bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal target-enrichment baits for anthozoan (Cnidaria) phylogenomics: New approaches to long-standing problems
Authors: Quattrini A.M. , Faircloth B.C. , Dueñas L.F. , Bridge T.C.L. , Brugler M. , Calixto-Botía I.F. , DeLeo D.M. , Forêt S. , Herrera S. , Lee S. , Miller D.J. , Prada C. , Rádis-Baptista G. , Ramírez-Portilla C. , Sánchez J.A. , Rodríguez E. , McFadden C.S. 
Published: August 2017

AbstractAnthozoans (e.g., corals, anemones) are an ecologically important and diverse group of marine metazoans that occur from shallow to deep waters worldwide. However, our understanding of the evolutionary relationships among the ∼7500 species within this class is hindered by the lack of phylogenetically informative markers that can be reliably sequenced across a diversity of taxa. We designed and tested 16,308 RNA baits to capture 720 Ultraconserved Element loci and 1,071 exon loci. Library preparation and target enrichment was performed on 33 taxa from all orders within the class Anthozoa. Following Illumina sequencing and Trinity assembly, we recovered 1,774 of 1,791 targeted loci. The mean number of loci recovered from each species was 638 ± 222, with more loci recovered from octocorals (783 ± 138 loci) than hexacorals (475 ±187 loci). Phylogenetically informative sites ranged from 26-49% for alignments at differing hierarchical taxonomic levels (e.g., Anthozoa, Octocorallia, Hexacorallia). The percent of variable sites within each of three genera (Acropora, Alcyonium, andSinularia) for which multiple species were sequenced ranged from 4.7-30%. Maximum likelihood analyses recovered highly resolved trees with topologies matching those supported by other studies, including the monophyly of the order Scleractinia. Our results demonstrate the utility of this target-enrichment approach to resolve phylogenetic relationships from relatively old to recent divergences. Re-designing the baits with improved affinities to capture loci within each sub-class will provide a valuable toolset to address systematic questions and further our understanding of the timing of diversifications in the class Anthozoa.
Post-transcriptional remodelling is temporally deregulated during motor neurogenesis in human ALS models
Authors: Luisier Raphaelle , Tyzack Giulia E. , Hall Claire E. , Ule Jernej , Luscombe Nicholas M. , Patani Rickie 
Published: August 2017

SUMMARYMutations causing amyotrophic lateral sclerosis (ALS) strongly implicate regulators of RNA-processing that are ubiquitously expressed throughout development. To understand the molecular impact of ALS-causing mutations on early neuronal development and disease, we performed transcriptomic analysis of differentiated human control and VCP-mutant induced pluripotent stem cells (iPSCs) during motor neurogenesis. We identify intron retention (IR) as the predominant splicing change affecting early stages of wild-type neural differentiation, targeting key genes involved in the splicing machinery. Importantly, IR occurs prematurely in VCP-mutant cultures compared with control counterparts; these events are also observed in independent RNAseq datasets from SOD1- and FUS-mutant motor neurons (MNs). Together with related effects on 3’UTR length variation, these findings implicate alternative RNA-processing in regulating distinct stages of lineage restriction from iPSCs to MNs, and reveal a temporal deregulation of such processing by ALS mutations. Thus, ALS-causing mutations perturb the same post-transcriptional mechanisms that underlie human motor neurogenesis.HIGHLIGHTSIntron retention is the main mode of alternative splicing in early differentiation.The ALS-causing VCP mutation leads to premature intron retention.Increased intron retention is seen with multiple ALS-causing mutations.Transcriptional programs are unperturbed despite post-transcriptional defects.eTOC BLURBLuisier et al. identify post-transcriptional changes underlying human motor neurogenesis: extensive variation in 3’ UTR length and intron retention (IR) are the early predominant modes of splicing. The VCP mutation causes IR to occur prematurely during motor neurogenesis and these events are validated in other ALS-causing mutations, SOD1 and FUS.
DNA sequence encodes the position of DNA supercoils
Authors: Kim Sung Hyun , Ganji Mahipal , der Torre Jaco van , Abbondanzieri Elio , Dekker Cees 
Published: August 2017

AbstractThe three-dimensional structure of DNA is increasingly understood to play a decisive role in gene regulation and other vital cellular processes, which has triggered an explosive growth of research on the spatial architecture of the genome. Many studies focus on the role of various DNA-packaging proteins, crowding, and confinement in organizing chromatin, but structural information might also be directly encoded in bare DNA itself. Here, we use a fluorescence-based single-molecule technique to visualize plectonemes, the extended intertwined DNA loops that form upon twisting DNA. Remarkably, we find that the underlying DNA sequence directly encodes the structure of supercoiled DNA by pinning plectonemes at specific positions. We explore a variety of DNA sequences to determine what features influence pinning, and we develop a physical model that predicts the level of plectoneme pinning in excellent agreement with the data. The intrinsic curvature measured over a range of ~70 base pairs is found to be the key property governing the supercoiled structure of DNA. Our model predicts that plectonemes are likely to localize directly upstream of prokaryotic transcription start sites, and this prediction is experimentally verifiedin vitro.Our results reveal a hidden code in DNA that helps to spatially organize the genome.
Fluidic actuators for separation control at the engine/wing junction
Authors: Schloesser Philipp , Meyer Michael , Schueller Martin , Weigel Perez , Bauer Matthias 
Published: August 2017

Purpose
The area behind the engine/wing junction of conventional civil aircraft configurations with underwing-mounted turbofans is susceptible to local flow separation at high angles of attack, which potentially impacts maximum lift performance of the aircraft. This paper aims to present the design, testing and optimization of two distinct systems of fluidic actuation dedicated to reduce separation at the engine/wing junction.

Design/methodology/approach
Active flow control applied at the unprotected leading edge inboard of the engine pylon has shown considerable potential to alleviate or even eliminate local flow separation, and consequently regain maximum lift performance. Two actuator systems, pulsed jet actuators with and without net mass flux, are tested and optimized with respect to an upcoming large-scale wind tunnel test to assess the effect of active flow control on the flow behavior. The requirements and parameters of the flow control hardware are set by numerical simulations of project partners.

Findings
The results of ground test show that full modulation of the jets of the non-zero mass flux actuator is achieved. In addition, it could be shown that the required parameters can be satisfied at design mass flow, and that pressure levels are within bounds. Furthermore, a new generation of zero-net mass flux actuators with improved performance is presented and described. This flow control system includes the actuator devices, their integration, as well as the drive and control electronics system that is used to drive groups of actuators.

Originality/value
The originality is given by the application of the two flow control systems in a scheduled large-scale wind tunnel test.
IT internal control weaknesses and the market value of firms
Authors: Kuhn John R. , Morris Bonnie 
Published: August 2017

PurposeWith computer technology fast becoming the engine that drives productivity, IT systems have become more pervasive in the daily operations of many businesses. Large, as well as small, businesses in the USA now rely heavily on IT systems to function effectively and efficiently. However, past studies have shown CEOs do not always understand how reliant their business is on IT systems. To the authors’ knowledge, no research has not yet examined if financial markets understand how IT affects the performance of businesses. The paper aims to discuss these issues.Design/methodology/approachIn this study, the authors utilize the event study method to examine how financial markets interpret weaknesses in businesses IT systems. The authors examine this in the context of the Sarbanes-Oxley Act – Section 404 requirements and utilize the internal reporting requirement in the annual financial statement filing with the Securities Exchange Commission as a proxy to evaluate how the financial markets interpret IT weaknesses.FindingsUsing an event study, the authors show that the market does not necessarily understand and respond to the effects of IT weaknesses on overall financial performance of firms and thus challenge the efficient market hypothesis theory.Originality/valueA second contribution is methodological in nature. IS researchers thus far have been using limited market benchmarks, statistical tests, and event windows in their respective event studies of market performance. This study shows shortcomings of that approach and the necessity of expanding usage of available event analysis tools. The authors show that using more than one market benchmark and statistical test across multiple time frames uncovers the effects that using a single benchmark and test over a single window would have overlooked.
How do top- and bottom-performing companies differ in using business analytics?
Authors: Cao Guangming , Duan Yanqing 
Published: August 2017

PurposeBusiness analytics (BA) has attracted growing attention mainly due to the phenomena of big data. While studies suggest that BA positively affects organizational performance, there is a lack of academic research. The purpose of this paper, therefore, is to examine the extent to which top- and bottom-performing companies differ regarding their use and organizational facilitation of BA.Design/methodology/approachHypotheses are developed drawing on the information processing view and contingency theory, and tested using multivariate analysis of variance to analyze data collected from 117 UK manufacture companies.FindingsTop- and bottom-performing companies differ significantly in their use of BA, data-driven environment, and level of fit between BA and data-drain environment.Practical implicationsExtensive use of BA and data-driven decisions will lead to superior firm performance. Companies wishing to use BA to improve decision making and performance need to develop relevant analytical strategy to guide BA activities and design its structure and business processes to embed BA activities.Originality/valueThis study provides useful management insights into the effective use of BA for improving organizational performance.
Bearing temperature monitoring of a Wind Turbine using physics-based model
Authors: Cambron Philippe , Tahan Antoine , Masson Christian , Pelletier Francis 
Published: August 2017

PurposeThe purpose of this paper is to propose a method to monitor a Wind Turbine’s (WT) main bearing, based on the difference between the temperature as measured by the Supervisory Control and Data Acquisition system (SCADA).Design/methodology/approachThe monitoring of the main bearing is based on the difference between the measured temperature and the estimated temperature obtained from a dynamic model. The model used is based on the law of energy conservation. Several validation metrics have suggested that this model is accurate.FindingsThe Exponentially Weighted Moving Average control chart for two cases studies is used for the monitoring for the main bearing; this method has shown great potential for industrial applications. A failure was detected three weeks before the current actual alarm settings used by SCADA were able to identify the issue.Originality/valueThe proposed method is a monitoring method that can be used on most industrial wind farms and provide important information on the condition of the WTs’ main bearing.
Bibliometric review of improvements in building maintenance
Authors: Rocha Patricia , Rodrigues Rui Calejo 
Published: August 2017

Purpose
The purpose of this paper is to review the status of knowledge on the subject of building maintenance from an integrated perspective that incorporates the building lifecycle, that is, from the design stage to the end of life. This work considered the main aspects to be taken into account in determining and implementing maintenance strategies, which requires a cross-sectional view of the entire construction process. At the same time, this approach contributes to the organisation of building management.

Design/methodology/approach
Bibliometric review has been carried out to identify relevant subjects and topics about scientific production on building maintenance by analysing the contents of about 745 publications, over the last 15 years, between 2000 and 2016 (first quarter). The survey results were gradually organised into a database grouped into seven main themes which were found to be more discussed and others six emergent themes with topics on building maintenance research.

Findings
This research enabled a synthesis of the focal points in the literature on building maintenance, as well as debates among researchers and institutions in the field. The result is a view to the future regarding what issues merit further research and what content requires greater depth of understanding, allowing us to envision research directions that encompass topics and sub-topics for future development. To this end, this bibliometric study draws on knowledge developed over the last 15 years, using research studies published in refereed journals indexed in ISI/SCOPUS as its data source.

Originality/value
The novelty of this topic, and the aspect in which it differs from existing studies, is that the researchers analysed a single sub-topic: that is, content regarding maintenance. Thus, this bibliometric literature review allows us to achieve a comprehensive and integrated view of key issues developed in the field of building maintenance. The results show which topics have been more thoroughly developed and which still exhibit gaps and weaknesses. This review allows us to envision well thought out guidelines for future development that have the potential to be relevant to progress in building maintenance research. It also contributes to our understanding of the state of the art in this field of knowledge.
Evaluating the concept specialization distance from an end-user perspective
Authors: Martín-Moncunill David , Sicilia-Urban Miguel Angel , García-Barriocanal Elena , Stracke Christian M. 
Published: August 2017

Purpose
The common understanding of generalization/specialization relations assumes the relation to be equally strong between a classifier and any of its related classifiers and also at every level of the hierarchy. Assigning a grade of relative distance to represent the level of similarity between the related pairs of classifiers could correct this situation, which has been considered as an oversimplification of the psychological account of the real-world relations. The paper aims to discuss these issues.

Design/methodology/approach
The evaluation followed an end-user perspective. In order to obtain a consistent data set of specialization distances, a group of 21 persons was asked to assign values to a set of relations from a selection of terms from the AGROVOC thesaurus. Then two sets of representations of the relations between the terms were built, one according to the calculated concept of specialization weights and the other one following the original order of the thesaurus. In total, 40 persons were asked to choose between the two sets following an A/B test-like experiment. Finally, short interviews were carried out after the test to inquiry about their decisions.

Findings
The results show that the use of this information could be a valuable tool for search and information retrieval purposes and for the visual representation of knowledge organization systems (KOS). Furthermore, the methodology followed in the study turned out to be useful for detecting inconsistencies in the thesaurus and could thus be used for quality control and optimization of the hierarchical relations.

Originality/value
The use of this relative distance information, namely, “concept specialization distance,” has been proposed mainly at a theoretical level. In the current experiment, the authors evaluate the potential use of this information from an end-user perspective, not only for text-based interfaces but also its application for the visual representation of KOS. Finally, the methodology followed for the elaboration of the concept specialization distance data set showed potential for detecting possible inconsistencies in KOS.
The lost academic home: institutional affiliation links in Google Scholar Citations
Authors: Orduña-Malea Enrique , Ayllón Juan M. , Martín-Martín Alberto , Delgado López-Cózar Emilio 
Published: August 2017

Purpose
Google Scholar Citations (GSC) provides an institutional affiliation link which groups together authors who belong to the same institution. The purpose of this paper is to ascertain whether this feature is able to identify and normalize all the institutions entered by the authors, and whether it is able to assign all researchers to their own institution correctly.

Design/methodology/approach
Systematic queries to GSC’s internal search box were performed under two different forms (institution name and institutional e-mail web domain) in September 2015. The whole Spanish academic system (82 institutions) was used as a test. Additionally, specific searches to companies (Google) and world-class universities were performed to identify and classify potential errors in the functioning of the feature.

Findings
Although the affiliation tool works well for most institutions, it is unable to detect all existing institutions in the database, and it is not always able to create a unique standardized entry for each institution. Additionally, it also fails to group all the authors who belong to the same institution. A wide variety of errors have been identified and classified.

Research limitations/implications
Even though the analyzed sample is good enough to empirically answer the research questions initially proposed, a more comprehensive study should be performed to calibrate the real volume of the errors.

Practical implications
The discovered affiliation link errors prevent institutions from being able to access the profiles of all their respective authors using the institutions lists offered by GSC. Additionally, it introduces a shortcoming in the navigation features of Google Scholar which may impair web user experience.

Social implications
Some institutions (mainly universities) are under-represented in the affiliation feature provided by GSC. This fact might jeopardize the visibility of institutions as well as the use of this feature in bibliometric or webometric analyses.

Originality/value
This work proves inconsistencies in the affiliation feature provided by GSC. A whole national university system is systematically analyzed and several queries have been used to reveal errors in its functioning. The completeness of the errors identified and the empirical data examined are the most exhaustive to date regarding this topic. Finally, some recommendations about how to correctly fill in the affiliation data (both for authors and institutions) and how to improve this feature are provided as well.
Britannica on the eve of its 250th birthday: an Encyclopedia’s metamorphosis
Authors: Danowitz Erica Swenson 
Published: August 2017

Purpose
This paper aims to explore the recent history of the Encyclopedia Britannica: how its contents evolved over the course of the twentieth and early twenty-first century, how technological changes almost led to its demise and its transformation from a print to an online source.

Design/methodology/approach
This paper traces Britannica’s history during most of the twentieth century to today using relevant literature. It also examines how Britannica’s editors used continuous revision to edit numerous print editions throughout most of the twentieth century. The author used both print and online versions of the Britannica to track how particular entries changed or remained the same over a 106-year span.

Findings
Although many Britannica entries did not change for decades, it still managed to update numerous encyclopedic articles in an age before computers and instant editing. Britannica persisted despite challenges to its existence that resulted from technological changes and imprudent business decisions. On the eve of its 250th birthday, Britannica has managed to survive as an online product that continues to educate new generations of researchers.

Originality/value
This paper examines a subject that has been explored in the past but not in recent years. Despite previous missteps and competition from Wikipedia and other online reference tools, this paper argues that Britannica still has relevance today.
Want successful employee communications? Think like a marketer
Authors: Goncalves Pam 
Published: August 2017

Purpose
Today’s employees expect a consumer-like communications experience: worthy of their time, meaningful, easy to consume, delightful and consistent. An IDG survey saw that frequent, easy-to-share, modern communications correlated positively to employees’ job satisfaction; increasing the likelihood to recommend their employer as well as to remain at their current company. Do those positive outcomes of employee satisfaction, employer brand and retention sound like they might fit into your strategic HR plans this year and every year?

Design/methodology/approach
The authors have been studying this problem for almost a decade, working with over 1,000 companies representing more than 10 million employees. It seems as if employee communications suffers from the “last mile” syndrome, a term originally coined by the telecommunications industry. You can have the most robust equipment and services but if the last mile, the final piece that connects all of that modern technology to the end user, does not get delivered, it’s all for nothing. Similarly, we can have the best HR programs, total rewards packages and a killer employer value proposition, but if they do not reach and activate our employees, HR can never realize the true ROI of that effort.

Findings
How would you rate your company’s internal communications? That was the question IDG Research asked of 270 HR professionals in its March 2017 Workforce Communication Survey. In total, 71 per cent answered yes to the prompt: “Our workplace communications are engaging”. That’s great news if you’re sitting in HR. Only 27 per cent of the corresponding 1,050 employees replied yes to that same prompt.

Originality/value
Today’s employee is on information overload – @home, @work, @anywhere. With the explosion of digital content being pushed through multiple devices, employees as digital consumers have learned to ignore some types of information and readily consume others. The authors have seen first-hand how this marketing approach to employee communications can give new life to legacy programs and most importantly, improve participation and adoption.