bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non–Small Cell Lung Cancer, and Other Solid Tumors
Authors: Patnaik Amita , Rosen Lee S. , Tolaney Sara M. , Tolcher Anthony W. , Goldman Jonathan W. , Gandhi Leena , Papadopoulos Kyriakos P. , Beeram Muralidhar , Rasco Drew W. , Hilton John F. , Nasir Aejaz , Beckmann Richard P. , Schade Andrew E. , Fulford Angie D. , Nguyen Tuan S. , Martinez Ricardo , Kulanthaivel Palaniappan , Li Lily Q. , Frenzel Martin , Cronier Damien M. , Chan Edward M. , Flaherty Keith T. , Wen Patrick Y. , Shapiro Geoffrey I. 
Published: May 2016

AbstractWe evaluated the safety, pharmacokinetic profile, pharmacodynamic effects, and antitumor activity of abemaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDK) 4 and 6, in a multicenter study including phase I dose escalation followed by tumor-specific cohorts for breast cancer, non–small cell lung cancer (NSCLC), glioblastoma, melanoma, and colorectal cancer. A total of 225 patients were enrolled: 33 in dose escalation and 192 in tumor-specific cohorts. Dose-limiting toxicity was grade 3 fatigue. The maximum tolerated dose was 200 mg every 12 hours. The most common possibly related treatment-emergent adverse events involved fatigue and the gastrointestinal, renal, or hematopoietic systems. Plasma concentrations increased with dose, and pharmacodynamic effects were observed in proliferating keratinocytes and tumors. Radiographic responses were achieved in previously treated patients with breast cancer, NSCLC, and melanoma. For hormone receptor–positive breast cancer, the overall response rate was 31%; moreover, 61% of patients achieved either response or stable disease lasting ≥6 months.Significance: Abemaciclib represents the first selective inhibitor of CDK4 and CDK6 with a safety profile allowing continuous dosing to achieve sustained target inhibition. This first-in-human experience demonstrates single-agent activity for patients with advanced breast cancer, NSCLC, and other solid tumors. Cancer Discov; 6(7); 740–53. ©2016 AACR.See related commentary by Lim et al., p. 697.This article is highlighted in the In This Issue feature, p. 681
МІКРОБІОЛОГІЧНА ХАРАКТЕРИСТИКА СТАТЕВИХ ШЛЯХІВ У ВАГІТНИХ ЖІНОК ПІСЛЯ ЕКСТРАКОРПОРАЛЬНОГО ЗАПЛІДНЕННЯ
Authors: Лісяна Т. О. , Пономарьова І. Г. , Сопко Я. О. , Доброчинська Л. І. , Ковальчук О. А. 
Published: May 2016

<p>Проведено оцінку мікробіоценозу репродуктивного тракту в жінок у різні терміни вагітності після екстракорпорального запліднення (ЕКЗ). Встановлено, що в обстежених пацієнток у першому триместрі вагітності не виявлено суттєвих змін показників контамінації статевих шляхів потенційно патогенною мікрофлорою та збудниками іншої етіології. В другому триместрі вагітності біоценоз статевих шляхів характеризується формуванням дисбалансу між рівнем висіву захисної мікрофлори та представниками транзиторних видів мікроорганізмів, в третьому триместрі вагітності у вагітних відбувається відновлення окремих показників мікробіоценозу репродуктивної системи.</p>
ДИНАМІКА МОЗКОСПЕЦИФІЧНИХ БІЛКІВ ТА НЕЙРОТРОФІЧНОГО ФАКТОРА МОЗКУ (BDNF) У ХВОРИХ ІЗ НАСЛІДКАМИ ЛЕГКОЇ ЧЕРЕПНО-МОЗКОВОЇ ТРАВМИ ДО ТА ПІСЛЯ МІКРОХВИЛЬОВОЇ РЕЗОНАНСНОЇ ТЕРАПІЇ (МРТ)
Authors: Korshnyak O. V. 
Published: May 2016

<p>Показано динаміку стану мозкоспецифічних білків та нейротрофічного фактора (BDNF) у хворих із наслідками легкої черепно-мозкової травми до та після мікрохвильової резонансної терапії. Виявлено, що навіть через досить тривалий час після одержаної черепно-мозкової травми, у даної групи хворих мають місце активні автоімунні реакції до різних структур мозку, що є свідченням порушення регуляторних механізмів у віддаленому періоді легкої черепно-мозкової травми. </p>
БЕЛОК S100 КАК МАРКЕР ГИПЕРТРОФИИ МИОКАРДА У ДЕТЕЙ С ДВУХСТВОРЧАТыМ АОРТАЛЬНыМ КЛАПАНОМ СЕРДЦА
Authors: Каменщик А. В. 
Published: May 2016

<p>В статье приведены результаты изучения сывороточных концентраций белка s100 у детей с двухстворчатым аортальным клапаном сердца (ДаК). Отмечено повышение сывороточных концентраций указаного маркера у детей с ДаК. Проведен корреляционный анализ полученных данных с основными допплерографическими параметрами у данной категории больных детей. По результатам допплерографии выявлено изменение структурной геометрии правых отделов сердца с преобладанием продольного размера правого предсердия и получены уникальные отрицательные корреляции концентраций белка s100 с указанными параметрами допплерэхокардиографии.</p>
Changes in Winter Warming Events in the Nordic Arctic Region
Authors: Vikhamar-Schuler Dagrun , Isaksen Ketil , Haugen Jan Erik , Tømmervik Hans , Luks Bartlomiej , Schuler Thomas Vikhamar , Bjerke Jarle W. 
Published: May 2016

Abstract
In recent years extreme winter warming events have been reported in arctic areas. These events are characterized as extraordinarily warm weather episodes, occasionally combined with intense rainfall, causing ecological disturbance and challenges for arctic societies and infrastructure. Ground-ice formation due to winter rain or melting prevents ungulates from grazing, leads to vegetation browning, and impacts soil temperatures. The authors analyze changes in frequency and intensity of winter warming events in the Nordic arctic region—northern Norway, Sweden, and Finland, including the arctic islands Svalbard and Jan Mayen. This study identifies events in the longest available records of daily temperature and precipitation, as well as in future climate scenarios, and performs analyses of long-term trends for climate indices aimed to capture these individual events. Results show high frequencies of warm weather events during the 1920s–30s and the past 15 years (2000–14), causing weak positive trends over the past 90 years (1924–2014). In contrast, strong positive trends in occurrence and intensity for all climate indices are found for the past 50 years with, for example, increased rates for number of melt days of up to 9.2 days decade−1 for the arctic islands and 3–7 days decade−1 for the arctic mainland. Regional projections for the twenty-first century indicate a significant enhancement of the frequency and intensity of winter warming events. For northern Scandinavia, the simulations indicate a doubling in the number of warming events, compared to 1985–2014, while the projected frequencies for the arctic islands are up to 3 times higher.
Factors influencing emergency nurses’ ethical problems during the outbreak of MERS-CoV
Authors: Choi Jeong-Sil , Kim Ji-Soo 
Published: May 2016

Background: Whenever there has been a worldwide contagious disease outbreak, there have been reports of infection and death of healthcare workers. Particularly because emergency nurses have contact with patients on the front line, they experience ethical problems in nursing while struggling with infectious diseases in an unfavorable environment. Objective: The objective of this study was to explore emergency nurses’ ethical problems and to identify factors influencing these problems during the outbreak of Middle East respiratory syndrome–coronavirus in Korea. Design and sample: For this cross-sectional study, a questionnaire survey was conducted with emergency nurses working in six hospitals selected through convenience sampling from the hospitals designated for Middle East respiratory syndrome–coronavirus patients in the capital area. Methods: Data were collected from 169 emergency nurses in Korea during August 2015. Ethical considerations: This research was approved by the Institutional Review Board of G University in Korea. Results: The findings of this study suggest that during the Middle East respiratory syndrome–coronavirus outbreak, emergency nurses experienced ethical problems tied to a mind-set of avoiding patients. Three factors were found to influence emergency nurses’ ethical problems (in order of influence): cognition of social stigmatization, level of agreement with infection control measures, and perceived risk. Conclusion: Through this study, we obtained information on emergency nurses’ ethical problems during the Middle East respiratory syndrome–coronavirus outbreak and identified the factors that influence them. As found in this study, nurses’ ethical problems were influenced most by cognitions of social stigmatization. Accordingly, to support nurses confidently care for people during future health disasters, it is most urgent to promote appropriate public consciousness that encourages healthcare workers.
Revisiting the reported signal of acute pancreatitis with rasburicase: an object lesson in pharmacovigilance
Authors: Hauben Manfred , Hung Eric Y. 
Published: May 2016

Introduction: There is an interest in methodologies to expeditiously detect credible signals of drug-induced pancreatitis. An example is the reported signal of pancreatitis with rasburicase emerging from a study [the ‘index publication’ (IP)] combining quantitative signal detection findings from a spontaneous reporting system (SRS) and electronic health records (EHRs). The signal was reportedly supported by a clinical review with a case series manuscript in progress. The reported signal is noteworthy, being initially classified as a false-positive finding for the chosen reference standard, but reclassified as a ‘clinically supported’ signal. Objective: This paper has dual objectives: to revisit the signal of rasburicase and acute pancreatitis and extend the original analysis via reexamination of its findings, in light of more contemporary data; and to motivate discussions on key issues in signal detection and evaluation, including recent findings from a major international pharmacovigilance research initiative. Methodology: We used the same methodology as the IP, including the same disproportionality analysis software/dataset for calculating observed to expected reporting frequencies (O/Es), Medical Dictionary for Regulatory Activities Preferred Term, and O/E metric/threshold combination defining a signal of disproportionate reporting. Baseline analysis results prompted supplementary analyses using alternative analytical choices. We performed a comprehensive literature search to identify additional published case reports of rasburicase and pancreatitis. Results: We could not replicate positive findings (e.g. a signal or statistic of disproportionate reporting) from the SRS data using the same algorithm, software, dataset and vendor specified in the IP. The reporting association was statistically highlighted in default and supplemental analysis when more sensitive forms of disproportionality analysis were used. Two of three reports in the FAERS database were assessed as likely duplicate reports. We did not identify any additional reports in the FAERS corresponding to the three cases identified in the IP using EHRs. We did not identify additional published reports of pancreatitis associated with rasburicase. Discussion: Our exercise stimulated interesting discussions of key points in signal detection and evaluation, including causality assessment, signal detection algorithm performance, pharmacovigilance terminology, duplicate reporting, mechanisms for communicating signals, the structure of the FAERs database, and recent results from a major international pharmacovigilance research initiative.
Up/down and P/S decompositions of elastic wavefields using complex seismic traces with applications to calculating Poynting vectors and angle-domain common-image gathers from reverse time migrations
Authors: Wang Wenlong , McMechan George A. , Tang Chen , Xie Fei 
Published: May 2016

Separations of up- and down-going as well as of P- and S-waves are often a part of processing of multicomponent recorded data and propagating wavefields. Most previous methods for separating up/down propagating wavefields are expensive because of the requirement to save time steps to perform Fourier transforms over time. An alternate approach for separation of up-and down-going waves, based on extrapolation of complex data traces is extended from acoustic to elastic, and combined with P- and S-wave decomposition by decoupled propagation. This preserves all the information in the original data and eliminates the need for a Fourier transform over time, thereby significantly reducing the storage cost and improving computational efficiency. Wavefield decomposition is applied to synthetic elastic VSP data and propagating wavefield snapshots. Poynting vectors obtained from the particle velocity and stress fields after P/S and up/down decompositions are much more accurate than those without because interference between the corresponding wavefronts is significantly reduced. Elastic reverse time migration with the P/S and up/down decompositions indicated significant improvement compared with those without decompositions, when applied to elastic data from a portion of the Marmousi2 model.
No Evidence for the Benefit of Gonadotropin-Releasing Hormone Agonist in Preserving Ovarian Function and Fertility in Lymphoma Survivors Treated With Chemotherapy: Final Long-Term Report of a Prospective Randomized Trial
Authors: Demeestere Isabelle , Brice Pauline , Peccatori Fedro A. , Kentos Alain , Dupuis Jehan , Zachee Pierre , Casasnovas Olivier , Van Den Neste Eric , Dechene Julie , De Maertelaer Viviane , Bron Dominique , Englert Yvon 
Published: May 2016

Purpose We have reported previously that after 1-year follow up, gonadotropin-releasing hormone agonist (GnRHa) did not prevent chemotherapy-induced premature ovarian failure (POF) in patients with lymphoma, but may provide protection of the ovarian reserve. Here, we report the final analysis of the cohort after 5 years of follow up. Patients and Methods A total of 129 patients with lymphoma were randomly assigned to receive either triptorelin plus norethisterone (GnRHa group) or norethisterone alone (control group) during chemotherapy. Ovarian function and fertility were reported after 2, 3, 4, and 5 to 7 years of follow up. The primary end point was POF, defined as at least one follicle-stimulating hormone value of > 40 IU/L after 2 years of follow up. Results Sixty-seven patients 26.21 ± 0.64 years of age had available data after a median follow-up time of 5.33 years in the GnRHa group and 5.58 years in the control group (P = .452). Multivariate logistic regression analysis showed a significantly increased risk of POF in patients according to age (P = .047), the conditioning regimen for hematopoietic stem cell transplant (P = .002), and the cumulative dose of cyclophosphamide > 5 g/m2 (P = .019), but not to the coadministration of GnRHa during chemotherapy (odds ratio, 0.702; P = .651). The ovarian reserve, evaluated using anti-Müllerian hormone and follicle-stimulating hormone levels, was similar in both groups. Fifty-three percent and 43% achieved pregnancy in the GnRHa and control groups, respectively (P = .467). Conclusion To the best of our knowledge, this is the first long-term analysis confirming that GnRHa is not efficient in preventing chemotherapy-induced POF in young patients with lymphoma and did not influence future pregnancy rate. These results reopen the debate about the drug’s benefit in that it should not be recommended as standard for fertility preservation in patients with lymphoma.
Physiological profiles associated with ceasing growth of unfertilized eggs produced by unmated queens in the subterranean termite Reticulitermes chinensis
Authors: Li Ganghua , Liu Long , Sun Pengdong , Wu Yao , Lei Chaoliang , Chen Xiongwen , Huang Qiuying 
Published: May 2016

ABSTRACT
In Reticulitermes chinensis, a close relative of R.speratus with asexual queen succession, unfertilized eggs can be produced but do not hatch as larvae. To explain this phenomenon, we analyzed the physiological differences between unfertilized eggs/unmated queens and fertilized eggs/mated queens. Fertilized eggs had significantly lower quantities of five amino acids (Cys, Met, Ile, Leu and Tyr), Ca, protein and cholesterol during development. The higher levels of four trace elements (Na, K, Zn and Fe) in fertilized eggs and their lower levels in mated queens indicated that mated queens might transfer these trace elements to fertilized eggs to aid development. The higher levels of Mn, triglycerides and serotonin in mated queens and higher levels of Mn and glucose in fertilized eggs suggested that these substances are very important for normal ovarian and embryonic growth. The different expression of three reproductive genes (vtg 1, rab 11 and JHE 1) suggested that they might be involved in the regulation of ovarian and embryonic growth. Overall, changes in these physiological indices may substantially affect ovarian and embryonic growth and inhibit development of unfertilized eggs in R. chinensis.
Metabolomics reveals significant variations in metabolites and correlations regarding the maturation of walnuts (Juglans regia L.)
Authors: Rao Guodong , Sui Jinkai , Zhang Jianguo 
Published: May 2016

ABSTRACT
The content of walnut metabolites is related to its nutritive value and physiological characteristics, however, comprehensive information concerning the metabolome of walnut kernels is limited. In this study we analyzed the metabolites of walnut kernels at five developmental stages from filling to ripening using GC-MS-based untargeted metabolomics; of a total 252 peaks identified, 85 metabolites were positively identified. Further statistical analysis revealed that these 85 metabolites covered different types of metabolism pathways. PCA scores revealed that the metabolic compositions of the embryo are different at each stage, while the metabolic composition of the endotesta could not be significantly separated into distinct groups. Additionally, 7225 metabolite-metabolite correlations were detected in walnut kernel by a Pearson correlation coefficient approach; during screening of the calculated correlations, 463 and 1047 were determined to be significant with r2≥0.49 and had a false discovery rate (FDR) ≤0.05 in endotesta and embryo, respectively. This work provides the first comprehensive metabolomic study of walnut kernels and reveals that most of the carbohydrate and protein-derived carbon was transferred into other compounds, such as fatty acids, during the maturation of walnuts, which may potentially provide the basis for further studies on walnut kernel metabolism.
SMN and coilin negatively regulate dyskerin association with telomerase RNA
Authors: Poole Aaron R. , Hebert Michael D. 
Published: May 2016

ABSTRACT
Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins. CBs also contribute to the delivery of telomerase to telomeres. The protein WRAP53 is enriched within the CB and is instrumental for the targeting of telomerase RNA to CBs. Two other CB proteins, SMN and coilin, are also suspected of taking part in some aspect of telomerase biogenesis. Here we demonstrate newly discovered associations between SMN and coilin with telomerase components, and further show that reduction of SMN or coilin is correlated with increased association of telomerase RNA with one these components, dyskerin. These findings argue that SMN and coilin may negatively regulate the formation of telomerase. Furthermore, clinically defined SMN mutants found in individuals with spinal muscular atrophy are altered in their association with telomerase complex proteins. Additionally, we observe that a coilin derivative also associates with dyskerin, and the amount of this protein in the complex is regulated by SMN, WRAP53 and coilin levels. Collectively, our findings bolster the link between SMN, coilin and the coilin derivative in the biogenesis of telomerase.
ΒΕΝΙΖΕΛΙΣΜΟΣ ΚΑΙ ΕΘΝΙΚΟ ΠΑΡΕΛΘΟΝ: ΤΟ ΕΡΓΟ ΤΗΣ ΚΕΝΤΡΙΚΗΣ ΕΠΙΤΡΟΠΗΣ ΕΚΑΤΟΝΤΑΕΤΗΡΙΔΟΣ (1928-1933)
Authors: ΤΡΙΑΝΤΑΦΥΛΛΟΥ ΧΡΗΣΤΟΣ 
Published: May 2016

<p>Δεν παρατίθεται περίληψη στα ελληνικά.</p><p> </p>
Writi ng with the small, smart screen: Mobile phones, automated editing and holding on to creative agency
Authors: Frankham Bettina 
Published: May 2016

Abstract
Media practitioners find themselves in contradictory times. Smartphones that are able to capture highresolution sound and image are facilitating a consistent, abiding and thoughtful practice so that media production is more affordable and ready-at-hand than ever before. At the same time, increasingly sophisticated software is being developed to automate what have previously been considered skilled tasks, such as editing, curating and colour grading. While still an emerging field, these incursions have the potential to pose serious threats to the creative agency of individual moving image-makers. From a first-person practitioner perspective, this article considers how the creative agency of a critically engaged moving-image practice is both enabled and threatened by smartphone production environments. Using the lens of cinécriture, I consider how the full range of production choices becomes part of the expressive tool kit and the importance of making these aspects of creative agency conscious. I argue for the value of conceptual engagement through practice so that the act of participation and making is emphasized, and the significance of human creativity is maintained. Through an examination of the Google Photo Assistant application as an example of a basic automated editing tool, and setting my own approach to moving-image practice in this context, I put forward the case that greater digital literacy is required if practitioners are to maintain satisfactory levels of creative agency.
Avaliação das condições higiênico-sanitárias em pizzarias na cidade de Marabá, Pará, Brasil
Authors: Martins Dinamar Dos Anjos , Carneiro Juliana Lima , Pereira Josceane Da Cruz , Cordovil Suelane Rodrigues , Da Silva Bruna Almeida 
Published: May 2016

Objetivo do trabalho foi avaliar as condições higiênico-sanitárias de três pizzarias da cidade de Marabá-PA. Para avaliação dos estabelecimentos A, B e C foi desenvolvido com base nas RDC nº 216 e 275, um check-list composto por 57 perguntas relacionadas aos seguintes itens: I - Edificação, instalações, equipamentos, móveis e utensílios; II - Higienização de instalações, equipamentos, móveis e utensílios; III - Controle integrado de vetores e pragas urbanas; IV - Abastecimento de água; V- Manejo dos resíduos; VI - Manipuladores; VII - Matérias-primas, ingredientes e embalagens. Para a avaliação dos resultados foram utilizados os seguintes critérios: excelente > 91%; bom ≥ 70 a 90%; regular ≥ 50 a 69%; ruim ≥ 20 a 49% e péssimo < 19%. As pizzarias A, B e C apresentaram os seguintes resultados: item (I) 34%, 96% e 52%; item (II) 40%, 83% e 29%; item (III) 63%, 88% e 25%; item (IV) 70%, 95% e 50%; item (V) 67%, 100% e 59%; item (VI) 63%, 84% e 36%; item (VII) 50%, 93% e 50% respectivamente. Conclui-se que dentre a pizzaria B apresentou os maiores índices de conformidade aos itens analisados e os resultados encontrados nas pizzarias A e C, foram preocupantes, sendo assim, necessário a realização de cursos de boas práticas de fabricação aos manipuladores, para capacita-los conforme as atividades desenvolvidas. Concluiu-se que os estabelecimentos analisados somente um encontra-se em condição higiênico-sanitária adequada, sendo que o comprometimento de todos os envolvidos é uma condição básica para a eficácia na higiene.