bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultraviolet light‐C increases antioxidant capacity of the strawberry (Fragaria x ananassa) in vitro and in high‐fat diet‐induced obese rats
Authors: Oviedo‐Solís Cecilia I. , Sandoval‐Salazar Cuauhtémoc , Lozoya‐Gloria Edmundo , Maldonado‐Aguilera Genaro A. , Aguilar‐Zavala Herlinda , Beltrán‐Campos Vicente , Pérez‐Vázquez Victoriano , Ramírez‐Emiliano Joel 
Published: June 2017

AbstractFlavonoids and polyphenols from the strawberry and other fruits have been proposed to reduce the oxidative stress produced by the obesity and her complications. Moreover, it has been proposed that irradiation with UV‐C to strawberry may increase the antioxidant capacity of this fruit. The aim of the present study was to explore the effects of the UV‐C on antioxidant capacity of strawberry in vitro and in vivo. Strawberry slices were irradiated with ultraviolet light‐C (UV‐C) at 1.2 W/m2/16.5 min; then, the power antioxidant was isolated from the nonirradiated and irradiated strawberry slices into an organic phase, which was lyophilized to finally producing a nonirradiated strawberry extract (NSE) and UV‐irradiated strawberry extract (UViSE) powder. After the antioxidant capacity of both extracts were determined in vitro using the Trolox equivalent antioxidant capacity (TEAC) assay and in vivo using high‐fat diet‐induced obese rats. Our results demonstrated that irradiation with UV‐C to strawberry slices increased the antioxidants content, which was corroborated in vitro, where the antioxidant capacity of UViSE was higher than the NSE. However, in obese rats, the reduction in the oxidative damage by the UViSE and NSE were similar in peripheral tissues. Interestingly, the UViSE was better than the NSE to reduce the oxidative damage in brain. In conclusion, UV‐irradiation increases the antioxidants content of strawberry that is correlated with an increased antioxidant capacity in vitro, but in rats, this antioxidant capacity may be more effective in brain than in peripheral tissues.
The earliest Panamanian pottery: Reconstructing production and distribution of Monagrillo ceramics through petrographic provenance analysis
Authors: Iizuka Fumie 
Published: June 2017

AbstractMonagrillo pottery (ca. 4500‐3200 14C yr B.P.) is the earliest in Panama and one of the first ceramics in the New World. It is found in two distinct site types: (1) shell‐bearing middens of the northeastern Azuero Peninsula and (2) rock shelters of the Pacific plains, foothils, and cordillera, and the Caribbean slopes of central Panama. Here, I present a study that sources Monagrillo ceramics using petrography to distinguish locally produced from transported wares. Results indicate that ceramics were mainly produced in two zones: northeastern Azuero, and the Pacific slopes around Río Grande. Diachronic changes in ceramic sources were not observed. A number of vessels found in the Pacific plains rock shelters in the intermediate area were wares transported from both production zones. Most ceramics from the Caribbean slopes were manufactured on the Pacific slopes. As the first systematic pottery sourcing project conducted in Panama, this research provides the basis for future evaluations of degrees of sedentism, patterns of human mobility, and exchange, which can improve the knowledge of the context of ceramic origins in New World tropics.
Bitter Gourd Response to Surface and Subsurface Drip Irrigation under Different Fertigation Levels
Authors: Mali Santosh S. , Jha B.K. , Singh Ranveer , Meena Mukesh 
Published: June 2017

AbstractA 2‐year field experiment was conducted to investigate bitter gourd response to surface drip irrigation (DI, D0) and subsurface drip irrigation (SDI) at 5, 10 and 15 cm (D05, D10 and D15 respectively) in interaction with four fertigation levels (F1 50: 30: 30; F2 100: 60: 60; F3 120: 90: 90 and F4 150: 120: 120 kg NPK ha−1). It was observed that SDI having D10 and D15 treatments maintained a relatively drier soil surface and maintained higher soil water content in the crop root zone, providing more favourable conditions for plant growth. Vine length and fruit weight were less responsive to differences in lateral depth than marketable yield. Bitter gourd yield was significantly higher (21.9 and 21.2 t ha−1) under D10 and D15. At all fertigation levels, SDI recorded higher irrigation water productivity (IWP) over DI. Highest IWP (5.98 and 6.33 t ha−1 mm−1 in 2010–2011 and 2011–2012) was obtained under D10 treatments at the F4 level of fertigation. SDI fertigation level (F4) increased yields by increasing the mean weight of the fruits, and also by increasing fruit number. SDI with 10 cm depth of lateral placement and F4 level of fertigation is recommended as an optimum practice for improving yield and IWP of bitter gourd. Copyright © 2017 John Wiley & Sons, Ltd.
Development of a classification model for non‐alcoholic steatohepatitis (NASH) using confocal Raman micro‐spectroscopy
Authors: Yan Jie , Yu Yang , Kang Jeon Woong , Tam Zhi Yang , Xu Shuoyu , Fong Eliza Li Shan , Singh Surya Pratap , Song Ziwei , Tucker‐Kellogg Lisa , So Peter T. C. , Yu Hanry 
Published: June 2017

AbstractNon‐alcoholic fatty liver disease (NAFLD) is the most common liver disorder in developed countries [1]. A subset of individuals with NAFLD progress to non‐alcoholic steatohepatitis (NASH), an advanced form of NAFLD which predisposes individuals to cirrhosis, liver failure and hepatocellular carcinoma. The current gold standard for NASH diagnosis and staging is based on histological evaluation, which is largely semi‐quantitative and subjective. To address the need for an automated and objective approach to NASH detection, we combined Raman micro‐spectroscopy and machine learning techniques to develop a classification model based on a well‐established NASH mouse model, using spectrum pre‐processing, biochemical component analysis (BCA) and logistic regression. By employing a selected pool of biochemical components, we identified biochemical changes specific to NASH and show that the classification model is capable of accurately detecting NASH (AUC=0.85–0.87) in mice. The unique biochemical fingerprint generated in this study may serve as a useful criterion to be leveraged for further validation in clinical samples.
Cetuximab‐conjugated nanodiamonds drug delivery system for enhanced targeting therapy and 3D Raman imaging
Authors: Li Dandan , Chen Xin , Wang Hong , Liu Jie , Zheng Meiling , Fu Yang , Yu Yuan , Zhi Jinfang 
Published: June 2017

AbstractIn this study, a multicomponent nanodiamonds (NDs)‐based targeting drug delivery system, cetuximab‐NDs‐cisplatin bioconjugate, combining both specific targeting and enhanced therapeutic efficacy capabilities, is developed and characterized. The specific targeting ability of cetuximab‐NDs‐cisplatin system on human liver hepatocellular carcinoma (HepG2) cells is evaluated through epidermal growth factor receptor (EGFR) blocking experiments, since EGFR is over‐expressed on HepG2 cell membrane. Besides, cytotoxic evaluation confirms that cetuximab‐NDs‐cisplatin system could significantly inhibit the growth of HepG2 cells, and the therapeutic activity of this system is proven to be better than that of both nonspecific NDs‐cisplatin conjugate and specific EGF‐NDs‐cisplatin conjugate. Furthermore, a 3‐dimensional (3D) Raman imaging technique is utilized to visualize the targeting efficacy and enhanced internalization of cetuximab‐NDs‐cisplatin system in HepG2 cells, using the NDs existing in the bioconjugate as Raman probes, based on the characteristic Raman signal of NDs at 1332 cm−1. These advantageous properties of cetuximab‐NDs‐cisplatin system propose a prospective imaging and treatment tool for further diagnostic and therapeutic purposes.
High‐resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo
Authors: Zhang Pengfei , Li Lei , Lin Li , Hu Peng , Shi Junhui , He Yun , Zhu Liren , Zhou Yong , Wang Lihong V. 
Published: June 2017

AbstractPhotoacoustic computed tomography (PACT) is a non‐invasive imaging technique offering high contrast, high resolution, and deep penetration in biological tissues. We report a PACT system equipped with a high frequency linear transducer array for mapping the microvascular network of a whole mouse brain with the skull intact and studying its hemodynamic activities. The linear array was scanned in the coronal plane to collect data from different angles, and full‐view images were synthesized from the limited‐view images in which vessels were only partially revealed. We investigated spontaneous neural activities in the deep brain by monitoring the concentration of hemoglobin in the blood vessels and observed strong interhemispherical correlations between several chosen functional regions, both in the cortical layer and in the deep regions. We also studied neural activities during an epileptic seizure and observed the epileptic wave spreading around the injection site and the wave propagating in the opposite hemisphere.magnified image
Identification of Biomarkers for Early Diagnosis of Acute Myocardial Infarction
Authors: Ge Wen‐Han , Lin Yong , Li Sen , Zong Xuefeng , Ge Zhong‐Chun 
Published: June 2017

ABSTRACTAcute myocardial infarction (AMI) is a common disease with serious consequences in mortality and cost. Here we aim to screen the differentially expressed genes (DEGs) as biomarkers for early diagnosis of AMI. The microarray data of AMI was downloaded from Gene Expression Omnibus (GEO), including two independent types of research GSE66360 and GSE62646. The DEGs between control and processed samples were screened out by using limma package. Meanwhile, we performed functional analysis of GO terms and/or KEGG pathways to observe the enriched pathways of the DEGs. Finally, regression analysis of raw data was performed by using packet affyPLM in R language. Dataset GSE62646 contained 53 DEGs (FC log2>1 and P value <0.05) between first‐day samples from 28 STEMI patients and control samples from 14 patients without myocardial infarction history. There were 12 up‐regulated and 41 down‐regulated genes, 35 DEGs annotated. In GSE66360, a total of 3034 DEGs between 32 AMI patients and 38 healthy persons were obtained, including 1861 up‐regulated and 1173 down‐regulated DEGs. The comparison of the DEGs in two datasets revealed four common up‐regulated genes (EGR1, STAB1, SOCS3, TMEM176A). In enrichment analysis, STAB1, SOCS3, EGR1 involved in metabolic regulation and signaling pathways related to coronary artery disease with a characteristic change (P < 0.05). The DEGs, especially the four up‐regulated common genes, could serve as biomarkers for early diagnosis of AMI. Additionally, the relative biological pathways these DEGs enriched in might provide a good reference to explore the molecular expression mechanism of AMI. J. Cell. Biochem. 119: 650–658, 2018. © 2017 Wiley Periodicals, Inc.
Driving Aggression and Anxiety: Intersections, Assessment, and Interventions
Authors: Zinzow Heidi M. , Jeffirs Stephanie M. 
Published: June 2017

ObjectiveDriving aggression and anxiety are significant contributors to risky driving and motor vehicle crashes (MVCs), which are leading causes of U.S. morbidity and mortality. Even though aggression and anxiety can be conceptualized as related features of the fight‐or‐flight response, literature on these topics has not been integrated. Driving aggression and anxiety are also transdiagnostic constructs that span multiple psychiatric disorders. Assessment and treatment of these complex problems must be understood to reduce the public health burden of MVCs.MethodA comprehensive literature search was conducted using PsycInfo and Google Scholar.ResultsDefinitions and prevalence of constructs including driving anger, aggressive driving, posttraumatic stress disorder, driving phobia, and transdiagnostic factors are delineated. Psychosocial correlates and assessment instruments are reviewed. Theoretical models that explicate personological, affective, cognitive, and behavioral components are explored. Differential and shared processes underlying driving aggression and anxiety are examined. Interventions are described, with a focus on promising cognitive‐behavioral methods.ConclusionDriving aggression and anxiety likely share affective and cognitive characteristics such as emotional reactivity and distorted threat appraisals. Further research is needed to support theoretical models linking driving aggression and anxiety, and to validate assessment instruments that capture both constructs. Epidemiologic studies are needed to determine norms, prevalence, and clinical cutpoints. Integration of interventions for these interrelated problems could ultimately reduce risky driving and MVCs.
Do you know otitis media with ANCA‐Associated Vasculitis (OMAAV)?
Authors: Hisata Yoshio , Sasaki Eisuke , Ishimaru Koutaro , Harada Yousuke , Nakano Hirohumi , Naitou Shinji , Sugioka Takashi 
Published: June 2017

AbstractHearing loss is often the only symptom of OMAAV at initial presentation, thus making early diagnosis difficult. We present OMAAV in a 70‐year‐old woman with hearing loss and dry cough. Otoscopy showed otitis media with effusion. Audiometry showed mixed hearing loss, especially in the right ear. Serum myeloperoxidase antineutrophil cytoplasmic antibody was positive. Image analyses showed lung lesion and interstitial pneumonia, while bronchoscopy showed possible microscopic polyangiitis. After starting and tapering prednisolone, respiratory and otologic symptoms improved. When examining patients with acute otologic symptoms and suspected lung and/or renal disease, OMAAV should be included in differential diagnosis.
Effect of Betamethasone on Fetal Pulmonary and Umbilical Artery Doppler Velocimetry and Relationship With Respiratory Distress Syndrome Development
Authors: Güngör Emre Sinan , İlhan Gülşah , Gültekin Hüseyin , Zebitay Ali Galip , Cömert Serdar , Verit Fatma Ferda 
Published: June 2017

ObjectivesRespiratory distress syndrome (RDS) is a major cause of neonatal morbidity and mortality. It is primarily a disease of premature neonates. The aim of this study was to evaluate the impact of maternal betamethasone administration on the fetal pulmonary arteries (PAs) and umbilical arteries (UAs) and the correlation between RDS development and PA Doppler results.MethodsForty singleton pregnancies between 24 and 34 gestational weeks with a diagnosis of preterm birth were included prospectively. They received corticosteroids to enhance fetal lung maturity. Fetal PA and UA Doppler parameters were evaluated before and 48 to 72 hours after steroid administration. Maternal records were matched to neonatal charts, and demographic and outcome data were abstracted.ResultsThere were no differences between groups for maternal age, body mass index, mode of delivery, and mean GA at steroid administration. Apgar scores at 1 and 5 minutes were significantly lower for neonates who developed RDS (P < .05). There were no statistically significant differences in PA Doppler results between fetuses who developed RDS and those who did not, and there were no significant differences in PA Doppler results before and after steroid administration for both groups. The UA pulsatility and resistive indices were significantly lower after steroid administration for the neonates who developed RDS (P < .05).ConclusionsThere were no significant differences in PA Doppler indices for fetuses with or without RDS after steroid administration.
Sample size required to characterize area use of tracked seabirds
Authors: Thaxter Chris B. , Clark Nigel A. , Ross‐Smith Viola H. , Conway Greg J. , Bouten Willem , Burton Niall H. K. 
Published: June 2017

ABSTRACTConflicts in resource use between humans and wildlife populations are increasingly determined through quantitative approaches. To better understand interactions between birds and human activities in the marine environment, telemetry is routinely used to characterize the area use of species, but evaluations are often based on a small number of individuals taken as representative of a local population studied. Furthermore, the relative importance of the number of animals required and for what duration they should be tracked has received little attention. We examined the central‐place foraging movements of 24 lesser black‐backed gulls (Larus fuscus) from a protected population from 1 March to 31 August during 2010–2013. Using bootstrapping and non‐linear modeling, we investigated whether sample sizes were sufficient to characterize offshore area use by considering the cumulative area use for an increasing number of birds and duration of tracking. Box‐and‐whisker analysis suggested a minimum of 13 birds and a precautionary upper maximum of 41 birds were needed to describe 95% of the estimated area use of the population (defined by 100% occupancy). Tracking fewer birds for longer was more important than tracking more birds for less time. A period of 145 days was required to characterize area use for 13–41 birds; however, offshore areas were used primarily after May, meaning that a 97‐day tracking period from May onwards was also representative. Predicted and observed areas were strongly correlated, and the predicted area of 15 birds for 151 days was 91% of the total estimated for the population. These findings suggest that the data were suitable for determining interaction with offshore developments, and were characteristic of the population. This study has revealed the power of a long‐term tracking dataset, and has uncovered further complexities surrounding study design and analysis that may shape conclusions drawn. The method and considerations raised have wider applicability for other datasets where human‐wildlife resource use conflicts need to be assessed. © 2017 The Wildlife Society.
Effect of 1.5 wt% tin addition on the properties of AZ31 magnesium alloy
Authors: Mahallawy N. El , Akdesir M. , Palkowski H. 
Published: June 2017

AbstractIn this paper, 1.5 wt%Sn was added to the AZ31 magnesium alloy aiming at improving the mechanical properties by using a low cost alloying element. Both alloys were prepared in the cast/heat treated (HT), rolled at 350 °C, rolled/heat treated at 400 °C and extruded at 350 °C. The results indicate that with addition of tin an improvement was obtained in both tensile strength and ductility of the AZ31 alloy in the cast/heat treated and in the extruded conditions. The yield and ultimate tensile strengths reached 98 MPa and 224 MPa respectively with 14 % elongation in the cast/heat treated condition while in the extruded condition these values were 212 MPa and 286 MPa with 20 % elongation. The tensile strength was even higher after rolling reaching 315 MPa for AZ31 with tin addition; however, as the material temperature during the last passes has decreased to relatively low values, the % elongation decreased to 1 %. After heat treatment at 400 °C for 2 hours the % elongation was restored and reached 12 %; this was accompanied by a decrease in tensile strength which reached 276 MPa. The results are discussed in relation to the microstructure evolution including grain size, phase identification, and volume fraction of phases.
Synthesis and characterization of films based on cross linked blends of poly (vinylalcohol) and poly (vinylpyrrolidone) with glutaraldehyde for tissue engineering application
Authors: Pallavi P. , Kumar G. Mukesh 
Published: June 2017

AbstractIn these recent years, polymer blending is one of the significant interests by tissue engineering experts, since blending could produce biomaterials with enhanced physical and biological properties compare to the parent materials. In this context, present study aims at formation and characterization of polymeric blend of poly (vinylalcohol) and poly (vinylpyrrolidone) produced for tissue engineering application. Both polymers are blended at different concentrations to obtain films and nanofibers using solvent casting and electrospinning method respectively. The successful blending is confirmed by Fourier transform infrared spectroscopy, Field emission scanning electron microscope analysis and X‐ray diffraction. Later glutaraldehyde was added to chemically cross link the polymers and its effect was investigated on swelling and solubility properties of the blend. Experimental results reveal a relevant enhancement in the properties of poly (vinylalcohol) and poly (vinylpyrrolidone) blend when glutaraldehyde was added.
Salts Influence Cathechins and Flavonoids Encapsulation in Liposomes: A Molecular Dynamics Investigation
Authors: Laudadio Emiliano , Mobbili Giovanna , Minnelli Cristina , Massaccesi Luca , Galeazzi Roberta 
Published: June 2017

AbstractCathechins and flavonoids are responsible of numerous health benefits. Two of the most representatives’ compounds for their antioxidant and therapeutic effects are Epigallocatechin 3‐Gallate (EGCG), from green tea extracts, and morelloflavone (MF), from Garcinia dulcis. Here we explore, by atomistic Molecular Dynamics simulations, how EGCG and MF interact with lipid bilayers and we show the salts’ influence on their encapsulation degree in neutral liposomes. As a result, we found out that EGCGs naturally bind to the hydrophilic regions of phospholipids, positioning themselves mostly at the interface between water and lipid phases. The presence of a salt clearly influences the EGCG molecules’ absorption and the total effect depends strongly on the salt nature and concentration. Beside, for MF, we observed a high stability of the intermolecular MFs aggregates in water that strongly penalizes the flavonoid's interaction with the lipid polar heads. However, salts can influence MF′s liposomal penetration, even if they are not able to promote completely its absorption inside the bilayer. For both compounds, the increase of penetration is more marked in presence of magnesium chloride, whilst calcium chloride showed the opposite effect.
The Longitudinal Association Between Early Childhood Obesity and Fathers’ Involvement in Caregiving and Decision‐Making
Authors: Wong Michelle S. , Jones‐Smith Jessica C. , Colantuoni Elizabeth , Thorpe Roland J. , Bleich Sara N. , Chan Kitty S. 
Published: June 2017

ObjectiveFathers have increased their involvement in child caregiving; however, their changing role in childhood obesity is understudied. This study assessed the longitudinal association between changes in obesity among children aged 2 to 4 years and changes in fathers' involvement with raising children.MethodsLongitudinal data from the Early Childhood Longitudinal Study–Birth Cohort were used to conduct child fixed‐effects linear and logistic regression analyses to assess the association between changes in childhood obesity‐related outcomes (sugar‐sweetened beverage consumption, screen time, BMIzscore, overweight/obesity, obesity) and fathers' involvement with raising children (caregiving and influencing child‐related decisions). Fixed‐effects models control for all time‐invariant characteristics. Analyses were controlled for time‐varying confounders, including child age, maternal and paternal employment, and family poverty status.ResultsChildren whose fathers increased their frequency of taking children outside and involvement with physical childcare experienced a decrease in their odds of obesity from age 2 to age 4. Obesity‐related outcomes were not associated with fathers' decision‐making influence.ConclusionsIncreases in fathers' involvement with some aspects of caregiving may be associated with lower odds of childhood obesity. Encouraging fathers to increase their involvement with raising children and including fathers in childhood obesity prevention efforts may help reduce obesity risk among young children.