bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic Staff Turnover Intention in Madda Walabu University, Bale Zone, South-east Ethiopia
Authors: Ibrahim Ibrahim Yimer , Kassa Rahel Nega , Tasisa Gemechu Ganfure 
Published: May 2017

AbstractIntroduction: Employee retention is one of the challenges facing several organizations in both the developed and developing countries of the world. Higher education institutions serve as storehouses of knowledge for nurturing the manpower needs of the nation. Higher education institutions are therefore more dependent on the intellectual and creative abilities and commitment of the academic staff than most other organizations. This therefore makes it critically important to retain this cadre of staff. This research was carried out to determine the prevalence of academic staff turnover intention and the factors contributing for it among Madda Walabu University academic staff.Methods: An institution based cross sectional study design was employed. Two hundred and seventeen academic staff were selected randomly and interviewed using a structured self-administered questionnaire. An in-depth interview was carried out on six academic staff. Binary and multiple logistic regression analysis was used using SPSS version 16. To have a more accurate result, triangulation of quantitative findings and an in-depth interview was used. Results: A total of 217 academicians responded to the questionnaire. One hundred sixty four, (75.6%) respondents intended to leave Madda Walabu University and 24.4% of academic staff intended to retain their position or post. A bad work environment (lack of facilities like offices, chairs, internet and toilets) was the most frequently cited reason for leaving (71.3%) followed by 63.4% due to poor management and leadership and 63.4% due to inadequate salary. Academic staff who had worked five or more years in Madda Walabu University were 4.5 times more likely to leave their institution [AOR = 4.5, 95% CI: 1.37, 14.9]. Conclusion: The prevalence of academic staff intending to leave was found to be very high and as a result, Madda Walabu University will be in an alarming state of staff turnover. Before this happens, there should be staff retention mechanisms in place to improve the work environment, management and leadership and remuneration methods to retain senior and skilled academicians.
Transcriptome sequencing and SNP detection in Phoebe chekiangensis
Authors: He Bing , Li Yingang , Ni Zhouxian , Xu Li-an 
Published: May 2017

Background
Phoebe chekiangensis is a rare tree species that is only distributed in south-eastern China. Although this species is famous for its excellent wood properties, it has not been extensively studied at the molecular level.

Results
Here, the transcriptome of P. chekiangensis was sequenced using next-generation sequencing technology, and 75,647 transcripts with 48,011 unigenes were assembled and annotated. In addition, 162,938 putative single nucleotide polymorphisms (SNPs) were predicted and 25 were further validated using the Sanger method.

Conclusion
The currently available SNP prediction software packages showed low levels of correspondence when compared. The transcriptome and SNPs will contribute to the exploration of P. chekiangensis genetic resources and the understanding of its molecular mechanisms.
Sound velocity of liquid Fe‐Ni‐S at high pressure
Authors: Kawaguchi Saori I. , Nakajima Yoichi , Hirose Kei , Komabayashi Tetsuya , Ozawa Haruka , Tateno Shigehiko , Kuwayama Yasuhiro , Tsutsui Satoshi , Baron Alfred Q. R. 
Published: May 2017

AbstractThe sound velocity of liquid Fe47Ni28S25 and Fe63Ni12S25 was measured up to 52 GPa/2480 K in externally resistance‐heated and laser‐heated diamond‐anvil cells using high‐resolution inelastic X‐ray scattering. From these experimental data, we obtained the elastic parameters of liquid Fe47Ni28S25, KS0 = 96.1 ± 2.7 GPa and KS0′ = 4.00 ± 0.13, where KS0 and KS0′ are the adiabatic bulk modulus and its pressure derivative at 1 bar, when the density is fixed at ρ0 = 5.62 ± 0.09 g/cm3 for 1 bar and 2000 K. With these parameters, the sound velocity and density of liquid Fe47Ni28S25 were calculated to be 8.41 ± 0.17 km/s and 8.93 ± 0.19 to 9.10 ± 0.18 g/cm3, respectively, at the core mantle boundary conditions of 135 GPa and 3600–4300 K. These values are 9.4% higher and 17–18% lower than those of pure Fe, respectively. Extrapolation of measurements and comparison with seismological models suggest the presence of 5.8–7.5 wt % sulfur in the Earth's outer core if it is the only light element.
Cover Image, Volume 11, Issue 3
Authors: Zhao Xuebing , Li Siming , Wu Ruchun , Liu Dehua 
Published: May 2017

The cover image, by Xuebing Zhao et al., is based on the Review Organosolv fractionating pre‐treatment of lignocellulosic biomass for efficient enzymatic saccharification: chemistry, kinetics, and substrate structures, DOI: 10.1002/bbb.1768.
image
Reducing Macro‐ and Microheterogeneity of N‐Glycans Enables the Crystal Structure of the Lectin and EGF‐Like Domains of Human L‐Selectin To Be Solved at 1.9 Å Resolution
Authors: Wedepohl Stefanie , Dernedde Jens , Vahedi‐Faridi Ardeschir , Tauber Rudolf , Saenger Wolfram , Bulut Haydar 
Published: May 2017

AbstractL‐Selectin, a cell‐adhesion receptor on the surface of most leukocytes, contains seven N‐glycosylation sites. In order to obtain the crystal structure of human L‐selectin, we expressed a shortened version of L‐selectin comprising the C‐type lectin and EGF‐like domains (termed LE) and systematically analysed mutations of the three glycosylation sites (Asn22, Asn66 and Asn139) in order to reduce macroheterogeneity. After we further removed microheterogeneity, we obtained crystals that diffracted X‐rays up to 1.9 Å from a variant (LE010) with exchanges N22Q and N139Q and one GlcNAc2Man5 N‐glycan chain attached to Asn66. Crystal‐structure analysis showed that the terminal mannose of GlcNAc2Man5 of one LE010 molecule was coordinated to Ca2+ in the binding site of a symmetry‐related LE010. The orientation of the lectin and EGF‐like domain was similar to the described “bent” conformation of E‐ and P‐selectins. The Ca2+‐binding site reflects the binding mode seen in E‐ and P‐selectin structures co‐crystallised with ligands.
FSCN1 is upregulated by SNAI2 and promotes epithelial to mesenchymal transition in head and neck squamous cell carcinoma
Authors: Wang Lei , Jia YaoPeng , Jiang ZengYu , Gao Wei , Wang BinQuan 
Published: May 2017

AbstractIn this study, we investigated whether there is any association between the expression of FSCN1 and SNAI2 and the possible underlying mechanisms in head and neck squamous cell carcinoma (HNSC). In addition, we also investigated whether FSCN1 modulates epithelial‐to‐mesenchymal transition (EMT) in HNSC cells. Microarray data of dysregulated genes in HNSC were searched in GEO datasets. The association between FSCN1 expression and the 5‐year/10‐year overall survival (OS), as well as the correlation between the expression of FSCN1 and SOX2, MYBL2, SNAI2, STAT1, and SOX4, was analyzed based on data in TCGA HNSC cohort (TCGA‐HNSC). The binding site of SNAI2 in FSCN1 promoter was verified using luciferase reporter assay. SCC9 and SCC15 cells were transfected with pCMV‐SNAI2 or pCMV‐FSCN1 expression vector or the empty control. Alteration of E‐cadherin, Claudin 1, Vimentin, and N‐cadherin was then quantified. Our results showed that FSCN1 is significantly upregulated in HNSC tissues compared with the normal control tissues. High FSCN1 expression is associated with worse 5‐year and 10‐year OS among the HNSC patients. Bioinformatic prediction showed a highly possible SNAI2 binding site in FSCN1 promoter and following luciferase reporter assay verified this site. SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E‐cadherin and Claudin 1, but increased the expression of Vimentin and N‐cadherin in SCC9 and SCC‐15 cells. Therefore, we infer that FSCN1 is a downstream effector of SNAI2 in promoting EMT in HNSC cells.
Dollars and stents: A brave new world
Authors: Krishnan Sandeep K. , Dean Larry S. 
Published: May 2017

Key Points

Reimbursement in the healthcare system is shifting from pure volume to a mixed volume/value‐based metric.
Using complex statistical modeling to adjust for unknowns, the study provides real world data that the use of Co‐Cr EES is more cost effective than BMS assuming that clinicians select clopidogrel for P2Y12 inhibition.
More cost‐effectiveness analyses should be conducted to guide the use of ever costlier novel medical devices and drugs.
Low Gradient, “Dismal” Outcome TAVR: Should We?
Authors: Butman Samuel M. 
Published: May 2017

Key Points

Low gradient (<40 mm) aortic valve stenosis (AVA < 1.0 cm2) outcomes with TAVR are worse than when gradients are > 40 mm Hg.
Concomitant coronary disease, older age, presence of diabetes, and lower ejection fraction in patients with low gradient aortic valve stenosis account for the poorer outcome after TAVR.
Historically, similar results have been seen with surgical AVR.
How Can Methanol Dehydrogenase from Methylacidiphilum fumariolicum Work with the Alien CeIII Ion in the Active Center? A Theoretical Study
Authors: Prejanò Mario , Marino Tiziana , Russo Nino 
Published: May 2017

AbstractLanthanides are an example of nonbiogenic metal species and have been widely used in crystallographic and spectroscopic studies to probe Mg2+/Ca2+ binding sites in metalloproteins by replacing the native cofactor. Recently, a methanol dehydrogenase (MDH) enzyme containing cerium ion in the active site has been isolated from Methylacidiphilum fumariolicum bacterium. With the aim to highlight as metal ion substitution can be reflected in catalytic mechanism, a comparative DFT study between Ca‐ and Ce‐MDH has been undertaken. The obtained potential energy surfaces (PES), for two considered reaction mechanisms (named A and B), indicate mechanism A (addition‐elimination and protonation processes) as the favored for both the enzymes and show as the barrier for the rate‐determining step of Ce‐MDH requires 19.4 kcal mol−1.
Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes
Authors: Xiao Zeyun , Bonnard Thomas , Shakouri‐Motlagh Aida , Wylie Ross A. L. , Collins Joe , White Jonathan , Heath Daniel E. , Hagemeyer Christoph E. , Connal Luke A. 
Published: May 2017

AbstractHydrogen sulfide (H2S) has been identified as an important cell‐signaling mediator and has a number of biological functions, such as vascular smooth muscle relaxation, neurotransmission, and regulation of inflammation. A facile and versatile approach for H2S production initiated by light irradiation and controlled by reaction with an amine or an amino acid was developed. The donor was synthesized in a one‐pot reaction, and simple crystallization led to a yield of approximately 90 %. The synthetic strategy is scalable and versatile, and the H2S donors can be expressed ina number of different molecular and macromolecular forms, including crystalline small‐molecule compounds, water‐soluble polymers, polystyrene films, and hydrogels. The H2S donors based on polystyrene film and hydrogel were used as cell‐culture scaffolds. The H2S donor based on water‐soluble polymer was applied in photocontrolled inhibition of P‐selectin expression on human platelets and subsequent regulation of platelet aggregation. This study provides the simplest controllable H2S source to study its biological functions. The developed materials are also new therapeutic platforms to deliver H2S, as there is no accumulation of toxic byproducts, and the donor materials from polystyrene films and hydrogels can be readily removed after releasing H2S.
Barrington's nucleus: Neuroanatomic landscape of the mouse “pontine micturition center”
Authors: Verstegen Anne M. J. , Vanderhorst Veronique , Gray Paul A. , Zeidel Mark L. , Geerling Joel C. 
Published: May 2017

AbstractBarrington's nucleus (Bar) is thought to contain neurons that trigger voiding and thereby function as the “pontine micturition center.” Lacking detailed information on this region in mice, we examined gene and protein markers to characterize Bar and the neurons surrounding it. Like rats and cats, mice have an ovoid core of medium‐sized Bar neurons located medial to the locus coeruleus (LC). Bar neurons express a GFP reporter for Vglut2, develop from a Math1/Atoh1 lineage, and exhibit immunoreactivity for NeuN. Many neurons in and around this core cluster express a reporter for corticotrophin‐releasing hormone (BarCRH). Axons from BarCRH neurons project to the lumbosacral spinal cord and ramify extensively in two regions: the dorsal gray commissural and intermediolateral nuclei. BarCRH neurons have unexpectedly long dendrites, which may receive synaptic input from the cerebral cortex and other brain regions beyond the core afferents identified previously. Finally, at least five populations of neurons surround Bar: rostral‐dorsomedial cholinergic neurons in the laterodorsal tegmental nucleus; lateral noradrenergic neurons in the LC; medial GABAergic neurons in the pontine central gray; ventromedial, small GABAergic neurons that express FoxP2; and dorsolateral glutamatergic neurons that express FoxP2 in the pLC and form a wedge dividing Bar from the dorsal LC. We discuss the implications of this new information for interpreting existing data and future experiments targeting BarCRH neurons and their synaptic afferents to study micturition and other pelvic functions.
Insecure attachment and maladaptive schema in disordered eating: The mediating role of rejection sensitivity
Authors: De Paoli Tara , Fuller‐Tyszkiewicz Matthew , Krug Isabel 
Published: May 2017

AimThe current study aimed to assess insecure attachment and the disconnection and rejection domain of maladaptive schema in the context of disordered eating. Rejection sensitivity (RS) was proposed as a mediator between maladaptive schema and disordered eating.MethodThe sample consisted of 108 female participants with a lifetime eating disorder diagnosis and 508 female control participants. Participants were asked to complete a number of self‐report measures related to insecure attachment (anxious and avoidant), maladaptive schema (emotional deprivation, abandonment, mistrust, social isolation, and defectiveness), RS (interpersonal and appearance‐based), and disordered eating.ResultsPath analysis indicated that anxious attachment was associated with disordered eating through multiple pathways involving emotional deprivation, abandonment, interpersonal RS, and appearance‐based RS. Avoidant attachment was not related to disordered eating behaviours.ConclusionThe results indicate that both interpersonal and appearance‐based RS are important mediators for the relationships between insecure attachment, maladaptive schema, and disordered eating.Key Practitioner Message

The results from the current study suggest that insecure attachment leads to maladaptive schema, which in turn leads to sensitivity to rejection and subsequent disordered eating behaviour.
Attachment anxiety, but not attachment avoidance, was related to greater endorsement of all five schemas in the disconnection and rejection domain.
Path analysis revealed that, of the schema in the disconnection and rejection domain, only emotional deprivation and abandonment were related to disordered eating.
Interpersonal and appearance‐based rejection sensitivity were significant mediators of the relationship between emotional deprivation and disordered eating as well as the relationship between abandonment and disordered eating.
Differentiating between schemas within schema domains has clinical value in further understanding the pathway to disordered eating.
The schemas of emotional deprivation and abandonment are implicated in disordered eating, suggesting the need to target these schemas in schema therapy.
Causal mechanisms of soil organic matter decomposition: deconstructing salinity and flooding impacts in coastal wetlands
Authors: Stagg Camille L. , Schoolmaster Donald R. , Krauss Ken W. , Cormier Nicole , Conner William H. 
Published: May 2017

AbstractCoastal wetlands significantly contribute to global carbon storage potential. Sea‐level rise and other climate‐change‐induced disturbances threaten coastal wetland sustainability and carbon storage capacity. It is critical that we understand the mechanisms controlling wetland carbon loss so that we can predict and manage these resources in anticipation of climate change. However, our current understanding of the mechanisms that control soil organic matter decomposition, in particular the impacts of elevated salinity, are limited, and literature reports are contradictory. In an attempt to improve our understanding of these complex processes, we measured root and rhizome decomposition and developed a causal model to identify and quantify the mechanisms that influence soil organic matter decomposition in coastal wetlands that are impacted by sea‐level rise. We identified three causal pathways: (1) a direct pathway representing the effects of flooding on soil moisture, (2) a direct pathway representing the effects of salinity on decomposer microbial communities and soil biogeochemistry, and (3) an indirect pathway representing the effects of salinity on litter quality through changes in plant community composition over time. We used this model to test the effects of alternate scenarios on the response of tidal freshwater forested wetlands and oligohaline marshes to short‐ and long‐term climate‐induced disturbances of flooding and salinity. In tidal freshwater forested wetlands, the model predicted less decomposition in response to drought, hurricane salinity pulsing, and long‐term sea‐level rise. In contrast, in the oligohaline marsh, the model predicted no change in response to drought and sea‐level rise, and increased decomposition following a hurricane salinity pulse. Our results show that it is critical to consider the temporal scale of disturbance and the magnitude of exposure when assessing the effects of salinity intrusion on carbon mineralization in coastal wetlands. Here, we identify three causal mechanisms that can reconcile disparities between long‐term and short‐term salinity impacts on organic matter decomposition.
Prediction‐based adaptive compositional model for seasonal time series analysis
Authors: Chang Kun , Chen Rong , Fomby Thomas B. 
Published: May 2017

AbstractIn this paper we propose a new class of seasonal time series models, based on a stable seasonal composition assumption. With the objective of forecasting the sum of the next ℓ observations, the concept of rolling season is adopted and a structure of rolling conditional distributions is formulated. The probabilistic properties, estimation and prediction procedures, and the forecasting performance of the model are studied and demonstrated with simulations and real examples.
Ermittlung von 3D‐Gebirgsspannungszuständen für den Brenner Basistunnel
Authors: Braun Roland , Reinhold Chris 
Published: May 2017

AbstractIm Artikel sind die Ergebnisse von In‐situ‐Spannungsanalysen im Bereich von drei Erkundungsbohrungen des Brenner Basistunnels vorgestellt. Diese basieren auf den direkten Bestimmungen des kompletten 3D‐Gebirgsspannungszustands mit Racos (Rock anisotropy characterisation on rock samples) und der minimalen Spannungskomponente mit hydraulischen Fracs sowie ergänzenden analytischen und numerischen Berechnungen. Im nördlichen Abschnitt wurde eine tektonische Seitenverschiebung mit der größten Spannungskomponente in N‐S festgestellt. Im mittleren Tunnelbereich entsprechen die (deutlich von vertikal‐horizontal abweichenden) In‐situ‐Spannungen einem Übergang zwischen tektonischer Abschiebung und Seitenverschiebung mit starker N‐S‐Kompression. Weiter südlich wurde eine tektonische Aufschiebung mit näherungsweise N‐S‐wirkender maximaler Spannungskomponente und vertikalhorizontaler Ausrichtung festgestellt. Die Orientierungen aller maximalen horizontalen Spannungsmagnituden entsprechen (übereinstimmend mit der World Stress Map) einem einheitlichen, großräumigen, tektonischen Spannungsfeld mit einer N‐S‐ bis NNW‐SSO‐Ausrichtung senkrecht zum Alpenbogen. Die festgestellten geringen Unterschiede zwischen den totalen und effektiven in‐situ‐Belastungen verdeutlichen vernachlässigbare mechanische Porendruckwirkungen in den analysierten Bereichen. Insgesamt zeigt sich (bei akkurater Berücksichtigung der jeweiligen räumlichen Ausrichtungen) eine gute Übereinstimmung der mit unterschiedlichen Verfahren ermittelten In‐situ‐Spannungen.
Large‐scale network organization of EEG functional connectivity in newborn infants
Authors: Tóth Brigitta , Urbán Gábor , Háden Gábor P. , Márk Molnár , Török Miklós , Stam Cornelis Jan , Winkler István 
Published: May 2017

AbstractThe organization of functional brain networks changes across human lifespan. The present study analyzed functional brain networks in healthy full‐term infants (N = 139) within 1–6 days from birth by measuring neural synchrony in EEG recordings during quiet sleep. Large‐scale phase synchronization was measured in six frequency bands with the Phase Lag Index. Macroscopic network organization characteristics were quantified by constructing unweighted minimum spanning tree graphs. The cortical networks in early infancy were found to be significantly more hierarchical and had a more cost‐efficient organization compared with MST of random control networks, more so in the theta and alpha than in other frequency bands. Frontal and parietal sites acted as the main hubs of these networks, the topological characteristics of which were associated with gestation age (GA). This suggests that individual differences in network topology are related to cortical maturation during the prenatal period, when functional networks shift from strictly centralized toward segregated configurations. Hum Brain Mapp 38:4019–4033, 2017. © 2017 Wiley Periodicals, Inc.
Exploring Discrimination on the Basis of International Experience: The Colonial Mindset Bias in the Context Of Pakistan
Authors: Bano Ayesha , Nadeem Sadia 
Published: May 2017

AbstractDiscrimination in the labor market has historically been associated with gender, race, ethnicity, and age. This article introduces another basis of discrimination—international experience—which may exist in developing countries because of a colonial mindset. The research is an exploratory study, based on an analysis of in‐depth semistructured interviews with 8 HR managers, 19 employees with international experience, and 24 employees without international experience (N = 51) working in the oil and gas and telecom sectors of Pakistan. Results indicate some initial evidence of a bias, and hence discrimination during recruitment for entry‐level positions. Findings also indicate that international experience may contribute to enhanced employment opportunities, career progress, and higher compensation at senior‐level leadership positions, leaving those without such experience at a disadvantage. While in some cases international experience may be a genuine occupational requirement (GOR), further research is needed to identify whether this is in fact a GOR for senior level positions in all types of organizations or indirect discrimination under the guise of GOR. Recommendations for HR managers and organizational leaders are also set out, which can be applied in practice to foster equality of opportunity in the workplace. © 2017 Wiley Periodicals, Inc.