bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and failure mechanism of landslides associated with seismic response of the slope during the 2022 Lushan Ms6.1 earthquake
Authors: Wu Haochen , Wang Yunsheng , He Jianxian , Luo Yonghong , Jin Gang , Song Huaying 
Published: October 2024

Abstract

In recent years, the frequent occurrence of intense seismic events in the mountainous regions of western China has led to numerous geological disasters, resulting in significant human casualties and extensive property damage. Understanding the seismic response of slopes is crucial for elucidating the failure mechanism of earthquake-induced landslides. The distribution of geological landslides and the seismic response of slopes in Lushan are examined through post-earthquake field investigations, landslides inventories, and comprehensive field monitoring. The landslides triggered by the earthquake were primarily concentrated along both banks of the Donghe River in Baoxing County, predominantly manifesting as rockfalls. Geological disasters are predominantly occurred along fault zones and water systems, where vulnerabilities are heightened near 1 km of these faults. The topographic features, lithological composition, and rock mass structure significantly influences the Peak Ground Acceleration (PGA). Notably, PGA experience a sudden increase in areas with slope breaks and loose soil layers, leading to initiation location of the landslide. In the monitoring profile, the PGA amplification factors increases significantly along the slope surface: PGA at the upper slope is 1 to 2 times greater than that of the hilltop reference point, and within the loose soil layer, it ranges from 1.5 to 3.0. Seismic waves in the 1–5 Hz frequency range are notably amplified in this profile, as evidenced by analysis of the Fourier spectrum and Horizontal to Vertical Spectral Ratio (HVSR) curve. The monitoring profile data reveals that site conditions have a pronounced influence on the amplitude of the acceleration, surpassing the magnification effects of terrain and elevation. In disaster investigations, deviations in the development of disasters from the epicentral area are observed, especially in regions with complex geological structures like nappe tectonics. In such cases, it is crucial to emphasize the impact of both the macroscopic and microscopic epicentershaode. Additionally, more attentions should be paid to understanding the seismic response of slopes, particularly concerning earthquake-triggered landslides.
Short Playful Interactions Improve Executive Functions in Children
Authors: Yaffe Daniela , Shtoots Limor , Isakow Omer Kochav , Daniel Yuval , Reuveni Omer , Shoshi Keisari , Golland Yulia 
Published: October 2024

Abstract

Executive Functions (EFs) are foundational for lifelong flourishing, supporting crucial capacities such as planning, decision-making, and self-regulation. Research indicates that EFs in children are malleable, with both long-term and short-term interventions facilitating the acquisition of these vital skills. Consequently, there is significant interest in enhancing EFs from early childhood. Social playfulness, a natural core aspect of children's lives, supports broad developmental benefits and may improve EFs. This study examined the effect of a short playful interaction compared with an active control interaction on children’s EF performance and mood. Sixty-two children aged 6 to 10 years participated in either a playful or control interaction with an adult female. The results showed that the playful interaction, but not the control interaction, improved attentional performance as measured with the Flanker task. Furthermore, playful interaction enhanced children’s positive mood and led to stronger social bonds with the co-player. These promising findings imply that playful interactions are multidimensional natural activities that target cognitive, emotional, and social functions simultaneously. We suggest that social playfulness holds unique potential for interventions aimed at training EFs in primary school children, as it is highly enjoyable and easy to learn and integrate into daily activities.
Non-Muscle Myosin Heavy Chain IIA regulates cell morphology, stress fibre structure and cell migration in FLO-1 oesophageal adenocarcinoma cells
Authors: Duff Deirdre , Gargan Siobhan , Long Aideen 
Published: October 2024

Abstract

The incidence of oesophageal adenocarcinoma (OAC) is increasing at a rapid rate in Western countries. Early oesophageal cancer is often asymptomatic and metastatic disease is common at presentation leading to poor prognosis and survival rates. Cell migration is tightly controlled in the healthy cell but can become dysregulated in diseases such as OAC where increased cell motility and migration can contribute to metastasis. We investigated the role of an actin-based molecular motor, non-muscle myosin heavy chain IIA (NMHCIIA) in the migratory capacity of oesophageal adenocarcinoma cells. Immunofluorescence microscopy and ratiometric imaging demonstrated that NMHCIIA co-localises with F-actin at the leading edge and retracting rear of migrating FLO-1 OAC cells. siRNA mediated depletion of NMHCIIA from FLO-1 cells altered cell morphology, gave rise to an increased number of stress fibre like structures and reduced FLO-1 cell migration. These findings suggest that NMHCIIA influences FLO-1 cell migration by regulating F-actin dynamics and the actin cytoskeleton, providing insight into the mechanisms of migration employed by OAC cells and identifying NMHCIIA as a potential therapeutic target for this disease.
Remnant Cholesterol as a Predictor of Cardiovascular Outcomes in Acute Coronary Syndrome Patients with Low-Density Lipoprotein Cholesterol Levels Below 1.8 mmol/L: Insights from the MPCS-ACS Study
Authors: Yang Hai-Tao , Yang Yi , Liu Jing-Kun , Zhang Jun-Shi , Zhang Jing 
Published: October 2024

Abstract

Aims: This study aimed to investigate the influence of remnant cholesterol (RC) on the risk of cardiovascular events in patients with acute coronary syndrome (ACS) who have tightly controlled low-density lipoprotein cholesterol (LDL-C) levels.
Methods: Analyzing data from the MPCS-ACS study, this investigation targeted individuals aged 18 to 79 diagnosed with ACS, who were admitted to three Chinese medical centers between June 2016 and May 2021, and who maintained LDL-C levels below 1.8 mmol/L.
Results: Out of 17,500 screened patients, 4,329 were analyzed. RC levels were calculated, with patients then categorized into quartiles. The primary focus was on all-cause and cardiovascular mortality. Secondary objectives involved assessing the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) as well as major adverse cardiovascular events (MACE). Through analysis of outcome events across different groups, coupled with multivariable adjustments and the use of restricted cubic splines, findings revealed that RC is a significant, independent risk factor for adverse outcomes in ACS patients when LDL-C levels are strictly controlled below 1.8 mmol/L, and this association remains significant even when LDL-C levels are further controlled below 1.4 mmol/L. Restricted cubic splines analysis illustrated a U-shaped, non-linear relationship between RC levels and endpoint events (all-cause and cardiovascular mortality, MACE, and MACCE), with the lowest risk observed at RC levels ranging from 0.29 to 0.45 mmol/L.
Conclusions: The study identifies RC as an independent risk factor for cardiovascular complications and highlights its U-shaped correlation with adverse outcomes.
Measurement of peripheral nerve magnetostimulation thresholds of a head solenoid coil between 200 Hz and 88.1 kHz
Authors: Barksdale Alex C. , Ferris Natalie G. , Mattingly Eli , Śliwiak Monika , Guerin Bastien , Wald Lawrence L. , Davids Mathias , Klein Valerie 
Published: October 2024

Abstract

Magnetic fields switching at kilohertz frequencies induce electric fields in the body that can cause peripheral nerve stimulation (PNS). Magnetically induced PNS, i.e. magnetostimulation, has been extensively studied below 10 kHz. It is widely characterized using a hyperbolic strength-duration curve (SDC), where the PNS thresholds monotonically decrease with frequency. The very few studies performed at higher frequencies found significant deviations from the hyperbolic SDC above ~ 25 kHz, however, those measurements are sparse and show large variability. We fill the gap in the data by measuring PNS in the head of 8 volunteers using a solenoidal coil at 16 frequencies between 200 Hz and 88.1 kHz. Contrary to the hyperbolic SDC, PNS thresholds did not decrease monotonically with frequency, but reached a minimum ~ 25 kHz. The thresholds then increased by 39% from 25 kHz to 88.1 kHz on average across subjects. Our measurements can be used for guidance and validation of neurodynamic models and to inform PNS limits of magnetic resonance imaging (MRI) gradient coils and magnetic particle imaging (MPI) systems. The observed deviation of the experimentally measured thresholds from the hyperbolic SDC calls for further study of the underlying biological mechanisms of magnetostimulation beyond 25 kHz.
The clinical value of the SII for predicting the development of urosepsis after percutaneous nephrolithotripsy
Authors: Wu Huang , Lian Fuyan 
Published: October 2024

Abstract

Purpose
Based on accumulating evidence, biomarkers related to the inflammatory response are closely associated with tumors. However, there are fewer studies related to urosepsis. The aim of this research was to investigate the importance of the SII as a predictor of the development of urosepsis after percutaneous nephrolithotripsy, utilizing a retrospective research design.
Materials and Methods
This study encompassed a cohort of 639 individuals diagnosed with kidney stones between January 2019 and August 2022. The patients were categorized into a modeling group consisting of 439 individuals and a validation group comprising 200 individuals, following a ratio of 7:3. R software was used to perform multivariate logistic regression analysis after screening with LASSO regression. The risk line graph model, ROC curve, calibration curve, and decision curve of the modeling group were drawn and visualized using R statistical software. These findings were also drawn and verified in the validation cohort.
Results
In a cohort of 439 patients, the prevalence of urosepsis was found to be 9.11% (40/439). Subsequently, a multivariate logistic regression analysis was conducted following a screening process utilizing LASSO regression. Our results suggested four risk factors for PCNL-US, namely, positive urinary nitrite (OR = 3.176, 95%CI: 1.390–7.097, P < 0.001), preoperative fever (OR = 2.762, 95%CI: 1.021–7.104, P = 0.039), positive urine culture (OR = 2.447, 95%CI: 1.077–5.476, P = 0.030), and high preoperative SII (OR = 4.943, 95%CI: 2.323–10.776, P < 0.001). According to above four factors, we constructed a column-line graph prediction model of risk factors for PCNL-US. The area under the ROC curve (AUC) of the modeling group was 0.818 (95% CI: 0.739–0.898). The area under the ROC curve (AUC) of the validation group was 0.794 (95% CI: 0.679–0.909). The Hosmer-Lemeshow test was greater than 0.05 in both groups, indicating a good calibration curve and good clinical decision-making performance.
Conclusions
This study suggested that positive urinary nitrite levels, preoperative fever, and positive urine culture are risk factors for PCNL-US. Additionally, a high preoperative SII level is recognized as a separate risk factor for the occurrence of urosepsis. The clinical prediction model constructed based on these four risk factors may serve as a reference for preventing the occurrence of PCNL-US.
MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH
Authors: Xiao Kui , Zhou Liangxue , Tang Xielin , Liu Shenghua , Deng Ziang , Yang Feilong 
Published: October 2024

Abstract

This study explores the specific magnetic resonance imaging (MRI) indicators of the brainstem and mesencephalic aqueduct in patients with idiopathic normal pressure hydrocephalus (iNPH). We analyzed the head MRI data of 50 iNPH patients and 30 healthy middle-aged and elderly individuals. The study included an analysis of the length, diameter, and angle of the cerebral aqueduct, as well as the longitudinal cross-sectional areas of the midbrain and brainstem. Additionally, we evaluated the midbrain proportion, brainstem volume ratio, the angle between the brainstem and spinal cord, and the area and morphology of the pontine cistern. The findings revealed that, compared to healthy individuals, iNPH patients exhibited significant dilation of the midbrain aqueduct diameter, a reduced aqueduct angle, and a decreased longitudinal cross-sectional area of the brainstem, with the most pronounced reduction in the midbrain area. Notably, the cerebral pools surrounding the brainstem in iNPH patients were dilated, with the pontine cistern presenting a "hammer" shape, and the prevalence of this "hammer" shape was significantly positively correlated with the area of the pontine cistern. These unique imaging characteristics not only enhance the clinical recognition of iNPH, but also provide new imaging evidence for the early diagnosis and treatment of iNPH.
Predicts Value of a Combined Nomogram Model Integrating ultrasound and cytology for ATA risk stratification of lymph node negative papillary thyroid carcinoma
Authors: Qin Xiachuan , LIU Xiaoling , He Fanding , Xiao Weihan , Ye Xianjun 
Published: October 2024

Abstract

Objectives
This study aimed to predict the American Thyroid Association (ATA) risk stratification of lymph node negative (N0) papillary thyroid carcinoma (PTC) patients using preoperative ultrasonic and cytological features to provide guidance for clinical treatment strategies.
Methods
In this multicenter, retrospective study, 500 N0 PTC patients who underwent total thyroidectomy with lymph node dissection were included across 2 institutions from September 2018 to February 2024. Patients were categorized into low, intermediate-high recurrence risk groups based on the 2009 ATA risk stratification system. Univariate logistic regression analysis was performed to assess the relationship between ultrasonic and cytological features and ATA risk stratification. Significant features (P < 0.05) were then incorporated into a multivariate logistic regression model to identify independent predictors of risk stratification. A Nomogram was constructed using predictors from the final multivariate logistic regression.
Results
Papillary like arrangement,Escape like arrangement, Nucleolus, Size, echo, Margin, and ECE were identified as independent predictors of ATA risk stratification. A Nomogram model was developed based on these predictors, demonstrating good discrimination with a C-index of 0.799. The calibration curve further demonstrated excellent predicted consistency between the predicted metastasis probabilities. Additionally, the Nomogram displayed a C-index of 0.778 in the testing cohort.
Conclusions
Risk stratification in N0 PTC patients correlates with factors such as Papillary arrangement, Escape like arrangement, Nucleolus, Size, Echo, Margin, and ECE, emphasizing the necessity of closely monitoring patients presenting with these risk factors. Additionally, the Nomogram model integrating seven preoperative risk factors specifically tailored for solitary N0 PTC patients was devised, showcasing notable predictive accuracy for preoperative ATA risk stratification.
Long-term Shoreline Dynamics of South Kerala Coast using Satellite images
Authors: S Shanmuga Priyaa , J Rajkumar , JENA BASANTA KUMAR 
Published: October 2024

Abstract

The shoreline experiences significant changes due to human activities and natural processes, resulting in erosion and accretion. Studying the morphology of shorelines is crucial for identifying the causes and impacts of coastal processes along the coast, which helps protect the ecosystem and facilitate future development. This study comprehensively analyses shoreline changes along the Kerala coast from 1973 to 2024, revealing substantial shifts due to frequent cyclones and other natural events. Key findings include significant erosion at Shangumugam, Valliyathura, Punthura, and Edapadu beaches and notable accretion at Thumba, Kochuveli, Vizhinjam, Adimalathura, Pullavila, Karumkulam, and Poovar. Trend analysis from 2000 to 2024, using high-resolution satellite images, identified consistent erosion patterns, particularly after Cyclone Ockhi in 2017, which caused significant, unrecovered erosion along the Vizhinjam coastline. It is observed that the frequency of cyclonic activity has increased in recent times. Validation of shoreline data derived from satellite images of varying resolutions (PAN (2.5m), LISS 4 (5m), MSI (10m)) against field data collected using DGPS demonstrated that higher spatial resolution results in more accurate shoreline extraction, with errors decreasing from 3.3m (10m vs. 1m) to 0.3m (2.5m vs. 1m). This highlights the importance of high-resolution satellite imagery in monitoring and managing shoreline changes. The study accentuates Kerala's increasing vulnerability to natural disasters and the necessity of advanced monitoring techniques for effective coastal management.
Impact of Lactobacillus johnsonii on Metabolic Control in Type 2 Diabetes with Circadian Disruption
Authors: Yang Yan , Wang zhen , Shen Hongxia , Shi Zhenhong , Mei Xianghui , Wu Na , Sun Li , Wang Defeng 
Published: October 2024

Abstract

Objective: In clinical practice, we have observed that most patients with type 2 diabetes mellitus (T2DM) and circadian rhythm disruption have poor blood glucose control. However, there is a subset of patients with T2DM and circadian rhythm disruption who still have good blood glucose control. Previous studies have shown that individuals with circadian rhythm disruption are more prone to developing T2DM, and the occurrence of T2DM is associated with the gut microbiota. However, the role of gut microbiota in patients with T2DM and circadian rhythm disruption remains unclear.
Methods: Stool samples were collected from 6 patients with poorly controlled type 2 diabetes mellitus (T2DM) and circadian rhythm disruption, as well as from 6 patients with well-controlled T2DM and circadian rhythm disruption. Metagenomic sequencing was performed on the stool samples. Compared to the well-controlled group, the abundance of Lactobacillus johnsonii(L. johnsonii ) was significantly decreased in the poorly controlled group. To investigate the effects of L. johnsonii supplementation on glucose and lipid metabolism, diabetic mice with circadian rhythm disruption were administered L. johnsonii and their metabolic indicators were measured.
Results: A metagenomic analysis is conducted in 6 patients with poorly controlled type 2 diabetes combined with disrupted circadian rhythm group (P-T2D-RD), as well as in 6 patients with well-controlled type 2 diabetes combined with disrupted circadian rhythm group (W-T2D-RD). Metagenomic sequencing of the gut microbiota revealed a higher microbial diversity in the W-T2D-RD group. Additionally, a significant decrease in the abundance of L. johnsonii was observed in patients with P-T2D-RD when compared to those with W-T2D-RD. Following supplementation of L. johnsonii to the mice in the type 2 diabetes mellitus rhythm disruption Lactobacillus johnsonii group (T2DM-RD-L), the fasting blood glucose levels and postprandial blood glucose levels were significantly reduced. Additionally, total cholesterol and low-density lipoprotein levels decreased, high-density lipoprotein levels increased in the T2DM-RD-L group.
Conclusion: Lactobacillus johnsonii has a positive impact on both glucose and lipid metabolism in patients with type 2 diabetes mellitus and circadian rhythm disruption.
N6-methyladenosine modification of circular RNA circASH2L suppresses growth and metastasis in hepatocellular carcinoma through regulating hsa-miR-525-3p/MTUS2 axis
Authors: Xu Dafeng , Liu Yachong , Liu Qiumeng , Li Ganxun , Zhang Lu , Yu Chengpeng , Liang Huifang , Chen Xiaoping , Zheng Jinfang , Song Jia 
Published: October 2024

Abstract

Background
CircRNAs have been demonstrated to play a crucial role in regulating the growth and progression of various cancers, including hepatocellular carcinoma (HCC). Nevertheless, the circRNA's expression pattern and function in HCC need more investigation.
Methods
Bioinformatics techniques were used to identify differentially expressed circRNAs in HCC. CircASH2L expression in HCC tissues was assessed through qRT-PCR and ISH analysis. To assess circASH2L's impact on HCC progression, a variety of experiments were carried out both in vitro and in vivo, such as CCK8, colony formation, EdU assay, flow cytometry, transwell assay, and xenograft mouse model. Various experimental techniques including qRT-PCR, dual luciferase reporter assay, FISH, RNA pull-down, and RIP experiments were utilized to evaluate the relationship between circASH2L, miR-525-3p, and MTUS2. Additionally, experiments were conducted to explore the impact of m6A modification on circASH2L expression, including RNA stability assay, m6A RNA immunoprecipitation assay (MeRIP), and Co-IP experiments.
Results
We found that circASH2L was downregulated in HCC tissues and the downregulation of circASH2L was significantly correlated with malignant characteristics as well as poor overall survival of patients with HCC. CircASH2L was found to inhibit cells growth, migration and invasion as well as tumorigenesis and metastasis in vivo. Mechanistically, we established that circASH2L directly interacted with miR-525-3p to enhance MTUS2 expression, subsequently leading to tumor suppression. Moreover, the influence of circASH2L on tumor suppression was attenuated by increasing miR-525-3p levels, and MTUS2 was recognized as an essential intermediary in circASH2L-induced tumor suppression. Additionally, N6−methyladenosine (m6A) modification was identified in circASH2L. Our data suggested that METTL3 was responsible for mediating m6A methylation of circASH2L, ultimately regulating circASH2L expression through the promotion of its degradation. These findings collectively highlight the role of circASH2L as a tumor suppressor through a unique circASH2L/miR-525-3p/MTUS2 axis, shedding light on the significance of m6A modification in regulating circASH2L function.
Conclusion
The work emphasizes circASH2L as a promising therapeutic target for treating HCC, offering new insights into the role of circRNAs in HCC development.
Utility of Tissue Biopsy in Amoxicillin-Clavulanate induced Concomitant Hepatic Failure and Renal Failure: A Case Report
Authors: Das John A. , Azad Saima , Kapp Meghan E. , Liu Wendy , Nguyen Vinh 
Published: October 2024

Abstract

Several reports indicate that amoxicillin-clavulanate can cause both liver injury as well as acute kidney injury. However, the majority of the existing literature has described liver-related injury, with fewer reports noting kidney injury. In this report, we describe a case of concomitant drug induced liver injury (DILI) and acute interstitial nephritis (AIN) as a result of amoxicillin-clavulanate exposure. A 62-year-old African American male presented with one week of generalized weakness, painless jaundice, nausea, vomiting, and diarrhea. Prior to admission, the patient had completed a 10-day course of amoxicillin-clavulanate for bacterial sinusitis. Upon admission, laboratory data revealed transaminitis and elevated creatinine levels suggestive of liver injury and renal failure. Through tissue biopsy of both organs, the diagnosis of amoxicillin-clavulanate induced acute liver injury and acute tubulointerstitial nephritis with bile cast nephropathy was made. This case highlights the critical role of tissue biopsy in reaching a unifying diagnosis for this rare adverse effect of amoxicillin-clavulanate.