bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Wisdom and Sustainability: Dealing with Instability
Authors: Intezari Ali 
Published: November 2015

AbstractA thorough review of the literature reveals that there is a paucity of studies on integrating wisdom and sustainability disciplines. This paper investigates the role of sustainability in fostering wisdom in the interaction between businesses and their surrounding environment. Wisdom has recently attracted a lot of attention in both academia and the practical world. However, despite the strong emphasis that is put on the necessity of incorporating wisdom into business practices, there is little on how wisdom can be practically integrated in the real business world. To address this issue, this paper draws a linkage between wisdom and sustainability by noting the assumptions that the concepts of wisdom and sustainability share with respect to human flourishing, environmental preservation and economic growth. It is concluded that wisdom manifests through organizational sustainability, and that wisdom promotes organizational sustainability capacity. A model of the interaction between the two practices is proposed. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Reconceptualizing Power Relations as Sustainable Business Practice
Authors: Bolton Dianne , Landells Terry 
Published: November 2015

AbstractThe concept of ‘sustainable development’ has brought diverse stakeholders together to consider approaches to economic development. Thus, the possibility of irreconcilable tensions between ‘sustainability’ and ‘economic development’ has been identified, together with an apparent domination of the discourse on ‘sustainable development’ by corporations. In relation to this latter claim and mindful of Foucault's tenet that power also comes from below, we suggest that alternative ‘voices’ significant to the discourse should not be jettisoned because they are ‘managerial’ or ‘corporate’. This argument focuses on the significance of ‘voice’ generated by managers taking strategic action with salient stakeholders. Given increasing strategic ambiguity, managers are leveraging broad stakeholder knowledge and input to achieve credible strategic outcomes that stakeholders can accommodate. We contend that the relationship between knowledge and power is significant in the discourse on sustainable development and that knowledge generated by stakeholder collaboration be recognized as an alternative ‘voice’. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
The Implementation of Authentic Sustainable Strategies: i‐SITE Middle Managers, Employees and the Delivery of 100% Pure New Zealand
Authors: Morrow Jeremy , Mowatt Simon 
Published: November 2015

AbstractThis paper examines the processes by which 100% Pure New Zealand is translated into action by middle managers and employees at the point of contact with consumers at i‐SITEs. Within the tourism industry, organizations that differentiate employing ‘green' and ‘authentic' imagery of the natural environment highlight the importance of the active participation and engagement of middle managers and employees whose actions are observable to consumers. However, there has been little previous research on how employees understand concepts of sustainability and authenticity, or how their own views and values support embedding strategy. These issues were examined with a multiple case study methodology. Thematic analysis identified three barriers to authentic implementation: failure to support bottom‐up policy engagement, unclear top‐down communication of strategic priorities, and perceived lack of strategic vision and commitment. The paper suggests that organization‐wide vision and commitment are required to implement authentic sustainability strategies. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Poly(3,4‐dimethyl‐5‐vinylthiazolium)/DBU‐Catalyzed Thioesterification of Aldehydes with Thiols
Authors: Chung Junyong , Seo Ue Ryung , Chun Supill , Chung Young Keun 
Published: November 2015

AbstractPoly(3,4‐dimethyl‐5‐vinylthiazolium) was synthesized from 3,4‐dimethyl‐5‐vinylthiazole through free radical polymerization and was examined as polymer precatalysts in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) for the thioesterification of aldehydes with thiols. The poly(5‐vinylthiazolium)/DBU had excellent catalytic activity and could be reused 10 times without a considerable loss of activity.
On the influence of data noise and uncertainty on ordering of objects, described by a multi‐indicator system. A set of pesticides as an exemplary case
Authors: Carlsen Lars , Bruggemann Rainer 
Published: November 2015

AbstractA priori in partial ordering methodology the input data are understood as exact and true values, which is denoted as the “original data matrix”. As such even minor differences between values are regarded as real. However, in real life data are typically associated with a certain portion of noise or uncertainty. Hence, introducing noise may cause changes in the overall ordering of objects. The present paper deals with the effects of data noise or uncertainties on the partial ordering of a series of objects, a series of obsolete pesticides being used as an illustrative example. The approach is fuzzy like, and partially ordered sets are obtained as function of noise. A main focus of the work is to identify the range in terms of noise, where the original partial order is retained. We call this range the “stability range”. It is demonstrated that by increasing data noise the range where the “original partial order” is obtained decreases. The original partial order is based on the original data matrix. Further, it is found that significant changes in the partial ordering appear outside of this stability range. The possible relation between data noise and the stability range is discussed on an empirical basis. Copyright © 2015 John Wiley & Sons, Ltd.
Binding of Reactive Oxygen Species at FeS Cubane Clusters
Authors: Bruska Marta K. , Stiebritz Martin T. , Reiher Markus 
Published: November 2015

AbstractReactive oxygen species (ROS) play an important role in the biochemistry of the cell and occur in degenerative processes as well as in signal transduction. Ironsulfur proteins are particularly oxygen‐sensitive and their inorganic cofactors frequently undergo ROS‐induced decomposition reactions. As experimental knowledge about these processes is still incomplete we present here a quantum chemical study of the relative energetics for the binding of the most relevant ROS to [Fe4S4] clusters. We find that cubane clusters with one uncoordinated Fe atom (as found, for instance, in aconitase) bind all oxygen derivatives considered, whereas activation of triplet O2 to singlet O2 is required for binding to valence‐saturated iron centers in these clusters. The radicals NO and OH feature the most exothermic binding energies to Fe atoms. Direct sulfoxidation of coordinating cysteine residues is only possible by OH or H2O2 as attacking agents. The thermodynamic picture of ROS binding to ironsulfur clusters established here can serve as a starting point for studying reactivity‐modulating effects of the cluster‐embedding protein environment on ROS‐induced decomposition of ironsulfur proteins.
The Control of Conjugation Lengths and Steric Hindrance to Modulate Aggregation‐Induced Emission with High Electroluminescence Properties and Interesting Optical Properties
Authors: Xue Miao‐Miao , Xie Yue‐Min , Cui Lin‐Song , Liu Xiang‐Yang , Yuan Xiao‐Dong , Li Yong‐Xi , Jiang Zuo‐Quan , Liao Liang‐Sheng 
Published: November 2015

AbstractA series of novel AIE‐active (aggregation‐induced emission) molecules, named SAF‐2‐TriPE, SAF‐3‐TriPE, and SAF‐4‐TriPE, were designed and synthesized through facile reaction procedures. We found that incorporation of the spiro‐acridine‐fluorene (SAF) group, which is famous for its excellent hole‐transporting ability and rigid structure, at different substitution positions on the phenyl ring affected the conjugation lengths of these compounds. Consequently, we have obtained molecules with different emission colors and properties without sacrificing good EL (electroluminescence) characteristics. Accordingly, a device that was based on compound SAF‐2‐TriPE displayed superior EL characteristics: it emitted green light with ηc, max=10.5 cd A−1 and ηext, max=4.22 %, whereas a device that was based on compound SAF‐3‐TriPE emitted blue‐green light with ηc, max=3.9 cd A−1 and ηext, max= 1.71 %. These compounds also displayed different AIE performances: when the fraction of water in the THF solutions of these compounds was increased, we observed a significant improvement in the ΦF of compounds SAF‐2‐TriPE and SAF‐3‐TriPE; in contrast, compound SAF‐4‐TriPE showed an abnormal phenomenon, in that it emitted a strong fluorescence in both pure THF solution and in the aggregated state without a significant change in ΦF. Overall, this systematic study confirmed a relationship between the regioisomerism of the luminophore structure and its AIE activity and the resulting electroluminescent performance in non‐doped devices.
Preparation of Mesoporous Bimetallic Au–Pt with a Phase‐Segregated Heterostructure Using Mesoporous Silica
Authors: Kitahara Masaki , Kubara Saori , Takai Azusa , Takimoto Daisuke , Enomoto Shinpei , Yamauchi Yusuke , Sugimoto Wataru , Kuroda Kazuyuki 
Published: November 2015

AbstractMesoporous bimetallic Au–Pt with a phase‐segregated heterostructure has been prepared by using mesoporous silica SBA‐15 as a template. Au nanoparticles were prepared as a seed metal within the mesopores, and subsequently Pt was deposited, sandwiching the Au seeds. Energy‐dispersive X‐ray (EDX) spectral mapping showed that the framework of mesoporous bimetallic Au–Pt, prepared by removing the silica template with HF, was composed of Au nanoparticles joined with Pt nanowires. The Au/Pt ratio of the mesoporous bimetallic Au–Pt could be varied by controlling the number of Au deposition cycles. Pre‐adsorbed CO (COad) stripping voltammetry of the mesoporous bimetallic Au–Pt showed that the surfaces of the joined bimetallic structure were electrochemically active. This could be attributed to the open framework structure having a high ratio of exposed bimetallic mesopore surfaces. The described preparative approach, involving a mesoporous silica template and stepwise deposition within the mesopores, enables control of the nanostructure of the bimetallic material, which is greatly promising for the further development of synthetic methodologies for bimetallic structures.
A Post‐Synthetically Modified MOF for Selective and Sensitive Aqueous‐Phase Detection of Highly Toxic Cyanide Ions
Authors: Karmakar Avishek , Kumar Naveen , Samanta Partha , Desai Aamod V. , Ghosh Sujit K. 
Published: November 2015

AbstractSelective and sensitive detection of toxic cyanide (CN−) by a post‐synthetically altered metal–organic framework (MOF) has been achieved. A post‐synthetic modification was employed in the MOF to incorporate the specific recognition site with the CN− ion over all other anions, such as Cl−, Br−, and SCN−. The aqueous‐phase sensing and very low detection limit, the essential prerequisites for an effective sensory material, have been fulfilled by the MOF. Moreover, the present detection level meets the standard set by the World Health Organization (WHO) for the permissible limit of cyanide concentration in drinking water. The utilization of MOF‐based materials as the fluorometric probes for selective and sensitive detection of CN− ions has not been explored till now.
Facile Installation of 2‐Reverse Prenyl Functionality into Indoles by a Tandem N‐Alkylation–Aza‐Cope Rearrangement Reaction and Its Application in Synthesis
Authors: Chen Xiaobei , Fan Huaqiang , Zhang Shilei , Yu Chenguang , Wang Wei 
Published: November 2015

AbstractAn unprecedented tandem N‐alkylation–ionic aza‐Cope (or Claisen) rearrangement–hydrolysis reaction of readily available indolyl bromides with enamines is described. Due to the complicated nature of the two processes, an operationally simple N‐alkylation and subsequent microwave‐irradiated ionic aza‐Cope rearrangement–hydrolysis process has been uncovered. The tandem reaction serves as a powerful approach to the preparation of synthetically and biologically important, but challenging, 2‐reverse quaternary‐centered prenylated indoles with high efficiency. Notably, unusual nonaromatic 3‐methylene‐2,3‐dihydro‐1H‐indole architectures, instead of aromatic indoles, are produced. Furthermore, the aza‐Cope rearrangement reaction proceeds highly regioselectively to give the quaternary‐centered reverse prenyl functionality, which often produces a mixture of two regioisomers by reported methods. The synthetic value of the resulting nonaromatic 3‐methylene‐2,3‐dihydro‐1H‐indole architectures has been demonstrated as versatile building blocks in the efficient synthesis of structurally diverse 2‐reverse prenylated indoles, such as indolines, indole‐fused sultams and lactams, and the natural product bruceolline D.
Sequence‐Dependent Duplex Stabilization upon Formation of a Metal‐Mediated Base Pair
Authors: Scharf Philipp , Jash Biswarup , Kuriappan Jissy A. , Waller Mark P. , Müller Jens 
Published: November 2015

AbstractAn artificial nucleoside surrogate with 1H‐imidazo[4,5‐f][1,10]phenanthroline (P) acting as an aglycone has been introduced into DNA oligonucleotide duplexes. This nucleoside surrogate can act as a bidentate ligand, and so is useful in the context of metal‐mediated base pairs. Several duplexes involving a hetero base pair with an imidazole nucleoside have been investigated. The stability of DNA duplexes incorporating the respective AgI‐mediated base pairs strongly depends on the sequence context. Quantum mechanical/molecular mechanical (QM/MM) calculations have been performed in order to gain insight into the factors determining this sequence dependence. The results indicated that, in addition to the stabilizing effect that results from the formation of coordinative bonds, destabilizing effects may occur when the artificial base pair does not fit optimally into the surrounding B‐DNA duplex.
Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs
Authors: Nicolaou Kyriacos C. , Vourloumis Dionisios , Totokotsopoulos Sotirios , Papakyriakou Athanasios , Karsunky Holger , Fernando Hanan , Gavrilyuk Julia , Webb Damien , Stepan Antonia F. 
Published: November 2015

AbstractA convenient synthesis of imatinib, a potent inhibitor of ABL1 kinase and widely prescribed drug for the treatment of a variety of leukemias, was devised and applied to the construction of a series of novel imatinib analogues featuring a number of non‐aromatic structural motifs in place of the parent molecule's phenyl moiety. These analogues were subsequently evaluated for their biopharmaceutical properties (e.g., ABL1 kinase inhibitory activity, cytotoxicity). The bicyclo[1.1.1]pentane‐ and cubane‐containing analogues were found to possess higher themodynamic solubility, whereas cubane‐ and cyclohexyl‐containing analogues exhibited the highest inhibitory activity against ABL1 kinase and the most potent cytotoxicity values against cancer cell lines K562 and SUP‐B15. Molecular modeling was employed to rationalize the weak activity of the compounds against ABL1 kinase, and it is likely that the observed cytotoxicity of these agents arises through off‐target effects.
The efficacy of adjuvant therapy for pancreatic invasive intraductal papillary mucinous neoplasm (IPMN)
Authors: McMillan Matthew T. , Lewis Russell S. , Drebin Jeffrey A. , Teitelbaum Ursina R. , Lee Major K. , Roses Robert E. , Fraker Douglas L. , Vollmer Charles M. 
Published: November 2015

BACKGROUNDThe literature investigating pancreatic invasive intraductal papillary mucinous neoplasm (IPMN) has largely come from small institutional studies, preventing adequately powered comparisons of adjuvant therapy versus surgery alone (SA) within specific patient subgroups.METHODSPatients with resected, stage I through IV, invasive IPMN and conventional pancreatic ductal adenocarcinoma (PDAC) were identified in the National Cancer Data Base (1998‐2010). Cox modeling of patients with invasive IPMN was used to compare overall survival (OS) between patients who received adjuvant therapy and those who underwent SA. A second model was used to compare OS between patients with invasive IPMN and those with PDAC.RESULTSFor the 1220 patients with invasive IPMN, the median OS was 28.9 months; the 1‐year and 5‐year actuarial survival rates were 76% and 17%, respectively; and 47% received adjuvant therapy. Cox modeling associated SA with worse OS (hazard ratio, 1.36; 95% confidence interval, 1.17‐1.58; P = .00005) as well as American Joint Committee on Cancer (AJCC) TNM stage III/IV disease, positive lymph node status, positive margins, and poor tumor differentiation (all P ≤ .05). In addition, Cox modeling stratified by the following characteristics demonstrated improved OS with adjuvant therapy: AJCC TNM stage II or III/IV, positive lymph node status, positive margins, and poorly differentiated tumors. There was no survival advantage from adjuvant therapy for patients who had AJCC TNM stage I or lymph node‐negative disease. Patients who had invasive IPMN had improved risk‐adjusted OS compared with those who had PDAC (hazard ratio, 0.73; 95% confidence interval, 0.68‐0.78; P < .00001).CONCLUSIONSInvasive IPMN appears to be more indolent than conventional PDAC. Adjuvant therapy is associated with improved OS compared with SA in patients with invasive IPMN, especially for those with higher stage disease, positive lymph nodes, positive margins, or poorly differentiated tumors. Conversely, this benefit does not extend to patients with stage I or lymph node‐negative disease. Cancer 2016;122:521–533. © 2015 American Cancer Society.
Organization of the sleep‐related neural systems in the brain of the minke whale (Balaenoptera acutorostrata)
Authors: Dell Leigh‐Anne , Karlsson Karl Æ. , Patzke Nina , Spocter Muhammad A. , Siegel Jerome M. , Manger Paul R. 
Published: November 2015

ABSTRACTThe current study analyzed the nuclear organization of the neural systems related to the control and regulation of sleep and wake in the basal forebrain, diencephalon, midbrain, and pons of the minke whale, a mysticete cetacean. While odontocete cetaceans sleep in an unusual manner, with unihemispheric slow wave sleep (USWS) and suppressed REM sleep, it is unclear whether the mysticete whales show a similar sleep pattern. Previously, we detailed a range of features in the odontocete brain that appear to be related to odontocete‐type sleep, and here present our analysis of these features in the minke whale brain. All neural elements involved in sleep regulation and control found in bihemispheric sleeping mammals and the harbor porpoise were present in the minke whale, with no specific nuclei being absent, and no novel nuclei being present. This qualitative similarity relates to the cholinergic, noradrenergic, serotonergic and orexinergic systems, and the GABAergic elements of these nuclei. Quantitative analysis revealed that the numbers of pontine cholinergic (274,242) and noradrenergic (203,686) neurons, and hypothalamic orexinergic neurons (277,604), are markedly higher than other large‐brained bihemispheric sleeping mammals. Small telencephalic commissures (anterior, corpus callosum, and hippocampal), an enlarged posterior commissure, supernumerary pontine cholinergic and noradrenergic cells, and an enlarged peripheral division of the dorsal raphe nuclear complex of the minke whale, all indicate that the suite of neural characteristics thought to be involved in the control of USWS and the suppression of REM in the odontocete cetaceans are present in the minke whale. J. Comp. Neurol. 524:2018–2035, 2016. © 2015 Wiley Periodicals, Inc.
EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development
Authors: Son Alexander I. , Hashimoto‐Torii Kazue , Rakic Pasko , Levitt Pat , Torii Masaaki 
Published: November 2015

ABSTRACTDeciphering the molecular basis for guiding specific aspects of neocortical development remains a challenge because of the complexity of histogenic events and the vast array of protein interactions mediating these events. The Eph family of receptor tyrosine kinases is implicated in a number of neurodevelopmental activities. Eph receptors have been known to be capable of responding to several ephrin ligands within their subgroups, often eliciting similar downstream effects. However, several recent studies have indicated specificity between receptor–ligand pairs within each subfamily, the functional relevance of which is not defined. Here we show that a receptor of the EphA subfamily, EphA4, has effects distinct from those of its close relative, EphA7, in the developing brain. Both EphA4 and EphA7 interact similarly with corresponding ligands expressed in the developing neocortex. However, only EphA7 shows strong interaction with ligands in the somatosensory thalamic nuclei; EphA4 affects only cortical neuronal migration, with no visible effects on the guidance of corticothalamic (CT) axons, whereas EphA7 affects both cortical neuronal migration and CT axon guidance. Our data provide new evidence that Eph receptors in the same subfamily are not simply interchangeable but are functionally specified through selective interactions with distinct ligands in vivo. J. Comp. Neurol. 524:2080–2092, 2016. © 2015 Wiley Periodicals, Inc.
Differential distribution of the sodium‐activated potassium channels slick and slack in mouse brain
Authors: Rizzi Sandra , Knaus Hans‐Günther , Schwarzer Christoph 
Published: November 2015

ABSTRACTThe sodium‐activated potassium channels Slick (Slo2.1, KCNT2) and Slack (Slo2.2, KCNT1) are high‐conductance potassium channels of the Slo family. In neurons, Slick and Slack channels are involved in the generation of slow afterhyperpolarization, in the regulation of firing patterns, and in setting and stabilizing the resting membrane potential. The distribution and subcellular localization of Slick and Slack channels in the mouse brain have not yet been established in detail. The present study addresses this issue through in situ hybridization and immunohistochemistry. Both channels were widely distributed and exhibited distinct distribution patterns. However, in some brain regions, their expression overlapped. Intense Slick channel immunoreactivity was observed in processes, varicosities, and neuronal cell bodies of the olfactory bulb, granular zones of cortical regions, hippocampus, amygdala, lateral septal nuclei, certain hypothalamic and midbrain nuclei, and several regions of the brainstem. The Slack channel showed primarily a diffuse immunostaining pattern, and labeling of cell somata and processes was observed only occasionally. The highest Slack channel expression was detected in the olfactory bulb, lateral septal nuclei, basal ganglia, and distinct areas of the midbrain, brainstem, and cerebellar cortex. In addition, comparing our data obtained from mouse brain with a previously published study on rat brain revealed some differences in the expression and distribution of Slick and Slack channels in these species. J. Comp. Neurol. 524:2093–2116, 2016. © 2015 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.