bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestures as Archives: Truth, Loss, and Resistance
Authors: Popa Delia 
Published: September 2024

AbstractIn this paper, I develop a phenomenological investigation of gestures that focuses on their temporal formation and their historical sedimentation. My approach combines a genetic phenomenological analysis with psychoanalytic investigations, to elaborate on the idea of an archeology of gestures that explores the hidden historicity of their fugitive expression and the consistent patterns of their bodily manifestation. The paper examines four aspects of gestures—hovering, exhibition, mimesis, and resistance—in order to question their relationship to truth. In the last part of the paper, I explore the role of gestures in difficult processes of mourning and melancholia, focusing on the somatic incorporation of a lost other in oneself. In the light of these analyses, I propose to consider gestures as bodily archives that speak for cryptic inscriptions of past experiences, whose role is to keep alive a past that we cannot let go but also for emancipatory transitions toward new horizons, where the sense of our experience can finally be conquered as our own.
Assessing Organizations as Responsible Entities Adequately. A Practice-Based Approach to Organizational Agency
Authors: Jungmann Robert 
Published: September 2024

AbstractIn complex settings, organizations overlap with other collective entities in time and space even as they struggle for visibility or invisibility as relevant entities. Moreover, they do not act as legal persons or complete organizational actors all the time. Such settings give rise to a question that bears on the fundamental question of adequately identifying and assessing causal forces in social processes, namely: Who or what is responsible here? Where personal experiences, organizational and network dynamics, and large-scale societal forces seem to work together efficiently and without friction, the task of analyzing an organization as a singular collective instance with causal power driving a series of events is met with formidable challenges. I propose a practice-based framework on organizational agency to address such analytical issues and distinguish between three forms, namely organizational interventions, stable organizations, and competent organizational actors. Each of these three types differs in how to assess organizational agency and its constitution. To conclude, I call for a distinct sociological stance for answering questions of collective causation and responsibility in debates over legal liability in digitalized spheres and corporate or political responsibilities for large-scale social challenges, like sustainable transitions. This stance differs from Weberian roots, in that it neither preconditions formal procedures nor a collective actor. A case study of a scientific project network discovering catalytic mechanisms in producing hydrogen to drive a sustainable energy transition illustrates the analytical value of this framework.
Augmented Reality to Assist in the Diagnosis of Temporomandibular Joint Alterations
Authors: Cercenelli Laura , Emiliani Nicolas , Gulotta Chiara , Bevini Mirko , Badiali Giovanni , Marcelli Emanuela 
Published: September 2024

AbstractAugmented Reality (AR) is an increasingly prominent technology with diverse applications across various surgical disciplines. This study aims to develop and assess the feasibility of a novel AR application intended to aid surgeons in the clinical assessment of temporomandibular joint (TMJ) alterations necessitating surgical intervention. The application employs a multi-modality tracking approach, combining both marker-less and marker-based tracking techniques to concurrently track the fixed portion of the joint and the movable mandible involved in TMJ. For the marker-based tracking both a planar marker with a binary QR-code pattern and a cuboid marker that contains a unique QR-code pattern on each face were tested and compared. The AR application was implemented for the HoloLens 2 head-mounted display and validated on a healthy volunteer performing the TMJ task, i.e. the opening and closing of the mouth. During the task, video recordings from the HoloLens cameras captured the horizontal and vertical excursions of the jaw movements (TMJ movements) using virtual markers anchored to the AR-displayed virtual anatomies. For validation, the video-recorded TMJ movements during AR viewing were compared with standard kinesiographic acquisitions. The findings demonstrated the consistency between the AR-derived trajectories and the kinesiography curves, especially when using the cubic Multi Target tracker to follow the moving mandible. Finally, the AR application was experienced on a patient and it was extremely useful for the surgeon to diagnose alterations in the normal kinematics of the TMJ. Future efforts should be addressed to minimize the bulkiness of the tracker and provide additional visual cues for surgeons.
A Longitudinal Study of Aggression in People with Autism and Other Neurodevelopmental Disabilities
Authors: Gohari Dena , Schiltz Hillary , Lord Catherine 
Published: September 2024

AbstractAggression is common in autism and neurodevelopmental disorders, but longitudinal research on aggression is lacking. We longitudinally tracked aggression in 254 individuals from toddlerhood to emerging adulthood. Our sample included participants with a range of cognitive abilities, with 39.9% classified as more-cognitively-abled (MCA; IQ ≥ 70) and 60.1% as less-cognitively-abled (LCA; IQ < 70). Aggression Composite scores were derived from data from the autism diagnostic observation schedule, autism diagnostic interview-revised, and child behavior checklist at ages 2, 9, and 18. Fifty-four percent, 69%, and 42% of the sample showed aggression in toddlerhood, school age, and emerging adulthood, respectively. LCA individuals had higher rates of aggression in school age (80%) and emerging adulthood (58%) compared to MCA individuals (48 and 22%, respectively). Longitudinal aggression profiles revealed distinct patterns of change over time: 31% displayed persistent aggression, 25% increased, 23% decreased, and 13% never displayed aggression. Higher autism symptoms, lower VIQ, NVIQ, and less-developed adaptive skills correlated with more aggression cross-sectionally. Nonverbal IQ and repetitive behaviors related to aggression longitudinally: people in decreasing or absent profiles had higher NVIQ and fewer RRBs than those with persistent or increasing profiles. Participants with aggression at 9 were four times likelier to exhibit aggression at 18. Aggression is common in autism and NDDs, peaking around age 9, and declining in emerging adulthood. Patterns of change varied widely, with evidence that higher NVIQ and fewer RRBs may be protective. Findings have implications for clinical practices, highlighting important developmental periods and high-risk subgroups.
Error Estimates for First- and Second-Order Lagrange–Galerkin Moving Mesh Schemes for the One-Dimensional Convection–Diffusion Equation
Authors: Putri Kharisma Surya , Mizuochi Tatsuki , Kolbe Niklas , Notsu Hirofumi 
Published: September 2024

AbstractA new moving mesh scheme based on the Lagrange–Galerkin method for the approximation of the one-dimensional convection–diffusion equation is studied. The mesh movement is prescribed by a discretized dynamical system for the nodal points. This system is related to the velocity and diffusion coefficient in the convection–diffusion equation such that the nodal points follow the convective flow of the model. It is shown that under a restriction of the time step size the mesh movement cannot lead to an overlap of the elements and therefore an invalid mesh. Using a piecewise linear approximation, optimal error estimates in the $$\ell ^\infty (L^2) \cap \ell ^2(H_0^1)$$

ℓ
∞

(

L
2

)

∩

ℓ
2

(

H
0
1

)

norm are proved in case of both, a first-order backward Euler method and a second-order two-step method in time. These results are based on new estimates of the time dependent interpolation operator derived in this work. Preservation of the total mass is verified for both choices of the time discretization. Numerical experiments are presented that confirm the error estimates and demonstrate that the proposed moving mesh scheme can circumvent limitations that the Lagrange–Galerkin method on a fixed mesh exhibits.
Linguistic reconciliation in contexts of conflict: Tamil language learning in Sri Lanka
Authors: Perera Nirukshi , Khodos Iryna 
Published: September 2024

AbstractThis article explores how language learning is an integral component of progressing linguistic reconciliation in contexts of war and conflict. Sri Lanka is a case where ethnolinguistic division and the devaluation of Tamil as a co-official language has led to linguistic injustice for Tamil people and users of Tamil. In the post-war landscape, government commitment towards addressing this injustice, and reconciliation for that matter, has been weak. We interviewed 12 adult students and teachers in a small, non-profit, Tamil language course to understand what motivates people to learn Tamil in this context. The language course was a space where both second language and heritage language learners came together. Thematic analysis of the interview data showed that language learning motivations extended beyond the norm of the instrumental/integrative dichotomy and revealed the role of social, historical, and political factors, and a shared vision for societal multilingualism in shaping learners’ motivations. The results help to form a preliminary conceptualisation of linguistic reconciliation and to promote language learning “of the enemy” as an integral and impactful component.
Disuse atrophy of articular cartilage can be restored by mechanical reloading in mice
Authors: Nomura Masato , Moriyama Hideki , Wakimoto Yoshio , Miura Yasushi 
Published: September 2024

Abstract

Background
Moderate mechanical stress generated by normal joint loading and movements helps maintain the health of articular cartilage. Despite growing interest in the pathogenesis of cartilage degeneration caused by reduced mechanical stress, its reversibility by mechanical reloading is less understood. This study aimed to investigate the response of articular cartilage exposed to mechanical reloading after unloading in vivo and in vitro.

Methods and results
Disuse atrophy was induced in the knee joint cartilage of adult mice through hindlimb unloading by tail suspension. For in vivo experiments, mice were subjected to reloading with or without daily exercise intervention or surgical destabilization of the knee joint. Microcomputed tomography and histomorphometric analyses were performed on the harvested knee joints. Matrix loss and thinning of articular cartilage due to unloading were fully or partially restored by reloading, and exercise intervention enhanced the restoration. Subchondral bone density decreased by unloading and increased to above-normal levels by reloading. The severity of cartilage damage caused by joint instability was not different even with prior non-weight bearing. For in vitro experiments, articular chondrocytes isolated from the healthy or unloaded joints of the mice were embedded in agarose gel. After dynamic compression loading, the expression levels of anabolic (Sox9, Col2a1, and Acan) and catabolic (Mmp13 and Adamts5) factors of cartilage were analyzed. In chondrocytes isolated from the unloaded joints, similar to those from healthy joints, dynamic compression increased the expression of anabolic factors but suppressed the expression of catabolic factors.

Conclusion
The results of this study indicate that the morphological changes in articular cartilage exposed to mechanical unloading may be restored in response to mechanical reloading by shifting extracellular matrix metabolism in chondrocytes to anabolism.
Spatial patterns and effects of invasive plants on soil microbial activity and diversity along river corridors
Authors: Gömöryová Erika , Hrivnák Richard , Galvánek Dobromil , Kochjarová Judita , Skokanová Katarína , Slezák Michal , Svitková Ivana , Šingliarová Barbora , Španiel Stanislav , Gömöry Dušan 
Published: September 2024

Abstract
Background and aims
Invasive species represent a threat to the conservation of biological systems. Riparian ecosystems are vulnerable to plant invasions, as waterflow facilitates the dispersal of plant propagules, while invasive species may subsequently impact soil, including soil microbial communities. Downstream connectivity among disparate riverine segments is expected to cause spatial continuity of abiotic and biotic components of riparian ecosystems.

Methods
We studied diversity of microbial communities in three headwater streams in Central Europe. Plant diversity, soil properties and soil microbiota were assessed on 20 sample plots per river. Soil microbial activity and community-level physiological profiling were used to study the soil microbial community.

Results
While the α-diversity of plants and soil microbiota was similar among rivers, plant communities were substantially more differentiated than microbial communities. Richness in alien and invasive plants significantly differed among rivers, which was reflected in different spatial patterns of microbial activity and diversity. A high level of spatial continuity was observed in the Kysuca river with straightened riverbed and artificial surfaces in the adjacent areas. The cover of invasive plants affects the composition of microbial functional groups of riverbed soils.

Conclusion
The expectation of spatial continuity of riverbed soil properties including those of soil microbiota caused by connectivity between different river segments was only partially fulfilled. Spatial continuity strongly depends on the environmental setting and stream characteristics of a particular river. The presence of invasive herbs affected the functional composition of soil microbiota but had no effect on microbial activity and diversity.
Political Normativity… All-Things-Considered
Authors: Testini Francesco 
Published: September 2024

AbstractThe idea of a distinctively political normativity came under sustained fire lately. Here I formulate, test, and reject a moderate and promising way of conceiving it. According to this conception, political normativity is akin to the kind of normativity at play in all-things-considered judgments, i.e., those judgments that weight together all the relevant reasons to determine what practical rationality as such requires to do. I argue that even when we try to conceive political normativity in this all-things-considered way, and even when we do not concede from the get-go that moral reasons necessarily trump or override normative reasons of a different kind, political normativity is still reducible to morality, because the peculiar content of all-things-considered political oughts can be explained by the interplay of general moral principles and contextual facts that do not obtain exclusively in political scenarios. If my arguments are correct, I provide political realists with one more reason to withdraw from the metaethical battle over the idea of a distinctively political normativity and show that the moralist approach is defensible against a prima facie promising, but ultimately untenable, alternative.
Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients
Authors: Linders Daan G. J. , Bijlstra Okker D. , Fallert Laura C. , Dekker-Ensink N. Geeske , March Taryn L. , Pool Martin , Walker Ethan , Straight Brian , Basilion James P. , Bogyo Matthew , Burggraaf Jacobus , Hilling Denise E. , Vahrmeijer Alexander L. , Kuppen Peter J. K. , Crobach A. Stijn L. P. 
Published: September 2024

Abstract
Purpose
Cysteine cathepsins are proteases that play a role in normal cellular physiology and neoplastic transformation. Elevated expression and enzymatic activity of cathepsins in breast cancer (BCa) indicates their potential as a target for tumor imaging. In particular cathepsin B (CTSB), L (CTSL), and S (CTSS) are used as targets for near-infrared (NIR) fluorescence imaging (FI), a technique that allows real-time intraoperative tumor visualization and resection margin assessment. Therefore, this immunohistochemical study explores CTSB, CTSL, and CTSS expression levels in a large breast cancer patient cohort, to investigate in which BCa patients the use of cathepsin-targeted NIR FI may have added value.

Procedures
Protein expression was analyzed in tumor tissue microarrays (TMA) of BCa patients using immunohistochemistry and quantified as a total immunostaining score (TIS), ranging from 0–12. In total, the tissues of 557 BCa patients were included in the TMA.

Results
CTSB, CTSL, and CTSS were successfully scored in respectively 340, 373 and 252 tumors. All tumors showed CTSB, CTSL, and/or CTSS expression to some extent (TIS > 0). CTSB, CTSL, and CTSS expression was scored as high (TIS > 6) in respectively 28%, 80%, and 18% of tumors. In 89% of the tumors scored for all three cathepsins, the expression level of one or more of these proteases was scored as high (TIS > 6). Tumors showed significantly higher cathepsin expression levels with advancing Bloom-Richardson grade (p < 0.05). Cathepsin expression was highest in estrogen receptor (ER)-negative, human epidermal growth factor receptor 2(HER2)-positive and triple-negative (TN) tumors. There was no significant difference in cathepsin expression between tumors that were treated with neoadjuvant systemic therapy and tumors that were not.

Conclusions
The expression of at least one of the cysteine cathepsins B, L and S in all breast tumor tissues tested suggests that cathepsin-activatable imaging agents with broad reactivity for these three proteases will likely be effective in the vast majority of breast cancer patients, regardless of molecular subtype and treatment status. Patients with high grade ER-negative, HER2-positive, or TN tumors might show higher imaging signals.
Curriculare Implementierung der Profillinie Patientensicherheit in den Studiengang Humanmedizin – formative und summative Evaluationsergebnisse für den ersten und zweiten Studienabschnitt
Authors: Petzina Rainer , Heese Oliver , Marung Hartwig , Wehkamp Kai , Wulfhorst Britta , Lichtenauer Urs , Brünahl Christian 
Published: September 2024

Zusammenfassung
Hintergrund und Zielstellung
Der Masterplan Medizinstudium 2020 hat grundlegende Veränderungen in der medizinischen Ausbildung angestoßen. Nachdem das Themenfeld Patientensicherheit verstärkt in dem Nationalen Kompetenzbasierten Lernzielkatalog Medizin (NKLM) 2.0 verankert wurde und deutlich an Relevanz gewonnen hat, stellen wir den aktuellen Stand der curricularen Implementierung der Profillinie Patientensicherheit im Studiengang Humanmedizin an der MSH Medical School Hamburg (MSH) vor. Ziel ist es, zum einen darzustellen, wie die Profillinie Patientensicherheit in den Studiengang Humanmedizin an der MSH als integriertes longitudinales Curriculum implementiert wird sowie zum anderen die formativen und summativen Evaluationsergebnisse zu präsentieren.

Methode
Zunächst erfolgte eine Recherche der aktuellen Literatur, ein Screening der Homepages der medizinischen Fakultäten und darauf aufbauend ein interdisziplinärer Expert:innenaustausch. Auf dieser Grundlage wurde konsentiert die Profillinie Patientensicherheit in allen drei Studienabschnitten zu implementieren. Dies wird kontinuierlich durch die routinemäßigen Semesterbewertungen der Studierenden zur Qualitätssicherung und durch summative Prüfungen evaluiert. Zusätzlich erfolgen formative Evaluationen der Lehr‑/Lernveranstaltungen während des Semesters.

Ergebnisse
Die Ergebnisse der Literaturrecherche, des Screenings der Homepages der medizinischen Fakultäten und der Expert:innenaustausche bestätigen den zunehmenden Stellenwert von Patientensicherheit in der medizinischen Ausbildung. Daraufhin wurden die im NKLM 2.0 verankerten Kompetenzen und Lernziele zur Patientensicherheit longitudinal in den Studiengang Humanmedizin an der MSH curricular implementiert. Seit dem Sommersemester 2023 finden in den ersten beiden Studienabschnitten entsprechende Vorlesungen inklusive MC-Prüfungen, Seminare, Wahlmodule und OSCE-Prüfungen (Objective Structured Clinical Examination) zum Thema Patientensicherheit statt. Die ersten formativen und summativen Evaluationsergebnisse der Studierenden sind sehr vielversprechend und ab dem Wintersemester 2024 werden die ersten MSH-Studierenden im dritten Studienabschnitt ein Patientensicherheitssimulationstraining absolvieren.

Schlussfolgerung
Die Implementierung der Profillinie Patientensicherheit als integriertes longitudinales Curriculum in den Studiengang Humanmedizin in allen drei Studienabschnitten stellt eine große Herausforderung und dringende Erfordernis dar. Durch die Implementierung wird das für alle Querschnittsbereiche relevante Thema Patientensicherheit umfassend und nachhaltig abgebildet.
The Effect of Platelet Dose on Outcomes after Platelet Rich Plasma Injections for Musculoskeletal Conditions: A Systematic Review and Meta-Analysis
Authors: Berrigan William , Tao Frances , Kopcow Joel , Park Anna L. , Allen Isabel , Tahir Peggy , Reddy Aakash , Bailowitz Zachary 
Published: September 2024

Abstract
Purpose of Review
This study aims to systematically review platelet dosage in platelet rich plasma (PRP) injections for common musculoskeletal conditions.

Recent Findings
Notable heterogeneity exists in the literature regarding platelet dosage. Clinical studies indicate that a higher dosage may lead to improved outcomes concerning pain relief, functional improvement, and chondroprotection in knee osteoarthritis (OA). However, the impact of dosing on other musculoskeletal pathologies remains uncertain. Our investigation identifies a potential dose-response relationship between platelet dose and PRP effectiveness for knee OA treatment, pinpointing an optimal threshold of greater than 10 billion platelets for favorable clinical outcomes. Notably, this effect appears more pronounced for functional outcomes than for pain relief. For other conditions, a lower dosage may suffice, although the existing literature lacks clarity on this matter.

Summary
PRP dosage may significantly influence treatmentoutcomes, particularly in knee OA. Further research is warranted to elucidate optimal dosages for varying conditions.
Relationship between hemoglobinopathies and male infertility: a scoping review
Authors: Al-Jubouri Abdullah M. , Eliwa Ahmed , Haithm Yunes , Al-Qahtani Noof , Jolo Lolwa , Yassin Mohamed 
Published: September 2024

AbstractInfertility is a common issue that threatens couples worldwide. Infertility can result from the male or female partner alone, or both partners. It can be due to multiple factors related to the patient’s overall health or lifestyle. Causes related to patient health can be systemic or related to gonadal dysfunction. One of the systematic causes can be hematological. The two most common hemoglobinopathies that are thought to cause infertility, especially male infertility, are sickle cell disease (SCD) and thalassemia major (TM). These two hemoglobinopathies cause male infertility through pathophysiological alterations. Specifically, they alter the oxygen carrying ability of red blood cells (RBCs), causing tissue hypoxia that affects the normal physiological process of spermatogenesis, eventually inducing infertility. Semen analyses and other systemic blood testing can be used to investigate male infertility. Both hemoglobinopathies can be helped by blood transfusions, which can then alleviate male infertility. This paper aims to explore the relationship between hemoglobinopathies (SCD and TM) and their role in contributing to male infertility, in addition to the role of blood transfusions in addressing male infertility by correcting the root cause.