bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confirming the mechanisms behind cognitive‐behavioural therapy effectiveness in chronic pain using structural equation modeling in a sample of patients with temporomandibular disorders
Authors: Durá‐Ferrandis Estrella , Ferrando‐García Maite , Galdón‐Garrido Mª José , Andreu‐Vaillo Yolanda 
Published: August 2017

ObjectiveTo evaluate whether therapeutic mechanisms assumed to explain the effect of cognitive behavioural therapy (CBT) concerning temporomandibular symptoms are confirmed by structural equation modelling.MethodPatients were randomly assigned to either an experimental group receiving CBT (N = 41) or a standard therapy control group (N = 31). Subjects were assessed before and after intervention using mediator variables hypothesized according to the CBT model, as well as outcome variables and other socio‐demographic and clinical measures.ResultsThe results confirm that the effect of treatment on pain intensity was partially mediated by distress, catastrophizing, perceived control, distraction, and mental self‐control. The self‐medication frequency was partially mediated by distraction. Pain interference was partially mediated by distress, distraction, and mental self‐control. Reduction in the number of painful points on palpation was partially explained by distress, although in this case, there was a significant direct effect of treatment not mediated by other variables.ConclusionsThe results could set the principles for the development of more efficient and effective cognitive behavioural interventions for chronic pain.
The association between dysregulated adipocytokines in early pregnancy and development of gestational diabetes
Authors: Abell Sally K. , Shorakae Soulmaz , Harrison Cheryce L. , Hiam Danielle , Moreno‐Asso Alba , Stepto Nigel K. , De Courten Barbora , Teede Helena J. 
Published: August 2017

AbstractBackgroundTo investigate the association of adipocytokines and other inflammatory markers with development of GDM.MethodsSerum adipocytokines and inflammatory markers were studied at 12 to 15 weeks gestation using biobanked control samples from a randomised trial. Study participants were identified as high risk for GDM using a validated clinical risk prediction tool. Markers were tested using commercial ELISA kits for high molecular weight (HMW) adiponectin, interleukin‐6 (IL‐6), plasminogen activator inhibitor‐1, visfatin, omentin‐1, sex‐hormone binding globulin, monocyte chemoattractant protein, and asymmetrical dimethylarginine. The association between each biomarker and development of GDM at 24 to 28 weeks was evaluated using multivariable logistic regression analysis adjusted for maternal factors.ResultsThere were no differences in age, parity, country of birth, smoking, body mass index, or family history of diabetes in women with normal glucose tolerance (n = 78) and women who developed GDM (n = 25). Women with GDM were more likely to have a past history of GDM (P = 0.004). HMW adiponectin (odds ratio OR 0.37 [95% confidence interval 0.19–0.74]), omentin‐1 (0.97 [0.94–0.99]), and IL‐6 (1.87[1.03–3.37]) were associated with development of GDM, after adjustment for maternal age, body mass index, and past history of GDM. The other markers were not associated with GDM development.ConclusionsDecreased high molecular weight adiponectin and omentin‐1 and increased IL‐6 may enhance sensitivity of early risk prediction tools for women at high risk of GDM. This may allow early identification and opportunities for prevention of GDM and adverse outcomes. Further research is required in large validation studies to confirm these results.
Gut microbiome response to short‐term dietary interventions in reactive hypoglycemia subjects
Authors: Quercia Sara , Turroni Silvia , Fiori Jessica , Soverini Matteo , Rampelli Simone , Biagi Elena , Castagnetti Andrea , Consolandi Clarissa , Severgnini Marco , Pianesi Mario , Fallucca Francesco , Pozzilli Paolo , Brigidi Patrizia , Candela Marco 
Published: August 2017

AbstractBackgroundReactive hypoglycemia is a metabolic disorder that provokes severe hypoglycemic episodes after meals. Over recent years, the gut microbiota has been recognized as potential target for the control of metabolic diseases, and the possibility to correct gut microbiota dysbioses through diet, favouring the recovery of metabolic homeostasis, has been considered.MethodsWe investigate the impact of 2 short‐term (3‐day) nutritional interventions, based on the macrobiotic Ma‐Pi 2 diet and a control Mediterranean diet, on the structure and functionality of the gut microbiota in 12 patients affected by reactive hypoglycemia. The gut microbiota composition was characterized by next‐generation sequencing of the V3 to V4 region of the 16S rRNA gene, and the ecosystem functionality was addressed by measuring the faecal concentration of short‐chain fatty acids (SCFAs). In order to measure the short‐term physiological gut microbiota fluctuation, the microbiomes of 7 healthy people were characterized before and after 3 days of constant diet.ResultsWhile no convergence of the gut microbiota compositional profiles was observed, a significant increase in SCFA faecal levels was induced only in the Ma‐Pi 2 diet group, suggesting the potential of this diet to support a short‐term functional convergence of the gut microbiota, regardless of the individual compositional layout.ConclusionsThe Ma‐Pi 2 diet, with its high fibre load, was effective in increasing the production of SCFAs by the gut microbiota. Because these metabolites are known for their ability to counterbalance the metabolic deregulation in persons with glucose impairment disorders, their increased bioavailability could be of some relevance in reactive hypoglycemia.
Recent advances in amino acid analysis by capillary electromigration methods: June 2015–May 2017
Authors: Poinsot Véréna , Ong‐Meang Varravaddheay , Ric Audrey , Gavard Pierre , Perquis Lucie , Couderc François 
Published: August 2017

AbstractIn the tenth edition of this article focused on recent advances in amino acid analysis using capillary electrophoresis, we describe the most important research articles published on this topic during the period from June 2015 to May 2017. This article follows the format of the previous articles published in Electrophoresis. The new developments in amino acid analysis with CE mainly describe improvements in CE associated with mass spectrometry. Focusing on applications, we mostly describe clinical works, although metabolomics studies are also very important. Finally, works focusing on amino acids in food and agricultural applications are also described.
Analysis of two‐dimensional porous fins with variable thermal conductivity
Authors: Shokouhmand Hossein , Sattari Amirmohammad , Hosseini‐Doost Seyed Erfan , Maghooli Ali 
Published: August 2017

AbstractAnalysis of porous fins for their higher heat transfer in comparison with solid fins with identical volumes has attracted significant attention. In this paper, a two‐dimensional thermal analysis of a porous fin having variable thermal conductivity coefficient is performed using finite difference method. Heat transfer through porous media is simulated using passage velocity from Darcy's model. The thermal conductivity of the solid phase is considered as a linear function of temperature. It is found that the temperature profile of the fin is completely two‐dimensional even for high Rayleigh and Darcy numbers (Ra = 103∼104, Da = 0.01), because the temperature changes significantly along the transverse axis especially for lower Rayleigh and Darcy numbers. Also, the effects of important nondimensional parameters such as Rayleigh and Darcy numbers, porosity, Nusselt, thermal conductivity, and aspect ratio on the temperature profile are investigated. The results demonstrate that the temperature distribution is strongly dependent on the Rayleigh and Darcy numbers.
Hydrological modelling using proxies for gauged precipitation and temperature
Authors: Chen Jie , Brissette François P. 
Published: August 2017

AbstractPrecipitation and temperature time series suffer from many problems, such as short time, inadequate spatial coverage, missing data, and biases from various causes, which are particularly critical in remote areas such as Northern Canada. The development of alternative datasets for using as proxies for inadequate/missing weather data represents a key research area. In this paper, the performance of 6 alternative datasets is evaluated for hydrological modelling over 12 watersheds located across Canada and the contiguous United States. The datasets can be classified into 3 distinct categories: (a) interpolated gridded data, (b) reanalysis data, and (c) climate model outputs. Hydrological simulations were carried out using a lumped conceptual hydrological model calibrated using standard weather data and compared against results using a calibration specific to each alternative dataset. Prior to the hydrological simulations, the alternative datasets were all evaluated with respect to their ability to reproduce gridded daily precipitation and temperature characteristics over North America. The results show that both the reanalysis data and climate model data adequately represent the spatial pattern of daily precipitation and temperature over North America. The North American Regional Reanalysis (NARR) dataset consistently shows the best performance. With respect to hydrological modelling, the observed discharges are accurately represented by both the gridded and NARR datasets, and more so for the NARR data. The National Centers for Environmental Prediction dataset consistently performs worst as it is unable to even capture the seasonal pattern of observed streamflow for 3 out of the 12 watersheds. These results indicate that the NARR dataset could be used as a proxy for gauged precipitation and temperature for hydrological modelling over watersheds where observational datasets are deficient. The results also illustrate the ability of climate model data to be used for performing hydrological modelling when driven by reanalysis data at their boundaries, and especially so for high‐resolution models.
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity
Authors: Holm Anna , Nagaeva Olga , Nagaev Ivan , Loizou Christos , Laurell Göran , Mincheva‐Nilsson Lucia , Nylander Karin , Olofsson Katarina 
Published: August 2017

AbstractObjectivesRecurrent respiratory papillomatosis (RRP) is a relatively rare, chronic disease caused by Human Papilloma Virus (HPV) 6 and 11, and characterized by wart‐like lesions in the airway affecting voice and respiratory function. The majority of HPV infections are asymptomatic and resolve spontaneously, however, some individuals are afflicted with persistent HPV infections. Failure to eliminate HPV 6 and 11 due to a defect immune responsiveness to these specific genotypes is proposed to play a major role in the development of RRP.MethodsWe performed a phenotypic characterization of peripheral blood mononuclear cells (PBMC) collected from 16 RRP patients and 12 age‐matched healthy controls, using immunoflow cytometry, and monoclonal antibodies against differentiation and activation markers. The cytokine mRNA profile of monocytes, T helper‐, T cytotoxic‐, and NK cells was assessed using RT‐qPCR cytokine analysis, differentiating between Th1‐, Th2‐, Th3/regulatory‐, and inflammatory immune responses.ResultsWe found a dominance of cytotoxic T cells, activated NK cells, and high numbers of stressed MIC A/B expressing lymphocytes. There was an overall suppression of cytokine mRNA production and an aberrant cytokine mRNA profile in the activated NK cells.ConclusionThese findings demonstrate an immune dysregulation with inverted CD4+/CD8+ ratio and aberrant cytokine mRNA production in RRP patients, compared to healthy controls.
Resilience in moving water: Effects of turbulence on the predatory impact of the lobate ctenophore Mnemiopsis leidyi
Authors: Jaspers Cornelia , Costello John H. , Sutherland Kelly R. , Gemmell Brad , Lucas Kelsey N. , Tackett Jennifer , Dodge Kara , Colin Sean P. 
Published: August 2017

AbstractDespite its delicate morphology, the lobate ctenophore Mnemiopsis leidyi thrives in coastal ecosystems as an influential zooplankton predator. Coastal ecosystems are often characterized as energetic systems with high levels of natural turbulence in the water column. To understand how natural wind‐driven turbulence affects the feeding ecology of M. leidyi, we used a combination of approaches to quantify how naturally and laboratory generated turbulence affects the behavior, feeding processes and feeding impact of M. leidyi. Experiments using laboratory generated turbulence demonstrated that turbulence can reduce M. leidyi feeding rates on copepods and Artemia nauplii by > 50%. However, detailed feeding data from the field, collected during highly variable surface conditions, showed that wind‐driven turbulence did not affect the feeding rates or prey selection of M. leidyi. Additional laboratory experiments and field observations suggest that the feeding process of M. leidyi is resilient to wind‐driven turbulence because M. leidyi shows a behavioral response to turbulence by moving deeper in the water column. Seeking refuge in deeper waters enables M. leidyi to maintain high feeding rates even under high turbulence conditions generated by wind driven mixing. As a result, M. leidyi exerted a consistently high predatory impact on prey populations during highly variable and often energetic wind‐driven mixing conditions. This resilience adds to our understanding of how M. leidyi can thrive in a wide spectrum of environments around the world. The limits to this resilience also set boundaries to its range expansion into novel areas.
Rewards that undermine customer loyalty? A motivational approach to loyalty programs
Authors: Kim Kyongseok , Ahn Sun Joo (Grace) 
Published: August 2017

AbstractGuided by the framework of self‐determination theory (SDT), this study examined the effects of external rewards on undermining customers’ intrinsic motivation to engage in a retail loyalty program. Two experiments revealed that participants who received a salient, controlling reward (i.e., a promise of reward with an explicit requirement and deadline, without options of choice) reported lower intrinsic motivation to use the loyalty program than participants who received a nonsalient, autonomy‐supportive reward (i.e., a promise of reward with a less explicit requirement and no deadline, with options of choice). However, the undermined intrinsic motivation of those who received the salient, controlling reward was enhanced when they were given verbal feedback acknowledging their potential negative feelings associated with using the loyalty program. These findings provide important practical implications for designing a more effective loyalty program.
Management of osteonecrosis of the femoral head with pedicled iliac bone flap transfer: A multicenter study of 2190 patients
Authors: Zhao Dewei , Xie Hui , Xu Yongqing , Wang Yisheng , Yu Aixi , Liu Youwen , Wang Aimin , He Wei , Wang Xiuli , Li Zirong , Sun Wei , Tian Simiao , Wang Benjie , Liu Baoyi 
Published: August 2017

BackgroundOsteonecrosis of the femoral head (ONFH) often affects young active adults and leads to destruction of the hip joint and disabling arthritis. Several procedures have been developed to arrest the progress of osteonecrosis and postpone the procedure of total hip replacement especially in young patients. The aim of this multicenter study was to analyze the results of the use of the vascularized iliac bone flap transfer for management of ONFH.MethodsFrom January 1985 to December 2012, a total of 2190 patients (2690 hips) with the mean age of 43.15 years (ranging from 18 to 65 years) underwent hip‐preserving surgery with the pedilced iliac bone flap transfer for management of ONFH with Ficat and Arlet stage II–IV in 8 hospitals. There were 1733 hips in stage II, 776 hips in stage III, and 181 hips in stage IV preoperatively. The complications were recorded. The outcomes were evaluated by radiograph, the Harris hip‐scoring system (HHS).ResultsPostoperative complications occurred in 128 patients (5.84%). Among them, 25 patients had deep venous thromboses, 16 patients had sensory deficits, 40 patients had superficial infection and hematoma, and 47 patients had wound dehiscence. A total of 1912 patients (2179 hips) were followed up with a median time of 12 years (ranging from 5 to 25 years). There were 1787 hips with no radiographic osteonecrotic progress during follow‐up, while osteonecrosis progress was observed in 186 hips with stage II (13.1%), 170 hips with stage III (25.6%) and 36 hips with stage IV (36.4%; P < .001). Two hundred fifteen hips (9.87%) in 203 patients were converted to THA during follow‐up, including 19 hips with stage II (1.34%), 162 hips with stage III (24.4%), and 34 hips with stage IV (34.3%).The mean HHS at the end of follow‐up was significantly improved when compared to preoperative mean HHS (83.63 ± 5.03 vs. 66.54 ± 6.05, P < .001).ConclusionsIn this evaluation of a large series of cases, the vascularized iliac bone flap transfer showed good results for arresting the osteonecrosis progress and improving the hip function of patients with pre‐collapse stages of ONFH.
Design, implementation, and performance evaluation of identity‐based cryptography in ONOS
Authors: Lam JunHuy , Lee Sang‐Gon , Lee Hoon‐Jae , Eko Oktian Yustus 
Published: August 2017

SummaryDistributed Software‐Defined Network introduces a new communication channel: the East/West‐bound communication where the controllers synchronize the network information to achieve the logically centralized view of the network. The East/West‐bound communication can be divided into 2 types, the intra‐cluster and inter‐cluster communication. Intra‐cluster communication happens within the control plane while inter‐cluster communication usually happens on the application plane through the northbound communication of each controller. The security of the East/West‐bound communication ensures that no malicious controllers are eavesdropping on or even driving the network. However, most current Software‐Defined Network projects do not implement the security mechanism for the East/West‐bound communication with Open Networking Operating System (ONOS) being the exception. In ONOS, Transport Layer Security (TLS) was used to secure the intra‐cluster communication, but the complicated key management of TLS could be a hindrance for practical implementation. Hence, Identity‐based cryptography protocol was proposed to solve this TLS issue of our previous implementation. In this paper, we have designed, implemented, and evaluated the identity‐based cryptography protocol to secure the East/West‐bound intra‐cluster communication of ONOS.
Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours
Authors: Andrianova Maria A , Chetan Ghati Kasturirangan , Sibin Madathan Kandi , Mckee Thomas , Merkler Doron , Narasinga Rao KVL , Ribaux Pascale , Blouin Jean‐Louis , Makrythanasis Periklis , Seplyarskiy Vladimir B , Antonarakis Stylianos E , Nikolaev Sergey I 
Published: August 2017

AbstractBiallelic mismatch repair deficiency (bMMRD) in tumours is frequently associated with somatic mutations in the exonuclease domains of DNA polymerases POLE or POLD1, and results in a characteristic mutational profile. In this article, we describe the genetic basis of ultramutated high‐grade brain tumours in the context of bMMRD. We performed exome sequencing of two second‐cousin patients from a large consanguineous family of Indian origin with early onset of high‐grade glioblastoma and astrocytoma. We identified a germline homozygous nonsense variant, p.R802*, in the PMS2 gene. Additionally, by genome sequencing of these tumours, we found extremely high somatic mutation rates (237/Mb and 123/Mb), as well as somatic mutations in the proofreading domain of POLE polymerase (p.P436H and p.L424V), which replicates the leading DNA strand. Most interestingly, we found, in both cancers, that the vast majority of mutations were consistent with the signature of POLE exo–, i.e. an abundance of C>A and C>T mutations, particularly in special contexts, on the leading strand. We showed that the fraction of mutations under positive selection among mutations in tumour suppressor genes is more than two‐fold lower in ultramutated tumours than in other glioblastomas. Genetic analyses enabled the diagnosis of the two consanguineous childhood brain tumours as being due to a combination of PMS2 germline and POLE somatic variants, and confirmed them as bMMRD/POLE exo– disorders. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Structure and deformation recovery of the thermoplastic polyurethane spherulite
Authors: Yanagihara Yu , Suenaga Akiko , Kondo Hikari , Saito Hiromu 
Published: August 2017

ABSTRACTWe investigated the structure and deformation behavior of the thermoplastic polyurethane (TPU) spherulite by optical microscopy, tensile testing, Hv light scattering, and small angle X‐ray scattering. The TPU spherulite structure obtained by melt crystallization was coarse consisting of bundle‐like structure containing hard segment (HS) lamellar domain in which the HS domains were stacked and the HS chain direction was perpendicular to the longitudinal axis of the HS domain. By stretching, the spherulite was deformed to ellipsoidal one and the stacked HS lamellar domains were tilted in the stretching direction. The deformed spherulite and the tilted HS domain in the spherulite were recovered to the unstretched state by retraction. The recovery of the structure is ascribed to the characteristic spherulite structure consisting of rubbery soft segment matrix physically cross‐linked with the stacked HS domain. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 1585–1594
Impact of caregiver burden on mental health in bereaved caregivers of cancer patients: A systematic review
Authors: Große Julia , Treml Julia , Kersting Anette 
Published: August 2017

AbstractObjectiveAlthough caregiver burden may continue to influence the mental health of cancer patients' caregivers long after bereavement, few studies have examined this issue.MethodsA systematic review was conducted to provide a summary of (1) operationalizations of caregiver burden used in this field and (2) the effect of caregiver burden on postbereavement mental health of adult caregivers of cancer patients. A systematic search of the electronic databases PubMed, Web of Science, and PsycINFO was conducted across empirical studies published in a peer‐reviewed journal up until April 2017.ResultsCaregiver burden was rarely defined, and it was operationalized in multiple and diverging ways. The 20 included papers present varying results but generally indicate that caregiver burden (especially emotional) has an adverse effect on postbereavement mental health.ConclusionsIn future studies, researchers seeking to ascertain which aspects of caregiver burden may prove an appropriate target for prevention and intervention should first use a precise operational definition of the concept.