bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new diapsid from the Middle Triassic of southern China
Authors: Li Chun , Fraser Nicholas C. , Rieppel Olivier , Zhao Li-Jun , Wang Li-Ting 
Published: April 2017

AbstractThe Middle and early Late Triassic of southern China is well known for a remarkable diversity of marine vertebrates, particularly reptiles, including an abundance of intriguing new forms (e.g., Jiang et al., 2005; Hu et al., 2011; Li et al., 2016). Here we describe a new diapsid from Yunnan Province. It possesses an elongate neck that exhibits a remarkable similarity to that of many Protorosauria, yet in other respects the skull and postcranium are much less derived.The new taxon is part of the so-called Panxian-Luoping Fauna and the deposits correspond to the Upper Member of the Guanling Formation, comprising thin to medium bedded, gray to dark-gray laminated marly limestone and limestone, with several layers of bentonite intercalated in the fossil level at Panxian (Wan, 2002; Motani et al., 2008; Jiang et al., 2009). Their age is Pelsonian (middle Anisian, Middle Triassic) as is indicated by the conodont Nicoraella kockeli Zone (Sun et al., 2006; Zhang et al., 2009). A recent U-Pb study indicates the absolute age of these middle Anisian beds to be close to 244 Ma (Wang et al., 2014).
REGULATING EXCESSIVE SPECULATION: COMMODITY DERIVATIVES AND THE GLOBAL FOOD CRISIS
Authors: Chadwick Anna 
Published: April 2017

AbstractEvidence suggests that commodity derivatives speculation contributed to extraordinary patterns of grain price volatility that led to a global food crisis in 2007–11. People in countries throughout the world are increasingly dependent on international commodity markets for access to food. Almost everywhere, now, the value of food is determined by a single condensed symbol of its worth—its price. Persuaded of the need to ensure that this measure of value is not put at risk of distortion in the pursuit of financial profit, governments in the US and in the EU are now implementing new regulations designed to curb ‘excessive’ levels of speculation in derivative markets. Carrying out an analysis of these regulatory measures, the article demonstrates that both sets of reforms suffer from a critical limitation: They are predicated on an inaccurate understanding of how activity in commodity derivative markets can impact on underlying food prices. If the new regulations for commodity derivative markets are not up to the task, as this article argues that they are not, a more fundamental revision of global economic structures may be required if the basic needs of human beings are not to be subsumed to the interests of financial capital in the years to come.
Selective attention and mismatch negativity in antipsychotic-naïve, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy
Authors: Oranje B. , Aggernaes B. , Rasmussen H. , Ebdrup B. H. , Glenthøj B. Y. 
Published: April 2017

BackgroundAttention deficits have been frequently reported in schizophrenia. It has been suggested that treatment with second-generation antipsychotics can ameliorate these deficits. In this study, the influence of 6 months treatment with quetiapine, a compound with less affinity for dopamine D2 receptors than for serotonergic 5-HT2A receptors, on electrophysiological parameters of attention was investigated in a group of antipsychotic-naïve, first-episode schizophrenia patients compared with a group of age- and gender-matched healthy controls.MethodA total of 34 first-episode, antipsychotic-naïve patients with schizophrenia and an equal number of healthy controls were tested in a selective attention and a typical mismatch negativity (MMN) paradigm at baseline and after 6 months. The patients were treated with quetiapine according to their clinical needs during the period between baseline and follow-up, whereas controls received no treatment.ResultsPatients showed lower MMN and P200 amplitude than healthy controls in the selective attention paradigm at baseline, while this was not the case for MMN of the typical MMN paradigm. Interestingly, after 6 months treatment, this MMN deficit was only ameliorated in patients treated with above median dosages of quetiapine. Patients had lower P3B amplitude, yet showed similar levels of processing negativity and N100 amplitude compared with healthy controls, both at baseline and follow-up.ConclusionsThe results indicate that deficits in MMN, P200 and P3B amplitude are present at early stages of schizophrenia, although depending on the paradigm used. Furthermore, the results indicate that 6 months quetiapine treatment ameliorates MMN but not P3B deficits, and only in those subjects on higher dosages.
Childhood adversity, adult stress, and the risk of major depression or generalized anxiety disorder in US soldiers: a test of the stress sensitization hypothesis
Authors: Bandoli G. , Campbell-Sills L. , Kessler R. C. , Heeringa S. G. , Nock M. K. , Rosellini A. J. , Sampson N. A. , Schoenbaum M. , Ursano R. J. , Stein M. B. 
Published: April 2017

BackgroundThe stress sensitization theory hypothesizes that individuals exposed to childhood adversity will be more vulnerable to mental disorders from proximal stressors. We aimed to test this theory with respect to risk of 30-day major depressive episode (MDE) and generalized anxiety disorder (GAD) among new US Army soldiers.MethodsThe sample consisted of 30 436 new soldier recruits in the Army Study to Assess Risk and Resilience (Army STARRS). Generalized linear models were constructed, and additive interactions between childhood maltreatment profiles and level of 12-month stressful experiences on the risk of 30-day MDE and GAD were analyzed.ResultsStress sensitization was observed in models of past 30-day MDE (χ28 = 17.6, p = 0.025) and GAD (χ28 = 26.8, p = 0.001). This sensitization only occurred at high (3+) levels of reported 12-month stressful experiences. In pairwise comparisons for the risk of 30-day MDE, the risk difference between 3+ stressful experiences and no stressful experiences was significantly greater for all maltreatment profiles relative to No Maltreatment. Similar results were found with the risk for 30-day GAD with the exception of the risk difference for Episodic Emotional and Sexual Abuse, which did not differ statistically from No Maltreatment.ConclusionsNew soldiers are at an increased risk of 30-day MDE or GAD following recent stressful experiences if they were exposed to childhood maltreatment. Particularly in the military with an abundance of unique stressors, attempts to identify this population and improve stress management may be useful in the effort to reduce the risk of mental disorders.
Detecting Clusters in Atom Probe Data with Gaussian Mixture Models
Authors: Zelenty Jennifer , Dahl Andrew , Hyde Jonathan , Smith George D. W. , Moody Michael P. 
Published: April 2017

AbstractAccurately identifying and extracting clusters from atom probe tomography (APT) reconstructions is extremely challenging, yet critical to many applications. Currently, the most prevalent approach to detect clusters is the maximum separation method, a heuristic that relies heavily upon parameters manually chosen by the user. In this work, a new clustering algorithm, Gaussian mixture model Expectation Maximization Algorithm (GEMA), was developed. GEMA utilizes a Gaussian mixture model to probabilistically distinguish clusters from random fluctuations in the matrix. This machine learning approach maximizes the data likelihood via expectation maximization: given atomic positions, the algorithm learns the position, size, and width of each cluster. A key advantage of GEMA is that atoms are probabilistically assigned to clusters, thus reflecting scientifically meaningful uncertainty regarding atoms located near precipitate/matrix interfaces. GEMA outperforms the maximum separation method in cluster detection accuracy when applied to several realistically simulated data sets. Lastly, GEMA was successfully applied to real APT data.
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
Authors: Xie Feng , Jin Ke , Shao Li , Fan Yao , Tu Yifei , Li Yihao , Yang Bin , van Dam Hans , ten Dijke Peter , Weng Honglei , Dooley Steven , Wang Shuai , Jia Junling , Jin Jin , Zhou Fangfang , Zhang Long 
Published: April 2017

AbstractTGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-β response. Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts the FAF1–VCP complex and reduces FAF1 at the plasma membrane. The latter results in an increase in TβRII at the cell surface that promotes both TGF-β-induced SMAD and non-SMAD signalling. We uncover a metastasis suppressing role for FAF1 through analyses of FAF1-knockout animals, various in vitro and in vivo models of epithelial-to-mesenchymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progression and clinical breast cancer samples. These findings describe a previously uncharacterized mechanism by which TβRII is tightly controlled. Together, we reveal how SMAD and AKT pathways interact to confer pro-oncogenic responses to TGF-β.
Nanodiamond-enhanced MRI via in situ hyperpolarization
Authors: Waddington David E. J. , Sarracanie Mathieu , Zhang Huiliang , Salameh Najat , Glenn David R. , Rej Ewa , Gaebel Torsten , Boele Thomas , Walsworth Ronald L. , Reilly David J. , Rosen Matthew S. 
Published: April 2017

AbstractNanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton–electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.
Functional organization of protein determinants of meiotic DNA break hotspots
Authors: Ma Lijuan , Fowler Kyle R. , Martín-Castellanos Cristina , Smith Gerald R. 
Published: April 2017

AbstractDuring Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linear elements (LinEs) analogous to the axial elements of the synaptonemal complex (SC) in other organisms. LinE proteins also promote the formation of meiotic DNA double-strand breaks (DSBs), the precursors of cross-overs. Rec10 is required for essentially all DSBs and recombination, and three others (Rec25, Rec27, and Mug20) are protein determinants of DSB hotspots – they bind DSB hotspots with high specificity and are required for DSB formation there. These four LinE proteins co-localize in the nucleus in an interdependent way, suggesting they form a complex. We used random mutagenesis to uncover recombination-deficient missense mutants with novel properties. Some missense mutations changed essential residues conserved among Schizosaccharomyces species. DSB formation, gene conversion, and crossing-over were coordinately reduced in the mutants tested. Based on our mutant analysis, we revised the rec27 open reading frame: the new start codon is in the previously annotated first intron. Genetic and fluorescence-microscopy assays indicated that the Rec10 N- and C-terminal regions have complex interactions with Rec25. These mutants are a valuable resource to elucidate further how LinE proteins and the related SCs of other species regulate meiotic DSB formation to form crossovers crucial for meiosis.
Efficient High-Power Ultrashort Pulse Compression in Self-Defocusing Bulk Media
Authors: Seidel Marcus , Brons Jonathan , Arisholm Gunnar , Fritsch Kilian , Pervak Vladimir , Pronin Oleg 
Published: April 2017

AbstractPeak and average power scalability is the key feature of advancing femtosecond laser technology. Today, near-infrared light sources are capable of providing hundreds of Watts of average power. These sources, however, scarcely deliver pulses shorter than 100 fs which are, for instance, highly beneficial for frequency conversion to the extreme ultraviolet or to the mid- infrared. Therefore, the development of power scalable pulse compression schemes is still an ongoing quest. This article presents the compression of 90 W average power, 190 fs pulses to 70 W, 30 fs. An increase in peak power from 18 MW to 60 MW is achieved. The compression scheme is based on cascaded phase-mismatched quadratic nonlinearities in BBO crystals. In addition to the experimental results, simulations are presented which compare spatially resolved spectra of pulses spectrally broadened in self-focusing and self-defocusing media, respectively. It is demonstrated that balancing self- defocusing and Gaussian beam convergence results in an efficient, power-scalable spectral broadening mechanism in bulk material.
Lineage-specific SNPs for genotyping of Mycobacterium tuberculosis clinical isolates
Authors: Dou Horng-Yunn , Lin Chien-Hsing , Chen Yih-Yuan , Yang Shiu-Ju , Chang Jia-Ru , Wu Keh-Ming , Chen Ying-Tsong , Chin Pei-Ju , Liu Yen-Ming , Su Ih-Jen , Tsai Shih-Feng 
Published: April 2017

AbstractTuberculosis (TB) is a severe infectious disease worldwide. Genetic variation of the causative agent, Mycobacterium tuberculosis (MTB), determines the outcomes of infection and anti-TB treatment. Until recently, there has been no effective and convenient way for classifying clinical isolates based on the DNA sequences of the divergent lineages of MTB infecting human populations. Here, we identified single nucleotide polymorphisms (SNPs) of six representative strains from Taiwan by whole-genome sequencing and comparing the results to the sequence of the H37Rv reference strain. One hundred and ten SNPs, each unique to one of the six strains, were used to genotype 150 additional isolates by applying DNA mass spectrometry. Lineage-specific SNPs were identified that could distinguish the major lineages of the clinical isolates. A subset including 32 SNPs was found to be sufficient to type four major groups of MTB isolates in Taiwan (ancient Beijing, modern Beijing, East African–Indian, and Latin-American Mediterranean). However, there was high genetic homozygosity within the Euro-American lineage, which included spoligotype-classified Haarlem and T strains. By whole-genome sequencing of 12 representative Euro-American isolates, we identified multiple subtype-specific SNPs which allowed us to distinguish two major branches within the Euro-American lineage.
Risk of infections in patients with gout: a population-based cohort study
Authors: Spaetgens B. , de Vries F. , Driessen J. H. M. , Leufkens H. G. , Souverein P. C. , Boonen A. , van der Meer J. W. M. , Joosten L. A. B. 
Published: April 2017

AbstractTo investigate the risk of various types of infections (pneumonia and urinary tract infection (UTI)), and infection-related mortality in patients with gout compared with population-based controls. A retrospective cohort study was conducted using data from the UK Clinical Practice Research Datalink (CPRD). All patients with a first diagnosis of gout and aged >40 years between January 1987-July 2014, were included and matched with up to two controls. Time-varying Cox proportional hazards models were used to estimate the risk of infections and mortality. 131,565 patients and 252,763 controls (mean age: 64 years, 74% males, mean follow-up of 6.7 years) were included in the full cohort. After full statistical adjustment, the risk of pneumonia was increased (adj. HR 1.27, 95% CI 1.18 to 1.36), while the risk of UTI (adj. HR 0.99, 95% CI 0.97 to 1.01) was similar in patients compared to controls. No differences between patients and controls were observed for infection-related mortality due to pneumonia (adj. HR 1.03, 95% CI 0.93 to 1.14) or UTI (adj. HR 1.16, 95% CI 0.98 to 1.37). In conclusion, patients with gout did not have decreased risks of pneumonia, UTI or infection-related mortality compared to population-based controls.
Using Chironomus dilutus to identify toxicants and evaluate the ecotoxicity of sediments in the Haihe River Basin
Authors: Zhu Xiaolei , Shan Baoqing , Tang Wenzhong , Zhang Chao 
Published: April 2017

AbstractTo effectively manage a watershed and successfully restore a river system, it is very important to assess the toxicity of sediments and identify the substances causing the toxicity. Seventy-six sediments collected in the Haihe River Basin (HRB) in China were screened for acute toxicity using Chironomus dilutus. We found that sediments from more than 32% of sampling sites, distributed mainly in the Ziya tributary and along the estuary, were acutely toxic to midges. A toxicity identification evaluation showed that the toxicity of the sediment samples was mainly from ammonia nitrogen, metals, and organics. Calculations of the toxic unit (TU) showed that ammonia and metals contributed more to sediment toxicity than organics, and that PAHs may have contributed in other tributaries. A modified three-step sequential extraction procedure to assess the bioavailability of the metals indicated that the toxicity from metals was mainly from Cd and Zn. This is one of the first studies in which this type of approach has been applied to directly connect contaminants with ecological effects in the HRB.
Forbs enhance productivity of unfertilised grass-clover leys and support low-carbon bioenergy
Authors: Cong Wen-Feng , Jing Jingying , Rasmussen Jim , Søegaard Karen , Eriksen Jørgen 
Published: April 2017

AbstractIntensively managed grasslands are dominated by highly productive grass-clover mixtures. Increasing crop diversity by inclusion of competitive forbs may enhance biomass production and sustainable biofuel production. Here we examined if one or all of three forbs (chicory, Cichorium intybus L.; caraway, Carum carvi L.; plantain, Plantago lanceolata L.) included in ryegrass-red clover mixtures enhanced above- and below-ground productivity, and assessed their biofuel potentials, based on a three-year experiment with and without fertilisation as cattle slurry. We determined herbage yield, standing root biomass, and estimated methane energy output and greenhouse gas (GHG) emissions per energy unit using life cycle assessment. Results showed that plantain-containing grass-clover mixtures significantly increased herbage yield, while chicory- or caraway-containing mixtures maintained similar yields to the grass-clover mixture. Standing root biomass of the grass-clover mixture was enhanced by inclusion of caraway and plantain, with that of plantain further enhanced by fertilisation. The highest methane energy output was achieved in plantain-containing grass-clover mixtures. All unfertilised mixtures achieved the 60% reduction in GHG emissions compared to fossil fuel, whereas all fertilised mixtures did not meet the 60% reduction target. These findings suggest that including competitive forbs such as plantain in grass-clover mixtures enhances productivity, supporting low-carbon footprint bioenergy production.
Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque in human coronary artery at 16 frames per second
Authors: Hui Jie , Cao Yingchun , Zhang Yi , Kole Ayeeshik , Wang Pu , Yu Guangli , Eakins Gregory , Sturek Michael , Chen Weibiao , Cheng Ji-Xin 
Published: April 2017

AbstractIntravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipid-laden plaques, as it provides simultaneous morphological and lipid-specific chemical information of an artery wall. Real-time imaging and display at video-rate speed are critical for clinical utility of the IVPA-US imaging technology. Here, we demonstrate a portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging speed was achieved by concurrent innovations in excitation laser source, rotary joint assembly, 1 mm IVPA-US catheter size, differentiated A-line strategy, and real-time image processing and display algorithms. Spatial resolution, chemical specificity, and capability for imaging highly dynamic objects were evaluated by phantoms to characterize system performance. An imaging speed of 16 frames per second was determined to be adequate to suppress motion artifacts from cardiac pulsation for in vivo applications. The translational capability of this system for the detection of lipid-laden plaques was validated by ex vivo imaging of an atherosclerotic human coronary artery at 16 frames per second, which showed strong correlation to gold-standard histopathology. Thus, this high-speed IVPA-US imaging system presents significant advances in the translational intravascular and other endoscopic applications.
The Influence of Social Support and Coping on Quality of Life Among Elderly With Age-Related Hearing Loss
Authors: Moser Sarah , Luxenberger Wolfgang , Freidl Wolfgang 
Published: April 2017

Purpose
The consequences of hearing loss hinder the everyday life of older adults and are associated with reduced well-being. The research aim was to explore the influence of hearing problems, various coping strategies, and perceived social support on quality of life.

Method
Sixty-five older adults with age-related hearing loss (≥55 years) in Austria participated and completed a paper–pencil survey with standardized questionnaires: Hearing Handicap Inventory for the Elderly (Ventry and Weinstein, 1982), Assessment for Coping and Stress (Laireiter, 1997), short form of the Social Support Questionnaire (Fydrich, Sommer, Tydecks, & Brähler, 2009), and World Health Organization Quality of Life Scale–Brief Version (World Health Organization, 1996).

Results
Quality of life was predicted by perceived social support and the number of comorbid diseases (i.e., the physical, psychological, environmental, and social quality of life was better the greater the extent of perceived social support and poorer the more diseases from which the participants suffered).

Conclusions
Perceived social support may be a relevant factor to focus on in auditory rehabilitation programs, in particular, for participants who communicate little support in hearing-related situations and are, hence, at a relative disadvantage. The involvement of significant others in counseling could facilitate the everyday life for older adults with age-related hearing loss and their significant others.
Combined effects for fractional Schrödinger–Kirchhoff systems with critical nonlinearities
Authors: Mingqi Xiang , Rădulescu Vicenţiu D. , Zhang Binlin 
Published: April 2017

In this paper, we investigate the existence of solutions for critical Schrödinger–Kirchhoff type systems driven by nonlocal integro–differential operators. As a particular case, we consider the following system:[see formula in PDF]where (–Δ)spis the fractionalp–Laplace operator with 0 <s< 1 <p<N/s,α,β> 1 withα+β=p*s,M: ℝ+0 → ℝ+0is a continuous function,V: ℝN→ ℝ+is a continuous function, λ > 0 is a real parameter. By applying the mountain pass theorem and Ekeland’s variational principle, we obtain the existence and asymptotic behaviour of solutions for the above systems under some suitable assumptions. A distinguished feature of this paper is that the above systems are degenerate, that is, the Kirchhoff function could vanish at zero. To the best of our knowledge, this is the first time to exploit the existence of solutions for fractional Schrödinger–Kirchhoff systems involving critical nonlinearities in ℝN.