bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer
Authors: Rutten Iris J.G. , Ubachs Jorne , Kruitwagen Roy F.P.M. , Beets‐Tan Regina G.H. , Olde Damink Steven W.M. , Van Gorp Toon 
Published: May 2017

AbstractBackgroundComputed tomography measurements of total skeletal muscle area can detect changes and predict overall survival (OS) in patients with advanced ovarian cancer. This study investigates whether assessment of psoas muscle area reflects total muscle area and can be used to assess sarcopenia in ovarian cancer patients.MethodsOvarian cancer patients (n = 150) treated with induction chemotherapy and interval debulking were enrolled retrospectively in this longitudinal study. Muscle was measured cross sectionally with computed tomography in three ways: (i) software quantification of total skeletal muscle area (SMA); (ii) software quantification of psoas muscle area (PA); and (iii) manual measurement of length and width of the psoas muscle to derive the psoas surface area (PLW). Pearson correlation between the different methods was studied. Patients were divided into two groups based on the extent of change in muscle area, and agreement was measured with kappa coefficients. Cox‐regression was used to test predictors for OS.ResultsCorrelation between SMA and both psoas muscle area measurements was poor (r = 0.52 and 0.39 for PA and PLW, respectively). After categorizing patients into muscle loss or gain, kappa agreement was also poor for all comparisons (all κ < 0.40). In regression analysis, SMA loss was predictive of poor OS (hazard ratio 1.698 (95%CI 1.038–2.778), P = 0.035). No relationship with OS was seen for PA or PLW loss.ConclusionsChange in psoas muscle area is not representative of total muscle area change and should not be used to substitute total skeletal muscle to predict survival in patients with ovarian cancer.
Long‐term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study
Authors: Jang Jin‐Young , Kang Jae Seung , Han Youngmin , Heo Jin Seok , Choi Seong Ho , Choi Dong Wook , Park Sang Jae , Han Sung‐Sik , Yoon Dong Sup , Park Joon Seong , Yu Hee Chul , Kang Koo Jeong , Kim Sang Geol , Lee Hongeun , Kwon Wooil , Yoon Yoo‐Seok , Han Ho‐Seong , Kim Sun‐Whe 
Published: May 2017

AbstractBackgroundOur previous randomized controlled trial revealed no difference in 2‐year overall survival (OS) between extended and standard resection for pancreatic adenocarcinoma. The present study evaluated the 5‐year OS and recurrence patterns according to the extent of pancreatectomy.MethodsBetween 2006 and 2009, 169 consecutive patients were prospectively enrolled and randomized to standard (n = 83) or extended resection (n = 86) groups to compare 5‐year OS rate, long‐term recurrence patterns and factors associated with long‐term survival.ResultsThe surgical R0 rate was similar between the standard and extended groups (85.5 vs. 90.7%, P = 0.300). Five‐year OS (18.4 vs. 14.4%, P = 0.388), 5‐year disease‐free survival (14.8 vs. 14.0%, P = 0.531), and overall recurrence rates (74.7 vs. 69.9%, P = 0.497) were not significantly different between the two groups, although the incidence of peritoneal seeding was higher in the extended group (25 vs. 8.1%, P = 0.014).ConclusionsExtended pancreatectomy does not have better short‐term and long‐term survival outcomes, and shows similar R0 rates and overall recurrence rates compared with standard pancreatectomy. Extended pancreatectomy does not have to be performed routinely for all cases of resectable pancreatic adenocarcinoma, especially considering its associated increased morbidity shown in our previous study.
Patient reported outcomes in orthopaedics
Authors: Gagnier Joel J. 
Published: May 2017

ABSTRACTPatient reported outcome measures (PROMs) are key tools when performing clinical research and PROM data are increasingly used to inform clinical decision‐making, patient‐centered care, health policy and more recently, reimbursement decisions. PROMs must possess particular properties before they are used. Thus purpose of this paper is to give an overview of PROMs, their definition, how their evidence can be assessed, how they should be reported in clinical research, how to choose PROMs, the types of PROMs available in orthopaedics, where these measures can be found, PROMs in orthopaedic clinical practice and what are some key next steps in this field. If PROMs are used in accordance with the guidance in this article, I believe we will gain considerable insight into PROMs in orthopaedics and will advance this field in a way that can contribute to science, improve patient care and save considerable resources. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2098–2108, 2017.
Mechanically induced bone formation is not sensitive to local osteocyte density in rat vertebral cancellous bone
Authors: Cresswell Erin N. , Nguyen Thu M. , Horsfield Michael W. , Alepuz Adrian J. , Metzger Thomas A. , Niebur Glen L. , Hernandez Christopher J. 
Published: May 2017

ABSTRACTOsteocytes play an integral role in bone by sensing mechanical stimuli and releasing signaling factors that direct bone formation. The importance of osteocytes in mechanotransduction suggests that regions of bone tissue with greater osteocyte populations are more responsive to mechanical stimuli. To determine the effects of osteocyte population on bone functional adaptation we applied mechanical loads to the 8th caudal vertebra of skeletally mature female Sprague Dawley rats (6 months of age, n = 8 loaded, n = 8 sham controls). The distribution of tissue stress/strain within cancellous bone was determined using high‐resolution finite element models, osteocyte distribution was determined using nano‐computed tomography, and locations of bone formation were determined using three‐dimensional images of fluorescent bone formation markers. Loading increased bone formation (3D MS/BS 10.82 ± 2.09% in loaded v. 3.17 ± 2.05% in sham control, mean ± SD). Bone formation occurred at regions of cancellous bone experiencing greater tissue stress/strain, however stress/strain was only a modest predictor of bone formation; even at locations of greatest stress/strain the probability of observing bone formation did not exceed 41%. The local osteocyte population was not correlated with locations of new bone formation. The findings support the idea that local tissue stress/strain influence the locations of bone formation in cancellous bone, but suggest that the size of the osteocyte population itself is not influential. We conclude that other aspects of osteocytes such as osteocyte connectivity, lacunocanilicular nano‐geometry, and/or fluid pressure/shear distributions within the marrow space may be more influential in regulating bone mechanotransduction than the number of osteocytes. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:672–681, 2018.
REMSleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies
Authors: St Louis Erik K. , Boeve Angelica R. , Boeve Bradley F. 
Published: May 2017

ABSTRACTRapid eye movement sleep behavior disorder is characterized by dream enactment and complex motor behaviors during rapid eye movement sleep and rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia) during polysomnography. Rapid eye movement sleep behavior disorder may be idiopathic or symptomatic and in both settings is highly associated with synucleinopathy neurodegeneration, especially Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure. Rapid eye movement sleep behavior disorder frequently manifests years to decades prior to overt motor, cognitive, or autonomic impairments as the presenting manifestation of synucleinopathy, along with other subtler prodromal “soft” signs of hyposmia, constipation, and orthostatic hypotension. Between 35% and 91.9% of patients initially diagnosed with idiopathic rapid eye movement sleep behavior disorder at a sleep center later develop a defined neurodegenerative disease. Less is known about the long‐term prognosis of community‐dwelling younger patients, especially women, and rapid eye movement sleep behavior disorder associated with antidepressant medications. Patients with rapid eye movement sleep behavior disorder are frequently prone to sleep‐related injuries and should be treated to prevent injury with either melatonin 3‐12 mg or clonazepam 0.5‐2.0 mg to limit injury potential. Further evidence‐based studies about rapid eye movement sleep behavior disorder are greatly needed, both to enable accurate prognostic prediction of end synucleinopathy phenotypes for individual patients and to support the application of symptomatic and neuroprotective therapies. Rapid eye movement sleep behavior disorder as a prodromal synucleinopathy represents a defined time point at which neuroprotective therapies could potentially be applied for the prevention of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure. © 2017 International Parkinson and Movement Disorder Society
Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats
Authors: Beaumont Martin , Jaoui Daphné , Douard Véronique , Mat Damien , Koeth Fanny , Goustard Bénédicte , Mayeur Camille , Mondot Stanislas , Hovaghimian Anais , Le Feunteun Steven , Chaumontet Catherine , Davila Anne‐Marie , Tomé Daniel , Souchon Isabelle , Michon Camille , Fromentin Gilles , Blachier François , Leclerc Marion 
Published: May 2017

ScopeFew studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. In this study we evaluated in rat the impact of two structures of protein emulsion in food on gut microbiota, luminal content composition, and intestinal characteristics.Methods and resultsRats received for 3 weeks two diets of identical composition but based on lipid‐protein matrices of liquid fine (LFE) or gelled coarse (GCE) emulsion. LFE diet led to higher abundance, when compared to the GCE, of Lactobacillaceae (Lactobacillus reuteri) in the ileum, higher β‐diversity of the caecum mucus‐associated bacteria. In contrast, the LFE diet led to a decrease in Akkermansia municiphila in the caecum. This coincided with heavier caecum content and higher amount of isovalerate in the LFE group. LFE diet induced an increased expression of (i) amino acid transporters in the ileum (ii) glucagon in the caecum, together with an elevated level of GLP‐1 in portal plasma. However, these intestinal effects were not associated with modification of food intake or body weight gain.ConclusionOverall, the structure of protein emulsion in food affects the expression of amino acid transporters and gut peptides concomitantly with modification of the gut microbiota composition and activity. Our data suggest that these effects of the emulsion structure are the result of a modification of protein digestion properties.
Modified rectangular shape patch antennas for ultra‐wide band and notch characteristics response
Authors: Deshmukh Amit A. , Mohadikar Payal V. 
Published: May 2017

AbstractNovel designs of modified rectangular shape printed monopole antenna for Ultra wide band response are proposed, which gives bandwidth across 1GHz–10 GHz range. Further two variations of rectangular shape patches to realize tunable notch characteristics, are also presented. They yield tunable notch characteristics in two different frequency bands. Proposed antennas give broadside radiation pattern with peak gain of 2 dBi.
Wavefront spatial‐phase modulation in visible optical communications
Authors: Sabino João , Figueira Gonçalo , André Paulo 
Published: May 2017

AbstractVisible light communications (VLC) are an essential technology in the future 5G networks. In this article, for the first time to best of our knowledge, we introduce the concept of wavefront spatial‐phase modulation VLC transmission, using spatial light modulators. The implemented system exhibits a signal to noise ratio of 18 dB, with a total capacity higher than 1 Gbaud/s.
Switched beam patch array antenna using SPDT GaN HEMT switches
Authors: Hamdoun Abdelaziz , Himdi Mohammed , Lafond Olivier , Roy Langis 
Published: May 2017

AbstractIn this article, a single‐fed 4‐panel 4 × 1 patch array antenna operating at 2.43 GHz with switched beam capability is proposed. The design allows the beam to be switched between 4 discrete directions giving 360° coverage. The antenna beam is switched over the azimuth plane for Φ = 0°, Φ = 90°, Φ = 180°, and Φ = 270°. The beam control is achieved using GaN‐based HEMT SPDT switches. Only 3 SPDT switches are integrated directly into the structure, allowing its nature to be electrically controlled over the desired 4 directions. Simulated and measured reflection coefficients and radiation patterns for the 4 cases are presented and discussed, showing good agreement. The antenna gain is around 3.8 dB including switches losses at 2.43 GHz.
Differential voltage octuple rectifiers for wireless energy harvesting
Authors: Zeng Miaowang , Li Zihong , Andrenko Andrey S. , Liu Xianluo , Tan Hong‐Zhou 
Published: May 2017

AbstractThis paper presents the design of a novel differential voltage octuple rectifier for wireless RF energy harvesting. Two rectifiers with common matching (CM) and two‐branch matching (TBM) are presented for the CDMA850/GSM900 bands operation. Measured maximum efficiencies of CM and TBM rectifiers reach 66.5% and 70.6%, respectively. The results also show that both matching network‐type rectifiers can produce higher output voltage. It is demonstrated that the designed rectifier‐antenna structure powers up a battery‐less LCD sensor by harvesting RF signal of a dialing cell phone. The proposed rectifier topology and matching mechanisms can be used for various energy harvesting applications, especially for those requiring high supply voltage.
Compact lotus shape dual band patch antenna for Bluetooth and ultra wideband applications
Authors: Samsuzzaman M. , Mahmud M. Z. , Tarikul Islam M. , Ali M. M. , Islam M. T. 
Published: May 2017

AbstractA compact lotus shape dual band microstrip patch antenna is presented in this article. Dual‐band operation for both Bluetooth and ultra wideband (UWB) is covered with low profile, enriched gain, and small size. The lotus shape patch and Sawtooth ground provide smooth impedance bandwidth, and dual band characteristics are achieved. In lower frequency, the antenna cover about 300 MHz from 2.3 to 2.6 GHz (Bluetooth), while in upper frequency, bandwidth is about 7.7 GHz from 3.3 to 12 GHz which covers UWB band. With a dimension of 44 × 42 mm2, the proposed antenna is fed by a microstrip fed line and printed on less expensive FR‐4 substrate. The simulated and measured result of impedance, radiation pattern, gain, and efficiency are fair enough. This antenna shows an omnidirectional radiation pattern across the integrated Bluetooth and UWB bands both theoretically and experimentally. With an excellent impulse response, high fidelity, and quality factor, the proposed antenna is suitable for using dual band frequency of both Bluetooth and UWB without interference between each other.
Compact dual‐band bandpass filters with stub resonating lines
Authors: Abu Safia Ousama , Nedil Mourad , Yagoub Mustapha C. E. , Talbi Larbi , Hettak Khelifa 
Published: May 2017

AbstractSeveral new compact microstrip dual‐band bandpass filters using admittance inverters and open‐ended resonating stubs are introduced. Operating at the center‐band frequencies of 1.8 and 2.4 GHz, with moderate bandwidth passbands, the proposed devices are suitable for LTE mobile cellular networks and Wi‐Fi technologies. The design procedure includes the use of simple equations to extract the lumped element values of the circuit model. Next, the equivalent distributed layout which consists of 3 admittance inverters and 4 shunt‐connected stubs (two λg/2 and two λg/2) is presented. The design is adjusted to attain further enhancement in the electrical and physical characteristics. These include spurious passband suppression, layout miniaturization, and reduction in the capacitive coupling between stubs. Measured responses are compared with simulated results, and very good agreement is observed. These features make the proposed filters suitable for integration into various microwave planar technologies.
A 4.6‐GHz low‐phase‐noise differential common‐gate Clapp VCO with simplified common‐mode biasing
Authors: Din Amad Ud , Nghia Nguyen Tai , Phan Huu Nhan , Nguyen Khac Vu , Lee Jong‐Wook 
Published: May 2017

AbstractWe present a new differential Clapp voltage‐controlled oscillator (VCO) suitable for low‐voltage scaled‐down CMOS technology. For loss compensation, the Clapp VCO uses a common‐gate topology that provides higher transconductance than that of the conventional common‐drain configuration. To provide reliable start‐up condition for the Clapp VCO, a small inductor is added at the gate of a transistor in the common‐gate configuration. The new configuration also simplifies DC biasing while providing a suitable common‐mode point for varactor tuning. All of these features allow the Clapp VCO to operate under low‐voltage and low‐power conditions. The fabricated Clapp VCO using 0.18‐μm RFCMOS achieves an excellent phase noise performance of −121 dBc/Hz at a 1 MHz offset from 4.6 GHz. Under a supply voltage of 1.0 V and a power consumption of 4.2 mW, the figure‐of‐merit (FOM) is −188 dBc/Hz.
An ultra‐wide band diversity antenna with band‐rejection capability for imaging applications
Authors: Latif Farah , Tahir Farooq A. , Khan Muhammad U. , Sharawi Mohammad S. 
Published: May 2017

AbstractIn this paper, a 2‐element UWB‐MIMO antenna system is proposed for imaging applications. Each antenna element consists of semi‐circular slot excited by 50 Ω microstrip transmission lines. Two small stubs are used on both sides of the microstrip lines for better impedance matching at higher frequencies. The band‐rejection at WLAN (5.15–5.825 GHz) band is achieved through a U‐shaped slot in the feeding transmission line. The antenna works efficiently from 3.1 to 10.6 GHz, covering the entire standard UWB. Slots in the ground plane are introduced to improve the isolation level between the antenna elements. A minimum isolation of 20 dB is attained in the entire operating band. The proposed antenna has a size of 58 × 27
. Good agreement is obtained between simulated and measured results for reflection coefficient, isolation and consistent radiation patterns over the entire operating band that makes it promising candidate for medical imaging application in UWB.
Investigation of the self‐imaging position of a singlemode‐multimode‐singlemode optical fiber structure
Authors: Wang Xianfan , Lewis Elfed , Wang Pengfei 
Published: May 2017

AbstractIn this paper, a theoretical and experimental investigation of the multimode interference induced self‐imaging phenomenon in a singlemode‐multimode‐singlemode (SMS) fiber structure is described. The simulated transmission spectra based on guided modal propagation analysis and beam propagation method are presented and compared with experimental obtained results. The temperature dependence of the self‐imaging position of the SMS fiber structure is also investigated. These investigations provide excellent opportunities for multiple future applications including telecommunications and sensing.
A new technique to fabricate cylindrical frequency selective surface using aluminium foil paper
Authors: Sarkar S. , Samaddar P. , Begam N. , Sarkar D. C. , Sarkar P. P. 
Published: May 2017

AbstractThis letter presents a new technique to fabricate aperture type cylindrical frequency selective surface (FSS) with circular, tripole, and plus shaped element. The cylindrical FSSs exhibit band pass property from 5 to 9 GHz, 11.75 to 14.75 GHz, and 7 to 14 GHz, respectively. A novel method with aluminium foil paper is suggested for fabrication. Cylindrical FSS is fabricated with this technique in laboratory with commercially available aluminium foil paper and is measured practically. In this technique, with the help of laser cutting machine 0.01 mm precision label can be achieved. Both simulated and measured results are in good agreement. The aluminium foil paper made FSS proved to be very light weight, flexible and low cost.
Dual feed MIMO cylindrical dielectric resonator antenna with high isolation
Authors: Das Gourab , Sharma Anand , Gangwar Ravi Kumar 
Published: May 2017

AbstractA cylindrical dielectric resonator antenna (CDRA) for multiple‐input multiple‐output (MIMO) applications is examined in this article. Proposed MIMO radiator achieves high isolation by generating orthogonal modes in CDRA with the help of dual feeding techniques, that is, aperture coupling (port‐1) and coplanar waveguide (port‐2) techniques. The fractional bandwidth for both port‐1 and port‐2 is 11.5% (4.9–5.5 GHz). The isolation in operating band between port‐1 and port‐2 exceed more than 32dB. For validating the optimized simulated results, the archetype of proposed MIMO antenna is fabricated and tested. The diversity performance of proposed structure is also examined and experimentally verified. The proposed radiator is found appropriate for 5.2 GHz WLAN application.
A 224–448 MHz low‐power fully integrated phase‐locked loop using 0.18‐μm CMOS process
Authors: Tsai Jeng‐Han , Lin Chia‐Lung , Kuo Yin‐Ting 
Published: May 2017

AbstractA 224‐448 MHz low‐power fully integrated phase‐locked loop (PLL) is designed and implemented in standard 0.18‐μm CMOS process. For wide tuning rage and compact circuit size, a differential ring‐type voltage‐controlled oscillator (VCO) is adopted. The replica bias circuit is added to provide the required voltage for the delay cell of the VCO. For low dc consumption, a high‐speed true single phase clock (TSPC) divider is used. The PLL achieves wide operating frequency from 224 to 448 MHz with low dc power consumption of 2.62 mW from 1.8 V voltage supply. The measured phase noises are −98 and −115 dBc/Hz at 100 kHz and 10 MHz frequency offsets, respectively.
A novel method to realize optical single sideband modulation with tunable optical carrier to sideband ratio
Authors: Peng Zhengxue , Wen Aijun , Gao Yongsheng , Tu Zhaoyang , Chen Wei , Zhang Wu 
Published: May 2017

AbstractAn optical single sideband (OSSB) modulation method with tunable optical carrier to sideband ratio (OCSR) is proposed and experimentally demonstrated based on a dual‐polarization Mach–Zehnder modulator (DPol‐MZM). An orthogonally polarized double sideband (DSB) signal output from the DPol‐MZM is filtered out the carrier and one sideband utilizing an optical bandpass filter (OBPF). Then the orthogonally polarized OSSB signal is transformed into a linear polarized OSSB signal by a polarizer (Pol). By changing the polarization direction of the Pol utilizing a polarization controller (PC), the tunable OCSR can be achieved. In the demonstrated experiments, an OSSB modulation is implemented over the wide microwave frequency range of 5–30 GHz. The OCSR is tuned from −30 dB to infinity. The proposed OSSB modulation method is advantageous in many respects as large tunable OCSR range, wide operation bandwidth, and simple structure.
Spectral efficiency enhancement in SNR‐limited PON system based on SSB 3D modulation
Authors: Kwon Dong‐Woo , Kang Soo‐Min , Park Hyung‐Joon , Han Sang‐Kook 
Published: May 2017

AbstractWe propose a single sideband three‐dimensional modulation technique for a passive optical network which has an insufficient signal‐to‐noise ratio (SNR). We demonstrated a SE improvement of 1.65 times with 3dB lower SNR compared to a conventional quadrature amplitude modulation (QAM) signal.