bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling Reference Production as the Probabilistic Combination of Multiple Perspectives
Authors: Mozuraitis Mindaugas , Stevenson Suzanne , Heller Daphna 
Published: February 2018

AbstractWhile speakers have been shown to adapt to the knowledge state of their addressee in choosing referring expressions, they often also show some egocentric tendencies. The current paper aims to provide an explanation for this “mixed” behavior by presenting a model that derives such patterns from the probabilistic combination of both the speaker's and the addressee's perspectives. To test our model, we conducted a language production experiment, in which participants had to refer to objects in a context that also included a visually misleading object (e.g., a crayon shaped like a Lego brick) whose function was either known to both partners, or known just to the speaker but not the addressee. Modeling results indicate that the experimental findings cannot be explained by assuming that speakers tailor a referring expression solely to their own perspective or to the perspective of their addressee. Instead, accounting for the behavioral pattern requires an approach where both perspectives influence the choice of referring expressions. Nevertheless, in our situation, speakers consider their partner's perspective more than their own.
Aortic bypass surgery for asymptomatic patients awaiting a kidney transplant: A word of caution
Authors: Franquet Quentin , Terrier Nicolas , Pirvu Augustin , Rambeaud Jean‐Jacques , Long Jean‐Alexandre , Janbon Benedicte , Tetaz Rachel , Malvezzi Paolo , Jouve Thomas , Descotes Jean‐Luc , Fiard Gaelle 
Published: February 2018

AbstractIntroductionIn the presence of severe aorto‐iliac calcification, aortic bypass surgery can be mandatory to allow kidney transplantation. The aim of our study was to evaluate the safety and outcomes of this strategy among asymptomatic patients.Materials and methodsWe retrospectively reviewed the files of all patients that had undergone vascular bypass surgery prior to kidney transplantation between November 2004 and March 2016. All patients undergoing aortic bypass surgery prior to kidney transplantation without any vascular‐related symptoms were included.ResultsTwenty‐one asymptomatic patients were included. Ten patients (48%) have not received a kidney transplant. Four patients died before kidney transplantation, including 2 deaths related to the bypass surgery (9.5%). Early post‐operative morbidity involved 11 cases. Eleven patients (52%) were transplanted. Transplanted patients were significantly younger (median age 60 [56‐61] vs 67 [60‐72] years, P = .04) at the time of bypass and were less frequently treated for coronary heart disease (9% vs 50%, P = .06).ConclusionAortic bypass surgery performed prior to kidney transplantation among asymptomatic patients has significant mortality and morbidity rates. When transplantation is possible, the results are satisfying. Larger studies are required to define the selection criteria, such as age and coronary heart disease.
Effect of the eucalypt lerp psyllid Glycaspis brimblecombei on adult feeding, oviposition‐site selection, and offspring performance of the bronze bug, Thaumastocoris peregrinus
Authors: Martínez Gonzalo , González Andrés , Dicke Marcel 
Published: February 2018

AbstractOviposition‐site selection may be greatly affected by competitive plant‐mediated interactions between phytophagous insects but these interactions have been poorly investigated on trees. Here, we evaluated the potential interaction between two invasive pests of Eucalyptus trees, the red gum lerp psyllid, Glycaspis brimblecombeiMoore (Hemiptera, Sternorrhyncha: Aphalaridae), and the bronze bug, Thaumastocoris peregrinusCarpintero et Dellapé (Heteroptera: Thaumastocoridae). We assessed the effect of the co‐occurrence of G. brimblecombei on the selection of feeding and oviposition sites by T. peregrinus females using dual‐choice bioassays. We compared developmental time and survival of the first instar of nymphs reared on healthy Eucalyptus tereticornisSmith (Myrtaceae) leaves and on leaves infested with the lerp psyllid, either with or without lerps (i.e., white conical sweet‐tasting structures, secreted during the nymphal stage). Bronze bug females prefer to oviposit on lerp‐carrying leaves but we found no difference in feeding preference when compared to healthy leaves. Infestation with the lerp psyllid hampered nymphal performance in terms of developmental time and survival, although the presence of lerps reverted the effect in survival and shortened the duration of the initial instar. These results display an interaction between these two insect species that affects both the oviposition preference of T. peregrinus females and the nymphal performance. Although there seems to be a discrepancy between mother preference and offspring performance, feeding on the lerps may prove beneficial to the offspring under long‐term conditions and multiple infestation by other pests and diseases.
Efficacy, safety, and cost of pomalidomide in relapsed and refractory multiple myeloma
Authors: Gueneau Pauline , Chretien Marie‐Lorraine , Cransac‐Miet Amelie , Aho Ludwig Serge , Lafon Ingrid , Favennec Camille , Guy Julien , Caillot Denis , Boulin Mathieu 
Published: February 2018

AbstractObjectivesTo investigate the efficacy, safety, and cost of a pomalidomide‐dexamethasone regimen in patients with relapsed and refractory multiple myeloma (RRMM).MethodsAll patients (n = 63) treated with pomalidomide‐dexamethasone for RRMM in our university hospital between August 2013 and October 2015 were included.ResultsPomalidomide was discontinued early due to progression (before the 4th cycle) in 17 (27%) patients. No case was discontinued for intolerance. The only independent factor that predicted early pomalidomide discontinuation was time from diagnosis to pomalidomide initiation <3 years. Overall response rate was 51% including complete response in 8%, very good partial response in 25%, and partial response in 19% patients. Thirteen (33%) patients showed stable disease. Median overall survival was 6.4 months in the 17 patients who discontinued pomalidomide early vs 26.8 months in the 14 patients with stable disease vs not achieved in the 32 responders (log‐rank; P < 10−3). The most common grade ≥3 adverse events were neutropenia (14%) and infections (25%). The incremental cost‐effectiveness ratio of pomalidomide‐dexamethasone compared with dexamethasone alone was estimated at €39 911 per life‐year gained.ConclusionsThe study demonstrated that pomalidomide‐dexamethasone regimen has a long‐term favorable safety‐efficacy profile in RRMM patients. The survival benefit is substantial even in patients with stable disease.
Frontal lobe epileptic seizures are accompanied by elevated pitch during verbal communication
Authors: Speck Iva , Echternach Matthias , Sammler Daniela , Schulze‐Bonhage Andreas 
Published: February 2018

SummaryThe objective of our study was to assess alterations in speech as a possible localizing sign in frontal lobe epilepsy. Ictal speech was analyzed in 18 patients with frontal lobe epilepsy (FLE) during seizures and in the interictal period. Matched identical words were analyzed regarding alterations in fundamental frequency (ƒo) as an approximation of pitch. In patients with FLE, ƒo of ictal utterances was significantly higher than ƒo in interictal recordings (p = 0.016). Ictal ƒo increases occurred in both FLE of right and left seizure origin. In contrast, a matched temporal lobe epilepsy (TLE) group showed less pronounced increases in ƒo, and only in patients with right‐sided seizure foci. This study for the first time shows significant voice alterations in ictal speech in a cohort of patients with FLE. This may contribute to the localization of the epileptic focus. Increases in ƒo were interestingly found in frontal lobe seizures with origin in either hemisphere, suggesting a bilateral involvement to the planning of speech production, in contrast to a more right‐sided lateralization of pitch perception in prosodic processing.
An efficient method for eccrine gland isolation from human scalp
Authors: Jimenez Francisco , Alam Majid , Hernandez Irene , Poblet Enrique , Hardman Jonathan A. , Paus Ralf 
Published: February 2018

AbstractWe describe a simple and efficient method to isolate eccrine sweat glands from the human scalp. This method is inspired by the hair graft harvesting method used in hair transplantation. Based on the recently described anatomical relationship between the scalp hair follicle and the eccrine gland, we have found that scalp follicular unit grafts are an excellent eccrine gland isolation source, especially for the coiled component. In order to make the gland visible for stereoscopic microdissection, the follicular units need to be previously stained with a vital dye like methylene blue or neutral red. The simplicity and efficiency of this isolation method should encourage further research into human eccrine sweat gland function which has always been hindered by the difficulty of gland isolation.
Experimental characterisation of a CuAg alloy for thermo‐mechanical applications. Part 2: Design strain‐life curves estimated via statistical analysis
Authors: Benasciutti D. , Srnec Novak J. , Moro L. , De Bona F. 
Published: February 2018

AbstractStrain‐life fatigue data on copper alloys, especially type CuAg, are seldom available in the literature. This work fills this gap by estimating the strain‐life curves of a CuAg alloy used for thermo‐mechanical applications, from isothermal low‐cycle fatigue tests at 3 temperatures (room temperature, 250°C, 300°C). Regression analysis is used to estimate the median fatigue curves at 50% survival probability. The comparison of median curves with the Universal Slopes Equation model, calibrated on monotonic tensile properties, shows a fairly good agreement. Design strain‐life curves with a lower failure probability and given confidence are estimated by several approximate statistical methods (“Equivalent Prediction Interval,” univariate tolerance interval, Owen's tolerance interval for regression). When higher survival probabilities are considered, the results show a marked decrease in the allowable design strain at a prescribed fatigue life. The suggested procedure thus improves the durability analysis of components loaded thermo‐mechanically.
Oral health of the Latin American elders: What we know and what we should do—Position paper of the Latin American Oral Geriatric Group of the International Association for Dental Research
Authors: León Soraya , De Marchi Renato J. , Tôrres Luisa H. , Hugo Fernando N. , Espinoza Iris , Giacaman Rodrigo A. 
Published: February 2018

ObjectiveThe purpose of this review was to gather information and discuss oral health status of older people in the Latin American and Caribbean region (LAC).BackgroundScarce data are available to portrait the oral situation of older people in the region.Material and methodsThis review paper is the result of a meeting of the IADR's Latin American Geriatric Oral Research Group held in Porto Alegre, Brazil, in November of 2016, part of the activities of an IADR Regional Development Programme (RDP). A group of researchers from 8 countries of LAC held a discussion using 5 questions related to the oral health situation of older Latin Americans, the most appropriate strategies to face the problem and the challenges for the future, with an open discussion format. In a second step, a group of 6 experts refined the answers and reviewed the existent literature.ResultsThe review of the evidence revealed that only a few LAC countries have information, which suggests the need for multinational efforts to understand the oral health status and programmes in place. Of the few studies available, it is possible to observe poor oral health as a common feature of older adults in the region.ConclusionThere is a need for the development of national surveys and standardised tools for the assessment of oral health in older adults. Also, intense advocacy to modify and influence public health policies in the different countries of the LAC is strongly recommended.
Japanese version of the Montreal Cognitive Assessment cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults
Authors: Nara Marina , Sugie Masamitsu , Takahashi Tetsuya , Koyama Teruyuki , Sengoku Renpei , Fujiwara Yoshinori , Obuchi Shuichi , Harada Kazumasa , Kyo Shunei , Ito Hideki 
Published: February 2018

AimPhysical exercise improves cognitive function in people with mild cognitive impairment (MCI). However, information about whether the degree of MCI before exercise training affects improvement in cognitive function is lacking. Therefore, we aimed to investigate the cut‐off value in a MCI screening tool that predicts reversal to normal cognitive function after exercise training in older adults with MCI.MethodsParticipants included 112 Japanese community‐dwelling older adult outpatients (37 men, 75 women; mean age 76.3 years). We administered the Japanese version of the Montreal Cognitive Assessment (MoCA‐J) before and after exercise training. MCI was defined as a MoCA‐J score <26. All participants underwent exercise training 2 days per week for 6 months, according to American Heart Association guidelines.ResultsThe prevalence of MCI was 65.2%. After exercise training, 46.6% of participants with MCI reversed to normal cognitive function. The MoCA‐J cut‐off score to predict cognitive function potentially reversible to normal was 23, with receiver operating characteristic analysis showing an area under the curve of 0.80, sensitivity of 79.4% and specificity of 69.2%. Multiple logistic regression analysis to predict non‐MCI after exercise training showed that MoCA‐J score ≥23 (OR 6.9, P < .001), female sex (OR 3.4, P = .04) and age (OR 0.9, P = .04) were independent determinants.ConclusionsThe MoCA‐J cut‐off score of 23 might be useful to predict cognitive function that is potentially reversible to normal among community‐dwelling Japanese older adults with MCI. Geriatr Gerontol Int 2018; 18: 833–838
High plasma adiponectin levels are associated with frailty in a general old‐old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study
Authors: Nagasawa Motonori , Takami Yoichi , Akasaka Hiroshi , Kabayama Mai , Maeda Satomi , Yokoyama Serina , Fujimoto Taku , Nozato Yoichi , Imaizumi Yuki , Takeda Masao , Itoh Norihisa , Takeya Yasushi , Yamamoto Koichi , Sugimoto Ken , Nakagawa Takeshi , Masui Yukie , Arai Yasumichi , Ishizaki Tatsuro , Ikebe Kazunori , Gondo Yasuyuki , Kamide Kei , Rakugi Hiromi 
Published: February 2018

AimThe objective of the present study was to investigate the association between frailty and plasma adiponectin levels in a general population of Japanese older adults.MethodsThe volunteer older adults, aged approximately 83 years, were recruited randomly from a general population in the Japanese Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. We used the modified Cardiovascular Health Study criteria to assess the frailty status of the study participants. The study participants were classified as non‐frail, pre‐frail and frail according to their physical activities. We compared plasma adiponectin levels among these three groups and applied a multivariate logistic regression analysis including plasma adiponectin levels to clarify the factors associated with frailty status in the cross‐sectional design.ResultsThe mean age of the participants was 83.1 ± 0.9 years, and 51.8% were men. The frailty index was available to assess 353 participants, of whom 24.6% were classified as non‐frail, 62.3% as prefrail and 13.0% as frail. The log‐transformed plasma adiponectin levels increased stepwise in the following order: non‐frail, pre‐frail and frail. A multivariate logistic regression analysis showed that higher plasma adiponectin levels, a higher estimated glomerular filtration rate and lower hemoglobin levels were independent determinants for pre‐frail/frail status compared with non‐frail status.ConclusionsThe present study showed that higher plasma adiponectin levels were associated with frailty status in older Japanese adults in the general population. Further longitudinal study is essential to clarify the role of plasma adiponectin in the progression of frailty. Geriatr Gerontol Int 2018; 18: 839–846
Living alone is associated with an increased risk of institutionalization in older men: A follow‐up study in Hamanaka Town of Hokkaido, Japan
Authors: Takeuchi Miki , Showa Satoko , Kitazawa Kazutoshi , Mori Mitsuru 
Published: February 2018

AimIn order to clarify the risks of institutionalization or mortality among older adults living alone compared with those not living alone, we carried out a prospective study on older adults in Hamanaka Town in the far eastern part of Hokkaido, Japan.MethodsAll 978 community‐dwelling residents aged 70–85 years in the town were chosen as study candidates between February and May of 2014. Written informed consent was obtained from 562 residents (57.5%), and a self‐administered questionnaire, including a question about living arrangements, was mailed to them. They returned the completed questionnaire to us in 2014. A follow‐up survey was carried out with a questionnaire mailed to each participant about institutionalization and mortality, three times, in February of 2015 and 2016, and in April of 2017. Hazard ratios and 95% confidence intervals were calculated with the Cox proportional hazards model.ResultsLiving alone was significantly associated with an increased risk of institutionalization in the male participants, after adjusting for age, sex and having daily support from family around a participant (hazard ratio 5.71, 95% confidence interval 1.17–27.83), although it was not significant in the total participants or the female participants. Additional adjustments for a history of having common diseases did not change the results meaningfully. Living alone was not associated with the risk of mortality in the total participants, the male participants or the female participants.ConclusionsPoor social support in social networks for older men living alone may be etiologically associated with increased risk of institutionalization in rural area. Further study with a larger sample size is necessary to confirm this finding. Geriatr Gerontol Int 2018; 18: 867–872
Population‐based study examining the utilization of preventive medicines by older people in the last year of life
Authors: Narayan Sujita W , Nishtala Prasad S 
Published: February 2018

AimTo examine the patterns of preventive medicines (PM) use in the last year of life of older adults.MethodsThis study cohort included individuals (n = 99 809) aged ≥75 years who were in their last year of life. PM examined in this study included low‐dose aspirin (≤325 mg/day), clopidogrel, dipyridamole, warfarin, dabigatran, statins and bisphosphonates. Logistic regression models examined the influence of age, sex, multimorbidity, socioeconomic status, and a diagnosis of cancer on the number and type of PM prescribed from 2007 to 2012.ResultsThe number of PM prescribed was higher for men compared with women (OR 1.11, 95% CI 1.08–1.14). Increasing age did not have an effect on the number of PM prescribed. The use of clopidogrel increased almost threefold from 2007 to 2012 (OR 5.53, 95% CI 4.61–6.65). In contrast, bisphosphonates use decreased significantly during the same period (OR 0.35, 95% CI 0.32–0.39). Individuals with a diagnosis of cancer had increased odds of PM utilization for antiplatelets, aspirin monotherapy and statins, which had remarkably high odds (OR 4.11, 95% CI 3.88–4.34, P < 0.001).ConclusionsThe present explorative study highlighted that some PM, such as statins, continue to be prescribed until death, particularly those that might have been beneficial earlier in life, but have an uncertain or unfavorable risk–benefit ratio towards the end‐of‐life. Geriatr Gerontol Int 2018; 18: 892–898
Automated Extraction of a Five‐Year LA‐ICP‐MS Trace Element Data Set of Ten Common Glass and Carbonate Reference Materials: Long‐Term Data Quality, Optimisation and Laser Cell Homogeneity
Authors: Evans David , Müller Wolfgang 
Published: February 2018

LA‐ICP‐MS is increasingly applied to obtain quantitative multi‐element data with minimal sample preparation, usually achieved by calibration using reference materials (RMs). However, some ubiquitous RMs, for example the NIST SRM 61× series glasses, suffer from reported value uncertainties for certain elements. Moreover, no long‐term data set of analyses conducted over a range of ablation and tuning conditions exists. Thus, there has been little rigorous examination of the extent to which offsets between measured and reported values are the result of error in these values rather than analytically induced fractionation. We present new software (‘LA‐MINE’), capable of extracting LA‐ICP‐MS data with no user input, and apply this to our system, yielding over 5 years of data (~ 5700 analyses of ten glass and carbonate RMs). We examine the relative importance of systematic analytical bias and possible error in reported values through a mass‐specific breakdown of fourteen of the most commonly determined elements. Furthermore, these data, obtained under a wide range of different ablation conditions, enable specific recommendations of how data quality may be improved, for example the role of diatomic gas, the effect of differential inter‐glass fractionation factors and choice of transport tubing material. Finally, these data demonstrate that the two‐volume Laurin ablation cell is characterised by no discernible spatial heterogeneity in measured trace element ratios.
Empirical Equations to Predict the Characteristics of Hyporheic Exchange in a Pool‐Riffle Sequence
Authors: Huang Peng , Chui Ting Fong May 
Published: February 2018

AbstractThe hyporheic zone is the saturated interstitial space surrounding a stream. Water actively moves into, through, and out of the hyporheic zone, resulting in hyporheic exchange (HE), which is crucial to the physicochemical and biological processes in these systems. The HE in pool‐riffle sequences is one of the most common forms of HE and has received a vast amount of attention. This study aimed to derive empirical equations to predict the scale, median residence time (RT), and flux of HE in a single pool‐riffle sequence by considering stream discharge, bedform geometry, streambed hydraulic conductivity, and groundwater flow. The resulting equations, which were derived using previously published data, allow quick approximations of the mean depth, median RT, and flux of HE in a single pool‐riffle sequence. Therefore, these equations can be used to conveniently and efficiently generate insights into the physicochemical and biological processes, facilitating the prediction of water quality and the restoration of HE in stream rehabilitation. The overall framework of the derived equations is also generally applicable to considering HE with additional influential factors (e.g., stream width, sinuosity, bed slope, alluvial depth) and cases with more available data.