bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of dual‐specificity phosphatase‐2 promotes angiogenesis and metastasis via up‐regulation of interleukin‐8 in colon cancer
Authors: Lin Shih‐Chieh , Hsiao Kuei‐Yang , Chang Ning , Hou Pei‐Chi , Tsai Shaw‐Jenq 
Published: December 2016

AbstractDual‐specificity phosphatase 2 (DUSP2) is a negative regulator of mitogen‐activated protein kinases. Our previous study showed that DUSP2 expression is down‐regulated in many human cancers and loss of DUSP2 promotes cancer progression; however, the underlying mechanism remains largely uncharacterized. Herein, we found that loss of DUSP2 induces angiogenesis, while forced expression of DUSP2 inhibits microvessel formation in xenografted mouse tumours. Genome‐wide screening of expression profiles, and meta‐analysis of clinical data, identified that the level of interleukin‐8 (IL‐8) correlated negatively with that of DUSP2, suggesting that it may be a downstream target of DUSP2. Molecular characterization revealed that DUSP2 inversely regulates IL‐8 expression, mediated by ERK1/2 and C/EBPα‐dependent transcriptional regulation. Further study showed that hypoxia‐induced IL‐8 expression in cancer cells is also mediated via down‐regulation of DUSP2. Treatment with the IL‐8 receptor inhibitor reparixin or knockdown of IL‐8 in cancer cells abolished angiogenesis induced by loss of DUSP2. Functionally, knockdown of DUSP2 enhanced tumour growth and metastasis, which were abolished by treatment with reparixin or knockdown of IL‐8 in an orthotopic mouse model. Taken together, our results demonstrate that hypoxia inhibits DUSP2 expression in colon cancer, leading to up‐regulation of IL‐8, which facilitates angiogenesis and tumour metastasis. Our findings suggest that blocking hypoxia–DUSP2–IL‐8 signalling may be a plausible approach for therapeutic intervention in cancer. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Effects of long‐term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice
Authors: Müller Mike F , Zhou Ying , Adams David J , Arends Mark J 
Published: December 2016

AbstractEthanol and its metabolite acetaldehyde have been classified as carcinogens for the upper aerodigestive tract, liver, breast, and colorectum. Whereas mechanisms related to oxidative stress and Cyp2e1 induction seem to prevail in the liver, and acetaldehyde has been proposed to play a crucial role in the upper aerodigestive tract, pathological mechanisms in the colorectum have not yet been clarified. Moreover, all evidence for a pro‐carcinogenic role of ethanol in colorectal cancer is derived from correlations observed in epidemiological studies or from rodent studies with additional carcinogen application or tumour suppressor gene inactivation. In the current study, wild‐type mice and mice with depletion of aldehyde dehydrogenase 1b1 (Aldh1b1), an enzyme which has been proposed to play an important role in acetaldehyde detoxification in the intestines, received ethanol in drinking water for 1 year. Long‐term ethanol consumption led to intestinal tumour development in wild‐type and Aldh1b1‐depleted mice, but no intestinal tumours were observed in water‐treated controls. Moreover, a significant increase in DNA damage was detected in the large intestinal epithelium of ethanol‐treated mice of both genotypes compared with the respective water‐treated groups, along with increased proliferation of the small and large intestinal epithelium. Aldh1b1 depletion led to increased plasma acetaldehyde levels in ethanol‐treated mice, to a significant aggravation of ethanol‐induced intestinal hyperproliferation, and to more advanced features of intestinal tumours, but it did not affect intestinal tumour incidence. These data indicate that ethanol consumption can initiate intestinal tumourigenesis without any additional carcinogen treatment or tumour suppressor gene inactivation, and we provide evidence for a role of Aldh1b1 in protection of the intestines from ethanol‐induced damage, as well as for both carcinogenic and tumour‐promoting functions of acetaldehyde, including increased progression of ethanol‐induced tumours. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Care‐related predictors for negative intrusive thoughts after prostate cancer diagnosis—data from the prospective LAPPRO trial
Authors: Thorsteinsdottir Thordis , Valdimarsdottir Heiddis , Hauksdottir Arna , Stranne Johan , Wilderäng Ulrica , Haglind Eva , Steineck Gunnar 
Published: December 2016

AbstractObjectiveNegative intrusive thoughts about one's prostate cancer have been associated with depressive mood and impaired quality of life among prostate cancer patients. However, little is known about possible predictors for negative intrusive thoughts among this group. We aimed to identify health‐ and care‐related predictors for such thoughts among a population of men newly diagnosed with prostate cancer and undergoing radical prostatectomy.MethodsIn the LAPPRO‐trial, 3154 men (80%) answered study‐specific questionnaires at admission and 3 months after surgery. Questions concerned socio‐demographics, health, uncertainty, preparedness for symptoms, and the outcome—negative intrusive thoughts. Associations between variables were analyzed by log‐binominal and multivariable approach.ResultsThe strongest predictor of negative intrusive thoughts at admission to surgery was uncertainty of cure, followed by binge drinking, poor physical health, antidepressant medication, not being prepared for urinary symptoms, age under 55, and physical pain. Reporting it not probable to obtain urinary symptoms after surgery lowered the odds. Negative intrusive thoughts before surgery were the strongest predictor for such thoughts 3 months later followed by uncertainty of cure, physical pain, younger age, living alone, and poor self‐reported physical health.ConclusionsOur findings showed an association of preoperative uncertainty of cure as well as low preparedness for well‐known surgery‐induced symptoms with higher occurrence of negative intrusive thoughts about prostate cancer. Future studies should examine if interventions designed to have healthcare professionals inform patients about their upcoming prostatectomy reduce patients' negative intrusive thoughts and thereby, improve their psychological well‐being.
Information work in information science research and practice
Authors: Huvila Isto , Lloyd Annemaree , Budd John M. , Palmer Carole , Toms Elaine 
Published: December 2016

ABSTRACTInformation science and technology researchers and practitioners discuss information activities a broad range of terms. A concept that often appears in colloquial discussions of information activities but that has received less systematic attention is that of information work. This panel gathers a group of information science researchers who have explicitly used the notion of information work in their research to discuss how the concept can inform information science and technology research, and practice.
ALISE/ASIST Joint panel on accreditation: Moving forward with LIS accreditation reform
Authors: Ross Seamus , Connaway Lynn S. , Spiteri Louise , Hepburn Peter , Caidi Nadia , Eschenfelder Kristin 
Published: December 2016

ABSTRACTThe landscape of education in Library and Information Science (LIS) is shifting as the ways in which information is managed and used in society evolves. As these changes happen how we validate our educational programs needs to change as well. Discussion about the ways in which accreditation of LIS education programs is currently conducted has become an increasingly contested issue within the Information community. This panel will examine the current approaches to accreditation, sketch the progress that has been made on accreditation reform, consider what educational institutions and the LIS community are seeking to achieve with accreditation, and conclude by considering the next steps for ASIS&T and the information community as we press forward with efforts to reform accreditation.
Preserving intangible heritage: Defining a research agenda
Authors: Bonn Maria , Kendall Lori , McDonough Jerome 
Published: December 2016

ABSTRACTThe past decade has seen tremendous progress in the field of preservation, particularly with respect to preservation of digital materials. To date, however, there has been only minimal research activity within North America on the preservation of intangible cultural heritage, and its relationship to the preservation of material expressions of culture. Given the importance of intangible heritage to the cultural and scholarly record, we believe that a more significant research program in this area would be of benefit to the scholarly community. This panel will focus on the nature of intangible heritage and the problems in preserving it in a digital age.
Social informatics of data norms
Authors: McCoy Chase , Marcinkowski Michael , Sawyer Steve , Sanfilippo Madelyn R. , Meyer Eric T. , Rosenbaum Howard 
Published: December 2016

ABSTRACTBig data has been widely promoted across disciplines and sectors for its potential to enhance lives and promote knowledge discovery. However, challenges arise at all stages of the data lifecycle due to the complexity of interactions between data and the contexts within which they are collected and managed, which has implications for interpretations of this data and eventual use of information and the creation of knowledge products from these data. Starting from the perspective of social informatics, this panel will discuss: the reciprocal relationships between data and context; specific challenges in distinct stages of data generation, data repository implementation, data curation, data use, and data reproducibility; and the implications of these challenges and their potential solutions for both social informatics research and society in general.
Digital liaisons virtual uncommons: Creating knowledge, enhancing lives via digital libraries
Authors: Cunningham Christopher A , Grguric Ekatarina , Gamble Alyson 
Published: December 2016

ABSTRACTDigital libraries are uniquely poised as environments for knowledge creation and life enhancement. Researchers are able to develop and utilize the virtual environment in compelling ways, including global engagement with people who are new to practicing information science. Virtual sessions and unconferences are two innovative ways to connect established practitioners with less experienced students and professionals in supportive, collaborative environments. By combining these two formats, we propose hosting a virtual uncommons that transcends geographical locations. The Digital Liaisons Virtual Uncommons (DLVU) will feature leaders in digital libraries who will act in a mentoring capacity by responding to questions posed by new information professionals.In the DLVU, innovative students and early career professionals will be able to connect with mentors in the field of digital librarianship. The virtual uncommons will be a space for informal mentoring and serendipitous networking. This session will feature a Twitter chat under the hashtag #SIGDLchats (OR #DL4Good) for LIS students and newly practicing professionals to connect with mentors in the field with a focus on the changing nature of modern librarianship. Mentors will be sought out beforehand and the session will be widely publicized to international LIS, IS, Archival, etc. I‐*, programs.
Tomato tomahto: European perspectives on information science
Authors: Warner Julian , Ibekwe‐SanJuan Fidelia , Peters Isabella , Lund Niels Windfeld , Buckland Michael 
Published: December 2016

ABSTRACT'And oh, if we ever part, then that might break my heart’ (Gershwin and Gershwin, ).In the lyric, ‘tomato tomahto', the marked, or explicitly differentiated term, is tomahto, corresponding more to the English rather than the United States pronunciation. The marked term of a contrast characteristically designates the exception or minor term and the distinctions contained in the unmarked term may be implicitly, and incompletely, understood. Analogously, information science has often been implicitly based in the United States and influenced by American modes of thought, while European, including English, developments have been the occasionally marked and often minor term.This panel explores European perspectives on information science, explicitly and implicitly contrasting them with United States perspectives, from a base in a number of languages and in Europe and beyond.The panel employs diverse and complementary viewpoints and should make for a lively discussion. It concludes, in sympathy with Gershwin, that cooperation and integration, corresponding to increasing globalization, is the way forward.The combination of European and beyond and United States perspectives on information science is especially appropriate for the first ASIS&T Annual Meeting outside North America.
Global/local knowledge organization: Contexts and questions
Authors: Adler Melissa A. , Tennis Joseph T. , Martínez‐Ávila Daniel , Guimarães José Augusto C. , Mai Jens‐Erik , Olesen‐Bagneux Ole , Skouvig Laura 
Published: December 2016

ABSTRACTThis panel features junior and senior scholars from the United States, Denmark, and Brazil, who will come together to discuss some of the central tensions between local and global knowledge organization systems. They will be in conversation around three key questions: 1) What are the contexts in which local and global knowledge organization systems matter? 2) What can we learn about the stakes of global/local knowledge organization from those contexts? 3) How can we conceptualize the relationship between the universal and the particular? The panelists will provide brief overviews of their perspectives, and the majority of the time will be reserved for an interactive discussion of the epistemological, practical, and ethical dimensions of global and local knowledge organization. The contexts addressed will include libraries, archives, and digital, social, and popular media. Within those settings, the panelists are concerned with such issues as access, hegemony, intended and unintended consequences, and meaning construction in particular domains, spaces, and communities.
Dismantling information poverty in cultural production for young people
Authors: Cooke Nicole A. , Martens Marianne , Junker Beth 
Published: December 2016

ABSTRACTThis panel, comprised of an international team of scholars, will address children's information poverty from three perspectives: 1) information poverty faced by populations who do not see themselves reflected within mainstream picture books; 2) information poverty faced by immigrant children who do not have access to appropriate learning materials; and 3) adults' cultural information poverty around the meaning of young people's encounters with art and culture as part of their everyday life experience.
Publish or perish: Meet the editors a special panel
Authors: Beheshti Jamshid , Jansen Jim , Dillon Andrew , Lewandowski Dirk , Mostafa Javad , Khanova Julia , Wilson Tom , Seadle Michael 
Published: December 2016

ABSTRACTThis is a special panel to introduce the editors of prestigious international journals in library and information science, who will discuss the aim and the scope of the journals and elaborate on the expectations from potential contributors to help young academics understand and appreciate the process of academic publishing.
Making research data possible: Negotiating between disciplinary cultures, temporalities, data policies, professional interests and education and training
Authors: Kjellberg Sara , Cox Andrew , Tammaro Anna Maria , Haider Jutta , Tam Winnie , Matusiak Krystyna K. 
Published: December 2016

ABSTRACTThe workshop brings together differing perspectives on what makes research data possible. How data is made represents an on‐going negotiation between a number of elements. It reflects, firstly, the nature of disciplines and the complex way this is linked to cultures of research data and data sharing. Secondly, data is made across the complex temporalities within different practices of its management. Thirdly, it increasingly reflects the influences of data policies: working at the international and national, down to institutional level. Fourthly, it is also shaped by the renegotiation of professional interests and relationships such as between librarians, computing services, archivists and research administrators. And, fifthly, data is being shaped within models of education and training of current and new information professionals. The panel seeks to bring together a diverse range of participants to explore appropriate theories and methodologies for work in this field, using a conversation cafe format, and based on discussions around the five elements.
Qualitative methods for studying health information behaviors
Authors: Oh Sanghee , Costello Kaitlin L. , Chen Annie T. , Wildemuth Barbara M. 
Published: December 2016

ABSTRACTQualitative methods can be used to understand and interpret human behaviors in a variety of contexts, including people's health information behaviors. This panel will discuss current applications of qualitative methods in this context, with emphasis on three examples: visual elicitation techniques, qualitative content analysis, and grounded theory approaches. The audience will be encouraged to discuss additional qualitative approaches and mixed methods, and how they might be applied to studies of health information behaviors.
Media format matters: Users' perceptions of physical versus digital games
Authors: Lee Jin Ha , Holmes Dylan , Lobe Brooks 
Published: December 2016

ABSTRACTDespite the rapid shift in media distribution from physical to digital formats, few studies explore what this means to users with regards to perceived values, limitations, and experience with media. We investigate this problem, specifically within the context of video games, aiming to understand which formats game players prefer and for what reasons, and the implications for game content providers and digital libraries. The findings from a survey of 1,257 game players showed that more respondents preferred digital formats over physical formats. Advocates of digital games typically valued accessibility and convenience, longevity of games free of physical damage, less need for storage, and reduced cost. Advocates of physical games generally valued the ability to easily retrieve, share, and resell games, ownership and longevity of access to games, the paraphernalia and collectibles that came with physical games, and the aesthetic and tangible qualities of the physical object. We discuss the implications of these findings for content providers and libraries, with an emphasis on game preservation efforts.
Affective taxomonies of the reading experience: Using user‐generated reviews for readers' advisory
Authors: Spiteri Louise F. , Pecoskie Jen 
Published: December 2016

ABSTRACTThis paper examines affect in the reading experience to help both readers' advisors and readers as they work to suggest books to readers and choose books for their individual context. Using Grounded Theory analysis of 536 user‐generated reviews from 831 bibliographic records of a selection of fiction titles (n=22) in Canadian public libraries whose catalogues allow for the inclusion of user content were analyzed for affective content. The content of the reviews was coded into three categories, Emotions, Tones, and Associations and taxonomies were developed. Emotions are represented by 9 basic categories, and 44 unique emotions, Tones by 11 basic categories and 141 unique tones, and Associations by 7 basic categories and 31 unique associations. Affective access points can serve as an important addition to the bibliographic records for works of fiction and it is suggested that the derived taxonomies could be used as facets by which to narrow the results of a search for readers' advisory efforts in public libraries.
Plagiarism‐free inquiry project‐based learning with UPCC pedagogy
Authors: Lee Celina Wing Yi , Chu Samuel Kai Wah , Cheng Joanna Oi Yue , Reynolds Rebecca 
Published: December 2016

ABSTRACT(U)nderstanding plagiarism, learning about (P)araphrasing and related skills, generating proper (C)itations with an online citation tool and doing originality (C)heck with an online tool (UPCC) is a pedagogy developed by Chu and his colleagues (, ) to help students avoid plagiarism. The UPCC pedagogy incorporates teaching the ethical use of information, an important facet of information literacy, into inquiry project‐based learning (PjBL), a pedagogical approach that demands students to demonstrate high order information literacy. This study, adopting a mixed‐methods design, evaluates the effectiveness of UPCC by comparing the plagiarism behavior of two cohorts of junior secondary students in their PjBL projects with and without the implementation of the pedagogy. In addition, upon the completion of their projects, the 2015 cohort completed a survey that evaluates their knowledge of plagiarism, and assesses the extent to which they endorse the helpfulness of the UPCC in domains including instructional support; understanding plagiarism; paraphrasing, synthesizing and summarizing; generating appropriate citations; and originality self‐check. Students and teachers also participated in focus group interviews to further elaborate on their perceptions on the UPCC pedagogy. A trend in reduced plagiarism behavior was observed after the implementation of UPCC, and students expressed a generally positive perception on UPCC as an effective anti‐plagiarism pedagogy. Quantitative and qualitative data showed that students who had better knowledge of plagiarism held a significantly more positive perception on the effectiveness of UPCC than those who showed poorer understanding of plagiarism. This may indicate that further refinement of UPCC is needed to cater for learner diversity and enhance students' motivation.
Enhancing lives through information and technology: Watson davis's project for information organisation and dissemination
Authors: Mendes Luciana Corts 
Published: December 2016

ABSTRACTThis paper gives a summary of the activities of Watson Davis (1896–1967) during the first half of the 20th century in the area of information organisation and dissemination. Starting from Davis's views on the purpose of information, the paper subsequently describes his projects for the establishment of “one big library”, the Auxiliary Publication Service, “one big journal”, and the “world brain”. Considering Davis as a member of the Special Libraries and Documentation Movement, his connections with its other members are explored. Subsequently, Davis's ideas are analysed and his legacy to Information Science investigated. The paper argues that Davis is an important link between Information Science and its predecessor Documentation, and therefore that he deserves to be subject of deeper research.