bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Initial Evaluation of the Impact of Pokémon GO on Physical Activity
Authors: Xian Ying , Xu Hanzhang , Xu Haolin , Liang Li , Hernandez Adrian F. , Wang Tracy Y. , Peterson Eric D. 
Published: May 2017

Background

Pokémon GO is a location‐based augmented reality game. Using
GPS
and the camera on a smartphone, the game requires players to travel in real world to capture animated creatures, called Pokémon. We examined the impact of Pokémon GO on physical activity (
PA
).

Methods and Results

A pre‐post observational study of 167 Pokémon GO players who were self‐enrolled through recruitment flyers or online social media was performed. Participants were instructed to provide screenshots of their step counts recorded by the
iP
hone Health app between June 15 and July 31, 2016, which was 3 weeks before and 3 weeks after the Pokémon GO release date. Of 167 participants, the median age was 25 years (interquartile range, 21–29 years). The daily average steps of participants at baseline was 5678 (
SD
, 2833; median, 5718 [interquartile range, 3675–7279]). After initiation of Pokémon GO, daily activity rose to 7654 steps (
SD
, 3616; median, 7232 [interquartile range, 5041–9744], pre‐post change: 1976; 95%
CI
, 1494–2458, or a 34.8% relative increase [
P
<0.001]). On average, 10 000 “
XP
” points (a measure of game progression) was associated with 2134 additional steps per day (95%
CI
, 1673–2595), suggesting a potential dose‐response relationship. The number of participants achieving a goal of 10 000+ steps per day increased from 15.3% before to 27.5% after (odds ratio, 2.06; 95%
CI
, 1.70–2.50). Increased
PA
was also observed in subgroups, with the largest increases seen in participants who spent more time playing Pokémon GO, those who were overweight/obese, or those with a lower baseline
PA
level.

Conclusions

Pokémon GO participation was associated with a significant increase in
PA
among young adults. Incorporating
PA
into gameplay may provide an alternative way to promote
PA
in persons who are attracted to the game.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
02888314.
Sensitivity of CONUS Summer Rainfall to the Selection of Cumulus Parameterization Schemes in NU-WRF Seasonal Simulations
Authors: Iguchi Takamichi , Tao Wei-Kuo , Wu Di , Peters-Lidard Christa , Santanello Joseph A. , Kemp Eric , Tian Yudong , Case Jonathan , Wang Weile , Ferraro Robert , Waliser Duane , Kim Jinwon , Lee Huikyo , Guan Bin , Tian Baijun , Loikith Paul 
Published: May 2017

Abstract
This study investigates the sensitivity of daily rainfall rates in regional seasonal simulations over the contiguous United States (CONUS) to different cumulus parameterization schemes. Daily rainfall fields were simulated at 24-km resolution using the NASA-Unified Weather Research and Forecasting (NU-WRF) Model for June–August 2000. Four cumulus parameterization schemes and two options for shallow cumulus components in a specific scheme were tested. The spread in the domain-mean rainfall rates across the parameterization schemes was generally consistent between the entire CONUS and most subregions. The selection of the shallow cumulus component in a specific scheme had more impact than that of the four cumulus parameterization schemes. Regional variability in the performance of each scheme was assessed by calculating optimally weighted ensembles that minimize full root-mean-square errors against reference datasets. The spatial pattern of the seasonally averaged rainfall was insensitive to the selection of cumulus parameterization over mountainous regions because of the topographical pattern constraint, so that the simulation errors were mostly attributed to the overall bias there. In contrast, the spatial patterns over the Great Plains regions as well as the temporal variation over most parts of the CONUS were relatively sensitive to cumulus parameterization selection. Overall, adopting a single simulation result was preferable to generating a better ensemble for the seasonally averaged daily rainfall simulation, as long as their overall biases had the same positive or negative sign. However, an ensemble of multiple simulation results was more effective in reducing errors in the case of also considering temporal variation.
Jet–Topography Interactions Affect Energy Pathways to the Deep Southern Ocean
Authors: Barthel Alice , McC. Hogg Andrew , Waterman Stephanie , Keating Shane 
Published: May 2017

AbstractIn the Southern Ocean, strong eastward ocean jets interact with large topographic features, generating eddies that feed back onto the mean flow. Deep-reaching eddies interact with topography, where turbulent dissipation and generation of internal lee waves play an important role in the ocean’s energy budget. However, eddy effects in the deep ocean are difficult to observe and poorly characterized. This study investigates the energy contained in eddies at depth, when an ocean jet encounters topography. This study uses a two-layer ocean model in which an imposed unstable jet encounters a topographic obstacle (either a seamount or a meridional ridge) in a configuration relevant to an Antarctic Circumpolar Current frontal jet. The authors find that the presence of topography increases the eddy kinetic energy (EKE) at depth but that the dominant processes generating this deep EKE depend on the shape and height of the obstacle as well as on the baroclinicity of the jet before it encounters topography. In cases with high topography, horizontal shear instability is the dominant source of deep EKE, while a flat bottom or a strongly sheared inflow leads to deep EKE being generated primarily through baroclinic instability. These results suggest that the deep EKE is set by an interplay between the inflowing jet properties and topography and imply that the response of deep EKE to changes in the Southern Ocean circulation is likely to vary across locations depending on the topography characteristics.
Spherical Harmonic Spectral Estimation on Arbitrary Grids
Authors: Cavanaugh Nicholas R. , O’Brien Travis A. , Collins William D. , Skamarock William C. 
Published: May 2017

AbstractThis study explores the use of nonuniform fast spherical Fourier transforms on meteorological data that are arbitrarily distributed on the sphere. The applicability of this methodology in the atmospheric sciences is demonstrated by estimating spectral coefficients for nontrivial subsets of reanalysis data on a uniformly spaced latitude–longitude grid, a global cloud resolving model on an icosahedral mesh with 3-km horizontal grid spacing, and for temperature anomalies from arbitrarily distributed weather stations over the United States. A spectral correction technique is developed that can be used in conjunction with the inverse transform to yield data interpolated onto a uniformly spaced grid, with optional triangular truncation, at reduced computational cost compared to other variance conserving interpolation methods, such as kriging or natural spline interpolation. The spectral correction yields information that can be used to deduce gridded observational biases not directly available from other methods.
Proactive QC: A Fully Flow-Dependent Quality Control Scheme Based on EFSO
Authors: Hotta Daisuke , Chen Tse-Chun , Kalnay Eugenia , Ota Yoichiro , Miyoshi Takemasa 
Published: May 2017

AbstractDespite dramatic improvements over the last decades, operational NWP forecasts still occasionally suffer from abrupt drops in their forecast skill. Such forecast skill “dropouts” may occur even in a perfect NWP system because of the stochastic nature of NWP but can also result from flaws in the NWP system. Recent studies have shown that dropouts occur due not to a model’s deficiencies but to misspecified initial conditions, suggesting that they could be mitigated by improving the quality control (QC) system so that the observation-minus-background (O-B) innovations that would degrade a forecast can be detected and rejected. The ensemble forecast sensitivity to observations (EFSO) technique enables for the quantification of how much each observation has improved or degraded the forecast. A recent study has shown that 24-h EFSO can detect detrimental O-B innovations that caused regional forecast skill dropouts and that the forecast can be improved by not assimilating them. Inspired by that success, a new QC method is proposed, termed proactive QC (PQC), that detects detrimental innovations 6 h after the analysis using EFSO and then repeats the analysis and forecast without using them. PQC is implemented and tested on a lower-resolution version of NCEP’s operational global NWP system. It is shown that EFSO is insensitive to the choice of verification and lead time (24 or 6 h) and that PQC likely improves the analysis, as attested to by forecast improvements of up to 5 days and beyond. Strategies for reducing the computational costs and further optimizing the observation rejection criteria are also discussed.
Short Stature Is Associated With Overweight but Not With High Energy Intake in Low-Income Quilombola Women
Authors: Ferreira Haroldo da Silva , Luna Andreza A. , Florêncio Telma Maria M. T. , Assunção Monica L. , Horta Bernardo L. 
Published: May 2017

Background: Population exposed to chronic undernutrition in early life seems to be more susceptible to obesity in adulthood due to the development of mechanisms that improve the efficiency of energy use. Therefore, these individuals have relatively reduced energy requirements (thrifty phenotype). Objective: To investigate, among women living on severe socioeconomic vulnerability, whether short stature, a marker for undernutrition in early life, is associated with excess body weight but not with a high energy intake. Methods: This cross-sectional study, carried out between July and November 2008, evaluated 1308 women from all (N = 39) Quilombola communities of Alagoas. Adequacy of energy intake was estimated by the ratio between energetic ingestion and the estimated energy requirement (EER). Results: The prevalence of short stature (≤ 154.8 cm) was 43.0% and 52.4% had excess body weight (body mass index ≥ 25 kg/m2), being that 33.1% were overweight and 19.3% obese. Excess body weight was higher among women with short stature (56.6% vs 49.2%; P = .008), even after adjusting for age, energy intake, and per capita income (prevalence ratio = 1.16; 95% confidence interval = 1.04; 1.28). The ratio of energy intake/EER was independent of women’s stature. Conclusion: Excess body weight among Quilombola women represents a serious health problem. Short stature was significantly associated with excess body weight but not with a high energy intake. “Thrifty phenotype” may be one of the plausible explanations for this finding.
Theoretical Foundations of Appeals Used in Alcohol-Abuse and Drunk-Driving Public Service Announcements in the United States, 1995-2010
Authors: Niederdeppe Jeff , Avery Rosemary J. , Miller Emily Elizabeth Namaste 
Published: May 2017

Purpose: The study identifies the extent to which theoretical constructs drawn from well-established message effect communication theories are reflected in the content of alcohol-related public service announcements (PSAs) airing in the United States over a 16-year period. Design: Content analysis of 18 530 141 alcohol-abuse (AA) and drunk-driving (DD) PSAs appearing on national network and local cable television stations in the 210 largest designated marketing areas (DMAs) from January 1995 through December 2010. Measures: The authors developed a detailed content analytic codebook and trained undergraduate coders to reliably identify the extent to which theoretical constructs and other creative ad elements are reflected in the PSAs. We show these patterns using basic descriptive statistics. Results: Although both classes of alcohol-related PSAs used strategies that are consistent with major message effect theories, their specific theoretical orientations differed dramatically. The AA PSAs were generally consistent with constructs emphasized by the Extended Parallel Process Model (EPPM), whereas DD PSAs were more likely to use normative strategies emphasized by the Focus Theory of Narrative Conduct (FTNC) or source credibility appeals central to the Elaboration Likelihood Model. Conclusion: Having identified message content, future research should use deductive approaches to determine if volume and message content of alcohol-control PSAs have an impact on measures of alcohol consumption and/or measures of drunk driving, such as fatalities or driving while intoxicated/driving under the influence arrests.
Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis
Authors: Balk Lisanne J , Coric Danko , Nij Bijvank Jenny A , Killestein Joep , Uitdehaag Bernard MJ , Petzold Axel 
Published: May 2017

Background: Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration. Objective: To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA) and vision-related quality of life (QoL) and to investigate the effect of previous episodes on MS-associated optic neuritis (MSON). Methods: Spectral-domain optical coherence tomography (SD-OCT) was performed in 267 patients with MS. Images were segmented for the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell inner plexiform layer (GCIPL). Ophthalmological evaluations included history of MSON, HCVA, LCVA, and vision-related QoL. Results: Independent of MSON, HCVA and LCVA were significantly associated with pRNFL and GCIPL thicknesses. Vision-related QoL was positively associated with pRNFL (β = 0.92, p = 0.06) and GCIPL (β = 0.93, p = 0.02) thicknesses. These associations were independent of MSON. Not only binocular but also monocular atrophy of the inner retinal layers was associated with lower vision-related QoL. Conclusion: This study showed that retinal atrophy has a significant impact on visual functioning in patients with MS. OCT may therefore provide useful insight to patients with visual dysfunction, and our findings support including OCT and vision-related QoL measures into optic neuritis treatment trials.
The effectiveness of ultrasound guided hydrodistension and physiotherapy in the treatment of frozen shoulder/adhesive capsulitis in primary care: a single centre service evaluation
Authors: Bryant Michael , Gough Andrew , Selfe James , Richards Jim , Burgess Elizabeth 
Published: May 2017

Background Evidence for optimal non-operative treatment of frozen shoulder is lacking. The present study aimed to evaluate a treatment strategy for stage II to III frozen shoulder provided by the current primary care musculoskeletal service. Methods General practioner referrals of shoulder pain to the musculoskeletal service diagnosed with stage II to III frozen shoulder and who opted for a treatment strategy of hydrodistension and guided physiotherapy exercise programme over a 12-month period were evaluated for 6 months. Thirty-three patients were diagnosed with stage II to III frozen shoulder by specialist physiotherapists and opted for the treatment strategy. Outcome measures included Shoulder Pain Disability Index (SPADI) and Shortened Disabilities of the Arm, Shoulder and Hand (QuickDASH), pain score and range of movement. Data were collected at baseline, as well as at 6 weeks, 12 weeks and 6 months. Results All patients significantly improved in shoulder symptoms on the SPADI and QuickDASH scores ( p < 0.001). Pain scores and range of shoulder movement flexion, abduction, external rotation showed significant improvement at all time points ( p < 0.001). Conclusions This service evaluation demonstrates that management of frozen shoulder stage II to III, as conducted by physiotherapists in a primary care setting utilizing hydrodistension and a guided exercise programme, represents an effective non-operative treatment strategy.
Three Cycles of Radiofrequency Ablation Are More Efficacious Than Two in the Management of Morton’s Neuroma
Authors: Brooks David , Parr Adam , Bryceson William 
Published: May 2017

Background. Morton’s neuroma is a common cause of forefoot pain. Outcomes of conservative therapy are mixed and many patients undergo operative intervention. Radiofrequency ablation has recently gained favor as a treatment option, although the optimal regime is unknown. This study investigates the effectiveness of 2 versus 3 cycles of radiofrequency ablation for the treatment of Morton’s neuroma. Methods. We surveyed a cohort of patients with Morton’s neuroma who had progressed to radiofrequency ablation after failed conservative treatment. Patients received either 2 or 3 cycles of radiofrequency ablation by a single surgeon. We assessed patients based on their change in numerical pain rating scale, symptom improvement, complications, and progression to surgical excision through a series of telephone interviews. Outcomes between the 2 treatment arms were compared by parametric tests. Results. Twenty-eight patients were included in the study. Eighteen patients with 21 neuromas received 2 cycles and 10 patients with 11 neuromas received 3 cycles. Mean time of follow-up was 12.9 months. Overall, 88% of patients were either very or moderately satisfied with their outcome. In patients who received 2 cycles mean numerical pain scores decreased from 7.9 ± 1.1 to 3.4 ± 2.4 postprocedure. Three patients progressed to operative excision. In patients who received 3 cycles, numerical pain scores decreased from 8.0 ± 1.0 to 1.5 ± 2.0 postprocedure. One patient progressed to operative excision. Patients who received 3 cycles had reduced medium-term pain postoperatively compared with 2 cycles (3.4 ± 2.4 vs 1.5 ± 2.0, P = .011). Conclusion. Radiofrequency ablation provides a high rate of patient satisfaction in the treatment of Morton’s neuroma with few side effects. It appears that 3 cycles may be superior to 2 cycles but a randomized controlled trial will be required to confirm these results. Levels of Evidence: Intervention, Level III: Comparative study without concurrent controls
A Preliminary Study on the Effect of Computer-Aided Designed and Manufactured Orthoses on Chronic Plantar Heel Pain
Authors: Gatt Alfred , Grech Mark , Chockalingam Nachiappan , Formosa Cynthia 
Published: May 2017

Introduction. Chronic plantar heel pain (CPHP) is a significant, painful condition referring to a range of undifferentiated foot conditions that affect the heel of the foot. Method. Participants presenting with CPHP of more than 6 months’ duration were recruited on a first through the door basis. Computer-Aided Design and Computer-Aided Manufactured (CAD-CAM) orthoses were designed and constructed for each participant, then dispensed as per normal practice. Pre- and postintervention assessment of pain was performed at baseline and after 6 weeks of use, utilizing the pain subset of the Foot Function Index (FFI). Results. There was a significant reduction in the mean pain scores for all participants in all constructs of the FFI. Total FFI score was also significant ( P = .003). Conclusion. CAD-CAM orthoses have the potential to become a treatment modality of choice in CPHP since they have resulted in a significant improvement in heel pain after only 6 weeks’ use. Levels of Evidence: Therapeutic, Level IV: Prospective, comparative trial
Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies
Authors: Fallon Marie T , Albert Lux Eberhard , McQuade Robert , Rossetti Sandro , Sanchez Raymond , Sun Wei , Wright Stephen , Lichtman Aron H , Kornyeyeva Elena 
Published: May 2017

Background: Opioids are critical for managing cancer pain, but may provide inadequate relief and/or unacceptable side effects in some cases. Objective: To assess the analgesic efficacy of adjunctive Sativex (Δ9-tetrahydrocannabinol (27 mg/mL): cannabidiol (25 mg/mL)) in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy. Methods: This report describes two phase 3, double-blind, randomized, placebo-controlled trials. Eligible patients had advanced cancer and average pain numerical rating scale (NRS) scores ≥4 and ≤8 at baseline, despite optimized opioid therapy. In Study-1, patients were randomized to Sativex or placebo, and then self-titrated study medications over a 2-week period per effect and tolerability, followed by a 3-week treatment period. In Study-2, all patients self-titrated Sativex over a 2-week period. Patients with a ≥15% improvement from baseline in pain score were then randomized 1:1 to Sativex or placebo, followed by 5-week treatment period (randomized withdrawal design). Results: The primary efficacy endpoint (percent improvement (Study-1) and mean change (Study-2) in average daily pain NRS scores) was not met in either study. Post hoc analyses of the primary endpoints identified statistically favourable treatment effect for Sativex in US patients <65 years (median treatment difference: 8.8; 95% confidence interval (CI): 0.00–17.95; p = 0.040) that was not observed in patients <65 years from the rest of the world (median treatment difference: 0.2; 95% CI: −5.00 to 7.74; p = 0.794). Treatment effect in favour of Sativex was observed on quality-of-life questionnaires, despite the fact that similar effects were not observed on NRS score. The safety profile of Sativex was consistent with earlier studies, and no evidence of abuse or misuse was identified. Conclusions: Sativex did not demonstrate superiority to placebo in reducing self-reported pain NRS scores in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy, although further exploration of differences between United States and patients from the rest of the world is warranted.