bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left atrial appendage closure: A single center experience and comparison of two contemporary devices
Authors: Figini Filippo , Mazzone Patrizio , Regazzoli Damiano , Porata Giulia , Ruparelia Neil , Giannini Francesco , Stella Stefano , Ancona Francesco , Agricola Eustachio , Sora Nicoleta , Marzi Alessandra , Aurelio Andrea , Trevisi Nicola , Della Bella Paolo , Colombo Antonio , Montorfano Matteo 
Published: August 2016

ObjectivesTo compare indications and clinical outcomes of two contemporary left atrial appendage (LAA) percutaneous closure systems in a “real‐world” population.BackgroundPercutaneous LAA occlusion is an emerging therapeutic option for stroke prevention in atrial fibrillation. Some questions however remain unanswered, such as the applicability of results of randomized trials to current clinical practice. Moreover, currently available devices have never been directly compared.MethodsWe retrospectively analyzed consecutive patients who underwent LAA closure at San Raffaele Hospital, Milan, Italy between 2009 and 2015. Clinical indications and device selection were left to operators' decision; routine clinical and transesophageal echocardiography (TEE) follow‐up was performed.ResultsOne‐hundred and sixty‐five patients were included in the study, of which 99 were treated with the Amplatzer Cardiac Plug (ACP) and 66 with the Watchman system. During the follow‐up period (median 15 months, interquartile range 6–26 months) five patients died. The incidence of ischemic events was low, with one patient suffering a transient ischemic attack and no episodes recorded of definitive strokes. Twenty‐six leaks ≥1 mm were detected (23%); leaks were less common with the ACP and with periprocedural three‐dimensional TEE evaluation, but were not found to correlate with clinical events. Clinical outcomes were comparable between the two devices.ConclusionsOur data show excellent safety and efficacy of LAA closure, irrespectively of the device utilized, in a population at high ischemic and hemorrhagic risk. The use of ACP and 3D‐TEE minimized the incidence of residual leaks; however, the clinical relevance of small peri‐device flow warrants further investigation. © 2016 Wiley Periodicals, Inc.
Intravascular ultrasound‐derived morphological predictors of myocardial ischemia assessed by stress myocardial perfusion computed tomography
Authors: Kang Soo‐Jin , Yang Dong Hyun , Koo Hyun Jung , Yun Sung‐Cheol , Lee June‐Goo , Kang Joon‐Won , Lim Tae‐Hwan , Mintz Gary S. , Park Seong‐Wook , Kim Young‐Hak 
Published: August 2016

BackgroundAlthough ischemia‐guided revascularization improves clinical outcomes, morphological determinants of clinically relevant myocardial ischemia have not been studied. To identify intravascular ultrasound (IVUS)‐derived anatomical parameters for predicting myocardial perfusion defect and its extent.MethodsA total of 103 patients (88 stable and 15 unstable angina) with 153 lesions (angiographic diameter stenosis of 30–80%) underwent stress myocardial perfusion computed tomography (CT) and IVUS pre‐procedure. The volume of CT perfusion defect and %CT perfusion defect in the target vessel territories were measured.ResultsThe CT perfusion defect was seen in 76 (50%) lesions. The independent determinants for the presence of CT perfusion defect were IVUS‐minimal lumen area (MLA) (adjusted OR = 0.56, 95% CI = 0.38–0.82), plaque burden (adjusted OR = 1.07, 95% CI = 1.02–1.11) and involvement of left main or left anterior descending artery (adjusted OR = 4.13, 95% CI = 1.75–9.78, all P < 0.05). The CT perfusion defect was predicted by IVUS‐MLA <2.28mm2 (sensitivity 74%, specificity 82%) and plaque burden >77% (sensitivity 79%, specificity 78%) as thresholds. The independent determinants for the volume of CT perfusion defect were the involvement of left main or left anterior descending artery (β = 16.43, standard errors = 4.387, P = 0.020) and a greater plaque burden (β = 0.56, standard errors = 0.163, P = 0.026).ConclusionsIVUS‐derived morphological parameters were useful to predict the presence of CT perfusion defect and the size of myocardial ischemia that were primarily determined by lesion severity and subtended myocardial territory. © 2016 Wiley Periodicals, Inc.
Defining the common femoral artery: Insights from the femoral arterial access with ultrasound trial
Authors: Seto Arnold H. , Tyler Jeffrey , Suh William M. , Harrison Alexander T. , Vera Jesus A. , Zacharias Soni J. , Daly Timothy S. , Sparling Jeffrey M. , Patel Pranav M. , Kern Morton J. , Abu‐Fadel Mazen 
Published: August 2016

ObjectiveWe sought to establish the typical location of the common femoral artery (CFA) bifurcation, the origin and most inferior reflection of the inferior epigastric artery (IEA) relative to the femoral head (FH) and whether patient demographics predicted anatomical variations.BackgroundIn the absence of ultrasound guidance or prior imaging, the precise location of the CFA bifurcation and IEA can only be determined following access site angiography. Fluoroscopic landmarks are commonly used to estimate the location of the CFA bifurcation, but the position of the IEA is less well characterized.MethodsProspectively collected data on 989 patients with femoral angiography in the FAUST trial were analyzed. The level of CFA bifurcation and the origin and most inferior reflection of the IEA were classified by angiography. Logistic regression was used to explore whether baseline demographics were associated with anatomic variations.ResultsThe CFA bifurcation occurs below the middle 1/3rd of the femoral head in 95% of patients, and no patient factors are predictive of a high bifurcation. The IEA origin has a more variable anatomically pattern, with high BSA, male gender, and white race associated with a low IEA origin.ConclusionOperators should attempt to access the CFA at the level of the middle 1/3rd of the FH to maximize the chance of CFA cannulation. However, this location carries an 11% risk of being at or above the IEA origin. Baseline demographics were of limited utility for predicting anatomic variants of the CFA bifurcation and the course of the IEA. © 2016 Wiley Periodicals, Inc.
First prospective multicenter experience with the 7 French Glidesheath slender for complex transradial coronary interventions
Authors: Aminian Adel , Iglesias Juan F. , Van Mieghem Carlos , Zuffi Andrea , Ferrara Angela , Manih Roukos , Dolatabadi Dariouch , Lalmand Jacques , Saito Shigeru 
Published: August 2016

PurposeTo assess the feasibility and safety of the 7 French (Fr) Glidesheath Slender for complex transradial (TR) percutaneous coronary interventions (PCI).BackgroundThe TR approach is increasingly used worldwide for coronary and peripheral vascular interventions. However, the small size of the radial artery remains an important limitation for the use of large‐bore guiding catheters (>6 Fr), restricting thereby the treatment of highly complex lesions through the TR approach. The 7 Fr Glidesheath slender (Terumo, Tokyo, Japan) is a new dedicated radial sheath with a thinner wall and hydrophilic coating. It combines an inner diameter compatible with any 7 Fr guiding catheter and an outer diameter smaller than current 7 Fr sheaths.MethodsProspective multicenter registry of complex TR PCI cases using the 7 Fr Glidesheath Slender to determine the procedural success, rates of vascular complications, radial spasm, and radial artery occlusion (RAO).ResultsA total of 60 patients were included. Procedural success was 97% with only one access‐site crossover. The use of a 7 Fr guiding catheter was indicated for the treatment of highly complex coronary lesions including distal left main (LM) disease (n = 20), complex non‐LM bifurcation lesions (n = 16), chronic total occlusion (n = 15), and severely calcified vessels requiring rotational atherectomy (n = 10). There were three vascular access‐site complications (4.7%) including two moderate (type II) local hematoma and one uncomplicated guiding catheter‐induced brachial artery dissection. None of the patients experienced major bleeding. The occurrence of radial spasm was reported in seven patients (11%). Doppler ultrasound imaging of the radial artery at 1 month was available in 62 of 64 radial access with three cases of RAO (4.8%).ConclusionsUse of the 7 Fr Glidesheath slender for complex coronary interventions is feasible and associated with a high rate of procedural success and a low rate of vascular complications. These favorable results need be confirmed in larger multicenter studies. © 2016 Wiley Periodicals, Inc.
Should endovascular approach be the first line of treatment for retroperitoneal bleeding with hemodynamic shock following percutaneous intervention? A case series
Authors: Seropian Ignacio M. , Angiolillo Dominick J. , Zenni Martin M. , Bass Theodore A. , Guzman Luis A. 
Published: August 2016

ObjectivesTo report a series of consecutive patients that developed retroperitoneal hemorrhage (RPH) and persistent hypotension treated with endovascular approach.BackgroundRPH is a rare complication of percutaneous cardiovascular interventions associated with high morbidity and mortality. The standard approach to treat this complication has been a conservative management for stable patients, and urgent vascular surgery for those with persistent hypovolemic shock. Percutaneous endovascular treatment has evolved as an alternative treatment option.MethodsWe implemented a management algorithm for patients with suspected RPH and persistent hypotension which embraced systematic use of emergency endovascular evaluation and treatment following clinical assessment without the use of non‐invasive diagnostic testing. We report a series of 8 consecutive patients that developed RPH with persistent hypotension.ResultsSuccessful percutaneous treatment was achieved in all cases with the use of a covered stent. No patient required vascular surgery. The average blood transfusion was 3.4 ± 2.7 units per patient. There were no deaths; one patient experienced acute stent thrombosis that was successfully treated via endovascular approach. At 1‐year follow‐up, no further events were reported.ConclusionThe incorporation of a standardized protocol using only clinical evaluation followed by emergency percutaneous approach without delays attributed to non‐invasive diagnostic work‐up showed to be feasible and associated with favorable outcomes. © 2016 Wiley Periodicals, Inc.
The impact of delirium on healthcare utilization and survival after transcatheter aortic valve replacement
Authors: Huded Chetan P. , Huded Jill M. , Sweis Ranya N. , Ricciardi Mark J. , Malaisrie S. Chris , Davidson Charles J. , Flaherty James D. 
Published: August 2016

ObjectivesWe assessed whether post‐operative delirium is associated with healthcare utilization and overall survival after trans‐catheter aortic valve replacement.BackgroundDelirium, a common syndrome among hospitalized older adults, is associated with increased morbidity and mortality.MethodsWe reviewed 294 transcatheter aortic valve replacement cases between June 2008 and February 2015 at a tertiary care academic medical center. Post‐operative delirium was identified by confusion assessment method screening and clinician diagnosis.ResultsDelirium was identified in 61 patients (21%). Non‐femoral access for trans‐catheter aortic valve replacement was more common in delirious patients than in non‐delirious patients (41% vs. 27%, P = 0.04). Delirious patients had diminished overall survival after trans‐catheter aortic valve replacement compared to non‐delirious patients (1‐year survival 59% vs. 84%, log‐rank P = 0.002). After adjusting for age, Society of Thoracic Surgeons predicted 30‐day mortality, and access type; delirium remained independently associated with diminished overall survival (hazard ratio 2.01, 95% confidence interval 1.21–3.33, P = 0.007). The delirium group had longer mean hospital stay (13.3 ± 9.5 days vs. 6.7 ± 3.8 days, P < 0.001) and a higher rate of discharge to a rehabilitation facility (61% vs. 27%, P < 0.001), but there was no difference in 30‐day hospital re‐admission rates or 30‐day mortality based on delirium status.ConclusionsDelirium occurs in one out of five patients after trans‐catheter aortic valve replacement and is associated with diminished survival and increased healthcare utilization. Further studies are needed to clarify whether strategies aimed at reducing delirium after trans‐catheter aortic valve replacement may improve outcomes in this high‐risk subset. © 2016 Wiley Periodicals, Inc.
Anatomical and functional assessment of Tryton bifurcation stent before and after final kissing balloon dilatation: Evaluations by three‐dimensional coronary angiography, optical coherence tomography imaging and fractional flow reserve
Authors: Pyxaras Stylianos A. , Toth Gabor G. , Di Gioia Giuseppe , Ughi Giovanni J. , Tu Shengxian , Rusinaru Dan , Adriaenssens Tom , Reiber Johan H.C. , Leon Martin B. , Bax Jeroen J. , Wijns William 
Published: August 2016

ObjectivesTo assess the anatomical and functional impact of final kissing balloon inflation (FKBI) after implantation of a dedicated bifurcation stent system.BackgroundCurrent evidence suggests clinical benefit of FKBI in patients undergoing bifurcation dilatation using the Tryton side branch stent (Tryton‐SBS). We hypothesized that FKBI improves anatomical reconstruction and functional results of bifurcation treated by Tryton‐SBS.MethodsAn unselected group of patients with complex bifurcation coronary lesions undergoing percutaneous coronary intervention (PCI) with Tryton‐SBS underwent paired anatomical assessment with two‐ and three‐dimensional quantitative coronary analysis (2D‐ and 3D‐QCA), and optical coherence tomography (OCT), including 3D reconstruction before and after FKBI. Functional assessment by fractional flow reserve (FFR) was performed in the main branch (MB) and side branch (SB) before and after FKBI.ResultsPaired pre‐ and post‐FKBI data were obtained in 10 patients. By OCT imaging, FKBI increased both the SB ostial area (4.93 ± 2.81 vs. 7.43 ± 2.87 mm2, P < 0.001) and the SB maximum diameter (3.12 ± 0.98 vs. 3.82 ± 1.10 mm, P = 0.003). These findings were associated with a significant increase in FFR in the SB (0.90 ± 0.05 vs. 0.94 ± 0.03; P = 0.011), with no significant change in the MB (0.91 ± 0.05 vs. 0.92 ± 0.04; P = 0.470).ConclusionsIn patients with complex bifurcation stenosis undergoing PCI with a dedicated bifurcation system, FKBI is associated with improved anatomical and functional results at the SB level, without compromising the result at the MB. © 2016 Wiley Periodicals, Inc.
ORBIT II sub‐analysis: Impact of impaired renal function following treatment of severely calcified coronary lesions with the Orbital Atherectomy System
Authors: Lee Michael S. , Lee Arthur C. , Shlofmitz Richard A. , Martinsen Brad J. , Hargus Nick J. , Elder Mahir D. , Généreux Philippe , Chambers Jeffrey W. 
Published: August 2016

ObjectivesTo investigate the safety and efficacy of the coronary Orbital Atherectomy System (OAS) to prepare severely calcified lesions for stent deployment in patients grouped by renal function.BackgroundPercutaneous coronary intervention (PCI) of severely calcified lesions is associated with increased rates of major adverse cardiac events (MACE), including death, myocardial infarction (MI), and target vessel revascularization (TVR) compared with PCI of non‐calcified vessels. Patients with chronic kidney disease (CKD) are at increased risk for MACE after PCI. The impact of CKD on coronary orbital atherectomy treatment has not been well characterized.MethodsORBIT II was a prospective, multicenter trial in the U.S., which enrolled 443 patients with severely calcified coronary lesions. The MACE rate was defined as a composite of cardiac death, MI, and target vessel revascularization.ResultsOf the 441 patients enrolled with known estimated glomerular filtration rate (eGFR) values at baseline, 333 (75.5%) patients had eGFR < 90 ml/min/1.73 m2 and 108 patients had eGFR ≥ 90 ml/min/1.73 m2. The mean eGFR at baseline in the eGFR < 90 ml/min/1.73 m2 and eGFR ≥ 90 ml/min/1.73 m2 groups was 65.0 ± 0.9 ml/min/1.73 m2 and 109.1 ± 2.0 ml/min/1.73 m2, respectively. Freedom from MACE was lower in the eGFR < 90 ml/min/1.73 m2 group at 30 days (87.4% vs. 96.3%, P = 0.02) and 1‐year (80.6% vs. 90.7%, P = 0.02).ConclusionsPatients with renal impairment had a higher MACE rate through one year follow‐up due to a higher rate of periprocedural MI. Interestingly, the rates of cardiac death and revascularization through 1‐year were similar in patients with eGFR < 90 ml/min/1.73 m2 and eGFR ≥ 90 ml/min/1.73 m2. Future studies are needed to identify the ideal revascularization strategy for patients with renal impairment and severely calcified coronary lesions. © 2016 Wiley Periodicals, Inc.
Heterogeneous CPU+GPU approaches for mesh refinement over Lattice‐Boltzmann simulations
Authors: Valero‐Lara Pedro , Jansson Johan 
Published: August 2016

SummaryThe use of mesh refinement in CFD is an efficient and widely used methodology to minimize the computational cost by solving those regions of high geometrical complexity with a finer grid. In this work, the author focuses on studying two methods, one based on Multi‐Domain and one based on Irregular meshing, to deal with mesh refinement over LBM simulations. The numerical formulation is presented in detail. It is proposed two approaches, homogeneous GPU and heterogeneous CPU+GPU, on each of the refinement methods. Obviously, the use of the two architectures, CPU and GPU, to compute the same problem involves more important challenges with respect to the homogeneous counterpart. These challenges and the strategies to deal with them are described in detail into the present work. We pay a particular attention to the differences among both methodologies/implementations in terms of programmability, memory management, and performance. The size of the refined sub‐domain has important consequences over both methodologies; however, the influence on Multi‐Domain approach is much higher. For instance, when dealing with a big refined sub‐domain, theMulti‐Domainapproach achieves an important fall in performance with respect to other cases, where the size of the refined sub‐domain is smaller. Otherwise, using theIrregularapproach, there is no such a dramatic fall in performance when increasing the size of the refined sub‐domain. Copyright © 2016 John Wiley & Sons, Ltd.
A novel method based on MapReduce to extract auxiliary information for GNSS receivers
Authors: Li Dengao , Wu Gang , Zhao Jumin , Niu Wenhui , Li Shuai 
Published: August 2016

SummaryIn order to improve the positioning and navigation performance of Global Navigation Satellite System (GNSS) receivers, a novel method to extract auxiliary information for GNSS receiver is proposed in this paper, which obtains the area GNSS auxiliary information (AGAI) with enough credibility and area attribute. Firstly, a mass of historical GNSS intermediate frequency data is divided into blocks to be acquired and tracked parallel getting massive pseudorange and navigation message (MPD). Then, the massive MPD are weighted and fused parallel by an appropriate weight matrix, which is determined by a priori weighting based on altitude angle and posterior weighting based on M‐residuals variable components estimation. Lastly, the fused information is corresponded to the corresponding location coordinate, completing the parallel extraction of AGAI. The method implemented by parallel programming models MapReduce of Hadoop to guarantee a high efficiency. Experimental results show that the positioning and velocity error of GNSS receivers are reduced by 18.24% and 20.48% using AGAI instead of traditional auxiliary information, and the execution time of the method using MapReduce is reduced by 46.72%, so the proposed method is reliable and effective. Copyright © 2016 John Wiley & Sons, Ltd.
Pre‐image sample algorithm with irregular Gaussian distribution and construction of identity‐based signature
Authors: Yan Jianhua , Wang Licheng , Li Jing , Li Muzi , Yang Yixan , Yao Wenbin 
Published: August 2016

SummaryLattice has become an attractive cryptographic tool due to its potential resistance to quantum attacks, worst‐case hardness, simple computation kind, and flexibility. The pre‐image sample algorithm is the most fundamental algorithm in lattice‐based cryptography for its comprehensive applications in various primitives. Currently,
due to Micciancio and Peikert (MP) sample algorithm is the most efficient pre‐image sample algorithm. However, this algorithm also needs massive computations. On the one hand, it expenses the cube of the lattice dimension multiplications over reals to set matrices as Gaussian parameters. On the other hand, it needs complex discrete convolution computations.First, this paper proposes an efficient pre‐image sample algorithm with outputs obeying irregular Gaussian distribution. Two measures are adopted to prevent the leakage of the geometrical property of trapdoor caused by irregular Gaussian outputs. A variant of MP trapdoor is proposed, and a new trapdoor is randomly assembled from a big enough space in each sample. Although still using a matrix as the Guassian parameter, in the proposed algorithm, the computational cost to set Gaussian parameters is zero. Meanwhile, the computational overhead for every sample is far less than that of MP sample algorithm. Second, to demonstrate the security and efficiency of the proposed sample algorithm, a hierarchical identity‐based signature scheme is put forward. This scheme is proved existentially unforgeable against selective identity adaptively chosen‐message attacks. Furthermore, the theoretical analysis shows that the proposed identity‐based signature is more efficient than the existing schemes. Copyright © 2016 John Wiley & Sons, Ltd.
Handling IoT platform heterogeneity with COISA, a compact OpenISA virtual platform
Authors: Auler Rafael , Millani Carlos Eduardo , Brisighello Alexandre , Linhares Alisson , Borin Edson 
Published: August 2016

SummaryIn face of the high number of different hardware platforms we need to program with Internet‐of‐Things (IoT), virtual machines (VMs) pose as a promising technology to allow a program once, deploy everywhere strategy. Unfortunately, existing VMs are either too heavy or use a stripped‐down version to work on resource‐constrained IoT devices. We present COISA, a compact virtual platform that relies on OpenISA, an instruction set architecture (ISA) that strives for easy emulation, to allow a single program to be deployed on many platforms, including tiny microcontrollers. By exploring the benefits of using a concrete ISA as our VM language, our experimental results indicate that COISA is easily portable and is capable of running unmodified guest applications in highly heterogeneous host platforms, including one with only 2 kB of RAM. For time‐critical IoT applications on constrained platforms where extracting performance is of paramount importance, we propose the use of cloud‐assisted translations, which employ static binary translation to deliver a binary fully converted to the native ISA used in the IoT device. Copyright © 2016 John Wiley & Sons, Ltd.