bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable preparation of nano monodispered ATP based color master batch and its application in PA6
Authors: He Bo , Ma Jianuo , Xiang Luobing , Wang Han , Wang Xi , Yi Chunwang 
Published: September 2024

AbstractAs a representative of dope‐dye, the color masterbatch method has been widely applied in modern dyeing processes, while it has difficulties in solving the dispersibility of inorganic pigments color master batch in the polymer matrix. In this work, attapulgite (ATP) was used as the adsorption carrier of inorganic pigments to prepare color‐dyed attapulgite (CD‐ATP). The selected environmentally friendly inorganic pigments were well adsorbed by ATP in KOH aqueous solution, and could stably be monodispersed in KOH aqueous solution for more than 168 h. Moreover, the KOH aqueous solution could be reused repeatedly, thereby, a sustainable method to prepare novel CD‐ATP was realized. By blending the as‐prepared CD‐ATP with polyamide‐6 (PA6), a series of dope‐dyed colorful PA6 composites was prepared. Scanning electron microscope (SEM) results indicated that the CD‐ATP was still monodispersed in the PA6 matrix, and endowed PA6 with a vivid color. Further studies show that the adding of CD‐ATP had little influence on the properties of PA6, but significantly reduced the water adsorption. This novel color‐dyed ATP has potential implications in making paper‐making blankets and is highly expected to have more extensive applications in many fields of life.
Catechin as a functional additive in electrospun PCL/gelatin/nHA nanocomposite fibers for tissue engineering applications
Authors: Mohammed Rubiya , Chacko Sobi K. , Balakrishnan Raneesh , Thomas Nebu George , Binsi P. K. , Muhamed Ashraf P. , Krishnan Nikhil , Anil Sukumaran 
Published: September 2024

AbstractThe promise of polymeric nanocomposite fibers in the biomedical field is well‐documented due to their adjustable properties and versatility. Electrospun fiber mats, which mimic the extracellular matrix, are particularly noted for their potential in tissue regeneration and repair. In this study, we investigate the role of catechin, a flavonoid, in enhancing cellular response to electrospun nanocomposite fibers of polycaprolactone (PCL), gelatin, and nanohydroxyapatite (nHA). Nanocomposite fibers were fabricated with varying concentrations of catechin and comprehensive analyses of the composite fibers were performed to evaluate their structural and chemical properties. In vitro, assays were performed to examine cell viability and ascertain the influence of catechin on cellular responses to these nanocomposite fibers. Simultaneously, in vivo studies assessed tissue responses to these materials. The findings revealed that incorporating catechin into PCL/gelatin/nHA nanocomposite fibers improved cellular responses in vitro as demonstrated by enhanced cell viability. Furthermore, in vivo investigations displayed positive tissue responses with these fibers, indicating their capacity to enhance cell growth and accelerate tissue regeneration. This study elucidates the potential of catechin as an integral component in designing polymeric nanocomposite fibers, potentially broadening the scope of their biomedical applications.
A 3D hydrogel scaffold with adjustable interlayer spacing for the formation of compact myocardial tissue
Authors: Yang Jianhui , Xu Feng , Jin Hang , Zhou Zhuomin , Wu Huiquan , Zhang Wangzihan , Xue Mingcheng , Qiu Bin , Gao Qiang , Lin Bin , Chen Songyue , Sun Daoheng 
Published: September 2024

AbstractThe design and optimization of three‐dimensional tissue scaffolds have presented a persistent challenge for myocardial tissue engineering. While current scaffolds have made strides in mimicking in vivo three‐dimensional environments, the presence of interlayer spacing has limited the formation of densely packed tissue, impeding cell‐to‐cell connections. We proposed a novel dynamic three‐dimensional myocardial tissue engineering scaffold with adjustable interlayer spacing, aiming to improve the uniformity of cell distribution and facilitate effective cell communication. The device was composed of hydrogel scaffolds that were fabricated with poly (ethylene glycol) diacrylate (PEGDA) and flexible elastomer actuators that composed of polyurethane acrylate (PUA). Human induced pluripotent stem cell‐derived cardiomyocytes mixed with gelatin methacryloyl (GelMA) were seeded onto the multi‐layered scaffold with initial spacing of 100–500 μm. Experimental results indicated the seeding efficiency was maximized at an initial spacing of 400 μm. By decreasing the interlayer spacing, cell growth morphology and gap junction protein expression was improved. This work demonstrated the effect of interlayer spacing modulation to the tissue density and provided a potential approach for cultivation of compact and multi‐layered myocardial tissue.
Influence of polar‐modified ESBO on the thermal and mechanical properties of FKM/EPDM rubber blends
Authors: Du Faxin , Liu Gen , Yao Zhangjun , Zhou Shengrong , Wang Qiuhong , Yang Chengqiang , Lu Qian , He Pan , Cao Jiaxuan , Chen Honglin , Wei Yujun , Han Rui , Zhang Shuai , Li Guang‐Zhao 
Published: September 2024

AbstractRenowned for its oil, heat, and chemical resistance, fluoroelastomer rubber (FKM) also presents notable drawbacks, such as inferior low‐temperature performance. In this study, 2,2‐trifluoroethylamine (TF) and 2,4‐difluorobenzylamine (DF) were grafted onto epoxidized soybean oil (ESBO) to generate two innovative plasticizers: ESBO‐TF and ESBO‐DF that they were specifically designed to augment the low‐temperature performance of FKM. A thorough investigation into the effects of ESBO‐TF/DF on FKM/EPDM blends' properties was conducted. The study demonstrated that the integration of ESBO‐TF and ESBO‐DF enhanced the vital properties of the FKM/EPDM blends, including elongation at break, tear strength, and, significantly, low‐temperature performance. There was a noticeable decrease in the glass transition temperature (Tg), dropping by 3.54 and 2.95°C with the incorporation of 10 phr ESBO‐TF and ESBO‐DF, respectively. These respective plasticizers showed positive effects on the plasticization and compatibilization of the FKM/EPDM blends, thus proposing a novel methodology for developing new plasticizers for FKM and related blends.
Polydopamine‐modified black phosphorus/microcapsule composite material used to enhance the solar thermal conversion and self‐healing performance of SBS modified asphalt
Authors: Ren Denghui , Jiang Hao , Fan Shencheng , Song Liu , Luo Yating , Lai Fang , Pei Ruinan , Yang Qingzhao , Li Jing 
Published: September 2024

AbstractThis study developed UV‐responsive microcapsules to enhance the self‐healing properties of asphalt, addressing the limitations of low survival rates and single‐release mechanisms in current encapsulated rejuvenators. The microcapsules, featuring a urea‐formaldehyde shell embedded with polydopamine‐coated black phosphorus nanosheets (BP/DA) and microalgae bio‐oil as the core, can convert solar energy into thermal energy, promoting proactive self‐healing in asphalt materials. BP/DA expands the microcapsules' light absorption range, enhancing their photothermal conversion efficiency. When incorporated into styrene‐butadiene‐styrene (SBS)‐modified asphalt at a 1.5% dosage, the microcapsules (BP/DA/MC) improved the mechanical properties: ductility increased by 13.7%, softening point rose by 2%, and penetration decreased by 3.3%. The storage modulus (G′) at 46 and 64°C increased by 35.9% and 24.3%, respectively, compared to SBS asphalt. Additionally, the ductility self‐healing rate of BP/DA/MC/SBS asphalt improved by 209.7%, with a healing index (HI) of 78.16%. The microcapsules also demonstrated excellent photothermal conversion, increasing the asphalt's temperature by 22.6% under identical lighting conditions. This research offers a new method for developing intelligent self‐healing asphalt with multi‐mechanism activation, providing theoretical support for future third‐generation microcapsule‐based asphalt with remote‐controlled release and activation response.
A modified microscale viscosity model of polymer melts and experimental verification
Authors: Zhang Jiakun , Wang Minjie , Li Hongxia 
Published: September 2024

AbstractDuring the micro‐molding of polymer melts, ensuring the viscosity models' accuracy was essential. Existing models had neglected the temperature dependence of microscale factor, rendering them unsuitable for materials with varying temperature sensitivities. This research employed a twin‐bore capillary rheometer and dies of distinct characteristic dimensions as the experimental setup to investigate the viscosity variations across four materials exhibiting diverse temperature sensitivities. A modified MCA viscosity model was established by integrating a microscale factor that accounted for both dimension and temperature dependence into the macroscopic Carreau viscosity model. The traditional MCAc model, which ignored the microscale factor's temperature dependence, offered a comparative reference. These models were subsequently applied to evaluate the influence of coupling effects between viscosity and viscous dissipation on melt temperature, with results compared to experimental data. The results indicated that the MCA model's viscosity forecasts were in closer accord with experimental measurements, maintaining an accuracy within a 16% margin. The models' application to temperature calculations under varying inlet velocities and temperatures confirmed that the MCA model's predictions of the temperature increase along the flow direction were more congruent with experimental outcomes, underscoring the critical importance of incorporating both dimension and temperature dependence when establish microscale viscosity models.
Novel benzothiazole/benzothiazole thiazolidine‐2,4‐dione derivatives as potential FOXM1 inhibitors: In silico, synthesis, and in vitro studies
Authors: Abusharkh Khaled A. N. , Comert Onder Ferah , Çınar Venhar , Onder Alper , Sıkık Merve , Hamurcu Zuhal , Ozpolat Bulent , Ay Mehmet 
Published: September 2024

AbstractThe oncogenic transcription factor FOXM1 overexpressed in breast and other solid cancers, is a key driver of tumor growth and progression through complex interactions, making it an attractive molecular target for the development of targeted therapies. Despite the availability of small‐molecule inhibitors, their limited specificity, potency, and efficacy hinder clinical translation. To identify effective FOXM1 inhibitors, we synthesized novel benzothiazole derivatives (KC10–KC13) and benzothiazole hybrids with thiazolidine‐2,4‐dione (KC21–KC36). These compounds were evaluated for FOXM1 inhibition. Molecular docking and molecular dynamics simulation analysis revealed their binding patterns and affinities for the FOXM1‐DNA binding domain. The interactions with key amino acids such as Asn283, His287, and Arg286, crucial for FOXM1 inhibition, have been determined with the synthesized compounds. Additionally, the molecular modeling study indicated that KC12, KC21, and KC30 aligned structurally and interacted similarly to the reference compound FDI‐6. In vitro studies with the MDA‐MB‐231 breast cancer cell line demonstrated that KC12, KC21, and KC30 significantly inhibited FOXM1, showing greater potency than FDI‐6, with IC50 values of 6.13, 10.77, and 12.86 µM, respectively, versus 20.79 µM for FDI‐6. Our findings suggest that KC12, KC21, and KC30 exhibit strong activity as FOXM1 inhibitors and may be suitable for in vivo animal studies.
Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis
Authors: Hiramoto Kazuoto , Saito Shuntaro , Hanaoka Hironari , Kikuchi Jun , Fukui Hiroyuki , Hashiguchi Akinori , Suzuki Katsuya , Takeuchi Tsutomu , Kaneko Yuko 
Published: September 2024

ObjectiveThere is a pressing need to understand the pathogenesis of histologic findings and identify the biomarkers for predicting the histologic severity in lupus nephritis (LN). This study aimed to identify the pathogenic signal pathway and elucidate urinary biomarkers for predicting the presence or severity of histologic findings in LN.MethodsUrine samples from patients with biopsy‐proven active LN were screened for 1,305 proteins using an aptamer‐based proteomic assay. The diversity and expansion of individual renal histologic features in LN were quantified to identify the urinary proteins associated with the histologic findings found in each score. Candidate urinary proteins were validated in a validation cohort. Immunohistochemical staining of the renal tissues was performed to clarify the localization of the candidate proteins.ResultsCluster analysis extracted five histologic subgroups according to their correlations with each histologic finding in LN. Protein groups that correlated with each histologic subgroup revealed a distinct pathogenesis in LN using pathway analyses. Enzyme‐linked immunosorbent assay validation revealed that urinary calgranulin B (S100A9), monocyte chemotactic protein 1 (MCP‐1), and insulin‐like growth factor binding protein 5 (IGFBP‐5) levels could specifically predict the presence and severity of active glomerular lesions, interstitial inflammation, and interstitial fibrosis, respectively. Immunohistochemical staining revealed the localization of these proteins in each lesion.ConclusionRenal histologic findings may reflect the different pathogeneses involved in each lesion, and estimating the urinary calgranulin B, MCP‐1, and IGFBP‐5 levels may be useful in predicting the presence and severity of histologic findings in LN.
Direct Recycling of LixNi0.5Mn0.3Co0.2O2 from Production Scrap and End‐Of‐Life Batteries, Using Solid‐State Relithiation
Authors: Sita Lucas Evangelista , Sommerville Roberto , Alsofi Giar , Lima da Silva Wilgner , Gastol Dominika , Scarminio Jair , Kendrick Emma 
Published: September 2024

AbstractDirect recycling of Li‐ion battery cathodes offers a sustainable and potentially cost‐effective alternative to conventional methods, often involving complex chemical processes and significant material losses. This study focuses on the relithiation of cathode materials from quality control reject (QCR) and end‐of‐life (EoL) Li‐ion cells to restore their physical structure, morphology, and electrochemical performance. Two NMC532/graphite pouch cells from the same manufacturer were studied. QCR cells, stored under ambient conditions, experienced corrosion and degradation before recycling, while EoL cells were cycled to the end of life. The cells were disassembled, and the cathode materials were delaminated using NaOH solution, then relithiated with LiOH at 700 °C for 15 hours in the air. Extensive characterization analyzed elemental composition, structural properties, thermal stability, and particle size distribution. Results indicated that relithiation successfully restored lithium content and improved the structural ordering and morphology of the cathode materials. The electrochemical performance of the relithiated cathodes exhibited good stability over 100 charge‐discharge cycles. The relithiated QCR samples achieved a capacity of 155.57 mAh g−1, while EoL samples reached 152.53 mAh g−1, comparable to pristine materials. This study highlights relithiation's potential to extend the lifecycle of Li‐ion cathodes, contributing to a more sustainable circular economy for battery materials.
Bulk Alloy Anodes for Sodium‐Ion Batteries
Authors: Wang Xiaohan , Zhao Xiaoying , Wang Liubin 
Published: September 2024

AbstractSodium‐ion batteries (SIBs) are considered a promising candidate for next‐generation energy storage systems due to the abundance of available sodium resources. The practical application of SIBs critically depends on developing durable electrode materials with high capacity and long lifespan, particularly when it comes to finding suitable anode materials. Alloy‐type anodes are appealing for their high capacities owing to the multiple electron transfer alloying reaction mechanism, making them ideal for high‐energy‐density SIBs. However, the huge volume change during charge/discharge process can cause the active material pulverization to detach from the current collector, leading to poor cycling performance, especially for bulk alloy anodes. Despite this challenge, recent progress in bulk or micro‐sized alloy anodes for SIBs have shown promise. This review highlights the up‐to‐date advancements and research on bulk alloy‐based anode materials for SIBs, including synthetic strategies and electrochemical performance. The crucial role of bulk alloy anodes in advancing SIB technology is discussed, along with a summary of research on bulk alloy‐type anodes and their compounds for sodium storage. Strategies to improve the electrochemical performance of bulk alloy‐based anode materials are also explored. Additionally, the potential of multi‐component alloys and high‐entropy alloys as future research directions for alloy‐based anodes is proposed.
Decreasing self‐injury in a child with multiple disabilities: A practitioner's demonstration
Authors: Laureano Brianna , Bajracharya Rajen , Chesbrough Emily A. , Falligant John Michael 
Published: September 2024

AbstractSelf‐injurious behavior is thought to be the product of interactions between deficits related to a primary disability (e.g., limited communication repertoires and adaptive skills) and learning experiences that reinforce problem behavior (e.g., consoling the child, terminating non‐preferred activities, etc.). For these cases, functional communication training (FCT) may be prescribed to decrease challenging behavior and increase the client's communicative repertoire. However, FCT procedures for individuals with multiple physical impairments may require considerable individualization and modifications. Unfortunately, the existing body of research related to the assessment and treatment of behavior of individuals with motor, visual, or other impairments is relatively limited. The purpose of this report is to demonstrate how practitioners can modify assessment and treatment procedures to decrease challenging behavior and promote independence when working with individuals with multiple impairments. We provide an example of effective skill acquisition and behavior reduction interventions for a young girl, Ava, presenting with multiple disabilities—including visual, hearing, and motor impairments. Consistent with the habilitative aims of applied behavior analysis, the intervention was effective at decreasing Ava's challenging behavior and increasing her independent communication and adaptive behavior.
EPR spectroscopy: A versatile tool for exploring transition metal complexes in organometallic and bioinorganic chemistry
Authors: Ju Minyoung , Kim Jin , Shin Jeongcheol 
Published: September 2024

AbstractParamagnetic molecules, such as main‐group radicals and transition metal complexes, play crucial roles in catalytic and enzymatic reactions in organometallic and bioinorganic chemistry. Electron paramagnetic resonance (EPR) spectroscopy emerges as a powerful tool for probing the intricate electronic and geometric structures of these molecules. The application of EPR spectroscopy spans a wide spectrum of chemical entities, from simple radicals to transition metal complexes, metalloproteins, and metal clusters, emphasizing its versatility across various fields of chemistry. This review introduces the EPR spectra of transition metal complexes, offering a comprehensive theoretical foundation along with illustrative examples from both bioinorganic and organometallic chemistry. These examples highlight the effectiveness of EPR spectroscopy in characterizing transition metal complexes, reinforcing our understanding of their structure and reactivity.
Anti‐LSSDS pharmacological components identification of YuHuangLian based on the combination of spectrum–effect analysis and network pharmacology as well as molecular docking
Authors: Xu Beilei , Chen Shengnan , Liu Jingjing , Wu Di , Sun Wenbin , Liu Shusen , Hu Yang , Wang Hao , Wang Jinhong , Yang Bo , Li Wenlan , Ma Shuangcheng 
Published: September 2024

AbstractThis research aimed to investigate the pharmacological components for liver stagnation and spleen deficiency syndrome (LSSDS) of Evodia rutaecarpa (also called Yu HuangLian [YHL]) by exploring the spectrum–effect relationship between fingerprints and pharmacological actions. The fingerprints of 17 batches of YHL with different preparation conditions according to Box–Behnken Design were generated and analyzed to identify the common peaks by HPLC and FT‐IR. Vasoactive intestinal peptide (vip), substance P, and 5‐HT levels in colon sample were measured by ELISA. Gray degree correlation and orthogonal partial least squares were employed to explore the correlation degree between components and pharmacologic activity. The presumed pharmacological components were further confirmed by network pharmacology, molecular docking, and qRT‐PCR. The columbamine, jatrorrhizine, coptisine, berberine, rutecarpine, and evodiamine of the 14 common peaks in HPLC fingerprints were significantly correlated with the pharmacological indexes. Similarly, there was a strong correlation with ‐OH, δNC‐H, and νC‐O‐C of the 10 common peaks in FT‐IR fingerprints. PTGS2 and CHRM3 were the main targets intervening LSSDS, and the presumed pharmacological components could markedly increase the expression of CHRM3 and obviously reduce the expression of PTGS2 compared with the model group.
Effect of Motor Interference Therapy on Distress Related to Traumatic Memories: A Randomized, Double‐Blind, Controlled Feasibility Trial
Authors: Morales‐Rivero Alonso , Crail‐Meléndez Daniel , Reyes‐Santos Lorena , Bisanz Erik , Bisanz Jeffrey , Ruiz‐Chow Angel , Chavarria‐Medina Monica Maritza 
Published: September 2024

ABSTRACTIntroductionTraumatic memories (TM) are a core feature of stress‐related disorders, including posttraumatic stress disorder (PTSD). Treatment is often difficult, and specific pharmacological interventions are lacking. We present a novel non‐pharmacological intervention called motor interference therapy (MIT) as a promising alternative for these symptoms.AimsTo determine the feasibility of MIT, a brief, audio‐delivered, and non‐pharmacological intervention that uses cognitive and motor tasks to treat TM.MethodsWe designed a randomized, double‐blind trial. Twenty‐eight participants from an outpatient clinic with at least one TM were included to receive either MIT or progressive muscle relaxation (PMR). Spanish versions of the PTSD symptom severity scale (EGS), visual analog scale for TM (TM–VAS), and quality of life (EQ–VAS) were applied prior to intervention, 1 week, and 1 month following intervention.ResultsMean scores on all measures improved from baseline to posttest for both groups. MIT participants showed significantly more positive scores at 1 week and 1 month (TM–VAS baseline: 9.8 ± 0.4; immediate: 6.0 ± 2.0; 1 week: 3.8 ± 3.1 [d = 1.57]; 1 month 2.9 ± 2.8 [d = 1.93]) than PMR participants on measures of distress due to TM, trauma re‐experiencing, anxiety, and a composite measure of PTSD.ConclusionMIT is a simple, effective, and easy‐to‐use tool for treating TM and other stress‐related symptoms. It requires relatively few resources and could be adapted to many contexts. The results provide proof‐of‐principle support for conducting future research with larger cohorts and controls to improve clinical effectiveness and research on brief interventions.Trial RegistrationClinicalTrials.gov Identifier: NCT03627078