bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons From New York State’s Preparedness Efforts for Ebola
Authors: Zucker Howard A. , Whalen Dennis , Raske Kenneth E. 
Published: November 2016

AbstractPreparing an entire health care system for an outbreak of a deadly infectious disease is an intensive, time-consuming process that requires collaboration and cooperation at all levels. New York achieved this goal when it became apparent that the Ebola outbreak in West Africa had the potential to spread beyond the 3 most heavily impacted countries. We discuss New York’s work with health care associations to prepare the multiple tiers of the state’s health care system to successfully transport, identify, diagnose, and treat the disease, while also handling clinical, consequence, and communications management of the outbreak. The massive statewide efforts laid the groundwork for managing future outbreaks and emergencies and provide a model for other states to follow. (Disaster Med Public Health Preparedness. 2017;11:383–388).
HOW TO INSULT AND COMPLIMENT A TESTIFIER
Authors: Malcolm Finlay 
Published: November 2016

ABSTRACTDo we insult or slight a speaker when we reject her testimony? Do we compliment or commend her when we accept her testimony? This paper argues that the answer to both of these questions is “yes”, but only in some instances, since these respective insults and compliments track the reasons a hearer has for rejecting or accepting testimony. When disbelieving a speaker, a hearer may insult her because she judges the speaker to be either incompetent as a knower or insincere as a teller. By outlining the predominant reasons we have for rejecting testimony, I show how not every instance of rejecting testimony embodies this negative evaluation of the speaker. By contrast, testimonial compliments are fewer in number, and are not constitutive of “everyday” testimonial exchanges, since speakers who are competent as knowers and sincere as tellers are merely behaving correctly in accordance with the norms of testifying. Nevertheless, deferring to an authority on belief can be complimentary to that speaker if by doing so we judge her to have some mastery in a particular domain. This suggests an asymmetry between rejecting and accepting testimony. Testimonial insults and compliments also have important moral applications, particularly regarding epistemic injustice and therapeutic trust.
Radiocarbon Analysis on the New AARAMS 1MV Tandetron
Authors: Olsen Jesper , Tikhomirov Dmitry , Grosen Claus , Heinemeier Jan , Klein Matthias 
Published: November 2016

AbstractWe report here on the radiocarbon performance on the AARAMS HVE 1MV Tandetron. 14C analysis is carried out in charge state 2+. We have avoided Li interference by appropriate settings of the high-energy electrostatic analyzer and the 30° second high-energy magnet. The 14C machine background is determined using unprocessed graphite, which yielded 58,650±2032 14C yr determined as the average and standard deviation of four measurements. International standards, which are used to monitor the long-term performance of the 14C measurements, agree with the reported consensus values.
Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children
Authors: García-Solís Pablo , Reyes-Bastidas Marissa , Flores Karla , García Olga P. , Rosado Jorge L. , Méndez-Villa Lorena , Garcia-G Carlota , García-Gutiérrez David , Kuri-García Aarón , Hernández-Montiel Hebert L. , Soriano-Leon Ofelia , Villagrán-Herrera Maria Elena , Solis-Sainz Juan C. 
Published: November 2016

AbstractChildhood overweight and obesity are worldwide public health problems and risk factors for chronic diseases. The presence of SNP in several genes has been associated with the presence of obesity. A total of 580 children (8–13 years old) from Queretaro, Mexico, participated in this cross-sectional study, which evaluated the associations of rs9939609 (fat mass obesity-associated (FTO)), rs17782313 (melanocortin 4 receptor (MC4R)) and rs6548238 (transmembrane protein 18 (TMEM18)) SNP with obesity and metabolic risk factors. Overweight and obesity prevalence was 19·8 and 19·1 %, respectively. FTO, MC4R and TMEM18 risk allele frequency was 17, 9·8 and 89·5 %, respectively. A significant association between FTO homozygous and MC4R heterozygous risk alleles and obesity was found (OR 3·9; 95 % CI 1·46, 10·22, and OR 2·1; 95 % CI 1·22, 3·71; respectively). The FTO heterozygous subjects showed higher systolic and diastolic blood pressures, compared with the homozygous for the ancestral allele subjects. These results remain significant after considering adiposity as a covariate. The FTO and MC4R genotypes were not significantly associated with total cholesterol, HDL-cholesterol and insulin concentration. No association was found between TMEM18 risk allele and obesity and/or metabolic alterations. Our results show that, in addition to a higher BMI, there is also an association of the risk genotype with blood pressure in the presence of the FTO risk genotype. The possible presence of a risk genotype in obese children must be considered to offer a more comprehensive therapeutic approach in order to delay and/or prevent the development of chronic diseases.
Genotypic and environmental variability of yield from seven different crops in Croatian official variety trials and comparison with on-farm trends
Authors: ZORIĆ M. , GUNJAČA J. , ŠIMIĆ D. 
Published: November 2016

SUMMARYAssessment of the value for cultivation and use (VCU) of a new cultivar, essential for its official registration, is done through a series of trials carried out over a 2–3-year period and across many locations. In a set of multi-environment VCU trials, evaluation of new genotypes can be a laborious task due to the presence of genotype by environment interactions, which can hide their true genetic value. In an attempt to reveal the true genetic value of new cultivars, a good starting point is investigation of the importance of various genetic and environmental sources of variation, which can be done by estimating relative magnitude of corresponding variance components within the mixed model framework.Genotype × location × year (G × L × Y) data set for seven crops taken from the 10-year period 2001–10 was used in the present study to estimate the variance components for main effects and their interactions in Croatian VCU trials. Depending on the crop, the most important and least important components were Y or LY, and L or GL, respectively. Genotypic effect was relatively small, ranging from 2·1 to 13·4% of the total variation. The current results are comparable with the relative sizes of the variance components obtained in studies from four- to sixfold larger countries, indicating that the environments within Croatia, if sufficiently widely sampled, can provide as extreme cultivar responses as a geographically more dispersed set of VCU trials. The gap range in different crops is much wider (30–60%) than in Western Europe (up to 30%), but it remained constant over the 10-year period.
Central European parasitic flatworms of the Cyclocoelidae Stossich, 1902 (Trematoda: Plagiorchiida): molecular and comparative morphological analysis suggests the reclassification of Cyclocoelum obscurum (Leidy, 1887) into the Harrahium Witenberg, 1926
Authors: SITKO JILJÍ , BIZOS JIŘÍ , HENEBERG PETR 
Published: November 2016

SUMMARYCyclocoelidae Stossich, 1902 are medium-sized to large digenean bird parasites. Although these parasites bear few visible autapomorphic signs, and their diagnostic characters are unstable in response to the pressure applied during preparation, the numerous hitherto suggested re-classifications within the family have not been supported by any molecular analysis. We analyse here cyclocoelids found during the extensive examination of central European birds performed from 1962 to 2016, provide comparative measurements, host spectra, prevalence and intensity, and provide and analyse sequences of four DNA loci of five of the cyclocoelid species. Cyclocoleum Brandes, 1892 appears paraphyletic; thus we suggest the re-classification of Cyclocoleum obscurum (Leidy, 1887) as Harrahium obscurum (Leidy, 1887) Sitko and Heneberg comb. n. Molecular phylogenetics questioned also the validity of Cyclocoelinae Stossich, 1902 and Hyptiasminae Dollfus, 1948, which formed a single clade, whereas Allopyge Johnston, 1913, Prohyptiasmus Witenberg, 1923 and Morishitium Witenberg, 1928 formed another clade. Haematotrephinae Dollfus, 1948 are newly characterized as having a pretesticular or intertesticular ovary that forms a triangle with the testes. Analyses of non-European genera of the Cyclocoelidae and an examination of the position of families within Echinostomata La Rue, 1926 are needed.
Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls
Authors: Lange E. H. , Nerland S. , Jørgensen K. N. , Mørch-Johnsen L. , Nesvåg R. , Hartberg C. B. , Haukvik U. K. , Osnes K. , Melle I. , Andreassen O. A. , Agartz I. 
Published: November 2016

BackgroundExcessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association.Method1.5 T structural magnetic resonance images were acquired of 609 alcohol-using participants (165 schizophrenia patients, 172 bipolar disorder patients, 272 healthy controls), mean (s.d.) age 34.2 (9.9) years, 52% men. Past year alcohol use was assessed with the Alcohol Use Disorder Identification Test – Consumption part (AUDIT-C). General linear models were used to investigate associations between AUDIT-C score and cortical thickness, surface area, and total brain and subcortical volumes.ResultsIncreasing AUDIT-C score was linearly associated with thinner cortex in medial and dorsolateral frontal and parieto-occipital regions, and with larger left lateral ventricle volume. There was no significant interaction between AUDIT-C score and diagnostic group. The findings remained significant after controlling for substance use disorders, antipsychotic medication and illness severity.ConclusionThe results show a dose-dependent relationship between alcohol use and thinner cortex and ventricular expansion. The findings are present also at lower levels of alcohol consumption and do not differ between schizophrenia or bipolar disorder patients compared to healthy controls. Our results do not support previous findings of increased vulnerability for alcohol-related brain damage in severe mental illness.
Efficacy of sequential nephron blockade with intravenous chlorothiazide to promote diuresis in cardiac intensive care infants
Authors: Moffett Brady S. , Tsang Rocky , Kennedy Curt , Bronicki Ron A. , Akcan-Arikan Ayse , Checchia Paul A. 
Published: November 2016

AbstractBackgroundSequential nephron blockade using intravenous chlorothiazide is often used to enhance urine output in patients with inadequate response to loop diuretics. A few data exist to support this practice in critically ill infants.MethodsWe included 100 consecutive patients <1 year of age who were administered intravenous chlorothiazide while receiving furosemide therapy in the cardiac ICU in our study. The primary end point was change in urine output 24 hours after chlorothiazide administration, and patients were considered to be responders if an increase in urine output of 0.5 ml/kg/hour was documented. Data on demographic, clinical, fluid intake/output, and furosemide and chlorothiazide dosing were collected. Multivariable regression analyses were performed to determine variables significant for increase in urine output after chlorothiazide administration.ResultsThe study population was 48% male, with a mean weight of 4.9±1.8 kg, and 69% had undergone previous cardiovascular surgery. Intravenous chlorothiazide was initiated at 89 days (interquartile range 20–127 days) of life at a dose of 4.6±2.7 mg/kg/day (maximum 12 mg/kg/day). Baseline estimated creatinine clearance was 83±42 ml/minute/1.73 m2. Furosemide dose before chlorothiazide administration was 2.8±1.4 mg/kg/day and 3.3±1.5 mg/kg/day after administration. A total of 43% of patients were categorised as responders, and increase in furosemide dose was the only variable significant for increase in urine output on multivariable analysis (p<0.05). No graphical trends were noted for change in urine output and dose of chlorothiazide.ConclusionsSequential nephron blockade with intravenous chlorothiazide was not consistently associated with improved urine output in critically ill infants.
Photomotility of polymers
Authors: Wie Jeong Jae , Shankar M. Ravi , White Timothy J. 
Published: November 2016

AbstractLight is distinguished as a contactless energy source for microscale devices as it can be directed from remote distances, rapidly turned on or off, spatially modulated across length scales, polarized, or varied in intensity. Motivated in part by these nascent properties of light, transducing photonic stimuli into macroscopic deformation of materials systems has been examined in the last half-century. Here we report photoinduced motion (photomotility) in monolithic polymer films prepared from azobenzene-functionalized liquid crystalline polymer networks (azo-LCNs). Leveraging the twisted-nematic orientation, irradiation with broad spectrum ultraviolet–visible light (320–500 nm) transforms the films from flat sheets to spiral ribbons, which subsequently translate large distances with continuous irradiation on an arbitrary surface. The motion results from a complex interplay of photochemistry and mechanics. We demonstrate directional control, as well as climbing.
Hydrogenated monolayer graphene with reversible and tunable wide band gap and its field-effect transistor
Authors: Son Jangyup , Lee Soogil , Kim Sang Jin , Park Byung Cheol , Lee Han-Koo , Kim Sanghoon , Kim Jae Hoon , Hong Byung Hee , Hong Jongill 
Published: November 2016

AbstractGraphene is currently at the forefront of cutting-edge science and technology due to exceptional electronic, optical, mechanical, and thermal properties. However, the absence of a sizeable band gap in graphene has been a major obstacle for application. To open and control a band gap in functionalized graphene, several gapping strategies have been developed. In particular, hydrogen plasma treatment has triggered a great scientific interest, because it has been known to be an efficient way to modify the surface of single-layered graphene and to apply for standard wafer-scale fabrication. Here we show a monolayer chemical-vapour-deposited graphene hydrogenated by indirect hydrogen plasma without structural defect and we demonstrate that a band gap can be tuned as wide as 3.9 eV by varying hydrogen coverage. We also show a hydrogenated graphene field-effect transistor, showing that on/off ratio changes over three orders of magnitude at room temperature.
A multi-marker association method for genome-wide association studies without the need for population structure correction
Authors: Klasen Jonas R. , Barbez Elke , Meier Lukas , Meinshausen Nicolai , Bühlmann Peter , Koornneef Maarten , Busch Wolfgang , Schneeberger Korbinian 
Published: November 2016

AbstractAll common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a new GWA method, called Quantitative Trait Cluster Association Test (QTCAT), enabling simultaneous multi-marker associations while considering correlations between markers. With this, QTCAT overcomes the need for population structure correction and also reflects the polygenic nature of complex traits better than single-marker methods. Using simulated data, we show that QTCAT clearly outperforms linear mixed model approaches. Moreover, using QTCAT to reanalyse public human, mouse and Arabidopsis GWA data revealed nearly all known and some previously undetected associations. Following up on the most significant novel association in the Arabidopsis data allowed us to identify a so far unknown component of root growth.
Direct observation of confined acoustic phonon polarization branches in free-standing semiconductor nanowires
Authors: Kargar Fariborz , Debnath Bishwajit , Kakko Joona-Pekko , Säynätjoki Antti , Lipsanen Harri , Nika Denis L. , Lake Roger K. , Balandin Alexander A. 
Published: November 2016

AbstractSimilar to electron waves, the phonon states in semiconductors can undergo changes induced by external boundaries. However, despite strong scientific and practical importance, conclusive experimental evidence of confined acoustic phonon polarization branches in individual free-standing nanostructures is lacking. Here we report results of Brillouin—Mandelstam light scattering spectroscopy, which reveal multiple (up to ten) confined acoustic phonon polarization branches in GaAs nanowires with a diameter as large as 128 nm, at a length scale that exceeds the grey phonon mean-free path in this material by almost an order-of-magnitude. The dispersion modification and energy scaling with diameter in individual nanowires are in excellent agreement with theory. The phonon confinement effects result in a decrease in the phonon group velocity along the nanowire axis and changes in the phonon density of states. The obtained results can lead to more efficient nanoscale control of acoustic phonons, with benefits for nanoelectronic, thermoelectric and spintronic devices.
Product lambda-doublet ratios as an imprint of chemical reaction mechanism
Authors: Jambrina P. G. , Zanchet A. , Aldegunde J. , Brouard M. , Aoiz F. J. 
Published: November 2016

AbstractIn the last decade, the development of theoretical methods has allowed chemists to reproduce and explain almost all of the experimental data associated with elementary atom plus diatom collisions. However, there are still a few examples where theory cannot account yet for experimental results. This is the case for the preferential population of one of the Λ-doublet states produced by chemical reactions. In particular, recent measurements of the OD(2Π) product of the O(3P)+D2 reaction have shown a clear preference for the Π(A′) Λ-doublet states, in apparent contradiction with ab initio calculations, which predict a larger reactivity on the A′′ potential energy surface. Here we present a method to calculate the Λ-doublet ratio when concurrent potential energy surfaces participate in the reaction. It accounts for the experimental Λ-doublet populations via explicit consideration of the stereodynamics of the process. Furthermore, our results demonstrate that the propensity of the Π(A′) state is a consequence of the different mechanisms of the reaction on the two concurrent potential energy surfaces
In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine
Authors: Muthumani Karuppiah , Griffin Bryan D , Agarwal Sangya , Kudchodkar Sagar B , Reuschel Emma L , Choi Hyeree , Kraynyak Kimberly A , Duperret Elizabeth K , Keaton Amelia Anne , Chung Christopher , Kim Yinho K , Booth Stephanie A , Racine Trina , Yan Jian , Morrow Matthew P , Jiang Jingjing , Lee Brian , Ramos Stephanie , Broderick Kate E , Reed Charles C , Khan Amir S , Humeau Laurent , Ugen Kenneth E , Park Young K , Maslow Joel N , Sardesai Niranjan Y , Joseph Kim J , Kobinger Gary P , Weiner David B 
Published: November 2016

AbstractSignificant concerns have been raised owing to the rapid global spread of infection and disease caused by the mosquito-borne Zika virus (ZIKV). Recent studies suggest that ZIKV can also be transmitted sexually, further increasing the exposure risk for this virus. Associated with this spread is a dramatic increase in cases of microcephaly and additional congenital abnormalities in infants of ZIKV-infected mothers, as well as a rise in the occurrence of Guillain Barre’ syndrome in infected adults. Importantly, there are no licensed therapies or vaccines against ZIKV infection. In this study, we generate and evaluate the in vivo efficacy of a novel, synthetic, DNA vaccine targeting the pre-membrane+envelope proteins (prME) of ZIKV. Following initial in vitro development and evaluation studies of the plasmid construct, mice and non-human primates were immunised with this prME DNA-based immunogen through electroporation-mediated enhanced DNA delivery. Vaccinated animals were found to generate antigen-specific cellular and humoral immunity and neutralisation activity. In mice lacking receptors for interferon (IFN)-α/β (designated IFNAR−/−) immunisation with this DNA vaccine induced, following in vivo viral challenge, 100% protection against infection-associated weight loss or death in addition to preventing viral pathology in brain tissue. In addition, passive transfer of non-human primate anti-ZIKV immune serum protected IFNAR−/− mice against subsequent viral challenge. This study in NHP and in a pathogenic mouse model supports the importance of immune responses targeting prME in ZIKV infection and suggests that additional research on this vaccine approach may have relevance for ZIKV control and disease prevention in humans.
Parallel evolution of passive and active defence in land snails
Authors: Morii Yuta , Prozorova Larisa , Chiba Satoshi 
Published: November 2016

AbstractPredator-prey interactions are major processes promoting phenotypic evolution. However, it remains unclear how predation causes morphological and behavioural diversity in prey species and how it might lead to speciation. Here, we show that substantial divergence in the phenotypic traits of prey species has occurred among closely related land snails as a result of adaptation to predator attacks. This caused the divergence of defensive strategies into two alternatives: passive defence and active defence. Phenotypic traits of the subarcticKaraftohelixland snail have undergone radiation in northeast Asia, and distinctive morphotypes generally coexist in the same regions. In these land snails, we documented two alternative defence behaviours against predation by malacophagous beetles. Furthermore, the behaviours are potentially associated with differences in shell morphology. In addition, molecular phylogenetic analyses indicated that these alternative strategies against predation arose independently on the islands and on the continent suggesting that anti-predator adaptation is a major cause of phenotypic diversity in these snails. Finally, we suggest the potential speciation ofKaraftohelixsnails as a result of the divergence of defensive strategies into passive and active behaviours and the possibility of species radiation due to anti-predatory adaptations.