bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treated Versus Untreated Mental Health Problems in Adolescents: A Six-year Comparison of Emotional and Behavioral Problem Trajectories
Authors: Jörg F. , Raven D. , Visser E. , Schoevers R. , Oldehinkel T. 
Published: June 2017

IntroductionMultidisciplinary guidelines in adolescent mental health care are based on RCTs, while treatment efficacy can be different from effectiveness seen in ‘the real world’. Studies in the real world conducted so far suggest that treatment has a negligible effect on follow-up symptomatology. However, these studies did not incorporate the pre-treatment trajectory of symptoms nor investigated a dose-response relationship.ObjectivesTo test whether future treatment users and non-users differed in emotional and behavioural problem scores, whether specialist mental health treatment (SMHT) was effective in reducing problem levels while controlling for pre-treatment trajectory, and to seek evidence of a dose-response relationship.MethodsSix-year follow up data were used from the Tracking Adolescents’ Individual Lives Survey (TRAILS). We identified adolescents with a clinical level of problem behaviour on the Child Behaviour Checklist or Youth Self Report and first SMHT between the ages 13 and 16. Adolescents with a clinical level of problem behaviour but without SMHT use served as control group. A psychiatric case register provided data on number of treatment contacts. Using regression analysis, we predicted the effect of treatment on post-treatment problem scores.ResultsTreated adolescents more often had a (severe) diagnosis than untreated adolescents. Pre-treatment trajectories barely differed between treated and untreated adolescents. Treatment predicted an increase in follow-up problem scores, regardless of the number of sessions.ConclusionThe quasi-experimental design calls for modest conclusions. We might however need to take a closer look at real-world service delivery, and invest in developing treatments that can achieve sustainable benefits.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Ecological Momentary Assessment of Bipolar Disorder Episodes with a Smartphone Application: Study Protocol
Authors: Blom M. , Karilampi U. , Carlsen H.K. , Ioannou M. , Sörhag M. , Steingrimsson S. 
Published: June 2017

IntroductionSubclinical symptoms of depression or mania, present prior to clinical manic or depressive episodes in individuals with bipolar disease. Mobile applications that measure habitual behavioral patterns such as mobility, physical activity level and social engagement present an opportunity to identify state transitions preceding relapse. This could lead to earlier intervention and improved treatment outcome.AimsTo identify associations between changes in habitual behavioral patterns measured with smartphone usage and psychiatric emergency room visits or admissions for bipolar patients.MethodsIn a case-crossover study, around 70 patients at a specialized outpatient clinic for bipolar disorder will be offered to install MoodMapper®, an application that registers text message and calls (but not communication content or recipients), mobility (but not location), number of steps taken, screen-time, and battery level. A baseline level for each individual will be established. Deviations from baseline habitual behavioral patterns in the time preceding a psychiatric emergency room visits or admissions will be analyzed in order to establish predictor variables. The patients will be followed up to 18 months.ResultsPreliminary results will be presented.DiscussionSmartphone-collected behavioral data can be used to predict worsening or improvement of a patient's condition. As smartphone ownership becomes more commonplace, mobile apps present a unique opportunity to detect digital real-time signatures of mental illness in a way that is minimally invasive to individual's daily life and privacy.
Mental Health Problems Among Male Offenders and Youths with Conduct Problems
Authors: Halilaj G. , Fanaj N. , Drevinja F. 
Published: June 2017

BackgroundMental health problems among youth, are frequent especially in offenders and as such is very important to identify as early as possible.ObjectivesTo estimate and compare level of some mental health problems between three groups of male youths: juvenile offenders in correctional center, adolescents with conduct problems and university students.MethodIt is cross-sectional quantitative study. The sample consisted of three male groups: 41offenders placed in one correctional center (Mean age = 18.02; SD = 2.20); 41 male students of secondary school with conduct problems (Mean age = 16.97; SD = 61) and 42 male university students randomly selected (Mean age = 19.7; SD = 1.77). They filled questionnaire MAYSI–2. Data processing was done with SPSS 21.0 and Microsoft Excel 2013.ResultsJuvenile offenders in correctional center scored significantly higher than other two groups of youth in alcohol/substance abuse subscale (P = 001), Suicidal ideation subscale (P = 048) and traumatic stress subscale (P = 003) based on Kruskal-Wallis Test. Juvenile offenders in correctional center scored higher but non-significantly in angry/irritable and depression/anxious subscales. Students of secondary school with conduct problems scored higher but non-significantly in thought disturbance and somatic subscales.ConclusionMale juvenile offenders have significantly more mental health difficulties. Mental health needs of youths in Kosovo (especially juvenile offenders) seem to be numerous and is important to be addressed properly.
Causes of Institutionalization of Children and Adolescents in a Shelter in Brazil
Authors: Guilherme E. , Dos Santos S.D. 
Published: June 2017

IntroductionA growing number of studies investigating the relationship between violence and problems in child psychiatry. Consistent findings have been verified in studies related to aggressive behavior, antisocial and post-traumatic stress disorder with the violence against children. The financial costs associated with child abuse and neglect, including future lost earnings and expenses with mental health treatments were estimated at $ 94 billion US in 2010. The abuse and child neglect can cause permanent changes in the body's response to stress, with profound changes in the brain development.MethodsConsisted of an exploratory study of character quantitative and qualitative, with document design. Records of children and adolescents who stayed in the shelter from 2011 to 2015 were surveyed. In order to collect data was used input and shutdown records used for shelter.ConclusionsUnlike Brazil and the rest of the world's data, the leading cause of institutionalization in this work in the town of Mafra, was neglect rather than abuse. Perhaps for the under-reporting of abuse cases. This, coupled with the fact that there are no typically physical findings associated with sexual abuse, made the detection more difficult. This paper alerts the importance to increase our ability to identify all child abuse experiences, for protecting our children. Not only sexual abuse, but also physical abuse could benefit from strategies to enhance detection.
Pathways to Care and Patterns of Care in First Episode Psychosis Patients Treated in Community Based-mental Health Services. A 5-Years Follow-up from the PICOS
Authors: Miglietta E. , Lasalvia A. , Comacchio C. , Cristofalo D. , Bonetto C. , Tosato S. , De Santi K. , Zanatta G. , Petterlini S. , Zoppei S. , Dimitri G. , Cremonese C. , Ramon L. , Ruggeri M. 
Published: June 2017

IntroductionInternational treatment guidelines recommend that key elements to reduce the burden of psychosis are the early identification of people and the adoption of specific evidence based interventions.ObjectivesTo investigate the pathway to care and patterns of interventions provided by community based-mental health services (CMHS) to a cohort of first-episode psychosis (FEP) patients over 5-years period, exploring in which degree guidelines are met in routine clinical practice.MethodsStudy conducted in the context of the Psychosis Incident Cohort Outcome Study (PICOS), a multisite naturalistic research conducted in the Veneto Region (Italy) on FEP patients in a 4.6 million inhabitants catchment area. A comprehensive set of standardized measures was used, including ad hoc schedules to collect information on referrals to psychiatric services and on pharmacological and psycho-social treatments according to a multiwave follow-up design (1-, 2- and 5 years).ResultsThree hundred and ninety-seven FEP patients were assessed at BL, 286 at 1 year, 233 at 2 years and 205 at 5 years. 47.4% of patients were helped to seek care by a relative and more than one half entered the treatment route through an emergency access. Regarding the interventions received, 96% of patients had been prescribed neuroleptics and atypical were the most prescribed class (66.9%). Only half received a psychosocial intervention during the first year and this percentage progressively decreased at each FU.DiscussionFindings highlight discrepancies between interventions provided by CMHS and the best treatment options recommended by guidelines, suggesting the need to implement specific initiatives aiming to close the gap between research and clinical practice.
The Relation Between Socio-environmental Factors and Intellectual Disability: Unraveling the Knot
Authors: Rondini E. , Bertelli M. , Scuticchio D. 
Published: June 2017

Background and aimThe current literature indicates that people with intellectual disabilities (ID) present quantitative and qualitative peculiarities of various socio-environmental factors than the general population. Although the identification of such peculiarities would have very important implications for the development of preventive, rehabilitative and inclusive procedures, valuable data are still lacking. The aim of the present paper was to assess the significance of the relationship between socio-environmental variables in person with ID, with particular reference to individual history and life contexts.MethodsA consecutively recruited sample of 112 participants with ID attending residential or clinic/rehabilitative services across Italy was evaluated by the administration of ISTORIA (Historiographical organized interview for adult intellectual retard), a semi-structured questionnaire designed to investigate clinical and personal history of the person. A considerable percentage of the samples have co-occurent psychiatric disorder. Scores obtained were statistically processed through frequency analysis and calculation of correlation indexes.ResultsSignificant correlations were found between the family, the educational/professional environments, and the inclusion in society. Further associations concerned social relationships within and outside the family, the changes of living accommodation, and the level of environmental stimulation received.ConclusionsBoth findings from previous research and the ones of this work confirm the importance of investigating the mechanisms involved in the acquisition of social skills by persons with ID, through family dynamics and participation in community life, as protective factor against the worsening of disabilities and potentially of psychopathological vulnerability that affects this population.
Insight Gained from Genome-wide Interaction and Enrichment Analysis on Weight Gain During Citalopram Treatment
Authors: Corfitsen H. , Drago A. 
Published: June 2017

IntroductionWeight gain is a side effect of pharmacological antidepressant treatments, causing a poorer compliance, increasing the risk of metabolic syndrome and periods of untreated disease.ObjectivesThe ability to precisely prescribe pharmacological treatments based on personal genetic makeups would increase the quality of the current antidepressant treatments.AimsThe molecular pathways enriched during citalopram induced weight gain are identified.Methods643 depressed citalopram treated individuals with available clinical and genome-wide genetic information were investigated in the present contribution in order to identify the molecular pathways that holds the key to weight gain. Statistics were conducted in R environment (Bioconductor and Reactome packages), ANOVA and MANCOVA served when appropriate. Plink was used for genetic analysis in a linux environment.ResultsOne hundred and eleven individuals had their weight increased after treatment with citalopram. The axon guidance (P. adjust = 0.005) and the developmental biology pathway (P. adjust = 0.01) were found to be enriched in genetic variations associated with weight gain.ConclusionsThe development biology pathway includes molecular cascades involved in the regulation of beta-cell development, and the transcriptional regulation of white adipocyte differentiation. A number of variations were harboured by genes whose products are involved in the synthesis of collagen (COL4A3, COL5A1 and ITGA1), activity of the thyroid-hormones (NCOR1 and NCOR2), energy metabolism (ADIPOQ, PPARGC1A) and myogenic differentiation (CDON). A molecular pathway analysis conducted in a sample of depressed patients identifies new candidate genes whose future investigation may grant relevant insights in the molecular events that drive weight gain during antidepressant treatment.
Cognitive Dysfunctions in the Psychoses and their Impact on Patients’ Social Functioning
Authors: Mucci A. , Galderisi S. 
Published: June 2017

IntroductionImpairment of neurocognitive functions, such as attention, memory or executive functions, as well as of social cognition, particularly of affect recognition and theory of mind, are frequently observed in people with Schizophrenia or other psychotic disorders. These dysfunctions are associated with poor real-life functioning. Social cognition deficits mediate in part the impact of neurocognitive dysfunction on functional outcome.AimsTo review literature findings on prevalence, severity and association with functional outcome of neurocognitive and social cognitive deficits in schizophrenia and other psychotic disorders.MethodsWe searched PubMed for English/Italian or French full-text publications with the keywords.schizophr*/psychosis/psychot*/AND neurocognitive/cognitive/neuropsychological/memory/attention/”executive function”/learning/”social cognition”/”theory of mind”/”affect recognition”/”acial emotion recognition”/”emotional intelligence”/”emot* recognition”. Furthermore, we manually searched the reference lists of relevant papers, systematic reviews and meta-analyses.ResultsIn people with schizophrenia, schizoaffective disorder or bipolar disorder with psychotic features, neurocognitive and social cognition deficits were observed in all phases of the disorders, even after symptom remission. Some of these deficits were observed in subjects at high-risk to develop schizophrenia before psychotic onset. In all these subjects, cognitive deficits are associated with worse psychosocial functioning and poor quality of life. Pharmacological treatments do not alleviate cognitive deficits, which can also limit the benefit of other psychological or psychosocial interventions.ConclusionsNeurocognitive and social cognition deficits need to be targeted by specific interventions to improve real-life functioning and quality of life of people with schizophrenia or psychotic disorders.Disclosure of interestAM received honoraria or advisory board/consulting fees from the following companies: Janssen Pharmaceuticals, Otsuka, Pfizer and Pierre Fabre.SG received honoraria or advisory board/consulting fees from the following companies: Lundbeck, Janssen Pharmaceuticals, Hoffman-La Roche, Angelini-Acraf, Otsuka, Pierre Fabre and Gedeon-Richter.
Electrodermal Reactivity and Suicide
Authors: Sarchiapone M. 
Published: June 2017

Electrodermal Activity (EDA) refers to changes in electrical conductance of the skin. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high negative predictive value for suicide. The aim of the present study is to test the effectiveness and the usefulness of the EDOR® (ElectroDermal Orienting Reactivity) Test as a support in the suicide risk assessment of depressed patients.One thousand five hundred and seventy three patients with a primary diagnosis of depression, whether currently depressed or in remission, have been recruited at 15 centres in 9 different European countries. Depressive symptomatology was evaluated through the Montgomery-Asberg Depression Scale. Previous suicide attempts were registered and the suicide intent of the worst attempt was rated according to the first eight items of the Beck Suicide Intent Scale. The suicide risk was also assessed. During the EDOR® Test two fingers are put on gold electrodes and a moderately strong tone is presented through headphones now and then during the test. The EDOR® Test is able to register the electrodermal responses to those tones, along with the blood volume in the fingers. Each patient is followed up for one year in order to assess the occurrence of suicidal behaviors.Expected results would be that patients realizing a suicide attempt with a strong intent or committing suicide should be electrodermally hyporeactive in most cases and non-hyporeactive patients should show only few indications of death intent or suicides. Preliminary findings will be presented.Disclosure of interestThe participating centres received funding for this study by EMOTRA AB, Sweden.
Predictors of satisfaction with life among older adults
Authors: Von Humboldt S. , Leal I. 
Published: June 2017

IntroductionIncreasing longevity brings challenges for older adults’ satisfaction with life (SWL).AimsThis study aims at exploring a structural model of predictors of SWL in a cross-national sample of older adults.MethodsA community-dwelling sample of 1234 older adults was assessed regarding SWL, sense of coherence (SOC) and socio-demographic, lifestyle and health-related characteristics. Structural equation modeling was used to investigate a structural model of the self-reported SWL, comprising SOC, socio-demographic characteristics (age, sex, education, marital and professional status, household, adult children, income, living setting and religion), lifestyle and health-related characteristics (physical activity, recent disease and medication).ResultsSignificant predictors are SOC (β = .733; P < .001), religion (β = .725; P < .001), income (β = .551; P < .001), adult children (β = .546; P < .001), education (β = –.403; P < .001), living setting (β = –.292; P < .001) and medication (β = –.197; P < .001). The variables accounted for 24.8% of the variability of SWL. Moreover, differences between the four nationality groups (F(3, 671) = 3.671, P = .066) were not found concerning SWL.ConclusionsSense of coherence is the strongest predictor of self-reported SWL. Other predictors are religion, income, adult children, education, living setting and medication. The four nationalities did not present significant differences, concerning SWL. This study highlights the factors that influence older adults’ SWL, namely, SOC, religion and income, as promoters of aging well, within a salutogenic model of health for older populations.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Formal thought disorder in schizophrenia and bipolar disorder: A systematic review and meta-analysis
Authors: Alptekin K. , Yalincetin B. , Bora E. , Berna A. 
Published: June 2017

Historically, formal thought disorder has been considered as one of the distinctive symptoms of schizophrenia. However, research in last few decades suggested that there is a considerable clinical and neurobiological overlap between schizophrenia and bipolar disorder (BP). We conducted a meta-analysis of studies comparing positive (PTD) and negative formal thought disorder (NTD) in schizophrenia and BP. We included 19 studies comparing 715 schizophrenia and 474 BP patients. In the acute inpatient samples, there was no significant difference in the severity of PTD (d = –0.07, CI = –0.22–0.09) between schizophrenia and BP. In stable patients, schizophrenia was associated with increased PTD compared to BP (d = 1.02, CI = 0.35–1.70). NTD was significantly more severe (d = 0.80, CI = 0.52–0.1.08) in schizophrenia compared to BP. Our findings suggest that PTD is a shared feature of both schizophrenia and BP but persistent PTD or NTD can distinguish subgroups of schizophrenia from BP and schizophrenia patients with better clinical outcomes.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Effect of Clozapine on Psychiatric Comorbidities in Patients with Schizophrenia
Authors: Gürcan G. , Hun Şenol Ş. , Anıl Yağcıoğlu A.E. , Ertuğrul A. 
Published: June 2017

IntroductionClozapine has superior efficacy in treatment-resistant schizophrenia, and has various effects on psychiatric comorbidities, which may affect the illness course.AimsWe aimed to assess the past and current psychiatric comorbidities in schizophrenia patients treated with clozapine, and study their relationship with clinical variables.MethodsConsecutive 122 outpatients who met DSM-IV criteria for schizophrenia receiving clozapine were included. Information about past and current clinical status were gathered through a clinical interview and review of the medical records, along with laboratory test results. Patients were assessed with structured clinical interview for Axis-I Disorders for DSM-IV, Clinical Global Impression Scale, Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Panic and Agoraphobia Scale (PAS), WHO-Disability Assessment Schedule-II.ResultsThere was a significant decrease in the diagnosis of depression, alcohol and substance use disorder, number of suicide attempts, and an increase in the diagnosis of obsessive compulsive disorder (OCD) after clozapine initiation. Clozapine related de novo OCD appeared in 48.4% of the patients, and there was a positive correlation between Y-BOCS total scores and clozapine dose and plasma levels. In the de novo OCD group, compulsion scores were higher than obsession scores with checking most prevalent among compulsions. Total PANSS, Y-BOCS, PASscores were positively correlated withtotal disability score.ConclusionsClozapine seems to decrease comorbid depression, alcohol and substance use and number of suicide attempts and increase OCD. Assessment and treatment of psychiatric comorbidities in clozapine using schizophrenia patients is vital to decrease disability.Disclosure of interestThe authors have not supplied their declaration of competing interest.