bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naringin Affects Caspase-3, IL-1β, and HIF-1α Levels in Experimental Kidney Ischemia-Reperfusion in Rats
Authors: Danis Esra Gulsum , Acar Gozde , Dasdelen Dervis , Solmaz Merve , Mogulkoc Rasim , Baltaci Abdulkerim Kasim 
Published: September 2024

Background:
Microvascular dysfunction develops in tissues after Ischemia-Reperfusion (IR). The
current study aimed to determine the effect of naringin supplementation on kidney caspase-3, IL-1β, and
HIF-1α levels and kidney histology in rats undergoing unilateral nephrectomy and kidney-ischemia reperfusion.

Methods:
The study was conducted on 8-12 weeks old 40 Wistar-type male rats. Experimental renal ischemia-
reperfusion and unilateral nephrectomy were performed under general anesthesia in rats. Experimental
groups were formed as follows: 1-Control group, 2-Sham control + Vehicle group, 3- Renal ischemia-reperfusion
(Renal I+R) + Vehicle group, 4-Renal I+R + Naringin (50 mg/kg/day) group (3 days application) group,
5-Renal I+R + Naringin (100 mg/kg/day) group (3 days supplementation). Nephrectomy in the left kidneys
and the ischemia for 45 minutes and reperfusion in the right kidneys followed by 72 hours of reperfusion.
Naringin was administered intraperitoneally at the beginning of the reperfusion, 24 hours and 48 hours later.
At the end of the experiments, blood was first taken from the heart in animals under general anesthesia. Then,
the animals were killed by cervical dislocation, and kidney tissue samples were taken. Tissues were evaluated
for caspase-3, IL-1β, and HIF-1α as well as histologically.

Results:
As a result of ischemia in kidney tissues, HIF-1α decreased, while caspase-3 and IL-1β increased. IR
also caused damage to the kidney tissue. However, naringin supplementation corrected the deterioration to a
certain extent.

Conclusion:
The results of the study showed that naringin may have protective effects on kidney damage due
to anti-inflammatory and antiapoptosis mechanisms caused by unilateral nephrectomy and IR in rats.
Laryngeal Mask for Minimally-invasive Surfactant Administration: A Narrative Review
Authors: De Bernardo Giuseppe , Crisci Valeria , Centanni Fabio , Giordano Maurizio , Perrone Serafina , Buonocore Giuseppe , Mandato Claudia 
Published: September 2024

:
The cornerstone of treatment for respiratory distress syndrome in preterm infants is surfactant
administration, traditionally performed through an invasive procedure involving tracheal intubation
and mechanical ventilation. Consequently, there has been a growing interest in exploring
less invasive methods of surfactant delivery to mitigate the associated risks. Currently, several
techniques are under evaluation, including intratracheal instillation using a thin catheter, aerosolized
or nebulized administration, and guided administration by supraglottic airway devices. One
such method is surfactant administration through laryngeal or supraglottic airway, which involves
placing a laryngeal mask without the need for laryngoscopy and administering surfactant through
the device. The simplicity of laryngeal mask insertion could potentially streamline the surfactant
delivery process, eliminating the necessity for advanced skills. This narrative review aimed to assess
the current evidence in the literature regarding the benefits and risks associated with surfactant
administration through a laryngeal supraglottic airway.
Experimental and Fe Numerical Analysis Of Rc Shear Walls Retrofitted Using Cfrp and Steel Plates
Authors: Almassri Belal 
Published: September 2024

Introduction
Shear walls are recognized to be one of the main structural systems that resist lateral loads such as wind and earthquakes. This paper presents some advanced experimental and finite element FE analyses performed on five shear wall samples; four specimens were retrofitted using two different techniques.

Methods
The experimental program presents five specimens retrofitted using both CFRP and an external steel plate. The debonding of CFRP was the dominant mode of failure for the first two tested shear walls retrofitted with CFRP, so adding an external steel plate was an available solution that was conducted to increase the load capacity of the remaining specimens. A 3D finite element FE model was created using the commercial software Abaqus. This paper introduces a new and original hybrid strengthening of the shear walls (using CFRP and steel plates), which has not been studied before in the literature, and also shows some advanced features to simulate the CFRP attachment to the concrete layer to capture both the load capacity and the debonding failure, which was observed in the experimental results.

Results
The FE results were in good agreement with the experimental results for all tested specimens.

Conclusion
The retrofitted shear walls using CFRP and steel plate recovered almost 38% of the shear capacity of the control specimen.
The Recovery of a Pregnant Woman Infected with the Mutated Coronavirus: A Case Report from the Shahid Mostafa Khomeini Hospital of Ilam
Authors: Ghaysouri Abas , Rashidian Tayebeh , Balavandi Firoz , Feizi Jalil , Tavan Hamed 
Published: September 2024

Introduction:
The mutated strain of the novel coronavirus has spread in Ilam. In this case
report, we have described the recovery of a pregnant woman infected with the mutated coronavirus,
admitted to the Shahid Mostafa Khomeini Hospital of Ilam.

Case Presentation:
A 34-year-old pregnant woman was initially admitted to the coronavirus ward
and then intubated due to hypoxia. She was transferred to the obstetrics and gynecology ward for
delivery and then returned to the coronavirus ward. After three days, she was extubated and finally
discharged.

Conclusion:
With a quick diagnosis of coronavirus, the chances of survival and recovery can be
significantly increased among those affected. All people who present with flu-like symptoms during
the coronavirus epidemic, if it arises in the future, should be considered to be infected with the mutated
coronavirus and timely receive treatments and supportive measures. Furthermore, they and their
family members should be screened with the tests able to detect the mutated strain of the coronavirus.
Perempuan dan budaya kemiskinan penerima Program Keluarga Harapan
Authors: Sari Rosnida , Solikah Mar'atus 
Published: September 2024

Penelitian ini mengkaji budaya kemiskinan pada perempuan penerima Program Keluarga Harapan (PKH) di Desa Mronjo dengan menggunakan analisis Teori Budaya Kemiskinan dari Oscar Lewis. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologis, penentuan informan menggunakan teknik purposive sampling. Terdapat data sekunder diperoleh dari internet dan buku serta data primer diperoleh melalui observasi, wawancara semi terstruktur, dan dokumentasi. Keabsahan data menggunakan teknik triangulasi data, sedangkan analisis data mengacu pada analisis data menurut Miles dan Huberman. Wujud budaya kemiskinannya yaitu budaya ketergantungan terhadap bantuan sosial PKH, berutang, budaya anak harus membantu orang tua, istri sebagai pendukung utama perekonomian keluarga, dan pola pikir menerima kemiskinan sebagai takdir.This research examines the culture of poverty among women who receive the Family Hope Program (PKH) in Mronjo Village using Oscar Lewis's Cultural Theory of Poverty analysis. This research uses a qualitative method with a phenomenological approach, determining informants using a purposive sampling technique. There is secondary data obtained from the internet and books and primary data obtained through observation, semi-structured interviews and documentation. Data validity uses data triangulation techniques, while data analysis refers to data analysis according to Miles and Huberman. The forms of the culture of poverty are the culture of dependence on PKH social assistance, debt, the culture of children having to help their parents, the wife as the main supporter of the family economy, and the mindset of accepting poverty as destiny.
Pendidikan seks dan kesehatan repoduksi di Lapas khusus anak Gunung Kidul, Yogyakarta
Authors: Lianita Erika Indah Mey , Syahrul S , Wardana Amika 
Published: September 2024

Pendidikan Seks da Kesehatan reproduksi sangat penting dan khususnya bagi kelompok remaja rentan. Pandangan ini mendorong Youth Forum Gunung Kidul menyelenggarakan pendidikan seks dan kesehatan reproduksi kepada remaja Lembaga Pemasyarakatn Khusus Anak (LPKA) Kelas II Gunung Kidul, Yogyakarta. Dengan melakukan wawancara kualitatif melibatkan pengurus dan sukarelawan Youth Forum, Penelitian mendalami dan mendokumentasikan program dan kegiatan pendidikan seks dan kesehatan reproduksi bagi anak binaan LPKA Kelas II Gunung Kidul Yogyakarta. Hasil enelitian menunjukan bahwa 1) Youth Forum Gunung Kidul berperan sebagai Agen Sosialisasi 2) Youth Forum sebagai Media Komunikasi Stakeholder 3) Youth Forum sebagai pendamping Andik Pas 4) Youth Forum memberikan pedoman kepada Andik Pas 5) Youth Forum meningkatkan keterampilan sukarelawan bekerja dengan remaja-remaja rentan dengan penuh perhatian. Sex education and reproductive health are very important, especially for vulnerable groups of teenagers. This view prompted the Gunung Kidul Youth Forum to organize sex and reproductive health education for teenagers at the Class II Special Children's Correctional Institution (LPKA) Gunung Kidul, Yogyakarta. By conducting qualitative interviews involving Youth Forum administrators and volunteers, the research explored and documented sex education and reproductive health programs and activities for children assisted by LPKA Class II Gunung Kidul Yogyakarta. The research results show that 1) the Gunung Kidul Youth Forum acts as a Socialization Agent 2) the Youth Forum as a Communication Media for Stakeholders 3) the Youth Forum as a companion for Andik Pas 4) the Youth Forum provides guidance to Andik Pas 5) the Youth Forum improves the skills of volunteers working with teenagers vulnerable teenagers with great care.
Wisata budaya dan kuliner pasar keramat Pacet di media sosial
Authors: Rohma Nur Faizatur 
Published: September 2024

Penelitian menelaah pasar keramat Pacet, yang merupakan salah satu pasar tradisional di Jawa Timur, beradaptasi dengan perkembangan zaman dan menjaga kelestarian wisata budaya dan kuliner tradisionalnya. Media sosial berperan dan digunakan sebagai sarana promosi untuk menarik minat pengunjung dan meningkatkan kesejahteraan para pedagang. Dengen pendekatan kualitatif berdasar data dari wawancara, observasi dan dokumentasi, penelitian mengungkap proses pelestarian pasar keramat Pacet. Hasil penelitian menyatakan bahwa 1) pasar keramat memiliki ciri khas dan keunikan tersendiri yang bisa menjadi daya tarik wisata dan 2) media sosial menjadi salah satu faktor penting dalam mempromosikan wisata budaya dan kuliner tradisional yang cukup efektif dan menyasar banyak audien.The research examines the Pacet sacred market, which is one of the traditional markets in East Java, adapting to the times and preserving its cultural tourism and traditional culinary delights. Social media plays a role and is used as a promotional tool to attract visitor interest and improve the welfare of traders. Using a qualitative approach based on data from interviews, observation and documentation, the research reveals the process of preserving Pacet's sacred market. The research results state that 1) sacred markets have their own characteristics and uniqueness which can become a tourist attraction and 2) social media is an important factor in promoting traditional cultural and culinary tourism which is quite effective and targets many audiences.
Strategi Pemasaran dalam Meningkatkan Tingkat Hunian Kamar Hotel pada Masa Pandemi Covid-19
Authors: Septiawan I Kadek Yudik , Suwintari I Gusti Ayu Eka , Purnantara I Made Hadi 
Published: September 2024

Penelitian ini membahas strategi pemasaran di RV Hotel by MaxOne Gianyar dalam meningkatkan tingkat hunian kamar hotel dalam masa pandemi Covid-19 dengan tujuan untuk mengetahui potensi internal dan eksternal, dan untuk mengetahui strategi alternatif yang dapat diterapkan di RV Hotel by MaxOne Gianyar. Teknik pengumpulan data dalam penelitian ini adalah dengan melakukan wawancara, observasi, dokumentasi, dan juga penyebaran kuesioner kepada 3 responden. Teknik analisis data yang digunakan yaitu deskriptif kualitatif berupa bauran pemasaran 4P, IFAS- EFAS dan analisis SWOT. Data primer diperoleh dari hasil wawancara, pemberian bobot dan rating untuk faktor-faktor IFAS, EFAS, sedangkan data sekunder diperoleh dari gambaran umum profil hotel dan dokumen tertulis dari RV Hotel by MaxOne Gianyar. Hasil penelitian dengan analisis SWOT didapat posisi RV Hotel by MaxOne Gianyar berada pada kuadran II, yakni menggunakan kekuatan untuk memanfaatkan peluang jangka panjang dengan cara strategi diversifikasi (produk/jasa). Dengan demikian, strategi yang dapat dilakukan RV Hotel by MaxOne Gianyar adalah dengan mengantisipasi ancaman eksternal yang dimiliki perusahaan dan memanfaatkan kekuatan perusahaan dari segi internal.

This study discusses the marketing strategy at RV Hotel by MaxOne Gianyar in increasing the occupancy rate of hotel rooms during the Covid-19 pandemic to know the internal and external potential and find alternative strategies that can be applied at RV Hotel by MaxOne Gianyar. Data collection techniques in this study were by conducting interviews, observation, documentation, and also distributing questionnaires to 3 respondents. The data analysis technique used is descriptive qualitative in the form of a 4P marketing mix, IFAS-EFAS, and SWOT analysis. Primary data were obtained from interviews, giving weights and ratings for IFAS and EFAS factors, while secondary data was obtained from an overview of hotel profiles and written documents from RV Hotel by MaxOne Gianyar. The results of the study using a SWOT analysis showed that the position of RV Hotel by MaxOne Gianyar was in quadrant II, namely using strength to take advantage of long-term opportunities using a diversification strategy (product/service). Thus, the strategy that can be carried out by RV Hotel by MaxOne Gianyar is to anticipate external threats owned by the company and take advantage of the company's strengths from an internal perspective.
Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors: Sprinkles Jessica K. , Lulla Anju , Hullings Autumn G. , Trujillo-Gonzalez Isis , Klatt Kevin C. , Jacobs David R. , Shah Ravi V. , Murthy Venkatesh L. , Howard Annie Green , Gordon-Larsen Penny , Meyer Katie A. 
Published: September 2024

OBJECTIVE
The potential for choline metabolism to influence the development of diabetes has received increased attention. Previous studies on circulating choline metabolites and incident diabetes have been conducted in samples of older adults, often with a high prevalence of risk factors.

RESEARCH DESIGN AND METHODS
Participants were from year 15 of follow-up (2000-2001) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 3,133, aged 33–45 years) with plasma choline metabolite (choline, betaine, and trimethylamine N-oxide [TMAO]) data. We quantified associations between choline metabolites and 15-year risk of incident diabetes (n = 387) among participants free of diabetes at baseline using Cox proportional hazards regression models adjusted for sociodemographics, health behaviors, and clinical variables.

RESULTS
Betaine was inversely associated with 15-year risk of incident diabetes (hazard ratio 0.76 [95% CI 0.67, 0.88] per 1-SD unit betaine), and TMAO was positively associated with 15-year risk of incident diabetes (1.11 [1.01, 1.22] per 1-SD unit). Choline was not significantly associated with 15-year risk of incident diabetes (1.05 [0.94, 1.16] per 1-SD).

CONCLUSIONS
Our findings are consistent with other published literature supporting a role for choline metabolism in diabetes. Our study extends the current literature by analyzing a racially diverse population-based cohort of early middle-aged individuals in whom preventive activities may be most relevant.
Behind the Hammer's Swing: Work Fatigue Among Traditional Stone Breakers in the Coastal Region of the Selayar Islands, Indonesia
Authors: Maharja Rizky , Tajuddin Tajuddin , Rahmansyah Sitti Fatimah , Kessi Andi Tenriola Fitri , Juliani Arni , Maharja Riadnin 
Published: September 2024

The work of stone breakers involves heavy and repetitive physical activity, which can increase the risk of injuries and health problems, one of which is work fatigue. Before work fatigue becomes more severe, it is essential to identify its causes. This study aims to analyze work fatigue and the factors that influence it. The study uses an observational analytic approach with a total of 50 respondents. The variables measured include age, length of work, years of service, workload, total sleep time, and work fatigue. Data collection was carried out through questionnaires and specific workload observations. The results of the study indicate that 25 people (50%) experienced high work fatigue. Further analysis showed that age (p-value = 0.020) and gender (p-value = 0.001) significantly influenced work fatigue. The results also showed that there was no significant effect of length of work (p-value = 0.140), years of service (p-value = 0.27), workload (p-value = 0.258), and total sleep time (p-value = 0.401) on work fatigue. This study concludes that work fatigue among traditional stone breakers is influenced by age and gender. Interventions are needed to reduce work fatigue through adjustments to the work environment and rest periods. This study reinforces the understanding of Q.S. Al-Baqarah/2:286, which emphasizes that every individual has limitations. The fatigue experienced is proof that the human body has limits and needs adequate rest to function optimally.
Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review
Authors: Doloking Haeria , Lallo Subehan , Manggau Marianti A , Rifai Yusnita 
Published: September 2024

Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants. Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.
Studi Farmakovigilans Penggunaan Obat Antiretriviral di Puskesmas Semarang
Authors: Lestari Asih Puji , Meki Pranata  
Published: September 2024

Kasus epidemi HIV di Indonesia pada tahun 2015 jumlah penderita yang terinfeksi HIV sebanyak 30.935 jiwa hingga tahun 2019 meningkat sebanyak 50.282 kasus baru. Pemberian Anti Retroviral Therapy (ART) memiliki dampak interaksi dan efek samping obat dalam jangka waktu yang lama. Meningkatnya efek samping obat dipengaruhi adanya perubahan mitokondria yang mengalami disfungsi serebrovaskular dan metabolism obat yang besar oleh enzim golongan sitokrom P450. Tujuan Penelitian yaitu untuk mengetahui gambaran dan kejadian reaksi obat yang tidak diinginkan pada pasien yang diberikan resep obat antiretroviral di puskesmas. Jenis penelitian ini merupakan penelitian observasional deskriptif, pengambilan data dilakukan secara prospektif pada pasien yang menerima obat HIV di Puskesmas. Populasi penelitian ini berjumlah 10 pasien yang telah memenuhi kriteria inklusi dan ekslusi. Teknik pengambilan sampel dalam penelitian ini adalah quota sampling dengan instrumen penelitian berupa lembar wawancara ROTD yang diambil dari algoritma Naranjo. Hasil penelitian menunjukkan bahwa penggunaan obat antiretroviral (ARV) dapat menimbulkan reaksi obat yang tidak diinginkan (ROTD) seperti mual, muntah, pusing (vertigo) pada 10 pasien dan masuk kategori probable sebesar 70% dan possible sebesar 30%.

Kata kunci: Farmakovigilans, Antiretroviral (ARV), Reaksi obat yang tidak diinginkan (ROTD)
Pengaruh Penggunaan Pelarut terhadap Skrining Fitokimia dan Profil Kromatografi Lapis Tipis (KLT) Ekstrak Daun Tobo-Tobo (Ficus septica Burm. F)
Authors: Mukhriani Mukhriani , Nur Azizah Syahrana  , Nursyamsi Dhuha  , Dwi Ariqoh Ridwan  
Published: September 2024

Pendahuluan: Penelitian Pengaruh Penggunaan Pelarut terhadap Skrining Fitokimia Dan Profil Kromatografi Lapis Tipis (KLT) Ekstrak Daun Tobo-Tobo (Ficus septica Burm. F). Tujuan daam penelitian ini adalah mengetahui kandungan Ficus septica Burm. F dengan Kromatografi Lapis Tipis (KLT). Metode: Pada penelitian ini dilakukan ekstraksi secara maserasi dengan pelarut air, etanol 96%, etil asetat, dan n-heksan. Profil fitokimia dilakukan untuk mengidentifikasi golongan senyawa alkaloid, flavonoid, tanin, saponin, steroid dan triterpenoid dengan KLT. Hasil: Adapun hasil yang didapatkan dari skrining fitokimia dan kromatografi lapis tipis menunjukkan kandungan senyawa bioaktif dalam ekstrak air adalah alkaloid, flavonoid, dan saponin, ekstrak etanol 96% adalah flavonoid, saponin, tanin, triterpenoid, ekstrak etil asetat adalah tanin, sedangkan ekstrak n-heksan tidak ditemukan kandungan senyawa yang diteliti. Identifikasi alkaloid dengan uji KLT pada ekstrak etanol 96% dengan nilai Rf 0,23, 0,43, 0,03 dan 0,25. Identifikasi flavonoid pada ekstrak etanol 96% dengan nilai Rf 0,2 dan 0,38, sedangkan ekstrak etil asetat dengan nilai Rf 0,38 dan 0,49. Identifikasi tanin pada ekstrak etil asetat dengan nilai Rf 0,63, sedangkan pada ekstrak n-heksan dengan nilai Rf 0,25, 0,58, dan 0,69. Identifikasi senyawa triterpenoid pada ekstrak etanol 96% dengan nilai Rf 0,58, 0,23 dan 0,4, pada ekstrak etil asetat dengan nilai Rf 0,63 dan 0,67, sedangkan pada ekstrak n-heksan dengan nilai Rf 0,18, 0,52, dan 0,65. Kesimpulan: Penggunaan pelarut yang berbeda dapat mempengarahui optimalnya penarikan senyawa metabolit sekunder pada daun tobo- tobo (Ficus septica Burm. F).
Kata kunci: Ekstraksi, Skrining Fitokimia, KLT, Pelarut