bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Results of NURE-Combo: A Phase II Study of Neoadjuvant Nivolumab and Nab-Paclitaxel, Followed by Postsurgical Adjuvant Nivolumab, for Muscle-Invasive Bladder Cancer
Authors: Mercinelli Chiara , Moschini Marco , Cigliola Antonio , Mattorre Benedetta , Tateo Valentina , Basile Giuseppe , Cogrossi Laura L. , Maiorano Brigida A. , Patanè Damiano A. , Raggi Daniele , Pastorino Giovanni L. , Re Chiara , Colecchia Maurizio , Lucianò Roberta , Colombo Renzo , Brembilla Giorgio , De Cobelli Francesco , Briganti Alberto , Pavlick Dean C. , Ross Jeffrey S. , Montorsi Francesco , Bellone Matteo , Necchi Andrea 
Published: September 2024

PURPOSE
To evaluate the activity and safety of nivolumab with nab-paclitaxel as neoadjuvant therapy, followed by radical cystectomy (RC) and postsurgical adjuvant nivolumab in patients with muscle-invasive bladder cancer (MIBC).

PATIENTS AND METHODS

Eligible patients had an Eastern Cooperative Oncology Group performance status of ≤1 and a T2-4aN0-1M0 stage with >50% urothelial carcinoma histology and were ineligible for or refused cisplatin-based chemotherapy. Patients received four cycles of nivolumab 360 mg once every 3 weeks + nab-paclitaxel 125 mg/m
2
once on days 1 and 8, every 3 weeks, followed by RC, and then adjuvant nivolumab 360 mg once every 3 weeks × 13 cycles. The primary end point was the pathologic complete response (CR) rate (ypT0N0). Secondary end points were major pathologic response (ypT≤1N0), safety, event-free survival (EFS), and overall survival.

RESULTS
Thirty-one patients were enrolled from December 2021 to June 2023; 19 (61.3%) had a cT2 stage, two (6.5%) had N1 stage, and 16 (51.6%) had a variant histology. Five patients (16.1%) received less than four full courses of neoadjuvant treatment because of treatment-related adverse events (TRAEs). Grade 3/4 TRAEs occurred in eight patients (25.8%). Twenty-eight patients underwent RC, and three refused RC after evidence of clinical CR and received a redo transurethral resection of the bladder tumor (reTURBT). The trial met its primary end point: 10 patients (32.3%; 95% CI, 16.7 to 51.4) achieved an ypT0N0 response. By including those who underwent reTURBT, 22 (70.9%; 95% CI, 55 to 87) achieved an ypT≤1N0-x response. After a median follow-up of 12 months (range, 5-22), two patients had a disease relapse after surgery. The 12-month EFS was 89.8% (95% CI, 79.5 to 100).

CONCLUSION
To our knowledge, the first results from NURE-Combo trial suggest that this combination could expand the therapeutic opportunities of immune-chemotherapy in patients with MIBC.
Fission yeast Duc1 links to ER–PM contact sites and influences PM lipid composition and cytokinetic ring anchoring
Authors: Willet Alaina H. , Park Joshua S. , Snider Chloe E. , Huang Jingdian Jamie , Chen Jun-Song , Gould Kathleen L. 
Published: September 2024

ABSTRACT
Cytokinesis is the final stage of the cell cycle that results in the physical separation of daughter cells. To accomplish cytokinesis, many organisms build an actin- and myosin-based cytokinetic ring (CR) that is anchored to the plasma membrane (PM). Defects in CR–PM anchoring can arise when the PM lipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] is depleted. In Schizosaccharomyces pombe, reduced PM PI(4,5)P2 results in a CR that cannot maintain a medial position and slides toward one cell end, resulting in two differently sized daughter cells. S. pombe PM PI(4,5)P2 is synthesized by the phosphatidylinositol 4-phosphate 5-kinase (PI5-kinase) Its3, but what regulates this enzyme to maintain appropriate PM PI(4,5)P2 levels in S. pombe is not known. To identify Its3 regulators, we used proximity-based biotinylation, and the uncharacterized protein Duc1 was specifically detected. We discovered that Duc1 decorates the PM except at the cell division site and that its unique localization pattern is dictated by binding to the endoplasmic reticulum (ER)–PM contact site proteins Scs2 and Scs22. Our evidence suggests that Duc1 also binds PI(4,5)P2 and helps enrich Its3 at the lateral PM, thereby promoting PM PI(4,5)P2 synthesis and robust CR–PM anchoring.
Odor exposure during imprinting periods increases odorant-specific sensitivity and receptor gene expression in coho salmon (Oncorhynchus kisutch)
Authors: Dittman Andrew H. , May Darran , Johnson Marc A. , Baldwin David H. , Scholz Nathaniel L. 
Published: September 2024

ABSTRACT
Pacific salmon are well known for their homing migrations; juvenile salmon learn odors associated with their natal streams prior to seaward migration, and then use these retained odor memories to guide them back from oceanic feeding grounds to their river of origin to spawn several years later. This memory formation, termed olfactory imprinting, involves (at least in part) sensitization of the peripheral olfactory epithelium to specific odorants. We hypothesized that this change in peripheral sensitivity is due to exposure-dependent increases in the expression of odorant receptor (OR) proteins that are activated by specific odorants experienced during imprinting. To test this hypothesis, we exposed juvenile coho salmon, Oncorhynchus kisutch, to the basic amino acid odorant l-arginine during the parr–smolt transformation (PST), when imprinting occurs, and assessed sensitivity of the olfactory epithelium to this and other odorants. We then identified the coho salmon ortholog of a basic amino acid odorant receptor (BAAR) and determined the mRNA expression levels of this receptor and other transcripts representing different classes of OR families. Exposure to l-arginine during the PST resulted in increased sensitivity to that odorant and a specific increase in BAAR mRNA expression in the olfactory epithelium relative to other ORs. These results suggest that specific increases in ORs activated during imprinting may be an important component of home stream memory formation and this phenomenon may ultimately be useful as a marker of successful imprinting to assess management strategies and hatchery practices that may influence straying in salmon.
Pride or Guilt? Impacts of Consumers’ Socially Influenced Recycling Behaviors on Closed-Loop Supply Chains
Authors: Huang Wenjie , Nguyen Jason , Tseng Chung-Li , Chen Wenlin , Kirshner Samuel N. 
Published: September 2024

Problem definition: Social influenced emotions of pride and guilt have been identified by the environmental psychology (EP) literature as crucial drivers impacting recycling behavior, but they have mostly been overlooked in operations management (OM) research. In contrast, EP studies often ignore firms’ operational decisions. We analyze the impacts of both social influence and firms’ operational decisions to provide a comprehensive understanding of consumers’ recycling behaviors, which is essential for realizing remanufacturing’s full potential. Methodology/results: We consider a closed-loop supply chain consisting of a manufacturer selling a single product to a consumer community. Consumers’ recycling behavior depends on both the recycling reward offered by the manufacturer, as well as intrinsic and socially influenced pride (guilt) from recycling (not recycling). We develop an evolutionary game to model consumers’ recycling behavior and characterize the resulting equilibrium recycling rate, which is then integrated into the manufacturer’s decision problem. We characterize the manufacturer’s optimal strategy and the equilibrium recycling rate in four distinct regions defined by both the product’s overall difficulty of remanufacturing and the underlying strengths of consumers’ socially influenced pride and guilt. We show that in settings where the product has a moderately high difficulty of remanufacturing and consumers have stronger socially influenced pride than guilt, the manufacturer optimally induces an interior recycling rate. In such scenarios, there exist win-win pathways in using social influence–based interventions to increase both the manufacturer’s profit and the recycling rate. However, misalignment may occur when consumers substantially care for the product’s recyclability. Managerial implications: This study bridges sustainable OM and EP literature by analyzing how consumers’ socially influenced emotions of pride and guilt affect a manufacturer’s optimal decisions, profits, and the resulting recycling rate. We provide important insights for designing effective and efficient social influence–based interventions to improve recycling rates. Funding: W. Chen was supported by the National Natural Science Foundation of China [Grant 71902017], and C.-L. Tseng was supported by the University of New South Wales UNOVA Knowledge Hub. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2023.0721 .
Automated Drift Compensation System for Electrical Conductivity and pH Probes in Hydroponic Systems
Authors: Cho Woo-Jae , Kim Dong-Wook , Kim Hak-Jin , Gang Minseok , Jung Daehyun , Yang Seung Hwan , Park Soo Hyun 
Published: September 2024

HighlightsUsed one- and two-point normalization to compensate for drifts in EC and pH probes in hydroponic systems.Developed automated sensor drift compensation systems for hydroponic systems.Evaluated the compensation systems for open- and closed-hydroponics.Application of the normalization methods increased the accuracy of the EC and pH measurements.Abstract. In hydroponic systems, the nutrient solutions are dispensed based on pH and electrical conductivity (EC) to ensure that the nutrient components in the solution are optimal for crop growth. However, the pH and EC probes may exhibit signal drifts when immersed in the solution for a considerable period, which deteriorate the measurement accuracy and the nutrient and water use efficiency. Notably, the existing hydroponic systems require manual calibration of the pH and EC probes and do not provide any information regarding their accuracy. Consequently, faults in the probes are challenging to detect. In this study, two types of automated drift compensation systems for EC and pH probes, based on one- and two-point normalization, were developed to accurately monitor changes in the pH and EC values in hydroponic solutions and enhance sensor management. The proposed framework can provide information regarding the drifts of the pH and EC probes through automated normalization solution measurements. The effectiveness of the developed system in scenarios involving plant growth with open and closed hydroponics was evaluated through comparison with a standard method involving sampling and laboratory analysis. The results indicated that the one-point normalization strategy had a simple structure and was effective in compensating drifted offsets of sensors. A two-point normalization strategy could effectively predict the sensor drifts as well as variations in the sensitivities, which could be used in the compensation processes. Application of the one-point normalization-based system increased the accuracy of the EC and pH measurements, with root mean square errors decreasing from 50 to 28.5 µS·cm-1 and 0.43 to 0.17 pH in the open hydroponic systems and from 68.7 to 38.3 µS·cm-1 and 0.15 to 0.11 pH in the closed systems, respectively. The two-point normalization-based system decreased the RMSEs from 44.6 to 33.4 µS·cm-1 and 0.55 to 0.20 pH for the EC and pH measurements, respectively. In addition, the decreased slope and coefficient of determination in the linear regression according to the system application proved the system can compensate for the drifts of the EC and pH probes. The proposed system provided accurate EC and pH measurements and sensor status information, promoting more efficient nutrient use and sensor maintenance. Keywords: Automation, Compensation, Drift, EC, Hydroponics, pH.
112  Gbps CMOS-compatible waveguide germanium photodetector for the 2  μm wavelength band with a 3.64  A/W response
Authors: Zhu Yupeng , Liu Zhi , Liu Zhipeng , Hu Yiling , Huang Qinxing , Yang Yazhou , Liu Xiangquan , Men Tao , Zhang Guangze , Zheng Jun , Zuo Yuhua , Cheng Buwen 
Published: September 2024

The 2 μm wavelength band emerges as a promising candidate for the next communication window to enhance the transmission capacity of data. A high-responsivity and high-speed photodetector operating at 2 μm is crucial for the 2-μm-wavelength-band communication system. Here, we present an on-chip waveguide-coupled germanium photodetector with remarkably high responsivity and data-receiving rate, employing subbandgap light absorption and avalanche multiplication. The device is designed with an ingenious and simple asymmetric lateral p-i-n junction structure and fabricated through a standard CMOS process by a commercial factory. It has a responsivity of 3.64 A/W and a maximum bandwidth of 50 GHz at 2 μm wavelength. For the first time, to the best of our knowledge, an optical receiving rate of up to 112 Gbps is demonstrated at 2 μm, verifying its feasibility in a high-speed 2-μm-band communication system. To the best of our knowledge, the proposed device stands out as the fastest photodiode with the highest responsivity among all group III-V and group IV photodetectors working in the 2 μm wavelength band.
Monolithic dispersion engineered mid-infrared quantum cascade laser frequency comb
Authors: Wu Dapeng , Ma Yu , Sun Yongqiang , Huang Ruixin , Zhang Jinchuan , Liu Shuman , Zhuo Ning , Zhai Shenqiang , Cheng Fengmin , Liu Fengqi , Lu Quanyong 
Published: September 2024

The high-power quantum cascade laser (QCL) frequency comb capable of room temperature operation is of great interest to high-precision measurement and low-noise molecular spectroscopy. While a significant amount of research is devoted to the longwave spectral range, shortwave 3–5 μm QCL combs are still relatively underdeveloped due to the excessive material dispersion. In this work, we propose a monolithic integrated multimode waveguide scheme for effective dispersion engineering and high-power-efficiency operation. Over watt-level output power at room temperature with a wall plug efficiency of 7% and robust dispersion reduction is achieved from a quantum cascade laser frequency comb at a wavelength approximately 4.6  μm. Narrow beatnote linewidth less than 1 kHz and clear dual-comb multiheterodyne comb lines manifest the coherent phase relation among the comb modes which is crucial to fast molecular spectroscopy. This monolithic dispersion engineered waveguide design is also compatible to an efficient active–passive optical coupling scheme and would open up a new research playground for ring comb and on-chip dual-comb spectroscopy.
Trans-spectral transfer of spatio-temporal optical Ferris wheel with nonlinear wave mixing
Authors: Wang Sandan , Yuan Jinpeng , Wang Lirong , Xiao Liantuan , Jia Suotang 
Published: September 2024

The trans-spectral manipulation of spatio-temporal structured light, characterized by dynamic inhomogeneous trajectories and a unique nature in the space–time domain, opens myriad possibilities for high-dimensional optical communication in the ultraviolet band. Here, we experimentally demonstrate the high-performance transfer of the spatio-temporal optical Ferris wheel beam from near-infrared to blue–violet wavelengths. Owing to the energy conservation and momentum conservation mechanism, the 420 nm output signal beam accurately retains the spatio-temporal characteristics of the 776 nm input probe optical Ferris wheel beam, facilitated by the 780 nm Gaussian pump beam. The identical multi-petal intensity profiles confirm the successful transfer of spatial characteristics from the input probe to the output signal beams. The fully synchronized rotation velocities and directions of the probe and signal beams demonstrate the precise transfer of temporal characteristics, achieving approximately 98% conversion accuracy. This work enables efficient information transfer across different wavelength bands and offers a promising approach for achieving high-dimensional quantum communication.
Susceptibility and infectiousness of SARS-CoV-2 in children versus adults, by variant (wild-type, alpha, delta): A systematic review and meta-analysis of household contact studies
Authors: Uthman Olalekan A. , Lyngse Frederik Plesner , Anjorin Seun , Hauer Barbara , Hakki Seran , Martinez Diego A. , Ge Yang , Jonnerby Jakob , Julin Cathinka Halle , Lin Gary , Lalvani Ajit , Loss Julika , Madon Kieran J. , Martinez Leonardo , Næss Lisbeth Meyer , Page Kathleen R. , Prieto Diana , Robertson Anna Hayman , Shen Ye , Wurm Juliane , Buchholz Udo 
Published: September 2024

Importance
Understanding the susceptibility and infectiousness of children and adolescents in comparison to adults is important to appreciate their role in the COVID-19 pandemic.

Objective
To determine SARS-CoV-2 susceptibility and infectiousness of children and adolescents with adults as comparator for three variants (wild-type, alpha, delta) in the household setting. We aimed to identify the effects independent of vaccination or prior infection.

Data sources
We searched EMBASE, PubMed and medRxiv up to January 2022.

Study selection
Two reviewers independently identified studies providing secondary household attack rates (SAR) for SARS-CoV-2 infection in children (0–9 years), adolescents (10–19 years) or both compared with adults (20 years and older).

Data extraction and synthesis
Two reviewers independently extracted data, assessed risk of bias and performed a random-effects meta-analysis model.

Main outcomes and measures
Odds ratio (OR) for SARS-CoV-2 infection comparing children and adolescents with adults stratified by wild-type (ancestral type), alpha, and delta variant, respectively. Susceptibility was defined as the secondary attack rate (SAR) among susceptible household contacts irrespective of the age of the index case. Infectiousness was defined as the SAR irrespective of the age of household contacts when children/adolescents/adults were the index case.

Results
Susceptibility analysis: We included 27 studies (308,681 contacts), for delta only one (large) study was available. Compared to adults, children and adolescents were less susceptible to the wild-type and delta, but equally susceptible to alpha. Infectiousness analysis: We included 21 studies (201,199 index cases). Compared to adults, children and adolescents were less infectious when infected with the wild-type and delta. Alpha -related infectiousness remained unclear, 0–9 year old children were at least as infectious as adults. Overall SAR among household contacts varied between the variants.

Conclusions and relevance
When considering the potential role of children and adolescents, variant-specific susceptibility, infectiousness, age group and overall transmissibility need to be assessed.
Geographical variation and predictors of missing essential newborn care items during the immediate postpartum period in Ethiopia: Spatial and multilevel count analyses
Authors: Hailegebireal Aklilu Habte , Kitila Aiggan Tamene 
Published: September 2024

Background
Essential Newborn care (ENC) is a High-quality universal newborn health care devised by the World Health Organization for the provision of prompt interventions rendered to newborns during the postpartum period. Even though conducting comprehensive studies could provide a data-driven approach to tackling barriers to service adoption, there was a dearth of studies in Ethiopia that assess the geographical variation and predictors of missing ENC. Hence, this study aimed to identify geographical, individual, and community-level predictors of missing ENC messages at the national level.

Methods
This study used the 2016 Ethiopian Demographic and Health Survey, by using a weighted sample of 7,590 women who gave birth within two years prior to the survey. The spatial analysis was carried out using Arc-GIS version 10.7 and SaTScan version 9.6 statistical software. Spatial autocorrelation (Moran’s I) was checked to figure out the non-randomness of the spatial variation of missing ENC in Ethiopia. Six items of care used to construct a composite index.0of ENC uptake were cord examination, temperature measurement, counselling on danger signs, counselling on breastfeeding, observation of breastfeeding, and measurement of birth weight. To assess the presence of significant differences in the mean number of ENC items across covariates, independent t-tests and one-way ANOVA were performed. Finally, a multilevel multivariable mixed-effect negative binomial regression was done by using STATA version 16. The adjusted incidence rate ratio (aIRR) with its corresponding 95% CI was used as a measure of association and variables with a p-value<0.05 were identified as significant predictors of ENC.

Results
The overall prevalence of missing ENC was 4,675 (61.6%) (95% CI: 60.5, 62.7) with a significant spatial variation across regions. The majority of Somali, Afar, south Amhara, and SNNPR regions had statistically significant hotspots for missing ENC. The mean (±SD) number of ENC items received was 1.23(±1.74) with a variance of 3.02 indicating over-dispersion. Living in the poorest wealth quintile (aIRR = 0.67, 95%CI: 0.51, 0.87), lack of Antenatal care (aIRR = 0.52, 95%CI: 0.49, 0.71), birth at home (aIRR = 0.27, 95% CI: 0.17, 0.34), living in rural area (aIRR = 0.39, 95% CI: 0.24, 0.57) were significant predictors of ENC uptake.

Conclusion
The level of missing ENC was found to be high in Ethiopia with a significant spatial variation across regions. Hence, the government and policymakers should devise strategies for hotspot areas to improve women’s economic capabilities, access to education, and health-seeking behaviours for prenatal care and skilled delivery services to improve ENC uptake.
Profile of individuals served and presumed coverage of Psychosocial Care Centers (CAPS) in Brazil: A study of the period 2013–2019
Authors: Paiva do Carmo Mercedes Bruna , Silva Everton Nunes da , Carregaro Rodrigo Luiz , Miasso Adriana Inocenti 
Published: September 2024

Objective
To describe the profile of individuals with depression who received assistance at CAPS in Brazil between 2013 and 2019, focusing on their clinical and demographic characteristics, and to calculate the estimated coverage of CAPS across the national territory and its constituent federal units.

Methods
Descriptive, ecological, time-series study with secondary data from national databases, referring to care provided at CAPS in the country for adults aged 18 years or over-diagnosed with depression (F32-32.9 and F33-F33.9). The estimated coverage of CAPS was calculated for 2013 and 2019 using registered and active services.

Results
There was a 107% increase in the number of patients with depression receiving treatment at CAPS between 2013 and 2019. Women accounted for 77% of the patients, with the majority falling within the age range of 41 to 61years (49%). The predominant racial demographics were white (38%) and brown (34%). The diagnosis of depressive episodes was prevalent among 65% of the patients, and individual care was administrated to 75% of them. The presumed CAPS coverage was 71% in 2013 and increased to 87% in 2019 nationwide, although significant discrepancies were observed among different states.

Conclusion
Progress was evident in the implementation of CAPS across Brazil during the period spanning 2013 to 2019. Nonetheless, disparities persist among the federative units, and there remains an underutilization of group and family care within CAPS services.