bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Cretaceous dinosaurian remains from the Kristianstad Basin of southern Sweden
Authors: Poropat Stephen F. , Einarsson Elisabeth , Lindgren Johan , Bazzi Mohamad , Lagerstam Clarence , Kear Benjamin P. 
Published: December 2015

Abstract

Mesozoic dinosaur fossils are exceptionally rare in Scandinavia. The Swedish record is typically depauperate, with the Kristianstad Basin of Skåne (Scania) yielding all of the known fossils from Swedish Cretaceous strata. Although highly fragmentary, these body remnants are important because they provide evidence of a relatively diverse fauna, including previously recognized hesperornithiform birds and leptoceratopsid ceratopsians, as well as indeterminate ornithopods that are confirmed here for the first time. In this paper, we describe three phalanges (from Åsen) and an incomplete right tibia (from Ugnsmunnarna) from the Kristianstad Basin. One of the phalanges appears to pertain to a leptoceratopsid ceratopsian, providing further evidence of these small ornithischians in the Cretaceous sediments of Sweden. The other two phalanges are interpreted as deriving from small ornithopods similar to
Thescelosaurus
and
Parksosaurus
. The tibia appears to represent the first evidence of a non-avian theropod dinosaur in the Cretaceous of Sweden, with a previous report of theropod remains based on fish teeth having been corrected by other authors. The remains described herein provide important additions to the enigmatic dinosaurian fauna that inhabited the Fennoscandian archipelago during the latest Cretaceous.
Early Campanian (Late Cretaceous) squatiniform and synechodontiform selachians from the Åsen locality, Kristianstad Basin, Sweden
Authors: Siversson M. , Cook T. D. , Cederström P. , Ryan H. E. 
Published: December 2015

Abstract

The latest early Campanian archipelago deposits of the Kristianstad Basin, southern Sweden, yield one of the most diverse Cretaceous chondrichthyan faunas collected from a narrow stratigraphical interval. Building on previous descriptions of various selachians, squatiniform and synechodontiform sharks are added to the faunal list. Squatinidae is represented by
Squatina
(
Squatina
)
lundegreni
sp. nov. and
Squatina
(
Squatina
)
fortemordeo
sp. nov. The poorly preserved type specimens of the nominal
Squatina hassei
from the Maastrichtian of The Netherlands were recently regarded conspecific with better preserved Santonian–Maastrichtian teeth of
Squatina
(
Cretascyllium
) from the Anglo-Paris Basin. This appears to have been based largely on the assumption that the nominal
S
.
hassei
was the only
Squatina
present in NW Europe during the Santonian–Maastrichtian. The Swedish material indicates a greater diversity of squatinoids, and the nominal
S
.
hassei
is here regarded as a
nomen dubium
of uncertain subgeneric affinity. Two types of synechodontid teeth with a tall central cusp co-occur in the Campanian of the Kristianstad Basin. Based on articulated jaws of the markedly dignathic
S
.
dubrisiensis
from the Cenomanian of England, the two morphs are regarded as upper and lower anterior teeth of the single species
S
.
filipi
sp. nov.
Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations
Authors: Riquelme Erick , Behrens Carmen , Lin Heather Y. , Simon George , Papadimitrakopoulou Vassiliki , Izzo Julie , Moran Cesar , Kalhor Neda , Lee J. Jack , Minna John D. , Wistuba Ignacio I. 
Published: December 2015

Abstract
EZH2 overexpression promotes cancer by increasing histone methylation to silence tumor suppressor genes, but how EZH2 levels become elevated in cancer is not understood. In this study, we investigated the mechanisms by which EZH2 expression is regulated in non–small cell lung carcinoma cells by oncogenic KRAS. In cells harboring KRASG12C and KRASG12D mutations, EZH2 expression was modulated by MEK–ERK and PI3K/AKT signaling, respectively. Accordingly, MEK–ERK depletion decreased EZH2 expression in cells harboring the KRASG12C mutation, whereas PI3K/AKT depletion decreased EZH2 expression, EZH2 phosphorylation, and STAT3 activity in KRASG12D-mutant cell lines. Combined inhibition of EZH2 and MEK–ERK or PI3K/AKT increased the sensitivity of cells with specific KRAS mutations to MEK–ERK and PI3K/AKT–targeted therapies. Our work defines EZH2 as a downstream effector of KRAS signaling and offers a rationale for combining EZH2 inhibitory strategies with MEK–ERK- or PI3K/AKT–targeted therapies to treat lung cancer patients, as stratified into distinct treatment groups based on specific KRAS mutations. Cancer Res; 76(3); 675–85. ©2015 AACR.
Shear stress, arterial identity and atherosclerosis
Authors: Jones Elizabeth A. , Lehoux Stephanie 
Published: December 2015

SummaryIn the developing embryo, the vasculature first takes the form of a web-like network called the vascular plexus. Arterial and venous differentiation is subsequently guided by the specific expression of genes in the endothelial cells that provide spatial and temporal cues for development. Notch1/4, Notch ligand delta-like 4 (Dll4), and Notch downstream effectors are typically expressed in arterial cells along with EphrinB2, whereas chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and EphB4 characterise vein endothelial cells. Haemodynamic forces (blood pressure and blood flow) also contribute importantly to vascular remodelling. Early arteriovenous differentiation and local blood flow may hold the key to future inflammatory diseases. Indeed, despite the fact that atherosclerosis risk factors such as smoking, hypertension, hypercholesterolaemia, and diabetes all induce endothelial cell dysfunction throughout the vasculature, plaques develop only in arteries, and they localise essentially in vessel branch points, curvatures and bifurcations, where blood flow (and consequently shear stress) is low or oscillatory. Arterial segments exposed to high blood flow (and high laminar shear stress) tend to remain plaque-free. These observations have led many to investigate what particular properties of arterial or venous endothelial cells confer susceptibility or protection from plaque formation, and how that might interact with a particular shear stress environment.
Unconscious Familiarity-based Color–Form Binding: Evidence from Visual Extinction
Authors: Rappaport Sarah J. , Riddoch M. Jane , Chechlacz Magda , Humphreys Glyn W. 
Published: December 2015

Abstract
There is good evidence that early visual processing involves the coding of different features in independent brain regions. A major question, then, is how we see the world in an integrated manner, in which the different features are “bound” together. A standard account of this has been that feature binding depends on attention to the stimulus, which enables only the relevant features to be linked together [Treisman, A., & Gelade, G. A feature-integration theory of attention. Cognitive Psychology, 12, 97–136, 1980]. Here we test this influential idea by examining whether, in patients showing visual extinction, the processing of otherwise unconscious (extinguished) stimuli is modulated by presenting objects in their correct (familiar) color. Correctly colored objects showed reduced extinction when they had a learned color, and this color matched across the ipsi- and contralesional items (red strawberry + red tomato). In contrast, there was no reduction in extinction under the same conditions when the stimuli were colored incorrectly (blue strawberry + blue tomato; Experiment 1). The result was not due to the speeded identification of a correctly colored ipsilesional item, as there was no benefit from having correctly colored objects in different colors (red strawberry + yellow lemon; Experiment 2). There was also no benefit to extinction from presenting the correct colors in the background of each item (Experiment 3). The data suggest that learned color–form binding can reduce extinction even when color is irrelevant for the task. The result is consistent with preattentive binding of color and shape for familiar stimuli.
Role of Oculoproprioception in Coding the Locus of Attention
Authors: Odoj Bartholomaeus , Balslev Daniela 
Published: December 2015

AbstractThe most common neural representations for spatial attention encode locations retinotopically, relative to center of gaze. To keep track of visual objects across saccades or to orient toward sounds, retinotopic representations must be combined with information about the rotation of one's own eyes in the orbits. Although gaze input is critical for a correct allocation of attention, the source of this input has so far remained unidentified. Two main signals are available: corollary discharge (copy of oculomotor command) and oculoproprioception (feedback from extraocular muscles). Here we asked whether the oculoproprioceptive signal relayed from the somatosensory cortex contributes to coding the locus of attention. We used continuous theta burst stimulation (cTBS) over a human oculoproprioceptive area in the postcentral gyrus (S1EYE). S1EYE-cTBS reduces proprioceptive processing, causing ∼1° underestimation of gaze angle. Participants discriminated visual targets whose location was cued in a nonvisual modality. Throughout the visual space, S1EYE-cTBS shifted the locus of attention away from the cue by ∼1°, in the same direction and by the same magnitude as the oculoproprioceptive bias. This systematic shift cannot be attributed to visual mislocalization. Accuracy of open-loop pointing to the same visual targets, a function thought to rely mainly on the corollary discharge, was unchanged. We argue that oculoproprioception is selective for attention maps. By identifying a potential substrate for the coupling between eye and attention, this study contributes to the theoretical models for spatial attention.
Improvements in Typhoon Intensity Change Classification by Incorporating an Ocean Coupling Potential Intensity Index into Decision Trees*,+
Authors: Gao Si , Zhang Wei , Liu Jia , Lin I.-I. , Chiu Long S. , Cao Kai 
Published: December 2015

AbstractTropical cyclone (TC) intensity prediction, especially in the warning time frame of 24–48 h and for the prediction of rapid intensification (RI), remains a major operational challenge. Sea surface temperature (SST) based empirical or theoretical maximum potential intensity (MPI) is the most important predictor in statistical intensity prediction schemes and rules derived by data mining techniques. Since the underlying SSTs during TCs usually cannot be observed well by satellites because of rain contamination and cannot be produced on a timely basis for operational statistical prediction, an ocean coupling potential intensity index (OC_PI), which is calculated based on pre-TC averaged ocean temperatures from the surface down to 100 m, is demonstrated to be important in building the decision tree for the classification of 24-h TC intensity change ΔV24, that is, RI (ΔV24 ≥ 25 kt, where 1 kt = 0.51 m s−1) and non-RI (ΔV24 &lt; 25 kt). Cross validations using 2000–10 data and independent verification using 2011 data are performed. The decision tree with the OC_PI shows a cross-validation accuracy of 83.5% and an independent verification accuracy of 89.6%, which outperforms the decision tree excluding the OC_PI with corresponding accuracies of 83.2% and 83.9%. Specifically for RI classification in independent verification, the former decision tree shows a much higher probability of detection and a lower false alarm ratio than the latter example. This study is of great significance for operational TC RI prediction as pre-TC OC_PI can skillfully reduce the overestimation of storm potential intensity by traditional SST-based MPI, especially for the non-RI TCs.
The impact of meticillin-resistant Staphylococcus aureus on patients with advanced cancer and their family members: A qualitative study
Authors: Gleeson Aoife , Larkin Philip , O’Sullivan Niamh 
Published: December 2015

Background: Little is known about the impact of meticillin-resistant Staphylococcus aureus on patients with advanced cancer, such as its impact on the quality of life of this vulnerable group. To date, research on meticillin-resistant Staphylococcus aureus in the palliative care setting has had a quantitative focus. Aim: The purpose of this study was to explore the impact of a meticillin-resistant Staphylococcus aureus diagnosis on patients and their carers. Design: This article reports upon a qualitative interview study of nine patients with advanced cancer and meticillin-resistant Staphylococcus aureus and nine family members ( n = 18). Framework analysis was used to analyse the data. Setting/participants: Patients and family members of patients with advanced cancer either admitted to the specialist palliative care unit or receiving palliative care in the hospital setting, who had a laboratory confirmed diagnosis of meticillin-resistant Staphylococcus aureus colonisation, were considered for inclusion in the study. Results: Four themes were identified using framework analysis: reactions to receiving a meticillin-resistant Staphylococcus aureus diagnosis, the need for effective communication of the meticillin-resistant Staphylococcus aureus diagnosis, the enigmatic nature of meticillin-resistant Staphylococcus aureus, and lessons to guide the future care of meticillin-resistant Staphylococcus aureus patients. Conclusion: This article indicates that meticillin-resistant Staphylococcus aureus can have a significant impact on advanced cancer patients and their families. This impact may be underestimated, but early and careful face-to-face explanation about meticillin-resistant Staphylococcus aureus and its implications can help patients and their families to cope better with it. These findings should be considered when developing policy relating to meticillin-resistant Staphylococcus aureus management and infection control in specialist palliative care settings.
A novel method for left anterior coronary artery flow velocity assessment by transthoracic echocardiography at the peak of a supine bicycle test
Authors: Zagatina Angela , Zhuravskaya Nadezhda , Egom Emmanuel , Kovacova Gabriela , Kruzliak Peter 
Published: December 2015

Background Assessment of coronary flow is only performed during pharmacological tests. Supine bicycle tests permit the visualization of coronary flow assessments during exercise. Purpose To assess the parameters of coronary flow in the left anterior descending artery (LAD) during exercise, which could be a sign of significant LAD narrowing. Material and Methods A total of 253 patients were enrolled: Group 1, 186 non-selective participants before undergoing a coronary angiography; and Group 2, 67 controls without coronary artery disease (CAD). All the patients performed a supine bicycle echocardiography test. Coronary flow velocities and coronary flow velocity reserve (CFVR) were measured at the mid-segment of the LAD during exercise. Patients in Group 1 underwent a coronary angiography. Results In comparison with participants without significant LAD stenosis, patients with LAD lesions had a lower ΔV (16 ± 21 vs. 27 ± 20 cm/s, P < 0.04) and a lower CFVR (1.5 ± 0.8 vs. 2.0 ± 0.6, P < 0.004). In comparison with patients without significant proximal LAD stenosis, the patients with proximal LAD lesions had a lower flow velocity at the peak of exercise (49 ± 32 vs. 61 ± 19 cm/s, P < 0.02), a lower ΔV (13 ± 19 vs. 26 ± 22 cm/s, P < 0.004), and a lower CFVR (1.4 ± 0.6 vs. 1.9 ± 0.7, P < 0.0001). In comparison with the control group, the patients with LAD stenosis had a lower flow velocity at the peak of exercise, a lower ΔV, and a lower CFVR. Conclusion Non-invasive CFVR measurement in the LAD could provide valuable additional information to a conventional echocardiography exercise test. In routine clinical practice, CFVR is sufficient for a diagnosis of severe stenosis.
The Efficacy of Injury Prevention Programs in Adolescent Team Sports
Authors: Soomro Najeebullah , Sanders Ross , Hackett Daniel , Hubka Tate , Ebrahimi Saahil , Freeston Jonathan , Cobley Stephen 
Published: December 2015

Background: Intensive sport participation in childhood and adolescence is an established cause of acute and overuse injury. Interventions and programs designed to prevent such injuries are important in reducing individual and societal costs associated with treatment and recovery. Likewise, they help to maintain the accrual of positive outcomes from participation, such as cardiovascular health and skill development. To date, several studies have individually tested the effectiveness of injury prevention programs (IPPs). Purpose: To determine the overall efficacy of structured multifaceted IPPs containing a combination of warm-up, neuromuscular strength, or proprioception training, targeting injury reduction rates according to risk exposure time in adolescent team sport contexts. Study Design: Systematic review and meta-analysis. Methods: With established inclusion criteria, studies were searched in the following databases: Cochrane Central Register of Controlled Trials, MEDLINE, SPORTDiscus, Web of Science, EMBASE, CINAHL, and AusSportMed. The keyword search terms (including derivations) included the following: adolescents, sports, athletic injuries, prevention/warm-up programs. Eligible studies were then pooled for meta-analysis with an invariance random-effects model, with injury rate ratio (IRR) as the primary outcome. Heterogeneity among studies and publication bias were tested, and subgroup analysis examined heterogeneity sources. Results: Across 10 studies, including 9 randomized controlled trials, a pooled overall point estimate yielded an IRR of 0.60 (95% CI = 0.48-0.75; a 40% reduction) while accounting for hours of risk exposure. Publication bias assessment suggested an 8% reduction in the estimate (IRR = 0.68, 95% CI = 0.54-0.84), and the prediction interval intimated that any study estimate could still fall between 0.33 and 1.48. Subgroup analyses identified no significant moderators, although possible influences may have been masked because of data constraints. Conclusion: Compared with normative practices or control, IPPs significantly reduced IRRs in adolescent team sport contexts. The underlying explanations for IPP efficacy remain to be accurately identified, although they potentially relate to IPP content and improvements in muscular strength, proprioceptive balance, and flexibility. Clinical Relevance: Clinical practitioners (eg, orthopaedics, physical therapists) and sports practitioners (eg, strength and conditioners, coaches) can respectively recommend and implement IPPs similar to those examined to help reduce injury rates in adolescent team sports contexts.
Attention-related changes in short-term cortical plasticity help to explain fatigue in multiple sclerosis
Authors: Conte Antonella , Li Voti Pietro , Pontecorvo Simona , Quartuccio Maria Esmeralda , Baione Viola , Rocchi Lorenzo , Cortese Antonio , Bologna Matteo , Francia Ada , Berardelli Alfredo 
Published: December 2015

Background: In multiple sclerosis (MS), pathophysiology of fatigue is only partially known. Objective: The aim of this study was to investigate whether the attention-induced modulation on short- and long-term cortical plasticity mechanisms in primary motor area (M1) is abnormal in patients with MS-related fatigue. Methods: All participants underwent 5-Hz repetitive transcranial magnetic stimulation (rTMS), reflecting short-term plasticity, and paired associative stimulation (PAS), reflecting long-term plasticity, and were asked to focus their attention on the hand contralateral to the M1 stimulated. A group of age-matched healthy subjects acted as control. Results: In patients with MS, 5-Hz rTMS and PAS failed to induce the normal increase in motor-evoked potential (MEP). During the attention-demanding condition, 5-Hz rTMS- and PAS-induced responses differed in patients with MS with and without fatigue. Whereas in patients with fatigue neither technique induced the attention-induced MEP increase, in patients without fatigue they both increased the MEP response, although they did so less efficiently than in healthy subjects. Attention-induced changes in short-term cortical plasticity inversely correlated with fatigue severity. Conclusion: Short-term and long-term plasticity mechanisms are abnormal in MS possibly owing to widespread changes in ion-channel expression. Fatigue in MS reflects disrupted cortical attentional networks related to movement control.
Ultra-high field MTR and qR2* differentiates subpial cortical lesions from normal-appearing gray matter in multiple sclerosis
Authors: Jonkman Laura E , Fleysher Lazar , Steenwijk Martijn D , Koeleman Jan A , de Snoo Teun-Pieter , Barkhof Frederik , Inglese Matilde , Geurts Jeroen JG 
Published: December 2015

Background: Cortical gray matter (GM) demyelination is frequent and clinically relevant in multiple sclerosis (MS). Quantitative magnetic resonance imaging (qMRI) sequences such as magnetization transfer ratio (MTR) and quantitative R2* (qR2*) can capture pathological subtleties missed by conventional magnetic resonance imaging (MRI) sequences. Although differences in MTR and qR2* have been reported between lesional and non-lesional tissue, differences between lesion types or lesion types and myelin density matched normal-appearing gray matter (NAGM) have not been found or investigated. Objective: Identify quantitative differences in histopathologically verified GM lesion types and matched NAGM at ultra-high field strength. Methods: Using 7T post-mortem MRI, MRI lesions were marked on T2 images and co-registered to the calculated MTR and qR2* maps for further evaluation. In all, 15 brain slices were collected, containing a total of 74 cortical GM lesions and 45 areas of NAGM. Results: Intracortical lesions had lower MTR and qR2* values compared to NAGM. Type I lesions showed lower MTR than type III lesions. Type III lesions showed lower MTR than matched NAGM, and type I and IV lesions showed lower qR2* than matched NAGM. Conclusion: qMRI at 7T can provide additional information on extent of cortical pathology, especially concerning subpial lesions. This may be relevant for monitoring disease progression and potential treatment effects.
Outcomes of release of the entire A4 pulley after flexor tendon repairs in zone 2A followed by early active mobilization
Authors: Moriya K. , Yoshizu T. , Tsubokawa N. , Narisawa H. , Hara K. , Maki Y. 
Published: December 2015

We report the outcomes of repair of the flexor digitorum profundus tendon in zone 2a in 22 fingers. The tendon was repaired with a six-strand repair method and the A4 pulley was completely released. Release of the C2 pulley combined with the A4 pulley was necessary in 12 fingers, nine fingers underwent a complete release of the A3, C2, and A4 pulleys, and one finger underwent a release of the C1, A3, C2, and A4 pulleys. The mean total active motion of the three finger joints was 234° at 5 to 12 months of follow-up. No bowstringing was noted in these fingers. The good and excellent recovery of active digital motion was in 20 (91%) out of 22 fingers according to Strickland’s criteria or Tang’s criteria. Our results suggest that release of the A3, C2, and A4 pulleys makes the repair surgery easier and does not cause tendon bowstringing. Level of Evidence: IV