bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Treatment of Rosai-Dorfman Intracranial Disease: Case Report and Literature Review
Authors: Hilleshein Klisman , Santin Vinícius , Silva Fabrício 
Published: March 2016

AbstractRosai-Dorfman disease is a benign lymphoproliferative disease with rare occurrence in the overall population. The characteristic findings of the disease are emperipolesis on microscopy and S-100 protein positivity on immunohistochemistry. The present report describes the case of a 57-year-old man who presented with repeated seizures, urinary retention, and ataxia. Satisfactory results were obtained with surgical treatment. The diagnosis was confirmed by immunohistochemistry.
Sub-kT/q subthreshold slope p-metal-oxide-semiconductor field-effect transistors with single-grained Pb(Zr,Ti)O3 featuring a highly reliable negative capacitance
Authors: Park Jae Hyo , Joo Seung Ki 
Published: March 2016

A reliable on/off switching with an sub-kT/q subthreshold slope (38 mV/dec at room temperature) is experimentally demonstrated with using selectively nucleated laterally crystallized single-grain Pb(Zr,Ti)O3 (PZT) ferroelectric and ZrTiO4 paraelectric thin-film. The combination of ferroelectric and paraelectric thin-film is enabled to form a negative capacitance (NC) at the weak inversion region. However, the PZT grain-boundary easily degrades the NC properties after switching the on/off more than 108 times. It is found that the polarization of PZT is diminished from the path of grain-boundary. Here, we effectively suppress the degradation of NC MOS-FET which did not showed any fatigue even after 108 on/off switching.
At the request of the authors this article is retracted due to duplication of figures and significant overlap with other publications by the authors and because of concerns about the accuracy of the description of the devices and materials from which the reported results were obtained. The authors recognize that these represent serious errors and sincerely apologize for any inconvenience they may have caused. The article is retracted from the scientific record with effect from 17 February 2017.
Allosteric switch regulates protein–protein binding through collective motion
Authors: Smith Colin A. , Ban David , Pratihar Supriya , Giller Karin , Paulat Maria , Becker Stefan , Griesinger Christian , Lee Donghan , de Groot Bert L. 
Published: March 2016

Significance
Within biological molecules, a change in shape at one site affecting a distant site is called allostery, and is a process critical for sustaining life. At the atomic level, the means of communication is often not well understood. We identify a previously unidentified way for allostery to occur through collective motion of an entire protein structure. Together with newly developed computational algorithms, we determine atomic structures representing this previously invisible allosteric motion. This allosteric network is shown to be an intrinsic property of the protein and important for enabling binding to different protein partners. The nature of this motion, along with the tools we developed to detect it, should prove invaluable for understanding living organisms and developing new therapeutics.
Molecular hydrogen and catalytic combustion in the production of hyperpolarized83Kr and129Xe MRI contrast agents
Authors: Rogers Nicola J. , Hill-Casey Fraser , Stupic Karl F. , Six Joseph S. , Lesbats Clémentine , Rigby Sean P. , Fraissard Jacques , Pavlovskaya Galina E. , Meersmann Thomas 
Published: March 2016

SignificanceThe high signal intensity associated with magnetic resonance of hyperpolarized129Xe has enabled countless applications ranging from materials science to biomedical MRI of the lung and brain. New modalities are constantly emerging; for example, hyperpolarized129Xe biosensors are of potential interest for molecular imaging of biomarker distribution in organs. Hyperpolarized83Kr shows promise as novel surface-sensitive contrast agent for pulmonary MRI but previous work was limited to excised lungs. This work reports a previously unexplored approach in the generation of hyperpolarized contrast agents that makes highly concentrated hyperpolarized83Kr available for the first time, to our knowledge. The results also provide the basis for on-demand flow production of highly concentrated hyperpolarized129Xe for in situ process monitoring and in vivo molecular imaging.
Analysis of CFSE time-series data using division-, age- and label-structured population models
Authors: Hross Sabrina , Hasenauer Jan 
Published: March 2016

AbstractMotivation: In vitro and in vivo cell proliferation is often studied using the dye carboxyfluorescein succinimidyl ester (CFSE). The CFSE time-series data provide information about the proliferation history of populations of cells. While the experimental procedures are well established and widely used, the analysis of CFSE time-series data is still challenging. Many available analysis tools do not account for cell age and employ optimization methods that are inefficient (or even unreliable).Results: We present a new model-based analysis method for CFSE time-series data. This method uses a flexible description of proliferating cell populations, namely, a division-, age- and label-structured population model. Efficient maximum likelihood and Bayesian estimation algorithms are introduced to infer the model parameters and their uncertainties. These methods exploit the forward sensitivity equations of the underlying partial differential equation model for efficient and accurate gradient calculation, thereby improving computational efficiency and reliability compared with alternative approaches and accelerating uncertainty analysis. The performance of the method is assessed by studying a dataset for immune cell proliferation. This revealed the importance of different factors on the proliferation rates of individual cells. Among others, the predominate effect of cell age on the division rate is found, which was not revealed by available computational methods.Availability and implementation: The MATLAB source code implementing the models and algorithms is available from http://janhasenauer.github.io/ShAPE-DALSP/.Contact: jan.hasenauer@helmholtz-muenchen.deSupplementary information: Supplementary data are available at Bioinformatics online.
Different Mortality Time Points in Critical Care Trials: Current Practice and Influence on Effect Estimates in Meta-Analyses
Authors: Roth Dominik , Heidinger Benedikt , Havel Christof , Herkner Harald 
Published: March 2016

Objective:
Mortality is frequently used as an outcome in critical care trials, being a patient-orientated variable and robust against information/selection bias. Mortality frequency, however, should be measured at a defined time point of follow-up. Practice of meta-analysis shows that follow-up times of trials in critical care medicine differ substantially. This may have substantial implications on potential pooling of effect estimates. We aimed to describe the current practice of mortality follow-up time definitions in a representative sample of published critical care randomized controlled trials and to analyze the influence of different follow-up times on subsequently pooled effect estimates.

Data Sources:
Cochrane CENTRAL, EMBASE, MEDLINE, PASCAL Biomed, and PsycINFO.

Study Selection:
Databases were searched for critical care randomized controlled trials published after 2000. A random sample of 50% was drawn for further review.

Data Extraction:
Study characteristics were extracted, as well as the number and time points of mortality ascertainment. Additional data were extracted from Kaplan-Meier plots, as available.

Data Synthesis:
Meta-regression and multilevel mixed-effects linear regression were used to analyze the influence of follow-up time (independent variable) on deviation of pooled risk ratios from study baseline (dependent variable). From 9,246 retrieved references, we included 106 studies representing 63,713 participants. Among these, 45 studies (43%) reported more than one time point, with 24 different time points at all, only three (28, 30, and 90 d) being reported in more than 10% of studies. Limiting meta-analyses to only one predefined time point would reduce the number of eligible studies by at least 60%. No influence of time points on meta-analytic summary effect estimates was found.

Conclusions:
In a large sample of critical care randomized controlled trials, numerous different mortality time points are reported. Mortality time points did not influence pooled point estimates of the effects. Consequently, it seems possible to pool effect estimates, which in turn will increase the precision of these effect estimates.
Biopsy‐Induced Duodenal Hematoma Is Not an Infrequent Complication Favored by Bone Marrow Transplantation
Authors: Sierra Anaïs , Ecochard‐Dugelay Emmanuelle , Bellaïche Marc , Tilea Bogdana , Cavé Hélène , Viala Jérôme 
Published: March 2016

ABSTRACTObjectives:Intraduodenal hematoma (IDH) is an uncommon complication of endoscopic duodenal biopsy that can cause severe obstruction of the digestive, biliary, or pancreatic tracts. We aimed to analyze the risk factors and outcomes of biopsy‐induced IDH in our series.Methods:Between 2010 and 2014, a retrospective chart review was conducted for all children younger than 18 years of age treated for IDH. We collected their data in our tertiary pediatric center and compared them to those of controls matched for age, sex, and pathology.Results:Among 2705 upper nontherapeutic endoscopies and 1163 duodenal biopsies, 7 IDH occurred in 6 children suspected of developing graft‐versus‐host disease (GVHD) after bone marrow transplantation (BMT) and in 1 patient with Noonan syndrome. The IDH prevalence was significantly higher after BMT compared to children who did not undergo grafting (7% vs 0.1%; P = 7.9 × 10−7; odds ratio = 82). After a median delay of 48 hours, patients developed intestinal obstruction with abdominal pain and vomiting. The diagnosis was confirmed by using ultrasonography or computed tomography scans. Acute pancreatitis was determined in 3 out of 7 patients. Conservative treatment allowed complete resolution in all patients.Conclusions:IDH is not an infrequent complication of endoscopic duodenal biopsy, especially in patients who undergo BMT. Endoscopists should be especially careful during the duodenal biopsy procedure in these patients. With no early perforation due to post‐biopsy IDH reported, the prognosis is good and conservative management generally leads to resolution of the symptoms in 2 to 3 weeks.
Discovery of Primary, Cofactor, and Novel Transcription Factor Binding Site Motifs by Recursive, Thresholded Entropy Minimization
Authors: Lu Ruipeng , Mucaki Eliseos , Rogan Peter K. 
Published: March 2016

ABSTRACTData from ChIP-seq experiments can determine the genome-wide binding specificities of transcription factors (TFs) and other regulatory proteins. In the present study, we analyzed 745 ENCODE ChIP-seq peak datasets of 189 human TFs with a novel motif discovery method that is based on recursive, thresholded entropy minimization. This method is able to distinguish correct information models from noisy motifs, quantify the strengths of individual sites based on affinity, and detect adjacent cofactor binding sites that coordinate with primary TFs. We derived homogeneous and bipartite information models for 89 sequence-specific TFs, which enabled discovery of 24 cofactor motifs for 118 TFs, and revealed 6 high-confidence novel motifs. The reliability and accuracy of these models were determined via three independent quality control criteria, including the detection of experimentally proven binding sites, comparison with previously published motifs and statistical analyses. We also predict previously unreported TF cobinding interactions, and new components of known TF complexes. Because they are based on information theory, the derived models constitute a powerful tool for detecting and predicting the effects of variants in known binding sites, and predicting previously unrecognized binding sites and target genes.
Brain oscillations track the formation of episodic memories in the real world
Authors: Griffiths Benjamin , Mazaheri Ali , Debener Stefan , Hanslmayr Simon 
Published: March 2016

AbstractDespite the well-known influence of environmental context on episodic memory, little has been done to enhance contextual richness within the lab. This leaves a blind spot lingering over the neuronal correlates of episodic memory formation in the real world. To address this, we presented participants with series of words to memorise along a pre-designated route across campus. Meanwhile, a mobile EEG system acquired the associated neural activity. Replicating lab-based subsequent memory effects (SMEs), we identified significant low-frequency power decreases, including beta power decreases over the left inferior frontal gyrus. Additionally, the paradigm enabled us to dissociate the oscillatory correlates of temporal and spatial clustering. Specifically, we found spatially clustered items exhibited significantly greater theta power decreases within the left medial temporal lobe than temporally clustered items. These findings go beyond lab-based studies, which are limited in their capabilities to investigate environmental contextual factors that guide memory formation.
Learning environment and student effort
Authors: Hopland Arnt O. , Nyhus Ole Henning 
Published: March 2016

Purpose
– The purpose of this paper is to explore the relationship between satisfaction with learning environment and student effort, both in class and with homework assignments.

Design/methodology/approach
– The authors use data from a nationwide and compulsory survey to analyze the relationship between learning environment and student effort. The survey covers all students attending the seventh (last year of primary school) and tenth (last year of lower secondary school) grades in Norwegian compulsory education. Since the survey has been conducted every year since 2006/2007, we can apply panel data methods to reduce the potential for omitted variable problems.

Findings
– Student satisfaction with teacher guidance, materials and social environment plays an important role in stimulating effort both in class and with homework. Satisfaction with physical work conditions is of less importance, but does stimulate in-class effort among the younger students. Heterogeneity across the genders for tenth graders is also observed. In particular, bullying and satisfaction with teacher guidance are more important determinants for males’ than for females’ effort.

Practical implications
– The results indicate that school managers should focus attention on improving not only the quality of teachers and teaching materials, but also the social environment at the school in order to stimulate more student effort.

Originality/value
– The results contribute to the literature studying student effort and educational outcomes by providing information on how different school factors affect student effort.
Looking for an emergency door
Authors: Rossi Paolo 
Published: March 2016

Purpose
– The paper investigates the role of information asymmetries and sensegiving processes of citizens claiming for social services. The purpose of this paper is to highlight the relevance of applicants’ agency, since it has been generally neglected in the analysis of social services provision. On the contrary, the paper proposes an alternative view, considering applicants as actors who are able to develop dialectic strategies for claiming specific forms of social assistance.

Design/methodology/approach
– The paper is based on a qualitative research, conducted following an inductive approach. The data have been collected in three different Italian municipalities, where the researcher has been the opportunity to perform a period of observation of the interviews between the social workers of the local social services department and the citizens applying for social assistance.

Findings
– The findings of the research point out that informational asymmetries play an ambivalent role in the definition of applicant’s strategies, since they represent an ambivalent and dynamic factor, rather than a mere source of disadvantage for the user. From this viewpoint, the citizens’ possibilities to access to social assistance are shaped by both institutional and dialectic factors: on the one hand, access to social assistance relies on specific criteria of eligibility (institutionally defined), but on the other hand the access is the outcome of situated sensegiving processes, performed by both the applicants and the gatekeepers of social services during their encounters.

Research limitations/implications
– The research is based on the analysis of a small number of cases, within a context that is characterized by a high level of organizational and professional discretion in the regulation of the provision of social assistance.

Practical implications
– The findings of the research urge policy maker to re-consider applicants as strategic actors and opens the space for the development of new options of regulation of the delivery of social services.

Social implications
– The paper suggests to consider the applicants for social services as people who, although in a condition of need, are capable to identify specific forms of assistance. From this point of view, informational asymmetries are not be considered as a stigmatic issue, but as a space which calls for further and less superficial investigation.

Originality/value
– The paper challenges some of the most taken-for-granted theoretical assumptions in the analysis of the regulation of the access to social assistance. First, it proposes a dynamic interpretation of the notion of informational asymmetries, considering them as a space for action, rather than a binding factor; second, it emphasizes the relevance of user’s agency in the access to welfare services, that is generally neglected since most analyses focus on professional discretion disregarding the hypothesis of the user as a strategic actor.
Wearable devices to support rehabilitation and social care
Authors: Doughty Kevin , Appleby Alistair 
Published: March 2016

Purpose
– The purpose of this paper is to provide a review of the use of wearable technologies that focuses on applications that tackle sensory and communication deficits, physical disabilities and alarm and activity monitoring. It is intended to promote the introduction of more wearable approaches to providing assistive technologies because of their benefits in utilisation and aesthetic appeal.

Design/methodology/approach
– The approach involves a comparison of different types of portable device in order to identify different groups that may be beneficial to different application areas. Recent advances are then considered for each area.

Findings
– The work demonstrates that the use of wearable AT device is increasing due to improvements in materials, battery power and connected intelligence such as smartphones. They will allow new devices to be introduced that are smaller, lighter and more usable.

Practical implications
– Utilisation of assistive technologies is likely to improve as wearable devices become the norm across a wide range of applications

Social implications
– Approaches to improving the Quality of Life of people with disabilities through an extended use of assistive technologies will be enhanced by the increased range of devices available and by their performance.

Originality/value
– To the best of the authors’ knowledge, this is the first review of wearable devices that has focused on the needs of people who have rehabilitation and/or social care needs. Its value lies in encouraging manufacturers and designers to use wearable approaches to solving some of the problems facing vulnerable people.
The influence of CEO values and leadership on middle manager exchange behaviors
Authors: Liden Robert , Fu Pingping , Liu Jun , Song Lynda 
Published: March 2016

Purpose– The purpose of this paper is to examine the extent to which chief executive officer (CEO) transactional and transformational leader behaviors as well as CEO self-enhancing versus self-transcendent values permeate through the organization to influence middle-level managers.Design/methodology/approach– Using a multi-level longitudinal design, the authors collected self-reported value data from 32 CEOs and 119 top management team (TMT) members rated their CEOs on transactional and transformational leader behaviors at Time 1; 18 months later, TMTs rated the in-role behaviors and organizational citizenship behaviors (OCBs) of 331 mid-level managers. Also, at Time 2, mid-level managers evaluated their relationship with the organization in terms of economic and social exchange. HLM was used to analyze the data.Findings– The authors found the positive relationship between transactional CEO leader behaviors and mid-level manager in-role behaviors to be enhanced when CEOs hold self-transcendent values, whereas this relationship was weakened by CEO self-enhancing values. Similarly, the relationship between CEO transformational leader behaviors and mid-level manager OCBs was found to be strengthened when leaders espoused self-transcendent values. Finally, the authors found that economic exchange mediated the relationship between the transactional leadership * self-enhancing values interaction term and mid-level manager in-role behaviors. Similarly, social exchange mediated the relationship between the transformational leadership * self-transcendent values interaction term and mid-level manager OCBs.Originality/value– Leadership/OB.
Five‐year follow‐up of cognitive impairment in older adults with bipolar disorder
Authors: Schouws Sigfried NTM , Comijs Hannie C , Dols Annemieke , Beekman Aartjan TF , Stek Max L 
Published: March 2016

ObjectiveTo date, cognitive impairment has been thought to be an integral part of bipolar disorder. In clinical staging models, cognitive impairment is one of the hallmarks to define the clinical stage and it plays an important role in identifying the risk factors for progression to later stages of the illness. It is important to examine neurocognitive performance over longer periods to test the hypothesis of neuroprogression of bipolar disorder.MethodsA comprehensive neuropsychological test battery was applied at baseline and five years later to 56 euthymic older outpatients with bipolar disorder (mean age = 68.35 years, range: 60–90 years) and to a demographically matched sample of 44 healthy subjects. A group‐by‐time repeated measures multivariate analysis of variance was performed to measure changes over time for the two groups. The impact of baseline illness characteristics on the intra‐individual change in neurocognitive performance within the bipolar disorder group was studied by using logistic regression analysis.ResultsAt baseline and at follow‐up, patients with bipolar disorder performed worse on all neurocognitive measures compared to the matched healthy subjects. However, there was no significant group‐by‐time interaction between the patients with bipolar disorder and the comparison group.ConclusionsAlthough older patients with bipolar disorder had worse cognitive function than healthy subjects, they did not have greater cognitive decline over a five‐year period. The change in acquired cognitive impairment of patients with bipolar disorder might parallel the cognitive development as seen in normal aging.