bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Multi-inclined Holes on the Creep Properties of Nickel-Based Superalloy
Authors: Li Dongfan , Wen Zhixun , Wang Shaofei , Liu Chenyu , Yue Zhufeng 
Published: June 2016

AbstractThe creep properties of GH3536 nickel-based superalloy plate specimens without/with multi-inclined holes were studied under applied stress 80/90/100 MPa at 850 ℃, respectively. Interesting finding is focused on the inflection point, that is, both the fraction elongation and creep strain achieve the maximum value under 90 MPa. Further study is carried out by two methods: the finite element analysis (FEA) calculation and scanning electron microscope (SEM). The FEA results show that the dangerous areas appear in the regions near the end of ellipse axis along the inclined angle orientation, which is similar to the actual fracture appearances. What is more, the tiny holes and dimples are the main characters of creep fracture for multi-inclined hole specimens, whereas the creep fracture of specimens without holes is the result of growth and coalescence of voids. In addition, based on creep performance, laser drilling is better than that of the electric spark drilling, which provides a proof that the creep performance of specimens with multi-inclined holes will be better with the improvement of the drilling process.
Effects of Laser Shock Processing on Fatigue Performance of Ti-17 Titanium Alloy
Authors: Huang Shuai , Zhu Ying , Guo Wei , Qiao Hongchao , Diao Xungang 
Published: June 2016

Abstract
Ti-17 titanium alloy was treated by laser shock processing (LSP) and the high-frequency fatigue properties were evaluated. The fatigue fracture and the microstructures were observed by scanning electron microscope (SEM) and transmission electron microscope (TEM). The result shows that the average fatigue life of the LSP sample increases 2.62 times at maximum stress 300 MPa under stress ratio is 0.1. The micro-hardness of the samples subjected to LSP increases 20 % compared with the basic material. The proliferation and tangles of dislocations of Ti-17 occurs and the density of dislocation increases after LSP treatment. The high dislocation density of LSP impacts changes the initiation of crack from corner to subsurface, and hinders the crack extension, thus increases the fatigue performance of the Ti-17.
Word learning in Italian preschool children with cochlear implants
Authors: Majorano Marinella , Guerzoni Letizia , Murri Alessandra , Guidotti Laura , Morelli Marika , Cuda Domenico 
Published: June 2016

AbstractThe aim of this study was to assess word learning in Italian preschool children with cochlear implants (CIs). Fifteen children with CIs (CI-group) and two groups of typically developing (TD) children, one age-matched group (CATD-group) and one of the same hearing age (HATD-group), participated in the study. A word-learning task was assigned to each child in which the numbers of correct, incorrect and absent responses were considered, both for comprehension and production. The learning procedure comprised eight nonwords and the children were tested immediately (fast mapping) and after 2 h (retention). In the word-learning task, the children with CIs displayed lower scores than the CATD-group and higher scores than the HATD-group both for comprehension and production and for fast mapping and retention. Fast mapping (comprehension and production) is significantly related to the children’s age at CI activation, while in the retention phase the correlation is significant only for comprehension. Although children with CI display slight limitations in word learning relative to age-matched children, the limitation is less severe with earlier CI activation.
Crystal structure of (E)-1-(4-(((E)-3,5-dibromo-2-hydroxybenzylidene)amino)phenyl)ethan-1-one O-methyl oxime, C17H16Br2N2O2
Authors: Zhao Li , Zhao Ji-Xing , An Qin-Qin , Wang Fei 
Published: June 2016

Abstract
C17H16Br2N2O2, monoclinic, P21/c (no. 14), a = 9.2648(14) Å, b = 13.3034(16) Å, c = 14.510(2) Å, β = 105.261(15)°, V = 1725.4(4) Å3, Z = 4, R
gt
(F) = 0.0679, wR
ref
(F
2) = 0.1657, T = 293(2) K.
Synthesis and characterization of pure and nanosized hydroxyapatite bioceramics
Authors: Anwar Aneela , Kanwal Qudsia , Akbar Samina , Munawar Aisha , Durrani Arjumand , Hassan Farooq Masood 
Published: June 2016

AbstractSynthetic nanosized hydroxyapatite (HA) particles (<120 nm) were prepared using a co-precipitation technique by adopting two different routes – one from an aqueous solution of calcium nitrate tetrahydrate and diammonium hydrogen phosphate at pH 10 and the other by using calcium hydroxide and phosphoric acid as precursors at pH 8.5 and reaction temperature of 50°C. The lattice parameters of HA nanopowder were analogous to reference [Joint Committee on Powdered Diffraction Standards (JCPDS)] pattern no. 09-432. No decomposition of HA into other phases was observed even after heating at 1000°C in air for 1 h. This observation revealed the high-temperature stability of the HA nanopowder obtained using co-precipitation route. The effects of preliminary Ca/P molar ratio, precipitation, pH and temperature on the evolution of phase and crystallinity of the nanopowder were systematically examined and optimized. The product was evaluated by techniques such as X-ray-diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and Raman spectroscopy analyses. The chemical structural analysis of the as-prepared HA sample was performed using X-ray photoelectron spectroscopy (XPS). After heat treatment at 1000°C for 1 h and ageing for 15 h, the product was obtained as a phase-pure, highly crystalline HA nanorods.
IUPAC/CITAC Guide: Classification, modeling and quantification of human errors in a chemical analytical laboratory (IUPAC Technical Report)
Authors: Kuselman Ilya , Pennecchi Francesca 
Published: June 2016

Abstract
The classification, modeling, and quantification of human errors in routine chemical analysis are described. Classifications include commission errors (mistakes and violations) and omission errors (lapses and slips) in different scenarios at different steps of the chemical analysis. A Swiss cheese model is used to characterize error interaction with a laboratory quality system. The quantification of human errors in chemical analysis, based on expert judgments, i.e. on the expert(s) knowledge and experience, is applied. A Monte Carlo simulation of the expert judgments was used to determine the distributions of the error quantification scores (scores of likelihood and severity, and scores of effectiveness of a laboratory quality system against the errors). Residual risk of human error after the error reduction by the laboratory quality system and consequences of this risk for quality and measurement uncertainty of chemical analytical results are discussed. Examples are provided using expert judgments on human errors in pH measurement of groundwater, multi-residue analysis of pesticides in fruits and vegetables, and elemental analysis of geological samples by inductively coupled plasma mass spectrometry.
IonLab – a remote-controlled experiment for academic and vocational education and training on extraction chromatography and ion exchange
Authors: Schulz Wolfgang , Fournier Claudia , Vahlbruch Jan-Willem , Walther Clemens 
Published: June 2016

Abstract
As a major contribution to modern web-based education and training in nuclear chemistry we have built and operated a remote-controlled experiment – IonLab – as part of the integrated EUFP7 project CINCHII. The setup is suitable for teaching basics on extraction chromatography and ion exchange using radionuclides. We describe separation of the beta emitting nuclides Sr-90 and Y-90 followed by radiometric detection, but the experiment is easily adapted to other separation schemes. This approach is aimed at institutions in academic or vocational education who need to convey the skills of handling radioactive (or otherwise dangerous, e.g. biotoxic) substances without appropriately licensed laboratory space for teaching. This camera-monitored remote controlled lab experiment has proved to be much closer to a real hands-on training and superior to a mere computer simulation.
Entropy Production Within a Pulsed Bose–Einstein Condensate
Authors: Heinisch Christoph , Holthaus Martin 
Published: June 2016

Abstract
We suggest to subject anharmonically trapped Bose–Einstein condensates to sinusoidal forcing with a smooth, slowly changing envelope, and to measure the coherence of the system after such pulses. In a series of measurements with successively increased maximum forcing strength, one then expects an adiabatic return of the condensate to its initial state as long as the pulses remain sufficiently weak. In contrast, once the maximum driving amplitude exceeds a certain critical value there should be a drastic loss of coherence, reflecting significant heating induced by the pulse. This predicted experimental signature is traced to the loss of an effective adiabatic invariant, and to the ensuing breakdown of adiabatic motion of the system’s Floquet state when the many-body dynamics become chaotic. Our scenario is illustrated with the help of a two-site model of a forced bosonic Josephson junction, but should also hold for other, experimentally accessible configurations.
Impaired growth and intracranial calcifications in autosomal dominant hypocalcemia caused by a GNA11 mutation
Authors: Tenhola Sirpa , Voutilainen Raimo , Reyes Monica , Toiviainen-Salo Sanna , Jüppner Harald , Mäkitie Outi 
Published: June 2016

Objective
Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia and inappropriately low PTH concentrations. ADH type 1 is caused by activating mutations in the calcium-sensing receptor (CASR), a G-protein-coupled receptor signaling through α11 (Gα11) and αq (Gαq) subunits. Heterozygous activating mutations in GNA11, the gene encoding Gα11, underlie ADH type 2. This study describes disease characteristics in a family with ADH caused by a gain-of-function mutation in GNA11.

Design
A three-generation family with seven members (3 adults, 4 children) presenting with ADH.

Methods
Biochemical parameters of calcium metabolism, clinical, genetic and brain imaging findings were analyzed.

Results
Sanger sequencing revealed a heterozygous GNA11 missense mutation (c.1018G>A, p.V340M) in all seven hypocalcemic subjects, but not in the healthy family members (n=4). The adult patients showed clinical symptoms of hypocalcemia, while the children were asymptomatic. Plasma ionized calcium ranged from 0.95 to 1.14mmol/L, yet plasma PTH was inappropriately low for the degree of hypocalcemia. Serum 25OHD was normal. Despite hypocalcemia 1,25(OH)2D and urinary calcium excretion were inappropriately in the reference range. None of the patients had nephrocalcinosis. Two adults and one child (of the two MRI scanned children) had distinct intracranial calcifications. All affected subjects had short stature (height s.d. scores ranging from −3.4 to −2.3 vs −0.5 in the unaffected children).

Conclusions
The identified GNA11 mutation results in biochemical abnormalities typical for ADH. Additional features, including short stature and early intracranial calcifications, cosegregated with the mutation. These findings may indicate a wider role for Gα11 signaling besides calcium regulation.
Impacto de las TIC en la formación de docentes universitarios: retos de la mediación ecológica en la enseñanza y el aprendizaje
Authors: Mendoza Melo Esperanza , Cuervo Luz Marina , Buitrago William Fernando , González-Gutiérrez Luis Felipe 
Published: June 2016

<p class="p1"> En este artículo se describen los principales resultados encontrados en</p><p class="p1">el proyecto de investigación “Implicaciones de las TIC en los estilos de</p><p class="p1">enseñanza y aprendizaje en la formación de los especialistas en la modalidad</p><p class="p1">a distancia de la Fundación Universitaria Los Libertadores”. El</p><p class="p2">objetivo que orienta la investigación está dado en determinar la forma</p><p class="p2">como el uso y apropiación de las TIC potencian la mediación efectiva en</p><p class="p1"> los procesos de enseñanza aprendizaje en la formación de los especialistas</p><p class="p1">de la Fundación Universitaria Los Libertadores. A partir del diseño de</p><p class="p1">una metodología de investigación cualitativa se exploraron tres aspectos</p><p class="p1">fundamentales: i) la identificación y usos de las TIC en los procesos de enseñanza</p><p class="p1">y aprendizaje de los docentes, ii) las relaciones establecidas entre</p><p class="p1">esas TIC y los procesos de formación de la Fundación Universitaria Los</p><p class="p1">Libertadores, iii) sistematizar algunas experiencias significativas. Para tal</p><p class="p1">efecto, se realizaron entrevistas a profundidad y encuestas a 38 docentes</p><p class="p1">de las especializaciones en Informática y Multimedia en Educación y</p><p class="p1">Pedagogía de la Lúdica en las ciudades de Sahagún, Corinto, Popayán y</p><p class="p2">Santiago de Tolú. Los resultados indican que la mediación, compromiso</p><p class="p2">y conocimientos adquiridos se potencian en sus prácticas pedagógicas,</p><p class="p2">además de fortalecer las relaciones que construyen con sus estudiantes.</p>
Historia, memoria y palabra: propuesta y experiencia de un espacio académico en Educación Superior
Authors: Polanía González Javier , Rivera Venegas Juan Carlos 
Published: June 2016

<p class="p1"> </p><p class="p2">Este texto presenta la reflexión realizada por un grupo de profesores del Departamento de Formación Lasallista –unidad académica que propicia la formación integral de la comunidad universitaria a partir de la profundización, transmisión y generación de conocimientos que cuestionen, iluminen, dialoguen y aporten soluciones para las actuales problemáticas del mundo– en torno a una asignatura en pregrado, común a todos los programas, dirigida a repensar el mensaje religioso desde el enfoque de la historia, la memoria y la palabra. </p><p class="p8">El espacio pretende hacer un mayor énfasis en la búsqueda de sentido dando valor a la memoria, utilizando los avances que se han producido en torno a la discusión sobre esta en los diversos contextos de las ciencias sociales, teológicas y del escenario político, particularmente las masacres cometidas en el conflicto armado colombiano, para colocarlos en juego a propósito de construir una propuesta académica que desde la construcción del sentido propicie la elaboración de narrativas personales y sociales de vida y de creencia vinculadas a la constitución de sujetos humanistas, democráticos y abiertos al diálogo interreligioso e intercultural. La asignatura se desarrolla semestralmente desde el segundo semestre de 2011; se presentan logros, dificultades y retos de esta experiencia que ha contribuido a desarrollar procesos de sensibilización en los jóvenes de diferentes programas y facultades. </p>
Dificultades en la enseñanza de las operaciones con números racionales en la educación secundaria
Authors: Castaño Arbeláez Néstor Mario 
Published: June 2016

<p class="p1"> En esta investigación se determinan las dificultades que se le presentan</p><p class="p1">a los docentes de educación básica secundaria en el área de matemáti<span class="s1">cas,</span></p><p class="p2">más específicamente en la enseñanza de los números racionales y</p><p class="p1"> sus operaciones básicas. El estudio es de tipo mixto, pero con un enfoque</p><p class="p1">dominante o principal, con tendencia a lo cualitativo, además, es de corte</p><p class="p1">descriptivo. Se sustentó teóricamente en Polya (1945), Ausubel (1963),</p><p class="p1">Brousseau (1976), Kieren (1980), Duval (1993), Freudenthal (1994), Porlán</p><p class="p2">(1997), D’Amore (2004), Creswell (2005), Posada &amp; Villa (2007), Fandiño</p><p class="p2">(2009), et al. Se aplicó primero un cuestionario con diez preguntas cerradas </p><p class="p1"> cuyas respuestas se ubican en una escala Likert, las cuales fueron analizadas</p><p class="p1">con el paquete estadístico SPSS, cada una de estas preguntas tenía su</p><p class="p1">respectiva argumentación, las cuales se analizaron con el software cualita<span class="s1">tivo</span></p><p class="p2">Atlas.ti; luego se aplicó un taller con una pregunta abierta y cinco pro<span class="s2"> blemas,</span></p><p class="p1">los instrumentos se validaron con una prueba piloto, realizada en</p><p class="p2">una escuela normal, después de su validación se aplicaron en 24 colegios</p><p class="p1"> públicos y privados de la ciudad de Manizales, dirigidos a los docentes de</p><p class="p2">bachillerato del área de matemáticas de todos los grados, 70 docentes participaron en la encuesta y 12 en el taller. Los resultados evidenciaron que</p><p class="p1"> los docentes sí poseen ciertas dificultades en la enseñanza de los números</p><p class="p2">racionales con sus operaciones, puesto que como lo mencionan algunos</p><p class="p1"> de ellos, carecen de mejores métodos y estrategias de enseñanza.</p>
BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans
Authors: Hyun Moonjung , Kim Jeongho , Dumur Catherine , Schroeder Frank C , You Young-Jai 
Published: June 2016

Abstract
Environmental stress triggers multilevel adaptations in animal development that depend in part on epigenetic mechanisms. In response to harsh environmental conditions and pheromone signals, Caenorhabditis elegans larvae become the highly stress-resistant and long-lived dauer. Despite extensive studies of dauer formation pathways that integrate specific environmental cues and appear to depend on transcriptional reprogramming, the role of epigenetic regulation in dauer development has remained unclear. Here we report that BLMP-1, the BLIMP-1 ortholog, regulates dauer formation via epigenetic pathways; in the absence of TGF-β signaling (in daf-7 mutants), lack of blmp-1 caused lethality. Using this phenotype, we screened 283 epigenetic factors, and identified lin-40, a homolog of metastasis-associate protein 1 (MTA1) as an interactor of BLMP-1. The interaction between LIN-40 and BLMP-1 is conserved because mammalian homologs for both MTA1 and BLIMP-1 could also interact. From microarray studies, we identified several downstream target genes of blmp-1: npr-3, nhr-23, ptr-4, and sams-1. Among them S-adenosyl methionine synthase (SAMS-1), is the key enzyme for production of SAM used in histone methylation. Indeed, blmp-1 is necessary for controlling histone methylation level in daf-7 mutants, suggesting BLMP-1 regulates the expression of SAMS-1, which in turn may regulate histone methylation and dauer formation. Our results reveal a new interaction between BLMP-1/BLIMP-1 and LIN-40/MTA1, as well as potential epigenetic downstream pathways, whereby these proteins cooperate to regulate stress-specific developmental adaptations.
Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster
Authors: Lin Chun-Chieh , Potter Christopher J 
Published: June 2016

Abstract
Gene conversions occur when genomic double-strand DNA breaks (DSBs) trigger unidirectional transfer of genetic material from a homologous template sequence. Exogenous or mutated sequence can be introduced through this homology-directed repair (HDR). We leveraged gene conversion to develop a method for genomic editing of existing transgenic insertions in Drosophila melanogaster. The clustered regularly-interspaced palindromic repeats (CRISPR)/Cas9 system is used in the homology assisted CRISPR knock-in (HACK) method to induce DSBs in a GAL4 transgene, which is repaired by a single-genomic transgenic construct containing GAL4 homologous sequences flanking a T2A-QF2 cassette. With two crosses, this technique converts existing GAL4 lines, including enhancer traps, into functional QF2 expressing lines. We used HACK to convert the most commonly-used GAL4 lines (labeling tissues such as neurons, fat, glia, muscle, and hemocytes) to QF2 lines. We also identified regions of the genome that exhibited differential efficiencies of HDR. The HACK technique is robust and readily adaptable for targeting and replacement of other genomic sequences, and could be a useful approach to repurpose existing transgenes as new genetic reagents become available.
Politik Hukum Perlindungan Hakim
Authors: Faisal Akbar 
Published: June 2016

Abstract: The independence of the judicial power is a must and an absolute guarantee given to the judge. Judges should be independent of any pressures that may disturb his contemplation in making a decision that determines one's fate. The independence of the key is not only focused on how the pressure from outside in order to judge themselves neutral decision, but also expanded the independence of a judge rules that govern self itself. Judges can not be equated with the State Civil Apparatus employees, because the position is different judges. Placement of this is not specifically regulated in the country of Indonesia. It could be argued that these ideals are still owed by the constitution of this country when compared to other law enforcement officials who already have the legality of their own profession as prosecutors, police and lawyers.Abstrak: Independensi kekuasaan kehakiman merupakan garansi yang harus dan mutlak diberikan kepada Hakim. Hakim harus independen dari tekanan manapun yang dapat mengganggu kontemplasinya dalam membuat sebuah putusan yang menentukan nasib seseorang. Kunci independensi tersebut bukan hanya tertuju dari bagaimana tekanan dari luar diri hakimnya sendiri agar putusannya netral, tetapi juga independensi yang diperluas dari sebuah aturan yang mengatur diri hakim itu sendiri. Hakim tidak dapat disamakan dengan pegawai Aparatur Sipil Negara, sebab kedudukan hakim berbeda. Penempatan inilah yang belum diatur secara spesifik dalam negara Indonesia. Dapat dikatakan bahwa cita-cita tersebut masih menjadi utang konstitusi negeri ini jika dibandingkan dengan aparat penegak hukum lainnya yang sudah memiliki legalitas profesinya masing-masing seperti Jaksa, Polisi dan Pengacara DOI: 10.15408/jch.v4i1.2621
Ferias de agro-biodiversidad cubanas: vía para la selección de variedades de tomate.
Authors: Moya-López Carlos Celedonia , Orozco-Crespo Erick , Mesa-Fleitas María Elena 
Published: June 2016

<p class="Resumen"><span class="negrita char-style-override-4">El objetivo de este trabajo fue determinar en ferias de agro-biodiversidad el aporte de los agricultores en la selección de variedades de tomate (</span><span class="italica">Solanum lycopersicon</span><span class="negrita char-style-override-4"> L.) mejor adaptadas a las características de una localidad o sistema productivo específico. La investigación se efectuó en el Instituto Nacional de Ciencias Agrícolas, San José de Las Lajas, Cuba, en la campaña 2008-2009, siguiendo los métodos tradicionales para la evaluación de variedades; posteriormente, en una feria de agro biodiversidad en el municipio Batabanó, campaña 2010-2011, se tuvieron en cuenta los criterios de los productores sobre las variedades estudiadas. La evaluación estadística se centró en el análisis descriptivo de las variables, análisis de varianza, formación de conglomerados y uso de tablas de contingencia. Los resultados del ensayo comparativo se cotejaron con los de la feria de agro-biodiversidad. Los productores para discriminar las variedades, no solo tuvieron en cuenta las variables relacionadas con el rendimiento, sino que consideraron otras relacionadas con su experiencia en el cultivo y la preferencia personal.</span></p><div><span class="negrita char-style-override-4"><br /></span></div>