bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army
Authors: Ko Henry , Hunter KE , Scott AM , Ayson M , Willson ML 
Published: August 2017

IntroductionIn 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel.MethodsSearches for studies examining biotechnological and pharmacological products in Army populations were conducted in December 2015. Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and PsycINFO were searched without date or language restrictions. WHO’s International Clinical Trials Registry Platform and ClinicalTrials.gov were searched to identify ongoing trials. Studies meeting inclusion criteria were evaluated for risk of bias using Cochrane’s Risk of Bias tool. Due to heterogeneity of findings, meta-analysis could not be conducted. Findings were synthesised narratively and by vote-counting method.ResultsSixteen pharmacological enhancement products were evaluated in 22 randomised controlled trials (RCTs), involving 1284 personnel. Only three of the studies were published since 2010. The interventions evaluated were varied, including supplements (eg, carbohydrate), stimulants (eg, caffeine) and hormones (eg, melatonin). Generally, caffeine provided an improvement in performance compared with placebo on 5/7 reported cognitive outcomes, followed by levothyroxine (four cognitive outcomes) and prazosin (three cognitive outcomes). Performance results were mixed (finding an improvement and no effect in comparison to placebo) for caffeine and melatonin on two outcomes. No evidence was found pertaining to biotechnological products. Studies rarely reported safety outcomes (eg, adverse events and addiction).ConclusionFindings from this review need to be interpreted with considerable caution. Future studies should include outcomes such as acute and long-term adverse events, and should evaluate cognitive performance using cognitive tests that are specific to the Army population.
Retrospective analysis of four-year injury data from the Infantry Training Centre, Catterick
Authors: Heagerty Robert , Sharma J , Cayton J , Goodwin N 
Published: August 2017

IntroductionMusculoskeletal injury (MSKI) represents a considerable threat to the effectiveness and productivity of military organisations globally. The impact on the medical chain, occupational disposal with associated loss of working days and associated financial burden have far-reaching consequence. The moral and legal responsibility to reduce avoidable injuries through risk assessment and prevention strategies is fundamental to governance and a key component of best practice.MethodsA retrospective observational analysis was performed of 4101 MSKIs presenting from a total inflow of 10 498 British Army Infantry recruits recorded over four consecutive training years between 2012 and 2016. Injury incidence, site, type and week of training were recorded and analysed.ResultsThe total incidence of all MSKI was observed as 39.1%. Overuse injuries were the most common subclassification of injury type (24.5%), followed by trauma (8.8%) and then stress fractures (5.7%). Causes of medical discharge over a four-year cumulative incidence were from overuse injuries (59.3%), stress fractures (21.5%) and trauma (19.2%). 45.5% of all MSKIs presented within the first eight weeks of training.ConclusionsMSKI data highlighted the requirement for a comprehensive service evaluation of the Combat Infantryman’s Course and subsequent justification for the introduction of an injury prevention intervention — Project OMEGA.
Single particle energies and nuclear g factors
Authors: Robinson Shadow , Zamick Larry 
Published: August 2017

Adding one neutron to doubly magic [Formula: see text]Sn, we can associate the low lying states in[Formula: see text]Sn with single particle states. Thus, the [Formula: see text] and [Formula: see text] states are identified as the [Formula: see text] and [Formula: see text] single particle states, respectively. In [Formula: see text]Sn, these two low lying states are separated by an energy of 0.172[Formula: see text]MeV. Currently, there is a dispute as to the ordering of these states. We examine how the two scenarios, selecting [Formula: see text] as the ground state or [Formula: see text] as the ground state, affect spectra and nuclear [Formula: see text] factors of higher mass Sn isotopes in a variety of shell model situations. Significantly, this includes examining the complex interplay of the choice of single particle state splitting, effective interactions, and effective [Formula: see text]-factors in nuclear shell model calculations. Of particular importance is how the trends in the calculated results for [Formula: see text] factors diverge from recent experimental measurements for the higher mass isotopes of Sn.
Tectonic implications of the lithospheric structure across the Barents and Kara shelves
Authors: Faleide Jan Inge , Pease Victoria , Curtis Mike , Klitzke Peter , Minakov Alexander , Scheck-Wenderoth Magdalena , Kostyuchenko Sergei , Zayonchek Andrei 
Published: August 2017

Abstract
This paper considers the lithospheric structure and evolution of the wider Barents–Kara Sea region based on the compilation and integration of geophysical and geological data. Regional transects are constructed at both crustal and lithospheric scales based on the available data and a regional three-dimensional model. The transects, which extend onshore and into the deep oceanic basins, are used to link deep and shallow structures and processes, as well as to link offshore and onshore areas. The study area has been affected by numerous orogenic events in the Precambrian–Cambrian (Timanian), Silurian–Devonian (Caledonian), latest Devonian–earliest Carboniferous (Ellesmerian–Svalbardian), Carboniferous–Permian (Uralian), Late Triassic (Taimyr, Pai Khoi and Novaya Zemlya) and Palaeogene (Spitsbergen–Eurekan). It has also been affected by at least three episodes of regional-scale magmatism, the so-called large igneous provinces: the Siberian Traps (Permian–Triassic transition), the High Arctic Large Igneous Province (Early Cretaceous) and the North Atlantic (Paleocene–Eocene transition). Additional magmatic events occurred in parts of the study area in Devonian and Late Cretaceous times. Within this geological framework, we integrate basin development with regional tectonic events and summarize the stages in basin evolution. We further discuss the timing, causes and implications of basin evolution. Fault activity is related to regional stress regimes and the reactivation of pre-existing basement structures. Regional uplift/subsidence events are discussed in a source-to-sink context and are related to their regional tectonic and palaeogeographical settings.
Ocean forced variability of Totten Glacier mass loss
Authors: Roberts Jason , Galton-Fenzi Benjamin K. , Paolo Fernando S. , Donnelly Claire , Gwyther David E. , Padman Laurie , Young Duncan , Warner Roland , Greenbaum Jamin , Fricker Helen A. , Payne Antony J. , Cornford Stephen , Le Brocq Anne , van Ommen Tas , Blankenship Don , Siegert Martin J. 
Published: August 2017

Abstract

A large volume of the East Antarctic Ice Sheet drains through the Totten Glacier (TG) and is thought to be a potential source of substantial global sea-level rise over the coming centuries. We show that the surface velocity and height of the floating part of the TG, which buttresses the grounded component, have varied substantially over two decades (1989–2011), with variations in surface height strongly anti-correlated with simulated basal melt rates (
r
= 0.70,
p
< 0.05). Coupled glacier–ice shelf simulations confirm that ice flow and thickness respond to both basal melting of the ice shelf and grounding on bed obstacles. We conclude the observed variability of the TG is primarily ocean-driven. Ocean warming in this region will lead to enhanced ice-sheet dynamism and loss of upstream grounded ice.
Algorithm 983
Authors: Fahmy Thierry , Bellétoile Arnaud 
Published: August 2017

The detection of heterogeneity among objects (products, treatments, medical studies) assessed on a series of blocks (consumers, patients, methods, pathologists) is critical in numerous areas such as clinical research, cosmetic studies, or survey analysis. The Cochran’s
Q
test is the most widely used test for identifying heterogeneity on binary data (success vs. failure, cure vs. not cure, 1 vs. 0, etc.). For a large number of blocks, the
Q
distribution can be approximated by a χ
2
distribution. Unfortunately, this does not hold for limited sample sizes or sparse tables. In such situations, one has to either run
Monte Carlo
simulations or compute the exact
Q
distribution to obtain an accurate and reliable result. However, the latter method is often disregarded in favor of the former due to computational expense considerations. The purpose of this article is to propose an extremely fast implementation of the exact Cochran’s
Q
test so one can benefit from its accuracy at virtually no cost regarding computation time. It is implemented as a part of the XLSTAT statistical software (Addinsoft 2015). After a short presentation of the Cochran’s
Q
test and the motivation for its exact version, we detail our approach and present its actual implementation. We then demonstrate the gain of this algorithm with performance evaluations and measurements. Comparisons against a well-established implementation have shown an increase of the computational velocity by a factor ranging from 100 up to 1× 10
6
in the most favorable cases.
Ventilation and neurochemical changes during µ-opioid receptor activation or blockade of excitatory receptors in the hypoglossal motor nucleus of goats
Authors: Langer Thomas M. , Neumueller Suzanne E. , Crumley Emma , Burgraff Nicholas J. , Talwar Sawan , Hodges Matthew R. , Pan Lawrence , Forster Hubert V. 
Published: August 2017

Neuromodulator interdependence posits that changes in one or more neuromodulators are compensated by changes in other modulators to maintain stability in the respiratory control network. Herein, we studied compensatory neuromodulation in the hypoglossal motor nucleus (HMN) after chronic implantation of microtubules unilaterally ( n = 5) or bilaterally ( n = 5) into the HMN. After recovery, receptor agonists or antagonists in mock cerebrospinal fluid (mCSF) were dialyzed during the awake and non-rapid eye movement (NREM) sleep states. During day studies, dialysis of the µ-opioid inhibitory receptor agonist [d-Ala2, N-MePhe4, Gly-ol]enkephalin (DAMGO; 100 µM) decreased pulmonary ventilation (V̇i), breathing frequency ( f), and genioglossus (GG) muscle activity but did not alter neuromodulators measured in the effluent mCSF. However, neither unilateral dialysis of a broad spectrum muscarinic receptor antagonist (atropine; 50 mM) nor unilateral or bilateral dialysis of a mixture of excitatory receptor antagonists altered V̇i or GG activity, but all of these did increase HMN serotonin (5-HT) levels. Finally, during night studies, DAMGO and excitatory receptor antagonist decreased ventilatory variables during NREM sleep but not during wakefulness. These findings contrast with previous dialysis studies in the ventral respiratory column (VRC) where unilateral DAMGO or atropine dialysis had no effects on breathing and bilateral DAMGO or unilateral atropine increased V̇i and f and decreased GABA or increased 5-HT, respectively. Thus we conclude that the mechanisms of compensatory neuromodulation are less robust in the HMN than in the VRC under physiological conditions in adult goats, possibly because of site differences in the underlying mechanisms governing neuromodulator release and consequently neuronal activity, and/or responsiveness of receptors to compensatory neuromodulators. NEW & NOTEWORTHY Activation of inhibitory µ-opioid receptors in the hypoglossal motor nucleus decreased ventilation under physiological conditions and did not affect neurochemicals in effluent dialyzed mock cerebral spinal fluid. These findings contrast with studies in the ventral respiratory column where unilateral [d-Ala2, N-MePhe4, Gly-ol]enkephalin (DAMGO) had no effects on ventilation and bilateral DAMGO or unilateral atropine increased ventilation and decreased GABA or increased serotonin, respectively. Our data support the hypothesis that mechanisms that govern local compensatory neuromodulation within the brain stem are site specific under physiological conditions.
The physiology of oral whistling: a combined radiographic and MRI analysis
Authors: Azola Alba , Palmer Jeffrey , Mulheren Rachel , Hofer Riccardo , Fischmeister Florian , Fitch W. Tecumseh 
Published: August 2017

The fluid mechanics of whistling involve the instability of an air jet, resultant vortex rings, and the interaction of these rings with rigid boundaries (see http://www.canal-u.tv/video/cerimes/etude_radiocinematographique_d_un_siffleur_turc_de_kuskoy.13056 and Meyer J. Whistled Languages. Berlin, Germany: Springer, 2015, p. 74–774). Experimental models support the hypothesis that the sound in human whistling is generated by a Helmholtz resonator, suggesting that the oral cavity acts as a resonant chamber bounded by two orifices, posteriorly by raising the tongue to the hard palate, and anteriorly by pursed lips (Henrywood RH, Agarwal A. Phys Fluids 25: 107101, 2013). However, the detailed anatomical changes in the vocal tract and their relation to the frequencies generated have not been described in the literature. In this study, videofluoroscopic and simultaneous audio recordings were made of subjects whistling with the bilabial (i.e., “puckered lip”) technique. One whistling subject was also recorded, using magnetic resonance imaging. As predicted by theory, the frequency of sound generated decreased as the size of the resonant cavity increased; this relationship was preserved throughout various whistling tasks and was consistent across subjects. Changes in the size of the resonant cavity were primarily modulated by tongue position rather than jaw opening and closing. Additionally, when high-frequency notes were produced, lateral chambers formed in the buccal space. These results provide the first dynamic anatomical evidence concerning the acoustic production of human whistling. NEW & NOTEWORTHY We establish a new and much firmer quantitative and physiological footing to current theoretical models on human whistling. We also document a novel lateral airflow mechanism used by both of our participants to produce high-frequency notes.
Distinct coordinate systems for adaptations of movement direction and extent
Authors: Poh Eugene , Carroll Timothy J. , de Rugy Aymar 
Published: August 2017

Learned compensations for perturbed visual feedback of movement extent and direction generalize differently to unpracticed movement directions, which suggests different underlying neural mechanisms. Here we investigated whether gain and rotation adaptations are consistent with representation in different coordinate systems. Subjects performed a force-aiming task with the wrist and learned different gains or rotations for different force directions. Generalization was tested without visual feedback for the same extrinsic directions but with the forearm in a different pronation-supination orientation. When the change in forearm orientation caused the adapted visuomotor map to conflict in extrinsic and joint-based coordinates, rotation generalization occurred in extrinsic coordinates but with reduced magnitude. In contrast, gain generalization appeared reduced and phase shifted. When the forearm was rotated further, such that all imposed perturbations aligned in both joint-based and extrinsic coordinates in both postures, rotation generalization was further reduced, whereas there was neither reduction nor phase shift in the pattern of extent generalization. These results show that rotation generalization was expressed in extrinsic coordinates, and that generalization magnitude was modulated by posture. In contrast, gain generalization appeared to depend on target direction defined by an integrated combination of extrinsic and joint-based coordinates and was not reduced substantially by posture changes alone. Although the quality of the model fit underlying our interpretation prevents us from making strong conclusions, the data suggest that adaptations of movement direction and extent are represented according to distinct coordinate systems.NEW & NOTEWORTHY Visuomotor gain and rotation adaptations generalize differently to novel movement directions, which suggests different neural mechanisms. When extrinsic and joint-based coordinates are effectively dissociated in an isometric aiming task, we find that they also generalize in different coordinate systems. Specifically, rotation generalized in extrinsic coordinates and decayed as posture departed from that adopted during adaptation. In contrast, gain generalization was expressed according to mixed extrinsic/joint-based coordinates and was not substantially reduced by postural changes.
Vowel generalization and its relation to adaptation during perturbations of auditory feedback
Authors: Reilly Kevin J. , Pettibone Chelsea 
Published: August 2017

Repeated perturbations of auditory feedback during vowel production elicit changes not only in the production of the perturbed vowel (adaptation) but also in the production of nearby vowels that were not perturbed (generalization). The finding that adaptation generalizes to other, nonperturbed vowels suggests that sensorimotor representations for vowels are not independent; instead, the goals for producing any one vowel may depend in part on the goals for other vowels. The present study investigated the dependence or independence of vowel representations by evaluating adaptation and generalization in two groups of speakers exposed to auditory perturbations of their first formant (F1) during different vowels. The speakers in both groups who adapted to the perturbation exhibited generalization in two nonperturbed vowels that were produced under masking noise. Correlation testing was performed to evaluate the relations between adaptation and generalization as well as between the generalization in the two nonperturbed vowels. These tests identified significant coupling between the F1 changes of adjacent vowels but not nonadjacent vowels. The pattern of correlation findings indicates that generalization was due in part to feedforward representations that are partly shared across adjacent vowels, possibly to maintain their acoustic contrast.NEW & NOTEWORTHY Speech adaptations to alterations, or perturbations, of auditory feedback have provided important insights into sensorimotor representations underlying speech. One finding from these studies that is yet to be accounted for is vowel generalization, which describes the effects of repeated perturbations to one vowel on the production of other vowels that were not perturbed. The present study used correlation testing to quantify the effects of changes in a perturbed vowel on neighboring (i.e., similar) nonperturbed vowels. The results identified significant correlations between the changes of adjacent, but not nonadjacent, vowel pairs. This finding suggests that generalization is partly a response to adaptation and not solely due to the auditory perturbation.
EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL
Authors: Brach Dorothy , Johnston-Blackwell Danielle , Drew Allison , Lingaraj Trupti , Motwani Vinny , Warholic Natalie M. , Feldman Igor , Plescia Christopher , Smith Jesse J. , Copeland Robert A. , Keilhack Heike , Chan-Penebre Elayne , Knutson Sarah K. , Ribich Scott A. , Raimondi Alejandra , Thomenius Michael J. 
Published: August 2017

Abstract
The EZH2 small-molecule inhibitor tazemetostat (EPZ-6438) is currently being evaluated in phase II clinical trials for the treatment of non-Hodgkin lymphoma (NHL). We have previously shown that EZH2 inhibitors display an antiproliferative effect in multiple preclinical models of NHL, and that models bearing gain-of-function mutations in EZH2 were consistently more sensitive to EZH2 inhibition than lymphomas with wild-type (WT) EZH2. Here, we demonstrate that cell lines bearing EZH2 mutations show a cytotoxic response, while cell lines with WT-EZH2 show a cytostatic response and only tumor growth inhibition without regression in a xenograft model. Previous work has demonstrated that cotreatment with tazemetostat and glucocorticoid receptor agonists lead to a synergistic antiproliferative effect in both mutant and wild-type backgrounds, which may provide clues to the mechanism of action of EZH2 inhibition in WT-EZH2 models. Multiple agents that inhibit the B-cell receptor pathway (e.g., ibrutinib) were found to have synergistic benefit when combined with tazemetostat in both mutant and WT-EZH2 backgrounds of diffuse large B-cell lymphomas (DLBCL). The relationship between B-cell activation and EZH2 inhibition is consistent with the proposed role of EZH2 in B-cell maturation. To further support this, we observe that cell lines treated with tazemetostat show an increase in the B-cell maturation regulator, PRDM1/BLIMP1, and gene signatures corresponding to more advanced stages of maturation. These findings suggest that EZH2 inhibition in both mutant and wild-type backgrounds leads to increased B-cell maturation and a greater dependence on B-cell activation signaling. Mol Cancer Ther; 16(11); 2586–97. ©2017 AACR.
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells
Authors: Wang Hao-Chen , Chen Chin-Wang , Yang Chia-Lung , Tsai I-Min , Hou Ya-Chin , Chen Chang-Jung , Shan Yan-Shen 
Published: August 2017

Abstract
Epigenetic repression of the tumor suppressor gelsolin (GSN) is frequently observed in cancers. Chronic inflammation can promote tumor progression via aberrant DNA methylation. In this study, we investigated the role of tumor-associated macrophages (TAMs) in DNA methylation of the GSN gene during gastric cancer progression. Immunofluorescence staining of 121 gastric cancer tissues showed aberrant localization of GSN and DNA methyltransferase 1 (DNMT1) and juxtaposition of DNMT1 and M2 TAMs. Decreased GSN protein and mRNA expression and increased DNA methylation in the GSN promoter were observed in gastric cancer cell lines and clinical specimens. To examine the effect of TAMs on DNA methylation in gastric cancer cells, we performed in vitro coculture assays and found increased DNMT1 expression but decreased GSN expression in gastric cancer cells after coculture with U937 cells. Knockdown of DNMT1 expression in gastric cancer cells could abort U937 coculture-mediated GSN downregulation. Meanwhile, CCL5 was the main chemokine upregulated in coculture medium. Treatment with CCL5 could induce DNMT1 expression in gastric cancer cells via STAT3 signaling. Inhibiting DNMT1 activity with procainamide, inhibiting DNA methylation with 5-AZA, or inhibiting CCL5/CCR5 signaling with maraviroc reduced tumor growth in vivo. In conclusion, upregulation of DNMT1 by CCL5/CCR5/STAT3 signaling is critical for TAM-mediated GSN silencing in gastric cancer. This study identified potential targets for gastric cancer therapy. Cancer Immunol Res; 5(10); 885–97. ©2017 AACR.