bluuebunny/crossref_metadata_2025_split huggingface dataset:
An interspecies comparative study of invasive electrophysiological functional connectivity
Authors: Casimo Kaitlyn , Levinson Lila H. , Zanos Stavros , Gkogkidis C. Alexis , Ball Tonio , Fetz Eberhard , Weaver Kurt E. , Ojemann Jeffrey G. 
Published: November 2017

AbstractIntroductionResting‐state connectivity patterns have been observed in humans and other mammal species, and can be recorded using a variety of different technologies. Functional connectivity has been previously compared between species using resting‐state fMRI, but not in electrophysiological studies.MethodsWe compared connectivity with implanted electrodes in humans (electrocorticography) to macaques and sheep (microelectrocorticography), which are capable of recording neural data at high frequencies with spatial precision. We specifically examined synchrony, implicated in functional integration between regions.ResultsWe found that connectivity strength was overwhelmingly similar in humans and monkeys for pairs of two different brain regions (prefrontal, motor, premotor, parietal), but differed more often within single brain regions. The two connectivity measures, correlation and phase locking value, were similar in most comparisons. Connectivity strength agreed more often between the species at higher frequencies. Where the species differed, monkey synchrony was stronger than human in all but one case. In contrast, human and sheep connectivity within somatosensory cortex diverged in almost all frequencies, with human connectivity stronger than sheep.DiscussionOur findings imply greater heterogeneity within regions in humans than in monkeys, but comparable functional interactions between regions in the two species. This suggests that monkeys may be effectively used to probe resting‐state connectivity in humans, and that such findings can then be validated in humans. Although the discrepancy between humans and sheep is larger, we suggest that findings from sheep in highly invasive studies may be used to provide guidance for studies in other species.
Functional plurihormonal adrenal oncocytoma: case report and literature review
Authors: Costanzo Pablo René , Paissan Andrea Laura , Knoblovits Pablo 
Published: November 2017

Key Clinical MessageWe present a 27‐year‐old woman with an adrenal oncocytoma. This is a very rare entity. We provide a review of the clinical, biochemical and pathological features of cases reported in the literature.
Molecular Engineering of MnII Diamine Diketonate Precursors for the Vapor Deposition of Manganese Oxide Nanostructures
Authors: Maccato Chiara , Bigiani Lorenzo , Carraro Giorgio , Gasparotto Alberto , Seraglia Roberta , Kim Jiyeon , Devi Anjana , Tabacchi Gloria , Fois Ettore , Pace Giuseppe , Di Noto Vito , Barreca Davide 
Published: November 2017

AbstractMolecular engineering of manganese(II) diamine diketonate precursors is a key issue for their use in the vapor deposition of manganese oxide materials. Herein, two closely related β‐diketonate diamine MnII adducts with different fluorine contents in the diketonate ligands are examined. The target compounds were synthesized by a simple procedure and, for the first time, thoroughly characterized by a joint experimental–theoretical approach, to understand the influence of the ligand on their structures, electronic properties, thermal behavior, and reactivity. The target compounds are monomeric and exhibit a pseudo‐octahedral coordination of the MnII centers, with differences in their structure and fragmentation processes related to the ligand nature. Both complexes can be readily vaporized without premature side decompositions, a favorable feature for their use as precursors for chemical vapor deposition (CVD) or atomic layer deposition applications. Preliminary CVD experiments at moderate growth temperatures enabled the fabrication of high‐purity, single‐phase Mn3O4 nanosystems with tailored morphology, which hold great promise for various technological applications.
Pillar[5]arene‐Based Supramolecular Organic Framework with Multi‐Guest Detection and Recyclable Separation Properties
Authors: Lin Qi , Fan Yan‐Qing , Mao Peng‐Peng , Liu Lu , Liu Juan , Zhang You‐Ming , Yao Hong , Wei Tai‐Bao 
Published: November 2017

AbstractThe selective detection and separation of target ions or molecules is an intriguing issue. Herein, a novel supramolecular organic framework (SOF‐THBP) was constructed by bis‐thioacetylhydrazine functionalized pillar[5]arenes. The SOF‐THBP shows a fluorescent response for Fe3+, Cr3+, Hg2+ and Cu2+ ions. The xerogel of SOF‐THBP shows excellent recyclable separation properties for these metal ions and the absorption rates were up to 99.29 %. More interestingly, by rationally introducing these metal ions into the SOF‐THBP, a series of metal‐ion‐coordinated SOFs (MSOFs) such as MSOF‐Fe, MSOF‐Hg and MSOF‐Cu were constructed. These metal ions coordinated MSOFs could selectively sense F−, Br−, and l‐Cys, respectively. The detection limits of these MSOFs for F−, Br− and l‐Cys were about 10−8 m.
Depolymerization of Poly(phosphinoboranes): From Polymers to Lewis Base Stabilized Monomers
Authors: Marquardt Christian , Hegen Oliver , Vogel Ariane , Stauber Andreas , Bodensteiner Michael , Timoshkin Alexey Y. , Scheer Manfred 
Published: November 2017

AbstractWe report on depolymerization reactions of poly(phosphinoboranes). The cleavage of the polymers [H2PBH2]n (2 a), [tBuHPBH2]n (2 c), [PhHPBH2]n (2 e) and the oligomer [Ph2PBH2]n (2 b), with strong Lewis bases (LBs), in particular with NHCs, leads to the corresponding monomeric phosphanylboranes R1R2PBH2LB. It is observed that the depolymerization depends on the strength and stability of the LBs as well as on the substitution pattern of the poly(phosphinoboranes). The solid state structures of the monomeric phosphinoboranes H2PBH2NHCMe (NHC=N‐heterocyclic carbene) (4 a), H2PBH2NHCdipp (5 a) and tBuHPBH2NHCMe (4 c) were determined. DFT calculations support the experimentally observed reaction behavior.
Influence of the Anion on the Oxidation of 5‐Hydroxymethylfurfural by Using Ionic‐Polymer‐Supported Platinum Nanoparticle Catalysts
Authors: Siankevich Sviatlana , Mozzettini Simone , Bobbink Felix , Ding Shipeng , Fei Zhaofu , Yan Ning , Dyson Paul J. 
Published: November 2017

AbstractInvited for this month's cover are the groups of Prof. Paul J. Dyson at Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland and Prof. Ning Yan at National University of Singapore, Singapore. The cover shows the catalytic conversion of 5‐hydroxymethylfurfural (5‐HMF) into 2,5‐furandicarboxylic acid catalyzed by platinum nanoparticles stabilized by polymeric imidazolium salts. The catalyst is represented by a nanoparticle footprint. The background represents a potential source of biomass. Read the full text of the article at 10.1002/cplu.201700344.
Regional patterns of increasing Swiss needle cast impacts on Douglas‐fir growth with warming temperatures
Authors: Lee E. Henry , Beedlow Peter A. , Waschmann Ronald S. , Tingey David T. , Cline Steven , Bollman Michael , Wickham Charlotte , Carlile Cailie 
Published: November 2017

AbstractThe fungal pathogen,Phaeocryptopus gaeumannii, causing Swiss needle cast (SNC) occurs wherever Douglas‐fir is found but disease damage is believed to be limited in the U.S. Pacific Northwest (PNW) to the Coast Range of Oregon and Washington (Hansen et al.,Plant Disease, 2000,84, 773; Rosso & Hansen,Phytopathology, 2003,93, 790; Shaw, et al.,Journal of Forestry, 2011,109, 109). However, knowledge remains limited on the history and spatial distribution ofSNCimpacts in thePNW. We reconstructed the history ofSNCimpacts on mature Douglas‐fir trees based on tree‐ring width chronologies from western Oregon. Our findings show thatSNCimpacts on growth occur wherever Douglas‐fir is found and is not limited to the coastal fog zone. The spatiotemporal patterns of growth impact fromSNCdisease were synchronous across the region, displayed periodicities of 12–40 years, and strongly correlated with winter and summer temperatures and summer precipitation. The primary climatic factor limiting pathogen dynamics varied spatially by location, topography, and elevation.SNCimpacts were least severe in the first half of the 20th century when climatic conditions during the warm phase of the Pacific Decadal Oscillation (1924–1945) were less conducive to pathogen development. At low‐ to mid‐elevations,SNCimpacts were most severe in 1984–1986 following several decades of warmer winters and cooler, wetter summers including a high summer precipitation anomaly in 1983. At high elevations on the west slope of the Cascade Range,SNCimpacts peaked several years later and were the greatest in the 1990s, a period of warmer winter temperatures. Climate change is predicted to result in warmer winters and will likely continue to increaseSNCseverity at higher elevations, north along the coast from northern Oregon to British Columbia, and inland where low winter temperatures currently limit growth of the pathogen. Our findings indicate thatSNCmay become a significant forest health problem in areas of thePNWbeyond the coastal fog zone.
Early warning signals precede cyanobacterial blooms in multiple whole‐lake experiments
Authors: Wilkinson Grace M. , Carpenter Stephen R. , Cole Jonathan J. , Pace Michael L. , Batt Ryan D. , Buelo Cal D. , Kurtzweil Jason T. 
Published: November 2017

AbstractEcosystem regime shifts are abrupt changes from one dynamical state to another, such as the shift from a clear‐water state to an algal bloom state in lakes. These transitions are hard to forecast but theory suggests that early warning indicators can predict impending regime shifts that may allow for management intervention to prevent or mitigate an unwanted change. The efficacy of early warning indicators has been demonstrated in modeling and laboratory experiments, but rarely in the field, where environmental drivers are numerous and interacting. It is unclear if early warning indicators are observable or timely enough to allow for intervention under these conditions. We performed six whole‐lake experimental nutrient additions to test the utility of early warning indicators for predicting the regime shift from a clear‐water state to a cyanobacteria‐dominated state. The lakes were monitored for increases in resilience indicators including rises in standard deviation and autocorrelation of algal pigments and dissolved oxygen saturation. A statistical method, quickest detection, determined when resilience indicators in manipulated lakes deviated substantially from those in a reference ecosystem. Blooms occurred in five of the six lake‐years. Although there was substantial variability in bloom size and timing, at least one indicator foreshadowed the peak chlorophyll a concentration in all instances. Early warnings occurred 1–57 d prior to a bloom, which in some instances, may allow managers to notify the public or intervene to prevent blooms. The resilience indicators generally identified changes in resilience over time within a lake and also ranked large differences in resilience among lakes. Our findings suggest that resilience indicators can be useful for classifying ecosystems on a landscape and across time with respect to proximity to a critical threshold.
Co2SnO4/Carbon Nanotubes Composites: A Novel Approach for Electrochemical Sensing of Hydrogen Peroxide
Authors: Yedinak E. , Venegas C. J. , Brito T. P. , Ruiz‐León D. , Bollo S. 
Published: November 2017

AbstractFor the first time Co2SnO4 (CTO)/Carbon nanotubes (CNT) composites were prepared and used to modify glassy carbon electrodes for the amperometric determination of hydrogen peroxide. The catalytic activity of composites towards the oxidation of hydrogen peroxide was dependent on the quantity of CNT present in the composite and to the pH of the medium. The pure cobalt stannate phase with a ratio of 3 : 1 (CTO:CNT) exhibited the best catalytic activity towards hydrogen peroxide oxidation at low potentials (0.200 and 0.500 V). A linear relationship between current and hydrogen peroxide concentration was obtained with a sensitivity of 95 and 258 μA mM−1 and a detection limit of 0.130 and 0.08 μM respectively.
Toxicological characterization of ZnO nanoparticles in malignant and non‐malignant cells
Authors: Moratin Helena , Scherzad Agmal , Gehrke Thomas , Ickrath Pascal , Radeloff Katrin , Kleinsasser Norbert , Hackenberg Stephan 
Published: November 2017

The increasing usage of zinc oxide nanoparticles (ZnO‐NPs) in industrial applications as well as in consumer products raises concern regarding their potential adverse effects to a greater extend. Numerous studies have demonstrated toxic properties of NPs, however there is still a lack of knowledge concerning the underlying mechanisms. This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO‐NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non‐malignant cells. Therefore, human head and neck squamous cell carcinoma‐derived FaDu cells were incubated with 4–20 µg/ml of ZnO‐NPs for 1–48 hr and tested for cell viability, cell cycle alterations, apoptosis and caspase‐3 gene expression as a sensitive marker of molecular apoptotic processes with regard to time‐ and dose‐dependent effects. Human mesenchymal bone marrow stem cells were used as non‐malignant representatives to examine oxidative stress‐related genotoxicity. Results showed a significant reduction in cell viability as well as dose‐ and time‐dependent increase of apoptotic cells following nanoparticle treatment. Likewise, caspase‐3 gene expression enhanced already before first apoptotic cells were detectable. It could be observed that doses that were cytotoxic in tumor cells did not reduce viability in stem cells. However, the same concentrations already induced significant DNA damage. The findings of the study suggest to keep a more critical eye on the use of nanoparticles as anti‐cancer agents. Yet, additional in vivo studies are needed to assess safety concerns for consumers and patients. Environ. Mol. Mutagen. 59:247–259, 2018. © 2017 Wiley Periodicals, Inc.
An efficient algorithm for identifying pulse‐like ground motions based on significant velocity half‐cycles
Authors: Zhai Changhai , Li Cuihua , Kunnath Sashi , Wen Weiping 
Published: November 2017

SummaryGround motions with strong velocity pulses are of particular interest to structural earthquake engineers because they have the potential to impose extreme seismic demands on structures. Accurate classification of records is essential in several earthquake engineering fields where pulse‐like ground motions should be distinguished from nonpulse‐like records, such as probabilistic seismic hazard analysis and seismic risk assessment of structures. This study proposes an effective method to identify pulse‐like ground motions having single, multiple, or irregular pulses. To effectively characterize the intrinsic pulse‐like features, the concept of an energy‐based significant velocity half‐cycle, which is visually identifiable, is first presented. Ground motions are classified into 6 categories according to the number of significant half‐cycles in the velocity time series. The pulse energy ratio is used as an indicator for quantitative identification, and then the energy threshold values for each type of ground motions are determined. Comprehensive comparisons of the proposed approach with 4 benchmark identification methods are conducted, and the results indicate that the methodology presented in this study can more accurately and efficiently distinguish pulse‐like and nonpulse‐like ground motions. Also presented are some insights into the reasons why many pulse‐like ground motions are not detected successfully by each of the benchmark methods.
Anterior thalamic nuclei lesions have a greater impact than mammillothalamic tract lesions on the extended hippocampal system
Authors: Perry Brook A. L. , Mercer Stephanie A. , Barnett Sophie C. , Lee Jungah , Dalrymple‐Alford John C. 
Published: November 2017

AbstractThe anterior thalamic nuclei (ATN), mammillary bodies and their interconnecting fiber tract, the mammillothalamic tract (MTT), are important components of an extended hippocampal circuit for episodic memory. In humans, damage to the MTT or ATN in many disorders is associated with severe anterograde amnesia and it is assumed that their influence on memory is functionally equivalent. The relative influence of these two structures on memory has not, however, been assessed explicitly. Here, a direct comparison found that only ATN lesions impaired spatial reference memory in rats. ATN lesions produced more severe deficits on spatial working memory and reduced zif268 expression to a greater degree and in more corticolimbic sites than did MTT lesions. Conversely, MTT lesions reduced NeuN cell counts in all three subregions of the MB to a greater extent than did ATN lesions, so their relative impact cannot be explained by retrograde neuropathology of the MB. Hence ATN injury causes a more critical dysfunction than would be expected by an emphasis on the indirect influence of brainstem inputs to the extended memory system. The greater ATN lesion deficits found here may represent the consequence of disruption to the direct connections of the ATN with both hippocampal and cortical sites.
Stereospecific control of peptide gas‐phase ion chemistry with cis and trans cyclo ornithine residues
Authors: Marek Aleš , Nguyen Huong T.H. , Brož Břetislav , Tureček František 
Published: November 2017

AbstractWe report non‐chiral amino acid residues cis‐ and trans‐1,4‐diaminocyclohexane‐1‐carboxylic acid (cyclo‐ornithine, cO) that exhibit unprecedented stereospecific control of backbone dissociations of singly charged peptide cations and hydrogen‐rich cation radicals produced by electron‐transfer dissociation. Upon collision‐induced dissociation (CID) in the slow heating regime, peptide cations containing trans‐cO residues undergo facile backbone cleavages of amide bonds C‐terminal to trans‐cO. By contrast, peptides with cis‐cO residues undergo dissociations at several amide bonds along the peptide ion backbone. Diastereoisomeric cO‐containing peptides thus provide remarkably distinct tandem mass spectra. The stereospecific effect in CID of the trans‐cO residue is explained by syn‐facially directed proton transfer from the 4‐ammonium group at cO to the C‐terminal amide followed by neighboring group participation in the cleavage of the CO―NH bond, analogous to the aspartic acid and ornithine effects. Backbone dissociations of diastereoisomeric cO‐containing peptide ions generate distinct [bn]+‐type fragment ions that were characterized by CID‐MS3 spectra. Stereospecific control is also reported for electron‐transfer dissociation of cis‐ and trans‐cO containing doubly charged peptide ions. The stereospecific effect upon electron transfer is related to the different conformations of doubly charged peptide ions that affect the electron attachment sites and ensuing N―Cα bond dissociations.
A principal component analysis based model to predict post‐monsoon tropical cyclone activity in the Bay of Bengal using oceanic Niño index and dipole mode index
Authors: Biswas H. R. , Kundu P. K. 
Published: November 2017

ABSTRACTEl Niño Southern Oscillation (ENSO) and Indian Ocean dipole (IOD) play an important role in determining the weather pattern over the Indian subcontinent region. The role of ENSO and IOD on the occurrence of tropical cyclone activity during post‐monsoon season (October–December) over the Bay of Bengal (BoB) has been investigated through an objective analysis of observed data for the period of 1990–2015. Accumulated cyclone energy (ACE) index is an important measure of tropical cyclone activity over a basin for a defined period of time. Sea‐surface temperature (SST) anomalies in the Niño 3.4 region (oceanic Niño index) is negatively correlated at 95% confidence level of significance with ACE over the BoB during post‐monsoon season. Positive phase of IOD has negative impact on the tropical cyclone formation over the BoB. The ACE has large inter‐annual variability with coefficient of variation 124% for tropical cyclone activity over BoB during post‐monsoon season. Frequency distribution of annual ACE values for post‐monsoon season over the BoB indicated that cold phases of ENSO along with negative IOD index values are the most favourable for development of tropical cyclone over the BoB. Principal component regression (PCR) model developed by cross‐verification method based on training period data for 1990–2013 and ONI and DMI values of different lag periods as predictors is found to be functional for both deterministic and probabilistic prediction of ACE values of post‐monsoon season. Above‐ and below‐normal TC activities were observed in 2014 and 2015, respectively, which have been well predicted by the PCR model.
Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential
Authors: Pak Linda M. , Kemeny Nancy E. , Capanu Marinela , Chou Joanne F. , Boucher Taryn , Cercek Andrea , Balachandran Vinod P. , Kingham T. Peter , Allen Peter J. , DeMatteo Ronald P. , Jarnagin William R. , D'Angelica Michael I. 
Published: November 2017

Background/ObjectivesCombination hepatic artery infusion (HAI) and systemic (SYS) chemotherapy for unresectable CRLM results in high tumor‐response rates. This study represents an update of long‐term survival and conversion to resectability in patients with unresectable CRLM treated with HAI and SYS chemotherapy in a phase II study.MethodThe primary endpoint was complete resection. Multivariate and landmark analysis assessed the effect of complete resection on progression‐free (PFS) and overall survival (OS).ResultsFrom 2007 to 2012, 64 patients with median of 13 tumors were enrolled; 67% had prior chemotherapy. 33 patients (52%) were converted to resection. Median follow‐up among survivors was 81 months. Median PFS and OS were 13 and 38 months, respectively, with 5‐year‐OS of 36%. Chemotherapy‐naïve patients had 5‐year‐OS of 51%. Conversion to resection was the only independent factor prognostic of improved PFS and OS. Nine of 64 patients (14%) are NED (five since initial resection, three after resection of recurrent disease, one from chemotherapy alone) at median follow‐up of 86 months from treatment initiation, and 72 months from last operative intervention.ConclusionCombination HAI and SYS is an effective therapy for high‐volume unresectable CRLM, resulting in a high rate of resection, long‐term survival, and the potential for cure.