bluuebunny/crossref_metadata_2025_split huggingface dataset:
Honokiol Exhibits Anti-Tumor Effects in Breast Cancer by Modulating the miR-148a-5p-CYP1B1 Axis
Authors: Han Xuejiao , Cheng Yuan , Jiang Zedong , Alu Aqu , Ma Xuelei 
Published: September 2024

Breast cancer (BC) is the most frequently diagnosed malignancy in female patients. There is a significant lack of therapeutic strategies for BC, particularly triple-negative breast cancer (TNBC). Honokiol (HNK), a lignin extracted from the Magnolia genus plant, has demonstrated numerous pharmacological effects. Therefore, this study aims to investigate the antitumor effect of HNK on BC cells and employ high-throughput sequencing to elucidate its potential mechanism. We found that HNK significantly inhibited proliferation and induced apoptosis on BC cell lines in a dose-dependent manner. Moreover, HNK treatment suppressed migration and colony formation and initiated the intrinsic apoptotic pathway specifically in MDA-MB-231 cells. High-throughput sequencing and bioinformatics analysis revealed that miR-148a-5p expression was significantly up-regulated, whereas CYP1B1 expression was down-regulated following HNK treatment. Importantly, survival analysis based on TCGA database showed high miR-148a-5p expression was correlated with a better prognosis for BC patients. Inhibition of miR-148a-5p by inhibitor not only increased cell viability but also attenuated apoptosis induced by HNK. Finally, a strong synergistic effect between HNK and paclitaxel was observed in vitro. In conclusion, our study validated the antitumor efficacy of HNK against human BC cells and elucidated its underlying mechanism through high-throughput sequencing, thereby providing compelling evidence for further exploration of the potential clinical application of HNK towards the treatment of BC.
Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers
Authors: Medina Jamie E. , Annapragada Akshaya V. , Lof Pien , Short Sarah , Bartolomucci Adrianna L. , Mathios Dimitrios , Koul Shashikant , Niknafs Noushin , Noë Michaël , Foda Zachariah H. , Bruhm Daniel C. , Hruban Carolyn , Vulpescu Nicholas A. , Jung Euihye , Dua Renu , Canzoniero Jenna V. , Cristiano Stephen , Adleff Vilmos , Symecko Heather , van den Broek Daan , Sokoll Lori J. , Baylin Stephen B. , Press Michael F. , Slamon Dennis J. , Konecny Gottfried E. , Therkildsen Christina , Carvalho Beatriz , Meijer Gerrit A. , Andersen Claus Lindbjerg , Domchek Susan M. , Drapkin Ronny , Scharpf Robert B. , Phallen Jillian , Lok Christine A.R. , Velculescu Victor E. 
Published: September 2024

Abstract
Ovarian cancer is a leading cause of death for women worldwide, in part due to ineffective screening methods. In this study, we used whole-genome cell-free DNA (cfDNA) fragmentome and protein biomarker [cancer antigen 125 (CA-125) and human epididymis protein 4 (HE4)] analyses to evaluate 591 women with ovarian cancer, with benign adnexal masses, or without ovarian lesions. Using a machine learning model with the combined features, we detected ovarian cancer with specificity &gt;99% and sensitivities of 72%, 69%, 87%, and 100% for stages I to IV, respectively. At the same specificity, CA-125 alone detected 34%, 62%, 63%, and 100%, and HE4 alone detected 28%, 27%, 67%, and 100% of ovarian cancers for stages I to IV, respectively. Our approach differentiated benign masses from ovarian cancers with high accuracy (AUC = 0.88, 95% confidence interval, 0.83–0.92). These results were validated in an independent population. These findings show that integrated cfDNA fragmentome and protein analyses detect ovarian cancers with high performance, enabling a new accessible approach for noninvasive ovarian cancer screening and diagnostic evaluation.

Significance:
There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.
Combined KRAS Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous PDAC Model
Authors: Liu Yonghong , Han Jincheng , Hsu Wen-Hao , LaBella Kyle A. , Deng Pingna , Shang Xiaoying , Tallón de Lara Paulino , Cai Li , Jiang Shan , DePinho Ronald A. 
Published: September 2024

Abstract
Pancreatic ductal adenocarcinoma (PDAC) resists conventional chemo/radiation and immunotherapy (IO). In PDAC, oncogenic KRAS (KRAS*) drives glycolysis in cancer cells to consume available glucose and produce abundant lactate, creating profound immune suppression in the tumor microenvironment. In this study, we combined KRAS* inhibition with agents targeting the major arms of the immunity cycle: CXCR1/2 inhibitor for myeloid cells, antagonistic anti-LAG3 antibody for T cells, and agonistic anti-41BB antibody for dendritic cells. This combination elicited robust antitumor regression in iKPC mice bearing large autochthonous tumors. Whereas untreated mice succumbed within 3 weeks, sustained treatment led to durable complete tumor regression and prolonged survival in 36% of mice at 6 months. Mechanistic analyses revealed enhanced T-cell infiltration and activation, depletion of immunosuppressive myeloid cells, and increased antigen cross-presentation by dendritic cells within the tumor core. These findings highlight the promise of KRAS* inhibitors alongside IO as a potential PDAC treatment avenue, warranting clinical investigation.

Significance:
Clinically available KRAS* inhibitors and IO agents alleviated the immunosuppressive tumor microenvironment in PDAC. Profound tumor regression and prolonged survival in an autochthonous PDAC model provide a compelling rationale for combining KRAS* inhibition with IO agents targeting multiple arms of the immunity cycle to combat PDAC.
Coronary Plaque Characteristics in Patients With Chronic Kidney Failure: Impact on Cardiovascular Events and Mortality
Authors: Dahl Jonathan Nørtoft , Nielsen Marie B. , Rasmussen Laust D. , Ivarsen Per , Williams Michelle C. , Svensson My Hanna Sofia , Birn Henrik , Bøttcher Morten , Winther Simon 
Published: September 2024

BACKGROUND:
In patients with coronary artery disease, coronary plaques with high-risk features and low-attenuation plaque burden are independent measures associated with major adverse cardiovascular events (MACEs). Patients with chronic kidney failure may have different coronary artery disease characteristics. The aim was to assess the association of coronary plaque characteristics and coronary artery disease extent with MACE and all-cause mortality in patients with chronic kidney failure.

METHODS:
Potential kidney transplant candidates who underwent coronary computed tomography angiography as part of the cardiac screening program before kidney transplantation were included. We evaluated high-risk plaques and diameter stenosis semiqualitatively and quantified coronary artery calcium score and plaque burden (percentage atheroma volume).

RESULTS:

In 484 patients with chronic kidney failure and few or no symptoms of coronary artery disease (mean age, 53±12 years; 62% men; 32% on dialysis), 56 (12%) patients suffered MACE and 69 (14%) patients died during a median follow-up of 4.9 years. High-risk plaques were present in 39 (70%) patients with MACE. Median calcified plaque burden was 3.7% in patients with MACE versus 0.2% in patients without MACE. The median low-attenuation plaque burden was 0.3% versus 0.03%, respectively. In semiqualitative analyses, the presence of high-risk plaque and a higher coronary artery calcium score were associated with increased risk of MACE (hazard ratio (HR), 2.0 [95% CI, 1.0–3.7];
P
=0.040; HR, 1.2 [95% CI, 1.0–1.3];
P
=0.014), respectively. Neither were associated with all-cause mortality. In quantified analysis, increasing levels of both calcified and low-attenuation plaque burdens were associated with risk of MACE (HR, 2.6 [95% CI, 1.8–3.7];
P
<0.001; HR, 2.6 [95% CI, 1.5–4.5];
P
=0.001 [per variable doubling, respectively]) and all-cause mortality (HR, 1.6 [95% CI, 1.2–2.1];
P
=0.002; HR, 1.8 [95% CI, 1.1–3.0];
P
=0.028, respectively).

CONCLUSIONS:
In patients with chronic kidney failure, calcified and low-attenuation plaque burdens were independently associated with MACE and all-cause mortality, while high-risk plaques and coronary artery calcium score were only associated with MACE.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01344434.
Evaluating Synthetic Data Generation from User Generated Text
Authors: Chim Jenny , Ive Julia , Liakata Maria 
Published: September 2024

Abstract
User-generated content provides a rich resource to study social and behavioral phenomena. Although its application potential is currently limited by the paucity of expert labels and the privacy risks inherent in personal data, synthetic data can help mitigate this bottleneck. In this work, we introduce an evaluation framework to facilitate research on synthetic language data generation for user-generated text. We define a set of aspects for assessing data quality, namely, style preservation, meaning preservation, and divergence, as a proxy for privacy. We introduce metrics corresponding to each aspect. Moreover, through a set of generation strategies and representative tasks and baselines across domains, we demonstrate the relation between the quality aspects of synthetic user generated content, generation strategies, metrics, and downstream performance. To our knowledge, our work is the first unified evaluation framework for user-generated text in relation to the specified aspects, offering both intrinsic and extrinsic evaluation. We envisage it will facilitate developments towards shareable, high-quality synthetic language data.
What Is Faster than Where in Vocal Emotional Perception
Authors: Temudo Sara , Pinheiro Ana P. 
Published: September 2024

Abstract
Voices carry a vast amount of information about speakers (e.g., emotional state; spatial location). Neuroimaging studies postulate that spatial (“where”) and emotional (“what”) cues are processed by partially independent processing streams. Although behavioral evidence reveals interactions between emotion and space, the temporal dynamics of these processes in the brain and its modulation by attention remain unknown. We investigated whether and how spatial and emotional features interact during voice processing as a function of attention focus. Spatialized nonverbal vocalizations differing in valence (neutral, amusement, anger) were presented at different locations around the head, whereas listeners discriminated either the spatial location or emotional quality of the voice. Neural activity was measured with ERPs of the EEG. Affective ratings were collected at the end of the EEG session. Emotional vocalizations elicited decreased N1 but increased P2 and late positive potential amplitudes. Interactions of space and emotion occurred at the salience detection stage: neutral vocalizations presented at right (vs. left) locations elicited increased P2 amplitudes, but no such differences were observed for emotional vocalizations. When task instructions involved emotion categorization, the P2 was increased for vocalizations presented at front (vs. back) locations. Behaviorally, only valence and arousal ratings showed emotion–space interactions. These findings suggest that emotional representations are activated earlier than spatial representations in voice processing. The perceptual prioritization of emotional cues occurred irrespective of task instructions but was not paralleled by an augmented stimulus representation in space. These findings support the differential responding to emotional information by auditory processing pathways.
The United Nations’ Obligation to Provide Access to Remedies to Third-Party Claimants Under International Law
Authors: Picard Doris Uwicyeza 
Published: September 2024

Abstract
The perceived impunity of the United Nations peacekeeping missions has been the subject of numerous reports and studies. These studies are in agreement that the legal accountability of the UN is strongly challenged by the UN’s absolute immunity coupled with a lack of or inadequate alternative dispute resolution mechanisms. This situation has led to what is referred to as a ‘remedy gap’ whereby third-party claims against the UN are extinguished due to a lack of forum with jurisdiction over the UN. This article is a study into the second component of the remedy gap, namely, the lack of or inadequate alternative dispute resolution mechanisms. This is a study on the underlying obligation to provide access to remedies as a potential component of the remedy gap. It seeks to assess the legal framework of the UN’s obligation to provide access to remedies and the scope thereof. This is to establish whether the lack of or shortfalls of the UN’s alternative dispute resolution mechanisms are imputable to an inadequate legal framework which does not provide sufficient legal tools to ensure the suitable adjudication of claims or whether the issue lies in the implementation phase through the UN’s policies and practice. In essence, this article seeks to determine the basic rules that form part of the UN’s obligation to provide access to remedies. This is done through a comprehensive analysis of all the possible sources of this obligation to determine its scope.
Open Innovation: Accomplishments and Prospects for the Next 20 Years
Authors: Chesbrough Henry 
Published: September 2024

Summary I have been invited to discuss the prospects for Open Innovation (OI) as part of this special issue of the California Management Review. To organize my discussion, I will examine three phases of the evolution of this concept: the antecedents of OI, some of the main findings from OI (including both successes and failures), and prospects for the future of OI.
3D-printed broadband electromagnetic wave-absorbing basalt/CF/PLA composites with a high current path for lightning strike protection
Authors: Noh Ji-Sub , Hong So-Mang , Hoang Van-Tho , Kwak Byeong-Su , Nam Young-Woo 
Published: September 2024

In this study, we used the three-dimensional (3D) printing method to design and fabricate a radar-absorbing structure (RAS) to protect against damage caused by lightning strikes. A carbon black-dispersed 3D filament was used as reinforcement in the composite, and metalized fibers served as the feedstock for 3D-printing. The return losses measured in the X-band and Ku-band (8.2–18 GHz) indicated a maximum return loss of −28.98 dB at 10.68 GHz, with a broad bandwidth of 6.56 GHz in the frequency range of 8.2-18 GHz. A coupled electrical–thermal analysis confirmed that the proposed carbon black-dispersed filament provided conductive paths, which contributed to direct current, energy dissipation, and lightning strike protection. The 3D-printing method ensured a sufficient level of electrical conductivity, limiting the area and depth of damage caused by lightning strikes. Therefore, 3D-printed-RASs, reinforced by electrically conductive materials, can effectively protect against lightning strikes.
The international dissemination of China’s English academic journals on Twitter: Structure, theme and impact
Authors: Hou Jianhua , Wang Yuanyuan , Wang Dongyi , Fang Wenxi , Zhang Yang 
Published: September 2024

Objective/Significance: To measure the international communication capacity of China’s English academic journal papers based on social media platforms. Method/Process: Social network analysis, content analysis and emotion analysis were used to describe the diffusion structure of China’s English academic journal papers on Twitter from the aspects of network structure and identify important node users, explore the identity characteristics and emotion characteristics of users as well as diffusion capability of journals of different disciplines. Conclusion/Discovery: Journal articles in the fields of natural sciences and engineering as well as humanities and social sciences exhibit a strong positive correlation between their diffusion structure and network size. Networks with a mixed diffusion structure typically have larger network sizes. The users occupying key positions in the diffusion network typically have profile information that is academically relevant. The retweets and comments are mainly statements without emotional inclination, and the comments are mainly summary descriptions of the papers. The distribution of diffusion width, diffusion strength and diffusion speed of each discipline is significantly different. There is a significant positive correlation between the diffusion structure of papers and their diffusion capabilities. Innovation/Value: To reveal the diffusion structure and characteristics of China’s English academic journal papers on social media platforms, so as to provide reference for expanding the visibility of China’s English academic journals and improving the international dissemination capacity of China’s English journals.
Sleep Health Composite and Diabetes Symptom Burden in Young Adults With Type 1 Diabetes
Authors: Griggs Stephanie , Armentrout Bethany L. , Horvat Davey Christine , Hickman Ronald L. 
Published: September 2024

Introduction: Multiple individual sleep health dimensions (satisfaction, regularity, and duration) are associated with diabetes symptoms, precursors to micro-and macrovascular complications, among young adults with type 1 diabetes mellitus (T1DM). Nearly half of young adults with T1DM develop vascular complications; however, modifiable contributors of diabetes symptoms, including sleep health, have been understudied. Methods: This cross-sectional quantitative descriptive study involved the completion of multiple validated self-report questionnaires and the collection of raw continuous glucose monitor and diary data over a 14-day period. The sleep health composite score was calculated by summing the number of dimensions with “good” sleep health. Chronotype was estimated with the 19-item Morningness-Eveningness Questionnaire. Multiple linear regression analyses were conducted to evaluate the associations between the independent variables (sleep health composite and chronotype) and diabetes symptom burden. Covariates, including age, race, sex at birth, T1D duration, continuous subcutaneous insulin infusion use, and hemoglobin A1C (HbA1C), were considered to determine their contribution to these relationships. Results: One hundred nineteen young adults with T1DM who were aged 18 to 26 years were included in this study from 2 cohorts. Higher sleep health composite scores were associated with a lower overall diabetes symptom burden, even after adjusting for covariates in the linear regression models. Initially, a later chronotype was linked to a higher diabetes symptom burden, but this association became insignificant after accounting for HbA1C levels. Conclusion: Improving multiple dimensions of sleep health may alleviate the diabetes symptom burden among young adults with T1DM.
Unidentified CYP2D6 genotype does not affect pharmacological treatment for patients with first episode psychosis
Authors: De Brabander Emma Y , van Amelsvoort Thérèse , van Westrhenen Roos ,   GROUP Investigators
Published: September 2024

Background: Research on the pharmacogenetic influence of hepatic CYP450 enzyme 2D6 ( CYP2D6) on metabolism of drugs for psychosis and associated outcome has been inconclusive. Some results suggest increased risk of adverse reactions in poor and intermediate metabolizers, while others find no relationship. However, retrospective designs may fail to account for the long-term pharmacological treatment of patients. Previous studies found that clinicians adapted risperidone dose successfully without knowledge of patient CYP2D6 phenotype. Aim: Here, we aimed to replicate the results of those studies in a Dutch cohort of patients with psychosis ( N = 418) on pharmacological treatment. Method: We compared chlorpromazine-equivalent dose between CYP2D6 metabolizer phenotypes and investigated which factors were associated with dosage. This was repeated in two smaller subsets; patients prescribed pharmacogenetics-actionable drugs according to published guidelines, and risperidone-only as done previously. Results: We found no relationship between chlorpromazine-equivalent dose and phenotype in any sample (complete sample: p = 0.3, actionable-subset: p = 0.82, risperidone-only: p = 0.34). Only clozapine dose was weakly associated with CYP2D6 phenotype ( p = 0.03). Conclusion: Clinicians were thus not intuitively adapting dose to CYP2D6 activity in this sample, nor was CYP2D6 activity associated with prescribed dose. Although the previous studies could not be replicated, this study may provide support for existing and future pharmacogenetic research.
A Strike: Lessons in Solidarity
Authors: Rosenberg Daniel 
Published: September 2024

This is an account, by a faculty member, of a successful clerical workers’ strike at Long Island’s Adelphi University that took place in 1989. The author explains that neither the unionized full-time faculty nor the contingent instructors, whose status was quite precarious, could honor the clerical workers’ picket lines. Nonetheless, faculty and other nonstriking employees found numerous ways to support the strike. Student strike support manifestations were equally consistent and varied. JEL Classification: J51, J52, J30
Myoclonus After Cardiac Arrest did not Correlate with Cortical Response on Somatosensory Evoked Potentials
Authors: Koek Adriana Y. , Darpel Kyle A. , Mihaylova Temenuzhka , Kerr Wesley T. 
Published: September 2024

Purpose Myoclonus after anoxic brain injury is a marker of significant cerebral injury. Absent cortical signal (N20) on somatosensory evoked potentials (SSEPs) after cardiac arrest is a reliable predictor of poor neurological recovery when combined with an overall clinical picture consistent with severe widespread neurological injury. We evaluated a clinical question of if SSEP result could be predicted from other clinical and neurodiagnostic testing results in patients with post-anoxic myoclonus. Methods Retrospective chart review of all adult patients with post-cardiac arrest myoclonus who underwent both electroencephalographic (EEG) monitoring and SSEPs for neuroprognostication. Myoclonus was categorized as “non-myoclonic movements,” “myoclonus not captured on EEG,” “myoclonus without EEG correlate,” “myoclonus with EEG correlate,” and “status myoclonus.” SSEP results were categorized as all absent, all present, N18 and N20 absent bilaterally, and N20 only absent bilaterally. Cox proportional hazards with censoring was used to evaluate the association of myoclonus category, SSEP results, and confounding factors with survival. Results In 56 patients, median time from arrest to either confirmed death or last follow up was 9 days. The category of myoclonus was not associated with SSEP result or length of survival. Absence of N20 s or N18 s was associated with shorter survival (N20 hazard ratio [HR] 4.4, p = 0.0014; N18 HR 5.5, p < 0.00001). Conclusions Category of myoclonus did not reliably predict SSEP result. SSEP result was correlated with outcome consistently, but goals of care transitioned to comfort measures only in all patients with present peripheral potentials and either absent N20 s only or absence of N18 s and N20 s. Our results suggest that SSEPs may retain prognostic value in patients with post-anoxic myoclonus.