bluuebunny/crossref_metadata_2025_split huggingface dataset:
Job satisfaction in African public administrations: a systematic review
Authors: Vigan Fanou Arsène , Giauque David 
Published: September 2016

In this study, we present a review of public agents’ job satisfaction in Africa between 1990 and 2014. Using the systematic review methodology, we analyse and put in perspective 22 English and French publications on this subject. Results suggest that work environment attributes are the most important antecedents of job satisfaction among African public servants, whereas the effects of personal and work characteristics are marginal. We also found that most of the research dedicated to job satisfaction in Africa relied primarily on theoretical frameworks developed in Western countries. This leads to unexpected results, indicating the need to fit the research models to local specificities. The consequences of job satisfaction in Africa and suggestions for future research are also discussed. Points for practitioners This contribution allows practitioners to obtain an overview of the factors that promote the satisfaction/dissatisfaction of public sector employees in Africa. It helps them identify factors on which to act for the implementation of effective personnel policies geared towards the officials’ performance and welfare. The results suggest paying attention to factors related to the working environment (such as the atmosphere at work, organisational support and working conditions) in order to enhance effectively job satisfaction in African public organisations. However, practices such as the establishment of clear objectives and procedures, autonomy, work content, and the recognition of effort are not to be overlooked.
Financial and legal decision-making capacity in the aphasic population – a narrative review
Authors: Carr Frances 
Published: September 2016

Introduction Capacity is assumed to be present unless proven otherwise. Assessments of specific decision-making capacity for financial and legal decisions, although challenging in the general population, becomes almost impossible for individuals with language disorders (i.e. aphasia) in the absence of appropriate communication aids. Several capacity aids exist for the general population; however, it is unclear whether any communication aids exist specifically for the aphasic population to assist assessment of financial and legal decision-making capacity. Method A literature review was conducted of six databases with the assistance of a research librarian. From 171 articles screened, 12 were included in the final review. Results The literature focus was on medical decision-making capacity, and in particular, patient consent. Few articles addressed legal or financial decision-making capacity. Several articles identified the presence of general and specific capacity aids for the general population; however, there was a clear absence of similar communication aids available for the aphasic population with only one communication aid identified to assist with decision-making capacity assessment for healthcare and accommodation decisions only. Conclusion Whilst a significant amount of research has been done on decision-making capacity, it is mostly focused on healthcare; in particular, on patient consent for treatment for the non-aphasic population. Although a communication aid exists to aid assessment of decision-making capacity for healthcare for aphasic individuals, no similar tools exist to aid financial and legal decision-making capacity assessments. This paper highlights an important problem encountered during clinical practice which requires further research.
Stiff Landings Are Associated With Increased ACL Injury Risk in Young Female Basketball and Floorball Players
Authors: Leppänen Mari , Pasanen Kati , Kujala Urho M. , Vasankari Tommi , Kannus Pekka , Äyrämö Sami , Krosshaug Tron , Bahr Roald , Avela Janne , Perttunen Jarmo , Parkkari Jari 
Published: September 2016

Background: Few prospective studies have investigated the biomechanical risk factors of anterior cruciate ligament (ACL) injury. Purpose: To investigate the relationship between biomechanical characteristics of vertical drop jump (VDJ) performance and the risk of ACL injury in young female basketball and floorball players. Study Design: Cohort study; Level of evidence, 3. Methods: At baseline, a total of 171 female basketball and floorball players (age range, 12-21 years) participated in a VDJ test using 3-dimensional motion analysis. The following biomechanical variables were analyzed: (1) knee valgus angle at initial contact (IC), (2) peak knee abduction moment, (3) knee flexion angle at IC, (4) peak knee flexion angle, (5) peak vertical ground-reaction force (vGRF), and (6) medial knee displacement. All new ACL injuries, as well as match and training exposure, were then recorded for 1 to 3 years. Cox regression models were used to calculate hazard ratios (HRs) and 95% CIs. Results: Fifteen new ACL injuries occurred during the study period (0.2 injuries/1000 player-hours). Of the 6 factors considered, lower peak knee flexion angle (HR for each 10° increase in knee flexion angle, 0.55; 95% CI, 0.34-0.88) and higher peak vGRF (HR for each 100-N increase in vGRF, 1.26; 95% CI, 1.09-1.45) were the only factors associated with increased risk of ACL injury. A receiver operating characteristic (ROC) curve analysis showed an area under the curve of 0.6 for peak knee flexion and 0.7 for vGRF, indicating a failed-to-fair combined sensitivity and specificity of the test. Conclusions: Stiff landings, with less knee flexion and greater vGRF, in a VDJ test were associated with increased risk of ACL injury among young female basketball and floorball players. However, although 2 factors (decreased peak knee flexion and increased vGRF) had significant associations with ACL injury risk, the ROC curve analyses revealed that these variables cannot be used for screening of athletes.
Measurement and assessment of out-of-round electric locomotive wheels
Authors: Tao Gongquan , Wang Linfeng , Wen Zefeng , Guan Qinghua , Jin Xuesong 
Published: September 2016

This paper presents a detailed investigation of out-of-round electric locomotive wheels through extensive measurement conducted at field sites. More than 2000 wheels, of seven types of locomotives widely used in China, have been measured since April 2013. The measurement results indicate that two types of freight traffic locomotives suffer serious polygonal wear problems with center wavelengths ranging from 160 to 315 mm. The dominating wavelength is 200 mm. Therefore, the investigations are mainly focused on the two locomotive types. The other types, which are taken for comparison, do not exhibit obvious polygonal wear. However, they exhibited more or less eccentricity. The effect of wheel re-profiling on the wheel polygon is also investigated and discussed. The dominating harmonic orders and center wavelengths after re-profiling are consistent with those before re-profiling at the correct circumstances, if the center wavelength of the polygonal wear is about 200 mm.
Progenitor cell secretory products exert additive renoprotective effects when combined with ace inhibitors in experimental CKD
Authors: Kepecs David M , Yuen Darren A , Zhang Yanling , Thai Kerri , Connelly Kim A , Gilbert Richard E 
Published: September 2016

Hypothesis/introduction: Renal fibrovascular injury often persists in chronic kidney disease patients treated with renin-angiotensin system blockers. Intriguingly, early outgrowth cell-derived factor infusion also inhibits chronic renal injury. We sought to determine whether early outgrowth cell-derived factor administration provides further renoprotection when added to renin-angiotensin system blockade. Materials and methods: Conditioned medium was generated by incubating rat early outgrowth cells with serum-free endothelial basal medium-2 to collect their secreted factors. Subtotal nephrectomy rats received enalapril 0.5 mg/L in drinking water or placebo, beginning 8 weeks post-surgery. Four weeks later, enalapril-treated rats received intravenous injections of either conditioned medium or control endothelial basal medium-2 for 2 weeks. Glomerular filtration rate, urinary protein excretion and renal structure were assessed 4 weeks later at 16 weeks post-surgery. Results: Enalapril-treated subtotal nephrectomy rats receiving control endothelial basal medium-2 injections experienced only partial renoprotection when compared to vehicle-treated subtotal nephrectomy rats. In contrast, conditioned medium infusion, when administered in addition to enalapril, attenuated the progression of renal dysfunction in subtotal nephrectomy rats, improving glomerular filtration rate and reducing proteinuria without affecting blood pressure. Conclusions: Early outgrowth cell-derived factors exert additive renoprotective effects on top of angiotensin-converting enzyme inhibitor therapy in experimental chronic kidney disease, providing the rationale for clinical trials of early outgrowth cell-based therapies for chronic kidney disease.
Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2–HO-1 pathway in renal proximal tubular cells of transgenic mice
Authors: Chang Shiao-Ying , Lo Chao-Sheng , Zhao Xin-Ping , Liao Min-Chun , Chenier Isabelle , Bouley Richard , Ingelfinger Julie R , Chan John SD , Zhang Shao-Ling 
Published: September 2016

Introduction: We aimed to examine the regulation of aquaporin 1 expression in an angiotensinogen transgenic mouse model, focusing on underlying mechanisms. Methods: Male transgenic mice overexpressing rat angiotensinogen in their renal proximal tubular cells (RPTCs) and rat immortalised RPTCs stably transfected with rat angiotensinogen cDNA were used. Results: Angiotensinogen-transgenic mice developed hypertension and nephropathy, changes that were either partially or completely attenuated by treatment with losartan or dual renin–angiotensin system blockade (losartan and perindopril), respectively, while hydralazine prevented hypertension but not nephropathy. Decreased expression of aquaporin 1 and heme oxygenase-1 and increased expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and sodium–hydrogen exchanger 3 were observed in RPTCs of angiotensinogen-transgenic mice and in angiotensinogen-transfected immortalised RPTCs. These parameters were normalised by dual renin–angiotensin system blockade. Both in vivo and in vitro studies identified a novel mechanism in which angiotensinogen overexpression in RPTCs enhances the cytosolic accumulation of Nrf2 via the phosphorylation of pGSK3β Y216. Consequently, lower intranuclear Nrf2 levels are less efficient to trigger heme oxygenase-1 expression as a defence mechanism, which subsequently diminishes aquaporin 1 expression in RPTCs. Conclusions: Angiotensinogen-mediated downregulation of aquaporin 1 and Nrf2 signalling may play an important role in intrarenal renin–angiotensin system-induced hypertension and kidney injury.
Ultrasound-guided alcohol neurolysis of lateral femoral cutaneous nerve for intractable meralgia paresthetica: a case series
Authors: Ahmed Arif , Arora Divesh , Kochhar Amit Kumar 
Published: September 2016

Meralgia paresthetica is a rare sensory entrapment neuropathy which leads to burning, tingling and numbness in the antero-lateral aspect of thigh. Mostly it runs a benign course, and responds to conservative measures. We present a case series of six patients with intractable meralgia paresthetica with severe pain over antero-lateral thigh along the distribution of lateral cutaneous nerve of thigh which was further confirmed by nerve conduction study. These patients did not respond to the oral anti-neuropathic medications. The two successive diagnostic lateral femoral cutaneous nerve block not only had confirmed the diagnosis but also provided pain relief for a few days. Then the ultrasound-guided lateral femoral cutaneous nerve neurolysis was done using 50% alcohol. In all the patients, there were more than 50% decrease in pain intensity and improvement in quality of life after the procedure, and the relief and improvement were maintained for up to 12 weeks. This case series shows ultrasound-guided lateral femoral cutaneous nerve neurolysis is a safe and effective treatment for intractable meralgia paresthetica and also provides prolonged pain relief and is a good option in avoiding the surgery. Summary points The literature on neurolysis is rare, with only few case reports. This is the first case series on this topic, and it will greatly improve the evidence that ultrasound-guided neurolysis can also be used for intractable meralgia paresthetica patients who do not respond to conservative measures before proceeding to surgery.
nbCNV: a multi-constrained optimization model for discovering copy number variants in single-cell sequencing data
Authors: Zhang Changsheng , Cai Hongmin , Huang Jingying , Song Yan 
Published: September 2016

Abstract
Background
Variations in DNA copy number have an important contribution to the development of several diseases, including autism, schizophrenia and cancer. Single-cell sequencing technology allows the dissection of genomic heterogeneity at the single-cell level, thereby providing important evolutionary information about cancer cells. In contrast to traditional bulk sequencing, single-cell sequencing requires the amplification of the whole genome of a single cell to accumulate enough samples for sequencing. However, the amplification process inevitably introduces amplification bias, resulting in an over-dispersing portion of the sequencing data. Recent study has manifested that the over-dispersed portion of the single-cell sequencing data could be well modelled by negative binomial distributions.

Results
We developed a read-depth based method, nbCNV to detect the copy number variants (CNVs). The nbCNV method uses two constraints-sparsity and smoothness to fit the CNV patterns under the assumption that the read signals are negatively binomially distributed. The problem of CNV detection was formulated as a quadratic optimization problem, and was solved by an efficient numerical solution based on the classical alternating direction minimization method.

Conclusions
Extensive experiments to compare nbCNV with existing benchmark models were conducted on both simulated data and empirical single-cell sequencing data. The results of those experiments demonstrate that nbCNV achieves superior performance and high robustness for the detection of CNVs in single-cell sequencing data.
Genome sequence of Candidatus Arsenophonus lipopteni, the exclusive symbiont of a blood sucking fly Lipoptena cervi (Diptera: Hippoboscidae)
Authors: Nováková Eva , Hypša Václav , Nguyen Petr , Husník Filip , Darby Alistair C. 
Published: September 2016

AbstractCandidatus Arsenophonus lipopteni (Enterobacteriaceae, Gammaproteobacteria) is an obligate intracellular symbiont of the blood feeding deer ked, Lipoptena cervi (Diptera: Hippoboscidae). The bacteria reside in specialized cells derived from host gut epithelia (bacteriocytes) forming a compact symbiotic organ (bacteriome). Compared to the closely related complex symbiotic system in the sheep ked, involving four bacterial species, Lipoptena cervi appears to maintain its symbiosis exclusively with Ca. Arsenophonus lipopteni. The genome of 836,724 bp and 24.8 % GC content codes for 667 predicted functional genes and bears the common characteristics of sequence economization coupled with obligate host-dependent lifestyle, e.g. reduced number of RNA genes along with the rRNA operon split, and strongly reduced metabolic capacity. Particularly, biosynthetic capacity for B vitamins possibly supplementing the host diet is highly compromised in Ca. Arsenophonus lipopteni. The gene sets are complete only for riboflavin (B2), pyridoxine (B6) and biotin (B7) implying the content of some B vitamins, e.g. thiamin, in the deer blood might be sufficient for the insect metabolic needs. The phylogenetic position within the spectrum of known Arsenophonus genomes and fundamental genomic features of Ca. Arsenophonus lipopteni indicate the obligate character of this symbiosis and its independent origin within Hippoboscidae.
Does Propofol Anesthesia Lead to Less Postoperative Pain Compared With Inhalational Anesthesia?: A Systematic Review and Meta-analysis
Authors: Peng Ke , Liu Hua-Yue , Wu Shao-Ru , Liu Hong , Zhang Zhao-Cai , Ji Fu-Hai 
Published: September 2016

BACKGROUND:
Many studies have compared propofol-based anesthesia with inhalational anesthesia. Results from several studies have shown improved postoperative analgesia after propofol anesthesia, but other studies showed contradictory results. There are no large prospective studies that compare postoperative pain after propofol versus inhalational anesthesia. This meta-analysis was designed to focus on this question.

METHODS:
A systematic literature search for randomized controlled trials that compared propofol-based anesthesia with volatile agents-based anesthesia in adults undergoing surgery was conducted. Published data were pooled for the meta-analysis with Review Manager (ie, RevMan). The main outcomes included postoperative pain intensity, opioid consumption, need for rescue analgesics, and time to first analgesia.

RESULTS:
Thirty-nine clinical trials with a combined subject population of 4520 patients came within the purview of this meta-analysis. The investigated volatile agents included isoflurane, sevoflurane, and desflurane. Compared with inhalational anesthetics, the propofol use was associated with a reduced postoperative pain intensity at rest at 30 minutes, 1 hour, and 12 hours (mean difference in pain scores, 30 minutes, −0.48 [visual analog scale, 0–10]; 99% confidence interval [CI], −1.07 to 0.12, P = 0.04) and reduced morphine-equivalent consumption 0 to 24 hours postoperatively (mean difference in morphine-equivalent consumption, −2.68 mg; 99% CI, −6.17 to 0.82; P = 0.05). Fewer patients required postoperative rescue analgesics during 0 to 24 hours after surgery under propofol anesthesia (risk ratio, 0.87; 99% CI, 0.74–1.03; P = 0.04). In addition, patients anesthetized with propofol required administration of postoperative analgesia later than those anesthetized with volatiles (mean difference in time to first analgesic administration, 6.12 minutes; 99% CI, 0.02–12.21; P = 0.01). Considering that Z statistic in RevMan 5.3 does not perform optimally in highly heterogeneous samples among groups or many combinations of groups with small sample sizes, a P value of <.01 was considered statistically significant. On the basis of this threshold, none of the aforementioned results are statistically significant.

CONCLUSIONS:
The current results are affected by substantial heterogeneity, which makes it difficult to predict significant differences in postoperative pain control between propofol anesthesia and inhalational anesthesia. Further large, randomized controlled trials are needed to corroborate these results and to detect differences (if any) between propofol and inhalational anesthesia on postoperative pain.
Metabolic Acidosis Assessment in High-Risk Surgeries: Prognostic Importance
Authors: Silva João Manoel , Ribas Rosa de Oliveira Amanda Maria , Mendes Nogueira Fernando Augusto , Vianna Pedro M. M. , Amendola Cristina Prata , Carvalho Carmona Maria José , Sá Malbouisson Luiz M. 
Published: September 2016

BACKGROUND:
Metabolic acidosis frequently is present in surgical patients; however, different types of metabolic acidosis (hyperlactatemia, hyperchloremia, and others) may have different relationships to perioperative outcomes. We hypothesized that in postoperative surgical patients, distinctive types of metabolic acidosis would correlate differently with the outcomes of high-risk surgeries.

METHODS:
A prospective, multicenter observational study was performed in 3 different tertiary care hospitals. Patients who required postoperative admission to the intensive care unit (ICU) were included in this study. Patients with a short life expectancy (those with untreated cancer and limited treatment), hepatic failure, renal failure, or a diagnosis of diabetes were excluded. Patients were classified at ICU admission according to the presence and type of metabolic acidosis into 4 groups: those without acidosis, those with a base excess <−4 mmol/L and albumin-corrected anion gap ≤12 mmol/L (hyperchloremic), those with a base excess <−4 mmol/L and increased albumin-corrected anion gap >12 mmol/L, and those with a base excess <−4 mmol/L and hyperlactatemia >2 mmol/L. Furthermore, patients were reclassified 12 hours after admission to the ICU to verify the metabolic acidosis behavior and outcome differences among the groups.

RESULTS:
The study included 618 patients. The incidence of acidosis at ICU admission was 59.1%; 23.9% presented with hyperchloremia, 21.3% with hyperlactatemia, 13.9% with increased anion gap, and 40.9% of the patients presented without metabolic acidosis. Patients whose metabolic acidosis persisted for 12 hours had an incidence of ICU complications rates in hyperlactatemia group of 68.8%, increased anion gap of 68.6%, hyperchloremic of 65.8%, and those without acidosis over 12 hours of 59.3%. A Cox regression model for postoperative 30-day mortality showed: in hyperlactatemic acidosis, hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.02–2.96; increased anion gap acidosis, HR = 1.68, 95% CI = 0.85–3.81; hyperchloremic acidosis, HR = 1.47, 95% CI = 0.75–2.89, and 10.3% of 30-day mortality rate in patients without acidosis. An adjusted survival curve by Cox regression found a worse 30-day survival in the hyperlactatemic group compared with the other groups (P = .03). Furthermore, in multiple comparisons among groups, patients with hyperlactatemic acidosis were more likely to develop renal dysfunction (P < .001) up to the seventh day postoperatively.

CONCLUSIONS:
We found that among patients with different types of acidosis, patients who developed hyperlactatemic metabolic acidosis postoperatively showed greater rates of renal dysfunction within 7 days and hyperlactatemic acidosis represented an independent factor on 30-day mortality in high-risk surgical patients.