bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representing Canadian justice: legal iconography and symbolism at the Supreme Court of Canada
Authors: DesBaillets David 
Published: May 2017

Abstract
This paper examines the intersection between a distinctly Canadian legal culture and the legal architecture, symbolism and iconography of its Supreme Court building in Ottawa. I begin from the premise originally put forward in Resnik and Curtis’s study of legal architecture. I proceed with an analysis of the Court’s history, aesthetic and decorative elements, geography and design, artistic and legal vision of the architect, and the social, political and historical contexts in which it was created, as well as key legal and constitutional concepts embodied by the Court’s legal architecture and a comparative analysis with another courthouse in Montreal (the Édifice Ernest Cormier). The paper demonstrates that the challenges of creating a courthouse that reflects the legal traditions and evolving social norms as well as the aspirations of a dynamic, democratic and pluralistic society are almost impossible. It remains a problematic question whether the image of justice that the Court evokes to the observer is the most ‘eloquent three dimensional representation of the role the Supreme Court has assumed in the life of the nation’ (Canada and Supreme Court, 2000, p. 207).
A naturalistic longitudinal study of the order of service provision with respect to cocaine use and outcomes in an urban homeless sample
Authors: Ayvaci E. R. , Obiri O. , Pollio D. , North C. S. 
Published: May 2017

Aims.Little is known about outcomes of drug abuse related to attainment of stable housing. This study examined outcomes of cocaine use and service provision in an urban homeless sample.Methods.Two-year longitudinal study of systematically selected homeless individuals (N = 255) in St. Louis, Missouri from 1999 to 2001. The sample was interviewed three times annually using a structured diagnostic interview. Urine drug testing was conducted at every interview, and service utilisation data were obtained from the structured interviews and the agency-provided service use data.Results.Cocaine use disorder and cocaine use proved to be distinct concepts because they predicted different outcomes across time. Cocaine use predicted subsequent poor housing outcomes, but stable housing had no apparent effect on subsequent use of cocaine. Service use predicted neither subsequent reduced cocaine use nor attainment of stable housing. Services used were appropriate to type of mental health need, but cocaine use may have reduced successful utilisation of appropriate psychiatric services.Conclusion.These findings reinforce the concept that homelessness represents a complex phenomenon and consequently, service systems need to address multiple problems. Service approaches are needed that simultaneously address the complex needs of homeless individuals.
Spanish Adaptation of the Morningness-Eveningness-Stability-Scale improved (MESSi)
Authors: Díaz-Morales Juan F. , Randler Christoph 
Published: May 2017

AbstractThe aim of the present study was to conduct the preliminary adaptation of the Morningness-Eveningness-Stability-Scale improved (MESSi) to Spanish population, testing its factor structure and construct validity. Participants were 261 adults (65% women;M= 31.4,SD= 12.01) who filled out measures of Morningness-Eveningness (MESSi and CSM), sleep habits, personality traits, positive and negative affect, and subjective level of alertness during the day. Psychometric results supported a three factorial model with the factors Morning Affect, Eveningness and Distinctness (RMSEA = .072). The factors showed good internal consistence (α = 0.72–0.85). The pattern of correlations between MESSi and the other measures were in the expected direction (low to moderated size effects). Morning Affect was positively predicted by morning chronotype (R2= .64), Eveningness was negatively predicted by age and positively by evening chronotype (R2= .41), and Distinctness was negatively predicted by sex (women reported higher DI than men) and age (R2= .08). This study provides evidence for the factor structure of a new measure of Morningness-Eveningness based on a rigorous psychometric evaluation.
Developmental activities of the complement pathway in migrating neurons
Authors: Gorelik Anna , Sapir Tamar , Haffner-Krausz Rebecca , Olender Tsviya , Woodruff Trent M. , Reiner Orly 
Published: May 2017

AbstractIn recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune molecules in the developing brain has not been well explored. The complement pathway converges to cleave C3. Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice. Molecular mimics of C3 cleavage products rescue the migration defects that have been seen following knockdown of C3 or Masp2. Pharmacological activation of the downstream receptors rescue Masp2 and C3 knockdown as well as C3 knockout. Therefore, we propose that the complement pathway is functionally important in migrating neurons of the developing cortex.
De novo evolved interference competition promotes the spread of biofilm defectors
Authors: Martin Marivic , Dragoš Anna , Hölscher Theresa , Maróti Gergely , Bálint Balázs , Westermann Martin , Kovács Ákos T. 
Published: May 2017

AbstractBiofilms are social entities where bacteria live in tightly packed agglomerations, surrounded by self-secreted exopolymers. Since production of exopolymers is costly and potentially exploitable by non-producers, mechanisms that prevent invasion of non-producing mutants are hypothesized. Here we study long-term dynamics and evolution in Bacillus subtilis biofilm populations consisting of wild-type (WT) matrix producers and mutant non-producers. We show that non-producers initially fail to incorporate into biofilms formed by the WT cells, resulting in 100-fold lower final frequency compared to the WT. However, this is modulated in a long-term scenario, as non-producers evolve the ability to better incorporate into biofilms, thereby slightly decreasing the productivity of the whole population. Detailed molecular analysis reveals that the unexpected shift in the initially stable biofilm is coupled with newly evolved phage-mediated interference competition. Our work therefore demonstrates how collective behaviour can be disrupted as a result of rapid adaptation through mobile genetic elements.
The physiological and molecular response of Aurelia sp.1 under hypoxia
Authors: Wang Guoshan , Zhen Yu , Yu Zhigang , Shi Yan , Zhao Qing , Wang Jianyan , Mi Tiezhu 
Published: May 2017

AbstractFew studies have been published on the mechanisms of hypoxia response and tolerance in jellyfish, especially with respect to the regulatory mechanism at the molecular level. In this study, Aurelia sp.1, which is frequently found in Chinese coastal waters, was cultivated in a hypoxic system to determine the molecular mechanisms underlying its hypoxic response by studying the physiological activity, gene expression and metabolite contents in the prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) oxygen-sensing system. Physiological activity; the expression of PHD, HIF, ALDO (fructose-bisphosphate aldolase), PDK (pyruvate dehydrogenase kinase), and LDH (lactate dehydrogenase) genes; and the lactic acid content in medusae were significantly affected by hypoxia. The up-regulation of ALDO, PDK and LDH, which was directly or indirectly induced by HIF, mediated the transition from aerobic respiration to anaerobic glycolysis in the medusae. In polyps, there was a slight increase in the expression of HIF, PHD and ALDO, no obvious change in that of PDK and a slight decrease in that of LDH throughout the experiment; however, these changes were insufficient to induce the shift. This study provides a scientific basis for elucidating the regulatory mechanism underlying the PHD-HIF oxygen-sensing system in Aurelia sp.1.
Quality of analgesia in physician-operated telemedical prehospital emergency care is comparable to physician-based prehospital care - a retrospective longitudinal study
Authors: Lenssen Niklas , Krockauer Andreas , Beckers Stefan K. , Rossaint Rolf , Hirsch Frederik , Brokmann Jörg C. , Bergrath Sebastian 
Published: May 2017

AbstractAcute pain is a common reason for summoning emergency medical services (EMS). Yet in several countries the law restricts opioid-based analgesia administration to physicians. Telemedical support of paramedics is a novel approach to enable timely treatment under the guidance of a physician. In this retrospective observational study, conducted in the EMS of Aachen, Germany, the analgesic quality and occurrence of adverse events were compared between telemedically-supported paramedics (July-December, 2014) and a historical control group (conventional on-scene EMS physicians; January-March, 2014). Inclusion criteria: pain (initial numerical rating scale (NRS) ≥5) and/or performed analgesia. Telemedically-assisted analgesia was performed in 149 patients; conventional analgesia in 199 control cases. Teleconsultation vs. control: Initial NRS scores were 8.0 ± 1.5 and 8.1 ± 1.7. Complete NRS documentation was carried out in 140/149 vs. 130/199 cases, p < 0.0001. NRS scores were reduced by 4.94 ± 2.01 and 4.84 ± 2.28 (p = 0.5379), leading to mean NRS scores at emergency room arrival of 3.1 ± 1.7 vs. 3.3 ± 1.9 (p = 0.5229). No severe adverse events occurred in either group. Clinically relevant pain reduction was achieved in both groups. Thus, the concept of remote physician-based telemedically-delegated analgesia by paramedics is effective compared to analgesia by on-scene EMS physicians and safe.
Ecotypic differentiation and phenotypic plasticity combine to enhance the invasiveness of the most widespread daisy in Chile, Leontodon saxatilis
Authors: Martín-Forés Irene , Avilés Marta , Acosta-Gallo Belén , Breed Martin F. , del Pozo Alejandro , de Miguel José M. , Sánchez-Jardón Laura , Castro Isabel , Ovalle Carlos , Casado Miguel A. 
Published: May 2017

AbstractDispersal and reproductive traits of successful plant invaders are expected to undergo strong selection during biological invasions. Numerous Asteraceae are invasive and display dimorphic fruits within a single flower head, resulting in differential dispersal pathways - wind-dispersed fruits vs. non-dispersing fruits. We explored ecotypic differentiation and phenotypic plasticity of seed output and fruit dimorphisms in exotic Chilean and native Spanish populations ofLeontodon saxatilissubsp.rothii. We collected flower heads from populations in Spain and Chile along a rainfall gradient. Seeds from all populations were planted in reciprocal transplant trials in Spain and Chile to explore their performance in the native and invasive range. We scored plant biomass, reproductive investment and fruit dimorphism. We observed strong plasticity, where plants grown in the invasive range had much greater biomass, flower head size and seed output, with a higher proportion of wind-dispersed fruits, than those grown in the native range. We also observed a significant ecotype effect, where the exotic populations displayed higher proportions of wind-dispersed fruits than native populations. Together, these patterns reflect a combination of phenotypic plasticity and ecotypic differentiation, indicating thatLeontodon saxatilishas probably increased propagule pressure and dispersal distances in its invasive range to enhance its invasiveness.
Teosinte in Europe – Searching for the Origin of a Novel Weed
Authors: Trtikova Miluse , Lohn Andre , Binimelis Rosa , Chapela Ignacio , Oehen Bernadette , Zemp Niklaus , Widmer Alex , Hilbeck Angelika 
Published: May 2017

AbstractA novel weed has recently emerged, causing serious agronomic damage in one of the most important maize-growing regions of Western Europe, the Northern Provinces of Spain. The weed has morphological similarities to a wild relative of maize and has generally been referred to as teosinte. However, the identity, origin or genetic composition of ‘Spanish teosinte’ was unknown. Here, we present a genome-wide analysis of single-nucleotide polymorphism (SNP) data for Spanish teosinte, sympatric populations of cultivated maize and samples of reference teosinte taxa. Our data are complemented with previously published SNP datasets of cultivated maize and two Mexican teosinte subspecies. Our analyses reveal that Spanish teosinte does not group with any of the currently recognized teosinte taxa. Based on Bayesian clustering analysis and hybridization simulations, we infer that Spanish teosinte is of admixed origin, most likely involvingZea maysssp.mexicanaas one parental taxon, and an unidentified cultivated maize variety as the other. Analyses of plants grown from seeds collected in Spanish maize fields and experimental crosses under controlled conditions reveal that hybridization does occur between Spanish teosinte and cultivated maize in Spain, and that current hybridization is asymmetric, favouring the introgression of Spanish teosinte into cultivated maize, rather than vice versa.
Inferring the evolutionary mechanism of the chloroplast genome size by comparing whole-chloroplast genome sequences in seed plants
Authors: Xiao-Ming Zheng , Junrui Wang , Li Feng , Sha Liu , Hongbo Pang , Lan Qi , Jing Li , Yan Sun , Weihua Qiao , Lifang Zhang , Yunlian Cheng , Qingwen Yang 
Published: May 2017

AbstractThe chloroplast genome originated from photosynthetic organisms and has retained the core genes that mainly encode components of photosynthesis. However, the causes of variations in chloroplast genome size in seed plants have only been thoroughly analyzed within small subsets of spermatophytes. In this study, we conducted the first comparative analysis on a large scale to examine the relationship between sequence characteristics and genome size in 272 seed plants based on cross-species and phylogenetic signal analysis. Our results showed that inverted repeat regions, large or small single copies, intergenic regions, and gene number can be attributed to the variations in chloroplast genome size among closely related species. However, chloroplast gene length underwent evolution affecting chloroplast genome size in seed plants irrespective of whether phylogenetic information was incorporated. Among chloroplast genes, atpA, accD and ycf1 account for 13% of the variation in genome size, and the average Ka/Ks values of homologous pairs of the three genes are larger than 1. The relationship between chloroplast genome size and gene length might be affected by selection during the evolution of spermatophytes. The variation in chloroplast genome size may influence energy generation and ecological strategy in seed plants.
Metabolic Radiomics for Pretreatment 18F-FDG PET/CT to Characterize Locally Advanced Breast Cancer: Histopathologic Characteristics, Response to Neoadjuvant Chemotherapy, and Prognosis
Authors: Ha Seunggyun , Park Sohyun , Bang Ji-In , Kim Eun-Kyu , Lee Ho-Young 
Published: May 2017

AbstractRadiomics has been spotlighted as imaging biomarker for estimation of intratumoral heterogeneity (ITH) which is regarded as the main reason for resistance to tumor treatment. Although a number of studies has shown clinical evidences that separate measurement of metabolic ITH by texture features (TFs) on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has prognostic ability in various tumors, there has been no consensus regarding the best parameter representing ITH. Besides, it is yet uncertain that TFs are useful for estimation of histopathologic markers, prediction of response to neoadjuvant chemotherapy (NAC), or prognostic ability in breast cancer. To depart from the traditional approach, we evaluated the clinical usefulness of integrated metabolic radiomics using unsupervised clustering with 109 TFs measured from pretreatment 18F-FDG PET/CT scans of 73 patients with locally advanced breast cancer (LABC) underwent NAC before surgery. Our study shows that metabolic radiomics patterns of LABC are associated with Ki67 expression, achievement of pathologic complete response after NAC, and risk of recurrence. Integrated metabolic radiomics has potential for clinically relevant pretreatment biomarker with predictive and prognostic ability for personalized management in LABC.
Super-light Cu@Ni nanowires/graphene oxide composites for significantly enhanced microwave absorption performance
Authors: Wang Xiaoxia , Zhang Baoqin , Zhang Wei , Yu Mingxun , Cui Liang , Cao Xueying , Liu Jingquan 
Published: May 2017

AbstractGraphene oxide (GO) was rarely used as microwave absorption (MA) material due to its lower dielectric loss compared with reduced GO (RGO). However, the characteristics of low conductivity, light weight, and large surface area were beneficial to the impedance matching for absorbers already containing highly conductive metal materials. Cu@Ni nanowires are promising MA materials due to the desired dielectric loss from copper and excellent magnetic loss from nickel. However, the high density was an impediment to its further application. Combining Cu@Ni nanowires with GO should be an effective solution to decrease the absorber’s density and improve its MA properties. Herein, we demonstrated that Cu@Ni nanowires/GO composites exhibited enhanced MA capacities compared with Cu@Ni nanowires or GO alone, and the minimum reflection loss reached −42.8 dB at 16.9 GHz with a thickness of 2.1 mm. The enhanced MA performance mainly originated from good impedance matching, as a result of the addition of low conductivity of GO. To confirm this point, the MA performance of Cu@Ni nanowires/RGO was studied, and unsurprisingly, weak MA performance was obtained. Our work provides a new strategy to decrease the density, broaden the frequency band and tune MA performance of composites.
Entropy Evolution in Consensus Networks
Authors: Fu Shuangshuang , Shi Guodong , Petersen Ian R. , James Matthew R. 
Published: May 2017

AbstractWe investigate the evolution of the network entropy for consensus dynamics in classical and quantum networks. We show that in the classical case, the network differential entropy is monotonically non-increasing if the node initial values are continuous random variables. While for quantum consensus dynamics, the network’s von Neumann entropy is in contrast non-decreasing. In light of this inconsistency, we compare several distributed algorithms with random or deterministic coefficients for classical or quantum networks, and show that quantum algorithms with deterministic coefficients are physically related to classical algorithms with random coefficients.
Coupling of equatorial Atlantic surface stratification to glacial shifts in the tropical rainbelt
Authors: Portilho-Ramos R. C. , Chiessi C. M. , Zhang Y. , Mulitza S. , Kucera M. , Siccha M. , Prange M. , Paul A. 
Published: May 2017

AbstractThe modern state of the Atlantic meridional overturning circulation promotes a northerly maximum of tropical rainfall associated with the Intertropical Convergence Zone (ITCZ). For continental regions, abrupt millennial–scale meridional shifts of this rainbelt are well documented, but the behavior of its oceanic counterpart is unclear due the lack of a robust proxy and high temporal resolution records. Here we show that the Atlantic ITCZ leaves a distinct signature in planktonic foraminifera assemblages. We applied this proxy to investigate the history of the Atlantic ITCZ for the last 30,000 years based on two high temporal resolution records from the western Atlantic Ocean. Our reconstruction indicates that the shallowest mixed layer associated with the Atlantic ITCZ unambiguously shifted meridionally in response to changes in the strength of the Atlantic meridional overturning with a southward displacement during Heinrich Stadials 2–1 and the Younger Dryas. We conclude that the Atlantic ITCZ was located at ca. 1°S (ca. 5° to the south of its modern annual mean position) during Heinrich Stadial 1. This supports a previous hypothesis, which postulates a southern hemisphere position of the oceanic ITCZ during climatic states with substantially reduced or absent cross-equatorial oceanic meridional heat transport.
Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
Authors: Miura Takashi , Naruto Masayuki , Toda Katsuaki , Shimomura Taiki , Saito Susumu 
Published: May 2017

AbstractAmides are ubiquitous and abundant in nature and our society, but are very stable and reluctant to salt-free, catalytic chemical transformations. Through the activation of a “sterically confined bipyridine–ruthenium (Ru) framework (molecularly well-designed site to confine adsorbed H2 in)” of a precatalyst, catalytic hydrogenation of formamides through polyamide is achieved under a wide range of reaction conditions. Both C=O bond and C–N bond cleavage of a lactam became also possible using a single precatalyst. That is, catalyst diversity is induced by activation and stepwise multiple hydrogenation of a single precatalyst when the conditions are varied. The versatile catalysts have different structures and different resting states for multifaceted amide hydrogenation, but the common structure produced upon reaction with H2, which catalyzes hydrogenation, seems to be “H–Ru–N–H.”
Emergence of coupling-induced oscillations and broken symmetries in heterogeneously driven nonlinear reaction networks
Authors: Sreenivasan Varsha , Menon Shakti N. , Sinha Sitabhra 
Published: May 2017

AbstractMany natural systems including the brain comprise coupled elements that are stimulated non-uniformly. In this paper we show that heterogeneously driven networks of excitatory-inhibitory units exhibit a diverse range of collective phenomena, including the appearance of spontaneous oscillations upon coupling quiescent elements. On varying the coupling strength a previously unreported transition is seen wherein the symmetries of the synchronization patterns in the stimulated and unstimulated groups undergo mutual exchange. The system also exhibits coexisting chaotic and non-chaotic attractors - a result that may be of interest in connection to earlier reports of varying degrees of chaoticity in the brain.
Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry
Authors: Dodd Jodie M. , Du Plessis Lodewyk E. , Deussen Andrea R. , Grivell Rosalie M. , Yelland Lisa N. , Louise Jennie , Mcphee Andrew J. , Robinson Jeffrey S. , Owens Julie A. 
Published: May 2017

AbstractThe contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analysis of a multicenter randomised trial. Pregnant women with BMI ≥25 kg/m2 received either Lifestyle Advice or Standard Care. Paternal anthropometric measures included height, weight, BMI; waist, hip, calf and mid-upper arm circumferences; biceps and calf skinfold thickness measurements (SFTM); and percentage body fat. Newborn anthropometric outcomes included length; weight; head, arm, abdominal, and chest circumferences; biceps, triceps, subscapular, suprailiac, thigh, and lateral abdominal wall SFTM; and percentage body fat. The effect of an antenatal maternal dietary and lifestyle intervention among women who were overweight or obese on neonatal anthropometric measures, was significantly modified by paternal BMI ≥35.0 kg/m2, with a significantly smaller infant triceps, suprailiac, and thigh SFTM, and percent fat mass, compared with that observed in offspring of lean fathers. Further research is required to determine whether our observed associations are causal, and whether paternal weight loss prior to conception is a potential strategy to reduce the intergenerational effects of obesity.