bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of advanced regression techniques for predicting ship CO2 emissions
Authors: Lepore Antonio , dos Reis Marco Seabra , Palumbo Biagio , Rendall Ricardo , Capezza Christian 
Published: May 2017

AbstractThe new EU Regulation urges shipping operators to set up systems for the monitoring, reporting, and verification of CO2 emissions. Indeed, new monitoring data acquisition systems installed on modern ships have brought a navigation data overload that needs to be correctly handled to make proper decisions about their operation. However, in today's market, there is no standard solution or method available that can be robustly adopted in real environments for the shipping industry. In view of the novel attempts for solving this issue proposed by statisticians, marine engineers, and practitioners, this paper presents an extensive comparison of several regression techniques that can exploit the navigation information usually available in modern ships: variable selection methods, penalized regression methods, latent variable methods and tree‐based ensemble methods. The comparison is made by means of operational data collected on a Ro‐Pax cruise ship owned by the Italian shipping company Grimaldi Group. The goal of this analysis is twofold: (1) to identify methodologies with more potential at analyzing the data collected from this shipping industry scenario and (2) to develop a predictive model for CO2 emissions with good characteristics of accuracy and robustness.
A simple robust control for global asymptotic position stabilization of underactuated surface vessels
Authors: Xie Wenjing , Ma Baoli , Fernando Tyrone , Iu Herbert Ho‐Ching 
Published: May 2017

SummaryGlobal asymptotic stabilization of underactuated surface vessels is generally achieved only by designing complicated controllers. This paper proposes a very simple control law that globally asymptotically stabilizes the position of underactuated surface vessel to a desired constant location and its velocities to zero. The proposed controller is independent of velocity signals and is robust to model parameters. It neither includes an observer nor an adaptive/sliding‐mode law. Controller development and stability analysis rely on a novel Lyapunov function and LaSalle's theorem. Furthermore, by extending the proposed control strategy, a saturated control law is also obtained ensuring the semiglobal asymptotic stability of position error system. Effectiveness of the proposed control schemes is demonstrated by simulation examples. Copyright © 2017 John Wiley & Sons, Ltd.
A New Sensor for Determination of Anionic Surfactants in Detergent Products with Carbon Nanotubes as Solid Contact
Authors: Sakač Nikola , Jozanović Marija , Karnaš Maja , Sak‐Bosnar Milan 
Published: May 2017

AbstractA new solid‐state sensor for potentiometric determination of surfactants with a layer of multi‐walled carbon nanotubes was prepared. As a sensing material, 1,3‐didecyl‐2‐methylimidazolium–tetraphenylborate ion‐pair was used. The investigated sensor showed a Nernstian response for both dodecylbenzenesulphonate (DBS, 57.6 mV/decade of activity between 5 × 10−7 to 1 × 10−3 M) and sodium lauryl sulfate (LS, 58.4 mV/decade of activity between 2 × 10−7 to 2 × 10−3 M). It responded in 8–10 s for each ten‐fold concentration change in the range of 1 × 10−6 to 3 × 10−3 M. The detection limits for DS and DBS were 2 × 10−7 and 3 × 10−7 M, respectively. The sensor revealed a stable response (signal drift 2.6 mV/h) and exhibited satisfactory selectivity performances for LS over most of the anions generally used in surfactant‐based commercial detergents. The main application of this sensor was the end‐point determination in potentiometric titrations of anionic surfactants. The (diisobutyl phenoxy ethoxy ethyl)dimethyl benzyl ammonium chloride (Hyamine), cetyltrimethylammonium bromide, hexadecylpyridinium chloride monohydrate (HDPC) and 1,3‐didecyl‐2‐methylimidazolium chloride were tested as potential cationic titrants, and all exhibited analytically usable titration curves with well‐defined equivalence points. The standard solution of HDPC was used as a cationic titrant by all potentiometric titrations. The operational life‐time of the sensor described was prolonged to more than 3 months.
IS EVIDENCE OF EVIDENCE EVIDENCE? SCREENING-OFF VS. NO-DEFEATERS
Authors: Roche William 
Published: May 2017

ABSTRACTI argue elsewhere (Roche 2014) that evidence of evidence is evidence under screening-off. Tal and Comesaña (2017) argue that my appeal to screening-off is subject to two objections. They then propose an evidence of evidence thesis involving the notion of a defeater. There is much to learn from their very careful discussion. I argue, though, that their objections fail and that their evidence of evidence thesis is open to counterexample.
Related self-similar statistics of the turbulent/non-turbulent interface and the turbulence dissipation
Authors: Zhou Y. , Vassilicos J. C. 
Published: May 2017

The scalings of the local entrainment velocity$v_{n}$of the turbulent/non-turbulent interface and of the turbulence dissipation rate are closely related to each other in an axisymmetric and self-similar turbulent wake. The turbulence dissipation scaling implied by the Kolmogorov equilibrium cascade phenomenology is consistent with a Kolmogorov scaling of$v_{n}$whereas the non-equilibrium dissipation scaling reported for various turbulent flows in Vassilicos (Annu. Rev. Fluid Mech., vol. 47, 2015, pp. 95–114), Dairayet al.(J. Fluid Mech., vol. 781, 2015, pp. 166–195), Goto & Vassilicos (Phys. Lett. A, vol. 379 (16), 2015, pp. 1144–1148) and Obligadoet al.(Phys. Rev. Fluids, vol. 1 (4), 2016, 044409) is consistent with a different scaling of $v_{n}$. We present results from a direct numerical simulation of a spatially developing axisymmetric and self-similar turbulent wake which supports this conclusion and the assumptions that it is based on.
A new middle Pleistocene (Marine Oxygen Isotope Stage 6) cold herpetofaunal assemblage from the central Iberian Peninsula (Manzanares Valley, Madrid)
Authors: Blain Hugues-Alexandre , Rubio-Jara Susana , Panera Joaquín , Uribelarrea David , Laplana César , Herráez Esther , Pérez-González Alfredo 
Published: May 2017

AbstractMiddle Pleistocene sites that document glacials are relatively rare in the Iberian Peninsula, and as such, the composition of cold small-vertebrate assemblages is almost unknown in southwestern Mediterranean Europe. The archaeological site Estanque de Tormentas de Butarque H-02 in Villaverde, Madrid, in central Spain, recently attributed to Marine Oxygen Isotope Stage (MIS) 6, provides new data on cold small-vertebrate assemblages. Quantitative climate reconstruction and habitat weighting methods applied to the herpetofaunal assemblage reconstruct the terrestrial climatic and environmental conditions that prevailed in central Spain during the penultimate glacial (MIS 6). During MIS 6, the climate was colder (−3.0°C) and slightly wetter (+122.8 mm) than present in the study area. This confirms that temperature variations were not extreme and precipitation was sufficient in southern Mediterranean Europe for the persistence of temperate trees. Paleoenvironmental reconstruction suggests a large representation of dry environments on the overlying plateau, together with a probable corridor of humid meadows and woodlands along the river where the site is located.
Profound Intellectual Disability and the Bestowment View of Moral Status
Authors: VEHMAS SIMO , CURTIS BENJAMIN 
Published: May 2017

Abstract:This article engages with debates concerning the moral worth of human beings with profound intellectual and multiple disabilities (PIMDs). Some argue that those with such disabilities are morally less valuable than so-called normal human beings, whereas others argue that all human beings have equal moral value and that, therefore, each group of humans ought to be treated with equal concern. We will argue in favor of a view that takes points from opposing camps in the debates about the moral worth of humans with such disabilities. Our position, roughly, is this: most humans with PIMDs are persons in the morally significant sense and, therefore, deserve moral consideration equal to that granted to so-called “normal” human beings. Some humans with PIMD may not be persons, but nevertheless deserve moral consideration equal to that of persons because they stand in a special relation to persons.
Impaired cardiac output during exercise in adults operated for ventricular septal defect in childhood: a hitherto unrecognised pathophysiological response
Authors: Asschenfeldt Benjamin , Heiberg Johan , Ringgaard Steffen , Maagaard Marie , Redington Andrew , Hjortdal Vibeke E. 
Published: May 2017

AbstractBackgroundRecent studies have demonstrated that surgical ventricular septal defect closure in childhood is associated with reduced functional capacity and disruption of the right ventricular force–frequency relationship during exercise. To further describe long-term cardiac function, we performed a non-invasive assessment of cardiac index during exercise in adults having undergone surgery for ventricular septal defect in early childhood.MethodsA total of 20 patients (surgical age 2.1±1.4 years, age at examination 22.1±2.2 years) and 20 healthy, matched controls (23.4±2.1 years at examination) underwent continuous supine bicycle ergometry during MRI. Their blood flow was recorded in the ascending aorta and the pulmonary trunk at increasing exercise levels. Cardiac index, retrograde flow, and vessel diameters were determined by blinded, post hoc analyses.ResultsThe patient group had normal cardiac index at rest (2.9±0.7 L/minute/m2), which was comparable with that of the controls (3.0±0.6 L/minute/m2); however, they had a lower increase in cardiac index during exercise (reaching 7.3±1.3 L/minute/m2 at submaximal exercise) compared with controls (8.2±1.2 L/minute/m2), p<0.05. Patients had a significantly higher ascending aorta retrograde flow than controls at rest and throughout exercise. In the pulmonary artery, the retrograde flow was minimal at rest in both groups, but increased significantly in patients during exercise compared with controls.ConclusionsYoung adults with a surgically closed ventricular septal defect have a reduced cardiac index during exercise compared with healthy, young adults. The impaired cardiac index appears to be related to an increasing retrograde flow in the pulmonary artery with progressive exertion.
ADAR1-mediated 3′ UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response
Authors: Yang Chang-Ching , Chen Yi-Tung , Chang Yi-Feng , Liu Hsuan , Kuo Yu-Ping , Shih Chieh-Tien , Liao Wei-Chao , Chen Hui-Wen , Tsai Wen-Sy , Tan Bertrand Chin-Ming 
Published: May 2017

AbstractAdenosine-to-inosine RNA editing constitutes a crucial component of the cellular transcriptome and critically underpins organism survival and development. While recent high-throughput approaches have provided comprehensive documentation of the RNA editome, its functional output remains mostly unresolved, particularly for events in the non-coding regions. Gene ontology analysis of the known RNA editing targets unveiled a preponderance of genes related to apoptosis regulation, among which proto-oncogenes XIAP and MDM2 encode two the most abundantly edited transcripts. To further decode this potential functional connection, here we showed that the main RNA editor ADAR1 directly targets this 3′ UTR editing of XIAP and MDM2, and further exerts a negative regulation on the expression of their protein products. This post-transcriptional silencing role was mediated via the inverted Alu elements in the 3′ UTR but independent of alteration in transcript stability or miRNA targeting. Rather, we discovered that ADAR1 competes transcript occupancy with the RNA shuttling factor STAU1 to facilitate nuclear retention of the XIAP and MDM2 mRNAs. As a consequence, ADAR1 may acquire functionality in part by conferring spatial distribution and translation efficiency of the target transcripts. Finally, abrogation of ADAR1 expression or catalytic activity elicited a XIAP-dependent suppression of apoptotic response, whereas ectopic expression reversed this protective effect on cell death. Together, our results extended the known functions of ADAR1 and RNA editing to the critical fine-tuning of the intracellular apoptotic signaling and also provided mechanistic explanation for ADAR1’s roles in development and tumorigenesis.
ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics
Authors: Ma Yanlei , Yue Jiping , Zhang Yao , Shi Chenzhang , Odenwald Matt , Liang Wenguang G. , Wei Qing , Goel Ajay , Gou Xuewen , Zhang Jamie , Chen Shao-Yu , Tang Wei-Jen , Turner Jerrold R. , Yang Feng , Liang Hong , Qin Huanlong , Wu Xiaoyang 
Published: May 2017

AbstractIn the intestinal epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, which may promote the onset and enhance the severity of inflammatory bowel disease (IBD). However, it remains unclear how the coordinated behaviour of cytoskeletal network may contribute to cell junctional dynamics. In this report, we identified ACF7, a crosslinker of microtubules and F-actin, as an essential player in this process. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. With the mouse genetics approach, we show that ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis in mice. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in human patients. Together, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics contributes to cell adhesion regulation during intestinal wound repair and the development of IBD.
Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells
Authors: Jaspers Maarten , Vaessen Sarah L. , van Schayik Pim , Voerman Dion , Rowan Alan E. , Kouwer Paul H. J. 
Published: May 2017

AbstractThe mechanical properties of cells and the extracellular environment they reside in are governed by a complex interplay of biopolymers. These biopolymers, which possess a wide range of stiffnesses, self-assemble into fibrous composite networks such as the cytoskeleton and extracellular matrix. They interact with each other both physically and chemically to create a highly responsive and adaptive mechanical environment that stiffens when stressed or strained. Here we show that hybrid networks of a synthetic mimic of biological networks and either stiff, flexible and semi-flexible components, even very low concentrations of these added components, strongly affect the network stiffness and/or its strain-responsive character. The stiffness (persistence length) of the second network, its concentration and the interaction between the components are all parameters that can be used to tune the mechanics of the hybrids. The equivalence of these hybrids with biological composites is striking.
Transgenic hepatitis B: a new model of HBV infection
Authors: Daniel Hubert D.-J. , Torbenson Michael 
Published: May 2017

AbstractChronic hepatitis B infection (HBV) is major cause of morbidity and mortality throughout the world. Currently there is limited understanding on the cellular proteins and related molecules involved in the critical steps of viral entry into the cytoplasm and persistent viral replication in cell culture. In order to address these fundamental questions, we designed and implemented a new model of hepatitis B: infectious transgenic hepatitis B virus composed of a complete virus plus a foreign gene. The foreign gene allows identification of cells that are infected by the transgenic virus. The transgenic virus was used in a functional assay to identify cellular proteins necessary for viral replication. This assay repeatedly identified the protein UQCR10. After restoring UQCR10 levels in HepG2 and Huh7 cells, they can be infected by intact virions of transgenic hepatitis B. These results demonstrate the usefulness of this new transgenic hepatitis B model.
Transcriptome responses of Lactobacillus acetotolerans F28 to a short and long term ethanol stress
Authors: Yang Xiaopan , Teng Kunling , Zhang Jie , Wang Fangfang , Zhang Tong , Ai Guomin , Han Peijie , Bai Fengyan , Zhong Jin 
Published: May 2017

AbstractLactobacillus acetotolerans is a major microbe contributing to the Chinese liquor fermentation with unknown function. It can be grown well in a high concentration of ethanol. RNA sequencing (RNA-seq) was performed on L. acetotolerans F28 growing in 12% ethanol to determine important genetic mechanisms for both a short and long term adaption to this environment. A genome-wide transcriptional analysis revealed that the most important genetic elements for L. acetotolerans F28 grown in ethanol are related to high levels of stress response and fatty acid biosynthesis, and a reduction of amino acid transport and metabolism after both a short and long time stress. The fatty acid methyl ester analyses showed that most fatty acids were increased in L. acetotolerans F28 after exposure to ethanol while the unsaturated fatty acid octadecenoic acid (C18:1) was significantly increased. The increasing unsaturated fatty acid biosynthesis in L. acetotolerans F28 might enhance cell membrane fluidity and protect the cells against high concentration of ethanol. Overall, the transcriptome and functional analysis indicated that the elevated stress response and fatty acid biosynthesis, and the decrease of amino acid transport and metabolism might play important roles for L. acetotolerans F28 to adapt to environmental ethanol.
One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons
Authors: Gerbaix Maude , Gnyubkin Vasily , Farlay Delphine , Olivier Cécile , Ammann Patrick , Courbon Guillaume , Laroche Norbert , Genthial Rachel , Follet Hélène , Peyrin Françoise , Shenkman Boris , Gauquelin-Koch Guillemette , Vico Laurence 
Published: May 2017

AbstractThe weightless environment during spaceflight induces site-specific bone loss. The 30-day Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after spaceflight and an 8-day recovery period in mature male C57/BL6 mice. In the femur metaphysis, spaceflight decreased the trabecular bone volume (−64% vs. Habitat Control), dramatically increased the bone resorption (+140% vs. Habitat Control) and induced marrow adiposity invasion. At the diaphysis, cortical thinning associated with periosteal resorption was observed. In the Flight animal group, the osteocyte lacunae displayed a reduced volume and a more spherical shape (synchrotron radiation analyses), and empty lacunae were highly increased (+344% vs. Habitat Control). Tissue-level mechanical cortical properties (i.e., hardness and modulus) were locally decreased by spaceflight, whereas the mineral characteristics and collagen maturity were unaffected. In the vertebrae, spaceflight decreased the overall bone volume and altered the modulus in the periphery of the trabecular struts. Despite normalized osteoclastic activity and an increased osteoblast number, bone recovery was not observed 8 days after landing. In conclusion, spaceflight induces osteocyte death, which may trigger bone resorption and result in bone mass and microstructural deterioration. Moreover, osteocyte cell death, lacunae mineralization and fatty marrow, which are hallmarks of ageing, may impede tissue maintenance and repair.
Delayed Umbilical Cord Clamping at <32 Weeks' Gestation: Implementation and Outcomes
Authors: Bierut Tatiana , Conner Shayna , Tuuli Methodius , Vesoulis Zachary , Macones George , Cahill Alison , Rhoades Janine 
Published: May 2017

Objectives This study aims to evaluate the implementation of a delayed umbilical cord clamping (DCC) protocol for neonates <32 weeks. Secondarily, to evaluate the impact of DCC on maternal outcomes and on the ability to obtain umbilical cord blood gases.
Study Design Retrospective cohort study from November 2014 to March 2016 of patients delivered by 316/7 weeks. In 2014, an institutional protocol for DCC at <32 weeks was implemented. We assessed adherence to the protocol and compared adverse maternal outcomes (utilizing a hemorrhage composite). We evaluated the impact of DCC on the ability to obtain adequate umbilical cord blood gas specimens.
Results Of the 185 patients included in the study, 90 underwent DCC, and 72% of potentially eligible patients appropriately received DCC. There was no significant difference in the maternal hemorrhage composite outcome between DCC and immediate cord clamping (23.3 vs. 36.8%, adjusted odds ratio = 0.64, 95% confidence interval = 0.33, 1.26). There was also no significant difference in the ability to obtain a single or paired umbilical cord blood gas result.
Conclusion Implementation of a DCC protocol for preterm neonates is feasible and was successful. We did not find an increase in maternal risk or a decrease in the ability to obtain umbilical cord blood gases following DCC.
Sulphide stress cracking of 17-4 PH for applications in oilfield components
Authors: Coseglio Mario Sergio Della Roverys 
Published: May 2017

The precipitation-hardening stainless steel 17-4 PH is widely used for oilfield components (tubing hangers and valve stems) due to its favourable combination of high strength and corrosion resistance. In oil and gas production systems containing hydrogen sulphide (H2S), however, this material is highly susceptible to sulphide stress cracking (SSC). Numerous investigations conducted in the past decades outlined its corrosion performance and confirmed its cracking propensity. These studies indicated failures by SSC at low stress levels and highlighted the effects of the main environmental variables: partial pressure of H2S, environment pH, temperature and chloride content. This review describes a series of surface modification techniques, particularly the low-temperature plasma nitriding, which can potentially be used to prevent SSC. This review was submitted as part of the 2017 Materials Literature Review Prize of the Institute of Materials, Minerals and Mining run by the Editorial Board of MST. Sponsorship of the prize by TWI Ltd is gratefully acknowledged
Effects of Waste Plastic on the Physical and Rheological Properties of Bitumen
Authors: Abdullah Mohd Ezree , Ahmad Nurul Asyiqin , Jaya Ramadhansyah Putra , Hassan Norhidayah Abdul , Yaacob Haryati , Hainin Mohd Rosli 
Published: May 2017

Abstract
Plastic disposal is one of the major problems for developing countries like Malaysia, at the same time Malaysia needs a large network of roads for its smooth economic and social development. The limited source of bitumen needs a deep thinking to ensure fast road construction. Therefore, the use of plastic waste in road construction not only can help to protect environment but also able to help the road construction industry. The aims of this research are to study the effects of waste plastic on rheological properties of bitumen. Modified bitumen was prepared by using blending techniques. Bitumen was heated and plastic waste was slowly added. Rheological properties of bitumen were performance by penetration, softening point, viscosity and direct shear rheometer test. The results showed that when content of plastic waste increase, the penetration value, softening point and viscosity of bitumen also increase. Generally, plastic waste improves the performance of bitumen when it was added into bitumen. It can be said that the usage helps to improve the performance of the road pavement which also reduces the rutting effect.