bluuebunny/crossref_metadata_2025_split huggingface dataset:
T cells for viral infections after allogeneic hematopoietic stem cell transplant
Authors: Bollard Catherine M. , Heslop Helen E. 
Published: May 2016

Abstract
Despite recent advances in the field of allogeneic hematopoietic stem cell transplantation (HSCT), viral infections are still a major complication during the period of immune suppression that follows the procedure. Adoptive transfer of donor-derived virus-specific cytotoxic T cells (VSTs) is a strategy to rapidly restore virus-specific immunity to prevent or treat viral diseases after HSCT. Early proof of principle studies demonstrated that the administration of donor-derived T cells specific for cytomegalovirus or Epstein-Barr virus (EBV) could effectively restore virus-specific immunity and control viral infections. Subsequent studies using different expansion or direct selection techniques have shown that donor-derived VSTs confer protection in vivo after adoptive transfer in 70% to 90% of recipients. Because a major cause of failure is lack of immunity to the infecting virus in a naïve donor, more recent studies have infused closely matched third-party VSTs and reported response rates of 60% to 70%. Current efforts have focused on broadening the applicability of this approach by: (1) extending the number of viral antigens being targeted, (2) simplifying manufacture, (3) exploring strategies for recipients of virus-naïve donor grafts, and (4) developing and optimizing “off the shelf” approaches.
Metastatic malignant struma ovarii with coexistence of Hashimoto’s thyroiditis
Authors: Russo Marco , Marturano Ilenia , Masucci Romilda , Caruso Melania , Fornito Maria Concetta , Tumino Dario , Tavarelli Martina , Squatrito Sebastiano , Pellegriti Gabriella 
Published: May 2016

Summary
Struma ovarii is a rare ovarian teratoma characterized by the presence of thyroid tissue as the major component. Malignant transformation of the thyroidal component (malignant struma ovarii) has been reported in approximately 5% of struma ovarii. The management and follow-up of this unusual disease remain controversial. We report the case of a woman with a history of autoimmune thyroiditis and a previous resection of a benign struma ovarii that underwent hystero-annexiectomy for malignant struma ovarii with multiple papillary thyroid cancer foci and peritoneal involvement. Total thyroidectomy and subsequent radioiodine treatment lead to complete disease remission after 104 months of follow-up. The diagnosis and natural progression of malignant struma ovarii are difficult to discern, and relapses can occur several years after diagnosis. A multidisciplinary approach is mandatory; after surgical excision of malignant struma, thyroidectomy in combination with 131I therapy should be considered after risk stratification in accordance with a standard approach in differentiated thyroid cancer patients.

Learning points

Malignant struma ovarii is a rare disease; diagnosis is difficult and management is not well defined.
Predominant sites of metastasis are adjacent pelvic structures.
Thyroidectomy and 131I therapy should be considered after risk stratification in accordance with standard approaches in DTC patients.
Retrospective Cohort Study of Phototherapy and Childhood Cancer in Northern California
Authors: Newman Thomas B. , Wickremasinghe Andrea C. , Walsh Eileen M. , Grimes Barbara A. , McCulloch Charles E. , Kuzniewicz Michael W. 
Published: May 2016

OBJECTIVE:To investigate the association between neonatal phototherapy use and childhood cancer.METHODS:This retrospective cohort study included 499 621 children born at ≥35 weeks’ gestation from 1995 to 2011 in Kaiser Permanente Northern California hospitals, who survived to hospital discharge and were followed ≥60 days. We obtained data on home and inpatient phototherapy, covariates, and cancer incidence from electronic records. We used propensity-adjusted Cox and Poisson models to control for confounding and unequal follow-up times.RESULTS:There were 60 children with a diagnosis of cancer among 39 403 exposed to phototherapy (25 per 100 000 person-years), compared with 651 of 460 218 unexposed children (18 per 100 000 person-years; incidence rate ratio [IRR] 1.4; P = .01). Phototherapy was associated with increased rates of any leukemia (IRR 2.1; P = .0007), nonlymphocytic leukemia (IRR 4.0; P = .0004), and liver cancer (IRR 5.2; P = .04). With adjustment for a propensity score that incorporated bilirubin levels, chromosomal disorders, congenital anomalies, and other covariates, associations were no longer statistically significant: Adjusted hazard ratios (95% confidence intervals) were 1.0 (0.7–1.6) for any cancer, 1.6 (0.8–3.5) for any leukemia, 1.9 (0.6–6.9) for nonlymphocytic leukemia, and 1.4 (0.2–12) for liver cancer. Upper limits of 95% confidence intervals for adjusted 10-year excess risk were generally &lt;0.1% but reached 4.4% for children with Down syndrome.CONCLUSIONS:Although phototherapy use was associated with increased cancer rates (particularly nonlymphocytic leukemia), control for confounding variables eliminated or attenuated the associations. Nonetheless, the possibility of even partial causality suggests that avoiding unnecessary phototherapy may be prudent.
Terra nullius, Inuit Habitation and Norse Occupation – With Special Emphasis on the 1933 East Greenland Case
Authors: Ørebech Peter Thomas 
Published: May 2016

Sovereignty acquired by occupation entails “recognize[d] title based on discovery,” “a reasonable period [of] … effective occupation of the region claimed to be discovered” and “the continuous and peaceful display of State authority.” Only terra nullius is subject to occupation. A territory inhabited by indigenous groups that sustain social and political organization may impede an occupying power because the terra nullius requirement fails. While sovereignty over thinly populated areas are often lax, case law requires less public involvement in these sparsely inhabited areas. This study reveals that the Dano-Norwegian Kings regarded the Inuit as “our subjects.” The Kings’ pretention of absolutum dominium and jurisdiction involved both the Norse and Inuit ethnic groups and “bygð ok ubygð” (settled and unsettled) land. The exodus of the Norse peoples in 1450 AD for 200 years did not undermine the acquired sovereignty of the Dano-Norwegian Crown, which as a result, spoiled the 1931 Norwegian pretentions to legally occupy East-Greenland. Denmark’s triumph in the 1933-East Greenland case resulted from a “zero-sum principle.” More than a 100 years earlier, the Danish Kingdom lost a succession of countries and dependencies. The 1814 Kiel Treaty transferred mainland Norway to Sweden, but explicitly states that none of the ancient Norwegian dependencies, Greenland, Iceland and Faroe Islands would follow suit. Thus, these territories remained part of the Kingdom of Denmark.(Published: May 2016)Citation: P. T. Ørebech. “Terra nullius, Inuit Habitation and Norse Occupation – With Special Emphasis on the 1933 East Greenland Case.” Arctic Review on Law and Politics, Vol. 7, No. 1, 2016, pp. 20–41. http://dx.doi.org/10.17585/arctic.v7.262
The presence of Chlamydia phage PhiCPG1 capsid protein VP1 genes and antibodies in patients infected with Chlamydia trachomatis
Authors: Ma Jingyue , Liu Yuan , Liu Yuanjun , Li Lingjie , Hou Shuping , Gao Xibo , Qi Manli , Liu Quanzhong 
Published: May 2016

Chlamydia phage PhiCPG1 has been found in Chlamydia caviae in a guinea pig model for inclusion conjunctivitis, raising the possibility that Chlamydia phage is also present in patients infected with C. trachomatis (Ct). In the present study, we assayed for presence of Chlamydia phage capsid protein VP1 genes and antibodies in 84 non-Ct controls and 206 Ct patients using an enzyme-linked immunoassay (ELISA), followed by verification with Western blot. None of the subjects were exposed to an antibiotic treatment or had a C. pneumoniae infection. The VP1 antibody test was positive in both, the ELISA and Western blot assay, in 4 Ct patients. PCR amplification experiments revealed presence of the VP1 gene in 5 Ct patients. The results suggest that Chlamydia phage capsid protein VP1 may exist in some Ct patients.
Bone Marrow CD11c+ Cell–Derived Amphiregulin Promotes Pulmonary Fibrosis
Authors: Ding Lin , Liu Tianju , Wu Zhe , Hu Biao , Nakashima Taku , Ullenbruch Matthew , Gonzalez De Los Santos Francina , Phan Sem H. 
Published: May 2016

Abstract
Amphiregulin (AREG), an epidermal growth factor receptor ligand, is implicated in tissue repair and fibrosis, but its cellular source and role in regeneration versus fibrosis remain unclear. In this study, we hypothesize that AREG induced in bone marrow–derived CD11c+ cells is essential for pulmonary fibrosis. Thus, the objectives were to evaluate the importance and role of AREG in pulmonary fibrosis, identify the cellular source of AREG induction, and analyze its regulation of fibroblast function and activation. The results showed that lung AREG expression was significantly induced in bleomycin-induced pulmonary fibrosis. AREG deficiency in knockout mice significantly diminished pulmonary fibrosis. Analysis of AREG expression in major lung cell types revealed induction in fibrotic lungs predominantly occurred in CD11c+ cells. Moreover, depletion of bone marrow–derived CD11c+ cells suppressed both induction of lung AREG expression and pulmonary fibrosis. Conversely, adoptive transfer of bone marrow–derived CD11c+ cells from bleomycin-treated donor mice exacerbated pulmonary fibrosis, but not if the donor cells were made AREG deficient prior to transfer. CD11c+ cell-conditioned media or coculture stimulated fibroblast proliferation, activation, and myofibroblast differentiation in an AREG-dependent manner. Furthermore, recombinant AREG induced telomerase reverse transcriptase, which appeared to be essential for the proliferative effect. Finally, AREG significantly enhanced fibroblast motility, which was associated with increased expression of α6 integrin. These findings suggested that induced AREG specifically in recruited bone marrow–derived CD11c+ cells promoted bleomycin-induced pulmonary fibrosis by activation of fibroblast telomerase reverse transcriptase–dependent proliferation, motility, and indirectly, myofibroblast differentiation.
Products of Admissible Monomials in the Polynomial Algebra as a Module over the Steenrod Algebra
Authors: Mothebe Mbakiso Fix 
Published: May 2016

Let ${\P}(n) ={\F}[x_1,\ldots,x_n]$ be the polynomial algebra in $n$ variables $x_i$, of degree one, over the field $\F$ of two elements. The mod-2 Steenrod algebra $\A$ acts on ${\P }(n)$ according to well known rules. A major problem in algebraic topology is that of determining $\A^+{\P}(n)$, the image of the action of the positively graded part of $\A$. We are interested in the related problem of determining a basis for the quotient vector space ${\Q}(n) = {\P}(n)/\A^{+}\P(n)$. Both ${\P }(n) =\bigoplus_{d \geq 0} {\P}^{d}(n)$ and ${\Q}(n)$ are graded, where ${\P}^{d}(n)$ denotes the set of homogeneous polynomials of degree $d$. ${\Q}(n)$ has been explicitly calculated for $n=1,2,3,4$ but problems remain for $n \geq 5.$ In this note we show that if $u = x_{1}^{m_1} \cdots x_{k}^{m_{k}} \in {\P}^{d}(k)$ and $v = x_{1}^{e_1} \cdots x_{r}^{e_{r}} \in {\P}^{d'}(r)$ are an admissible monomials, (that is, $u$ and $v$ meet a criterion to be in a certain basis for ${\Q}(k)$ and ${\Q}(r)$ respectively), then for each permutation $\sigma \in S_{k+r}$ for which $\sigma(i)&lt;\sigma(j),$ $i&lt;j\leq k$ and $\sigma(s)&lt;\sigma(t),$ $k&lt;s&lt;t\leq k+r,$ the monomial $x_{\sigma(1)}^{m_1} \cdots x_{\sigma(k)}^{m_{k}} x_{\sigma(k+1)}^{e_1} \cdots x_{\sigma(k+r)}^{e_r} \in {\P}^{d+d'}(k+r)$ is admissible. As an application we consider a few cases when $n=5.$
Sustentabilidade e educação superior: análise das ações de sustentabilidade de duas instituições de ensino superior de Santa Catarina
Authors: Pontes Andrea Simone Machiavelli , Carneiro Caroline , Petry David Rodrigo , Pilatti Citania Aparecida , Sehnem Simone 
Published: May 2016

This qualitative and descriptive study, aims to understand the concepts of sustainability and identify how they are included in the action planning of Higher Education Institutions (HEI) of Santa Catarina. Therefore, a brief literature review on the topic of sustainability was held and on the relationship of sustainability with education and later with the HEI. The problem of this study consists in identify how the surveyed HEIs are inserting sustainability in a practical way, in the institution´s activities. The disclosed results showed that HEI adopt attitudes that meet the global context, both in its institutional actions, including the practice of the courses offered to its target audience, and in its image in the community. Thus, through the printed documents analysis and information available in the corporate website of the HEIs studied - National Service of Commercial Education (SENAC/SC) and Educational Society of Santa Catarina (SOCIESC), it was possible to identify that both organizations adopt actions and practices for the inclusion of sustainability in its institutional activities, which responds readily to the general purpose of this study.
Tunnel Vision
Authors: Garrison Thomas G. , Richmond Dustin , Naughton Perry , Lo Eric , Trinh Sabrina , Barnes Zachary , Lin Albert , Schurgers Curt , Kastner Ryan , Newman Sarah E. 
Published: May 2016

AbstractArchaeological tunneling is a standard excavation strategy in Mesoamerica. The ancient Maya built new structures atop older ones that were no longer deemed usable, whether for logistical or ideological reasons. This means that as archaeologists excavate horizontal tunnels into ancient Maya structures, they are essentially moving back in time. As earlier constructions are encountered, these tunnels may deviate in many directions in order to document architectural remains. The resultant excavations often become intricate labyrinths, extending dozens of meters. Traditional forms of archaeological documentation, such as photographs, plan views, and profile drawings, are limited in their ability to convey the complexity of tunnel excavations. Terrestrial Lidar (light detection and ranging) instruments are able to generate precise 3D models of tunnel excavations. This article presents the results of a model created with a Faro™ Focus 3D 120 Scanner of tunneling excavations at the site of El Zotz, Guatemala. The lidar data document the excavations inside a large mortuary pyramid, including intricately decorated architecture from an Early Classic (A.D. 300–600) platform buried within the present form of the structure. Increased collaboration between archaeologists and scholars with technical expertise maximizes the effectiveness of 3D models, as does presenting digital results in tandem with traditional forms of documentation.
Role of Doppler Sonography in Early Detection of Splenic Steal Syndrome
Authors: Li Chaolun , Quintini Cristiano , Hashimoto Koji , Fung John , Obuchowski Nancy A. , Sands Mark J. , Wang Weiping 
Published: May 2016

ObjectivesTo retrospectively investigate the role of Doppler sonography in the early detection of splenic steal syndrome.MethodsFifty cases of splenic steal syndrome after orthotopic liver transplantation were identified. A control group was matched to the splenic steal syndrome group. Information was collected about the clinical presentation, liver enzyme levels, Doppler sonographic results, and follow‐up after patients underwent splenic artery embolization.ResultsA persistent hepatic arterial diastolic reversal waveform was observed in 25 patients with splenic steal syndrome versus 0 control patients. The mean hepatic arterial resistive index (RI) values ± SD were 0.95 ± 0.09 in patients with splenic steal syndrome and 0.80 ± 0.10 in control patients (P < .0001). One week after orthotopic liver transplantation, the area under the receiver operating characteristic curve for the RI was 0.884 (95% confidence interval, 0.793–0.975; P = .001) for splenic steal syndrome diagnosis. After splenic artery embolization, there was normalization of the reversal waveform, with an average RI of 0.77 ± 0.11 (P < .0001).ConclusionsDynamic changes in the hepatic arterial waveform and RI are keys to detecting splenic steal syndrome with Doppler sonography.
Increased precipitation and weathering across the Paleocene‐Eocene Thermal Maximum in central China
Authors: Chen Zuoling , Ding Zhongli , Yang Shiling , Zhang Chunxia , Wang Xu 
Published: May 2016

AbstractGlobal warming during the Paleocene‐Eocene Thermal Maximum (PETM) ∼55.5 million years ago (Ma) was associated with a massive release of carbon to the ocean‐atmosphere system, as evidenced by a prominent negative carbon isotope excursion (CIE) and widespread dissolution of marine carbonates. The paleohydrologic response to the PETM warming has been studied worldwide; however, relevant records of environmental perturbation in Asia are lacking so far. Here we extend the record of this event in central China, a subtropical paleosetting, through geochemical and mineralogical analyses of lacustrine sediments. Geochemical indicators of authigenic carbonates—including molar Mg/Ca and Sr/Ca ratios—suggest an overall increased precipitation across the PETM, compatible with the disappearance of authigenic dolomite and the appearance of kaolinite in the strata. The relatively humid conditions persisted long after the carbon‐cycle perturbation had stopped, implying that the transient hyper‐greenhouse warming might have forced the regional climate system into a new climate state that was not easily reversed. Additionally, a gradual increase in chemical index of alteration (CIA) and the appearance of kaolinite are associated with the PETM, indicating an intensified silicate weathering and pedogenesis in the watershed in response to warmer and more humid climate. Our results corroborate the theory that an accelerated continental chemical weathering served as a negative feedback to sequester carbon and lower the atmospheric greenhouse‐gas levels during the PETM.
ChemInform Abstract: Hydroboration of Hetero(Si, Ge, Sn)‐Substituted Acetylene Ethers. Synthesis of cis‐β‐Hetero(Si, Ge, Sn)‐Substituted Vinyl Ethers.
Authors: PONOMAREV S. V. , ERIKOVA M. V. , NIKOLAEVA S. N. , ZEL' R. , KOSTYUK A. S. 
Published: May 2016

AbstractHydroboration of the acetylene ethers (I) with the boranes (II) and subsequent work‐up with higher alkanols yield stereo‐ and regioselectitively the cis‐vinyl ethers (IV).
ChemInform Abstract: Eu4OCl6 and Eu4OBr6: Crystal Growth and Structure.
Authors: SCHLEID T. , MEYER G. 
Published: May 2016

AbstractSingle crystals of the title compound have been prepared by reduction of a EuX3 (X: Cl, Br)/Eu2O3 mixture (6:1) with Li metal (Ta‐ampoules, 850 °C, and 750 °C, resp., 1 week).
ChemInform Abstract: Interlamellar Liebig Titration Based on Photoluminescence. Reaction of Silver Uranyl Phosphate with Hydrogen Cyanide Gas.
Authors: DIECKMANN G. H. , ELLIS A. B. 
Published: May 2016

AbstractThe interlamellar equivalent of the Liebig titration is demonstrated: AgCN can be precipitated by the solid‐gas reaction of (I) with HCN.
ChemInform Abstract: Chemical Transport in the System Mn‐O in Consideration of the Oxygen Coexistence Pressure.
Authors: ROSSBERG A. , OPPERMANN H. , STARKE R. 
Published: May 2016

AbstractThe chemical transport of the coexistent phases Mn2O3‐Mn3O4 and Mn3O4‐MnO with Cl2, Br2, HCl, HBr, and HI has been studied and thermodynamically analyzed.
ChemInform Abstract: Effects of Counterions on Crack Growth in Vitreous Silica.
Authors: WHITE G. S. , FREIMAN S. W. , WIEDERHORN S. M. , COYLE T. D. 
Published: May 2016

AbstractCrack‐growth studies are performed in Cs, K, Na, Li, and Tl(I) hydroxide solutions as a function of pH (emphasis on pH ≥ 11).
ChemInform Abstract: (PPh3Me)2((MoCl4(NO))2(μ‐S2N2)); Synthesis, IR Spectrum, and Crystal Structure.
Authors: FRANKENAU A. , DEHNICKE K. , FENSKE D. 
Published: May 2016

AbstractThe title compound (III), prepared as shown in the scheme, crystallizes in the triclinic space group P1 with Z=1.
ChemInform Abstract: Convenient Synthesis of the Chevrel Phases MxMo6S8 (M: Cu, Pb, La, or Gd).
Authors: NANJUNDASWAMY K. S. , VASANTHACHARYA N. Y. , GOPALAKRISHNAN J. , RAO C. N. R. 
Published: May 2016

AbstractNearly stoichiometric Cu2Mo6S8 (I), PbMo6S8 (II), LaMo6S8 (III), and GdMo6S8 (IV) are obtained as single‐phase products by heating a precursor of general formula Mp(NH4)qMo3S9 in H2 at 1000 °C. The precursors are prepared by addition of a DMF solution of the corresponding metal chloride to a DMF solution of (NH4)2MoS4 (∼ 90 °C, 5‐6 h, N2).
ChemInform Abstract: Characterization of Ferrocene and (η6‐Benzene) Tricarbonylchromium Complexes by X‐Ray Photoelectron Spectroscopy.
Authors: ALLEN G. C. , BUTLER I. S. , KIRBY C. 
Published: May 2016

AbstractThe binding energies of the 2p electrons in the complexes (I)‐(IV) indicate that the actual oxidation states of the metals are close to zero.
ChemInform Abstract: Anion Coordination Chemistry. Part 2. Electrochemical, Thermodynamic, and Structural Studies on Supercomplex Formation Between Large Polyammonium Cycloalkanes and the Two Complex Anions Hexacyanoferrate(II) and Hexacyanocobaltate(III).
Authors: BENCINI A. , BIANCHI A. , GARCIA‐ESPANA E. , GIUSTI M. , MANGANI S. , MICHELONI M. , ORIOLI P. , PAOLETTI P. 
Published: May 2016

AbstractThe stability constants of 1:1 "supercomplexes" formed between the large, variously protonated macrocycles (I) and the anions (Fe(CN)6)4‐ and (Co(CN)6)3‐ are determined by potentiometric studies.
ChemInform Abstract: Substitution Reactions of Organocuprates with β‐(Phenylseleno)vinyl Sulfones Derived from the Selenosulfonation of Acetylenes. A Convenient and Stereospecific Preparation of Vinyl Sulfones and Olefins from Acetylenes.
Authors: BACK T. G. , COLLINS S. , KRISHNA M. V. , LAW K.‐W. 
Published: May 2016

AbstractThe 2‐selenenylvinyl sulfones (I), prepared from the corresponding acetylenes by free‐radical selenosulfonation, react with the organocuprates, generated in situ from the lithium compounds (II), to form the substitution products (III).
ChemInform Abstract: Cycloaddition Reactions of a Bisisobenzofuran Leading to Linear Polyacenequinones and a Quadruply Bridged Cyclophane.
Authors: CHIBA T. , KENNY P. W. , MILLER L. L. 
Published: May 2016

AbstractThe bisisobenzofuran (I) undergoes cycloaddition reactions with maleic anhydride (IIa) or the maleimides (IIb) and (IIc), yielding the bisadducts (III).
ChemInform Abstract: Oxidation of Organic Compounds by Silver(II). Reactions with Aliphatic Diols and α‐Hydroxy Acids.
Authors: MENTASTI E. , KIRSCHENBAUM L. J. 
Published: May 2016

AbstractThe rates of oxidation of the compounds (I) and (II) are investigated by the stopped‐flow technique and a mechanism via the formation of a Ag(I)‐diol complex is proposed.
ChemInform Abstract: Selective Monofluorination of β‐Diketones.
Authors: PURRINGTON S. T. , BUMGARDNER C. L. , LAZARIDIS N. V. , SINGH P. 
Published: May 2016

AbstractThe 1,3‐diketones (I) are selectively fluorinated to give the monofluoro diones (IV) by treatment of the corresponding silyl enol ethers (III) with diluted fluorine in nitrogen.
ChemInform Abstract: Novel Reactions of the Low Valent Cobalt Reagent Generated Using CoCl2 and NaBH4/C2H5OH in the Presence of Carbon Monoxide.
Authors: SATYANARAYANA N. , PERIASAMY M. 
Published: May 2016

AbstractReaction of the terminal olefin (I) with sodium boranate, CoCl2 (II), and carbon monoxide (III) proceeds via the complex (IV) which yields either the alkane (V) or the rearranged E‐alkene (VI) depending on the method of work‐up.
ChemInform Abstract: A Simple Synthesis of Tropones and Related Compounds.
Authors: BARBIER M. , BARTON D. H. R. , DEVYS M. , TOPGI R. S. 
Published: May 2016

AbstractThe cyclohexa‐2,4‐ and 2,5‐dienones bearing a dihalomethyl group at positions 2 or 4, cf.