bluuebunny/crossref_metadata_2025_split huggingface dataset:
NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation
Authors: García-Carpizo Verónica , Sarmentero Jacinto , Han Bomie , Graña Osvaldo , Ruiz-Llorente Sergio , Pisano David G. , Serrano Manuel , Brooks Harold B. , Campbell Robert M. , Barrero Maria J. 
Published: September 2016

AbstractThe histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes to the proliferation of a subset of lung cancer cell lines by supporting oncogenic RAS transcriptional responses. NSD2 knock down combined with MEK or BRD4 inhibitors causes co-operative inhibitory responses on cell growth. However, while MEK and BRD4 inhibitors converge in the downregulation of genes associated with cancer-acquired super-enhancers, NSD2 inhibition affects the expression of clusters of genes embedded in megabase-scale regions marked with H3K36me2 and that contribute to the RAS transcription program. Thus, combinatorial therapies using MEK or BRD4 inhibitors together with NSD2 inhibition are likely to be needed to ensure a more comprehensive inhibition of oncogenic RAS-driven transcription programs in lung cancers with NSD2 overexpression.
Nanoionics and Nanocatalysts: Conformal Mesoporous Surface Scaffold for Cathode of Solid Oxide Fuel Cells
Authors: Chen Yun , Gerdes Kirk , Song Xueyan 
Published: September 2016

AbstractNanoionics has become increasingly important in devices and systems related to energy conversion and storage. Nevertheless, nanoionics and nanostructured electrodes development has been challenging for solid oxide fuel cells (SOFCs) owing to many reasons including poor stability of the nanocrystals during fabrication of SOFCs at elevated temperatures. In this study, a conformal mesoporous ZrO2 nanoionic network was formed on the surface of La1−xSrxMnO3/yttria-stabilized zirconia (LSM/YSZ) cathode backbone using Atomic Layer Deposition (ALD) and thermal treatment. The surface layer nanoionic network possesses open mesopores for gas penetration, and features a high density of grain boundaries for enhanced ion-transport. The mesoporous nanoionic network is remarkably stable and retains the same morphology after electrochemical operation at high temperatures of 650–800 °C for 400 hours. The stable mesoporous ZrO2 nanoionic network is further utilized to anchor catalytic Pt nanocrystals and create a nanocomposite that is stable at elevated temperatures. The power density of the ALD modified and inherently functional commercial cells exhibited enhancement by a factor of 1.5–1.7 operated at 0.8 V at 750 °C.
Recent Trends of Summer Convective and Stratiform Precipitation in Mid-Eastern China
Authors: Fu Yunfei , Chen Fengjiao , Liu Guosheng , Yang Yuanjian , Yuan Renmin , Li Rui , Liu Qi , Wang Yu , Zhong Lei , Sun Liang 
Published: September 2016

AbstractMany studies have reported on the trends of precipitation in Mid-Eastern China (EC). However, the trends of convective and stratiform precipitation are still unknown. Here, we examine the trends of summer convective and stratiform precipitation in EC from 2002 to 2012 on the basis of the TRMM observations. Results revealed that the rain frequency (RF) for both convective and stratiform precipitation increased in majority regions of Southern EC (SEC), but decreased in Northwest part of Northern EC (NEC). The decreasing rate of RF for stratiform precipitation in NEC is twice as much as that for convective precipitation, while the increase of convective precipitation in SEC is more evident than stratiform precipitation. The rain rate (RR) exhibited a decreasing trend in most portions of EC for both convective and stratiform precipitation. In SEC, neither PW nor WVT has good ability in explaining the precipitation variability. However, in NEC, PW is closely correlated to convective RF and WVT is more closely related to stratiform RF.
Acoustic structure quantification by using ultrasound Nakagami imaging for assessing liver fibrosis
Authors: Tsui Po-Hsiang , Ho Ming-Chih , Tai Dar-In , Lin Ying-Hsiu , Wang Chiao-Yin , Ma Hsiang-Yang 
Published: September 2016

AbstractAcoustic structure quantification (ASQ) is a recently developed technique widely used for detecting liver fibrosis. Ultrasound Nakagami parametric imaging based on the Nakagami distribution has been widely used to model echo amplitude distribution for tissue characterization. We explored the feasibility of using ultrasound Nakagami imaging as a model-based ASQ technique for assessing liver fibrosis. Standard ultrasound examinations were performed on 19 healthy volunteers and 91 patients with chronic hepatitis B and C (n = 110). Liver biopsy and ultrasound Nakagami imaging analysis were conducted to compare the METAVIR score and Nakagami parameter. The diagnostic value of ultrasound Nakagami imaging was evaluated using receiver operating characteristic (ROC) curves. The Nakagami parameter obtained through ultrasound Nakagami imaging decreased with an increase in the METAVIR score (p < 0.0001), representing an increase in the extent of pre-Rayleigh statistics for echo amplitude distribution. The area under the ROC curve (AUROC) was 0.88 for the diagnosis of any degree of fibrosis (≥F1), whereas it was 0.84, 0.69, and 0.67 for ≥F2, ≥F3, and ≥F4, respectively. Ultrasound Nakagami imaging is a model-based ASQ technique that can be beneficial for the clinical diagnosis of early liver fibrosis.
Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network meta-analysis
Authors: Li Shu , Yang Hongxi , Guo Yanan , Wei Fengjiang , Yang Xilin , Li Daiqing , Li Mingzhen , Xu Weili , Li Weidong , Sun Li , Gao Ying , Wang Yaogang 
Published: September 2016

AbstractThe prevalence of hyperuricemia and gout has been increasing, but the comparative effectiveness and safety of different treatments remain uncertain. We aimed to compare the effectiveness and safety of different treatments for hyperuricemia using network meta-analysis methodology. We systematically reviewed fifteen randomized controlled trials (involving 7,246 patients through January 2016) that compared the effects of different urate-lowering drugs (allopurinol, benzbromarone, febuxostat, pegloticase and probenecid) on hyperuricemia. Drug efficacy and safety, as outcomes, were measured by whether the target level of serum urate acid was achieved and whether any adverse events occurred, respectively. We derived pooled effect sizes expressed as odds ratios (ORs) and 95% confidence intervals (CIs). The efficacy and safety of the drugs were ranked by cumulative ranking probabilities. Our findings show that febuxostat, benzbromarone, probenecid, pegloticase, and allopurinol were all highly effective at reducing the risk of hyperuricemia compared to placebo. Febuxostat had the best efficacy and safety compared to the other drugs. Furthermore, febuxostat 120 mg QD was more effective at achieving urate-lowering targets (OR: 0.17, 95% CI: 0.12–0.24) and safer (OR: 0.72, 95% CI: 0.56–0.91) than allopurinol.
A Modified Theoretical Model of Intrinsic Hardness of Crystalline Solids
Authors: Dai Fu-Zhi , Zhou Yanchun 
Published: September 2016

AbstractSuper-hard materials have been extensively investigated due to their practical importance in numerous industrial applications. To stimulate the design and exploration of new super-hard materials, microscopic models that elucidate the fundamental factors controlling hardness are desirable. The present work modified the theoretical model of intrinsic hardness proposed by Gao. In the modification, we emphasize the critical role of appropriately decomposing a crystal to pseudo-binary crystals, which should be carried out based on the valence electron population of each bond. After modification, the model becomes self-consistent and predicts well the hardness values of many crystals, including crystals composed of complex chemical bonds. The modified model provides fundamental insights into the nature of hardness, which can facilitate the quest for intrinsic super-hard materials.
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis
Authors: Nan Ling , Jacko Anastasia M. , Tan Jiangning , Wang Dan , Zhao Jing , Kass Daniel J. , Ma Haichun , Zhao Yutong 
Published: September 2016

AbstractTransforming growth factor β-1 (TGFβ-1)-induced phosphorylation of transcription factors Smad2 and Smad3 plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the molecular regulation of Smad2/Smad3 proteins stability remains a mystery. Here, we show that ubiquitin carboxyl-terminal hydrolase-L5 (UCHL5 or UCH37) de-ubiquitinates both Smad2 and Smad3, up-regulates their stability, and promotes TGFβ-1-induced expression of profibrotic proteins, such as fibronectin (FN) and α-smooth muscle actin (α-SMA). Inhibition or down-regulation of UCHL5 reduced Smad2/Smad3 levels and TGFβ-1-induced the expression of FN and α-SMA in human lung fibroblast. We demonstrate that Smad2 and Smad3 ubiquitination was diminished by over-expression of UCHL5, while it was enhanced by inhibition or down-regulation of UCHL5. UCHL5 is highly expressed in IPF lungs. UCHL5, Smad2, and Smad3 levels were increased in bleomycin-injured lungs. Administration of UCHL5 inhibitor, b-AP15, reduced the expression of FN, type I collagen, Smad2/Smad3, and the deposition of collagen in lung tissues in a bleomycin-induced model of pulmonary fibrosis. Our studies provide a molecular mechanism by which UCHL5 mitigates TGFβ-1 signaling by stabilizing Smad2/Smad3. These data indicate that UCHL5 may contribute to the pathogenesis of IPF and may be a potential therapeutic target.
Origin of high thermoelectric performance of FeNb1−xZr/HfxSb1−ySny alloys: A first-principles study
Authors: Zhang Xiwen , Wang Yuanxu , Yan Yuli , Wang Chao , Zhang Guangbiao , Cheng Zhenxiang , Ren Fengzhu , Deng Hao , Zhang Jihua 
Published: September 2016

AbstractThe previous experimental work showed that Hf- or Zr-doping has remarkably improved the thermoelectric performance of FeNbSb. Here, the first-principles method was used to explore the possible reason for such phenomenon. The substitution of X (Zr/Hf) atoms at Nb sites increases effective hole-pockets, total density of states near the Fermi level (EF), and hole mobility to largely enhance electrical conductivity. It is mainly due to the shifting the EF to lower energy and the nearest Fe atoms around X atoms supplying more d-states to hybrid with X d-states at the vicinity of the EF. Moreover, we find that the X atoms indirectly affect the charge distribution around Nb atoms via their nearest Fe atoms, resulting in the reduced energy difference in the valence band edge, contributing to enhanced Seebeck coefficients. In addition, the further Bader charge analysis shows that the reason of more holes by Hf-doping than Zr in the experiment is most likely derived from Hf atoms losing less electrons and the stronger hybridization between Hf atoms and their nearest Fe atoms. Furthermore, we predict that Hf/Sn co-doping may be an effective strategy to further optimize the thermoelectric performance of half-Heusler (HH) compounds.
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells
Authors: Chi Mengna , Evans Hamish , Gilchrist Jackson , Mayhew Jack , Hoffman Alexander , Pearsall Elizabeth Ann , Jankowski Helen , Brzozowski Joshua Stephen , Skelding Kathryn Anne 
Published: September 2016

AbstractCalcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional kinase that controls a range of cellular functions, including proliferation, differentiation and apoptosis. The biological properties of CaMKII are regulated by multi-site phosphorylation. However, the role that CaMKII phosphorylation plays in cancer cell metastasis has not been examined. We demonstrate herein that CaMKII expression and phosphorylation at T286 is increased in breast cancer when compared to normal breast tissue, and that increased CAMK2 mRNA is associated with poor breast cancer patient prognosis (worse overall and distant metastasis free survival). Additionally, we show that overexpression of WT, T286D and T286V forms of CaMKII in MDA-MB-231 and MCF-7 breast cancer cells increases invasion, migration and anchorage independent growth, and that overexpression of the T286D phosphomimic leads to a further increase in the invasive, migratory and anchorage independent growth capacity of these cells. Pharmacological inhibition of CaMKII decreases MDA-MB-231 migration and invasion. Furthermore, we demonstrate that overexpression of T286D, but not WT or T286V-CaMKII, leads to phosphorylation of FAK, STAT5a, and Akt. These results demonstrate a novel function for phosphorylation of CaMKII at T286 in the control of breast cancer metastasis, offering a promising target for the development of therapeutics to prevent breast cancer metastasis.
Performance enhancement of ground radiation antenna for Z‐wave applications using tunable metal loads
Authors: Qu L. , Zhang R. , Shin H. , Kim J. , Kim H. 
Published: September 2016

A ground radiation antenna with tunable metal loads is proposed to improve the performance of a normal antenna at 900 MHz for Z‐wave applications. The proposed design is comprised of a 5 mm × 5 mm ground radiation antenna and inductor‐connected metal loads in a 30 × 50 mm ground plane. The metal loads can take the form of rims, a frame, strips, or wires at the ends of the ground plane and are connected with lumped elements to allow easy adjustment. The proposed antenna was simulated to tune the metal loads, and was then fabricated and measured to verify its improved performance in the Z‐wave band.
Two‐step injection clock generation technique for fractional‐N MDLL
Authors: Jee D.‐W. 
Published: September 2016

Two‐step injection clock generation technique is presented for fine resolution fractional‐N multiplying delay‐locked loop (MDLL). The coarse DLL generates multiple coarse clock phases, and then fine DLL performs fine phase control for MDLL injection clock. The proposed technique is applied to fractional‐N MDLL and efficiently achieves 8b fractional frequency resolution. The MDLL designed in a 0.18 μm CMOS process occupies 0.065 mm2 and generates 10 MHz frequency with 61 μW power consumption.
Semi‐analytical small signal parameter extraction method for PIN photodiode
Authors: Xu Zhixia , Gao Jianjun 
Published: September 2016

A parameter extraction method to determine the parameters of small signal equivalent circuit model for PIN photodiodes is proposed in this study, which combines the analytical approach and the empirical optimisation procedure. The equations used for extraction and the extracted parameters of circuit elements are presented. Good agreement is obtained between the simulated and measured S ‐parameters up to 40 GHz.
Olivine anisotropy suggests Gutenberg discontinuity is not the base of the lithosphere
Authors: Hansen Lars N. , Qi Chao , Warren Jessica M. 
Published: September 2016

Significance
Although plate tectonics has seen broad acceptance for Earth, the manner in which lithospheric plates are coupled to Earth’s deeper interior is still heavily debated. In particular, recent seismological observations suggest a sharp, flat base of the lithosphere, whereas thermal models suggest a gradational boundary that deepens with age. Based on laboratory experiments, we suggest that thermal models are most appropriate and that seismic studies are detecting features frozen into the lithosphere after melting at midocean ridges. Experiments on olivine aggregates demonstrate that the seismic characteristics of deforming upper mantle are dramatically different between melt-free and low-melt-fraction aggregates. A model of upper-mantle flow incorporating these results predicts seismological features in excellent agreement with observations beneath the Pacific Ocean basin.
Thermoneutral immersion exercise accelerates heart rate recovery: A potential novel training modality
Authors: Garzon Mauricio , Dupuy Olivier , Bosquet Laurent , Nigam Anil , Comtois Alain Steve , Juneau Martin , Gayda Mathieu 
Published: September 2016

AbstractThis study compared heart rate recovery (HRR) after incremental maximal exercise performed at the same external power output (Pext) on dry land ergocycle (DE) vs. immersible ergocycle (IE). Fifteen young healthy participants (30 ± 7 years, 13 men and 2 women) performed incremental maximal exercise tests on DE and on IE. The initial Pext on DE was 25 W and was increased by 25 W/min at a pedalling cadence between 60 and 80 rpm, while during IE immersion at chest level in thermoneutral water (30°C), the initial Pext deployment was at a cadence of 40 rpm which was increased by 10 rpm until 70 rpm and thereafter by 5 rpm until exhaustion. Gas exchange and heart rate (HR) were measured continuously during exercise and recovery for 5 min. Maximal HR (DE: 176 ± 15 vs. IE 169 ± 12 bpm) reached by the subjects in the two conditions did not differ (P > .05). Parasympathetic reactivation parameters (ΔHR from 10 to 300 s) were compared during the DE and IE HR recovery recordings. During the IE recovery, parasympathetic reactivation in the early phase was more predominant (HRR at Δ10–Δ60 s, P < .05), but similar in the late phase (HRR at Δ120–Δ300 s, P > .05) when compared to the DE condition. In conclusion, incremental maximal IE exercise at chest level immersion in thermoneutral water accelerates the early phase parasympathetic reactivation compared to DE in healthy young participants.
Modelling plasma response to RMP fields in ASDEX Upgrade with varying edge safety factor and triangularity
Authors: Li L. , Liu Y.Q. , Kirk A. , Wang N. , Liang Y. , Ryan D. , Suttrop W. , Dunne M. , Fischer R. , Fuchs J.C. , Kurzan B. , Piovesan P. , Willensdorfer M. , Zhong F.C. 
Published: September 2016

Abstract
Toroidal computations are performed using the MARS-F code (Liu et al 2000 Phys. Plasmas
7 3681), in order to understand correlations between the plasma response and the observed mitigation of the edge localized modes (ELM) using resonant magnetic perturbation fields in ASDEX Upgrade. In particular, systematic numerical scans of the edge safety factor reveal that the amplitude of the resonant poloidal harmonic of the response radial magnetic field near the plasma edge, as well as the plasma radial displacement near the X-point, can serve as good indicators for predicting the optimal toroidal phasing between the upper and lower rows of coils in ASDEX Upgrade. The optimal coil phasing scales roughly linearly with the edge safety factor

q

95

, for various choices of the toroidal mode number n  =  1–4 of the coil configuration. The optimal coil phasing is also predicted to vary with the upper triangularity of the plasma shape in ASDEX Upgrade. Furthermore, multiple resonance effects of the plasma response, with continuously varying

q

95

, are computationally observed and investigated.
Coercivity of weighted Kohn Laplacians: The case of model monomial weights in ℂ²
Authors: Dall’Ara Gian Maria 
Published: September 2016

The weighted Kohn Laplacian

◻

φ

\Box _\varphi

is a natural second order elliptic operator associated to a weight

φ
:

C

n

→

R

\varphi :\mathbb {C}^n\rightarrow \mathbb {R}

and acting on

(
0
,
1
)

(0,1)

-forms, which plays a key role in several questions of complex analysis.

We consider here the case of model monomial weights in

C

2

\mathbb {C}^2

, i.e.,
\[

φ
(
z
,
w
)
:=

∑

(
α
,
β
)
∈
Γ

|

z
α

w
β

|

2

,

\varphi (z,w):=\sum _{(\alpha ,\beta )\in \Gamma }|z^\alpha w^\beta |^2,

\]
where

Γ
⊆

N

2

\Gamma \subseteq \mathbb {N}^2

is finite. Our goal is to prove coercivity estimates of the form
\[

(
∗
)

◻

φ

≥

μ
2

,

(*)\hspace {10pc} \Box _\varphi \geq \mu ^2,\hspace {10pc}

\]
where

μ
:

C

n

→

R

\mu :\mathbb {C}^n\rightarrow \mathbb {R}

acts by pointwise multiplication on

(
0
,
1
)

(0,1)

-forms, and the inequality is in the sense of self-adjoint operators. We proved in 2015 how to derive from

(
∗
)

(*)

new pointwise bounds for the weighted Bergman kernel associated to

φ
\varphi

. Here we introduce a technique to establish

(
∗
)

(*)

with
\[

μ
(
z
,
w
)
=
c
(
1
+

|

z

|

a

+

|

w

|

b

)

(
a
,
b
≥
0
)
,

\mu (z,w)=c(1+|z|^a+|w|^b) \qquad (a,b\geq 0),

\]
where

a
,
b
≥
0

a,b\geq 0

depend on (and are easily computable from)

Γ
\Gamma

. As a corollary we also prove that, for a wide class of model monomial weights, the spectrum of

◻

φ

\Box _\varphi

is discrete if and only if the weight is not decoupled, i.e.,

Γ
\Gamma

contains at least a point

(
α
,
β
)

(\alpha ,\beta )

with

α
≠
0
≠
β

\alpha \neq 0\neq \beta

.

Our methods comprise a new holomorphic uncertainty principle and linear optimization arguments.
Consequences of catch-and-release angling for black bream Spondyliosoma cantharus, during the parental care period: implications for management
Authors: Pinder Adrian C. , Velterop Randolph , Cooke Steven J. , Britton J. Robert 
Published: September 2016

Black sea bream Spondyliosoma cantharus is highly valued for its sporting and eating qualities. Due to its inshore spawning aggregations and male nest guarding behaviors, it is considered vulnerable to over-exploitation via recreational angling. Accordingly, greater uptake of the practice of catch-and-release (C&R) may provide some potential to limit the effects of angling on populations. Thus, the consequences of C&R for 40 S. cantharus (mean length 306 ± 10 mm) were assessed. Fish were sampled following their capture from charter boats by recreational anglers with varying levels of skill and experience. Of these fish, 17% were deeply hooked (e.g. in esophagus) and considered at high risk of post-release mortality (PRM). Blood lactate levels ranged between 0.40 and 2.60 mmol l − 1 (mean ± SE: 1.25 ± 0.09) and were significantly and positively correlated with fight time. Reflex impairments were observed in 32% of the catch, also suggesting an elevated probability of PRM. Hook damage was the only significant predictor of reflex impairment. The dominance of males (89%) across the catches highlighted the potential for additional indirect impacts of angling via the predation of eggs by conspecifics in the vacated nests of captured males. These results are discussed within the context of post-release performance of individual S. cantharus, the potential for C&R to limit impact at the population level and a need to consider future regulation of the fishery to ensure sustainability of stocks.