bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual volume‐based 3D gamma indices for pretreatment VMAT QA
Authors: Yi Jinling , Han Ce , Zheng Xiaomin , Zhou Yongqiang , Deng Zhenxiang , Xie Congying , Jin Xiance , Jin Fu 
Published: March 2017

AbstractAlthough gamma analysis is still a widely accepted quantitative tool to analyze and report patient‐specific QA for intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc therapy (VMAT), the correlation between the 2D percentage gamma passing rate (%GP), and the clinical dosimetric difference for IMRT and VMAT has been questioned. The purpose of this study was to investigate the feasibility of individual volume‐based 3D gamma indices for pretreatment VMAT QA. Percentage dosimetric errors (%DE) of dose‐volume histogram metrics (includes target volumes and organ at risks) between the treatment planning system and QA‐reconstructed dose distribution, %GPs for individual volume and global gamma indices, as well their correlations and sensitivities were investigated for one‐ and two‐arc VMAT plans. The %GPs of individual volumes had a higher percent of correlation with individual 15 %DE metrics compared with global %GPs. For two‐arc VMAT at 2%/2 mm, 3%/3 mm, and 4%/4 mm criteria, individual volume %GPs were correlated with 9, 12, and 9 out of 15 %DE metrics, while global %GPs were correlated with only 2 out of 15 %DE metrics, respectively. For one‐arc VMAT at 2%/2 mm, 3%/3 mm, and 4%/4 mm criteria, individual volume %GPs were correlated with 18, 16, and 13 out of 23 %DE metrics, and global %GPs were correlated with 19, 12, and 1 out 23 %DE metrics, respectively. The area under curves (AUC) of individual volume %GPs were higher than those of global %GPs for two‐arc VMAT plans, but with mixed results for one‐arc VMAT plans. In a conclusion, the idea of individual volume %GP was created and investigated to better serve for VMAT QA and individual volume‐based %GP had a higher percent of correlation with DVH 15 %DE metrics compared with global %GP for both one‐ and two‐arc VMAT plans.
Comparison of the Sensitivity to Change of the 36‐Item Short Form Health Survey and the Lupus Quality of Life Measure Using Various Definitions of Minimum Clinically Important Differences in Patients With Active Systemic Lupus Erythematosus
Authors: Nantes Stephanie G. , Strand Vibeke , Su Jiandong , Touma Zahi 
Published: March 2017

ObjectiveThe Medical Outcomes Study Short Form 36 (SF‐36) and Lupus Quality of Life (LupusQoL) are health‐related quality of life questionnaires used in systemic lupus erythematosus (SLE). We first determined the hypothesis‐testing construct validity of the SF‐36 and LupusQoL against disease activity in patients with active SLE and then compared the sensitivity to change of SF‐36 and LupusQoL domains according to different definitions of minimum clinically important differences (MCIDs) for improvement and worsening in the current cohort.MethodsSeventy‐eight clinically active SLE patients concurrently completed both questionnaires at their baseline and followup visits. Questionnaire domain scores were correlated with the SLE Disease Activity Index 2000 (SLEDAI‐2K) and evaluated for floor/ceiling effects. The sensitivity to change of domains in each questionnaire was analyzed first, according to the various MCID definitions and, second, by clinically meaningful changes in disease activity. The magnitudes of change in each domain score between the baseline and followup visit were evaluated using standardized response means.ResultsIn the 78 patients, the mean ± SD SLEDAI‐2K scores were 9.7 ± 4.8 at baseline and 8.8 ± 5.1 at followup. SF‐36/LupusQoL domain scores did not correlate with disease activity. The SF‐36 showed floor effects, and ceiling effects were evident in both questionnaires. All domains of both questionnaires showed sensitivity to change over time. Specific domains that reflected worsening or improvement differed according to differing MCID definitions.ConclusionIn SLE patients with active disease, both the SF‐36 and LupusQoL are sensitive to change, reflecting both improvement and worsening. More importantly, the LupusQoL SLE‐specific domains (planning, burden to others, body image, and intimate relationships) were largely responsive to change.
Amine‐Triggered 6π‐Electrocyclization–Aromatization Cascade of Ynedienamines
Authors: Li Xijian , Yu Huidong , Huang Yong 
Published: March 2017

AbstractAn unprecedented 6π‐electrocyclization–aromatization cascade reaction of ynedienamines is described. The electron‐rich ynedienamine is converted by γ‐protonation to an electrophilic allenyl iminium species which is susceptible to amine addition generating a highly electron‐rich triene intermediate. The 6π‐electrocyclization is accelerated by three electron‐donating substituents in a captodative manner. Subsequent redox‐neutral aromatization allows the direct synthesis of 1,3‐diaminobenzenes from readily available ynedienamines.magnified image
Intramolecular Direct Arylation of 1,3‐Diketone‐Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives
Authors: Muimhneacháin Eoin Ó , Pardo Leticia M. , Bateman Lorraine M. , Rao Khandavilli U. B. , Lawrence Simon E. , McGlacken Gerard P. 
Published: March 2017

AbstractA synthesis of tricyclic oxoisochromene derivatives via an intramolecular direct arylation of cycloalkyl‐1,3‐diketone‐derived α,β‐unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd).magnified image
N,N′‐Dioxide–Lanthanum(III)‐Catalyzed Asymmetric Cyclopropanation of 2‐Cyano‐3‐arylacrylates with 2‐Bromomalonates
Authors: Zhang Yuheng , Lin Lili , Chen Yushuang , Liu Xiaohua , Feng Xiaoming 
Published: March 2017

AbstractAn efficient N,N′‐dioxide–lanthanum(III) complex catalytic system has been developed for the diastereo‐ and enantioselective Michael‐initiated ring‐closure (MIRC) reaction of 2‐cyano‐3‐arylacrylates with 2‐bromomalonates. Various chiral cyclopropanes with multiple substitutions were obtained in high yields (up to 93%) with excellent dr (>95:5 dr) and good ee values (up to 91% ee). The catalytic system also worked for the tandem halogenation/asymmetric MIRC reaction of α,β‐unsaturated nitriles, malonates and NBS. Besides, a possible catalytic model has been proposed to explain the origin of the stereoselectivity.magnified image
Isocyanid‐Komplexe von Cr0, Mo0 und W0 als Leuchtstoffe und Photosensibilisatoren mit langlebigen angeregten Zuständen
Authors: Büldt Laura A. , Wenger Oliver S. 
Published: March 2017

Abstractd6‐Metallkomplexe der Gruppe 6 mit Arylisocyanid‐Liganden sind aus in der Erde reichlich vorhandenen Elementen aufgebaute Alternativen zu photoaktiven Komplexen edler Metalle wie RuII, ReI, OsII oder IrIII. Einige dieser Komplexe haben langlebige angeregte 3MLCT‐Zustände, die Lumineszenz mit guten Quantenausbeuten mit Lebensdauern im Bereich von Nano‐ bis Mikrosekunden vereinbaren und überdies stark reduzierend sind. Kürzlich erfolgte Studien zeigten, dass Cr0‐, Mo0‐ und W0‐Arylisocyanide großes Anwendungspotential in Leuchtvorrichtungen, in der Photoredoxkatalyse und in Farbstoff‐sensibilisierten Solarzellen haben.
Effect of cellulose triacetate membrane thickness on forward‐osmosis performance and application for spent electroless nickel plating baths
Authors: Chen Gui‐E , Sun Wei‐Guang , Wu Qiong , Kong Ya‐Fang , Xu Zhen‐Liang , Xu Sun‐Jie , Zheng Xiao‐Peng 
Published: March 2017

ABSTRACTCellulose triacetate (CTA) forward‐osmosis (FO) membranes were prepared via the phase inversion method. The influence of thickness on the performance and morphology of CTA FO membranes was discussed in detail. When the thickness of the membrane was 50.0 ± 0.5 μm (CTA4), the prototype CTA membranes displayed a water flux of 20.2 L m−2 h−1 and a reverse salt transport of 14.6 g m−2 h−1 using 1 mol/L NaCl as the draw solution and deionized water as the feed solution during the FO process at 25 °C. In addition, the high‐performance CTA4 FO membranes have been used to process spent electroless nickel plating baths where the water flux could reach 13 L m−2 h−1 and NiSO4·6H2O crystals occurred in the feed solution of the spent electroless nickel plating baths. The recovery rates of NiSO4·6H2O and water from the spent electroless nickel plating baths were 44.54% and 53.53%, respectively. This study focused on improving membrane design for the FO process and finding a new method of waste liquor or wastewater treatment. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45049.
Synthesis of Mixed Objective Output Feedback Robust Model Predictive Control
Authors: Jiang Wei , Wang Hongli , Lu Jinghui , Qin Weiwei , Cai Guangbin 
Published: March 2017

AbstractAiming at the constrained polytopic uncertain system with energy‐bounded disturbance and unmeasurable states, a novel synthesis scheme to design the output feedback robust model predictive control(MPC)is put forward by using mixed H2/H∞ design approach. The proposed scheme involves an offline design of a robust state observer using linear matrix inequalities(LMIs)and an online output feedback robust MPC algorithm using the estimated states in which the desired mixed objective robust output feedback controllers are cast into efficiently tractable LMI‐based convex optimization problems. In addition, the closed‐loop stability and the recursive feasibility of the proposed robust MPC are guaranteed through an appropriate reformulation of the estimation error bound (EEB). A numerical example subject to input constraints illustrates the effectiveness of the proposed controller.
Urbane Sicherheit bei Explosionen – Schutz durch Bepflanzung
Authors: Gebbeken Norbert 
Published: March 2017

AbstractDie Absicherung urbaner Räume vor terroristischen Gefahren erfordert neue Lösungen des baulichen Schutzes, die nicht als solche wahrgenommen werden. Dazu gehören Elemente der Stadtmöblierung und der Landschaftsarchitektur. Dieser Artikel beschreibt numerische und experimentelle Untersuchungen zur Schutzwirkung von Pflanzen bei Explosionsdruckwellen. Es zeigt sich, dass Pflanzen mit bestimmten Eigenschaften den Explosionsdruck um bis zu 60 % abmindern. Diese ersten Untersuchungen werfen jedoch auch einige Fragen auf, die es mithilfe weiterer Forschungsarbeiten zu beantworten gilt.
Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer's disease
Authors: Crespo M. Carmen , Tomé‐Carneiro Joao , Pintado Cristina , Dávalos Alberto , Visioli Francesco , Burgos‐Ramos Emma 
Published: March 2017

AbstractRecent epidemiological evidence demonstrated that diabetes is a risk factor for AD onset and development. Indeed, meta‐analyses of longitudinal epidemiologic studies show that diabetes increases AD risk by 50–100%, being insulin resistance (IR) the main binding link between diabetes and AD. Astrocytes are the foremost cerebral macroglial cells and are responsible for converting glucose into lactate and transfer it to neurons that use it as fuel, but Aβ(1‐42) impairs insulin signaling and glycogen storage. Recent prospective studies showed that the Mediterranean diet is associated with lower incidence of AD. We hypothesized that hydroxytyrosol (HT, the preeminent polyphenol of olives and olive oil) could exert beneficial effects on IR associated with AD and investigated it mechanisms of action in an astrocytic model of AD. The astrocytic cell line C6 was exposed to Aβ(25‐35) and co‐incubated with HT for different periods. After treatment with Aβ(25‐35), astrocytes' viability was significantly decreased as compared with controls; however, both pre‐ and post‐treatment with HT prevented this effect. Mechanistically, we found that the preventive role of HT on Aβ(25‐35)‐ induced cytotoxicity in astrocytes is moderated by an increased HT‐induced activation of Akt, which is mediated by the insulin signaling pathway. In addition, we report that HT prevented the pronounced activation of mTOR, thereby restoring proper insulin signaling. In conclusion, we demonstrate that HT protects Aβ(25‐35)‐treated astrocytes by improving insulin sensitivity and restoring proper insulin‐signaling. These data provide some mechanistic insight on the observed inverse association between olive oil consumption and prevalence of cognitive impairment. © 2017 BioFactors, 43(4):540–548, 2017
Clinical implications of serum N‐glycan profiling as a diagnostic and prognostic biomarker in germ‐cell tumors
Authors: Narita Takuma , Hatakeyama Shingo , Yoneyama Tohru , Narita Shintaro , Yamashita Shinichi , Mitsuzuka Koji , Sakurai Toshihiko , Kawamura Sadafumi , Tochigi Tatsuo , Takahashi Ippei , Nakaji Shigeyuki , Tobisawa Yuki , Yamamoto Hayato , Koie Takuya , Tsuchiya Norihiko , Habuchi Tomonori , Arai Yoichi , Ohyama Chikara 
Published: March 2017

AbstractSerum biomarker monitoring is essential for management of germ‐cell tumors (GCT). However, not all GCT are positive for conventional tumor markers. We examined whether serum N‐glycan‐based biomarkers can be applied for detection and prognosis in patients with GCT. We performed a comprehensive N‐glycan structural analysis of sera from 54 untreated GCT patients and 103 age‐adjusted healthy volunteers using glycoblotting methods and mass spectrometry. Candidate N‐glycans were selected from those with the highest association; cutoff concentration values were established, and an N‐glycan score was created based on the number of positive N‐glycans present. The validity of this score for diagnosis and prognosis was analyzed using a receiver operating characteristic (ROC) curve. We identified five candidate N‐glycans significantly associated with GCT patients. The accuracy of the N‐glycan score for GCT was significant with an area‐under‐the‐curve (AUC) value of 0.87. Diagnostically, the N‐glycan score detected 10 of 12 (83%) patients with negative conventional tumor markers. Prognostically, the N‐glycan score comprised four candidate N‐glycans. The predictive value of the prognostic N‐glycan score was significant, with an AUC value of 0.89. A high value prognostic N‐glycan score was significantly associated with poor prognosis. Finally, to identify a potential carrier protein, immunoglobulin (Ig) fractions of sera were subjected to N‐glycan analysis and compared to whole sera. Candidate N‐glycans in Ig‐fractions were significantly decreased; therefore, the carrier protein for candidate N‐glycans is likely not an immunoglobulin. In summary, our newly developed N‐glycan score seems to be a practical diagnostic and prognostic method for GCT.
Tobacco use and outcome in radical prostatectomy patients
Authors: Curtis Alexandra , Ondracek Rochelle Payne , Murekeyisoni Christine , Kauffman Eric , Mohler James , Marshall James 
Published: March 2017

AbstractCigarette smoking has been consistently associated with increased risk of overall mortality, but the importance of smoking for patients with prostate cancer (CaP) who are candidates for curative radical prostatectomy (RP) has received less attention. This retrospectively designed cohort study investigated the association of smoking history at RP with subsequent CaP treatment outcomes and overall mortality. A total of 1981 patients who underwent RP at Roswell Park Cancer Institute (RPCI) between 1993 and 2014 were studied. Smoking history was considered as a risk factor for overall mortality as well as for currently accepted CaP treatment outcomes (biochemical failure, treatment failure, distant metastasis, and disease‐specific mortality). The associations of smoking status with these outcomes were tested by Cox proportional hazard analyses. A total of 153 (8%) patients died during follow‐up. Current smoking at diagnosis was a statistically significant predictor of overall mortality after RP (current smokers vs. former and never smokers, hazards ratio 2.07, 95% confidence interval [CI]: 1.36–3.14). This association persisted for overall mortality at 3, 5, and 10 years (odds ratios 2.07 [95% CI: 1.36–3.15], 2.05 [95% CI: 1.35–3.12], and 1.8 [95% CI: 1.18–2.74], respectively). Smoking was not associated with biochemical failure, treatment failure, distant metastasis, or CaP‐specific mortality, and the association of smoking with overall mortality did not appear to be functionally related to treatment or biochemical failure, or to distant metastasis. Smoking is a non‐negligible risk factor for death among CaP patients who undergo RP; patients who smoke are far more likely to die of causes other than CaP.
Trend analysis and survival of primary gallbladder cancer in the United States: a 1973–2009 population‐based study
Authors: Rahman Rubayat , Simoes Eduardo J. , Schmaltz Chester , Jackson Christian S. , Ibdah Jamal A. 
Published: March 2017

AbstractPrimary gallbladder cancer is an aggressive and uncommon cancer with poor outcomes. Our study examines epidemiology, trend, and survival of gallbladder cancer in the United States from 1973 to 2009. We utilized the Surveillance Epidemiology and End Results database (SEER). Frequency and rate analyses on demographics, stage, and survival were compared among non‐Hispanic whites, Hispanics, African American, and Asian/Pacific Islanders. A total of 18,124 cases were reported in SEER from 1973 to 2009 comprising 1.4% of all reported gastrointestinal cancers. Gallbladder cancer was more common in females than males (71 vs. 29%, respectively). The age‐adjusted incidence rate was 1.4 per 100,000, significantly higher in females than males (1.7 vs. 1.0). Trend analysis showed that the incidence rate has been decreasing over the last three decades for males. However, among females, the incidence rate had decreased from 1973 to mid‐90s but has remained stable since then. Trend analysis for stage at diagnosis showed that the proportion of late‐stage cases has been increasing significantly since 2001 after a decreasing pattern since 1973. Survival has improved considerably over time, and survival is better in females than males and in Asian/Pacific Islanders than other racial groups. The highest survival was in patients who received both surgery and radiation. Trend analysis revealed a recent increase of the incidence of late‐stage gallbladder cancer. Highest survival was associated with receiving both surgery and radiation.
Transcatheter aortic valve implantation with the self‐expandable venus A‐Valve and CoreValve devices: Preliminary Experiences in China
Authors: Liao Yan‐Biao , Zhao Zhen‐Gang , Wei Xin , Xu Yuan‐Ning , Zuo Zhi‐Liang , Li Yi‐jian , Zheng Ming‐Xia , Feng Yuan , Chen Mao 
Published: March 2017

BackgroundTranscatheter aortic valve implantation (TAVI) has been demonstrated to be an effective alternative to surgical aortic valve replacement (SAVR) in patients with aortic stenosis who are deemed high risk or inoperable. Currently, TAVI procedures in China mostly make use of the domestic Venus A‐Valve and the CoreValve; however, there is no data on their comparative performance.MethodsConsecutive patients undergoing TAVI with the aforementioned devices were included. The outcomes were reported according to the Valve Academic Research Consortium‐2 (VARC) definitions.ResultsA total of 54 TAVI procedures were performed, 27 with the CoreValve and the other 27 with the Venus A‐Valve. An additional valve was required in 4 (14.8%) and 3 (11.1%) patients, and the VARC‐2 device success rates were 81.5 and 85.2%, respectively. The incidences of common complications were similar, except for the significantly less frequent pacemaker insertion in the Venus A‐Valve group (7.4 vs. 37.0%, P = 0.03). Within 30 days, 2 (3.7%) patients died, 1 in each group, and both had a bicuspid aortic valve (BAV). No other serious complications, such as annular rupture, coronary obstruction and aortic dissection, occurred in the 32 BAV patients treated with the Venus A‐Valve (14) or the CoreValve (18). After 2‐years of follow‐up, there was no significant difference between CoreValve group and Venus‐A group (11.1 vs. 7.4%, P = 0.64).ConclusionTAVI with the domestic Venus A‐Valve is feasible, safe, and can produce favorable short‐term outcomes comparable to those with the CoreValve in inoperable or high‐risk patients with tricuspid and bicuspid aortic valve stenosis. © 2017 Wiley Periodicals, Inc.
Oxidative Transformations of Biosourced Alcohols Catalyzed by Earth‐Abundant Transition Metals
Authors: Nguyen Duc Hanh , Morin Yohann , Zhang Lei , Trivelli Xavier , Capet Frédéric , Paul Sébastien , Desset Simon , Dumeignil Franck , Gauvin Régis M. 
Published: March 2017

AbstractThe catalytic acceptorless dehydrogenative oxidation of biosourced alcohols into carboxylic acid salts was achieved using earth‐abundant Fe and Mn complexes that feature aliphatic PNP pincer ligands in good to excellent yields. The Fe derivatives were characterized by using 57Fe NMR spectroscopy. Mn pincer catalysts are catalytically more efficient than their Fe counterparts thanks to their robustness under basic conditions. Attempts to generate aldehydes from alcohols were not successful using the Fe and Mn species, but a commercially available Ru analogue achieves this transformation selectively under very mild conditions in the presence of a large excess of acetone as a hydrogen acceptor.
Attracting Enantiomers: Chiral Analytes That Are Simultaneously Shift Reagents Allow Rapid Screening of Enantiomeric Ratios by NMR Spectroscopy
Authors: Storch Golo , Haas Maren , Trapp Oliver 
Published: March 2017

AbstractThe rapid and direct determination of enantiomeric ratios is of increasing interest due to the significantly reduced effort compared to chromatographic methods and the large number of analytes, for instance in enantioselective catalysis. Current strategies include colorimetric assays, (a)chiral solvating reagents for NMR spectroscopy and metal complexes for CD sensing. We report the determination of enantiomeric ratios based on the self‐induced diastereomeric anisochronism (SIDA) effect. Alanine derivatives that represent chiral products of enantioselective catalysis, such as the well‐established hydrogenation of dehydroamino acids, were investigated. The SIDA effect was significantly enhanced by attachment of 3,5‐dinitrobenzoyl π–π interactions sites. This simple modification enabled simultaneous determination of enantiomeric ratios and conversions by NMR spectroscopy.
Dinuclear Complexes Formed by Hydrogen Bonds: Synthesis, Structure and Magnetic and Electrochemical Properties
Authors: Granelli Matteo , Downward Alan M. , Huber Robin , Guénée Laure , Besnard Céline , Krämer Karl W. , Decurtins Silvio , Liu Shi‐Xia , Thompson Laurence K. , Williams Alan F. 
Published: March 2017

AbstractThe synthesis is reported of a series of homo‐ and hetero‐dinuclear octahedral complexes of the ligand 1, 1,2‐bis(1‐methyl‐benzimidazol‐2‐yl) ethanol, where the two metal centres are linked by hydrogen bonds between coordinated alcohols and coordinated alkoxides. Homonuclear divalent MIIMII, mixed‐valent MIIMIII and heteronuclear MIIM′III species are prepared. The complexes have been characterised by X‐ray crystallography and show unusually short O⋅⋅⋅O distances for the hydrogen bonds. Magnetic measurements show the hydrogen‐bond bridges can lead to ferromagnetic or antiferromagnetic coupling. The electrochemistry of the dinuclear species is significantly different from the mononuclear systems: the latter show irreversible waves in cyclic voltammograms as a result of the need to couple proton and electron transfer. The dinuclear species, in contrast, show reversible waves, which are attributed to rapid intramolecular proton transfer facilitated by the hydrogen‐bonded structure.