bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome after laparoscopic and open resections of posterosuperior segments of the liver
Authors: Scuderi V , Barkhatov L , Montalti R , Ratti F , Cipriani F , Pardo F , Tranchart H , Dagher I , Rotellar F , Abu Hilal M , Edwin B , Vivarelli M , Aldrighetti L , Troisi R I 
Published: February 2017

Abstract

Background
Laparoscopic resection of posterosuperior (PS) segments of the liver is hindered by limited visualization and curvilinear resection planes. The aim of this study was to compare outcomes after open and laparoscopic liver resections of PS segments.

Methods
Patients who underwent minor open liver resection (OLR) and laparoscopic liver resection (LLR) between 2006 and 2014 were identified from the institutional databases of seven tertiary referral European hepatobiliary surgical units. Propensity score-matched analysis was used to match groups for known confounders. Perioperative outcomes including complications were assessed using the Dindo–Clavien classification, and the comprehensive complication index was calculated. Survival was analysed with the Kaplan–Meier method.

Results
Some 170 patients underwent OLR and 148 had LLR. After propensity score-matched analysis, 86 patients remained in both groups. Overall postoperative complication rates were significantly higher after OLR compared with LLR: 28 versus 14 per cent respectively (P = 0·039). The mean(s.d.) comprehensive complication index was higher in the OLR group, although the difference was not statistically significant (26·7(16·6) versus 18·3(8·0) in the LLR group; P = 0·108). The mean(s.d.) duration of required analgesia and the median (range) duration of postoperative hospital stay were significantly shorter in the LLR group: 3·0(1·1) days versus 1·6(0·8) days in the OLR group (P &lt; 0·001), and 6 (3–44) versus 4 (1–11) days (P &lt; 0·001), respectively. The 3-year recurrence-free survival rates for patients with hepatocellular carcinoma (37 per cent for OLRversus 30 per cent for LLR; P = 0·534) and those with colorectal liver metastases (36 versus 36 per cent respectively; P = 0·440) were not significantly different between the groups.

Conclusion
LLR of tumours in PS segments is feasible in selected patients. LLR is associated with fewer complications and does not compromise survival compared with OLR.
Sinus septi nasi: Anatomical study
Authors: Mladina Ranko , Antunović Romano , Cingi Cemal , Bayar Muluk Nuray , skitarelić Neven 
Published: February 2017

The aim of this study was to perform a pioneering investigation into the incidence of pneumatization in human skulls. A total of 93 human skulls (≥20 years of age, 69 males, 24 females) were included in the study. The skulls were scanned in a fixed position using cone beam computed tomography (CBCT). The pneumatized space parameters within the nasal septum—width, length, and height—were measured. Two types of finding were identified: (a) Pneumatization, named “sinus septi nasi” (SSN), and (b) “spongy bone” (SB). The results showed SSN in 32 of the 93 skulls (34.4%). The SSN formations were from 0.5 to 4.2 mm wide, 3.5 to 18.8 mm long, and 3.8 to 17.7 mm high. Tumefactions filled with SB were found in 61 of the 93 skulls (65.59%). These were not suitable for precise measurements since the outer borders were not strictly and well defined on CT scans (perhaps because of the preparation process). In conclusion, the perpendicular plate of the ethmoidal bone is not always compact bone; in 34.4% of cases, it shows a degree of pneumatization. In contrast, an enlarged formation filled with SB is present in 65.59% of cases. The possible sources of pneumatization of this little‐investigated region are discussed: sphenoid sinus, frontal sinus, and vomeronasal organ. Clin. Anat. 30:312–317, 2017. © 2017 Wiley Periodicals, Inc.
Insulin‐dependent cytoplasmic distribution of Rab4a in mouse adipocytes is inhibited by interleukin‐6, ‐8, and ‐15
Authors: Błaszczyk Maciej , Gajewska Małgorzata , Milewska Marta , Grzelkowska‐Kowalczyk Katarzyna 
Published: February 2017

AbstractThe purpose of the study was to examine the effect of interleukins, IL‐6, IL‐8, and IL‐15, on insulin‐mediated redistribution of Rab4a, an early endosome marker, in mouse 3T3‐L1 adipocytes. The interleukins did not affect cell viability; however, cell number was slightly but significantly higher in cultures exposed to IL‐8 and IL‐15. IL‐8 and IL‐15 decreased lipid storage in adipocytes, whereas IL‐6 had no effect. Rab4A showed cytoplasmic localization, and in control unstimulated adipocytes it was found primarily nearby nucleus, that was supported by cellular fluorescence distribution profile, and by calculated indices, that is, high percentage of near‐nuclear area fluorescence and a low mean peripheral cytoplasmic fluorescence/mean near‐nuclear fluorescence ratio. Insulin stimulation (100 nmol/l, 30 min) altered the cytoplasmic localization of Rab4a in control adipocytes, which was manifested by its redistribution towards plasma membrane. This effect of insulin was prevented in adipocytes exposed to IL‐6, IL‐8, or IL‐15. We concluded that insulin‐dependent Rab4a redistribution, probably reflecting stimulation of vesicle‐mediated transport, is inhibited in adipocytes subjected to differentiation in the presence of IL‐6, IL‐8, or IL‐15. Such alterations may be involved in the mechanisms contributing to development of insulin resistance associated with inflammation; however, further studies in this field are required.
Endovascular therapy for Angio‐sealTM‐related acute limb ischemia: Perioperative and long‐term results
Authors: Dong Hui , Peng Meng , Jiang Xiongjing , Che Wuqiang , Zou Yubao , Xu Bo , Yang Yuejin , Gao Runlin 
Published: February 2017

ObjectivesTo investigate the perioperative and long‐term outcomes of endovascular therapy for Angio‐sealTM‐related acute limb ischemia.BackgroundCurrently, limited data are available on the optimal treatment strategy for Angio‐sealTM‐related acute lower limb ischemia.MethodsThe prospectively maintained patient database of our institution was retrospectively searched to identify all patients who developed acute lower limb ischemia after use of the Angio‐SealTM and received endovascular treatment from January 2010 to February 2016. The clinical and follow‐up data were evaluated.ResultsThirty‐two patients with Angio‐SealTM‐related acute limb ischemia underwent endovascular therapy, resulting in an approximated incidence of 0.29% of all implanted devices. The overall procedural success rate was 96.9%. With regard to the patients who underwent successful endovascular treatment, the culprit lesion was located in the common femoral artery in 22 (71.0%) cases, the femoral artery bifurcation in 3 (9.7%) cases and the superficial femoral artery in 6 (19.4%) cases. Ten (31.3%) patients had thrombosis in other distal lower limb arteries ipsilateral to Angio‐sealTM use. Eighteen (58.1%) patients underwent balloon angioplasty alone, while nine (29.0%) patients underwent balloon angioplasty and thrombolysis, and four (12.9%) patients underwent stent implantation. One patient suffered from minor bleeding at the site of application of the Angio‐sealTM. During an average of 43.5 ± 22.9 months of follow‐up, three patients with symptomatic restenosis underwent a second successful balloon angioplasty and remained asymptomatic until the last follow‐up.ConclusionsBalloon angioplasty with selective thrombolysis or stent placement was safe and effective, with a low incidence of complication and restenosis. © 2017 Wiley Periodicals, Inc.
Tissue characterization and phenotype classification in patients presenting with acute myocardial infarction: Insights from the iWonder study
Authors: Souza Cristiano F. , Maehara Akiko , Mintz Gary S. , Matsumura Mitsuaki , Alves Claudia M.R. , Carlos Carvalho Antonio , Caixeta Adriano 
Published: February 2017

ObjectivesWe sought to assess a new modality of radiofrequency intravascular ultrasound (IVUS) called iMAP‐IVUS (Boston Scientific, Santa Clara, California) during the evaluation of patients presenting with high‐risk acute coronary syndromes.BackgroundThere are limited data on plaque tissue characterization and phenotype classification using iMAP‐IVUS.MethodsIn the iWonder study patients presenting with ST‐elevation myocardial infarction (STEMI) or non‐STEMI underwent three‐vessel grayscale IVUS and iMAP‐IVUS tissue characterization prior to percutaneous intervention. In total 385 lesions from 100 patients were divided into culprit (n = 100) and nonculprit (n = 285) lesions. Lesion phenotype was classified as (i) thin‐cap fibroatheroma (iMAP‐derived TCFA); (ii) thick‐cap fibroatheroma; (iii) pathological intimal thickening; (iv) fibrotic plaque; and (v) fibrocalcific plaque.ResultsCulprit lesions had smaller minimum lumen cross‐sectional area (MLA) with greater plaque burden compared to non‐culprit lesions. Volumetric analysis showed that culprit lesions had longer length and larger vessel and plaque volumes compared to non‐culprit lesions. iMAP‐IVUS revealed that culprit lesions presented more NC and fibrofatty volume, both at lesion level and at the MLA site (all P < 0.001). Any fibroatheroma was more frequently identified in culprit lesions compared with non‐culprit lesions (93% vs. 78.9%, P = 0.001), anywhere within the lesion 19.0%, P < 0.001) as well as at the MLA site (18.0% vs. 9.5%, P = 0.07).ConclusionsThree‐vessel radiofrequency iMAP‐IVUS demonstrated a greater plaque burden and higher prevalence of any fibroatheroma as well as iMAP‐derived TCFAs in culprit versus non‐culprit lesions in patients presenting with STEMI or non‐STEMI undergoing percutaneous coronary intervention. © 2017 Wiley Periodicals, Inc.
Harnessing a p‐Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20‐Deoxy‐Elansolid B1
Authors: Wang Liang Liang , Candito David , Dräger Gerald , Herrmann Jennifer , Müller Rolf , Kirschning Andreas 
Published: February 2017

AbstractThe polyketide, 20‐deoxy elansolid B1, was prepared by a convergent strategy that relied on a putative biomimetic intramolecular Diels–Alder cycloaddition (IMDA) via a vinylic p‐quinone methide intermediate to furnish the key tetrahydroindane unit. The (Z,E,Z)‐configured triene unit was constructed by Pd‐catalyzed Suzuki–Miyaura and Stille cross‐coupling reactions without isomerization of any of the olefinic double bonds. Formation of a p‐methide quinone intermediate under basic conditions and subsequent Michael addition by water to this intermediate proceeded with high facial selectivity which terminated this total synthesis. Remarkably, the new elansolid derivative 2 c shows very good inhibitory effect against Bacillus subtilis and Staphylococcus aureus (including MRSA) similarly to the best elansolid derivatives reported so far. Consequently, the hydroxyl group at C20 is not essential for antibacterial activity.
Zn2+‐Ion Sensing by Fluorescent Schiff Base Calix[4]arene Macrocycles
Authors: Ullmann Steve , Schnorr René , Handke Marcel , Laube Christian , Abel Bernd , Matysik Jörg , Findeisen Matthias , Rüger Robert , Heine Thomas , Kersting Berthold 
Published: February 2017

AbstractA macrocyclic ligand (H2L) containing two o,o′‐bis(iminomethyl)phenol and two calix[4]arene head units has been synthesized and its coordination chemistry towards divalent Ni and Zn investigated. The new macrocycle forms complexes of composition [ML] (M=Zn, M=Ni) and [ZnL(py)2], which were characterized by elemental analysis; IR, UV/Vis, and NMR spectroscopy; electrospray ionization mass spectrometry (ESI‐MS); and X‐ray crystallography (for [ZnL(py)2] and [NiL]). H2L allows the sensitive optical detection of Zn2+ among a series of biologically relevant metal ions by a dual fluorescence enhancement/quenching effect in solution. The fluorescence intensity of the macrocycle increases by a factor of ten in the presence of Zn2+ with a detection limit in the lower nanomolar region.
co.labore—A Genuine Collaboration between Arts and Science, Reflecting Viewpoints and Merging Skills
Authors: Rakers Lena , Tebben Ludger , Glorius Frank 
Published: February 2017

AbstractOften chemists regard their scientific work as creative, when designing and synthesizing new molecules and larger assemblies. In this, we have to go through recurring stages of planning projects, doubting results, discarding ideas, and restarting them with a different approach in order to be successful in chemical research. From this point of view, can we fairly assume that these processes are analogous to the stages artists go through when creating art? In our efforts to strengthen reflective perspectives on what chemists are doing, the SFB 858 initiated a collaboration with the Academy of Fine Arts Münster. Additionally, we were aiming to enter into a dialogue about our research with a broader public.
Photophysical Enhancement of Triplet Emitters by Coordination‐Driven Self‐Assembly
Authors: Zhang Yuzhen , Fulong Cressa Ria P. , Hauke Cory E. , Crawley Matthew R. , Friedman Alan E. , Cook Timothy R. 
Published: February 2017

AbstractThe quantum yields of organic fluorophores used as donors in coordination‐driven self‐assembly often suffer from the heavy atom effect of nearby metal sites. Here, the role of intersystem crossing from a deactivating process to one that delivers emissive triplet states was reversed. A phosphorescent trans bis‐N‐heterocyclic carbene platinum(II) compound, Pt(dhim)2(C≡C‐4‐py)2 (D1; dhim=1,3‐dihexyl‐2‐H‐imidazol‐2‐ylidene), was used along with other linear donors 4,4′‐bipyridine (D2) and 1,4‐bis(4‐pyridyl ethynyl)benzene (D3) in self‐assembly reactions with Pt(dtbpy)X2 acceptors (dtbpy=4,4′‐di‐tert‐butyl‐2,2′‐bipyridine) to afford three metallacycles. Photophysical investigations revealed that, although the building blocks used to construct M1 have relatively low quantum yields (Φ=1.2 and <1 % for D1 and 2, respectively), the metallacycle has a quantum yield of 14 %. This increase reflects a change in radiative rate constant from 3.6×104 s−1 for D1 to 2.1×105 s−1 for M1.
The influence of chemotherapy on the right ventricle: did we forget something?
Authors: Tadic Marijana , Cuspidi Cesare , Hering Dagmara , Venneri Lucia , Danylenko Oleksandr 
Published: February 2017

BackgroundA large number of chemotherapy‐induced cardiovascular complications were discovered in studies over the last several decades. The focus of the majority of these studies was left ventricular (LV) remodeling. The aim of this article was to provide a comprehensive overview of potential mechanisms of chemotherapy‐induced right ventricular (RV) remodeling and summarize clinical studies on this topic.HypothesisChemotherapy induces RV structural, functional, and mechanical changes.MethodsWe searched PubMed, MEDLINE, Ovid and Embase databases for studies published from January 1990 up to September 2016 in the English language using the following keyword “chemotherapy,” “heart,” “right ventricle,” “anthracyclines,” and “trastuzumab.”ResultsThe existing research show that RV remodeling occurs simultaneously with LV remodeling, which is why RV remodeling should not be neglected in the overall cardiac assessment of patients treated with chemotherapy, and especially those protocols that involve anthracyclines and trastuzumab. Investigations showed that these agents could significantly impact RV structure, function, and mechanics. These medications induce fibrosis of the RV myocardium, RV dilatation, decline in RV systolic function, worsening of its diastolic function, and finally impairment of RV mechanics (strain). The mechanisms of chemotherapy‐induced RV remodeling are still not entirely clear, but it is considered that direct destructive influence of chemotherapy on myocardium, oxidative stress, endothelial dysfunction, and negative impact on pulmonary circulation could significantly contribute to RV impairment.ConclusionsChemotherapy induces the impairment of RV structure, function, and mechanics by different complex mechanisms.
Integrating next‐generation sequencing into pediatric oncology practice: An assessment of physician confidence and understanding of clinical genomics
Authors: Johnson Liza‐Marie , Valdez Jessica M. , Quinn Emily A. , Sykes April D. , McGee Rose B. , Nuccio Regina , Hines‐Dowell Stacy J. , Baker Justin N. , Kesserwan Chimene , Nichols Kim E. , Mandrell Belinda N. 
Published: February 2017

BACKGROUNDThe incorporation of genomic testing to identify targetable somatic alterations and predisposing germline mutations into the clinical setting is becoming increasingly more common. Despite its potential usefulness, to the authors' knowledge physician confidence with regard to understanding and applying genomic testing remains unclear, particularly within the realm of pediatric oncology.METHODSBefore initiating an institutional feasibility study regarding the integration of clinical genomic testing, the authors surveyed pediatric oncologists regarding their confidence around understanding of genomic testing, perceived usefulness of test results, preferences around the disclosure of germline test results, and possible risks and benefits of testing.RESULTSAmong survey respondents (52 of 88 contacted; response rate of 59%), only a minority were confident in interpreting, using, and discussing somatic (35%) or germline (27%) genomic test results. Providers who were confident in interpreting somatic results were significantly more likely to anticipate using the results to plan the treatment of patients with relapsed or refractory cancers (P = .009). Similarly, providers who reported confidence in interpreting germline results were significantly more likely to discuss and use these results as part of clinical care (P<.0001). The majority of physicians (93%), regardless of their level of confidence, wanted to speak to a genetic counselor before disclosing germline test results.CONCLUSIONSAmong physicians at a comprehensive pediatric cancer center, confidence in the interpretation, use, and discussion of oncology‐based genomic test results appears to be low, both in terms of somatic and germline testing. To optimize the integration of genomic sequencing into cancer care, methods must be developed to improve basic competencies around cancer‐based genomic testing. Given the complexities surrounding variant interpretation and genotype‐phenotype relationships, interdisciplinary collaborations are warranted. Cancer 2017;123:2352–2359. © 2017 American Cancer Society.
Smokers with chronic myeloid leukemia are at a higher risk of disease progression and premature death
Authors: Lauseker Michael , Hasford Joerg , Saussele Susanne , Kremers Stephan , Kraemer Doris , Lindemann Walter , Hehlmann Rüdiger , Pfirrmann Markus ,   for the German CML Study Group
Published: February 2017

BACKGROUNDSmoking is suspected to not only be a risk factor for chronic myeloid leukemia but an adverse prognostic factor for the disease as well. The objective of the current study was to investigate the impact of smoking on survival and progression to advanced phases of disease.METHODSBased on the data of the German CML Study IV, the authors analyzed the effect of smoking using a multivariate Cox model with the addition of the European Treatment and Outcome Study (EUTOS) long‐term survival score variables of age, spleen size, thrombocytes, and peripheral blasts as well as sex, comorbidities, and type of treatment center.RESULTSThe 8‐year survival probability was 87% for a nonsmoking patient and 83% for a patient who smoked. The authors noted a 2.08‐times higher risk of death for smokers in comparison with nonsmokers and a 2.11‐times higher cause‐specific hazard of disease progression. An interaction between smoking and age was found in the model for survival. No significant difference with regard to molecular response was observed.CONCLUSIONSEven when considering differences in socioeconomic status and lifestyle between patients who smoke and nonsmokers, the current analysis demonstrated that smoking also might affect disease biology. The results of the current study indicate that patients with chronic myeloid leukemia, in particular those aged <60 years, should be encouraged to quit smoking. Cancer 2017;123:2467–71. © 2017 American Cancer Society.
Strong “bottom‐up” influences on small mammal populations: State‐space model analyses from long‐term studies
Authors: Flowerdew John R. , Amano Tatsuya , Sutherland William J. 
Published: February 2017

Abstract“Bottom‐up” influences, that is, masting, plus population density and climate, commonly influence woodland rodent demography. However, “top‐down” influences (predation) also intervene. Here, we assess the impacts of masting, climate, and density on rodent populations placed in the context of what is known about “top‐down” influences. To explain between‐year variations in bank vole Myodes glareolus and wood mouse Apodemus sylvaticus population demography, we applied a state‐space model to 33 years of catch‐mark‐release live‐trapping, winter temperature, and precise mast‐collection data. Experimental mast additions aided interpretation. Rodent numbers in European ash Fraxinus excelsior woodland were estimated (May/June, November/December). December–March mean minimum daily temperature represented winter severity. Total marked adult mice/voles (and juveniles in May/June) provided density indices validated against a model‐generated population estimate; this allowed estimation of the structure of a time‐series model and the demographic impacts of the climatic/biological variables. During two winters of insignificant fruit‐fall, 6.79 g/m2 sterilized ash seed (as fruit) was distributed over an equivalent woodland similarly live‐trapped. September–March fruit‐fall strongly increased bank vole spring reproductive rate and winter and summer population growth rates; colder winters weakly reduced winter population growth. September–March fruit‐fall and warmer winters marginally increased wood mouse spring reproductive rate and September–December fruit‐fall weakly elevated summer population growth. Density dependence significantly reduced both species' population growth. Fruit‐fall impacts on demography still appeared after a year. Experimental ash fruit addition confirmed its positive influence on bank vole winter population growth with probable moderation by colder temperatures. The models show the strong impact of masting as a “bottom‐up” influence on rodent demography, emphasizing independent masting and weather influences; delayed effects of masting; and the importance of density dependence and its interaction with masting. We conclude that these rodents show strong “bottom‐up” and density‐dependent influences on demography moderated by winter temperature. “Top‐down” influences appear weak and need further investigation.