bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presentation, Management, and Outcomes of Patients With Giant Pheochromocytoma
Authors: Bahrani Fard Bahar , Nikravangolsefid Nasrin , Maroun Justin W , Cross Ashton , Foster Trenton , McKenzie Travis J , Dy Benzon , Lyden Melanie , Young William F , Bancos Irina 
Published: September 2024

Abstract

Context
Data on giant pheochromocytomas (PHEOs), defined based on size 10 cm or greater, are scarce.

Objective
This work aimed to compare presentation, management, and outcomes of patients with giant vs non–giant PHEOs.

Methods
A retrospective cohort study was conducted in a referral center from 2000 to 2023. Consecutive patients with giant PHEOs and randomly chosen patients with non–giant PHEO (referents) were studied at a 1:6 ratio. Outcomes included perioperative complications, metastases, and mortality.

Results
Of 828 patients with PHEOs, 31 (3.7%) had giant PHEO (median size 12 cm, interquartile range [IQR] 10.0-13.5 cm). In comparison to referents (n = 186, median size 4 cm, IQR, 2.9-5.0 cm), patients with giant PHEO had more symptoms of catecholamine excess (median of 2 vs 1; P = .04) and presented with a higher prevalence of severe catecholamine excess (76% vs 30%; P &lt; .0001). Adrenalectomy was performed in 94% of patients with giant PHEOs and 100% of referents. In addition to preoperative α-adrenergic blockade (89%), metyrosine was used in 14 (7%) patients, mostly in patients with giant PHEOs (26% vs 3%; P &lt; .0001). Patients with giant PHEOs had a higher perioperative complication rate (31% vs 10%; P = .004). During a median follow-up of 3 years, metastases developed at a higher rate in patients with giant PHEOs (45% vs 4% in referents; P &lt; .0001). Disease-specific mortality was 7% in patients with giant PHEOs and 0% in referents (P = .02).

Conclusion
Patients with giant PHEOs compared to referents were more symptomatic, had a higher degree of catecholamine excess, and had a higher rate of perioperative complications. Almost half of patients with giant PHEOs developed metastases, warranting close follow-up.
Downregulation of CerS4 Instead of CerS2 in Liver Effectively Alleviates Hepatic Insulin Resistance in HFD Male Mice
Authors: Roszczyc-Owsiejczuk Kamila , Zabielski Piotr , Imierska Monika , Pogodzińska Karolina , Sadowska Patrycja , Błachnio-Zabielska Agnieszka 
Published: September 2024

Abstract

Objective
Consumption of a high-fat diet (HFD) induces insulin resistance (IRes), significantly affecting the maintenance of normal glucose homeostasis. Nevertheless, despite decades of extensive research, the mechanisms and pathogenesis of IRes remain incomplete. Recent studies have primarily explored lipid intermediates such as diacylglycerol (DAG), given a limited knowledge about the role of ceramide (Cer), which is a potential mediator of the IRes in the liver.

Methods
In order to investigate the role of Cer produced by CerS2 and CerS4 for the purpose of inducing the hepatic IRes, we utilized a unique in vivo model employing shRNA-mediated hydrodynamic gene delivery in the liver of HFD-fed C57BL/6J mice.

Results
Downregulation of CerS4 instead of CerS2 reduced specific liver Cers, notably C18:0-Cer and C24:0-Cer, as well as acylcarnitine levels. It concurrently promoted glycogen accumulation, leading to enhanced insulin sensitivity and glucose homeostasis.

Conclusion
Those findings demonstrate that CerS4 downregulating lowers fasting blood glucose levels and mitigates the HFD-induced hepatic IRes. It suggests that inhibiting the CerS4-mediated C18:0-Cer synthesis holds a promise to effectively address insulin resistance in obesity.
Η χρήση του Μοντέλου Διερεύνησης (CoI) κατά την εφαρμογή της επείγουσας απομακρυσμένης διδασκαλίας (ERT) ως δείκτη αποτελεσματικής μάθησης στο λύκειο
Authors: Μάλαμα Σταυρούλα , Avgerinou Maria D. 
Published: September 2024

Η επικράτηση της επείγουσας απομακρυσμένης διδασκαλίας (Emergency Remote Teaching –ERT) στην εκπαιδευτική κοινότητα, κατά τo Covid -19, αποκάλυψε κατά πόσο οι εκπαιδευτικοί διέθεταν την ετοιμότητα και τις δεξιότητες να ανταποκριθούν στις εκπαιδευτικές προκλήσεις που δημιουργήθηκαν. Στόχος της παρούσας εργασίας ήταν να αποτιμηθεί, βάσει των απόψεων των εκπαιδευτικών, η εκπαιδευτική διαδικασία κατά την εφαρμογή της ERT, σε σχολική μονάδα των Χανίων, με έμφαση στην αξιοποίηση, προς όφελος των εκπαιδευτικών, των αδυναμιών τους σε συνάρτηση με την ηλεκτρονική μάθηση. Για τη συγκεκριμένη μελέτη περίπτωσης χρησιμοποιήθηκε η μικτή ερευνητική μέθοδος. Διερευνήθηκε η ετοιμότητα ανταπόκρισης των εκπαιδευτικών στις ανάγκες της εξΑΕ, ο βαθμός κατάκτησης εκ μέρους τους της Διδακτικής, Κοινωνικής και Γνωστικής Παρουσίας, ο βαθμός ικανοποίησής τους από το σχεδιασμό και την υλοποίηση της εκπαιδευτικής διαδικασίας, η χρήση των συστημάτων διαχείρισης μάθησης καθώς και η εμπειρία τους αναφορικά με την τηλεκπαίδευση και την καλλιέργεια των δεξιοτήτων του 21ου αιώνα. Τα αποτελέσματα της έρευνας έδειξαν ότι οι εκπαιδευτικοί αντιμετώπισαν δυσκολίες λόγω της μη έγκαιρης και επαρκούς επιμόρφωσής τους στην παιδαγωγική χρήση των νέων τεχνολογιών. Παράλληλα, αναδείχτηκε η αναγκαιότητα της απόκτησης και αξιοποίησης των δεξιοτήτων του 21ου αιώνα στην διδασκαλία, προκειμένου αυτοί να ανταπεξέλθουν αποτελεσματικά στις απαιτήσεις ενός σύγχρονου εκπαιδευτικού περιβάλλοντος.
Mechanical influence of facet tropism in patients with chronic discogenic pain disorder
Authors: Lee Jun Y. , Lee Hae I. , Lee Sang-Heon , Kim Nack H. 
Published: September 2024

AimsThe presence of facet tropism has been correlated with an elevated susceptibility to lumbar disc pathology. Our objective was to evaluate the impact of facet tropism on chronic lumbosacral discogenic pain through the analysis of clinical data and finite element modelling (FEM).MethodsRetrospective analysis was conducted on clinical data, with a specific focus on the spinal units displaying facet tropism, utilizing FEM analysis for motion simulation. We studied 318 intervertebral levels in 156 patients who had undergone provocation discography. Significant predictors of clinical findings were identified by univariate and multivariate analyses. Loading conditions were applied in FEM simulations to mimic biomechanical effects on intervertebral discs, focusing on maximal displacement and intradiscal pressures, gauged through alterations in disc morphology and physical stress.ResultsA total of 144 discs were categorized as ‘positive’ and 174 discs as ‘negative’ by the results of provocation discography. The presence of defined facet tropism (OR 3.451, 95% CI 1.944 to 6.126) and higher Adams classification (OR 2.172, 95% CI 1.523 to 3.097) were important predictive parameters for discography-‘positive’ discs. FEM simulations showcased uneven stress distribution and significant disc displacement in tropism-affected discs, where loading exacerbated stress on facets with greater angles. During varied positions, notably increased stress and displacement were observed in discs with tropism compared to those with normal facet structure.ConclusionOur findings indicate that facet tropism can contribute to disc herniation and changes in intradiscal pressure, potentially exacerbating disc degeneration due to altered force distribution and increased mechanical stress.Cite this article:Bone Joint Res 2024;13(9):452–461.
Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies
Authors: Moraes Francisco Cezar Aquino de , Souza Maria Eduarda Cavalcanti , Dal Moro Lucca , Donadon Isabelle Batista , da Silva Emanuele Rocha , de Souza Dilma do Socorro Moraes , Burbano Rommel Mario Rodríguez 
Published: September 2024

Background
Maternal-foetal transmission of Chagas disease (CD) affects newborns worldwide. Although Benznidazole and Nifurtimox therapies are the standard treatments, their use during pregnancy is contra-indicated. The effectiveness of trypanocidal medications in preventing congenital Chagas Disease (cCD) in the offsprings of women diagnosed with CD was highly suggested by other studies.

Methods
We performed a systematic review and meta-analysis of studies evaluating the effectiveness of treatment for CD in women of childbearing age and reporting frequencies of cCD in their children. PubMed, Scopus, Web of Science, Cochrane Library, and LILACS databases were systematically searched. Statistical analysis was performed using Rstudio 4.2 using DerSimonian and Laird random-effects models. Heterogeneity was examined with the Cochran Q test and I2 statistics. A p-value of <0.05 was considered statistically significant.

Results
Six studies were included, comprising 744 children, of whom 286 (38.4%) were born from women previously treated with Benznidazole or Nifurtimox, trypanocidal agents. The primary outcome of the proportion of children who were seropositive for cCD, confirmed by serology, was signigicantly lower among women who were previously treated with no congenital transmission registered (OR 0.05; 95% Cl 0.01–0.27; p = 0.000432; I2 = 0%). In women previously treated with trypanocidal drugs, the pooled prevalence of cCD was 0.0% (95% Cl 0–0.91%; I2 = 0%), our meta-analysis confirms the excellent effectiveness of this treatment. The prevalence of adverse events in women previously treated with antitrypanocidal therapies was 14.01% (95% CI 1.87–26.14%; I2 = 80%), Benznidazole had a higher incidence of side effects than Nifurtimox (76% vs 24%).

Conclusion
The use of trypanocidal therapy in women at reproductive age with CD is an effective strategy for the prevention of cCD, with a complete elimination of congenital transmission of Trypanosoma cruzi in treated vs untreated infected women.
Isolation and characterization of genetic variants of Orthohantavirus hantanense from clinical cases of HFRS in Jiangxi Province, China
Authors: Liu Shiwen , Deng Zhishi , Li Jianxiong , Zou Long , Sun Xiuhui , Liu Xiaoqing , Shi Yong , Huang Shunqiang , Wu Yangbowen , Lei Jinhui , Liu Peipei , Zhang Pei , Xiong Ying , Long Zhong-er 
Published: September 2024

Background
Hemorrhagic fever with renal syndrome (HFRS) is a severe public health problem in Jiangxi province, China. Previous studies reported genetic variants of Orthohantavirus hantanense (Hantaan virus, HTNV) in rodents in this area. However, the relationship between HTNV variants and human infection needs to be confirmed. This study aimed to identify the HTNV variants in patients and to understand the clinical characteristics of HFRS caused by these variants.

Methods
Samples were collected from hospitalized suspected cases of HFRS during the acute phase. HFRS cases were confirmed using quantitative real-time RT-PCR. Peripheral blood mononuclear cells (PBMC) from patients with HFRS were inoculated into Vero-E6 cells for viral isolation. The genomic sequences of HTNV from patients were obtained by amplicon-based next-generation sequencing. A retrospective analysis was conducted on the clinical characteristics of the patients.

Results
HTNV RNA was detected in 53 of 183 suspected HFRS patients. Thirteen HTNVs were isolated from 32 PBMCs of HFRS cases. Whole genome sequences of 14 HTNVs were obtained, including 13 isolates in cell culture from 13 patients, and one from plasma of the fatal case which was not isolated successfully in cell culture. Genetic analysis revealed that the HTNV sequence from the 14 patients showed significant variations in nucleotide and amino acid to the HTNV strains found in other areas. Fever (100%, 53/53), thrombocytopenia (100%, 53/53), increased serum aspartate aminotransferase (100%, 53/53), and increased lactate dehydrogenase (96.2%, 51/53) were the most common characteristics. Severe acute kidney injury was observed in 13.2% (7/53) of cases. Clinical symptoms, such as pain, petechiae, and gastrointestinal or respiratory symptoms were uncommon.

Conclusion
The HTNV genetic variants cause human infections in Jiangxi. The clinical symptoms of HFRS caused by the HTNV genetic variant during the acute phase are atypical. In addition to renal dysfunction, attention should be paid to the common liver injuries caused by these genetic variants.
The effect of excessive trabeculation on cardiac rotation—A multimodal imaging study
Authors: Grebur Kinga , Mester Balázs , Horváth Márton , Farkas-Sütő Kristóf , Gregor Zsófia , Kiss Anna Réka , Tóth Attila , Kovács Attila , Fábián Alexandra , Lakatos Bálint Károly , Fekete Bálint András , Csonka Katalin , Bödör Csaba , Merkely Béla , Vágó Hajnalka , Szűcs Andrea 
Published: September 2024

Background
Cardiac rotational parameters in primary symptomatic left ventricular noncompaction (LVNC) with preserved left ventricular ejection fraction (LVEF) are not well understood. We aimed to analyze cardiac rotation measured with cardiac magnetic resonance feature-tracking (CMR-FT) and speckle-tracking echocardiography (Echo-ST) in LVNC morphology subjects with preserved LVEF and different genotypes and healthy controls.

Methods
Our retrospective study included 54 LVNC subjects with preserved LVEF and 54 control individuals. We evaluated functional and rotational parameters with CMR in the total study population and with echocardiography in 39 LVNC and 40 C individuals. All LVNC subjects were genotyped with a 174-gene next-generation sequencing panel and grouped into the subgroups: benign (B), variant of uncertain significance (VUS), and pathogenic (P).

Results
In comparison with controls, LVNC subjects had reduced apical rotational degree (p = 0.004) and one-third had negative apical rotation. While the degree of apical rotation was comparable between the three genetic subgroups, they differed significantly in the direction of apical rotation (p<0.001). In contrast to control and B groups, all four studied cardiac rotational patterns were identified in the P and VUS subgroups, namely normal rotation, positive and negative rigid body rotation, and reverse rotation. When the CMR-FT and Echo-ST methods were compared, the direction and pattern of cardiac rotation had moderate to good association (p<0.001) whereas the rotational degrees showed no reasonable correlation or agreement.

Conclusion
While measuring cardiac rotation using both CMR-FT and Echo-ST methods, subclinical mechanical differences were identified in subjects with LVNC phenotype and preserved LVEF, especially in cases with genetic involvement.
Extended-release metformin in patients with prediabetes, chro­nic heart failure and abdominal obesity in light of the effect on fat depot compartments and glucose metabolism parameters
Authors: Tsygankova O. V. , Apartseva N. E. , Latyntseva L. D. , Ryabikov A. N. 
Published: September 2024

BACKGROUND: Considering the role of visceral adipose tissue deposition in the pathogenesis of heart failure with preserved ejection fraction (HFpEF) and the positive effect of metformin on weight loss, the effect of this drug on adipose tissue compartments in patients with HFpEF is interest.AIM: To study the effect of extended-release metformin (XR) on various fat depots and parameters of insulin-glucose homeostasis in patients with HFpEF, prediabetes and abdominal obesity (AO).MATERIALS AND METHODS: Study design: single-center, open-ended, randomized, prospective, controlled. The registration numbers of the study in the NARNIS register RNI.25.004. The study included 64 people (50% men, median age 58 [55.25; 59.75] years) with HFpEF, prediabetes and AO. All patients (groups A and B) received optimal HFpEF therapy. In group A (n=32), metformin XR 1000–1500 mg/day was additionally prescribed. All patients underwent general clinical examination, calculation of insulin resistance indices, ultrasound lipometry to determine the thickness of epicardial, preperitoneal and subcutaneous fat initially and after 6 months.RESULTS: In group A patients, there was a decrease in waist circumference by 0.9% (p=0.002), hip circumference by 1.25% (p=0.001), body weight by 4.7% (p<0.0001), body mass index by 1.8% (p=0.001) compared with baseline. In the control group, the anthropometric parameters of the dynamics did not change. Also, in the metformin XR group, glucose levels decreased by 4.6% (p=0.009), glycated hemoglobin by 3.3% (p=0.047), insulin by 12.5% (p=0.024) and insulin resistance indices: HOMA-IR by 19.8% (p=0.009), FIRI by 19.8% (p=0.009). In contrast, patients from group B had an increase in fasting plasma insulin levels by 33.6% (p=0.035), with an increase in HOMA-IR indices by 27.4% (p=0.026) and FIRI by 26.9% (p=0.025). The dynamics of ultrasound lipometry parameters was observed only in group A: the thickness of the preperitoneal fat decreased by 14.5% (p<0.0001), the thickness of the subcutaneous fat decreased by 12.3% (p<0.0001).CONCLUSION: In patients with prediabetes, HFpEF and AO, taking metformin XR 1000-1500 mg/day for 6 months against the background of optimal basic HFpEF therapy was associated with a decrease in subcutaneous and preperitoneal fat, also had a beneficial effect on glucose metabolism parameters compared with the control group.
eLearning lecturer workload
Authors: Bright Stephen 
Published: September 2024

Lecturers who move into the online learning environment often discover that the workload involved not only changes, but can be overwhelming as they cope with using digital technologies. Questions arise, given the dissatisfaction of lecturers with lowering morale and increasing workload, whether future expansion of this teaching component in tertiary institutions is sustainable. The challenge facing lecturers now, and in the future, is about learning workload management strategies which effectively manage the workload they encounter in the online learning environment. This paper describes a case study (which is a work-in-progress) examining the perceptions of online workload cf. face-to-face teaching of lecturers who are experienced in e- teaching. As well, it identifies strategies the lecturers have developed or adopted to manage this element of their workload.

Keywords: lecturer workload, workload strategies, workload management , e-teaching, elearning
Statuiert Kants theoretische Philosophie eine radikale negative Theologie? Anmerkungen zu einer These aus der jüngeren Forschung im Lichte von Kants regulativem Deismus
Authors: Wyrwich Thomas 
Published: September 2024

Abstract
Markus Kohl, Ruben Schneider and (in substance) Marcus Willaschek have recently argued that Kant’s theoretical philosophy includes a radical negative theology. This article criticises this radical reading. On the one hand, it argues that different Kantian passages that seem to speak for the absolute incomprehensibility of the highest being can be interpreted as showing that Kant merely rejects comprehensibility according to the pattern of schematised cognition of the understanding (there is no concrete cognition of God). The paper goes on to show that Kant advocates a form of ‘regulative deism’ (although he also associates deism with a form of atheism) and that the analytical conclusions of deistic transcendental theology are no less substantial in principle than those of the Transcendental Aesthetic of the KrV. What Kohl’s, Schneider’s and Willaschek’s interpretations lose sight of is the fact that Kant continuously characterises the highest being conceived by reason in the KrV as a “faultless ideal.”
Bedingungen für gelingende berufliche Reha-Verläufe von Menschen mit psychischen Erkrankungen aus der Perspektive verschiedener Akteure
Authors: Reims Nancy , Tophoven Silke , Rauch Angela 
Published: September 2024

Zusammenfassung
Menschen mit psychischen Erkrankungen sind mit besonderen Herausforderungen bei der Integration und Reintegration in den Arbeitsmarkt konfrontiert. Leistungen zur Teilhabe am Arbeitsleben (LTA) sollen dabei unterstützen. Der vorliegende Beitrag blickt auf die Situation von Menschen mit psychischen Erkrankungen in LTA der Bundesagentur für Arbeit aus verschiedenen Perspektiven. Auf Grundlage von qualitativen Interviews mit Tätigen bei Leistungserbringern, in Agenturen für Arbeit und Jobcentern sowie von beruflichen Rehabilitand*innen mit psychischen Erkrankungen selbst werden Gelingensbedingungen für ihre berufliche Rehabilitation und Arbeitsmarktintegration auf verschiedenen Ebenen herausgearbeitet. Mehr Individualität und Flexibilität in der Maßnahmeerbringung, eine kontinuierliche Betreuung und der Faktor Zeit, z. B. durch einerseits zu lange Wartezeiten und andererseits zu wenig Zeit in der Klärungsphase (Diagnostik, Assessment), im Rehabilitationsprozess und für die Nachsorge, stellen sich dabei als zentral heraus.
Simultaneous determination of cinnarizine and domperidone in marketed tablets using a green HPTLC method
Authors: Alam Prawez , Shakeel Faiyaz 
Published: September 2024

AbstractCurrently, there are no reported green “high-performance thin-layer chromatography (HPTLC)” methods for domperidone (DOM) and cinnarizine (CNZ) simultaneous detection. The objective of the present study was to design and verify a reverse-phase HPTLC method for the concurrent analysis of CNZ and DOM in commercial tablets that is fast, sensitive, and greener. As a green mobile phase, acetone and water in an 80:20 (v/v) binary ratio were used to simultaneously determine CNZ and DOM. The stationary phase was reverse-phase silica gel 60F254S plates. Concurrent measurements of CNZ and DOM were performed at 230 nm. Four different tools were used to assess the greenness of the current method: AGREE, AES, ChlorTox, and NEMI. For both medications, the current approach was linear in the 25–1,000 ng/band range. The accuracy, precision, robustness, sensitivity, and environmental friendliness of the suggested technique for the CNZ and DOM simultaneous detection were verified. The new method's profile was noticeably greener, as seen by the results of every greenness tool, including NEMI, AES (89), ChlorTox (1.08 g), and AGREE (0.83). Utilizing the current approach, the amount of CNZ and DOM in pharmaceutical tablets was found to be 99.53 and 98.87%, respectively. These findings validate the suitability of the existing method for measuring CNZ and DOM simultaneously in commercial tablets. The results of the proposed study indicated that measuring CNZ and DOM in commercial products could be done consistently with the current methodology.
Spatio-temporal EEG dynamics during decision-making in online poker players with problem gambling
Authors: Giustiniani Julie , Nicolier Magali , Maylié Florine , Pazart Lionel , Haffen Emmanuel , Gabriel Damien 
Published: September 2024

AbstractBackground and aimsGambling activity evolves along a continuum from recreational to Gambling Disorder (GD) and a particular challenge is to identify whether there are some neurophysiological particularities already present in gamblers at an early stage. Our main goal was to determine whether, in the gamblers' population, neural responses generated during uncertain decisions were different depending on problematic gambling risk defined by the Canadian Problem Gambling Index (CPGI). We tested the following hypothesis, that the Problem Gambling group would show a different brain activity related to outcomes processing than people with low risk.MethodsFor this purpose, we established a relatively homogeneous population of Online Poker Players divided into two groups according to the CPGI (Low Risk and Problem Gambling). By means of high-density EEG, we compared the spatio-temporal dynamics generated during the completion of the Iowa Gambling Task.ResultsOne specific topographic map was observed between 150–175 ms after a negative outcome for both groups, whereas it was displayed in the win condition only for the Problem Gambling group. We found that the Global Field Power of this map was negatively correlated with participants' adherence to a strategy. Source localization identified Anterior Cingulate Cortex and Temporal regions as generators of this map.Discussion and conclusionsReward hypersensitivity EEG responses identified in the early outcome process could constitute a potential biomarker of problematic gambling.