bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis
Authors: Murphy Susan L. , Kratz Anna L. , Kidwell Kelley , Lyden Angela K. , Geisser Michael E. , Williams David A. 
Published: March 2016

Abstract
Osteoarthritis (OA) of the lower extremities is a prevalent cause of disability in which symptoms interfere with mobility and activity participation. Behavioral self-management for OA symptomatology is commonly recommended; but these interventions are underutilized, unstandardized in application, and at times, unavailable in the context of clinical care. For people with chronic pain, rehabilitation professionals may select to apply activity pacing instruction as one behavioral strategy to manage symptoms. Activity pacing is widely used in combination with other pharmacological and behavioral interventions but has not been studied as a singular behavioral intervention for people with OA. The purpose of this study was to evaluate the effectiveness of an occupational therapist-delivered, time-based activity pacing program for treatment of pain, fatigue, and physical function in people with symptomatic knee or hip OA. A 3-arm randomized controlled trial was conducted in which 193 people were randomized into tailored activity pacing, general activity pacing, or usual care arms. Assessments were done at 10 weeks and 6 months after baseline. Using linear mixed models, Western Ontario and McMaster Universities Osteoarthritis Index pain scores changed over time, decreasing the most in the general and usual care groups; only the usual care group had decreased pain over 6 months. The tailored and general activity pacing groups reported higher frequency of pacing behaviors than the usual care group at 10 weeks, but pacing was not sustained at 6 months. This trial does not support the use of time-based pacing as a singular behavioral strategy for people with knee or hip OA.
Free Amino Acids in Human Milk and Associations With Maternal Anthropometry and Infant Growth
Authors: Larnkjær Anni , Bruun Signe , Pedersen Dorthe , Zachariassen Gitte , Barkholt Vibeke , Agostoni Carlo , M⊘lgaard Christian , Husby Steffen , Michaelsen Kim F. 
Published: March 2016

ABSTRACTObjectives:Free glutamic acid has an appetite‐regulating effect and studies with infant formula have suggested that free amino acids (FAA), especially glutamic acid, can downregulate intake. The content of glutamic acid and glutamine is high in breast milk but varies considerably between mothers. The aim was to investigate whether maternal anthropometry was associated with the content of the FAA glutamic acid or glutamine in breast milk and whether there was a negative association between these FAA and current size or early infant growth in fully breastfed infants.Methods:From a subgroup of 78 mothers, of which 50 were fully breast feeding, from the Odense Child Cohort breast milk samples were collected 4 months after birth and analyzed for FAA. Information regarding breastfeeding status and infant weight and length was also recorded.Results:There was a large variation in the concentration of the FAAs between mothers. Glutamic acid was positively correlated with mother's prepregnancy weight and height (P ⩽ 0.028), but not body mass index. There was no negative correlation between the 2 FAA and infant weight or body mass index. Infant length at 4 months was, however, positively associated with glutamine, (P = 0.013) but the correlation was attenuated when controlling for birth length (P = 0.089).Conclusions:The hypothesis that a high content of glutamic acid and glutamine in breast milk could downregulate milk intake to a degree affecting early growth could not be confirmed. Maternal factors associated with the level of these FAA in milk and the potential effect on the infant should be investigated further.
A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data
Authors: Bjelland Douglas W. , Lingala Uday , Patel Piyush S. , Jones Matt , Keller Matthew C. 
Published: March 2016

AbstractIdentical by descent (IBD) segments are used to understand a number of fundamental issues in genetics. IBD segments are typically detected using long stretches of identical alleles between haplotypes in whole-genome SNP data. Phase or SNP call errors in genomic data can degrade accuracy of IBD detection and lead to false positive calls, false negative calls, and under‐ or overextension of true IBD segments. Furthermore, the number of comparisons increases quadratically with sample size, requiring high computational efficiency. We developed a new IBD segment detection program, FISHR (FindIBDSharedHaplotypesRapidly), in an attempt to accurately detect IBD segments and to better estimate their endpoints using an algorithm that is fast enough to be deployed on the very large whole-genome SNP datasets. We compared the performance of FISHR to three leading IBD segment detection programs: GERMLINE, refinedIBD, and HaploScore. Using simulated and real genomic sequence data, we show that FISHR is slightly more accurate than all programs at detecting long (>3 cM) IBD segments but slightly less accurate than refinedIBD at detecting short (~1 cM) IBD segments. Moreover, FISHR outperforms all programs in determining the true endpoints of IBD segments, which is important for several reasons. FISHR takes two to four times longer than GERMLINE to run, whereas both GERMLINE and FISHR were orders of magnitude faster than refinedIBD and HaploScore. Overall, FISHR provides accurate IBD detection in unrelated individuals and is computationally efficient enough to be utilized on large SNP datasets > 20,000 individuals.
Active Microrheology of Intestinal Mucus in the Larval Zebrafish
Authors: Taormina Michael J. , Parthasarathy Raghuveer 
Published: March 2016

AbstractMucus is a complex biological fluid that plays a variety of functional roles in many physiological systems. Intestinal mucus in particular serves as a physical barrier to pathogens, a medium for the diffusion of nutrients and metabolites, and an environmental home for colonizing microbes. Its rheological properties have therefore been the subject of many investigations, thus far limited, however, toin vitrostudies due to the difficulty of measurement in the natural context of the gut. This limitation especially hinders our understanding of how the gut microbiota interact with the intestinal environment, since examination of this calls not only for in vivo measurement techniques, but for techniques that can be applied to model organisms in which the microbial state of the gut can be controlled. We address this challenge by developing a method that combines magnetic microrheology, light sheet fluorescence microscopy, and microgavage of particles, applying this to the larval zebrafish, a model vertebrate. We present measurements of the viscosity of mucus within the intestinal bulb of both germ-free (devoid of intestinal microbes) and conventionally reared larval zebrafish. At the length scale probed (≈ 10μm), we find that mucus behaves as a Newtonian fluid, with no discernable elastic component. Surprisingly, despite known differences in the the number of secretory cells in germ-free zebrafish and their conventional counterparts, the fluid viscosity for these two groups was very similar. Our measurements provide the firstin vivomeasurements of intestinal mucus rheology at micron length scales in living animals, quantifying of an important biomaterial environment and highlighting the utility of active magnetic microrheology for biophysical studies.
Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)
Authors: Hill W David , Hagenaars Saskia P , Marioni Riccardo E , Harris Sarah E , Liewald David CM , Davies Gail ,   International Consortium for Blood Pressure, McIntosh Andrew M , Gale Catharine R , Deary Ian J 
Published: March 2016

SummaryIndividuals with lower socio-economic status (SES) are at increased risk of physical and mental illnesses and tend to die at an earlier age [1-3]. Explanations for the association between SES and health typically focus on factors that are environmental in origin [4]. However, common single nucleotide polymorphisms (SNPs) have been found collectively to explain around 18% (SE = 5%) of the phenotypic variance of an area-based social deprivation measure of SES [5]. Molecular genetic studies have also shown that physical and psychiatric diseases are at least partly heritable [6]. It is possible, therefore, that phenotypic associations between SES and health arise partly due to a shared genetic etiology. We conducted a genome-wide association study (GWAS) on social deprivation and on household income using the 112,151 participants of UK Biobank. We find that common SNPs explain 21% (SE = 0.5%) of the variation in social deprivation and 11% (SE = 0.7%) in household income. Two independent SNPs attained genome-wide significance for household income, rs187848990 on chromosome 2, and rs8100891 on chromosome 19. Genes in the regions of these SNPs have been associated with intellectual disabilities, schizophrenia, and synaptic plasticity. Extensive genetic correlations were found between both measures of socioeconomic status and illnesses, anthropometric variables, psychiatric disorders, and cognitive ability. These findings show that some SNPs associated with SES are involved in the brain and central nervous system. The genetic associations with SES are probably mediated via other partly-heritable variables, including cognitive ability, education, personality, and health.
Novel Genetic Risk factors for Asthma in African American Children: Precision Medicine and The SAGE II Study
Authors: White MJ , Risse-Adams O , Goddard P , Contreras MG , Adams J , Hu D , Eng C , Oh SS , Davis A , Meade K , Brigino-Buenaventura E , Lenoir MA , Bibbins-Domingo K , Pino-Yanes M , Burchard E 
Published: March 2016

AbstractBackgroundAsthma, an inflammatory disorder of the airways, is the most common chronic disease of children worldwide. There are significant racial/ethnic disparities in asthma prevalence, morbidity and mortality among U.S. children. This trend is mirrored in obesity, which may share genetic and environmental risk factors with asthma. The majority of asthma biomedical research has been performed in populations of European decent.ObjectiveWe sought to identify genetic risk factors for asthma in African American children. We also assessed the generalizability of genetic variants associated with asthma in European and Asian populations to African American children.MethodsOur study population consisted of 1227 (812 asthma cases, 415 controls) African American children with genome-wide single nucleotide polymorphism (SNP) data. Logistic regression was used to identify associations between SNP genotype and asthma status.ResultsWe identified a novel variant in thePTCHD3gene that is significantly associated with asthma (rs660498, p = 2.2 x10−7) independent of obesity status. Approximately 5% of previously reported asthma genetic associations identified in European populations replicated in African Americans.ConclusionsOur identification of novel variants associated with asthma in African American children, coupled with our inability to replicate the majority of findings reported in European Americans, underscores the necessity for including diverse populations in biomedical studies of asthma.
Network-based innovation: the case for mobile gaming and digital music
Authors: Castro Soeiro Filipe , Santos Mariana , Alves José 
Published: March 2016

Purpose
This paper aims to identify, analyze and discuss a potential new business opportunity that arises from the intersection of the digital music and game industries across borders throughout network-based innovation approach.

Design/methodology/approach
The research draws on review of industry and academic literature, two online surveys and interviews, overall encompassed by a interpretative exploratory research methodology strategy.

Findings
The study supports the interest and potential for developing new products that combine digital music and casual digital games and that draw on firms from more than one region, while potentially involving a wide set of social network key stakeholders.

Research limitations/implications
This is an exploratory study in which findings should be challenged by confirmatory studies, including new product design and development of modeling techniques and network-based innovation approaches. This research contributes for the generation of new insights over technological and social driving forces, as well as emerging trends that shed light on the global competitiveness and on convergence of mobile gaming and digital music industries at regional innovation systems view. It also discusses spillover mechanisms based on new knowledge creation, knowledge diffusion and knowledge appropriation throughout the key stakeholders. The customer-centric innovation and network value autocorrelation hypothesis was validated, and both technology convergence and social factors are enhancement factors for innovation. Limitations and further research with larger sampling, specialization techniques and empirical modeling to in-depth analysis is suggested.

Practical implications
The study provides a framework for managers to develop new products that merges boundaries of related industries and encourages network-based innovation and cooperation between industry players, involving different regions. Ultimately, it shows opportunities of diversification, by introducing new products into new markets, as result of interdependence, soft factors, knowledge spillover and absorptive capacity mechanisms over a network of key stakeholders across different regions throughout customer-centric innovation, while impacting also new discussion on entrepreneurship and knowledge spillover theory and policy making.

Social implications
Social capital network is key for innovation and knowledge spillover among industry players. Content creation regarding products and services show high dependence on spatial external cultural influences, tastes and habits for customer-centric innovation, while impacting on social and learning customer experience, as well.

Originality/value
The paper has value for product development and innovation managers, researchers and practitioners. It discusses the value of innovation systems that are purposively developed beyond traditional geographic and industry boundaries.
School autonomy, leadership and learning: a reconceptualisation
Authors: Cheng Yin Cheong , Ko James , Lee Theodore Tai Hoi 
Published: March 2016

Purpose– The purpose of this paper is to develop a framework for reconceptualising research on school autonomy to redress the limitations of traditional research, strengthen the conceptual links between school autonomy and learning outcomes and offer a range of new strategies for studying the interplay of school autonomy, leadership and learning.Design/methodology/approach– Based on a review of international studies and the findings of the Programme for International Student Assessment (PISA) and the Teaching and Learning International Study (TALIS), the conceptual limitations of and gaps in traditional research on school autonomy in relation to leadership and learning are discussed, and their implications for the development of a new framework are outlined.Findings– The conceptual limitations of traditional research on school autonomy are as follows: internal school autonomy is insufficiently differentiated; too little attention is paid to cultural autonomy and internal structural autonomy at individual and group levels; autonomy is measured only as perceived by principals, with no attention to the perspectives of other key stakeholders; and conceptual links between school autonomy and learning outcomes are missing, leading to inconsistent findings on the effects of school autonomy on student learning. To redress these limitations, a new framework for research is developed. School autonomy is reconceptualised as a combination of functional autonomy, structural autonomy and cultural autonomy. Leadership is also reconceptualised by categorising three types of leadership activity: leadership for functional initiatives, leadership for structural initiatives and leadership for cultural initiatives. This categorisation may help to strengthen conceptions of the relevance of leadership to autonomy and performance in future research.Research limitations/implications– A typology of research strategies is developed to broaden the possibilities for implementing the reconceptualisation framework. A single-component strategy, a two-component strategy, an interaction strategy and a holistic case-study strategy are presented. Depending on the research purposes and the available resources, one or a combination of these strategies can be used to conceptualise the study of school autonomy, leadership and performance.Originality/value– The new ideas and perspectives associated with the reconceptualisation framework will contribute to future research in this area on an international scale. Future PISA, TALIS and similar studies will also benefit from this reconceptualisation.
When workfare fails: post-crisis activation reform in the Czech Republic
Authors: Sirovatka Tomas 
Published: March 2016

Purpose– The purpose of this paper is to analyse Czech’s activation reforms enacted since 2006 which culminated in 2010-2012 as radical workfare-like reforms. It also aims to explain which factors have influenced their development.Design/methodology/approach– The paper is the case study of activation reforms in one country interpreted within the theoretical framework of the “activation models” and discussion of the factors influencing activation reforms. The design and implementation of the reforms of activation policies are in focus. Institutional analysis is combined with secondary statistical data and survey data.Findings– The author distinguish three phases of the activation reforms: the initial phase of activation (work first), the radical phase (workfare) and the failure of radical workfare as the final phase. The key argument is that the main factors leading to the radical workfare version of activation were the political factors combined with institutional factors, particularly, the specific model of policy making (the so-called “compost model”). Ironically, this model which has enabled fast and radical workfare-like reforms was also the main reason why the reforms failed.Originality/value– The paper is innovative since it explains the specific features of the activation reforms in the Czech Republic, distinguishing workfare from other models of activation, and identifying the factors which have played a role in shaping these features. The in-depth case study of one country provides the evidence on the role of the specific factors and helps the author to understand the motives, the design and the implementation of activation reforms in their mutual relationships. The specific role of the institutional legacy in the new circumstances is emphasized.
A study of academic performance by immigrant generation with an emphasis on the black immigrant experience
Authors: Obinna Denise N 
Published: March 2016

Purpose– Instead of identifying them as a single monolithic group, the purpose of this paper is to evaluate whether the academic performance of black immigrants differs from African Americans as well as Asian and Hispanic students of comparable immigrant generation. By identifying how well black immigrant students perform on standardized tests, grade point averages (GPA) and college enrollment, this study proposes a more comprehensive look into this growing immigrant group.Design/methodology/approach– The research uses a data from the Educational Longitudinal Survey of high school sophomores conducted by the National Center for Education Statistics. Data used in this study are from the baseline survey in 2002 and the second follow-up in 2006 when most students had graduated from high school. The methodology includes OLS, binary and ordered logistic regression models.Findings– The study finds that while second-generation blacks outperform the native-born generation on standardized tests, this does not extend to GPA or college enrollment. In fact, it appears that only second-generation Hispanic students have an advantage over their native-born counterparts on GPA and standardized tests. Furthermore, first and second-generation Asian immigrants do not show a higher likelihood of enrolling in college than their native-born counterparts nor do they report higher GPA.Originality/value– This paper sheds light on a growing yet understudied immigrant population as well as drawing comparisons to other immigrant groups of comparable generation.
An exemplar of GP commissioning and child and adolescent mental health service partnership
Authors: Humphrey Ayla , Eastwood Lynne , Atkins Helen , Vainre Maris , Lea-Cox Caroline 
Published: March 2016

Purpose
– The purpose of this paper is to draw attention to commissioning and service structures enabling implementation of evidence-based cost-effective care as illustrated by the “1419” young people’s service treating mild to moderate severity mental health difficulties in teenagers old 14 to 19 years. The authors describe relevant local contextual factors: “relational commissioning”, demand capacity planning and a receptive and safe clinical context.

Design/methodology/approach
– The authors used a participant observer qualitative research design to describe commissioning and service design. Treatment outcomes were analysed using a quantitative design and found significant improvement in service user mental health and daily function. These results will be reported elsewhere.

Findings
– The dynamics and structures described here enabled clear shared goals between service user, service purchaser, service provider and service partners. The goals and design of the service were not static and were subject to ongoing development using routine outcome measures and conversations between referrers, commissioners, service users and within the team about what was and was not working.

Research limitations/implications
– The methods are limited by the lack of a prospective systematic evaluation of the implementation process and by the time limitations of the service.

Practical implications
– Implementation of whole system change such as that envisioned by Children and Young People’s Improving Access to Psychological Therapies requires consideration of local context and process of implementation. The authors suggest key factors: consideration of “relational commissioning” with purchasers, providers and service users designing services together; case-level collaboration between services and partner agencies; smaller child and adolescent mental health teams eliminating competing task demands, permitting speed of action, providing psychological safety for staff, promoting shared goals and innovation; rigorous demand/capacity planning to inform funding.

Social implications
– The failings of child and adolescent mental health services (CAMHS) are detailed in the Department of Health report “Future in mind: promoting, protecting and improving our children and young people’s mental health and wellbeing” (2015). The aims of the report are contingent on the ability of local health providers to implement its recommendations. The authors provide a theoretical approach to enable this implementation.

Originality/value
– To date there are no published papers addressing the key characteristics enabling implementation of evidence-based practice within CAMHS. The unique experience in forming the“1419” service has important implications nationally and brings together evidence of an effective service within a theoretical underpinned context.