bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic health record and genome-wide genetic data in Generation Scotland participants
Authors: Kerr Shona M. , Campbell Archie , Marten Jonathan , Vitart Veronique , McIntosh Andrew M , Porteous David J. , Hayward Caroline 
Published: September 2017

This article provides the first detailed demonstration of the research value of the Electronic Health Record (EHR) linked to research data in Generation Scotland Scottish Family Health Study (GS:SFHS) participants, together with how to access this data. The structured, coded variables in the routine biochemistry, prescribing and morbidity records, in particular, represent highly valuable phenotypic data for a genomics research resource. Access to a wealth of other specialized datasets, including cancer, mental health and maternity inpatient information, is also possible through the same straightforward and transparent application process. The EHR linked dataset is a key component of GS:SFHS, a biobank conceived in 1999 for the purpose of studying the genetics of health areas of current and projected public health importance. Over 24,000 adults were recruited from 2006 to 2011, with broad and enduring written informed consent for biomedical research. Consent was obtained from 23,603 participants for GS:SFHS study data to be linked to their Scottish National Health Service (NHS) records, using their Community Health Index number. This identifying number is used for NHS Scotland procedures (registrations, attendances, samples, prescribing and investigations) and allows healthcare records for individuals to be linked across time and location. Here, we describe the NHS EHR dataset on the sub-cohort of 20,032 GS:SFHS participants with consent and mechanism for record linkage plus extensive genetic data. Together with existing study phenotypes, including family history and environmental exposures, such as smoking, the EHR is a rich resource of real world data that can be used in research to characterise the health trajectory of participants, available at low cost and a high degree of timeliness, matched to DNA, urine and serum samples and genome-wide genetic information.
Measuring Agency Costs over the Business Cycle
Authors: Westermann Ramona 
Published: September 2017

This paper investigates the joint effects of manager–shareholder agency conflicts and macroeconomic risk on corporate policies and firm value. I first derive the implications of a structural model of a firm with assets in place and an investment opportunity, run by a self-interested manager who captures part of the firm’s net income as private benefits. The model implies that dynamic aggregate agency costs are driven by firms in the upper half of the distribution of private benefits. Managers of those firms capture 0.8% of firms’ net income on average, thereby decreasing aggregate firm value by 1.7%. These agency costs are procyclical (1.9% in booms and 1.4% in recessions) because managerial underleverage decreases default costs particularly in recessions. Furthermore, the model can explain empirical regularities, including the joint level and cyclicality of leverage.The Internet appendix is available at https://doi.org/10.1287/mnsc.2017.2813 .This paper was accepted by Gustavo Manso, finance.
Opposite Elements in Clutters
Authors: Abdi Ahmad , Fukasawa Ricardo , Sanità Laura 
Published: September 2017

Let E be a finite set of elements, and let L be a clutter over ground set E. We say distinct elements e, f are opposite if every member and every minimal cover of L contains at most one of e, f. In this paper, we investigate opposite elements and reveal a rich theory underlying such a seemingly simple restriction. The clutter C obtained from L after identifying some opposite elements is called an identification of L; inversely, L is called a split of C. We will show that splitting preserves three clutter properties, i.e., idealness, the max-flow min-cut property, and the packing property. We will also display several natural examples in which a clutter does not have these properties but a split of them does. We will develop tools for recognizing when splitting is not a useful operation, and as well, we will characterize when identification preserves the three mentioned properties. We will also make connections to spanning arborescences, Steiner trees, comparability graphs, degenerate projective planes, binary clutters, matroids, as well as the results of Menger, Ford and Fulkerson, the Replication Conjecture, and a conjecture on ideal, minimally nonpacking clutters.
Numerical and experimental studies of compression-tested copper, mortar contact method
Authors: Torrente Prato Gabriel Jesús 
Published: September 2017

La simulación del ensayo de compresión del cobre se realizó con el método de contacto con mortero y asume: simetría axial, restricción de puntos múltiples de tipo plano, carga concentrada y fricción coulombiana. El cobre se simula como material isotrópico, elástico hasta fluencia, y luego como un material endurecible con plasticidad incremental. El comportamiento del cobre se calculó a partir de experimentos. Se realizaron diecisiete ensayos de compresión sin lubricación a muestras cilíndricas a temperatura ambiente. La relación Esfuerzo vs. Deformación se calculó usando dos correcciones por fricción; La Corrección de Rowe y la Corrección Dieter. Se concluye que: la simulación realizada con el método de contacto con mortero y la Corrección Dieter es una buena alternativa para simular la prueba de compresión, siendo la diferencia entre la simulación y los experimentales inferior a 7,33%, la hipótesis de simetría axial no aleja la simulación de la realidad y nuevos análisis numérico permitirán el desarrollo de mejores correcciones por fricción.
First human heart transplantation in the national and foreign history of medicine
Authors: Ivanyushkin A. Ya. , Yudin B. G. , Popova O. V. , Reznik O. N. 
Published: September 2017

The first human heart transplant immediately exposed many unsolved problems of organ transplant existing at an early stage of the development of that kind of medical technology. The review of historical, legal and philosophical aspects of the first human heart transplantation in Russia and abroad is presented. Special attention is paid to the role and destiny of the pioneers of heart transplantation. The dramatic lives of Vladimir Demikhov and famous South African surgeon Christiaan Barnard are compared. The hard way of the heart transplantation founders is not lost, worthy successors continued their work, saving the lives of hundreds and thousands of patients.
Modern outlook on morphological criteria of organ and tissue decellularization
Authors: Sotnichenko A. S. , Gubareva E. A. , Kuevda E. V. , Gumenyuk I. S. , Gilevich I. V. , Nakokhov R. Z. , Slavinskiy A. A. , Alekseenko S. N. 
Published: September 2017

A rapidly growing development of tissue engineering promotes the increasing interest in the obtainment of various decellularizedtissues and organs. Minimal quality evaluation criteria of obtained tissue engineered constructions have been previously specified. In the discussionpaper the group of authors considers the morphological methods of matrix evaluation applied by various researchers on the model of heart decellularization. The analysis of modern literature and the authors’ own researches have shown that morphological evaluation of decellularization quality has to be complex and should consist of several stages which include both basic and additional evaluation methods.
Editorial
Authors: Santos Gildenir Carolino 
Published: September 2017

É com a imensa satisfação que lançamos mais um fascículo corrente do periódico: ETD – Educação Temática Digital. Costumeiramente, nos deparamos com a questão: O que é necessário para produzir um bom periódico? Automaticamente chegamos a uma resposta: basta possuir uma equipe editorial, e manter uma parceria com autores e colaboradores que queiram compartilhar seus conhecimentos e sabiamente publicar seus trabalhos num veículo de comunicação reconhecido pela comunidade.
Study on partial replacement of groundnut shell ash with cement
Authors: Lakshmi Nadiminti Venkata , Sagar Polinati Satya 
Published: September 2017

Concrete plays a prominent role in the construction industry. In the present scenario, there is a shortage of this material so there is a need to find alternatives to replace it in the concrete. In order to overcome this situation; many waste products which are available freely like a paper waste, red mud, rice husk and plastic waste can be used. Among all of these, Ground nut shell ash is one of the good waste materials available from the oil industry. It can be used widely for the replacement of cement. The ground net shell contains CaO, SiO2, Al2O3, and Fe2O3. This experimental investigation was carried out to evaluate the strength of concrete, in which cement was replaced with ground nut shell ash for cubes, cylinders, and Prisms with different percentages which vary from 0% to 30% at an interval of 5% were performed. Concrete was batched by weight on adopting a ratio of 1:2:4 with water–cement ratio of 0.6. Concrete cubes of 150*150*150 mm in dimensions, cylinders of 150*300 mm in dimensions and 100*150 mm prisms are used. These Cubes, cylinders, and prisms were tested for 7, 14 and 28 days for compression, flexural and split tensile strengths. It is observed that 10% replacement of ground nut shell ash shown the highest strength values when compared with other percentages and for 15% replacement of ground nut shell ash the compressive and split tensile strength obtained the highest strength rather than other flexural strength.
Reflecting On Practice: Embedding Student Engagement Through Interdepartmental Partnership
Authors: McConnell Catherine 
Published: September 2017

This case study will reflect on the approach that the University of Brighton Student Engagement Group (SEG) has taken towards embedding student engagement across the University and through working together on the national REACT project. The SEG comprises colleagues from Engagement and Information (Quality), the Centre for Learning and Teaching and the Students’ Union. Working together - and bringing individual areas of specialism to this partnership - has provided both a productive approach to a range of aspects of student engagement and connected three areas of the university that previously did not have a joined-up approach. The types of activities the group has focused on include: recruiting School-based Student Engagement Champions; holding a Student Engagement staff away-day; attending local meetings with Champions to establish rapport and get a good idea of the context of student engagement and who the ‘hard-to-reach’ students are within each School. This paper situates the engagement of students in co- and extra-curricular activities, towards improving opportunities for students’ active participation, and student-staff collaboration.
Effect of Frequent Well Shut-In's on Well Productivity: Marcellus Shale Case Study
Authors: Sinha Saurabh , Marfurt Kurt J. , Deka Bhabesh 
Published: September 2017

Abstract
Well operation is one of the key foundations for optimal production of hydrocarbons from unconventional shale plays. However, optimal production practices do not follow the versatility of "one size fits all" phenomenon. Completion strategy, Pressure-Volume-Temperature (PVT) properties and petrophysical properties vary from play to play. Hence, the well operating practices should be custom tailored to suit the completion and fluid properties.
In this paper, we propose optimal shut-in practices for dry gas shale reservoirs. We elaborated our study from a Marcellus shale dataset. Marcellus shale dry gas window has in place fluid properties that differ from liquid rich reservoirs like Eagle Ford and Wolfcamp shales. Therefore, production best practices borrowed "as-is" from liquid rich reservoirs and applied to dry gas reservoirs (or vice versa) may not affect the well ultimate recoveries in a positive manner and in some cases, may even reduce the expected ultimate recoveries (EUR's).
We show that the practice of "well conditioning", "resting" or "soak-in" i.e. shutting in the well for a significant time after hydraulic fracturing and before connecting to pipeline as well as frequent shut-in impedes the water unloading from the dry gas reservoirs. This leads to reduction in matrix permeability with an additional skin introduced by water imbibition.
Our methodology by simultaneously history matching gas rate, flowing bottomhole pressure (FBHP) and water rates in a reservoir simulator. We observe that after shut-in, water to gas ratio (WGR) decreases and gas rate increases. However, this increased gas rate is accompanied with higher declines in rates and pressures and ultimately leads to lower EUR's. The reduction in EUR in our case is modeled as a function of water saturation increase in the matrix due to imbibition. Thus, EUR in our study is a function of duration of shut-in and the time in well life at which the shut-in occurs.
Integration of Core Analysis, Pumping Schedule and Microseismicity to Reduce Uncertainties of Production Performance of Complex Fracture Networks for Multi-Stage Hydraulically Fractured Reservoirs
Authors: Niu Geng , Sun Jianlei , Parsegov Sergei , Schechter David 
Published: September 2017

Abstract
Microseismicity is a physical phenomenon which allows us to estimate the production capability of the well after hydraulic fracturing (HF) in a naturally fractured (NF) reservoir. Some of the microseismic events are reactivations of NFs induced by a direct hit of HF, while others are induced by the fluid leak-off from the previous stages or by elastic waves emitted into the reservoir with hydraulic fracture plane propagation. The former NFs have a chance to be propped there as the latter will not significantly increase their contribution to the production. Identification of such microseismic events helps to reduce uncertainty in the description of fracture network geometry.
Based on inferred data from core analysis NF densities and orientations, we generated multiple realizations of the semi-stochastic Discrete Fracture Network (DFN). In order to constrain them, we used time evolution of microseismic cloud in addition to results of core analysis. Fluid and proppant pumping schedule is used to identify such microseismic events because they should be located close to the pressure diffusion front generated by hydraulic fluid. Events outside of proposed region may be triggered by other factors, such as stress-strain relaxation from other stages and correspondent fractures. In most cases, they are not wide enough to take proppant from the main HF. This approach was used to reduce range of production for DFN realizations.
This workflow is implanted to a 15-stage hydraulic fracture treatment on a horizontal well placed in a siltstone reservoir with intrinsic fractures. The spatio-temporal dynamics of microseismic events are classified into two groups by the front of nonlinear pressure diffusion caused by 3-dimensional hydraulic fracturing, considered as effective and ineffective events. DFNs with only effective microseismicity and with all the induced events are generated. Then, two types of DFN related uncertainties on production are performed to evaluate the impact of filtration. Results of aleatory uncertainty quantification caused by the randomness of DFN modeling indicate the filtered events can generate a production DFN with a more consistent connected fracture area. Moreover, sensitivity analysis caused by lack of accuracy in natural fracture characterization shows the production area of DFN with filtration process is more insensitive to the variation of fracture parameters. Finally, a history match with production data and pressure data indicates this DFN model properly represents the reservoir and completion.
Our methodology characterizes well the conductive fracture network utilizing core data, microseismic data, and pumping schedule. It could restore the true productivity of each fractured stage from a massive microseismic cloud, which helps understand the contribution of fracturing job right after the treatment.
A Fast Method to Forecast Shale Pressure Depletion and Well Performance Using Geomechanical Constraints - Application to Poro-Elasticity Modeling to Predict Mid and Far Field Frac Hits at an Eagle Ford and Wolfcamp Well
Authors: Khodabakhshnejad Arman , Aimene Yamina , Mistry Nirav , Bachir Aissa , Ouenes Ahmed 
Published: September 2017

Abstract
The production from a hydraulically fractured unconventional well depends on the stimulated permeability and its interaction with the naturally fractured background permeability. Since the propagation of a hydraulic fracture is often asymmetric and depends on geomechanical factors, the ensuing pressure depletion and the EUR depends on this asymmetric behavior. An analytical asymmetric tri-linear model to approximate pressure depletion is presented. The model uses asymmetric frac design results as input and estimates the pressure depletion around a parent well. This new approach represents an acceptable alternative to full reservoir simulation when investigating frac hits problems.
This asymmetric tri-linear model was combined with our poro-elastic geomechanical modeling simulator in order to capture the physics created by the depleted pressure sink zone. This physics combines the stimulation operations in the neighboring infill well and their interactions with the complex local and far scale geologic features such as natural fractures and faults.
The pressure depletion determined at an Eagle Ford well using the asymmetric tri-linear model was similar to those found with a full reservoir simulator. Hydraulic fracture modeling of a child well located in the vicinity of a parent well with a pressure depleted zone highlighted the potential of developing a frac hit if geological features in the area were creating fluid and pressure conduits. A similar observation is made for a Wolfcamp well where a fault affected the nearby stage causing interference between potential stacked wells.
The integration of the asymmetric tri-linear model and our geomechanical simulator presents the necessary completion modeling tool to quickly, yet accurately design hydraulic fracturing while preventing frac hits, especially now with the increasing of number of infill unconventional wells.
Espiral da Aprendizagem Docente: compreensão de egressos acerca de tornar-se professor (Teacher Learning Spiral: the comprehension of graduates about the process of becoming a teacher)
Authors: MARQUEZAN FERNANDA FIGUEIRA , Morosini Marília Costa 
Published: September 2017

Apresenta-se a Espiral da Aprendizagem Docente, constituída a partir da compreensão de egressas do Programa Institucional de Bolsas de Iniciação à Docência (PIBID), sobre o seu processo de formação no curso de Pedagogia de uma IES comunitária e filantrópica do sul do país. A metodologia, de abordagem qualitativa, e a análise dos dados ancoram-se na Análise Textual Discursiva sobre entrevistas e documentos oficiais nacionais e institucionais. Foram identificadas as categorias de Prática Reflexiva como Elemento Estruturante da Aprendizagem Docente, Multiplicidade de Saberes Necessários à Docência, Interlocução Teoria-Prática e Ser Professora: Desenvolvimento Profissional Docente. Chegou-se ao entendimento de que, na medida em que as experiências vivenciadas pelas egressas nas práticas de iniciação à docência foram sendo [re]elaboradas e [res]significadas, por meio de ações concretas de situações de aprendizagem na realidade escolar, as licenciandas [re]construíram o processo de tornar-se professor. Assim, entende-se que o PIBID contribui com a aprendizagem docente, constitui-se em um programa para formação inicial de professores, proporcionando aos estudantes diferentes interpretações sobre o que significa ser professor. Palavras-chave: Educação superior. Aprendizagem docente. PIBID. Formação de professores.
XÁC ĐỊNH CÁC GEN SINH ĐỘC TỐ CỦA VI KHUẨN E. COLI PHÂN LẬP TỪ LỢN CON BỊ TIÊU CHẢY
Authors: Hòa Nguyễn Xuân , Phước Lê Văn , Trung Phạm Quang , Ánh Lê Xuân , Châu Hồ Lê Quỳnh 
Published: September 2017

Nghiên cứu về gen sản sinh độc tố STa, STb, LT, VT2e của các chủng vi khuẩn E. coli phân lập được trên địa bàn Thừa Thiên Huế cho kết quả như sau: Với mẫu bệnh phẩm là tim tỷ lệ dương tính với một trong các yếu tố độc lực là 4/6 (66,67%), bệnh phẩm ruột 3/6 (50%) và bệnh phẩm phân 20/49 (40,82%). Tỷ lệ vi khuẩn E. coli mang gen LT cao nhất 25/61 (40,98%), kế tiếp là vi khuẩn E. coli mang gen STb 18/61 (29,51%) và vi khuẩn E. coli mang gen STa 9/61 (14,75%) sau cùng là vi khuẩn E. coli mang gen sản sinh độc tố dung huyết VT2e 6/61(9,84%). Gen STa/STb số lượng 2/25 (chiếm tỷ lệ 8%), STa/LT 4/25 (chiểm tỷ lệ 16%), STa/VT2e số lượng 3/25 (chiếm tỷ lệ 12%). Trong tổ hợp 2 gen cao nhất là STb/LT 9/25 (chiếm tỷ lệ 36%). Tổ hợp 3 gen gồm có: STa/STb/VT2e 1/25 (chiếm tỷ lệ 4%), STa/LT/VT2e 1/25 (chiếm tỷ lệ 4%), cao nhất là STb/LT/VT2e 2/25 (chiếm tỷ lệ 8%). Tần suất hiện khuẩn lạc mang gen STb (0,43), LT (0,36).
KIỂM TRA KHÁNG THỂ KHÁNG TOXOPLASMA GONDII TRONG HUYẾT THANH NGƯỜI VÀ GIA SÚC TẠI THỪA THIÊN HUẾ
Authors: Lân Đinh Thị Bích , Chương Huỳnh Văn 
Published: September 2017

Chúng tôi đã kiểm tra kháng thể kháng Toxoplasma gondii trong huyết thanh người và gia súc trên địa bàn tỉnh Thừa Thiên Huế. Kết quả nghiên cứu cho thấy: - Ở người, tỷ lệ huyết thanh cho kết quả dương tính biến động từ 8 đến 30%, tùy thuộc vào việc người có tiếp xúc thường xuyên với gia súc hay không. - Ở heo, tỷ lệ huyết thanh cho kết quả dương tính thay đổi từ 10% đến 63%, tùy thuộc vào phương thức chăn nuôi heo và mèo có tiếp xúc thường xuyên với heo, thức ăn heo hay không. - Tỷ lệ huyết thanh cho kết quả dương tính của mèo nuôi ở thành phố và nông thôn tương ứng là 33 và 87%.
ĐA DẠNG SINH HỌC ĐỘNG VẬT KHÔNG XƯƠNG SỐNG CỠ LỚN VÀ GÓP PHẦN BỔ SUNG THÀNH PHẦN LOÀI THÂN MỀM (CHÂN BỤNG VÀ HAI MẢNH VỎ) Ở SÔNG HƯƠNG, CHẢY QUA ĐỊA PHẬN THÀNH PHỐ HUẾ
Authors: Trung Hoàng Đình , Ba Võ Đình , Qúy Võ Văn , Thuận Nguyễn Duy 
Published: September 2017

Bài báo này công bố kết quả điều tra tổng hợp về thành phần loài động vật không xương sống cỡ lớn và góp phần bổ sung mới các loài thuộc lớp Chân bụng (Gastropoda) và Hai mảnh vỏ (Bivalvia) của ngành Thân mềm (Mollusca). Cho đến nay đã xác định được 82 loài động vật không xương sống cỡ lớn ở sông Hương thuộc 65 giống, 36 họ, 13 bộ và 7 lớp. Bộ Mesogastropoda ưu thế nhất về loài với 23 loài (chiếm 28,05%), tiếp đến là bộ Veneroida có 11 loài (chiếm 13,41%), bộ Odonata có 10 loài (chiếm 12,20%), bộ Basommatophora và bộ Decapoda có cùng 7 loài (chiếm 8,54%), bộ Ephemeroptera có 6 loài (chiếm 7,32%), bộ Diptera và Coleoptera cùng có 4 loài (chiếm 4,88%), bộ Phyllodocida và Mytiloida có 3 loài (chiếm 3,66%), bộ Unionoida có 2 loài (chiếm 2,44%), hai bộ Tubificida và Arhynchobdellida mỗi bộ chỉ có 1 loài (chiếm 1,22%). Bổ sung mới cho thành phần loài Thân mềm Chân bụng và Hai mảnh vỏ ở sông Hương gồm 19 loài, 9 giống và 4 họ.