bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Transcriptome Analyses Reveal that Potato Spindle Tuber Viroid Triggers Genome-Wide Changes in Alternative Splicing, Inducible
trans
-Acting Activity of Phased Secondary Small Interfering RNAs, and Immune Responses
Authors: Zheng Yi , Wang Ying , Ding Biao , Fei Zhangjun 
Published: March 2017

ABSTRACT

Many pathogens express noncoding RNAs (ncRNAs) during infection processes. In the most extreme case, pathogenic ncRNAs alone (such as viroids) can infect eukaryotic organisms, leading to diseases. While a few pathogenic ncRNAs have been implicated in regulating gene expression, the functions of most pathogenic ncRNAs in host-pathogen interactions remain unclear. Here, we employ potato spindle tuber viroid (PSTVd) infecting tomato as a system to dissect host interactions with pathogenic ncRNAs, using comprehensive transcriptome analyses. We uncover various new activities in regulating gene expression during PSTVd infection, such as genome-wide alteration in alternative splicing of host protein-coding genes, enhanced guided-cleavage activities of a host microRNA, and induction of the
trans
-acting function of phased secondary small interfering RNAs. Furthermore, we reveal that PSTVd infection massively activates genes involved in plant immune responses, mainly those in the calcium-dependent protein kinase and mitogen-activated protein kinase cascades, as well as prominent genes involved in hypersensitive responses, cell wall fortification, and hormone signaling. Intriguingly, our data support a notion that plant immune systems can respond to pathogenic ncRNAs, which has broad implications for providing new opportunities for understanding the complexity of immune systems in differentiating “self” and “nonself,” as well as lay the foundation for resolving the long-standing question regarding the pathogenesis mechanisms of viroids and perhaps other infectious RNAs.

IMPORTANCE
Numerous pathogens, including viruses, express pathogenic noncoding transcripts during infection. In the most extreme case, pathogenic noncoding RNAs alone (i.e., viroids) can cause disease in plants. While some work has demonstrated that pathogenic noncoding RNAs interact with host factors for function, the biological significance of pathogenic noncoding RNAs in host-pathogen interactions remains largely unclear. Here, we apply comprehensive genome-wide analyses of plant-viroid interactions and discover several novel molecular activities underlying nuclear-replicating viroid infection processes in plants, including effects on the expression and function of host noncoding transcripts, as well as the alternative splicing of host protein-coding genes. Importantly, we show that plant immunity is activated upon infection of a nuclear-replicating viroid, which is a new concept that helps to understand viroid-based pathogenesis. Our finding has broad implications for understanding the complexity of host immune systems and the diverse functions of noncoding RNAs.
Report from the 1st International Workshop on Collaborative Modelling in MDE (COMMitMDE 2016)
Authors: Gérard Sébastien , Kolovos Dimitrios S. , Malavolta Ivano , Muccini Henry 
Published: March 2017

COMMitMDE was the 1st international workshop on Collaborative Modelling in MDE, held on the 4th of October 2016 as a satellite event of the 19th International Conference on Model Driven Engineering Languages and Systems (MoDELS 2016), St. Malo, France. The goal of the workshop was to bring together researchers and practitioners in order to investigate (i) the potential impact of collaborative software engineering methods and principles into Model-Driven Engineering (MDE) practices and (ii) how MDE methods and techniques can support collaborative software engineering activities.
The 1st COMMitMDE workshop provided a forum to discuss the state of research and practice on collaborative MDE, to create new synergies between tool vendors, researchers, and practitioners, to inform the community about the new means for collaborative MDE, and to reect on the needs and research gaps in the collaborative MDE area.
СИНДРОМ ЕМОЦІЙНОГО ВИГОРАННЯ - ОДИН ІЗ ПСИХОЛОГІЧНИХ ЧИННИКІВ НЕГАТИВНОГО ВПЛИВУ НА ЗДОРОВ’Я МЕДИЧНОЇ СЕСТРИ
Authors: Litvinyuk V. V. , Lototska O. V. 
Published: March 2017

У статті розглянуто наявність різних симптомів синдрому емоційного вигорання у медичних сестер різних клінічних закладів м. Вінниці, як одного із чинників негативного впливу на здоров’я та запропоновано заходи по його профілактиці.
НАЙБІЛЬШ ПОШИРЕНІ ТОКСИЧНІ СИНДРОМИ, ЩО ВИНИКАЮТЬ ПРИ ОТРУЄННІ ДИКОРОСЛИМИ ОТРУЙНИМИ ТА УМОВНО ЇСТІВНИМИ ГРИБАМИ
Authors: Lokay B. A. , Tsyhankova S. V. 
Published: March 2017

У статті розглянуто питання епідеміології, клініки та основних принципів лікування гострих отруєнь дикорослими грибами. Наведено дані щодо захворюваності гострими отруєннями дикорослими грибами серед пацієнтів, які перебували на лікуванні у відділенні інтенсивної терапії Комунальної установи «Міська клінічна лікарня екстреної та швидкої медичної допомоги м. Запоріжжя».
РОЛЬ МЕДИЧНОЇ СЕСТРИ У ПОДОЛАННІ ВІДЧУТТЯ САМОТНОСТІ В ПАЦІЄНТІВ ХОСПІСУ
Authors: Tomchuk T. V. , Bob A. O. 
Published: March 2017

Відчуття самотності у пацієнтів хоспісу спостерігається у 96 % хворих. Медична сестра, співпрацюючи із лікарями у хоспісах, допомагає пацієнтам долати складні наслідки самотності, шляхом надання консультацій, інформацій та підтримки.Медсестра повинна вміти розпізнати і вчасно звернути увагу на виражену самотність пацієнта. Кваліфікаційний, ефективний медсестринський догляд допомагає їм подолати відчуття самотності.
The learning curve for needle knife precut sphincterotomy revisited
Authors: Li James Weiquan , Ang Tiing Leong , Kam Jia Wen , Kwek Andrew Boon Eu , Teo Eng Kiong 
Published: March 2017

BackgroundThere is no consensus on what constitutes adequate training for needle knife precut sphincterotomy.ObjectiveThe purpose of this study was to determine the number of procedures required before effective and safe precut sphincterotomy can be achieved.MethodsThis retrospective study examined the cumulative experience of a single endoscopist from January 2006–December 2015. Precut sphincterotomy success and complication rates were analyzed as a function of number of procedures performed. Acceptable success and complication rates were defined as 85% and 10% respectively. A one‐sided binomial test was used to test success and complication rates of every 25 precut sphincterotomies performed.ResultsThe index endoscopic retrograde cholangiopancreatography was successful in 141/158 (89.2%) patients who underwent precut sphincterotomy. This increased to 148/158 (93.7%) when endoscopic retrograde cholangiopancreatography was repeated on another day. Six precut sphincterotomies were required to achieve an 85% success probability. This was maintained consistently above 85% after 13 precuts, and was significantly higher (91.2%; p  = 0.029) than 85% at the 125th precut. Bleeding and pancreatitis developed in 2/158 (1.3%) and 5/158 (3.2%). Probability of either complications remained below 5% after 50 precuts. No perforation occurred.ConclusionAt least 13 precut sphincterotomies were required to achieve a sustained success rate greater than 85%. The probability of bleeding or pancreatitis was less than 5% after 50 precut sphincterotomies.
Reticular dysgenesis: international survey on clinical presentation, transplantation, and outcome
Authors: Hoenig Manfred , Lagresle-Peyrou Chantal , Pannicke Ulrich , Notarangelo Luigi D. , Porta Fulvio , Gennery Andrew R. , Slatter Mary , Cowan Morton J. , Stepensky Polina , Al-Mousa Hamoud , Al-Zahrani Daifulah , Pai Sung-Yun , Al Herz Waleed , Gaspar Hubert B. , Veys Paul , Oshima Koichi , Imai Kohsuke , Yabe Hiromasa , Noroski Lenora M. , Wulffraat Nico M. , Sykora Karl-Walter , Soler-Palacin Pere , Muramatsu Hideki , Al Hilali Mariam , Moshous Despina , Debatin Klaus-Michael , Schuetz Catharina , Jacobsen Eva-Maria , Schulz Ansgar S. , Schwarz Klaus , Fischer Alain , Friedrich Wilhelm , Cavazzana Marina 
Published: March 2017

Key Points
Compared with other SCID entities, patients with RD have an earlier presentation with bacterial rather than opportunistic infections. Myeloablative agents before transplantation support reliable myeloid engraftment and long-term cure in patients with RD.
Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology
Authors: Hovorkova Lenka , Zaliova Marketa , Venn Nicola C. , Bleckmann Kirsten , Trkova Marie , Potuckova Eliska , Vaskova Martina , Linhartova Jana , Machova Polakova Katerina , Fronkova Eva , Muskovic Walter , Giles Jodie E. , Shaw Peter J. , Cario Gunnar , Sutton Rosemary , Stary Jan , Trka Jan , Zuna Jan 
Published: March 2017

Key Points
Combination of Ig/TCR and BCR-ABL1 genomic approach for MRD monitoring in childhood ALL reveals patients with CML-like disease. Monitoring ALL using BCR-ABL1 genomic breakpoint is feasible and enables the most specific and sensitive MRD quantification.
New directions for the dense city: Moshe Safdie in Singapore
Authors: Bischeri Cecilia , Micheli Silvia 
Published: March 2017

In 1965, Singapore declared its independence and initiated a process of modernisation aiming to erase any evidence of its colonial past. Thedevelopmentalist orientation of Singapore, as Rem Koolhaas defined it, together with the formula “displace, destroy, replace,” became the theoretical instruments used to implement the urban vision for the future city. Singapore has thus become the contemporary urban laboratory of the Asia Pacific Region and due to its limited area for construction, turned into an experimental epicentre in the field of dense dwelling. A protagonist of this experimentation has been the Israeli/Canadian architect Moshe Safdie, designer of the Integrated resort casino Marina Bay Sands (2010), an exemplary feature of Singapore’s drive for development. This paper focuses on Safdie’s theoretical work, casting light on the ideological shift from his early modern residential project Habitat‘67, built during the Expo in Montreal (Canada) in 1967, to the contemporary residential complex Sky Habitat, completed in 2015 in Singapore. While Habitat’67 represented the manifesto of Safdie’s social utopia, envisaging itself as a prototypical residential component of the future city, Sky Habitat is a private gated community, which targets an upper-class market. And yet, Safdie’s two projects, distant in time and social ideals, display comparable strategies, as the use of similar architectural solutions and the permanence of urban modern utopian principles. These strategies underpin two other projects designed recently by Safdie in China: the Golden Dream Bay in Qinhuangdao (2016) and Chongqing Chaotianmen (design phase), which propose further elaboration of Sky Habitat’s urban principles. This paper will investigate how utopian urban strategies elaborated during the Modern period and advanced and tested in the 1960s and 1970s, have become material of experimentation for new forms of living in the congested 21st century city, evolving the concept of urban density in “the city that could be”.
„Danke für eure Tipps!“
Authors: Sablotny Manfred 
Published: March 2017

Zusammenfassung
Der vorliegende Beitrag befasst sich mit den Interaktionsprozessen in einer sprachniveauübergreifenden Facebook-Gruppe im DaF-Unterricht. Ausgehend von den Konzepten des Scaffolding und der Zone der nächsten Entwicklung wurde an einer Universität in Taiwan als Ergänzung zum Präsenzunterricht eine Facebook-Gruppe für Deutschlernende unterschiedlicher Kursniveaus angelegt. Neben Form- und Bedeutungsaushandlungen im Rahmen von Korrekturen und Verbesserungsvorschlägen ließen sich Hilfestellungen und Mutzusprechungen nachweisen. Eine besondere Herausforderung für Interaktionsprozesse in der neuen Lernumgebung stellten die Bereiche Mitarbeit und Fehlerkorrektur dar. Auch im Bereich der Gruppenverwaltung und -dokumentation ergaben sich Probleme. Die vorgestellten Lösungsansätze für diese Problembereiche verweisen auf die Notwendigkeit einer regelmäßigen Anbindung an den Präsenzunterricht, eine gezielte Schulung studentischer Tutorinnen und Tutoren, die Einbindung muttersprachlicher Hilfskräfte und die vorausschauende Planung von Bearbeitungsfristen. Lernen wird in diesem Beitrag als sozialer Prozess der Interaktion, als Ko-Konstruktion von Wissen verstanden.
Die High-Performance-Plattform New STN – eine neue Recherchedimension
Authors: Bolle Babett 
Published: March 2017

Zusammenfassung
Patentinformationen spielen im Innovationsprozess eine entscheidende Rolle. Alle innovativen Unternehmen müssen, um ihr Investitionsrisiko zu minimieren und abzusichern, verlässliche Informationen zum Stand der Technik zu den Wettbewerbern und dem Marktumfeld recherchieren. Informations- Services im Patentbereich müssen daher höchsten Ansprüchen bei der Präzision und Zielgenauigkeit der Suche, ebenso wie bei der Aktualität und Vollständigkeit der Daten gerecht werden. Mit der neuen STN-Plattform hat FIZ Karlsruhe in Kooperation mit CAS (Chemical Abstract Service) eine neue Dimension bei der Informations- und Patentrecherche geöffnet. Ein intuitives Nutzerinterface für Informationsexperten, branchenführende Performance und Workflowoptimierung sind die Markenzeichen der neuen STN-Plattform. Die neue STN-Plattform wurde 2012, zunächst in einer Beta-Version, erstmals der Öffentlichkeit vorgestellt. Seit 2013 läuft die neue Plattform als Vollversion und wird kontinuierlich erweitert. Die neue STN-Plattform soll das klassische STN in Zukunft ablösen. Zurzeit werden beide STN Systeme parallel betrieben.
Für eine informationswissenschaftliche Aufwertung von Rezensionen
Authors: Brademann Jan 
Published: March 2017

ZusammenfassungDer Autor plädiert dafür, wissenschaftliche Rezensionen stärker als Gegenstand informationswissenschaftlicher Forschung und Praxis in den Blick zu nehmen. Verabschiedet man sich von der Vorstellung, dass dokumentarische Objektivität durch die Minimierung der Subjektivität des Abstracters zu erreichen sei, und begreift man (intellektuelles) Abstracting als produktiven Prozess, der wesentlich von den sozialen Regeln der scientific community bestimmt ist, so lässt sich erkennen, dass das Interesse an wissenschaftlichen Rezensionen als spezifischer Textsorte Teil eines gruppenspezifischen Informationsverhaltens ist.
Integration audiovisueller Aufzeichnungen in das Records Management einer Organisation: ein konzeptionelles Metadatenmodell
Authors: Büttner Gesa 
Published: March 2017

ZusammenfassungDieser Artikel stellt ein konzeptionelles Metadatenmodell vor, das auf Records verschiedener Medientypen anwendbar ist. Organisationen, die im Zuge ihrer Tätigkeit regelmäßig sowohl textbasierte als auch audiovisuelle Records erstellen, haben beide Medien im Sinne des Records Management zu verwalten. Dazu sind Metadaten, einschließlich der des zentralen Ordnungssystems für Records, ein Hauptwerkzeug. Inspiriert durch medienübergreifende, auf gemeinsamen Zugriff ausgerichtete Metadatenmodelle, wird ein neues Modell vorgeschlagen. Es kombiniert die hierarchische Abstraktion der existierenden Modelle mit den Prinzipien des Records Management. Das Modell kann Organisationen dabei helfen, Entscheidungen über Metadaten für ihre Records zu treffen.
Crystal structure of (E)-4,4′-(ethene-1,2-diyl)bis(3-nitrobenzoic acid) 1.5 hydrate, C16H13N2O9.5
Authors: Song Li , Hui Liu , Linxin Deng , Xiangdong Qin 
Published: March 2017

Abstract
C16H13N2O9.5, triclinic, P1̄ (no. 2), a = 7.3757(4) Å, b = 7.7827(5) Å, c = 15.2903(10) Å, α = 79.473(4)°, β = 82.927(4)°, γ = 72.069(4)°, V = 818.92(9) Å3, Z = 2, R
gt(F) = 0.0444, wR
ref(F
2) = 0.1317, T = 298 K.
Removal of radiocesium from low level radioactive effluents by hexacyanoferrate loaded synthetic zeolite: laboratory to pilot plant scale demonstration
Authors: Banerjee Dayamoy , Rao Manjula A. , Khot Shantinath A. , Pawaskar Chandrahas S. , Gangadharan Anand , Rao Shankar N. , Jain Savita , Shah Jayesh G. , Banerjee Kalyan 
Published: March 2017

Abstract
Present paper reports removal of radiocesium from low level waste using a modified sorbent (13X-CFC) prepared by in-situ precipitation of potassium copper hexacyanoferrate(II) inside the macropores of a synthetic zeolite. The Cs exchange isotherm of the sorbent is established and it found to follow Fruendlich absorption isotherm equation. It is varified that presence of hexacyanoferrate on zeolite facilitates rapid Cs uptake performance. This is further confirmed in laboratory scale column tests, wherein excellent Cs removal performance from low level waste simulant was observed even at higher flow rates (40 bed volumes per hour). The utility of the sorbent is established through successful demonstration in a pilot scale (50 L) trial with almost complete removal of 137Cs from more than 14,000 bed volumes of actual low level waste. The sorbent, owing to its low cost and excellent 137Cs removal performance, is expected to find application in treatment of very low active waste streams.
Synthesis, radiolabeling and biological evaluation of [125I]-1-[2-(benzylthio)ethyl]-4-(5-iodo-2-methoxyphenyl)piperazine as a new 5-HT1A receptor ligand
Authors: Narimani Ali , Sadeghzadeh Masoud , Kurdtabar Mehran 
Published: March 2017

Abstract
5-HT1A receptors have been implicated in the pathogenesis of a wide variety of disorders related to the serotonin receptors. WAY100635 is a well-known high affinity 5-HT1A receptor antagonist. Many 11C and 18F radiolabeled derivatives and its radioiodinated analogues have been reported as imaging agents for 5-HT1A receptors. In this regard, the synthesis, radiolabeling and biological evaluation of a new 5-HT1A receptor radioligand, [125I]-1-(2-(benzylthio)ethyl)-4-(5-iodo-2-methoxyphenyl)piperazine ([125I]-BTE-IMPP), are described. Radioiodination of this newly synthesized compound was done by the direct aromatic electrophilic substitution via Iodo-Gen method. Radiochemical yield and radiochemical purity determined by TLC and RTLC were >70% and >95%, respectively. Biodistribution studies of [125I]-BTE-IMPP in rats displayed relatively high uptake in hippocampus (Hip) and low uptake in cerebellum (Cer). The level of the radiotracer uptake was over threefold higher in hippocampus than in cerebellum at 30 min post-injection. Moreover, the brain to blood uptake ratio and the blocking studies results indicated prolonged retention of the radiotracer and relatively good specific binding to 5-HT1A receptor. These findings strongly suggest that [125I]-BTE-IMPP could be a good candidate as an in vivo marker for pharmacological study of 5-HT1A receptors in animal models.
Weitere Überlegungen zu den Voraussetzungen und Folgen des Perikleischen Bürgerrechtsgesetzes: Naturalisierung und Epigamie im Klassischen Athen
Authors: Coşkun Altay 
Published: March 2017

Summary
This study departs from the recent re-assessment of Pericles’ Citizenship Law: it made descent from two citizen parents a necessary requirement for citizenship, without allowing for any deadlines or exemptions. Behind this background, at first all traces of potential exceptions that might have been formulated in the law are considered - and rejected. However, special regulations would still have been necessary, if one posits that the assembly of the people had been used to convey either citizenship to individuals or epigamia to foreign poleis prior to the mid-5th century BC. In fact, two examples of early naturalization in Athens have been adduced in scholarly literature: those of Menon of Pharsalus and Polygnotus of Thasus. While these cases are in conflict with the aforementioned interpretation of Pericles’ Citizenship Law, they do not stand up to closer inspection. Likewise, the existence of any positive right to legitimate intermarriage beyond the boundaries of the polis community cannot be ascertained for that early period. It will rather be shown that the assembly bothered to convey citizenship or epigamia only as a result of the radically narrow definition of citizenship by Pericles.
Macht, Memoria und Monumente: Marius, Sulla und der Kampf um den öffentlichen Raum
Authors: Stein-Hölkeskamp Elke 
Published: March 2017

Summary
During the first decades of the first century BC, the political situation in Rome was deeply affected by the rivalry between C. Marius and L. Cornelius Sulla. This increasingly bitter rivalry extended to a traditionally important realm of Republican aristocratic self-fashioning, namely the medium of victory and/or honorific monuments displayed in public. This paper offers a detailed account of the effective self-advertising by monuments and above all the systematic destruction of those of his rival Marius, by which Sulla in particular radically changed and redefined the established rules of cultivating and perpetuating the collective memory.
PRESENCIA DE Wolbachia y Leishmania EN UNA POBLACION DE Lutzomyia evansi PRESENTE EN LA COSTA CARIBE DE COLOMBIA
Authors: Vivero-Gómez Rafael J. , Gutiérrez-García Manuela , Moreno-Herrera Claudia Ximena , Cadavid-Restrepo Gloria , Uribe-Soto Sandra 
Published: March 2017

Lutzomyia evansi es importante en salud pública por su participación en la trasmisión de la leishmaniasis visceral y cutánea en la costa caribe de Colombia. Diversos estudios se han desarrollado sobre la poblaciones naturales de Lutzomyia evansi, sin embargo pocos estudios han explorado en profundidad la detección de microorganismos simbióticos (ej. Wolbachia) y de manera simultánea la presencia de Leishmania sp.. El endosimbionte Wolbachia ha sido propuesto en la actualidad como control biológico de insectos vectores de diversas enfermedades tropicales. En el presente estudio el ADN de tres especies del género Lutzomyia colectadas en el municipio de Ovejas (Departamento de Sucre) fue evaluado para detectar la infección natural por la bacteria Wolbachia y la presencia de parásitos del género Leishmania. El ADN total de 176 individuos adultos y 34 inmaduros (larvas y pupas) de Lu. evansi, fue utilizado para evaluar la detección de Wolbachia mediante amplificación por PCR del gen WSP (Proteína Mayor de la Superficie de Wolbachia) y la infección por Leishmania mediante amplificación por PCR de segmentos de los genes HPSN70 (Proteína de Choque Térmico). Se encontró un grupo de machos infectado de forma natural por Wolbachia y nueve grupos de hembras con infección natural por Leishmania, todos pertenecientes a Lutzomyia evansi. El análisis filogenético de la secuencia del gen WSP de Wolbachia indica la ubicación de la cepa detectada dentro del supergrupo B (haplogrupo wLeva) y su relación con haplotipos previamente reportados de Lutzomyia evansi y Lutzomya dubitans. Una región de 418 pb del gen HSP-70N fue secuenciada y mostró similaridad con secuencias de Leishmania luego de realizar el análisis en BlastN. Se confirma la presencia de Wolbachia en poblaciones silvestres de machos de L. evansi y la infección natural por Leishmania spp. en hembras de la misma especie cuya infección por Wolbachia resulto negativa.