bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of CD34+ cell migration by matrix metalloproteinase-2 during acute myocardial ischemia, counteracted by ischemic preconditioning
Authors: Lukovic Dominika , Zlabinger Katrin , Gugerell Alfred , Spannbauer Andreas , Pavo Noemi , Mandic Ljubica , Weidenauer Denise T. , Kastl Stefan , Kaun Christoph , Posa Aniko , Sabdyusheva Litschauer Inna , Winkler Johannes , Gyöngyösi Mariann 
Published: February 2017

Background. Mobilization of bone marrow-origin CD34+ cells was investigated 3 days (3d) after acute myocardial infarction (AMI) with/without ischemic preconditioning (IP) in relation to stromal-derived factor-1 (SDF-1α)/ chemokine receptor type 4 (CXCR4) axis, to search for possible mechanisms behind insufficient cardiac repair in the first days post-AMI. Methods. Closed-chest reperfused AMI was performed by percutaneous balloon occlusion of the mid-left anterior descending (LAD) coronary artery for 90min, followed by reperfusion in pigs. Animals were randomized to receive either IP initiated by 3x5min cycles of re-occlusion/re-flow prior to AMI (n=6) or control AMI (n=12). Blood samples were collected at baseline, 3d post-AMI, and at 1-month follow-up to analyse chemokines and mobilized CD34+ cells. To investigate the effect of acute hypoxia, SDF-1α and matrix metalloproteinase (MMP)-2 in vitro were assessed, and a migration assay of CD34+ cells toward cardiomyocytes was performed. Results. Reperfused AMI induced significant mobilisation of CD34+ cells (baseline: 260±75 vs. 3d: 668±180; P<0.001) and secretion of MMP-2 (baseline: 291.83±53.40 vs. 3d: 369.64±72.89; P=0.011) into plasma, without affecting the SDF-1α concentration. IP led to the inhibition of MMP-2 (IP: 165.67±47.99 vs. AMI: 369.64±72.89; P=0.004) 3d post-AMI, accompanied by increased release of SDF-1α (baseline: 23.80±12.36 vs. 3d: 45.29±11.31; P=0.05) and CXCR4 (baseline: 0.59±0.16 vs. 3d: 2.06±1.42; P=0.034), with a parallel higher level of mobilisation of CD34+ cells (IP: 881±126 vs. AMI: 668±180; P=0.026), compared to non-conditioned AMI. In vitro, CD34+ cell migration toward cardiomyocytes was enhanced by SDF-1α, which was completely abolished by 90min hypoxia and co-incubation with MMP-2. Conclusions. Non-conditioned AMI induces MMP-2 release, hampering the ischemia-induced increase in SDF-1α and CXCR4 by cleaving the SDF-1α/CXCR4 axis, with diminished mobilization of the angiogenic CD34+ cells. IP might influence CD34+ cell mobilization via inhibition of MMP-2.
Organization Design, Proximity, and Productivity Responses to Upward Social Comparison
Authors: Obloj Tomasz , Zenger Todd 
Published: February 2017

We investigate the mechanisms that shape social comparison in organizations and generate social comparison costs. In particular, we focus on heterogeneity in the strength and type of incentives and argue that, from an efficient design perspective, such variance in rewards is a double-edged sword. While the sorting and incentive effects that result may increase productivity, the social comparison processes that arise may dampen it. We posit that the mechanisms underlying these behavioral costs are shaped not only by the magnitude of reward variance, but by the formal and informal design elements shaping the distance of advantaged peers. In other words, the more proximate socially, structurally, or geographically are those to whom one socially compares, the larger the behavioral response. Empirically, we use an unanticipated event during which outlets of a bank, previously operating under essentially homogenous incentives, were assigned to tournament groups with differing ex ante probabilities of winning a prize—an event that increases variance in awards and hence generates an impetus for social comparison. We find that units with more socially, geographically, and structurally proximate peers assigned to ”advantaged” tournament groups decreased their productivity. We discuss implications of these results for organizational design and boundaries.The online appendix is available at https://doi.org/10.1287/orsc.2016.1103 .
O horizonte da justiça transicional em Uruguai | The horizon of transitional justice in Uruguay
Authors: Roldan Andrés Del Río 
Published: February 2017

A investigação e o castigo às violações dos direitos humanos das ditaduras nos países da América Latina se tornaram uma questão inevitável para o fortalecimento e a consolidação das democracias da região. No presente trabalho, observaremos os principais eventos no processo de justiça transicional no Uruguai desde o governo de Jose Pepe Mujica até os dias de hoje (2010-2016). Analisaremos os principais eventos recentes observando a participação dos (e nos) tribunais no processo de luta pela memória, verdade e justiça. Examinaremos as novidades e desafios no horizonte da justiça transicional no Uruguai. O estudo tenta colaborar com o debate atual sobre os processos de revisão do passado violento na nossa região, desde a perspectiva da justiça transicional.ABSTRACTThe investigation and punishment for violations of the human rights of dictatorships in Latin America have become an unavoidable issue for the strengthening and consolidation of democracies in the region. In this paper, we will observe the major events in the transitional justice process in Uruguay since the government of Jose Pepe Mujica to the present day (2010-2016). We will review the main recent events observing the participation of (and in) the courts in the struggle for memory, truth and justice. We will examine the new challenges on the horizon of transitional justice in Uruguay. The study attempts to collaborate in the current debate about the violent past review processes in our region, from the perspective of transitional justice.Palavras-chave: Justiça transicional; Lei de Caducidade; Ditadura; Suprema Corte de Justiça; UruguaiKeywords: Transitional Justice; Law Forfeiture; Dictatorship; Supreme Court; UruguayDOI: 10.12957/rmi.2016.25242Recebido em 08 de Outubro de 2016 | Aceito em 15 de Dezembro de 2016Received on October 08, 2016 | Accepted on December 15, 2016
Improving documentation in surgical operation notes
Authors: Parwaiz Hammad , Perera Rushan , Creamer John , Macdonald Hamish , Hunter Ian 
Published: February 2017

Background: Accurate documentation in surgical operation notes is crucial in facilitating the postoperative care of surgical patients and forms an important medicolegal document. This study audited the quality and completeness of documentation in surgical operation notes at a single district general hospital against the Royal College of Surgeons (2014) Good Surgical Practice guidelines, and looked to improve clinical practice through improved compliance with these guidelines. Method: A total of 101 operation notes were audited from a variety of surgical specialities in November 2014 (cycle 1) and 100 notes in May 2015 (cycle 2). Documentation was audited against 19 standards found in the Royal College of Surgeons guidelines. The results were presented at the trust clinical governance meeting. Interventions included clinician education, aide memoires in theatres and the introduction of a new operation note. Results: Six of the 19 standards had >90% compliance in cycle 1 and 12 out of 19 in cycle 2. There were dramatic improvements in documentation in many fields including time (4% to 60%, P<0.0001), elective or emergency procedure (1% to 83%, P<0.0001), problems or complications (67% to 100%, P=0.016), estimated blood loss (2% to 73%, P<0.0001), antibiotic prophylaxis (47% to 96%, P<0.0001), venous thromboembolism prophylaxis (43% to 83%, P<0.0001) and signature (78% to 97%, P<0.0001). Conclusions: This audit has demonstrated that significant improvements in documentation in operation notes can be achieved through simple interventions. The introduction of an improved operation note that addresses each standard from the Royal College of Surgeons guidelines helped to guide clinicians to include important and relevant information.
Research in the public sphere: Connecting students & the community
Authors: Stoy Kevin , Nguyen Mai , Carden Filipe 
Published: February 2017

Despite increased pressure on academia to produce job-ready graduates, students can still learn how to discover new knowledge and put that knowledge to use without compromising the important lessons a liberal education and the interdisciplinary research process teaches. An innovative course in Mason’s Honors College called “Research in the Public Sphere” connects student researchers from across all disciplines with Northern Virginia nonprofits and businesses whose pressing challenges serve as a starting point for student research projects. Students develop their research questions around the needs of these public entities, exploring and examining their research questions from multiple perspectives. Now in its third installation, this “translational” research course demonstrates to students important relations and distinctions between “pure” and “applied” research, helping them translate their learning to the public sphere. Bio-engineering, computer science, finance, government and international politics, neuroscience, psychology, and systems engineering majors have all taken the course. Two students who took the course will share some specific research experiences and learning gains. Lesson plans will be made available for those interested in particular assignments from the course.
Digital Game Addiction Scale for Children<p>Çocuklar İçin Dijital Oyun Bağımlılığı Ölçeği
Authors: Hazar Zekihan , Hazar Muhsin , Hazar Muhsin , Hazar Muhsin 
Published: February 2017

The aim of this study is to determine the validity and reliability of the Digital Game Addiction Scale for Children. The sample group with a mean age of 12 consisted of 364 persons, 152 female (42%) and 212 male (58%). Explanatory factor analysis (AFA) and confirmatory factor analysis (DFA) were performed to ensure the validity of the scale. In the explanatory factor analysis, the items are aggregated under four factors and explain 47.953 of the total variance. The first sub-factor consists of 7th, 10th, 12th, 15th, 19th, 20th, 30th, the second sub-factor consists of 1st, 3rd, 16th, 22nd, 24th, 28th, 31st, the third sub-factor consists of 17th, 21st, 23rd, 25th, 27th, 29th, the fourth sub-factor consist of 2nd, 4th, 13th,14th items. Within the scope of item analysis, the mean scores of the sub 27% (individuals with high levels of measured characteristics) of the group and the top 27% (individuals with low levels of measured characteristics) of the group was examined by conducting independent t-test. Confirmatory factor analysis results have been found to meet standard compliance indices. The reliability of the instrument was tested by the Cronbach Alpha internal consistency coefficient and the Test-retest method. When the reliability analysis results are taken into account, it can be said that the scale is a reliable measuring tool. ÖzetBu çalışmanın amacı; “Çocuklar İçin Dijital Oyun Bağımlılığı Ölçeği” nin geçerlik ve güvenirliğini tespit etmektir. 152’si kız (%42), 212’ si erkek (%58) toplam 364 kişilik çalışma gurubunun yaş ortalaması 12’dir. Ölçeğin yapı geçerliğini sağlamak amacıyla açımlayıcı faktör analizi (AFA) ve doğrulayıcı faktör analizi (DFA) yapılmıştır. Açımlayıcı faktör analizinde maddeler dört faktör altında toplanmış ve toplam varyansın 47.953’ ünü açıklamaktadır. Birinci alt faktör 7.,10.,12.,15.,19.,20.,30., ikinci alt faktör 1.,3.,16.,22.,24.,28.,31., üçüncü alt faktör 17.,21.,23.,25.,27.,29., dördüncü alt faktör 2.,4.,13.,14., maddelerden oluşmuştur. Ölçek maddelerinin ayırt ediciliğini belirlemek amacıyla madde analizi kapsamında, toplam ölçek puanına göre belirlenen alt % 27 ve üst % 27 gruplarının ortalama puanları bağımsız t-testi yapılarak incelenmiştir. Yapılan analizlerde ölçekte yer alan maddelerin alt-üst grupların ayırt edilmesinde oldukça güvenilir sonuçlar verdiği söylenebilir. Doğrulayıcı faktör analizi sonuçlarının standart uyum indekslerini karşıladığı sonucuna varılmıştır. Ölçme aracının güvenirliği, Cronbach Alfa iç tutarlık katsayısı ve Test-tekrar test yöntemi ile test edilmiştir. Sonuç olarak, yapılan analizler, “ÇİDOBÖ’ nün çocukların dijital oyun bağımlılık durumunu ölçme ve değerlendirmede geçerli ve güvenilir bir ölçek olduğunu ortaya koymuştur.
El árbol de Adán, de Gerardo Guinea Diez. Narrativa y memoria del genocidio guatemalteco (El árbol de Adán, by Gerardo Guinea Diez. Narrative and Remembrance of the Genocide in Guatemala)
Authors: López Martínez María Del Pilar 
Published: February 2017

El estudio analiza la propuesta estética de una de las novelas menos estudiadas sobre el genocidio guatemalteco: El árbol de Adán. Se efectúa un recorrido sobre la obra de ficción del escritor Gerardo Guinea Diez, e incursiona en algunos elementos de su poética para señalar las diferencias con la llamada «literatura de posguerra centroamericana», así como con el modelo predominante que entre los historiadores literarios se tiene. Muestra esos otros imaginarios que desde el interior de los países centroamericanos se construyen, muchas veces a contrapelo de lo que se conoce desde fuera de las fronteras del Istmo.This study analyzes the aesthetic proposal of one of the least known novels about the Guatemalan genocide: El Árbol de Adán (Adam’s Tree). It explores the fictional works of Gerardo Guinea Diez, and addresses the author’s poetic style, to emphasize the discrepancies between his work and that of the so-called “post-war school of Central American literature” and the predominant model supported by historians. The article reveals these other imaginary worlds created from within the Central American countries, but which often contrast with widespread perceptions of those who are outside the region.
Pediatric Exposures to Veterinary Pharmaceuticals
Authors: Tomasi Suzanne , Roberts Kristin J. , Stull Jason , Spiller Henry A. , McKenzie Lara B. 
Published: February 2017

OBJECTIVE:
To describe the epidemiology of veterinary pharmaceutical-related exposures to children based on calls to a regional poison control center.

METHODS:
A retrospective analysis of pediatric (≤19 years of age) exposures to pharmaceutical products intended for animal use, managed by a regional poison control center from 1999 through 2013, was conducted. Case narratives were reviewed and coded for exposure-related circumstances and intended species. Descriptive statistics were generated.

RESULTS:
From 1999 through 2013, the Central Ohio Poison Center received 1431 calls that related to a veterinary pharmaceutical exposure for children ≤19 years of age. Most of the pediatric calls (87.6%) involved children ≤5 years of age. Exploratory behavior was the most common exposure-related circumstance (61.4%) and ingestion accounted for the exposure route in 93% of cases. Substances commonly associated with exposures included: veterinary drugs without human equivalent (17.3%), antimicrobial agents (14.8%), and antiparasitics (14.6%). Based on substance and quantity, the majority of exposures (96.9%) were not expected to result in long-term or lasting health effects and were managed at home (94.1%). A total of 80 cases (5.6%) were referred to a health care facility, and 2 cases resulted in a moderate health effect.

CONCLUSIONS:
Children ≤5 years of age are most at risk for veterinary pharmaceutical-related exposures. Although most exposures do not result in a serious medical outcome, efforts to increase public awareness, appropriate product dispensing procedures, and attention to home storage practices may reduce the risk of veterinary pharmaceutical exposures to young children.
E-Cigarettes and “Dripping” Among High-School Youth
Authors: Krishnan-Sarin Suchitra , Morean Meghan , Kong Grace , Bold Krysten W. , Camenga Deepa R. , Cavallo Dana A. , Simon Patricia , Wu Ran 
Published: February 2017

BACKGROUND:
Electronic cigarettes (e-cigarettes) electrically heat and vaporize e-liquids to produce inhalable vapors. These devices are being used to inhale vapors produced by dripping e-liquids directly onto heated atomizers. The current study conducts the first evaluation of the prevalence rates and reasons for using e-cigarettes for dripping among high school students.

METHODS:
In the spring of 2015, students from 8 Connecticut high schools (n = 7045) completed anonymous surveys that examined tobacco use behaviors and perceptions. We assessed prevalence rates of ever using e-cigarettes for dripping, reasons for dripping, and predictors of dripping behaviors among those who reported ever use of e-cigarettes.

RESULTS:
Among 1080 ever e-cigarette users, 26.1% of students reported ever using e-cigarettes for dripping. Reasons for dripping included produced thicker clouds of vapor (63.5%), made flavors taste better (38.7%), produced a stronger throat hit (27.7%), curiosity (21.6%), and other (7.5%). Logistic regression analyses indicated that male adolescents (odds ratio [OR] = 1.64), whites (OR = 1.46), and those who had tried multiple tobacco products (OR = 1.34) and had greater past-month e-cigarette use frequency (OR = 1.07) were more likely to use dripping (Ps &lt; .05).

CONCLUSIONS:
These findings indicate that a substantial portion (∼1 in 4) of high school adolescents who had ever used e-cigarettes also report using the device for dripping. Future efforts must examine the progression and toxicity of the use of e-cigarettes for dripping among youth and educate them about the potential dangers of these behaviors.
BEBERAPAASPEKBIOLOGI CUMI-CUMI JAMAK(Loligo duvaucelli) YANGDIDARATKAN DI BLANAKAN, SUBANG, JAWABARAT
Authors: Chodrijah Umi , Budiarti Tri Wahyu 
Published: February 2017

Cumi-cumi (Loligo sp.) merupakan salah satu sumber daya hayati laut yang memiliki nilai ekonomis penting dan mengandung nilai gizi tinggi dengan cita rasa yang khas. Pengamatan terhadap beberapa aspek biologi cumi-cumi jamak (Loligo duvaucelli) telah dilakukan pada bulan Juni 2005 sampai Nopember 2006 di Pusat Pendaratan Ikan Blanakan, Kabupaten Subang, Jawa Barat. Penelitian ini bertujuan untuk mengetahui sebaran panjang mantel, nisbah kelamin, komposisi makanan, serta hubungan panjang mantel dan bobot cumi-cumi jamak. Pengukuran karakter biologi meliputi panjang mantel (ML), bobot tubuh (W), dan isi perut. Hasil penelitian ini menunjukkansebaran panjang mantel cumi-cumi yang tertangkap berkisar antara 3,0-36,0 cm dengan modus 15 cm dan panjang mantel rata-rata 13,3 cm. Nisbah kelamin cumi-cumi pada bulanApril dan Juni 2006 dalamkeadaan tidak seimbang. Pola pertumbuhan cumi-cumi baik jantanmaupun betina bersifat alometrik negatif. Cumi-cumi merupakan karnivora yang makanan utamanya adalah ikan-ikan kecil. The squid is one of living marine resources that have important economic value and conyain high nutrional value with a distinctive taste. Observation on the biological aspect of squid jamak) was performed in June 2005 to November 2006 in Blanakan, Subang,West Java. This study aims to determine the distribution of mantle length, sex ratio, food composition, and the relationship mantle and weight of squid. Measurement of biological characters include mantle length (ML), body weight (W), and stomach contents. The results showed that the distribution of squid mantle length capture at Blanakan, ranges from 3.0-36.0 cm with a mode at 15 cm and an average mantlelength of 13.3 cm. The squid sex ratio in April and June 2006 in a state of imbalance. The growth rate of the squid both males and females are allometric negative. The squid is a carnivorous diet is primarily small fish.
KEANEKARAGAMANPLANKTONDANTINGKATKESUBURANPERAIRAN DIWADUKGAJAHMUNGKUR
Authors: Utomo Agus Djoko , Ridho Mohamad Rasyid , Putranto DinarDA , Saleh Edward 
Published: February 2017

Perairan Waduk Gajah Mungkur merupakan tipe perairan yang tergenang mempunyai dan arti penting bagi perikanan. Plankton di perairanWadukmempunyai peranan bagi sumberdaya perikanan, antara lain sebagai produsen primer dan dapat dijadikan sebagai indikator kualitas lingkungan perairan. Kelimpahan plankton di suatu perairan dipengaruhi oleh parameter lingkungan perairan. Penelitian ini bertujuan untukmengetahui tingkat kesuburan perairan, kelimpahan dan keanekaragaman plankton Penelitian dilakukan bulan Pebruari - Nopember 2010 dengan frekuensi pengambilan contoh sebanyak empat kali yaitu pada bulan Pebruari, Mei, Juli dan Nopember. Analisis tingkat kesuburan perairan dengan metode Carlon’s dapat diketahui perairan Waduk Gajah Mungkur termasuk katagori perairan dengan tingkat kesuburannya tinggi.Waduk GajahMungkur termasuk perairan dengan kelimpahan plankton tinggi dan keanekaragaman plankton rendah yang didominansi oleh Synedra ulna Gajah Mungkur reservoir is a lentic water and has significance impact for fishery. Plankton in the reservoir as the primary producer has an important role on fisheries, could be used as an indicator of aquatic environmental quality. Abundance of plankton will be influenced by environmental condition including water quality. The purpose of this study to determine the productivity level of water quality, abundance and diversity of plankton. The study was conducted from February to November 2010, with schedule of sampling was in February, May, July and November 2010. Based on analysis by Carlon’s method, the results showed that the water quality at Gajah Mungkur reservoirwas eutrophic level. Gajah Mungkur reservoir has high plankton abundance and low plankton diversity the species of plankton was dominated by Synedra ulna.
KAJIAN KETERKAITAN ANTARA CADANGAN OKSIGEN DENGAN BEBAN BAHAN ORGANIK DI ZONA LAKUSTRIN DAN TRANSISI WADUK IR. H. DJUANDA
Authors: Simarmata Asmika H. , Adiwilaga Enan M. , Lay Bibiana W. , Prartono Tri 
Published: February 2017

Kematian massal ikan pada budi daya ikan dalam karamba jaring apung di Waduk Ir. H. Djuanda hampir selalu terjadi setiap tahun. Deplesi oksigen merupakan faktor yang mempengaruhi kondisi tersebut. Oleh karena itu, penelitian ini dilakukan. Tujuan penelitian ini adalah untuk mengkaji atau menentukan kemampuan perairan dalam menerima beban bahan organik. Penelitian dilakukan di Waduk Ir. H. Djuanda dari bulan Juni 2003 sampai dengan Mei 2004, dengan interval pengambilan contoh setiap bulan. Pengambilan contoh dilakukan di wilayah lakustrin yaitu stasiun L1, L2, dan L3 dan wilayah transisi stasiun T1, T2, dan T3. Pengambilan contoh vertikal meliputi permukaan, kedalaman 7, 15, 25, dan 35 m, dan dasar perairan. Metode dalam penelitian ini adalah survei post fakto. Analisis contoh dilakukan di laboratorium produktivitas perairan, Fakultas Perikanan dan Ilmu Kelautan, Institut Pertanian Bogor dan laboratorium kimia Loka Riset Pemacuan Stok Ikan, Jatiluhur. Parameter yang dianalisis adalah oksigen terlarut, bahan organik total, dan K2 (koefisien peluruhan), sedangkan parameter penunjang adalah suhu dan H2S. Hasil penelitian ini menunjukkan bahwa peningkatan bahan organik menyebabkan deplesi oksigen semakin tajam pada musim hujan di wilayah lakustrin. Konsentrasi bahan organik yang aman adalah 7,76 mg per l. Mass mortality of fishes at Ir. H. Djuanda Reservoir occurs almost every year. Oxygen depletion is one factor that affect the condition. There fore, this research should be done. The carrying capacity at Ir. H. Djuanda Reservoir to receive organic loading were determined in this study. The research conducted at Ir. H. Djuanda Reservoir from June 2003 until May 2004. Horizontal sampling station was conducted based on longitudinal gradient i.e. lacustrine zone (L1, L2, and L3), and transition zone (T1, T2, and T3). Vertical sampling points were at surface, at the depth of 7 m, 15, 25, 35, and 45 m, and at the bottom. Sample analysis carried out in physical chemical laboratory of Aquatic Resources Management Department, Faculty of Fisheries and Marine Science, IPB and chemical laboratory Loka Jatiluhur. The methods of this research were post facto survey descriptive. Dissolved oxygen, total organic matter, and BOD were observed during research.temperature and H2S were observed to support the study. The results showed that the increasing of organic matter cause the steep of oxygen depletion in transition of wet season at lacustrine zone. Acceptable concentration of total organic matter was 7.76 mg per l.