bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIGN ZOLMITRIPTAN LIQUISOLID ORODISPERSIBLE TABLETS AND THEIR IN VITRO EVALUATION
Authors: Egla Mustafa , Hammid Shaimaa N. Abd Al 
Published: February 2017

<p><strong>Objective: </strong>The objective of present study is to develop orodispersible tablets (ODTs) of zolmitriptan by liquisolid technique using different types of super disintegrants to enhance the disintegration and dissolution of zolmitriptan to improve the bioavailability of the drug.</p><p><strong>Methods: </strong>Liquisolid ODTs of zolmitriptan were prepared from; microcrystalline cellulose (Avicel PH-102) as carrier, colloidal silicon dioxide (Aerosil 200) as a coating material, croscarmellose sodium (CSS), sodium starch glycolate (SSG), and crospovidone (CP) as super disintegrants, and propylene glycol as liquid vehicle. The ratio of carrier to coating material was kept constant in all formulations at 35:1, this ratio was chosen after testing the ratios 10:1, 15:1, 20:1, 25:1,30:1, and 35:1. The ratio 35:1 give optimal results relative to other ratios. The pre-compression evaluation includes: flow properties were measured using the angle of repose and the compressibility index and FT-IR. The prepared liquid-solid system compacts were evaluated for their post-compression evaluation which includes: hardness, friability, wetting time, <em>in vitro</em> disintegration time, drug content and <em>in vitro</em> drug release.</p><p><strong>Results: </strong>The tabletting properties of the liquid-solid ODTs were within the acceptable limits. Among the three super disintegrants, CP found to be the best in term of showing the fastest disintegration time. The optimized selected formula (F11) was prepared using 5% w/w crospovidone, by direct compression showed the shortest disintegration time (24 s), superior drug release profile [ the time required for 80% of the drug to be released (T<sub>80</sub>%) and percent drug dissolved in 2 min (D<sub>2 </sub>min) 1.84 min and 87.59%, respectively]. In addition to that, the selected formula had an acceptable hardness and friability, so it was selected as the best formula.</p><p><strong>Conclusion: </strong>The overall results showed that CP was the best super disintegrant of showing the shortest disintegration time while loading factor of 0.125 was the best in the preparing of zolmitriptan liquid-solid ODTs, and this suggested the possibility of utilizing the selected best formula (F11) in the preparation of zolmitriptan ODTs as a new dosage form for oral administration. </p>
PHYTOCHEMICAL ANALYSIS OF SECONDARY METABOLITES OF SATUREJA HORTENSIS L.
Authors: Shanaida Mariya , Ivanusa Iryna , Kernychna Ivanna 
Published: February 2017

<p><strong>Objective: </strong>The present study was designated to analyse the essential oils and tannins as important secondary metabolites of the aerial part of <em>Satureja hortensis</em>.</p><p><strong>Methods: </strong>The chemical composition of <em>S</em><em>. </em><em>hortensis</em> herb was investigated using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). The essential oil was obtained by hydrodistillation method.</p><p><strong>Results: </strong>The essential oil yield in the aerial part of<em> </em><em>S</em><em>. </em><em>hortensis</em><strong> </strong>was 1.61%. GC-MS analysis of the essential oils identified the presence of 29 components. Carvacrol (76.16%), as the main component of essential oils, belongs to the group of aromatic compounds. Eight tannin components identified by HPLC and epigallocatechin (130.91х10<sup>-2</sup>%) are prevalent among them.</p><p><strong>Conclusion</strong>:<strong> </strong><em>S. hortensis</em> was found to possess considerable amount of phytoconstituents such as essential oils and tannins. The results of this research will help to study pharmacological properties of the investigated plant and to prevent possible adulteration with other plants.</p>
PENGEMBANGAN KAMUS ”CHART OF ACCOUNTS” UNTUK MATA KULIAH AKUNTANSI PERHOTELAN
Authors: Gede Diatmika I Putu 
Published: February 2017

Akuntansi Perhotelan merupakan salah satu mata kuliah akuntansi terapan dalamkondisi riil di dunia kerja tepatnya implementasi di dunia pariwisata. Mata kuliah ini memilikikarakteristik yang berbeda dengan dunia usaha lainnya terutama terkait dengan sifat usahaberupa kegiatan jasa pelayanan ”hospitality service” yang berorientasi profit. Chart OfAccounts dalam akuntansi perhotelan merupakan rekening-rekening Akuntansi serta istilahistilahyang merupakan komponen penting dalam penguasaan Akuntansi Perhotelan.Rekening dan istilah dalam akuntansi perhotelan sangatlah berbeda dengan akuntansisecara umum terlebih lagi saat ini informasi mengenai chart of Accounts ini belum terkoordinasi dalam satu literatur yang tepat. Tujuan jangka panjang dari penelitian iniadalah untuk menghasilkan literatur dalam bentuk kamus Chart Of Accounts untuk Akuntansi Perhotelan yang dapat dimanfaatkan dalam pembelajaran Akuntansi Perhotelandi kelas yang sekaligus juga dapat dimanfaatkan sebagai sumber informasi pemakai baikmasyarakat umum maupun praktisi di di dunia perhotelan. Untuk dapat mencapai tujuan penelitian ini digunakan model pengembangan four D Models yang terdiri dari 4 tahappengembangan, yaitu Define, Design, Develop, dan Desseminate. Produk penelitian iniadalah kamus Chart of Accounts untuk Akuntansi Perhotelan.
KESELAMATAN OLAHRAGA MELALUI BUKU PEDOMAN KESELAMATAN DALAM OLAHRAGA
Authors: Dharmadi Made Agus 
Published: February 2017

Penelitian ini bertujuan untuk penyempurnaan dan mensosialisasikan buku pedoman yang telah dikembangkan sebelumnya, melalu uji pakar dan uji praktisi, yang terdiri dari pakar olahraga, pakar kesehatan dan pakar buku pedoman. Sedangkan uji praktisi dilakukan oleh guru-guru di jenjang SD, SMP dan SMA dengan minimal memiliki kualifikasi Master. Metode yang digunakan dalam penelitian ini adalah metode pengembangan menurut Gall and Gall (2003:570), teknik pengumpulan data yang digunakan adalah menggunakan teknik kuesioner kepada para pakar dan praktisi melalui form penilaian, sedangkan analisis data yang digunakan yaitu analisis deskriptif kualitatif. Berdasarkan hasil dan pembahasan yang dilakukan, maka dapat disimpulkan bahwa keberadaan buku pedoman keselamatan olahraga sebagai panduan ataupun petujuk praktis terhadap upaya pencegahan terhadap resiko kecelakaan dalam pembelajaran penjasorkes sangat penting bagi guru/pelatih dan siswa. Buku pedoman diharapkan dapat dikembangkan segera dan dicetak dalam bentuk buku ataupun booklet yang mudah digunakan, sehingga diharapkan nantinya dapat menunjang penampilan siswa/atlet dalam proses belajar/berlatihnya, disamping itu pula, pengembangan buku pedoman keselamatan olahraga memiliki asas manfaat yang baik berdasarkan hasil sosialisasi kepada siswa-siswa yang akan menggunakan buku pedoman tersebut. Dari kesimpulan ini, dapat disarankan agar buku yang telah di uji pakar maupun praktisi ini dapat dicetak dan sebarkan kepada guru/dosen, pelatih, siswa/mahasiswa dan juga masayarakat umum untuk dimanfaatkan sebagai buku utama dalam pencegahan aktifitas berolahraga.
BALINISASI MASAKAN VEGETARIAN
Authors: Suja I Wayan , Retug Nyoman 
Published: February 2017

Kesadaran masyarakat untuk beralih kepada makanan alami, termasuk makanan vegetarian, sesungguhnya memberikan peluang bisnis bagi mereka yang bergerak dalam bidang usaha kuliner. Peluang tersebut semula hanya dimanfaatkan oleh warga keturunan dengan menyediakan masakan Cina, yang selain terasa aneh di lidah, juga tergolong mahal. Untuk itu, dipandang perlu untuk membalinisasi masakan vegetarian bekerja sama dengan mitra lokal yang bergerak dalam bidang usaha kuliner vegetarian. Dua mitra telah dilibatkan, yaitu Depot Vegetarian Bhoga Laksmi dan Depot Vegetarian Bu Krisna, yang masing-masing berlokasi di sebelah Timur dan Barat kota Singaraja, Bali. Dari wawancara dan observasi awal ditemukan bahwa kedua mitra masih perlu diberikan pemahaman berkaitan dengan seluk-beluk vegetarian dan dilatih membuat masakan vegetarian khas Bali, termasuk penggunaan bumbu-bumbu Bali (basa genep). Kegiatan IbM ini dilaksanakan untuk meningkatkan pemahaman dan keterampilan mitra dalam membuat masakan vegetarian dengan nuansa Bali menggunakan bahan-bahan dan bumbu lokal dan alami. Kegiatan dilakukan dengan metode pelatihan, yang meliputi diskusi dan praktek. Hasil kegiatan berupa pemahaman dan kemampuan mitra untuk mengkomunikasikan makanan vegetarian semakin mantap, serta terampil membalinisasi masakan vegetarian. Masakan vegetarian yang dihasilkan dalam kegiatan IbM ini memiliki karakteristik sebagai berikut. Pertama, jenis masakannya mengikuti makanan tradisional Bali atau sudah diadaptasi dalam khasanah budaya kuliner Bali. Jenis-jenis masakan tersebut, meliputi lawar, tum, sate, urutan, be siap sitsit, be kuah, rawon, ati, syobak, plecing, dan lain-lainnya. Kedua, menurut konsumen tekstur masakan vegetarian yang dibuat sudah sangat mirip dengan masakan produk daging hewani. Ketiga, bumbu yang digunakan merupakan produk sendiri menggunakan bahan-bahan alami lokal. Penggunaan bumbu lokal tersebut (terutama basa gede/basa genep) menyebabkan masakan vegetarian yang dihasilkan memiliki aroma dan rasa sesuai dengan selera masyarakat Bali. Ketiga spesifikasi tersebut merupakan keunggulan masakan vegetarian khas Bali yang dihasilkan, sebagai produk usaha kreatif untuk membalinisasi masakan vegetarian. Inovasi produk dan peningkatan pelayanan kepada pelanggan telah berdampak positif terhadap penghasilan harian mereka. Semula penghasilan per hari kedua mitra masing-masing berkisar antara Rp.150 – 200 ribu, setelah pelatihan mencapai Rp. 275 – 400 ribu rupiah.
DESA BINAAN BERBASIS KEARIFAN LOKAL TRI HITA KARANA DI DESA PEMUTERAN KECAMATAN GEROKGAK KABUPATEN BULELENG
Authors: Mudana I Wayan 
Published: February 2017

Pengabdian Kepada masyarakat ini bertujuan untuk (1) meningkatkan wawasan aparat desa dalam berkolaborasi dengan kelompok masyarakat ekonomi, politik dan sipil, (2) meningkatkan pengetahaun dan keterampilan ibu-ibu PKK di Desa Pemuteran dalam mengolah ikan hasil tangkapan, (3) meningkatkan pengetahaun dan keterampilan ibu- ibu PKK di Desa Pemuteran dalam mengolah ubi ketela pohon dalam membuat beraneka kue kukus, dan (4)meningkatkan wawasan aparat desa, ibu-ibu PKK dan anggota masyarakat tentang pariwisata dan pelestarian lingkungan. Kegiatan ini dilaksanakan dengan metode ceramah, diskusi dan pelatihan. Melalui kegiatan ini dihasilkan peningkatan pengetahuan aparat desa dalam mengembangkan kolaborasi dengan kelompok masyarakat lainnya seperti masyarakat politik, ekonomi dan sipil, peningkatan pengetahuan dan keterampilan aparat desa dan Ibu-Ibu PKK dalam pengembangan pariwisata dan kelestarian lingkungan, peningkatan wawasan dan keterampilan ibu-ibu PKK pembuatan bakso, nugget dan bolu kukus pelangi.
PELATIHAN PENULISAN ARTIKEL ILMIAH BAGI GURU-GURU KIMIA DI KABUPATEN BULELENG
Authors: Redhana I Wayan 
Published: February 2017

Tujuan kegiatan P2M ini adalah menghasilkan produk berupa artikel ilmiah yang siap diterbitkan dalam Jurnal Pendidikan Kimia Indonesia (JPKimIa) melalui pelatihan. Kegiatan pelatihan yang dilakukan meliputi berkoordinasi dengan MGMP Kimia Kabupaten Buleleng mengenai jadwal dan tempat pelaksanaan P2M, pelatihan pencarian informasi atau browsing internet, pembekalan penulisan artikel ilmiah, pelatihan menganalisis artikel jurnal yang telah dipublikasikan, dan pembuatan artikel ilmiah. Jumlah peserta kegiatan sebanyak 30 orang guru-guru kimia. Hasil kegiatan P2M adalah guru-guru kimia sangat antusias mengikuti pelatihan P2M.
PENGEMBANGAN PROFESIONALISME GURU MELALUI PELATIHAN PENYUSUNAN KARYA TULIS ILMIAH DI WILAYAH PEDALAMAN
Authors: Annisa Muhsinah , Hamid Hariyati , - Kartini 
Published: February 2017

Kecamatan Long Pujungan Kabupaten Malinau merupakan salah satu daerah di provinsi Kalimatan Utara (Kaltara) yang termasuk wilayah pedalaman. Malinau berbatasan langsung dengan negara tetangga, yaitu Sabah, Malaysia Timur. Sebagai daerah yang berbatasan langsung dengan negara lain. Guru profesional harus memiliki 4 kompetensi, salah satunya yaitu kompetensi profesional. Berdasarkan wawancara dengan guru-guru di SDN 001 Long Pujungan, ditemukan permasalah yaitu banyak guru yang mengalami kendalal dalam kenaikan pangkat, salah satunya dikarenakan minimnya publikasi karya ilmiah. Hal ini disebabkan oleh pemahaman guru belum memadai dalam penyusunan karya tulis ilmiah. Pelatihan Pengabdian Masyarakat menggunakan metode yang digunakan adalah ceramah, penugasan dan diskusi serta pendampingan pembuatan karya tulis ilmiah dan perangkat pembelajaran. Langkah-langkah kegiatan yaitu dengan pelatihan berupa teori, penugasan secara mandiri dan diskusi. Sasaran kegiatan ini adalah guru-guru sekolah dasar di Kecamatan Long Pujungan Kabupaten Malinau. Data angket yang diberikan kepada peserta menunjukkan bahwa 100% merupakan hal yang baru, 84 % pelatihan ini sangat membantu dalam pelaksanaan, 88% peserta memperoleh tambahan pengetahuan dan keterampilan,12% masih tidak mengerti. 96% peserta menjawab bahwa guru memerlukan referensi dalam pelaksanaan tugas, Dalam ketersediaan referensi, 92% menyatakan bahwa referensi ada di tempat mereka bekerja, tapi belum mencukupi. 100% peserta menyatakan bahwa petihan sangat efektf. dan 100% menyatakan perlu ada pelatihan lanjutan.
Clinical Effectiveness and Tolerability of Electroconvulsive Therapy in Patients with Neuropsychiatric Symptoms of Dementia
Authors: Isserles Moshe , Daskalakis Zafiris J. , Kumar Sanjeev , Rajji Tarek K. , Blumberger Daniel M. 
Published: February 2017

Background: Dementia frequently presents with aggression, agitation, and disorganized behavior for which current treatment is partially effective and is associated with significant adverse effects. Objective: The aim of this study was to retrospectively assess the clinical effectiveness and tolerability of electroconvulsive therapy (ECT) in a sample of patients with neuropsychiatric symptoms of dementia (NPS) and to explore factors associated with response and with cognitive adverse effects. Methods: We examined the clinical records of 25 patients with dementia and a pre-existing psychiatric disorder treated with ECT at an academic mental health hospital between April 1, 2010 and January 28, 2016. Twenty-nine acute ECT courses and fifteen maintenance courses were reviewed. We assessed treatment effectiveness and cognitive adverse effects as well as factors associated with response to treatment, including pre-existing psychiatric disorders, concomitant pharmacological treatment and types of dementia. Results: ECT resulted in a clinically meaningful response in 72% of acute treatment courses. Cognitive adverse effects affecting functioning were reported in 7% of the acute treatment courses. Maintenance treatment was effective in sustaining the response in 87% of treatment courses with two reports of significant cognitive adverse effects. One patient fell and experienced a hip fracture a day after treatment. Use of antipsychotic or antidepressant medications, pre-existing psychiatric disorder, or gender were not associated with response. Conclusion: This study shows meaningful clinical effectiveness and good tolerability of ECT in patients with severe NPS of dementia. Furthermore, maintenance ECT was effective in sustaining treatment response.
The Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Late-Onset Alzheimer’s disease: Further Evidence in an Italian Multicenter Study
Authors: Stoccoro Andrea , Tannorella Pierpaola , Salluzzo Maria Grazia , Ferri Raffaele , Romano Corrado , Nacmias Benedetta , Siciliano Gabriele , Migliore Lucia , Coppedè Fabio 
Published: February 2017

Background: A functional polymorphism in the methylenetetrahydrofolate reductase ( MTHFR) gene, namely C677T (rs1801133), results in increased Hcy levels and has been associated with risk of late-onset Alzheimer’s disease (LOAD). Many investigators reported association between rs1801133 and LOAD risk in Asian populations and in carriers of the apolipoprotein E ( APOE) ɛ4 allele, but recent meta-analyses suggest a contribution also in other populations, including Caucasians and/or northern Africans. Objective: To further address this issue, we performed a relatively large case-control study, including 581 LOAD patients and 468 matched controls of Italian origin. APOE data were available for a subgroup of almost 600 subjects. Methods: Genotyping for rs1801133 was performed with PCR-RFLP techniques. Results: In the total population, the MTHFR 677T allele (OR = 1.20; 95% CI = 1.01–1.43) and carriers of the MTHFR 677T allele (CT+TT versus CC: OR = 1.34; 95% CI = 1.03–1.73) resulted in increased LOAD risk. Similarly, in APOE ɛ4 carriers, we observed an increased frequency of MTHFR 677CT carriers (CT versus CC: OR = 2.82; 95% CI = 1.25–6.32). Very interestingly, also in non- APOE ɛ4 carriers, both MTHFR 677T allele (OR = 1.38; 95% CI = 1.03–1.85) and MTHFR 677TT genotype (OR = 2.08; 95% CI = 1.11–3.90) were associated with LOAD. All these associations survived after corrections for age, gender, and multiple testing. Conclusions: The present results suggest that the MTHFR C677T polymorphism is likely a LOAD risk factor in our cohort, either in APOE ɛ4 or in non- APOE ɛ4 carriers.
Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
Authors: Balietti Marta , Giuli Cinzia , Fattoretti Patrizia , Fabbietti Paolo , Papa Roberta , Postacchini Demetrio , Conti Fiorenzo 
Published: February 2017

A comprehensive intervention (CI) on patients with Alzheimer’s disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cogscore) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cogscore decreased significantly. At FU2 and FU3, patients’ cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.
The Impact of Alzheimer’s Disease on the Resting State Functional Connectivity of Brain Regions Modulating Pain: A Cross Sectional Study
Authors: Monroe Todd B. , Beach Paul A. , Bruehl Stephen P. , Dietrich Mary S. , Rogers Baxter P. , Gore John C. , Atalla Sebastian W. , Cowan Ronald L. 
Published: February 2017

Background: It is currently unknown why people with Alzheimer’s disease (AD) receive less pain medication and report pain less frequently. Objective: The purpose of this study was to determine the impact of AD on thermal psychophysics and resting-state functional connectivity (RSFC) among sensory, affective, descending modulatory, and default mode structures. Methods: Controls ( n = 23, 13 = female) and age-matched people with AD ( n = 23, 13 = females) underwent psychophysical testing to rate perceptions of warmth, mild, and moderate pain and then completed resting-state fMRI. Between groups analysis in psychophysics and RSFC were conducted among pre-defined regions of interest implicated in sensory and affective dimensions of pain, descending pain modulation, and the default mode network. Results: People with AD displayed higher thermal thresholds for warmth and mild pain but similar moderate pain thresholds to controls. No between-group differences were found for unpleasantness at any percept. Relative to controls, people with AD demonstrated reduced RSFC between the right posterior insula and left anterior cingulate and also between right amygdala and right secondary somatosensory cortex. Moderate pain unpleasantness reports were associated with increased RSFC between right dorsolateral prefrontal cortex and left ACC in controls only. Conclusions: While AD had little effect on unpleasantness, people with AD had increased thermal thresholds, altered RSFC, and no association of psychophysics with RSFC in pain regions. Findings begin to elucidate that in people with AD, altered integration of pain sensation, affect, and descending modulation may, in part, contribute to decreased verbal pain reports and thus decreased analgesic administration.
Prevalence of Use of Cardiovascular Drugs in Dementia Patients Treated in General Practices in Germany
Authors: Jacob Louis , Bohlken Jens , Kostev Karel 
Published: February 2017

Background: Dementia is a chronic disease associated with numerous cardiovascular disorders. Objective: To analyze the prevalence of cardiovascular drug use in dementia patients treated in general practices in Germany. Methods: The present study included patients who were diagnosed with dementia (Alzheimer’s disease, vascular dementia, or unspecified dementia) in 2015. The main outcome measure was the proportion of patients using cardiovascular drugs. Demographical and clinical variables included age, sex, dementia type, and cardiovascular co-diagnoses. A multivariate logistic regression model was used to analyze the association between cardiovascular drug use and these variables. Results: We identified 7,987 and 1,268 dementia patients with and without prescriptions for cardiovascular drugs, respectively. The share of individuals who received cardiovascular treatments was 86.3%. Diuretics (20.9%), beta blocking agents (20.0%), and ACE inhibitors (17.4%) were the three most commonly prescribed types of medications. Patients between the ages of 71–80 (OR = 1.59), 81–90 (OR = 1.61), and over 90 years (OR = 1.48) were more likely to receive cardiovascular drugs than patients under the age of 70 years. Moreover, compared to those with unspecified dementia, individuals with Alzheimer’s disease had a lower chance while those with vascular dementia had a higher chance of being prescribed these drugs (ORs equal to 0.81 and 1.22, respectively). Finally, we found a positive association between the use of cardiovascular drugs and all co-diagnoses (ORs ranging from 1.23 to 7.12). Conclusion: The prevalence of cardiovascular drug use in dementia patients was around 86%. This use was significantly associated with such factors as age, type of dementia, and co-diagnoses.
Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening
Authors: Smith Robert A. , Andrews Kimberly S. , Brooks Durado , Fedewa Stacey A. , Manassaram‐Baptiste Deana , Saslow Debbie , Brawley Otis W. , Wender Richard C. 
Published: February 2017

ABSTRACTAnswer questions and earn CME/CNEEach year, the American Cancer Society publishes a summary of its guidelines for early cancer detection, data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, the authors summarize current American Cancer Society cancer screening guidelines, describe an update of their guideline for using human papillomavirus vaccination for cancer prevention, describe updates in US Preventive Services Task Force recommendations for breast and colorectal cancer screening, discuss interim findings from the UK Collaborative Trial on Ovarian Cancer Screening, and provide the latest data on utilization of cancer screening from the National Health Interview Survey. CA Cancer J Clin 2017;67:100–121. © 2017 American Cancer Society.