bluuebunny/crossref_metadata_2025_split huggingface dataset:
EMG correlations of edentulous patients with implant overdentures and fixed dental prostheses compared to conventional complete dentures and dentates: a systematic review and meta‐analysis
Authors: von der Gracht Ina , Derks Andreas , Haselhuhn Klaus , Wolfart Stefan 
Published: June 2016

AbstractObjectivesThe goal of this meta‐analysis was to evaluate how muscular activity, measured by electromyography (EMG), differs among edentulous patients treated with a complete denture (CD), removable implant overdentures (IO), implant‐retained fixed dental prostheses (IFDP), and dentates. The differences during clenching and chewing were of particular interest.Materials and MethodsAn electronic literature review was carried out on MEDLINE (Pubmed) and the Cochrane Library covering the period January 1980 through September 2013. This was accomplished independently by three different reviewers and supplemented by a manual search. The review included randomized controlled trials, controlled clinical trials, and clinical trials which evaluated surface electromyography, bite force, chewing, and implants or complete dentures. In addition, the research was adjusted using MeSH terms.ResultsThe search garnered 646 titles and abstracts. Sixteen articles which met the inclusion criteria were analyzed. The effect size for muscular activity after implant support increased after therapy during clenching 2.18 (95% CI: 1.14, 3.23) and during chewing 1.45 (95%CI: 1.21, 1.69). Moreover, the EMG data of IO and IFDP groups (pooled) were lower than that of dentate control subjects during clenching (effect size: −1.01 [95%CI: −1.37, −0.65]). In contrast, the IFDP‐wearers showed higher values than dentates during chewing. Among the edentulous control patients, the IO and IFDP groups (pooled) displayed higher values during clenching (effect size: 1.12 [95%CI: 0.7, 1.55]) and chewing (effect size: 1.33 [95%CI: −0.57, 2.10]). Furthermore, the muscular activity during chewing correlated with the hardness of the food.ConclusionIn general, edentulous patients with CDs can achieve a greater degree of muscular activity after rehabilitation with IOs during clenching and chewing. During clenching, patients with IFDPs achieved higher values than those with dentates. The muscular activity increases with the hardness of the food.
Bleeding risk of endoscopic ultrasound‐guided fine‐needle aspiration in patients undergoing antithrombotic therapy
Authors: Inoue Tadahisa , Okumura Fumihiro , Sano Hitoshi , Kobayashi Yuji , Ishii Norimitsu , Suzuki Yuta , Fukusada Shigeki , Kachi Kenta , Ozeki Takanori , Anbe Kaiki , Iwasaki Hiroyasu , Mizushima Takashi , Ito Kiyoaki , Yoneda Masashi 
Published: June 2016

AbstractObjectivesBleeding events related to endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) are rare. However, for patients treated with antithrombotic agents, the bleeding risk of EUS‐FNA is uncertain. Hence, the aim of this study was to assess the bleeding event rate associated with EUS‐FNA in patients receiving antithrombotic treatment.MethodsA retrospective study was conducted in 742 consecutive patients who underwent EUS‐FNA for solid lesions between 2008 and 2015. We compared the bleeding event rates among patients who were not administered antithrombotic agents, those whose agent use was discontinued, those who continued treatment with aspirin or cilostazol, and those who were administered heparin as a replacement.ResultsThere were 131 patients (17.7 %) treated with antithrombotic agents. Seven experienced bleeding events, and the overall bleeding event rate was 0.9 % (7/742). All bleeding events were intraoperative; there were no postoperative bleeding episodes. Subgroup analysis by antithrombotic agent revealed bleeding event rates of 1.0 % (6/611), 0 % (0/62), 1.6 % (1/61), and 0 % (0/8) for the non‐administration, discontinuation of agents, continuation of aspirin or cilostazol, and heparin replacement groups, respectively. Only one severe bleeding event necessitated hemostatic treatment (1/742; 0.1 %); this occurred in a patient in the non‐administration group, and there were no severe bleeding events in patients receiving antithrombotic treatment.ConclusionsThe present study found a low incidence of EUS‐FNA‐related bleeding in patients receiving antithrombotic treatment. The bleeding event rate was low even in patients who underwent EUS‐FNA while continuing aspirin or cilostazol.
Behavioural Tests Reveal Severe Visual Deficits in the Strictly Subterranean African Mole‐Rats (Bathyergidae) but Efficient Vision in the Fossorial Rodent Coruro (Spalacopus cyanus, Octodontidae)
Authors: Kott Ondřej , Němec Pavel , Fremlová Aneta , Mazoch Vladimír , Šumbera Radim 
Published: June 2016

AbstractVision has long been considered purposeless in the dark underground ecotope. However, recent anatomical studies revealed an unexpected diversity of ocular and retinal features and various degrees of development of the visual system in mammals with predominantly subterranean activity, and have suggested retention of basic visual capabilities even in some strictly subterranean mammals such as the African mole‐rats. Behavioural tests assessing image‐forming vision have not yet been conducted in subterranean mammals. Here, we investigated the visual capacities in three species of the African mole‐rats, namely the giant mole‐ratFukomys mechowii, the Mashona mole‐ratFukomys darlingiand the silvery mole‐ratHeliophobius argenteocinereus, in the fossorial coruroSpalacopus cyanusand the inbred C57L/J mouse. The behavioural assays performed in this study revealed severe visual deficits in all three species of mole‐rats. The absence of the visual placing reflex suggested impairment of either image‐forming vision or visuomotor integration. The random choice between the shallow and the deep side of a visual cliff clearly demonstrated inability of mole‐rats to perceive depth. The nesting assay did not yield conclusive evidence regarding the capacity for visually guided spatial orientation in the only tested species, the giant mole‐rat. In contrast, both the coruro and the mouse exhibited a clear placing reaction and preferred the shallow side of the visual cliff, implying functional image‐forming vision. Thus, the behavioural data gathered in this study show that vision is seriously compromised in the strictly subterranean, congenitally microphthalmic African mole‐rats but efficient (i.e. comparable to that of surface‐dwelling rodents) in a species with regular surface activity, the coruro.
Fn14 deficiency protects lupus‐prone mice from histological lupus erythematosus‐like skin inflammation induced by ultraviolet light
Authors: Doerner Jessica , Chalmers Samantha A. , Friedman Adam , Putterman Chaim 
Published: June 2016

AbstractThe cytokine TNF‐like weak inducer of apoptosis (TWEAK) and its receptor Fn14 are involved in cell survival and cytokine production. The TWEAK/Fn14 pathway plays a role in the pathogenesis of spontaneous cutaneous lesions in the MRL/lpr lupus strain; however, the role of TWEAK/Fn14 in disease induced by ultraviolet B (UVB) irradiation has not been explored. MRL/lpr Fn14 knockout (KO) was compared to MRL/lpr Fn14 wild‐type (WT) mice following exposure to UVB. We found that irradiated MRL/lpr KO mice had significantly attenuated cutaneous disease when compared to their WT counterparts. There were also fewer infiltrating immune cells (CD3+, IBA‐1+ and NGAL+) in the UVB‐exposed skin of MRL/lpr Fn14KO mice, as compared to Fn14WT. Furthermore, we identified several macrophage‐derived proinflammatory chemokines with elevated expression in MRL/lpr mice after UV exposure. Depletion of macrophages, using a CSF‐1R inhibitor, was found to be protective against the development of skin lesions after UVB exposure. In combination with the phenotype of the MRL/lpr Fn14KO mice, these findings indicate a critical role for Fn14 and recruited macrophages in UVB‐triggered cutaneous lupus. Our data strongly suggest that TWEAK/Fn14 signalling is important in the pathogenesis of UVB‐induced cutaneous disease manifestations in the MRL/lpr model of lupus and further support this pathway as a possible target for therapeutic intervention.
Efficacy and safety of ustekinumab treatment in adults with moderate‐to‐severe atopic dermatitis
Authors: Khattri Saakshi , Brunner Patrick M. , Garcet Sandra , Finney Robert , Cohen Steven R. , Oliva Margeaux , Dutt Riana , Fuentes‐Duculan Judilyn , Zheng Xiuzhong , Li Xuan , Bonifacio Kathleen M. , Kunjravia Norma , Coats Israel , Cueto Inna , Gilleaudeau Patricia , Sullivan‐Whalen Mary , Suárez‐Fariñas Mayte , Krueger James G. , Guttman‐Yassky Emma 
Published: June 2016

AbstractAtopic dermatitis (AD) is the most common inflammatory skin disease, but treatment options for moderate‐to‐severe disease are limited. Ustekinumab is an IL‐12/IL‐23p40 antagonist that suppresses Th1, Th17 and Th22 activation, commonly used for psoriasis patients. We sought to assess efficacy and safety of ustekinumab in patients with moderate‐to‐severe AD. In this phase II, double‐blind, placebo‐controlled study, 33 patients with moderate‐to‐severe AD were randomly assigned to either ustekinumab (n=16) or placebo (n=17), with subsequent crossover at 16 weeks, and last dose at 32 weeks. Background therapy with mild topical steroids was allowed to promote retention. Study endpoints included clinical (SCORAD50) and biopsy‐based measures of tissue structure and inflammation, using protein and gene expression studies. The ustekinumab group achieved higher SCORAD50 responses at 12, 16 (the primary endpoint) and 20 weeks compared to placebo, but the difference between groups was not significant. The AD molecular profile/transcriptome showed early robust gene modulation, with sustained further improvements until 32 weeks in the initial ustekinumab group. Distinct and more robust modulation of Th1, Th17 and Th22 but also Th2‐related AD genes was seen after 4 weeks of ustekinumab treatment (i.e. MMP12, IL‐22, IL‐13, IFN‐γ, elafin/PI3, CXCL1 and CCL17; P<.05). Epidermal responses (K16, terminal differentiation) showed faster (4 weeks) and long‐term regulation (32 weeks) from baseline in the ustekinumab group. No severe adverse events were observed. Ustekinumab had clear clinical and molecular effects, but clinical outcomes might have been obscured by a profound “placebo” effect, most likely due to background topical glucocorticosteroids and possibly insufficient dosing for AD.
Followee recommendation in Twitter using fuzzy link prediction
Authors: Rodríguez Fernando M. , Torres Luis M. , Garza Sara E. 
Published: June 2016

AbstractIn social networking sites, it is useful to receive recommendations about whom to contact or follow. These recommendations not only allow to establish connections with people one might already know in real life but also with people or users that have similar interests or are potentially interesting. We propose an approach that tackles contact (followee) recommendation in Twitter by means of fuzzy logic. This fuzzy approach handles recommendation as a link prediction problem and uses three types of similarity between a pair of users: tweet similarity, followee id similarity, and followee tweet similarity. These similarities are calculated by extracting user profiles. These profiles are, in turn, obtained by considering Twitter as a heterogeneous information network. To test our approach, we crawled a repository of 6000 users and two million tweets, and we measured accuracy by comparing our results with the actual followee lists of the users. These results, which are also compared against the results given by state‐of‐the‐art methods, show a high accuracy. Other advantages of the fuzzy system include a self‐explanatory capability and the ability to produce a non‐binary friendship value.
Population and Economic Growth Under Different Growth Engines
Authors: Bucci Alberto , Raurich Xavier 
Published: June 2016

AbstractUsing a growth model with physical capital accumulation, human capital investment and horizontal R&D activity, this paper proposes an alternative channel through which an increase in the population growth rate may yield a non-uniform (i.e., a positive, negative, or neutral) impact on the long-run growth rate of per-capita GDP, as available empirical evidence seems mostly to suggest. The proposed mechanism relies on the nature of the process of economic growth (whether it is fully or semi-endogenous), and the peculiar engine(s) driving economic growth (human capital investment, R&D activity, or both). The model also explains why in the long term the association between population growth and productivity growth may ultimately be negative when R&D is an engine of economic growth.
Depressive symptoms in spouse caregivers of dementia patients: A longitudinal study in South Korea
Authors: Kim Woorim , Lee Tae‐Hoon , Shin Jaeyong , Park Eun‐Cheol 
Published: June 2016

AbstractAimTo investigate the association between spouse cognitive status and depressive symptoms in cohabiting spouses, and to further analyze how participation in social network‐enhancing activities interplays in the objected relationship.MethodsData from the Korean Longitudinal Study of Aging, 2006–2012, were used. A total of 2782 male and 2515 female married participants currently cohabiting with their partners were included in the baseline. The association between spouse cognitive status and depressive symptoms, measured using the Center for Epidemiological Studies Depression scale, was investigated through the generalized estimating equation model.ResultsWhen setting the participants living with spouses of normal cognitive function as reference, participants living with spouses having mild dementia (male β 0.7349, P ≤ 0.0001; female β 0.8042, P ≤ 0.0001), and moderate and severe dementia (male β 1.1504, P ≤ 0.0001; female β 1.2462, P ≤ 0.0006) showed higher depression scores in a dose–response relationship. Additionally, male and female subjects participating in social network facilitating activities had lower increases in depression scores than their non‐participating counterparts.ConclusionsSpouse cognitive impairment is associated with increasing depression scores in cohabiting caregivers. Individuals not participating in social network‐facilitating activities are more vulnerable to the negative mental health effects of spouse cognitive impairment. Hence, considering the increasing importance of late life depression and cognitive decline in aging societies, it is important to note the protective effects of social network and support in addressing the mental health of spouse caregivers. Geriatr Gerontol Int 2017; 17: 973–983.
Correlations between geriatric nutritional risk index and peripheral artery disease in elderly coronary artery disease patients
Authors: Kawamiya Toshiki , Suzuki Susumu , Ishii Hideki , Hirayama Kenshi , Harada Kazuhiro , Shibata Yohei , Tatami Yosuke , Harata Shingo , Kawashima Kazuhiro , Kunimura Ayako , Takayama Yohei , Shimbo Yusaku , Osugi Naohiro , Yamamoto Dai , Ota Tomoyuki , Kono Chikao , Murohara Toyoaki 
Published: June 2016

AimMalnutrition is associated with the development of atherosclerosis and an increased risk of cardiovascular mortality in elderly patients. The present study aimed to investigate the association between the Geriatric Nutritional Risk Index (GNRI), a simple nutritional assessment tool, and the prevalence of peripheral artery disease (PAD) in elderly coronary artery disease patients.MethodsWe evaluated 228 elderly coronary artery disease patients (mean age 74.0 ± 5.7 years). Ankle‐brachial index (ABI) measurements were routinely carried out to investigate the prevalence of lower extremity PAD. Patients showing ABI <0.9 were defined as having PAD.ResultsBased on our findings, 20.6% of the study patients had PAD. The median GNRI values were significantly lower in patients with PAD than those in patients without PAD (93.8 vs 100.0, P < 0.001). Even after multivariate adjustment, GNRI values were independently associated with PAD (odds ratio 0.94; 95% confidence interval 0.89–0.99; P = 0.024). Furthermore, patients with low GNRI and high C‐reactive protein levels had a 5.5‐fold higher risk of having PAD than those with high GNRI and low C‐reactive protein levels.ConclusionsGNRI values showed a strong relationship with PAD in elderly coronary artery disease patients. These data reinforce the utility of GNRI as a screening tool in clinical practice. Geriatr Gerontol Int 2017; 17: 1057–1062.
Appropriate Domain Size for Groundwater Flow Modeling with a Discrete Fracture Network Model
Authors: Ji Sung‐Hoon , Koh Yong‐Kwon 
Published: June 2016

AbstractWhen a discrete fracture network (DFN) is constructed from statistical conceptualization, uncertainty in simulating the hydraulic characteristics of a fracture network can arise due to the domain size. In this study, the appropriate domain size, where less significant uncertainty in the stochastic DFN model is expected, was suggested for the Korea Atomic Energy Research Institute Underground Research Tunnel (KURT) site. The stochastic DFN model for the site was established, and the appropriate domain size was determined with the density of the percolating cluster and the percolation probability using the stochastically generated DFNs for various domain sizes. The applicability of the appropriate domain size to our study site was evaluated by comparing the statistical properties of stochastically generated fractures of varying domain sizes and estimating the uncertainty in the equivalent permeability of the generated DFNs. Our results show that the uncertainty of the stochastic DFN model is acceptable when the modeling domain is larger than the determined appropriate domain size, and the appropriate domain size concept is applicable to our study site.
Differential modulation of Helicobacter pylori lipopolysaccharide‐mediated TLR2 signaling by individual Pellino proteins
Authors: Smith Sinéad M. , Freeley Michael , Moynagh Paul N. , Kelleher Dermot P. 
Published: June 2016

AbstractBackgroundEradication rates for current H. pylori therapies have fallen in recent years, in line with the emergence of antibiotic resistant infections. The development of therapeutic alternatives to antibiotics, such as immunomodulatory therapy and vaccines, requires a more lucid understanding of host–pathogen interactions, including the relationships between the organism and the innate immune response. Pellino proteins are emerging as key regulators of immune signaling, including the Toll‐like receptor pathways known to be regulated by H. pylori. The aim of this study was to characterize the role of Pellino proteins in the innate immune response to H. pylori lipopolysaccharide.Materials and MethodsGain‐of‐function and loss‐of‐function approaches were utilized to elucidate the role of individual Pellino proteins in the Toll‐like receptor 2‐mediated response to H. pylori LPS by monitoring NF‐ĸB activation and the induction of proinflammatory chemokines. Expression of Pellino family members was investigated in gastric epithelial cells and gastric tissue biopsy material.ResultsPellino1 and Pellino2 positively regulated Toll‐like receptor 2‐driven responses to H. pylori LPS, whereas Pellino3 exerted a negative modulatory role. Expression of Pellino1 was significantly higher than Pellino3 in gastric epithelial cells and gastric tissue. Furthermore, Pellino1 expression was further augmented in gastric epithelial cells in response to infection with H. pylori or stimulation with H. pylori LPS.ConclusionsThe combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll‐like receptor 2 engagement by H. pylori and/or its components, contributing to H. pylori‐associated pathogenesis by directing the incoming signal toward an NF‐kB‐mediated proinflammatory response.
Black urban consumers’ status consumption of clothing brands in the emerging South African market
Authors: Cronje Adèle , Jacobs Bertha , Retief Arda 
Published: June 2016

AbstractStatus concerns are noteworthy within a modern society as it is a key feature of individuals’ social reputation. Engaging in this form of thinking results in particular patterns of consumption within consumer groups. In South Africa, Black urban consumers have newfound spending power and social mobility. This study investigated motivators of Black urban consumers’ status consumption across different demographic variables (age, income and profession) in the South African (SA) emerging market. A survey research design was used to provide insights into the relationship of normative receptiveness (value expressive and utilitarian influences) and high self‐monitoring as status consumption motivators of clothing brand consumption. The sample consisted of 246 Black urban consumers between the ages of 24 and 36, residing in Gauteng, South Africa and currently working in professional positions. The results of the study indicated that when purchasing clothing Black urban consumers are motivated by factors related to status consumption.This study found no significant differences between age and gender variables in terms of status consumption. In terms of profession, all three motivational factors were significant. They proved to be very aware of the image that they communicate and how they are seen by others indicating that they are motivated especially by value expressiveness, utilitarian influences and high self‐monitoring aspects across various professions.
Fitting room or selling room? Millennial female consumers’ dressing room experiences
Authors: Vermaak Maryke , de Klerk Helena M. 
Published: June 2016

AbstractAs retail experiences have become more important to the modern consumer, the store environment has taken on greater significance. The store environment is especially of great significance to the millennial consumer. These consumers tend to spend more time in the fashion retail store, while their expenditure on fashion items increases on a yearly basis. The dressing room must be seen as the clothing retailer's selling room – the place where the retail environment plays an immense role with regard to a consumer's cognitions, emotions and purchasing behaviour. The purpose of this study was to explore and describe young millennial clothing consumers' Functional, aesthetic, emotional and symbolic dressing room experiences. A qualitative research strategy was followed. Two unstructured interviews were held with 15 participants. Participants had to take photos of retailers' dressing rooms before the second interview. A photo‐elicitation technique was employed during the second interview. Findings revealed that participants had specific expectations with regard to the functionality and aesthetics of the dressing room, as well as with regard to the symbolic messages and the emotions that they expected to experience. If the dressing room did not meet their expectations they got disappointed, experienced negative emotions and thoughts and the need to leave the dressing room. The behavioural response of avoidance strongly came to the forth. Findings of this research point to the importance of the dressing room as part of the retail experience and have implications for consumer specialists and retailers.