bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and implementation of a trapeziectomy rehabilitation protocol
Authors: Henstridge Lucy 
Published: March 2017

Introduction The purpose of this study was to evaluate a newly developed trapeziectomy rehabilitation protocol. Variability in trapeziectomy rehabilitation protocols and the arrival of new surgeons in our hospital required a uniform protocol. Methods Fifty hands in 44 patients (32 women/12 men) were immobilised for 4 weeks in a plaster cast after a trapeziectomy. A carpometacarpal splint immediately followed for 2 weeks, taken off for exercises and self-care. Patients were assessed preoperatively and at 3, 6 and 12 months using: a pain visual analogue scale (VAS), grip, tip pinch and lateral pinch strength, goniometry, the Modified Kapandji Index (MKI), the Quick Disabilities of the Arm, Shoulder and Hand questionnaire (Q-DASH, Dutch version) and the Short Form 36 (SF-36, Dutch version). At 3, 6 and 12 months, patient’s satisfaction with the operation was rated on a satisfaction VAS. Results The correlation between pain and patient satisfaction was significant ( ρ = −0.80). VAS pain improved from a median of 75 mm preoperatively to 20 mm at 12 months ( p < 0.01). The Q-DASH improved from a median of 48 preoperatively to 20 at 12 months ( p < 0.01). Median grip, tip pinch and lateral pinch strength increased at 12 months by 19%, 8% and 24%, respectively from the baseline measurement. Conclusions Patients participating in a standardised protocol after trapeziectomy with 4 weeks immobilisation demonstrated improvements in pain, Q-DASH, grip strength, tip pinch and lateral pinch grip. They were satisfied with the results. Further research into the optimal immobilisation time after trapeziectomy surgery is needed.
Shifting Landscapes: The Impact of Centralized and Decentralized Nursing Station Models on the Efficiency of Care
Authors: Fay Lindsey , Carll-White Allison , Schadler Aric , Isaacs Kathy B. , Real Kevin 
Published: March 2017

Objective: The focus of this research was to analyze the impact of decentralized and centralized hospital design layouts on the delivery of efficient care and the resultant level of caregiver satisfaction. Background: An interdisciplinary team conducted a multiphased pre- and postoccupancy evaluation of a cardiovascular service line in an academic hospital that moved from a centralized to decentralized model. This study examined the impact of walkability, room usage, allocation of time, and visibility to better understand efficiency in the care environment. Method: A mixed-methods data collection approach was utilized, which included pedometer measurements of staff walking distances, room usage data, time studies in patient rooms and nurses’ stations, visibility counts, and staff questionnaires yielding qualitative and quantitative results. Results: Overall, the data comparing the centralized and decentralized models yielded mixed results. This study’s centralized design was rated significantly higher in its ability to support teamwork and efficient patient care with decreased staff walking distances. The decentralized unit design was found to positively influence proximity to patients in a larger design footprint and contribute to increased visits to and time spent in patient rooms. Conclusion: Among the factors contributing to caregiver efficiency and satisfaction are nursing station design, an integrated team approach, and the overall physical layout of the space on walkability, allocation of caregiver time, and visibility. However, unit design alone does not solely impact efficiency, suggesting that designers must consider the broader implications of a culture of care and processes.
Outcome of Asymptomatic Osteochondritis Dissecans of the Capitellum in Adolescent Baseball Players
Authors: Matsuura Tetsuya , Iwame Toshiyuki , Suzue Naoto , Sairyo Koichi 
Published: March 2017

Objectives: Osteochondritis dissecans (OCD) of the capitellum is a well-recognized cause of elbow pain and disability in adolescent baseball players. OCD is classified into three different stages based on AP radiographs of the elbow in 45°flexion. Stage I was characterized by radiolucent areas. In stage II, nondisplaced fragments were present. Loose bodies and sclerotic change indicated stage III. Matsuura et al performed the conservative treatment on 101 patients with stage I or II lesions. Conservative treatment consisted of discontinuation of heavy use of the elbow for at least 6 months. Of 101 patients, 84 were diagnosed as stage I, with a mean age of 11.3 years and 17 were in stage II, with a mean age of 13.9 years. Of the 84 patients in stage I, healing was observed in 90.5%. In stage II, the incidence of healing decreased to 52.9%. Mean period required for healing was 14.9 months in stage I and 12.3 months in stage II. These results suggest that conservative treatment is recommended for the early stage lesions. However, little is known about the outcome of conservative treatment for asymptomatic OCD patients. The purpose of this study was to investigate 2year follow-up outcome of asymptomatic OCD in adolescent baseball players. Methods: We retrospectively reviewed 33 baseball players aged 9-12 years (mean, 11.3 years) with asymptomatic OCD. There were 23 stage I lesions and 10 stage II lesions. We recommended the conservative treatment including stop throwing to all the players. Sixteen players (48.5%) agreed to our advice. The remaining 17 players did not follow the authors’ advice. Twelve players (36.4%) changed position or throwing side and 5 players (15.1%) did not change throwing level. Two years later, subjects were evaluated clinically and radiographically. Radiological outcome was divided into 3 types, complete repair, incomplete repair, and failure. Results: Stop throwing produced complete repair in 93.7%, incomplete repair in 6.3%, and none of the failure. Changing position or throwing side produced complete repair in 41.7%, incomplete repair in 25%, and failure in 33.3%. Not changing throwing level produced complete repair in 20%, none of incomplete repair, and failure in 80% ( Table 1 ). Players with complete or incomplete repair had not any symptom at the follow-up. On the other hand, all the players with failure had symptom such as pain and/or catching. Six of 8 players (75%) with symptom needed operation. [Table: see text] Conclusion: Even in the asymptomatic early stage OCD, it is desirable to stop throwing until the healing is observed.
How I treat autoimmune hemolytic anemia
Authors: Go Ronald S. , Winters Jeffrey L. , Kay Neil E. 
Published: March 2017

AbstractAutoimmune hemolytic anemia (AIHA) is an uncommon entity that presents diagnostic, prognostic, and therapeutic dilemmas despite being a well-recognized entity for over 150 years. This is because of significant differences in the rates of hemolysis and associated diseases and because there is considerable clinical heterogeneity. In addition, there is a lack of clinical trials required to refine and update standardized and evidence-based therapeutic approaches. To aid the clinician in AIHA management, we present four vignettes that represent and highlight distinct clinical presentations with separate diagnostic and therapeutic pathways that we use in our clinical practice setting. We also review the parameters present in diagnostic testing that allow for prognostic insight and present algorithms for both diagnosis and treatment of the AIHA patient in diverse situations. This is done in the hope that this review may offer guidance in regard to personalized therapy recommendations. A section is included for the diagnosis of suspected AIHA with negative test results, a relatively infrequent but challenging situation, in order to assist in the overall evaluation spectrum for these patients.
Video scene identification and classification for user-tailored QoE in GEO satellites
Authors: Koutsakis Polychronis , Spanou Irene , Lazaris Aggelos 
Published: March 2017

AbstractSatellite networks offer an efficient alternative where no terrestrial networks are available, and can offer a cost effective means of transferring data. Numerous proposals have addressed the problem of resource allocation in geostationary (GEO) satellites, and have been evaluated via various performance metrics related to user Quality of Service (QoS). However, ensuring that on average the users’ QoS requirements are satisfied does not guarantee the satisfaction of their individual Quality of Experience (QoE) requirements, especially in the case of bursty video users. This paper proposes the use of video scene identification and classification for traffic modeling at the scene level in order to improve resource allocation and user QoE in GEO satellite networks. The proposed call admission control and medium access control framework makes decisions based on available bandwidth, long-term and short-term user satisfaction and the revenue that the provider may gain.
Neutrophil, quo vadis?
Authors: Jablonska Jadwiga , Granot Zvi 
Published: March 2017

AbstractNeutrophils were traditionally considered to be a homogeneous population of terminally differentiated cells with very defined roles in inflammation and fighting infections. However, recent advances in neutrophil research challenge this limited view and demonstrate that neutrophils are highly versatile, play different roles in various pathologic scenarios, and are heterogeneous. With this, it is becoming clear that one term—“neutrophil”—is too general, and more precise nomenclature is urgently required. In this mini review, we discuss the knowns and unknowns in neutrophil terminology and highlight the critical questions that should be addressed for the establishment of clear neutrophil nomenclature.
Ten-Year Progression-Free and Overall Survival in Patients With Unresectable or Metastatic GI Stromal Tumors: Long-Term Analysis of the European Organisation for Research and Treatment of Cancer, Italian Sarcoma Group, and Australasian Gastrointestinal Trials Group Intergroup Phase III Randomized Trial on Imatinib at Two Dose Levels
Authors: Casali Paolo G. , Zalcberg John , Le Cesne Axel , Reichardt Peter , Blay Jean-Yves , Lindner Lars H. , Judson Ian R. , Schöffski Patrick , Leyvraz Serge , Italiano Antoine , Grünwald Viktor , Pousa Antonio Lopez , Kotasek Dusan , Sleijfer Stefan , Kerst Jan M. , Rutkowski Piotr , Fumagalli Elena , Hogendoorn Pancras , Litière Saskia , Marreaud Sandrine , van der Graaf Winette , Gronchi Alessandro , Verweij Jaap ,   on behalf of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group, Italian Sarcoma Group, and Australasian Gastrointestinal Trials Group
Published: March 2017

Purpose To report on the long-term results of a randomized trial comparing a standard dose (400 mg/d) versus a higher dose (800 mg/d) of imatinib in patients with metastatic or locally advanced GI stromal tumors (GISTs). Patients and Methods Eligible patients with advanced CD117-positive GIST from 56 institutions in 13 countries were randomly assigned to receive either imatinib 400 mg or 800 mg daily. Patients on the 400-mg arm were allowed to cross over to 800 mg upon progression. Results Between February 2001 and February 2002, 946 patients were accrued. Median age was 60 years (range, 18 to 91 years). Median follow-up time was 10.9 years. Median progression-free survival times were 1.7 and 2.0 years in the 400- and 800-mg arms, respectively (hazard ratio, 0.91; P = .18), and median overall survival time was 3.9 years in both treatment arms. The estimated 10-year progression-free survival rates were 9.5% and 9.2% for the 400- and 800-mg arms, respectively, and the estimated 10-year overall survival rates were 19.4% and 21.5%, respectively. At multivariable analysis, age (< 60 years), performance status (0 v ≥ 1), size of the largest lesion (smaller), and KIT mutation (exon 11) were significant prognostic factors for the probability of surviving beyond 10 years. Conclusion This trial was carried out on a worldwide intergroup basis, at the beginning of the learning curve of the use of imatinib, in a large population of patients with advanced GIST. With a long follow-up, 6% of patients are long-term progression free and 13% are survivors. Among clinical prognostic factors, only performance status, KIT mutation, and size of largest lesion predicted long-term outcome, likely pointing to a lower burden of disease. Genomic and/or immune profiling could help understand long-term survivorship. Addressing secondary resistance remains a therapeutic challenge.
Factors associated with awareness about syphilis and gonorrhoea among women in Bangladesh
Authors: Hossain Mosharaf , Islam Rafiqul , Sarkar Aziza Sultana Rosy 
Published: March 2017

Background: Currently, syphilis and gonorrhoea among women is a topic great concernin Bangladesh. To date, little is known in the existing literature regarding its prevalence, and the current level of syphilis and gonorrhoea awareness among women with regard to prevention is inadequate. This research aims to identify factors associated with awareness of syphilis and gonorrhoea among women in Bangladesh. Methods: Data were collected from women by the Bangladesh Demographic and Health Survey (BDHS) 2011 as a cross-sectional study. The seven divisions surveyed were Dhaka, Rajshahi, Rangpur, Chittagong, Barisal, Khulna and Sylhet. The number of women in the seven divisions totalled 17,842. The chi-squared test and a logistic regression model were used to determine the social-demographic factors associated with awareness about syphilis and gonorrhoea among women in Bangladesh. Results: The rate of awareness about syphilis and gonorrhoea among women in Bangladesh was 13.3% and 15.7%, respectively. The chi-squared test and logistic analysis demonstrated that there is a significant association between the awareness of syphilis and gonorrhoea with the respondents’ age, location of the respondents’ house, educational level of the respondent, socioeconomic status, geographic region, and respondents that listened to the radio and watched TV. Conclusions: There is an essential need to expand the learning and teaching program in Bangladesh regarding syphilis and gonorrhoea, mainly among younger women (<25 years) in all topographical and rural areas. Advertising drives and mass broadcasting programs can be used to increase knowledge within societies, particularly among women. In addition, the low awareness of syphilis and gonorrhoea indicates that prevention interventions are required among women.
Optimal Markdown Pricing and Inventory Allocation for Retail Chains with Inventory Dependent Demand
Authors: Smith Stephen A. , Agrawal Narendra 
Published: March 2017

We analyze how inventory dependence of demand affects the optimal pricing and distribution of inventory across multiple retail locations. Our problem formulation corresponds to the typical markdown management decisions in a retail chain. The solution methodology determines the optimal combinations of three important operational levers—pricing, inventory allocation, and store consolidation. Inventory dependence causes the optimal price trajectory to decrease over time as the current on-hand inventory decreases. The optimal inventory allocation shifts more inventory to the larger stores as the inventory effect becomes stronger. Solution methodologies are also developed for the case of optimal constant prices, which leads to the same optimal inventory allocations. If all stores have the same seasonal variations and the inventory is allocated optimally, then all stores have identical price trajectories. Optimal consolidation of the inventory to a subset of the stores is also determined. Consolidation of inventory to a subset of stores can be beneficial even when there are no fixed costs of stocking a store. Using some typical parameter values for retail items, our calculations show that significant benefits can result from taking the inventory effect into account in pricing, inventory allocation, and store consolidation decisions. The online appendix is available at https://doi.org/10.1287/msom.2016.0609 .
Innovation Outcomes in a Distributed Organization: Intrafirm Mobility and Access to Resources
Authors: Choudhury Prithwiraj 
Published: March 2017

Prior research has established a relation between intrafirm mobility and innovation outcomes at distributed organizations. The literature has also uniformly agreed on the mechanism underlying this relationship: the sharing of tacit knowledge and recombination of ideas that occurs because of intrafirm mobility. But a second mechanism may also be at work: intrafirm mobility might help distant employees secure access to resources for their innovative projects. Using unique data on travel, employment, and patenting for 1,315 inventors at the Indian research and development (R&D) center of a Fortune 50 multinational, I find that intrafirm mobility in the form of short-duration business trips from a distant R&D location to headquarters is positively related to higher subsequent patenting at the individual level. I also find mobility immediately prior to meetings at which R&D funds are most likely to be disbursed to be related to higher subsequent patenting. This study sheds new light on how intrafirm mobility and possible face-to-face interactions with those who allocate resources might affect innovation outcomes and the matching of resources to individuals within a distributed organization.The online appendix is available at https://doi.org/10.1287/orsc.2017.1121 .
Early performance-based and patient-reported outcomes of a contemporary taper fit bone-conserving short stem femoral component in total hip arthroplasty
Authors: Hossain F. , Konan S. , Volpin A. , Haddad F. S. 
Published: March 2017

AimsThe aim of this study was to compare early functional and health related quality of life outcomes (HRQoL) in patients who have undergone total hip arthroplasty (THA) using a bone conserving short stem femoral component and those in whom a conventional length uncemented component was used. Outcome was assessed using a validated performance based outcome instrument as well as patient reported outcome measures (PROMs).Patients and MethodsWe prospectively analysed 33 patients whose THA involved a contemporary proximally porous coated tapered short stem femoral component and 53 patients with a standard conventional femoral component, at a minimum follow-up of two years. The mean follow-up was 31.4 months (24 to 39). Patients with poor proximal femoral bone quality were excluded. The mean age of the patients was 66.6 years (59 to 77) and the mean body mass index was 30.2 kg/m2(24.1 to 41.0). Outcome was assessed using the Oxford Hip Score (OHS) and the University College Hospital (UCH) hip score which is a validated performance based instrument. HRQoL was assessed using the EuroQol 5D (EQ-5D).ResultsThere were no major peri-operative complications. There was no difference in the mean post-operative OHS, EQ-5D or function subscale of the UCH hip scores between the two groups. The mean pre-operative OHS and EQ-5D scores improved significantly (all p < 0.001). The mean functional component of the UCH hip score at final follow-up was 42.5 and 40.6 in the short stem and conventional stem groups, respectively. There was no statistically significant difference between the groups (p = 0.42). A total of seven patients (21.2%) in the short stem group and nine (16.98%) in the conventional group achieved a ceiling effect using the OHS; none did using the function subscale of the UCH hip score.ConclusionThe proximally porous coated tapered short stem femoral component achieves comparable short-term functional outcomes when compared with a conventional longer stem uncemented femoral component when THA is undertaken in patients with good bone quality. Cite this article: Bone Joint J 2017;99-B(4 Supple B):49–55.
Quality of bone repair in ovariectomized rats with bone lesions treated with phytotherapic and homeopathic Arnica montana
Authors: Silva Edmundo , Pereira Vanessa Fernandes , Vasconcellos Luana Marotta Reis , Oliveira Felipe Eduardo , Brandão Adriana Aigotti Haberbeck 
Published: March 2017

Objective: National and international data show that in the next years the elder population tends to have an exponential increase becoming to be significantly higher than other ages. Among the frequent diseases in the elderly, osteoporosis is a disease that decreases bone mass and deteriorates bone structure causing fragility and a high risk of fracture. This study aimed to evaluate the effect of phytotherapic and homeopathic Arnica montana on bone repair quality and its possible use in the treatment of bone fracture in patients with osteoporosis. Material and Methods: This experimental study was performed in Wistar adult female rats divided in 4 groups according to the following treatments: ovariectomized treated with homeopathic A. montana 6CH (OVZ 6CH); ovariectomized treated with phytotherapic A. montana (OVZ TM); ovariectomized with placebo (OVZ PL) and rats with sham surgery and placebo (Sham PL). In a period of 45 days after ovariectomy or sham surgery, all animals got a monocortical lesion. They were euthanized after 6, 12, 18 and 28 days and had the tibiae removed to evaluate dimensions and bone repair by radiographic density, biomechanical test and scanning electronic microscopy (SEM). Data were analyzed by ANOVA and TUKEY tests (p < 0.05). Results: Results showed that treatment with Arnica 6CH was better than Arnica TM considering bone resistance and bone repair quality. Conclusion: This study concluded that treatment with homeopathic A. montana was more efficient than with phytotherapic Arnica in bone regeneration in rats with osteoporosis.KeywordsArnica montana; Homeopathy; Osteoporosis; Phytotherapy; Radiographic bone density.
Procalcitonin is not a marker of sterile inflammation in dogs after ovariohysterectomy
Authors: Gürbüz Hasan Oğuz , Ulutaş Pınar Alkım 
Published: March 2017

Abstract
CRP and WBC are the most widely used markers of inflammation in veterinary clinical diagnosis. Also, PCT is a specific APP marker of bacterial diseases in humans. This study evaluated the levels of PCT, CRP and WBC during postoperative monitoring of bitches undergoing ovariohysterectomy. Thirteen adult clinically healthy female crossbreed dogs aged between 7-24 months were used in the study. Ovariohysterectomy was performed via medial laparotomy using routine procedures. Blood samples were collected from the cephalic vein at 1, 4 and 7 days after surgery (post-op period). Mean serum concentration of PCT, CRP and WBC levels were increased after the surgery. CRP concentrations and WBC counts were increased significantly (p<0.001) on the first day after the operation and decreased to basal values. However, the PCT rise was not significant. CRP and WBC levels increased rapidly and decreased to normal values in dogs with ovariohysterectomy. CRP and WBC may be of help to determine the possible postoperative complications. Besides, aseptic surgical trauma did not affect PCT levels in dogs. Future studies are needed on canine PCT response focusing on specific bacterial infections.
Treatment of Patients with Risk Factors: Compliance and Adherence
Authors: Accetto Rok , Korenčan Simona , Radenković Sonja , Milenković Jelena 
Published: March 2017

Summary
Hypertension and dyslipidemias represent important risk factors for the occurrence of cardiovascular diseases which have a high mortality rate. Although we know how to treat both, the success rate remains low. More than half of patients need at least two antihypertensive agents to achieve target blood pressure. Also, dyslipidemia frequently coexists and thus the burden of life-long pill taking is high and the adherence is low. We suggest treating both conditions simultaneously in a fixed combination. This would increase patients' adherence and compliance to therapy and therefore provide a more successful management of both conditions.