bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energetic requirements and mechanistic plasticity in Msp1-mediated substrate extraction from lipid bilayers
Authors: Smith Baylee , Gaur Deepika , Walker Nathan , Walter Isabella , Wohlever Matthew L. 
Published: September 2024

AbstractAAA+ proteins are essential molecular motors involved in numerous cellular processes, yet their mechanism of action in extracting membrane proteins from lipid bilayers remains poorly understood. One roadblock for mechanistic studies is the inability to generate subunit specific mutations within these hexameric proteins. Using the mitochondrial AAA+ protein Msp1 as a model, we created covalently linked dimers with varying combinations of wild type and catalytically inactive E193Q mutations. The wide range of ATPase rates in these constructs allows us to probe how Msp1 uses the energy from ATP hydrolysis to perform the thermodynamically unfavorable task of removing a transmembrane helix (TMH) from a lipid bilayer. Ourin vitroandin vivoassays reveal a non-linear relationship between ATP hydrolysis and membrane protein extraction, suggesting a minimum ATP hydrolysis rate is required for effective TMH extraction. While structural data often supports a sequential clockwise/2-residue step (SC/2R) mechanism for ATP hydrolysis, our biochemical evidence suggests mechanistic plasticity in how Msp1 coordinates ATP hydrolysis between subunits, potentially allowing for robustness in processing challenging substrates. This study enhances our understanding of how Msp1 coordinates ATP hydrolysis to drive mechanical work and provides foundational insights about the minimum energetic requirements for TMH extraction and the coordination of ATP hydrolysis in AAA+ proteins.
Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool
Authors: Meader Eleanor , Walcheck Morgan T. , Leder Mindy R. , Jing Ran , Wrighton Paul J. , Sugden Wade W. , Najia Mohamad A. , Oderberg Isaac M. , Taylor Vivian M. , LeBlanc Zachary C. , Quenzer Eleanor D. , Lim Sung-Eun , Daley George Q. , Goessling Wolfram , North Trista E. 
Published: September 2024

SUMMARYEmbryonic hematopoietic stem and progenitor cells (HSPCs) have the unique ability to undergo rapid proliferation while maintaining multipotency, a clinically-valuable quality which currently cannot be replicated in vitro. Here, we show that embryonic HSPCs achieve this state by precise spatio-temporal regulation of reactive oxygen species (ROS) via Bnip3lb-associated developmentally-programmed mitophagy, a distinct autophagic regulatory mechanism from that of adult HSPCs. While ROS drives HSPC specification in the dorsal aorta, scRNAseq and live-imaging ofTg(ubi:mitoQC)zebrafish indicate that mitophagy initiates as HSPCs undergo endothelial-to-hematopoietic transition and colonize the caudal hematopoietic tissue (CHT). Knockdown ofbnip3lbreduced mitophagy and HSPC numbers in the CHT by promoting myeloid-biased differentiation and apoptosis, which was rescued by anti-oxidant exposure. Conversely, induction of mitophagy enhanced both embryonic HSPC and lymphoid progenitor numbers. Significantly, mitophagy activation improved ex vivo functional capacity of hematopoietic progenitors derived from human-induced pluripotent stem cells (hiPSCs), enhancing serial-replating hematopoietic colony forming potential.HIGHLIGHTSROS promotes HSPC formation in the dorsal aorta but negatively affects maintenance thereafter.HSPCs colonizing secondary niches control ROS levels via Bnip3lb-directed mitophagy.Mitophagy protects nascent HSPCs from ROS-associated apoptosis and maintains multipotency.Induction of mitophagy enhances long-term hematopoietic potential of iPSC-derived HSPCs.
Charge distributions of pseudoscalar and vector mesons from Dyson-Schwinger equations
Authors: Xu Y.-Z. , Raya K. , Rodríguez-Quintero J. , Segovia J. 
Published: September 2024

We combine the Dyson-Schwinger/Bethe-Salpeter equations framework with modern numerical reconstruction methods to derive the three-dimensional and transverse two-dimensional charge distribution of an array of ground-state pseudoscalar and vector mesons from their elastic electromagnetic form factor in the low-momentum region. The charge radii obtained by averaging over the reconstructed charge distributions have been checked to be consistent with those calculated from the slope of the elastic electromagnetic form factor at zero transferred momentum. The capability of the reconstruction procedure for capturing a reliable low-distance charge distribution is discussed and argued to work down to distances of around 0.1 fm, such that it might be potentially applied to extract, e.g., mass densities from gravitational form factors.

Published by the American Physical Society
2024
Triply charm and bottom tetraquarks in a constituent quark model
Authors: Yang Gang , Ping Jialun , Segovia Jorge 
Published: September 2024

Singly, doubly, and fully charmed tetraquark candidates, e.g., Tcs¯(2900), Tcc+(3875), and X(6900) have been recently reported by the LHCb collaboration. Therefore, it is timely to implement a theoretical investigation on triply heavy tetraquark systems; herein, the S-wave triply charm and bottom tetraquarks, Q¯Qq¯Q (q=u,d,s;Q=c,b), with spin-parity JP=0+, 1+, and 2+, isospin I=0 and 12, are systematically studied in a constituent quark model. Besides, all tetraquark configurations, i.e., meson-meson, diquark-antidiquark, and K-type arrangements, along with any allowed color structure, are comprehensively considered. The Gaussian expansion method (GEM), in combination with the complex-scaling method (CSM), which is quite ingenious in dealing with either bound or resonances, is the approach adopted in solving the complex scaled Schrödinger equation. This theoretical framework has already been applied in various tetra- and pentaquark systems. In a fully coupled-channel calculation within the GEM+CSM, narrow resonances are found in each I(JP) channel of the charm and bottom sector. In particular, triply charm and bottom tetraquark resonances are obtained in 5.6–5.9 GeV and 15.3–15.7 GeV, respectively. We provide also some insights of the compositeness of these exotic states, such as the inner quark distance, magnetic moment and dominant wave function component. All this may help to distinguish them in future high energy nuclear and particle experiments.

Published by the American Physical Society
2024
Thermal effects on sound velocity peak and conformality in isospin QCD
Authors: Chiba Ryuji , Kojo Toru , Suenaga Daiki 
Published: September 2024

We study thermal effects on equations of state (EOS) in isospin QCD, utilizing a quark-meson model coupled to a Polyakov loop. The quark-meson model is analyzed at one-loop that is the minimal order to include quark substructure constraints on pions which condense at finite isospin density. In the previous study we showed that the quark-meson model at zero temperature produces the sound velocity peak and the negative trace anomaly in the domain between the chiral effective theory regime at low density and the perturbative QCD regime at high density, in reasonable agreement with lattice simulations. We now include thermal effects from quarks in the Polyakov loop background and examine EOS, especially the sound velocity and trace anomaly along isentropic trajectories. At large isospin density, there are three temperature windows; (i) the pion condensed region with almost vanishing Polyakov loops, (ii) the pion condensed region with finite Polyakov loops, and (iii) the quark gas without pion condensates. In the domain (i), the gap associated with the pion condensate strongly quenches thermal excitations. As the system approaches the domain (ii), thermal quarks, which behave as nonrelativistic particles, add energy density but little pressure, substantially reducing the sound velocity to the value less than the conformal value while increasing the trace anomaly toward the positive value. Approaching the domain (iii), thermal quarks become more relativistic as pion condensates melt, increasing sound velocity toward the conformal limit. Corrections from thermal pions are also briefly discussed.

Published by the American Physical Society
2024
Experiences of autistic people in supported employment in France: a participatory research project
Authors: Dachez Julie , Seksek Sylvie , Ete Natacha , Bianciotto Marc , Toubhans Marie-Pierre , Rachedi Nasri Zineb , Bureau Raven , Garnier Philippe 
Published: September 2024

PurposeThe employment rate of autistic people is low, and they are often employed in low-paying jobs or in jobs involving tasks that fall short of their skills and competence. To address this situation, the individual placement and support method (IPS) offers promising perspectives for personalized and long-term support measures. This evidence-based method has produced positive results in several countries. IPS has been used in France only since 2016. This paper aims to examine the experience of autistic people in France who have benefitted from supported employment measures.Design/methodology/approachNineteen autistic adults in France took part in semistructured interviews. Interview questions focused on work and measures to support employment. The authors analysed the interviews using reflexive thematic analysis, within the paradigm of critical realism. The authors adopted a participatory approach; the project was led by an autistic researcher and autistic individuals were included at all stages.FindingsThis study identified six primary themes and three subthemes across the data: (1) The uphill battle to obtain adjustments in the workplace; (2) insufficient knowledge of autism; (2.1) explaining again and again: the educative burden; (3) the challenge of making oneself heard; (3.1) when the entourage steps in; (4) support measures as material assistance and reassurance; (4.1) between benevolence and condescension; (5) organizational factors that affect the quality of support; and (6) personal and professional life are closely intertwined.Originality/valueThis research provides a better understanding of how autistic people experience supported employment in France and highlights ways to improve it. Job coaches play a crucial role in offering practical help and reassurance, and their efforts to nurture an active personal life are perceived positively. However, supported employment also carries the risk of limiting autistic individuals' capacity for action and causing several difficulties if job coaches are not well-informed about autism, do not reflect on their own attitudes, do not assist in obtaining necessary accommodations and if there are organizational problems leading to a lack of resources.
How management support and diversity factors affect employee performance within the digital workplace
Authors: Grzesiak Lena , Ulrych Wojciech 
Published: September 2024

PurposeWe aimed to determine how remote management support (MS) practices and staff diversity influenced employee performance (EP) within the digital workplace (DW) during the COVID-19 pandemic. The article highlights the challenges managers face in achieving EP in the DW compared to traditional work environments.Design/methodology/approachWe developed a theoretical model (MS→DW→EP) and tested it based on the computer-assisted web interview (CAWI) conducted in mid-2022. Factors of primary, secondary and organizational diversity moderated the relationship between the variables. We purposely selected a sample of 1,000 respondents with remote working experience.FindingsThe results show that the DW partially mediates the relationship between MS and EP. The greater the uncertainty in managing people, the more flexibility, trust and job satisfaction required in the DW to achieve EP. Organizational diversity influenced the model more (i.e. teamwork vs individual work) than the primary and secondary diversity (i.e. gender and education).Research limitations/implicationsAlthough the sample size was large, we cannot consider it statistically representative.Practical implicationsZoomers and Millennials reflect full mediation in the model that supports EP.Social implicationsBroader work autonomy, smaller organizations and teams as well as hybrid work arrangements, reduce the necessity for in-person meetings with superiors.Originality/valueSupervisors had to reduce control over the DW while expanding organizational citizenship behavior (OCB) to enhance job satisfaction and thus ensure the expected EP during the pandemic. We may consider allowing an employee to postpone work as a new managerial activity within MS.
Moving toward employees' flourishing-at-work, an Indian perspective
Authors: Peethambaran Meera , Naim Mohammad Faraz 
Published: September 2024

PurposeThis study explores the pivotal relationship between humble leadership (HL) and flourishing-at-work (FAW) in the context of the information technology-enabled services (ITes) industry. Specifically, it explores the mediating role of psychological empowerment (PE) and the moderating influence of proactive personality (PP) in this dynamic interplay.Design/methodology/approachData from a comprehensive survey of 342 full-time employees from information technology-enabled services (ITes) organizations in India were meticulously analyzed. Utilizing covariance-based structural equation modeling (CB-SEM) in IBM AMOS 21.0.FindingsThe results illuminate the positive impact of HL on PE, subsequently enhancing FAW among employees. Furthermore, PE was identified as a partial mediator in the relationship between HL and FAW. Intriguingly, this mediation process was found to be significantly stronger when employees exhibited a higher degree of proactive personality.Practical implicationsThis research underscores the critical importance of cultivating humble leadership within organizations. The findings emphasize the potential of targeted training programs aimed at nurturing humble leadership qualities among managerial staff. By doing so, organizations can significantly contribute to the emotional, psychological and social well-being of their employees, ultimately fostering a state of FAW.Originality/valueThis research innovatively links the concepts of humble leadership and FAW within the specific context of the ITes industry. By integrating PE as a mediator and PP as a moderator, this study not only fills a critical gap in existing literature but also provides a robust framework for future research.
Detecting dynamic interaction of multiple subjects in policy information communication in China
Authors: Zhou Qingqing , Guan Tianyang 
Published: September 2024

Purpose
As an important part of national governance, the online communication of education policies usually attracts the attention of many subjects, including the public and the media. Existing research mainly focuses on analysing communication behaviour of a single subject. However, with the rapid development of social media, policy information communication is often accompanied by the participation of multiple subjects and forms diversified communication behaviours and interaction patterns. The comprehensive identification of multiple subjects and their interactions can accurately depict the communication process and effectively support the efficient communication of policies. Therefore, this paper aims to conduct fine-grained analysis on the multiple subjects in information communication of the education policy.

Design/methodology/approach
This paper explored the communication and interaction process of the education policy via multidimensional analysis. Specifically, the authors firstly obtained multi-source communication data to identify key communication subjects. Secondly, the authors mined the communication contents generated by communication subjects to measure the diversified correlations between subjects. Finally, the authors depicted the interaction of subjects in policy information communication.

Findings
The experimental results reveal that there are multiple key subjects in the policy information communication, and the communication roles of the subjects change with the communication process, including dominance role, one-way or two-way effect role. This further indicates the need to allocate resources dynamically in the process of policy communication.

Originality/value
Analysing the process of policy communication and identifying the dynamic interaction between communication subjects can provide more a comprehensive and detailed decision-making basis for policy formulation and implementation. In addition, the research ideas and methods presented in this paper expand the perspective of information communication research.
Use of information technologies in lean management: the case of Gazi University Research Center in Turkey
Authors: Tanrıverdi Mustafa , Ceran Onur , Uysal Mevlüt , Üstündağ Mutlu Tahsin 
Published: September 2024

Purpose
Sustainability and accessibility of education are the main purposes of educational institutions. Higher education institutions (HEIs) have been addressing these concerns through their distance education departments for years. Especially during and after the COVID-19 pandemic, HEIs encountered challenges related to productivity, escalating costs and decreasing user satisfaction with distance education. This study proposes the integration of new and suitable information technologies (ITs) into the steps of lean management (LM) implementation. It suggests that this approach will be highly effective and beneficial, providing solutions to the problems above in higher education (HE) field. The study aims to highlight the effectiveness and benefits of incorporating new and suitable ITs into the application stages of LM principles. Sample applications in HE will be provided to enhance understanding.

Design/methodology/approach
A model is introduced for researching new ITs and incorporating appropriate ones in the application steps of LM. This model has been applied and analyzed in two case studies at Gazi University for a more comprehensive understanding.

Findings
When examining periodic surveys and usage statistics from case studies, it becomes evident that implementing LM with the support of ITs reduces waste and enhances the quality of existing work. The success observed in the case studies was notably influenced by managers’ proficiency in business processes, experience in ITs, managerial skills and support from senior management.

Practical implications
This case study provides a roadmap and step-by-step implementation of LM with IT support for HEIs. The implementation process and results will also be guiding for other sectors.

Originality/value
There is a notable absence of significant studies on integrating ITs, which have become crucial in today’s context in the stages of LM implementation. This study is envisioned as a pioneering endeavor to address this gap in the literature. Notably, challenges exist in applying LM principles outside production sectors, and limited research has been conducted. This study aims to pave the way for further research in diverse fields by conducting a comprehensive case study in the realm of HE.
Relationship between body involvement and post-trip behavioral intention in sports tourism: an embodied cognition perspective
Authors: Gao Rujiu , Koh Denise , Wang Ling 
Published: September 2024

PurposeBased on the theory of embodied cognition, this study uses the Mehrabian–Rusell model to explore the influence of tourists’ body involvement during sports vacations on their post-trip behavioral intention, as well as the regulatory role of tourism involvement in this process.Design/methodology/approachStructural equation modeling (SEM) was used to test the hypotheses, mediating effects and moderating effects. The data were collected through an online survey of 631 visitors to sports tourism destinations in China.FindingsProprioception and kinesthesia in sports tourism activities can affect post-trip behavioral intention through body arousal and tourism satisfaction. Tourism involvement positively regulates the influence of body embeddedness and body arousal on tourism satisfaction. Furthermore, a “threshold effect” exists in the emotional effect of tourists’ body involvement.Practical implicationsTo develop sports tourism, it is important to take the following steps: create multi-sensory stimulation to improve the physical participation of tourists in sports tourism activities, design sports resorts that cater to people of different age groups, evaluate tourists’ satisfaction and use their feedback to make continuous improvements, improve the basic convenience services offered at sports resorts, use social media to display the unique physical environment and others characteristics of sports destinations to expand popularity.Originality/valueThis study constructs a conceptual model of the influence mechanism of tourists’ body involvement on post-trip behavioral intention to present valuable insights that could help promote the sustainable development of sports tourism.
Study on the friction loss behavior of a wire rope and liner mating pair interface under vibration conditions
Authors: Luo Zhihao , Guo Yongbo , Cao Yourui , Zhu Zheyingzi , Ma Wan , Wang Songquan , Zhang Dekun 
Published: September 2024

Purpose
This study aims to study the influence of friction influencing factors between the wire rope and the liner on the safe use of the wire rope, which can provide guidance for the reliability design of the lifting system with strong dynamic response such as high speed, heavy load, etc., and improve the friction-driven stability of the system.

Design/methodology/approach
In this paper, the friction mechanism of wire rope and liner under the condition of excitation is investigated by means of wire rope-liner friction-vibration experimental platform and dynamic viscoelastic test of liner.

Findings
The results show that: With increasing excitation frequency, the friction between the three liner materials (G30, K25, PU) and the wire rope decreased, and the wear of the surface shape of the liners was greater. The dynamic thermomechanical analysis (DMA) test results showed that the viscoelasticity of the three liner materials increased when the frequency was increased.

Research limitations/implications
Wire ropes are widely used in deep shaft hoisting and building elevators. Its operational reliability depends on whether there is sufficient friction between the wire rope and the friction liner, and whether the friction liner has good wear resistance. The study of the friction between the wire rope and the liner influencing factors is of great significance for the safe service of the wire rope.

Practical implications
The related results can provide guidance for the reliability design of lifting systems with strong dynamic response, such as high speed and heavy load, to improve the friction drive stability of the system.

Originality/value
With the increase of mining depth, to improve the transportation efficiency of the hoist used in deep and ultra-deep mines, as well as to ensure the safety and reliability of its operation, it is crucial that the large friction hoisting equipment has sufficient friction between the wire rope and the friction lining, as well as whether the friction lining has a good abrasion resistance.