bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease
Authors: Greenblatt Matthew B , Tsai Joy N , Wein Marc N 
Published: December 2016

AbstractBACKGROUNDDisorders of bone metabolism, most notably osteoporosis, are highly prevalent and predispose to fractures, causing high patient morbidity and mortality. Diagnosis and monitoring of bone metabolic defects can present a major challenge as these disorders are largely asymptomatic and radiographic measures of bone mass respond slowly to changes in bone physiology.CONTENTBone turnover markers (BTMs) are a series of protein or protein derivative biomarkers released during bone remodeling by osteoblasts or osteoclasts. BTMs can offer prognostic information on fracture risk that supplements radiographic measures of bone mass, but testing using BTMs has to take into account the large number of preanalytic factors and comorbid clinical conditions influencing BTM levels. BTMs respond rapidly to changes in bone physiology, therefore, they have utility in determining patient response to and compliance with therapies for osteoporosis.SUMMARYBTMs are a useful adjunct for the diagnosis and therapeutic monitoring of bone metabolic disorders, but their use has to be tempered by the known limitations in their clinical utility and preanalytic variables complicating interpretation.
Freges Kriterien der Sinngleichheit
Authors: Sander Thorsten 
Published: December 2016

Abstract:
Frege’s mature writings apparently contain two different criteria of sense identity. While in „Über Sinn und Bedeutung“ (1892) and in „Kurze Übersicht meiner logischen Lehren“ (1906?) Frege seems to advocate a psychological criterion, his letter to Husserl of December 12, 1906 offers a thoroughly logical criterion of sense identity. It is argued that the latter proposal is not a „momentary aberration“, but rather Frege’s official criterion; his psychological criteria only serve as a way of illustrating questions of sense identity by appealing to the thoughts of ideal thinkers.
Characterisation of lignin and lignin-carbohydrate complexes (LCCs) in prehydrolysed wood chips
Authors: Monot Claire , Chirat Christine , Evangelista Brieuc , Brochier-Salon Marie-Christine 
Published: December 2016

Abstract
Isolation and analysis of lignin and lignin-carbohydrate complexes (LCCs) were performed to understand the better delignification ability of prehydrolysed wood chips. Lignin analysis showed that prehydrolysis led to a slight depolymerisation and an increase in free phenolic group content. The yield measurement and composition analysis of LCCs of mixed softwoods (SWs) and mixed hardwoods (HWs) revealed essential differences. In the case of SW, the amounts of lignin and xylan involved in LCCs were significantly lowered, whereas in the case of HW, less cellulose, glucomannans, and xylans were detectable in the residual LCCs. The molecular mass distributions of glucomannan-lignin and xylan-lignin fractions were not changed significantly.
A Configurable Footswitch Unit for the Open Networked Neurosurgical OR – Development, Evaluation and Future Perspectives
Authors: Dell’Anna Jasmin , Janß Armin , Clusmann Hans , Radermacher Klaus 
Published: December 2016

Abstract
Footswitches are used in the neurosurgical operating room for human-device-communication every day. However, problems, such as shifting or confusion of footswitches, often occur due to the parallel usage of up to 5 device-specific footswitches, resulting in a significant burden for the surgeon. There are no footswitches available which offer an optional central activation of different devices from various manufacturers and a reconfiguration during usage. Therefore, a new concept of a configurable central footswitch unit has been developed for optional activation of different devices in an open networked neurosurgical OR setting. In a user-centered evaluation 9 surgeons used both, the configurable central footswitch unit and 4 device-specific footswitches, for a cross-over experiment in an experimental OR setting. It shows that all surgeons were able to handle the configurable footswitch autonomously and that efficiency in surgeon-device-communication can be increased.
Joint Decision Making and Cooperative Driver-Vehicle Interaction during Critical Driving Situations
Authors: Altendorf Eugen , Weßel Gina , Baltzer Marcel , Canpolat Yigiterkut , Flemisch Frank 
Published: December 2016

Abstract
In automated driving, the human driver and an automation form a joint human-machine system. In this system, each partner has her own individual cognitive as well as perceptual processes, which enable them to perform the complex task of driving. On different layers of the driving task, both, drivers and automation systems, assess the situation and derive action decisions. Although the processes can be divided between human and machine, and are sometimes very elaborate, the outcome should be a joint one because it affects the entire driver-vehicle system. In this paper, the individual processes for decision-making are defined and a framework for joint decision-making is proposed. Joint decision-making relies on common goals and norms of the two subsystems, human and automation, and evolves with experience.
Big Data in a Crisis? Creating Social Media Datasets for Crisis Management Research
Authors: Reuter Christian , Ludwig Thomas , Kotthaus Christoph , Kaufhold Marc-André , von Radziewski Elmar , Pipek Volkmar 
Published: December 2016

Abstract
A growing body of research in the area of information systems for crisis management is based on data from social media. After almost every larger disaster studies emerge with the focus on the specific use of social media. Much of this research is based on Twitter data, due to the ease of access of this (mainly public) data, compared to (more closed) data, such as Facebook or Google+. Based on the experience gained from a research project on social media in emergencies and our task to collect social media data sets for other partners, we present the design and evaluation of a graphical user interface that supports those stakeholders (such as emergency services or researchers) that are interested in creating social media datasets for further crisis management research. We do not specifically focus on the analysis of social media data. Rather we aim to support the gathering process and how actors without sophisticated technical skills can be supported to get what they want and especially need: relevant social media data. Within this article, we present a practice-oriented approach and implications for designing tools that support the collection of social media data as well as future work.
Long-term response to growth hormone therapy in a patient with short stature caused by a novel heterozygous mutation in NPR2
Authors: Vasques Gabriela A. , Hisado-Oliva Alfonso , Funari Mariana F.A. , Lerario Antonio M. , Quedas Elisangela P.S. , Solberg Paulo , Heath Karen E. , Jorge Alexander A.L. 
Published: December 2016

AbstractBackground:Heterozygous loss-of-function mutations in the natriuretic peptide receptor B gene (Case presentation:The proband was a healthy boy who presented at the age of 5.1 years with familial short stature (height SDS of −3.1). He had a prominent forehead, a depressed nasal bridge, centripetal fat distribution and a high-pitched voice resembling that of children with GH deficiency. His hormonal evaluation showed low insulin-like growth factor-1 (IGF-1) but a normal GH peak at a stimulation test. During the first year of rhGH treatment, his growth velocity increased from 3.4 to 10.4 cm/year (height SDS change of +1.1). At the last visit, he was 8.8 years old and still on treatment, his growth velocity was 6.4 cm/year and height SDS was −1.8.Results:We identified through exome sequencing a novel heterozygous loss-of-functionConclusions:This case reveals a novel heterozygous loss-of-function
Nocturnal levels of chemerin and progranulin in adolescents: influence of sex, body mass index, glucose metabolism and sleep
Authors: Daxer Johann , Herttrich Theresa , Zhao Ying Y. , Vogel Mandy , Hiemisch Andreas , Scheuermann Kathrin , Körner Antje , Kratzsch Jürgen , Kiess Wieland , Quante Mirja 
Published: December 2016

AbstractBackground:Adipokines have been implicated in obesity, insulin resistance and sleep regulation. However, the role of chemerin and progranulin, two recently described adipokines, in the context of sleep remains unclear. The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism.Methods:The study sample included 34 overweight/obese and 32 normal-weight adolescents from secondary schools and the Leipzig Research Center for Civilization Diseases (LIFE) Child study cohort. We obtained longitudinal serum adipokine levels during in-laboratory polysomnography followed by an oral glucose tolerance test.Results:Overweight/obese adolescents had significantly higher mean nocturnal serum chemerin area under the curve (AUC) levels (348.2±133.3 vs. 241.7±67.7 vs. ng/mL×h, p<0.001) compared to normal-weight controls. In detail, higher chemerin AUC levels in obese/overweight subjects were exclusively due to increased levels in females. No overall difference for serum progranulin AUC was found between the groups. However, when assessing sex-specific levels, serum progranulin AUC levels were ~30% higher in overweight/obese males compared to overweight/obese females. Of note, nocturnal serum chemerin and progranulin AUC did not exhibit a correlation with markers of glucose metabolism or sleep stages.Conclusions:Collectively, we report a sexual dimorphism in nocturnal progranulin and chemerin levels, which may help explain underlying differences in energy balance and body composition between males and females in the context of obesity.
Recombinant vascular endothelial growth factor 121 injection for the prevention of fetal growth restriction in a preeclampsia mouse model
Authors: Sulistyowati Sri , Bachnas Muhammad Adrianes , Anggraini Nuri Dyah , Yuliantara Eric Edwin , Prabowo Wisnu , Anggraini Nutria Widya Purna , Pramono Mochammad Besari Adi , Adityawarman  , Dachlan Erry Gumilar , Andonotopo Wiku 
Published: December 2016

AbstractAim:To discover the potential role of recombinant VEGFSubjects and methods:This is an experimental study of 30 pregnant mice that were randomly divided into three groups: normal, PE, and PE with rVEGFResults:On average, fetal birth weight was 0.7150 g in the normal group, 0.4936 g in the PE group, and 0.6768 g in the PE with rVEGFConclusions:Injection of rVEGF
Red blood cell morphology in patients with β-thalassemia minor
Authors: Körber Carolin , Wölfler Albert , Neubauer Manfred , Robier Christoph 
Published: December 2016

Abstract

Background:
A systematic analysis of the occurrence of red blood cell (RBC) abnormalities in β-thalassemia minor has not been performed to date. This study aimed to identify and quantify the frequency of RBC abnormalities in patients with β-thalassemia minor.

Methods:
We examined blood smears of 33 patients with β-thalassemia minor by light microscopy for the occurrence of 15 defined RBC abnormalities. In the case of positivity, the abnormal cells/20 high power fields (HPF) at 1000-fold magnification were counted.

Results:
Anisocytosis, poikilocytosis and target cells (median 42/20 HPF) were observed in all, and ovalocytes in 32 (96.9%, median 10/20 HPF) subjects. Dacryocytes (81.8%), stomatocytes (81.8%, median 10/20 HPF), elliptocytes (75.8%), cells with basophilic stippling (72.7%) and irregularly contracted cells (63.6%) were frequently, and schistocytes (15.2%), bite cells (6%) and pincer cells (3%) were occasionally found.

Conclusions:
Morphological abnormalities of erythrocytes are common in peripheral blood (PB) smears of patients with β-thalassemia minor. In this study, anisocytosis, poikilocytosis and target cells were apparent in all, and ovalocytes, elliptocytes, cells with basophilic stippling, dacryocytes, stomatocytes and irregularly contracted cells were observed in the majority of the analyzed slides. Our observations may be useful to improve the differential diagnosis of anemia in clinical laboratory routine.
Effect of conductive copolymers on scale formation of gypsum
Authors: Dogan Özlem , Senol Erdemir Cagri , Akyol Emel , Kirboga Semra , Öner Mualla 
Published: December 2016

Abstract
The crystallization of scale forming minerals is an important problem in a number of processes. Calcium sulfate dihydrate (CaSO4·2H2O, gypsum) is the most unwelcome deposit in the production of oil and gas, in water cooling systems and in hydrometallurgical processes. Additives have been used in these processes to prevent the formation and deposition of scaling salts. In this study, the effects of additives on the spontaneuos precipitation of CaSO4·2H2O were investigated in aqueous solutions at 30°C. Conductive copolymers with different vinylphosphonic acid (VPA) contents were used as additives. The degree of inhibition of cystallization was measured as an increase in induction time and the reduction in crystallization rate. The crystallization reactions were interpreted in terms of the Langmuir adsorption isotherm. The cystals were characterized by scanning electron microscope (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The VPA content of the copolymer and the supersaturation of the solution were found to be effective parameters on CaSO4·2H2O crystallization.
Die spirituelle Dimension beim Erleben schwerer psychiatrischer Krankheiten Existenzphilosophische Überlegungen und klinische Fallbeispiele
Authors: Stotz-Ingenlath Gabriele 
Published: December 2016

Zusammenfassung
Im psychiatrischen Alltag wird die spirituelle Dimension einer Erkrankung meist nicht explizit berücksichtigt. Dabei spielt sie bei den großen psychiatrischen Diagnosen oft eine wesentliche Rolle und zwar sowohl auf der Seite des Patienten als pathogenetischer und/oder heilsamer Faktor als auch auf der Seite des Behandlers, der mit der Grenzsituation einer schweren psychiatrischen Erkrankung existenziell konfrontiert wird. Dies soll an Fallbeispielen zu Demenz, Sucht, Schizophrenie, Depression, Manie und Angsterkrankung gezeigt werden.
The use of six sigma methodology to evaluate the analytical performances of clinical chemistry analyzers
Authors: Gülbahar Özlem , Kocabıyık Murat , Çıracı Mehmed Zahid , Demirtaş Canan , Uçar Fatma , Bayraktar Nilüfer , Akbıyık Filiz , Taşlıpınar Mine 
Published: December 2016

Abstract

Introduction
In our study, we aimed to evaluate the analytical process performances of the biochemistry tests in the analysis systems that were widely used in the clinical laboratories by using the six-sigma methodology.

Methods
The analytical performances of four different analytical platforms (Beckman Coulter-Olympus AU2700, Abbott-Architect C8000, Roche-Cobas 8000, and Siemens-ADVIA 2400) running 18 biochemical tests (urea, creatinine, uric acid, total bilirubin, AST, ALT, ALP, LDH, HDL-C, Ca2+, cholesterol, TG, glucose, total protein, albumin, Na+, K+, and Cl−) were evaluated. Biases and CV were obtained from internal quality control programs. The performance of each instrument was assessed using the σ scale; the benchmark performance was <3 σ (improvement needed); “world-class” quality was six sigma.

Results
The parameters that have σ≥6 which means in world class are HDL-C and ALP in all four systems, while only Na+ has σ<3 which point out the need to develop. Similarities and differences were found between systems for analytical process sigma values of all tests except these.

Discussion and conclusion
To improvement and monitoring of the analytical process performance as a part of total quality of a clinical laboratory to provide continuous improving, sigma levels can be used as it is a reliable method.
Residual Symmetries and Interaction Solutions for the Classical Korteweg-de Vries Equation
Authors: Fei Jin-Xi , Cao Wei-Ping , Ma Zheng-Yi 
Published: December 2016

Abstract
The non-local residual symmetry for the classical Korteweg-de Vries equation is derived by the truncated Painlevé analysis. This symmetry is first localised to the Lie point symmetry by introducing the auxiliary dependent variables. By using Lie’s first theorem, we then obtain the finite transformation for the localised residual symmetry. Based on the consistent tanh expansion method, some exact interaction solutions among different non-linear excitations are explicitly presented finally. Some special interaction solutions are investigated both in analytical and graphical ways at the same time.
Low-Intensity Sprint Training With Blood Flow Restriction Improves 100-m Dash
Authors: Behringer Michael , Behlau Daniel , Montag Johannes C.K. , McCourt Molly L. , Mester Joachim 
Published: December 2016

Abstract
Behringer, M, Behlau, D, Montag, JCK, McCourt, ML, and Mester, J. Low-intensity sprint training with blood flow restriction improves 100-m dash. J Strength Cond Res 31(9): 2462–2472, 2017—We investigated the effects of practical blood flow restriction (pBFR) of leg muscles during sprint training on the 100-m dash time in well-trained sport students. Participants performed 6 × 100-m sprints at 60–70% of their maximal 100-m sprinting speed twice a week for 6 weeks, either with (intervention group [IG]; n = 12) or without pBFR (control group [CG]; n = 12). The 100-m dash time significantly decreased more in the IG (−0.38 ± 0.24 seconds) than in the CG (−0.16 ± 0.17 seconds). The muscle thickness of the rectus femoris increased only in the IG, whereas no group-by-time interactions were found for the muscle thickness of the biceps femoris and the biceps brachii. The maximal isometric force, measured using a leg press, did not change in either group. However, the rate of force development improved in the IG. Growth hormone, testosterone, insulin-like growth factor 1, and cortisol concentrations did not significantly differ between both groups at any measurement time point (pre, 1 minute, 20 minutes, 120 minutes, and 24 hours after the 6 all-out sprints of the first training session). The muscle damage marker h-FABP increased significantly more in the CG than in the IG. The pBFR improved the 100-m dash time significantly more than low-intensity sprint interval training alone. Other noted benefits of training with pBFR were a decreased level of muscle damage, a greater increase of the rectus femoris muscle thickness, and a higher rate of force development. However, the tested hormones were unable to explain the additional beneficial effects.
Effects of a Modified German Volume Training Program on Muscular Hypertrophy and Strength
Authors: Amirthalingam Theban , Mavros Yorgi , Wilson Guy C. , Clarke Jillian L. , Mitchell Lachlan , Hackett Daniel A. 
Published: December 2016

Abstract
Amirthalingam, T, Mavros, Y, Wilson, GC, Clarke, JL, Mitchell, L, and Hackett, DA. Effects of a modified German volume training program on muscular hypertrophy and strength. J Strength Cond Res 31(11): 3109–3119, 2017—German Volume Training (GVT), or the 10 sets method, has been used for decades by weightlifters to increase muscle mass. To date, no study has directly examined the training adaptations after GVT. The purpose of this study was to investigate the effect of a modified GVT intervention on muscular hypertrophy and strength. Nineteen healthy men were randomly assign to 6 weeks of 10 or 5 sets of 10 repetitions for specific compound resistance exercises included in a split routine performed 3 times per week. Total and regional lean body mass, muscle thickness, and muscle strength were measured before and after the training program. Across groups, there were significant increases in lean body mass measures, however, greater increases in trunk (p = 0.043; effect size [ES] = −0.21) and arm (p = 0.083; ES = −0.25) lean body mass favored the 5-SET group. No significant increases were found for leg lean body mass or measures of muscle thickness across groups. Significant increases were found across groups for muscular strength, with greater increases in the 5-SET group for bench press (p = 0.014; ES = −0.43) and lat pull-down (p = 0.003; ES = −0.54). It seems that the modified GVT program is no more effective than performing 5 sets per exercise for increasing muscle hypertrophy and strength. To maximize hypertrophic training effects, it is recommended that 4–6 sets per exercise be performed, as it seems gains will plateau beyond this set range and may even regress due to overtraining.
Excess Blood Flow Response to Acute Resistance Exercise in Individuals Who are Obese or Nonobese
Authors: Lipford Grayson F. , Evans Ronald K. , Acevedo Edmund O. , Wolfe Luke G. , Franco R. Lee 
Published: December 2016

Abstract
Lipford, GF, Evans, RK, Acevedo, EO, Wolfe, LG, and Franco, RL. Excess blood flow response to acute resistance exercise in individuals who are obese or nonobese. J Strength Cond Res 31(11): 3120–3127, 2017—Resistance exercise (RE) is a commonly recommended treatment option for obese individuals. However, little is known regarding alterations in vasodilatory responses to RE, which could impair exercise tolerance. No studies to date have compared microvascular vasodilatory capacity, assessed by excess blood flow (EBF), responses in individuals who are obese or nonobese following acute RE. The purpose of the study was to evaluate EBF before and up to 24-hour after a single RE bout in obese (n = 18, 38.1 ± 7.64% body fat) and nonobese (n = 10, 23.6 ± 4.03% body fat) individuals who volunteered to participate. Each subject completed a leg flexion and knee extension one repetition maximum (1RM) test, and subsequently completed 4 sets of 8 repetitions at 85% of 1RM. Excess blood flow, adiponectin, and tumor necrosis factor α (TNF-α) were evaluated at baseline (PRE-RE), immediately after (POST-RE), and 1 (POST-1) and 24 (POST-24) hours after exercise. A repeated-measures analysis of variance revealed a significant interaction for EBF between the 2 groups (p = 0.029). The estimated marginal means plot suggested that obese individuals had a significant increase in POST-RE EBF in comparison with PRE-RE EBF (428.54 ± 261.59 vs. 547.00 ± 311.15 ml/100 ml/min·s; p = 0.046). In addition, EBF significantly decreased at POST-24 in comparison with POST-RE in the obese individuals (547.00 ± 311.15 vs. 389.33 ± 252.32 ml/100 ml/min·s; p = 0.011). Changes in EBF were not related to adiponectin or TNF-α. An acute bout of RE resulted in an opposite EBF response between nonobese and obese individuals immediately after RE. Furthermore, only the obese individuals displayed a significant increase in EBF immediately after RE, which was significantly reduced 24 hours after the RE bout. Microvascular vasodilatory capacity may alter the adaptive exercise response associated with RE, requiring alterations to frequency, intensity, and/or duration that are specific to populations of various body composition profiles.