bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-Spirit Peoples’ experiences accessing and receiving care from community pharmacies
Authors: Pirlot Marissa , Swidrovich Jaris 
Published: September 2024

Background: Two-Spirit Peoples face unique challenges in accessing and receiving health care in Canada due to health services, including community pharmacy services, being built on hetero- and cis-normative models that impede appropriate care for this group. Currently, there is limited published information on Two-Spirit Peoples’ experiences accessing and receiving care in community pharmacy settings. Methods: To address the lack of published information, 21 Two-Spirit individuals shared their experiences in a focus group setting. Four different focus groups were held across Canada, including 1 in Saskatoon, Vancouver, Edmonton, and Toronto. Informed by Indigenous methodologies, data were recorded via audio recording and notetaking, and the audio was transcribed and then analyzed for themes using the Voice-Centred Relational Method. Results: Three major structural systems that affect the experiences of Two-Spirit Peoples in community pharmacies were identified: 1) white supremacy, 2) capitalism, and 3) heteronormativity. These 3 systemic issues presented themselves via racism, homophobia, transphobia, pharmacists’ lack of knowledge about Two-Spirit individuals and their health and lack of time spent educating or building relationships with Two-Spirit Peoples. Participants provided suggestions for how community pharmacists can better serve the Two-Spirit community, such as using inclusive language, adding pronouns and preferred names to patient files, increasing knowledge about Two-Spirit health and advocating for Two-Spirit Peoples. Discussion: The results suggest that dismantling current structures and ideologies in community pharmacy and society are required to overcome the identified issues. Conclusion: Two-Spirit Peoples face barriers when it comes to accessing and receiving care in community pharmacies, resulting in many Two-Spirit individuals avoiding health care to save themselves from unsafe and uncomfortable interactions. Pre- and postlicensure pharmacy education about Two-Spirit Peoples is required to improve Two-Spirit Peoples’ experiences accessing and receiving care in community pharmacies.
Ultrasound-guided bilateral anterior quadratus lumborum block at the lateral supra-arcuate ligament in patients undergoing laparoscopic radical gastrectomy: A randomised controlled study
Authors: Lin Liangqing , Yu Yaohua , Ke Pinhui , Liu Lili , Wu Qinghua , Lin Qingshui 
Published: September 2024

Objective: Ultrasound-guided bilateral anterior quadratus lumborum block at the lateral supra-arcuate ligament has recently been proposed as an effective analgesia for abdominal surgery. To test the hypothesis that this novel technique was a viable alternative approach of conventional thoracic epidural analgesia for laparoscopic radical gastrectomy. Methods: Three hundred patients scheduled for laparoscopic radical gastrectomy were randomised 1:1 into the anterior quadratus lumborum block group: receiving the novel regional analgesia, and the thoracic epidural analgesia group: receiving thoracic epidural anaesthesia. The primary endpoint was intraoperative consumption of propofol and remifentanil. Intention-to-treat analysis was performed for all variables. Results: At five and ten minutes after block, anterior quadratus lumborum block group achieved more dermatomes coverage of the sensory block with both p < 0.001. Intraoperative consumption of propofol and remifentanil was comparable between two groups (1116.21 ± 199.76 versus 1166.45 ± 125.31µg, p = 0.245 and remifentanil 1.83 ± 0.41 versus 1.81 ± 0.37ng, p = 0.988). However, anterior quadratus lumborum block group was associated with less intraoperative consumption of norepinephrine and atropine, shorter time to urinary catheter removal and out-of-bed activity than the thoracic epidural anaesthesia group. No significant difference in extubation time, pain scores at rest and exercising at all time points following surgery was observed between the two groups. Conclusions: Compared with conventional thoracic epidural anaesthesia, the novel technique was an equivalent effective component of multimodal analgesic protocol for laparoscopic radical gastrectomy. There were some advantages, including shorter procedure time, more reliable dermatomal coverage, shorter duration of urinary catheterisation and earlier time of out-of-bed activity to enhance recovery after surgery. Trial registration: The study was registered in the Chinese Clinical Trial Registry on 2 November 2022 (ChiCTR2200065325).
Safety and efficacy of the Tao facemask for positive pressure ventilation in morbidly obese patients
Authors: Brewbaker Carey L , Wilson Phillip R , McSwain Julie R , Tobin Catherine D , Bridges Kathryn H , Roberts Laura L , Wilson Dulaney A , Skorke Christopher A , Brown Tod A 
Published: September 2024

Purpose: Positive-pressure mask ventilation is an essential skill for individuals providing basic and advanced airway interventions in a variety of clinical settings. The C-E grip technique is most commonly used with standard facemasks to provide an effective seal that allows for positive pressure ventilation. The Tao mask is a novel facemask that utilises an ergonomic grip by using downwards pressure of the palm of the hand accompanied by midline jaw lift. Specifically, the technique to create a seal involves downwards pressure of the palm centred on the mask accompanied by a jaw lift with four fingers centred under the mandible. A previous comparison between the Tao and standard masks revealed superior performance across a cross-section of average patients. The purpose of this study was to evaluate the safety and effectiveness of the Tao mask compared to the standard mask in a subset of patients with morbid obesity as defined by a body mass index (BMI) greater than or equal to 40 kg/m2. Methods: This prospective crossover trial included 156 patients aged ⩾18 years at the Medical University of South Carolina who were scheduled for elective surgery under general endotracheal anaesthesia with a BMI of ⩾40 kg/m2 at the time of surgery. After the induction of general anaesthesia, but prior to the administration of a neuromuscular blocking drug (NMBD), each patient was ventilated with both the standard and Tao masks, and effectiveness was measured using both the Han and Warters scales. The process was repeated after the administration of an NMBD. Results: Data were collected and analysed from 153 individuals. The mean BMI was 50.7 ± 9.3 kg/m2. The Tao mask ventilation scores were significantly lower (more effective) than the standard mask scores on both the Han and Warters Scales before pre-NMBD ( p = 0.0002 and p < 0.001, respectively) and after post-NMBD ( p = 0.002 and p < 0.001, respectively). On the Warters Scale, it was significantly easier to ventilate with the Tao Mask pre-NMBD ( p = 0.0001). On the Han Scale, the Tao mask was significantly easier than the standard mask post-NMBD ( p = 0.03). With regard to mask sequence, the mean Warters scores were lower for the Tao mask pre-NMBD only when the standard mask was used first ( p = 0.002). Similarly, the difference in the mean Warters scores post-NBMD was significant only when the standard mask was used first ( p = 0.02). Conclusion: The Tao mask demonstrated equivalent safety and superior effectiveness in ventilating morbidly obese surgical patients despite a trial design that favoured the standard mask owing to anaesthetist experience. The use of the Tao mask may be particularly beneficial in clinical situations involving inexperienced operators or in patients for whom mask ventilation is likely to be difficult. ClinicalTrials.gov registration number: NCT03473366
Unlocking the potential of deferoxamine: a systematic review on its efficacy and safety in alleviating myocardial ischemia-reperfusion injury in adult patients following cardiopulmonary bypass compared to standard care
Authors: Lamichhane Aashish , Sharma Sadish , Bastola Bishwas , Chhusyabaga Bikesh , Shrestha Nabin , Poudel Prajwal 
Published: September 2024

Background: Reperfusion injury, characterized by oxidative stress and inflammation, poses a significant challenge in cardiac surgery with cardiopulmonary bypass (CPB). Deferoxamine, an iron-chelating compound, has shown promise in mitigating reperfusion injury by inhibiting iron-dependent lipid peroxidation and reactive oxygen species (ROS) production. Objectives: The objective of our study was to analyze and evaluate both the efficacy and safety of a new and promising intervention, that is, deferoxamine for ischemia-reperfusion injury (I/R). Design: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines are used to perform the study. Data sources and methods: We conducted a systematic review following PRISMA guidelines to assess the efficacy and safety of deferoxamine in reducing I/R injury following CPB. A comprehensive search of electronic databases, namely, PubMed, Scopus, and Embase, yielded relevant studies published until August 18, 2023. Included studies evaluated ROS production, lipid peroxidation, cardiac performance, and morbidity outcomes. Results: (a) ROS production: Multiple studies demonstrated a statistically significant decrease in ROS production in patients treated with deferoxamine, highlighting its potential to reduce oxidative stress. (b) Lipid peroxidation: Deferoxamine was associated with decreased lipid peroxidation levels, indicating its ability to protect cardiac tissue from oxidative damage during CPB. (c) Cardiac performance: Some studies reported improvements in left ventricular ejection fraction and wall motion score index with deferoxamine. Conclusion: Our review shows that deferoxamine is an efficacious and safe drug that can be used to prevent myocardial I/R injury following CPB. It also highlights the need for trials on a larger scale to develop potential strategies and guidelines on the use of deferoxamine for I/R injury.
Preliminary results on temporal evolution and clinical implications of atherosclerotic plaque in branch atheromatous disease after statin treatment
Authors: Huang Yen-Chu , Tsai Yuan-Hsiung , Lin Leng-Chieh , Weng Hsu-Huei , Lee Jiann-Der , Yang Jen-Tsung 
Published: September 2024

Background: Branch atheromatous disease (BAD) is a primary cause of early neurological deterioration (END) in penetrating artery occlusion, leading to poor functional outcomes. While it has been proposed to classify BAD under large artery atherosclerosis, uncertainty exists regarding the optimal treatment strategy, including cholesterol-lowering targets. Objectives: We aimed to assess the clinical implications and temporal changes of atherosclerotic plaques before and after high-intensity statin treatment. Design: This is a high-resolution vessel-wall imaging sub-analysis of the trial of Statin and Dual Antiplatelet Therapy in Preventing Early Neurological Deterioration in Branch Atheromatous Disease (SATBRAD). Methods: In this prospective, single-group cohort study, participants in the treatment arm of the SATBRAD trial received early dual antiplatelet therapy and high-intensity statin treatment. The majority of these participants subsequently underwent high-resolution vessel-wall magnetic resonance imaging (MRI). Those with atheromatous plaques in the parent artery continued high-intensity statin treatment for 6 months, followed by a repeat MRI to monitor plaque changes. Results: There were 57 patients who underwent vessel-wall imaging and 24 exhibited contrast-enhanced plaques. Patients with contrast-enhanced plaques showed higher rates of END (29.2% vs 6.1%, p = 0.027), perfusion defects (62.5% vs 24.2%, p = 0.004), and lower rates of good outcomes at 3 months (50.0% vs 81.8%, p = 0.011). After adjusting for confounding factors, contrast-enhanced plaque had a negative impact on achieving a good outcome at 3 months (adjusted odds ratio = 0.04; 95% confidence interval = <0.01–0.60). Following high-intensity statin treatment in 36 patients, there was a notable reduction in stenosis (33.7% vs 29.3%, p = 0.005) and contrast-enhanced plaque volume (16.3 vs 11.6 mm3, p = 0.015). Conclusion: The study highlighted the association between contrast-enhanced atherosclerotic plaques, END, and poor functional outcomes, with high-intensity treatment leading to plaque volume reduction. These results underscore the shared pathology between BAD and intracranial atherosclerosis, emphasizing the necessity for further research and tailored treatment strategies for BAD. Trial registration: ClinicalTrials.gov; Identifier: NCT04824911 ( https://clinicaltrials.gov/study/NCT04824911 ).
The Influence of Weather Conditions on the Immortelle Volatile Constituents from Essential oil and Hydrosol with a Focus on Italidiones and Its Molecular Docking Anti-Inflammatory Potential
Authors: Aćimović Milica , Stanković Jeremić Jovana , Todosijević Marina , Cvetković Mirjana , Lončar Biljana , Vukić Vladimir , Erceg Tamara , Pezo Lato , Zheljazkov Valtcho D. 
Published: September 2024

Objectives Immortelle has garnered global attention for its cosmetic, medicinal, and culinary applications worldwide. Apart from neryl acetate, α-pinene and γ-curcumene as the most important components for the estimation of the essential oil quality, in recent years a group of β-diketones, known as italidiones, appear as significant quality parameters. However, it is unknown how weather conditions (temperature and precipitation) influence their accumulation in essential oil and hydrosol, nor their anti-inflammatory potential. Methods This study investigates the chemical composition of immortelle essential oil and hydrosol over three successive years (2019/20, 2020/21, and 2021/22), by GC-FID and GC-MS analysis. In silico molecular docking model with Vascular Adhesion Protein-1 (VAP-1) was used for the simulation of the anti-inflammatory potential of italidiones, as well as other β-diketones present in immortelle essential oil and hydrosol. Results During the three-year trial, it was established that essential oil compounds such as α-pinene, neryl acetate, and italicene were positively correlated with temperature and negatively correlated with precipitation, as well as β-diketones and total italidiones. Moreover, trans-caryophyllene, γ-curcumene, and ar-curcumene were in negative correlation with temperature, and a slight positive correlation with precipitation. On the other side, in the hydrosol the content of both total β-diketones and total italidiones was strongly negatively correlated with temperatures, and positively correlated with precipitation, which was the opposite of essential oil. Additionally, findings indicated that italidiones could bind the human VAP-1 protein in the vicinity of the topiquinone and block its function. Conclusion Weather conditions affect variations in the accumulation of volatile compounds in essential oil and hydrosol, which in some cases can affect changes in olfactory characteristics, as well as criteria prescribed by standards, and even changes in biological activities. These results indicate that italidiones, as well as other β-diketones present in immortelle, may be responsible for its anti-inflammatory activity.
Pilates Dosage in Rehabilitation of Patients With Musculoskeletal Conditions: A Scoping Review
Authors: Sivrika Aikaterini Pantelis , Kypraios Georgios , Lamnisos Demetris , Georgoudis George , Stasinopoulos Dimitrios 
Published: September 2024

Context: Pilates exercise is commonly used in the rehabilitation of individuals with musculoskeletal conditions, but dosing parameters for optimal outcomes are unclear. Large variations exist in Pilates-based protocols, and research related to specific dosing is sparse. Objective: To identify optimal dose parameters of Pilates exercise when applied to the rehabilitation of musculoskeletal conditions. Data Sources: English-language articles published up to February 2023, in the PubMed, Scopus, Science Direct, and Pedro databases. Study Selection: Articles where patients 20–60 years old with musculoskeletal conditions received a Pilates-based exercise intervention and reported quantification of treatment dose. A total of 72 full-text articles were assessed, with 14 meeting inclusion criteria. Study Design: Scoping review. Data Extraction: Two investigators (A.P.S., G.K.) independently identified all proposed Pilates-based protocols and outcome measures from the included studies. Results: From the 1667 references initially found in 4 databases, 14 studies were included of which 13 were randomized controlled trials or quasi-experimental (612 patients) and 1 was a Cochrane review (19,642 patients). Eight studies were of high methodological quality. The most frequent musculoskeletal condition examined was chronic low back pain. Pilates dosage regarding total intervention duration ranged from 6 to 16 weeks, but the most frequent duration reported was 8 weeks and 2 to 3 sessions per week with sessions lasting 50 to 60 minutes. Conclusion: This review suggests that there are clinically relevant Pilates dosing parameters that result in improved outcomes for patients with musculoskeletal disorders.
Enhancing structural protection of reinforced concrete structures against high dynamic loads using post-installed UHPFRC/UHPFRSC
Authors: Strotmann Andre , Jungwirth Jörg , Zohrabyan Vahan , Braml Thomas 
Published: September 2024

Recently there has been an observed change in security policy across the globe which implies that humanity must prepare for hybrid and asymmetric acts of war. This security situation will result in spontaneous attacks from non-military groups. The threats include ballistic attacks from commercially available weapons, detonation of explosives, and impact of vehicles. These attacks are focused on critical infrastructures. Reinforced concrete (RC) elements with ballistic and explosion protection are of huge relevance. This requires new concepts and innovative solutions for the protection of new buildings and/or for the strengthening of existing structures. In this paper a method for the increase of structural safety is shown using Ultra-High Performance Fiber Reinforced Concrete (UHPFRC) or sprayed UHPFRC, so called UHPFRSC, as a surface layer for reinforced concrete structures. The UHPFRC/UHPFRSC is applied in thin layers of 30 - 80 mm on the protection side. The interaction of the two different cementitious materials results in increased resistance to high dynamic loads. The traditional reinforced concrete on the impact side absorbs a major fraction of the energy of impact. On the back side (protection side), tensile forces are generated by the impact, which can excellently be handled by the UHPFRC/UHPFRSC. For proof of concept of the hybrid strengthening method, tests were carried out on UHPFRC - RC composite elements. In the test campaign, ballistic tests were performed using test specimens with dimensions of 500 × 500 mm. The layer thicknesses were 120 mm reinforced concrete and 40 mm UHPFRC. Additional steel rebars in the UHPFRC layer were applied for half of the specimens. The investigation demonstrated the effectiveness of the strengthening method, showing high resistance to high-dynamic loads. This behavior is attributed to the absorption and transfer of tensile stresses by the UHPFRC, that reduces penetration depth and damage, ensuring remaining load-bearing capacity after gunfire.
Numerical study of composite structures behavior under ballistic impacts
Authors: Nanema Billy Lorcendy Terrence , Mejri Mohamed , Ben Salah Nizar 
Published: September 2024

The aim of this paper is to introduce a finite element study of the behavior of composite plates subjected to ballistic impacts. The work studies different configurations of laminated composite structures, with and without reinforcements, subjected to high-speed projectile impacts (400-1000 m/s). The investigation focuses on the response of different composite materials' stacking sequences, as well as the impact of epoxy carbon reinforced with carbon nanotubes and the behavior of hybrid sandwich structures made of Kevlar epoxy and glass epoxy. The purpose is to develop a strategy of composite material damage modelling, identify the effects of multi material hybridization, and the influence of reinforcement by carbon nanotubes, on the structures' resistance to ballistic impacts. Numerical simulation provides a detailed description of plate damage. Results show that composite plates with 2% carbon nanotubes (CNT) displays a better impact energy absorption compared to 1% CNT and plates without CNT. The study also revealed the hybridization sequences offering the greatest energy absorption.
Impact of different doses of esketamine on the incidence of hypotension in propofol-based sedation for colonoscopy: a randomized controlled trial
Authors: Fu Mengyue , Sheng Bo , Liu Rui , Li Yongjie , Chen Guizhen , Chen Hai , Chen Xuehan , Duan Guangyou , Huang He , Chen Jie , Chen Yuanjing 
Published: September 2024

Background: Hypovolemia is common in colonoscopy due to fasting and bowel preparation, and propofol itself can reduce systemic vascular resistance, resulting in relative hypovolemia. Therefore, hypotension is not a rare event during propofol-based sedation for colonoscopy. Objectives: Our objective was to explore the efficacy of esketamine as a sedative adjuvant in reducing the incidence of hypotension during colonoscopy. Design: This was a prospective randomized trial. The trial was registered with the Chinese Clinical Trial Registry (ID: ChiCTR 2100047032). Methods: We included 100 eligible patients who planned to receive a colonoscopy and randomly divided them into 4 groups with 25 patients in each group, which were propofol 2 mg/kg (Group P), propofol 1 mg/kg with esketamine 0.2 mg/kg (Group E1), propofol 1 mg/kg with esketamine 0.3 mg/kg (Group E2), and propofol 1 mg/kg with esketamine 0.4 mg/kg (Group E3). The hemodynamic and respiratory parameters were documented at various times during the procedure, including the patient’s entry into the endoscopic room (T0), the induction of sedation (T1), the insertion of the colonoscope (T2), the removal of the colonoscope (T3), and the awakening of the patient (T4). The primary outcome was the incidence of hypotension. Secondary outcomes were cardiovascular side effects other than hypotension, incidence of hypoxia, cumulative changes in cardiovascular and respiratory parameters, total propofol dosage, anesthesia recovery time, and satisfactory levels of both patients and endoscopists. Results: The incidence of hypotension in Group E1 (16%), Group E2 (16%), and Group E3 (12%) was significantly lower than in Group P (60%), with p values 0.003, 0.003, and <0.001 respectively. The cumulative changes in diastolic blood pressure and mean arterial pressure in Groups E1, E2, and E3 were significantly higher than in Group P ( p = 0.024, p < 0.001, p = 0.006, respectively). Cumulative changes in systolic blood pressure in Group E3 were significantly higher than those in Group P ( p = 0.012). The respiratory-related parameters were not statistically significant. Conclusions: This study showed that the application of 0.4 mg/kg esketamine in propofol-based sedation reduced the incidence of hypotension during colonoscopy while providing satisfactory sedation.