bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: SYNTHESIS OF ANALOGS OF BRADYKININ WITH REPLACEMENT OF THE ARGININE RESIDUES BY 4‐GUANIDINOPHENYL‐L‐ALANINE
Authors: MOORE S. , LAW H. D. , BRUNDISH D. E. , ELLIOTT D. F. , WADE R. 
Published: April 2016

AbstractDie Analogen (Ilc), (Va) und (Vb) von Bradykinin (IIa) werden synthetisiert: (IIc) wird durch schrittweisen Aufbau (übliche Methoden) ausgehend von der Aminosäure (I) ‐ entsprechend der Synthese von (IIa) selbst ‐ gewonnen [nach Schutzgruppenabspaltung aus dem Derivat (IIb)]; (Va) ist durch Kondensation des (vom N‐terminalen Ende her aufgebauten) Octapeptides (III) mit (I) (nach Schutzgruppenabspaltung) erhältlich, und (Vb) wird durch Kondensation des IRQ Arginin‐Derivats (IV) mit (III) erhalten.
ChemInform Abstract: DIHYDROTHIAZINE RING‐OPENING REACTIONS IN 2‐ALKOXYCEPHALOSPORIN COMPOUNDS
Authors: YOSHIDA A. , OIDA S. , OHKI E. 
Published: April 2016

AbstractUmsetzung von 7β‐Benzamido‐3‐methyl‐3‐cephem‐4‐carbonsäuremethylester (I) mit tert.‐Butylhypochlorit in Methylenchlorid/Äthanol ergibt nach chromatographischer Aufarbeitung das 2a‐Äthoxy‐3‐cephem (II), aus dem durch Oxidation mit m‐Chlorperbenzoesäure das Oxid (IIIa) erhalten wird.
ChemInform Abstract: ORALLY ACTIVE ESTERS OF CEPHALOSPORIN ANTIBIOTICS. SYNTHESIS AND BIOLOGICAL PROPERTIES OF ACYLOXYMETHYL ESTERS OF 7‐(D‐2‐AMINO‐2‐PHENYLACETAMIDO)‐3‐(5‐METHYL‐(1,3,4‐THIADIAZOL‐2‐YL)THIOMETHYL)‐3‐CEPHEM‐4‐CARBOXYLIC ACID
Authors: WHEELER W. J. , WRIGHT W. E. , LINE V. D. , FROGGE J. A. 
Published: April 2016

AbstractAus dem freien Amino‐Derivat (Ia) erhält man über das Verfahren der gemischten Anhydride das Acylierungsprodukt (Ib), aus dem die geschützten Ester (II) sowie die freien Amine (III) erhalten werden können.
eHRM adoption in emerging economies: The case of subsidiaries of multinational corporations in Indonesia
Authors: Bondarouk Tanya , Schilling Dustin , Ruël Huub 
Published: April 2016

AbstractElectronic HRM (eHRM) is assumed to strengthen the position of HRM as a business partner by promising strategic benefits. Empirical support for this assumption, however, mostly comes from studies conducted in developed economies. Yet eHRM adoption in the emerging economy context remains poorly understood as is how eHRM can result in strategic benefits. We argue that the difference between an emerging economy compared to that of a developed economy affects the adoption of eHRM in multinational corporation (MNC) subsidiaries. In order to investigate which extrinsic factors of a firm in an emerging economy context play a role in the adoption of eHRM, we conducted semistructured interviews in 11 subsidiaries in Indonesia. We found that headquarters’ influence and the available resources have a strong influence on eHRM adoption in Indonesia. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd.
A stochastic performance model for pipelined Krylov methods
Authors: Morgan Hannah , Knepley Matthew G. , Sanan Patrick , Scott L. Ridgway 
Published: April 2016

SummaryPipelined Krylov methods seek to ameliorate the latency due to inner products necessary for projection by overlapping it with the computation associated with sparse matrix‐vector multiplication. We clarify a folk theorem that this can only result in a speedup of 2× over the naive implementation. Examining many repeated runs, we show that stochastic noise also contributes to the latency, and we model this using an analytical probability distribution. Our analysis shows that speedups greater than 2× are possible with these algorithms. Copyright © 2016 John Wiley & Sons, Ltd.
An approach of performance comparisons with OpenMP and CUDA parallel programming on multicore systems
Authors: Chang Chih‐Hung , Lu Chih‐Wei , Yang Chao‐Tung , Chang Tzu‐Chieh 
Published: April 2016

SummaryIn the past, the tenacious semiconductor problems of operating temperature and power consumption limited the performance growth for single‐core microprocessors. Microprocessor vendors hence adopt the multicore chip organizations with parallel processing because the new technology promises faster and lower power needed. In a short time, this trend floods first the development of CPU, then also the other peripherals like GPU. Modern GPUs are very efficient in manipulating computer graphics, and their highly parallel structure makes them even more effective than general‐purpose CPUs for a range of graphical complex algorithms. However, technology of multicore processor brought revolution and unavoidable collision to the programming personnel. Multicore processor has high performance; however, parallel processing brings not only the opportunity but also a challenge. The issue of efficiency and the way how programmer or compiler parallelizes the software explicitly are the keys that enhance the performance on multicore chip. In this paper, we propose a parallel programming approach using hybrid CUDA, OpenMP, and MPI programming. There would be two verificational experiments presented in the paper. In the first, we would verify the availability and correctness of the auto‐parallel tools, and discuss the performance issues on CPU, GPU, and embedded system. In the second, we would verify how the hybrid programming could surely improve performance. Copyright © 2016 John Wiley & Sons, Ltd.
Photometric Detection of Nitric Oxide Using a Dissolved Iron(III) Corrole as a Sensitizer
Authors: Fischer Stefan , Vestfrid Jenya , Mahammed Atif , Herrmann‐Westendorf Felix , Schulz Martin , Müller Jürgen , Kiesewetter Olaf , Dietzek Benjamin , Gross Zeev , Presselt Martin 
Published: April 2016

AbstractInvited for this month's cover are the collaborating groups of Dr. Martin Presselt from Friedrich Schiller University Jena, Germany and Prof. Zeev Gross from Technion–Israel Institute of Technology, Haifa, Israel. The cover picture shows a human jogging, which can potentially triggering asthma or heart attacks. These attacks involve blood‐vessel contraction and are therefore typically indicated by an increase in NO concentration in the exhaled air. Read the full text of the article at 10.1002/cplu.201500553.
Theoretical Studies of Oxygen Reactivity of Free‐Standing and Supported Boron‐Doped Graphene
Authors: Di Valentin Cristiana , Ferrighi Lara , Fazio Gianluca 
Published: April 2016

AbstractGraphene inertness towards chemical reactivity can be considered as an accepted postulate by the research community. This limit has been recently overcome by chemically and physically modifying graphene through non‐metal doping or interfacing with acceptor/donor materials (metals or semiconductors). As a result, outstanding performances as catalytic, electrocatalytic, and photocatalytic material have been observed. In this critical Review we report computational work performed, by our group, on the reactivity of free‐standing, metal‐ and semiconductor‐supported B‐doped graphene towards oxygen, which is at the basis of extremely important energy‐related chemical processes, such as the oxygen reduction reaction. It appears that a combination of doping and interfacing approaches for the activation of graphene can open unconventional and unprecedented reaction paths, thus boosting the potential of modified graphene in many chemical applications.
Studies on the Enantioselective Kinugasa Reaction: Efficient Synthesis of β‐Lactams Catalyzed by N‐PINAP/CuX Complexes
Authors: Wolosewicz Karol , Michalak Michał , Adamek Jakub , Furman Bartłomiej 
Published: April 2016

AbstractCatalytic enantioselective Kinugasa reactions between acyclic and, for the first time, cyclic nitrones and terminal alkynes are described herein. A catalytic amount of the readily available PINAP/CuX complexes, generated in situ, efficiently catalyzed the Kinugasa reactions, leading to a series of β‐lactams with good enantioselectivities and moderate diastereoselectivities and yields. A broad range of nitrones and terminal alkynes, including the seldom reported alkyl‐substituted alkynes, were tolerated under the reaction conditions. Further investigations proved that the PINAP/CuX catalytic system enabled the synthesis of monobactams on the gram scale (without loss of stereoselectivity and yield) and also both enantiomers by the appropriate choice of readily available atropisomeric N‐PINAP ligands.
Highly Active and Thermally Stable Supported Pd@SiO2 Core–Shell Catalyst for Catalytic Methane Combustion
Authors: Pi Dong , Li Wen Zhi , Lin Qi Zhao , Huang Qi Fu , Hu Hui Qing , Shao Chun Yu 
Published: April 2016

AbstractA series of Pd‐based core–shell catalysts (Pd@SiO2, Pd@CeO2, and Pd@ZrO2) supported on Si‐modified Al2O3 were prepared for the catalytic combustion of lean methane. Pd@SiO2 exhibited slightly lower catalytic activity than Pd@CeO2 and higher catalytic activity than Pd@ZrO2 in dry conditions; however, Pd@SiO2 had the highest catalytic activity among the three catalysts in the presence of high concentrations of water vapor. Furthermore, the Pd@SiO2 catalyst showed good thermal stability and resistivity to water poisoning. CO chemisorption and TEM results demonstrated that the core–shell structure could help in the stabilization of the active phase compared to the uncoated Pd/Si‐Al2O3 catalyst. XRD and X‐ray photoelectron spectroscopy results indicated that a balanced mixed phase of PdOx/Pd0 is the main active phase of these Pd‐based catalysts.
Enhancement of the Efficiency and Selectivity for Carbon Dioxide Electroreduction to Fuels on Tailored Copper Catalyst Architectures
Authors: Bevilacqua Manuela , Filippi Jonathan , Folliero Maria , Lavacchi Alessandro , Miller Hamish A. , Marchionni Andrea , Vizza Francesco 
Published: April 2016

AbstractThe electroreduction of CO2 is one of the most promising strategies for the production of fuels, energy vectors, and chemicals from CO2. Recently, we have described the realization of an electrochemical reactor based on the use of a Cu cathode for the CO2 electroreduction reaction. Here, three Cu electrodes were prepared by different techniques that generate different surface structures and morphologies. These three Cu cathodes, employed in the electrolysis cell, are compared in terms of Faradaic efficiency (FE) and product selectivity to a reference Cu foil electrode. The higher active surface area of these samples produced an improved total FE versus the Cu smooth plate. In terms of product selectivity, Cu electroplating onto a Cu foil enhanced HCOOK production strongly; the electrofaceting treatment of the Cu foil drove selectivity towards the production of CH4. In the third electrode, the deposition of Cu onto carbon cloth favors the formation of C2H4.
Hydrate‐Based Gas Separation for Methane Recovery from Coal Mine Gas using Tetrahydrofuran
Authors: Zhao Jianzhong , Zhao Yangsheng , Liang Weiguo 
Published: April 2016

AbstractCoal mine methane (CMM) gas is an unconventional natural gas that can be used as a clean supplementary energy resource when the methane is enriched. In this work, a new technology for separating methane from low‐concentration CMM gas was investigated using gas hydrate formation in the presence of tetrahydrofuran (THF). The concentration of THF was fixed at 19 %, the initial pressure fixed at 0.3 MPa, 0.5 MPa, 0.8 MPa, 1.0 MPa, respectively, and the temperature was maintained at 278.15 K. The results indicated that gas hydrate formation and the separation of CH4 can be easily achieved at 0.3–1.0 MPa in THF solution. It was determined that the hydrate‐based separation process for CH4 recovery from the CMM gas mixture performed better at medium and low initial pressures. The separation factor decreased from 9.5451 to 7.1834 as the reaction pressure rose from 0.3 to 1.0 MPa.
Trends and multi‐annual variability of water temperatures in the river Danube, Serbia
Authors: Basarin Biljana , Lukić Tin , Pavić Dragoslav , Wilby Robert L. 
Published: April 2016

AbstractThe relationship between air (Ta) and water temperature (Tw) is very important because it shows how the temperature of a water body might respond to future changes in surface Ta. Mean monthly Tw records of three gauging stations (Bezdan, Bogojevo i Veliko Gradište) were analysed alongside mean monthly discharge (Q) for the same stations. Additionally, Ta series from two meteorological stations (Sombor and Veliko Gradište) were correlated with Tw variations over the period 1950–2012. Locally weighted scatter point smoothing (LOWESS) was used to investigate long‐term trends in the raw data, alongside the Mann–Kendall (MK) trend test. Trend significance was established using Yue–Pilon's pre‐whitening approaches to determine trends in climate data. Also, the rescaled adjusted partial sums (RAPS) method was used to detect dates of possible changes in the time series. Statistically significant warming trends were observed for annual and seasonal minimum and maximum Tw at all investigated sites. The strongest warming was observed at Bogojevo gauging station for seasonal maximum Tw, with +0.05 °C per year on average. RAPS established that the trend began in the 1980s. This behaviour is linked to climate patterns in the North and East Atlantic which determine the amount of heat advected onto mainland Europe. Statistically significant correlations were found for all Tw on an annual basis. Overall, the strongest correlations (p < 0.01) between Tw residuals and the North Atlantic Oscillation (NAO) were recorded for the winter period. These findings suggest possible predictability of Tw over seasonal time‐scales. Copyright © 2016 John Wiley & Sons, Ltd.
Altered expression of Butyrophilin (BTN) and BTN‐like (BTNL) genes in intestinal inflammation and colon cancer
Authors: Lebrero‐Fernández Cristina , Wenzel Ulf Alexander , Akeus Paulina , Wang Ying , Strid Hans , Simrén Magnus , Gustavsson Bengt , Börjesson Lars G. , Cardell Susanna L. , Öhman Lena , Quiding‐Järbrink Marianne , Bas‐Forsberg Anna 
Published: April 2016

AbstractSeveral Butyrophilin (BTN) and Btn‐like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine BTN and BTNL genes in conditions associated with intestinal inflammation and cancer. Using real‐time PCR, expression of human BTN and BTNL genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine Btn and Btnl genes was examined in mouse models of spontaneous colitis (Muc2−/−) and intestinal tumorigenesis (ApcMin/+). Our analysis indicates a strong association of several of the human genes with ulcerative colitis and colon cancer; while especially BTN1A1, BTN2A2, BTN3A3, and BTNL8 were significantly altered in inflammation, colonic tumors exhibited significantly decreased levels of BTNL2, BTNL3, BTNL8, and BTNL9 as compared to unaffected tissue. Colonic inflammation in Muc2−/− mice significantly down‐regulated the expression of particularly Btnl1, Btnl4, and Btnl6 mRNA, and intestinal polyps derived from ApcMin/+ mice displayed altered levels of Btn1a1, Btn2a2, and Btnl1 transcripts. Thus, our data present an association of BTN and BTNL genes with intestinal inflammation and cancer and represent a valuable resource for further studies of this gene family.
Interceptor Drainage Modelling to Manage High Groundwater Table on the Abyek Plain, Iran
Authors: Ghorbani Karim , Lee Teang Shui , Wayayok Aimrun , Boroomand Nasab Saeed 
Published: April 2016

AbstractHigh groundwater tables and soil salinity are a serious threat to agricultural areas, especially on the Abyek Plain, Iran. An interceptor drainage system was installed to lower the groundwater head and control soil salinity. Simulation is an appropriate approach to investigate possible groundwater behaviour in future conditions and to explore suitable designs for implementation. Ninety‐nine observation wells were installed around the interceptor drainage system in the Abyek Plain to monitor groundwater movement and salinity changes. Groundwater table fluctuation was measured monthly for 3 years from December 2010 until January 2014. A MODFLOW model was calibrated for the study area using the data measured through the observation wells. Assessment of the measured values indicated that the groundwater head was lowered within the 3 years due to the installation of the system. A calibrated model was applied to predict the future conditions of groundwater levels and suggest proper designs. Groundwater level drawdowns were predicted at approximately 1.3 and 1.5 m for August 2018 and August 2025, respectively. The results also revealed that with the installation of additional parallel interceptor drainage at a distance of 1000 m from the existing drainage, the groundwater table could be lowered in a large area of the plain. Copyright © 2016 John Wiley & Sons, Ltd.
A surface plasmon resonance system for the underwater detection of domoic acid
Authors: Colas Florent , Crassous Marie‐Pierre , Laurent Sebastien , Litaker Richard W. , Rinnert Emmanuel , Le Gall Erwan , Lunven Michel , Delauney Laurent , Compère Chantal 
Published: April 2016

AbstractOver the past decade Surface Plasmon Resonance (SPR) techniques have been applied to the measurement of numerous analytes. In this article, an SPR biosensor system deployed from an oceanographic vessel was used to measure dissolved domoic acid (DA), a common and harmful phycotoxin produced by certain microalgae species belonging to the genus Pseudo‐nitzschia. During the biosensor deployment, concentrations of Pseudo‐nitzschia cells were very low over the study area and measured DA concentrations were below detection. However, the in situ operational detection limit of the system was established using calibrated seawater solutions spiked with DA. The system could detect the toxin at concentrations as low as 0.1 ng mL−1 and presented a linear dynamic range from 0.1 ng mL−1 to 2.0 ng mL−1. This sensor showed promise for in situ detection of DA.
Hexagonal gradient scheme with RF spoiling improves spoiling performance for high‐flip‐angle fast gradient echo imaging
Authors: Hess Aaron T. , Robson Matthew D. 
Published: April 2016

PurposeTo present a framework in which time‐varying gradients are applied with RF spoiling to reduce unwanted signal, particularly at high flip angles.MethodsA time‐varying gradient spoiler scheme compatible with RF spoiling is defined, in which spoiler gradients cycle through the vertices of a hexagon, which we call hexagonal spoiling. The method is compared with a traditional constant spoiling gradient both in the transition to and in the steady state. Extended phase graph (EPG) simulations, phantom acquisitions, and in vivo images were used to assess the method.ResultsSimulations, phantom and in vivo experiments showed that unwanted signal was markedly reduced by employing hexagonal spoiling, both in the transition to and in the steady state. For adipose tissue at 1.5 Tesla, the unwanted signal in the steady state with a 60 ° flip angle was reduced from 22% with constant spoiling to 2% with hexagonal spoiling.ConclusionsA time‐varying gradient spoiler scheme that works with RF spoiling, called “hexagonal spoiling,” has been presented and found to offer improved spoiling over the traditional constant spoiling gradient. Magn Reson Med 77:1231–1237, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Pelvic floor muscle function, pelvic floor dysfunction and diastasis recti abdominis: Prospective cohort study
Authors: Bø Kari , Hilde Gunvor , Tennfjord Merete Kolberg , Sperstad Jorun Bakken , Engh Marie Ellstrøm 
Published: April 2016

AimsCompare vaginal resting pressure (VRP), pelvic floor muscle (PFM) strength, and endurance in women with and without diastasis recti abdominis at gestational week 21 and at 6 weeks, 6 months, and 12 months postpartum. Furthermore, to compare prevalence of urinary incontinence (UI) and pelvic organ prolapse (POP) in the two groups at the same assessment points.MethodsThis is a prospective cohort study following 300 nulliparous pregnant women giving birth at a public university hospital. VRP, PFM strength, and endurance were measured with vaginal manometry. ICIQ‐UI‐SF questionnaire and POP‐Q were used to assess UI and POP. Diastasis recti abdominis was diagnosed with palpation of  ≥2 fingerbreadths 4.5 cm above, at, or 4.5 cm below the umbilicus.ResultsAt gestational week 21 women with diastasis recti abdominis had statistically significant greater VRP (mean difference 3.06 cm H2O [95%CI: 0.70; 5.42]), PFM strength (mean difference 5.09 cm H2O [95%CI: 0.76; 9.42]) and PFM muscle endurance (mean difference 47.08 cm H2O sec [95%CI: 15.18; 78.99]) than women with no diastasis. There were no statistically significant differences between women with and without diastasis in any PFM variables at 6 weeks, 6 months, and 12 months postpartum. No significant difference was found in prevalence of UI in women with and without diastasis at any assessment points. Six weeks postpartum 15.9% of women without diastasis had POP versus 4.1% in the group with diastasis (P = 0.001).ConclusionsWomen with diastasis were not more likely to have weaker PFM or more UI or POP. Neurourol. Urodynam. 36:716–721, 2017. © 2016 Wiley Periodicals, Inc.
The IMI PROTECT project: purpose, organizational structure, and procedures
Authors: Reynolds Robert F. , Kurz Xavier , de Groot Mark C.H. , Schlienger Raymond G. , Grimaldi‐Bensouda Lamiae , Tcherny‐Lessenot Stephanie , Klungel Olaf H. 
Published: April 2016

AbstractThe Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium (PROTECT) initiative was a collaborative European project that sought to address limitations of current methods in the field of pharmacoepidemiology and pharmacovigilance. Initiated in 2009 and ending in 2015, PROTECT was part of the Innovative Medicines Initiative, a joint undertaking by the European Union and pharmaceutical industry. Thirty‐five partners including academics, regulators, small and medium enterprises, and European Federation of Pharmaceuticals Industries and Associations companies contributed to PROTECT. Two work packages within PROTECT implemented research examining the extent to which differences in the study design, methodology, and choice of data source can contribute to producing discrepant results from observational studies on drug safety. To evaluate the effect of these differences, the project applied different designs and analytic methodology for six drug–adverse event pairs across several electronic healthcare databases and registries. This papers introduces the organizational structure and procedures of PROTECT, including how drug–adverse event and data sources were selected, study design and analyses documents were developed, and results managed centrally. Copyright © 2016 John Wiley & Sons, Ltd.
Right‐side pulmonary agenesis with atrial septal defect in adult
Authors: Das Shukla Amitabh , Agrawal Neha , Chandra Alok , Anantha Shreenivasa , Chaudhary Abhinav 
Published: April 2016

AbstractPulmonary agenesis, a rare congenital condition, is incompatible with life when present bilateral, while unilateral agenesis is usually detected in infancy or early childhood. Rare asymptomatic patients may reach adulthood undiagnosed, with signs mimicking common conditions presenting as radiopaque hemithorax with ipsilateral mediastinal shift. Here, we describe a case of a young lady, with history of consanguinity, who presented with complaints, suggestive of lower respiratory tract infection, and was investigated and diagnosed to be a case of right‐side pulmonary agenesis with large ostium secondum atrial septal defect. Our present case emphasizes the importance of presence of pulmonary agenesis with cardiac congenital anomaly, remaining asymptomatic until adulthood, particularly in patients born of parents with consanguineous marriages.