bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiosynthesis and in vivo Evaluation of Carbon‐11 (2S)‐3‐(1H‐Indol‐3‐yl)‐2‐{[(4‐methoxyphenyl)carbamoyl]amino}‐N‐{[1‐(5‐methoxypyridin‐2‐yl)cyclohexyl]methyl}propanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation
Authors: Lacivita Enza , Stama Madia Letizia , Maeda Jun , Fujinaga Masayuki , Hatori Akiko , Zhang Ming‐Rong , Colabufo Nicola A. , Perrone Roberto , Higuchi Makoto , Suhara Tetsuya , Leopoldo Marcello 
Published: June 2016

Here, we describe the very first attempt to visualize in vivo formyl peptide receptors (FPRs) in mouse brain by positron emission tomography (PET). FPRs are expressed in microglial cells where they mediate chemotactic activity of β‐amyloid peptide in Alzheimer disease and, thus, are involved in neuroinflammatory processes. To this purpose, we have selected (2S)‐3‐(1H‐Indol‐3‐yl)‐2‐{[(4‐methoxyphenyl)carbamoyl]amino}‐N‐{[1‐(5‐methoxypyridin‐2‐yl)cyclohexyl]methyl}propanamide ((S)‐1), that we have previously identified as a potent non‐peptidic FPR agonist. (S)‐[11C]‐1 has been prepared in high radiochemical yield. (S)‐[11C]‐1 showed very low penetration of blood–brain barrier and, thus, was unable to accumulate into the brain. In addition, (S)‐[11C]‐1 was not able to label FPRs receptors in brain slices of PS19 and APP23 mice, two animal models of Alzheimer disease. Although (S)‐[11C]‐1 was not suitable to visualize FPRs in the brain, this study provides useful information for the design and characterization of future potential PET radioligands for visualization of brain FPRs by PET.
Prenatal diagnosis of the rare association of common arterial trunk and double aortic arch
Authors: Rock Andrea , Eltayeb Osama , Camarda Joseph , Gotteiner Nina 
Published: June 2016

Key Clinical MessageCommon arterial trunk with associated double aortic arch is a very rare constellation of congenital heart disease. Prenatal diagnosis allows for surgical repair prior to development of respiratory morbidity, which is otherwise described in all cases with this association.
Kussmaul's sign and rapid X‐Y descents in constrictive pericarditis
Authors: Pussadhamma Burabha , Wongvipaporn Chaiyasith 
Published: June 2016

Key Clinical MessageRight‐sided heart failure is not uncommon. A careful jugular venous examination looking for the distinct Kussmaul's sign and rapid X‐Y descents, which are highly indicative of constrictive pericarditis, is markedly helpful in guiding the correct diagnosis and proper management.
Coupling of a Liquid Organic Hydrogen Carrier System with Industrial Heat
Authors: Krieger Christoph , Müller Karsten , Arlt Wolfgang 
Published: June 2016

AbstractEnergy storage is needed for adjusting fluctuating renewable energies to the actual energy demand. A liquid organic hydrogen carrier (LOHC) system is examined for its suitability as a storage system for industrial applications. Integration of the LOHC system, e.g., into a cement plant allows for optimized utilization of waste heat. The exhaust heat from the cement plant can increase the efficiency of the storage system. The effectiveness of the LOHC system can be elevated by twelve percentage points. The working electricity costs of the cement plant can be significantly reduced by adding a LOHC storage system.
Effect of the Synthesis Route and Fe Presence on the Redox Activity of Ni in Layered Double Hydroxides
Authors: Scavetta Erika , Vlamidis Ylea , Posati Tamara , Nocchetti Morena , Tonelli Domenica 
Published: June 2016

AbstractPt electrodes coated with a Ni/Al or Ni/Fe layered double hydroxide (LDH) were studied to investigate whether the presence of Fe and the extent of crystallinity affect the performance of the Ni centers as redox mediators for oxidizable compounds. The LDHs were synthesized by both a chemical and an electrochemical method, which allowed the obtainment of thin and well‐adherent LDH films having similar morphology but a different crystallinity degree. Fe centers were not electroactive but they influenced the electroactivity of Ni, shifting the redox potential to less anodic values and increasing the percentage of the electroactive Ni sites. The LDHs prepared by electrodeposition were more conductive than the chemically synthesized LDHs, and, when Fe was the trivalent metal, the electronic conductivity was further increased. The highest electrocatalytic efficiency, evaluated taking glucose as model compound, was obtained for the electrodes coated with the electrochemically synthesized LDHs.
1D Alignment of PEDOT in a Buckypaper for High‐Performance Solid Supercapacitors
Authors: Soni Roby , Anothumakkool Bihag , Kurungot Sreekumar 
Published: June 2016

AbstractA flexible solid‐state supercapacitor is prepared from carbon nanotube (CNT)‐based buckypaper after forming a thin layer of polyethylenedioxythiophene (PEDOT) on the surface of the CNTs in the paper. A highly conducting PEDOT phase is obtained by interfacial polymerization, in which polymerization is confined at the interface of two immiscible liquids. The hydrophilic interaction between the functionalized CNTs and the oxidizing agent (iron perchlorate, Fe(ClO4)3), which is located in the aqueous phase, and the restricted interaction of the oxidizing agent with the EDOT monomer in the organic layer at the immiscible interface play a vital role in establishing a uniform and aggregate‐free growth pattern of PEDOT on CNT. By carefully optimizing the amount of polymer in the paper, an electrode with a sheet resistance of 3.4 Ω □−1 and equivalent series resistance of 0.95 Ω can be prepared. A thin and flexible solid‐state supercapacitor device with an overall thickness of 210 μm is made by using this paper as the electrodes and poly(vinyl alcohol)/lithium chloride as the gel electrolyte. The power density and energy density of the electrode are 9.94 W cm−3 and 8.85 mWh cm−3, respectively. The device also delivers a high volumetric capacitance of 18 F cm−3 and areal capacitance of 354 mF cm−2. The demonstrated strategy is scalable and hence the process can be conveniently applied to prepare large‐area PEDOT‐modified buckypapers in a short time.
ChemInform Abstract: Interplay of Orbital and Relativistic Effects in Bismuth Oxyhalides: BiOF, BiOCl, BiOBr, and BiOI.
Authors: Ganose Alex M. , Cuff Madeleine , Butler Keith T. , Walsh Aron , Scanlon David O. 
Published: June 2016

AbstractStudy by using hybrid DFT with explicit treatment of spin—orbit coupling effects and dispersion interactions.
ChemInform Abstract: New Insights into the Application of the Valence Rules in Zintl Phases — Crystal and Electronic Structures of Ba7Ga4P9, Ba7Ga4As9, Ba7Al4Sb9, Ba6CaAl4Sb9, and Ba6CaGa4Sb9.
Authors: He Hua , Stoyko Stanislav , Bobev Svilen 
Published: June 2016

AbstractCrystals of Ba7Al4Sb9 (I), Ba7Ga4P9 (II), and Ba7Ga4As9 (III) are prepared by melting the respective elements in molten Al or Pb fluxes (evacuated silica tubes, 960 °C, 20 h (Al flux) or 40 h (Pb flux)).
ChemInform Abstract: Thermal Properties and Phase Transition in the Fluoride, (NH4)3SnF7.
Authors: Kartashev A. V. , Gorev M. V. , Bogdanov E. V. , Flerov I. N. , Laptash N. M. 
Published: June 2016

Abstract(NH4)3SnF7 is prepared by dissolution of Te in excess HF to which HNO3 is carefully given and followed by pH adjustment to 4—5 via NH3 addition.
ChemInform Abstract: Hf3Fe4Sn4 and Hf9Fe4‐xSn10+x: Two Stannide Intermetallics with Low‐Dimensional Iron Sublattices.
Authors: Calta Nicholas P. , Kanatzidis Mercouri G. 
Published: June 2016

AbstractIntermetallic Hf3Fe4Sn4 (I) is obtained from the elements using excess Sn as flux (Al2O3 crucible in evacuated silica tubes, 1100 °C, 30 min; ≈70% yield).
ChemInform Abstract: Ligand‐Controlled Divergent C—H Functionalization of Aldehydes with Enynes by Cobalt Catalysts.
Authors: Santhoshkumar Rajagopal , Mannathan Subramaniyan , Cheng Chien‐Hong 
Published: June 2016

AbstractThe cobalt‐catalyzed reaction of 1,6‐enynes (I) with benzaldehyde leads either to aldehydes [cf.
ChemInform Abstract: Bifunctional Iminophosphorane Catalyzed Enantioselective Sulfa‐Michael Addition to Unactivated α‐Substituted Acrylate Esters.
Authors: Farley Alistair J. M. , Sandford Christopher , Dixon Darren J. 
Published: June 2016

AbstractA variety of chiral β‐mercaptoesters such as (III), (V), and (VII) is prepared by BIMP‐catalyzed enantioselective sulfa‐Michael addition of alkyl thiols (II) to acrylate esters.
ChemInform Abstract: A Practical Solution to Stereodefined Tetrasubstituted Olefins.
Authors: Dai Jianxin , Wang Minyan , Chai Guobi , Fu Chunling , Ma Shengming 
Published: June 2016

AbstractThis method allows the construction of a wide range of tetrasubstituted olefins with defined stereochemistry, which all bear an extremely versatile aldehyde functionality, via the conjugate addition of organozinc reagents to readily available 2,3‐ allenals.
ChemInform Abstract: Highly Diastereo‐/Enantioselective Cu‐Catalyzed Propargylic Alkylations of Propargyl Acetates with Cyclic Enamines
Authors: Zhang Cheng , Hui Yun‐Ze , Zhang De‐Yang , Hu Xiang‐Ping 
Published: June 2016

Abstractfor the construction of vicinal tertiary stereocenters employing a less sterically hindered chiral tridentate P,N,N‐ligand
ChemInform Abstract: Ligand‐Enabled, Copper‐Promoted Regio‐ and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers.
Authors: Singh Bijaya Kumar , Jana Ranjan 
Published: June 2016

AbstractA practical method for the ortho C—H hydroxylation of benzamides with inexpensive copper(II) acetate monohydrate and a pyridine ligand is presented.
ChemInform Abstract: Palladium‐Catalyzed N‐Arylsulfonamide Formation from Arylsulfonyl Hydrazides and Nitroarenes.
Authors: Zhao Feng , Li Bin , Huang Huawen , Deng Guo‐Jun 
Published: June 2016

AbstractThe nitroarenes are reduced by hydrogen in situ generated from the arylsulfonyl hydrazides and without external reducing agent.
ChemInform Abstract: KIO3‐Catalyzed Aerobic Cross‐Coupling Reactions of Enaminones and Thiophenols: Synthesis of Polyfunctionalized Alkenes by Metal‐Free C—H Sulfenylation.
Authors: Wan Jie‐Ping , Zhong Shanshan , Xie Lili , Cao Xiaoji , Liu Yunyun , Wei Li 
Published: June 2016

AbstractA new catalytic method for the α‐sulfenylation of enaminones and related enamines under environmentally benign conditions using ethyl lactate as bio‐based green solvent is developed.
ChemInform Abstract: A Facile Method for the Preparation of Unsymmetrical Ureas Utilizing Zirconium(IV) Chloride.
Authors: Lee Anna , Kim Hee‐Kwon , Thompson David H. 
Published: June 2016

AbstractZr‐mediated reaction of carbamoyl imidazole derivatives with primary or secondary amines gives unsymmetrical urea derivatives in good to excellent yields.
ChemInform Abstract: Organic/Inorganic Salting‐In/Salting‐Out Agents as Promoters of Pd‐Catalyzed Ligand Free Synthesis of Biaryls in Water.
Authors: Boruah Preeti Rekha , Bora Sankar Jyoti , Saikia Prakash J. , Sarma Diganta 
Published: June 2016

AbstractThe influence of organic/inorganic additives on the Pd‐catalyzed Suzuki—Miyaura cross‐coupling of aryl halides with arylboronic acids in water is discussed.
ChemInform Abstract: Access to Atropisomerically Enriched Biaryls by the Coupling of Aryllithiums with Arynes under Control by Homochiral Oxazolines.
Authors: Yalcouye Boubacar , Berthelot‐Brehier Anais , Augros David , Panossian Armen , Choppin Sabine , Chesse Matthieu , Colobert Francoise , Leroux Frederic R. 
Published: June 2016

AbstractCoupling of in situ generated aryllithiums with enantiopure aryloxazolines gives axially stereoenriched highly substituted biaryls.
ChemInform Abstract: Nickel—Glycerol: An Efficient, Recyclable Catalysis System for Suzuki Cross Coupling Reactions Using Aryl Diazonium Salts.
Authors: Bhojane Jeevan Manohar , Sarode Sachin Ashok , Nagarkar Jayashree Milind 
Published: June 2016

AbstractA wide range of diaryl compounds is efficiently synthesized through Suzuki reactions using NiCl2/DME as catalyst.
ChemInform Abstract: Functionalization of C(sp3)—H Bonds Using a Transient Directing Group.
Authors: Zhang Fang‐Lin , Hong Kai , Li Tuan‐Jie , Park Hojoon , Yu Jin‐Quan 
Published: June 2016

AbstractA wide range of aldehydes and ketones are arylated at the β‐ or γ‐position using a catalytic amount of amino acid.
ChemInform Abstract: Copper(I) Catalyzed Diastereoselective Multicomponent Synthesis of Spiroindolo‐pyrrolidines/‐imidazolidines/‐triazolidines from Diazoamides via Azomethine Ylides.
Authors: Muthusamy Sengodagounder , Kumar Singaravelan Ganesh 
Published: June 2016

AbstractThe novel method to synthesize highly substituted spiroindolo‐pyrrolidines/‐imidazolidines/‐triazolidines is efficiently catalyzed by Cu(I)TC.
ChemInform Abstract: Modular Catalytic Synthesis of 3‐Amino‐3‐aryl‐2‐oxindoles: Rh Catalysis with Isatin‐Derived N‐Boc‐Protected Ketimines.
Authors: Marques Carolina S. , Burke Anthony J. 
Published: June 2016

AbstractThe Rh‐catalyzed arylation of isatin‐derived N‐Boc ketimines with arylboronic acid produces 3‐aryl‐3‐amino‐2‐oxindoles in good yields.
ChemInform Abstract: Palladium‐Catalyzed Highly Atom‐Economical Allylation of Oxindoles with Vinyl Cyclopropanes.
Authors: Cao Ruwei , Zhang Jinlong , Zhou Hui , Yang Huameng , Jiang Gaoxi 
Published: June 2016

AbstractVinyl cyclopropanes can be utilized as very effective reactants in the Pd(0)‐catalyzed allylic alkylation for quickly assembling an all‐carbon quaternary allylic center at the 3‐position of oxindole in good yields and with excellent regioselectivities.
ChemInform Abstract: Visible‐Light Photoredox Intramolecular Difluoroacetamidation: Facile Synthesis of 3,3‐Difluoro‐2‐oxindoles from Bromodifluoroacetamides.
Authors: Wei Xiao‐Jing , Wang Lin , Du Shao‐Fu , Wu Li‐Zhu , Liu Qiang 
Published: June 2016

AbstractCatalytic and efficient method for the construction of 3,3‐difluoro‐2‐oxindoles via visible light photocatalysis is reported for the first time.
ChemInform Abstract: The Cooperative FeCl3/DDQ System for the Regioselective Synthesis of 3‐Arylindoles from β‐Monosubstituted 2‐Alkenylanilines.
Authors: Jang Su San , Youn So Won 
Published: June 2016

AbstractHighly regioselective synthesis of 3‐arylindoles by using the cooperative FeCl3/DDQ system, involving 1,2‐aryl migration is reported.
ChemInform Abstract: Synthesis, Conformation and Antiproliferative Activity of Isothiazoloisoxazole 1,1‐Dioxides.
Authors: Blackburn J. , Molyneux G. , Pitard A. , Rice C. R. , Page M. I. , Afshinjavid S. , Javid F. A. , Coles S. J. , Horton P. N. , Hemming K. 
Published: June 2016

AbstractTitle compounds (III) are prepared by 1,3‐dipolar cycloaddition of nitriloxides, generated in situ, from hydroxymoyl chloride (II), to isoxazole 1,1‐dioxides (I).
ChemInform Abstract: An Environmentally Benign One Pot Synthesis of Pyrazole Substituted‐2‐hydrazolyl‐4‐thiazolidinones.
Authors: Bhosle Manisha R. , Khillare Lalit D. , Dhumal Sambhaji T. , Mane Ramrao A. 
Published: June 2016

AbstractThe environmentally friendly ultrasound promoted method offers several advantages such as operational simplicity, easy work‐up procedure, shorter reaction times, and high yields.
ChemInform Abstract: Piperazinium Dihydrogen Sulfate: An Acidic Ionic Liquid for the [3 + 2] Cycloaddition Reaction of Sodium Azide with Organic Nitriles.
Authors: Nowrouzi Najmeh , Farahi Soghra , Irajzadeh Maryam 
Published: June 2016

AbstractVarious 5‐substituted tetrazoles are obtained under solvent‐free reaction conditions.
ChemInform Abstract: Oxidative C—H Activation Approach to Pyridone and Isoquinolone Through an Iron‐Catalyzed Coupling of Amides with Alkynes.
Authors: Matsubara Tatsuaki , Ilies Laurean , Nakamura Eiichi 
Published: June 2016

AbstractThe title compounds are synthesized by annulation of alkene‐ or areneamides with internal alkynes.
ChemInform Abstract: Dual Role of p‐Tosylchloride: Copper‐Catalyzed Sulfenylation and Metal Free Methylthiolation of Imidazo[1,2‐a]pyridines.
Authors: Ravi Chitrakar , Chandra Mohan Darapaneni , Adimurthy Subbarayappa 
Published: June 2016

AbstractA novel and efficient method for sulfenylation of imidazo[1,2‐a]pyridines using commercially available and environment‐friendly sources of sulfenylating agents, p‐tosylchloride and DMSO is reported.
ChemInform Abstract: γ‐Carboline AC190 Analogues via Palladium Catalyzed Allene Insertion Stereo and Regioselective 3‐ and 5‐Component Cascades.
Authors: Dondas H. Ali , Hempshall Aiden , Narramore Sarah , Kilner Colin , Fishwick Colin W. G. , Grigg Ronald 
Published: June 2016

AbstractPd‐Catalyzed three component reaction of pyrido[4,3‐b]‐5H‐indoles, allenes, and aryl iodides produces the title compounds regioselectively.
ChemInform Abstract: Peculiarities of 2‐Amino‐3‐R‐4‐aryl‐4H‐pyranes Multicomponent Synthesis Derived from 1H‐2,1‐Benzothiazin‐4(3H)‐one 2,2‐Dioxide.
Authors: Lega Dmitry A. , Gorobets Nikolay Yu. , Chernykh Valentine P. , Shishkina Svetlana V. , Shemchuk Leonid A. 
Published: June 2016

AbstractThree‐component reactions of benzothiazinone dioxide (I), benzaldehydes, and active methylene nitriles leading to the title pyrans are studied.
Optogenetic Control of Nuclear Protein Import in Living Cells Using Light‐Inducible Nuclear Localization Signals (LINuS)
Authors: Wehler Pierre , Niopek Dominik , Eils Roland , Di Ventura Barbara 
Published: June 2016

AbstractMany biological processes are regulated by the timely import of specific proteins into the nucleus. The ability to spatiotemporally control the nuclear import of proteins of interest therefore allows study of their role in a given biological process as well as controlling this process in space and time. The light‐inducible nuclear localization signal (LINuS) was developed based on a natural plant photoreceptor that reversibly triggers the import of proteins of interest into the nucleus with blue light. Each LINuS is a small, genetically encoded domain that is fused to the protein of interest at the N or C terminus. These protocols describe how to carry out initial microscopy‐based screening to assess which LINuS variant works best with a protein of interest. © 2016 by John Wiley & Sons, Inc.
Confined Water in Amyloid‐Competent Oligomers of the Prion Protein
Authors: Dalal Vijit , Arya Shruti , Mukhopadhyay Samrat 
Published: June 2016

AbstractConformational switching of the prion protein into the abnormal form involves the formation of (obligatory) molten‐oligomers that mature into ordered amyloid fibrils. The role of water in directing the course of amyloid formation remains poorly understood. Here, we show that the mobility of the water molecules within the on‐pathway oligomers is highly retarded. The water relaxation time within the oligomers was estimated to be ≈1 ns which is about three orders of magnitude slower than the bulk water and resembles the characteristics of (trapped) nano‐confined water. We propose that the coalescence of these obligatory oligomers containing trapped water is entropically favored because of the release of ordered water molecules in the bulk milieu and results in the sequestration of favorable inter‐chain amyloid contacts via nucleated conformational conversion. The dynamic role of water in protein aggregation will have much broader implications in a variety of protein misfolding diseases.
Direct Evidence of CO2 Capture under Low Partial Pressure on a Pillared Metal–Organic Framework with Improved Stabilization through Intramolecular Hydrogen Bonding
Authors: Yao Zizhu , Chen Yuan , Liu Lizhen , Wu Xiaonan , Xiong Shunshun , Zhang Zhangjing , Xiang Shengchang 
Published: June 2016

AbstractDirect structural observation of CO2‐loaded MOFs is helpful for revealing the specific binding interactions to allow the design of better CO2 sorbents, but such direct structural evidence is almost always observed for pure‐component CO2 under a pressure of 1 atm or more, which does not really represent practical CO2 capture and separation under low partial pressure (≤1 atm) in the presence of other gases. Herein, a series of isoreticular MOFs [Zn(Trz)(R‐BDC)1/2] (FJU‐40‐R, R=H, NH2, Br, or OH) are synthesized. Among them, FJU‐40‐NH2 exhibits the highest robustness, and good heat and water resistance, attributed to its intramolecular hydrogen‐bonding interactions. A CO2/N2 (15:85, v/v) mixture can be separated efficiently through a column packed bed of FJU‐40‐NH2 solid. The structures of CO2‐loaded FJU‐40‐NH2 at 1 atm under various atmosphere conditions, including pure CO2, CO2/N2 (15:85, v/v), and air, are observed, and it is found that: 1) the mechanism for CO2 loading into the cages depends on the CO2 partial pressure; 2) FJU‐40‐NH2 can capture CO2 directly from air, and CO2 will have priority to occupy hydrophobic cage‐I, whereas hydrophilic cage‐II containing the amino group is occupied by H2O molecules; 3) the triazolate C−H groups, rather than the amino groups in past observations in dry ice, act as predominant functional sites here under low CO2 partial pressure.
Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL‐KrasG12D/+;LSL‐Trp53R172H/+;Pdx‐1‐Cre), Its Variants, and Their Application in Immuno‐oncology Drug Discovery
Authors: Lee Jae W. , Komar Chad A. , Bengsch Fee , Graham Kathleen , Beatty Gregory L. 
Published: June 2016

AbstractPancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer‐related deaths in the United States. For patients with unresectable disease, treatment options are limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate the biology of human pancreatic cancer offer an opportunity for the rational development of novel treatment approaches that may improve patient outcomes. With the recent success of immunotherapy for subsets of patients with solid malignancies, interest is mounting in the possible use of immunotherapy for the treatment of PDAC. Considered in this unit is the value of genetic mouse models for characterizing the immunobiology of PDAC and for investigating novel immunotherapeutics. Several variants of these models are described, all of which may be used in drug development and for providing information on unique aspects of disease biology and therapeutic responsiveness. © 2016 by John Wiley & Sons, Inc.
Commentary: Mitochondrial DNA damage and loss in diabetes
Authors: Gilkerson Robert 
Published: June 2016

AbstractThis commentary discusses damage and loss of mitochondrial DNA (mtDNA) in type 2 diabetes mellitus from both the clinical and experimental perspectives. Increasingly, an array of studies in experimental models and patients suggests that the cellular stresses of insulin resistance in type 2 diabetes damage mtDNA, leading to loss of mitochondrial genetic content. As such, mtDNA is emerging as both a valuable monitoring tool and translational preventive target for metabolic disease. Copyright © 2016 John Wiley & Sons, Ltd.