bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive function, treatment response to lithium, and social functioning in Japanese patients with bipolar disorder
Authors: Saito Satoshi , Fujii Kumiko , Ozeki Yuji , Ohmori Kenichi , Honda Gyo , Mori Harunobu , Kato Kazuko , Kuroda Jinichi , Aoki Akiko , Asahi Haruhiko , Sato Hayato , Shimoda Kazutaka , Akiyama Kazufumi 
Published: July 2017

ObjectivesPatients with bipolar disorder often suffer from cognitive impairment that significantly influences their functional outcome. However, it remains unknown whether lithium has a central role in cognition and functional outcome. We examined whether cognition and functional outcome were predicted by demographic and clinical variables, including the response to lithium, in lithium‐treated patients with bipolar disorder.MethodsWe evaluated 96 lithium‐treated euthymic patients with bipolar disorder and 196 age‐ and‐gender‐matched healthy controls, using the Brief Assessment of Cognition in Schizophrenia (BACS). The patients were also assessed using the Social Functioning Scale (SFS) and “The Retrospective Criteria of Long‐Term Treatment Response in Research Subjects with Bipolar Disorder” (Alda) scale, which was evaluated as either a continuous measure of the total scale or a dichotomous criterion.ResultsMultiple regression analysis revealed two key findings: first, that the premorbid intelligence quotient, age, and number of mood episodes were predictors of the BACS composite score; and, second, that the BACS composite score, negative symptoms, and continuous measure on the total Alda scale (but not its dichotomy) predicted the total SFS score. Structural equation modeling (SEM) was used to confirm these findings, and additionally revealed that the Alda scale was significantly associated with negative symptoms and also the number of mood episodes, regardless of how it was evaluated.ConclusionsSEM delineated how demographic and clinical variables, cognitive performance, and response to lithium treatment were causally associated with, and converged on, social function. The putative role of the Alda scale for social function warrants further study.
Validation of an algorithm identifying incident primary immune thrombocytopenia in the French national health insurance database
Authors: Mezaache Salim , Derumeaux Helene , Ferraro Pierre , Capdepon Pascal , Steinbach Jean‐Christophe , Abballe Xavier , Palas Deborah , Saichi Nabil , Desboeuf Karine , Lapeyre‐Mestre Maryse , Sailler Laurent , Moulis Guillaume 
Published: July 2017

AbstractObjectivesTo evaluate the accuracy of an algorithm identifying newly diagnosed immune thrombocytopenia (ITP) patients in the French national health insurance database (SNIIRAM).MethodsThe source of data was the SNIIRAM of Midi‐Pyrenees region (southwest of France, three million inhabitants). Data of patients with at least one ITP code (D69.3 code of the International Classification of Disease, version 10) were extracted between January 1, 2012, and December 31, 2014. We used an algorithm that identifies newly diagnosed primary ITPs. Medical charts of incident ITPs were reviewed. Positive predictive values (PPVs) of identification of true, incident, and primary ITP cases were estimated.ResultsOf the 168 patients selected, 161 were true ITP cases yielding a PPV of 95.8% (95% confidence interval—95% CI: 92.8‐98.8). Among them, 128 were truly incident according to symptom onset date and 134 according to the diagnosis date yielding PPVs of 79.5% (95% CI: 73.2‐85.7) and 83.2% (95% CI: 77.4‐89.0), respectively. Median time between estimated diagnosis date by the algorithm and true diagnosis date was 0 days (interquartile range: 0 to 15).ConclusionsThis study showed a very good PPV of this algorithm identifying incident primary ITP patients in the SNIIRAM.
Cerebral vasospasm in acute porphyria
Authors: Olivier P. , Van Melkebeke D. , Honoré P.‐J. , Defreyne L. , Hemelsoet D. 
Published: July 2017

Background and purposePorphyrias are a group of inherited metabolic disorders resulting from a specific deficiency along the pathway of haem biosynthesis. A clinical classification distinguishes acute from non‐acute porphyrias considering the occurrence of life‐threatening neurovisceral attacks, presenting with abdominal pain, neuropsychiatric disturbance and neuropathy. Vasospasm is a very rare complication that can occur in all major types of acute porphyria.MethodsWe describe a porphyric crisis with vasospasm in a woman with previously undiagnosed acute porphyria. Furthermore we performed a systematic review by searching the electronic database Pubmed/MEDLINE for additional data in published studies of vasospasm in acute porphyria.ResultsOverall, 9 case reports reporting on 11 patients who suffered vasospasm during an exacerbation of acute porphyria were identified. All of the reported patients were women and the mean age was 29.4 years. When brain MRI was performed, T2‐hyperintense lesions, consistent with ischaemic changes, were observed in most patients (10/11, 91%). Although the genetic pathogenesis of the disease is well understood, the precise mechanisms to explain neurologic involvement in acute porphyria remain unclear.ConclusionAcute porphyria is an unusual and rare cause of vasospasm. However, considering porphyria in patients with unexplained cerebral vasospasm, especially in women of childbearing age, is crucial given the severity of possible complications and the available treatment options.
Microgeographic differentiation in thermal performance curves between rural and urban populations of an aquatic insect
Authors: Tüzün Nedim , Op de Beeck Lin , Brans Kristien I. , Janssens Lizanne , Stoks Robby 
Published: July 2017

AbstractThe rapidly increasing rate of urbanization has a major impact on the ecology and evolution of species. While increased temperatures are a key aspect of urbanization (“urban heat islands”), we have very limited knowledge whether this generates differentiation in thermal responses between rural and urban populations. In a common garden experiment, we compared the thermal performance curves (TPCs) for growth rate and mortality in larvae of the damselflyCoenagrion puellafrom three urban and three rural populations. TPCs for growth rate shifted vertically, consistent with the faster–slower theoretical model whereby the cold‐adapted rural larvae grew faster than the warm‐adapted urban larvae across temperatures. In line with costs of rapid growth, rural larvae showed lower survival than urban larvae across temperatures. The relatively lower temperatures hence expected shorter growing seasons in rural populations compared to the populations in the urban heat islands likely impose stronger time constraints to reach a certain developmental stage before winter, thereby selecting for faster growth rates. In addition, higher predation rates at higher temperature may have contributed to the growth rate differences between urban and rural ponds. A faster–slower differentiation in TPCs may be a widespread pattern along the urbanization gradient. The observed microgeographic differentiation in TPCs supports the view that urbanization may drive life‐history evolution. Moreover, because of the urban heat island effect, urban environments have the potential to aid in developing predictions on the impact of climate change on rural populations.
A new expression for crack opening stress determined based on maximum crack opening displacement under tension–compression cyclic loading
Authors: Chen J. J. , You M. , Huang Y. 
Published: July 2017

AbstractThe maximum crack opening displacement is introduced to investigate the effect of compressive loads on crack opening stress in tension–compression loading cycles. Based on elastic–plastic finite element analysis of centre cracked finite plate and accounting for the effects of crack geometry size, Young's modulus, yield stress and strain hardening, the explicit expression of crack opening stress versus maximum crack opening displacement is presented. This model considers the effect of compressive loads on crack opening stress and avoids adopting fracture parameters around crack tip. Besides, it could be applied in a wide range of materials and load conditions. Further studies show that experimental results of da/dN − ΔK curves with negative stress ratios could be condensed to a single curve using this crack opening stress model.
Thermal properties and formation mechanism of h‐BN nanoneedles synthesized via carbothermic reduction reaction
Authors: Ahmed Yasser Momtaz Zak , El‐Sheikh Said Moawad , Abd Allah Asmaa Abd‐El‐Baset , Anwar Said 
Published: July 2017

AbstractHexagonal boron nitride (BN) was synthesized through the carbothermic reduction reaction (CRR) of boric acid using lactose as a carbon source under the nitrogen atmosphere at 1500°C for 3 hours. The boron/carbon (B/C) molar ratio was controlled during the CRR, and the produced samples were investigated by XRD diffraction pattern, FTIR analysis, and Raman spectra. Boron carbide (B4C) was formed in samples that have a higher carbon content, in addition to boron nitride. While boron nitride pure sample was produced from lower carbon content samples. Formation of B4C was found to depend on the B/C molar ratio. The morphology of the produced powder was also investigated by SEM and TEM, which revealed that the samples consist of nanoneedles of BN and hexagonal particles of B4C. The vapor‐solid (VS) reaction mechanism was processed greatly with increasing boron amount, producing boron nitride nanoneedles, which compete with the liquid‐solid (LS) reaction mechanism. The physicochemical properties of the produced samples were studied by DTA, UV, PL, and AC impedance measurements, and revealed that the samples are promising to many proper applications.
Thermal shock resistance and hoop strength of triplex silicon carbide composite tubes
Authors: Kim Daejong , Lee Donghee , Lee Sanghwan , Park Kwangheon , Lee Hyeon‐Geun , Park Ji Yeon , Kim Weon‐Ju 
Published: July 2017

AbstractMulti‐layered SiC composites have been considered as a nuclear fuel cladding material of light water reactors, LWRs, because of their excellent high temperature strength and corrosion resistance under accident conditions. During a design basis accident of a LWR such as a loss‐of‐coolant accident, the peak temperature of the fuel clad rapidly increases as the production of decay heat continues. The emergency core cooling systems then automatically supply the reactor core with emergency cooling water. The fuel clad consequently suffers from thermal shock. In this study, the structural integrity of multi‐layered SiC composite tubes after thermal shock was investigated. Several kinds of multi‐layered SiC composite tubes consisting of CVD SiC and CVI SiCf/SiC were water‐quenched from 1200°C to room temperature. The triplex SiC composite tube retained its tubular geometry during quenching. The strength degradation after thermal shock was <13% for the specimens with a PyC interphase. The residual stress distribution within the tubes during thermal shock was evaluated by a finite element method.
Seniors centre‐based health intervention programmes in the United States and South Korea: A systematic review
Authors: Song Misoon , Seo Kyoungsan , Choi Suyoung , Choi Jeongshil , Ko Hana , Lee Soo Jin 
Published: July 2017

AbstractBackgroundDespite the great need for health interventions among seniors centre participants, this matter has received little attention.Aim and designThis systematic review aimed to identify what types of health interventions are effective and feasible for seniors centre participants.Data sourcesMEDLINE, Ovid, CINAHL, Google Scholar, EMBASE, and RISS were searched.Review methodsWe searched for health intervention studies conducted in seniors centres published in English and Korean between 1990 and 2014. Of 907 screened articles, 22 studies of all types of experimental designs were selected.ResultsSelected studies were grouped by intervention domain: health promotion (n = 8), safety (n = 5), chronic disease management (n = 6), and comprehensive wellness (n = 3). Overall, 59.1% of the interventions were provided by nurses. The health interventions resulted in positive effects on seniors centre participants' knowledge, health behaviours, clinical indices, and hospitalization rates. Few studies reported on feasibility outcomes such as satisfaction and cost‐effectiveness.ConclusionsConsidering the impact and ease of access to older people at seniors centres, health interventions and services within seniors centres should be strengthened. There is potential for nursing to spearhead seniors centre health intervention programmes to enhance active ageing for participants.
Long‐term efficacy and safety of aromatase inhibitor use for leiomyomatosis peritonealis disseminata
Authors: Ando Hitomi , Kusunoki Soshi , Ota Tsuyoshi , Sugimori Yayoi , Matsuoka Shozo , Ogishima Daiki 
Published: July 2017

AbstractLeiomyomatosis peritonealis disseminata is a rare disease characterized by pelvic smooth‐muscle nodules of various sizes. It is sometimes misdiagnosed as ovarian or peritoneal carcinoma metastasis; therefore, surgical excision for pathological diagnosis is required. Treatment options include bilateral salpingo‐oophorectomy (BSO), gonadotrophin‐releasing hormone agonist therapy, and aromatase inhibitor therapy. All of these suppress estrogen levels, but a standard treatment has not been established. A 40‐year‐old woman had multiple pelvic tumors, suspicious for ovarian cancer. She underwent laparotomy, where frozen sections of the nodules revealed leiomyomatosis peritonealis disseminata. After she completed gonadotrophin‐releasing hormone agonist therapy, we performed a total abdominal hysterectomy and BSO with residual‐nodule resection, but the nodules recurred 6 months after surgery. We then started letrozole, and 3 years have now elapsed without nodule enlargement or development of new lesions. The long‐term use of aromatase inhibitor therapy is thought to be effective and safe for patients with recurrence after BSO.
Intra‐ and post‐partum acute aortic dissection (Stanford type B): Report of two cases
Authors: Tsuritani Mitsuhiro , Kamiya Chizuko A. , Sawada Masami , Horiuchi Chinami , Iwanaga Naoko , Yoshimatsu Jun 
Published: July 2017

AbstractPregnancy with Marfan syndrome (MFS) presents challenges to the clinician because of the increased incidence of maternal cardiovascular complications, including acute aortic dissection (ADD) and the involvement of the fetus owing to the urgency of the need for surgery and the low likelihood of survival with premature delivery. Patient 1 was a 36‐year‐old pregnant Japanese woman with MFS who was referred at 16 gestational weeks with aortic root diameter 35.1 mm. Stanford type B AAD occurred on delivery without evident blood pressure changes. Patient 2 was a 31‐year‐old pregnant Japanese woman with MFS with aortic root diameter 28.3 mm at 20 gestational weeks after David procedure. Ultimately fatal Stanford type B AAD occurred on post‐partum day 15. Both patients were treated with beta‐blockers when AAD occurred. Although these two patients were initially considered to have relatively low risk according to previous reports and guidelines, AAD occurred. It is very important to provide information about these high pregnancy risks to women with MFS before conception, and to follow MFS pregnancies with great caution.
Efficacy of the oral neurokinin‐1 receptor antagonist aprepitant for nausea and vomiting induced by cisplatin and carboplatin in Japanese patients with gynecological cancer
Authors: Ikeda Masae , Shida Masako , Hirasawa Takeshi , Muramatsu Toshinari , Mikami Mikio 
Published: July 2017

AbstractAimThis study was conducted to evaluate the efficacy and the difference in effects of the oral neurokinin‐1(NK‐1) receptor antagonist aprepitant for chemotherapy‐induced nausea/vomiting (CINV) in Japanese patients with gynecological cancer receiving highly emetogenic (cisplatin) and moderately emetogenic (carboplatin) chemotherapy.MethodsAprepitant was added during the second course of chemotherapy in Japanese patients with grade ≥ 2 (Common Terminology Criteria for Adverse Events, version 3.0) nausea and vomiting during the first course despite receiving antiemetic therapy (a first‐generation 5‐hydroxytryptamine 3 receptor antagonist + dexamethasone), and in patients who requested stronger antiemetic therapy despite only having grade 1 nausea and vomiting. The incidence of nausea and vomiting was compared between the first and second courses in each group.ResultsNinety‐six (55.5%) out of 173 patients received add‐on therapy with aprepitant. There was a significant increase in the complete response (CR: no vomiting or salvage therapy) rate in the patients receiving aprepitant, with marked improvement being confirmed for delayed CINV. Stratified analysis showed that patients with delayed CINV treated with carboplatin had a significantly higher CR rate, while patients with both acute and delayed CINV treated with cisplatin had significantly higher CR rates. There was a positive correlation between the incidence of nausea and the incidence of vomiting in the patients treated with aprepitant.ConclusionThe oral NK‐1 receptor antagonist aprepitant could be effective for both acute and delayed CINV with cisplatin and for delayed CINV with carboplatin in Japanese gynecological cancer patients.
Alternative products for Pratylenchus brachyurus and Meloidogyne javanica management in soya bean plants
Authors: Miamoto Angélica , Silva Monique Thiara Rodrigues e , Dias‐Arieira Claudia Regina , Puerari Heriksen Higashi 
Published: July 2017

AbstractNematodes stand out among the main soya bean yield limiting factors due to limitations in the main control methods, mainly when they are applied alone. Given the need of finding new control techniques, the aim of this study was to assess the efficiency of products based on biological control agents and on nutrients or products showing potential to induce resistance for Pratylenchus brachyurus and Meloidogyne javanica control in soya bean plants. The experiments were conducted in a greenhouse; nine treatments with six repetitions for each nematode were assessed in two distinct periods. Overall, all treatments have shown potential to control the nematodes in at least one experiment, mainly the ones containing biological control agents (Trichoderma and Bacillus). The vegetative development results were inconclusive; however, some products have shown potential to improve the growth of infected plants.
Sleep disturbance by pramipexole is modified by Meis1 in mice
Authors: Salminen Aaro V. , Schormair Barbara , Flachskamm Cornelia , Torres Miguel , Müller‐Myhsok Bertram , Kimura Mayumi , Winkelmann Juliane 
Published: July 2017

SummaryMeis homeobox 1 (Meis1) is a transcription factor functioning in the development of the nervous system and the cardiovascular system. Both common and rare variants within the gene have been associated with restless legs syndrome (RLS), while its association with symptoms of insomnia has also been discovered recently. RLS is associated with sleep disturbances, and while Meis1 haploinsufficiency is one of the most promising strategies for an RLS animal model, sleep phenotyping of Meis1 knockout mice has never been conducted. We report a detailed sleep analysis of heterozygous Meis1 knockout mice and challenge it with pramipexole, a dopamine agonist used in the treatment of RLS. At baseline, the Meis1‐haploinsufficient mice had a trend towards lower delta power in the electroencephalogram (EEG) during sleep compared to the wild‐type littermates, possibly indicating reduced sleep quality, but not sleep fragmentation. Pramipexole had a sleep disrupting effect in both genotype groups. In addition, it exerted differential effects on the EEG power spectra of the two mouse lines, remarkably elevating the theta power of the mutant mice during recovery more than that of the wild‐types. In conclusion, Meis1 haploinsufficiency seems to have only a modest effect on sleep, but the gene may interact with the sleep‐disrupting effect of dopamine agonists.
The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Authors: Kendall Mark C. , McCarthy Robert J. , Panaro Steve , Goodwin Emily , Bialek Jane M. , Nader Antoun , De Oliveira Gildasio S. 
Published: July 2017

AbstractObjectiveTo compare the incidence in postsurgical persistent pain following breast cancer surgery in women receiving intravenous lidocaine compared to saline using validated pain instruments in accordance with the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommendations.MethodsThe study was a randomized, double‐blinded, placebo‐controlled, clinical trial. Subjects were randomized into Group 1 (1.5 mg/kg bolus of intravenous lidocaine followed by a 2 mg/kg/hour infusion) or Group 2 (normal saline at the same bolus and infusion rate). Patients were evaluated at 3 and 6 months for the presence of chronic persistent postsurgical pain.ResultsOne hundred forty‐eight patients were included in the study analysis. There were no differences in quality of recovery, pain burden, or opioid consumption between groups at 24 hours. Pain (yes/no) at 6 months attributed to surgery was reported in 29% of Group 2 vs. 13% of Group 1 patients (P = 0.04); however, only 3 subjects (5%) in Group 1 and 2 subjects (3%) in Group 2 met IMMPACT criteria for persistent postoperative pain (P = 0.99).DiscussionPerioperative infusion of lidocaine has been reported to decrease the incidence of postsurgical pain at 3 and 6 months following mastectomy using dichotomous (yes/no) scoring. Although intravenous lidocaine reduced the reported incidence of pain at rest at 6 months, pain with activity, pain qualities, and the physical or emotional impact of the pain were unaffected. Future studies evaluating postsurgical persistent pain should adhere to the IMMPACT recommendations in order to more accurately describe the effect of an intervention on persistent pain.
Reproductive performance of immobilized cryopreserved bovine semen used for timed artificial insemination
Authors: Alm‐Kristiansen AH , Dalen G , Klinkenberg G , Bekk L , Thorkildsen LT , Waterhouse KE , Kommisrud E 
Published: July 2017

ContentsThe SpermVital® technology comprises embedding of spermatozoa within an alginate gel to facilitate release of sperm cells over a prolonged period in utero after AI. The aim of this study was to examine whether the survival time of spermatozoa is extended when applying this immobilization technology in combination with cryopreservation. Sperm cell survival (acrosome and plasma membrane integrity) was studied in vitro for 48 hr at physiological temperature. One dose of SpermVital® (SV) semen was compared with single doses of Biladyl® (B) processed semen as well as double doses of B (B double). B double was obtained by adding a second B dose the following day, thereby mimicking double AI. Furthermore, reproductive performance applying single early timed AI (TAI) with SV following oestrus synchronization was studied in a field trial. Double insemination (TAI on two consecutive days) with B semen served as control. Number of acrosome‐intact live sperm cells decreased over time in vitro for all treatments (p < .05). There was no difference between SV sperm cell survival and B double after 24 hr (p > .05). However, after 48 hr, SV sperm cell survival was higher than B double (p < .05). Moreover, multivariate analysis showed that the outcome of single early TAI with SV was not significantly different from B double (p > .05). Likelihood of pregnancy and calving in the heifer group was higher than in the cow group (p < .05). These results imply that spermatozoa immobilized in alginate gel have prolonged survival.