bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Casper Stent System for carotid artery stenosis
Authors: Mutzenbach Sebastian J , Millesi Katharina , Roesler Cornelia , Broussalis Erasmia , Pikija Slaven , Sellner Johann , Machegger Lukas , Griessenauer Christoph J , Killer-Oberpfalzer Monika 
Published: January 2018

PurposeTo report the results of a retrospective analysis of prospectively collected data evaluating the safety and efficacy of a double layer stent engineered for carotid artery occlusive disease.MethodsBetween January 2014 and February 2017, 138 patients (25.4% women; median age 71 years) underwent Casper stent implantation for carotid artery stenosis. Eligibility criteria included stenosis >70% of vessel diameter (or >50% diameter with ulceration) in symptomatic patients or asymptomatic patients with >80% stenosis at the carotid bifurcation or in the proximal internal carotid artery. For all procedures, a distal embolic protection device was used. The primary endpoint was the rate of 90 day major adverse neurological events, defined as minor stroke, major stroke, or death by independent neurological assessment.ResultsStent deployment was completed successfully in all cases without documented technical failure. There were no adverse neurological events or mortalities within 90 days. One thromboembolic occlusion of a small distal branch of the anterior cerebral artery occurred during the procedure and resolved with systemic recombinant tissue plasminogen activator administration. New ischemic lesions, all clinically silent, were seen in 6.5% of patients on post-procedure cerebral MRI.ConclusionThe Casper carotid stent demonstrated safety and efficacy in the treatment of carotid stenosis, with no technical failures and no adverse neurological events seen throughout the 90 day follow-up period. Its double layer structure seems to combine adequate plaque scaffolding with high vessel adaptability.
Giant pockmark formation from Cretaceous hydrocarbon expulsion in the western Lower Saxony Basin, The Netherlands
Authors: Strozyk Frank , Reuning Lars , Back Stefan , Kukla Peter 
Published: January 2018

Abstract

A field of giant pockmarks was discovered at the base of the Upper Cretaceous Chalk unit in the westernmost Lower Saxony Basin in The Netherlands. 3D seismic and well data show that mostly circular, 300–850 m-wide and 10–50 m-deep, pockmarks formed at the top of the Lower Cretaceous Upper Holland Marl Formation, which overlies oil- and gas-filled Lower Cretaceous sandstone reservoirs in the vicinity of the study area. Based on our interpretations, we present a scenario of early gas generation in Carboniferous coals and a localized migration of the gas from its original subsalt reservoirs through a salt weld in the Zechstein evaporites into the shallow Cretaceous sandstone reservoirs and the fine-grained marl above. Diapiring salt walls thereby limited the gas migration and trapping to a 150 km
2
-sized basin. A sea-level drawdown during Base Chalk formation possibly led to excess pore pressure in the reservoir and the breaching of the seal close to the seafloor, which caused a short-lived expulsion of the gas and pockmark formation. While hydrocarbon generation, migration and trapping are common processes in this region, gas escaping at the seafloor with pockmark generation appears to be a rather rare and complex phenomenon. In general, the presence of pockmarks associated with salt welds may be used to constrain the timing and migration pathway of hydrocarbons from subsalt into shallower reservoir levels. Both features may imply a general reservoir potential for regions where suitable source rocks are missing in the post-salt succession.
Online Adaptation and Energy Minimization for Hardware Recurrent Spiking Neural Networks
Authors: Liu Yu , Jin Yingyezhe , Li Peng 
Published: January 2018

The Liquid State Machine (LSM) is a promising model of recurrent spiking neural networks that provides an appealing brain-inspired computing paradigm for machine-learning applications such as pattern recognition. Moreover, processing information directly on spiking events makes the LSM well suited for cost- and energy-efficient hardware implementation. In this article, we systematically present three techniques for optimizing energy efficiency while maintaining good performance of the proposed LSM neural processors from both an algorithmic and hardware implementation point of view. First, to realize adaptive LSM neural processors, thus boost learning performance, we propose a hardware-friendly Spike-Timing Dependent Plastic (STDP) mechanism for on-chip tuning. Then, the LSM processor incorporates a novel runtime correlation-based neuron gating scheme to minimize the power dissipated by reservoir neurons. Furthermore, an activity-dependent clock gating approach is presented to address the energy inefficiency due to the memory-intensive nature of the proposed neural processors.
Using two different real-world tasks of speech and image recognition to benchmark, we demonstrate that the proposed architecture boosts the average learning performance by up to 2.0% while reducing energy dissipation by up to 29% compared to a baseline LSM with little extra hardware overhead on a Xilinx Virtex-6 FPGA.
Guidelines for experimental models of myocardial ischemia and infarction
Authors: Lindsey Merry L. , Bolli Roberto , Canty John M. , Du Xiao-Jun , Frangogiannis Nikolaos G. , Frantz Stefan , Gourdie Robert G. , Holmes Jeffrey W. , Jones Steven P. , Kloner Robert A. , Lefer David J. , Liao Ronglih , Murphy Elizabeth , Ping Peipei , Przyklenk Karin , Recchia Fabio A. , Schwartz Longacre Lisa , Ripplinger Crystal M. , Van Eyk Jennifer E. , Heusch Gerd 
Published: January 2018

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. With increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results, the goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models.Listen to this article’s corresponding podcast at ajpheart.podbean.com/e/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction/.
Superoxide inhibition restores endothelium-dependent dilatation in aging arteries by enhancing impaired adherens junctions
Authors: Chang Fumin , Flavahan Sheila , Flavahan Nicholas A. 
Published: January 2018

Endothelium-dependent, nitric oxide-mediated dilatation is impaired in aging arteries. The dysfunction reflects increased production of reactive oxygen species (ROS), is reversed by inhibiting superoxide with superoxide dismutase (SOD) mimics, and is assumed to reflect superoxide-mediated inactivation of nitric oxide. However, the dysfunction also reflects Src-dependent degradation and loss of vascular-endothelial (VE)-cadherin from adherens junctions, resulting in a selective impairment in the ability of the junctions to amplify endothelial dilatation. Experiments therefore tested the hypothesis that SOD mimics might restore endothelial dilation in aging arteries by inhibiting Src and protecting endothelial adherens junctions. Tail arteries from young and aging Fisher 344 rats were processed for functional (pressure myograph), biochemical (immunoblot), and morphological (immunofluorescence) analyses. Cell-permeable SOD mimics [manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP) or tempol] did not affect acetylcholine-induced dilatation in young arteries but increased responses and restored normal dilator function in aging arteries. In aging arteries, MnTMPyP decreased Src activity (immunoblots of Tyr416 phosphorylated compared with total Src), increased the intensity and width of VE-cadherin staining at endothelial junctions, and increased VE-cadherin levels in Triton X-100-insoluble lysates, which represents the junctional protein. Because of aging-induced junctional disruption, inhibiting VE-cadherin clustering at adherens junctions with a function-blocking antibody does not affect acetylcholine-induced dilatation in aging arteries. However, the antibody prevented SOD mimics from restoring acetylcholine-induced dilatation in aging arteries. Therefore, SOD mimics improve impaired adherens junctions in aging endothelium, which is essential for SOD mimics to restore endothelium-dependent dilatation in aging arteries. The results suggest an important new pathological role for ROS in aging endothelium, namely, disruption of adherens junctions. NEW & NOTEWORTHY Aging-induced endothelial dysfunction is reversed by SOD mimics. This study demonstrates that they improve impaired adherens junctions in aging endothelium and that their restoration of endothelial dilatation is dependent on increased junctional activity. The results suggest a novel role for oxygen radicals in vascular aging, namely, disruption of adherens junctions.
Genetic Ablation of Rbm38 Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN
Authors: Zhang Jin , Xu Enshun , Ren Cong , Yang Hee Jung , Zhang Yanhong , Sun Wenqiang , Kong Xiangmudong , Zhang Weici , Chen Mingyi , Huang Eric , Chen Xinbin 
Published: January 2018

Abstract
Mutant p53 exerts gain-of-function effects that drive metastatic progression and therapeutic resistance, but the basis for these effects remain obscure. The RNA binding protein RBM38 limits translation of mutant p53 and is often altered in tumors harboring it. Here we show how loss of Rbm38 significantly alters cancer susceptibility in mutant p53 knock-in mice by shortening lifespan, altering tumor incidence, and promoting T-cell lymphomagenesis. Loss of Rbm38 enhanced mutant p53 expression and decreased expression of the tumor suppressor Pten, a key regulator of T-cell development. Furthermore, Rbm38 was required for Pten expression via stabilization of Pten mRNA through an AU-rich element in its 3′UTR. Our results suggest that Rbm38 controls T-cell lymphomagenesis by jointly modulating mutant p53 and Pten, with possible therapeutic implications for treating T-cell malignancies.
Significance: An RNA-binding protein controls T-cell lymphomagenesis by jointly modulating mutant p53 and PTEN, with possible therapeutic implications for treating T-cell malignancies. Cancer Res; 78(6); 1511–21. ©2018 AACR.
Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA
Authors: Goldberg Sarah B. , Narayan Azeet , Kole Adam J. , Decker Roy H. , Teysir Jimmitti , Carriero Nicholas J. , Lee Angela , Nemati Roxanne , Nath Sameer K. , Mane Shrikant M. , Deng Yanhong , Sukumar Nitin , Zelterman Daniel , Boffa Daniel J. , Politi Katerina , Gettinger Scott N. , Wilson Lynn D. , Herbst Roy S. , Patel Abhijit A. 
Published: January 2018

Abstract
Purpose: Decisions to continue or suspend therapy with immune checkpoint inhibitors are commonly guided by tumor dynamics seen on serial imaging. However, immunotherapy responses are uniquely challenging to interpret because tumors often shrink slowly or can appear transiently enlarged due to inflammation. We hypothesized that monitoring tumor cell death in real time by quantifying changes in circulating tumor DNA (ctDNA) levels could enable early assessment of immunotherapy efficacy.
Experimental Design: We compared longitudinal changes in ctDNA levels with changes in radiographic tumor size and with survival outcomes in 28 patients with metastatic non–small cell lung cancer (NSCLC) receiving immune checkpoint inhibitor therapy. CtDNA was quantified by determining the allele fraction of cancer-associated somatic mutations in plasma using a multigene next-generation sequencing assay. We defined a ctDNA response as a &gt;50% decrease in mutant allele fraction from baseline, with a second confirmatory measurement.
Results: Strong agreement was observed between ctDNA response and radiographic response (Cohen's kappa, 0.753). Median time to initial response among patients who achieved responses in both categories was 24.5 days by ctDNA versus 72.5 days by imaging. Time on treatment was significantly longer for ctDNA responders versus nonresponders (median, 205.5 vs. 69 days; P &lt; 0.001). A ctDNA response was associated with superior progression-free survival [hazard ratio (HR), 0.29; 95% CI, 0.09–0.89; P = 0.03], and superior overall survival (HR, 0.17; 95% CI, 0.05–0.62; P = 0.007).
Conclusions: A drop in ctDNA level is an early marker of therapeutic efficacy and predicts prolonged survival in patients treated with immune checkpoint inhibitors for NSCLC. Clin Cancer Res; 24(8); 1872–80. ©2018 AACR.
Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients
Authors: Greif Philipp A. , Hartmann Luise , Vosberg Sebastian , Stief Sophie M. , Mattes Raphael , Hellmann Ines , Metzeler Klaus H. , Herold Tobias , Bamopoulos Stefanos A. , Kerbs Paul , Jurinovic Vindi , Schumacher Daniela , Pastore Friederike , Bräundl Kathrin , Zellmeier Evelyn , Ksienzyk Bianka , Konstandin Nikola P. , Schneider Stephanie , Graf Alexander , Krebs Stefan , Blum Helmut , Neumann Martin , Baldus Claudia D. , Bohlander Stefan K. , Wolf Stephan , Görlich Dennis , Berdel Wolfgang E. , Wörmann Bernhard J. , Hiddemann Wolfgang , Spiekermann Karsten 
Published: January 2018

Abstract
Purpose: To study mechanisms of therapy resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on somatic alterations.
Experimental Design: We performed exome sequencing of matched diagnosis, remission, and relapse samples from 50 CN-AML patients treated with intensive chemotherapy. Mutation patterns were correlated with clinical parameters.
Results: Evolutionary patterns correlated with clinical outcome. Gain of mutations was associated with late relapse. Alterations of epigenetic regulators were frequently gained at relapse with recurring alterations of KDM6A constituting a mechanism of cytarabine resistance. Low KDM6A expression correlated with adverse clinical outcome, particularly in male patients. At complete remission, persistent mutations representing preleukemic lesions were observed in 48% of patients. The persistence of DNMT3A mutations correlated with shorter time to relapse.
Conclusions: Chemotherapy resistance might be acquired through gain of mutations. Insights into the evolution during therapy and disease progression lay the foundation for tailored approaches to treat or prevent relapse of CN-AML. Clin Cancer Res; 24(7); 1716–26. ©2018 AACR.
Valuing Time-Varying Attributes Using the Hedonic Model: When Is a Dynamic Approach Necessary?
Authors: Bishop Kelly C. , Murphy Alvin D. 
Published: January 2018

Abstract
We build on the intuitive (static) modeling framework of Rosen (1974) and specify a simple, forward-looking model of location choice. We use this model, along with a series of graphs, to describe the potential biases associated with the static model and relate these biases to the time series of the amenity of interest. We then derive an adjustment factor that allows the potentially biased static estimates to be converted into forwardlooking estimates. Finally, we illustrate these concepts with two empirical applications: the marginal willingness to pay to avoid violent crime and the marginal willingness to pay to avoid air pollution.
The prevalence and burden of mental and substance use disorders in Australia: Findings from the Global Burden of Disease Study 2015
Authors: Ciobanu Liliana G , Ferrari Alize J , Erskine Holly E , Santomauro Damian F , Charlson Fiona J , Leung Janni , Amare Azmeraw T , Olagunju Andrew T , Whiteford Harvey A , Baune Bernhard T 
Published: January 2018

Objectives: Timely and accurate assessments of disease burden are essential for developing effective national health policies. We used the Global Burden of Disease Study 2015 to examine burden due to mental and substance use disorders in Australia. Methods: For each of the 20 mental and substance use disorders included in Global Burden of Disease Study 2015, systematic reviews of epidemiological data were conducted, and data modelled using a Bayesian meta-regression tool to produce prevalence estimates by age, sex, geography and year. Prevalence for each disorder was then combined with a disorder-specific disability weight to give years lived with disability, as a measure of non-fatal burden. Fatal burden was measured as years of life lost due to premature mortality which were calculated by combining the number of deaths due to a disorder with the life expectancy remaining at the time of death. Disability-adjusted life years were calculated by summing years lived with disability and years of life lost to give a measure of total burden. Uncertainty was calculated around all burden estimates. Results: Mental and substance use disorders were the leading cause of non-fatal burden in Australia in 2015, explaining 24.3% of total years lived with disability, and were the second leading cause of total burden, accounting for 14.6% of total disability-adjusted life years. There was no significant change in the age-standardised disability-adjusted life year rates for mental and substance use disorders from 1990 to 2015. Conclusion: Global Burden of Disease Study 2015 found that mental and substance use disorders were leading contributors to disease burden in Australia. Despite several decades of national reform, the burden of mental and substance use disorders remained largely unchanged between 1990 and 2015. To reduce this burden, effective population-level preventions strategies are required in addition to effective interventions of sufficient duration and coverage.
Barriers to the Adoption of Wearable Sensors in the Workplace: A Survey of Occupational Safety and Health Professionals
Authors: Schall Mark C. , Sesek Richard F. , Cavuoto Lora A. 
Published: January 2018

Objective: To gather information on the (a) types of wearable sensors, particularly personal activity monitors, currently used by occupational safety and health (OSH) professionals; (b) potential benefits of using such technologies in the workplace; and (c) perceived barriers preventing the widespread adoption of wearable sensors in industry. Background: Wearable sensors are increasingly being promoted as a means to improve employee health and well-being, and there is mounting evidence supporting their use as exposure assessment and personal health tools. Despite this, many workplaces have been hesitant to adopt these technologies. Methods: An electronic survey was emailed to 28,428 registered members of the American Society of Safety Engineers (ASSE) and 1,302 professionals certified by the Board of Certification in Professional Ergonomics (BCPE). Results: A total of 952 valid responses were returned. Over half of respondents described being in favor of using wearable sensors to track OSH-related risk factors and relevant exposure metrics at their respective workplaces. However, barriers including concerns regarding employee privacy/confidentiality of collected data, employee compliance, sensor durability, the cost/benefit ratio of using wearables, and good manufacturing practice requirements were described as challenges precluding adoption. Conclusion: The broad adoption of wearable technologies appears to depend largely on the scientific community’s ability to successfully address the identified barriers. Application: Investigators may use the information provided to develop research studies that better address OSH practitioner concerns and help technology developers operationalize wearable sensors to improve employee health and well-being.
Who should be responsible for supporting individuals with mental health problems? A critical literature review
Authors: Pope Megan A , Malla Ashok K , Iyer Srividya N 
Published: January 2018

Background: Individuals with mental health problems have many support needs that are often inadequately met; however, perceptions of who should be responsible for meeting these needs have been largely unexplored. Varying perceptions may influence whether, how, and to what extent relevant stakeholders support individuals with mental health problems. Aims: To critically evaluate the literature to determine who different stakeholders believe should be responsible for supporting individuals with mental health problems, what factors shape these perceptions, and how they relate to one another. Method: A critical literature review was undertaken. Following an extensive literature search, the conceptual contributions of relevant works were critically evaluated. A concept map was created to build a conceptual framework of the topic. Results: Views of individual versus societal responsibility for need provision and health; the morality of caring; and attributions of responsibility for mental illness offered valuable understandings of the review questions. Creating a concept map revealed that various interrelated factors may influence perceptions of responsibility. Conclusions: Varying perceptions of who should be responsible for supporting individuals with mental health problems may contribute to unmet support needs among this group. Our critical review helps build a much-needed conceptual framework of factors influencing perceptions of responsibility. Such a framework is essential as these views iteratively shape and reflect the complex divisions of mental healthcare roles and responsibilities. Understanding these perceptions can help define relevant stakeholders’ roles more clearly, which can improve mental health services and strengthen stakeholder accountability.
Beyond size: Overcoming fragmentation by inter-municipal associations in Spain? The case of Catalonia
Authors: Pano Puey Esther , Magre Ferran Jaume , Puiggròs Mussons Carla 
Published: January 2018

The Spanish local system is characterised by strong fragmentation and a large number of local territorial entities. One of the possible ways of compensating for this small size is through associations of municipalities, which may empower their members to provide better services and may increase their ability to solve problems. However, the size of the municipalities may not be the only important factor. Indeed, other dimensions of size, such as the number of members or the size of the institution as an indicator of the degree of institutionalisation, can be taken into account. In this article, we explore the inter-municipal associations in an area of Spain (Catalonia) in order to identify and analyse the key factors and explanatory variables, and to explore different dimensions of the concept of size. Points for practitioners The size of the organisation is an important aspect of inter-municipal associations and it can be influenced by the number of municipalities and the area of cooperation. Upper-level-driven reforms may have a direct impact on the creation of these kinds of entities.