bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Health Care Utilization, End‐Stage Renal Disease, and Mortality Among Medicaid Beneficiaries With Incident Lupus Nephritis
Authors: Feldman Candace H. , Broder Anna , Guan Hongshu , Yazdany Jinoos , Costenbader Karen H. 
Published: November 2017

ObjectiveWhile systemic lupus erythematosus and lupus nephritis (LN) disproportionately affect females, previous studies suggest that males may experience poorer outcomes. We undertook this study to investigate sex differences in health care utilization, end‐stage renal disease (ESRD), and mortality among patients with LN receiving Medicaid, public insurance for low‐income individuals.MethodsWithin the Medicaid Analytic eXtract (MAX) from 29 states (from 2000 to 2010), we used billing claims to identify individuals ages 5–65 years with incident LN (positive predictive value 80%). MAX data were linked to the US Renal Data System to determine ESRD and to Social Security Death Index files to determine death. We estimated adjusted incidence rate ratios (IRRs) by sex for health care utilization using Poisson regression, and we used multivariable proportional hazards models to compare risks of ESRD and death by sex.ResultsOf 2,750 patients with incident LN, 283 (10%) were male. The mean ± SD follow‐up period for both sexes was 3.1 ± 2.3 years. The mean ± SD age was 29.6 ± 13.9 years among females and 24.7 ± 14.1 years among males (P < 0.01). Males had fewer outpatient visits (IRR 0.88 [95% confidence interval (95% CI) 0.80–0.97]) and fewer emergency department visits (IRR 0.75 [95% CI 0.63–0.90]). The 5‐year cumulative incidence of ESRD was 22.3% in males and 21.2% in females. The 5‐year cumulative incidence of death was 9.4% in males and 9.8% in females. Comparing males to females, there were no sex differences in ESRD (subdistribution hazard ratio [HR] 1.05 [95% CI 0.76–1.45]) or death (HR 0.81 [95% CI 0.47–1.35]).ConclusionIn this cohort of patients with incident LN, ESRD and mortality were extremely high overall but were not increased among males compared to females. In this vulnerable population, biologic and health care utilization differences by sex may not significantly affect outcomes.
Opportunities and risks for sustainable biomass export from the south‐eastern United States to Europe
Authors: Fingerman Kevin R , Nabuurs Gert‐Jan , Iriarte Leire , Fritsche Uwe R , Staritsky Igor , Visser Lotte , Mai‐Moulin Thuy , Junginger Martin 
Published: November 2017

AbstractImport of wood pellets to the EU from the southeastern United States has increased almost ten‐fold over the past seven years, driven largely by mandates under the Renewable Energy Directive. While the displacement of fossil fuels with biomass can offer significant energy diversity and climate benefits, these must be balanced against the potential detriment from unsustainable extraction of biomass resources. This study projects the scale of the sustainable biomass resource base in the US southeast through 2030 under various scenarios of industry development and domestic market dynamics. We characterise this resource base at the county level, disaggregating it by material type and spatially constraining it to ensure biodiversity conservation. Our analysis shows that there could be as much as 70 million green metric tons of sustainable export potential from the US Southeast in 2030. However, we also show the extent to which sustainable sourcing criteria applied only to EU biomass energy imports could create leakage across biomass markets, erasing gains from any sustainability mandate. This leakage risk was fairly consistent across our study scenarios and time periods, ranging from 50 to over 63 million green tons of biomass per year. Meaningful biodiversity protections can only be achieved if sustainability criteria for biomass import to the EU are combined with more comprehensive support for sustainable sourcing across biomass industries in exporting regions. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd
In utero ultrasound diagnosis of corpus callosum agenesis leading to the identification of orofaciodigital type 1 syndrome in female fetuses
Authors: Alby Caroline , Boutaud Lucile , Bonnière Maryse , Collardeau‐Frachon Sophie , Guibaud Laurent , Lopez Estelle , Bruel Ange‐Line , Aral Bernard , Sonigo Pascale , Roth Philippe , Vibert‐Guigue Claude , Castaigne Vanina , Carbonne Bruno , Joyé Nicole , Faivre Laurence , Cordier Marie‐Pierre , Bernabe Gelot Antoinette , Clementi Maurizio , Mammi Isabella , Vekemans Michel , Razavi Féréchté , Gonzales Marie , Thauvin‐Robinet Christel , Attié‐Bitach Tania 
Published: November 2017

BackgroundOFD1 syndrome is a rare ciliopathy inherited on a dominant X‐linked mode, typically lethal in males in the first or second trimester of pregnancy. It is characterized by oral cavity and digital anomalies possibly associated with cerebral and renal signs. Its prevalence is between 1/250,000 and 1/50,000 births. It is due to heterozygous mutations of OFD1 and mutations are often de novo (75%). Familial forms show highly variable phenotypic expression. OFD1 encodes a protein involved in centriole growth, distal appendix formation, and ciliogenesis.CasesWe report the investigation of three female fetuses in which corpus callosum agenesis was detected by ultrasound during the second trimester of pregnancy. In all three fetuses, fetopathological examination allowed the diagnosis of OFD1 syndrome, which was confirmed by molecular analysis.ConclusionsTo our knowledge, these are the first case reports of antenatal diagnosis of OFD1 syndrome in the absence of familial history, revealed following detection of agenesis of the corpus callosum. They highlight the impact of fetal examination following termination of pregnancy for brain malformations. They also highlight the contribution of ciliary genes to corpus callosum development.
Dihydromyricetin inhibits NLRP3 inflammasome‐dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells
Authors: Hu Qin , Zhang Ting , Yi Long , Zhou Xi , Mi Mantian 
Published: November 2017

AbstractIncreasing evidence demonstrates that pyroptosis, pro‐inflammatory programmed cell death, is linked to atherosclerosis; however, the underlying mechanisms remain to be elucidated. Dihydromyricetin (DHM), a natural flavonoid, was reported to exert anti‐oxidative and anti‐inflammatory bioactivities. However, the effect of DHM on atherosclerosis‐related pyroptosis has not been studied. In the present study, palmitic acid (PA) treatment led to pyroptosis in human umbilical vein endothelial cells (HUVECs), as evidenced by caspase‐1 activation, LDH release, and propidium iodide‐positive staining; enhanced the maturation and release of proinflammatory cytokine IL‐1β and activation of the NLRP3 inflammasome; and markedly increased intracellular reactive oxygen species (ROS) and mitochondrial ROS (mtROS) levels. Moreover, NLRP3 siRNA transfection or treatment with inhibitors efficiently suppressed PA‐induced pyroptosis, and pretreatment with total ROS scavenger or mtROS scavenger attenuated PA‐induced NLRP3 inflammasome activation and subsequent pyroptosis. However, DHM pretreatment inhibited PA‐induced pyroptotic cell death by increasing cell viability, decreasing LDH and IL‐1β release, improving cell membrane integrity, and abolishing caspase‐1 cleavage and subsequent IL‐1β maturation. We also found that DHM pre‐treatment remarkably reduced the levels of intracellular ROS and mtROS and activated the Nrf2 signaling pathway. Moreover, knockdown of Nrf2 by siRNA abrogated the inhibitory effects of DHM on ROS generation and subsequent PA‐induced pyroptosis. Together, these results indicate that the Nrf2 signaling pathway plays a role, as least in part, in the DHM‐mediated improvement in PA‐induced pyroptosis in vascular endothelial cells, which implies the underlying medicinal value of DHM targeting immune/inflammatory‐related diseases, such as atherosclerosis. © 2017 BioFactors, 44(2):123–136, 2018
Early versus late recurrence of intrahepatic cholangiocarcinoma after resection with curative intent
Authors: Zhang X -F , Beal E W , Bagante F , Chakedis J , Weiss M , Popescu I , Marques H P , Aldrighetti L , Maithel S K , Pulitano C , Bauer T W , Shen F , Poultsides G A , Soubrane O , Martel G , Koerkamp B G , Itaru E , Pawlik T M 
Published: November 2017

Abstract

Background
The objective of this study was to investigate the characteristics, treatment and prognosis of early versus late recurrence of intrahepatic cholangiocarcinoma (ICC) after hepatic resection.

Methods
Patients who underwent resection with curative intent for ICC were identified from a multi-institutional database. Data on clinicopathological characteristics, initial operative details, timing and sites of recurrence, recurrence management and long-term outcomes were analysed.

Results
A total of 933 patients were included. With a median follow-up of 22 months, 685 patients (73·4 per cent) experienced recurrence of ICC; 406 of these (59·3 per cent) developed only intrahepatic disease recurrence. The optimal cutoff value to differentiate early (540 patients, 78·8 per cent) versus late (145, 21·2 per cent) recurrence was defined as 24 months. Patients with early recurrence had extrahepatic disease more often (44·1 per cent versus 28·3 per cent in those with late recurrence; P &lt; 0·001), whereas late recurrence was more often only intrahepatic (71·7 per cent versus 55·9 per cent for early recurrence; P &lt; 0·001). From time of recurrence, overall survival was worse among patients who had early versus late recurrence (median 10 versus 18 months respectively; P = 0·029). In multivariable analysis, tumour characteristics including tumour size, number of lesions and satellite lesions were associated with an increased risk of early intrahepatic recurrence. In contrast, only the presence of liver cirrhosis was independently associated with an increased likelihood of late intrahepatic recurrence (hazard ratio 1·99, 95 per cent c.i. 1·11 to 3·56; P = 0·019).

Conclusion
Early and late recurrence after curative resection for ICC are associated with different risk factors and prognosis. Data on the timing of recurrence may inform decisions about the degree of postoperative surveillance, as well as help counsel patients with regard to their risk of recurrence.
Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery
Authors: Carpinteri S , Sampurno S , Malaterre J , Millen R , Dean M , Kong J , Chittleborough T , Heriot A , Lynch A C , Ramsay R G 
Published: November 2017

Abstract

Background
The aim of this study was to monitor the effect of humidified-warm carbon dioxide (HWCO2) delivered into the open abdomen of mice, simulating laparotomy.

Methods
Mice were anaesthetized, ventilated and subjected to an abdominal incision followed by wound retraction. In the experimental group, a diffuser device was used to deliver HWCO2; the control group was exposed to passive air flow. In each group of mice, surgical damage was produced on one side of the peritoneal wall. Vital signs and core temperature were monitored throughout the 1-h procedure. The peritoneum was closed and mice were allowed to recover for 24 h or 10 days. Tumour cells were delivered into half of the mice in each cohort. Tissue was then examined using scanning electron microscopy and immunohistochemistry.

Results
Passive air flow generated ultrastructural damage including mesothelial cell bulging/retraction and loss of microvilli, as assessed at 24 h. Evidence of surgical damage was still measurable on day 10. HWCO2 maintained normothermia, whereas open surgery alone led to hypothermia. The degree of tissue damage was significantly reduced by HWCO2 compared with that in controls. Peritoneal expression of hypoxia inducible factor 1α and vascular endothelial growth factor A was lowered by HWCO2. These effects were also evident at the surgical damage sites, where protection from tissue trauma extended to 10 days. HWCO2 did not reduce tumorigenesis in surgically damaged sites compared with passive air flow.

Conclusion
HWCO2 diffusion into the abdomen in the context of open surgery afforded tissue protection and accelerated tissue repair in mice, while preserving normothermia. Surgical relevanceDamage to the peritoneum always occurs during open abdominal surgery, by exposure to desiccating air and by mechanical trauma/damage owing to the surgical intervention. Previous experimental studies showed that humidified-warm carbon dioxide (HWCO2) reduced peritoneal damage during laparoscopic insufflation. Additionally, this intervention decreased experimental peritoneal carcinomatosis compared with the use of conventional dry-cold carbon dioxide.In the present experimental study, the simple delivery of HWCO2 into the open abdomen reduced the amount of cellular damage and inflammation, and accelerated tissue repair. Sites of surgical intervention serve as ideal locations for cancer cell adhesion and subsequent tumour formation, but this was not changed measurably by the delivery of HWCO2.
Moral processing deficit in behavioral variant frontotemporal dementia is associated with facial emotion recognition and brain changes in default mode and salience network areas
Authors: Van den Stock Jan , Stam Daphne , De Winter François‐Laurent , Mantini Dante , Szmrecsanyi Benedikt , Van Laere Koen , Vandenberghe Rik , Vandenbulcke Mathieu 
Published: November 2017

AbstractIntroductionBehavioral variant frontotemporal dementia (bvFTD) is associated with abnormal emotion recognition and moral processing.MethodsWe assessed emotion detection, discrimination, matching, selection, and categorization as well as judgments of nonmoral, moral impersonal, moral personal low‐ and high‐conflict scenarios.ResultsbvFTD patients gave more utilitarian responses on low‐conflict personal moral dilemmas. There was a significant correlation between a facial emotion processing measure derived through principal component analysis and utilitarian responses on low‐conflict personal scenarios in the bvFTD group (controlling for MMSE‐score and syntactic abilities). Voxel‐based morphometric multiple regression analysis in the bvFTD group revealed a significant association between the proportion of utilitarian responses on personal low‐conflict dilemmas and gray matter volume in ventromedial prefrontal areas (pheight < .0001). In addition, there was a correlation between utilitarian responses on low‐conflict personal scenarios in the bvFTD group and resting‐state fractional Amplitude of Low Frequency Fluctuations (fALFF) in the anterior insula (pheight < .005).ConclusionsThe results underscore the importance of emotions in moral cognition and suggest a common basis for deficits in both abilities, possibly related to reduced experience of emotional sensations. At the neural level abnormal moral cognition in bvFTD is related to structural integrity of the medial prefrontal cortex and functional characteristics of the anterior insula. The present findings provide a common basis for emotion recognition and moral reasoning and link them with areas in the default mode and salience network.
The auditory comprehension changes over time after sport‐related concussion can indicate multisensory processing dysfunctions
Authors: Białuńska Anita , Salvatore Anthony P. 
Published: November 2017

AbstractBackgroundAlthough science findings and treatment approaches of a concussion have changed in recent years, there continue to be challenges in understanding the nature of the post‐concussion behavior. There is growing a body of evidence that some deficits can be related to an impaired auditory processing.PurposeTo assess auditory comprehension changes over time following sport‐related concussion (SRC) in young athletes.MethodsA prospective, repeated measures mixed‐design was used. A sample of concussed athletes (n = 137) and the control group consisted of age‐matched, non‐concussed athletes (n = 143) were administered Subtest VIII of the Computerized‐Revised Token Test (C‐RTT). The 88 concussed athletes selected for final analysis (neither previous history of brain injury, neurological, psychiatric problems, nor auditory deficits) were evaluated after injury during three sessions (PC1, PC2, and PC3); controls were tested once. Between‐ and within‐group comparisons using RMANOVA were performed on the C‐RTT Efficiency Score (ES).ResultsES of the SRC athletes group improved over consecutive testing sessions (F = 14.7, p < .001), while post‐hoc analysis showed that PC1 results differed from PC2 and PC3 (ts ≥ 4.0, ps < .001), but PC2 and PC3 C‐RTT ES did not change statistically (t = 0.6, p = .557). The SRC athletes demonstrated lower ES for all test session when compared to the control group (ts > 2.0, Ps<.01).ConclusionDysfunctional auditory comprehension performance following a concussion improved over time, but after the second testing session improved performance slowed, especially in terms of its timing. Yet, not only auditory processing but also sensorimotor integration and/or motor execution can be compromised after a concussion.
Pretreatment C‐reactive protein/albumin ratio is associated with poor survival in patients with stage IB‐IIA cervical cancer
Authors: Zhang Weiwei , Liu Kejun , Ye Bin , Liang Weijiang , Ren Yazhou 
Published: November 2017

AbstractPrevious studies have shown that the C‐reactive protein/albumin ratio (CAR) is a prognostic indicator in multiple types of carcinomas. This study is the first to evaluate the prognostic significance of CAR in stage IB‐IIA cervical cancer patients treated with radical surgery, as well as that of several other inflammation‐based factors, including the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and prognostic nutritional index (PNI). A total of 235 patients were enrolled in this study. The optimal cut‐off values of CAR and other inflammation‐based factors were determined by receiver operating characteristic curves. The Kaplan–Meier method and Cox regression model analysis were performed to determine the independent predictors of progression‐free survival (PFS) and overall survival (OS). At a cut‐off value of 0.15, patients with a high CAR had significantly shorter PFS and OS than those with a lower CAR (P < 0.001). A higher CAR was significantly associated with elevated scores of NLR and PLR and a decreased PNI (P < 0.001). Univariate analyses showed that elevated CAR preoperatively was significantly associated with poor survival; a similar trend was also noted for the NLR, PLR, and PNI. Multivariate analyses demonstrated that only CAR was an independent indicator for PFS (hazard ratio [HR]: 5.164; 95% confidence interval [CI]: 2.495–10.687; P < 0.001) and OS (HR: 4.729; 95% CI: 2.263–9.882; P < 0.001). In conclusion, preoperative CAR is a novel and superior predictor of poor survival in patients with stage IB‐IIA cervical cancer.
Percutaneous transcatheter pulmonary valve replacement in children weighing less than 20 kg
Authors: Martin Mary Hunt , Shahanavaz Shabana , Peng Lynn F. , Asnes Jeremy D. , Riley Michelle , Hellenbrand William E. , Balzer David T. , Gray Robert G. , McElhinney Doff B. 
Published: November 2017

AbstractBackgroundSince FDA approval of the Melody valve, transcatheter pulmonary valve replacement (TPVR) has been offered to an expanding population. Limited data exist regarding the safety and feasibility of TPVR in smaller patients.MethodsAll patients weighing <20 kg who underwent catheterization for percutaneous TPVR at four centers were reviewed.ResultsOf the 51 patients reviewed, 43 (84%) had successful valve implantation and 8 (16%) were found not to be candidates due to access veins too small (n = 3), coronary artery/aortic root compression (n = 3), and RVOT too large (n = 2). The 43 patients who underwent successful percutaneous TPVR had a median age and weight of 5.8 years (3.3–10) and 17.7 kg (13.5–19.8), and most had tetralogy of Fallot (TOF). TPVR was performed via femoral vein (FV) access in 24 patients and internal jugular vein (IJV) access in 19 patients. Median weight in patients with IJV implant was 1.1 kg lower than those who underwent transfemoral implant (17.0 vs. 18.1 kg, P = 0.05). There were four adverse events: one iliac vein injury, one contained MPA tear, and two patients with post‐procedure femoral vein bleeding. All patients were alive at recent follow‐up, a median of 2.0 years (0.1–6.0) after TPVR. There was excellent valve function with mean Doppler gradients of 3–20 mm Hg, and trivial or mild pulmonary regurgitation in all but one patient. There were no RVOT reinterventions and no cases of endocarditis.ConclusionsPercutaneous TPVR can be safely performed in patients <20 kg. The procedure frequently requires IJV access, and access site/bleeding complications may be more common in this cohort.
Visceral leishmaniasis in a patient with diabetes mellitus type 2 and discrete bicytopenia
Authors: Schwetz Verena , Trummer Christian , Friedl Claudia , Beham‐Schmid Christine , Kulnik Roman , Wölfler Albert , Horvath Karl , Wunsch Stefanie , Prattes Jürgen , Zollner‐Schwetz Ines , Pieber Thomas R. , Mader Julia K. , Krause Robert 
Published: November 2017

Key Clinical MessageAn Austrian patient with diabetes mellitus type 2 developed visceral leishmaniasis after trips to Spain and Crete, presenting with slight bicytopenia, later developing severe pancytopenia. Travel history taking is important due to an extended incubation period. Coexistence of diabetes mellitus can impair T lymphocyte function and cause higher relapse rates.
Cutaneous diffuse large B‐cell lymphoma
Authors: Duarte Ribeiro Filipa , Coelho Henrique , Tente David , Badior Margarida 
Published: November 2017

Key Clinical MessageCutaneous diffuse large B‐cell lymphoma accounts for ~6% of all cutaneous lymphomas. It is associated with poor prognosis, and solitary lesions are relatively rare. It often requires an aggressive approach with multi‐agent chemotherapy and radiotherapy. It is important to recognize these cases in order to offer rapid and appropriate management.
Inflammatory myofibroblastic tumor of the esophagus presenting with hematemesis and melaena: a case report and review of literature
Authors: Jayarajah Umesh , Bulathsinghala Rasika P. , Handagala Dassanayake M Sumana , Samarasekera Dharmabandhu Nandadeva 
Published: November 2017

Key Clinical MessageEsophageal inflammatory myofibroblastic tumors (IMT) are extremely rare, and the understanding on the clinical presentation is limited. IMT of esophagus should be considered as a differential diagnosis in the context of unexplained upper gastrointestinal bleeding and rapidly progressing dysphagia in young patients.
Unexpected discovery of multiple myeloma following cardiomyopathy
Authors: Dahraoui Souhail , Uwingabiye Jean , Belarj Badia , Biaz Asmae , Rachid Achraf , Dami Abdellah , Bouhsain Sanae , Ouzzif Zohra , Elmachatni Idrissi Samira 
Published: November 2017

Key Clinical MessageWe report the case of multiple myeloma of unexpected discovery in an old patient admitted to the emergency department of cardiomyopathy. This observation emphasizes the need for exploring any anemia before linking it to heart failure or kidney disease. Serum protein electrophoresis remains crucial especially in the elderly patients.
Mosaic upd(14)pat in a patient with mild features of Kagami–Ogata syndrome
Authors: Haug Marte G. , Brendehaug Atle , Houge Gunnar , Kagami Masayo , Ogata Tsutomu 
Published: November 2017

Key Clinical MessageWe report a Norwegian girl with mild clinical features of Kagami–Ogata syndrome (KOS) and mosaic upd(14)pat. To our knowledge, this is the first report describing a mosaic patient with KOS. These results imply that mosaic uniparental disomy should be examined in patients with mild features of imprinted disorders.