bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carotid artery stenting followed by open heart surgery in 323 patients: One‐year results and influencing factors
Authors: Dong Hui , Che Wuqiang , Jiang Xiongjing , Peng Meng , Zou Yubao , Xiong Hongliang , Chen Yang , Xu Bo , Yang Yuejin , Gao Runlin 
Published: January 2018

AbstractObjectivesThe purpose of this study was to evaluate 1‐year results and influencing factors of carotid artery stenting (CAS) before open heart surgery (OHS).BackgroundCurrently, the clinical outcomes and influencing factors of CAS followed by OHS still remain controversial.MethodsThree hundred twenty‐three consecutive patients scheduled for CAS and OHS were enrolled in this study. The primary endpoint was a composite of major stroke, myocardial infarction, or death within 1 year after CAS.ResultsThe incidence of the primary endpoint was 5.6% (18/323). The Cox regression analysis revealed that an interval of ≤5 days between CAS and OHS (HR, 4.85, 95% CI, 1.87–12.58; P = 0.001), congestive heart failure (HR, 4.08, 95% CI, 1.45–11.51; P = 0.008), and renal insufficiency (HR, 4.56, 95% CI, 1.28–16.32; P = 0.020) could independently predict the incidence of the primary endpoint. The rate of the primary endpoint from CAS to 30 days after OHS was 4.6% (15/323). An interval of ≤5 days between CAS and OHS (OR, 4.51, 95% CI, 1.52–13.36; P = 0.007) and congestive heart failure (OR, 5.32, 95% CI, 1.63–17.43; P = 0.006) were identified as independent risk factors for the primary endpoint rate from CAS to 30 days after OHS by logistic regression analysis.ConclusionsCAS followed by OHS is a safe and effective treatment for patients with concomitant carotid and cardiac disease within 1‐year follow up. The interval between CAS and OHS, congestive heart failure, and renal insufficiency could obviously influence the 1‐year results.
Impact of Hydrophobic Organohybrid Silicas on the Stability of Ni2P Catalyst Phase in the Hydrodeoxygenation of Biophenols
Authors: Dierks Michael , Cao Zhengwen , Manayil Jinesh C. , Akilavasan Jeganathan , Wilson Karen , Schüth Ferdi , Rinaldi Roberto 
Published: January 2018

AbstractHydrodeoxygenation (HDO) of lignocellulose‐derived pyrolysis oils offers an option to produce fuel substitutes. However, catalyst deactivation and stability constitute a significant issue. Herein, the dependence of stability and activity of Ni2P/SiO2 HDO catalysts on the support surface polarity is addressed in detail. The support surface polarity was adjusted by copolymerizing tetraethyl orthosilicate (TEOS) with different types and amounts of organosilanes by a sol–gel process in the presence of nickel nitrate and citric acid. After thermal treatment under an inert atmosphere, Ni/SiO2 precursors were formed. They were converted into Ni2P/SiO2 catalysts by using NaH2PO2 as a PH3 source. The catalyst surface polarity was characterized by inverse gas chromatography measurements of the free energy of methanol adsorption, and specific and dispersive surface energies derived from polar and nonpolar probe molecule adsorption. The correlation between catalyst performance and support surface polarity indicates that, to prevent deactivation of the catalyst by water under reaction conditions, the affinity of the support towards polar substances must be decreased below a threshold value.
Crystal‐Plane‐Dependent Activity of Spinel Co3O4 Towards Water Splitting and the Oxygen Reduction Reaction
Authors: Liu Qianfeng , Chen Zhiping , Yan Zhao , Wang Yao , Wang Erdong , Wang Sheng , Wang Shudong , Sun Gongquan 
Published: January 2018

AbstractInsights into the relationship between the crystal planes of metal oxides and the catalytic activity of the oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and hydrogen evolution reaction (HER) are essential for developing efficient renewable energy technologies. Herein, spinel Co3O4 nanomaterials were synthesized controllably with the specified morphologies of nanocubes, nanosheets, and nanoplates with different exposed planes of {100}, {110}, and {111}, respectively. The effects of the crystal planes of Co3O4 on the activity for the OER, ORR, and HER were subsequently investigated in alkaline media. Different electrocatalytic performances are possibly attributed to the abundance ratios of Co3+/Co2+ over the different exposed planes. The surface Co3+ ions exhibit higher activity for the OER and HER, whereas the surface Co2+ ions exhibit better performance for the ORR; moreover, higher electroconductivity enhances the polarization current for ORR and HER except OER.
Understanding expert practices in order to control expert activities: The case of trading
Authors: Jardat Rémi , Meric Jérôme , Sfez Flora 
Published: January 2018

AbstractExperts are important actors of organizational control. Nevertheless, experience suggests that they must be controlled as well. This is particularly the case for traders in financial institutions. We first identify the limits of traditional control patterns when the managing the activities of experts is at stake. Hyperspecialization, which is the ability to act within different logics and multiple time horizons, suggests that multidimensional representations of these activities be adopted and made explicit, which has the potential to prevent such activities from turning problematic. By examining bank risks and conducting additional interviews with actors from bank trading services, we recommend that multiple components of complexity be preserved when dealing with expert‐related operational risks, instead of reducing this complexity to a single concept. Such an approach implies to turn back expertise against itself. Copyright © 2017 ASAC. Published by John Wiley & Sons, Ltd.
Two‐Photon Fluorescence Imaging and Therapy of Cancer Cells with Anisotropic Gold‐Nanoparticle‐Supported Porous Silicon Nanostructures
Authors: Chaix Arnaud , Rajoua Khalil , Stojanovic Vanja , El Cheikh Khaled , Bouffard Elise , Brocéro Anthony , Garcia Marcel , Maynadier Marie , Morère Alain , Gary‐Bobo Magali , Favier Frédéric , Durand Jean‐Olivier , Cunin Frédérique 
Published: January 2018

AbstractIn this work, we prepared porous silicon (pSi) nanostructures decorated with gold nanoparticles, as probes for cell tissue imaging under two‐photon excitation. We also demonstrated that the Au/pSi nanosystems induced cytotoxicity and phototoxicity under two‐photon excitation.
A Guide to Robust Statistical Methods in Neuroscience
Authors: Wilcox Rand R. , Rousselet Guillaume A. 
Published: January 2018

AbstractThere is a vast array of new and improved methods for comparing groups and studying associations that offer the potential for substantially increasing power, providing improved control over the probability of a Type I error, and yielding a deeper and more nuanced understanding of data. These new techniques effectively deal with four insights into when and why conventional methods can be unsatisfactory. But for the non‐statistician, the vast array of new and improved techniques for comparing groups and studying associations can seem daunting, simply because there are so many new methods that are now available. This unit briefly reviews when and why conventional methods can have relatively low power and yield misleading results. The main goal is to suggest some general guidelines regarding when, how, and why certain modern techniques might be used. © 2018 by John Wiley & Sons, Inc.
Incorporation of bacteriophages in polycaprolactone/collagen fibers for antibacterial hemostatic dual‐function
Authors: Cheng Weilu , Zhang Zhongyang , Xu Ruodan , Cai Panpan , Kristensen Peter , Chen Menglin , Huang Yudong 
Published: January 2018

AbstractEffective and affordable, antibacterial and hemostatic materials are of great interests in clinical wound care practices. Herein, Enterobacteria phage T4 were incorporated in polycaprolactone/collagen I (PCL‐ColI) nanofibers via electrospinning in order to eradicate Escherichia coli infection and meanwhile establish hemostasis. Tensile strength of the membrane was significantly enhanced with increased PCL ratio. Those with a collagen component above 70% were demonstrated to be more hemostatic with shorter hemostatic time and smaller amount of bleeding. On the other hand, the T4 phage incorporated PCL‐ColI membrane (PCL:ColI = 30%/70%, w/w) exhibited the optimal antibacterial efficiency (above 90%). The in vivo evaluation indicated that the PCL‐ColI B (30%:70%, w/w) membrane fully degraded in 8 weeks and no obvious pathological reaction to muscle and subcutaneous layer tissues in the back of rabbit was found. The novel fibrous hemostatic materials coupled with phage therapy hold great promise in designing novel antibacterial, hemostatic wound dressings that addresses concerns of antibiotic resistance. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2588–2595, 2018.
Risk network approaches to locating undiagnosed HIV cases in Odessa, Ukraine
Authors: Smyrnov Pavlo , Williams Leslie D , Korobchuk Ania , Sazonova Yana , Nikolopoulos Georgios K , Skaathun Britt , Morgan Ethan , Schneider John , Vasylyeva Tetyana I , Friedman Samuel R 
Published: January 2018

AbstractIntroductionProviding HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach‐based testing or respondent‐driven sampling (RDS) in Odessa, Ukraine.MethodsThe Transmission Reduction Intervention Project (TRIP) used risk network tracing to recruit sexual and injection networks of recently‐infected and longer‐term infected (LTs) seeds (2013 to 2016). Integrated Biobehavioural Surveillance (IBBS) (2013) used RDS to recruit people who inject drugs (PWID). Outreach Testing tested PWID for HIV at community outreach sites (2013 to 2016). Proportions of undiagnosed positives among those tested were compared TRIP versus IBBS; TRIP versus Outreach Testing and between TRIP arms. Costs were compared across the projects.ResultsTRIP tested 1252 people (21% women) in seeds’ risk networks; IBBS tested 400 (18% women); Outreach Testing 13,936 (31% women). TRIP networks included a higher proportion of undiagnosed positives (14.6%) than IBBS (5.0%) or Outreach Testing (2.4%); odds ratio (OR) 3.25 (95% CI 2.07, 5.12) versus IBBS and 7.03 (CI 5.95, 8.31) versus Outreach Testing respectively. Findings remained significant in analyses stratified by sex and when PWID in TRIP networks were compared with Outreach Testing and IBBS. Within TRIP, recently‐infected participants’ networks contained higher proportions of undiagnosed positives (16.3%) than LTs’ networks (12.2%); OR 1.41 (CI 1.01, 1.95). TRIP located undiagnosed positives less expensively than did RDS or Outreach Testing.ConclusionsTRIP's recruiting techniques, including prioritizing networks of the recently infected, find undiagnosed HIV‐positive people efficiently. They should be integrated with standard practice to improve case‐finding. Research should test these techniques in other socio‐epidemiologic contexts.Clinical trial registryRegistered ClinicalTrials.gov: NCT01827228.
Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions
Authors: Deegan Anthony J. , Talebi‐Liasi Faezeh , Song Shaozhen , Li Yuandong , Xu Jingjiang , Men Shaojie , Shinohara Michi M. , Flowers Mary E. , Lee Stephanie J. , Wang Ruikang K. 
Published: January 2018

BackgroundIn clinical dermatology, the identification of subsurface vascular and structural features known to be associated with numerous cutaneous pathologies remains challenging without the use of invasive diagnostic tools.ObjectiveTo present an advanced optical coherence tomography angiography (OCTA) method to directly visualize capillary‐level vascular and structural features within skin in vivo.MethodsAn advanced OCTA system with a 1310 nm wavelength was used to image the microvascular and structural features of various skin conditions. Subjects were enrolled and OCTA imaging was performed with a field of view of approximately 10 × 10 mm. Skin blood flow was identified using an optical microangiography (OMAG) algorithm. Depth‐resolved microvascular networks and structural features were derived from segmented volume scans, representing tissue slabs of 0–132, 132–330, and 330–924 μm, measured from the surface of the skin.ResultsSubjects with both healthy and pathological conditions, such as benign skin lesions, psoriasis, chronic graft‐versus‐host‐disease (cGvHD), and scleroderma, were OCTA scanned. Our OCTA results detailed variations in vascularization and local anatomical characteristics, for example, depth‐dependent vascular, and structural alterations in psoriatic skin, alongside their resolve over time; vascular density changes and distribution irregularities, together with corresponding structural depositions in the skin of cGvHD patients; and vascular abnormalities in the nail folds of a patient with scleroderma.ConclusionOCTA can image capillary blood flow and structural features within skin in vivo, which has the potential to provide new insights into the pathophysiology, as well as dynamic changes of skin diseases, valuable for diagnoses, and non‐invasive monitoring of disease progression and treatment. Lasers Surg. Med. 50:183–193, 2018. © 2018 Wiley Periodicals, Inc.
Proline‐rich transmembrane protein 2–negative paroxysmal kinesigenic dyskinesia: Clinical and genetic analyses of 163 patients
Authors: Tian Wo‐Tu , Huang Xiao‐Jun , Mao Xiao , Liu Qing , Liu Xiao‐Li , Zeng Sheng , Guo Xia‐Nan , Shen Jun‐Yi , Xu Yang‐Qi , Tang Hui‐Dong , Yin Xiao‐Meng , Zhang Mei , Tang Wei‐Guo , Liu Xiao‐Rong , Tang Bei‐Sha , Chen Sheng‐Di , Cao Li 
Published: January 2018

ABSTRACTBackground: Paroxysmal kinesigenic dyskinesia is the most common type of paroxysmal dyskinesia. Approximately half of the cases of paroxysmal kinesigenic dyskinesia worldwide are attributable to proline‐rich transmembrane protein 2 mutations.Objective: The objective of this study was to investigate potential causative genes and clinical characteristics in proline‐rich transmembrane protein 2–negative patients with paroxysmal kinesigenic dyskinesia.Methods: We analyzed clinical manifestations and performed exome sequencing in a cohort of 163 proline‐rich transmembrane protein 2–negative probands, followed by filtering data with a paroxysmal movement disorders gene panel. Sanger sequencing, segregation analysis, and phenotypic reevaluation were used to substantiate the findings.Results: The clinical characteristics of the enrolled 163 probands were summarized. A total of 39 heterozygous variants were identified, of which 33 were classified as benign, likely benign, and uncertain significance. The remaining 6 variants (3 novel, 3 documented) were pathogenic and likely pathogenic. Of these, 3 were de novo (potassium calcium‐activated channel subfamily M alpha 1, c.1534A>G; solute carrier family 2 member 1, c.418G>A; sodium voltage‐gated channel alpha subunit 8, c.3640G>A) in 3 sporadic individuals, respectively. The other 3 (paroxysmal nonkinesiogenic dyskinesia protein, c.956dupA; potassium voltage‐gated channel subfamily A member 1, c.765C>A; Dishevelled, Egl‐10, and Pleckstrin domain containing 5, c.3311C>T) cosegregated in 3 families. All 6 cases presented with typical paroxysmal kinesigenic dyskinesia characteristics, except for the Dishevelled, Egl‐10, and Pleckstrin domain containing 5 family, where the proband's mother had abnormal discharges in her temporal lobes in addition to paroxysmal kinesigenic dyskinesia episodes.Conclusions: Our findings extend the genotypic spectrum of paroxysmal kinesigenic dyskinesia and establish the associations between paroxysmal kinesigenic dyskinesia and genes classically related to other paroxysmal movement disorders. De novo variants might be a cause of sporadic paroxysmal kinesigenic dyskinesia. © 2018 International Parkinson and Movement Disorder Society
High‐Performance Photovoltaic Detector Based on MoTe2/MoS2 Van der Waals Heterostructure
Authors: Chen Yan , Wang Xudong , Wu Guangjian , Wang Zhen , Fang Hehai , Lin Tie , Sun Shuo , Shen Hong , Hu Weida , Wang Jianlu , Sun Jinglan , Meng Xiangjian , Chu Junhao 
Published: January 2018

AbstractVan der Waals heterostructures based on 2D layered materials have received wide attention for their multiple applications in optoelectronic devices, such as solar cells, light‐emitting devices, and photodiodes. In this work, high‐performance photovoltaic photodetectors based on MoTe2/MoS2 vertical heterojunctions are demonstrated by exfoliating‐restacking approach. The fundamental electric properties and band structures of the junction are revealed and analyzed. It is shown that this kind of photodetectors can operate under zero bias with high on/off ratio (>105) and ultralow dark current (≈3 pA). Moreover, a fast response time of 60 µs and high photoresponsivity of 46 mA W−1 are also attained at room temperature. The junctions based on 2D materials are expected to constitute the ultimate functional elements of nanoscale electronic and optoelectronic applications.
Electrolytes, SEI Formation, and Binders: A Review of Nonelectrode Factors for Sodium‐Ion Battery Anodes
Authors: Bommier Clement , Ji Xiulei 
Published: January 2018

AbstractThrough intense effort in recent years, knowledge of Na‐ion batteries has been advanced significantly, pertaining to electrodes. Often, such progress has been accompanied by using a convenient choice of electrolyte or binder. Nevertheless, it has been witnessed that “external” factors to electrodes, such as electrolytes, solid electrolyte interphase, and binders, affect the functions of electrodes profoundly. And generally, certain types of electrodes favor some electrolytes or binders. With a rapidly increasing number of publications in the area, trends in terms of electrolytes and binders are possibly exploitable. Unfortunately, the field has yet to see a review article that devotes itself to these nonelectrode aspects of Na‐ion batteries. Here, the gap is filled by conducting a comprehensive review of these nonelectrode external factors, especially by looking into their correlation with electrochemical properties, such as cycle life, and first cycle coulombic efficiency. Not only are the representative reports reviewed, but also quantitative analyses on the database that are constructed are provided. With such analyses, some new data‐driven perspectives are postulated, which are of great value to the community.
Scalable Synthesis of Triple‐Core–Shell Nanostructures of TiO2@MnO2@C for High Performance Supercapacitors Using Structure‐Guided Combustion Waves
Authors: Shin Dongjoon , Shin Jungho , Yeo Taehan , Hwang Hayoung , Park Seonghyun , Choi Wonjoon 
Published: January 2018

AbstractCore–shell nanostructures of metal oxides and carbon‐based materials have emerged as outstanding electrode materials for supercapacitors and batteries. However, their synthesis requires complex procedures that incur high costs and long processing times. Herein, a new route is proposed for synthesizing triple‐core–shell nanoparticles of TiO2@MnO2@C using structure‐guided combustion waves (SGCWs), which originate from incomplete combustion inside chemical‐fuel‐wrapped nanostructures, and their application in supercapacitor electrodes. SGCWs transform TiO2 to TiO2@C and TiO2@MnO2 to TiO2@MnO2@C via the incompletely combusted carbonaceous fuels under an open‐air atmosphere, in seconds. The synthesized carbon layers act as templates for MnO2 shells in TiO2@C and organic shells of TiO2@MnO2@C. The TiO2@MnO2@C‐based electrodes exhibit a greater specific capacitance (488 F g−1 at 5 mV s−1) and capacitance retention (97.4% after 10 000 cycles at 1.0 V s−1), while the absence of MnO2 and carbon shells reveals a severe degradation in the specific capacitance and capacitance retention. Because the core‐TiO2 nanoparticles and carbon shell prevent the deformation of the inner and outer sides of the MnO2 shell, the nanostructures of the TiO2@MnO2@C are preserved despite the long‐term cycling, giving the superior performance. This SGCW‐driven fabrication enables the scalable synthesis of multiple‐core–shell structures applicable to diverse electrochemical applications.
3D‐Printed Biomaterials for Guided Tissue Regeneration
Authors: Zhang Ben , Song Jie 
Published: January 2018

AbstractFabrication of 3D scaffolds with interconnected macro‐/microporosity, compositional gradient, biological cues, and precise geometric configurations matching with that of a tissue defect, along with the choice of appropriate biomaterials, is central to the success of scaffold‐guided tissue‐regeneration strategies. Customized high‐speed 3D‐printing technology enables efficient fabrication of 3D scaffolds for regenerative‐medicine applications. In addition to recent technological advances in 3D‐printing methods and instrumentation, progress has been made in the expansion of printable biomaterials and cell‐laden bioinks. Here, a brief overview of the 3D‐printing techniques most commonly used for biomedical applications is given, followed by a discussion of common bioceramics, natural biopolymers, and synthetic degradable thermoplastic polymers, as well as their cell/biofactor‐laden composites used for 3D printing. Advantages and limitations of these printing techniques and bioinks for various tissue repair/regeneration applications are highlighted.
Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acids
Authors: Shen Chwan‐Li , Dunn Dale M. , Henry Jack H. , Li Yong , Watkins Bruce A. 
Published: January 2018

AbstractOsteoarthritic chondrocytes (OC) produce excessive prostaglandin E2 (PGE2) and nitric oxide (NO), which function as inflammation mediators in the pathogenesis of osteoarthritis (OA). This study examined the effect of CLA alone and in combination with other PUFA on the FA composition and the production of PGE2 and NO in OC cultures isolated from OA patients. Human OC were grown in monolayer and treated with one of the following PUFA treatments: CLA, CLA+arachidonic acid (CLA/AA), CLA_EPA (CLA/EPA), linoleic acid (LA), LA+AA (LA/AA), LA+EPA (LA/EPA), and ethanol (as a vehicle control) at 10 and 20 μM for 6 d. Supplementation of PUFA at 10 μM for 6 d did not introduce any cytotoxic effects or morphological changes in OC, whereas 20 μM resulted in apoptosis. Cultures of OC treated with CLA, CLA/AA, and CLA/EPA had higher concentrations of CLA isomers, and these isomers were not detected in other treatments. Supplementation of CLA or LA alone to the OC led to a lower PGE2 production compared to the control. Combination of CLA/EPA resulted in the lowest PGE2 production in cultured OC. OC cultures treated with CLA were lower in NO production than the control, whereas the LA/AA treatment demonstrated the lowest NO production. The fact that CLA alone or in combination with other PUFA modulated PGE2 and NO production in human OC cultures suggests that these 18∶2 isomers may have the potential to influence OA pathogenesis.