bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced gelatin methacryloyl nanohydroxyapatite hydrogel for high-fidelity 3D printing of bone tissue engineering scaffolds
Authors: Naolou Toufik , Schadzek Nadine , Pepelanova Iliyana , Frommer Miriam , Hornbostel Jan Mathis , Lötz Franziska , Sauheitl Leopold , Dultz Stefan , Felde Vincent J. M. N. L. , Myklebost Ola , Lee-Thedieck Cornelia 
Published: February 2025

Abstract
Patients suffering from large bone defects are in urgent need of suitable bone replacements. Besides biocompatibility, such replacements need to mimic the 3D architecture of bone and match chemical, mechanical and biological properties, ideally promoting ossification. As natural bone mainly contains collagen type I and carbonate hydroxyapatite, a 3D-printable biomaterial consisting of methacrylated gelatin (GelMA) and nanohydroxyapatite (nHAp) would be beneficial to mimic the composition and shape of natural bone. So far, such nanocomposite hydrogels (NCH) suffered from unsatisfactory rheological properties making them unsuitable for extrusion-based 3D printing with high structural fidelity. In this study, we introduce a novel GelMA/nHAp NCH composition, incorporating the rheological modifier carbomer to improve rheological properties and addressing the challenge of calcium cations released from nHAp that hinder GelMA gelation. Leveraging its shear-thinning and self-healing properties, the NCH ink retains its shape and forms cohesive structures after deposition, which can be permanently stabilized by subsequent UV crosslinking. Consequently, the NCH enables the printing of 3D structures with high shape fidelity in all dimensions, including the z-direction, allowing the fabrication of highly macroporous constructs. Both the uncured and the UV crosslinked NCH behave like a viscoelastic solid, with G´>G´´ at deformations up to 100-200 %. After UV crosslinking, the NCH can, depending on the GelMA concentration, reach storage moduli of approximately 10 to over 100 kPa and a mean Young’s Modulus of about 70 kPa. The printed scaffolds permit not only cell survival but also osteogenic differentiation, highlighting their potential for bone tissue engineering.
Optical parametric amplification near resonance transition in two-level system
Authors: Stepanov Serguei , Casillas Rodriguez Nayeli , Ocegueda Manuel Ivan , Montoya Jorge , Domínguez-Serna Francisco Antonio , Garay Karina 
Published: February 2025

Abstract
Abstract. We present results of a theoretical analysis of an optical parametric amplification (OPA) in a collinear nearly degenerate four-wave mixing (FWM) configuration close to the resonance of a two-level transition in χ''' media. It is performed both for homogeneously and for inhomogeneously broadened spectral line using a standard set of Bloch equations in the semiclassical approximation. Unlike the traditional approach of a coupled propagation of the signal/idler waves, we treat OPA as a coupled propagation of the amplitude and phase modulations of the pump wave with the signal/idler waves as the modulation sidebands. We show that for low frequency off-sets between the pump and the signal/idler waves, OPA process is basically manifested in a unidirectional transformation of the input amplitude modulation of the pump wave into the output phase modulation. The frequency band of the OPA is determined by detuning the pump wave from the resonance transition. The obtained results are applied to evaluate the expected OPA gain for the acetylene-filled micro-structured fiber with the resonance vibration-rotational transitions in the 1500-1550nm spectral range.&#xD;
Exploring the application of deep learning methods for polygenic risk score estimation
Authors: Squires Steven , Weedon Michael N. , Oram Richard A. 
Published: February 2025

Abstract
Background:&#xD;Polygenic risk scores (PRS) summarise genetic information into a single number with clinical and research uses. Machine learning (ML) has revolutionised multiple fields, however, the impact of ML on PRSs has been less significant. We explore how ML can improve the generation of PRSs.&#xD;Methods:&#xD;We train ML models on known PRSs using UK Biobank data. We explore whether the models can recreate human programmed PRSs, including using a single model to generate multiple PRSs, and ML difficulties in PRS generation. We investigate how ML can compensate for missing data and constraints on performance.&#xD;Results:&#xD;We demonstrate almost perfect generation of multiple PRSs with little loss of performance with reduced quantity of training data. For an example set of missing SNPs the MLP produces predictions that enable separation of cases from population samples with an area under the receiver operating characteristic curve of 0.847 (95% CI: 0.828-0.864) compared to 0.798 (95% CI: 0.779-0.818) for the PRS.&#xD;Conclusions:&#xD;ML can accurately generate PRSs, including with one model for multiple PRSs. The models are transferable and have high longevity. With certain missing SNPs the ML models can improve on PRS generation. Further improvements likely require use of additional input data.&#xD;
Two-photon interference at a telecom wavelength for quantum networking
Authors: Cohen Mathis , Labonté Laurent , Dalidet Romain , Tanzilli Sebastien , Martin Anthony 
Published: February 2025

Abstract
The interference between two independent photons stands as a crucial aspect of numerous quantum information protocols and technologies. In this work, we leverage fiber-coupled devices, which encompass fibered photon pair-sources and off- the-shelf optics, to demonstrate Hong-Ou-Mandel interference. We employ two distinct single photon sources, namely an heralded single-photon source and a weak coherent laser source, both operating asynchronously in continuous-wave regime. We record two-photon coincidences, showing a state-of-art visibility of 91.9(5)%. This work, compliant with telecom technology provides realistic backbones for establishing long- range communication based on quantum teleportation in hybrid quantum networks.
Warming structure of the Kuroshio in the East China Sea since 1970
Authors: Li Xiaoqian , Li Yuanlong , Ge Kai , Tang Xiaohui , Liu Shouhua , Zhu Shanliang 
Published: February 2025

Abstract
The Kuroshio Current (KC) has witnessed rapid surface warming during the past half-century, impacting the marine ecosystems in surrounding regions. However, the vertical structure of the warming KC remains unclear. This study utilizes historical hydrographic observational data and ocean model experiments to investigate temperature changes of the KC in the East China Sea since 1970. The KC at the Pollution Nagasaki (PN) section has shown rapid warming in the upper 350 m and insignificant warming or cooling trends in the subsurface layer of 350-800 m. A decomposition of heaving and spicing modes indicates that the rapid upper-layer warming occurs primarily in heaving, whereas the subsurface cooling arises from Spicing. In addition to surface heating, surface wind changes over the subtropical North Pacific – induced by the phase shift of the Pacific Decadal Oscillation (PDO) – also enhance the upper-layer warming of the KC by driving downwelling Rossby waves. The subsurface cooling reflects property changes of the North Pacific Intermediate Water (NPIW) which can be traced to buoyancy fluxes in the subpolar northwestern Pacific. By linking the regional changes observed in the ECS to basin-scale processes over the North Pacific, this work contributes to the understanding of the response of the KC to climate change.&#xD;
Changes in land use waves and ecosystem service values ​​in Vietnam: research in the Northern midlands and mountainous regions (NMR) from 1990 to 2020
Authors: Tran Phuong Trong , Nguyen Tuan Tran 
Published: February 2025

Abstract
Land use is increasingly influencing ecosystem services (ES) in Vietnam. However, in Vietnam, there have not been many studies addressing the quantification of ecosystem service values (ESV) as well as the relationship between land use conversion and ES from a spatial perspective. This study seeks to address this deficiency by analyzing the land use changes (LUC) and the ESV in 14 provinces within Vietnam’s NMR. The study used several indicators to assess LUC. These indicators include S (single land-use level), I (integrated land-use level), LUI (land-use intensity), LUM (mixed land-use entropy index), and LUD (land-use diversity). Furthermore, the study takes into account the ESVaver (average ecosystem service value) index. The research findings indicate that the shrub underwent the most significant changes in nearly every stage across all 14 localities. With the LUI index, the period 1990–1995 shows that there are localities with the highest level of adaptation, with adaptation levels ranging from 4.15 to 8.74 in three western provinces of the region. The LUD and LUM indexes reveal a high level of complexity in land use types during the periods 2000–2005 and 2015–2020. This shows that the level of diversity in land use in most localities is increasing day by day. Meanwhile, in the NMR region, the ESV shows a slight increase in the first 5 years of the study, followed by a series of gradual decreases until 2020, with 67,647.56 million US$/ha/year. During its initial rise, the ESVaver index exhibited a similar trend. From 1995 to 2005, it dropped sharply. The results of this study will enable researchers and decision-makers to formulate effective policies in the future.&#xD;
Recent changes in rainfall patterns alter precipitation partitioning in European beech forest
Authors: Drollinger Simon , Dietze Michael , Seidel Dominik , Schwindt Daniel , Birk Jago Jonathan , Sauer Daniela 
Published: February 2025

Abstract
Climate change models suggest increasing rain variability in Europe with hypothesized cascading effects on ecosystems. However, model results are inconsistent, coarse and lack empirical data. Here, we used a 6.5-year dataset of gross precipitation, throughfall, and plant litter deposition from a beech forest in central Germany to show how water that reaches the Critical Zone is driven by shifting rainfall characteristics and canopy structure. Rain event duration declined distinctly over the observation period, while rain intensity and event frequency increased. These changes caused the throughfall fraction to decrease by 5.75% per year and spatial throughfall variability to rise exponentially. This study provides empirical evidence that precipitation intensification strongly impacts the spatio-temporal distribution of net precipitation in beech forests. This may progressively decouple hydrological links in Europe’s most dominant forest stands, potentially resulting in changing water and element fluxes, weathering, and soil processes.
Low-Cost Compact Wi-Fi Energy Harvesting Rectifier Using Semi-Lumped Elements
Authors: Issa Hamza 
Published: February 2025

Abstract
The increasing demand for low-power wireless devices has driven innovation in energy harvesting technologies, with Wi-Fi signals emerging as a viable source of ambient energy. This paper presents a novel Wi-Fi energy harvesting rectifier designed to maximize energy conversion efficiency while maintaining simplicity, compactness, and affordability. Utilizing a semi-lumped matching network fabricated on a low-cost FR4 substrate, our design achieves a notable efficiency of 47% at 0 dBm and 55% at 8 dBm within a compact footprint of 263 mm².&#xD;Compared to existing works, which often employ complex and expensive substrates like&#xD;Rogers RT/duroid 5880, our approach offers a practical balance of performance, size, and cost, making it suitable for widespread applications. This study uniquely contributes to the field by demonstrating high efficiency using a semi-lumped rectifier on a high-loss, low-cost substrate, offering a promising solution for cost-effective Wi-Fi energy harvesting. The outcomes of this work will be compared and discussed against existing designs to highlight its advantages and potential applications.&#xD;
Assessing the Suitability of the Langevin Equation for Analyzing Measured Data Through Downsampling
Authors: Lin Pyei Phyo , Wächter Matthias , Peinke Joachim , Rahimi Tabar Mohammed Reza 
Published: February 2025

Abstract
The measured time series from complex systems are renowned for their&#xD;intricate stochastic behavior, characterized by random fluctuations stemming from&#xD;external influences and nonlinear interactions. These fluctuations take diverse forms,&#xD;ranging from continuous trajectories reminiscent of Brownian motion to noncontinuous&#xD;trajectories featuring jump events. The Langevin equation serves as a powerful tool&#xD;for generating stochasticity and capturing the complex behavior of measured data with&#xD;continuous stochastic characteristics. However, the traditional modeling framework of&#xD;the Langevin equation falls short when it comes to capturing the presence of abrupt&#xD;changes, particularly jumps, in trajectories that exhibit non-continuity. Such non-&#xD;continuous changes pose a significant challenge for general processes and have profound&#xD;implications for risk management. Moreover, the discrete nature of observed physical&#xD;phenomena, measured with a finite sample rate, adds another layer of complexity. In&#xD;such cases, data points often appear as a series of discontinuous jumps, even when the&#xD;underlying trajectory is continuous. In this study, we present an analytical framework&#xD;that goes beyond the limitations of the Langevin equation. Our approach effectively&#xD;distinguishes between diffusive or Brownian-type trajectories and trajectories with&#xD;jumps. By employing downsampling techniques, where we artificially lower the sample&#xD;rate, we derive a set of measures and criteria to analyze the data and differentiate&#xD;between diffusive and non-diffusive behaviors. To further demonstrate its versatility&#xD;and practical applicability, we have applied our proposed method to real-world data in&#xD;various scientific fields, turbulence, optical tweezers for trapped particles, neuroscience,&#xD;renewable energy, and market price analysis.
Effects of Heat and Pressure Loading on Erythema and Skin Microclimate at Pressure-Prone Areas of Semirecumbent Healthy Adults
Authors: Borzdynski Caroline , Miller Charne , McGuiness Bill 
Published: February 2025

ABSTRACT

BACKGROUND
Altered localized microclimate conditions are known to increase the risk of pressure injuries in immobile patients. Limited in vivo studies have examined how skin properties change over time and under different skin microclimate conditions.

OBJECTIVE
To examine changes in erythema, stratum corneum hydration, and skin temperature in response to an altered microclimate, simulated by the introduction of heat, at the skin–support surface interface of semirecumbent healthy adults.

METHODS
In this quasi-experimental study, researchers obtained noninvasive biophysical skin measures at the elbows, heels, and sacrum of healthy adults positioned semirecumbently. Participants advanced through a controlled condition and heat intervention. Repeated measures were gathered at the anatomic sites every 10 minutes for 60 minutes per condition. Linear mixed models were used to compare skin measures over time and between conditions.

RESULTS
Large regional variation in skin measures emerged by condition and among participants. The introduction of heat increased skin temperature at the heels (P < .001), elbows (P = .005), and sacrum (P < .001). Erythema increased at the sacrum (P = .012) but at no other anatomic testing site. There was no impact on stratum corneum hydration as a result of increased heat at any anatomic testing site.

CONCLUSIONS
More frequent monitoring cycles for erythematous skin discoloration and thermal changes may be required at the sacral skin in immobile patients. Distinctive protocols in relation to skin-care regimens may be warranted for individual patients. Skin cooling, enabled by intermittent off-loading of pressure-prone areas, may assist optimization of the skin microclimate.
Rescue Pneumatic Retinopexy for Retinal Detachment in Vitrectomized Eyes
Authors: Adams Olufemi E. , Kumar Sandeep , Pecaku Aurora , Shroff Daraius , Rizvi Fatima , Momenaei Bita , Yu Michael D. , Klufas Michael A. , Muni Rajeev H. , Yonekawa Yoshihiro 
Published: February 2025

Purpose:
To report the visual and anatomic outcomes of pneumatic retinopexy (PnR) in vitrectomized eyes.

Methods:
This was a retrospective multi-center study evaluating eyes 1) treated with PnR for rhegmatogenous retinal detachment (RRD) that 2) had a prior history of pars plana vitrectomy (PPV) for any indication. At least 3 months of follow-up was required.

Results:
A total of 38 eyes from 38 patients met inclusion criteria. Retinal reattachment after a single PnR was achieved in 71.1% (27/38). The primary anatomic reattachment rate (PARR) was 100% (12/12) for eyes which previously underwent PPV for indications other than RRD, but lower (57.7%; 15/26) for those with a history of RRD repair (p<0.001). Median logMAR VA (Snellen equivalent) improved from 0.74 (20/110) to 0.48 (20/60) at 3 months (p=0.004), 0.44 (20/55) at 6 months (p=0.002), 0.35 (20/45) at 12 months (p=0.007), and 0.30 (20/40) at the final visit (p=0.007).

Conclusion:
PnR may be a useful and less invasive rescue technique to reattach the retina in previously vitrectomized eyes with a RRD, especially in those without prior RRD history.
Blood Parechovirus RT-PCR Testing in Neonates and Infants: Comparison of Clinical and Biologic Features With Those of Enterovirus Infections
Authors: Archimbaud Christine , Dommergues Marie-Aliette , Lafolie Jeremy , Pereira Bruno , Verdan Matthieu , Adam Marie Noelle , Madhi Fouad , L’Honneur Anne-Sophie , Mirand Audrey , Bailly Jean-Luc , Henquell Cécile , Marque-Juillet Stéphanie ,   on Behalf of the Blood Enterovirus Diagnosis Infection (BLEDI) Group in the Pediatric Population Study Team
Published: February 2025

Background:
To assess human parechovirus (HPeV) detection by real-time polymerase chain reaction in blood with or without cerebrospinal fluid samples in neonates and infants and compare the clinical and biological characteristics of HPeV patients with those of patients with or without enterovirus (EV) infection.

Methods:
In all, 92 HPeV-infected patients (40 newborns and 52 infants) presenting with fever without source, sepsis-like disease or suspected meningitis were evaluated in 2 French hospitals from 2007 to 2018. The clinical and biological characteristics of HPeV patients were compared with those of 100 EV-infected patients and of 95 control patients with fever without source or sepsis-like disease.

Results:
HPeV was detected more frequently in blood [100% (51/51)] than in cerebrospinal fluid specimens [89% (67/75), P = 0.02]. Genotyping identified HPeV3 in 76/85 (89%) positive specimens. HPeV-infected patients were more likely than EV-infected or control patients to have sepsis-like disease and required more frequent vascular filling (39% in newborns and 26% in infants) and empirical antibiotics (91% in newborns and 69% in infants). HPeV patients had lower peripheral white blood cell counts and lower lymphocyte levels (P = 0.002) and longer lengths of hospital stay than EV or control patients (P = 0.03). A white blood cell count <7×109/L can be helpful in differentiating HPeV patients from control patients.

Conclusions:
Detection of HPeV should be part of the differential diagnosis of EV infections. The use of small automata to perform real-time polymerase chain reaction assays in emergency units should allow faster diagnosis and, if the result is positive, avoid prolonged length of hospital stay and unnecessary administration of antibiotics in patients without virus-bacteria co-infection.
Identifying Health Services Preferences for a Community-Based HIV Status–Neutral Mobile Clinic Among Marginalized Populations in Oakland, CA: A Maximum-Difference Analysis
Authors: Gutierrez Jose I. , Nguyen Elizabeth S. , Soriano Kristin D. , Rodriguez Garcia Lidia , Liu Albert , Wilson Natalie L. 
Published: February 2025

Abstract
Leveraging patient preferences can improve patient satisfaction and engagement in intentional health services. We explored desired health services preferences of marginalized populations accessing HIV-related care engagement to inform the implementation of an HIV prevention and treatment mobile clinic model. We conducted a maximum-difference survey with 154 people at community events and homeless encampments in Oakland, CA. Participants ranked 32 items in differentials of importance on a tablet, which were analyzed with Hierarchical Bayesian modeling. Fourteen services were prioritized, including housing, mental health counseling and screening, drug overdose prevention, personal hygiene, and food assistance. Participants indicated preferences for services that address basic physiological and safety needs (i.e., housing services, food, personal hygiene supplies, drug overdose treatment, and mental health support and engagement), physical examinations, screenings, and medication refills. Incorporating community-informed preferences into the development of services may improve engagement in care alongside a syndemic approach toward ending the HIV epidemic.
Reliability and Validity of the Survey on Activities of Daily Living and Occupations of Upper Extremity Amputees’ Turkish Version
Authors: Bebek Aslı , Karahan Sevilay , Topuz Semra 
Published: February 2025

ABSTRACT

Introduction
The purpose of this study was to investigate the cross-cultural adaptation, validity, and reliability of the Turkish version of the Survey on Activities of Daily Living and Occupations of Upper Extremity Amputees (ADLO-UEA).

Methods
The translation of the questionnaire from English into Turkish and intercultural adaptation were carried out in accordance with the rules of the Beaton translation methods. A total of 125 individuals with upper-limb amputation participated to the study. A test and a retest were administered to the participants within 72 hours. Reliability coefficients were calculated. Statistical analyses were performed to determine these coefficients, including the calculation of Cronbach α using the IBM SPSS Statistics 21, Chicago, IL, USA, program. Validity analysis was performed using the Spearman correlation test. The Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire and visual analog scale (VAS) were used for the validity analyses. Internal consistency (intraclass correlation coefficient [ICC]) of the Turkish version was calculated.

Results
As a result of reliability analysis, positive correlation was found between test and retest (ICC = 0.969). In the question of satisfaction level with the prosthesis, a positive correlation was determined between test and retest (r = 0.93, P < 0.001). In the activities of daily living section, a positive correlation was observed between the test and retest for all items (P < 0.001). There was also a positive correlation between total scores (Kaiser-Meyer-Olkin [KMO] = 0.940; P < 0.001). The Spearman correlation coefficient of 0.55 indicated a significant moderate negative correlation between the total score of the ninth section of daily living activities and the total DASH score (r = −0.884, P < 0.001).

Conclusions
It was concluded that the Turkish translation of the survey is valid, reliable, and can be used for individuals with upper-limb amputation.

Clinical Relevance
With this study, a comprehensive survey was provided to health care professionals working with individuals with upper-limb amputation. Persons with upper-limb amputation can explain their daily living activities more easily by using the questionnaire.