bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of musical interventions and its effect on blood pressure among United States populations: a systematic review and meta-analysis
Authors: Meda Shreya , Gyamfi Joyce , Patel Kahini , Islam Farha , Vieira Dorice , Nyame Solomon , Ruan Christina , Boradia Krupa , Chhetri Himani , Thunga Sukruthi , Adenikinju Deborah , Amesimeku Etornam , Diawara Amy , Opeyemi Jumoke , Ojo Temitope , Chirinos Carlos , Williams Olajide , Ogedegbe Olugbenga , Peprah Emmanuel 
Published: October 2024

BackgroundHypertension (HTN) currently affects over 120 million Americans, in the United States (US). Thus, the implementation of evidence-based interventions (EBI) for blood pressure (BP) reduction is pivotal in minimizing this burden. We sought to evaluate evidence from published literature on the effectiveness of musical interventions for BP reduction within the US.MethodsA systematic review of studies that utilize music interventions to manage BP was conducted in October of 2022. An extensive search of several databases utilizing MeSH terms and relevant keywords was conducted for articles published through October 2022. An updated search was conducted in October 2023 to identify additional studies.Results2,381 studies were screened for title/abstract relevancy. 1,885 studies were deemed irrelevant, and 495 studies were examined for full-text review; of which 384 were excluded due to being non-US-based. Overall, 25 studies were found where BP was the primary outcome and discussed musical interventions within the US. Of the 25 studies, 72% reported a significant decrease in BP after the administration of a musical intervention and only 28% reported the race and ethnicity of participants.ConclusionThere are limited studies that examine the effect of music interventions on BP reduction in the US, as a primary outcome. However, based on the evidence, musical interventions are effective for BP reduction. Moreover, the studies that were conducted in the US include a low percentage of high-risk racial and ethnic minority populations. Future EBI should target this underserved/high-burden group to improve disparity gaps within BP reduction via non-pharmacological means.Systematic Review RegistrationOpen Science Framework,doi: 10.17605/OSF.IO/4G3EB.
Strategic cultivar and sowing time selection for weed management and higher redgram productivity in semi-arid Indian regions
Authors: Marimuthu S. , Byrareddy Vivekananda M. , Dhanalakshmi A. , Mushtaq Shahbaz , Surendran U. 
Published: October 2024

IntroductionRedgram (Cajanus cajan L. Mill sp.), a leguminous crop commonly grown in tropical and subtropical climates, is highly valued for its high protein content (21%), which contributes significantly to food and nutritional security. However, its production faces challenges primarily due to terminal dryness experienced during critical growth stages because of changing rainfall patterns. To overcome this, adaptive techniques become imperative as the productivity of this crop is intricately linked to environmental factors and the crop’s growth cycle.MethodsHence, the field experiment was conducted at the National Pulses Research Centre, Vamban, Pudukkottai, Tamil Nadu, in South India under rainfed condition, during the kharif (monsoon) seasons of 2017–18 and 2018–19. The primary objectives were to determine the optimal sowing time and identify suitable redgram cultivars, especially in the context of the late onset of the monsoon in Tamil Nadu, a common issue under changing climate conditions. The experiments tested six different sowing dates with three redgram cultivars.Results and discussionThe findings highlighted the substantial influence of different redgram cultivars and sowing times on the crop’s growth characteristics and yield. Among the six sowing dates tested, planting in later half of June (S6) resulted in notably higher plant height (201 cm), a greater number of pods per plant (287), a seed yield of 1,112 kg ha−1, and a benefit-cost ratio of 2.61 Notably, this sowing period (S6) demonstrated comparable performance with the treatment of redgram sowing in the latter part of September (S4). CO 6 (V1) is the most productive of the three redgram cultivars, with the highest mean pant height (200 cm), number of pods per plant (237), grain yield (1,017 kg ha−1), and benefit cost ratio (2.38). Extended phenological phases along with extra days to reach phenological stages could account for the increased yield in comparison to the other cultivars. Among the two short-duration cultivars, VBN (Rg) 3 (V3) had a significantly higher mean grain yield of 958 kg ha−1 with the benefit-cost ratio of 2.24. Even though CO 6 (V1) obtained a higher yield due to its long duration nature, it matured in 187 days whereas VBN (Rg) 3 (V3) matured within 129 days. Consequently, the short-duration redgram cultivars emerge as highly suitable choices for integrating into crop sequences, thereby augmenting farm cropping intensity.
Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response
Authors: Santos Patrick , Rezende Caroline P. , Piraine Renan , Oliveira Bianca , Ferreira Francielle B. , Carvalho Vinicius S. , Calado Rodrigo T. , Pellegrini Matteo , Almeida Fausto 
Published: October 2024

IntroductionBreast cancer is a significant public health problem around the world, ranking first in deaths due to cancer in females. The therapy to fight breast cancer involves different methods, including conventional chemotherapy. However, the acquired resistance that tumors develop during the treatment is still a central cause of cancer-associated deaths. One mechanism that induces drug resistance is cell communication via extracellular vesicles (EVs), which can carry efflux transporters and miRNA that increase sensitive cells’ survivability to chemotherapy.MethodsOur study investigates the transcription changes modulated by EVs from tamoxifen- and doxorubicin-resistant breast cancer cells in sensitive cells and how these changes may induce acquired drug resistance, inhibit apoptosis, and increase survivability in the sensitive cells. Additionally, we exposed human macrophages to resistant EVs to understand the influence of EVs on immune responses.ResultsOur results suggest that the acquired drug resistance is associated with the ability of resistant EVs to upregulate several transporter classes, which are directly related to the increase of cell viability and survival of sensitive cells exposed to EVs before a low-dose drug treatment. In addition, we show evidence that resistant EVs may downregulate immune system factors to evade detection and block cell death by apoptosis in sensitive breast cancer cells. Our data also reveals that human macrophages in contact with resistant EVs trigger a pro-inflammatory cytokine secretion profile, an effect that may be helpful for future immunotherapy studies.DiscussionThese findings are the first transcriptome-wide analysis of cells exposed to resistant EVs, supporting that resistant EVs are associated with the acquired drug resistance process during chemotherapy by modulating different aspects of sensitive cancer cells that coffer the chemoresistance.
Unexpected diversity and novel lineages in the cosmopolitan genus Nanomia (Cnidaria: Siphonophorae: Physonectae)
Authors: Hosia Aino , Martell Luis , Mańko Maciej K. , Haddock Steven H. D. , Haberlin Damien , Mapstone Gillian M. 
Published: October 2024

Integrated use of molecular and morphological methods reveals unexpected diversity in the cosmopolitan siphonophore genus Nanomia. Species delimitation analyses based on COI and 16S sequences suggest up to three distinct lineages in addition to the previously accepted Nanomia bijuga (Delle Chiaje, 1844) and N. cara A. Agassiz, 1865. Here, we describe the North Pacific Nanomia septata sp. n., previously confused with both N. cara and N. bijuga, and provide improved morphological characters for the identification of these three Nanomia species. Phylogenetic analyses suggest two additional, hitherto undescribed clades from Japanese and Chinese waters, respectively, but the lack of morphological material prevents describing these putative species. The geographic distribution of molecularly and/or morphologically verified observations confirm a warm circumglobal distribution for N. bijuga and a boreal North Atlantic distribution for N. cara. Interestingly, four distinct lineages occur in the North Pacific, sometimes in close proximity. These contrasting patterns of distribution raise questions about pelagic speciation processes.Nanomia septata sp. n.: urn:lsid:zoobank.org:act:DAF15EA3-AFEA-4AE8-984F-BDFBCFE7E514urn:lsid:zoobank.org:pub:478049FC-F672-4D34-ABAE-CF4345EC64D7
Effect of mixed planting on soil nutrient availability and microbial diversity in the rhizosphere of Parashorea chinensis plantations
Authors: Li Wannian , Xie Le , Xu Yuanyuan , Yang Mei 
Published: October 2024

IntroductionParashorea chinensis Wang Hsie (Pc) is an endangered tree species endemic to tropical and subtropical China. However, the acidic red soil areas where it is distributed generally face nutrient limitation. The study of the effects of mixed planting on soil biogeochemical processes contributes to the sustainable management and conservation of Pc.MethodsWe selected pure and mixed stands of Pc and collected its rhizosphere and bulk soil samples to clarify the effect of mixed planting on the soil microbial community and the nutrient status.ResultsThe results showed that (1) All stands were strongly acidic phosphorus-deficient soils (pH &lt; 4.0, available phosphorus &lt;10.0 mg·kg−1). There was a significant rhizosphere aggregation effect for soil organic C, total and available N and K, microbial biomass, and inorganic P fraction. (2) The mixed planting significantly increased the soil water content, organic C, available nutrients, the activities of β-1,4-glucosidase and urease, and microbial biomass. The inorganic P fractions are more influenced by rhizosphere, while organic P fractions are more influenced by tree species composition. (3) Fungi and their ecological functions are more susceptible to tree species than bacteria are, and have higher community compositional complexity and α-diversity in mixed plantations. And mixed planting can improve network complexity among key microorganisms. (4) The correlation between soil microorganisms and environmental factors was significantly higher in mixed forests than in pure forests. Soil organic C, available N and P, microbial biomass C and N, β-1,4-glucosidase, and stable P fractions were the key environmental factors driving changes in fungal and bacterial communities.ConclusionIn conclusion, the mixed planting patterns are more advantageous than pure plantations in improving soil physicochemical properties, enhancing nutrient effectiveness, and promoting microbial activities and diversity, especially Pc mixed with Eucalyptus grandis × E. urophylla is more conducive to soil improvement and sustainable management, which provides practical references for relocation protection of endangered tree species and species selection and soil fertility management in mixed planting. In addition, the study highlighted the key role of rhizosphere microenvironment in soil nutrient cycling and microbial community structure, which provides new perspectives for a deeper understanding of soil-microbe-plant interaction mechanisms.
Pediatric pain physician workforce: an assessment of supply and demand
Authors: Theriault Christopher B. , Burns Tracy , Goldschneider Kenneth , Koka Anjali , Logan Deirdre , Weisman Steven J. , Wilder Robert T. , Windsor R. Blake , Zempsky William T. 
Published: October 2024

IntroductionMany youth with pain lack access to pediatric pain expertise. There is a critical shortage of pediatric pain physicians, due partly to a paucity of training programs in Pediatric Pain Medicine. Pain fellowships are Anesthesiology-based and there is no pathway to fellowship training or Pain Medicine board certification for pediatricians. This workforce assessment sought to examine the current state of Pediatric Pain Medicine in the United States and future interest in pursuing Pain Medicine among pediatricians.MethodsA multidisciplinary working group of Pain Medicine clinicians designed three surveys to examine pediatric comprehensive pain programs in the US, practice patterns of pediatricians and their motivations and opinions regarding Pain Medicine board certification, and current residents’ exposure to and interest in Pediatric Pain Medicine.ResultsWait times for initial evaluations are two months or longer for two-thirds of responding centers, and barriers to increase staff size and resources were reported, including an inadequate number of trained or available physicians. Pediatricians expressed interest in earning board certification in Pain Medicine, given the opportunity. Additionally, there is interest among pediatric residents in pursuing Pediatric Pain Medicine, and qualitative data highlight information residents perceived needing in order to pursue a career in the field.DiscussionResults demonstrate the need for increased training opportunities in pediatric pain medicine. A formal pathway to Pain Medicine for Pediatricians should be developed to increase the potential workforce and to address the lack of trained pediatric pain specialists, thereby improving access to care for youth with pain.
Navigating the path to equitable rheumatologic care for underserved children with quality improvement
Authors: Vora Sheetal S. , Mabus Sarah C. , Buitrago-Mogollon Talia L. 
Published: October 2024

ObjectiveThe aim of this quality improvement project is to identify children with rheumatologic conditions to prevent delayed or missed diagnosis in underserved pediatric populations. Our focus is on prompt and accurate identification and subsequent treatment of rheumatologic symptoms in pediatric patients referred from Atrium Health safety-net primary care clinics that deliver care to families without private insurance, including those lacking insurance entirely.MethodsWe collaborated with providers at one safety-net clinic to improve the processes of identification and subspecialty referral, resulting in an increase in the number of identified pediatric patients and referrals for these patients with potential rheumatologic disease. We used the Model for Improvement framework with rapid Plan–Do–Study–Act cycles and evaluated improvement with run and statistical process control charts.ResultsWe achieved improvement, with zero referrals in the previous 5 years for the targeted population increasing to 15 patient referrals within 1 year of project initiation. Despite this increase in referrals, the rheumatology clinic was able to see all priority patients within 20 business days from referral.ConclusionAn awareness of concerning rheumatologic symptoms in safety-net primary care clinics, combined with the use of both visual and decision aids, allows care teams to efficiently recognize and accurately refer patients needing specialty care.
Screening and expression validation of key proteins for secondary hair follicle growth in cashmere goats based on iTRAQ quantitative proteomics technology
Authors: Chang Jiale , Meng Fanhua , Zhang Ru , Feng Juan , Liu Yujing , Zhang Junjie , Liu Zhaomin , Liang Jiayue , Xiao Hongmei 
Published: October 2024

BackgroundThe growth of secondary hair follicles (SHFs) in cashmere goats has periodic changes, including telogen, anagen, and catagen, during which proteins play important roles as the executor of life activities.ResultsIn this study, the skin tissues of cashmere goats at three different growth stages of SHFs were collected for proteome sequencing and validation experiments. Through protein differential expression analysis and time series analysis, FKBP prolyl isomerase 10 (FKBP10) and fibrillin 2 (FBN2) were screened as the key proteins for SHF cycle growth of cashmere goats, and albumin (ALB), collagen type I alpha 1 chain (COL1A1) and elastin (ELN) were predicted to be their interacting proteins. The results of quantitative real-time PCR (qRT-PCR), western blot, and immunohistochemistry experiments showed that the mRNA and protein expression levels of FKBP10, FBN2, COL1A1, ELN and ALB were higher in anagen and lower in telogen. They were all highly expressed in the outer root sheath of SHFs in anagen.ConclusionFKBP10, FBN2, COL1A1, ELN, and ALB can promote the growth of SHFs in cashmere goats. This study lays the foundation for analyzing the growth cycle regulatory mechanism of SHFs in cashmere goats, and provides new ideas for further improving cashmere yield and quality.
Deficit Irrigation Regime Improves Phytosanitary Status of Cultivar Arbosana Grown in a Super High-Density Olive Orchard
Authors: Nicolì Francesco , Anaclerio Marco , Maldera Francesco , Nigro Franco , Camposeo Salvatore 
Published: October 2024

Super high-density (SHD) planting systems are very efficient in terms of production and water use. In these orchards, water-saving irrigation strategies are used precisely to keep the best sustainability compared to traditional orchards. With agro-climatic and eco-physiological parameter monitoring, the SHD planting system has become even more efficient. SHD orchards, however, could also be more so affected by other pests and diseases than traditional systems, but field responses are still unknown when olive trees are grown in SHD groves. The goal of this two-year field research was to investigate the seasonal changes of the phytosanitary status of ‘Arbosana’ grown in an SHD orchard under both regulated deficit (RDI) and full irrigation regimes (FI). This study investigated the influence of the two different irrigation regimes on the infections of three olive tree key diseases: cercosporiosis (Pseudocercospora cladosporioides), cycloconium (Fusicladium oleagineum), and olive knot (Pseudomonas savastanoi pv. savastanoi). RDI significantly reduced the severity of cercosporiosis in 2020 compared to FI but not in 2021. Cycloconium was observed only as a latent infection during the two studied years and olive knot was not influenced by irrigation but only by weather conditions. These findings suggest that irrigation management can play a key role in controlling cercosporiosis effectively in SHD olive orchards, but also that weather conditions have an even higher impact on the tree key diseases.
Проблема формирования солидарности в экономике солидарности
Authors: Столетов А.И. , Лукманова Р.Х. 
Published: October 2024

Экономика солидарности как реакция на кризис глобальных форм экономического капитализма ставит проблему природы своей солидарности. Социально-философский анализ с применением системно-структурного подхода позволил раскрыть существенные особенности этой солидарности: она возникает в сообществах социального порядка открытого типа с малой дистанцией власти и открытыми элитами; предполагает приоритет неформальных институциональных структур перед формальными, связана с доверием к другим членам сообщества и заботой о нуждающихся в помощи; имеет рефлексивный характер и сетевую структуру; требует правильно настроенной системы высшего образования с акцентом на креативности интенсивного типа, направленной на этические и смысловые аспекты субъекта.
The concept of economic solidarity, as a response to the global forms of economic capitalism, raises the question of the nature of the solidarity it espouses. A sociological and philosophical analysis employing a systemic and structural approach has revealed the essential characteristics of this solidarity. Such forms of solidarity emerge within open-type social orders where authority is distributed widely and elites are accessible. This indicates that informal institutional structures have precedence over formal ones. This is contingent upon a sense of trust in other members of the community and a willingness to provide assistance to those in need. It is a reflexive and networked phenomenon. A properly configured system of higher education is required, with an emphasis on intensive creativity type, which focuses on the ethical and conceptual aspects of the individual.
ДРЕВНИЙ РИМ И АНТИЧНАЯ ЭКОНОМИЧЕСКАЯ СИСТЕМА, ФИНАНСОВЫЕ ИНСТИТУТЫ И ИХ ВЛИЯНИЕ НА ГОСУДАРСТВЕННОЕ УСТРОЙСТВО
Authors: ПАВЛОВ О.В. 
Published: October 2024

В данном тексте рассматривается вопрос экономического устройства общественных отношений с древности до настоящего времени. Автор указывает на значение письменных источников древних цивилизаций, таких как Законы Ману, Трактаты Гуань-цзы, и Законы Хаммурапи, в которых отражены нормы рабовладельческого строя и роль государства в защите собственности. Упоминается также экономическая система древности, с натуральным производством и появлением понятия экономики, представленного Ксенофонтом. Важным моментом является обсуждение понятий богатства и удовлетворения потребностей через экономику и хрематистику по Аристотелю. Также поднимается тема финансовых и банковских операций в Древнем Риме через обменные конторы и финансистов, описание процентов по кредитам и контроля над экономической деятельностью. Значительное внимание уделено религиозным храмам, соперничающим с древними банковскими образованиями. Анализ трансформации государства, социокультурных факторов и взаимодействия с другими странами подчеркивает важность гуманистического развития и сотрудничества. Таким образом, аннотация выделяет ключевые моменты развития экономических отношений на протяжении истории и значение их в контексте социальных и культурных изменений.
This text examines the issue of the economic structure of public relations from antiquity to the present. The author points out the importance of written sources of ancient civilizations, such as the Laws of Manu, the Treatises of Guan Tzu, and the Laws of Hammurabi, which reflect the norms of the slave system and the role of the state in protecting property. The economic system of antiquity is also mentioned, with natural production and the emergence of the concept of economics, presented by Xenophon. An important point is the discussion of the concepts of wealth and satisfaction of needs through economics and chrematistics according to Aristotle. The topic of financial and banking transactions in Ancient Rome through exchange offices and financiers, the description of interest on loans and control over economic activity is also raised. Considerable attention is paid to religious temples competing with ancient banking institutions. The analysis of the transformation of the state, socio-cultural factors and interaction with other countries emphasizes the importance of humanistic development and cooperation. Thus, the abstract highlights the key points of the development of economic relations throughout history and their significance in the context of social and cultural changes.
ДОХОДЫ НАСЕЛЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ: АНАЛИЗ ДИНАМИКИ И СТРУКТУРЫ
Authors: РОМАНОВА Т.В. , РОМАНОВ Р.В. 
Published: October 2024

В данной статье рассмотрено современное состояние доходов населения Российской Федерации. Проанализированы основные стоимостные показатели уровня жизни населения Российской Федерации и выстроена динамика формирования денежных доходов россиян в период до пандемии и в настоящее время и проанализирована динамика размеров прожиточного минимума и минимального размера оплаты труда в России. Исследование проводилось за период 2019-2023гг. на основе данных Федеральной службы государственной статистики.
This article examines the current state of income of the population of the Russian Federation. The main cost indicators of the standard of living of the population of the Russian Federation are analyzed and the dynamics of the formation of monetary incomes of Russians in the period before the pandemic and at the present time are built and the dynamics of the size of the subsistence minimum and minimum wage in Russia are analyzed. The study was conducted for the period 2019-2023 based on data from the Federal State Statistics Service.