bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroinduced Intercalation of Tetraalkylammonium Ions at the Interface of Graphene Grown on Copper, Platinum, and Iridium
Authors: Salmi Zakaria , Koefoed Line , Jensen Bjarke B. E. , Čabo Antonija Grubišić , Hofmann Philip , Pedersen Steen U. , Daasbjerg Kim 
Published: October 2016

AbstractElectrochemically driven intercalation of tetraalkylammonium ions can facilitate the delamination of graphene films fabricated by chemical vapour deposition (CVD) from their supporting metal catalyst and, hereby, ease the transfer of the graphene to other substrates. The electroinduced intercalation is performed by applying a negative potential to the metal/graphene cathode, while immersed into an electrolyte solution of the tetraalkylammonium ions in acetonitrile. As part of the double layer the cations intercalate the interface between the metal and the graphene, which increases the interfacial distance as well as weakens the interaction with and the screening effect of the metal. The individual stages of the intercalation and delamination were studied for CVD grown graphene on Cu, Pt, and Ir. Experimentally, the intercalation is seen to give a significant increase in the intensity of the recorded Raman spectra and most of the compressive strain in graphene is released. The electroinduced intercalation does not increase the defect or doping levels of graphene. Also, it is shown that easy transfer of the intercalated graphene to Si/SiO2 can be accomplished.
Interface between an Au(111) Surface and an Ionic Liquid: The Influence of Water on the Double‐Layer Capacitance
Authors: Friedl Jochen , Markovits Iulius I. E. , Herpich Max , Feng Guang , Kornyshev Alexei A. , Stimming Ulrich 
Published: October 2016

AbstractThe presence of water in room‐temperature ionic liquids (RTILs) can have a strong effect on their properties. In particular, water adsorption at electrodes can reduce the electrochemical potential window of the system. It is, thus, important to understand where water will be present depending on the electrode potential, the type of ionic liquid, and the electrode material. We investigate the influence of water on RTILs by measuring the potential‐dependent double‐layer capacitance of various water–RTIL mixtures. The resulting capacitance versus potential curves are reproduced employing mean‐field theory calculations. From the parameters used to obtain the best agreement between experimental and theoretical curves, some properties of the RTILs can be deducted, such as a stronger interaction of water with RTIL anions than cations and an agglomeration of water at potentials positive or negative of the potential of zero charge.
ChemInform Abstract: NOUF6 Revisited: A Comprehensive Study of a Hexafluoridouranate(V) Salt.
Authors: Scheibe Benjamin , Lippert Sina , Rudel Stefan S. , Buchner Magnus R. , Burghaus Olaf , Pietzonka Clemens , Koch Martin , Karttunen Antti J. , Kraus Florian 
Published: October 2016

AbstractIn view of the separation of U isotopes in nuclear fuel element reprocessing, single crystals of NOUF6 are obtained by direct reaction of NO with UF6 in anhydrous HF (FEP reaction tube, ‐78 °C) after pumping off excess HF and UF6.
ChemInform Abstract: Palladium‐Catalyzed C—H Activation and Cyclization of Anilides with 2‐Iodoacetates and 2‐Iodobenzoates: An Efficient Method Toward Oxindoles and Phenanthridones.
Authors: Gandeepan Parthasarathy , Rajamalli Pachaiyappan , Cheng Chien‐Hong 
Published: October 2016

AbstractIn the case of meta‐substituted anilides, e.
ChemInform Abstract: Rh‐Catalyzed N—O Bond Cleavage of Anthranil: A C—H Amination Reagent for Simultaneous Incorporation of Amine and a Functional Group.
Authors: Zou Miancheng , Liu Jianzhong , Tang Conghui , Jiao Ning 
Published: October 2016

AbstractAnthranils are employed as a new type of C—H amination reagent.
ChemInform Abstract: Metal‐Free Cross‐Dehydrogenative Coupling of Aryl Aldehydes to Give Symmetrical Carboxylic Anhydrides Promoted by the TBHP/nBu4PBr System.
Authors: Adib Mehdi , Pashazadeh Rahim , Rajai‐Daryasarei Saideh , Mirzaei Peiman , Jamal Addin Gohari Seyed 
Published: October 2016

AbstractWhereas aromatic aldehydes bearing electron‐donating substituents afford the corresponding anhydrides in good yields, derivatives with electron‐withdrawing substituents, e.g. (Ig,h), fail to give the transformation.
ChemInform Abstract: Copper‐Mediated [3 + 2] Oxidative Cyclization Reaction of N‐Tosylhydrazones and β‐Ketoesters: Synthesis of 2,3,5‐Trisubstituted Furans.
Authors: Huang Yubing , Li Xianwei , Yu Yue , Zhu Chuanle , Wu Wanqing , Jiang Huanfeng 
Published: October 2016

AbstractFor the first time, N‐tosylhydrazones are utilized as two‐carbon building block in a copper‐mediated [3 + 2] oxidative cyclization reaction affording trisubstituted furans.
ChemInform Abstract: N‐Methylniphatyne A, a New 3‐Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.
Authors: Arai Masayoshi , Kamiya Kentaro , Shin Dayoung , Matsumoto Hirokazu , Hisa Tomoya , Setiawan Andi , Kotoku Naoyuki , Kobayashi Motomasa 
Published: October 2016

AbstractThe cytotoxicity of (I) is examined.
Einflüsse unterschiedlicher verfahrenstechnischer Parameter auf die Ultrafiltration des Bieres
Authors: Bilge Deniz , Pahl Roland 
Published: October 2016

AbstractDer Schaum des Bieres ist ein wichtiges Qualitätsmerkmal, das durch brautechnologische Maßnahmen nur in einem gewissen Maß positiv beeinflusst werden kann. Die Anreicherung schaumpositiver Proteine durch Ultrafiltration könnte hier eine verfahrenstechnische Lösung bieten. Dieser Artikel beschreibt die Einflüsse ausgewählter Prozessparameter, wie Druck, Temperatur und Porenweite, auf den Permeatfluss von Bier und die chemisch‐physikalischen Eigenschaften der Retentate. Für die erhöhten Trübungen und die geringe Trübungsstabilität der Retentate wurden technologische Lösungen gefunden.
T‐cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance
Authors: Dasen Boris , Vlajnic Tatjana , Mengus Chantal , Ruiz Christian , Bubendorf Lukas , Spagnoli Giulio , Wyler Stephen , Erne Paul , Resink Thérèse J , Philippova Maria 
Published: October 2016

AbstractProstate cancer represents the second leading cause of cancer‐related death in men. T‐cadherin (CDH13) is an atypical GPI‐anchored member of the cadherin family of adhesion molecules. Its gene was reported to be downregulated in a small series of prostate tumours. T‐cadherin protein expression/localisation in prostate tissue has never been investigated. The purpose of our study was to analyse CDH13 gene and protein levels in large sets of healthy and cancer prostate tissue specimens and evaluate CDH13 effects on the sensitivity of prostate cancer cells to chemotherapy. Analysis of CDH13 gene expression in the TCGA RNAseq dataset for prostate adenocarcinoma (N = 550) and in tissue samples (N = 101) by qPCR revealed weak positive correlation with the Gleason score in cancer and no difference between benign and malignant specimens. Immunohistochemical analysis of tissue sections (N = 12) and microarrays (N = 128 specimens) demonstrated the presence of CDH13 on the apical surface and at intercellular contacts of cytokeratin 8‐positive luminal cells and cells double‐positive for cytokeratin 8 and basal marker p63. T‐cadherin protein expression was markedly upregulated in cancer as compared to benign prostate hyperplasia, the increase being more prominent in organ‐confined than in advanced hormone‐resistant tumours, and correlated negatively with the Gleason pattern. T‐cadherin protein level correlated strongly with cytokeratin 8 and with an abnormal diffuse/membrane localisation pattern of p63. Ectopic expression of CDH13 in metastatic prostate cancer cell line DU145 reduced cell growth in the presence of doxorubicin. We conclude that CDH13 protein, but not its gene expression, is strongly upregulated in early prostate cancer, correlates with changes in luminal/basal differentiation and p63 localisation, and promotes sensitivity of cancer cells to doxorubicin. These data identify CDH13 as a novel molecule relevant for prostate cancer progression and response to therapy.
Repeated adjuvant anti‐CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long‐term efficacy results of a prospective phase 2 study
Authors: Sahlmann Carsten‐O. , Homayounfar Kia , Niessner Martin , Dyczkowski Jerzy , Conradi Lena‐Christin , Braulke Friederike , Meller Birgit , Beißbarth Tim , Ghadimi B. Michael , Meller Johannes , Goldenberg David M. , Liersch Torsten 
Published: October 2016

BACKGROUNDIn previous work, a single administration of anticarcinoembryonic antigen (anti‐CEA) 131I‐labetuzumab radioimmunotherapy (RIT) after complete resection of colorectal liver metastases was well tolerated and significantly improved survival compared with controls. In the current phase 2 trial, the authors studied repeated RIT in the same setting, examining safety, feasibility, and efficacy.METHODSSixty‐three patients (median age, 64.5 years) received RIT at 40 to 50 millicuries/m2 per dose. Before the receipt of RIT, restaging was performed with computed tomography/magnetic resonance imaging and 18F‐fluorodeoxyglucose–positron emission to confirm that patients were “truly adjuvant.” Patients who had elevated serum CEA levels or radiographically inconclusive new lesions were classified as “possibly nonadjuvant,” but they also received RIT. Time to progression (TTP), overall survival (OS), and cause‐specific survival (CSS) were calculated. The median follow‐up was 54 months.RESULTSAfter the first course of RIT, 14 of 63 patients experienced National Cancer Institute Common Toxicity Criteria grade 4 hematotoxicity; 19 patients did not receive the second course of RIT because of impaired performance status (N = 5) or relapse (N = 14). After the second course of RIT, 9 of 44 patients experienced National Cancer Institute Common Toxicity Criteria grade 4 hematotoxicity. Five patients developed myelodysplastic syndrome (MDS) from 22 to 55 months after their last RIT. The median TTP, OS, and CSS for all patients were 16, 55, and 60 months, respectively. The “truly adjuvant” patients (N = 39) had an improved median TTP (not reached vs 6.1 months; hazard ratio, 0.12; P < .001), OS (75.6 vs 33.4 months; hazard ratio, 0.44; P = .014), and CSS (not reached vs 41.4 months; hazard ratio,0.42; P = .014) compared with “possibly nonadjuvant” patients (N = 24).CONCLUSIONSRepeated RIT with 131I‐labetuzumab is feasible but is associated with hematotoxicity. Survival is very encouraging, especially for “truly adjuvant” patients. However, the maximum safe dose of 131I‐labetuzumab is a single administration of 50 millicuries/m2. Cancer 2017;123:638–649. © 2016 American Cancer Society.
Production of RbCs Molecules in the Rovibronic Ground State via Short‐Range Photoassociation to the 2 1Π1, 2 3Π1, and 3 3Σ States
Authors: Shimasaki Toshihiko , Kim Jin‐Tae , DeMille David 
Published: October 2016

AbstractWe report the production of ultracold 85Rb133Cs molecules in their rovibronic ground state X 1Σ+ (v=0; J=0), by short‐range photoassociation (PA) to the 2 1Π1, 2 3Π1, and 3 3Σ
states. In the PA frequency range from 11650 to 12150 cm−1 (corresponding to energy levels 15500–16000 cm−1 above the bottom of the X potential), we have observed 40 sets of new PA lines. For selected PA states, we investigate vibrational branching, rotational branching, and saturation behavior. Among these 40 new PA lines, the 3 3Σ
(v=3) state has the highest molecule production rate of 2 x 103 molecules s−1 into the rovibronic ground state.
Interactive effects of waterlogging and atmospheric CO2 concentration on gas exchange, growth and functional traits of Australian riparian tree seedlings
Authors: Lawson James R. , Fryirs Kirstie A. , Leishman Michelle R. 
Published: October 2016

AbstractThe ability to survive and thrive in repeatedly waterlogged soils is characteristic of plants adapted to riparian habitats. Rising atmospheric CO2 has the potential to fundamentally alter plant responses to waterlogging by altering gas exchange rates and stoichiometry, modifying growth, and shifting resource‐economic trade‐offs to favor different ecological strategies. While plant responses to waterlogging and elevated CO2 individually are relatively well characterized, few studies have asked how the effects of waterlogging might be mediated by atmospheric CO2 concentration.We investigated interactive effects of elevated (550 ppm) atmospheric CO2 and waterlogging on gas exchange, biomass accumulation and allocation, and functional traits for juveniles of three woody riparian tree species. In particular, we were interested in whether elevated CO2 mitigated growth reduction under waterlogging, and whether this response was sustained following a refractory “recovery” period during which soils were re‐aerated.We found species‐specific effects of atmospheric CO2 concentration and waterlogging status on growth, gas exchange, and functional traits between species, and no evidence for a general effect of elevated CO2 in mediating plant responses to flooding. For one specie, Casuarina cunninghamiana, elevated CO2 substantially increased growth, but this effect was entirely removed by waterlogging, and there was no recovery following a refractory period.Differential responses to combined waterlogging and elevated CO2 among species may result in compositional changes to riparian plant communities and associated changes in ecosystem functioning.
Winding Method to Reduce Vibration and Loss Caused by Fractional Slot of Synchronous Machine
Authors: HIRAMATSU DAISUKE , TSUJIKAWA KAZUMA , UEDA TAKASHI , FUJITA MASAFUMI , ISHIZUKA HIROAKI , OKUBO MASASHI , HACHIYA HIDEYUKI , MORI JUNJI , NOZAKI DAI , IWASHITA DAISUKE , TOKUMASU TADASHI 
Published: October 2016

SUMMARYFractional‐slot windings are widely used in rotating machines in order to improve the output voltage waveform, increase the design flexibility, and gain many other advantages. However, fractional‐slot windings are known to produce different harmonic components such as an even order and/or fractional number of space flux harmonics compared to integral‐slot windings. These harmonics may increase stray losses and cause stator core vibration. This paper describes an analysis of space flux harmonics and proposes new winding methods such as “novel interspersed windings” to reduce these harmonic components. The proposed winding methods were verified by numerical analysis and model tests.
Is autopsy tissue a valid control for epilepsy surgery tissue in microRNA studies?
Authors: Roncon Paolo , Zucchini Silvia , Ferracin Manuela , Marucci Gianluca , Giulioni Marco , Michelucci Roberto , Rubboli Guido , Simonato Michele 
Published: October 2016

SummaryMicroRNAs (miRNAs) are differentially expressed in the brain under pathologic conditions and may therefore represent both therapeutic targets and diagnostic or prognostic biomarkers for neurologic diseases, including epilepsy. In fact, miRNA expression profiles have been investigated in the hippocampi of patients with epilepsy in comparison with control, nonepileptic cases. Unfortunately, the interpretation of these data is difficult because surgically resected epileptic tissue is generally compared with control tissue obtained from autopsies. To challenge the validity of this approach, we performed an miRNA microarray on the laser microdissected granule cell layer of the human hippocampus obtained from surgical samples of patients with epilepsy, autoptic nonepileptic controls, and patients with autoptic epilepsy, using the latter as internal control. Unfortunately, it is extremely difficult to collect autopsy material from documented epilepsy individuals who died of non–epilepsy‐related causes—we found only two such cases. However, hierarchical clustering of all samples showed that those obtained from autopsies of patients with epilepsy segregated with the other autoptic samples (controls) and not with the bioptic tissues from the surgery patients, suggesting that the origin of the tissue (surgery or autopsy) may be prevalent over the underlying pathology (epilepsy or not epilepsy). Even taking into account the limitations due to the small number of cases, this observation arises concerns on the use of autopsy tissue as control for this kind of studies.
Long‐Term Landscape Changes in the Lake Tana Basin as Evidenced by Delta Development and Floodplain Aggradation in Ethiopia
Authors: Abate Mengiste , Nyssen Jan , Moges Michael M. , Enku Temesgen , Zimale Fasikaw A. , Tilahun Seifu A. , Adgo Enyew , Steenhuis Tammo S. 
Published: October 2016

AbstractLandscape response to drivers of change is more visible and noticeable in deltas and floodplains than in upstream. Here, we address the changes of Lake Tana basin by investigating the delta development of Gumara River and sediment deposition in the Fogera floodplain over a 58‐year period when agricultural land expanded, agriculture intensified, and flooding of the alluvial plain became more frequent. Old maps show that delta formation before the 1950s was minimal, indicating that the sediment contributed by the rivers to the lake was small. However, during the last 58 years, the delta has expanded continuously. When considering the same lake level (2·68 m) from 1984 to 2014, the delta has expanded an average of 5 ha annually, and by considering different lake levels and corresponding delta areas, the delta increased in height an average of 3 cm annually. While the growth of the delta was approximately linear, the sediment concentration in the river doubled in the last 30 years, indicating more efficient sediment trapping in the floodplain as a result of higher lake levels, rising river beds, and farmers intervening with the course of the river near the shore. Unless effective river restoration and catchment‐based treatment measures are put in place, the capacity of the rivers will further reduce and aggravate the flooding of the floodplain, causing more sediment deposition in the river channel and on the floodplain. Copyright © 2016 John Wiley & Sons, Ltd.
Use of 5‐Fluorouracil Loaded Micelles and Cisplatin in Thermosensitive Chitosan Hydrogel as an Efficient Therapy against Colorectal Peritoneal Carcinomatosis
Authors: Yun Qin , Wang Si Song , Xu Shan , Yang Jin Ping , Fan Juan , Yang Ling Lin , Chen Yue , Fu Shao Zhi , Wu Jing Bo 
Published: October 2016

Colorectal peritoneal carcinomatosis (CRPC) is a common systemic metastasis of intra‐abdominal cancers. Intraperitoneal chemotherapy against CRPC is at present the preferred treatment. The aim of this study is to develop a novel hydrogel drug delivery system through the combination of 5‐fluorouracil (5‐FU) loaded polymeric micelles and cisplatin (DDP) in biodegradable thermosensitive chitosan (CS) hydrogel. The prepared CS hydrogel drug is a free‐flowing solution at room temperature and forms a stationary gel at body temperature. Therefore, a CRPC mouse model is established to investigate the antitumor activity of CS hydrogel drug system. The results suggest that intraperitoneal administration of CS hydrogel drug can inhibit tumor growth and metastasis, and prolong survival time compared with other groups, thus improving the chemotherapeutic effect. Ki‐67 immunohistochemical analysis reveals that tumors in the CS hydrogel drug group has lower cell proliferation in contrast to other groups (P < 0.001). Furthermore, hematoxylin‐eosin staining of liver and lung tissue indicates that the CS hydrogel drug has also a certain inhibitory effect on colorectal cancer metastasis to the liver and lung. Hence, the work highlights the potential clinical applications of the CS hydrogel drug.
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Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction
Authors: Han Hui , Zhu Jinzhou , Wang Yaqiong , Zhu Zhengbin , Chen Yanjia , Lu Lin , Jin Wei , Yan Xiaoxiang , Zhang Ruiyan 
Published: October 2016

AbstractRenal fibrosis is a significant threat to public health globally. Diverse primary aetiologies eventually result in chronic kidney disease (CKD) and immune cells influence this process. The roles of monocytes/macrophages, T cells, and mast cells have been carefully examined, whilst only a few studies have focused on the effect of B cells. We investigated B‐cell function in tubulointerstitial fibrosis induced by unilateral ureteral obstruction (UUO), using genetic B‐cell‐deficient μMT mice or CD20 antibody‐mediated B‐cell‐depleted mice. Obstructed kidneys of μMT and anti‐CD20‐treated mice showed lower levels of monocyte/macrophage infiltration and collagen deposition compared to wild‐type mice. Mechanistically, anti‐CD20 attenuated UUO‐induced alterations of renal tumour necrosis factor‐α (TNF‐α), vascular cell adhesion molecule 1 (VCAM‐1) pro‐inflammatory genes, and CC chemokine ligand‐2 (CCL2) essential for monocyte recruitment; B cells were one of the main sources of CCL2 in post‐UUO kidneys. Neutralization of CCL2 reduced monocyte/macrophage influx and fibrotic changes in obstructed kidneys. Therefore, early‐stage accumulation of B cells in the kidney accelerated monocyte/macrophage mobilization and infiltration, aggravating the fibrosis resulting from acutely induced kidney nephropathy. © 2016 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Improving on equilibrium isotropic nuclear shielding constants
Authors: Ng Yee‐Hong , Bettens Ryan P. A. 
Published: October 2016

AbstractIsotropic nuclear shielding constants at the equilibrium molecular structure σeq and zero‐point vibrational corrections (ZPVCs) to σeq are evaluated using the B3LYP/aug‐cc‐pVTZ level of theory, as well as the KT2/aug‐cc‐pVTZ level of theory. Various scaling factors and systematic corrections are obtained by linear regression to experimental shielding constants. Comparisons of the scaled and systematically corrected equilibrium and vibrationally averaged shielding constants reveal that, at the 99% confidence level, the ZPVCs via second‐order perturbation theory do not improve the agreement of B3LYP/aug‐cc‐pVTZ and KT2/aug‐cc‐pVTZ calculated shielding constants with experiment. This holds true when the same analysis is applied to CCSD(T)/aug‐cc‐pCV[TQ]Z calculated σeq of Teale et al. [Journal of Chemical Physics 2013, 138, 024111]. In addition, at the 99% confidence level, B3LYP/aug‐cc‐pVTZ and KT2/aug‐cc‐pVTZ scaled and systematically corrected shielding constants are found to be statistically no different from CCSD(T)/aug‐cc‐pCV[TQ]Z calculated σeq. The use of scaling factors and systematic corrections could thus provide a cheaper but yet reasonably accurate alternative for the study of nuclear shielding constants of larger systems.