bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Synthesis of an Oridonin‐Conjugated Iridium(III) Complex for the Intracellular Tracking of NF‐κB in Living Cells
Authors: Wang Wanhe , Yang Chao , Lin Sheng , Vellaisamy Kasipandi , Li Guodong , Tan Weihong , Leung Chung‐Hang , Ma Dik‐Lung 
Published: February 2017

AbstractNF‐κB is a critical transcription factor that plays an important role in mediating inflammation, the immune response, and cell proliferation. The activation of NF‐κB leads to an enhancement of proinflammatory mediator expression, which is implicated in the pathogenesis of a variety of diseases. Therefore, methods that allow the intracellular tracking of NF‐κB are particularly attractive because they can provide information regarding the pathways or stimulation responses that are involved in the activation of NF‐κB. In this work, we report a novel platform to track intracellular NF‐κB by employing the conjugated iridium(III) complex 1, which was synthesized through the unique combination of a luminescent iridium(III) moiety with the natural product oridonin. Experiments conducted with p50 knockdown cells revealed that complex 1 could detect the p50 subunit of NF‐κB in cellulo. Furthermore, complex 1 tracked NF‐κB translocation induced by tumor necrosis factor‐α (TNF‐α) as a model stimulus, without affecting the translocation process itself. To the best of our knowledge, complex 1 is the first metal‐based compound that has been reported to be capable of monitoring intracellular NF‐κB in living cells.
Reduction of cyclophosphamide dose for patients with subset 2 low‐risk rhabdomyosarcoma is associated with an increased risk of recurrence: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
Authors: Walterhouse David O. , Pappo Alberto S. , Meza Jane L. , Breneman John C. , Hayes‐Jordan Andrea , Parham David M. , Cripe Timothy P. , Anderson James R. , Meyer William H. , Hawkins Douglas S. 
Published: February 2017

BACKGROUNDFailure‐free survival (FFS) and overall survival (OS) rates were found to improve on Intergroup Rhabdomyosarcoma Study (IRS) IV (IRS‐IV) compared with IRS‐III for patients with subset 2 (IRS stage 1, group III nonorbit or stage 3, group I/II) low‐risk embryonal rhabdomyosarcoma with the addition of cyclophosphamide (total cumulative cyclophosphamide dose of 26.4 g/m2) to the combination of vincristine and dactinomycin (VAC). The goal of Children's Oncology Group ARST0331 for subset 2 low‐risk patients was to reduce the total cumulative cyclophosphamide dose without compromising FFS.METHODSTherapy included 4 cycles of VAC (total cumulative cyclophosphamide dose of 4.8 g/m2) followed by 12 cycles of vincristine and dactinomycin over 46 weeks. Patients with group II or III tumors received radiotherapy, except for girls with group III vaginal tumors who enrolled before September 2009 and achieved a complete response with chemotherapy with or without delayed surgical resection.RESULTSAmong 66 eligible patients who were followed for a median of 3.5 years, there were 20 failures versus 10.53 expected failures. The estimated 3‐year FFS and OS rates were 70% (95% confidence interval [95% CI], 57%‐80%) and 92% (95% CI, 83%‐97%), respectively. The estimated 3‐year FFS rate was 57% (95% CI, 33%‐75%) for girls with subset 2 genital tract embryonal rhabdomyosarcoma (21 patients) and 77% (95% CI, 61%‐87%) for all other subset 2 patients (45 patients) (P = .02).CONCLUSIONSThe authors observed suboptimal FFS among patients with subset 2 low‐risk rhabdomyosarcoma using reduced total cyclophosphamide. Eliminating radiotherapy for girls with group III vaginal tumors in combination with reduced total cyclophosphamide appeared to contribute to the suboptimal outcome. Cancer 2017;123:2368–2375. © 2017 American Cancer Society.
Supercritical CO2‐Assisted Reverse‐Micelle‐Induced Solution‐Phase Fabrication of Two‐Dimensional Metallic 1T‐MoS2 and 1T‐WS2
Authors: Tong Xin , Qi Yuhang , Chen Jing , Wang Nan , Xu Qun 
Published: February 2017

AbstractMetallic 1T phase molybdenum disulfide (MoS2) and tungsten disulfide (WS2) are both expected to exhibit promising catalytic activity, but they are highly unstable in nature. Exploring an efficient route to fabricate a high ratio of 1T‐MoS2 and 1T‐WS2 is highly desirable. Herein, for the first time, we report a two‐step process for synthesizing stable two‐dimensional (2D) metallic 1T phase MS2 nanosheets in the reverse‐micelle‐induced emulsion microenvironment with the assistance of supercritical CO2 (SC CO2). TEM, Raman and XPS characterizations demonstrate that the as‐prepared MoS2 nanosheets consist of 1T‐ and 2H‐phase, and the content of 1T phase is more than 90 %. The obtained 1T‐MoS2 exhibits excellent stability and good activity for the hydrogen evolution reaction. A potential of ≈330 mV at a current density of 10 mA cm−2 and a Tafel slope of 70 mV per decade were obtained for 1T‐MoS2. TEM and UV/Vis spectrum characterizations also testify that we have obtained 1T‐WS2. Thus this strategy utilizing a reverse‐micelle‐induced method for fabrication of 2D 1T‐MS2 can widen the potential applications in photoelectrocatalysis and photoelectronic devices.
Base transceiver station deployment using rectilinear distance location of a single facility
Authors: Ajibola T.M. , Surajudeen‐Bakinde N.T. , Amuda S.A.Y. 
Published: February 2017

SummaryThe huge amount of funds invested in deployment and installations of global satellite mobile infrastructures in Nigeria does not justify the poor quality of service (QoS) and network coverage experienced by the users in some areas while it is a gloomy issue as most of these infrastructures are grossly underused in other areas. The problem is majorly subjective to inappropriate location of the base transceiver stations (BTSs); hence, this work studied and analyzed an existing BTSs layout and proposes a model based on the use of median rule with rectilinear distance single facility location for appropriate deployment location of a new BTS that will ensure proper network connectivity and management of QoS for a given area. The case study is the University of Ilorin academic environment where transmission environmental monitoring system equipment was used to monitor the signals on the existing BTSs, to ascertain the positions of the existing BTSs, the total number of the existing BTSs, and areas of poor signal strengths for all the existing operators. The electric field intensity of each of the BTS sites was determined and was used as the weight in the rectilinear distance location model. The operator with the poorest signal strength was selected to occupy the new BTS so as to improve its handover and network connectivity.
Integrated load‐based power saving for real‐time and nonreal‐time traffic in LTE‐TDD
Authors: Yang Chun‐Chuan , Chen Jeng‐Yueng , Mai Yi‐Ting , Pan Zheng‐Ying 
Published: February 2017

SummaryLong‐Term Evolution (LTE) is a 4G wireless broadband technology developed by the Third Generation Partnership Project. Two duplex modes, namely, frequency division duplex and time division duplex (TDD), are defined in LTE for transmission in both downlink and uplink directions simultaneously. Power saving mechanisms for LTE‐frequency division duplex were proposed in the authors' previous work. Applicability of the previously proposed mechanisms to LTE‐TDD is investigated in this paper, and the idea of “virtual time” associated with the mapping mechanism from the virtual time domain to the actual time domain for different TDD configurations is proposed. With the help of the mapping mechanism, 3 revised power saving schemes are proposed to support real‐time user equipments and nonreal‐time user equipments in LTE‐TDD. Simulation study demonstrates the effectiveness of the mapping mechanism as well as the benefit of the proposed schemes in power saving efficiency and real‐time support in comparing with the standard‐based mechanism.
On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
Authors: Amin Ahmad , Chitsazan Mitra , Shiukhi Ahmad Abad Fatemeh , Taghavi Sepideh , Naderi Nasim 
Published: February 2017

AbstractAimsA considerable proportion of hospitalized patients for acute decompensated heart failure will be readmitted or die in short‐term follow‐up. In the present study, we aimed to assess the role of admission sodium (Na) and uric acid (UA) levels in the prediction of 30 day post‐discharge heart failure readmission or all‐cause mortality in advanced heart failure patients admitted with acute decompensation.Methods and resultsOne hundred and forty consecutive advanced heart failure patients who were admitted for a recent cardiac decompensation were enrolled in this prospective study. Serum Na and UA levels remained statistically unchanged during index admission (P = 0. 54 and 0.19, respectively). Within 30 days post‐discharge, composite end point of heart failure rehospitalization or all‐cause death occurred in 62 (44.3%) patients (event group). Length of stay was statistically similar between patients in the event and non‐event groups (P = 0.38). No correlations were also found between length of stay and left ventricular ejection fraction, serum Na, UA, erythrocyte sedimentation rate (ESR), high‐sensitivity C‐reactive protein (hs‐CRP), creatinine, and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP) levels (all P > 0.05). Lower left ventricular ejection fraction and Na and higher UA on admission were significantly associated with 30 day event both in univariate and multivariate analyses.ConclusionsGiven the predictive role of baseline Na and UA for early post‐discharge outcome and the absence of significant changes in their levels during initial hospitalization, admission Na and UA can be considered as prognosticators of acute decompensated heart failure, which their prognostic significance cannot be affected by routine acute heart failure therapy.
Histaminergic and non‐histaminergic elicited itch is attenuated in capsaicin‐evoked areas of allodynia and hyperalgesia: A healthy volunteer study
Authors: Andersen H.H. , Elberling J. , Sharma N. , Hauberg L.E. , Gazerani P. , Arendt‐Nielsen L. 
Published: February 2017

AbstractBackgroundChronic pain patients with sensitization may exhibit decreased sensitivity to normally pruritogenic sensory stimuli and moreover occasionally perceive these as painful. This study explored the relationship between itch and pain, by evaluating histaminergic and non‐histaminergic itch evoked in capsaicin‐induced allodynic and hyperalgesic areas.MethodsIn 28 healthy volunteers, capsaicin (100 μg/0.1 mL) was injected intradermally in the volar forearm to establish secondary dysesthesias. After the capsaicin‐induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25–40 spicules). The evoked itch and pain were recorded on a visual analogue scale (VAS0–10 cm). Contralateral injection of 0.1 mLisotonic saline served as a control.ResultsHistaminergic and non‐histaminergic evoked itch were significantly decreased when provoked in allodynic skin (p < 0.05). The area‐under‐the‐curve of the evoked itch was reduced −43% from 18.0 ± 2.6 cm10 minin normal skin to 10.3 ± 1.8 cm10 minin allodynic skin (p < 0.01) for cowhage and −56% from 20.0 ± 3.5 cm10 minin normal skin to 8.8 ± 2.3 cm10 minallodynic skin (p < 0.001) for histamine. The pain responses to the pruritogens were not significantly altered between the areas of allodynia and normal skin (p > 0.1). An additional experiment showed that pinprick hyperalgesia in the absence of allodynia was sufficient to evoke the observed reduced sensitivity to itch stimuli.ConclusionsCutaneous sensitization (secondary allodynia and hyperalgesia) reduced itch responses regardless of the type of itch model applied and without attenuation of the associated pruritogen‐induced pain responses. This could explain the decreased sensitivity to itch provocations previously observed in patients with chronic pain.SignificanceThis study shows that the neuronal sensitization processes underlying the development secondary hyperalgesia involve significant gating of histaminergic as well as non‐histaminergic pruriceptive transmission. Because these itch provocations normally target specific subpopulations of C‐nociceptors they could be of relevance for exploratory purposes in pain patients.
Electrochemical Detection of Nitrite Using Glassy Carbon Electrode Modified with Silver Nanospheres (AgNS) Obtained by Green Synthesis Using Pre‐hydrolysed Liquor
Authors: Shivakumar M. , Nagashree K. L. , Manjappa S. , Dharmaprakash M. S. 
Published: February 2017

AbstractSilver nanospheres (AgNS) with SPR band ∼417 nm was synthesized by Green synthesis, using a pre‐hydrolysed liquor (PHL) of Nilgiri wood without any pretreatment. The synthesis was carried out at room temperature and was complete within three hours. The reduction and stabilization of silver is brought about by hemicelluloses present in the pre‐hydrolysed liquor. Electrochemical oxidation of nitrite on glassy carbon electrode (GCE) modified with the AgNS in 0.1 M phosphate buffer solution (PBS) of pH 7.0 was found to occur at 0.86 V with respect to Ag/AgCl. Electrochemical sensing experiments with AgNS/GCE showed a linear range of detection between 0.1 to 8 μM, with detection limit of 0.031 μM and a sensitivity of 580 μA mM−1cm−2.
The Effect of Inlet Velocity on CH4 Catalytic Combustion Behavior with H2 Addition in a Microchannel Combustor
Authors: Yan Yunfei , Xu Qingyun , Tang Weimin , Huang Qiao , Zhang Li , Li Lixian , Yang Zhongqing 
Published: February 2017

AbstractThe characteristics of premixed methane/air combustion in a microchannel with a Pt catalyst were examined and the effect of inlet velocity on catalytic methane combustion with hydrogen addition was investigated numerically. It is shown that appropriate hydrogen addition can expand the extinction limits, particularly the upper extinction limit of the inlet velocity, and increase methane conversion at higher inlet velocities. However, it is proved that methane conversion at an equivalent ratio of 0.8 decreased with hydrogen addition when inlet velocity was lower than 0.36 m s−1. The heat released in the hydrogen–oxygen reaction increased the wall temperature, which resulted in the adsorption–desorption equilibrium of oxygen shifting towards desorption as Pt(s) coverage increased and O(s) coverage decreased. With the same amount of hydrogen added, the changes in wall temperature that reflected the thermal effects of hydrogen were more obvious at higher inlet velocities, which improved methane conversion. If the heat released by hydrogen was neglected, the competitive consumption of oxygen, which demonstrates the chemical effect of hydrogen, was more significant at lower inlet velocities, which inhibited methane conversion.
Sensitivity of seismic response for monitoring storage in a low porosity reservoir of the St Lawrence Lowlands, Québec, Canada: Part 1 – Laboratory measurements
Authors: Perozzi Lorenzo , Giroux Bernard , Schmitt Douglas R. , Gloaguen Erwan , Kofman Randy S. 
Published: February 2017

AbstractDeployment of carbon capture and storage on a large scale poses many challenges. One is the availability of reservoirs with suitable characteristics (high porosity and permeability, matched large emitters, etc.). Such a challenge might lead to the selection of reservoirs with relatively low porosity. In those environments, the rock matrix is often stiff and questions arise regarding the capabilities of seismic methods to monitor injection. In this paper, a series of ultrasonic measurements were performed under various pressure and temperature conditions to test the seismic response of two low‐porosity reservoir samples of the St Lawrence Lowlands sedimentary basin to different phases. Results show that the P‐wave velocity and amplitude can be used to detect the phase transition. Illustrative modeling of seismic reflectivities within a hypothetical geological formation with physical properties equal to that of the St Lawrence Lowlands sedimentary basin, suggests that a liquid‐water contact is a potentially good seismic reflector. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd.
Magnetic resonance imaging of the knee: An overview and update of conventional and state of the art imaging
Authors: Nacey Nicholas C. , Geeslin Matthew G. , Miller Grady Wilson , Pierce Jennifer L. 
Published: February 2017

Magnetic resonance imaging (MRI) has become the preferred modality for imaging the knee to show pathology and guide patient management and treatment. The knee is one of the most frequently injured joints, and knee pain is a pervasive difficulty that can affect all age groups. Due to the diverse pathology, complex anatomy, and a myriad of injury mechanisms of the knee, the MRI knee protocol and sequences should ensure detection of both soft tissue and osseous structures in detail and with accuracy. The knowledge of knee anatomy and the normal or injured MRI appearance of these key structures are critical for precise diagnosis. Advances in MRI technology provide the imaging necessary to obtain high‐resolution images to evaluate menisci, ligaments, and tendons. Furthermore, recent advances in MRI techniques allow for improved imaging in the postoperative knee and metal artifact reduction, tumor imaging, cartilage evaluation, and visualization of nerves. As treatment and operative management techniques evolve, understanding the correct application of these advancements in MRI of the knee will prove to be valuable to clinical practice.Level of Evidence: 5J. MAGN. RESON. IMAGING 2017;45:1257–1275
The diagnosis of pancreatic mucinous cystic neoplasm and associated adenocarcinoma in males: An eight‐institution study of 349 patients over 15 years
Authors: Ethun Cecilia G. , Postlewait Lauren M. , McInnis Mia R. , Merchant Nipun , Parikh Alexander , Idrees Kamran , Isom Chelsea A. , Hawkins William , Fields Ryan C. , Strand Matthew , Weber Sharon M. , Cho Clifford S. , Salem Ahmed , Martin Robert C.G. , Scoggins Charles R. , Bentrem David , Kim Hong J. , Carr Jacquelyn , Ahmad Syed A. , Abbott Daniel E. , Wilson Gregory , Kooby David A. , Maithel Shishir K. 
Published: February 2017

BACKGROUNDPer WHO, 2000 classification, pancreatic mucinous cystic neoplasms (MCN) are defined by presence of ovarian stroma, and are primarily located in the pancreatic body/tail of females. The incidence of MCN and associated malignancy in males, since, standardization of MCN diagnostic‐criteria is unknown.METHODSMCN resections from 2000 to 2014 at eight institutions of the Central‐Pancreas‐Consortium were included, and divided into early (2000‐2007) and late (2008‐2014) time‐periods. Primary aim was to characterize MCN and associated adenocarcinoma/high‐grade‐dysplasia (AC/HGD) in males versus females over time.RESULTSOf 1667 resections for pancreatic cystic lesions, 349 pts (21%) had MCNs: 310 (89%) female, 39 (11%) male. Patients were equally divided between early (n = 173) and late (n = 176) time‐periods. MCN in male‐patients decreased over time (early: 15%, late: 7%; P = 0.036), as did pancreatic head/neck location (early: 22%, late: 11%; P = 0.01). MCN‐associated AC/HGD was more frequent in males versus females (39 vs. 12%; P < 0.001). The overall rate of MCN‐associated AC/HGD remained stable (early: 17%, late: 13%; P = 0.4), and was identical in males (39%) over both time‐periods. Males with AC/HGD had more LN‐positive disease versus females (57 vs. 22%; P = 0.039).CONCLUSIONSAs the diagnostic‐criteria of MCN have standardized over time, MCN diagnosis has decreased in males and head/neck location. Despite this, MCN‐associated adenocarcinoma/high‐grade dysplasia has been stable and remains high in males. Any male with suspected MCN, regardless of location, should undergo resection.
Experimental results and fatigue life evaluation of magnesium laserbeam‐welded joints under proportional and non‐proportional multiaxial fatigue loading with variable amplitudes
Authors: Bolchoun A. , Sonsino C. M. , Kaufmann H. , Melz T. 
Published: February 2017

Fatigue life of magnesium laserbeam‐welds (AZ31 and AZ61 alloys) was assessed experimentally under variable amplitude loadings. The specimens were subjected to load‐controlled cyclic loadings. The tests were carried out using a Gauss‐distributed amplitude sequence of length LS = 5 · 104 cycles and loading ratio R = –1 under pure axial, pure torsion as well as in‐phase and out‐of‐phase combined loadings. The notch stresses were obtained from a linear‐elastic FE‐model using the reference radius approach with rref = 0.05 mm. The stress‐based hypotheses were applied: Effective equivalent stress hypothesis (EESH), shear stress intensity hypothesis (SIH), Findley, and modified Gough‐Pollard. A non‐proportionality factor is introduced and steps required for computing are presented in order to improve fatigue life assessment under non‐proportional loadings.
Carbon dioxide corrosion of carbon steel and corrosion inhibition by natural olive leaf extract
Authors: Pustaj G. , Kapor F. , Jakovljević S. 
Published: February 2017

The corrosion of carbon steel in carbon dioxide saturated chloride carbonate solution with and without olive leaf extract at 25 °C and 65 °C has been studied by linear polarization resistance technique, electrochemical impedance spectroscopy, scanning electron microscopy and Fourier transform infrared spectroscopy. In the absence of olive leaf extract, the corrosion products created under the testing conditions within 24 h at both testing temperatures have no significant protective properties. Measurements for uninhibited systems showed high corrosion current densities and low polarization resistances of carbon steel. Both linear polarization resistance technique and electrochemical impedance spectroscopy measurements reveal that olive leaf extract inhibits the carbon steel corrosion. The addition of a low‐concentration olive leaf extract decreases corrosion current densities, increases charge transfer and polarization resistance, resulting in more uniform and smoother steel surfaces. These effects are attributed to the adsorption of olive leaf extract on the carbon steel surface.
Energy–entropy–momentum integration schemes for general discrete non‐smooth dissipative problems in thermomechanics
Authors: Portillo D. , García Orden J. C. , Romero I. 
Published: February 2017

SummaryWe present the theory of novel time‐stepping algorithms for general nonlinear, non‐smooth, coupled, and thermomechanical problems. The proposed methods are thermodynamically consistent in the sense that their solutions rigorously comply with the two laws of thermodynamics: for isolated systems, they preserve the total energy and the entropy never decreases. Extending previous works on the subject, the newly proposed integrators are applicable to coupled mechanical systems with non‐smooth kinetics and can be formulated in arbitrary variables. The ideas are illustrated with a simple non‐smooth problem: a rheological model for a thermo‐elasto‐plastic material with hardening. Numerical simulations verify the qualitative features of the proposed methods and illustrate their excellent numerical stability, which stems precisely from their ability to preserve the structure of the evolution equations they discretize. Copyright © 2017 John Wiley & Sons, Ltd.