bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical Paper Analytical Devices Fabricated Using the Principles of Quilling and Kirigami
Authors: Gao Bingbing , Chi Junjie , Liu Hong , Gu Zhongze 
Published: July 2017

AbstractHere we report the vertical paper analytical devices (vPADs) fabricated using the principles of quilling and kirigami. What differentiates the vPADs from conventional paper microfluidic devices is that the paper substrate used to fabricate the device is placed vertically to the device plane. The fabrication of vPADs with high precision is instrument-free, requiring no photolithography, printing or heating. Two- and three-dimensional vPADs are fabricated for multiplex colorimetric assays of four biochemical indicators and automated enzyme-linked immunosorbent assay of human myoglobin, respectively.
ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis
Authors: Alflen Astrid , Prüfer Steve , Ebner Katharina , Reuter Sebastian , Aranda Lopez Pamela , Scharrer Inge , Banno Fumiaki , Stassen Michael , Schild Hansjörg , Jurk Kerstin , Bosmann Markus , Beckert Hendrik , Radsak Markus P. 
Published: July 2017

AbstractVon Willebrand factor (VWF) is secreted as an acute phase protein during inflammation. ADAMTS-13 regulates the size and prothrombotic activity of VWF by it’s specific proteolytic activity. To determine the relevance of this regulatory pathway for the innate inflammatory response by polymorphonuclear neutrophils (PMN), we employed a mouse model of invasive pulmonary aspergillosis (IPA) where PMN functionality is crucial for fungal clearance and survival. IPA was induced by intratracheal application of Aspergillus fumigatus (A. fumigatus) conidia in wildtype (129/Sv/Pas) or ADAMTS-13 deficient (Adamts13−/−) mice. While neutropenic mice developed lethal IPA, all wildtype mice survived the infection. In contrast to wildtype or VWF deficient mice, Adamts13−/− mice displayed more severe signs of disease with a lethal course in 24% with an increased fungal burden and signs of acute lung injury. Histology sections demonstrated a more pronounced perivascular leukocyte infiltration in support of a dysregulated inflammatory response in Adamts13−/− mice. Importantly, we observed no general defect in the activation of neutrophil functions in response to conidia or hyphae in vitro. Therefore, we conclude that the proteolytic regulation of VWF by ADAMTS-13 or ADAMTS-13 by itself is an important mechanism to control PMN recruitment in acute inflammatory processes, such as fungal pneumonias.
Controlling Plateau-Rayleigh instabilities during the reorganization of silicon macropores in the Silicon Millefeuille process
Authors: Garín M. , Jin C. , Cardador D. , Trifonov T. , Alcubilla R. 
Published: July 2017

AbstractThe reorganization through high-temperature annealing of closely-packed pore arrays can be exploited to create ultra-thin (<20 µm) monocrystalline silicon layers that can work as cheap and flexible substrates for both the electronic and the photovoltaic industries. By introducing a periodic diameter modulation along deep etched pores, many thin layers can be produced from a single substrate and in a single technological process. Besides the periodicity, the exact shape of the modulation also has a profound impact on the process and subtle profile changes can lead to important differences on the process outcome. In this paper we study both theoretically and experimentally the effect of the initial profile on the pore reorganization dynamics and the morphology of the thin layers obtained through annealing. We show that process reliability, annealing time and final layer characteristics, all can be engineered and optimized by precisely controlling the initial pore profile.
SERS Investigation of Cancer Cells Treated with PDT: Quantification of Cell Survival and Follow-up
Authors: Veloso A. B. , Longo J. P. F. , Muehlmann L. A. , Tollstadius B. F. , Souza P. E. N. , Azevedo R. B. , Morais P. C. , da Silva S. W. 
Published: July 2017

AbstractIn this study Surface Enhanced Raman Spectroscopy (SERS) data recorded from mouse mammary glands cancer cells (4T1 cell line) was used to assess information regarding differences between control, death and viable cells after Photodynamic Therapy (PDT) treatment. The treatment used nanoemulsions (NE/PS) loaded with different chloroaluminumphthalocyanine (ClAlP) photosensitizer (PS) contents (5 and 10 µmol × L−1) and illumination (660 nm wavelength) at 10 J × cm−2 (10 minutes). The SERS data revealed significant molecular alterations in proteins and lipids due to the PDT treatment. Principal Component Analysis (PCA) was applied to analyze the data recorded. Three-dimensional and well reproductive PCA scatter plots were obtained, revealing that two clusters of dead cells were well separated from one another and from control cluster. Overlap between two clusters of viable cells was observed, though well separated from control cluster. Moreover, the data analysis also pointed out necrosis as the main cell death mechanism induced by the PDT, in agreement with the literature. Finally, Raman modes peaking at 608 cm−1 (proteins) and 1231 cm−1 (lipids) can be selected for follow up of survival rate of neoplastic cells after PDT. We envisage that this finding is key to contribute to a quick development of quantitative infrared thermography imaging.
What Hong-Ou-Mandel interference says on two-photon frequency entanglement
Authors: Barbieri Marco , Roccia Emanuele , Mancino Luca , Sbroscia Marco , Gianani Ilaria , Sciarrino Fabio 
Published: July 2017

AbstractNot much, in the end. Here we put forward some considerations on how Hong-Ou-Mandel interferometry provides signatures of frequency entanglement in the two-photon state produced by parametric down-conversion. We find that some quantitative information can be inferred in the limit of long-pulse pumping, while the short-pulse limit remains elusive.
Heterogeneous TiO2@Nb2O5 composite as a high-performance anode for lithium-ion batteries
Authors: Liu Yubin , Lin Liwei , Zhang Weifeng , Wei Mingdeng 
Published: July 2017

AbstractHeterogeneous TiO2@Nb2O5 composites, in which TiO2 nanoparticles were evenly embedded on ultrathin Nb2O5 nanosheets, were used as anode materials for LIBs and demonstrated high capacities and excellent rate capability. For instance, this material displayed large capacities of 166.3 and 129.1 mA h g−1 at current densities of 1 A g−1 after 100 cycles and 5 A g−1 after 300 cycles, respectively.
Plasmon-Enhanced Photoelectrochemical Current and Hydrogen Production of (MoS2-TiO2)/Au Hybrids
Authors: Li Ying-Ying , Wang Jia-Hong , Luo Zhi-Jun , Chen Kai , Cheng Zi-Qiang , Ma Liang , Ding Si-Jing , Zhou Li , Wang Qu-Quan 
Published: July 2017

AbstractThree component hybrid (MoS2-TiO2)/Au substrate is fabricated by loading plasmonic Au nanorods on the MoS2 nanosheets coated TiO2 nanorod arrays. It is used for photoelectrochemical (PEC) cell and photocatalyst for hydrogen generation. Owing to the charge transfer between the MoS2-TiO2 hetero-structure, the PEC current density and hydrogen generation of TiO2 nanoarrays are enhanced 2.8 and 2.6 times. The broadband photochemical properties are further enhanced after Au nanorods loading. The plasmon resonance of Au nanorods provides more effective light-harvesting, induces hot-electron injection, and accelerates photo-excited charges separation. The results have suggested a route to construct nanohybrid by combining one-dimensional arrays and two-dimensional nanosheets, meanwhile have successfully utilized plasmonic nanorods as a sensitizer to improve the photochemical properties of the semiconductor nanocomposite.
Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNALys UUU modifications
Authors: Villahermosa Desirée , Fleck Oliver 
Published: July 2017

AbstractEfficient protein synthesis in eukaryotes requires diphthamide modification of translation elongation factor eEF2 and wobble uridine modifications of tRNAs. In higher eukaryotes, these processes are important for preventing neurological and developmental defects and cancer. In this study, we usedSchizosaccharomyces pombeas a model to analyse mutants defective in eEF2 modification (dph1Δ), in tRNA modifications (elp3Δ), or both (dph3Δ) for sensitivity to cytotoxic agents and thermal stress. Thedph3Δandelp3Δmutants were sensitive to a range of drugs and had growth defects at low temperature.dph3Δwas epistatic withdph1Δfor sensitivity to hydroxyurea and methyl methanesulfonate, and withelp3Δfor methyl methanesulfonate and growth at 16 °C. Thedph1Δanddph3Δdeletions rescued growth defects ofelp3Δin response to thiabendazole and at 37 °C. Elevated tRNALysUUUlevels suppressed theelp3Δphenotypes and some of thedph3Δphenotypes, indicating that lack of tRNALysUUUmodifications were responsible. Furthermore, we found positive genetic interactions ofelp3Δanddph3Δwithsty1Δandatf1Δ, indicating that Elp3/Dph3-dependent tRNA modifications are important for efficient biosynthesis of key factors required for accurate responses to cytotoxic stress conditions.
Effects of irrigation water salinity on evapotranspiration modified by leaching fractions in hot pepper plants
Authors: Qiu Rangjian , Liu Chunwei , Wang Zhenchang , Yang Zaiqiang , Jing Yuanshu 
Published: July 2017

AbstractWe investigated whether leaching fraction (LF) is able to modify the effects of irrigation water salinity (ECiw) on evapotranspiration (ET). We conducted an experiment with a completely randomized block design using five levels of ECiw and two LFs. Results showed that the electrical conductivity of drainage water (ECdw) in an LF of 0.29 was considerably higher during the 21–36 days after transplanting (DAT), and considerably lower after 50 DAT than in an LF of 0.17. The hourly, nighttime, daily, cumulative and seasonal ET all decreased considerably as a result of an increase in the ECiw. The daily ET started to be considerably higher in the LF of 0.29 than in the LF of 0.17 from 65 DAT. Compared with the LF of 0.17, the seasonal ET in the LF of 0.29 under various ECiw levels increased by 4.8%–8.7%. The Maas and Hoffman and van Genuchten and Hoffman models both corresponded well with the measured relative seasonal ET and the LF had no marked effects on these model parameters. Collectively, an increase in the level of ECiw always decreased the ET substantially. An increase in the LF increased the ET considerably, but there was a time lag.
Two new species of Endocarpon (Verrucariaceae, Ascomycota) from China
Authors: Zhang Tao , Liu Meng , Wang Yan-Yan , Wang Zhi-Jun , Wei Xin-Li , Wei Jiang-Chun 
Published: July 2017

AbstractEndocarpon species are key components of biological soil crusts. Phenotypic and systematic molecular analyses were carried out to identify samples of Endocarpon collected from the southeast edge of the Tengger Desert in China. These morphological and molecular analyses revealed two previously undescribed species that form highly supported independent monophyletic clades within Endocarpon. The new taxa were named Endocarpon deserticola sp. nov. and E. unifoliatum sp. nov. Furthermore, our results indicated that the newly developed protein coding markers adenylate kinase (ADK) and ubiquitin-conjugating enzyme h (UCEH) are useful for assessing species boundaries in phylogenic analyses.
Non-invasive in vivo determination of viable islet graft volume by 111In-exendin-3
Authors: Eter Wael A. , Van der Kroon Inge , Andralojc Karolina , Buitinga Mijke , Willekens Stefanie M. A. , Frielink Cathelijne , Bos Desiree , Joosten Lieke , Boerman Otto C. , Brom Maarten , Gotthardt Martin 
Published: July 2017

AbstractPancreatic islet transplantation is a promising therapy for patients with type 1 diabetes. However, the duration of long-term graft survival is limited due to inflammatory as well as non-inflammatory processes and routine clinical tests are not suitable to monitor islet survival. 111In-exendin-SPECT (single photon emission computed tomography) is a promising method to non-invasively image islets after transplantation and has the potential to help improve the clinical outcome. Whether 111In-exendin-SPECT allows detecting small differences in beta-cell mass (BCM) and measuring the actual volume of islets that were successfully engrafted has yet to be demonstrated. Here, we evaluated the performance of 111In-exendin-SPECT using an intramuscular islet transplantation model in C3H mice. In vivo imaging of animals transplanted with 50, 100, 200, 400 and 800 islets revealed an excellent linear correlation between SPECT quantification of 111In-exendin uptake and insulin-positive area of islet transplants, demonstrating that 111In-exendin-SPECT specifically and accurately measures BCM. The high sensitivity of the method allowed measuring small differences in graft volumes, including grafts that contained less than 50 islets. The presented method is reliable, convenient and holds great potential for non-invasive monitoring of BCM after islet transplantation in humans.
Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells
Authors: Han Shiwen , Sun Lu , He Feng , Che Huilian 
Published: July 2017

AbstractGlycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reactionin vivoandin vitro. Active systemic allergic reaction in Balb/c mice showed that GA can suppress the increased level of IL-4 to restore the immune balance of TH1/TH2 cells in a dose-dependent manner. Additionally, GA attenuated significantly the B cells producing allergen-specific IgE and IgG1partly because of the low levels of TH2 cytokines. Both passive cutaneous anaphylaxisin vivoand an RBL-2H3 cell-based immunological assayin vitroindicated that GA acted as a “mast cell stabilizer”, as it inhibited mast cell degranulation and decreased vascular permeability by inhibiting the expression of Orai1, STIM1 and TRPC1, which blocked extracellular Ca2+influxes. The current study suggests that GA may serve as an effective anti-allergic agent derived from food for the prevention and treatment of IgE-mediated allergic reaction.
Parallel Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation in a Patient with a Preexisting Unsalvageable Occluded TIPS and Refractory Variceal Bleeding
Authors: Rathod Krantikumar , Popat Bhavesh , Barai Pankaj , Amrapurkar Deepak 
Published: July 2017

AbstractTransjugular intrahepatic portosystemic shun (TIPS) dysfunction is usually secondary to acute thrombosis within the stent, pseudointimal hyperplasia in the TIPS parenchymal tract, or intimal hyperplasia in the outflow hepatic vein. Several methods have been used in treating TIPS dysfunction, including balloon angioplasty, stent insertion, and the creation of a parallel TIPS. We report a case of refractory variceal bleeding in which a parallel TIPS was successfully created after failure to recanalize the preexisting occluded TIPS.
Balloon Entrapment: An Unusual Complication of Detachable Balloon Embolization of Traumatic Caroticocavernous Fistula
Authors: Kannath Santhosh , Rajan Jayadevan 
Published: July 2017

AbstractTraumatic caroticocavernous fistula was attempted to embolize using detachable balloons. Though the fistula could be occluded, unexpected complication was observed during the detachment of the balloon, and the fistula was later tackled using coils and liquid embolic agent. Failure analysis revealed an interesting correlation between the anatomy of sac and the course of the balloon mounted microcatheter.
Renal Cell Carcinoma Embolization for the Treatment of Budd–Chiari Syndrome
Authors: Allison Stephen , Johnson Guy , Kogut Matthew , Monroe Eric 
Published: July 2017

AbstractRenal cell carcinoma (RCC) is the eighth most common malignancy, accounting for 3% of all newly diagnosed neoplasms. RCC venous invasion occurs in 4 to 10% of cases. We report a case of RCC with extensive vascular invasion and new-onset liver dysfunction. The etiology of the liver dysfunction was attributed to hepatic vein obstruction; herein we describe the first reported case of transcatheter embolization of RCC for Budd–Chiari syndrome.
Simultaneous Percutaneous Alcohol Ablation of Pulmonary and Hepatic Hydatid Cysts: “PAIR” in a Pair
Authors: Chauhan Udit , Puri Sunil , Jain Neeraj , Pargewar Sudheer , Goel Vandana 
Published: July 2017

AbstractWe present a 48-year-old lady with left chest pain and dyspnea of 6 months duration. Computed tomography scan revealed a left-sided cystic lesion in the lung parenchyma abutting the posterior pleura and chest wall along with a similar cystic lesion in the segment IV of the liver. A diagnosis of lung and liver hydatid cysts was made based on the imaging and positive serology. Percutaneous alcohol ablation of the lung and hepatic hydatid cysts was done using catheter drainage (PAIR-D: percutaneous aspiration, instillation of scolicidal agents, reaspiration of contents, and drainage) in the lung cyst and needle-PAIR in the liver lesion. The procedure was well tolerated without any intra- as well as postprocedure complication. The patient is well during 24 months follow-up without any recurrence or morbidity.
Temporary Biliary Stent Placement for Benign Stricture with Laparoscopic-Assisted Endoscopic Stent Retrieval in a Patient Status Post Roux-en-Y Gastric Bypass: A Multidisciplinary Approach to a Complex Condition
Authors: Anton Kevin , Khara Harshit , Bhanushali Ashok 
Published: July 2017

AbstractBenign biliary strictures are multifactorial in etiology and can be difficult to treat, causing significant morbidity and mortality. In patients with prior upper gastrointestinal surgery, such as Roux-en-Y gastric bypass, options for intervention are limited by the inability of an endoscope to reach the biliary ductal system due to altered anatomy. In patients with an inaccessible ductal system by endoscopic retrograde cholangiopancreatography (ERCP), percutaneous bile duct stent placement for benign strictures has traditionally been reserved for cases of failed cholangioplasty without additional surgical options. Our case details a novel multidisciplinary management approach for the treatment of a refractory biliary stricture in a patient with Roux-en-Y gastric bypass anatomy with remnant gastrectomy. Following interventional radiology-guided retrievable biliary stent placement and subsequent remodeling, laparoscopy-assisted ERCP with stent retrieval was performed through the combined efforts of minimally invasive surgery and gastroenterology.
Evolution of Osteochondritis Dissecans of the Lateral Femoral Condyle Combined with Discoid Meniscus
Authors: Bulgheroni Erica , Mattioli Lorenzo , Bulgheroni Paolo 
Published: July 2017

AbstractThe discoid meniscus is a rare anomaly of the knee that affects mostly the lateral meniscus and is often asymptomatic. The osteochondritis dissecans is a disorder of the subchondral bone and articular cartilage and occurs frequently associated with the discoid lateral meniscus. In the present case, we showed the evolution of this association related to surgical treatment. A patient with lateral knee pain and a magnetic resonance depicting a torn discoid lateral meniscus and osteochondritis dissecans of the lateral femoral condyle was treated with partial meniscectomy and meniscal sutures. After 1 year, the symptoms reappeared, and a new meniscal repair was performed to treat a bucket-handle tear, while cartilage was apparently intact. After 4 years, there was a new recurrence of symptoms, and the knee developed a valgus deformity. Cartilage was treated with microfractures, and a subsequent distal femoral osteotomy associated with lateral meniscal scaffold was performed. The patient was followed up clinically, with radiographs and magnetic resonance for 5 years with an improvement of the results up to 2 years and no signs of deterioration of results over time.
Two-Stage Treatment of a Large Pelvic Cystic Pseudotumor in a Metal-On-Metal Total Hip Arthroplasty
Authors: Cottino Umberto , Dettoni Federico , Risitano Salvatore , Marmotti Antonio , Rossi Roberto 
Published: July 2017

AbstractThe authors report a case of a huge cystic pseudotumor, surrounding a failed metal-on-metal total hip arthroplasty (THA). The cyst surrounded the hip anteriorly, occupied part of the anterior portion of the thigh, and extended to the anterolateral aspect of the abdomen. The case was treated by a two-stage procedure. The first stage consisted of a percutaneous drainage of the fluid content of the cyst (∼1,200 mL). This procedure reduced the risk of tearing the cyst capsule spreading the liquid in the tissues surrounding the THA, and in the abdomen. Thanks to this simple procedure, the second stage treatment consisted of a relatively usual THA revision. The patient recovered completely from the treatment and returned to pain-free full activities of daily living.
Determinants and Evaluation of Nasal Airflow Perception
Authors: Hur Kevin , Zhao Kai , Leopold Donald , Wrobel Bozena , Shen Jasper 
Published: July 2017

AbstractThe sensation of nasal airflow, or nasal airway patency, is an important consideration in the treatment outcome of nasal airway obstruction. Clinicians striving to optimize the nasal passageway have relied on techniques aimed at decreasing peak airway resistance across nasal valves. Nonetheless, the evaluation of the nasal airway is multifaceted, and the objective determinants of subjective nasal patency remain incompletely elucidated. While rhinomanometry, peak nasal inspiratory airflow, and acoustic rhinometry have traditionally been used in research to focus on resistance as a measure of patency, an emerging body of evidence suggests that subjective nasal patency is more significantly correlated to the dynamic change of nasal mucosal temperature. The objective of this review is to provide the technical background on nasal airflow perception and intranasal trigeminal function as crucial to those performing functional and aesthetic rhinosurgery.
Objective Assessment of Nasal Patency
Authors: Giotakis Aristeidis , Tomazic Peter , Riechelmann Herbert , Vent Julia 
Published: July 2017

AbstractThe aim to objectify nasal airflow and patency is ongoing—many methods have been suggested, often lacking clinical relevance or showing weak correlations with patients' symptoms. It is crucial to thoroughly consult our patients presenting with nasal obstruction—and to inform them about realistic possible surgical outcomes. Often, a perfect-looking internal nose with a straight septum and normal-appearing turbinates does not guarantee a happy, symptom-free “owner.” A review of the literature and the current technical market is presented here to facilitate the rhinosurgeon's decision to perform pre- and postoperative objective measurements of nasal airflow. Recommendations by the societies have been included.
Classical genetics and breeding.
Authors: Batlle I. , Dicenta F. , Socias i Company R. , Gradziel T. M. , Wirthensohn M. , Duval H. , Vargas F. J. 
Published: July 2017

Abstract

This chapter describes almond germplasm and genetics, including ploidy, genome size, inheritance of qualitative characters and heritability of quantitative traits. The objectives, methodology, achievements and prospects of breeding programmes are discussed. Major breeding objectives include productivity, self-compatibility, late blooming time, kernel quality, tree architecture, and disease and pest resistance. There is a long-standing dilemma affecting tree crops, which partially affects almond breeding: despite extensive genetic improvement efforts, commercial production remains dominated by a few elite and usually old cultivars.