bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of pharmacist medication interventions using medication regimen complexity
Authors: Zhao Bokai , Shen Ye , Devlin John W. , Murphy David J. , Smith Susan E. , Murray Brian , Rowe Sandra , Sikora Andrea 
Published: October 2024

AbstractBackgroundCritically ill patients are managed with complex medication regimens that require medication management to optimize safety and efficacy. When performed by a critical care pharmacist (CCP), discrete medication management activities are termed medication interventions. The ability to define CCP workflow and intervention timeliness depends on the ability to predict the medication management needs of individual intensive care unit (ICU) patients. The purpose of this study was to develop prediction models for the number and intensity of medication interventions in critically ill patients.MethodsThis was a retrospective, observational cohort study of adult patients admitted to an ICU between June 1, 2020 and June 7, 2023. Models to predict number of pharmacist interventions using both patient and medication related predictor variables collected at either baseline or in the first 24 hours of ICU stay were created. Both regression and supervised machine learning models (Random Forest, Support Vector Machine, XGBoost) were developed. Root mean square derivation (RMSE), mean absolute error (MAE), and symmetric mean absolute percentage error (sMAPE) were calculated.ResultsIn a cohort of 13,373 patients, the average number of interventions was 4.7 (standard deviation (SD) 7.1) and intervention intensity was 24.0 (40.3). Among the ML models, the Random Forest model had the lowest RMSE (9.26) while Support Vector Machine had the lowest MAE (4.71). All machine learning models performed similarly to the stepwise logistic regression model, and these performed better than a base model combining severity of illness with medication regimen complexity scores.ConclusionsIntervention quantity can be predicted using patient-specific factors. While inter-institutional variation in intervention documentation precludes external validation, our results provide a framework workload modeling at any institution.
Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke
Authors: Sato Yoshimichi , Li Yuandong , Kato Yuya , Kanoke Atsushi , Sun Jennifer Y , Nishijima Yasuo , Wang Ruikang K. , Stryker Michael , Endo Hidenori , Liu Jialing 
Published: October 2024

AbstractType 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke can also independently reduce flow velocity. However, the chronology and topological changes in collateral circulation in T2DM is not yet defined. Here, we describe the spatial and temporal blood flow dynamics and vessel remodeling in pial arteries and veins and leukocyte- endothelial adhesion following middle cerebral artery (MCA) stroke using two-photon microscopy in awake control and T2DM mice. Relative to control mice prior to stroke, T2DM mice already exhibited smaller pial vessels with reduced flow velocity. Following stroke, T2DM mice displayed persistently reduced blood flow in pial arteries and veins, resulting in a poor recovery of downstream penetrating arterial flow and a sustained deficit in microvascular flow. There was also persistent increase of leukocyte adhesion to the endothelium of veins, coincided with elevated neutrophils infiltration into brain parenchyma in T2DM mice compared to control mice after stroke. Our data suggest that T2DM-induced increase in chronic inflammation may contribute to the remodeling of leptomeningeal collateral circulation and the observed hemodynamics deficiency that potentiates poor stroke outcome.HighlightsBlood flow and leukocyte imaging in awake mice by two-photon microscopy before and after stroke under physiological conditionsT2DM induces collateral remodeling prior to strokeT2DM reduces blood flow and impedes recovery in pial arteries and veins after ischemic strokePoor recovery of penetrating arterial flow and sustained deficit in microvascular flow after ischemic stroke in T2DM miceT2DM increases persistent leukocyte adhesion to endothelium of veins and elevates neutrophils infiltration into the brain parenchyma after ischemic stroke.
The computational bottleneck of basal ganglia output (and what to do about it)
Authors: Humphries Mark D. 
Published: October 2024

AbstractWhat the basal ganglia do is an oft-asked question; answers range from the selection of actions to the specification of movement to the estimation of time. Here I argue thathowthe basal ganglia do what they do is a less-asked but equally important question. I show that the output regions of the basal ganglia create a stringent computational bottleneck, both structurally, because they have far fewer neurons than do their target regions, and dynamically, because of their tonic, inhibitory output. My proposed solution to this bottleneck is that the activity of an output neuron is setting the weight of a basis function, a function defined by that neuron’s synaptic contacts. I illustrate how this may work in practice, allowing basal ganglia output to shift cortical dynamics and control eye movements via the superior colliculus. This solution can account for troubling issues in our understanding of the basal ganglia: why we see output neurons increasing their activity during behaviour, rather than only decreasing as predicted by theories based on disinhibition, and why the output of the basal ganglia seems to have so many codes squashed into such a tiny region of the brain.Significance statementThe basal ganglia are implicated in an extraordinary range of functions, from action selection to timing, and dysfunctions, from Parkinson’s disease to obsessive compulsive disorder. Yet however the basal ganglia cause these functions and dysfunctions they must do so through a group of neurons that are dwarfed in number by both their inputs and their output targets. Here I lay out this bottleneck problem for basal ganglia computation, and propose a solution to how their outputs can control their many targets. That solution rethinks the output connections of the basal ganglia as a set of basis functions. In doing so, it provides explanations for previously troubling data on basal ganglia output, and strong predictions for how that output controls its targets.
Green upgrading of SPring-8 to produce stable, ultrabrilliant hard X-ray beams
Authors: Tanaka Hitoshi , Watanabe Takahiro , Abe Toshinori , Azumi Noriyoshi , Aoki Tsuyoshi , Dewa Hideki , Fujita Takahiro , Fukami Kenji , Fukui Toru , Hara Toru , Hiraiwa Toshihiko , Imamura Kei , Inagaki Takahiro , Iwai Eito , Kagamihata Akihiro , Kawase Morihiro , Kida Yuichiro , Kondo Chikara , Maesaka Hirokazu , Magome Tamotsu , Masaki Mitsuhiro , Masuda Takemasa , Matsubara Shinichi , Matsui Sakuo , Ohshima Takashi , Oishi Masaya , Seike Takamitsu , Shoji Masazumi , Soutome Kouichi , Sugimoto Takashi , Suzuki Shinji , Tajima Minori , Takano Shiro , Tamura Kazuhiro , Tanaka Takashi , Taniuchi Tsutomu , Taniuchi Yukiko , Togawa Kazuaki , Tomai Takato , Ueda Yosuke , Yamaguchi Hiroshi , Yabashi Makina , Ishikawa Tetsuya 
Published: October 2024

SPring-8-II is a major upgrade project of SPring-8 that was inaugurated in October 1997 as a third-generation synchrotron radiation light source. This upgrade project aims to achieve three goals simultaneously: achievement of excellent light source performance, refurbishment of aged systems, and significant reduction in power consumption for the entire facility. A small emittance of 50 pm rad will be achieved by (1) replacing the existing double-bend lattice structure with a five-bend achromat one, (2) lowering the stored beam energy from 8 to 6 GeV, (3) increasing the horizontal damping partition number from 1 to 1.3, and (4) enhancing horizontal radiation damping by installing damping wigglers in long straight sections. The use of short-period in-vacuum undulators allows ultrabrilliant X-rays to be provided while keeping a high-energy spectral range even at the reduced electron-beam energy of 6 GeV. To reduce power consumption, the dedicated, aged injector system has been shut down and the high-performance linear accelerator of SACLA, a compact X-ray free-electron laser (XFEL) facility, is used as the injector of the ring in a time-shared manner. This allows the simultaneous operation of XFEL experiments at SACLA and full/top-up injection of the electron beam into the ring. This paper overviews the concept of the SPring-8-II project, the system design of the light source and the details of the accelerator component design.
Can digital transformation promote the turnaround of declining firms? Empirical evidence from Chinese listed companies
Authors: Fang Xiaozhen , Yuan Fang 
Published: October 2024

PurposeDigital transformation provides a new impetus for the development of declining firms. However, there is currently a lack of sufficient research on whether digital transformation is beneficial for the turnaround of declining firms. This paper aims to explore the relationship between digital transformation and the turnaround of declining firms.Design/methodology/approachDrawing on the theoretical foundations of the resource-based view and dynamic capabilities theory, this research uses a comprehensive dataset of Chinese A-share listed companies from 2010–2021 to explore the influence of digital transformation on the turnaround of declining firms.FindingsThe research findings show that digital transformation contributes to the turnaround of declining firms. Mechanism analyses demonstrate that digital transformation enhances dynamic capabilities and attracts more analysts, thereby facilitating the turnaround process. Moreover, the moderation analysis reveals that CEO equity incentives strengthen the positive correlation between digital transformation and the turnaround of declining firms. Heterogeneity analysis indicates that the association between digital transformation and the turnaround of declining firms is particularly significant for firms with low financing constraints and high-tech firms. Moreover, this research reveals that digital transformation can facilitate the turnaround of firms in deep and long-term decline.Originality/valueThis research contributes to the literature on the digital transformation of enterprises and provides important insights for the turnaround of declining firms.
Effect of contractual functions on contractors’ consummate performance behaviors in construction projects
Authors: Lu Yongqiang , Ma Li , Yao Haona 
Published: October 2024

PurposeThe contractors’ consummate performance behavior is the key to achieving the project’s value added, but existing research has paid little attention to how to stimulate this behavior. Based on contractual functions and regulatory focus theory, this study examined how the allocation of contractual functions and the contractors’ regulatory focus affect their consummate performance behaviors. At the same time, considering the important position of guanxi between owner and contractor, this study also examined the moderating effect of guanxi on the relationship between the contractors’ regulatory focus and consummate performance behaviors.Design/methodology/approachThis study first constructs a conceptual model that incorporates contractual functions (control, coordination and adaptation), contractors’ regulatory focus (promotion focus, prevention focus) and the effect of guanxi on contractors’ consummate performance behavior. Next, partial least squares structural equation modeling is used to analyze the survey data of 297 Chinese construction project professionals.FindingsThis study has the following four findings. First, contractual control has a negative effect on contractors’ promotion focus but a positive effect on their prevention focus. Contractual coordination and adaptation have a positive effect on contractors’ promotion focus but a negative effect on their prevention focus. Second, contractors’ promotion focus has a positive effect on their consummate performance behaviors, while their prevention focus has a negative effect on such behaviors. Third, both of contractors’ promotion focus and prevention focus play a mediating role in the relationship between contractual functions and their consummate performance behaviors. Finally, guanxi plays a moderating role in the relationship between contractors’ regulatory focus and their consummate performance behaviors.Originality/valueTheoretically, this study enriches the research on the antecedents of contractors’ regulatory focus and extends the literature on contractual and guanxi management in construction projects. In practice, this study can provide guidance for improving contractors’ consummate performance behaviors and reasonable allocation of contractual functions.
Financing mode and scheme decision support for large urban rail transit projects: a revised case-based reasoning approach
Authors: Zheng Xian , Huang Yiling , Liu Yan , Zhang Zhong , Li Yongkui , Yan Hang 
Published: October 2024

PurposeAs the complex influencing factors for financing decisions and limited information at the early project stage often render inappropriate financing mode and scheme (FMS) selection in the large-scale urban rail transit (URT) field, this study aims to identify the multiple influencing factors and establish a revised case-based reasoning (CBR) model by drawing on experience in historical URT projects to provide support for effective FMS decisions.Design/methodology/approachOur research proposes a two-phase, five-step CBR model for FMS decisions. We first establish a case database containing 116 large-scale URT projects and a multi-attribute FMS indicator system. Meanwhile, grey relational analysis (GRA), the entropy-revised G1 method and the time decay function have been employed to precisely revise the simple CBR model for selecting high-similarity cases. Then, the revised CBR model is verified by nine large-scale URT projects and a demonstration project to prove its decision accuracy and effectiveness.FindingsWe construct a similarity case indicator system of large-scale URT projects with 11 indicators across three attributes, in which local government fiscal pressure is considered the most influential indicator for FMS decision-making. Through the verification with typical URT projects, the accuracy of our revised CBR model can reach 89%. The identified high-similarity cases have been confirmed to be effective for recommending appropriate financing schemes matched with a specific financing mode.Originality/valueThis is the first study employing the CBR model, an artificial intelligence approach that simulates human cognition by learning from similar past experiences and cases to enhance the accuracy and reliability of FMS decisions. Based on the characteristics of the URT projects, we revise the CBR model in the case retrieval process to achieve a higher accuracy. The revised CBR model utilizes expert experience and historical information to provide a valuable auxiliary tool for guiding the relevant government departments in making systematic decisions at the early project stage with limited and ambiguous project information.
Research on contractor claim strategy based on the principle of maximizing profits by using evolutionary game model
Authors: Huang Ying , Chen Ruixiong , Guo Pan , Duan Zhaocheng 
Published: October 2024

PurposeThis research uses the evolutionary game model theory to explore how to make decisions to maximize their own interests in the process of project claims from the perspective of small and medium-sized contractors in the construction industry.Design/methodology/approachThis study defines the discount factor in the claim process based on the characteristics of construction claims and provides a specific calculation method. The paper analyzes the matching degree between the evolutionary game model and the process of construction claims. Further, the discount factor is introduced to construct an evolutionary game model of engineering claims with the goal of maximizing the contractor’s benefits.FindingsThe results of this study show that in the situation (C*d1-nC1*d1>0, v2-v1-g>0) and (C*d1-nC1*d1>0, v2-v1-g<0), the contractor claim decision-making strategy is a truthful claim, while in the situation (C*d1-nC1*d1<0, v2-v1-g>0) and (C*d1-nC1*d1<0, v2-v1-g<0), the contractor claim decision-making strategy is a high-price claim. The discount factor will affect the decision-making rate. It is noted that the fines and the explicit costs received during the contractor’s high-priced claim process exhibit a positive correlation with the rate of truthful claim decision-making by contractors. Meanwhile, the final revenue of high-priced claims by contractors shows a positive correlation with the rate of high-priced claim decision-making by the sensitivity analysis.Research limitations/implicationsThe author simulates the process of solving the actual claim problem through the evolutionary game model in engineering claims. It is hoped that researchers will collect empirical cases and compare the actual case solutions with the model solutions to further revise the model in future studies, an evolutionary game model of engineering claim decision-making with interference factors can be constructed to analyze the evolutionary stability. Secondly, the single factor sensitivity analysis of individual parameters is carried out in this paper, and the influence of multiple factors on claim decisions can be further analyzed in the later research.Practical implicationsThe analysis of the claim process based on the evolutionary game model is conducive to the contractor’s rapid claim decision-making. The introduction of the discount factor to analyze the claim process is more conducive to the accuracy of the contractor’s claim decision.Originality/valueThe proposed model provides a supplement to the existing studies on dynamic construction claim decision-making. The claim decision is conducive to controling cost for the contractor, improving the contractor’s management level and developing a healthy construction market.
Anticipating emerging issues for resilient energy systems: wider, deeper and further perspectives
Authors: Önnered Simon , Sannö Anna , Stefan Ioana , Johansson Peter E. 
Published: October 2024

Purpose
The purpose of this study is to explore the long-term, deeper transformations occurring in the wider energy transition to anticipate emerging issues through collective anticipatory intelligence.

Design/methodology/approach
Through a co-productive research design, the authors collectively scanned and discussed contemporary developments in the Swedish energy transition. The acquired insight was used in a causal layered analysis over three horizons to separate between views and developments in time and space.

Findings
Findings of this study present current, transitionary and emerging issues and how they emerge from deeper levels such as values and worldviews. These issues are discussed around how underlying changes may change to mitigate them, suggesting three strategies.

Practical implications
The framed and anticipated issues enable monitoring and proactive response, and the discussion contributes insight to ongoing political debates, as well as implications for managing similar initiatives.

Social implications
Insights are provided into the changing cultures and values required in a future energy system, showing, e.g. how demand-side response may either come through relinquishing control over consumption or through increased flexibility and change.

Originality/value
Studying issues of growing concern and novel approaches, this paper should be of interest to practitioners in the energy sector and foresight professionals. It provides a critique and framing of issues to be monitored, adding to the growing library of energy futures studies.
Intercultural adaptability development for students in internationalisation at home programmes in higher education in China and Korea
Authors: Luong Phuong Minh , Tran Ly Thi , Nguyen Huyen Thanh , Tran Yen Thi Hai , Dang Giang Hoang , Vu Toan Van 
Published: October 2024

PurposeThis article reviews the intercultural adaptability (IA) development models for students in South Korea and China in response to the growing internationalisation of higher education. The article provides significant implications for Confucian heritage culture (CHC) countries and others that wish to enhance in higher education.Design/methodology/approachThis scoping review systematically investigates the literature on different IA development strategies for students in higher education across these two Asian countries.FindingsSouth Korea has promoted the self-growth model reflected in internationalised programmes such as English as a Medium of Instruction (EMI), an international learning environment with an increasing number of international students and student exchange programmes. Through these initiatives, domestic students’ identity and intercultural learning dynamics are enriched in an intercultural learning environment. Meanwhile, China has adopted the “Outward-oriented” higher education internationalisation model to attract international students to study in Chinese universities and entice Chinese returnees through its International Talent Training Programmes. In this strategy, international students are exposed to Chinese language and cultural knowledge development programmes, and Chinese students are motivated to learn the English language and cultures through interactions with their international peers.Originality/valueStudent IA development models in CHC countries remain underexplored. This article responds to the need of higher education institutions in Asian countries that wish to access and learn from effective IA models from other CHC countries. The study makes a valuable contribution by putting forward significant recommendations for developing students’ IA in CHC countries.
Socially responsible investments inside out: a new conceptual framework for investigating retail investor preferences
Authors: Pasquino Matteo , Lucarelli Caterina 
Published: October 2024

PurposeThe literature on the drivers affecting retail investor preferences towards socially responsible investments (SRIs) has increased significantly over recent years, revealing several influencing factors. Given the wide variety and ambiguity of the available evidence, the purpose of this paper is to analyse the existing literature on this topic and develop a new unified approach to study this phenomenon.Design/methodology/approachWe conducted a systematic literature review, followed by a research profile analysis and a thematic analysis, which uncovered four major emerging foci: the research outcome type, the external environment, sociodemographic characteristics and the internal dimension of retail investors.FindingsOur analysis revealed that studies investigating investor preferences often neglected to consider the concurring influence of multiple perspectives. In fact, we observed how the literature has not yet adequately addressed the mediating and moderating effects of the various factors that determine retail investor decisions regarding SRI.Research limitations/implicationsIn response to these shortfalls, we propose a new integrated conceptual framework that may inspire scholars to conduct further studies to refine our understanding of investor preferences towards SRI.Practical implicationsThis framework offers some suggestions on how to expand future research and underline some managerial and policy interventions aimed at developing the retail demand for these products.Originality/valueTo our knowledge, this is the first study to perform a systematic review on the drivers of SRIs, elaborating a new conceptual framework to understand the dynamics of retail investor sustainable preferences.