bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis
Authors: Lyu Jinhao , Ma Ning , Liebeskind David S. , Wang Danny J.J. , Ma Lin , Xu Yang , Wang Ting , Miao Zhongrong , Lou Xin 
Published: January 2016

Background and Purpose—
Three-dimensional pseudocontinuous arterial spin labeling with multiple postlabeling delays has been used to assess cerebral blood flow (CBF). We used this modality to estimate antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis.

Methods—
Consecutive patients with unilateral middle cerebral artery 50% to 99% stenosis at 2 centers underwent pseudocontinuous arterial spin labeling with a postlabeling delays of 1.5 and 2.5 s. Mean CBF of bilateral middle cerebral artery territory at the postlabeling delays 1.5 and 2.5 s was measured. Early-arriving flow proportion was defined as (CBF 1.5 s at lesion side/CBF 2.5 s at normal side)×100%. Late-arriving retrograde flow proportion was defined as ([CBF 2.5 s−CBF 1.5 s] at lesion side−[CBF 2.5 s−CBF 1.5 s] at normal side)/CBF 2.5 s at normal side×100%. Antegrade and collateral scales were evaluated in patients with conventional angiography. Spearman correlation coefficients were calculated between early-arriving flow and late-arriving retrograde flow proportions on arterial spin labeling and antegrade and collateral scales on conventional angiography, respectively.

Results—

Forty-one patients (46.0±12.0 years) were enrolled. The mean early-arriving flow proportion was 78.3±14.9%. The mean late-arriving retrograde flow proportion was 16.1±10.2%. In 21 patients with conventional angiography, Spearman correlation coefficient was 0.53 (95% confidence interval, 0.11–0.79) between antegrade grade and early-arriving flow proportion (
P
=0.01) and 0.81 (95% confidence interval, 0.56–0.92) between collateral grade and late-arriving retrograde flow proportion (
P
<0.0001).

Conclusions—
Three-dimensional pseudocontinuous arterial spin labeling with 2 postlabeling delays may provide an empirical approach for estimating antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02479243.
Impaired Higher-Level Functional Capacity as a Predictor of Stroke in Community-Dwelling Older Adults
Authors: Murakami Keiko , Tsubota-Utsugi Megumi , Satoh Michihiro , Asayama Kei , Inoue Ryusuke , Ishiguro Aya , Matsuda Ayako , Kanno Atsuhiro , Yasui Daisaku , Murakami Takahisa , Metoki Hirohito , Kikuya Masahiro , Imai Yutaka , Ohkubo Takayoshi 
Published: January 2016

Background and Purpose—
Functional capacity is a predictor, as well as a consequence, of stroke. However, little research has been done to examine whether higher-level functional capacity above basic activities of daily living is a predictor of stroke.

Methods—
We followed 1493 Japanese community-dwelling adults aged ≥60 years (mean age, 70.1 years) who were independent in basic activities of daily living and had no history of stroke. Baseline data were collected using a self-administered questionnaire. Higher-level functional capacity was measured using the total score and 3 subscales (instrumental activities of daily living, intellectual activity, and social role) derived from the Tokyo Metropolitan Institute of Gerontology Index of Competence. Adjusted hazard ratios and 95% confidence intervals were calculated by the Cox proportional hazards model.

Results—
During a mean follow-up of 10.4 years, 191 participants developed a first stroke. Impaired higher-level functional capacity based on total score of the Tokyo Metropolitan Institute of Gerontology Index of Competence was significantly associated with stroke (hazard ratio, 1.64; 95% confidence interval, 1.15–2.33). Among the 3 subscales, only intellectual activity was significantly associated with stroke (hazard ratio, 1.64; 95% confidence interval, 1.21–2.22). Social role was significantly associated with stroke only among those aged ≥75 years (hazard ratio, 1.78; 95% confidence interval, 1.07–2.98).

Conclusions—
Impaired higher-level functional capacity, especially in the domain of intellectual activity, was a predictor of stroke, even among community-dwelling older adults with independent basic activities of daily living at baseline. Monitoring of higher-level functional capacity might be useful to detect those at higher risk of developing stroke in the future.
Cardiovascular, Bleeding, and Mortality Risks of Dabigatran in Asians With Nonvalvular Atrial Fibrillation
Authors: Chan Yi-Hsin , Yen Kun-Chi , See Lai-Chu , Chang Shang-Hung , Wu Lung-Sheng , Lee Hsin-Fu , Tu Hui-Tzu , Yeh Yung-Hsin , Kuo Chi-Tai 
Published: January 2016

Background and Purpose—
Whether dabigatran is associated with different risks of cardiovascular, bleeding events, and mortality from warfarin in Asian patients with nonvalvular atrial fibrillation remains unclear.

Methods—
We used the Taiwan National Health Insurance Research Database to obtain 9940 and 9913 nonvalvular atrial fibrillation patients taking dabigatran and warfarin, respectively, from June 1, 2012, to December 31, 2013, as the dynamic cohort. Inverse probability of treatment weighting using propensity scores was used to balance covariates across 2 study groups. Patients were followed up until the first occurrence of any study outcome or end date of study.

Results—

During a median follow-up period of 0.67 years, there were 526 outcomes for dabigatran group. The hazard ratios (95% confidence intervals) comparing dabigatran with warfarin (reference) were as follows: ischemic stroke, 0.62 (0.52–0.73;
P
<0.0001); myocardial infarction, 0.67 (0.43–1.05;
P
=0.0803); intracranial hemorrhage, 0.44 (0.32–0.60;
P
<0.0001); major gastrointestinal bleeding, 0.99 (0.66–1.49;
P
=0.9658); all hospitalized major bleeding, 0.58 (0.46–0.74;
P
<0.0001); and all-cause mortality, 0.45 (0.38–0.53;
P
<0.0001). Dabigatran did not increase the risk of myocardial infarction or major gastrointestinal bleeding in all age groups when compared with warfarin. Total 8772 patients (88%) took a 110-mg dose in dabigatran group. The magnitude of effect for each outcome of 110-mg was comparable with that of 150-mg dose in the subgroup analysis.

Conclusions—
In real-world practice, dabigatran was associated with a reduced risk of ischemic stroke, intracranial hemorrhage, all hospitalized major bleeding, and all-cause mortality compared with warfarin in Asian patients with nonvalvular atrial fibrillation. Dabigatran did not increase the risk of major gastrointestinal bleeding or myocardial infarction compared with warfarin.
Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia
Authors: Liu Xiangrong , Liu Jia , Zhao Shangfeng , Zhang Haiyue , Cai Wei , Cai Mengfei , Ji Xunming , Leak Rehana K. , Gao Yanqin , Chen Jun , Hu Xiaoming 
Published: January 2016

Background and Purpose—
Interleukin-4 (IL-4) is a unique cytokine that may contribute to brain repair by regulating microglia/macrophage functions. Thus, we examined the effect of IL-4 on long-term recovery and microglia/macrophage polarization in 2 well-established stroke models.

Methods—
Transient middle cerebral artery occlusion or permanent distal middle cerebral artery occlusion was induced in wild-type and IL-4 knockout C57/BL6 mice. In a separate cohort of wild-type animals, IL-4 (60 ng/d for 7 days) or vehicle was infused into the cerebroventricle after transient middle cerebral artery occlusion. Behavioral outcomes were assessed by the Rotarod, corner, foot fault, and Morris water maze tests. Neuronal tissue loss was verified by 2 independent neuron markers. Markers of classically activated (M1) and alternatively activated (M2) microglia were assessed by real-time polymerase chain reaction, immunofluorescence, and flow cytometry.

Results—
Loss of IL-4 exacerbated sensorimotor deficits and impaired cognitive functions ≤21 days post injury. In contrast to the delayed deterioration of neurological functions, IL-4 deficiency increased neuronal tissue loss only in the acute phase (5 days) after stroke and had no impact on neuronal tissue loss 14 or 21 days post injury. Loss of IL-4 promoted expression of M1 microglia/macrophage markers and impaired expression of M2 markers at 5 and 14 days post injury. Administration of IL-4 into the ischemic brain also enhanced long-term functional recovery.

Conclusions—
The cytokine IL-4 improves long-term neurological outcomes after stroke, perhaps through M2 phenotype induction in microglia/macrophages. These results are the first to suggest that immunomodulation with IL-4 is a promising approach to promote long-term functional recovery after stroke.
The Semantics of Syntax: The Grounding of Transitive and Intransitive Constructions
Authors: van Dam Wessel O. , Desai Rutvik H. 
Published: January 2016

AbstractEmbodied theories of language maintain that brain areas associated with perception and action are also involved in the processing and representation of word meaning. A number of studies have shown that sentences with action verbs elicit activation within sensory–motor brain regions, arguing that sentence-induced mental simulations provide a means for grounding their lexical-semantic meaning. Constructionist theories argue, however, that form–meaning correspondence is present not only at the lexical level but also at the level of constructions. We investigated whether sentence-induced motor resonance is present for syntactic constructions. We measured the BOLD signal while participants read sentences with (di)transitive (caused motion) or intransitive constructions that contained either action or abstract verbs. The results showed a distinct neuronal signature for caused motion and intransitive syntactic frames. Caused motion frames activated regions associated with reaching and grasping actions, including the left anterior intraparietal sulcus and the parietal reach region. Intransitive frames activated lateral temporal regions commonly associated with abstract word processing. The left pars orbitalis showed an interaction between the syntactic frame and verb class. These findings show that sensory–motor activation elicited by sentences entails both motor resonance evoked by single words as well as at the level of syntactic constructions.
Homogenized Time Series of the Atmospheric Water Vapor Content Obtained from the GNSS Reprocessed Data
Authors: Ning T. , Wickert J. , Deng Z. , Heise S. , Dick G. , Vey S. , Schöne T. 
Published: January 2016

Abstract
The potential temporal shifts in the integrated water vapor (IWV) time series obtained from reprocessed data acquired from global navigation satellite systems (GNSS) were comprehensively investigated. A statistical test, the penalized maximal t test modified to account for first-order autoregressive noise in time series (PMTred), was used to identify the possible mean shifts (changepoints) in the time series of the difference between the GPS IWV and the IWV obtained from the European Centre for Medium-Range Weather Forecasts (ECMWF) interim reanalysis (ERA-Interim) data. The approach allows for identification of the changepoints not only in the GPS IWV time series but also in ERA-Interim. The IWV difference time series formed for 101 GPS sites were tested, where 47 of them were found to contain in total 62 changepoints. The results indicate that 45 detected changepoints were due to the inconsistencies in the GPS IWV time series, and 16 were related to ERA-Interim, while one point was left unverified. After the correction of the mean shifts for the GPS data, an improved consistency in the IWV trends is evident between nearby sites, while a better agreement is seen between the trends from the GPS and ERA-Interim data on a global scale. In addition, the IWV trends estimated for 47 GPS sites were compared to the corresponding IWV trends obtained from nearby homogenized radiosonde data. The correlation coefficient of the trends increases significantly by 38% after using the homogenized GPS data.
Assessing the Impact of Enhanced Hydrological Processes on Urban Hydrometeorology with Application to Two Cities in Contrasting Climates
Authors: Yang Jiachuan , Wang Zhi-Hua , Georgescu Matei , Chen Fei , Tewari Mukul 
Published: January 2016

AbstractTo enhance the capability of models in better characterizing the urban water cycle, physical parameterizations of urban hydrological processes have been implemented into the single-layer urban canopy model in the widely used Weather Research and Forecasting (WRF) Model. While the new model has been evaluated offline against field measurements at various cities, its performance in online settings via coupling to atmospheric dynamics requires further examination. In this study, the impact of urban hydrological processes on regional hydrometeorology of the fully integrated WRF–urban modeling system for two major cities in the United States, namely, Phoenix and Houston, is assessed. Results show that including hydrological processes improves prediction of the 2-m dewpoint temperature, an indicative measure of coupled thermal and hydrological processes. The implementation of green roof systems as an urban mitigation strategy is then tested at the annual scale. The reduction of environmental temperature and increase of humidity by green roofs indicate strong diurnal and seasonal variations and are significantly affected by geographical and climatic conditions. Comparison with offline studies reveals that land–atmosphere interactions play a crucial role in determining the effect of green roofs.
Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress
Authors: Desmarais Joelle A. , Unger Christian , Damjanov Ivan , Meuth Mark , Andrews Peter 
Published: January 2016

AbstractBackgroundHuman induced pluripotent stem (hiPS) cells have the ability to undergo self-renewal and differentiation similarly to human embryonic stem (hES) cells. We have recently shown that hES cells under replication stress fail to activate checkpoint kinase 1 (CHK1). They instead commit to apoptosis, which appears to be a primary defense mechanism against genomic instability. It is not known whether the failure of CHK1 activation and activation of apoptosis under replication stress is solely a feature of hES cells, or if it is a feature that can be extended to hiPS cells.MethodsHere we generated integration-free hiPS cell lines by mRNA transfection, and characterised the cell lines. To investigate the mechanism of S phase checkpoint activation, we have induced replication stress by adding excess thymidine to the cell culture medium, and performed DNA content analysis, apoptosis assays and immunoblottings.ResultsWe are showing that hiPS cells similarly to hES cells, fail to activate CHK1 when exposed to DNA replication inhibitors and commit to apoptosis instead. Our findings also suggest the Ataxia Telangiectasia Mutated pathway might be responding to DNA replication stress, resulting in apoptosis.ConclusionTogether, these data suggest that the apoptotic response was properly restored during reprogramming with mRNA, and that apoptosis is an important mechanism shared by hiPS and hES cells to maintain their genomic integrity when a replication stress occurs.
CELF4Variant and Anthracycline-Related Cardiomyopathy: A Children’s Oncology Group Genome-Wide Association Study
Authors: Wang Xuexia , Sun Can-Lan , Quiñones-Lombraña Adolfo , Singh Purnima , Landier Wendy , Hageman Lindsey , Mather Molly , Rotter Jerome I. , Taylor Kent D. , Chen Yii-Der Ida , Armenian Saro H. , Winick Naomi , Ginsberg Jill P. , Neglia Joseph P. , Oeffinger Kevin C. , Castellino Sharon M. , Dreyer Zoann E. , Hudson Melissa M. , Robison Leslie L. , Blanco Javier G. , Bhatia Smita 
Published: January 2016

PurposeInterindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify genetic variants that could modify cardiomyopathy risk.MethodsA genome-wide association study was conducted in childhood cancer survivors with and without cardiomyopathy (cases and controls, respectively). Single-nucleotide polymorphisms (SNPs) that surpassed a prespecified threshold for statistical significance were independently replicated. The possible mechanistic significance of validated SNP(s) was sought by using healthy heart samples.ResultsNo SNP was marginally associated with cardiomyopathy. However, SNP rs1786814 on the CELF4 gene passed the significance cutoff for gene-environment interaction (Pge= 1.14 × 10−5). Multivariable analyses adjusted for age at cancer diagnosis, sex, anthracycline dose, and chest radiation revealed that, among patients with the A allele, cardiomyopathy was infrequent and not dose related. However, among those exposed to greater than 300 mg/m2of anthracyclines, the rs1786814 GG genotype conferred a 10.2-fold (95% CI, 3.8- to 27.3-fold; P < .001) increased risk of cardiomyopathy compared with those who had GA/AA genotypes and anthracycline exposure of 300 mg/m2or less. This gene-environment interaction was successfully replicated in an independent set of anthracycline-related cardiomyopathy. CUG-BP and ETR-3-like factor proteins control developmentally regulated splicing of TNNT2, the gene that encodes for cardiac troponin T (cTnT), a biomarker of myocardial injury. Coexistence of more than one cTnT variant results in a temporally split myofilament response to calcium, which causes decreased contractility. Analysis of TNNT2 splicing variants in healthy human hearts suggested an association between the rs1786814 GG genotype and coexistence of more than one TNNT2 splicing variant (90.5% GG v 41.7% GA/AA; P = .005).ConclusionWe report a modifying effect of a polymorphism of CELF4 (rs1786814) on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants.
Measuring delirium point-prevalence in two Australian palliative care inpatient units
Authors: Hosie Annmarie , Lobb Elizabeth , Agar Meera , Davidson Patricia , Chye Richard , Lam Lawrence , Phillips Jane 
Published: January 2016

Background: Internationally, delirium prevalence in palliative care is reported to range between 26–88%, yet little is known about the occurrence of delirium in Australian palliative care inpatient populations. Aims: To: 1) ascertain 24-hour delirium point-prevalence in an Australian palliative care inpatient population; 2) test the feasibility and acceptability of the delirium measurement methodology. Methods: This was a prospective cross-sectional study. Delirium was measured in patients of two palliative care units using the Nursing Delirium Screening Scale, Memorial Delirium Assessment Scale and DSM-5 diagnostic criteria. Descriptive statistics were used to report patient demographics, palliative care phase, function, delirium measure completion, and proportion of patients with a positive screen and diagnosis. Results: Patients (n=47) had a mean age of 74 years (SD+10) and mostly malignant diagnoses (96%). All patients were screened for delirium, but few were capable of completing the Memorial Delirium Assessment Scale (n=2). One-third of patients (34%) screened positive for delirium and 19% were diagnosed as delirious according to the DSM-5. Conclusion: The Nursing Delirium Screening Scale and physician application of DSM-5 proved feasible and acceptable, while the Memorial Delirium Assessment Scale did not. Patients' advanced age and proportions screening positive for delirium and diagnosed as delirious attest to the need to rapidly recognise, assess and respond to patients experiencing this distressing disorder while being cared for in palliative care inpatient settings.
Conception of a Personalized Medication Adherence Discharge Kit for Rivaroxaban
Authors: Stern Gretchen M. , Pitlick Jamie M. , Stacy Zachary A. , Crannage Andrew J. 
Published: January 2016

Purpose Due to a lack of necessary monitoring with rivaroxaban, patients have fewer opportunities for education, adherence reinforcement, and follow-up. If rivaroxaban is taken incorrectly, patients are at increased risk for adverse events. The objective was to create personalized rivaroxaban patient adherence kits (R-PAKs) to enhance successful transition from 15 mg twice daily to 20 mg once daily on day 22 of venous thromboembolism (VTE) treatment. Summary A review of rivaroxaban drug information and existing medication adherence tools was completed to increase understanding of ways to improve adherence. Clinical pharmacists identified several concerns the R-PAK should address, including patient understanding of correct dose, administration timing, serious adverse effects, and importance of compliance, along with loss to follow-up by a health care provider. In the pilot phase, 100 R-PAKs were created. Each kit includes an educational handout describing adverse effects, administration, and monitoring; a reminder card with dosing information, date to transition, and emergency contact information; and a personalized 28-day pill organizer containing customized dividers to correlate with the first 21 days of treatment. Color-coded stickers denote the first day of starting twice-daily therapy upon discharge and the day of transition to once-daily dosing. The items were distributed in tote bags at discharge along with pharmacist education. Conclusion The R-PAKs are being used at a community teaching hospital for patients newly diagnosed with VTE who are discharged on rivaroxaban. The concept of a personalized medication box could be modified for any medication that requires high compliance or dose transitions.