bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research of ultrasonic sensors for measuring water flow in hydromelioration objects
Authors: Djalilov A , Nazarov O , Sobirov E , Gayipov I , Abdunabiev D , Urolov S 
Published: September 2024

Abstract
Currently, many countries are experiencing water shortages, which requires efficient use of available water resources. Therefore, there is an increasing need for simple, reliable and inexpensive water flow measurement devices with high measurement accuracy. This article researched an ultrasonic device for measuring water flow, operating on the basis of the time-pulse method. The device was based on an STM32 microcontroller, and a high-precision TDC-GP22 converter was used to generate ultrasonic signals and subsequently collect the difference in their propagation time. The main advantages of the proposed device are ease of use and low power consumption. The experiment’s findings indicate that the water flow meter being examined can be effectively utilized at hydromelioration sites.
From consumption to context: assessing poverty and inequality across diverse socio-ecological systems in Ghana
Authors: Cavanaugh Alicia C , Bixby Honor R , Mangwani Saeesh , Agyei-Mensah Samuel , Awuni Cynthia Azochiman , Baumgartner Jill C , Owusu George , Robinson Brian E 
Published: September 2024

Abstract
Local social and ecological contexts influence the experience of poverty and inequality in a number of ways that include shaping livelihood opportunities and determining the available infrastructure, services and environmental resources, as well as people’s capacity to use them. The metrics used to define poverty and inequality function to guide local and international development policy but how these interact with the local ecological contexts is not well explored. We use a social-ecological systems (SES) lens to empirically examine how context relates to various measures of human well-being at a national scale in Ghana. Using a novel dataset constructed from the 100% Ghanian Census, we examine poverty and inequality at a fine population level across and within multiple dimensions of well-being. First, we describe how well-being varies within different Ghanian SES contexts. Second, we ask whether monetary consumption acts a good indicator for well-being across these contexts. Third, we examine measures of inequality in various metrics across SES types. We find consumption distributions differ across SES types and are markedly distinct from regional distributions based on political boundaries. Rates of improved well-being are positively correlated with consumption levels in all SES types, but correlations are weaker in less-developed contexts like, rangelands and wildlands. Finally, while consumption inequality is quite consistent across SES types, inequality in other measures of living standards (housing, water, sanitation, etc) increases dramatically in SES types as population density and infrastructural development decreases. We advocate that SES types should be recognized as distinct contexts in which actions to mitigate poverty and inequality should better incorporate the challenges unique to each.
Deciphering the degradation of sulfonamides by UV/chlorination in aqueous solution: kinetics, reaction pathways, and toxicological evolution
Authors: Bano Shah , Shad Asam , Alqhtani Haifa A , Bin-Jumah May , Altoom Naif G , Allam Ahmed A 
Published: September 2024

Abstract
UV/Cl is a cost-effective process and is often used in municipal water treatment plants as well as in industrial applications. UV/Cl method is found highly effective in degrading contaminants, including pathogens, The conventional methods for water treatment have been proven inefficient for the complete elimination of pollutants and generate harmful by-products in the environment. This study evaluated the efficacy of three different treatment methods, chlorination alone, UV photolysis, and UV/Cl, for the degradation of sulfonamides (SAs) in water. The results highlighted that UV/Cl treatment was an efficient method for enhancing the degradation of sulfisoxazole (SFX), sulfadimethoxine (SAT), and sulfaguanidine (SG), with substrates degrading in 5, 6.5, and 4 min. The study also investigated the reactive species generated in the UV/Cl system and found that ·OH was the species responsible for the elimination of SFX. Additionally, the study explored the intermediate products generated during the degradation of SFX under the UV/Cl system, identifying VI distinct degradation pathways. The presence of ·OH radicals significantly enhanced the degradation of SFX, while some chlorine species also contributed to the degradation. The study predicted the toxicity of degradation products from the UV/Cl system using the ECOSAR (Ecological Structure Activity Relationships) program and found that the final degradation products of SFX were non-toxic, but concerns were raised about acute toxicity.
Evaluating D-InSAR performance to detect small water level fluctuations in two small lakes in Sweden
Authors: Aminjafari Saeid , Brown Ian A , Jaramillo Fernando 
Published: September 2024

Abstract
Monitoring lake water level fluctuations is critical for managing water resources, predicting the impacts of climatic change, and preserving ecosystem services lakes provide. However, traditional gauging stations are insufficient to monitor all lakes worldwide due to the large number of existing lakes, the challenges of installation and maintenance, and the remote locations of some. Although satellite altimetry is an alternative for measuring water levels, it cannot monitor small lakes effectively. This study evaluates the potential of Differential Interferometric Synthetic Aperture Radar (D-InSAR) for tracking minor water level changes in small lakes, a method more typically used in wetland studies. We investigate two Swedish lakes using Sentinel-1A and Sentinel-1B data from 2019, generating six-day interferograms and filtering out those with in situ water level changes exceeding one phase cycle. Our results show that D-InSAR can detect small water level changes with Lin’s correlations up to 0.63 and 0.89 and RMSE values of approximately 9 and 4 mm, respectively. These results evidence the potential of future L-band SAR missions with larger wavelengths, such as the NASA-ISRO SAR (NISAR) of the National Aeronautics and Space Administration (NASA) and the Indian Space Research Organisation (ISRO), to track water level changes in lakes and aid water tracking missions such as the SWOT (Surface Water and Ocean Topography).
Water structures and anisotropic dynamics at Pt(211)/water interface revealed by machine learning molecular dynamics
Authors: Wang Fei-Teng , Liu Xiandong , Cheng Jun 
Published: September 2024

Abstract
Water molecules at solid–liquid interfaces play a pivotal role in governing interfacial phenomena that underpin electrochemical and catalytic processes. The organization and behavior of these interfacial water molecules can significantly influence the solvation of ions, the adsorption of reactants, and the kinetics of electrochemical reactions. The stepped structure of Pt surfaces can alter the properties of the interfacial water, thereby modulating the interfacial environment and the resulting surface reactivity. Revealing the in situ details of water structures at these stepped Pt/water interfaces is crucial for understanding the fundamental mechanisms that drive diverse applications in energy conversion and material science. In this work, we have developed a machine learning potential for the Pt(211)/water interface and performed machine learning molecular dynamics simulations. Our findings reveal distinct types of chemisorbed and physisorbed water molecules within the adsorbed layer. Importantly, we identified three unique water pairs that were not observed in the basal plane/water interfaces, which may serve as key precursors for water dissociation. These interfacial water structures contribute to the anisotropic dynamics of the adsorbed water layer. Our study provides molecular-level insights into the anisotropic nature of water behavior at stepped Pt/water interfaces, which can influence the reorientation and distribution of intermediates, molecules, and ions—crucial aspects for understanding electrochemical and catalytic processes.
Efficacy of Closed-Incision Negative Pressure Wound Therapy in Reducing Postoperative Complications in Breast Reconstruction After Radiotherapy: A Propensity Score Analysis
Authors: Alameddine Khaled O , Salinas Cristina A , Yan Maria , Martinez-Jorge Jorys , Vijayasekaran Aparna , Tran Nho V , Harless Christin A 
Published: September 2024

Abstract

Background
Implant-based breast reconstruction following radiotherapy can lead to significant postoperative complications. Closed-incision negative pressure wound therapy (ciNPWT) has emerged as a potential intervention to reduce these complications.

Objectives
To assess the effectiveness of ciNPWT in reducing postoperative complications in patients undergoing implant-based breast reconstruction after radiotherapy.

Methods
A retrospective single-center cohort study was conducted, including patients who underwent implant-based breast reconstruction after mastectomy and radiotherapy between January 1, 2015, and December 31, 2022. We utilized a procedure-level analysis model with patients contributing distinct observations for multiple procedures. Our primary outcome measures included fluid collection, infection, and wound complications. Propensity score analysis was employed to adjust for potential confounders, such as BMI, smoking history, and diabetes history, creating a balanced comparison between the ciNPWT-treated and untreated groups.

Results
In our study of 301 breast reconstructions postradiotherapy from 2015 to 2022, encompassing 218 unique patients, we found significant benefits of ciNPWT. During an average of 2.2-year follow-up, the ciNPWT group demonstrated no infections, contrasting with a 10.4% rate in the non-ciNPWT group (P &lt; .0001). Wound complications were also significantly lower in the ciNPWT group (1.9% vs 11.2%; P = .00848). Demographic differences were adjusted using inverse probability of treatment weights. The findings suggest ciNPWT’s promising role in enhancing postoperative outcomes in breast reconstruction postradiotherapy.

Conclusions
Our study suggests that the use of ciNPWT in implant-based breast reconstruction postradiotherapy can potentially reduce postoperative complications. This intervention can improve patient outcomes and may offer cost-saving benefits in the long run.

Level of Evidence: 3 (Therapeutic)
ChatMol: interactive molecular discovery with natural language
Authors: Zeng Zheni , Yin Bangchen , Wang Shipeng , Liu Jiarui , Yang Cheng , Yao Haishen , Sun Xingzhi , Sun Maosong , Xie Guotong , Liu Zhiyuan 
Published: September 2024

Abstract

Motivation
Natural language is poised to become a key medium for human–machine interactions in the era of large language models. In the field of biochemistry, tasks such as property prediction and molecule mining are critically important yet technically challenging. Bridging molecular expressions in natural language and chemical language can significantly enhance the interpretability and ease of these tasks. Moreover, it can integrate chemical knowledge from various sources, leading to a deeper understanding of molecules.

Results
Recognizing these advantages, we introduce the concept of conversational molecular design, a novel task that utilizes natural language to describe and edit target molecules. To better accomplish this task, we develop ChatMol, a knowledgeable and versatile generative pretrained model. This model is enhanced by incorporating experimental property information, molecular spatial knowledge, and the associations between natural and chemical languages. Several typical solutions including large language models (e.g. ChatGPT) are evaluated, proving the challenge of conversational molecular design and the effectiveness of our knowledge enhancement approach. Case observations and analysis offer insights and directions for further exploration of natural-language interaction in molecular discovery.

Availability and implementation
Codes and data are provided in https://github.com/Ellenzzn/ChatMol/tree/main.
Imaging findings in suspected penile fracture: alternative diagnoses and surgical correlation
Authors: von Stempel Conrad , Kirkham Alex , Cayetano Alcaraz Axel , Ralph David , Christopher Nim , Muneer Asif , Sangster Pippa , Alnajjar Hussain , Li Chi-ying , Walkden Miles , Allen Clare , Pendse Doug , Ramachandran Navin , Heffernan Ho Dan , Dickinson Louise , Hubbard Rachel , Giganti Francesco , Lee Wai Gin 
Published: September 2024

Abstract

Objectives
The primary objective is to compare the imaging and surgical findings in a cohort of patients with suspected penile fracture (PF).

Methods
Retrospective cohort study of all patients with suspected PF over an 11-year period at a tertiary referral andrology centre. All dedicated presurgical imaging with ultrasound (US) and MRI was analysed and correlated with intraoperative findings; alternative diagnoses were recorded.

Results
One hundred and ninety-three patients were included. One hundred and four (54%) had alternative diagnoses to PF including dorsal vein rupture and haematoma. Ninety-nine (51%) underwent surgical exploration of which 89 (46%) had PF. US correctly confirmed the presence and marked the site of fracture in 92% of cases. MRI was primarily used as a problem-solving tool (13 cases) and demonstrated a more extensive injury than US (12 cases). The reported size of tunical defect on imaging was a median of 7 mm (IQR 4-10) significantly smaller than on exploration (median 20 mm, IQR 10-30; P &lt; .0001).

Conclusions
US has a high positive predictive value in the confirmation of PF. MRI improves the detection and characterizing the extent of injury. Imaging marking informs surgical incision but defect size is under appreciated on all imaging modalities.

Advances in knowledge
Penile imaging has a high positive predictive value to not only confirm the diagnosis of PF but to stage the extent of injury and mark the skin, which impacts the surgical technique. Alternative diagnoses to fracture are common and imaging could prevent unnecessary surgical exploration.
Impact of mechanical bowel preparation on the gut microbiome of patients undergoing left-sided colorectal cancer surgery: randomized clinical trial
Authors: Žukauskaitė Kristina , Horvath Angela , Gricius Žilvinas , Kvietkauskas Mindaugas , Baušys Bernardas , Dulskas Audrius , Kuliavas Justas , Baušys Rimantas , Letautienė Simona Rūta , Vaicekauskaitė Ieva , Sabaliauskaitė Rasa , Baušys Augustinas , Stadlbauer Vanessa , Jarmalaitė Sonata 
Published: September 2024

Abstract

Background
Postoperative complications after colorectal cancer surgery have been linked to the gut microbiome. However, the impact of mechanical bowel preparation using oral preparation agents or rectal enema on postoperative infections remains poorly understood. This study aimed to compare the impact of oral preparation and rectal enema on the gut microbiome and postoperative complications.

Methods
This open-label pilot RCT was conducted at the National Cancer Institute, Vilnius, Lithuania. Patients with left-side colorectal cancer scheduled for elective resection with primary anastomosis were randomized 1 : 1 to preoperative mechanical bowel preparation with either oral preparation or rectal enema. Stool samples were collected before surgery, and on postoperative day 6 and 30 for 16S rRNA gene sequencing analysis. The primary outcome was difference in β-diversity between groups on postoperative day 6.

Results
Forty participants were randomized to oral preparation (20) or rectal enema (20). The two groups had similar changes in microbiome composition, and there was no difference in β-diversity on postoperative day 6. Postoperative infections occurred in 12 patients (32%), without differences between the study groups. Patients with infections had an increased abundance of bacteria from the Actinomycetaceae family, Actinomyces genus, Sutterella uncultured species, and Enterococcus faecalis species.

Conclusion
Mechanical bowel preparation with oral preparation or rectal enema resulted in similar dysbiosis. Patients who experienced postoperative infections exhibited distinct gut microbiome compositions on postoperative day 6, characterized by an increased abundance of bacteria from the Actinomycetaceae family, Actinomyces genus, Sutterella uncultured species, and Enterococcus faecalis species.

Registration number
NCT04013841 (http://www.clinicaltrials.gov).
Deciphering the physiopathology of neurodevelopmental disorders using brain organoids
Authors: Dionne Olivier , Sabatié Salomé , Laurent Benoit 
Published: September 2024

Abstract
Neurodevelopmental disorders (NDD) encompass a range of conditions marked by abnormal brain development in conjunction with impaired cognitive, emotional and behavioural functions. Transgenic animal models, mainly rodents, traditionally served as key tools for deciphering the molecular mechanisms driving NDD physiopathology and significantly contributed to the development of pharmacological interventions aimed at treating these disorders. However, the efficacy of these treatments in humans has proven to be limited, due in part to the intrinsic constraint of animal models to recapitulate the complex development and structure of the human brain but also to the phenotypic heterogeneity found between affected individuals. Significant advancements in the field of induced pluripotent stem cells (iPSCs) offer a promising avenue for overcoming these challenges. Indeed, the development of advanced differentiation protocols for generating iPSC-derived brain organoids gives an unprecedented opportunity to explore human neurodevelopment.
This review provides an overview of how 3D brain organoids have been used to investigate various NDD (i.e. Fragile X syndrome, Rett syndrome, Angelman syndrome, microlissencephaly, Prader-Willi syndrome, Timothy syndrome, tuberous sclerosis syndrome) and elucidate their pathophysiology. We also discuss the benefits and limitations of employing such innovative 3D models compared to animal models and 2D cell culture systems in the realm of personalized medicine.
Peracetic acid efficacy on disinfection of photostimulable phosphor plates
Authors: Ruiz Débora Costa , Ocampo Thaís Santos Cerqueira , Franco Eduardo Martinelli , Correia-Dantas Iago Filipe , Mattos-Graner Renata de Oliveira , Haiter-Neto Francisco , Freitas Deborah Queiroz 
Published: September 2024

Abstract

Objectives
To evaluate the antimicrobial efficacy of white vinegar, acetic acid, and peracetic acid on photostimulable phosphor (PSP) plates disinfection, and to assess the disinfectant influence on the radiographic quality.

Methods
Eight PSP plates (Express system) were contaminated with Streptococcus mutans and Candida albicans. These plates were wiped with tissues without any substance, with white vinegar, acetic acid, and peracetic acid, followed by an agar imprint. Number of microbial colonies formed was recorded. Afterwards, the quality of radiographs was tested using the more efficient disinfectant. Before disinfection and after every five disinfections, two radiographs of an acrylic-block and two radiographs of an aluminium step-wedge were acquired for each plate. Density, noise, uniformity, and contrast were analysed. Three oral radiologists evaluated the images for the presence of artefacts. One-way analysis of variance compared changes on grey values among the disinfections (α = .05). Intra- and inter-examiner agreement for the presence of artefacts was calculated by weighted Kappa.

Results
Peracetic acid was the only one that eliminated both microorganisms. Density and uniformity decreased after 100 disinfections, and contrast changed without a pattern in the course of disinfections (P ≤ .05). Small artefacts were observed after 30 disinfections. Intra- and inter-examiner agreements were almost perfect.

Conclusions
Disinfection with peracetic acid eliminated both microorganisms. However, it also affected density, uniformity, and contrast of radiographs, and led to the formation of small artefacts.
251. THE COMPARISON OF UNIPORTAL VERSUS MULTIPORTAL VIDEO-ASSISTED THORACIC SURGERY FOR ESOPHAGEAL CANCER: A PROPENSITY-WEIGHTED ANALYSIS
Authors: Yuan Yong 
Published: September 2024

Abstract

Background
Uniportal video-assisted thoracoscopic surgery (VATS) has been widely used, however, there are few studies on uniportal VATS for esophagectomy.

Methods
Data from patients with clinical stage T1–3/N0/M0 thoracic esophageal cancer who underwent surgery between January 2017 and December 2020 were retrospectively collected and retrospectively analyzed. Inverse probability of treatment weighting (IPTW) analysis was performed to assess the outcomes.

Results
Overall, 55 patients who underwent uniportal, and 212 patients who underwent multiportal, VATS were identified. Surgery-related postoperative complications (Clavien-Dindo grades 1–2) occurred less frequently after uniportal than multiportal VATS in both crude and IPTW models (10.1% versus 28.8%, respectively; P = 0.018). The median postoperative length of stay was 9 (9–10) days in the uniportal VATS and 10 (9–14) days in the multiportal VATS group (P = 0.006 after IPTW). Upon IPTW analysis, in uniportal and multiportal VATS groups, the rates of pneumonia (grades 1-2) were 7.3% and 23.2% (P = 0.037). The visual analog scale (VAS) was administered on postoperative first 7 days and were significantly lower in the uniportal VATS group (P &lt; 0.001). No surgical mortality was observed in the uniportal VATS group, and the survival benefit between the two groups was comparable before (P = 0.320) and after IPTW (P = 0.824).

Conclusion
Uniportal VATS for esophagectomy resulted in a lower rate of postoperative complications with less postoperative pain, and is practical for treating patients with esophageal cancer.