bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Changes in IL‐6 and Related Cytokines in Angiogenesis after Tibial Transverse Transplantation in Diabetic Foot Ulcers
Authors: Xu Daofei , Bai Chunxia , Hu Rong , Li Xiaoya , Guo Fudie , Zhang Dingwei , Shi Bo 
Published: September 2024

ObjectiveThe transverse tibial transfer technique is employed primarily to treat diabetic foot ulcers (DFUs), aiming to enhance leg circulation and promote new blood vessel growth. This technique is also beneficial for various conditions associated with poor blood flow in the lower extremities. However, there is no clear molecular mechanism to explain the relationship between the transverse tibial transfer technique and angiogenesis in patients with diabetic foot. This study aims to preliminarily explore the change of IL‐6 and related cytokines in promoting angiogenesis during transverse tibial transplantation, providing a direction for future research.MethodsWe retrospectively assessed a study from April 2022 to November 2023 on 76 patients with severe DFUs at Wagner stages 3–4. Flow cytometry was used to detect the levels of 12 cytokines in serum before the operation and 3, 7, 14, 21, and 35 days after the operation. Ankle‐brachial index (ABI), transcutaneous oxygen tension (TcPO2), and glycosylated hemoglobin (Hba1c) were recorded at admission and discharge. We examined the variations in cytokine levels, wound healing duration, amputation rates, infection incidence, and other key outcomes.ResultsIn our investigation, a total of 76 individuals participated, comprising 49 males and 27 females. These subjects had an average age of 64.7 years, with a standard deviation of 13 years. The mean ulcer healing time was 74 ± 31 days, amputation occurred in 3 patients, pin tract infection occurred in one patient (1.3%), and incision infection occurred in one patient (1.3%). By day 35 following the surgery, both the ABI and TcPO2 values showed a significant increase from their preoperative levels. HbA1c significantly improved compared with presurgery (p < 0.001), IL‐6 levels were significantly increased compared with presurgery (p < 0.05), and then decreased.ConclusionThe transverse tibial transfer (TTT) technique is safe and efficient for managing DFUs. The wound healing time in patients who smoke or consume alcohol is statistically significant compared with that of nonsmoking and nondrinking patients. IL‐6 exhibited substantial changes at various postoperative time points. Future research could investigate the role of IL‐6 in tibial transverse translation.
Successful utilization of topical trametinib for neurofibromatosis type I‐associated plexiform neurofibroma
Authors: Melnikov Leonid , Brichta Lars , Schloemer Nathan J. 
Published: September 2024

AbstractAn 11‐year‐old female with neurofibromatosis type 1 (NF‐1) and history of optic glioma presented with a progressive cutaneous plexiform neurofibroma of the breast. The lesion was treated with topical application of a mitogen‐activated protein kinase inhibitor, trametinib, resulting in stable, non‐progression cutaneous plexiform neurofibroma for greater than 2 years. This case demonstrates the potential application of topical trametinib for NF1‐associated superficial cutaneous plexiform neurofibroma without the toxicities associated with systemic treatment.
Newborn Filiform Periungual Hyperkeratosis: A Prospective Observational Study
Authors: Cabrera Romina , Larralde Margarita , Carvajal Jaimes Andrés , Casas Gabriel 
Published: September 2024

ABSTRACTIntroductionNewborn filiform periungual hyperkeratosis (NFPH) incidence and prevalence during the neonatal period remain unknown and have not been described in current literature. Timely diagnosis and treatment are essential to avoid complications during the neonatal period, such as acute paronychia.ObjectiveThe aim of our prospective observational study was to describe the characteristics of NFPH in neonates born in a referral hospital in Buenos Aires.ResultsOne hundred patients were included. Most of them were male (60%). NFPH consists of hard, filiform elements, mostly present bilaterally in lateral nail folds. It was found in 46% of included patients. Prevalence was higher in the right hand. Due to a trend towards easy detachment and fracture, erosions were seen in several cases. Two cases of acute paronychia secondary to NFPH were diagnosed, with favorable outcomes after topical antibiotic treatment.ConclusionThe importance of clinical examination for screening of this local predisposing factor for infection in neonatal patients is highlighted.
GhJUB1_3‐At positively regulate drought and salt stress tolerance under control of GhHB7, GhRAP2‐3 and GhRAV1 in Cotton
Authors: Ahmad Adeel , Sajjad Muhammad , Sadau Salisu Bello , Elasad Mohammad , Sun Lu , Quan Yuewei , Wu Aimin , Boying Lian , Wei Fei , Wu Hongmei , Chen Pengyun , Fu Xiaokang , Ma Liang , Wang Hantao , Wei Hengling , Yu Shuxun 
Published: September 2024

AbstractClimate change severely affects crop production. Cotton is one of the primary fiber crops in the world and its production is susceptible to various environmental stresses, especially drought and salinity. Development of stress tolerant genotypes is the only way to escape from these environmental constraints. We identified sixteen homologs of the Arabidopsis JUB1 gene in cotton. Expression of GhJUB1_3‐At was significantly induced in the temporal expression analysis of GhJUB1 genes in the roots of drought tolerant (H177) and susceptible (S9612) cotton genotypes under drought. The silencing of the GhJUB1_3‐At gene alone and together with its paralogue GhJUB1_3‐Dt reduced the drought tolerance in cotton plants. The transgenic lines exhibited tolerance to the drought and salt stress as compared to the wildtype (WT). The chlorophyll and relative water contents of wildtype decreased under drought as compared to the transgenic lines. The transgenic lines showed decreased H2O2 and increased proline levels under drought and salt stress, as compared to the WT, indicating that the transgenic lines have drought and salt stress tolerance. The expression analysis of the transgenic lines and WT revealed that GAI was upregulated in the transgenic lines in normal conditions as compared to the WT. Under drought and salt treatment, RAB18 and RD29A were strongly upregulated in the transgenic lines as compared to the WT. Conclusively, GhJUB1_3‐At is not an auto activator and it is regulated by the crosstalk of GhHB7, GhRAP2‐3 and GhRAV1. GhRAV1, a negative regulator of abiotic stress tolerance and positive regulator of leaf senescence, suppresses the expression of GhJUB1_3‐At under severe circumstances leading to plant death.
Artificial intelligence applied in human health technology assessment: a scoping review protocol
Authors: Komoda Denis Satoshi , Cardoso Marilia Mastrocolla de Almeida , Fernandes Brígida Dias , Visacri Marília Berlofa , Correa Carlos Roberto Silveira 
Published: September 2024

Objective:
This scoping review aims to map studies that applied artificial intelligence (AI) tools to perform health technology assessment tasks in human health care. The review also aims to understand specific processes in which the AI tools were applied and to comprehend the technical characteristics of these tools.

Introduction:
Health technology assessment is a complex, time-consuming, and labor-intensive endeavor. The development of automation techniques using AI has opened up new avenues for accelerating such assessments in human health settings. This could potentially aid health technology assessment researchers and decision-makers to deliver higher quality evidence.

Inclusion criteria:
This review will consider studies that assesses the use of AI tools in any process of health technology assessment in human health. However, publications in which AI is a means of clinical aid, such as diagnostics or surgery will be excluded.

Methods:
A search for relevant articles will be conducted in databases such as CINAHL (EBSCOhost), Embase (Ovid), MEDLINE (PubMed), Science Direct, Computer and Applied Sciences Complete (EBSCOhost), LILACS, Scopus, and Web of Science Core Collection. A search for gray literature will be conducted in GreyLit.Org, ProQuest Dissertations and Theses, Google Scholar, and the Google search engine. No language filters will be applied. Screening, selection, and data extraction will be performed by 2 independent reviewers. The results will be presented in graphic and tabular format, accompanied by a narrative summary.

Details of this review can be found in Open Science Framework:

osf.io/3rm8g
We Will, We Will Shock You: Adaptive Versus Conventional Functional Electrical Stimulation in Individuals Post-Stroke
Authors: Donlin Margo C. , Higginson Jill S. 
Published: September 2024

Abstract
Functional electrical stimulation (FES) is often used in poststroke gait rehabilitation to address decreased walking speed, foot drop, and decreased forward propulsion. However, not all individuals experience clinically meaningful improvements in gait function with stimulation. Previous research has developed adaptive functional electrical stimulation (AFES) systems that adjust stimulation timing and amplitude at every stride to deliver optimal stimulation. The purpose of this work was to determine the effects of a novel AFES system on functional gait outcomes and compare them to the effects of the existing FES system. Twenty-four individuals with chronic poststroke hemiparesis completed 64-min walking trials on an adaptive and fixed-speed treadmill with no stimulation, stimulation from the existing FES system, and stimulation from the AFES system. There was no significant effect of stimulation condition on walking speed, peak dorsiflexion angle, or peak propulsive force. Walking speed was significantly faster and peak propulsive force was significantly larger on the adaptive treadmill (ATM) than the fixed-speed treadmill (both p &lt; 0.0001). Dorsiflexor stimulation timing was similar between stimulation conditions, but plantarflexor stimulation timing was significantly improved with the AFES system compared to the FES system (p = 0.0059). Variability between and within subjects was substantial, and some subjects experienced clinically meaningful improvements in walking speed, peak dorsiflexion angle, and peak propulsive force. However, not all subjects experienced benefits, suggesting that further research to characterize which subjects exhibit the best instantaneous response to FES is needed to optimize poststroke gait rehabilitation using FES.
Methodology for Assessing Infant (0–2 Years) Movement Using Accelerometers: A Scoping Review
Authors: Dinkel Danae , Rech John P. , Chaudhary Priyanka , Thelagothoti Rama Krishna , Youn Jon , Ali Hesham , Schenkelberg Michaela , Knarr Brian 
Published: September 2024

Measuring infants’ (0–2 years) physical activity is a growing area of research globally. Accelerometers have been widely used to measure older children’s and adults’ physical activity. An increasing number of studies have used accelerometers as a way to measure infant physical activity, which has resulted in the application of a variety of methods. The purpose of this scoping review is to synthesize the published literature on accelerometer methodology to measure daytime physical activity among infants (0–2 years). A systematic search of five online databases using carefully selected key terms was conducted to compile relevant literature. The results of the online database searches were screened for inclusion in the scoping review. In total, 105 articles met the inclusion criteria of using accelerometers to measure infants’ physical activity. The methodologies used in the included studies were categorized by age groups: <1 month, 1–6 months, >6–12 months, >12–18 months, >18–24 months, and longitudinal (i.e., multiple measurements taken across the previously mentioned age groups). Accelerometry methodologies (e.g., wear location, number of devices, device initialization) and study design qualities (e.g., outcome of interest and location of data collection) varied widely between and within the various age groups. Accelerometer brand or type of device demonstrated greatest variation across included studies. However, ActiGraph devices to measure physical activity within free-living environments were the most common. This review provides evidence of the need for researchers to ensure the methodology used is reported in detail in order to help develop methodology that can accurately assess infant daytime movement.
Effect of Accelerometer Cut-Points on Preschoolers’ Physical Activity and Sedentary Time: A Systematic Review and Meta-Analysis
Authors: Phillips Sophie M. , Clevenger Kimberly A. , Bruijns Brianne A. , Tucker Patricia , Vanderloo Leigh M. , Loh Aidan , Naveed Manahil , Bourke Matthew 
Published: September 2024

This systematic review and meta-analysis aimed to compare estimated levels of physical activity (PA) and sedentary time (ST) of preschool-aged children (3–5 years old) based on different published accelerometer cut-points used in this age group. Four electronic databases were searched to identify studies estimating levels of PA or ST (ST, light PA [LPA], and moderate to vigorous PA [MVPA]) using multiple accelerometer cut-points, in a sample of preschool-aged children. Data were extracted and risk of bias assessed for all included studies. Random-effects meta-analysis was used to estimate pooled effects for unique combinations of accelerometer cut-points for each outcome. Twenty-four studies, reporting on 18 unique samples, were included. Results demonstrated substantial variability in estimates of PA and ST across different cut-points, with significant differences in estimates of the behaviors between most cut-points. Few cut-points showed similarity; Evenson and Pate were some of the most similar for the assessment of PA and ST of young children. However, when calculating the differences in ST, LPA, and MVPA between the cut-points, the Evenson cut-point estimates approximately 60 min more LPA per day and the Pate 148CPM cut-points estimates 23 and 37 min more ST and MVPA each day, respectively. Given that these were the most similar estimates, this highlights the magnitude of differences between the accelerometer cut-points when estimating preschool-aged children’s movement behavior. This review provides an illustration on the limitations of accelerometer cut-points used to determine PA and ST of preschool-aged children; in that they often produce substantially different estimates. This review provides a compelling rationale as to why further research moving toward alternative data processing methodologies is required, including to identify an optimal approach to estimating movement behavior outcomes in young children that considers congruence with past and future research.
Device-Based Measurement of Office-Based Physical Activity and Sedentary Time: A Systematic Review
Authors: Bongers Noah , Healy Genevieve N. , Thomas George , Clark Bronwyn K. 
Published: September 2024

Background: The aim of this study was to systematically review the findings for validity, reliability, and acceptability of device-based measures of office-based physical activity and/or sedentary time in an office context to evaluate workplace interventions. Methods: The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Analysis guidelines. Five electronic databases (PubMed, EMBASE, CINAHL, Cochrane, and Web of Science) were searched (inception to December 2023). Keywords included population (e.g., workers), type of measure (e.g., device-based), measurement constructs (e.g., validity), context (e.g., office), and behavior (e.g., sitting). Two authors screened titles, abstracts, and full texts independently with disagreements resolved by a third author. Findings were reported using narrative synthesis, and COnsensus-based standards for the Selection of health status Measurement INstruments was used for quality assessment. Results: In total, 2,299 articles were identified, with 16 articles retained. These reported 21 measurement protocols (nine in free-living settings) assessing eight worn, four remote, and one combined method. Sixteen protocols assessed office sitting, with standing (n = 8), moving (n = 11), postural transitions (n = 7), and location (n = 2) also assessed. Participant sample sizes ranged from one to 42 (median = 13). Criterion validity was assessed in all 21 protocols, with lower limb–worn measures of sitting, and worn and remote measures of location reporting the highest validity/accuracy compared with the ground truth (good to excellent). Only two articles reported acceptability (good acceptability), with none reporting reliability. Conclusions: There is evidence of valid device-based measures of office behavior (particularly sitting and location of workers), but this has largely been obtained in laboratory settings and/or with small samples. Larger studies in more varied free-living settings, potentially using multiples sources of data and assessing acceptability, are required.
Magnetically targeted lidocaine sustained-release microspheres: optimization, pharmacokinetics, and pharmacodynamic radius of effect
Authors: Zheng Ling-xi , Yu Qian , Peng Lin , Li Qiang 
Published: September 2024

ObjectiveThis study aimed to optimize the formulation of magnetically targeted lidocaine microspheres, reduce the microsphere particle size, and increase the drug loading and encapsulation rate of lidocaine. The optimized microspheres were characterized, and their pharmacokinetics and effective radii of action were studied.MethodsThe preparation of magnetically targeted lidocaine microspheres was optimized using ultrasonic emulsification-solvent evaporation. The Box-Behnken design method and response surface method were used for optimization. The optimized microspheres were characterized and tested for their in vitro release. Blood concentrations were analyzed using a non-compartment model, and the main pharmacokinetic parameters (half-life (t1/2), maximum blood concentration, area under the blood concentration-time curve (AUC), time to peak (Tmax), and mean retention time (MRT) were calculated. Pathological sections were stained to study the safety of the microsphere tissues. A rabbit sciatic nerve model was used to determine the “standard time (t0)” and effective radius of the microspheres.ResultsThe optimized lidocaine microspheres exhibited significantly reduced particle size and increased drug loading and encapsulation rates. Pharmacokinetic experiments showed that thet1/2,Tmax, and MRT of magnetically targeted lidocaine microspheres were significantly prolonged in the magnetic field, and the AUC0-48and AUC0-∞were significantly decreased. Its pharmacodynamic radius was 31.47 mm.ConclusionMagnetically targeted lidocaine microspheres provide sustained long-lasting release, neurotargeting, nerve blocking, and high tissue safety. This preparation has a significantly low blood concentration and a slow release in vivo, which can reduce local anesthetic entry into the blood. This may be a novel and effective method for improving postoperative comfort and treating chronic pain. This provides a countermeasure for exploring the size of the magnetic field for the application of magnetic drug-carrying materials.
Impact of medium anisotropy on quarkonium dissociation and regeneration
Authors: Singh Captain R. , Jamal Mohammad Yousuf , Sahoo Raghunath 
Published: September 2024

AbstractQuarkonium production in ultra-relativistic collisions plays a crucial role in probing the existence of hot QCD matter. This study explores quarkonia states dissociation and regeneration in the hot QCD medium while considering momentum anisotropy. The net quarkonia decay width ($$\Gamma _{D}$$

Γ
D

) arises from two essential processes: collisional damping and gluonic dissociation. The quarkonia regeneration includes the transition from octet to singlet states within the anisotropic medium. Our study utilizes a medium-modified potential that incorporates anisotropy via particle distribution functions. This modified potential gives rise to collisional damping for quarkonia due to the surrounding medium, as well as the transition of quarkonia from singlet to octet states due to interactions with gluons. Furthermore, we employ the detailed balance approach to investigate the regeneration of quarkonia within this medium. Our comprehensive analysis spans various temperature settings, transverse momentum values, and anisotropic strengths. Notably, we find that, in addition to medium temperatures and heavy quark transverse momentum, anisotropy significantly influences the dissociation and regeneration of various quarkonia states.
ВИКОРИСТАННЯ ПЕРІОПЕРАЦІЙНОЇ ЕПІДУРАЛЬНОЇ АНАЛГЕЗІЇ ТА РЕЗУЛЬТАТИ ХІРУРГІЧНОГО ЛІКУВАННЯ ПІСЛЯ ПАНКРЕАТОДУОДЕНЕКТОМІЇ: КЛІНІЧНЕ ДОСЛІДЖЕННЯ
Authors: УСЕНКО О. Ю. , СИМОНОВ О. М. , ГУРІН П. В. 
Published: September 2024

Мета роботи: оцінка клінічної ефективності періопераційної епідуральної аналгезії та її впливу на короткострокові післяопераційні ускладнення після панкреатодуоденектомії (ПД), враховуючи при цьому інші значущі коваріанти.
Матеріали і методи. Ретроспективний огляд було проведено з використанням проспективно зібраної бази даних послідовних пацієнтів, які перенесли ПД з січня 2022 по листопад 2023 року. Група пацієнтів складалася з 234 осіб (150 чоловіків та 84 жінки) з середнім віком 68 років. Підходи до забезпечення аналгезії були різні: у 20 пацієнтів (8 %) обмежилися виключно загальною анестезією, натомість в основній частині, 215 осіб (92 %), використали комбінований метод, що включав як епідуральну, так і загальну анестезію. Передопераційне біліарне дренування було виконано у 122 пацієнтів (52 %). Післяопераційна панкреатична нориця (ПОПН) розвинулась у 44 пацієнтів (18,8 %). Для порівняння передопераційних параметрів між групами епідуральної та загальної аналгезії використовували стандартну описову статистику. Додатково був використаний кореляційний аналіз Пірсона для вивчення зв’язків між застосуванням епідуральної аналгезії та ключовими післяопераційними показниками.
Результати. Застосування комбінованої епідуральної та загальної анестезії було пов’язане з покращенням кількох післяопераційних показників, порівняно з лише загальною анестезією. Зокрема, використання епідуральної аналгезії було пов’язане зі значно нижчою частотою виникнення клінічно значущої ПОПН, з більшістю пацієнтів (88,78 %), у яких не було жодних ознак цього ускладнення. Зокрема, використання епідуральної аналгезії було пов’язане зі значно коротшим часом до відновлення функції шлунково-кишкового тракту в групі епідуральної аналгезії (3,35 дня), порівняно з групою, що отримувала лише загальну анестезію (5,5 дня, p<0,00001). Середній артеріальний тиск був значно вищим у групі з епідуральною аналгезією (71 мм рт. ст.), порівняно з групою загальної анестезії (66 мм рт. ст., p=0,0002).Кореляційний аналіз Пірсона виявив значну зворотну кореляцію між епідуральною аналгезією та ризиком розвитку ПОПН (-0,635), а також позитивний вплив епідуральної аналгезії на швидкість відновлення функції кишечника і гемодинамічну стабільність.
Результати дослідження показують, що ширше застосування комбінації епідуральної аналгезії з загальною анестезією може стати стандартом для пацієнтів, яким виконують складні абдомінальні операції. Переваги включають прискорене відновлення функції ШКТ та зменшення частоти і тяжкості ПОПН. Однак необхідно враховувати потенційні ризики та проводити ретельний вибір анестезіологічної стратегії на основі індивідуальних характеристик пацієнта. Мультидисциплінарний підхід до планування та проведення ПД є ключовим для досягнення оптимальних результатів.