bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Solar cycle correlation of coronal element abundances in Sun-as-a-star observations
Authors: Brooks David H. , Baker Deborah , van Driel-Gesztelyi Lidia , Warren Harry P. 
Published: July 2017

AbstractThe elemental composition in the coronae of low-activity solar-like stars appears to be related to fundamental stellar properties such as rotation, surface gravity, and spectral type. Here we use full-Sun observations from the Solar Dynamics Observatory, to show that when the Sun is observed as a star, the variation of coronal composition is highly correlated with a proxy for solar activity, the F10.7 cm radio flux, and therefore with the solar cycle phase. Similar cyclic variations should therefore be detectable spectroscopically in X-ray observations of solar analogs. The plasma composition in full-disk observations of the Sun is related to the evolution of coronal magnetic field activity. Our observations therefore introduce an uncertainty into the nature of any relationship between coronal composition and fixed stellar properties. The results highlight the importance of systematic full-cycle observations for understanding the elemental composition of solar-like stellar coronae.
Self-healing of damage inside metals triggered by electropulsing stimuli
Authors: Song Hui , Wang Zhong-jin , He Xiao-dong , Duan Jie 
Published: July 2017

AbstractThe microscopic defects that distributed randomly in metals are not only hard to detect, but also may inevitably cause catastrophic failure. Thus, autonomic probing and healing for damage inside metals continue to be a challenging. Here we show a novel approach for self-healing using electropulsing as a stimulus to trigger repairing of damaged metals. This is achieved via a process that through expelling absolutely currents, the microcrack causes them to be redistributed to form a concentrated and a diluted region around it, thereby inducing an extremely high temperature gradient and a large compressive stress, which drive material flow to close microcracks. Simultaneously, a large enough heat for bonding atoms was produced. That is, the microcrack as an empty cavity can be regarded as a special micro-device to shape a localized microscopic energy field, which in turn activates a healing process. The microstructure and mechanical property verified the extrinsic self-healing of a titanium alloy. The process is performed on a short timescale, is enable to detect automatically and act directly on the internal defects in metals, and to heal damage without any healing agent, long time heating as well as applied high pressure, offering unique advantages over conventional healing approaches.
Refractory period in network models of excitable nodes: self-sustaining stable dynamics, extended scaling region and oscillatory behavior
Authors: Moosavi S. Amin , Montakhab Afshin , Valizadeh Alireza 
Published: July 2017

AbstractNetworks of excitable nodes have recently attracted much attention particularly in regards to neuronal dynamics, where criticality has been argued to be a fundamental property. Refractory behavior, which limits the excitability of neurons is thought to be an important dynamical property. We therefore consider a simple model of excitable nodes which is known to exhibit a transition to instability at a critical point (λ = 1), and introduce refractory period into its dynamics. We use mean-field analytical calculations as well as numerical simulations to calculate the activity dependent branching ratio that is useful to characterize the behavior of critical systems. We also define avalanches and calculate probability distribution of their size and duration. We find that in the presence of refractory period the dynamics stabilizes while various parameter regimes become accessible. A sub-critical regime with λ < 1.0, a standard critical behavior with exponents close to critical branching process for λ = 1, a regime with 1 < λ < 2 that exhibits an interesting scaling behavior, and an oscillating regime with λ > 2.0. We have therefore shown that refractory behavior leads to a wide range of scaling as well as periodic behavior which are relevant to real neuronal dynamics.
Prediction of thermal boundary resistance by the machine learning method
Authors: Zhan Tianzhuo , Fang Lei , Xu Yibin 
Published: July 2017

AbstractThermal boundary resistance (TBR) is a key property for the thermal management of high power micro- and opto-electronic devices and for the development of high efficiency thermal barrier coatings and thermoelectric materials. Prediction of TBR is important for guiding the discovery of interfaces with very low or very high TBR. In this study, we report the prediction of TBR by the machine learning method. We trained machine learning models using the collected experimental TBR data as training data and materials properties that might affect TBR as descriptors. We found that the machine learning models have much better predictive accuracy than the commonly used acoustic mismatch model and diffuse mismatch model. Among the trained models, the Gaussian process regression and the support vector regression models have better predictive accuracy. Also, by comparing the prediction results using different descriptor sets, we found that the film thickness is an important descriptor in the prediction of TBR. These results indicate that machine learning is an accurate and cost-effective method for the prediction of TBR.
Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency
Authors: Chang Ming-Yang , Ma Tsu-Lin , Hung Cheng-Chieh , Tian Ya-Chung , Chen Yung-Chang , Yang Chih-Wei , Cheng Yi-Chuan 
Published: July 2017

AbstractAutosomal dominant polycystic kidney disease (ADPKD) is a common kidney disease caused by mutations in PKD1 or PKD2. Metformin reduces cyst growth in mouse models of PKD1. However, metformin has not been studied in animal models of PKD2, and the cellular mechanism underlying its effectiveness is not entirely clear. This study investigated the effects of metformin on cyst formation in a zebrafish model of polycystin-2 deficiency resulting from morpholino knockdown of pkd2. We added metformin (2.5 to 20 mM) to the embryo media between 4 and 48 hours post fertilisation and observed pronephric cyst formation by using the wt1b promoter-driven GFP signal in Tg(wt1b:GFP) pkd2 morphants. Metformin inhibited pronephric cyst formation by 42–61% compared with the untreated controls. Metformin also reduced the number of proliferating cells in the pronephric ducts, the degree of dorsal body curvature, and the infiltration of leukocytes surrounding the pronephros. Moreover, metformin treatment increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and enhanced autophagy in the pronephros. Our data suggest that metformin reduces cyst formation through activation of the AMPK pathway and modulation of defective cellular events such as proliferation and autophagy. These results also imply that metformin could have therapeutic potential for ADPKD treatment.
An alternative microRNA-mediated post-transcriptional regulation of GADD45A by p53 in human non-small-cell lung cancer cells
Authors: Li Jie , Dong Jie , Li Shaohua , Xia Wei , Su Xueting , Qin Xingliang , Chen Ying , Ding Hongmei , Li Hui , Huang Aixue , Bai Chenjun , Hu Tongnan , Wang Chenglong , Chu Bingfeng , Shao Ningsheng 
Published: July 2017

AbstractGADD45A (growth arrest and DNA damage inducible alpha), a stress response gene induced by genotoxic and nongenotoxic stresses, is implicated in various key processes, including the control of cell cycle checkpoints and DNA repair. The expression of GADD45A is directly regulated by numerous transcription factors, with p53 being the most representative. Moreover, post-transcriptional regulation also plays a role in GADD45A expression. However, little is known about the regulatory effects of microRNAs (miRNAs) on GADD45A expression. As a potential tumour suppressor, miR-138 has pleiotropic biological functions in various cancers. We have previously reported p53-mediated activation of miR-138 in human non-small-cell lung cancer (NSCLC) cells. In this study, we found that miR-138 specifically targeted AGO2, which affects the stability and maturation of miR-130b. Decreased expression of miR-130b promoted the expression of GADD45A and resulted in the G2/M phase arrest and proliferation inhibition in human NSCLC cells. Our results suggested that p53 could alternatively upregulate GADD45A in human NSCLC cells through a post-transcriptional pathway in which miR-138 is involved.
Dynamics of levitated objects in acoustic vortex fields
Authors: Hong Z. Y. , Yin J. F. , Zhai W. , Yan N. , Wang W. L. , Zhang J. , Drinkwater Bruce W. 
Published: July 2017

AbstractAcoustic levitation in gaseous media provides a tool to process solid and liquid materials without the presence of surfaces such as container walls and hence has been used widely in chemical analysis, high-temperature processing, drop dynamics and bioreactors. To date high-density objects can only be acoustically levitated in simple standing-wave fields. Here we demonstrate the ability of a small number of peripherally placed sources to generate acoustic vortex fields and stably levitate a wide range of liquid and solid objects. The forces exerted by these acoustic vortex fields on a levitated water droplet are observed to cause a controllable deformation of the droplet and/or oscillation along the vortex axis. Orbital angular momentum transfer is also shown to rotate a levitated object rapidly and the rate of rotation can be controlled by the source amplitude. We expect this research can increase the diversity of acoustic levitation and expand the application of acoustic vortices.
Persistent current in 2D topological superconductors
Authors: Karnaukhov Igor N. 
Published: July 2017

AbstractA junction between two boundaries of a topological superconductor (TSC), mediated by localized edge modes of Majorana fermions, is investigated. The tunneling of fermions across the junction depends on the magnetic flux. It breaks the time-reversal symmetry at the boundary of the sample. The persistent current is determined by the emergence of Majorana edge modes. The structure of the edge modes depends on the magnitude of the tunneling amplitude across the junction. It is shown that there are two different regimes, which correspond to strong and weak tunneling of Majorana fermions, distinctive in the persistent current behavior. In a strong tunneling regime, the fermion parity of edge modes is not conserved and the persistent current is a 2π-periodic function of the magnetic flux. When the tunneling is weak the chiral Majorana states, which are propagating along the edges have the same fermion parity. They form a 4π-phase periodic persistent current along the boundaries. The regions in the space of parameters, which correspond to the emergence of 2π- and of 4π-harmonics, are numerically determined. The peculiarities in the persistent current behavior are studied.
Metal oxide nanostructures by a simple hot water treatment
Authors: Saadi Nawzat S. , Hassan Laylan B. , Karabacak Tansel 
Published: July 2017

AbstractSurfaces with metal oxide nanostructures have gained considerable interest in applications such as sensors, detectors, energy harvesting cells, and batteries. However, conventional fabrication techniques suffer from challenges that hinder wide and effective applications of such surfaces. Most of the metal oxide nanostructure synthesis methods are costly, complicated, non-scalable, environmentally hazardous, or applicable to only certain few materials. Therefore, it is crucial to develop a simple metal oxide nanostructure fabrication method that can overcome all these limitations and pave the way to the industrial application of such surfaces. Here, we demonstrate that a wide variety of metals can form metal oxide nanostructures on their surfaces after simply interacting with hot water. This method, what we call hot water treatment, offers the ability to grow metal oxide nanostructures on most of the metals in the periodic table, their compounds, or alloys by a one-step, scalable, low-cost, and eco-friendly process. In addition, our findings reveal that a “plugging” mechanism along with surface diffusion is critical in the formation of such nanostructures. This work is believed to be of importance especially for researchers working on the growth of metal oxide nanostructures and their application in functional devices.
Intergenerational Transmission of Paternal Epigenetic Marks: Mechanisms Influencing Susceptibility to Post-Concussion Symptomology in a Rodent Model
Authors: Hehar Harleen , Ma Irene , Mychasiuk Richelle 
Published: July 2017

AbstractEpigenetic transmission of phenotypic variance has been linked to paternal experiences prior to conception and during perinatal development. Previous reports indicate that paternal experiences increase phenotypic heterogeneity and may contribute to offspring susceptibility to post-concussive symptomology. This study sought to determine if epigenetic tags, specifically DNA methylation of promoter regions, are transmitted from rodent fathers to their sons. Using MethyLight, promoter methylation of specific genes involved in recovery from concussion and brain plasticity were analyzed in sperm and brain tissue. Promoter methylation in sperm differed based on paternal experience. Differences in methylation were often identified in both the sperm and brain tissue obtained from their sons, demonstrating transmission of epigenetic tags. For certain genes, methylation in the sperm was altered following a concussion suggesting that a history of brain injury may influence paternal transmission of traits. As telomere length is paternally inherited and linked to neurological health, this study examined paternally derived differences in telomere length, in both sperm and brain. Telomere length was consistent between fathers and their sons, and between brain and sperm, with the exception of the older fathers. Older fathers exhibited increased sperm telomere length, which was not evident in sperm or brain of their sons.
Dual feeding cavity resonator for efficiency enhancement in liquid heating applications
Authors: Abduljabar A.A. , Choi H. , Porch A. 
Published: July 2017

A new type of microwave resonator feeding topology is proposed to enhance the power delivered to a lossy sample for microwave heating applications. The method uses two input signals with equal phase and magnitude, instead of the usual one input. As a result, for the same total input power, the delivered power can be increased to twice the power than the case of the one input. A 2.45 GHz TM010 cylindrical cavity with dual input ports is used to heat a water sample with a total input power of 0.25 W. The efficacy of the proposed heating topology was verified by 3D electromagnetic simulation and heating measurements, including S‐parameters, incident and reflected power, and thermal images. All measurement results support the increase in heating efficiency in the two port case, while using the same total amount of power as for the one port case.
Ocular Involvement in Sarcoidosis
Authors: Rothova Aniki , Groen Fahriye 
Published: July 2017

AbstractOcular involvement in sarcoidosis occurs in ∼40% and the eye is the presenting organ in roughly 20%. The course of ocular disease does not necessarily parallel that of systemic disease. Uveitis is the most common presentation and shows mainly a chronic course; anterior uveitis is associated with better visual prognosis than posterior localization. Painful bilateral anterior granulomatous uveitis most commonly occurs in black patients at younger age, while painless posterior bilateral involvement with peripheral multifocal choroiditis is commonly seen in elderly white females. Patients with posterior uveitis develop often ocular complications and central nervous system involvement. Vitritis, segmental periphlebitis, choroidal granulomas, and peripheral multifocal chorioretinitis are often seen clinical features. Optic nerve involvement is uncommon, but if present, results often in poor visual outcome. Lacrimal gland and conjunctival involvement are also common and present clinically as dry eyes or remain asymptomatic with good visual prognosis. Sarcoidosis-associated uveitis is mostly managed by local treatment with steroid drops or periocular and intraocular steroid injections or with novel intraocular corticosteroid implants. Patients with sight-threatening disease or optic nerve involvement need systemic therapy. Systemic therapy is based on a step-up regimen where corticosteroids are used in the initial phase of the disease and if long-term treatment is required, steroid-sparing immunomodulatory drugs are implemented such as methotrexate or biological agents. Despite the mainly chronic course, need for long-term treatment, and frequent ocular surgeries in the majority of patients, the visual outcome of sarcoidosis-associated uveitis is fairly good if therapy has started on time.
Etiology and Immunopathogenesis of Sarcoidosis: Novel Insights
Authors: Veltkamp Marcel , Meek Bob , Moller David , Beijer Els 
Published: July 2017

AbstractSarcoidosis is a disorder of unknown etiology. It is a systemic disease, frequently involving the lungs, skin, eyes, and lymph nodes. It is characterized by formation of noncaseating granulomas at the site(s) of disease. Sarcoidosis has a complex disease pathogenesis, with involvement of both the innate and adaptive immune systems. Several innate immune system receptors including NOD-like receptors and Toll-like receptors appear to be involved in the development of sarcoidosis as well as cellular players such as dendritic cells and macrophages. Furthermore, lymphocytes from the adaptive immune system including Th1, Th17, regulatory T cells, and B cells are likely to play a role in the sarcoidosis disease pathogenesis as well. Possibly, genetic susceptibility and exposure to particular etiologic agents including mycobacterial and propionibacterial antigens, metals, and silica can cause sarcoidosis. Besides exogenous triggers, also self-compounds such as serum amyloid A and vimentin, have been found to play a role in the development of sarcoidosis. It is likely that sarcoidosis does not have one single cause but rather is the result of the interplay between different etiologic agents and the immune system in predisposed individuals.
Endovascular Stroke Therapy
Authors: Caganap Scott , Smith Wade 
Published: July 2017

AbstractAcute ischemic stroke therapy has rapidly evolved over the past two decades. Recently, a paradigm shift has occurred in the treatment of acute ischemic stroke due to large vessel occlusion with the publication of several randomized trials proving that mechanical thrombectomy with stent retriever devices improves clinical outcome in comparison to intravenous thrombolysis. Furthermore, pooled data from the clinical trials suggest that mechanical thrombectomy can improve outcome in a broad range of patients, and that the sooner the intervention can be performed, the greater the benefit. Delays in endovascular stroke therapy can occur during multiple time points during a patient's encounter, and these time delays are associated with worse outcomes. This association emphasizes the importance of enhancing speed-of-care processes in patients undergoing endovascular reperfusion. Efforts to reduce time delays in endovascular stroke treatment can be achieved by reflecting on the health care initiatives that took place for the treatment of acute myocardial infarction almost 20 years ago. The ideal system of care to reduce delays in endovascular stroke therapy will likely include rapid transport of all eligible patients directly to the angiography suite to bypass the inefficiencies of workflow during the early inhospital setting. These strategies will undoubtedly take time to implement, as they require further research, infrastructure funding, and policy changes at local, regional, and national levels.
Gastrointestinal Bleed from a Left Ventricle to Colonic Interposition Graft Fistula following an Esophagectomy
Authors: Al Khalifa Abdulwahab , McMaster William , Schieman Colin , Whitlock Richard , Ricci Christopher , Danter Matthew 
Published: July 2017

AbstractColonic interposition grafts are commonly used as an esophageal conduit following esophageal resection. Significant morbidity is associated with this reconstruction due to the nature of the operation. Many of the complications associated with this procedure have clear management strategies; however, there is a paucity of data when it comes to managing rare complications. In this report, we discuss the presentation, operative intervention, and postoperative care of a patient who presented with a left ventricle to esophageal colonic interposition graft fistula.
Emerging Therapeutic Strategies in the Treatment of Hemophilia A
Authors: Christophe Olivier , Denis Cécile , Lenting Peter , Muczynski Vincent 
Published: July 2017

AbstractThe development of therapeutic strategies for the treatment of hemophilia A has been a long-lasting issue since the initial identification of the disease in the early 19th century and has involved several major steps to reach contemporary treatment. The current replacement therapy involving intravenous infusion of plasmatic or recombinant factor VIII (FVIII) has been efficient to control bleeding episodes of patients with hemophilia A. Nonetheless, replacement therapy requires frequent infusions to maintain values of FVIII above the threshold of efficacy and represents a serious burden that significantly impacts the patient's quality of life. The recent half-life extension technologies have permitted the development of a first generation of long-acting FVIII variants with improved circulating survival. These molecules, which are now in clinical phase III studies or have already received food and drug administration (FDA) approval for therapeutic use will allow a reduction in the frequency of infusion and lighten the treatment of hemophilia A. However, the half-life extension of FVIII was not as efficient as initially expected, particularly with regard to the results obtained with other therapeutic molecules. To overcome these limitations inherent to the nature of FVIII biology, several bypassing therapies independent of the FVIII molecule are currently in development. These emerging approaches exploit the modulation of the coagulation/anticoagulation balance taking place in the hemostatic process to compensate for the FVIII deficiency. In this review, we recount the history of hemophilia A treatment up to the recent emerging therapies, with particular focus on infusion-based strategies.