bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasopharyngeal bacterial carriage in young children in Greenland: a population at high risk of respiratory infections
Authors: NAVNE J. E. , BØRRESEN M. L. , SLOTVED H. C. , ANDERSSON M. , MELBYE M. , LADEFOGED K. , KOCH A. 
Published: July 2016

SUMMARYThe incidence of childhood respiratory infections in Greenland is among the highest globally. We performed a population-based study of 352 Greenlandic children aged 0–6 years aiming to describe rates and risk factors for carriage of four key bacteria associated with respiratory infections, their antimicrobial susceptibility and inter-bacterial associations. Nasopharyngeal swabs were tested for Streptococcus pneumoniae grouped by serotypes included (VT) or not included (NVT) in the 13-valent pneumococcal conjugate vaccine, non-typable Haemophilus influenzae (NTHi), Staphylococcus aureus and Moraxella catarrhalis. S. pneumoniae was detected from age 2 weeks with a peak carriage rate of 60% in 2-year-olds. Young age and having siblings attending a daycare institution were associated with pneumococcal carriage. Overall co-colonization with ⩾2 of the studied bacteria was 52%. NTHi showed a positive association with NVT pneumococci and M. catarrhalis, respectively, M. catarrhalis was positively associated with S. pneumoniae, particular VT pneumococci, whereas S. aureus were negatively associated with NTHi and M. catarrhalis. Nasopharyngeal bacterial carriage was present unusually early in life and with frequent co-colonization. Domestic crowding increased odds of carriage. Due to important bacterial associations we suggest future surveillance of pneumococcal conjugate vaccine's impact on carriage in Greenland to also include other pathogens.
PAEAN: Portable and scalable runtime support for parallel Haskell dialects
Authors: BERTHOLD JOST , LOIDL HANS-WOLFGANG , HAMMOND KEVIN 
Published: July 2016

AbstractOver time, several competing approaches to parallel Haskell programming have emerged. Different approaches support parallelism at various different scales, ranging from small multicores to massively parallel high-performance computing systems. They also provide varying degrees of control, ranging from completely implicit approaches to ones providing full programmer control. Most current designs assume a shared memory model at the programmer, implementation and hardware levels. This is, however, becoming increasingly divorced from the reality at the hardware level. It also imposes significant unwanted runtime overheads in the form of garbage collection synchronisation etc. What is needed is an easy way to abstract over the implementation and hardware levels, while presenting a simple parallelism model to the programmer. The PArallEl shAred Nothing runtime system design aims to provide a portable and high-levelshared-nothingimplementation platform for parallel Haskell dialects. It abstracts over major issues such as work distribution and data serialisation, consolidating existing, successful designs into a single framework. It also provides an optionalvirtualshared-memory programming abstraction for (possibly) shared-nothing parallel machines, such as modern multicore/manycore architectures or cluster/cloud computing systems. It builds on, unifies and extends, existing well-developed support for shared-memory parallelism that is provided by the widely used GHC Haskell compiler. This paper summarises the state-of-the-art in shared-nothing parallel Haskell implementations, introduces the PArallEl shAred Nothing abstractions, shows how they can be used to implement three distinct parallel Haskell dialects, and demonstrates that good scalability can be obtained on recent parallel machines.
Visualizing Iraq: oil, cinema, and the modern city
Authors: DAMLUJI MONA 
Published: July 2016

ABSTRACTSummoning the popularity and prestige of cinema, the Iraq Petroleum Company (IPC) invented the image of Baghdad for Iraqi audiences as the sight/site of oil modernity in the 1950s. In other words, oil urbanization, or the modernization of the city as shaped by the petroleum industry and its revenues, in Iraq cannot be understood apart from the representation of Baghdad as visible evidence of petroleum's promise to benefit the national population. The British-controlled oil company in Iraq produced a programme of at least two-dozen sponsored films and cine-magazine episodes between 1951 and 1958, which this essay examines as an emblematic case of neo-colonial film, constituting an archive of media practices that bridge the categories of colonial film on one hand, and industrial film on the other. After World War II, the Atlantic Charter reinforced the right to democratic self-rule as a global norm and the British state developed creative tactics to abet its continued control over strategic resources in its colonized territories. Oil above all became central to this story and, as this essay will show, British oil companies played a fundamental role towards reinventing the imperial project in the post-colonial context of Iraq. Through a contextualized analysis of the IPC films, I argue that the company public relations office utilized the conventional approaches and standard formats of colonial and industrial film – including montage, scripted voiceover and staged b-roll – to narrativize the association between neo-colonialist practices of oil extraction and national development as causal, inherent and positive.
San Francisco views: Robert Bechtle and the reformulation of urban vision
Authors: GILMAN BRIDGET 
Published: July 2016

ABSTRACTWhen Photorealism arrived on the art scene in the 1960s, it received considerable media attention for its striking illusionism and unparalleled commitment to fusing painting and photography. But many judged the style to be merely retrograde realism disguised by the use of contemporary source photographs or, more harshly, as an unthinking reproduction of capitalist culture – i.e. a kind of toothless Pop art slickly rendered for the masses. Though the style now constitutes a familiar part of the contemporary art world, few have sought to understand or mitigate several decades of critical antipathy and neglect. This essay examines painter Robert Bechtle's work, contra the historic assumption of Photorealism's social irrelevance. Bechtle's images of San Francisco, defined by architecture and automobiles ubiquitous in post-1945 Californian neighbourhoods, present the city without overt commentary. Yet, through this seemingly ordinary iconography, the artist upends deep-rooted urban visual paradigms, linking the traditionally vaunted city centre to its apparently subsidiary suburbs. Bechtle offers the viewer not iconic landmarks or arresting vistas, but rather a way to comprehend how everyday life in the city is informed by significant configurations of residential architecture, under-remarked geographic particularities and historical development that blurs the distinction between centre and periphery. These representational strategies are central to understanding the ways in which the Bay Area – and indeed much of post-war America – is experienced as built environment and social space.
Buses from nowhere: television and anti-busing activism in 1970s urban America
Authors: DELMONT MATT 
Published: July 2016

ABSTRACT‘Busing’, in which students were transported by school buses to achieve court-ordered or voluntary school desegregation, became one of the nation's most controversial civil rights issues in the decades after Brown vs. Board of Education (1954). Focusing on Florida Governor Claude Kirk and Pontiac housewife activist Irene McCabe, this essay examines how busing opponents turned the conventions of television news – its emphasis on newsworthy events and crisis; its selective use of historical context; and its nominal political neutrality – to their advantage, staging television friendly protests that positioned mothers and children as victims of activist judges and federal bureaucrats, and framed their support for segregated neighbourhoods and schools in the colour-blind rhetoric of homeowners’ rights. For politicians who aspired to the national stage, like Florida Governor Claude Kirk, busing offered a recognizable issue on which to take a stand. When Kirk protested court-ordered busing by suspending a local school board in Manatee County (Bradenton, Florida) and appointing himself school superintendent, he was not only appealing to Florida voters but also to television viewers in cities like Nashville, St Louis and Seattle, many of whom wrote to convey their support. When Vice-President Spiro Agnew complained that television network news ‘can elevate men from obscurity to national prominence within a week’, he was referring to Black Power author and activist Stokely Carmichael, but television news also propelled grassroots anti-busing activists like Irene McCabe to national prominence. McCabe, who staged a widely covered six-week march from Pontiac to Washington DC to protest busing, made frequent television appearances because networks deemed her newsworthy, not necessarily because newscasters agreed with her politics. Repeated television coverage turned relatively minor busing battles in Bradenton and Pontiac into national news and established Kirk and McCabe as icons of busing opposition in the early 1970s.
CENTRAL LIMIT THEOREM FOR THE MODULUS OF CONTINUITY OF AVERAGES OF OBSERVABLES ON TRANSVERSAL FAMILIES OF PIECEWISE EXPANDING UNIMODAL MAPS
Authors: de Lima Amanda , Smania Daniel 
Published: July 2016

Consider a$C^{2}$family of mixing$C^{4}$piecewise expanding unimodal maps$t\in [a,b]\mapsto f_{t}$, with a critical point$c$, that is transversal to the topological classes of such maps. Given a Lipchitz observable$\unicode[STIX]{x1D719}$consider the function$$\begin{eqnarray}{\mathcal{R}}_{\unicode[STIX]{x1D719}}(t)=\int \unicode[STIX]{x1D719}\,d\unicode[STIX]{x1D707}_{t},\end{eqnarray}$$where$\unicode[STIX]{x1D707}_{t}$is the unique absolutely continuous invariant probability of$f_{t}$. Suppose that$\unicode[STIX]{x1D70E}_{t}>0$for every$t\in [a,b]$, where$$\begin{eqnarray}\unicode[STIX]{x1D70E}_{t}^{2}=\unicode[STIX]{x1D70E}_{t}^{2}(\unicode[STIX]{x1D719})=\lim _{n\rightarrow \infty }\int \left(\frac{\mathop{\sum }_{j=0}^{n-1}\left(\unicode[STIX]{x1D719}\circ f_{t}^{j}-\int \unicode[STIX]{x1D719}\,d\unicode[STIX]{x1D707}_{t}\right)}{\sqrt{n}}\right)^{2}\,d\unicode[STIX]{x1D707}_{t}.\end{eqnarray}$$We show that$$\begin{eqnarray}m\left\{t\in [a,b]:t+h\in [a,b]\text{ and }\frac{1}{\unicode[STIX]{x1D6F9}(t)\sqrt{-\log |h|}}\left(\frac{{\mathcal{R}}_{\unicode[STIX]{x1D719}}(t+h)-{\mathcal{R}}_{\unicode[STIX]{x1D719}}(t)}{h}\right)\leqslant y\right\}\end{eqnarray}$$converges to$$\begin{eqnarray}\frac{1}{\sqrt{2\unicode[STIX]{x1D70B}}}\int _{-\infty }^{y}e^{-\frac{s^{2}}{2}}\,ds,\end{eqnarray}$$where$\unicode[STIX]{x1D6F9}(t)$is a dynamically defined function and$m$is the Lebesgue measure on$[a,b]$, normalized in such way that$m([a,b])=1$. As a consequence, we show that${\mathcal{R}}_{\unicode[STIX]{x1D719}}$is not a Lipchitz function on any subset of$[a,b]$with positive Lebesgue measure.
Building value chains for indigenous fruits: lessons from camu-camu in Peru
Authors: Blare Trent , Donovan Jason 
Published: July 2016

AbstractGovernments and NGOs have enthusiastically promoted value chains for lesser-known indigenous fruits in the pursuit of poverty reduction and other development goals. This paper examines experiences in Peru in building the value chain for camu-camu—a fruit native to the Amazon that is in the process of being domesticated. We look at interventions to build the chain, the environment in which the chain operates, the implications of chain development on livelihoods, and prospects for future chain development. Information was collected from gray literature as well as from primary data from household and key informant interviews. The results of this study suggest that the emergence of the camu-camu chain has led to higher farm income without generating large trade-offs in livelihood activities or the environment. However, the results also demonstrate an unrealized potential to achieve greater impact at scale due to gaps in services and inputs, limited coordination among farmers and chain actors, and a risky business environment. Building value chains for lesser-known fruits will require more than a techo-managerial focus on smallholder production. Greater attention is required to build stronger public–private collaboration to expand and diversify markets, with particular attention on strengthening institutions and growing local markets for high-value products.
Lentil enhances agroecosystem productivity with increased residual soil water and nitrogen
Authors: Gan Yantai , Hamel Chantal , Kutcher H. Randy , Poppy Lee 
Published: July 2016

AbstractLentil (Lens culinaris Medikus) may have a potential to enhance the productivity of agroecosystems in dry areas where water and nutrients are limited. This study quantified soil water, residual soil nitrogen (N), and crop yields in lentil-based systems in comparison with continuous cereal and conventional summerfallow systems. A 3-yr cropping sequence study was conducted for three cycles in Saskatchewan (50.28°N, 107.79°W) from 2007 to 2011. On average, soil retained 187, 196 and 337 mm of water in the 0–1.2 m depth at crop harvest in 2008, 2009 and 2010, respectively. Summerfallow contained the same amounts of water as the cropped treatments at the harvest in 2009 and 2010. However, in 2008, summerfallow contained more soil water than the cropped treatments. The effect of lentil cultivar on soil water conservation varied with years; the cultivars Glamis, Laird and Sedley conserved highest amounts of soil water by the planting time of 2009 and 2010, but no differences were found among cultivars in 2011. Soil available N (NO3− + NH4+) at spring planting time was 50.4 kg ha−1 in the preceding lentil treatments, which was 44% higher compared with preceding barley or flax, but was 25% lower compared with preceding summerfallow. Lentil cultivars had a similar amount of soil residual N. Grain production in the 3-yr rotation averaged 6.3 t ha−1 per rotation for the wheat–lentil–durum system and 6.8 t ha−1 for the wheat–cereal–durum monoculture, averaging 36% greater compared with wheat–summerfallow–durum system. The lentil system increased total grain production through the access of residual soil water and biologically fixed N, whereas continuous cereal system relies on inorganic fertilizer input for yield. Summerfallow system relies on ‘mining’ the soil for nutrients. We conclude that the adoption of lentil systems will enhance grain production through the use of residual soil water and available N.
The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
Authors: Liang Chih-Chao , Li Zhuolun , Lopez-Martinez David , Nicholson William V. , Vénien-Bryan Catherine , Cohn Martin A. 
Published: July 2016

AbstractThe Fanconi anaemia (FA) pathway is important for the repair of DNA interstrand crosslinks (ICL). The FANCD2–FANCI complex is central to the pathway, and localizes to ICLs dependent on its monoubiquitination. It has remained elusive whether the complex is recruited before or after the critical monoubiquitination. Here, we report the first structural insight into the human FANCD2–FANCI complex by obtaining the cryo-EM structure. The complex contains an inner cavity, large enough to accommodate a double-stranded DNA helix, as well as a protruding Tower domain. Disease-causing mutations in the Tower domain are observed in several FA patients. Our work reveals that recruitment of the complex to a stalled replication fork serves as the trigger for the activating monoubiquitination event. Taken together, our results uncover the mechanism of how the FANCD2–FANCI complex activates the FA pathway, and explains the underlying molecular defect in FA patients with mutations in the Tower domain.
Human serum-derived protein removes the need for coating in defined human pluripotent stem cell culture
Authors: Pijuan-Galitó Sara , Tamm Christoffer , Schuster Jens , Sobol Maria , Forsberg Lars , Merry Catherine L. R. , Annerén Cecilia 
Published: July 2016

AbstractReliable, scalable and time-efficient culture methods are required to fully realize the clinical and industrial applications of human pluripotent stem (hPS) cells. Here we present a completely defined, xeno-free medium that supports long-term propagation of hPS cells on uncoated tissue culture plastic. The medium consists of the Essential 8 (E8) formulation supplemented with inter-α-inhibitor (IαI), a human serum-derived protein, recently demonstrated to activate key pluripotency pathways in mouse PS cells. IαI efficiently induces attachment and long-term growth of both embryonic and induced hPS cell lines when added as a soluble protein to the medium at seeding. IαI supplementation efficiently supports adaptation of feeder-dependent hPS cells to xeno-free conditions, clonal growth as well as single-cell survival in the absence of Rho-associated kinase inhibitor (ROCKi). This time-efficient and simplified culture method paves the way for large-scale, high-throughput hPS cell culture, and will be valuable for both basic research and commercial applications.
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
Authors: Sánchez-Huertas Carlos , Freixo Francisco , Viais Ricardo , Lacasa Cristina , Soriano Eduardo , Lüders Jens 
Published: July 2016

AbstractNeurons display a highly polarized microtubule network that mediates trafficking throughout the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn migrating neurons, the microtubule network is organized by the centrosome. During neuron maturation, however, the centrosome gradually loses this activity, and how microtubules are organized in more mature neurons remains poorly understood. Here, we demonstrate that microtubule organization in post-mitotic neurons strongly depends on non-centrosomal nucleation mediated by augmin and by the nucleator γTuRC. Disruption of either complex not only reduces microtubule density but also microtubule bundling. These microtubule defects impair neurite formation, interfere with axon specification and growth, and disrupt axonal trafficking. In axons augmin does not merely mediate nucleation of microtubules but ensures their uniform plus end-out orientation. Thus, the augmin-γTuRC module, initially identified in mitotic cells, may be commonly used to generate and maintain microtubule configurations with specific polarity.
Atomic scale observation of oxygen delivery during silver–oxygen nanoparticle catalysed oxidation of carbon nanotubes
Authors: Yue Yonghai , Yuchi Datong , Guan Pengfei , Xu Jia , Guo Lin , Liu Jingyue 
Published: July 2016

AbstractTo probe the nature of metal-catalysed processes and to design better metal-based catalysts, atomic scale understanding of catalytic processes is highly desirable. Here we use aberration-corrected environmental transmission electron microscopy to investigate the atomic scale processes of silver-based nanoparticles, which catalyse the oxidation of multi-wall carbon nanotubes. A direct semi-quantitative estimate of the oxidized carbon atoms by silver-based nanoparticles is achieved. A mechanism similar to the Mars–van Krevelen process is invoked to explain the catalytic oxidation process. Theoretical calculations, together with the experimental data, suggest that the oxygen molecules dissociate on the surface of silver nanoparticles and diffuse through the silver nanoparticles to reach the silver/carbon interfaces and subsequently oxidize the carbon. The lattice distortion caused by oxygen concentration gradient within the silver nanoparticles provides the direct evidence for oxygen diffusion. Such direct observation of atomic scale dynamics provides an important general methodology for investigations of catalytic processes.
Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
Authors: Bottos Alessia , Gotthardt Dagmar , Gill Jason W. , Gattelli Albana , Frei Anna , Tzankov Alexandar , Sexl Veronika , Wodnar-Filipowicz Aleksandra , Hynes Nancy E. 
Published: July 2016

AbstractThe JAK/STAT pathway is an attractive target for breast cancer therapy due to its frequent activation, and clinical trials evaluating JAK inhibitors (JAKi) in advanced breast cancer are ongoing. Using patient biopsies and preclinical models of breast cancer, we demonstrate that the JAK/STAT pathway is active in metastasis. Unexpectedly, blocking the pathway with JAKi enhances the metastatic burden in experimental and orthotopic models of breast cancer metastasis. We demonstrate that this prometastatic effect is due to the immunosuppressive activity of JAKi with ensuing impairment of NK-cell-mediated anti-tumour immunity. Furthermore, we show that immunostimulation with IL-15 overcomes the enhancing effect of JAKi on metastasis formation. Our findings highlight the importance of evaluating the effect of targeted therapy on the tumour environment. The impact of JAKi on NK cells and the potential value of immunostimulators to overcome the weakened tumour immunosurveillance, are worthwhile considering in the clinical setting of breast cancer.
Dual band metamaterial perfect absorber based on artificial dielectric “molecules”
Authors: Liu Xiaoming , Lan Chuwen , Li Bo , Zhao Qian , Zhou Ji 
Published: July 2016

AbstractDual band metamaterial perfect absorbers with two absorption bands are highly desirable because of their potential application areas such as detectors, transceiver system and spectroscopic imagers. However, most of these dual band metamaterial absorbers proposed were based on resonances of metal patterns. Here, we numerically and experimentally demonstrate a dual band metamaterial perfect absorber composed of artificial dielectric “molecules” with high symmetry. The artificial dielectric “molecule” consists of four “atoms” of two different sizes corresponding to two absorption bands with near unity absorptivity. Numerical and experimental absorptivity verify that the dual-band metamaterial absorber is polarization insensitive and can operate in wide-angle incidence.
Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
Authors: Lee I. Russel , Molton James S. , Wyres Kelly L. , Gorrie Claire , Wong Jocelyn , Hoh Chu Han , Teo Jeanette , Kalimuddin Shirin , Lye David C. , Archuleta Sophia , Holt Kathryn E. , Gan Yunn-Hwen 
Published: July 2016

AbstractHypervirulent Klebsiella pneumoniae is an emerging cause of community-acquired pyogenic liver abscess. First described in Asia, it is now increasingly recognized in Western countries, commonly afflicting those with Asian descent. This raises the question of genetic predisposition versus geospecific strain acquisition. We leveraged on the Antibiotics for Klebsiella Liver Abscess Syndrome Study (A-KLASS) clinical trial ongoing in ethnically diverse Singapore, to prospectively examine the profiles of 70 patients together with their isolates’ genotypic and phenotypic characteristics. The majority of isolates belonged to capsule type K1, a genetically homogenous group corresponding to sequence-type 23. The remaining K2, K5, K16, K28, K57 and K63 isolates as well as two novel cps isolates were genetically heterogeneous. K1 isolates carried higher frequencies of virulence-associated genes including rmpA (regulator of mucoid phenotype A), kfu (Klebsiella ferric uptake transporter), iuc (aerobactin), iro (salmochelin) and irp (yersiniabactin) than non-K1 isolates. The Chinese in our patient cohort, mostly non-diabetic, had higher prevalence of K1 infection than the predominantly diabetic non-Chinese (Malays, Indian and Caucasian). This differential susceptibility to different capsule types among the various ethnic groups suggests patterns of transmission (e.g. environmental source, familial transmission) and/or genetic predisposition unique to each race despite being in the same geographical location.