bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells
Authors: de Witte Samantha F.H. , Luk Franka , Sierra Parraga Jesus M. , Gargesha Madhu , Merino Ana , Korevaar Sander S. , Shankar Anusha S. , O'Flynn Lisa , Elliman Steve J. , Roy Debashish , Betjes Michiel G.H. , Newsome Philip N. , Baan Carla C. , Hoogduijn Martin J. 
Published: January 2018

Abstract
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential immunotherapy. MSC are usually administered via intravenous infusion, after which they are trapped in the lungs and die and disappear within a day. The fate of MSC after their disappearance from the lungs is unknown and it is unclear how MSC realize their immunomodulatory effects in their short lifespan. We examined immunological mechanisms determining the fate of infused MSC and the immunomodulatory response associated with it. Tracking viable and dead human umbilical cord MSC (ucMSC) in mice using Qtracker beads (contained in viable cells) and Hoechst33342 (staining all cells) revealed that viable ucMSC were present in the lungs immediately after infusion. Twenty-four hours later, the majority of ucMSC were dead and found in the lungs and liver where they were contained in monocytic cells of predominantly non-classical Ly6Clow phenotype. Monocytes containing ucMSC were also detected systemically. In vitro experiments confirmed that human CD14++/CD16- classical monocytes polarized toward a non-classical CD14++CD16+CD206+ phenotype after phagocytosis of ucMSC and expressed programmed death ligand-1 and IL-10, while TNF-α was reduced. ucMSC-primed monocytes induced Foxp3+ regulatory T cell formation in mixed lymphocyte reactions. These results demonstrate that infused MSC are rapidly phagocytosed by monocytes, which subsequently migrate from the lungs to other body sites. Phagocytosis of ucMSC induces phenotypical and functional changes in monocytes, which subsequently modulate cells of the adaptive immune system. It can be concluded that monocytes play a crucial role in mediating, distributing, and transferring the immunomodulatory effect of MSC.
Characterisation and modelling of in-plane springback in a commercially pure titanium (CP-Ti)
Authors: Khayatzadeh S. , Thomas M. J. , Millet Y. , Rahimi S. 
Published: January 2018

AbstractEffective prediction of springback during sheet metal forming is critically important for automotive and aerospace industries, especially when forming metals with high strength-to-weight ratio such as titanium. This requires materials mechanical data during plastic deformation and their dependencies on parameters like strain, strain rate and sample orientation. In this study, springback is quantified experimentally as elastic strain recovery, degradation in Young’s modulus and inelastic strain recovery on unloading in a commercially pure titanium type 50A (CP-Ti-50A). The results show strain rate-dependent anisotropic mechanical behaviours and a degradation in Young’s modulus with increased level of plastic deformation. The level of degradation in Young’s modules increases gradually from 13% for samples parallel to the rolling direction (RD) to 20% for those perpendicular to the RD. A measurable nonlinear strain recovery was also observed on unloading that is orientation dependent. The level of springback is characterised as the sum of elastic recovery and the contributions from both the degradation in Young’s modulus and anelastic strain recovery. It is shown that the Chord modulus can estimate springback with a reasonable accuracy taking into consideration the elastic strain recovery, degradation in Young’s modulus and anelastic strain recovery.
Ginsenoside improves papillary thyroid cancer cell malignancies partially through upregulating connexin 31
Authors: Xu Li , Chen Su‐Wan , Qi Xiao‐Yan , Li Xin‐Xin , Sun Yuan‐Bo 
Published: January 2018

AbstractConnexin 31 (Cx31) is considered a suppressor for many tumors. Ginsenoside (Rg1) is a traditional Chinese herb that is widely acknowledged due to its anti‐tumor characteristics. However, limited studies have focused on the role of Rg1 in papillary thyroid cancer (PTC) cells. In the current study, we found that the expression of Cx31 in thyroid cancer tissues and thyroid cancer cell lines was significantly lower than that in normal thyroid epithelial tissues and cell lines. Overexpression of Cx31 reduced thyroid cancer cell proliferation, migration and invasion. Furthermore, we found that Rg1 significantly enhanced the expression of Cx31. Moreover, the proliferation and migration of IHH‐4 and BCPAP cells were significantly reduced by Rg1 treatment. In contrast, the silencing of Cx31 enhanced the expression of Ki67 and proliferating cell nuclear antigen (PCNA). Meanwhile, treatment with Rg1 significantly decreased the protein levels of Ki67 and PCNA, but these effects could be abolished by transfection with si‐Cx31. In summary, we provide novel evidence that the expression of Cx31 was decreased in thyroid cancer cells, but Rg1 treatment could significantly enhance the expression of Cx31 thereby suppressing thyroid cancer cell proliferation and migration.
A Mistake in the Commodification Debate
Authors: SEMRAU LUKE 
Published: January 2018

ABSTRACT:A significant debate has developed around the question: What are the moral limits of the market? This paper argues that this debate proceeds on a mistake. Both those who oppose specific markets and those who defend them, adopt the same deficient approach. Participants illicitly proceed from an assessment of the transactions making up a market to a judgment of that market's permissibility. This inference is unlicensed. We may know everything there is to know about the transactions in a specific market—they might all be absolutely bad—but we will not yet know whether that market should be prohibited. To discern this, to establish that intervention into some specific market is justifiable, one must supply a rather different assessment. One must compare the outcome in which that market is permitted with the best outcome available in its absence. None in this debate has offered such a judgment.
Effects of krill oil and lean and fatty fish on cardiovascular risk markers: a randomised controlled trial
Authors: Rundblad Amanda , Holven Kirsten B. , Bruheim Inge , Myhrstad Mari C. , Ulven Stine M. 
Published: January 2018

AbstractFish consumption and supplementation with n-3 fatty acids reduce CVD risk. Krill oil is an alternative source of marine n-3 fatty acids and few studies have investigated its health effects. Thus, we compared krill oil supplementation with the intake of fish with similar amounts of n-3 fatty acids on different cardiovascular risk markers. In an 8-week randomised parallel study, thirty-six healthy subjects aged 18–70 years with fasting serum TAG between 1·3 and 4·0 mmol/l were randomised to receive either fish, krill oil or control oil. In the fish group, subjects consumed lean and fatty fish, according to dietary guidelines. The krill and control group received eight capsules per d containing 4 g oil per d. The weekly intake of marine n-3 fatty acids from fish given in the fish group and from krill oil in the krill group were 4103 and 4654 mg, respectively. Fasting serum TAG did not change between the groups. The level of total lipids (P = 0·007), phospholipids (P = 0·015), cholesterol (P = 0·009), cholesteryl esters (P = 0·022) and non-esterified cholesterol (P = 0·002) in the smallest VLDL subclass increased significantly in response to krill oil supplementation. Blood glucose decreased significantly (P = 0·024) in the krill group and vitamin D increased significantly in the fish group (P = 0·024). Furthermore, plasma levels of marine n-3 fatty acids increased significantly in the fish and krill groups compared with the control (all P ≤ 0·0003). In conclusion, supplementation with krill oil and intake of fish result in health-beneficial effects. Although only krill oil reduced fasting glucose, fish provide health-beneficial nutrients, including vitamin D.
Statistical evidence on the effect of production changes on induced seismicity
Authors: Sijacic Danijela , Pijpers Frank , Nepveu Manuel , van Thienen-Visser Karin 
Published: January 2018

AbstractDepletion of the Groningen gas field has induced earthquakes, although the north of the Netherlands is a tectonically inactive region. Increased seismic activity raised public concern which led the government to initiate a number of studies with the aim of understanding the cause(s) of the earthquakes. If the relationship between production and seismicity were understood then production could be optimized in such a way that the risk of induced seismicity would be minimal. The main question remains how production is correlated with induced seismicity. The Minister of Economic Affairs of the Netherlands decided to reduce production starting from 17 January 2014, specifically in the centre of the gas field as it has the highest rates of seismicity, the largest-magnitude events and the highest compaction values of the field.A reduction in production could possibly lead to a reduced rate of compaction. Additionally a reduction of production rate could lead to a reduced stress rate increase on the existing faults and consequently fewer seismic events per year. One might envisage a ‘bonus effect’ in the events reduction in the sense that the total number of events will be less, with the same total production smeared out over a longer period. This is as yet unclear.In this paper we apply different statistical methods to look for evidence supporting or disproving a decrease in the number of seismic events due to production reduction.
From checking deterministic predictions to probabilities, scenarios and control loops for regulatory supervision
Authors: de Waal J.A. , Muntendam-Bos A.G. , Roest J.P.A. 
Published: January 2018

AbstractPrediction of gas-production-induced subsidence and seismicity is much more difficult and uncertain than generally recognised in the past. It is now widely accepted that uncertainties in predicted subsidence and seismicity are large prior to and during the initial stages of production. At later stages, predictions remain highly uncertain for periods more than three to five years into the future. This requires a different regulatory framework to ensure that associated risks remain within accepted boundaries. Previously, single-scenario operator predictions were checked against field measurements. When subsidence or seismicity started to deviate beyond claimed uncertainties, the operator was asked to provide prediction updates. The practice was long considered acceptable, as structural damage to buildings and infrastructure or personal risk to people was not expected. This all changed following the 2012 Huizinge seismic event, necessitating better identification, assessment and ranking of risks, the use of scenarios, probabilistic forecasting and a much intensified field monitoring and control loop. It requires that the regulator becomes actively involved in assuring the integrated control loop of risk identification, predictions, monitoring, updating, mitigation measures and the closing of knowledge gaps, to ensure that subsidence (rate) and induced seismicity remain within acceptable limits. And it requires that this increased involvement of the regulator is supported in the mining law and by appropriate conditions in the Production Plan assent.
The effect of salt in dilatant faults on rates and magnitudes of induced seismicity – first results building on the geological setting of the Groningen Rotliegend reservoirs
Authors: Kettermann Michael , Abe Steffen , Raith Alexander F. , de Jager Jan , Urai Janos L. 
Published: January 2018

AbstractThe presence of salt in dilatant normal faults may have a strong influence on fault mechanics in the Groningen field and on the related induced seismicity. At present, little is known of the structure of these fault zones. This study starts with the geological evolution of the Groningen area, where, during tectonic faulting, rock salt may have migrated downwards into dilatant faults. These fault zones therefore may contain inclusions of rock salt. Because of its rate-dependent mechanical properties, the presence of salt in a fault may introduce a loading-rate dependency into fault movement and affect the distribution of magnitudes of seismic events. We present a first-look study showing how these processes can be investigated using a combination of analogue and numerical modelling. Full scaling of the models and quantification of implications for induced seismicity in Groningen require further, more detailed studies: an understanding of fault zone structure in the Groningen field is required for improved predictions of induced seismicity. The analogue experiments are based on a simplified stratigraphy of the Groningen area, where it is generally thought that most of the Rotliegend faulting has taken place in the Jurassic, after deposition of the Zechstein. This suggests that, at the time of faulting, the sulphates were already transformed into brittle anhydrite. If these layers were sufficiently brittle to fault in a dilatant fashion, rock salt was able to flow downwards into the dilatant fractures. To test this hypothesis, we use sandbox experiments where we combine cohesive powder as analogue for brittle anhydrites and carbonates with viscous salt analogues to explore the developing fault geometry and the resulting distribution of salt in the faults. Using the observations from analogue models as input, numerical models investigate the stick-slip behaviour of fault zones containing ductile material qualitatively with the discrete element method (DEM). Results show that the DEM approach is suitable for modelling the seismicity of faults containing salt. The stick-slip motion of the fault becomes dependent on shear loading rate with a modification of the frequency–magnitude distribution of the generated seismic events.
Research into induced seismicity in the Groningen field – further studies
Authors: Jansen Jan-Dirk , Herber Rien 
Published: January 2018

AbstractFurther research into seismicity caused by natural gas production from the Groningen field is necessary to improve the assessment of seismic risk and develop means to control and reduce it. Research into subsurface aspects is primarily of relevance to assess the seismic hazard component in the cause-and-effect chain that governs the seismic risk. It requires a wide range of research activities that can be broadly classified as follows:
•Increasing understanding of the physical mechanisms that govern production-induced seismicity, in particular source mechanisms, compaction behaviour, propagation of energy to the surface, and the effects of fluctuating production.•Reducing uncertainty by acquiring additional field data to improve statistical inference, and developing statistical methods and procedures that can cope with the non-stationary nature of the process.•Developing tools and techniques to improve risk management, and support operational control and policy measures under uncertainty.An essential requirement for further research will be the possibility of developing competing theories for many aspects of the modelling chain. This requires an overall hazard and risk assessment methodology that can accommodate multiple models, and an organisational structure that facilitates the comparison of competing approaches while safeguarding their independent development. This will have to be supported by the availability of reliable data via shared databases. Finally, the scientific community should be prepared to make a major effort to translate their research results into popular scientific versions in order to keep stakeholders abreast of progressive insight into the origin, predictability and prevention of induced seismicity.
New approaches in experimental research on rock and fault behaviour in the Groningen gas field
Authors: Spiers Christopher J. , Hangx Suzanne J.T. , Niemeijer André R. 
Published: January 2018

AbstractThis paper describes a research programme recently initiated at Utrecht University that aims to contribute new, fundamental physical understanding and quantitative descriptions of rock and fault behaviour needed to advance understanding of reservoir compaction and fault behaviour in the context of induced seismicity and subsidence in the Groningen gas field. The NAM-funded programme involves experimental rock and fault mechanics work, microscale observational studies to determine the processes that control reservoir rock deformation and fault slip, modelling and experimental work aimed at establishing upscaling rules between laboratory and field scales, and geomechanical modelling of fault rupture and earthquake generation at the reservoir scale. Here, we focus on describing the programme and its intended contribution to understanding the response of the Groningen field to gas production. The key knowledge gaps that drive the programme are discussed and the approaches employed to address them are highlighted. Some of the first results emerging from the work in progress are also reported briefly and are providing important new insights.
How immediate and significant is the outcome of training on diversified diets, hygiene and food safety? An effort to mitigate child undernutrition in rural Malawi
Authors: Seetha Anitha , Tsusaka Takuji W , Munthali Timalizge W , Musukwa Maggie , Mwangwela Agnes , Kalumikiza Zione , Manani Tinna , Kachulu Lizzie , Kumwenda Nelson , Musoke Mike , Okori Patrick 
Published: January 2018

AbstractObjectiveThe present study examined the impacts of training on nutrition, hygiene and food safety designed by the Nutrition Working Group, Child Survival Collaborations and Resources Group (CORE).DesignAdapted from the 21d Positive Deviance/Hearth model, mothers were trained on the subjects of appropriate complementary feeding, water, sanitation and hygiene (WASH) practices, and aflatoxin contamination in food. To assess the impacts on child undernutrition, a randomised controlled trial was implemented on a sample of 179 mothers and their children (<2 years old) in two districts of Malawi, namely Mzimba and Balaka.SettingsA 21d intensive learning-by-doing process using the positive deviance approach.SubjectsMalawian children and mothers.ResultsDifference-in-difference panel regression analysis revealed that the impacts of the comprehensive training were positive and statistically significant on the Z-scores for wasting and underweight, where the effects increased constantly over time within the 21d time frame. As for stunting, the coefficients were not statistically significant during the 21d programme, although the level of significance started increasing in 2 weeks, indicating that stunting should also be alleviated in a slightly longer time horizon.ConclusionsThe study clearly suggests that comprehensive training immediately guides mothers into improved dietary and hygiene practices, and that improved practices take immediate and progressive effects in ameliorating children’s undernutrition.
Transformation of the Japanese State in Antimonopoly Regulation after the 1980s
Authors: MOGAKI MASAHIRO 
Published: January 2018

AbstractAlthough state transformation after the 1980s has been a major topic of debate in political science, the transformation of the Japanese state has not been fully explored, with the pluralist and rational choice approaches dominating within the Japanese politics literature. This article addresses the lacuna by exploring state transformation in Japan's antimonopoly regulation after the 1980s, focusing on the state at the macro level through analysing evolving power relations within the core executive in response to the challenges of governance. The case study reveals the flexible change of power relations within the core executive; the core executive retained its dominance within policy-making arenas through this adaptation, which is regarded as the reconstitution of the state. Drawing on that, the article argues that the nature of state transformation in Japan is the sustained dominance of the core executive as a collective group over the sector through reconstituting the state.
Glimmers of hope: A report on the Philippine Criminal Justice System
Authors: Valenzuela Roy Panti 
Published: January 2018

AbstractThere is a saying: “Justice delayed is justice denied.” The perception of a continuing failure of the Philippine criminal justice system to deliver fast and efficient justice has inevitably led to the erosion of public trust in the government. As a consequence, citizens are laden with anxiety because of unabated criminality and violence in their communities. The type of justice that leads to peace and prosperity continues to be elusive in the Philippines as the worsening scenario of jail congestion continues to manifest its malevolent implications for the human rights of prisoners. It appears that the culprit is an overwhelmed machinery of criminal justice that has not been able to keep pace with growing rates of population, urbanization and criminality. There is also an apparent imbalance in the justice structure where there are too few judges, prosecutors and public defence attorneys to process the cases filed by the numerous law enforcers who file criminal cases. This leads to bottlenecks in criminal justice procedures and has resulted, in not a few instances, in human rights crises in jails. However, emerging developments give some hope to Filipinos.
Virtual craniotomy for high-resolution optoacoustic brain microscopy
Authors: Estrada Héctor , Huang Xiao , Rebling Johannes , Zwack Michael , Gottschalk Sven , Razansky Daniel 
Published: January 2018

AbstractUltrasound-mediated transcranial images of the brain often suffer from acoustic distortions produced by the skull bone. In high-resolution optoacoustic microscopy, the skull-induced acoustic aberrations are known to impair image resolution and contrast, further skewing the location and intensity of the different absorbing structures. We present a virtual craniotomy deconvolution algorithm based on an ultrasound wave propagation model that corrects for the skull-induced distortions in optically-resolved optoacoustic transcranial microscopy data. The method takes advantage of the geometrical and spectral information of a pulse-echo ultrasound image of the skull simultaneously acquired by our multimodal imaging system. Transcranial mouse brain imaging experiments confirmed the ability to accurately account for the signal amplitude decay, temporal delay and pulse broadening introduced by the rodent’s skull. Our study is the first to demonstrate skull-corrected transcranial optoacoustic imaging in vivo.