bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequent sleep‐related bitemporal focal seizures in transient epileptic amnesia syndrome: Evidence from ictal video‐EEG
Authors: Burkholder David B. , Jones Amy L. , Jones David T. , Fabris Rachel R. , Britton Jeffrey W. , Lagerlund Terrence D. , So Elson L. , Cascino Gregory D. , Worrell Gregory A. , Shin Cheolsu , St. Louis Erik K. 
Published: January 2017

SummaryTwo patients who shared similar presenting clinical features of anterograde and retrograde autobiographical amnesia typical of transient epileptic amnesia (TEA) underwent prolonged video electroencephalogram (VEEG) monitoring and were found to have sleep‐activated epileptiform activity and frequent subclinical bitemporal seizures predominantly during sleep. Case 1 is a 59‐year‐old woman whose presenting complaint was memory impairment. Over 18 months, she had three distinct 8‐h‐long episodes of confusion and disorientation with persistent anterograde and retrograde autobiographical amnesia. VEEG recorded frequent interictal bitemporal sharp waves confined to sleep, and 14 subclinical seizures, also mostly during sleep. Case 2 is a 50‐year‐old woman with known focal epilepsy also presented with memory complaints. Over the course of 1 year, she had two discrete 2‐h‐long episodes of amnesia, with ongoing anterograde and retrograde autobiographical amnesia. VEEG recorded independent bitemporal sharp waves, and 14 subclinical seizures during sleep and drowsiness. Memory impairment improved in both patients with successful treatment of their seizures. Although the etiology of accelerated long‐term forgetting (ALF) and remote memory impairment (RMI) in transient epileptic amnesia (TEA) is unknown, these cases suggest frequent sleep‐related seizures may contribute, and they highlight the importance of video‐EEG monitoring.
Hereditary angioedema with normal C1 inhibitor in a French cohort: Clinical characteristics and response to treatment with icatibant
Authors: Bouillet Laurence , Boccon‐Gibod Isabelle , Launay David , Gompel Anne , Kanny Gisele , Fabien Vincent , Fain Oliver ,   for the IOS Study Group
Published: January 2017

AbstractIntroductionThe clinical characteristics and icatibant‐treatment outcomes of patients with hereditary angioedema with normal C1 inhibitor (HAE‐nC1 INH) are limited.MethodsWe retrospectively analyzed data from French HAE patients enrolled in the Icatibant Outcome Survey registry (from July 2009 to September 2013) to compare disease characteristics and the effectiveness and safety of acute icatibant‐treated angioedema attacks in patients with HAE‐nC1 INH, HAE with C1 INH deficiency (type I), or dysfunction (type II).ResultsOne center in Grenoble contributed 22 patients with HAE‐nC1 INH and a family history of HAE while 15 centers across France contributed 153 patients with HAE type I and seven patients with HAE type II. Patients with HAE‐nC1 INH compared to HAE type I, respectively, were more likely to be female (88.1% vs. 63.4%), older at median age of disease onset (21 years vs. 15 years), and have a greater rate of abdominal (80% vs. 61%) and laryngeal (23% vs. 14%) attacks. Icatibant was effective in both groups though the median time to resolution of attack was significantly longer in the HAE‐nC1 INH group (20.0 h, 37 attacks) versus the HAE type I group (14.0 h, 67 attacks). Icatibant was self‐administered for 96.1% of attacks in patients with HAE‐nC1 INH and 75.8% in patients with HAE type I. No serious adverse side effects related to icatibant were reported.ConclusionsThese data help further define the disease characteristics of HAE‐nC1 INH in the French population and extend the limited data reporting the safe and effective use of icatibant in acute treatment of angioedema in French patients diagnosed with HAE‐nC1 INH.
A New Look at the Etiology of Cervical Incompetence
Authors: Nwosu Uchenna C. , Soffronoff Ernest C. , Bolton Gregory C. 
Published: January 2017

Nwosu, C. U., Soffronoff, E. C. and Bolton, G. C. (Dept. of Obstetrics & Gynecology, Pennsylvania Hospital, University of Pennsylvania School of Medicine, Philadelphia, Pa.) A new look at the etiology of cervical incompetence, with review of seven‐year experience at Pennsylvania Hospital.Int J Gynaecol Obstet 13: 201–205, 1975.A review of our seven‐year experience with cervical cerclage is presented. A rising frequency is noted which cannot be explained by an increasing rate of abortions over the same period. The population with this entity showed a strikingly poor obstetrical outcome of their first pregnancy. The neonatal survival rate of the 125 pregnancies in this group prior to cerclage was 25% as compared with 71% in the 52 cerclage pregnancies. It is proposed that gestational incompetence may be initiated by hormonally induced relaxation of a congenially hypermuscular cervix.
Primary Ovarian Pregnancy: Report of Two Cases: Management with Ovarian Preservation
Authors: Gogol Gideon , Gheorghiou Panayotis , Grünstein Stephan , Pevzner Shamai 
Published: January 2017

ABSTRACTGogol, G., Gheorghiou, P., Grünstein, S. and Pevzner, Sh. (Dept. of Obstetrics and Gynecology, Hillel Yaffe Memorial Hospital, Hadera, Israel).
Minilaparotomy for Female Sterilization: A Feasibility Study of a New Technique
Authors: Hefnawi F. , Badraoui M. H. H. , Serour G. I. 
Published: January 2017

Hefnawi, F., Badraoui, M. H. H. and Serour, G. I. (Dept. of Obstetrics and Gynaecology, Al‐Azhar University Teaching Hospital, Cairo, Egypt). Minilaparotomy for female sterilization: A feasibility study of a new technique.Int J Gynaecol Obstet 14: 390–392, 1976.Female sterilization via a minilaparotomy incision was performed on 30 patients at Al‐Azhar University Teaching Hospital in Cairo, Egypt. A uterine sound fed through a Foley catheter was used as a uterine elevator. A 2 cm suprapubic transverse laparotomy was performed and sterilization was accomplished by fimbriectomy. Twenty patients received general anesthesia and 10 patients initially received local anesthesia. Surgical time ranged from 7 to 15 min, and the average duration of hospitalization was 8 hours. Blood loss was small, and no patient was transfused. One patient had a wound infection. This pilot study indicates that this procedure is relatively simple, safe and inexpensive.
Ossification Centers as Evidence of Fetal Lung Maturity
Authors: Weiss David B. , Aboulafia Yeshaya , Eylath Uri , Isacshon Meir , Dollberg Marcel 
Published: January 2017

Weiss, D. B., Aboulafia, Y., Eylath, U., Isacshon, M. and Dollberg, M. (Dept. of Obstetrics and Gynecology, Endocrinology, Pediatrics and Radiology, Shaare Zedek Medical Center, Jerusalem 91000, Israel). Ossification centers as evidence of fetal lung maturity.Int J Gynaecol Obstet 14: 425–427, 1976.Fetal pulmonary maturity based on visualization of one or both fetal knee secondary centers of ossification was assessed in 84 gravidas. Amniotic fluid lecithin/sphingomyelin ratio of 2: 1 or greater was the criterion of fetal lung maturity. It was concluded that when antenatal radiographs reveal the presence of both centers of ossification, fetal lung maturity can be assured in 100% of the fetuses. When the distal femoral center alone is seen, only 60% of the fetuses will have mature lungs.
Fetal Heart Rate Response to Maternal Hypotension during Amniocentesis
Authors: Ron Moshe , Yaffe Haim , Polishuk Wolf Z. 
Published: January 2017

Ron, M., Yaffe, H. and Polishuk, W. Z. (Dept. of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel). Fetal heart rate response to maternal hypotension during amniocentesis.Int J Gynaecol Obstet 14:503–504, 1976.Ten cases of severe fetal heart rate deceleration following maternal vaso‐vagal reflex during amniocentesis were presented. The good outcome of these fetuses suggests that this transient phenomenon has no adverse effect on the fetus. This type of FHR response should be recognized so as to avoid unnecessary Caesarian sections done because of severe FHR bradycardia following amniocentesis.
Uterine Rupture and Vacuum Extraction
Authors: Fahmy Kamal 
Published: January 2017

Fahmy, K. (Dept. of Gynecology and Obstetrics, Maternity Hospital, Kuwait). Uterine rupture and vacuum extraction.Int J Gynaecol Obstet 14: 509–512, 1976.Eleven uterine ruptures occurred among 11415 vacuum extractions, and these cases are analysed. Cervical tears extending into the lower uterine segment or into the broad ligament occurred in 4 cases, lower segment tears in 6 and a fundal tear in 1. One patient died of respiratory failure. The possible cause of uterine rupture with vacuum extraction appear to be a combination of an unengaged fetal head, an incompletely dilated cervix and an undetected mild cephalopelvic disproportion especially in grandmulti‐parae, dehiscent or weak uterine scars, prolonged traction without progress, manipulations in shoulder dystocia and obstruction and excessive non controlled traction. Uterine rupture can be minimized by careful selection of cases, proper technique and early recognition of failure.
Effect of Bilateral Oophorectomy and Peroral Estradiol Valerate Therapy on Serum Lipids
Authors: Punnonen Reijo , Rauramo Lauri 
Published: January 2017

ABSTRACTThe effect of bilateral oophorectomy upon serum lipids was studied in 25 women, whose average age was 48 years. One month after castration the triglyceride level was significantly (p<0.01) higher than before the operation. Six months later the triglyceride level had fallen slightly and the difference from the preoperative level was no longer significant. Castration did not have any significant effect on serum cholesterol and phospholipids during the seven‐month follow‐up period. The effect of peroral estradiol valerate was studied in the same way in 25 women, whose average age was 49 years. Estradiol valerate therapy (2 mg per day) was started one month after castration. After 6 months of treatment the serum phospholipids had increased slightly (p<0.05), but there was no significant effect on the cholesterol and triglyceride levels.
The Physical Work Capacity of the Expectant Mother and Its Effect on Pregnancy, Labor and the Newborn
Authors: Erkkola Risto 
Published: January 2017

ABSTRACT149 healthy primigravidae participated in the study dealing with the correlation between the physical work capacity of the mother and the course of pregnancy and labor and the possible influence of physical work capacity on the development of the fetus and placenta. 62 of the mothers were followed prospectively from the end of the first trimester and their physical work capacity was determined on two occasions prior to the 38th week of the pregnancy. All mothers were examined during the 38th week. Physical work capacity was determined using a voluntarily maximal pulse‐conducted work test on a bicycle ergometer. Prospectively the healthy mothers and the mothers which later developed toxemia or had a threatening premature labor had similar work capacities. When studied during the 38th week, the physical work capacity of the mothers treated because of threatening premature labor was significantly lower than that of the healthy or toxemic mothers. They were also very significantly more sick written and at rest during the pregnancy than other mothers. The mothers with a physical work capacity above the non‐pregnant average had an almost significantly shorter labor, when it was spontaneous. This group gave birth to more infants weighing over 3 500 g, had significantly greater placentas and fewer low values of relative placental weight than the mothers with a physical work capacity below the nonpregnant average. The physical work capacity of the mother had no influence on the duration of pregnancy, duration of induced labor, duration of the time which passed from the moment when the baby was visible until the delivery, nor on the Apgar scores recorded at one minute.
The Benefits and Risks of IUD Use
Authors: Tyrer Louise B. 
Published: January 2017

ABSTRACTNext to combination oral contraceptives (OCs), intrauterine contraceptive devices (IUDs) are the most effective form of contraception available. IUDs require only one‐time motivation, cause no systemic metabolic effects, and do not depend on continued action of the user for effectiveness. Risks, side effects, and complications of this method, including expulsion, perforation, pain, bleeding and infection, are reviewed.
Topical Uterine Anesthesia: A Preliminary Report
Authors: Hasson H. M. 
Published: January 2017

ABSTRACTThe instillation of 1 to 6 ml of 1% lidocaine was evaluated as a topical anesthetic method of reducing pain associated with uterine manipulations during gynecologic procedures. A plastic acorn cannula connected to a metal adapter and syringe was used to administer the topical anesthetic in 146 intrauterine device insertions, 16 cervical dilatations, and 18 dilatation and curettage procedures. Most patients reported satisfactory relief of pain. No complications were attributed to the topical anesthetic.
The Successful Treatment of a Case of Primary Sterility Resulting from Fredrickson's Type V Hyperlipemia and Panhypopituitarism
Authors: Biale Y. , Lewenthal H. , Ben‐Aderet N. 
Published: January 2017

ABSTRACTSuccessful treatment of primary sterility in a woman having the rare association of panhypopituitarism with Fredrickson's Type V hyperlipemia is described. Replacement therapy with l‐thyroxine, prednisone and a low fat diet cleared the patient's blood of the excessive chylomicrons and very low density lipoproteins. Ovulation was induced with human gonadotrophins, and triplets (two normal girls and a boy) were born.
Radiographic Abnormalities in Patients with Stein‐Leventhal Syndrome
Authors: Tzingounis Vassilios , Alperin Henry , Natrajan Puthugramam 
Published: January 2017

ABSTRACTRadiographic abnormalities in 254 patients with Stein‐Leventhal syndrome are presented in a retrospective study of the six‐year period from 1972–1977. Twenty‐two (8.7%) of the patients were found to have abnormal sella turcica x‐rays, eight (3.2%) patients had abnormal hysterosalpingograms and five (2.0%) patients had abnormal intravenous pyelograms. In addition, three patients with an abnormal sella turcica had serum prolactin levels greater than 45 ng/ml, which should be regarded as evidence of a pituitary adenoma. These findings suggest that serum prolactin assays and skull x‐rays with polytomography should be routinely performed on patients with Stein‐Leventhal syndrome.
Antimicrobial Activity of Amniotic Fluid Obtained Vaginally
Authors: Güner M. K. , Usmen İ , Terek Y. 
Published: January 2017

ABSTRACTTwenty‐nine amniotic fluid samples were aspirated from pregnant women at term (38–40 weeks' gestation) by tapping the bulging membrane vaginally, and their effects on Escherichia coli, Staphylococcus aureus and Candida albicans were studied. Inhibition rates were 72.41% for E coli, 68.96% for S aureus and 79.31% for C albicans. Two samples (6.90%) affected only a single organism, 18 (62.07%) affected two organisms and eight (27.59%) affected all three. Only one sample (3.45%) had no inhibitory effect on the microorganisms studied. Thus, 28 of 29 samples (96.55%) inhibited the growth of at least one of the microorganisms tested. These results are also significant because there is a high risk of contamination of amniotic fluid samples obtained through the vaginal route, although they can be obtained easier that way than through amniocentesis.
The Place of Sling Operations in Treating Genital Prolapse in Young Women
Authors: Chaudhuri S. K. 
Published: January 2017

ABSTRACTA review of 260 cases of genital prolapse in women less than 35 years of age is presented. Thirty‐six percent of the women were less than 25 years old, and 73.5% were less than 30 years. Until 1965, a total of 85 patients had undergone either Manchester operations or simple colporrhaphies after a conventional method of treatment. Since then, a different surgical approach was elected, and patients were divided into four groups according to the severity of their conditions and the types of operation required. The abdominal sling operation was performed on 110 patients, and the vaginal sling operation was performed on 18 women. Other patients had Manchester operations or simple colporrhaphies.
Autologous Transfusion in Obstetrics and Gynecology
Authors: Katz Allan R. , Walker William A. , Ross Patti Jayne , Held Berel 
Published: January 2017

ABSTRACTTwo cases are presented which illustrate the use of autologous blood transfusion for elective surgery in obstetrics and gynecology. The advantages and disadvantages are described and review of the pertinent literature over the past century is summarized.
Bilateral Tubal Pregnancy in the Presence of an IUD: A Case Report
Authors: Dajani Yahia F. , Shaer Jamal A. 
Published: January 2017

ABSTRACTBilateral tubal pregnancy was confirmed by histologic examination in a 32‐year‐old multipara with an intrauterine contraceptive device (IUD) in situ. The patient had developed intraperitoneal bleeding and hypovolemic shock. Bilateral salpingectomy was performed and was followed by a rapid recovery.
Pelvic Angiography and the Diagnosis of Carcinoma of the Uterine Cervix
Authors: Yoonessi Mahmood , Reuter Stewart R. , Meng Chien H. , Romney Seymour L. 
Published: January 2017

ABSTRACTThe hospital records and pelvic arteriograms of 31 patients with suspected, persistent or recurrent carcinoma of the uterine cervix were reviewed. The method used was found to be highly accurate in diagnosing and localizing tumors and was considered most helpful in suspected pelvic wall recurrences. Tumor encasement of the vessels can be mimicked by perivascular, postoperative and post radiation fibrosis. Tumor vessels and tumor stain are the better angiographic indicators of the presence of recurrent or persistent disease.
Endometriosis: Associations with Menorrhagia, Infertility and Oral Contraceptives
Authors: Sensky T. E. , Liu D. T. Y. 
Published: January 2017

ABSTRACTIn a retrospective study of 163 women with endometriosis, 76% had a history of menorrhagia, a larger percentage than that which might be normally expected. Only 10% of the women complained of infertility, while 13% had used oral contraceptives regularly, a much smaller proportion than expected. These findings are discussed in terms of the pathogenesis of endometriosis and the possible prophylactic role of oral contraceptives. The authors suggest the possibility that increased sensitivity to estrogens may lead to the development of endometriosis in some women.
TRH‐Induced Hyperprolactinemia and Pituitary‐Ovarian Function
Authors: Ylikorkala Olavi , Dawood M. Yusoff , Kivinen Seppo 
Published: January 2017

ABSTRACTTo elucidate the role of prolactin in the control of pituitary‐ovarian function, eight healthy women were given 80 mg of synthetic thyrotropin‐releasing hormone (TRH) orally on two consecutive days during the luteal phase of their menstrual cycle. TRH elevated serum prolactin to a mean concentration of 43.8 ng/ml on the first day and to 15.5 ng/ml on the second day. The reduced response to the second TRH dose was statistically significant (p < 0.05). Accompanying changes in concentrations of gonadotropins or ovarian steroids were not consistent. Short‐term oral administration of TRH and/or the temporary hyperprolactinemia induced by its use do not modify the pituitary‐ovarian function during the luteal phase of the menstrual cycle.
Placental Localization by Liquid Crystal Thermography
Authors: Liu D. T. Y. , Blackwell R. J. 
Published: January 2017

ABSTRACTThe accuracy of determining placentation by using plates of cholesteric thermocrystals has been studied, with the actual placental site being defined as that shown by ultrasound B scanning. In our study, 43 patients were examined, including eight with placenta previa. Although all eight cases of placenta previa were identified, there were three false‐positive test results. It is believed that suitable modification of the composition of the liquid crystal mixture will improve the accuracy of this simple technique, which would be valuable in areas where sophisticated equipment is not yet available.
Nonimmunologic Hydrops Fetalis: A Review of 19 Cases
Authors: Spahr Robert C. , Botti John J. , MacDonald Hugh M. , Holzman Ian R. 
Published: January 2017

ABSTRACTNineteen cases of nonimmunologic hydrops fetalis occurring during a nine‐year period were reviewed. The pregnancies were complicated by hydramnios (78%) and preterm delivery (84%). Hydramnios appears to be the most useful indicator of the pregnancy at risk; its occurrence should prompt ultrasonographic investigation for evidence of hydrops. Modalities available for antenatal diagnosis of underlying fetal abnormalities include amniocentesis, serologic tests, fetal cardiac monitoring, radiography, hemoglobin electrophoresis and glucose tolerance testing. A specific cause for the hydrops may not be detectable (42% of our cases were idiopathic). Management of affected pregnancies is influenced by the frequent occurrence of fetal asphyxia and premature delivery. Outcome is poor: only 32% of the babies survived beyond the neonatal period. Symptomatic treatment for the neonate includes fluid restriction, maintenance of blood sugar, support of ventilation and attention to the complications of asphyxia.
“Holostei versus Halecostomi” Problem: Insight from Cytogenetics of Ancient Nonteleost Actinopterygian Fish, Bowfin Amia calva
Authors: Majtánová Zuzana , Symonová Radka , Arias‐Rodriguez Lenin , Sallan Lauren , Ráb Petr 
Published: January 2017

ABSTRACTBowfin belongs to an ancient lineage of nonteleost ray‐finned fishes (actinopterygians) and is the only extant survivor of a once diverged group, the Halecomorphi or Amiiformes. Owing to the scarcity of extant nonteleost ray‐finned lineages, also referred as “living fossils,” their phylogenetic interrelationships have been the target of multiple hypotheses concerning their sister group relationships. Molecular and morphological data sets have produced controversial results; bowfin is considered as either the sister group to genome‐duplicated teleosts (together forming the group of Halecostomi) or to gars (Lepisosteiformes; together forming the group of Holostei). However, any detailed cytogenetic analysis of bowfin chromosomes has never been performed to address this issue. Here we examined bowfin chromosomes by conventional (Giemsa‐staining, C‐banding, base‐specific fluorescence and silver staining) and molecular (FISH with rDNA probes) cytogenetic protocols. We identified diploid chromosome number 2n = 46 with a middle‐sized submetacentric chromosome pair as the major ribosomal DNA‐bearing (45S rDNA), GC‐positive and silver‐positive element. The minor rDNA (5S rDNA) sites were localized in the pericentromeric region of one middle‐sized acrocentric chromosome pair. Comparison with available cytogenetic data of other nonteleost actinopterygians (bichirs, sturgeons, gars) and teleost species including representative of basally branching lineages showed bowfin chromosomal characteristics more similar to the teleost type than to any other nonteleosts. Particularly striking differences were identified between bowfin and gars, the latter of which were found to mimic mammalian AT/GC genomic organisation. Such conclusion however contradicts the most recent phylogenomic results and raises the question what states are ancestral and what are derived.