bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Transition of Care Between Emergency Department and Primary Care: An Integrative Systematic Review
Authors: Hain Kathleen , Scarvell Jennie M. , Paterson Catherine 
Published: September 2024

ABSTRACTAimsTo identify the barriers and enablers of effective transitions of care between the emergency department and primary care providers.BackgroundSuccessful patient care transitions from the emergency department to primary care providers are important because this process has implications for the quality, patient safety, and cost of patient care. Failure in follow‐up consultations with primary care can result in representations to the emergency department, which can impact negative emergency department operational issues throughout the entire hospital.Design and MethodsAn integrative systematic review was reported according to PRISMA guidelines. The reviewers followed a systematic review protocol registered with PROSPERO (CRD42022316165). A search strategy was applied to extract articles from included databases: CINAHL, MEDLINE, PsycINFO, Scopus, ProQuest Nursing and Allied Health databases. Articles were assessed using a predetermined eligibility criterion. Quality assessment and a narrative synthesis were conducted.ResultsOf the 1200 articles screened, 25 studies were included. Four additional articles were identified from reference lists. The range of study designs included: four qualitative, three mixed methods and 22 quantitative studies. A total of 291,012 patients were represented. Successful care transition was enhanced by access to insurance, ease of payment methods, effective communication, prior booked primary care provider appointments and access to transportation. Many patients experienced financial toxicity, and the shortfall between fees charged and rebates provided was found to influence primary care provider follow‐up compliance.ConclusionFuture recommendations to provide safe and effective transitions of care would be to optimise supported self‐management for patients and deliver timely and clear communication with standardised discharge documentation to be shared between the emergency department and primary care providers.Relevance for Clinical PracticeThere is no one‐size‐fits‐all approach to delivering safe care transitions between emergency department and primary care providers, and future research should target high‐risk groups.Trial RegistrationProspero: CRD42022316165
The Relationship Between Individual Social Responsibility and the Public's Intention to Act Violently Toward Nurses—A Cross‐Sectional Study
Authors: David Efrat , Lifshitz Mor , Kraitenbrg Kim , Warshawski Sigalit 
Published: September 2024

ABSTRACTAimsTo explore (a) the associations between individual social responsibility and the public intention to use violence against nurses; and (b) the relationship between individual social responsibility, personal variables and the public's intention to employ violence against nurses.BackgroundWorkplace violence against nurses is a significant widespread occupational health issue. To date, no reference has been found to the association between personality traits such as individual social responsibility and the public's intention to use violence against nurses.Design and MethodsA cross‐sectional survey design with a convenience sample of 667 Israeli participants from among the public. A structured self‐report questionnaire was distributed, including socioeconomic variables, individual social responsibility and responses to four vignettes describing incidents of violence directed at nurses. Multiple linear regressions were calculated for intention to employ violence, with demographic variables and individual social responsibility as independent variables. The STROBE checklist for cross‐sectional studies was used for reporting.ResultsNegative correlations were found between individual social responsibility and the intention to employ violence against nurses. Gender, having witnessed physical violence and individual social responsibility explained 19% of the variance in the intention to employ violence against nurses. Demographic variables and having witnessed verbal or physical violence were found to moderate the association between individual social responsibility and the intention to employ violence against nurses.ConclusionsWitnessing a violent incident in a healthcare setting is a risk factor for the intention to employ violence against nurses. Our findings point to the role of individual social responsibility as one of the strategies to help reduce violent events.Implications for the Profession and/or Patient CareEducating and promoting values of social responsibility among the public can reduce incidents of violence in healthcare settings, thus contributing to the safety and quality of care provided.Patient or Public ContributionThe public contributed via study participation.
Estrogen‐dependent oxytocin expression in the hypothalamus and estrogen‐dependent vasopressin in the median eminence
Authors: Nishimura Kazuaki , Ueta Yoichi , Yoshino Kiyoshi 
Published: September 2024

AbstractThe posterior pituitary (PP) hormones oxytocin (OXT) and arginine vasopressin (AVP) are synthesized within the hypothalamic nucleus and released from the PP into systemic circulation. Hypothalamic AVP projects its axons into the external layer of median eminence (eME) and regulates anterior pituitary hormone secretion during stress responses. Although similar as PP hormones, we demonstrate distinct regulatory roles of estrogen in hypothalamic OXT and AVP dynamics. OXT dynamics in the hypothalamus exhibit sex‐dependent variations and that estrogen may influence dynamic OXT level changes, as observed in OXT‐mRFP1 transgenic rats. Estrogen was also observed to modulate dynamic changes in AVP levels in the axon terminals of eME in female AVP‐eGFP transgenic rats. Although OXT and AVP are produced within the similar hypothalamic region, both exhibit distinct dynamics within the hypothalamus. Estrogen acts on the hypothalamus, and further effects of estrogen replacement therapy can be expected.
Correlation Between Temporomandibular Joint Disc Perforation and Degenerative Joint Changes: A CBCT and Clinical Analysis
Authors: Yang Rong , Lee Lee Mui , Zhu YaoMin , Jia Wen Yuan , Yao Wei , Yu Yue , Wu Shu Jun 
Published: September 2024

ABSTRACTObjectivesTo analyse the correlation between temporomandibular joint (TMJ) disc perforation and degenerative joint changes (DJC) on cone‐beam computed tomography (CBCT) and related factors.Study DesignA total of 238 female patients with anterior disc displacement without reduction (ADDwoR), accounting for 348 affected joints, requiring TMJ disc open anchorage surgery were included in the study conducted from June 2021 to August 2022. Following TMJ disc open anchorage surgery, patients were divided into two groups: disc perforation (DP) and disc non‐perforation (DNP). CBCT was utilised to assess different grades of condyle and articular eminence degenerative changes, and comparisons were made between the two groups regarding DJC and clinically relevant factors.ResultsIn comparison with the DNP group, the DP group exhibited statistically significant differences in mid‐ and late‐stage condyle bone degenerative changes and bone alterations of the articular eminence (odds ratio [OR] = 7.822; 95% CI [4.438–13.785]; p < 0.001 and OR = 5.575; 95% CI [3.128–9.936]; p < 0.001). Additionally, persistent joint sounds (OR = 1.932; 95% CI [1.011–3.691]; p = 0.046) and longer disease duration (OR = 4.901; 95% CI [2.395–10.028]; p < 0.001) demonstrated statistically significant differences. However, no significant differences were observed between the two groups in terms of age, joint pain and limited mouth opening.ConclusionsBone degeneration changes in TMJ CBCT images are a high possible risk factor for DP. With an escalation in the degree of condyle degeneration, the risk of DP may increased correspondingly. Persistent joint sounds and extended duration of the disease were also confirmed to be noteworthy clinical risks of DP.
Identification of Pathogenic Fungi Causing Postharvest Disease of Banana Fruit (Musa acuminata Cavendish Subgroup) in Ho Chi Minh City, Vietnam
Authors: Nguyen Quoc‐Duy , Dang Duy Hung , Nguyen Ngoc Thanh Tuyen , Pham Quoc Dang , Nguyen Vinh Lam , Do Anh Duy 
Published: September 2024

ABSTRACTBanana (Musa acuminata Cavendish Subgroup) cultivation plays a pivotal role in Vietnam's economy. However, the presence of postharvest diseases poses significant challenges as they adversely affect the quality and market value of the crop. The objective of this study was to identify the microbial strains responsible for these diseases through phylogenetic analysis and morphological characterisation. Four fungal isolates including Colletotrichum musae, C. gloeosporioides, Fusarium musae and Lasiodiplodia theobromae were identified as the primary causal agents of fruit rot in postharvest bananas. Re‐infection tests, which were conducted following Koch's postulates on banana samples, confirmed the isolates' significant pathogenicity, leading to weight loss, colour alteration, firmness reduction and acidity changes in the fungal‐infected bananas. These findings hold profound implications for enhancing our understanding of banana diseases in the postharvest stage, which can contribute to the development of effective control measures and mitigation strategies in the future.
Can computerized intraosseous anaesthesia replaces the inferior alveolar nerve block in children? A randomized controlled clinical trial
Authors: Alkhouli Muaaz , Al‐Nerabieah Zuhair , Dashash Mayssoon 
Published: September 2024

AbstractObjectivesThis study aimed to compare the efficacy of computerized intraosseous anaesthesia (CIOA) administered through the QuickSleeper 5™ system with conventional inferior alveolar nerve block (IANB) in paediatric dental patients. The primary objective was to assess pain perception, efficacy, anaesthesia onset time and duration of anaesthesia between the two techniques.Materials and MethodsA total of 52 paediatric participants were enrolled in this study. Using a split‐mouth design, each child received CIOA on one side and IANB on the other to perform pulpotomy for lower primary second molars. Pain perception was measured by the Face, Legs, Activity, Cry, and Consolability (FLACC) scale. Efficacy of anaesthesia was measured by FLACC scale during the pulpotomy procedure. Onset time and duration of anaesthesia for anaesthesia was recorded in minutes for both techniques.ResultsCIOA demonstrated significantly lower pain scores compared to IANB (mean pain score = 3.5, 5.75, respectively). IANB showed a success rate of 77%, whereas CIOA showed a success rate of 92%. Moreover, CIOA exhibited a faster onset of anaesthesia (the mean onset time of IANB and CIOA was 3.4 min ±1.1 and 0.2 min ±0.5, respectively). There was no significant difference regarding the duration of anaesthesia between the two techniques (p‐value >0.05).ConclusionIt was concluded that CIOA causes less pain than IANB. The success rates of both CIOA and IANB were 92% and 77%, respectively. The onset time of anaesthesia was faster in CIOA compared to IANB. However, there was no difference between the two studied techniques regarding the duration of anaesthesia.
Sub‐Acromioclavicular Decompression Increases the Risk of Postoperative Shoulder Stiffness after Arthroscopic Rotator Cuff Repair
Authors: Li Cheng , Wang Zhiling , Ali Maslah Idiris , Long Yi , Alike Ymuhanmode , Zhou Min , Cui Dedong , Zheng Zhenze , Meng Ke , Hou Jingyi , Yang Rui 
Published: September 2024

ObjectiveThe sub‐acromioclavicular (SAC) decompression is often performed during arthroscopic rotator cuff repair. However, the impact of SAC decompression on patients with postoperative shoulder stiffness (POSS) are controversial and unclear. This study is aim to evaluate the impact of additional sub‐acromioclavicular (SAC) decompression during arthroscopic rotator cuff repair on the postoperative shoulder stiffness (POSS) in patients.MethodsThis retrospective study examined digital data from patients with full‐thickness rotator cuff tears who underwent arthroscopic rotator cuff repair at a local institution. Patient‐reported outcomes were evaluated using the American Shoulder and Elbow Surgeons (ASES) Score, the University of California–Los Angeles (UCLA) score, and visual analog scale (VAS) scores. Restricted shoulder mobility occurring within 6 months postoperatively, lasting more than 12 weeks, characterized by a passive forward flexion angle of <120° or an external rotation angle of <30°, with or without associated shoulder pain was identified as POSS. Factors affecting POSS were analyzed by binary logistic regression analysis. The patient‐reported outcomes scores were analyzed by generalized estimating equations to examine the impact of SAC decompression.ResultsA total of 155 patients met the set criteria and were included in the study. The analysis of binary logistic regression showed that diabetes (p = 0.001) and SAC decompression (p = 0.003) were independent factors for POSS. In the analysis of each follow‐up point, only at the 3‐month follow‐up, the ASES scores (p = 0.003), UCLA scores (p = 0.045), and VAS scores (p = 0.005) showed significant differences between the SAC decompression group and the non‐decompression group. For the intergroup comparison, the results showed a significant difference in the ASES scores (β = −4.971, p = 0.008), UCLA scores (β = −1.524, p = 0.019), and VAS scores (β = 0.654, p = 0.010) throughout the study duration between the SAC decompression group and the non‐decompression group.ConclusionThe findings of this study suggested that SAC decompression during arthroscopic rotator cuff repair increase the risk of POSS compared with those without the decompression, which indicate surgeons do not perform SAC decompression unless necessary.
Artificial Intelligence‐Guided Assessment of Femoral Neck Fractures in Radiographs: A Systematic Review and Multilevel Meta‐Analysis
Authors: Ramadanov Nikolai , Lettner Jonathan , Hable Robert , Hakam Hassan Tarek , Prill Robert , Dimitrov Dobromir , Becker Roland , Schreyer Andreas G. , Salzmann Mikhail 
Published: September 2024

Artificial Intelligence (AI) is a dynamic area of computer science that is constantly expanding its practical benefits in various fields. The aim of this study was to analyze AI‐guided radiological assessment of femoral neck fractures by performing a systematic review and multilevel meta‐analysis of primary studies. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) on May 21, 2024 [CRD42024541055]. The updated Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines were strictly followed. A systematic literature search of PubMed, Web of Science, Ovid (Med), and Epistemonikos databases was conducted until May 31, 2024. Critical appraisal using the Quality Assessment of Diagnostic Accuracy Studies‐2 (QUADAS‐2) tool showed that the overall quality of the included studies was moderate. In addition, publication bias was presented in funnel plots. A frequentist multilevel meta‐analysis was performed using a random effects model with inverse variance and restricted maximum likelihood heterogeneity estimator with Hartung‐Knapp adjustment. The accuracy between AI‐based and human assessment of femoral neck fractures, sensitivity and specificity with 95% confidence intervals (CIs) were calculated. Study heterogeneity was assessed using the Higgins test I2 (low heterogeneity <25%, moderate heterogeneity: 25%–75%, and high heterogeneity >75%). Finally, 11 studies with a total of 21,163 radiographs were included for meta‐analysis. The results of the study quality assessment using the QUADAS‐2 tool are presented in Table 2. The funnel plots indicated a moderate publication bias. The AI showed excellent accuracy in assessment of femoral neck fractures (Accuracy = 0.91, 95% CI 0.83 to 0.96; I2 = 99%; p < 0.01). The AI showed good sensitivity in assessment of femoral neck fractures (Sensitivity = 0.87, 95% CI 0.77 to 0.93; I2 = 98%; p < 0.01). The AI showed excellent specificity in assessment of femoral neck fractures (Specificity = 0.91, 95% CI 0.77 to 0.97; I2 = 97%; p < 0.01). AI‐guided radiological assessment of femoral neck fractures showed excellent accuracy and specificity as well as good sensitivity. The use of AI as a faster and more reliable assessment tool and as an aid in radiological routine seems justified.
When and how do people share? Attachment anxiety predicts support‐seeking strategies
Authors: Snyder Matthew D. , Sun Elina R. , Nie Jiaxuan , Jakubiak Brett K. 
Published: September 2024

AbstractAttachment anxiety is expected to motivate people to seek excessive attention, reassurance, and help from their attachment figures. However, prior studies assessing links between attachment anxiety and this hyperactivating support‐seeking strategy have yielded inconsistent results. To advance this literature, the current research focused on the disclosure of negative personal experiences (i.e., disclosure decisions and disclosure strategies), an overlooked step in the support‐seeking process where hyperactivation may occur. Participants (N = 444) reported whether and how they shared up to four recent negative events with up to three attachment figures, and they reported their relationship‐specific attachment toward each figure (to improve measurement precision). Participants were more likely to report sharing negative events with attachment figures to whom they reported greater attachment anxiety, especially when they also perceived low responsiveness in that relationship. Additionally, participants reported that they displayed greater distress, downplayed their personal responsibility more, and emphasized a need for help more when disclosing negative events in relationships with greater attachment anxiety (behaviors that facilitate support receipt and decrease the risk of rejection). This study helps to clarify links between attachment anxiety and support seeking and provides one of the first empirical demonstrations of strategic support seeking in anxiously attached relationships.
Tetraspanin32 (TSPAN32) is downregulated in rheumatoid arthritis: Evidence from animal models and patients
Authors: Mangano Katia , Munoz‐Valle Jose’ Francisco , Palafox‐Sánchez Claudia Azucena , Petralia Maria Cristina , Leone Gian Marco , Fagone Paolo , Nicoletti Ferdinando 
Published: September 2024

AbstractThis study aimed to investigate the role of TSPAN32, a member of the tetraspanin family, in rheumatoid arthritis (RA). The objective was to assess the expression levels of TSPAN32 in experimental RA models and in RA patient immune cells, exploring its potential as a regulatory factor in RA pathogenesis. The study employed adjuvant‐induced arthritis in rats and collagen‐induced arthritis (CIA) in mice as experimental models. Ex vivo analyses included evaluating TSPAN32 expression in immune cells at different stages of the disease. In silico data analysis involved examining transcriptomic datasets from drug‐naïve and treated RA patients to correlate TSPAN32 expression with clinical parameters. TSPAN32 overexpression experiments in splenocytes from CIA mice aimed to demonstrate its functional impact on antigen‐specific immune responses. The animal models revealed a significant downregulation of TSPAN32, particularly in synovial‐infiltrating T cells. Also, TSPAN32 overexpression inhibited pro‐inflammatory cytokine production in splenocytes. In RA patients, TSPAN32 was consistently downregulated in circulating and synovial‐infiltrating T cells, as well as in CD8+ T cells, B cells and NK cells. Drug treatment did not significantly alter TSPAN32 levels. Negative correlations were observed between TSPAN32 expression and inflammatory markers (CRP, ESR) and clinical scores (SDAI) in RA patients. This study suggests that reduced TSPAN32 expression characterizes pathogenic T‐cell populations in RA, highlighting its potential as biomarker for inflammation and disease activity. TSPAN32 may play a crucial role in shaping adaptive immune responses in RA, opening avenues for novel therapeutic strategies targeting this tetraspanin family member.
Which allogeneic hematopoietic cell transplant recipients have an increased risk for delayed‐onset clinically significant cytomegalovirus infection after letermovir prophylaxis?
Authors: Mendoza Maria Alejandra , Bhaimia Eric , Alkhateeb Hassan B. , Razonable Raymund R. , Thoendel Matthew 
Published: September 2024

AbstractIntroductionCytomegalovirus (CMV) reactivation is one of the most common complications after allogeneic hematopoietic stem cell transplantation (HSCT). Letermovir is approved for CMV prophylaxis among high‐risk recipients. However, delayed‐onset post‐prophylaxis clinically significant CMV infection (csCMVi) has been observed, suggesting the potential for extending letermovir prophylaxis beyond the first one hundred days post‐HSCT.MethodsRetrospective multicenter cohort study of allogeneic HSCT patients from August 2018 to March 2023. The primary aim of this study was to identify the risk factors at day 100 associated with delayed onset csCMVi, in patients who received letermovir prophylaxis up to day 100. Competing risk analysis was used to evaluate incidence with specific risk factors, using Gray's Test comparing groups for each event.ResultsAmong 166 eligible allogeneic HSCT recipients, the most common primary hematological diagnosis was acute myelogenous leukemia (AML) (42.2%). Twenty‐six (15.7%) developed a breakthrough csCMVi. Delayed‐onset csCMVi occurred in 23.5%, at a median time of 133 days after SCT. On multivariate analysis, having a matched unrelated donor (odds ratio [OR] 2.46) and a CMV donor negative/recipient positive status (OR 3.47) were associated with delayed onset csCMVi. In contrast, AML had a lower odd of having delayed‐onset csCMVi (OR 0.23).ConclusionsHaving a matched unrelated donor, a CMV donor negative/recipient positive status, and a non‐AML underlying disease were associated with delayed onset csCMVi. Prospective studies are needed to evaluate whether extended letermovir prophylaxis is beneficial for these patients.
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Efficacy and safety of a preventive strategy against tuberculosis in liver transplantation recipients including the treatment of latent infection with moxifloxacin
Authors: Fayos Marina , Silva Jose Tiago , Fernández‐Ruiz Mario , Ruiz‐Merlo Tamara , Visentin Alessandro , Loinaz Carmelo , Manrique‐Municio Alejandro , Caso José María , González‐Olmedo Jesús , Rodríguez‐Góncer Isabel , López‐Medrano Francisco , Lumbreras Carlos , Aguado José María , San‐Juan Rafael 
Published: September 2024

AbstractBackgroundPreventive management of tuberculosis in liver transplantation (LT) is challenging due to difficulties in detecting and treating latent tuberculosis infection (LTBI). The aim of this study was to analyze the safety and efficacy of a screening strategy for LTBI with the inclusion of moxifloxacin as treatment.MethodsWe performed a retrospective single‐center study of all LTs performed between 2016 and 2019 with a minimum 4‐year follow‐up and a standardized protocol for the evaluation of LTBI.ResultsPretransplant LTBI screening was performed in 191/218 (87.6%) patients, and LTBI was diagnosed in 27.2% of them. Treatment for LTBI was administered to 71.2% of the patients and included moxifloxacin in 75.6% of the cases. After a median follow‐up of 1628 days, no cases of active tuberculosis occurred among moxifloxacin‐treated patients. The incidence of Clostridioides difficile (0.46 vs. 0.38 episodes/1000 transplant‐days; p = .8) and multidrug‐resistant gram‐negative bacilli infection (0 vs. 0.7 episodes per 1000 transplant‐days; p = .08) were not significantly higher in comparison to patients who did not receive moxifloxacin.ConclusionA preventive strategy based on systematic LTBI screening and moxifloxacin treatment before LT in positive cases appears safe and effective in preventing the development of tuberculosis in LT recipients. However, our findings are limited by a small sample size; thus, larger studies are required to validate our observations.
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