bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to chronic variable social stress during adolescence alters affect‐related behaviors and adrenocortical activity in adult male and female inbred mice
Authors: Caruso Michael J. , Kamens Helen M. , Cavigelli Sonia A. 
Published: July 2017

AbstractRodent models provide valuable insight into mechanisms that underlie vulnerability to adverse effects of early‐life challenges. Few studies have evaluated sex differences in anxiogenic or depressogenic effects of adolescent social stress in a rodent model. Furthermore, adolescent stress studies often use genetically heterogeneous outbred rodents which can lead to variable results. The current study evaluated the effects of adolescent social stress in male and female inbred (BALB/cJ) mice. Adolescent mice were exposed to repeat cycles of alternating social isolation and social novelty for 4 weeks. Adolescent social stress increased anxiety‐related behaviors in both sexes and depression‐related behavior in females. Locomotion/exploratory behavior was also decreased in both sexes by stress. Previously stressed adult mice produced less basal fecal corticosteroids than controls. Overall, the novel protocol induced sex‐specific changes in anxiety‐ and depression‐related behaviors and corticoid production in inbred mice. The chronic variable social stress protocol used here may be beneficial to systematically investigate sex‐specific neurobiological mechanisms underlying adolescent stress vulnerability where genetic background can be controlled.
The effects of maternal respiratory sinus arrhythmia and behavioral engagement on mother‐child physiological coregulation
Authors: Skoranski Amanda M. , Lunkenheimer Erika , Lucas‐Thompson Rachel G. 
Published: July 2017

AbstractParent‐child coregulation is thought to be an important precursor for children's developing self‐regulation, but we know little about how individual parent factors shape parent‐child physiological coregulation. We examined whether maternal baseline respiratory sinus arrhythmia (RSA), teaching, and disengagement were associated with stronger or weaker coregulation of RSA between mothers and their 3‐year‐old children (N = 47), modeled across 18 min of observed dyadic interaction using multilevel coupled autoregressive models. Whereas greater maternal teaching was associated with stronger coregulation in mother and child RSA over time, maternal disengagement was related to weaker coregulation, specifically more divergent parent and child RSA at higher levels of maternal disengagement. Coregulation of mother‐child RSA was also weaker when mothers’ baseline RSA was higher. Findings contribute to the emerging knowledge base on real‐time patterns of parent‐child physiological coregulation in early childhood and suggest that mothers’ physiology and behavioral engagement with the child play an important role in mother‐child physiological coregulation patterns.
Experimental characterization and simulation of amino acid and peptide interactions with inorganic materials
Authors: Schwaminger Sebastian , Blank‐Shim Silvia Angela , Borkowska‐Panek Monika , Anand Priya , Fraga‐García Paula , Fink Karin , Wenzel Wolfgang , Berensmeier Sonja 
Published: July 2017

AbstractInspired by nature, many applications and new materials benefit from the interplay of inorganic materials and biomolecules. A fundamental understanding of complex organic–inorganic interactions would improve the controlled production of nanomaterials and biosensors to the development of biocompatible implants for the human body. Although widely exploited in applications, the interaction of amino acids and peptides with most inorganic surfaces is not fully understood. To date, precisely characterizing complex surfaces of inorganic materials and analyzing surface–biomolecule interactions remain challenging both experimentally and computationally. This article reviews several approaches to characterizing biomolecule–surface interactions and illustrates the advantages and disadvantages of the methods presented. First, we explain how the adsorption mechanism of amino acids/peptides to inorganic surfaces can be determined and how thermodynamic and kinetic process constants can be obtained. Second, we demonstrate how this data can be used to develop models for peptide–surface interactions. The understanding and simulation of such interactions constitute a basis for developing molecules with high affinity binding domains in proteins for bioprocess engineering and future biomedical technologies.
Ore genesis of the Xiyi Pb‐Zn deposit, western Yunnan province, China: Geologic, fluid inclusion, and isotopic (C‐H‐O‐S‐Pb) evidence
Authors: Gao Haijun , Zhang Yongmei , Gu Xuexiang , Li Jilin 
Published: July 2017

The Xiyi Pb‐Zn deposit, located in the Baoshan Block of the Sanjiang region in western Yunnan, China, contains 1.2 Mt of Pb‐Zn resources. The orebodies are hosted by Devonian‐Carboniferous limestone, structurally controlled by the NE‐trending fractures, and occur in stratiform, vein, and lenticular forms. The mineral assemblage of the ores includes sphalerite, galena, pyrite, arsenopyrite, chalcopyrite, and marcasite. Calcite, barite, and quartz occur as gangue minerals. Three stages of hydrothermal mineralization are recognized based on the ore textures, crosscutting relationship, and mineral assemblages: an early stage of sphalerite + galena + calcite (Stage 1), a middle stage of galena + arsenopyrite + calcite ± sphalerite (Stage 2), and a late stage of calcite + pyrite ± barite ± quartz (Stage 3). Two types of fluid inclusions are associated with the different ore‐forming hydrothermal stages: aqueous inclusions and hydrocarbon‐H2O inclusions. The ore‐forming fluids were characterized by low temperatures (100 ~ 200 °C), medium salinities (8 ~ 20 wt% NaCleq), and medium densities (1.0 ~ 1.1 g/cm3) and contained minor amounts of CH4. The δDH2O and calculated δ18OH2O values of the Stage 1 calcite range from −89‰ to −103‰ and from 1.5‰ to 5.5‰, respectively, indicating that the H2O in the hydrothermal fluids was derived from seawater that had reacted with organic matter. The δ13CPDB and δ18OSMOW values of the calcite associated with Stages 1 and 3 range from −5.2‰ to 3.2‰ and from 12.5‰ to 20.0‰, respectively. These data plot in the field between marine carbonate and granites and are close to the marine carbonate field, suggesting that the CO2 in the ore‐forming fluids was derived from the dissolution of marine carbonate in the sedimentary rocks. The galena, sphalerite, and pyrite in Stages 1 and 3 have a narrow range of δ34S values (0–3‰), which is lower than the δ34S values of early Carboniferous to Middle‐Late Devonian seawater sulfate (+18‰ to +23‰). Therefore, because the mineralization is unrelated to magmatic activity, the sulfur in the hydrothermal sulfides was derived from regional marine sulfates primarily via organic reduction at temperatures of 100 to 200 °C. The lead isotopic compositions in the galena, sphalerite, and pyrite in Stages 1 and 3 are very similar to those in the diagenetic pyrite in the host rocks, plotting in the field of the upper crust Pb evolution curve. Thus, the lead source was likely the Carboniferous and Devonian strata. The geologic, fluid inclusion, and isotopic (C‐H‐O‐S‐Pb) evidence in this study suggests that the Xiyi Pb‐Zn deposit is a Mississippi Valley‐type deposit.
Impairment in predictive processes during auditory mismatch negativity in ScZ: Evidence from event‐related fields
Authors: Sauer Andreas , Zeev‐Wolf Maor , Grent‐'t‐Jong Tineke , Recasens Marc , Wacongne Catherine , Wibral Michael , Helbling Saskia , Peled Abraham , Grinshpoon Alexander , Singer Wolf , Goldstein Abraham , Uhlhaas Peter J. 
Published: July 2017

AbstractPatients with schizophrenia (ScZ) show pronounced dysfunctions in auditory perception but the underlying mechanisms as well as the localization of the deficit remain unclear. To examine these questions, the current study examined whether alterations in the neuromagnetic mismatch negativity (MMNm) in ScZ‐patients could involve an impairment in sensory predictions in local sensory and higher auditory areas. Using a whole‐head MEG‐approach, we investigated the MMNm as well as P300m and N100m amplitudes during a hierarchical auditory novelty paradigm in 16 medicated ScZ‐patients and 16 controls. In addition, responses to omitted sounds were investigated, allowing for a critical test of the predictive coding hypothesis. Source‐localization was performed to identify the generators of the MMNm, omission responses as well as the P300m. Clinical symptoms were examined with the positive and negative syndrome scale. Event‐related fields (ERFs) to standard sounds were intact in ScZ‐patients. However, the ScZ‐group showed a reduction in the amplitude of the MMNm during both local (within trials) and global (across trials) conditions as well as an absent P300m at the global level. Importantly, responses to sound omissions were reduced in ScZ‐patients which overlapped both in latency and generators with the MMNm sources. Thus, our data suggest that auditory dysfunctions in ScZ involve impaired predictive processes that involve deficits in both automatic and conscious detection of auditory regularities. Hum Brain Mapp 38:5082–5093, 2017. © 2017 Wiley Periodicals, Inc.
Partial volume model for brain MRI scan using MP2RAGE
Authors: Duché Quentin , Saint‐Jalmes Hervé , Acosta Oscar , Raniga Parnesh , Bourgeat Pierrick , Doré Vincent , Egan Gary F. , Salvado Olivier 
Published: July 2017

AbstractMP2RAGE is a
weighted MRI sequence that estimates a composite image providing much reduction of the receiver bias, has a high intensity dynamic range, and provides an estimate of
mapping. It is, therefore, an appealing option for brain morphometry studies. However, previous studies have reported a difference in cortical thickness computed from MP2RAGE compared with widely used Multi‐Echo MPRAGE. In this article, we demonstrated that using standard segmentation and partial volume estimation techniques on MP2RAGE introduces systematic errors, and we proposed a new model to estimate partial volume of the cortical gray matter. We also included in their model a local estimate of tissue intensity to take into account the natural variation of tissue intensity across the brain. A theoretical framework is provided and validated using synthetic and physical phantoms. A repeatability experiment comparing MPRAGE and MP2RAGE confirmed that MP2RAGE using our model could be considered for structural imaging in brain morphology study, with similar cortical thickness estimate than that computed with MPRAGE. Hum Brain Mapp 38:5115–5127, 2017. © 2017 Wiley Periodicals, Inc.
Reduction of Sugarcane Water Footprint by Controlled Drainage, in Khuzestan, Iran
Authors: Jahani Babak , Soltani Mohammadi Amir , Nasseri Abd Ali , Van Oel Pieter R. , Sadeghi Lari Adnan 
Published: July 2017

AbstractThe main objective of this study was to estimate the different components of the water footprint for sugarcane production under the conditions of free (FD) and controlled drainage (as an on‐farm strategy for agricultural water management, CD) in an arid and semi‐arid region in the south‐west of Iran (Khuzestan Province). The different components of the water footprint (green, blue and grey) were assessed based on on‐farm measurements. The total amount of water footprint for sugarcane production in the study area stood at 250 m3t−1 in the treatment FD. Of this, 12.2, 71.8 and 16.0% were of the green, blue and grey water footprints, respectively. By using CD this value was reduced to 203 m3t−1 in total, of which, 13.7, 76.8 and 9.5% were of the green, blue and grey water footprints, respectively. This decrease in the amount of water footprint seems to be mainly a result of an increase in crop productivity (due to soil condition improvement), reduction of the in‐ and outflow of the sugarcane farm and also reduction of nitrate losses in the CD treatment. Copyright © 2017 John Wiley & Sons, Ltd.
Difference‐in‐differences when the treatment status is observed in only one period
Authors: Botosaru Irene , Gutierrez Federico H. 
Published: July 2017

SummaryThis paper considers the difference‐in‐differences (DID) method when the data come from repeated cross‐sections and the treatment status is observed either before or after the implementation of a program. We propose a new method that point‐identifies the average treatment effect on the treated (ATT) via a DID method when there is at least one proxy variable for the latent treatment. Key assumptions are the stationarity of the propensity score conditional on the proxy and an exclusion restriction that the proxy must satisfy with respect to the change in average outcomes over time conditional on the true treatment status. We propose a generalized method of moments estimator for the ATT and we show that the associated overidentification test can be used to test our key assumptions. The method is used to evaluate JUNTOS, a Peruvian conditional cash transfer program. We find that the program significantly increased the demand for health inputs among children and women of reproductive age.
Endocrine disruption: In silico interactions between phthalate plasticizers and corticosteroid binding globulin
Authors: Sheikh Ishfaq A. , Beg Mohd A. 
Published: July 2017

AbstractEndocrine disruption is a phenomenon when a man‐made or natural compound interferes with normal hormone function in human or animal body systems. Endocrine‐disrupting compounds (EDCs) have assumed considerable importance as a result of industrial activity, mass production of synthetic chemicals and environmental pollution. Phthalate plasticizers are a group of chemicals used widely and diversely in industry especially in the plastic industry, and many of the phthalate compounds have endocrine‐disrupting properties. Increasing evidence indicates that steroid nuclear receptors and steroid binding proteins are the main targets of endocrine disruption. Corticosteroid‐binding globulin (CBG) is a steroid binding protein that binds and transports cortisol in the blood circulation and is a potential target for endocrine disruption. An imbalance of cortisol in the body leads to many health problems. Induced fit docking of nine important and environmentally relevant phthalate plasticizers (DMP, BBP, DBP, DIBP, DnHP, DEHP, DINP, DnOP, DIDP) showed interactions with 10–19 amino acid residues of CBG. Comparison of the interacting residues of CBG with phthalate ligands and cortisol showed an overlapping of the majority (53–82%) of residues for each phthalate. Five of nine phthalate compounds and cortisol shared a hydrogen bonding interaction with the Arg‐252 residue of CBG. Long‐chain phthalates, such as DEHP, DINP, DnOP and DIDP displayed a higher binding affinity and formed a number of interactions with CBG in comparison to short‐chain phthalates. The similarity in structural binding characteristics of phthalate compounds and native ligand cortisol suggested potential competitive conflicts in CBG‐cortisol binding function and possible disruption of cortisol and progesterone homeostasis.
Increased incidence of non‐alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis
Authors: De Long Nicole E. , Hardy Daniel B. , Ma Noelle , Holloway Alison C. 
Published: July 2017

AbstractUp to 10% of women take selective serotonin reuptake inhibitors (SSRI) during pregnancy. Children exposed to SSRIs in utero have an increased risk of being overweight suggesting that fetal exposure to SSRIs can cause permanent metabolic changes. We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non‐alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to identify the mechanism(s) underlying the fluoxetine‐induced increase in intrahepatic triglyceride content. Female nulliparous Wistar rats were given vehicle or fluoxetine (10 mg/kg/day) orally for 2 weeks prior to mating until weaning. At 6 months of age, we assessed whether SSRI exposure altered components of the hepatic triglyceride biosynthesis pathway in the offspring and examined the molecular mechanisms underlying these changes. Male SSRI‐exposed offspring had a significant increase in the steady‐state mRNA levels of Elovl6 and Dgat1 and core components of the NLRP3 inflammasome (apoptosis‐associated speck‐like protein containing a caspase activation recruitment domain [ASC] and caspase‐1). Augmented expression of Asc in the SSRI‐exposed offspring coincided with increased histone acetylation in the proximal promoter region. Given that we have previously demonstrated that antenatal exposure to SSRIs can lead to fatty liver in the offspring, this raises concerns regarding the long‐term metabolic sequelae of fetal SSRI exposure. Moreover, this study suggests that elevated hepatic triglyceride levels observed in the SSRI‐exposed offspring may be due, in part, to activation of the NLRP3 inflammasome and augmentation of de novo lipogenesis.
A Cross‐Study Analysis Evaluating the Effects of Food on the Pharmacokinetics of Rivaroxaban in Clinical Studies
Authors: Zhang Liping , Peters Gary , Haskell Lloyd , Patel Purve , Nandy Partha , Moore Kenneth Todd 
Published: July 2017

AbstractUS prescribing guidelines recommend that 15‐ and 20‐mg doses of rivaroxaban be administered with food for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and for reduction in the risk of recurrence of DVT and PE. In addition, the US prescribing guidelines recommend these doses be administered with an evening meal to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF). The purpose of this model‐based cross‐study comparison was to examine the impact of food, with regard to both meal timing and content, on the pharmacokinetics (PK) of rivaroxaban, using data collected during its clinical development. Results of this analysis showed that a PK model built from pooled data in the AF population (for whom rivaroxaban was administered with an evening meal) and in the DVT population (for whom rivaroxaban was administered with a morning meal) can describe both data sets well. Furthermore, the PK model built from data in the AF population alone can adequately predict the PK profile of the DVT population and vice versa. This cross‐study analysis also confirmed the findings from previous clinical pharmacology studies, which showed that meal content does not have a clinically relevant impact on the PK of rivaroxaban at 20 mg. Therefore, although the administration of rivaroxaban with food is necessary for maintaining high bioavailability, neither meal timing nor meal content appears to affect the PK of rivaroxaban.
Calcifying epithelioma of malherbe (Pilomatrixoma): Clinical and sonographic features
Authors: Lin Sai‐Feng , Xu Shi‐Hao , Xie Zuo‐Liu 
Published: July 2017

ABSTRACTPurposeThe purpose of this study was to describe the clinical and sonographic features of calcifying epitheliomas (pilomatrixomas).MethodsWe retrospectively reviewed the clinical data and sonographic appearances of 59 cases of calcifying epitheliomas in 58 patients that were confirmed pathologically.ResultsThe mean age of the patients was 26 years (range, 5–69 years) and the female‐to‐male ratio was 1.2. All masses were located in subcutaneous soft tissues. Overall, 76.3% of the cases were located in the head and neck; the mean tumor size was 13 mm, and 72.9% of the cases were between 10 and 20 mm in size. Of the lesions, 62.7% were hypoechoic masses with internal calcifications, and 74.6% of them showed low or moderate internal vascularity on Doppler imaging.ConclusionsThe diagnosis of calcifying epithelioma should be considered in a patient with a painless, circumscribed, oval‐shaped hypoechoic mass with internal calcifications and internal vascularity in the subcutaneous soft tissues of the head or neck. The mass may be small and have well‐defined margins, with hypoechogenicity. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46:3–7, 2018;
Major role of water bodies on diurnal precipitation regimes in Eastern Africa
Authors: Camberlin Pierre , Gitau Wilson , Planchon Olivier , Dubreuil Vincent , Funatsu Beatriz M. , Philippon Nathalie 
Published: July 2017

ABSTRACTMean diurnal rainfall regimes over Eastern Africa (also referred to as the Greater Horn of Africa) are studied based on 3‐hourly data from the TRMM 3B42 data set, averaged over a 17‐year period (1998–2014). The consistency with long‐term mean raingauge data, available for partly independent periods, varies from good (Sudan, Ethiopia, Eritrea and Somalia) to very good (Kenya, Tanzania and Uganda). Over sea (Indian Ocean and Red Sea), the diurnal rainfall distribution is quite uniform; however, a morning peak dominates and there is evidence of offshore phase propagation south of the equator. Over land, both rainfall frequency and rainfall amounts show a dominant afternoon maximum (1500–1800 East African Time, i.e. GMT + 3). However, many inland regions show a delayed rainfall maximum (evening, night‐time or morning). The evening to night‐time maximum found over some land areas is associated with a phase propagation from areas showing an afternoon peak. This occurs west of high ground areas (Sudan and parts of the Great Lakes region) and in belts parallel to the seashores (Eritrea, northeastern Ethiopia, Somalia and eastern Kenya). The latter provide indirect evidence that sea breeze effects can be detected at unexpectedly great distances from the coast (up to 300–400 km) in parts of Eastern Africa. A remarkable ring of early afternoon (1500) maxima is found around most lakes, although some east–west asymmetries occur. Over the lakes, a morning or late night maximum is mostly found. It is generally inversely related to the distance to the shorelines for the larger lakes, but over the mid‐size lakes it is replaced by or competes with a late afternoon to evening maximum.
An exploration of crowdsourcing citation screening for systematic reviews
Authors: Mortensen Michael L. , Adam Gaelen P. , Trikalinos Thomas A. , Kraska Tim , Wallace Byron C. 
Published: July 2017

Systematic reviews are increasingly used to inform health care decisions, but are expensive to produce. We explore the use of crowdsourcing (distributing tasks to untrained workers via the web) to reduce the cost of screening citations. We used Amazon Mechanical Turk as our platform and 4 previously conducted systematic reviews as examples. For each citation, workers answered 4 or 5 questions that were equivalent to the eligibility criteria. We aggregated responses from multiple workers into an overall decision to include or exclude the citation using 1 of 9 algorithms and compared the performance of these algorithms to the corresponding decisions of trained experts. The most inclusive algorithm (designating a citation as relevant if any worker did) identified 95% to 99% of the citations that were ultimately included in the reviews while excluding 68% to 82% of irrelevant citations. Other algorithms increased the fraction of irrelevant articles excluded at some cost to the inclusion of relevant studies. Crowdworkers completed screening in 4 to 17 days, costing $460 to $2220, a cost reduction of up to 88% compared to trained experts. Crowdsourcing may represent a useful approach to reducing the cost of identifying literature for systematic reviews.