bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate entrepreneurship and market performance
Authors: Jancenelle Vivien E. , Storrud-Barnes Susan , Javalgi Rajshekhar (Raj) G. 
Published: March 2017

PurposeThe purpose of this paper is to investigate the effects of a firm’s entrepreneurial proclivity on market performance for large, publicly traded US firms. This study draws upon the five-dimensional view of corporate entrepreneurship (CE) and develops hypotheses aimed at understanding the effects of direct effect of CE cues of proactiveness, autonomy, innovativeness, competitive aggressiveness and risk-taking on stock performance during earnings conference calls.Design/methodology/approachThe entrepreneurial orientation of 339 firm post-earnings announcement conference calls is analyzed through a content analysis of transcripts, and the impact of CE cues on stock price is measured using event-study methodology.FindingsThe results suggest that the cueing the CE dimensions of innovativeness, risk-taking and especially autonomy have a positive effect on market performance during conference calls, while competitive aggressiveness has a negative effect. No effect was found for proactiveness.Research limitations/implicationsThe effect of entrepreneurial proclivity on firm value is not uniform. Not all dimensions of CE have a positive effect on market performance at a corporate level, and measuring each dimension of CE separately may be a valuable approach for future research.Practical implicationsFirms may create more value when they cue specific entrepreneurial attributes, and cueing competitive aggressiveness may not be desirable.Originality/valueThis study fills a gap in the literature by measuring the direct effect of CE cues on market performance through an innovative research design which relies on computer-aided text analysis.
Case of bullous pemphigoid coexisting with anti‐desmoglein autoantibodies
Authors: Tie Duerna , Yoshida Tokiko , Chinuki Yuko , Da Xia , Ishikawa Noriyoshi , Morita Eishin 
Published: March 2017

AbstractA 79‐year‐old Japanese woman had clinical and histopathological features of bullous pemphigoid, while direct immunofluorescence test revealed C3 and immunoglobulin G depositions in the lower cell surfaces of the epidermis in addition to those in the dermoepidermal junction. Chemiluminescent enzyme immunoassays were positive for desmoglein‐1 and ‐3 antibodies in addition to anti‐BP180 antibodies. In an immunoblotting study, antibodies against both 180‐kDa bullous pemphigoid antigen and 130‐kDa pemphigus vulgaris antigen were detected. Based on these results, bullous pemphigoid coexisting with anti‐desmoglein autoantibodies was diagnosed in this case.
Increased number of mast cells in the dermis in actinic keratosis lesions effectively treated with imiquimod
Authors: Oyama Satomi , Funasaka Yoko , Tsuchiya Shin‐ichi , Kawana Seiji , Saeki Hidehisa 
Published: March 2017

AbstractActinic keratosis (AK) is a cutaneous cancer in situ which develops as a result of excessive exposure to ultraviolet (UV). Toll‐like receptor (TLR)7 agonist imiquimod is a topical immune response modifier and is effective for the treatment of non‐melanoma skin cancers. Recently, the diagnostic role of the dermatoscope has been reported in the course of treatment of AK. In addition, mast cells are now considered to contribute to both the innate and adaptive immune systems in topical imiquimod therapy. We assessed the effect of imiquimod treatment by dermatoscopic and immunohistochemical findings in 14 patients with a total of 21 AK lesions. With the dermatoscope, though the mean erythema score was not significantly different between the cured lesions and the unresponsive lesions, the erythema/red pseudo‐network (“strawberry”) pattern was decreased significantly in the cured lesions. By immunohistochemistry, the number of Ki‐67‐positive proliferative cells in the epidermis was decreased and that of CD117‐positive mast cells in the dermis was increased in the responding lesions. To the best of our knowledge, this is the first study demonstrating that the number of mast cells in the dermis was increased in AK lesions effectively treated with imiquimod. Our present result suggests that mast cells may contribute an antitumor effect in human skin treated with topical imiquimod.
Critical contribution of the interleukin‐6/signal transducer and activator of transcription 3 axis to vasculopathy associated with systemic sclerosis
Authors: Taniguchi Takashi , Asano Yoshihide , Fukasawa Takemichi , Yoshizaki Ayumi , Sato Shinichi 
Published: March 2017

AbstractReflecting the critical role of interleukin (IL)‐6 in systemic sclerosis (SSc), tocilizumab, an anti‐IL‐6 receptor antibody, is currently under a global phase III trial against skin sclerosis of this disease. We here demonstrate that the IL‐6/signal transducer and activator of transcription 3 axis is broadly activated in various cell types in the lesional skin of SSc patients irrespective of disease subtypes, especially in endothelial cells. Importantly, 12 monthly infusions of tocilizumab improved nailfold capillary changes as well as skin sclerosis in a patient with diffuse cutaneous SSc. The present findings suggest a potential disease‐modifying effect of tocilizumab on SSc vasculopathy.
Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus
Authors: Fukumoto Takeshi , Tsuchiyama Shinji , Fukunaga Atsushi , Nishigori Chikako 
Published: March 2017

AbstractUnilateral lichen planus (LP) is a rare clinical variant of LP. The etiology of unilateral LP has not been clarified, although various causes have been reported because of the characteristic distribution. We focused on the contribution of metal allergy and sweating in the development of unilateral LP in this case. To confirm the presence of metal allergy, patch tests with metal allergens were performed. To investigate the cause of the unilateral distribution in unilateral LP, the function of sweating and sweat leaking in the dermis was assessed by a thermoregulatory sweat test and immunohistochemical staining of dermcidin. The patch tests with SnCl2, H2PtCl6, ZnCl2 and MnCl2 were positive. The thermoregulatory sweat test using the starch–iodine method (Minor test) with sweating provoked by heat stimulation revealed hypohidrosis of the affected area, whereas no skin lesions were observed on the dorsal hand and wrist where sweating was normal. Histopathological examination showed keratin plugging of the acrosyringium and lymphocytic infiltrations in the papillary and subpapillary dermis around the intraepidermal and intradermal eccrine duct in the affected area. The immunohistochemical staining of dermcidin confirmed sweat leakage in the subpapillary dermis in the affected area. The symptoms refractory to the topical steroids were markedly improved after removal of the dental metals. The coexistence of metal allergy and sweat leakage in the hypohidrotic area may be involved in the development of unilateral LP.
Robust dual‐sensor data sea‐surface ghost attenuation for quality control purposes
Authors: Caprioli Philippe , Ferber Ralf 
Published: March 2017

ABSTRACTThree‐dimensional receiver ghost attenuation (deghosting) of dual‐sensor towed‐streamer data is straightforward, in principle. In its simplest form, it requires applying a three‐dimensional frequency–wavenumber filter to the vertical component of the particle motion data to correct for the amplitude reduction on the vertical component of non‐normal incidence plane waves before combining with the pressure data. More elaborate techniques use three‐dimensional filters to both components before summation, for example, for ghost wavelet dephasing and mitigation of noise of different strengths on the individual components in optimum deghosting. The problem with all these techniques is, of course, that it is usually impossible to transform the data into the crossline wavenumber domain because of aliasing. Hence, usually, a two‐dimensional version of deghosting is applied to the data in the frequency–inline wavenumber domain. We investigate going down the “dimensionality ladder” one more step to a one‐dimensional weighted summation of the records of the collocated sensors to create an approximate deghosting procedure. We specifically consider amplitude‐balancing weights computed via a standard automatic gain control before summation, reminiscent of a diversity stack of the dual‐sensor recordings. This technique is independent of the actual streamer depth and insensitive to variations in the sea‐surface reflection coefficient. The automatic gain control weights serve two purposes: (i) to approximately correct for the geometric amplitude loss of the Z data and (ii) to mitigate noise strength variations on the two components. Here, Z denotes the vertical component of the velocity of particle motion scaled by the seismic impedance of the near‐sensor water volume. The weights are time‐varying and can also be made frequency‐band dependent, adapting better to frequency variations of the noise. The investigated process is a very robust, almost fully hands‐off, approximate three‐dimensional deghosting step for dual‐sensor data, requiring no spatial filtering and no explicit estimates of noise power. We argue that this technique performs well in terms of ghost attenuation (albeit, not exact ghost removal) and balancing the signal‐to‐noise ratio in the output data. For instances where full three‐dimensional receiver deghosting is the final product, the proposed technique is appropriate for efficient quality control of the data acquired and in aiding the parameterisation of the subsequent deghosting processing.
Effects of Fermented Edible Seeds and Their Products on Human Health: Bioactive Components and Bioactivities
Authors: Gan Ren‐You , Li Hua‐Bin , Gunaratne Anil , Sui Zhong‐Quan , Corke Harold 
Published: March 2017

AbstractThere is a long history of using fermentation in food production. Edible seeds, such as certain beans and cereal grains, are important in the human diet and provide many health benefits. Various microbes, such as lactic acid bacteria, molds, and yeasts, considered as generally recognized as safe (GRAS) microbes, are commonly used to ferment edible seeds and their products. Fermentation can change bioactive components and produce new bioactivities. In order to highlight the importance of fermentation on bioactive components and bioactivities in edible seeds, this review, therefore, summarizes recent relevant studies and discusses fermentation procedures and influences of fermentation on their bioactive components and bioactivities. Overall, fermented edible seeds and their products contain enhanced bioactive components, especially γ‐aminobutyric acid and natural phenolics, and they possess versatile bioactivities, such as antioxidant and anti‐cancer effects, and, therefore, can be recommended as an important part of the human diet, or they can be developed into functional foods to help in the prevention of certain chronic diseases.
Influence of Extrusion Cooking on In Vitro Digestibility, Physical and Sensory Properties of Brazilian Pine Seeds Flour (Araucaria Angustifolia)
Authors: Boff Zortéa‐Guidolin Manoela Estefânea , Piler de Carvalho Carlos Wanderlei , Bueno de Godoy Rossana Catie , Mottin Demiate Ivo , Paula Scheer Agnes 
Published: March 2017

AbstractBrazilian pine seeds (pinhão) are gluten‐free products derived from Araucaria angustifolia. The commercialization of these seeds is essentially associated with a low level of industrialization. In this context, extrusion cooking is a potential alternative for preparing extrudates of pinhão as a food product, which can be easily digested and is ready for human consumption. Brazilian pine seeds flour was processed in a single‐screw extruder following a central composite rotatable design. Three factors (independent parameters) were considered: moisture content (14 to 22 g/100 g), screw speed (100 to 250 rpm), and temperature in the 3rd heating zone (120 to 200 °C). The structural characteristics, in vitro digestibility and sensory acceptance were also evaluated. The resistant starch contents is almost reduced to zero after extrusion cooking while the slowly digestible starch content is increased. An increase in moisture positively affected the hardness and the luminosity (L*), although it negatively affected the volumetric expansion index, crispness, and color parameters (a*, b*, and ΔE). The experimental conditions of this study allowed the production of expanded extrudates from Brazilian pine seeds with good expansion, texture properties, and acceptance qualities. Thus, extrusion cooking was found to be a potential method for the industrialization of Brazilian pine seeds as a food product.
Preparation and Oxidation Stability Evaluation of Tea Polyphenols‐Loaded Inverse Micro‐Emulsion
Authors: Lan Xiaohong , Sun Jingjing , Yang Ying , Chen Mengjie , Liu Jianhua , Wu Jinhong , Wang Zhengwu 
Published: March 2017

AbstractCompared to synthetic antioxidants, tea polyphenols (TPs) has its own advantages in edible oil industry, however, the hydrophilic properties have restricted its applications. In this study, the ternary phase diagram of TPs‐loaded micro‐emulsion (ME) system was constructed, in which glyceryl monooleate (GMO), Tween80, linoleic acid as the surfactants, ethanol as the co‐surfactant and soybean, corn, sunflower oil as the oil phase, have been used for the preparation of ME. The results indicated that a composition of ME (57.5% oil, 18% Tween80, 18% GMO, 4% Linolic acid, and 2.5% water+ethanol) could dissolve maximum water and could stable for 2 mo at room temperature with an average diameter of 6 to 7 nm, as detected by means of dynamic light scattering (DLS). The loaded of TPs into ME led to an increase of particle size to 15 to 16 nm, due to increased polarity of the water phase. The antioxidant capacity of TPs in ME was characterized by the peroxide value (POV) method. The addition of 1% water phase with 0.1 g/mL TPs could retain the POV at low value for 30 d at accelerating temperature 50 °C. Meanwhile, comparing the three edible oil, ME with corn oil has lower conductivity and higher value of POV during the storage. This work provides an efficient and environmentally friendly approach for the preparation of TPs‐loaded ME, which is beneficial to the application of TPs in edible oil.
Will your paper be used in a meta‐analysis? Make the reach of your research broader and longer lasting
Authors: Gerstner Katharina , Moreno‐Mateos David , Gurevitch Jessica , Beckmann Michael , Kambach Stephan , Jones Holly P. , Seppelt Ralf 
Published: March 2017

Summary

Ecological and evolutionary research increasingly uses quantitative synthesis of primary research studies (meta‐analysis) for answering fundamental questions, informing environmental policy and summarizing results for decision makers.

Knowing how meta‐analysis works is important for researchers so that their research can have broader impact. Meta‐analytic thinking encourages scientists to see single primary research studies as substantial contributions to a larger picture.

To facilitate inclusion in a meta‐analysis, relevant primary research studies must be found and basic information about the methods and results must be thoroughly, clearly and transparently reported. While many published papers provide this information, it is common for essential data to be omitted, leading to study exclusion from meta‐analyses.

We provide guidelines for correctly reporting basic data needed from primary studies in ecology and evolutionary biology so that they can be included in meta‐analyses, together with examples that show how data should be reported to enable calculation and analysis of effect sizes, and how data should be made accessible.

These guidelines are important for reporting research results in general, whether or not results are included in subsequent meta‐analyses, because they are necessary for the interpretation and assessment of study outcomes. Increased implementation of these guidelines by authors, editors and publishers, and reinforcement by funders, will foster higher quality and more inclusive syntheses, further the goals of transparency and reproducibility in science, and improve the quality and value of primary research studies.
Lost in parameter space: a road map for stacks
Authors: Paris Josephine R. , Stevens Jamie R. , Catchen Julian M. 
Published: March 2017

Summary

Restriction site‐Associated DNA sequencing (RAD‐seq) has become a widely adopted method for genotyping populations of model and non‐model organisms. Generating a reliable set of loci for downstream analysis requires appropriate use of bioinformatics software, such as the program stacks.

Using three empirical RAD‐seq datasets, we demonstrate a method for optimising a de novo assembly of loci using stacks. By iterating values of the program's main parameters and plotting resultant core metrics for visualisation, researchers can gain a much better understanding of their dataset and select an optimal set of parameters; we present the 80% rule as a generally effective method to select the core parameters for stacks.

Visualisation of the metrics plotted for the three RAD‐seq datasets shows that they differ in the optimal parameters that should be used to maximise the amount of available biological information. We also demonstrate that building loci de novo and then integrating alignment positions is more effective than aligning raw reads directly to a reference genome.

Our methods will help the community in honing the analytical skills necessary to accurately assemble a RAD‐seq dataset.
Nonmydriatic Fundoscopic Imaging Using the Pan Optic iExaminer System in the Pediatric Emergency Department
Authors: Day Lindsay M. , Wang Serena X. , Huang Craig J. 
Published: March 2017

AbstractObjectivesThe primary objective of this study was to determine the percentage of clinically adequate (CA) fundoscopic images that could be obtained using the Pan Optic iExaminer system to perform nonmydriatic fundoscopic imaging in the pediatric emergency department (ED). Secondary objectives were to identify target age groups in which this technology is best utilized and evaluate the overall ease of use in this setting.MethodsChildren 18 years of age or less who presented to the pediatric ED with a non–eye‐related chief complaint were enrolled and stratified by age group (0–2, 2–6, and 6–18 years). Each enrolled patient underwent a bilateral eye examination using the Pan Optic iExaminer system. Images were submitted for review to a pediatric ophthalmologist and were graded based on clarity and field of view. Ease of use was defined as 80% of patients having at least one image of quality to be considered “clinically adequate” for obtaining a full view of the optic nerve, examination time for both eyes 15 minutes or less, and three attempts or less for each eye.ResultsOverall, 91.06% (95% confidence interval [CI] = 86.01% to 96.1%) of children ages 2–18 years had at least one CA image obtained. A total of 16% (95% CI = 7% to 26%) of children 0–2 years, 85% (95% CI = 76% to 94.15%) of children 2–6 years, and 9% (95% CI = 92% to 100%) of 6–18 years had at least one CA image. The median total examination time was 3 minutes 24 seconds (interquartile range = 2 minutes 27 seconds to 4 minutes 49 seconds).ConclusionFundoscopic images were consistently obtained using the Pan Optic iExaminer system in the pediatric ED particularly in children 2–18 years of age. CA images were obtained in children less than 2 years old, but less consistently.
Intravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures: A Systematic Review and Meta‐analysis of Randomized Controlled Trials
Authors: Alshehri Abdussalam , Abulaban Ahmad , Bokhari Rakan , Kojan Suleiman , Alsalamah Majid , Ferwana Mazen , Murad Mohammad Hassan 
Published: March 2017

AbstractBackgroundThe acquisition of intravenous (IV) access in the actively convulsing patient is difficult. This often delays the administration of the IV benzodiazepine (BDZ) necessary for seizure cessation. Delays in seizure cessation are associated with increased pharmacoresistance, increased risk of neuronal injury, worse patient outcomes, and increased morbidity.ObjectiveThe objective was to assess whether the delay imposed by IV access acquisition is justified by improved outcomes. We compared IV versus non‐IV BDZ efficacy in the real world with regard to failure rates (primary outcome), interval to seizure control, and observed complications (secondary outcomes).MethodsA systematic review was performed using Medline, Embase, and the Cochrane Library. All studies published or in press from the inception of the respective database to July 2016 were included. Only randomized and quasi‐randomized controlled trials directly comparing IV to non‐IV (buccal, rectal, intranasal, or intramuscular) BDZ were included.ResultsOur search strategy retrieved 2,604 citations for review. A total of 11 studies were finally included in qualitative synthesis and 10 in quantitative analysis. Only one was of high quality. For treatment failure, non‐IV BDZ was superior to IV BDZ (odd ratio [OR] = 0.72; 95% confidence interval [CI] = 0.56–0.92). However, no significant difference was found between the two treatments in the pediatric subgroup (OR = 1.16; 95% CI = 0.74–1.81). Non‐IV BDZ was administered faster than IV BDZ and therefore controlled seizures faster (mean difference = 3.41 minutes; 95% CI = 1.69–5.13 minutes) despite a longer interval between drug administration and seizure cessation (mean difference = 0.74 minutes; 95% CI = 0.52–0.95 minutes). Respiratory complications requiring intervention were similar between non‐IV BDZ and IV BDZ, regardless of administration route (risk difference = 0.00; 95% CI = –0.02 to 0.01).ConclusionNon‐IV BDZ, compared to IV BDZ, terminate seizures faster and have a superior efficacy and side effect profile. Higher‐quality studies and further evaluation in different age groups are warranted.
Effects of ovarian structures identified at Ovsynch™ enrolment, disease history and lactation variables on odds of pregnancy to a fixed‐time artificial insemination after Ovsynch™
Authors: Ingenhoff L , Hall E , Ranjbar NI S , House JK 
Published: March 2017

ObjectiveTo determine the effects of ovarian structures present at Ovsynch™ enrolment, disease history, lactation variables and times bred on pregnancy per fixed‐time artificial insemination (FTAI) following fixed‐time insemination after Ovsynch and to determine the relationship between the size of ovarian follicular structures and concurrent presence of a corpus luteum (CL).MethodsThe study was conducted in a 3000‐cow Holstein dairy herd. Over a 6‐month period, 886 non‐pregnant cows were examined by transrectal ultrasound and enrolled into 1132 Ovsynch events. Enrolled cows were synchronised using an Ovsynch‐56 protocol. At enrolment, both ovaries were scanned by transrectal ultrasound to identify and record the presence and size of ovarian structures. Cows that did not return to oestrus were pregnancy tested 32–38 days post‐insemination. Univariable and multivariable generalised linear mixed models (GLMMs) were used to determine the effect of each variable on pregnancy per FTAI. A univariable GLMM was also used to analyse the relationship between size of the dominant follicular structure and concurrent presence of a CL.Results
CL size (P = 0.039) and presence of a luteal cyst (P = 0.002) at Ovsynch enrolment significantly increased the odds of pregnancy. Occurrence of lameness (P = 0.035) or mastitis (P = 0.008) between calving and enrolment significantly decreased the odds of pregnancy. Neither the presence nor size of a follicular structure significantly affected the odds of pregnancy, although cows with larger follicular structures were less likely to have a concurrent CL (P < 0.001).ConclusionPresence of luteal tissue at Ovsynch enrolment and recent disease events affected pregnancy per FTAI in cows inseminated after Ovsynch.