bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Nickel Confined in the Interlayer Region of Birnessite: An Active Electrocatalyst for Water Oxidation.
Authors: Strongin Daniel R. , et al.  
Published: October 2016

AbstractNickel intercalated birnessite is prepared by ion exchange using an aqueous solution containing NiCl2, N2H4, and synthetic birnessite (10—30 min).
ChemInform Abstract: High‐Throughput Computational Screening of Perovskites for Thermochemical Water Splitting Applications.
Authors: Emery Antoine A. , Saal James E. , Kirklin Scott , Hegde Vinay I. , Wolverton Chris 
Published: October 2016

AbstractDFT calculations identify 139 ABO3 perovskite materials as potential new candidates for thermochemical water splitting applications.
ChemInform Abstract: Elemental Bromine Production by TiO2 Photocatalysis and/or Ozonation.
Authors: Parrino Francesco , Camera Roda Giovanni , Loddo Vittorio , Palmisano Leonardo 
Published: October 2016

AbstractFormation of Br2 occurs when a TiO2 aqueous suspension containing KBr and HNO3 is irradiated under near‐UV light in the presence of O2 (40 °C).
ChemInform Abstract: Direct Conjugate Alkylation of α,β‐Unsaturated Carbonyls by TiIII‐Catalyzed Reductive Umpolung of Simple Activated Alkenes.
Authors: Bichovski Plamen , Haas Thomas M. , Keller Manfred , Streuff Jan 
Published: October 2016

AbstractThe development and scope of the titanium(III)‐catalyzed cross‐selective reductive umpolung of Michael‐acceptors is presented.
ChemInform Abstract: Ir(III)‐Catalyzed Carbenoid Functionalization of Benzamides: Synthesis of N‐Methoxyisoquinolinediones and N‐Methoxyisoquinolinones.
Authors: Phatake Ravindra S. , Patel Pitambar , Ramana Chepuri V. 
Published: October 2016

AbstractDiazotized Meldrum′s acid and various other α‐diazocarbonyl compounds are employed for the carbenoid functionalization of benzamides, heterocyclic amides and aroylamides to give isoquinolinediones, isoquinolinones, and pyridones.
ChemInform Abstract: Aryl—Allene Cyclization via a Hg(OTf)2‐Catalytic Pathway.
Authors: Yamamoto Hirofumi , Ueda Maho , Yamasaki Naoto , Fujii Akiyoshi , Sasaki Ikuo , Igawa Kazunobu , Kasai Yusuke , Imagawa Hiroshi , Nishizawa Mugio 
Published: October 2016

AbstractA novel Hg(OTf)2‐catalyzed cyclization of 1,1‐disubstituted allenes bearing a tethered electron‐rich arene substituent is developed to give products having a quarternary vinyl substituted carbon center.
ChemInform Abstract: Synthesis of Furo[3,2‐c]coumarin Derivatives Using Visible‐Light‐Promoted Radical Alkyne Insertion with Bromocoumarins.
Authors: Zhou Hui , Deng Xinzhao , Ma Zhenjun , Zhang Aihua , Qin Qixue , Tan Ren Xiang , Yu Shouyun 
Published: October 2016

AbstractThe cytotoxicity of the products is examined, and three of the 17 prepared furo[3,2‐c]coumarins, 12 of which have previously not been reported, reveal a potent activity.
ChemInform Abstract: Iridium Catalysts with f‐Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones.
Authors: Wu Weilong , Liu Shaodong , Duan Meng , Tan Xuefeng , Chen Caiyou , Xie Yun , Lan Yu , Dong Xiu‐Qin , Zhang Xumu 
Published: October 2016

AbstractA series of tridentate ferrocene aminophosphoxazoline ligands like APX is synthesized and successfully applied to the asymmetric hydrogenation of ketones.
ChemInform Abstract: Synthesis of Coumarin Analogous of Decursivine Derivatives.
Authors: Shastri Samundeeswari , Chougala Bahubali , Holiyachi Megharaja , Shastri Lokesh , Hunnur Ravindra , Sunagar Vinay 
Published: October 2016

AbstractA five step protocol for the synthesis of two coumarin analogues of decursivine derivatives is described.
ChemInform Abstract: N‐Heterocyclic Olefins as Efficient Phase‐Transfer Catalysts for Base‐Promoted Alkylation Reactions.
Authors: Bluemel Marcus , Crocker Reece D. , Harper Jason B. , Enders Dieter , Nguyen Thanh V. 
Published: October 2016

AbstractThe novel application of N‐heterocyclic olefins (NHOs) as phase‐transfer organocatalysts for synthetically important alkylation reactions is developed.
ChemInform Abstract: N,N′‐Dioxide/Nickel(II)‐Catalyzed Asymmetric Diels—Alder Reaction of Cyclopentadiene with 2,3‐Dioxopyrrolidines and 2‐Alkenoyl Pyridines.
Authors: Lu Yan , Zhou Yuhang , Lin Lili , Zheng Haifeng , Fu Kai , Liu Xiaohua , Feng Xiaoming 
Published: October 2016

AbstractThe scalable procedure provides chiral bridged compounds in high yields and with very high diastereomeric and enantiomeric excesses.
ChemInform Abstract: Iodide‐Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates.
Authors: Mampuys Pieter , Zhu Yanping , Sergeyev Sergey , Ruijter Eelco , Orru Romano V. A. , Van Doorslaer Sabine , Maes Bert U. W. 
Published: October 2016

AbstractThis novel facile synthesis of S‐alkyl and S‐aryl thiocarbamates proceeds under mild conditions and tolerates a wide range of functional groups.
ChemInform Abstract: Transition‐Metal‐Free Synthesis of Homo‐ and Hetero‐1,2,4‐triaryl Benzenes by an Unexpected Base‐Promoted Dearylative Pathway.
Authors: Rehan Mohammad , Maity Sanjay , Morya Lalit Kumar , Pal Kaushik , Ghorai Prasanta 
Published: October 2016

AbstractAn unprecedented approach for the synthesis of homo‐ and heterotriaryl benzenes is developed by using a base‐mediated reaction of either α‐aryl cinnamyl alcohols or α,γ‐diaryl propanones.
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylation of Alkenes with Redox‐Neutral Remote Amidation of Aldehydes.
Authors: Cheng Cungui , Liu Shuiyou , Lu Danyang , Zhu Gangguo 
Published: October 2016

AbstractSubstrates containing aldehyde and alkene functionalities undergo trifluoromethylation and amidation under mild conditions in an one‐pot manner.
ChemInform Abstract: Synthesis of γ,δ‐Unsaturated α‐Aminoaldehydes Using a Copper‐Catalyzed Vinylation Reaction Followed by a Claisen Rearrangement.
Authors: Ricard Simon , Sanapo Gabriel F. , Rahem Neel , Daoust Benoit 
Published: October 2016

AbstractA high‐yielding copper‐catalyzed coupling reaction of β‐iodoenamides with various allylic is described which is applicable to the transformation of alkyl or aryl alcohols, albeit generally low product yields are obtained.
ChemInform Abstract: A Base‐Catalyzed, Domino Aldol/Hetero‐Diels—Alder Synthesis of Tricyclic Pyrano[3,4‐c]chromenes in Glycerol.
Authors: Parmar Bhagyashri D. , Sutariya Tushar R. , Brahmbhatt Gaurangkumar C. , Parmar Narsidas J. , Kant Rajni , Gupta Vivek K. 
Published: October 2016

AbstractThe exclusive formation of a single diastereoisomer is discussed on the basis of X‐ray and NMR data along with the isolation and characterization of the primary aldol condensation intermediate.
ChemInform Abstract: RhI‐Catalyzed Cyclizative Addition Reaction of 1,6‐Enyne and Sulfonyl Chloride by Carbophilic Activation.
Authors: Dang Mengyao , Hou Longlei , Tong Xiaofeng 
Published: October 2016

AbstractA broad spectrum of 1,6‐enyne substrates which include an N‐Tos or an oxygen function in the chain is treated with TosCl (II) and some analogues such as (XI) to produce highly functionalized sulfonylated pyridine or pyran structures bearing an unsaturated side chain.
ChemInform Abstract: A General, Effcient and Green Procedure for Synthesis of Dihydropyrimidine‐5‐carboxamides in Low Melting Betaine Hydrochloride/Urea Mixture.
Authors: Liu Peng , Hao Jianwu , Zhang Zhanhui 
Published: October 2016

AbstractA new, environment‐friendly protocol is described for the synthesis of dihydropyrimidine‐5‐carboxamides in a low‐melting deep eutectic solvent from a mixture of betaine hydrochloride with urea.
ChemInform Abstract: Tandem Synthesis of 10‐Dimethylaminobenzo[h]quinazolines from 2‐Ketimino‐1,8‐bis(dimethylamino)naphthalenes via Nucleophilic Replacement of the Unactivated Aromatic NMe2 Group.
Authors: Mikshiev Vladimir Y. , Antonov Alexander S. , Pozharskii Alexander F. 
Published: October 2016

AbstractThe lithiation of bis(dimethylamino)naphthalene derived ketimines and subsequent addition of aromatic and heteroaromatic nitriles results in a [2 + 2 + 2] cascade annulation to form benzo[h]quinazolines in moderate to good yields.
ChemInform Abstract: Divergent Synthesis of Quinazolin‐4(3H)‐ones and Tryptanthrins Enabled by a tert‐Butyl Hydroperoxide/K3PO4‐Promoted Oxidative Cyclization of Isatins at Room Temperature.
Authors: Jia Feng‐Cheng , Zhou Zhi‐Wen , Xu Cheng , Wu Yan‐Dong , Wu An‐Xin 
Published: October 2016

AbstractA facile synthesis of various functionalized quinazolinones from commercially available isatins and amidine hydrochlorides is presented.
ChemInform Abstract: A Formal Enantiospecific Synthesis of 7,20‐Diisocyanoadociane.
Authors: Roosen Philipp C. , Vanderwal Christopher D. 
Published: October 2016

AbstractA highly stereocontrolled synthesis of a late‐stage intermediate, the “Corey dione” (I), from which 7,20‐diisocyanoadociane (DICA) (II) is made, is reported.
ChemInform Abstract: Mn4+ Doped (NH4)2TiF6 and (NH4)2SiF6 Micro‐Crystal Phosphors: Synthesis Through Ion Exchange at Room Temperature and their Photoluminescence Properties.
Authors: Xi Luqing , Pan Yuexiao , Huang Shaoming , Liu Guokui 
Published: October 2016

AbstractIn view of a large scale industrial production, the title microcrystalline Mn4+‐doped phosphors are prepared by ion exchange of (NH4)2TiF6 or (NH4)2SiF6 (commercial products) with KMnO4 or K2MnF6 in aq.
SIMULATION OF IONOSPHERIC HEATING BASED ON SAMI2 MODEL
Authors: Xing MENG , Han‐Xian FANG , Li‐Bin WENG , Si‐Cheng WANG 
Published: October 2016

AbstractWith artificial heating term (Qhf) added in the electron energy equation of SAMI2 model, the disturbance amplitude of electron temperature and density along field line is simulated. The effects of disturbances under different heating conditions are also compared. The results show that the terrestrial ionospheric plasma can be heated by powerful high‐frequency radio waves, which can result in the rising of the temperature of electron in the whole field line, especially at the heated spot where electron temperature enhances more than 3 times; the pressure balance is broken as the increase in the electron temperature, which leads to plasma diffusion and then perturbation of electron density occurred; electron density gradient perpendicular to magnetic field line changes in accordance with the perturbation of electron density; the perturbation amplitude of electron temperature and density decreases during the heating time, which gradually becomes saturated. Electron temperature and density have a nonlinear relationship with the intensity of heating source.
MATCHED MULTI‐TRACE WEIGHTED RMS GEOMETRY REPEATABILITY FOR TIME‐LAPSE SEISMIC
Authors: Feng‐Shu DONG , Li‐Yun FU , Hai‐Yan QUAN , Ke‐Tong DONG , Xiu‐Yan XIN 
Published: October 2016

AbstractTime‐lapse, or 4D, seismic technology is a tool to monitor underground change for oil field maximum recovery or other purpose especially associated to human being activities. Repeatability is a key issue for time‐lapse seismic and geometry repeatability is a fundamental element to essentially affect the repeatability. There were many practices to improve repeatability during data processing, but geometry repeatability needs to be acquired during monitor data acquisition phase. Theory and practice shows that geometry repeatability determined in acquisition cannot be thoroughly improved in processing. Thus, geometry repeatability analysis is important. Multi‐trace geometry repeatability rises from practical situation. Multi‐trace geometry repeatability is important for overall geometry repeatability evaluation. The difference or repeatability of time‐lapse seismic data is evaluated by normalized RMS difference (NRMS). The definition of multi‐trace repeatability can be derived from NRMS for time‐lapse seismic/4D seismic data, showing that multi‐trace repeatability is weighted RMS of all single traces. Noting that the uncertainty of the match between monitor data and baseline data and that probable data size difference between monitor and baseline, the repeatability of the best baseline‐based match with imaginary data for mismatch was employed. Derived from previous researches, the linear model of relationship between seismic data repeatability and geometry repeatability was established, and the weighted RMS geometry repeatability of the best baseline‐based match with extrapolation for mismatch was obtained as the equivalent of the repeatability of the best baseline‐based match with imaginary data for mismatch. The weighting coefficient is determined on the basis of NMO and its stretch. Application study was also conducted based on real data to demonstrate that the new geometry repeatability can be utilized to valuate geometry repeatability during 4D monitor seismic data acquisition. The application study showed that one display of the multi‐trace geometry repeatability upon best baseline‐based match with extrapolation for mismatch can indicate repeatability and effect of fold of coverage simultaneously. The calculation in application was simplified for speed improvement, which is not yet the main point in this article.
Bone mineral density is associated with left ventricular diastolic function in women
Authors: Wang Rui‐tao , Li Xue‐song , Zhang Ji‐rong , Sun Yuxiang , Yu Kai‐jiang , Liu Tiemin 
Published: October 2016

BackgroundLow bone mineral density (BMD) and left ventricular (LV) diastolic function are associated with heart failure. However, little is known about the association between BMD and LV diastolic function.Hypothesis
BMD is independently related to LV diastolic function in women.MethodsWe conducted a cross‐sectional study of 432 women. Brachial‐ankle pulse wave velocity (baPWV) and BMD measurements were performed. LV diastolic function and structure were assessed by echocardiographic examination.Results
BaPWV and the percentage of LV diastolic dysfunction increased with progressive bone loss. Moreover, partial correlation analysis demonstrated that BMD at spine L2–4 and at femoral neck were correlated with baPWV and LV diastolic function parameters after adjusting covariates. Multivariate logistic regression analysis revealed that osteoporosis was independently associated with LV diastolic dysfunction in women.ConclusionsOsteoporosis is independently associated with LV diastolic dysfunction in women. A prospective study is needed to elucidate the effects of BMD on cardiac function in women.
Designing Simple Lipidated Lysines: Bifurcation Imparts Selective Antibacterial Activity
Authors: Ghosh Chandradhish , Konai Mohini Mohan , Sarkar Paramita , Samaddar Sandip , Haldar Jayanta 
Published: October 2016

AbstractIn the global effort to thwart antimicrobial resistance, lipopeptides are an important class of antimicrobial agents, especially against Gram‐negative infections. In an attempt to circumvent their synthetic complexities, we designed simple membrane‐active agents involving only one amino acid and two lipid tails. Herein we show that the use of two short lipid tails instead of a single long one significantly increases selective antibacterial activity. This study yielded several selective antibacterial compounds, and investigations into the properties of this compound class were conducted with the most active compound. Fluorescence spectroscopic studies revealed the capacity of the representative compound to cause depolarization and permeabilization of bacterial cell membranes. This membrane‐active nature of the compound imparts superior activity against persister cells, biofilms, and planktonic cells. Topical application of the compound decreased bacterial burden in mice inflicted with burn‐infections caused by Acinetobacter baumannii. We anticipate that the design principles described herein will direct the development of several antimicrobial agents of clinical importance.
An Enzyme‐Directed Imidazoquinoline for Cancer Immunotherapy
Authors: Hantho Joseph D. , Strayer Timothy A. , Nielsen Amy E. , Mancini Rock J. 
Published: October 2016

AbstractHerein we report the synthesis and activity of an enzyme‐directed immunostimulant with immune cell activation mediated by β‐galactosidase, either exogenously added, or on B16 melanoma cells. Covalent attachment of a β‐galactopyranoside to an imidazoquinoline immunostimulant at a position critical for activity resulted in a pro‐immunostimulant that could be selectively converted by β‐galactosidase into an active immunostimulant. The pro‐immunostimulant exhibited β‐galactosidase‐directed immune cell activation as measured by NF‐κB transcription in RAW‐Blue macrophages or cytokine production (TNF, IL‐6, IL‐12) in JAWSII monocytes. Conversion of the pro‐immunostimulant into an active immunostimulant was also found to occur using β‐galactosidase‐enriched B16 melanoma cells. In co‐culture experiments with either immune cell line, β‐galactosidase‐enriched B16 cells effected activation of bystander immune cells.
A phase 2 study of the sphingosine‐1‐phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma
Authors: Pal Sumanta K. , Drabkin Harry A. , Reeves James A. , Hainsworth John D. , Hazel Susan E. , Paggiarino Dario A. , Wojciak Jon , Woodnutt Gary , Bhatt Rupal S. 
Published: October 2016

BACKGROUNDUpregulation of sphingosine‐1‐phosphate (S1P) may mediate resistance to vascular endothelial growth factor (VEGF)‐directed therapies and inhibit antitumor immunity. Antagonism of S1P in preclinical models appears to overcome this resistance. In this phase 2 study, the authors assessed the activity of sonepcizumab, a first‐in‐class inhibitor of S1P, in patients with metastatic renal cell carcinoma (mRCC) with a history of prior VEGF‐directed therapy.METHODSPatients were required to have clear cell mRCC and to have received treatment with at least 1 prior VEGF‐directed agent. Prior treatment with immunotherapeutic agents and ≤1 mammalian target of rapamycin inhibitors was permitted. The primary endpoint of the study was progression‐free survival. Additional endpoints included response rate and safety, and overall survival (OS) performed post hoc.RESULTSA total of 40 patients were enrolled with a median of 3 prior therapies (range, 1‐5 prior therapies), 78% of whom had intermediate‐risk disease by second‐line International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria. Although the current study did not achieve its primary endpoint based on the 2‐month progression‐free survival, a median OS of 21.7 months was observed. Four patients (10%) demonstrated a partial response, with a median duration of response of 5.9 months. No grade 3/4 treatment‐related adverse events were observed in >5% of patients (adverse events were graded and recorded for each patient using Common Terminology Criteria for Adverse Events [version 4.0]); the most frequent grade 1/2 treatment‐related adverse events were fatigue (30%), weight gain (18%), constipation (15%), and nausea (15%). Biomarker studies demonstrated an increase in S1P concentrations with therapy. Comprehensive genomic profiling of 3 patients with a clinical benefit of >24 months indicated von Hippel–Lindau (VHL) and polybromo‐1 (PBRM1) alterations.CONCLUSIONSThe encouraging OS and favorable safety profile observed with sonepcizumab should prompt further investigation of the agent in combination with VEGF‐directed agents or checkpoint inhibitors. Cancer 2017;123:576–582. © 2016 American Cancer Society.
Aging analysis of a color facsimile binding for the 14th century manuscript “Registro Notarial de Torres”
Authors: López‐Montes Ana , Collado‐Montero Francisco José , Castillo Esther , Blanc Rosario , Campillo Domingo , Espejo Teresa 
Published: October 2016

AbstractThe re‐use of older documents or parts of books to make covers for archive documents has been common practice throughout the history of books. Such is the case with the 14th Century Registro Notarial de Torres, the binding of which is a fragment of a parchment belonging to a Visigothic codex of extreme historical value. In this work, it was decided that the parchment binding of the notarial register should be conserved as a separate document, replacing it with a color facsimile. The article discusses the accelerated aging tests to determine the stability of the materials used in producing the facsimile. Differences in color, pH, and ink transfer were evaluated. The original appearance of the manuscript was successfully retained using the optimum choice of materials, and the fragment of parchment used as its original binding was preserved, thus safeguarding its physical integrity and its aesthetic and artifactual value. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 474–485, 2017
Traffic scheduling for deep packet inspection in software‐defined networks
Authors: Huang Huawei , Li Peng , Guo Song 
Published: October 2016

SummaryDeep packet inspection (DPI) is important for network security. In this paper, we consider a software‐defined network where several DPI proxy nodes are available for serving flows from ingress switches. These DPI proxy nodes can be implemented in either software or hardware. We study an integrated proxy allocation and routing determining problem with the objective of minimizing the total delay of flows from ingress switches to DPI proxies. This problem is formulated as an integer linear programming problem that is NP‐hard in general. To solve this problem, we design a 2‐phase algorithm that can quickly select proxy and find routing paths for incoming flows. Finally, extensive simulations are conducted to evaluate the performance of our proposed algorithm. Some useful parameter setting insights are obtained.
Impulsive Collision Dynamics of CO Super Rotors from an Optical Centrifuge
Authors: Murray Matthew J. , Ogden Hannah M. , Toro Carlos , Liu Qingnan , Mullin Amy S. 
Published: October 2016

AbstractWe report state‐resolved collision dynamics for CO molecules prepared in an optical centrifuge and measured with high‐resolution transient IR absorption spectroscopy. Time‐resolved polarization‐sensitive measurements of excited CO molecules in the J=29 rotational state reveal that the oriented angular momentum of CO rotors is relaxed by impulsive collisions. The translational energy gains for molecules in the initial plane of rotation are threefold larger than for randomized angular momentum orientations, indicating the presence of anisotropic kinetic energy. The transient data show enhanced population for CO molecules in the initial plane of rotation immediately following the optical centrifuge pulse. A comparison with previous CO2 super rotor studies illustrates the behavior of molecular gyroscopes; spatial reorientation of CO2 J=76 rotors takes substantially longer than that for CO J=29 rotors, despite similarities in classical rotational period and rotational energy gap. High‐resolution transient IR absorption measurements of the CO J=29–39 rotational states show that the collisional depopulation rates increase with J quantum number.
Thermally Stable and Highly Luminescent Green Emissive Fluorophores with Acenaphtho[1,2‐k]fluoranthene Cores and Aromatic Amine Groups
Authors: Han Liang , Ye Kaiqi , Li Chenglong , Zhang Yuewei , Zhang Hongyu , Wang Yue 
Published: October 2016

AbstractFour acenaphtho[1,2‐k]fluoranthene‐cored fluorophores 1–4 attached by a variety of N‐containing electron‐donating groups have been designed and synthesized. The appending N‐containing moieties and the central acenaphtho[1,2‐k]fluoranthene core form twisted molecular configurations and lead to separated HOMO and LUMO frontier molecular orbitals. X‐ray crystallographic analysis demonstrates that the substituted aromatic amines separate the luminescent π‐conjugated cores in the solid state. These compounds display excellent thermal and amorphous stabilities, high solid‐state fluorescence quantum efficiencies, and ambipolar charge transporting properties, indicating that they are ideal candidates for fabricating non‐doped organic light‐emitting diodes (OLEDs). The device based on compound 4 exhibits the best electroluminescent performance with an external efficiency of 2.82 % and brightness of 45800 cd m−2, demonstrating the potential applications of this compound for OLED displays and lighting.