bluuebunny/crossref_metadata_2025_split huggingface dataset:
The US–China Naval Balance in the Asia-Pacific: An Overview
Authors: Goldstein Lyle 
Published: November 2017

AbstractA truism in strategic studies holds that warfare is highly complex and unpredictable. What appears to be a stable and predictable military balance can be suddenly overthrown by innovative doctrines or cunning strategies. This paper attempts to fill a perceived gap in strategic studies analysis with respect to US–China naval conflict scenarios. The author is concerned that most Western analyses on the subject tend to be simplistic and unduly optimistic. The approach in this paper follows a “Chinese style” in that it examines the Asia-Pacific strategic balance as a series of interacting military campaigns. The results of the analysis yield that the US retains a strong advantage in certain warfare domains, to be sure. Yet, the assumption that the US military has a decisive advantage in the relevant scenarios becomes dubious in light of the potentially devastating blow against US and allied bases that could be made by PLA conventional missile forces. Moreover, a Chinese advantage in the use of offensive mine warfare, when combined with China's ability to prevent US and allied aerial anti-submarine forces from flying, could combine to roll back, or at least significantly limit, Washington's heretofore decisive undersea advantage.
Landscape correlates of bushmeat consumption and hunting in a post-frontier Amazonian region
Authors: CARIGNANO TORRES PATRICIA , MORSELLO CARLA , PARRY LUKE , BARLOW JOS , FERREIRA JOICE , GARDNER TOBY , PARDINI RENATA 
Published: November 2017

SUMMARYIdentifying the drivers of bushmeat consumption and hunting is important for informing conservation strategies and recognizing challenges to human food security. However, studies often neglect the importance of landscape context, which can influence bushmeat supply and demand. Here, by quantifying bushmeat consumption and hunting in 262 households in a post-frontier region in Amazonia, we tested the hypotheses that bushmeat consumption and hunting are positively associated with two landscape characteristics: (1) forest cover, which has been shown to define game availability; and (2) remoteness, which is related to limited access to marketed meat. Bushmeat consumption was widespread but more likely in remote forested areas. Hunting was more likely in more forested areas, especially nearer to urban centres. Our findings suggest that bushmeat remains an important food source even in heavily altered forest regions and that landscape context is an important determinant of bushmeat consumption and hunting. Although people living in remote, forested areas are likely to be the most dependent on bushmeat, those living in more populous, peri-urban areas are likely the actors contributing most to total hunting effort, due to a higher probability of hunting combined with higher human population densities. This finding undermines the assumption that rural–urban migration in the tropics will deliver a much-needed reprieve for many overhunted species.
Field-Dependent Measurement of GaAs Composition by Atom Probe Tomography
Authors: Di Russo Enrico , Blum Ivan , Houard Jonathan , Da Costa Gérald , Blavette Didier , Rigutti Lorenzo 
Published: November 2017

AbstractThe composition of GaAs measured by laser-assisted atom probe tomography may be inaccurate depending on the experimental conditions. In this work, we assess the role of the DC field and the impinging laser energy on such compositional bias. The DC field is found to have a major influence, while the laser energy has a weaker one within the range of parameters explored. The atomic fraction of Ga may vary from 0.55 at low-field conditions to 0.35 at high field. These results have been interpreted in terms of preferential evaporation of Ga at high field. The deficit of As is most likely explained by the formation of neutral As complexes either by direct ejection from the tip surface or upon the dissociation of large clusters. The study of multiple detection events supports this interpretation.
Historical and contemporary aspects of maternal immunity in swine
Authors: Poonsuk Korakrit , Zimmerman Jeff 
Published: November 2017

AbstractMaternal immunity plays a pivotal role in swine health and production because piglets are born agammaglobulinemic and with limited cell-mediated immunity, i.e. few peripheral lymphoid cells, immature lymphoid tissues, and no effector and memory T-lymphocytes. Swine do not become fully immunologically competent until about 4 weeks of age, which means that their compromised ability to respond to infectious agents during the first month of life must be supplemented by maternal immune components: (1) circulating antibodies derived from colostrum; (2) mucosal antibodies from colostrum and milk; and (3) immune cells provided in mammary secretions. Because maternal immunity is highly effective at protecting piglets against specific pathogens, strengthening sow herd immunity against certain diseases through exposure or vaccination is a useful management tool for ameliorating clinical effects in piglets and delaying infection until the piglets’ immune system is better prepared to respond. In this review, we discuss the anatomy and physiology of lactation, the immune functions of components provided to neonatal swine in mammary secretion, the importance of maternal immunity in the prevention and control of significant pathogens.
Atomic-level molybdenum oxide nanorings with full-spectrum absorption and photoresponsive properties
Authors: Yang Yong , Yang Yang , Chen Shuangming , Lu Qichen , Song Li , Wei Yen , Wang Xun 
Published: November 2017

AbstractSuperthin nanostructures, particularly with atomic-level thicknesses, typically display unique optical properties because of their exceptional light–matter interactions. Here, we report a facile strategy for the synthesis of sulfur-doped molybdenum oxide nanorings with an atomic-level size (thickness of 0.5 nm) and a tunable ring-in-ring architecture. These atomic-level nanorings displayed strong photo-absorption in both the visible and infrared-light ranges and acted as a photothermal agent. Under irradiation with an 808 nm laser with an intensity of 1 W/cm2, a composite of the nanorings embedded in polydimethylsiloxane showed an ultrafast photothermal effect, delivering a local temperature of up to 400 °C within 20 s, which to the best of our knowledge is the highest temperature by light irradiation reported to date. Meanwhile, the resulting nanorings were also employed as a photoinitiator to remotely induce a visible-light shape memory response, self-healing, reshaping performance and reversible actuation of dynamic three-dimensional structures. This study demonstrates an advancement towards controlling atomic-level-sized nanostructures and achieving greatly enhanced optical performances for optoelectronics.
Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
Authors: Newman Alice C. , Kemp Alain J. , Drabsch Yvette , Behrends Christian , Wilkinson Simon 
Published: November 2017

AbstractMacroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mechanisms. We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A549 cells in vitro, yet promotes tumorigenesis in mice. ATG5 represses transcriptional activation by the TGFβ-SMAD gene regulatory pathway. However, autophagy does not terminate cytosolic signal transduction by TGFβ. Instead, we use proteomics to identify selective degradation of the signalling scaffold TRAF3. TRAF3 autophagy is driven by RAS and results in activation of the NF-κB family member RELB. We show that RELB represses TGFβ target promoters independently of DNA binding at NF-κB recognition sequences, instead binding with SMAD family member(s) at SMAD-response elements. Thus, autophagy antagonises TGFβ gene expression. Finally, autophagy-deficient A549 cells regain tumorigenicity upon SMAD4 knockdown. Thus, at least in this setting, a physiologic function for autophagic regulation of gene expression is tumour growth.
Polymer mimics of biomacromolecular antifreezes
Authors: Biggs Caroline I. , Bailey Trisha L. , Ben Graham  , Stubbs Christopher , Fayter Alice , Gibson Matthew I. 
Published: November 2017

AbstractAntifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced.
The genomic landscape of pediatric myelodysplastic syndromes
Authors: Schwartz Jason R. , Ma Jing , Lamprecht Tamara , Walsh Michael , Wang Shuoguo , Bryant Victoria , Song Guangchun , Wu Gang , Easton John , Kesserwan Chimene , Nichols Kim E. , Mullighan Charles G. , Ribeiro Raul C. , Klco Jeffery M. 
Published: November 2017

AbstractMyelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients. Our data show that, in contrast to adult MDS, Ras/MAPK pathway mutations are common in pediatric MDS (45% of primary cohort), while mutations in RNA splicing genes are rare (2% of primary cohort). Surprisingly, germline variants in SAMD9 or SAMD9L were present in 17% of primary MDS patients, and these variants were routinely lost in the tumor cells by chromosomal deletions (e.g., monosomy 7) or copy number neutral loss of heterozygosity (CN-LOH). Our data confirm that adult and pediatric MDS are separate diseases with disparate mechanisms, and that SAMD9/SAMD9L mutations represent a new class of MDS predisposition.
Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
Authors: Prakash Prem , Zeeshan Mohammad , Saini Ekta , Muneer Azhar , Khurana Sachin , Kumar Chourasia Bishwanath , Deshmukh Arunaditya , Kaur Inderjeet , Dabral Surabhi , Singh Niharika , Anam Zille , Chaurasiya Ayushi , Kaushik Shikha , Dahiya Pradeep , Kalamuddin Md. , Kumar Thakur Jitendra , Mohmmed Asif , Ranganathan Anand , Malhotra Pawan 
Published: November 2017

AbstractInvasion of human erythrocytes by Plasmodium falciparum merozoites involves multiple interactions between host receptors and their merozoite ligands. Here we report human Cyclophilin B as a receptor for PfRhopH3 during merozoite invasion. Localization and binding studies show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. We demonstrate that PfRhopH3 binds to the RBCs and their treatment with Cyclosporin A prevents merozoite invasion. We also show a multi-protein complex involving Cyclophilin B and Basigin, as well as PfRhopH3 and PfRh5 that aids the invasion. Furthermore, we report identification of a de novo peptide CDP3 that binds Cyclophilin B and blocks invasion by up to 80%. Collectively, our data provide evidence of compounded interactions between host receptors and merozoite surface proteins and paves the way for developing peptide and small-molecules that inhibit the protein−protein interactions, individually or in toto, leading to abrogation of the invasion process.
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Authors: Carreras-Puigvert Jordi , Zitnik Marinka , Jemth Ann-Sofie , Carter Megan , Unterlass Judith E. , Hallström Björn , Loseva Olga , Karem Zhir , Calderón-Montaño José Manuel , Lindskog Cecilia , Edqvist Per-Henrik , Matuszewski Damian J. , Ait Blal Hammou , Berntsson Ronnie P. A. , Häggblad Maria , Martens Ulf , Studham Matthew , Lundgren Bo , Wählby Carolina , Sonnhammer Erik L. L. , Lundberg Emma , Stenmark Pål , Zupan Blaz , Helleday Thomas 
Published: November 2017

AbstractThe NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their biological roles and biochemical redundancies remain largely unclear. To address this, we globally resolve their individual properties and inter-relationships. We purify 18 of the human NUDIX proteins and screen 52 substrates, providing a substrate redundancy map. Using crystal structures, we generate sequence alignment analyses revealing four major structural classes. To a certain extent, their substrate preference redundancies correlate with structural classes, thus linking structure and activity relationships. To elucidate interdependence among the NUDIX hydrolases, we pairwise deplete them generating an epistatic interaction map, evaluate cell cycle perturbations upon knockdown in normal and cancer cells, and analyse their protein and mRNA expression in normal and cancer tissues. Using a novel FUSION algorithm, we integrate all data creating a comprehensive NUDIX enzyme profile map, which will prove fundamental to understanding their biological functionality.
Possible nematic to smectic phase transition in a two-dimensional electron gas at half-filling
Authors: Qian Q. , Nakamura J. , Fallahi S. , Gardner G. C. , Manfra M. J. 
Published: November 2017

AbstractLiquid crystalline phases of matter permeate nature and technology, with examples ranging from cell membranes to liquid-crystal displays. Remarkably, electronic liquid-crystal phases can exist in two-dimensional electron systems (2DES) at half Landau-level filling in the quantum Hall regime. Theory has predicted the existence of a liquid-crystal smectic phase that breaks both rotational and translational symmetries. However, previous experiments in 2DES are most consistent with an anisotropic nematic phase breaking only rotational symmetry. Here we report three transport phenomena at half-filling in ultra-low disorder 2DES: a non-monotonic temperature dependence of the sample resistance, dramatic onset of large time-dependent resistance fluctuations, and a sharp feature in the differential resistance suggestive of depinning. These data suggest that a sequence of symmetry-breaking phase transitions occurs as temperature is lowered: first a transition from an isotropic liquid to a nematic phase and finally to a liquid-crystal smectic phase.
Graphene balls for lithium rechargeable batteries with fast charging and high volumetric energy densities
Authors: Son In Hyuk , Park Jong Hwan , Park Seongyong , Park Kwangjin , Han Sangil , Shin Jaeho , Doo Seok-Gwang , Hwang Yunil , Chang Hyuk , Choi Jang Wook 
Published: November 2017

AbstractImproving one property without sacrificing others is challenging for lithium-ion batteries due to the trade-off nature among key parameters. Here we report a chemical vapor deposition process to grow a graphene–silica assembly, called a graphene ball. Its hierarchical three-dimensional structure with the silicon oxide nanoparticle center allows even 1 wt% graphene ball to be uniformly coated onto a nickel-rich layered cathode via scalable Nobilta milling. The graphene-ball coating improves cycle life and fast charging capability by suppressing detrimental side reactions and providing efficient conductive pathways. The graphene ball itself also serves as an anode material with a high specific capacity of 716.2 mAh g−1. A full-cell incorporating graphene balls increases the volumetric energy density by 27.6% compared to a control cell without graphene balls, showing the possibility of achieving 800 Wh L−1 in a commercial cell setting, along with a high cyclability of 78.6% capacity retention after 500 cycles at 5C and 60 °C.
QTL mapping and molecular characterization of the classical D locus controlling seed and flower color in Linum usitatissimum (flax)
Authors: Sudarshan Gurudatt Pavagada , Kulkarni Manoj , Akhov Leonid , Ashe Paula , Shaterian Hamid , Cloutier Sylvie , Rowland Gordon , Wei Yangdou , Selvaraj Gopalan 
Published: November 2017

AbstractThe flowers of flax (linseed) are blue-hued, ephemeral and self-pollinating, and the seeds are typically brown. A century-old interest in natural yellow seed variants and a historical model point to recessive alleles in B1, D and G loci being responsible, but the functional aspects had remained unknown. Here, we characterized the “D” locus by quantitative trait loci (QTL) mapping and identified a FLAVONOID 3′5′ HYDROXYLASE (F3′5′H) gene therein. It does not belong to the F3′5′H clade, but resembles biochemically characterized F3′Hs (flavonoid 3′ hydroxylase) but without F3′H activity. The genome lacks other F3′H or F3′H-like genes. The apparent neo-functionalization from F3′H is associated with a Thr498 → Ser498 substitution in a substrate recognition site (SRS). The yellow seed and white flower phenotypes of the classical d mutation was found to be due to one nucleotide deletion that would truncate the deduced product and remove three of the six potential SRS, negatively impacting delphinidin synthesis. Delphinidin is sporadic in angiosperms, and flax has no known pollination syndrome(s) with functional pollinator group(s) that are attracted to blue flowers, raising questions on the acquisition of F3′5′H. The appearance of d allele is suggestive of the beginning of the loss of F3′5′H in this species.
Gpufit: An open-source toolkit for GPU-accelerated curve fitting
Authors: Przybylski Adrian , Thiel Björn , Keller-Findeisen Jan , Stock Bernd , Bates Mark 
Published: November 2017

AbstractWe present a general purpose, open-source software library for estimation of non-linear parameters by the Levenberg-Marquardt algorithm. The software, Gpufit, runs on a Graphics Processing Unit (GPU) and executes computations in parallel, resulting in a significant gain in performance. We measured a speed increase of up to 42 times when comparing Gpufit with an identical CPU-based algorithm, with no loss of precision or accuracy. Gpufit is designed such that it is easily incorporated into existing applications or adapted for new ones. Multiple software interfaces, including to C, Python, and Matlab, ensure that Gpufit is accessible from most programming environments. The full source code is published as an open source software repository, making its function transparent to the user and facilitating future improvements and extensions. As a demonstration, we used Gpufit to accelerate an existing scientific image analysis package, yielding significantly improved processing times for super-resolution fluorescence microscopy datasets.
A new method to measure mechanics and dynamic assembly of branched actin networks
Authors: Bauër Pierre , Tavacoli Joseph , Pujol Thomas , Planade Jessica , Heuvingh Julien , du Roure Olivia 
Published: November 2017

AbstractWe measured mechanical properties and dynamic assembly of actin networks with a new method based on magnetic microscopic cylinders. Dense actin networks are grown from the cylinders’ surfaces using the biochemical Arp2/3-machinery at play in the lamellipodium extension and other force-generating processes in the cell. Under a homogenous magnetic field the magnetic cylinders self-assemble into chains in which forces are attractive and depend on the intensity of the magnetic field. We show that these forces, from piconewtons to nanonewtons, are large enough to slow down the assembly of dense actin networks and controlled enough to access to their non linear mechanical responses. Deformations are measured with nanometer-resolution, well below the optical resolution. Self-assembly of the magnetic particles into chains simplifies experiments and allows for parallel measurements. The combination of accuracy and good throughput of measurements results in a method with high potential for cell and cytoskeleton mechanics. Using this method, we observed in particular a strong non linear mechanical behavior of dense branched actin networks at low forces that has not been reported previously.
Plastic deformation behaviour of single-crystalline martensite of Ti-Nb shape memory alloy
Authors: Tahara Masaki , Okano Nao , Inamura Tomonari , Hosoda Hideki 
Published: November 2017

Abstractβ-Ti alloys have attracted considerable attention as new biomedical shape memory alloys. Given the critical importance of the plastic deformation in the martensite phase for the shape memory effect and superelasticity, we investigated here the plastic deformation behaviour of a single crystal of α″ (orthorhombic) martensite of Ti-27 mol%Nb shape memory alloy obtained by the stress-induced martensitic transformation of a single crystal of the parent β phase. Four operative plastic deformation modes were observed, including two dislocation slips and two twinnings. To the best of our knowledge, two of these plastic deformation modes (one dislocation slip and one twinning) were discovered for the first time in this study. The identified slip and twinning systems in the martensite phase have corresponding slip and twinning systems in the parent β phase with which they share many similarities. Therefore, we believe that the plastic deformation of the α″ martensite is inherited from that of the parent β phase.
Usefulness of the delta neutrophil index to predict 30-day mortality in patients with ST segment elevation myocardial infarction
Authors: Kong Taeyoung , Kim Tae Hoon , Park Yoo Seok , Chung Sung Phil , Lee Hye Sun , Hong Jung Hwa , Lee Jong Wook , You Je Sung , Park Incheol 
Published: November 2017

AbstractThis study aimed to evaluate the association between the delta neutrophil index (DNI), which reflects immature granulocytes, and the severity of ST-elevation myocardial infarction (STEMI), as well as to determine the significance of the DNI as a prognostic marker for early mortality and other clinical outcomes in patients with STEMI who underwent reperfusion. This retrospective, observational cohort study was conducted using patients prospectively integrated in a critical pathway program for STEMI. We included 842 patients diagnosed with STEMI who underwent primary percutaneous coronary intervention (pPCI). Higher DNI values at time-I (within 2 h of pPCI; hazard ratio [HR], 1.075; 95% confidence interval [CI]: 1.046–1.108; p < 0.001) and time-24 (24 h after admission; HR, 1.066; 95% CI: 1.045–1.086; p < 0.001) were significant independent risk factors for 30-day mortality. Specifically, DNI values >2.5% at time-I (HR, 13.643; 95% CI: 8.13–22.897; p < 0.001) and > 2.9% at time-24 (HR, 12.752; 95% CI: 7.308–22.252; p < 0.001) associated with increased risks of 30-day mortality. In conclusion, an increased DNI value, which reflects the proportion of circulating immature granulocytes in the blood, was found to be an independent predictor of 30-day mortality and poor clinical outcomes in patients with acute STEMI post-pPCI.