bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging technological developments to address pest resistance in Bt cotton
Authors: Nagaraj Selvarani , Rajasekaran Ravikesavan , Palaniappan Jayamani , Rangasamy Selvakumar , Narayanasamy Chitra , Narayanan Manikanda Booapathi 
Published: September 2024

AbstractCotton plays a crucial role in shaping Indian economy and rural livelihoods. The cotton crop is prone to numerous insect pests, necessitating insecticidal application, which increases production costs. The advent of the expression of Bacillus thuringiensis (Bt) insecticidal protein in cotton has significantly reduced the burden of pest without compromising environmental or human health. After the introduction of transgenic cotton, the cultivated area expanded to 22 million hectares, with a 64% increase in adoption by farmers worldwide. Currently, Bt cotton accounts for 93% of the cultivated cotton area in India. However, extensive use of Bt cotton has accelerated resistance development in pests like the pink bollworm. Furthermore, the overreliance on Bt cotton has reduced the use of broad-spectrum pesticides, favouring the emergence of secondary pests with significant challenges. This emphasizes the urgent necessity for developing novel pest management strategies. The high-dose and refuge strategy was initially effective for managing pest resistance in Bt cotton, but its implementation in India faced challenges due to misunderstandings about the use of non-Bt refuge crops. Although gene pyramiding was introduced as a solution, combining mono toxin also led to instances of cross-resistance. Therefore, there is a need for further exploration of biotechnological approaches to manage insect resistance in Bt cotton. Advanced biotechnological strategies, such as sterile insect release, RNA interference (RNAi)-mediated gene silencing, stacking Bt with RNAi, and genome editing using clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR-Cas), offer promising tools for identifying and managing resistance genes in insects. Additionally, CRISPR-mediated gene drives and the development of novel biopesticides present potential avenues for effective pest management in cotton cultivation. These innovative approaches could significantly enhance the sustainability and efficacy of pest resistance management in Bt cotton.
Pinning synchronization of a complex network: Nodes, edges and higher-order edges
Authors: Jiang QiShu , Zhou Jin , Li Bo , Liu HaoRan , Lu Jun-an 
Published: September 2024

Abstract
In recent years, the interdisciplinary study of complex networks has become increasingly important in fields ranging from biology and physics to sociology and mathematics. This paper focuses on pinning control, an approach essential for achieving coordinated behavior in dynamic networks. We explore recent advancements in pinning control strategies, explaining theoretical frameworks and simulation techniques. Additionally, we discuss the significance of certain structures within networks across different orders. Finally, we conclude with a summary of key insights and propose our outlook on future research.
Does Bank Monitoring Reduce Corporate Misreporting? Evidence from Foreign Bank Entry in China
Authors: Li Minwen , Makaew Tanakorn , Winton Andrew 
Published: September 2024

We propose a model of bank monitoring and borrower financial misreporting. Using the staggered liberalization of the banking sector in China as a natural experiment, we find that, consistent with the model’s prediction, entry by more efficient foreign banks reduces corporate misreporting fraud. Fraud reduction is greatest among borrowers of foreign banks, but fraud also drops among borrowers of domestic banks, suggesting a spillover effect. As predicted by the model, fraud reduction is greatest for borrowers with higher levels of fixed assets or lower levels of current assets. Our evidence suggests that improved bank monitoring reduces financial misreporting. This paper was accepted by Tomasz Piskorski, finance. Funding: M. Li acknowledges support from the National Science Foundation of China [Project 71402078] and the Social Science Foundation of Tsinghua University [Project 2013WKZD004]. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2022.02414 .
Hematological picture of pediatric Sudanese patients with visceral leishmaniasis and prediction of leishmania donovani parasite load
Authors: Elnoor Zeinab Ibrahim Ahmed , Abdelmajeed Omaima , Mustafa Alamin , Gasim Thuraya , Musa Shima Algam Mohamed , Abdelmoneim Abdelrahman Hamza , Omer Islamia Ibrahim Ahmed , Fadl Hiba Awadelkareem Osman 
Published: September 2024

BACKGROUND
Visceral leishmaniasis (VL) is a systemic protozoan infection caused by Leishmania donovani (L. donovani ) and transmitted by sand flies, causing macrophage invasion in the liver, spleen, and bone marrow. Diagnosis of VL is currently based on clinical signs, symptoms, and specific in-vitro markers and bone marrow investigations. However, VL's specific hematological and bone marrow manifestation in Sudanese pediatric patients is not well studied.
AIM
To examine the blood and bone marrow characteristics in pediatric patients from Sudan who have VL.
METHODS
This is a retrospective hospital-based study with a sample of 107 consecutive Sudanese pediatric patients. The data focused on hematological and bone marrow results. We included only the completed records of the pediatric patients with VL in the Tropical Disease Teaching Hospital in Khartoum, Sudan from the period of 2016 to 2020.
RESULTS
The majority of pediatric patients included in this study are below 5-years-old (n = 59, 55.2%). Moreover, anemia, thrombocytopenia, and leukopenia were among the prevalent characteristics in the population under study. To further analyze the data, we developed a machine learning model using boosted forest algorithms to predict L. donovani parasites load, with a mean accuracy of 0.88 for the training dataset and an accuracy of 0.46, 0.50, and 0.74 for mild, moderate, and severe L. donovani parasite load in the validation dataset.
CONCLUSION
This study shows that the most common bone marrow change among Sudanese VL children was increased chronic inflammatory cells (n = 88, 82.2%) with present macrophage hemophagocytes (n = 103, 96.3%). While anemia and thrombocytopenia were the most common hematological changes. These results will hopefully lead to an early diagnosis and hence better management for Sudanese pediatric patients with suspected VL.
Deep neural networks integrating genomics and histopathological images for predicting stages and survival time-to-event in colon cancer
Authors: Ogundipe Olalekan , Kurt Zeyneb , Woo Wai Lok 
Published: September 2024

Motivation
There exists an unexplained diverse variation within the predefined colon cancer stages using only features from either genomics or histopathological whole slide images as prognostic factors. Unraveling this variation will bring about improved staging and treatment outcomes. Hence, motivated by the advancement of Deep Neural Network (DNN) libraries and complementary factors within some genomics datasets, we aggregate atypia patterns in histopathological images with diverse carcinogenic expression from mRNA, miRNA and DNA methylation as an integrative input source into a deep neural network for colon cancer stages classification, and samples stratification into low or high-risk survival groups.

Results
The genomics-only and integrated input features return Area Under Curve–Receiver Operating Characteristic curve (AUC-ROC) of 0.97 compared with AUC-ROC of 0.78 obtained when only image features are used for the stage’s classification. A further analysis of prediction accuracy using the confusion matrix shows that the integrated features have a weakly improved accuracy of 0.08% more than the accuracy obtained with genomics features. Also, the extracted features were used to split the patients into low or high-risk survival groups. Among the 2,700 fused features, 1,836 (68%) features showed statistically significant survival probability differences in aggregating samples into either low or high between the two risk survival groups.
Availability and Implementation: https://github.com/Ogundipe-L/EDCNN
Self-stigmatization and treatment preferences: Measuring the impact of treatment labels on choices for depression medications
Authors: Gonzalez Sepulveda Juan Marcos , Townsend Michael , Waters Heidi C. , Brubaker Maalak , Wallace Matthew , Johnson Reed 
Published: September 2024

Objective
To collect evidence on the possibility that patients with depression experience self-stigmatization based on label information for medications.

Methods
We developed a discrete-choice experiment (DCE) survey instrument that asked respondents to make choices between hypothetical treatments for major depressive disorder (MDD). We also included treatment type (antidepressants versus antipsychotics) and approved indications for the medication. The choice questions mimicked the information presented in product inserts and required systematic tradeoffs between treatment efficacy, treatment type, and indication. We calculated how many patients were willing to forgo efficacy to avoid treatments with information associated with self-stigmatization, and how much efficacy they were willing to forgo. We also evaluated the impact of contextualizing the treatment information to reduce self-stigmatization by randomizing respondents who received additional context.

Results
A total of 501 patients with MDD were recruited to complete the DCE survey. Respondents had well-defined preferences for treatment outcomes. Over 60% (63.4%) of respondents were found to be significantly affected by treatment indication. These respondents were willing to forgo about 2.5 percentage points in the chance of treatment efficacy to avoid treatments indicated for schizophrenia. We also find that some level of contextualization of the treatment details could help reduce the negative impact of treatment type and indications.

Conclusions
Product-label treatment indication can potentially lead to patient self-stigmatization as shown by patients’ avoidance of treatments that are also used to treat schizophrenia. While the effect appears to be relatively small, results suggests that the issue is likely pervasive.
Singing the Psyche: Uniting Thought and Feeling through the Voice: Voice Movement Therapy in Practice, Anne M. Brownell, Deirdre A. Brownell and Gina H. Mulder (eds) (2023)
Authors: Rees Hannah 
Published: September 2024

Review of: Singing the Psyche: Uniting Thought and Feeling through the Voice: Voice Movement Therapy in Practice, Anne M. Brownell, Deirdre A. Brownell and Gina H. Mulder (eds) (2023)
Springfield, IL: Charles C Thomas Publisher, 320 pp.,
ISBN 978-0-39809-424-9, p/bk, $28.95
Development and Validation of a Mobile Application for Early Childhood Nutrition Monitoring: A Multisensor-Based Non-Contact Anthropometric System
Authors: Yafie Evania , Pramono  , Sutama I Wayan , Samawi Ahmad , Khairuddin Khairul Farhah Binti , Asyhari Rahayu 
Published: September 2024

The issue of early childhood nutrition in Indonesia, including the high prevalence of stunting, is of critical importance as it can permanently impair children's physical growth and cognitive development. Parents frequently encounter challenges in accurately and consistently monitoring their children's nutritional status, which impedes the early detection of nutritional issues. This study introduces the Multisensor-Based Non-Contact Anthropometric System (MB-NCAS), a mobile application developed to monitor nutritional status and detect stunting in early childhood. The research encompassed five phases using a modified ADDIE model: Analysis, Design, Development, Implementation, and Evaluation. In the Analysis phase, parent questionnaires identified critical nutritional needs and challenges related to stunting. The Design phase focused on setting clear objectives and developing educational content for the app. The Development phase saw the app's creation, which experts in content accuracy, media design, and instructional strategies subsequently validated. During the Implementation phase, the app was tested with parents in Malang City, who participated in pretest and posttest evaluations to assess the app's practicality and effectiveness. The results indicated significant improvements in parental knowledge and skills in monitoring child nutrition and stunting, with expert validation scores averaging 92.6% for media design, 86.25% for material content, and 87.28% for instructional design. The MB-NCAS app is a valid, reliable, and practical tool for early childhood nutrition monitoring. However, challenges such as limited technology access in certain areas may hinder its broader application. Future research should explore the app's effectiveness in diverse settings and focus on improving technology accessibility to enhance its impact on public health.
Introduction: Touching Troy
Authors: Johnston Andrew James , Keller Wolfram R. , Ravenhall Henry 
Published: September 2024

Abstract
This introduction aims to briefly sketch the theoretical framework for the articles assembled in this special issue on touch within the transmission of the Troy story in western Europe. Starting with the analysis of an important scene involving reading and manuscript culture in Geoffrey Chaucer’s Troilus and Criseyde, this introduction provides a context for medieval instances of touching within contemporary thinking about materiality and relationality and within the transmission of the Troy story in late medieval and early modern Europe.
新漢語水平考試應試輔導教材對比分析: 以中韓兩國 HSK 三級為例
Authors: 容玥 杜 , 玟荣 河 
Published: September 2024

摘要
本文探討新漢語水平考試應試教材之分析, 選取中韓兩國出版之新 HSK3 級應試輔導教材《HSK 標準教程 3》與《使用一本書通過新 HSK3 級》進行對比分析, 這兩套教材分別為中韓兩國具影響力的華語教材。本研究根據新 HSK 考試大綱, 針對兩套教材, 從整體編排、詞彙和語法、課文及練習等方面進行分析, 並且探討韓國學習者的語言背景、選擇華語教材的偏好、應試教材的影響力等。選取 HSK 三級這個等級作為探究主題是由於 HSK 三級往往為華語學習者學習歷程的轉捩點, 有些人會繼續學習通過四級, 但有些人則不再繼續, 因此 HSK 三級應試教材在華語學習階段中扮演了重要的角色。本文透過兩套教材的比較以及分析問卷調查的結果, 從中發現二者的個性與共性, 希冀能為韓國國內的華語學習者提供選用教材的參考指標, 並從教材開發與編寫的角度提出以下建議: 一、增加漢字分析的內容, 比如易混淆字、繁簡字等; 二、調整教材編寫的整體結構和版式設計; 三、增加與新 HSK 真題有關的模擬題, 以利於學習者掌握漢語水準考試的形式; 四、增加文本閱讀的詞語切分、句子斷句等內容, 增強學習者對華語詞彙的知識; 五、針對性地在華語教材中專門設置類似「提醒」板塊或環節, 增加華語和韓語之語言特徵對比的內容。本研究旨在幫助華語學習者增進應試技巧, 同時能在實際使用華語時能對自己的偏誤予以改進, 避免犯一些特有的「韓式」發音或語法錯誤, 進而提高華語交際能力。
Imagining an Alternative Future: Children’s Bodies in Wonder Boy (1988), Magic Watch (1990), and Mad Rabbit (1997)
Authors: Liang Shuang 
Published: September 2024

Abstract
Since China launched its reform and opening-up campaign, the country experienced significant economic growth and infrastructure expansion, which helped spur the release of numerous science fiction works. Among these works, Zhang Zhilu’s three children’s sf films presented an alternative future for Chinese children and teenagers. This essay contends that while these films portray children as integral to infrastructure and the construction of a market economy network, they opt for natural and playful growth driven by a longing for freedom and emotional connection, and by doing so they circumvent the predetermined and goal-oriented trajectory of social development.
How individuals cope with anger- and sadness-induced narrative misinformation on social media: roles of transportation and correction
Authors: Zhao Xinyan , Shaw Jessica , Ma Zexin 
Published: September 2024

Abstract

Purpose
The spread of health conspiracies and misinformation online threatens public health as most Americans choose to acquire health information online. This study examines how discrete emotions like anger and sadness influence individuals’ responses to narrative-based health misinformation, proposing a theoretical model of narrative misinformation coping and exploring the mechanisms through which these emotions affect risk perception and misinformation coping.

Design/methodology/approach
Through a 2 (Misinformation type: narrative vs. non-narrative) × 2 (Issue: climate change vs. fentanyl overdose) × 2 (Correction: present vs. absent) online experiment (N = 401), our results underscore the importance of both risk coping and misinformation coping in individuals’ responses to emotional narrative misinformation, along with the role of narrative transportation in intensifying felt emotions and facilitating both types of coping.

Findings
Our results elucidate how individuals cope with anger- and sadness-induced narrative misinformation. Specifically, sadness decreases susceptibility to narrative misinformation’s negative effects, and anger prompts intuitive actions. Narrative transportation deepened felt emotions and both coping processes, and corrections reduced the perceived truthfulness of misinformation.

Practical implications
Our findings offer practical strategies for mitigating misinformation by disrupting narrative transportation, particularly for anger-induced stories.

Social implications
Our findings can contribute to the development of targeted policies aimed at mitigating online misinformation dissemination and provide a roadmap to executing effective correction measures.

Originality/value
This study proposes and tests a theoretical model of people’s responses to narrative misinformation addressing both misinformation coping and risk coping through cognitive and behavioral routes. The model also explains how transportation, along with different appraisal tendencies, can intensify both coping processes.
Die Bedeutung der Grenze für die Heil- und Sonderpädagogik
Authors: Seitzer Philipp 
Published: September 2024

Abstract
Der folgende Beitrag untersucht die Grenze als pädagogischanthropologische Reflexionsfigur und deren Bedeutung für das Selbstverständnis und die Programmatik der Heil- und Sonderpädagogik. In diesem Zusammenhang wird auch die Frage gestellt, ob die Kritik, die innerhalb der Allgemeinen Pädagogik unter dem Stichwort „Optimierung als Entgrenzung“ formuliert wird, in ihrer Anwendung auf die Heil- und Sonderpädagogik Differenzierungen erfordert, die auch die fragliche Differenz dieser beiden Disziplinen tangieren. Nachdem in der Einleitung auf Optimierung eingegangen wird, ist im zweiten Schritt zunächst auf die Figur der Grenze unter pädagogischanthropologischen Aspekten einzugehen, ehe im dritten Schritt die Kritik der Entgrenzung konkretisiert wird. Anschließend wird das Verhältnis des heil- und sonderpädagogischen Diskurses zur Figur der Grenze befragt. Dies geschieht im Rahmen einer schlaglichtartigen historischsystematischen Untersuchung. Im Verlauf dieser Untersuchung lassen sich bestimmte Fragen, Probleme und Entwicklungslinien herausarbeiten, auf die im abschließenden Fazit Bezug genommen wird. Dieses gibt zudem einen Ausblick, wie mit offenen Problemen im Zusammenhang mit der Figur der Grenze in heil- und sonderpädagogischen Diskursen der Gegenwart umgegangen werden kann.
[113mIn]In-PSMA: high potential agent for SPECT imaging of prostate cancer
Authors: Akbari Leyla , Sina Sedigheh , Zolghadri Samaneh , Moghaddasi Ali , Hadad Kamal , Yousefnia Hassan 
Published: September 2024

Abstract
The prevalence rate of prostate cancer is very high and unfortunately causes many deaths worldwide. This study aimed to prepare [113mIn]In-PSMA as a novel agent for single photon emission computed tomography (SPECT) imaging of prostate cancer. 113mIn was eluted from an in-house made 113Sn/113mIn generator in chloride form, and its radionuclide, chemical and radiochemical purities was studied. [113mIn]In-PSMA was prepared with radiochemical purity (RCP) > 99 % under optimal labeling conditions. The biodistribution of the labeled compound was studied in normal rats, showed the major activity in the urine and kidneys as the main excretion route from the body. Considerable uptake was observed in the prostate and salivary glands as the PSMA-expressing organs. These data are in complete agreement with the other published data on PSMA-labeled compounds both in animals and humans. The results demonstrated [113mIn]In-PSMA can be considered as a good option for SPECT imaging of prostate cancer.
Efficacy and safety of sulforaphane-loaded emulsomes as tested on MCF7 and MCF10A cells
Authors: Karroum Reem , Üçışık Mehmet Hikmet 
Published: September 2024

Abstract

Objectives
Sulforaphane is well-known for its anti-cancer properties particularly against breast, skin and prostate cancers. High sensitivity of sulforaphane to oxygen, heat, and alkaline conditions, as well as its poor oral bioavailability and water instability limit its use in medicine. In this study, we aim to overcome the prementioned limitations by encapsulating sulforaphane within a lipid-based drug delivery system, known as emulsome, and investigate the anti-cancer features of the attained formulation.

Methods
The stability and dispersity of the formulation were assessed sequentially by zeta sizer, scanning electron microscopy and confocal laser scanning microscopy. Cell culture studies were performed to evaluate the anticancer activity of the formulation.

Results
Sulforaphane-loaded emulsomes with an average particle size of 246.0±14.1 nm, an average zeta potential of −23.5±2.4 mV and a polydispersity index of around 0.38 were produced. Encapsulations up to 0.036 mg/mL sulforaphane concentration was achieved. When MCF7 breast cancer cells were treated with sulforaphane-loaded emulsomes, a significant decrease was observed in proliferation of the cells along 72 h. In control group, emulsomes were found safe as tested at same concentrations on MCF-10a healthy cells. Applied as dissolved in DMSO, free sulforaphane with an IC50 value of 1.2 µM was more effective against MCF7 cells than sulforaphane-loaded emulsome formulation having a IC50 value 21.1 µM.

Conclusions
Sulforaphane-loaded emulsomes were obtained as stable, moderately disperse suspensions. Delivery of the bioactive compound into the cells were achieved. Yet, its biological activity remained behind its free form.
Prevalence and characteristics of ESBL-producing Salmonella in Weifang, China
Authors: Wang Xuesong , Wang Binglei , Lu Xiaohong , Ma Jie , Wang Zhanzhao , Wang Yuhui 
Published: September 2024

AbstractThis study examined the prevalence and antibiotic resistance pattern of blaCTX-M extended-spectrum β-lactamase positive Salmonella species isolated from a hospital in Weifang. Salmonella strains were isolated from hospitalized patients from January 2018 to April 2023. Whole-genome sequencing was performed by Illumina platform. CTX-M-producing Salmonella were identified by Comprehensive Antibiotic Research Database (CARD). Strain susceptibility to six antimicrobial agents was assessed by BD Phoenix™ M50 System. MLST analysis confirmed sequence types and additionally, serotypes were determined by SeqSero2. Genetic environments of blaCTX-M genes were analyzed by Isfinder and BLASTn. Single nucleotide polymorphisms were used to construct a phylogenetic tree to analyze homology. A total of 34 CTX-M-producing Salmonella were detected. The most prevalent serotype was Salmonella enterica subsp. enterica 1,4,[5],12:i:- (14/34, 41.18%), belonging to ST34, followed by Salmonella Enteritidis (10/34, 29.41%), belonging to ST11. The highest resistance rate was detected to ampicillin (97.06%), followed by ceftriaxone (94.12%) and ceftazidime (58.83%). In CTX-M-producing Salmonella five types of blaCTX-M genes were identified, the most prevalent was blaCTX-M-55 (47.06%, 16/34), followed by blaCTX-M-14, blaCTX-M-65, blaCTX-M-125, and blaCTX-M-27 at 26.47% (9/34), 11.77% (4/34), 8.82% (3/34), and 5.88% (2/34), respectively. Apart from blaCTX-M, 40 antibiotic resistance genes were also detected, conveying resistance to multiple drugs and the most frequent genes were namely, mcr-1.1, aph(6)-Id, aph(3″)-Ib, oqxAB, qnrB6, qnrS1. According to genetic environment analysis, the insertion sequence ISEcp1 was prevalent upstream of the blaCTX-M gene. Our study demonstrates that multiple resistance genes are carried by clinical isolates of Salmonella spp. however, the dominant ESBL genotype is CTX-M-55, that is associated with ISEcp1.