bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning for automated drivetrain fault detection
Authors: Bach‐Andersen Martin , Rømer‐Odgaard Bo , Winther Ole 
Published: October 2017

AbstractA novel data‐driven deep‐learning system for large‐scale wind turbine drivetrain monitoring applications is presented. It uses convolutional neural network processing on complex vibration signal inputs. The system is demonstrated to learn successfully from the actions of human diagnostic experts and provide early and robust fault detection on both rotor bearing, planetary and helical stage gear box bearings from analysis of multisensor vibration patterns using only a high‐level feature selection. On the basis of data from 251 actual wind turbine bearing failures, we are able to accurately quantify the fleet‐wide diagnostic model performance. The analysis also explores the time dependence of the diagnostic performance, providing a detailed view of the timeliness and accuracy of the diagnostic outputs across the different architectures. Deep architectures are shown to outperform the human analyst as well as shallow‐learning architectures, and the results demonstrate that when applied in a large‐scale monitoring system, machine intelligence is now able to handle some of the most challenging diagnostic tasks related to wind turbines.
Russian soft power in Ukraine: A structural perspective
Authors: Cheskin Ammon 
Published: October 2017

In this article, I adopt a structural approach to Russian soft power, switching focus from the supposed agent of power (Russia), towards the subjects of power (Ukrainians). I outline the applicability of this approach to empirical studies into soft power, demonstrating how soft power can be examined from bottom-up, discursively-focused perspectives.
The empirical analysis then traces how Ukrainians (do not) link their self-identities to discursive understanding of “Russia”. Reviewing recent insights into the relationship between soft power and affect, I argue that Ukrainians’ cultural, historical and linguistic ties with Russia often lack necessary emotional force to generate meaningful soft power.
Making and Breaking Microliths: A Middle Mesolithic Site at Asfordby, Leicestershire
Authors: Cooper Lynden P. , Jarvis Wayne , Bayliss Alex , Beamish Matthew G. , Bronk Ramsey Christopher , Browning Jennifer , Brettell Rhea , Cook Gordon , Evans Adrian , Heron Carl , Macphail Richard 
Published: October 2017

Archaeological fieldwork preceding housing development revealed a Mesolithic site in a primary context. A central hearth was evident from a cluster of calcined flint and bone, the latter producing a modelled date for the start of occupation at 8220–7840 calbcand ending at 7960–7530 calbc(95% probability). The principal activity was the knapping of bladelets, the blanks for microlith production. Impact-damaged microliths indicated the re-tooling of hunting weaponry, while microwear analysis of other tools demonstrated hide working and butchery activity at the site. The lithics can be classified as a Honey Hill assemblage type on the basis of distinctive leaf-shaped microlithic points with inverse basal retouch.Such assemblages have a known concentration in central England and are thought to be temporally intermediate between the conventional British Early and Late Mesolithic periods. The lithic assemblage is compared to other Honey Hill type and related Horsham type assemblages from south-eastern England. Both assemblage types are termed Middle Mesolithic and may be seen as part of wider developments in the late Preboreal and Boreal periods of north-west Europe. Rapid climatic warming at this time saw the northward expansion of deciduous woodland into north-west Europe. Emerging new ecosystems presented changes in resource patterns and the Middle Mesolithic lithic typo-technological developments reflect novel foraging strategies as adaptations to the new opportunities of Boreal forest conditions. While Honey Hill-type assemblages are seen as part of such wider processes their distinctive typological signature attests to autochthonous, regional developments of human groups infilling the landscape. Such cultural insularity may reflect changing social boundaries with reduction in mobility range and physical isolation caused by rising sea level and the creation of the British archipelago.
Taking Newton on tour: the scientific travels of Martin Folkes, 1733–1735
Authors: ROOS ANNA MARIE 
Published: October 2017

AbstractMartin Folkes (1690–1754) was Newton's protégé, an English antiquary, mathematician, numismatist and astronomer who would in the latter part of his career become simultaneously president of the Royal Society and of the Society of Antiquaries. Folkes took a Grand Tour from March 1733 to September 1735, recording the Italian leg of his journey from Padua to Rome in his journal. This paper examines Folkes's travel diary to analyse his Freemasonry, his intellectual development as a Newtonian and his scientific peregrination. It shows how, in this latter area, how he used metrology to understand not only the aesthetics but also the engineering principles of antique buildings and artefacts, as well as their context and place in the Italian landscape. Using Folkes's diary, his account book of his journey in the Norwich archives, and his correspondence with other natural philosophers such as Francesco Algarotti (1712–1764), Anders Celsius (1701–1744) and Abbé Antonio Schinella Conti (1667–1749), this paper will also demonstrate to what extent Folkes's journey established his reputation as an international broker of Newtonianism, as well as the overall primacy of English scientific instrumentation to Italian virtuosi.
Comparative analysis of effects of dietary arachidonic acid and EPA on growth, tissue fatty acid composition, antioxidant response and lipid metabolism in juvenile grass carp,Ctenopharyngodon idellus
Authors: Tian Jing-jing , Lei Cai-xia , Ji Hong , Kaneko Gen , Zhou Ji-shu , Yu Hai-bo , Li Yang , Yu Er-meng , Xie Jun 
Published: October 2017

AbstractFour isonitrogenous and isoenergetic purified diets containing free arachidonic acid (ARA) or EPA (control group), 0·30 % ARA, 0·30 % EPA and 0·30 % ARA+EPA (equivalent) were designed to feed juvenile grass carp (10·21 (sd0·10) g) for 10 weeks. Only the EPA group presented better growth performance compared with the control group (P<0·05). Dietary ARA and EPA were incorporated into polar lipids more than non-polar lipids in hepatopancreas but not intraperitoneal fat (IPF) tissue. Fish fed ARA and EPA showed an increase of serum superoxide dismutase and catalase activities, and decrease of glutathione peroxidase activity and malondialdehyde contents (P<0·05). The hepatopancreatic TAG levels decreased both in ARA and EPA groups (P<0·05), accompanied by the decrease of lipoprotein lipase (LPL) activity in the ARA group (P<0·05). Fatty acid synthase (FAS), diacylglycerolO-acyltransferase andapoEgene expression in the hepatopancreas decreased in fish fed ARA and EPA, but only the ARA group exhibited increased mRNA level of adipose TAG lipase (ATGL) (P<0·05). Decreased IPF index and adipocyte sizes were found in the ARA group (P<0·05). Meanwhile, the ARA group showed decreased expression levels of adipogenic genes CCAAT enhancer-binding proteinα,LPLandFAS, and increased levels of the lipid catabolic genesPPARα,ATGL, hormone-sensitive lipase and carnitine palmitoyltransferase 1 (CPT-1) in IPF, whereas the EPA group only increasedPPARαandCPT-1mRNA expression and showed less levels than the ARA group. Overall, dietary EPA is beneficial to the growth performance, whereas ARA is more potent in inducing lipolysis and inhibiting adipogenesis, especially in IPF. Meanwhile, dietary ARA and EPA showed the similar preference in esterification and the improvement in antioxidant response.
Toenail selenium levels and prevalence of dyslipidaemia among Korean adults
Authors: Jang Jiyoung , Morris J. Steven , Park Kyong 
Published: October 2017

AbstractMultiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations. We analysed baseline data from a cohort in the Yeungnam area, including 232 men and 269 women. Information on demographic, dietary and lifestyle characteristics was obtained through a self-reported questionnaire. Se levels in toenail specimens were measured using neutron activation analysis. Fasting blood lipid levels were measured during medical examinations. After adjusting for multiple confounding variables, we observed no association between toenail Se levels and dyslipidaemia or individual lipid profiles. However, the association was modified by dietary supplement use. Among the supplement users, higher toenail Se levels were associated with a higher prevalence of lipid dysregulation, whereas non-users exhibited a lower prevalence of lipid dysregulation. Associations between toenail Se levels, lipid levels and dyslipidaemia may be influenced by taking dietary supplements. Future large-scale, prospective cohort studies should be conducted to further evaluate the association between Se levels in the body and metabolic health effects in light of increasing rates of dietary supplement use.
The impact of sociodemographic and health-service factors on breast-feeding in sub-Saharan African countries with high diarrhoea mortality
Authors: Ogbo Felix A , Eastwood John , Page Andrew , Efe-Aluta Oniovo , Anago-Amanze Chukwudi , Kadiri Eshioramhe A , Ifegwu Ifegwu K , Woolfenden Sue , Agho Kingsley E 
Published: October 2017

AbstractObjectiveThe current study aimed to examine the impact of sociodemographic and health-service factors on breast-feeding in sub-Saharan African (SSA) countries with high diarrhoea mortality.DesignThe study used the most recent and pooled Demographic and Health Survey data sets collected in nine SSA countries with high diarrhoea mortality. Multivariate logistic regression models that adjusted for cluster and sampling weights were used to investigate the association between sociodemographic and health-service factors and breast-feeding in SSA countries.SettingSub-Saharan Africa with high diarrhoea mortality.SubjectsChildren (n 50 975) under 24 months old (Burkina Faso (2010, N 5710); Demographic Republic of Congo (2013, N 6797); Ethiopia (2013, N 4193); Kenya (2014, N 7024); Mali (2013, N 3802); Niger (2013, N 4930); Nigeria (2013, N 11 712); Tanzania (2015, N 3894); and Uganda (2010, N 2913)).ResultsOverall prevalence of exclusive breast-feeding (EBF) and early initiation of breast-feeding (EIBF) was 35 and 44 %, respectively. Uganda, Ethiopia and Tanzania had higher EBF prevalence compared with Nigeria and Niger. Prevalence of EIBF was highest in Mali and lowest in Kenya. Higher educational attainment and frequent health-service visits of mothers (i.e. antenatal care, postnatal care and delivery at a health facility) were associated with EBF and EIBF.ConclusionsBreast-feeding practices in SSA countries with high diarrhoea mortality varied across geographical regions. To improve breast-feeding behaviours among mothers in SSA countries with high diarrhoea mortality, breast-feeding initiatives and policies should be context-specific, measurable and culturally appropriate, and should focus on all women, particularly mothers from low socio-economic groups with limited health-service access.
Online Publication of Court Decisions in Europe
Authors: van Opijnen Marc , Peruginelli Ginevra , Kefali Eleni , Palmirani Monica 
Published: October 2017

AbstractAlthough nowadays most courts publish decisions on the internet, substantial differences exist between European countries regarding such publication. These differences not only pertain to the extent with which judgments are published and anonymised, but also to their metadata, searchability and reusability. This article, written by Marc van Opijnen, Ginevra Peruginelli, Eleni Kefali and Monica Palmirani, contains a synthesis of a comprehensive comparative study on the publication of court decisions within all Member States of the European Union. Specific attention is paid on the legal and policy frameworks governing case law publication, actual practices, data protection issues, Open Data policies as well as the state of play regarding the implementation of the European Case Law Identifier.
Use of Mobile Technologies by Law Students in the Law Library: an Exploratory Study
Authors: Abbas Zaki , MacFarlane Andrew , Robinson Lyn 
Published: October 2017

AbstractThis paper outlines the first part of a wider, two-part study on the information behaviour of law students. The authors are Zaki Abbas, Andrew MacFarlane and Lyn Robinson. The background and motivation for the study have been described in a previous publication1 which reports the results of interviews with three academic law librarians. Our initial work found that although mobile technologies offered benefits to law students seeking information for their academic studies, there was concern from law librarians that the use of electronic resources via both non-mobile and mobile interfaces resulted in a loss of skills required for information retrieval due to the increasing capabilities of electronic resources’ search interfaces. To gain more insight into how law students were using mobile information resources, and to further understand the advantages and disadvantages of such resources, we extended our study to a wider cohort. This second phase, of our first part study, was conducted over two years (2013–2015). During this time, we carried out interviews with thirteen law librarians and fielded both quantitative and qualitative questionnaires to 36 law students. We also conducted a greater review of literature and examined several existing information-seeking models. We used the results of the research from this phase of study, together with the knowledge from the literature to propose a novel information-seeking behaviour (ISB) model for law students. These findings are reported within this paper. The second part of this research will look at expanding our research cohort to cover a wider audience throughout the UK and use a focus group to validate our proposed model. This will be reported in a following paper.
Reflective Learning and After Action Reviews
Authors: Russell Hélène 
Published: October 2017

AbstractFormalised reflective learning systems are one of the most effective and yet underutilised methods of learning. This article, written by Hélène Russell, aims to give you the tools to use after action reviews (AAR) for your information management (IM) and knowledge management (KM) projects so you can learn from your experiences for greater success in the future and also to lead AAR meetings for other professionals within your organisation, to help increase their experiential learning.
Re-evaluating Legal Citation in a Digital Landscape
Authors: Castan Melissa , Galloway Kate 
Published: October 2017

AbstractIncreasing access to digital works and the proliferation of digital genres has changed the way in which we conceive of information, and particularly legal information, including how it is represented within legal citation practice. This article, written by Melissa Castan and Kate Galloway, contributes to the discourse around legal citation in two ways. It first provides a theoretical justification for citation practice as an element of legal information management crucial to effective scholarship, including knowledge creation and dissemination. Secondly, and based on this theoretical foundation, it identifies the challenges facing existing legal citation practice in the face of new media, new representations of legal scholarship, and new objectives for citation practice. Finally, in this article we distil foundation principles for citation to integrate these diverse elements. To illustrate the application of these principles, the article closes with suggested citation practices designed to enhance the existing framework in this digital landscape.
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage
Authors: Boia Raquel , Elvas Filipe , Madeira Maria H , Aires Inês D , Rodrigues-Neves Ana C , Tralhão Pedro , Szabó Eszter C , Baqi Younis , Müller Christa E , Tomé Ângelo R , Cunha Rodrigo A , Ambrósio António F , Santiago Ana R 
Published: October 2017

AbstractTransient retinal ischemia is a major complication of retinal degenerative diseases and contributes to visual impairment and blindness. Evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia–reperfusion (I–R). The available therapeutic strategies for retinal degenerative diseases have limited potential, but the blockade of adenosine A2A receptor (A2AR) emerges as candidate strategy. Therefore, we evaluated the therapeutic potential of a selective A2AR antagonist (KW6002) against the damage elicited by I–R. The administration of KW6002 after I–R injury reduced microglia reactivity and inflammatory response and afforded protection to the retina. Moreover, we tested the ability of caffeine, an adenosine receptor antagonist, in mediating protection to the retina in the I–R injury model. We demonstrated that caffeine administration dually regulated microglia reactivity and cell death in the transient retinal ischemic model, depending on the reperfusion time. At 24 h of reperfusion, caffeine increased microglial reactivity, inflammatory response and cell death elicited by I–R. However, at 7 days of reperfusion, caffeine administration decreased microglia reactivity and reduced the levels of proinflammatory cytokines and cell death. Together, these results provide a novel evidence for the use of adenosine A2AR antagonists as potential therapy for retinal ischemic diseases and demonstrate the effect of caffeine on the regulation of microglia-mediated neuroinflammation in the transient ischemic model.
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells
Authors: Hsin Min-Chieh , Hsieh Yi-Hsien , Wang Po-Hui , Ko Jiunn-Liang , Hsin I-Lun , Yang Shun-Fa 
Published: October 2017

AbstractHispolon, a phenolic compound isolated from Phellinus igniarius, induces apoptosis and anti-tumor effects in cancers. However, the molecular mechanism involved in hispolon-mediated tumor-suppressing activities observed in cervical cancer is poorly characterized. Here, we demonstrated that treatment with hispolon inhibited cell metastasis in two cervical cancer cell lines. In addition, the downregulation of the lysosomal protease Cathepsin S (CTSS) was critical for hispolon-mediated suppression of tumor cell metastasis in both in vitro and in vivo models. Moreover, hispolon induced autophagy, which increased LC3 conversion and acidic vesicular organelle formation. Mechanistically, hispolon inhibited the cell motility of cervical cells through the extracellular signal-regulated kinase (ERK) pathway, and blocking of the ERK pathway reversed autophagy-mediated cell motility and CTSS inhibition. Our results indicate that autophagy is essential for decreasing CTSS activity to inhibit tumor metastasis by hispolon treatment in cervical cancer; this finding provides a new perspective on molecular regulation.
Involvement of miR-451 in resistance to paclitaxel by regulating YWHAZ in breast cancer
Authors: Wang Wenrui , Zhang Lingyu , Wang Yangyang , Ding Yongxing , Chen Tiantian , Wang Yueyue , Wang Haifeng , Li Yu , Duan Kecai , Chen Sulian , Yang Qingling , Chen Changjie 
Published: October 2017

AbstractMicroRNAs (miRNAs) have been identified as major post-transcriptional regulators of the initiation and progression of human cancers, including breast cancer. However, the detail role of miR-451 has not been fully elucidated in breast cancer. In this study, we aimed to investigate the biological role and molecular mechanisms of miR-451 in drug resistance in breast cancer cell lines and in xenograft model. We show that miR-451 is decreased in human breast cancer specimens and in paclitaxel-resistant (PR) cells. Ectopic expression of miR-451 could inhibit the cell migration and invasion, promoted apoptosis, induced cell-cycle arrest Furthermore, tyrosine3-monooxygenase/tryptophan5-monooxygenase activation protein zeta (YWHAZ) was identified as a direct target of miR-451. Remarkably, the expression of YWHAZ is inversely correlated with the level of miR-451 in human breast cancer samples. Co-treatment with miR-451 mimics and YWHAZ-siRNA significantly enhanced YWHAZ knockdown in both SKBR3/PR and MCF-7/PR cells Moreover, miR-451 markedly inhibited expression of β-catenin via YWHAZ and subsequently inhibited downstream gene cyclin D1, c-Myc expression. The results of xenograft model in vivo showed that intratumor injection of miR-451 agomir induced a tumor-suppressive effect in SKBR3/PR drug-resistant xenograft model. Taken together, our findings suggested that miR-451 might be considered as important and potential target in paclitaxel-resistant breast cancer treatment.
Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways
Authors: Kumari Puja , Saha Irene , Narayanan Athira , Narayanan Sathish , Takaoka Akinori , Kumar Nachimuthu Senthil , Tailor Prafullakumar , Kumar Himanshu 
Published: October 2017

AbstractCancer is a multifactorial disease and virus-mediated carcinogenesis is one of the crucial factors, which is poorly understood. Human cytomegalovirus (HCMV) is a herpesvirus and its components have been evidenced to be associated with cancer of different tissue origin. However, its role in cancer remains unknown. Here, we identified a conserved herpesviral tegument protein known as pUL48 of HCMV, encoding deubiquitinase enzyme, as having a key role in carcinogenesis. We show using deubiquitinase sufficient- and deficient-HCMV that HCMV deubiquitinase is a key in inducing enhanced cellular metabolic activity through upregulation of several anti-apoptotic genes and downregulation of several pro-apoptotic genes expression. Furthermore, HCMV deubiquitinase acquires pro-tumor functions by inhibiting PRR-mediated type I interferon via deubiquitination of TRAF6, TRAF3, IRAK1, IRF7 and STING. Taken together, our results suggest that HCMV infection may promote oncogenesis by inhibiting innate immunity of the host.