bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzo[1,2‐b:4,5‐b′]Dithiophene–6,7‐Difluoroquinoxaline Small Molecule Donors with >8% BHJ Solar Cell Efficiency
Authors: Liang Ru‐Ze , Wang Kai , Wolf Jannic , Babics Maxime , Wucher Philipp , Thehaiban Mohammad K. Al , Beaujuge Pierre M. 
Published: July 2017

AbstractSolution‐processable small molecule (SM) donors are promising alternatives to their polymer counterparts in bulk‐heterojunction (BHJ) solar cells. While SM donors with favorable spectral absorption, self‐assembly patterns, optimum thin‐film morphologies, and high carrier mobilities in optimized donor–acceptor blends are required to further BHJ device efficiencies, material structure governs each one of those attributes. As a result, the rational design of SM donors with gradually improved BHJ solar cell efficiencies must concurrently address: (i) bandgap tuning and optimization of spectral absorption (inherent to the SM main chain) and (ii) pendant‐group substitution promoting structural order and mediating morphological effects. In this paper, the rational pendant‐group substitution in benzo[1,2‐b:4,5‐b′]dithiophene–6,7‐difluoroquinoxaline SMs is shown to be an effective approach to narrowing the optical gap (Eopt) of the SM donors (SM1 and SM2), without altering their propensity to order and form favorable thin‐film BHJ morphologies with PC71BM. Systematic device examinations show that power conversion efficiencies >8% and open‐circuit voltages (VOC) nearing 1 V can be achieved with the narrow‐gap SM donor analog (SM2, Eopt = 1.6 eV) and that charge transport in optimized BHJ solar cells proceeds with minimal, nearly trap‐free recombination. Detailed device simulations, light intensity dependence, and transient photocurrent analyses emphasize how carrier recombination impacts BHJ device performance upon optimization of active layer thickness and morphology.
Dimensional Engineering of a Graded 3D–2D Halide Perovskite Interface Enables Ultrahigh Voc Enhanced Stability in the p‐i‐n Photovoltaics
Authors: Bai Yang , Xiao Shuang , Hu Chen , Zhang Teng , Meng Xiangyue , Lin He , Yang Yinglong , Yang Shihe 
Published: July 2017

Abstract2D halide perovskite materials have shown great advantages in terms of stability when applied in a photovoltaic device. However, the impediment of charge transport within the layered structure drags down the device performance. Here for the first time, a 3D–2D (MAPbI3‐PEA2Pb2I4) graded perovskite interface is demonstrated with synergistic advantages. In addition to the significantly improved ambient stability, this graded combination modifies the interface energy level in such a way that reduces interface charge recombination, leading to an ultrahigh Voc at 1.17 V, a record for NiO‐based p‐i‐n photovoltaic devices. Moreover, benefiting from the graded structure induced continuously upshifts energy level, the photovoltaic device attains a high Jsc of 21.80 mA cm−2 and a high fill factor of 0.78, resulting in an overall power conversion efficiency (PCE) of 19.89%. More importantly, it is showed that such a graded interface structure also suppresses ion migration in the device, accounting for its significantly enhanced thermal stability.
Supramolecular Nanotubules as a Catalytic Regulator for Palladium Cations: Applications in Selective Catalysis
Authors: Wu Shanshan , Li Yongguang , Xie Siying , Ma Cong , Lim Joonwon , Zhao Jiong , Kim Dae Seok , Yang Minyong , Yoon Doong Ki , Lee Myongsoo , Kim Sang Ouk , Huang Zhegang 
Published: July 2017

AbstractDespite the recent development of highly efficient and stable metal catalysts, conferral of regulatory characteristics to the catalytic reaction in heterogeneous systems remains a challenge. Novel supramolecular nanotubules were prepared by alternative stacking from trimeric macrocycles, which was found to be able to coordinate with Pd cations. The Pd complexes exhibited a high catalytic performance for C−C coupling reaction. Notably, the tubular catalyst was observed to be controlled by supramolecular reversible assembly and showed superior heterogeneous catalytic activity, which was maintained for a number of cycles or reuse under an aerobic environment. Furthermore, the supramolecular catalyst showed unprecedented selectivity for the multifunctional coupling reaction and was able to serve as a new constructor of asymmetrical compounds.
Evidence‐based policy choices for efficient and equitable cervical cancer screening programs in low‐resource settings
Authors: Campos Nicole G. , Tsu Vivien , Jeronimo Jose , Mvundura Mercy , Kim Jane J. 
Published: July 2017

AbstractWomen in developing countries disproportionately bear the burden of cervical cancer. The availability of prophylactic vaccines against human papillomavirus (HPV) types 16 and 18, which cause approximately 70% of cervical cancers, provides reason for optimism as roll‐out begins with support from Gavi, the Vaccine Alliance. However, for the hundreds of millions of women beyond the target age for HPV vaccination, cervical cancer screening to detect and treat precancerous lesions remains the only form of prevention. Here we describe the challenges that confront screening programs in low‐resource settings, including (1) optimizing screening test effectiveness; (2) achieving high screening coverage of the target population; and (3) managing screen‐positive women. For each of these challenges, we summarize the tradeoffs between resource utilization and programmatic attributes. We then highlight opportunities for efficient and equitable programming, with supporting evidence from recent mathematical modeling analyses informed by data from the PATH demonstration projects in India, Nicaragua, and Uganda.
Cooperation of HIF‐ and NCAM‐mediated mechanisms in cell viability of hippocampal cultures after oxygen–glucose deprivation
Authors: Lushnikova Iryna , Nikandrova Yelyzaveta , Skibo Galyna 
Published: July 2017

AbstractNeurodegenerative diseases of different genesis are the result of cellular damages including those caused by oxygen and glucose deficit. Neuronal survival or death in brain pathologies depends on a variety of interrelated molecular mechanisms. A key role in modulation of neuron viability belongs to HIF (hypoxia‐inducible factor) and NCAM (neural cell adhesion molecules) signaling pathways. In this work, we used organotypic and dissociated hippocampal cultures to analyze cell viability and HIF‐1α immunopositive (HIF‐1α+) signal after 30 min oxygen–glucose deprivation (OGD) followed by 24 h of reoxygenation in the presence of FGL (synthetic NCAM‐derived mimetic peptide). According to LDH‐ and MTS‐assay of cell viability, FGL showed a neuroprotective effect, which was attributed to the association with FGFR. We showed that these effects correlated with changes of the HIF‐1α+ level suggesting the communications of HIF and NCAM signaling pathways. These data extend our knowledge of neurodegeneration mechanisms and open additional potential for the development of neuroprotection strategies.
Cardiac transplant vasculopathy
Authors: Tobis Jonathan M. 
Published: July 2017

Key Points

Transplant vasculopathy is a form of slowly progressive rejection.
The interventional cardiologist plays an important role in maintaining survival of this precious commodity by performing PCI.
Everolimus drug eluting stents are highly effective and have relatively low occurrence of in‐stent restenosis, but transplant vasculopathy continues to progress in a diffuse pattern.
Current approaches to retroperitoneal hemorrhage: Too little, too late
Authors: Safian Robert D. 
Published: July 2017

Key Points

Retroperitoneal hemorrhage (RPH) arises in < 0.5% of patients undergoing percutaneous intervention, but is associated with high risks of morbidity and mortality.
More than 50% of medical malpractice claims against interventional cardiologists are related to death and hemorrhage from vascular injury; delays in diagnosis and treatment are common.
The current approach to RPH is characterized by “too little” to diagnose and “too late” to manage patients in extremis. Immediate CTA allows rapid diagnosis and triage to appropriate endovascular therapy, without delay.
Left atrial pressure and predictors of survival after percutaneous mitral paravalvular leak closure
Authors: Maor Elad , Raphael Claire E. , Panaich Sidakpal S. , Alkhouli Mohamad , Cabalka Allison , Hagler Donald J. , Pollak Peter M. , Reeder Guy S. , Eleid Mackram F. , Rihal Charanjit S. 
Published: July 2017

AbstractBackgroundData on the clinical utility of left atrial (LA) hemodynamic monitoring during percutaneous mitral interventions are limited.ObjectivesTo evaluate the association between intraprocedural LA pressures during percutaneous mitral paravalvular leak (PVL) closure and long term survival.MethodsPatients who underwent mitral PVL repair with invasive LA pressure monitoring were divided at baseline to three tertiles based on their mean final LA pressure (<25%; 25‐30%; >30% of mean systolic blood pressure). Primary outcome was all‐cause mortality.Results134 patients (mean age 68 ± 12 years) were studied. Over 3 year mean follow‐up, 81 (38%) patients died. The cumulative probability of death at 3 years was significantly higher among patients in the highest LA pressure tertile (56 ± 8% vs. 28 ± 5%, log rank P < 0.001). More than mild residual mitral regurgitation (MR) by transesophageal echocardiography (TEE) was associated with a 2.5‐fold increased risk of death and patients in the highest LA pressure tertile had 2.2‐fold higher mortality (P < 0.001 and = 0.003 respectively). After adjustment for residual MR by TEE, each 10% acute procedural reduction in LA pressures was associated with a significant 9% reduced risk of death (P = 0.023). Multivariate Cox regression with adjustment for multiple predictors of death showed that patients in lower LA pressure tertiles had 59% lower mortality (P = 0.003).ConclusionLower LA pressure following mitral PVL closure is an independent predictor of improved survival, even after adjustment for residual MR. LA pressure monitoring may be a useful tool for procedural guidance during mitral PVL closure.
Development and validation of a risk model for long‐term mortality after percutaneous coronary intervention: The IDEA‐BIO Study
Authors: van Boven Nick , van Domburg Ron T. , Kardys Isabella , Umans Victor A. , Akkerhuis K. Martijn , Lenzen Mattie J. , Valgimigli Marco , Daemen Joost , Zijlstra Felix , Boersma Eric , van Geuns Robert‐Jan 
Published: July 2017

AbstractObjectivesWe aimed to develop a model to predict long‐term mortality after percutaneous coronary intervention (PCI), to aid in selecting patients with sufficient life expectancy to benefit from bioabsorbable scaffolds.BackgroundClinical trials are currently designed to demonstrate superiority of bioabsorbable scaffolds over metal devices up to 5 years after implantation.MethodsFrom 2000 to 2011, 19.532 consecutive patients underwent PCI in a tertiary referral hospital. Patients were randomly (2:1) divided into a training (N = 13,090) and validation (N = 6,442) set. Cox regression was used to identify determinants of long‐term mortality in the training set and used to develop a risk model. Model performance was studied in the training and validation dataset.ResultsMedian age was 63 years (IQR 54–72) and 72% were men. Median follow‐up was 3.6 years (interquartile range [IQR] 2.4‐6.8). The ratio elective vs. non‐elective PCIs was 42/58. During 88,620 patient‐years of follow‐up, 3,156 deaths occurred, implying an incidence rate of 35.6 per 1,000. Estimated 5‐year mortality was 12.9%.Regression analysis revealed age, body mass index, diabetes mellitus, renal insufficiency, prior myocardial infarction, PCI indication, lesion location, number of diseased vessels and cardiogenic shock at presentation as determinants of mortality. The long‐term risk model showed good discrimination in the training and validation sets (c‐indices 0.76 and 0.74), whereas calibration was appropriate.ConclusionsA simple risk model, containing 9 baseline clinical and angiographic variables effectively predicts long‐term mortality after PCI and may possibly be used to select suitable patients for bioabsorbable scaffolds.
Three‐ and 6‐month optical coherence tomographic surveillance following percutaneous coronary intervention with the Angiolite® drug‐eluting stent: The ANCHOR study
Authors: Puri Rishi , Otaegui Imanol , Sabaté Manel , Serra‐Peñaranda Antonio , Puigfel Marti , Perez de Prado Armando , Nombela‐Franco Luis , de la Torre Hernandez Jose M. , Ortas Nadal Rosario , Iniguez‐Romo Andres , Jiménez Gustavo , Fernandez‐Vazquez Felipe , Cuellas‐Ramon Carlos , Gonzalo Nieves , Alfonso Jiménez Diaz Victor , Duocastella Lluis , Molina Maria , Amoros Marc , Perez Isabel , Barria Perez Alberto , Pelletier Beaumont Emilie , Nicholls Stephen J. , Garcia del Blanco Bruno , Rodés‐Cabau Josep 
Published: July 2017

AbstractBackgroundPre‐clinical results of a novel open‐cell, thin strut, durable polymer, laser cut cobalt chromium sirolimus‐eluting stent (Angiolite) were promising. Using quantitative optical coherence tomographic (OCT) analyses, we explored the healing characteristics of the Angiolite DES system at 3‐ and 6‐months post implantation.MethodsA total of 103 patients with de novo coronary lesions underwent percutaneous coronary intervention with the Angiolite DES and were randomized 1:3 into two cohorts for angiographic and OCT follow‐up, with 28 and 70 patients returning for 3‐ or 6‐month post‐PCI surveillance, respectively. The primary endpoints were the 6‐month rates of OCT‐derived neointimal proliferation, strut coverage and incomplete strut apposition (ISA), whilst the secondary endpoints were 3‐month OCT‐derived measures of strut coverage and ISA, as well as 6‐month quantitative coronary angiographic‐derived measures [late lumen loss (LLL), binary restenosis].ResultsThe Angiolite stent was successfully implanted in all patients, without periprocedural complications. At 3‐ and 6‐months follow‐up, OCT strut coverage was evident in 86.3% and 83.3% of struts, mean neointimal thickness was 73.7 ± 46.5 μm and 73.9 ± 54.3 μm, mean neo‐intimal area obstruction of 5.8% ±10.3% and 4.4% ± 11.3%, and ISA rates were 1.3% ± 7.3% and 1.1% ± 6.2%, respectively. In‐stent LLL at 6 months was 0.07 ± 0.37 mm, with a binary in‐stent angiographic restenosis rate of 0% without any stent thrombosis, myocardial infarction or cardiovascular death, with 1 patient undergoing ischemia‐driven target‐lesion revascularization.ConclusionsAt 6 months, the Angiolite DES was safe with high rates of strut coverage, modest degrees of neointimal hyperplasia and very low rates of strut malapposition. These data coupled with the absence of in‐stent binary restenosis and a very low 6‐month in‐stent LLL point towards an efficacious DES. Future studies are required to evaluate its efficacy in broader lesion subsets with longer follow‐up.
Primary cardiac intimal sarcoma masquerading as mitral stenosis
Authors: Spartalis Michael , Tzatzaki Eleni , Spartalis Eleftherios , Moris Demetrios , Athanasiou Antonios , Kyrzopoulos Stamatios , Tsiapras Dimitrios , Voudris Vassilis 
Published: July 2017

Key Clinical MessageIntimal sarcomas are a very rare medical entity and usually arise from the pulmonary artery or the thoracic aorta. Sarcomas should be considered in the differential diagnosis in patients with suspected mitral valve disease. Echocardiography should be performed as early as possible to establish a prompt diagnosis and management.
Solubility of CO2 in water and NaCl solution in equilibrium with hydrate. Part II: Model calculation
Authors: Sun Qiang , Tian Huan , Guo Xuqiang , Liu Aixian , Yang Lanying 
Published: July 2017

AbstractIn this work, a calculation model of CO2 solubility in equilibrium with hydrate was developed on the basis of the Patel‐Teja equation of state and Chen‐Guo hydrate model. The solubility of CO2 in water and NaCl solution in equilibrium with hydrate were calculated respectively under the temperature window of 273.95 K to 282.55 K and the pressure window of 2.0 MPa to 8.0 MPa. The comparisons between the calculated and experimental values show that the average absolute deviation percentages (AADP) are 2.12 % for the CO2/H2O system and 2.31 % for the CO2/NaCl/H2O system, respectively. It demonstrates that the model proposed in this work could well predict the solubility of CO2 in NaCl solution in equilibrium with hydrate.
Colorectal cancer screening at US community health centers: Examination of sociodemographic disparities and association with patient‐provider communication
Authors: Lin Sue C. , McKinley Duane , Sripipatana Alek , Makaroff Laura 
Published: July 2017

BACKGROUNDColorectal cancer (CRC) screening rates are low among underserved populations. High‐quality patient‐physician communication potentially influences patients' willingness to undergo CRC screening. Community health centers (HCs) provide comprehensive primary health care to underserved populations. This study's objectives were to ascertain national CRC screening rates and to explore the relations between sociodemographic characteristics and patient‐provider communication on the receipt of CRC screening among HC patients.METHODSUsing 2014 Health Center Patient Survey data, bivariate and multivariate analyses examined the association of sociodemographic variables (sex, race/ethnicity, age, geography, preferred language, household income, insurance, and employment status) and patient‐provider communication with the receipt of CRC screening.RESULTSPatients between the ages of 65 and 75 years (adjusted odds ratio [aOR], 2.49; 95% confidence interval [CI], 1.33‐4.64) and patients not in the labor force (aOR, 2.32; 95% CI, 1.37‐3.94) had higher odds of receiving CRC screening, whereas patients who were uninsured (aOR, 0.33; 95% CI, 0.18‐0.61) and patients who were non–English‐speaking (aOR, 0.42; 95% CI, 0.18‐0.99) had lower odds. Patient‐provider communication was not associated with the receipt of CRC screening.CONCLUSIONSThe CRC screening rate for HC patients was 57.9%, whereas the rate was 65.1% according to the 2012 Behavioral Risk Factor Surveillance System and 58.2% according to the 2013 National Health Interview Survey. The high ratings of patient‐provider communication, regardless of the screening status, suggest strides toward a patient‐centered medical home practice transformation that will assist in a positive patient experience. Addressing the lack of insurance, making culturally and linguistically appropriate patient education materials available, and training clinicians and care teams in cultural competency are critical for increasing future CRC screening rates. Cancer 2017;123:4185–4192. © 2017 American Cancer Society.
Stereotactic body radiotherapy for unresected pancreatic cancer: A nationwide review
Authors: de Geus Susanna W. L. , Eskander Mariam F. , Kasumova Gyulnara G. , Ng Sing Chau , Kent Tara S. , Mancias Joseph D. , Callery Mark P. , Mahadevan Anand , Tseng Jennifer F. 
Published: July 2017

BACKGROUNDThe role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer.METHODSThe National Cancer Data Base was queried for unresected patients who received chemotherapy for nonmetastatic pancreatic adenocarcinoma between 2004 and 2012. Four treatment groups were identified: chemotherapy alone, chemotherapy combined with external‐beam radiotherapy (EBRT), chemotherapy combined with intensity‐modulated radiotherapy (IMRT), and chemotherapy combined with SBRT. Propensity score models predicting the odds of receiving SBRT were created to control for potential selection bias, and patients were matched by propensity scores. The survival analysis was performed with the Kaplan‐Meier method.RESULTSA total of 14,331 patients met the inclusion criteria. Chemotherapy alone was delivered to 5464 patients (38.1%); 6418 (44.8%), 322 (2.3%), and 2127 (14.8%) received chemotherapy along with EBRT, IMRT, and SBRT, respectively. The unadjusted median survival before matching was 9.9, 10.9, 12.0, and 13.9 months for patients treated with chemotherapy, EBRT, IMRT, and SBRT, respectively. In separate matched analyses, SBRT remained superior to chemotherapy alone (log‐rank P < .0001) and EBRT (log‐rank P = .0180). After matching, survival did not differ between patients receiving IMRT and patients receiving SBRT (log‐rank P = .0492).CONCLUSIONSSBRT is associated with a significantly better outcome than chemotherapy alone or in conjunction with traditional EBRT. These results support the idea that SBRT is a promising treatment approach for patients with unresected pancreatic cancer. Cancer 2017;123:4158–4167. © 2017 American Cancer Society.
Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin‐based chemotherapy in patients with metastatic colorectal cancer
Authors: Okazaki Satoshi , Schirripa Marta , Loupakis Fotios , Cao Shu , Zhang Wu , Yang Dongyun , Ning Yan , Berger Martin D. , Miyamoto Yuji , Suenaga Mitsukuni , Iqubal Syma , Barzi Afsaneh , Cremolini Chiara , Falcone Alfredo , Battaglin Francesca , Salvatore Lisa , Borelli Beatrice , Helentjaris Timothy G. , Lenz Heinz‐Josef 
Published: July 2017

BACKGROUNDThe hypermethylated in cancer 1/sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin‐induced damage‐repair system. On the basis of prior evidence that the variable number of tandem repeat (VNTR) sequence located near the promoter lesion of HIC1 is associated with HIC1 gene expression, the authors tested the hypothesis that this VNTR is associated with clinical outcome in patients with metastatic colorectal cancer who receive oxaliplatin‐based chemotherapy.METHODSFour independent cohorts were tested. Patients who received oxaliplatin‐based chemotherapy served as the training cohort (n = 218), and those who received treatment without oxaliplatin served as the control cohort (n = 215). Two cohorts of patients who received oxaliplatin‐based chemotherapy were used for validation studies (n = 176 and n = 73). The VNTR sequence near HIC1 was analyzed by polymerase chain reaction analysis and gel electrophoresis and was tested for associations with the response rate, progression‐free survival, and overall survival.RESULTSIn the training cohort, patients who harbored at least 5 tandem repeats (TRs) in both alleles had a significantly shorter PFS compared with those who had fewer than 4 TRs in at least 1 allele (9.5 vs 11.6 months; hazard ratio, 1.93; P = .012), and these findings remained statistically significant after multivariate analysis (hazard ratio, 2.00; 95% confidence interval, 1.13‐3.54; P = .018). This preliminary association was confirmed in the validation cohort, and patients who had at least 5 TRs in both alleles had a worse PFS compared with the other cohort (7.9 vs 9.8 months; hazard ratio, 1.85; P = .044).CONCLUSIONSThe current findings suggest that the VNTR sequence near HIC1 could be a predictive marker for oxaliplatin‐based chemotherapy in patients with metastatic colorectal cancer. Cancer 2017;123:4506‐14. © 2017 American Cancer Society.