bluuebunny/crossref_metadata_2025_split huggingface dataset:
Underwater video reveals decreased activity of rocky intertidal snails during high tides and cooler days
Authors: Taylor Austin W. , Morgan Steven G. , Gravem Sarah A. 
Published: April 2017

AbstractNearly all of our understanding of rocky inter‐tidal ecology comes from studies conducted at low tide. To study inter‐tidal organisms at high tide, we anchored waterproof digital GoPro® video cameras in wave‐exposed tidepools and recorded the daytime movements of the black turban snail, Tegula funebralis, over the tidal cycle between May and August 2012 near Bodega Bay, California. Overall, snails moved more quickly and presumably foraged more during low tides and on days with warmer air and perhaps water temperatures. This is similar to other ectotherms that exhibit increased metabolic rates, movement and foraging in warmer conditions. Snails also moved less during flood and high tides, may have moved downward in tidepools at flood tides, and showed evidence of reduced activity on days with larger waves. This inactivity and refuge seeking may have been a strategy to avoid dislodgment by waves. Analysis of snail trajectories showed foraging bouts indicated by alternating zig‐zagging and straight movement. There was no effect of temperature, wave height, or tidal phase on distribution of snail turning angles, suggesting that they may have foraged consistently but moved faster during warm conditions and low tides, thereby grazing a larger area. This is one of few direct recordings of inter‐tidal organisms on wave‐exposed rocky shores during high tide. The methods used here are easily transferable to other studies, which are needed to increase our understanding of behaviors that structure rocky shore communities during high tide.
Conic martingales from stochastic integrals
Authors: Jeanblanc Monique , Vrins Frédéric 
Published: April 2017

AbstractIn this paper, we introduce the concept of conic martingales. This class refers to stochastic processes that have the martingale property but that evolve within given (possibly time‐dependent) boundaries. We first review some results about the martingale property of solution to driftless stochastic differential equations. We then provide a simple way to construct and handle such processes. Specific attention is paid to martingales in [0, 1]. One of these martingales proves to be analytically tractable. It is shown that up to shifting and rescaling constants, it is the only martingale (with the trivial constant, Brownian motion, and geometric Brownian motion) having a separable diffusion coefficient and that can be obtained via a time‐homogeneous mapping of Gaussian diffusions. The approach is exemplified by modeling stochastic conditional survival probabilities in the univariate and bivariate cases.
Optimal cash holdings under heterogeneous beliefs
Authors: Jarrow Robert , Krishenik Andrey , Minca Andreea 
Published: April 2017

AbstractThis paper explores a one‐period model for a firm that finances its operations through debt provided by heterogeneous creditors. Creditors differ in their beliefs about the firm's investment outcomes. We show the existence of Stackelberg equilibria in which the firm holds cash reserves in order to provide incentives for pessimistic creditors to invest in the firm. We find interest rates and cash holdings to be complementary tools for increasing debt capacity. In markets with a high concentration of capital across a small interval of pessimistic creditors or by a few large creditors, cash holdings is the preferred tool to increase the debt capacity of the firm.
The Intergenerational Effect of Cambodia's Genocide on Children's Education and Health
Authors: Islam Asadul , Ouch Chandarany , Smyth Russell , Wang Liang Choon 
Published: April 2017

AbstractWe investigate the intergenerational impact of conflict on the educational and health outcomes of children born years after the conflict ended by exploiting geographical variation in the intensity of the genocide that occurred during the Khmer Rouge (KR) regime in Cambodia. We find that children of individuals who were of prime marriage age during the genocide and experienced greater intensity of genocide have worse educational and health outcomes. In particular, for each standard deviation increase in the intensity of the genocide, average children's normal grade progression rate decreases by 0.03 standard deviations and average children's height‐for‐ age Z‐score decreases by 0.06 standard deviations. We examine several channels through which genocide could affect children born to survivors after the conflict and find suggestive evidence that the marriage market acts as a channel that transmits the adverse impact of conflict across generations. Our findings are robust to alternative measures of mortality rates and post‐KR internal migration.
Renal Replacement Therapy and Incremental Hemodialysis for Veterans with Advanced Chronic Kidney Disease
Authors: Kalantar‐Zadeh Kamyar , Crowley Susan T. , Beddhu Srinivasan , Chen Joline L.T. , Daugirdas John T. , Goldfarb David S. , Jin Anna , Kovesdy Csaba P. , Leehey David J. , Moradi Hamid , Navaneethan Sankar D. , Norris Keith C. , Obi Yoshitsugu , O'Hare Ann , Shafi Tariq , Streja Elani , Unruh Mark L. , Vachharajani Tushar J. , Weisbord Steven , Rhee Connie M. 
Published: April 2017

AbstractEach year approximately 13,000 Veterans transition to maintenance dialysis, mostly in the traditional form of thrice‐weekly hemodialysis from the start. Among >6000 dialysis units nationwide, there are currently approximately 70 Veterans Affairs (VA) dialysis centers. Given this number of VA dialysis centers and their limited capacity, only 10% of all incident dialysis Veterans initiate treatment in a VA center. Evidence suggests that, among Veterans, the receipt of care within the VA system is associated with favorable outcomes, potentially because of the enhanced access to healthcare resources. Data from the United States Renal Data System Special Study Center “Transition‐of‐Care‐in‐CKD” suggest that Veterans who receive dialysis in a VA unit exhibit greater survival compared with the non‐VA centers. Substantial financial expenditures arise from the high volume of outsourced care and higher dialysis reimbursement paid by the VA than by Medicare to outsourced providers. Given the exceedingly high mortality and abrupt decline in residual kidney function (RKF) in the first dialysis year, it is possible that incremental transition to dialysis through an initial twice‐weekly hemodialysis regimen might preserve RKF, prolong vascular access longevity, improve patients’ quality of life, and be a more patient‐centered approach, more consistent with “personalized” dialysis. Broad implementation of incremental dialysis might also result in more Veterans receiving care within a VA dialysis unit. Controlled trials are needed to examine the safety and efficacy of incremental hemodialysis in Veterans and other populations; the administrative and health care as well as provider structure within the VA system would facilitate the performance of such trials.
Phenomenology, Objectivity, and the Explanatory Gap
Authors: Conaill Donnchadh Ó 
Published: April 2017

AbstractThere has been much recent discussion of whether Husserlian phenomenology might be relevant to the explanatory gap—the problem of explaining how conscious experience arises from nonexperiential events or processes. However, some phenomenologists have argued that the explanatory gap is a confused problem, because it starts by assuming a false distinction between the subjective and the objective. Rather than trying to solve this problem, they claim that phenomenology should dissolve it by undermining the distinction upon which it is based. I shall argue that adopting a phenomenological approach does not provide reason to think that the explanatory gap is not a genuine problem. In assessing the assumptions underlying the gap, we must distinguish between objectivity understood as a stance we can take toward the world and objectivity as the world's having a structure independent of any experience. The explanatory gap can be understood as the problem of finding a place for consciousness in this objective structure. This does not force us to take an objective stance or reduce the methods of phenomenology to those of the natural sciences.
The Tactual Ground, Immersion, and the “Space Between”
Authors: Mac Cumhaill Clare 
Published: April 2017

AbstractI ask whether figure‐ground structure can be realized in touch, and, if so, how. Drawing on the taxonomy of touch sketched in Katz's 1925 The World of Touch, I argue that the form of touch that is relevant to such consideration is a species of immersed touch. I consider whether we can feel the space we are immersed in and, more specifically, the empty space against which the surfaces of objects, as I shall urge, “stand out.” Harnessing M. G. F. Martin's account of bodily awareness and touch, I defend a positive thesis, pace Graham Nerlich on whose The Shape of Space (1994) I otherwise rely, both to defend the supposition that empty space can in principle be felt and to argue that touching empty space is not a mere species of absence perception. Along the way, I defuse a causal worry that might be thought to arise in the case of touching empty space.
Evaluation of magnetic resonance imaging for the differentiation of inflammatory, neoplastic, and vascular intradural spinal cord diseases in the dog
Authors: Masciarelli Amanda E. , Griffin John F. , Fosgate Geoffrey T. , Hecht Silke , Mankin Joseph M. , Holmes Shannon P. , Platt Simon R. , Kent Marc , Pancotto Theresa E. , Chen Annie V. , Levine Jonathan M. 
Published: April 2017

AbstractMagnetic resonance imaging (MRI) is a common test for dogs with suspected intradural spinal cord lesions, however studies on diagnostic performance for this test are lacking. Objectives of this multi‐institutional, retrospective, case‐control study were to estimate sensitivity and specificity of MRI for (1) distinguishing between histopathologically confirmed intradural spinal cord disease versus degenerative myelopathy in dogs, (2) categorizing intradural spinal cord diseases as neoplastic, inflammatory, or vascular; and (3) determining tumor type within the etiologic category of neoplasia. Additional aims were to (1) determine whether knowledge of clinical data affects sensitivity and specificity of MRI diagnoses; and (2) report interrater agreement for MRI classification of intradural spinal lesions. Cases were recruited from participating hospital databases over a 7‐year period. Three reviewers independently evaluated each MRI study prior to and after provision of clinical information. A total of 87 cases were sampled (17 degenerative myelopathy, 53 neoplasia, nine inflammatory, and eight vascular). Magnetic resonance imaging had excellent (>97.6%) sensitivity for diagnosis of intradural spinal cord lesions but specificity varied before and after provision of clinical data (68.6% vs. 82.4%, P = 0.023). Magnetic resonance imaging had good sensitivity (86.8%) and moderate specificity (64.7–72.5%) for diagnosing neoplasia. Sensitivity was lower for classifying inflammatory lesions but improved with provision of clinical data (48.1% vs. 81.5%, P = 0.015). Magnetic resonance imaging was insensitive for diagnosing vascular lesions (25.0%). Interrater agreement was very good for correctly diagnosing dogs with intradural lesions (ĸ = 0.882–0.833), and good (ĸ = 0.726–0.671) for diagnosing dogs with neoplasia.
An autocrine ATP release mechanism regulates basal ciliary activity in airway epithelium
Authors: Droguett Karla , Rios Mariana , Carreño Daniela V. , Navarrete Camilo , Fuentes Christian , Villalón Manuel , Barrera Nelson P. 
Published: April 2017

Key points
Extracellular ATP, in association with [Ca2+]i regulation, is required to maintain basal ciliary beat frequency.
Increasing extracellular ATP levels increases ciliary beating in airway epithelial cells, maintaining a sustained response by inducing the release of additional ATP.
Extracellular ATP levels in the millimolar range, previously associated with pathophysiological conditions of the airway epithelium, produce a transient arrest of ciliary activity.
The regulation of ciliary beat frequency is dependent on ATP release by hemichannels (connexin/pannexin) and P2X receptor activation, the blockage of which may even stop ciliary movement.
The force exerted by cilia, measured by atomic force microscopy, is reduced following extracellular ATP hydrolysis. This result complements the current understanding of the ciliary beating regulatory mechanism, with special relevance to inflammatory diseases of the airway epithelium that affect mucociliary clearance.
AbstractExtracellular nucleotides, including ATP, are locally released by the airway epithelium and stimulate ciliary activity in a [Ca2+]i‐dependent manner after mechanical stimulation of ciliated cells. However, it is unclear whether the ATP released is involved in regulating basal ciliary activity and mediating changes in ciliary activity in response to chemical stimulation. In the present study, we evaluated ciliary beat frequency (CBF) and ciliary beating forces in primary cultures from mouse tracheal epithelium, using videomicroscopy and atomic force microscopy (AFM), respectively. Extracellular ATP levels and [Ca2+]i were measured by luminometric and fluorimetric assays, respectively. Uptake of ethidium bromide was measured to evaluate hemichannel functionality. We show that hydrolysis of constitutive extracellular ATP levels with apyrase (50 U ml−1) reduced basal CBF by 45% and ciliary force by 67%. The apyrase effect on CBF was potentiated by carbenoxolone, a hemichannel inhibitor, and oxidized ATP, an antagonist used to block P2X7 receptors, which reduced basal CBF by 85%. Additionally, increasing extracellular ATP levels (0.1–100 μm) increased CBF, maintaining a sustained response that was suppressed in the presence of carbenoxolone. We also show that high levels of ATP (1 mm), associated with inflammatory conditions, lowered basal CBF by reducing [Ca2+]i and hemichannel functionality. In summary, we provide evidence indicating that airway epithelium ATP release is the molecular autocrine mechanism regulating basal ciliary activity and is also the mediator of the ciliary response to chemical stimulation.
Improvement of Performance and Reduction of Fatigue With Low-Level Laser Therapy in Competitive Cyclists
Authors: Lanferdini Fábio J. , Bini Rodrigo R. , Baroni Bruno M. , Klein Kelli D. , Carpes Felipe P. , Vaz Marco A. 
Published: April 2017

Evidence indicates that low-level laser therapy (LLLT) minimizes fatigue effects on muscle performance. However, the ideal LLLT dosage to improve athletes’performance during sports activities such as cycling is still unclear. Therefore, the goal of this study was to investigate the effects of different LLLT dosages on cyclists’performance in time-to-exhaustion tests. In addition, the effects of LLLT on the frequency content of the EMG signals to assess fatigue mechanisms were examined. Twenty male competitive cyclists participated in a crossover, randomized, double-blind, placebo-controlled trial. They performed an incremental cycling test to exhaustion (on day 1) followed by 4 time-to-exhaustion tests (on days 2–5) at their individual maximal power output. Before each time-to-exhaustion test, different dosages of LLLT (135, 270, and 405 J/thigh, respectively) or placebo were applied at the quadriceps muscle bilaterally. Power output and muscle activation from both lower limbs were recorded throughout the tests. Increased performance in time-to-exhaustion tests was observed with the LLLT-135 J (∼22 s; P < .01), LLLT-270 J (∼13 s; P = .03), and LLLT-405 J (∼13 s; P = .02) compared to placebo (149 ± 23 s). Although LLLT-270 J and LLLT-405 J did not show significant differences in muscle activation compared with placebo, LLLT-135 J led to an increased high-frequency content compared with placebo in both limbs at the end of the exhaustion test (P ≤ .03). In conclusion, LLLT increased time to exhaustion in competitive cyclists, suggesting this intervention as a possible nonpharmacological ergogenic agent in cycling. Among the different dosages, LLLT-135 J seems to promote the best effects.
Straight-Line and Change-of-Direction Intermittent Running in Professional Soccer Players
Authors: Fessi Mohamed S. , Farhat Fayçal , Dellal Alexandre , Malone James J. , Moalla Wassim 
Published: April 2017

Purpose:To investigate the difference between straight-line (STL) and change-of-direction (COD) intermittent-running exercises in soccer players.Methods:Seventeen male professional soccer players performed the agility T test and 6 intermittent-running exercises: 10 s at 130% of maximal aerobic speed (MAS) alternated with 10 s of rest (10-10), 15 s at 120% of MAS alternated with 15 s of rest (15-15), and 30 s at 110% of MAS alternated with 30 s of rest (30-30) both in STL and with COD. All exercises were monitored using a global positioning system. Heart rate was measured during exercises, and rating of perceived exertion (RPE) was collected postexercise. The difference (Δ) between covered distance in STL and COD exercises at a similar load was calculated, and relationships between T test and Δ distance were analyzed.Results:COD intermittent exercises showed a significantly decreased distance covered and an increase in the number of accelerations, peak heart rate, and RPE compared with STL intermittent exercises at a similar load. High relationships were observed between T-test performance and Δ distance in 10-10 (r = .72,P < .01) and 15-15 (r = .77,P < .01), whereas no significant relationships were observed between T-test performance and Δ distance in 30-30 (r = −.37,P = .2).Conclusion:Intermittent COD exercises were associated with higher acceleration, peak heart rate, and RPE than STL during 10-10 and 15-15 exercises. The ability to rapidly change direction is crucial to perform intense sport-specific running in professional soccer players.
Alterations in Redox Homeostasis During Recovery From Unexplained Underperformance Syndrome in an Elite International Rower
Authors: Lewis Nathan A. , Redgrave Ann , Homer Mark , Burden Richard , Martinson Wendy , Moore Brian , Pedlar Charles R. 
Published: April 2017

Purpose: To examine a diagnosis of unexplained underperformance syndrome (UUPS, or overtraining syndrome) in an international rower describing a full recovery and return to elite competition the same year. Methods: On diagnosis and 4 and 14 mo postdiagnosis, detailed assessments including physiological, nutritional, and biomarkers were made. Results: Clinical examination and laboratory results for hematology, biochemistry, thyroid function, immunology, vitamins, and minerals were unremarkable and did not explain the presentation and diagnosis. Redox biomarkers including hydroperoxides, plasma antioxidant capacity, red blood cell glutathione, superoxide dismutase, coenzyme Q10, vitamin E (α- and γ-tocopherol), and carotenoids (lutein, α-carotene, β-carotene) provided evidence of altered redox homeostasis. The recovery strategy began with 12 d of training abstinence and nutritional interventions, followed by 6 wk of modified training. At 4 mo postintervention, performance had recovered strongly, resulting in the athlete’s becoming European champion that same year. Further improvements in physiological and performance indices were observed at 14 mo postintervention. Physiologically relevant increases in concentrations of carotenoids were achieved at each postintervention time point, exceeding the reported critical-difference values. Conclusions: Increasing athlete phytonutrient intake may enhance recovery and tolerance of training and environmental stressors, reducing the risk of unexplained UUPS. Alterations in redox homeostasis should be considered as part of the medical management in UUPS. This is the first reported case study of an elite athlete with alterations in redox homeostasis in conjunction with a diagnosis of UUPS.
Combining Activity-Related Behaviors and Attributes Improves Prediction of Health Status in NHANES
Authors: Keadle Sarah Kozey , Bluethmann Shirley , Matthews Charles E. , Graubard Barry I. , Perna Frank M. 
Published: April 2017

Background:This paper tested whether a physical activity index (PAI) that integrates PA-related behaviors (ie, moderate-to-vigorous physical activity [MVPA] and TV viewing) and performance measures (ie, cardiorespiratory fitness and muscle strength) improves prediction of health status.Methods:Participants were a nationally representative sample of US adults from 2011 to 2012 NHANES. Dependent variables (self-reported health status, multimorbidity, functional limitations, and metabolic syndrome) were dichotomized. Wald-F tests tested whether the model with all PAI components had statistically significantly higher area under the curve (AUC) values than the models with behavior or performance scores alone, adjusting for covariates and complex survey design.Results:The AUC (95% CI) for PAI in relation to health status was 0.72 (0.68, 0.76), and PAI-AUC for multimorbidity was 0.72 (0.69, 0.75), which were significantly higher than the behavior or performance scores alone. For functional limitations, the PAI AUC was 0.71 (0.67, 0.74), significantly higher than performance, but not behavior scores, while the PAI AUC for metabolic syndrome was 0.69 (0.66, 0.73), higher than behavior but not performance scores.Conclusions:These results provide empirical support that an integrated PAI may improve prediction of health and disease. Future research should examine the clinical utility of a PAI and verify these findings in prospective studies.
Active Travel Behavior in a Border Region of Texas and New Mexico: Motivators, Deterrents, and Characteristics
Authors: Sener Ipek N. , Lee Richard J. 
Published: April 2017

Background:Active travel has been linked with improved transportation and health outcomes, such as reduced traffic congestion and air pollution, improved mobility, accessibility, and equity, and increased physical and mental health. The purpose of this study was to better understand active travel characteristics, motivators, and deterrents in the El Paso, TX, region.Methods:A multimodal transportation survey brought together elements of transportation and health, with a focus on attitudinal characteristics. The analysis consisted of an initial descriptive analysis, spatial analysis, and multivariate binary and ordered-response models of walking and bicycling behavior.Results:The motivators and deterrents of active travel differed for walkers, bicyclists, and noncyclists interested in bicycling. The link between active travel and life satisfaction was moderated by age, with a negative association for older travelers. This effect was stronger for bicycling than it was for walking.Conclusions:Based on the findings, several interventions to encourage walking and bicycling were suggested. These included infrastructure and built environment enhancements, workplace programs, and interventions targeting specific subpopulations.
Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
Authors: Kim Jun-Seob , Wood Thomas K. 
Published: April 2017

ABSTRACT
There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population.