bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of proton pump inhibitors and dual antiplatelet therapy cessation on outcomes following percutaneous coronary intervention: Results From the PARIS Registry
Authors: Chandrasekhar Jaya , Bansilal Sameer , Baber Usman , Sartori Samantha , Aquino Melissa , Farhan Serdar , Vogel Birgit , Faggioni Michela , Giustino Gennaro , Ariti Cono , Colombo Antonio , Chieffo Alaide , Kini Annapoorna , Saporito Richard , Michael Gibson C. , Witzenbichler Bernhard , Cohen David , Moliterno David , Stuckey Thomas , Henry Timothy , Pocock Stuart , Dangas George , Gabriel Steg P. , Mehran Roxana 
Published: September 2016

BackgroundProton pump inhibitors (PPI) may decrease the availability of clopidogrel by competitive antagonism, leading to a potential increase in ischemic events.MethodsWe evaluated patients from the all‐comer PARIS registry treated with dual antiplatelet therapy (DAPT) with aspirin and clopidogrel following coronary stenting for outcomes stratified by PPI use. Two‐year major adverse cardiovascular events (MACE), composite of cardiac death, myocardial infarction, definite or probable stent thrombosis or target lesion revascularization (TLR), and net adverse cardiac events (NACE), composite of MACE or Bleeding Academic Research consortium (BARC) type 3 or 5 bleeding were assessed. We also explored associations between PPI use and patterns of 2‐year DAPT cessation.ResultsThe cohort comprised 4635 patients (23% PPI users) with mean age 64.4 ±11.4 years. Two year adjusted risk of MACE (HR: 1.27, 95% CI: 1.04–1.55), NACE (HR: 1.21, 95% CI: 1.01–1.44) and TLR (HR: 1.33, 95% CI: 1.04–1.71) were significantly higher in PPI users vs. non‐users, without a difference in bleeding. Although the incidence of 2‐year DAPT discontinuation and interruption was similar, DAPT disruption was significantly lower among PPI users vs. non‐users (10.0% vs. 14.7%, P <0.0001). Compared to non‐PPI users on continued DAPT, disruption was associated with higher MACE in both PPI users (HR: 2.34, 95% CI: 1.38–3.97) and non‐users (HR: 1.41, 95% CI: 1.02–1.94) but greater BARC 3,5 bleeding only in non‐PPI users (HR: 2.06, 95% CI: 1.21–3.51).ConclusionsIn clopidogrel treated PCI patients, the 2‐year adjusted risk of MACE and NACE was significantly higher in PPI users driven by higher TLR compared to non‐PPI users, without a difference in bleeding. PPI use was associated with lower incidence of DAPT disruption without an increase in disruption related bleeding compared to non‐PPI users on DAPT. © 2016 Wiley Periodicals, Inc.
Clinical outcomes of percutaneous coronary intervention in patients turned down for surgical revascularization
Authors: Sukul Devraj , Seth Milan , Dixon Simon R. , Zainea Mark , Slocum Nicklaus K. , Pielsticker Elizabeth J. , Gurm Hitinder S. 
Published: September 2016

ObjectivesWe examined clinical outcomes following percutaneous coronary intervention (PCI) in patients turned down for surgical revascularization across a broad population.BackgroundPrior studies suggest that surgical ineligibility is associated with increased mortality in patients with unprotected left main or multivessel coronary artery disease undergoing PCI.MethodsThis study included consecutive patients who underwent PCI in a multicenter registry in Michigan from January 2010 to December 2014. Surgical ineligibility required documentation indicating that a cardiac surgeon deemed the patient ineligible for surgery. In‐hospital outcomes included mortality (primary outcome), cardiogenic shock, cerebrovascular accident, contrast‐induced nephropathy (CIN), and a new requirement for dialysis (NRD).ResultsOf 99,370 patients at 33 hospitals with on‐site surgical backup, 1,922 (1.9%) were surgically ineligible. The rate of ineligibility did not vary by hospital (range: 1.5–2.5%; P = 0.79). Overall, there were no major differences in baseline characteristics or outcomes between surgically ineligible patients and the rest (i.e., nonineligible patients): mortality (0.52% vs. 0.52%; P > 0.5), cardiogenic shock (0.68% vs. 0.73%; P > 0.5), cerebrovascular accident (0.05% vs. 0.19%; P = 0.28), NRD (0.16% vs. 0.19%; P > 0.5), CIN (2.7% vs. 2.3%; P = 0.27). Among 1,074 patients who underwent unprotected left main PCI, 20 (1.9%) were surgically ineligible and experienced increased rates of mortality (20.0% vs. 5.3%; P = 0.022; adjusted OR = 7.38; P < 0.001) and other complications as compared to the remainder.ConclusionsPCI in a broad population of surgically ineligible patients is generally safe. However, among patients who underwent unprotected left main PCI, those deemed surgically ineligible experienced significantly worse outcomes as compared to the rest. © 2016 Wiley Periodicals, Inc.
Chemoselective Transfer Hydrogenation of Aldehydes with HCOONH4 Catalyzed by RuCl(CNNPh)(PP) Pincer Complexes
Authors: Baldino Salvatore , Facchetti Sarah , Nedden Hans Günter , Zanotti‐Gerosa Antonio , Baratta Walter 
Published: September 2016

AbstractAldehydes were chemoselectively reduced to primary alcohols by using HCOONH4 as the hydrogen donor through transfer hydrogenation catalyzed by benzo[h]quinoline pincer complexes RuCl(CNNPh)(PP) at substrate to catalyst molar ratios of 2000 to 20 000. This practical reaction performed with aldehydes of commercial‐grade purity in a water/toluene biphasic system afforded alcohols without the formation of condensation or amination side products.
Preparation of a New Carbon Nanofiber as a High‐Capacity Air Electrode for Nonaqueous Lithium–Oxygen Batteries
Authors: Xu Chunyang , Dai Jicui , Teng Xiangguo , Zhu Yongming 
Published: September 2016

AbstractA new carbon nanofiber codoped with nitrogen and phosphorus (NPCNF) that has a high specific surface area and good electrocatalytic properties for the oxygen reduction reaction (ORR) was synthesized using a template‐free method. The fabrication process involves the pyrolysis of phytic acid doped polyaniline aerogel. A nonaqueous Li‐O2 battery with a specific capacity as high as 12 607 mA h g−1 was constructed by using an oxygen electrode based on NPCNFs supported by Ni foam. The NPCNF electrode showed a lower overpotential than pure carbon. The observed excellent electrochemical performance could be because of the unique foamlike N‐ and P‐codoped carbon microstructure, which had a high ORR catalytic activity. These results indicate that the use of NPCNF as a cathode material could be a feasible approach to obtain a high‐capacity Li–O2 battery.
Electrochemical Impedance Spectroscopy at Well‐Controlled dc Bias for Nanoporous Platinum Microelectrodes in Rat Embryo Brain
Authors: Kim Beom Jin , Kim Yang‐Rae , Seo Minjee , Kim Eun Joong , Jeon Joohee , Chung Taek Dong 
Published: September 2016

AbstractNanoporous Pt with extremely small (1–2 nm) and uniform nanopores, L2‐ePt, is electrochemically investigated in rat embryo brain. In a comparative study under precise control of electrochemical potential, an electrochemical cell beneath the brain surface is constructed by introducing flat and nanoporous Pt twisted wires around which Ag/AgCl is wound. L2‐ePt and flat Pt in the brain are compared with each other by conventional voltammetry and electrochemical impedance spectroscopy at the dc bias, which is carefully selected to minimize faradaic interference. The electrochemical behavior at L2‐ePt implanted into embryo brain is immune to severe passivation and is closer to an ideal capacitor than flat Pt. A lower electrode impedance of L2‐ePt leads to less potential drop at the interface between the electrode and the extracellular solution, protecting the implanted system from unwanted faradaic reactions. Various aspects, including the low electrode impedance and electrochemical stability in embryo brain, suggest that L2‐ePt is a promising electrode material for effectively stimulating distant neuronal cells and recording local field potential signals.
Dynamical Bifurcation in Gas‐Phase XH− + CH3Y SN2 Reactions: The Role of Energy Flow and Redistribution in Avoiding the Minimum Energy Path
Authors: Proenza Yaicel G. , de Souza Miguel A. F. , Longo Ricardo L. 
Published: September 2016

AbstractThe gas‐phase reactions of XH− (X=O, S) + CH3Y (Y=F, Cl, Br) span nearly the whole range of SN2 pathways, and show an intrinsic reaction coordinate (IRC) (minimum energy path) with a deep well owing to the CH3XH⋅⋅⋅Y− (or CH3S−⋅⋅⋅HF) hydrogen‐bonded postreaction complex. MP2 quasiclassical‐type direct dynamics starting at the [HX⋅⋅⋅CH3⋅⋅⋅Y]− transition‐state (TS) structure reveal distinct mechanistic behaviors. Trajectories that yield the separated CH3XH+Y− (or CH3S−+HF) products directly are non‐IRC, whereas those that sample the CH3XH⋅⋅⋅Y− (or CH3S−⋅⋅⋅HF) complex are IRC. The IRCIRC/non‐IRC ratios of 90:10, 40:60, 25:75, 2:98, 0:100, and 0:100 are obtained for (X, Y)=(S, F), (O, F), (S, Cl), (S, Br), (O, Cl), and (O, Br), respectively. The properties of the energy profiles after the TS cannot provide a rationalization of these results. Analysis of the energy flow in dynamics shows that the trajectories cross a dynamical bifurcation, and that the inability to follow the minimum energy path arises from long vibration periods of the X−C⋅⋅⋅Y bending mode. The partition of the available energy to the products into vibrational, rotational, and translational energies reveals that if the vibrational contribution is more than 80 %, non‐IRC behavior dominates, unless the relative fraction of the rotational and translational components is similar, in which case a richer dynamical mechanism is shown, with an IRC/non‐IRC ratio that correlates to this relative fraction.
Selective P4 Activation by a Highly Reduced Cobaltate: Synthesis of Dicobalt Tetraphosphido Complexes
Authors: Pelties Stefan , Maier Thomas , Herrmann Dirk , de Bruin Bas , Rebreyend Christophe , Gärtner Stefanie , Shenderovich Ilya G. , Wolf Robert 
Published: September 2016

AbstractAlthough the chemistry of transition metal polyphosphide anions has attracted significant attention, there are few reports of studies in which such species have been synthesized directly from white phosphorus. [K(OEt2)2{Co(BIAN)(cod)}] (1, BIAN=1,2‐bis(2,6‐diisopropylphenylimino)acenaphthene, cod=1,5‐cyclooctadiene), which is readily prepared by ligand exchange from [K(thf)x{Co(cod)2}], reacts with P4 to afford [{K(thf)}2{(BIAN)Co}2(μ‐η4:η4‐P4)] (2 a) in 61 % yield (isolated product). [{K(OEt2)}2{(BIAN)Co}2(μ‐η4:η4‐P4)] (2 b) and [K([18]crown‐6)(MeCN)]2[{(BIAN)Co}2(μ‐η4:η4‐P4)] (2 c) were obtained by recrystallizing 2 a from diethyl ether and acetonitrile (and using [18]crown‐6 in case of 2 c). Oxidation of 2 a with [Cp2Fe]BArF4 (one equivalent) and subsequent recrystallization of the product from different solvents gave [K(OEt2){(BIAN)Co}2(μ‐η4:η4‐P4)] (3 a) and [K(dme)4][{(BIAN)Co}2(μ‐η4:η4‐P4)] (3 b; dme=1,2‐dimethoxyethane). Neutral [{(BIAN)Co}2(μ‐η4:η4‐P4)] (4) was obtained in moderate yield by oxidizing 2 a with two equivalents of [Cp2Fe]BArF4. The new complexes were characterized by NMR, EPR (in the case of 3 a), and UV/Vis spectroscopy, and elemental analysis. The molecular structures revealed by X‐ray crystallography display planar cyclic or open‐chain P44− units sandwiched between {(BIAN)Co} fragments.
The Copper(II)‐Catalyzed Oxidation of Glutathione
Authors: Ngamchuea Kamonwad , Batchelor‐McAuley Christopher , Compton Richard G. 
Published: September 2016

AbstractThe kinetics and mechanisms of the copper(II)‐catalyzed GSH (glutathione) oxidation are examined in the light of its biological importance and in the use of blood and/or saliva samples for GSH monitoring. The rates of the free thiol consumption were measured spectrophotometrically by reaction with DTNB (5,5′‐dithiobis‐(2‐nitrobenzoic acid)), showing that GSH is not auto‐oxidized by oxygen in the absence of a catalyst. In the presence of Cu2+, reactions with two timescales were observed. The first step (short timescale) involves the fast formation of a copper–glutathione complex by the cysteine thiol. The second step (longer timescale) is the overall oxidation of GSH to GSSG (glutathione disulfide) catalyzed by copper(II). When the initial concentrations of GSH are at least threefold in excess of Cu2+, the rate law is deduced to be −d[thiol]/dt=k[copper–glutathione complex][O2]0.5[H2O2]−0.5. The 0.5th reaction order with respect to O2 reveals a pre‐equilibrium prior to the rate‐determining step of the GSSG formation. In contrast to [Cu2+] and [O2], the rate of the reactions decreases with increasing concentrations of GSH. This inverse relationship is proposed to be a result of the competing formation of an inactive form of the copper–glutathione complex (binding to glutamic and/or glycine moieties).
General, Simple, and Chemoselective Catalysts for the Isomerization of Allylic Alcohols: The Importance of the Halide Ligand
Authors: Erbing Elis , Vázquez‐Romero Ana , Bermejo Gómez Antonio , Platero‐Prats Ana E. , Carson Fabian , Zou Xiaodong , Tolstoy Päivi , Martín‐Matute Belén 
Published: September 2016

AbstractRemarkably simple IrIII catalysts enable the isomerization of primary and sec‐allylic alcohols under very mild reaction conditions. X‐ray absorption spectroscopy (XAS) and mass spectrometry (MS) studies indicate that the catalysts, with the general formula [Cp*IrIII], require a halide ligand for catalytic activity, but no additives or additional ligands are needed.
Motoneuron glutamatergic receptor expression following recovery from cervical spinal hemisection
Authors: Gransee Heather M. , Gonzalez Porras Maria A. , Zhan Wen‐Zhi , Sieck Gary C. , Mantilla Carlos B. 
Published: September 2016

ABSTRACTCervical spinal hemisection at C2 (SH) removes premotor drive to phrenic motoneurons located in segments C3–C5 in rats. Spontaneous recovery of ipsilateral diaphragm muscle activity is associated with increased phrenic motoneuron expression of glutamatergic N‐methyl‐D‐aspartate (NMDA) receptors and decreased expression of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐proprionic acid (AMPA) receptors. Glutamatergic receptor expression is regulated by tropomyosin‐related kinase receptor subtype B (TrkB) signaling in various neuronal systems, and increased TrkB receptor expression in phrenic motoneurons enhances recovery post‐SH. Accordingly, we hypothesize that recovery of ipsilateral diaphragm muscle activity post‐SH, whether spontaneous or enhanced by adenoassociated virus (AAV)‐mediated upregulation of TrkB receptor expression, is associated with increased expression of glutamatergic NMDA receptors in phrenic motoneurons. Adult male Sprague‐Dawley rats underwent diaphragm electromyography electrode implantation and SH surgery. Rats were injected intrapleurally with AAV expressing TrkB or GFP 3 weeks before SH. At 14 days post‐SH, the proportion of animals displaying recovery of ipsilateral diaphragm activity increased in AAV–TrkB‐treated (9/9) compared with untreated (3/5) or AAV–GFP‐treated (4/10; P < 0.027) animals. Phrenic motoneuron NMDA NR1 subunit mRNA expression was approximately fourfold greater in AAV–TrkB‐ vs. AAV–GFP‐treated SH animals (P < 0.004) and in animals displaying recovery vs. those not recovering (P < 0.005). Phrenic motoneuron AMPA glutamate receptor 2 (GluR2) subunit mRNA expression decreased after SH, and, albeit increased in animals displaying recovery vs. those not recovering, levels remained lower than control. We conclude that increased phrenic motoneuron expression of glutamatergic NMDA receptors is associated with spontaneous recovery after SH and enhanced recovery after AAV–TrkB treatment. J. Comp. Neurol. 525:1192–1205, 2017. © 2016 Wiley Periodicals, Inc.
Disclosing the High Activity of Ceramic Metallics in the Oxygen Evolution Reaction: Nickel Materials as a Case Study
Authors: Ledendecker Marc , Yang Xiaofei , Antonietti Markus , Shalom Menny 
Published: September 2016

AbstractHere, we elucidate the activity origin of ceramic nickel electrocatalysts in the oxygen evolution reaction (OER), ranging from nitrides, sulfides, and phosphides, as a case study that may be projected on almost any ceramic metallic. Our results show that regardless of the starting material, the formation of an active (oxy)hydroxide layer, acting as the real electrocatalyst during the OER, is unavoidable. Nevertheless, the in situ transformation into highly active (oxy)hydroxides leads to the formation of active catalysts for various applications.
Fractional‐order electronically controlled generalized filters
Authors: Tsirimokou Georgia , Psychalinos Costas , Elwakil Ahmed S. 
Published: September 2016

SummaryNovel topologies of fractional‐order generalized filters are introduced in this paper. These offer the following benefits: (1) realization of lowpass, highpass, bandpass, allpass, or bandstop filter functions by the same topology; (2) resistorless realizations; (3) electronic adjustment of their frequency characteristics as well as their order; and (4) employment of only grounded capacitors. All the above have been achieved using Operational Transconductance Amplifiers as active elements and appropriate multi‐feedback topologies. The behavior of the proposed designs is verified through simulation results using the Cadence IC design suite and the Design Kit provided by the Austrian Micro Systems 0.35‐µm complementary metal–oxide–semiconductor process. Copyright © 2016 John Wiley & Sons, Ltd.
Analysis and improvement of the Internet‐Draft IKEv3 protocol
Authors: Cheng Qingfeng , Lu Siqi , Ma Jianfeng 
Published: September 2016

SummaryInternet protocol (IP) is the kernel of the TCP/IP protocol family. Because IP is the only one that is shared by all high‐level protocols in TCP/IP. So the security of the IP is particularly important to the whole communication network. Fortunately, IPsec provides excellent protection for the kIP security. As a part of the IPsec, Internet Key Exchange (IKE) protocol can achieve security association negotiation, key generation, and identity authentication. The study of IKEv2, both in its application and security analysis, has been relatively mature. When the Internet Engineering Task Force published the Internet‐Draft IKEv3 protocol, there is not much attention and research on it. In this paper, we analyze the security and authentication of IKEv3 by formal verification and show that IKEv3 is susceptible to reflection attack and DoS attack. Then we propose a new variant of the IKEv3 protocol, which both resists reflection attack and mitigates the impact of the DoS attack.
Invasion in patchy landscapes is affected by dispersal mortality and mate‐finding failure
Authors: Walter Jonathan A. , Firebaugh Ariel L. , Tobin Patrick C. , Haynes Kyle J. 
Published: September 2016

AbstractRange expansions are a function of population growth and dispersal, and nascent populations often must overcome demographic Allee effects (positive density dependence at low population densities) driven by factors such as mate‐finding failure. Given the importance of individual movement to mate finding, links between landscape structure and movement may be critical to range expansion; however, landscape effects on other factors including mortality may be equally or more important. In one of the most comprehensive investigations of the interactions of these processes to date, we combined field experiments, simulation modeling, and analysis of empirical spread patterns to investigate how landscape structure affected the spread of the gypsy moth in Virginia and West Virginia. In experiments designed to assess how landscape attributes affect mate finding, we found adult males resisted leaving forest patches and the probability of locating a pheromone source declined more rapidly over distance in non‐forest matrix than in forest. We used these findings to develop individual‐based simulation models of gypsy moth population dynamics and spread in complex patch‐matrix landscapes. The models produced an Allee effect that strengthened with reductions in forested area, but owing more so to dispersal mortality than to effects on mate location. Predicted maximum rates of population spread grew with increases in forest area due to increasing success of long‐distance transport events. Evaluations of empirical data showed relationships between spread rates and landscape structure largely consistent with model predictions. We conclude rates of spread were largely driven by long‐distance dispersal events, the success of which was influenced primarily by dispersal mortality of larvae in unsuitable matrix, and that landscape effects on mate location played a secondary role. Though influences of landscape structure on mate location appear to be unimportant to the spread of the gypsy moth, we predict they would have stronger effects on more dispersive species.
Gemcitabine induced cardiomyopathy: a case of multiple hit cardiotoxicity
Authors: Mohebali Donya , Matos Jason , Chang James Ducksoon 
Published: September 2016

AbstractGemcitabine is a commonly used antineoplastic agent used to treat a variety of cancers with rarely reported cardiac side effects. We describe a case of a 67‐year‐old woman with follicular lymphoma who experienced a rarely reported side effect of gemcitabine: cardiomyopathy. This case highlights a multiple hit mechanism of myocyte damage that may occur following the use of multiple cardio‐toxic agents despite their administration in doses not associated with cardiotoxicity.
Versatile Electrochemical Platform for the Determination of Phenol‐like Compounds Based on Laccases from Different Origins
Authors: Borón Ignacio , Wirth Sonia , Battaglini Fernando 
Published: September 2016

AbstractSimple and fast methods for the monitoring of phenol‐like compounds are relevant in diverse fields ranging from waste management to neurosciences. Laccases are copper‐containing enzymes, which, depending on their origin, are able to oxidize different phenol compounds at different pH conditions. Through adequate laccase immobilization, disposable screen printed electrodes can be used as interphase to build amperometric phenol sensors. In this work three different laccases were studied for the determination of phenol‐like compounds, two of them are isoenzymes from Trametes trogii and the third one from Rhus vernicifera. Their immobilization on screen printed electrodes is presented for the construction of amperometric sensors. The electrode substrate is composed by graphite screen printed electrodes modified with carbon nanotubes and silica microspheres where, depending on the application, one of the three laccases is adsorbed. As each laccase shows an optimum working pH, they were conveniently selected to determine dopamine at physiological pH and catechol at acid pH. Determinations in the micromolar range were possible in both cases. Chronoamperometry shows to be an effective technique for their determinations, simpler than other electrochemical methods already presented in the literature.
Boron and Nitrogen Doped Graphene via Microwave Exfoliation for Simultaneous Electrochemical Detection of Ascorbic Acid, Dopamine and Uric Acid
Authors: Thearle Rozi Alice , Latiff Naziah Mohamad , Sofer Zdenek , Mazánek Vlastimil , Pumera Martin 
Published: September 2016

AbstractBoron and nitrogen doped graphenes show opposite effect on the electronic structure, one with electron withdrawing and another one with electron donating effects. It is of high importance to investigate the influence of B or N doping on biomarkers detection and compare it to non‐doped graphene. Here we show that B‐doped graphene shows significant enhancement in detection currents in the cyclic voltammetry of the above mentioned compounds.