bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination and Safety Assessment of Residual Spirotetramat and Its Metabolites in Amaranth (Amaranthus tricolor) and Soil by Liquid Chromatography Triple-Quadrupole Tandem Mass Spectrometry
Authors: Chen Xiao-Jun , Meng Zhi-Yuan , Ren Li , Song Yue-Yi , Ren Ya-Jun , Chen Jian-Shu , Guan Ling-Jun 
Published: October 2017

Abstract
With the purpose of guaranteeing the safe use of spirotetramat and preventing its potential health threats to consumers, a QuEChERS extraction method coupled with LC triple-quadrupole tandem MS was applied in this study to determine residual spirotetramat metabolites in different tissues of amaranth (Amaranthus tricolor) and in soil. The results indicate that the spirotetramat degraded into different types of metabolites that were located in different tissues of amaranth and in soil. B-keto, B-glu, and B-enol were the three most representative degradation products in the leaf of amaranth, and B-glu and B-enol were the two major degradation products found in the stem of amaranth; however, only B-enol was detected in the root of amaranth. B-keto and B-mono were the two products detected in the soil in which the amaranth grew. The cytotoxicity results demonstrate that spirotetramat and its metabolite B-enol inhibited cellular growth, and the toxicity of spirotetramat and its metabolite B-enol exceeded than that of the metabolites B-keto, B-mono, and B-glu. This investigation is of great significance to the safe use of spirotetramat in agriculture.
Enhanced conflict monitoring via a short-duration, video-assisted deep breathing in healthy young adults: an event-related potential approach through the Go/NoGo paradigm
Authors: Cheng Kok Suen , Chang Yun Fah , Han Ray P.S. , Lee Poh Foong 
Published: October 2017

Objectives
Practitioners of mindfulness are reported to have greater cognitive control especially in conflict monitoring, response inhibition and sustained attention. However, due to the various existing methods in each mindfulness practices and also, the high commitment factor, a barrier still exists for an individual to pick up the practices. Therefore, the effect of short duration deep breathing on the cognitive control is investigated here.

Methods
Short duration guided deep breathing videos consisting of 5, 7 and 9 min respectively were created and used on subjects training. The effect on cognitive control was assessed using a Go/NoGo task along with event-related potential (ERP) measurements at Fz, Cz, and Pz.

Results
From the study, the significant outcome showed at the follow-up session in which participants engaged for 5 min deep breathing group showed a profound NoGo N2 amplitude increment as compared to the control group, indicating an enhanced conflict monitoring ability. An inverse relationship between the NoGo N2 amplitude and the breathing duration is observed as well at the follow-up session.

Conclusion
These results indicated the possibility of performing short duration deep breathing guided by a video to achieve an enhanced conflict monitoring as an alternative to other mindfulness practices and 5 min is found to be the optimum practice duration.

Significant
This study is the first to establish a relationship between deep breathing and conflict monitoring through ERP. The study population of young adults taken from the same environment reduces the variance in ERP results due to age and environment.

Limitation
A larger sample size would provide a greater statistical power. A longer duration of deep breathing should be investigated to further clarify the relationship between the practice duration and the NoGo N2 amplitude. The result can be split by gender and analyzed separately due to the different brain structure of males and females.
Benchmark datasets for phylogenomic pipeline validation, applications for foodborne pathogen surveillance
Authors: Timme Ruth E. , Rand Hugh , Shumway Martin , Trees Eija K. , Simmons Mustafa , Agarwala Richa , Davis Steven , Tillman Glenn E. , Defibaugh-Chavez Stephanie , Carleton Heather A. , Klimke William A. , Katz Lee S. 
Published: October 2017

Background
As next generation sequence technology has advanced, there have been parallel advances in genome-scale analysis programs for determining evolutionary relationships as proxies for epidemiological relationship in public health. Most new programs skip traditional steps of ortholog determination and multi-gene alignment, instead identifying variants across a set of genomes, then summarizing results in a matrix of single-nucleotide polymorphisms or alleles for standard phylogenetic analysis. However, public health authorities need to document the performance of these methods with appropriate and comprehensive datasets so they can be validated for specific purposes, e.g., outbreak surveillance. Here we propose a set of benchmark datasets to be used for comparison and validation of phylogenomic pipelines.

Methods
We identified four well-documented foodborne pathogen events in which the epidemiology was concordant with routine phylogenomic analyses (reference-based SNP and wgMLST approaches). These are ideal benchmark datasets, as the trees, WGS data, and epidemiological data for each are all in agreement. We have placed these sequence data, sample metadata, and “known” phylogenetic trees in publicly-accessible databases and developed a standard descriptive spreadsheet format describing each dataset. To facilitate easy downloading of these benchmarks, we developed an automated script that uses the standard descriptive spreadsheet format.

Results
Our “outbreak” benchmark datasets represent the four major foodborne bacterial pathogens (Listeria monocytogenes, Salmonella enterica, Escherichia coli, and Campylobacter jejuni) and one simulated dataset where the “known tree” can be accurately called the “true tree”. The downloading script and associated table files are available on GitHub: https://github.com/WGS-standards-and-analysis/datasets.

Discussion
These five benchmark datasets will help standardize comparison of current and future phylogenomic pipelines, and facilitate important cross-institutional collaborations. Our work is part of a global effort to provide collaborative infrastructure for sequence data and analytic tools—we welcome additional benchmark datasets in our recommended format, and, if relevant, we will add these on our GitHub site. Together, these datasets, dataset format, and the underlying GitHub infrastructure present a recommended path for worldwide standardization of phylogenomic pipelines.
Three‐Dimensional Seismic Imaging of Ancient Submarine Lava Flows: An Example From the Southern Australian Margin
Authors: Reynolds P. , Holford S. , Schofield N. , Ross A. 
Published: October 2017

AbstractSubmarine lava flows are the most common surficial igneous rock on the Earth. However, they are inherently more difficult to study than their subaerial counterparts due to their inaccessibility. In this study, we use newly acquired 3‐D (three‐dimensional) seismic reflection data to document the distribution and morphology of 26 ancient, buried lava flows within the middle Eocene‐aged Bight Basin Igneous Complex, offshore southern Australia. Many of these lava flows are associated with volcanoes that vary from 60 to 625 m in height and 0.3 to 10 km in diameter. Well data and seismic‐stratigraphic relationships suggest that the lava flows and volcanoes were emplaced offshore in water depths of <300 m. The lava flows range from 0.5 to 34 km in length and 1 to 15 km in width and are typified by tabular and dendritic forms. This morphological variation may result from differing lava effusion rates and/or the volumes of lava erupted. We demonstrate that: (1) the dendritic flows contain complex lava distribution systems and kipukas, features never‐before observed from seismic data; and (2) the distribution and morphology of the lava flows was strongly controlled by the emplacement of magmatic intrusion‐induced forced folds. This suggests that magmatic intrusions may play an important role in controlling the distribution of lava flows elsewhere. Our study highlights the usefulness of seismic data in studying the manifestation of submarine volcanism, and provides quantitative data on the extent and distribution of an ancient submarine volcanic province along the southern Australian margin.
Effect of Snow Salinity on CryoSat‐2 Arctic First‐Year Sea Ice Freeboard Measurements
Authors: Nandan Vishnu , Geldsetzer Torsten , Yackel John , Mahmud Mallik , Scharien Randall , Howell Stephen , King Joshua , Ricker Robert , Else Brent 
Published: October 2017

AbstractThe European Space Agency's CryoSat‐2 satellite mission provides radar altimeter data that are used to derive estimates of sea ice thickness and volume. These data are crucial to understanding recent variability and changes in Arctic sea ice. Sea ice thickness retrievals at the CryoSat‐2 frequency require accurate measurements of sea ice freeboard, assumed to be attainable when the main radar scattering horizon is at the snow/sea ice interface. Using an extensive snow thermophysical property dataset from late winter conditions in the Canadian Arctic, we examine the role of saline snow on first‐year sea ice (FYI), with respect to its effect on the location of the main radar scattering horizon, its ability to decrease radar penetration depth, and its impact on FYI thickness estimates. Based on the dielectric properties of saline snow commonly found on FYI, we quantify the vertical shift in the main scattering horizon. This is found to be approximately 0.07 m. We propose a thickness‐dependent snow salinity correction factor for FYI freeboard estimates. This significantly reduces CryoSat‐2 FYI retrieval error. Relative error reductions of ~11% are found for an ice thickness of 0.95 m and ~25% for 0.7 m. Our method also helps to close the uncertainty gap between SMOS and CryoSat‐2 thin ice thickness retrievals. Our results indicate that snow salinity should be considered for FYI freeboard estimates.
Empirical Model of Precipitating Ion Oval
Authors: Goldstein Jerry 
Published: October 2017

AbstractIn this brief technical report published maps of ion integral flux are used to constrain an empirical model of the precipitating ion oval. The ion oval is modeled as a Gaussian function of ionospheric latitude that depends on local time and the Kp geomagnetic index. The three parameters defining this function are the centroid latitude, width, and amplitude. The local time dependences of these three parameters are approximated by Fourier series expansions whose coefficients are constrained by the published ion maps. The Kp dependence of each coefficient is modeled by a linear fit. Optimization of the number of terms in the expansion is achieved via minimization of the global standard deviation between the model and the published ion map at each Kp. The empirical model is valid near the peak flux of the auroral oval; inside its centroid region the model reproduces the published ion maps with standard deviations of less than 5% of the peak integral flux. On the subglobal scale, average local errors (measured as a fraction of the point‐to‐point integral flux) are below 30% in the centroid region. Outside its centroid region the model deviates significantly from the H89 integral flux maps. The model's performance is assessed by comparing it with both local and global data from a 17 April 2002 substorm event. The model can reproduce important features of the macroscale auroral region but none of its subglobal structure, and not immediately following a substorm.
General and Abdominal Obesity as Risk Factors for Late‐Life Mobility Limitation After Total Knee or Hip Replacement for Osteoarthritis Among Women
Authors: Shadyab Aladdin H. , Li Wenjun , Eaton Charles B. , LaCroix Andrea Z. 
Published: October 2017

ObjectiveTo investigate associations of body mass index (BMI), waist circumference (WC), and waist/hip ratio (WHR) with survival to age 85 years with mobility limitation or death before age 85 years among older women with total knee replacement (TKR) or total hip replacement (THR) for osteoarthritis (OA).MethodsThis was a prospective study of women (ages 65–79 years at baseline) from the Women's Health Initiative, recruited during 1993–1998 and followed through 2012. Women's Health Initiative data were linked to Medicare claims data to determine TKR (n = 1,867) and THR (n = 944) for OA. Women were followed for up to 18 years after undergoing THR or TKR to determine mobility status at age 85 years.ResultsCompared with normal‐weight women, overweight, obese I, and obese II women with THR had significantly increased risk of survival to age 85 years with mobility limitation (P < 0.001 for linear trend), with the strongest risk among obese II women (odds ratio [OR] 4.37 [95% confidence interval (95% CI) 1.96–9.74]). Obese II women with THR also had increased risk of death before age 85 years. Women with THR and WC >88 cm relative to ≤88 cm had increased risk of survival to age 85 years with mobility limitation (OR 1.65 [95% CI 1.17–2.33]) but not death before age 85 years. High BMI, WC, and WHR were associated with significantly increased risk of late‐life mobility limitation and death among women with TKR for OA.ConclusionAmong older women who underwent THR or TKR for OA, baseline general and abdominal obesity were associated with increased risk of late‐life mobility limitation.
Generalized maximum correntropy detector for non‐Gaussian environments
Authors: Hakimi Saeed , Abed Hodtani Ghosheh 
Published: October 2017

SummaryThis paper addresses the problem of multiple‐hypothesis detection. In many applications, assuming the Gaussian distribution for undesirable disturbances does not yield a sufficient model. On the other hand, under the non‐Gaussian noise/interference assumption, the optimal detector will be impractically complex. Therewith, inspired by the optimal maximum likelihood detector, a suboptimal detector is designed. In particular, a novel detector based on the generalized correntropy, which adopts the generalized Gaussian density function as the kernel, is proposed. Simulations demonstrate that, in non‐Gaussian noise models, the generalized correntropy detector significantly outperforms other commonly used detectors. The efficient and robust performance of the proposed detection method is illustrated in both light‐tailed and heavy‐tailed noise distributions.
Protein Biophosphors: Biodegradable, Multifunctional, Protein‐Based Hydrogel for White Emission, Sensing, and pH Detection
Authors: Benson Kyle , Ghimire Ananta , Pattammattel Ajith , Kumar Challa V. 
Published: October 2017

AbstractA highly efficient, multifunctional, bioderived white‐emitting hydrogel (biophosphor) consisting of crosslinked bovine serum albumin and three fluorescent dyes, Coumarin 460, fluorescein, and 5(6)‐carboxy‐x‐rhodamine, is reported here. White emission is obtained upon excitation of the biophosphor at 365 nm with appropriate mole ratios of the above dyes. The CIE 1931 chromaticity coordinates of white emission with 365 nm excitation are (0.36, 0.37), and the correlated color temperature is 5300 K. Multifunctional nature of the biophosphor is also demonstrated. A UV‐light‐emitting‐diode (361 nm) coated with this biophosphor, for example, indicates white emission (CIE 0.28, 0.31) with a half‐life of 106 (±5) h. The white emission is also highly sensitive to pH over a broad range (pH 1–11). Incorporation of glucose oxidase and peroxidase in the biophosphor allows for the detection of glucose over a physiologically relevant range of 1.8–288 mg dL−1. This is a unique, advanced biophosphor with LED and sensing applications, and it is the first example of a multifunctional, proteinaceous white emitter.
Current paradigms in the management of Philadelphia chromosome positive acute lymphoblastic leukemia in adults
Authors: El Fakih Riad , Jabbour Elias , Ravandi Farhad , Hassanein Mona , Anjum Farhan , Ahmed Syed , Kantarjian Hagop 
Published: October 2017

AbstractPhiladelphia chromosome‐positive (Ph‐positive) acute lymphoblastic leukemia (ALL) is a biologically, clinically, and genetically distinct subtype of precursor‐B ALL. The Ph chromosome, results from a reciprocal translocation of the ABL1 kinase gene on chromosome 9 to the breakpoint cluster region (BCR) gene on chromosome 22. Depending on the translocation breakpoint, typically a p210 BCR‐ABL1 or a p190 BCR‐ABL onc protein are generated; both are constitutively active tyrosine kinases that play a central role to alter signaling pathways of cell proliferation, survival, and self‐renewal, leading to leukemogenesis. In Ph‐positive ALL, the p190‐BCR‐ABL (minor [m]‐bcr) subtype is more frequent than the p210‐BCR‐ABL (major [M]‐bcr) subtype, commonly found in chronic myeloid leukemia. The Philadelphia chromosome is the most frequent recurrent cytogenetic abnormality in elderly patients with ALL. Its incidence increases with age, reaching ∼50% in patients with ALL aged 60 years and over. Patients traditionally had a very poor outcome with chemotherapy, particularly if they do not undergo allogeneic hematopoietic cell transplantation (allo‐HCT) in first complete remission (CR1). With the availability of multiple tyrosine kinase inhibitors (TKI), the therapeutic armamentarium is expanding quickly. However, there is no consensus on how to best treat Ph‐positive ALL. With modern therapy, improved outcomes have led to the emergence of a number of controversies, including the need for intensive chemotherapy, the ideal TKI, and whether all eligible patients should receive an allo‐HSCT, and if so, what type. Here, we discuss these controversies in light of the available literature.
Relatively favorable outcome after allogeneic stem cell transplantation for BCR‐ABL1‐positive AML: A survey from the acute leukemia working party of the European Society for blood and marrow transplantation (EBMT)
Authors: Lazarevic Vladimir Lj , Labopin Myriam , Depei Wu , Yakoub‐Agha Ibrahim , Huynh Anne , Ljungman Per , Schaap Nicolaas , Cornelissen Jan J. , Maillard Natacha , Pioltelli Pietro , Gedde‐Dahl Tobias , Lenhoff Stig , Houhou Mohamed , Esteve Jordi , Mohty Mohamad , Nagler Arnon 
Published: October 2017

AbstractThe aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR‐ABL1‐positive acute myeloid leukemia (AML). Fifty‐seven patients (median age, 48 years, range: 19‐67) with BCR‐ABL1 positive AML undergoing SCT were identified. The majority of the patients (70%) received a TKI before the transplant. At SCT 48 patients were in CR (45 in CR1), while 9 patients were transplanted in a more advanced stage of the disease. MRD was negative (BCR‐ABL1/ABL < 104) at time of SCT in 36.1% (14/40). After SCT, 16 (61.5%) out of 26 patients with MRD positive at transplantation reached MRD negativity. After a median follow‐up of 6.3 years (0.7–14.2), NRM, RI, LFS, OS, and GRFS at 5 years were 18.1%, 37%, 44.2%, 53.8%, and 32.1%, respectively. The cumulative incidence of acute GvHD grade II‐IV was 16.4%, incidence of chronic GvHD 24.9%, and of extensive cGvHD 21.4%, respectively. In patients who received SCT in CR1, 5‐yr NRM, RI, LFS, OS, and GRFS were 15.9%, 36.4%, 46.5%, 59.4%, and 34.9%, respectively. Univariate analysis showed that age (<50 vs. ≥50 years) was associated with RI (5‐yr: 22.7 vs. 50%), LFS (5‐yr: 61.9 vs. 31.8%), and GRFS (5‐yr: 52.4 vs. 18.2%), whereas MRD‐negative status before SCT was associated with an improved GRFS (38.9 vs. 16.7%). We conclude that the outcome of patients <50 years of age with BCR‐ABL1‐positive AML receiving allogeneic SCT in CR is relatively favorable, possibly reflecting the beneficial effect of the use of TKI.
Hereditary stomatocytosis: An underdiagnosed condition
Authors: Andolfo Immacolata , Russo Roberta , Gambale Antonella , Iolascon Achille 
Published: October 2017

AbstractHereditary stomatocytoses are a wide class of hemolytic anemias characterized by alterations of ionic flux with increased cation permeability that results in inappropriate shrinkage or swelling of the erythrocytes, and water lost or gained osmotically. The last few years have been crucial for new acquisitions in this field in terms of identifying new causative genes and of studying their pathogenetic mechanisms. This review summarizes the main features of erythrocyte membrane transport diseases, dividing them into forms with either isolated erythroid phenotype (nonsyndromic) or extra‐hematological manifestations (syndromic), and focusing particularly on the most recent advances regarding dehydrated forms of hereditary stomatocytosis and familial pseudohyperkalemia.
A CuII‐based Metal–Organic Framework as an Efficient Photocatalyst for Direct Hydroxylation of Benzene to Phenol in Aqueous Solution
Authors: Zhang Li , Qiu Shuhai , Jiang Guoqing , Jiang Guomin , Tang Ruiren 
Published: October 2017

AbstractA CuII‐based metal–organic framework (MOF; 1), constructed with imidazole carboxylate ligands (5‐(1 H‐imidazol‐1‐yl)isophthalic acid) and copper(II) ions was prepared and characterized in detail by XRD, Brunauer–Emmett–Teller (BET), thermogravimetric analysis (TGA), and IR methods. Its catalytic performance for the direct hydroxylation of benzene to phenol has been investigated. A benzene conversion of 29 % as well as a high phenol selectivity above 95 % has been obtained at 60 °C in water. The cycling tests showed no significant decrease after five runs, indicating good stability and reuse properties of the CuII‐based MOF (1). The effect of adding the hydroxyl radical scavenger, thiourea, and the ESR spectra of the catalytic system have confirmed the existence of hydroxyl radicals, which indicates the catalytic mechanism follows a Fenton‐type route. This economically and environmentally friendly approach with CuII‐based MOFs is expected to find applications in the hydroxylation of aromatics.
Development of the Japanese version of the Cornell Assessment of Pediatric Delirium
Authors: Hoshino Haruhiko , Matsuishi Yujiro , Shimojo Nobutake , Enomoto Yuki , Kido Takahiro , Inoue Yoshiaki 
Published: October 2017

AimDelirium is a form of acute cerebral dysfunction and is associated with increased length of hospital stay, mortality, and health‐care costs for adult patients in intensive care. However, in Japan, there are currently no reliable criteria or tools for diagnosing delirium in critically ill pediatric patients. The purpose of this study was to translate the Cornell Assessment of Pediatric Delirium (CAPD)—a screening tool for pediatric delirium—from English to Japanese for use in the diagnosis of delirium for pediatric patients in pediatric intensive care units.MethodsThe back‐translation method was used to ensure equivalence in the Japanese version of the CAPD and its accompanying developmental anchor points. The translation process was repeated by a multidisciplinary committee of medical researchers and clinicians.ResultsThe final back‐translated version of the CAPD was submitted to the original author, who gave her approval.ConclusionThe Japanese CAPD was developed and its effectiveness tested using a standardized procedure. Further study is required to test the validity and reliability of the Japanese version of the CAPD.
Peptide Logic Circuits Based on Chemoenzymatic Ligation for Programmable Cell Apoptosis
Authors: Li Yong , Sun Sujuan , Fan Lin , Hu Shanfang , Huang Yan , Zhang Ke , Nie Zhou , Yao Shouzhou 
Published: October 2017

AbstractA novel and versatile peptide‐based bio‐logic system capable of regulating cell function is developed using sortase A (SrtA), a peptide ligation enzyme, as a generic processor. By modular peptide design, we demonstrate that mammalian cells apoptosis can be programmed by peptide‐based logic operations, including binary and combination gates (AND, INHIBIT, OR, and AND‐INHIBIT), and a complex sequential logic circuit (multi‐input keypad lock). Moreover, a proof‐of‐concept peptide regulatory circuit was developed to analyze the expression profile of cell‐secreted protein biomarkers and trigger cancer‐cell‐specific apoptosis.