bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycoprotein Ibα inhibitor (CCP-224) prevents neutrophil-platelet aggregation in sickle cell disease
Authors: Jimenez Maritza A. , Novelli Enrico M. , Shaw Gray D. , Sundd Prithu 
Published: September 2017

Key Points
CCP-224 attenuates neutrophil-platelet aggregation in SCD patient blood. CCP-224 has the potential to prevent vaso-occlusion in SCD patients.
A High-Order Difference Scheme for the Space and Time Fractional Bloch–Torrey Equation
Authors: Zhu Yun , Sun Zhi-Zhong 
Published: September 2017

Abstract
In this paper, a high-order difference scheme is proposed for an one-dimensional space and time fractional Bloch–Torrey equation.
A third-order accurate formula, based on the weighted and shifted Grünwald–Letnikov difference operators, is used to approximate the Caputo fractional derivative in temporal direction.
For the discretization of the spatial Riesz fractional derivative, we approximate the weighed values of the Riesz fractional derivative at three points by the fractional central difference operator.
The unique solvability, unconditional stability and convergence of the scheme are rigorously proved by the discrete energy method.
The convergence order is 3 in time and 4 in space in

L
1

⁢

(

L
2

)

{L_{1}(L_{2})}

-norm.
Two numerical examples are implemented to testify the accuracy of the numerical solution and the efficiency of the difference scheme.
About tests of the “simplifying” assumption for conditional copulas
Authors: Derumigny Alexis , Fermanian Jean-David 
Published: September 2017

Abstract
We discuss the so-called “simplifying assumption” of conditional copulas in a general framework. We introduce several tests of the latter assumption for non- and semiparametric copula models. Some related test procedures based on conditioning subsets instead of point-wise events are proposed. The limiting distributions of such test statistics under the null are approximated by several bootstrap schemes, most of them being new. We prove the validity of a particular semiparametric bootstrap scheme. Some simulations illustrate the relevance of our results.
The relative effects of isolated and combined structured input and structured output on the acquisition of the English causative forms
Authors: Benati Alessandro , Batziou Maria 
Published: September 2017

AbstractThe present study explores the effects of structured input and structured output when delivered in isolation or in combination on the acquisition of the English causative. Research investigating the effects of processing instruction and meaning output-based instruction has provided some interesting and sometimes conflicting results. Additionally, there are a number of issues (e. g., measuring a combination of structured input and structured output, measuring discourse-level effects) that have not been fully and clearly addressed. To provide answers to the questions formulated in this study, two classroom experiments were carried out. In the first study, fifty-four Chinese university students (age 18–20) participated. The participants were randomly assigned to four groups: structured input only group (n=13); structured output only group (n=15); combined structured input and structured output group (n=16); control group (n=10). In the second study, thirty school-age Greek learners (age 10–12) participated. The participants were randomly assigned to three groups: structured input only group (n=10); structured output only group (n=10); combined structured input and structured output group (n=10).Only subjects who participated in all phases of each experiment and scored lower than 60 % in the pre-tests were included in the final data collection. Instruction lasted for three hours. The control group received no instruction on the causative structure. Interpretation and production tasks were used in a pre-test and post-test design. The design included a delayed post-test battery (3 weeks after instruction) for both experiments. In the first study, the assessment tasks included an interpretation and production task at sentence-level, and an interpretation task at discourse-level. In the second study, an additional discourse-level production task was adopted along with the interpretation discourse-level task. The results indicated that learners who received structured input both in isolation and in combination benefitted more than learners receiving structured output only. These two groups were able to retain instructional gains three weeks later in all assessment measures.
Performance Risks Allocation in Bot Infrastructure in Nigeria: A Case Study of Lagos Infrastructure Project
Authors: Sanni Gabriel A. , Adebiyi John O. 
Published: September 2017

Abstract
The study assessed allocation, criteria and allotment effectiveness of performance risks in Build- Operate-Transfer (BOT) transportation infrastructure in Nigeria using Lagos Infrastructure Project (LIP) as a case study. LIP is the only BOT-procured tolled road that has attained ‘operate’ stage of BOT cycle in Nigeria. It revealed that more operating risks were actually allocated to the concessionaire than the grantor and most of the risks were preferred retained by the allottee. Significant fraction of the risks was effectively allocated between the concessionaire and grantor except those that involve close interface between participants. While grantor rated nine risks high and seven risks very high; the concessionaire assessed nine risks to be high and five risks to be very high; the grantor rated the effectiveness level to be seventy three per cent and the concessionaire assessed it to be sixty four per cent. The study recommended that the evolving knowledge from Lagos Infrastructure Project (LIP) should be documented to guide future BOT transactions in Nigeria.
Evaluation of a Process Monitoring Method for Compounding Parenteral Nutrition with the Baxter EM2400 in a Hospital Pharmacy Department
Authors: Collins Chelsey , Krämer Irene 
Published: September 2017

AbstractBackgroundA method for process monitoring of the Baxter ACD, Exactamix EM2400, by chemically analyzing the concentrations of the ingredients in parenteral nutrition test preparations was evaluated.MethodsIn the study, three different test preparations were developed consisting of four ingredients varying in volume and concentration, which simulated actual PN products. Each test preparation was produced in triplicate by a trained pharmacy technician using the Exactamix EM2400 from Baxter (Baxter International Inc.). The process was repeated on three consecutive days using the same conditions. The amount of each ingredient in the test preparation was measured in an external contract laboratory using European Pharmacopoeia methods. Based on USP monographies and the Guidelines on the Safe Use of Automated Compounding Devices for the Preparation of Parenteral Nutrition from the ASHP the device was tested to be accurate to deliver within 5 % of the amount programmed.ResultsThe study showed that in most cases the ingredient delivery of the automated compounder deviated less than 3 % from the expected concentrations. For certain ingredients out of specification results were detected and analyzed. By resetting the flow factor, it was possible to optimize the performance of the ACD.ConclusionThe study emphasizes the need for process monitoring of the Exactamix EM2400 during the initial installation and on a regular basis for each ingredient to ensure the accurate delivery of ingredients. Further methods need to be analyzed to determine the most feasible method to regularly conduct process monitoring tests on an ACD in a hospital pharmacy setting.
Exercise Technique: Applying the Hexagonal Bar to Strength and Power Training
Authors: Lockie Robert G. , Lazar Adrina 
Published: September 2017

ABSTRACT
THE HEXAGONAL (HEX) BAR CAN OFTEN BE FOUND IN TRAINING FACILITIES; THIS ARTICLE WILL DESCRIBE HOW THIS EQUIPMENT COULD BE INCORPORATED IN THE STRENGTH AND POWER TRAINING OF ATHLETES. THE UNIQUE BAR DESIGN MEANS THAT THE HEX BAR COULD BE USED FOR DIFFERENT EXERCISES, INCLUDING THE DEADLIFT, FARMER'S WALK, AND JUMP SQUAT. THE LITERATURE REGARDING THESE EXERCISES WILL BE DISCUSSED, AND THIS INFORMATION WILL BE USED TO DEMONSTRATE PRACTICAL APPLICATION FOR THE STRENGTH AND CONDITIONING PROFESSIONAL. IN ADDITION, THE REQUIRED EXECUTION FOR THE LOW- AND HIGH-HANDLE HEX BAR DEADLIFT, HEX BAR FARMER'S WALK, AND HEX BAR JUMP SQUAT WILL BE DOCUMENTED.
Respiratory Infections and the Risk of Celiac Disease
Authors: Auricchio Renata , Cielo Donatella , de Falco Renato , Galatola Martina , Bruno Valentina , Malamisura Basilio , Limongelli Maria Giovanna , Troncone Riccardo , Greco Luigi 
Published: September 2017

BACKGROUND AND OBJECTIVES:
The increasing incidence of celiac disease (CD) suggests that common infections before the onset of autoimmune diseases could be an important factor in switching the immune response. We aimed to explore the relationship between early clinical events and the development of CD in genetically predisposed infants.

METHODS:
In this study, 373 newborns from families with at least 1 relative with CD were recruited, and human leukocyte antigen DQ2- or DQ8-positive infants were followed up with clinical and serological evaluations. Cross tabulation and odds ratios were used to explore the risk associated with single variables, and logistic regression analysis was performed to determine the variables that contributed to the risk of developing CD. Stepwise discriminant analysis was used to determine which variables could distinguish case patients from controls before diagnosis.

RESULTS:
The cumulative incidence of CD in this cohort was 6% at 3 years and 13.5% at 5 years of age, and l34 children (14%) developed CD before the sixth year of life. An analysis of adverse events showed a higher frequency of respiratory tract infections among CD patients during the first 24 months of life. In a stepwise discriminant analysis, which included sex and human leukocyte antigen risk class, only respiratory infections in the second and first years of life significantly contributed to discrimination of case patients versus controls.

CONCLUSIONS:
A multivariate model of discriminant analysis showed that the frequency of respiratory infections in the first 2 years of life could distinguish children who developed CD from those who did not.
Evaluación de la actitud del profesorado de educación física ante alumnos con Necesidades Educativas Especiales
Authors: Fernández-Rivas María , Espada Mateos María 
Published: September 2017

El estudio pretende conocer y analizar cómo es la actitud de los profesores de Educación Física ante alumnos con necesidades educativas especiales, relacionándolo con titulación y sociodemográfica. La metodología es cuantitativa y transversal, con una muestra de 40 profesores de la Comunidad de Madrid de Primaria y Secundaria. Para el análisis de los resultados se ha optado por un análisis bivariable a través de tablas de contingencia. Así, existen relaciones moderadas entre la variable actitud con la edad (Ø= .449), sexo (Ø= .411) y titulación (Ø= .422) siendo así siempre que Ø= .25- .5., llegando a la conclusión de que aún existe una actitud de rechazo ante estos alumnos.
Useful immunochromatographic assay of calprotectin in gingival crevicular fluid for diagnosis of diseased sites in patients with periodontal diseases
Authors: Kido Jun‐ichi , Murakami Shinya , Kitamura Masahiro , Yanagita Manabu , Tabeta Koichi , Yamazaki Kazuhisa , Yoshie Hiromasa , Watanabe Hisashi , Izumi Yuichi , Suda Reiko , Yamamoto Matsuo , Shiba Hideki , Fujita Tsuyoshi , Kurihara Hidemi , Mizuno Mitsuharu , Mishima Akihiro , Kawahara Nobumasa , Hashimoto Kazuhiro , Naruishi Koji , Nagata Toshihiko 
Published: September 2017

AbstractBackgroundCalprotectin, an inflammation‐related protein, is present in gingival crevicular fluid (GCF), and the determination of calprotectin is useful for diagnosing periodontal diseases. The authors have recently developed a novel immunochromatographic (IC) chip system to determine calprotectin levels in GCF. In the present study, the usefulness of this diagnostic system is investigated in patients with periodontal diseases.MethodsThirty‐six patients with periodontal diseases participated in this clinical test at multiple centers. Periodontitis sites (n = 118) and non‐periodontitis (healthy) sites (n = 120) were selected after periodontal examination. GCF collection and periodontal examination were performed at baseline, after supragingival and subgingival scaling and root planing. Calprotectin levels in GCF were determined using a novel IC chip system and evaluated as a visual score and an IC reader value. Correlations between GCF calprotectin levels, clinical indicators, and changes in calprotectin levels by periodontal treatments were investigated. Receiver operating characteristic (ROC) analysis of IC reader value for GCF calprotectin was performed to predict periodontal diseases.ResultsThe visual score of GCF calprotectin was highly correlated with the IC reader value. IC reader values of GCF calprotectin in the periodontitis group were higher than those of the healthy group at three dental examination stages, and they significantly decreased with periodontal treatments. Visual scores and IC reader values of GCF calprotectin were correlated to levels of clinical indicators. ROC analysis for GCF calprotectin showed an optimal cutoff value to predict periodontal diseases.ConclusionDetermination of GCF calprotectin using a novel IC chip system is useful for diagnosis of periodontal diseases.
Ekspresi mRNA LMP2A Epstein-Barr Virus dari Biopsi Jaringan dalam Blok Parafin Berpotensi sebagai Biomarka dalam Diagnosis Karsinoma Nasofaring
Authors: Afriansya Roni , Pramono Hendro , Sulistyo Hidayat , Wahyono Daniel Joko 
Published: September 2017

Karsinoma nasofaring (KNF) merupakan tumor epitel yang terletak di nasofaring dan merupakan penyakit genetik multifaktor yang endemik. Penyebab utama KNF adalah infeksi oleh Virus Epstein-Barr (EBV). Keberadaan EBV pada penderita KNF dapat diketahui dengan ditemukannya DNA EBV dalam spesimen biopsi jaringan penderita KNF. Genom EBV dan ekspresi sebagian dari produk gen laten virus secara konsisten terdeteksi hampir di setiap sel dalam kanker ini, salah satunya adalah gen Latent Membrant Protein (LMP). Aktivitas mRNA EBV lebih mencerminkan patogenesis KNF yang sesungguhnya dari pada diagnosis serologi dan pengukuran DNA EBV di sirkulasi. Penelitian dilakukan di Laboratorium PA RSUD Margono Seokarjo, Purwokerto/Lab PA Fakultas Kedokteran dan laboratorium genetika/molekuler Universitas Jenderal Soedirman Purwokerto. Analisis Ekspresi mRNA LMP2A EBV dengan teknik one step RT-PCR dan produk RT-PCR (amplikon cDNA) divisualisasi dengan elektroforesis gel agarosa 1%. Hasil ekspresi mRNA LMP2A EBV adalah 27,3% (6 dari 22 sampel). Kesimpulan, metode one step RT-PCR dapat digunakan untuk menganalisis ekspresi mRNA LMP2A EBV dari sampel biopsi jaringan KNF dalam blok paraffin dan hasil positivitas ekspresi mRNA LMP2A EBV sedang, sehingga berpotensi digunakan sebagai petanda biologi molekul diagnosis KNF.
Interaksi Makroalgae dan Lingkungan Perairan Teluk Carita Pandeglang
Authors: Kadi Achmad 
Published: September 2017

Makroalgae liar adalah flora perairan laut, tumbuh berada di paparan terumbu karang. termasuk dalam Chlorophyceae. Phaeophyceae dan Rhodophyceae, tumbuh Penelitian menggunakan metode transek quadrat pada October Tahun 20016. Setiap stasiun transek ditarik garis tegak lurus pantai. Hasil penelitian makroalgae di determinasi; kekayaan jenis, densitas dan interaksi makroalgae dengan temperatur, turbiditas, pH, salinitas serta oksigen terlarut. Makroalgae yang peroleh ada 18 jenis dengan nilai indeks keanekaragaman berada di Pantai Matahari Utara 0,219, Matahari Tengah 0,24 dan Matahari Selatan 0,213. Nilai indeks kemerataan tertinggi 0,240 berada di Matahari Tengah.Interaksi kekayaan dan kepadatan jenis berpengaruh dengan stasiun (Spearman rank rs = 0,521*; rs = 0,552* ) berada Matahari Tengah dan Matahari Utara. Intaraksi tertinggi makroalagae dengan faktor suhu (spearman rank rs = 0,687** ) sangat berpengaruh terhadap jenis Eucheuma spinosum.
Optimization of Empty Pallets Dispatching Based on Different Transportation Modes
Authors: Zhou Kang , He Shiwei , Song Rui , Yin Weichuan , Cheng Lingyan 
Published: September 2017

Abstract
In the pallet pool system, the differentiation of palletized freight volumes in different regions and seasonal transport of certain goods lead to the imbalance of pallets distribution among regions. It is necessary to improve the utilization of pallets through dispatching. The paper analyzes the factors which affect empty pallets dispatching, it includes carbon emission, transportation time and pallet type based on the pallet pool mode of enterprise alliance. On this basis, the optimization model is established with the goal of minimum total dispatching cost. Then, according to the different influences of railway and highway in transportation cost, the dispatching scheme is analyzed and the transportation mode of empty pallets dispatching is determined. Considering the characteristics of model, Cplex is used to solve it. Finally, a case is used to verify the feasibility and superiority of reasonable empty pallets dispatching in different transportation modes, and the transport characteristics of two transportation modes are analyzed. Moreover, the costs of pallets leasing and dispatching are compared.
Some Generalized Single Valued Neutrosophic Linguistic Operators and Their Application to Multiple Attribute Group Decision Making
Authors: Tan Ruipu , Zhang Wende , Chen Shengqun 
Published: September 2017

Abstract
This paper proposes a group decision making method based on entropy of neutrosophic linguistic sets and generalized single valued neutrosophic linguistic operators. This method is applied to solve the multiple attribute group decision making problems under single valued neutrosophic liguistic environment, in which the attribute weights are completely unknown. First, the attribute weights are obtained by using the entropy of neutrosophic linguistic sets. Then three generalized single valued neutrosophic linguistic operators are introduced, including the generalized single valued neutrosophic linguistic weighted averaging (GSVNLWA) operator, the generalized single valued neutrosophic linguistic ordered weighted averaging (GSVNLOWA) operator and the generalized single valued neutrosophic linguistic hybrid averaging (GSVNLHA) operator, and the GSVNLWA and GSVNLHA operators are used to aggregate information. Furthermore, similarity measure based on single valued neutrosophic linguistic numbers is defined and used to sort the alternatives and obtain the best alternative. Finally, an illustrative example is given to demonstrate the feasibility and effectiveness of the developed method.
Optimal Two-Part Tariff Licensing in a Differentiated Mixed Duopoly
Authors: Wang Jing , Yang Fangbai 
Published: September 2017

Abstract
This paper considers the two-part tariff licensing by an innovating firm to its potential competitor in a differentiated mixed duopoly, in which one firm sets a quantity and the other firm charges a price. Based on the development cost incurred by the rival, we derive the optimal behavior of the firms under full information case and partial information case respectively. Information difference on the equilibrium strategies is also investigated.
Petrophysical Quantification of Multiple Porosities in Shale-Petroleum Reservoirs With the Use of Modified Pickett Plots
Authors: Lopez Jimenez Bruno A. , Aguilera Roberto 
Published: September 2017

Summary
Previous petrographic work has shown that shale-petroleum reservoirs at discovery are characterized by a quad-porosity system. In this work, a petrophysical model is built that allows quantification of storage capabilities in shales through determination of adsorbed porosity (ϕads_c), organic porosity (ϕorg), inorganic porosity (ϕm), and fracture porosity (ϕ2). All these porosities are important because they provide reasonable input to physics-based numerical simulators for shale-petroleum reservoirs and thus more-realistic projections of reservoir performance and recoveries.
Pattern recognition is used in a modified Pickett plot for distinguishing key shale components such as total organic carbon (TOC) and level of organic metamorphism (LOM) and to distinguish between viscous and diffusion-like flow. Results from the model compare well with laboratory data.
The petrophysical model is easy to use, yet it is robust because it can handle at the same time the four porosities mentioned previously, but it can also handle simultaneously three, two, or only one of those porosities depending on the characteristics of the reservoir at a given depth.
It is concluded that the petrophysical model presented in this paper constitutes a valuable tool for physics-based characterization of shale-petroleum reservoirs.
La teoría de recursos y capacidades: un análisis bibliométrico
Authors: Fong Reynoso Carlos , Flores Valenzuela Karina Edith , Cardoza Campos Luz Melina 
Published: September 2017

Introducción: La Teoría de Recursos y Capacidades (TRC) constituye uno de los principales modelos teóricos que guían la investigación que se realiza en Gestión Estratégica, y su utilización es creciente. Esta tendencia, que inicia en los años ochenta del siglo pasado, se explica por distintos factores, entre los que destaca la aceptación, dentro de la comunidad académica asociada a la gestión estratégica, de argumentos de corte económico que se utilizan en este enfoque para explicar el comportamiento y desempeño de la empresa, y en particular, sus mecanismos de construcción y mantenimiento de la ventaja competitiva. La TRC considera que la disposición de una ventaja competitiva expresa que la empresa ha alcanzado un nivel de desempeño superior al de sus competidores, situación que le permite obtener beneficios extraordinarios, aún en el largo plazo. En este sentido, construir y sostener una ventaja competitiva constituye la clave del éxito de la empresa y señala la eficiencia con que la empresa utiliza sus recursos y capacidades. Método: Con el objetivo de verificar que las ideas antes señaladas correspondan con las publicaciones en el ámbito, se realiza un análisis de datos bibliométrico para el periodo 2011-2015 (agosto). En éste se identifican los principales tópicos de investigación que se tratan en la TRC, así como la tendencia que se sigue en su desarrollo. El énfasis está en identificar los trabajos más relevantes para su desarrollo, así como en sus principales autores.Resultados: Los datos obtenidos muestran una creciente generación de prueba empírica confirmatoria, el desarrollo de aplicaciones y la contribución de la TRC al desarrollo de otras disciplinas.Conclusión: El fortalecimiento y madurez de la TRC queda manifiesta a través de las publicaciones señaladas en este análisis de datos bibliométrico. Si bien el campo de la TRC es amplio y no permite profundizar en todas sus dimensiones, se puede concluir que los resultados obtenidos en este trabajo confirman que es correcta la percepción de la TRC como uno de los modelos teóricos más importantes para la investigación que se realiza en gestión estratégica.