bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAPK1 as an independent prognostic marker in liver cancer
Authors: Li Ling , Guo Libin , Wang Qingshui , Liu Xiaolong , Zeng Yongyi , Wen Qing , Zhang Shudong , Kwok Hang Fai , Lin Yao , Liu Jingfeng 
Published: July 2017

The death-associated protein kinase 1 (DAPK1) can act as an oncogene or a tumor suppressor gene depending on the cellular context as well as external stimuli. Our study aims to investigate the prognostic significance of DAPK1 in liver cancer in both mRNA and protein levels. The mRNA expression of DAPK1 was extracted from the Gene Expression Omnibus database in three independent liver cancer datasets while protein expression of DAPK1 was detected by immunohistochemistry in our Chinese liver cancer patient cohort. The associations between DAPK1 expression and clinical characteristics were tested. DAPK1 mRNA expression was down-regulated in liver cancer. Low levels of DAPK1 mRNA were associated with shorter survival in a liver cancer patient cohort (n = 115; p = 0.041), while negative staining of DAPK1 protein was significantly correlated with shorter time to progression (p = 0.002) and overall survival (p = 0.02). DAPK1 was an independent prognostic marker for both time to progression and overall survival by multivariate analysis. Liver cancer with the b-catenin mutation has a lower DAPK1 expression, suggesting that DAPK1 may be regulated under the b-catenin pathway. In addition, we also identified genes that are co-regulated with DAPK1. DAPK1 expression was positively correlated with IRF2, IL7R, PCOLCE and ZBTB16, and negatively correlated with SLC16A3 in both liver cancer datasets. Among these genes, PCOLCE and ZBTB16 were significantly down-regulated, while SLC16A3 was significantly upregulated in liver cancer. By using connectivity mapping of these co-regulated genes, we have identified amcinonide and sulpiride as potential small molecules that could potentially reverse DAPK1/PCOLCE/ZBTB16/SLC16A3 expression. Our study demonstrated for the first time that both DAPK1 mRNA and protein expression levels are important prognostic markers in liver cancer, and have identified genes that may contribute to DAPK1-mediated liver carcinogenesis.
Attenuation tomography of the upper mantle
Authors: Adenis Alice , Debayle Eric , Ricard Yanick 
Published: July 2017

AbstractWe present QsADR17, a global shear wave attenuation model of the upper mantle. Synthetic tests confirm that large‐scale shear attenuation anomalies are resolved in the whole upper mantle with limited vertical smearing (≤50 km). QsADR17 shows strong correlation with surface tectonics down to 200 km depth, with low attenuation beneath continents and high attenuation beneath oceans. The attenuation signal near 250 km depth is dominated by a high‐quality factor along subduction zones. Attenuating anomalies are found beneath mid‐ocean ridges down to 150 km and under most Pacific hot spots from the lithosphere down to the transition zone. The presence of broad attenuating anomalies at 150 km depth in the Pacific Ocean suggests that several thermal plumes pond in the asthenosphere. Evidence for compositional heterogeneities is found in the lithosphere at the base of cratons and in a number of active regions.
Long‐term geomagnetically induced current observations in New Zealand: Earth return corrections and geomagnetic field driver
Authors: Mac Manus Daniel H. , Rodger Craig J. , Dalzell Michael , Thomson Alan W. P. , Clilverd Mark A. , Petersen Tanja , Wolf Moritz M. , Thomson Neil R. , Divett Tim 
Published: July 2017

AbstractTranspower New Zealand Limited has measured DC currents in transformer neutrals in the New Zealand electrical network at multiple South Island locations. Near‐continuous archived DC current data exist since 2001, starting with 12 different substations and expanding from 2009 to include 17 substations. From 2001 to 2015 up to 58 individual transformers were simultaneously monitored. Primarily, the measurements were intended to monitor the impact of the high‐voltage DC system linking the North and South Islands when it is operating in “Earth return” mode. However, after correcting for Earth return operation, as described here, the New Zealand measurements provide an unusually long and spatially detailed set of geomagnetically induced current (GIC) measurements. We examine the peak GIC magnitudes observed from these observations during two large geomagnetic storms on 6 November 2001 and 2 October 2013. Currents of ~30–50 A are observed, depending on the measurement location. There are large spatial variations in the GIC observations over comparatively small distances, which likely depend upon network layout and ground conductivity. We then go on to examine the GIC in transformers throughout the South Island during more than 151 h of geomagnetic storm conditions. We compare the GIC to the various magnitude and rate of change components of the magnetic field. Our results show that there is a strong correlation between the magnitude of the GIC and the rate of change of the horizontal magnetic field (H′). This correlation is particularly clear for transformers that show large GIC current during magnetic storms.
Application of headspace solid‐phase microextraction followed by gas chromatography coupled with mass spectrometry to determine esters of carboxylic acids and other volatile compounds inDermestes maculatusandDermestes aterlipids
Authors: Cerkowniak Magdalena , Boguś Mieczysława I. , Włóka Emilia , Stepnowski Piotr , Gołębiowski Marek 
Published: July 2017

AbstractA constant problem in veterinary medicine, human healthcare, agriculture, forestry and horticulture is the large number of pests, and the lack of effective methods to combat them which cause no harm to the rest of the environment. It is recommended and desired to reduce the use of chemicals and increase the use of agents based on knowledge acquired in the fields of biology, chemistry and agrochemicals. To learn the defense mechanisms of insects we should consider not only the site of their physiological ability to protect against external factors (cuticle), but also the possibility of chemical protection, formed by all compounds on the surface and in the body of insects. In this study, a procedure was developed to determine the esters of carboxylic acids in insect lipids. Headspace solid‐phase microextraction was followed by gas chromatography coupled with gas spectrometry. First, the best conditions were selected for the analysis to obtain the best chromatographic separation. An RTx‐5 column was used for this purpose. Polydimethylsiloxane/divinylbenzene (PDMS/DVB) and polyacrylate fibers were used to isolate acid esters. PDMS/DVB fiber achieved the best conditions for the extraction; the extraction time was 50 min, the extraction temperature was 105°C and the desorption time was 10 min at 230°C. These solid‐phase microextraction conditions were used to analyze volatile compounds extracted from insects belonging to the Dermestidae family.
Does snobbish service generate better sales? The case of luxury goods
Authors: Chiou Jyh‐Shen , Hsiao Cheng‐Chieh 
Published: July 2017

AbstractThe objective of this study is to explore whether a “bad” service encounter triggers a consumer's impulse purchase in a luxury goods store in an Asian emerging market. A 2 (service encounter: favorable vs. snobbish) × 2 (shopping companion: alone vs. with a close friend) between‐group factorial design was employed with 160 female consumers in an Asian emerging market to examine the antecedents of both the urge to save social identity and the impulse purchase of luxury goods. The results show that consumers in an Asian emerging market can be triggered to make an impulse purchase of a luxury good, not because they received excellent service in the store but because they encountered snobbish service, especially when shopping with a close friend. Research implications and limitations are also discussed.
Testing the Limits of the BOPHY Platform: Preparation, Characterization, and Theoretical Modeling of BOPHYs and Organometallic BOPHYs with Electron‐Withdrawing Groups at β‐Pyrrolic and Bridging Positions
Authors: Zatsikha Yuriy V. , Nemez Dion B. , Davis Rebecca L. , Singh Simarpreet , Herbert David E. , King Alex J. , Ziegler Christopher J. , Nemykin Victor N. 
Published: July 2017

AbstractSeveral BOPHY derivatives with and without ferrocene fragments, and with electron‐withdrawing ester groups appended to the β‐pyrrolic positions have been prepared and characterized by NMR, UV/Vis near‐infrared (NIR), high‐resolution mass spectrometry, and fluorescence spectroscopy, as well as X‐ray crystallography. The redox properties of new BOPHYs were probed by electrochemical (cyclic and differential pulse voltammetry) and spectroelectrochemical methods. In an attempt to prepare BOPHY derivatives with a cyano group at the bridging position using a similar approach for BODIPY cyanation, adducts from the nucleophilic attack of the cyanide anion on the bridging position in BOPHY have been isolated and characterized by spectroscopic methods. Oxidation of such adducts, however, resulted in formation of either the starting BOPHYs, or partial extrusion of the BF2 fragment from the BOPHY core, which was confirmed by spectroscopy and X‐ray crystallography. DFT and TDDFT calculations on all target materials correlate well with the experimental data, and suggest the dramatic reduction of the nitrogen atom basicity at the hydrazine bridge of the BOPHY upon introduction of the cyano group at the bridging‐carbon atom.
Construction of All‐Solid‐State Batteries based on a Sulfur‐Graphene Composite and Li9.54Si1.74P1.44S11.7Cl0.3 Solid Electrolyte
Authors: Xu Ruochen , Wu Zhang , Zhang Shenzhao , Wang Xiuli , Xia Yan , Xia Xinhui , Huang Xiaohua , Tu Jiangping 
Published: July 2017

AbstractHerein an effective way for construction of all‐solid‐state lithium‐sulfur batteries (LSBs) with sulfur/reduced graphene oxide (rGO) and Li9.54Si1.74P1.44S11.7Cl0.3 solid electrolyte is reported. In the composite cathode, the Li9.54Si1.74P1.44S11.7Cl0.3 powder is homogeneously mixed with the S/rGO composite to enhance the ionic conductivity. Coupled with a metallic Li anode and solid electrolyte, the designed S/rGO‐Li9.54Si1.74P1.44S11.7Cl0.3 composite cathode exhibits a high specific capacity and good cycling stability. A high initial discharge capacity of 969 mAh g−1 is achieved at a current density of 80 mA g−1 at room temperature and the cell retains a reversible capacity of over 827 mAh g−1 after 60 cycles. The enhanced performance is attributed to the intimate contact between the S/rGO and Li9.54Si1.74P1.44S11.7Cl0.3 electrolyte, and high electrical conductivity of rGO and high ionic conductivity of the solid electrolyte.
Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3
Authors: Dianati Vahid , Shamloo Azar , Kwiatkowska Anna , Desjardins Roxane , Soldera Armand , Day Robert , Dory Yves L. 
Published: July 2017

AbstractPACE4, a member of the proprotein convertases (PCs) family of serine proteases, is a validated target for prostate cancer. Our group has developed a potent and selective PACE4 inhibitor: Ac‐LLLLRVKR‐NH2. In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. The resulting inhibitor is eight times more potent than the P3 Val parent inhibitor and two times more selective over furin, because the equivalent salt bridge with furin E257 is not optimal. Moreover, the β‐branched nature of the new P3 residue favors the extended β‐sheet conformation usually associated with substrates of proteases. This work provides new insight for better understanding of β‐sheet backbone–backbone interactions between serine proteases and their peptidic ligands.
ANGPTL8 (betatrophin) role in diabetes and metabolic diseases
Authors: Abu‐Farha Mohamed , Abubaker Jehad , Tuomilehto Jaakko 
Published: July 2017

SummaryDiabetes is a major disease worldwide that is reaching epidemic levels. Its increased prevalence as well as its association with a high number of complications such as cardiovascular diseases, nephropathy, and retinopathy makes it an important disease for investigation. ANGPTL8 is a recently identified hormone that has been associated with two functionally important processes in the development of type 2 diabetes, insulin resistance as well as lipid metabolism. Initial work has shown that ANGPTL8 was expressed in liver, white adipose, and brown adipose tissues. ANGPTL8 regulates the activity of lipoprotein lipase, which is a key enzyme in lipoprotein lipolysis pathway through its direct interaction with ANGPTL3. It has been also reported that it regulates the replication of β‐cells in response to insulin resistance. As a result, many recent studies have focused on the association of ANGPTL8 with diabetes and obesity as well as its association with various metabolic markers in order to better understand its physiological role in glucose homeostasis and lipid metabolism. In this review, we will highlight some of the key clinical findings, mainly from human studies, that investigated the role of ANGPTL8 in metabolic diseases such as diabetes, obesity, and the metabolic syndrome.
Contrasting outcomes of species‐ and community‐level analyses of the temporal consistency of functional composition
Authors: Katabuchi Masatoshi , Wright S. Joseph , Swenson Nathan G. , Feeley Kenneth J. , Condit Richard , Hubbell Stephen P. , Davies Stuart J. 
Published: July 2017

AbstractMultiple anthropogenic drivers affect every natural community, and there is broad interest in using functional traits to understand and predict the consequences for future biodiversity. There is, however, no consensus regarding the choice of analytical methods. We contrast species‐ and community‐level analyses of change in the functional composition for four traits related to drought tolerance using three decades of repeat censuses of trees in the 50‐ha Forest Dynamics Plot on Barro Colorado Island, Panama. Community trait distributions shifted significantly through time, which may indicate a shift toward more drought tolerant species. However, at the species level, changes in abundance were unrelated to trait values. To reconcile these seemingly contrasting results, we evaluated species‐specific contributions to the directional shifts observed at the community level. Abundance changes of just one to six of 312 species were responsible for the community‐level shifts observed for each trait. Our results demonstrate that directional changes in community‐level functional composition can result from idiosyncratic change in a few species rather than widespread community‐wide changes associated with functional traits. Future analyses of directional change in natural communities should combine community‐, species‐, and possibly individual‐level analyses to uncover relationships with function that can improve understanding and enable prediction.
The importance of species identity and interactions for multifunctionality depends on how ecosystem functions are valued
Authors: Slade Eleanor M. , Kirwan Laura , Bell Thomas , Philipson Christopher D. , Lewis Owen T. , Roslin Tomas 
Published: July 2017

AbstractStudies investigating how biodiversity affects ecosystem functioning increasingly focus on multiple functions measured simultaneously (“multifunctionality”). However, few such studies assess the role of species interactions, particularly under alternative environmental scenarios, despite interactions being key to ecosystem functioning. Here we address five questions of central importance to ecosystem multifunctionality using a terrestrial animal system. (1) Does the contribution of individual species differ for different ecosystem functions? (2) Do inter‐species interactions affect the delivery of single functions and multiple functions? (3) Does the community composition that maximizes individual functions also maximize multifunctionality? (4) Is the functional role of individual species, and the effect of interspecific interactions, modified by changing environmental conditions? (5) How do these roles and interactions change under varying scenarios where ecosystem services are weighted to reflect different societal preferences? We manipulated species’ relative abundance in dung beetle communities and measured 16 functions contributing to dung decomposition, plant productivity, nutrient recycling, reduction of greenhouse gases, and microbial activity. Using the multivariate diversity–interactions framework, we assessed how changes in species identity, composition, and interspecific interactions affected these functions in combination with an environmental driver (increased precipitation). This allowed us to identify key species and interactions across multiple functions. We then developed a desirability function approach to examine how individual species and species mixtures contribute to a desired state of overall ecosystem functioning. Species contributed unequally to individual functions, and to multifunctionality, and individual functions were maximized by different community compositions. Moreover, the species and interactions important for maintaining overall multifunctionality depended on the weight given to individual functions. Optimal multifunctionality was context‐dependent, and sensitive to the valuation of services. This combination of methodological approaches allowed us to resolve the interactions and indirect effects among species that drive ecosystem functioning, revealing how multiple aspects of biodiversity can simultaneously drive ecosystem functioning. Our results highlight the importance of a multifunctionality perspective for a complete assessment of species’ functional contributions.
Diagnosis Criterion of Abnormality of Transformer Winding by Frequency Response Analysis (FRA)
Authors: MIYAZAKI SATORU , MIZUTANI YOSHINOBU , TAGUCHI AKIRA , MURAKAMI JUNICHI , TSUJI NAOKAZU , TAKASHIMA MASAHIRO , KATO OSAMU 
Published: July 2017

SUMMARYFrequency response analysis (FRA) is a powerful technique to detect internal abnormalities within power transformers. However, diagnosis criteria of power transformers by FRA have not been fully established yet. In this paper, a new evaluation method of degree of identification between two transfer functions is proposed. In the proposed method, a frequency window is employed and cross‐correlation factor is calculated with moving the window. Furthermore, the proposed method is applied to transfer functions of real transformers with or without some abnormalities. Based on this discussion, objective criteria for diagnosis of abnormalities of transformer windings by FRA are proposed. The proposed criteria are based on a few data of transformers with some abnormalities. Therefore, the proposed criteria are tentative and they would be improved by accumulation of further data.
Prototype Evaluation of Grid‐Connected Bidirectional Power Conversion System for Storage Battery Systems with Bidirectional Switch Circuit Topology
Authors: AKAMATSU KEIJI , NORISADA TAKAAKI , YAMADA GOH , KUSAMA FUMITO , MICHIHIRA MASAKAZU 
Published: July 2017

SUMMARYIn recent years, various storage battery systems, such as home battery system, V2H/V2G system, and UPS system, have spread rapidly all over the world. We propose a new power conversion system for use in the previously‐stated storage battery systems. This paper describes operation analysis of this system for bi‐directional power conversion with fundamental grid‐interconnection. Good output follow‐up controllability characteristics of the proposed system are shown through experimental results.
Improvement of sensorial and volatile profiles of olive oil by addition of olive leaves
Authors: Malheiro Ricardo , Rodrigues Nuno , Bissaro Camila , Leimann Fernanda , Casal Susana , Ramalhosa Elsa , Pereira José Alberto 
Published: July 2017

The changes caused by the addition of olive leaves (0, 5, and 10%) during the extraction of olive oil and malaxation time (20, 30, and 30 min) in the volatile profile and sensory attributes of olive oil from cv. Cobrançosa were studied. To investigate such transformations, a central composite designs from the Response Surface Methodology (RSM) was used, retrieving 13 runs combining leaf percentages and malaxation times. Each run was extracted in triplicate (39 olive oils overall).Sensory attributes were improved to leaves addition, mainly green and fruitiness attributes in olfactory and gustatory‐olfactory sensations, but high malaxation times (>30 min) reduced pungent and bitter notes. Leaves addition increased the amounts of total volatiles, particularly the GLV's (green leaves volatiles) (E)‐2‐hexenal, (Z)‐3‐hexenal, and (Z)‐3‐hexenyl acetate, directly correlated with the improved sensory attributes. RSM models a showed positive linear effect with leaves addition, but a negative effect with malaxation time. These results suggest the use of olive leaves as effective odorants for the olive mill industry, while enabling the reduction of malaxation times and by‐product amounts.Practical applications: The results obtained clearly open new lines of research to use olive leaves, a sub‐product of olive oil extraction, in a valuable way. Olive leaves can be used as natural sources of odorants for olive oils. Furthermore, their use during the extraction of olive oils from overmature olives may also lead to an improvement of the volatile fraction and provide enhanced sensory properties to the consumers, thus conferring an added value to these oils. Another important practical application is the extraction process. In our work, we advise to optimize both the percentage of leaves and the malaxation time as much as possible, as they facilitate both sensory and volatile fractions of the extracted olive oils.Sensory attributes are improved to leaves addition, mainly green and fruitiness attributes in olfactory 17 and gustatory‐olfactory sensations, but high malaxation times (> 30 min) reduced pungent and bitter 18 notes. Leaves addition increase the amounts of total volatiles, particularly the GLV's (green leaves 19 volatiles) (E)‐2‐hexenal, (Z)‐3‐hexenal, and (Z)‐3‐hexenyl acetate, directly correlated with the improved 20 sensory attributes. RSM models a show positive linear effect with leaves addition, but a negative effect 21 with malaxation time. These results suggest the use of olive leaves as effective odorants for the olive mill 22 industry, while enabling the reduction of malaxation times and by‐product amounts.
Simultaneous Electrochemical Detection of Co(II) and Cu(II) by 1‐Diazo‐2‐Naphthol‐4‐Sulfonic Acid/MWCNTs Modified Electrode
Authors: Zamhari Muhammad , Numnuam Apon , Limbut Warakorn , Kanatharana Proespichaya , Thavarungkul Panote 
Published: July 2017

AbstractThis work describes a simple preparation of 1‐diazo‐2‐naphthol‐4‐sulfonic acid (1,2,4‐acid) and multiwalled carbon nanotubes (MWCNTs) modified glassy carbon electrode (GCE) for the simultaneous detection of Co(II) and Cu(II). MWCNTs, with their good conductivity and large surface area, were drop‐casted onto the surface of the GCE prior to the electrodeposition of 1,2,4‐acid, a metal chelating agent. Co(II) and Cu(II) were simultaneously measured by differential pulse anodic stripping voltammetry (DPASV) in a batch system. Under optimum conditions, the linear range of Co(II) was between 0.10 and 2.5 μg mL−1 with an LOD of 80 ng mL−1. Two linear ranges were obtained for Cu(II), 0.0050 to 0.030 μg mL−1 and 0.040 to 0.25 μg mL−1,with an LOD of 2.4 ng mL−1. The method offered a high operational stability for up to 52 measurements (RSD=3.4 % for Co(II) and 2.6 % for Cu(II)) and good reproducibility (RSD=1.2 % for Co(II) and 1.7 % for Cu(II)). In the simultaneous detection of Co(II) and Cu(II), there was no effect from common interferences found in wastewater. The method was successfully applied in real water samples with good recoveries (88.2±0.8 to 102.0±0.8 % for Co(II) and 96.5±0.4 to 103.8±0.9 % for Cu(II)) and the results were in good agreement with those obtained from inductively coupled plasma optical emission spectrometry (ICP‐OES) (P>0.05).