bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Publication Trends of Retinopathy of Prematurity Literature Over 40 Years
Authors: Vakharia Paras P. , Huang Natalie T. , Jankowski Michelle , Thomas Benjamin J. , Chan R. V. Paul , Drenser Kimberly A. , Trese Michael T. , Capone Antonio , Yonekawa Yoshihiro 
Published: August 2017

Purpose: The purpose of this study was to conduct a bibliometric analysis to evaluate the publication trends of retinopathy of prematurity (ROP) literature over time, focusing on geographic and economic origins. Methods: A search for indexed English abstracts was performed in PubMed using search terms “retinopathy of prematurity” or “retrolental fibroplasia” from 1976 to 2015 and divided into 4 decades. Original research articles involving humans were included. Countries were grouped into high-, middle-, and low-income groups using World Bank criteria, and impact factors (IFs) were gathered from 2014 Thomson Reuters Journal Citation Reports. Results: A total of 5425 publications were identified, of which 2045 met the inclusion criteria. The ratios of publications per decade increased over time: 1976 to 1985 (5.4%), 1986 to 1995 (15.8%), 1996 to 2005 (25%), 2006 to 2015 (53.7%; Pearson r = .93, 95% confidence interval: 0.87-0.96). The rates of publications by income group were high—(82.2%), middle—(17.7%), and low—(0.1%). Respective mean (standard deviation) IFs by income group were 2.79 (4.87), 1.23 (1.17), and 0.42 (0.45). Top producing countries were the United States (37%), the United Kingdom (6.7%), India (4.6%), Japan (3.9%), and Turkey (3.5%). There was a significant difference between the time distribution of publications between high- and middle-income groups, where the latter has produced increasing publications in recent years ( P < .001), but in journals with lower IFs overall ( P < .001). Conclusions: Publications regarding ROP are increasing in number. Investigators from middle-income countries are increasingly contributing to the ROP literature but, overall, may not be recognized yet in journals with high IFs.
Cancer-associated pathways and biomarkers of venous thrombosis
Authors: Hisada Yohei , Mackman Nigel 
Published: August 2017

Abstract
Cancer patients have an increased risk of venous thromboembolism (VTE). In this review, we summarize common and cancer type–specific pathways of VTE in cancer patients. Increased levels of leukocytes, platelets, and tissue factor–positive (TF+) microvesicles (MVs) are all potential factors that alone or in combination increase cancer-associated thrombosis. Patients with lung or colorectal cancer often exhibit leukocytosis. Neutrophils could increase VTE in cancer patients by releasing neutrophil extracellular traps whereas monocytes may express TF. Thrombocytosis is often observed in gastrointestinal, lung, breast, and ovarian cancer and this could decrease the threshold required for VTE. Soluble P-selectin has been identified as a biomarker of cancer-associated thrombosis in a general cancer population and may reflect activation of the endothelium. P-selectin expression by the endothelium may enhance VTE by increasing the recruitment of leukocytes. Studies in patients with pancreatic or brain cancer suggest that elevated levels of PAI-1 may contribute to VTE. Although elevated levels of TF+ MVs have been observed in patients with different types of cancer, an association between TF+ MVs and VTE has been observed only in pancreatic cancer. Podoplanin expression is associated with VTE in patients with brain cancer and may activate platelets. Future studies should measure multiple biomarkers in each cancer type to determine whether combinations of biomarkers can be used as predictors of VTE. A better understanding of the pathways that increase VTE in cancer patients may lead to the development of new therapies to reduce the morbidity and mortality associated with thrombosis.
Delineation of the timing of second-line therapy post–autologous stem cell transplant in patients with AL amyloidosis
Authors: Hwa Yi L. , Warsame Rahma , Gertz Morie A. , Buadi Francis K. , Lacy Martha Q. , Kumar Shaji K. , Dingli David , Zeldenrust Steve R. , Leung Nelson , Hayman Susanne R. , Kapoor Prashant , Gonsalves Wilson I. , Kourelis Taxiarchis V. , Russell Stephen , Go Ronald S. , Hobbs Miriam A. , Fonder Amie L. , Rajkumar S. Vincent , Dispenzieri Angela 
Published: August 2017

Key Points
Organ progression at second-line therapy predicated inferior survival. Patients relapsing from >VGPR had a longer time to develop organ progression.
Fatigue in the general population- associations to age, sex, socioeconomic status, physical activity, sitting time and self-rated health: the northern Sweden MONICA study 2014
Authors: Engberg Isak , Segerstedt Johan , Waller Göran , Wennberg Patrik , Eliasson Mats 
Published: August 2017

Abstract
Background
Fatigue is widespread in the population and a common complaint in primary care. Little is known about prevalence of fatigue in the population and its predictors.
We aimed to describe the pattern of fatigue in the general population and to explore the associations with age, sex, socioeconomic status, self-reported physical activity, sitting time and self-rated health.

Methods
One thousand, five hundred and fifty-seven out of 2500 invited subjects in the Northern Sweden MONICA Study 2014, aged 25–74 years, filled out the Multidimensional Fatigue Inventory (MFI-20), consisting of four subscales: General fatigue (GF), Physical fatigue (PF), Reduced activity (RA) and Mental fatigue (MF). Questions regarding age, sex, socioeconomic status, physical activity, sitting time and self-rated health were also included.

Results
Higher age correlated significantly with lower fatigue scores for the GF and MF subscales. Women had higher fatigue scores than men on all subscales (p < 0.05). Among men, higher socioeconomic status was related to lower fatigue for the GF, PF and RA subscales (age adjusted p < 0.05). Among women, higher socioeconomic status was related to lower fatigue for the PF and MF subscales (age adjusted p < 0.05). Higher physical activity was connected to lower levels of fatigue for all subscales (age and sex adjusted p < 0.001) except for MF. Longer time spent sitting was also related to more fatigue on all subscales (age and sex adjusted p < 0.005) except for MF. Better self-rated health was strongly associated with lower fatigue for all subscales (age and sex adjusted p < 0.001).

Conclusion
Older, highly educated, physically active men, with little sedentary behavior are generally the least fatigued. Self-rated health is strongly related to fatigue. Interventions increasing physical exercise and reducing sedentary behavior may be important to help patients with fatigue and should be investigated in prospective studies.
Postdiagnosis Statin Use and Mortality in Danish Patients With Prostate Cancer
Authors: Larsen Signe Benzon , Dehlendorff Christian , Skriver Charlotte , Dalton Susanne Oksbjerg , Jespersen Christina Gade , Borre Michael , Brasso Klaus , Nørgaard Mette , Johansen Christoffer , Sørensen Henrik Toft , Hallas Jesper , Friis Søren 
Published: August 2017

Purpose Increasing evidence indicates that statin use may reduce mortality from prostate cancer. In this work, we examined whether postdiagnosis statin use was associated with reduced cancer-specific mortality or all-cause mortality among patients with prostate cancer in Denmark. Material and Methods From nationwide Danish registries, we identified all patients with incident prostate adenocarcinoma from 1998 to 2011 and retrieved data on tumor and patient characteristics, drug use, and primary treatment. We defined postdiagnosis use (two or more prescriptions) of statins as a time-varying covariate with 1-year lag. Cox proportional hazards regression models used to compute hazard ratios (HRs) for prostate cancer–specific mortality and all-cause mortality through 2013 associated with postdiagnosis statin use. In secondary and sensitivity analyses, we assessed statin use within exposure periods of 1 year or 5 years after prostate cancer diagnosis and evaluated the influence of prediagnosis statin use. Results Among 31,790 patients, 7,365 died of prostate cancer and 11,811 died from other causes during a median follow-up of 2.8 years (interquartile range, 1.3 to 5.1 years) from 1 year after diagnosis. Postdiagnosis statin use was associated with adjusted HRs of 0.83 (95% CI, 0.77 to 0.89) for prostate cancer mortality and 0.81 (95% CI, 0.76 to 0.85) for all-cause mortality. Similar results were observed in 1-year and 5-year sensitivity analyses. No substantial effect measure modification was found with estimated dose or type of statin, clinical stage, Gleason score, or with prediagnosis statin use; however, patients who were diagnosed early in the study period or who underwent radical prostatectomy or endocrine therapy exhibited slightly lower HRs for prostate cancer mortality with postdiagnosis statin use than did those in the overall analyses. Conclusion Postdiagnosis statin use was associated with reduced mortality from prostate cancer; however, it remains to be established whether this association is causal.
Serum Insulin Bioassay Reflects Insulin Sensitivity and Requirements in Type 1 Diabetes
Authors: Janssen Joseph A M J L , Llauradó Gemma , Varewijck Aimee J , Groop Per-Henrik , Forsblom Carol , Fernández-Veledo Sonia , van den Dungen Elisabeth S R , Vendrell Joan , Hofland Leo J , Yki-Järvinen Hannele 
Published: August 2017

Abstract

Context
Insulin resistance could increase insulin requirements in type 1 diabetes (T1D). Current insulin immunoassays do not detect insulin analogs. Kinase insulin receptor (IR) activation (KIRA) bioassays specific for human IR isoforms A (IR-A) and B (IR-B) permit assessment of all circulating insulin bioactivity. We studied whether IR-A and IR-B KIRA assays are related to direct measures of insulin sensitivity or insulin doses in T1D.

Design
We evaluated 31 adult patients with T1D (age 45.7 ± 1.6 years, body mass index 28.8 ± 0.7 kg/m2). Serum IR-A and IR-B bioactivities were measured by KIRA bioassays. Insulin sensitivity of glucose production (Ra) was measured by the euglycemic hyperinsulinemic clamp technique in which a low insulin dose (0.4 mU/kg/min for 240 minutes) was combined with D-[3-3H] glucose infusion to measure rates of Ra and utilization and insulin action on antilipolysis from suppression of serum free fatty acids.

Results
Baseline circulating IR-A bioactivity was 53 ± 7 pmol/L, and IR-B bioactivity was 81 ± 11 pmol/L. Compared with baseline, insulin infusion significantly increased IR-A (P &lt; 0.001) and IR-B (P &lt; 0.001) bioactivities. Fasting IR-A and IR-B bioactivities were positively related to endogenous Ra (r = 0.44, P = 0.01 and r = 0.38, P &lt; 0.05). Fasting IR-A (r = 0.43, P = 0.02) and IR-B (r = 0.47, P = 0.01) bioactivities were significantly correlated with insulin requirements and glycosylated hemoglobin (IR-A: r = 0.52, P = 0.002; IR-B: r = 0.48, P = 0.006).

Conclusions
Circulating IR-A and IR-B bioactivities are associated with insulin resistance, high insulin requirements, and poor glycemic control in T1D. Measurement of IR bioactivity by KIRA assays provides a tool to assess the amount of biologically active insulin in groups of T1D patients treated with insulin analogs.
Study of oral aniracetam in C57BL/6J mice without pre-existing cognitive impairments
Authors: Reynolds Conner D. , Jefferson Taylor S. , Volquardsen Meagan , Pandian Ashvini , Smith Gregory D. , Holley Andrew J. , Lugo Joaquin N. 
Published: August 2017

Background: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. Previous studies report the drug to be effective in both human and non-human models with pre-existing cognitive dysfunction, but few studies have evaluated its efficacy in healthy subjects. A previous study performed in our laboratory found no cognitive enhancing effects of oral aniracetam administration 1-hour prior to behavioral testing in naïve C57BL/6J mice. Methods: The current study aims to further evaluate this drug by administration of aniracetam 30 minutes prior to testing in order to optimize any cognitive enhancing effects. In this study, all naïve C57BL/6J mice were tested in tasks of delayed fear conditioning, novel object recognition, rotarod, open field, elevated plus maze, and marble burying. Results: Across all tasks, animals in the treatment group failed to show enhanced learning when compared to controls. Conclusions: These results provide further evidence suggesting that aniracetam conveys no therapeutic benefit to subjects without pre-existing cognitive dysfunction.
Impact of a Safety Huddle–Based Intervention on Monitor Alarm Rates in Low‐Acuity Pediatric Intensive Care Unit Patients
Authors: Dewan Maya , Wolfe Heather , Lin Richard , Ware Eileen , Weiss Michelle , Song Lihai , MacMurchy Matthew , Davis Daniela , MSCE Christopher P. Bonafide MD 
Published: August 2017

BACKGROUNDPhysiologic monitors generate high rates of alarms in the pediatric intensive care unit (PICU), yet few are actionable.OBJECTIVETo determine the association between a huddle‐based intervention focused on reducing unnecessary alarms and the change in individual patients' alarm rates in the 24 hours after huddles.DESIGNQuasi‐experimental study with concurrent and historical controls.SETTINGA 55‐bed PICU.PARTICIPANTSThree hundred low‐acuity patients with more than 40 alarms during the 4 hours preceding a safety huddle in the PICU between April 1, 2015, and October 31, 2015.INTERVENTIONStructured safety huddle review and discussion of alarm causes and possible monitor parameter adjustments to reduce unnecessary alarms.MAIN MEASUREMENTSRate of priority alarms per 24 hours occurring for intervention patients as compared with concurrent and historical controls. Balancing measures included unexpected changes in patient acuity and code blue events.RESULTSClinicians adjusted alarm parameters in the 5 hours following the huddles in 42% of intervention patients compared with 24% of control patients (P = .002). The estimate of the effect of the intervention adjusted for age and sex compared with concurrent controls was a reduction of 116 priority alarms (95% confidence interval, 37‐194) per 24 hours (P = .004). There were no unexpected changes in patient acuity or code blue events related to the intervention.CONCLUSIONIntegrating a data‐driven monitor alarm discussion into safety huddles was a safe and effective approach to reducing alarms in low‐acuity, high‐alarm PICU patients.
Perspectives of Clinicians at Skilled Nursing Facilities on 30‐Day Hospital Readmissions: A Qualitative Study
Authors: Clark Bennett W. , Baron Katelyn , Tynan‐McKiernan Kathleen , Britton Meredith Campbell , Minges Karl E. , Chaudhry Sarwat I. 
Published: August 2017

BACKGROUNDUnplanned 30‐day hospital readmissions are an important measure of hospital quality and a focus of national regulations. Skilled nursing facilities (SNFs) play an important role in the readmission process, but few studies have examined the factors that contribute to readmissions from SNFs, leaving hospitalists and other hospital‐based clinicians with limited evidence on how to reduce SNF readmissions.OBJECTIVETo understand the perspectives of clinicians working at SNFs regarding factors contributing to readmissions.DESIGN AND PARTICIPANTSWe prospectively identified consecutive readmissions from SNFs to a single tertiary‐care hospital. Index admissions and readmissions were to the hospital's inpatient general medicine service. SNF clinicians who cared for the readmitted patients were identified and interviewed about root causes of the readmissions using a structured interview tool. Transcripts of the interviews were inductively analyzed using grounded theory methodology.RESULTSWe interviewed 28 clinicians at 15 SNFs. The interviews covered 24 patient readmissions. SNF clinicians described a range of procedural, technological, and cultural contributors to unplanned readmissions. Commonly cited causes of readmission included a lack of coordination between emergency departments and SNFs, poorly defined goals of care at the time of hospital discharge, acute illness at the time of hospital discharge, limited information sharing between a SNF and hospital, and SNF process and cultural factors.CONCLUSIONSNF clinicians identified a broad range of factors that contribute to readmissions. Addressing these factors may mitigate patients' risk of readmission from SNFs to acute care hospitals.
Measuring Up? Persistence and Change in Analysts’ Evaluative Schemas Following Technological Change
Authors: Benner Mary J. , Ranganathan Ram 
Published: August 2017

We examine shifts in how analysts assess the strategies of incumbent firms following a radical technological change. Specifically, we use an inductive study of earnings conference call transcripts and analyst reports to study how analysts’ evaluative schemas change with technological change in the wireline telecommunications industry. We find three temporal themes. At first, analysts pressure firms to reverse strategic changes that are at odds with the existing “income”-focused metrics and logic that constitute the evaluative schema. Next, schema change unfolds with the ongoing technological change, as firm performance declines when measured with traditional metrics, and as managers frame strategic changes using new “growth”-focused metrics and logic. Finally, a distinct shift in the schema is apparent as analysts’ increasing attention to growth spurs a more positive view of strategic changes that they previously opposed, a less positive view of previously supported strategies that conformed to an income logic, and the application of the growth logic even to a firm not pursuing growth-oriented strategic changes. Results from a supplementary content analysis support these results, showing a temporal shift toward “growth” words in analyst reports and conference calls. Our process model emphasizes the gradual shifts in analysts’ evaluative schemas that ultimately support firm responses to a new technology. We highlight the importance of managerial framing as firms facing technological change pursue strategic responses that initially diverge from stakeholders’ expectations, as well as the possibility that as schemas shift, actions that initially conform to analysts’ expectations may be questioned. The online appendix is available at https://doi.org/10.1287/orsc.2017.1140 .
Rancangan D-Optimal Model Gompertz dengan Maple
Authors: Widiharih Tatik , Warsito Budi 
Published: August 2017

Gompertz model is used in many areas including biological growth studies, animal and husbandry, chemistry, and agricultural. Locally D-optimal designs for Gompertz models with three parameters is investigated. We used the Generalized Equivalence Theorem of Kiefer and Wolvowitz to determine D-optimality criteria. Tchebysheff system is used to decide that the D-optimal design is minimally supported design or nonminimally supported design. The result, D-optimal design for Gompertz model is minimally supported design with uniform weight on its support.Keywords:D-optimal, Generalized Equivalence Theorem, Tchebysheff System, Minimally Supported, Uniform Weight.
KAJIAN AKTIVITAS EKONOMI LUAR NEGERI INDONESIA TERHADAP PERTUMBUHAN EKONOMI INDONESIA PERIODE 1998-2014
Authors: Hawari Ryan , Kartiasih Fitri 
Published: August 2017

Indonesia is a developing country which adopts an “open economic”. That caused Indonesia economic is strongly influenced by factors that come from outside of Indonesia. External factors in this research is referred to foreign debt, foreign direct investment, trade openness and exchange rate of rupiah with USD. The analytical method in this research used Vector Error Correction Model (VECM) which will focused on Impulse Response Function (IRF) and Forecast Error Variance Decomposition (FEVD). Based on result of IRF, exchange rate had a positive effect to economic growth, while foreign debt, foreign direct investment and trade openness had a negative effect to economic growth. Based on result of FEVD, shock on economic growth in Indonesia affected by economic growth itself (43.21%), followed by foreign debt (26.30%), trade openness (14.16%), foreign direct investment (8.29%) and exchange rate (8.04%) Keywords: economic growth, trade openness, VECM, IRF, FEVD
Unintentional Cannabis Intoxication in Toddlers
Authors: Claudet Isabelle , Mouvier Sébastien , Labadie Magali , Manin Cécile , Michard-Lenoir Anne-Pascale , Eyer Didier , Dufour Damien ,   for the Marie-Jeanne Study Group
Published: August 2017

BACKGROUND AND OBJECTIVES:
In France, cannabis consumption is illegal. The health impact of its increasing use and higher tetrahydrocannabinol (THC) concentrations is still poorly documented, particularly that of unintentional pediatric intoxications. We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (2004–2014).

METHODS:
A retrospective, national, multicenter, observational study of a pediatric cohort. All children aged &lt;6 years admitted to a tertiary-level pediatric emergency department (PED) for proven cannabis intoxication (compatible symptoms and positive toxicological screening results) during the reference period were included.

RESULTS:
Twenty-four PEDs participated in our study; 235 children were included, and 71% of the patients were 18 months old or younger. Annual admissions increased by a factor of 13. Hashish resin was the main form ingested (72%). During the study period, the evolution was characterized by a national increase in intoxications, younger intoxicated children (1.28 ± 0.4 vs 1.7 ± 0.7 years, P = .005), and more comas (n = 38) (P = .05, odds ratio 3.5 [1.02–11.8]). Compared with other intoxications, other PED admissions, and the same age population, cannabis-related admissions were greater. There was a potential link between the increased incidence of comas and increased THC concentration in resin seized in France over the period.

CONCLUSIONS:
Children are collateral victims of changing trends in cannabis use and a prevailing THC concentration. Intoxicated children are more frequent, are younger, and have intoxications that are more severe. This raises a real issue of public health.
Developing a multilingual literary magazine in an English-only policy environment
Authors: Kasula Alex Josef 
Published: August 2017

The following article discusses the development and outcomes of a multilingual literary magazine, Olowalu Review, within an English-only policy in the United States. First, there is a review of current literature surrounding the ideas of monolingual policies in the US (the context of the article) and current research of the theory of translanguaging for multilinguals and its practice thus far in English language learning classrooms (ELL). The article elaborates on the analysis of translanguaging from Kasula (2016) and how this analysis helps to promote multilingualism. Next, there is a discussion on the achievement of the initial objectives of Olowalu Review, and how this acted as a first potential step in creating a translanguaging space for multilinguals to express themselves and making change towards a more multilingual language policy.
Felső nagymetszőfogak avulsiójának kombinált ellátása
Authors: Vajda Katalin , Fekecs Gergő , Muzsek Zsófia 
Published: August 2017

Abstract: Avulsion of the permanent teeth is one of the most serious forms of traumatic dental injuries, which endangers the patients’ quality of life. Therefore, the fast and proper treatment is crucial. In this case report we will discuss the supportive and definitive functional treatment and correct rehabilitation. The traumatic force can cause complex oral and maxillofacial injuries, which comprehensive treatment constitutes a major challenge for the dentist. Here we review functional restoration of dental injuries and their definitive aesthetic solution. Orv Hetil. 2017; 158(33): 1314–1318.