bluuebunny/crossref_metadata_2025_split huggingface dataset:
“If you had the chance to like, not show people like a bad part of you… you would do it”: Perceptions of Offline Versus Online Social Media Identity Among Emerging Adults From Socio-Demographic Minority Groups in the U.S.
Authors: Dubar Royette T. , Greene Danielle , Watkins Nicole K. 
Published: October 2024

During the COVID-19 pandemic, social media became an especially salient tool for interpersonal connections due to public policy limitations on in-person contact; but little is known about how emerging adults from various socio-demographic minority groups in the U.S. engaged with social media as a tool for identity construction during the pandemic. This qualitative interview study examined the role of social media engagement in perceptions of online versus offline identity during the pandemic. Participants were 24 emerging adults ( M = 18.9 years old, SD = 0.44) from various socio-demographic minority groups. Results of thematic analysis indicated 5 themes: (i) ‘ Highlight reel vs. real life’, (ii) ‘Navigating authenticity’, (iii) ‘Proceed with caution: Fear of judgment’ (iv) ‘Social media as an identity tool’, and (v) ‘The evolved social media identity’. Social media plays a critical role in emerging adults’ identity development by providing both opportunities and challenges for self-expression, emotion regulation, and self-reflection.
Concussion in Female Athletes of Contact Sports: A Scoping Review
Authors: Fahr Jana , Kraff Oliver , Deuschl Cornelius , Dodel Richard 
Published: October 2024

Background: Recent studies have described higher incidences of concussion, with more severe symptoms and worse outcomes in female athletes compared with male athletes. Purpose: To compile current knowledge about sex-specific differences in incidence, biomechanics, biomarkers, imaging, and outcomes of concussion in athletes participating in contact sports to better understand which fields should be explored in more detail. Study Design: Scoping review; Level of evidence, 3. Methods: The PubMed database was searched for articles published between January 2000 and November 2020 using the Medical Subject Headings terms “craniocerebral trauma” and “brain concussion” combined with the contact sports “football,”“soccer,”“hockey,” and “boxing.” Eligibility criteria were based on the recommendations of the Scottish Intercollegiate Guidelines Network. It focused on sex-specific differences within 5 major topics: (1) epidemiology, (2) biomechanics, (3) biomarkers, (4) imaging, and (5) specific concussion outcome variables, including neurocognitive performance, injury severity, and behavioral and psychological symptoms. Results: A total of 22 studies were included. Eight studies investigated the incidence of concussion, with 4 of the 8 finding a significantly higher incidence rate for female versus male athletes. Six studies that focused on biomechanics found that female athletes received fewer impacts with lower magnitudes. One study addressed biomarkers, showing that S100 calcium-binding protein B and neuron-specific enolase were increased after a game in female athletes, and the level of increase was similar to the changes found in male athletes. Based on the 3 imaging studies, affected brain tissue was greatest in areas associated with tau pathology in chronic traumatic encephalopathy. One study showed a lower hypointensity burden index after a season of ice hockey for female athletes, while another study showed more regions with white matter alterations. Seven studies examined concussion outcomes, with 4 studies showing more severe neuropsychological deficits; in addition, female athletes reported more and worse symptoms than male athletes. Conclusion: The results of this review indicated that female athletes had a higher risk of sustaining a concussion, although they received fewer impacts with lower magnitudes than male athletes. Biomarkers were able to be used equally for both sexes. Female athletes also had a higher neuropsychological deficit and increasingly worse symptoms after a concussion.
Use of a Low Profile Ultra-High Molecular Weight Polyethylene Diaphyseal Humeral Cement Restrictor in Shoulder Arthroplasty
Authors: Bond Elizabeth C , Finley Suzanne , Pennington Elizabeth , Reinke Emily K , McGarvey Lewis , Garrigues Grant E , Lassiter Tally E , Anakwenze Oke A 
Published: October 2024

Background When implanting a cemented humeral stem, a reliable method to prevent inappropriate extension and enable pressurization of cement in the intramedullary canal is required. The aim was to assess the outcomes of a dedicated humeral diaphyseal cement restrictor. Methods In total 218 shoulders (207 patients) were included in the study, all of whom underwent a cemented total shoulder arthroplasty and a retrospective review was performed. The primary outcomes of interest were device stability in the medullary canal, successful occlusion of the canal, cement extrusion and quality of cement mantle. Results The majority of the cohort was female (63.3%) males and the average patient age was 71.7 years (SD 8.45). In 81.7% the device was deemed to be stable in the medullary canal. The device was significantly more stable in primary (84.2%) compared to revision cases (64.3%, p = 0.02). In 69.7% Barrack grade A mantle quality was achieved, this was higher in primary cases (74.2%) compared to revision cases (39.3%) (p = 0.00006). Discussion We noted excellent cementation outcomes using a cement restrictor specifically designed for the diaphyseal humerus anatomy. However, this humeral specific restrictor was noted to be more stable in primary as compared to revision cases.
View of intensive care units nurses toward factors related to missed nursing
Authors: Eghbali Tayebeh , Ahmadi Nejad Mehdi , Dehghan Mahlegha , Maazallahi Mahboobeh , Rahiminezhad Elham , Azizzadeh Forouzi Mansooreh 
Published: October 2024

Background Missed nursing care is defined as aspects of care needed by patients that are completely or partially omitted or significantly delayed. Various factors may lead to missed care. Investigating factors related to missed care and their occurrence can prevent or minimize risks to patient safety. The present study was conducted to investigate factors related to missed nursing care in intensive care units. Method This was a descriptive cross-sectional study. The study sample comprised 255 nurses working in the intensive care units of Kerman University of Medical Sciences. Questionnaires regarding demographic characteristics and factors related to missed nursing care were used to collect data. Descriptive statistics (mean and standard deviation) and inferential statistics (independent t-tests and one-way analysis of variance) were employed for data analysis. Results The mean score of factors related to missed nursing care was 77.63 ± 63.13 (ranging from 20 to 80), which exceeded the average score of the questionnaire (30). The highest mean scores for factors related to missed care were observed for “lack of nursing staff,” “malfunction of equipment when needed,” and “emergency conditions of patients (e.g., deterioration of the patient's condition)” respectively. The lowest mean score was associated with “tension or poor communication with other aid and support centers” and “tension or weak communication within the nursing team.” Conclusions Based on the findings, providing mental and physical support, ensuring adequate facilities, and hiring skilled and experienced caregivers can help reduce instances of missed nursing care.
Unlocking compassion: expanding access to palliative care in Saudi Arabia
Authors: Almobarak Fhaied 
Published: October 2024

Background: Palliative care is an essential element of the healthcare system. It has profound benefits for patients with life-limiting illnesses. The Saudi Arabian healthcare system lags in integrating this vital component effectively. Hence, estimating the palliative care needs of the Saudi Arabian population is crucial to understanding the country’s demand for palliative care. Aim: To assess the past trends in adult palliative care needs in Saudi Arabia. Methods: The current research used population-based secondary data analysis by employing two palliative care needs estimation methods: the direct or fixed estimation method by Gómez-Batiste and the maximum or maximal method by Murtagh and Rosenwax. The estimated palliative care needs were stratified by gender. Results: An upward trend in the palliative care needs of the Saudi Arabian population is evident through the estimation techniques. The proportion of palliative care needs relative to deaths climaxed at 95% in the observed years. By 2022, the number of people requiring palliative care skyrocketed to 79,725 (fixed method) and 101,623 (maximal method). Conclusion: The need for palliative care in Saudi Arabia substantially rose in the observed years. It is inevitable to bridge the gap between palliative care needs and supply with advanced integration of palliative care services in the national healthcare system.
Mapping the future: A scoping analysis of paediatric content in Australian paramedic curriculum
Authors: Peasey Rachel , Ross Linda , McCartan Julia , Bowles Kelly-Ann 
Published: October 2024

Introduction The rise of formal degree programs has significantly expanded professional and independent paramedicine systems globally. Paramedicine now includes a wide range of responsibilities, from managing life-threatening conditions to addressing diverse patient needs. However, current education frameworks often lack specificity, being largely adapted from other clinical disciplines. This study aims to provide a comprehensive description of the current state of undergraduate paramedic education concerning paediatric content in Australia. Methods A content analysis was conducted on publicly available curriculums from accredited Australian universities offering Bachelor of Paramedicine programs. Initial data analysis involved searching for paediatric terminology in learning outcomes and/or synopses. Subsequent analysis of curricula from institutions that completed member checking comprised two components: a descriptive arm to quantitatively assess paediatric education and an inductive arm to qualitatively explore categories of paediatric curriculum. Results Curriculum of 15/16 programs were searched, revealing a median of three units which included paediatric terminology in learning outcomes or unit synopses. Four institutions across five Australian states completed member checking, revealing a national median paediatric content inclusion of 0%. Only 32% of units included any paediatric content, with a median inclusion of 10%. Examination of the hidden aspects of curriculum highlighted discrepancies between learning outcomes and paediatric content percentages. No overarching degree learning outcomes mentioned paediatrics. Unit learning outcomes that had paediatric mention were categorised into three groups: content, conceptual understanding and skills development. Additionally, distribution analysis revealed a notable emphasis on non-technical skills, potentially overshadowing core knowledge essential for paediatric care. Discussion The findings underscore the need for curriculum reform, to enhance paramedic student preparedness to manage paediatrics. Scaffolding paediatric content into the curriculum could foster a comprehensive understanding of patient care and mitigate disparities in paediatric management. Collaboration with stakeholders and innovative teaching methodologies hold promise for advancing paediatric education in paramedicine.
Gene therapy in transfusion-dependent non-β0/β0 genotype β-thalassemia: first real-world experience of beti-cel
Authors: Mirza Adil , Ritsert Mona-Lisa , Tao Gloria , Thakar Himal , Lobitz Stephan , Heine Sabine , Koscher Leila , Dürken Matthias , Schmitt Anita , Schmitt Michael , Pavel Petra , Laier Sascha , Jakoby Donate , Greil Johann , Kunz Joachim , Kulozik Andreas 
Published: October 2024

Abstract
Gene addition and editing strategies for transfusion-dependent β-thalassemia have gained momentum as potentially curative treatment options, with studies showcasing their efficacy and safety. We report, to our knowledge, the first real-world application of betibeglogene autotemcel (beti-cel; Zynteglo) during its period of active license in Europe from January 2020 to March 2022 for patients aged ≥12 years without a β0/β0 genotype and without a HLA-matched sibling donor, before beti-cel marketing authorization was withdrawn by its holder because of nonsafety reasons. Among 15 screened patients, 4 opted out for fertility and safety concerns, 2 were excluded because of marked hepatic siderosis, and 1 had apheresis collection failure. Eight patients received beti-cel after busulfan myeloablative conditioning, all achieving transfusion independence within 8 to 59 days, with posttreatment hemoglobin levels ranging from 11.3 to 19.3 g/dL. No deaths occurred, but acute toxicity mirrored busulfan’s known effects. Posttreatment platelet management faced challenges because of HLA-antibodies in 3 patients. Monitoring up to month 24 revealed pituitary-gonadal endocrine dysfunction in all 3 female and in 2 of 5 male patients. Additionally, we observed unexpected posttreatment sequelae: 1 patient developed polycythemia that could not be explained by known genetic or acquired mechanisms, 1 patient developed posttreatment depression and anxiety prohibiting her from returning to work, and 1 patient developed fatigue severely compromising both quality of life and work capacity. This real-world experience corroborates beti-cel’s efficacy and safety and provides information on adverse events observed during real-world use of the therapy.
Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia
Authors: Joudinaud Romane , Boudry Augustin , Fenwarth Laurène , Geffroy Sandrine , Salson Mikaël , Dombret Hervé , Berthon Céline , Pigneux Arnaud , Lebon Delphine , Peterlin Pierre , Bouzy Simon , Flandrin-Gresta Pascale , Tavernier Emmanuelle , Carre Martin , Tondeur Sylvie , Haddaoui Lamya , Itzykson Raphael , Bertoli Sarah , Bidet Audrey , Delabesse Eric , Hunault Mathilde , Récher Christian , Preudhomme Claude , Duployez Nicolas , Dumas Pierre-Yves 
Published: October 2024

Abstract
Despite the use of midostaurin (MIDO) with intensive chemotherapy (ICT) as frontline treatment for Fms-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML), complete remission rates are close to 60% to 70%, and relapses occur in &gt;40% of cases. Here, we studied the molecular mechanisms underlying refractory/relapsed (R/R) disease in patients with FLT3-mutated AML. We conducted a retrospective and multicenter study involving 150 patients with R/R AML harboring FLT3–internal tandem duplication (ITD) (n = 130) and/or FLT3–tyrosine kinase domain mutation (n = 26) at diagnosis assessed by standard methods. Patients were treated with ICT + MIDO (n = 54) or ICT alone (n = 96) according to the diagnosis date and label of MIDO. The evolution of FLT3 clones and comutations was analyzed in paired diagnosis–R/R samples by targeted high-throughput sequencing. Using a dedicated algorithm for FLT3-ITD detection, 189 FLT3-ITD microclones (allelic ratio [AR] of &lt;0.05) and 225 macroclones (AR ≥ 0.05) were detected at both time points. At R/R disease, the rate of FLT3-ITD persistence was lower in patients treated with ICT + MIDO than in patients not receiving MIDO (68% vs 87.5%; P = .011). In patients receiving ICT + MIDO, detection of multiple FLT3-ITD clones was associated with a higher FLT3-ITD persistence rate at R/R disease (multiple clones: 88% vs single clones: 57%; P = .049). If only 24% of FLT3-ITD microclones detected at diagnosis were retained at relapse, 43% became macroclones. Together, these results identify parameters influencing the fitness of FLT3-ITD clones.
Integrated respiratory care: what forms may it take and what are the benefits to patients?
Authors: Patel I. 
Published: October 2024

Educational aimsTo outline the rationale behind and key components of integrated respiratory care.To give an overview of different models of delivery of integrated respiratory care.To explore the benefits to patients with chronic respiratory disease.SummaryProviding for the long-term needs of patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), sets new challenges for healthcare organisations in terms of structure and funding. Integrated respiratory care is a holistic patient-centred approach to long-term conditions encompassing: disease prevention and promotion of lung health; early diagnosis; monitoring and education; coordination of hospital and community care; and implementation of evidence-based guidelines. Models of integrated respiratory care may vary depending on local resources and needs. Key aspects include nurse-led care nearer to or in the patients' home, self-management support, flexible healthcare design that suits patient needs, effective information sharing, and access to specialist care. These interventions have the potential to improve self-care and understanding of disease, reduce the need for scheduled and unscheduled consultations and length of stay, and enhance patients' health-related quality of life.
Research progress of ankyrin repeat domain 1 protein: an updated review
Authors: Xu Xusan , Wang Xiaoxia , Li Yu , Chen Riling , Wen Houlang , Wang Yajun , Ma Guoda 
Published: October 2024

AbstractAnkyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that Ankrd1 plays a crucial role in a wide range of biological processes and diseases. This review consolidates current knowledge on Ankrd1’s functions in myocardium and skeletal muscle development, neurogenesis, cancer, bone formation, angiogenesis, wound healing, fibrosis, apoptosis, inflammation, and infection. The comprehensive profile of Ankrd1 in cardiovascular diseases, myopathy, and its potential as a candidate prognostic and diagnostic biomarker are also discussed. In the future, more studies of Ankrd1 are warranted to clarify its role in diseases and assess its potential as a therapeutic target.
Tinnitus is associated with increased extracellular matrix density in the auditory cortex of Mongolian gerbils
Authors: Tziridis Konstantin , Maul Antonia , Rasheed Jwan , Krauss Patrick , Schilling Achim , Schulze Holger 
Published: October 2024

AbstractMost scientists agree that subjective tinnitus is the pathological result of an interaction of damage to the peripheral auditory system and central neuroplastic adaptations. Here we investigate such tinnitus related adaptations in the primary auditory cortex (AC) 7 and 13 days after noise trauma induction of tinnitus by quantifying the density of the extracellular matrix (ECM) in the AC of Mongolian gerbils (Meriones unguiculatus). The ECM density has been shown to be relevant for neuroplastic processes and synaptic stability within the cortex. We utilized a mild monaural acoustic noise trauma in overall 22 gerbils to induce tinnitus and a sham exposure in 16 control (C) animals. Tinnitus was assessed by a behavioral response paradigm. Animals were separated for a presence (T) or absence (NT) of a tinnitus percept by a behavioral task. The ECM density 7 and 13 days after trauma was quantified using immunofluorescence luminance of Wisteria floribunda lectin-fluoresceine-5-isothiocyanate (WFA-FITC) on histological slices of the primary AC, relative to the non-auditory brainstem as a reference area. At both timepoints, we found that the WFA-FITC luminance of the AC of NT animals was not significantly different from that of C animals. However, we found a significant increase of luminance in T animals’ ACs compared to NT or C animals’ cortices. This effect was found exclusively on the AC side contralateral to the trauma ear. These results point to a hemisphere specific process of stabilization of synaptic connections in primary AC, which may be involved in the chronic manifestation of tinnitus.
Exploring bias risks in artificial intelligence and targeted medicines manufacturing
Authors: Nwebonyi Ngozi , McKay Francis 
Published: October 2024

Abstract
Background
Though artificial intelligence holds great value for healthcare, it may also amplify health inequalities through risks of bias. In this paper, we explore bias risks in targeted medicines manufacturing. Targeted medicines manufacturing refers to the act of making medicines targeted to individual patients or to subpopulations of patients within a general group, which can be achieved, for example, by means of cell and gene therapies. These manufacturing processes are increasingly reliant on digitalised systems which can be controlled by artificial intelligence algorithms. Whether and how bias might turn up in the process, however, is uncertain due to the novelty of the development.

Methods
Examining stakeholder views across bioethics, precision medicine, and artificial intelligence, we document a range of opinions from eleven semi-structured interviews about the possibility of bias in AI-driven targeted therapies manufacturing.

Result
Findings show that bias can emerge in upstream (research and development) and downstream (medicine production) processes when manufacturing targeted medicines. However, interviewees emphasized that downstream processes, particularly those not relying on patient or population data, may have lower bias risks. The study also identified a spectrum of bias meanings ranging from negative and ambivalent to positive and productive. Notably, some participants highlighted the potential for certain biases to have productive moral value in correcting health inequalities. This idea of “corrective bias” problematizes the conventional understanding of bias as primarily a negative concept defined by systematic error or unfair outcomes and suggests potential value in capitalizing on biases to help address health inequalities. Our analysis also indicates, however, that the concept of “corrective bias” requires further critical reflection before they can be used to this end.
Inconsistent values and algorithmic fairness: a review of organ allocation priority systems in the United States
Authors: Dale Reid , Cheng Maggie , Pines Katharine Casselman , Currie Maria Elizabeth 
Published: October 2024

Abstract
Background
The Organ Procurement and Transplant Network (OPTN) Final Rule guides national organ transplantation policies, mandating equitable organ allocation and organ-specific priority stratification systems. Current allocation scores rely on mortality predictions.

Methods
We examined the alignment between the ethical priorities across organ prioritization systems and the statistical design of the risk models in question. We searched PubMed for literature on organ allocation history, policy, and ethics in the United States.

Results
We identified 127 relevant articles, covering kidney (19), liver (60), lung (24), and heart transplants (23), and transplant accessibility (1). Current risk scores emphasize model performance and overlook ethical concerns in variable selection. The inclusion of race, sex, and geographical limits as categorical variables lacks biological basis; therefore, blurring the line between evidence-based models and discrimination. Comprehensive ethical and equity evaluation of risk scores is lacking, with only limited discussion of the algorithmic fairness of the Model for End-Stage Liver Disease (MELD) and the Kidney Donor Risk Index (KDRI) in some literature. We uncovered the inconsistent ethical standards underlying organ allocation scores in the United States. Specifically, we highlighted the exception points in MELD, the inclusion of race in KDRI, the geographical limit in the Lung Allocation Score, and the inadequacy of risk stratification in the Heart Tier system, creating obstacles for medically underserved populations.

Conclusions
We encourage efforts to address statistical and ethical concerns in organ allocation models and urge standardization and transparency in policy development to ensure fairness, equitability, and evidence-based risk predictions.