bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Affordable Care Act, Substance Use Disorders, and Low-Income Clients: Implications for Social Work
Authors: McCabe Heather A. , Wahler Elizabeth A. 
Published: April 2016

Abstract
Social workers are leaders in the substance abuse services field and may often work in substance use disorder (SUD) education, prevention, assessment, treatment, or resource coordination and case management roles. As the Patient Protection and Affordable Care Act (ACA) (2010) drives changes in the fields of health and behavioral health, social workers have an opportunity to lead structural changes at the micro and macro levels that will have a positive impact on low-income clients with SUDs. In this article, authors examine the current state of SUDs and health care access, the impact of the ACA on the field, and implications for social work practice and education. Social workers should seek specialized education and credentialing in SUD services, know how to help clients apply for health care coverage, and advocate for integrated substance abuse treatment and health care programs and an expansion of Medicaid in their local communities. Social workers are well positioned to be a voice for clients to ensure that the current structural changes result in a better, integrated system of care that is able to respond to the needs of low-income clients with SUDs.
Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies
Authors: Sibaud Vincent , Meyer Nicolas , Lamant Laurence , Vigarios Emmanuelle , Mazieres Julien , Delord Jean Pierre 
Published: April 2016

Purpose of review
The therapeutic use of anti-PD-1/PD-L1 antibodies (nivolumab, pembrolizumab) is rapidly increasing. Given their mechanism of action that triggers T-cell activation, these immune checkpoint inhibitors induce specific adverse events that are mostly of immunologic origin. In this way, cutaneous toxicities represent the most frequent immune-related adverse events (irAEs). The purpose of this review is to summarize the most prevalent dermatologic complications induced by PD-1/PD-L1 immune checkpoint-blocking antibodies and to compare their dermatologic safety profile with anti-CTLA-4 ipilimumab.

Recent findings
More than 40% of melanoma patients treated with anti-PD-1 therapy are faced with dermatologic irAEs. However, these cutaneous complications usually remain self-limiting and readily manageable. Nonspecific macular papular rash and pruritus represent the most common manifestations. More characteristic lichenoid dermatitis or psoriasis may also develop. Vitiligo is also frequent in patients with melanoma but has not been reported in other types of solid cancers. Mucosal involvement may also occur, including xerostomia and lichenoid reactions. Although available data remain scarce, anti-PD-L1 antibodies present a similar dermatologic safety profile.

Summary
Dermatologic irAEs induced by PD-1 or PD-L1 blockade therapy rarely result in significant morbidity or permanent discontinuation of treatment. However, early recognition and appropriate management are crucial for restricting dose-limiting toxicities.
Ocular and orbital side-effects of checkpoint inhibitors: a review article
Authors: Antoun Joëlle , Titah Cherif , Cochereau Isabelle 
Published: April 2016

Purpose of review
Checkpoint inhibitors have been increasingly considered as new targets for cancer therapies. Patients receiving checkpoint inhibitors develop many immune-related adverse events (IRAEs). However, ophthalmic IRAEs are rare and have been reported in less than 1% of patients. To date, few case reports evaluating the ophthalmological side-effects of checkpoint inhibitors have been published. In this review, we plan to report the different ocular and orbital side-effects of the checkpoint inhibitors, and to help guide ophthalmologists and oncologists in their management.

Recent findings
Ocular side-effects of checkpoint inhibitors include peripheral ulcerative keratitis, uveitis, Vogt–Koyanagi–Harada syndrome, choroidal neovascularization and melanoma-associated retinopathy. Both thyroid-associated orbitopathy and idiopathic orbital inflammation have also been reported in association with checkpoint inhibitors. Mild IRAE can be treated with topical steroids, whereas systemic corticosteroids and discontinuation of checkpoint inhibitors are indicated in more severe ocular and orbital inflammation.

Summary
Physicians involved in the care of oncologic patients should be aware of the ocular and orbital IRAEs that may develop with checkpoint inhibitors. A strong cooperation between oncologists and ophthalmologists is required in the diagnosis and prompt management of these IRAEs.
Present and future role of surgery in metastatic gastrointestinal malignancies
Authors: Naredi Peter , Olofsson Bagge Roger 
Published: April 2016

Purpose of review
Metastases from gastrointestinal malignancies are systemic or abdominal disseminations of cancer cells. From a biological perspective surgical resections are questionable but case series show that for some tumour types, surgery influences survival outcome. This review focuses on management and indications for surgery in recent literature of these metastatic gastrointestinal malignancies.

Recent findings
A few gastrointestinal malignancies have emerged to be candidates for surgery in case of metastatic disease. Surgery can be considered in selected cases with liver metastases or abdominal dissemination of colorectal cancer, metastases from gastrointestinal stromal tumours or neuroendocrine tumours. On the contrary, recent publications do not support surgery for metastatic disease of any other gastrointestinal origin. The literature has ample examples of small series and anecdotal cases of successful surgical interventions for most tumour types but no new evidence has been presented to support broader indications for surgery.

Summary
The evidence base for surgery of different metastatic gastrointestinal malignancies is unchanged. There are some clarifications when to perform surgery and the timing of surgery in regard to combined treatments. No new tumour types are added to potential candidates for surgery.
Effect of Breakfast on the Exposure of the Once-Daily Tacrolimus Formulation in Stable Kidney Transplant Recipients
Authors: Stifft Frank , Undre Nasrullah , van Hooff Johannes P. , Christiaans Maarten H. L. 
Published: April 2016

Background:
The once-daily Tacrolimus formulation (Tac ONCE-DAILY) has to be taken on an empty stomach. This is inconvenient for patients and may hamper compliance. The influence of food intake on the exposure of Tac ONCE-DAILY is unknown in transplant recipients. We compared the pharmacokinetics (PKs) of Tac ONCE-DAILY in stable kidney transplant recipients under fasted and fed conditions.

Methods:
In an open-label, single-center, cross-over PK study, 27 stable kidney white transplant recipients (17 male, 10 female) treated with Tac ONCE-DAILY under fasted conditions were enrolled. Two 10-point 24-hour blood concentration time profiles [area under the blood concentration time curve from time 0 to 24 hours (AUC0–24)] were collected under steady state conditions. The primary objective was to investigate the effect of food on the PKs and relative bioavailability of Tac ONCE-DAILY.

Results:
Twenty-seven stable renal transplant patients provided 1 AUC0–24 under fasted and fed conditions, respectively. AUC0–24, C24, and Cmax, were lower in the fed state and Tmax was 1 hour postponed. The 90% confidence interval ratio (fed: fasted) for AUC0–24 was 0.81–0.91 and for C24 0.82–0.92 (both P < 0.001). The majority (60%) had no significant change, but the change in AUC0–24 ranged from −38% to +29%. One trough level was below the target range after fed intake.

Conclusions:
When Tac ONCE-DAILY is ingested with standard continental breakfast, AUC0–24 and C24 decrease overall, with C24 in the therapeutic range in almost all patients. The convenient fed intake could promote therapy adherence. Given the possible significant change in exposure, we advise monitoring of the tacrolimus trough level 1 week after fed ingestion of Tac ONCE-DAILY.
Ecology, molecules and colour: Multivariate species delimitation and conservation of Harlequin poison frogs
Authors: Posso-Terranova Andres , Andres Jose A. 
Published: April 2016

AbstractWe propose a iterative protocol for delimiting species under the generalized lineage concept (GLC) based on the multivariate clustering of morphological, ecological, and genetic data. Our rationale is that the resulting groups should correspond to evolutionarily independent metapopulation lineages because they reflect the common signal of different secondary defining properties (ecological and genetic distinctiveness, morphological diagnosability, etc.), implying the existence of barriers preventing or limiting gene exchange. We applied this method to study a group of highly endangered poison frogs, theOophaga histrionicacomplex. In our study case, we use next generation targeted amplicon sequencing to obtain a robust genetic dataset that we then combined with patterns of morphological and ecological divergence. Our analyses revealed the existence of at least five different species in the histrionica complex (three of them new to science) occurring in very small isolated populations outside any protected areas. More broadly, our study exemplifies how transcriptome-based reduction of genomic complexity and multivariate statistical techniques can be integrated to successfully identify species and their boundaries.In memoriam“I propose that each species has a distinctive life history, which include a series of stages that correspond to some of the named species concepts”Richard G. Harrison1945-2016
Corporate governance mechanisms and agency costs: cross-country analysis
Authors: Garanina Tatiana , Kaikova Elina 
Published: April 2016

PurposeThe purpose of this paper is to investigate whether specific corporate governance mechanisms, such as board size, board composition, leverage and firm size, tend to mitigate agency cost occurrence in the USA, Russia and Norway.Design/methodology/approachThe authors analyze the sample of 243 US, 196 Russian and 175 Norwegian joint stock companies for the period 2004-2012. The regression analysis is applied to test the models.FindingsIt is revealed that larger boards increase agency costs (measured by asset utilization ratio and asset liquidity ratio) in all sample companies. The proportion of female members has a very slight positive effect in US companies, a negative influence on agency costs in the Norwegian sample and is not significant in the Russian market. The authors find that the big Russian and US companies in the samples of this paper have lower agency costs.Practical implicationsThe results of this paper show which agency-mitigation mechanisms work more effectively in companies operating in the analyzed countries characterized by specific corporate governance models.Originality/valueThe main contribution of this paper to the empirical literature is that it extends the stream of agency research by introducing new, emerging markets: represented by Scandinavian (depicted by the Norwegian sample) and Russian companies. Considering that each market – US, Norwegian and Russian – represents significant distinguishing features in their institutional framework, the paper provides an important research setting in which corporate governance mechanisms can be analyzed from the perspective of a country’s peculiar characteristics. Unlike other agency cost studies, this paper accounts for the gender diversity component in the companies and contributes to gender diversity issues.
On the impact of outside blockholders’ voting power
Authors: Hugo Wang Zhonghui 
Published: April 2016

Purpose
The purpose of this paper is to complement existing research of the relationship between concentrated ownership and firm performance by theoretically exploring the impact of outside blockholders on the firm, primarily from the perspective of voting power.

Design/methodology/approach
This paper proposes theoretical propositions based on analyses and logical extension of results of the existing theoretical and empirical studies.

Findings
This paper proposes three theoretical predictions: First, voting power provides outside blockholders a necessary condition to pursue shared and private benefits of control, and it is positively correlated with blockholders’ capability of influencing firm value. Second, everything else being equal, an outside blockholder is more (less) likely to pursue private benefits than shared benefits when the equity market is efficient and when the blockholder’s voting power is less (more) than 50 per cent. Third, controlling outside blockholders can capitalize on their voting power to appoint managerial delegates and board representatives to the invested firms for the purpose of pursuing private benefits of control.

Originality/value
This paper tries to make two contributions to the corporate governance literature. First, this research relies on a new perspective to explore the relationship between ownership structure and firm value. Second, this paper presents the first theoretical argument which states that controlling outside blockholders rely on their managerial delegates and board representatives to pursue their private benefits of control.
A multi-methodology on building a corporate governance index from the perspectives of academics and practitioners for firms in Greece
Authors: Nerantzidis Michail 
Published: April 2016

PurposeThe purpose of this paper is to look inside the “black box” in corporate governance (CG) measurement, and shed some light on how to construct a transparent, reliable and valid index, considering equally both the academics and practitioners’ perspectives.Design/methodology/approachA synthesized literature review is presented and a CG index is developed combining the strengths of three different methodologies: the Delphi method, the classical test theory (CTT) and the analytic hierarchy process (AHP). This approach helps authors to break the process into separate steps and to select the appropriate techniques to support their decision regarding the norms, the criteria, the variables and the weights that someone should use to construct a CG index.FindingsThe authors’ analysis indicates that a well-designed CG index requires a combination of research methods to identify the best options to solve several methodological issues in index construction. For the application of this multi-methodology in Greece, the authors used two equal and independent samples to explore the different perspectives regarding the importance of the index criteria and sub-criteria. This process provides evidence that the opinion of academics and practitioners in Greece tend to converge. Moreover, it is found that this multi-methodology produces the highest variation in CG scores and ranking orders, as opposed to a traditional approach, in measuring CG disclosure, an important issue with econometric implications.Research limitations/implicationsThe limitations of this study are associated with the methods used.Practical implicationsThis paper provides practical implications for investors and commercial vendors. For the former, it highlights the need to be more cautious and/or suspicious when they use CG ratings, meaning that they should comprehend the base of the ratings models, and for the latter, it demonstrates the importance of enhancing the transparency in CG indices construction.Originality/valueThe value of the paper lies in improved understanding of the methodological issues in constructing CG indices. This is quite interesting because this approach could serve as a roadmap for other researchers.
Corporate governance: the impact of director and board structure, ownership structure and corporate control on the performance of listed companies on the Ghana stock exchange
Authors: Darko Josephine , Aribi Zakaria Ali , Uzonwanne Godfrey C. 
Published: April 2016

PurposeThe purpose of this paper is to examine the relationship between corporate governance and firm performance of listed Ghanaian companies.Design/methodology/approachThe paper adopts a longitudinal and cross-sectional data set of 20 sampled companies over a period of five years. The data were analyzed using a panel regression and ANOVA analysis to establish the relationship between corporate governance and firm performance. Corporate governance is defined in terms of three indices – board structure, ownership structure and corporate control, while firm performance is measured by return on assets, return on equity, net profit margin and Tobin’s Q.FindingsThe empirical results show that ownership concentration and female representation on board have a positive impact on performance. Although the results revealed no evidence to support the impact of board size and audit committee size on performance, there is significant evidence to support the fact that independent directors and audit committee frequency both adversely affect firm performance.Research limitations/implicationsThe scope of this paper can be expanded to include non-listed firms. In addition, other corporate governance mechanisms could be considered to broaden the scope of the paper.Originality/valueThis paper contributes to the scarce literature on corporate governance and firm performance in developing countries, especially in sub-Saharan Africa. The paper provides useful information that is of great value to policymakers, academics and other stakeholders.
Examining the key dimensions of mobile banking service quality: an exploratory study
Authors: Jun Minjoon , Palacios Sergio 
Published: April 2016

Purpose
– The purpose of this paper is to identify the key dimensions of mobile banking (m-banking) service quality.

Design/methodology/approach
– The authors employ the critical incident technique to unveil the key dimensions of m-banking service quality as perceived by m-banking customers, and to identify critical satisfiers/dissatisfiers among the identified dimensions.

Findings
– The analysis reveals a total of 17 dimensions of m-banking service quality: m-banking application quality (content, accuracy, ease of use, speed, aesthetics, security, diverse mobile application service features, and mobile convenience), and m-banking customer service quality (reliability, responsiveness, competence, courtesy, credibility, access, communication, understanding the customer, and continuous improvement). Of these, five dimensions, such as mobile convenience, accuracy, diverse mobile application service features, ease of use, and continuous improvement, are considered as the main sources of customer satisfaction/dissatisfaction.

Practical implications
– M-bankers, based on the identified 17 dimensions, can develop a comprehensive service quality management system, which helps them identify and overcome key obstacles to the delivery of high quality m-banking customer services.

Originality/value
– This study focusses on uncovering the key dimensions of m-banking service quality and their associated sub-dimensions specific to the context of m-banking. Theoretically, the identified dimensions and their related sub-items can serve as building blocks for further research in customer relationship management in m-banking.
WIF4InL: Web-based integration framework for Indoor location
Authors: Niu Long , Saiki Sachio , Matsumoto Shinsuke , Nakamura Masahide 
Published: April 2016

Purpose
The purpose of this paper is to establish an application platform that addresses expensive development cost and effort of indoor location-aware application (InL-Apps) problems caused by tightly coupling between InL-App and indoor positioning systems (IPSs).

Design/methodology/approach
To achieve this purpose, in this paper, the authors proposes a Web-based integration framework called Web-based Integration Framework for Indoor Location (WIF4InL). With a common data model, WIF4InL integrates indoor location data obtained from heterogeneous IPS. It then provides application-neutral application programming interface (API) for various InL-Apps.

Findings
The authors integrate two different IPS (RedPin and BluePin) using WIF4InL and conduct a comparative study which is based on sufficiency of essential capabilities of location-dependent queries among three systems: RedPin, BluePin and WIF4InL. WIF4InL supports more capabilities for the location-dependent queries. Through the data and operation integration, WIF4InL even enriches the existing proprietary IPS.

Originality/value
As WIF4InL allows the loose coupling between IPS and InL-Apps, it significantly improves reusability of indoor location information and operation.
A study on individual mobility patterns based on individuals’ familiarity to visited areas
Authors: Han Jungkyu , Yamana Hayato 
Published: April 2016

Purpose
The purpose of this paper is to clarify the correlations between amount of individual’s knowledge of a specific area and his/her visit pattern to point of interest (POI, interested places) located in the area.

Design/methodology/approach
This paper proposes a visit-frequency-based familiarity estimation method that estimates individuals’ knowledge of areas in a quantitative manner. Based on the familiarity degree, individuals’ visit logs to POIs are divided into a set of groups followed by analyzing the differences among the groups from various points of view, such as user preference, POI categories/popularity, visit time/date and subsequent visits.

Findings
Existence of statistically significant correlations between individuals’ familiarity to areas and their visit patterns is observed by our analysis using 1.4-million POI visit logs collected from a popular location-based social network (LBSN), Foursquare. There exist different skewness of the visit time and visited POI distribution/popularity with regard to the familiarity. For instance, users go to unfamiliar areas on weekends and visit POIs for cultural experiences, such as museums. A notable point is that the correlations can be detected even in the areas in home city, which have not been known so far.

Originality/value
This is the first in-depth work that studies both estimation of individuals’ familiarity and correlations between the familiarity and individuals’ mobility patterns by analyzing massive LBSN data. The methodologies used and the findings of this work can be applicable not only to human mobility analysis for sociology, but also to POI recommendation system design.
Local government transparency index: determinants of municipalities’ rankings
Authors: Araujo Joaquim Filipe Ferraz Esteves de , Tejedo-Romero Francisca 
Published: April 2016

Purpose– Cases of corruption, embezzlement, theft and fraud, abuse of discretion, favoritism, nepotism, clientelism, and abuse of power in governments have led to a growing demand from society to access public information. In response to this demand, governments have been forced to be more transparent in the conduct of their activities. The information transparency index (TI) may be conditioned by economic and political characteristics of local governments affecting the information provided. What factors influenced the index of municipal transparency? Literature about transparency is largely based on the explanations of the agency theory and the legitimacy theory. Based on the postulates of both theories, the purpose of this paper is twofold. First, study the index transparency in Spanish municipalities, and, second, determine the main features that are affecting the index of transparency.Design/methodology/approach– Data were collected from Transparency International Spain ranking and from official sources. Univariate and multivariate analysis are performed for the treatment of data.Findings– The results shows that political factors like electoral turnout, political ideology, and political competition have a significant effect on the index of transparency. Gender has no significant effect on the index of transparency.Originality/value– This study is a contribution to the growing body literature of transparency in order to understand what explains the variations of the TI among municipalities.