bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracranial Aneurysm–Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis
Authors: Laarman Melanie D. , Vermunt Marit W. , Kleinloog Rachel , de Boer-Bergsma Jelkje J. , Brain Bank Netherlands , Rinkel Gabriël J.E. , Creyghton Menno P. , Mokry Michal , Bakkers Jeroen , Ruigrok Ynte M. 
Published: January 2018

Background and Purpose—
Genome-wide association studies significantly link intracranial aneurysm (IA) to single-nucleotide polymorphisms (SNPs) in 6 genomic loci. To gain insight into the relevance of these IA-associated SNPs, we aimed to identify regulatory regions and analyze overall gene expression in the human circle of Willis (CoW), on which these aneurysms develop.

Methods—
We performed chromatin immunoprecipitation and sequencing for histone modifications H3K4me1 and H3K27ac to identify regulatory regions, including distal enhancers and active promoters, in postmortem specimens of the human CoW. These experiments were complemented with RNA sequencing on the same specimens. We determined whether these regulatory regions overlap with IA-associated SNPs, using computational methods. By combining our results with publicly available data, we investigated the effect of IA-associated SNPs on the newly identified regulatory regions and linked them to potential target genes.

Results—
We find that IA-associated SNPs are significantly enriched in CoW regulatory regions. Some of the IA-associated SNPs that overlap with a regulatory region are likely to alter transcription factor binding, and in proximity to these regulatory regions are 102 genes that are expressed in the CoW. In addition, gene expression in the CoW is enriched for genes related to cell adhesion and the extracellular matrix.

Conclusions—
CoW regulatory regions link IA-associated SNPs to genes with a potential role in the development of IAs. Our data refine previous predictions on SNPs associated with IA and provide a substantial resource from which candidates for follow-up studies can be prioritized.
Quantifying Lateral Frontal Sinus Access: The Upper Blepharoplasty Approach
Authors: Steele Toby O. , Chin Oliver Y. , Kinzinger Michael R. , Strong E. Bradley 
Published: January 2018

Objective: Despite advances in technology and instrumentation, access to the lateral frontal sinus remains a challenge for surgeons. We sought to quantify the reach and applicability of the upper blepharoplasty approach (UBA) to the frontal sinus. Methods: Twelve cadaveric specimens were obtained for anatomic research and frontal sinuses divided into 3 zones. Zone 1 was defined as medial to the supraorbital neurovascular bundle (SON). The remaining orbit was then bisected to define zone 2 (centrally) and zone 3 (laterally). Twenty-four UBAs were performed followed by 12 modified endoscopic Lothrop procedures (MELP). The ability to instrument each wall of the frontal sinus was recorded for the MELP, UBA, and combined approach. Results: The UBA provided excellent access to the lateral frontal sinus in zones 2 and 3 (89% and 100%). The MELP provided poorer access in zone 3 (67%) but improved access in zone 1 (83%-100%). Access for zone 1 through the UBA was limited. The combined approach yielded 100% access to each frontal sinus boundary. Conclusion: The MELP in combination with the UBA/lateral trephination provides excellent access to each frontal sinus boundary. The UBA provides excellent access to the lateral frontal sinus but is limited medially by the SON.
Conservative Management for Subperiosteal Orbital Abscess in Adults: A 20-Year Experience
Authors: Gavriel Haim , Jabarin Basel , Israel Ofer , Eviatar Ephraim 
Published: January 2018

Objective: Orbital complications (OC) secondary to acute rhinosinusitis (ARS) in adults are less common than in children, with assumed worse outcome. Materials and Methods: Adults with OC secondary to ARS between 1994 and 2014 were reviewed retrospectively. Parameters recorded included age, gender, clinical symptoms and signs, computed tomography (CT) scan findings, duration of hospitalization, treatment before and during admission, cultures, and outcome. Results: Thirty-seven adults with a mean age of 34.6 years, 27 males and 10 females, were diagnosed with OC, 19 (51.3%) with subperiosteal orbital abscess (SPOA), and none with orbital abscess/cellulitis or cavernous sinus thrombosis. Twelve patients with SPOA were managed conservatively with Amoxicillin-Clavulanate in most cases, and only 7 (36.8%) underwent surgery. A CT scan was performed in 27 cases revealing rhinosinusitis in all patients, including frontal involvement in 19 (51.3%) patients and sphenoid sinus in 16 (43.2%). Conclusions: A shift toward conservative treatment in cases of SPOA has long been integrated in the management protocols, mainly in children under 9 years old. The presumed worse prognosis in adults is not supported in our study, and a conservative treatment is urged to be considered in this group of patients albeit the more extensive radiologic involvement of their sinuses.
A New Reversal Steps Stapedotomy
Authors: Malafronte Giuseppe 
Published: January 2018

Objective: To evaluate whether removal of the stapes head and not the entire stapes superstructure prevents footplate complications. Study Design: Prospective study. Patients: One hundred and forty-five patients with otosclerosis were included. Patients were divided into 2 groups as follows: Individuals in group 1 (n = 75) underwent removal of the entire stapes superstructure; individuals in group 2 (n = 70) underwent removal of the stapes head only. These 2 groups were further subdivided into 2 subgroups based on the type of otosclerosis. Group 1a included 55 cases of marginal otosclerosis, while group 1b included 15 diffusive and 5 biscuit otosclerosis cases. Group 2a included 51 marginal otosclerosis cases, while group 2b included 14 diffuse and 5 biscuit otosclerosis cases. Estimations were made regarding statistical correlation between type of reversal steps stapedotomy, otosclerosis type, incidence of footplate complications, and hearing results. Results: There were 9 footplate complications in group 1b and no complications in group 2b. This difference was significant. Air-bone gap closure to within 10 dB was achieved in 65% of cases in group 1b and 94.7% in group 2b. This difference was significant. Conclusion: The new stapedotomy prevented footplate complications and improved hearing results in diffuse and biscuit otosclerosis
Survival in Vivo Canine Phonation Model Without Stimulation
Authors: Liu Kena , Ge Pingjiang , Sheng Xiaoli , Jiang Jie , Qin Huabiao 
Published: January 2018

Objectives: We describe a survival nonstimulated in vivo canine phonation model using distending laryngoscope, cramp frame, and constant humidified glottal airflow to elicit phonation. Methods: Five beagle dogs were involved in this study. One cuffed endotracheal tube was placed below the glottis through the tracheotomy and delivered humidified airflow to the glottis. Arytenoids approximation was maintained using a clamp under the distending laryngoscope. Acoustic and aerodynamic parameters were measured using synchronous signal collection system and analysis software. Vocal oscillation also was examined using stroboscope laryngeal imaging. Results: For the nonstimulated in vivo phonation animal, the sound intensity and fundamental frequency were 78.3 ± 6.8 dB and 127.6 ± 29.2 Hz in the first experiment and 82.9 ± 6.6 dB and 175.2 ± 4.4 Hz 4 weeks later. The aerodynamic analysis revealed the mean subglottal phonation threshold pressure (PTP) and phonation threshold flow (PTF) were 8.5 ± 4.0 cmH20 and 683.0 ± 356.4 mL/s in the first experiment and 16.1 ± 8.6 cmH20 and 384.8.0 ± 230.6 mL/s in the second experiment 4 weeks later. Stroboscope image revealed sustained vocal vibration during great airflow delivery to glottis in the phonation animal model. Conclusions: We developed a survival nonstimulated in vivo phonation canine model that allows the study of long-term animal phonation study as its own control.
Possible role of stress, coping strategies, and life style in the development of breast cancer
Authors: Yıldırım Nazmiye K , Özkan Mine , İlgün Ahmet S , Sarsenov Dauren , Alço Gül , Aktepe Fatma , Kalyoncu Nesiba , İzci Filiz , Selamoğlu Derya , Ordu Çetin , Pilancı Kezban N , İyigün Zeynep E , Eralp Yeşim , Özmen Vahit 
Published: January 2018

Objective The aim of the present study was to investigate the possibility of the effect of life long stressful events, along with coping method used, perception of social support, and life style on the development of breast cancer. Methods In this hospital-based case control study, the study group comprised 250 women with breast cancer who were followed by Florence Nightingale Breast Study Group. Control group included 250 women, who had similar sociodemographic characteristics to the study group. Data were collected with semi-structured interview form, Healthy Life Style Behavior Scale, Coping Strategy Indicator, and Stress Evaluation Form developed by us. Results In multivariate analysis, family history of cancer (OR: 1.55, 95% CI: 2.29–1.05), inadequate social support (OR: 1.83, 95% CI: 1.23–2.73), and loss of father during childhood (OR: 2.68, 95% CI: 5.52–1.30) and serious stressor within the last five years (OR: 4.72, 95% CI: 7.03–3.18) were found to be risk factors increasing the risk of breast cancer. When family history of cancer was excluded from the model, the presence of psychiatric disorder history (OR: 1.95, 95% CI: 3.26–1.17) and major life events (OR: 2.24, 95% CI: 4.07–1.24) were added to the model as risk factors. Conclusion The present study indicates that especially the stressful events experienced within the last five years plays an undeniable role in the risk of breast cancer. Social support may be as important in the period before the diagnosis as in the period after diagnosis.
Factors influencing oil saturation and exploration fairways in the lower cretaceous Quantou Formation tight sandstones, Southern Songliao Basin, China
Authors: Xi Kelai , Cao Yingchang , Liu Keyu , Zhu Rukai 
Published: January 2018

Favorable exploration fairway prediction becomes crucial for efficient exploration and development of tight sandstone oil plays due to their relatively poor reservoir quality and strong heterogeneous oil saturation. In order to better understand the factors influencing oil saturation and favorable exploration fairway distribution, petrographic investigation, reservoir properties testing, X-ray diffraction analysis, oil saturation measurement, pressure-controlled mercury injection, and rate-controlled mercury injection were performed on a suite of tight reservoir from the fourth member of the Lower Cretaceous Quantou Formation (K1q4) in the southern Songliao Basin, China. The sandstone reservoirs are characterized by poor reservoir properties and low oil saturations. Reservoir properties between laboratory pressure conditions and in situ conditions are approximately the same, and oil saturations are not controlled by porosity and permeability obviously. Pores are mainly micro-scale, and throats are mainly nano-scale, forming micro- to nano-scale pore–throat system with effective connected pore–throat mainly less than 40%. Oil emplacement mainly occurs through the throats with average radius larger than 0.25 µm under original geological condition. Moreover, the samples with higher oil saturation show more scattered pore and throat distributions, but centered pore–throat radius ratio distribution. Pore–throat volume ratio about 2.3–3.0 is best for oil emplacement, forming high oil saturation. Quartz overgrowth, carbonate cements, and authigenic clays are the major diagenetic minerals. The reservoirs containing about 4–5% carbonate cements are most preferable for oil accumulation, and oil saturation increases with increasing of chlorite as well. The flow zone indicator is a reasonable parameter to predict favorable exploration targets in tight sandstone reservoirs. The reservoirs with flow zone indicator values larger than 0.05 can be regarded as favorable exploration targets in the K1q4 tight sandstones. According to the planar isoline of average flow zone indicator value, the favorable exploration targets mainly distribute in the delta plain distributary channel and deltaic front subaqueous distributary channel.
Prevalence of Obesity, Prediabetes, and Diabetes in Sexual Minority Men: Results From the 2014 Behavioral Risk Factor Surveillance System
Authors: Newlin Lew Kelley , Dorsen Caroline , Long Thomas 
Published: January 2018

Purpose The purpose of this study is to assess the prevalence and related odds ratios for obesity, prediabetes, and diabetes in sexual minority men (SMM) in relation to straight men. Methods A secondary analysis of 2014 Behavioral Risk Factor Surveillance System data from 19 states (n = 53 542) was conducted. Weighted means and standard errors were computed to estimate prevalence rates of obesity, prediabetes, and diabetes across male sexual orientation groups, respectively. Unadjusted and adjusted (demographics, depression, and health care access factors) weighted logistic regression models were developed. Results Obesity prevalence was lower in gay men relative to straight men with logistic regression modeling indicating gay men were significantly less likely to be obese, relative to their straight counterparts, in the unadjusted and adjusted models. In terms of prediabetes, rates were low across all sexual orientation groups with no significant differences observed. Yet bisexual men, relative to straight men, had higher rates of diabetes with significantly increased odds for the disease in both the unadjusted and adjusted models. Conclusion Findings indicate gay men have reduced risk for obesity while bisexual men may have increased diabetes burden. Across all male sexual orientation groups, prediabetes prevalence was low, suggesting the need for more aggressive prediabetes screening. Additional research is necessary to confirm the findings.
The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review
Authors: Ferreira Diana H , Boland Jason W , Phillips Jane L , Lam Lawrence , Currow David C 
Published: January 2018

Background: Driving cessation is associated with poor health-related outcomes. People with chronic diseases are often prescribed long-term opioid agonists that have the potential to impair driving. Studies evaluating the impact of opioids on driving-related psychomotor skills report contradictory results likely due to heterogeneous designs, assessment tools and study populations. A better understanding of the effects of regular therapeutic opioid agonists on driving can help to inform the balance between individual’s independence and community safety. Aim: To identify the literature assessing the impact of regular therapeutic opioid agonists on driving-related psychomotor skills for people with chronic pain or chronic breathlessness. Design: Systematic review reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis statement; PROSPERO Registration CRD42017055909. Data sources: Six electronic databases and grey literature were systematically searched up to January, 2017. Inclusion criteria were as follows: (1) empirical studies reporting data on driving simulation, on-the-road driving tasks or driving outcomes; (2) people with chronic pain or chronic breathlessness; and (3) taking regular therapeutic opioid agonists. Critical appraisal used the National Institutes of Health’s quality assessment tools. Results: From 3809 records screened, three studies matched the inclusion criteria. All reported data on people with chronic non-malignant pain. No significant impact of regular therapeutic opioid agonists on people’s driving-related psychomotor skills was reported. One study reported more intense pain significantly worsened driving performance. Conclusion: This systematic review does not identify impaired simulated driving performance when people take regular therapeutic opioid agonists for symptom control, although more prospective studies are needed.
Response Versus Nonresponse to Self-Regulatory Treatment Targets Is Not Discriminated by Personal Characteristics but Predicts Physical Activity, Eating Behavior, and Weight Changes in Women With Obesity
Authors: Annesi James J. 
Published: January 2018

Background Results of behavioral weight-loss treatments vary widely, with mostly unsuccessful outcomes beyond the short term. Women with obesity participating in a new cognitive-behavioral weight-loss treatment were assessed on their responses to psychological targets. Methods Groups of responders ( n = 43) and nonresponders ( n = 48) were established post hoc. Results Age, race/ethnicity, education, income, body composition, physical activity, and eating behaviors at baseline were not discriminated between responders and nonresponders. Over both 6 and 24 months, responders improved significantly more in physical activity and fruit/vegetable consumption but not sweets intake. Weight loss over 6 and 24 months was significantly greater for the responder group at 8.1% and 8.6% versus nonresponders at 4.7% and 3.8%, respectively. Self-regulation change significantly predicted all behavioral changes, with mood change improving the predictive strength for only sweets intake. Discussion Although further research is required to determine the etiology of, and to maximize, positive responses, findings suggested prospects for treatment improvements.
A Pedagogical Note on Multitier Pricing Scheme
Authors: Chang Winston W. , Chen Tai-Liang 
Published: January 2018

This note derives a new formula for determining a monopolist’s optimal multitier pricing scheme for any given number of tiers. It further characterizes Gabor’s ( Review of Economic Studies) two-tier pari passu marginal revenue function to the [Formula: see text]-tier case. By introducing the individual tier’s marginal revenue and the pari passu marginal revenue in a linear demand case, this note provides a perceptive graphical representation of the optimal pricing scheme, revealing that all tiers’ outputs are equal, the last tier’s price is always higher than the marginal cost, and an increase in the number of tiers increases social welfare. In a class of nonlinear demand functions, it shows that starting from the first tier, the tiers’ outputs are monotonically increasing (decreasing) if the demand function is strictly convex (concave). It also shows that the equal-tier-output property preserves in the linear demand case with the total output fixed as a constraint. JEL Classification: D01, D21, D42, L12, L21
Unbuckling of superelastic shape memory alloy columns
Authors: Watkins Ryan T , Shaw John A 
Published: January 2018

Our recent buckling experiments on superelastic shape memory alloy columns (initially straight rods and tubes) discovered that during axial shortening, certain specimens bent (buckled) at a critical compressive load and then, surprisingly, straightened (unbuckled) at a larger compressive load. This “buckling–unbuckling” phenomenon, defined here as the deviation from and then return to a straight configuration during monotonic loading, is not only an intriguing phenomenon (contrary to the post-buckling behavior of conventional materials) but also presents the possibility for novel applications. This work aims to provide a clearer understanding of when and why unbuckling occurs, presenting the experimental observations of this phenomenon and the stability analysis of a modified Shanley column model that captures the unbuckling behavior. Unbuckling behavior is shown to be a consequence of a secondary branch that deviates from the principal path at a low-load level (critical buckling load), but reattaches to the principal path at a higher load level (unbuckling load). The analysis shows that unbuckling behavior can only occur for certain combinations of column geometries and nonlinear (stiff–soft–stiff) material laws, that is, relatively stout columns with the right sequence of softening/stiffening to create the necessary restorative bending moment to reset the column to a straight configuration. The feasible space is defined by closed-form bounds on geometric and material parameters, along with a sensitivity analysis of these parameters on the amplitude of unbuckling.
The Practice and Science of Social Good: Emerging Paths to Positive Social Impact
Authors: Mor Barak Michàlle E. 
Published: January 2018

Purpose: To explore the practice and science of social good and identify avenues for producing research and evidence-based practice in this area. The main proposition of this paper is that social good has the potential to promote ideals that directly align with social work values, offer new alliances and innovative technologies for achieving them, and spark interest in macro practice. Method: To gain an understanding of social good, a three-pronged approach was used: (a) review of multidisciplinary academic literature; (b) review of web-based information; and (c) analysis of qualitative interviews with nine social good experts. Results: The combined data indicated three social good domains: diversity and inclusion, environmental justice and sustainability, and peace and collaboration. A proposed definition and conceptual model of social good has emerged from the data: (I) social good domains; (II) unconventional systems of change; and (III) innovative technologies and approaches. Conclusions: Social good can open up new opportunities for the social work profession, together with allied disciplines, to lead the development of evidence-based practices and educational programs aimed at promoting social justice. It can bring a fresh direction to social work, rooted in the profession’s bedrock values and befitting the entrepreneurial spirit, advances and technological innovations of the 21st century.
Impact of the Distance of Maxillary Advancement on Horizontal Relapse After Orthognathic Surgery
Authors: Fahradyan Artur , Wolfswinkel Erik M. , Clarke Noreen , Park Stephen , Tsuha Michaela , Urata Mark M. , Hammoudeh Jeffrey A. , Yamashita Dennis-Duke R. 
Published: January 2018

Background: The maxillary horizontal relapse following Le Fort I advancement has been estimated to be 10% to 50%. This retrospective review examines the direct association between the amounts of maxillary advancement and relapse. We hypothesize that the greater the advancement, the greater the relapse amount. Method: Patients with class III skeletal malocclusion underwent maxillary advancement with either a Le Fort I or a Le Fort I with simultaneous mandibular setback (bimaxillary surgery) from 2008 to 2015. Patients were assessed for a history of cleft lip or cleft palate. Patients with known syndromes were excluded. Cephalometric analysis was performed to compare surgical and postsurgical changes. Results: Of 136 patients, 47.1% were males and 61.8% had a history of cleft. The mean surgery age was 18.9 (13.8-23) years and 53.7% underwent a bimaxillary procedure. A representative subgroup of 35 patients had preoperative, immediate postoperative, and an average of 1-year postoperative lateral cephalograms taken. The mean maxillary advancement was 6.3 mm and the horizontal relapse was 1.8 mm, indicating a 28.6% relapse. A history of cleft and amount of maxillary advancement were directly correlated, whereas bone grafting of the maxillary osteotomy sites was inversely correlated with the amount of relapse ( P < .05). Conclusions: Our data suggest positive correlation between amount of maxillary advancement and horizontal relapse as well as a positive correlation between history of cleft and horizontal relapse. Bone grafting of the maxillary osteotomy sites has a protective effect on the relapse.