bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Legacy of Liberation Theology in Colombia
Authors: Celis Leila 
Published: March 2016

Liberation theology was very important in Latin America between 1970 and 1980. While it is less significant today, it has not disappeared. If we look at Colombia, we can see the pastoral and political commitment of the religious and the laity in various regions as they accompany marginalized communities, victims of government and parastatal violence, in conformity with their preferential option for the poor. Motivated by the crucified Christ, the heirs of liberation theology have developed a theology of life or of human rights. As human rights advocates, they identify among the causes of violence the policies of capitalist development, denounced as imperialist and responsible for the poverty of the majority of the population. This development has its origin in the parallel dynamics of social and international relations and the associated adaptation of the social movement. La teología de la liberación tuvo mucha importancia en América Latina entre los años 1970 y 1980. Bien que hoy ella sea menos relevante, no ha desaparecido. Si tomamos el caso de Colombia podemos ver el compromiso pastoral y político de laicos y religiosos presentes en diferentes regiones del país, quienes consecuentes ante su opción preferencial por los pobres están acompañando comunidades marginalizadas, víctimas de la violencia estatal y paraestatal. Inspirados en Jesús crucificado, los herederos de la teología de la liberación han hilado una teología de los derechos humanos o de la vida. Como defensores de derechos humanos, ellos identifican dentro de las causas de la violencia las políticas de desarrollo capitalista, denunciadas como imperialistas y como responsables de la miseria de las grandes mayorías. Esta trasformación se origina en la dinámica paralela de las relaciones sociales e internacionales y la adaptación consecuente del movimiento social.
Effect of ejection fraction on left ventricular remodeling in aortic insufficiency
Authors: Gunay Deniz , Ozen Yucel , Cekmecelioglu Davut , Sarikaya Sabit , Aksoy Eray , Rabus Murat Bulent , Kirali Kaan 
Published: March 2016

Background Due to ventricular compensatory mechanisms, patients with severe aortic regurgitation are generally asymptomatic. Severe left ventricular dysfunction develops annually in 20% of non-operated cases, and the prognosis in those cases is poor. Although surgery is recommend in patients with left ventricular dysfunction, surgeons are wary. We investigated the changes in ventricular and effort capacity after surgery in patients with normal and abnormal left ventricular function. Methods We retrospectively examined the data of patients with aortic regurgitation who underwent aortic valve replacement in our clinic between 1993 and 2013. Those who had previous cardiac surgery, chemotherapy, radiotherapy, renal dysfunction, diabetes mellitus, or preoperative arrhythmias were excluded. The 113 patients were divided into 2 groups according to ejection fraction. Results In patients with ejection fraction <50%, interventricular septal thickness, posterior wall thickness, and left ventricular mass were significantly greater than in the ejection fraction ≥50% group ( p < 0.01). No significant differences in intensive care unit stay and hospitalization were determined. No mortality was observed. Ejection fraction and effort capacity increased significantly after aortic valve replacement in both groups, and interventricular septal thickness, posterior wall thickness, and left ventricular mass decreased in both groups. Conclusions Significant left ventricular functional improvements can be achieved after aortic valve replacement in patients with severe aortic regurgitation who develop left ventricular dysfunction. Despite the reported higher surgical mortality in this patient group, surgical treatment offers a survival benefit. We recommend surgical treatment in patients with severe aortic regurgitation who develop left ventricular dysfunction.
Mid-term outcome of endovascular treatment for acute lower extremity deep venous thrombosis
Authors: Jiang Kun , Li Xiao-Qiang , Sang Hong-Fei , Qian Ai-Min , Rong Jian-Jie , Li Cheng-Long 
Published: March 2016

Purposes of the study To evaluate the benefit of stenting the iliac vein in patients with residual iliac vein stenosis treated with catheter-directed thrombolysis for acute iliofemoral deep venous thrombosis. Procedures In this randomized prospective study, patients with a first-time acute lower extremity deep venous thrombosis that had persisted <14 days were treated with catheter-directed thrombolysis. After catheter-directed thrombolysis, patients with >50% residual iliac vein stenosis were randomly divided into two groups: catheter-directed thrombolysis + Stent Group and catheter-directed thrombolysis Alone Group. Patients received urokinase thrombolysis and low-molecular-weight heparin/oral warfarin during the hospitalization period and were administrated oral warfarin after discharge. Cumulative deep vein patency, the Clinical Etiology Anatomic Pathophysiologic classification system, the Venous Clinical Severity Score and the Chronic Venous Insufficiency Questionnaire score were evaluated. Findings The cumulative deep vein patency rate was 74.07% in the catheter-directed thrombolysis + Stent Group and 46.59% in the catheter-directed thrombolysis Alone Group. The mean postoperative Clinical Etiology Anatomic Pathophysiologic classification and Venous Clinical Severity Score was significantly lower in the catheter-directed thrombolysis + Stent Group than in the catheter-directed thrombolysis Alone Group. The mean postoperative Chronic Venous Insufficiency Questionnaire score was significantly higher in the catheter-directed thrombolysis + Stent Group than the catheter-directed thrombolysis Alone Group. Conclusions Placement of an iliac vein stent in patients with residual iliac vein stenosis after catheter-directed thrombolysis for acute lower extremity deep venous thrombosis increases iliac vein patency and improves clinical symptoms and health-related quality of life at mid-term follow-up compared to patients treated with catheter-directed thrombolysis alone.
Serial Changes of the Cartilage in Recipient Sites and Their Mirror Sites on Second-Look Imaging After Mosaicplasty
Authors: Nakagawa Yasuaki , Mukai Shogo , Yabumoto Hiromitsu , Tarumi Eri , Nakamura Takashi 
Published: March 2016

Background: It has been reported that the short-term results of mosaicplasty are good, but there have been no reports of the serial cartilage changes in the recipient sites and their mirror sites for mosaicplasty. Purpose: To examine the serial changes in cartilage in the recipient sites and their mirror sites using second-look imaging. Study Design: Case series; Level of evidence, 4. Methods: A total of 33 patients (37 knees, 40 sites) underwent mosaicplasty and second-look arthroscopy at a single institution over a 7-year period. There were 14 men and 19 women (12 right knees and 25 left knees). The recipient sites were the patella (n = 3), trochlea (n = 7), medial femoral condyle (n = 21), and lateral femoral condyle (n = 9). The mean patient age at surgery was 38.3 years; the mean period from mosaicplasty to second-look arthroscopy was 15.4 months; and the mean follow-up period was 34.9 months (range, 24-65 months). The results of second-look arthroscopy at the recipient site were categorized as cartilage with a smooth surface (group S) and fibrillation or an irregular surface (group I), and results of second-look arthroscopy at the mirror site were categorized as worse (group W), improved (group E), and unchanged (group U). Results: There were 30 sites in group S, 10 sites in group I, 3 sites in group W, 4 sites in group E, and 33 sites in group U. The age at operation was significantly greater in group S than in group I. There was a significant correlation between group S and groups E and U. The clinical outcome was significantly worse in group W when compared with groups E and U. Conclusion: If a smooth surface was seen in the recipient site during second-look arthroscopy, the cartilage degeneration in its mirror site did not become worse after mosaicplasty.
Precollegiate Knee Surgery Predicts Subsequent Injury Requiring Surgery in NCAA Athletes
Authors: Wang Dean , Rugg Caitlin M. , Mayer Erik , Lai Wilson C. , Sulzicki Pamela , Vail Jeremy , Hame Sharon L. 
Published: March 2016

Background: The effect of precollegiate orthopaedic surgery on injury risk in the elite collegiate athlete is unknown. Purpose: To (1) assess the relationship between precollegiate surgery and subsequent injury requiring surgery in National Collegiate Athletic Association (NCAA) Division I athletes at a single institution and (2) compare the risk of subsequent surgery in the ipsilateral versus contralateral extremity in those with a history of precollegiate surgery. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective chart review was performed of all athletes who began participation from 2003 to 2009 until completion of eligibility. Athletes who received orthopaedic surgery in college were identified through the Sports Injury Monitoring System and were cross-referenced with medical records. The risk of orthopaedic surgery was evaluated using multivariate Cox and Poisson regression models, with sex and sport as additional covariates. Risk of subsequent surgery in the ipsilateral versus contralateral extremity was compared using Kaplan-Meier survival estimates and Cox proportional hazards regression. Hazard ratios (HRs) and rate ratios (RRs) with corresponding 95% confidence intervals were used to compare groups. Results: In total, 1141 athletes were identified for analysis. Of these, 186 athletes (16.3%) had a history of precollegiate orthopaedic surgery. There were 261 documented intracollegiate orthopaedic surgeries in 181 athletes (15.9%). Precollegiate knee surgery was an independent predictor of orthopaedic surgery (HR, 1.85; 95% CI, 1.16-2.83) in college. When examining only surgeries resulting from acute or primary injuries, precollegiate knee surgery was an independent predictor of primary knee injury requiring surgery in college (HR, 4.45; 95% CI, 2.51-7.59). Athletes with a history of precollegiate surgery were more susceptible to subsequent surgery in their ipsilateral extremity compared with their other extremities (HR, 1.89; 95% CI, 1.03-3.53). In contrast, there was no additional risk of receiving subsequent surgery in the contralateral extremity ( P = .54). Conclusion: Precollegiate knee surgery in the Division I athlete is associated with subsequent injury requiring surgery in college. Athletes with a history of precollegiate surgery are at higher risk of subsequent surgery in their ipsilateral extremity compared with other extremities.
Concussion Incidence and Return-to-Play Time in National Basketball Association Players
Authors: Padaki Ajay S. , Cole Brian J. , Ahmad Christopher S. 
Published: March 2016

Background: Various research efforts have studied concussions in the National Football League, Major League Baseball, and the National Hockey League. However, no study has investigated the incidence and return-to-play trends in the National Basketball Association (NBA), which this study aims to do. Hypothesis: Increased media scrutiny and public awareness, in addition to the institution of a league-wide concussion protocol, may have resulted in more conservative return-to-play practices. Study Design: Descriptive epidemiology study. Methods: All concussions to NBA players that were publicly reported in the media from the beginning of the 2006 NBA season to the end of the 2014 season were included. The incidence and return-to-play statistics were generated by synthesizing information from publicly available records. Results: There were 134 publicly reported concussions to NBA players from the beginning of the 2006 season to the conclusion of the 2014 season, resulting in an average of 14.9 concussions per season. The incidence has not changed significantly during this time span. The average games missed after a concussion from 2006 to 2010 was 1.6, significantly less than the 5.0 games missed from 2011 to 2014, following the institution of the NBA concussion protocol ( P = .023). Conclusion: Although the incidence of publicly reported concussions in the NBA has not changed appreciably over the past 9 seasons, the time missed after a concussion has. While players often returned in the same game in the 2006 season, the combination of implemented policy, national coverage, medical staff awareness, and player education may have contributed to players now missing an average of 4 to 6 games after a concussion. A multitude of factors has resulted in more conservative return-to-play practices for NBA players after concussions.
Targeting and therapeutic peptides in nanomedicine for atherosclerosis
Authors: Chung Eun Ji 
Published: March 2016

Peptides in atherosclerosis nanomedicine provide structural, targeting, and therapeutic functionality and can assist in overcoming delivery barriers of traditional pharmaceuticals. Moreover, their inherent biocompatibility and biodegradability make them especially attractive as materials intended for use in vivo. In this review, an overview of nanoparticle-associated targeting and therapeutic peptides for atherosclerosis is provided, including peptides designed for cellular targets such as endothelial cells, monocytes, and macrophages as well as for plaque components such as collagen and fibrin. An emphasis is placed on recent advances in multimodal strategies and a discussion on current challenges and barriers for clinical applicability is presented.
Reducing Glucose Variability Due to Meals and Postprandial Exercise in T1DM Using Switched LPV Control
Authors: Colmegna Patricio H. , Sánchez-Peña Ricardo S. , Gondhalekar Ravi , Dassau Eyal , Doyle Francis J. 
Published: March 2016

Background: Time-varying dynamics is one of the main issues for achieving safe blood glucose control in type 1 diabetes mellitus (T1DM) patients. In addition, the typical disturbances considered for controller design are meals, which increase the glucose level, and physical activity (PA), which increases the subject’s sensitivity to insulin. In previous works the authors have applied a linear parameter-varying (LPV) control technique to manage unannounced meals. Methods: A switched LPV controller that switches between 3 LPV controllers, each with a different level of aggressiveness, is designed to further cope with both unannounced meals and postprandial PA. Thus, the proposed control strategy has a “standard” mode, an “aggressive” mode, and a “conservative” mode. The “standard” mode is designed to be applied most of the time, while the “aggressive” mode is designed to deal only with hyperglycemia situations. On the other hand, the “conservative” mode is focused on postprandial PA control. Results: An ad hoc simulator has been developed to test the proposed controller. This simulator is based on the distribution version of the UVA/Padova model and includes the effect of PA based on Schiavon.1 The test results obtained when using this simulator indicate that the proposed control law substantially reduces the risk of hypoglycemia with the conservative strategy, while the risk of hyperglycemia is scarcely affected. Conclusions: It is demonstrated that the announcement, or anticipation, of exercise is indispensable for letting a mono-hormonal artificial pancreas deal with the consequences of postprandial PA. In view of this the proposed controller allows switching into a conservative mode when notified of PA by the user.
Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227
Authors: Glass Jon , Won Minhee , Schultz Christopher J. , Brat Daniel , Bartlett Nancy L. , Suh John H. , Werner-Wasik Maria , Fisher Barbara Jean , Liepman Marcia K. , Augspurger Mark , Bokstein Felix , Bovi Joseph A. , Solhjem Matthew C. , Mehta Minesh P. 
Published: March 2016

Purpose This study investigated the treatment of primary CNS lymphoma with methotrexate, temozolomide (TMZ), and rituximab, followed by hyperfractionated whole-brain radiotherapy (hWBRT) and subsequent TMZ. The primary phase I end point was the maximum tolerated dose of TMZ. The primary phase II end point was the 2-year overall survival (OS) rate. Secondary end points were preirradiation response rates, progression-free survival (PFS), neurologic toxicities, and quality of life. Patients and Methods The phase I study increased TMZ doses from 100 to 150 to 200 mg/m2. Patients were treated with rituximab 375 mg/m2 3 days before cycle 1; methotrexate 3.5 g/m2 with leucovorin on weeks 1, 3, 5, 7, and 9; TMZ daily for 5 days on weeks 4 and 8; hWBRT 1.2 Gy twice-daily on weeks 11 to 13 (36 Gy); and TMZ 200 mg/m2 daily for 5 days every 28 days on weeks 14 to 50. Results Thirteen patients (one ineligible) were enrolled in phase I of the study. The maximum tolerated dose of TMZ was 100 mg/m2. Dose-limiting toxicities were hepatic and renal. In phase II, 53 patients were treated. Median follow-up for living eligible patients was 3.6 years, and 2-year OS and PFS were 80.8% and 63.6%, respectively. Compared with historical controls from RTOG-9310, 2-year OS and PFS were significantly improved (P = .006 and .030, respectively). In phase II, the objective response rate was 85.7%. Among patients, 66% (35 of 53) had grade 3 and 4 toxicities before hWBRT, and 45% (24 of 53) of patients experienced grade 3 and 4 toxicities attributable to post-hWBRT chemotherapy. Cognitive function and quality of life improved or stabilized after hWBRT. Conclusion This regimen is safe, with the best 2-year OS and PFS achieved in any Radiation Therapy Oncology Group primary CNS lymphoma trial. Randomized trials that incorporate this regimen are needed to determine its efficacy compared with other strategies.
Adjuvant Tamoxifen Plus Ovarian Function Suppression Versus Tamoxifen Alone in Premenopausal Women With Early Breast Cancer: Patient-Reported Outcomes in the Suppression of Ovarian Function Trial
Authors: Ribi Karin , Luo Weixiu , Bernhard Jürg , Francis Prudence A. , Burstein Harold J. , Ciruelos Eva , Bellet Meritxell , Pavesi Lorenzo , Lluch Ana , Visini Marilena , Parmar Vani , Tondini Carlo , Kerbrat Pierre , Perelló Antonia , Neven Patrick , Torres Roberto , Lombardi Davide , Puglisi Fabio , Karlsson Per , Ruhstaller Thomas , Colleoni Marco , Coates Alan S. , Goldhirsch Aron , Price Karen N. , Gelber Richard D. , Regan Meredith M. , Fleming Gini F. 
Published: March 2016

Purpose The Suppression of Ovarian Function trial showed improved disease control for tamoxifen plus ovarian function suppression (OFS) compared with tamoxifen alone for the cohort of premenopausal patients who received prior chemotherapy. We present the patient-reported outcomes. Patients and Methods The quality-of-life (QoL) analysis includes 1,722 of 2,045 premenopausal patients with hormone receptor–positive breast cancer randomly assigned to receive adjuvant treatment with 5 years of tamoxifen plus OFS or tamoxifen alone. Chemotherapy use before enrollment was optional. Patients completed a QoL form consisting of global and symptom indicators at baseline, every 6 months for 24 months, and annually during years 3 to 6. Differences in the change of QoL from baseline between the two treatments were tested at 6, 24, and 60 months with mixed models for repeated measures with and without chemotherapy and overall. Results Patients on tamoxifen plus OFS were more affected than patients on tamoxifen alone by hot flushes at 6 and 24 months, by loss of sexual interest and sleep disturbance at 6 months, and by vaginal dryness up to 60 months. Without prior chemotherapy, patients on tamoxifen alone reported more vaginal discharge over the 5 years than patients on tamoxifen plus OFS. Symptom-specific treatment differences at 6 months were less pronounced in patients with prior chemotherapy. Changes in global QoL indicators from baseline were small and similar between treatments over the whole treatment period. Conclusion Overall, OFS added to tamoxifen resulted in worse endocrine symptoms and sexual functioning during the first 2 years of treatment, with variable magnitudes of treatment differences. Short-term differences in symptom-specific QoL, treatment burden, and coping effort between treatment groups were less pronounced for patients with prior chemotherapy, the cohort that benefited most from OFS in terms of disease control.
De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility
Authors: Kawai Tomoko , Yanaka Noriyuki , Richards JoAnne S. , Shimada Masayuki 
Published: March 2016

AbstractRetinoic acid (RA) is the active form of vitamin A and is synthesized from retinol by two key enzymes, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). As the physiological precursor of RA, retinol impacts female reproductive functions and fertility. The expression of Adh1 and Adh5 as well as Aldh1a1 and Aldh1a7 are significantly increased in the ovaries of mice treated with equine chorionic gonadotropin/FSH. The RA receptor is expressed and localized in granulosa cells and is activated by endogenous RA as indicated by LacZ expression in granulosa cells of RA-responsive transgene-LacZ transgenic mice (RA reporter mice). Coinjection of the ADH inhibitor, 4-methylpyrazole, with equine chorionic gonadotropin significantly decreases the number and developmental competence of oocytes ovulated in response to human chorionic gonadotropin/LH as compared with controls. Injections of RA completely reverse the effects of the inhibitor of ovulation and oocyte development. When mice were fed a retinol-free, vitamin A-deficient diet that significantly reduced the serum levels of retinol, the expression of the LH receptor (Lhcgr) was significantly lower in the ovaries of the vitamin A-deficient mice, and injections of human chorionic gonadotropin failed to induce genes controlling ovulation. These results indicate that ovarian de novo biosynthesis of RA is required for the follicular expression of Lhcgr in granulosa cells and their ability to respond to the ovulatory LH surge.
Correlating Magnetic Exchange in Dinuclear Bis(phenolate)-Bridged Complexes: A Computational Perspective
Authors: Archana Velloth , Imamura Yutaka , Sakiyama Hiroshi , Hada Masahiko 
Published: March 2016

Abstract
Density functional theory (DFT) calculations were performed to analyse the magnetic properties of dinuclear Ni–Ni and Cu–Cu bis(phenolate)-bridged complexes with two antiferromagnetically-coupled metals. The estimated coupling constants J are −384.8 and −375.3 cm−1 for the two Cu complexes and −85.7 cm−1 for the Ni complex, which are consistent with the experimental values. Analysis of overlap integral can explain the difference in the coupling J between Ni and Cu complexes: Two dx2 − y2 orbitals of the copper complexes are located on the same plane as that of a phenolate ligand, and therefore produce the strong J coupling, whereas those of the nickel complex are tilted from the plane of phenolate ligand because of asymmetric environment around Ni atom, and produce moderate J coupling. We also examined the dependences of magnetic interaction in terms of several important geometrical parameters. The M–O–M bond angle is the key parameter for antiferro–ferromagnetic transition, which is consistent with previous studies for the other complexes. Also, increasing the M–O–O–M dihedral angle, decreasing the M–O–M bond angle and large hinge distortions on these complexes effectively enhance the ferromagnetic exchange, which is a desired condition for a better molecular magnet.