bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEGUNAAN EKSTRAK DAUN MENIRAN (Phylanthus niruri) BAGI PENGENDALIAN PENYAKIT IKAN AKIBAT INFEKSI BAKTERI Aeromonas hydrophila
Authors: Supriyadi Hambali , Iftitah Dein 
Published: October 2016

Penyakit ikan merupakan salah satu masalah serius yang selalu dihadapi oleh para pembudi daya ikan. Penyakit akibat infeksi bakteri terutama yang disebabkan oleh Aeromonas hydrophila telah menyebabkan kerugian yang tidak sedikit. Penanggulangan penyakit infeksi bakteri dengan menggunakan antibiotika telah banyak dilakukan. Namun cara seperti ini apabila dilakukan dengan tidak hati-hati akan menimbulkan banyak masalah, di antaranya adalah terbentuknya bakteri yang resisten dan residunya dalam daging ikan. Cara lain yang dipertimbangkan lebih aman adalah dengan cara pencegahan yaitu dengan penggunaan vaksin dan bahan lain yang dapat menimbulkan kekebalan tubuh. Tanaman meniran (Phyllanthus niruri L.) telah banyak digunakan sebagai obat baik pada manusia maupun pada binatang ternak. Dalam tulisan ini akan dibahas tentang efektivitas ekstrak tanaman meniran terhadap bakteri Aeromonas hydrophila baik secara in-vitro maupun secara in-vivo yang diaplikasikan bagi pengobatan terhadap ikan yang terinfeksi bakteri Aeromonas hydrophila.
A multidão em três atos: Poe, Echeverría, Fonseca
Authors: Alencar João Nilson Pereira de 
Published: October 2016

Análise das narrativas "O homem da multidão", de Poe, "El matadero", de Esteban Echeverría, e "Relato de ocorrência em que qualquer semelhança não é mera coincidência", de Rubem Fonseca, com o objetivo de mostrar três momentos da ficcionalização das noções de multidão, povo e massa: no primeiro, a busca pela identidade, no segundo, a ritualização da morte e no terceiro, a barbárie pós-moderna.
Les notables de Palmyre
Authors: Yon Jean-Baptiste 
Published: October 2016

Ce volume vise à mettre en relief les caractères originaux de Palmyre qui passa d’une société à base tribale à une civilisation qu’influence de plus en plus l’Empire romain. Il utilise pour cela l’épigraphie greco-latine, l’épigraphie sémitique et les donnees archéologiques.

La ville partage beaucoup de traits avec le reste de la province romaine, malgré sa position excentrée et ses contacts constants avec des zones moins hellénisées, mais reste empreinte des cultures « orientales » (araméenne, mais aussi arabe, iranienne, babylonienne). On peut ainsi définir l’identité de la ville et de ceux de ses habitants qui apparaissent le mieux, les notables. Ils participaient au fonctionnement de la cité grecque de Palmyre : on peut reconstituer des carrières et des familles qui monopolisaient la scène publique. L’aspect classique, gréco-romain, s’accompagne de la permanence de la culture locale (langue, art, religion, onomastique).

Le commerce caravanier qui fit la gloire de Palmyre est un autre lieu où étudier le rôle des notables et leur influence, hors de la cité et dans l’Empire. À Palmyre même, on peut cartographier leur position sociale grâce à ce qu’ils ont bâti selon les modalités propres à l’évergétisme de Palmyre. Les notables étaient de plus entourés de catégories de population plus discrètes dans les sources (femmes ou affranchis), mais dont l’existence et l’activité n’etaient pas négligeables (ainsi la reine Zénobie). Les notables, par-delà leur propre vie, mettaient en scène la puissance de leur famille, par des constructions de tombeaux. Ces monuments sont aussi le signe d’une pénétration peut-être de plus en plus forte de coutumes qui ont leur origine dans l’Empire romain, sans que disparaissent en aucune manière les traditions originales, en premier lieu l’usage de l’araméen.
Unexpected Information, Investor Attention, and the Contagion Effect of IPO Withdrawal
Authors: Wang Xiongyuan , He Jie 
Published: October 2016

Abstract
We investigate whether firms’ withdrawals of their initial public offering (IPO) applications, as announced by the China Securities Regulatory Commission (CSRC) on 3 April 2013, lead to a contagion effect on the market reaction to other listed firms sponsored by the same agent. We find that listed firms that have the same sponsor as an “IPO withdrawing firm” face a negative market reaction, suggesting that firms’ IPO withdrawals make investors worried about the quality of sponsors and cause negative abnormal equity returns for listed firms with the same sponsor. We also find that this contagion effect is concentrated among listed firms with good accounting information because this event provides more unexpected negative information for investors. In addition, the contagion effect is concentrated among listed firms with more media or analyst coverage. This is because media and analyst coverage attracts investors’ limited attention, making them more pessimistic and finally leading to an increase in the contagion effect. Our study provides support for the contagion theory and investigates the effectiveness of the CSRC’s special checks on financial statements, which may give some suggestions for the healthy development of the IPO market.
Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in “real-world,” everyday clinical practice
Authors: De Berardis Domenico , Fornaro Michele , Orsolini Laura , Iasevoli Felice , Tomasetti Carmine , de Bartolomeis Andrea , Serroni Nicola , De Lauretis Ida , Girinelli Gabriella , Mazza Monica , Valchera Alessandro , Carano Alessandro , Vellante Federica , Matarazzo Ilaria , Perna Giampaolo , Martinotti Giovanni , Di Giannantonio Massimo 
Published: October 2016

ObjectiveAgomelatine is a newer antidepressant but, to date, no studies have been carried out investigating its effects on C-reactive protein (CRP) levels in major depressive disorder (MDD) before and after treatment. The present study aimed (i) to investigate the effects of agomelatine treatment on CRP levels in a sample of patients with MDD and (ii) to investigate if CRP variations were correlated with clinical improvement in such patients.Methods30 adult outpatients (12 males, 18 females) with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnosis of MDD were recruited in “real-world,” everyday clinical practice and treated with a flexible dose of agomelatine for 12 weeks. The Hamilton Rating Scale for Depression (HAM-D) and the Snaith-Hamilton Pleasure Scale (SHAPS) were used to evaluate depressive symptoms and anhedonia, respectively. Moreover, serum CRP was measured at baseline and after 12 weeks of treatment.ResultsAgomelatine was effective in the treatment of MDD, with a significant reduction in HAM-D and SHAPS scores from baseline to endpoint. CRP levels were reduced in the whole sample, with remitters showing a significant difference in CRP levels after 12 weeks of agomelatine. A multivariate stepwise linear regression analysis showed that higher CRP level variation was associated with higher baseline HAM-D scores, controlling for age, gender, smoking, BMI, and agomelatine dose.ConclusionsAgomelatine’s antidepressant properties were associated with a reduction in circulating CRP levels in MDD patients who achieved remission after 12 weeks of treatment. Moreover, more prominent CRP level variation was associated with more severe depressive symptoms at baseline.
Three explanations for extraterrestrials: sensible, unlikely, mad
Authors: Conway Morris Simon 
Published: October 2016

AbstractThe Fermi Paradox (or Question) has moved back into central focus. This is for a number of reasons, not least the evidence for both the abundance and antiquity of many extra-solar systems, the extrapolation of current technological trends to suggest that even inter-galactic colonization (by self-replicating machines) is plausible (if not desirable), and the recurrence of evolutionary solutions (convergence) in the terrestrial biosphere suggesting that features such as intelligence and tool-making are not fortuitous outcomes, but frequent if not universal. Here I review the three possible solutions to the Fermi Paradox. First, extraterrestrials certainly exist (and may be abundant), but for one reason or another (probably mundane) we have not yet met them, or at least found evidence for their existence. Second, against all expectations, we are alone. Third, we have entirely misunderstood the sort of universe we live in and have become unwitting hostages to a strict materialist explanandum that in refusing to acknowledge the other realities of our Universe has derailed any prospect of explaining the apparent absence of extraterrestrials.
How News Type Matters
Authors: Andersen Kim , Bjarnøe Camilla , Albæk Erik , De Vreese Claes H. 
Published: October 2016

Abstract. Today, citizens have the possibility to use many different types of news media and participate politically in various ways. This study examines how use of different news types (hard and soft TV news as well as printed and online versions of broadsheet and tabloid newspapers) indirectly affects changes in offline and online political participation through current affairs knowledge and internal efficacy during nonelection and election time. We use a four-wave national panel survey from Denmark (N = 2,649) and show that use of hard TV news and broadsheets as well as online tabloids positively affects changes in both offline and online political participation through current affairs knowledge and internal efficacy. Use of soft TV news and printed tabloids has a negative indirect effect. These results are more pronounced for online political participation and during election time. However, use of soft TV news also has a positive direct effect on changes in political participation, which suggests a positive impact via other processes.
Animal diversity and ecosystem functioning in dynamic food webs
Authors: Schneider Florian D. , Brose Ulrich , Rall Björn C. , Guill Christian 
Published: October 2016

AbstractSpecies diversity is changing globally and locally, but the complexity of ecological communities hampers a general understanding of the consequences of animal species loss on ecosystem functioning. High animal diversity increases complementarity of herbivores but also increases feeding rates within the consumer guild. Depending on the balance of these counteracting mechanisms, species-rich animal communities may put plants under top-down control or may release them from grazing pressure. Using a dynamic food-web model with body-mass constraints, we simulate ecosystem functions of 20,000 communities of varying animal diversity. We show that diverse animal communities accumulate more biomass and are more exploitative on plants, despite their higher rates of intra-guild predation. However, they do not reduce plant biomass because the communities are composed of larger, and thus energetically more efficient, plant and animal species. This plasticity of community body-size structure reconciles the debate on the consequences of animal species loss for primary productivity.
Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine
Authors: Pei Siran , Liu Li , Zhong Zhaomin , Wang Han , Lin Shuo , Shang Jing 
Published: October 2016

AbstractFluoxetine is widely used to treat depression, including depression in pregnant and postpartum women. Studies suggest that fluoxetine may have adverse effects on offspring, presumably through its action on various serotonin receptors (HTRs). However, definitive evidence and the underlying mechanisms are largely unavailable. As initial steps towards establishing a human cellular and animal model, we analyzed the expression patterns of several HTRs through the differentiation of human induced pluripotent stem (hiPS) cells into neuronal cells, and analyzed expression pattern in zebrafish embryos. Treatment of zebrafish embryos with fluoxetine significantly blocked the expression of multiple HTRs. Furthermore, fluoxetine gave rise to a change in neuropsychology. Embryos treated with fluoxetine continued to exhibit abnormal behavior upto 12 days post fertilization due to changes in HTRs. These findings support a possible long-term risk of serotonin pathway alteration, possibly resulting from the “placental drug transfer”.
Antiangiogenic therapy using endostatin increases the number of ALDH+ lung cancer stem cells by generating intratumor hypoxia
Authors: Yu Yang , Wang Yu-yi , Wang Yi-qin , Wang Xia , Liu Yan-Yang , Wang Jian-Tao , Du Chi , Wang Li , Li Mei , Luo Feng , Jiang Ming 
Published: October 2016

AbstractAntiangiogenic therapy is becoming a promising option for cancer treatment. However, many investigations have recently indicated that these therapies may have limited efficacy and the cancers in most patients eventually develop resistance to these therapies. There is considerable recently acquired evidence for an association of such resistance with cancer stem-like cells (CSLCs). Here, we used xenograft tumor murine models to further suggest that antiangiogenic agents actually increase the invasive and metastatic properties of lung cancer cells. In our experiments with murine lung cancer xenografts, we found that the antiangiogenic agent endostatin increased the population of ALDH+ cells and did so by generating intratumoral hypoxia in the xenografts. We further showed endostatin to cause an increase in the CSLC population by accelerating the generation of tumor hypoxia and by recruiting TAMs, MDSCs and Treg cells, which are inflammatory and immunosuppressive cells and which can secrete cytokines and growth factors such as IL-6, EGF and TGF-β into the tumor microenvironment. All these factors are related with increased CSLC population in tumors. These results imply that improving the clinical efficacy of antiangiogenic treatments will require the concurrent use of CSLC-targeting agents.
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury
Authors: Shigematsu Misako , Koga Tomoaki , Ishimori Ayako , Saeki Kazuko , Ishii Yumiko , Taketomi Yoshitaka , Ohba Mai , Jo-Watanabe Airi , Okuno Toshiaki , Harada Norihiro , Harayama Takeshi , Shindou Hideo , Li Jian-Dong , Murakami Makoto , Hoka Sumio , Yokomizo Takehiko 
Published: October 2016

AbstractAlthough pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice from lung injury caused by a pneumococcal toxin, pneumolysin (PLY). Intratracheal injection of PLY caused lethal acute lung injury (ALI) in BLT2-deficient mice, with evident vascular leakage and bronchoconstriction. Large amounts of cysteinyl leukotrienes (cysLTs), classically known as a slow reactive substance of anaphylaxis, were detected in PLY-treated lungs. PLY-dependent vascular leakage, bronchoconstriction and death were markedly ameliorated by treatment with a CysLT1 receptor antagonist. Upon stimulation by PLY, mast cells produced cysLTs that activated CysLT1 expressed in vascular endothelial cells and bronchial smooth muscle cells, leading to lethal vascular leakage and bronchoconstriction. Treatment of mice with aspirin or loxoprofen inhibited the production of 12-HHT and increased the sensitivity toward PLY, which was also ameliorated by the CysLT1 antagonist. Thus, the present study identifies the molecular mechanism underlying PLY-dependent ALI and suggests the possible use of CysLT1 antagonists as a therapeutic tool to protect against ALI caused by pneumococcal infection.
Surface step terrace tuned microstructures and dielectric properties of highly epitaxial CaCu3Ti4O12 thin films on vicinal LaAlO3 substrates
Authors: Yao Guang , Gao Min , Ji Yanda , Liang Weizheng , Gao Lei , Zheng Shengliang , Wang You , Pang Bin , Chen Y. B. , Zeng Huizhong , Li Handong , Wang Zhiming , Liu Jingsong , Chen Chonglin , Lin Yuan 
Published: October 2016

AbstractControllable interfacial strain can manipulate the physical properties of epitaxial films and help understand the physical nature of the correlation between the properties and the atomic microstructures. By using a proper design of vicinal single-crystal substrate, the interface strain in epitaxial thin films can be well controlled by adjusting the miscut angle via a surface-step-terrace matching growth mode. Here, we demonstrate that LaAlO3 (LAO) substrates with various miscut angles of 1.0°, 2.75°, and 5.0° were used to tune the dielectric properties of epitaxial CaCu3Ti4O12 (CCTO) thin films. A model of coexistent compressive and tensile strained domains is proposed to understand the epitaxial nature. Our findings on the self-tuning of the compressive and tensile strained domain ratio along the interface depending on the miscut angle and the stress relaxation mechanism under this growth mode will open a new avenue to achieve CCTO films with high dielectric constant and low dielectric loss, which is critical for the design and integration of advanced heterostructures for high performance capacitance device applications.
Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia
Authors: Ruther Joachim , Hagström Åsa K. , Brandstetter Birgit , Hofferberth John , Bruckmann Astrid , Semmelmann Florian , Fink Michaela , Lowack Helena , Laberer Sabine , Niehuis Oliver , Deutzmann Rainer , Löfstedt Christer , Sterner Reinhard 
Published: October 2016

AbstractMales of all species of the parasitic wasp genus Nasonia use (4R,5S)-5-hydroxy-4-decanolide (RS) as component of their sex pheromone while only N. vitripennis (Nv), employs additionally (4R,5R)-5-hydroxy-4-decanolide (RR). Three genes coding for the NAD+-dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV10128, and NV10129 are linked to the ability of Nv to produce RR. Here we show by assaying recombinant enzymes that SDRs from both Nv and N. giraulti (Ng), the latter a species with only RS in the pheromone, epimerise RS into RR and vice versa with (4R)-5-oxo-4-decanolide as an intermediate. Nv-derived SDR orthologues generally had higher epimerisation rates, which were also influenced by NAD+ availability. Semiquantitative protein analyses of the pheromone glands by tandem mass spectrometry revealed that NV10127 as well as NV10128 and/or NV10129 were more abundant in Nv compared to Ng. We conclude that the interplay of differential expression patterns and SDR epimerisation rates on the ancestral pheromone component RS accounts for the evolution of a novel pheromone phenotype in Nv.
Re-evaluation of all-plastic organic dye laser with DFB structure fabricated using photoresists
Authors: Tsutsumi Naoto , Nagi Saori , Kinashi Kenji , Sakai Wataru 
Published: October 2016

AbstractOrganic solid-state lasers (OSSLs) with distributed feedback structures can detect nanoscale materials and therefore offer an attractive sensing platform for biological and medical applications. Here we investigate the lasing characteristics, i.e., the threshold and slope efficiency, as a function of the grating depth in OSSL devices with distributed feedback (DFB) structure fabricated using photoresists. Two types of photoresists were used for the DFB structures: a negative photoresist, SU-8 2002, and a positive photoresist, ma-P 1275. The DFB structure was fabricated using a Lloyd-mirror configuration. The active layer was a rhodamine 6G-doped cellulose acetate waveguide. The threshold for the first order mode (m  = 1) was lower than that for the second and third order modes (m = 2, and 3). A low threshold of 27 μJ cm−2 pulse−1 (58 nJ) was obtained using SU-8 2002, with m = 1. The slope efficiency was evaluated as a function of grating depth for each mode and increased as the grating depth increased.
Global Production with Export Platforms*
Authors: Tintelnot Felix 
Published: October 2016

Abstract
Most international commerce is carried out by multinational firms, which use their foreign affiliates both to serve the market of the host country and to export to other markets outside the host country. In this article, I examine the determinants of multinational firms’ location and production decisions and the welfare implications of multinational production. The few existing quantitative general equilibrium models that incorporate multinational firms achieve tractability by assuming away export platforms—that is, they do not allow foreign affiliates of multinationals to export—or by ignoring fixed costs associated with foreign investment. I develop a quantifiable multicountry general equilibrium model, which tractably handles multinational firms that engage in export platform sales and that face fixed costs of foreign investment. I first estimate the model using German firm-level data to uncover the size and nature of costs of multinational enterprise and show that the fixed costs of foreign investment are large. Second, I calibrate the model to data on trade and multinational production for twelve European and North American countries. Counterfactual analysis reveals that multinationals play an important role in transmitting technological improvements to foreign countries and that the pending Canada-EU trade and investment agreement could divert a sizable fraction of the production of EU multinationals from the U.S. to Canada.
An overview on safety of monoclonal antibodies
Authors: Matucci Andrea , Nencini Francesca , Pratesi Sara , Maggi Enrico , Vultaggio Alessandra 
Published: October 2016

Purpose of review
Biological agents have been a treatment option for many chronic immune-mediated diseases as well as oncological conditions. The issue of infusion reactions is of particular importance and at least in some cases related to the immunogenicity of these drugs with the production of antidrug antibodies. Infectious diseases are a well described side-effect of certain biological agents, even if, at least regarding the biological agents used for the treatment of allergic diseases and immune-mediated diseases, the risk has been reduced. Biological agents clearly impact the physiological functions of the immune system also those connected to immunosurveillance against cancers. This review discusses the safety profile to the main biological agents currently in use in allergic and chronic immune-mediated diseases.

Recent findings
By reducing chronic inflammation in immune-mediated diseases, biological agents decrease mortality, cardiovascular events without increasing significantly the risk of cancer. In addition, specific clinical procedure enables the identification of potentially reactive patients and the prevention of acute severe reactions. Overall, the ratio between therapeutic and side-effects is clearly in favor of the former.

Summary
The safety profile of biological agents is, just as much as their efficacy, one of the fundamental criteria justifying their clinical broad use.