis clinic at Cairo University Children’s Hospital. Biochemical assessment included several inflammatory biomarkers, such as CRP, ESR, chitotriosidase, and galectin-3. We further performed conventional MRI for the muscles of both upper and lower limbs for potential detection of early myopathic involvement. We compared these findings with 44 CKD children as pathological controls and 22 healthy pediatric controls.

Results
Clinically, no evidence of neuromuscular involvement was detected in our cystinosis pediatric cohort. Chitotriosidase was elevated significantly in cystinosis patients compared to CKD controls. Regarding MRI, morphologically, there were no significant differences between the muscles of cystinosis patients and healthy controls.

Conclusion
A significantly higher chitotriosidase activity in cystinosis patients seems to better represent the overall disease burden and cannot be linked to neuromuscular involvement. MRI findings in muscles of the cystinosis cohort are not striking and indicate no early changes at a younger age. Follow-up and further studies for higher age groups are required to accurately elucidate the MRI’s role in assessing cystinosis myopathy.
Listeria monocytogenes brain abscess in a patient with systemic lupus erythematosus (SLE): a case report
Authors: Rasad Nur Sakinah Abd , Omar Nurul Akhmar , Osman Noor Diyana 
Published: September 2024

Abstract
Background
Brain abscesses caused by Listeria monocytogenes (L. monocytogenes) are very rare and lead to high mortality risk. To our knowledge, no prior studies have been reported in Malaysia on the brain abscess caused by L. monocytogenes.

Case presentation
In this case report, we present 33-year-old female patient with known case of systemic lupus erythematosus (SLE) whom developed fever and left-sided body weakness. Initially, she was suspected to have high-grade glioma or lymphoma because the imaging shows multiple irregulars peripherally enhancing intra axial lesions with marked vasogenic edema. However, tissue biopsy confirmed L. monocytogenes infection. This report also presents the CT and MRI findings of this SLE patient with unusual L. monocytogenes brain abscesses. The patient was then treated with IV ampicillin, IV meropenem and IV amphotericin.

Conclusions
Brain abscess caused by L. monocytogenes is uncommon and lethal. Therefore, it should be carefully examined in patients who are at high risk of listeriosis.
Observer-based robust servomechanism control of a three-phase induction motor drive
Authors: Friday Itodo Victory , Shehu Gaddafi Sani , Olarinoye Gbenga Abidemi , Jomoh Boyi 
Published: September 2024

AbstractInduction motors (IMs) are widely used in industrial applications, but harmonic distortion in IM drives can lead to inefficiencies and reduced lifespan. Traditional control strategies and filtering methods have limitations in mitigating lower-order harmonics, particularly the 5th harmonic, which can generate reverse torque and increase overheating risk. Existing solutions often struggle to fully address these issues, especially in high-power applications with dynamic loading conditions. This paper proposes a control strategy to reduce voltage and current harmonics in a Z-source inverter (ZSI)-fed IM drive. The system incorporates an observer-based output feedback robust servomechanism controller, designed using Linear Quadratic Regulator (LQR) and Linear Matrix Inequality (LMI) techniques. It ensures closed-loop stability, precise tracking regulation, and effective disturbance rejection, while also featuring a speed adaptation mechanism for sensorless operation. Simulation results demonstrate significant harmonic mitigation, with the controller achieving 1.01% lower voltage THD and 1.03% lower current THD compared to conventional approaches. This improvement aligns with industry standards and outperforms several existing techniques. The proposed method contributes a comprehensive solution for harmonic mitigation in high-power IM drives, applicable to various industrial applications requiring high-quality power and precise speed control.
Dynamic treatment regimes: practical design considerations
Authors: Lavori Philip W , Dawson Ree 
Published: September 2024

Background Clinical management of chronic disease requires a dynamic treatment regime (DTR): rules for choosing the new treatment based on the history of response to past treatments. Estimating and comparing the effects of DTRs from a sample of observed trajectories of treatment and outcome depends on the untestable assumption that new treatments are assigned independently of potential future responses to treatment, conditional on the history of treatments and response to date (“sequential ignorability”). In longitudinal observational studies, sequential ignorability must be assumed, while randomization of dynamic regimes can guarantee it. Methods Using several clinical examples, we describe the simplest randomized experimental designs for comparing DTRs. We begin by considering an initial treatment A and a second treatment B, and discuss how a dynamic treatment regime that starts with A and leads (sometimes) to B, might be compared to either fixed treatment A or B. We also illustrate the problem of finding the optimal sequence of treatments in a DTR, when there are several choices. We describe and contrast two ways of incorporating randomization into studies to compare such regimes: baseline randomization among DTRs versus randomization at the decision points (sequentially randomized designs). Conclusions We discuss estimation and inference from both baseline randomized and sequentially randomized designs and conclude with a discussion of the differences between the experimental and observational approaches to optimizing and comparing dynamic treatment regimes.
Putting Back Together
Authors: Rymhs Deena 
Published: September 2024

Abstract
Composed of diptych photographs stitched together in a poetic travelogue through nuclear-infused (Indigenous) lands, annie ross's Pots and Other Living Beings reenvisions social and ecological relations, value structures, and knowledge frameworks in its encounter with violated landscapes of the American Southwest. In its embrace of the blighted remainders of nuclear testing, industry, and consumerism, Pots and Other Living Beings is not a typical “environmental” text. Like ross's weaving and visual installations, this work is alive to relations of reciprocity and kinship with more-than-human worlds in what one could best describe as a spiritual engagement with the abandoned, unremarked leavings of nuclearization, industrial capitalism, and waste cultures.
Sarcopenia Predicts the Development of Early Adjacent Segment Disease After Transforaminal Lumbar Interbody Fusion
Authors: Wilkinson Brandon M. , Maloney Brendan , Li Jian , Polavarapu Hanish , Draytsel Dan , Hazama Ali 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Predicting the development of adjacent segment disease (ASD) after lumbar spine fusion would help guide preoperative and postoperative therapies to prevent reoperation. We sought to evaluate whether sarcopenia predicts the development of early ASD after transforaminal lumbar interbody fusion (TLIF).

METHODS:
Retrospective data were collected from 109 patients who underwent TLIF from 2013 to 2023. Patients older than 18 years who underwent elective posterior midline approach TLIF were included. Patients with prior lumbar instrumented fusions, cases of trauma, central nervous system infection, cancer, or long-construct thoracolumbar deformity corrections and those who lacked sufficient follow-up were excluded. The primary outcome was radiographic ASD development within 3 years of surgery. Psoas volumetric measurements were recorded from the most recent preoperative MRI. Odds ratios were calculated with logistic regression analyses.

RESULTS:
In 109 patients undergoing elective TLIF, 22 (20.2%) developed ASD within 3 years. Gender, body mass index, and extent of surgery were not associated with ASD development. Multivariate analysis showed left/right psoas cross-sectional area, and psoas:vertebral body ratio (P:VBR) predicted early ASD (P < .0001). Sarcopenia was further categorized as having bilateral P:VBR ≥1 SD below gender mean (T-score −1). Of 18 sarcopenic patients, 15 developed early ASD (83.33%) vs 7 of 91 nonsarcopenic patients (7.69%; P < .0001). Postoperative mismatch between pelvic incidence and lumbar lordosis was predictive of ASD on univariate (P = .0480) but not multivariate analysis. Pelvic tilt and lumbar lordosis postoperatively were not associated with early ASD.

CONCLUSION:
Sarcopenia, measured by decreased psoas area and P:VBR, predicts ASD formation within 3 years of surgery. Morphometric analysis of psoas size is a simple tool to identify patients at risk of developing ASD. This information can potentially guide preoperative and postoperative therapies, affect surgical decision making, and effectively counsel patients on risks of reoperation.
The Relationship between E-Health Literacy and Educational Participation Motivation among Elderly Individuals: The Chained Mediating Effects of Self-Identity and Social Capital
Authors: Cai Shaolian , Du Juan , Chen Xingqiang , Li Enliang , Chen Yufang 
Published: September 2024

Aims/Background In light of the increased utilization of digital technology among the elderly population, understanding the relationship between e-health literacy, self-identity, social capital, and educational participation motivation has become crucial. This study aims to investigate these relationships and explore the mediating effects of self-identity and social capital on the elderly population. By shedding light on these aspects, the study seeks to contribute to the existing knowledge base and inform intervention strategies to enhance the elderly individuals’ overall well-being and engagement with digital health resources. Methods A questionnaire survey was conducted in a sample consisting of 578 elderly participants. Data of the surveyed variables were analyzed. Mediating effect analysis methods were employed to explore the mediating roles of self-identity and social capital in the relationship between e-health literacy and educational participation motivation among the elderly individuals. Results The results revealed a significant positive correlation between e-health literacy, self-identity, social capital, and educational participation motivation among elderly individuals. Furthermore, self-identity and social capital were found to play significant mediating roles between e-health literacy and educational participation motivation. Specifically, self-identity and social capital acted as complete mediators, with a mediating effect value of 0.61, between e-health literacy and educational participation motivation. Additionally, the chained mediating effect of self-identity and social capital was also significant. Conclusion This study demonstrated that e-health literacy and educational participation motivation are closely intertwined, with self-identity and social capital acting as the mediators in this association, in the elderly population, providing valuable guidance for enhancing the health and quality of life and offering insightful references for the development and implementation of relevant policies.
Preoperative Prediction of Her-2 and Ki-67 Status in Gastric Cancer Using 18F-FDG PET/CT Radiomics Features of Visceral Adipose Tissue
Authors: Chen Demei , Zhou Rui , Li Bo 
Published: September 2024

Aims/Background Immunohistochemistry (IHC) is the main method to detect human epidermal growth factor receptor 2 (Her-2) and Ki-67 expression levels. However, IHC is invasive and cannot reflect their expression status in real-time. This study aimed to build radiomics models based on visceral adipose tissue (VAT)’s 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging, and to evaluate the relationship between radiomics features of VAT and positive expression of Her-2 and Ki-67 in gastric cancer (GC). Methods Ninety patients with GC were enrolled in this study. 18F-FDG PET/CT radiomics features were calculated using the PyRadiomics package. Two methods were employed to reduce radiomics features. The machine learning models, logistic regression (LR), and support vector machine (SVM), were constructed and estimated by the receiver operator characteristic (ROC) curve. The correlation of outstanding features with Ki-67 and Her-2 expression status was evaluated. Results For the Ki-67 set, the area under of the receiver operator characteristic curve (AUC) and accuracy were 0.86 and 0.79 for the LR model and 0.83 and 0.69 for the SVM model. For the Her-2 set, the AUC and accuracy were 0.84 and 0.86 for the LR model and 0.65 and 0.85 for the SVM model. The LR model for Ki-67 exhibited outstanding prediction performance. Three wavelet transform features were correlated with Her-2 expression status (p all < 0.001), and one wavelet transform feature was correlated with the expression status of Ki-67 (p = 0.042). Conclusion 18F-FDG PET/CT-based radiomics models of VAT demonstrate good performance in predicting Her-2 and Ki-67 expression status in patients with GC. Radiomics features can be used as imaging biomarkers for GC.
Persistent Fistula Closure After Endoscopic Ultrasound-Directed Transgastric Endoscopic Retrograde Cholangiopancreatography by Postinfarct Ventricular Septal Defect Occluder
Authors: Aghaie Meybodi Mohamad , Johal Amitpal S. , Abdulsamad Molham 
Published: September 2024

ABSTRACT
A gastrogastric fistula is a delayed complication of the endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography. Endoscopic closure of these fistulae poses a significant challenge, and surgical intervention may be required in some patients. In this study, we discuss the case of a 69-year-old woman with persistent fistula following the endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography procedure. Despite the failure of conventional advanced endoscopic fistula closure methods, successful closure of the fistula was achieved using a postinfarct ventricular septal defect occluder.
Absolute quantitation of human serum cystatin C: candidate reference method by 15N-labeled recombinant protein isotope dilution UPLC-MS/MS
Authors: Zhang Qiaoxuan , Zhan Min , Peng Xiongqiang , Jin Xing , Yan Jun , Zhang Pengwei , Zhuang Junhua , Han Liqiao , Huang Xianzhang 
Published: September 2024

Abstract

Objectives
Serum cystatin C (CysC) is a reliable and ideal endogenous marker for accurately assessing early changes in glomerular filtration rate (GFR), surpassing the limitations of creatinine-based estimated GFR. To improve the precision of GFR calculation, the development of strategies for accurately measuring serum CysC is crucial.

Methods
In this study, the full-length CysC pure product and fully recombinant 15N-labeled CysC internal standard were subjected to protein cleavage. Subsequently, an LC-MS/MS method was developed for the absolute quantification of serum CysC. The traceability of the method was assigned calibrator using the amino acid reference measurement procedure (RMP). It involved calibrating the instrument using an amino acid reference material with known amino acid concentrations for calibration and comparison purposes.

Results
The total imprecision of the method was determined to be ≤8.2 %, and a lower functional limit of quantification (LLoQ) was achieved. The recoveries ranged from 97.36 to 103.26 %. The relative bias between this candidate RMP for measurement of ERM-DA471-IFCC and the target value was 1.74 %. The linearity response was observed within the concentration range of 0.21–10.13 mg/L, with a high R2 value of 0.999. The results obtained using our method was consistent with those obtained using other certified RMPs.

Conclusions
With the establishment of this highly selective and accurate serum CysC measurement method, it is now possible to assess the correlation between immunoassay results of serum CysC and the intended target when discrepancies are suspected in the clinical setting.
Some Hardy's inequalities on conformable fractional calculus
Authors: AlNemer Ghada , Saker Samir H. , Ashry Gehad M. , Zakarya Mohammed , Rezk Haytham M. , Kenawy Mohammed R. 
Published: September 2024

Abstract
In this article, we will demonstrate some Hardy’s inequalities by utilizing Hölder inequality, integration by parts, and chain rule of the conformable fractional calculus. When

α
=
1

\alpha =1

, we can obtain some of classical Copson’s and Hardy’s inequalities. In the end, we will obtain an application of Hardy’s inequality utilizing the conformable fractional calculus.
Modeling the importance of physician training in practice location for Ohio otolaryngologists
Authors: Borgemenke Samuel , Newsom D’Nair , Scheatzle Patrick , Durstock Nicholas , Beverly Elizabeth A. 
Published: September 2024

Abstract

Context
Underserved communities in southeastern Ohio and Appalachia face significant healthcare accessibility challenges, with the Midwest offering a lower density of healthcare providers compared to coastal regions. Specifically, underserved communities in southeastern Ohio and Appalachia are disadvantaged in otolaryngology care.

Objectives
This analysis aims to identify factors that lead otolaryngologists to a respective practice location, and if any of that influence comes from where otolaryngologists completed their medical education.

Methods
The proportion of otolaryngologists who performed medical school, residency, and/or fellowship in Ohio was analyzed utilizing a three-sample test for equality. Multivariate logistic regression and Pearson prediction models were produced to analyze the impact of performing medical training (medical school, residency, and fellowship) in Ohio.

Results
Going to medical school in Ohio significantly increases the odds of going to an otolaryngology residency in the state (p<0.001). Moreover, between medical school and residency, medical school was a significantly better predictor of otolaryngologists practicing in Appalachia (Δ Bayesian Information Criterion [BIC]>2) and southeast Ohio (ΔBIC>10). Medical school in state was also a better predictor of percent rural and median household income than residency (ΔBIC>10). The multivariate model of medical school and residency was significantly better than either predictor alone for the population (ΔBIC>2). All models predicting percent rural were significantly improved with the addition of a Doctor of Osteopathy (DO) degree (ΔBIC>10).

Conclusions
Where physicians complete their medical training (medical school, residency, and fellowship) in state has a significant impact on predicting their future place of practice. This study found that the location of such training has a positive predictive nature as to whether that physician will practice in a rural and underserved area in the future. Notably, the addition of being licensed as a DO also increased the probability of that physician practicing in a rural area.
Prediction of intrapartum caesarean section in vaginal breech birth: development of models for nulliparous and multiparous women
Authors: Lia Massimiliano , Költzsch Elisabeth , Martin Mireille , Kabbani Noura , Stepan Holger 
Published: September 2024

Abstract

Objectives
To develop prediction models for intrapartum caesarean section in vaginal breech birth.

Methods
This single-center cohort-study included 262 nulliparous and 230 multiparous women attempting vaginal breech birth. For both groups, we developed and (internally) validated three models for the prediction of intrapartum cesarean section.

Results
The prediction model for nulliparous women (AUC: 0.67) included epidural analgesia (aOR 2.14; p=0.01), maternal height (aOR 0.64 per 10 cm; p=0.08), birthweight ≥3.8 kg (aOR 2.45; p=0.03) and an interaction term describing the effect of OC if birthweight is ≥3.8 kg (aOR 0.24; p=0.04). An alternative model for nulliparous women which, instead of birthweight, included fetal abdominal circumference with a cut-off at 34 cm (aOR 1.93; p=0.04), showed similar performance (AUC: 0.68). The prediction model for multiparous women (AUC: 0.77) included prelabor rupture of membranes (aOR 0.31; p=0.03), epidural analgesia (aOR 2.42; p=0.07), maternal BMI (aOR 2.92 per 10 kg/m2; p=0.01) and maternal age (aOR 3.17 per decade; p=0.06).

Conclusions
Our prediction models show the most relevant risk factors associated with intrapartum cesarean section in vaginal breech birth for both nulliparous and multiparous women. Importantly, this study clarifies the role of the OC by showing that this parameter is only associated with intrapartum cesarean section if birthweight is above 3.8 kg (or abdominal circumference is above 34 cm). Conversely, knowing the OC when the birthweight is less than 3.8 kg (or abdominal circumference is less than 34 cm) did not improve prediction of this surgical outcome.
The acquisition of speaking fundamental frequency (F0) features in Cantonese and English by simultaneous bilingual children
Authors: Zhu Yanjiao 
Published: September 2024

Abstract
This exploratory study conducted an acoustic analysis of conversational speech produced by three-year-old children who are bilingual in Cantonese and English, as well as of children who are monolingual in one of those languages. Three fundamental frequency features of speech (mean F0, pitch sigma, and F0 range) were measured and compared between the bilingual and monolingual children, as well as within the bilingual children’s two languages. The results demonstrate significant individual variations. Some of the bilingual children exhibited differential F0 features in both languages, while others did not. Language dominance also emerges. In their dominant language Cantonese, the bilingual children produced the F0 patterns the same way as monolingual Cantonese children, whereas in their nondominant language English, the F0 features were different from those of monolingual English children. The findings suggest that three-year-old bilingual children have started developing distinct prosodic patterns for their two languages. However, achieving full command of prosody in both languages remains a prolonged process.