bluuebunny/crossref_metadata_2025_split huggingface dataset:
The EP3–ZNF488 Axis Promotes Self-Renewal of Glioma Stem-Like Cells to Induce Resistance to Tumor Treating Fields
Authors: Chen Dongjiang , Le Son B. , Manektalia Harshit , Liu Tianyi , Hutchinson Tarun E. , O’Dell Adam , Salhia Bodour , Tran David D. 
Published: October 2024

Abstract
Tumor treating fields (TTFields) use low-intensity, alternating electric fields to exert antitumor activity and have demonstrated efficacy against multiple cancers, including glioblastoma (GBM). Unfortunately, cancer cells inevitably develop resistance to TTFields, highlighting the need to elucidate the underlying mechanisms to develop approaches to induce durable responses. Using a gene network–based machine learning algorithm, we interrogated TTFields-resistant GBM cells and uncovered a regulatory axis anchored by the prostaglandin E2 receptor 3 (EP3) and the transcription factor zinc finger 488 (ZNF488). Mechanistically, TTFields induced EP3 upregulation and nuclear envelope localization, where it formed a complex with ZNF488 to induce resistance to TTFields by promoting self-renewal of glioma stem-like cells (GSC). Overexpression of EP3 and/or ZNF488 in TTFields-sensitive GSC conferred resistance and enhanced self-renewal, whereas expression of noninteracting mutants of these proteins abrogated the formation of the nuclear complex and prevented resistance. Inhibition of either partner in this protein complex in resistant GSC, including those freshly isolated from TTFields-resistant GBM tumors, resensitized cells to the cytotoxic effects of TTFields, concomitant with reduced self-renewal and in vivo tumorigenicity. Importantly, inhibition of EP3 in TTFields-sensitive GSC preemptively halted the development of resistance. The EP3–ZNF488 axis was significantly upregulated in TTFields-resistant GBM tumors, and coexpression of EP3 and ZNF488 in other cancers correlated with lower survival rates. Collectively, these results indicate that the nuclear EP3–ZNF488 axis is necessary and sufficient to establish TTFields resistance, underscoring the potential to target this axis to prevent or reverse resistance in GBM and possibly other cancers.
Significance: The EP3–ZNF488 master regulatory axis in cancer stem-like cells drives resistance to treatments like tumor treating fields, opening avenues for developing strategies to enhance therapeutic efficacy.
Transient High Salt Intake Promotes T-Cell–Mediated Hypertensive Vascular Injury
Authors: Yakoub Mina , Rahman Masudur , Kleimann Patricia , Hoffe Jasmina , Feige Milena , Bouvain Pascal , Alter Christina , Kluczny Jennifer Isabel , Reidel Sophia , Nederlof Rianne , Hering Lydia , Argov Doron , Arifaj Denada , Kantauskaite Marta , Meister Jaroslawna , Kleinewietfeld Markus , Rump Lars Christian , Jantsch Jonathan , Flögel Ulrich , Müller Dominik N. , Temme Sebastian , Stegbauer Johannes 
Published: October 2024

BACKGROUND:
Dietary high salt (HS) intake has a strong impact on cardiovascular diseases. Here, we investigated the link between HS-aggravated immune responses and the development of hypertensive vascular disease.

METHODS:
ApolipoproteinE-deficient mice were transiently treated with HS (1% NaCl) via drinking water for 2 weeks, followed by a washout period, and subsequent Ang II (angiotensin II) infusion (1000 ng/kg per min for 10 days) to induce abdominal aortic aneurysms/dissections and inflammation.

RESULTS:

While transient HS intake alone triggered nonpathologic infiltration of activated T cells into the aorta, subsequent Ang II infusion increased mortality and the incidence of abdominal aortic aneurysms/dissections and atherosclerosis compared with hypertensive control mice. There were no differences in blood pressure between both groups. In transient HS-treated hypertensive mice, the aortic injury was associated with increased inflammation, accumulation of neutrophils, monocytes, CD69
+
CD4
+
T cells, as well as CD4
+
and CD8
+
memory T cells. Mechanistically, transient HS intake increased expression levels of aortic
RORγt
as well as splenic CD4
+
T
H
17 and CD8
+
T
C
1 T cells in Ang II–treated mice. Isolated aortas of untreated mice were incubated with supernatants of T
H
17, T
H
1, or T
C
1 cells polarized in vitro under HS or normal conditions which revealed that secreted factors of HS-differentiated T
H
17 and T
C
1 cells, but not T
H
1 cells accelerated endothelial dysfunction.

CONCLUSIONS:

Our data suggest that transient HS intake induces a subclinical T-cell–mediated aortic immune response, which is enhanced by Ang II. We propose a 2-hit model, in which HS acts as a predisposing factor to enhance hypertension-induced T
H
17 and T
C
1 polarization and aortic disease.
A chronometric relationship between circuits underlying learning and
error monitoring in the basal ganglia and salience network
Authors: Dias Camila , Sousa Teresa , Castelo-Branco Miguel 
Published: October 2024

Abstract
Healthy individuals readily adjust their behavior in response to errors using learning mechanisms. This raises the question of how error-related neural mechanisms underlie the learning process and its progress. In this study, 21 healthy participants performed a challenging functional magnetic resonance imaging (fMRI) task to answer this question. We assessed the evolution of error-related neural response as a function of learning progress. We tested the hypothesis that the dorsal anterior cingulate cortex (dACC) and anterior insula, key regions of the error monitoring neural circuitry, reflect both the performance of an action and its improvement. Given the nature of trial-and-error learning, we also expected an involvement of the striatum, particularly the putamen. We found that error-related neural activity (in the dACC and anterior insula) was similar following correct responses and errors in an initial learning period. However, as learning progressed, the activity continuously decreased in response to correct events and increased after errors. In opposition, during the initial learning phase, the putamen activity was modulated by errors, but, as it progressed, this region became unaffected by response outcomes. In sum, our study provides neural evidence for an interaction between the mechanisms underlying error monitoring and learning, contributing to clarifying how error-related neural responses evolve with learning.
Teaching Peace Top-down, Bottom-up, or Both? Navigating Basic Dilemmas in Cross-Cultural Conflict Resolution Education
Authors: Coleman Peter T. , Phan Lan H. , Kukreja Anupriya , Lederach John Paul 
Published: October 2024

Abstract
Despite decades of calls by the international community for the need to pivot the primary approach to cross-cultural conflict resolution education away from privileging Western, prescriptive models and methods of outside educators toward those based on the knowledge and expertise of local stakeholders, the dominant top-down paradigm persists. This article presents a new framework for cross-cultural conflict resolution education that builds on John Paul Lederach’s original distinction between prescriptive (top-down) versus elicitive (bottom-up) approaches, and extends it through grounded-theory research with expert practitioners working across cultures in conflict zones. The result is a contingency approach to working adaptively across different types of cross-cultural situations—based on five key factors—as well as insights into enacting hybrid combinations of both approaches. The implications and next steps for research and practice are discussed.
“The Sweetness of the Persian Tongue”: the Limits of Poetry in Medieval and Early Modern Georgia
Authors: Aleksidze Nikoloz 
Published: October 2024

Abstract
The history of medieval Georgian poetry is long and complicated. Placed between Persian and Byzantine commonwealths, the unification of the Georgian kingdom under the Bagratids in the eleventh century brought about a dramatic cultural revival. The formation and development of what is known as secular poetry was a reaction to the simultaneous adoption and adaptation of Persian and Byzantine elements by Georgian culture. As a result, over time, a distinct literary genre was shaped, with its own linguistic, graphic, and poetic registers – emerged, which was often contrasted with ecclesiastic writing alongside a a rigid differentiation between secular and religious writing generally and poetry specifically. The present paper identifies the origins and reasons for such a differentiation in early modern and modern political and literary discourses. While it mentions many poems from the twelfth to the seventeenth century, two relatively early theories of poetry are discussed in detail: Ephrem Mc‘ire’s (twelfth-century) reference to the “form and substance” dichotomy in poetry and Shota Rust‘aveli’s (twelfth- or thirteenth-century) vision of what does and what does not constitute proper poetry. In subsequent centuries, these discussion about the limits of poetry were integrated into identity discourses, as illustrated by the numerous sequels to and emulations of Rust‘aveli, and fed into a certain anxiety over Georgian culture within the context of total Persian dominance
Gender Persecution and the Sarah O. Case: Strengthening the Rome Statute through Domestic Trials
Authors: Benschu Livia 
Published: October 2024

Abstract
The crime of gender persecution holds great potential for the adequate prosecution of gender-based violence in international criminal law. Codified in Article 7(1)(h) of the Rome Statute as a crime against humanity, it provides an opportunity to condemn gender-specific violence beyond sexual acts. However, the icc has so far only made limited use of this possibility and has yet to convict a defendant under Article 7(1)(h) on the basis of gender. In contrast, the Düsseldorf Higher Regional Court recently became the first court or tribunal to explicitly convict a person for gender persecution. The Sarah O. case has the potential to set an important precedent for the prosecution of this crime. Importantly, it may help to highlight the challenges of prosecuting gender persecution and to address them at the national and international level.
Weakness and Pietas in Gianni Vattimo’s Weak Thought and Samuel Beckett’s “Dante and the Lobster”
Authors: Tondello Alberto 
Published: October 2024

Abstract
The following article offers an analysis of Samuel Beckett’s short story “Dante and the Lobster” through the lens of Gianni Vattimo’s weak thought. It claims that Beckett’s short story provides a more practical perspective on Vattimo’s notion of weakness and on his call for an ethics based on pietas. As it focuses on the specific vulnerability of individual entities—specifically a lobster about to be boiled alive—“Dante and the Lobster” highlights the importance of considering weakness not merely as an abstract notion but as an actual condition of beings.
Biopolitics, Conflict and Not I
Authors: Fusella Patrizia 
Published: October 2024

Abstract
Beckett’s Not I can be studied in the light of biopolitics. In this article its dramatic action is read as a power relationship where Auditor acts as an ‘apparatus’ in Agamben’s sense of the term, and Mouth as a person, understood in the sense of Esposito’s critique of personhood. In this conflict Mouth does not capitulate by means of a double praxis: ‘destituent’ and ‘instituting’: her refusal to use the pronoun ‘I’ is at the same time an action of self-desubjectification which destitutes language and thus attempts to evade biopolitical control, and an act of subjectification which transforms language and attempts to institute a new and different subject.
To Impinge Poetically
Authors: de Gaynesford Maximilian 
Published: October 2024

Abstract
Giorgio Agamben’s claim that the criterion of poetry is the possibility of enjambment helps identify characteristic and deep ways that Beckett’s poems ‘impinge poetically’, particularly the explicitly performative and self-reflective effects they achieve through enjambment-based vacillation between ends and continuities. Conversely, Beckett’s poems help amend Agamben’s overly strong interpretation of the enjambment criterion. It should imply no more than that poetry’s existence depends on the possibility of an absence of lasting accord between sound and sense, and we should acknowledge that enjambment is equally possible for a line if it is preceded by another line. Agamben’s poetry criterion also offers fresh ways to think about the relation between Beckett’s poetry and prose, with implications for his later writings.
At the End, Writing
Authors: Mukim Mantra 
Published: October 2024

Abstract
This article reads Beckett’s poems “Mort de A.D.” and “What is the Word” for how they voice and incorporate notions of formal and epistemic endings, or the lack of an ending. These two poems, written in different phases of Beckett’s career, are useful in mapping a shift in Beckett’s ‘problems’ with endings. Putting Beckett in conversation with the contemporary Italian philosophers Giorgio Agamben and Franco Berardi, specifically their analyses of “infancy” and “conjunctions” respectively, this article pays close attention to Beckett’s poetics of ending, or rather the impossibility of writing about the end.
Lipid-lowering and antioxidant properties of probiotic Bifidobacterium animalis MSMC83 in rats on a high-fat diet
Authors: Chantarangkul C. , Phuengmaung P. , Leelahavanichkul A. , Piewngam P. , Otto M. , Taweechotipatr M. 
Published: October 2024

Abstract
Hyperlipidaemia, the abnormally high concentration of lipids such as cholesterol in the body, has a series of deleterious effects on health that are least in part are due to increased inflammation and oxidative stress. Probiotics are living microorganisms that possess the efficacy to improve health. Among the many effects that have been ascribed to probiotics is the potential to lower the body lipid content. Here, we used a rat model of induced hyperlipidaemia to assess the lipid-lowering and antioxidant properties of the probiotic strain Bifidobacterium animalis MSMC83 as well as its impact on intestinal barrier immunity and the intestinal microbiota. Oral probiotic intake led to a reduction of body weight, fasting blood glucose, and lipid levels, and increased expression of cholesterol-7α-hydroxylase and antioxidant enzymes. Additionally, B. animalis MSMC83 decreased the levels of liver enzymes and pro-inflammatory cytokines, leading to reduced hepatic steatosis. Furthermore, it re-established intestinal barrier integrity as shown by restoration of the tight junction protein zonula occludens-1 amount and reduced pathogen-induced inflammation in the intestinal epithelium as shown by readjusted expression of toll-like receptors (TLRs). Moreover B. animalis MSMC83 contributed to the maintenance of a balanced, diverse microbiome. Thus, our results indicate that B. animalis MSMC83 alleviates risk factors associated with hyperlipidaemia, suggesting its use as a probiotic to counter the effects associated with unhealthy diets.
Effect of exogenous application of salicylic acid on alleviation of drought stress of immature tea (Camellia sinensis L.) plants
Authors: Damayanthi Maha Makkalage Nalika , Wijeratne Thushari Lakmini , Damunupola Jilushi Wishwamali 
Published: October 2024

Abstract
Application of salicylic acid (SA) leads to positive impacts in improving the physiological and growth parameters under drought in other crops. Knowledge on SA regulation on tea is scanty but important especially under drought. Therefore, potential of minimizing the drought effects on tea via exogenous application of SA was studied in a glasshouse at the Tea Research Institute, Talawakelle, Sri Lanka, using one-year-old potted tea cultivars of known drought tolerance (TRI 2025 – tolerant and TRI 2023 – susceptible). Plants were exposed to a drying cycle while they were foliar sprayed with SA in various concentrations (0, 50, 100, 150 and 200 ppm) along with well-watered and no-spray treatments. Data were collected at 18 hours and 3, 7, 14 and 21 days after applying the treatments from randomly selected plants. Physiological parameters were measured along with soil moisture content. Drought stress led to declining of gas exchange parameters (rate of net photosynthesis, transpiration and stomatal conductance), leaf relative water content and increasing accumulation of osmolytes (total soluble sugar and proline) in both tea cultivars compared with well-watered plants. Exogenous application of 150 and 200 ppm SA significantly improved physiological parameters. These results revealed the role of exogenous application of 150 and 200 ppm SA in diminishing the negative effects of drought on tea plants. Exogenous application of SA 150 ppm will therefore be more effective in alleviating the drought impact on immature tea when considering the environmental impact and cost effectiveness.
Projected Effects of Climate Change on Meteorological Droughts over China: A Study Based on High-Resolution NEX-GDDP Data
Authors: Cao Fuqiang , Long Xiaoyu , Gao Tao , Li Ming , Zhan Junjie , Zhou Ming 
Published: October 2024

Abstract
While historical observations reveal increases in meteorological drought frequency across China during 1960–2021, future drought characteristics at the regional scale are uncertain. We evaluate historic and twenty-first-century-projected dryness changes using the NASA Earth Exchange Global Daily Downscaled Projections (NEX-GDDP) 0.25° resolution dataset for representative concentration pathways (RCPs) 4.5 and 8.5. The 20-model NEX-GDDP ensemble mean precipitation and derived potential evapotranspiration, which is calculated by utilizing the Thornthwaite approach, are consistent with gridded station data over China from 1961 to 2005. Results show that the projections of occurrence frequency of moderate drought based on the standardized precipitation evapotranspiration index (SPEI) increase remarkably under the RCP4.5 scenario, and a significant increasing frequency is seen for severe drought under the RCP8.5 scenario, while few droughts of extreme dryness occur during the twenty-first century under both emission scenarios. More moderate drought projections are found over northwestern, northern, and southeastern regions under the RCP4.5 scenario, but all of China will face severe droughts for RCP8.5. The areas affected by moderate droughts begin to extend rapidly around 2030s at both national and regional scales for the RCP4.5 scenario, and the substantial increases in drying area extension for RCP8.5 appear around the 2050s. Particularly, the severe drought areas are found to grow much more sharply after the 2070s under the RCP8.5 scenario, implying that the occurrences of severe droughts over China are more sensitive to greenhouse gas emissions.

Significance Statement
Both temperature and rainfall are closely associated with drought variability; therefore, this study examines the changes in frequency and intensity of projected droughts across China based on the standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI). Severe droughts are projected to increase over most of the regions according to SPEI. The substantial increases in moderate and severe droughts are seen over all of China under the RCP4.5 and RCP8.5 scenarios, respectively. At the temporal scale, most of the areas are projected to experience more severe droughts by the end of twenty-first century, while the areas of moderate droughts are projected to exhibit fluctuating variations during the twenty-first century. These results indicate more future droughts, which may increase the vulnerability of more areas of China from exposure to the consequences of global warming.
Recognizing Race: Podcasting to Promote Critical Dialogue and Self-Reflection in Multicultural Psychology
Authors: Thelamour Barbara , Chang Doris 
Published: October 2024

Introduction Courses in multicultural psychology can provide content about power, privilege, healing, and resistance, especially as they pertain to race, while presenting space for students to reflect on their own socialization experiences and the role of race in their lives. Statement of Problem Direct, lecture-based approaches to presenting course content on race and racial identity can impede deep reflection and application of the material to students’ lives and their ability to engage across differences. Literature Review Critical dialogue among classroom peers enables students to use the knowledge gained from classroom content to discuss the complexity of race and racism with nuance and depth. Teaching Implications In this article, we describe Recognizing Race, a podcast assignment that scaffolds students’ self-reflection about their racial identity development while facilitating critical racial dialogues between students. Conclusion The Recognizing Race podcast assignment is one that can be used for undergraduate and graduate-level students in multicultural psychology to apply racial identity concepts to increase cultural self-awareness and promote more compassionate and inclusive interactions with others.
“If I Stay Quiet, the Only Person That Gets Hurt Is Me”: Anti-Asian Racism and the Mental Health of Chinese-Canadian Youth During the COVID-19 Pandemic
Authors: Ng Isabella , Hilario Carla , Salma Jordana 
Published: October 2024

Background and Purpose Despite documented accounts of racial discrimination against Chinese communities during the COVID-19 pandemic, few studies have examined experiences of racism among Canadian youth. This qualitative study explored the experiences of Chinese-Canadian youth during the COVID-19 pandemic and their mental health. Methods A qualitative descriptive research design, informed by Critical Race Theory (CRT), was used for this study. Data was collected using focus groups and image-based elicitation methods. Youth who self-identified as Chinese-Canadian, aged 18–24, and who experienced some account of self-defined racism were included. We analyzed the data using a coding system developed for this study and formulated key themes. Results Our analysis identified three themes: (I) Becoming racialized; (II) Learning the rules of racism; and (III) Effects of racism on mental health. We discuss findings in relation to the model minority stereotype, intersectionality of race and gender, and factors leading to a lack of support. Conclusions This study provides evidence that racism had immediate and prolonged effects on the mental health of Chinese-Canadian youth and their relationships with peers, family, and even strangers. Our research suggests the need for enhanced services for Chinese-Canadian youth and other groups experiencing racism.