bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular responses of seaweeds to biotic interactions: A systematic review
Authors: Lang Tomas , Cummins Scott F. , Paul Nicholas A. , Campbell Alexandra H. 
Published: October 2024

AbstractSeaweed farming is the single largest aquaculture commodity with >30 million tonnes produced each year. Furthermore, the restoration of lost seaweed forests is gaining significant momentum, particularly for kelps in warming temperate areas. Whether in aquaculture settings, following restoration practices, or in the wild, all seaweeds undergo biotic interactions with a diverse range of co‐occurring or cocultured organisms. To date, most research assessing such biotic interactions has focused on the response of the organism interacting with seaweeds, rather than on the seaweeds themselves. However, understanding how seaweeds respond to other organisms, particularly on a molecular scale, is crucial for optimizing outcomes of seaweed farming or restoration efforts and, potentially, also for the conservation of natural populations. In this systematic review, we assessed the molecular processes that seaweeds undergo during biotic interactions and propose priority areas for future research. Despite some insights into the response of seaweeds to biotic interactions, this review specifically highlights a lack of characterization of biomolecules involved in the response to chemical cues derived from interacting organisms (four studies in the last 20 years) and a predominant use of laboratory‐based experiments conducted under controlled conditions. Additionally, this review reveals that studies targeting metabolites (70%) are more common than those examining the role of genes (22%) and proteins (8%). To effectively inform seaweed aquaculture efforts, it will be crucial to conduct larger scale experiments simulating natural environments. Also, employing a holistic approach targeting genes and proteins would be beneficial to complement the relatively well‐established role of metabolites.
Risk‐based valuation of surveillance data in open environments: Methods application to a key shellfish aquaculture production region
Authors: Gustafson Lori , Remmenga Marta , Duncan Clara , Bliss Clayton , Bushek David , Carnegie Ryan B. , Giray Cem , Meyers Ted , Davis Katherine , Hartman Kathleen , Elston Ralph 
Published: October 2024

AbstractDisease freedom surveillance is challenging in settings where environmental conditions and population health can change abruptly. We propose a novel approach to freedom evaluation that is specifically suited to open environments. The approach merges information about pathogen introduction risk with information from pathogen surveillance to estimate assurance of freedom. While the logic is not new, the approach uses a generalizable model designed by an expert panel to estimate introduction probability, easing the need for costly, site‐specific risk assessment. This introduction probability is then used to inform the time‐adjusted value of historical surveillance data and adapt the consequent requirements (sampling volume and frequency) of future surveys. We apply the approach to an open water region on the Pacific Coast of the United States known for its mollusk production. Results support absence of the target pathogens—Marteilia refringens, Marteilioides chungmuensis, Ostreid herpesvirus 1, Perkinsus marinus, and Perkinsus olseni—for the host species, region, and time‐period under investigation. Findings demonstrate (1) the ability to retain assurance in pathogen freedom through time in open systems, (2) the limitations of sample volume, and importance of sampling frequency, for pathogens with higher introduction risk, and (3) expert elicitation as a generalizable alternative to formal risk assessment.
Differences in elemental abundances between CI chondrites and the solar photosphere
Authors: Jurewicz A. J. G. , Amarsi A. M. , Burnett D. S. , Grevesse N. 
Published: October 2024

AbstractCI chondrites have been a proxy for the solar system since the mid‐20th century. The photospheric and CI chondrite abundances (P and CI, respectively) show a strong correlation. CI as a proxy is also justified by the (i) smoothness of their abundances plotted as a function of odd mass number and (ii) agreement within the error of P as determined spectroscopically. But our statistical assessment of spectroscopic studies and solar wind from the Genesis mission indicates that the small, ~10%–30%, differences (residuals) between CI and P depend on the 50% condensation temperature (Tc50). So, if CI is to be used as a proxy for P, Cosmochemists may want to add a correction to individual elements. Our work is consistent with two published hypotheses: that (i) residuals are linear with Tc50 and (ii) that elements having Tc50 > 1343 K are depleted relative to those with 495 K < Tc50 < 1343 K in CI. We discuss other interpretations which are also feasible. Understanding these small differences of the CI and P for different elements and their variation with Tc50 can help constrain future models of solar system formation and the history of CI chondrites.
A New Adaptation of the Authentic Leadership Questionnaire in Turkish: Evidence From Nursing
Authors: Dirik Hasan Fehmi , Seren Intepeler Seyda , Hewison Alistair 
Published: October 2024

ABSTRACTThere is a wide range of leadership approaches, and it is important to measure the types and impact of leadership in nursing. This study aimed to adapt the Authentic Leadership Questionnaire and test its suitability in the Turkish nursing context. Employing a two‐phase cross‐cultural research design in accordance with STROBE guidelines, language adaptation was conducted following ISPOR guidelines. Subsequently, data were collected from a sample of 382 nurses across three hospitals in İzmir, Turkey. The confirmatory factor analysis confirmed the four sub‐scale structures and indices revealed an adequate fit. The content validity index score was 0.97 for the questionnaire and greater than 0.80 for its items, demonstrating excellent validity. The intraclass correlation coefficient obtained was 0.80, indicating a good level of reliability. The findings confirm the questionnaire has the potential to determine the extent and impact of authentic leadership being practiced in hospital settings. It could be used in a range of hospital settings to ensure that accurate evidence concerning authentic leadership is gathered and used to inform the further development of nursing leadership more widely.
Nurses' Experiences With Virtual Consultations and Home‐Monitoring in Patients With Cardiac Disease: A Systematic Review and Qualitative Meta‐Synthesis of Results
Authors: Rosenstrøm Stine , Groth Sissel , Risom Signe Stelling , Hove Jens Dahlgaard , Brødsgaard Anne 
Published: October 2024

ABSTRACTTo explore how nurses experience facilitators and barriers to the use of video‐consultations for home‐monitoring of patients with cardiac disease. A systematic literature search in PubMed, CINAHL, Scopus, and Web of Science was undertaken, inclusion criteria were qualitative data published between 2013 and 2023 written in English, Norwegian, Swedish, or Danish. Ten studies were included in the qualitative synthesis conducted as described by Braun and Clarke. From the synthesis, a main theme emerged: Nurses' uncertainty toward telemedicine is a risk toward the use of video‐consultations and home‐monitoring. The essence of the findings range from nurses' positive experiences to their frustration concerning the implementation process and the lack of technical support for clinicians and patients. Nurses often felt frustration and uncertainty about the quality of delivered care through virtual consultations. Working with technology in caring for patients with cardiac disease, including video‐consultations and home‐monitoring, nurses experienced a sense of insecurity. Insecurity was identified as a lack of technological knowledge, nurses' feelings of apathy, poorer observation through a video‐consultation, and the lack of organizational support.
Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression by Modulating Autophagy
Authors: Yuan Keyong , Xu Shengming , Liu Guanglong , Han Yong , Hu Jingzhou , Zhang Wuchang , Zhang Zhiyuan , Liu Liu , Huang Zhengwei , Zhu Yu , Liu Shuli 
Published: October 2024

ABSTRACTObjectivesPorphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with various gastro‐intestinal tract cancers. However, whether P. gingivalis can promote oral squamous cell carcinoma (OSCC) and the underlying mechanism associated with such promotion remain unclear.Materials and MethodsIn this study, OSCC xenograft models were used to evaluate the effects of P. gingivalis on tumor progression. The functional studies were done on several OSCC cell lines in vitro. P. gingivalis‐specific 16S rRNA fluorescent in situ hybridization (FISH) was used to test its prevalence in clinical samples.ResultsWe found that P. gingivalis increased tumor volume and tumor growth in OSCC nude models. Functional studies demonstrated that P. gingivalis inhibited the apoptosis of OSCC cells by promoting cellular autophagy. P. gingivalis was more prevalent in FISH samples from patients with OSCC than from patients with leukoplakia or healthy subjects (70% vs. 47.2% vs. 33.3%, p = 0.045 and p < 0.001, respectively).ConclusionThese data suggest that P. gingivalis plays an accelerating role in OSCC progression and contributes to OSCC by enhancing the autophagy pathway to reduce carcinoma apoptosis.
Diagnostic Accuracy of Toluidine Blue Electrospun in Detecting Oral Potentially Malignant Disorders
Authors: Supakornpichan Supanat , Tipduangta Pratchaya , Pongsiriwet Surawut , Chamusri Nutchapon , Ittichaicharoen Jitjiroj , Sriyaranya Nutchada 
Published: October 2024

ABSTRACTObjectiveOral potentially malignant disorders (OPMDs) with epithelial dysplasia can progress to oral squamous cell carcinoma (OSCC). Toluidine blue (TB) has been used in oral screening with various methods. This study aimed to evaluate the sensitivity and specificity of TB‐containing electrospun fibers in detecting OPMDs with epithelial dysplasia compared to histopathology.MethodsThe concentrations of polyvinylpyrrolidone (PVP) and TB were optimized for fiber diameter and puncture strength using the design of experiments method with a central composite design. These optimized fibers were tested on 36 suspected OPMD lesions in 30 patients, followed by a biopsy for histopathological examination.ResultsThe quadratic and two‐factor interaction models described the relationship between TB and PVP concentrations and fiber characteristics. The TB‐containing electrospun fibers had 77.3% sensitivity and 35.7% specificity in detecting OPMDs with epithelial dysplasia.ConclusionThe TB‐containing electrospun fibers offer advantages such as easy application, cost‐effectiveness, and enhanced sensitivity in identifying OPMDs with epithelial dysplasia. However, their diagnostic accuracy is insufficient as a standalone diagnostic method, and they should be considered an adjunctive tool for detecting dysplastic changes in the oral epithelium.Trial RegistrationThailand Clinical Trials Registry: TCTR20240429002
Oral Health‐Related Quality of Life in Dutch Adults With Osteogenesis Imperfecta
Authors: de Kuijper‐Timmermans Emmanuelle , Blokland Lieke , de Kuijper Maurits , Kalaykova Stanimira , Zillikens M. Carola , Appelman‐Dijkstra Natasha M. , Gooijer Koert , Harsevoort Arjan , Janus Guus J. M. 
Published: October 2024

ABSTRACTObjectiveTo explore the oral health‐related quality of life and its possible risk factors among adults with Osteogenesis Imperfecta using the Oral Health Impact Profile (OHIP)‐49 questionnaire. Secondary objectives were to investigate the impact of self‐reported Osteogenesis Imperfecta, Dentinogenesis Imperfecta, and age on various dental parameters.Materials and MethodsA cross‐sectional questionnaire was distributed online to 417 Dutch adults with Osteogenesis Imperfecta at three national referral centers. Multivariate linear regression was performed to identify indicators for OHIP‐49 Scores. The effect of Osteogenesis Imperfecta, Dentinogenesis Imperfecta, and age on various dental parameters was investigated using logistic regressions (p < 0.05).ResultsOne hundred and fifty‐five questionnaires (37.2%) were suitable for analysis. Osteogenesis Imperfecta type III was significantly associated with higher OHIP‐49 scores as compared to type I. Symptoms of temporomandibular disorders, missing teeth or dentures also increased the OHIP‐49 scores significantly. Osteogenesis Imperfecta type IV and increasing age were associated with missing teeth. There was a 31.94 times (95% CI: 8.56–119.13) higher odds of tooth fracture with self‐reported Dentinogenesis Imperfecta.ConclusionsAdults with Osteogenesis Imperfecta type III report a lower oral health‐related quality of life compared to Osteogenesis Imperfecta type I adults.
Postoperative Harris Hip Score Versus Harris Hip Score Difference in Hip Replacement: What to Report?
Authors: Ramadanov Nikolai , Voss Maximilian , Hable Robert , Hakam Hassan Tarek , Prill Robert , Salzmann Mikhail , Dimitrov Dobromir , Becker Roland 
Published: October 2024

ABSTRACTBackgroundReliable scientific information is crucial for assessing hip function and evaluating the success of hip surgery. The Harris Hip Score (HHS) is the most widely used tool for measuring hip function and, in particular, the outcomes of hip surgery. The aim of this study was to conduct a systematic review of the literature to identify randomized controlled trials (RCTs) that reported the HHS for hip replacement treatment groups and to test whether there was a substantial difference between reporting only the postoperative HHS or the HHS difference (HHSdiff).MethodsPubMed, CNKI, and Epistemonikos were searched until March 1, 2024. The risk of bias, level of evidence, and publication bias were assessed. As HHS is a continuous outcome, mean difference (MD) with 95% confidence intervals (CIs) was calculated using the Hartung–Knapp–Sidik–Jonkman method and a common‐effect/random‐effects model. The same approach was used for both postoperative HHS and HHSdiff. The effect of the two treatment groups studied (minimally invasive vs. conventional approach) on postoperative HHS was then compared with the effect of the two groups studied on the difference in HHS.ResultsA total of 41 RCTs, involving 3572 patients, with a low to high risk of bias and a low to moderate publication bias were included. The measured outcome parameters showed a low to moderate level of evidence. There was no relevant difference in the reporting of HHS only postoperatively or HHSdiff when comparing two hip replacement treatment groups in RCTs, measured at 0–0.5, 3, 6, and 12 months postoperatively.ConclusionThe present study showed that there is no relevant difference between reporting of the HHS only postoperatively or HHSdiff when comparing two hip replacement treatment groups in RCTs. Both methods of HHS reporting produced comparable results in an identical cohort of 3765 patients undergoing hip replacement surgery.
Optimizing the anesthetic care of patients with aromatic l‐amino acid decarboxylase deficiency
Authors: Kanjia Megha K. , Jooste Edmund H. , Illig Melissa , Neifeld Capps Jennifer , Eisner Christoph , Fan Shou Zen , Lenarczyk Jerzy , Wojdacz Rafał 
Published: October 2024

AbstractAromatic l‐amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive disorder that results in a lack of the monoamine neurotransmitters dopamine, serotonin, norepinephrine, and epinephrine. Patients present with a wide spectrum of symptoms, including motor and autonomic dysfunction, hypotonia, and developmental delay, often before the age of one. Until recently, treatment options were limited to symptom control, but the recent approval of the first gene therapy for AADC deficiency in Europe and the UK has provided an alternative to treating symptoms for this disease. Eladocagene exuparvovec is a one‐time gene therapy, administered bilaterally to the putamen by magnetic resonance imaging‐guided stereotactic neurosurgery. While administration of the gene therapy itself is minimally invasive, the anesthetic management of patients with AADC deficiency is challenging due to the absence of sympathetic regulation secondary to the lack of adrenergic neurotransmitters. Optimal anesthetic management requires an understanding of the complex and heterogeneous nature of the disease. Hemodynamic instability, temperature dysregulation, and hypoglycemia are of primary concern, but there are also challenges regarding intravenous access and airway management. A thorough preoperative assessment is essential and should be guided by the patient's history. Advanced planning is necessary regarding the timing of the procedure schedule and operative plan; meticulous preparation, simulation for the operating room, as well as communication with all perioperative staff members, are crucial. Intraoperatively, utmost care must be taken to protect the skin, maintain body temperature, and to prepare for inotropic and/or glycemic support as needed. Postoperative intensive care management is necessary for consideration of postoperative extubation and provision of supportive care. With careful planning, preparation, and vigilance, patients with AADC deficiency can safely undergo anesthesia.
Longitudinal effects of father‐adolescent attachment on anxiety: A multi‐informant study
Authors: Vetterly Savannah , Dennis Sarah Hoegler , Davies Patrick T. , Cummings E. Mark 
Published: October 2024

AbstractResearch has demonstrated that many elements of the family context can play a significant role in the development of anxiety in adolescents. Some work suggests that parent‐adolescent attachment may serve as an antecedent of adolescent anxiety problems, but there remains a gap in research that examines both the mother‐adolescent and father‐adolescent attachment relationship and its impact on adolescent anxiety. Evidence suggests that parent‐child attachment security may provide a context for the development of emotion regulation skills; if an adolescent lacks these important regulatory capabilities in a time of stressful transitions, this may be related to increased feelings of anxiety. However, little is known about the particular effects of father‐adolescent attachment on anxiety, especially in early to mid‐adolescence. The present study addresses parental influences on the development of adolescent anxiety in a sample of 295 mothers, fathers, and adolescents studied across three years. Two dyadic growth‐curve models were specified: one for mother‐adolescent dyads and the other for father‐adolescent dyads. Results indicated that linear increases in adolescent reports of secure attachment with their fathers were predictive of linear decreases in adolescent reports of anxiety. Interestingly, there were no significant effects for the mother‐adolescent model. The results call attention to the developmental significance of attachment to fathers in buffering adolescents from emerging anxiety in this developmental period. The present study contributes to a growing body of research that highlights the importance of the father‐child relationship in adolescence.
Cow dung compost and vermicompost amendments promote soil carbon stock by enhancing labile organic carbon and residual oxidizable carbon fractions in maize field soil
Authors: Pan Chia‐Chen , Huang Cheng‐Hua 
Published: October 2024

AbstractEnhancing soil quality and promoting the accumulation of soil organic carbon through economically and environmentally sustainable practices are essential for modern agriculture. This study aimed to investigate the effects of various organic amendments and rotation systems on soil properties and sweet corn growth in sandy loam soil. A split‐plot field experiment was conducted over 2 years, including rotations with or without Sesbania sesban as the main plot and six fertilizer treatments: a no fertilizer control, chemical fertilizer and four organic amendments as subplots. The cropping system did not significantly influence soil properties and sweet corn growth. However, the application of soybean meal, castor meal, cow dung compost and vermicompost resulted in sweet corn yields comparable to those achieved with the chemical fertilizer treatment. Notably, the soil organic matter (SOM) content was significantly higher in the cow dung compost and vermicompost treatments compared with both the no fertilizer and chemical fertilizer treatments. Moreover, these two amendments significantly increased soil carbon stock because of significant increases in labile organic carbon (TOC400) and residual oxidizable carbon (ROC) fractions in the maize field soil. A significant positive correlation was observed between fresh ear weight with husks and several soil parameters, including electrical conductivity, available P, exchangeable K and Zn, NO3–N, NH4–N, inorganic C and N, TOC400, ROC and SOM. In conclusion, cow dung compost and vermicompost not only result in sweet corn yields comparable to those from chemical fertilizer but also significantly enhance soil carbon stock by increasing TOC400 and ROC. Therefore, they can partially substitute for chemical fertilizers in promoting sustainable agricultural production of sweet corn.
Identification of the Novel HLA‐DQB1*06:432 Allele by Sequence‐Based Typing
Authors: Yang John Jeongseok , Oh Heung‐Bum 
Published: October 2024

ABSTRACTHLA‐DQB1*06:432 differs from HLA‐DQB1*06:09:01:01 by a nonsynonymous nucleotide substitution in codon 186, changing Valine to Methionine.
Workplace affordances and learning engagement in a Thai paediatric intensive care unit
Authors: Trisukhon Kanaporn , Thammasitboon Satid , Vaewpanich Jarin , Petrescu Matei , Punyoo Jiraporn , Jongaramraung Jongjai , Pakakasama Samart , Balmer Dorene F. 
Published: October 2024

AbstractBackgroundWorkplace learning in critical care settings is complex and challenging. Research has explored learner‐, teacher‐, and context‐related factors that influence medical residents' engagement in critical care workplaces in Western but not in non‐Western cultures. This limits our understanding of workplace learning globally and how we can better support resident learning in diverse cultures.ObjectiveTo explore how paediatric residents engage in workplace learning in a Thai Paediatric Intensive Care Unit (PICU) and how this culturally situated workplace shapes their learning.MethodsIn this qualitative study, we recruited paediatric residents (n = 16) from a tertiary care hospital in Thailand for semi‐structured interviews. We used reflexive thematic analysis to describe, analyse and interpret residents' experiences of workplace learning, and to capitalise on our own experience as an analytic resource.ResultsWe constructed three themes to represent participants' narratives: PICU cases and context as dynamic affordances; impact of psychological safety; and the role of attending physicians. While Thai PICU cases and context could afford participation and thus learning, Thailand's collectivist culture, which prioritises group needs over individual needs, contributed to a sense of psychological safety within culturally‐endorsed, professional and social hierarchies, and set the stage for workplace learning. Despite their higher status in these hierarchies, attending physicians facilitated resident learning by fostering open dialogue, joint problem‐solving and a low‐stress atmosphere.ConclusionsWorkplace learning in a Thai PICU while challenging, is uniquely facilitated by Thailand's collectivist culture that fosters psychological safety and attending physicians' invitation in, and learn from, the workplace optimises learning.