bluuebunny/crossref_metadata_2025_split huggingface dataset:
On‐call simulation: Evaluating cost and impact
Authors: Scott Rachel , Chumbley Samuel D. , Miles Maria , Beattie Clodagh , Grewal Anive 
Published: September 2024

AbstractBackgroundOn‐call simulation has been shown to improve the confidence of prospective junior doctors in undertaking on‐call shifts. Despite this, it is not mandated in UK medical school curricula, leading to variations in provision. Barriers to widespread implementation may include doubts surrounding effectiveness, feasibility of delivering on‐call simulation across multiple sites and unknown costs. To address these gaps in the literature, we designed and implemented a multi‐site on‐call simulation programme. We aimed to evaluate it both educationally, using student preparedness to complete on‐call shifts as our outcome, and economically, by performing a cost‐outcome description.ApproachAn on‐call simulation programme, ‘Bleep 101’, was developed and implemented at eight hospitals. Students were ‘bleeped’ around a circuit of written scenarios including clinical emergencies, prescribing and distractor tasks. Students could escalate to their facilitator on the phone for advice at any time. Sessions concluded with a 30‐minute debrief focusing on prioritisation and communication skills.EvaluationBetween 2018 and 2023, 217 students took part and completed feedback forms. Post‐session feedback using Likert scales demonstrated a significant increase in preparedness to complete an on‐call shift (pre‐4/10, post‐7/10, p < 0.01) with outcomes consistent across sites. A cohort of 20 students completed paired pre‐ and post‐session feedback to evaluate the impact of the session on specific skills. This demonstrated increased confidence in using a bleep, prioritisation, gathering information and handing over. The costs of implementation at one site were reported, demonstrating a cost of £1.99/student/year or £99.48/student/year excluding costs saved by volunteers and room hire.ImplicationsThis study indicates that on‐call simulation can be delivered at a low cost using existing medical education infrastructure within hospitals. Results suggested an improvement in medical students' preparedness for on‐call practice. We therefore recommend on‐call simulation be available to all medical students as part of medical school curricula.
Tendril length is determined by gibberellin deactivation during thigmo response in cucumber
Authors: Fan Zipei , Zhou Chenhao , Wang Xu , Sun Zhihui , Wang Xinrui , Hong Zezhou , Yan Guochao , He Yong , Zhu Zhujun , Xu Yunmin 
Published: September 2024

SUMMARYChanges in plant morphology due to mechanical stimulation are known as thigmo responses. As climbing organs in plants, tendrils can sense mechanical stimulation after attaching to a support and then change their morphology within a short time. Here, the thigmo responses of cucumber tendril were investigated. Our results showed that mechanical stimulation stopped tendril elongation and that tendril length was determined by the distance from the support in cucumber. The mimicry touch treatment indicated that mechanical stimulation stopped tendril elongation by inhibiting cell expansion. RNA‐seq data showed that three gibberellin (GA) metabolic genes (CsGA2ox3, CsCYP714A2, and CsCYP714A3) were upregulated in mechanically stimulated tendrils, and a major endogenous bio‐active GA (GA4) was reduced in mechanically stimulated tendrils. The roles of CsGA2ox3, CsCYP714A2, and CsCYP714A3 in GA deactivation were confirmed by their overexpression in transgenic Arabidopsis. Moreover, exogenous GA treatment recovered tendril elongation under mechanical stimulation, whereas exogenous uniconazole treatment inhibited tendril elongation without mechanical stimulation, suggesting that mechanical stimulation stopped tendril elongation, depending on GA deactivation. In summary, our results suggest that GA deactivation plays an important role in tendril thigmo response, ensuring that tendrils obtain a suitable final length according to their distance from the support in cucumber.
Canine pigmented viral plaques associated with application of potent topical glucocorticoids
Authors: De Lucia Michela , Denti Daria , Werlen Nadine Angie , Ramsauer Anna Sophie 
Published: September 2024

AbstractA six‐year‐old atopic boxer presented with pigmented viral plaques on the interdigital spaces and pinnae following treatment with potent topical glucocorticoids. The lesions regressed after treatment was discontinued, and recurred each time a topical glucocorticoid was resumed. A Chipapillomavirus was amplified from lesional tissue.
Comparative Analysis of Simultaneous Electrochemical and Electrodischarge Machining Process
Authors: Sharma Sahil , Dvivedi Akshay 
Published: September 2024

Abstract
Recent advances have established electrochemical discharge machining (ECDM) as an effective alternative to electrical discharge machining (EDM) for producing microholes in conductive materials. However, ECDM leaves nonuniform layers, including recast layers and heat-affected zones, rendering it unsuitable for materials vital to aerospace, defence, and biomedical applications. To address this issue, the present work investigates a novel electrochemical machining (ECM)-based frugal engineering process known as simultaneous electrochemical and electrodischarge machining (SECEDM) for microhole fabrication. To evaluate the process effectiveness, the machining results of the SECEDM process were compared with ECDM, EDM, and ECM. The obtained results present the fundamental distinction between the process mechanism of SECEDM and ECDM. SECEDM has been reported to produce microholes with improved machined surfaces characterized by their freedom from recast layer and ECDM-induced defects. Moreover, SECEDM facilitated meticulously controlled high-speed anodic dissolution of work material, surpassing the material removal rate (MRR) achieved through ultrasonic-assisted ECDM (U-ECDM), ECM, and EDM processes by 2.67, 4.2, and 6.2 times, respectively. Furthermore, the substantial 67.72% and 68.82% reduction in the average machined hole diameter than ECM and U-ECDM, respectively, with a noteworthy 13.69% enhancement in average roundness error achieved while maintaining the repeatability accuracy with an accuracy range within ±0.009 mm through SECEDM process underscore SECEDM's accuracy and repeatability. In addition, lower surface roughness by 31.6% and 68% compared to ECM and EDM, along with reduced carbon and oxygen content as examined through energy dispersive X-ray (EDX) analysis, signifies the SECEDM process efficiency in microfabrication.
Assessment of Tissue Eosinophilic Infiltration in Invasive Mammary Carcinoma
Authors: Hasan Farah Falah , Fadhil Mohammed Haider , Almukhtar Zainab Khalid 
Published: September 2024

Background: Stromal inflammatory cells in malignant tissue have recently gained increasing interest. Unlike the extensive research on tumor‐infiltrating lymphocytes, published data about tumor‐infiltrating eosinophils in breast cancer are scarce. Furthermore, similar studies have yet to be conducted in Iraq.Aims: The objective of this study is to examine the presence of eosinophilic infiltration by direct visualization using light microscopy and to analyze its relationship with other histological parameters in a group of Iraqi women diagnosed with invasive mammary cancer.Methods and material: A retrospective study enrolled 90 histological samples of invasive mammary carcinoma provided by core needle biopsy from a single center, together with their immunohistochemical results for ER and HER2‐NEU. Data reviewing, direct morphological visualizations, and counting eosinophilic infiltration in tissue sections were done by two independent pathologists using light microscopy. The results were statistically correlated with the grade, ER, HER2‐NEU, calcification, and axillary lymph node status at presentation.Results: Out of the entire sample size (90), 40 (44%) showed the presence of eosinophilic infiltration in the tissue, both intratumoral and stromal. Further analysis revealed that most eosinophilic infiltrates had an intermediate score (4−19) per 10 consecutive high‐power fields. A strong and meaningful statistical relationship was seen between tissue eosinophilic infiltration and HER2/NEU status. A statistically insignificant correlation was seen between tissue eosinophilic infiltration and histological grade, ER receptor status, calcification, and axillary lymph node status at presentation.Conclusions: Eosinophils are tumor‐infiltrating cells in breast cancer, both intratumoral and stromal. The presence of tissue eosinophilic infiltration can predict HER2/NEU negativity in breast cancer.
PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma
Authors: Nassar Khaled Mohamed , Yang Xue , Baker Adriana , Gopalam Rahul , Arnold William C. , Adeniran Timilehin T. , Hernandez Fernandez Marian H. , Mahajan Megharani , Lai Zhao , Chen Yidong , Sareddy Gangadhara R. , Viswanadhapalli Suryavathi , Sun Lu-Zhe , Vadlamudi Ratna K. , Pratap Uday P. 
Published: September 2024

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the United States, with a median survival period of approximately 10 months. There is an urgent need for the development of effective targeted therapies for the treatment of HCC. Proline-, glutamic acid–, and leucine-rich protein 1 (PELP1) signaling is implicated in the progression of many cancers, although its specific contribution to the progression of HCC is not yet well understood. Analysis of The Cancer Genome Atlas HCC gene expression data sets and IHC analysis of HCC tissue microarray revealed that HCC tumors had elevated expression of PELP1 compared with normal tissues, and high expression of PELP1 is associated with unfavorable survival outcomes. Suppression of PELP1 expression using short hairpin RNA significantly reduced the cell viability, clonogenicity, and invasion of HCC cells. Importantly, SMIP34, a first-in-class small-molecule inhibitor targeting PELP1, effectively decreased the cell viability, clonogenic survival, and invasiveness of HCC cells. Gene expression analysis using RNA sequencing revealed that PELP1 knockdown cells exhibited a decrease in c-Myc, E2F, and other oncogenic pathways related to HCC. Mechanistic studies showed that SMIP34 treatment impaired the Rix complex, a critical component of ribosomal biogenesis, in HCC cells. Furthermore, the knockdown or pharmacologic inhibition of PELP1 significantly decelerated the HCC tumor growth in xenograft models. In summary, our study findings indicate that PELP1 could serve as a promising target for therapeutic intervention in HCC.

Significance:
HCC is one of the leading causes of cancer fatalities in the United States. Effective targeted therapeutics for HCC are urgently needed. In this study, we show that PELP1 proto-oncogene is crucial to HCC progression and that PELP1 inhibition reduced HCC cell proliferation in vitro and in vivo. Our results imply that PELP1-targeted drugs like SMIP34 may be useful as new therapeutic agents for HCC treatment.
Condição de moradia: sensibilidades de fronteira numa ocupação em São Paulo
Authors: Oliveira Frederico Jorge Tavares de 
Published: September 2024

Neste artigo, examinamos as condições históricas e situacionais de um projeto de moradia, isto é, uma ocupação, cujas especificidades serão observadas a partir de dados secundários e contextuais, sobretudo a partir da maneira como interagíamos com os ocupantes, observando a maneira como eles se manifestavam e/ou explicavam sua ação, suas motivações e sentimentos, assim como a maneira que a Defensoria Pública do Estado de São Paulo procurou evitar a reintegração de posse. Sob forte inspiração de estudos de comunicação e consumo, especialmente de Néstor García Canclini, acreditamos retomar, assim, uma característica histórica fundamental dos estudos culturais: fazer teoria sociocultural com suportes empíricos a fim de compreender criticamente o devir capitalista.
Repetitions Within and Between Chapters in the Xunzi 荀子: Traces of Liu Xiang’s 劉向 Editorial Work
Authors: Liu Meihui 
Published: September 2024

Abstract
While the Xunzi 荀子 is often taken as a coherent text authored by the historical Xun Kuang 荀況 (ca. 314–ca. 238 BCE), it exhibits discontinuities and high rates of repetition, suggesting that many chapters are compilations, not single-author texts. Some meaningful parallels indicate the presence of a skillful compiler who collected variations on the same topic. The best candidate for such an editor appears to be Liu Xiang 劉向 (79–8 BCE). While Liu claimed to have deleted a large number of “duplicates” from his materials, he also seems to have purposefully integrated some of them into his final version of the text. Thereafter, a pian 篇 (chapter) was no longer the same as its pre-Han ancestor; it had become longer and more comprehensive, yet not a linear unit of meaning.
The Life and Works of the Monk Donggao, a Chinese Chan Master in Japan
Authors: van Gulik Robert H. 
Published: September 2024

Abstract
In this article Dr. van Gulik (1910–1967) explores the life and times of the Chinese Buddhist monk Donggao 東皐 (1639–1695) who was not willing to live under the Manchu conquerors and left China for Japan. After his arrival in early 1677 he met with hostility, but, thanks to the intercession by his patron, prince Tokugawa Mitsukuni 德川光圀, he was able to stay in Japan, founded a new branch of the Chan school, the Shouchang sect 壽昌, and became the first abbot of this branch at Gionji 祇園寺 in Mito. The erudition of Donggao, and his skill in seal carving, calligraphy, lute-play and poetry, was much admired by Japanese monks and scholars. Dr. van Gulik presents numerous examples of his cultural endeavors, taken from his own sizable collection. This article was written by Dr. van Gulik in 1941 shortly before the Pacific War broke out, resulting in postponement of its publication. The type-written manuscript is now part of the Robert van Gulik archives in the East Asian Library at Leiden University.
Social Exclusion and Contemporary Marginalisation: a Case of Egyptian Nubians
Authors: Ma Weiyu 
Published: September 2024

Abstract
Every multi-ethnic state faces ethnic competition and ethnic marginalisation, with minorities often facing varying degrees of discrimination, and power repression. The study adopts the theory of marginalisation and combines historical discourse analysis to examine the marginalisation experienced by Nubians in Egypt. The study finds that the marginalisation suffered by Nubians in Egypt is mainly reflected in the political denial of Nubians’ right to return and inadequate political elections, the economic lack of access to basic services and labour market challenges, as well as the education inequality, and that the state of marginalisation of the Nubian community is still ongoing. The study suggests that in the context of the Egyptian government’s continued neglect of Nubians’ rights and needs, Nubians should create pluralistic Nubian civil social organisations, increase the participation of the Nubian groups in Egyptian society, and create a vibrant public space for the Nubians to reduce the increasing marginalisation.
Is Acts Really “The Most Overtly Missionary Book”?
Authors: Tupamahu Ekaputra 
Published: September 2024

Abstract
The aim of this article is twofold: first, to challenge the white reading of the book of Acts, and second, to offer an alternative reading by placing the story of the marginalized people, the colonized people, at the center. The first part of this article interrogates how white pentecostal scholars read the book of Acts as a missionary book and identify themselves with the disciples in the book of Acts. After presenting the problems with this reading, I propose an alternative interpretation of the movement in Acts as a migration movement instead of a missionary movement. Reading it from a migration point of view centers on the story of a marginalized group of people trying to find a safe place to live because of the sociopolitical instability in their homeland.
Vindicating Spirit, Deceiving Spirits
Authors: Bowes William 
Published: September 2024

Abstract
The first letter to Timothy includes a reference to a primitive hymnic formula that grants a central role to the Holy Spirit in Jesus’s resurrection. This reference coheres with other primitive (pre-Pauline) references such as Rom 1:3–4 and with Paul’s earlier teaching on the Spirit (as in Rom 8:11). In a letter that seems otherwise sparse in its pneumatology, 1 Tim 3:16 is important for understanding the relationship between the Holy Spirit and Jesus’s identity, and I suggest that the mention of the Spirit here informs the way that the statements in 4:1–5 should be read, and the way that the letter’s overall portrayal of truth and falsehood should be understood. I will discuss the interpretation of 1 Tim 3:16—4:5, proposing a pentecostal reading of this section of the letter, one that takes seriously the vindicating role of the Spirit in Jesus’s resurrection as a model for believer’s future resurrection, one that coheres with the pneumatology of earlier Pauline epistles, and one that coheres with the treatment of false teachers and demonic spirits in other New Testament texts.
Refined by Fires: the Countercultural Shape of T.C. Chao’s Mature Theology
Authors: Sampson John 
Published: September 2024

Abstract
T.C. Chao (1888–1979) was one of the twentieth century’s most celebrated Chinese Protestant thinkers, renowned in the Chinese Republican era (1912–1949) for his creative and penetrating works of Christian theology. During the Sino-Japanese War (1937–1945), Chao was imprisoned by Japanese military troops and experienced a spiritual and intellectual transformation. Scholars identify a new, mature period of thought arising after imprisonment, one often termed “neo-orthodox.” But this term remains connotatively misleading and sheds scant light on the shape of Chao’s creative theological reflection. In its place this article investigates whether the term “countercultural” is more fitting, in view of three factors that gave shape to Chao’s mature theology, namely, Japanese imprisonment, Karl Barth’s influence, and ordination in the Anglican Church in China.
The Russian Student Christian Movement’s Religious Literature Smuggling Program (1960s–1980s)
Authors: Martin Barbara 
Published: September 2024

Abstract
This article offers an overview of the activities of the Russian Student Christian Movement’s Department of Assistance to Believers of the USSR. Founded in Paris in 1961 by Cyrille Eltchaninoff, it aimed at smuggling religious and dissident literature to the Soviet Union. The charity collected donations to purchase books, which were then sent to Soviet believers through a network of around 150 contacts in 30 countries. In the 1970s–1980s, it smuggled up to 45,000 books to the Soviet Union yearly, provided assistance to prisoners of faith and their families. This article argues that the RSCM acted as a bridge between East and West, supporting the nascent religious revival in the Soviet Union, thanks to an effective fundraising strategy based on support to Soviet dissidents.
Les gestes discursifs dans les conférences TED Talk Synchronisation gestes/parole et prosodie
Authors: Ferré Gaëlle 
Published: September 2024

Abstract
The linguistic contribution of representational gestures has long been the focus of Gesture Studies, but descriptions of other gesture types and of their functions are much more scarse, notably when it comes to pragmatic gestures that play a discourse function. Yet, whereas representational gestures are interesting for the study of their semantic features, discursive gestures reveal the information structure of linguistic messages as well as the foregrounding of some parts of speech. The present study proposes an analysis of four gesture types: beats, points, hand flips and closing hand gestures. They share the function of highlighting discourse units and the hypothesis proposed here is that they do not have the same scope in doing so. Beats and points are local highlighters which emphasize lexical items (words or NPs), whereas hand flips and closing hand gestures frame larger discourse units like Inter-Pausal Units or Turn-Constructional Units, that can be considered as forming oral paragraphs, as well as Intonation Phrases to a lesser extent. The prosodic study of the speech uttered in synchrony with these four gesture types sheds a new light on some of their functions which have so far been described in a qualitative way. It allows us not only to make connections between gestures that are often considered separately, but also to differentiate them.
Mise en place d’un protocole d’identification de traits articulatoires communs à la gestualité co-verbale du français et à la Langue des Signes Française (LSF): application au geste épistémique
Authors: Catteau Fanny , Bianchini Claudia S. 
Published: September 2024

Abstract
This article focuses on the articulatory characteristics of epistemic gestures (i.e., gestures used to express certainty or uncertainty) in co-speech gestures (CSG) in French and in French Sign Language (LSF). It presents a new methodology for analysis, which relies on the complementary use of manual annotation (using Typannot) and semi-automatic annotation (using AlphaPose) to highlight the kinesiological characteristics of these epistemic gestures. The presented methodology allows to analyze the flexion/extension movements of the head in epistemic contexts. The results of this analysis show that in CSG and LSF: (1) head nods passing through the neutral position (i.e., head straight with no flexion/extension) and high movement speed are markers of certainty; and (2) holding the head position away from the neutral position and low movement speed indicate uncertainty. This study is conducted within the framework of the ANR LexiKHuM project, which develops kinesthetic communication solutions for human-machine interaction.
Endogenous phytohormone analysis during sequential stages of somatic embryogenesis in Musa AAA cv. Grand Naine (subgroup Cavendish)
Authors: Kumaravel Marimuthu , Uma Subbaraya , Backiyarani Suthanthiram , Saraswathi Marimuthu Somasundaram , Mayilvaghanan Muthu , Agrawal Anuradha 
Published: September 2024

Abstract
This is the first initiative study to provide quantified levels of four endogenous phytohormones during the induction, regeneration, maturation and germination stages of somatic embryogenesis (SE) in banana, using immature male bud explants, in the popular commercial triploid cultivar Grand Naine (AAA). Phytohormones are known to play a major role in the regulation of SE and most protocols have been developed for various cultivars of banana following empirical approaches. Although, several reports are available with regard to the impact of growth regulators exogenously supplemented to the media, the vital role of endogenous growth hormones in various developmental stages of SE remain unclear in banana. Reverse Phase High Performance Liquid Chromatography (RP-HPLC) was used to analyze endogenous status of indole acetic acid (IAA), zeatin, gibberellic acid (GA) and abscisic acid (ABA). Results from this study revealed that endogenous IAA and GA along with exogenous auxin play a major role in the induction of embryogenic competence of male bud explants. The levels of endogenous IAA and zeatin were found to be higher in embryogenic calli than non-embryogenic calli, although three different types of exogenous auxins were supplemented in callogenesis medium, but not cytokinin. Higher level of ABA and GA was observed in early and late developmental stages of somatic embryo, respectively. GA also played a predominant role in germination of somatic embryos. These findings will be applied for improvement of SE protocol in recalcitrant banana cultivars by suitably altering or supplementing exogenous growth hormones.