bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adopting HyFlex in Higher Education in Response to COVID-19: Students’ Perceptions and Perspectives
Authors: El Ganbour Rachid , Dihi Mohamed , Bouali Assya 
Published: October 2024

When the coronavirus pandemic was declared as a Public Health Emergency, educational ministries and institutions unanimously opted for distance education as a solution to carry on teaching and learning worldwide. Flexible hybrid courses (HyFlex) are one of the innovative teaching devices that have emerged since the health crisis and aimed to achieve educational continuity and satisfy learners’ various needs. Based on a research model inspired by the different extensions of the technology acceptance model (TAM), we conducted a study with 249 students from the faculty of medicine and pharmacy affiliated with Mohammed First University in Oujda (Morocco) who learned in a HyFlex environment during the 2020–2021 fall semester. The study addressed students’ perceptions regarding the implementation of blended-learning and its dimensions. It aimed to analyse the perceptions of usefulness and ease of use of the HyFlex model and the facilitating conditions and individual characteristics, chiefly the availability of technological resources and the mastery of the computational tool on the behavioural intention of adopting this approach. The results show that attitude, perceived usefulness, perceived ease of use and availability of technological resources are the main factors favouring the acceptance of e-learning by the surveyed students.
Exploring the Design and Application of an Intelligent French Dictation Platform
Authors: Zhai Yuming , Huang (corresponding author) Xiaoliang , Tian Nina 
Published: October 2024

Dictation is considered an efficient exercise for testing French as a foreign language (FFL) learners’ language proficiency. However, the traditional class-based approach to dictation is constrained by the inherent complexity of the exercise’s design, materialisation, and delivery. In this research, we adopted a design-based research approach to design, develop, and apply an intelligent French dictation platform, which we tested on 50 undergraduate FFL learners. By examining their feedback, we identified certain advantages of the platform, such as time–space flexibility, instant correction, and the opportunity to repeat exercises, but also some disadvantages, such as inconvenient text entry, the inability to question a teacher, and the absence of collective learning and supervision. Crucially, this study constitutes an encouraging step forward in classifying frequent errors made by Chinese learners. The results provide a starting point for developing more advanced dictation platforms that will be capable of automatised error classification in the future.
Changements des gestes professionnels des enseignants du présentiel au distanciel
Authors: Aberkane Chaymae , El Mouhsine Sara , Azzimani Toufik 
Published: October 2024

L’année 2020 a été marquée par la crise sanitaire provoquée par la COVID-19, par conséquent, le passage brutal d’une modalité d’enseignement apprentissage en présentiel vers une modalité totalement à distance a été imposé. Ce changement de modalité a mis les acteurs concernés dans une situation inédite, dans laquelle, ils étaient incités à adapter leurs pratiques pédagogiques notamment leurs gestes professionnels avec une modalité d’enseignement totalement en ligne. Ce travail de recherche part de deux objectifs principaux : identifier d’abord les difficultés rencontrées par les enseignants pour faire face à ce changement, puis repérer l’impact de ce mode d’enseignement sur les gestes professionnels à la lumière du modèle de Jorro (2005). Pour ce faire, nous avons opté pour une recherche qualitative réalisée à travers des entretiens semi-directifs avec quarante enseignants appartenant aux différents établissements de l’Université Mohammed Premier. Ces enseignants ont manifesté des difficultés quant à la mise en place des gestes professionnels dans un contexte d’enseignement à distance. Ces difficultés ont engendré par la suite des changements résidant dans l’apparition et la suppression de certains gestes.
The Inhibitory Effects of a Factor B–Binding DNA Aptamer Family Supersede the Gain of Function of Factor B Variants Associated with Atypical Hemolytic Uremic Syndrome
Authors: Duan Huiquan , Zhang Ying , Otis Matthew R , Drolet Daniel W , Geisbrecht Brian V 
Published: October 2024

Abstract
Aptamers are short, single-stranded oligonucleotides that selectively bind to target biomolecules. Although they generally exhibit good binding specificity, their affinities are often limited because of the relative lack of hydrophobic groups in nucleic acids. Chemically modified nucleotides incorporating hydrophobic structures into uracil have been synthesized to address this obstacle. Modified DNA aptamers containing such nonstandard nucleotides have been developed for &gt;20 different complement proteins. These modified aptamers show increased affinity and enhanced serum stability and have potential value as therapeutic agents. We recently conducted a structure/function study on a family of modified DNA aptamers that bind specifically to complement Factor B (FB). This work revealed that these aptamers selectively inhibit the complement alternative pathway (AP) by preventing the formation of the AP complement component C3 (C3) proconvertase complex, C3bB. Certain patients with atypical hemolytic uremic syndrome express gain-of-function variants of FB that enhance the formation of the proconvertase complex and/or decrease the efficacy of endogenous regulators against the C3 convertases they form. To investigate whether these FB-binding aptamers could override the effects of disease-causing mutations in FB, we examined how they interacted with several FB variants, including D279G, F286L, K323E, and K350N, in various assays of complement function. We found that the inhibitory effect of the FB-binding aptamers superseded the gain-of-function mutations in FB, although the aptamers could not dissociate preformed C3 convertases. These findings suggest that FB-binding aptamers could be further developed as a potential treatment for certain atypical hemolytic uremic syndrome patients or those with other diseases characterized by excessive complement activity.
МЕТОДЫ ПЕРЕРАБОТКИ ОТХОДОВ ГОРНО-МЕТАЛЛУРГИЧЕСКОГО ПРОИЗВОДСТВА
Authors: Бейсебаева А.С. , Жарылкан С.М. , Есжан Е.Н. , Азат С. 
Published: October 2024

Горно-металлургическая промышленность является значительным источником разнообразных отходов, которые требуют утилизации или повторного использования. В последние годы возрос интерес к разработке технологий и процессов, направленных на использование этих отходов для получения новых материалов, что имеет важное значение для снижения нагрузки на окружающую среду и оптимизации ресурса потребления. В данной работе рассматриваются основные методы и технологии получения материалов из горно-металлургических отходов, их преимущества и перспективы применения. В работе представлен обзор наиболее эффективных технологий по извлечению различных видов сырья и готовой продукции из горно-металлургической промышленности. Показаны разработанные технологии извлечения ценных компонентов из отходов производства на основании проведенных лабораторных исследований. В данной работе были получены наночастицы диоксида кремния, геополимерный материал, материал, содержащий фазовый электропроводящий состав
Тау-кен металлургия өнеркәсібі кәдеге жаратуды немесе қайта пайдалануды қажет ететін әртүрлі қалдықтардың маңызды көзі болып табылады. Соңғы жылдары осы қалдықтарды жаңа материалдар алу үшін пайдалануға бағытталған технологиялар мен процестерді дамытуға қызығушылық артты, бұл қоршаған ортаға түсетін зиянды азайту және ресурстарды тұтынуды оңтайландыру үшін маңызды. Бұл жұмыста тау-кен және металлургиялық қалдықтарынан материалдарды алудың негізгі әдістері мен технологиялары, олардың артықшылықтары мен қолдану перспективалары қарастырылады. Жұмыста тау-кен металлургия өнеркәсібінен шикізат пен дайын өнімдердің әртүрлі түрлерін алудың ең тиімді технологиялары қарастырылған. Өндіріс қалдықтарынан бағалы компоненттерді алудың әзірленген технологиялары зертханалық зерттеулер негізінде көрсетілген. Жұмыста сирек кездесетін металл кенінің қалдықтарынан кремний диоксиді бар материал, геополимерлі материал, құрамында электрөткізгіштік фазасы бар материал алынды
The mining and metallurgical industry is a significant source of a variety of waste that requires disposal or reuse. In recent years, there has been increased interest in the development of technologies and processes aimed at using these wastes to produce new materials, which is important for reducing the burden on the environment and optimizing resource consumption. This paper discusses the main methods and technologies for obtaining materials from mining and metallurgical waste, their advantages and prospects for application. The paper provides an overview of the most effective technologies for the extraction of various types of raw materials and finished products from the mining and metallurgical industry. The developed technologies for extracting valuable components from production waste are shown based on laboratory studies. In this work, the following materials were obtained: silicon dioxide nanoparticles, geopolymer material, material containing a phase conductive composition
ИССЛЕДОВАНИЕ ВОЗМОЖНОСТИ ПЕРЕРАБОТКИ ТЕХНОГЕННЫХ ОТХОДОВ МЕСТОРОЖДЕНИЯ ЖАЙРЕМ НА РАСТВОРЫ ФОСФАТИРОВАНИЯ
Authors: Раимбекова А.С. , Капралова В.И. , Кубекова Ш.Н. , Жусупова Л.А. 
Published: October 2024

Данная работа посвящена решению проблемы переработки отходов горнодобывающих производств путем создания на их основе и использования фосфатирующих растворов, образующих конверсионные антикоррозионные покрытия на поверхности стальных конструкций. Показано, что получение марганецсодержащего раствора фосфатирования возможно на основе вскрышных отходов м. Жайрем фосфорнокислотным выщелачиванием. Выявлены оптимальные условия процесса выщелачивания, изучен химический состав и технические показатели полученного раствора фосфатирования. Проведены кор- розионные испытания фосфатных покрытий, образованных на стальных образцах (Ст3) в фосфатирующем растворе, полученном при фосфорнокислотном выщелачивании вскрышных отходов.
Бұл жұмыс тау-кен өндірісінің қалдықтарын олардың негізінде жасау және болат конструкцияларының бетінде конверсиялық коррозияға қарсы жабындар түзетін фосфаттандырғыш ерітінділерді пайдалану арқылы қайта өңдеу мәселесін шешуге арналған. Жайрем кен орнының аршу қалдықтары негізінде құрамында марганец бар фосфаттау ерітіндісін алу фосфорқышқылды шаймалау арқылы мүмкін болатындығы көрсетілген. Шаймалау процесінің оңтайлы шарттары анықталды, алынған фосфаттау ерітіндісінің химиялық құрамы мен техникалық көрсеткіштері зерттелді. Аршу қалдықтарын фосфор қышқылымен шаймалау кезінде алынған фосфат ерітіндісінде болат үлгілерде (Ст3) түзілген фосфат жабындарына коррозиялық сынақтар жүргізілді
This work is devoted to solving the problem of processing mining waste by creating based on them and using phosphating solutions that form conversion anti-corrosion coatings on the surface of steel structures. It is shown that production of manganese-containing phosphating solution is possible on the basis of overburden wastes of Zhayrem by phosphoric acid leaching. The optimal conditions of the leaching process were identified, the chemical composition and technical indicators of the resulting phosphating solution were studied. Corrosion tests were carried out on phosphate coatings formed on steel samples (St3) in a phosphating solution obtained during phosphate leaching of overburden waste
Exploring the association between SLC11A1 and CARD15 gene polymorphisms and tuberculosis susceptibility in Holstein cattle
Authors: Bejaoui Safa , Fehri Nour Elhouda , Ferchichi Mohamed Amine , Jemmali Bayrem 
Published: October 2024

Abstract. Bovine tuberculosis (bTB) is a contagious disease that has a socio-economic impact on familial and industrial farms. Genetic selection can improve resistance against bTB. This study aimed to characterize the links between SLC11A1 and CARD15 gene polymorphisms and tuberculosis (TB) susceptibility. In total 200 animals were used (50 cases and 150 controls). Polymorphisms in the SLC11A1 and CARD15 genes were identified and analyzed with the restriction fragment length polymorphism (PCR-RFLP) method. Our results report the PstI PCR-RFLP marker for the SLC11A1-SNP1 site and the StyI PCR-RFLP marker for the CARD51-SNP1 site in Tunisian Holstein cows. Statistical analysis showed a significant association between SLC11A1-SNP1, CARD15-SNP1 and susceptibility/resistance to TB (P < 0.05). Two SLC11A1-SNP1 genotypes were susceptible to tuberculosis, i.e., the heterozygote CG and the homozygote CC, while one SLC11A1-SNP1 genotype, i.e., the GG mutated homozygote, was less susceptible to infection. Concerning the CARD15 gene, two genotypes are highly sensitive to the incidence of bovine tuberculosis, i.e., AA and AG, while the GG genotype is more beneficial and more tolerant of Mycobacterium bovis. SLC11A1 and CARD15 are two useful candidate genes associated with tuberculosis, and this information can be used to improve the health status of domestic cattle and humans.
Juventude e os Desafios do Ensino Médio: Diversidade, Desenvolvimento e Transição
Authors: Silva Liliane Dias Rocha , Vieira Timoteo Madaleno 
Published: October 2024

O ensino médio caracteriza um período significativo para a juventude, pois implica a preparação para transições importantes. Este trabalho objetiva explorar os desafios que os jovens estudantes encontram no decurso do ensino médio e como esses obstáculos podem se correlacionar com os espaços educativos. Para tanto, foram utilizados artigos, dissertações e teses provenientes das bases de dados do Portal de Periódicos da Capes, Biblioteca Digital Brasileira de Teses e Dissertações – BDTD e Scielo Brasil, do período de 2018 a 2024. Ao final, foram selecionados 13 trabalhos correspondentes ao período da pesquisa; outros, anteriores ao intervalo indicado, também foram utilizados, justificados pelo rigor e importância acerca desta temática. Baseando-se em estudos como Dayrell (2003, 2014), Carrano (2014), Lebourg e Coutrim (2018), Krawczyk (2011, 2014), que discutem juventude e ensino médio, estabeleceu-se a revisão bibliográfica para conceituar essa categoria, pautar sobre os desafios do ensino médio e dialogar sobre a influência dos espaços educativos nessa fase de ensino. Concluiu-se que esse período escolar exerce função preponderante na trajetória educacional dos estudantes, em que a juventude está inserida. Desafios, descobertas, dúvidas e tomadas de decisões são inerentes a esse período, bem como a oportunidade de adquirir conhecimento, a formação da identidade e o desenvolvimento de valores éticos e culturais. A pesquisa revelou que, especialmente no ensino médio, os jovens têm a necessidade de que os espaços educativos reconheçam as complexidades inerentes a essa fase e também desenvolvam práticas que promovam a formação educacional em todas as suas dimensões.
Food consumption, type 2 diabetes mellitus and weight status among adults in the Lingwala Health Zone, Kinshasa, the Democratic Republic of the Congo
Authors: Sikayako Kikwayabo Marthe , Kekemb Bukele Théophane , Mupenda Bavon 
Published: October 2024

Background With the epidemiological transition, non-communicable diseases are now a major problem, including in the Democratic Republic of the Congo, where the population’s eating habits are constantly changing, with obesity and hyperglycemia in increase. This study aimed to examine the association between dietary habits, factors associated with type 2 diabetes mellitus and weight status in people over 18 years of age in Kinshasa, Democratic Republic of the Congo. Methods In a descriptive cross-sectional study among 182 adults, selected using multistage probability sampling (Health Zone, Health Area, Household, Individual), a structured questionnaire was used to collect behavioural data. The World Health Organization (WHO) Anthro plus was used to calculate body mass index. Descriptive statistics were completed with the Chi2 test, whereas a multivariate analysis used correlation with 95% confidence interval (CI) with eating habits, glycemic status and weight status as major variables. Results There were 68.8% respondents with high weight trouble (44.4% overweight and 24.0% obese). Up to 14.8% respondents were both overweight and hyperglycemic. Only 14.8% respondents reading labels of paid products was associated with glycemic status (P<0.05). Up to 61.5% respondents reported preparing own food, 54.4% eating alone, 96.7% consuming oils, sugar and sweet products, 92.9% consuming milk and its derivatives, 85.2% meat and fish, and 82.4% consumed fruits. However, none of these parameters was significantly associated with glycemic status Conclusions Stakeholders, including MoH, community, and civil society need to partner in raising awareness for changing behavior and eating habits such as mindful eating, balanced diet and regular eating.
THE IMPERATIVE OF INSTITUTING A MILITARY OMBUDSMAN AND ITS POTENTIAL FRAMEWORKS
Authors: Koval Oleksandr 
Published: October 2024

The Secretariat of the Human Rights Commissioner of the Verkhovna Rada of Ukraine includes the Department for Monitoring the Observance of Rights in the Defense Sector and the Rights of Veterans and Servicemen, Prisoners of War and Their Family Members. The Department’s main task is to ensure that the Parliamentary Commissioner for the Observance of the Constitutional Rights and Freedoms of Servicemen exercises his or her powers.
During 2022, the Human Rights Commissioner recorded a more than twenty-fold increase in appeals by servicemen regarding the violation of their rights compared to the previous year. In addition, the range of issues on which servicemen and their family members are appealing has expanded. In 2020–2021, the majority of appeals and complaints were related to military service conditions, timely payments, including adequate financial support for the families of fallen servicemen, pension recalculations, and non-compliance by the Pension Fund of Ukraine and other state bodies with court decisions restoring the rights of military personnel, military pensioners and members of their families. During 2022–2023, appeals also included the search for missing persons and the return of captives. The latter account for 72 % of all appeals.
At the same time, the percentage of responses to these appeals is extremely low. The published data indicate that the Department for Monitoring the Observance of Rights in the Defense Sector and the Rights of Veterans and Servicemen, Prisoners of War and Their Family Members might not fully cover social and legal protection of these groups.
The low response rate compared to the volume of complaints about human rights violations in the security and defense sector may be due to the lack of funding and the lack of qualified specialists. Given the ongoing war between the Russian Federation and Ukraine, the number of appeals will increase, and the volume of unresolved issues will most likely accumulate.
Therefore, taking current realities into account, the increase in the number of servicemen and other defense sector employees, it is advisable to follow best practices worldwide and separate the institute of the military ombudsman from the institute of the Parliamentary Human Rights Commissioner. This can be done by introducing an appropriate legislative act and establishing an independent structure with expanded powers regarding veterans, prisoners of war and civilian hostages with its own financing and staff.
FORCED INTERNAL DISPLACEMENT OF THE UKRAINIAN POPULATION: RISKS RAISED BY WAR
Authors: Malynovska Olena , Yatsenko Liubov 
Published: October 2024

The large-scale war forced millions of Ukrainians to leave their homes in search of safety. The mass displacement of the population led to an increase in the level of uncertainty and raised risks for both individuals and the whole of society. This article aims to assess the scale of internal migration in Ukraine during the war and to investigate the impact of this phenomenon on the quantitative and qualitative characteristics of the labor potential and the possibilities of its use. Our assessment of the number of internally displaced persons (IDPs), and our examination of the state of their adaptation and integration in the new territories of residence are based on administrative data about the registration of citizens as IDPs provided by social services as well as the surveys and research findings by international organizations and domestic sociological institutions. We present an overview of individual challenges and risks raised by the forced displacement of the population, and highlight the specific features of their manifestation. In particular, we single out an increase in the demographic burden, a decrease in the number of people of reproductive age, a reduction in the number of jobs, an increase in the burden on the budget, a drop in labor productivity, a loss or reduction in the income of a large part of the population, a limit of access to quality social services, as well as unemployment, deterioration of the quality of employment, increased social vulnerability, and weakening of social cohesion. Risks increase the probability of negative changes that lead to uncertainty, deterioration of the demographic situation, weakening of the stability of the economy, decline in the level and quality of life of the population, deepening of social inequality, growth of social tension, decline in the consumption capacity of the population, complete or partial loss of social ties and jobs. We offer recommendations regarding priorities and specific measures of the national state policy aimed at avoiding risks and minimizing their possible consequences. The implementation of this policy should be focused on establishing legal, economic, and institutional frameworks for easing tensions in the areas of material security and employment, improving the demographic situation as well as the quality and availability of social services, and improving living conditions.