bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Transcranial Magnetic Stimulation on the Cognitive Control of Emotion
Authors: Lantrip Crystal , Gunning Faith M. , Flashman Laura , Roth Robert M. , Holtzheimer Paul E. 
Published: January 2017

Abstract
Depression negatively impacts quality of life and is associated with high mortality rates. Recent research has demonstrated that improvement in depression symptoms with transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) may involve changes in the cognitive control network, a regulatory system modulating the function of cognitive and emotional systems, composed of the DLPFC, dorsal anterior cingulate, and posterior parietal cortices. Transcranial magnetic stimulation to the DLPFC node of the cognitive control network may have antidepressant efficacy via direct effects on cognitive control processes involved in emotion regulation. This review provides a review of the impact of TMS on cognitive control processes, especially those related to emotion regulation, and posits that these effects are critical to the mechanism of action of TMS for depression. Treatment implications and future directions for study are discussed.
Serum Oxytocin Concentration in Patients Receiving Electroconvulsive Therapy
Authors: Barhale Chinmay , Raju M.S.V.K. , Pawar Alka V. , Kadam Krishna , De Sousa Avinash , Andrade Chittaranjan 
Published: January 2017

Background
Neuroendocrine biomarkers have long been studied in the context of electroconvulsive therapy (ECT). We prospectively assessed serum oxytocin change and moderators thereof in an exploratory study of patients receiving ECT.

Methods
Serum oxytocin concentrations were assessed immediately before and 1 to 3 minutes after the first ECT in 33 patients with schizophrenia (n = 14), other nonaffective psychosis (n = 6), mania (n = 10), and depression (n = 3) who received 6 to 7 bitemporal, brief-pulse ECTs. Change in serum oxytocin was assessed in the sample as a whole, and as a function of age, sex, diagnosis, and treatment response. The primary outcome was change in serum oxytocin in the overall sample.

Results
There was much variation across patients; oxytocin concentrations increased marginally by a mean (standard deviation) (M [SD]) of 6.4 (82.7) pg/mL (P = 0.43). The M (SD) change was −8.2 (85.0) pg/mL in patients with schizophrenia and other nonaffective psychoses (P = 0.84). There was no significant correlation between change in Brief Psychiatric Rating Scale scores and change in oxytocin concentrations in patients with schizophrenia, other nonaffective psychoses, and mania (ρ = 0.10, P = 0.61). Serum oxytocin rose in men, after ECT, and fell in women (P = 0.01).

Conclusions
Change in serum oxytocin immediately after the first ECT in a course may not be a useful biomarker of ECT action. This is the first report on the subject in a sample comprising mostly patients with nonaffective psychosis and mania rather than depression. We discuss our findings in the light of previous research and offer general conclusions about the field.
Snaptron: querying and visualizing splicing across tens of thousands of RNA-seq samples
Authors: Wilks Christopher , Gaddipati Phani , Nellore Abhinav , Langmead Ben 
Published: January 2017

AbstractAs more and larger genomics studies appear, there is a growing need for comprehensive and queryable cross-study summaries. Snaptron is a search engine for summarized RNA sequencing data with a query planner that leverages R-tree, B-tree and inverted indexing strategies to rapidly execute queries over 146 million exon-exon splice junctions from over 70,000 human RNA-seq samples. Queries can be tailored by constraining which junctions and samples to consider. Snaptron can also rank and score junctions according to tissue specificity or other criteria. Further, Snaptron can rank and score samples according to the relative frequency of different splicing patterns. We outline biological questions that can be explored with Snaptron queries, including a study of novel exons in annotated genes, of exonization of repetitive element loci, and of a recently discovered alternative transcription start site for the ALK gene. Web app and documentation are athttp://snaptron.cs.jhu.edu. Source code is athttps://github.com/ChristopherWilks/snaptronunder the MIT license.
Utilization of network graph connectivity to evaluate complications of inpatient medical and surgical populations as a method to prioritize quality improvement efforts
Authors: Bear-Pfaffendorf Kattie 
Published: January 2017

AbstractNetwork graphs can provide a quantitative framework for identifying complications with significant volumes and strong relationships to other complications, as a method for prioritization of quality improvement work. Here we examine the application of network graphing techniques to acute care inpatient complications on acute care medical-surgical units of a quaternary care center. The 3M PPC software identified 66 complications among 106 unique patients with two or more complications during an inpatient hospital stay. The network graph highlighted renal failure without dialysis and septicemia and severe infections as highly connected complications in this population.
JDINAC: joint density-based non-parametric differential interaction network analysis and classification using high-dimensional sparse omics data
Authors: Ji Jiadong , He Di , Feng Yang , He Yong , Xue Fuzhong , Xie Lei 
Published: January 2017

AbstractMotivationA complex disease is usually driven by a number of genes interwoven into networks, rather than a single gene product. Network comparison or differential network analysis has become an important means of revealing the underlying mechanism of pathogenesis and identifying clinical biomarkers for disease classification. Most studies, however, are limited to network correlations that mainly capture the linear relationship among genes, or rely on the assumption of a parametric probability distribution of gene measurements. They are restrictive in real application.ResultsWe propose a new Joint density based non-parametric Differential Interaction Network Analysis and Classification (JDINAC) method to identify differential interaction patterns of network activation between two groups. At the same time, JDINAC uses the network biomarkers to build a classification model. The novelty of JDINAC lies in its potential to capture non-linear relations between molecular interactions using high-dimensional sparse data as well as to adjust confounding factors, without the need of the assumption of a parametric probability distribution of gene measurements. Simulation studies demonstrate that JDINAC provides more accurate differential network estimation and lower classification error than that achieved by other state-of-the-art methods. We apply JDINAC to a Breast Invasive Carcinoma dataset, which includes 114 patients who have both tumor and matched normal samples. The hub genes and differential interaction patterns identified were consistent with existing experimental studies. Furthermore, JDINAC discriminated the tumor and normal sample with high accuracy by virtue of the identified biomarkers. JDINAC provides a general framework for feature selection and classification using high-dimensional sparse omics data.Availability:R scripts available athttps://github.com/jijiadong/JDINACContact:lxie@iscb.orgSupplementary information:Supplementary data are available at bioRxiv online.
Interaction of Whey Proteins with Phenolic Derivatives Under Neutral and Acidic pH Conditions
Authors: Cao Yanyun , Xiong Youling L. 
Published: January 2017

AbstractIntegration of gallic acid (GA) and its derivative epigallocatechin gallate (EGCG; 20, 120, and 240 μmol/g, protein basis) into whey protein isolate (WPI) at room temperature and pH 3.0 and pH 7.0 was investigated. At pH 7.0, both phenolics caused significant structural changes and EGCG induced greater digestibility of WPI. Total sulfhydryl in WPI decreased from 28.6 to 7.6 μmol/g and surface hydrophobicity declined by nearly 50% with 240 μmol/g EGCG at pH 7.0. Similar but less appreciable changes were produced by GA and at pH 3.0. Isothermal titration and fluorescence quenching tests showed moderately weak binding of WPI with GA but strong binding with EGCG at pH 7.0. Both phenolics at high concentrations lowered the thermal transition temperature of β‐lactoglobulin by 0.5 °C to 1.4 °C and promoted its digestion. The phenolics also displayed a remarkable synergism with peptides in the WPI digest exerting radical scavenging activity.
Thermal Stability Improvement of Rice Bran Albumin Protein Incorporated with Epigallocatechin Gallate
Authors: Zhou Zhongkai , Xu Jingjing , Liu Yuqian , Meng Demei , Sun Xiaoli , Yi Hong , Gao Yunjing , Sun Guoyu , Strappe Padraig , Blanchard Chris , Yang Rui 
Published: January 2017

AbstractRice bran albumin protein (RAP) is sensitive to thermal changes and tends to degrade when exposed to high‐temperature processing. In this work, RAP–epigallocatechin‐3‐gallate (EGCG) complex (RAPE) was prepared and the thermal stability was evaluated. Fluorescence results showed that EGCG could interact with RAP with a binding number n of 0.0885:1 (EGCG:RAP, w/w) and a binding constant K of 1.02 (± 0.002) ×104/M, suggesting both hydrogen bonding and van der Waals forces played an important role. FTIR analysis demonstrated that EGCG could induce secondary structural changes in RAP above a ratio of 1.6:1 (EGCG:RAP, w/w). Interestingly, the secondary structure changes of RAPE at different temperatures (25, 50, 60, 70, and 80 °C) were inhibited compared with that for RAP, suggesting RAPE was more resistant and stable to the heat treatment. In addition, a dense porous structure of RAPE was achieved due to the EGCG binding after thermal treatment. Furthermore, the Tpeak temperature of RAPE increased significantly from 64.58 to 74.16 °C and the enthalpy also increased from 85.53 to 138.52 J/g with a mass ratio increasing from 0 to 3.2 (EGCG:RAP, w/w), demonstrating the thermal stability of RAPE. In addition, the valine, methionine, and lysine content in RAPE were significantly higher than RAP following 80 °C treatment for 20 min (P < 0.05), exhibiting enhanced amino acid profiles, which might be due to EGCG–RAP interactions and microenvironment changes around relevant amino acids. These findings demonstrate that EGCG has the potential to improve the thermal stability of sensitive proteins and is beneficial for usage in the food industry.
Differential Scanning Calorimetry Analysis of the Effects of Heat and Pressure on Protein Denaturation in Soy Flour Mixed with Various Types of Plasticizers
Authors: Kweon Meera , Slade Louise , Levine Harry 
Published: January 2017

AbstractThe effects of heat and pressure on protein denaturation in soy flour were explored by an experimental design that used pressure (atmospheric to 600 MPa), temperature (room to 90 °C), time (1 to 60 min), and type of aqueous plasticizer (NaCl, sucrose, betaine, and lactobionic acid (LBA)) as factors. When 50% (w/w) soy flour‐water paste was high hydrostatic pressure (HHP)‐treated for 20 min at 25 °C, the treatment at 200 MPa showed a small effect on denaturation of only the 7S soy globulin, but the treatment at 600 MPa showed a significant effect on denaturation of both the 7S and 11S soy globulins. The treatment at 60 °C showed a less‐pronounced effect on denaturation of the 11S globulin, even at 600 MPa, but that at 90 °C showed a similar extent of denaturation of the 11S globulin at 600 MPa to that at 25 °C. Chaotropic 2N NaCl, 50% sucrose‐, 50% betaine‐, or 50% LBA‐water solutions showed protective effects on protein denaturation during HHP treatment at 25 °C. Although LBA enhanced the extent of thermostability of soy protein less than did 2N NaCl, LBA exhibited better stabilization against pressure. The results from DSC analysis demonstrated that thermostable soy proteins were not always barostable.
Effects of Catechol O‐Methyl Transferase Inhibition on Anti‐Inflammatory Activity of Luteolin Metabolites
Authors: Ha Sang Keun , Lee Jin‐Ah , Cho Eun Jung , Choi Inwook 
Published: January 2017

AbstractAlthough luteolin is known to have potent anti‐inflammatory activities, much less information has been provided on such activities of its hepatic metabolites. Luteolin was subjected to hepatic metabolism in HepG2 cells either without or with catechol O‐methyl transferase (COMT) inhibitor. To identify hepatic metabolites of luteolin without (luteolin metabolites, LMs) or with COMT inhibitor (LMs+CI), metabolites were treated by β‐glucuronidase and sulfatase, and found that they were composed of glucuronide and sulfate conjugates of diosmetin in LMs or these conjugates of luteolin in LMs+CI. LMs and LMs+CI were examined for their anti‐inflammatory activities on LPS stimulated Raw 264.7 cells. Expression of iNOS and production of nitric oxide and pro‐inflammatory cytokines such as TNF‐α, IL‐1β, and IL‐6 were suppressed more effectively by the treatment with LMs+CI than LMs.Our data provide a new insight on possible improvement in functional properties of luteolin on target cells by modifying their metabolic pathway in hepatocytes.
Influence of Fermentation Process on the Anthocyanin Composition of Wine and Vinegar Elaborated from Strawberry
Authors: Hornedo‐Ortega Ruth , Álvarez‐Fernández M. Antonia , Cerezo Ana B. , Garcia‐Garcia Isidoro , Troncoso Ana M. , Garcia‐Parrilla M. Carmen 
Published: January 2017

AbstractAnthocyanins are the major polyphenolic compounds in strawberry fruit responsible for its color. Due to their sensitivity, they are affected by food processing techniques such as fermentation that alters both their chemical composition and organoleptic properties. This work aims to evaluate the impact of different fermentation processes on individual anthocyanins compounds in strawberry wine and vinegar by UHPLC‐MS/MS Q Exactive analysis. Nineteen, 18, and 14 anthocyanin compounds were identified in the strawberry initial substrate, strawberry wine, and strawberry vinegar, respectively. Four and 8 anthocyanin compounds were tentatively identified with high accuracy for the 1st time to be present in the beverages obtained by alcoholic fermentation and acetic fermentation of strawberry, respectively. Both, the total and the individual anthocyanin concentrations were decreased by both fermentation processes, affecting the alcoholic fermentation to a lesser extent (19%) than the acetic fermentation (91%). Indeed, several changes in color parameters have been assessed. The color of the wine and the vinegar made from strawberry changed during the fermentation process, varying from red to orange color, this fact is directly correlated with the decrease of anthocyanins compounds.
Comparing Costs of Onsite Best Management Practices to Nutrient Credits for Stormwater Management: A Case Study in Virginia
Authors: Nobles Alicia L. , Goodall Jonathan L. , Fitch G. Michael 
Published: January 2017

AbstractBest management practices (BMPs) are widely used to mitigate impacts of increased impervious surfaces on stormwater runoff. However, there is limited detailed and up‐to‐date information available on the cost of designing, constructing, and maintaining BMPs over their lifetime. The objective of this study is to analyze BMPs recently constructed by the Virginia Department of Transportation (VDOT) to quantify their total cost per pound of phosphorus removed annually. A motivating factor for the study is recent changes to regulatory guidelines in Virginia which allow for full or partial substitution of purchased nutrient credits in lieu of constructing onsite BMPs to achieve compliance with stormwater quality regulations. Results of the analysis of nine BMPs found their cost ranged from $20,100 to $74,900, in 2014 dollars, per pound ($44,313‐$165,126 per kg) of phosphorus removed. Based on these results and assuming current credit prices procured by VDOT, purchasing nutrient credits is a cost‐effective option for the agency, especially when factoring in the cost of additional right of way for the BMP. Based on this finding, we expect compliance with stormwater quality regulations through credit purchases to become more widely used in Virginia. Moving forward, we suggest more direct tracking of BMP costs to support comparisons between BMP costs across a range of types and conditions to credit purchases for meeting stormwater regulations.
Flow‐Biology Relationships Based on Fish Habitat Guilds in North Carolina
Authors: Patterson Lauren , Phelan Jennifer , Goudreau Chris , Dykes Robert 
Published: January 2017

AbstractThe health of freshwater biota is dependent on streamflow, yet identification of the flow regimes required to maintain ecological integrity remains challenging to states in the United States seeking to establish ecological flows. We tested the relationship between decreases in streamflow and Shannon‐Weaver diversity index of fish species for four flow‐based habitat guilds: riffle, riffle‐run, pool‐run, and pool in North Carolina. We found species that prefer shallow habitats, such as riffles and riffle‐runs were the most sensitive to decreases in streamflow; whereas no significant relationships were found for pool or pool‐run species. The sensitivity to decreases in streamflow was greatest during summer and fall, when streams are naturally lower. When all fish habitat guilds were included in the assessment of flow‐biology relationships, there were no significant relationships to decreases in streamflow. As the sensitivity of fish to reductions in streamflow is not constant across habitat guilds, combining all fish species together for flow‐biology analyses may greatly underestimate the response of fish species to decreases in flow and should be acknowledged when establishing ecological flows.
Transjugular intrahepatic portosystemic shunt: Indications, complications, survival and its use as a bridging therapy to liver transplant in Western Australia
Authors: Pateria Puraskar , Jeffrey Gary P , Garas George , Tibballs Jonathan , Ferguson John , Delriviere Luc , Huang Yi , Adams Leon A , MacQuillan Gerry 
Published: January 2017

AbstractIntroductionInsertion of transjugular intrahepatic portosystemic shunt (TIPS) is an established therapeutic option to treat the complications of portal hypertension. The purpose of this study is to review the experience of a single Australian institute with TIPS and evaluation of result to emphasize the indication, aetiology of portal hypertension, prognostic factors, complications and survival. Use of TIPS as a bridge to liver transplantation was also analysed.MethodA retrospective cohort study of patients treated with TIPS at The Western Australian Liver Transplant Unit, Sir Charles Gairdner Hospital, over a period of 12 years. Kaplan–Meier method was used for survival analysis and cox‐regression analysis was used to analyse the predictors of survival.ResultsFifty‐three patients underwent TIPS between January 2000 and March 2012. The cumulative survival at 1 month, 1 year and 5 years was 90%, 70.9% and 43.9%, respectively. The predictors of survival were indication (variceal bleeding versus ascites, hazard ratio 3.19, CI 95%: 1.164–8.794, P = 0.024) and Model of End Stage Liver Disease score (Hazard ratio 2.513, CI 95%: 1.087–5.810, P = 0.031). Patients who underwent TIPS as a bridge to liver transplant had a 5‐year survival of 71% that is comparable to the overall survival of Western Australian liver transplant unit.ConclusionTransjugular intrahepatic portosystemic shunt is a safe and effective method of treatment of complications of portal hypertension. TIPS can be safely used as a bridging therapy to liver transplant. Despite small number of TIPS being performed at our institute, our technical results are comparable to the institutes with bigger number of patients.
Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK‐rhinitis study
Authors: Bousquet J. , Caimmi D. P. , Bedbrook A. , Bewick M. , Hellings P. W. , Devillier P. , Arnavielhe S. , Bachert C. , Bergmann K. C. , Canonica G. W. , Chavannes N.H. , Cruz A. A. , Dahl R. , Demoly P. , De Vries G. , Mathieu‐Dupas E. , Finkwagner A. , Fonseca J. , Guldemond N. , Haahtela T. , Hellqvist‐Dahl B. , Just J. , Keil T. , Klimek L. , Kowalski M. L. , Kuitunen M. , Kuna P. , Kvedariene V. , Laune D. , Pereira A. M. , Carreiro‐Martins P. , Melén E. , Morais‐Almeida M. , Mullol J. , Muraro A. , Murray R. , Nogueira‐Silva L. , Papadopoulos N. G. , Passalacqua G. , Portejoie F. , Price D. , Ryan D. , Samolinski B. , Sheikh A. , Siroux V. , Spranger O. , Todo Bom A. , Tomazic P. V. , Valero A. , Valovirta E. , Valiulis A. , VandenPlas O. , van der Meulen S. , van Eerd M. , Wickman M. , Zuberbier T. 
Published: January 2017

AbstractBackgroundThe use of Apps running on smartphones and tablets profoundly affects medicine. The MASK‐rhinitis (MACVIA‐ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients’ lives. It is freely available in 20 countries (iOS and Android platforms).AimsTo assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions.MethodsThe Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1–2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms.ResultsBy 1 June 2016, 3260 users had registered with the Allergy Diary and 2710 had completed the baseline questionnaire. Troublesome symptoms were found mainly in the users with the most symptoms. Around 50% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment. Sleep was impaired by troublesome symptoms and nasal obstruction.ConclusionsThis is the first App (iOS and Android) to have tested for allergic rhinitis and conjunctivitis. A simple questionnaire administered by cell phones enables the identification of phenotypic differences between a priori defined rhinitis groups. The results suggest novel concepts and research questions in allergic rhinitis that may not be identified using classical methods.
Novel roles of oligodendrocyte precursor cells in the developing and damaged brain
Authors: Maki Takakuni 
Published: January 2017

AbstractRecent research advances have been gradually revealing that oligodendrocyte precursor cells (OPC) have more diverse and crucial roles in the brain than previously recognized, actively participating in the control of brain homeostasis. OPC are uniformly distributed in both gray and white matter, showing robust proliferative and migratory potential with constant surveillance capacity in the adult brain. In addition to the well‐known role of a reservoir for mature oligodendrocytes, which form myelin sheaths and promote saltatory nerve conduction, OPC have been shown to regulate neuronal, glial and vascular systems in a direct and reciprocal fashion. Although the exact functions of “reactive” OPC after central nervous system injury remain poorly defined, they could have dual opposing “detrimental” and “beneficial” effects, responding to various types of injury in different locations. The developmental processes that regulate oligodendrogenesis are partly reproduced after the damage of oligodendrocytes, providing some insights for understanding the regenerative responses of OPC after injury. However, OPC might also acquire new properties under pathological conditions. In the present mini‐review, I will try to introduce novel roles of OPC in the developing and damaged brain, focusing on the reciprocal crosstalk between OPC and vascular cells, as well as neurons.