bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Pro‐BNP biomarker in heart failure patients and its relationship with complete blood count parameters: A case–control study
Authors: Torfi Ekhlas , Bahreiny Seyed S. , Saki Najmaldin , Khademi Reyhane , Sarbazjoda Ehsan , Nezhad Inas A. , Aghaei Mojtaba 
Published: September 2024

AbstractBackground and aimsHeart failure (HF) is a growing global health concern. N‐terminal prohormone of brain natriuretic peptide (NT‐pro‐BNP) is an established biomarker for ventricular dysfunction in heart failure (HF). This case–control study examined the relationship between brain natriuretic peptide (Pro‐BNP) levels and complete blood count (CBC) parameters in HF patients and healthy controls, exploring the utility of CBC as a supplementary diagnostic tool for HF.MethodsThe study included 89 participants, divided into 42 HF patients with diagnosed HF (patient group) and 47 healthy individuals (control group). Pro‐BNP levels were measured alongside a comprehensive CBC panel, including parameters such as white blood cell count, hemoglobin levels, and platelet count. Demographic, clinical characteristics, and CBC parameters were compared between the two groups, with statistical analyses performed to identify any significant associations.ResultsThe analysis demonstrated that HF patients had significantly higher Pro‐BNP levels than the control subjects, indicating a strong association between Pro‐BNP levels and HF (1052.65 [196.56] vs. 2500.34 [1105.90], p < 0.001). Moreover, significant differences in CBC parameters, such as platelet count: 246.96 (82.72) versus 206.45 (57.20), p = 0.009; mean corpuscular volume (MCV): 83.74 (5.86) versus 87.12 (4.60), p < 0.00; and red cell distribution width: 13.47 (1.29) versus 14.28 (1.35), p < 0.001) were observed, with the patient group showing altered levels indicative of cardiac stress and inflammation. Correlation analysis further established the relationship between Pro‐BNP levels and CBC parameters, with notable correlations observed with MCV (0.250, p < 0.020) and mean corpuscular hemoglobin levels (0.246, p < 0.045). These findings suggest a complex interplay between Pro‐BNP levels and CBC parameters, underscoring the potential of CBC parameters as auxiliary diagnostic markers in HF.ConclusionPro‐BNP exhibits clinical relevance in diagnosing cardiovascular dysfunction, with elevated levels and distinct hematological profiles in HF patients. Pro‐BNP's diagnostic and predictive capabilities for hematocrit and platelet count support its use in risk assessment and treatment decisions for HF.
Response surface optimization of heat transfer in magnetic nanofluid flow within a permeable square enclosure: Corrugated wall and Joule heating effects
Authors: Umavathi Jawali C. , Sheremet Mikhail A. , Subray Ananth 
Published: September 2024

AbstractThis paper presents a comprehensive numerical computation of the natural convection of magnetized permeable nanoliquids contained within a composite wavy cabinet. The domain of interest includes two parts. One portion is filled with a nanofluid fluid saturated with a porous matrix, whereas the other region is filled solely with the nanofluid. The finite element approach is utilized to solve the coupled highly nonlinear partial differential equations numerically. A selected set of graphical results illustrating the effects of frequency, amplitude, Rayleigh number, Hartmann number, Darcy number, and different porous materials on the streamlines and isotherms are presented. The variations in these parameters enable us to examine the impact on Nusselt number, flow patterns, and thermal performance. The addition of a response surface technique based on sensitivity analysis is a major innovation in this study, and the findings reveal intricate interactions between magnetohydrodynamics (MHDs), Joule heating, and porous medium effects, providing valuable insights into optimizing thermal management and energy efficiency in advanced MHD systems.
Nomogram to predict methotrexate treatment success in ectopic pregnancy
Authors: Zeevi Gil , Bercovich Or , Haring Yael , Nahum Shir , Romano Asaf , Houri Ohad , Yeoshoua Effi , Eitan Ram , Peled Yoav , Krissi Haim 
Published: September 2024

AbstractObjectiveTo evaluate clinical factors prior to methotrexate (MTX) treatment for tubal ectopic pregnancy and to apply the data to a prediction model for treatment success.MethodsA retrospective cohort study was conducted during 2014–2022. Of the 808 patients with a tubal ectopic pregnancy, 372 with a β‐hCG level less than 5000 IU/L were treated with a single dose of MTX and were included in this study. Pretreatment factors, including patient characteristics, initial β‐hCG level, and sonographic parameters, were compared between those who achieved complete resolution and those who needed additional MTX or surgical intervention. A logistic regression model and multivariable analysis were used to predict success. A graphic nomogram was generated to represent the model.ResultsComplete resolution of the ectopic pregnancy was achieved in 290 (77.9%) patients after a single dose of MTX. A second dose or surgical intervention was required for 82 (22.0%): 49 (13.2%) received a second dose of MTX and 33 (8.9%) underwent laparoscopic salpingectomy. In the MTX Success group compared to the MTX Failure group, the median β‐hCG levels were lower (746 vs 1347 IU/L, P < 0.001) and the presence of a yolk sac and a fetal pole were less frequent. The predictive model, based on significant variables, includes initial β‐hCG concentration and the visibility of a yolk sac or fetal pole. Analysis with cross‐validation techniques revealed that the model was both accurate and discriminative.ConclusionA predictive nomogram was developed to predict the success of single‐dose MTX treatment for tubal ectopic pregnancy.
Severe neutropenia caused by palliative radiation therapy in a case of metastatic hormone‐sensitive prostate cancer
Authors: Maesaka Fumisato , Tomioka Atsushi , Matsushita Chie , Horikawa Noriko , Fujimoto Kiyohide 
Published: September 2024

IntroductionRadiotherapy for widespread bone metastasis results in severe hematological toxicity.Case presentationA 71‐year‐old male was diagnosed with metastatic hormone‐sensitive prostate cancer (cT4N1M1b) and treated with apalutamide and degarelix. Concurrently, palliative radiation therapy was sequentially initiated for the 1st, 5th, and 10th thoracic vertebrae and right femur. On day 35 after treatment, severe neutropenia necessitated treatment interruption and required 23 days for neutrophil recovery with a granulocyte colony‐stimulating factor agent.ConclusionOwing to the severe hematologic toxicity caused by extensive radiation therapy for multiple bone lesions, treatment prioritization by lesion and avoiding irradiation of the red bone marrow is essential.
Theoretical study on the luminescent and reaction mechanism of dansyl‐based fluorescence probe for detecting hydrogen sulfide
Authors: Li Huixue , Wang Yvhua , Pan Sujuan , Wang Changqing , Liu Yanzhi , Yuan Kun , Lv Lingling , Li Zhifeng 
Published: September 2024

AbstractThe photophysical and photochemical properties of the sulfonyl azide‐based fluorescent probe DNS–Az and its reduction product DNS by hydrogen sulfide (H2S) have been investigated theoretically. The calculated results indicated the first excited states of DNS–Az was dark state (oscillator strength less than 0.03) and DNS was bright state (oscillator strength more than 0.1), which determined the predicted radiative rate kr of DNS–Az was much smaller than that of DNS, meanwhile, due to more larger reorganization energy of DNS–Az, its predicted internal conversion rate kic was four times larger than that of DNS; moreover, owing to the effect of heavy atom from sulfur atom in DNS–Az, its predicted intersystem crossing rate kisc was seven times larger than that of DNS, thus the calculated fluorescence quantum yield of DNS–Az was only 2.16% and that of DNS was more than 77.2%, the above factors is the basis for DNS–Az molecule to function as a fluorescent probe. Regarding both DNS‐Az and DNS molecules, their maximum Huang‐Rhys factors, which are less than unity, signify the reliability of 0–0 transitions between their S0 and S1 electronic states. In addition, for DNS, our simulated emission peak of the 0–0 transition is 515 nm, a value that exhibits enhanced accuracy and coherence when compared to the experimental datum of 528 nm. The reaction mechanism of DNS‐Az generating DNS by H2S has been investigated too, according to the potential energy profile, we found that the fluorescent probe firstly protonated, then this organic ion broke down into DNS with the aid of a proton.
The neuropsychology of early childhood and infancy
Authors: Megari Kalliopi , Miliadi Vasiliki 
Published: September 2024

AbstractObjectivesPiaget's theory emphasizes the biological structures children utilize to make sense of their environment and based on those experiences become able to adapt. Many factors can intervene in the gradual and complex process of development, causing an array of issues both acute and chronic.MethodSeveral studies have found that disability in the early months is a strong predictor of cognitive impairment in preschool. The presence of early functional anomalies may represent developmental delay and/or neurodevelopmental disorders.ResultsUnderstanding the risk factors and detecting such signs early on is important to prevent or minimize later cognitive, behavioral, and psychosocial problems. The study aims to emphasize how critical the early years are to a child's future cognitive, physical, emotional, and social development as well as their overall well‐being.DiscussionIn addition, the fact that crucial developmental stages can be hampered or obstructed by a variety of factors is highlighted.
Synthesis, Fluorescence Properties, Molecular Docking Studies, and Analysis of the Crystalline Structure of the Novel 5‐Imino‐7‐Aryl‐5H‐Thiazolo[3.2‐a]Pyrimidine‐6‐Carbonitrile and Its Derivatives
Authors: Touati Yousseuf , Benabdallah Mohammed , Merabat Ihcen , Sejas Julio A. , Hassaine Ridha , Djafri Ahmed , Bouchama Abdelghani , Chouaih Abdelkader , Vázquez‐Tato M. P. , Choukchou‐Braham Noureddine 
Published: September 2024

ABSTRACTThis study describes a simple, inexpensive, and effective method for the synthesis of new 5‐imino‐7‐aryle‐5H‐thiazolo[3,2‐a]pyrimidine‐3‐carbonitrile derivatives 4a‐e using a green procedure that does not require the use of heat or a base, creating a strategy that meets both economic and environmental demands. Various synthesized products were characterized via diverse techniques such as 1H‐NMR, infrared (FT‐IR), Mass spectroscopy (MS), and single crystal X‐ray diffraction. Using a fluorescence spectrometer, the 5‐imino‐7‐phenyle‐5H‐thiazolo[3.2‐a]pyrimidine‐3‐carbonitrile 4a has been tested as a potent fluorescent agent in mixture of DMSO/Water at 10−4 M in one hand, and on the other hand the results of our fluorescence evaluation studies with metal ions (Pb(II), Ba(II), Cd(II), Ni(II), Mn(II), Hg(II), Zn(II), Fe(II), Co(II), Cu(II), La(II), Cr(III), and Fe(III)) have shown that this compound exhibits a turn‐on and turn‐off of the fluorescence to 4a compound with these metals, what forms poor to good interaction by these ions. This result represents the emergence of a new potential ligand for the two heavy cations Cd(II) and Pb(II), which are toxic and polluting, and whose detection is currently of high interest. As well, In the molecular docking evaluation study, it was determined that the 4e molecule has an exceptional ability to inhibit the binding energy of the tubulin protein by −9.13 kcal/mmol, compared to other compounds. The results demonstrate the possibilities for a novel oral medication application.
Synthesis and Anticancer Evaluation of Tryptanthrin‐1,2,3‐Triazole Hybrids
Authors: Meenakshy C. B. , Sruthi Sudheendran Leena , Jayasree E. G. , Sandhya Karakkadparambil Sankaran , Deepthi Ani 
Published: September 2024

ABSTRACTSynthesis of 18 tryptanthrin‐triazole hybrid molecules by employing Cu(I)‐catalyzed azide‐alkyne [3 + 2] cycloaddition (CuAAC) between tryptanthrin oxime O‐propargyl ether and aromatic azides is described here. The exclusive formation of E‐triazoles was confirmed by theoretical studies using the M06‐2x/6–311++G(d,p) level. From the synthesized triazoles, four of them have been selected and were subjected to in vitro anticancer activity studies against selected cell lines. Furthermore, in silico studies have been conducted for the most active compound, 5h, and it suggested that various noncovalent interactions and one conventional hydrogen bond enhance the stability of the complex (binding affinity = −11.29 kcal/mol). ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) studies also prove the increased biological potency of 5h.
An Expedited Qualitative Profiling of Free Amino Acids in Plant Tissues Using Liquid Chromatography‐Mass Spectrometry (LC–MS) in Conjunction With MS‐DIAL
Authors: Kaachra Anish , Tamang Anish , Hallan Vipin 
Published: September 2024

ABSTRACTThe estimation of relative levels of amino acids is crucial for understanding various biological processes in plants, including photosynthesis, stress tolerance, and the uptake and translocation of nutrients. A wide range of liquid chromatography (LC; HPLC/UHPLC)‐based methods is available for measuring the quantity of amino acids in plants. Additionally, the coupling of LC with mass spectrometry (MS) significantly enhanced the robustness of existing chromatographic methods used for amino acid quantification. However, accurate annotation and integration of mass peaks can be challenging for plant biologists with limited experience in analyzing MS data, especially in studies involving large datasets with multiple treatments and/or replicates. Further, there are instances when the experiment demands an overall view of the amino acids profile rather than focusing on absolute quantification. The present protocol provides a detailed LC–MS method for obtaining a qualitative amino acids profile using MS‐DIAL, a versatile and user‐friendly program for processing MS data. Free amino acids were extracted from the leaves of control and Tomato leaf curl Palampur virus (ToLCPalV)‐infected Nicotiana benthamiana plants. Extracted amino acids were derivatized and separated using UHPLC‐QTOF, with each amino acid subsequently identified by aligning mass data with a custom text library created in MS‐DIAL. Further, MS‐DIAL was employed for internal standard‐based normalization to obtain a qualitative profile of 15 amino acids in control and virus‐infected plants. The outlined method aims to simplify the processing of MS data to quickly assess any modulation in amino acid levels in plants with a higher degree of confidence.
Unraveling Stacking Transitions in Twisted Bilayer Graphene: Insights From Intralayer and Interlayer Processes
Authors: Souibgui M. 
Published: September 2024

ABSTRACTIn this paper, we investigate a twisted bilayer graphene on an h‐BN substrate. The graphene is grown using high‐quality chemical vapor deposition (CVD) and subsequently transferred onto the h‐BN substrate. Our focus is on the stacking transition within the bilayer system, based on fluctuations in both intralayer and interlayer processes. Our findings reveal that post‐annealing induces alterations in the electron–phonon interaction, corresponding to the spatially dependent stacking changes in the bilayer structure. This makes it possible to modify the electronic band structure of graphene and subsequently all its optoelectronic properties.
Effect of chitosan on thermal gelling properties of pork myofibrillar protein and its mechanism
Authors: Zhang Huiyun , Li Xinling , Zhang Ziye , Jiang An , Bai QiaoQiao 
Published: September 2024

AbstractBACKGROUNDPrevious studies have demonstrated that the addition of chitosan can improve the quality and functional properties of meat products. However, the underlying mechanism remains unclear. In this study, the effect and mechanism of the addition of chitosan on the gel properties of myofibrillar protein (MP) were investigated.RESULTSThe results indicated that the gel strength and the water‐holding capacity of MP‐chitosan gel increased significantly when chitosan was added at 2.5–10 mg mL−1. Myofibrillar protein samples with 10 mg mL−1 added chitosan exhibited the highest elasticity and viscosity during gel formation and strengthening. The addition of chitosan also caused a modification in both the secondary and tertiary structure of MP, resulting in an enhanced exposure of hydrophobic and sulfhydryl groups in comparison with the control. Chitosan inhibited the conversion of immobilized water into free water and the formation of water channels during the thermal gelation process of MP. The denaturation enthalpy (ΔH) of myosin decreased as the concentration of chitosan exceeded 5 mg mL−1. The microstructure showed that the incorporation of chitosan (5–10 mg mL−1) facilitated the formation of compact and well organized MP gel networks.CONCLUSIONThe addition of chitosan can enhance the functional properties of meat protein and facilitate heat‐induced gelation, making it a promising ingredient for improving the quality of processed meat products. © 2024 Society of Chemical Industry.
Late (≥60 years old) and middle adulthood (40–59 years old) patients achieve similar improvement in patient‐reported outcomes following ACL reconstruction
Authors: Pohl Nicholas B. , Fitzgerald Patrick , Brush Parker L. , Fletcher Daniel J. , Hornstein Joshua 
Published: September 2024

AbstractPurposeThis study aimed to compare the range of motion (ROM), surgical outcomes, and patient‐reported outcome measures (PROMs) following anterior cruciate ligament (ACL) reconstruction outcomes in patients 60 years or older at the time of surgery to 40‐ to 59‐year‐old patients.MethodsIn this retrospective cohort study from 2015 to 2022, a 3:1 propensity match was performed to match late adulthood patients (≥60 years old) undergoing ACL reconstruction with middle adulthood (40–59 years old) ACL reconstruction patients. Patients were matched based on sex, ACL graft utilized and concomitant procedures performed during ACL reconstruction. Statistical analysis compared demographics, preoperative injury management, surgical outcomes, PROMs, and minimal clinical important difference (MCID) and substantial clinical benefit (SCB) achievement rates for all ACL reconstruction patients included.ResultsTwenty late adulthood and 60 middle adulthood patients who underwent ACL reconstruction were included in the final cohort. Patients who were 60 years or older experienced no difference in reoperation rate (n.s.), incidence of retears (n.s.) or ROM (n.s.) at 1 year post‐operatively. There were also no differences in International Knee Documentation Committee (ΔIKDC) (31.3 ± 19.1 vs. 34.2 ± 18.2, n.s.) or ΔPCS‐12 (12.4 ± 9.8 vs. 12.9 ± 10.8, n.s.) scores at 1 year post‐operatively. Furthermore, the younger and older patient cohorts demonstrated similar rates of achieving the MCID (80.0% vs. 83.3%, n.s.) and SCB (50.0% vs. 61.7%, n.s.) scores for IKDC.ConclusionPatients 60 years or older and 40‐ to 59‐year‐old patients demonstrated similar outcomes after undergoing ACL reconstruction with allograft. This study concludes that ACL reconstruction in late adulthood can still be a successful treatment option and should allow surgeons to feel more comfortable when performing indicated surgical intervention for older patients who experience an ACL tear.Level of EvidenceLevel III, Therapeutic III, retrospective cohort study.
Outcomes of heliox use in children with respiratory compromise: A 10‐year single institution experience
Authors: Young Ashley , Stein Eli , Rowland Matthew , Valika Taher , Ghadersohi Saied , Hazkani Inbal 
Published: September 2024

AbstractObjectiveHeliox, a mixture of helium and oxygen, has been shown to improve laminar airflow and decrease airway resistance in children. This study aims to describe the outcomes of heliox use in children with respiratory compromise and to identify variables associated with a need for airway surgical intervention.MethodsA retrospective cohort study of patients who received heliox between 2012 and 2022 at a tertiary care children's hospital.ResultsA hundred and thirty‐eight heliox treatments were recorded in 119 children. Twelve patients were excluded. Most (n = 100, 84%) patients had significant comorbidities. On average, patients spent a cumulative mean of 94 ± 187 h on heliox therapy per hospital admission. Patients with croup or asthma without known airway pathology presented at an older age than patients with other indications for heliox therapy (4.0 ± 4.7 vs. 2.2 ± 3.6 years, p = 0.04) and were significantly less likely to have background diseases (n = 14, 52% vs. n = 74, 93%, p < 0.0001). Overall, 51 (47.7%) patients were recommended tracheostomy placement, airway reconstruction, or palliative care. Cumulative use of heliox for more than 47 h was associated with an increased risk of needing tracheostomy or airway reconstruction (odds ratio 6.2, 95% confidence intervals 2.56–14.13, p < 0.0001). In multivariable regression analysis, neuromuscular disease, intracranial neuropathology, and cumulative time of heliox were associated with a need for definitive airway intervention.ConclusionsHeliox may be used as a temporizing agent in children with upper airway obstruction. The effectiveness of heliox use for more than 47 h in children, especially in the presence of neuromuscular disease and intracranial neuropathology should be reconsidered.Level of evidence: 4.
A 225–300 GHz broadband frequency tripler using accurate series resistance model
Authors: Wei Haomiao , Zhang Yong , Cha Xingzeng , Zhu Huali , Chen Yang 
Published: September 2024

AbstractThis paper proposed an accurate series resistance model tailored for Schottky diode‐based terahertz multipliers. Compared to the conventional electrothermal model (E‐T model) only considering thermal effects, this model comprehensively accounts for both thermal and frequency effects of the series resistor components, including the temperature‐dependent epilayer resistance (Repi) and the temperature‐frequency‐dependent spreading resistance (Rspreading). The evaluation of thermal effects relies on steady‐state thermal simulation and the corresponding electrothermal model. Notably, the frequency‐dependent spreading resistance part is derived from the fitting conductivity of doped buffer layers and extracted by auxiliary three‐dimensional electromagnetic simulations. Based on this model, a balanced 225–300 GHz frequency tripler with AlN substrate has been designed and manufactured. By introducing this model, a significant improvement in the consistency between simulated and measured results has been achieved compared to the single E‐T model, regardless of whether the input power is low (80 mW) or high (160 mW).