bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compressed cerebro‐cerebellar functional gradients in children and adolescents with attention‐deficit/hyperactivity disorder
Authors: Cao Qingquan , Wang Pan , Zhang Ziqian , Castellanos F. Xavier , Biswal Bharat B. 
Published: September 2024

AbstractBoth cortical and cerebellar developmental differences have been implicated in attention‐deficit/hyperactivity disorder (ADHD). Recently accumulating neuroimaging studies have highlighted hierarchies as a fundamental principle of brain organization, suggesting the importance of assessing hierarchy abnormalities in ADHD. A novel gradient‐based resting‐state functional connectivity analysis was applied to investigate the cerebro‐cerebellar disturbed hierarchy in children and adolescents with ADHD. We found that the interaction of functional gradient between diagnosis and age was concentrated in default mode network (DMN) and visual network (VN). At the same time, we also found that the opposite gradient changes of DMN and VN caused the compression of the cortical main gradient in ADHD patients, implicating the co‐occurrence of both low‐ (visual processing) and high‐order (self‐related thought) cognitive dysfunction manifesting in abnormal cerebro‐cerebellar organizational hierarchy in ADHD. Our study provides a neurobiological framework to better understand the co‐occurrence and interaction of both low‐level and high‐level functional abnormalities in the cortex and cerebellum in ADHD.
Neuropsychiatric symptoms: Risk factor or disease marker? A study of structural imaging biomarkers of Alzheimer's disease and incident cognitive decline
Authors: Guan Dylan X. , Rehman Tanaeem , Nathan Santhosh , Durrani Romella , Potvin Olivier , Duchesne Simon , Pike G. Bruce , Smith Eric E. , Ismail Zahinoor 
Published: September 2024

AbstractNeuropsychiatric symptoms (NPS) are risk factors for Alzheimer's disease (AD) but can also manifest secondary to AD pathology. Mild behavioral impairment (MBI) refers to later‐life emergent and persistent NPS that may mark early‐stage AD. To distinguish MBI from NPS that are transient or which represent psychiatric conditions (non‐MBI NPS), we investigated the effect of applying MBI criteria on NPS associations with AD structural imaging biomarkers and incident cognitive decline. Data for participants (n = 1273) with normal cognition (NC) or mild cognitive impairment (MCI) in the National Alzheimer's Coordinating Center Uniform Data Set were analyzed. NPS status (MBI, non‐MBI NPS) was derived from the Neuropsychiatric Inventory Questionnaire and psychiatric history. Normalized measures of bilateral hippocampal (HPC) and entorhinal cortex (EC) volume, and AD meta‐region of interest (ROI) mean cortical thickness were acquired from T1‐weighted magnetic resonance imaging scans. Multivariable linear and Cox regressions examined NPS associations with imaging biomarkers and incident cognitive decline, respectively. MBI was associated with lower volume and cortical thickness in all ROIs in both NC and MCI, except for EC volume in NC. Non‐MBI NPS were only associated with lower HPC volume in NC. Although both of the NPS groups showed higher hazards for MCI/dementia than No NPS, MBI participants showed more rapid decline. Although both types of NPS were linked to HPC atrophy, only NPS that emerged and persisted in later‐life, consistent with MBI criteria, were related to AD neurodegenerative patterns beyond the HPC. Moreover, MBI predicted faster progression to dementia than non‐MBI NPS.
Evaluating hydrological responses of satellite precipitation products over an Indian tropical catchment through a distributed physical model
Authors: Kalura Praveen , Pandey Ashish , Chowdary V. M. , Dayal Deen 
Published: September 2024

AbstractSignificant advancements in satellite‐based precipitation retrieval algorithms have led to the development of continuous, quasi‐global precipitation products, offering unique opportunities for hydrometeorological and climate research. In this context, six satellite‐based precipitation products (SPPs), including CHIRPS, CMORPH, GSMaP, IMERG, MSWEP, and PERSIANN, were thoroughly investigated for their application in hydrological simulations over the Wardha River basin in India. The observed gridded precipitation product developed by India Meteorological Department (IMD) has been used as reference data to evaluate the performance of SPPs. Hydrological variables such as runoff, soil moisture (SM) and evapotranspiration (ET) were simulated using the Variable Infiltration Capacity model. The performances of SPPs are critically assessed using various statistical metrics, including Pearson's correlation coefficient (R), Klinga‐Gupta Efficiency (KGE), Percent Bias (PBIAS), root mean square error (RMSE), and the RMSE to standard deviation ratio (RSR). The model‐simulated discharge was compared with streamflow observations at a single gauging site, while a spatially distributed comparison was conducted between simulated SM and ET and satellite‐based SM and ET. The IMD dataset consistently shows superior performance for discharge simulation at both daily and monthly scales, with KGE values of 0.85 and 0.91, respectively. Among SPPs, MSWEP and CHIRPS excel in simulating daily and monthly discharge, respectively. For ET simulation, CHIRPS outperforms IMD and other SPPs, achieving an overall KGE value of 0.37. In contrast, PERSIANN is the most effective for simulating SM compared to other precipitation products.
Application of adhesives in the treatment of cartilage repair
Authors: Feng Haoyang , Ang Kai , Guan Pengfei , Li Junji , Meng Huan , Yang Jian , Fan Lei , Sun Yongjian 
Published: September 2024

AbstractFrom degeneration causing intervertebral disc issues to trauma‐induced meniscus tears, diverse factors can injure the different types of cartilage. This review highlights adhesives as a promising and rapidly implemented repair strategy. Compared to traditional techniques such as sutures and wires, adhesives offer several advantages. Importantly, they seamlessly connect with the injured tissue, deliver bioactive substances directly to the repair site, and potentially alleviate secondary problems like inflammation or degeneration. This review delves into the cutting‐edge advancements in adhesive technology, specifically focusing on their effectiveness in cartilage injury treatment and their underlying mechanisms. We begin by exploring the material characteristics of adhesives used in cartilage tissue, focusing on essential aspects like adhesion, biocompatibility, and degradability. Subsequently, we investigate the various types of adhesives currently employed in this context. Our discussion then moves to the unique role adhesives play in addressing different cartilage injuries. Finally, we acknowledge the challenges currently faced by this promising technology.
Relational processes of cultural humility in counseling: A structural equation modeling study
Authors: Zhu Peitao , Luke Melissa M. , Wang Qiu , Liu Yanhong 
Published: September 2024

AbstractThe relational nature of cultural humility (CH) has been evident since the beginning of its conceptual and empirical explorations in multicultural counseling. However, few studies have intentionally used a theory‐driven framework to examine the relational processes of CH. In the current study, we used a structural equation modeling approach to examine the relationships between CH, empathy, therapeutic working alliance, and real relationship through a common factors framework. Using a sample of 610 adult counseling clients, we found that CH accounted for approximately 60% of the variance in the working alliance and 58% of the variance in the real relationship. Moreover, we found that empathy partially mediated the dispositional and situational effects of CH on both relational outcomes. We discussed strategies to cultivate CH in counseling relationships. We also recommended future researchers identify other theoretically related mediators and moderators.
The activity of the quorum sensing regulator HapR is modulated by the bacterial extracellular vesicle (BEV)‐associated protein ObfA of Vibrio cholerae
Authors: Ebenberger Stephan P. , Cakar Fatih , Chen Yi‐Chi , Pressler Katharina , Eberl Leo , Schild Stefan 
Published: September 2024

AbstractVibrio cholerae, a facultative human pathogen and causative agent of the severe diarrheal disease cholera, transits between the human intestinal tract and aquatic reservoirs. Like other bacterial species, V. cholerae continuously releases bacterial extracellular vesicles (BEVs) from its surface, which have been recently characterised for their role during in vivo colonisation. However, between epidemic outbreaks, V. cholerae persists in the biofilm mode for extended periods in aquatic reservoirs, which enhances environmental fitness and host transition. In this study, we investigated the effect of V. cholerae BEVs on biofilm formation, a critical feature for ex vivo survival. In contrast to BEVs from planktonic cultures, our results show that physiological concentrations of BEVs from dynamic biofilm cultures facilitate V. cholerae biofilm formation, which could be linked to a proteinaceous factor. Comparative proteomic analyses of planktonic‐ and biofilm‐derived BEVs identified a previously uncharacterised outer membrane protein as an abundant component of dynamic biofilm‐derived BEVs, which was found to be responsible for the BEV‐dependent enhancement of biofilm production. Consequently, this protein was named outer membrane‐associated biofilm facilitating protein A (ObfA). Comprehensive molecular studies unravelled ObfA as a negative modulator of HapR activity. HapR is a key transcriptional regulator of the V. cholerae quorum sensing (QS) cascade acting as a potent repressor of biofilm formation and virulence. Consistently, obfA mutants not only exhibited reduced biofilm production but also reduced colonisation fitness. Surprisingly, our results demonstrate that ObfA does not affect HapR through the canonical QS system but via the Csr‐cascade altering the expression of the small regulatory RNAs CsrC and CsrD. In summary, this study elucidates a novel intraspecies BEV‐based communication in V. cholerae that influences biofilm formation and colonisation fitness via a new regulatory pathway involving HapR, Csr‐cascade and the BEV‐associated protein ObfA.
Maintaining psychological well‐being when living at risk of Huntington's disease: An interpretative phenomenological analysis
Authors: Cooper Hollie , Simpson Jane , Dale Maria , Eccles Fiona J. R. 
Published: September 2024

AbstractLiving at risk of a genetically inherited disease can be a challenging experience causing psychological distress as well as the possibility of the genetic disease leading to physical health problems. Huntington's disease (HD) is a genetic, neurodegenerative condition. It causes motor dysfunction, cognitive decline and, during the progression of the disease, different psychological difficulties are common. A total of 12 participants living at risk of HD were interviewed and interpretative phenomenological analysis methodology was used to understand their experiences of maintaining psychological well‐being. This resulted in three themes: (1) “you're constantly in limbo”: living in two worlds; (2) “I have to live, just bloody live”: managing the possibility of a time‐limited lifespan; and (3) “I try and try my hardest to look past the disease”: the exhausting quest to keep living well. The findings indicated a need for improved knowledge within professional settings, such as for family doctors, counselors, and other health professionals, specific strategies that genetic counselors can use to support this group, and provision of accessible support and implementation of systemic interventions that would offer support for psychological coping strategies and communication around well‐being to the individual and their family unit. Future research could contribute to the formation of such knowledge and the provision of HD‐aligned services to help support the psychological well‐being of people living at risk of HD.
Endoscopic assessment of minor papilla morphology: Predictors of successful cannulation and procedural pancreatitis risk in minor papilla endotherapy
Authors: Kuraishi Yasuhiro , Nakamura Akira , Kondo Shohei , Yanagisawa Takumi , Horiuchi Ichitaro , Minamisawa Masafumi , Sasaki Nobukazu , Iwaya Yugo , Nagaya Tadanobu , Umemura Takeji 
Published: September 2024

AbstractBackgroundWe evaluated for predictors of successful cannulation and post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in minor papilla endotherapy (MPE), emphasizing endoscopic minor papilla morphology.MethodsWe retrospectively analyzed 232 MPEs in 65 patients, assessing minor papilla morphology based on three features: bulge as “prominent” or “subtle,” mucosal appearance as “papilla‐like” resembling the main papilla or “SMT‐like” akin to a gastrointestinal submucosal tumor, and orifice visibility as “clear” or “unclear.” Cannulation success was evaluated in 65 enrolled patients, with PEP risk assessed in all 232 MPEs.ResultsMinor papilla morphology was categorized as prominent/subtle bulge in 42/23 patients, papilla‐like/SMT‐like mucosal appearance in 42/23, and clear/unclear orifice visibility in 24/41. Cannulation succeeded in 54/65 patients (83%). A papilla‐like appearance and clear orifice visibility was significantly associated with cannulation success. PEP incidence was 5.2% and predominantly mild. A papilla‐like appearance significantly decreased PEP incidence, while precutting technique and orifice dilation significantly increased PEP risk.ConclusionEvaluating minor papilla morphology may help predict cannulation success and PEP risk in MPE. A papilla‐like mucosal appearance prognosticates cannulation success and reduced PEP risk, with clear orifice visibility serving as a success predictor. These findings provide practical guidance for preprocedural planning by emphasizing the importance of minor papilla morphology evaluation.
Evaluation of early treatment with intravenous idursulfase and intrathecal idursulfase‐IT on cognitive function in siblings with neuronopathic mucopolysaccharidosis II
Authors: Muenzer Joseph , Burton Barbara K. , Harmatz Paul , Gutiérrez‐Solana Luis González , Ruiz‐Garcia Matilde , Jones Simon A. , Guffon Nathalie , Inbar‐Feigenberg Michal , Bratkovic Drago , Rust Stewart , Hale Michael , Wu Yuna , Yee Karen S. , Whiteman David A. H. , Alexanderian David 
Published: September 2024

AbstractMucopolysaccharidosis II (MPS II; Hunter syndrome; OMIM 309900) is a rare, X‐linked, heterogeneous lysosomal storage disease. Approximately two‐thirds of patients develop cognitive impairment, which is difficult to assess in clinical trials, partly owing to the variable nature of cognitive impairment. Analyzing data from siblings can help to minimize this heterogeneity. We report analyses of cognitive function from siblings with MPS II enrolled in clinical trials: a natural history study (NCT01822184), a randomized, open‐label, phase 2/3 study of intravenous (IV) idursulfase with or without intrathecal idursulfase (idursulfase‐IT; NCT02055118), and its extension (NCT2412787). Cognitive function was assessed using Differential Abilities Scales, Second Edition General Conceptual Ability (DAS‐II GCA) scores; Bayley Scales of Infant and Toddler Development, Third Edition; and Vineland Adaptive Behavior Scales, Second Edition Adaptive Behavior Composite (VABS‐II ABC). Seven sets of siblings (six pairs and one set of three) were included. All patients received IV idursulfase and 10 received subsequent idursulfase‐IT. Younger siblings initiated IV idursulfase at an earlier age than their older sibling(s) in six of the sets; the younger sibling started treatment before 1 year of age in three sets. Monthly idursulfase‐IT was generally associated with a stabilization of cognitive function: DAS‐II GCA and VABS‐II ABC scores were higher at age‐matched assessments in the majority of those who either received idursulfase‐IT earlier than their sibling or who received idursulfase‐IT versus no idursulfase‐IT. These data suggest that early initiation of intrathecal enzyme replacement therapy may stabilize or slow cognitive decline in some patients with neuronopathic MPS II.
Development and characterization of fibrous high moisture extrudates based on pea protein isolate and whey protein
Authors: Zhang Jie , Yuan Jingyi , Han Xunze , Li Quanhong , Liao Xiaojun , Zhao Jing 
Published: September 2024

AbstractBACKGROUNDConstruction of meat analogs based on pea protein isolate (PPI) alone by high moisture extrusion (HME) is diffocult as a result of the lack of anisotropic structures. In the present study, 0%–15% of whey protein (WP) was introduced to PPI to make hybrid blends, which were used to construct HME extrudates.RESULTSWP enhanced the hardness, adhesive, cohesiveness and gumminess of the extrudates and facilitated the formation of a distinct anisotropic structure of PPI. The fibrous degrees of the extrudates containing 10% and 15% WP were around 1.50. The addition of WP, which has more ‐SH groups, increased the disulfide bonds and hydrogen bonding in the extrudates, leading to a denser cross‐linked structure. Particle size distribution and Fourier transform infrared analysis showed that WP induced more compact structured aggregates and more β‐sheet structures in the extrudates. Furthermore, the higher hydration capacity of WP may also help form a dilute melt and generate a more pronounced plug flow, assisting the formation of fiber structures of PPI.CONCLUSIONThe present study demonstrates that WP is a potential modifier, which could be used to improve the structure of PPI‐based meat analogs. © 2024 Society of Chemical Industry.
Global population size and conservation priority areas for the endangered Titicaca grebe
Authors: Villar D. A. , Velásquez‐Noriega Paola , Gutiérrez Tito Edwin R. , Paca‐Condori Anahi Cosky , Moreno Terrazas Edmundo G. , Hinojosa Cárdenas Ronald , Balcón Cuno Alfredo , Villanueva Carmen , Chapman Patrick , Quispe Jhazel , Marino Jorgelina , Gosler Andrew G. 
Published: September 2024

AbstractThe Titicaca grebe (Rollandia microptera) is a poorly studied endangered species, only found in the Lake Titicaca watershed of Peru and Bolivia. Population surveys undertaken in the early twenty‐first century suggested that the species had declined in number by >70%. We conducted a population survey of the grebe between March and August 2022 in Peru and Bolivia, using both maximum entropy and Bayesian occupancy models to estimate factors affecting habitat suitability for the grebe. We conducted surveys between March and August 2022 in Peru and Bolivia. Contrary to the International Union for Conservation of Nature (IUCN) population estimates of <1,000 individuals, there are likely tens of thousands of individual grebes. The population estimation was sensitive to the type of model used. Distance from shore and fishing intensity were the most significant factors influencing grebe populations. The Reserva Nacional del Titicaca, the only protected area in the lake, covers some of the most suitable Titicaca grebe habitat across its entire range. The population of the Titicaca grebe is significantly higher than previous estimates, but we do not recommend a change to its conservation status because of the lack of conservation efforts for this species, and the long‐term risks associated with global warming and fisheries bycatch.
Play is a privilege in both humans and animals: how our recreation influences wildlife
Authors: Berger Joel , Cassidy Kira A. 
Published: September 2024

AbstractNature‐based tourism nets roughly 8 billion annual travelers globally to all regions of Earth, with many visiting around 200,000 formally protected areas. Financially well‐off tourists pay for playful activities and effects on wildlife are potentially large and relatively uncertain. Our commentary makes 3 points. First, variation in resource privileges and associated benefits characterizes not only humans but other species. Among animals, well‐nurtured populations engage in more playful and leisurely activities than do those nutritionally impoverished. Privilege depends partially on birth sites, parents, and local conditions, but for humans recreation expands with monetary advantage. Second, nature‐based tourism has 2 generalizable effects on wildlife, each involving degree of habituation. Among non‐habituated populations, local site abandonment is frequent and modulated by seasonality, individuals' physiological states, and whether recreation is motorized or not. For habituated populations, tolerance emerges to increasing recreational exposure with some populations of species learning to rely on humans to shield as a buffer against possible predation. Third, desert bighorn sheep (Ovis canadensis nelsoni) offer a robust example of the issues surrounding the effects of tourism on wildlife because of the geographically complicated relationship between recreational pursuit and wildlife on public lands of the western United States. While protected for decades, females have failed to habituate to different forms of recreation at certain sites. The result has been flight or site abandonment. Biodiversity protection at numerous scales has made strong gains but is still needed where progress is stymied by income disparities, privilege, and increasing recreation ventures.
Annual variation in attribute importance to upland game hunter satisfaction in Nebraska
Authors: Gruntorad Matthew P. , Lusk Jeffery J. , Chizinski Christopher J. 
Published: September 2024

AbstractTo sustain recreational hunting participation, we need to identify what makes a hunting experience satisfying. Merely identifying which factors are important to hunter satisfaction may be insufficient, however, as factor importance could vary across consecutive hunting seasons. Using online surveys, completed by individuals who hunted upland game in Nebraska, USA, from 2018 to 2022, we applied importance grid analysis (IGA) and penalty–reward contrast analysis (PRCA) to examine how activity‐specific factors influenced satisfaction across 5 consecutive hunting seasons. Results suggested consistent differences between the explicit (perceived importance) and implicit (performance) importance of factors for each hunting season. Factors related to seeing birds and harvest held greater implicit importance than expected based on explicit importance ratings (τ > 0.55, P < 0.05), whereas factors relating to access and other hunters held relatively lower implicit importance (τ < 0.31, P < 0.05). The PRCA method consistently identified seeing game birds as a minimum requirement to upland game hunting (penalty β < −0.26, P < 0.01). However, factors relating to harvest, access, and other hunters emerged as important only within certain seasons. Using IGA and PRCA provided valuable insights about the importance of hunters seeing game birds, and how aspects of different hunting seasons may improve satisfaction for hunters.