bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing CDOM Spectral Variability Across Diverse Regions and Spectral Ranges
Authors: Grunert Brice K. , Mouw Colleen B. , Ciochetto Audrey B. 
Published: December 2017

AbstractSatellite remote sensing of colored dissolved organic matter (CDOM) has focused on CDOM absorption (aCDOM) at a reference wavelength, as its magnitude provides insight into the underwater light field and large‐scale biogeochemical processes. CDOM spectral slope, SCDOM, has been treated as a constant or semiconstant parameter in satellite retrievals of aCDOM despite significant regional and temporal variabilities. SCDOM and other optical metrics provide insights into CDOM composition, processing, food web dynamics, and carbon cycling. To date, much of this work relies on fluorescence techniques or aCDOM in spectral ranges unavailable to current and planned satellite sensors (e.g., <300 nm). In preparation for anticipated future hyperspectral satellite missions, we take the first step here of exploring global variability in SCDOM and fit deviations in the aCDOM spectra using the recently proposed Gaussian decomposition method. From this, we investigate if global variability in retrieved SCDOM and Gaussian components is significant and regionally distinct. We iteratively decreased the spectral range considered and analyzed the number, location, and magnitude of fitted Gaussian components to understand if a reduced spectral range impacts information obtained within a common spectral window. We compared the fitted slope from the Gaussian decomposition method to absorption‐based indices that indicate CDOM composition to determine the ability of satellite‐derived slope to inform the analysis and modeling of large‐scale biogeochemical processes. Finally, we present implications of the observed variability for remote sensing of CDOM characteristics via SCDOM.
Biological subtypes and survival outcomes in breast cancer patients with brain metastases in the targeted therapy era
Authors: Bastos Dhiego Chaves de Almeida , Maldaun Marcos Vinicius Calfat , Sawaya Raymond , Suki Dima , Lang Frederick F , Brown Paul D , Rao Ganesh , Weinberg Jeffrey S , Prabhu Sujit S 
Published: December 2017

Abstract

Background
There is recognition that breast cancer is a collection of heterogeneous diseases divided in subtypes based on combined molecular features such as hormonal receptors (HR) and human epidermal growth factor receptor 2 (HER2) status. We aimed to study clinical differences among biological subtypes in brain metastasis from breast cancer after targeted therapy introduction.

Methods
This was a retrospective study with 406 consecutive patients with brain metastasis from breast cancer treated at MD Anderson Cancer Center from 1998 to 2013. Overall, 315 of these patients met the study criteria and were analyzed. Subtypes were classified as HER2-/HR+ (96 patients), HER2+/HR+ (57 patients), HER2+/HR- (63 patients), and triple negative (HER2-/HR-) (99 patients). End points were time to development of brain metastasis (TDBM), brain metastasis-free survival (BMFS), and overall survival from start of treatment of brain metastasis (OSBM). Univariate and multivariate Cox proportional hazard regression models were used to analyze the data.

Results
TDBM was 41 months for HER2-/HR+; 58 months for HER2+/HR+; 30 months for HER2+/HR-; and 27 months for triple negative (P < .001). BMFS was 9 months for HER2-/HR+; 24 months for HER2+/HR+; 9 months for HER2+/HR-; and 7 months for triple negative (P = .06). OSBM was 20 months for HER2-/HR+; 22 months for HER2+/HR+; 24 months for HER2+/HR-; and 9 months for triple negative (P < .001). On multivariate analyses, triple negative showed lower OSBM compared with other subtypes, with a hazard ratio of 1.9 (P < .001).

Conclusion
Comparing all breast cancer subgroups we noticed that HR and HER2 are the most significant biomarkers in brain metastasis behavior. Patients who received targeted therapy had better outcomes, but not in the triple negative group. Prospective studies with different treatment modalities for each subgroup are recommended.
Supporting Faculty During Pedagogical Change Through Reflective Teaching Practice
Authors: Armstrong Deborah K. , Asselin Marilyn E. 
Published: December 2017

Abstract
Given the recent calls for transformation of nursing education, it is critical that faculty be reflective educators. Reflective teaching practice is a process of self-examination and self-evaluation to gain insight into teaching to improve the teaching-learning experience. Limited attention has been given to this notion in the nursing education literature. An innovative reflective teaching practice approach for nursing education is proposed, consisting of question cues, journaling, and a process of facilitated meetings. The authors describe their perceptions of using this approach with faculty during the implementation of a new pedagogy and suggest areas for further research.
Improving Student Receptivity to Abortion Care Education
Authors: Gingrich Pat Mahaffee 
Published: December 2017

Abstract
Letting nursing students develop resilience in the presence of moral complexity improves compassionate patient care for women contemplating abortion. Nursing education needs to include quality materials on abortion care in order to create educated providers and citizens. Some students are resistant or conflicted about this topic. A preclass optional, anonymous survey allows students the opportunity to voice concerns about this sensitive topic and guides the instructor in designing class materials. Resulting classroom dialogue is less heated and more collegial, enabling students to examine and process this complex professional practice issue and practice navigating ethical dilemmas.
Evaluating Cultural Competency Concepts Using Program Theory-Driven Evaluation Framework
Authors: Peer Nancy 
Published: December 2017

Abstract
Research has shown that there is no consistent method of teaching cultural competence or incorporating it into nursing curricula. Thus, nursing programs are at risk for misinterpretation or not meeting required program outcomes or accreditation standards. Although considered social research, program theory-driven evaluation has been cited as an acceptable evaluation method for nursing programs. This research looks at program inputs and program outputs to establish congruency with accreditation standards and to ensure validity and reliability of future research on cultural competency levels of nursing graduates.
Use of Multidirectional Cranial Distraction Osteogenesis for Cranial Expansion in Syndromic Craniosynostosis
Authors: Sunaga Ataru , Sugawara Yasushi , Kamochi Hideaki , Gomi Akira , Uda Hirokazu , Sarukawa Shunji , Yoshimura Kotaro 
Published: December 2017

Summary:
Patients with syndromic craniosynostosis often require a large amount of cranial expansion to avoid intracranial hypertension, but the surgical procedure remains controversial. A patient of severe syndromic craniosynostosis with multiple bony defects and anomalous venous drainage at the occipital region was treated by multidirectional cranial distraction osteogenesis (MCDO) at the age of 8 months. Distraction started 5 days after surgery and ceased on postoperative day 16. The distraction devices were removed 27 days after completing distraction. After device removal, the increase of intracranial volume was 155 ml and the cephalic index was improved from 115.5 to 100.5. The resultant cranial shape was well maintained with minimal relapse at postoperative 9 months. In cases of syndromic craniosynostosis with multiple bony defects and/or anomalous venous drainage at the occipital region, expansion of the anterior cranium by MCDO is a viable alternative to conventional methods.
A Giant Neurovascular Lower Limb Fillet Flap Can Simultaneously Cover Pelvic and Abdominal Defects
Authors: Osinga Rik , Nowakowski Andrej , Isaak Andrej , Schaefer Dirk J. , Fulco Ilario 
Published: December 2017

Summary:
The first description of simultaneous pelvic and abdominal soft-tissue reconstruction with a giant lower limb fillet flap after hip exarticulation and open abdomen is presented. The unfortunate circumstances of a 67-year-old female patient are described leading to soft-tissue necrosis over a periprosthetic femur fracture and open abdomen after emergency implantation of an aortic bifemoral Y-prosthesis because of thrombotic obliteration of the aortic bifurcation. After removal of the hip prosthesis, the neurovascular pedicled myocutaneous fillet flap of the entire left leg was raised and folded proximally at the level of the exarticulated joint of the hip and set into the pelvic and abdominal defect. A giant pedicled neurovascular myocutaneous fillet flap raised over the entire lower extremity is a safe, effective, durable, and sensation-preserving treatment to reconstruct combined pelvic and abdominal soft-tissue defects.
Risk Factors of Inadequate Colposcopy After Large Loop Excision of the Transformation Zone: A Prospective Cohort Study
Authors: Carcopino Xavier , Mancini Julien , Gondry Jean , Chevreau Julien , Lamblin Gery , Atallah Anthony , Lavoue Vincent , Caradec Claire , Baldauf Jean-Jacques , Bryand Angélique , Henno Sebastien , Agostini Aubert , Douvier Serge , Jarniat Adelaïde , Riethmuller Didier , Mendel Anne , Brun Jean-Luc , Rakotomahenina Hajanirina , Preaubert Lise 
Published: December 2017

Objective
The aim of the study was to identify the risk factors of post–large loop excision of the transformation zone (LLETZ) inadequate colposcopy.

Materials and Methods
From December 2013 to July 2014, a total of 157 patients who had a LLETZ performed for the treatment of high-grade intraepithelial lesion with fully visible cervical squamocolumnar junction were included. All procedures were performed using semicircular loops. The use of colposcopy made during each procedure was systematically documented. Dimensions and volume of LLETZ specimens were measured at the time of procedure, before formaldehyde fixation. All participants were invited for a follow-up colposcopy 3 to 6 months after LLETZ. Primary end point was the diagnosis of post-LLETZ inadequate colposcopy, defined by a not fully visible cervical squamocolumnar junction and/or cervical stenosis.

Results
Colposcopies were performed in a mean (SD) delay of 136 (88) days and were inadequate in 22 (14%) cases. Factors found to significantly increase the probability of post-LLETZ inadequate colposcopy were a history of previous excisional cervical therapy [adjusted odds ratio (aOR) = 4.29, 95% CI = 1.12–16.37, p = .033] and the thickness of the specimen (aOR = 3.12, 95% CI = 1.02–9.60, p = .047). The use of colposcopy for the guidance of LLETZ was statistically associated with a decrease in the risk of post-LLETZ inadequate colposcopy (aOR = 0.19, 95% CI = 0.04–0.80, p = .024) as the achievement of negative endocervical margins (aOR = 0.26, 95% CI = 0.08–0.86, p = .027).

Conclusions
Although the risk of post-LLETZ inadequate colposcopy is increased in patients with history of excisional therapy and with the thickness of the excised specimen, it could be reduced with the use of colposcopic guidance and the achievement of negative endocervical margins.
An accurate and rapid continuous wavelet dynamic time warping algorithm for unbalanced global mapping in nanopore sequencing
Authors: Han Renmin , Li Yu , Wang Sheng , Gao Xin 
Published: December 2017

AbstractLong-reads, point-of-care, and PCR-free are the promises brought by nanopore sequencing. Among various steps in nanopore data analysis, the global mapping between the raw electrical current signal sequence and the expected signal sequence from the pore model serves as the key building block to base calling, reads mapping, variant identification, and methylation detection. However, the ultra-long reads of nanopore sequencing and an order of magnitude difference in the sampling speeds of the two sequences make the classical dynamic time warping (DTW) and its variants infeasible to solve the problem. Here, we propose a novel multi-level DTW algorithm, cwDTW, based on continuous wavelet transforms with different scales of the two signal sequences. Our algorithm starts from low-resolution wavelet transforms of the two sequences, such that the transformed sequences are short and have similar sampling rates. Then the peaks and nadirs of the transformed sequences are extracted to form feature sequences with similar lengths, which can be easily mapped by the original DTW. Our algorithm then recursively projects the warping path from a lower-resolution level to a higher-resolution one by building a context-dependent boundary and enabling a constrained search for the warping path in the latter. Comprehensive experiments on two real nanopore datasets on human and on Pandoraea pnomenusa, as well as two benchmark datasets from previous studies, demonstrate the efficiency and effectiveness of the proposed algorithm. In particular, cwDTW can almost always generate warping paths that are very close to the original DTW, which are remarkably more accurate than the state-of-the-art methods including Fast-DTW and PrunedDTW. Meanwhile, on the real nanopore datasets, cwDTW is about 440 times faster than FastDTW and 3000 times faster than the original DTW. Our program is available at https://github.com/realbigws/cwDTW.
‘I guess I do have to take back what I said before, about television’: pregnant women's understandings and use of televisual representations of childbearing
Authors: Bessett Danielle , Murawsky Stef 
Published: December 2017

AbstractResearch on television as a source of childbearing information is divided on its importance. Drawing from a sample of 64 pregnant women in the greater New York and Connecticut metropolitan area, we examine how women understand the influence of television on their expectations for pregnancy and birth. A sizable minority (44%) regularly watched reality television programmes on childbearing; all engaged in active viewing practices, such as recognising programme formula and evaluating plausibility of depictions. We find clear educational differences in how viewers believed television influenced their pregnancy knowledge: women with higher levels of education generally disavowed all television as an information source, but used reality programming to educate their children about pregnancy and for entertainment. Women who had lower educational attainment were more likely to include reality programmes as part of their comprehensive approach to information gathering. Only one woman asserted that fictional television was a good source of pregnancy information. Although many devalued television, women referenced television programmes and imagery as they described their expectations and concerns for pregnancy. A large proportion of respondents were unaware of the influence television exerted on them. Health scholars must better engage with the complexities of media use.
Estimating the drink driving attributable fraction of road traffic deaths in Mexico
Authors: Santoyo‐Castillo Dzoara , Pérez‐Núñez Ricardo , Borges Guilherme , Híjar Martha 
Published: December 2017

AbstractAimTo estimate the Drink Driving Attributable Fraction (DDAF) of road traffic injury mortality in car occupants in Mexico during 2010–13.DesignA case–control study was conducted to examine the presence of alcohol in analysed body fluids of car occupants killed in fatal crashes (cases) compared with car drivers tested in alcohol‐testing checkpoints who were not involved in a fatal collision (controls). Two data sets were used for the period 2010–13: the forensic module of the Epidemiological Surveillance System on Addictions that included car occupants killed in a collision (cases) and a data set from alcohol‐testing at police checkpoints available for matching municipalities (controls).SettingMexico.ParticipantsThe analysed study sample included 1718 car occupants killed in a traffic collision and 80 656 drivers tested at alcohol police checkpoints, all from 10 municipalities.MeasurementsUnadjusted and adjusted odds ratios (OR) of presence of alcohol in body fluids were obtained stratified by sex and age groups and the interaction with these two variables were assessed. The ORs were used to calculate the DDAF.FindingsIt was estimated that 19.5% of car occupants’ deaths due to road traffic injuries were attributable to alcohol consumption [95% confidence interval (CI) = 19.1–19.9]. The adjusted OR of presence of alcohol was 6.84 (95% CI = 6.06–7.71) overall. For males it was 7.21 (95% CI = 6.35–8.18) and for females it was 4.45 (95% CI = 3.01–6.60). The ORs were similar across younger age bands (10–19 years: 9.61, 95% CI = 6.72–13.73; 20–29 years: 7.70, 95% CI = 6.28–9.4; and 30–49 years: 7.21, 95% CI = 5.98–8.70); and lower but still elevated among older people (50+ years: 3.19, 95% CI = 2.19–4.65).ConclusionsAn estimated 19.5% of car occupant deaths in Mexico may have been caused by alcohol in 2010–13.
Differential serum cytokine profile in patients with systemic lupus erythematosus and posterior reversible encephalopathy syndrome
Authors: Merayo-Chalico J , Barrera-Vargas A , Juárez-Vega G , Alcocer-Varela J , Arauz A , Gómez-Martín D 
Published: December 2017

Summary
Systemic lupus erythematosus (SLE) patients are susceptible to the development of posterior reversible encephalopathy syndrome (PRES). The main theory concerning the physiopathology of PRES suggests that there is brain–blood barrier damage, which is associated with endothelial dysfunction, and characterized by vasogenic oedema. However, current evidence regarding its physiopathogenic mechanisms is quite scant. The aim of this study was to analyse the expression of different serum cytokines, as well as vascular endothelial growth factor (VEGF) and soluble CD40 ligand (sCD40L), in patients with PRES/systemic lupus erythematosus (SLE) and to compare them with levels in SLE patients without PRES and in healthy controls. We performed a transversal study in a tertiary care centre in México City. We included 32 subjects (healthy controls, n = 6; remission SLE, n = 6; active SLE, n = 6 and PRES/SLE patients, n = 14). PRES was defined as reversible neurological manifestations (seizures, visual abnormalities, acute confusional state), associated with compatible changes by magnetic resonance imaging (MRI). Serum samples were obtained during the first 36 h after the PRES episode and were analysed by cytometric bead array, Luminex multiplex assay or enzyme-linked immunosorbent assay (ELISA). Interleukin (IL)-6 and IL-10 levels were significantly higher in PRES/SLE patients (P = 0·013 and 0·025, respectively) when compared to the other groups. Furthermore, IL-6 and IL-10 levels displayed a positive correlation (r = 0·686, P = 0·007). There were no differences among groups regarding other cytokines, sCD40L or VEGF levels. A differential serum cytokine profile was found in PRES/SLE patients, with increased IL-6 and IL-10 levels. Our findings, which are similar to those described in other neurological manifestations of SLE, support the fact that PRES should be considered among the SLE-associated neuropsychiatric syndromes.
The level of physical training modulates cytokine levels through P2X7 receptor in healthy subjects
Authors: Comassi Mario , Santini Eleonora , Rossi Chiara , Vitolo Edoardo , Seghieri Marta , Tocchini Leonardo , Franzoni Ferdinando , Solini Anna 
Published: December 2017

AbstractIntroductionThe P2X7 receptor‐NLRP3 inflammasome complex (P2X7R‐Infl) regulates inflammatory and immune responses. Physical exercise modulates heat‐shock proteins (Hsps), influencing cytokine levels and oxidative stress; Hsp72 triggers P2X7R‐Infl‐dependent responses.Subjects and MethodsWe studied the effect of a single bout of maximal exercise on lymphomonocyte expression of P2X7R, NLRP3, caspase‐1, NF‐kB and Hsp72 and circulating levels of IL‐1β, IL‐18 and MCP‐1, all modulated by P2X7R‐Infl, in healthy sedentary (SED), trained (ATH), endurance (END) male individuals.ResultsBaseline P2X7R, NLRP3 and Caspase‐1 expression progressively increased from SED to ATH and END; NF‐kβ showed the same trend. Hsp72 did not differ among groups. Acute exercise strongly reduced P2X7R in all participants, irrespective of their degree of physical training. Inflammasome responses differed across groups: in SED, NLRP3 and Caspase‐1 increased; in ATH, NLRP3 reduced and caspase‐1 did not vary; in END, NLRP3 and Caspase‐1 declined. Baseline IL‐1β, higher in END, was unmodified after exercise; IL‐18 decreased; MCP‐1 doubled in SED, did not vary in ATH, declined in END. In the whole study population, significant direct relationships emerged between P2X7R expression and IL‐1β, IL‐18, MCP‐1 levels, all P < .001; also Caspase‐1 related with these markers. A multivariate analysis showed age, BMI and P2X7R as determinants of postexercise IL‐1β levels.ConclusionEndurance show higher P2X7R‐Infl expression and function vs SED and ATH; however, maximal exercise determines prevailing pro‐inflammatory vs anti‐inflammatory responses in untrained and trained participants, respectively, highlighting a likely cause‐effect relationship between degree of physical activity and P2X7R‐Infl‐mediated responses.
Vascular risk factors and depression in Parkinson's disease
Authors: Ou R. , Wei Q. , Hou Y. , Yuan X. , Song W. , Cao B. , Liu H. , Zhang L. , Chen Y. , Shang H. 
Published: December 2017

Background and purposeThe aim of this study was to address the vascular depression hypothesis in Parkinson's disease (PD) from a large cohort of Chinese population.MethodsA cross‐sectional analysis of 1784 Chinese patients with PD was conducted. Patients were divided into absence of depression (score ≤ 20) and presence of depression (score > 20) based on assessment of the Hamilton Depression Rating Scale. Other clinical assessments included the Unified PD Rating Scale (UPDRS), the Hamilton Anxiety Rating Scale, the frontal assessment battery (FAB) and the Montreal Cognitive Assessment (MoCA).ResultsPatients with depression showed a higher proportion of women, longer disease duration, higher UPDRS part III score, higher levodopa equivalent daily dose use, higher occurrences of motor fluctuation and dyskinesia, lower FAB score and lower MoCA score than those without depression (P < 0.05). The proportions of drinking and overweight/obesity in the depression group were significantly lower than those in the non‐depression group (P < 0.05). A forward binary logistic regression model indicated that depression in PD was associated with female sex [odds ratio (OR) 1.376, P = 0.025], higher UPDRS part III score (OR 1.042, P < 0.001), lower FAB score (OR 0.937, P = 0.015), anxiety (OR 18.156, P < 0.001) and overweight/obesity (OR 0.700, P = 0.019), whereas no associations were found with hypertension, diabetes, smoking, drinking, hyperlipidaemia and heart disease.ConclusionsOur study failed to verify the vascular depression hypothesis in PD. On the contrary, it was demonstrated that overweight/obesity is negatively associated with the presence of depression in PD.