bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catabolic Effects of Human PTH (1–34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism
Authors: Siddiqui Jawed A. , Johnson Joshua , Le Henaff Carole , Bitel Claudine L. , Tamasi Joseph A. , Partridge Nicola C. 
Published: November 2017

AbstractThe bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH’s anabolic effects on bone. To determine its role in PTH’s catabolic effects, we continuously infused female wild-type (WT) and MCP-1−/− mice with hPTH or vehicle. Microcomputed tomography (µCT) analysis of cortical bone showed that hPTH-infusion induced significant bone loss in WT mice. Further, μCT analysis of trabecular bone revealed that, compared with the vehicle-treated group, the PTH-treated WT mice had reduced trabecular thickness and trabecular number. Notably, MCP-1−/− mice were protected against PTH-induced cortical and trabecular bone loss as well as from increases in serum CTX (C-terminal crosslinking telopeptide of type I collagen) and TRACP-5b (tartrate-resistant acid phosphatase 5b). In vitro, bone marrow macrophages (BMMs) from MCP-1−/− and WT mice were cultured with M-CSF, RANKL and/or MCP-1. BMMs from MCP-1−/− mice showed decreased multinucleated osteoclast formation compared with WT mice. Taken together, our work demonstrates that MCP-1 has a role in PTH’s catabolic effects on bone including monocyte and macrophage recruitment, osteoclast formation, bone resorption, and cortical and trabecular bone loss.
The Habitats Humans Provide: Factors affecting the diversity and composition of arthropods in houses
Authors: Leong Misha , Bertone Matthew A. , Savage Amy M. , Bayless Keith M. , Dunn Robert R. , Trautwein Michelle D. 
Published: November 2017

AbstractThe indoor biome is a novel habitat which recent studies have shown exhibit not only high microbial diversity, but also high arthropod diversity. Here, we analyze findings from a survey of 50 houses (southeastern USA) within the context of additional survey data concerning house and room features, along with resident behavior, to explore how arthropod diversity and community composition are influenced by physical aspects of rooms and their usage, as well as the lifestyles of human residents. We found that indoor arthropod diversity is strongly influenced by access to the outdoors and carpeted rooms hosted more types of arthropods than non-carpeted rooms. Arthropod communities were similar across most room types, but basements exhibited more unique community compositions. Resident behavior such as house tidiness, pesticide usage, and pet ownership showed no significant influence on arthropod community composition. Arthropod communities across all rooms in houses exhibit trophic structure—with both generalized predators and scavengers included in the most frequently found groups. These findings suggest that indoor arthropods serve as a connection to the outdoors, and that there is still much yet to be discovered about their impact on indoor health and the unique ecological dynamics within our homes.
The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model
Authors: Hawkins Nicole A. , Lewis Michael , Hammond Rebecca S. , Doherty James J. , Kearney Jennifer A. 
Published: November 2017

AbstractDravet syndrome is an infant-onset epileptic encephalopathy with multiple seizure types that are often refractory to conventional therapies. Treatment with standard benzodiazepines like clobazam, in combination with valproate and stiripentol, provides only modest seizure control. While benzodiazepines are a first-line therapy for Dravet syndrome, they are limited by their ability to only modulate synaptic receptors. Unlike benzodiazepines, neuroactive steroids potentiate a wider-range of GABAA receptors. The synthetic neuroactive steroid SGE-516 is a potent positive allosteric modulator of both synaptic and extrasynaptic GABAA receptors. Prior work demonstrated anticonvulsant activity of SGE-516 in acute seizure assays in rodents. In this study, we evaluated activity of SGE-516 on epilepsy phenotypes in the Scn1a+/− mouse model that recapitulates many features of Dravet syndrome, including spontaneous seizures, premature death and seizures triggered by hyperthermia. To evaluate SGE-516 in Scn1a+/− mice, we determined the effect of treatment on hyperthermia-induced seizures, spontaneous seizure frequency and survival. SGE-516 treatment protected against hyperthermia-induced seizures, reduced spontaneous seizure frequency and prolonged survival in the Scn1a+/− mice. This provides the first evidence of SGE-516 activity in a mouse model of Dravet syndrome, and supports further investigation of neuroactive steroids as potential anticonvulsant compounds for refractory epilepsies.
A high-density consensus linkage map of white lupin highlights synteny with narrow-leafed lupin and provides markers tagging key agronomic traits
Authors: Książkiewicz Michał , Nazzicari Nelson , Yang Hua’an , Nelson Matthew N. , Renshaw Daniel , Rychel Sandra , Ferrari Barbara , Carelli Maria , Tomaszewska Magdalena , Stawiński Stanisław , Naganowska Barbara , Wolko Bogdan , Annicchiarico Paolo 
Published: November 2017

AbstractWhite lupin (Lupinus albus L.) is a valuable source of seed protein, carbohydrates and oil, but requires genetic improvement to attain its agronomic potential. This study aimed to (i) develop a new high-density consensus linkage map based on new, transcriptome-anchored markers; (ii) map four important agronomic traits, namely, vernalization requirement, seed alkaloid content, and resistance to anthracnose and Phomopsis stem blight; and, (iii) define regions of synteny between the L. albus and narrow-leafed lupin (L. angustifolius L.) genomes. Mapping of white lupin quantitative trait loci (QTLs) revealed polygenic control of vernalization responsiveness and anthracnose resistance, as well as a single locus regulating seed alkaloid content. We found high sequence collinearity between white and narrow-leafed lupin genomes. Interestingly, the white lupin QTLs did not correspond to previously mapped narrow-leafed lupin loci conferring vernalization independence, anthracnose resistance, low alkaloids and Phomopsis stem blight resistance, highlighting different genetic control of these traits. Our suite of allele-sequenced and PCR validated markers tagging these QTLs is immediately applicable for marker-assisted selection in white lupin breeding. The consensus map constitutes a platform for synteny-based gene cloning approaches and can support the forthcoming white lupin genome sequencing efforts.
The nature of ancient Egyptian copper-containing carbon inks is revealed by synchrotron radiation based X-ray microscopy
Authors: Christiansen Thomas , Cotte Marine , Loredo-Portales René , Lindelof Poul Erik , Mortensen Kell , Ryholt Kim , Larsen Sine 
Published: November 2017

AbstractFor the first time it is shown that carbon black inks on ancient Egyptian papyri from different time periods and geographical regions contain copper. The inks have been investigated using synchrotron-based micro X-ray fluorescence (XRF) and micro X-ray absorption near-edge structure spectroscopy (XANES) at the European Synchrotron Radiation Facility (ESRF). The composition of the copper-containing carbon inks showed no significant differences that could be related to time periods or the geographical locations. This renders it probable that the same technology for ink production was used throughout Egypt for a period spanning at least 300 years. It is argued that the black pigment material (soot) for these inks was obtained as by-products of technical metallurgy. The copper (Cu) can be correlated with the following three main components: cuprite (Cu2O), azurite (Cu3[CO3]2[OH]2) and malachite (Cu2CO3[OH]2).
Scalable symmetry detector and its applications by using beam splitters and weak nonlinearities
Authors: He Ying-Qiu , Ding Dong , Yan Feng-Li , Gao Ting 
Published: November 2017

AbstractWe describe a method to detect twin-beam multiphoton entanglement based on a beam splitter and weak nonlinearities. For the twin-beam four-photon entanglement, we explore a symmetry detector. It works not only for collecting two-pair entangled states directly from the spontaneous parametric down-conversion process, but also for generating them by cascading these symmetry detectors. Surprisingly, by calculating the iterative coefficient and the success probability we show that with a few iterations the desired two-pair can be obtained from a class of four-photon entangled states. We then generalize the symmetry detector to n-pair emissions and show that it is capable of determining the number of the pairs emitted indistinguishably from the spontaneous parametric down-conversion source, which may contribute to explore multipair entanglement with a large number of photons.
Sequencing and characterization of the complete mitochondrial genome of Japanese Swellshark (Cephalloscyllium umbratile)
Authors: Zhu Ke-Cheng , Liang Yin-Yin , Wu Na , Guo Hua-Yang , Zhang Nan , Jiang Shi-Gui , Zhang Dian-Chang 
Published: November 2017

AbstractTo further comprehend the genome features ofCephalloscyllium umbratile(Carcharhiniformes), an endangered species, the complete mitochondrial DNA (mtDNA) was firstly sequenced and annotated. The full-length mtDNA ofC. umbratilewas 16,697 bp and contained ribosomal RNA (rRNA) genes, 13 protein-coding genes (PCGs), 23 transfer RNA (tRNA) genes, and a major non-coding control region. Each PCG was initiated by an authoritative ATN codon, except forCOX1initiated by a GTG codon. Seven of 13 PCGs had a typical TAA termination codon, while others terminated with a single T or TA. Moreover, the relative synonymous codon usage of the 13 PCGs was consistent with that of other published Carcharhiniformes. All tRNA genes had typical clover-leaf secondary structures, except for tRNA-Ser (GCT), which lacked the dihydrouridine ‘DHU’ arm. Furthermore, the analysis of the average Ka/Ks in the 13 PCGs of three Carcharhiniformes species indicated a strong purifying selection within this group. In addition, phylogenetic analysis revealed thatC. umbratilewas closely related toGlyphis glyphisandGlyphis garricki. Our data supply a useful resource for further studies on genetic diversity and population structure ofC. umbratile.
Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma
Authors: Peng Zhenzi , Wang Jun , Shan Bin , Yuan Fulai , Li Bin , Dong Yeping , Peng Wei , Shi Wenwen , Cheng Yuanda , Gao Yang , Zhang Chunfang , Duan Chaojun 
Published: November 2017

AbstractLncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lncRNAs in a cohort of 42 tumor tissues and adjacent normal tissues. R and Bioconductor were used for data analysis. A total of 3045 lncRNAs were differentially expressed between the paired tumor and normal tissues (1048 up and 1997 down). Meanwhile, our data showed that the expression NONHSAT077036 was associated with N classification and clinical stage. Further, we analyzed the potential co-regulatory relationship between the lncRNAs and their potential target genes using the ‘cis’ and ‘trans’ models. In the 25 related transcription factors (TFs), our analysis of The Cancer Genome Atlas database (TCGA) found that patients with lower expression of POU2F2 and higher expression of TRIM28 had a shorter overall survival time. The POU2F2 and TRIM28 co-expressed lncRNA landscape characterized here may shed light into normal biology and lung adenocarcinoma pathogenesis, and be valuable for discovery of biomarkers.
Rapid and selective surface functionalization of the membrane for high efficiency oil-water separation via an atmospheric pressure plasma process
Authors: You Yong Sung , Kang Seongchan , Mauchauffé Rodolphe , Moon Se Youn 
Published: November 2017

AbstractOil-water separation is a worldwide challenge because of the increasing production of industrial oily wastewater and frequent oil spills. The growing environmental and economic demands emphasize the need to develop effective solutions to separate oil and water. Recently, oil-water separation methods were developed by tuning the wettability of membranes via surface functionalization. However, the industrialization of such methods remains challenging due to the easy-fouling, high cost and complex fabrication. Herein, a simple and rapid pathway to separate oil from oil-water mixtures is reported using plasma surface functionalization in an open-air environment. The fine tuning and study of the plasma process parameters enables the selective functionalization of each side of the membranes which led respectively to a superhydrophobic-superoleophilic and superhydrophobic-oleophobic sides. The successful separation, without any external force, of a 50 mL oil-water solution in 6 minutes was achieved. This work paves the way for an efficient, low cost and easily upscalable method for oil-water separation due to the high versatility of the atmospheric pressure plasma processes.
Identification of a Novel Nonsense Variant in the SCN1A Gene that Causes Febrile Seizure Disorder
Authors: MarchoudI Nabila , Rouissi Abdelfettah , Fekkak Jamal , Jouali Farah 
Published: November 2017

AbstractThe SCN1A gene, encoding for the voltage-gated sodium channel Nav1.1, is the most clinically relevant epilepsy gene, with most mutations having been documented in a spectrum of epilepsy syndromes, ranging from the relatively benign generalized epilepsy with febrile seizures plus (GEFS+) to severe myoclonic epilepsy in infancy (SMEI), and other rare febrile seizure disorders. To date, more than 1,250 mutations in SCN1A have been linked to epilepsy. In this case, we describe a novel nonsense pathogenic variant (NM_001202435.1; c.327C > G) in SCN1A in a 10-month Moroccan infant with febrile seizure disorder.
Postarthroscopy Osteonecrosis of the Knee: Current Concepts
Authors: Di Caprio Francesco , Meringolo Renato , Navarra Maria , Mosca Massimiliano , Ponziani Lorenzo 
Published: November 2017

AbstractKnee osteonecrosis is a severe disease rapidly leading to end-stage osteoarthritis, which was classified into three categories: spontaneous, secondary, and postarthroscopy. To understand postarthroscopy osteonecrosis of the knee, all the three types of knee osteonecrosis have to be deepened. This article reviewed spontaneous and secondary osteonecroses of the knee, with special focus upon postarthroscopy osteonecrosis, which is a rare form, affecting patients operated for arthroscopic knee surgery, most commonly for meniscectomy. Due to its rarity, patients and surgeons are often unprepared for this complication. A correct diagnosis is essential for appropriate treatment, and also to determine if a preexisting osteonecrosis was present, avoiding medicolegal sequelae, although many authors agree that osteonecrosis (both spontaneous and postarthroscopy) represent unpreventable and unpredictable conditions. In spontaneous osteonecrosis, the treatment is defined according to the size and the degree of the lesion, whereas in postarthroscopy osteonecrosis, the size of the lesion has no prognostic value, and therefore, the choice of the correct treatment is based more on the timing of the diagnosis. A diagnostic and therapeutic algorithm was outlined on the basis of the actual knowledge.
Characterization of Focal Liver Lesions using CEUS and MRI with Liver-Specific Contrast Media: Experience of a Single Radiologic Center
Authors: Beyer Lukas , Wassermann Florian , Pregler Benedikt , Michalik Katharina , Rennert Janine , Wiesinger Isabel , Stroszczynski Christian , Wiggermann Philipp , Jung Ernst 
Published: November 2017

Abstract
Aim The purpose of this study was to compare contrast-enhanced ultrasound (CEUS), magnetic resonance imaging (MRI) using liver-specific contrast agent and a combination of both for the characterization of focal liver lesions (FLL).
Methods 83 patients with both benign and malignant liver lesions were examined using CEUS and MRI after the intravenous administration of liver-specific contrast media. All patients had inconclusive results from prior imaging examinations. Histopathological specimens could be obtained in 53 patients. Ultrasound was performed using a multi-frequency curved probe (1 – 6 MHz) after the injection of 1 – 2.4 ml ultrasound contrast media. The sensitivity, specificity, positive predictive value and negative predictive value of CEUS, MRI and a combination of both (CEUS + MRI) were compared.
Results The sensitivity, specificity, positive and negative predictive values regarding lesion classification were 90.9 %, 70.6 %, 92.3 % and 66.6 %, respectively, for CEUS; 90.9 %, 82.4 %, 95.2 % and 70.0 %, respectively, for MRI; and 96.9 %, 70.6 %, 92.7 % and 85.7 % respectively, for CEUS + MRI. There were no statistically significant differences. 6 malignant lesions were missed using CEUS or MRI alone (false negatives). The use of both modalities combined reduced the false-negative results to 2.
Conclusion CEUS and MRI with liver-specific contrast media are very reliable and of equal informative value in the characterization of focal liver lesions. The number of false-negative results can be decreased using a combination of the two methods.
Ambulante Nachsorge von chronischen Schlaganfallpatienten mit Physiotherapie, Ergotherapie und Logopädie
Authors: Zein Katrin , Saal Susanne 
Published: November 2017

Zusammenfassung
Fragestellung Das Krankheitsbild des Schlaganfalls führt zu hohen Aktivitäts- und Partizipationsverlusten der Betroffenen. Die vorliegende Untersuchung fragt nach dem Gesundheitszustand von Patienten mit Schlaganfall im chronischen Stadium, der Versorgungshäufigkeit mit ambulanten Therapien und den Einflussfaktoren auf die Inanspruchnahme von Heilmittelleistungen.
Material und Methoden Sekundärdatenanalyse einer standardisierten Befragung von 111 Patienten zur Funktionsfähigkeit nach Schlaganfall und zur Heilmittelversorgung.
Ergebnisse Ein Jahr nach stationärer Entlassung leiden ein Viertel der befragten Schlaganfallpatienten an schweren bis sehr schweren Funktionseinschränkungen insbesondere in den Bereichen Kraft, Handkraft, Mobilität und Aktivitäten des täglichen Lebens. 54,2% aller Befragten erhalten Heilmittel, wobei 45,4% aller Patienten Physiotherapie, 16,8% Ergotherapie und 18,1% Logopädie erhalten. Eine multiple Regressionsanalyse identifizierte insbesondere Kommunikations- und körperliche Funktionsfähigkeit als signifikante Einflussfaktoren auf die Inanspruchnahme von ambulanten Therapien.
Diskussion und Schlussfolgerung Mind. jeder dritte Patient mit Einschränkungen ist ein Jahr nach Schlaganfall ohne entsprechende Heilmittelversorgung. Die Versorgung mit Heilmitteln kann in dieser Subpopulation als nicht ausreichend betrachtet werden. In der Langzeitversorgung von Schlaganfallpatienten sollte die Versorgung von Patienten mit Sprech- Sprach-, und Schluckstörungen sowie die Versorgung von Älteren mehr Beachtung finden.
Chronische zervikale Schmerzsyndrome. Vorstellung eines multimodalen interdisziplinären stationären Behandlungskonzepts (ANOA-Konzept)
Authors: Niemier Kay , Hogrefe Hans-Christian 
Published: November 2017

ZusammenfassungChronische zervikale Schmerzsyndrome beruhen in der Regel auf einer komplexen Befundlage. Funktionelle, psychosoziale und morphologische Befunde führen in unterschiedlichster Kombination zu chronischen Schmerzerkrankungen. Um eine gezielte Therapiestrategie zu entwickeln, bedarf es einer multimodalen interdisziplinären Diagnostik. In dieser können die unterschiedlichsten Einflussfaktoren herausgearbeitet, gewertet und in ein gezieltes Therapieprogramm umgesetzt werden. Das ANOA-Konzept verbindet die multimodale Schmerztherapie mit der Differenzialdiagnostik und -Therapie der pathogenetisch wichtigen Funktionsstörungen des Bewegungssystems. Diese werden nicht nur als Auslöser oder Sekundärphänomen chronischer Schmerzen verstanden, sondern als eigenständiger Einflussfaktor.
Sind wir noch zu retten?
Authors: Rammler Nina , Spier Birte 
Published: November 2017

Zusammenfassung
Probleme des frühzeitigen Ausstiegs aus dem Pflegeberuf Ist der
frühzeitige Ausstieg aus dem Pflegeberuf eine Bedrohung für den Berufsstand? Was
kann getan werden, um den Pflegeberuf und somit auch die pflegerische Versorgung
von Patienten und Pflegebedürftigen zukünftig sicherzustellen? Was müssen
Arbeitgeber tun, um qualifizierte Pflegekräfte an sich zu binden? Diesen Fragen
ist die Autorin in einer Literaturarbeit im Rahmen ihrer Fachweiterbildung für
Anästhesie- und Intensivpflege nachgegangen und hat damit beim Thieme
Intensiv-Pflegepreis 2016 den 1. Platz belegt. Die Kernfrage Ihres Beitrags
lautet: Wer pflegt uns 2050?
Notfallpflege – was ist das eigentlich?
Authors: Dormann Patrick , Wedler Katrin , Machner Mareen , Fuchs Andreas 
Published: November 2017

Zusammenfassung
Begriffserklärung Ein medizinischer Notfall ist ein hochkomplexer Begriff, der nicht so einfach erklärt werden kann. Ähnlich schwierig
ist es, Notfallpflege zu beschreiben. Eine Expertengruppe aus Pflegekräften mit umfangreichen Erfahrungen im Notaufnahme-Setting hat sich
zum Ziel gesetzt, eine Begriffserklärung zu finden. Wir stellen die Ergebnisse vor.
Praxisentwicklung durch APN in der Kinderintensivpflege
Authors: Hock Simone , Lang Janina , Meissner Kerstin , Schmitt Anne , Werner Janne 
Published: November 2017

Zusammenfassung
ANP in der Pflegepraxis Pflegeexpertinnen APN – Advanced Practice Nurses – verfügen über einen pflegerischen Master-Abschluss und
haben sich Expertenwissen angeeignet. Sie verstehen sich als Bindeglied zwischen betroffenen Familien und an der Gesundheitsversorgung
beteiligten Mitarbeitern ebenso wie zwischen den involvierten Berufsdisziplinen untereinander. Dabei spezialisieren sie sich meist auf eine
bestimmte Zielgruppe und erweitern das traditionelle pflegerische Aufgabenspektrum. Der folgende Beitrag schildert, wie die spezialisierte
und erweiterte Pflegepraxis der APNs in der Kinderintensivpflege auch langsam in Deutschland ankommt und stellt den speziellen
Aufgabenbereich dieser Pflegeexpertinnen APN vor.