bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Severe Postpartum Hemorrhage After Cesarean Delivery: Case-Control Studies
Authors: Butwick Alexander J. , Ramachandran Bharathi , Hegde Priya , Riley Edward T. , El-Sayed Yasser Y. , Nelson Lorene M. 
Published: March 2017

BACKGROUND:
Women who undergo intrapartum caesarean delivery (CD) are at increased risk of postpartum hemorrhage (PPH) compared with those undergoing prelabor CD. To determine whether the presence and strength of the associations between individual risk factors and severe PPH vary among women undergoing prelabor CD or intrapartum CD, stratified analyses are needed according to CD subtype.

METHODS:
To identify risk factors for severe PPH within 2 distinct CD populations, prelabor CD and intrapartum CD, we performed 2 case-control studies. Women in each study cohort delivered at a tertiary obstetric center in the United States between 2002 and 2012. For each study, cases were women who had a blood loss ≥1500 mL or who received an intraoperative or postoperative transfusion up to 48 hours after delivery. Risk factors for severe PPH among women undergoing prelabor CD or intrapartum CD were examined in separate logistic regression models.

RESULTS:
For prelabor CD, we identified 269 cases and 550 controls. Clinical factors with the highest adjusted odds for severe PPH during prelabor CD were general anesthesia (adjusted odds ratio [aOR] = 22.3; 95% confidence interval [CI], 4.9–99.9; reference group = spinal anesthesia), multiple pregnancies (aOR = 8.0; 95% CI, 4.2–15.0; reference group = singleton pregnancy), and placenta previa (aOR = 6.3; 95% CI, 3.4–11.8). For intrapartum CD, we identified 278 cases and 572 controls. Clinical factors with the highest adjusted odds for severe PPH during intrapartum CD were general anesthesia (aOR = 5.4; 95% CI, 1.7–17.1), multiple pregnancies (aOR = 3.2; 95% CI, 1.7–6.3), and a predelivery hemoglobin ≤ 9.9 g/dL (aOR = 3.0; 95% CI, 1.3–6.9; reference group = predelivery hemoglobin ≥ 11 g/dL).

CONCLUSIONS:
Women who undergo prelabor CD and intrapartum CD have several shared risk factors for severe PPH (general anesthesia and multiple pregnancies). However, the risk factor profiles for severe PPH differed between these CD cohorts. Recognizing these differences may be important when planning resources and interventions for high-risk patients undergoing either prelabor or intrapartum CD.
Preventing facial pressure ulcers in patients under non-invasive mechanical ventilation: a randomised control trial
Authors: Otero D. Peña , Domínguez D. Vazquez , Fernández L. Hernanz , Magariño A. Santano , González V. Jimenez , Klepzing J.V. García , Montesinos J.V. Beneit 
Published: March 2017

Objective:To comparatively assess the efficacy of four different therapeutic strategies to prevent the development of facial pressure ulcers (FPUs) related to the use of non-invasive mechanical ventilation (NIV) with oro-nasal masks in critically ill hospitalised patients.Method:This randomised control trial was performed at the high dependency unit in the University General Hospital Gregorio Marañón in Madrid, Spain. Overall, 152 patients with acute respiratory failure were recruited. All patients were hospitalised and received NIV through oro-nasal masks. The Norton tool was used to evaluate the general risk of developing pressure ulcers (PUs). Subjects were divided into four groups, each of them receiving a different treatment. Tissue assessment and preventive care were performed by a member of the research team.Results:The incidence of FPUs was significantly lower in the group receiving a solution of hyperoxygenated fatty acids (HOFA) when compared with each of the other therapeutic strategies: direct mask (p=0.055), adhesive thin dressing (p=0.03) and adhesive foam dressing (p<0.001).Conclusion:The application of HOFA on the facial skin in contact with the oro-nasal masks showed the highest efficacy in the prevention of NIV-related FPUs.
Adjunct Analgesic Use for Acute Pain in the Emergency Department
Authors: Priano James , Faley Brian , Procopio Gabrielle , Hewitt Kevin , Feldman Joseph 
Published: March 2017

Purpose Multimodal analgesia is common practice in the postoperative setting, but the utility of adjunctive analgesia in the emergency department (ED) is less understood. The primary objective of this study was to analyze ED prescriber ordering habits for adjunct nonopioid pain medication for opioid-naïve patients who require intravenous (IV) morphine or hydromorphone for acute pain. Secondary objectives were to assess initial and total opioid consumption in morphine equivalent units (MEU), pain scores, and ED length of stay (LOS) between groups. Methods A retrospective chart review of adult patients who presented to the ED at a large academic medical center and received IV morphine or hydromorphone for acute pain was conducted. Patients were analyzed according to initial opioid received and presence or absence of adjunct nonopioid analgesics. Results A total of 102 patient charts were analyzed. Adjunctive nonopioid analgesics were ordered on 38% of patients. Patients who received an adjunct nonopioid analgesic received a smaller mean initial opioid dose than those who did not (4.73 vs 5.48 MEU, p = .08). Initial pain score reduction on the 11-point Numeric Rating Scale (NRS) did not differ between patients who received adjunct analgesics versus those who did not (3 vs 4, p = .75). Patients who received adjunct analgesics were associated with a decreased ED LOS (294 vs 342 minutes, p = .04). Conclusion A small proportion of patients with acute pain received a nonopioid analgesic in conjunction to IV opioids. Further studies are warranted to assess the impact of adjunct analgesics for patients with acute pain.
Preventing 10-fold Dosage Errors; Controlled Substances at Bedside or Procedural Area; Genvoya-Stribild Mix-up; Should Transdermal Fentanyl be Stocked in the ED?
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: March 2017

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Thyrotropin-producing adenoma. Report of two clinical cases
Authors: Karapetyan Ani R. , Gormolysova Ekaterina V. , Galushko Eugeniy V. 
Published: March 2017

Диагностика тиреотоксикоза в настоящее время не представляет серьезных трудностей. Распространение методов визуализации с каждым годом увеличивает выявляемость аденом гипофиза. Тиреотропинома – редкая причина тиреотоксикоза.Ранняя диагностика ТТГ-секретирующей аденомы предупредит ошибки в лечебной тактике, приводящие к необоснованному хирургическому вмешательству на щитовидной железе, и позволит повысить качество жизни пациентов. В статье приведены два клинических случая ТТГ-секретирующих аденом гипофиза у пациенток с различной длительностью заболевания и, соответственно, размерами аденом, наличием осложнений тиреотоксикоза. Обе пациентки были оперированы в Федеральном Центре Нейрохирургии г. Новосибирска из трансназального транссфеноидального доступа. В послеоперационном периоде достигнут стойкий эутиреоз в обоих случаях. У пациентки с многолетним анамнезом заболевания, большими размерами аденомы в послеоперационном периоде развился вторичный гипокортицизм, а качество ее жизни значительно ниже, учитывая сопутствующую патологию. Период дальнейшего наблюдения этих случаев составил 3 года и год соответственно.
Retirement Decisions in Recessionary Times: Evidence from Spain
Authors: Amuedo-Dorantes Catalina , Borra Cristina 
Published: March 2017

Abstract
The recession that started in the United States in December 2007 has had a significant impact on the Spanish economy through a large increase of the unemployment rate and the bursting of the housing and financial bubbles. We explore how the crisis and changes in the labor, housing, and financial markets might have impacted retirement patterns of Spanish men and women nearing retirement age. We find that the recession primarily reduced women’s retirement likelihood by 27%. The effect, which was associated with the labor market deterioration, as captured by higher unemployment rates, was circumscribed to women already at work, who chose to stay at work longer. In contrast, for the most part, men’s retirement likelihood did not change with the labor, housing, and financial market fluctuations. Overall, the findings suggest that working women might have prolonged their working lives to make up for lost household income.
The MEFV gene pathogenic variants and phenotype-genotype correlation in children with familial Mediterranean fever in the Çanakkale population
Authors: Battal F , Silan F , Topaloğlu N , Aylanç H , Yıldırım Ş , Köksal Binnetoğlu F , Tekin M , Kaymaz N , Ozdemir O 
Published: March 2017

Abstract
The aim of the current study was to determine the frequency of the Mediterranean fever (MEFV) gene pathogenic variants in 60 children diagnosed with familial Mediterranean fever (FMF) and to compare the phenotype-genotype correlation. Genomic DNA was isolated by the spin-column method from peripheral blood samples (collected in vacutainers containing EDTA) and buccal smears. The MEFV gene profiles for the current FMF cohort were genotyped by pyrosequencing and direct Sanger sequencing techniques for the target pathogenic variants. The most prominent clinical symptoms were abdominal pain (53.4%), fever (23.4%) and arthritis (23.3%). Eighteen different pathogenic variants were identified and the most frequent were p.Met694Val (20.0%), p.Glu148Gln (13.3%), p.Met680 Ile (11.7%) and p.Arg202Gln (11.7%). Abdominal pain, fever and arthritis were the most common presenting clinical characteristics. Results showed that not only clinical characteristics, but also genotyping of the MEFV gene is needed to establish the correct diagnosis of FMF in children and other family members.
The genetic background of Southern Iranian couples before marriage
Authors: Nariman A , Sobhan MR , Savaei M , Aref-Eshghi E , Nourinejad R , Manoochehri M , Ghahremani S , Daliri F , Daliri K 
Published: March 2017

Abstract
Genetic service for couples plays an increasingly important role in diagnosis and risk management. This study investigated the status of consanguinity and the medical genetic history (effectiveness and coverage of medical genetic services) in couples residing in a city in southern Iran. We questioned couples who were referred to Behbahan Marital Counseling Center, Behbahan, Iran, during the period from January to November 2014, to obtain information on consanguinity, disease history, and previous referral to a medical genetics center. For the collected data was obtained descriptive statistics with STATA 11.0 software. A total of 500 couples were questioned. Mean age was 24.8 ± 5.2 years. Almost one quarter (23.4%) of the couples were consanguineous. Consanguinity was almost twice as common in rural areas as in urban areas (33.9 vs. 19.2%, p = 0.001). Only a few couples (~3.0%) had ever been referred for genetic counseling. The main reason for previous genetic counseling was consanguinity (85.7%). The majority of the participants (96.3%) had never been tested for any genetic conditions. Our findings suggest that only a small proportion of couples in Khuzestan Province, Iran (Behbahan City) were receiving adequate genetics care. This may reflect the limited accessibility of such services, and inadequate awareness and education among the care providers.
A 9-year-old-girl with Phelan McDermid Syndrome, who had been diagnosed with an autism spectrum disorder
Authors: Görker I , Gürkan H , Demir Ulusal S , Atlı E , Ikbal Atlı E 
Published: March 2017

Abstract
Phelan McDermid Syndrome (PHMDS) (OMIM #606232), is a contiguous gene disorder resulting from deletion of the distal long arm of chromosome 22. The 22q13.3 deletions and mutations that lead to a loss of a functional copy of SHANK3 (OMIM *606230) cause the syndrome, characterized by moderate to profound intellectual disability, severely delayed or absent speech, hypotonia, and autism spectrum disorder (ASD) or ASD traits. In this study, we present the case of a 9-year-old girl who had earlier been diagnosed with an ASD. Our findings were a clinically mild intellectual disability, rounded face, pointed chin but no autistic findings. We learned that her neuromotor development was delayed and she had neonatal hypotonia in her history. A heterozygous deletion of MLC1, SBF1, MAPK8IP2, ARSA, SHANK3 and ACR genes, located on 22q13.33, was defined by multiplex ligation-dependent probe amplification (MLPA). Deletion of 22q13.3 (ARSA) region was confirmed by a fluorescent in situ hybridization (FISH) technique. The 22q13.3 deletion was found to be de novo in our patient, and she was diagnosed with PHMDS. We confirmed the 22q13.3 deletion and also determined a gain of 8p23.3-23.2 by array comparative genomic hybridization (aCGH). Fluorescent in situ hybridization was performed to determine whether the deletion was of parental origin and to identify regions of chromosomes where the extra 8p may have been located. The parents were found to be normal. The extra copy of 8p was observed on 22q in the patient. She is the first case reported in association with the 22q deletion of 8p duplications in the literature.
A novel intronic splice site tafazzin gene mutation detected prenatally in a family with Barth syndrome
Authors: Bakšienė M , Benušienė E , Morkūnienė A , Ambrozaitytė L , Utkus A , Kučinskas V 
Published: March 2017

Abstract
Barth syndrome (BTHS) is a rare X-linked disease characterized by dilated cardiomyopathy, proximal skeletal myopathy and cyclic neutropenia. It is caused by various mutations in the tafazzin (TAZ) gene located on Xq28 that results in remodeling of cardiolipin and abnormalities in mitochondria stability and energy production. Here we report on a novel c.285-1G>C splice site mutation in intron 3 of the TAZ gene that was detected prenatally.
Periodontal ligament stem cells regulate apoptosis of neutrophils
Authors: Wang Qing , Ding Gang , Xu Xin 
Published: March 2017

AbstractPeriodontal ligament stem cells (PDLSCs) are promising cell resource for the cell-based therapy for periodontitis and regeneration of bio-root. In this study, we investigated the effect of PDLSCs on neutrophil, a critical constituent of innate immunity, and the underlying mechanisms. The effect of PDLSCs on the proliferation and apoptosis of resting neutrophils and IL-8 activated neutrophils was tested under cell-cell contact culture and Transwell culture, with or without anti-IL-6 neutralizing antibody. We found that PDLSCs could promote the proliferation and reduce the apoptosis of neutrophils whether under cell-cell contact or Transwell culture. Anti-IL-6 antibody reduced PDLSCs-mediated inhibition of neutrophil apoptosis. IL-6 at the concentration of 10ng/ml and 20ng/ml could inhibit neutrophil apoptosis statistically. Collectively, PDLSCs could reduce the apoptosis of neutrophils via IL-6.
Crystal structure of (bis(2,2′-bipyridine-κ
2
N,N′))-(3,5-dinitrosalicylato-κ
2
O,O′)nickel(II), C27H18N6NiO7
Authors: Xie Guixiang , Tang Zhiwei , Dong Yan , Wen Decai 
Published: March 2017

Abstract
C27H18N6NiO7, monoclinic, P21/n (no. 14), a = 8.0981(15) Å, b = 21.660(3) Å, c = 14.170(2) Å, β = 95.215(4)°, V = 2475.1(7) Å3, Z = 4, R
gt(F) = 0.0418, wR
ref(F
2) = 0.0965, T = 293 K.
A mathematical/physics model to measure the role of information and communication technology in some economies: the Chinese case
Authors: Lin Xuchen , Lu Ting-Jie , Chen Xia 
Published: March 2017

Abstract
Since the Reform and Opening-up in 1978, China has experienced a huge sustainable growth of gross domestic product (GDP) and an incredible development in Information and Communication Technology (ICT). This study aims to utilize an input-output (I-O) approach to explore the role of ICT in Chinese national economy. Specifically, we employ a static I-O framework, and analyze three topics in its application: the inter-industry linkage effect, the production inducing effect, and the supply shortage effect. We pay particular attention to the ICT manufacturing sector and ICT service-providing sector by taking the sectors as exogenous and investigating their economic impacts, respectively. The results suggest that (1) the ICT manufacturing sector has a high backward linkage effect, an intermediate forward linkage effect, a relatively low production inducing effect, and a low supply shortage effect, it suggests that ICT manufacturing sector has a powerful capacity for pulling the production activities of the whole economy. (2) The inter-industry linkage effect and supply shortage effect of ICT service-providing is low, but the production inducing effect of ICT service-providing is high, which suggests that the impact of an increase in ICT service-providing investment on the total output of all other sectors is large.
Effects of Sparring Load on Reaction Speed and Punch Force During the Precompetition and Competition Periods in Boxing
Authors: Hukkanen Esa , Häkkinen Keijo 
Published: March 2017

Abstract
Hukkanen, E and Häkkinen, K. Effects of sparring load on reaction speed and punch force during the precompetition and competition periods in boxing. J Strength Cond Res 31(6): 1563–1568, 2017—Seven, male, national-level boxers (age, 20.3 ± 2.7 years; height, 1.80 ± 0.06 m; mass, 73.8 ± 11.1 kg) participated in this study to investigate the effects of sparring on reaction time and punch force of straight punches measured during the precompetition and competition periods. Heart rate and blood lactate concentrations were also monitored. Sparring load was chosen in accordance with the current rules: 3 × 3-minute bouts with 1-minute break in between. Reaction time of rear straight lengthened (p < 0.01) during the sparring load of the precompetition period after the third round (to 390 milliseconds) in comparison to the competition period (to 310 milliseconds). Reaction time of lead straight lengthened (p ≤ 0.05) between the first and third round during the precompetition with no differences during the competition period. Both rear and lead straight punch forces were greater at all measurement points during the precompetition compared with the competition period. Punch forces increased for both rear and lead straight between the first and third rounds with the highest forces after third round during the precompetition (rear straight, 209 kg) and competition (rear straight, 176 kg) periods. Blood lactate levels increased after every round during both periods being at its greatest after the third round (17 mmol·L−1 during the precompetition and 13 mmol·L−1 during the competition period). The present sparring-induced differences in reaction time and punch forces of straight punches during the precompetition compared with the competition period may be the result of different volume and intensity of training with different goals in boxing-specific and explosive strength training.
Validity of Single-Beam Timing Lights at Different Heights
Authors: Altmann Stefan , Spielmann Max , Engel Florian Azad , Neumann Rainer , Ringhof Steffen , Oriwol Doris , Haertel Sascha 
Published: March 2017

Abstract
Altmann, S, Spielmann, M, Engel, FA, Neumann, R, Ringhof, S, Oriwol, D, and Haertel, S. Validity of single-beam timing lights at different heights. J Strength Cond Res 31(7): 1994–1999, 2017—The purpose of this study was to quantify the effect of different timing light heights on sprint time and the validity of measurement. Two single-beam timing gate systems were used to measure 30-m sprint time (splits at 5 and 10 m) in 15 healthy and physically active male subjects. System 1 was set up at a height of 0.64 m and system 2 at 0.25 m (initial timing light) and 1.00 m (each following timing light), respectively. Participants performed 3 valid trials. The recordings of a high-speed video camera were used as a reference. Sprint times of system 1 and system 2 differed significantly between each other and from the reference system at all distances (p < 0.001). Intraclass correlation coefficients and Pearson's r values between both timing light systems and the reference system were low to moderate at 5 and 10 m and moderate to high at 30 m. Bland and Altman analysis revealed that the agreement intervals were considerably higher for the comparison between system 1 and the reference system than for system 2 and the reference system. A valid measurement of splits at 5 and 10 m via the systems used in this study is questionable, whereas 30-m times have an acceptable validity, especially when using system 2. This study confirms the influence of methodological approaches on sprint times. Coaches and researchers should consider that results gained by single-beam timing lights at different heights are not comparable.
Changes in Unilateral Upper Limb Muscular Strength and Electromyographic Activity After a 16-Week Strength Training Intervention in Survivors of Breast Cancer
Authors: Hagstrom Amanda D. , Shorter Kathleen A. , Marshall Paul W.M. 
Published: March 2017

Abstract
Hagstrom, AD, Shorter, KA, and Marshall, PWM. Changes in unilateral upper limb muscular strength and Electroymographic activity after a 16-week strength training intervention in survivors of breast cancer. J Strength Cond Res 33(1): 225–233, 2019—Upper limb strength deficits are frequently observed following breast cancer (BC) and its treatments. It is currently unknown whether these unilateral deficits can be corrected by a standard bilateral strength training intervention. Twenty-three survivors of BC were included in this analysis. Fourteen performed a 16-week resistance training (RT) intervention, 9 were assigned to a usual care waitlist control group. Electromyographic analysis of the pectoralis major and triceps brachii were monitored during 3 maximal isometric contractions and a fatiguing endurance task. Muscular strength was significantly different between limbs at the start of the intervention (p = 0.02). Electromyographic amplitude and median frequency did not differ between limbs at the start of the intervention. Muscular strength was significantly different between limbs in the RT group at the end of the intervention (p = 0.01). Electromyographic amplitude did not differ between limbs or groups at the end of the intervention. Bilateral strength training did not correct the unilateral strength deficit observed in this group of survivors of breast cancer. Periods of unilateral strength training should be implemented into periodized RT programs in this cohort.