bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sphincterotomy with endoscopic biliary drainage for severe acute cholangitis: a meta-analysis
Authors: Sawas Tarek , Arwani Noura , Al Halabi Shadi , Vargo John 
Published: February 2017

Abstract
Aims To investigate the role of endoscopic sphincterotomy (ES) with endoscopic biliary drainage (EBD) in acute severe obstructive cholangitis management by performing a meta-analysis of controlled trials.
Method We searched PubMed and Embase for controlled studies that compared endoscopic drainage with ES versus Non-ES in acute obstructive cholangitis. Two reviewers selected the studies and extracted the data. Disagreement was addressed by a third reviewer. Heterogeneity of the studies was analyzed by Cochran’s Q statistics. A Mantel–Haenszel risk ratio was calculated utilizing a random effects model.
Results Four controlled studies met our inclusion criteria with 392 participants (201 ES, 191 Non-ES). The outcomes were drainage insertion success rate, drainage effectiveness, post drainage pancreatitis, bleeding, procedure duration, perforation, cholecystitis, and 30-day mortality. Drainage insertion success rate was identical in both groups (RR: 1.00, 95 %CI% 0.96 – 1.04). Effective drainage was not significantly different (RR: 1.11, 95 %CI 0.73 – 1.7). There was no significant difference in the incidence of pancreatitis post EBD between the ES and Non-ES groups at 3 % and 4 %, respectively (RR: 0.73, 95 %CI 0.24 – 2.27). However, there was a significant increase in post EBD bleeding with ES compared to Non-ES (RR: 8.58, 95 %CI 2.03 – 36.34). Thirty-day mortality was similar between ES and Non-ES groups at 0.7 % and 1 %, respectively (RR: 0.5, 95 %CI 0.05 – 5.28).
Conclusion Our findings show that EBD without ES is an effective drainage technique and carries less risk for post procedure bleeding. Patients who are critically ill and have coagulopathy should be spared from undergoing ES in the acute phase.
Skleritis – Fortschritte zur Diagnose und Therapie
Authors: Pohlmann D. , Pleyer U. 
Published: February 2017

ZusammenfassungDie Skleritis umfasst ein breites Spektrum morphologischer Veränderungen, die häufig im Rahmen systemischer Erkrankungen auftreten. Während die Episkleritis meist unproblematisch verläuft, ist die Skleritis oft durch einen destruierenden Verlauf charakterisiert. Dies führt nicht selten zu visusrelevanten Folgekomplikationen, die sich als ulzerative Keratitis, Uveitis oder sekundäre intraokulare Drucksteigerung präsentieren. Aufgrund der Schwere dieser Entzündungsform und der häufig zugrunde liegenden Grunderkrankungen soll der Fokus des Beitrags auf die differenzialdiagnostischen Überlegungen und die aktuellen therapeutischen Optionen gelegt werden.
The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix
Authors: Nagasato Ayaka Ichikawa , Yamashita Hiroshi , Matsuo Michinori , Ueda Kazumitsu , Kioka Noriyuki 
Published: February 2017

Abstract
Extracellular matrix (ECM) stiffness regulates cell differentiation, survival, and migration. Our previous study has shown that the interaction of the focal adhesion protein vinculin with vinexin α plays a critical role in sensing ECM stiffness and regulating stiffness-dependent cell migration. However, the mechanism how vinculin–vinexin α interaction affects stiffness-dependent cell migration is unclear. Lipid rafts are membrane microdomains that are known to affect ECM-induced signals and cell behaviors. Here, we show that vinculin and vinexin α can localize to lipid rafts. Cell-ECM adhesion, intracellular tension, and a rigid ECM promote vinculin distribution to lipid rafts. The disruption of lipid rafts with Methyl-β-cyclodextrin impaired the ECM stiffness-mediated regulation of vinculin behavior and rapid cell migration on rigid ECM. These results indicate that lipid rafts play an important role in ECM-stiffness regulation of cell migration via vinculin.
Parametrized bar recursion: a unifying framework for realizability interpretations of classical dependent choice
Authors: Powell Thomas 
Published: February 2017

Abstract
During the last 20 years or so, a wide range of realizability interpretations of classical analysis have been developed. In many cases, these are achieved by extending the base interpreting system of primitive recursive functionals with some form of bar recursion, which realizes the negative translation of either countable or countable dependent choice. In this work, we present the many variants of bar recursion used in this context as instantiations of a parametrized form of backward recursion, and give a uniform proof that under certain conditions this recursor realizes a corresponding family of parametrized dependent choice principles. From this proof, the soundness of most of the existing bar recursive realizability interpretations of choice, including those based on the Berardi–Bezem–Coquand functional, modified realizability and the more recent products of selection functions of Escardó and Oliva, follows as a simple corollary. We achieve not only a uniform framework in which familiar realizability interpretations of choice can be compared, but show that these represent just simple instances of a large family of potential interpretations of dependent choice principles.
Globicatella sanguinis Osteomyelitis and Bacteremia: Review of an Emerging Human Pathogen with an Expanding Spectrum of Disease
Authors: Miller Andy O. , Buckwalter Seanne P. , Henry Michael W. , Wu Fann , Maloney Katherine F. , Abraham Bisrat K. , Hartman Barry J. , Brause Barry D. , Whittier Susan , Walsh Thomas J. , Schuetz Audrey N. 
Published: February 2017

AbstractBackgroundGlobicatella sanguinis is an uncommon pathogen that may be misdiagnosed as viridans group streptococci. We review the literature of Globicatella and report 2 clinical cases in which catalase-negative Gram-positive cocci resembling viridans group streptococci with elevated minimum inhibitory concentrations (MICs) to ceftriaxone were inconsistently identified phenotypically, with further molecular characterization and ultimate identification of G sanguinis.MethodsTwo clinical strains (from 2 obese women; 1 with a prosthetic hip infection and the other with bacteremia) were analyzed with standard identification methods, followed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry, 16S recombinant ribonucleic acid (rRNA), and sodA polymerase chain reaction (PCR). The existing medical literature on Globicatella also was reviewed.ResultsStandard phenotypic methods failed to consistently identify the isolates. 16S PCR yielded sequences that confirmed Globicatella species. sodA sequencing provided species-level identification of G sanguinis. The review of literature reveals G sanguinis as an increasingly reported cause of infections of the urine, meninges, and blood. To our knowledge, this is the first reported case of an orthopedic infection caused by Globicatella sanguinis. A review of the 37 known cases of G sanguinis infection revealed that 83% of patients are female, and 89% are at the extremes of age (&lt;5 or &gt;65 years).ConclusionsGlobicatella sanguinis, an uncommon pathogen with elevated minimum inhibitory concentrations to third-generation cephalosporins, is difficult to identify by phenotypic methods and typically causes infections in females at the extremes of age. It may colonize skin or mucosal surfaces. Advanced molecular techniques utilizing 16S rRNA with sodA PCR accurately identify G sanguinis.
“Neutral and niche dynamics in a synthetic microbial community”
Authors: Cira NJ , Pearce MT , Quake SR 
Published: February 2017

AbstractEcologists debate the relative importance of niche versus neutral processes in understanding biodiversity1,2. This debate is especially pertinent to microbial communities, which play crucial roles in biogeochemical cycling3,4, food production5, industrial processes6,7, and human health and disease8. Here we created a synthetic microbial community using heritable genetic barcodes and tracked community composition over time across a range of experimental conditions. We show that a transition exists between the neutral and niche regimes, and, consistent with theory, the crossover point depends on factors including immigration, fitness, and population size. We find that diversity declined most rapidly at intermediate population sizes, which can be explained by a tradeoff between replacement by migration and duration of growth. We then ran an experiment where the community underwent abrupt or gradual changes in size, the outcome of which highlights that selecting the correct model is essential to managing diversity. Taken together these results emphasize the importance of including niche effects to obtain realistic models across a wide range of parameters, even in simple systems.
Improving the customer experience through consistency and effective service delivery in the United Kingdom public house sector
Authors: Andrews David , Turner Simon 
Published: February 2017

Purpose
The purpose of this paper is to ask if customer experiences in public houses (pubs) go wrong because of poor initial and subsequent training for front-line staff, while questioning if enough is being made of employee engagement and socialization as a means to improve consistency within the pub service encounter.

Design/methodology/approach
The study applies a critical review of the literature with a focus on the initial and subsequent training of front-line employees in the context of managed and entrepreneur-led pub-retailing operations.

Findings
The delivery and impact of a well-designed initial training programme may not only enhance long-term employee engagement and loyalty, but also provide competitive advantage for pub-retail operations through a more consistent service delivery. The paper questions the suitability of the approach currently being adopted within the sector and suggests that change is needed in order to ensure the longer-term survival of pub-retail businesses.

Practical implications
Can reliable and consistent customer experiences be delivered without a more progressive approach to the initial training and engagement of front-line employees?

Originality/value
While the importance of initial and subsequent training is widely accepted, the potential for its poor delivery has an almost predictable impact on many customer experiences. The paper recommends a review of the methods used by managed house and entrepreneurial (tenanted and leasehold) pub-retailing businesses to enhance employee socialization, engagement and loyalty to fuel the sector’s drive to generate greater competitive advantage.
All that glitters isn’t gold
Authors: Perrin Joy M. , Yang Le , Barba Shelley , Winkler Heidi 
Published: February 2017

Purpose
Digital collection assessment has focused mainly on evaluating systems, metadata and usability. While use evaluation is discussed in the literature, there are no standard criteria and methods for how to perform assessment on use effectively. This paper asserts that use statistics have complexities that prohibit meaningful interpretation and assessment. The authors aim to discover the problems inherent in the assessment of digital collection use statistics and propose solutions to address such issues.

Design/methodology/approach
This paper identifies and demonstrates five inherent problems with use statistics that need to be addressed when doing assessment for digital collections using the statistics of assessment tools on local digital repositories. The authors then propose solutions to resolve the problems that present themselves upon such analysis.

Findings
The authors identified five problems with digital collection use statistics. Problem one is the difficulty of distinguishing different kinds of internet traffic. Problem two is the lack of direct correlation of a digital item to its multiple URLs, so statistics from external web analytics tools are not ideal. Problem three is the analytics tools’ inherent bias in statistics that are counted only in the positive way. Problem four is the different interaction between digital collections with search engine indexing. Problem five is the evaluator’s bias toward simple growing statistics over time for surmising a positive use assessment. Because of these problems, statistics on digital collections do not properly measure a digital library’s value.

Practical implications
Findings highlight problems with current use measures and offer improvements.

Originality/value
This paper identifies five problems that need to be addressed before a meaningful assessment of digital collection use statistics can take place. The paper ends with a call for evaluators to try to solve or mitigate the stated problems for their digital collections in their own evaluations.
Developmental factors and drug use in young offenders
Authors: Madden Adele , Ireland Carol A. 
Published: February 2017

Purpose
Young offenders are known to have more chaotic experiences in childhood than non-offenders, and this impacts on their attachments, coping styles and early maladaptive schemas (EMS). The purpose of this paper is to explore the relationship between these factors and drug use.

Design/methodology/approach
This study used self-report questionnaires on a sample of 105 incarcerated young offenders.

Findings
Attachment styles did not differentiate drug users from non-drug users. Drug users were found to be no more likely than non-drug users to use avoidant coping styles. However, they were more likely to have emotional coping styles. Drug users had more EMS, and overall, those with insecure attachments had more EMS. Individuals with emotional coping styles scored higher than those with rational coping styles on several EMS. Those with emotional coping styles scored lower on the emotional inhibition EMS than those with rational coping styles.

Practical implications
The evidence presented has implications for the understanding of drug use in young offenders by: providing support to the model proposed by Young et al. (2003) regarding how insecure attachments can contribute to EMS; providing support for Crittenden’s (2008) model of attachment whereby problematic behaviours such as drug use can be a strategy the individual uses to protect themselves at times of threat or discomfort; highlighting the need for an integrated model of substance use in offenders which incorporates early experiences, attachments and EMS; and highlighting why substance use may become a coping strategy in young offenders and how to engage them to meet their needs in pro-social ways.

Originality/value
The study contributes to the understanding of attachment, coping and drug use in a young offender population. It sets foundations in the authors’ understanding of patterns of EMS in young drug users and highlights the need for an integrated model of substance use which incorporates early experiences, attachments and EMS.
Exploring the belief systems of domestic abuse victims: an exploratory study
Authors: Spruin Elizabeth , Baker Ria , Papadaki Ioanna , Franz Anke , Alleyne Emma 
Published: February 2017

Purpose
Support service provisions for domestic abuse victims have typically focussed on the immediate risk and etiological factors associated with abuse. Consequently, there is limited research exploring more persistent and pervasive factors involved in this cycle of abuse, such as subjective experiences and beliefs held by victims of domestic abuse. The purpose of this paper is to preliminary explore individual experience of domestic abuse including the belief systems of participants. Increasing our understanding of key factors and beliefs in the experience of domestic abuse could enable support services to create more long-term sustainable support for victims.

Design/methodology/approach
In total, 12 women with a history of domestic abuse participated in an exploratory interview about their general beliefs and thoughts surrounding their domestic abuse experience. Interviews were analysed using thematic analysis.

Findings
The thematic analysis identified four belief themes: personal responsibility, antisocial attitudes, environmental factors and negative attitudes towards police.

Practical implications
The paper highlights the value of understanding subjective, personalized experiences and beliefs of domestic abuse victims; identifies the importance of belief systems as potential treatment targets for domestic abuse victims; and acknowledges an avenue for more effective support provision for victims of domestic abuse.

Originality/value
This preliminary study offers new insights into the role of belief systems amongst a sample of domestically abused women. Understanding the significance of personalized, subjective experiences of domestic abuse victims is a step towards designing and implementing effective interventions. The findings further emphasize the need for more empirical research and theory development within the area of beliefs and domestic abuse victims.
The entrepreneurial university: an exploration of “value-creation” in a non-management department
Authors: Madichie Nnamdi O. , Gbadamosi Ayantunji 
Published: February 2017

PurposeThe purpose of this paper is to highlight the strategies undertaken by “entrepreneurial” universities to leverage their bottom-line especially in response to withdrawals of public funding. Internationalisation has been the most prominent from setting-up overseas branch campuses to aggressive recruitment drives for international students, and more recently, the launch of new programmes to attract a wider market.Design/methodology/approachBased on a documentary analysis, this study explores the future of curriculum development in entrepreneurial universities, using narratives around an “unconventional course” launch as a case illustration.FindingsThe findings reveal an interesting interaction of innovation, opportunity recognition, risk taking and pro-activeness at play within a university environment. The study also highlights how instructors have, in the past, based their syllabi on celebrities – from the Georgetown University to the University of South Carolina, University of Missouri and Rutgers University cutting across departments from English through sociology to Women’s and Gender Studies.Practical implicationsOverall this study captures the relationship between hip-hop artistry and poetry, as well as meeting the demands of society – societal impacts – not the least, bringing “street cred” into the classroom.Social implicationsThe case illustration of a course launch at the University of Missouri linking hip-hop artists to curriculum development and pedagogy, opens up the discourse on the future trajectory of teaching and learning in higher education, with its attendant social implications – not the least for life after graduation.Originality/valueThis study provides fresh insights into the entrepreneurial potential of universities in co-branded/marketing activities with the hip-hop industry.
Researchers as enablers of commercialization at an entrepreneurial university
Authors: Berggren Eva 
Published: February 2017

PurposeThe purpose of this paper is to explore and visualize alternative ways – how and by whom – that academic research can come into commercial use.Design/methodology/approachThis study in the Swedish context investigates one entrepreneurial university, Chalmers University of Technology. In total, 18 interviews were conducted about researchers’ views on commercialization and on how research comes into commercial use.FindingsFive propositions are advocated in relation to researchers’ role as enablers of others’ commercialization. The concept of “need for utilization” is introduced as the critical explanation for researchers’ readiness to transfer knowledge mainly via alumni to established companies.Practical implicationsThis study suggests that both universities and policy should acknowledge alternative ways of commercialization of academic research instead of putting all efforts on trying to transform unwilling academic researchers into entrepreneurs. One alternative is to foster ongoing contacts between researchers and alumni, who make commercial use of academic research in established firms.Originality/valueThis study furthers the knowledge about researchers’ individual motivation for commercialization, as driven by a “need for utilization.” By showing how researchers enable others commercialization, this study broadens the prevailing focus on researchers’ formation of university spin-offs as the essential output from entrepreneurial universities. The results also contribute to understanding the role of alumni in knowledge transfer to existing industry.
Expanding entrepreneurship education ecosystems
Authors: Belitski Maksim , Heron Keith 
Published: February 2017

Purpose
The creation of start-ups using knowledge provided by universities has been identified as an important source of knowledge spillover and regional economic development. Entrepreneurship ecosystems in education have become the most important and efficient mechanism of business community engagement and knowledge transfer within university-industry-government framework creating value to society and regional economy. The paper aims to discuss these issues.

Design/methodology/approach
This study undertakes in-depth synthesis of eclectic literature on entrepreneurship ecosystems and knowledge spillover of entrepreneurship, examining the critical success factors and enablers of entrepreneurship ecosystems in education.

Findings
This study proposes entrepreneurship education ecosystems as an alternative unit of analysis when it comes to considering the role of university-industry-government collaboration in knowledge commercialization. The authors recommend key entrepreneurship education ecosystem enablers for knowledge commercialization and engagement with entrepreneurial communities.

Originality/value
The authors propose a framework for the creation of an entrepreneurship education ecosystem as a unit of analysis when considering the role of university-industry-government collaboration. It requires different approaches to teaching, research and business outreach, some of which have not yet been discovered or yet need to be created.
Analyzing external environment factors affecting social enterprise development
Authors: Medina Munro Michelle , Belanger Charles 
Published: February 2017

Purpose
The purpose of this paper is to analyze how factors in the external environment affect social enterprise (SE) development in Canada. With the decline in government funding for non-profit organizations, SE development is gaining greater traction. SEs are businesses and can be analyzed with methods similar to those for traditional businesses. Just as the external environment is important for assessing the success of businesses, in this study, the authors examine the external environment related to SEs.

Design/methodology/approach
In this statistical analysis, the authors compared 62 factors across 33 census metropolitan areas (CMAs) in Canada while treating SE revenue as the dependent variable. Links between the dependent variable and the external environment were analyzed through correlation and regression tests. Publicly available revenue figures for non-profit SEs by CMAs were compared with a selection of external environment factors, including demographic information and health indicators, also organized by CMA, as published by Statistics Canada.

Findings
The analysis demonstrated that three of the factors displayed significant positive correlation and one resulted in a predictive value. Positive correlations were discovered between SE revenue per capita and three of the variables: university education, perceived health, very good or excellent and no religious affiliation. Only university education was found to have predictive value.

Originality/value
This study is the first to compare SE revenue and the external environment across Canada’s CMAs. The results show that factors in the external environment create conditions more conducive to SE development.