bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Value Orientation Moderates the Effects of Intuition versus Reflection on Responses to Unfair Ultimatum Offers
Authors: Bieleke Maik , Gollwitzer Peter M. , Oettingen Gabriele , Fischbacher Urs 
Published: August 2016

AbstractWe investigated whether social value orientation (SVO) moderates the effects of intuitive versus reflective information processing on responses to unfair offers. We measured SVO one week prior to an ultimatum game experiment in which participants had to accept or reject a series of 10 ultimatum offers including very low (unfair) ones. Before making these decisions, participants mentally contrasted their individual goals with the obstacle of pondering at length or acting in a hasty way; then they made the plan to adopt an intuitive or a reflective mode of processing (intuitive and reflective condition, respectively), or made no such plans (control condition). Participants with rather high (prosocial) SVO scores were more likely to accept unfair offers in the reflective than the intuitive condition. This effect also evinced for a subset of selfish individuals; however, the majority with rather low (selfish) scores made similar decisions in both conditions. This pattern of results suggests that SVO moderates the effects of intuitive versus reflective modes of processing on responses to low ultimatum offers. Copyright © 2016 John Wiley & Sons, Ltd.
Nanoparticle‐Imprinted Matrices as Sensing Layers for Size‐Selective Recognition of Silver Nanoparticles
Authors: Witt Julia , Mandler Daniel , Wittstock Gunther 
Published: August 2016

AbstractThis study extends the concept of nanoparticle‐imprinted matrices (NAIMs) to systems in which template nanoparticles (NPs) are immobilized on a conducting surface and a polymer matrix is built around them before the release of the template NPs. Specifically, citrate‐stabilized AuNPs, 40 nm in diameter, were bound to a 3‐aminopropyltriethoxysilane (APTES)‐modified indium tin oxide (ITO) electrode at pH 5. Subsequently, a polymer matrix was generated by electropolymerization of a self‐inhibiting poly(phenol) (PPh) layer. The template AuNPs were removed either by electro‐oxidation of the Au core during linear sweep voltammetry (LSV) in Cl−‐containing aqueous solution or by chemical oxidation in aqueous KCN solution. After template removal, remaining nanocavities were found to be size‐selective in the competitive reuptake of analyte NPs, as demonstrated by the preference for citrate‐stabilized silver nanoparticles (AgNPs) with 20 nm diameter over AuNPs with 50 nm diameter. The remaining nanocavities and their size‐recognition ability were examined by scanning electron microscopy and LSV. Complementing studies by X‐ray photoelectron spectroscopy and scanning force microscopy corroborated the template embedding, template release, and analyte NP uptake.
ChemInform Abstract: Polar Noncentrosymmetric ZnMoSb2O7 and Nonpolar Centrosymmetric CdMoSb4O10: d10 Transition Metal Size Effect Influencing the Stoichiometry and the Centricity.
Authors: Jo Hongil , Ok Kang Min 
Published: August 2016

AbstractPolycrystalline ZnMoSb2O7 (I) and CdMoSb4O10 (II) are prepared from stoichiometric amounts of ZnO or CdO, MoO3, and Sb2O3 (evacuated quartz tubes, 500 °C, 1 d).
ChemInform Abstract: Symmetry Switching of Negative Thermal Expansion by Chemical Control.
Authors: Senn Mark S. , Murray Claire A. , Luo Xuan , Wang Lihai , Huang Fei‐Ting , Cheong Sang‐Wook , Bombardi Alessandro , Ablitt Chris , Mostofi Arash A. , Bristowe Nicholas C. 
Published: August 2016

AbstractPolycrystalline samples of the layered perovskite Ca3‐xSrxMn2O7 (x = 0—2) are prepared by firing stoichiometric amounts of CaCO3, SrCO3, and MnO2 in an O2 stream (1340—1650 °C).
ChemInform Abstract: A Novel Material of HfScMo2VO12 with Negative Thermal Expansion and Intense White‐Light Emission.
Authors: Cheng Yongguang , Liang Yuan , Ge Xianghong , Liu Xiansheng , Yuan Baohe , Guo Juan , Chao Mingju , Liang Erjun 
Published: August 2016

AbstractHfScMo2VO12 is prepared by solid state reaction of stoichiometric amounts of HfO2, Sc2O3, V2O5, and MoO3 (air, 973 K, 5 h).
ChemInform Abstract: Bromine‐Rich Zinc Bromides: Zn6Br12(18‐crown‐6)2x (Br2)5, Zn4Br8(18‐crown‐6)2x (Br2)3, and Zn6Br12(18‐crown‐6)2x (Br2)2.
Authors: Hausmann David , Feldmann Claus 
Published: August 2016

AbstractThe title compounds are prepared by the reaction of 0.63 equiv.
ChemInform Abstract: Open‐Framework Oxysulfide Based on the Supertetrahedral [In4Sn16O10S34]12— Cluster and Efficient Sequestration of Heavy Metals.
Authors: Zhang Xian‐Ming , Sarma Debajit , Wu Ya‐Qin , Wang Li , Ning Zhi‐Xue , Zhang Fu‐Qiang , Kanatzidis Mercouri G. 
Published: August 2016

Abstract[H3O]3[Heta]4.2 [H2dpp]0.3 [In4Sn16O10S32] ·33H2O is prepared by heating a 10:3:3:3 molar mixture of S, SnCl2·2H2O, In(NO3)3, and 1,3‐di(4‐pyridyl)propane (dpp) in ethanolamine (eta) (autoclave, 160 °C, 7 d; 25% yield).
ChemInform Abstract: Synthesis, Structural and Optical Characterization of APbX3 (A: Methylammonium, Dimethylammonium, Trimethylammonium; X: I, Br, Cl) Hybrid Organic‐Inorganic Materials.
Authors: Mancini Alessandro , Quadrelli Paolo , Amoroso Giuseppe , Milanese Chiara , Boiocchi Massimo , Sironi Angelo , Patrini Maddalena , Guizzetti Giorgio , Malavasi Lorenzo 
Published: August 2016

AbstractAPbX3 (A: MeNH3+, Me2NH2+, Me3NH+; X: I, Br) hybrid organic‐inorganic compounds are prepared by dissolving appropriate amounts of Pb(O‐Ac)2 in excess HX (100 °C) followed by the addition of the respective amine (25—40% in H2O) in stoichiometric quantities and subsequent cooling to 46 °C at a rate of 1 °C/min.
ChemInform Abstract: Synthesis, Structure, and Electronic Structure Calculation of a New Centrosymmetric Borate Pb2O[BO2(OH)] Based on Anion‐Centered OPb4 Tetrahedra.
Authors: Sun Feng , Wang Li , Stoumpos Constantinos C. 
Published: August 2016

AbstractThe new title compound is prepared by hydrothermal reaction of a 1:2:5 molar mixture of Pb(NO3)2, SrCO3, and H3BO3 in 1 M KOH (autoclave, 180 °C, 1 d, 40% yield).
ChemInform Abstract: Synthesis, Characterization and Catalytic Activity of New Bis(N‐2,6‐diphenylphenol‐R‐salicylaldiminato)Pd(II) Complexes in Suzuki—Miyaura and CO2 Fixation Reactions.
Authors: Oncel Nurdal , Kasumov Veli T. , Sahin Ertan , Ulusoy Mahmut 
Published: August 2016

AbstractNovel Pd(II)‐salicylaldimine complexes are synthesized and their ability to catalyze the Suzuki—Miyaura coupling of aryl bromides as well as the formation of cyclic carbonates from epoxides and CO2 is evaluated.
ChemInform Abstract: Evolution of the Reaction Mechanism During the MTH Induction Period over the 2‐Dimensional FER Zeolite.
Authors: Qi Liang , Li Jinzhe , Xu Lei , Liu Zhongmin 
Published: August 2016

AbstractIt is found that a shorter methanol‐to‐hydrocarbon (MTH) induction period can be reached by additionally supplying toluene or pre‐cooking the catalyst.
ChemInform Abstract: Development of Polymer‐Supported Chiral Aminoalcohols Derived from Biomass and Their Application to Asymmetric Alkylation.
Authors: Botta Maria C. , Biava Hernan D. , Spanevello Rolando A. , Mata Ernesto G. , Suarez Alejandra G. 
Published: August 2016

AbstractNovel polymer‐supported chiral aminoalcohols are tested as chiral ligands for the asymmetric diethylzinc addition to aromatic aldehydes.
ChemInform Abstract: Ligand‐Controlled Product Selectivity in Palladium‐Catalyzed Domino post‐Ugi Construction of (Spiro)polyheterocycles.
Authors: Li Zhenghua , Sharma Nandini , Sharma Upendra K. , Jacobs Jeroen , Van Meervelt Luc , Van der Eycken Erik V. 
Published: August 2016

AbstractThe title compounds are prepared by domino cyclization of Ugi‐adducts using XantPhos or BINAP as ligand.
ChemInform Abstract: A Unified Approach to Pyrrole‐Embedded Aza‐Heterocyclic Scaffolds Based on the RCM/Isomerization/Cyclization Cascade Catalyzed by a Ru/B‐H Binary Catalyst System.
Authors: Inamdar Suleman M. , Chakrabarty Indradweep , Patil Nitin T. 
Published: August 2016

AbstractThe title compounds are prepared by a cascade reaction sequence of (pyrrolylphenyl)allylacrylamides using Hoveyda‐Grubbs II/BINOL hydrogen phosphate as catalyst.
ChemInform Abstract: Dearomatization of Electron‐Deficient Nitrogen Heterocycles via Cobalt‐Catalyzed Asymmetric Cyclopropanation.
Authors: Joshi‐Pangu Amruta , Cohen Ryan D. , Tudge Matthew T. , Chen Yonggang 
Published: August 2016

AbstractVarious fused nitrogen containing heteroarenes, including electron‐deficient ones, are cyclopropanated in a highly diastereoselective and enantioselective manner.
ChemInform Abstract: Reagents for Storage and Regeneration of Nonstabilized Azomethine Ylides: Spiroanthraceneoxazolidines.
Authors: Buev Evgeny M. , Moshkin Vladimir S. , Sosnovskikh Vyacheslav Y. 
Published: August 2016

AbstractThe unusual properties of spiroanthraceneoxazolidines (I) derived from easily accessible anthraquinone, N‐substituted glycine, and formaldehyde are reported.
ChemInform Abstract: Bioinspired Aerobic Oxidation of Alcohols with a Bifunctional Ligand Based on Bipyridine and TEMPO.
Authors: Wang Lianyue , Bie Zhixing , Shang Sensen , Lv Ying , Li Guosong , Niu Jingyang , Gao Shuang 
Published: August 2016

AbstractAldehydes and ketones are prepared in good to excellent yields by oxidation of various alcohols including primary benzylic, allylic, alkynyl, aliphatic alcohols, and secondary benzylic alcohols.
ChemInform Abstract: TCDA: Practical Synthesis and Application in the Trifluoromethylation of Arenes and Heteroarenes.
Authors: Wang Jian , Zhang Xiaomin , Wan Zehong , Ren Feng 
Published: August 2016

AbstractAn improved synthesis of trimethylsilyl chlorodifluoroacetate (TCDA) is developed and the reagent is successfully used to introduce CF3‐groups into aryl and hetaryl iodides.
ChemInform Abstract: An Efficient Synthesis of N‐Nitrosamines under Solvent, Metal and Acid Free Conditions Using tert‐Butyl Nitrite.
Authors: Chaudhary Priyanka , Gupta Surabhi , Muniyappan Nalluchamy , Sabiah Shahulhameed , Kandasamy Jeyakumar 
Published: August 2016

AbstractA series of N‐nitrosamines is synthesized from the corresponding secondary amines using tert‐butyl nitrite under solvent‐free conditions.
ChemInform Abstract: Ni(bpy)(cod): A Convenient Entryway into the Efficient Hydroboration of Ketones, Aldehydes, and Imines.
Authors: King Amanda E. , Stieber S. Chantal E. , Henson Neil J. , Kozimor Stosh A. , Scott Brian L. , Smythe Nathan C. , Sutton Andrew D. , Gordon John C. 
Published: August 2016

AbstractThe title reaction is investigated under NMR conditions resulting in the formation of products from the hydroboration of the C=O and C=N bond.
ChemInform Abstract: Synthesis of β‐Substituted Cyclic Enones via Phosphonium Salt‐Activated, Palladium‐Catalyzed Cross‐Coupling of Cyclic 1,3‐Diones.
Authors: Yang Shyh‐Ming , Kuo Gee‐Hong , Gaul Michael D. , Murray William V. 
Published: August 2016

AbstractActivation of cyclic 1,3‐diones with PyBroP generates phosphonium salt intermediates which readily undergo Pd‐catalyzed Suzuki—Miyaura coupling with boronic acids and pinacol esters as well as Pd/Cu‐catalyzed Sonogashira coupling with terminal alkynes.
ChemInform Abstract: Carbohydrate‐Catalyzed Enantioselective Alkene Diboration: Enhanced Reactivity of 1,2‐Bonded Diboron Complexes.
Authors: Fang Lichao , Yan Lu , Haeffner Fredrik , Morken James P. 
Published: August 2016

AbstractThe reaction is proposed to involve intermediary 1,2‐bonded diboron‐complexes ((dioxadiborinino)dioxadiborinine‐type).
ChemInform Abstract: Ring Opening of 6‐Azabicyclo[3.1.0]hex‐3‐en‐2‐ols in Water under Mild Conditions.
Authors: Vale Joao R. , Siopa Filipa , Branco Paula S. , Afonso Carlos A. M. 
Published: August 2016

AbstractThe title process, investigated for the preparation of aminocyclopentitol units, becomes possible in the presence of nitrogen‐ and sulfur‐containing nucleophiles under physiological conditions.
ChemInform Abstract: Phosphine‐Free Chiral Iridium Catalysts for Asymmetric Catalytic Hydrogenation of Simple Ketones.
Authors: Kumar Prashant , Irrgang Torsten , Kostakis George E. , Kempe Rhett 
Published: August 2016

AbstractNovel efficient and easily accessible pyridylalkylamine mononuclear iridium complexes are synthesized and utilized in the asymmetric hydrogenation of various ketones affording the corresponding alcohols.
ChemInform Abstract: Construction of Substituted Benzenes via Pd‐Catalyzed Cross‐Coupling/Cyclization Reaction of Vinyl Halides and Terminal Alkynes.
Authors: Xie Meihua , Wang Shengke , Wang Jun , Fang Kuang , Liu Changqing , Zha Chao , Jia Jing 
Published: August 2016

AbstractThe one‐pot tandem Sonogashira coupling/cyclization/aromatization reaction of β‐halo vinyl sulfones or ketones with terminal aryl or alkyl alkynes provides polysubstituted, functionalized benzenes endowed with a versatile sulfonyl or acyl group in high yields.
ChemInform Abstract: Two Phenyls Are Better Than One or Three: Synthesis and Application of Terminal Olefin‐Oxazoline (TOlefOx) Ligands.
Authors: Zhao Yi‐Shuang , Liu Jian‐Kang , He Zhi‐Tao , Tao Jing‐Chao , Tian Ping , Lin Guo‐Qiang 
Published: August 2016

AbstractA novel terminal olefin‐oxazoline ligand containing two diphenylmethyl groups is used in the highly enantioselective rhodium‐catalyzed conjugate addition of aryl boronic acids to enones.
ChemInform Abstract: Alkyne [2 + 2 + 2]‐Cyclotrimerization Approach for Synthesis of 6,7‐Cyclopropylallocolchicinoids.
Authors: More Atul A. , Ramana Chepuri V. 
Published: August 2016

AbstractThe title reaction is efficiently used for the synthesis of cyclopropylallocolchicinoid (IIIa) and a range of C9, C10 and/or C11 substituted analogues.
ChemInform Abstract: Synthesis of 3‐Fluoroalkenyl‐3‐trifluoromethyl‐2‐oxindoles by the Reaction of Indoline‐2,3‐diones with Difluoromethylene Phosphabetaine.
Authors: Liu Yingle , Zhang Ke , Huang Yangen , Pan Shen , Liu Xiao‐Qiang , Yang Yi , Jiang Yan , Xu Xiu‐Hua 
Published: August 2016

AbstractThe unprecedented reaction of indoline‐2,3‐diones (I) with difluoromethylene phosphabetaine (II) gives rise to novel 3‐fluoroalkenyl‐3‐trifluoromethyl‐2‐oxindoles (III), which are converted into derivatives (V) and (VI).
ChemInform Abstract: Synthesis of Functionalized 2,3‐Dihydropyrroles by Oxidative Radical Cyclization of N‐Sulfonyl β‐Enamino Esters with Alkenes.
Authors: Yoshida Masahiro , Kobayashi Asuka , Nakayama Atsushi , Namba Kosuke 
Published: August 2016

AbstractThe efficient protocol tolerates various alkenes, such as 1‐substituted and 1,1‐disubstituted styrene derivatives and cyclic alkenes.
ChemInform Abstract: Superbase/Saccharide: An Ecologically Benign Catalyst for Efficient Fixation of CO2 into Cyclic Carbonates.
Authors: Cheng Weiguo , Xu Fei , Sun Jian , Dong Kun , Ma Congkai , Zhang Suojiang 
Published: August 2016

AbstractCyclic carbonates (III) are simply and efficiently synthesized by a cycloaddition reaction of epoxides (I) with CO2 (II).
ChemInform Abstract: Copper(II)‐Catalyzed C—S Cross‐Coupling with Thiazolidine‐2‐thiones and Boronic Acids: Synthesis of Azole Sulfides.
Authors: Shanmugapriya Jayabalan , Rajaguru Kandasamy , Muthusubramanian Shanmugam , Bhuvanesh Nattamai 
Published: August 2016

AbstractA library of pharmaceutically interesting azole sulfides is readily available under non‐basic, mild conditions without the need of an ancillary ligand.
ChemInform Abstract: Copper Immobilized Ferromagnetic Nanoparticle Triazine Dendrimer (FMNP@TD—Cu(II))‐Catalyzed Regioselective Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles.
Authors: Bahrami Kiumars , Sheikh Arabi Mehdi 
Published: August 2016

AbstractThe novel catalyst is environmentally safe and economical.
ChemInform Abstract: Palladium‐Catalyzed Amination of C‐5 Bromoimidazo[2,1‐b][1,3,4]thiadiazoles.
Authors: Copin Chloe , Buron Frederic , Routier Sylvain 
Published: August 2016

AbstractA library of C‐5 brominated substrates is prepared and subjected to amination under conditions A).
ChemInform Abstract: Design, Synthesis and Cytotoxicity of Pyrano[4,3‐b]indol‐1(5H)‐ones: A Hybrid Pharmacophore Approach via Gold Catalyzed Cyclization.
Authors: Praveen Chandrasekar , Ananth D. Babu 
Published: August 2016

AbstractA gold(III)‐catalyzed 6‐endo‐dig cycloisomerization of 2‐alkynyl‐indole‐3‐carboxylic acids is reported to obtain the title compounds (II) in good yields.
ChemInform Abstract: Base‐Catalyzed Asymmetric α‐Functionalization of 2‐(Cyanomethyl)azaarene N‐Oxides Leading to Quaternary Stereocenters.
Authors: Izquierdo Joseba , Landa Aitor , Bastida Inaki , Lopez Rosa , Oiarbide Mikel , Palomo Claudio 
Published: August 2016

AbstractA highly enantioselective α‐functionalization of 2‐(cyanomethyl)pyridine N‐oxides and pyrazine N‐oxides via conjugate addition of 4‐hydroxy‐4‐methylpent‐1‐en‐3‐one or α‐amination with di(tert‐butyl) or dibenzyl azodicarboxylate is developed.
ChemInform Abstract: Microwaves and Aqueous Solvents Promote the Reaction of Poorly Nucleophilic Anilines with a Zincke Salt.
Authors: Zeghbib Narimane , Thelliere Paul , Rivard Michael , Martens Thierry 
Published: August 2016

AbstractThe reaction tolerates a wide range of functional groups and delivers the arylpyridinium chloride products in generally high yields.
ChemInform Abstract: Metal Free Carboamination of Internal Alkynes — An Easy Access to Polysubstituted Quinolines.
Authors: Stopka T. , Niggemann M. 
Published: August 2016

AbstractThe cyclization of unactivated alkynes with ortho‐azidobenzyl alcohols in the presence of a synergistic Broensted acid catalyst system affords various polysubstituted quinolines via a highly reactive vinyl cation in a C—C bond formation followed by a Schmidt reaction.
ChemInform Abstract: Synthesis of New Quinolinones from 3‐Nitropyranoquinolinones.
Authors: Morsy Jehan M. , Hassanin Hany M. , Ismail Mostafa M. , Abd‐Alrazk Marwa M. A. 
Published: August 2016

AbstractThe alkaline hydrolysis of 3‐nitropyranoquinolinones (I) gives five different products depending on the refluxing time, which are formed by progressive degradation of the nitropyrano ring.
ChemInform Abstract: Generation of Tertiary and Quaternary Stereocenters Through Palladium‐Catalyzed Intramolecular Heck‐Type Reactions for the Stereocontrolled Synthesis of Pyrrolo[1,2‐b]isoquinolines.
Authors: Azcargorta Ane Rebolledo , Coya Estibaliz , Barbolla Iratxe , Lete Esther , Sotomayor Nuria 
Published: August 2016

AbstractDifferent 2‐alkenyl‐substituted pyrroles and pyrrolidines are investigated as cyclization precursors: Pd sources, ligands (chiral and achiral), bases and solvents are tested to produce an optimal result concerning the required stereocenters.
ChemInform Abstract: One‐Pot Synthesis and Antifungal Activity Against Plant Pathogens of Quinazolinone Derivatives Containing an Amide Moiety.
Authors: Zhang Jin , Liu Jia , Ma Yangmin , Ren Decheng , Cheng Pei , Zhao Jiawen , Zhang Fan , Yao Yuan 
Published: August 2016

AbstractA facile one‐pot, three‐component synthesis of the title quinazolinone derivatives (IV) (39 examples) is developed.
ChemInform Abstract: One‐Pot, Regiospecific Assembly of (E)‐Benzamidines from δ‐ and γ‐Amino Acids via an Intramolecular Aminoquinazolinone Rearrangement.
Authors: Schroeder Chad E. , Neuenswander Sarah A. , Yao Tuanli , Aube Jeffrey , Golden Jennifer E. 
Published: August 2016

AbstractThe utility of the effective method is demonstrated by its incorporation in the synthesis of various novel benzamidine structures of pharmaceutical interest.
ChemInform Abstract: Efficient Three‐Step Synthesis of Benzo[e]imidazo[1,2‐c][1,2,3]triazines.
Authors: Pilali Hedieh , Kamazani Shirin Faraji , Moradi Shahram , Moghimi Setareh , Mahdavi Mohammad , Firoozpour Loghman , Shafiee Abbas , Foroumadi Alireza 
Published: August 2016

AbstractTitle compounds (II) are efficiently synthesized through intermediate diazonium formation followed by intramolecular N—N bond formation using a simple and metal‐free strategy.
ChemInform Abstract: Borylation of Olefin C—H Bond via Aryl to Vinyl Palladium 1,4‐Migration.
Authors: Hu Tian‐Jiao , Zhang Ge , Chen Ya‐Heng , Feng Chen‐Guo , Lin Guo‐Qiang 
Published: August 2016

AbstractThe first examples for an aryl to vinyl palladium 1,4‐migration are presented.
ChemInform Abstract: Selective Deprotection of Trityl Group on Carbohydrate by Microflow Reaction Inhibiting Migration of Acetyl Group.
Authors: Miyagawa Atsushi , Tomita Ryusuke , Kurimoto Kenta , Yamamura Hatsuo 
Published: August 2016

AbstractTrityl groups at the 6‐position of sugars like (I) are efficiently deprotected under optimized microflow reaction conditions that inhibit migration of neighboring acetyl groups.
ChemInform Abstract: Paecilonic Acids A and B, Bicyclic Fatty Acids from the Jellyfish‐Derived Fungus Paecilomyces variotii J08NF‐1.
Authors: Wang Haibo , Hong Jongki , Yin Jun , Liu Juan , Liu Yonghong , Choi Jae Sue , Jung Jee H. 
Published: August 2016

Abstractisolation and structure elucidation
ChemInform Abstract: Broadband Yellowish‐Green Emitting Ba4Gd3Na3 (PO4)6F2:Eu2+ Phosphor: Structure Refinement, Energy Transfer, and Thermal Stability.
Authors: Fu Xiaopeng , Lue Wei , Jiao Mengmeng , You Hongpeng 
Published: August 2016

AbstractA series of Ba4‐xGd3Na3 (PO4)6F2:xEu2+ phosphors are prepared by sintering a stoichiometric mixture of raw materials with an excess of BaF2 under a H2(10%)/N2 reducing atmosphere (1075 °C, 6 h).
Race and mortality risk after radiation therapy in men treated with or without androgen‐suppression therapy for favorable‐risk prostate cancer
Authors: Kovtun Konstantin A. , Chen Ming‐Hui , Braccioforte Michelle H. , Moran Brian J. , D'Amico Anthony V. 
Published: August 2016

BACKGROUNDAfrican American (AA) men are more likely than non‐AA men to have a comorbid illness that could interact with androgen‐deprivation therapy (ADT) and shorten survival. This study assessed the impact that race had on the risk of all‐cause mortality (ACM) and other‐cause mortality (OCM) among men definitively treated for favorable‐risk prostate cancer (PC).METHODSBetween 1997 and 2013, 7252 men with low‐risk or favorable intermediate‐risk PC were treated with brachytherapy with neoadjuvant ADT (n = 1501) or without neoadjuvant ADT (n = 5751) for a 4‐month median duration. Cox and Fine‐Gray multivariate regressions were used to analyze whether the risk of ACM and OCM increased among AA men versus non‐AA men receiving ADT; adjustments were made for the age at brachytherapy, year of brachytherapy, cardiometabolic comorbidity status, risk group, and ADT treatment propensity score.RESULTSAfter a median follow‐up of 8.04 years, 869 men (12.0%) died: 48 (5.52%) of PC and 821 (94.48%) of other causes. There was a significant association between AA race and an increased risk of both ACM (adjusted hazard ratio [AHR], 1.77; 95% confidence interval [CI], 1.06‐2.94; P = .028) and OCM (AHR, 1.86; 95% CI, 1.08‐3.19; P = .024) among AA men versus non‐AA men who received ADT but not among those who did not receive ADT (AHR for ACM, 1.33; 95% CI, 0.93‐1.91; P = .12; AHR for OCM, 1.39; 95% CI, 0.96‐2.02; P = .08).CONCLUSIONSADT use may shorten survival in AA men with favorable‐risk PC; therefore, its reservation for the treatment of higher risk PC, for which level 1 evidence supports its use, should be considered. Cancer 2016;122:3608‐14. © 2016 American Cancer Society.