bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Room Location on UV-C Irradiance and UV-C Dosage and Antimicrobial Effect Delivered by a Mobile UV-C Light Device
Authors: Boyce John M. , Farrel Patricia A. , Towle Dana , Fekieta Renee , Aniskiewicz Michael 
Published: March 2016

OBJECTIVETo evaluate ultraviolet C (UV-C) irradiance, UV-C dosage, and antimicrobial effect achieved by a mobile continuous UV-C device.DESIGNProspective observational study.METHODSWe used 6 UV light sensors to determine UV-C irradiance (W/cm2) and UV-C dosage (µWsec/cm2) at various distances from and orientations relative to the UV-C device during 5-minute and 15-minute cycles in an ICU room and a surgical ward room. In both rooms, stainless-steel disks inoculated with methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and Clostridium difficile spores were placed next to sensors, and UV-C dosages and log10 reductions of target organisms achieved during 5-minute and 15-minute cycles were determined. Mean irradiance and dosage readings were compared using ANOVA.RESULTSMean UV-C irradiance was nearly 1.0E-03 W/cm2 in direct sight at a distance of 1.3 m (4 ft) from the device but was 1.12E-05 W/cm2 on a horizontal surface in a shaded area 3.3 m (10 ft) from the device (P<.001). Mean UV-C dosages received by UV-C sensors located at different distances and orientation relative to the device varied significantly during 5-minute cycles and during 15-minute cycles (P<.001). Log10 reductions ranged from >4 to 1–3 for MRSA, >4 to 1–2 for VRE and >4 to 0 log10 for C. difficile spores, depending on the distance from, and orientation relative to, the device with 5-minute and 15-minute cycles.CONCLUSIONUV-C irradiance, dosage, and antimicrobial effect received from a mobile UV-C device varied substantially based on location in a room relative to the UV-C device.Infect Control Hosp Epidemiol 2016;37:667–672
The “Hot Mess” of Situational Judgment Test Construct Validity and Other Issues
Authors: McDaniel Michael A. , List Sheila K. , Kepes Sven 
Published: March 2016

The construct validity of situational judgment tests (SJTs) is a “hot mess.” The suggestions of Lievens and Motowidlo (2016) concerning a strategy to make the constructs assessed by an SJT more “clear and explicit” (p. 5) are worthy of serious consideration. In this commentary, we highlight two challenges that will likely need to be addressed before one can develop SJTs with clear and explicit constructs. We also offer critiques of four positions presented by Lievens and Motowidlo that are not well supported by evidence.
Flow instabilities in the wake of a rounded square cylinder
Authors: Park Doohyun , Yang Kyung-Soo 
Published: March 2016

Instabilities in the flow past a rounded square cylinder have been numerically studied in order to clarify the effects of rounding the sharp edges of a square cylinder on the primary and secondary instabilities associated with the flow. Rounding the edges was done by inscribing a quarter circle of radius $r$ in each edge of a square cylinder of height $d$. Nine cases of rounding were considered, ranging from a square cylinder ($r/d=0$) to a circular cylinder ($r/d=0.5$) with an increment of 0.0625. Each cross-section was numerically implemented in a Cartesian grid system by using an immersed boundary method. The key parameters are the Reynolds number (Re) and the edge-radius ratio ($r/d$). For low Re, the flow is steady and symmetric with respect to the centreline. Over the first critical Reynolds number ($Re_{c1}$), the flow undergoes a Hopf bifurcation to a time-periodic flow, termed the primary instability. As Re further increases, the onset of the secondary instability of three-dimensional (3D) nature is detected beyond the second critical Reynolds number ($Re_{c2}$). Rounding the sharp edges of a square cylinder significantly affects the flow topology, leading to noticeable changes in both instabilities. By employing the Stuart–Landau equation, we investigated the criticality of the primary instability depending upon $r/d$. The onset of the 3D secondary instability was detected by using Floquet stability analysis. The temporal and spatial characteristics of the dominant modes (A, B, QP) were described. The neutral stability curves of each mode were computed depending upon $r/d$.
Simulation of three-dimensional rapid free-surface granular flow past different types of obstructions using the SPH method
Authors: ABDELRAZEK AHMED M. , KIMURA ICHIRO , SHIMIZU YASUYUKI 
Published: March 2016

ABSTRACTIn nature, when hazardous geophysical granular flows (e.g. a snow avalanche) impact on an obstacle as they stream down a slope, rapid changes in flow depth, direction and velocity will occur. It is important to understand how granular material flows around such obstacles in order to enhance the design of defense structures. In this study, a three dimensional (3-D) Smoothed Particle Hydrodynamics (SPH) model is developed to simulate granular flow past different types of obstacles. The elastic–perfectly plastic model with implementation of the Mohr–Coulomb failure criterion is applied to simulate the material behavior, which describes the stress states of soil in the plastic flow regime. The model was validated by simulating the collapse of a 3-D column of sand with two different aspect ratios; the results showed that the SPH method is capable of simulating granular flow. The model is then applied to simulate the gravity-driven granular flow down an inclined surface obstructed by a group of columns with different spacing, a circular cylinder and a tetrahedral wedge. The numerical results are then compared with experimental results and two different numerical solutions. The good agreements obtained from these comparisons demonstrate that the SPH method may be a powerful method for simulating granular flow and can be extended to design protective structures.
Neurophysiological investigations for the diagnosis of non-epileptic attack disorder in neuropsychiatry services: from safety standards to improved effectiveness
Authors: Cavanna Andrea E. , Seri Stefano 
Published: March 2016

ObjectiveThe discipline of clinical neuropsychiatry currently provides specialised services for a number of conditions that cross the traditional boundaries of neurology and psychiatry, including non-epileptic attack disorder. Neurophysiological investigations have an important role within neuropsychiatry services, with video-electroencephalography (EEG) telemetry being the gold standard investigation for the differential diagnosis between epileptic seizures and non-epileptic attacks. This article reviews existing evidence on best practices for neurophysiology investigations, with focus on safety measures for video-EEG telemetry.MethodsWe conducted a systematic literature review using the PubMed database in order to identify the scientific literature on the best practices when using neurophysiological investigations in patients with suspected epileptic seizures or non-epileptic attacks.ResultsSpecific measures need to be implemented for video-EEG telemetry to be safely and effectively carried out by neuropsychiatry services. A confirmed diagnosis of non-epileptic attack disorder following video-EEG telemetry carried out within neuropsychiatry units has the inherent advantage of allowing diagnosis communication and implementation of treatment strategies in a timely fashion, potentially improving clinical outcomes and cost-effectiveness significantly.ConclusionThe identified recommendations set the stage for the development of standardised guidelines to enable neuropsychiatry services to implement streamlined and evidence-based care pathways.
Homophily, influence and the decay of segregation in self-organizing networks
Authors: HENRY ADAM DOUGLAS , MITSCHE DIETER , PRAŁAT PAWEŁ 
Published: March 2016

AbstractWe study the persistence of network segregation in networks characterized by the co-evolution of vertex attributes and link structures, in particular where individual vertices form linkages on the basis of similarity with other network vertices (homophily), and where vertex attributes diffuse across linkages, making connected vertices more similar over time (influence). A general mathematical model of these processes is used to examine the relative influence of homophily and influence in the maintenance and decay of network segregation in self-organizing networks. While prior work has shown that homophily is capable of producing strong network segregation when attributes are fixed, we show that adding even minute levels of influence is sufficient to overcome the tendency towards segregation even in the presence of relatively strong homophily processes. This result is proven mathematically for all large networks and illustrated through a series of computational simulations that account for additional network evolution processes. This research contributes to a better theoretical understanding of the conditions under which network segregation and related phenomenon—such as community structure—may emerge, which has implications for the design of interventions that may promote more efficient network structures.
A high-fat, high-glycaemic index, low-fibre dietary pattern is prospectively associated with type 2 diabetes in a British birth cohort
Authors: Pastorino Silvia , Richards Marcus , Pierce Mary , Ambrosini Gina L. 
Published: March 2016

AbstractThe combined association of dietary fat, glycaemic index (GI) and fibre with type 2 diabetes has rarely been investigated. The objective was to examine the relationship between a high-fat, high-GI, low-fibre dietary pattern across adult life and type 2 diabetes risk using reduced rank regression. Data were from the MRC National Survey of Health and Development. Repeated measures of dietary intake estimated using 5-d diet diaries were available at the age of 36, 43 and 53 years for 1180 study members. Associations between dietary pattern scores at each age, as well as longitudinal changes in dietary pattern z-scores, and type 2 diabetes incidence (n 106) from 53 to 60–64 years were analysed. The high-fat, high-GI, low-fibre dietary pattern was characterised by low intakes of fruit, vegetables, low-fat dairy products and whole-grain cereals, and high intakes of white bread, fried potatoes, processed meat and animal fats. There was an increasing trend in OR for type 2 diabetes with increasing quintile of dietary pattern z-scores at the age of 43 years among women but not among men. Women in the highest z-score quintile at the age of 43 years had an OR for type 2 diabetes of 5·45 (95 % CI 2·01, 14·79). Long-term increases in this dietary pattern, independently of BMI and waist circumference, were also detrimental among women: for each 1 sd unit increase in dietary pattern z-score between 36 and 53 years, the OR for type 2 diabetes was 1·67 (95 % CI 1·20, 2·43) independently of changes in BMI and waist circumference in the same periods. A high-fat, high-GI, low-fibre dietary pattern was associated with increased type 2 diabetes risk in middle-aged British women but not in men.
The relationship between asymmetry, size and unusual venation in honey bees (Apis mellifera)
Authors: Łopuch S. , Tofilski A. 
Published: March 2016

AbstractDespite the fact that symmetry is common in nature, it is rarely perfect. Because there is a wide range of phenotypes which differs from the average one, the asymmetry should increase along with deviation. Therefore, the aim of this study was to assess the level of asymmetry in normal individuals as well as in phenodeviants categorized as minor or major based on abnormalities in forewing venation in honey bees. Shape fluctuating asymmetry (FA) was lower in normal individuals and minor phenodeviants compared with major phenodeviants, whereas the former two categories were comparable in drones. In workers and queens, there were not significant differences in FA shape between categories. FA size was significantly lower in normal individuals compared with major phenodeviant drones and higher compared with minor phenodeviant workers. In queens, there were no significant differences between categories. The correlation between FA shape and FA size was significantly positive in drones, and insignificant in workers and queens. Moreover, a considerable level of directional asymmetry was found as the right wing was constantly bigger than the left one. Surprisingly, normal individuals were significantly smaller than minor phenodeviants in queens and drones, and they were comparable with major phenodeviants in all castes. The correlation between wing size and wing asymmetry was negative, indicating that smaller individuals were more asymmetrical. The high proportion of phenodeviants in drones compared with workers and queens confirmed their large variability. Thus, the results of the present study showed that minor phenodeviants were not always intermediate as might have been expected.
Private Equity Firms’ Reputational Concerns and the Costs of Debt Financing
Authors: Huang Rongbing , Ritter Jay R. , Zhang Donghang 
Published: March 2016

AbstractA popular view is that private equity (PE) firms tend to expropriate other stakeholders of their portfolio companies. Bonds offered during 1992–2011 by companies after their initial public offerings (IPOs) do not reflect this view. We find that yield spreads on bonds offered by PE-backed companies are, on average, 70 basis points lower, holding other things constant. We also find that PE-backed companies have more conservative investment and dividend policies after bond offerings compared with non-PE-backed companies. These results suggest that PE firms’ reputational concerns dominate their wealth expropriation incentives and help their portfolio companies reduce the costs of debt.
CEO Narcissism and the Takeover Process: From Private Initiation to Deal Completion
Authors: Aktas Nihat , de Bodt Eric , Bollaert Helen , Roll Richard 
Published: March 2016

AbstractChief executive officer (CEO) narcissism affects the takeover process. Acquirer shareholders react less favorably to a takeover announcement when the target CEO is more narcissistic. Narcissistic acquiring CEOs negotiate faster. They are also marginally more likely to initiate deals. Acquirer CEO narcissism and target CEO narcissism are associated with a lower probability of deal completion and reduce the likelihood that the target CEO will be employed by the merged firm. Our findings highlight the importance of both acquirer and target CEO psychological characteristics throughout the takeover process.
Two decades of change in state, pressure and conservation responses in the coastal forest biodiversity hotspot of Tanzania
Authors: Burgess Neil D. , Malugu Isaac , Sumbi Peter , Kashindye Almas , Kijazi Adam , Tabor Karyn , Mbilinyi Boniface , Kashaigili Japhet , Wright Timothy Maxwell , Gereau Roy E. , Coad Lauren , Knights Kathryn , Carr Jamie , Ahrends Antje , Newham Rebecca L. 
Published: March 2016

AbstractWe present an analysis of changes of state, pressures and conservation responses over 20 years in the Tanzanian portion of the Coastal Forests of Eastern Africa biodiversity hotspot. Baseline data collected during 1989–1995 are compared with data from a synthesis of recently published papers and reports and new field work carried out across the region during 2010–2014. We show that biodiversity endemism values are largely unchanged, although two new species (amphibian and mammal) have been named and two extremely rare tree species have been relocated. However, forest habitat continues to be lost and degraded, largely as a result of agricultural expansion, charcoal production to supply cities with cooking fuel, logging for timber and cutting of wood for firewood and building poles. Habitat loss is linked to an increase in the number of species threatened over time. The government-managed forest reserve network has expanded slightly but has low effectiveness. Three forest reserves have been upgraded to National Parks and Nature Reserves, which have stricter protection and more effective enforcement. There has also been rapid development of village-owned forest reserves, with more than 140 now existing; although usually small, they are an important addition to the areas being managed for sustainable resource use, and also provide tangible benefits to local people. Human-use pressures remain intense in many areas, and combined with emerging pressures from mining, gas and oil exploration, many endemic species remain threatened with extinction.
Protein dynamics and function from solution state NMR spectroscopy
Authors: Kovermann Michael , Rogne Per , Wolf-Watz Magnus 
Published: March 2016

AbstractIt is well-established that dynamics are central to protein function; their importance is implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of binding cooperativity, which was originally proposed in 1965. Nowadays the concept of protein dynamics is formulated in terms of the energy landscape theory, which can be used to understand protein folding and conformational changes in proteins. Because protein dynamics are so important, a key to understanding protein function at the molecular level is to design experiments that allow their quantitative analysis. Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited for this purpose because major advances in theory, hardware, and experimental methods have made it possible to characterize protein dynamics at an unprecedented level of detail. Unique features of NMR include the ability to quantify dynamics (i) under equilibrium conditions without external perturbations, (ii) using many probes simultaneously, and (iii) over large time intervals. Here we review NMR techniques for quantifying protein dynamics on fast (ps-ns), slow (μs-ms), and very slow (s-min) time scales. These techniques are discussed with reference to some major discoveries in protein science that have been made possible by NMR spectroscopy.
Human evolutionary history and contemporary evolutionary theory provide insight when assessing cultural group selection
Authors: Fuentes Agustin , Kissel Marc 
Published: March 2016

AbstractRicherson et al. provide a much needed roadmap for assessing cultural group selection (CGS) theory and for applying it to understanding variation between contemporary human groups. However, the current proposal lacks connection to relevant evidence from the human evolutionary record and requires a better integration with contemporary evolutionary theory. The article also misapplies the Fst statistic.
A regression model for pooled data in a two-stage survey under informative sampling with application for detecting and estimating the presence of transgenic corn
Authors: Montesinos-López Osval A. , Eskridge Kent , Montesinos-López Abelardo , Crossa José , Cortés-Cruz Moises , Wang Dong 
Published: March 2016

AbstractGroup-testing regression methods are effective for estimating and classifying binary responses and can substantially reduce the number of required diagnostic tests. However, there is no appropriate methodology when the sampling process is complex and informative. In these cases, researchers often ignore stratification and weights that can severely bias the estimates of the population parameters. In this paper, we develop group-testing regression models for analysing two-stage surveys with unequal selection probabilities and informative sampling. Weights are incorporated into the likelihood function using the pseudo-likelihood approach. A simulation study demonstrates that the proposed model reduces the bias in estimation considerably compared to other methods that ignore the weights. Finally, we apply the model for estimating the presence of transgenic corn in Mexico and we give the SAS code used for the analysis.
Daily lives of residents with dementia in nursing homes: development of the Maastricht electronic daily life observation tool
Authors: de Boer B. , Beerens H.C. , Zwakhalen S.M.G. , Tan F.E.S. , Hamers J.P.H. , Verbeek H. 
Published: March 2016

ABSTRACTBackground:Daily life is a dynamic and multidimensional concept, for which appropriate assessment tools are lacking. This study describes the development of the Maastricht Electronic Daily Life Observation tool (MEDLO-tool), a freely accessible, easy to use, electronic observation tool to assess relevant daily life aspects for nursing home residents with dementia.Methods:(1) Determining relevant aspects of daily life for nursing home residents with dementia based on a literature search and expert interviews; (2) pilot testing observation procedures and operationalizations of the aspects of daily life; and (3) exploring inter-rater reliability and feasibility of the tool in a nursing home facility with 16 residents (56% female, mean age: 77).Results:The following aspects of daily life are assessed with the MEDLO-tool: (1) activity (activity performed by resident, engagement in this activity, and the degree of physical effort); (2) physical environment (location of the resident and interaction with the physical environment); (3) social interaction (the level and type of social interaction, and with whom this social interaction took place); and (4) emotional well-being (mood and agitation). Each aspect of daily life is observed and scored using standardized scoring options. Agreement on the aspects is high with an average absolute agreement of 86%. Users of the MEDLO-tool indicated that it was feasible in practice and contained clear operationalization of the aspects of daily life.Conclusions:The MEDLO-tool is a promising tool to gain real time insight into the aspects of the daily lives of nursing home residents with dementia.
Assessment of inattention in the context of delirium screening: one size does not fit all!
Authors: Voyer Philippe , Champoux Nathalie , Desrosiers Johanne , Landreville Philippe , Monette Johanne , Savoie Maryse , Carmichael Pierre-Hugues , Richard Sylvie , Bédard Annick 
Published: March 2016

ABSTRACTBackground:Despite its high prevalence and deleterious consequences, delirium often goes undetected in older hospitalized patients and long-term care (LTC) residents. Inattention is a core symptom of this syndrome. The aim of this study was to explore the usefulness of ten simple and objective attention tests that would enable efficient delirium screening among this population.Methods:This was a secondary analysis (n = 191) of a validation study conducted in one acute care hospital (ACH) and one LTC facility among older adults with, or without, cognitive impairment. The attention test tasks (n = 10) were drawn from the Concentration subscale the Hierarchic Dementia Scale (HDS). Delirium was defined as meeting the criteria for DSM-5 delirium. The Confusion Assessment Method (CAM) was used to determine the presence of delirium symptoms.Results:The Months of the Year Backward (MOTYB) test, which 57% of participants completed successfully, showed the best balance between sensitivity and specificity (82.6%; 95% CI [61.2–95.0], and 62.5%; 95% CI [54.7–69.8] respectively) for the entire group. Subgroup analyses revealed that no test had both sensitivity and specificity over 50% in participants with cognitive impairment indicated in their medical chart.Conclusions:Our results revealed that these tests varied greatly in performance and none can be earmarked to become a single-item screening tool for delirium among older patients and residents with, or without, cognitive impairment. The presence of premorbid cognitive impairment may necessitate more extensive assessments of delirium, especially when a change in general status or mental state is observed.