bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Coupling Reactions of Zinc Amide Enolates with Nitriles: Preparation of β‐Keto and β‐Amino Amides.
Authors: Shin Ueon Sang , Joo Seong‐Ryu , Kim Seung‐Hoi 
Published: January 2016

AbstractCoupling of zinc amide enolates, generated in situ by direct addition of highly active zinc to N,N‐disubstituted chloroacetamides (I) or (V), with diverse aryl nitriles provides access to β‐enamino amides [cf.
ChemInform Abstract: A Novel Synthesis of 2,3‐Dihydro‐1,3‐methano‐1H‐indene {(Bicyclo[2.1.1]hexeno)benzene} and Analysis of Its NMR Spectra.
Authors: Christl Manfred , Cohrs Carsten 
Published: January 2016

AbstractA new route to title compound (VI) is developed.
ChemInform Abstract: Photocatalytic One‐Pot Synthesis of Homoallyl Ketones via a Norrish Type I Reaction of Cyclopentanones.
Authors: Okada Megumi , Yamada Keiichi , Fukuyama Takahide , Ravelli Davide , Fagnoni Maurizio , Ryu Ilhyong 
Published: January 2016

AbstractThe photocatalytic synthesis of homoallyl ketones is achieved via a one‐pot procedure starting from a Norrish Type I reaction of cyclopentanones, followed by a decatungstate‐catalyzed hydroacylation of electron‐deficient olefins by intermediate 4‐pentenals.
ChemInform Abstract: Enantioselective Functionalization of Inactive sp3 C—H Bonds Remote to Functional Group by Metal/Organo Cooperative Catalysis.
Authors: Zhou Xiao‐Le , Wang Pu‐Sheng , Zhang Da‐Wei , Liu Peng , Wang Cheng‐Ming , Gong Liu‐Zhu 
Published: January 2016

AbstractThe method serves for the [4 + 2]‐cyclization of aliphatic enolizable aldehydes with quinone derivatives in the presence of molecular oxygen as oxidant and a prolinol‐derived chiral catalyst.
ChemInform Abstract: Rhodium‐Catalyzed Direct Coupling of Benzothioamides with Alkenes and Alkynes Through Directed C—H Bond Cleavage.
Authors: Yokoyama Yuki , Unoh Yuto , Bohmann Rebekka Anna , Satoh Tetsuya , Hirano Koji , Bolm Carsten , Miura Masahiro 
Published: January 2016

AbstractRhodium‐catalyzed direct coupling of benzothioamides with alkenes and alkynes proceeds with ortho‐C—H bond cleavage.
ChemInform Abstract: Palladium‐Catalyzed Direct Arylation Using Free‐Amine‐Substituted Polyfluoroanilines with Inhibition of Amination‐Type Reaction.
Authors: Takfaoui Abdelilah , Touzani Rachid , Soule Jean‐Francois , Dixneuf Pierre H. , Doucet Henri 
Published: January 2016

AbstractFluoro‐substituted biphenyls bearing a free amine substituent are prepared without a protection/deprotection sequence.
ChemInform Abstract: Simple Method for sp2—sp3 and sp3—sp3 Carbon—Carbon Bond Activation in 2‐Substituted 1,3‐Diketones.
Authors: Aoyama Tadashi , et al.  
Published: January 2016

AbstractThe deacetylation (and debenzoylation) of 2‐substituted 1,3‐diketones is described by means of silica supported sulfuric acid and applied in one‐pot tandem bromination/deacylation reactions.
ChemInform Abstract: An Efficient Route to N‐Monosubstituted Guanidino‐Lactams.
Authors: Tommasi Sara , Zanato Chiara , Carabeo Rey , Mangoni Arduino A. , Dall'Angelo Sergio , Zanda Matteo 
Published: January 2016

AbstractThe preparation of a range of N‐alkyl substituted N,N′‐bis‐Boc‐pyrazole‐1H‐carboxamidines as guanylating agents from the corresponding alkyl alcohols is described which may contain various functional groups.
ChemInform Abstract: Pd(II)‐Catalyzed Formal [4 + 1] Cycloaddition Reactions of Diazoacetates and Aryl Propargyl Alcohols to Form 2,5‐Dihydrofurans.
Authors: Shi Taoda , Guo Xin , Teng Shenghan , Hu Wenhao 
Published: January 2016

AbstractThe presented cycloaddition is an auto‐tandem catalytic process which proceeds via an intermolecularly formed oxonium ylide which is trapped by the activated alkyne.
ChemInform Abstract: Visible‐Light‐Mediated Decarboxylative Benzoyloxylation of β‐Hydroxy Amino Acids and Its Application to Synthesis of Functional 1,2‐Amino Alcohol Derivatives.
Authors: Inuki Shinsuke , Sato Keisuke , Fujimoto Yukari 
Published: January 2016

AbstractA novel method is presented for decarboxylative benzoyloxylation of β‐hydroxy amino acid derivatives such as (I) and (XIV).
ChemInform Abstract: Silver(I) Oxide Nanoparticles as a Catalyst in the Azide—Alkyne Cycloaddition.
Authors: Ferretti Anna M. , Ponti Alessandro , Molteni Giorgio 
Published: January 2016

Abstract4‐Substituted 1,2,3‐triazoles are usually the main cycloadducts, but the presence of electron‐withdrawing groups on the azide moiety results in a loss of regioselectivity.
ChemInform Abstract: O‐Transfer‐Facilitated Cyclizations of Propargylamides with TMSN3: Selective Synthesis of Tetrazoles and Dihydroimidazoles.
Authors: Hu Yancheng , Yi Ruxia , Yu Xinzhang , Xin Xiaoyi , Wang Chunxiang , Wan Boshun 
Published: January 2016

AbstractIn addition to the selective preparation of functionalized tetrazoles and diiodomethylated dihydroimidazoles, diiodomethylated dihydrooxazoles are prepared.
ChemInform Abstract: Oxidant Controlled Regioselective Mono‐ and Di‐Functionalization Reactions of Coumarins.
Authors: Banerjee Arghya , Santra Sourav Kumar , Khatun Nilufa , Ali Wajid , Patel Bhisma K. 
Published: January 2016

AbstractThe site‐selective Fe(III)‐catalyzed C‐3 cycloalkylation or benzylation of 3‐substituted coumarins in the presence of di‐tert‐butylperoxide is described, and by switching to tert‐butylperoxide under metal‐free conditions C‐4 cycloalkylation with concomitant C‐3 peroxidation is observed.
ChemInform Abstract: Sonogashira Reaction of the Indolizine Ring.
Authors: Shadrin Ivan A. , Rzhevskii Sergey A. , Rybakov Victor B. , Babaev Eugene V. 
Published: January 2016

Abstract2‐Tert‐butyl‐5‐iodoindolizine is successfully coupled with aryl and alkylacetylenes as well as trimethylsilylacetylene.
ChemInform Abstract: An Unexpected Three‐Component Reaction of 2‐Alkylenecyclobutanone and N′‐(2‐Alkynylbenzylidene)hydrazide with Water.
Authors: Pan Xiaolin , Wang He , Xia Hong‐Guang , Wu Jie 
Published: January 2016

AbstractThe unexpected transformation involves a 6‐endo cyclization, [3+2]cycloaddition, and rearrangement leading to propanoic acid derivatives in good yields.
ChemInform Abstract: Copper‐Catalyzed Cross‐Coupling Affected by the Smiles Rearrangement: A New Chapter on Diversifying the Synthesis of Chiral Fluorinated 1,4‐Benzoxazine Derivatives.
Authors: Alapour Saba , Ramjugernath Deresh , Koorbanally Neil A. 
Published: January 2016

AbstractThe title benzoxazine derivatives containing F atoms as well as other halogens in different positions of the aromatic ring are obtained from their open chain precursors by copper catalyzed Smiles rearrangement ring closure.
ChemInform Abstract: B‐seco‐29‐nor‐Limonoids from the Stem Barks of Toona ciliate var. yunnanensis.
Authors: Yang Mei‐Si , Hu Sheng‐Mou , Kong Ling‐Yi , Luo Jun 
Published: January 2016

AbstractEight new compounds, including four rare B‐seco‐29‐nor‐limonoids, toonaciliatones A—D (I—IV), and four normal B‐seco‐limonoids, toonaciliatones E—H (V—VIII), together with six known compounds are isolated and their structures are elucidated.
ChemInform Abstract: Bisacremines E—G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105.
Authors: Wu Ping , Xue Jinghua , Yao Lei , Xu Liangxiong , Li Hanxiang , Wei Xiaoyi 
Published: January 2016

AbstractThe isolation and structure elucidation of three novel acremines is reported.
ChemInform Abstract: Structures and Biological Activities of Novel Biselyngbyaside Analogues Isolated from the Marine Cyanobacterium Lyngbya sp.
Authors: Watanabe Ayane , Ohno Osamu , Morita Maho , Inuzuka Toshiyasu , Suenaga Kiyotake 
Published: January 2016

AbstractThe new biselyngbyaside analogs, biselyngbyolide C (I) and biselyngbyasides E (II) and F (III), are found to inhibit the growth of HeLa and HL 60 cells.
ChemInform Abstract: Cytotoxic Polyprenylated Acylphloroglucinol Derivatives from Hypericum henryi.
Authors: Zhang Jing‐Jing , Yang Xing‐Wei , Ma Jun‐Zeng , Ye Ye , Shen Xiao‐Ling , Xu Gang 
Published: January 2016

AbstractBesides the previously unknown derivatives (I)—(IV), 12 known analogs were found as well.
ChemInform Abstract: Total Synthesis of Mycalolides A and B Through Olefin Metathesis.
Authors: Kita Masaki , Oka Hirotaka , Usui Akihiro , Ishitsuka Tomoya , Mogi Yuzo , Watanabe Hidekazu , Tsunoda Masaki , Kigoshi Hideo 
Published: January 2016

AbstractThe key steps of the asymmetric total synthesis of the trisoxazole marine macrolides, mycalolides A and B, are the convergent construction of highly functionalized C‐1—C‐19 trisoxazole and C‐20—C‐35 side chain segments using the olefin metathesis and esterification as well as the Julia—Kocienski olefination and enamide formation.
Material identification of three French medieval illuminations of the XVIth century by hyperspectral imaging (Treasury of Bordeaux Cathedral, France)
Authors: Aurélie Mounier , Charlotte Denoël , Floréal Daniel 
Published: January 2016

AbstractThe Marcadé Collection (treasury of Bordeaux Cathedral) includes 42 illuminations dating from the XIIIth to the XVIth century. Among them are three French medieval illuminations, dated about 1520–1530, never studied before. Beyond their iconographic, stylistic, and conservation study, the analysis of their materials is discussed here. Hyperspectral imaging technique is applied to characterize the pigments. The palette is composed of inorganic pigments such as azurite, red lead, cinnabar, yellow ochre, lead tin yellow, lead white, malachite, salt green and salts of copper, and also of organic pigments such as brazilwood lake, buckthorn, bucktooth and indigo. A shell gold technique is employed for the gildings. © 2016 Wiley Periodicals, Inc. Col Res Appl, 41, 302–307, 2016
Distinct roles of hand2 in developing and adult autonomic neurons
Authors: Stanzel Sabine , Stubbusch Jutta , Pataskar Abhijeet , Howard Marthe J. , Deller Thomas , Ernsberger Uwe , Tiwari Vijay K. , Rohrer Hermann , Tsarovina Konstantina 
Published: January 2016

ABSTRACTThe bHLH transcription factor Hand2 is essential for the acquisition and maintenance of noradrenergic properties of embryonic sympathetic neurons and controls neuroblast proliferation. Hand2 is also expressed in embryonic and postnatal parasympathetic ganglia and remains expressed in sympathetic neurons up to the adult stage. Here, we address its function in developing parasympathetic and adult sympathetic neurons. We conditionally deleted Hand2 in the parasympathetic sphenopalatine ganglion by crossing a line of floxed Hand2 mice with DbhiCre transgenic mice, taking advantage of the transient Dbh expression in parasympathetic ganglia. Hand2 elimination does not affect Dbh expression and sphenopalatine ganglion size at E12.5 and E16.5, in contrast to sympathetic ganglia. These findings demonstrate different functions for Hand2 in the parasympathetic and sympathetic lineage. Our previous Hand2 knockdown in postmitotic, differentiated chick sympathetic neurons resulted in decreased expression of noradrenergic marker genes but it was unclear whether Hand2 is required for maintaining noradrenergic neuron identity in adult animals. We now show that Hand2 elimination in adult Dbh‐expressing sympathetic neurons does not decrease the expression of Th and Dbh, in contrast to the situation during development. However, gene expression profiling of adult sympathetic neurons identified 75 Hand2‐dependent target genes. Interestingly, a notable proportion of down‐regulated genes (15%) encode for proteins with synaptic and neurotransmission functions. These results demonstrate a change in Hand2 target genes during maturation of sympathetic neurons. Whereas Hand2 controls genes regulating noradrenergic differentiation during development, Hand2 seems to be involved in the regulation of genes controlling neurotransmission in adult sympathetic neurons. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1111–1124, 2016
Enhanced susceptibility to seizures modulated by high interleukin‐1β levels during early life malnutrition
Authors: Simão Fabrício , Habekost Oliveira Victória , Nunes Magda Lahourgue 
Published: January 2016

ABSTRACTEarly malnutrition in life has permanent consequences on brain development and has been suggested to influence seizure susceptibility. Despite malnutrition is not a direct cause of seizures, we hypothesize that malnutrition may modulate inflammatory response and result in cerebral vulnerability to seizures. In this study, we provide evidence that malnutrition may increase susceptibility to seizures in the postnatal period by interleukin‐1β (IL‐1β) in the hippocampus. Malnourished rats were maintained on a nutritional deprivation regimen from postnatal day 1 (P1) to P10. From P7 to P10, the threshold to seizures induced by flurothyl was used as an index of seizure susceptibility. ELISA and western blot was performed to evaluate levels of IL‐1β, IL‐1R1, PSD‐95 and synapsin. The role of inflammation in the changes of seizure threshold was studied with inhibitors of IL‐1β and IL‐1R1. A significant decrease in body weight and seizure threshold was observed in postnatal malnourished rats. Early malnutrition modulates inflammation by high levels of IL‐1β in hippocampus and in serum. Furthermore, our malnutrition paradigm induced an increase in corticosterone levels. Injection of IL‐1β and IL‐1R1 inhibitors before seizure induction augments seizure threshold in malnourished rats similar to nourished group. Malnutrition did not change PSD‐95 and synapsin expression in the hippocampus. We suggest that malnutrition‐induced inflammation might contribute to seizure susceptibility in the postnatal period. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1150–1159, 2016
Are we overestimating the niche? Removing marginal localities helps ecological niche models detect environmental barriers
Authors: Soley‐Guardia Mariano , Gutiérrez Eliécer E. , Thomas Darla M. , Ochoa‐G José , Aguilera Marisol , Anderson Robert P. 
Published: January 2016

AbstractCorrelative ecological niche models (ENMs) estimate species niches using occurrence records and environmental data. These tools are valuable to the field of biogeography, where they are commonly used to infer potential connectivity among populations. However, a recent study showed that when locally relevant environmental data are not available, records from patches of suitable habitat protruding into otherwise unsuitable regions (e.g., gallery forests within dry areas) can lead to overestimations of species niches and their potential distributions. Here, we test whether this issue obfuscates detection of an obvious environmental barrier existing in northern Venezuela – that of the hot and xeric lowlands separating the Península de Paraguaná from mainland South America. These conditions most likely promote isolation between mainland and peninsular populations of three rodent lineages occurring in mesic habitat in this region. For each lineage, we calibrated optimally parameterized ENMs using mainland records only, and leveraged existing habitat descriptions to assess whether those assigned low suitability values corresponded to instances where the species was collected within locally mesic conditions amidst otherwise hot dry areas. When this was the case, we built an additional model excluding these records. We projected both models onto the peninsula and assessed whether they differed in their ability to detect the environmental barrier. For the two lineages in which we detected such problematic records, only the models built excluding them detected the barrier, while providing additional insights regarding peninsular populations. Overall, the study reveals how a simple procedure like the one applied here can deal with records problematic for ENMs, leading to better predictions regarding the potential effects of the environment on lineage divergence.
Loss of genetic integrity and biological invasions result from stocking and introductions of Barbus barbus: insights from rivers in England
Authors: Antognazza Caterina Maria , Andreou Demetra , Zaccara Serena , Britton Robert J. 
Published: January 2016

AbstractAnthropogenic activities, including the intentional releases of fish for enhancing populations (stocking), are recognized as adversely impacting the adaptive potential of wild populations. Here, the genetic characteristics of European barbel Barbus barbus were investigated using 18 populations in England, where it is indigenous to eastern‐flowing rivers and where stocking has been used to enhance these populations. Invasive populations are also present in western‐flowing rivers following introductions of translocated fish. Two genetic clusters were evident in the indigenous range, centered on catchments in northeast and southeast England. However, stocking activities, including the release of hatchery‐reared fish, have significantly reduced the genetic differentiation across the majority of this range. In addition, in smaller indigenous rivers, populations appeared to mainly comprise fish of hatchery origin. In the nonindigenous range, genetic data largely aligned to historical stocking records, corroborating information that one particular river (Kennet) in southeast England was the original source of most invasive B. barbus in England. It is recommended that these genetic outputs inform management measures to either restore or maintain the original genetic diversity of the indigenous rivers, as this should help ensure populations can maintain their ability to adapt to changing environmental conditions. Where stocking is considered necessary, it is recommended that only broodstock from within the catchment is used.
Body mass index in acute heart failure: association with clinical profile, therapeutic management and in‐hospital outcome
Authors: Parissis John , Farmakis Dimitrios , Kadoglou Nikolaos , Ikonomidis Ignatios , Fountoulaki Ekaterini , Hatziagelaki Erifili , Deftereos Spyridon , Follath Ferenc , Mebazaa Alexandre , Lekakis John , Filippatos Gerasimos 
Published: January 2016

AbstractBackgroundIncreased body mass index (BMI) is a risk factor for heart failure, but evidence regarding BMI in acute heart failure (AHF) remains inconclusive. We sought to compare the clinical profile, treatment and in‐hospital outcome across BMI categories in a large international AHF cohort.MethodsThe Acute Heart Failure Global Survey of Standard Treatment (ALARM‐HF) is a retrospective survey on 4953 patients admitted for AHF from nine countries in Europe, Latin America, and Australia. Patients with unavailable BMI data or BMI <18.5 kg/m2 were excluded. Clinical data and in‐hospital mortality were compared among the following BMI categories: 18.5–24.9 kg/m2 (normal weight), 25–29.9 kg/m2 (overweight) and ≥30 kg/m2 (obese).ResultsOverweight/obese patients represented 75.7% of patients and had worse New York Heart Association class (P < 0.001) and higher admission systolic blood pressure (P < 0.001). The prevalence of comorbidities increased in parallel with BMI and included arterial hypertension, diabetes mellitus, dyslipidaemia (all P < 0.001), chronic obstructive pulmonary disease (P = 0.041) and chronic kidney disease (P = 0.056). Use of guideline‐recommended medications also increased in parallel with BMI (angiotensin converting enzyme inhibitors/angiotensin II receptor blockers, P < 0.001; β‐blockers P < 0.001; mineralocorticoid receptors antagonist, P = 0.002). In‐hospital mortality had a U‐shaped relationship with BMI, with overweight patients having significantly lower rate (log‐rank P = 0.027); this relationship vanished after adjustment for confounders.ConclusionsOverweight/obese patients represented the vast majority of AHF cases, had a higher prevalence of non‐cardiovascular comorbidities and were more likely to receive guideline‐recommended medications. The U‐shaped relationship between in‐hospital mortality and BMI may be explained by differences in clinical profile and treatment and not by an effect of body composition per se.
Principles of geomorphic disturbance and recovery in response to storms
Authors: Phillips Jonathan D. , Van Dyke Chris 
Published: January 2016

AbstractThe most important geomorphic responses to storms are qualitative changes in system state. Minor storms produce no state change or very rapid recovery to pre‐storm state, and extinction events wipe out the system. In other cases disturbance results in a state change, which may be transitional (change to a previously existing state), state space expansion (change to a new state), and clock‐resetting events that return the system to its initial state. Recovery pathways are much more varied than the monotonic progressions represented in classic vegetation succession and linear channel evolution models. Those linear sequential pathways are only one of several archetypal recovery pathways, which also include binary, convergent, divergent, and more complex networks. Filter‐dominated systems are more likely to follow linear sequential or convergent patterns, whereas amplifier‐dominance is characteristic of divergent and more complex mesh or fully‐connected patterns. Amplifier domination is also more likely to lead to evolutionary or state space expansion responses. Amplification and filtering in geomorphic response and recovery can be assessed using the 'Four R's' framework of response, resistance, relaxation, and recursion. High resistance and resilience, rapid relaxation times, and stable recursive feedback networks reduce or offset effects of disturbances, thus filtering their impacts. Conversely, low resistance and resilience, slow relaxation, and dynamically unstable feedbacks can exaggerate disturbances, creating disproportionately large and long‐lived impacts, thereby amplifying disturbances.Unless new filter mechanisms evolve (either autogenically or anthropically), or the number of extinction or clock‐resetting events increases, intensified storminess will result in more geomorphic variability. These ideas are applied to a case study of a flood on the Clark Fork River, Montana, USA. Copyright © 2016 John Wiley & Sons, Ltd.
Preliminary Evaluation of a Social Skills Training and Facilitated Play Early Intervention Programme for Extremely Shy Young Children in China
Authors: Li Yan , Coplan Robert J. , Wang Yuemin , Yin Jingtong , Zhu Jingjing , Gao Zhuqing , Li Linhui 
Published: January 2016

AbstractThe goal of this study was to provide a preliminary evaluation of a social skills and facilitated play early intervention programme to promote social interaction, prosocial behaviours and socio‐communicative skills among young extremely shy children in China. Participants were a sample of n = 16 extremely shy young children attending kindergarten in Shanghai, China. Children were randomly assigned to either the Social Skills Facilitated Play or comparison condition. Baseline, post‐intervention and 2‐month follow‐up measures included observations of children's social behaviours in quartets of novel peers. Result indicated that as compared with shy controls, shy children who participated in the Social Skills Training Facilitated Play programme were observed to demonstrate significantly greater post‐intervention frequencies of peer interactions (e.g. group play and peer conversation) and prosocial behaviours (e.g. cooperation, sharing and making/accepting social initiations) during unstructured free play with novel peers, as well as better social‐communicative competence during a speech task. Almost all of these improvements were maintained 2 months post‐intervention. Results are discussed in terms of the importance of developing and refining early intervention programmes for extremely shy young children in China. Copyright © 2016 John Wiley & Sons, Ltd.