bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community’s experiential knowledge on the development of rural tourism competitive advantage: a study on Kampung Semadang – Borneo Heights, Sarawak
Authors: Chin Chee Hua , Thian Susan Su-Zhuang , Lo May Chiun 
Published: May 2017

PurposeRural tourism has emerged as one of the potential economic contributors to the country’s economic growth. To this extent, tourism stakeholders are aware of the rural tourism destination competitiveness where the development should be aligned with the objectives to achieve destination competitive advantage. Given the importance of studying factors that contribute to the development of rural tourism competitive advantage, the present study aimed to propose a research framework by identifying six predictors from the local community based on their experiential knowledge.Design/methodology/approachData were gathered through a structured questionnaire survey where 144 respondents comprising local communities from Kampung Semadang – Borneo Heights, Sarawak, Malaysia – were involved. To assess the developed model, SmartPLS 2.0 (M3) was applied based on path modelling (measurement model assessment) followed by bootstrapping analysis (structural model assessment).FindingsInterestingly, the findings revealed that the communities believed economic, socio-cultural and environmental impacts significantly contributes to the development of rural tourism competitive advantage. Additionally, communities from Kampung Semadang viewed that both community knowledge and support for tourism greatly affect the development of rural tourism destination competitive advantage. Surprisingly, there was no significant relationship between stakeholder involvement and rural tourism competitive advantage.Practical implicationsFrom a practical point of view, the findings of the study provide valuable information to tourism stakeholders and policy planners about the importance of tri-dimensional tourism impacts, as well as community knowledge and support in the development of rural tourism destination competitive advantage. In line with policy development or planning for rural tourism development, the tourism stakeholders should pay more concern on the tri-dimensional impacts, the importance of community knowledge about tourism and gaining the community support for tourism development to achieve the goal of competitiveness.Originality/valueThere is lack of study in investigating the development of rural tourism competitive advantage with a holistic framework. This paper studies the intended or unintended economic, socio-cultural and environmental impacts triggered by the tourism activities. This study has also investigated the local communities’ knowledge and supports toward tourism as the community efforts determine the success of a destination management, especially in the rural area. Stakeholder involvement was also examined as the collaboration among relevant parties to create competitive advantage is essential to achieve sustainable rural tourism.
Characteristics and consequences of falls among older adult trauma patients: Considerations for injury prevention programs
Authors: Chippendale Tracy , Gentile Patricia A. , James Melissa K. 
Published: May 2017

Background/aimHealth promotion and prevention is an important component of occupational therapy practice. Falls are one of the most common causes ofERvisits among older adults and injurious falls requiring trauma care can have a significant impact on the health and quality of life of elders. The aim of this study was to compare characteristics and consequences of falls among older adult trauma patients across different age groups with an eye towards informing injury prevention programs.MethodsA retrospective study using the trauma database from a level one trauma centre in the U.S. (N = 711) was conducted. We compared patient and fall characteristics across age groups and then used logistic regression to estimate odds ratios for hospital length of stay >4 days, discharge disposition, and injury severity (ISS>15).ResultsAssociations between age group and fall height, location and alcohol use at the time of the fall were statistically significant (P < 0.0001). As compared to the reference group (85 and older), younger age groups had lower odds ratios for discharge to a facility for rehabilitation.ConclusionResults highlight differences among age groups of fallers admitted for trauma care and can help to inform injury prevention programs related to outdoor and indoor falls.
A Decision Tree for Nonmetric Sex Assessment from the Skull
Authors: Langley Natalie R. , Dudzik Beatrix , Cloutier Alesia 
Published: May 2017

AbstractThis study uses five well‐documented cranial nonmetric traits (glabella, mastoid process, mental eminence, supraorbital margin, and nuchal crest) and one additional trait (zygomatic extension) to develop a validated decision tree for sex assessment. The decision tree was built and cross‐validated on a sample of 293 U.S. White individuals from the William M. Bass Donated Skeletal Collection. Ordinal scores from the six traits were analyzed using the partition modeling option in JMP Pro 12. A holdout sample of 50 skulls was used to test the model. The most accurate decision tree includes three variables: glabella, zygomatic extension, and mastoid process. This decision tree yielded 93.5% accuracy on the training sample, 94% on the cross‐validated sample, and 96% on a holdout validation sample. Linear weighted kappa statistics indicate acceptable agreement among observers for these variables. Mental eminence should be avoided, and definitions and figures should be referenced carefully to score nonmetric traits.
An Incidental Diffuse Midline Glioma Found at Autopsy
Authors: Walsh Meggen , Hamilton William , Casler Vektra , Yachnis Anthony 
Published: May 2017

AbstractThis case shows an unexpected midline glioma found at autopsy. Two siblings were riding on a single bicycle on the side of a road. The 13‐year‐old brother was seated and steering the bicycle, while the 14‐year‐old sister held onto the back. The bicycle veered left into traffic and was struck by a vehicle. The siblings were admitted to the local Level 1 trauma center, but both later succumbed to injuries. Autopsies were performed on the children, including brains for neuropathologic evaluation. The brother was found to have an infiltrating astrocytoma located in the left middle cerebellar peduncle, with extension to the pons and medulla. His hospital course included several imaging studies using CT and MRI modalities. However, this lesion was not identified until the postmortem neuropathologic examination. This rare case shows the continued need for postmortem autopsy and the current limitations of medical imaging.
Deguelin inhibits epithelial‐to‐mesenchymal transition and metastasis of human non‐small cell lung cancer cells by regulating NIMA‐related kinase 2
Authors: Zhao Dejian , Han Wenzheng , Liu Xia , Cui Dawei , Chen Yu 
Published: May 2017

BackgroundNon‐small cell lung cancer is a lethal malignancy with a high mortality rate. Deguelin displays an anti‐tumor effect and inhibits metastasis in various cancers. The aberrant expression of NIMA‐related kinase 2 (NEK2) indicates poor prognosis and induces epithelial‐to‐mesenchymal transition (EMT) and metastasis processes. However, the underlying mechanism between deguelin and NEK2 has remained elusive.Methods
NSCLC cell lines were treated with deguelin. Wound‐healing and invasion assays were applied to study the inhibitory effect of deguelin on NSCLC cells. EMT markers, E‐cadherin and Vimentin, were also detected by Western blot. NEK2 protein and messenger RNA expression levels were evaluated when NSCLC cells were treated with different concentrations of deguelin. The effect of NEK2 on NSCLC cell metastasis was evaluated through NEK2 knockdown. To investigate whether deguelin induced EMT by regulating NEK2, we overexpressed NEK2 in both NCI‐H520 and SK‐MES‐1 cell lines, and then used real time‐PCR to study the E‐cadherin and Vimentin messenger RNA expression in both NSCLC cells.ResultsDeguelin inhibited migration and invasion processes in NSCLC cell lines and decreased NEK2 expression in a concentration‐dependent manner. Furthermore, NEK2 knockdown inhibited NSCLC cell migration and invasion. Finally, overexpressing NEK2 in NCI‐H520 and SK‐MES‐1 cells could restore the inhibition of metastasis induced by deguelin.ConclusionsDeguelin could inhibit EMT and metastasis, while overexpression of NEK2 promotes these processes. Deguelin could decrease NEK2 expression, while NEK2 overexpression could restore deguelin‐induced inhibition of metastasis.
Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
Authors: Zhang Baozhu , Li Mengqing , Huang Pinzhu , Guan Xin‐Yuan , Zhu Ying‐Hui 
Published: May 2017

BackgroundUbiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC).Methods
USP14 expression was detected in ESCC tissues and matched adjacent non‐tumorous tissues by quantitative real‐time reverse transcription‐PCR and immunohistochemistry. Kaplan–Meier survival analysis was used to assess the correlation between USP14 expression and prognosis in ESCC patients. Univariate and multivariate analysis was conducted with a Cox proportional hazards model to determine whether USP14 is an independent prognostic factor.ResultOverexpression of USP14 was observed in approximately 60% of tested ESCC samples compared to their paired non‐tumor esophageal tissues at both RNA and protein levels, and was significantly associated with distant metastasis (P = 0.001). Kaplan–Meier analysis showed that USP14 overexpression was related to poorer overall patient survival. Univariate and multivariate analyses demonstrated that USP14 was an independent risk factor for overall survival.ConclusionThe findings in this study suggest that USP14 could be used as a potential prognostic marker for ESCC patients.
Detecting selection signatures between Duroc and Duroc synthetic pig populations using high‐density SNP chip
Authors: Edea Z. , Hong J.‐K. , Jung J.‐H. , Kim D.‐W. , Kim Y.‐M. , Kim E.‐S. , Shin S. S. , Jung Y. C. , Kim K.‐S. 
Published: May 2017

SummaryThe development of high throughput genotyping techniques has facilitated the identification of selection signatures of pigs. The detection of genomic selection signals in a population subjected to differential selection pressures may provide insights into the genes associated with economically and biologically important traits. To identify genomic regions under selection, we genotyped 488 Duroc (D) pigs and 155 D × Korean native pigs (DKNPs) using the Porcine SNP70K BeadChip. By applying the FST and extended haplotype homozygosity (EHH‐Rsb) methods, we detected genes under directional selection associated with growth/stature (DOCK7, PLCB4, HS2ST1, FBP2 and TG), carcass and meat quality (TG, COL14A1, FBXO5, NR3C1, SNX7, ARHGAP26 and DPYD), number of teats (LOC100153159 and LRRC1), pigmentation (MME) and ear morphology (SOX5), which are all mostly near or at fixation. These results could be a basis for investigating the underlying mutations associated with observed phenotypic variation. Validation using genome‐wide association analysis would also facilitate the inclusion of some of these markers in genetic evaluation programs.
Elevated maternal placental protein 13 serum levels at term of pregnancy in postpartum major hemorrhage (>1000 mLs). A prospective cohort study
Authors: Farina Antonio , Bernabini Dalila , Zucchini Cinzia , De Sanctis Paola , Quezada Maria Soledad , Mattioli Mara , Rizzo Nicola 
Published: May 2017

ProblemTo compare placental protein 13 (PP13) levels in the serum of women with primary postpartum hemorrhage (PPH) with a control population.MethodsA prospective cohort study was conducted between May 2014 and May 2016 and included 435 pregnant women at term (38 weeks gestation) without any known risk factor and with normal labor. Multiples of median (MoM) were used to evaluate differences of the PP13 values between cases and controls. PP13 concentrations were adjusted for maternal and neonatal weight. Multivariable analysis was used to detect independent contribution of predictors of PPH.ResultsFifteen had a major PPH >1000 mLs and represented the cases of the study. They were matched with 399 controls. Twenty‐one patients who had a minor PPH (500‐1000 mLs) were excluded. The mean observed rank in the PPH group was higher than that of controls (28.5 vs 13.5, P‐value=.01). PP13 MoM values adjusted for maternal weight were higher than expected being 1.44±0.45 in PPH cases and 1.00±0.59 in controls (P‐value .008). This difference was still significant even after adjustment for neonatal weight that represented a confounding variable.ConclusionHigher PP13 levels are independently associated with major PPH >1000 mLs.
Initial observation of CIN2 does not appear to reduce quality of life in women under 25 years of age
Authors: Taghavi Katayoun , Morell Sára , Lamb Jillian , MacNab Helene , Innes Carrie , Coffey Kate , Williman Jonathan , Simcock Bryony , Sykes Peter 
Published: May 2017

BackgroundAlthough the patient perspective is implicit in the practice of medicine, research evaluating this remains scarce. In a climate where clinicians and policy‐makers constantly strive to achieve more patient‐centred models of care, this omission warrants attention.AimTo assess health‐related quality of life (HrQoL) in women under 25 years of age with cervical intra‐epithelial neoplasia grade 2 (CIN2) receiving conservative management (colposcopy follow‐up, with treatment if necessary) compared with those receiving immediate excisional treatment with large loop excision of the transformation zone (LLETZ).MethodsAn observational study evaluating HrQoL was conducted at Christchurch Women's Hospital, New Zealand. Women undergoing conservative management for CIN2 were compared with those undergoing immediate excisional treatment in an age‐matched sample. The Short Form Health Survey 12 version 2 (SF‐12v2) was used to evaluate HrQoL. Secondary outcomes of anxiety and sexual function were also assessed.ResultsOne hundred and four women with CIN2 participated in the study. Of these, 63 (60%) received conservative management and 41 (40%) received immediate excisional treatment with LLETZ. We found no significant difference in HrQoL between the groups in a multivariate regression analysis adjusted for parity, smoking and socioeconomic status. There were also no significant differences in sexual function or anxiety.ConclusionWe found no difference in HrQoL by management strategy. Conservative management of CIN2 in women under 25 is unlikely to have an adverse impact on self‐reported HrQoL, anxiety or sexual functioning compared with conventional management.
Cervical cerclage placed before 14 weeks gestation in women with one previous midtrimester loss: A population‐based cohort study
Authors: Harpham Margaret E. , Algert Charles S. , Roberts Christine L. , Ford Jane B. , Shand Antonia W. 
Published: May 2017

BackgroundCervical cerclage is used in an attempt to reduce recurrence risk of preterm birth, but evidence for use is limited.AimsTo compare pregnancy outcomes among women with a single previous midtrimester delivery when managed with or without a cervical cerclage.Materials and methodsPopulation‐based cohort study of all women in New South Wales, Australia with a singleton pregnancy ending in birth/miscarriage ≥14 and <28 weeks, between 2003 and 2011. Modified Poisson regression was used to compare outcomes in the next subsequent pregnancy, for women with a cerclage inserted <14 weeks, and those without cerclage. The primary outcome was gestational age <37 weeks at birth/miscarriage in the next pregnancy. Secondary outcomes included: maternal morbidity, preterm prelabour rupture of membranes (PPROM), stillbirth/neonatal death and composite neonatal morbidity for liveborn infants ≥28 weeks. Adjusted risk ratios (ARR) and 95% confidence intervals (CI) were determined.ResultsFive thousand, six hundred and ninety‐eight births/miscarriages were potential index deliveries. Of these, 2175 women had an eligible subsequent pregnancy: 108 received cerclage at <14 weeks gestation, 2067 did not. Women with cerclage were significantly more likely to deliver <37 weeks than those without (39.8% vs 19.3%, ARR 1.92, 95% CI 1.48–2.48), and had increased risks of PPROM (ARR 4.38, 95% CI 2.62–7.32) and stillbirth/neonatal death (ARR 2.20, 95% CI 1.02–4.73). Following cerclage, liveborn infants ≥28 weeks had double the risk of severe morbidity (ARR 2.54, 95% CI 1.55–4.16).ConclusionsIn women with a single previous midtrimester delivery, cervical cerclage <14 weeks gestation in subsequent pregnancy was associated with worse pregnancy outcomes.
INTERACTION TERMS IN POISSON AND LOG LINEAR REGRESSION MODELS
Authors: Shang Shengwu , Nesson Erik , Fan Maoyong 
Published: May 2017

ABSTRACTThis paper develops a difference‐in‐semielasticities (DIS) interpretation for the coefficients of dichotomous variable interaction terms in nonlinear models with exponential conditional mean functions, including but not limited to Poisson, Negative Binomial, and log linear models. We show why these interaction term coefficients cannot be interpreted as a DIS or semielasticity in the same manner as continuous coefficients, which has been overlooked by some empirical researchers. Then we show how interaction terms can be easily transformed into a DIS and derive the asymptotic distribution of this estimator. We illustrate the discrepancy between the interaction term coefficient and the DIS using an empirical example evaluating the relationship between employment, private health insurance and physician office visits. Our results can be applied in treatment effect models when the outcome variable is logged and the dichotomous variables indicating treatment participation and the post‐treatment time period.
Absenteeism in Head Start and Children's Academic Learning
Authors: Ansari Arya , Purtell Kelly M. 
Published: May 2017

Using nationally representative data from the Family and Child Experiences Survey 2009 cohort (n = 2,842), this study examined the implications of 3‐ and 4‐year‐old's absences from Head Start for their early academic learning. The findings from this study revealed that children who missed more days of school, and especially those who were chronically absent, demonstrated fewer gains in areas of math and literacy during the preschool year. Moreover, excessive absenteeism was found to detract from the potential benefits of quality preschool education and was especially problematic for the early learning of children who entered the Head Start program with a less developed skill set. Implications for policy and practice are discussed.
Three‐Year‐Olds’ Reactions to a Partner's Failure to Perform Her Role in a Joint Commitment
Authors: Kachel Ulrike , Svetlova Margarita , Tomasello Michael 
Published: May 2017

When children make a joint commitment to collaborate, obligations are created. Pairs of 3‐year‐old children (N = 144) made a joint commitment to play a game. In three different conditions the game was interrupted in the middle either because: (a) the partner child intentionally defected, (b) the partner child was ignorant about how to play, or (c) the apparatus broke. The subject child reacted differently in the three cases, protesting normatively against defection (with emotional arousal and later tattling), teaching when the partner seemed to be ignorant, or simply blaming the apparatus when it broke. These results suggest that 3‐year‐old children are competent in making appropriate normative evaluations of intentions and obligations of collaborative partners.
Look At That! Video Chat and Joint Visual Attention Development Among Babies and Toddlers
Authors: McClure Elisabeth R. , Chentsova‐Dutton Yulia E. , Holochwost Steven J. , Parrott W. G. , Barr Rachel 
Published: May 2017

Although many relatives use video chat to keep in touch with toddlers, key features of adult–toddler interaction like joint visual attention (JVA) may be compromised in this context. In this study, 25 families with a child between 6 and 24 months were observed using video chat at home with geographically separated grandparents. We define two types of screen‐mediated JVA (across‐ and within‐screen) and report age‐related increases in the babies’ across‐screen JVA initiations, and that family JVA usage was positively related to babies’ overall attention during video calls. Babies today are immersed in a digital world where formative relationships are often mediated by a screen. Implications for both infant social development and developmental research are discussed.
Extra oral digital scanning and imaging superimposition for volume analysis of bone remodeling after tooth extraction with and without 2 types of particulate porcine mineral insertion: A randomized controlled trial
Authors: Barone Antonio , Toti Paolo , Menchini‐Fabris Giovan‐Battista , Derchi Giacomo , Marconcini Simone , Covani Ugo 
Published: May 2017

AbstractBackgroundIncorporation of bone substitute material into the extraction socket could minimize the edentulous ridge volume loss or maximize the bone formation within the healing area.PurposeThe aim of the study was to test the effectiveness in maintaining the volumetric contour of fresh extraction sockets grafted with or without 2 types of porcine biomaterials and covered with a resorbable barrier.Materials and MethodsIn the present multi‐center single‐blind randomized control trial, 55 patients underwent 1‐tooth extraction, were surveyed, and randomly allocated to control‐ (25 sites, nat‐group) or test groups (15 sites grafted with pre‐hydrated collagenated cortico‐cancellous porcine bone, coll‐group, and 15 with cortical porcine bone, cort‐group). Before extraction, and then 4 months later, contours of the sockets were acquired through a laser scanner, voxelized, and ghosts of each patient were superimposed with a matrix laboratory. Volumetric and area evaluations of the virtual superimposed models were performed with dentascan tools to create a volume of interest extending between the 2 residual teeth. Intra‐ and inter‐group comparisons of the outcomes were performed. Non‐parametric tests were applied with a level of significance set at P < .05.ResultsIntergroup analysis at 4 months' survey revealed that percentage loss of alveolar ridge volume of the coll‐group (28.8% ± 8.8%) and of the cort‐group (30.2% ± 7.1%) was significantly lower (P < .0001) than that of the naturally‐healing group (46.4% ± 4.1%). No statistically‐significant differences in outcomes were observed between the 2 test groups at any of the observation periods. Moreover, tooth position (bicuspids vs molars) seemed to affect neither volume loss nor basal shrinkage.ConclusionAt the 4‐month analysis both test groups showed reduced bone loss when compared to naturally healing sockets. However, the 2 grafting materials were not able to preserve the alveolar crest, and a reduction close to 30% in the estimates was registered after healing.