bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Early Phase of the COVID-19 Pandemic on the Quality of Care for Colorectal and Anal Cancers at Comprehensive Cancer Centers on Two Continents
Authors: Saldanha Erick F. , Powis Melanie , Sharma Divya , Espin-Garcia Osvaldo , Hack Saidah , Cavalher Felicia , Costa Maria Rita , Simoes Maria , Li Huaqi , Baiad Abed , Chen Kevin , Mohmand Zuhul , Nakhla Peter , Aguiar Samuel , Riechelmann Rachel , Krzyzanowska Monika K. 
Published: September 2024

PURPOSE
The early phase of the COVID-19 pandemic affected cancer care globally. Evaluating the impact of the pandemic on the quality of cancer care delivery is crucial for understanding how changes in care delivery may influence outcomes. Our study compared care delivered during the early phase of the pandemic with the same period in the previous year at two institutions across continents (Princess Margaret Cancer Center [PM] in Canada and A.C. Camargo Cancer Center [AC] in Brazil).

METHODS

Patients newly diagnosed with colorectal or anal cancer between February and December 2019 and the same period in 2020 were analyzed. Sociodemographic and clinical characteristics and performance of individual indicators within and between centers and between the peri–COVID-19 and control cohorts were tested using Cohen's
h
test to assess the standardized differences between the two groups.

RESULTS

Among 925 patients, distinct effects of the early COVID-19 pandemic on oncology services were observed. AC experienced a 50% reduction in patient consultations (98
v
197) versus a 12.5% reduction at PM (294
v
336). Similarly, AC experienced a higher proportion of stage IV disease presentations (42.9%
v
29.9%;
P
= .015) and an increase in treatment delay (61.9%
v
9.7%;
P
< .001) compared with prepandemic. At PM, a 10% increase in treatment interruption (32.4%
v
22.3%;
P
< .001) and a higher rate of discontinuation of radiotherapy (9.4%
v
1.1%;
P
< .001) were observed during the pandemic. Postsurgical readmission rates increased in both AC (20.9%
v
2.6%;
P
< .001) and PM (10.5%
v
3.6%;
P
< .01).

CONCLUSION
The early phase of the COVID-19 pandemic affected the quality of care delivery for colorectal and anal cancers at both centers. However, the magnitude of this impact was greater in Brazil.
Treatment Patterns and Health Care Resource Utilization of Patients With Non–Small Cell Lung Cancer in Puerto Rico: The TREATLINES-ONCOLUNG Study
Authors: Miranda Edgar I. , Gierbolini-Bermúdez Axel , Quintana Rafael , Torres-Cintrón Carlos R. , Ortiz-Ortiz Karen J. 
Published: September 2024

PURPOSE
Lung cancer remains one of the leading causes of cancer-related mortality worldwide. It is the third cause of death among patients with cancer in Puerto Rico (PR) and non–small cell lung cancer (NSCLC) is the most prevalent. This study aims to describe the first-line treatment (1LT) and health care resource utilization (HCRU) among patients with NSCLC in PR.

METHODS
A retrospective cohort study was conducted using the PR Central Cancer Registry Health Insurance Linkage Database to describe patients with NSCLC from 2012 to 2016. It describes sociodemographic and clinical characteristics on the basis of stage and histology and includes 1LT patterns and HCRU.

RESULTS
A total of 1,011 patients met the inclusion criteria. Most were male (57.1%), married (54.1%), and had no comorbidities (55.8%). A significant proportion of patients (71.1%) were diagnosed at stages III and IV, with nonsquamous cell carcinoma being the most prevalent histology group (75.9%). About 61.7% received systemic therapy, 36.7% received radiotherapy, and 21.9% underwent surgery. Platinum (Pt)-based combinations were the most common 1LT (82.9%). On average, patients had 4.7 emergency room visits, nearly six hospitalizations, and 22.4 outpatient visits annually. The mean frequencies of positron emission tomography, ultrasounds, computerized tomography scans, and magnetic resonance imaging were 0.95, 0.11, 4.88, and 0.91, respectively.

CONCLUSION
To our knowledge, this study provides the first description of 1LT patterns, HCRU, and sociodemographic information among patients with NSCLC in PR. A significant number of patients were diagnosed at stage III or higher and received Pt-based systemic therapy as their 1LT. More research is required to investigate treatment patterns beyond the 1LT and to gain a comprehensive understanding of optimal care interventions and factors associated with early NSCLC diagnosis.
Registry of Genetic Alterations of Taiwan Non–Small Cell Lung Cancer by Comprehensive Next-Generation Sequencing: A Real-World Cohort Study-Taiwan Cooperative Oncology Group T1521
Authors: Liao Bin-Chi , Chiang Nai-Jung , Chang Gee-Chen , Su Wu-Chou , Luo Yung-Hung , Chong Inn-Wen , Yang Tsung-Ying , Lai Chun-Liang , Hsia Te-Chun , Ho Ching-Liang , Lee Kang-Yun , Hsiao Chin-Fu , Ku Fan-Chen , Fang Wei-Tse , Chih-Hsin Yang James 
Published: September 2024

PURPOSE
Tissue-based next-generation sequencing (NGS) analysis is highly recommended for patients with advanced/metastatic non–small cell lung cancer (NSCLC). We investigated a specific patient population with NSCLC that required tissue-based NGS analysis.

MATERIALS AND METHODS

We enrolled 500 patients with advanced/metastatic (1) epidermal growth factor receptor (
EGFR
) mutations or anaplastic large-cell lymphoma kinase (
ALK
) rearrangement–positive NSCLC who had failed at minimum one line of tyrosine kinase inhibitor (TKI) therapy, (2)
EGFR-/ALK
-negative nonsquamous, and (3) non- or light-smoker patients with squamous NSCLC who were treatment-naïve or had failed at maximum two lines of systemic treatment. These patients were divided into five cohorts. Comprehensive tissue-based NGS testing (ACTOnco+) was conducted.

RESULTS

Cohort 1: EGFR TKI-pretreated
EGFR
-mutated population (50.0%, n = 250), cohort 2: ALK inhibitor-pretreated
ALK
-positive population (1.6%, n = 8), cohort 3: treatment-naïve
EGFR-/ALK
-negative population (28.2%, n = 141), cohort 4: pretreated
EGFR-/ALK
-negative population (16.8%, n = 84), and cohort 5: squamous cell carcinoma (3.4%, n = 17). In cohort 1, 11.2% (28/250) of the patients had
MET
amplification, 32.4% (81/250) had been treated with osimertinib, and
EGFR
C797S was detected in 6.2% (5/81) of these patients. In cohort 2, resistance ALK mutation was detected in 37.5% (3/8) of the patients. In cohorts 3 and 4, targetable genetic alterations, including
EGFR
mutation (13.3%),
ERBB2
mutation (9.3%),
MET
exon 14 skipping (5.3%),
KRAS
G12C mutation (4.4%),
ROS1
fusion (2.7%),
RET
fusion (1.8%), and
BRAF
V600E mutation (1.3%), were detected. In cohort 5,
MET
exon 14 skipping was detected in 29.4% (5/17) of the patients.

CONCLUSION
This multicenter registration study investigated tissue-based NGS for a specific patient population with NSCLC in Taiwan.
Expanding Geographical Access to Cancer Care in Botswana: Current Status and Future Prospects
Authors: Swart Norman C. , Lebelonyane Refeletswe , Gutterman Elane M. , Legwaila Morongwa , Friebel-Klingner Tara M. , Antony Reena , Mayer Tina , Sharma Kirthana , Lall Naveena , Kania Brooke , Gaolathe Tendani , Ralefala Tlotlo , Ndaba Vusikhaya , Leselwa Tapologo , Vuylsteke Peter , Marlink Richard 
Published: September 2024

PURPOSE
The growing cancer burden in Botswana has been linked to aging, lifestyle factors, and high HIV infection prevalence. The government has designated four geographically distributed hospitals as public oncology centers (POCs). A needs assessment was undertaken to ascertain the characteristics of cancer care at these centers.

METHODS
A multisite cross-sectional survey study of cancer care was conducted with oncology staff at Princess Marina Hospital (PMH), Nyangabgwe Referral Hospital (NRH), Sekgoma Memorial Hospital (SMH), and Letsholathebe II Memorial Hospital (LMH) from February to April 2021. At each POC, a focal person (experienced nurse working in oncology) identified relevant oncology staff and confirmed service availability.

RESULTS
Only PMH and NRH had a broad array of diagnostic, surgical, and treatment services. In addition, PMH was the only center with a a dedicated inpatient oncology service, a multidisciplinary committee to review patients, and a palliative care team. To support the only national cancer screening program, for cervical cancer, all POCs offered Pap tests. Mammography, available at PMH and NRH, was used solely for diagnosis. Patients from POCs requiring radiation therapy were referred to Gaborone Private Hospital at government expense. For perceived service availability, 51 staff, mainly oncologists, physicians, and nurses, were surveyed (66% based at PMH). Perceptions of services revealed a few concerns, for example, numerous staff considered hysterectomies for cervical cancer available when they were only performed at PMH.

CONCLUSION
Despite Botswana's efforts to increase the proximity of cancer services to patients, there are marked gaps, particularly at the two district-level POCs, SMH and LMH. In the future, SMH and LMH could provide selected services for specific prevalent cancers on-site, as well as follow-up and palliative care.
Risk Factors Associated With Seizure After Treatment of Chronic Subdural Hemorrhage: A Systematic Review and Meta-Analysis
Authors: Pacheco-Barrios Niels , Wadhwa Aryan , Lau Tzak S. , Shutran Max , Ogilvy Christopher S. 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Chronic subdural hemorrhage (cSDH) is a prevalent neurosurgical pathology, marked by blood collection between the dura mater and the arachnoid membrane. The aim of this systematic review was to provide a comprehensive overview of the risk factors associated with seizures after cSDH treatment.

METHODS:
We systematically searched the following databases for studies conducted until September 28, 2023: PubMed, Embase, SCOPUS, Cochrane Central, WOS, and EBSCO. We selected all studies aiming to assess risk factors associated with seizures after treatment of cSDH. Observation studies written in English, Spanish, and Portuguese were included. The quality of studies was assessed using the Newcastle-Ottawa scale for observational studies.

RESULTS:
A total of 1830 studies were screened after the elimination of duplicates. A total of 18 studies were included, representing 4966 patients. The pooled proportion of seizures after treatment of cSDH is 10% [95% CI 7%, 13%; I2 = 93%]. The risk of seizures was lower in patients undergoing burr hole surgery compared to craniotomy, with an odds ratio of 0.23 (95% CI [0.10, 0.55]; I2 = 0%). Additionally, the risk of seizures in patients receiving prophylactic antiepileptic treatment compared to those without was higher, with an odds ratio of 2.62 (95% CI [0.53, 13.06]; I2 = 66%).

CONCLUSION:
Burr-hole treatment after cSDH presents a lower risk of seizures compared with craniotomy, and the use of prophylactic antiepileptic treatment did not conclusively affect seizure outcomes. Standardization in the reporting of outcomes and more comparative studies are needed to enable better recognition of risk factors of seizures after cSDH treatment.
Allometry in limb regeneration and scale-invariant patterning as the basis of normal morphogenesis from different sizes of blastemas
Authors: Furukawa Saya , Yamamoto Sakiya , Ohashi Ayaka , Morishita Yoshihiro , Satoh Akira 
Published: September 2024

ABSTRACT
Axolotl (Ambystoma mexicanum) limb regeneration begins with blastemas of various sizes, in contrast to the limb developmental process. Despite this size variation, normal limb morphology, consistent with a limb stump size, is regenerated. This outcome suggests the existence of underlying scale-invariant mechanisms. To identify such mechanisms, we examined the allometric relationships between blastema size, and Sonic Hedgehog (Shh) and Fibroblast Growth Factor 8 (Fgf8) expression patterns against limb stump size. We found that all factors showed allometric rather than isometric scaling; specifically, their relative sizes decrease with an increase in limb stump size. However, the ratio of Shh/Fgf8 signaling dominant region was nearly constant, independent of blastema/body size. Furthermore, the relative spatial patterns of cell density and proliferation activity, and the relative position of first digit formation were scale invariant in the summed Shh/Fgf8 crosstalk region. This scale-invariant nature may underlie the morphogenesis of normal limbs from different sizes of blastemas.
Characteristics of ice cream from black soybean sprout juice – red dragon fruit with yolk emulsifier
Authors: Rahayu Wahidah Mahanani , Mustaqim Luthfi , Khairi Amalya Nurul , Permadi Adi , Hidayah Nurul 
Published: September 2024

Black soybean germination into sprouts reportedly improved nutrition digestibility and bioactive compound content. Red dragon fruit (RDF) and egg yolk (EY) can be used as natural and halal colorants and emulsifiers. Black soybean sprout (BSS) juice made non-dairy ice cream with red dragon fruit and egg yolk as an emulsifier. This research aimed to measure the effect of various red dragon fruit and egg yolk concentrations on the characteristics of ice cream made from BSS juice. A completely randomized design was applied to six formulations made using the ratio of RDF : EY of FA (20%: 3%), FB (20%: 4%), FC (20%: 5%), FD (40%: 3%), FE (40%: 4%), and FF (40%: 5%). BSS juice was made using 48 hours of room temperature incubated sprout and water at a 1:4 (b/v) ratio. Filtrate was then mixed with sugar, cornstarch, and salt into a dough, which was then mixed with RDF and EY at various concentrations. Nutritional proximate composition, radical scavenging activity, phenolic content, total anthocyanin content, vitamin C, and sensory acceptance were analyzed. Data was then statistically analyzed using one-way ANOVA, followed by Duncan’s Multiple Range Test. Results showed that higher RDF significantly changed overrun, melting rate, increased moisture content, vitamin C (20.4 – 40.23 mg/100 g), antioxidant activity (34.9 – 62.78 % radical scavenging activity), total phenolics (0.341 – 0.536 mg/g GAE), and total anthocyanin (3.905 – 9.726 mg/kg), and hedonic score, but shorter melting time. The shortest melting time was obtained by ice cream made using 20% RDF and 5% EY, the lower concentration of fruit, and the highest concentration of egg yolk, respectively. The results indicated that BSS juice could be used as the main ingredient to make non-dairy ice cream, with red dragon fruit and egg yolk as natural colorants and emulsifiers, respectively.

Keywords: Black soybean sprout, Non-dairy ice cream, Red dragon fruit
The factors that affect halal certification among small and medium enterprise food entrepreneurs in Ngawi
Authors: Luthfiya Lulu' , Damayanti Amilia Yuni , Pibriyanti Kartika , Marfu'ah Nurul , Mufidah Indahtul , Amala Nur , Hafifah Cut Ajma Fitira , Fauziatunnisa Elok 
Published: September 2024

A halal lifestyle using halal-certified products is a vital necessity for Muslims. It allows Indonesia to become the world's largest producer and servicer of halal products. However, many uncertified halal products are circulating in the community, and the number of certified halal items tends to be small. Several factors influence the low quality of halal certification products. This Research aimed to identify factors influencing halal certification: education, knowledge, attitudes, behavior, and awareness. The Type of research was crossectional research. The research was conducted in the Ngawi district by comparing entrepreneurs with halal certification and entrepreneurs who still need to have halal certification, with the number of each sample of 26 entrepreneurs. The technique of sampling was purposive sampling. These research variables are factors associated with halal certification, including the level of education, knowledge, attitudes, behavior, and awareness of the entrepreneur acquired through interviews using validated questionnaires and the reliability of the questionnaire. The education, knowledge, and attitude data were analyzed using a chi-square test. The behavior and halal awareness were analyzed using the Fisher test. The statistical test results showed a p-value of < 0.001 on the variables of knowledge, education, attitude, and behavior, so it can be said that knowledge, education, behavior, and attitude positively affect halal certification. However, based on the statistical test on the halal awareness variable, the relationship test results of p-value > 0.05, so it can be said that halal awareness does not positively affect halal certification. This research concludes that education, knowledge, attitudes, and behavior influence legal certification. Awareness of halal behavior does not affect halal certification.

Keywords: Attitude, Behavior, Education, Halal awareness, Halal certification knowledge
Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins
Authors: Ruzhanskaya Anna , Ichihara Kiyoshi , Sukhacheva Elena , Skibo Irina , Vybornova Nina , Butlitski Dmitry , Vasiliev Anton , Agarkova Galina , Vilenskaya Ekaterina , Emanuel Vladimir , Lugovskaya Svetlana 
Published: September 2024

Objectives
This study aimed to establish reference intervals (RIs) for Russian adults for hematological parameters including related iron markers and vitamins. Sources of variation of reference values (RVs) and needs for secondary exclusion were explored for proper derivations of RIs.

Methods
Following the harmonized protocol of the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL), 506 healthy Russians (age 18−80; 46% male) were recruited. Complete blood counts (CBC) and leukocyte differentials, iron markers, vitamin B12, and folate were measured by Beckman Coulter’s analyzers. Sources of variation were analyzed by multiple regression analysis, and ANOVAs, and the need for partitioning RVs was decided accordingly. Two schemes of excluding latent anemia were compared: (1) latent abnormal values exclusion method (LAVE) based on associations among CBC parameters, or (2) explicit exclusion of individuals with either ferritin or iron below the respective lower limit of the manufacturer. RIs were determined by the parametric method using two-parameter Box-Cox formula.

Results
Gender-specific RIs were required for most analytes, while age-specific RIs were set only for ferritin in females. A BMI-related increase in RVs was prominently observed for reticulocyte parameters, hence we chose to exclude individuals with BMI>28 kg/m2 when establishing the RIs. The LAVE method was more effective in excluding individuals with latent anemia, than exclusion based on low ferritin and/or iron values. International comparison revealed that Russian RIs featured a lower side shift of platelet counts. Similar to African countries, Russian RIs for total leukocyte and neutrophil counts were lower compared to most of other countries.

Conclusion
RIs for the Russian population for 34 hematological and related parameters were established using up-to-date methods proposed by C-RIDL. Reducing the influences of latent anemia and obesity on RIs was crucial for erythrocyte parameters. Low levels of Russian RIs observed for platelet and neutrophil counts need further investigation.
The crystal structure of 2,3-di(pyridin-2-yl)-2,3-dihydroquinazolin-4(1H)-one, C18H14N4O
Authors: Liu Sheng-Jie , Zhang Ying , Yuan Lin , Chen Xiao-Ming 
Published: September 2024

Abstract
C18H14N4O, orthorhombic, Pbca (no. 61), a = 7.963(3) Å, b = 12.629(5) Å, c = 30.116(11) Å, V = 3,028.3(19) Å3, Z = 8, R

gt
(F) = 0.0475, wR

ref
(F
2) = 0.1444, T = 296(2) K.
Transformer-based approaches for neuroimaging: an in-depth review of their role in classification and regression tasks
Authors: Zhu Xinyu , Sun Shen , Lin Lan , Wu Yutong , Ma Xiangge 
Published: September 2024

Abstract
In the ever-evolving landscape of deep learning (DL), the transformer model emerges as a formidable neural network architecture, gaining significant traction in neuroimaging-based classification and regression tasks. This paper presents an extensive examination of transformer’s application in neuroimaging, surveying recent literature to elucidate its current status and research advancement. Commencing with an exposition on the fundamental principles and structures of the transformer model and its variants, this review navigates through the methodologies and experimental findings pertaining to their utilization in neuroimage classification and regression tasks. We highlight the transformer model’s prowess in neuroimaging, showcasing its exceptional performance in classification endeavors while also showcasing its burgeoning potential in regression tasks. Concluding with an assessment of prevailing challenges and future trajectories, this paper proffers insights into prospective research directions. By elucidating the current landscape and envisaging future trends, this review enhances comprehension of transformer’s role in neuroimaging tasks, furnishing valuable guidance for further inquiry.
Sodium alginate edible films incorporating cactus pear extract: antimicrobial, chemical, and mechanical properties
Authors: A. Asiri Saeed , Matar Amal , Mahmoud Ismail Ahmed , Farag Hoda A. S. 
Published: September 2024

The potential benefits of biodegradable and functional food packaging materials have garnered increasing attention in recent years. Sodium alginate (SA), a commonly utilized polysaccharide, is particularly noteworthy for producing biodegradable films for food packaging. This study aimed to investigate SA-based edible films enriched with various proportions of cactus pear peel extract (CPPE). We assessed the films and extracts for total phenolic content, antimicrobial and antioxidant activities, as well as mechanical properties. Cactus pear peels powder (CPPP) exhibited higher contents of total polyphenols (1243.82 mg GAE/100 g), total flavonoids (18.92 mg QE/100 g), and betalains (2.28 mg/100 g). The main constituents detected were catechol, pyrogallol, catechin, and alpha-coumaric acid, with concentrations of 1013.82, 223.45, 148.21, and 101.02 ppm, respectively, contributing about 45.71%, 9.85%, 6.54%, and 4.46% of the total phenolic compounds. The thickness of the SA films increased from 0.220 mm to 0.265 mm. The tensile strength values ranged from 1.98 to 3.12, while the elongation at break values for SA-CPPE films decreased relative to the plain SA film. Moreover, the inclusion of CPPE improved the barrier characteristics (with water vapor permeability values for SA films with 1%, 2%, and 3% CPPE ranging from 0.72 × 10−5 g•h−1•m−1•Pa−1 to 1.68 × 10−5 g•h−1•m−1•Pa−1) and induced variations in flexibility and resistance. The plain SA film did not exhibit any inhibitory activity against bacteria and fungi. However, the inclusion of CPPE in alginate films showed favorable antibacterial properties, which improved progressively with increasing CPPE concentration. These findings highlight the potential of incorporating active alginate-based films in food preservation.