bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis
Authors: Tedeschi Sara K. , Bathon Joan M. , Giles Jon T. , Lin Tzu‐Chieh , Yoshida Kazuki , Solomon Daniel H. 
Published: June 2017

ObjectiveTo assess whether more frequent fish consumption is associated with lower rheumatoid arthritis (RA) disease activity scores among participants in an RA cohort.MethodsWe conducted a cross‐sectional analysis using baseline data from participants in the Evaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis cohort study. Frequency of fish consumption was assessed by a baseline food frequency questionnaire assessing usual diet in the past year. Multivariable, total energy–adjusted linear regression models provided effect estimates and 95% confidence intervals (95% CIs) for frequency of fish consumption (i.e., never to <1 time/month, 1 time/month to <1 time/week, 1 time/week, and ≥2 times/week) on baseline Disease Activity Score in 28 joints (DAS28) using the C‐reactive protein (CRP) level. We also estimated the difference in DAS28‐CRP associated with increasing fish consumption by 1 serving per week.ResultsAmong 176 participants, the median DAS28‐CRP score was 3.5 (interquartile range 2.9–4.3). In an adjusted linear regression model, subjects consuming fish ≥2 times/week had a significantly lower DAS28‐CRP compared with subjects who ate fish never to <1 time/month (difference −0.49 [95% CI −0.97, −0.02]). For each additional serving of fish per week, DAS28‐CRP was significantly reduced by 0.18 (95% CI −0.35, −0.004).ConclusionOur findings suggest that higher intake of fish may be associated with lower disease activity in RA patients.
Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing
Authors: Kim Jangho , Bae Won‐Gyu , Kim Yeon Ju , Seonwoo Hoon , Choung Han‐Wool , Jang Kyoung‐Je , Park Sunho , Kim Bog Hee , Kim Hong‐Nam , Choi Kyoung Soon , Kim Myung‐Sun , Choung Pill‐Hoon , Choung Yun‐Hoon , Chung Jong Hoon 
Published: June 2017

AbstractTopographic features play a crucial role in the regulation of physiologically relevant cell and tissue functions. Here, an analysis of feature‐size‐dependent cell–nanoarchitecture interactions is reported using an array of scaffolds in the form of uniformly spaced ridge/groove structures for engineering wound healing. The ridge and groove widths of nanopatterns are varied from 300 to 800 nm and the nanotopography features are classified into three size ranges: dense (300–400 nm), intermediate (500–600 nm), and sparse (700–800 nm). On these matrices, fibroblasts demonstrate a biphasic trend of cell body and nucleus elongation showing the maximum at intermediate feature density, whereas maximum migration speed is observed at the dense case with monotonic decrease upon increasing feature size. The directional organization of cell‐synthesized fibronectin fibers can be regulated differently via the nanotopographical features. In an in vitro wound healing model, the covering rate of cell‐free regions is maximized on the dense nanotopography and decreased with increasing feature size, showing direct correlation with the trend of migration speed. It is demonstrated that the properties of repaired tissue matrices in the process of wound healing may be controlled via the feature‐size‐dependent cell–nanoarchitecture interactions, which can be an important consideration for designing tissue engineering scaffolds.
Effect of Selective CF3 Substitution on the Physical and Chemical Properties of Gold Corroles
Authors: Sudhakar Kolanu , Mizrahi Amir , Kosa Monica , Fridman Natalia , Tumanskii Boris , Saphier Magal , Gross Zeev 
Published: June 2017

AbstractGold corroles are not readily accessible and they display no interesting physical or chemical properties. A facile methodology has now been developed for obtaining selectively CF3‐substituted gold(III) corroles and the introduction of these groups has been found to have an immense effect on the structures of the complexes, their photophysical and redox properties, and on their ability to participate in catalytic processes.
Dietary TiO2 particles modulate expression of hormone‐related genes in Bombyx mori
Authors: Shi Guofang , Zhan Pengfei , Jin Weiming , Fei JianMing , Zhao Lihua 
Published: June 2017

AbstractSilkworm (Bombyx mori) is an economically beneficial insect. Its growth and development are regulated by endogenous hormones. In the present study, we found that feeding titanium dioxide nanoparticles (TiO2NP) caused a significant increase of body size. TiO2NP stimulated the transcription of several genes, including the insulin‐related hormone bombyxin, PI3K/Akt/TOR (where PI3K is phosphatidylinositol 3‐kinase and TOR is target of rapamycin), and the adenosine 5′‐monophosphateactivated protein kinase (AMPK)/target of rapamycin (TOR) pathways. Differentially expressed gene (DEG) analysis documented 26 developmental hormone signaling related genes that were differentially expressed following dietary TiO2NP treatment. qPCR analysis confirmed the upregulation of insulin/ecdysteroid signaling genes, such as bombyxin B‐1, bombyxin B‐4, bombyxin B‐7, MAPK, P70S6K, PI3k, eIF4E, E75, ecdysteroid receptor (EcR), and insulin‐related peptide binding protein precursor 2 (IBP2). We infer from the upregulated expression of bombyxins and the signaling network that they act in bombyxin‐stimulated ecdysteroidogenesis.
Knockdown of TOR causing ovarian diapause in a genetically stable brachypterous strain of Nilaparvata lugens
Authors: Liu Fangzhou , Li Kaiyin , Cai Wanlun , Zhao Jing , Zou Yulan , Hua Hongxia 
Published: June 2017

AbstractBrown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is one of the most damaging pests of rice crops. BPH is a migratory insect with a delayed ovarian development in migrants classified as reproductive diapause. The molecular mechanism of reproductive diapause remains unclear, although we suspect it might be regulated by one or more nutrient signaling pathways. The target of rapamycin (TOR) pathway regulates cell growth in response to nutritional information, which raised a hypothesis that TOR mediates BPH reproductive diapause. We used a pure brachypterous strain (BS) and a predominantly macropterous strain (MS) to investigate the roles of NlTOR in BPH reproductive diapause. We found that NlTOR is expressed from the nymphal to adult stages, with a higher expression level of NlTOR in BS adults at 1, 2, and 4 days posteclosion than in MS at the same time points. Injection of dsNlTOR into BS nymphs resulted in the termination of BPH female ovary development and the retardation of nymph development. We infer that TOR signaling functions in BPH reproductive diapause by regulating the expression of NlFoxA and NlVitellogenin.
Prevalence of Orofacial Clefts among Live Births in China: A Systematic Review and Meta‐Analysis
Authors: Wang Mengying , Yuan Yuan , Wang Zifan , Liu Dongjing , Wang Zhuqing , Sun Feng , Wang Ping , Zhu Hongping , Li Jing , Wu Tao , Beaty Terri H. 
Published: June 2017

BackgroundOrofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta‐analysis to estimate the prevalence of OFCs.MethodsThe systematic review and meta‐analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta‐analysis, including subgroup analysis, was conducted to estimate the pooled prevalence.ResultsA total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random‐effects model of meta‐analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1–1.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1–4.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (p‐value = 0.47).ConclusionThe overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011–1019, 2017. © 2017 Wiley Periodicals, Inc.
Contribution to the reduction‐induced fluorescence enhancement of natural organic matter: Aromatic ketones outweigh quinones
Authors: Xie Pengfei , Zhou Lei , Zhang Zhiguo , Ma Jiahai 
Published: June 2017

AbstractThis work involves the comparison of the fluorescence excitation − emission matrices of different low‐molecular‐weight carbonyl compounds and natural organic matter (NOM). The aim is to determine if quinone or aromatic ketone groups are more responsible for the reduction‐induced fluorescence enhancement of NOM. After reduction, the aromatic ketones showed a significantly greater fluorescence change than the quinones, proving that the former play a more important role. Further analysis of the fluorescence of the NOM samples after re‐oxidization by oxygen with a Cu2+ catalyst, provided additional reliable evidence in support of the dominant role of aromatic ketones in the fluorescence change. This work demonstrates that aromatic ketone moieties should be given more attention when considering the physicochemical properties of NOM and related environmental processes.
Synthesis of Flower‐like Cu3[MoO4]2O from Cu3(MoO4)2(OH)2 and Its Application for Lithium‐Ion Batteries: Structure‐Electrochemical Property Relationships
Authors: Swain Basudev , Lee Duk‐Hee , Kim Jun‐Sik , Lee Chan‐Gi , Kim Dong‐Wan , Park Kyung‐Soo 
Published: June 2017

AbstractFlower‐like Cu3[MoO4]2O microspheres have been synthesized by using a sequential process from lindgrenite (Cu3(MoO4)2(OH)2). Lindgrenite nanoflowers were synthesized through a simpler route by using an aqueous chemical precipitation technique at room temperature without any surfactants or template. Subsequently, 3D flower‐like Cu3[MoO4]2O microspheres have been synthesized by annealing at 300 °C for 2 h from lindgrenite (Cu3(MoO4)2(OH)2). From the XRD pattern, FTIR spectrum, SEM and TEM analysis, flower‐like Cu3[MoO4]2O (ca. 5 μm) microspheres have been obtained, which were assembled from 3–4 nm thick nanosheets with an orthorhombic structure. Application of 3D flower‐like microspheres as an anode material for lithium‐ion batteries (LIBs) has been investigated and the possible electrochemical mechanism is analyzed. Electrochemical characterization of the Cu3[MoO4]2O nanoflowers as an anode material for LIBs has exhibited good cycle stability and a high coulombic efficiency during operation. The electrochemical activity was attributed to the unique structure of the Cu3[MoO4]2O microspheres, which provide more active sites for Li‐ion storage as well as a reduced transfer resistance. This work has explored a simple synthesis strategy for the synthesis of flower‐like Cu3[MoO4]2O microspheres without templates, additives, or surfactants, which exhibit a basis for not only high electrochemical performance in reversible Li storage, but also cycle stability.
Green Synthesis of A2SiF6 (A=Li–Cs) Nanoparticles using Ionic Liquids as Solvents and as Fluorine Sources: A Simple Approach without HF
Authors: Olchowka Jacob , Suta Markus , Wickleder Claudia 
Published: June 2017

AbstractIn this Communication, nanoparticles of the fluoridosilicates A2SiF6 (A=Li, Na, K, Rb, Cs), which are extremely promising host lattices for future LEDs, are presented for the first time. The preparation method we introduce here is a very simple and energy and time saving one, moreover the usage of toxic HF or elemental fluorine is avoided. In detail, the ionic liquid [Bmim]PF6 was used both as solvent and fluoride source in an ionothermally assisted microwave synthesis. The small size of the so‐obtained nanoparticles is of huge relevance for their applications as thin films or for the coverage of surfaces, for example in next‐generation white LEDs upon doping with Mn4+.
Exciton coupling between enones: Quassinoids revisited
Authors: Pescitelli Gennaro , Di Bari Lorenzo 
Published: June 2017

AbstractThe electronic circular dichroism (ECD) spectra of two previously reported quassinoids containing a pair of enone chromophores are revisited to gain insight into the consistency and applicability of the exciton chirality method. Our study is based on time‐dependent Density Functional Theory calculations, transition and orbital analysis, and numerical exciton coupling calculations. In quassin (1) the enone/enone exciton coupling is quasi‐degenerate, yielding strong rotational strengths that account for the observed ECD spectrum in the enone π‐π* region. In perforalactone C (2) the nondegenerate coupling produces weak rotational strengths, and the ECD spectrum is dominated by other mechanisms of optical activity. We remark the necessity of a careful application of the nondegenerate exciton coupling method in similar cases.
Repeated procedures at the generator pocket are a determinant of implantable cardioverter‐defibrillator infection
Authors: Arana‐Rueda Eduardo , Pedrote Alonso , Frutos‐López Manuel , Acosta Juan , Jauregui Beatriz , García‐Riesco Lorena , Arce‐León Álvaro , Gómez‐Pulido Federico , Sánchez‐Brotons Juan A. , Gutiérrez‐Carretero Encarnación , de Alarcón‐González Arístides 
Published: June 2017

BackgroundRates of cardiac‐device infections have increased in recent years, but the current incidence and risk factors for infection in patients with implantable cardioverter‐defibrillators (ICDs) are not well known.HypothesisThe increasing number of ICD infections is related to accumulated pocket manipulations over time.MethodsThis single‐center, prospective study included patients that underwent ICD implantation from 2008 to 2015. The endpoint was time to infection. Multivariate analysis was performed to identify independent risk factors related to infection.ResultsThe study included a total of 570 patients, of whom 419 (73.5%) underwent a first implantation. Mean age was 59 ± 14 years, and 80% were male. During a median follow‐up of 36 months (interquartile range, 18–61 months; 1887 patient‐years), infection was identified in 26 patients (4.56%), an incidence of 14.9 × 1000 patient‐years. Median time to infection was 9.7 months (interquartile range, 1.35–23.4 months), and 38.5% were late infections (beyond 12 months of follow‐up). In patients with replacement implants, the incidence was 3‐fold higher than in first implantations (27.7 vs 9.1 × 1000 patient‐years; P = 0.002). Cox regression identified 2 independent predictors of ICD infection: cumulative number of interventions at the generator pocket (hazard ratio: 1.92, 95% confidence interval: 1.42‐2.6, P < 0.001) and pocket hematoma (hazard ratio: 7.0, 95% confidence interval: 2.7‐17.9, P < 0.0001).ConclusionsThe incidence of infection in ICD patients is greater than previously reported, largely due to late infections. Each new cumulative intervention at the same generator pocket nearly doubles the risk of infection.
Fluctuations of TASEP on a Ring in Relaxation Time Scale
Authors: Baik Jinho , Liu Zhipeng 
Published: June 2017

AbstractWe consider the totally asymmetric simple exclusion process on a ring with flat and step initial conditions. We assume that the size of the ring and the number of particles tend to infinity proportionally and evaluate the fluctuations of tagged particles and currents. The crossover from the KPZ dynamics to the equilibrium dynamics occurs when the time is proportional to the 3/2 power of the ring size. We compute the limiting distributions in this relaxation time scale. The analysis is based on an explicit formula of the finite‐time one‐point distribution obtained from the coordinate Bethe ansatz method. © 2017 Wiley Periodicals, Inc.
Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs)
Authors: Dunbar Andrew , Nazir Abbas , Levine Ross 
Published: June 2017

AbstractMyeloproliferative neoplasms (MPNs) are a class of hematologic diseases characterized by aberrant proliferation of one or more myeloid lineages and progressive bone marrow fibrosis. In 2005, seminal work by multiple groups identified the JAK2V617F mutation in a significant fraction of MPN patients. Since that time, murine models of JAK2V617F have greatly enhanced the understanding of the role of aberrant JAK‐STAT signaling in MPN pathogenesis and have provided an in vivo pre‐clinical platform that can be used to develop novel therapies. From early retroviral transduction models to transgenics, and ultimately conditional knock‐ins, murine models have established that JAK2V617F alone can induce an MPN‐like syndrome in vivo. However, additional mutations co‐occur with JAK2V617F in MPNs, often in proteins involved in epigenetic regulation that can dramatically influence disease outcomes. In vivo modeling of these mutations in the context of JAK2V617F has provided additional insights into the role of epigenetic dysregulation in augmenting MPN hematopoiesis. In this overview, early murine model development of JAK2V617F is described, with an analysis of its effects on the hematopoietic stem/progenitor cell niche and interactions with downstream signaling elements. This is followed by a description of more recent in vivo models developed for evaluating the effect of concomitant mutations in epigenetic modifiers on MPN maintenance and progression. Mouse models of other driver mutations in MPNs, including primarily calreticulin (CALR) and Tpo‐receptor (MPL), which occur in a significant percentage of MPN patients with wild‐type JAK2, are also briefly reviewed. © 2017 by John Wiley & Sons, Inc.
Species-specific metabolism of naphthalene and phenanthrene in 3 species of marine teleosts exposed to Deepwater Horizon crude oil
Authors: Pulster Erin L. , Main Kevan , Wetzel Dana , Murawski Steve 
Published: June 2017

Abstract

The 2 most abundant polycyclic aromatic hydrocarbons (PAHs) measured in Deepwater Horizon crude oil, naphthalene and phenanthrene, and their associated homologs have both been shown to be acutely toxic in fish. Although fish have a relatively high metabolic capacity for PAHs, hydroxylated PAH (OH-PAH) derivatives formed during the initial metabolic response can negatively impact the health of fish. Species-specific metabolism of naphthalene and phenanthrene was evaluated in 3 marine teleosts, red drum (Scianops ocellatus), Florida pompano (Trachinotus carolinus), and southern flounder (Paralichthys lethostigma). Fish were exposed to Deepwater Horizon crude oil by intraperitoneal injections at time 0 and 48 h, with bile sampling events at 24 and 72 h post injection. The data suggested metabolic induction in Florida pompano and red drum, whereas southern flounder may have demonstrated metabolic fatigue. By 24 h post injection, overall profiles of red drum and southern flounder were dominated by hydroxylated phenanthrene metabolites; conversely, the Florida pompano profiles were dominated by monohydroxylated naphthalenes. In addition, Florida pompano had faster overall relative biotransformation rates, suggesting their potential decreased susceptibility to adverse effects. Red drum and southern flounder had much lower relative biotransformation rates, indicating their probable susceptibility to adverse outcomes after naphthalene and phenanthrene exposures. To our knowledge, the present study is the first to investigate monohydroxylated PAHs in fish exposed to Deepwater Horizon oil. Environ Toxicol Chem 2017;36:3168–3176. © 2017 © 2017 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
Recovery from reproductive and morphological abnormalities in medaka (Oryzias latipes) following a 14-day exposure to diclofenac
Authors: Yokota Hirofumi , Higashi Kaho , Hanada Erina , Matsuzaki Ei , Tsuruda Yukinari , Suzuki Tomoko , Nakano Eiko , Eguchi Sayaka 
Published: June 2017

Abstract

Mating pairs of medaka (Oryzias latipes) were exposed to diclofenac at measured concentrations of 0 (control), 7.1, 37, and 78 μg/L for 14 d under static-renewal conditions. Effects on reproductive success, as well as morphological abnormalities, of the fish were assessed. During the exposure period, both fecundity and fertility were significantly decreased in the 37- and 78-μg/L treatment groups, and swollen abdomens in females were observed in all exposure groups. Notably, a defect of the lower jaw was also observed in 4 male fish: 2 at 37 μg/L and 2 at 78 μg/L of diclofenac. Subsequently, we investigated whether the reproductive and morphological abnormalities induced by diclofenac would be permanent or reversible once the medaka were returned to clean water. The reproductive ability of paired medaka was gradually restored to fish that were cultured in clean water for 14 d. After this period in clean water, we also observed a noticeable decrease in swollen abdomens in females; however, mandibular defects in the males remained, even after the 14-d recovery period. Radiographic and histochemical examinations revealed that diclofenac might affect bone remodeling in the lower jaw of male medaka because of a disruption in osteoclast function. These results suggest that reproductive impairments in pairs of medaka exposed to diclofenac may be reversible but that skeletal deformities (i.e., mandibular defect) in males may be persistent. Environ Toxicol Chem 2017;36:3277–3283. © 2017 SETAC
Mechanical damage to green and red lentil seeds
Authors: Shahbazi Feizollah , Valizade Saman , Dowlatshah Ali 
Published: June 2017

AbstractIn this research, the breakage susceptibility of two classes of lentil (green and red) was evaluated as affected by impact energy and seed moisture content. The experiments were conducted at impact energies of 0.1, 0.2 and 0.3 J, and moisture contents of 10, 12.5, 15, 17.5, 20 and 25% (wet basis). Results showed that red lentil seeds had more breakage than green seeds and the difference in breakage percentage between green and red lentil seeds was significant at 0.01% level according to analysis of variance (p < .01). Percentage breakage of both green and red lentil seeds increased as the energy of impact increased. With increasing the seed moisture content of the both green and red lentils, the breakage percentage of seeds decreased. The average values of seeds breakage green and red lentil seeds varied from 100 to 67.7% and from 100 to 93.1%, respectively, as the seeds moisture content increased from 10 to 25%. The optimum seed moisture at which minimum damage was observed was 17.5% for green lentil and 15% for red lentil. Mathematical relationships composed of lentil seeds moisture content and energy of impact were developed for accurate description of the breakage percentage of green and red lentil seeds under impact loading.