bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Search of Mobile Applications for Patients With Pelvic Floor Disorders
Authors: Sudol Neha T. , Adams-Piper Emily , Perry Rachel , Lane Felicia , Chen Katherine T. 
Published: December 2017

Objectives
The aims of the study were to identify patient-centered applications (apps) in female pelvic medicine and reconstructive surgery and to evaluate them using a modified APPLICATIONS scoring system.

Methods
A comprehensive list of female pelvic medicine and reconstructive surgery search terms was used to identify apps in the iTunes store. Apps that were eligible for scoring were in English, pertinent to the search term, patient centered, and accurate. All five authors independently evaluated eligible apps using a modified APPLICATIONS scoring system and subsequently reconciled differences by discussion.

Results
One hundred and fifty-seven terms were generated and searched in the iTunes Store to reveal 4127 apps. Twenty-three eligible apps were scored. Approximately half (47%, 11/23) of the apps were free. Twelve (52%) apps cited scientific literature or expert source. Only 8 (35%) of the apps were also available in the Google Play Store. “Squeezy,” “LeakFreeMe,” and “Stop UTI” received the highest score of 14.

Conclusions
Few identified apps were accurate and subsequently scored. Our results demonstrate that when searching for apps, patients are likely to obtain information that is not relevant or inaccurate, even if the appropriate search term is used. By carefully excluding inaccurate apps, providers should feel confident that the 23 scored apps can be shared with patients.
Shared genetic requirements for ATF5 translation in the vomeronasal organ and main olfactory epithelium
Authors: Dalton Ryan P 
Published: December 2017

AbstractBackgroundBoth olfactory sensory neurons (OSNs) and vomeronasal sensory neurons (VSNs) require the transcription factor Atf5 for maturation and survival. In OSNs, ATF5 translation is controlled by olfactory receptor (OR) expression-mediated activation of the PERK branch of the unfolded protein response. This study evaluated whether OSNs and VSNs share genetic requirements for ATF5 translation.MethodsATF5 immunoreactivity was assayed in whole vomeronasal organs from a series of genetic mutant animals identified in studies of OR gene choice, OR feedback, and regulation and OSN development.ResultsATF5 expression in VSNs required the histone demethylase Lsd1, which has been previously reported to be required for OR expression. ATF5 expression also required PERK-mediated phosphorylation of the translation initiation factor eIF2α. Finally, unlike previous observations in OSNs, ATF5 was found to be widespread in the mature VNO and co-expressed with mature VSN markers.ConclusionsThese data suggest that the initiation of ATF5 translation in VSNs and OSNs is under similar regulation, and that persistent/prolonged ATF5 translation in VSNs may serve VSN-specific gene regulatory programs. This study firmly establishes the unfolded protein response as a major controller of sensory neuronal maturation and diversification.
Effect sizes of somatic mutations in cancer
Authors: Cannataro Vincent L. , Gaffney Stephen G. , Townsend Jeffrey P. 
Published: December 2017

ABSTRACTA major goal of cancer biology is determination of the relative importance of the genomic alterations that confer selective advantage to cancer cells. Tumor sequence surveys have frequently ranked the importance of substitutions to cancer growth byPvalue or a false-discovery conversion thereof. However,Pvalues are thresholds for belief, not metrics of effect. Their frequent misuse as metrics of effect has often been vociferously decried. Here, we estimate the effect sizes of all recurrent single nucleotide variants in 23 cancer types, quantifying relative importance within and between driver genes. Some of the variants with the highest effect size, such as EGFR L858R in lung adenocarcinoma and BRAF V600E in primary skin cutaneous melanoma, have yielded remarkable therapeutic responses. Quantification of cancer effect sizes has immediate importance to the prioritization of clinical decision-making by tumor boards, selection and design of clinical trials, pharmacological targeting, and basic research prioritization.
Characterization of Gene Expression Changes Over Healthy Term Pregnancies
Authors: Knight Anna K. , Dunlop Anne L. , Kilaru Varun , Cobb Dawayland , Corwin Elizabeth J. , Conneely Karen N. , Smith Alicia K. 
Published: December 2017

AbstractDuring pregnancy, women experience numerous physiological changes but, to date, there is limited published data that characterize accompanying changes in gene expression over pregnancy. This study sought to characterize the complexity of gene expression over the course of pregnancy among women with healthy pregnancies. Subjects provided a venous blood sample during early (6-15 weeks) and late (22-33 weeks) pregnancy, which was used to isolate peripheral blood mononuclear cells prior to RNA extraction. Gene expression was examined for 63 women with uncomplicated, term deliveries. We evaluated the association between weeks gestation at sample collection and expression of each transcript. Of the 16,311 transcripts evaluated, 439 changed over pregnancy after a Bonferroni correction to account for multiple comparisons. Genes whose expression changed over pregnancy were associated with oxygen transport, the immune system, and host response to bacteria. Characterization of changes in gene expression over the course of healthy term pregnancies may enable the identification of genes whose expression predicts complications or adverse outcomes of pregnancy.
Evidence against the detectability of a hippocampal place code using functional magnetic resonance imaging
Authors: Nolan Christopher R. , Vromen J.M.G. , Cheung Allen , Baumann Oliver 
Published: December 2017

AbstractIndividual hippocampal neurons selectively increase their firing rates in specific spatial locations. As a population these neurons provide a decodable representation of space that is robust against changes to sensory- and path-related cues. This neural code is sparse and distributed, theoretically rendering it undetectable with population recording methods such as functional magnetic resonance imaging (fMRI). Existing studies nonetheless report decoding spatial codes in the human hippocampus using such techniques. Here we present results from a virtual navigation experiment in humans in which we eliminated visual- and path-related confounds and statistical shortcomings present in existing studies, ensuring that any positive decoding results would be only spatial in nature and would represent a true voxel-place code. Consistent with theoretical arguments derived from electrophysiological data and contrary to existing fMRI studies, our results show that although participants were fully oriented during the navigation task, there was no statistical evidence for a place code.
Transcriptomic analysis of longitudinalBurkholderia pseudomalleiinfecting the cystic fibrosis lung
Authors: Price Erin P. , Viberg Linda T. , Kidd Timothy J. , Bell Scott C. , Currie Bart J. , Sarovich Derek S. 
Published: December 2017

ABSTRACTThe melioidosis bacterium,Burkholderia pseudomallei, is increasingly being recognized as a pathogen in patients with cystic fibrosis (CF). We have recently catalogued genome-wide variation of paired, isogenicB. pseudomalleiisolates from seven Australasian CF cases, which were collected between four and 55 months apart. Here, we extend this investigation by documenting the transcriptomic changes inB. pseudomalleiin five cases. Following growth in an artificial CF sputum medium, four of the five paired isolates exhibited significant differential gene expression (DE) that affected between 32 and 792 genes. The greatest number of DE events was observed between patient CF9 strains, consistent with the hypermutator status of the latter strain, which is deficient in the DNA mismatch repair protein MutS. Two patient isolates harbored duplications that concomitantly increased expression of the β-lactamase genepenA, and a 35kb deletion in another abolished expression of 29 genes. Convergent expression profiles in the chronically-adapted isolates identified two significantly downregulated and 17 significantly upregulated loci, including the antibiotic resistance-nodulation-division (RND) efflux pump BpeEF-OprC, the quorum-sensinghhqABCDEoperon, and a cyanide- and pyocyanin-insensitive cytochromebdquinol oxidase. These convergent pathoadaptations lead to increased expression of pathways that may suppress competing bacterial and fungal pathogens and that enhance survival in oxygen-restricted environments, the latter of which may render conventional antibiotics less effectivein vivo. Treating chronically-adaptedB. pseudomalleiinfections with antibiotics designed to target anaerobic infections, such as the nitroimidazole class of antibiotics, may significantly improve pathogen eradication attempts by exploiting this Achilles heel.
An orthogonal and pH-tunable sensor-selector for muconic acid biosynthesis in yeast
Authors: Snoek Tim , Romero-Suarez David , Zhang Jie , Skjoedt Mette L. , Sudarsan Suresh , Jensen Michael K. , Keasling Jay D. 
Published: December 2017

AbstractMicrobes offer enormous potential for production of industrially relevant chemicals and therapeutics, yet the rapid identification of high-producing microbes from large genetic libraries is a major bottleneck in modern cell factory development. Here, we develop and apply a synthetic selection system in Saccharomyces cerevisiae that couples the concentration of muconic acid, a plastic precursor, to cell fitness by using the prokaryotic transcriptional regulator BenM driving an antibiotic resistance gene. We show the sensor-selector does not affect production, and find that tuning pH of the cultivation medium limits the rise of non-producing cheaters. We apply the sensor-selector to selectively enrich for best-producing variants out of a large library of muconic acid production strains, and identify an isolate that produced more than 2 g/L muconic acid in a bioreactor. We expect that this sensor-selector can aid the development of other synthetic selection systems based on allosteric transcription factors.
The rust fungus Melampsora larici-populina expresses a conserved genetic program and distinct sets of secreted protein genes during infection of its two host plants, larch and poplar
Authors: Lorrain Cécile , Marchal Clémence , Hacquard Stéphane , Delaruelle Christine , Pétrowski Jérémy , Petre Benjamin , Hecker Arnaud , Frey Pascal , Duplessis Sébastien 
Published: December 2017

SummaryMechanims required for broad spectrum or specific host colonization of plant parasites are poorly understood. As a perfect illustration, heteroecious rust fungi require two alternate host plants to complete their life cycle. Melampsora larici-populina infects two taxonomically unrelated plants, larch on which sexual reproduction is achieved and poplar on which clonal multiplication occurs leading to severe epidemics in plantations. High-depth RNA sequencing was applied to three key developmental stages of M. larici-populina infection on larch: basidia, pycnia and aecia. Comparative transcriptomics of infection on poplar and larch hosts was performed using available expression data. Secreted protein was the only significantly over-represented category among differentially expressed M. larici-populina genes in basidia, pycnia and aecia compared together, highlighting their probable involvement in the infection process. Comparison of fungal transcriptomes in larch and poplar revealed a majority of rust genes commonly expressed on the two hosts and a fraction exhibiting a host-specific expression. More particularly, gene families encoding small secreted proteins presented striking expression profiles that highlight probable candidate effectors specialized on each host. Our results bring valuable new information about the biological cycle of rust fungi and identify genes that may contribute to host specificity.
Synthesis, crystal structure and magnetic properties of diaquabis(2,6-diamino-7H-purin-1-ium-κN9)bis(4,4′-oxydibenzoato-κO)cobalt(II) dihydrate
Authors: Atria Ana María , Parada José , Moreno Yanko , Suárez Sebastián , Baggio Ricardo , Peña Octavio 
Published: December 2017

The title mononuclear CoIIcomplex, [Co(C5H7N6)2(C14H8O5)2(H2O)2]·2H2O, has been synthesized and its crystal structure determined by X-ray diffraction. The complex crystallizes in the triclinic space groupP\overline{1}, with one formula unit per cell (Z= 1 andZ′ = 1 \over 2). It consists of a mononuclear unit with the CoIIion on an inversion centre coordinated by two 2,6-diamino-7H-purin-1-ium cations, two 4,4′-oxydibenzoate anions (in a nonbridging κO-monodentate coordination mode, which is less common for the anion in its CoIIcomplexes) and two water molecules, defining an octahedral environment around the metal atom. There is a rich assortment of nonbonding interactions, among which a strong N+—H...O−bridge, with a short N...O distance of 2.5272 (18) Å, stands out, with the H atom ostensibly displaced away from its expected position at the donor side, towards the acceptor. The complex molecules assemble into a three-dimensional hydrogen-bonded network. A variable-temperature magnetic study between 2 and 300 K reveals an orbital contribution to the magnetic moment and a weak antiferromagnetic interaction between CoIIcentres as the temperature decreases. The model leads to the following values:A(crystal field strength) = 1.81, λ (spin-orbit coupling) = −59.9 cm−1,g(Landé factor) = 2.58 andzJ(exchange coupling) = −0.5 cm−1.
Achieving the United Nations Sustainable Development Goals
Authors: Bebbington Jan , Unerman Jeffrey 
Published: December 2017

PurposeThe purpose of this paper is to establish and advance the role of academic accounting in the pursuit of the United Nations Sustainable Development Goals (SDGs), which are regarded as the most salient point of departure for understanding and achieving environmental and human development ambitions up to (and no doubt beyond) the year 2030.Design/methodology/approachThis paper provides a synthesis of interdisciplinary perspectives on sustainable development and integration of this with the accounting for sustainability literature. In addition, potential accounting research contributions are proposed so as to support the development of new research avenues.FindingsExisting research in accounting that is relevant to individual SDGs serves as an initial link between them and the accounting discipline. At the same time, the SDGs focus highlights new sites for empirical work (including interdisciplinary investigations) as well as inviting innovation in accounting theoretical frameworks. Moreover, the SDGs provide a context for (re)invigorating accounting’s contribution to sustainable development debates.Originality/valueThis is the first paper to explore the roles academic accounting can play in furthering achievement of the SDGs through enhanced understanding, critiquing and advancing of accounting policy, practice and theorizing. It is also the first paper to propose a research agenda in this area.
Accrual management as an indication of money laundering through legally registered Mafia firms in Italy
Authors: Ravenda Diego , Valencia-Silva Maika M. , Argiles-Bosch Josep Maria , Garcia-Blandon Josep 
Published: December 2017

Purpose
The purpose of this paper is to investigate how accounting is used to disguise and carry out money laundering activities in specific socio-economic and political contexts and whether discretionary accruals can provide evidence of such illicit practices performed through legally registered Mafia firms (LMFs).

Design/methodology/approach
The study is based on a sample of 224 Italian firms identified as LMFs, due to having been confiscated by judicial authorities because of their owners being accused of Mafia-type association. Using a multivariate regression model, specifically developed discretionary accrual proxies for LMFs are compared with those of a population of lawful firms (LWFs).

Findings
The results reveal that in the pre-confiscation years, LMFs manage aggregate, revenue and expense accruals more than LWFs do, in order to smooth earnings and disguise/carry out money laundering. In contrast, in the post-confiscation years, there is no significant difference in the level of accrual management between LMFs and LWFs, as a consequence of the effective intervention of legal administrators.

Originality/value
This study adopts discretionary revenue and expense accrual proxies that provide additional insight into the simultaneous manipulation of revenues and expenses, linked to money laundering, which may not be fully detected by traditional aggregate accrual models. Furthermore, it suggests that the incentive for LMFs to manage accruals may be fostered by the irrelevance of their financial statements to trades with stakeholders. Finally, this paper may provide regulators with financial accounting signals which could be included in risk assessment models aiming to detect money laundering activities within firms.
Differentiated time management skills between leadership styles: simplified with a cross-cultural approach
Authors: Sarfraz Haniya 
Published: December 2017

Purpose
A common conception is that transformational, transactional, and other types of leaders implement similar time management skills; however, this paper aims to state that this is not true to a very large extent.

Design/methodology/approach
The characteristics of transactional, transformational, and other leadership styles are defined, while the popular and latest time management principles are incorporated with this description. There are eight time management categories, and this paper connects the respective categories to nine leadership styles based on each style’s nature. Cross-cultural leadership’s approach to time management is used to highlight and provide simplification for this process. Together, this showcases the importance and need to further investigate the relationship between leadership style, time management, and time conception.

Findings
This time management differentiation between transformational, transactional, and other leaders needs to be acknowledged, as this will deliver insight about how leaders can advance their leadership style. This differentiation brings greater understanding of the link between leadership and time management thus giving leaders deeper awareness on how they form their groundbreaking strategies and, with the cross-cultural leadership’s time management approach, mold their personal traits and experiences in coordination with this link.

Originality/value
This review states and highlights the difference in time management skills between nine leadership styles. The cross-cultural leadership approach helps identify three time and behavioral conceptions and the countries to which these conceptions are prominent in. The time conceptions assist leaders in understanding why they portray certain time management behaviors based on their cultural background, thus providing simplification in applying the time management skills for their leadership style.
Understanding barriers and enablers to training in humanitarian organizations: a SAP-LAP framework
Authors: Kabra Gaurav 
Published: December 2017

Purpose
This study aims to outline a practice-based theoretical model to identify barriers and enablers to training in humanitarian organizations toward improving the efficiency of humanitarian organizations.

Design/methodology/approach
The situation actor process-learning action performance (SAP-LAP) model has been applied to understand the barriers and enablers to training in humanitarian organizations. The synthesis of SAP leads to LAP, which helps in identifying bottlenecks of training through analysis of present situations and processes. Then, suggested courses of action for enhancing performance are laid down. The data have been collected through discussions with five practitioners involved in past relief operations in India.

Findings
In all, five barriers and six enablers were uncovered during discussions with practitioners illustrating the complexity involved in training in humanitarian organizations. The results suggest the need for more effective strategic planning much before actual training starts, particularly in the current situation where resources are limited in terms of time, capital and manpower.

Research limitations/implications
The SAP-LAP model needs further validation through empirical data.

Practical implications
This study contributes to existing body of literature and helps practitioners by providing a better understanding of barriers and enablers to training in humanitarian organizations.

Originality/value
This study is the first of its kind that integrates the views of practitioners in identifying barriers and enablers to training in humanitarian organizations toward improving the efficiency of humanitarian organizations.
A framework for untapped creativity: leveraging components of individual creativity for organizational innovation
Authors: Budhiraja Sunil , Pathak Ujjwal Kumar , Kaushik Neeraj 
Published: December 2017

PurposeThe purpose of this paper is to examine the components of individual creativity which are commonly unrecognized and untapped by managers and organizations. A framework is suggested to leverage these components of creativity for organizational innovation through organizational learning and support.Design/methodology/approachThis paper makes use of grounded theory based on three levels of feedback received from employees of six information technology (IT) companies in India. The paper makes use of qualitative responses (and narratives) received from software engineers, their respective project managers, and HR representatives on various components of individual creativity. Deliberation on the role of respective organizations is also included to tap and leverage the unrecognized components of creativityFindingsThe paper provides a framework for practitioners working in IT industries on how to leverage the untapped individual creativity to achieve greater process innovation.Research limitations/implicationsThis paper is written from the perspective of the Indian IT industry.Practical implicationsThe framework proposed in the study will help organizations to identify and use components to achieve organizational innovation.Originality/valueIn the context of the Indian IT industry, there has been little effort put into identifying and examining the untapped components of individual creativity to build sustainable innovative organizations. Moreover, the findings of the study will help IT companies to build robust models by using various learning interventions.