bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noether’s theorem and Ward-Takahashi identities from homotopy algebras
Authors: Konosu Keisuke , Totsuka-Yoshinaka Jojiro 
Published: September 2024

Abstract
We derive the new identity in homotopy algebras which directly corresponds to the Schwinger-Dyson equations in quantum field theory. As an application, we derive the Ward-Takahashi identities. We demonstrate that the Ward-Takahashi identities are reproduced in several examples. In general, our formula contains divergence. We mediate this problem by introducing stubs known in the context of string field theory. With the regularization, we can calculate the anomaly such as axial U(1) anomaly in vector-like U(1) gauge theory.
The phase space distance between collider events
Authors: Cai Tianji , Cheng Junyi , Craig Nathaniel , Koszegi Giacomo , Larkoski Andrew J. 
Published: September 2024

Abstract
How can one fully harness the power of physics encoded in relativistic N-body phase space? Topologically, phase space is isomorphic to the product space of a simplex and a hypersphere and can be equipped with explicit coordinates and a Riemannian metric. This natural structure that scaffolds the space on which all collider physics events live opens up new directions for machine learning applications and implementation. Here we present a detailed construction of the phase space manifold and its differential line element, identifying particle ordering prescriptions that ensure that the metric satisfies necessary properties. We apply the phase space metric to several binary classification tasks, including discrimination of high-multiplicity resonance decays or boosted hadronic decays of electroweak bosons from QCD processes, and demonstrate powerful performance on simulated data. Our work demonstrates the many benefits of promoting phase space from merely a background on which calculations take place to being geometrically entwined with a theory’s dynamics.
Tomographic Fourier extension identities for submanifolds of $${\mathbb {R}}^n$$
Authors: Bennett Jonathan , Nakamura Shohei , Shiraki Shobu 
Published: September 2024

AbstractWe establish identities for the composition $$T_{k,n}(|\widehat{gd\sigma }|^2)$$

T

k
,
n

(
|

g
d
σ

^

|
2

)

, where $$g\mapsto \widehat{gd\sigma }$$

g
↦

g
d
σ

^

is the Fourier extension operator associated with a general smooth k-dimensional submanifold of $${\mathbb {R}}^n$$

R

n

, and $$T_{k,n}$$

T

k
,
n

is the k-plane transform. Several connections to problems in Fourier restriction theory are presented.
The state as a model for AI control and alignment
Authors: Elsner Micha 
Published: September 2024

AbstractDebates about the development of artificial superintelligence and its potential threats to humanity tend to assume that such a system would be historically unprecedented, and that its behavior must be predicted from first principles. I argue that this is not true: we can analyze multiagent intelligent systems (the best candidates for practical superintelligence) by comparing them to states, which also unite heterogeneous intelligences to achieve superhuman goals. States provide a model for several problems discussed in the literature on superintelligence, such as principal-agent problems and Instrumental Convergence. Philosophical arguments about governance, therefore, provide possible solutions to these problems, or point out problems in previously suggested solutions. In particular, the liberal concept of checks and balances, and Hannah Arendt’s concept of legitimacy, describe how state behavior is constrained by the preferences of constituents that could also apply to artificial systems. However, they also point out ways in which present-day computational developments could destabilize the international order by reducing the number of decision-makers involved in state actions. Thus, interstate competition not only serves as a model for the behavior of dangerous computational intelligences but also as the impetus for their development.
Differences among the total electron content derived by radio occultation, global ionospheric maps and satellite altimetry
Authors: Wu M. J. , Guo P. , Ma X. , Xue J. C. , Liu M. , Hu X. G. 
Published: September 2024

AbstractIn recent years, significant progress has been in ionospheric modeling research through data ingestion and data assimilation from a variety of sources, including ground-based global navigation satellite systems, space-based radio occultation and satellite altimetry (SA). Given the diverse observing geometries, vertical data coverages and intermission biases among different measurements, it is imperative to evaluate their absolute accuracies and estimate systematic biases to determine reasonable weights and error covariances when constructing ionospheric models. This study specifically investigates the disparities among the vertical total electron content (VTEC) derived from SA data of the Jason and Sentinel missions, the integrated VTEC from the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) and global ionospheric maps (GIMs). To mitigate the systematic bias resulting from differences in satellite altitudes, the vertical ranges of various VTECs are mapped to a standardized height. The results indicate that the intermission bias of SA-derived VTEC remains relatively stable, with Jason-1 serving as a benchmark for mapping other datasets. The mean bias between COSMIC and SA-derived VTEC is minimal, suggesting good agreement between these two space-based techniques. However, COSMIC and GIM VTEC exhibit remarkable seasonal discrepancies, influenced by the solar activity variations. Moreover, GIMs demonstrate noticeable hemispheric asymmetry and a degradation in accuracy ranging from 0.7 to 1.7 TECU in the ocean-dominant Southern Hemisphere. While space-based observations effectively illustrate phenomena such as the Weddell Sea anomaly and longitudinal ionospheric characteristics, GIMs tend to exhibit a more pronounced mid-latitude electron density enhancement structure.
Methodological steps forward in toxicological in vitro screening of mineral wools in primary rat alveolar macrophages and normal rat mesothelial NRM2 cells
Authors: Ziemann Christina , Schulz Florian , Koch Christoph , Solvang Mette , Bitsch Annette 
Published: September 2024

AbstractMan-made vitreous fibers (MMVF) comprise diverse materials for thermal and acoustic insulation, including stone wool. Depending on dimension, durability, and dose, MMVF might induce adverse health effects. Therefore, early predictive in vitro (geno)toxicity screening of new MMVF is highly desired to ensure safety for exposed workers and consumers. Here, we investigated, as a starting point, critical in vitro screening determinants and pitfalls using primary rat alveolar macrophages (AM) and normal rat mesothelial cells (NRM2). A stone wool fiber (RIF56008) served as an exemplary MMVF (fibrous vs. ground to estimate impact of fiber shape) and long amosite (asbestos) as insoluble fiber reference. Materials were comprehensively characterized, and in vivo-relevant in vitro concentrations defined, based on different approaches (low to supposed overload: 0.5, 5 and 50 µg/cm2). After 4–48 h of incubation, certain readouts were analyzed and material uptake was investigated by light and fluorescence-coupled darkfield microscopy. DNA-strand break induction was not morphology-dependent and nearly absent in both cell types. However, NRM2 demonstrated material-, morphology- and concentration-dependent membrane damage, CINC-1 release, reduction in cell count, and induction of binucleated cells (asbestos > RIF56008 > RIF56008 ground). In contrast to NRM2, asbestos was nearly inactive in AM, with CINC-1 release solely induced by RIF56008. In conclusion, to define an MMVF-adapted, predictive in vitro (geno)toxicity screening tool, references, endpoints, and concentrations should be carefully chosen, based on in vivo relevance, and sensitivity and specificity of the chosen cell model. Next, further endpoints should be evaluated, ideally with validation by in vivo data regarding their predictivity.
Bar adsorptive microextraction and liquid chromatography-diode array detection of synthetic cannabinoids in oral fluid
Authors: Ahmad Samir M. , Neng Nuno R. , Queirós Cláudio R. , Gaspar Helena , Nogueira José Manuel F. 
Published: September 2024

AbstractIn recent years, synthetic cannabinoids (SCs) have become a major public health issue. For this reason, there is a need for innovative analytical methods that allow its monitoring in biological matrices. In this work, we propose a novel methodology to screen eight SCs (AM-694, cumyl-5F-PINACA, MAM-2201, 5F-UR-144, JWH-018, JWH-122, UR-144 and APINACA) in oral fluids. A bar adsorptive microextraction method followed by microliquid desorption combined with high-performance liquid chromatography with diode array detection (BAµE-µLD/HPLC-DAD) was developed to monitor the target SCs. The main factors affecting the BAµE technology were fully optimized for oral fluid analysis. Under optimized experimental conditions, the proposed methodology showed good linear dynamic ranges from 20.0 to 2000.0 µg L−1 (r2 > 0.99, relative residuals < 15%), limits of detection between 2.0 and 5.0 µg L−1 and suitable average recovery yields (87.9–100.5%) for the eight studied SCs. The intra- and interday accuracies (bias ≤ ± 14.7%) and precisions (RSD ≤ 14.9%) were also evaluated at three spiking levels. The validated methodology was then assayed to oral fluid samples collected from several volunteers. The proposed analytical approach showed remarkable performance and could be an effective alternative for routine monitoring of the target compounds in oral fluid.
Graphical Abstract
Personalised PET imaging in oncology: an umbrella review of meta-analyses to guide the appropriate radiopharmaceutical choice and indication
Authors: Kirienko Margarita , Gelardi Fabrizia , Fiz Francesco , Bauckneht Matteo , Ninatti Gaia , Pini Cristiano , Briganti Alberto , Falconi Massimo , Oyen Wim J. G. , van der Graaf Winette T. A. , Sollini Martina 
Published: September 2024

Abstract
Purpose
For several years, oncological positron emission tomography (PET) has developed beyond 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). This umbrella review of meta-analyses aims to provide up-to-date, comprehensive, high-level evidence to support appropriate referral for a specific radiopharmaceutical PET/computed tomography (CT) or PET/magnetic resonance (MR) in the diagnosis and staging of solid cancers other than brain malignancies.

Methods
We performed a systematic literature search on the PubMed/MEDLINE and EMBASE databases for meta-analyses assessing the accuracy of PET/CT and/or PET/MRI with [18F]FDG, somatostatin- receptor-targeting 68Ga-DOTA-peptides, 18F-labelled dihydroxyphenylalanine ([18F]DOPA), prostate-specific membrane antigen (PSMA)-targeted radioligands, and fibroblast activation protein inhibitors (FAPI) in the diagnosis/disease characterisation and staging of solid cancers other than brain tumours.

Results
The literature search yielded 449 scientific articles. After screening titles and abstracts and applying inclusion and exclusion criteria, we selected 173 meta-analyses to assess the strength of evidence. One article was selected from references. Sixty-four meta-analyses were finally considered. The current evidence corroborates the role of [18F]FDG as the main player in molecular imaging; PSMA tracers are useful in staging and re-staging prostate cancer; somatostatin-targeting peptides (e.g. [68Ga]Ga- DOTA-TOC and -TATE) or [18F]DOPA are valuable in neuroendocrine tumours (NETs). FAPI has emerged in gastric cancer assessment. According to search and selection criteria, no satisfactory meta-analysis was selected for the diagnosis/detection of oesophageal cancer, the diagnosis/detection and N staging of small cell lung cancer and hepatic cell carcinoma, the diagnosis/detection and M staging of melanoma and Merkel cell carcinoma, cervical, vulvar and penis cancers, the N and M staging of lung and gastroenteropancreatic NET, testicular cancer, and chondrosarcoma, and the M staging of differentiated thyroid, bladder and anal cancers.

Conclusion
The comprehensive high-level evidence synthesised in the present umbrella review serves as a guiding compass for clinicians and imagers, aiding them in navigating the increasingly intricate seascape of PET examinations.
Trend, disparities, and projection analysis of public data on shoulder fractures in Sweden: a retrospective analysis of two hundred and sixty two thousand, four hundred and forty four fractures
Authors: Magnéli Martin , Axenhus Michael 
Published: September 2024

Abstract
Purpose
We aimed to identify temporal trends, seasonal changes and regional differences in shoulder fractures in Sweden during 2008–2022.

Methods
Data from the Swedish National Board of Health and Welfare were used to assess incidence rates per 100,000 people, categorized by sex, age, and month.

Results
Results showed an average of 17,496 fractures annually, with a decline in 2020 followed by a resurgence in 2021–2022. Elderly women, especially those over 65, had higher rates. Winter months exhibited increased incidence.

Conclusions
Projection analysis indicated a gradual decrease in fractures over the next 15 years. Understanding these patterns can inform preventive strategies and resource allocation for shoulder fractures in Sweden.
HOXD12 defines an age-related aggressive subtype of oligodendroglioma
Authors: Nuechterlein Nicholas , Cimino Sadie , Shelbourn Allison , Ha Vinny , Arora Sonali , Rajan Sharika , Shapiro Linda G. , Holland Eric C. , Aldape Kenneth , McGranahan Tresa , Gilbert Mark R. , Cimino Patrick J. 
Published: September 2024

AbstractOligodendroglioma, IDH-mutant and 1p/19q-codeleted has highly variable outcomes that are strongly influenced by patient age. The distribution of oligodendroglioma age is non-Gaussian and reportedly bimodal, which motivated our investigation of age-associated molecular alterations that may drive poorer outcomes. We found that elevated HOXD12 expression was associated with both older patient age and shorter survival in the TCGA (FDR < 0.01, FDR = 1e−5) and the CGGA (p = 0.03, p < 1e−3). HOXD12 gene body hypermethylation was associated with older age, higher WHO grade, and shorter survival in the TCGA (p < 1e−6, p < 0.001, p < 1e−3) and with older age and higher WHO grade in Capper et al. (p < 0.002, p = 0.014). In the TCGA, HOXD12 gene body hypermethylation and elevated expression were independently prognostic of NOTCH1 and PIK3CA mutations, loss of 15q, MYC activation, and standard histopathological features. Single-nucleus RNA and ATAC sequencing data showed that HOXD12 activity was elevated in neoplastic tissue, particularly within cycling and OPC-like cells, and was associated with a stem-like phenotype. A pan-HOX DNA methylation analysis revealed an age and survival-associated HOX-high signature that was tightly associated with HOXD12 gene body methylation. Overall, HOXD12 expression and gene body hypermethylation were associated with an older, atypically aggressive subtype of oligodendroglioma.
Exploring the relationship between morphea and malignancy: a decade-long single-center study of 204 patients
Authors: Lyakhovitsky Keren , Damiani Giovanni , Mimouni Daniel , Aronovich Anna 
Published: September 2024

AbstractThe association between systemic scleroderma and malignancy is well-documented, but there is limited data on the relationship between morphea and malignancy. This study aims to assess the incidence and types of malignancies in morphea patients, comparing demographics, clinical characteristics, treatments, and outcomes between those with and without malignancy. We conducted a retrospective study of 204 morphea patients treated at Rabin Medical Center between 2012 and 2023. Data on demographics, clinical subtypes, comorbidities, treatments, and outcomes were collected. Patients were categorized based on malignancy status and the timing of malignancy relative to their morphea diagnosis. Among the 204 patients (154 women and 50 men, mean age 53.7 ± 20 years), 47 (23%) developed malignancies. In 29 patients (61.7%), malignancy occurred before the onset of morphea; in 23 patients (48.9%), it occurred after morphea. Five patients (10.6%) had malignancies both before and after the diagnosis of morphea. Patients with malignancy were significantly older than those without (64.7 ± 15.1 years vs. 50.3 ± 20 years, p < 0.0001). The all-cause mortality rate was higher in the malignancy group compared to those without malignancy (23.4% vs. 3.8%, p = 0.00002). Moreover, mortality was higher in patients whose malignancy occurred after morphea than in those whose malignancy preceded morphea (26% vs. 17.2%). The most common post-morphea malignancies in our cohort included non-melanoma skin cancer, cervical cancer, breast cancer, stomach cancer, and lung cancer. The most common pre-morphea malignancies included breast cancer, non-melanoma skin cancer, colon cancer, prostate cancer, and testicular cancer. This study suggests potential associations between morphea and malignancies, influenced by patient age, sequence of diagnosis, and treatment regimens. Further control studies are needed to explore these relationships more definitively.
Profiles of muscle-specific oxygenation responses and thresholds during graded cycling incremental test
Authors: Sendra-Pérez Carlos , Encarnacion-Martinez Alberto , Salvador-Palmer Rosario , Murias Juan M. , Priego-Quesada Jose I. 
Published: September 2024

Abstract
Compared to the determination of exercise thresholds based on systemic changes in blood lactate concentrations or gas exchange data, the determination of breakpoints based on muscle oxygen saturation offers a valid alternative to provide specific information on muscle-derived thresholds. Our study explored the profiles and timing of the second muscle oxygenation threshold (MOT2) in different muscles. Twenty-six cyclists and triathletes (15 male: age = 23 ± 7 years, height = 178 ± 5 cm, body mass = 70.2 ± 5.3 kg; 11 female: age = 22 ± 4 years, height = 164 ± 4 cm, body mass = 58.3 ± 8.1 kg) performed a graded exercise test (GXT), on a cycle ergometer. Power output, blood lactate concentration, heart rate, rating of perceived exertion, skinfolds and muscle oxygen saturation were registered in five muscles (vastus lateralis, biceps femoris, gastrocnemius medialis, tibialis anterior and triceps brachii) and percentage at which MOT2 occurred for each muscle was determinated using the Exponential Dmax. The results of Statistical Parametric Mapping and ANOVA showed that, although muscle oxygenation displayed different profiles in each muscle during a GXT, MOT2 occurred at a similar percentage of the GXT in each muscle (77% biceps femoris, 75% tibalis anterior, 76% gastrocnemius medialis and 72% vastus lateralis) and it was similar that systemic threshold (73% of the GXT). In conclusion, this study showed different profiles of muscle oxygen saturation in different muscles, but without notable differences in the timing for MOT2 and concordance with systemic threshold. Finally, we suggest the analysis of the whole signal and not to simplify it to a breakpoint.
Phoenix criteria for sepsis: are these enough to guide a clinician?
Authors: Rodriguez Isadora , Deep Akash 
Published: September 2024

AbstractSepsis is the leading cause of mortality in children worldwide. There is a paucity of data on the criteria used to define sepsis and septic shock and predict mortality. Schlapbach et al. published Phoenix criteria to define sepsis in JAMA in 2024. Previously, paediatricians have used systemic inflammatory response syndrome (SIRS) criteria, but these criteria lack sensitivity and specificity. This group recommends that sepsis in children be identified by a Phoenix Sepsis Score of at least 2 points in children with suspected infection, which indicates potentially life-threatening dysfunction of the respiratory, cardiovascular, coagulation, and/or neurological systems. Though included in the 8-point criteria, important criteria like renal and liver are missing from the main criteria. We remain worried about the way these criteria got excluded from the main criteria. Therefore, in this brief report, whilst commending the authors for this stelar task, we highlight the main pitfalls in these criteria especially the renal, neurologic, and liver criteria. These criteria have been shown to be independently associated with outcomes, and we recommend that in the future iterations of the criteria, renal and liver criteria should be defined according to latest definitions and the task force consider utilizing latest criteria for each organ system involved within the formulated criteria.Conclusion: In conclusion, Phoenix criteria are a step in the right direction to define life-threatening organ dysfunction in sepsis, but clinicians need to be mindful that diagnosis/treatment of less severe sepsis should not be delayed if these criteria are not met. Therefore, local early detection and management tools for sepsis should be followed.

What is Known:• There has always been a quest for a definition for pediatric sepsis. There are limitations to the previous pediatric sepsis criteria which were published in 2005 by the International Pediatric Sepsis Consensus Conference (IPSCC). IPSCC defines sepsis as a suspected or confirmed infection in the presence of systemic inflammatory response syndrome (SIRS). These new Phoenix Pediatric Sepsis (PPS) criteria for sepsis and septic shock are intended to identify children with life-threatening organ dysfunction due to infection, and the score was developed based on a very large pediatric dataset.

What is New:• Though the intention of Phoenix criteria is to help identify children with life threatening organ dysfunction, unfortunately the crietria will miss signs of early sepis. In this manuscript, we point out some of the drawbacks of these criteria which need to be borne in mind while applying these criteria.
COVID-19 vaccines: anaphylaxis and anxiety
Authors: Teufelberger Andrea R. , Dan Andrada-Renata , Irmler Linda , Wolf Peter , Kränke Birger 
Published: September 2024

Summary
Background
Vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) was one crucial element to overcome the coronavirus disease 2019 (COVID-19) pandemic. Even though anaphylaxis to vaccines is rare, 47 patients came to the Allergy Unit at the University Hospital Graz, Austria, reporting immediate anaphylactoid symptoms after administration of COVID-19 vaccines. In addition, 29 patients with known drug-induced anaphylaxis wanted to be tested for a possible sensitization against COVID-19 vaccines or excipients, such as polyethylene glycol (PEG) or polysorbate 80 (PS80) before the first COVID-19 vaccination. Skin prick tests and intradermal tests were performed in all 76 patients, mostly using PEG 2000, and/or PS80. Skin prick tests with COVID-19 vaccines were performed depending on availability.

Objective
Our aim was to characterize this patient cohort in terms of patients’ anaphylactoid responses, their willingness to future vaccinations against SARS-Cov‑2, and reasons for their decision.

Methods
We developed a questionnaire and analyzed 34 completed copies.

Results
Of the 47 patients with anaphylactoid reactions to COVID-19 vaccination, most were female (40 female/7 male). The skin tests, even when performed with the respective COVID-19 vaccine, were negative in all but one patient. Most patients who experienced anaphylactoid reactions after a COVID-19 vaccination, did not want another COVID-19 vaccination at the time of answering the questionnaire because of anxiety for another anaphylactoid response at the next shot. Premedication with antihistamines significantly lowered (n = 74 vaccinations) the severity of anaphylactoid responses after COVID-19 vaccinations.

Conclusion
Anxiety about another anaphylactoid episode hinders patients to be vaccinated against SARS-CoV‑2 again. Premedication with antihistamines and collaboration of allergologists with psychologists might lower the risk of an anaphylactic/anaphylactoid response as well anxiety in drug-induced anaphylactic patients.