bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel foraging by wintering Siberian CranesLeucogeranus leucogeranusat China’s Poyang Lake indicates broader changes in the ecosystem and raises new challenges for a critically endangered species
Authors: BURNHAM JAMES , BARZEN JEB , PIDGEON ANNA M. , SUN BAOTENG , WU JIANDONG , LIU GUANHUA , JIANG HONGXING 
Published: January 2017

SummaryFollowing an abnormal flood in 2010 at China’s Poyang Lake, we observed wintering Siberian CranesLeucogeranus leucogeranusswitch from foraging in the shallow-water wetlands they typically use to grassland habitats. These previously undocumented habitat selection patterns raised questions whether differences in crane behaviour such as foraging success existed between the two habitats and how those differences might affect this critically endangered species. Over two winters, we used the density of customary food items (tubers ofVallisneriaspp.) obtained from long-term monitoring efforts, Siberian Cranes flock behaviours, individual foraging success and estimated total flock foraging effort across both habitats. Novel foraging patterns by Siberian Cranes were associated with low densities ofVallisneriatubers across multiple sub-lakes within Poyang Lake National Nature Reserve (PLNR). Foraging success was higher in grasslands than in wetlands in winter 2010–2011, but higher in wetlands following a recovery ofVallisneriain 2011–2012. Subsequent to upland foraging during the winter of 2010–2011, we observed lower juvenile to adult ratio of Siberian Cranes at a fall migratory stopover location in north-eastern China despite indications of average environmental conditions in the nesting areas from 2010 to 2012. While grasslands adjacent to shallow-water habitats may be important refugia for wintering Siberian Cranes whenVallisneriais absent or inaccessible, and should be included in protected areas, multi-year dependence on grasslands for foraging could negatively impact population levels. Eliminating crab farming in protected areas and extending protection to shallow water areas sheltered from flooding by dykes could also help secure high quality foraging habitat under a variety of hydrological regimes. Novel foraging patterns by wintering Siberian Cranes represent a new challenge to the conservation efforts for this species that focus on shallow-water wetlands, and may be indicative of broader changes within Poyang’s ecosystem.
Programming maternal and child overweight and obesity in the context of undernutrition: current evidence and key considerations for low- and middle-income countries
Authors: Jaacks Lindsay M , Kavle Justine , Perry Abigail , Nyaku Albertha 
Published: January 2017

AbstractThe goals of the present targeted review on maternal and child overweight and obesity were to: (i) understand the current situation in low- and middle-income countries (LMIC) with regard to recent trends and context-specific risk factors; and (ii) building off this, identify entry points for leveraging existing undernutrition programmes to address overweight and obesity in LMIC. Trends reveal that overweight and obesity are a growing problem among women and children in LMIC; as in Ghana, Kenya, Niger, Sierra Leone, Tanzania and Zimbabwe, where the prevalence among urban women is approaching 50 %. Four promising entry points were identified: (i) the integration of overweight and obesity into national nutrition plans; (ii) food systems (integration of food and beverage marketing regulations into existing polices on the marketing of breast-milk substitutes and adoption of policies to promote healthy diets); (iii) education systems (integration of nutrition into school curricula with provision of high-quality foods through school feeding programmes); and (iv) health systems (counselling and social and behaviour change communication to improve maternal diet, appropriate gestational weight gain, and optimal infant and young child feeding practices). We conclude by presenting a step-by-step guide for programme officers and policy makers in LMIC with actionable objectives to address overweight and obesity.
Farm level implementation of soil conservation measures: farmers’ beliefs and intentions
Authors: Werner Magdalena , Wauters Erwin , Bijttebier Jo , Steinmann Horst-Henning , Ruysschaert Greet , Knierim Andrea 
Published: January 2017

AbstractUnderstanding motivating factors for taking soil conservation measures is seen as key to improving on-farm implementation. However, to date only few on-farm conservation measures have been investigated. The objective of this paper is to investigate the influence of farmers’ subjective beliefs on their intention to apply and actual implementation of cover cropping, with the region of Brandenburg (Germany) as a case. An additional objective was to investigate how these insights can contribute to increase farm level implementation of soil conservation measures. Theory of planned behavior provides an approach to understand human behavior by analyzing farmers’ subjective beliefs. Our results, based on a survey of 96 farmers, show that attitudes (ATTs) and perceived difficulty significantly explain variations in intention to apply cover cropping, with ATTs being generally very positive. We discuss that, in this case, the most effective way to increase on-farm implementation is to decrease the farmers’ perception of difficulty. This can be achieved by providing information to farmers on how to overcome barriers to implementation of conservation measures. In-depth insights into belief structures reveal what kind of information is most useful in the case of cover cropping.
Common mental health problems in rural-to-urban migrant workers in Shenzhen, China: prevalence and risk factors
Authors: Zhong B. L. , Liu T. B. , Chan S. S. M. , Jin D. , Hu C. Y. , Dai J. , Chiu H. F. K. 
Published: January 2017

Aims.Rural-to-urban migrant workers are a large marginalised population in urban China. Prevalence estimates of common mental health problems (CMHPs) in previous studies varied widely and very few studies have investigated migration-related factors of CMHPs in migrant workers. The objective of this study was to determine the prevalence and risk factors of CMHPs among Chinese migrant workers.Methods.A random sample of 3031 migrant workers of ten manufacturing factories in Shenzhen, China, completed a standardised questionnaire containing socio-demographic and migration-related variables and the Chinese 12-item General Health Questionnaire (GHQ-12). A GHQ-12 score of three or higher was used to denote the presence of CMHPs.Results.The prevalence of CMHPs was 34.4% in Chinese migrant workers. In multiple logistic regression, risk factors for CMHPs included being 16–25 years old (odd ratio [OR] 1.65, 95% confidence interval [CI] 1.28, 2.12), being 26–35 years old (OR 1.36, 95% CI: 1.05, 1.75), low monthly income (OR 1.42, 95% CI 1.04, 1.92), poor living condition (OR: 1.76, 95% CI: 1.22, 2.54), physical illness in the past 2 weeks (OR 1.72, 95% CI 1.43, 2.05), having worked in many cities (OR 1.34, 95% CI 1.03, 1.74), infrequently visiting hometown (OR 1.56, 95% CI 1.22, 1.99), poor Mandarin proficiency (OR 1.51, 95%CI 1.13, 2.01), a low level of perceived benefits of migration (OR 1.33, 95% CI 1.14, 1.55) and working more than 8 h/day (OR 1.39, 95% CI 1.14, 1.70).Conclusions.CMHPs are very prevalent among Chinese migrant workers. Given the large number of Chinese migrant workers, there is an urgent need to address the mental health burden of China's migrant worker population.
The Ecology of Social Learning in Animals and its Link with Intelligence
Authors: van Schaik Carel , Graber Sereina , Schuppli Caroline , Burkart Judith 
Published: January 2017

AbstractClassical ethology and behavioral ecology did not pay much attention to learning. However, studies of social learning in nature reviewed here reveal the near-ubiquity of reliance on social information for skill acquisition by developing birds and mammals. This conclusion strengthens the plausibility of the cultural intelligence hypothesis for the evolution of intelligence, which assumes that selection on social learning abilities automatically improves individual learning ability. Thus, intelligent species will generally be cultural species. Direct tests of the cultural intelligence hypothesis require good estimates of the amount and kind of social learning taking place in nature in a broad variety of species. These estimates are lacking so far. Here, we start the process of developing a functional classification of social learning, in the form of the social learning spectrum, which should help to predict the mechanisms of social learning involved. Once validated, the categories can be used to estimate the cognitive demands of social learning in the wild.
Cognition and Culture in Evolutionary Context
Authors: Colmenares Fernando , Hernández-Lloreda María Victoria 
Published: January 2017

AbstractIn humans and other animals, the individuals’ ability to adapt efficiently and effectively to the niches they have actively contributed to construct relies heavily on an evolved psychology which has been shaped by biological, social, and cultural processes over evolutionary time. As expected, although many of the behavioral and cognitive components of this evolved psychology are widely shared across species, many others are species-unique. Although many animal species are known to acquire group-specific traditions (or cultures) via social learning, human culture is unique in terms of its contents and characteristics (observable and unobservable products, cumulative effects, norm conformity, and norm enforcement) and of its cognitive underpinnings (imitation, instructed teaching, and language). Here we provide a brief overview of some of the issues that are currently tackled in the field. We also highlight some of the strengths of a biological, comparative, non-anthropocentric and evolutionarily grounded approach to the study of culture. The main contributions of this approach to the science of culture are its emphasis (a) on the integration of information on mechanisms, function, and evolution, and on mechanistic factors located at different levels of the biological hierarchy, and (b) on the search for general principles that account for commonalities and differences between species, both in the cultural products and in the processes of innovation, dissemination, and accumulation involved that operate during developmental and evolutionary timespans.
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
Authors: Taylor Renea A. , Fraser Michael , Livingstone Julie , Espiritu Shadrielle Melijah G. , Thorne Heather , Huang Vincent , Lo Winnie , Shiah Yu-Jia , Yamaguchi Takafumi N. , Sliwinski Ania , Horsburgh Sheri , Meng Alice , Heisler Lawrence E. , Yu Nancy , Yousif Fouad , Papargiris Melissa , Lawrence Mitchell G. , Timms Lee , Murphy Declan G. , Frydenberg Mark , Hopkins Julia F. , Bolton Damien , Clouston David , McPherson John D. , van der Kwast Theodorus , Boutros Paul C. , Risbridger Gail P. , Bristow Robert G. 
Published: January 2017

AbstractGermline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes and methylomes of localized PCa from 14 carriers of deleterious germline BRCA2 mutations (BRCA2-mutant PCa). We show that BRCA2-mutant PCa harbour increased genomic instability and a mutational profile that more closely resembles metastastic than localized disease. BRCA2-mutant PCa shows genomic and epigenomic dysregulation of the MED12L/MED12 axis, which is frequently dysregulated in metastatic castration-resistant prostate cancer (mCRPC). This dysregulation is enriched in BRCA2-mutant PCa harbouring intraductal carcinoma (IDC). Microdissection and sequencing of IDC and juxtaposed adjacent non-IDC invasive carcinoma in 10 patients demonstrates a common ancestor to both histopathologies. Overall we show that localized castration-sensitive BRCA2-mutant tumours are uniquely aggressive, due to de novo aberration in genes usually associated with metastatic disease, justifying aggressive initial treatment.
Quantum-chemical insights from deep tensor neural networks
Authors: Schütt Kristof T. , Arbabzadah Farhad , Chmiela Stefan , Müller Klaus R. , Tkatchenko Alexandre 
Published: January 2017

AbstractLearning from data has led to paradigm shifts in a multitude of disciplines, including web, text and image search, speech recognition, as well as bioinformatics. Can machine learning enable similar breakthroughs in understanding quantum many-body systems? Here we develop an efficient deep learning approach that enables spatially and chemically resolved insights into quantum-mechanical observables of molecular systems. We unify concepts from many-body Hamiltonians with purpose-designed deep tensor neural networks, which leads to size-extensive and uniformly accurate (1 kcal mol−1) predictions in compositional and configurational chemical space for molecules of intermediate size. As an example of chemical relevance, the model reveals a classification of aromatic rings with respect to their stability. Further applications of our model for predicting atomic energies and local chemical potentials in molecules, reliable isomer energies, and molecules with peculiar electronic structure demonstrate the potential of machine learning for revealing insights into complex quantum-chemical systems.
Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
Authors: Bothmer Anne , Phadke Tanushree , Barrera Luis A. , Margulies Carrie M , Lee Christina S. , Buquicchio Frank , Moss Sean , Abdulkerim Hayat S. , Selleck William , Jayaram Hariharan , Myer Vic E. , Cotta-Ramusino Cecilia 
Published: January 2017

AbstractThe CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these lesions and the repair pathways engaged is critical to realizing the full potential of this technology. Here we characterize the different lesions arising from each Cas9 variant and the resulting repair pathway engagement. We demonstrate that the presence and polarity of the overhang structure is a critical determinant of double-strand break repair pathway choice. Similarly, single nicks deriving from different Cas9 variants differentially activate repair: D10A but not N863A-induced nicks are repaired by homologous recombination. Finally, we demonstrate that homologous recombination is required for repairing lesions using double-stranded, but not single-stranded DNA as a template. This detailed characterization of repair pathway choice in response to CRISPR–Cas9 enables a more deterministic approach for designing research and therapeutic genome engineering strategies.
Ultrafast evolution and transient phases of a prototype out-of-equilibrium Mott–Hubbard material
Authors: Lantz G. , Mansart B. , Grieger D. , Boschetto D. , Nilforoushan N. , Papalazarou E. , Moisan N. , Perfetti L. , Jacques V. L. R. , Le Bolloc'h D. , Laulhé C. , Ravy S. , Rueff J-P , Glover T. E. , Hertlein M. P. , Hussain Z. , Song S. , Chollet M. , Fabrizio M. , Marsi M. 
Published: January 2017

AbstractThe study of photoexcited strongly correlated materials is attracting growing interest since their rich phase diagram often translates into an equally rich out-of-equilibrium behaviour. With femtosecond optical pulses, electronic and lattice degrees of freedom can be transiently decoupled, giving the opportunity of stabilizing new states inaccessible by quasi-adiabatic pathways. Here we show that the prototype Mott–Hubbard material V2O3 presents a transient non-thermal phase developing immediately after ultrafast photoexcitation and lasting few picoseconds. For both the insulating and the metallic phase, the formation of the transient configuration is triggered by the excitation of electrons into the bonding a1g orbital, and is then stabilized by a lattice distortion characterized by a hardening of the A1g coherent phonon, in stark contrast with the softening observed upon heating. Our results show the importance of selective electron–lattice interplay for the ultrafast control of material parameters, and are relevant for the optical manipulation of strongly correlated systems.
Coherent ultra-violet to near-infrared generation in silica ridge waveguides
Authors: Yoon Oh Dong , Yang Ki Youl , Fredrick Connor , Ycas Gabriel , Diddams Scott A. , Vahala Kerry J. 
Published: January 2017

AbstractShort duration, intense pulses of light can experience dramatic spectral broadening when propagating through lengths of optical fibre. This continuum generation process is caused by a combination of nonlinear optical effects including the formation of dispersive waves. Optical analogues of Cherenkov radiation, these waves allow a pulse to radiate power into a distant spectral region. In this work, efficient and coherent dispersive wave generation of visible to ultraviolet light is demonstrated in silica waveguides on a silicon chip. Unlike fibre broadeners, the arrays provide a wide range of emission wavelength choices on a single, compact chip. This new capability is used to simplify offset frequency measurements of a mode-locked frequency comb. The arrays can also enable mode-locked lasers to attain unprecedented tunable spectral reach for spectroscopy, bioimaging, tomography and metrology.
Multiple Dirac cones at the surface of the topological metal LaBi
Authors: Nayak Jayita , Wu Shu-Chun , Kumar Nitesh , Shekhar Chandra , Singh Sanjay , Fink Jörg , Rienks Emile E. D. , Fecher Gerhard H. , Parkin Stuart S. P. , Yan Binghai , Felser Claudia 
Published: January 2017

AbstractThe rare-earth monopnictide LaBi exhibits exotic magneto-transport properties, including an extremely large and anisotropic magnetoresistance. Experimental evidence for topological surface states is still missing although band inversions have been postulated to induce a topological phase in LaBi. In this work, we have revealed the existence of surface states of LaBi through the observation of three Dirac cones: two coexist at the corners and one appears at the centre of the Brillouin zone, by employing angle-resolved photoemission spectroscopy in conjunction with ab initio calculations. The odd number of surface Dirac cones is a direct consequence of the odd number of band inversions in the bulk band structure, thereby proving that LaBi is a topological, compensated semimetal, which is equivalent to a time-reversal invariant topological insulator. Our findings provide insight into the topological surface states of LaBi’s semi-metallicity and related magneto-transport properties.
Adsorbate-induced lattice deformation in IRMOF-74 series
Authors: Jawahery Sudi , Simon Cory M. , Braun Efrem , Witman Matthew , Tiana Davide , Vlaisavljevich Bess , Smit Berend 
Published: January 2017

AbstractIRMOF-74 analogues are among the most widely studied metal-organic frameworks (MOFs) for adsorption applications because of their one-dimensional channels and high metal density. Most studies involving the IRMOF-74 series assume that the crystal lattice is rigid. This assumption guides the interpretation of experimental data, as changes in the crystal symmetry have so far been ignored as a possibility in the literature. Here, we report a deformation pattern, induced by the adsorption of argon, for IRMOF-74-V. This work has two main implications. First, we use molecular simulations to demonstrate that the IRMOF-74 series undergoes a deformation that is similar to the mechanism behind breathing MOFs, but is unique because the deformation pattern extends beyond a single unit cell of the original structure. Second, we provide an alternative interpretation of experimental small-angle X-ray scattering profiles of these systems, which changes how we view the fundamentals of adsorption in this MOF series.
Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
Authors: Consalvi Silvia , Brancaccio Arianna , Dall’Agnese Alessandra , Puri Pier Lorenzo , Palacios Daniela 
Published: January 2017

AbstractPolycomb proteins are critical chromatin modifiers that regulate stem cell differentiation via transcriptional repression. In skeletal muscle progenitors Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), contributes to maintain the chromatin of muscle genes in a repressive conformation, whereas its down-regulation allows the progression through the myogenic programme. Here, we show that p38α kinase promotes EZH2 degradation in differentiating muscle cells through phosphorylation of threonine 372. Biochemical and genetic evidence demonstrates that the MYOD-induced E3 ubiquitin ligase Praja1 (PJA1) is involved in regulating EZH2 levels upon p38α activation. EZH2 premature degradation in proliferating myoblasts is prevented by low levels of PJA1, its cytoplasmic localization and the lower activity towards unphosphorylated EZH2. Our results indicate that signal-dependent degradation of EZH2 is a prerequisite for satellite cells differentiation and identify PJA1 as a new player in the epigenetic control of muscle gene expression.
Regional adaptation defines sensitivity to future ocean acidification
Authors: Calosi Piero , Melatunan Sedercor , Turner Lucy M. , Artioli Yuri , Davidson Robert L. , Byrne Jonathan J. , Viant Mark R. , Widdicombe Stephen , Rundle Simon D. 
Published: January 2017

AbstractPhysiological responses to temperature are known to be a major determinant of species distributions and can dictate the sensitivity of populations to global warming. In contrast, little is known about how other major global change drivers, such as ocean acidification (OA), will shape species distributions in the future. Here, by integrating population genetics with experimental data for growth and mineralization, physiology and metabolomics, we demonstrate that the sensitivity of populations of the gastropod Littorina littorea to future OA is shaped by regional adaptation. Individuals from populations towards the edges of the natural latitudinal range in the Northeast Atlantic exhibit greater shell dissolution and the inability to upregulate their metabolism when exposed to low pH, thus appearing most sensitive to low seawater pH. Our results suggest that future levels of OA could mediate temperature-driven shifts in species distributions, thereby influencing future biogeography and the functioning of marine ecosystems.
Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
Authors: Wei Yao , Wang Dong , Jin Fangfang , Bian Zhen , Li Limin , Liang Hongwei , Li Mingzhen , Shi Lei , Pan Chaoyun , Zhu Dihan , Chen Xi , Hu Gang , Liu Yuan , Zhang Chen-Yu , Zen Ke 
Published: January 2017

AbstractTumour cells secrete exosomes that are involved in the remodelling of the tumour–stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), which is upregulated and phosphorylated in tumours. During exosome secretion, phosphorylated PKM2 serves as a protein kinase to phosphorylate synaptosome-associated protein 23 (SNAP-23), which in turn enables the formation of the SNARE complex to allow exosomes release. Direct phosphorylation assay and mass spectrometry confirm that PKM2 phosphorylates SNAP-23 at Ser95. Ectopic expression of non-phosphorylated SNAP-23 mutant (Ser95→Ala95) significantly reduces PKM2-mediated exosomes release whereas expression of selective phosphomimetic SNAP-23 mutants (Ser95→Glu95 but not Ser20→Glu20) rescues the impaired exosomes release induced by PKM2 knockdown. Our findings reveal a non-metabolic function of PKM2, an enzyme associated with tumour cell reliance on aerobic glycolysis, in promoting tumour cell exosome release.