bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of thyrotrophin, thyroid hormones and thyroid antibodies on metabolic parameters in a euthyroid population with obesity
Authors: Temizkan Sule , Balaforlou Bilgken , Ozderya Aysenur , Avci Mehmet , Aydin Kadriye , Karaman Selin , Sargin Mehmet 
Published: May 2016

SummaryObjectiveTo investigate whether thyroid function in the euthyroid range and thyroid autoimmunity status would affect metabolic measures in individuals with obesity.DesignCross‐sectional.PatientsWe retrospectively evaluated 5300 consecutive obese (BMI ≥30 kg/m2) subjects attending the Obesity Outpatient Clinic. Subjects with overt or subclinical thyroid disease, diabetes mellitus, chronic disease or using any medication were excluded. After exclusion, 1275 euthyroid [TSH values >0·4 and <4·5 μIU/ml, free triiodothyronine (FT3), free thyroxine (FT4) in the normal reference range] obese subjects (aged 18–65 years) were eligible for the study.MeasurementsThe physical and biochemical records of the subjects at first admission to the obesity outpatient clinic were examined.ResultsEighty‐three per cent (n = 1063) of the study population were women. Antithyroid peroxidase (anti‐TPO) positivity was 14%, and antithyroglobulin (anti‐TG) positivity was 15%. TSH was 1·8 μIU/ml (1·3‒2·4) in antibody‐negative subjects and 2·1 μIU/ml (1·4‒2·9) in antibody‐positive subjects. Neither TSH nor thyroid antibody positivity was associated with insulin resistance (IR) and atherogenic dyslipidaemia after adjustment for confounders. FT3 was positively associated with IR (P < 0·001) and atherogenic dyslipidaemia (P = 0·03); however, this association lost its significance after adjustment for age, gender and BMI. FT4 was negatively associated with IR and this association remained even after adjustment for confounders (P < 0·001).ConclusionTSH and thyroid antibody positivity were not related with metabolic measures. Low‐normal FT4 had an inverse association with HOMA‐IR even after adjustment for confounders.
Accuracy of digital impressions of multiple dental implants: an in vitro study
Authors: Vandeweghe Stefan , Vervack Valentin , Dierens Melissa , De Bruyn Hugo 
Published: May 2016

AbstractIntroductionStudies demonstrated that the accuracy of intra‐oral scanners can be compared with conventional impressions for most indications. However, little is known about their applicability to take impressions of multiple implants.AimThe aim of this study was to evaluate the accuracy of four intra‐oral scanners when applied for implant impressions in the edentulous jaw.Material and methodsAn acrylic mandibular cast containing six external connection implants (region 36, 34, 32, 42, 44 and 46) with PEEK scanbodies was scanned using four intra‐oral scanners: the Lava C.O.S. and the 3M True Definition, Cerec Omnicam and 3Shape Trios. Each model was scanned 10 times with every intra‐oral scanner. As a reference, a highly accurate laboratory scanner (104i, Imetric, Courgenay, Switzerland) was used. The scans were imported into metrology software (Geomagic Qualify 12) for analyses. Accuracy was measured in terms of trueness (comparing test and reference) and precision (determining the deviation between different test scans). Mann–Whitney U‐test and Wilcoxon signed rank test were used to detect statistically significant differences in trueness and precision respectively.ResultsThe mean trueness was 0.112 mm for Lava COS, 0.035 mm for 3M TrueDef, 0.028 mm for Trios and 0.061 mm for Cerec Omnicam. There was no statistically significant difference between 3M TrueDef and Trios (P = 0.262). Cerec Omnicam was less accurate than 3M TrueDef (P = 0.013) and Trios (P = 0.005), but more accurate compared to Lava COS (P = 0.007). Lava COS was also less accurate compared to 3M TrueDef (P = 0.005) and Trios (P = 0.005).The mean precision was 0.066 mm for Lava COS, 0.030 mm for 3M TrueDef, 0.033 mm for Trios and 0.059 mm for Cerec Omnicam. There was no statistically significant difference between 3M TrueDef and Trios (P = 0.119). Cerec Omnicam was less accurate compared to 3M TrueDef (P < 0.001) and Trios (P < 0.001), but no difference was found with Lava COS (P = 0.169). Lava COS was also less accurate compared to 3M TrueDef (P < 0.001) and Trios (P < 0.001).ConclusionsBased on the findings of this in vitro study, the 3M True Definition and Trios scanner demonstrated the highest accuracy. The Lava COS was found not suitable for taking implant impressions for a cross‐arch bridge in the edentulous jaw.
Screening for adolescent suicidality in primary care: the bullying–insomnia–tobacco–stress test. A population‐based pilot study
Authors: Binder Philippe , Heintz Anne‐Laure , Servant Coralie , Roux Marie‐Thérèse , Robin Stéphane , Gicquel Ludovic , Ingrand Pierre 
Published: May 2016

AbstractAimAdolescents at risk for suicide often see their general practitioner solely for somatic or administrative reasons. A simple screening test given during a conversation would be of substantial help to send a signal and tackle the problem. We propose to update a screening test previously validated in France – the TSTS‐Cafard – because of significant changes in the lives of adolescents with the growth of the cyber world since 2000.MethodsThe design and setting was a cross‐sectional study involving 912 15‐year‐old adolescents in 90 French schools. They completed a questionnaire that included the TSTS‐Cafard and risk factors extracted from the Health Behaviour in School‐Aged Children survey. To improve the test, we selected questions drawn from the recent literature. Answers were analysed according to ‘suicidality’ = at least one suicide attempt in life or suicidal ideation often over the past 12 months.ResultsSuicidality rates were 9.6% for boys and 23.1% for girls. Although the TSTS‐Cafard test was generally effective, one question was no longer discriminating. A new test, entitled ‘BITS’, included only four questions on bullying, insomnia, tobacco and stress, with three levels of response and scores ranging from 0 to 8. Improvement was achieved without loss of performance. Using a cut‐off score of 3, we achieved 78% accuracy (area under the curve), 75% sensitivity and 70% specificity.ConclusionThe BITS test could allow the question of suicide risk to be addressed during a routine check‐up in primary care but the results need to be validated with 13 to 18‐year olds.
Factors associated with health‐related decision‐making in older adults from Southern Brazil
Authors: Morsch Patricia , Mirandola Andrea Ribeiro , Caberlon Iride Cristofoli , Bós Ângelo José Gonçalves 
Published: May 2016

AimTo analyze older adults’ health‐related decision‐making profile.MethodsSecondary analysis of a population‐based study with 6945 older‐adults (aged ≥60 years) in Southern Brazil. Multiple logistic regressions were calculated to describe the odds of deciding alone or asking for advice, compared with the chance of letting someone else decide about health‐related issues. Associated variables were age, sex, marital status, education level, number of chronic morbidities, having children and quality of life.ResultsThe odds of asking for advice instead of letting others decide were significantly higher in the younger group and those with better levels of quality of life, independent of other variables. The chance of asking for advice was lower for unmarried (62%), widowed (76%) and those with children (50%). The chance of men deciding for themselves about their health instead of letting others decide was 47% higher compared with women (P = 0.0002), but 45% lower in the older group (P < 0.0001). Participants who where unmarried and childless, and individuals with better levels of quality of life were more likely to decide alone instead of letting others decide (P < 0.05).ConclusionsDecision‐making is fundamental for older adults’ good quality of life. Aging makes older adults more vulnerable to dependence; however, it does not necessarily mean that they lose or decrease their ability to make decisions regarding their own health and desires. Geriatr Gerontol Int 2017; 17: 798‐803.
Stent graft repair of iatrogenic femoral arteriovenous fistula with acute bleeding after hemodialysis catheter insertion
Authors: Lee Chih‐Hsien 
Published: May 2016

AbstractAn arteriovenous fistula (AVF) is an abnormal connection between an artery and a vein. Double‐lumen catheters are widely used for gaining temporary access in patients requiring acute hemodialysis (HD). Several complications are associated with the insertion of these catheters, including bleeding, infection, arterial injuries, and deep venous thrombosis. An iatrogenic AVF is a rare and severe complication following catheterization for temporary HD. Here, we report the case of a patient who developed an iatrogenic AVF following catheterization for acute HD resulting in acute bleeding. A 61‐year‐old male experienced acute renal failure with pulmonary edema. A 12 French (Fr) dialysis catheter was inserted into the right femoral vein for emergent HD. Active pulsation bleeding was observed around the catheter at the right inguinal area after first HD. A thrill was felt at the superficial femoral artery after the repair of its anterior side. Angiography revealed iatrogenic AVF, which was successfully treated with stent graft repair.
Safety and efficacy of faldaprevir in combination with pegylated interferon α‐2b and ribavirin in Japanese patients with genotype‐1 chronic hepatitis C virus infection
Authors: Nishiguchi Shuhei , Urano Yasuhisa , Suzaki Keiko , Taniguchi Atsushi , Scherer Joseph , Berger Kristi L. , Quinson Anne‐Marie , Stern Jerry O. , Omata Masao 
Published: May 2016

AimWe evaluated the safety and efficacy of the hepatitis C virus (HCV) NS3/4A A protease inhibitor faldaprevir plus pegylated interferon α‐2b and ribavirin (PegIFNα‐2b/RBV) in Japanese patients with HCV genotype‐1 infection.MethodsTreatment‐naïve patients were randomized (1:1) to faldaprevir 120 mg q.d. for 12 or 24 weeks (response‐guided therapy [RGT], n = 44), or faldaprevir 240 mg q.d. for 12 weeks (n = 43), each combined with PegIFNα‐2b/RBV for 24 or 48 weeks (RGT). Response‐guided therapy was based on early treatment success (HCV RNA <25 IU/mL at week 4 and <25 IU/mL undetected at week 8). Treatment‐experienced patients received 240 mg q.d. for 24 weeks, plus PegIFNα‐2b/RBV RGT (24 or 48 weeks, prior relapsers, n = 29) or PegIFNα‐2b/RBV (48 weeks, 5 prior partial responders/breakthroughs, 10 prior null responders). The primary objective was safety; sustained virologic response 12 weeks post‐treatment (SVR12) was a secondary end‐point.ResultsAll except one patient experienced drug‐related adverse events. Adverse events led to faldaprevir discontinuation in 1 (2%), 13 (20%), and 3 (6.8%) patients on faldaprevir 120 mg, faldaprevir 240 mg 12 weeks, and faldaprevir 240 mg 24 weeks, respectively. The SVR12 rates were: 86% with faldaprevir 120 mg and 74% with faldaprevir 240 mg among treatment‐naïve patients; and 86%, 60%, and 40% among prior relapsers, partial responders/breakthroughs, and null responders, respectively.ConclusionsIn treatment‐naïve Japanese patients, faldaprevir 120 mg q.d. plus PegIFNα‐2b/RBV was better tolerated than faldaprevir 240 mg q.d. plus PegIFNα‐2b/RBV, with at least comparable efficacy. In treatment‐experienced patients, most prior relapsers achieved SVR12 with 24 weeks of faldaprevir 240 mg q.d. plus PegIFNα‐2b/RBV. Clinicaltrials.gov NCT01579474.
The Conditions of Movement: a Discussion of Academic Mobility between Two Early Career Scholars
Authors: Gopaul Bryan , Pifer Meghan J. 
Published: May 2016

AbstractAcademic mobility is an increasingly crucial topic to the current and future dynamics of doctoral study and the professoriate. Much of the research has focused on US, UK and European contexts. This research explores academic mobility and the manifold issues that arise between the jurisdictions of Canada and the US, in ways that parallel and diversify previous research based on various understandings of mobility. The qualitative perspective is grounded in a reflective narrative approach that enables exploration of powerful themes. The findings indicate that there are costs, tensions and benefits to academic mobility that serve to emphasise specific personal and professional elements to the pursuit of academic life that need explicit articulation. These findings encourage additional scholarly and practical attention to the changing nature of doctoral study and of academic work and life across jurisdictions.
BRAFV600E and NRASQ61L/Q61R mutation analysis in metastatic melanoma using immunohistochemistry: a study of 754 cases highlighting potential pitfalls and guidelines for interpretation and reporting
Authors: Kakavand Hojabr , Walker Emily , Lum Trina , Wilmott James S , Selinger Christina I , Smith Elizabeth , Saw Robyn P M , Yu Bing , Cooper Wendy A , Long Georgina V , O'Toole Sandra A , Scolyer Richard A 
Published: May 2016

Background and aimsBRAF or NRAS mutations occur in approximately 60% of cutaneous melanomas, and the identification of such mutations underpins the appropriate selection of patients who may benefit from BRAF and MEK inhibitor targeted therapies. The utility of immunohistochemistry (IHC) to detect NRASQ61L mutations is currently unknown. This study sought to assess the sensitivity and specificity of anti‐BRAFV600E (VE1), anti‐NRASQ61R (SP174) and anti‐NRASQ61L (26193) antibodies for mutation detection in a large series of cases.Methods and resultsMutation status was determined using the OncoCarta assay in 754 cutaneous melanomas. IHC with the anti‐BRAFV600E antibody was performed in all cases, and the anti‐NRASQ61R and anti‐NRASQ61L antibodies were assessed in a subset of 302 samples utilizing tissue microarrays. The staining with the anti‐BRAFV600E and anti‐NRASQ61R antibodies was diffuse, homogeneous and cytoplasmic. The anti‐NRASQ61L antibody displayed variable intensity staining, ranging from weak to strong in NRASQ61L mutant tumours. The sensitivity and specificity for anti‐BRAFV600E was 100 and 99.3%, anti‐NRASQ61R was 100 and 100% and anti‐NRASQ61L was 82.6 and 96.2%, respectively.ConclusionsThe use of IHC is a fast, efficient and cost‐effective method to identify single specific mutations in melanoma patients. BRAFV600E and NRASQ61R antibodies have high sensitivity and specificity; however, the NRASQ61L antibody appears less sensitive. IHC can help to facilitate the timely, appropriate selection and treatment of metastatic melanoma patients with targeted therapies. Detection of melanoma‐associated mutations by IHC may also provide evidence for a diagnosis of melanoma in metastatic undifferentiated neoplasms lacking expression of melanoma antigens.
MODERNITY AND THE PROBLEM OF ITS CHRISTIAN PAST: THE GEISTESGESCHICHTEN OF BLUMENBERG, BERGER, AND GAUCHET
Authors: GRIFFIOEN SJOERD 
Published: May 2016

ABSTRACTRecent years have seen the rise of “post‐secularism,” a new perspective that criticizes the dominant secularization narrative according to which “modernity” and “religion” are fundamentally antagonistic concepts. Jürgen Habermas, Charles Taylor, and Gianni Vattimo are the most prominent defenders of such a post‐secularist account. But though post‐secularism presents itself as a necessary rectification of the secularization story, it has not been able to come up with a credible and generally accepted alternative account. In this article I will explain why, arguing that the use of “essentially contested concepts” such as “Christianity” and “modernity” rest on normative standpoints of the narrators that are incompatible with one another. To show this I will analyze the position of three older voices in the debate, namely those of Hans Blumenberg, Peter Berger, and Marcel Gauchet. These authors seem to agree in understanding the modern disenchanted worldview in relation to Christian transcendence, but I will show that beneath their similar narratives lie incompatible normative beliefs on which their use of the concepts of “Christianity” and “modernity” is founded. After having laid bare the roots of the contemporary debate by exploring these three fundamental positions, I will finally argue that we should not take their accounts as objective, historical descriptions but as what Richard Rorty has called “Geistesgeschichte“: a speculative history that is aimed at conveying a moral, in which essentially contested concepts play a constitutive role. Each author draws his own moral, and consequently each author will construct his own corresponding history. This lesson can then be applied to the contemporary debate on secularization. The value of the debate does not lie in its historical claims but in the visions of the protagonists; at the end of this article I will explain how we can capitalize on this value.
ARRIVAL OF COURTLY LOVE: MOVING IN THE EMOTIONAL SPACE
Authors: Bonneuil Noël 
Published: May 2016

ABSTRACTCourtly love appeared in twelfth‐century Europe as a dissent from the emotional regime established by the Gregorian Reform, by setting the lady, instead of God, as the object of worship. From a game‐theory perspective, courtly love and hedonism correspond to Nash equilibria, in contrast to Christian marriage, whose stability is threatened by sex‐as‐appetite on one side and devotion to God on the other, and whose maintenance depends on moral control. The Church developed fear and shame, which are counter‐emotions to desire‐as‐appetite. Courtly love restored the thrill of forbidden adventure. It also shared traits common to innovations in the natural world: it added complexity (by increasing costs, emphasizing courtship, self‐restraint, and extremes of suffering); it was made possible by the plasticity of mating relationships; it introduced a small disorder in the ordered regime of Christian marriage; it demanded an adaptive effort, requiring the man to face ever more perilous trials and the woman to appear ever more attractive. Though obtained as a small deviation from the existing emotional regime, it had thoroughgoing and long‐lasting consequences for social control and for the political power of the Church. It also deeply modified the dynamic of longing in ego's representation. By taking the temporal form of a capture, it contrasts with twelfth‐century Bengal, where love was characterized by maintenance in an indefinitely repeating worship, by the absence of a here‐now versus target‐later dualism. It also contrasts with eleventh‐century Heian Japan, where love was intermingled with the melancholy of an impossible return, which is the antithesis of the concept of capture.
Recurrence rates of periocular basal cell carcinoma following Mohs micrographic surgery: a retrospective study
Authors: Sin Chun W. , Barua Ankur , Cook Anne 
Published: May 2016

AbstractBackgroundThe incidence of basal cell carcinoma (BCC) has increased during the previous decade. Mohs micrographic surgery (MMS) is the gold standard technique for BCCs. The aim of this study was to investigate the recurrence rate of periocular BCCs following MMS in a regional Mohs treatment facility in the United Kingdom.Materials and methodsThe study comprised a retrospective case note review of 480 patients who underwent MMS from 2001 to 2006 for periocular BCC. Patients were identified via hospital coding databases. Medical records were reviewed, and the parameters collected include age, gender, previous BCCs and treatment modality, postoperative complications and subsequent management, site, size of lesion, histological subtype, and recurrence following MMS.ResultsThree hundred and ninety of the 480 patients identified were included. The remaining patients had died before the 5‐year analysis (65), were lost to follow‐up (20), or were identified as having Gorlin's syndrome (5). The majority of BCCs were 6–10 mm (42%) and nodular (45%). Six recurrences were identified (1.5%), including one (0.3%) primary BCC and five (6.5%) recurrent BCCs at the time of the MMS. The mean follow‐up was 30 months (range 1–120 months).ConclusionFor BCC in the periocular region, MMS should be the treatment of choice for both primary and recurrent periocular BCCs. The increased recurrence rate, demonstrated by recurrent BCCs, highlights the need for a comprehensive follow‐up.
Chia (Salvia hispanica L.) as fat replacer in sweet pan breads
Authors: Zettel Viktoria , Hitzmann Bernd 
Published: May 2016

SummaryThe effects of gel from ground chia (Salvia hispanica L.) were studied as a fat replacer in sweet pan breads. This substitution was addressed to reduce the total amount of fat in the product and to improve the nutritional value of the products regarding the fatty acid composition. The effects on the baking results were determined by assessing common baking evaluations and texture analysis after 2 and 48 h. The doughs were characterised with rheometer and rheofermentometer measurements. Rheometer measurements revealed that the replacement resulted in softer doughs with decreasing values for storage and loss moduli with increasing chia content. The yeast activity was increased with incorporated chia gel compared to the control. The best results for the baking experiments were obtained with 25% fat replacement through ground chia gel. Here, the highest volume yield with the softest crumb even after 48 h was achieved.
TSLP, IL‐31, IL‐33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis
Authors: Nygaard U. , Hvid M. , Johansen C. , Buchner M. , Fölster‐Holst R. , Deleuran M. , Vestergaard C. 
Published: May 2016

AbstractBackgroundRecent years have seen growing interest in identifying new biomarkers in atopic dermatitis (AD) that could serve as indicators of disease severity and predictors of treatment response.ObjectivesWe compared serum levels of thymic stromal lymphopoietin (TSLP), interleukin(IL)‐31, IL‐33 and soluble(s)ST2 in AD patients and healthy controls, investigated the possible correlation with disease severity, investigated if other atopic comorbidities could play a role, and assessed their potential as biomarkers in AD.MethodsUsing standard enzyme‐linked immunosorbent assay techniques, we measured target serum levels in 71 adults and 61 children with AD, and 31 adult controls. We characterized our cohort by disease severity, radioallergosorbent test status concerning both dietary and inhalant allergens, and anamnestic reports of food allergy, concomitant allergic asthma and/or allergic rhinitis.ResultsSerum levels of TSLP, IL‐31 and IL‐33, but not sST2, were significantly elevated in AD patients compared with controls. In AD patients, both IL‐31 and IL‐33 serum levels were higher in children than in adults, while the opposite was the case for sST2. We observed no correlation between disease severity and any of the investigated targets. While serum TSLP levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL‐31, IL‐33 and sST2 were affected to a small extent. We found a positive correlation between TSLP, IL‐31 and IL‐33, and an inverse relationship between IL‐33 and sST2.ConclusionsThe studied targets hold little potential as indicators of disease severity. The serum values of our targets show robustness against atopic comorbidities, allergies and changes in disease severity. This robustness strengthens their potential use in biomarker‐based stratification and could be instrumental in identifying subgroups and predicting the possible benefit of therapeutic and prevention approaches.