bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissipation and diamagnetic effects on the interchange mode growth rate and rotation in reduced magnetohydrodynamics applied to stellarators
Authors: Nicolas T. , Ichiguchi K. 
Published: December 2015

Abstract
The results of a reduced magnetohydrodynamic model for the interchange mode in a stellarator are reported. The model is based on Strauss equations, with the addition of resistivity, viscosity and perpendicular heat conductivity on the one hand, and ion and electron diamagnetic effects on the other hand. The ideally unstable and stable mode growth rate and frequency are studied. The main result is that the ideally unstable mode can rotate in the electron direction even in the absence of electron diamagnetic effects, due to a linear bifurcation caused by the heat conductivity. The presence of the bifurcation is explained analytically. The diamagnetic effects can be destabilizing. For the ideally stable (resistive) mode, we find that the presence of viscosity and heat conductivity causes rotation in the electron direction in the case where

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A Randomized Trial of a Low-Fat Diet Intervention on Blood Pressure and
Hypertension: Tertiary Analysis of the WHI Dietary Modification Trial
Authors: Allison Matthew A. , Aragaki Aaron K. , Ray Roberta M. , Margolis Karen L. , Beresford Shirley A.A. , Kuller Lewis , Jo O’Sullivan Mary , Wassertheil-Smoller Sylvia , Van Horn Linda 
Published: December 2015

Abstract

BACKGROUND
This post hoc analysis determined if the Women’s Health Initiative (WHI) Diet Modification intervention (DM-I) resulted in a significantly different rate of incident hypertension (HTN), as well as longitudinal changes in blood pressure.

METHODS
Participants were 48,835 postmenopausal women aged 50–79 years who were randomly assigned to either the intervention or comparison group. HTN was defined as self-report of treated HTN collected semiannually or blood pressure ≥140/90mm Hg at one of the annual follow-up clinic visits.

RESULTS
After a mean follow-up of 8.3 years, and among those who did not have HTN at baseline ( n = 31,146), there were 16,174 (51.9%) HTN cases and those assigned to the intervention group had a 4% lower overall risk of developing incident HTN (hazard ratio (HR): 0.96, 95% confidence interval (CI): 0.93–0.99). Although the risk of HTN was lower in the DM-I group in the first few years, the HR became greater than 1 after year 5 ( P -trend &lt; 0.01). Similarly, randomization to the DM-I arm resulted in a small but significantly lower average systolic blood pressure (SBP) at 1 year of follow-up (−0.66mm Hg, 0.44–0.89) that increased over the following 8 years (0.16mm Hg/year, 0.11–0.21), such that any early benefit was eliminated by year 5 and a minimal deleterious effect emerged by year 7.

CONCLUSION
Randomization to an intensive behavioral dietary modification program aimed at a lower total fat intake is not associated with sustained reductions in blood pressure or risk of HTN in postmenopausal women.

CLINICAL TRIAL REGISTRATION
url http://www.clinicaltrials.gov , unique identifier nct00000611
rCGH: a comprehensive array-based genomic profile platform for precision medicine
Authors: Commo Frederic , Guinney Justin , Ferté Charles , Bot Brian , Lefebvre Celine , Soria Jean-Charles , André Fabrice 
Published: December 2015

Abstract
Summary: We present rCGH, a comprehensive array-based comparative genomic hybridization analysis workflow, integrating computational improvements and functionalities specifically designed for precision medicine. rCGH supports the major microarray platforms, ensures a full traceability and facilitates profiles interpretation and decision-making through sharable interactive visualizations.
Availability and implementation: The rCGH R package is available on bioconductor (under Artistic-2.0). The aCGH-viewer is available at https://fredcommo.shinyapps.io/aCGH_viewer, and the application implementation is freely available for installation at https://github.com/fredcommo/aCGH_viewer.
Contact: frederic.commo@gustaveroussy.fr
Supplementary information: Supplementary data are available at Bioinformatics online.
Fast and efficient QTL mapper for thousands of molecular phenotypes
Authors: Ongen Halit , Buil Alfonso , Brown Andrew Anand , Dermitzakis Emmanouil T. , Delaneau Olivier 
Published: December 2015

AbstractMotivation: In order to discover quantitative trait loci, multi-dimensional genomic datasets combining DNA-seq and ChiP-/RNA-seq require methods that rapidly correlate tens of thousands of molecular phenotypes with millions of genetic variants while appropriately controlling for multiple testing.Results: We have developed FastQTL, a method that implements a popular cis-QTL mapping strategy in a user- and cluster-friendly tool. FastQTL also proposes an efficient permutation procedure to control for multiple testing. The outcome of permutations is modeled using beta distributions trained from a few permutations and from which adjusted P-values can be estimated at any level of significance with little computational cost. The Geuvadis & GTEx pilot datasets can be now easily analyzed an order of magnitude faster than previous approaches.Availability and implementation: Source code, binaries and comprehensive documentation of FastQTL are freely available to download at http://fastqtl.sourceforge.net/Contact: emmanouil.dermitzakis@unige.ch or olivier.delaneau@unige.chSupplementary information: Supplementary data are available at Bioinformatics online.
HitWalker2: visual analytics for precision medicine and beyond
Authors: Bottomly Daniel , McWeeney Shannon K. , Wilmot Beth 
Published: December 2015

Abstract
Summary: The lack of visualization frameworks to guide interpretation and facilitate discovery is a potential bottleneck for precision medicine, systems genetics and other studies. To address this we have developed an interactive, reproducible, web-based prioritization approach that builds on our earlier work. HitWalker2 is highly flexible and can utilize many data types and prioritization methods based upon available data and desired questions, allowing it to be utilized in a diverse range of studies such as cancer, infectious disease and psychiatric disorders.
Availability and implementation: Source code is freely available at https://github.com/biodev/HitWalker2 and implemented using Python/Django, Neo4j and Javascript (D3.js and jQuery). We support major open source browsers (e.g. Firefox and Chromium/Chrome).
Contact: wilmotb@ohsu.edu
Supplementary information: Supplementary data are available at Bioinformatics online. Additional information/instructions are available at https://github.com/biodev/HitWalker2/wiki
simDEF: definition-based semantic similarity measure of gene ontology terms for functional similarity analysis of genes
Authors: Pesaranghader Ahmad , Matwin Stan , Sokolova Marina , Beiko Robert G. 
Published: December 2015

Abstract
Motivation: Measures of protein functional similarity are essential tools for function prediction, evaluation of protein–protein interactions (PPIs) and other applications. Several existing methods perform comparisons between proteins based on the semantic similarity of their GO terms; however, these measures are highly sensitive to modifications in the topological structure of GO, tend to be focused on specific analytical tasks and concentrate on the GO terms themselves rather than considering their textual definitions.
Results: We introduce simDEF, an efficient method for measuring semantic similarity of GO terms using their GO definitions, which is based on the Gloss Vector measure commonly used in natural language processing. The simDEF approach builds optimized definition vectors for all relevant GO terms, and expresses the similarity of a pair of proteins as the cosine of the angle between their definition vectors. Relative to existing similarity measures, when validated on a yeast reference database, simDEF improves correlation with sequence homology by up to 50%, shows a correlation improvement &gt;4% with gene expression in the biological process hierarchy of GO and increases PPI predictability by &gt; 2.5% in F1 score for molecular function hierarchy.
Availability and implementation: Datasets, results and source code are available at http://kiwi.cs.dal.ca/Software/simDEF
Contact: ahmad.pgh@dal.ca or beiko@cs.dal.ca
Supplementary information: Supplementary data are available at Bioinformatics online.
Depression and the risk of severe infections: prospective analyses on a nationwide representative sample
Authors: Andersson Niklas W , Goodwin Renee D , Okkels Niels , Gustafsson Lea N , Taha Farah , Cole Steve W , Munk-Jørgensen Povl 
Published: December 2015

Abstract
Background : Preliminary research suggests an association between depression and subsequent increased risk of infections, yet little is known on this topic. This study investigated the association between depression and risk of various types of infections, including temporal and dose-response relationships.
Methods : A prospective population-based study including 976 398 individuals, of whom 142 169 had a history of depression between 1995 and 2012, was conducted using linked Danish registries. Survival analyses were used to estimate the relative risk of infections among those with depression, compared with those without depression, while adjusting for gender and age.
Results : Depression was associated with increased risk of a wide range of infections [incidence rate ratio (IRR) = 1.61, 95% confidence interval (CI) = 1.49–1.74, P  = 0.000, for any infection]. There was no evidence of a specific temporal effect but rather a general increased risk of infection subsequent to the onset of depression, as the risk during first year (IRR = 1.67, 95% CI = 1.25–2.22, P = 0.000) remained elevated for the ensuing 11 years and beyond (IRR = 1.61, 95% CI = 1.39–1.85, P = 0.000). Dose-response analyses revealed that the risk of infection increased by 59% (IRR = 1.59, 95% CI = 1.45–1.75, P  = 0.000) following a single depressive episode and was elevated even further (IRR = 1.97, 95% CI = 0.92–4.22, P  = 0.082) following four or more depressive episodes. However, results did not indicate a perfect linear association.
Conclusions : Findings suggest the presence of depression may confer an increased risk of infection and that this increased susceptibility is not confined to a specific time period following the onset of depression. A dose-response relationship may be present, but more research is needed to further examine and confirm a link between depression and risk of infection.
Reasoning about opinion dynamics in social networks
Authors: Hansen Jens Ulrik 
Published: December 2015

AbstractThis article introduces a logic to reason about a well-known model of opinion dynamics in social networks initially developed by Morris DeGroot as well as Keith Lehrer and Carl Wagner. The proposed logic is an extension of Łukasiewicz' fuzzy logic with additional equational expressivity, modal operators, machinery from hybrid logic and dynamic modalities. The model of opinion dynamics in social networks is simple enough to be easily grasped, but still complex enough to have interesting mathematical properties and applications. Thus, developing a logic to reason about this particular model serves as a paradigmatic example of how logic can be useful in social network analysis.
Strongyloidiasis With Severe Malnourishment and Hyponatremia After Suboptimal Antihelminthic Therapy
Authors: Barber Grant E. , Ganatra Rahul B. , Bortinger Jonathan Z. , Hale Andrew J. 
Published: December 2015

Abstract
We report a 73-year-old woman from Dominica with anorexia and weight loss who was found to have strongyloides infection on esophagogastroduodenoscopy and subsequently was treated with 40 μg/kg of ivermectin for 2 days, although most experts recommend 200 μg/kg. An incidental stage 1 endometrial carcinoma was found, and hysterectomy was performed with postoperative dexamethasone for nausea. Her vomiting worsened, and she re-presented to the hospital with anasarca, severe hyponatremia, and oral intolerance. The syndrome of inappropriate antidiuretic hormone secretion was suspected based on elevated urine osmolarity and nonresponse to intravenous normal saline. Repeat endoscopy demonstrated severe duodenitis with ulcerations, and biopsy confirmed a high burden of strongyloidiasis. She was treated with ivermectin at 200 μg/kg daily for 7 days with complete symptom resolution. High suspicion for strongyloides infection should be exercised for patients from endemic areas with chronic gastrointestinal symptoms, wheezing, and/or hypereosinophilia, and corticosteroids must be avoided to prevent dissemination.
Experimental and theoretical studies of hydralazine hydrochloride as corrosion inhibitor for mild steel in HCl acid medium
Authors: Prasanna B.M. , Praveen B.M. , Hebbar Narayana , Venkatesha T.V. 
Published: December 2015

Purpose– The purpose of this paper is to investigate the inhibition effect of hydralazine hydrochloride as a corrosion inhibitor for mild steel in 1M HCl. The inhibition effect was studied at different temperatures, ranging from 303 to 333°K.Design/methodology/approach– The inhibition efficiency of hydralazine hydrochloride was analyzed using weight loss, Tafel polarization, electrochemical impedance spectroscopy and surface morphology methods. The effect of temperature on the corrosion behavior of mild steel in 1M HCl was studied and discussed using an adsorption isotherm and activation parameters.Findings– Weight loss, polarization and impedance showed that the inhibition efficiency increases with an increase in the concentration of hydralazine hydrochloride for mild steel in 1M HCl. The inhibitive action may be attributed to the adsorption of the inhibitor molecule on the active sites of the metal surface by the Langmuir adsorption isotherm. Polarization curves indicated that hydralazine hydrochloride acts as a mixed-type inhibitor. Scanning electron microscopy was performed on inhibited and uninhibited mild steel samples to characterize the surface. Thermodynamic parameter indicated that the adsorption of hydralazine hydrochloride is a spontaneous process and the adsorption occurs chemically.Originality/value– The inhibition effect of hydralazine hydrochloride for mild steel has been investigated at different temperatures, ranging from 303 to 333°K. Hydralazine hydrochloride was a good inhibitor at a higher temperature.
Study on the corrosion protection performance of new ferrite/kaolin core-shell pigments in epoxy-based paints
Authors: Ahmed Nivin M , Abd El-Gawad Walaa M. , Souaya Eglal R. 
Published: December 2015

Purpose
– The purpose of this study is to prepare core-shell ferrites/kaolin pigments and compare their efficiency in protecting metal substrates to original ferrites. The new pigments are based on precipitating a shell of different ferrites that comprise only 10-20 per cent of the whole pigment on kaolin (core), which is a cheap and abundant ore comprising 80-90 per cent of the prepared pigment. These new pigments combine the properties of both its core and shell counter-parts, exhibiting improved corrosion protection properties. Furthermore, the pigments are represented as efficient, economically feasible and eco-friendly with comparable efficiency to that of original ferrites in protecting steel substrates.

Design/methodology/approach
– The new pigments were characterized using different analytical and spectrophotometric techniques, e.g. transmission electron microscopy, energy-dispersive X-ray analysis and X-ray fluorescence. The pigments were then incorporated in epoxy-based paint formulations. The physico-mechanical properties of dry films and their corrosion properties were tested using accelerated laboratory tests in 3.5 per cent NaCl for 28 days.

Findings
– The results of this study revealed that ferrite/kaolin core-shell pigments performance was almost close to that of the ferrite pigments in the protection of steel, and, at the same time, they confirmed good physico-mechanical properties.

Practical implications
– These pigments can be applied in other polymer composites, e.g. rubber and plastics, as fillers and reinforcing agents.

Originality/value
– Ferrite and ferrite/kaolin are environmentally friendly pigments, and they can impart high anticorrosive behavior to paint films with concomitant cost savings.
How servant leadership nurtures knowledge sharing
Authors: Tuan Luu Trong 
Published: December 2015

Purpose– When knowledge is shared, it flows beyond individual level to add to organizational knowledge. The purpose of this paper is to seek an insight into the role of servant leadership in leveraging knowledge sharing among public employees, thereby enriching organizational knowledge in public organizations. The study also investigates the individual-level mediation effect of public service motivation (PSM), as well as organization-level moderating effect of corporate social responsibility (CSR) for the relationship between servant leadership and knowledge sharing.Design/methodology/approach– The data on the research variables were collected from 562 employees and 197 department managers in public organizations of electricity, telephone, and water industries in Vietnam context.Findings– Research results provided evidence for the mediating effect of PSM for the servant leadership-knowledge sharing linkage. This linkage was also found to be positively moderated by CSR.Originality/value– This research extends PSM literature by shedding light on the mediating role of PSM for the effect of servant leadership on knowledge sharing, thereby demonstrating the convergence of servant leadership, knowledge sharing, and PSM research streams.
The relationship between trust in work colleagues, impact of boundary violations and burnout among staff within a forensic psychiatric service
Authors: Johnson Helen , Worthington Rachel , Gredecki Neil , Wilks-Riley Fiona Rachel 
Published: December 2015

Purpose
– The purpose of this paper is to examine the relationship between trust and burnout among mental health professionals working within a forensic psychiatric setting. The association between these factors and boundary violations was also examined.

Design/methodology/approach
– Mental health professionals (n=117) completed the Maslach Burnout Inventory and a measure of their trust in co-workers. A series of 12 vignettes was also designed to assess the frequency and impact of boundary violations by clients.

Findings
– Propensity to trust was found to be predictive of personal accomplishment. A higher propensity to trust others was associated with lower levels of emotional exhaustion and depersonalisation. It was also associated with greater cooperative behaviour. Higher frequency of boundary violations reported by professionals was associated with lower levels of perceived trust and cooperative behaviours among colleagues, and increased depersonalisation. In addition, professionals reporting more of a perceived impact of boundary violations, reported higher emotional exhaustion and depersonalisation. The results also indicate that younger professionals reported higher levels of emotional exhaustion and depersonalisation, whereas older professionals were more positive regarding their competence and sense of accomplishment.

Research limitations/implications
– The results are discussed in terms of the development of trust within teams as an effective strategy to reduce the development of burnout. Implications are made for the importance of reflective practice and clinical supervision in developing positive working relationships with clients, and providing a safe environment to discuss professional conflict. The importance of supporting younger professionals has also been highlighted.

Originality/value
– This is the first research paper to explore the relationship between trust within teams and the development of burnout within forensic psychiatric services.
Rwanda
Authors: Dusabe Francis 
Published: December 2015

Purpose
– This paper aims to assess the extent to which Rwanda is prepared to deal with the menace of money laundering, a threat that may well stunt its ambitions to build a strong economy.

Design/methodology/approach
– This paper used desktop research based on primary and secondary sources. It is based on a review of relevant conventions laws and policies constituting the anti-money laundering legal regime.

Findings
– Rwanda’s responses are not strong enough to curb the ever growing risk of money laundering. Rwandan economic structure may easily accommodate launderers, given the development policies relating to investments positive political will may help to pre-empt the increase in the crime.

Originality/value
– Neither academic, editorial or any work whatsoever have been conducted regarding Money Laundering in Rwanda nor has the prosecution ever submitted a case in the courts at least to pave the prosecutorial strategy in the cases of money laundering. This work is of its own and has been reviewed by well-known professors in the domain, namely, Prof Lovell Fernandez, the Director of South African Germany Center for Transnational Criminal Justice.
The influence of market orientation on innovation strategies
Authors: Newman Alexander , Prajogo Daniel , Atherton Andrew 
Published: December 2015

Purpose– The purpose of this paper is to examine the effects of market orientation on exploratory and exploitative innovation, and the moderating effects of family ownership on these relationships.Design/methodology/approach– This study utilizes multi-group path analysis and confirmatory factor analysis in LISREL on data from 228 firms in the Australian service sector.Findings– This study establishes that both customer and competitor innovation are positively related to exploitative and exploratory innovation. However, customer orientation does not lead to significantly stronger effects on exploitative innovation than on exploratory innovation, and competitor orientation does not lead to significantly stronger effects on exploratory innovation than on exploitative innovation. In addition, the study found that the relationship between customer orientation and exploratory innovation was stronger for family firms, while the relationships between competitor orientation and both exploratory and exploitative innovation were stronger for non-family firms.Research limitations/implications– The cross-sectional design is one weakness of this study. In addition, as firms in the present study came from the service sector the generalizability of the findings to other sectors of the economy need to be determined.Practical implications– These findings of this study highlight the need for managers to build a strong market orientation in order to promote innovation, and consider the effects of ownership structure on innovation strategies.Originality/value– This study is the first to measure the relative influence of customer and competitor orientation on a firm’s use of exploitative and exploratory innovation strategies.