bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Output Feedback Model Predictive Control: A Stochastic Approach
Authors: Mohammadkhani Mohammadali , Bayat Farhad , Jalali Ali Akbar 
Published: July 2017

AbstractThis paper addresses the robust explicit model predictive control scheme for linear systems with input and output constraint in the presence of disturbances and noise. Conditions for disturbance rejection are established by incorporating a full state/disturbance observer. The separation principle is applied to design an optimal observer in the unconstrained problem. Then, an efficient algorithm is developed to explicitly design observer gains by minimizing a quadratic performance criterion. It is shown that the solution includes a set of regions with piecewise affine functions of the state and reference vectors and a set of regions with optimal observers. In the proposed method, two sets of partitions associated with the control law and the observer gains are obtained. Therefore, the online computation includes finding the active regions of both observer and control law partitions in which the current state is located. The proposed technique is particularly attractive for a wide range of practical problems where the exact model of the actual system is not available.
Effects of therapy balls on children diagnosed with attention deficit hyperactivity disorder
Authors: Taipalus Abbie C. , Hixson Michael D. , Kanouse Sandra K. , Wyse Robert D. , Fursa Sophie 
Published: July 2017

Therapy balls are air‐filled rubber balls ranging from 20 to 30 in. in diameter that are sometimes used in place of traditional 4‐legged chairs in classrooms. Unfortunately, research on the effects of therapy balls as chairs is limited. Therefore, this study evaluated the effects of therapy balls on the on‐task behavior and academic performance of elementary students diagnosed with Attention Deficit Hyperactivity Disorder. An alternating treatments design was implemented with 4 students from the 3rd and 4th grades comparing therapy ball seating to traditional classroom chairs. No effect of the therapy balls was found, although students preferred sitting on the therapy balls. Teachers reported that the therapy balls were difficult to use and did not find them particularly effective.
Simultaneous determination and method validation of difenoconazole, propiconazole and pyraclostrobin in pepper and soil by LC–MS/MS in field trial samples from three provinces, China
Authors: Wu Sizhuo , Zhang Haizhen , Zheng Kunming , Meng Banghua , Wang Fei , Cui Ying , Zeng Song , Zhang Kankan , Hu Deyu 
Published: July 2017

AbstractA liquid chromatography–electrospray ionization tandem mass spectrometry method was developed for simple and accurate detection of the fungicides difenoconazole, propiconazole and pyraclostrobin in peppers and soil. Three fungicides residues were extracted from samples by acetonitrile and cleaned up by dispersive solid‐phase extraction before instrumental analysis. The accuracy and precision of the method were evaluated by conducting an intra‐ and inter‐day recovery experiment. The limits of quantification and detection of difenoconazole, propiconazole and pyraclostrobin in pepper and soil were 0.005 and 0.0015 mg/kg, respectively. The recoveries were investigated by spiking pepper and soil at three levels, and were found to be in the ranges 79.62–103.15% for difenoconazole, 85.94–103.35% for propiconazole and 80.14–97.69% for pyraclostrobin, with relative standard deviations <6.5%. Field experiments were conducted in three locations in China. The half‐lives of difenoconazole, propiconazole and pyraclostrobin were 5.3–11.5 days in peppers and 6.1–32.5 days in soil. At harvest, pepper samples were found to contain difenoconazole, propiconazole and pyraclostrobin well below the maximum residue limits of European Union at the interval of 21 days after last application following the recommended dosage.
Capitalizing on Scientific Advances to Improve Access to and Quality of Children's Mental Health Care
Authors: Garland Ann F. , Lebensohn‐Chialvo Florencia , Hall Kristopher G. , Cameron Erika R.N. 
Published: July 2017

AbstractThe majority of mental health problems begin in childhood or adolescence. The potential benefits of early identification and treatment of such problems are well established, and models of effective mental health interventions for children have proliferated in recent decades. However, barriers in access to care and challenges in assuring delivery of high‐quality care significantly limit the public health impact of services for children and families. Specifically, the majority of children who need mental health care do not receive it, and when children are in care, many do not receive interventions that are most likely to have the greatest positive impact. A commitment to social justice requires significant improvement in access to care and quality of care to maximize human potential.The purpose of this manuscript is to highlight promising scientific advances in the development of effective mental health services for children and families, as well as the vexing challenges of actually delivering these services to those most in need. Key challenges to be discussed include disparities in access to care and quality of care, including race/ethnic disparities and complexities of navigating the multi‐sector mental health service system for children, and difficulties in implementing effective intervention models more consistently in community care. The authors will propose practice and policy reform recommendations to address these challenges. Copyright © 2017 John Wiley & Sons, Ltd.
Development of a thiol‐ene based screening platform for enzyme immobilization demonstrated using horseradish peroxidase
Authors: Hoffmann Christian , Pinelo Manuel , Woodley John M. , Daugaard Anders E. 
Published: July 2017

Efficient immobilization of enzymes on support surfaces requires an exact match between the surface chemistry and the specific enzyme. A successful match would normally be identified through time consuming screening of conventional resins in multiple experiments testing individual immobilization strategies. In this study we present a versatile strategy that largely expands the number of possible surface functionalities for enzyme immobilization in a single, generic platform. The combination of many individual surface chemistries and thus immobilization methods in one modular system permits faster and more efficient screening, which we believe will result in a higher chance of discovery of optimal surface/enzyme interactions.The proposed system consists of a thiol‐functional microplate prepared through fast photochemical curing of an off‐stoichiometric thiol‐ene (OSTE) mixture. Surface functionalization by thiol‐ene chemistry (TEC) resulted in the formation of a functional monolayer in each well, whereas, polymer surface grafts were introduced through surface chain transfer free radical polymerization (SCT‐FRP). Enzyme immobilization on the modified surfaces was evaluated by using a rhodamine labeled horseradish peroxidase (Rho‐HRP) as a model enzyme, and the amount of immobilized enzyme was qualitatively assessed by fluorescence intensity (FI) measurements. Subsequently, Rho‐HRP activity was measured directly on the surface. The broad range of utilized surface chemistries permits direct correlation of enzymatic activity to the surface functionality and improves the determination of promising enzyme‐surface candidates. The results underline the high potential of this system as a screening platform for synergistic immobilization of enzymes onto thiol‐ene polymer surfaces. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1267–1277, 2017
Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock
Authors: Bragg Jack T. , D'Ambrosio Hannah K. , Smith Timothy J. , Gorka Caroline A. , Khan Faraz A. , Rose Joshua T. , Rouff Andrew J. , Fu Terence S. , Bisnett Brittany J. , Boyce Michael , Khetan Sudhir , Paulick Margot G. 
Published: July 2017

AbstractTrehalose is a disaccharide produced by many organisms to better enable them to survive environmental stresses, including heat, cold, desiccation, and reactive oxygen species. Mammalian cells do not naturally biosynthesize trehalose; however, when introduced into mammalian cells, trehalose provides protection from damage associated with freezing and drying. One of the major difficulties in using trehalose as a cellular protectant for mammalian cells is the delivery of this disaccharide into the intracellular environment; mammalian cell membranes are impermeable to the hydrophilic sugar trehalose. A panel of cell‐permeable trehalose analogues, in which the hydrophilic hydroxyl groups of trehalose are masked as esters, have been synthesized and the ability of these analogues to load trehalose into mammalian cells has been evaluated. Two of these analogues deliver millimolar concentrations of free trehalose into a variety of mammalian cells. Critically, Jurkat cells incubated with these analogues show improved survival after heat shock, relative to untreated Jurkat cells. The method reported herein thus paves the way for the use of esterified analogues of trehalose as a facile means to deliver high concentrations of trehalose into mammalian cells for use as a cellular protectant.
Late lumen enlargement induced by drug coated balloon in the patient with PTFE‐covered stent restenosis
Authors: Warisawa Takayuki , Naganuma Toru , Nakamura Sunao 
Published: July 2017

AbstractWe report a case of percutaneous coronary intervention with drug coated balloon (DCB) for the in‐stent restenosis of polytetrafluoroethylene‐covered stent. One year follow‐up angiography was excellent and in‐stent lumen enlargement compared with the postprocedure and 6‐months follow‐up was demonstrated by optical coherent tomography. This case suggested the utility of DCB as a therapeutic option for covered‐stent restenosis.
Clinical outcomes of balloon angioplasty alone versus nitinol stent implantation in patients with small femoropopliteal artery disease: Observations from the Retrospective Multicenter Analysis for Femoropopliteal Stenting (REAL‐FP)
Authors: Kamioka Norihiko , Soga Yoshimitsu , Kuramitsu Shoichi , Iida Osamu , Hirano Keisuke , Suzuki Kenji , Kawasaki Daizo , Yamaoka Terutoshi , Suematsu Nobuhiro , Shintani Yoshiaki , Miyashita Yusuke , Takahashi Hiroki , Tsuchiya Taketsugu , Shinozaki Norihiko , Okazaki Shinya , Ando Kenji 
Published: July 2017

AbstractObjectivesWe sought to assess whether balloon angioplasty (BA) alone for small femoropopliteal disease improved the outcome following endovascular therapy as compared with stent implantation.BackgroundThe optimal strategy of endovascular therapy for small vessel arteries in femoropopliteal disease remains unclear.MethodsWe performed a multicenter retrospective analysis of 337 consecutive patients (371 limbs) with femoropopliteal arteries 4.0 mm or less in diameter and 150 mm or less in length.ResultsCumulative 3‐year incidence of primary patency was significantly higher in the BA group than in the stent group (53.8% vs. 34.2%,P =0.002). While assisted‐primary patency and freedom from any major adverse limb events were also significantly higher in the BA group than in the stent group (70.9% vs. 44.2%,P <0.001 and 60.6% vs. 36.4%,P =0.001, respectively), secondary patency did not significantly differ between the two groups (86.9% vs. 86.9%,P =0.67). Predictors of restenosis were diabetes mellitus (hazard ratio [HR], 1.61; 95% confidence interval [CI], 1.14–2.31;P =0.01), no administration of cilostazol (HR, 1.50; 95% CI, 1.07–2.13;P =0.02), stent implantation (HR, 1.68; 95% CI, 1.15–2.41;P =0.01), and lesion length >75.0 mm(HR, 2.09; 95% CI, 1.50–2.92;P <0.001).ConclusionsLesions in small (<4.0 mm diameter) FP vessels demonstrated better primary patency at 3 years when successfully treated with balloon angioplasty alone as opposed to routine or bailout stenting. This difference was especially pronounced for lesions 75 to 150 mm in length.
Robotic‐assisted percutaneous coronary intervention
Authors: Mangels Daniel R. , Giri Jay , Hirshfeld John , Wilensky Robert L. 
Published: July 2017

AbstractPerformance of percutaneous coronary intervention (PCI) is associated with several occupational hazards including radiation exposure and musculoskeletal injury. Current methods to mitigate these risks range from suspended radiation suits to adjustable lead‐lined glass shields. Robotic‐assisted PCI is a novel approach to PCI that utilizes remote‐controlled technology to manipulate catheters thereby significantly reducing radiation exposure to the operator and catheterization laboratory staff. Although limited, current evidence indicates that robotic‐assisted PCI is associated with a high technical success rate and may have additional advantages over conventional PCI, such as a decreased incidence of geographical miss. However, as the technology is nascent, further studies including larger, randomized controlled trials are needed to expand on the long‐term clinical and safety outcomes.
Flower‐like NiO with a Hierarchical and Mesoporous Structure for Supercapacitors
Authors: Yin Shi , Wu Yongqiang , Xiong Qinqin , Qin Haiying , Chi Hong Zhong 
Published: July 2017

AbstractHierarchical porous nickel oxide (NiO) has been synthesized through an ethanol‐based hydrothermal method followed by a sintering process. The effects of hydrothermal duration on morphology, crystalline structure, and electrochemical performance are studied. With the prolongation of hydrothermal duration, the as‐prepared NiOs appear in the form of scattered nanoflakes, then flower‐like porous balls, and then solid microballs. In this period, poly‐crystallization and re‐crystallization are observed successively. It seems 120 minutes is suitable to form hierarchical NiO, 2 μm mesoporous balls composed of nanoflakes in all directions. The duration shows significant influence on charge‐storage characteristics including reversibility, capacitance, and cyclic stability. The sample exhibits 678.4 F/g at 1 A/g discharge current density and maintains 94.8 % retention after 5000 cycles, suggesting a great prospect of the hierarchical NiO to be used as an electrode material for supercapacitors.
N/S Co‐Doped 3 D Porous Carbon Nanosheet Networks Enhancing Anode Performance of Sodium‐Ion Batteries
Authors: Zou Lei , Lai Yanqing , Hu Hongxing , Wang Mengran , Zhang Kai , Zhang Peng , Fang Jing , Li Jie 
Published: July 2017

AbstractA facile and scalable method is realized for the in situ synthesis of N/S co‐doped 3 D porous carbon nanosheet networks (NSPCNNs) as anode materials for sodium‐ion batteries. During the synthesis, NaCl is used as a template to prepare porous carbon nanosheet networks. In the resultant architecture, the unique 3 D porous architecture ensures a large specific surface area and fast diffusion paths of both electrons and ions. In addition, the import of N/S produces abundant defects, increased interlayer spacings, more active sites, and high electronic conductivity. The obtained products deliver a high specific capacity and excellent long‐term cycling performance, specifically, a capacity of 336.2 mA h g−1 at 0.05 A g−1, remaining as large as 214.9 mA h g−1 after 2000 charge/discharge cycles at 0.5 A g−1. This material has great prospects for future applications of scalable, low‐cost, and environmentally friendly sodium‐ion batteries.
Mesoporous Tin‐Based Oxide Nanospheres/Reduced Graphene Composites as Advanced Anodes for Lithium‐Ion Half/Full Cells and Sodium‐Ion Batteries
Authors: He Yanyan , Li Aihua , Dong Caifu , Li Chuanchuan , Xu Liqiang 
Published: July 2017

AbstractThe large volume variations of tin‐based oxides hinder their extensive application in the field of lithium‐ion batteries (LIBs). In this study, structure design, hybrid fabrication, and carbon‐coating approaches have been simultaneously adopted to address these shortcomings. To this end, uniform mesoporous NiO/SnO2@rGO, Ni‐Sn oxide@rGO, and SnO2@rGO nanosphere composites have been selectively fabricated. Among them, the obtained NiO/SnO2@rGO composite exhibited a high capacity of 800 mAh g−1 at 1000 mA g−1 after 400 cycles. The electrochemical mechanism of NiO/SnO2 as an anode for LIBs has been preliminarily investigated by ex situ XRD pattern analysis. Furthermore, an NiO/SnO2@rGO‐LiCoO2 lithium‐ion full cell showed a high capacity of 467.8 mAh g−1 at 500 mA g−1 after 100 cycles. Notably, the NiO/SnO2@rGO composite also showed good performance when investigated as an anode for sodium‐ion batteries (SIBs). It is believed that the unique mesoporous nanospherical framework, synergistic effects between the various components, and uniform rGO wrapping of NiO/SnO2 shorten the Li+ ion diffusion pathways, maintain sufficient contact between the active material and the electrolyte, mitigate volume changes, and finally improve the electrical conductivity of the electrode.
Assessing Guest‐Molecule Diffusion in Heterogeneous Powder Samples of Metal–Organic Frameworks through Pulsed‐Field‐Gradient (PFG) NMR Spectroscopy
Authors: Thoma Roland , Kärger Jörg , de Sousa Amadeu Nader , Nießing Sandra , Janiak Christoph 
Published: July 2017

AbstractInvestigation of guest diffusion in porous metal–organic frameworks (MOFs) is of major importance, because many porosity‐related properties of MOFs are influenced by diffusion effects. The diffusion of dimethyl sulfoxide (DMSO) in the MOF MIL‐53‐NH2(Al) was investigated through pulsed‐field‐gradient (PFG) NMR spectroscopy. The microporous material was synthesized in small crystallites (under 500 nm), which agglomerated in a large range of particle sizes (from hundreds of nanometers to tens of micrometers), giving a morphologically very heterogeneous sample. No special agglomeration pattern could be observed, which makes a PFG NMR investigation very challenging, yet it represents a realistic situation for the diffusion of guest molecules in porous materials. We were able to distinguish between two diffusion regimes existing in parallel with each other over the total range from 15 to 200 ms of observation times as accessible in the experiments: In the large crystal agglomerates (diameters above 20 μm), guest movement was found to be subdiffusive, with a time exponent
=0.8 (rather than one as for normal diffusion). Guest diffusion in the remaining, smaller host particles followed the pattern of normal diffusion within a bed of spheres of impenetrable external surfaces, with a size distribution in good agreement with that of the material under study. Diffusion in a rather complex system could thus be referred to a two‐region model with new potentials for application to systems of intricate topology.
A Ligand‐Based NMR Screening Approach for the Identification and Characterization of Inhibitors and Promoters of Amyloid Peptide Aggregation
Authors: Dalvit Claudio , Santi Sara , Neier Reinhard 
Published: July 2017

AbstractOver the years a significant amount of effort has been put into the development of rapid and reliable methods to monitor the aggregation dynamics of the β1–42 amyloid peptide in real time. We present an alternative approach based on a suitable reporter or spy molecule and three different NMR experiments: WaterLOGSY, 1H selective T1 filter, and 19F T2 filter, for monitoring the initial self‐aggregation process kinetics of the β1–42 amyloid peptide and identifying molecules that retard or accelerate the self‐aggregation process. Although the proposed method is not a high‐throughput assay, it avoids problems associated with interference events that are sometimes observed in fluorescence‐based assays.
Recent Research Advances in Selective Matrix Metalloproteinase‐13 Inhibitors as Anti‐Osteoarthritis Agents
Authors: Xie Xin‐Wen , Wan Ren‐Zhong , Liu Zhao‐Peng 
Published: July 2017

AbstractMatrix metalloproteinase‐13 (MMP‐13) plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). The subtle differences between the S1′ loop of MMP‐13 and that of other MMPs offer a structural base for the design of selective MMP‐13 inhibitors to mitigate the unperceived risk associated with inhibiting other MMP isoforms. In this review, we summarize zinc‐binding and non‐zinc‐binding selective MMP‐13 inhibitors. The zinc‐binding MMP‐13 inhibitors contain a small set of zinc‐binding groups (ZBGs), including hydroxamic acid, pyrimidinetrione, reversed hydroxamic acid and hydantoin, carboxylic acid, 1,2,4,‐triazole, and 1,2,4,‐triazolone. The non‐zinc‐binding MMP‐13 inhibitors have different structural scaffolds, including diphenyl ethers, biaryls (aryltetrazoliums, arylfurans, pyrazole‐indoles), pyrimidines, and aryl/cycloalkyl‐fused pyrimidines. This review provides a systematic overview of recent developments in MMP‐13 inhibitors for the treatment of OA, with emphasis on their enzyme inhibitory potency, selectivity, and biological activities, and highlights the various binding modes of typical inhibitors with MMP‐13.
Dimethinium Heteroaromatic Salts as Building Blocks for Dual‐Fluorescence Intracellular Probes
Authors: Bříza Tomáš , Králová Jarmila , Rimpelová Silvie , Havlík Martin , Kaplánek Robert , Kejík Zdeněk , Reddy Bhupendra , Záruba Kamil , Ruml Tomáš , Mikula Ivan , Martásek Pavel , Král Vladimír 
Published: July 2017

AbstractA series of fluorescent probes based on 2‐β‐anilidovinyl‐N‐alkyl‐heteroaromatic salts was prepared. The selective intracellular localization of these probes in mitochondria and lysosomes was demonstrated. Remarkably, some of the probes exhibit unusual dichromic behavior, whereby, in just one step, the salts can be visualized in mitochondria and lysosomes at fluorescence emission wavelengths distinct from each other (dual emitters).
C−H Carboxylation of Aromatic Compounds through CO2 Fixation
Authors: Luo Junfei , Larrosa Igor 
Published: July 2017

AbstractCarbon dioxide (CO2) represents the most abundant and accessible carbon source on Earth. Thus the ability to transform CO2 into valuable commodity chemicals through the construction of C−C bonds is an invaluable strategy. Carboxylic acids and derivatives, the main products obtained by carboxylation of carbon nucleophiles by reaction of CO2, have wide application in pharmaceuticals and advanced materials. Among the variety of carboxylation methods currently available, the direct carboxylation of C−H bonds with CO2 has attracted much attention owing to advantages from a step‐ and atom‐economical point of view. In particular, the prevalence of (hetero)aromatic carboxylic acids and derivatives among biologically active compounds has led to significant interest in the development of methods for their direct carboxylation from CO2. Herein, the latest achievements in the area of direct C−H carboxylation of (hetero)aromatic compounds with CO2 will be discussed.
The double edge to parasite escape: invasive host is less infected but more infectable
Authors: Keogh Carolyn L. , Miura Osamu , Nishimura Tomohiro , Byers James E. 
Published: July 2017

AbstractNonnative species that escape their native‐range parasites may benefit not only from reduced infection pathology, but also from relaxed selection on costly immune defenses, promoting reallocation of resources toward growth or reproduction. However, benefits accruing from a reduction in defense could come at the cost of increased infection susceptibility. We conducted common garden studies of the shore crab Hemigrapsus sanguineus from highly parasitized native (Japan) populations and largely parasite‐free invasive (USA) populations to test for differences in susceptibility to infection by native‐range rhizocephalan parasites, and to explore differences in host resource allocation. Nonnative individuals showed at least 1.8 times greater susceptibility to infection than their native counterparts, and had reduced standing metabolic rates, suggesting that less of their energy was spent on physiological self‐maintenance. Our results support an indirect advantage to parasite escape via the relaxation of costly physiological defenses. However, this advantage comes at the cost of heightened susceptibility, a trade‐off of parasite escape that is seldom considered.