bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing Tb3+‐Sensitized Silica‐Nanoparticles‐Aided Eu3+‐Doped Sr2SiO4 Phosphors with Enhanced Luminescence for Anti‐Counterfeiting Applications
Authors: Mayavan Abinaya , Ganesamurthi Jaysiva , Balaji Ramachandran , Kumar Santosh , Srither Satturappan Ravisekaran 
Published: October 2024

Silica‐nanoparticles‐assisted Eu3+‐doped Sr2SiO4 and Tb3+‐ and Eu3+‐co‐doped Sr2SiO4 phosphors, as potential phosphors for anti‐counterfeiting application are synthesized via a solid‐state reaction technique. The crystal structure, photoluminescence, and decay times are investigated. The characteristic emission of Eu3+‐doped Sr2SiO4 phosphors exhibits two major peaks at 617 and 595 nm under an excitation wavelength of 394 nm, which corresponds to 5D0 → 7F2 and 5D0 → 7F1 electron transitions of Eu3+ ions. Upon co‐doping with Tb3+, the red emission intensities of the Eu3+‐doped Sr2SiO4 phosphors are enhanced by 1.78‐fold times through an energy‐transfer process. The optimized Tb3+‐ and Eu3+‐co‐doped Sr2SiO4 phosphors show a decay time of 0.49 ns and an energy‐transfer efficiency of 73%. The calculated International Commission on Illumination value (x, y) and color purity are (0.63, 0.37) and 94%, respectively. Subsequently, a luminescent ink is formulated using the optimized phosphor and tested for efficiency on currency notes. Additionally, a flexible film is fabricated, and its luminescence properties are studied. The formulated ink can serve as security ink in the anti‐counterfeiting application.
The Sexual Dimorphism in Rectum and Protein Digestion Pathway Influence Sex Pheromone Synthesis in Male Bactrocera Dorsalis
Authors: Chen Jingxiang , Jiang Yanling , Gao Zijie , Dai Jiawang , Jia Chunsheng , Lu Yongyue , Cheng Daifeng 
Published: October 2024

AbstractSexual dimorphism is a crucial aspect of mating and reproduction in many animals, yet the molecular mechanisms remain unclear. In Bactrocera dorsalis, sex pheromones trimethylpyrazine (TMP) and tetramethylpyrazine (TTMP) are specifically synthesized by Bacillus strains in the male rectum. In the female rectum, Bacillus strains are found, but TMP and TTMP are not, indicating sexually dimorphic differences in sex pheromone synthesis. Our anatomical observations and precursor measurements revealed significant differences in rectal structure and ammonium levels between sexes. In vitro and in vivo experiments reveal that ammonium is vital for sex pheromone synthesis in rectal Bacillus strains. Comparative transcriptome analysis identified ammonium‐producing genes (carboxypeptidase B and peptide transporter) in the protein digestion pathway that show much higher expression in the male rectum than in the female rectum. Knocking down the expression of either carboxypeptidase B (or inhibiting enzyme activity) or peptide transporter decreases rectal ammonium levels significantly, resulting in the failure of sex pheromone synthesis in the male rectum. This study provides insights into the presence of sexual dimorphism in internal organs and their functionalities in male‐specific sex pheromone synthesis and has significant implications for understanding the molecular mechanisms underlying sex pheromone synthesis by symbionts in insects.
Geostrategic dimensions of recent food policy decisions
Authors: Wieck Christine , Rudloff Bettina , Mensah Kristina , Kareem Olayinka , Montesclaros Jose Ma Luis , Orden David , Søndergaard Niels , Yu Wusheng 
Published: October 2024

AbstractThis article analyzes the geostrategic dimensions in food policy responses to two recent global shocks: the Corona‐SARS‐CoV‐2 pandemic and the Russian war against Ukraine. The analysis adds to the general assessments of economic security by providing a case study of food policy and food security as an element of economic security. Strong national path dependent trajectories in food policies can be observed. However, geostrategic dimensions related to interstate interaction and political considerations in policymaking that go beyond food security are also observed.
Construction of Z‐type heterojunction Bi4Ti3O12/g‐C3N4 with pyroelectric effect for enhanced photocatalytic performance
Authors: Cheng Ze , Zhu Fuxiao , Jin Bihui , Hou Zhenhua , Li Hongbin , Zhang Gongliang , Hou Hongman , Bi Jingran , Yan Shuang , Hao Hongshun 
Published: October 2024

AbstractPhotocatalytic technology has been widely studied, discussed, and tested as a feasible wastewater degradation technology. The present study demonstrated the preparation of g‐C3N4 material using solid‐state sintering method and the construction of Bi4Ti3O12/g‐C3N4 heterostructure via hydrothermal method. This direct contact Z‐type heterojunction improves the wide bandgap of Bi4Ti3O12 monomer, enhances its photoresponsiveness, and thus improves its photocatalytic performance. During the process of photocatalytic experiments, an environment of cold and hot fluctuations were created, and the pyroelectric effect was utilized to induce self‐polarization of the material and formed an internal electric field. It improves the transport ability of electron–hole pairs and suppresses their recombination in the transport path. According to the degradation experiment results, the degradation efficiency of pyroelectric synergistic heterojunction photocatalysis reached 88.7%, which was 2.27 times that of Bi4Ti3O12. It proves that the photocatalysis by pyroelectric synergistic heterojunction has good application prospects.
Comparative analysis of meningeal transcriptomes in birds: Potential pathways of resilience to repeated impacts
Authors: Beatty Abby E. , Barnes‐Tompkins Tara M. , Long Kira M. , Tobiansky Daniel J. 
Published: October 2024

AbstractThe meninges and associated vasculature (MAV) play a crucial role in maintaining cerebral integrity and homeostasis. Recent advances in transcriptomic analysis have illuminated the significance of the MAV in understanding the complex physiological interactions at the interface between the skull and the brain after exposure to mechanical stress. To investigate how physiological responses may confer resilience against repetitive mechanical stress, we performed the first transcriptomic analysis of avian MAV tissues using the Downy Woodpecker (Dryobates pubescens) and Tufted Titmouse (Baeolophus bicolor) as the comparison species. Our findings reveal divergences in gene expression profiles related to immune response, cellular stress management, and protein translation machinery. The male woodpeckers exhibit a tailored immune modulation strategy that potentially dampens neuroinflammation while preserving protective immunity. Overrepresented genes involved in cellular stress responses suggest enhanced mechanisms for mitigating damage and promoting repair. Additionally, the enrichment of translation‐associated pathways hints at increased capacity for protein turnover and cellular remodeling vital for recovery. Our study not only fills a critical gap in avian neurobiology but also lays the groundwork for research in comparative neuroprotection.
Limiting Behavior of Mixed Coherent Systems With Lévy‐Frailty Marshall–Olkin Failure Times
Authors: Lagos Guido , Barrera Javiera , Romero Pablo , Valencia Juan 
Published: October 2024

ABSTRACTIn this article, we show a limit result for the reliability function of a system—that is, the probability that the whole system is still operational after a certain given time—when the number of components of the system grows to infinity. More specifically, we consider a sequence of mixed coherent systems whose components are homogeneous and non‐repairable, with failure‐times governed by a Lévy‐Frailty Marshall–Olkin (LFMO) distribution—a distribution that allows simultaneous component failures. We show that under integrability conditions the reliability function converges to the probability of a first‐passage time of a Lévy subordinator process. To the best of our knowledge, this is the first result to tackle the asymptotic behavior of the reliability function as the number of components of the system grows. To illustrate our approach, we give an example of a parametric family of reliability functions where the system failure time converges in distribution to an exponential random variable, and give computational experiments testing convergence.
Framework for Cyber Risk Loss Distribution of Client‐Server Networks: A Bond Percolation Model and Industry Specific Case Studies
Authors: Chiaradonna Stefano , Jevtić Petar , Lanchier Nicolas , Pesic Sasa 
Published: October 2024

ABSTRACTCyber risk has emerged as a significant threat to businesses that have increasingly relied on new and existing information technologies (IT). Across various businesses in different industries and sectors, a distinct pattern of IT network architectures, such as the client‐server network architecture, may, in principle, expose those businesses, which share it, to similar cyber risks. That is why in this article, we propose a probabilistic structural framework for loss assessments of cyber risks on the class of client‐server network architectures with different client types. To our knowledge, there exist no theoretical models of an aggregate loss distribution for cyber risk in this setting. With this structural framework via the exact mean and variance of losses, we demonstrate how the changing cybersecurity environment of a business's IT network impacts the loss distribution. Furthermore, our framework provides insights into better investment strategies for cybersecurity protection on the client‐server network. Motivated by cyberattacks across industries, we apply our framework to four case studies that utilize the client‐server network architecture. Our first application is implantable medical devices in healthcare. Our second application is the smart buildings domain. Third, we present an application for ride‐sharing services such as Uber and Lyft. The fourth is the application of vehicle‐to‐vehicle cooperation in traffic management. The results are corresponding exact means and variances of cyber risk loss distributions parameterized by various cybersecurity parameters allowing for liability assessments and decisions in cybersecurity protection investments.
Characteristic Changes of Prefrontal and Motor Areas in Patients with Type 2 Diabetes and Major Depressive Disorder During a Motor Task of Tai Chi Chuan: A Functional Near‐Infrared Spectroscopy Study
Authors: Zhang Jiaming , Li Yuxi , Liu Xiaobo , Zhong Dongling , Xue Chen , Fan Jin , Xie Cheng , Li Juan , Jin Rongjiang 
Published: October 2024

ABSTRACTAimThis cross‐sectional study aims to identify the characteristic changes of prefrontal and motor areas during a tai chi chuan task in patients with Type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD) using wearable functional near‐infrared spectroscopy (fNIRS).MethodsThree parallel groups (T2DM with DD group, T2DM group, and healthy group) were recruited from December 10, 2022, to May 31, 2023. Participants in three groups conducted a motor task of tai chi chuan designed by Eprime 3.0, and fNIRS was used to monitor the brain activation, functional connectivity (FC), and lateralization of prefrontal and motor areas. Correlation analyses were performed to examine the relationship between depressive symptoms and the function of prefrontal and motor areas.ResultsNinety elder adults (aged ≥ 60), including 30 patients with T2DM and MDD, 30 patients with T2DM, and 30 healthy subjects, were enrolled. In contrast with the patients with T2DM and healthy subjects, the patients with T2DM and MDD had decreased activation and abnormal lateralization in prefrontal and motor areas and decreased FC among supplementary motor area, motor area, and dorsolateral prefrontal cortex (DLPFC). Furthermore, the oxyhemoglobin (HbO2) concentration value of DLPFC in patients with T2DM and MDD was negatively associated with scores of Hamilton Depression Scale‐24 (HAMD‐24).ConclusionsPatients with T2DM and MDD had characteristic functional changes in prefrontal and motor areas. DLPFC may be a potential target of diagnosis and intervention for patients with T2DM and MDD.
An Empirical Study on the Effect of Blended Scents in Driving Environments From a Neuro‐Cognitive Perspective
Authors: Li Tan , Sun Hua , Wang Mianjie , Dai Weihui , Qian Xuesheng 
Published: October 2024

ABSTRACTBackgroundAn effective method that is easy to implement and widely applicable for improving driving performance and reducing driving risks remains a challenge. Although fragrances are widely used in daily driving, there is a gap between empirical research on everyday blended fragrances and functional fragrances clinical reports. In this study, a deliberately chosen blend of scent without overtly stimulating or functional proven evidence was tested for its potential to enhance performance in a driving environment.MethodThirty qualified young drivers were recruited to participate in the experiment. They were asked to watch a 15‐min first‐person perspective driving video to simulate a driving environment and then complete questionnaires and three sets of behavioral experiments while their brain activity was monitored by EEG.ResultParticipants in the scented environment exhibited statistically significant advantages in two cognitive tasks during behavioral measures. These findings were effectively supported by the EEG data, showing that beta waves exhibited more activity in the occipital and prefrontal cortex, enhanced theta waves were observed in the prefrontal cortex, and the TAB index characterizing driving fatigue was suppressed in the prefrontal cortex.ConclusionThis empirical evidence highlights the potential of pleasant, natural, and blended scents in enhancing driving performance, suggesting that promoting the aromatherapy while driving as an easily applicable approach in daily life seems justified and expands the application of aromatherapy in daily life.
Quantitative Electroencephalography Monitoring in Type A Aortic Dissection Surgery: A Clinical Case Review and Prospective Applications
Authors: Wang Ya‐Peng , Qu Jason Z. , Wang Dong‐Jin 
Published: October 2024

ABSTRACTPurposeThis review explores advanced methods for assessing perioperative cerebral function in Type A aortic dissection (TAAD) patients, with a focus on quantitative electroencephalography (QEEG). It highlights the critical issue of cerebral malperfusion, which is associated with higher mortality and poor prognosis during the perioperative phase in TAAD patients.MethodThe review centers on the utilization of QEEG as a pivotal tool for the extensive monitoring of brain function at various stages: preoperatively, intraoperatively, and postoperatively. It elaborates on the foundational principles of QEEG, including the mathematical and computational analysis of electroencephalographic signals, enriched with intuitive graphical representations of cerebral functional states.FindingQEEG is presented as an innovative approach for the real‐time, noninvasive, and reliable assessment of cerebral function. The review details the application of QEEG in monitoring conditions such as preoperative cerebral malperfusion, intraoperative deep hypothermic circulatory arrest, and postoperative recovery of cerebral function in patients undergoing TAAD treatment.ConclusionAlthough QEEG is still in an exploratory phase for TAAD patients, it has shown efficacy in other domains, suggesting its potential in multimodal brain function monitoring. However, its broader application requires further research and technological advancements.
Development of a virtual teaching module for advanced semiconductor fabrication and its learning effectiveness analysis
Authors: Tarng Wernhuar , Huang Jen‐Kai , Shu Jen‐Chu , Lin Yu‐Hsuan , Chang Ting‐Yun , Jwo Hsin‐Yu , Tang Chun‐Wei 
Published: October 2024

AbstractSemiconductor fabrication is the process of manufacturing semiconductor devices, typically integrated circuits (ICs) such as microprocessors and memory. This involves transferring circuit diagrams onto a silicon wafer using photomasks and photoresists. After a series of fabrication processes, ICs are created on the wafer surface and then diced into individual chips, which are packaged and tested with quality control procedures to become the final products. Virtual reality (VR) simulates imaginary experiences or environments difficult to achieve in the real world through human senses and immersive equipment, allowing users to interact in a virtual 3D space in real time, making it well suited for applications in science education and industrial training. This study transforms the essential knowledge of advanced semiconductor manufacturing processes into an easily understandable virtual teaching module, thereby creating educational resources for high school and college students. The objective is to enhance their scientific and technological literacy, yielding substantial benefits for the general public. This study utilized VR technology to simplify and clarify the knowledge about the semiconductor manufacturing process, making it more engaging for learners. The virtual teaching module's learning content includes an overview of wafer preparation, semiconductor fabrication, chip packaging, and IC testing. Users can interact with the virtual teaching module and conduct virtual experiments to enhance their understanding by trial and error. Experimental results show that it can improve students' learning achievement and learning motivation. Therefore, the virtual teaching module is suitable for high‐school students and the general public to understand semiconductor technology and its applications. The effectiveness of the virtual teaching module is heavily dependent on the availability and quality of VR hardware and software. Limited access to advanced VR equipment or technical issues could have affected the learning experience, thereby influencing the learning outcomes.
Alpelisib and Immunotherapy: A Promising Combination for Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck
Authors: Suleiman Riham , McGarrah Patrick , Baral Binav , Owen Dawn , Vera Aguilera Jesus , Halfdanarson Thor R. , Price Katharine A. , Fuentes Bayne Harry E. 
Published: October 2024

ABSTRACTBackgroundRecurrent squamous cell carcinoma (SCC) of the head and neck (SCCHN) remains a formidable clinical challenge despite available treatments. The phosphatidylinositol 3‐kinase (PI3K) pathway has been identified as a potential therapeutic target, and alpelisib, a selective PI3Kα inhibitor, has demonstrated efficacy in certain malignancies. Combining this targeted therapy with immunotherapy has been suggested in previous studies as a promising strategy to bolster the immune response against cancer.CasesA 69‐year‐old woman with locoregional recurrence of PIK3CA‐mutated SCC of the left maxilla and cervical nodal metastases. Several chemotherapeutic regimens, including cisplatin, docetaxel, 5FU, chemoradiotherapy, and mono‐immunotherapy, resulted in disease progression. Alpelisib combined with pembrolizumab led to a sustained response for 9 months. A 58‐year‐old man with recurrent metastatic PIK3CA‐mutated SCC of the oropharynx, involving the left lung, hilar, and mediastinal lymph nodes. Despite prior palliative radiation and platinum‐based chemotherapy with pembrolizumab and cetuximab, treatment with alpelisib and nivolumab resulted in a partial response. Severe hyperglycemia and rash led to treatment discontinuation.ConclusionOur findings highlight the potential of this innovative therapeutic combination, suggesting a need for further investigations in this setting.
Improving Health Outcomes Through Treatment Sequencing Optimization in Multiple Myeloma: A Simulation Model in Transplant‐Ineligible Patients
Authors: Geraldes C. , Neves M. , Bergantim R. , Silva C. , Leal da Costa F. 
Published: October 2024

ABSTRACTObjectivesPatients with multiple myeloma often require multiple treatment lines. The order in which treatments are sequenced has impact on clinical outcomes. This study aimed to estimate progression‐free survival (PFS) and overall survival (OS) with common treatment sequences used in Portugal and the incremental benefit of an optimal sequence in transplant‐ineligible patients with multiple myeloma.MethodsA state‐transition sequential model with a five‐health state conceptual structure was developed to simulate and compare survival outcomes between treatment sequences up to four lines of treatments. Data sources included randomized clinical trials and indirect treatment comparisons. A panel of Portuguese hematologists listed four most common treatment sequences and optimal sequence of choice in transplant‐ineligible patients.ResultsOur simulation estimated an OS between 6.1 and 7.8 years using the most common sequences, with VMP + DRd + Pd + Kd as the most effective (7.8 years). Optimal sequence of choice (DRd + PVd + Kd + Vd) achieved OS of 9.8 years and may extend OS in 2.0–3.7 years vs. most common sequences (26%–61% increase). This benefit was mostly explained by extended PFS in the first line of treatment.ConclusionModel results demonstrate that choosing the most effective treatment upfront is crucial in delaying disease progression thus yielding better survival outcomes in transplant‐ineligible patients. There was a clear survival benefit in using daratumumab‐based regimens in first line. This modelling exercise highlights the need to raise awareness around the impact of sequencing strategies to improve patient's outcomes.
Multiple‐Input and Multiple‐Output–Based Cascaded Boost Hybrid Interlink Converter
Authors: Islam Shirazul , Iqbal Atif , Hashemzadeh Seyed Majid , Samiullah Md , Abbas Ahmed , Khan Arif , Meraj Mohammad , Bakhsh Farhad Ilahi , Marzband Mousa , Khan Irfan A. 
Published: October 2024

ABSTRACTThe multiple‐input and multiple‐output (MIMO) DC–DC converters offer various advantages such as improved efficiency and reduced component count. However, the preference of these converters over other types of converters is dependent on the specific application and requirements. Various types of boost‐derived MIMO DC–DC converters are discussed in the literature. However, these converters are either nonisolated or isolated types. In the paper, a MIMO‐based cascaded boost hybrid interlink converter (CBHIC) has been proposed. The proposed converter includes four DC–DC boost converters that are supplied power by two input DC sources. The boosted DC output of these converters can be used independently or in a cascaded manner depending upon the requirement of the load. Further, the cascaded action of these four boost converters leads to the production of two high‐frequency AC outputs. By using bridge rectifiers and high‐frequency transformers, high‐frequency AC voltages are converted into DC. Therefore, two isolated DC output voltages can be achieved using CBHIC. The complementary operation of the cascaded boost converters results in reduction of source current ripples. The design, operating modes, and performance evaluation of the proposed CBHIC have been included in the paper. To validate the efficacy of the proposed CBHIC, a lab prototype of 400 W is prepared. The rms value of high‐frequency AC output voltage at each is isolated port is 141 V. The CBHIC exhibits an efficiency of 94.3 at 400 W. The operation of the converter during voltage control mode is further explored and its dynamic response is studies with the help of experimental results. The obtained simulation and experimental results validate the effectiveness of the proposed converter.