bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angina and associated healthcare costs following percutaneous coronary intervention: A real‐world analysis from a multi‐payer database
Authors: Ben‐Yehuda Ori , Kazi Dhruv S. , Bonafede Machaon , Wade Sally W. , Machacz Susanne F. , Stephens Leslie A. , Hlatky Mark A. , Hernandez John B. 
Published: January 2016

ObjectivesTo study the contemporary, real‐world clinical and economic burden associated with angina after percutaneous coronary intervention (PCI).BackgroundAngina adversely affects quality of life and medical costs, yet data on real‐world prevalence of angina following PCI and its associated economic consequences are limited.MethodsIn a multi‐payer administrative claims database, we identified adults with incident inpatient PCI admissions between 2008 and 2011 who had at least 12 months of continuous medical and pharmacy benefits before and after the procedure. Patients were followed for up to 36 months. Using claims, we ascertained post‐PCI outcomes: angina or chest pain, acute myocardial infarction, acute coronary syndrome, repeat PCI, healthcare service utilization, and costs.ResultsAmong 51,710 study patients (mean age 61.8, 72% male), post‐PCI angina or chest pain was present in 28% by 12 months and 40% by 36 months. Compared with patients who did not experience chest pain, angina or ACS, total healthcare costs in the first year after the index PCI were 1.8 times greater for patients with angina or chest pain ($32,437 vs. $17,913, P < 0.001). These cost differentials continued to 36 months.ConclusionsAngina after PCI is a frequent and expensive outcome. Further research is needed to identify risk factors and potentially improve outcomes for post‐PCI angina. © 2016 Wiley Periodicals, Inc.
Delayed left anterior mitral leaflet perforation and infective endocarditis after transapical aortic valve implantation—Case report and systematic review
Authors: Amat‐Santos Ignacio J. , Cortés Carlos , Varela‐Falcón Luis H. 
Published: January 2016

AimWe aimed to illustrate the physiopathology of anterior mitral leaflet perforation after TAVI in patients suffering from infective endocarditis (IE).Methods and ResultsThe first known case of balloon‐expandable transapical case from our series suffering from this complication was reported. In addition, a systematic electronic search of all published cases reporting both entities was performed. Five transfemoral cases have been published to the date, all males with mean age of 79.2 year (range: 66–88). Four were treated with self‐expandable prostheses (deeply implanted in the outflow tract). There was moderate residual aortic regurgitation in four. Fever and positive blood cultures for typical micoorganisms were present at certain time point in all cases between the first week and up to 11 months (early IE). Three cases underwent cardiac surgery with adequate outcomes and two others died during hospitalization. Medical management in the case from our series allowed patient's survival at 1‐year follow up.ConclusionsEarly suspicion of IE whenever anterior mitral perforation is found after TAVI can be life‐saving. The hypothetical higher risk of this complication due to higher rate of aortic regurgitation has to be prevented through adequate prosthesis depth and careful sterile surgical technique. © 2016 Wiley Periodicals, Inc.
Electroless Copper Plating on Liquid Crystal Polymer Films Using Dimethylamine Borane as Reducing Agent
Authors: Zhang Wenlong , Ding Dongyan 
Published: January 2016

AbstractDimethylamine borane (DMAB) was used in electroless copper plating on liquid crystal polymer (LCP) films. An orthogonal test was applied to optimize the plating condition. With Cu film resistivity as the evaluation index, the optimum plating condition is: 10 g/L of CuSO4 ⋅ 5H2O, 14 g/L of EDTA‐2Na, 6 g/L of DMAB, 9.5 of pH value and 50 °C. As pH value increases, the Cu film resistivity decreases and the depo‐ sition rate increases. As temperature increases, the Cu film resistivity decreases first and then increases with a minimum at 50 °C while the deposition rate increases first and then decreases with a maximum at 50 °C. The decreased Cu film resistivity can be attributed to the occurrence of CuO. The adhesive strength of copper layer to LCP film is constant at pH values lower than 8.5 and decreases slightly with the increase in pH value. As temperature increases, the adhesive strength decreases slightly. The decreased adhesive strength with both pH and temperature may be a result of an increased corrosion attack from the bath to the surface of LCP films. Low Cu film resistivity and high deposition rate as well as high adhesive strength can be obtained using DMAB reducing agent.
Assessment of pediatric obstructive sleep apnea using a drug‐induced sleep endoscopy rating scale
Authors: Lam Derek J. , Weaver Edward M. , Macarthur Carol J. , Milczuk Henry A. , O'Neill Eleni , Smith Timothy L. , Nguyen Thuan , Shea Steven A. 
Published: January 2016

Objectives/HypothesisAssess the reliability of a Sleep Endoscopy Rating Scale (SERS) and its relationship with pediatric obstructive sleep apnea (OSA) severity.Study DesignRetrospective case series of pediatric patients who underwent drug‐induced sleep endoscopy (DISE) at the time of surgery for OSA from January 1, 2013 to May 1, 2014.MethodsThree blinded otolaryngologists scored obstruction on DISE recordings as absent (0), partial (+1), or complete (+2) at six anatomic levels: nasal airway, nasopharynx, velopharynx, oropharynx, hypopharynx, and arytenoids. Ratings were summed for a SERS total score (range, 0–12). Reliability was calculated using a κ statistic with linear weighting. SERS ratings and obstructive apnea‐hypopnea index (OAHI) were compared using Spearman correlation. A receiver operating characteristic (ROC) analysis determined the ability of the SERS total score to predict severe OSA (OAHI >10).ResultsThirty‐nine patients were included (mean age, 8.3 ± 5.1 years; 36% obese; mean OAHI, 19.1 ± 23.7). Intrarater and inter‐rater reliability was substantial‐to‐excellent (κ = 0.61‐0.83) and fair‐to‐substantial (κ = 0.33‐0.76), respectively. Ratings correlated best with OAHI for the oropharynx (r = 0.54, P = .02), hypopharynx (r = 0.48, P = .04), and SERS total score (r = 0.75, P = .002). In ROC analysis, a SERS total score ≥6 demonstrated sensitivity/specificity of 81.8%/87.5%, respectively, and correctly classified 84% of patients.ConclusionsThe SERS can be applied reliably in children undergoing DISE for OSA. Ratings of the oropharynx, hypopharynx, and SERS total score demonstrated significant correlation with OSA severity. A SERS total score ≥6 was an accurate predictor of severe OSA.Level of Evidence4. Laryngoscope, 126:1492–1498, 2016
Congenital oval or round window malformations in children: Surgical findings and results in 17 cases
Authors: Vincent Robert , Wegner Inge , Derks Laura S. M. , Grolman Wilko 
Published: January 2016

Objectives/HypothesisTo prospectively evaluate surgical findings and hearing results in children undergoing surgery for congenital oval or round window malformations (class IV malformations).Study DesignA nonrandomized, nonblinded, case series of prospectively collected data.MethodsFourteen consecutive pediatric patients who underwent 17 surgical procedures for congenital oval or round window malformations in a tertiary referral center were included. Postoperative pure‐tone audiometry was available in 15 cases. The surgical technique for repair of the ossicular chain was dictated by the surgical findings at the time of surgery. The majority of the cases underwent ossiculoplasty using a Teflon piston, bucket‐handle prosthesis, or total ossicular replacement prosthesis. Associated surgical techniques included malleus relocation and oval window drill‐out procedure. The main outcome measures were preoperative and postoperative hearing status using four‐frequency (0.5, 1, 2, and 4 kHz) audiometry. Air‐conduction thresholds, bone‐conduction thresholds, and air‐bone gap were measured. Postoperative audiometry was performed at 3, 6, 9, 12, 18, and 24 months after surgery and at a yearly interval thereafter.ResultsPostoperative air‐bone gap closure to 10 dB or less was achieved in 47%. A postoperative air‐bone gap closure to within 20 dB or less was achieved in 60%. Postoperative sensorineural hearing loss did not occur in this series.ConclusionsMiddle ear surgery for class IV abnormalities is feasible, but success percentages are much lower compared to other types of congenital ossicular malformations. Surgeons should be particularly careful in case of facial nerve abnormalities on computed tomography or during middle ear exploration.Level of Evidence4 Laryngoscope, 126:2552–2558, 2016
Characterization of novel isobenzofuranones by DFT calculations and 2D NMR analysis
Authors: Teixeira Milena G. , Alvarenga Elson S. 
Published: January 2016

AbstractPhthalides are frequently found in naturally occurring substances and exhibit a broad spectrum of biological activities. In the search for compounds with insecticidal activity, phthalides have been used as versatile building blocks for the syntheses of novel potential agrochemicals. In our work, the Diels–Alder reaction between furan‐2(5H)‐one and cyclopentadiene was used successfully to obtain (3aR,4S,7R,7aS)‐3a,4,7,7a‐tetrahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one and (3aS,4R,7S,7aR)‐3a,4,7,7a‐tetrahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one (2) and (3aS,4S,7R,7aR)‐3a,4,7,7a‐tetrahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one and (3aR,4R,7S,7aS)‐3a,4,7,7a‐tetrahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one (3). The endo adduct (2) was brominated to afford (3aR,4R,5R,7R,7aS,8R)‐5,8‐dibromohexahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one and (3aS,4S,5S,7S,7aR,8S)‐5,8‐dibromohexahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one (4) and (3aS,4R,5R,6S,7S,7aR)‐5,6‐dibromohexahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one and (3aR,4S,5S,6R,7R,7aS)‐5,6‐dibromohexahydro‐4,7‐methanoisobenzofuran‐1(3H)‐one (5). Following the initial analysis of the NMR spectra and the proposed two novel unforeseen products, we have decided to fully analyze the classical and non‐classical assay structures with the aid of computational calculations. Computation to predict the 13C and 1H chemical shifts for mean absolute error analyses have been carried out by gauge‐including atomic orbital method at M06‐2X/6‐31+G(d,p) and B3LYP/6‐311+G(2d,p) levels of theory for all viable conformers. Characterization of the novel unforeseen compounds (4) and (5) were not possible by employing only the experimental NMR data; however, a more conclusive structural identification was performed by comparing the experimental and theoretical 1H and 13C chemical shifts by mean absolute error and DP4 probability analyses. Copyright © 2016 John Wiley & Sons, Ltd.
Risk of cancer among patients with depressive disorder: a meta‐analysis and implications
Authors: Ahn Hee Kyung , Bae Jeong Hun , Ahn Hong Yup , Hwang In Cheol 
Published: January 2016

AbstractObjectiveThe question of cancer risk in individuals with depression is unclear, primarily because of the heterogeneity of the assessment of depression in the published literature. To clarify the mixed findings, this analysis was limited to articles that used a reliable method of ascertaining depressive disorder.MethodsWe searched PubMed, EMBASE, and the Cochrane Library to identify studies investigating the effect of depression on subsequent risk of cancer, defining depression based on the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and/or the International Classification of Disease (ICD). We calculated a pooled odds ratio (OR) for developing cancer with the 95% confidence interval (CI).ResultsNine studies fulfilled the eligibility criteria. In a random‐effects model, patients with depressive disorder were at increased risk for cancer (OR, 1.26; 95% CI, 1.06–1.50, P = 0.01). However, a significant effect was observed only in low‐quality studies (OR, 1.31; 95% CI, 1.05–1.63, P = 0.018), and not in high‐quality studies (OR, 1.15; 95% CI, 0.85–1.56, P = 0.366).ConclusionOur results did not demonstrate that people with depressive disorder are at increased risk for developing cancer. Well‐designed prospective studies of recurrent or persistent depressive disorder that control for lifestyle factors including smoking are warranted. Copyright © 2016 John Wiley & Sons, Ltd.
Prohead RNA: a noncoding viral RNA of novel structure and function
Authors: Hill Alyssa C. , Bartley Laura E. , Schroeder Susan J. 
Published: January 2016

Prohead RNA (pRNA) is an essential component of the powerful Φ29‐like bacteriophage DNA packaging motor. However, the specific role of this unique RNA in the Φ29 packaging motor remains unknown. This review examines pRNA as a noncoding RNA of novel structure and function. In order to highlight the reasons for exploring the structure and function of pRNA, we (1) provide an overview of Φ29‐like bacteriophage and the Φ29 DNA packaging motor, including putative motor mechanisms and structures of its component parts; (2) discuss pRNA structure and possible roles for pRNA in the Φ29 packaging motor; (3) summarize pRNA self‐assembly; and (4) describe the prospective therapeutic applications of pRNA. Many questions remain to be answered in order to connect what is currently known about pRNA structure to its novel function in the Φ29 packaging motor. The knowledge gained from studying the structure, function, and sequence variation in pRNA will help develop tools to better navigate the conformational landscapes of RNA. WIREs RNA 2016, 7:428–437. doi: 10.1002/wrna.1330This article is categorized under:

RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry
RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems
THE DELINKING OF SEX AND MARRIAGE: PATHWAYS TO FERTILITY AMONG YOUNG FILIPINO WOMEN
Authors: Gipson Jessica D. , Hicks Andrew L. 
Published: January 2016

SummaryPartnership and fertility patterns of young Filipinos have changed dramatically from previous generations, with a widening gap between sexual initiation and marriage, and concurrent increases in teenage pregnancy and unwanted fertility. Further understanding of young adults’ social contexts and partnership patterns are needed to inform reproductive health programmes and policies affecting young Filipinos. Multivariate Poisson regression models were conducted with longitudinal and inter-generational data from the Cebu Longitudinal Health and Nutrition Survey (1998–2009) to examine the predictors of young women’s fertility. Age at first sex, and number and duration of partnerships each independently and significantly predicted women’s fertility by 2009 after controlling for contextual influences. Young women with more conservative attitudes towards dating, sex and marriage, and who perceived their mothers to have more conservative attitudes, had higher fertility than their peers, as did young women with mothers who reported more adolescent sexual behaviours. In contrast, fertility was lower among daughters who had higher levels of communication with their mothers. Given high levels of unintended fertility and teenage pregnancy in the Philippines, the findings indicate that the interval between sexual initiation and first and subsequent partnerships may be ideal intervention points for reproductive health services for young Filipinos.
n-3 Fatty acids and asthma
Authors: Kumar Aishwarya , Mastana Sarabjit S. , Lindley Martin R. 
Published: January 2016

AbstractAsthma is one of the most common and prevalent problems worldwide affecting over 300 million individuals. There is some evidence from observational and intervention studies to suggest a beneficial effect ofn-3 PUFA in inflammatory diseases, specifically asthma. Marine-basedn-3 PUFA have therefore been proposed as a possible complementary/alternative therapy for asthma. The proposed anti-inflammatory effects ofn-3 fatty acids may be linked to a change in cell membrane composition. This altered membrane composition followingn-3 fatty acid supplementation (primarily EPA and DHA) can modify lipid mediator generation via the production of eicosanoids with a reduced inflammatory potential/impact. A recently identified group of lipid mediators derived from EPA including E-series resolvins are proposed to be important in the resolution of inflammation. Reduced inflammation attenuates the severity of asthma including symptoms (dyspnoea) and exerts a bronchodilatory effect. There have been no major health side effects reported with the dietary supplementation ofn-3 fatty acids or their mediators; consequently supplementing withn-3 fatty acids is an attractive non-pharmacological intervention which may benefit asthma.
Life is determined by its environment
Authors: Torday John S. , Miller William B. 
Published: January 2016

AbstractA well-developed theory of evolutionary biology requires understanding of the origins of life on Earth. However, the initial conditions (ontology) and causal (epistemology) bases on which physiology proceeded have more recently been called into question, given the teleologic nature of Darwinian evolutionary thinking. When evolutionary development is focused on cellular communication, a distinctly different perspective unfolds. The cellular communicative-molecular approach affords a logical progression for the evolutionary narrative based on the basic physiologic properties of the cell.Critical to this appraisal is recognition of the cell as a fundamental reiterative unit of reciprocating communication that receives information from and reacts to epiphenomena to solve problems. Following the course of vertebrate physiology from its unicellular origins instead of its overt phenotypic appearances and functional associations provides a robust, predictive picture for the means by which complex physiology evolved from unicellular organisms. With this foreknowledge of physiologic principles, we can determine the fundamentals of Physiology based on cellular first principles using a logical, predictable method. Thus, evolutionary creativity on our planet can be viewed as a paradoxical product of boundary conditions that permit homeostatic moments of varying length and amplitude that can productively absorb a variety of epigenetic impacts to meet environmental challenges.
Policing and street triage
Authors: Cummins Ian , Edmondson David 
Published: January 2016

Purpose
– In his recent report, Lord Adebowale (2013) described mental health issues as “core police business”. The recent retrenchment in mental health and wider public services mean that the demands on the police in this area are likely to increase. Mental health triage is a concept that has been adapted from general and mental health nursing for use in a policing context. The overall aim of triage is to ensure more effective health outcomes and the more effective use of resources. The purpose of this paper is to examine the current policy and practice in this area. It then goes on to explore the models of mental health triage that have been developed to try and improve working between mental health services and the police.

Design/methodology/approach
– The paper outlines the main themes in the research literature regarding mental illness and policing, including a brief overview of section 136 MHA. It then examines recently developed models of triage as applied in these settings.

Findings
– The models of triage that have been examined here have developed in response to local organisational, demographic and other factors. The approaches have two key features – the improved training for officers and improved liaison with mental health services.

Practical implications
– Wider mental health training for officers and improved liaison with community-based services are the key to improving police contacts.

Social implications
– The current pressure on mental health services has increased the role that the police have in responding to these sorts of emergencies. This situation is unlikely to change in the short term.

Originality/value
– This paper contributes to the wider debate about policing and mental illness. It highlights the fact that section 136 MHA use has tended to dominate debates in this area to the detriment of a broader discussion of the police role.
Assessing the readiness of facilities management organizations in implementing knowledge management systems
Authors: Kamaruzzaman Syahrul Nizam , Zawawi Emma Marinie Ahmad , Shafie Muhaimin Ooyub , Mohd Noor Siti Nur Aishah 
Published: January 2016

Purpose
– This paper aims to assess the readiness of Malaysian facilities management (FM) organizations in implementing knowledge management (KM) systems.

Design/methodology/approach
– The questionnaire survey was used to retrieve information on the readiness of FM organizations in Malaysia.

Findings
– The findings reveal that, although many FM organizations were capable and ready in terms of information technology, lack of human behaviour and organizational policy is still seen. Technology, policy and human behaviour are the factors that have a strong influence on the successful outcome of KM.

Originality/value
– This paper fulfils an identified need to study in implementing KM systems.
Assessing impacts to Tennessee State Park infrastructure caused by extreme weather events
Authors: Abkowitz Brooks Kendra , Clarke James 
Published: January 2016

Purpose
– The purpose of this paper is to describe a risk-based methodology developed to identify the severity of impacts to various types of infrastructure located within the Tennessee State Park system when exposed to extreme weather events. Infrastructure systems, composed of various assets, are central to the economic, environmental and cultural functioning of the society. Understanding the potential impacts to these assets from various threats is fundamental to prudent strategic, operational and financial decision-making. Among infrastructure, systems of interest are those managed and operated by park services. Such systems are particularly exposed to extreme weather, given the recreational activities that they provide.

Design/methodology/approach
– This paper describes a risk-based methodology developed to identify the severity of impacts to various types of infrastructure located within the Tennessee State Park system when exposed to extreme weather events. It consists of the following steps: identifying extreme weather event types experienced in Tennessee; assessing damage to various types of park system infrastructure caused by these events; and deriving an overall impact score associated with specific types of park system infrastructure when exposed to certain types of extreme weather scenarios.

Findings
– In applying this methodology, tornadic events were found to be most impactful, whereas drought and heat events had the least effect on park infrastructure. Dining and lodging infrastructure were found to incur the most damage, regardless of the weather event type.

Originality/value
– The approach as described in this paper is transferable to other park systems as well as public sector assets in general.