bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mealtime habits and risk of developing the metabolic syndrome or insulin resistance among Mexican adults
Authors: Méndez-Hernández Pablo , Dosamantes-Carrasco Libia Darina , Siani Carole , Pierlot Romain , Martínez-Gómez Margarita , Rivera-Paredez Berenice , Cervantes-Popoca Laura , Rojas-Lima Elodia , Salazar-Martínez Eduardo , Flores Yvonne N. , Salmerón Jorge 
Published: November 2016

AbstractMeals are an important source of food intake, contributing to body weight and health status. Previous studies have examined the relationship between isolated mealtime behaviours and the metabolic syndrome (MetS). The aim of this study was to examine the influence over time of ten interrelated mealtime habits on the risk of developing the MetS and insulin resistance (IR) among Mexican adults. We conducted a prospective cohort study with a sample of 956 health workers. The Mealtime Habits Quality (MHQ) scale is based on four mealtime situations (availability of time to eat, distractions while eating, environmental and social context of eating, and familiar or cultural eating habits), which were used to assess the participants’ MHQ at the baseline (2004–2006) and follow-up (2010–2012) evaluations. The MetS was assessed using criteria from the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation (IDF). IR was defined using the homoeostasis model assessment. Crude and adjusted relative risks were calculated to estimate the relationship between MHQ and the risk of developing the MetS or IR. Participants classified in the lower MHQ category had an 8·8 (95 % CI 3·1, 25) and 11·1 (95 % CI 3·4, 36·1) times greater risk of developing the MetS (using the NCEP-ATP III and IDF criteria, respectively), and an 11·2 times (95 % CI 3·9, 31·5) greater likelihood of developing IR, compared with those in the higher MHQ group. This prospective study reveals that individuals who engaged in more undesirable than recommended mealtime behaviours had a >10-fold risk of developing the MetS or IR.
DIFFERENT WAYS TO CUT A CAKE: COMPARING EXPERT-BASED AND STATISTICAL TYPOLOGIES TO TARGET SUSTAINABLE INTENSIFICATION TECHNOLOGIES, A CASE-STUDY IN SOUTHERN ETHIOPIA
Authors: BERRE DAVID , BAUDRON FRÉDÉRIC , KASSIE MENALE , CRAUFURD PETER , LOPEZ-RIDAURA SANTIAGO 
Published: November 2016

SUMMARYUnderstanding farm diversity is essential to delineate recommendation domains for new technologies, but diversity is a subjective concept, and can be described differently depending on the way it is perceived. Historically, new technologies have been targeted primarily based on agro-ecological conditions, largely ignoring socioeconomic conditions. Based on 273 farm households' surveys in Ethiopia, we compare two approaches for the delineation of farm type recommendation domains for crop and livestock technologies: one based on expert knowledge and one based on statistical methods. The expert-based typology used a simple discriminant key for stakeholders in the field to define four farm types based on Tropical Livestock Unit, total cultivated surface and the ratio of these two indicators. This simple key took only a few minutes to make inferences about the potential of adoption of crop and livestock technologies. The PCA-HC analysis included a greater number of variables describing the farm (land use, household size, cattle, fertilizer, off-farm work, hiring labour, production). This analysis emphasized the multi-dimensional potential of such a statistical approach and, in principle, its usefulness to grasp the full complexity of farming systems to identify their needs in crop and livestock technologies. A sub-sampling approach was used to test the impact of data selection on the diversity represented in the statistical approach. Our results show that diversity structure is significantly impacted according to the choice of a sub-sample of 15 of the 20 variables available. This paper shows the complementarity of the two approaches and demonstrates the influence of data selection within large baseline data sets on the total diversity represented in the clusters identified.
Let's talk about sex – what do older men and women say about their sexual relations and sexual activities? A qualitative analysis of ELSA Wave 6 data
Authors: TETLEY JOSIE , LEE DAVID M. , NAZROO JAMES , HINCHLIFF SHARRON 
Published: November 2016

ABSTRACTIn 2012/2013 the English Longitudinal Study of Ageing (ELSA) included a comprehensive Sexual Relationships and Activities Questionnaire (SRA-Q). A total of 7,079 men and women mainly aged 50 to >90, primarily heterosexual and in a coupled relationship, completed the SRA-Q, answering a series of questions about their attitudes to sexual relationships, their own sexual activities, problems and concerns with sexual functioning, and quality of intimate relationships. The questions aimed to gain insights into the ways in which sexual relations and activities related to health, wellbeing and other lifestyle factors change as people grow older. The primary mode of data collection was a tick box response to a series of questions. However, at the end of the questionnaire an open comment box was provided, which asked respondents whether there was anything else that they would like to say; 1,084 respondents provided additional information and these comments created a unique qualitative data-set. The analysis of the data then illustrated how people's health, relationships, experiences and perceptions of ageing, along with sexual satisfaction, impact on sexual relationships and activities.
Contested evidence: a Dutch reimbursement decision taken to court
Authors: Moes Floortje , Houwaart Eddy , Delnoij Diana , Horstman Klasien 
Published: November 2016

AbstractThis paper examines a remarkable lawsuit in health care rationing. The Patients Association for Interstitial Cystitis sued the Dutch National Health Care Institute for alleged misconduct against Interstitial Cystitis patients, as the Institute decided that bladder instillations with chondroitin sulphate or hyaluronic acid are no longer covered by the basic health insurance. The patients’ organisation challenged the Institute for basing its standpoint on scientific evidence; overruling clinical expertise and patients’ experiences. While scientific advice is often solicited in public health issues, simultaneously, the authority of scientific advice is increasingly being questioned in the public domain. Also, the judiciary is frequently called upon to adjudicate in rationing decisions. Based on an ethnographic study of the National Health Care Institute, drawing on insights from the field of Science and Technology Studies, we analyse this lawsuit as a negotiation of what knowledge counts in reimbursement decisions.
NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis
Authors: Jeter Collene R , Liu Bigang , Lu Yue , Chao Hsueh-Ping , Zhang Dingxiao , Liu Xin , Chen Xin , Li Qiuhui , Rycaj Kiera , Calhoun-Davis Tammy , Yan Li , Hu Qiang , Wang Jianmin , Shen Jianjun , Liu Song , Tang Dean G 
Published: November 2016

AbstractThe pluripotency transcription factor NANOG has been implicated in tumor development, and NANOG-expressing cancer cells manifest stem cell properties that sustain tumor homeostasis, mediate therapy resistance and fuel tumor progression. However, how NANOG converges on somatic circuitry to trigger oncogenic reprogramming remains obscure. We previously reported that inducible NANOG expression propels the emergence of aggressive castration-resistant prostate cancer phenotypes. Here we first show that endogenous NANOG is required for the growth of castration-resistant prostate cancer xenografts. Genome-wide chromatin immunoprecipitation sequencing coupled with biochemical assays unexpectedly reveals that NANOG co-occupies a distinctive proportion of androgen receptor/Forkhead box A1 genomic loci and physically interacts with androgen receptor and Forkhead box A1. Integrative analysis of chromatin immunoprecipitation sequencing and time-resolved RNA sequencing demonstrates that NANOG dynamically alters androgen receptor/Forkhead box A1 signaling leading to both repression of androgen receptor-regulated pro-differentiation genes and induction of genes associated with cell cycle, stem cells, cell motility and castration resistance. Our studies reveal global molecular mechanisms whereby NANOG reprograms prostate cancer cells to a clinically relevant castration-resistant stem cell-like state driven by distinct NANOG-regulated gene clusters that correlate with patient survival. Thus, reprogramming factors such as NANOG may converge on and alter lineage-specific master transcription factors broadly in somatic cancers, thereby facilitating malignant disease progression and providing a novel route for therapeutic resistance.
Multidimensional heritability analysis of neuroanatomical shape
Authors: Ge Tian , Reuter Martin , Winkler Anderson M. , Holmes Avram J. , Lee Phil H. , Tirrell Lee S. , Roffman Joshua L. , Buckner Randy L. , Smoller Jordan W. , Sabuncu Mert R. 
Published: November 2016

AbstractIn the dawning era of large-scale biomedical data, multidimensional phenotype vectors will play an increasing role in examining the genetic underpinnings of brain features, behaviour and disease. For example, shape measurements derived from brain MRI scans are multidimensional geometric descriptions of brain structure and provide an alternate class of phenotypes that remains largely unexplored in genetic studies. Here we extend the concept of heritability to multidimensional traits, and present the first comprehensive analysis of the heritability of neuroanatomical shape measurements across an ensemble of brain structures based on genome-wide SNP and MRI data from 1,320 unrelated, young and healthy individuals. We replicate our findings in an extended twin sample from the Human Connectome Project (HCP). Our results demonstrate that neuroanatomical shape can be significantly heritable, above and beyond volume, and can serve as a complementary phenotype to study the genetic determinants and clinical relevance of brain structure.
Smectic phase in suspensions of gapped DNA duplexes
Authors: Salamonczyk Miroslaw , Zhang Jing , Portale Giuseppe , Zhu Chenhui , Kentzinger Emmanuel , Gleeson James T. , Jakli Antal , De Michele Cristiano , Dhont Jan K. G. , Sprunt Samuel , Stiakakis Emmanuel 
Published: November 2016

AbstractSmectic ordering in aqueous solutions of monodisperse stiff double-stranded DNA fragments is known not to occur, despite the fact that these systems exhibit both chiral nematic and columnar mesophases. Here, we show, unambiguously, that a smectic-A type of phase is formed by increasing the DNA’s flexibility through the introduction of an unpaired single-stranded DNA spacer in the middle of each duplex. This is unusual for a lyotropic system, where flexibility typically destabilizes the smectic phase. We also report on simulations suggesting that the gapped duplexes (resembling chain-sticks) attain a folded conformation in the smectic layers, and argue that this layer structure, which we designate as smectic-fA phase, is thermodynamically stabilized by both entropic and energetic contributions to the system’s free energy. Our results demonstrate that DNA as a building block offers an exquisitely tunable means to engineer a potentially rich assortment of lyotropic liquid crystals.
Bivalence Mn5O8 with hydroxylated interphase for high-voltage aqueous sodium-ion storage
Authors: Shan Xiaoqiang , Charles Daniel S. , Lei Yinkai , Qiao Ruimin , Wang Guofeng , Yang Wanli , Feygenson Mikhail , Su Dong , Teng Xiaowei 
Published: November 2016

AbstractAqueous electrochemical energy storage devices have attracted significant attention owing to their high safety, low cost and environmental friendliness. However, their applications have been limited by a narrow potential window (∼1.23 V), beyond which the hydrogen and oxygen evolution reactions occur. Here we report the formation of layered Mn5O8 pseudocapacitor electrode material with a well-ordered hydroxylated interphase. A symmetric full cell using such electrodes demonstrates a stable potential window of 3.0 V in an aqueous electrolyte, as well as high energy and power performance, nearly 100% coulombic efficiency and 85% energy efficiency after 25,000 charge–discharge cycles. The interplay between hydroxylated interphase on the surface and the unique bivalence structure of Mn5O8 suppresses the gas evolution reactions, offers a two-electron charge transfer via Mn2+/Mn4+ redox couple, and provides facile pathway for Na-ion transport via intra-/inter-layer defects of Mn5O8.
BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
Authors: Rasmussen Rikke D. , Gajjar Madhavsai K. , Tuckova Lucie , Jensen Kamilla E. , Maya-Mendoza Apolinar , Holst Camilla B. , Møllgaard Kjeld , Rasmussen Jane S. , Brennum Jannick , Bartek Jiri , Syrucek Martin , Sedlakova Eva , Andersen Klaus K. , Frederiksen Marie H. , Bartek Jiri , Hamerlik Petra 
Published: November 2016

AbstractOncogene-evoked replication stress (RS) fuels genomic instability in diverse cancer types. Here we report that BRCA1, traditionally regarded a tumour suppressor, plays an unexpected tumour-promoting role in glioblastoma (GBM), safeguarding a protective response to supraphysiological RS levels. Higher BRCA1 positivity is associated with shorter survival of glioma patients and the abrogation of BRCA1 function in GBM enhances RS, DNA damage (DD) accumulation and impairs tumour growth. Mechanistically, we identify a novel role of BRCA1 as a transcriptional co-activator of RRM2 (catalytic subunit of ribonucleotide reductase), whereby BRCA1-mediated RRM2 expression protects GBM cells from endogenous RS, DD and apoptosis. Notably, we show that treatment with a RRM2 inhibitor triapine reproduces the BRCA1-depletion GBM-repressive phenotypes and sensitizes GBM cells to PARP inhibition. We propose that GBM cells are addicted to the RS-protective role of the BRCA1-RRM2 axis, targeting of which may represent a novel paradigm for therapeutic intervention in GBM.
Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor
Authors: Piscuoglio Salvatore , Geyer Felipe C , Burke Kathleen A , Murray Melissa P , Ng Charlotte KY , Mota Alba , Marchio Caterina , Berman Samuel H , Norton Larry , Brogi Edi , Weigelt Britta , Reis-Filho Jorge S 
Published: November 2016

AbstractPhyllodes tumors (PTs) and fibroadenomas (FAs) are fibroepithelial lesions (FELs) of the breast. Although mutations affecting exon 2 of MED12 are highly recurrent in FAs and PTs, TERT promoter hotspot mutations are frequently found in PTs but are vanishingly rare in FAs. Malignant transformation of benign PTs is well-documented, but the progression from FA to PT remains a matter of contention. Here we report on the somatic genetic alterations in multiple ipsilateral synchronous FELs (three FAs, one benign PT, and one malignant PT) occurring in the same patient. DNA samples extracted from each tumor and matched normal tissue were subjected to targeted massively parallel sequencing using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay. This analysis revealed MED12 mutations in all lesions. One FA and the benign PT harbored a MED12Gly44Val mutation, whereas another FA and the malignant PT displayed a MED12Gly44Asp mutation. The remaining FA had an independent distinct MED12Gly44Cys mutation. A formal clonality analysis suggested a clonal relationship between the FELs with identical MED12 mutations (P<0.05). A clonal TERT promoter hotspot mutation was identified exclusively in the malignant PT. The identification of distinct MED12 mutations in multifocal ipsilateral and synchronous FELs supports the notion that co-existing mammary fibroepithelial tumors can arise independently. Conversely, the co-existence of identical MED12 mutations indicates clonal relatedness among FAs and PTs, corroborating the hypothesis that FAs may constitute the substrate from which PTs develop. Our findings also support the notion that acquisition of TERT promoter mutations may drive the progression of FELs.
An efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate
Authors: Fiebig Timm , Romano Maria Rosaria , Oldrini Davide , Adamo Roberto , Tontini Marta , Brogioni Barbara , Santini Laura , Berger Monika , Costantino Paolo , Berti Francesco , Gerardy-Schahn Rita 
Published: November 2016

AbstractInvasive meningococcal disease (IMD) is a global health problem and vaccination has proven the most effective way of disease control. Neisseria meningitidis serogroup X (NmX) is an emerging threat in the African sub-Saharan meningitis belt, but no vaccine is available today. Leading vaccines against Nm are glycoconjugates, in which capsular polysaccharides isolated from large-scale pathogen cultures are conjugated to adjuvant proteins. Though safe and efficacious even in infants, high costs and biohazard associated with the production limit abundant application of glycoconjugate vaccines particularly in the most afflicted nations. An existing NmX vaccine candidate (CPSXn-CRM197) produced by established protocols from NmX capsule polysaccharide (CPSX) has been shown to elicit high bactericidal immunoglobulin G titres in mice. Here we describe the scalable in vitro synthesis of CPSXiv from chemically pure precursors by the use of recombinant NmX capsule polymerase. Application of the described coupling chemistry gives CPSXiv-CRM197, which in mouse vaccination experiments behaves identical to the benchmark CPSXn-CRM197. Excluding any biohazards, this novel process represents a paradigm shift in vaccine production and a premise towards vaccine manufacturing in emerging economies.
Habitual coffee consumption and risk of type 2 diabetes, ischemic heart disease, depression and Alzheimer’s disease: a Mendelian randomization study
Authors: Kwok Man Ki , Leung Gabriel M. , Schooling C. Mary 
Published: November 2016

AbstractObservationally, coffee is inversely associated with type 2 diabetes mellitus (T2DM), depression and Alzheimer’s disease, but not ischemic heart disease (IHD). Coffee features as possibly protective in the 2015 Dietary Guidelines for Americans. Short-term trials suggest coffee has neutral effect on most glycemic traits, but raises lipids and adiponectin. To clarify we compared T2DM, depression, Alzheimer’s disease, and IHD and its risk factors by genetically predicted coffee consumption using two-sample Mendelian randomization applied to large extensively genotyped case-control and cross-sectional studies. Childhood cognition was used as a negative control outcome. Genetically predicted coffee consumption was not associated with T2DM (odds ratio (OR) 1.02, 95% confidence interval (CI) 0.76 to 1.36), depression (0.89, 95% CI 0.66 to 1.21), Alzheimer’s disease (1.17, 95% CI 0.96 to 1.43), IHD (0.96, 95% CI 0.80 to 1.14), lipids, glycemic traits, adiposity or adiponectin. Coffee was unrelated to childhood cognition. Consistent with observational studies, coffee was unrelated to IHD, and, as expected, childhood cognition. However, contrary to observational findings, coffee may not have beneficial effects on T2DM, depression or Alzheimer’s disease. These findings clarify the role of coffee with relevance to dietary guidelines and suggest interventions to prevent these complex chronic diseases should be sought elsewhere.
Gesture recognition by instantaneous surface EMG images
Authors: Geng Weidong , Du Yu , Jin Wenguang , Wei Wentao , Hu Yu , Li Jiajun 
Published: November 2016

AbstractGesture recognition in non-intrusive muscle-computer interfaces is usually based on windowed descriptive and discriminatory surface electromyography (sEMG) features because the recorded amplitude of a myoelectric signal may rapidly fluctuate between voltages above and below zero. Here, we present that the patterns inside the instantaneous values of high-density sEMG enables gesture recognition to be performed merely with sEMG signals at a specific instant. We introduce the concept of an sEMG image spatially composed from high-density sEMG and verify our findings from a computational perspective with experiments on gesture recognition based on sEMG images with a classification scheme of a deep convolutional network. Without any windowed features, the resultant recognition accuracy of an 8-gesture within-subject test reached 89.3% on a single frame of sEMG image and reached 99.0% using simple majority voting over 40 frames with a 1,000 Hz sampling rate. Experiments on the recognition of 52 gestures of NinaPro database and 27 gestures of CSL-HDEMG database also validated that our approach outperforms state-of-the-arts methods. Our findings are a starting point for the development of more fluid and natural muscle-computer interfaces with very little observational latency. For example, active prostheses and exoskeletons based on high-density electrodes could be controlled with instantaneous responses.
Non-uniform Evolving Hypergraphs and Weighted Evolving Hypergraphs
Authors: Guo Jin-Li , Zhu Xin-Yun , Suo Qi , Forrest Jeffrey 
Published: November 2016

AbstractFirstly, this paper proposes a non-uniform evolving hypergraph model with nonlinear preferential attachment and an attractiveness. This model allows nodes to arrive in batches according to a Poisson process and to form hyperedges with existing batches of nodes. Both the number of arriving nodes and that of chosen existing nodes are random variables so that the size of each hyperedge is non-uniform. This paper establishes the characteristic equation of hyperdegrees, calculates changes in the hyperdegree of each node, and obtains the stationary average hyperdegree distribution of the model by employing the Poisson process theory and the characteristic equation. Secondly, this paper constructs a model for weighted evolving hypergraphs that couples the establishment of new hyperedges, nodes and the dynamical evolution of the weights. Furthermore, what is obtained are respectively the stationary average hyperdegree and hyperstrength distributions by using the hyperdegree distribution of the established unweighted model above so that the weighted evolving hypergraph exhibits a scale-free behavior for both hyperdegree and hyperstrength distributions.
Occurrence and source apportionment of Per- and poly-fluorinated compounds (PFCs) in North Canal Basin, Beijing
Authors: Zhang Yi-Zhe , Wang Bin , Wang Wei , Li Wen-Chao , Huang Jun , Deng Shu-Bo , Wang Yu-Jue , Yu Gang 
Published: November 2016

AbstractVarious per- and poly-fluorinated compounds (PFCs) were first systematically investigated in North Canal Basin, Beijing, China. A total of 68 surface water samples were collected from North Canal Basin, Beijing, at high spatial resolution. The seasonal disparity was compared and associated with source variation. PFCs concentrations in low-water period ranged from 26 to 207 ng/L, and significantly declined levels were found in high-water period. The individual component proportions among different sites varied less in high-water period, when runoff played a role in mixing and diluting PFCs. A methodology combined with principal component analysis (PCA), heat map-hierarchical cluster analysis (HM-HCA), and correlation analysis were introduced to discriminate sources of PFCs in surface water. The statistical results agreed with each other, and daily domestic consumption, fire-fighting products and related industries were identified as sources of PFCs in this region. In addition, two composition ratios were proposed through the methodology to distinguish the impact of nonpoint source, and the outcome demonstrates that great disparities exist in compositional profiles between nonpoint source and others. Overall, the results showed that this comprehensive analysis method has great potential for source apportionment in surface water and other environmental compartments.