bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Richard met CG: reference-point and English copy-raising
Authors: PARK CHONGWON , TURNER DANIEL 
Published: October 2016

abstractThe aim of this paper is to develop a Cognitive Grammar-based analysis of English Copy-raising (CR) constructions such asRichard seems like he is dancing. We argue that the notion of reference-point plays a crucial role in licensing the matrix-subject of the construction. In CR, with the epistemic verbsseemandappear, the matrix-subject functions as a reference-point in relation to the pronominal copy (if a copy exists) in the embedded clause. The aboutness topicality of the matrix-subject in CR is expected, owing to its reference-point property. The epistemic CR construction is acceptable without a pronominal copy if the matrix-subject functions as a reference-point in relation to the complement clause. The same type of analysis is applied to the CR construction with perceptual resemblance (PR) verbs –sound,look,feel, andsmell– leading to the conclusion that the strong dichotomy between epistemic and PR verbs is illusory. It is further demonstrated that expletivethere-raising in CR is motivated by the same reference-point phenomenon. The difference betweenthere-raising and other CR examples stems from the role ofthereas a setting subject. Our reference-point-based analysis predicts a metonymic interpretation of the matrix-subject, which we attribute to the connection between reference-point and metonymy.
Strategies for Finding Prompt Radio Counterparts to Gravitational Wave Transients with the Murchison Widefield Array
Authors: Kaplan D. L. , Murphy T. , Rowlinson A. , Croft S. D. , Wayth R. B. , Trott C. M. 
Published: October 2016

AbstractWepresent and evaluate several strategies to search for prompt, low-frequency radio emission associated with gravitational wave transients using the Murchison Widefield Array. As we are able to repoint the Murchison Widefield Array on timescales of tens of seconds, we can search for the dispersed radio signal that has been predicted to originate along with or shortly after a neutron star-neutron star merger. We find that given the large, 600 deg2instantaneous field of view of the Murchison Widefield Array, we can cover a significant fraction of the predicted gravitational wave error region, although due to the complicated geometry of the latter, we only cover > 50% of the error region for approximately 5% of events, and roughly 15% of events will be located < 10° from the Murchison Widefield Array pointing centre such that they will be covered in the radio images. For optimal conditions, our limiting flux density for a 10-s long transient would be 0.1 Jy, increasing to about 1 Jy for a wider range of events. This corresponds to luminosity limits of 1038−39erg s−1based on expectations for the distances of the gravitational wave transients, which should be sufficient to detect or significantly constrain a range of models for prompt emission.
Characterisation of equine satellite cell transcriptomic profile response toβ-hydroxy-β-methylbutyrate (HMB)
Authors: Szcześniak Katarzyna A. , Ciecierska Anna , Ostaszewski Piotr , Sadkowski Tomasz 
Published: October 2016

Abstractβ-Hydroxy-β-methylbutyrate (HMB) is a popular ergogenic aid used by human athletes and as a supplement to sport horses, because of its ability to aid muscle recovery, improve performance and body composition. Recent findings suggest that HMB may stimulate satellite cells and affect expressions of genes regulating skeletal muscle cell growth. Despite the scientific data showing benefits of HMB supplementation in horses, no previous study has explained the mechanism of action of HMB in this species. The aim of this study was to reveal the molecular background of HMB action on equine skeletal muscle by investigating the transcriptomic profile changes induced by HMB in equine satellite cellsin vitro. Upon isolation from thesemitendinosusmuscle, equine satellite cells were cultured until the 2nd day of differentiation. Differentiating cells were incubated with HMB for 24 h. Total cellular RNA was isolated, amplified, labelled and hybridised to microarray slides. Microarray data validation was performed with real-time quantitative PCR. HMB induced differential expressions of 361 genes. Functional analysis revealed that the main biological processes influenced by HMB in equine satellite cells were related to muscle organ development, protein metabolism, energy homoeostasis and lipid metabolism. In conclusion, this study demonstrated for the first time that HMB has the potential to influence equine satellite cells by controlling global gene expression. Genes and biological processes targeted by HMB in equine satellite cells may support HMB utility in improving growth and regeneration of equine skeletal muscle; however, the overall role of HMB in horses remains equivocal and requires further proteomic, biochemical and pharmacokinetic studies.
Reproductive efficiency of the bethylid waspCephalonomia tarsalis:the influences of spatial structure and host density
Authors: Eliopoulos P.A. , Kapranas A. , Givropoulou E.G. , Hardy I.C.W. 
Published: October 2016

AbstractThe parasitoid waspCephalonomia tarsalis(Ashmead) (Hymenoptera: Bethylidae) is commonly present in stored product facilities. While beneficial, it does not provide a high degree of biological pest control against its host, the saw-toothed beetleOryzaephilus surinamensis(L.) (Coleoptera: Silvanidae). A candidate explanation for poor host population suppression is that adult females interfere with each other's foraging and reproductive behavior. We used simple laboratory microcosms to evaluate such mutual interference in terms of its overall effects on offspring production. We varied the density of the hosts and also the spatial structure of the environment, via the extent of population sub-division and the provision of different substrates. Production ofC. tarsalisoffspring was positively influenced by host density and by the isolation of females. With incomplete sub-division within microcosms offspring production was, in contrast, low and even zero. The provision of corrugated paper as a substrate enhanced offspring production and partially mitigated the effects of mutual interference. We recommend simple improvements to mass rearing practice and identify promising areas for further behavioral and chemical studies towards a better understanding of the mechanisms of mutual interference.
The future of Earth's oceans: consequences of subduction initiation in the Atlantic and implications for supercontinent formation
Authors: DUARTE JOÃO C. , SCHELLART WOUTER P. , ROSAS FILIPE M. 
Published: October 2016

AbstractSubduction initiation is a cornerstone in the edifice of plate tectonics. It marks the turning point of the Earth's Wilson cycles and ultimately the supercycles as well. In this paper, we explore the consequences of subduction zone invasion in the Atlantic Ocean, following recent discoveries at the SW Iberia margin. We discuss a buoyancy argument based on the premise that old oceanic lithosphere is unstable for supporting large basins, implying that it must be removed in subduction zones. As a consequence, we propose a new conceptual model in which both the Pacific and the Atlantic oceans close simultaneously, leading to the termination of the present Earth's supercycle and to the formation of a new supercontinent, which we name Aurica. Our new conceptual model also provides insights into supercontinent formation and destruction (supercycles) proposed for past geological times (e.g. Pangaea, Rodinia, Columbia, Kenorland).
One century of Nordic barley breeding: nitrogen use efficiency, agronomic traits and genetic diversity
Authors: RAJALA A. , PELTONEN-SAINIO P. , JALLI M. , JAUHIAINEN L. , HANNUKKALA A. , TENHOLA-ROININEN T. , RAMSAY L. , MANNINEN O. 
Published: October 2016

SUMMARYThe current study aimed to evaluate breeding effect on nitrogen use efficiency (NUE), its components and some agronomic traits and disease resistance in barley by using extensive germplasm covering 72 landraces and 123 cultivars released since 1910. Trials were established in southern Finland with a modified strip-plot experimental design. Prior to sowing, blocks were placement fertilized with compound nitrogen : phosphorus : potassium (NPK) fertilizer (N-P-K: 20–3–8) at the rate of 35 and 70 kg N/ha and unfertilized plots were placed at the other end of the fertilization block. The germplasm collection was genotyped with 1536 single nucleotide polymorphism (SNP) markers and phenotyped during a 2-year field experiment in 2011/12. Independent of row type, a positive breeding effect was evident in NUE and for other plant N traits, except that grain N slightly decreased. Breeding has improved NUE by 0·08 kg/year (26% over the century). Nitrogen utilization and N uptake efficiencies were also improved by breeding as were straw length, lodging tolerance, grain yield and yield components, without any sign of levelling-off. Bred cultivars were more resistant to leaf-damaging diseases, especially to net blotch. The SNP data indicated no reduction in overall genetic diversity. However, genetic diversity differed along the barley chromosomes showing either reduced or increased diversity in certain regions when landraces were compared with modern varieties.
SURVEY OF SEXUAL ACTIVITY AND CONTRACEPTIVE USE AMONG UNMARRIED YOUNG SCHOOL AND COLLEGE DROP-OUTS IN A DEFINED NIGERIAN POPULATION
Authors: Adanikin Abiodun Idowu , Adanikin Pipeloluwa Oluwayemisi , Orji Ernest Okechukwu , Adeyanju Benedict Tolulope 
Published: October 2016

SummaryThis study sought to characterize sexual behaviour, contraceptive use and contributory upbringing factors among young people who had dropped out of school or college in a Nigerian setting. A community-based, cross-sectional sexual survey of 161 young people aged between 15 and 35 who had dropped out of school or college was performed in Ado-Ekiti, south-west Nigeria, in April 2015. One hundred and nineteen of the respondents (73.9%) had had sexual intercourse. Mean age at sexual debut was 19.08±3.5 years. Of those with sexual experience, 79 (66.4%) had their sexual debut with a previous boy/girlfriend and 33 (27.7%) had it in their current relationship. Three (2.5%) respondents had first sex with a stranger. About 90% were still having sexual intercourse within 12 months of the survey; more males had had sex than females (81.1% versus 67.8%). Around 80% of those with sexual exposure practised a form of contraception, mainly use of the male condom, but fewer than 25% were all-time contraceptive users. Coming from a single-parent family (p=0.04) or from a family of poor economic status (AOR: 7.41; 95% CI: 0.69–0.83) were found to be associated with sexual debut by the age of 19 and premarital sex, respectively, in these young people. Unprotected sexual intimacy was found to be high among young school/college drop-outs in this region of Nigeria. This group of young people need targeted reproductive health intervention as they represent a potent route for HIV transmission in the region.
REPRODUCTIVE AND CHILD HEALTH SERVICES AND DEMOGRAPHIC CHANGE IN THE DISTRICTS OF UTTAR PRADESH, 2002–13
Authors: Rajbhar Mamta , Mohanty Sanjay K. 
Published: October 2016

SummaryThis study examined the effect of reproductive and child health (RCH) services on fertility and child mortality in the districts of Uttar Pradesh. It specifically measured the effect of antenatal care, medical assistance at birth, child immunization and use of modern methods of contraception on Total Fertility Rate (TFR), Infant Mortality Rate (IMR) and Under-five Morality Rate (U5MR) before and after the National Rural Health Mission (NRHM) period. Data from the 2002–04 District Level Household Survey (DLHS-2), 2012–13 Annual Health Survey (AHS) and the 2001 and 2011 Censuses of India were used. The TFR and U5MR were estimated from the Census of India with district as the unit of analysis. Descriptive statistics, composite indices, random- and fixed-effects models and difference-in-difference models were used to understand the effect of RCH services on the reduction in TFR, IMR and the U5MR. The results suggest large inter-district variations in the coverage of RCH services in the state. During the post-NRHM period, improvement was highest in safe delivery followed by immunization coverage and antenatal care and least for contraceptive use in most districts. The relative ranking of districts has not changed much over time. In 2002–04, the RCH Index was highest in Lucknow (0.442) followed by Ballia and least in Kaushambi (0.115). By 2012–13, it was highest in Jhansi (0.741) and lowest in Shrawasti (0.241). The districts of Kaushambi, Unnao, Mahoba, Banda and Hardoi performed better in the RCH Index over time, while Ballia, Gautam Buddha Nagar, Kanpur Nagar, Pratapgarh and Sonbhadra remained poor. The RCH service coverage and demographic outcomes were poor in seven districts, particularly those in eastern and western Uttar Pradesh. The regression analyses suggest that the RCH Index exerts greater influence on the reduction in IMR and U5MR, while female literacy exerts greater influence on the reduction in TFR. The results of the hybrid model suggest that a 10% change in RCH Index would lead to a 3 point decline in IMR, and a 10% increase in female literacy would lead to a 0.2 point decline in TFR. The study suggests continuing investment in female education and RCH services with a greater focus on poor-performing districts to realize demographic and health targets.
Thomson linac-based X-ray generator: a primer for theory and design
Authors: Artyukov I.A. , Bessonov E.G. , Gorbunkov M.V. , Maslova Y.Y. , Popov N.L. , Vinogradov A.V. 
Published: October 2016

AbstractThe paper presents a general theoretical framework and related Monte Carlo simulation of novel type of the X-ray sources based on relativistic Thomson scattering of powerful laser radiation. Special attention is paid to the linac X-ray generators by way of two examples: conceptual design for production of 12.4 keV photons and presently operating X-ray source of 29.4 keV photons. Our analysis shows that state-of-the-art laser and accelerator technologies enable to build up a compact linac-based Thomson source for the same X-ray imaging and diffraction experiments as in using of a large-scale X-ray radiation facility like a synchrotron or Thomson generator based on electron storage ring.
On redundancy resolution of the human thumb, index and middle fingers in cooperative object translation
Authors: Joseph Felix Orlando Maria , Behera Laxmidhar , Tamei Tomoya , Shibata Tomohiro , Dutta Ashish , Saxena Anupam 
Published: October 2016

SUMMARYRedundancy in motion, and synergy in neuromuscular coordination provides significant versatility to the human fingers while performing coordinated grasping and manipulation tasks in several ways. This paper explores how humans may resolve the redundancy in their thumb, index and middle fingers when these digits flex to cooperatively translate a small object toward the palm. It is observed that humans actively employ a secondary subtask of maximizing instantaneous manipulability that helps determine all intermediate finger configurations when performing the primary subtask of following a tip trajectory. This behavior is accurately captured by an inverse kinematic model based on aredundancyparameter. The joint angles get determined unambiguously though the redundancy parameter is shown to depend on the instantaneous finger configurations and also, to attain negative values. Further, this parameter is noted to vary significantly across subjects performing the same kinematic task. The findings, that are based on the experimental finger motion data garnered from 12 subjects, are reckoned to be of significant importance, especially in reference to the challenges in design and control of finger exoskeletons for cooperative manipulation.
A gaze control of socially interactive robots in multiple-person interaction
Authors: Yun Sang-Seok 
Published: October 2016

SUMMARYThis paper proposes a computational model for selecting a suitable interlocutor of socially interactive robots in a situation interacting with multiple persons. To support this, a hybrid approach incorporating gaze control criteria and perceptual measurements for social cues is applied to the robot. For the perception part, representative non-verbal behaviors indicating human-interaction intent are designed based on the psychological analysis of human–human interaction, and these behavioral features are quantitatively measured by core perceptual components including visual, auditory, and spatial modalities. In addition, each aspect of recognition performance is improved through temporal confidence reasoning as a post-processing step. On the other hand, two factors of the physical space and conversational intimacy are tactically applied to the model calculation as a way of strengthening social gaze control effect of the robot. Interaction experiments with performance evaluation are given to verify that the proposed model is suitable to assess intended behaviors of individuals and perform gaze behavior about multiple persons. By showing a success rate of 93.3% in human decision-making criteria, it confirms a potential to establish socially acceptable gaze control in multiple-person interaction.
TESTING MULTI-CRITERIA DECISION ANALYSIS FOR MORE TRANSPARENT RESOURCE-ALLOCATION DECISION MAKING IN COLOMBIA
Authors: Castro Jaramillo Hector Eduardo , Goetghebeur Mireille , Moreno-Mattar Ornella 
Published: October 2016

Objectives: In 2012, Colombia experienced an important institutional transformation after the establishment of the Health Technology Assessment Institute (IETS), the disbandment of the Regulatory Commission for Health and the reassignment of reimbursement decision-making powers to the Ministry of Health and Social Protection (MoHSP). These dynamic changes provided the opportunity to test Multi-Criteria Decision Analysis (MCDA) for systematic and more transparent resource-allocation decision-making.Methods: During 2012 and 2013, the MCDA framework Evidence and Value: Impact on Decision Making (EVIDEM) was tested in Colombia. This consisted of a preparatory stage in which the investigators conducted literature searches and produced HTA reports for four interventions of interest, followed by a panel session with decision makers. This method was contrasted with a current approach used in Colombia for updating the publicly financed benefits package (POS), where narrative health technology assessment (HTA) reports are presented alongside comprehensive budget impact analyses (BIAs).Results: Disease severity, size of population, and efficacy ranked at the top among fifteen preselected relevant criteria. MCDA estimates of technologies of interest ranged between 71 to 90 percent of maximum value. The ranking of technologies was sensitive to the methods used. Participants considered that a two-step approach including an MCDA template, complemented by a detailed BIA would be the best approach to assist decision-making in this context. Participants agreed that systematic priority setting should take place in Colombia.Conclusions: This work may serve as the basis to the MoHSP on its interest of setting up a systematic and more transparent process for resource-allocation decision-making.
The presence of fever in adults with influenza and other viral respiratory infections
Authors: CHUGHTAI A. A. , WANG Q. , DUNG T. C. , MACINTYRE C. R. 
Published: October 2016

SUMMARYWe compared the rates of fever in adult subjects with laboratory-confirmed influenza and other respiratory viruses and examined the factors that predict fever in adults. Symptom data on 158 healthcare workers (HCWs) with a laboratory-confirmed respiratory virus infection were collected using standardized data collection forms from three separate studies. Overall, the rate of fever in confirmed viral respiratory infections in adult HCWs was 23·4% (37/158). Rates varied by virus: human rhinovirus (25·3%, 19/75), influenza A virus (30%, 3/10), coronavirus (28·6%, 2/7), human metapneumovirus (28·6%, 2/7), respiratory syncytial virus (14·3%, 4/28) and parainfluenza virus (8·3%, 1/12). Smoking [relative risk (RR) 4·65, 95% confidence interval (CI) 1·33–16·25] and co-infection with two or more viruses (RR 4·19, 95% CI 1·21–14·52) were significant predictors of fever. Fever is less common in adults with confirmed viral respiratory infections, including influenza, than described in children. More than 75% of adults with a viral respiratory infection do not have fever, which is an important finding for clinical triage of adult patients with respiratory infections. The accepted definition of ‘influenza-like illness’ includes fever and may be insensitive for surveillance when high case-finding is required. A more sensitive case definition could be used to identify adult cases, particularly in event of an emerging viral infection.
Why is the topic of the biological embedding of experiences important for translation?
Authors: Rutter Michael 
Published: October 2016

AbstractTranslational research focuses on innovation in healthcare settings, but this is a two-way process that may have implications for either treatment or prevention. Smoking and lung cancer and the fetal alcohol syndrome are used as examples. Experimental medicine that budges basic and clinical science often constitutes a key way forward. Areas of scientific progress and challenge are discussed in relation to drug action, social cognition, cognitive neuroscience, molecular genetics, gene–environment interaction, and epigenetics. Key concepts and challenges in relation to stress include toxicity, allostatic load, the hypothalamus–pituitary–adrenal axis, and objectives versus subjective stress. The reasons for the need to test causal inferences are discussed. Various kinds of “natural experiments” are discussed in illustration using the assisted conception design, the discordant monozygotic twin design, and the study of universal exposure. Animal models are discussed in relation to enrichment and deprivation effects and the effects of infant separation experiences, epigenetic effects, and the biological embedding of experiences. Translational issues are discussed in relation to the hypothalamic–pituitary–adrenal axis, epigenetics, and inflammation. In conclusion, it is suggested that there are immediate possibilities for experimental medicine but caution is needed with respect to moving into translation too quickly.