bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Genome Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
Authors: Yu Shirong , Evans Katie , van Eijk Patrick , Bennett Mark , Webster Richard M. , Leadbitter Matthew , Teng Yumin , Waters Raymond , Jackson Stephen P. , Reed Simon H. 
Published: April 2016

AbstractThe rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. To study this, we measured the distribution of nucleotide excision repair (NER) rates for UV-induced lesions throughout the budding yeast genome. By plotting these repair rates in relation to genes and their associated flanking sequences, we reveal that in normal cells, genomic repair rates display a distinctive pattern, suggesting that DNA repair is highly organised within the genome. Furthermore, by comparing genome-wide DNA repair rates in wild-type cells, and cells defective in the global genome-NER (GG-NER) sub-pathway, we establish how this alters the distribution of NER rates throughout the genome. We also examined the genomic locations of GG-NER factor binding to chromatin before and after UV irradiation revealing that GG-NER is organised and initiated from specific genomic locations. At these sites, chromatin occupancy of the histone acetyl transferase Gcn5 is controlled by the GG-NER complex, which regulates histone H3 acetylation and chromatin structure, thereby promoting efficient DNA repair of UV-induced lesions. Chromatin remodeling during the GG-NER process is therefore organized into these genomic domains. Importantly, loss of Gcn5, significantly alters the genomic distribution of NER rates, a finding that has important implications for the effects of chromatin modifiers on the distribution of mutations that arise throughout the genome.
Reducing torque ripple of BLDC motor by integrating DC-DC converter with three-level neutral-point-clamped inverter
Authors: V Viswanathan , S Jeevananthan 
Published: April 2016

Purpose
This paper presents a novel circuit topology based on a three-level neutral-point-clamped (NPC) inverter and a super-lift Luo-converter for minimizing torque ripple in a brushless DC motor (BLDCM) drive system. In the BLDCM, the stator winding inductance generates current ripple, distort the rectangular current shape, which produces the torque ripples. In addition, the torque ripple generates vibration, speed ripple and prevents the use of BLDCM in high-precision servo drive systems

Design/methodology/approach
Torque ripple can be mitigated by using the three-level NPC inverter, which applies half of dc-link voltage across the BLDCM terminals and this reduces the torque ripple during non-commutation period. The commutation torque ripple is reduced by employing the super-lift Luo-converter at the input of the three-level NPC inverter, which lifts the dc-link voltage to the desired value depending upon the BLDCM speed. Simulations and experimental results show that the proposed circuit topology is an attractive option to reduce the torque ripple significantly.

Findings
Experimental results show that the proposed topology can reduces the torque ripple significantly at higher speed, and operates with lower power losses than the two-level inverter-fed BLDCM drive system at higher switching frequency.

Originality/value
This paper has proposed a novel topology using a super-lift Luo-converter and a three-level NPC inverter to address the torque ripple issue in BLDCM drive system.
Determinants and logistics of e-waste recycling
Authors: Gonul Kochan Cigdem , Pourreza Saba , Tran Huguette , Prybutok Victor R. 
Published: April 2016

Purpose
– The rapid consumption of new electronic devices has expanded the volume of electronic waste (e-waste) and created a potential threat to the environment. Recycling of e-waste (eCycling) can help stem the proliferation of e-waste and its environmental threat. In order to increase this positive involvement in eCycling and design effective eCycling programs, a better understanding of eCycling behaviors is needed. The purpose of this paper is to employ the Theory of Reasoned Action as a framework to develop a model to identify the determinants of eCycling behavior.

Design/methodology/approach
– To assess the model, a survey of 327 university students is undertaken. To analyze the eCycling behavior from the survey data, a structural equation modeling technique is used.

Findings
– The findings suggest that: attitudes and moral norms positively influence eCycling behavior; the higher the awareness of consequences, the more the eCycling involvement; and perceived convenience is an important factor that leads to more involvement in eCycling.

Research limitations/implications
– This research is limited by the student sample and campus environment that might confine the generalizability of the study. Also, additional variables need to be examined in order to better explain eCycling behavior. The result of the study provides insights for organizations to build successful eCycling programs, engage young adults such as college students in eCycling, and increase involvement in eCycling.

Practical implications
– This study provides insights that can help supply chain managers to better understand the consumer involvement in eCycling. Managers’ understanding of eCycling behavior would encourage eCycling involvement by placing drop-off units in convenient locations and by creating campaigns that motivate consumers to return their e-waste. An increased consumer involvement in eCycling can help manufacturing companies lower the cost of e-waste across the supply chain and regain the value of returned materials by adopting reverse logistics.

Originality/value
– This study contributes to the stream of eCycling literature by investigating students’ eCycling intentions and behaviors on a university campus. The paper develops an understanding of how eCycling involvement might be improved.
The effect of logistics outsourcing on the supply chain vulnerability of shippers
Authors: König Alexander , Spinler Stefan 
Published: April 2016

Purpose– From a synthesis of literature, the purpose of this paper is to present a conceptual risk management framework, showing the effect of logistics outsourcing on the supply chain vulnerability (SCV) of shippers. The framework is designed to assist practitioners and academics in better understanding the key research, management as well as operational aspects involved.Design/methodology/approach– A literature review is conducted and based on these findings a conceptual framework developed.Findings– Logistics outsourcing is increasingly used by shippers, but the specific aspect of supply chain risk management (SCRM) and SCV in this context is rarely covered in research and implementation in practice is limited. Logistics outsourcing can have an ambiguous effect on the SCV of shippers and is influenced by other internal and external factors.Research limitations/implications– Literature directly dealing with logistics outsourcing and SCV/SCRM is rare and thus the framework is built on insights, compiled from the distinct research areas. Further research should be performed on this nascent topic.Practical implications– Shippers may use the framework to revise their risk management strategy and actively use logistics outsourcing to decrease SCV. Logistics service providers can tailor their services specifically toward clients and thus both can be better prepared for future supply chain disruptions.Originality/value– This paper looks specifically at SCV and SRCM of shippers with regards to logistics outsourcing.
Is workforce diversity good for efficiency? An approach based on the degree of concavity of the technology
Authors: Vandenberghe Vincent 
Published: April 2016

Purpose– The purpose of this paper is to answer the question of workforce diversity and efficiency. It departs from the rather ad hoc approach used in most recent empirical papers exploiting firm-level evidence, and suggests focusing on the estimation of the degree of concavity of the production function.Design/methodology/approach– Workforce diversity is optimal when the technology displays concavity in the share of workers considered (e.g. decreasing marginal contribution of rising shares of more productive/skilled workers). What is also shown in this paper is that a generalised version of the production functionà-la-Hellerstein-Neumark (HN) – where workforce diversity is captured via an index of labour shares – is suitable for estimating the concavity of the technology, and thus for assessing the case for/against workforce diversity.Findings– The paper contains an application to two panels of Belgian firms covering the 1998-2012 period. The main empirical result is that of an absence of strong evidence that age, gender or educational diversity is good or bad for efficiency.Originality/value– The key idea of the paper is that the degree of convacity/convexity in the share of workers considered of firm-level technology and the desirability/efficiency of workforce diversity are intrinsically connected. It is also that a non-linear/CES version of the HN labour-quality index can be used in empirical work to assess the degree of concavity/convexity of the technology and quantify the efficiency gains/losses of workforce diversity.
KULOCS: unified locating service for efficient development of location-based applications
Authors: Takatsuka Hiroki , Tokunaga Seiki , Saiki Sachio , Matsumoto Shinsuke , Nakamura Masahide 
Published: April 2016

Purpose
The purpose of this paper is to develop a facade for seamlessly using locating services and enabling easy development of an application with indoor and outdoor location information without being aware of the difference of individual services. To achieve this purpose, in this paper, a unified locating service, called KULOCS (Kobe-University Unified LOCating Service), which horizontally integrates the heterogeneous locating services, is proposed.

Design/methodology/approach
By focusing on technology-independent elements [when], [where] and [who] in location queries, KULOCS integrates data and operations of the existing locating services. In the data integration, a method where the time representation, the locations and the namespace are consolidated by the Unix time, the location labels and the alias table, respectively, is proposed. Based on the possible combinations of the three elements, an application-neutral application programming interface (API) for the operation integration is derived.

Findings
Using KULOCS, various practical services are enabled. In addition, the experimental evaluation shows the practical feasibility by comparing cases with or without KULOCS. The result shows that KULOCS reduces the effort of application development, especially when the number of locating services becomes large.

Originality/value
KULOCS works as a seamless facade with the underlying locating services, the users and applications consume location information easily and efficiently, without knowing concrete services actually locating target objects.
Co-production: what makes co-production work? Evidence from Pakistan
Authors: Farooqi Seemab Ara 
Published: April 2016

Purpose
– In developing countries there is a growing recognition that co-production offers more cost effective and responsive service delivery options in low income areas. The purpose of this paper is to explore the way co-production initiatives are managed in developing country, Pakistan.

Design/methodology/approach
– A qualitative comparative case study design is used. Data are collected through 25 semi-structured interviews and document analysis and applies institutional analysis and development framework for analysis.

Findings
– The study suggests that challenges to co-production are more than a managerial problem which require a different set of capabilities on the part of the actors in order to achieve anticipated goals in the joint production of services. Co-production initiatives require formal structures and processes to involve the local community and third sector to work with the public sector as effective partners. Political and bureaucratic commitment in regional and local government and community willingness to engage act as a catalyst for the successful management of co-production.

Originality/value
– The study extends understanding of what makes co-production work, a less researched area on co-production, drawing on a comparative analysis of two different institutional arrangements of co-production.
Contribution of internal auditing to risk management
Authors: Coetzee Philna 
Published: April 2016

Purpose
– There is a widening gap between the expectations of internal audit stakeholders and the value the function brings to the table, for example, in the management of the risks threatening an organisation. The purpose of this paper is to investigate the views of chief audit executives (CAEs), the chairs of audit committees and senior management on the contribution of the internal audit functions to risk management in the South African public sector. This contribution is considered in the context of existing risk management structures and the level of coordination between these structures and internal auditing.

Design/methodology/approach
– The views of heads of internal auditing, chairpersons of the audit committee and the Accounting Officer (similar to the CEO of private sector organisations) of national, provincial and local government organisations were obtained and statistically analysed.

Findings
– The results indicate that the CAEs have noticeably different views from the other two parties, and that the existence of risk management structures has a minor effect on how the contribution of internal auditing to risk management is perceived.

Research limitations/implications
– It was decided to not include the views of heads of risk management functions owing to the immaturity of risk management in this sector with in the South African public sector.

Practical implications
– The results of the study provide internal auditing with information on narrowing the possible gap between the perceptions of senior management and their own perceptions. Senior management could streamline the efforts of these two parties in mitigating the key risk of the organisation. The audit committee, as the independent overseer of internal auditing, will obtain information on whether internal auditing contributes to risk management, and if not, how to address these issues, taking into account the existence (or a lack thereof) of risk management structures. The legislator and regulator of public sector could be influenced to provide clearer guidance or rules in this regard in order to enhance the efficiency and effectiveness of risk management policies and practices.

Originality/value
– Limited studies have been conducted regarding the coordination of internal auditing and risk management in mitigating the key risks; especially within the public sector domain whether the existence of risk management structures would affect this coordination. Also the views of senior management, as the key stakeholder of internal auditing, on this matter have not yet been solicited.
Intelligence and its impact on managerial effectiveness and career success (evidence from insurance sector of Pakistan)
Authors: Aslam Usman , Ilyas Muhammad , Imran Muhammad Kashif , Rahman Ubaid 
Published: April 2016

Purpose– The purpose of this paper is to investigate the theoretical linear model on intelligence, i.e. emotional, social, cognitive, and cultural intelligence and its impact on managerial effectiveness and career success in the perspective of insurance sector of Pakistan.Design/methodology/approach– Data collected from 202 managers of insurance companies by using structured questionnaires’ and simple random sampling technique. Multiple regression analysis has used to check the simultaneous effect of multiple types of intelligence on managerial job outcomes.Findings– The results of research revealed that emotional, social, and cognitive intelligence have positive effect on managerial effectiveness and career success. Emotional intelligence is one of the strongest predictor that has significant impact of managerial effectiveness compared to other types of intelligence. Conversely, cultural intelligence has insignificant relation with managerial effectiveness and career success. There are very rare studies conducted to explore the role of multiple types of intelligence to improve managerial job outcomes in the context of insurance sector. This study proved that the transformation of business from production era to relationship-based era increases the importance of multiple types of intelligence to become an effective manager.Research limitations/implications– Moreover, this study contributes in theoretical literature and explores new dimensions for future researchers, practitioners’, and management consultants to recognize the effectiveness of intelligence especially in services sector organizations. Data collected from one sector and by using one point of time raised the issue of common method variance and causality.Originality/value– This study has examined the overarching model on intelligence. Researchers did not find a single study that has addressed the multiple types of intelligence and its impact on managerial outcomes in the perspective of insurance sector.
Genome‐wide mapping of transcription start sites yields novel insights into the primary transcriptome of Pseudomonas putida
Authors: D'Arrigo Isotta , Bojanovič Klara , Yang Xiaochen , Holm Rau Martin , Long Katherine S. 
Published: April 2016

SummaryThe environmental bacterium Pseudomonas putida is an organism endowed with a versatile metabolism and stress tolerance traits that are desirable in an efficient production organism. In this work, differential RNA sequencing was used to investigate the primary transcriptome and RNA regulatory elements of P. putida strain KT2440. A total of 7937 putative transcription start sites (TSSs) were identified, where over two‐thirds were located either on the opposite strand or internal to annotated genes. For TSSs associated with mRNAs, sequence analysis revealed a clear Shine–Dalgarno sequence but a lack of conserved overrepresented promoter motifs. These TSSs defined approximately 50 leaderless transcripts and an abundance of mRNAs with long leader regions of which 18 contain RNA regulatory elements from the Rfam database. The thiamine pyrophosphate riboswitch upstream of the thiC gene was examined using an in vivo assay with GFP‐fusion vectors and shown to function via a translational repression mechanism. Furthermore, 56 novel intergenic small RNAs and 8 putative actuaton transcripts were detected, as well as 8 novel open reading frames (ORFs). This study illustrates how global mapping of TSSs can yield novel insights into the transcriptional features and RNA output of bacterial genomes.
Imported Intermediate Inputs and Firms’ Productivity Growth: Evidence from the Food Industry
Authors: Olper Alessandro , Curzi Daniele , Raimondi Valentina 
Published: April 2016

AbstractImported goods play a central role in determining the gains from trade. Using detailed trade and firm‐level data for Italy and France, we investigate the relationship between trade integration, imported intermediate inputs and firm performance in the food industry. Our main findings show that an increase in import competition spurs firm‐level productivity growth. Furthermore, the productivity growth effect attributable to imported intermediate inputs is significantly stronger than the effect due to imported final products. In addition, we find that new imported inputs are of particular importance, especially for Italian food firms, though less so for the French firms. Finally, the productivity growth effect of trade integration tends to be asymmetric across firms: more productive firms gain more from trade integration. These stylised facts have interesting policy implications.
Commuting Costs and Geographic Sorting in the Housing Market
Authors: Blake Thomas 
Published: April 2016

AbstractThe demand for housing is heavily influenced by access to employment opportunities. The cost of gasoline determines, in part, the cost of such access and therefore the relative demand across markets with varying commuting needs. Locally exogenous gasoline price movements demonstrate the causal impact of higher fuel costs on housing markets: a shift of market demand toward real estate markets with less costly commutes. Higher fuel prices increase the value of real estate with shorter commutes and easier access to driving alternatives relative to more driving dependent homes. Every incremental $1 per gallon of gasoline reduces home values by 0.143% for every additional mile relative to counterfactual markets, or $5,200 for the average home and commute. This translates into a discount rate of 6.4%, comparable to mortgage rates for the period.
Short‐term outcomes of single‐port surgery for palliative resection of the primary tumor in patients with incurable stage IV colon cancer
Authors: Tei Mitsuyoshi , Wakasugi Masaki , Akamatsu Hiroki 
Published: April 2016

AbstractIntroductionThe aim of this study was to evaluate the short‐term outcomes of single‐port surgery (SPS) for palliative resection of the primary tumor in patients with incurable stage IV colon cancer.MethodsWe studied 66 consecutive patients who underwent SPS or multiport surgery (MPS) for palliative resection of their primary tumor in our department from January 2008 to December 2013. Short‐term outcomes and the postoperative course were analyzed between groups retrospectively.ResultsOf the 66 patients, 32 underwent SPS, and 34 underwent MPS. The groups did not differ significantly in terms of preoperative evaluation and short‐term outcomes. In the SPS group, one patient was converted to MPS (3.1%); no patients were converted to open surgery. Oncological resection, the proportion of patients who received postoperative chemotherapy, and time to the beginning of postoperative chemotherapy was similar in both groups. The 1‐year overall survival rates were 76.7% in the SPS group and 79.4% in the MPS group (P = 0.711).ConclusionsSPS is safe and feasible for palliative resection of the primary tumor in patients with incurable stage IV colon cancer.
Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005–2013)
Authors: Cesario L , Garrett LD , Barger AM , O'Brien RT , Fan TM 
Published: April 2016

ObjectivesThe aims of this retrospective study were to identify clinical cases of dogs with appendicular osteosarcoma (OSA) in which hepatic metastasis was confirmed, to highlight the use of cytology for its diagnosis and to describe the radiographic and ultrasonographic appearances of the lesion.MethodsMedical records were retrospectively reviewed for dogs with appendicularOSAand hepatic metastases between January 2005 and January 2013. Reviews of radiographs, ultrasounds and cytology were performed.ResultsSix dogs with appendicularOSAand hepatic metastases were identified. The ultrasonographic appearance of metastatic lesions varied, including hyperechoic with shadowing, hyperechoic without shadowing, hypoechoic and mixed echogenicity. In two cases, the hepatic metastases were also evident on thoracic radiographs. The mean survival time from diagnosis of appendicularOSAwas 188 days (range 69–363 days) and from diagnosis of hepatic metastases was 35 days (range 2–69 days). Death was tumour‐related in all cases.ConclusionsHepatic metastasis varies widely in its ultrasonographic appearance. In three of six cases, hepatic metastasis was identified without concurrent pulmonary metastasis; therefore, abdominal ultrasound may be useful at regular intervals for patient evaluation, especially in clinical trials where accurate identification of the disease‐free interval is crucial. Once hepatic metastasis is confirmed, survival times appear limited.