bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor
Authors: Liu Zhen , Tian Yangzi , Liu Shushang , Xu Guanghui , Guo Man , Lian Xiao , Fan Daiming , Zhang Hongwei , Feng Fan 
Published: August 2016

AbstractCompared to gastric gastrointestinal stromal tumor (GIST), hepatic GIST is very rare in clinic. Reports on clinicopathological feature and prognosis of this rare disease are limited in literature. The purpose of this study was, therefore, to summarize clinical and pathological features as well as prognosis of the primary hepatic GIST. One case of primary hepatic GIST from our center and 22 cases reported in MEDLINE or China National Knowledge Infrastructure (CNKI) were enrolled into this study. Clinicopathological features as well as survival data of hepatic GIST were analyzed and compared with 297 gastric GISTs and 59 small intestinal GISTs from our center. Majority of the 22 cases (95.7%) of hepatic GIST was larger than 5 cm in size, and 75.0% of the tumors were over 5/50 HPF in mitotic index. Most of the hepatic GISTs (85.7%) displayed spindle cell shape in morphology. All of the hepatic GIST (100%) enrolled in this study were classified as high‐risk category by the National Institute of Health (NIH) risk classification. The 5‐year median disease‐free survival (DFS) time was 24.0 months and 5‐year disease‐specific survival (DSS) rate was 33.3%, respectively. Distribution of clinicopathological features was significantly different among hepatic, gastric, and small intestinal GIST. The DFS and DSS of hepatic GIST were significantly lower than those of the other two groups. Majority of the hepatic GIST is large in size and highly malignant. Prognosis of the primary hepatic GIST is worse than that of gastric GIST and small intestinal GIST.
An analysis of the relationship between metastases and cachexia in lung cancer patients
Authors: Shiono Masatoshi , Huang Kan , Downey Robert J. , Consul Nikita , Villanueva Nicolas , Beck Kristen , Fenn Kathleen , Dietz Donald , Yamaguchi Takuhiro , Kato Shunsuke , Divgi Chaitanya , Kalinsky Kevin , Wei Ying , Zhang Yuan , Borczuk Alain C. , Inoue Akira , Halmos Balazs , Acharyya Swarnali 
Published: August 2016

AbstractWeight loss and hematogenous metastases are poor prognosis factors in lung cancer patients that can but do not necessarily co‐occur. We retrospectively investigated the clinical association between cachexia, tumor characteristics (such as metastatic burden and mutational status), and treatment in lung cancer patients. The medical records of 394 lung cancer patients from two institutions (Columbia University, USA and Tohoku University, Japan) were reviewed. Information collected included the presence of cachexia, histologic subtype, tumor stage, number of metastases, mutation status, treatment, and survival. Descriptive statistics were performed. Only stage IV patients exhibited >5% weight loss (0.8%, 2.2%, 3.6%, and 5.1%, for stages I to IV; P = 0.0001). Patients with metastases developed cachexia more often than patients without metastases independent of treatment (6.0% and 7.1% weight loss in patients with metastases vs. 2.5% and 2.0% in patients without metastases, before [P = 0.0001] and after [P < 0.0001] treatment, respectively). The change in number of metastatic sites over time correlated with increasing weight loss (5.2%, 10.6%, 13.4%, and 13.4%, for an increase of 0, 1, 2, and ≥3 metastatic sites, from initial diagnosis to the endpoint; P < 0.0001). Patients with cachexia had worse survival than patients without cachexia (hazard ratio, 2.94; 95% confidence interval, 2.08–4.16; P < 0.0001). Tumors with mutated KRAS were associated with an increased risk of weight loss (11.4% weight loss in patients with mutated KRAS vs. 6.0% in patients with wild‐type KRAS; P = 0.0011). Our findings suggest that the capabilities of lung cancer to metastasize and cause cachexia might be linked intrinsically and are independent of treatments administered. KRAS‐mutated tumors were more commonly associated with cachexia.
Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in Apcmin716/+ mice
Authors: Hodgson Andrea , Wier Eric M. , Fu Kai , Sun Xin , Wan Fengyi 
Published: August 2016

AbstractAnimal models of colon cancer are widely used to understand the molecular mechanisms and pathogenesis of the disease. These animal models require a substantial investment of time and traditionally necessitate the killing of the animal to measure the tumor progression. Several in vivo imaging techniques are being used in both human clinics and preclinical studies, albeit at high cost and requiring particular expertise. Here, we report that the progression of splenomegaly coincides with and positively correlates to colon tumor development in Apcmin716/+ mice expressing a mutant gene encoding an adenomatous polyposis coli protein truncated at amino acid 716. Ultrasound image‐based spleen size measurement precisely mirrors splenomegaly development in vivo in the tumor‐laden Apcmin716/+ mice. Moreover, the spleen dimensions extracted from the ultrasound sonograms are positively correlated with normalized spleen weight and the number and area of colon tumors. Hence, we propose measuring the spleen size in vivo by ultrasound imaging as a novel approach to estimate splenomegaly development and to indirectly monitor colon tumor development in Apcmin716/+ mice. The widespread use of ultrasound machines in the laboratory setting, coupled with the fact that it is a noninvasive method, make it a straightforward and useful tool for monitoring the experimental progress of colon cancer in mice and determining end points without killing animals strictly for diagnostics purposes.
Sphingosine‐1‐phosphate‐enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells
Authors: Hashimoto Yoko , Kobayashi Mari , Matsuzaki Etsuko , Higashi Katsumasa , Takahashi‐Yanaga Fumi , Takano Aiko , Hirata Masato , Nishimura Fusanori 
Published: August 2016

AbstractIn this study, we investigated the involvement of Wnt signaling in sphingosine‐1‐phosphate (S1P)‐enhanced osteogenic differentiation of C3H10T1/2 pluripotent stem cells. We found that S1P enhanced the expression of Wnt5a and low‐density lipoprotein receptor‐related protein 5 or 6 (LRP5/6) during osteogenic differentiation. Wnt5a‐neutralizing antibody inhibited S1P‐enhanced expression of LRP5/6 and alkaline phosphatase, which are essential for osteogenic differentiation. Conversely, S1P did not affect endogenous canonical Wnt signaling. Taken together, S1P‐enhanced Wnt5a promotes LRP5/6 expression, resulting in the trigger of osteogenic differentiation of C3H10T1/2 cells. These findings suggest a potential beneficial role for S1P in bone regeneration.
Sorting out the value of spectroscopic tools to assess the Colletotrichum acutatum impact in olive cultivars with different susceptibilities
Authors: Gouvinhas Irene , Machado Nelson , Gironés‐Vilaplana Amadeo , Gomes Sónia , Carvalho Teresa , Domínguez‐Perles Raúl , Barros Ana I. R. N. A. 
Published: August 2016

The olive tree (Olea europaea L.) can be affected by Colletotrichum acutatum, causing a loss of yield and quality of the final products, whilst the incidence of this fungal infection depends on several factors, including cultivar susceptibility. Thus, the effect of C. acutatum infection in cultivars displaying different susceptibilities to this fungal disease (‘Galega Vulgar’ ‐ susceptible, ‘Cobrançosa’ ‐ moderately susceptible, ‘Picual’ ‐ tolerant) has been assessed through spectrophotometric methods and HPLC, while the FTIR spectra of the cuticles have been concomitantly registered, resorting to the ATR accessory.With the support of multivariate analysis, these spectra allowed to discriminate olives with distinct infection times, besides retrieving evidences concerning the different susceptibility of each cultivar, while these observations were reinforced by the spectrophotometric and chromatographic methods. Furthermore, the assessment of the phenolic profile evidenced individual compounds in the distinct cultivars, so as their variations in response to the fungal infection.
Synthesis and Single‐Molecule Conductance Study of Redox‐Active Ruthenium Complexes with Pyridyl and Dihydrobenzo[b]thiophene Anchoring Groups
Authors: Ozawa Hiroaki , Baghernejad Masoud , Al‐Owaedi Oday A. , Kaliginedi Veerabhadrarao , Nagashima Takumi , Ferrer Jaime , Wandlowski Thomas , García‐Suárez Víctor M. , Broekmann Peter , Lambert Colin J. , Haga Masa‐aki 
Published: August 2016

AbstractThe ancillary ligands 4′‐(4‐pyridyl)‐2,2′:6′,2′′‐terpyridine and 4′‐(2,3‐dihydrobenzo[b]thiophene)‐2,2′‐6′,2“‐terpyridine were used to synthesize two series of mono‐ and dinuclear ruthenium complexes differing in their lengths and anchoring groups. The electrochemical and single‐molecular conductance properties of these two series of ruthenium complexes were studied experimentally by means of cyclic voltammetry and the scanning tunneling microscopy‐break junction technique (STM‐BJ) and theoretically by means of density functional theory (DFT). Cyclic voltammetry data showed clear redox peaks corresponding to both the metal‐ and ligand‐related redox reactions. Single‐molecular conductance demonstrated an exponential decay of the molecular conductance with the increase in molecular length for both the series of ruthenium complexes, with decay constants of βPY=2.07±0.1 nm−1 and βBT=2.16±0.1 nm−1, respectively. The contact resistance of complexes with 2,3‐dihydrobenzo[b]thiophene (BT) anchoring groups is found to be smaller than the contact resistance of ruthenium complexes with pyridine (PY) anchors. DFT calculations support the experimental results and provided additional information on the electronic structure and charge transport properties in those metal|ruthenium complex|metal junctions.
Stereoselectivity in Autoionization Reactions of Hydrogenated Molecules by Metastable Noble Gas Atoms: The Role of Electronic Couplings
Authors: Falcinelli Stefano , Rosi Marzio , Cavalli Simonetta , Pirani Fernando , Vecchiocattivi Franco 
Published: August 2016

AbstractFocus in the present paper is on the analysis of total and partial ionization cross sections, measured in absolute value as a function of the collision energy, representative of the probability of ionic product formation in selected electronic states in Ne*−H2O, H2S, and NH3 collisions. In order to characterize the imaginary part of the optical potential, related to electronic couplings, we generalize a methodology to obtain direct information on the opacity function of these reactions. Such a methodology has been recently exploited to test the real part of the optical potential (S. Falcinelli et al., Chem. Eur. J., 2016, 22, 764–771). Depending on the balance of noncovalent contributions, the real part controls the approach of neutral reactants, the removal of ionic products, and the structure of the transition state. Strength, range, and stereoselectivity of electronic couplings, triggering these and many other reactions, are directly obtained from the present investigation.
Arene Selectivity by a Flexible Coordination Polymer Host
Authors: Wright James S. , Vitórica‐Yrezábal Iñigo J. , Thompson Stephen P. , Brammer Lee 
Published: August 2016

AbstractThe coordination polymers [Ag4(O2CCF3)4(phen)3]⋅ phen⋅arene (1⋅phen⋅arene) (phen=phenazine; arene=toluene, p‐xylene or benzene) have been synthesised from the solution phase in a series of arene solvents and crystallographically characterised. By contrast, analogous syntheses from o‐xylene and m‐xylene as the solvent yield the solvent‐free coordination polymer [Ag4(O2CCF3)4(phen)2] (2). Toluene, p‐xylene and benzene have been successfully used in mixed‐arene syntheses to template the formation of coordination polymers 1⋅phen⋅arene, which incorporate o‐ or m‐xylene. The selectivity of 1⋅phen⋅arene for the arene guests was determined, through pairwise competition experiments, to be p‐xylene>toluene≈benzene>o‐xylene>m‐xylene. The largest selectivity coefficient was determined as 14.2 for p‐xylene:m‐xylene and the smallest was 1.0 for toluene:benzene.
Highly Facet‐Dependent Photocatalytic Properties of Cu2O Crystals Established through the Formation of Au‐Decorated Cu2O Heterostructures
Authors: Yuan Guo‐Zhi , Hsia Chi‐Fu , Lin Zhen‐Wen , Chiang Chieh , Chiang Yun‐Wei , Huang Michael H. 
Published: August 2016

AbstractThis work confirms the presence of a large facet‐dependent photocatalytic activity of Cu2O crystals through sparse deposition of gold particles on Cu2O cubes, octahedra, and rhombic dodecahedra. Au‐decorated Cu2O rhombic dodecahedra and octahedra showed greatly enhanced photodegradation rates of methyl orange resulting from a better separation of the photogenerated electrons and holes, with the rhombic dodecahedra giving the best efficiency. Au–Cu2O core–shell rhombic dodecahedra also displayed a better photocatalytic activity than pristine rhombic dodecahedra. However, Au‐deposited Cu2O cubes, pristine cubes, and Au‐deposited small nanocubes bound by entirely {100} facets are all photocatalytically inactive. X‐ray photoelectron spectra (XPS) showed identical copper peak positions for these Au‐decorated crystals. Remarkably, electron paramagnetic resonance (EPR) measurements indicated a higher production of hydroxyl radicals for the photoirradiated Cu2O rhombic dodecahedra than for the octahedra, but no radicals were produced from photoirradiated Cu2O cubes. The Cu2O {100} face may present a high energy barrier through its large band edge bending and/or electrostatic repulsion, preventing charge carriers from reaching to this surface. The conventional photocatalysis model fails in this case. The facet‐dependent photocatalytic differences should be observable in other semiconductor systems whenever a photoinduced charge‐transfer process occurs across an interface.
Gated Channels and Selectivity Tuning of CO2 over N2 Sorption by Post‐Synthetic Modification of a UiO‐66‐Type Metal–Organic Framework
Authors: Kronast Alexander , Eckstein Sebastian , Altenbuchner Peter T. , Hindelang Konrad , Vagin Sergei I. , Rieger Bernhard 
Published: August 2016

AbstractThe highly porous and stable metal–organic framework (MOF) UiO‐66 was altered using post‐synthetic modifications (PSMs). Prefunctionalization allowed the introduction of carbon double bonds into the framework through a four‐step synthesis from 2‐bromo‐1,4‐benzenedicarboxylic acid; the organic linker 2‐allyl‐1,4‐benzenedicarboxylic acid was obtained. The corresponding functionalized MOF (UiO‐66‐allyl) served as a platform for further PSMs. From UiO‐66‐allyl, epoxy, dibromide, thioether, diamine, and amino alcohol functionalities were synthesized. The abilities of these compounds to adsorb CO2 and N2 were compared, which revealed the structure–selectivity correlations. All synthesized MOFs showed profound thermal stability together with an increased ability for selective CO2 uptake and molecular gate functionalities at low temperatures.
Hydrothermal Synthesis of a rGO Nanosheet Enwrapped NiFe Nanoalloy for Superior Electrocatalytic Oxygen Evolution Reactions
Authors: Geng Jing , Kuai Long , Kan Erjie , Sang Yan , Geng Baoyou 
Published: August 2016

AbstractGraphene‐based hybrid nanostructures possess many advantages in the field of electrochemical energy applications. In this work, a facile and efficient hydrothermal approach has been developed for the preparation of NiFe alloy nanoparticles/rGO hybrid nanostructures, in which the nanoparticles are well combined with rGO nanosheets and the size of the nanoparticles is about 100 nm. Moreover, the electrochemical oxygen evolution reaction (OER) tests confirmed that the obtained NiFe/rGO hybrid nanostructures possess notably higher activity than both the rGO‐free NiFe nanoparticles and pure Ni/rGO hybrids, and the optimal NiFe ratio is 2:1. The OER overpotential at 20 mA cm−1−2 with Ni2Fe/rGO is as low as 0.285 V, which is 96 mV lower than that of pure Ni/rGO hybrids. Meanwhile, the Ni2Fe/rGO catalyst has excellent stability. Therefore, this work contributes a facile and efficient method to prepare a NiFe alloy nanoparticles/rGO hybrid structure for potential applications in the field of electrochemical energy devices, such as electrochemical water splitting cells, rechargeable metal/air batteries, etc.
Nickel‐Promoted Recognition of Long DNA Sites by Designed Peptide Derivatives
Authors: Rodríguez Jéssica , Mosquera Jesús , Vázquez M. Eugenio , Mascareñas José L. 
Published: August 2016

AbstractWe describe the synthesis of designed peptidic modules that self‐assemble in specific DNA sequences of 12 base pairs in the presence of NiII salts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal‐chelating His and bipyridine ligands.
Mechanochemical Strecker Reaction: Access to α‐Aminonitriles and Tetrahydroisoquinolines under Ball‐Milling Conditions
Authors: Hernández José G. , Turberg Mathias , Schiffers Ingo , Bolm Carsten 
Published: August 2016

AbstractA mechanochemical version of the Strecker reaction for the synthesis of α‐aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding α‐aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker‐type multicomponent reaction allowed the one‐pot synthesis of tetrahydroisoquinolines after a subsequent internal N‐alkylation reaction.
Hydrophobicity‐Driven Self‐Assembly of an Eighteen‐Membered Honeycomb Lattice with Almost Classical Spins
Authors: Zhou Guo‐Jun , Richter Johannes , Schnack Jürgen , Zheng Yan‐Zhen 
Published: August 2016

AbstractThe design and synthesis of model compounds that do not exist naturally is one of the important targets in modern coordination chemistry. Herein, an eighteen‐membered honeycomb structure with equal numbers of MnII (s=5/2) and GdIII (s=7/2) metal centers has been prepared, for the first time, by using a hydrophobic force‐directed self‐assembling process. Due to the weakly coupled GdIII pairs, the magnetic properties are mainly determined by eight‐membered chains in the experimentally considered temperature range. These [Mn4Gd4] ”finite‐size“ chains, albeit with large Hilbert space, can be fully resolved by the high‐temperature series expansion and the powerful finite‐temperature Lanczos method, which reveal that the exchange‐couplings between the metal centers are antiferromagnetic and consistent with the magnetization measurement. Interestingly, from the surface‐engineering point of view, the [Mn4Gd4] chains are ”precisely“ assembled into a 2D honeycomb pattern, which is potentially desirable in the design of weakly coupled qubits.
Validation of a Chiral Liquid Chromatographic Method for the Degradation Behavior of Flumequine Enantiomers in Mariculture Pond Water
Authors: Wang Yan‐Fei , Gao Xiao‐Feng , Jin Huo‐Xi , Wang Yang‐Guang , Wu Wei‐Jian , Ouyang Xiao‐Kun 
Published: August 2016

AbstractIn this work, flumequine (FLU) enantiomers were separated using a Chiralpak OD‐H column, with n‐hexane‐ethanol (20:80, v/v) as the mobile phase at a flow rate of 0.6 mL/min. Solid phase extraction (SPE) was used for cleanup and enrichment. The limit of detection, limit of quantitation, linearity, precision, and intra/interday variation of the chiral high‐performance liquid chromatography (HPLC) method were determined. The developed method was then applied to investigate the degradation behavior of FLU enantiomers in mariculture pond water samples. The results showed that the degradation of FLU enantiomers under natural, sterile, or dark conditions was not enantioselective. Chirality 28:649–655, 2016. © 2016 Wiley Periodicals, Inc.
Discovery and Characterization of ACT‐451840: an Antimalarial Drug with a Novel Mechanism of Action
Authors: Boss Christoph , Aissaoui Hamed , Amaral Nathalie , Bauer Aude , Bazire Stephanie , Binkert Christoph , Brun Reto , Bürki Cédric , Ciana Claire‐Lise , Corminboeuf Olivier , Delahaye Stephane , Dollinger Claire , Fischli Christoph , Fischli Walter , Flock Alexandre , Frantz Marie‐Céline , Girault Malory , Grisostomi Corinna , Friedli Astrid , Heidmann Bibia , Hinder Claire , Jacob Gael , Le Bihan Amelie , Malrieu Sophie , Mamzed Saskia , Merot Aurelien , Meyer Solange , Peixoto Sabrina , Petit Nolwenn , Siegrist Romain , Trollux Julien , Weller Thomas , Wittlin Sergio 
Published: August 2016

AbstractMore than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub‐Saharan Africa, Central and South America, and Asia. Resistance to standard therapy, including artemisinin combinations, is increasing. There is an urgent need for novel antimalarials with new mechanisms of action. In a phenotypic screen, we identified a series of phenylalanine‐based compounds that exhibit antimalarial activity via a new and yet unknown mechanism of action. Our optimization efforts culminated in the selection of ACT‐451840 [(S,E)‐N‐(4‐(4‐acetylpiperazin‐1‐yl)benzyl)‐3‐(4‐(tert‐butyl)phenyl)‐N‐(1‐(4‐(4‐cyanobenzyl)piperazin‐1‐yl)‐1‐oxo‐3‐phenylpropan‐2‐yl)acrylamide] for clinical development. Herein we describe our optimization efforts from the screening hit to the potential drug candidate with respect to antiparasitic activity, drug metabolism and pharmacokinetics (DMPK) properties, and in vivo pharmacological efficacy.
Second malignancy risk among pediatric, adolescent, and young adult survivors of fusion‐positive and fusion‐negative sarcomas: Results from the SEER database, 1992 through 2012
Authors: Lupo Philip J. , Brown Austin L. , Hettmer Simone 
Published: August 2016

BACKGROUNDThe current study builds on the hypothesis that cancer‐predisposing germline mutations are less common among patients with fusion‐positive (F+) sarcomas compared to those with fusion‐negative (F‐) sarcomas, resulting in a lower risk of developing second malignant neoplasms (SMNs) in those with F + sarcomas.METHODSStandardized incidence ratios (SIRs) for developing SMNs were evaluated in 4822 survivors of F + and 3963 survivors of F‐ sarcomas that were diagnosed between 1992 and 2012 in pediatric, adolescent, and young adult patients (aged birth‐39 years) and reported in the Surveillance, Epidemiology, and End Results (SEER) database. Cox proportional hazards models (adjusted hazard ratio [aHR]) and competing risk methods (subhazard ratio [sHR]) were used to evaluate SMN risk in those with F‐ versus F + sarcomas while controlling for demographic and clinical variables.RESULTSSMN risk was found to be nearly 2‐fold greater among survivors of F + sarcomas (SIR, 1.86; 95% confidence interval [95% CI], 1.48‐2.30) and nearly 3‐fold greater among survivors of F‐ sarcomas (SIR, 2.89; 95% CI, 2.30‐3.59) compared with the reference population. Although SMN types were noted to be similar between the fusion groups, the rate of any SMN was noted to be greater among survivors of F‐ sarcomas (aHR, 1.38 [95% CI, 1.01‐1.89] and sHR, 1.27 [95% CI, 0.94‐1.73]) when compared with survivors of F + sarcomas. The difference was most notable for solid tumor SMNs after index sarcomas were diagnosed between 2002 and 2012, for which rates of SMN were >2‐fold greater among survivors of F‐ sarcomas (aHR, 2.31 [95% CI, 1.20‐4.48] and sHR, 2.24 [95% CI, 1.13‐4.43]).CONCLUSIONSThe findings of the current study highlight the increased SMN risk experienced by survivors of sarcoma and demonstrate higher SMN rates in survivors of F‐ sarcomas compared to those with a history of F + sarcomas. Cancer 2016;122:3492–3500. © 2016 American Cancer Society