bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Control With the Bio-inspired Artificial Pancreas in Adults With Type 1 Diabetes
Authors: Reddy Monika , Herrero Pau , Sharkawy Mohamed El , Pesl Peter , Jugnee Narvada , Pavitt Darrell , Godsland Ian F. , Alberti George , Toumazou Christofer , Johnston Desmond G. , Georgiou Pantelis , Oliver Nick S. 
Published: November 2015

Background: The Bio-inspired Artificial Pancreas (BiAP) is a closed-loop insulin delivery system based on a mathematical model of beta-cell physiology and implemented in a microchip within a low-powered handheld device. We aimed to evaluate the safety and efficacy of the BiAP over 24 hours, followed by a substudy assessing the safety of the algorithm without and with partial meal announcement. Changes in lactate and 3-hydroxybutyrate concentrations were investigated for the first time during closed-loop. Methods: This is a prospective randomized controlled open-label crossover study. Participants were randomly assigned to attend either a 24-hour closed-loop visit connected to the BiAP system or a 24-hour open-loop visit (standard insulin pump therapy). The primary outcome was percentage time spent in target range (3.9-10 mmol/l) measured by sensor glucose. Secondary outcomes included percentage time in hypoglycemia (<3.9 mmol/l) and hyperglycemia (>10 mmol/l). Participants were invited to attend for an additional visit to assess the BiAP without and with partial meal announcements. Results: A total of 12 adults with type 1 diabetes completed the study (58% female, mean [SD] age 45 [10] years, BMI 25 [4] kg/m2, duration of diabetes 22 [12] years and HbA1c 7.4 [0.7]% [58 (8) mmol/mol]). The median (IQR) percentage time in target did not differ between closed-loop and open-loop (71% vs 66.9%, P = .9). Closed-loop reduced time spent in hypoglycemia from 17.9% to 3.0% ( P < .01), but increased time was spent in hyperglycemia (10% vs 28.9%, P = .01). The percentage time in target was higher when all meals were announced during closed-loop compared to no or partial meal announcement (65.7% [53.6-80.5] vs 45.5% [38.2-68.3], P = .12). Conclusions: The BiAP is safe and achieved equivalent time in target as measured by sensor glucose, with improvement in hypoglycemia, when compared to standard pump therapy.
Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid
Authors: Verhagen Han J. M. P. , Smit Marjon A. , Rutten Arjo , Denkers Fedor , Poddighe Pino J. , Merle Pauline A. , Ossenkoppele Gert J. , Smit Linda 
Published: November 2015

Key Points
EVI-1–positive AML cases are sensitive to ATRA.
Complete genome sequence of Thioalkalivibrio paradoxus type strain ARh 1T, an obligately chemolithoautotrophic haloalkaliphilic sulfur-oxidizing bacterium isolated from a Kenyan soda lake
Authors: Berben Tom , Sorokin Dimitry Y. , Ivanova Natalia , Pati Amrita , Kyrpides Nikos , Goodwin Lynne A. , Woyke Tanja , Muyzer Gerard 
Published: November 2015

AbstractThioalkalivibrio paradoxus strain ARh 1T is a chemolithoautotrophic, non-motile, Gram-negative bacterium belonging to the Gammaproteobacteria that was isolated from samples of haloalkaline soda lakes. It derives energy from the oxidation of reduced sulfur compounds and is notable for its ability to grow on thiocyanate as its sole source of electrons, sulfur and nitrogen. The full genome consists of 3,756,729 bp and comprises 3,500 protein-coding and 57 RNA-coding genes. This organism was sequenced as part of the community science program at the DOE Joint Genome Institute.
Annotation inconsistencies beyond sequence similarity-based function prediction – phylogeny and genome structure
Authors: Promponas Vasilis J. , Iliopoulos Ioannis , Ouzounis Christos A. 
Published: November 2015

AbstractThe function annotation process in computational biology has increasingly shifted from the traditional characterization of individual biochemical roles of protein molecules to the system-wide detection of entire metabolic pathways and genomic structures. The so-called genome-aware methods broaden misannotation inconsistencies in genome sequences beyond protein function assignments, encompassing phylogenetic anomalies and artifactual genomic regions. We outline three categories of error propagation in databases by providing striking examples – at various levels of appreciation by the community from traditional to emerging, thus raising awareness for future solutions.
Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization
Authors: Kumar Sujeet , Parameswaran Sreejit , Sharma Rajendra K. 
Published: November 2015

ABSTRACT
The hexokinase 1 variant in mammalian spermatozoa (HK1S) has a unique N-terminus and this isoform atypically localizes to the plasma membrane. However, the mechanism of this process currently remains ambiguous. In this report, we show that fatty acylation underlies the specific sorting of HK1S. Employing chimeric reporter constructs, we first established that compartmentalization of HK1S does not function exclusively in sperm cells and that this feature is swappable to somatic HEK293 cells. Although the N-terminus lacks the classical consensus signature for myristoylation and the sequence-based predictions fail to predict myristoylation of HK1S, complementary experimental approaches confirmed that HK1S is myristoylated. Using live-cell confocal microscopy, we show that the mutation of a single amino acid, the myristoyl recipient Gly2, impedes the prominent feature of plasma membrane association and relocates the enzyme to the cytosol but not the nucleus. Additionally, substitutions of the putatively palmitoylated Cys5 is also reflected in a similar loss of compartmentalization of the protein. Taken together, our findings conclusively demonstrate that the N-terminal ‘MGQICQ’ motif in the unique GCS domain of HK1S acquires hydrophobicity by dual lipidic modifications, N-myristoylation and palmitoylation, to serve the requirements for membranous associations and thus its compartmentalization.
Cd(II) Capture Ability of an Immobilized, Fluorescent Hexapeptide
Authors: Galbács Gábor , Szokolai Hajnalka , Kormányos Attila , Metzinger Anikó , Szekeres Levente , Marcu Claudiu , Peter Francisc , Muntean Cornelia , Negrea Adina , Ciopec Mihaela , Jancsó Attila 
Published: November 2015

Abstract
A novel, cysteine-containing fluorescent hexapeptide, N-acetyl-Tyr-Cys-Ser-Ser-Cys-Tyr– (YY), targeting Cd(II) ion sensing, was synthesized on various solid supports including two resins, as well as glass and quartz surfaces. The synthesis was based on the Fmoc (9-fluorenylmethoxycarbonyl) and the APTES (3-aminopropyltriethoxysilane) methodologies on the resin and silica supports, respectively. The immobilized ligand, except when coupled to a hydrophobic benzhydrylamine resin, showed a remarkably efficient, pH-dependent Cd(II) capturing ability with a maximum binding capacity around neutral pH. The effect of contact time and metal ion concentration was also studied with a hydrophilic resin supported peptide (YY-NTG). The interaction of YY-NTG with Cd(II) was investigated by pH-potentiometric titrations in aqueous samples containing the resin beads and Cd(II). These studies, together with metal ion capturing experiments under buffer-controlled pH, prove that each immobilized peptide can bind one Cd(II) ion at pH 7.0 in the presence of one equivalent metal ion or metal ion excess. For Cd(II) binding to YY-NTG a notably high, K = 1.3 × 1010 apparent stability constant was determined (1:1 metal-to-ligand ratio, pH 7.0). Analytical results suggest that the concentration of Cd(II) can be measured below 200 nM with this silica-supported peptide. The usefulness of the probe was demonstrated by fluorescence spectroscopy.
Control of Photocleavage Reaction by Intramolecular Hydrogen Bonding in (3-Benzoxazolyl-2-hydroxy-5-methylphenyl)methyl Acetate
Authors: Honda Takuya , Arai Tatsuo 
Published: November 2015

Abstract
2-Hydroxyphenylpyridine and 2-hydroxyphenylbenzoxazole derivatives were synthesized and their photochemical properties were investigated. The results indicated that photocleavage reaction was controlled by intramolecular hydrogen bond.
Implementing evidence-based enteral nutrition guidelines in intensive care units: a prospective observational study
Authors: Kalaldeh Mahmoud Al , Shahin Mahmoud 
Published: November 2015

Aim To evaluate the impact of evidence-based enteral nutrition (EN) guidelines on nutritional outcomes in critically ill, mechanically ventilated patients. Methods A prospective observational study included an introductory programme for nurses on recent American Society for Parenteral and Enteral Nutrition (ASPEN) nurse-centered guidelines on EN. Bedside observations pre and post-intervention included clinical outcomes, nutritional adequacy, and EN-associated complications. Results A total of 192 patients (80 controls,112 intervention patients) participated. Following implementation of the guidelines, the most significant clinical outcomes included a reduction in gastric residual volume (P=0.001) and change in body weight (P=0.032). Calorie adequacy increased from 8.7% to 55.4% (P<0.001). The incidence of pulmonary aspiration and diarrhoea reduced significantly (P=0.03, P<0.001 respectively). Gender, duration of EN, duration of mechanical ventilation, and acute physiology and chronic health evaluation (APACHE) II score were factors influencing nutritional adequacy. Conclusion Adopting ASPEN guidelines improves nutritional adequacy and clinical outcomes in enterally fed, mechanically ventilated patients.
Savage sexism: Examining gendered intelligence in Hulk and She-Hulk comics
Authors: Settoducato Elizabeth 
Published: November 2015

Abstract
By using Hulk and She-Hulk comics from the 1980s as subjects for a case study, this article explores the seemingly lost potential of She-Hulk’s intelligence and exposes the problematic depictions of female superheroes as seen in her comics. This article pushes back against the practice of citing fans and their preferences as rationale for the troubling depictions of gendered bodies that so often characterize superhero comics (especially in a context of the 1980s cult of fitness), and examines not only these gendered representations, but also the gender differences in comics readership. In looking for alternatives to and subversive moments against these gendered social messages, this article also discusses the extent to which intelligence can be read as a sexually neutralizing element for Bruce Banner (Hulk) and his cousin Jennifer Walters (She-Hulk). Ultimately, it seems that, at least in the 1980s, attempts at smashing the status quo were countered by the stereotypical sexism produced and perpetuated by patriarchy.
Towards a contingencybased approach to value for community radio
Authors: Order Simon 
Published: November 2015

Abstract
Community radio in Australia is now well established and considered an important part of the radio sector, however, in today’s economically driven world it is at the bottom of the media money pile. In order to argue for its continuing existence, funding and development in an ever-changing media landscape, some means of capturing its value is essential. This article describes the development of a theoretical framework of value for community radio. The content of the framework was achieved by, first, examining, community media/radio literature through five relevant lenses of analysis. Secondly, a subsequent meta-analysis was applied to consolidate the framework. In order to test the utility of the draft theoretical framework of value, three case studies were conducted with different types of community radio stations in Perth, Western Australia. Two primary research methods were used: interviews with staff and audience focus groups. The testing exercise provided a multimodal insight into the values of community radio as reflected in real life practice. The analysis revealed how value was perceived by participants across three stations as personal motivations, and second, that value at individual stations was contingent upon the characteristics of the individual community radio stations.
Contemporary Christian radio in Britain: A new genre on the national dial
Authors: Cooper Martin , Macaulay Kirsty 
Published: November 2015

Abstract
Only in the second decade of the twenty-first century has contemporary Christian radio appeared as a new genre in Britain, unlike the United States where it has long been a significant format. Responsibility for religious broadcasting in the United Kingdom was, for most of the twentieth century, fulfilled by the BBC. However, the gradual relaxation of broadcasting regulations since the 1980s and the introduction of Digital Audio Broadcasting (DAB) have provided openings for Christian radio stations, and since 2009 the United Kingdom has had two national stations broadcasting from mainland studios for the first time. This article explores recent developments in this genre, using primary research interviews with Christian radio broadcasters. It suggests that what started out as a way for Christians to evangelize and proselytize their message has become a radio service that broadcasts almost exclusively to converted believers. It also observes that the programming and scheduling of these stations closely resembles the speech-and-music-mix style of BBC Local Radio, implying an attempt to insert themselves directly into the mainstream of the radio spectrum.
The production context of the Zeng State bronzes from Yejiashan Cemetery of the Western Zhou Dynasty
Authors: Zhang Changping 
Published: November 2015

AbstractIn 2011 and 2013, 65 Western Zhou tombs of the Zeng State were excavated at the Yejiashan Cemetery in Suizhou City, Hubei Province. Among them, M1, M28 and M27 and M65 and M2 are the tombs of the earliest three generations of rulers and spouses of the early Western Zhou Dynasty. The bronzes unearthed from the Yejiashan Cemetery exhibit not only the characteristics of the common Western Zhou style in typological morphology and assemblage, but also local features reflecting local production. In the technical sense, the bronzes from the Yejiashan Cemetery bear special traits in modeling and molding details: some are of the style other than that of the Zhou, and others are imitations of the same type of bronzes. The characteristics of the bronzes of the Zeng State indicate that in the early Western Zhou Dynasty, the Zeng State has the capability of producing bronzes as it does during the transitional period from the Western Zhou through the Eastern Zhou Period.
Lust, die glücklich macht
Authors: Espinet David 
Published: November 2015

Abstract
Against the still prevalent assumption according to which Kant’s moral philosophy does not, at least for sensuous rational agents, provide a satisfactory answer to the problem posed by their need of happiness, the present paper develops the following argument: The subject must be able to interrupt her pursuit of happiness - precisely in order not to game away her happiness. Within the horizon of Kant’s doctrine of moral incentives as well as in a secular reading of his conception of the highest good, one can see, first, that the possibility of a morally motivated interruption of the pursuit of happiness is a necessary condition precisely for the happiness of finite but rational agents; second, that sensuous satisfaction must be understood as an integrative component of the highest good and, as such, as a second necessary condition for happiness. Kant’s notion of the highest good, thus, conceptualizes the coincidence of virtue and lust as a sufficient condition of happiness, by which a morally mediated lust becomes possible that not only provides sensuous satisfaction, but also makes us happy.
The Structural Device of “Unsuccessful Repetition” in Two Ancient Greek Healing Narratives
Authors: Fariñas Óscar M. Bernao 
Published: November 2015

AbstractSince the turn of the nineteenth into the twentieth century scholars have underscored the similarities between two ancient Greek healing accounts of miraculous cures ascribed to Asclepius, the Greek god of Medicine, and some modern narratives related to the international folktale known as ATU 753 A: Unsuccessful Repetition. This study analyses the narrative structure of these accounts in order to reassess the similarities pointed out by earlier researchers and also enquires into some compositional aspects of one of these narratives.
Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity
Authors: Olombrada Miriam , García-Ortega Lucía , Lacadena Javier , Oñaderra Mercedes , Gavilanes José G. , Martínez-del-Pozo Álvaro 
Published: November 2015

AbstractRibotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including the geometric arrangement of their active sites. However, ribotoxins are larger, with a well-defined N-terminal β-hairpin, and display longer and positively charged unstructured loops. These structural differences account for their cytotoxic properties. Unexpectedly, the discovery of hirsutellin A (HtA), a ribotoxin produced by the invertebrate pathogenHirsutella thompsonii, showed how it was possible to accommodate these features into a shorter amino acid sequence. Examination of HtA N-terminal β-hairpin reveals differences in terms of length, charge, and spatial distribution. Consequently, four different HtA mutants were prepared and characterized. One of them was the result of deleting this hairpin [Δ(8-15)] while the other three affected single Lys residues in its close spatial proximity (K115E, K118E, and K123E). The results obtained support the general conclusion that HtA active site would show a high degree of plasticity, being able to accommodate electrostatic and structural changes not suitable for the other previously known larger ribotoxins, as the variants described here only presented small differences in terms of ribonucleolytic activity and cytotoxicity against cultured insect cells.
Grautöne: Verleger und Zensurregime in Mitteleuropa 1800–1850
Authors: Brophy James M. 
Published: November 2015

Zusammenfassung
Das Ausmaß der staatlichen Intervention in Deutschlands Öffentlichkeit im frühen 19. Jahrhundert war erheblich. Die Korrespondenzen, Tagebücher oder andere Egodokumente der Intellektuellen geben dem Historiker eine Fülle von vorzüglichem Quellenmaterial an die Hand, um deren Rhetorik und Kritik herauszuarbeiten. Allerdings verblasst hinter jenen Textquellen die erstaunliche Leistung der Verleger, diese Texte als Drucke zu publizieren und zu verbreiten. Dieser Beitrag lenkt nun den Fokus auf jene Verleger und deren Auseinandersetzung mit der Zensur und modifiziert dabei die herkömmliche Interpretation. Anhand von Fallstudien aus Preußen, Sachsen und dem Deutschen Bund bildet die Studie den Umgang deutscher Verleger mit der Zensur ab, deren Aufgabe in einer sogenannten „Torhüterfunktion“ für eine staatlich sanktionierte Öffentlichkeit bestand. Trotz mancherlei Rückschlägen trugen die Verleger dazu bei, die neoabsolutistisch geprägte politische Öffentlichkeit aufzubrechen und eine neue, diskursive Qualität der politischen Kommunikation zu erreichen. Dabei verschafften die Dynamik einer liberalen Marktwirtschaft sowie das bürgerliche Rechtssystem, das Bücher als Ware und Privateigentum schützte, den Verlegern gewisse strategische Vorteile. Darüber hinaus gab es durchaus auch Zensoren, die mit Verlegern und Autoren mehr oder weniger informell kooperierten, um kontroverse Texte zu verlegen. Wenn man die auf diesem Wege erzielte beachtliche Verbreitung verbotener Schriften berücksichtigt, muss die Wirkung staatlicher Kontrolle neu eingeschätzt werden. Auf dieser revidierten Grundlage können somit auch der Transfer und die Verflechtung politischer Kompetenzen in West- und Mitteleuropa besser eingeordnet werden.
Un manuscrit mesconnëu de l’Estoire del Saint Graal: Bourg-en-Bresse, Médiathèque Vailland 55. Le programme paratextuel
Authors: Chase Carol J. 
Published: November 2015

Abstract:
Bourg-en-Bresse, Médiathèque Vailland MS 55, which contains a copy of the Estoire del Saint Graal dated in the 1330s, is not very well known, for two reasons. First, the version of the text that it conserves is mixed; second, the codex is mutilated. Nevertheless, this witness deserves our attention, because a number of the rubrics have survived, as have some of the miniatures. The latter were realized by an artist working in Paris, known as the Master of the Vies de Saint Louis, or Mahiet. This article has a double goal: to present the manuscript and to study the rubrics and miniatures in order to explore their role and their relationship with the text and with other codices containing the Estoire del Saint Graal. A description of the manuscript is followed by a study of the paratextual programme; the article concludes with a section on the manuscript tradition.
The case of the ‘curious document’: Thomas Malory, William Matthews and Eugène Vinaver
Authors: Rayner Samantha 
Published: November 2015

Abstract:
This article looks at the publication history of Eugène Vinaver’s Works of Sir Thomas Malory, examining letters and documents located in the Oxford University Press archive and exploring the part that correspondence between William Matthews and Press representatives played in the production of the Second Edition of 1967. These correspondences also expose new contexts for what has come to be known as ‘the Malory Debate’, after a book of the same name edited by Bonnie Wheeler, Robert L. Kindrick and Michael N. Salda (Cambridge: Brewer, 2000). The article uses the cultural production theories of Pierre Bourdieu to emphasise the important, but often hidden, part that publishers play in the development of scholarly texts and debates, helping to shape disciplinary fields and ensure a rigorous framework within which they can evolve and mature.
Learning the Condition of Satisfaction of an Elementary Behavior in Dynamic Field Theory
Authors: Luciw Matthew , Kazerounian Sohrob , Lahkman Konstantin , Richter Mathis , Sandamirskaya Yulia 
Published: November 2015

AbstractIn order to proceed along an action sequence, an autonomous agent has to recognize that the intended final condition of the previous action has been achieved. In previous work, we have shown how a sequence of actions can be generated by an embodied agent using a neural-dynamic architecture for behavioral organization, in which each action has an intention and condition of satisfaction. These components are represented by dynamic neural fields, and are coupled to motors and sensors of the robotic agent.Here,we demonstratehowthemappings between intended actions and their resulting conditions may be learned, rather than pre-wired.We use reward-gated associative learning, in which, over many instances of externally validated goal achievement, the conditions that are expected to result with goal achievement are learned. After learning, the external reward is not needed to recognize that the expected outcome has been achieved. This method was implemented, using dynamic neural fields, and tested on a real-world E-Puck mobile robot and a simulated NAO humanoid robot.