bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between secondhand smoke exposure at home and cigarette gifting and sharing in Zhejiang, China: a repeat cross-sectional study
Authors: Xu Yue , Xu ShuiYang , Wu QingQing , Guo YuJie 
Published: March 2016

ObjectivesThe aims of the current study were to assess the prevalence of household cigarette gifting and sharing, and to evaluate the relationship between secondhand smoke (SHS) exposure, and cigarette gifting and sharing, in Zhejiang, China.DesignA repeat cross-sectional design.Setting10 sites in 5 cities in Zhejiang, China.ParticipantsTwo surveys were conducted with adults in Zhejiang, China, in 2010 (N=2112) and 2012 (N=2279), respectively. At both waves, the same questionnaire was used; respondents were asked questions on residence, number of family smokers, indoor smoking rules, household income and cigarette gifting and sharing.ResultsThe findings revealed that more than half of respondents’ families (54.50% in 2010, 52.79% in 2012) reported exposure to SHS. Many families (54.73% in 2010, 47.04% in 2012) shared cigarettes with others, and a minority (14.91% in 2010, 14.17% in 2012) reported their family giving cigarettes as a gift. There was a significant decrease in cigarette sharing from 2010 to 2012, irrespective of household with SHS exposure status; and the cigarette gifting was significantly decreased in household without SHS exposure.ConclusionsCompared to households without SHS exposure, the prevalence of cigarette gifting and sharing in households with SHS exposure was more obvious. Encouraging and promoting a smoke-free household environment is necessary to change public smoking customs in Zhejiang, China.
The denominator problem: national hospital quality measures for acute myocardial infarction
Authors: Bruckel Jeffrey , Liu Xiu , Hohmann Samuel F , Karson Andrew S , Mort Elizabeth , Shahian David M 
Published: March 2016

BackgroundNational Hospital Quality Measures (NHQM) should accurately reflect quality of care, as they increasingly impact reimbursement and reputation. However, similar to risk adjustment of outcomes measures, NHQM process measures pose unique methodological concerns, including lack of representativeness of the final denominator population after exclusions. This study determines population size and characteristics for each acute myocardial infarction (AMI) measure, reasons for exclusion from the measures, and variation in exclusion rates among hospitals.Methods and results163 144 discharges from 172 University HealthSystem Consortium hospitals between 2008-Q4 and 2013-Q3 were examined, including characteristics and propensity scores of included and excluded groups. Measure exclusions ranged from 17.8% (discharge aspirin) to 90.1% (percutaneous coronary intervention, PCI, within 90 min), with substantial variation across hospitals. Median annual denominator size (IQR) for PCI within 90 min was 28 (20, 44) at major teaching hospitals, versus 10 (0, 25) at non-teaching hospitals. Patients most likely to be excluded (in the 10th vs 1st propensity decile) were older (mean age (SD) of 78.1 (10.8) vs 50.3 (8.6) years), more likely to have Medicare (90.5% vs 0.9%), had more documented comorbidities (15.6 (4.6) vs 6.2 (2.5) hierarchical clinical condition categories) and higher admission mortality risk (Major or Extreme 80.9% vs 7.3%, respectively), and experienced higher inpatient mortality (10.0% vs 1.6%).ConclusionsExclusion from AMI measures varied substantially among hospitals, sample sizes were very small for some measures (PCI and ACE inhibitor measures) and measures often excluded high-risk populations. This has implications for the representativeness and comparability of the measures and provides insight for future measure development.
Don't Think, Just Feel the Music: Individuals with Strong Pavlovian-to-Instrumental Transfer Effects Rely Less on Model-based Reinforcement Learning
Authors: Sebold Miriam , Schad Daniel J. , Nebe Stephan , Garbusow Maria , Jünger Elisabeth , Kroemer Nils B. , Kathmann Norbert , Zimmermann Ulrich S. , Smolka Michael N. , Rapp Michael A. , Heinz Andreas , Huys Quentin J. M. 
Published: March 2016

Abstract
Behavioral choice can be characterized along two axes. One axis distinguishes reflexive, model-free systems that slowly accumulate values through experience and a model-based system that uses knowledge to reason prospectively. The second axis distinguishes Pavlovian valuation of stimuli from instrumental valuation of actions or stimulus–action pairs. This results in four values and many possible interactions between them, with important consequences for accounts of individual variation. We here explored whether individual variation along one axis was related to individual variation along the other. Specifically, we asked whether individuals' balance between model-based and model-free learning was related to their tendency to show Pavlovian interferences with instrumental decisions. In two independent samples with a total of 243 participants, Pavlovian–instrumental transfer effects were negatively correlated with the strength of model-based reasoning in a two-step task. This suggests a potential common underlying substrate predisposing individuals to both have strong Pavlovian interference and be less model-based and provides a framework within which to interpret the observation of both effects in addiction.
miR-181a negatively regulates NF-κB signaling and affects activated B-cell–like diffuse large B-cell lymphoma pathogenesis
Authors: Kozloski Goldi A. , Jiang Xiaoyu , Bhatt Shruti , Ruiz Jose , Vega Francisco , Shaknovich Rita , Melnick Ari , Lossos Izidore S. 
Published: March 2016

Key PointsmiR-181a regulates the NF-κB signaling pathway by targeting CARD11, NFKBIA, NFKB1, RELA/P65, and REL. miR-181a represses NF-κB signaling and decreases cell proliferation and survival most potently in the NF-κB dependent ABC-DLBCL subgroup.
Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice
Authors: Kitada Yoshihiko , Kajita Kazuo , Taguchi Koichiro , Mori Ichiro , Yamauchi Masahiro , Ikeda Takahide , Kawashima Mikako , Asano Motochika , Kajita Toshiko , Ishizuka Tatsuo , Banno Yoshiko , Kojima Itaru , Chun Jerold , Kamata Shotaro , Ishii Isao , Morita Hiroyuki 
Published: March 2016

Abstract
Sphingosine 1-phosphate (S1P) is known to regulate insulin resistance in hepatocytes, skeletal muscle cells, and pancreatic β-cells. Among its 5 cognate receptors (S1pr1–S1pr5), S1P seems to counteract insulin signaling and confer insulin resistance via S1pr2 in these cells. S1P may also regulate insulin resistance in adipocytes, but the S1pr subtype(s) involved remains unknown. Here, we investigated systemic glucose/insulin tolerance and phenotypes of epididymal adipocytes in high-fat diet (HFD)-fed wild-type and S1pr2-deficient (S1pr2−/−) mice. Adult S1pr2−/− mice displayed smaller body/epididymal fat tissue weights, but the differences became negligible after 4 weeks with HFD. However, HFD-fed S1pr2−/− mice displayed better scores in glucose/insulin tolerance tests and had smaller epididymal adipocytes that expressed higher levels of proliferating cell nuclear antigen than wild-type mice. Next, proliferation/differentiation of 3T3-L1 and 3T3-F442A preadipocytes were examined in the presence of various S1pr antagonists: JTE-013 (S1pr2 antagonist), VPC-23019 (S1pr1/S1pr3 antagonist), and CYM-50358 (S1pr4 antagonist). S1P or JTE-013 treatment of 3T3-L1 preadipocytes potently activated their proliferation and Erk phosphorylation, whereas VPC-23019 inhibited both of these processes, and CYM-50358 had no effects. In contrast, S1P or JTE-013 treatment inhibited adipogenic differentiation of 3T3-F442A preadipocytes, whereas VPC-23019 activated it. The small interfering RNA knockdown of S1pr2 promoted proliferation and inhibited differentiation of 3T3-F442A preadipocytes, whereas that of S1pr1 acted oppositely. Moreover, oral JTE-013 administration improved glucose tolerance/insulin sensitivity in ob/ob mice. Taken together, S1pr2 blockade induced proliferation but suppressed differentiation of (pre)adipocytes both in vivo and in vitro, highlighting a novel therapeutic approach for obesity/type 2 diabetes.
Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors
Authors: Vale-Costa Sílvia , Alenquer Marta , Sousa Ana Laura , Kellen Bárbara , Ramalho José , Tranfield Erin M. , Amorim Maria João 
Published: March 2016

ABSTRACT
Influenza A virus assembly is an unclear process, whereby individual virion components form an infectious particle. The segmented nature of the influenza A genome imposes a problem to assembly because it requires packaging of eight distinct RNA particles (vRNPs). It also allows genome mixing from distinct parental strains, events associated with influenza pandemic outbreaks. It is important to public health to understand how segmented genomes assemble, a process that is dependent on the transport of components to assembly sites. Previously, it has been shown that vRNPs are carried by recycling endosome vesicles, resulting in a change of Rab11 distribution. Here, we describe that vRNP binding to recycling endosomes impairs recycling endosome function, by competing for Rab11 binding with family-interacting proteins, and that there is a causal relationship between Rab11 ability to recruit family-interacting proteins and Rab11 redistribution. This competition reduces recycling sorting at an unclear step, resulting in clustering of single- and double-membraned vesicles. These morphological changes in Rab11 membranes are indicative of alterations in protein and lipid homeostasis during infection. Vesicular clustering creates hotspots of the vRNPs that need to interact to form an infectious particle.
Flowering, fruiting, seed germination and seedling growth of Macaranga gigantea
Authors: SUSANTO DWI , RUCHIYAT DADDY , SUTISNA MAMAN , AMIRTA RUDIANTO 
Published: March 2016

Susanto D, Ruchiyat D, Sutisna M, Amirta R. Flowering, fruiting, seed germination and seedling growth of MacarangaÂ gigantea. Biodiversitas 17: 192-199. The stages of flower and fruit development of Macaranga gigantea, its seed germination behaviorÂ in nature and from fruit harvesting, as well as the process of raising its seedlings in the laboratory were studied to determine theÂ potential for production of M. gigantea seedlings. Five reproductive trees of M. gigantea were chosen as sources of seed. To estimateÂ natural germination rates, four sample plots of 1 x 1 mÂ 2in four cardinal directions below the crown of every tree were set up. InÂ addition, dry and wet extraction processes were carried out to determine, which the more effective method for germination of M.Â gigantea seeds. The results showed that the time required from flower development to fruit ripening in M. gigantea flowers was 5-6Â months. The flower buds initiated in the dry season (August 2011). The germination in laboratory showed that the percentage and the rate of germination of the seeds extracted through the wet extraction process were higher than those extracted through the dry extraction process. The highest rate of germination planted on mushroom spawn waste media was the highest rate (0.36 ï‚±0.42%), followed by those planted on compost media (0.15ï‚±0.09%), top soil media (0.10ï‚±0.04%)Â and sand media (0.10ï‚±0.07%).
Sludge dewatering in a decanter centrifuge aided by cationic flocculant Praestol 855BS and essential oil of waste orange peels
Authors: Kowalczyk Anna , Piecuch Tadeusz 
Published: March 2016

Abstract
In the study the comparative analysis of test results of drainage of municipal wastewater sludge was conducted with the use of flocculant Praestol 855BS and the mixture of flocculant Praestol 855BS 50% + orange essential oil 50%, as the reagents supporting this process. It was also attempted to reduce unpleasant smells exuding from the drained sludge.
The process of drainage of municipal wastewater sludge was conducted in the laboratory setting centrifuge of MPW-350 type. The variable independent parameters were centrifugation time, centrifugation speed, dosage of flocculant Praestol 855BS as well as dosage of mixture in the proportion of flocculant Praestol 855BS (50%) + orange essential oil (50%). The following parameters were subject to assessment: water content in the sludge, dry mass content in the reflux as well as time of maintenance of the oil’s smell in the sludge. The conducted tests demonstrated that the orange essential oil has an impact on drop in resultant quality parameters of the drainage process of municipal wastewater sludge. Batching of the orange essential oil has an impact on considerable reduction of odours exuding from drained wastewater sludge, and thus on improvement of work conditions connected with operation of centrifugal separators. Bearing in mind both the efficient drainage process of wastewater sludge as well as simultaneous reduction of unpleasant smells exuding from the sludge during this process it is assumed and recommended to simultaneously apply both reagents, that is flocculant Praestol 855BS (50%) and orange essential oil, also in the volume of 50%.
Acoustic Nonlinearity Parameter B/A, Internal Pressure, and Acoustic Impedance Determined at Pressures up to 100 MPa for 1-Ethyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide
Authors: Zorębski Edward , Zorębski Michał , Dzida Marzena 
Published: March 2016

Abstract
The nonlinearity parameter B/A, internal pressure, and acoustic impedance are calculated for a room temperature ionic liquid, i.e. for 1-ethyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl] imide for temperatures from (288.15 to 318.15) K and pressures up to 100 MPa. The B/A calculations are made by means of a thermodynamic method. The decrease of B/A values with the increasing pressure is observed. At the same time B/A is temperature independent in the range studied. The results are compared with corresponding data for organic molecular liquids. The isotherms of internal pressure cross at pressure in the vicinity of 70 MPa, i.e. in this range the internal pressure is temperature independent.
Digital Synthesis of Sound Generated by Tibetan Bowls and Bells
Authors: Gołaś Andrzej , Filipek Roman 
Published: March 2016

Abstract
The aim of this paper is to present methods of digitally synthesising the sound generated by vibroacoustic systems with distributed parameters. A general algorithm was developed to synthesise the sounds of selected musical instruments with an axisymmetrical shape and impact excitation, i.e., Tibetan bowls and bells. A coupled mechanical-acoustic field described by partial differential equations was discretized by using the Finite Element Method (FEM) implemented in the ANSYS package. The presented synthesis method is original due to the fact that the determination of the system response in the time domain to the pulse (impact) excitation is based on the numerical calculation of the convolution of the forcing function and impulse response of the system. This was calculated as an inverse Fourier transform of the system’s spectral transfer function. The synthesiser allows for obtaining a sound signal with the assumed, expected parameters by tuning the resonance frequencies which exist in the spectrum of the generated sound. This is accomplished, basing on the Design of Experiment (DOE) theory, by creating a meta-model which contains information on its response surfaces regarding the influence of the design parameters. The synthesis resulted in a sound pressure signal in selected points in space surrounding the instrument which is consistent with the signal generated by the actual instruments, and the results obtained can improve them.
Aspasian Infidelities. On Aspasius’ Philosophical Background (EN I)
Authors: Mesquita António Pedro 
Published: March 2016

AbstractThe discussion on Aspasius’ philosophical background has benefited in recent years from a wide consensus. According to this consensus, Aspasius should be regarded as a Peripatetic, or even as an “orthodox Peripatetic” (Barnes’ phrase). It is true that Aspasius’ commentary is generally in tune with Aristotle. It is true that he shows an extensive knowledge of Aristotelian research pertinent for the discussions and that he uses Aristotelian concepts, principles, and doctrines with ease as if they were his own, thus denoting an old assimilation of those materials and a long accommodation to them. In a word, it is true that Aspasius is an Aristotelian. He is, however, as I will try to show in this paper, an Aristotelian strongly influenced by Stoicism. I will do so by selecting those points from Aspasius’ commentary on book I of the
Analytical issues of serum free light chain assays and the relative performance of polyclonal and monoclonal based reagents
Authors: Carr-Smith Hugh D. , Jenner Ellen L. , Evans Josie A.R. , Harding Stephen J. 
Published: March 2016

AbstractSerum free light chain (FLC) assays have been incorporated into routine clinical practice and their use is recommended in international guidelines for the management of monoclonal gammopathies. Given that FLCs are not simple analytes, laboratories should be aware of potential analytical issues when using FLC assays, including antigen excess, lot-to-lot variation and non-linearity. Whilst manufacturers of monoclonal antibody-based assays claim that they overcome such issues, the evidence available to date does not support this. Here we review and compare the technical performance of both polyclonal and monoclonal antibody-based assays. The evidence suggests that the Freelite assay, based on polyclonal antisera, gives a broader recognition of monoclonal FLCs than the N Latex assay, based on monoclonal antisera, and despite being cited as a technical concern, we show that lot-to-lot variation of the Freelite assay is good. Both non-linearity and antigen excess are characteristic of FLC analysis and laboratories should be aware of these phenomena regardless of the assay system they use. Comparisons of the absolute values of sFLCs determined using monoclonal and polyclonal antibody-based assays show poor quantitative agreement and, because current guidelines have been established using the polyclonal antibody-based Freelite assay, it should not be assumed that assays utilizing monoclonal antibodies will give compliance with these guidelines.
Prenatal diagnosis and management of Van der Woude syndrome
Authors: García Karla Ferreres , Berenguer Beatriz , Quintana Luis Ortiz , De Tomás Vicente Elena , Pérez-Pacheco Ricardo Fernández , De León Luis Juan Antonio 
Published: March 2016

Abstract
We report the postnatal diagnosis of Van der Woude syndrome (VWS) in a foetus found to have an isolated right cleft lip and palate by ultrasound examination. After prenatal genetic counselling, the parents declined further evaluation by amniocentesis. At delivery, the infant was also found to have labial pits in the lower lip in addition to the cleft lip and palate identified by ultrasound consistent with VWS. Although VWS is rare, its autosomal dominant inheritance and variable penetrance should prompt additional modalities to more thoroughly evaluate the extent of other organ system and more extensive craniofacial anomalies.
Acardius-myelacephalus: management of a misdiagnosed case of twin reversed arterial perfusion sequence with tense polyhydramnios
Authors: Ibraheem Awowole , Marcel Ukah , Temitope Okunola , Boluwatife Idowu 
Published: March 2016

Abstract

Background: Twin reversed arterial perfusion (TRAP) sequence is the most severe form of twin to twin transfusion syndrome. Survival of the pump twin is threatened by extreme prematurity from polyhydramnios and cardiac failure, necessitating interventions. Rarely, interventions are indicated as a result of maternal life-threatening complications. The management of an acardiac-myelacephalus variant of TRAP sequence, complicated by severe maternal respiratory distress from tense polyhydramnios is presented in this report.

Case presentation: A 29-year-old G3P2, Alive2 was referred to the Perinatal Unit on account of ultrasound diagnosed twin gestation with demise of one twin at an estimated gestational age (EGA) of 29 weeks. She was in severe respiratory distress with central cyanosis, and grossly distended abdomen. Ultrasonography revealed twin gestation with cardiac activity in only one twin and polyhydramnios. The second twin had no recognizable human body structure and retrograde umbilical arterial flow. TRAP sequence with tense polyhydramnios was diagnosed. The respiratory distress was relieved with serial reductive amniocentesis, and she was managed conservatively until an EGA of 34 weeks, when she delivered a live twin that weighed 2.05 kg, and an amorphous twin with a rudimentary limb that weighed 1.82 kg following spontaneous rupture of membranes. Monochorionic placentation was confirmed at delivery. The pump twin was discharged in a satisfactory state after a period of observation.

Conclusion: TRAP sequence may be easily misdiagnosed due to its rarity, with adverse consequences. Accurate diagnosis of the condition, and the provision of basic facilities for in utero interventions when indicated are necessary for fetal salvage.
The Choosing Wisely campaign – don’t throw the baby out with the bathwater
Authors: Plebani Mario , Chiozza Maria Laura , Scibetta Domenico 
Published: March 2016

Abstract
The goal of the Choosing Wisely campaign launched in 2009 by the American Board of Internal Medicine (ABIM) Foundation is to promote dialog on avoiding wasteful or unnecessary medical tests, treatments and procedures. Originating in 2009, the Choosing Wisely initiative involved three primary care specialties in a project aiming to develop “Top Five” lists, which were to be “specialty-specific enumerations of achievable practice changes to improve patient health through better treatment choices, reduced risks and reduced costs. The initiative soon became global, many specialty societies outside the US joining. Some time later, however, data collected demonstrated that a reduction had been achieved only for a few low-value tests and procedures, thus highlighting the need for a more evidence-based approach for identifying low-value practices and for evaluating the efficacy of this initiative over time.
Optimization of a forest harvesting set based on the Queueing Theory: Case study from Karelia
Authors: Shegelman Ilya , Budnik Pavel , Morozov Evsey 
Published: March 2016

Abstract
The modern technological process of timber harvesting is a complex system both technically and organizationally. Nowadays, the study of such systems and improvement of their efficiency is impossible without the use of mathematical modeling methods. The paper presents the methodology for the optimization of logging operations based on the queueing theory. We show the adapted queueing model, which characterizes the process of logging with the use of a harvesting set consisting of harvesters and forwarders. We also present the experimental verification of the designated model that confirmed mode’s adequacy. The analysis of the effectiveness of the investigated harvesting set was conducted and the recommendations for its optimization were drawn. The research was conducted in the Pryazhinsky District in the Republic of Karelia. We showed that significant improvement of operational efficiency of the investigated harvesting set in the study area cannot be done by adjusting separate machine operations (i.e. by reducing the time of operations execution and their steadiness). However, a change in the number of machines allowed significant improvement in the operational efficiency. The most optimal harvesting set design for the experimental area consisted of two harvesters and two forwarders.