bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dopamine loss alters glutamate synapses and transporters in the medial prefrontal cortex and anxiety‐related behaviour in a male MPTP rodent model of Parkinson's disease
Authors: Moore Cindy , Helms Melinda L. , Nipper Michelle A. , Winfrey Lila C. , Finn Deborah A. , Meshul Charles K. 
Published: October 2024

AbstractAnxiety is a prominent non‐motor symptom of Parkinson's disease (PD). Changes in the B‐spectrum recordings in PD patients of the prefrontal cortex correlate with increased anxiety. Using a rodent model of PD, we reported alterations in glutamate synapses in the striatum and substantia nigra following dopamine (DA) loss. We hypothesize that DA loss will result in increased anxiety‐related behaviours and that this will be associated with alterations in glutamate synapses and transporters within the medial prefrontal cortex (mPFC). Following 4 weeks of progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) administration, there was an increase in anxiety‐related behaviours and a 78% decrease in plasma corticosterone levels versus the vehicle (VEH)‐treated mice. This was associated with a 30% decrease in the density of dendritic spines in Layers Il/Ill, and a 53% decrease in the density of glutamate immuno‐gold labelling within vesicular glutamate transporter 1 (Vglut1)‐labelled nerve terminals and spines, with no change within vesicular glutamate transporter 2 (Vglut2) positive terminals/spines in the MPTP versus VEH groups. Our prior work determined that a decrease in striatal glutamate terminal density was associated with an increase in extracellular glutamate levels. There was an increase in protein expression of Vglut1 (40%), Vglut2 (37%) and glutamate aspartate transporter (GLAST) (225%), and a decrease in glutamate transporter 1 (GLT‐1) (50%) and excitatory amino acid carrier 1 (EAAC1) (51%), in the MPTP versus VEH groups within the mPFC. These data suggest that the decrease in dendritic spines within the mPFC following nigrostriatal DA loss may be due to increased extracellular glutamate levels (decrease in glutamate transporters), leading to an increase in anxiety‐related behaviours.
Temporal Knowledge Graph Reasoning Based on Dynamic Fusion Representation Learning
Authors: Chen Hongwei , Zhang Man , Chen Zexi 
Published: October 2024

ABSTRACTRecently, significant progress has been made in completing static knowledge graphs. However, knowledge tends to evolve with time, and static knowledge graph completion (KGC) methods struggle to capture the changes. Therefore, temporal knowledge graph (TKG) reasoning has become a focus of research. Most existing TKG methods incorporate temporal information into triplets and transform them into KGC tasks, ignoring the important influence of time information and implicit relationships between entities. In this paper, we propose a new method called TD‐RKG, which addresses the challenges of temporal variability and implicit entity correlations based on a dynamic fusion representation learning approach. The method consists of four modules: dynamic local recurrent encoding layer, dynamic implicit encoding layer, dynamic global information attention layer and decoding layer. Experimental results on three benchmark datasets demonstrate substantial improvements in TD‐RKG across multiple evaluation metrics.
Infectious complications of Stevens‐Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta‐analysis
Authors: Stewart Thomas Jonathan , Chan Chon‐Wai Jeremy , Shah Hemali , Frew John 
Published: October 2024

AbstractStevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to medications characterized by keratinocyte necrosis leading to loss of protective barrier function and increased susceptibility to infection. Infection is a major cause of morbidity, and septicemia is the leading cause of mortality in this population. This systematic review and meta‐analysis aimed to determine infectious complications' prevalence and risk factors in adults with SJS and TEN. This review was registered with the International Platform of Registered Systematic Review and Meta‐Analysis Protocols (INPLASY) and conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) reporting guidelines. Thirty‐six articles describing results from 1446 cases were included. Skin infection was the most commonly diagnosed infection. The pooled prevalence of sepsis, respiratory tract infection, skin infection, and urinary tract infection was 27.3%, 21.5%, 37.5%, and 21.8%, respectively. Staphylococcus aureus was the most commonly identified organism. The overall quality of the studies was suboptimal, and the level of heterogeneity was high. The skin, bloodstream, respiratory, and urinary tracts are most commonly infected in the course of adult SJS and TEN. During hospitalization, clinicians should closely monitor and promptly investigate for these as well as several other infectious complications. More research is needed, with greater attention to the risk factors and causative organisms that cause these infections.
Exploring the association between chronic prostatitis and the risk of herpes zoster in a cohort study in Taiwan
Authors: Lai Shih‐Wei , Kuo Yu‐Hung , Liao Kuan‐Fu 
Published: October 2024

ObjectiveThe aim of the cohort research was to study the association between chronic prostatitis and the probability of herpes zoster in Taiwan.MethodsUsing the National Health Insurance Research Database (NHIRD) of Taiwan, we selected male persons newly diagnosed with chronic prostatitis aged 20–84 years between 2013 and 2020. These male persons were then matched with a non‐prostatitis group who did not have a diagnosis of prostatitis by using 1:1 propensity score matching on age and relevant comorbidities. All participants were observed either until a new diagnosis of herpes zoster was noted or until the completion of the study period in 2020. Cox proportional hazards regression analysis was employed to study the hazard ratio (HR) and 95% confidence interval (CI) for the risk of herpes zoster associated with chronic prostatitis.ResultsA total of 69 239 participants with chronic prostatitis and 69 239 participants with non‐prostatitis were included in the analysis. The incidence rate of herpes zoster was higher in participants with chronic prostatitis compared to the non‐prostatitis group (8.03 per 1000 person‐years for chronic prostatitis group versus 4.74 per 1000 person‐years for non‐prostatitis group, incidence rate ratio = 1.69, and 95%CI = 1.59–1.81). After adjusting for co‐variables, participants with chronic prostatitis were found to have a higher risk of developing herpes zoster compared to the non‐prostatitis group (adjusted HR = 1.69, 95%CI = 1.59–1.81, and p < 0.001).ConclusionThis cohort research suggests that people with chronic prostatitis may have a greater risk of developing herpes zoster compared to the non‐prostatitis group in Taiwan. Preventive strategies, such as the administration of the herpes zoster vaccine, might be beneficial in people with chronic prostatitis.
Psychosocial risk factors of lower urinary tract symptoms among working women
Authors: Yoo Hyoungseob , Kang Mo‐Yeol 
Published: October 2024

ObjectivesLower urinary tract symptoms (LUTS) are prevalent among women, affecting not only their physical well‐being but also their quality of working life. This study aimed to assess the relationship between psychosocial factors at work and LUTS among working women. Additionally, we sought to investigate whether women with psychosocial risk factors at work reported reduced quality of life (QOL) and a higher degree of productivity loss from absenteeism and presenteeism.MethodsAn online survey was conducted to collect the demographic characteristics, occupational risk factors, and LUTS among employed Korean women. Shift work, weekly working hours, occupational stress, and emotional labor were surveyed as psychosocial risk factors at work. The association between psychosocial risk factors and LUTS was assessed using adjusted logistic regression. The relationships between psychosocial risk factors and LUTS‐related outcomes, such as were examined using a generalized linear model.ResultsOf the 1057 participants, 260 (24.6%) and 294 (27.81%) had overactive bladder and urinary incontinence, respectively. Job stress, emotional labor, and night‐shift work are significantly associated with a higher prevalence of LUTS, which reduce workers' QOL and labor productivity through absenteeism and presenteeism due to urination symptoms.ConclusionsPsychosocial factors at work, particularly job stress, emotional labor, and night‐shift work, were significantly associated with a higher prevalence of LUTS, leading to reduced QOL and labor productivity due to urination symptoms.
Neoliberalism in question: The Philippines' nurse education and labour export as liberal neo‐statist development agenda
Authors: Cabanda Exequiel , Yeoh Brenda S. A. , Acedera Kristel A. F. , Walton‐Roberts Margaret 
Published: October 2024

AbstractMany scholars have used neoliberalism as an analytical framework to examine the Philippines' labour export policy. While neoliberalism entails a retreat of the state in favour of market reforms, evidence shows that state intervention of the market becomes larger and stronger over time. This paper utilises liberal neo‐statism as an alternative framework to understand the Philippines' nurse labour export by explaining that the state's role is larger than and goes beyond labour brokerage. Following the historical institutionalism approach, we show the significant timing, sequence, and path dependence that affect the emergence of institutions that govern the Philippines' nurse labour export. Our paper reveals how specific policies and regulations in labour export are tucked within the disguise of market reforms, but which are manifest within a larger state's control. These policies serve as the state's apparatus for remittance generation and protection of migrant labour rights and welfare.
Amoebic encephalitis within Australia
Authors: Carija Samantha C. , Levy Avram , Weaire‐Buchanan Graham , Lee Terence , Woodward Robin , Gazeley Jake , Edwards Troy A. , Dyke Jason M. , Fabian Vicki , Norton Katherine , Chapman Andrew , Ingram Paul R. 
Published: October 2024

AbstractGranulomatous amoebic encephalitis is a rare but likely under‐recognised form of subacute, usually fatal, encephalitis. We present an illustrative case report and literature review of Australian cases, summarising clinical features, diagnostic methods, treatment and outcomes.
‘My Journey’: A Qualitative Study of Recovery From the Perspective of Individuals With Chronic Mental Illness
Authors: Yüksel Rüveyda , Çekiç Yasemin , Çolak Burçin 
Published: October 2024

ABSTRACTDue to the humanistic paradigm shift in recent years, mental health recovery has been approached through personal recovery beyond the limits of the biomedical perspective, emphasising the subjective perception and uniqueness of the individual. Therefore, approaching recovery perceptions from patients' perspectives has gained importance. This study aimed to examine in depth the recovery perceptions of individuals with chronic mental illness. It is a qualitative study conducted using a phenomenological design. The study group consisted of 12 patients who had been undergoing treatment for mental illness for at least 1 year and were selected by purposive sampling method. Data were collected face‐to‐face using a semi‐structured interview form and analysed using the content analysis technique. The content analysis revealed three main themes and seven sub‐themes. The themes were journey (a meaningful life, optimal functioning, new identity), journey ticket (resilience, support systems) and stones on the road (traditional perspective, barriers). In conclusion, the study results revealed that individuals in the recovery process required support and counselling to make sense of the process and adapt their identity. Employment should be used more effectively in the recovery process of individuals with chronic mental illness. Recovery can only be achieved by breaking away from the traditional perspective of healing and combating the perception of society towards patients. Accordingly, psychiatric nurses should provide effective guidance and counselling to show that individuals can create and live a meaningful life alongside their illnesses.
Nurses as UN champions: Increasing nursing presence and influence at the United Nations
Authors: Bellegarde‐Armstrong Kasey , Potter Teddie 
Published: October 2024

AbstractBackgroundRepresenting half of the global health workforce, nurses are critical to health promotion, disease prevention, and the economic and social needs of populations. However, nursing expertise is underutilized in the UN System, and nurses are underprepared for roles in policy to influence global health and sustainable development. Innovative education strategies are necessary to address the sidelining of nursing expertise in these spaces and build nursing literacy in shaping global policy.AimThis quality improvement project aimed to develop and evaluate a model to build a USA‐based school of nursing's literacy and engagement with the United Nations (UN) System.MethodsA Doctor of Nursing Practice (DNP) student developed an innovative educational model, the United Nations Essentials for Global Nursing Leadership, in partnership with a school of nursing (SON), to build faculty knowledge and skills on initiating and sustaining bidirectional engagement with the UN. In 2023, SON faculty piloted the model, and pre‐/post‐intervention survey data were utilized for improvement.ResultsParticipants reported increased knowledge, awareness, and confidence related to the UN System and their ability to engage as policy influencers, health diplomats, and global citizens. In total, 100% of participants volunteered to hold the role of UN champion for the SON.DiscussionThis innovative model advances nursing knowledge and coherence in the UN System and key areas of policy, diplomacy, and global governance for meaningful UN engagement.Conclusion and implications for nursing, health, and social policyModels that invest in closing the global nursing leadership preparation gap can raise the profession's visible UN presence and strategic policy influence at a critical time for people and the planet.
The N‐terminal fragment of histone deacetylase 4 (1‐669aa) promotes chondrocyte apoptosis via the p53‐dependent endoplasmic reticulum stress pathway
Authors: Guo Li , Zhuo Xuhao , Lu Chengyang , Guo Hua , Chen Zhi , Wu Gaige , Liu Fengrui , Wei Xiaochun , Rong Xueqin , Li Pengcui 
Published: October 2024

AbstractExogenous administration of the histone deacetylation 4 (HDAC4) protein can effectively delay osteoarthritis (OA) progression. However, HDAC4 is unstable and easily degrades into N‐terminal (HDAC4‐NT) and C‐terminal fragments, and the HDAC4‐NT can exert biological effects, but little is known about its role in chondrocytes and cartilage. Thus, the roles of HDAC4‐NT fragments (1‐289aa, 1‐326aa and 1‐669aa) in chondrocytes and cartilage were evaluated via real‐time cell analysis (RTCA), safranin O staining, Sirius Red staining and nanoindentation. Molecular mechanisms were profiled via whole‐transcriptome sequencing (RNA‐seq) and verified in vitro and in vivo by a live cell real‐time monitoring system, flow cytometry, western blotting and immunohistochemistry. The results showed that 1‐669aa induced chondrocyte death and cartilage injury significantly, and the differentially expressed genes (DEGs) were enriched mainly in the apoptotic term and p53 signalling pathway. The validation experiments showed that 1‐669aa induced chondrocyte apoptosis via the endoplasmic reticulum stress (ERS) pathway, and up‐regulated p53 expression was essential for this process. Thus, we concluded that the HDAC4‐NT fragment 1‐669aa induces chondrocyte apoptosis via the p53‐dependent ERS pathway, suggesting that in addition to overexpressing HDAC4, preventing it from degradation may be a new strategy for the treatment of OA.
JAK2V617F‐dependent down regulation of SHP‐1 expression participates in the selection of myeloproliferative neoplasm cells in the presence of TGF‐β
Authors: Aoun Céline , Maslah Nabih , Ganesan Saravanan , Salomao Norman , Gendron Romane , Awan Toor Sarah , Letort Gil , Gou Panhong , Bonnamy Mélina , Parietti Véronique , Kiladjian Jean‐Jacques , Giraudier Stephane , Cassinat Bruno 
Published: October 2024

AbstractMyeloproliferative neoplasms (MPNs) are characterized by an increased production of blood cells due to the acquisition of mutations such as JAK2V617F. TGF‐β, whose secretion is increased in MPN patients, is known to negatively regulate haematopoietic stem cell (HSC) proliferation. Using an isogenic JAK2V617F or JAK2 wild‐type UT‐7 cell line we observed that JAK2V617F cells resist to TGF‐β antiproliferative activity. Although TGF‐β receptors and SMAD2/3 expressions are similar in both cell types, TGF‐β‐induced phosphorylation of SMAD2/3 is reduced in UT‐7 JAK2V617F cells compared with JAK2 WT cells. We confirmed that JAK2V617F mutated cells are resistant to the antiproliferative effect of TGF‐β in a competitive assay as we observed a positive selection of JAK2V617F cells when exposed to TGF‐β. Using cell lines, CD34‐positive cells from MPN patients and bone marrow cells from JAK2V617F knock‐in mice we identified a down regulation of the SHP‐1 phosphatase, which is required for the regulation of HSC quiescence by TGF‐β. The transduction of SHP‐1 cDNA (but not a phosphatase inactive cDNA) restores the antiproliferative effect of TGF‐β in JAK2V617F mutated cells. Finally, SC‐1, a known agonist of SHP‐1, antagonized the selection of JAK2V617F mutated cells in the presence of TGF‐β. In conclusion, we show a JAK2‐dependent down regulation of SHP‐1 in MPN patients' cells which is related to their resistance to the antiproliferative effect of TGF‐β. This may participate in the clonal selection of cancer cells in MPNs.
The effect of education given to secondary school students on hand hygiene behaviors: a Quasi experimental study
Authors: Erkoca Semiha , Dündar Nursel , Çal Ayşe 
Published: October 2024

AbstractAimsThis study aimed to examine the effect of the hand hygiene education on middle school students' behavioral scores related to hand hygiene practices.DesignThe research adheres to a quasi‐experimental design suitable for the pre‐test Posttest model with a control group.MethodsThe population of the study consists of a total of 1159 students, comprising 5th, 6th, 7th, and 8th graders. During the first semester of the 2021–2022 academic year, face‐to‐face education was conducted at a middle school located in Ankara. Two face‐to‐face training sessions were conducted to increase awareness of hand hygiene.ResultsThe groups indicate homogeneity in terms of demographic characteristics. The mean hand hygiene behavior score was 56.45 ± 8.03 before the education in the intervention group, which increased to 59.79 ± 7.62 after the education. In the control group, the mean score was 55.98 ± 7.89 before the education and 57.15 ± 7.63 after the education. It was found that after the educational program, there was a statistically significant increase in hand hygiene behavior scores of the groups.ConclusionThe research findings indicate a beneficial impact of hand hygiene education on students' average behavioral scores.ImpactTo foster lasting behavioral changes from a young age, it is advisable to implement hygiene education in schools periodically, including targeted interventions for middle school students.
Clinical and laboratory predictors for bacteremia in critically ill calves
Authors: Pas Mathilde L. , Bokma Jade , Boyen Filip , Pardon Bart 
Published: October 2024

AbstractBackgroundSepsis is a main contributor to calf mortality, but diagnosis is difficult.ObjectivesDevelop and validate a predictive model for bacteremia in critically ill calves (CIC).AnimalsA total of 334 CIC, sampled for blood culture.MethodsCross‐sectional study. Multivariable logistic regression and classification tree analysis on clinical, ultrasonographic, and laboratory variables were performed on a dataset including all animals. Model validation was done on 30% of the dataset. Similar statistics (except validation) were performed on a subset of the database (n = 143), in which presumed contaminants were excluded.ResultsThe best performing model to predict bacteremia, taking all detected bacteria into account, included tachypnea, tachycardia, acidemia, hypoglycemia, venous hypoxemia, and hypoproteinemia. Sensitivity and specificity of this model were 70.6% and 98.0%, respectively, but decreased to 61.5% and 91.7% during model validation. The best‐performing model, excluding presumed contaminants, included abnormal temperature, heart rate, absence of enteritis, hypocalcemia, and hyperlactatemia as risk factors for bacteremia. Sensitivity and specificity of this model were 71.4% and 93.9%, respectively. Both classification trees performed less well in comparison to logistic regression. The classification tree excluding presumed contaminants, featured hypoglycemia, absence of diarrhea, and hyperlactatemia as risk factors for bacteremia. Sensitivity and specificity were 39.4% and 92.7%, respectively.Conclusions and Clinical ImportanceHypoglycemia, hyperlactatemia, and hypoproteinemia seem relevant in assessing bacteremia in CIC. The performance of these models based on basic clinical and blood variables remains insufficient to predict bacteremia.
Impacts of Indoor Air Quality on Working‐Age Populations' Subjective Well‐Being: Evidence From China Labor Dynamics Survey
Authors: Zhou Zhengqing , Ai Hongshan , Zhang Xi 
Published: October 2024

ABSTRACTOutdoor air pollution can affect physical labor productivity and mental health, but it remains to be studied how indoor air quality (IAQ) exposure affects working‐age populations' subjective well‐being and physical health. Here, the first evidence of a link between IAQ and the subjective well‐being of working‐age populations has been provided using the dataset from a longitudinal survey in China. Using household ventilation as an instrument variable (IV) of IAQ revealed that IAQ improvements increased working‐age populations' subjective well‐being and life satisfaction by significantly affecting their physical health. Our analysis shows that an increase in IAQ by one standard deviation improves working‐age populations' subjective well‐being by 0.041 standard deviations. The marginal willingness to pay for IAQ is approximately 98.09 CNY. Compared with outdoor air quality, the impact of IAQ on well‐being and life satisfaction is more conspicuous. The results are robust to a variety of alternative specifications. For developing countries, improving IAQ is a new channel toward enhancing life quality, with lower economic and social costs.