bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is obesity a genetic disease? Human obese transcriptome analysis in monozygotic twins
Authors: Font-Clos Francesc , Zapperi Stefano , La Porta Caterina A.M. 
Published: July 2017

ABSTRACTObesity is a pandemic disease with a critical increase in childhood. An important unanswered question is to understand if this disease is due to genetic causes or to the life-style of the subjects. To address this question, we have analyzed if monozygotic twins show the same robust transcriptomic signature (5σ, as for the Higgs Boson) that we have recently revealed in obese subjects. Our results show that our signature correlates with BMI in paired transcriptomes of monozygotic twins, suggesting that the signature does not reflect underlying genetic causes.
Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation
Authors: Vahedi-Hunter Tyler A. , Riccomagno Martin M. 
Published: July 2017

AbstractDevelopment of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance, very little is known about the cytoplasmic effectors that mediate cellular responses triggered by these guidance cues. Here we show that members of the Cas family of cytoplasmic signaling adaptors are highly phosphorylated in central projections of the DRG as they enter the spinal cord. Furthermore, we provide genetic evidence that Cas proteins act DRG-autonomously to promote fasciculation of sensory projections. These data establish an evolutionarily conserved requirement for Cas adaptor proteins during peripheral nervous system axon pathfinding. They also provide insight into the interplay between axonal fasciculation and adhesion to the substrate.
Deep convolutional and recurrent neural networks for cell motility discrimination and prediction
Authors: Kimmel Jacob C. , Brack Andrew S. , Marshall Wallace F. 
Published: July 2017

AbstractCells in culture display diverse motility behaviors that may reflect differences in cell state and function, providing motivation to discriminate between different motility behaviors. Current methods to do so rely upon manual feature engineering. However, the types of features necessary to distinguish between motility behaviors can vary greatly depending on the biological context, and it is not always clear which features may be most predictive in each setting for distinguishing particular cell types or disease states. Convolutional neural networks (CNNs) are machine learning models allowing for relevant features to be learned directly from spatial data. Similarly, recurrent neural networks (RNNs) are a class of models capable of learning long term temporal dependencies. Given that cell motility is inherently spacio-temporal data, we present an approach utilizing both convolutional and long- short-term memory (LSTM) recurrent neural network units to analyze cell motility data. These RNN models provide accurate classification of simulated motility and experimentally measured motility from multiple cell types, comparable to results achieved with hand-engineered features. The variety of cell motility differences we can detect suggests that the algorithm is generally applicable to additional cell types not analyzed here. RNN autoencoders based on the same architecture are capable of learning motility features in an unsupervised manner and capturing variation between myogenic cells in the latent space. Adapting these RNN models to motility prediction, RNNs are capable of predicting muscle stem cell motility from past tracking data with performance superior to standard motion prediction models. This advance in cell motility prediction may be of practical utility in cell tracking applications.
Organizational culture: a foundational perspective
Authors: Pietersen Charlotte 
Published: July 2017

PurposeThe purpose of this paper is to perform a typological analysis of research orientations in the field of organizational culture (OC) in order to provide a broad, original perspective on the nature of research in this field, beyond the current quantitative/qualitative dichotomy.Design/methodology/approachDocumentary analysis, consisting of a content analysis of an appropriate and conceptually convenient selection of 200 source publications, was conducted. The analysis was performed in terms of four fundamental knowledge orientations and methodologies.FindingsAn analysis and description of the chosen set of examples for each of the four types of knowledge showed that, as with other areas in the field of organizational behavior and management (and also other scholarly disciplines), the typology finds clear expression in the area of OC.Research limitations/implicationsIn view of the aim and originality of the present paper, the sample size employed is not a worrying factor as sufficient and clear examples of each of the four basic types of research orientations have been provided. It is recommended that the broadly applicable knowledge (and by implication research) orientations that were introduced here, be considered by OC researchers. The analysis of fundamental approaches to research provides an inclusive perspective on the nature of different ways of studying and understanding OC. This should assist in expanding both scholarly and practitioner horizons. It is concluded that the analysis of research in the field of OC in terms of fundamental types of human knowledge provides a unique and expanded view on research in this area.Practical implicationsAll stakeholders in the field of human resource management could benefit from taking cognizance of a broader perspective of knowledge development in the field of OC. The four-fold framework could also be utilized as a valuable source for restructuring and teaching of research methodology programs and courses in institutions of higher education, especially concerning the general need for greater attention to: theoretical (type I), and evaluation (type IV) research in management and organizational behavior.Originality/valueThe analysis of fundamental knowledge orientations provides an original and encompassing perspective on the nature of different approaches to the study and understanding of OC.
Linking transformational leadership to turnover intention in the public sector
Authors: Gyensare Michael Asiedu , Kumedzro Lucky Enyonam , Sanda Aminu , Boso Nathaniel 
Published: July 2017

PurposeThe purpose of this paper is to examine how employee engagement and affective commitment mediate the relationship between transformational leadership and voluntary turnover intention. The study also investigates the moderating role of psychological climate in the relationship between affective organisational commitment and voluntary turnover intention.Design/methodology/approachThis study employed a cross-sectional design as its framework. In addition, hierarchical linear modelling with bootstrapping analysis was conducted using data from a sample of 336 employees in a large public sector organisation in Ghana.FindingsThe results showed that transformational leadership positively influenced engagement, which was then negatively related to employee turnover intention. Furthermore, employee engagement was found to mediate the link between transformational leadership and affective organisational commitment, whereas both employee engagement and affective organisational commitment were found to mediate the link between transformational leadership and voluntary turnover intention. Finally, psychological climate was found to moderate the link between affective commitment and voluntary turnover intention.Research limitations/implicationsDespite the practical significance of this study in lessening the turnover decision of employees, the study has some limitations. Most significantly, the sample size of this cross-sectional study was small and limited to employees from only one large public sector organisation in Ghana. Findings of this study could be generalised by using large samples from other sectors and geographical areas. Furthermore, future studies should consider positive outcomes such as OCB and innovative work behaviour to help extend our conceptual framework.Originality/valueOverall, findings of this study provide tentative support to the proposition that employee engagement and affective commitment help to minimise the decision of employees to leave the organisation regardless of how they perceive the leadership style of their immediate supervisors. Most importantly, psychological climate which is referred to as individual employee perceptions of their work environment had a strong contingent effect on the negative relationship between affective commitment and turnover intention such that employees’ positive perception of the work environment weakens the link between commitment and turnover, whereas a negative perception of the working environment strengthens the relationship between commitment and turnover. As a result, employees’ positive perception of their work environment decreased their turnover intention decisions.
Corporate message strategies for global CSR campaigns
Authors: Rim Hyejoon , Song Doori 
Published: July 2017

Purpose
The purpose of this paper is to examine multinational corporations’ (MNCs) response strategy in social media to effectively communicate their international CSR practices.

Design/methodology/approach
An experiment was conducted by adopting a case of an MNC’s globalized CSR campaign in United Arab Emirates. The interaction effects of corporate communication strategy and company’s response sidedness were examined as well as a mediating role of the perceived altruism.

Findings
The current study suggests how two-sided response strategy can be applied and benefits MNCs’ international CSR campaigns. The findings demonstrate that a company’s two-sided response helps to increase people’s attitude toward the company and word-of-mouth intention through enhanced perceived altruism when the company has no prior CSR experience in a host country.

Practical implications
The current study provides insights on how to respond to negative publicity in social media. MNCs are suggested to use different response strategies based on their prior CSR experience in a host country.

Originality/value
The success of CSR depends on how consumers take the message and perceive a company’s motive of CSR. The current study examines how to best respond to the consumers’ criticism by utilizing message sidedness strategies depending on the company’s presence of CSR.
The effects of supply chain fairness and the buyer’s power sources on the innovation performance of the supplier: a mediating role of social capital accumulation
Authors: Kim Kyung-Tae , Lee Jung Seung , Lee Su-Yol 
Published: July 2017

PurposeThis study aims to examine the effects of contractual fairness and power sources on the relationship between the buyer and supplier on the innovation performance of the supplier. The mediating role of social capital accumulation between fairness, power and innovation performance was empirically explored.Design/methodology/approachHypotheses were developed to investigate the relationships between supply chain fairness, power sources, social capital and innovation performance. Using structural equation modeling, the hypotheses were tested on data of 209 responses collected from supplying firms in South Korea.FindingsThis study finds that supply chain contractual fairness and referent power use contribute to the innovation performance of the supplier through social capital accumulation between the buyer and supplier. Coercive power, in contrast, impedes the performance improvement of the supplier.Originality/valueThis study provides supply chain practitioners, academics and policy-makers with guidance on how to facilitate and enhance innovation capabilities and performance across the supply chain. By applying social capital theory, this study also provides theoretical underpinning of the literature on supply chain fairness, power and innovation.
When is it necessary to localise product packaging?
Authors: Khan Huda , Lockshin Larry , Lee Richard , Corsi Armando 
Published: July 2017

Purpose
The common market practice by global consumer brands to create localised packaging for foreign markets conflicts with findings that cast doubt on this strategy. By examining the differential influence of standard (Western) and local (Chinese) packaging on Chinese consumers’ perceptions and choice behaviour, this study aims to examine whether this strategy is effective or even necessary.

Design/methodology/approach
A pre-test first identified suitable products and brands. Using a multiple methods approach, online participants in China first rated the brands and packaging of hedonic and utilitarian products. The ratings were then validated by triangulating with the results of a discrete choice experiment that captured participants’ choice behaviour.

Findings
For hedonic products, standard packaging is rated more positively and chosen more often than local packaging. For utilitarian products, there are no differences in ratings and choice. For hedonic products, brand likeability is higher for standard packaging than for local packaging. For utilitarian products, brand likeability does not differ between the two packaging types.

Research limitations/implications
These findings cast doubt on the effectiveness of indiscriminate packaging localisation. International marketers need to rethink their approach, particularly in non-Western markets. Interviews with five brand managers in charge of major consumer brands in China revealed their actual market practice and further illuminate this study’s findings.

Originality/value
This is first study to question the common market practice of packaging localisation and investigate the differential effects of standard versus local packaging of foreign products on consumers’ perceptions and choice behaviour.
Organisational climate change is here: memory curators in the digital age
Authors: McFadzean Andrew James 
Published: July 2017

Purpose
This paper aims to describe two themes of information and knowledge management in building corporate memory through curation in complex systems. The first theme describes the skillsets of new memory curators: curation; appraisal; strategist and manager. The second theme describes four concepts that support information management in complex systems: David Snowden’s just-in-time process; Polanyi’s personal knowing; Wenger’s transactive memory system; and David Snowden’s ASHEN database schema.

Design/methodology/approach
Academic journals and professional publications were analysed for educational requirements for information professionals in complex adaptive systems.

Findings
The skills described should be readily applied and useful in a complex adaptive system with the four concepts described. The four concepts displayed features indicating each separate concept could be aligned and integrated with the other concepts to create an information sharing model based on synergy between reasoning and computing.

Research limitations/implications
Research is needed into the capability and potential of folksonomies using recordkeeping metadata and archival appraisal to support peer production information and communication systems.

Originality/value
The author has not found any research that links archival appraisal, user-generated metadata tagging, folksonomies and transactive memory systems governance policy to support digital online, co-innovation peer production.
Current and Forward‐Looking Approaches to Technological and Nutritional Improvements of Gluten‐Free Bread with Legume Flours: A Critical Review
Authors: Melini Francesca , Melini Valentina , Luziatelli Francesca , Ruzzi Maurizio 
Published: July 2017

AbstractThe gluten‐free market currently offers a range of products which can be safely consumed by patients affected by celiac disease. Nevertheless, challenges for optimal formulation remain on the way in terms of appreciable texture, flavor, and adequate nutritional characteristics. Within that framework, legumes have recently attracted attention among scientists as structure‐ and texture‐forming agents, as source of nutrients and bioactive compounds, and as a low‐glycemic‐index ingredient. This work aims at providing an updated and comprehensive overview of the advantages and disadvantages in the use of legumes in gluten‐free breadmaking. It also shows how legumes can contribute to tackling the main technological, nutritional, and organoleptic challenges. From this critical analysis, it emerged that viscoelastic properties of gluten‐free bread batter can be enhanced by the use of carob germ, chickpea, lupin, and soybean. Gluten‐free bread organoleptic acceptability can be improved by incorporating leguminous flours, such as carob, chickpea, lupin, and soybean. Moreover, a better nutritional quality of gluten‐free bread can be obtained by the addition of chickpea and soybean. Gaps and needs in the use of legumes in gluten‐free breadmaking emerged and were gathered together to have a sound basis for future studies. The technological and nutritional potential of sourdough should be more extensively exploited. Moreover, in vitro and in vivo studies should be prompted to understand the health benefits of bread formulated with legumes. A holistic approach, interfacing food science, nutrition, and health might help to have, on the market, products with improved sensory properties and nutritional profile.
Environmental filtering is the main assembly rule of ground beetles in the forest and its edge but not in the adjacent grassland
Authors: Magura Tibor , Lövei Gábor L. 
Published: July 2017

AbstractIn a fragmented landscape, transitional zones between neighboring habitats are common, and our understanding of community organizational forces across such habitats is important. Edge studies are numerous, but the majority of them utilize information on species richness and abundance. Abundance and taxonomic diversity, however, provide little information on the functioning and phylogeny of the co‐existing species. Combining the evaluation of their functional and phylogenetic relationships, we aimed to assess whether ground beetle assemblages are deterministically or stochastically structured along grassland–forest gradients. Our results showed different community assembly rules on opposite sides of the forest edge. In the grassland, co‐occurring species were functionally and phylogenetically not different from the random null model, indicating a random assembly process. Contrary to this, at the forest edge and the interior, co‐occurring species showed functional and phylogenetic clustering, thus environmental filtering was the likely process structuring carabid assemblages. Community assembly in the grassland was considerably affected by asymmetrical species flows (spillover) across the forest edge: more forest species penetrated into the grassland than open‐habitat and generalist species entered into the forest. This asymmetrical species flow underlines the importance of the filter function of forest edges. As unfavorable, human‐induced changes to the structure, composition and characteristics of forest edges may alter their filter function, edges have to be specifically considered during conservation management.
Sensory and Physical Effects of Sugar Reduction in a Caramel Coating System
Authors: Mayhew Emily J. , Schmidt Shelly J. , Lee Soo‐Yeun 
Published: July 2017

AbstractSugar reduction in processed foods is a pressing and complex problem, as sugars contribute important sensory and physical properties to foods. Composed of sugars and lipids, caramel coating systems, like the coating in caramel popcorns, exemplify this challenge. In order to probe the feasibility and consequences of sugar reduction, both sensory and physical properties were measured for 3 types of caramel coating systems. Four commonly used sugar alcohols, isomalt, maltitol, mannitol, and sorbitol, with different thermal properties and relative sweetness values were chosen to replace sugar in the caramel coating systems at 25% and 50% sugar reduction levels. Full sugar (control) and reduced sugar caramel coating samples were prepared in duplicate. Ten trained panelists participated in a 6‐wk descriptive analysis panel to define and quantify the intensity of important sensory characteristics. All 24 sensory terms generated by the panel differed significantly across caramel type and sugar replacer. Thermal properties were measured through differential scanning calorimetry, and textural properties were measured through texture profile analysis. Replacement of sugar with sugar alcohols was found to decrease the glass transition temperature and systematically alter the hardness and resilience of caramel samples. Principal component analysis of sensory and physical data revealed that caramel coating type dictates caramel aroma, aroma by mouth, taste, and aftertaste, while sugar replacer and replacement level dictate texture. This research represents the first comprehensive study of the effects of sugar reduction in a caramel coating system and suggests successful strategies for sugar reduction and key parameters to control in reduced sugar systems.
Intrahost milieu modulates production of outer membrane vesicles, vesicle‐associated Shiga toxin 2a and cytotoxicity in Escherichia coli O157:H7 and O104:H4
Authors: Bauwens Andreas , Kunsmann Lisa , Marejková Monika , Zhang Wenlan , Karch Helge , Bielaszewska Martina , Mellmann Alexander 
Published: July 2017

SummaryOuter membrane vesicles (OMVs) are important virulence tools of enterohaemorrhagic Escherichia coli (EHEC), but other biological functions of these nanostructures are unknown. We tested the hypothesis that modulation of OMV production enables EHEC to resist the intrahost environment during infection by investigating if simulated human gastrointestinal conditions affect OMV production in EHEC O157:H7 and O104:H4. All the conditions tested including a low pH, simulated ileal and colonic media, presence of mucin, intestinal epithelial cell lysate or antimicrobial peptides, as well as iron limitation, significantly increased OMV production by these pathogens. Accordingly, a maximum vesiculation in EHEC O104:H4 was observed immediately after its isolation from a patient's intestine, and rapidly decreased during passages in vitro. Most of the simulated intrahost conditions also upregulated the OMV‐associated Shiga toxin 2a (Stx2a), the major EHEC virulence factor, and, as a result, OMV cytotoxicity. The data indicates that upregulation of OMV production by the human gastrointestinal milieu contributes to EHEC survival and adaptation within the host during infection. Moreover, the intrahost increase of vesiculation and OMV‐associated Stx2a may augment EHEC virulence.
Fictitious Freedom: A Polanyian Critique of the Republican Revival
Authors: Klein Steven 
Published: July 2017

AbstractProminent republican theorists invoke anonymous orders such as the market as mechanisms that secure freedom as non‐domination. Drawing on Karl Polanyi's account of fictitious commodities and demonstration of the impossibility of a just and rational market society, this article critically scrutinizes neo‐republican assumptions regarding the market, develops an alternate social theory within which to situate the ideal of non‐domination, and illustrates the importance of this reconfiguration for the kind of collective agents and political strategies that can be expected to advance republican freedom in the economy.