bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D status and cardiometabolic risk factors across latitudinal gradient in Iranian adults: National food and nutrition surveillance
Authors: Nikooyeh Bahareh , Abdollahi Zahra , Hajifaraji Majid , Alavi-majd Hamid , Salehi Forouzan , Yarparvar Amir Hossein , Neyestani Tirang R 
Published: April 2017

Background: This study aimed to evaluate the vitamin D status in an adult population across latitudinal gradient and to investigate its possible associations with certain cardiometabolic risk factors. Methods: A total of 1406 healthy subjects aged 19-60 years were randomly selected from six regions of Iran across latitudinal gradient from 29° N to 37.5° N. Anthropometric and biochemical assessments were performed. The combination of high body mass index (>25 kg/m2), low high-density lipoprotein cholesterol (< 40 mg/dl in males and < 50 mg/dl in females) and high triglycerides (> 150 mg/dl) was defined as cardiometabolic risk factors. Results: The mean concentration of serum 25-hydroxycalciferol (25(OH)D) was 26.8±17.7 nmol/l. There were no significant differences in the mean serum 25(OH)D levels among different latitudes. Undesirable vitamin D status (deficiency and insufficiency) was found in 90.7% of the subjects. After adjustment for age and gender, the association between weight status and serum 25(OH)D was significant ( p< 0.04, odds ratio:1.49; confidence interval: 1.01-2.19). The prevalence of cardiometabolic risk factors among the subjects with serum 25(OH)D less than 27.5 nmol/l was significantly higher than those with serum calcidiol concentrations above 27.5 nmol/l (13.3% vs. 10.0%, p = 0.033). Conclusion: Undesirable vitamin D status is highly prevalent among Iranian adults of both sexes irrespective of latitude and even in sunny regions. The occurrence of cardiometabolic risk factors was significantly higher in those subjects with circulating calcidiol concentrations below 27.5 nmol/l.
Global Spread of Pharmaceutical Patent Protection: Micro Evidence from the International Equivalents of Drug Patents in Japan
Authors: Okada Yoshimi , Nagaoka Sadao 
Published: April 2017

We investigate the global spread of pharmaceutical patent protection as acquired by firms, based on a novel global patent database for all significant medical drugs, including biologics, introduced in Japan. It gives us the propensity of filing and grant rate for each country for patents granted in Japan. The major findings of the study are as following. Both the filing propensity to and the grant rate of major Asian countries approached those of the OECD economies by the early 2000s for chemical substance inventions. However, substantial heterogeneity with respect to other drug inventions still exists, specifically, crystal, use, formulation or combination, suggesting significant future room for international harmonization of patent granting standards. We found clear evidence of policy impact on the spread of protection for the two largest non-OECD economies. The amendments to Patent Laws in China in 1993 had an immediate and significant impact on patent filing propensity to China (30 percentage points increase), before accession to the WTO in late 2001. Furthermore, India’s ‘mailbox application system’ had a substantial effect as filing propensity reached 80 per cent of the number of corresponding European patent applications around year 2000, prior to implementing the Trade-Related Aspects of Intellectual Property Rights for drug patents in 2005. Subject classification codes: O34, O38, K29
Preoperative risk factors for aneurysm sac expansion caused by type 2 endoleak after endovascular aneurysm repair
Authors: Morisaki Koichi , Yamaoka Terutoshi , Iwasa Kazuomi , Ohmine Takahiro , Guntani Atsushi 
Published: April 2017

Purpose The objective of this study was to investigate the preoperatively definable risk factors which predict the aneurysm sac expansion caused by persistent type 2 endoleak after endovascular aneurysm repair. Methods Between 2008 and 2014, retrospective analysis was performed to examine the predictive risk factors for aneurysm sac enlargement caused by persistent type 2 endoleak, which was defined as a continuous endoleak present for more than six months. Aneurysm sac expansion was diagnosed if the maximum transverse diameter increased by 5 mm or more compared with the preoperative measurement. Results During the study period, endovascular aneurysm repair was performed in 211 patients with abdominal aortic aneurysm and common iliac artery aneurysm. Sac enlargement for type 2 endoleaks was observed in 20 patients (9.5%). The presence of more than five patent lumbar arteries flowing into aneurysm sac in the preoperative computed tomography (hazard ratio, 3.37; 95% confidence interval, 1.24–10.8; p = 0.017) was a predictive factor for sac expansion caused by persistent type 2 endoleak on Cox regression analysis. The presence of a patent inferior mesenteric artery was not associated with the sac expansion caused by persistent type 2 endoleak. Conclusions The presence of more than five lumbar arteries flowing into the aneurysm sac was a preoperative risk factor for sac expansion caused by persistent type 2 endoleak.
Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model
Authors: Friedman James M. , Sennett Mackenzie L. , Bonadio Marcelo B. , Orji Kerry O. , Neuwirth Alexander L. , Keah Niobra , Carey James L. , Moutos Franklin T. , Estes Bradley T. , Guilak Farshid , Madry Henning , Mauck Robert L. , Dodge George R. 
Published: April 2017

ObjectiveTo test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model.MethodsFull thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor. Experimental endpoints were between 1 and 6 weeks. Micro–computed tomography and histology were used to assess samples.ResultsThe MIS approach was superior as the traditional approach caused medial condyle cartilage wear. One of 13 (7.7%) of scaffolds without fixation, 4 of 11 (36.3%) fibrin scaffolds, 1 of 4 (25%) of sutured scaffolds, and 9 of 9 (100%) of anchor-fixed scaffolds remained in place. Histology demonstrated tissue filling with some overgrowth of PCL scaffolds.ConclusionsOf the methods tested, the MIS approach coupled with subchondral anchor fixation provided the best scaffold retention in a mini-pig chondral defect model. This finding has implications for fixation strategies in future animal studies and potential future human use.
Controlling Abnormal Joint Movement Inhibits Response of Osteophyte Formation
Authors: Murata Kenji , Kokubun Takanori , Morishita Yuri , Onitsuka Katsuya , Fujiwara Shuhei , Nakajima Aya , Fujino Tsutomu , Takayanagi Kiyomi , Kanemura Naohiko 
Published: April 2017

Objective Osteoarthritis (OA) is induced by accumulated mechanical stress to joints; however, little has been reported regarding the cause among detailed mechanical stress on cartilage degeneration. This study investigated the influence of the control of abnormal joint movement induced by anterior cruciate ligament (ACL) injury in the articular cartilage. Design The animals were divided into 3 experimental groups: CAJM group ( n = 22: controlling abnormal joint movement), ACL-T group ( n = 22: ACL transection or knee anterior instability increased), and INTACT group ( n = 12: no surgery). After 2 and 4 weeks, the knees were harvested for digital microscopic observation, soft X-ray analysis, histological analysis, and synovial membrane molecular evaluation. Results The 4-week OARSI scores showed that cartilage degeneration was significantly inhibited in the CAJM group as compared with the ACL-T group ( P < 0.001). At 4 weeks, the osteophyte formation had also significantly increased in the ACL-T group ( P < 0.001). These results reflected the microscopic scoring and soft X-ray analysis findings at 4 weeks. Real-time synovial membrane polymerase chain reaction analysis for evaluation of the osteophyte formation–associated factors showed that the mRNA expression of BMP-2 and VEGF in the ACL-T group had significantly increased after 2 weeks. Conclusions Typically, abnormal mechanical stress induces osteophyte formation; however, our results demonstrated that CAJM group inhibited osteophyte formation. Therefore, controlling abnormal joint movement may be a beneficial precautionary measure for OA progression in the future.
Self-evaluation of tobacco exposure by allied health students in a community college setting
Authors: Geiser Fiona , Much Meredith , Beyer Karen 
Published: April 2017

Objective: Tobacco education is among the initiatives encouraged for health professionals to help them appreciate the significance of addressing tobacco use among their patients. In this pilot study, a nicotine biomarker (cotinine) study was introduced to an applied microbiology course required of all allied health students. Participants assessed their own smoking status in the previous 24 h using a two-dimensional experimental design of a questionnaire and rapid urinary cotinine immunoassay. The study goals were >90% participation of the home-administered assay and high correlation of the results to cotinine standards. Allied health students (medical assistants, respiratory therapists, surgical technicians) were selected as the initial test group. Methods: The study was initiated 10 months after the college became 100% tobacco free. Participants were initially trained on the use and interpretation of the rapid cotinine test using three cotinine standards (0, 400, and 2000 ng/mL urine). Participants subsequently tested their own first-morning urine sample at home and then answered a questionnaire about their tobacco smoke (and/or nicotine) exposure in the previous 24-h period. Results: The cotinine laboratory was offered to a total of 161 students (88% female) over 24 months. Participants who reported no exposure to a nicotine product in any venue made up 55% of the group. Daily smokers made up 17% of the study participants as confirmed by their elevated cotinine levels (greater than 100 ng/mL urine). The remaining participants (28%) either resided with smokers and/or rode in an automobile with an individual smoking in the previous 24 h. Their cotinine levels were moderately elevated in some cases, particularly if they had ridden in a car with a smoker. Conclusion: The pilot study met our objectives of >90% participation and high correlation of urinary cotinine levels with questionnaire self-reports.
Marathoning with myotonic dystrophy type 2 (proximal myotonic myopathy) and leukopenia
Authors: Finsterer Josef , Safoschnik Georg , Witsch-Baumgartner Martina 
Published: April 2017

Objectives: A mild, slowly progressive course of proximal myotonic myopathy, also known as myotonic dystrophy type 2, over years allowing the patient to continue with extreme sport activity, has been only rarely reported. Methods: Case report. Results: The patient is a 54-year-old female sport teacher who developed myotonia of the distal upper limbs at the age of 32 years. Over the following 22 years, myotonia spreaded to the entire musculature. Myotonia did not prevent her from doing her job and from marathoning and improved with continuous exercise. Additionally, she had developed hypothyroidism, ovarial cysts, incipient cataract, motor neuropathy, hepatopathy, leukopenia, and mild hyper-CK-emia. A heterozygous CCTG-repeat expansion of 500–9500 was found in the CNBP/ZNF9 gene. At the age of 54 years, she was still performing sport, without presenting with myotonia on clinical examination or having developed other typical manifestations of proximal myotonic myopathy. Conclusions: This case shows that proximal myotonic myopathy may take a mild course over at least 22 years, that proximal myotonic myopathy with mild myotonia may allow a patient to continue strenuous sport activity, and that continuous physical activity may contribute to the mild course of the disease.
Challenges and opportunities in evaluating a digital sexual health intervention in a clinic setting: Staff and patient views
Authors: Bailey JV , Tomlinson N , Hobbs LJ , Webster R 
Published: April 2017

Objectives The aim of the study was to gather the views of sexual health clinic staff and male clinic users regarding digital sexual health promotion and online trial procedures. Methods The Men’s Safer Sex website was offered on tablet computers to men in the waiting rooms of three sexual health clinics, in a feasibility online randomised controlled trial (RCT). Interviews were conducted with 11 men who had participated in the trial and with nine clinic staff, to explore their views of the website and views of the online trial. Interviews were audio-recorded and transcribed, and we conducted a thematic analysis of interviews and of 281 free text comments from the online RCT outcome questionnaires. Results Clinic users and staff felt that digital interventions such as the Men’s Safer Sex website are useful, especially if NHS endorsed. Pre-appointment waiting time presents a good opportunity for intervention but clinic users and staff felt that a website should supplement rather than replace face-to-face healthcare. The RCT procedures fitted well around clinical activities, but men did not self-direct to the tablet computers. Staff were more concerned about consent and confidentiality than clinic users, and staff and patients were frustrated by multiple technical problems. The trial outcome questionnaire was thought-provoking and could constitute an intervention in itself. Participants felt that clinics would need to promote a digital intervention and/or offer the site routinely to promote engagement. Conclusion Digital interventions could usefully supplement in-person sexual health care, but there are important obstacles in terms of IT access in NHS settings, and in promoting engagement.
High-Risk Subgroup Membership Is a Predictor of 30-Day Morbidity Following Anterior Lumbar Fusion
Authors: Bronheim Rachel S. , Kim Jun S. , Di Capua John , Lee Nathan J. , Kothari Parth , Somani Sulaiman , Phan Kevin , Cho Samuel K. 
Published: April 2017

Study Design: Retrospective cohort study. Objective: To determine if membership in a high-risk subgroup is predictive of morbidity and mortality following anterior lumbar fusion (ALF). Methods: The American College of Surgeons National Surgical Quality Improvement Program database was utilized to identify patients undergoing ALF between 2010 and 2014. Multivariate analysis was utilized to identify high-risk subgroup membership as an independent predictor of postoperative complications. Results: Members of the elderly (≥65 years) (OR = 1.3, P = .02) and non-Caucasian (black, Hispanic, other) (OR = 1.7, P < .0001) subgroups were at greater risk for a LOS ≥5 days. Obese patients (≥30 kg/m2 ) were at greater risk for an operative time ≥4 hours (OR = 1.3, P = .005), and wound complications (OR = 1.8, P = .024) compared with nonobese patients. Emergent procedures had a significantly increased risk for LOS ≥5 days (OR = 4.9, P = .021), sepsis (OR = 14.8, P = .018), and reoperation (OR = 13.4, P < .0001) compared with nonemergent procedures. Disseminated cancer was an independent risk factor for operative time ≥4 hours (OR = 8.4, P < .0001), LOS ≥5 days (OR = 15.2, P < .0001), pulmonary complications (OR = 7.4, P = .019), and postoperative blood transfusion (OR = 3.1, P = .040). Conclusions: High-risk subgroup membership is an independent risk factor for morbidity following ALF. These groups should be targets for aggressive preoperative optimization, and quality improvement initiatives.
A Preliminary Algorithm Using Spine Measurement Software to Predict Sagittal Alignment Following Pedicle Subtraction Osteotomy
Authors: Merrill Robert K. , Kim Jun S. , Leven Dante M. , Meaike Joshua J. , Kim Joung Heon , Cho Samuel K. 
Published: April 2017

Study Design: Retrospective case series. Objective: To evaluate if spine measurement software can simulate sagittal alignment following pedicle subtraction osteotomy (PSO). Methods: We retrospectively reviewed consecutive adult spinal deformity patients who underwent lumbar PSO. Sagittal measurements were performed on preoperative lateral, standing radiographs. Sagittal measurements after simulated PSO were compared to actual postoperative measurements. A regression equation was developed using cases 1-7 to determine the amount of manual rotation required of each film to match the simulated sagittal vertical axis (SVA) to the actual postoperative SVA. The equation was then applied to cases 8-13. Results: For all 13 cases, the spine software accurately simulated lumbar lordosis, pelvic incidence lumbar lordosis mismatch, and T1 pelvic angle, with no significant differences between actual and simulated measurements. The pelvic tilt (PT), sacral slope (SS), thoracolumbar alignment (TL), thoracic kyphosis (TK), T9 spino-pelvic inclination (T9SPi), T1 spino-pelvic inclination (T1SPi), and SVA were inaccurately simulated. The PT, SS, T9SPi, T1SPi, and SVA all change with manual rotation of the film, and by using the regression equation developed with cases 1-7, we were able to improve the accuracy and decrease the variability of the simulated PT, SS, T9SPi, T1SPi, and SVA for cases 8-13. Conclusions: Dedicated spine measurement software can accurately simulate certain sagittal measurements, such as LL, PI-LL, and TPA, following PSO. A number of measurements, including PT, SS, TL, TK, T9SPi, T1SPi, and SVA were inaccurately simulated. Our preliminary algorithm improved the accuracy and decreased the variability of certain measurements, but requires future prospective studies for further validation.
Resource-loaded piping spool fabrication scheduling: material-supply-driven optimization
Authors: Liu Jing , Soleimanifar Meimanat , Lu Ming 
Published: April 2017

Abstract
Background
As offsite prefabrication and modular construction continue to gain momentum into the future, material supply chain becomes increasingly complex for modern construction projects. Pre-engineered material supply presents itself as a driver for planning crew installation operations on site that involve skilled labor and heavy equipment.

Methods
This paper proposes a framework for implementing the material-supply-driven project planning and control optimization approach to deal with material delays that take place at the piping spool fabrication shop. Design drawings, contract deadlines, resources availability and material supply patterns are extracted from a real oil and gas expansion project to validate the proposed implementation methodology.

Results
An interactive Gantt chart with information on activity start time, duration, and allocated resources is generated to visualize the optimization outcome. In connection with the resource-constrained schedule, material supply-demand patterns over project duration are also visualized.

Conclusions
These two forms of visualizations provide insightful decision-making support in coping with material delay while fulfilling project objectives. Ultimately, material-supply driven crew job schedules in correspondence with particular objectives and implementation strategies can be generated, ready to guide project execution.
Reservoir-oriented wave-equation-based seismic amplitude variation with offset inversion
Authors: Gisolf Dries , Haffinger Peter R. , Doulgeris Panos 
Published: April 2017

Wave-equation-based amplitude-variation-with-offset (AVO) inversion solves the full elastic wave equation, for the properties as well as the total wavefield in the object domain, from a set of observations. The relationship between the data and the property set to invert for is essentially nonlinear. This makes wave-equation-based inversion a nonlinear process. One way of visualizing this nonlinearity is by noting that all internal multiple scattering and mode conversions, as well as traveltime differences between the real medium and the background medium, are accounted for by the wave equation. We have developed an iterative solution to this nonlinear inversion problem that seems less likely to be trapped in local minima. The surface recorded data are preconditioned to be more representative for the target interval, by redatuming, or migration. The starting model for the inversion is a very smooth (0–4 Hz) background model constructed from well data. Depending on the data quality, the nonlinear inversion may even update the background model, leading to a broadband solution. Because we are dealing with the elastic wave equation and not a linearized data model in terms of primary reflections, the inversion solves directly for the parameters defining the wave equation: the compressibility (1/bulk modulus) and the shear compliance (1/shear modulus). These parameters are much more directly representative for hydrocarbon saturation, porosity, and lithology, than derived properties such as acoustic and shear impedance that logically follow from the linearized reflectivity model. Because of the strongly nonlinear character of time-lapse effects, wave-equation based AVO inversion is particularly suitable for time-lapse inversion. Our method is presented and illustrated with some synthetic data and three real data case studies.
Pore characteristics of lacustrine mudstones from the Cretaceous Qingshankou Formation, Songliao Basin
Authors: Wang Min , Lu Shuangfang , Huang Wenbiao , Liu Wei 
Published: April 2017

Cretaceous Qingshankou ([Formula: see text]) mudstone of lacustrine origin is the major source rock for conventional hydrocarbon currently being produced in the Daqing and Jilin oilfields of the Songliao Basin, which is one of the largest continental basins in the world. Therefore, elucidating the geochemical and petrological characteristics of the [Formula: see text] mudstone is important to help determine its quality as an economically viable source for shale oil production. In our study, eight dark mudstone core samples from the [Formula: see text] formation were subjected to total organic carbon (TOC), Rock-Eval pyrolysis, X-ray diffraction, scanning electron microscopy (SEM), field emission SEM (FE-SEM), and low-pressure [Formula: see text] gas adsorption (LPGA-[Formula: see text]) experiments. Geochemical and petrological analysis results indicated the presence of a high TOC content, which originated mainly from alginate and some plant-derived organic matter, whereas bitumen was frequently present in mudstones with thermal maturity in the oil-generation stage. The [Formula: see text] mudstones were comprised mainly of clay minerals, followed by quartz, feldspar, and carbonates. The LPGA-[Formula: see text] experiments revealed the presence of nanoscale slit-shaped pores, and the contribution from mesopores to the total pore volume was the highest in most of the samples. The average pore diameters (APDs) of the mudstone samples were all smaller than 20 nm (4.36–17.79 nm). We determined that there was a clear positive correlation between the APD and the free oil content; however, there were no clear correlations between the APDs and the quartz, carbonate, and TOC contents. FEM studies revealed the presence of intergranular pores with widths of approximately 10 μm, micron-level autogenetic organic matter pores within spores, organic matter pores caused by the hydrocarbon generation effect within organic matter or clay-organic complexes, and intraparticle pores within clays or pyrite framboids. The microlevel intergranular pores might play an important role in shale oil accumulation from source rock of lacustrine origin.