bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco‐2 cells
Authors: Gigli Stefano , Seguella Luisa , Pesce Marcella , Bruzzese Eugenia , D’Alessandro Alessandra , Cuomo Rosario , Steardo Luca , Sarnelli Giovanni , Esposito Giuseppe 
Published: March 2017

BackgroundClostridium difficile toxin A is responsible for colonic damage observed in infected patients. Drugs able to restore Clostridium difficile toxin A‐induced toxicity have the potential to improve the recovery of infected patients. Cannabidiol is a non‐psychotropic component of Cannabis sativa, which has been demonstrated to protect enterocytes against chemical and/or inflammatory damage and to restore intestinal mucosa integrity.ObjectiveThe purpose of this study was to evaluate (a) the anti‐apoptotic effect and (b) the mechanisms by which cannabidiol protects mucosal integrity in Caco‐2 cells exposed to Clostridium difficile toxin A.MethodsCaco‐2 cells were exposed to Clostridium difficile toxin A (30 ng/ml), with or without cannabidiol (10−7 –10−9  M), in the presence of the specific antagonist AM251 (10−7  M). Cytotoxicity assay, transepithelial electrical resistence measurements, immunofluorescence analysis and immunoblot analysis were performed in the different experimental conditions.ResultsClostridium difficile toxin A significantly decreased Caco‐2 cells’ viability and reduced transepithelial electrical resistence values and RhoA guanosine triphosphate (GTP), bax, zonula occludens‐1 and occludin protein expression, respectively. All these effects were significantly and concentration‐dependently inhibited by cannabidiol, whose effects were completely abolished in the presence of the cannabinoid receptor type 1 (CB1) antagonist, AM251.ConclusionsCannabidiol improved Clostridium difficile toxin A‐induced damage in Caco‐2 cells, by inhibiting the apoptotic process and restoring the intestinal barrier integrity, through the involvement of the CB1 receptor.
The crystal structure of the new mineral dyrnaesite-(La),Na8CeIVREE2(PO4)6
Authors: Balić-Žunić Tonči 
Published: March 2017

AbstractDyrnaesite-(La), Na7.89(Ce0.94Ca0.06)∑1.00(La1.14Ce0.40Pr0.10Nd0.24Ca0.12)∑2.00(PO4)6is orthorhombic,Pnma,a= 18.4662(7),b= 16.0106(5),c= 7.0274(2) Å,V= 2077.7(1) Å3,Z= 4. The crystal structure is related to the group of Na3REE(XO4)2compounds (with X = P, V, As), based on the aphthitalite/glaserite structural type. Dyrnaesite is distinct in having ordered Na vacancies, and a rare-earth element (REE) site occupied preferentially by Ce4+. This also distinguishes it from closely related vitusite-(Ce) [Na3REE(PO4)2]. The relation of their unit cells is:ad=bv,bd= 3av,cd= 1/2cv. The distinct Ce4+site in dyrnaesite-(La) has smaller coordination with shorter bond lengths than the otherREEsite in the same structure or theREEsites in vitusite-(Ce). It is adjacent to the predominately vacant Na site, which in its turn has the largest coordination of all Na sites in the structure.REEsites, or Na sites in a [010] row (similar to [100] in vitusite(Ce)) assume two types of coordinations with and without mirror symmetry and two different configurations of surrounding PO4tetrahedra. This summarizes the topological difference to vitusite-(Ce) where the corresponding coordinations are similar in the same row and intermediate in character to the two types in dyrnaesite-(La).
Women-Identified Women
Authors: Heaney Emma 
Published: March 2017

Abstract
This essay argues that retrieval of the archive of trans women's engagement with women's liberation corrects a historical focus on the virulent trans misogyny that targeted trans women for exclusion from feminist milieus and projects beginning in 1973. This essay follows the arguments for trans exclusion into their contemporary iterations and proposes the archive of trans women's feminist work as a theoretical and political resource for countering trans misogyny.
Reading Trans Biology as a Feminist Sociologist
Authors: Lane Riki 
Published: March 2017

Abstract
Feminist analysis has often rejected ideas that biology influences gender development as inherently reactionary. However, some trans people have found personal and political utility in making the argument that they were “born this way.” This essay argues for an understanding of nature and culture that aims to supersede a division of bodies as authentic and real versus constructed and mutable—reappraising scientific understandings of sex and gender can overcome this false dichotomy. Recent biological and neurological research has shifted from linear determinism toward ideas of nonlinearity, contingency, self-organization, and open-endedness. Feminist and trans studies engagement with such research offers ways around theoretical impasses and can assist struggles for social and political change.
Radical Queen
Authors: Stryker Susan 
Published: March 2017

Abstract
Tommi Avicolli Mecca, born in Philadelphia in 1951, moved to San Francisco in 1991 and quickly established himself as a leading queer performance artist, playwright, and newspaper columnist as well as a leading housing rights and antigentrification activist. This interview is excerpted from an interview initially conducted by Susan Stryker, general coeditor of TSQ: Transgender Studies Quarterly, for the GLBT Historical Society on November 19, 1998, and edited in consultation with Mecca for publication in TSQ, to highlight content related to the interrelationships between feminism, drag culture, and gay liberation politics in Philadelphia in the 1970s. In what follows, Mecca discusses his early involvement with radical sexuality and gender politics with the Gay Liberation Front (GLF) at Temple University, his later involvement in the more assimilationist Gay Activist Alliance (GAA), the formation of the Radical Queens collective, and his alliance with the separatist lesbian feminist group DYKETACTICS.
Efficient Ranking and Selection in Parallel Computing Environments
Authors: Ni Eric C. , Ciocan Dragos F. , Henderson Shane G. , Hunter Susan R. 
Published: March 2017

The goal of ranking and selection (R&S) procedures is to identify the best stochastic system from among a finite set of competing alternatives. Such procedures require constructing estimates of each system’s performance, which can be obtained simultaneously by running multiple independent replications on a parallel computing platform. Nontrivial statistical and implementation issues arise when designing R&S procedures for a parallel computing environment. We propose several design principles for parallel R&S procedures that preserve statistical validity and maximize core utilization, especially when large numbers of alternatives or cores are involved. These principles are followed closely by our parallel Good Selection Procedure (GSP), which, under the assumption of normally distributed output, (i) guarantees to select a system in the indifference zone with high probability, (ii) in tests on up to 1,024 parallel cores runs efficiently, and (iii) in an example uses smaller sample sizes compared to existing parallel procedures, particularly for large problems (over 106 alternatives). In our computational study we discuss three methods for implementing GSP on parallel computers, namely the Message-Passing Interface (MPI), Hadoop MapReduce, and Spark, and show that Spark provides a good compromise between the efficiency of MPI and robustness to core failures. The e-companion is available at https://doi.org/10.1287/opre.2016.1577 .
The ideological challenge for the regional press; reappraising the community value of local newspapers
Authors: Matthews Rachel 
Published: March 2017

Abstract
Existing for the good the community has been an established claim to legitimacy for the English regional press since the nineteenth century. Expressed varying as a localized version of the fourth estate or ‘parish pump patriotism’, this article understands this notion as a discursive position which underwrites claims by the local newspaper to act as a watchdog on behalf of those readers it seeks to serve. As such it serves an ideological function and justifies the normative practices of the industry. However, interviews with newspaper workers suggest that while the good of the community remains a key professional value, increasingly they feel compromised in their ability to uphold it due to the economic environment in which they are operating. It concludes with the proposition that the political economy of the local newspaper needs to invest in real terms in the good of the community if its normative function is to be retained.
Moments of (aha!) walking and encounter: Fluid intersections with place
Authors: Burke Geraldine , Lasczik Cutcher Alexandra , Peterken Corinna , Potts Miriam 
Published: March 2017

Abstract
In contemporary art, research and art education, the concepts of walking and mapping in singular and collaborative encounters with place are established as a generative learning, creative and research event. In this iteration of walking and encounter, four arts academics sought to extend and engage the practice of itinerant drift, collaboratively and discretely, mapping manifestations and then responding with an artful riposte in relation to educational practice. Using the provocation of playfulness, the methodology was inspired by the concept of the dérive and stimulated by Dada, Surrealist and Fluxus legacies. This visual essay portrays the assemblage of walking and encounter at the Peninsula campus site at Monash University through visual poetics, which aims to arouse continuing dialogue around place, learning, encounter, chance and disruption.
Sustaining Huaco making in Perú: A decolonizing study with a native knowledge bearer
Authors: Alexander Amanda 
Published: March 2017

Abstract
This article investigates the extensive knowledge and experience of a traditional Peruvian huaco maker named Lorenzo Cabrera Abanto. Huaco is a pre-Columbian pottery form that western museums and literature identify as a portrait jar or vessel. Lorenzo is discussed as a living repository of ancient heritage and Andean art making for those unfamiliar with its expressions. Due to globalization and changing dynamics in Peruvian culture and economy, huaco making as an expression of Peruvian heritage is threatened. Examining huaco making and history through a decolonizing lens, Lorenzo’s life and work as a native knowledge bearer is considered in light of globalization, the demands of the capitalist markets, theoretical premises of critical pedagogues, and concerns of an art educator. Confronting cultural interactions and shifting global paradigms, the arts education field can productively draw on critical art pedagogy that is informed by diverse discourses and reveres Native wisdom and knowledge of living art forms such as those sustained by Lorenzo.
The Silver Voices: A possible model for senior singing
Authors: Balsnes Anne Haugland 
Published: March 2017

Abstract
Every Tuesday morning, 150 people from the age of 62 and above gather to sing in Kilden Performing Arts Centre, Kristiansand, Norway. A case study of this choir, The Silver Voices, was conducted. The aim of the study was to understand the practice and how an art institution can play a role in developing such an activity. As a point of departure the following questions were formulated: What is going on in the choir? Why and how is the activity organized? What is the meaning of the participation for the singers? The collection techniques utilized were participant observation, semi-structured interviews and document analysis. Perspectives from the fields of music education, community music and music and health will illuminate the analysis. The study shows that a musical activity such as The Silver Voices transcends distinctions between disciplinary fields.
Empire Cinema: Propaganda and censorship in colonial films during the Portuguese Estado Novo
Authors: Piçarra Maria do Carmo 
Published: March 2017

Abstract
Aiming to provide a critical analysis of the filmic memorial of Portuguese colonialism I consider two alternative ‘visions of cinema’: the official version presented in Estado Novo propaganda newsreels, and, in ‘reverse shot’, the disruptive gaze found in censored auteur fiction films – Faria de Almeida’s Catembe (1965), Lopes Barbosa’s Deixem-me ao Menos Subir às Palmeiras… (1972) and António de Sousa’s Esplendor Selvagem (1972). Portuguese colonies were seldom depicted on film, and only the ‘right kind’ of images – specifically those presented in propaganda newsreels – tended to be approved by the censorship committees. Faria de Almeida received government support to film everyday life in Mozambique’s capital, in 1964. After the first version of the film was censored – with 103 cuts, a Guinness world record – projection of Catembe was banned.1 In 1972, Barbosa made a film about abuses of power in colonial farms in Mozambique. The film was banned. Sousa recorded initiation rituals and rites of passage in different Angolan ethnic groups. The documentary was considered ‘anti-political’. Until conducting this research, the films remained deposited at the Portuguese Cinema Museum, largely unknown to audiences and researchers. What are the limitations of the history of cinema – and of the knowledge of the ‘imagined man’ – as long as the perspectives provided in such censored colonial films remain unanalysed?
Cronenberg’s debt to Kafka: An analysis of A Country Doctor (1917) and Videodrome (1983)
Authors: Moody Paul 
Published: March 2017

Abstract
David Cronenberg has often been regarded as a literary director, who draws on a well-versed knowledge of literature for his film projects. This is most evident in his adaptations of authors often thought to exert the greatest influence on his work, from Burroughs (Naked Lunch) to Ballard (Crash). Yet there is another author with an equally potent, if mostly unacknowledged, impact on Cronenberg’s output – Franz Kafka. Cronenberg has never directly adapted a Kafka story, yet elements of the ‘Kafkaesque’ permeate Cronenberg’s oeuvre, none more so than in his 1983 film, Videodrome. Drawing on Mark Browning’s work, I argue that the similarities between Videodrome and the short story A Country Doctor (1917) are so stark, that Cronenberg’s film should be considered as an adaptation of Kafka’s composition, and that further connections between the two artists become apparent in light of this association.
Music technology, composition teaching and employability skills
Authors: Otondo Felipe 
Published: March 2017

Abstract
This article explores the relationship between the creative skills taught as part of the music technology BA course at Lancaster University and the skills valued by graduates and employers in the creative industries. The study investigated ways of enhancing specific and generic employability skills intrinsic to music technology teaching while working in close collaboration with industry partners and Lancaster University graduates. A survey of students, graduates and industry experts showed that generic and discipline-based skills linked to music technology composition teaching, such as communication, planning and organizing and critical listening, are highly valued by both recruiting professionals and students. These results are in line with findings from an earlier project that showed the importance of non-disciplinary knowledge shared among students from different backgrounds for the design and implementation of successful interdisciplinary collaborations. Future developments of the project will investigate ways of enhancing generic and specific employability skills within interdisciplinary learning environments for art and science students.
Remixing dub reggae in the music classroom: A practice-based case study on the educational value of music production for listening skills and stylistic analysis
Authors: Herbst Jan-Peter 
Published: March 2017

Abstract
This article examines learning opportunities of music production tasks by an exemplary unit on dub reggae following an action research approach. It addresses the educational areas of sound design, musical knowledge, analysis and listening skills, taking the sound of dub reggae as starting point for learner-centred activity. The main premise is to advocate music production technology as an effective tool for music learning allowing students to experience techniques of music production first hand, vividly illustrating creative approaches of remote musical cultures, their successive influence on popular music, and aesthetic experiences special to technologically created sound. The overall goal is to facilitate a higher awareness and a more detailed understanding of produced sound, and practical competences of integrating technological sound into musical action. The study took place within two vocational college courses for social and health (N = 10; 7 women, 3 men; average age 21 years) and art and design (N = 9; 5 women, 4 men; average age 18.3 years), and aimed to investigate the methodical practicability and the success of the suggested educational approach. It provides preliminary insights along with recommendations for improvements and further applications.
Maschine-itivity: How I found my creativity using a digital sampling device to compose music
Authors: Kladder Jonathan 
Published: March 2017

Abstract
The ubiquity of digital music technology has prompted researchers and scholars to examine how music educators might support music learning that encourages creativity through the use of these mediums. Infusing technology into current curricular offerings offers one avenue in fostering a diversity of music learning experiences for students when teachers are interested in developing creativity in their students. Research examining current practising teachers and their experiences with digital sampling and beat making technology is limited. The purpose of this research was to offer my experiences learning, writing and sharing music using a sampling and beat-making device called the Maschine. This auto-ethnography uses Sawyer’s eight stages of the creative process as the theoretical framework to guide analysis of my creativity. The aims of this research were to: (1) reflect on the creative process involved in making music on a digital sampling and beat-making device; (2) provide a contextual understanding of my challenges and successes along the way; and (3) suggest implications for both current and future music teachers interested in learning to use this type of technology in their music teaching to provide contemporary music making experiences for their students. Results suggest that vernacular and informal music learning strategies were common over the 14-week semester, as YouTube tutorials supported my learning. My creativity occurred in small incremental steps and yielded three completed compositions at the culmination of the project. A conceptual model of the creative process is proposed, outlining the non-linearity of my creative process. Implications for music education are offered in conclusion.
Drawing the pathetic parent creature: Aline Kominsky Crumb in conversation with Sarah Lightman
Authors: Lightman Sarah 
Published: March 2017

Abstract
In this abridged and edited transcription of ‘“Arnie’s Air Conditioner” and other fond memories: Aline Crumb in conversation with Sarah Lightman’, held on 15 April 2016 at The House of Illustration, Kominsky Crumb talks through her role in the history of autobiographical comics, and discusses comics that reflect on her childhood experiences. She also describes how she deliberately approached parenting her daughter, Sophie, differently and how this is reflected in her works.
Drugs, earthquakes and high-school girls: An interview with Reiko Momochi
Authors: Rabone Emily 
Published: March 2017

Abstract
This is an interview with Reiko Momochi, a Japanese shojo manga artist best known for producing the Confidential Confessions (2003) series. The interview was carried out with the aim to gain an insight into the manga industry in Japan, with a particular focus on the matter of gender.
Urine specific gravity as a diagnostic tool for dehydration in children
Authors: Purwanto Kalis Joko , Juffrie Mohammad , Ismail Djauhar 
Published: March 2017

Background Using clinical judgment to diagnose dehydration can be highly subjective. To diagnose dehydration, it would be ideal to have an accurate, inexpensive, objective and easy-to-perform diagnostic tool. In cases of dehydration, plasma osmolality rises, causing an increase in antidiuretic hormone (ADH) secretion. The increased ADH reduces urine production and increases urine osmolality. Previous studies have show that urine osmolality correlates well to urine specific gravity. We investigated if urine specific gravity can be a reliable and objective detennination of dehydration status.Objective To assess the accuracy of using urine specific gravity as a diagnostic tool to determine dehydration status of children with diarrhea.Methods We conducted the study in the pediatric ward of Sardjito Hospital from September 2009 to December 2009. Using a refractometer we measured urine specific gravity from patients with diarrhea. This measurement was then compared to a standard of acute body weight loss, with dehydration defined as weight loss of 5% or more. The cut-off value for defining dehydration using specific gravity measurements was detennined by a receiver-operator curve (ROC).Results Out of 61 pediatric patients who were recruited in this study, 18 (30%) had dehydration as defined by a body weight loss of 5% or more. Based on the ROC, we determined the cut off value for urine specific gravity to be 1.022. Using this value, urine specific gravity was 72% sensitive (95% CI 52 to 93), and 84% specific (95% CI 73 to 95) in determining dehydration status.Conclusion Urine specific gravity is less accurate than clinical judgment in determining dehydration status in children with diarrhea.
Risk factors for low bone density in pediatric nephrotic syndrome
Authors: Lisa Corina , Julia Madarina , Kusuma Pungky A. , Sadjimin Tonny 
Published: March 2017

Background Disturbances in bone mineral metabolism and side effects of corticosteroid treatment may cause decreased bone density in patients v.ith nephrotic syndrome (NS).Objectives To compare the prevalence oflow bone mineral density (BMD) in children with and 'Without NS and to assess the effect of corticosteroid treatment on bone density in NS patients. Methods We conducted a retrospective, cohort study in children aged 5-18 years diagnosed 'With NS for more than 2 months prior to data collection, and in children v.ithout NS as a control. BMD was assessed on calcaneal bone wlith ultrasound bone densitometry. Serum calcium, albumin, creatinine and phosphate levels were also assessed.Results The prevalence of low BMD was significantly higher in NS patients than non􀁂NS subjects, 73.3% (22 in 30) vs. 33% (11 in 33), respectively. The prevalence ratio was 6.3 (95% CI 2.1 to 18.9). NS patients had lower serum calcium levels, With mean difference of -0.17 (95% CI -0.27 to -0.07 mMollL), P<0.009, and lower serum albumin, with mean difference of -0.88 (95% CI -1.27 to -0.49 gIL); P<O.OO 1, than non􀁂NS subjects. After adjusting for other risk factors, we found NS to be an independent risk factor for low BMD. Steroid-resistant and steroid-dependent patients had lower BMD than steroid-sensitive subjects (P=0.02). There was also a significant correlation between the onset of corticosteroid treatment and BMD (r=O.3; P=0.02).Conclusions NS patients had higher risk for low BMD compared to normal subjects. Response to steroid treatment influences the severity of impaired bone density.