bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of the Modified Broström Procedure Augmented With Suture-Tape for Ankle Instability in Patients With Generalized Ligamentous Laxity
Authors: Cho Byung-Ki , Park Kyoung-Jin , Park Ji-Kang , SooHoo Nelson F. 
Published: April 2017

Background: Although recent biomechanical studies have reported mechanical superiority of augmented anterior talofibular ligament reconstruction using suture-tape, clinical evidence regarding the efficacy of suture-tape augmentation is still insufficient. This prospective study was performed to evaluate the outcomes of the modified Broström procedure augmented with suture-tape for chronic ankle instability with generalized ligamentous laxity, which has been known to be a poor prognostic factor for anatomic ligament repair. Methods: Twenty-eight patients with generalized ligamentous laxity were followed for more than 2 years after the augmented modified Broström procedures for chronic ankle instability. Generalized ligamentous laxity was defined as a Beighton score ≥4 points. The clinical evaluation consisted of the Foot and Ankle Outcome Score (FAOS) and Foot and Ankle Ability Measure (FAAM) score. Measurement of talar tilt angle and anterior talar translation was obtained from stress radiographs to evaluate mechanical ankle stability. Results: FAOS and FAAM scores had significantly improved from preoperative average 63.2 and 54.3 points to 90.6 and 89.5 points at final follow-up, respectively ( P < .001). Talar tilt angle and anterior talar translation had significantly improved from preoperative average 16.2° and 12.1 mm to 3.6° and 4.2 mm at final follow-up, respectively ( P < .001). Preoperative side-to-side comparison with stress radiographs was significantly different, but this returned to within nonstatistical differences at final follow-up, respectively ( P = .105, .532). Although 6 patients sustained an ankle sprain after operation, only 1 patient (3.6%) showed a recurrence of subjective and mechanical instability. Conclusions: Suture-tape augmentation for the modified Broström procedure appears to be an effective operative alternative for chronic ankle instability with generalized ligamentous laxity. As one of the methods to improve the clinical outcomes in patients with relative contraindications of the modified Broström repair, this procedure provided reliable stability with the advantages of anatomic ligament repair through the augmentation using suture-tape. Level of Evidence: Level IV, prospective case series.
Pro-tumoural CXCL10/CXCR3-A autocrine loop in invasive mucinous lung adenocarcinoma
Authors: Duruisseaux Micha�l , Rabbe Nathalie , Antoine Martine , Vieira Thibault , Poulot Virginie , Cadranel Jacques , Wislez Marie 
Published: April 2017

Invasive mucinous adenocarcinoma (IMA) is a mucinous variant of lepidic predominant lung adenocarcinoma (LPA) and associated with a worse prognosis. We postulated that cytokine expression would enable us to differentiate IMA from LPA in terms of prognosis and acquisition of pro-tumoural capacities.
A 30-cytokine panel was assessed in bronchoalveolar lavage fluids (BALF) from IMA (n=38), LPA (n=25) and control samples (n=7). We investigated the expression of differentially expressed cytokines and splice variants of their receptors in surgical samples. The presence of
EGFR
and
KRAS
mutations were determined. We also examined the expression of cytokines and splice variants of their receptors in different cell lines, exploring their functional impact on signalling pathways, proliferation and migration.
Only C-X-C motif chemokine 10 (CXCL10) was differentially expressed, namely overexpressed in IMA BALF compared with LPA. CXCL10 overexpression in BALF was linked to a worse prognosis. In surgical samples, CXCL10 and its receptor C-X-C motif chemokine receptor 3 (CXCR3) were overexpressed in IMA compared to LPA. A pro-tumoural CXCR3-A splice variant was overexpressed in IMA, suggesting a CXCL10/CXCR3-A autocrine loop in IMA. CXCL10 and CXCR3 expression were not correlated with
EGFR
or
KRAS
status. CXCL10 up-regulated CXCR3-A expression, Erk1/2 phosphorylation and enhanced migration in the mucinous H2228 cell line.
CXCL10/CXCR3-A may play a pro-tumoural role in IMA
via
an autocrine mechanism.
Conditional Survival: An Assessment of the Prognosis of Patients at Time Points After Initial Diagnosis and Treatment of Locoregional Melanoma Metastasis
Authors: Haydu Lauren E. , Scolyer Richard A. , Lo Serigne , Quinn Michael J. , Saw Robyn P.M. , Shannon Kerwin F. , Spillane Andrew J. , Stretch Jonathan R. , McCarthy William H. , Thompson John F. 
Published: April 2017

PurposeStandard cancer staging and prognostic estimates are determined at the time of the patient’s initial disease presentation. Conditional survival is an alternative, dynamic assessment from follow-up time points after the initial disease diagnosis and is based on the condition of survivorship. Estimates of conditional survival can provide critical prognostic information for patients and clinicians, guide subsequent cancer follow-up schedules, and influence decisions regarding treatments. The current study presents conditional survival estimates developed from a cohort of 4,540 patients diagnosed with stage III melanoma treated at a single institution.MethodsPatients with stage III disease at first melanoma diagnosis (initial; n = 2,042), or who developed locoregional metastasis as a first recurrence some time after primary diagnosis (recurrent; n = 2,498), were assessed. Conditional melanoma-specific survival (MSS) estimates up to 5 years after diagnosis were adjusted for age, sex, and 8th edition American Joint Committee on Cancer (AJCC) stage.ResultsOlder age at diagnosis of stage III disease conveyed a worse prognosis at each conditional survival time point. Males had significantly worse MSS outcomes for up to 2 years of conditional survival, after which males and females had similar MSS. For patients with AJCC stage IIIB and stage IIIC disease, MSS outcomes were similar to those of patients with stage IIIA disease after 3 and 5 years of survivorship, respectively.ConclusionAdjuvant systemic treatments may have the greatest benefit when administered within the first 2 years of stage III melanoma diagnosis, during which period prognosis is significantly worse for male patients of increasing age and AJCC substage. Conditional survival estimates illustrate improved survival prospects for patients with cancer returning for follow-up and may define a finite period of increased risk after diagnosis.
Standardized symptom screening: Cancer Care Ontario's expanded prostate cancer index composite for clinical practice (EPIC-CP) provincial implementation approach.
Authors: Haji Farzana , Barbera Lisa Catherine , Bedford Colleen , Nichols Brett , Brundage Michael Donald 
Published: April 2017

100 Background: Cancer Care Ontario endorses patient reported outcome measures to improve outcomes and experience for nearly 14 million Ontarians. The EPIC-CP tool, validated to screen/monitor symptoms and side-effects in men with localized prostate cancer, was selected to improve patient and provider experience, and facilitate symptom management. Two pilots tested EPIC-CPs feasibility and acceptability. Subsequent recommendations include: province-wide implementation, improving technological privacy, patient and provider education and communication processes. This abstract will describe the provincial strategy for implementation of EPIC-CP. Methods: The implementation approach involved stakeholder-driven practices based on Kotter’s organizational process framework. Clinical, technical, administrative and patient stakeholder representatives from 14 cancer centres formed working groups to create a climate for change, to engage centres to strategize locally, to implement and sustain change and to address the challenges identified by the EPIC-CP pilot. Results: The final pilot ended in June 2015, and executive endorsement for EPIC-CP provincial implementation in March 2016. A schedule for multi-site phased implementation was informed by stakeholder consultations and began in Oct 2016. Technological privacy improvements were informed by 95 representatives creating a multidisciplinary team tasked with provincial oversight, development of EMR guidelines and IT solutions. Five patient and five clinical educational guides were designed to assist in symptom management, each focusing on one domain of EPIC-CP. Creation of the guides drew on the clinical and scientific expertise among 12 clinicians of varying disciplines in collaboration with four patients. This team assisted in enhancing communication processes by designing 21 training materials, including FAQs and narrated guides, accessible on a central communications hub. Conclusions: Results indicate that this framework-based, stakeholder-driven approach was successful and could be applied to other wide-scale implementations of symptom management tools.
Sensitivity and specificity of self-reported cancer history compared to cancer registry.
Authors: Earle Craig 
Published: April 2017

234 Background: The Ontario Health Study (OHS) is a large prospective epidemiologic cohort study in which any Ontario resident eighteen years of older may enroll regardless of prior medical history. Baseline data are collected using web-based tools. As part of the consent process, participants are asked for consent to link study data with administrative and health care claims databases, including the Ontario Cancer Registry (OCR). There is an option to enter their Health Insurance Number (HIN) for this purpose. The purpose of this study was to link these data and evaluate the accuracy of self-reported cancer history compared to the cancer registry. Methods: Consenting participants that provided HINs were deterministically linked to the administrative data. Those that did not were probabilistically linked using name, sex and date of birth. Cancer registry records indicating a cancer diagnosed before the date of completion of the OHS baseline survey were considered the gold standard. Concordance, sensitivity, and specificity were assessed. Results: OHS records were successfully linked to administrative claims data and the Ontario Cancer Registry (OCR) with an 85.13% match rate. The final cohort consisted of 139,798 participants. A personal history of cancer was reported by 13,171 of these subjects, out of which 10,066 were found with a record in the OCR. The sensitivity of self-report was 77% and the specificity 95%. Excluding cancers diagnosed after the completion of the baseline survey increased sensitivity of self-report to 93%. The main area of discrepancy causing low sensitivity was the self-reporting of non-melanomatous skin cancers in the OHS questionnaire. Conclusions: While some self-over-reporting of cancer history may occur, cancers with lower metastatic potential tend to be under-captured in our provincial cancer registry. These findings have implications for cohort creation for research and quality improvement.
A consolidated screening tool for supportive oncology needs and distress.
Authors: Weldon Christine B. , Vance Nancy , Scheu Amy , Wiebe Lauren Allison , Lo Shelly S. , Deamant Catherine , Roggenkamp Betty , Patel Urjeet , Khosla Paramjeet , Robinson Patricia A. , Penedo Frank J. , Gerhart James , Lillis Teresa , Dale William , Gordon Ana , Knightly Eileen , Berardi Rosa , Trosman Julia Rachel 
Published: April 2017

47 Background: The IOM 2013 Report recommends that supportive oncology care start at cancer diagnosis; the Commission on Cancer (CoC) Standard 3.2 requires distress screening and indicated action. Screening tools are not standardized across institutions and often address only a portion of patients’ supportive oncology needs. Methods: A collaborative of 100+ clinicians, funded by The Coleman Foundation, developed a patient-centric consolidated screening tool based on validated instruments (NCCN Distress, PHQ-4, PROMIS) and IOM and CoC. The screening tool was piloted at 6 practice-improvement cancer centers in the Chicago area (3 academic, 2 safety-net, 1 public). Patients, providers assessing patients’ screening results (assessors), and providers receiving referrals (providers) were surveyed after use of the screening tool. Descriptive statistics were used to assess effectiveness of the tool. Results: Responders included 175 patients, 81 assessors, and 26 referral providers (social workers, chaplains, subspecialists). The majority of patients (160/175, 91%) completed the screening in <10 minutes, across all patients the screening tool averaged 4 ½ minutes. Most assessors (59/77, 76%) spent <5 minutes reviewing screening results. Most patients, assessors, and providers reported the screening tool asked the “right questions”. Assessors reporting partial relevance of some screening questions for 34% (26/77) of patients, uncovered ≥ 1 relevant needs for 96% (25/26) of those patients (p = 0.002). Conclusions: Use of a consolidated supportive oncology screening tool across multiple institutions is feasible, identified unmet patient needs, and was beneficial for assessors and providers. As the tool is adopted by collaborating institutions, variability in supportive oncology screening practices may decline, thus improving patient care. The tool has implications for quality improvements and national dissemination. [Table: see text]
Bone marrow aspirate quality assessment.
Authors: Safyan Rachael A. , Mathew Matthen , Marchi Enrica , Accordino Melissa Kate 
Published: April 2017

76 Background: Bone marrow evaluation is the cornerstone of diagnosis, staging, and measurement of treatment response for many hematologic diseases. Aspirate adequacy is defined by whether the procedure results in a specimen of sufficient quality for pathologic review. Between July 1, 2014 and June 30, 2015, 49.3% of inpatient bone marrow aspirates performed by Hematology/Oncology fellows at Columbia University Medical Center were classified as suboptimal. Methods: We used the Plan-Do-Study-Act methodology to 1) understand the factors contributing to suboptimal aspirates, 2) evaluate the scope of the problem at both fellowship and institutional levels, 3) develop a training seminar to educate fellows on the procedure techniques, and 4) monitor for improvement post-intervention. We identified inpatient bone marrow biopsies performed by Hematology/Oncology fellows between July 1, 2015 and June 30, 2016 and tabulated aspirate adequacy as noted in the reports. A faculty-led educational seminar was held on February 1, 2016. Fellows completed a pre- and post-intervention survey to assess knowledge and experience with bone marrow aspirates. Bone marrow biopsy billing data was used as a surrogate marker for attending supervision. Results: All Hematology/Oncology fellows (n = 19) at Columbia University Medical Center participated. The pre-intervention survey (18 responses; 94.7%) revealed 76.5% of fellows had formal bone marrow aspirate training, 66.6% had supervision 25% to 75% of the time, and 52.9% were uncomfortable performing the procedure alone. Of the 43 aspirates from the pre-intervention period, 22 (51.2%) were adequate. 94.7% of fellows attended the training seminar. Post-intervention, 27 of 50 (54%) bone marrow aspirates were adequate. The post-intervention survey (16 responses; 84.2%) showed 93.3% of fellows were confident performing the procedure alone. There were fewer procedures billed in the post-intervention period (20.9% pre vs 8% post). Conclusions: A formal educational seminar on bone marrow aspirate technique increased fellow comfort with the procedure and trended toward improved aspirate adequacy. The next study phase will institute an annual training session for incoming fellows and create a bone marrow specimen preparation checklist.
Effect of Endotracheal Tube Cuff Shape on Postoperative Sore Throat After Endotracheal Intubation
Authors: Chang Jee-Eun , Kim Hyerim , Han Sung-Hee , Lee Jung-Man , Ji Sanghwan , Hwang Jin-Young 
Published: April 2017

BACKGROUND:
Although minor, a sore throat after endotracheal intubation can adversely affect patient satisfaction and postoperative function. We compared the effects of 2 endotracheal tube cuff shapes on postoperative sore throat.

METHODS:
One hundred ninety-one adult patients were included in the study. After induction of anesthesia, patients were randomized to endotracheal intubation with a conventional cylindrical-shaped cuff (Group C, n = 95) or a tapered-shaped cuff (Group T, n = 96). The number of intubation attempts, time to achieve endotracheal intubation, and duration of intubation were recorded. Postoperative sore throat and hoarseness were assessed at 1, 6, and 24 hours after surgery. A 0- to 100-mm visual analog scale was used to evaluate sore throat severity. The primary outcome of this study was the overall cumulative incidence of postoperative sore throat in the 24-hour evaluation period in the 2 groups.

RESULTS:
The overall incidence of postoperative sore throat was lower in Group T than in Group C (32% vs 54%; relative risk = 0.60, 95% confidence interval: 0.43–0.85; P= .003). At 6 hours after surgery, the incidence and severity of postoperative sore throat were lower in Group T compared with Group C (Bonferroni-corrected P< .05). Postoperative hoarseness also occurred less frequently in Group T compared with Group C (19% vs 37%; P= .006). Group T had lower incidence of hoarseness at 1 and 6 hours after surgery than Group C (Bonferroni-corrected P< .05), but the incidence of hoarseness at 24 hours after surgery did not differ between groups.

CONCLUSIONS:
Intubation using an endotracheal tube with a tapered cuff reduced the incidence and severity of postoperative sore throat and the incidence of hoarseness after surgery when compared with an endotracheal tube with a cylindrical cuff.
Spatial distribution and molecular dynamics of dystrophin glycoprotein components at the neuromuscular junction in vivo
Authors: Aittaleb Mohamed , Martinez-Pena y Valenzuela Isabel , Akaaboune Mohammed 
Published: April 2017

ABSTRACT
A bimolecular fluorescence complementation (BiFC) approach was used to study the molecular interactions between different components of the postsynaptic protein complex at the neuromuscular junction of living mice. We show that rapsyn forms complex with both α-dystrobrevin and α-syntrophin at the crests of junctional folds. The linkage of rapsyn to α-syntrophin and/or α-dystrobrevin is mediated by utrophin, a protein localized at acetylcholine receptor (AChR)-rich domains. In mice deficient in α-syntrophin, in which utrophin is no longer present at the synapse, rapsyn interaction with α-dystrobrevin was completely abolished. This interaction was completely restored when either utrophin or α-syntrophin was introduced into muscles deficient in α-syntrophin. However, in neuromuscular junctions deficient in α-dystrobrevin, in which utrophin is retained, complex formation between rapsyn and α-syntrophin was unaffected. Using fluorescence recovery after photobleaching, we found that α-syntrophin turnover is 5-7 times faster than that of AChRs, and loss of α-dystrobrevin has no effect on rapsyn and α-syntrophin half-life, whereas the half-life of AChR was significantly altered. Altogether, these results provide new insights into the spatial distribution of dystrophin glycoprotein components and their dynamics in living mice.
Marking to Market and Inefficient Investment Decisions
Authors: Otto Clemens A. , Volpin Paolo F. 
Published: April 2017

We examine how mark-to-market accounting affects the investment decisions of managers with reputation concerns. Reporting the current market value of a firm’s assets can help mitigate agency problems because it provides outsiders (e.g., shareholders) with new information against which the management’s decisions can be evaluated. However, the fact that the assets’ market value is informative can also have a negative side effect: managers may shy away from investments that indicate conflicting private information and would damage their reputation. This effect can lead to inefficient investment decisions and make marking to market less desirable when market prices are more informative. The Internet appendix is available at https://doi.org/10.1287/mnsc.2016.2696 . This paper was accepted by Gustavo Manso, finance.
Current concepts in elbow arthroplasty
Authors: Bachman Daniel , Cil Akin 
Published: April 2017

Distal humeral replacement and the total elbow are two commonly-used arthroplasties Each prosthesis has evolving indications and surgical techniques Recent changes in device design and implantation methods are due to biomechanical and clinical outcome-based research New prostheses and methods provide: better elbow kinematics, more durable bearings and longer-lasting joint replacement potentialCite this article: EFORT Open Rev 2017;2:83-88. DOI: 10.1302/2058-5241.2.160064
Rough riders in the cradle of civilization: Buffalo Bill’s Wild West show in Italy and the challenge of American cultural scarcity at the fin-de-siècle
Authors: Magrin Alessandra 
Published: April 2017

Abstract
Comparisons with European culture have often generated feelings of discomfort and anxiety in the United States. Since the age of the Enlightenment, American culture has been associated with a desert or wasteland. This conceptual inclination persisted well into the 19th century − when several American writers picked up on the perceived dearth of culture that the American intellectual landscape offered − until the Gilded Age, when the United States powerfully asserted itself as an economic and industrial power. Cultural affirmation remained, therefore, the last frontier for America to conquer. In this context, the soft power operated by Buffalo Bill Cody’s Wild West show in Europe proved to be a tremendous tool for the assertion of American cultural vitality on a worldwide scale. America’s ultimate validation, I argue, was established when Cody’s show landed in Italy, ‘the cradle of western civilization’, a stage which exuded a powerful significance in the sphere of culture, and which Cody orchestrated as a symbolic translatio imperii, by picturing himself as a Novel Columbus and America as the vessel of human progress. The resonance of Cody’s Italian tours had a regenerating effect on America; witnessing Italian culture in a moment of profound decadence fostered America’s collective confidence in its cultural superiority and confirmed its newfangled ‘exceptionalism’.
GÊNERO: REPRESENTAÇÕES DE ALUNOS DO ENSINO FUNDAMENTAL
Authors: Silva Fabio Luiz , França Cyntia Simioni 
Published: April 2017

Esse artigo objetiva descrever os resultados de uma pesquisa que investigou as representações de gênero entre alunos de escola pública, dos anos iniciais do ensino fundamental II. O estudo foi realizado em seis turmas do sexto ano do ensino fundamental, totalizando 226 alunos, dos quais 126 meninos e 100 meninas, entre 10 e 11 anos. Foi solicitado que as crianças expressassem por meio da escrita e do desenho sua opinião a respeito do que é “ser homem” e “ser mulher”. O objetivo era descobrir as representações que esses alunos tinham em relação à questão do gênero. Flagraram-se nessa atividade algumas imagens (desenhos) que trazem as vozes dos alunos acerca do que é “ser homem e o que é ser mulher” na contemporaneidade, carregadas de visões estereotipadas. A partir dos desenhos dos alunos pôde-se pensar sobre os desafios e as potencialidades de se discutir as relações entre diversidade e gênero no espaço escolar, a fim de buscar propostas de ação docente mais efetivas, no sentido de construir outro olhar para a diversidade e alterações das relações de gênero na escola e, portanto, na sociedade. Tarefa, certamente, árdua, mas possível e emergente, pois a desigualdade de gênero implica relações assimétricas de poder.