bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethos: The heart of ethics and health
Authors: Östman Lillemor , Näsman Yvonne , Eriksson Katie , Nyström Lisbet 
Published: March 2017

Background: Ethics in nursing care are traditionally discussed in terms of moral norms or principles. When taking an ontological approach to ethics, ethics is about ethos. Ethos involves both an internal and an external side of ethics. Considering ethics and health from an ontological perspective can provide a different understanding of ethics and health in caring and nursing. Aim and research question: The aim of this study is to deepen the ontological understanding of ethics and health in caring and nursing. The research question is as follows: What is the ontology of health and ethics in caring and nursing? Research design: The study follows a hermeneutical design inspired by Gadamer. Participants and research context: essays about ethics and health were gathered from PhD students in nursing and caring sciences. Ethical considerations: The research follows Responsible conduct of research guidelines provided by the Finnish Advisory Board on Research Integrity. Findings: An ethos with the values of freedom and responsibility seem to ontologically be important for ethics and health. These values allow a movement between the internal and the external sides of ethics that is important for health. Discussion: The ethos of freedom and responsibility that is essential for ethics and health can provide the current ethical debate a new starting point that previous research asks for. Conclusion: Ontologically, an ethos of freedom and responsibility is essential for ethics and health in nursing and caring.
Here and Now Aboriginal Assessment (HANAA): a follow-up survey of users
Authors: Janca Aleksandar , Lyons Zaza , Gaspar Jane 
Published: March 2017

Objectives: To explore users’ views of, and experience with, the Here and Now Aboriginal Assessment (HANAA), an instrument developed for screening social and emotional wellbeing (SEWB) in Aboriginal adults. Over the last few years the HANAA has been widely disseminated across Australia. Methods: All those on our database who had requested the HANAA package were contacted by email and invited to participate in the evaluation by completing an online survey. Results: A total of 38 responses were received; the response rate was 36%. All 10 HANAA domains were highly rated by respondents; the overall mean score was 8.3/10. Each domain was assessed using a dichotomous scale of ‘problem’ or ‘no problem’ which respondents rated as being very useful; the mean score was 8.4/10. The mean score for the ‘recommendation’ section at the end of the HANAA was 7.2/10. Conclusions: Respondents reported a high level of utility and cultural applicability of the HANAA’s assessment domains, semi-structured narrative style of administration and simple rating system. The HANAA is making a useful and practical contribution to the assessment of Aboriginal SEWB at a community level. Recommendations for future work on the HANAA include consideration of addition of a personality domain and development of a child and adolescent version.
Parental evaluation of a telemonitoring service for children with Type 1 Diabetes
Authors: Losiouk E , Lanzola G , Del Favero S , Boscari F , Messori M , Rabbone I , Bonfanti R , Sabbion A , Iafusco D , Schiaffini R , Visentin R , Galasso S , Di Palma F , Chernavvsky D , Magni L , Cobelli C , Bruttomesso D , Quaglini S 
Published: March 2017

Introduction In the past years, we developed a telemonitoring service for young patients affected by Type 1 Diabetes. The service provides data to the clinical staff and offers an important tool to the parents, that are able to oversee in real time their children. The aim of this work was to analyze the parents’ perceived usefulness of the service. Methods The service was tested by the parents of 31 children enrolled in a seven-day clinical trial during a summer camp. To study the parents’ perception we proposed and analyzed two questionnaires. A baseline questionnaire focused on the daily management and implications of their children’s diabetes, while a post-study one measured the perceived benefits of telemonitoring. Questionnaires also included free text comment spaces. Results Analysis of the baseline questionnaires underlined the parents’ suffering and fatigue: 51% of total responses showed a negative tendency and the mean value of the perceived quality of life was 64.13 in a 0–100 scale. In the post-study questionnaires about half of the parents believed in a possible improvement adopting telemonitoring. Moreover, the foreseen improvement in quality of life was significant, increasing from 64.13 to 78.39 ( p-value = 0.0001). The analysis of free text comments highlighted an improvement in mood, and parents’ commitment was also proved by their willingness to pay for the service (median = 200 euro/year). Discussion A high number of parents appreciated the telemonitoring service and were confident that it could improve communication with physicians as well as the family’s own peace of mind.
Testing fine motor coordination via telehealth: Effects of video characteristics on reliability and validity
Authors: Hoenig Helen M , Amis Kristopher , Edmonds Carol , Morgan Michelle S , Landerman Lawrence , Caves Kevin 
Published: March 2017

Background There is limited research about the effects of video quality on the accuracy of assessments of physical function. Methods A repeated measures study design was used to assess reliability and validity of the finger–nose test (FNT) and the finger-tapping test (FTT) carried out with 50 veterans who had impairment in gross and/or fine motor coordination. Videos were scored by expert raters under eight differing conditions, including in-person, high definition video with slow motion review and standard speed videos with varying bit rates and frame rates. Results FTT inter-rater reliability was excellent with slow motion video (ICC 0.98–0.99) and good (ICC 0.59) under the normal speed conditions. Inter-rater reliability for FNT ‘attempts’ was excellent (ICC 0.97–0.99) for all viewing conditions; for FNT ‘misses’ it was good to excellent (ICC 0.89) with slow motion review but substantially worse (ICC 0.44) on the normal speed videos. FTT criterion validity (i.e. compared to slow motion review) was excellent (β = 0.94) for the in-person rater and good ( β = 0.77) on normal speed videos. Criterion validity for FNT ‘attempts’ was excellent under all conditions ( r ≥ 0.97) and for FNT ‘misses’ it was good to excellent under all conditions ( β = 0.61–0.81). Conclusions In general, the inter-rater reliability and validity of the FNT and FTT assessed via video technology is similar to standard clinical practices, but is enhanced with slow motion review and/or higher bit rate.
Organs-on-chips: Progress, challenges, and future directions
Authors: Low Lucie A , Tagle Danilo A 
Published: March 2017

The National Institutes of Health Microphysiological Systems (MPS) program, led by the National Center for Advancing Translational Sciences, is part of a joint effort on MPS development with the Defense Advanced Research Projects Agency and with regulatory guidance from FDA, is now in its final year of funding. The program has produced many tangible outcomes in tissue chip development in terms of stem cell differentiation, microfluidic engineering, platform development, and single and multi-organ systems—and continues to help facilitate the acceptance and use of tissue chips by the wider community. As the first iteration of the program draws to a close, this Commentary will highlight some of the goals met, and lay out some of the challenges uncovered that will remain to be addressed as the field progresses. The future of the program will also be outlined. Impact statement This work is important to the field as it outlines the progress and challenges faced by the NIH Microphysiological Systems program to date, and the future of the program. This is useful information for the field to be aware of, both for current program stakeholders and future awardees and partners.
Stroke doctors: Who are we? A World Stroke Organization survey
Authors: Meretoja Atte , Acciarresi Monica , Akinyemi Rufus O , Campbell Bruce , Dowlatshahi Dar , English Coralie , Henninger Nils , Poppe Alexandre , Putaala Jukka , Saini Monica , Sato Shoichiro , Wu Bo , Brainin Michael , Norrving Bo , Davis Stephen 
Published: March 2017

Background Specialist training provides skilled workforce for service delivery. Stroke medicine has evolved rapidly in the past years. No prior information exists on background or training of stroke doctors globally. Aims To describe the specialties that represent stroke doctors, their training requirements, and the scientific organizations ensuring continuous medical education. Methods The World Stroke Organization conducted an expert survey between June and November 2014 using e-mailed questionnaires. All Organization for Economic Co-operation and Development countries with >1 million population and other countries with >50 million population were included ( n = 49, total 5.6 billion inhabitants, 85% of global strokes). Two stroke experts from each selected country were surveyed, discrepancies resolved, and further information on identified stroke-specific curricula sought. Results We received responses from 48 (98%) countries. Of ischemic stroke patients, 64% were reportedly treated by neurologists, ranging from 5% in Ireland to 95% in the Netherlands. Per thousand annual strokes there were average six neurologists, ranging from 0.3 in Ethiopia to 33 in Israel. Of intracerebral hemorrhage patients, 29% were reportedly treated by neurosurgeons, ranging from 5% in Sweden to 79% in Japan, with three neurosurgeons per thousand strokes, ranging from 0.1 in Ethiopia to 24 in South Korea. Most countries had a stroke society (86%) while only 10 (21%) had a degree or subspecialty for stroke medicine. Conclusions Stroke doctor numbers, background specialties, and opportunities to specialize in stroke vary across the globe. Most countries have a scientific society to pursue advancement of stroke medicine, but few have stroke curricula.
Efficacy of double-balloon enteroscopy for small-bowel polypectomy: clinical and economic evaluation
Authors: Rahmi Gabriel , Vinet Marie-Amélie , Perrod Guillaume , Saurin Jean-Christophe , Samaha Elia , Ponchon Thierry , Canard Jean-Marc , Edery Joël , Maoulida Hassani , Chatellier Gilles , Durand-Zaleski Isabelle , Cellier Christophe 
Published: March 2017

Background: We evaluated first the feasibility of endoscopic small-bowel polypectomy and second, the economic aspects, by comparing the cost of endoscopic and surgical polyp resection. Methods: A prospective, observational, multicenter study included 494 patients with positive capsule endoscopy (CE) before double-balloon enteroscopy (DBE). We selected only CE with at least one polyp. The retrospective economic evaluation compared patients treated by DBE or surgery for small-bowel polypectomy. Hospital readmission because of repeat polyp resection or complication-related interventions was noted. The 1-year cost was estimated from the viewpoint of the healthcare system and included procedures, hospital admissions and follow up. Results: CE indicated one or more polyps in 62 (12.5%) patients (32 males, 49 ± 5 years), all of whom underwent a successful DBE exploration. The DBE polyp diagnostic yield was 58%. There were no major complications. A total of 26 (42%) patients in the DBE group and 19 (39%) in the control group required hospital readmission. All readmissions in the DBE group were for repeat procedures to remove all polyps, and in the control group, for surgical complications. The total cost of the initial hospitalization (€4014 ± 2239 DBE versus €11,620 ± 7183 surgery, p < 0.0001) and the 1-year total cost (€8438 ± 9227 DBE versus €13,402 ± 7919 surgery, p < 0.0001) were lower in the DBE group. Conclusions: Endoscopic polypectomy was efficient and safe. The total cost at 1 year was less for endoscopy than surgery. DBE should be proposed as the first-line treatment for small-bowel polyp resection.
Reperfusion ventricular arrhythmia bursts identify larger infarct size in spite of optimal epicardial and microvascular reperfusion using cardiac magnetic resonance imaging
Authors: van der Weg Kirian , Kuijt Wichert J , Bekkers Sebastiaan CAM , Tijssen Jan GP , Green Cynthia L , Lemmert Miguel E , Krucoff Mitchell W , Gorgels Anton PM 
Published: March 2017

Aims: Ventricular arrhythmia (VA) bursts following recanalisation in acute ST-elevation myocardial infarction (STEMI) are related to larger infarct size (IS). Inadequate microvascular reperfusion, as determined by microvascular obstruction (MVO) using cardiac magnetic resonance imaging (CMR), is also known to be associated with larger IS. This study aimed to test the hypothesis that VA bursts identify larger infarct size in spite of optimal microvascular reperfusion. Methods: All 65 STEMI patients from the Maastricht ST elevation (MAST) study with brisk epicardial flow (TIMI 3), complete ST recovery post-percutaneous coronary intervention and early CMR were included. Using 24-hour Holter registrations from the time of admission, VA bursts were identified against subject-specific Holter background VA rates using a statistical outlier method. MVO and final IS were determined using delayed enhancement CMR. Results: MVO was present in 37/65 (57%) of patients. IS was significantly smaller in the group without MVO (median 9.4% vs. 20.5%; p < 0.001). IS in the group with MVO did not differ depending on VA burst ( n = 28/37; median 20.8% vs. 19.7%; p = 0.64). However, in the group without MVO, VA burst was associated with significantly larger IS ( n = 17/28; median 10.5% vs. 4.1%; p = 0.037). In multivariable analyses, VA burst as well as anterior infarct location remained independent predictors of larger infarct size. Conclusion: In the presence of suboptimal reperfusion with MVO by CMR, VA burst does not further define MI size. However, with optimal TIMI 3 reperfusion and optimal microvascular perfusion (i.e. no MVO), VA burst is associated with larger IS, indicating that VA burst is a marker of additional cell death.
Maternal fat free mass during pregnancy is associated with birth weight
Authors: Wang Yanxia , Mao Jie , Wang Wenling , Qiou Jie , Yang Lan , Chen Simin 
Published: March 2017

Abstract
Background
The relationship between maternal body compositions and birth weight was not definite. Fat Mass (FM) and Fat Free Mass (FFM) can accurately reflect the maternal body fat compositions and have been considered as better predictors of birth weight. Despite its potential role, no studies have been described the maternal compositions during pregnancy in East Asian women previously. We investigated the correlation between birth weight and Maternal body composition including fat mass (FM) and fat free mass (FFM). To determine whether birth weight is associated with maternal body fat FM and FFM during pregnancy and, if so, which trimester and parameter is more critical in determining birth weight.

Methods
A longitudinal prospective observational study performed, 348, 481 and 321 non-diabetics Han Chinese women with a singleton live birth attending a routine visit in their first, second and third trimesters were recruited. Maternal body composition was measured using segmental multi-frequency bioelectrical impedance analysis. Data of the pre-pregnancy body mass index (BMI), maternal BMI, the gestational weight gain (GWG), and placental and birth weight were collected.

Results
A significant correlation exists between maternal FFM in the process of pregnancy, placental weight, GWG at delivery, and birth weight (P < 0.05). On stepwise multiple linear regression analysis, material’s FFM was the most important factor associated with the birth weight. After adjustment, there was significantly associated with 2.47-fold increase in risk for birth weight more than 4 kg when FFM ≥ 40.76 kg (Upper quartile of participants). The increased maternal age became a protective factor (OR = 0.69) while the increased pre-pregnancy BMI (OR = 1.50) remained predictors to birth weight more than 4 kg.

Conclusions
The change of maternal FFM during pregnancy is independently affected the birth weight.
RETRACTED ARTICLE: First report of the Phe1534Cyskdr mutation in natural populations of Aedes albopictusfrom Brazil
Authors: Aguirre-Obando Oscar Alexander , Martins Ademir Jesus , Navarro-Silva Mário Antônio 
Published: March 2017

AbstractBackgroundKnockdown resistance (kdr), caused by alterations in the voltage-gated sodium channel (NaV), is one of the mechanisms responsible for pyrethroid (PY) resistance. In the Asian tiger mosquito,Aedes albopictus, at least four different mutations were described in the IIIS6 NaVsegment in populations from Asia, North America and Europe. In contrast, inAedes aegyptiat least 12 non-synonymous mutations have been reported at nine different codons, mostly in the IIS6 and IIIS6 NaVsegments. The Phe1534Cyskdrmutation in the IIIS6 NaVsegment is the most prevalent in populations ofAe. aegyptiworldwide, also found inAe. albopictusfrom Singapore. Herein, we investigated the DNA diversity corresponding to the IIS6 and IIIS6 NaVsegments in natural populations ofAe. albopictusfrom Brazil.MethodsDNA from eight BrazilianAe. albopictusnatural populations were individually extracted and pooled by states of origin, amplified, cloned and sequenced for the corresponding IIS6 and IIIS6 NaVsegments. Additionally, samples from each location were individually genotyped by an allelic specific PCR (AS-PCR) approach to obtain the genotypic and allelic frequencies for the 1534 NaVsite.ResultsNo non-synonymous substitutions were observed in the IIS6 sequences. However, the Phe1534Cyskdrmutation was evidenced in theAe. albopictusNaVIIIS6 segment sequences from Paraná (PR) and Rondônia (RO) states, but not from Mato Grosso (MT) state. The 1534Cyskdrallele varied from 3% (Marilena/PR and Porto Velho/RO) to 10% (Foz do Iguaçu/PR). To our knowledge, this paper reports the first occurrence and provides distribution data of a possiblekdrmutation inAe. albopictusin South America.ConclusionThe emergence of a likelykdrmutation inAe. albopitusnatural populations is a signal of alert for vector control measures since PY are the most popular insecticides adopted by residents. Additionally, once thekdrallele is present, its frequency tends to increase faster under exposition to those compounds. Although the Asian tiger mosquito is not incriminated as an important vector of dengue, chikungunya and Zika viruses in South America, its importance in this regard has been extensively discussed sinceAe. albopictusis rapidly spreading and can also migrate between sylvatic and urban environments. Therefore, insecticide resistance monitoring initiatives should also be extended toAe. albopictusin Brazil in order to maintain chemical compounds as an efficient vector control tool when needed.
Patient-Reported Outcomes 1 Year After Immediate Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study
Authors: Pusic Andrea L. , Matros Evan , Fine Neil , Buchel Edward , Gordillo Gayle M. , Hamill Jennifer B. , Kim Hyungjin M. , Qi Ji , Albornoz Claudia , Klassen Anne F. , Wilkins Edwin G. 
Published: March 2017

Purpose The goals of immediate postmastectomy breast reconstruction are to minimize deformity and optimize quality of life as perceived by patients. We prospectively evaluated patient-reported outcomes (PROs) in women undergoing immediate implant-based or autologous reconstruction. Methods Women undergoing immediate postmastectomy reconstruction for invasive cancer and/or carcinoma in situ were enrolled at 11 sites. Women underwent implant-based or autologous tissue reconstruction. Patients completed the BREAST-Q, a condition-specific PRO measure for breast surgery patients, and Patient-Reported Outcomes Measurement Information System–29, a generic PRO measure, before and 1 year after surgery. Mean changes in PRO scores were summarized. Mixed-effects regression models were used to compare PRO scores across procedure types. Results In total, 1,632 patients (n = 1,139 implant, n = 493 autologous) were included; 1,183 (72.5%) responded to 1-year questionnaires. After analysis was controlled for baseline values, patients who underwent autologous reconstruction had greater satisfaction with their breasts than those who underwent implant-based reconstruction (difference, 6.3; P < .001), greater sexual well-being (difference, 4.5; P = .003), and greater psychosocial well-being (difference, 3.7; P = .02) at 1 year. Patients in the autologous reconstruction group had improved satisfaction with breasts (difference, 8.0; P = .002) and psychosocial well-being (difference, 4.6; P = .047) compared with preoperative baseline. Physical well-being of the chest was not fully restored in either the implant group (difference, −3.8; P = .001) or autologous group (−2.2; P = .04), nor was physical well-being of the abdomen in patients who underwent autologous reconstruction (−13.4; P < .001). Anxiety and depression were mitigated at 1 year in both groups. Compared with their baseline reports, patients who underwent implant reconstruction had decreased fatigue (difference, −1.4; P = .035), whereas patients who underwent autologous reconstruction had increased pain interference (difference, 2.0; P = .006). Conclusion At 1 year after mastectomy, patients who underwent autologous reconstruction were more satisfied with their breasts and had greater psychosocial and sexual well-being than those who underwent implant reconstruction. Although satisfaction with breasts was equal to or greater than baseline levels, physical well-being was not fully restored. This information can help patients better understand expected outcomes and may guide innovations to improve outcomes.
Information-Based Allocation Strategy for GRID-Based Transshipment Automated Container Terminal
Authors: Zhou Chenhao , Chew Ek Peng , Lee Loo Hay 
Published: March 2017

In this paper, we introduce a storage allocation strategy for a transshipment container hub using a new automated container terminal called the hybrid GRID system. This study provides a novel approach of developing an efficient storage allocation strategy for new terminal concepts so that the complex formulations can be approximated by simple functions that can be quickly computed. Specifically, the storage allocation strategy is derived from an optimal allocation decision learned from a Mixed Integer Programming (MIP) model. Some input parameters of the MIP model are collected from a simulation model. An index measuring the storage location convenience is proposed and we regress this index with important variables to build an empirical model that provides recommendations on where to allocate containers to storage locations. The advantage of using the empirical approach is that it allows for fast computation which is expected in the dynamic and uncertain port environment. Numerical results show that four variables can significantly affect the performance of the allocation decision. This strategy is shown to be robust for different scenarios in terms of terminal configuration and container workload. In addition, the new strategy performs better than the commonly used strategies found in warehousing literatures, and the solution is close to the optimal allocation decision. The online appendix is available at https://doi.org/10.1287/trsc.2017.0736 .