bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative effectiveness of prostate cancer screening between the ages of 55 and 69 years followed by active surveillance
Authors: de Carvalho Tiago M. , Heijnsdijk Eveline A. M. , de Koning Harry J. 
Published: December 2017

BACKGROUNDBecause of the recent grade C draft recommendation by the US Preventive Services Task Force (USPSTF) for prostate cancer screening between the ages of 55 and 69 years, there is a need to determine whether this could be cost‐effective in a US population setting.METHODSThis study used a microsimulation model of screening and active surveillance (AS), based on data from the European Randomized Study of Screening for Prostate Cancer and the Surveillance, Epidemiology, and End Results Program, for the natural history of prostate cancer and Johns Hopkins AS cohort data to inform the probabilities of referral to treatment during AS. A cohort of 10 million men, based on US life tables, was simulated. The lifetime costs and effects of screening between the ages of 55 and 69 years with different screening frequencies and AS protocols were projected, and their cost‐effectiveness was determined.RESULTSQuadrennial screening between the ages of 55 and 69 years (55, 59, 63, and 67 years) with AS for men with low‐risk cancers (ie, those with a Gleason score of 6 or lower) and yearly biopsies or triennial biopsies resulted in an incremental cost per quality‐adjusted life‐year (QALY) of $51,918 or $69,380, respectively. Most policies in which screening was followed by immediate treatment were dominated. In most sensitivity analyses, this study found a policy with which the cost per QALY remained below $100,000.CONCLUSIONSProstate‐specific antigen–based prostate cancer screening in the United States between the ages of 55 and 69 years, as recommended by the USPSTF, may be cost‐effective at a $100,000 threshold but only with a quadrennial screening frequency and with AS offered to all low‐risk men. Cancer 2018;124:507‐13. © 2017 American Cancer Society.
Dopamine drives left‐hemispheric lateralization of neural networks during human speech
Authors: Fuertinger Stefan , Zinn Joel C. , Sharan Ashwini D. , Hamzei‐Sichani Farid , Simonyan Kristina 
Published: December 2017

AbstractAlthough the concept of left‐hemispheric lateralization of neural processes during speech production has been known since the times of Broca, its physiological underpinnings still remain elusive. We sought to assess the modulatory influences of a major neurotransmitter, dopamine, on hemispheric lateralization during real‐life speaking using a multimodal analysis of functional MRI, intracranial EEG recordings, and large‐scale neural population simulations based on diffusion‐weighted MRI. We demonstrate that speech‐induced phasic dopamine release into the dorsal striatum and speech motor cortex exerts direct modulation of neuronal activity in these regions and drives left‐hemispheric lateralization of speech production network. Dopamine‐induced lateralization of functional activity and networks during speaking is not dependent on lateralization of structural nigro‐striatal and nigro‐motocortical pathways. Our findings provide the first mechanistic explanation for left‐hemispheric lateralization of human speech that is due to left‐lateralized dopaminergic modulation of brain activity and functional networks.
Tuning the Color Temperature of White‐Light‐Emitting Electrochemical Cells by Laser‐Scanning Perovskite‐Nanocrystal Color Conversion Layers
Authors: Wu Wen‐Kuang , Wang Cheng‐Ming , Chan Ming‐Che , Lien Jiun‐Yi , Su Yong‐Ming , Sarma Monima , Yang Zu‐Po , Su Hai‐Ching , Wong Ken‐Tsung , Wang Sue‐Lein 
Published: December 2017

AbstractThe development of white‐light‐emitting electrochemical cells (LECs) has attracted great attention owing to their numerous advantages. Recently, perovskite materials have also shown many outstanding optoelectronic properties in light absorption and emission, and hence they are suitable for serving as the color conversion layers (CCLs) in solid‐state white‐light‐emitting diodes (LEDs). Here, white LECs were fabricated by integrating non‐doped blue‐green LECs with CCLs made of a single composition of perovskite nanocrystal (NCs). Moreover, the correlated color temperatures (CCTs) of the white LECs can be tuned by modifying the optical properties of the perovskite NCs, in the same way as so as the color conversion properties of CCLs are tuned, through laser scan. By controlling the laser power, scanning number, and duty cycle of the scanned grating patterns on perovskite‐NC CCLs, the CCTs of the white LECs can be tuned from 2502 K to nearly 4300 K. Since this method is much different from that used with conventional CCLs, which use multiple compositions of perovskite NCs to produce white light, the inherent anion‐exchange issue of perovskite NCs can be avoided.
Both canopy and understory traits act as response–effect traits in fire‐managed forests
Authors: Refsland Tyler K. , Fraterrigo Jennifer M. 
Published: December 2017

AbstractCommunity‐level shifts in the distributions of plant functional traits associated with environmental change are expected to influence ecosystem functioning. However, few studies have identified traits that both respond to environmental change and affect ecosystem properties, thus limiting potential to scale the effects of environmental change through the community level. We measured canopy and understory plant functional traits, characterizing the most abundant functional trait value (community‐weighted mean; CWM) and the functional diversity (FD), across a soil resource gradient in fire‐managed mixed‐deciduous forests to determine how traits both respond to a disturbance‐resource gradient and affect stocks of active and stable soil organic carbon (SOC) fractions. We expected that understory traits would respond mainly to fire and canopy traits would respond mainly to soil resources. We further hypothesized that fire and resource conditions affect SOC stocks (1) through mass‐ratio, by influencing trait abundance; (2) through non‐additive effects, by influencing the FD of plant communities; or (3) directly, through either combustion or environmental controls on SOC stocks. Understory traits responded to soil resource conditions and fire, whereas only canopy CWM leaf dry matter content (LDMC) varied with resource conditions; no canopy traits varied with fire. Among the response traits, canopy CWM LDMC and diversity in the maximum height of the understory were related to SOC stocks, suggesting they play dual roles as response and effect traits. SOC stocks were primarily associated with mass‐ratio effects from canopy leaf traits and secondarily with non‐additive effects from the canopy and understory. There were also strong, fraction‐dependent patterns in SOC stocks with fire disturbance. Repeatedly burned forests characterized by resource conservative traits (i.e., high canopy CWM LDMC) had a higher relative proportion of active SOC, whereas unburned forests characterized by resource acquisitive traits (i.e., high canopy CWM leaf nitrogen content) had a higher relative proportion of stable SOC. Our results suggest that canopy community‐aggregated leaf traits and diversity in understory size traits can act as both response and effect traits in disturbed forests. Predicting forest SOC stocks using a response–effect trait framework will thus require knowledge of both canopy and understory trait distributions, as well as disturbance history.
Catalytic Activity of Microbially‐formed Palladium Nanoparticles
Authors: Yang Sarah A. , Nordmeier Akira , Chidambaram Dev 
Published: December 2017

AbstractThe catalytic behavior of microbially‐formed palladium nanoparticles using Clostridium pasteurianum BC1 is reported. To our knowledge, this is the first study that evaluates the electrochemical catalytic activity of microbially‐formed palladium nanoparticles. Pd nanoparticles formed using immobilized microbes were found to exhibit an average mass activity of 177 mA mg−1 which was almost twice the activity of the abiotically formed controls (94 mA mg−1). The results of this study aim to support the use of nanoparticles formed using facile and environmentally‐friendly microbial synthesis methods as a suitable alternative as opposed to standard physical and chemical synthesis methods.
Determination of Benzocaine and Tricaine in Fish Fillets Using BIA with Amperometric Detection
Authors: de Lima Rafael Machado Felix , de Oliveira Silva Michele Dorcília , Felix Fabiana Silva , Angnes Lucio , dos Santos Wallans Torres Pio , Saczk Adelir Aparecida 
Published: December 2017

AbstractA system based on batch injection analysis (BIA) associated with amperometric detection at screen‐printed carbon electrode was used for the precise and rapid quantification of the anesthetics compounds benzocaine and tricaine in fresh fish fillets. Along this study, the best conditions for the BIA‐amperometry system were stablished for the rapid determination of these compounds. The results obtained demonstrate that the proposed method is an interesting alternative to the chromatographic methods, once it allows to perform rapid analysis (more than 300 injections per hour) with low limits of detection (3.02×10−8 mol L−1 for benzocaine and 3.19×10−8 mol L−1 for tricaine), using just 80 μL of sample for each analysis. Furthermore, it was possible to obtain high repeatability for both compounds analyzed, demonstrating good performance. The simple sample preparation developed in this study drastically reduced the amount of fat in the fish extract, favoring precision, as shown by the results of the recovery studies of both anesthetics contained in the fish samples (values above 99 % for both analytes).
Power Generation versus Conventional Potentiostatic Operation of Prussian Blue Based (Bio)Sensors
Authors: Komkova Maria A. , Karyakina Elena E. , Karyakin Arkady A. 
Published: December 2017

AbstractWe report on Prussian Blue based (bio)sensors displaying advantageous analytical performance characteristics when operated both in conventional three‐electrode regime powered by potentiostat and in power generation mode. ‘Self‐powered’ sensors are commonly aimed to produce sufficient energy for signalling and, thus, being energetically autonomous. In order to generate maximum energy output, the electrodes with high potential difference are preferable. In contrast, we propose the systems with the lowest potential difference between the working and the counter electrodes. Short‐circuiting the Prussian Blue modified working and the Ag|AgCl reference electrode, working electrode potential is adjusted to 0.00 V without potentiostat. The efficiency of the (bio)sensors in power generation mode is achieved due to high catalytic activity of Prussian Blue at 0.00 V versus Ag|AgCl reference. Here we discuss the benefits of the Prussian Blue based (bio)sensors operated through power generation in a short‐circuit regime without potentiostat, including an order of magnitude decreased noise and simplified readout. The multimodality of the sensors would provide their versatile functionality for the electroanalysis and elaboration of miniature highly sensitive wearable devices.
Nano‐species Release System Activated by Enzyme‐based XOR Logic Gate
Authors: Filipov Yaroslav , Gamella Maria , Katz Evgeny 
Published: December 2017

AbstractAn enzyme‐based XOR logic gate was realized at interface of an alginate‐modified electrode. The biocatalytic production of H2O2 inside the alginate film was controlled by logically processed input signals. The in situ generated H2O2 was decomposed to yield free radicals in a Fenton‐type reaction catalyzed by iron cations, which were present in the alginate film as cross‐linkers stabilizing the hydrogel. The produced free radicals (•OH, •OOH) resulted in decomposition/dissolution of the alginate film removing it from the electrode surface and stimulating release process of magnetic nanoparticles (MNPs) functionalized with a fluorescent dye and entrapped in the alginate film. The release of the MNPs was analyzed by following fluorescence appearing in the solution. The release process followed the logic features of the XOR gate. The present system is the first realization of the enzyme‐based XOR gate functionally integrated with the downstream actuation process in the form of the signal‐stimulated release.
Direct determination of amino acids in brewery worts produced by different processes by capillary zone electrophoresis
Authors: Corrêa de Carvalho Renata , Rocha dos Santos Mathias Thiago , Duarte Pereira Netto Annibal , Ferreira de Carvalho Marques Flávia 
Published: December 2017

AbstractThe direct and simultaneous determination of cysteine, histidine, phenylalanine, lysine, tryptophan and arginine in brewery worts by capillary zone electrophoresis (CZE) was applied to evaluate the effects of temperature control and protease supplementation during mashing on the changes of these amino acids (AAs) wort composition. A cation exchange resin was used for AAs extraction from wort samples prior to CZE determination. The separation was achieved using a 50 mmol/L phosphate buffer at pH 12.5, containing 0.4 mmol/L cetyltrimethylammonium bromide (CTAB), as background electrolyte (BGE) solution; −20 kV; 20°C and hydrodynamic injection time of 15 s, at 50 mbar. Recovery evaluation using worts led to values between 83.1 and 96.2%, demonstrating the method feasibility, which was successfully applied in the quantification of AAs in wort samples. This study showed that temperature control and addition of exogenous proteases in the mashing may increase the AAs concentration in wort, improving the final product quality (beer). The present method is a good alternative for monitoring specific AAs in worts and their determination can allow the brewing process optimization.
Rigorous modeling of gas permeation behavior in facilitated transport membranes (FTMs); evaluation of carrier saturation effects and double‐reaction mechanism
Authors: Ebadi Amooghin Abtin , Moftakhari Sharifzadeh Mohammad Mehdi , Zamani Pedram Mona 
Published: December 2017

AbstractIn this work, a general model for the gas permeation behavior of facilitated transport membranes (FTMs) has been developed. The importance of developing a clearer understanding of FTM permeation behavior by introducing a detailed two‐dimensional FTM model was demonstrated. This model accounts for the effects of partial pressure on permeance by considering the carrier saturation‐state phenomenon and reaction‐diffusion portions in FTMs. The model is based on a first order double‐step reaction mechanism with respect to the role of the concentration of zwitterion ions in the facilitated transport of CO2. It is shown here that the individual values of reaction constant rates and diffusion coefficients of components in the chemical reaction, which belong to the FTM condition, have been determined by the FTMs’ permeability and were not guessed or calculated. Overall, this work provides a method for the more reliable use of models to understand and design of FTMs, and to better comprehend the large and growing body of experimental data on these kinds of membranes. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd.
Migration and accumulation of crude oil in Upper Triassic tight sand reservoirs on the southwest margin of Ordos Basin, Central China: A case study of the Honghe Oilfield
Authors: Jia Jingkun , Yin Wei , Qiu Nansheng , Wang Guangli , Ma Liyuan , Liu Yuchen , Liu Nian 
Published: December 2017

The Upper Triassic tight sand oil in the Ordos Basin has gradually become a focus of research; however, compared to the centre of the basin, studies on the margin have been relatively weak. In this study, an integrated approach involving oil–source correlation, charge history, and pressure evolution is used to investigate the migration characteristics of each stage and to establish a migration and accumulation process model of the tight sand oil in the Yanchang Formation of Honghe Oilfield in combination with reservoir densification process. The results show that, based on the fluid inclusion analysis and authigenic illite K–Ar dating technique in combination with burial and thermal modellings, the accumulation periods were 145–130, 120–90, and 90–80 Ma, which corresponds to the Cretaceous. According to the relative content of C30‐diahopane and drimane series compounds, the crude oil from Chang 8(T3ch8) and Chang 9(T3ch9) both originated from the oil shale of Chang 7(T3ch7) in the Upper Triassic Yanchang Formation. The migration characteristics and directions are comprehensively analyzed using the maturity parameters and key elements. In the early stage of the Early Cretaceous, with east‐dipping strata, crude oil migrated from northeast to southwest. During the late Early Cretaceous, the middle‐late Yanshanian movement promoted the development of strike‐slip faults and fractures, and the oil migrated vertically downwards along them. Tectonic inversion changed the strata dip direction to west‐dipping, and lateral migration was also changed to two directions of southwest and northeast. After the Late Cretaceous, the migration dynamics weakened due to strata uplift and cessation of hydrocarbon generation. Only slight adjustments to the crude oil occurred during the Himalayan movement; therefore, the current distribution pattern of the tight sand oil is still affected primarily by the stage of late Early Cretaceous. The migration and accumulation model of the Upper Triassic in the Honghe Oilfield, Ordos Basin, provides a theoretical basis for further exploration and is of general applicability to tight sand reservoirs in the margins of various basins.
Why does repatriate career success vary? An empirical investigation from both traditional and protean career perspectives
Authors: Breitenmoser Anika , Bader Benjamin , Berg Nicola 
Published: December 2017

AbstractTo increase the long‐term benefits of global mobility for multinational corporations, international assignments and intraorganizational careers must be strategically integrated. However, systematic research on former expatriates' career success upon returning to their home organization remains scarce. Hence, this study transfers findings from the career literature to the repatriation context to identify the predictors of objective and subjective repatriate career success. Integrating traditional and protean career theory, we investigate data from 295 repatriates of publicly listed German organizations. Applying partial least squares structural equation modeling, we reveal that objective career success upon repatriation is affected by international assignment characteristics with human capital implications, repatriation support provided by the organization, and the individual's self‐directed career management. Objective career success, organizational repatriation support, and self‐directed career management further affect subjective career success in terms of career satisfaction. Hence, substantiating an impact of both traditional and protean career factors on repatriate careers, our results lay the groundwork for repatriation strategies that combine organizational and individual career management. In this way, multinational corporations can go beyond managing repatriate elites to make better use of all globally experienced employees.
Profiling and characterization of microRNAs responding to sodium butyrate treatment in A549 cells
Authors: Xiao Xiaoqiang , Cao Yingjie , Chen Haoyu 
Published: December 2017

AbstractButyrate inhibits growth of lung cancer. However, the molecular mechanism is still unclear. Here we profiled miRNAs that responded to sodium butyrate(NaB) stimulation in A549 cells, a non‐small cell lung cancer cell line, using microarray. We found 33 up‐regulated microRNAs and 22 down‐regulated microRNAs (log2 ≥1.5 folds, P‐value <0.05). The expression of miR‐3935, miR‐574‐3p, and miR‐494‐3p was confirmed by realtime qPCR. Then,we explored their potential targets of miR‐3935 and miR‐494‐3p using long noncoding RNA(LncRNA) microarray. Using cell expressing negative microRNA as control, we found 103 up‐regulated transcripts (including 69 mRNA and 34 LncRNA), and 36 down‐regulated transcripts (including 34 mRNAs and 2 LncRNA), in miR‐3935 over‐expressing A549 cells; 128 up‐regulated transcripts (121 mRNAs, 7 LncRNAs) and 180 down‐regulated transcripts (169 mRNAs, 11 LncRNAs) in mir‐494‐3p, respectively (log2 Fold change ≥ 1 & P < 0.05). The expression of RNF115, NTRK3, SLC39A6, and USB1 was confirmed with qPCR. Immunoblotting was adopted to detect RNF115 expression in miR‐3935 overexpressed A549 cells. Then, using a luciferase reporter assay system, we found that miR‐3935 overexpression significantly decreased 3UTR of RNF115 mediated luciferase expression .In addition, we also observed that the proliferation and migration of A549 cells was obviously prevented by miR‐3935 overexpression. Finally, we showed miR‐3935 and miR‐494‐3p induced interferon stimulated gene 15(ISG15) expression through activating its promoter transcription. Together, we profiled microRNAs that responded to NaB treatment and characterized their biological functions in A549 cells. Those results provided new clue for the future treatment of non small cell lung cancer.
NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer
Authors: Tang Laiqin , Long Zhiguo , Zhao Na , Feng Guangjia , Guo Xianzhi , Yu Minghua 
Published: December 2017

AbstractTrastuzumab, a humanized antibody targeting human epidermal growth factor receptor 2 (HER2), exhibits remarkable therapeutic efficacy against HER2‐positive gastric cancer. Acquired resistance to trastuzumab remains a barrier to patient survival and the mechanisms underlying this are still not well understood. The normal epithelial cell‐specific‐1 (NES1) gene, also named as KLK10, is recognized as a potential therapeutic target for reversing trastuzumab resistance. The aim of this study was to explore the potential role of KLK10 in trastuzumab resistance (TR) gastric cancer cells. We found that KLK10 was significantly upregulated in trastuzumab‐resistant cell lines, SGC7901‐TR and BGC‐823‐TR. In addition, down regulation of KLK10 reversed the resistance in trastuzumab resistant cells. Overexpression of KLK10 induced trastuzumab resistance, and activated the PI3K/AKT signaling pathway, while downregulation of KLK10 presented the opposite effects. Moreover, when the PI3K/AKT signaling pathway was inhibited, the effect of KLK10 on resistance was diminished. Furthermore, combination of trastuzumab and PI3K/AKT inhibitor XL147 effectively inhibited tumor growth in KLK10‐overexpressing xenografts. Taken together, our findings show that KLK10 promotes trastuzumab resistance, at least in part, through the PI3K/AKT signaling pathway, suggesting that KLK10 is a potentially target to overcome trastuzumab resistance, and the combination might overcome trastuzumab resistance in KLK10‐overexpressed gastric cancer patients.