bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of cropping pattern and green manure on the antagonistic potential and the diversity of egg pathogenic fungi in fields with Heterodera schachtii infection
Authors: Pyrowolakis Aris , Schuster Ralf-Peter , Sikora Richard 
Published: July 2002

AbstractThe potential of egg pathogenic fungi in soil from two different sites infested with Heterodera schachtii was measured with a new method in pot experiments. The potential proved to be much greater in the rotation field (sugar beet-wheat) than in the monoculture field (mangold). The green manuring with three different intercrops reduced the potential in soil from the rotation field and promoted it in the monoculture field. Investigation on the diversity of egg pathogens in the two fields showed that the monoculture field had a greater diversity than the rotation field. A large fungal diversity is thought to act as a buffer against microbial changes. This is probably a reason why green manuring in the monoculture field did not reduce this fungal diversity as markedly as in the rotation field and why it did not reduce the potential of egg pathogenic fungi in the same field. Effets du type de rotation et d'engrais vert sur le potentiel antagoniste etla diversite des champignons pathogenes des oeufs du nematode a kyste de la betterave Heterodera schachtii - Le potentiel antagoniste de champignons pathogenes des oeufs dans le sol de deux champs differents infestes par Heterodera schachtii a ete evalue a l'aide d'une nouvelle methode lors d'une experimentation en pots. Ce potentiel est apparu plus important dans la rotation (betterave a sucre-ble) que dans la monoculture (betterave fourragere). L'apport d'engrais vert a l'occasion de trois cultures intercalaires a diminue le potentiel dans le sol sous rotation et l'a accru en monoculture. L'etude de la diversite des champignons pathogenes d'oeufs dans les deux champs a montre une plus grande diversite en monoculture que sous rotation. Une large diversite des champignons est consideree comme un tampon vis-a-vis des changements bacteriens. Ceci explique probablement pourquoi l'apport d'engrais vert en monoculture n'a pas reduit cette diversite fongique autant que dans la rotation et pourquoi cet apport n'a pas diminue le potentiel des champignons pathogenes d'oeufs dans le meme champ.
The genus Tylencholaimellus Cobb in M. V. Cobb, 1915 (Nematoda: Dorylaimida): general morphology, taxonomy, compendium, and polytomous key to the species
Authors: Reyes Peña Santiago , Peralta Manuel 
Published: July 2002

Abstract
A general study of the morphology, evolutionary trends and intrageneric
taxonomy of the genus Tylencholaimellus Cobb in M. V. Cobb, 1915 is
presented. Variability of its main morphological features is described and
illustrated, and their possible evolutionary trends are discussed. The
subgenera Tylencholaimellus (Tylencholaimellus) Cobb in M. V. Cobb, 1915 and
Tylencholaimellus (Coronatylencholaimellus) Jairajpuri & Ahmad, 1992 are
considered synonyms, and consequently not retained. A diagnosis of the
genus, a list of its species and a polytomous key to the species are given.
Le genre Tylencholaimellus Cobb in M. V. Cobb, 1915 (Nematoda: Dorylaimida):
morphologie generale, taxonomie, compendium et clef polytomique des especes
- Une etude generale de la morphologie, des tendances evolutives et de la
taxonomie intragenerique du genre Tylencholaimellus Cobb in M. V. Cobb, 1915
est presentee. La variabilite de principales caracteristiques morphologiques
du genre est decrite et illustree et leurs tendances evolutives possibles
sont discutees. Les sous-genres Tylencholaimellus (Tylencholaimellus) Cobb
in M. V. Cobb, 1915 et Tylencholaimellus (Coronatylencholaimellus)
Jairajpuri & Ahmad, 1992 sont consideres comme synonymes et en
consequence non conserves. Une diagnose du genre ainsi qu'une liste et une
clef polytomique de ses especes sont donnees.
Attachment of endospores of Pasteuria penetrans to males and juveniles of Meloidogyne spp.
Authors: Carneiro Regina M.D.G. , Randig Onivaldo , Freitas Leandro G. , Dickson Don W. 
Published: July 2002

Abstract
The attachment of endospores to Meloidogyne spp. males and second stage
juveniles (J2) was evaluated in two different in vitro assays of seven
isolates of Pasteuria penetrans from Florida, USA. In the first assay,
endospores of all seven isolates adhered to J2 but not males of M. arenaria
race 1. In the second assay, two isolates differed in the specificity of
spore attachment to J2 of six Meloidogyne spp. Isolate B4, from Pratylenchus
scribneri, showed a similar degree of attachment to J2 of M. arenaria race
2, M. javanica (two populations) and to M. incognita race 3, but did not
attach to males of seven species. Isolate P100, from Meloidogyne sp., had
high rates of attachment to M. javanica from Rio Grande do Sul State and to
M. paranaensis, but lower rates to M. arenaria and M. javanica from Parana
State. These data indicate that attachment ability depends not only on the
Meloidogyne species but also on the particular population of a species. The
high rate of attachment to male but not J2 M. hapla indicates that endospore
attachment may also depend upon nematode stage, species, race and population
and on Pasteuria isolate. Germinated endospores attached to male M. hapla
were examined by scanning electron microscopy but few had successfully
penetrated the cuticle. Adhesion des endospores de Pasteuria penetrans aux
males et juveniles de Meloidogyne spp. - L'adhesion des spores de Pasteuria
penetrans aux males et juveniles de deuxieme stade (J2) de Meloidogyne spp.
a ete evaluee lors de deux differents tests in vitro comprenant sept isolats
de P. penetrans provenant de Floride, USA. Lors du premier test les
endospores des sept isolats ont adhere aux J2 mais non aux males de M.
arenaria race 1. Lors du second test deux isolats se sont distingues quant a
la specificite de l'adhesion de leurs spores aux J2 de six des especes de
Meloidogyne. L'isolat B4, provenant de Pratylenchus scribneri, montre un
taux d'adhesion similaire vis-a-vis des J2 de M. arenaria race 2, M.
javanica (deux populations) et M. incognita race 3, mais n'adhere aux males
d'aucune des sept especes. L'isolat P 100, provenant de Meloidogyne sp.,
Montre un taux d'adhesion eleve vis-a-vis tant de M. javanica provenant de
l'Etat de Rio Grande del Sul que de M. paranensis mais ce taux est faible
vis-a-vis de M. arenaria et M. javanica originaires de l'Etat du Parana. Ces
donnees indiquent que la faculte d'adhesion depend non seulement de l'espece
de Meloidogyne en cause mais egalement de la population particuliere de
cette espece. Le taux eleve d'adhesion vis-a-vis des males, mais non des J2,
de M. hapla indique que cette adhesion peut dependre du stade de
developpement du nematode, de son espece, race ou population ainsi que de
l'isolat lui-meme de P. penetrans. Les endospores fixees aux males de M.
hapla, et ayant germe, ont ete examinees en microscopie electronique a
balayage: peu d'entre elles avaient reussi a traverser la cuticule.
In situ high temperature single crystal X-ray diffraction study of a natural omphacite
Authors: Pavese A. , Bocchio R. , Ivaldi G. 
Published: July 2002

AbstractIn situ high temperature single crystal X-ray diffraction (XRD) experiments have been performed on a chemically quasi-ideal omphacite sample up to 1000°C. The lattice parameters were studied as a function of temperature, and their thermal expansion coefficients determined. The b and c cell edges show discontinuities as a function of temperature which are interpreted here in terms of intracrystalline cation diffusion processes. Structure refinements have been carried out using data collected at room temperature, at 800°C and at ambient conditions after cooling. The structural behaviour as a function of temperature of chemically quasi-ideal omphacites is compared with those of jadeite and diopside.
The chemical composition of uraninite in Variscan granites of the Erzgebirge, Germany
Authors: Förster H.-J. 
Published: July 2002

AbstractUraninite is widespread as an accessory mineral in the Erzgebirge granites. It occurs throughout the entire comagmatic series of strongly peraluminous S-type Li-mica granites and has been discovered in more evolved transitional I-S type biotite and two-mica granites, but is rare in those of A-type affinity. Textural relationships and chemical ages imply that uraninite is of magmatic origin. Its composition is variable with a proportion of U plus radiogenic Pb between 71 and 99 mol.%. Uraninite has incorporated Th, Y, and the REE in total amounts between 1 and 29 mol.%. Elements such as P, Si, Al, Ca, and Fe are subordinate. Uraninite from two-mica and Li-mica granites is low in ThO2 (0.8–6.5 wt.%), Y2O3 (0–0.8 wt.%) and REE2O3 (0.1–0.6 wt.%). In contrast, biotite granites from the Kirchberg pluton contain uraninite which is enriched in these components (in wt.%) (ThO2 = 5.6–11.0, Y2O3 = 0.6–5.5, Ce2O3 = 0.1–0.6, Dy2O3 = 0.2–1.1). Commonly, the lanthanide and actinide contents in uraninite correlate poorly with those in the host granite. In S-type Li-mica granites as well as fractionated two-mica and biotite granites, uraninite is the dominant contributor to the bulk-rock U content. Here the proportion of U approaches 80–90%.
Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura
Authors: Emilia Giovanni , Longo Giuseppe , Luppi Mario , Gandini Giovanna , Morselli Monica , Ferrara Leonardo , Amarri Sergio , Cagossi Katia , Torelli Giuseppe 
Published: July 2002

Abstract
Recent reports have suggested an association betweenHelicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pyloriinfection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 × 109/L-120 × 109/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pyloriinfection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients.
The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
Authors: Li Zhihua , Zhu Yuan Xiao , Plowright Elizabeth E. , Bergsagel P. Leif , Chesi Marta , Patterson Bruce , Hawley Teresa S. , Hawley Robert G. , Stewart A. Keith 
Published: July 2002

AbstractTranslocations involving fibroblast growth factor receptor 3 (fgfr3) have been identified in about 25% of patients with myeloma. To directly examine the oncogenic potential offgfr3, murine bone marrow (BM) cells were transduced with retroviral vectors containing either wild-type fgfr3 or an activated mutant form of the receptor, fgfr3-TD. Mice transplanted with FGFR3-TD–expressing BM developed a marked leukocytosis and lethal hematopoietic cell infiltration of multiple tissues within 6 weeks of transplantation. Secondary and tertiary recipients of spleen or BM from primary fgfr3-TD mice also developed tumors within 6 to 8 weeks. Analysis of the circulating tumor cells revealed a pre-B-cell phenotype in most mice, although immature T-lymphoid or mature myeloid populations also predominated in some animals. Enhanced lymphoid but not myeloid colony formation was observed in the early posttransplantation period and only interleukin 7 and FGF-responsive pre-B-cell lines could be established from tumors. Cell expansions in primary recipients appeared polyclonal, whereas tumors in later passages exhibited either clonal B- or T-cell receptor gene rearrangements. Mice transplanted with wild-type FGFR3-expressing BM developed delayed pro-B-cell lymphoma/leukemias approximately 1 year after transplantation. These studies confirm that FGFR3 is transforming and can produce lymphoid malignancies in mice.
Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome
Authors: Yokoo Takashi , Ohashi Toya , Utsunomiya Yasunori , Shen Jin Song , Hisada Yutaka , Eto Yoshikatsu , Kawamura Tetsuya , Hosoya Tatsuo 
Published: July 2002

AbstractIn chronic inflammation, macrophages and neutrophils, which are derived from bone marrow, play a pivotal role. Therefore, reconstitution of bone marrow with anti-inflammatory stem cells may modify inflammation. In this study, transplantation-based gene therapy was applied to glomerular inflammation for a long-lasting suppression of the glomerular damage seen in chronic nephritis. Bone marrow cells were harvested from male donor mice, which had received 5-fluorouracil 3 days previously, and transduced with an interleukin 1 (IL-1) receptor antagonist (IL-1Ra) or a mock gene using a retrovirus vector. After confirmation that transduced cells possessed the transgene at approximately 0.7 copies per cell and secreted recombinant IL-1Ra, these cells were infused into sublethally irradiated (6 Gy) female recipients once daily for 4 consecutive days. These female recipient mice had the male Y antigen in bone marrow, liver, and spleen, and 10% to 20% of their spleen cells possessed the transgene even 8 weeks after transplantation. Glomerulonephritis was then induced in these mice. Renal function and histology were retarded in the mice whose bone marrow was reconstituted with IL-1Ra–producing cells compared with mock transduced cells. In situ hybridization using a Y painting probe revealed that transplanted donor cells were recruited into the glomerulus upon induction of nephritis, suggesting therapeutic effects were channeled through the secretion of IL-1Ra from these cells. Furthermore, the survival rate after a second challenge with nephrotoxic antibody was significantly improved in the IL-1Ra chimera. These results suggest that reconstitution of bone marrow for continuous supply of anti-inflammatory cells may be a useful strategy for the treatment of chronic inflammation.
Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma
Authors: Martinez-Climent Jose A. , Vizcarra Esperanza , Sanchez Dolors , Blesa David , Marugan Isabel , Benet Isabel , Sole Françesc , Rubio-Moscardo Francisca , Terol Maria J. , Climent Joan , Sarsotti Elena , Tormo Mar , Andreu Enrique , Salido Marta , Ruiz Maria A. , Prosper Felipe , Siebert Reiner , Dyer Martin J. S. , Garcı́a-Conde Javier 
Published: July 2002

Abstract
Patients with mantle cell lymphoma (MCL) may present with either nodal or leukemic disease. The molecular determinants underlying this different biologic behavior are not known. This study compared the pattern of genetic abnormalities in patients with nodal and leukemic phases of MCL using comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) for specific gene loci. Although both leukemic and nodal MCL showed similar genomic patterns of losses (involving 6q, 11q22-q23, 13q14, and 17p13) and gains (affecting 3q and 8q), genomic loss of chromosome 8p occurred more frequently in patients with leukemic disease (79% versus 11%,P &lt; .001). Subsequent CGH analysis confirmed the genomic loss of 8p21-p23 in 6 of 8 MCL cell lines. Interestingly,MYC gene amplification was restricted to cases with 8p deletion. These data indicate the presence of a novel tumor suppressor gene locus on 8p, whose deletion may be associated with leukemic dissemination and poor prognosis in patients with MCL.
X-linked thrombocytopenia caused by a novel mutation ofGATA-1
Authors: Mehaffey Michele G. , Newton Anthea L. , Gandhi Manish J. , Crossley Merlin , Drachman Jonathan G. 
Published: July 2002

AbstractA family with recessive X-linked thrombocytopenia affecting 4 males in 2 generations, characterized by macrothrombocytopenia, profound bleeding, and mild dyserythropoiesis, is described. Microsatellite linkage analysis identified a region of the X chromosome including theGATA-1 gene, which encodes a critical transcription factor involved in erythrocyte and megakaryocyte development. By sequencing the entire coding region of GATA-1, a 2-base mutation was detected that results in a single amino acid substitution (glycine 208 to serine) within a highly conserved portion of the N-terminal zinc finger domain. Restriction fragment length polymorphism confirmed that this novel mutation segregated with the affected males and female carrier. Although not required for DNA binding, Gly208 of GATA-1 is involved in direct interaction with Friend of GATA-1 (FOG), a cofactor required for normal megakaryocytic and erythroid development. These results demonstrate that the GATA-1–FOG interaction is partially disrupted by the mutation and that the greatest effect involves contact with the FOG zinc finger 9. These findings help describe a novel mutation of GATA-1 in humans as a cause of X-linked thrombocytopenia, and they confirm the vital role played by this transcription factor during in vivo megakaryocyte development.
Severe coagulation factor V deficiency caused by 2 novel frameshift mutations: 2952delT in exon 13 and 5493insG in exon 16 of factor 5 gene
Authors: Ajzner Éva , Balogh István , Szabó Teréz , Marosi Anikó , Haramura Gizella , Muszbek László 
Published: July 2002

AbstractA male infant with severe bleeding tendency had undetectable factor V activity. Sequence analysis of the proband's DNA revealed one base deletion in exon 13 (2952delT) and one base insertion in exon 16 (5493insG) in heterozygous form. Both mutations introduced a frameshift and a premature stop at codons 930 and 1776, respectively. The proband's father and mother were heterozygous for 2952delT and for 5493insG, respectively. Both mutations would result in the synthesis of truncated proteins lacking complete light chain or its C-terminal part. In the patient's plasma, no factor V light chain was detected by enzyme-linked immunosorbent assay. The N-terminal portion of factor V containing the heavy chain, and the connecting B domain was severely reduced but detectable (1.7%). A small amount of truncated factor V–specific protein with a molecular weight ratio of 236 kd could be immunoprecipitated from the plasma and detected by Western blotting. This protein, factor VDebrecen, corresponds to the translated product of exon 16 mutant allele.
Leukemia Cell Hitchhiking Hypoxia Responsive Nanogel for Improved Immunotherapy of Acute Myeloid Leukemia
Authors: Chen Haoting , Wang Dongyao , Yao Yuying , Xiao Yafang , Zhao Zhuangzhuang , Zhang Ziqi , Liu Shaoyu , Wang Xinlu , Yang Shiying , Huang Panpan , Zhou Zijian , Zhu Xiaoyu , Guo Weisheng 
Published: September 2024

AbstractImmune checkpoint blockade (ICB) with anti‐CD47 antibodies (aCD47) is a promising therapeutic approach that has the potential to revolutionize the treatment of acute myeloid leukemia (AML). However, the low immune response rate and high systemic hematotoxicity remain substantial barriers to its success in clinical AML treatment. A synthetic protein nanogel formulation of aCD47 and resiquimod (R848) (termed CR‐TNG) is developed that targets TIM‐3 on the surface of leukemia cells. Upon intravenous injection, the CR‐TNG efficiently conjugates onto the blood‐circulating leukemia cells and migrates toward the bone marrow (BM) by exploiting the natural BM homing capability of leukemia cells. CR‐TNG releases aCD47 and R848 in a bone marrow hypoxic microenvironment, which significantly induces immunosuppression and enhances the anti‐leukemia immune response by activating macrophage “eat me” signaling and priming myeloid macrophages in the BM niche. These findings provide a leukemia cell‐hitchhiking drug delivery strategy that addresses both systemic hematotoxicity and low immune response rate in AML.
A Novel Method for Increasing Phase‐Change Microcapsules in Nanofiber Textile through Electrospinning
Authors: Gu Bin , Li Guo , Zhang Qiang , Pan Haodan , Duan Mengfan , Weng Liqing , Zhao Dongliang 
Published: September 2024

AbstractPhase‐change textiles can achieve temperature regulation in variable ambient environments, however, augmenting the amounts of phase‐change materials (PCMs) in textiles remains a significant challenge due to the occurrence of leakage with higher amounts. Herein, a novel approach is proposed for the fabrication of a hierarchical nanofiber textile embedded with a substantial quantity of phase‐change microcapsules (PCMC) using electrospinning. Such nanofiber textile is composed of a polyvinylidene fluoride‐hexafluoropropylene fibers (PVDF‐HFP) layer and a polyvinyl butyral fibers doped with 60 wt% of PCMC (PVB/PCMC‐60) layer. Gratifyingly, doped PCMC shows no signs of rupture and exhibits excellent cycling stability. Furthermore, the incorporation of the PCMC does not affect the spectral characteristics of the PVDF‐HFP layer while providing a substantial enthalpy of fusion (92.6 J g−1) to the PVB/PCMC‐60 layer. This serves to compensate for the deficiency in radiative cooling capacity and effectively mitigates temperature fluctuations and overheating of the textile. Outdoor test results indicate that the nanofiber textile can achieve temperature drops of 3.7 and 14.8 °C compared to textile without the PCMC (namely PVDF‐HFP/PVB) and cotton, and attains a subambient temperature drop of 6.5 °C. Additionally, the nanofiber textile exhibits desirable mechanical strength, flexibility, washability, breathability, moisture permeability, and sun protection.
Divergent Synthesis of (CF3)‐Indazolo[3,2‐a]Isoquinolines with Potent Photophysical Property and Anticancer Activity from 3‐Aryl‐1H‐Indazoles and Sulfoxonium Ylides
Authors: Zhou Qianting , Yan Shengnan , Ma Chunhua , Gong Yi‐Jun , Zhang Xinying , Fan Xuesen 
Published: September 2024

AbstractTransition‐metal‐catalyzed inert C−H bond functionalization using sulfoxonium ylides as metal carbene surrogates to replace the explosive and labile diazo compounds is synthetically attractive. Presented herein is a divergent synthesis of (CF3)‐indazolo[3,2‐a]isoquinoline derivatives based on C−H bond activation‐initiated cascade reactions of 3‐aryl‐1H‐indazoles with sulfoxonium ylides. The formation of products involves Rh(III)‐catalyzed C(sp2)−H bond metalation, carbene formation, migratory insertion, proto‐demetalation and intramolecular condensation. In general, this newly developed protocol features simple substrates, structurally diverse products, step‐economy and scalability. In addition, evaluation of the photophysical properties and anti‐proliferative activity against three human cancer cell lines of the products thus obtained showed that some of them possess potent anticancer activity with potential self‐tracking capability through fluorescence detection.
Obtaining a Practical Wearable Supercapacitor Power Supply
Authors: Inman Alex , Parker Tetiana , Zhang Yuan , Saraf Mohit , Gogotsi Yury 
Published: September 2024

AbstractDue to the ubiquity of textiles in the lives, electronic textiles (E‐textiles) have emerged as a future technology capable of addressing a myriad of challenges from mixed reality interfaces, on‐garment climate control, patient diagnostics, and interactive athletic wear. However, providing sufficient electrical power in a textile form factor has remained elusive. To address this issue, different approaches are discussed, starting with supercapacitors' advantages and limitations and material choices for textile‐based supercapacitors before discussing proper data analysis and design considerations of textile‐based energy storage to power wearable electronics.