bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanofiber-Based Drug Delivery Systems: A Review on Its Applications, Challenges, and Envisioning Future Perspectives
Authors: Alfadhel Munerah 
Published: September 2024

Abstract:
Nanomaterials, especially nanofibers, hold considerable promise as drug delivery systems
(DDS) by providing targeted administration of drugs due to their unique properties, such as
large surface area, high porosity, and mechanical robustness. Nanofibers can be fabricated using
various techniques like electrospinning, self-assembly, phase separation, and template synthesis,
offering properties such as adjustable size, shape, high precision, and biodegradability. Additionally,
features such as multiple target functionalization, controlled release of the drug, and prolonged
circulation of the drug make nanofibers particularly suitable for biomedical applications, including
drug delivery, tissue regeneration, and biosensing. This comprehensive review explores the
characteristics, types, fabrication methods, and applications of nanofibers. Diverse types of polymer
nanofibers are used in drug delivery, such as blended nanofibers, core-shell nanofibers, and
layer-by-layer assembly, each demonstrating their own advantages in controlled drug release and
targeted therapy. Electrospun nanofibers are extensively utilized in biomedical applications due to
their superior mechanical performance and high porosity and advancements in coaxial electrospinning
enabling the fabrication of core-shell nanofibers, offering controlled drug release kinetics and
protection of loaded molecules. These nanofibers demonstrate enhanced bioactivity and biocompatibility
and can find application in tissue engineering. Furthermore, this review addresses the
challenges associated with nanofiber production, including reproducibility and scalability. Nanofibers
exhibit the potential to revolutionize medical treatment across diverse therapeutic areas. Future
research directions and challenges in nanofiber-based drug delivery discussed in this review
offer guidance for further advancements in this rapidly evolving field.
Carya Illinoinensis-mediated Green Synthesis and Antimicrobial Screening of Zirconium Oxide Nanoparticles: The Promising Antimicrobial Agent
Authors: Rehman Wajid , Rehman Asra , Rasheed Liaqat , Hussain Rafaqat , Iqbal Shahid , Saboor Abdul , AlAsmari Abdullah F. , Alasmari Fawaz , Khan Momin 
Published: September 2024

Background:
The synthesis of metal-based nanoparticles through conventional methods
involves harsh conditions, high costs, and severe environmental threats. To overcome these issues,
researchers are nowadays focusing on eco-friendly and low-cost methods for the synthesis of nanoparticles.
Finally, several plant-mediated synthesis techniques have been developed, which have
various advantages, such as low-cost, environmentally friendly, and easy application. The plant extract
not only serves as a reducing agent but also plays a role as a stabilizing agent. The plantmediated
synthesis provides new opportunities for cost-effective, environmentally-friendly nanoparticle
synthesis with high dispersity and stability. Besides, bio-generated nanoparticles derived from
plant extract have promising pharmacological applications, making them potential candidates for
future medicines.

Aims and Objectives:
The current study aimed to synthesize zirconium oxide nanoparticles using
Carya illinoinensis extract and examine their physicochemical properties. Additionally, the antimicrobial
efficacy of these nanoparticles was evaluated against various pathogens, exploring their potential
as potent antimicrobial agents.

Methods:
The synthesized nanoparticles were analyzed and characterized by various techniques like
UV-Vis spectroscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy
(TEM), and Energy Dispersive X-ray spectroscopy (EDX). The UV-visible peak at 216 nm confirmed
the formation of ZrO2 nanoparticles. The SEM images clearly showed that nanoparticles were
spherical and relatively dispersed, with few agglomerations. The EDX spectra confirmed the existence
of zirconium and oxygen as the basic constituents of the sample. TEM images demonstrated
nanoparticles as spherical and uniformly dispersed but agglomerated with increasing precursor concentrations
and decreasing nanoparticle dispersion. Fluconazole and gentamicin were used as standards
in determining the antibacterial and antifungal activities of nanoparticles.

Results:
Considering the antifungal activity, a maximum zone of inhibition of 16 μg/ml was demonstrated
in the case of 2 mM as compared to 4 mM and 6 mM concentrations. The Carya illinoinensismediated
ZrO2 nanoparticles were screened against Gram-positive (S. aureus and P. aeruginosa) and
Gram-negative (S. typhi and E. coli) bacterial strains. The fabricated nanoparticles exhibited promising
action against all microorganisms.

Conclusion:
In the current study, zirconium oxide nanoparticles were synthesized by using Carya
illinoinensis leaves extract as a reducing agent. The antifungal and antibacterial potential of the synthesized
nanoparticles were evaluated. The green synthesis method used in this study is preferable to
the others as it is more affordable, environmentally benign, and widely accessible.
Practical Way to Use Supraglottic Airway Device
Authors: Dell’Orto Valentina Giovanna , Beretta Virginia , Petrolini Chiara , Perrone Serafina 
Published: September 2024

Abstract:
We read a review of case reports published on Current Pediatric Reviews 2024 about
the use of I-gel® in neonatal complicated intubation, and we decided to write a commentary on the
benefits and limitations of using supraglottic airways in neonatal age, with a specific focus on Igel
[1]. The use of supraglottic airway devices in neonatal ages is limited to particular conditions,
but further research is showing the utility of these devices as the first choice in neonatal resuscitation
or airway stabilization. Our commentary highlights the broader practical applications of I-gel
and reinforces its role as a valuable tool in neonatal resuscitation.
Sexual Dysfunction in Women with Asthma and Associated Factors
Authors: Ozkarafakili Mufide A. , Turkmen Nihat 
Published: September 2024

Background:
Asthma is a common chronic inflammatory airway disease. Female sexual
dysfunction (FSD) is frequently seen in asthmatics but often unnoticed in clinical practice. This
study evaluated the associations between asthma disease characteristics and (FSD).

Methods:
A total of 73 female asthma patients who visited the chest department outpatient clinic
and age-matched 73 healthy controls were enrolled. All the participants completed the questionnaires:
female sexual function index (FSFI), BECK depression, and BECK anxiety inventory, and
underwent pulmonary function tests. Patients with asthma completed an asthma quality of life
questionnaire (AQLQ) and asthma control test (ACT). FSD risk factors were analyzed using logistic
regression analysis.

Results:
About 68.8% of asthmatics had female sexual dysfunction. BECK anxiety and FSFI
scores with all six subsets were statistically significantly lower than healthy individuals in asthmatics
(p < 0.001). CRP levels, BECK anxiety, and depression scores had inverse (r = -0.386 r =
-0.343 r = -0.286), and FEV1% had a positive correlation with FSFI total scores. About 37.5% of
asthma patients with FSD were current smokers, the most compromised domain of the FSFI scale
was sexual arousal with a mean of 2.94 ± 0.56 and their FEV1% was lower, and CRP was higher
than the asthma patients without FSD (p < 0.001, p < 0.021). Smoking, high levels of CRP and
BECK anxiety scores, and low FEV1% were found to be risk factors for FSD in regression analysis.

Conclusions:
Female sexual dysfunction is frequently present in asthma patients. Smokers, patients
who have anxiety, lower FEV1% predicted values, and higher CRP levels tend to be susceptible
to sexual dysfunction, which implicates inflammation as an underlying mechanism.
Exploring Quinoline Derivatives: Their Antimalarial Efficacy and Structural Features
Authors: Mishra Raghav , da Cunha Xavier Jayze , Kumar Nitin , Krishna Gaurav , Dhakad Prashant Kumar , dos Santos Helcio Silva , Bandeira Paulo Nogueira , Rodrigues Tigressa Helena Soares , Gondim Diego Romao , Ribeiro Walber Henrique Ferreira , da Silva Draulio Sales , Teixeira Alexandre Magno Rodrigues , Pereira Wandresa Francelino , Marinho Emmanuel Silva , Sucheta  
Published: September 2024

Objectives:
Malaria continues to be the primary cause of mortality worldwide, and timely
recognition and prompt intervention are crucial in mitigating adverse consequences. This review
article aims to examine the effectiveness and structural characteristics of quinoline-based compounds
as antimalarial agents. It specifically focuses on their therapeutic effects as well as potential
prospects for exploring structure-activity relationship (SAR). In addition, this study aims to identify
lead compounds that can efficiently battle multidrug-resistant forms of Plasmodium falciparum and
Plasmodium vivax.

Methods:
A comprehensive review was conducted to evaluate the effectiveness of quinoline-based
antimalarial medications in eradicating P. falciparum and P. vivax. The mechanism of action and
SAR of these compounds were analyzed

Results:
Quinoline-based antimalarials demonstrated significant effectiveness in eliminating P.
falciparum parasites, particularly in regions severely impacted by malaria, including Africa and
Asia. These compounds were found to exhibit tolerance and immune-modulating properties, indicating
their potential for more widespread utilization. The investigation identified various new
quinoline compounds with improved antimalarial activity, including metal-chloroquine complexes,
diaminealkyne chloroquines, and cinnamoylated chloroquine hybrids. This study explored different
mechanisms by which these compounds interact with parasites, including their ability to accumulate
in the parasite’s acidic food vacuoles and disrupt heme detoxification. The derivatives demonstrated
strong efficacy against chloroquine-resistant strains and yielded positive results.

Conclusion:
Quinoline-based compounds represent a promising avenue for combating malaria due
to their demonstrated efficacy against P. falciparum and P. vivax parasites. Further research on
their mechanisms of action and SAR could lead to the development of more effective antimalarial
medications.
Unraveling the Mysteries of PCOS: A Comprehensive Investigation into Causes, Mechanisms, and Molecular Docking Analysis with Dolichos biflorus Linn.
Authors: Sharma Priyanshu , Mittal Payal , Arya Girish Chandra 
Published: September 2024

Abstract:
Polycystic ovary syndrome (PCOS) presents as a complex endocrine and metabolic disorder
characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Various
factors contribute to PCOS risk, including lifestyle choices, diet, environmental pollutants, genetics,
gut dysbiosis, neuroendocrine changes, and obesity. These factors can impact hyperinsulinemia,
oxidative stress, hyperandrogenism, decreased folliculogenesis, and irregular menstrual cycles,
ultimately contributing to metabolic syndrome. Conventional treatments for PCOS often carry significant
side effects, prompting exploration into Ayurvedic alternatives. This review concentrates on
molecular docking studies of phytochemicals sourced from Dolichos Biflorus Linn. against key proteins
implicated in PCOS pathogenesis. Identification, modeling, and evaluation of target proteins
were conducted, followed by the assessment of their interactions with selected phytochemicals and
additional ADMET analysis. Molecular docking studies utilizing Auto Dock Vina software were
then performed to forecast the binding affinities of these phytochemicals to the active sites of the
specified targets.
Aptamer-based Strategies for COVID-19 Detection and Treatment: A Systematic Review Study
Authors: Nakhaie Mohsen , Ghoreshi Zohreh-al-sadat , Charostad Javad , Salajegheh Faranak , Rezaei Zadeh Rukerd Mohammad , Arefinia Nasir 
Published: September 2024

Background:
Aptamer-based strategies have emerged as promising tools for the detection
and treatment of COVID-19, offering advantages such as high specificity, sensitivity, and versatility.
This systematic review aims to evaluate the effectiveness and innovation of aptamer-based approaches
for COVID-19 detection and treatment.

Methods:
Following the guidelines of the Cochrane Handbook for Systematic Reviews and the
PRISMA 2020 guidelines, a systematic search was conducted across multiple databases up to 2024.
The search included studies that utilized aptamers for the diagnosis or therapy of COVID-19. Screening
and selection of studies were performed independently by two reviewers, with any disagreements
resolved by a third reviewer. Data were extracted regarding study characteristics, aptamer details,
and outcomes.

Results:
In our systematic review, 98 studies from an initial pool of 1541 records met the inclusion
criteria for analysis. Aptamers, single-stranded DNA or RNA molecules with unique threedimensional
(3D) structures, were extensively explored for COVID-19 detection and treatment. Various
aptamer-based assays, including electrochemical sensors, surface plasmon resonance (SPR)
biosensors, and lateral flow assays, demonstrated high sensitivity and specificity in detecting SARSCoV-
2 in clinical samples such as saliva, nasal swabs, and wastewater. Several aptamer structures
targeting viral proteins like the spike and nucleocapsid proteins were employed. Nucleic Acid Amplification
Techniques (NAATs) utilizing aptamers, such as Clustered Regularly Interspaced Short
Palindromic Repeats (CRISPR)-based and Loop-mediated Isothermal Amplification (LAMP) assays,
showed exceptional sensitivity in detecting viral genetic material. Aptamer-based therapeutic approaches
showed potential by blocking viral protein activity or serving as delivery vehicles for therapeutic
agents like small interfering RNAs (siRNAs). Despite their advantages, aptamer technologies
face limitations such as susceptibility to nuclease degradation and rapid renal clearance, highlighting
the need for further optimization.

Conclusion:
Aptamer-based strategies present promising avenues for COVID-19 detection and treatment.
These approaches offer advantages such as high sensitivity, specificity, and rapid detection, making
them valuable tools in combating the COVID-19 pandemic. Further research and development are
warranted to optimize aptamer-based strategies for widespread application in clinical settings.
Preparation, Characterization and Sustained-release Study of Encapsulated Cinnamon Essential Oil Microcapsules
Authors: Haputhanthri Rukshani , Dehigahawatta Sajini , Sandaruwan Chanaka , Perera Kasuni Kanchanamali , Pieris Colin 
Published: September 2024

Aims:
The aim of this study is to study preparation, characterization and sustained release
of Encapsulated Cinnamon Essential Oil Microcapsules.

Background:
In this work, encapsulated cinnamon essential oil (CEO) microcapsules were prepared,
characterized, and analyzed for their sustained-release properties. CEO microcapsules were encapsulated
from an alginate polymer using homogenization and extrusion, and the encapsulation mechanism
used was ionic gelation. The potent antibacterial properties of natural cinnamon oil extracts and
their shelf-life activity can be reduced or eliminated as a result of deterioration caused by light, heat,
and oxygen exposure during production. High-speed homogenization was utilized for the encapsulation,
which encloses and protects the volatile compounds from degradation.

Objective:
The objective of this study is to synthesize sustained-release encapsulated cinnamon essential
oil (CEO) microcapsules.

Method:
The preparation of encapsulated cinnamon oil was achieved through homogenization. The
extrusion method was employed to obtain microcapsules encapsulating liquid active ingredients (AI)
with alginate polymer to induce ionic gelation.

Results:
SEM and Optical images reveal that all microcapsules maintain their spherical shape with
clearly defined membranes. XPS analysis indicates the presence of oxygen (O), carbon (C), and sodium
(Na) on the surface, suggesting the presence of an alginate-based ionic gelation. Chromatographic
studies demonstrate a high encapsulation efficiency of 99%. The average microcapsule size
is 261.5 nm for the fresh sample and 278 nm after 3.5 months. The zeta potential is -29.8 mV for the
fresh sample and -28.2 mV after 3.5 months. Notably, there is no evidence of microcapsule agglomeration
during the 3.5-month storage period as observed in the study. TGA data reveals that only
7.5% of the adsorbed water and essential oil mixture is lost at 40°C over 4 hours, in contrast to
11.7% for the adsorbed water material, indicating a sustained release of the encapsulated CEO from
the microcapsules.

Conclusion:
The microcapsules exhibited an impressive encapsulation efficiency of 99%, demonstrating
stability over the 3.5-month investigation period and showcasing sustained-release properties.
Pengaruh Perencanaan Keuangan, Literasi Keuangan, Dan Pendapatan Terhadap Pengelolaan Keuangan
Authors: Gusti Marchella An , Juwita Himmiyatul Amanah Jiwa 
Published: September 2024

The objective of this research is to identify the effects of financial planning, financial literacy, and income on financial management. The research objects are civil servant teachers of Sijunjung Regency. This explanatory research elucidates the casual relationship between its dependent and independent variables using quantitative approach. The data of this research was harvested via closed 5-point Likert-scaled questionnaires distributed to 93 respondents, which were selected using proportionate stratified random sampling. The analysis as performed in IBM SPSS Statistics version 25 using multiple linear regression. This study finds that financial planning, financial literacy, and income significantly influence financial management. Therefore, it is crucial to increase the awareness of the civil servant teachers about the importance of financial management.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh perencanaan keuangan, literasi keuangan, dan pendapatan terhadap pengelolaan keuangan. Objek penelitian yang digunakan yaitu Guru PNS di Kabupaten Sijunjung. Penelitian ini merupakan explanatory research yang menjelaskan hubungan kausal antar variabel dependen dan independen melalui pendekatan kuantitatif. Metode pengumpulan data dilakukan dengan penyebaran kuesioner tertutup menggunakan skala pengukuran likert lima poin. Pengambilan sampel dilakukan dengan metode proportionate stratified random sampling. Sampel yang digunakan pada penelitian ini berjumlah 93 responden. Data diolah dengan menggunakan metode analisis regresi linear berganda dengan software SPSS IBM Statistic versi 25. Hasil penelitian menunjukkan bahwa perencanaan keuangan, literasi keuangan, dan pendapatan berpengaruh secara signifikan terhadap pengelolaan keuangan. Implikasi dari penelitian ini adalah meningkatkan kesadaran Guru PNS akan pentingnya pengelolaan keuangan.
Normative data for inferior vena cava diameter and its correlation with age, sex and somatic parameters in Indian children
Authors: Sreenivasan Vismaya , Rangasamy K. , Eldow Arun joe 
Published: September 2024

Background. India, a significant contributor to global childbirth, faces the challenge of childhood mortality. Despite progress, diarrhoea-induced dehydration remains a pressing concern, contributing to 13 % of child mortality in the country. This study aims to assess the utility of point-of-care ultrasonography in evaluating intravascular volume status in paediatric patients, especially those experiencing dehydration. The lack of normative data on inferior vena cava (IVC) diameter in Indian children prompted conducting this study. Materials and methods. It was a prospective observational study performed at Vinayaka Mission’s Kirupananda Variyar Medical College in Salem, Tamil Nadu for 1 year. Data from 200 outpatient children aged 2 to 12 were analysed to establish normative IVC diameter and explore correlations with age, gender, and somatic characteristics. Statistical analyses employed SPSS software, presenting quantitative data as mean and standard deviations and qualitative data as percentages. Results. This study enrolled 52 % females and 48 % males. Results showed the mean IVC volume of 8.650 ± 2.325 mm with a minimum of 5 mm to a maximum of 15 mm. Correlation tests assessed associations between variables, setting significance at p < 0.05. Results highlighted IVC dimensions in Indian children, demonstrating associations between age, height, weight, and abdominal girth with IVC diameter. Conclusions. This study provides a normative data for IVC diameter in Indian children, elucidating its associations with age and somatic characteristics. The findings underscore the importance of IVC measurements when evaluating dehydration levels, highlighting the necessity for further research with larger sample size thereby enhancing clinical precision and applicability.
Post-COVID syndrome in pediatric practice: data from literature and clinical case
Authors: Iskiv M.Yu. , Lukyanenko N.S. , Kech N.R. , Chaykovska H.S. 
Published: September 2024

Background. An urgent and problematic issue in medicine today, in addition to the acute manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, are the consequences of coronavirus disease 2019 (COVID-19), the so-called post-COVID syndrome (PCS). Currently, leading medical research institutions around the world are studying the causes, frequency and symptoms of PCS in both adults and children. Aim: to review the literature on the incidence and manifestations of post-COVID syndrome in children in order to draw the attention of medical professionals to the problem of post-COVID syndrome and its symptoms from various body systems. Materials and ­methods. The literature search was conducted in the PubMed and Google Scholar databases using the following keywords: “SARS-CoV-2 or COVID-19” and “post-COVID”, “long COVID”, “diabetes mellitus” and “in children”. Ukrainian literature search was conducted in the Google Scholar database using the following keywords: “SARS-CoV-2 or COVID-19” and “post-COVID”, “diabetes mellitus” and “in children”. The authors of the article reviewed the titles and abstracts of the found articles to select relevant publications. ­Results. The article provides data from the literature on PCS in children: definition of post-COVID syndrome in children, incidence, possible causes, pathogenesis and risk factors for the development of PCS. Signs of somatic, psychological and endocrinological manifestations of PCS are also given. The greatest attention is paid to the onset of type 1 diabetes mellitus (T1DM) in children after suffering ­COVID-19. It is noted that the frequency of T1DM in the pediatric population in the post-COVID period has almost doubled, to 0.043 versus 0.025 %. Global rate of new cases of T1DM in children in 2020 grew to 32.39 per 100,000 children compared to 19.73 per 100,000 children in 2019. Probable causes of diabetes after ­COVID-19 are direct cytolysis of pancreatic β-cells affected by the virus, and autoimmune reaction. A clinical case of diabetes mellitus in a young child as a possible manifestation of the PCS is provided. Conclusions. 1. The problem of PCS with various clinical manifestations in children is relevant and quite common. 2. PCS can deve­lop not only in children with acute manifestations of COVID-19, but also in children with asymptomatic course. 3. Along with the most frequent somatic and psychological manifestations of COVID-19 in children, endocrinopathy may occur, such as diabetes mellitus.