bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematological Parameters and Blood Cell Morphology of Male and FemaleSchizothorax (Racoma) davidi(Sauvage)
Authors: Zhu Panpan , Tang Yin , Fan Junde , Fang Jing , Peng Xi , Cui Hengmin 
Published: January 2017

AbstractThe aim of this study was to obtain a basic knowledge of the hematology ofSchizothorax (Racoma) davidi(Sauvage). The results showed that red blood cell and white blood cell counts as well as mean cellular hemoglobin concentration were significantly higher in females than in males, while mean cell volumes were significantly lower in females than in males. No significant differences were seen in other hematological parameters in relation with gender. Under light microscope, erythrocytes (mature and immature), leukocytes (neutrophils, lymphocytes, and monocytes), and thrombocytes were distinguished. Mature erythrocytes were ellipsoidal cells with oval, central nucleus. Neutrophils contained banded or segmented nuclei. Small lymphocytes had a very thin rim of basophilic cytoplasm. Monocytes often possessed vacuoles in their cytoplasm. Thrombocytes existed in several forms with relatively large nucleus surrounded by a pink‐stained or hyaline cytoplasm. The percentage of the different leukocytes revealed predominance of neutrophils and small lymphocytes, followed by monocytes and large lymphocytes. The neutrophil percentages of each stage showed that metamyelocyte accounted for the most, followed by banded neutrophils. This investigation could be used for evaluation of the health status of cultured male and femaleS. davidiand will provide early detection of clinical pathology.
Over‐expression of the molecular chaperone Hsp104 in Saccharomyces cerevisiae results in the malpartition of [PSI+] propagons
Authors: Ness Frederique , Cox Brian S. , Wongwigkarn Jintana , Naeimi Wesley R. , Tuite Mick F. 
Published: January 2017

SummaryThe ability of a yeast cell to propagate [PSI+], the prion form of the Sup35 protein, is dependent on the molecular chaperone Hsp104. Inhibition of Hsp104 function in yeast cells leads to a failure to generate new propagons, the molecular entities necessary for [PSI+] propagation in dividing cells and they get diluted out as cells multiply. Over‐expression of Hsp104 also leads to [PSI+] prion loss and this has been assumed to arise from the complete disaggregation of the Sup35 prion polymers. However, in conditions of Hsp104 over‐expression in [PSI+] cells we find no release of monomers from Sup35 polymers, no monomerization of aggregated Sup35 which is not accounted for by the proportion of prion‐free [psi‐] cells present, no change in the molecular weight of Sup35‐containing SDS‐resistant polymers and no significant decrease in average propagon numbers in the population as a whole. Furthermore, they show that over‐expression of Hsp104 does not interfere with the incorporation of newly synthesised Sup35 into polymers, nor with the multiplication of propagons following their depletion in numbers while growing in the presence of guanidine hydrochloride. Rather, they present evidence that over‐expression of Hsp104 causes malpartition of [PSI+] propagons between mother and daughter cells in a sub‐population of cells during cell division thereby generating prion‐free [psi−] cells.
Married Black men's observations of fathers' teachings about husbandhood
Authors: HURT TERA R. , SHEARS JEFFREY K. , O'CONNOR MARGARET C. , HODGE SHARON B. 
Published: January 2017

AbstractIt is important to investigate the ways in which sons learn about marriage from men, including biological fathers, male relatives, and social fathers. This study's purpose is to explore Black sons' observations of fathers' teachings about husbandhood. Semistructured interviews were conducted with 52 married Black men who participated in the Pathways to Marriage project in 2010. Findings highlighted developmental pathways and family processes related to modeling husbandhood, demonstrating trust and commitment, managing conflict, protecting and providing, displaying teamwork and partnership, showing love and affection, and imparting beliefs and values. Implications and recommendations for future studies are also discussed.
Modeling Strategic Behavior in The Competitive Newsvendor Problem: An Experimental Investigation
Authors: Feng Tianjun , Zhang Yinghao 
Published: January 2017

This study experimentally investigates ordering behavior in the competitive newsvendor problem. We consider a duopoly market setting with two identical newsvendors selling the same perishable goods in a common market. Our experimental results show that average observed orders systematically deviate from the Nash equilibrium, and exhibit a similar pull‐to‐center pattern as in the classic non‐competitive newsvendor experiments: average orders fall below the Nash equilibrium in the high‐margin condition, and above the Nash equilibrium in the low‐margin condition. More importantly, the observed orders in the duopoly market are significantly higher than that in the non‐competitive newsvendor market, even in situations where standard inventory models predict no difference. We explain the ordering behavior using a strategic experience‐weighted attraction (EWA) model, which captures players' propensities for strategic thinking in game settings. Our empirical analysis suggests that the strategic EWA model generates more accurate predictions of future ordering behavior than an existing linear adaptive model without concerning strategic thinking. Further analysis shows that individuals are heterogeneous in their propensities to be a strategic player. Our research indicates the importance of modeling strategic behavior when analyzing behavioral decisions in competitive (game) environments.
Patterns of infections, aetiological agents and antimicrobial resistance at a tertiary care hospital in northern Tanzania
Authors: Kumburu Happiness Houka , Sonda Tolbert , Mmbaga Blandina Theophil , Alifrangis Michael , Lund Ole , Kibiki Gibson , Aarestrup Frank M. 
Published: January 2017

AbstractObjectiveTo determine the causative agents of infections and their antimicrobial susceptibility at a tertiary care hospital in Moshi, Tanzania, to guide optimal treatment.MethodsA total of 590 specimens (stool (56), sputum (122), blood (126) and wound swabs (286)) were collected from 575 patients admitted in the medical and surgical departments. The bacterial species were determined by conventional methods, and disc diffusion was used to determine the antimicrobial susceptibility pattern of the bacterial isolates.ResultsA total of 249 (42.2%) specimens were culture‐positive yielding a total of 377 isolates. A wide range of bacteria was isolated, the most predominant being Gram‐negative bacteria: Proteus spp. (n = 48, 12.7%), Escherichia coli (n = 44, 11.7%), Pseudomonas spp. (n = 40, 10.6%) and Klebsiella spp (n = 38, 10.1%). Wound infections were characterised by multiple isolates (n = 293, 77.7%), with the most frequent being Proteus spp. (n = 44, 15%), Pseudomonas (n = 37, 12.6%), Staphylococcus (n = 29, 9.9%) and Klebsiella spp. (n = 28, 9.6%). All Staphylococcus aureus tested were resistant to penicillin (n = 22, 100%) and susceptible to vancomycin. Significant resistance to cephalosporins such as cefazolin (n = 62, 72.9%), ceftriaxone (n = 44, 51.8%) and ceftazidime (n = 40, 37.4%) was observed in Gram‐negative bacteria, as well as resistance to cefoxitin (n = 6, 27.3%) in S. aureus.ConclusionThe study has revealed a wide range of causative agents, with an alarming rate of resistance to the commonly used antimicrobial agents. Furthermore, the bacterial spectrum differs from those often observed in high‐income countries. This highlights the imperative of regular generation of data on aetiological agents and their antimicrobial susceptibility patterns especially in infectious disease endemic settings. The key steps would be to ensure the diagnostic capacity at a sufficient number of sites and implement structures to routinely exchange, compare, analyse and report data. Sentinel sites (hospitals) across the country (and region) should report on a representative subset of bacterial species and their susceptibility to drugs at least annually. A central organising body should collate the data and report to relevant national and international stakeholders.
Ultrasound‐guided intracardiac xenotransfusion of canine packed red blood cells and epinephrine to the left ventricle of a severely anemic cat during cardiopulmonary resuscitation
Authors: Oron Liron , Bruchim Yaron , Klainbart Sigal , Kelmer Efrat 
Published: January 2017

AbstractObjectiveTo describe the use of an ultrasound‐guided intracardiac xenotransfusion of canine packed red blood cells (pRBC) to the left ventricle of a severely anemic cat during cardiopulmonary resuscitation (CPR).Case SummaryAn 8‐year‐old previously healthy neutered female cat was presented with severe weakness after she had disappeared for 1 month. On presentation, the cat was in hypovolemic shock, laterally recumbent, and severely anemic with massive flea infestation. Within minutes of admission, the cat became agonal and suffered cardiopulmonary arrest. CPR was immediately initiated; however, attempts to gain IV access during CPR were unsuccessful. As the cat's blood type was yet unknown, 10 mL of canine pRBC was transfused directly into the left ventricular chamber using ultrasound guidance, as well as 0.02 mg/kg of epinephrine using a similar technique. The cat regained cardiac activity and once the jugular vein was cannulated it received 20 additional mL of canine pRBC intravenously. The packed cell volume and total plasma protein following the intracardiac transfusion were 0.09 L/L [9%] and 30 g/L [3.0 g/dL], respectively. Subsequent blood typing revealed the cat had type B blood. The cat was discharged 3 days post‐CPR and was alive and doing well 3 months following discharge.New or Unique Information ProvidedThis is the first reported case of ultrasound‐guided intracardiac canine‐to‐feline xenotransfusion during CPR.
The consequences of avian ocular trauma: histopathological evidence and implications of acute and chronic disease
Authors: Moore Bret A. , Teixeira Leandro B. C. , Sponsel William E. , Dubielzig Richard R. 
Published: January 2017

AbstractObjectiveTo present a description and categorization of the histopathological lesions in avian ocular trauma.Animal studiedSeventy‐five birds diagnosed with ocular trauma at to the Comparative Ocular Pathology Laboratory of Wisconsin.ProceduresHistological slides were reviewed, and the type of trauma was classified by cause into either (i) blunt trauma or (ii) penetrating trauma and by duration into (i) acute or (ii) chronic.ResultsBlunt trauma was the most common source of trauma, and the most frequent lesions were observed in the retina (91%), with 71% of retinas having a tear or detachment and 46% of retinas showing chronic degenerative changes. Damage to the iris/ciliary body was present in 77% of cases. Corneal (17%) and lens (31%) lesions were relatively low. Acute traumatic events had a higher prevalence of readily identifiable discrete retinal tears/detachments (64%). Nearly all cases of chronic trauma exhibited chronic retinal lesions (93.7%), as well as a greater percentage of cartilage/bone lesions (71.4%), irido/cyclodialysis (51.9%), lenticular lesions (72.7%), and corneal damage (83.3%). However, the incidence of iridocyclodialysis was roughly equivalent for acute and chronic blunt trauma.ConclusionsOcular trauma can lead to profound acute and chronic lesions within the eye. Here, we provide insight into understanding ocular damage caused by trauma, which may help future studies suggest new therapeutic options and provide insight regarding the releasability of avian wildlife.
Clinical utility of the basophil activation test for analysis of allergic transfusion reactions: a pilot study
Authors: Okamura I. , Matsuyama N. , Yasui K. , Hirayama F. , Ikeda T. 
Published: January 2017

AbstractBackground and ObjectivesIn previous studies, we demonstrated that the basophil‐activating effects of supernatants found in residual‐transfused platelet concentrates (PC‐SNs) on whole blood basophils in cases of allergic transfusion reactions (ATRs) could be assessed by the basophil activation test (BAT) in terms of allergen/IgE dependency. However, in these studies, the basophils were derived from third‐party healthy volunteers. In this study, we performed BAT using patients' own blood basophils to analyse ATRs.Materials and MethodsThe BAT was performed in two cases of severe ATRs using residual PC‐SNs and the patients' own basophils in the presence and absence of dasatinib, an inhibitor of IgE‐mediated basophil activation.ResultsIn both cases, PC‐SNs exhibited basophil‐activating activity against the patients' basophils, but not against basophils from third‐party healthy volunteers. In addition, basophil activation was inhibited in the presence of dasatinib, indicating that the basophils were activated in an allergen/IgE‐dependent manner. Of note, the basophils in Case 2, but not in Case 1, were activated by PC‐SNs from some unrelated non‐haemolytic transfusion reaction cases.ConclusionThis pilot study indicates that the BAT may be useful in clarifying the causal relationship between ATRs and transfused blood as well as in elucidating the mechanisms behind ATRs considering the allergen/IgE‐dependent pathway.
Reviewer Acknowledgements
Authors: Willianms Ellery 
Published: January 2017

Business and Management Studies (BMS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether BMS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 2, Number 1 Abdul-Kahar Adam Arash Riasi Athina Qendro Christer Thörnqvist Florin Peci Gabriela Antošová Hung-Che Wu Kenichi Shimizu Mohammad Soliman Mythili Kolluru Oleksandr Mosin Olha Komelina Olumide Olasimbo Jaiyeoba Ombretta Caldarice Rashedul Hasan Seyed Mehrdad Miraftab Zadeh Sourabh Sharma Tetiana Paientko Yu-Shou Su Zoran Mastilo Ellery Willianms Editorial Assistant On behalf of, The Editorial Board of Business and Management Studies Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA URL: http://bms.redfame.com
Reviewer Acknowledgements
Authors: Young James 
Published: January 2017

International Journal of Social Science Studies (IJSSS) would like to thank the following reviewers for reviewing manuscripts from October 9, 2012, to April 1, 2013. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether IJSSS publishes their work, appreciate the helpful feedback provided by the reviewers. Redfame Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Patricia Wiener Anna Maria Mouza Sigit D. Arifwidodo Daniele Schilirò Mariano D. Perelman Troy Lovata Mónica Martínez Gómez Remigiusz Janusz Kijak Matthew Dabros Joan Garcia Garriga Kim L. Stansbury Robert Costello Joy D. Patton Sudershan Pasupuleti Ludmila Ribeiro Gabriela Kütting Daniel Topinka Marilynne Kirshbaum Regina Kuersten-Hogan Meagan Parmley George E. Higgins
Reviewer Acknowledgements
Authors: Smith Robert 
Published: January 2017

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 4, Number 8 Brenda L. Shook Cynthia M. Compton David A. Compton Davy Seligin Elena Jerves Erickzon Astorga Fatma Ozudogru Katya De Giovanni Laima Kyburiene Puneet S. Gill Richard Penny Suzan Kavanoz Robert Smith Editorial Assistant On behalf of, The Editorial Board of Journal of Education and Training Studies Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA URL: http://jets.redfame.com
Reviewer Acknowledgements
Authors: Smith Robert 
Published: January 2017

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 4, Number 9 Abdelkader Hermas António Calha Betsy Diegel Cynthia M. Compton Dodzi Amemado Donna Smith Ebrahim Mohammadpour Elena Jerves Erickzon Astorga Fatma Ozudogru Intakhab Khan Jeyavel Sundaramoorthy Jiao Ji John Cowan Katya De Giovanni Kevin Tarlow Laima Kyburiene Lorna Enerva Mehmet Inan Min Gui Mu-hsuan Chou Niveen M. Zayed Puneet S. Gill Richard H. Martin Samad Mirza Suzani Sharma Sashi Suzan Kavanoz Robert Smith Editorial Assistant On behalf of, The Editorial Board of Journal of Education and Training Studies Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA URL: http://jets.redfame.com
Snapshot Profiling of the Antileishmanial Potency of Lead Compounds and Drug Candidates against Intracellular Leishmania donovani Amastigotes, with a Focus on Human-Derived Host Cells
Authors: Koniordou Markela , Patterson Stephen , Wyllie Susan , Seifert Karin 
Published: January 2017

ABSTRACT

This study characterized the
in vitro
potencies of antileishmanial agents against intracellular
Leishmania donovani
amastigotes in primary human macrophages, obtained with or without CD14-positive monocyte enrichment, phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 cells, and mouse peritoneal exudate macrophages (PEMs). Host cell-dependent potency was confirmed for pentavalent and trivalent antimony. Fexinidazole was inactive against intracellular amastigotes across the host cell panel. Fexinidazole sulfone, (
R
)-PA-824, (
S
)-PA-824, and VL-2098 displayed similar potency in all of the host cells tested.
SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies
Authors: Scorneaux Bernard , Angulo David , Borroto-Esoda Katyna , Ghannoum Mahmoud , Peel Michael , Wring Stephen 
Published: January 2017

ABSTRACT

SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpene antifungals in clinical development for treating candidemia and invasive candidiasis.
In vitro
susceptibilities by broth microdilution, antifungal carryover, and time-kill dynamics were determined for three reference (ATCC) strains (
Candida albicans
90028,
Candida parapsilosis
90018, and
Candida tropicalis
750), a quality-control (QC) strain (
Candida krusei
6258), and four other strains (
C. albicans
MYA-2732, 64124, and 76485 and
Candida glabrata
90030). Caspofungin (CASP), fluconazole (FLC), and voriconazole (VRC) were comparators. For time-kill experiments, SCY-078 and CASP were evaluated at 0.25, 1, 2, 4, 8, and 16 times the MIC
80
, and FLU and VRC were evaluated at 4× MIC
80
. The time to reach 50%, 90%, and 99.9% reduction in the number of CFUs from the starting inoculum was determined. Net change in the number of CFU per milliliter was used to determine 50% and 90% effective concentrations and maximum effect (EC
50
, EC
90
, and
E
max
, respectively). The SCY-078 MIC range was between 0.0625 and 1 μg/ml and generally similar to that of CASP. Antifungal carryover was not observed for SCY-078. SCY-078 was fungicidal against seven isolates at ≥4× MIC (kill of ≥3 log
10
) and achieved a 1.7-log
10
reduction in CFU count/milliliter against
C. albicans
90028. CASP behaved similarly against each isolate and achieved a 1.5-log
10
reduction in the number of CFU/milliliter against
C. albicans
90028. Reductions of 50% in CFU count/milliliter were achieved rapidly (1 to 2.8 h); fungicidal endpoints were reached at 12.1 to 21.8 h at ≥4× MIC. EC
90
was reached at ∼5× MIC at each time point to 24 h. The EC
50
and EC
90
values were generally similar (8 to 24 h). Time-kill behavior of CASP was similar to that of SCY-078. FLC and VRC were fungistatic. Overall, SCY-078 has primarily fungicidal activity against
Candida
spp. and behaved comparably to CASP.
In Vitro
Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae
Authors: Farrell D. J. , Sader H. S. , Rhomberg P. R. , Scangarella-Oman N. E. , Flamm R. K. 
Published: January 2017

ABSTRACT

Gepotidacin (formerly GSK2140944) is a novel, first-in-class, triazaacenaphthylene antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV via a unique mechanism and has demonstrated
in vitro
activity against
Neisseria gonorrhoeae
, including drug-resistant strains, and also targets pathogens associated with other conventional and biothreat infections. Broth microdilution was used to evaluate the MIC and minimum bactericidal concentration (MBC) activity of gepotidacin and comparators against 25
N. gonorrhoeae
strains (including five ciprofloxacin-nonsusceptible strains). Gepotidacin activity was also evaluated against three
N. gonorrhoeae
strains (including a ciprofloxacin-nonsusceptible strain) for resistance development, against three
N. gonorrhoeae
strains (including two tetracycline- and azithromycin-nonsusceptible strains) using time-kill kinetics and checkerboard methods, and against two
N. gonorrhoeae
strains for the investigation of postantibiotic (PAE) and subinhibitory (PAE-SME) effects. The MIC
50
and MIC
90
for gepotidacin against the 25
N. gonorrhoeae
isolates tested were 0.12 and 0.25 μg/ml, respectively. The MBC
50
and MBC
90
for gepotidacin were 0.25 and 0.5 μg/ml, respectively. Gepotidacin was bactericidal, and single-step resistance selection studies did not recover any mutants, indicating a low rate of spontaneous single-step resistance. For combinations of gepotidacin and comparators tested using checkerboard methods, there were no instances where antagonism occurred and only one instance of synergy (with moxifloxacin; fractional inhibitory concentration, 0.375). This was not confirmed by
in vitro
time-kill studies. The PAE for gepotidacin against the wild-type strain ranged from 0.5 to >2.5 h, and the PAE-SME was >2.5 h. These
in vitro
data indicate that further study of gepotidacin is warranted for potential use in treating infections caused by
N. gonorrhoeae
.