bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Role of Demographics and Psychological Variables in Internet Addiction
Authors: Ainin Sulaiman , Jaafar Noor Ismawati , Ashraf Muhammad , Parveen Farzana 
Published: September 2016

Background and Aim: In today’s fast changing world, the Internet plays a major role in people’s lives. Apart from its benefits, the Internet also has serious negative consequences which include the issue of Internet addiction. This study explores the role of demographics (e.g., age, gender, and occupational position) in relation to Internet addiction. In addition, the influence of individual psychological variables (loneliness, shyness, and proactive personality) on Internet addiction was also examined. Methods: A structured questionnaire consisting of items representing loneliness, shyness, proactiveness, Internet addiction, and demographics was used to collect the data from 1,000 working adults in selected organizations. Chi-square tests were used to investigate the effect of gender, age, and occupational positions on Internet addiction. The influence of variables such as loneliness, shyness, and proactiveness on Internet addiction was analyzed using partial least squares structural equation modeling (PLS-SEM). Results: The results demonstrated no significant differences in terms of Internet addiction between the genders. However, significant differences were found in Internet addiction depending on age and occupational positions. The study also found positive relationship between loneliness, shyness, proactiveness, and Internet addiction. Conclusion: The findings of this study add empirical evidence to the existing literature in respect of the correlation between age, gender, occupational position, psychological characteristics (loneliness, shyness, and proactiveness), and Internet addiction.
Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit
Authors: Chen Aileen , Loquias Erwin J. , Roshan Ramesh , Levene Richard , Zelhof Raymond , Hickey Terry , Cooney Gail Austin , Gonzalez Faustino 
Published: September 2016

Background: Diphenhydramine (DPH) is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions. However, many hospice patients are unable to take oral medications and/or do not have IV access. Moreover, topical administration has a relatively slow rate of absorption. For this reason, in the hospice setting it is not uncommon for diphenhydramine to be administered via the subcutaneous (SC) route secondary to its ease of access, low infection rates and its low levels of discomfort. In contrast, outside the hospice setting, subcutaneous DPH has not been widely used, primarily because of a handful of case reports published in the 1990’s that report skin necrosis following subcutaneous administration of DPH for local anesthesia. Since these early case reports, however, there has been very little in the way of research to examine this further. The aim of this study is to provide objective data concerning the safe use of subcutaneous diphenhydramine, as part of our efforts to improve upon safe practices in our organization. Methods: This is a retrospective review of records from 6 of our inpatient hospice units obtained from our pharmacy database for patients who received at least one subcutaneous injection of diphenhydramine between 2012-2015. Selected patients were then subsequently screened for post-administration skin necrosis, as recorded in our quality assurance database during the same time period. Results: A total of 648 diphenhydramine subcutaneous injections were administered in109 individual patients. None of the patients were reported to have an adverse cutaneous reaction. Conclusions: This retrospective review demonstrates that subcutaneous diphenhydramine injection is a safe alternative to oral and other parenteral routes, and may be particularly valuable in terminally ill patients, who are often unable to swallow and are without IV access.
The Knowing–Doing Gap in Advance Directives in Asian Americans: The Role of Education and Acculturation
Authors: Jang Yuri , Park Nan Sook , Chiriboga David A. , Radhakrishnan Kavita , Kim Miyong T. 
Published: September 2016

Objectives:The purposes of the present study were (1) to explore the completion rate of advance directives (ADs) in a sample of Asian Americans and (2) to examine the direct and moderating effects of knowledge of AD, education, and acculturation in predicting AD completion. Education and acculturation were conceptualized as moderators in the link between knowledge and completion of ADs.Methods:Using data from 2609 participants in the 2015 Asian American Quality of Life survey (aged 18-98), logistic regression analyses on AD completion were conducted, testing both direct and moderating effects.Results:The overall AD completion rate in sample was about 12%. The AD knowledge and acculturation independently predicted AD completion. No direct effect of education was found; however, it interacted with AD knowledge. The AD knowledge was more likely to be translated into completion in the group with higher education.Conclusions:The AD completion rate observed in the present sample of Asian Americans was much lower than that of the US general population (26%-36%). The interactive role of education helps to explain the gap between AD knowledge and completion and suggests intervention strategies.
“I Walked into the Industry for Survival and Came Out of a Closet”
Authors: Matthen Premala , Lyons Tara , Taylor Matthew , Jennex James , Anderson Solanna , Jollimore Jody , Shannon Kate 
Published: September 2016

Background/Objectives: This article seeks to examine how gender and sexual identities shape sex work experiences among men, two spirit, and/or trans people in Vancouver. Methods: In-depth, semistructured interviews were conducted with men and trans people in Metro Vancouver from Community Health Assessment of Men Who Purchase and Sell Sex. An intersectional critical feminist perspective guided the thematic analysis of interview transcripts, and ATLAS.ti 7 was used to manage data analysis. Results: Three themes emerged from the data: (1) the diversity of sexual and gender identities among sex workers and clients, (2) the expression and exploration of sexual and gender identities through sex work, and (3) the migration of sexual and gender minorities to urban centers to escape discrimination in their places of origin. Discussion: These findings complicate existing narratives of sex work, demonstrating the need for policies and services that reflect the diversity of sex work experiences.
Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib
Authors: Lacroix Jean-Philip , Wang Beatrice 
Published: September 2016

Background: Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with vemurafenib, dabrafenib is a more recent BRAF inhibitor approved by the Food and Drug Administration in May 2013 for metastatic melanoma; fewer data are available in the current literature regarding cutaneous toxicity. Objectives: We sought to present additional cutaneous side effects of dabrafenib and trametinib and follow their evolution and management. Methods: We carried out a prospective study of 14 patients treated with dabrafenib alone or with trametinib. Patients were followed every 4 weeks, and we collected detailed cutaneous symptoms, photos, and biopsy specimens. Results: All patients presented with at least 1 adverse skin reaction. The mean duration of treatment was 24 weeks. The most common adverse effect was papillomas (7/14), followed by palmoplantar hyperkeratosis (5/14), alopecia (5/14), and seborrheic dermatitis-like eruption (2/14). Three patients who received trametinib developed an acneiform eruption (3/5). One patient developed a keratoacanthoma-like squamous cell carcinoma. Side effects presented as early as 2 weeks after starting therapy, with a mean time of onset of 9 weeks. Conclusion: Selective BRAF inhibitor dabrafenib and MEK inhibitor trametinib are associated with multiple skin adverse effects. Given their recent approval and the potential for malignant lesions to develop on treatment, awareness of potential adverse effects and their management is necessary.
Institutional Cost of Unplanned 30-Day Readmission Following Open and Endovascular Surgery
Authors: Gracon Adam S. A. , Liang Tiffany W. , Easterday Thomas S. , Weber Daniel J. , Butler James , Slaven James E. , Lemmon Gary W. , Motaganahalli Raghu L. 
Published: September 2016

Background: Vascular surgical patients have a high rate of readmission, and the cost of readmission for these patients has not been described. Herein, we characterize and compare institutional index hospitalization and 30-day readmission cost following open and endovascular vascular procedures. Methods: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify inpatient open and endovascular procedures at a single institution, from January 2011 through June 2012. Variable and fixed costs for index hospitalization and unplanned 30-day readmissions were obtained using SAP BusinessObjects. Patient characteristics and outcome variables were analyzed using Student t tests or Wilcoxon rank-sum nonparametric tests for continuous variables and Fisher exact tests for categorical variables. Results: One thousand twenty-six inpatient procedures were included in the analysis. There were 605 (59%) open and 421 (41%) endovascular procedures with a 30-day unplanned readmission rate of 16.9% and 17.8%, respectively ( P = .679). The mean index hospitalization costs for open and endovascular procedures were US$27 653 and US$23 999, respectively ( P = .146). The mean costs for 30-day unplanned readmission for open and endovascular procedures were US$19 117 and US$17 887, respectively ( P = .635). Among open procedures, the mean cost for patients not readmitted was US$28 321 compared to US$31 115 for those readmitted ( P = .003). Among endovascular procedures, the mean cost for patients not readmitted was US$26 908 compared to US$32 262 for those readmitted ( P = .028). Conclusion: The cost of index hospitalization and 30-day unplanned readmission are similar for open and endovascular procedures. Readmitted patients had a higher mean index hospitalization cost irrespective of open or endovascular procedure.
Comparative Outcomes of Ultrasound-Assisted Thrombolysis and Standard Catheter-Directed Thrombolysis in the Treatment of Acute Pulmonary Embolism
Authors: Liang Nathan L. , Avgerinos Efthymios D. , Marone Luke K. , Singh Michael J. , Makaroun Michel S. , Chaer Rabih A. 
Published: September 2016

Objectives: The objective of this study was to compare the outcomes of patients undergoing ultrasound-accelerated thrombolysis (USAT) and standard catheter-directed thrombolysis (CDT) for the treatment of acute pulmonary embolism (PE). Methods: The records of all patients in our institution having undergone CDT or USAT for massive or submassive PE from 2009 to 2014 were retrospectively reviewed. Standard statistical methods were used to compare characteristics and to assess for longitudinal change in outcomes. Results: Sixty-three patients, 27 CDT and 36 USAT, were treated for massive (12.7%) or submassive (87.3%) PE. Of which, 96.8% were treated for bilateral PE. Baseline patient characteristics did not differ between the 2 treatment groups. There was no difference in total dose of lytic administered (CDT: 23.2 ± 13.7 mg; USAT: 27.5 ± 12.9 mg; P = .2). Two patients in the CDT and 1 in the USAT groups required conversion to surgical thrombectomy (CDT: 7.4%; USAT: 2.8%; P = .6). Rates of major and minor bleeding complications (CDT: 11.0%; USAT: 13.9%; P = .8) did not differ significantly between the CDT and USAT groups. Estimated survival at 90 days was 92% for CDT and 93% for USAT and 82% at 1 year for both groups ( P = .8). All echocardiographic parameters improved significantly from baseline to 1-year follow-up, but quantitative improvement did not differ between groups. Conclusion: This study suggests no statistical differences in clinical and hemodynamic outcomes or procedural complication rates between USAT and standard CDT for the treatment of acute PE. Prospective studies are needed to further evaluate comparative and cost-effectiveness of different interventions for acute massive and submassive PE.
Moyamoya vasculopathy – Patient demographics and characteristics in the Finnish population
Authors: Saarela Marika , Mustanoja Satu , Pekkola Johanna , Tyni Tiina , Hernesniemi Juha , Kivipelto Leena , Tatlisumak Turgut 
Published: September 2016

Background and purpose Moyamoya vasculopathy, a rare steno-occlusive progressive cerebrovascular disorder, has not been thoroughly studied in Caucasian populations. We established a registry of Finnish patients treated at the Helsinki University Hospital, to collect and report demographic and clinical data. Methods We collected data both retrospectively and prospectively from all the patients with a moyamoya vasculopathy referred to our hospital between January 1987 and December 2014. All patients underwent a neurological outpatient clinic visit. Results We diagnosed 61 patients (50 females, 10 children) with moyamoya vasculopathy. The mean age at the disease-onset was 31.5 ± 17.9 years. The two most common presenting symptoms were ischemic stroke (n = 31) and hemorrhage (n = 8). Forty-four percent underwent revascularization surgery, and 70% were prescribed antithrombotic treatment. Conclusions The results support in part the Western phenotype of the disease considering the later presentation and larger female predominance compared to the Asian moyamoya vasculopathy reports. However, the proportion of ischemic strokes and hemorrhagic strokes is closer to Japanese population than German population. The absence of familial cases points to a different genetic profile in the Finnish patients.
Hand impairment and functional ability: A matched case comparison study between people with rheumatoid arthritis and healthy controls
Authors: Packer Melissa , Williams Mark , Samuel Dinesh , Adams Jo 
Published: September 2016

Introduction The aim of this study was to compare hand impairment and function in a cohort of patients with rheumatoid arthritis and matched healthy participants. Methods A matched case comparison research design comparing hand impairment and functional ability between patients with rheumatoid arthritis and healthy participants (males or females, aged ≥ 50 years). Functional ability was assessed using the Michigan Hand Questionnaire, power and pinch grip strength and the nine-hole peg test. Results A total of 100 participants (50 patients with rheumatoid arthritis and 50 matched healthy participants) were recruited. Patients with rheumatoid arthritis reported significantly lower overall hand function, activities of daily living, work, aesthetics, satisfaction ( p < 0.001) and significantly higher pain scores when compared with healthy controls. The patients with rheumatoid arthritis had significantly lower maximum power and pinch grip strength in both left and right hands ( p < 0.001) when compared with healthy controls. The rheumatoid arthritis group took significantly longer to complete the nine-hole peg test using both right and left hands compared with healthy controls ( p < 0.001, respectively). Additionally, in rheumatoid arthritis patients, a significant moderate, positive correlation between power grip strength and activities of daily living (r = 0.584, n = 50, p < 0.01) and a weak-to-moderate, significant negative correlation between power grip strength and pain (r = −0.314, n = 50, p < 0.05) were reported. Conclusion Despite the recent substantial improvement of drug therapy and disease control, the functional impact of rheumatoid arthritis on hand pain and function remains significant.
Impact of Platelet-Rich Plasma on Arthroscopic Repair of Small- to Medium-Sized Rotator Cuff Tears
Authors: Holtby Richard , Christakis Monique , Maman Eran , MacDermid Joy C. , Dwyer Tim , Athwal George S. , Faber Kenneth , Theodoropoulos John , Woodhouse Linda J. , Razmjou Helen 
Published: September 2016

Background: Increased interest in using platelet-rich plasma (PRP) as an augment to rotator cuff repair warrants further investigation, particularly in smaller rotator cuff tears. Purpose: To examine the effectiveness of PRP application in improving perioperative pain and function and promoting healing at 6 months after arthroscopic repair of small- or medium-sized rotator cuff tears. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a double-blinded randomized controlled trial of patients undergoing arthroscopic repair of partial- or full-thickness rotator cuff tears of up to 3 cm who were observed for 6 months. Patients were randomized to either repair and PRP application (study group) or repair only (control group) groups. The patient-oriented outcome measures utilized were the visual analog scale (VAS), the Short Western Ontario Rotator Cuff Index (ShortWORC), the American Shoulder and Elbow Surgeons (ASES) form, and the Constant-Murley Score (CMS). Range of motion (ROM) and inflammatory and coagulation markers were measured before and after surgery. Magnetic resonance imaging was used at 6 months to assess retear and fatty infiltration rate. Results: Eighty-two patients (41 males) with a mean age of 59 ± 8 years were enrolled; 41 patients were included in each group. Both the PRP and control groups showed a significant improvement in their pain level based on the VAS within the first 30 days ( P < .0001), with the PRP group reporting less pain than the control group ( P = .012), which was clinically significantly different from days 8 through 11. The PRP group reported taking less painkillers ( P = .026) than the control group within the first 30 days. All outcome measure scores and ROM improved significantly after surgery ( P < .0001), with no between-group differences. No differences were observed between groups in inflammatory or coagulation marker test results ( P > .05), retear (14% vs 18% full retear; P = .44), or fatty infiltration rate ( P = .08). Conclusion: The PRP biological augmentation for repair of small- to medium-sized rotator cuff tears has a short-term effect on perioperative pain without any significant impact on patient-oriented outcome measures or structural integrity of the repair compared with control group.
Respective contributions of single and compound granule fusion to secretion by activated platelets
Authors: Eckly Anita , Rinckel Jean-Yves , Proamer Fabienne , Ulas Neslihan , Joshi Smita , Whiteheart Sidney W. , Gachet Christian 
Published: September 2016

Key Points
Weak stimulation favors the fusion of single granules with the platelet surface and stronger stimulation induces granule-granule fusion. VAMP8 participates in single and compound exocytosis.
Reduction strategies for hierarchical multi-label classification in protein function prediction
Authors: Cerri Ricardo , Barros Rodrigo C. , P. L. F. de Carvalho André C. , Jin Yaochu 
Published: September 2016

Abstract
Background
Hierarchical Multi-Label Classification is a classification task where the classes to be predicted are hierarchically organized. Each instance can be assigned to classes belonging to more than one path in the hierarchy. This scenario is typically found in protein function prediction, considering that each protein may perform many functions, which can be further specialized into sub-functions. We present a new hierarchical multi-label classification method based on multiple neural networks for the task of protein function prediction. A set of neural networks are incrementally training, each being responsible for the prediction of the classes belonging to a given level.

Results
The method proposed here is an extension of our previous work. Here we use the neural network output of a level to complement the feature vectors used as input to train the neural network in the next level. We experimentally compare this novel method with several other reduction strategies, showing that it obtains the best predictive performance. Empirical results also show that the proposed method achieves better or comparable predictive performance when compared with state-of-the-art methods for hierarchical multi-label classification in the context of protein function prediction.

Conclusions
The experiments showed that using the output in one level as input to the next level contributed to better classification results. We believe the method was able to learn the relationships between the protein functions during training, and this information was useful for classification. We also identified in which functional classes our method performed better.
Between Usury and the “Spirit of Commerce”
Authors: Trivellato Francesca 
Published: September 2016

AbstractBy bringing French history and Jewish history into dialogue, this article intervenes in the vast scholarship on the relationship between commerce and toleration in eighteenth-century French thought. It focuses on the place of Jews in Montesquieu's ideas about doux commerce and explores the legacy of Montesquieu's views on the debate on Jewish emancipation in the 1770s and 1780s. It traces the survival and adaptation of the medieval trope of the Jewish usurer in a variety of discourses, ranging from irenic images of commercial cosmopolitanism to representations of Jewish moneylending marshaled by radical advocates of Jewish “regeneration.” The article concludes by showing that in 1790–91 the doctrine of doux commerce did not provide a consistent argument in favor of civic and political equality even though commercial practices and policies in the French Southwest had favored the integration of Jews during the Old Regime.En mettant l'histoire française et l'histoire juive en dialogue, cet article fait une contribution aux études sur le rapport entre commerce et tolérance dans la pensée du dix-huitième siècle. Il se penche sur la place des juifs dans la doctrine du doux commerce de Montesquieu et trace l'influence des idées de Montesquieu sur le débat à propos de l'émancipation des juifs qui se déroula aux années 1770 et 1780. Il montre la persistance ainsi que l'évolution du trope médiéval de l'usurier juif dans plusieurs discours, tels que les représentations favorables au cosmopolitisme commercial ou les diabolisations des prêteurs juifs mobilisées par les promoteurs de la « régénération ». Finalement, l'article montre qu'en 1790–91, la doctrine du doux commerce n'avait pas établi de raisonnement cohérent en faveur de l'égalité civique et politique des juifs bien que le commerce ait favorisé l'intégration des juifs du Sud-Ouest pendant l'ancien régime.