bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy, an Update From the International PSOGI Registry
Authors: Duran‐Martínez M. , Bergillos‐Giménez M. , Rodríguez‐Ortíz L. , Arjona‐Sánchez A. ,   Laparoscopic PSOGI Registry
Published: September 2024

ABSTRACTIntroductionCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are established treatments for peritoneal surface malignancies, traditionally performed via laparotomy. Recent advancements in laparoscopic approaches (L‐CRS + HIPEC) have shown promising results in selected patients.MethodsThe PSOGI registry, established in November 2019, collects data from specialized centers performing L‐CRS + HIPEC. Data were collected prospectively and analyzed retrospectively, excluding risk‐reducing procedures without peritoneal disease. The learning curve was assessed using a 14‐cases cutoff.ResultsToday, 323 patients have been registered, 193 were included finally. Perioperative outcomes improved after 14 cases: Length of hospital stay was 7.78 ± 3.64 days (consolidation) versus 8.8 ± 8.79 days (learning) and major morbidity was 0% (consolidation) versus 5% (learning), (p = n.s.). Estimated blood loss was lower in the consolidation phase. Oncological outcomes also improved: Recurrence rate was 8.7% (consolidation) versus 17.8% (learning). Disease‐free survival 5 years, 65% (learning) versus 88% (consolidation) (p = 0.012).ConclusionThe L‐CRS + HIPEC is a safe procedure with non‐inferior oncologic outcomes which it is evaluating in an IDEAL setting by an international group. The validation of the learning curve, gives us the knowledge that a mentoring program must be setup to reduce the learning curve impact in oncologic failure.
Evaluation of Sonographic Muscle Measurement Using Established Muscle Markers
Authors: Kremer Wolfgang Maximilian , Schwarz Alexander , Schepers Markus , Labenz Christian , Hahn Felix , Sivanathan Visvakanth , Düber Christoph , Galle Peter Robert , Sprinzl Martin Franz 
Published: September 2024

ObjectivesLoss of muscle quantity and function is associated with frailty and reduced quality of life. Sonography is a simple option to quantify muscle mass, which could be included into routine diagnostic workup. This study was designed to prospectively evaluate sonographic measurement and to compare it with established measurements of muscle quantity and function.MethodsBetween March 2020 and May 2022, 723 patients were enrolled in the study. Psoas muscle area index (PMAI) and psoas muscle thickness height index (PMTI) were quantified. Thigh muscle thickness indices (TMTI) were either measured without compression (fTMTI) or under compression (cTMTI). Variation coefficient (VC) as well as intra‐ and inter‐observer reliability were analyzed. The reliability and reproducibility of the sonographic morphometry were assessed using two examiners. Sonographic morphometry was compared with established measurements of muscle using computed tomography and hand grip strength, respectively.ResultsIn 156 patients, sonographic indices were compared with corresponding CT indices. Of the 723 patients included, sonographic indices were compared with hand strength in 429 patients. Interobserver and intraobserver variability showed better results for the femur indices than for the psoas indices (correlation coefficient: 0.8697/0.9118 vs 0.7502/0.7319). Psoas muscle indices correlated best with the reference standard of the SMI. The optimal cut‐off for each muscle index for determining muscle loss according to the SMI and hand grip strength was calculated.ConclusionSonography can simplify muscle measurement and should be used in the future. Sonographic muscle indices have the potential to simplify evaluation, especially in risk groups such as patients with liver cirrhosis or other wasting disorders.
Color‐Tunable Emission via Site‐Selective Occupation of Eu2+ Activators in Silicate Phosphors
Authors: Yang Yuzhu , Zhang Peng , Miao Xuan , Lin Zenggang , Li Sixia , Liu Weisheng 
Published: September 2024

AbstractSite‐selective occupation generated by ion doping into crystal lattices is an effective way to explore new matter and regulate luminescent properties. Herein, equiv. M2+ (Ca, Sr, Ba) is partially replaced each other to formulate multiple doped sites in Li2MSiO4: Eu2+ (LMSO: Eu2+). As the luminescence center, Eu2+ selectively occupies different sites to regulate luminescent color in the visible spectrum ranging from blue to orange, and ultimately functionality improvement. The Huang‐Rhys factor is quite small and the resulting phosphors display an ultrahigh thermal stability for optical thermometry. Besides, utilizing synthesized phosphors combined with the InGaN chip generates high‐quality full‐spectrum white light. Under X‐ray irradiation, LMSO: Eu2+ (M = Ca, Sr, Ba) exhibits great X‐ray imaging ability, the detection limit of X‐ray reaches 0.18, 0.075, and 0.12 µGy s−1. This work presents great potentiality of synthesized phosphors in the fields of solid‐state lighting and X‐ray imaging.
The Implication of Photodynamic Therapy Applied to the Level of Tumor Resection on Postoperative Cerebral Edema and Intracranial Pressure Changes in Gliomas
Authors: Li Jingxuan , Sun Weijun , Hu Shaoshan , Yan Xiuwei 
Published: September 2024

ABSTRACTAimThe aim of our study was to explore the factors influencing cerebral edema and intracranial pressure in glioblastoma multiforme (GBM) patients who undergo photodynamic therapy (PDT) after resection.ApproachThis was a retrospective controlled study of GBM patients treated with PDT‐assisted resections of varying scope from May 2021 to August 2023. The baseline clinical data, cerebral edema volumes, intracranial pressure values, and imaging data of the GBM patients were collected for statistical analysis.ResultsA total of 56 GBM patients were included. Thirty of the patients underwent gross total resection (GTR), and the other 26 patients underwent subtotal resection (STR). We found that the cerebral edema volume and the mean intracranial pressure in patients who underwent GTR were lower than those in patients who underwent STR. Moreover, univariate analysis showed that the scope of tumor resection was an independent factor affecting cerebral edema and intracranial pressure after PDT.ConclusionsCompared with STR, PDT combined with GTR significantly reduced postoperative brain edema volume and intracranial pressure in GBM patients.
Knockdown of PAIP1 Inhibits Breast Cancer Cell Proliferation by Regulating Cyclin E2 mRNA Stability
Authors: Yang Wenqing , Wang Qingkun , Li Qi , Han Yue , Zhang Yu , Zhu Lu , Zhu Lianhua , Piao Junjie 
Published: September 2024

ABSTRACTPolyadenylate‐binding protein‐interacting protein 1 (PAIP1) is a protein that modulates translation initiation in eukaryotic cells. Studies have shown that PAIP1 was overexpressed in various type of cancers, and drives cancer progression by promoting cancer cell proliferation, invasion, and migration. In our previous study, we identified that PAIP1 was overexpressed in breast cancer, and the expression was correlated with poor prognosis. However, the biological function of PAIP1 in breast cancer has not been clearly understood. In this study, we constructed PAIP1 specifically silenced breast cancer cells. Then, cell proliferation, cell cycle distribution, and apoptosis were detected in PAIP1 knockdown cells. RNA‐seq analysis was performed to predict the downstream target of PAIP1, and the molecular mechanism was explored. As a results, we found that knockdown of PAIP1 repressed cell proliferation, induced cell cycle arrest, and triggers apoptosis. Xenograft mouse model showed that knockdown of PAIP1 inhibits cell growth in vivo. RNA‐seq predicted that CCNE2 mRNA was one of the downstream targets of PAIP1. In addition, we identified that knockdown of PAIP1‐inhibited cell proliferation through modulating cyclin E2 expression. Mechanically, knockdown of PAIP1 reduces the expression of cyclin E2 by regulating the mRNA stability of cyclin E2. Moreover, in breast cancer tissues, we found that the expression of PAIP1 was positively correlated with cyclin E2. Taken together, our findings establish the role and mechanism of PAIP1 in breast cancer progression, indicating that PAIP1 would be a new therapeutic target for breast cancer treatment.
Consensus Guidance for Genetic Counseling in GBA1 Variants: A Focus on Parkinson's Disease
Authors: Vieira Sophia R.L. , Mezabrovschi Roxana , Toffoli Marco , Del Pozo Sara Lucas , Menozzi Elisa , Mullin Stephen , Yalkic Selen , Limbachiya Naomi , Koletsi Sofia , Loefflad Nadine , Lopez Grisel J. , Gan‐Or Ziv , Alcalay Roy N. , Sidransky Ellen , Schapira Anthony H.V. 
Published: September 2024

AbstractGlucocerebrosidase (GBA1) variants constitute numerically the most common known genetic risk factor for Parkinson's disease (PD) and are distributed worldwide. Access to GBA1 genotyping varies across the world and even regionally within countries. Guidelines for GBA1 variant counseling are evolving. We review the current knowledge of the link between GBA1 and PD, and discuss the practicalities of GBA1 testing. Lastly, we provide a consensus for an approach to counseling people with GBA1 variants, notably the communication of PD risk. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
The added value of diffusion tensor imaging with systematic bias correction for the assessment of liver morphology and physiology
Authors: Mazur‐Rosmus Weronika , Spees William M. , Krzyżak Artur T. 
Published: September 2024

AbstractDiffusion‐weighted images of the human liver are prone to artifacts from bulk motions, poor SNR, non‐uniformity of magnetic field gradients, and non‐optimal choice of diffusion weightings. These factors markedly affect diffusion tensor imaging (DTI) metrics such as mean diffusivity (MD) and fractional anisotropy (FA).This work presents a simple preprocessing pipeline for enhanced magnetic field gradient non‐uniformity calibration and analysis of the systematic bias removal attained in each correction step.Liver DTI scans were conducted in two isotropic phantoms and one healthy volunteer. Diffusion tensor was calculated for the original data and after denoising, B1 correction, rigid body registration, and magnetic field gradient non‐uniformity correction applying the B‐matrix spatial distribution (BSD) method and then, compared with the standard approach (sDTI). MD and FA were determined in three segments of the right lobe from DTI using four different combinations of b‐values from the set 0, 400, and 800 s/mm2.Results showed that the proposed preprocessing and BSD methods have a significant impact on MD and FA values in off‐ and iso‐centered isotropic phantoms. The applied corrections applied to the human liver resulted in a 11% change in MD and a − 64% change in FA. By manipulating the b‐values used in the diffusion tensor calculation, DTI metrics that reflect only morphology or additional information about liver tissue physiology can be obtained.Accurate quantification of the human liver by diffusion requires appropriate preprocessing and carefully chosen b‐value.Noise, B1 inhomogeneity, mis‐registration, and non‐uniform magnetic field gradients significantly change distributions of DTI metrics in isotropic phantoms and the human liver. Basic preprocessing and the B‐matrix spatial distribution (BSD) method perform differently for off‐center and isocenter locations. In the human liver, they removed systematic bias of FA and MD by up to −63% and 11%, respectively. Visible variability of FA and MD among b‐value sets indicates the possibility of DTI sensitization to different liver compartments.
Description of the etiological factors behind acute moderate and severe malnutrition in children under 5 years hospitalized at two high‐complexity referral centers: Case series
Authors: Olarte‐Bernal Mónica , Guevara‐Santamaría Fabian Ricardo , Jacome‐Suarez Jennyfer Carolina , Palacios‐Ariza María Alejandra , Medina‐Parra Jorge , Merchán‐Chaverra Ricardo Alfonso , Cuellar‐Fernandez Yeny Marjorie 
Published: September 2024

AbstractBackgroundAcute malnutrition in children <5 years of age has a direct relationship with medical complications and mortality. We aimed to describe the etiologic factors in children with moderate and severe non–illness‐related acute malnutrition who required hospitalization for treatment of malnutrition in two high‐complexity hospital centers in Bogotá, Colombia.MethodsThis is a multicenter case series (December 2016 to December 2020) including patients aged 1–59 months with a weight/height indicator less than −2 SD. Electronic health records were reviewed, and demographic (sex, age, city of origin, and socioeconomic status) and clinical data (gestational age at birth, edema, and nutrition status) were collected. Descriptive analysis of information was performed. An exploratory bivariate analysis by diagnostic categories of moderate and severe acute malnutrition vs days of hospitalization was also performed.ResultsForty‐five patients were included, 62.2% of whom were male, with a median age of 14 months (Q1–Q3: 7–24). The main etiologic factors of malnutrition were related to problems with total food intake (33.3%), transition in consistency of feeding (31.1%), and breastfeeding technique (22.2%). Only 13.3% had problems related to food insecurity. There were no statistically significant differences between moderate (median: 7 days; Q1–Q3: 5–12) and severe (median: 8 days; Q1–Q3: 5–16) acute malnutrition when compared by days of hospitalization.ConclusionsThe main etiologic factors of malnutrition in our study population were related to problems in the amount of food provided and transition in consistency of complementary feeding.
A group prenatal care intervention reduces gestational weight gain and gestational diabetes in American Samoan women
Authors: Hawley Nicola L. , Faasalele‐Savusa Kima , Faiai Mata'uitafa , Suiaunoa‐Scanlan Lynette , Loia Miracle , Ickovics Jeannette R. , Kocher Erica , Piel Christopher , Mahoney Madison , Suss Rachel , Trocha Marcela , Rosen Rochelle K. , Muasau‐Howard Bethel T. 
Published: September 2024

AbstractObjectiveThe objective of this study was to determine the preliminary effectiveness of an intervention to mitigate adverse pregnancy outcomes associated with pre‐pregnancy obesity in American Samoa.MethodsWe enrolled n = 80 low‐risk pregnant women at <14 weeks' gestation. A complete case analysis was conducted with randomized group assignment (group prenatal care‐delivered intervention vs. one‐on‐one usual care) as the independent variable. Primary outcomes were gestational weight gain and postpartum weight change. Secondary outcomes included gestational diabetes screening and exclusive breastfeeding at 6 weeks post partum. Other outcomes reported include gestational diabetes incidence, preterm birth, mode of birth, infant birth weight, and macrosomia.ResultsGestational weight gain was lower among group versus usual care participants (mean [SD], 9.46 [7.24] kg vs. 14.40 [8.23] kg; p = 0.10); postpartum weight change did not differ between groups. Although the proportion of women who received adequate gestational diabetes screening (78.4% group; 65.6% usual care) was similar, there were clinically important between‐group differences in exclusive breastfeeding (44.4% group; 25% usual care), incidence of gestational diabetes (27.3% group; 40.0% usual care), and macrosomia (8.3% group; 29.0% usual care).ConclusionsIt may be possible to address multiple risk factors related to intergenerational transmission of obesity in this high‐risk setting using a group care‐delivered intervention.
Advancement of constant and progressive load multi‐cycle indentation method on surface properties characterization of polymers
Authors: Guru Soumya Ranjan , Sarangi Mihir 
Published: September 2024

AbstractIn recent years, polymers have been popular in industrial applications due to their lightweight, corrosion‐resistant, improved surface polish, ease of manufacturing, cost‐effectiveness, and so forth. Similarly, micro/nano‐indentation has gained popularity as a technique for assessing the surface mechanical characteristics of polymers. The present study conducted comprehensive experiments using cyclic micro‐indentation on engineering polymers, specifically poly‐ether‐ether‐ketone (PEEK), poly(methyl methacrylate) (PMMA), and poly(tetra‐fluoroethylene) (PTFE). An appropriate and optimal indentation method has been proposed after analyzing the behavior and significance of all the input parameters in evaluating the properties. Both constant load multi‐cycle (CLMC) and progressive load multi‐cycle (PLMC) were considered for this investigation. A comparative evaluation has been conducted to assess two multi‐cycle tests on these materials. From the analysis of the input parameters, including maximum loads, loading and unloading rates, and the number of cycles, the unloading rate and indentation cycle are crucial factors in determining hardness (H) and elastic modulus (E). Increasing the loading rates leads to an increase in H and a reduction in E for all three materials. This effect arises from the thermal effect, which is characterized by the creep modulus and a closed hysteresis loop. Employing the holding duration and multiple cycle data in constant load multi‐cycle can significantly influence the creep behavior and use of the hysteresis loop for fatigue behavior. Similarly, a progressive load multi‐cycle indentation with a force greater than 0.5 N and a minimum of five cycles is the most accurate approach for evaluating surface mechanical parameters.
Synergistic toughening effects of elastomer toughener and nucleating agent on mechanical properties and crystallization behaviors of polypropylene
Authors: Yin Ziwen , Wei Deyu , Lin Qing , Tian Hanlin , Yu Jinshuo , Li Yanbo , Deng Huiwen , Wang Zepeng , Pan Hongwei , Zhao Yan , Zhang Huiliang 
Published: September 2024

AbstractA novel thermoplastic elastomer, kernel resin (KN), α‐nucleating agent (HPN), and β‐nucleating agent (DCHT), which acted as toughener and nucleating agents (NAs), were used to improve the mechanical properties and crystallization behaviors of isotactic polypropylene (PP). The impact strength of the PP/KN blends increased significantly with increase in KN concentration. Surprisingly, the impact strength of PP/KN/NA blends improved further upon addition of NA. The toughening effect of DCHT was stronger than that of HPN. The maximum impact strength of PP/KN/DCHT blend reached 69.2 kJ/m2 when the DCHT content was 0.05%, which was six times higher than that of neat PP. The SEM images of fractured surfaces of the blends showed a change from brittle fracture to ductile fracture. Moreover, the WAXD results showed that the incorporation of HPN promoted the formation of the α form of crystalline PP. Addition of DCHT induced the generation of α‐β crystal transition of PP. Furthermore, differential scanning calorimetry showed that the crystallizability and the overall crystallization rate of PP were enhanced by the addition of KN and NA. The half‐crystallization time of PP at 128°C decreased from 5.52 (neat PP) to 0.34 min (PP/KN/DCHT‐0.3).
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features
Authors: Mitra Shamik , Farswan Akanksha , Piccinelli Paul , Sydow Saskia , Hesla Asle , Tsagkozis Panagiotis , Vult von Steyern Fredrik , Almqvist Martin , Eriksson Mikael , Magnusson Linda , Nilsson Jenny , Pillay Nischalan , Mertens Fredrik 
Published: September 2024

AbstractMyxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are two common and aggressive subtypes of soft tissue sarcoma. The aim of this study was to assess potential transcriptomic differences between MFS and UPS tumours and to evaluate the extent to which differences in gene expression profiles were associated with genomic and clinical features. The study included 162 patients with tumours diagnosed as MFS (N = 62) or UPS (N = 100). The patients had been diagnosed and treated at two Swedish sarcoma centres during a 30‐year period. For gene expression profiling and gene fusion detection all tumours were analysed using RNA‐sequencing and could be compared with data on clinical outcome (N = 155), global copy number profiles (N = 145), and gene mutations (N = 128). Gene expression profiling revealed three transcriptomic clusters (TCs) without any clear separation of MFS and UPS. One TC was associated with longer metastasis‐free survival. These tumours had lower tumour mutation burden (TMB), were enriched for a copy number signature representative of focal LOH and chromosomal instability on a diploid background, and were relatively immune‐depleted. MFS and UPS showed extensive genomic overlap, with whole genome doubling occurring more frequently among the latter. The results support the idea that MFS and UPS tumours have largely overlapping genomic and transcriptomic features, with UPS tumours showing more aggressive behaviour and more complex genomes. Independently of the tumour type, clinically relevant subgroups were revealed by gene expression analysis, and the finding of multiple genomic subgroups strongly suggest the existence of subgroups of relevance to treatment stratification. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Construction of denser networks via functionalized aluminum oxide‐boron nitride hybrid fillers: Towards improved thermal conductivity of polycarbonate composites
Authors: Feng Fang , Luo Yongbiao , Yang Ruyi , Zhao Zhiheng 
Published: September 2024

AbstractWith the gradual acceleration of development in the modern electronics, there is a higher demand for insulating polymer composites with high thermal conductivity. Herein, the functionalized fillers were fabricated through first deposition of polydopamine (PDA) on boron nitride (BN) plates and then covalent modification of BN‐PDA and aluminum oxide (Al2O3) by γ‐aminopropyltriethoxysilane (APTES), respectively. Hybridized filler‐filled polycarbonate (PC) composites were prepared by partially substituting Al2O3 for BN plates with constant filler content. The PC composite filled with 9 wt% Al2O3 and 21 wt% BN (PCA3B7) achieved a thermal conductivity of 0.734 W mk−1, which is 217% and 21% higher than that of pure PC (0.231 W mk−1) and PCB (0.605 W mk−1), respectively. Besides, the PC composites exhibit excellent electrical insulation properties (1013 Ω cm), relatively good mechanical properties, and enhanced thermal stability. This PC composite, characterized by its superior comprehensive performance, holds significant promise as a thermal management material in electrical and electronic device applications.Highlights
Functionalized fillers were fabricated via covalent and non‐covalent methods.
The appropriate proportion of hybridized fillers showed synergistic effects.
The composite's thermal conductivity was 217% higher than pure PC.
The composite exhibited desirable electrical insulating characteristics and thermal stability.
The composite could act as a thermal management material.