bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation of Snow Initializations in NCEP Global and Regional Forecasting Models
Authors: Dawson Nicholas , Broxton Patrick , Zeng Xubin , Leuthold Michael , Barlage Michael , Holbrook Pat 
Published: April 2016

Abstract
Snow plays a major role in land–atmosphere interactions, but strong spatial heterogeneity in snow depth (SD) and snow water equivalent (SWE) makes it challenging to evaluate gridded snow quantities using in situ measurements. First, a new method is developed to upscale point measurements into gridded datasets that is superior to other tested methods. It is then utilized to generate daily SD and SWE datasets for water years 2012–14 using measurements from two networks (COOP and SNOTEL) in the United States. These datasets are used to evaluate daily SD and SWE initializations in NCEP global forecasting models (GFS and CFSv2, both on 0.5° × 0.5° grids) and regional models (NAM on 12 km × 12 km grids and RAP on 13 km × 13 km grids) across eight 2° × 2° boxes. Initialized SD from three models (GFS, CFSv2, and NAM) that utilize Air Force Weather Agency (AFWA) SD data for initialization is 77% below the area-averaged values, on average. RAP initializations, which cycle snow instead of using the AFWA SD, underestimate SD to a lesser degree. Compared with SD errors, SWE errors from GFS, CFSv2, and NAM are larger because of the application of unrealistically low and globally constant snow densities. Furthermore, the widely used daily gridded SD data produced by the Canadian Meteorological Centre (CMC) are also found to underestimate SD (similar to GFS, CFSv2, and NAM), but are worse than RAP. These results suggest an urgent need to improve SD and SWE initializations in these operational models.
A Simple Model of the Ice Shelf–Ocean Boundary Layer and Current
Authors: Jenkins Adrian 
Published: April 2016

AbstractOcean-forced basal melting has been implicated in the widespread thinning of Antarctic ice shelves, but an understanding of what determines melt rates is hampered by limited knowledge of the buoyancy- and frictionally controlled flows along the ice shelf base that regulate heat transfer from ocean to ice. In an attempt to address this deficiency, a simple model of a buoyant boundary flow, considering only the spatial dimension perpendicular to the boundary, is presented. Results indicate that two possible flow regimes exist: a weakly stratified, geostrophic cross-slope current with upslope flow within a buoyant Ekman layer or a strongly stratified, upslope current with a weak cross-slope flow. The latter regime, which is analogous to the steady solution for a katabatic wind, is most appropriate when the ice–ocean interface is steep. For the gentle slopes typical of Antarctic ice shelves, the buoyant Ekman regime, which has similarities with the case of an unstratified density current on a slope, provides some useful insight. When combined with a background flow, a range of possible near-ice current profiles emerge as a result of arrest or enhancement of the upslope Ekman transport. A simple expression for the upslope transport can be formed that is analogous to that for the wind-forced surface Ekman layer, with curvature of the ice shelf base replacing the wind stress curl in driving exchange between the Ekman layer and the geostrophic current below.
A Subkilometer-Gridlength Ensemble for Representing Stable Boundary Layer Forecast Uncertainty over Complex Terrain
Authors: Wendoloski Eric B. , Stauffer David R. , Suarez Astrid 
Published: April 2016

Abstract
An ensemble prediction system featuring subkilometer horizontal grid spacing and high vertical resolution is used to quantify forecast uncertainty in the stable boundary layer (SBL). Diversity in initial conditions and/or planetary boundary layer/surface layer physics within the WRF Model provides ensembles with up to 12 members. WRF explicit ensemble data drive trajectory calculations and the Second-Order Closure Integrated Puff (SCIPUFF) model for hazard prediction. Explicit ensemble SCIPUFF forecasts are compared to single-member SCIPUFF forecasts leveraging WRF ensemble wind field uncertainty statistics. The performance of 1.3- and 0.4-km horizontal-gridlength ensemble configurations is evaluated for two case studies of differing flow regimes with respect to the Nittany Valley in central Pennsylvania where uncertainty in atmospheric transport and dispersion (ATD) is dependent on drainage flows and circulations related to trapped lee-wave activity.
Results demonstrate that a 12-member ensemble provides reasonable spread in ATD forecasts. Additionally, single-member SCIPUFF surface-dosage probability forecasts using the meteorological ensemble statistics generally reflect the pattern while encompassing the hazard area given by the explicit SCIPUFF ensemble, but at a reduced computational cost. Low-level wind and temperature forecasts given by the 12-member, 0.4-km ensemble are improved significantly over corresponding 1.3-km ensemble forecasts. In general, the 12-member, subkilometer-gridlength ensemble configuration reliably captures temperature and wind fluctuations related to drainage flows and trapped lee-wave activity that directly impact ATD. Localized data assimilation positively impacts overall probabilistic forecast skill when trapped lee waves are present, and drainage flow case results appear more dependent on model physics than initialization strategy.
Elevation of plasma-soluble HLA-G in childhood nephrotic syndrome is associated with IgE
Authors: Liu Yanqing , Lai Meimei , Lou Yunyan , Han Qiuyue , Yang Qing , Chen Minguang , Li Jingbo , Wang Huiyan , Yan Weihua , Zheng Xiaoqun 
Published: April 2016

Background Nephrotic syndrome is related to immune system dysfunction. Soluble human leukocyte antigen-G has been suggested to have an immunomodulatory role. Additionally, human leukocyte antigen-G expression may be influenced by the 14-base pair insertion/deletion polymorphism. However, this molecule has not been investigated in nephrotic syndrome. Methods Fifty-five children with nephrotic syndrome were enrolled: 24 primary nephrotic syndrome patients and 31 recurrent nephrotic syndrome patients. A group of 120 healthy subjects were included as reference controls. Additionally, 22 patients in nephrotic syndrome remission after treatments were also included. Both nephrotic syndrome patients and healthy subjects were genotyped for the 14-base pair insertion/deletion polymorphism. Plasma soluble human leukocyte antigen-G concentrations and serum immunoglobulin concentrations were determined. Results Nephrotic syndrome patients showed significantly higher levels of both soluble human leukocyte antigen-G and immunoglobulin E compared to normal controls. Nephrotic syndrome patients presented a higher frequency of the −14-base pair allele than did normal controls. Soluble human leukocyte antigen-G concentrations in remission patients were dramatically lower compared to in nephrotic syndrome patients. Moreover, soluble human leukocyte antigen-G and immunoglobulin E were moderately correlated in nephrotic syndrome patients. Conclusions The present study demonstrated that plasma soluble human leukocyte antigen-G concentrations were significantly elevated and that a relationship between serum total immunoglobulin E in nephrotic syndrome patients and the human leukocyte antigen-G −14-base pair allele may be a risk factor for nephrotic syndrome. These findings suggest that soluble human leukocyte antigen-G may be used as a monitoring marker for nephrotic syndrome patients' condition.
Serum microRNA-135a-5p as an auxiliary diagnostic biomarker for colorectal cancer
Authors: Wang Qinjun , Zhang Hongchun , Shen Xianjuan , Ju Shaoqing 
Published: April 2016

Objective The purpose of this study was to explore serum miR-135a-5p expression in colorectal cancer and examine the potential usefulness of this molecule as a biomarker for diagnosis in colorectal cancer. Methods Serum samples were collected from 60 patients with primary colorectal cancer, 40 patients with colorectal polyps and 50 healthy controls. Serum miR-135a-5p expression levels were detected by reverse transcription quantitative real-time quantitative polymerase chain reaction. Serum carcinoembryonic antigen and carbohydrate antigen 199 concentrations were detected by MODULAR ANALYTICS E170. Results The relative expression level of serum miR-135a-5p in colorectal cancer patients, colorectal polyps patients and healthy controls was 2.451 (1.107, 4.413), 0.946 (0.401, 1.942) and 0.949 (0.194, 1.415), respectively, indicating that it was significantly higher in colorectal cancer patients than that in the other two groups ( U = 351.0, 313.0, both P < 0.001). Additionally, it was significantly correlated with different degrees of tumour differentiation ( U = 215.0, P = 0.029) and different tumour stages ( U = 202.0, P = 0.013). There was no significant correlation between the relative expression of serum miR-135a-5p and carcinoembryonic antigen ( r2 = 0.023, P = 0.293) or carbohydrate antigen 199 ( r2 = 0.067, P = 0.068) in colorectal cancer patients. Compared with colorectal polyps group, AUCROC of serum miR-135a-5p in colorectal cancer group was 0.832 with 95% CI 0.73–0.93; compared with healthy control group, AUCROC was 0.875 with 95% CI 0.80–0.95. Conclusion Serum miR-135a-5p expression in colorectal cancer patients was higher than that in patients with colorectal polyps and healthy controls, suggesting that serum miR-135a-5p may prove to be an important biomarker for auxiliary diagnosis of colorectal cancer.
Lupus pneumonitis as the initial presentation of systemic lupus erythematosus: case series from a single institution
Authors: Wan S A , Teh C L , Jobli A T 
Published: April 2016

Objective The aim of this study was to examine the clinical features, treatment and outcome of systemic lupus erythematosus (SLE) patients in our centre who presented with lupus pneumonitis as the initial manifestation. Methods We performed a retrospective review of all patients who presented with lupus pneumonitis during the initial SLE manifestation from March 2006 to March 2015. Results There were a total of five patients in our study who presented with fever and cough as the main clinical features. All patients had pulmonary infiltrates on chest radiographs. High-resolution computed tomography, which was performed in two patients, showed ground glass opacities with patchy consolidations bilaterally. All patients received high-dose steroids, 80% received intravenous cyclophosphamide and 60% received intravenous immunoglobulin. Two patients died from severe lupus pneumonitis within 2 weeks of admission despite treatment with ventilation, steroids, cyclophosphamide and intravenous immunoglobulin. Conclusions Acute lupus pneumonitis is an uncommon presentation of SLE. Mortality in this case series is 40%.
Presser – the forgotten story
Authors: Kasinathan John , Le Joey , Barker Anthony , Sharp Gillian 
Published: April 2016

Objective: Regina v Presser [1958] VR 45, is the most seminal case regarding fitness to plead for accused persons in Australia and New Zealand. It is not widely understood that Presser was a 14-year-old boy with intellectual disability. We aim to describe a clearer narrative regarding Edward John Presser. Method: Review of attainable newspaper reports framed within an historical context of fitness and relevant case law. Results: Presser’s narrative is described in greater detail than previously understood by clinicians and lawyers. Ramifications for fitness assessment are discussed including doli incapax and human rights considerations. Conclusions: The Presser criteria are widely applied; however, the case involved a 14-year-old boy with intellectual disability. Greater awareness of Presser’s narrative assists clinicians providing expert evidence regarding fitness to plead for adolescents and persons with intellectual disability.
Potential effects of high plasma to red blood cell ratio transfusion in pediatric trauma
Authors: Hwu Ruth S , Keller Martin S , Spinella Philip C , Baker David , Tao Yu , Leonard Julie C 
Published: April 2016

Objective High ratio of plasma to red blood cells during massive transfusion is associated with improved survival of traumatic injuries in adults, but this has not been demonstrated in children. Our objective was to compare the outcome of children who received high (≥1:2) versus low (<1:2) plasma: red blood cells (P:R) ratios at 24 h from injury. Methods We conducted a retrospective chart review of children <18 years of age who presented to the emergency department over a 7-year period and received massive transfusion (≥40 ml/kg red blood cells or ≥80 ml/kg total blood products in 24 h). Our primary outcome of interest was in-hospital mortality. Results We identified 38 children who received massive transfusion. There was no significant difference in in-hospital mortality (45.8% vs. 64.3%) between the high (n = 24, median ratio 1:1.1) and low P:R ratio (n = 14, median 1:3.2) groups. In subset analyses, there was reduced mortality for high P:R patients with BIG score ≥24 (69.2% vs. 100%) and those taken to the operating room within 6 h of arrival (21.4% vs. 60.0%), respectively ( p < 0.05). There was a trend for improved survival in high P:R patients without severe traumatic brain injury (TBI) (0% vs. 40.0%). Conclusions This study suggests that high P:R transfusion may improve in-hospital survival of injured children at high risk of mortality and in children without severe TBI, supporting the need for large, multi-center studies.
Canutite, NaMn3[AsO4][AsO3(OH)]2, a new protonated alluaudite-group mineral from the Torrecillas mine, Iquique Province, Chile
Authors: Kampf A. R. , Mills S. J. , Hatert F. , Nash B. P. , Dini M. , Molina Donoso A. A. 
Published: April 2016

AbstractThe new mineral canutite (IMA2013-070), NaMn3[AsO4][AsO3(OH)]2, was found at two different locations at the Torrecillas mine, Salar Grande, Iquique Province, Chile, where it occurs as a secondary alteration phase in association with anhydrite, halite, lavendulan, magnesiokoritnigite, pyrite, quartz and scorodite. Canutite is reddish brown in colour. It forms as prisms elongated on [20] and exhibiting the forms {010}, {100}, {10}, {201} and {102}, or as tablets flattened on {102} and exhibiting the forms {102} and {110}. Crystals are transparent with a vitreous lustre. The mineral has a pale tan streak, Mohs hardness of 2½, brittle tenacity, splintery fracture and two perfect cleavages, on {010} and {101}. The calculated density is 4.112 g cm−3. Optically, canutite is biaxial (+) with α = 1.712(3), β = 1.725(3) and γ = 1.756(3) (measured in white light). The measured 2V is 65.6(4)°, the dispersion is r < v (slight), the optical orientation is Z = b; X ^ a = 18° in obtuse β and pleochroism is imperceptible. The mineral is slowly soluble in cold, dilute HCl. The empirical formula (for tabular crystals from near the mineshaft), determined from electron - microprobe analyses, is (Na1.05Mn2.64Mg0.34Cu0.14Co0.03)∑4.20As3O12H1.62. Canutite is monoclinic, C2/c, a = 12.3282(4), b = 12.6039(5), c = 6.8814(5) Å, β = 113.480(8)°, V = 980.72(10) Å3 and Z = 4. The eight strongest X-ray powder diffraction lines are [dobs Å(I)(hkl)]: 6.33(34)(020), 4.12(26)(21), 3.608(29)(310,31), 3.296(57)(12), 3.150(28)(002,131), 2.819(42)(400,041,330), 2.740(100)(240,02,112) and 1.5364(31)(multiple). The structure, refined to R1 = 2.33% for 1089 Fo > 4σF reflections, shows canutite to be isostructural with protonated members of the alluaudite group.
Balićžunićite, Bi2O(SO4)2, a new fumarole mineral from La Fossa crater, Vulcano, Aeolian Islands, Italy
Authors: Pinto D. , Garavelli A. , Mitolo D. 
Published: April 2016

AbstractBalićžunićite, ideally Bi2O(SO4)2, is a new mineral found as a high-temperature fumarole sublimate (T = 600°C) at La Fossa crater, Vulcano, Aeolian Islands, Italy. It occurs as aggregates of mm-sized prismatic and elongated crystals (∼50 μm across and up to 200 μm long) associated with anglesite, leguernite, one other potentially new Bi-oxysulfate mineral, lillianite, galenobismutite, bismoclite, Cd-rich sphalerite, wurtzite, pyrite and pyrrhotite. Balićžunićite is colourless to white or pale brown, transparent and non-fluorescent. It has a vitreous lustre and a white streak. Electron microprobe analysis gives the following average chemical composition (wt.%): Bi2O3 68.68 and SO3 23.73, total 92.41. The empirical chemical formula, calculated on the basis of 9 anions p.f.u., is Bi1.99S2O9. The calculated density is 5.911 g/cm3.Balićžunićite is triclinic, space group P, with a 6.7386(3), b 11.1844(5), c 14.1754(7) Å, α 80.082(2)°, β 88.462(2)°, γ 89.517(2)°, V = 1052.01(8) Å3 and Z = 6. The six strongest reflections in the X-ray powder-diffraction data [d in Å(I) (hkl)] are: 3.146 (100) (033), 3.486 (21) (004), 3.409 (12) (01), 3.366 (7) (200), 5.562 (4) (11), 5.433 (4) (111). Balićžunićite is the natural analogue of the stable low-temperature a form of synthetic Bi2O(SO4)2. The name is in honour of Tonci Balić-Žunić(born 1952), Professor of Mineralogy at the Natural History Museum of the University of Cophenagen. Both the mineral and the mineral name have been approved by the IMA-CNMNC Commission (IMA2012-098).
A randomised, open-label study of umeclidiniumversusglycopyrronium in patients with COPD
Authors: Rheault Tara , Khindri Sanjeev , Vahdati-Bolouri Mitra , Church Alison , Fahy William A. 
Published: April 2016

This study compared the efficacy and safety of once-daily umeclidinium 62.5 µg with once-daily glycopyrronium 50 µg in patients with moderate-to-severe chronic obstructive pulmonary disease.This was a 12-week, multicentre, randomised, open-label, parallel-group study (Clinicaltrials.gov:NCT02236611). Patients were randomised 1:1 to umeclidinium 62.5 µg or glycopyrronium 50 µg administeredviaEllipta or Breezhaler dry powder inhaler, respectively. The primary endpoint was trough forced expiratory volume in 1 s (FEV1) at day 85 in the per-protocol population. Other endpoints included: weighted mean FEV1over 0–24 h and patient-reported outcomes (transition dyspnoea index score and St George's Respiratory Questionnaire total score). Adverse events were also assessed.A total of 1037 patients were randomised to treatment. Umeclidinium was non-inferior (margin: −50 mL) to glycopyrronium (trough FEV1at day 85 treatment difference: 24 mL, 95% confidence intervals: −5–54). Improvements in other endpoints were similar between treatments. Adverse event incidences were similar for umeclidinium (37%) and glycopyrronium (36%).Once-daily umeclidinium was non-inferior to once-daily glycopyrronium in patients with chronic obstructive pulmonary disease in trough FEV1at day 85. Patient-reported outcomes and safety profiles were similar for both treatments.
The hepatocyte growth factor-expressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo
Authors: Hu Shuling , Li Jinze , Xu Xiuping , Liu Airan , He Hongli , Xu Jingyuan , Chen Qihong , Liu Songqiao , Liu Ling , Qiu Haibo , Yang Yi 
Published: April 2016

Abstract
Background
Acute respiratory distress syndrome (ARDS) is a life-threatening condition in critically ill patients. Recently, we have found that mesenchymal stem cells (MSC) improved the permeability of human lung microvascular endothelial cells by secreting hepatocyte growth factor (HGF) in vitro. However, the properties and functions of MSC may change under complex circumstances in vivo. Here, we sought to determine the role of the HGF-expressing character of MSC in the therapeutic effects of MSC on ARDS in vivo.

Methods
MSC with HGF gene knockdown (MSC-ShHGF) were constructed using lentiviral transduction. The HGF mRNA and protein levels in MSC-ShHGF were detected using quantitative real-time polymerase chain reaction and Western blotting analysis, respectively. HGF levels in the MSC culture medium were measured by enzyme-linked immunosorbent assay (ELISA). Rats with ARDS induced by lipopolysaccharide received MSC infusion via the tail vein. After 1, 6, and 24 h, rats were sacrificed. MSC retention in the lung was assessed by immunohistochemical assay. The lung wet weight to body weight ratio (LWW/BW) and Evans blue dye extravasation were obtained to reflect lung permeability. The VE-cadherin was detected with inmmunofluorescence, and the lung endothelial cell apoptosis was assessed by TUNEL assay. The severity of lung injury was evaluated using histopathology. The cytokines and HGF levels in the lung were measured by ELISA.

Results
MSC-ShHGF with markedly lower HGF expression were successfully constructed. Treatment with MSC or MSC carrying green fluorescent protein (MSC-GFP) maintained HGF expression at relatively high levels in the lung at 24 h. MSC or MSC-GFP decreased the LWW/BW and the Evans Blue Dye extravasation, protected adherens junction VE-cadherin, and reduced the lung endothelial cell apoptosis. Furthermore, MSC or MSC-GFP reduced the inflammation and alleviated lung injury based on histopathology. However, HGF gene knockdown significantly decreased the HGF levels without any changes in the MSC retention in the lung, and diminished the protective effects of MSC on the injured lung, indicating the therapeutic effects of MSC on ARDS were partly associated with the HGF-expressing character of MSC.

Conclusions
MSC restores lung permeability and lung injury in part by maintaining HGF levels in the lung and the HGF-expressing character is required for MSC to protect the injured lung.
Using the Courts to Shape Medicaid Policy: Olmstead V. L.c. by Zimring and Its Community Integration Legacy
Authors: Rosenbaum Sara 
Published: April 2016

Abstract
In Olmstead v. L.C. by Zimring, the United States Supreme Court addressed the relationship between the Americans with Disabilities Act (ADA), a landmark in US civil rights law, and the Medicaid program. Olmstead holds that qualified individuals with disabilities who are protected by the ADA have the right to receive publicly funded services in community-integrated treatment settings and that medically unnecessary institutionalization violates the ADA. But the Court had to wrestle with the extent to which the ADA requires state Medicaid programs to make deep and structural reforms in how long-term care services are organized, financed, and delivered. From a strictly legal perspective, Olmstead's impact has been limited by the fact that the ADA does not require fundamental alterations in public programs. Despite this fact, Olmstead remains a watershed decision in US disability law that has helped spur transformational changes in how Medicaid addresses community-based long-term care.