bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Potential Mechanism of Resveratrol in Treating Acute Kidney Injury through Network Pharmacology and Experimental Investigation
Authors: Wang Baiju , Li Han , Wang Na , Chen Hanwen , Song Zihua , Li Yuan , Chen Yajuan , Liu Lei 
Published: September 2024

Abstract

Background
Acute kidney injury (AKI) has emerged as a significant challenge in global healthcare, with incidence and mortality rates escalating annually. Resveratrol (RES), a polyphenolic compound, functions as a plant defense molecule secreted in response to environmental stimuli. RES has demonstrated broad therapeutic potential across various biological pathways. However, research on its protective effects against AKI and the underlying molecular mechanisms remains insufficient, necessitating detailed studies to elucidate its mode of action.
Methods
We utilized the GEO database and network pharmacology techniques to explore the targets of action of RES and the pathological processes of AKI. Enrichment analysis was employed to predict the involvement of key biological mechanisms. Subsequent in vitro cellular experiments were conducted to further validate the molecular mechanisms of RES.
Results
Network pharmacology and GEO data analysis identified 24 key core targets. Enrichment analysis of these targets revealed mechanisms of action between RES and AKI, primarily associated with inflammatory responses. In cellular studies, RES significantly increased the survival rate of HK-2 cells under hypoxia/reoxygenation (H/R) conditions. RT-PCR and Western blot experiments showed that, compared to the control group (Con group), the expression levels of TNF-α, IL-6, and IL-1β were upregulated, while AKT1 expression was downregulated in the H/R group. In contrast, in the RES group, expression levels of TNF-α, IL-6, and IL-1β were significantly reduced compared to the H/R group, while AKT1 expression was upregulated.
Conclusion
Through network pharmacology and GEO analysis, we identified multiple targets implicated in RES's mechanism of action on AKI. Specifically, RES modulates AKT1 and various pro-inflammatory cytokines, thereby manifesting its protective effects against AKI.
Exploring the effect of differing centre hydration and anti-emetic policies on acute gastrointestinal and renal toxicities in the De- ESCALaTE trial
Authors: Kong Anthony , Hazell Matthew , Iqbal Gulnaz , Dunn Janet , Mehanna Hisham 
Published: September 2024

Abstract

Background
The De-ESCALaTE trial confirmed the superiority of cisplatin over cetuximab in combination with radiotherapy for the treatment of low risk HPV + oropharyngeal cancer (HPV + OPC). However, there were concerns about certain toxicities with the use of cisplatin, in particular nausea, vomiting, dehydration and renal toxicities.
Methods
The De-ESCALaTE trial collected data on several centre level policies on hydration and anti-emetic use. Univariable and backwards stepwise multivariable logistic regression models were used to model the association between centre level policy variables and severe adverse events (SAEs) of interest and severe (grade 3–5) acute toxicities of interest. In addition, the predictive performance of each model was assessed.
Results
Centre level policies including the use of a triple anti-emetics regimen pre and post chemotherapy, increased volumes of IV fluids given before and during cisplatin chemotherapy as well as oral fluids advised post chemotherapy, were all associated with a reduced odds of SAEs of interest. Only a policy to give diuretics was associated with a reduction of severe (grade 3–5) acute toxicities of interest.
Conclusions
For centres with HPV + OPC patients undergoing chemoradiation, we recommend the use of specific hydration and anti-emetic policies to reduce the rates of relevant SAEs and severe acute toxicities.
The study on water supply and demand matching and flow in Upper Hanjiang River basin basin of China
Authors: Ma Xinping , Li Jing , Yu Yuyang 
Published: September 2024

Abstract

Water supply service flow is an important link between natural ecosystem and human society, and has great significance for the production, transfer and consumption of water supply service. Taking the upper Hanjiang River basin in Shaanxi Province as an example, SWAT model and GIS were used to simulate the spatial flow process of water supply services and water demand at different spatial-temporal scales, and the spatial scope and service flow of typical supply and benefit areas of the basin were defined. The results show that the water supply in the basin is obviously higher than the water demand, and the water supply and demand level of most administrative units is higher. However, with the change of time, the water supply and demand level in the basin gradually formed extreme characteristics. In terms of discharge, the direction of water supply and demand is consistent with the characteristics of topography, and the discharge and flow momentum at the sub-basin scale show a decreasing trend. The results can provide reference for water resources protection and water quantity monitoring in the basin.
The Management of nurses in Internet-based home care in tertiary general hospitals in China: Mixed Methods Study
Authors: Cao Ziwei , Yue Liqing , Peng Huan , Li Bingyu , Peng Bin 
Published: September 2024

Abstract

Background
China is currently implementing a “Internet-Based Home Care” program that refers to medical institutions use institution-registered nurses to provide door-to-door nursing services to patients discharged from hospitals/illnesses with limited mobility through an "online application and offline service" model. And tertiary general hospitals are playing a leading role in this program.The management of nurses in the program is crucial. But the overall development situation of Internet-based home care in tertiary general hospitals is still unclear.
Purpose:
To understand the current situation and problems in the management of nurses' participation in Internet-based home care in tertiary general hospitals in China, and to propose corresponding recommendations and strategies.
Methods:
From March 1 to December 31, 2022, a two-stage mixed method approach was used in this study. Phase 1 employed an online survey to explore the current situation and problems in the management of nurses' participation in Internet-based home care in Chinese tertiary general hospitals. Based on the findings of phase 1, phase 2 included a focus group interview to collect nurses' views and opinions on the program.
Results:
The survey results showed that the coverage of Internet-based home care in Chinese tertiary general hospitals was 64.1%. According to the survey results of these hospitals that had carried out Internet-based home care, 51.3% of these hospitals had less than 5% of all nurses participating in the program. And 85% of the 75 hospitals provided this service less than 50 times per month. 97.33% of the 75 hospitals provided pre-job training and assessment for nurses who participated in the program, but there were no uniform training and assessment standards. And there still were legal risks and medical safety risks in this program. The mechanisms for distributing benefits among the involved parties have not yet been well established. In addition, a total of 3 main themes were identified in the interviews, including (1) attitudes of nurses, (2) proposals, and (3) expectations and supports.
Conclusion:
This study investigated the current situation of nurses' participation in Internet-based home care services in tertiary general hospitals in China. Meanwhile, it explored the problems and recommendations related to human resources, safety assurance, training and assessment, performance, and incentive mechanisms for nurses participating in the program. It is suggested that relevant departments in China should learn from the mature experience of home care abroad, combine it with the actual situation in China, explore the training system, formulate implementation rules, clarify the process, and guide the standardized development of Internet-based home care.
The mediating role of professional values and self-efficacy in the relationship between organizational justice and quality of working life among nurses in southwestern Iran
Authors: Ansari Sahar , Mohebbi Zinat , Torabizadeh Camellia 
Published: September 2024

Abstract

Background: An optimal quality of working life (QWL) is crucial for the preservation and maintenance of employees. Organizational justice, as a significant organizational factor, leads to the improvement and enhancement of QWL in organizations, which can in turn promote organizational commitment, job satisfaction, and ultimately increased productivity. One variable that can be influenced by organizational justice is self-efficacy, which strengthens the flexibility of nurses in challenging operating room environments. Professional values form the foundation of the nursing profession, enabling nurses to manage conflicts and prioritize actions. The purpose of this study was to determine the relationship between organizational justice and quality of work life, with an emphasis on the mediating role of professional values and self-efficacy among the operating room and anesthesia nurses.
Methods: This cross-sectional study was conducted in Iran in 2023.Via convenience sampling, 376 operating room and anesthesia nurses participated in this study. Data were collected in person using five questionnaires: demographic characteristics, organizational justice (Niehoff & Moorman), quality of work life (Walton), professional values (Schank & Weis), and job self-efficacy (Riggs).
Results: 376 operating room and anesthesia nurses with a mean age of 33.92 ± 7.02 years and a mean work experience of 9.98 ± 7.76 years participated in the study. The majority were female (60.6%). According to the results of structural equation modeling, the mediating variables of professional values (T-values = 7.11) and self-efficacy (T-values = 4.46) had a statistically significant effect on the correlation between organizational justice and nurses' QWL. The results of the Sobel test and Variance Accounted For (VAF) statistics also confirmed the mediating role of professional values and self-efficacy in the relationship between organizational justice and QWL.
Conclusion: Organizational justice not only directly impacts QWL but also indirectly affects it through professional values and self-efficacy. Policymakers in the healthcare system and hospital managers can enhance QWL and promote a fairer work environment in operating rooms by increasing their self-efficacy levels and respecting nursing professional values.
Factors Influencing the Choices of Coffee Marketing Channels by Smallholder Farmers in Jimma Zone, Oromia Region, Southwestern Ethiopia
Authors: Asmare Zewdu Getachew , Kenee Fekadu Beyene , Mohamed Jema Haji , Tefera Tesfaye Lemma 
Published: September 2024

Abstract

Coffee is one of the most important agricultural commodities with significant contributions to the growth and well-functioning of Ethiopia’s economy, and the social stability of the country (Alemseged, 2012). Despite its importance, the performance of the sector has been unsatisfactory due to various production- and marketing-related factors. This study was thus conducted with the objective of identifying the factors influencing the choices of marketing channels for selling dry-processed or red coffee cherries. Cross-sectional survey data were collected from 377 sample farmers selected from Gomma and Limmu Kossa districts of Jimma zone in southwestern Ethiopia through a multistage stratified simple random sampling technique. The data were collected from October 2019 to January 2020 after pretesting the questionnaire. Descriptive statistics and a multivariate probit (MVP) econometric model were used to analyse the data. The results obtained from separate MVP regression model analyses reveal that sex, coffee land size and productivity, average dry-processed coffee selling price, frequency of visits by the DA, cooperative membership, access to credit, training, off- and non-farm income sources, and distance to cooperatives’ and private traders’ marketing centers influenced the choices of local consumers, traders or cooperatives for selling dry-processed or red coffee cherries. The findings suggest that farmers should be provided with coffee production- and productivity-enhancing technologies that could increase yield and productivity and the marketed supply of coffee. Moreover, farmers should be provided with information regarding the importance of cooperatives and training on ways to improve coffee production and productivity. Finally, cooperatives should incorporate credit schemes at peak coffee production and during the marketing season so that members prefer to supply their coffee to the cooperatives and earn better coffee income at the end.
Evaluation of Novel and Traditional Anthropometric Indices for Predicting Metabolic Syndrome and Its Components: A Cross-Sectional Study of the Nepali Adult Population
Authors: Pokharel Daya Ram , Maskey Abhishek , Kafle Ramchandra , Kathayat Goma , Manandhar Binod , Manandhar Krishna Das 
Published: September 2024

Abstract

Background
Various anthropometric indices have been proposed to assess central obesity and predict metabolic syndrome (MetS). However, their predictive capabilities for MetS have not been evaluated in the Nepali adult population. This study aimed to compare the predictive potential of 12 anthropometric indices for MetS and its components among Nepali adults.
Methods
Baseline data were collected from 1116 adult residents (424 females, 792 males) of Gandaki Province, Nepal aged between 30–86 years. Twelve anthropometric indices viz. Body Mass Index (BMI), Waist-Hip Ratio (WHR), Waist-Height Ratio (WHtR), Weight-Adjusted-Waist Index (WWI) A Body Shape Index (ABSI), Abdominal Volume Index (AVI), Body Adiposity Index (BAI), Body Roundness Index (BRI), Clinica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE), Conicity Index (CI), Lipid Accumulation Product (LAP), Visceral Adiposity Index (VAI) were calculated. MetS was defined using modified National Cholesterol Education Program (NCEP) Adult Treatment Panel III (NCEP-ATP III) criteria. Receiver operating characteristic curve analysis was carried out to determine the predictive ability (AUCs, optimal cut-offs, Youden indices, sensitivities, and specificities) of these indices for MetS and its components. AUC differences between various index pairs were also calculated.
Results
VAI demonstrated the best performance in predicting MetS (AUC: 0.866 for females, 0.882 for males), followed by LAP (AUC: 0.839 for females, 0.869 for males). WHR showed good performance (AUC: 0.749 for females, 0.722 for males). WHtR and BRI performed similarly (AUCs: 0.687–0.697). Optimal cutoffs were as follows: VAI > 1.97 (females), > 2.16 (males); LAP > 53.4 (both sexes); WHR > 0.98 (both sexes); WHtR > 0.638 (females), > 0.56 (males); BRI > 5.76 (females), > 4.75 (males). ABSI and BAI exhibited the poorest diagnostic performance for MetS prediction in both sexes (AUC < 0.530).
Conclusion
Among Nepali adults, VAI and LAP outperformed traditional measures such as BMI, WHR and WHtR in predicting MetS and its components. These findings contribute to developing population-specific screening strategies for MetS in Nepal, potentially enhancing early detection and prevention of cardiometabolic disorders.
Proximate and mineral compositions of rice varieties from three (3) agro ecological zones in Nigeria
Authors: Enyi Chukwunwike Uchenna , Nwachukwu Chinwe Adaobi , Ogbedeagu Clara Obiageri , Okorie-Humphrey Chinasa 
Published: September 2024

Abstract

This study aims to evaluate the proximate and mineral compositions of rice varieties from three agro ecological zones in Nigeria. Kano. Rice varieties: Faros 44, 52 and 60 were purchased directly from the Agricultural development centers from these ecological zones, and subjected to evaluation of proximate and mineral compositions. The research findings indicate that moisture contents ranged from 10.80 (Faro 52 from Kano) to 13.33% (Faros 44, 52 and 60 from Ebonyi). Low fat content was observed in Faro 44 from Niger (0.28%) while Faros 52 from Ebonyi recorded the highest fat content of 0.65%. Protein ranged from 10.4% (Faro 44 from Ebonyi) to 15.9% (Faro 44 from Kano); ash from 0.66% (Faro 52 from Ebonyi) to 2.04% (faro 44 and 60 from Ebonyi and faro 60 from Niger); fiber from 0.7% (Faro 44 from Kano) to 5.5% (Faro 60 from Ebonyi); carbohydrate from 64.12 (Faro 60 from Ebonyi) to 73.07% (Faro 52 from Niger). Calcium ranged from 1.04 to 1.87 mg/100g. Faro 60 from Ebonyi recorded the highest while Faro 52 from Niger recorded the lowest. Zinc ranged from 1.24 to 3.88 mg/100g. Faro 44 from Ebonyi recorded the highest while Faro 44 from Kano recorded the lowest. Magnesium ranged from 0.008 to 0.26 mg/100g. Faro 44 from Niger recorded the highest while Faro 60 from Ebonyi recorded the lowest. Analysis of variance revealed that zone, variety, and interactive effect of zone and variety, had significant (P < 0.05) effect on the proximate and mineral compositions of the parameters evaluated.
Characterization of the complete genome of a novel allexivirus infecting Sauropus androgynus in China
Authors: Zhu Li-Juan , Su Lan-Yi , Sen Xing , Pan Shifang , Xia Fagang , Han Yan-Hong , Xu Zhongtian , Xu Qian 
Published: September 2024

Abstract

A new virus was found in S. androgynus with curled and yellow leaves in China, andtentatively named as sauropus androgynus virus(SaV). The complete genome of SaV is an 8,007 nucleotides (+) single-stranded RNA excluding a 3’-poly(A) tail, and contains six open reading frames (ORFs). Both pairwise comparisons and phylogenetic analyseswith putative replicase or coat protein show that SaV shares high homology with allexiviruses in the family Alphaflexiviridae. SaV should be the first allexivirus reported in S. androgynus.
Postgraduate GPs’ experience of attending Medical Uncertainty Training during the Standardised Training of Residents: A qualitative process evaluation
Authors: Liu Zhihui , Zhao Yingshuai , Shi Weili , Wang Liuyi 
Published: September 2024

Abstract

Background
Uncertainty is a pervasive aspect of primary healthcare, significantly impacting clinical decision-making and patient outcomes. Medical Uncertainty Training (MUT) courses aim to equip healthcare providers with the skills needed to manage this uncertainty effectively.
Objective
To explore post-graduate General Practitioners' (GPs) experiences and perspectives on attending MUT courses during standardized residency training in China, focusing on the potential mechanism of such courses in handling uncertainty and identified areas for improvement.
Methods
A qualitative study utilizing semi-structured interviews was conducted with 15 post-graduate GPs, selected through purposive sampling from January 2024 to March 2024. Data were collected through in-depth interviews conducted face-to-face or via video conferencing, transcribed verbatim, and analyzed using NVivo14 software. Themes related to the course's structure, process, and outcomes were identified.
Results
Three principal themes emerged from the process evaluation interviews, categorized according to the Donabedian structure-process-outcome framework as teaching structure, teaching process, and teaching outcome. These themes were further subdivided into specific sub-themes including necessity of the course, comprehensive curriculum design, cognitive, emotional and behavioral education, flexibility and accessibility, interactive learning methods, continuous feedback and reflection, enhanced clinical judgment, increased resilience and confidence, Real-World application challenges.
Conclusion
The process evaluation findings provided more information on GPs' perceptions and experiences of attending MUT. Compared to increasing tolerance for uncertainty, medical students are more concerned with improving their personal competence in uncertain situations. By integrating cognitive, emotional, and behavioral education, the course builds GPs' confidence and skills in handling complex medical cases. Future research should validate these results across diverse settings and assess the long-term impact on clinical practice and professional development.
Low knowledge levels and high willingness to use oral Pre-Exposure Prophylaxis (PrEP) among Key Populations in Kampala, Uganda: Implications for targeted educational interventions
Authors: Ssuna Bashir , Armstrong-Hough Mari , Ngaybe Maiya G Block , Kalibbala Dennis , Kalyango Joan N , Kiweewa Flavia Matovu 
Published: September 2024

Abstract

Background: Preexposure prophylaxis (PrEP) reduces new human immunodeficiency virus(HIV) infections by up to 96% and is recommended for key populations by the World Health Organization. Understanding the knowledge and willingness to use PrEP is essential for effective implementation. This study assessed these factors and identifiedcharacteristics associated with differences in knowledge among key populations in Kampala, Uganda.
Methods: We administered a cross-sectional survey to a systematic sample of 497 participants from fisherfolk (283, 56.9%), men who have sex with men (MSM) (93, 18.7%), and female sex worker (FSW) (121, 24.4%) communities in Kampala Central, where PrEP had not yet been rolled out. Data on sociodemographic characteristics, PrEP awareness, and HIV-related behavioralfactors were collected. Knowledge about PrEP was measured using an adopted questionnaire comprising five key questions about PrEP knowledge, graded as no knowledge, some knowledge and good knowledge. Ordered probit regression models were used to analyze the associations of independent factors with PrEP knowledge levels.
Results: Participants had a mean age of 29±7.6 years. Ofthese, 257 (51.7%) reported having sex with women, 157 (31.6%) with men and 83 (16.7%) with both men and women. Self-reported HIV-positive status was 6.4% in fisherfolk, 11.8% in MSM and 27.3% in FSW. PrEP awareness stood at 62.4% overall, with the highest awareness in FSW (73.6%) and the lowest in fisherfolk (54.1%). Willingness to use PrEP was high across all groups (77.7%), although it was lower among FSW (66.9%). Multivariate probit analysis highlighted key independent factors associated with PrEP knowledge among fisherfolks and HIV-related concerns (Adj. Coeff = 0.54, 95% CI: 0.11, 0.97) and lack of PrEP awareness (Adj. Coeff = -0.99, 95% CI:-1.28, -0.70); among MSM, lack of PrEP awareness (Adj. Coeff = -1.74, 95% CI:-2.38, -1.10); and in FSW, tertiary education (Adj. Coeff = 1.53, 95% CI: 0.07, 2.99) and marital status (Adj. Coeff = 0.57, 95% CI=0.09, 1.05). MEshighlighted the influence of these independent factors at each knowledge level.
Conclusions and Recommendations: Despite the high willingness to use PrEP, significant knowledge gaps exist, particularly concerning dosage and use duration, which are influenced by factors such as HIV concern and educational attainment. Tailored educational initiatives may bridge these gaps and enhance willingness to use PrEP.