bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Repetitive Control and Disturbance Rejection Based on Two‐Dimensional Model and Equivalent‐Input‐Disturbance Approach
Authors: Yu Pan , Wu Min , She Jinhua , Lei Qi 
Published: February 2016

AbstractA new configuration of a modified repetitive‐control system has been devised for a class of strictly proper plants that suppresses exogenous disturbances and uncertainties in the dynamics of the plant. It extends the applicability of the control system. The system consists of four parts: a two‐dimensional augmented model of the plant, which takes into account the difference in characteristics between continuous control and discrete learning in repetitive control; an equivalent‐input‐disturbance estimator; a state observer; and a state‐feedback controller. A robust‐stability condition expressed in terms of a linear matrix equality is used to determine the gains of the observer and the controller. Finally, a comparison of our method with repetitive control based on linear active disturbance rejection control (LADRC) shows how effective our method is and that it is superior to LADRC‐based repetitive control.
Fahrdynamische Verträglichkeit
Authors: Franz Stefan 
Published: February 2016

AbstractEin Brückenstatiker gerät leicht unter Druck, wenn der Bauherr die nach ZTV‐ING geforderte Bewertung der “fahrdynamischen Verträglichkeit” der gewählten Ausgleichsgradiente einfordert. In dem schmalen Korridor einer zulässigen Mindest‐ bzw. Maximaldicke der Schutzschicht müssen herstellungsbedingte Bauungenauigkeiten der Fahrbahnplatte ausgeglichen werden. Das Bestreben seitens der ausführenden Baufirma ist, dass möglichst keine zeit‐ und kostenintensiven Fräs‐ bzw. Spachtelarbeiten mit Betonersatzsystemen erforderlich werden. Nicht selten wird dann die für das Ergebnis so bedeutende Forderung nach fahrdynamischer Verträglichkeit aus den Augen verloren, zumal hierfür keine Grenzwerte oder Kriterien angegeben sind.In diesem Beitrag wird ein einfaches Berechnungsverfahren vorgestellt, das eine objektive Bewertung der fahrdynamischen Qualität der gewählten Ausgleichsgradiente zulässt. Die hierzu erforderlichen Grenzwerte und Berechnungsparameter werden zur Verwendung empfohlen. Es sind ferner Faustformeln angegeben, die eine erste Risikobewertung ermöglichen und ggf. genauere Untersuchungen entbehrlich machen.Driving dynamics compatibilityThe evaluation of "driving dynamics compatibility” of a compensating altitude profile according to ZTV‐ING is a particular challenge with respect to the verification process. The minimum and maximum thickness of the protection layer of the pavement is strictly regulated. However, this layer must compensate production‐related construction tolerances of the deck. The construction company wants to avoid time‐ and cost‐intensive milling and filling work with concrete replacement systems. Therefore, the contractors and the clients lose sight of the required driving dynamics comparability. On the other hand, there are no limitations or criteria specified for this purpose. In this paper, a simple calculation method is presented which allows an objective evaluation of driving dynamics quality of the chosen compensating altitude profile. Demanded limits and calculation parameters are recommended for use. Furthermore, empirical formulas are specified which allow an initial risk assessment and more detailed investigations can possibly be avoided.
Design‐und‐Build‐Projekt: Planung und Bau einer Messwarte mit Laborgebäude
Authors: Dürr André , Brendel Christiane , Borsutzky Robert , Giesa Ingo 
Published: February 2016

AbstractDesign und Build‐Vergaben sind für Bauherren insbesondere dann interessant, wenn kurze Ausführungsfristen für die Fertigstellung und Inbetriebnahme von Gebäuden realisiert werden müssen und die Bauvorhaben einen erhöhten Komplexitätsgrad aufweisen. Unter diesen Voraussetzungen entscheiden sich Bauherren des Öfteren dafür, getrennte Planungs‐, Vergabe‐ und Ausführungsabläufe mit den erforderlichen Schnittstellenkoordinationen aus Effizienzgründen in einem Paket zu vergeben. Beim Neubau einer dreistöckigen Messwarte mit angeschlossenen Laborgebäude für eine neue Produktionsanlage von Toluoldiisocyanat (TDI) am Standort Ludwigshafen hat die BASF SE daher die HOCHTIEF Building GmbH mit einem Design und Build‐Projekt beauftragt. Die Planung wurde dabei federführend durch die Abteilung Consult IKS Energy der HOCHTIEF Engineering GmbH am Standort Frankfurt durchgeführt. Die Planung umfasste dabei teilweise die Entwurfs‐ und Genehmigungsplanung sowie die vollständige Ausführungsplanung für alle bautechnisch erforderlichen Planungsgewerke, angefangen von der Objektplanung über die Tragwerksplanung und Fassadenplanung bis hin zu bauphysikalischen Nachweisen und der TGA‐ und Laborplanung. Darüber hinaus musste der auf einer Pfahlgründung in Massivbauweise errichtete Gebäudekomplex druckwellenfest ausgelegt werden. Bei der Gebäudeauslegung und Planung waren für den Notfall zusätzlich Anforderungen zur Gasdichtheit inklusive einer gebäudeinternen Atemluftversorgung zu berücksichtigen.Design‐and‐Build Project: Design and construction of a control room with laboratoryDesign and build contracts are of particular interest for clients if tight schedule requirements for the completion and commissioning of buildings have to be considered and the projects have a high level of complexity. With these preconditions clients rather decide to award separate planning, procurement and construction processes with all necessary interface coordination to one contractor for reasons of efficiency. BASF SE has awarded a design and build contract to HOCHTIEF Building GmbH for a three‐storey control room building with laboratory for a new production plant of toluoldiisocyanat (TDI) at the main BASF site in Ludwighafen, Germany. The planning was performed by the department Consult IKS Energy of the HOCHTIEF Engineering GmbH in Frankfurt. The scope of planning included partially the design engineering and the approval planning as well as the full detail planning for all disciplines (architectural planning, structural and façade engineering, building physics, HVAC engineering and laboratory planning). Furthermore, the reinforced concrete structure built on a pile foundation had to be designed blast wave resistant. In addition the requirement for gas tightness had to be considered in the building design, including the execution of an internal air supply in the case of emergency.
A rapid and sensitive LC–MS/MS method for quantification of quercetin‐3‐O‐β‐d‐glucopyranosyl‐7‐O‐β‐d‐gentiobioside in plasma and its application to a pharmacokinetic study
Authors: He Xin , Tao Guizhou , Gao Hang , Li Keyan , Zhang Yazhuo , Sun Limin , Zhang Yingjie 
Published: February 2016

AbstractA rapid and sensitive LC–MS/MS method with good accuracy and precision was developed and validated for the pharmacokinetic study of quercetin‐3‐O‐β‐d‐glucopyranosyl‐7‐O‐β‐d‐gentiobioside (QGG) in Sprague–Dawley rats. Plasma samples were simply precipitated by methanol and then analyzed by LC–MS/MS. A Venusil® ASB C18 column (2.1 × 50 mm, i.d. 5 μm) was used for separation, with methanol–water (50:50, v/v) as the mobile phase at a flow rate of 300 μL/min. The optimized mass transition ion‐pairs (m/z) for quantitation were 787.3/301.3 for QGG, and 725.3/293.3 for internal standard. The linear range was 7.32–1830 ng/mL with an average correlation coefficient of 0.9992, and the limit of quantification was 7.32 ng/mL. The intra‐ and inter‐day precision and accuracy were less than ±15%. At low, medium and high quality control concentrations, the recovery and matrix effect of the analyte and IS were in the range of 89.06–92.43 and 88.58–97.62%, respectively. The method was applied for the pharmacokinetic study of QGG in Sprague–Dawley rats. Copyright © 2016 John Wiley & Sons, Ltd.
Porphyrin/Platinum(II) C^N^N Acetylide Complexes: Synthesis, Photophysical Properties, and Singlet Oxygen Generation
Authors: Jana Atanu , McKenzie Luke , Wragg Ashley B. , Ishida Masatoshi , Hill Jonathan P. , Weinstein Julia A. , Baggaley Elizabeth , Ward Michael D. 
Published: February 2016

AbstractA new class of substituted porphyrins has been developed in which a different number of cyclometalated PtII C^N^N acetylides and polyethylene glycol (PEG) chains are attached to the meso positions of the porphyrin core, which are meant for photophysical, electrochemical, and in vitro light‐induced singlet oxygen (1O2) generation studies. All of these ZnII porphyrin–PtII C^N^N acetylide conjugates show moderate to high (ΦΔ=0.55 to 0.63) singlet oxygen generation efficiency. The complexes are soluble in organic solvents but, despite the PEG substituents, slowly aggregate in aqueous solvent systems. These conjugates also exhibit interesting photophysical properties, including near‐complete photoinduced energy transfer (PEnT) through the rigid acetylenic bond(s) from the PtII C^N^N antenna units to the ZnII porphyrin core, which shows sensitized luminescence, as shown by quenching of PtII C^N^N‐based luminescence. Electrochemical measurements show a set of redox processes that are approximately the sum of what is observed for the PtII C^N^N acetylide and ZnII porphyrin units. UV/Vis spectroscopic properties are supported by DFT calculations.
Lewis Acid Catalyzed Synthesis of Cyanidophosphates
Authors: Bläsing Kevin , Ellinger Stefan , Harloff Jörg , Schulz Axel , Sievert Katharina , Täschler Christoph , Villinger Alexander , Zur Täschler Cornelia 
Published: February 2016

AbstractSalts containing new cyanido(fluorido)phosphate anions of the general formula [PF6−n(CN)n]− (n=1–4) were synthesized by a very mild Lewis‐acid‐catalyzed synthetic protocol and fully characterized. All [PF6−n(CN)n]− (n=1–4) salts could be isolated on a preparative scale. It was also possible to detect the [PF(CN)5]− but not the [P(CN)6]− anion. The best results with respect to purity, yield, and low cost were obtained when the F−/CN− substitution reactions were carried out in ionic liquids.
Lipid Nanotube Tailored Fabrication of Uniquely Shaped Polydopamine Nanofibers as Photothermal Converters
Authors: Ding Wuxiao , Chechetka Svetlana A. , Masuda Mitsutoshi , Shimizu Toshimi , Aoyagi Masaru , Minamikawa Hiroyuki , Miyako Eijiro 
Published: February 2016

AbstractHelically coiled and linear polydopamine (PDA) nanofibers were selectively fabricated with two different types of lipid nanotubes (LNTs) that acted as templates. The obtained coiled PDA‐LNT hybrid showed morphological advantages such as higher light absorbance and photothermal conversion effect compared to a linear counterpart. Laser irradiation of the coiled PDA‐LNT hybrid induced a morphological change and subsequent release of the encapsulated guest molecule. In cellular experiments, the coiled PDA‐LNT efficiently eliminated HeLa cells because of its strong affinity with the tumor cells. This work illustrates the first approach to construct characteristic morphologies of PDA nanofibers using LNTs as simple templates, and the coiled PDA‐LNT hybrid exhibits attractive photothermal features derived from its unique coiled shape.
Messung und thermodynamische Bewertung von VOC‐ und Wasser‐Adsorptionsisothermen an granulierten Aktivkohlen
Authors: Fickinger Daniel , Zellner Stefan , Kimmerle Klaus , Schippert Egbert 
Published: February 2016

AbstractMit einer Versuchsanlage wurden Adsorptionsisothermen auf granulierten Aktivkohlen bei Temperauren zwischen 50 °C und 130 °C gemessen. Trotz der kinetischen Überlegenheit von Aktivkohlefasergewebe, das ursprünglich ausschließlich vermessen wurde, konnte mittels einer neuen Probenaufnahme für granulierte Aktivkohle gezeigt werden, dass mit der Versuchsanlage auch Adsorptionsisothermen an diesen Materialien schnell, kostengünstig und in einem großen Messbereich bestimmt werden können. Adsorptionsisothermen wurden mit dem ALIc‐Modell sowie den Modellen von Dubinin‐Asthakov, Toth und Do&Do angepasst und die Modelle bzgl. Anpassungsgüte und anderer Kriterien verglichen und bewertet.
Predictors of Medical Management in Patients Undergoing Elective Cardiac Catheterization for Chronic Ischemic Heart Disease
Authors: Atreya Auras R. , Sivalingam Senthil K. , Arora Sonali , Kashef Mohammad Amin , Fitzgerald Janice , Visintainer Paul , Lotfi Amir , Rothberg Michael B. 
Published: February 2016

ABSTRACTBackgroundCompared with medical therapy, percutaneous coronary intervention (PCI) does not reduce mortality or myocardial infarction in patients with stable angina. Therefore, PCI should be guided by refractory anginal symptoms and not just lesion characteristics.HypothesisWe hypothesized that angiographic lesion characteristics and stress test results would have a greater role in the decision to proceed with PCI than would symptom severity.MethodsWe performed a retrospective cohort study of patients undergoing elective cardiac catheterization and possible PCI at an academic medical center. Anginal symptoms, optimal medical therapy, antianginal therapy, stress test results, and angiographic lesions (including American College of Cardiology/American Heart Association [ACC/AHA] lesion type) were analyzed. Logistic regression was used to determine predictors of medical management among patients not referred for coronary artery bypass surgery.ResultsOf the 207 patients with obstructive lesions amenable to PCI, 163 underwent PCI and 44 were referred to medical therapy. In the multivariable logistic model, the following variables were associated with medical management: advancing age (odds ratio [OR] per 1 year: 0.94, 95% confidence interval [CI]: 0.91‐0.98), chronic kidney disease (OR: 0.23, 95% CI: 0.06‐0.95), distal location (OR: 0.21, 95% CI: 0.09‐0.48), and ACC/AHA type C lesion (OR: 0.08, 95% CI: 0.03‐0.22). There was no association with sex, race, symptoms, optimal medical therapy, maximal antianginal therapy, referral status, or type of interventional cardiologist (academic vs private practice).ConclusionsFor patients undergoing cardiac catheterization for stable angina, the decision to proceed to PCI vs medical management appears to depend largely on patient and angiographic characteristics, but not on symptoms or ischemia. Distal and high‐risk lesions (ACC/AHA type C) are more often referred for medical therapy.
Implications of the New US Cholesterol Guidelines in the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil)
Authors: Bittencourt Marcio Sommer , Staniak Henrique Lane , Pereira Alexandre Costa , Santos Itamar S. , Duncan Bruce B. , Santos Raul D. , Blaha Michael J. , Jones Steve R. , Toth Peter P. , Bensenor Isabela M. , Lotufo Paulo A. 
Published: February 2016

ABSTRACTBackgroundThe new US guidelines for the primary prevention of cardiovascular disease have substantially changed the approach to hyperlipidemia treatment. However, the impact of those recommendations in other populations is limited. In the present study, we evaluated the potential implications of those recommendations in the Brazilian population.HypothesisThe new U.S. recommendations may increase the proportion of individuals who are candidates for statin therapy.MethodsWe included all participants of the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) without known cardiovascular disease. We calculated the indication for statin therapy according to the current Brazilian recommendations and the new US guidelines, using both the 5.0% and the 7.5% risk cutoffs to recommend treatment, and compared their impact in the Brazilian population stratified by age, sex, and race.ResultsAlthough the current guidelines would recommend treatment for 5499 (39.1%) individuals, the number of individuals eligible for statin therapy increased to 6014 (42.7%) and to 7130 (50.7%) using the 7.5% and 5% cutoffs, respectively (P < 0.001). This difference is more pronounced for older individuals, and virtually all individuals age >70 years would be eligible for statins, whereas the new guidelines would reduce the number of candidates for statin therapy in individuals age <45 years.ConclusionsThe application of the new US guidelines for the use of lipid‐lowering medications in a large middle‐aged Brazilian cohort would result in a significant increase in the population eligible for statins. This is largely driven by males and older individuals. Additional cost‐effectiveness analyses are needed to define the appropriateness of this strategy in the Brazilian population.
Computational evaluation of aortic occlusion and the proposal of a novel, improved occluder: Constrained endo‐aortic balloon occlusion
Authors: de Vaal M. H. , Gee M. W. , Stock U. A. , Wall W. A. 
Published: February 2016

SummaryBecause aortic occlusion is arguably one of the most dangerous aortic manipulation maneuvers during cardiac surgery in terms of perioperative ischemic neurological injury, the purpose of this investigation is to assess the structural mechanical impact resulting from the use of existing and newly proposed occluders. Existing (clinically used) occluders considered include different cross‐clamps (CCs) and endo‐aortic balloon occlusion (EABO). A novel occluder is also introduced, namely, constrained EABO (CEABO), which consists of applying a constrainer externally around the aorta when performing EABO. Computational solid mechanics are employed to investigate each occluder according to a comprehensive list of functional requirements. The potential of a state of occlusion is also considered for the first time. Three different constrainer designs are evaluated for CEABO. Although the CCs were responsible for the highest strains, largest deformation, and most inefficient increase of the occlusion potential, it remains the most stable, simplest, and cheapest occluder. The different CC hinge geometries resulted in poorer performance of CC used for minimally invasive procedures than conventional ones. CEABO with a profiled constrainer successfully addresses the EABO shortcomings of safety, stability, and positioning accuracy, while maintaining its complexities of operation (disadvantage) and yielding additional functionalities (advantage). Moreover, CEABO is able to achieve the previously unattainable potential to provide a clinically determinable state of occlusion. CEABO offers an attractive alternative to the shortcomings of existing occluders, with its design rooted in achieving the highest patient safety. Copyright © 2016 John Wiley & Sons, Ltd.
Standardization of cryopreserved peripheral blood mononuclear cells through a resting process for clinical immunomonitoring—Development of an algorithm
Authors: Wang Lei , Hückelhoven Angela , Hong Jian , Jin Nan , Mani Jiju , Chen Bao‐an , Schmitt Michael , Schmitt Anita 
Published: February 2016

AbstractFlow cytometry, as a powerful tool for immunomonitoring and quality control of peripheral blood mononuclear cells (PBMCs), is routinely used in clinical studies. However, flow cytometry based assays for cryopreserved peripheral blood mononuclear cells (cPBMCs) constitute a challenge. Down‐regulation of surface and intracellular markers, as well as impairment of cell function might result from cryopreservation. Furthermore, protocols for resting cPBMCs are available but diverse. Therefore, we performed a standardization of the resting process concerning resting position, cell concentration, resting period and material of cell culture tubes as well as culture media. We further investigated the influence of resting on the phenotype and functionality of T cells comparing fresh PBMCs as gold standard to rested and non‐rested cPBMCs. Polychromatic flow cytometry staining, peptide‐MHC class I restricted tetramer staining and intracellular cytokine staining as major methods were used. Our results revealed that a horizontal position, a cell concentration of 2 to 5 × 106 cells/ml and an overnight resting phase is beneficial to eliminate dead or dying cells in cPBMCs with a mean cell loss of 14% overall cell populations. In addition, the quality and quantity of regulatory T cells and antigen specific T cells recovered upon resting. For multifunctional T cells a decrease of activation threshold in the way of a twofold mean fluorescence intensity (MFI) and increase of degranulation marker CD107a, co‐stimulatory marker CD28, adhesion molecule CD62L as well as the ability to secrete antiviral cytokines like interferon gamma (IFN‐γ), tumor necrosis factor (TNF), and interleukin 2 (IL‐2) comparable to fresh PBMCs were observed. However, based upon our data resting is not helpful for the flow cytometric analyses of myeloid‐derived suppressor cells (MDSCs) and large/intermediate size lymphocytes which rather decreased/vanished ex vivo. Therefore, we developed an algorithm to indicate for which cell population and for which type of analyses the resting process is useful or not. © 2016 International Society for Advancement of Cytometry
A long journey coming to fruition: In sight of the preselection T‐cell repertoire
Authors: Ciucci Thomas , Bosselut Rémy 
Published: February 2016

In addition to MHC restriction and its structural correlate the recognition of an MHC‐peptide complex by the TCR, T‐cell reactivity is constrained by positive and negative selection in the thymus. While mouse genetic studies have provided compelling evidence for both processes, the actual impact of selection on the mature T‐cell repertoire has remained difficult to assess, in particular because it has so far not been possible to follow the intrathymic differentiation of antigen‐specific T cells carrying endogenous TCR specificities. In this issue of the European Journal of Immunology, Hesnard et al. [Eur. J. Immunol. 2016. 46: 560‐569] report the detection of human antigen‐specific immature thymocytes, thereby opening the way to addressing these questions. Here, we discuss the implications of this technological advance.
Photoinduced and Self‐Activated Nuclease Activity of Copper(II) Complexes with N‐(Quinolin‐8‐yl)quin­olin‐8‐sulfonamide – DNA and Bovine Serum Albumin Binding
Authors: Pascual‐Álvarez Alejandro , Topala Tamara , Estevan Francisco , Sanz Francisca , Alzuet‐Piña Gloria 
Published: February 2016

AbstractTwo CuII complexes with a new quinoline sulfonamide derivative and phenanthroline (phen), [Cu(QSQ)(phen)]ClO4·0.5H2O (1) and [Cu(QSQ)(phen)(H2O)]ClO4 (2) [HQSQ = N‐(quinolin‐8‐yl)quinolin‐8‐sulfonamide], have been synthesized and physicochemically characterized. Single‐crystal X‐ray diffraction studies have revealed a highly distorted trigonal‐bipyramidal structure for 1 (τ = 0.68) and an almost perfect trigonal‐bipyramidal geometry for 2 (τ = 0.92). DNA binding studies, which were performed by thermal denaturation, viscometry, fluorescence spectroscopy, and cyclic voltammetry, indicated a partial intercalation of 1 with Kapp = 2.45 × 106 M–1. The nuclease activity of 1 was investigated upon photoirradiation, with ascorbate/H2O2 as the activating agent, and also in the absence of any external reagent. In all cases, 1 was able to perform DNA cleavage, and its nuclease efficiency varied in the order ascorbate/H2O2 > photoirradiation > without external cofactors. Mechanistic investigations suggest an oxidative cleavage of DNA involving reactive oxygen species (ROS). The protein binding ability of 1 was also studied with bovine serum albumin (BSA) as a model protein.
Synthesis of DNA‐Intercalating 6H‐Benzo[c]chromen‐6‐one Derivatives through a Strategic Combination of Garratt–Braverman and Minisci Acyloxylation Reactions
Authors: Bhattacharya Prabuddha , Mandal Santi M. , Basak Amit 
Published: February 2016

AbstractA new strategy for the synthesis of 6H‐benzo[c]chromen‐6‐ones through judicious use of Garratt–Braverman (GB) Cyclization and Minisci acyloxylation reactions in moderate to good yield is reported. The uniqueness of the GB reaction is exemplified in providing the required biaryl esters, which could be successfully converted into the target skeleton by means of Minisci reaction on the free carboxylates. Ethidium bromide displacement and UV‐based assay on the final molecules established them as DNA intercalators with binding constants in the range of about 104.