bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precise Relocation and Source Characterization of Two Earthquake Sequences in Yellow Sea Using Regional Lg-Wave Observations
Authors: Park Jun Yong , Kim Won-Young , Kim YoungHee , Shen Xuzhang 
Published: October 2024

ABSTRACT
Two significant earthquakes of magnitude ML 4.6 and 4.5 occurred on 18 January and 3 December 2021 in the central region of the Yellow Sea, respectively. The earthquakes occurred beneath the Gunsan sedimentary basin at about 10 km depth with a strike-slip faulting mechanism on nodal planes striking northwest–southeast (NW–SE) and north-northeast–south-southwest (NNE–SSW). Despite a lack of close-by seismographic stations, we successfully utilized regional Lg-wave observations on both coasts of the sea—the Korean peninsula on the east and eastern China on the west. For nine earthquakes in two event sequences, the Lg-wave differential travel times of the nearby event pairs at the common station are carefully measured using the waveform cross-correlation technique. The double-difference earthquake relocation method is employed to obtain precise relative epicentral locations using the Lg correlation measurements. Relocated epicenters align along the NW–SE direction, indicating that the nodal plane striking the same direction is the likely fault plane on which both sequences occurred. This is the first case reported in the literature in which the causative fault plane has been identified for earthquakes in the central Yellow Sea region. It has an important implication for current regional tectonics; it favors neither old tectonic features trending NE–SW (Qianliyan uplift) nor the north–south alignment of significant earthquakes in the region along the Amur plate boundary. The Lg waves from the earthquake sequences are dominant seismic signals on all three-component records at stations in 160–550 km and allowed us to analyze source properties of the two largest earthquakes using the empirical Green’s function approach. Azimuthal variations of the source corner frequencies suggest that earthquake rupture likely propagated toward southeast (125°) along the fault plane, supporting the aftershock relocation results.
Association of p53 expression in various molecular subtypes of invasive breast carcinoma NOS
Authors: Ilanthodi Sandhya , Hegde Samridhi , Shetty Unnatha , Rao Purnima S , Philipose Reba T 
Published: October 2024

Breast cancer is the second most common cause of mortality for women after heart disease. Consequently, stopping it is difficult at all times. Metastasis frequently occurs to distant organs such the liver, lung, and brain.All specimens from lumpectomies, simple and modified radical mastectomies, and trucut biopsies identified as Invasive Ductal Carcinoma Not Otherwise Specified at the Central Diagnostic Laboratory of the Pathology Department at tertiary care centre, were included in the study. Immunohistochemical markers were utilised and haematoxylin and eosin sections were examined.Association of p53 expression in various molecular subtypes of invasive breast carcinoma NOS. All lumpectomy specimens simple and modified radical mastectomy, trucut biopsies specimens diagnosed as invasive carcinoma breast not otherwise specified, submitted to the Department of Pathology, AJIMS, Mangalore for histopathological study are included in this study.Statistical analysis of the data was performed using SPSS 20.0.The continuous variables were presented as mean±SD. Categorical variables were presented in frequency and percentage. Categorical variables were analysed using Chi square test. A p value&#60;0.05 was considered statistically significant.This study is on the expression of p53 in invasive ductal carcinoma of the breast type NOS and correlating it with different histological grades, tumour sizes, and molecular subtypes. This study showed expression of p53 is independent of molecular subtype.
Gastric cyst of the posterior mediastinum in a child: An unusual presentation
Authors: Chandrashekar Swathi , BM Soumya , Dhale Metta , H.R Chandrasekhar 
Published: October 2024

Gastric cyst of the posterior Mediastinum is a rare congenital anomaly of the gastrointestinal tract. They are classified according to their embryological origin, epithelial lining and location, as thymic cyst, cystic hygroma, mesothelial cysts, thoracic duct cyst and cystic malformation of the primitive foregut. They usually present in neonates or in infancy and are discovered incidentally on radiological examination or gastric endoscopy. Accurate diagnosis of these cysts before resection is difficult and differential diagnosis are varied. This case report presents a 6-year-old boy who complained of fever for 3 weeks. Chest X-ray revealed right para median oval shaped opacity. HRCT showed a well-defined cystic lesion measuring 9x4.4x3.3 cm in the right side of the posterior mediastinum in the perihilar location. There was also noted vertebral segmentation anomaly in the cervicothoracic spine. Cystectomy was and Gastric cyst was diagnosed through histopathological examination. This case report is presented for its rarity and an unusual delayed clinical presentation.
A BRINCADEIRA DE PAPÉIS SOCIAIS NO PERÍODO DA IDADE PRÉ-ESCOLAR
Authors: Rodrigues Tais Vitoria , Magalhães Cassiana 
Published: October 2024

A pesquisa discute a brincadeira de papéis sociais no período da idade pré-escolar (aproximadamente 3 a 6 anos de idade). A questão norteadora do estudo foi: Como as derivações pedagógicas da Teoria Histórico-Cultural podem contribuir com a organização da brincadeira de papéis sociais para crianças de 3 a 6 anos de idade? O objetivo geral foi extrair da Teoria Histórico-Cultural subsídios teóricos para a organização do planejamento com as crianças do período pré-escolar. Utilizou-se o estudo teórico, abarcando autores clássicos da área, Elkonin (1987; 2009), Leontiev (2001; 2017), Vigotski (1996; 2008) e autores contemporâneos, Facci (2004), Cheroglu (2014), Pasqualini (2009; 2010). Os resultados revelaram a relevância da brincadeira de papéis sociais para o desenvolvimento psíquico das crianças no período da idade pré-escolar.
A CONTRIBUIÇÃO DOS JOGOS PARA EXPERIÊNCIAS EM LEITURA NA EDUCAÇÃO INFANTIL
Authors: Lima Katriel Rondon Pereira , Silva Leila Celina da , Oliveira Arao Davi 
Published: October 2024

O uso de jogos para experiências em leitura de crianças se constitui como importante ferramenta didática para o desenvolvimento da criança na educação infantil. Busca-se entender como o uso de jogos podem auxiliar nas experiências de leitura de crianças na educação infantil? Objetiva-se analisar a percepção do uso de jogos para experiências em leitura de crianças na educação infantil por uma professora atuante. Essa é uma pesquisa bibliográfica, documental e de campo com abordagem qualitativa. Como instrumento de coleta dos dados utilizou-se entrevista semiestruturada. Os dados foram analisados com base nos pressupostos de Carvalho (1992), Oliveira (1997), Alves (2004), Kishimoto (2010). Os resultados apontam que a utilização de jogos em sala de aula se mostra efetiva tanto no desenvolvimento cognitivo como no afetivo-social.
Palavras-chave: Alfabetização. Ludicidade. Jogos.
DO ESCLARECIMENTO AO GUAIÚ: A FORMAÇÃO PARA A CULTURA DA PAZ.
Authors: Caldeira Ferreira Juliani Lucinda , Muleka Mwewa Christian , Medeiros Robles Aguiar Cintia , W. O. Galindo Julyana Sueme 
Published: October 2024

O termo Guaiú é vulgarmente conhecido como balbúrdia (tumulto). Por isso nos apropriamos dele para potencializar uma reflexão sobre a instauração da cultura da paz. É somente por meio agitação, reestruturação e reorganização (tumulto), ou seja, balbúrdia, que podemos instaurar algo novo de encontro a ortodoxia das relações de violência nos ambientes de trabalho. Portanto, operamos com Guaiú tangenciado pelo conceito de esclarecimento (Adorno e Horkheimer, 1985) como instrumentos teóricos-metodológicos constituindo o que denominamos, como tese, a formação cultural Guaiú. A pesquisa, em andamento, se justifica pela busca de compreender o termo Guaiú como elemento estruturante para a Cultura da Paz em conformidade com a Lei 13.663/2018 e a Lei de Diretrizes e Bases da Educação (Lei nº 9394/96). A formação cultural Guaiú é destacada como essencial para a promoção da cultura, pois considera as complexidades subjetivas objetivadas em ambientes de trabalho da Universidade Federal de Mato Grosso do Sul (Campus Campo Grande). Operamos com a hipótese de que a formação cultural Guaiú pode potencializar a elaboração de habilidades de reconhecimento da alteridade (empatia suprahierarquica) com responsabilidade coletiva subjetivada para o atendimento das metas da ONU para Educação, Justiça, Paz e Instituições eficazes (UFMS).
Povos originários no município de Doutor Camargo no médio rio Ivaí
Authors: Mota Lucio Tadeu , Macella Marcio Augusto Uliana , Garcia Julia Mahamut 
Published: October 2024

Neste artigo, buscamos evidenciar a presença dos povos originários no município de Doutor Camargo, localizado no médio Rio Ivaí no Estado do Paraná. Apresentam-se as pesquisas arqueológicas desenvolvidas na região e no município, onde foram identificados 14 sítios arqueológicos entre 1968 e 2022, que foram georreferenciados e espacializados a fim de demonstrar que as margens do Rio Ivaí foi uma região atrativa para ocupação humana. As corredeiras do rio foram locais preciosos para a obtenção de proteína animal de peixes, aves e outros animais, suas matas fornecerem uma infinidade de bens para alimentação e abrigos. As primeiras populações de caçadores-coletores chegaram por volta de 6.500 AP, seguida da chegada dos povos ceramistas Guarani por volta de 1490 ± 45 anos AP.
Improvement the bearing capacity of the soil which is supporting the shallow foundation by using bored short micro-piles
Authors: Al-Chalabi Shaymaa khalid AbdulRahman 
Published: October 2024

في هذا البحث تم استخدام الركائز الكونكريتية القصيرة (concrete micro-piles)لتحسين قابلية تحمل التربة الساندة للأسس الضحلة عن طريق استخدام مجموعة متكونة من (9,6,4) ركائز حفر ذات نوعين من الأقطار (0.125,0.1)m واستخدام نسبة الطول إلى القطرL/D (12,10,6 )على التوالي.
لحساب قابلية تحمل الركائز القصيرة تم استخدام طريقة (Tomlinson)و طريقة(Lamda) وقد استخدمت خواص التربة الموجودة في منطقة مطار المثنى (سابقا") لغرض أستحصال النتائج(Al-Qyssi, 2001)[1]
أظهرت النتائج أنه بزيادة عدد الركائز وِ / أو زيادة أقطارها وأطوالها وتداخل تأثير تحمل الأساس الضحل مع تحمل مجموعة الركائز تؤدي الى زيادة في مقاومة الأحمال الخارجية. وأفضل النتائج كانت عندما بلغ عدد الركائز (9) ونسبةL/D مساوي الى (12) حيث وجد أن نسبة التحسن في قابلية التحمل بلغت 90%))مقارنة بتحمل أساس ضحل بأبعاد (1×1)m وبدون اضافات, ومن مقارنة النتائج ظهر أن طريقة (Tomlinson) يعطي قيم أقل من طريقة (Lamda) بمقدار ما بين 2-6)%) وأن استخدام الركائز القصيرة ذات القطر (0.125m) ونسبة الطول الى القطر (L/D=12) بعدد( 4) أفضل من استخدام الركائز ذات القطر (0.1m) بعدد( 9).
Structural characterization of gamma irradiated ZnS thin films
Authors: Habubi Nadir Fadhil , Hashim Mustafa Shakir , Al-Yasiri Amal Yousif 
Published: October 2024

باستخدام حيود الاشعة السينية تمت دراسة تأثير أشعة كاما في الخواص التركيبية لأغشية كبريتيد الخارصين الرقيقة المرسبة على قواعد من الزجاج بتقنية التبخير الوميضي الى ظهورالقمتين
(111),(220) في بطاقة الاشعة السينية دليل على التركيب التكعيبي للاغشية. ثابت الشبيكة ،الحجم الحبيبي ، معدل الاجهاد الداخلي ، المطاوعة المجهرية ، كثافة الانخلاعات ، وكانت المستويات البلورية المتسيدة قد حسبت وربطت بالتشعيع باشعة كاما.
Optimization of Hydraulic Horsepower to Reduce Total Fuel Cost
Authors: Lucsko J. , Neptune C. , DuBois K. , Segars J. 
Published: October 2024

Abstract
During hydraulic fracturing operations, the diesel fuel consumed by equipment is a major expenditure in an operator's completion program. More specifically, the diesel fuel consumed by a hydraulic fracturing fleet can account for nearly 20% of consumable costs on an average single well field ticket. By efficiently displacing diesel fuel with natural gas, an operator can reduce the cost of their completions program. This reduction in diesel fuel consumed also leads to lower carbon emissions, less pad traffic, and could ultimately result in less motor vehicle accidents and environmental issues.
A completion services company conducted a study to decrease the total fuel consumption, diesel fuel and natural gas, of a hydraulic fracturing fleet by optimizing the operating conditions of the pumping units. Expected results of this study included the determination of an operating range for both hydraulic horsepower and engine speed that would lead to the goal of decreasing total fuel consumption.
Phase one of the study began with collecting fuel consumption and hydraulic horsepower levels of a single high pressure pumping unit on a per treatment stage basis. Multiple pumping units were selected and individually tested during this phase. The units were selected based on engine hours, transmission, and pump system. All units in the fleet were powered by a Tier-II 2500HP Dual Fuel engine.
The diesel fuel and natural gas consumed by each test pump and the frac fleet during both phases were recorded using four separate Coriolis meters per stage. The diesel and natural gas supply to the entire frac fleet was measured, with an additional measurement taken for the single unit downstream of the fleet meters.
Results from the study showed that by reducing engine speed from 1950 RPM down to 1850 RPM, a decrease in fuel consumption per hour and an increase in engine efficiency was achieved.
Loss-of-function of ALDH3B2 transdifferentiates human pancreatic duct cells into beta-like cells
Authors: Yi Peng , Li Jian , Lee Yu-chi , Morrow Noelle , Hollister-Lock Jennifer , Sullivan Brooke , Stewart Taylor , Wei Siying , Pereira Jessica , Lee-Papastavros Alexander , Bonner-Weir Susan , Bode Kevin , Ma Andy , He Mulin , Pan Hui , Dreyfuss Jonathan 
Published: October 2024

Abstract

Replenishment of pancreatic beta cells is a key to the cure for diabetes. Beta cells regeneration is achieved predominantly by self-replication especially in rodents, but it was also shown that pancreatic duct cells can transdifferentiate into beta cells. How pancreatic duct cells were transdifferentiated and whether we could manipulate the transdifferentiation to replenish beta cell mass is not well understood. Using a genome-wide CRISPR screen, we discovered that loss-of-function of ALDH3B2 is sufficient to transdifferentiate human pancreatic duct cells into functional beta-like cells. The transdifferentiated cells have significant increase in beta cell marker genes expression, secrete insulin in response to glucose, and reduce blood glucose when transplanted into diabetic mice. Our study identifies a novel gene that we could potentially target in human pancreatic duct cells to replenish beta cell mass for diabetes therapy.
Effect of Intradialysis Virtual Reality Exercise in Hemodinamic Stability: Randomized Trial
Authors: Toquero-Correa Marina , Cana-Poyatos Alicia , García-Testal Alicia , Gil-Gómez José Antonio , Benavent-Bataller Vicent , Martínez-Olmos Francisco José , Ortiz-Ramón Rafael , Lavirgen-Heras Héctor , Ortiz-Sáez Natalia , Segura-Ortí Eva 
Published: October 2024

Abstract

Background:
Intradialysis exercise is recommended during the first two hours of the session to avoid hemodynamic instability, but this recommendation is a barrier for the implementation of exercise during dialysis. The main aim of this study was to evaluate the impact of intradialysis exercise in the last two hours versus the first two hours of the HD session on hemodynamic variables.
Methods
This is a randomized trial. Participants were randomized into two groups. Group A exercised within the first two hours of HD and Group B exercised within the last two hours of HD. The exercise consisted of playing a non-immersive virtual reality video game. The hemodynamic control variables (Systolic blood pressure SBP, diastolic blood pressure DBP and heart rate HR), the number of hypotension events, hypertensive crisis, and cardiac arrhythmias were recorded during the HD sessions. Other variables such as dialysis dose and molecule rebound were also recorded. A mixed linear regression model was used to analyze the results.
Results
40 patients completed the study. The SBP, DBP, and HR were compared between groups in different moments (Rest vs Exercise time) and no significant differences were shown. During the intervention period, Group A presented 16 hypotensive events, 10 hypertensive events and 1 arrhythmia event in 725 exercise sessions, while Group B presented 20 hypotensive events, 5 hypertensive events and 1 arrhythmia in 713 exercise sessions. There were no significant differences between groups. Antihypertensive drugs prescribed decreased significantly after the exercise program with similar control of SBP and HR.
Conclusion
The results showed that an intradialytic VR exercise during the last two hours of the HD session did not result in hemodynamic instability.
Combining Circadian Rhythm-Related Gene Expression and Immune Infiltration to Identify Diagnostic Biomarkers in Acute Myocardial Infarction
Authors: Yu Xiao , Zhang Xiaopeng , Bilal Hazrat , Shi Chang , Sun Lei 
Published: October 2024

Abstract

Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing the interplay between circadian rhythm-related gene expression and immune infiltration can pinpoint more accurate diagnostic biomarkers for AMI. Our results demonstrated differential expression of 15 circadian rhythm-related genes (CRGs) between AMI patients and healthy individuals, with five key genes—JUN, NAMPT, S100A8, SERPINA1, and VCAN—emerging as central to this process. Functional enrichment analyses suggest these genes significantly influence cytokine and chemokine production in immune responses. Immune infiltration assessments using ssGSEA indicated elevated levels of neutrophils, macrophages, and eosinophils in AMI patients. Additionally, we identified potential therapeutic implications with 13 pivotal miRNAs and 10 candidate drugs targeting these genes. RT-qPCR analysis further confirmed the upregulation of these five genes under hypoxic conditions, compared to controls. Collectively, our findings highlight the critical role of CRGs in AMI, offering new insights into its diagnosis and potential therapeutic targets.
Postoperative One Year Prediction for Patients with Cervical Spinal Cord Injury Based on Deep Learning and Radiomics
Authors: Lin Fabin , Wang Kaifeng , Wang Ruxian , Wu Yang , Chen Chunmei , Wang Yongjiang , Wang Rui 
Published: October 2024

Abstract

Background:
Cervical spinal cord injury (SCI) can lead to significant impairments, requiring extensive care and posing considerable challenges in predicting postoperative outcomes. This study aimed to develop and validate a deep learning radiomics (DLR) model combining deep learning and radiomics features to improve the prognostic prediction of cervical SCI.
Methods:
This retrospective study included 82 patients with confirmed cervical SCI from three hospitals, collected between January 2012 and January 2021. Patients were divided into good prognosis and poor prognosis groups based on postoperative ASIA grade improvement. Preoperative MRI images were processed using various filtering techniques, and regions of interest (ROI) were segmented and analyzed to extract radiomics features. Deep learning models (ResNet-18, ResNet-50, and ResNet-101) were trained. Features from both radiomics and deep learning models were combined and selected 、 to build the final predictive model using MLP.
Results:
ResNet-50 outperformed other models, demonstrating an AUC of 0.8750 in the test set. The combined model (Rad + ResNet-50) showed the highest prognostic value with an AUC of 0.9220 in the test set. Grad-CAM images enhanced the interpretability of the model by highlighting critical areas for prognosis prediction.
Conclusion:
Integrating deep learning and radiomics features significantly improves the prediction accuracy for cervical SCI outcomes. The Rad + ResNet-50 model, with its superior performance and interpretability, holds promise for clinical applications, offering a robust tool for predicting functional prognosis in cervical SCI patients. Further prospective studies with larger datasets are needed to validate these findings.
Association between Moyamoya Disease and Open-Angle Glaucoma: A Nationwide Cohort Study in Korea
Authors: Kim Min Seok , Lee Eun Ji , Lee Si Un , Kim Tae-Woo , Park Sang Jun , Woo Se Joon , Lee Jeongwoo , Nam Seonghee , Joo Kwangsic 
Published: October 2024

Abstract

This nationwide population-based retrospective cohort study aims to investigate the association between Moyamoya disease (MMD) and open-angle glaucoma (OAG). In this study using the Korean National Health Insurance Service database, a total of 40,253 patients having diagnostic code with MMD between 2002 and 2022, and their age-, sex-matched non-MMD controls (n = 400,033) were included. For the primary outcome, logistic regression analysis was performed to determine the association between MMD and OAG. For the secondary outcome, we used a Cox proportional hazard model after excluding cases with preexisting diagnosis of MMD for the initial 2-year. Kaplan-Meier survival analyses with log-rank test were performed to compare the incidence probability of OAG based on the MMD diagnosis. Logistic regression analysis revealed a significant association between MMD and OAG (OR, 1.45; 95% CI, 1.36–1.54; P < 0.001), consistent across adjusted model (OR, 1.15; 95% CI, 1.07–1.23; P < 0.001). Cox regression analysis showed that the diagnosis of MMD was associated with increased risk of subsequent diagnosis of OAG (adjusted HR, 1.26; 95% CI, 1.14–1.39; P < 0.001). The cumulative incidence probability of OAG was 3.7% in MMD group and 2.9% in control group at the end of the study period, and was significantly higher among MMD patients than controls consistently during the study period (P < 0.001). In conclusion, the nationwide longitudinal data of Korean population revealed a significant association between MMD and OAG. Presence of MMD may increase the risk of developing OAG.
Construction and validation of a nomogram to predict frailty in Chinese patients with hypertension: evidence from the China Health and Retirement Longitudinal Study (CHARLS)
Authors: Wu Guiping , Wu Huarong , Shen Zexue , Chen Ruizhe , Che Xiaowen 
Published: October 2024

Abstract

Background
Frailty is common in patients with hypertension and predisposes patients to poor postoperative outcomes. However, there is a lack of a prediction model for frailty in patients with hypertension. Therefore, we established a nomogram to identify those at risk for frailty in hypertension, providing implications for health interventions and community services.
Methods
The patients diagnosed with hypertension were collected from the the China Health and Retirement Longitudinal Study (CHARLS) database and were randomly divided into a training cohort and a validation group at a ratio of 7:3. The independent risk factors of frailty were determined by LASSO regression and multivariable logistic regression and a nomogram predict model for frailty was established. The performance of the nomogram was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC), calibration curve, and decision curve analysis (DCA).
Results
The content of the nomogram includes age, health status, cognitive function, and the Center for Epidemiological Studies Depression (CES-D). The AUCs of the training cohort and validation cohort (0.830 and 0.854) suggested good discrimination of the nomogram. Calibration curves and DCA curves proved accuracy and clinical applicability.
Conclusion
The nomogram we created for the frailty in hypertensive patients had good performance and applicability, which could help clinicians in the medical decision-making process.