bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biobased mineral‐oil barrier‐coated food‐packaging films
Authors: Vartiainen Jari , Laine Christiane , Willberg‐Keyriläinen Pia , Pitkänen Marja , Ohra‐aho Taina 
Published: November 2016

ABSTRACTToxic mineral oils can migrate into foods from cardboard boxes made of recycled fibers. This is an emerging issue for the whole dry‐food‐packaging industry. Breakfast cereals, for example, are typically packaged in boxes with or without inner bags and consumed without further processing. Currently, fossil‐based high‐density polyethylene (HDPE) films are used as a major raw material for such inner bags. However, HDPE is a very poor barrier against mineral‐oil migration. Biobased coatings from cellulose nanofibrils (CNFs), hydroxypropylated xylan, and hydroxypropylated cellulose were applied onto biobased high‐density polyethylene (bio‐HDPE) films, and the mineral‐oil barrier properties were evaluated. All of the coated films significantly decreased the migration of n‐decane, isobutylbenzene, 1‐cyclohexylbutane, 1‐cyclohexylheptane, and 1‐cyclohexyldecane. Biobased barrier bags prepared from (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxy oxidized CNF coated bio‐HDPE film protected the content to a great extent from mineral‐oil migration compared to noncoated bio‐HDPE and other commercial breakfast cereal‐bag films. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44586.
In vitro differentiated hepatic oval‐like cells enhance hepatic regeneration in CCl4‐induced hepatic injury
Authors: Awan Sana Javaid , Baig Maria Tayyab , Yaqub Faiza , Tayyeb Asima , Ali Gibran 
Published: November 2016

AbstractHepatic oval cells are likely to be activated during advanced stage of liver fibrosis to reconstruct damaged hepatic tissue. However, their scarcity, difficulties in isolation, and in vitro expansion hampered their transplantation in fibrotic liver. This study was aimed to investigate the repair potential of in vitro differentiated hepatic oval‐like cells in CCl4‐induced liver fibrosis. BMSCs and oval cells were isolated and characterized from C57BL/6 GFP+ mice. BMSCs were differentiated into oval cells by preconditioning with HGF, EGF, SCF, and LIF and analyzed for the oval cells‐specific genes. Efficiency of oval cells to reduce hepatocyte injury was studied by determining cell viability, release of LDH, and biochemical tests in a co‐culture system. Further, in vivo repair potential of differentiated oval cells was determined in CCl4‐induced fibrotic model by gene expression analysis, biochemical tests, mason trichrome, and Sirius red staining. Differentiated oval cells expressed hepatic oval cells‐specific markers AFP, ALB, CK8, CK18, CK19. These differentiated cells when co‐cultured with injured hepatocytes showed significant hepato‐protection as measured by reduction in apoptosis, LDH release, and improvement in liver functions. Transplantation of differentiated oval cells like cells in fibrotic livers exhibited enhanced homing, reduced liver fibrosis, and improved liver functions by augmenting hepatic microenvironment by improved liver functions. This preconditioning strategy to differentiate BMSCs into oval cell leads to improved survival and homing of transplanted cells. In addition, reduction in fibrosis and functional improvement in mice with CCl4‐induced liver fibrosis was achieved.
MicroRNA‐503‐5p inhibits stretch‐induced osteogenic differentiation and bone formation
Authors: Liu Lu , Liu Mengjun , Li Rongrong , Liu Hong , Du Liling , Chen Hong , Zhang Yan , Zhang Shijie , Liu Dongxu 
Published: November 2016

AbstractCyclical stretch‐induced bone formation during orthodontic treatment is a complex biological process modulated by various factors including miRNAs and their targeted‐gene network. However, the miRNA expression profile and their roles in osteogenic differentiation of bone mesenchymal stem cells (BMSCs) exposed to mechanical stretch remains unclear. Here, we use the miRNA microarray assay to screen for mechano‐sensitive miRNAs during stretch‐induced osteogenic differentiation of BMSCs and identified that nine miRNAs were differentially expressed between stretched and control BMSCs. Furthermore, miR‐503‐5p, which was markedly downregulated in both microarray assay and qRT‐PCR assay were selected for further functional verification. We found that overexpression of miR‐503‐5p in BMSCs attenuated stretch‐induced osteogenic differentiation while the effect was reversed by miR‐503‐5p inhibition treatment. In vivo studies, overexpression of miR‐503‐5p with specific agomir decreased Runx2, ALP mRNA, and protein expression, decreased osteoblast numbers and osteoblastic bone formation in the OTM tension sides. In conclusion, our study revealed that miR‐503‐5p functions as the mechano‐sensitive miRNA and inhibits BMSCs osteogenic differentiation subjected to mechanical stretch and bone formation in OTM tension sides.
Outcomes of patients with low‐pressure aortic gradient undergoing transcatheter aortic valve implantation
Authors: Conrotto Federico , D'Ascenzo Fabrizio , D'Amico Maurizio , Moretti Claudio , Pavani Marco , Scacciatella Paolo , Omedè Pierluigi , Montefusco Antonio , Biondi‐Zoccai Giuseppe , Gaita Fiorenzo , Maisano Francesco , Nietlispach Fabian 
Published: November 2016

Background: The risk/benefit balance of transcatheter aortic valve implantation (TAVI) in patients with low‐gradient aortic stenosis (LGAS) remains to be well defined. Aim of the study was to investigate the impact of LGAS in patients undergoing TAVI.Methods: Medline, Cochrane Library, and Scopus were searched for articles reporting outcome of patients with LGAS undergoing TAVI. The primary endpoint was 12‐months all‐cause mortality and the secondary endpoint was 30‐day all‐cause mortality. Using event‐rates as dependent variable, a meta‐regression was performed to test for interaction between baseline clinical features (age, gender, diabetes mellitus, coronary artery disease, left ventricular ejection fraction (LVEF) and type of implanted valve) and transaortic gradient for the primary endpoint.Results: Eight studies with a total of 12,589 patients were included. Almost one‐third of the patients presented with LGAS (27.3%: 24.4–29.2). Median LVEF was 48% in patients with LGAS and 56% in patients with high‐gradient AS. Patients with LGAS were more likely to have diabetes mellitus, previous coronary artery disease, higher mean Logistic EuroSCORE, and lower EF. At 12 (12–16.6) months, low transaortic gradient emerged as independently associated with all‐cause death, both if evaluated as a dichotomous and continuous value (respectively OR 1.17; 1.11–1.23 and OR 1.02; 1–1.04, all CI 95%). Clinical variables, including EF did not affect this result.Conclusions: In a population of TAVI patients, LGAS appears to be independently related to dismal prognosis. © 2016 Wiley Periodicals, Inc.
One‐Dimensional Heterostructured Palladium Oxide‐Cobalt Oxide Catalyst for the Catalytic Oxidation of Methane
Authors: Sun Yongnan , Liu Jingwei , Yang Nating , Zhu Yan 
Published: November 2016

AbstractWe report a precise synthesis of heterostructured PdO‐Co3O4 nanorods through an anion exchange and recrystallization process. Such PdO‐Co3O4 nanorods have a more effective catalytic activity and long‐term stability for methane oxidation than PdO/Co3O4 catalysts obtained by conventional approaches. The excellent catalytic properties of PdO‐Co3O4 nanorods are associated with the synergetic effect between PdO and Co3O4, which not only favors the formation of superoxide species but also enhances the redox properties to provide further methane activation capabilities at low temperatures. Meanwhile, PdO embedded in the Co3O4 domain ensures structural stability and an exceptional resistance towards the sintering of the active sites under thermal conditions.
Unsaturated Four‐Membered Rings: Efficient Strategies for the Construction of Cyclobutenes and Alkylidenecyclobutanes
Authors: Eisold Michael , Baumann Andreas N. , Kiefl Gabriel M. , Emmerling Sebastian T. , Didier Dorian 
Published: November 2016

AbstractOur recent studies of the diastereo‐ and enantioselective formation of strained alkylidenecycloalkanes drove us to more‐thoroughly investigate the formation of four‐membered rings for which only few efficient methods are described. We first developed a strategy to diversify the saturated part of the four‐membered ring and applied it to a highly diastereoselective synthesis of more‐elaborate alkylidenecyclobutanes, which completed our precedent studies. In parallel, cyclobutene structures were built employing simple organometallic methods and further functionalized to give a diverse range of new substitution patterns, which consequently enriched the pool of cyclobutene‐based building blocks.
Nano Metal‐Organic Framework‐Derived Inorganic Hybrid Nanomaterials: Synthetic Strategies and Applications
Authors: Mai Hien Duy , Rafiq Khezina , Yoo Hyojong 
Published: November 2016

AbstractNano‐ (or micro‐scale) metal‐organic frameworks (NMOFs), also known as coordination polymer particles (CPPs), have received much attention because of their structural diversities and tunable properties. Besides the direct use, NMOFs can be alternatively used as sacrificial templates/precursors for the preparation of a wide range of hybrid inorganic nanomaterials in straightforward and controllable manners. Distinct advantages of using NMOF templates are correlated to their structural and functional tailorability at molecular levels that is rarely acquired in any other conventional template/precursor. In addition, NMOF‐derived inorganic nanomaterials with distinct chemical and physical properties are inferred to dramatically expand the scope of their utilization in many fields. In this review, we aim to provide readers with a comprehensive summary of recent progress in terms of synthetic approaches for the production of diverse inorganic hybrid nanostructures from as‐synthesized NMOFs and their promising applications.
Guideline‐based statin/lipid‐lowering therapy eligibility for primary prevention and accuracy of coronary artery calcium and clinical cardiovascular events: The Multi‐Ethnic Study of Atherosclerosis (MESA)
Authors: Flueckiger Peter , Qureshi Waqas , Michos Erin D. , Blaha Michael , Burke Gregory , Sandfort Veit , Herrington David , Yeboah Joseph 
Published: November 2016

BackgroundWith multiple cholesterol guidelines, we evaluated the accuracy of recommended statin therapy on identifying coronary artery calcium (CAC) and cardiovascular disease (CVD) events by 2004 NCEP/ ATP III, 2016 ESC/EAS, and 2013 ACC/AHA guidelines.HypothesisACC/AHA guidelines are more accurate in identifying persons at risk for CVD.Methods5002/6814 participants age <75 years and free of CVD were included. CAC categories (>0, ≥100, and ≥300) and 10 years of CVD outcomes were considered. Sensitivity (SN), specificity (SP), positive and negative predictive value (PPV and NPV), and likelihood ratios (LR) were calculated. Mean age was 59 years; 47% of subjects were males.Results1297 (26%), 1381 (28%), and 2538 (51%) had class I indications for statin/LLT by the NCEP ATP III, ESC/EAS, and AHA/ACC guidelines, respectively. SN, SP, NPV, and PPV for CAC ≥300 were: NCEP ATP III (41.1%, 75.5%, 93.3% and 13.4%), ESC/EAS (54.1%, 74.8%, 94.6% and16.6%), and ACC/AHA (87.2%, 52.6%, 97.8% and 14.5%). SN, SP, PPV, and NPV for corresponding CVD outcomes were: NCEP ATP III (45.8%, 75.1%, 96.3%, and 8.9%), ESC/EAS (50.5%, 72.9%, 98.7%, and 3.6%), and AHA/ACC (79.6%, 50.7%, 98%, and 7.7%). ESC/EAS had significantly higher positive LR 2.15 (95% CI, 1.95 – 2.38) and ACC/AHA had significantly lower negative LR [0.24, (95% CI 0.19 – 0.31)] for corresponding CVD.ConclusionsDespite the increased in SN of statin eligibility by the ACC/AHA, it has similar NPV and PPV for CAC/future CVD events. The ACC/AHA class I indications for statin may be a superior screening tool for subclinical and clinical CVD.
The G Protein‐Coupled Receptor GPR17: Overview and Update
Authors: Marucci Gabriella , Dal Ben Diego , Lambertucci Catia , Santinelli Claudia , Spinaci Andrea , Thomas Ajiroghene , Volpini Rosaria , Buccioni Michela 
Published: November 2016

AbstractThe GPR17 receptor is a G protein‐coupled receptor (GPCR) that seems to respond to two unrelated families of endogenous ligands: nucleotide sugars (UDP, UDP‐galactose, and UDP‐glucose) and cysteinyl leukotrienes (LTD4, LTC4, and LTE4), with significant affinity at micromolar and nanomolar concentrations, respectively. This receptor has a broad distribution at the level of the central nervous system (CNS) and is found in neurons and in a subset of oligodendrocyte precursor cells (OPCs). Unfortunately, disparate results emerging from different laboratories have resulted in a lack of clarity with regard to the role of GPR17‐targeting ligands in OPC differentiation and in myelination. GPR17 is also highly expressed in organs typically undergoing ischemic damage and has various roles in specific phases of adaptations that follow a stroke. Under such conditions, GPR17 plays a crucial role; in fact, its inhibition decreases the progression of ischemic damage. This review summarizes some important features of this receptor that could be a novel therapeutic target for the treatment of demyelinating diseases and for repairing traumatic injury.
3‐D data partitioning for 3‐level perfectly nested loops on heterogeneous distributed systems
Authors: Zarei Zefreh Ebrahim , Lotfi Shahriar , Mohammad Khanli Leyli , Karimpour Jaber 
Published: November 2016

SummaryNested loops are the largest source of parallelism in many data‐parallel scientific applications. Heterogeneous distributed systems are popular computing platforms for data‐parallel applications. Data partitioning is critical in exploiting the computational power of such systems, and existing data partitioning algorithms try to maximize performance of data‐parallel applications by finding a data distribution that balances the workload between the processing nodes while minimizing communication costs. This paper addresses the problem of 3‐dimensional data partitioning for 3‐level perfectly nested loops on heterogeneous distributed systems. The primary aim is to minimize the execution time by improving the load balancing and minimizing the internode communications. We propose a new data partitioning algorithm using dynamic programming, build a theoretical model to estimate the execution time of each partition, and select a partition with minimum execution time as a near‐optimal solution. We demonstrate the effectiveness of the new algorithm for 2 data‐parallel scientific applications on heterogeneous distributed systems. The new algorithm reduces the execution time by between 7% and 17%, on average, compared with leading data partitioning methods on 3 heterogeneous distributed systems.
The Reciprocal Relationship between Bipolar Disorder and Social Interaction: A Qualitative Investigation
Authors: Owen Rebecca , Gooding Patricia , Dempsey Robert , Jones Steven 
Published: November 2016

BackgroundEvidence suggests that social support can influence relapse rates, functioning and various clinical outcomes in people with bipolar disorder. Yet ‘social support’ is a poorly defined construct, and the mechanisms by which it affects illness course in bipolar disorder remain largely unknown. Key aims of this study were to ascertain which facets of social interaction affect mood management in bipolar disorder, and how symptoms of bipolar disorder can influence the level of support received.MethodSemi‐structured qualitative interviews were conducted with 20 individuals with bipolar disorder. Questions were designed to elicit: the effects of social interaction upon the management and course of bipolar disorder; and the impact of bipolar disorder upon social relationships. An inductive thematic analysis was used to analyse the data.ResultsEmpathy and understanding from another person can make it easier to cope with bipolar disorder. Social interaction can also provide opportunities to challenge negative ruminative thoughts and prevent the onset of a major mood episode. The loss of social support, particularly through bereavement, creates a loss of control and can trigger mania or depression. Hypomanic symptoms can facilitate new social connections, whereas disinhibited and risky behaviour exhibited during mania can cause the breakdown of vital relationships.ConclusionsAn in‐depth clinical formulation of an individual's perceptions of how their illness affects and is affected by social interaction is crucial to understanding psychosocial factors which influence mood management. These results have clear application in interventions which aim to promote improved wellbeing and social functioning in bipolar disorder. Copyright © 2016 John Wiley & Sons, Ltd.Key Practitioners Messages

The relationship between bipolar‐related experiences and social interaction is complex and multi‐faceted.
Bipolar disorder can damage social relationships and create a loss of social control via extreme mood states, but it can also offer a social advantage through elevated self‐confidence during hypomania and enhanced resilience post-recovery.
Positive social experiences can facilitate better personal coping and enhanced mood management, whilst negative social experiences can trigger the onset of acute mood episodes.
A comprehensive formulation of the reciprocal links between facets of bipolar disorder and characteristics of interpersonal relationships should be used to guide psychosocial interventions that aim to enhance emotion regulation and improve functioning.
The association of leaf lifespan and background insect herbivory at the interspecific level
Authors: Zhang Shuang , Zhang Yuxin , Ma Keming 
Published: November 2016

AbstractHerbivory is well known to be a major selective pressure that affects plant communities, but the leaf traits that mediate variations in herbivory at the interspecific level remain controversial. We collected published data on background insect herbivory and leaf traits from a wide variety of species to test the hypothesis that species with intermediate leaf lifespans, lower fiber, and higher nutrient contents in leaves should have higher levels of herbivory. We found that at the interspecific level herbivory had a hump‐shaped relationship with leaf lifespan and a positive relationship with leaf size. Surprisingly, our data show that nutritional traits have little relationship to herbivory. Our study provides new insights relevant to the recent debate on leaf trait–herbivory relationships. These findings are especially helpful in explaining the general patterns of herbivory detected on the global scale.
Ground reaction force and required friction during stair ascent and descent
Authors: Li Kai Way , Huang Szu‐Yin , Chiu Wen‐Hsin 
Published: November 2016

AbstractA stair climbing experiment was performed using a four‐stair instrumented stairway. A force platform was mounted in the first stair. Four floor surfaces, including the original force platform surface and three additional floor coverings on the platform, were tested. Human subjects wore the same type of lab shoes and ascended and descended the stairway. Their ground reaction forces were collected. The results showed that when descending, the double‐stair condition resulted in significant (p < .0001) higher vertical ground reaction force at foot landing as compared to the single‐stair condition. The vertical ground reaction force at foot push‐off for stair ascent were significantly (p < .0001) higher than those for stair descent. The mean required coefficient of friction ranged from 0.086 to 0.245 and from 0.051 to 0.246 for foot landing and foot push‐off spots, respectively. Stair descent required significant (p < .001) higher friction than stair ascent both at foot landing and push‐off. Double‐stair stepping required higher friction than single‐stair stepping. Stair descent should be of primary concern in assessing the risk of slip‐ and fall‐related incidents on stairway, and double‐stair descent should be avoided.
A possible approach to assess acidification of meat starter cultures: a case study from some wild strains of Lactobacillus plantarum
Authors: Speranza Barbara , Bevilacqua Antonio , Corbo Maria Rosaria , Sinigaglia Milena 
Published: November 2016

AbstractBACKGROUNDThe performances of four autochthonous isolates of Lactobacillus plantarum were assessed to study the most important variables acting on acidification and to propose a possible step‐by‐step approach for the validation at laboratory scale. This main topic was addressed through three intermediate steps: (1) evaluation of acidification in liquid and solid media, as a function of salt, nitrites, nitrates, lactose, pepper and temperature; (2) assessing acidification in a pork‐meat preparation; and (3) designing a protocol to improve the performances at sub‐optimal temperatures. The concentration of the ingredients and the temperature were combined through a 3k−p Fractional Factorial Design. Acidification and viable count were assessed and modelled through a multi‐factorial ANOVA.RESULTSIn model systems acidification was affected by lactose and was maximum (ΔpH of ca. 2.8–3.0) in the combinations containing 0.4% lactose, 250 mg kg−1 nitrates or 150 mg kg−1 nitrites, 5% salt, and at 30 °C. Solid media caused a higher acidification. In the pork meat preparation, the effect of salt and nitrites was significant. At 10 °C the strains could not reduce pH, but this ability could be induced using an adaptation step.CONCLUSIONAcidification was affected by lactose in the model system, whereas in meat preparation the other variables were significant. In addition, a protocol to improve acidification at 10 °C was optimised. © 2016 Society of Chemical Industry
Anisotropic thin films formation rate on PEDOT : PSS layer with high azimuthal anchoring
Authors: Stankevich Andrei , Bezruchenko Veronika , Muravsky Alexander , Murauski Anatoli , Agabekov Vladimir 
Published: November 2016

AbstractOriented organic layers have great potential for organic electronics devices because of the unique modification of material properties without extensive chemical synthesis. Such layers can be prepared by wet coating of anisotropic organic molecules on top of specific surface of alignment layer. One of the most important parameter that indicates alignment properties of the surface is the anchoring energy. In this paper, we investigate azimuthal anchoring energy of pure and glycerol‐doped PEDOT : PSS layers and study the influence of the alignment layer preparation on the order parameter of the top wet‐coated oriented organic emitter. We confirm that the azimuthal anchoring energy increase leads to improvement of both dichroic ratio and contrast ratio of polarized emitter layer rod‐coated on top of the PEDOT : PSS. Suggested mechanism of anisotropic emitter formation at wet deposition grounds possibility of linear deposition rate of 2 m/s on top of PEDOT : PSS layer with obtained azimuthal anchoring above >10−4 J/m2.