bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Reorganization across Four Episodes in Bipolar Disorder
Authors: Liu Xiaobo , Wan Bin , Zhang Xi-Han , Cui Ruifang , Long Siyu , Ge Ruiyang , Liu Lang , Xiao Jinming , Liu Zhen-Qi , Yan Jiadong , Xie Ke , Yao Meng , Wen Xin , Wang Sanwang , Gao Yujun 
Published: September 2024

AbstractBipolar disorder (BD) is a heterogeneous psychiatric condition encompassing various episode states, including manic (BipM), depressive (BipD), mixed (mBD), and remission (rBD). Cumulative evidence has revealed that few BD episodes exhibit brain functional connectome changes; however, these findings remain fragmentary, and a systematic understanding of these functional alterations among all episodes is still lacking. Here, we firstly aimed to investigate how these episodes are differentially represented along the sensory-association axis, which constitutes the primary functional organization spectrum of the human cortex. We found expansion in sensory regions with compression in association regions in BipM, BipD and rBD as well as expansion in visual regions and prefrontal regions, compression motor regions, and precuneus regions for mBD compared to healthy controls. By examining outward and inward activity propagation in association regions, we observed less frequent flows in BipM and BipD, clarifying that association may be dominant in functional reorganization. mBD showed more frequent inward flows than other episodes in both sensory and associations, emphasizing information exchange between these two anchors. By evaluating the network integration and segregation, we observed an increase in functional integration alongside a decrease in functional segregation for unipolar episodes and the greatest functional integration for mBD. Furthermore, clinical relevance analysis suggests that emotional changes were mainly related to association functional reorganization, which may be used as specific and sensitive biomarkers to detect mood changes in different episodes. Finally, the episode representations were spatially correlated with distribution of serotonin transporter, gamma-aminobutyric acid type A receptor, Alpha-4-Beta-4 nicotinic acetylcholine receptor, layer 4 and layer 5 excitatory neurons. This study demonstrates functional reorganization as a biomarker as well as a uniform and simplified framework of neural phenotype to quantify mental abnormality of different BD episodes systematically.
Predictors of white matter hyperintensities in the elderly Congolese population
Authors: Yohe Emile Omba , Alonso Alvaro , Drane Daniel L. , Patel Saranya Sundaram , Schwinne Megan , Epenge Emmanuel , Gikelekele Guy , Herve Esambo , Kavugho Immaculee , Tshengele Nathan , Mampunza Samuel , Mananga Lelo , Zhao Liping , Qiu Deqiang , Stringer Anthony , Saindane Amit M , Ikanga Jean 
Published: September 2024

ABSTRACTBackgroundWhite matter hyperintensities (WMHs) are strongly linked to cardiovascular risk factors and other health conditions such as Alzheimer’s disease. However, there is a dearth of research on this topic in low-income countries and underserved populations, especially in the Democratic Republic of Congo (DRC) where the population is aging rapidly with increasing cardiovascular risk factors and dementia-related diseases. This study evaluates health factors associated with WMH in the elderly Sub-Saharan Africa (SSA), specifically Congolese adults.MethodsIn a cross-sectional study of 77 people from the DRC, participants underwent neuroimaging to analyze WMH volume and completed clinical evaluation, laboratory-based blood exams, self-reported questionnaires, and interviews. A simple linear regression model was conducted to test the association between WMH and potential predictors (neurological status, age, sex, hypertension, diabetes, tobacco abuse, stroke, high cholesterol, cardiovascular medication, and alcohol abuse). Stepwise selection and backward elimination analyses were performed to obtain the final model. Finally, a multiple linear regression model was conducted to assess the association between WMH and variables retained in the final model (neurological status, sex, and age).ResultsOf the 77 individuals, 47 (61%) had dementia, 40 (52.6%) were males, and the mean age was 73 years (± 8.0 years standard deviation). In simple linear regression models, WMH was significantly associated with dementia (expβ1=1.75, 95% CI=1.14 – 2.71, p-value=0.01) though it had a weak association with age (expβ1=1.03, 95% CI=1.00 – 1.05, p-value=0.05) and sex (male) (expβ1=0.66, 95% CI=0.43 – 1.01, p-value=0.05). In multiple linear regression models, WMH was statistically significantly associated with dementia (expβ1=1.97, 95% CI=1.31 – 2.95, p-value =0.001), male sex (expβ2=0.54, 95% CI=0.36 – 0.80, p-value=0.003), and age (expβ3=1.03, 95% CI=1.00 – 1.06, p-value=0.03). However, WMH was not significantly associated with common cardiovascular risk factors, such as high blood pressure, diabetes, tobacco use, obesity, and high cholesterol levels.ConclusionWMH is significantly associated with neurological status, sex, and age in the Congolese population. Understanding these predictors may improve our ability to diagnose, assess, and develop preventative treatments for white matter disease in SSA/DRC populations, where neuroimaging is difficult to obtain.
Gut microbiome compositional and functional features associate with Alzheimer’s disease pathology
Authors: Kang Jea Woo , Khatib Lora A. , Heston Margo B. , Dilmore Amanda H. , Labus Jennifer S. , Deming Yuetiva , Schimmel Leyla , Blach Colette , McDonald Daniel , Gonzalez Antonio , Bryant MacKenzie , Sanders Karenina , Schwartz Lara , Ulland Tyler K. , Johnson Sterling C. , Asthana Sanjay , Carlsson Cynthia M. , Chin Nathaniel A. , Blennow Kaj , Zetterberg Henrik , Rey Federico E. ,   Alzheimer Gut Microbiome Project Consortium, Kaddurah-Daouk Rima , Knight Rob , Bendlin Barbara B. 
Published: September 2024

AbstractBACKGROUNDThe gut microbiome is a potentially modifiable factor in Alzheimer’s disease (AD); however, understanding of its composition and function regarding AD pathology is limited.METHODSShallow-shotgun metagenomic data was used to analyze fecal microbiome from participants enrolled in the Wisconsin Microbiome in Alzheimer’s Risk Study, leveraging clinical data and cerebrospinal fluid (CSF) biomarkers. Differential abundance and ordinary least squares regression analyses were performed to find differentially abundant gut microbiome features and their associations with CSF biomarkers of AD and related pathologies.RESULTSGut microbiome composition and function differed between people with AD and cognitively unimpaired individuals. The compositional difference was replicated in an independent cohort. Differentially abundant gut microbiome features were associated with CSF biomarkers of AD and related pathologies.DISCUSSIONThese findings enhance our understanding of alterations in gut microbial composition and function in AD, and suggest that gut microbes and their pathways are linked to AD pathology.
The Impact of Estrogen-Suppressing Contraceptives on Behavioral and Functional Difficulties in Borderline Personality Disorder
Authors: Katrinli Seyma , Rothbaum Alex O. , DeMoss Raneeka , Turner William C. , Hunter Ben , Powers Abigail , Michopoulos Vasiliki , Smith Alicia K. 
Published: September 2024

AbstractBorderline Personality Disorder (BPD) is characterized by rapidly shifting emotional, interpersonal, and behavioral symptoms, and is often co-morbid with mood and anxiety disorders. Females are more likely to be diagnosed with BPD than males and exhibit greater functional impairment. Hormonal fluctuations, particularly in estrogen levels, may influence the manifestation of BPD symptoms. Here we investigated the influence of estrogen-suppressing contraceptives on behavioral and functional difficulties in BPD. The analytical sample included 348 females ages 18-50 undergoing residential treatment for psychiatric disorders, with 131 having a BPD diagnosis. Patients were categorized based on their contraceptive method: 1) Estrogen-suppressing contraceptives (N=145) and 2) Naturally cycling (N=203). Interaction models tested the impact of estrogen-suppressing contraceptives on the relationship between BPD diagnosis and behavioral and functional difficulties at admission and discharge, assessed by the four Behavior and Symptom Identification Scale (BASIS-32) domains: difficulties in relationships, daily living, depression/anxiety, and impulsivity. Females with a BPD diagnosis were more likely to use estrogen-suppressing contraceptives compared to those without BPD (p=0.04). However, estrogen-suppressing contraceptive use was not associated with behavioral and functional difficulties at admission, discharge, or over time. Estrogen-suppressing contraceptives moderated the association between BPD diagnosis and difficulties in relationships (p=0.004), difficulties in daily living (p=0.01), and depression/anxiety symptoms (p=0.004). Patients with BPD expressed increased behavioral and functional difficulties at admission, discharge, and over time only if naturally cycling (p<0.003). Our findings suggest that estrogen-suppressing contraceptives may help to regulate the rapidly shifting emotional, interpersonal, and behavioral symptoms in females with BPD by stabilizing estrogen levels.
Brief remote psychological treatments for healthcare workers with emotional distress during the SARS-CoV-2 pandemic: a randomized clinical trial
Authors: Salum Giovanni Abrahão , de Abreu Costa Marianna , Spanemberg Lucas , Simioni André Rafael , Gosmann Natan Pereira , de Souza Lívia Hartmann , Cuijpers Pim , Pine Daniel Samuel , Brunoni André Russowsky , Kristensen Christian Haag , de Almeida Fleck Marcelo Pio , Manfro Gisele Gus , Dreher Carolina Blaya 
Published: September 2024

SUMMARYBACKGROUNDThe SARS-CoV-2 pandemic has catalyzed a widespread mental health crisis, impacting millions of people. This study aimed to compare three brief remote psychological treatments for healthcare workers with emotional distress during the SARS-CoV-2 pandemic.METHODSNationwide three-arm randomized clinical trial in Brazil. This is a transdiagnostic study that included professionals and students from health services with high levels of anxiety, depression, or irritability symptoms, as defined by Patient-Reported Outcomes Measurement Information System (PROMIS). The exclusion criterion was positive suicide risk. Participants were randomized single session psychoeducation group plus weekly personalized pre-recorded videos for four weeks (SSI-ET), brief cognitive behavioral telepsychotherapy group (B-CBT, four sessions), or brief interpersonal telepsychotherapy (B-IPT, four sessions). This study was registered inclinicaltrials.gov(NCT04635618). The primary outcome was the proportion of participants with a 50% reduction in T-scores in PROMIS rating scales of anxiety, depression, and/or irritability at one-month.FINDINGSOf the 3328 volunteers assessed for eligibility, 999 participants were enrolled, from May 19th2020 to December 31st2021, and allocated to SSI-ET (n=342), B-CBT (n=323), or B-IPT (n=334). All three groups showed significant symptom reductions in the one-month assessment that were maintained over the three and six-month follow-ups (Cohen’s d range = 0.94-1.36, p<0.001), with no significant difference between groups. The estimated proportion of responders were 46.5%, 43.7% and 44.6% for SSI-ET, B-CBT and B-IPT, respectively.ConclusionsOur results refute the hypothesis that therapeutic interventions with higher number of sessions and with more specialized therapeutic components offer advantages in alleviating emotional distress, particularly among healthcare workers facing epidemic emergencies. These results have critical implications for planning interventions for crisis responses, especially in settings with limited resources.FUNDINGMinistry of Health of Brazil, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, and Fundo de Incentivo à Pesquisa/Hospital de Clínicas de Porto Alegre.
Spatiotemporal dynamics of locomotor decisions inDrosophila melanogaster
Authors: Lebovich Lior , Alisch Tom , Redhead Edward S. , Parker Matthew O. , Loewenstein Yonatan , Couzin Iain D. , de Bivort Benjamin L. 
Published: September 2024

AbstractDecision-making in animals often involves choosing actions while navigating the environment, a process markedly different from static decision paradigms commonly studied in laboratory settings. Even in decision-making assays in which animals can freely locomote, decision outcomes are often interpreted as happening at single points in space and single moments in time, a simplification that potentially glosses over important spatiotemporal dynamics. We investigated locomotor decision-making inDrosophila melanogasterin Y-shaped mazes, measuring the extent to which their future choices could be predicted through space and time. We demonstrate that turn-decisions can be reliably predicted from flies’ locomotor dynamics, with distinct predictability phases emerging as flies progress through maze regions. We show that these predictability dynamics are not merely the result of maze geometry or wall-following tendencies, but instead reflect the capacity of flies to move in ways that depend on sustained locomotor signatures, suggesting an active, working memory-like process. Additionally, we demonstrate that fly mutants known to have sensory and information-processing deficits exhibit altered spatial predictability patterns, highlighting the role of visual, mechanosensory, and dopaminergic signaling in locomotor decision-making. Finally, highlighting the broad applicability of our analyses, we generalize our findings to other species and tasks. We show that human participants in a virtual Y-maze exhibited similar decision predictability dynamics as flies. This study advances our understanding of decision-making processes, emphasizing the importance of spatial and temporal dynamics of locomotor behavior in the lead-up to discrete choice outcomes.
Roles of value co-creation on social platforms in driving participating businesses’ sustainable competitive advantage and performance
Authors: Liu Honglei , Choi Chang Suk , Kim Kyung Hoon 
Published: September 2024

PurposeThis study discusses the sources of value co-creation and its effects on businesses using social platforms such as Facebook, Instagram, Twitter and blogs.Design/methodology/approachA total of 301 survey responses were selected. The selected respondents indicated that they lived in South Korea, had an occupation as a private business or marketer and had used a social platform one or more times a day. The hypotheses were tested using a structural equation model.FindingsThe study reveals that the source of sustainable value co-creation between social platforms and businesses positively affects the competitive advantage of maintaining businesses. This advantage reveals an integrated relationship that leads to the successful financial performance of businesses through online word of mouth and customer satisfaction. Moreover, this study finds that the relationship between variables differs by social platform types (unidirectional vs bidirectional service).Research limitations/implicationsThe results of this study explain the relationship between value co-production, value-in-use, SCA and long-term performance. However, this study focused on private business and marketing staff working in companies in South Korea. Accordingly, more countries in which social platforms are widely utilized should be taken into account to help generalize the empirical findings.Practical implicationsThere is a difference in the relationship between co-creation activity and cost advantage/long-term performance in accordance with the service type of a social platform. The results indicate that a bidirectional service is a more powerful tool for cost advantage and long-term performance.Originality/valueThis study focuses on the role of value co-creation in social platforms to ensure companies’ sustainable competitive advantage and performance. The results of this study will help companies develop online marketing strategies using social platforms.
Experienscape and psychology in silver screen destinations: exploring the effects of cognition and affect
Authors: Radic Aleksandar , Quan Wei , Ariza-Montes Antonio , Han Heesup 
Published: September 2024

Purpose
This study aims to evaluate the behavioral predictors that affect tourists’ intentions to visit silver screen destinations.

Design/methodology/approach
The survey questionnaire was composed of multi-item measures, and a total of 432 questionnaires were collected by purposive sampling technique. Participants were asked about sensory stimuli, social stimuli, naturalistic stimuli, cultural stimuli, hospitality culture stimuli, cognitive responses, affective responses and behavior approach, which were evaluated using a seven-point Likert scale.

Findings
The authors discovered that cognitive and affective responses positively influence the tourists’ intention toward destinations with film-induced tourism, because tourists highly value unique and refreshing symbolic connotations of silver screen destinations, which are commonly predisposed to nostalgia and poetic on the scene.

Originality/value
The originality of this study and the theoretical value of the present research lies with revealing specific relations within the film-induced experienscape constructs that are based on the multistakeholder and multidisciplinary approach. Moreover, this study puts forward constructive suggestions for destination stakeholders in regard to how to market film-induced tourism that uses a multidisciplinary approach that is encompassed by experienscape constructs, which thereby reinforces the film-induced tourists’ experience and their behavior approach.
Ethics in focus: PhD students’ perspectives on IRBs in India
Authors: A Subaveerapandiyan , Taj Amreen , Ahmad Naved , Verma Manoj Kumar , Ahmed Mohammed Gulzar 
Published: September 2024

Purpose
This study aims to explore the knowledge, attitudes, and experiences of PhD students in India regarding research ethics and institutional review boards (IRBs), assess awareness levels, identify training gaps, examine ethical priorities and understand challenges in the IRB application process.

Design/methodology/approach
A quantitative approach was used, and a self-evaluator questionnaire was distributed electronically to PhD students. Data collection occurred between 1 March 1 and 30 March 2024, with analysis conducted using SPSS software.

Findings
The study reveals a significant gap in formal training on IRB procedures within PhD programs and challenges in completing IRB applications despite recognising ethical priorities such as informed consent and confidentiality.

Originality/value
This study provides insights into PhD students’ perspectives on research ethics and IRBs in India, highlighting the need for enhanced education and awareness initiatives to promote responsible conduct and safeguard research participants.
Examining the role of bullying victimization in predicting psychopathology among in-school Nigerian adolescents
Authors: Awhangansi Sewanu , Salisu Titilayo , Awhangansi Oluwayemisi , Dadematthews Adefunke , Abumere Eghonghon , Siddiq Benazir , Phillips Eden , Mogan Meera , Olushola Ayoyimika , Archibong Atim , Okewole Adeniran , Adeosun Increase , Sowunmi Oladipo , Amosu Sunday , Lewis Michael , Archard Philip John , Owoeye Olugbenga , O'Reilly Michelle 
Published: September 2024

Purpose
This paper aims to examine the role of bullying victimization in predicting psychopathology, encompassing post-traumatic stress disorder (PTSD), risk of developing prodromal psychosis and emotional and behavioural problems, among in-school Nigerian adolescents.

Design/methodology/approach
A total of 351 junior secondary students (n = 173 males, 178 females; age range: 9–17 years) were recruited from five randomly selected public secondary schools in Nigeria. Students completed a variety of self-report measures, including a socio-demographic questionnaire, the prodromal questionnaire – brief version, the strengths and difficulties questionnaire (SDQ) and the multidimensional peer victimization scale. They were also interviewed using the PTSD module of the Mini International Neuropsychiatric Interview-Kid Version.

Findings
Although bullying victimization was not found to predict the presence of PTSD, it predicted the risk of developing prodromal psychosis. All SDQ subscales also held significant positive associations with bullying victimization. This indicates that higher levels of victimization are associated with increased behavioural and emotional difficulties among adolescents.

Practical implications
The study findings add support to whole system approaches involving relevant stakeholders in health, education, social and criminal justice sectors via protective policies to address the problems of bullying in schools.

Originality/value
The study contributes to evidence demonstrating a need for improved understanding regarding the role of exposure to bullying victimization in predicting various forms of psychopathology. Furthermore, there is specifically a need for research with this focus in developing countries in sub-Saharan Africa and the Nigerian education system.
Cost-utility evaluation of a health and social care integration programme for frail older adults in Argentina
Authors: Perman Gaston , Prevettoni Mariana , Guenzelovich Tami , Schapira Marcelo , Saimovici Javier , González María Victoria , Ramos Roxana , Garfi Leonardo , Hornstein Lucila , Gallo Acosta Cristian , Cunha Ferré María Florencia , Scozzafava Silvana , Vassallo Sella Carlos 
Published: September 2024

PurposeOur objective was to evaluate the cost-utility of a health and social care integration programme for frail older adults in Buenos Aires, Argentina.Design/methodology/approachBased on a study of the programme’s effectiveness, a Markov model was conducted to assess its cost-utility. The active intervention was the health and social care integration programme, and the control was the best standard of care so far. The setting was the patients' home of residence. A third-party payer perspective and a lifelong time horizon were adopted. All transition probabilities, quality-adjusted life years (QALYs) and costs were estimated from the effectiveness study. A discount rate of 3.5% was applied to costs and benefits. Costs are expressed in international dollars (Int$), calculated according to the International Monetary Fund’s purchasing power parity rate. Different sensitivity analyses were performed. The model was built in Excel 365. Construct validity, verification during model construction and internal consistency of the results were assessed.FindingsThe programme had an average cost of Int$18,768.22/QALY, and the control Int$42,609.68/QALY. In the incremental analysis, the programme saved Int$26,436.10 and gained 0.81 QALYs over the control. In the sensitivity analyses, in 99.96% of cases, the programme was less costly and more effective.Practical implicationsThe cost savings can facilitate the scalability.Originality/valueThe health and social care integration programme for frail older adults was more effective and less costly than the best standard of care to date. This study contributes to the scarce evidence on the efficiency of integrated care strategies for frail older persons.