bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes
Authors: Bonham Luke W. , Evans Daniel S. , Liu Yongmei , Cummings Steven R. , Yaffe Kristine , Yokoyama Jennifer S. 
Published: January 2018

Background/Rationale: Experimental studies support the role of neurotransmitter genes in dementia risk, but human studies utilizing single variants in candidate genes have had limited success. Methods: We used the gene-based testing program Versatile Gene-based Association Study to assess whether aggregate variation across 6 neurotransmitter pathways influences risk of cognitive decline in 8159 cognitively normal elderly (≥65 years old) adults from 3 community-based cohorts. Results: Common genetic variation in GNG4 and KCNQ2 was associated with cognitive decline. In human brain tissue data sets, both GNG4 and KCNQ2 show higher expression in hippocampus relative to other brain regions; GNG4 expression decreases with advancing age. Both GNG4 and KCNQ2 show highest expression in fetal astrocytes. Conclusion: Genetic variation analyses and gene expression data suggest that GNG4 and KCNQ2 may be associated with cognitive decline in normal aging. Gene-based testing of neurotransmitter pathways may confirm and reveal novel risk genes in future studies of healthy cognitive aging.
Comparative Evaluations of Randomly Selected Four Point-of-Care Glucometer Devices in Addis Ababa, Ethiopia
Authors: Wolde Mistire , Tarekegn Getahun , Kebede Tedla 
Published: January 2018

Background: Point-of-care glucometer (PoCG) devices play a significant role in self-monitoring of the blood sugar level, particularly in the follow-up of high blood sugar therapeutic response. The aim of this study was to evaluate blood glucose test results performed with four randomly selected glucometers on diabetes and control subjects versus standard wet chemistry (hexokinase) methods in Addis Ababa, Ethiopia. Method: A prospective cross-sectional study was conducted on randomly selected 200 study participants (100 participants with diabetes and 100 healthy controls). Four randomly selected PoCG devices (CareSens N, DIAVUE Prudential, On Call Extra, i-QARE DS-W) were evaluated against hexokinase method and ISO 15197:2003 and ISO 15197:2013 standards. Results: The minimum and maximum blood sugar values were recorded by CareSens N (21 mg/dl) and hexokinase method (498.8 mg/dl), respectively. The mean sugar values of all PoCG devices except On Call Extra showed significant differences compared with the reference hexokinase method. Meanwhile, all four PoCG devices had strong positive relationship (>80%) with the reference method (hexokinase). On the other hand, none of the four PoCG devices fulfilled the minimum accuracy measurement set by ISO 15197:2003 and ISO 15197:2013 standards. In addition, the linear regression analysis revealed that all four selected PoCG overestimated the glucose concentrations. Conclusions: The overall evaluation of the selected four PoCG measurements were poorly correlated with standard reference method. Therefore, before introducing PoCG devices to the market, there should be a standardized evaluation platform for validation. Further similar large-scale studies on other PoCG devices also need to be undertaken.
The chronic ischaemic cardiovascular disease ESC Pilot Registry: Results of the six-month follow-up
Authors: Komajda Michel , Kerneis Mathieu , Tavazzi Luigi , Balanescu Serban , Cosentino Francesco , Cremonesi Alberto , Ferrari Roberto , Kownator Serge , Szwed Hanna , Mintale Iveta , Olivari Zoran , Rittger Harald , Shlyakhto Evgeny V , Slapikas Rimvydas , Steg Philippe Gabriel , Valgimigli Marco , Van Belle Eric , Tsioufis Konstantinos , Majda Wojciech , Laroche Cécile , Maggioni Aldo P 
Published: January 2018

Aim Chronic ischaemic cardiovascular disease (CICD) remains a leading cause of morbidity and mortality worldwide. The CICD Pilot Registry enrolled 2420 patients across 10 European Society of Cardiology countries prospectively to describe characteristics, management strategies and clinical outcomes in this setting. We report here the six-month outcomes. Methods and results From the overall population, 2203 patients were analysed at six months. Fifty-eight patients (2.6%) died after inclusion; 522 patients (23.7%) experienced all-cause hospitalisation or death. The rate of prescription of angiotensin-converting enzyme inhibitors, beta-blockers and aspirin was mildly decreased at six months (all P < 0.02). Patients who experienced all-cause hospitalisation or death were older, more often had a history of non-ST-segment elevation myocardial infarction, of chronic kidney disease, peripheral revascularisation and/or chronic obstructive pulmonary disease than those without events. Independent predictors of all-cause mortality/hospitalisation were age (hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.07–1.27) per 10 years, and a history of previous peripheral revascularisation (HR 1.45, 95% CI 1.03–2.03), chronic kidney disease (HR 1.31, 95% CI 1.0–1.68) or chronic obstructive pulmonary disease (HR 1.42, 95% CI 1.06–1.91, all P < 0.05). We observed a higher rate of events in eastern, western and northern countries compared to southern countries and in cohort 1. Conclusion In this contemporary European registry of CICD patients, the rate of severe clinical outcomes at six months was high and was influenced by age, heart rate and comorbidities. The medical management of this condition remains suboptimal, emphasising the need for larger registries with long-term follow-up. Ad-hoc programmes aimed at implementing guidelines adherence and follow-up procedures are necessary, in order to improve quality of care and patient outcomes.
What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol
Authors: Goulas Anaïs , Livoreil Barbara , Grall Nathalie , Benoit Pierre , Couderc-Obert Céline , Dagot Christophe , Patureau Dominique , Petit Fabienne , Laouénan Cédric , Andremont Antoine 
Published: January 2018

Abstract
Background
Antibiotic treatments are indispensable for human and animal health. However, the heavy usage of antibiotics has led to the emergence of resistance. Antibiotic residues, antibiotic-resistant bacteria and genes are introduced into the terrestrial and aquatic environments via application of human and animal wastes. The emergence and the spread of antibiotic resistance in environmental reservoirs (i.e., soil, water, wildlife) threatens the efficacy of all antibiotics. Therefore, there is an urgent need to determine what effective solutions exist to minimize the dissemination of antibiotic resistance in the environment. The aim of this article is to describe the protocol of a systematic review of the literature considering these solutions.

Methods
The primary questions addressed by the systematic review protocol are: how antibiotic resistance in the environment is impacted by changes in practice concerning (i) the use of antibiotics, (ii) the management of wastes or (iii) the management of the natural compartment. Bibliographic searches will be made in eleven publication databases as well as in specialist databases. Grey literature will also be searched. Articles will be screened regarding the inclusion and exclusion criteria at title, abstract and full-text levels. Studies where a causal relationship between the intervention and the outcome is made will be retained. After critical appraisal, data from the selected articles will be extracted and saved in a database validated by the expert panel. Study quality will be assessed by critical appraisal. Data will be compiled into a qualitative synthesis. If data availability and quality allow it, a quantitative synthesis will be carried out.
Improvement in Overall Survival With Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Authors: Siegel David S. , Dimopoulos Meletios A. , Ludwig Heinz , Facon Thierry , Goldschmidt Hartmut , Jakubowiak Andrzej , San-Miguel Jesus , Obreja Mihaela , Blaedel Julie , Stewart A. Keith 
Published: January 2018

Purpose In the ASPIRE study of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide plus dexamethasone (Rd) in patients with relapsed or refractory multiple myeloma, progression-free survival was significantly improved in the carfilzomib group (hazard ratio, 0.69; two-sided P < .001). This prespecified analysis reports final overall survival (OS) data and updated safety results. Patients and Methods Adults with relapsed multiple myeloma (one to three prior lines of therapy) were eligible and randomly assigned at a one-to-one ratio to receive KRd or Rd in 28-day cycles until withdrawal of consent, disease progression, or occurrence of unacceptable toxicity. After 18 cycles, all patients received Rd only. Progression-free survival was the primary end point; OS was a key secondary end point. OS was compared between treatment arms using a stratified log-rank test. Results Median OS was 48.3 months (95% CI, 42.4 to 52.8 months) for KRd versus 40.4 months (95% CI, 33.6 to 44.4 months) for Rd (hazard ratio, 0.79; 95% CI, 0.67 to 0.95; one-sided P = .0045). In patients receiving one prior line of therapy, median OS was 11.4 months longer for KRd versus Rd; it was 6.5 months longer for KRd versus Rd among patients receiving ≥ two prior lines of therapy. Rates of treatment discontinuation because of adverse events (AEs) were 19.9% (KRd) and 21.5% (Rd). Grade ≥ 3 AE rates were 87.0% (KRd) and 83.3% (Rd). Selected grade ≥ 3 AEs of interest (grouped terms; KRd v Rd) included acute renal failure (3.8% v 3.3%), cardiac failure (4.3% v 2.1%), ischemic heart disease (3.8% v 2.3%), hypertension (6.4% v 2.3%), hematopoietic thrombocytopenia (20.2% v 14.9%), and peripheral neuropathy (2.8% v 3.1%). Conclusion KRd demonstrated a statistically significant and clinically meaningful reduction in the risk of death versus Rd, improving survival by 7.9 months. The KRd efficacy advantage is most pronounced at first relapse.
Cholangiocarcinoma With FGFR Genetic Aberrations: A Unique Clinical Phenotype
Authors: Jain Apurva , Borad Mitesh J. , Kelley Robin Kate , Wang Ying , Abdel-Wahab Reham , Meric-Bernstam Funda , Baggerly Keith A. , Kaseb Ahmed Omar , Al-shamsi Humaid O. , Ahn Daniel H. , DeLeon Thomas , Bocobo Andrea Grace , Bekaii-Saab Tanios , Shroff Rachna T. , Javle Milind 
Published: January 2018

Purpose FGFR genetic aberrations (GAs) occur in an estimated 10% to 16% of intrahepatic cholangiocarcinomas (CCAs). The natural history of CCA with FGFR GAs, the prognostic role of coexisting GAs, and the outcome with FGFR-targeted inhibitors are unknown. Patients and Methods Patients with CCA with FGFR GAs were identified using next-generation sequencing or fluorescence in situ hybridization from four tertiary cancer centers and compared with FGFR wild-type counterparts. Data reviewed included demographic, treatment, overall survival (OS), and GA data. Fisher’s exact test, Kaplan-Meier plots, and log-rank tests were used for statistical analysis. Results Three hundred seventy-seven patients with CCA were identified, and 95 had FGFR GAs. FGFR2 GA was most common (n = 74, with 63 fusions) and seen in intrahepatic CCA. In patients with CCA, FGFR GAs occurred more frequently in younger patients (≤ 40 years; 20%) compared with older patients (> 40 years; 6.7%; P < .001), presented at an earlier stage (TNM stage I/II v III/IV: 35.8% v 22%, respectively; P = .001), and were associated with a longer OS compared with patients without FGFR GAs (37 v 20 months, respectively; P < .001). This difference remained significant after excluding 36 patients treated with FGFR inhibitors. There was no OS difference ( P = .60) between CCA with FGFR2 fusions (n = 63) versus other FGFR GAs (n = 29). Patients with FGFR GAs had a better OS with FGFR-targeted therapy compared with standard treatment ( P = .01). BAP1 mutation was the most common coexisting mutation without prognostic impact, whereas TP53 ( P = .04) and CDKN2A/B ( P = .04) were correlated with a shorter OS. Conclusion CCA with FGFR GAs represents a unique subtype occurring in younger patients with an indolent disease course. FGFR-targeted therapy may have a positive impact on OS in this subgroup.
New Modalities for the Administration of Inhaled Nitric Oxide in Intensive Care Units After Cardiac Surgery or for Neonatal Indications: A Prospective Observational Study
Authors: Gaudard Philippe , Barbanti Claudio , Rozec Bertrand , Mauriat Philippe , M’rini Mimoun , Cambonie Gilles , Liet Jean Michel , Girard Claude , Leger Pierre Louis , Assaf Ziad , Damas Pierre , Loron Gauthier , Lecourt Laurent , Amour Julien , Pouard Philippe 
Published: January 2018

BACKGROUND:
Nitric oxide (NO) has a well-known efficacy in pulmonary hypertension (PH), with wide use for 20 years in many countries. The objective of this study was to describe the current use of NO in real life and the gap with the guidelines.

METHODS:
This is a multicenter, prospective, observational study on inhaled NO administered through an integrated delivery and monitoring device and indicated for PH according to the market authorizations. The characteristics of NO therapy and ventilation modes were observed. Concomitant pulmonary vasodilator treatments, safety data, and outcome were also collected. Quantitative data are expressed as median (25th, 75th percentile).

RESULTS:
Over 1 year, 236 patients were included from 14 equipped and trained centers: 117 adults and 81 children with PH associated with cardiac surgery and 38 neonates with persistent PH of the newborn. Inhaled NO was initiated before intensive care unit (ICU) admission in 57%, 12.7%, and 38.9% with an initial dose of 10 (10, 15) ppm, 20 (18, 20) ppm, and 17 (11, 20) ppm, and a median duration of administration of 3.9 (1.9, 6.1) days, 3.8 (1.8, 6.8) days, and 3.1 (1.0, 5.7) days, respectively, for the adult population, pediatric cardiac group, and newborns. The treatment was performed using administration synchronized to the mechanical ventilation. The dose was gradually decreased before withdrawal in 86% of the cases according to the usual procedure of each center. Adverse events included rebound effect for 3.4% (95% confidence interval [CI], 0.9%–8.5%) of adults, 1.2% (95% CI, 0.0%–6.7%) of children, and 2.6% (95% CI, 0.1%–13.8%) of neonates and methemoglobinemia exceeded 2.5% for 5 of 62 monitored patients. Other pulmonary vasodilators were associated with NO in 23% of adults, 95% of children, and 23.7% of neonates. ICU stay was respectively 10 (6, 22) days, 7.5 (5.5, 15) days, and 9 (8, 15) days and ICU mortality was 22.2%, 6.2%, and 7.9% for adults, children, and neonates, respectively.

CONCLUSIONS:
This study confirms the safety of NO therapy in the 3 populations with a low rate of rebound effect. Gradual withdrawal of NO combined with pulmonary vasodilators are current practices in this population. The use of last-generation NO devices allowed good compliance with recommendations.
Bayesian Nonparametric Customer Base Analysis with Model-Based Visualizations
Authors: Dew Ryan , Ansari Asim 
Published: January 2018

Marketing managers are responsible for understanding and predicting customer purchasing activity. This task is complicated by a lack of knowledge of all of the calendar time events that influence purchase timing. Yet, isolating calendar time variability from the natural ebb and flow of purchasing is important for accurately assessing the influence of calendar time shocks to the spending process, and for uncovering the customer-level purchasing patterns that robustly predict future spending. A comprehensive understanding of purchasing dynamics therefore requires a model that flexibly integrates known and unknown calendar time determinants of purchasing with individual-level predictors such as interpurchase time, customer lifetime, and number of past purchases. In this paper, we develop a Bayesian nonparametric framework based on Gaussian process priors, which integrates these two sets of predictors by modeling both through latent functions that jointly determine purchase propensity. The estimates of these latent functions yield a visual representation of purchasing dynamics, which we call the model-based dashboard, that provides a nuanced decomposition of spending patterns. We show the utility of this framework through an application to purchasing in free-to-play mobile video games. Moreover, we show that in forecasting future spending, our model outperforms existing benchmarks. Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1050 .
Public Housing in Fascist Rome: A European Perspective
Authors: Bodenschatz Harald 
Published: January 2018

This article discusses the role of housing in the political agenda of dictatorial regimes in the interwar period, in particular in the agenda of Italian Fascism. It brings about the factors that contributed to make public housing a key component in securing the support of the middle classes in the creation of social consensus necessary for the preservation of Mussolini’s dictatorial regime. The maps advances a typological mapping of housing complexes for Mussolini’s Rome, which illustrates a policy based on the urbanization of the middle classes, and the de-urbanization of the urban poor.
Perang dan Kekerasan Atas Nama Agama dalam Wacana Ilmiah
Authors: Hamsah Ustadi 
Published: January 2018

Religion always offers both peace and steady, but negates war and violence. In the history of human civilization, religion is present in the course of human life. Religion, in one side, serves as a cure in the hard situation of human history such as starvation, death and disaster, however, either war or violence is ironically triggered by human’s view on religion to justify violence in the name of religion. The phenomenon signifies the bold topic of human history, religion and violence. Applying the sociology of religion approach, this paper tries to explore how the contruction of human thought is present related to their views on religion, and how the position of religion in the context of war and violence in the lines of their history.
Belajar Toleransi Beragama di Lereng Menoreh Kabupaten Magelang
Authors: Abdullah Nafilah 
Published: January 2018

This study aims to determine the slope of religious understanding Menoreh of religious about plurality and tolerance, and to know the attitude of religious tolerance in the slope Menoreh with people of other religions as well as to determine how the shape of religious Menoreh Magelang slope area facing intolerance that would undermine efforts religious tolerance are deeply embedded in the region?
Dialog Interreligius-Kultural dan Civil Religion (Studi atas Paguyuban Ngesti Tunggal (Pangestu)
Authors: Muryana Muryana 
Published: January 2018

The disaster is not only a mere natural occurrence, but also due to the lack of awareness and understanding of one's environmental problems. This paper will review the ecological values contained in the Qur'an. In fact, the Qur'an has given a stern warning of not doing mischief on earth. In this regard, within the certain limits, the query is how religion (Islam) providing ecological value to the whole community through the Koran? Applying semantic-hermeneutical approach, the research results the concept that has been introduced by the Qur'an with various forms and models of word. With some verses that describe the ecological problems, the formulation can be used as 'green religion', namely religion that requires people to practice Islam stressing the integral relationship between faith and the environment (all natural). Moral-ethical action is not only related to human relations, but also with nature.
Pesantren Waria Senin-Kamis Al-Fatah Yogyakarta: Sebuah Media Eksistensi Ekspresi Keberagamaan Waria
Authors: Safri Arif Nuh 
Published: January 2018

Religion certainly is present in every human being, because it is an natural tendency. The presence of God in every human being is a necessity. Nevertheless, religious expression and Godliness will always vary. The concept of religiosity and Godliness will differ between the chaplain, students, scholars, with criminals, thieves, pickpockets, prostitutes and transvestites. Each one is identical to the role and experience of its own. Therefore, awareness of the differences in the identification of religion and God, should make man more flexibility to appreciate other people's religiosity and Godliness, although others are emerging from marginal groups, or the offender is considered a sin, so that everyone is aware of and comfortable with undergoing road religion and the way the Lord each believed. Through this article, the author will present a descriptive pattern diversity ekspreif shemale Shemale on Mondays and Thursdays at Pesantren al-Fatah Yogyakarta. At least, the courage to hold these institutions, has become proof of the existence of transgender religious expression on the face of this earth, once negated that should not be considered pious people who claim to be religious and atheist.[Agama pasti hadir dalam diri setiap manusia, karena itu merupakan fitrah yang terbawa sejak lahir. Kehadiran Tuhan dalam diri setiap manusia adalah sebuah keniscayaan. Namun demikian, ekspresi keberagamaan dan kebertuhanan akan selalu berbeda-beda. Konsep keberagamaan dan kebertuhanan akan berbeda antara kiyai, santri, sarjana, dengan koruptor, pencuri, pencopet, pelacur dan waria. Masing-masing identik dengan peran dan pengalaman tersendiri. Oleh sebab itu, kesadaran akan perbedaan identifikasi agama dan Tuhan, seharusnya menjadikan manusia lebih leluasa untuk menghargai keberagamaan dan kebertuhanan orang lain, walaupun orang lain tersebut muncul dari kaum marginal, atau kaum yang dianggap pelaku dosa, sehingga setiap orang dengan sadar dan nyaman menjalani jalan agama dan jalan Tuhannya masing-masing yang diyakini. Melalui artikel ini, penulis akan memaparkan secara deskriptif pola ekspreif keberagamaan waria di Pesantren Waria Senin Kamis al-Fatah Yogyakarta. Setidaknya, keberanian mengadakan lembaga ini, sudah menjadi bukti eksistensi ekspresi keberagamaan waria di muka bumi ini, sekaligus menegasikan bahwa tidak harus orang yang dianggap saleh yang boleh beragama dan mengaku bertuhan.]
PENGARUH LINGKUNGAN SOSIAL TERHADAP MOTIVASI BERPRESTASI ANAK PANTI ASUHAN NURUL HAQ YOGYAKARTA
Authors: Annajah Ulfah , Falah Nailul 
Published: January 2018

Penelitian ini bertujuan untuk mengetahui berapa besar pengaruh lingkungan sosial terhadap motivasi berprestasi anak Panti Asuhan Nurul Haq Yogyakarta. Hipotesis yang diajukan dalam penelitian ini terdapat pengaruh yang signifikan antara lingkungan sosial dan motivasi berprestasi anak, semakin tinggi kualitas lingkungan sosial maka semakin tinggi pula motivasi berprestasi anak, sebaliknya semakin rendah kualitas lingkungan sosial anak, maka semakin rendah pula motivasi berprestasi anak. Penelitian ini menggunakan pendekatan kuantitatif. Subjek yang dilibatkan dalam penelitian ini berjumlah 96 anak. Anak diambil menggunakan teknik sampling jenuh. Alat pengumpul data menggunakan skala lingkungan sosial dan skala motivasi berprestasi. Analisis data menggunakan studi regresi sederhana dengan program SPSS 18.0 for Windows. Hasil penelitian ini menunjukan adanya korelasi yang positif antara lingkungan sosial dengan motivasi berprestasi anak. Besar korelasinya 0,443 dan sangat signifikan. Dengan adanya hubungan korelasi ini menunjukan bahwa antara lingkungan sosial dengan motivasi berprestasi ini saling berpengaruh satu sama lain. Berdasarkan hasil analisis hipotesis yang diajukan, maka hipotesis diterima, yakni terdapat pengaruh yang signifikan antara lingkungan sosial dengan motivasi berprestasi anak panti. Artinya semakin tinggi kualitas lingkungan sosial maka semakin tinggi motivasi berprestasi anak. Dalam penelitian ini lingkungan Sosial memberikan kontribusi sumbangan terhadap motivasi berprestasi sebesar 19,6 %, artinya masih ada 80,4 % faktor lain yang dapat mempengaruhi motivasi berprestasi. Kata Kunci: Lingkungan Sosial, Motivasi Berprestasi