bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous squamous cell carcinoma of the lip: A population‐based analysis
Authors: Unsal Aykut A. , Unsal Aylin B. , Henn Tara E. , Baredes Soly , Eloy Jean Anderson 
Published: June 2017

Objectives/HypothesisThe role of cumulative ultraviolet (UV) radiation in cutaneous squamous cell carcinoma of the lip (CSCCL) is well understood. This study seeks to evaluate overall survival as well as incidence and demographics across geographic regions, given differences in UV exposure across the United States.Study DesignRetrospective population‐based analysis.MethodsA total of 14,901 CSCCL cases were identified as being from the West, Midwest, South, or Northeast, utilizing the Surveillance, Epidemiology, and End Results registry from 1973 to 2013. Demographics, stage of disease, and treatment modalities were compared among regions.ResultsOf the CSCCL cases reported, 58.3%, 24.5%, 10.8%, and 6.4% originated from the West, Midwest, South, and Northeast, respectively. Patients most commonly presented with T1 tumors (81.3%), and nodal and distant metastasis was rare for patients from all regions (3.1% and 0.3%, respectively). Patients with American Joint Committee on Cancer stage II and higher were most likely from the Northeast or South. Overall, most patients were treated with surgery monotherapy (89.5%); however, surgical monotherapy was least commonly utilized in patients in the Northeast and South. Overall 5‐year disease specific survival was measured at 94.7%.ConclusionAlthough areas of high UV index are implicated in increased morbidity and mortality due to CSCCL, this study indicates that a variety of factors play a role in CSCCL incidence and outcomes in the United States. The elderly and non‐white populations were identified as poor prognostic demographic factors. Investigation detailing differences in CSCCL detection and treatment may aid in the identification of higher‐risk populations.Level of Evidence4. Laryngoscope, 128:84–90, 2018
An evaluation of potentiometric pH sensors in coastal monitoring applications
Authors: McLaughlin Karen , Nezlin Nikolay P. , Weisberg Stephen B. , Dickson Andrew G. , Booth J. Ashley , Cash Curtis L. , Feit Adriano , Gully Joseph R. , Johnson Scott , Latker Ami , Mengel Michael J. , Robertson George L. , Steele Alex , Terriquez Laura 
Published: June 2017

AbstractA wealth of historical coastal water pH data has been collected using potentiometric glass electrodes, but the accuracy and stability of these sensors is poorly understood. Here we compared pH measurements from five potentiometric sensors incorporated into profiling Sea‐Bird instrument packages and compared them to spectrophotometric measurements on discrete bottle samples collected at two to three depths associated with each cast. Differences ranged from −0.509 to +0.479 with a mean difference of −0.055 pH units. Ninety‐two percent of the measurements were within ± 0.2 pH units, but 1% of the measurements had differences greater than 0.322. Sensor performance was affected by depth, but most of the difference was associated with calibration shortcomings. Sensor drift within a day was negligible; moreover, differences between bottle samples and electrode measurements within a sampling day were smaller than differences across days. Bootstrap analysis indicated that conducting a daily in situ calibration would reduce the mean difference to 0.002 pH units and increase the number of samples within a 0.2 pH unit error to 98%.
Boosting the SNR by adding a receive‐only endorectal monopole to an external antenna array for high‐resolution, T2‐weighted imaging of early‐stage cervical cancer with 7‐T MRI
Authors: van Kalleveen I.M.L. , Hoogendam J.P. , Raaijmakers A.J.E. , Visser F. , Arteaga de Castro C.S. , Verheijen R.H.M. , Luijten P.R. , Zweemer R.P. , Veldhuis W.B. , Klomp D.W.J. 
Published: June 2017

The aim of this study was to investigate the signal‐to‐noise ratio (SNR) gain in early‐stage cervical cancer at ultrahigh‐field MRI (e.g. 7 T) using a combination of multiple external antennas and a single endorectal antenna. In particular, we used an endorectal monopole antenna to increase the SNR in cervical magnetic resonance imaging (MRI). This should allow high‐resolution, T2‐weighted imaging and magnetic resonance spectroscopy (MRS) for metabolic staging, which could facilitate the local tumor status assessment. In a prospective feasibility study, five healthy female volunteers and six patients with histologically proven stage IB1–IIB cervical cancer were scanned at 7 T. We used seven external fractionated dipole antennas for transmit–receive (transceive) and an endorectally placed monopole antenna for reception only. A region of interest, containing both normal cervix and tumor tissue, was selected for the SNR measurement. Separated signal and noise measurements were obtained in the region of the cervix for each element and in the near field of the monopole antenna (radius < 30 mm) to calculate the SNR gain of the endorectal antenna in each patient. We obtained high‐resolution, T2‐weighted images with a voxel size of 0.7 × 0.8 × 3.0 mm3. In four cases with optimal placement of the endorectal antenna (verified on the T2‐weighted images), a mean gain of 2.2 in SNR was obtained at the overall cervix and tumor tissue area. Within a radius of 30 mm from the monopole antenna, a mean SNR gain of 3.7 was achieved in the four optimal cases. Overlap between the two different regions of the SNR calculations was around 24%. We have demonstrated that the use of an endorectal monopole antenna substantially increases the SNR of 7‐T MRI at the cervical anatomy. Combined with the intrinsically high SNR of ultrahigh‐field MRI, this gain may be employed to obtain metabolic information using MRS and to enhance spatial resolutions to assess tumor invasion.
Association between consistent weight gain tracking and gestational weight gain: Secondary analysis of a randomized trial
Authors: Olson Christine M. , Strawderman Myla S. , Graham Meredith L. 
Published: June 2017

ObjectiveThe effective components of interventions for reducing excessive gestational weight gain (GWG) remain to be identified. This study investigated the sociodemographic, physical, psychosocial, and environmental correlates of online GWG tracking and its independent association with GWG outcomes.MethodsEight hundred ninety‐eight women in the intervention arms of a randomized trial assessing the effectiveness of an integrated online and mobile phone behavioral intervention to decrease the prevalence of excessive GWG were included in this secondary analysis. Data were analyzed using χ2 analysis and modified Poisson and linear regression approaches.ResultsOnly 16.5% of low‐income (Medicaid‐eligible) women consistently tracked GWG, as did 34.2% of not‐low‐income women. More highly educated, older, and white women were more likely to be consistent GWG trackers. Among not‐low‐income women, consistent GWG tracking was associated with 2.35 kg less GWG (95% CI: −3.23 to −1.46 kg; P < 0.0001) and a reduced risk of excessive GWG (RR 0.73; 95% CI: 0.59 to 0.89; P = 0.002).ConclusionsElectronic tracking of GWG is an effective component of electronic and mobile health interventions aiming to decrease the prevalence of excessive GWG in not‐low‐income women. Income group‐specific motivators are needed to increase the prevalence of GWG tracking.
Synthesis of glycopeptides from glucosaminic acid
Authors: Abtew Ester , Domb Abraham J. , Basu Arijit 
Published: June 2017

ABSTRACTWe report on the synthesis of polypeptides with saccharide side chains starting from d‐glucosaminic acid. The hydroxyl groups were first protected by benzylation, followed by N‐carboxyanhydride formation, which was polymerized by ring opening to form a high molecular weight polyamide. De‐protection of the benzyl groups yields a polypeptide with fully de‐protected saccharide side chains. The resulting new non‐ionic, water soluble, and optically active polymers possessing the properties of both peptides and saccharides have potential use as scaffolds for tissue engineering and drug carriers. The method described here may be extended to any saccharide α‐amino acid. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2657–2662
Periprostatic innervation: New issues based on segmental analysis of 10 human cadaver pelvic blocs
Authors: Rodrigues Tiago M. , Mitre Anuar I. , da Silva Luiz Fernando F. , Castilho Lísias N. , Simões Fabiano A. , Saldiva Paulo H. N. , Srougi Miguel 
Published: June 2017

BackgroundThe exact paths of periprostatic nerves have been under debate over the last decades. In the present study, the topographic distribution of nerves around the prostate and their relative distances from the prostatic capsule were analyzed in male cadaver visceral blocs.MethodsThe pelvic organs from ten fresh male cadavers were removed and serial sectioned en bloc for histological investigation. The macroslices was divided into four sectors. Each sector was centrally covered with a raster dividing each sector in three subsectors numbered clockwise. The prostatic capsule was identified, and distances of 2.5 and 5 mm from the prostate were demarked with lines. We quantified the number of nerve fibers present in each subsector of each slide and recorded their position relative to the prostatic capsule.ResultsIn general, the topographic analysis revealed that the majority of nerves were identified in sectors 4 through 9, corresponding to the posterolateral and posterior surfaces of the prostate gland. At the prostate base, the majority of nerves were found at the posterolateral and posterior surfaces of the gland. Within the mid‐region of the prostate, the same topographic distribution pattern was observed, but the nerve fibers were closer to the prostatic capsule. At the apical region, the percentage of nerve fibers identified in the anterior region was higher, despite their major concetration in the posterior surface. The nerves identified at the apex were mainly located up to 2.5 mm from the prostate. This proximity to the prostate was specifically observed in the anterolateral and anterior sectors. In the craniocaudal sense, the percentage of nerves identified between 2.5 and 5 mm from the prostatic capsule remained constant.ConclusionsA significant number of nerve fibers were present in the anterior and anterolateral positions, especially at the apex. The anterior nerves were closer to the prostate. This proximity suggests that the anterior nerves may participate in local physiology and that the cavernous nerves are probably formed by the posterior nerve fibers. It is likely that the safe distance of 2.5 mm from all surfaces of the prostate may be related to cavernous fiber preservation.
Mono-, bi-, and tri-metallic Ni-based catalysts for the catalytic hydrotreatment of pyrolysis liquids
Authors: Yin Wang , Venderbosch Robbie H. , He Songbo , Bykova Maria V. , Khromova Sofia A. , Yakovlev Vadim A. , Heeres Hero J. 
Published: June 2017

AbstractCatalytic hydrotreatment is a promising technology to convert pyrolysis liquids into intermediates with improved properties. Here, we report a catalyst screening study on the catalytic hydrotreatment of pyrolysis liquids using bi- and tri-metallic nickel-based catalysts in a batch autoclave (initial hydrogen pressure of 140 bar, 350 °C, 4 h). The catalysts are characterized by a high nickel metal loading (41 to 57 wt%), promoted by Cu, Pd, Mo, and/or combination thereof, in a SiO2, SiO2-ZrO2, or SiO2-Al2O3 matrix. The hydrotreatment results were compared with a benchmark Ru/C catalyst. The results revealed that the monometallic Ni catalyst is the least active and that particularly the use of Mo as the promoter is favored when considering activity and product properties. For Mo promotion, a product oil with improved properties viz. the highest H/C molar ratio and the lowest coking tendency was obtained. A drawback when using Mo as the promoter is the relatively high methane yield, which is close to that for Ru/C. 1H, 13C-NMR, heteronuclear single quantum coherence (HSQC), and two-dimensional gas chromatography (GC × GC) of the product oils reveal that representative component classes of the sugar fraction of pyrolysis liquids like carbonyl compounds (aldehydes and ketones and carbohydrates) are converted to a large extent. The pyrolytic lignin fraction is less reactive, though some degree of hydrocracking is observed.
Do family environment factors play a role in adolescents' involvement in organized activities?
Authors: Badura Petr , Madarasova Geckova Andrea , Sigmundova Dagmar , Sigmund Erik , van Dijk Jitse P. , Reijneveld Sijmen A. 
Published: June 2017

ABSTRACTThe study assessed the association of family environment factors with adolescents' participation in organized leisure‐time activities (OLTA). We used data on 10,472 Czech adolescents aged 11–15 years (49.2% boys) from the 2013/2014 Health Behaviour in School‐aged Children study. The associations of family support, the presence of parental screen‐time rules and joint family activities with participation in at least one OLTA were assessed using logistic regression. High family support and the presence of parental screen‐time rules were associated with higher odds of OLTA participation. Moreover, adolescents playing sports, indoor games and going for walks with their families at least weekly were more likely to participate in OLTA. Conversely, those spending time in joint family TV/video watching on most days were less likely to do so. A supportive family environment and direct parental involvement in their adolescent children's leisure are associated with OLTA participation in early to middle adolescence.
Construcción del perfil profesional del médico familiar en México
Authors: Gómez Clavelina Francisco Javier F. , Leyva Gonzalez Félix Arturo 
Published: June 2017

Introducción: El perfil profesional es un término que se usa con un significado poco preciso. Se emplea en el discurso académico y constituye un componente ineludible y sustantivo de planes de estudio y de aspectos vinculados con el ambiente laboral. En México, no se cuenta con un perfil profesional del médico familiar sustentado por elementos teóricos-metodológicos y de la práctica profesional para su construcción.
Objetivo: Construir el perfil profesional del médico familiar mexicano, a través de la aplicación de una estrategia de producción y validación basada en el grado de consenso entre académicos, formadores y representantes gremiales.
Método: Estudio censal, descriptivo, cuanticualitativo, prospectivo. Con base en las propuestas metodológicas de cuatro autores y en los recursos disponibles de participación (académicos, formadores y representantes gremiales), se seleccionó el modo I de IV para la validación del perfil. Se diseñó y aplicó un cuestionario electrónico de autorrespuesta para obtener la opinión de 71 participantes, acerca de las seis dimensiones o dominios consensuados que conforman el perfil profesional del especialista en medicina familiar. Se aplicó el cuestionario mediante una plataforma electrónica con acceso mediante correo electrónico. Se utilizó estadística descriptiva y análisis de contenido para categorizar las respuestas de cada reactivo.
Resultados: Se obtuvieron 34 respuestas completas (47.9%). El resumen cuantitativo de los términos encontrados permitió identificar las 10 palabras o frases más frecuentes para cada pregunta. El análisis cualitativo permitió identificar cuatro áreas de desempeño profesional y los rasgos o características profesionales del médico especialista en medicina familiar, los cuales se organizaron y redactaron para construir el perfil del médico familiar en México.
Conclusiones: El perfil profesional del médico especialista en medicina familiar mexicano obtenido en este estudio, permite establecer congruencia entre sus características y rasgos profesionales, sus competencias generales y específicas y las actividades que debe desarrollar en los diferentes contextos laborales en los que se desempeña.
Social media text normalization for Turkish
Authors: ERYİǦİT GÜLŞEN , TORUNOǦLU-SELAMET DİLARA 
Published: June 2017

AbstractText normalization is an indispensable stage in processing noncanonical language from natural sources, such as speech, social media or short text messages. Research in this field is very recent and mostly on English. As is known from different areas of natural language processing, morphologically rich languages (MRLs) pose many different challenges when compared to English. Turkish is a strong representative of MRLs and has particular normalization problems that may not be easily solved by a single-stage pure statistical model. This article introduces the first work on the social media text normalization of an MRL and presents the first complete social media text normalization system for Turkish. The article conducts an in-depth analysis of the error types encountered in Web 2.0 Turkish texts, categorizes them into seven groups and provides solutions for each of them by dividing the candidate generation task into separate modules working in a cascaded architecture. For the first time in the literature, two manually normalized Web 2.0 datasets are introduced for Turkish normalization studies. The exact match scores of the overall system on the provided datasets are 70.40 per cent and 67.37 per cent (77.07 per cent with a case insensitive evaluation).
CD123 target validation and preclinical evaluation of ADCC activity of anti-CD123 antibody CSL362 in combination with NKs from AML patients in remission
Authors: Xie L H , Biondo M , Busfield S J , Arruda A , Yang X , Vairo G , Minden M D 
Published: June 2017

AbstractDespite the heterogeneity of acute myeloid leukemia (AML), overexpression of the interleukin-3 receptor-α (CD123) on both the more differentiated leukemic blast and leukemic stem cells (LSCs) provides a therapeutic target for antibody treatment. Here we present data on the potential clinical activity of the monoclonal antibody CSL362, which binds to CD123 with high affinity. We first validated the expression of CD123 by 100% (52/52) of patient samples and the correlation of NPM1 and FLT3-ITD mutations with the high frequency of CD123 in AML. In vitro studies demonstrated that CSL362 potently induced antibody-dependent cell cytotoxicity (ADCC) of AML blasts including CD34+CD38−CD123+ LSCs by natural killer cells (NKs). Importantly, compared with healthy donor (HD) NKs, NKs drawn from AML patients in remission had a comparable ADCC activity against leukemic cells; of note, during remission, immature NKs were five times higher in AML patients than that in HDs. Significantly, we report a case where leukemic cells were resistant to autologous ADCC; however, the blasts were effectively lysed by CSL362 together with donor-derived NKs after allogeneic hematopoietic stem cell transplantation. These studies highlight CSL362 as a promising therapeutic option following chemotherapy and transplant so as to improve the outcome of AML patients.
Near-infrared absorption of π-stacking columns composed of trioxotriangulene neutral radicals
Authors: Ikabata Yasuhiro , Wang Qi , Yoshikawa Takeshi , Ueda Akira , Murata Tsuyoshi , Kariyazono Kazuki , Moriguchi Miki , Okamoto Hiroshi , Morita Yasushi , Nakai Hiromi 
Published: June 2017

AbstractA long-wavelength photoabsorption of organic molecules has been noticed because of the potential as materials. In addition to the extension of π conjugation, molecular aggregation has been utilized to realize the elongation of absorption wavelength. We report strong near-infrared absorptions of trioxotriangulene neutral radicals in the crystalline state and large-scale theoretical calculations of the radical assemblies interpreting the mechanism of optical properties. Polarized absorption spectra and X-ray diffraction of the crystals clarified that an unusual π-stacking column consisting of π-dimers is key for this absorption. Quantum chemical calculations based on time-dependent density functional theory revealed that the π-dimer shows an electronic transition between frontier orbitals generated by strong coupling of the delocalized singly occupied orbitals of monomers. The interdimer interaction of transition dipole moments, which are parallel to the column, elucidated the increase of absorption wavelength. The divide-and-conquer Green function method enabled the large-scale time-dependent density functional theory calculation up to a 60mer, where the maximum number of atoms is 4380, reproducing the near-infrared absorptions of trioxotriangulene crystals. The present method to investigate the mechanism of the long-wavelength photoabsorption is useful for developing organic materials consisting of stable neutral radicals.
H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
Authors: Wong Sook-San , DeBeauchamp Jennifer , Zanin Mark , Sun Yilun , Tang Li , Webby Richard 
Published: June 2017

AbstractConventional inactivated avian influenza vaccines have performed poorly in past vaccine trials, leading to the hypothesis that they are less immunogenic than seasonal influenza vaccines. We tested this hypothesis by comparing the immunogenicity of the H5N1 and H7N9 vaccines (avian influenza vaccines) to a seasonal trivalent inactivated influenza vaccine in naïve ferrets, administered with or without the adjuvants MF59 or AS03. Vaccine immunogenicity was assessed by measuring neutralizing antibody titers against hemagglutinin and neuraminidase and by hemagglutinin -specific IgG levels. Two doses of unadjuvanted vaccines induced low or no HA-specific IgG responses and hemagglutination-inhibiting titers. Adjuvanted vaccines induced comparable IgG-titers, but poorer neutralizing antibody titers for the H5 vaccine. All adjuvanted vaccines elicited detectable anti- neuraminidase -antibodies with the exception of the H5N1 vaccine, likely due to the low amounts of neuraminidase in the vaccine. Overall, the H5N1 vaccine had poorer capacity to induce neutralizing antibodies, but not HA-specific IgG, compared to H7N9 or trivalent inactivated influenza vaccine.