bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEMORRHAGIC VASCULITIS AND RETINOPATHY HERALDING AS AN EARLY SIGN OF BACTERIAL ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION
Authors: Conrady Christopher D. , Feistmann Jonathan A. , Roller Aaron B. , Boldt H. Culver , Shakoor Akbar 
Published: June 2017

Purpose:
To describe a case series of postintravitreal injection, bacterial endophthalmitis heralded by hemorrhagic retinal vasculitis.

Methods:
Observational case series of three patients with a history of intravitreal injections for age-related macular degeneration at a tertiary referral center who presented with vision changes and eye pain that were eventually found to have bacterial endophthalmitis. Clinical course was then followed.

Results:
All patients developed bacterial endophthalmitis and hemorrhagic retinal vasculitis.

Conclusion:
These three cases highlight the importance of hemorrhagic retinal vasculitis as the presenting fundus finding of bacterial endophthalmitis and that this finding in a postinjection patient should be treated as endophthalmitis until proven otherwise.
Feasibility and Acceptability of the Use of Patient-Reported Outcome Measures in the Delivery of Nurse-Led, Supportive Care to Women With Cervical Cancer
Authors: Kotronoulas Grigorios , O’Brien Fran , Simpson Mhairi F. , Maguire Roma 
Published: June 2017

Purpose/Aims:
Patient-reported outcome measures (PROMs) can be effectively used to uncover the unmet needs of women with cervical cancer for supportive care. Our aim was to explore the feasibility and acceptability of PROM-driven, nurse-led consultations to enhance delivery of supportive care to women with cervical cancer during active anticancer treatment.

Design:
A 2-phased, mixed-method prospective study was conducted. Main research variables included feasibility and acceptability parameters of the trialed intervention.

Methods:
Preconsultation PROM data were collected during 3 consecutive monthly consultations and used by the gynecology cancers nurse specialist (CNS) to deliver personalized supportive care. The problem checklist and Cervical Cancer Concerns Questionnaire were used to aid data collection.

Findings:
Because of considerable recruitment challenges, a recruitment rate of 27% (3/11 patients) was achieved. Two patients completed all 3 study assessments. Seven in-clinic patient assessments were performed over 6 months. The study participants praised the opportunity for dedicated time for patients to raise concerns and for the CNS to provide sensitive and personalized support.

Conclusion:
Women with cervical cancer perceive important benefits from participating in PROM-driven, time-protected sessions with their CNS. Our findings provide tentative evidence to support the feasibility and acceptability of this intervention model and warrant future confirmation.

Implications for Practice:
3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations
Authors: Andronov Leonid , Michalon Jonathan , Ouararhni Khalid , Orlov Igor , Hamiche Ali , Vonesch Jean-Luc , Klaholz Bruno P. 
Published: June 2017

AbstractSingle-molecule localization microscopy (SMLM) can play an important role in integrated structural biology approaches for example at the interface of cryo electron microscopy (cryo-EM), X-ray crystallography, NMR and fluorescence imaging to identify, localize and determine the 3D structure of cellular structures. While many tools exist for the 3D analysis and visualisation of crystal or cryo-EM structures little exists for 3D SMLM data which can provide fascinating insights but are particularly challenging to analyze in three dimensions especially in a dense cellular context. We developed 3DClusterViSu, a method based on 3D Voronoi tessellations that allows local density estimation, segmentation & quantification of 3D SMLM data and visualization of protein clusters within a 3D tool. We show its robust performance on microtubules and histone proteins H2B and CENP-A with distinct spatial distributions. 3DClusterViSu will favor multi-scale and multi-resolution synergies to allow integrating molecular and cellular levels in the analysis of macromolecular complexes.
Early warning signals regarding environmental suitability in theDrosophilaantenna
Authors: Rong Haoyang , Das Prithwiraj , Lube Adalee , Yang David , Saha Debajit , Ben-Shahar Yehuda , Raman Baranidharan 
Published: June 2017

HighlightsA novel geotaxis assay showed high intensity odorant exposures are harmful to fliesRepulsion at high odor intensities can be a protective mechanismOlfactory receptor neuron (ORN) excitability abruptly changes with odor intensityA linear combination of ORN activities can robustly predict intensity-dependent behavioral repulsionSummaryThe olfactory system is uniquely positioned to warn an organism of environmental threats. Whether and how it encodes such information is not understood. Here, we examined this issue in the fruit flyDrosophila melanogaster.We found that intensity-dependent repulsion to chemicals safeguarded flies from harmful, high-intensity vapor exposures. To understand how sensory input changed as the odor valence switched from innocuous to threatening, we recorded from olfactory receptor neurons (ORNs) in the fly antenna. Primarily, we observed two response non-linearities: recruitment of non-active ORNs at higher intensities, and abrupt transitions in neural excitability from regular spiking to high-firing oscillatory regime. Although non-linearities observed in any single ORN was not a good indicator, a simple linear combination of firing events from multiple neurons provided robust recognition of threating/repulsive olfactory stimuli. In sum, our results reveal how information necessary to avoid environmental threats may also be encoded in the insect antenna.
Unfolding the hippocampus: an intrinsic coordinate system for subfield segmentations and quantitative mapping
Authors: DeKraker Jordan , Ferko Kayla M. , Lau Jonathan C. , Köhler Stefan , Khan Ali R. 
Published: June 2017

AbstractThe hippocampus, like the neocortex, has a morphological structure that is complex and variable in its folding pattern, especially in the hippocampal head. The current study presents a computational method to unfold hippocampal grey matter, with a particular focus on the hippocampal head where complexity is highest due to medial curving of the structure and the variable presence of digitations. This unfolding was performed on segmentations from high-resolution, T2-weighted 7T MRI data from 12 healthy participants and one surgical patient with epilepsy whose resected hippocampal tissue was used for histological validation. We traced a critical hippocampal component, the hippocampal sulcus and stratum radiatum, lacunosum moleculaire, (SRLM) in these images, then employed user-guided semi-automated techniques to detect and subsequently unfold the surrounding hippocampal grey matter. This unfolding was performed by solving Laplace’s equation in three dimensions of interest (long-axis, proximal-distal, and laminar). The resulting ‘unfolded coordinate space’ provides an intuitive way of mapping the hippocampal subfields in 2D space (long-axis and proximal-distal), such that similar borders can be applied in the head, body, and tail of the hippocampus independently of variability in folding. This unfolded coordinate space was employed to map intracortical myelin and thickness in relation to subfield borders, which revealed intracortical myelin differences that closely follow the subfield borders used here. Examination of a histological sample from a patient with epilepsy reveals that our unfolded coordinate system shows biological validity, and that subfield segmentations applied in this space are able to capture features not seen in manual tracing protocols.Research highlightsSRLM in hippocampal head consistently detected with 7T, T2 isotropic MRIHippocampal grey matter unfolded using Laplace’s equation in 3DIntracortical myelin and thickness mapped in unfolded coordinate spaceUnfolded subfields capture critical structural regularities and agree with histology
Unleashing natural competence inLactococcus lactisby induction of the competence regulator ComX
Authors: Mulder Joyce , Wels Michiel , Kuipers Oscar P. , Kleerebezem Michiel , Bron Peter A. 
Published: June 2017

AbstractIn biotechnological work horses likeStreptococcus thermophilusandBacillus subtilisnatural competence can be induced, which facilitates genetic manipulation of these microbes. However, in strains of the important dairy starterLactococcus lactisnatural competence has not been established to date. However,in silicoanalysis of complete genome sequences of 43L. lactisstrains revealed complete late-competence gene-sets in 2L. lactissubspeciescremorisstrains (KW2 and KW10) and 8L. lactissubspecieslactisstrains, including the model strain IL1403 and the plant-derived strain KF147. The remainder of the strains, including all dairy isolates, displayed genomic decay in one or more of the late competence genes. Nisin-controlled expression of the competence regulatorcomXinL. lactissubsp.lactisKF147 resulted in the induction of expression of the canonical competence regulon, and elicited a state of natural competence in this strain. By contrast,comXexpression inL. lactisNZ9000, predicted to encode an incomplete competence gene-set, failed to induce natural competence. Moreover, mutagenesis of thecomEA-ECoperon in strain KF147, abolished thecomXdriven natural competence, underpinning the involvement of the competence machinery. Finally, introduction of nisin-induciblecomXexpression intonisRK-harboring derivatives of strains IL1403 and KW2 allowed the induction of natural competence also in these strains, expanding this phenotype to otherL. lactisstrains of both subspecies.Significance statementSpecific bacterial species are able to enter a state of natural competence in which DNA is taken up from the environment, allowing the introduction of novel traits. Strains of the speciesLactococcus lactisare very important starter cultures for the fermentation of milk in the cheese production process, where these bacteria contribute to the flavor and texture of the end-product. The activation of natural competence in this industrially relevant organism can accelerate research aiming to understand industrially relevant traits of these bacteria, and can facilitate engineering strategies to harness the natural biodiversity of the species in optimized starter strains.
Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention
Authors: van Es D.M. , Theeuwes J. , Knapen T. 
Published: June 2017

AbstractSpatial attention changes the sampling of visual space. Behavioral studies suggest that feature-based attention modulates this resampling to optimize the attended feature’s sampling. We investigate this hypothesis by estimating spatial sampling in visual cortex while independently varying both feature-based and spatial attention.Our results show that spatial and feature-based attention interacted: resampling of visual space depended on both the attended location and feature (color vs. temporal frequency). This interaction occurred similarly throughout visual cortex, regardless of an area’s overall feature preference. However, the interaction did depend on spatial sampling properties of voxels that prefer the attended feature. These findings are parsimoniously explained by variations in the precision of an attentional gain field.Our results demonstrate that the deployment of spatial attention is tailored to the spatial sampling properties of units that are sensitive to the attended feature.
Just One Brain Activity
Authors: Tozzi Arturo , Peters James F. 
Published: June 2017

ABSTRACTThe term brain activity refers to a wide range of mental faculties that can be assessed either on anatomical/functional micro-, meso- and macro-spatiotemporal scales of observation, or on intertwined levels with mutual interactions. Here we show, based on novel topological findings, how every brain activity encompassed in a given anatomical or functional level necessarily displays a counterpart in others. Different brain activities are able to scatter, collide and combine, merging, condensing and stitching together in a testable and quantifiable way. We point out how, despite their local cortical functional differences, all the mental processes, from perception to emotions, from cognition to mind wandering, may be reduced to a single, general brain activity that takes place in dimensions higher than the classical 3D plus time. In physics, the term duality refers to the case where two seemingly different systems turn out to be equivalent. Our framework permits a topological duality among different brain activities and neuro-techniques, because it holds for all the types of spatio-temporal nervous functions, independent of their cortical location, inter- and intra-level relationships, strength, magnitude and boundaries.
Study on Lean Six Sigma frameworks: a critical literature review
Authors: Raval Shruti J. , Kant Ravi 
Published: June 2017

Purpose
The literature in the field of Lean Six Sigma (LSS) is escalating with frameworks, but, till date, no effort has been made in existing literature to critically reviewing LSS frameworks. The aim of this paper is to investigate the literature about Lean, Six Sigma and LSS frameworks and critically reviewing the existing literature over numerous parameters.

Design/methodology/approach
This study focuses on a literature review of Lean, Six Sigma and LSS frameworks. The time span of this analysis is 30 years. The analysis is restricted to searching online databases such as Elsevier Science direct, Taylor and Francis, Emerald, Springer link, Wiley Inter-Science and Inder-Science. A total number of 58 frameworks have been used as sample size for this study. The study focuses on reviewing these 58 frameworks based on measures such as the novelty of frameworks, source of frameworks, framework verification, approach of verification and identification of vital elements/tools/constructs of frameworks and lastly comparative analysis of all these 58 frameworks

Findings
The analysis has identified major discrepancy such as laxity of researcher toward utilizing existing frameworks, lack of participation of practitioners and consultants in the development of LSS frameworks, and the elements/constructs used in structuring the frameworks are highly incoherent. Higher proportions of frameworks are verified through various modes of verification such as survey, case study, simulation, which encourages other researchers for applicability of the frameworks. Case study is found most popular research design method for verification of frameworks. Various frameworks are highly abstract or superficial. Some of the frameworks do not show how each construct/element are related to implementation in the organization. Out of 58 frameworks, the only single framework is highly comprehensive. A coherent framework for LSS is still lacking.

Research limitations/implications
This analysis is limited to peer review articles from Elsevier Science direct, Taylor and Francis, Emerald, Springer link, Wiley Inter-Science and Inder-Science databases and contains the search keywords in title only.

Originality/value
This study is first of its kind attempt, making an effort to the knowledge of the authors to critically review Lean, Six Sigma and LSS frameworks. This analysis will assist to recognize the LSS filed trends and framework applicability.
Lean production in agribusiness organizations: multiple case studies in a developing country
Authors: Satolo Eduardo Guilherme , Hiraga Laiz Eritiemi de Souza , Goes Gustavo Antiqueira , Lourenzani Wagner Luiz 
Published: June 2017

Purpose
This paper aims to conduct case studies in companies of different branches of the agribusiness sector to analyze the degree of adherence to lean production system, considering the use of techniques and tools, and how the specificities of the agribusiness system work.

Design/methodology/approach
By contributing to the refinement of the theory, multiple type case studies were conducted in eight agribusiness units from different branches by applying structured interviews, on-site visits and document analysis. The comparative analysis of the cases occurred focusing on the degree of adherence to lean production system; use of techniques and tools; and influence of the specificities of agribusiness systems.

Findings
The adoption of lean production system occurs as an improvement mechanism of organizational performance. However, it is necessary to advance in the formalization of the actions, which need to encourage the creation of new leaders who spread the organizational philosophy. When comparing the degree of adherence to lean production with the use of techniques and tools, it was observed that there is no direct relationship, indicating that each organization should select only the techniques and tools that will improve their own organizational performance. At last, the specific characteristics of seasonality of consumption, quality and health surveillance and sociological aspects of the food have high influence on surveyed agribusiness systems, and its effects can be minimized by the techniques and tools associated with lean production system.

Research limitations/implications
The analysis is valid for the universe investigated due to the specific characteristic of the case study.

Originality/value
The literature regarding the lean production philosophy is vast; however, the agribusiness segment, one of the major sectors of the global economy, features a large gap in literature. This study is one of the first original papers to report this reality.
Different departments, different drivers
Authors: Guo Lan , Tobias Jutta , Bendoly Elliot , Hu Yuming 
Published: June 2017

PurposeThe purpose of this paper is to examine the antecedents and performance consequences of voluntary information exchange between the production and sales functions.Design/methodology/approachBuilding on the motivation-opportunity-ability framework, the authors first posit a general model for bilateral information exchange across functional levels. The innovation presented in this model consists in allowing both sides of such an exchange (e.g. production-to-sales and sales-to-production) to differ in the perceived adequacy of information they receive. The two sides can also differ in terms of how their motivation and ability impact that adequacy. To test the model, the authors make use of survey responses and objective data from sales, production and executive managers of 182 Chinese manufacturers.FindingsAnalysis of the sample shows that the sales-to-production exchange has a smaller estimated performance effect than the production-to-sales exchange. Although shared opportunity is important in predicting both sides of the exchange, the measure of motivation appears to only significantly impact the sales-to-production exchange. In contrast, the measure of ability only appears to significantly affect the production-to-sales exchange.Research limitations/implicationsAlthough limited to a regional context, differences in information-sharing drivers on the two sides of production-sales dyads pose strong implications that may be generalizable.Practical implicationsSpecifically, these findings suggest alternative approaches and foci for resource investment that higher level managers can leverage in developing more effective cross-functional work settings.Originality/valueThis study differentiates itself from extant literature on information sharing by focusing on cross-functional (vs intra-functional) and voluntary (vs routine) information exchange.
Domestic tourists’ mind-set towards responsible tourism management: a case study on Cox’s Bazar, Bangladesh
Authors: Amin Mohammad Ruhual 
Published: June 2017

PurposeNotwithstanding been a significant stakeholder in the sustainable and responsible tourism (RT) development and management process, worldwide very few studies exclusively investigated tourists’ attitudes towards them. Moreover, studies are especially missing for developing and least developed countries where domestic tourism market is more significant than international market. Besides, in Bangladesh, there is no study as yet which aimed to identify domestic tourists’ attitudes towards responsible tourism management (RTM) and to its triple bottom line (TBL) components. So, the purpose of this paper is to fill these gaps, contributing thus to the existing RTM literature.Design/methodology/approachAfter conducting extensive literature review, this study followed both the exploratory (in-depth interview) and single cross-sectional descriptive (survey) research designs. Further, this study used descriptive statistics (frequency distribution analysis) and multivariate dependence data analysis technique (multiple regression analysis) to analyse the data collected from the 385 sample respondents through systematic random sampling.FindingsBased on the findings, the present study argues, Bangladeshi tourists have positive attitudes towards each of the TBL components and to RTM, however, there is scope for further improvement. This study also suggests that there is a close link between tourists’ attitudes and their socio-demographic characteristics.Originality/valueWith the support and reference to this study, destination management organisations can work on each of the TBL components to enhance Bangladeshi tourists’ positive attitudes towards RT practices at Cox’s Bazar (CB). Moreover, this study on CB, Bangladesh also contributes to the RTM literature and minimises the known literature gap for developing countries.
Examining workplace bullying measurement using item response theory
Authors: Caponecchia Carlo , Costa Daniel S.J. 
Published: June 2017

Purpose
The purpose of this paper is to examine aspects of how workplace bullying is identified by the Negative Acts Questionnaire-Revised (NAQ-R), with a focus on the appropriateness of its response scale using item response theory (IRT).

Design/methodology/approach
IRT, in which the probability of a particular item response reflects an underlying latent variable, was used to examine NAQ-R responses from a sample of 1,173 Australian public servants (Study 1), and a representative UK data set (n=3,494; Study 2).

Findings
Results indicated that problems with the response scale appear to be due to the inclusion of the abstract “now and then” option amongst concrete time options (“never”, “now and then”, “monthly”, “weekly” and “daily”). These results were replicated in Study 2, providing evidence of the robustness of the findings, and suggesting the observations are not sample specific.

Research limitations/implications
This work has implications for methods employed to identify and measure workplace bullying in research and organisational practice. Inconsistent endorsement of response scale options is a concern when total scores are calculated, or when a number of behaviours being experienced with a particular frequency on the response scale are taken as an indication of bullying having occurred.

Originality/value
Examining and refining the manner in which workplace bullying is indexed is important for identifying and managing workplace risks to health, safety and well-being.