bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Working Memory Impairment in Patients with Non-neuropsychiatric Systemic Lupus Erythematosus: A Blood-oxygen-level Dependent Functional Magnetic Resonance Imaging Study
Authors: Zhu Chun-Min , Ma Ye , Xie Lei , Huang Jin-Zhuang , Sun Zong-Bo , Duan Shou-Xing , Lin Zhi-Rong , Yin Jing-Jing , Le Hong-Bo , Sun Dan-Miao , Xu Wen-Can , Ma Shu-Hua 
Published: January 2017

Objective.Using ethology and functional magnetic resonance imaging (fMRI) to explore mild cognitive dysfunction and spatial working memory (WM) impairment in patients with systemic lupus erythematosus (SLE) without overt neuropsychiatric symptoms (non-NPSLE) and to study whether any clinical biomarkers could serve as predictors of brain dysfunction in this disease.Methods.Eighteen non-NPSLE patients and 18 matched subjects were all tested using the Montreal cognitive assessment scale test and scanned using blood-oxygen-level dependent fMRI while performing the n-back task to investigate the activation intensity of some cognition-related areas.Results.Ethology results showed that non-NPSLE patients had mild cognitive dysfunction and memory dysfunction (p < 0.05). The fMRI scan confirmed a neural network consisting of bilateral dorsolateral prefrontal cortex (DLPFC), premotor area, parietal lobe, and supplementary motor area (SMA)/anterior cingulate cortex (ACC) that was activated during the n-back task, with right hemisphere dominance. However, only the right SMA/ACC showed a load effect in the non-NPSLE group; the activation intensity of most WM-related brain areas for the non-NPSLE group was lower than for the control group under 3 memory loads. Further, we found that the activation intensity of some cognition-related areas, including the bilateral caudate nucleus/insula and hippocampus/parahippocampal gyrus were lower than the control group under the memory loads. An inverse correlation existed between individual activation intensity and disease duration.Conclusion.Non-NPSLE–related brain damage with right DLPFC-posterior parietal lobe and parahippocampal gyrus default network causes impairment of spatial WM and mild cognitive dysfunction. Patients with longer disease duration would be expected to exhibit increased central nervous system damage.
Sleep Disturbances and Neurobehavioral Performance in Juvenile Idiopathic Arthritis
Authors: Ward Teresa M. , Beebe Dean W. , Chen Maida Lynn , Landis Carol A. , Ringold Sarah , Pike Ken , Wallace Carol A. 
Published: January 2017

Objective.To examine the extent of polysomnographic (PSG) sleep disturbances [obstructive apnea hypopnea index (OAHI), number of wake bouts, arousals, periodic limb movements] and the effect of OAHI on neurobehavioral performance in juvenile idiopathic arthritis (JIA) with obstructive sleep apnea (OSA), JIA without OSA, and controls without OSA, adjusting for intelligence quotient (IQ), pain, medications, daytime sleepiness, and wake bouts.Methods.Children 6–11 years, 68 with JIA and 67 controls, underwent 1 night of PSG and completed self-reported daytime sleepiness surveys, multiple sleep latency tests for physiological sleepiness, and neurobehavioral performance tests the next day.Results.Compared with JIA and controls without OSA, mean OAHI and arousals were significantly higher in JIA with OSA (p < 0.001, respectively). In comparison with JIA and controls without OSA, mean simple reaction time and sustained attention were significantly slower in JIA with OSA, adjusting for IQ, pain, any medication, daytime sleepiness, and wake bouts.Conclusion.Elevated OAHI is suggestive of obstructive sleep apnea and a comorbidity in JIA that may predispose children with JIA to daytime sleepiness and impaired neurobehavioral performance.
Fragility Fractures Are Associated with an Increased Risk for Cardiovascular Events in Women and Men with Rheumatoid Arthritis: A Population-based Study
Authors: Ni Mhuircheartaigh Orla , Crowson Cynthia S. , Gabriel Sherine E. , Roger Veronique L. , Melton L. Joseph , Amin Shreyasee 
Published: January 2017

Objective.Women and men with rheumatoid arthritis (RA) have an increased risk for fragility fractures and cardiovascular disease (CVD), each of which has been reported to contribute to excess morbidity and mortality in these patients. Fragility fractures share similar risk factors for CVD but may occur at relatively younger ages in patients with RA. We aimed to determine whether a fragility fracture predicts the development of CVD in women and men with RA.Methods.We studied a population-based cohort with incident RA from 1955 to 2007 and compared it with age- and sex-matched non-RA subjects. We identified fragility fractures and CVD events following the RA incidence/index date, along with relevant risk factors. We used Cox models to examine the association between fractures and the development of CVD, in which fractures and CVD risk factors were modeled as time-dependent covariates.Results.There were 1171 subjects (822 women; 349 men) in each of the RA and non-RA cohorts. Over followup, there were 406 and 346 fragility fractures and 286 and 225 CVD events, respectively. The overall CVD risk was increased significantly for RA subjects following a fragility fracture (HR 1.81, 95% CI 1.38–2.37) but not for non-RA subjects (HR 1.18, 95% CI 0.85–1.63). Results were similar for women and men with RA.Conclusion.Fragility fractures in both women and men with RA are associated with an increased risk for CVD events and should raise an alert to clinicians to target these individuals for further screening and preventive strategies for CVD.
Antimelanoma Differentiation-associated Gene 5 Antibody: Expanding the Clinical Spectrum in North American Patients with Dermatomyositis
Authors: Moghadam-Kia Siamak , Oddis Chester V. , Sato Shinji , Kuwana Masataka , Aggarwal Rohit 
Published: January 2017

Objective.To determine the clinical features associated with the antimelanoma differentiation-associated gene 5 antibody (anti-MDA5) in US patients with clinically amyopathic dermatomyositis (CADM) and classic DM.Methods.Patients with CADM were consecutively selected from the University of Pittsburgh Myositis Database from 1985 to 2013. CADM was defined by a typical DM rash without objective muscle weakness and no or minimal abnormalities of muscle enzymes, electromyography, or muscle biopsy. DM was defined by Bohan and Peter criteria and was 1:1 matched (sex and age ± 5 yrs) to patients with CADM. Anti-MDA5 autoAb levels were determined using ELISA. Clinical features were compared between CADM and DM and between MDA5-positive and MDA5-negative subjects, using chi-squared and/or Mann-Whitney U tests as appropriate.Results.We identified 61 patients with CADM who were matched to 61 DM controls (female 62% vs 64%; mean age 44.8 yrs vs 48.2, p < 0.5). Anti-MDA5 frequency was the same in both cohorts (13.1%), and anti-MDA5 was significantly associated with a higher likelihood of cutaneous ulcers, digital tip ulcerations, and puffy fingers as well as interstitial lung disease (ILD). Most patients with ILD had rapidly progressive ILD (RPILD) leading to early death. Patients with CADM were more likely to have dysphagia, but there were no other clinical differences seen associated with CADM as compared to classic DM.Conclusion.Anti-MDA5 positivity had a similar frequency in US patients with CADM and DM and is associated with ILD, RPILD, cutaneous ulcers, digital tip ulceration, and poor survival.
Sex-specific Relationship of Serum Uric Acid with All-cause Mortality in Adults with Normal Kidney Function: An Observational Study
Authors: Kang Eunjeong , Hwang Seung-sik , Kim Dong Ki , Oh Kook-Hwan , Joo Kwon Wook , Kim Yon Su , Lee Hajeong 
Published: January 2017

Objective.To explain the clinical effect of serum uric acid (SUA) levels as a risk factor for mortality, considering exclusion of kidney function.Methods.Participants aged over 40 years who underwent health checkups were recruited. Individuals with estimated glomerular filtrations rates < 60 ml/min/1.73 m2and who received laboratory study and colonoscopy on the same day were excluded.Results.SUA levels were higher in men than in women (5.7 ± 1.2 mg/dl for men and 4.2 ± 0.9 mg/dl for women, p < 0.001). During 12.3 ± 3.6 years of followup, 1402 deaths occurred among 27,490 participants. About 6.9% of men and 3.1% of women died. The overall mortality rate had a U-shaped association with SUA levels, a U-shaped association in men, and no association in women. There was a significant interaction of sex for the SUA-mortality association (p for interaction = 0.049); therefore, survival analysis was conducted by sex. In men, the lower SUA group had a higher mortality rate after adjustment (SUA ≤ 4.0 mg/dl, adjusted HR 1.413, 95% CI 1.158–1.724, p = 0.001) compared with the reference group (SUA 4.1–6.0 mg/dl). A higher SUA contributed to an insignificant increased mortality in men (> 8.0 mg/dl, adjusted HR 1.140, 95% CI 0.794–1.636, p = 0.479). Women failed to show any significant association between SUA and mortality.Conclusion.This study provided novel evidence that SUA-mortality association differed by sex. We demonstrated that a lower SUA was an independent risk factor for all-cause mortality in men with normal kidney function.
Malignancies in Patients with Anti-RNA Polymerase III Antibodies and Systemic Sclerosis: Analysis of the EULAR Scleroderma Trials and Research Cohort and Possible Recommendations for Screening
Authors: Lazzaroni Maria-Grazia , Cavazzana Ilaria , Colombo Enrico , Dobrota Rucsandra , Hernandez Jasmin , Hesselstrand Roger , Varju Cecilia , Nagy Gabriella , Smith Vanessa , Caramaschi Paola , Riccieri Valeria , Hachulla Eric , Balbir-Gurman Alexandra , Chatelus Emmanuel , Romanowska-Próchnicka Katarzyna , Araújo Ana Carolina , Distler Oliver , Allanore Yannick , Airò Paolo ,   EUSTAR co-authors
Published: January 2017

Objective.To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)− positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients.Methods.(1) Analysis of the EUSTAR database: 4986 patients with information on their anti-RNAP3 status were included. (2) Case-control study: additional retrospective data, including malignancy history, were queried in 13 participating EUSTAR centers; 158 anti-RNAP3+ cases were compared with 199 local anti-RNAP3− controls, matched for sex, cutaneous subset, disease duration, and age at SSc onset. (3) A Delphi exercise was performed by 82 experts to reach consensus for cancer screening in anti-RNAP3+ patients.Results.In the EUSTAR registry, anti-RNAP3 were associated in multivariable analysis with renal crisis and diffuse cutaneous involvement. In the case-control study, anti-RNAP3 were associated with gastric antral vascular ectasia, rapid progression of skin involvement, and malignancies concomitant to SSc onset (OR 7.38, 95% CI 1.61–33.8). When compared with other anti-RNAP3+ patients, those with concomitant malignancies had older age (p < 0.001) and more frequent diffuse cutaneous involvement (p = 0.008). The Delphi exercise highlighted the need for malignancy screening at the time of diagnosis for anti-RNAP3+ patients and tight followup in the following years.Conclusion.Anti-RNAP3+ patients with SSc have a high risk of concomitant malignancy. These results have implications for clinical practice and suggest regular screening for cancer in anti-RNAP3+ patients.
Achieving Consensus on Total Joint Replacement Trial Outcome Reporting Using the OMERACT Filter: Endorsement of the Final Core Domain Set for Total Hip and Total Knee Replacement Trials for Endstage Arthritis
Authors: Singh Jasvinder A. , Dowsey Michelle M. , Dohm Michael , Goodman Susan M. , Leong Amye L. , Scholte Voshaar Marieke M.J.H. , Choong Peter F. 
Published: January 2017

Objective.Discussion and endorsement of the OMERACT total joint replacement (TJR) core domain set for total hip replacement (THR) and total knee replacement (TKR) for endstage arthritis; and next steps for selection of instruments.Methods.The OMERACT TJR working group met at the 2016 meeting at Whistler, British Columbia, Canada. We summarized the previous systematic reviews, the preliminary OMERACT TJR core domain set and results from previous surveys. We discussed preliminary core domains for TJR clinical trials, made modifications, and identified challenges with domain measurement.Results.Working group participants (n = 26) reviewed, clarified, and endorsed each of the inner and middle circle domains and added a range of motion domain to the research agenda. TJR were limited to THR and TKR but included all endstage hip and knee arthritis refractory to medical treatment. Participants overwhelmingly endorsed identification and evaluation of top instruments mapping to the core domains (100%) and use of subscales of validated multidimensional instruments to measure core domains for the TJR clinical trial core measurement set (92%).Conclusion.An OMERACT core domain set for hip/knee TJR trials has been defined and we are selecting instruments to develop the TJR clinical trial core measurement set to serve as a common foundation for harmonizing measures in TJR clinical trials.
Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles
Authors: De-Pablo-Gómez-de-Liaño Lucía , Fernández-Vigo José Ignacio , Ventura-Abreu Néstor , García-Feijóo Julián , Fernández-Vigo José Ángel , Gómez-de-Liaño Rosario 
Published: January 2017

Purpose:
To assess the agreement between two different spectral domain (SD-OCT) and one swept source (SS-OCT) optical coherence tomography device to measure the insertion distance and the thickness of the horizontal rectus muscles.

Methods:
Seventy eyes from 35 healthy patients were studied. Three OCT instruments—Spectralis (Heidelberg Engineering Inc., Heidelberg, Germany), Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA), and Triton (Topcon, Inc., Tokyo, Japan)—were used to measure the limbus insertion distance and the thickness of the lateral rectus and medial rectus muscles. The intraclass correlation coefficient (ICC) was calculated to determine the reproducibility and the agreement between the three methods.

Results:
Measurement of the limbus insertion distance was possible in 100% of cases with the three OCT devices. The thickness could be measured in 75% or more patients with Spectralis, 74% or more with Cirrus, and 78% or more with Triton. The agreement of the insertion distance measurements between the three devices ranged from an ICC of 0.629 or greater to 0.887; for the muscle thickness, the ICC ranged from 0.495 or greater to 0.854. The best agreement existed between the Spectralis and Topcon devices for insertion distance (ICC = 0.715 to 0.887) and for muscle thickness (ICC = 0.641 to 0.854). The reproducibility of each device was good and was higher for insertion distance (ICC = 0.880) than for muscle thickness (ICC = 0.736). The highest reproducibility values were obtained with Triton.

Conclusions:
The three OCT devices permitted accurate and reproducible measurements of the limbus insertion distance and the thickness of the horizontal rectus muscles, showing moderate to good agreement between the SS-OCT and the two SD-OCT instruments.

[
J Pediatr Ophthalmol Strabismus
. 2017;54(3):168–176.]
VARIABILIDADE ESPACIAL E TEMPORAL DOS PARÂMETROS FÍSICO-QUÍMICO EM AMBIENTE LÊNTICO
Authors: Casale Dalla Villa Maria Estela , Sampaio Tony Vinicius Moreira 
Published: January 2017

Este trabalho destaca a importância do conhecimento da variabilidade espaço-temporal dos parâmetros físico-químicos, no ambiente lêntico, em reservatório. Para compreender a variabilidade dos parâmetros físico-químicos é necessário entender a evolução do sistema e como ele reage a diferentes intervenções internas e externas do corpo d’água. Foram selecionados os parâmetros: temperatura da água, oxigênio dissolvido, turbidez e pH, devido a importância deles em qualquer estudo sobre qualidade de um recurso hídrico e também devido a vulnerabilidade a influências internas e externas. O estudo demonstra que não basta apenas a análise dos teores desses parâmetros, é necessário o conhecimento do funcionamento interno do corpo d'água, para poder inter-relacionar com os aspectos externos e assim conhecer a dinâmica da variabilidade espaço temporal dos parâmetros físico-químicos. Com esse conhecimento é possível compartimentar o ambiente aquático e identificar áreas mais impactadas.
QUÍMICA E MINERALOGIA DE UM SOLO DESENVOLVIDO DE BASALTO, COLETADO ATRAVÉS DE SONDAGEM SPT
Authors: Teixeira Raquel Souza , Vendrame Pedro R. S. , Christoni Amanda R. F. , SILVA PAULO R. C. 
Published: January 2017

Os solos desenvolvidos nas regiões tropicais úmidas, formados em ambientes de intensa intemperização química, apresentam atributos devido ao efeito integrado de perda de sílica e concentração de óxidos de Fe e Al, dessilicação e ferralitização, respectivamente. Com o objetivo de contribuir para o entendimento da evolução de um perfil de solo desenvolvido de basalto, foram feitas análises físicas, químicas e mineralógicas de um perfil localizado no Campo Experimental de Engenharia Geotécnica (CEEG), Campus da Universidade Estadual de Londrina (UEL). Para isso, foi realizada uma sondagem profunda do tipo SPT até a profundidade de 15,45 metros. Os resultados permitiram verificar que a granulometria é crescente com a profundidade e o conteúdo de areia é menor nas camadas intermediárias do solo. O conteúdo de C orgânico, pH, cálcio e magnésio trocáveis foram superiores na camada superficial, já para potássio trocável e fósforo disponível, foram verificados valores semelhantes na base e no topo do perfil. A composição mineralógica mostrou-se relativamente homogênea com a profundidade, com presença de quartzo, magnetita, caolinita, gibbsita e hematita.
Recommendations for Best Disinfectant Practices to Reduce the Spread of Infection via Wrestling Mats
Authors: Young Linda Mull , Motz Vicki Abram , Markey Emily R. , Young Suzanne C. , Beaschler Ronald E. 
Published: January 2017

Context:
At the request of the National Wrestling Coaches Association and the head wrestling coach at our university, we conducted a study of infection transmission in collegiate wrestlers.

Objective:
To examine disinfectant effectiveness and develop best-practice guidelines for minimizing the spread of skin infections via wrestling mats.

Design:
Controlled laboratory study and crossover study.

Setting:
Laboratory and two 15-college wrestling invitational meets.

Patients or Other Participants:
A total of 231 collegiate wrestlers and 8 officials.

Intervention(s):
In the laboratory-based part of the study, we measured the bacterial load of mats disinfected with 10% bleach, OxiTitan, Benefect, eWater, and KenClean and inoculated with Staphylococcus epidermidis (strain ATCC 12228) at a concentration of 6.5 × 104 bacteria/cm2. In the empirical part of the study, we used these disinfectants during 2 invitational meets and measured mat and participant bacterial load during competition. Participants were swabbed at weigh-in and after their last bout. Mat bacterial load was monitored hourly.

Main Outcome Measure(s):
We determined total colony counts and species.

Results:
With controlled testing, we observed that products claiming to have residual activity reduced bacterial load by 63% over the course of competition compared with nonresidual agents. Only 4 of 182 participating wrestlers tested positive for methicillin-resistant Staphylococcus aureus, which is the normal population occurrence. The predominant species on mats were skin bacteria (Staphylococcus epidermidis) and substantial levels of respiratory bacteria (Streptococcus pneumoniae), as well as several soil species and a surprisingly low incidence of fecal bacteria (Escherichia coli). Disinfectant effectiveness during the meets was consistent with controlled study findings. Cleaning mats with residual disinfectants reduced the average bacterial load by 76% compared with nonresidual cleaners. Using a footbath did not reduce the bacterial load compared with a bleach-cleaned mat, but using alcohol-based hand gel reduced it by 78%.

Conclusions:
Best practices based on these data include backward mopping of the mats with a residual disinfectant pulled behind the cleaner, allowing mats to dry before walking on them, having wrestlers use hand gel before each bout, and strongly recommending that all wrestlers receive annual influenza vaccinations.
Solid renal masses in adults
Authors: Mittal Mahesh Kumar , Sureka Binit 
Published: January 2017

AbstractWith the ever increasing trend of using cross-section imaging in today's era, incidental detection of small solid renal masses has dramatically multiplied. Coincidentally, the number of asymptomatic benign lesions being detected has also increased. The role of radiologists is not only to identify these lesions, but also go a one step further and accurately characterize various renal masses. Earlier detection of small renal cell carcinomas means identifying at the initial stage which has an impact on prognosis, patient management and healthcare costs. In this review article we share our experience with the typical and atypical solid renal masses encountered in adults in routine daily practice.
Discontinuous splenogonadal fusion diagnosed on computed tomography
Authors: Jakkani Ravikanth , Alhajri Fayzah A , Alteriki Abdullattif , Almuteri Meshari F , Athyal Reji P , Hashem Khaled Z 
Published: January 2017

AbstractSplenogonadal fusion is a very rare congenital anomaly which often manifests as a scrotal mass and rarely as cryptorchidism. It can be of continuous and discontinuous type based on the presence of a band of connecting splenic tissue. We report a rare case of discontinuous type of splenogonadal fusion in an adolescent male presenting as cryptorchidism. We emphasize the computed tomographic findings, which helped us in preoperative diagnosis and aided in appropriate management.
External carotid artery pseudoaneurysm with arteriovenous fistula: A rare complication of glass shrapnel injury
Authors: Saraf Rashmi , Sharma Rajaram , Jaini Lodha V , Mhashal Shashikant 
Published: January 2017

AbstractPosttraumatic external carotid artery pseudoaneurysm with arteriovenous fistula is a rare condition. An 8-year-old child presented with painful pulsatile swelling in the preauricular region following a penetrating glass shrapnel injury. Detailed evaluation showed distal external carotid artery pseudoaneurysm with fistula, which was draining into the retromandibular vein. Endovascular treatment was performed. This case highlights the role of endovascular intervention for such rare complicated vascular pathologies.
Aortic atresia with normal sized left ventricle
Authors: Jagia Priya , Sharma Arun , Gupta Saurabh K , Guleria Munish 
Published: January 2017

AbstractAortic atresia with an associated ventricular septal defect and adequate sized left ventricle is extremely rare. We present two cases in which an alternate diagnosis was suggested on echocardiography because the hypoplastic aortic trunk was missed due to its small caliber. The final diagnosis was, however, clinched on dual source computed tomography, which not only showed the thin aortic trunk but also clearly depicted the coronary artery origins from the hypoplastic aortic root. To the best of our knowledge, use of multi-detector computed tomography in aortic atresia with well developed left ventricle has not been reported in literature till date.