bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enthalpy relaxation of sodium aluminosilicate glasses from thermal analysis
Authors: Hauke Brittney M. , Mauro John C. 
Published: September 2024

AbstractThe sodium aluminosilicate (NAS) glass family is important for many different industrial applications, but glass relaxation has not yet been thoroughly studied in this system. Thermal analysis techniques such as differential scanning calorimetry (DSC) and modulated differential scanning calorimetry (MDSC) can provide insight into the enthalpy relaxation of glass by measuring the glass transition temperature (Tg), activation energy, and enthalpy of relaxation. MDSC is mostly used to study nonoxide and low Tg glasses, and there is much debate about whether the nonreversing heat flow analysis method is accurate. To the authors’ knowledge, this is the first paper using MDSC to study these NAS compositions, and one of few papers to report MDSC on high Tg oxide glasses. We report on one set of modulation conditions that obtain a linear response using Lissajous curves, as well as comparing the activation energy calculated from DSC with the enthalpy of relaxation obtained from MDSC. Our results show that the activation energy and enthalpy of relaxation do not give the same compositional minimum in relaxation, and therefore more work is needed to investigate the validity of the nonreversing heat flow approach for high Tg oxide glasses.
NEDD4L affects KLF5 stability through ubiquitination to control ferroptosis and radiotherapy resistance in oesophageal squamous cell carcinoma
Authors: Chen Jinjin , Ying Kaijun , Sun Jian , Wang Yao , Ji Mingming , Sun Yunhao 
Published: September 2024

AbstractOesophageal squamous cell carcinoma (ESCC) contributes to high mortality. Modulating ferroptosis may reverse resistance to radiotherapy. This article was to explore the ubiquitination modification of KLF5 and its effect on ferroptosis in ESCC. KLF5 was under‐expressed by shRNA plasmids in the cells and ROS levels were analysed by flow cytometry, ferroptotic gene expression was detected by qRT‐PCR, MDA and GSH levels were determined by ELISA, cell morphology was observed by transmission electron microscopy, and Fe ion levels were analysed by immunofluorescence. Cells were treated with Ferrostatin‐1 and NAC and analysed for cell proliferation by colony formation assay, cell migration and invasion by Transwell assays, and apoptosis by flow cytometry. DNA damage in cells was also analysed using comet assay, EdU doping assay, γH2AX fluorescence, DNA‐PKcs and PCR. NEDD4L and KLF5 binding was analysed by immunoprecipitation. Changes in ferroptosis, DNA damage and resistance were analysed in cells with both silencing NEDD4L and KLF5. Changes in tumour resistance to radiation were analysed in mice underexpressing NEDD4L and KLF5. Low expression of KLF5 significantly promotes cellular lipid peroxidation levels, with decreased expression of SOD and GPX4, and increased expression of ACSL4. Concurrently, MDA levels deplete GSH, and cells exhibit typical ferroptotic morphology with increased Fe2+ content. KLF5 inhibition results in enhanced cellular clonogenicity, migration and invasion activities, reduced apoptosis, increased tail DNA, nuclear EdU incorporation, nuclear γH2AX foci and elevated expression of DNA‐PKcs, LIG4, RAD9B and BMI1. Ferrostatin‐1 and NAC reverse these effects. NEDD4L ubiquitination modifies and degrades KLF5, with NEDD4L/KLF5 inhibition mitigating cellular ferroptosis and DNA damage, thereby promoting radiosensitivity both in vitro and in vivo. NEDD4L increases radiosensitivity by accelerating cellular ferroptosis via ubiquitination modification of KLF5.
Comprehensive characterization of long QT syndrome‐associated genes in cancer and development of a robust prognosis model
Authors: Xu Jincheng , Wen Zhengchao , She Yongtao , Li Maohao , Shen Xiuyun , Zhi Fengnan , Wang Shu , Jiang Yanan 
Published: September 2024

AbstractCancer is the leading public health problem worldwide. However, the side effects accompanying anti‐cancer therapies, particularly those pertaining to cardiotoxicity and adverse cardiac events, have been the hindrances to treatment progress. Long QT syndrome (LQTS) is one of the major clinic manifestations of the anti‐cancer drug associated cardiac dysfunction. Therefore, elucidating the relationship between the LQTS and cancer is urgently needed. Transcriptomic sequencing data and clinic information of 10,531 patients diagnosed with 33 types of cancer was acquired from TCGA database. A pan‐cancer applicative gene prognostic model was constructed based on the LQTS gene signatures. Meanwhile, transcriptome data and clinical information from various cancer types were collected from the GEO database to validate the robustness of the prognostic model. Furthermore, the expression level of transcriptomes and multiple clinical features were integrated to construct a Nomo chart to optimize the prognosis model. The ssGSEA analysis was employed to analysis the correlation between the LQTS gene signatures, clinic features and cancer associated signalling pathways. Our findings revealed that patients with lower LQTS gene signatures enrichment levels exhibit a poorer prognosis. The correlation of enrichment levels with the typical pathways was observed in multiple cancers. Then, based on the 17 LQTS gene signatures, we construct a prognostic model through the machine‐learning approaches. The results obtained from the validation datasets and training datasets indicated that our prognostic model can effectively predict patient outcomes across diverse cancer types. Finally, we integrated this model with clinical features into a nomogram, demonstrating its potential as a valuable prognostic tool for cancer patients. Our study sheds light on the intricate relationship between LQTS and cancer pathways. A LQTS feature based clinic decision tool was developed aiming to enhance precision treatment of cancer.
Involvement of the Wnt/β‐catenin signalling pathway in heterotopic ossification and ossification‐related diseases
Authors: Zhao Yike , Liu Fangzhou , Pei Yiran , Lian Fengyu , Lin Hui 
Published: September 2024

AbstractHeterotopic ossification (HO) is a pathological condition characterized by the formation of bone within soft tissues. The development of HO is a result of abnormal activation of the bone formation programs, where multiple signalling pathways, including Wnt/β‐catenin, BMP and hedgehog signalling, are involved. The Wnt/β‐catenin signalling pathway, a conserved pathway essential for various fundamental activities, has been found to play a significant role in pathological bone formation processes. It regulates angiogenesis, chondrocyte hypertrophy and osteoblast differentiation during the development of HO. More importantly, the crosstalk between Wnt signalling and other factors including BMP, Hedgehog signalling, YAP may contribute in a HO‐favourable manner. Moreover, several miRNAs may also be involved in HO formation via the regulation of Wnt signalling. This review aims to summarize the role of Wnt/β‐catenin signalling in the pathogenesis of HO, its interactions with related molecules, and potential preventive and therapeutic measures targeting Wnt/β‐catenin signalling.
Optimism and Overconfidence of Strategic Decision Makers‐Comparing Entrepreneurs and Managers With Employees
Authors: Chochoiek Nadine , Huber Laura Rosendahl , Sloof Randolph 
Published: September 2024

ABSTRACTEmpirical evidence supports the conventional wisdom that entrepreneurs are more optimistic and overconfident than others. However, the same holds true for (top) managers. In a large incentivized survey (), we directly compare entrepreneurs, managers, and employees on a comprehensive set of measures of optimism and overconfidence. We find that on average entrepreneurs and managers are more optimistic than employees in their dispositional optimism and their explanatory style of past events. However, they do not differ from each other in these respects. For two incentivized measures of overconfidence, we also find no differences between entrepreneurs and managers. Both are equally likely to overestimate their own abilities compared to employees. In terms of overestimating general economic prospects differences with employees are much less pronounced. Exploration of within‐group heterogeneities shows that these observations hold true for various subgroups of entrepreneurs and managers. Together these findings tentatively suggest that optimism and overconfidence characterize strategic decision makers more generally, irrespective of whether they bear the full risk of their strategic decisions.
Journeys to functionality: A dimensional analysis of personal narratives of recovery from depression
Authors: Settrisman Ryno , Mishra Ajit K 
Published: September 2024

AbstractBackgroundRecovery from depression constitutes a long journey that is understood as a unique and multifaceted process encompassing various dimensions. To understand what constitutes recovery from depression and to develop greater insights into the unique dimensions of the recovery journey, the study of recovery memoirs is essential.MethodThis article performs a dimensional analysis on six Indian first‐hand accounts of recovery from depression collected in Amrita Tripathi and Arpita Anand's Real Stories of Dealing with Depression to examine the journeys toward healing and the uniqueness of the recovery processes. Through the dimensional analysis, four core dimensions of recovery from depression—Problems, Social Supports, Position of Recovery and Functionality—are identified. The process of recovery, consisting of understanding the problems (causes) through sensed adversities (sensed effects), making use of received social supports to transform oneself, finding out the position of recovery, and lastly, functioning peacefully for living, corresponds to the four dimensions of recovery. Drawing on Herbert Blumer's theory of social interactionism, the article examines how different individuals interpret their experiences of depression in unique ways and develop distinctive recovery strategies.DiscussionThe identified dimensions of recovery correspond to the need for unique approaches to recovery articulated by each of the narrators. The selected narratives reveal that the problems are unique, and for each of the unique problems, there has to be a distinctive support mechanism. The recovery narratives are centred around the unique problems wherein the individuals attempt to understand what happened to them and why it happened.ConclusionThe article concludes by suggesting that healthcare practitioners can utilise the dimensions and the subdimensions as a lead to understand fully how their clients conceptualise their problems and try to understand how each client defines the recovery itself.
Inferring the metabolic rate of zebrafish from ventilation frequency
Authors: Han Tianjun , Lombardelli Giulia , Peterson Sean D. , Porfiri Maurizio 
Published: September 2024

AbstractFish schooling has attracted the interest of the scientific community for centuries. Energy savings have been long posited to be a key determinant for the emergence of schooling patterns. Yet, current methodologies do not allow the precise quantification of the metabolic rate of specific individuals within the school, typically leaving researchers with only a single, global measurement of metabolic rate for the collective. In this paper, we demonstrate the feasibility of inferring metabolic rate of swimming fish using the mouth‐opening frequency, a simple proxy that can be scored utilizing video recordings in the laboratory or in the field, even for small fish. The mouth‐opening frequency is independent of hydrodynamic interactions within the school, thereby mitigating potential confounding factors that arise when using locomotory measures associated with tail‐beat motion. We assessed the reliability of mouth‐opening frequency as a proxy for metabolic rate by conducting experiments on zebrafish (Danio rerio) using swimming respirometry. We varied the flow speed from 0.8 to 3.2 body lengths per second and extracted tail‐beat motion and mouth opening from video recordings. Our results revealed a strong correlation between oxygen uptake and mouth‐opening frequency for nonzero flow speeds but not in quiescent water. Contrary to our expectations, we did not find evidence in favor of the use of tail‐beat frequency as a proxy for metabolic rate. Overall, our results open the door to the study of individual metabolic rates in fish schools without confounding factors related to hydrodynamic interactions.
Combined Forehead and Temporal Lifting: An Innovative Approach to Lanluma V Treatment
Authors: Wu Larry , Salti Giovanni 
Published: September 2024

ABSTRACTBackgroundExcess skin laxity over the upper face can contribute to aging over the mid and lower face. We describe an innovative nonsurgical technique of facial rejuvenation by injecting Lanluma V over the scalp's vertex and parietal regions. Lanluma V is a poly‐l‐lactic acid (PLLA)‐based collagen stimulator which contains 210 mg of PLLA, distributed by Sinclair Pharmaceutical. Lanluma V works by stimulating collagen regeneration to provide support for the treated area.MethodA retrospective review of 12 consecutive patients treated with Lanluma V over the vertex and parietal regions of the scalp to achieve nonsurgical rejuvenation of the upper, middle, and lower thirds of the face was conducted. The patients were treated over two sessions, 1 month apart. The treated patients were reviewed by a plastic surgeon and rated under the Global Aesthetic Improvement Scale (GAIS) 6 months after treatment.ResultsThe patients achieved an overall average of 1.16 grade improvement in GAIS. The average follow‐up period is 6 months following completion of treatment. There was no reported incidence of non‐scarring alopecia, which has been reported in the use of other, more viscous fillers such as calcium hydroxyapatite or high G' hyaluronic acid.ConclusionThis innovative method of combined forehead and temporal lifting with Lanluma V allows for an average 1.16 grade improvement in GAIS. There is no reported incidence of non‐scarring alopecia, which has been associated with other fillers.
SOX4 inhibits ferroptosis and promotes proliferation of endometrial cancer cells via the p53/SLC7A11 signaling
Authors: Zhu Hongli , Xu Song 
Published: September 2024

AbstractAimSex‐determining region Y‐related high‐mobility group box 4 (SOX4) has been reported to play a carcinogenic role in endometrial cancer (EC). However, the biological function and regulatory mechanisms of SOX4 in ferroptosis during the progression of EC are still unknown.MethodsThe mRNA and protein levels were scrutinized by quantitative reverse‐transcription polymerase chain reaction and western blot, respectively. The cell viability and proliferative capability were determined by cell counting kit‐8 assay and 5‐ethynyl‐2′‐deoxyuridine (EdU) assay. Transcriptional regulation of gene expression was investigated by dual‐luciferase reporter assay and chromatin immunoprecipitation. Ferroptosis was evaluated by detection of reactive oxygen species, malondialdehyde, Fe2+, and ferroptosis‐related proteins. The mice test was implemented to confirm the influence of SOX4 on EC tumor growth and ferroptosis in vivo.ResultsWe here discovered the elevation of SOX4 in EC tissues and cells. Functionally, SOX4 knockdown hampered proliferation and promoted ferroptosis of EC cells. Mechanistically, SOX4 bound to p53 promoter and inhibited its transcriptional activity in EC cells. In addition, p53 transcriptionally suppressed SLC7A11 expression in EC cells. Downregulation of p53 reverses the effect of SOX4 knockdown on proliferation and ferroptosis of EC cells. Finally, in vivo experiments demonstrated that SOX4 depletion hindered tumor growth and triggered ferroptosis in EC.ConclusionsThese findings collectively suggested that SOX4 inhibited ferroptosis and promoted proliferation of EC cells via the p53/SLC7A11 signaling. Our research unveiled a novel regulatory mechanism of ferroptosis in EC, offering promising perspectives for the development of EC therapies.
Abandonment of paediatric peripheral intravenous catheter insertion in the emergency department: A retrospective cohort study
Authors: Clarke Zoe , Lam Clayton , Sweeny Amy L , Snelling Peter J 
Published: September 2024

AimChildren and their families have reported peripheral intravenous catheter (PIVC) insertion as the most stressful part of their emergency department (ED) encounter, with some enduring multiple attempts without a successful insertion. The purpose of this study was to identify factors associated with abandonment of paediatric PIVC insertion.MethodsA retrospective cohort study was conducted at the Gold Coast University Hospital. All patients 16 years of age and younger, presented in 2019 with a PIVC insertion attempted in the ED were eligible. The electronic medical records were screened by two reviewers to identify those who required a PIVC insertion. Logistic regression analysis was performed to assess variables associated with PIVC insertion abandonment.ResultsOf 6394 records screened, 2401 (8.3%) had a PIVC insertion attempted, with 99 (4.1%) being abandoned. Age <12 months was the strongest predictor of PIVC abandonment at a rate of 11.3% (38/336), with a >10‐fold increased risk for infants less than 3 months old and 3–12 months old; adjusted odds ratio (95% confidence interval) 12.4 (5.1–30.2) and 14.8 (5.8–37.4), respectively. Indications of ‘infection’ or ‘rehydration’ were associated with a decreased likelihood of abandonment when compared to ‘investigation only’ in multivariate modelling (odds ratio (95% confidence interval): 0.181 (0.099–0.332) and 0.262 (0.100–0.686), respectively).ConclusionsThis study suggests the rate of PIVC insertion abandonment in children is relatively infrequent. However, more than one in 10 children aged <12 months had PIVC attempts without successful insertion. PIVC abandonment was less likely when there was an indication that necessitated PIVC insertion, such as a serious bacterial infection.
“(…) here I have freedom”—A study of refugees' and asylum seekers' legal consciousness in Greece: Self‐identity, human rights, and expectations from European Union law
Authors: Graca Sofia , Kapageorgiadou Violeta 
Published: September 2024

AbstractThis paper adds to the existing knowledge on migration and the law by empirically exploring the legal consciousness of 33 refugees and asylum seekers in Greece, more specifically, by discussing how their experiences, self‐identity and expectations of the law inform their reactions to the restrictions imposed upon them. The findings suggest that (1) legal knowledge is acquired in the countries of origin and from contact with smugglers, other migrants, law enforcement agents and staff from NGOs; (2) this knowledge allows them to forge an identity as “rights‐bearers,” which (3) together with perceptions and expectations of human rights law and European Union policies on migration, (4) empower them to claim protection from the Greek state, and (5) legitimizes their actions, even if these sometimes involve subterfuge. Despite their particularly vulnerable positions, refugees and asylum seekers are, therefore, not mere passive receivers of state power, but also try to use the law to overcome adversity, in an almost game‐like fashion.
Upholding our PROMISE: Increased representation is not enough to foster belonging in graduate medical education
Authors: Poitevien Patricia , Kas‐Osoka Oriaku , Burns Audrea , Prakash Laura Kester , Marbin Jyothi , Schwartz Alan , Lucas Candice Taylor , Yemane Lahia , Blankenburg Rebecca 
Published: September 2024

AbstractPurposeSense of belonging supports academic achievement and encourages career endurance. The purpose of this study was to characterize what individual and institutional factors influence one's sense of belonging by describing the experiences of underrepresented in medicine (UIM) paediatric and internal medicine–paediatric residents in the United States.MethodThe authors conducted a national survey of paediatric and internal medicine–paediatric residents. The 23‐item anonymous web‐based survey was distributed between October 2020 and January 2021 and included questions on socio‐demographic characteristics and individual perceptions on sense of belonging, value, common mission or values at a program or institution and respect. The authors used linear mixed models and fitted regression models to examine individual factors and environmental factors that impact sense of belonging, value and respect.ResultsAcross 29 residency programs, 938 (53%) of 1748 residents completed the survey. One hundred sixty‐seven (18%) self‐identified as UIM. UIM residents had a lower sense of belonging than non‐UIM residents [mean (SD) 3.6 (0.87) vs. 4.0 (0.57)]. Black/AA and Hispanic/Latinx residents had the lowest sense of belonging [3.5 (0.82) and 2.8 (0.93), respectively]. UIM residents demonstrated decreased sense of belonging in programs that lacked bias training and where peers discriminated against them. Sense of belonging was increased in programs where they perceived a sense of support, respect or values alignment. Surprisingly, individual UIM resident sense of belonging was not improved by having more UIM residents in a program.ConclusionUIM paediatric residents experience a decreased sense of belonging during training. Programs can support sense of belonging for UIM residents by demonstrating respect and support for them and by offering systems for bias training and reporting bias and discrimination. Recruiting a greater number of UIM trainees remains important; however, compositional diversity alone does not improve a sense of belonging for UIM residents. There is continued need for structural/institutional change, including addressing institutional culture and structural racism.
PeFUS3 Drives Lateral Root Growth Via Auxin and ABA Signalling Under Drought Stress in Populus
Authors: Liu Shu‐Jing , Zhang Han , Jin Xiao‐Ting , Niu Meng‐Xue , Feng Cong‐Hua , Liu Xiao , Liu Chao , Wang Hou‐Ling , Yin Weilun , Xia Xinli 
Published: September 2024

ABSTRACTChanges in root system architecture are vital for plant adaptation to drought stress, yet the underlying molecular mechanisms of this process remain largely elusive. Here, FUSCA3 (FUS3), a B3 domain transcription factor isolated from Populus euphratica, was found to be an important gene of regulating lateral root (LR) development under drought stress. The expression of PeFUS3 was strongly induced by ABA and dehydration treatments. Overexpressing PeFUS3 in poplar 84 K (P. alba × P. glandulosa) positively regulated LR growth and enhanced drought tolerance, while the knockout lines, generated by the CRISPR/Cas9 system, displayed repressed LR growth and weakened drought tolerance. Further investigation demonstrated that PeFUS3 activated the expression of PIN2, PIN6a and AUX1, which were key genes involved in auxin transport, suggesting PeFUS3 modulated LR development under drought stress through auxin signalling. Moreover, PeFUS3 directly upregulated PePYL3 expression, and overexpressing PePYL3 poplar lines exhibited significantly increased drought resistance. In addition, PeABF2, an ABA responsive transcription factor, interacted with PeFUS3 and activated its transcription, indicating PeFUS3 was involved in ABA signalling pathway. Taken together, PeFUS3 is a key regulator, maintaining root growth of poplar by modulating the crosstalk of auxin and ABA signalling under drought stress.