bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Qué hay de nuevo en el tratamiento de la amiloidosis? Parte 3: Polineuropatía amiloidótica familiar
Authors: Bendelman Gisela , Carretero Marcelina , Pérez de Arenaza Diego , Villanueva Eugenia , Brulc Erika B. , Nucifora Elsa M. , Marco María A. , Sáez María S. , Sorroche Patricia , Aguirre María A. , Posadas Martínez María L. 
Published: September 2024

La amiloidosis por depósito de transtiretina es una enfermedad infrecuente y se debe al depósito de fibrillas de dicha proteína en diversos tejidos, aunque la afectación más frecuente es la cardíaca y la neurológica. Puede ser adquirida (antiguamente llamada “amiloidosis senil”) o, menos frecuentemente, hereditaria debido a mutaciones en el gen que codifica para la transtiretina (TTR). Una manifestación habitual de la TTR mutada (de ahora en adelante ATTRv) es la polineuropatía amiloidótica familiar.
En el Hospital Italiano de Buenos Aires, desde el año 2010 existe un grupo transdisciplinario de profesionales nucleados por el interés en optimizar la atención de personas con amiloidosis, formado por profesionales de distintas especialidades y de referencia a nivel nacional, con foco en la asistencia, la docencia y la investigación. En el año 2020, este grupo, denominado Grupo de Estudio de Amiloidosis (GEA), confeccionó guías de práctica clínica para el tratamiento de la polineuuropatía amiloidótica familiar.
Desde entonces se han publicado múltiples ensayos clínicos que aportan contundencia al conocimiento disponible hasta el momento, mientras están en desarrollo nuevas líneas de investigación que robustecen y estimulan el estudio en el área.
En esta revisión se realiza una actualización de las guías existentes en lo que respecta al tratamiento de la polineuropatía amiloidótica familiar por transtiretina y se explora el estado del arte.
En el tratamiento de la polineuropatía amiloidótica familiar es conocido el uso del patisirán (un siRNA o small interfering RNA dirigido a interferir con la síntesis hepatocitaria de transtiretina). Actualmente está aprobado también para pacientes con trasplante hepático previo y progresión sintomática.
Además de este medicamento, hoy se recomienda el vutrisirán, de la misma familia farmacológica pero con una posología de más fácil manejo y un perfil aceptable de efectos adversos.
La edición génica in vivo también está en boga como nueva línea de investigación, siendo parte de múltiples ensayos clínicos actuales en curso.
REASSESSMENT OF THE URANIUM RESOURCE BASE OF PROSPECTIVE AREAS OF THE VITIMSKY URANIUM MINE DISTRICT, TAKEN INTO ACCOUNT OF THE SITUATION LEVEL OF THE PRODUCTIVE AQUIFER AND THE BOTTOM OF PERFORMANCE ROCKS
Authors: Даниленко А.С. , Василевский П.Ю. , Ермакова Д.А. , Дедюлин И.Н. 
Published: September 2024

Статья посвящена оценке прироста ресурсной базы урана Витимского урановорудного района за счет вовлечения в отработку слабообводненных залежей. Авторами проведена работа по созданию базы данных результатов геологоразведочных работ, разработке региональной геофильтрационной модели. В результате моделирования получены карты кровли и уровней продуктивного горизонта. Сопоставление карт позволило оконтурить слабообводненные залежи, оценить их ресурсы и сформировать рекомендации по доизучению гидрогеологических условий.
The article is devoted to assessing the increase in the uranium resource base of the Vitim uranium ore region due to the involvement of low-water deposits in the development. The authors carried out work to create a database of geological exploration results and develop a regional geofiltration model. As a result of modeling, maps of the roof and levels of the productive horizon were obtained. Comparison of maps made it possible to delineate poorly watered deposits, assess their resources and formulate recommendations for additional study of hydrogeological conditions.
Impact of a Clinical Placement on Pre-Professional Health Students Perceived Knowledge, Skills, and Confidence in the Delivery of Behaviour Change and Physical Activity Support
Authors: Lehman Emily , Healy Genevieve N. , Forbes Roma , Laroiya Menakshi , Gomersall Sjaan R. 
Published: September 2024

Background: Clinical placements may provide an appropriate setting for health professional students to learn and apply skills for supporting clients to improve their physical activity. Methods: A mixed methods study was conducted with pre-professional health students completing clinical placement at one of two interprofessional community clinics. Surveys assessed student self-reported perceived skills, knowledge, and confidence for behaviour change and physical activity support pre- and post-placement (unmatched n=40). Interviews were conducted with students (n=18) and clinical educators (n=4). Change in student knowledge, skills, and confidence were assessed using non-parametric tests; qualitative data underwent inductive thematic analysis. Results: Post-placement, unmatched participants perceived knowledge and understanding (p = 0.017), skills (p = 0.001), and confidence (p = 0.004) in behaviour change significantly increased. Perceived confidence in providing physical activity behavior change support for low-risk (p = 0.022) and complex conditions (p = 0.009) significantly improved. Qualitative data emphasised the importance of clinical educators and direct clinical experiences in preparing students for future practice. Conclusion: Student-facilitated interprofessional clinical placements may be important for developing pre-professional knowledge, skills, and confidence in delivering behaviour change and physical activity support. Further exploration of clinical placement opportunities for strengthening pre-professional health students training in physical activity promotion and behaviour change is recommended.
STYLISTIC FEATURES OF THE ICON “ST. NICHOLAS THE WONDERWORKER” FROM THE VILLAGE OF AREFINO, NIZHNY NOVGOROD REGION
Authors: Садова А.С. , Большакова А.В. 
Published: September 2024

На завершающем этапе работы над реставрацией иконы святого Николая Чудотворца был проведен детальный анализ стилистических особенностей памятника. Для этого в рамках дипломного проекта был реализован ряд технико-технологических исследований. Была поставлена проблема принадлежности иконы к определенной школе, для чего был изучен ряд специализированных литературных источников. Продолжена работа по утоньшению потемневшей лаковой пленки на заданном участке.
At the final step of the restoration of the icon of St. Nicholas the Wonderworker, a more detailed stylistic analysis of the features of the monument was conducted. For this purpose, a number of technical and technological analyses were carried out within the framework of the graduation project. The problem of the icon belonging to a certain school is posed, a number of specialized literary sources was studied. The work on thinning the darkened lacquer film on the given area was continued.
PROBLEMS OF DEVELOPING RESTORATION TECHNIQUES FOR CONSERVATION OF PAINTINGS ON THE CENTRAL PART OF THE VAULT OF THE LOWER TEMPLE OF THE HOLY LIFE-GIVING TRINITY CHURCH IN THE VILLAGE OF VOSCHAZHNIKOVO, YAROSLAVL REGION
Authors: Кулишова М.В. , Иванова А.П. , Платова И.А. 
Published: September 2024

Храмовые росписи за время своего бытования сталкиваются с множеством губительных факторов — от переменчивых климатических условий до непредсказуемых исторических событий. Многие проблемы зарождаются еще на этапе создания такой живописи. Все это не только вызывает неизбежные повреждения, но и способствует их значительной неоднородности, несмотря на нахождение росписи в едином интерьерном пространстве. Из‑ за этого различные участки живописной поверхности требуют индивидуального подхода при составлении реставрационной методики и в процессе консервации.
Temple paintings during their existence are associated with many destructive factors – from changeable weather conditions to unpredictable historical events. Many problems arise already at the stage of creating temple paintings. All this not only causes inevitable damage, but also actively contributes to their significant heterogeneity, despite the location of temple paintings in a single interior space. Therefore, different areas of the painting surface require an individual approach when drawing up a restoration methodology and during the conservation process.
THE PROBLEM OF RECONSTRUCTION OF THE ORNAMENTAL COMPOSITION OF BAROQUE PANELS
Authors: Акентьева А.А. , Бахматова А.В. , Еремин Д.А. 
Published: September 2024

Объектами исследования являются филенки барочного иконостаса церкви Живоначальной Троицы села Вощажниково. Основная цель исследования заключается в выполнении реконструкции декоративного убранства для дальнейшей оценки количества реставрационных вмешательств. Особое внимание в работе уделено анализу художественного языка, изучению объекта и поиску авторов. В статье пошагово описываются этапы реконструкции рисунка и приводятся варианты возможного художественного содержания утраченных фрагментов.
The objects of the research are the baroque altar barrier panels at the Church of Life‑ Giving Trinity, Voshazhnikovo village. The main purpose of the research is to carry out the reconstruction of the decoration for the further identification of the restoration interventions. Special attention is given to the analysis of the artistic language, examination of the objects and identification for the authors. The article describes the stages of the ornament reconstruction step by step and provides options for the possible artistic content of the lost fragments.
A study on the sustainability of large sporting events and host cities-the Harbin Asian winter games as an example
Authors: Wu Fengyu , Zheng Guohua 
Published: September 2024

This paper delves into the relationship among major sports events and urban sustainability. The paper takes case study of the Asian winter games in Harbin, China. This paper also explores the effects of support events and presents pragmatic policy options for those countries opting to host significant sporting events. Major sports events have a wider audiences, which offers huge potential for advancing sustainable development in urban societies. The key objectives of the paper is to find out the effects of major sporting events on urban sustainable development using the Asian winter games in Harbin as an example. Important insights explain the important of support events. It aims to enhance the city’s outlook. Moreover, it promote economic progress, and raise the standard of living for its people. This paper highlights the significant opportunity large-scale sports events present for urban sustainable development while underscoring the importance of planning, management, and evaluation. ‘The winter games of Asia presents important lessons for other cities to achieve sustainable development goals better, ensuring the success of hosting major sports events aligns with the city's sustainable development. The results of this paper provide helpful guidance for later similar paper and pragmatic utility.
The science of ladder drills and plyometrics: Enhancing neuromuscular efficiency in athletes
Authors: Ravi Pramod , K Divya 
Published: September 2024

The objectives of this study are to determine whether there is any interaction between agility and athletic performance skills and plyometric training, ladder drill, and agility training; how different these effects are from one another; and how different the effects of low and high agility are from one another. The experimental methodology employed in this work uses a factorial analysis in 2x2. A population of 40 athletes, aged 15 to 17, were selected for the research sample using ordinal pairing. Devices that measure agility using the Illinois Agility Test. The following are the study's findings: The post-test indicates a significant value of p < 0.05, indicating that the plyometric training technique, ladder drill, affects athletic performance skills (p > 0.05). Because the significance value indicates p of 0.006 < 0.05, there is a significant difference between the effects of low and high agility on athletic performance skills (p < 0.05). There is a significant (p > 0.05) interaction between agility (high and low), ladder drill training techniques, and plyometric training methods of athletic performance skills (p < 0.05). The findings indicate that following training, there is a relationship between agility and athletic performance abilities. According to the study, there is a connection between agility (high and low) and athletic performance skills, and agility has a major impact on athletic performance. Training techniques such as plyometric training and ladder drills are also related to agility. Applying the ladder drill and plyometric training techniques affects athletes' performance abilities. It has been demonstrated that doing plyometric and ladder drills may enhance one's athlete's performance ability.
Assessment of the utilization of modern agricultural machinery in rice production and its problems: A case from San Leonardo, Philippines
Authors: S. De Jesus Fhrizz , Mae Ibarra Lyka , Agustin Noel , Anne Murillo Lady , Leyesa Marlon 
Published: September 2024

This study examines the relationship between the utilization of modern agricultural machinery and the business technical aspect of rice production of paddy field farmers in San Leonardo, Nueva Ecija, Philippines. The objective of this study is to assess the effectiveness of modern machinery on the business technical aspect of the farmers and the paddy field owners. The study utilized descriptive analysis to assess the use of modern agricultural machinery in rice production and its problems. The design was quantitative, using percentage, frequencies, and weighted mean. The results revealed that the majority of respondents have been operating for 11 to 20 years, owned 1 hectare of land that cultivate 2 times a year and harvest 86 rice sacks per hectare. Rice cultivation is happened during wet and dry season. To maximizing the land, farmers can try other crops while waiting for the season of rice cultivation. In agricultural mechanization, it concluded that plowing machines helps remove clods from the soil, transplanting rice seedlings and applying chemicals using machine can saves time. Harvester machine is suitable in small and large farmland for harvesting and may help farmers to save time, effort and total cost requirements. Local Government Unit to support through grants and funding the local rice farmers in maximizing utilization of machines that shows positive effect.
The impact of hypoxic training at different altitudes on human physiology, biochemistry, and cytogenetics
Authors: A. Demchenko Georgiy , N. Abdreshov Serik , U. Koibasova Laura , A. Yessenova Makpal , N. Yeshmukhanbet Anar 
Published: September 2024

This study investigated the impact of dosed hypoxic normobaric exercises on the physio-biochemical parameters of blood and lymph circulation, as well as cytogenetic changes in red blood cells (RBC), using a Sprague Dawley Rat Model. Hypoxic training was conducted in an animal hypoxic chamber. The session lasted 34-35 minutes. The O2 content was 20.5% at the beginning of the session; then, it dropped to 14.8% within 4-5 minutes, corresponding to a rise to an altitude of 2,900-3,000 m, and was maintained at that level until the end of the session. The hypoxic training cycle increased the RBC count by 4.1%, the hemoglobin count by 4.2%, the blood oxygen capacity by 8.3%, the circulating blood volume by 16.7%, and interstitial metabolism and lymph circulation by 30.6%. A cytogenetic study revealed an increase in erythropoiesis-reticulocyte count by 40.3% and a slightly higher frequency of micronucleated erythrocytes. We observed economization of the heart, respiration, activation of glucose transport by 33.5%, increased lipid utilization, and increased antioxidant protection. These parameters especially changed when hypoxic training was combined with physical activity. Hypoxic training with physical activity expands the body’s compensatory and adaptive capabilities by increasing the reserves of the respiratory, cardiovascular, and lymphatic systems.
Case law of the European court of human rights on compensation for non-pecuniary damage: Certain issues
Authors: Vitalii Makhinchuk , Volodymyr Bobryk , Denys Pozov , Oleksandra Karmaza , Sergii Koroied 
Published: September 2024

Compensation is considered a means of restoring the violated rights. Ukrainian legislation directly provides for the possibility of compensation for non-pecuniary damage, however, a number of problems arise when considering cases on this issue in national courts. Firstly, there is no legally enshrined definition of this concept in Ukraine. Secondly, there is no single methodology or model for assessing moral damage, no formula for calculation is established at the legislative level, due to which judges assign different amounts of compensation for harm caused under the same or similar circumstances. Besides, there are no clear criteria for determining the amount of damage caused, which makes it almost impossible to unambiguously calculate, for example, the extent of the mental pain or the infringement on dignity and honor in property equivalent, that is, it is in fact a conditional compensation. Reference to the case law of the ECHR on this matter may contribute to solving these problems, because its decisions are referred to by national courts. The ECHR has not developed a universal formula for calculating the amount of non-pecuniary damage, but there are certain criteria for its assessment: the nature of the offense and violated right; payments accrued based on the results of consideration of previous cases; victim’s personality; the respondent State; collective statements or mass offenses; other circumstances of the case.
Implementing Blended Learning within the TPMK Framework to Enhance Mathematics Teachers' Competence
Authors: Winarso Widodo , Udin Tamsik 
Published: September 2024

The post Covid-19 pandemic opens opportunities for teachers to conduct innovative studis in the context of mathematics education. The blended learning model has become the primary choice implemented by teachers during mathematics learning activities in schools. However, discourse related to this matter is still limited. This research investigates the impact of implementing the blended learning model on the Technological Pedagogical and Mathematics Knowledge (TPMK) of mathematics teachers in Madrasah Aliyah (MA) in Indonesia. post-Covid-19 pandemic. The research focuses on aspects of blended learning implementation, the level of TPMK of teachers, and the extent of its impact on the professional development of mathematics teachers. The research method used is correlational design, with data collection conducted through questionnaires given to MA teachers. The results show that implementing blended learning has a significant positive impact on improving the TPMK of mathematics teachers. Research recommendations include expanding training programs for teachers in technology integration, improving digital infrastructure in madrasas, providing incentives for learning innovations, and enhancing cooperation among madrasas. The implications of this research are crucial in providing significant contributions to the development of mathematics education in the madrasah environment. This research can be a foundation for developing more effective educational strategies and policies, particularly in facing and adapting to post-pandemic learning changes.
Surgery do save life in cervical spinal injury: 5 years study of a tertiary care in East Java, Indonesia
Authors: Pratamanugroho Ilham , Agung Irianto Komang , Widhiyanto Lukas , Lestari Pudji 
Published: September 2024

Cervical spine has the most movement in spine therefore it has high risk of injury which may involve vertebrae, soft tissue and spinal cord. Trauma to cervical has highest risk of neurologic deficits due to spinal cord injury (SCI) causing high number of morbidity and mortality. Retrospective study was conducted with descriptive-analytic design by total sampling of cervical spinal injury patients in Dr. Soetomo General Academic Hospital from January 2018 to June 2023. Patient demographic and survival analysis of patients was described using Kaplan-Meier chart and logistic regression test to find factors contributing to patients’ survival. Gender, age, mechanism of injury, surgical approach, duration, intra-operative bleeding, lesion level, time to surgery, and initial blood laboratory had no significant impact while neurological status and operative treatment have significant survival probability. Patients with American Spinal Injury Association Impairment Scale (AIS) A score have lower survival rate which associated with respiratory muscle weakness, cardiovascular and autonomic nervous system dysfunction. Any unstable cervical fracture is advised for surgery while decompression surgery is recommended for improving outcome and ease of rehabilitation. Clinical implication of this study recommends surgery for cervical spinal injury with 5.6 times more chance of survival than non-operative patients. Initial AIS neurological status and surgery performed contributes to survival. Level of cervical lesion, age, gender, mechanism of injury, surgical approach, duration, blood laboratory tests do not have a significant impact on survival while fastest time admission to surgery does not reflect higher chance of survival probability.
Protective effect of long-chain polyunsaturated fatty acids on hepatorenal syndrome in rats
Authors: Duailibe João Bruno Beretta , Viau Cassiana Macagnan , Saffi Jenifer , Fernandes Sabrina Alves , Porawski Marilene 
Published: September 2024

BACKGROUND
Hepatorenal syndrome (HRS) is the most prevalent form of acute kidney injury in cirrhotic patients. It is characterized by reduced renal blood flow and represents the most severe complication in cirrhotic patients with advanced disease. Previous research has indicated that antioxidants can delay the onset of a hyperdynamic circulatory state in cirrhosis and improve renal function in HRS patients. Regular omega-3 supplementation has significantly reduced the risk of liver disease. This supplementation could represent an additional therapy for individuals with HRS.
AIM
To evaluated the antioxidant effect of omega-3 polyunsaturated fatty acid supplementation on the kidneys of cirrhotic rats.
METHODS
Secondary biliary cirrhosis was induced in rats by biliary duct ligation (BDL) for 28 d. We used 24 male Wistar rats divided into the following groups: I (control); II (treated with omega-3, 1 g/kg of body weight); III (BDL treated with omega-3, 1 g/kg of body weight); and IV (BDL without treatment). The animals were killed by overdose of anesthetic; the kidneys were dissected, removed, frozen in liquid nitrogen, and stored in a freezer at -80℃ for later analysis. We evaluated oxidative stress, nitric oxide (NO) metabolites, DNA damage by the comet assay, cell viability test, and apoptosis in the kidneys. Data were analyzed by one-way analysis of variance, and means were compared using the Tukey test, with P ≤ 0.05.
RESULTS
Omega-3 significantly decreased the production of reactive oxygen species (P < 0.001) and lipoperoxidation in the kidneys of cirrhotic rats treated with omega-3 (P < 0.001). The activity of the antioxidant enzymes superoxide dismutase and catalase increased in the BDL+omega-3 group compared to the BDL group (P < 0.01). NO production, DNA damage, and caspase-9 cleavage decreased significantly in the omega-3-treated BDL group. There was an increase in mitochondrial electrochemical potential (P < 0.001) in BDL treated with omega-3 compared to BDL. No changes in the cell survival index in HRS with omega-3 compared to the control group (P > 0.05) were observed.
CONCLUSION
The study demonstrates that omega-3 can protect cellular integrity and function by increasing antioxidant enzymes, inhibiting the formation of free radicals, and reducing apoptosis.