bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistence With Conventional Triple Therapy Versus a Tumor Necrosis Factor Inhibitor and Methotrexate in US Veterans With Rheumatoid Arthritis
Authors: Sauer Brian C. , Teng Chia‐Chen , Tang Derek , Leng Jianwei , Curtis Jeffrey R. , Mikuls Ted R. , Harrison David J. , Cannon Grant W. 
Published: June 2016

ObjectiveTo compare persistence and adherence to triple therapy with the nonbiologic disease‐modifying antirheumatic drugs (DMARDs) methotrexate (MTX), hydroxychloroquine, and sulfasalazine, versus a tumor necrosis factor inhibitor (TNFi) plus MTX in patients with rheumatoid arthritis (RA).MethodsAdministrative and laboratory data were analyzed for US Veterans with RA initiating triple therapy or TNFi + MTX between January 2006 and December 2012. Treatment persistence 365 days postindex was calculated using 3 definitions. Definition 1 required no gap in therapy of ≥90 days for any drug in the original combination. Definition 2 required no added or switched DMARD, no decrease to nonbiologic DMARD monotherapy, and no termination of all DMARD therapies. Definition 3 was similar to definition 2 but allowed a switch to another drug within the same class. Adherence used a proportion of days covered of ≥80%. Propensity‐weighted analysis with matched weights was used to balance covariates.ResultsThe analysis included 4,364 RA patients (TNFi + MTX, n = 3,204; triple therapy, n = 1,160). In propensity‐weighted analysis, patients in the TNFi + MTX group were significantly more likely than patients in the triple therapy group to satisfy all persistence criteria in definition 1 (risk difference [RD] 13.1% [95% confidence interval (95% CI) 9.2–17.0]), definition 2 (RD 6.4% [95% CI 2.3–10.5]), and definition 3 (RD 9.5% [95% CI 5.5–13.6]). Patients in the TNFi + MTX group also exhibited higher adherence during the first year (RD 7.2% [95% CI 3.8–10.5]).ConclusionUS Veterans with RA were significantly more likely to be persistent and adherent to combination therapy with TNFi + MTX than triple therapy with nonbiologic DMARDs.
Supporting the Evaluation and Implementation of Musculoskeletal Models of Care: A Globally Informed Framework for Judging Readiness and Success
Authors: Briggs Andrew M. , Jordan Joanne E. , Jennings Matthew , Speerin Robyn , Bragge Peter , Chua Jason , Woolf Anthony D. , Slater Helen 
Published: June 2016

ObjectiveTo develop a globally informed framework to evaluate readiness for implementation and success after implementation of musculoskeletal models of care (MOCs).MethodsThree phases were undertaken: 1) a qualitative study with 27 Australian subject matter experts (SMEs) to develop a draft framework; 2) an eDelphi study with an international panel of 93 SMEs across 30 nations to evaluate face validity, and refine and establish consensus on the framework components; and 3) translation of the framework into a user‐focused resource and evaluation of its acceptability with the eDelphi panel.ResultsA comprehensive evaluation framework was developed for judging the readiness and success of musculoskeletal MOCs. The framework consists of 9 domains, with each domain containing a number of themes underpinned by detailed elements. In the first Delphi round, scores of “partly agree” or “completely agree” with the draft framework ranged 96.7%–100%. In the second round, “essential” scores ranged 58.6%–98.9%, resulting in 14 of 34 themes being classified as essential. SMEs strongly agreed or agreed that the final framework was useful (98.8%), usable (95.1%), credible (100%) and appealing (93.9%). Overall, 96.3% strongly supported or supported the final structure of the framework as it was presented, while 100%, 96.3%, and 100% strongly supported or supported the content within the readiness, initiating implementation, and success streams, respectively.ConclusionAn empirically derived framework to evaluate the readiness and success of musculoskeletal MOCs was strongly supported by an international panel of SMEs. The framework provides an important internationally applicable benchmark for the development, implementation, and evaluation of musculoskeletal MOCs.
Fulleretic Well‐Defined Scaffolds: Donor–Fullerene Alignment Through Metal Coordination and Its Effect on Photophysics
Authors: Williams Derek E. , Dolgopolova Ekaterina A. , Godfrey Danielle C. , Ermolaeva Evgeniya D. , Pellechia Perry J. , Greytak Andrew B. , Smith Mark D. , Avdoshenko Stanislav M. , Popov Alexey A. , Shustova Natalia B. 
Published: June 2016

AbstractHerein, we report the first example of a crystalline metal–donor–fullerene framework, in which control of the donor–fullerene mutual orientation was achieved through chemical bond formation, in particular, by metal coordination. The 13C cross‐polarization magic‐angle spinning NMR spectroscopy, X‐ray diffraction, and time‐resolved fluorescence spectroscopy were performed for comprehensive structural analysis and energy‐transfer (ET) studies of the fulleretic donor–acceptor scaffold. Furthermore, in combination with photoluminescence measurements, the theoretical calculations of the spectral overlap function, Förster radius, excitation energies, and band structure were employed to elucidate the photophysical and ET processes in the prepared fulleretic material. We envision that the well‐defined fulleretic donor–acceptor materials could contribute not only to the basic science of fullerene chemistry but would also be used towards effective development of organic photovoltaics and molecular electronics.
Using ionic liquid catalyst for conversion of waste polyethylene terephthalate and soybean oil to polyester polyol
Authors: Thi Le Bui Thuy , Anh Nguyen Dung , Van Ho Son , Thi Ngoc Uong Ha 
Published: June 2016

ABSTRACTAn imidazolium ionic liquid was synthesized, characterized and used as a catalyst for conversion of polyethylene terephthalate (PET) and soybean oil to polyester polyol (PE polyol). The degradation of PET waste was carried out using glycerol and low cost soybean oil that resulted in the formation of PE polyols. Formed PE polyols were characterized using Fourier transform infrared (FT‐IR) and mass spectra method, thermo gravimetric and differential thermal analysis and gel permeation chromatoghraphy. The first step in the overall process is proposed to be the transesterification of soybean oil with glycerol to form monoglyceride or/and diglyceride of soybean oil fatty acids. In the second step, the obtained glycerides can react with PET to form PE polyol. Both steps could be combined in one process and acidic catalyzed by an ionic liquid. Ionic liquid can be used as active catalyst and show a high reusability. The influence of some factors such as amount of glycerol used in transesterification of soybean oil with glycerol, PET degradation time, and temperature on PET conversion were investigated to find the suitable conditions for the process. Under suggested optimum parameters (mass ratio of soybean oil to glycerol of 2:1, a time of 8 h and a temperature of 180 °C for PET degradation), a PET conversion of 87.3% was reached. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43920.
Australia's Productivity: Some Insights from Productivity Analysis
Authors: Gordon Jenny 
Published: June 2016

AbstractSince the turn of the century, multifactor productivity has stagnated. Australia's income growth was supported until recent years by strong growth in the terms of trade and investment, but the terms of trade have been falling since 2011, and investment is slowing. To maintain at least the modest growth rate of the last decade, long term multifactor productivity growth needs to recover. The last decade or so has seen productivity challenges arising from natural resource depletion, as new mines were more costly to develop, and as technological replacements for environmental services, such as desalinisation plants, were increasingly introduced. Lags in the time required to bring major investments online also contributed to the poor performance. More broadly, shifts in tastes and technology have delivered quality improvements to consumers without increases in price commensurate to the additional inputs required, a trend that dampens nominal GDP growth and measured productivity.
Brief Report: Late‐Onset Cryopyrin‐Associated Periodic Syndrome Due to Myeloid‐Restricted Somatic NLRP3 Mosaicism
Authors: Mensa‐Vilaro Anna , Teresa Bosque María , Magri Giuliana , Honda Yoshitaka , Martínez‐Banaclocha Helios , Casorran‐Berges Marta , Sintes Jordi , González‐Roca Eva , Ruiz‐Ortiz Estibaliz , Heike Toshio , Martínez‐Garcia Juan J. , Baroja‐Mazo Alberto , Cerutti Andrea , Nishikomori Ryuta , Yagüe Jordi , Pelegrín Pablo , Delgado‐Beltran Concha , Aróstegui Juan I. 
Published: June 2016

ObjectiveGain‐of‐function NLRP3 mutations cause cryopyrin‐associated periodic syndrome (CAPS), with gene mosaicism playing a relevant role in the pathogenesis. This study was undertaken to characterize the genetic cause underlying late‐onset but otherwise typical CAPS.MethodsWe studied a 64‐year‐old patient who presented with recurrent episodes of urticaria‐like rash, fever, conjunctivitis, and oligoarthritis at age 56 years. DNA was extracted from both unfractionated blood and isolated leukocyte and CD34+ subpopulations. Genetic studies were performed using both the Sanger method of DNA sequencing and next‐generation sequencing (NGS) methods. In vitro and ex vivo analyses were performed to determine the consequences that the presence of the variant have in the normal structure or function of the protein of the detected variant.ResultsNGS analyses revealed the novel p.Gln636Glu NLRP3 variant in unfractionated blood, with an allele frequency (18.4%) compatible with gene mosaicism. Sanger sequence chromatograms revealed a small peak corresponding to the variant allele. Amplicon‐based deep sequencing revealed somatic NLRP3 mosaicism restricted to myeloid cells (31.8% in monocytes, 24.6% in neutrophils, and 11.2% in circulating CD34+ common myeloid progenitor cells) and its complete absence in lymphoid cells. Functional analyses confirmed the gain‐of‐function behavior of the gene variant and hyperactivity of the NLRP3 inflammasome in the patient. Treatment with anakinra resulted in good control of the disease.ConclusionWe identified the novel gain‐of‐function p.Gln636Glu NLRP3 mutation, which was detected as a somatic mutation restricted to myeloid cells, as the cause of late‐onset but otherwise typical CAPS. Our results expand the diversity of CAPS toward milder phenotypes than previously reported, including those starting during adulthood.
Effect of Comedication With Conventional Synthetic Disease‐Modifying Antirheumatic Drugs on Retention of Tumor Necrosis Factor Inhibitors in Patients With Spondyloarthritis: A Prospective Cohort Study
Authors: Sepriano A. , Ramiro S. , van der Heijde D. , Ávila‐Ribeiro P. , Fonseca R. , Borges J. , Teixeira L. , Carvalho P. D. , Cerqueira M. , Neves J. , Meirinhos T. , Barcelos A. , Sequeira G. , Salvador M. J. , Canas da Silva J. , Santos H. , Bernardes M. , Vieira‐Sousa E. , Canhão H. , Branco J. C. , Pimentel‐Santos F. , Landewé R. 
Published: June 2016

ObjectiveTo evaluate whether use of comedication with conventional synthetic disease‐modifying antirheumatic drugs (csDMARDs) influences the retention of tumor necrosis factor inhibitors (TNFi) in patients with spondyloarthritis (SpA).MethodsPatients with SpA from the Rheumatic Diseases Portuguese Register who started treatment with their first TNFi between 2001 and 2014 were included in this study. Cox regression analysis was used to estimate the effect of comedication with csDMARDs on TNFi retention in 2 types of models: a model in which baseline (time‐fixed) variables were included, and a second model incorporating time‐varying variables, including sociodemographic features, measures of disease activity, measures of physical function, and cotreatment with other drugs (nonsteroidal antiinflammatory drugs and oral steroids). To control for possible confounding by indication, the effect of csDMARD comedication on TNFi retention was also tested after adjustment for the treatment propensity score.ResultsIn total, 954 patients were included in the study, of whom 289 (30.3%) discontinued treatment with their first TNFi after a median follow‐up time of 2.5 years (range 0.08–13 years). Inefficacy was the most common reason for TNFi discontinuation (55.7% of patients). In the multivariable analyses, comedication with csDMARDs had no measurable effect on TNFi retention, neither in the baseline model (hazard ratio [HR] 0.83, 95% confidence interval [95% CI] 0.59–1.16) nor during follow‐up in the model adjusted for time‐varying covariates (HR 1.07, 95% CI 0.68–1.68). The effect of csDMARD comedication remained nonsignificant after propensity score adjustment.ConclusionComedication with csDMARDs does not prolong TNFi retention in patients with SpA in clinical practice, suggesting that there is no benefit conferred by the concomitant use of these drugs.
HLA–DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis
Authors: Ling Stephanie F. , Viatte Sebastien , Lunt Mark , Van Sijl Alper M. , Silva‐Fernandez Lucia , Symmons Deborah P. M. , Young Adam , Macgregor Alexander J. , Barton Anne 
Published: June 2016

ObjectiveRheumatoid arthritis (RA) susceptibility HLA–DRB1 haplotypes based on amino acid positions 11/13, 71, and 74 predict radiographic damage. The mechanism of action is unknown, but it may be mediated by inflammation. We undertook this study to systematically investigate the effect of these amino acids on nonradiographic measures of disease activity/outcomes.MethodsWe tested the association of RA susceptibility HLA–DRB1 amino acids with the C‐reactive protein (CRP) level, the tender joint count (TJC), the swollen joint count (SJC), the Disease Activity Score in 28 joints (DAS28), and the Health Assessment Questionnaire (HAQ) score in the Norfolk Arthritis Register (NOAR) and Early Rheumatoid Arthritis Study (ERAS) cohorts. Longitudinal modeling of disease activity/outcomes was performed using generalized linear latent and mixed models. Mediation analysis was performed using directed acyclic graphs to investigate the paths from genetic factors to outcome.ResultsA total of 2,158 patients were available for analysis in the NOAR cohort. Valine at position 11 showed the strongest association with the CRP level (P = 2.21 × 10−6), the SJC (P = 7.51 × 10−6), and the DAS28 (P = 0.002); it was marginally associated with the HAQ score (P = 0.044) but not with the TJC. The same amino acid and haplotype risk hierarchy observed for susceptibility and radiographic severity was observed for the CRP level and nonradiographic measures of disease activity/outcome, apart from the TJC. The results were replicated in the ERAS cohort. The effect of valine at position 11 on the SJC was mainly mediated by anti–citrullinated protein antibody status, the effect of which was mainly mediated by inflammation; however, the effect of valine at position 11 was also independent of the CRP level (P = 1.6 × 10−4).ConclusionGenetic markers of RA susceptibility located within HLA–DRB1 determine the levels of clinical and systemic inflammation independently, and also determine all objective measures of disease activity and outcome.
Effect of amino acid substitution in the hydrophobic face of amphiphilic peptides on membrane curvature and perturbation: N‐terminal helix derived from adenovirus internal protein VI as a model
Authors: Murayama Tomo , Pujals Sílvia , Hirose Hisaaki , Nakase Ikuhiko , Futaki Shiroh 
Published: June 2016

ABSTRACTThe N‐terminal amphipathic helical segment of adenovirus internal protein VI (AdVpVI) plays a critical role in viral infection. Here, we report that the peptide segment corresponding to AdVpVI (positions 33–55) can induce positive membrane curvature together with membrane perturbation. The enhanced perturbation ability of the peptide was observed for membranes containing negatively charged phospholipids. Based on the liposome leakage assay, substitution of leucine at position 40 to other aliphatic (isoleucine) and aromatic (phenylalanine and tryptophan) residues yielded a similar degree of membrane perturbation by the peptides, which was considerably diminished by the substitution to glutamine. Further studies using the wild‐type AdVpVI (33–55) (WT) and phenylalanine‐substituted peptides (L40F) demonstrated that both peptides have positive membrane‐curvature‐inducing ability. These peptides showed higher binding affinity to 50‐nm large unilamellar vesicles (LUVs) than to 200‐nm LUVs. However, no enhanced perturbation by these peptides was observed for 50‐nm LUVs compared to 200‐nm LUVs, suggesting that both the original membrane curvature and the additional strain due to peptide insertion affect the membrane perturbation ability of these peptides. In the case of L40F, this peptide rather had a lower membrane perturbation ability for 50‐nm LUVs than for 200‐nm LUVs, which can be attributed to possible shallower binding of L40F on membranes. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 430–439, 2016.
A scoping review of the nurse practitioner workforce in oncology
Authors: Coombs Lorinda A. , Hunt Lauren , Cataldo Janine 
Published: June 2016

AbstractThe quality of cancer care may be compromised in the near future because of work force issues. Several factors will impact the oncology health provider work force: an aging population, an increase in the number of cancer survivors, and expansion of health care coverage for the previously uninsured. Between October 2014 and March 2015, an electronic literature search of English language articles was conducted using PubMed®, the Cumulative Index to Nursing and Allied Health Sciences (CINAHL®), Web of Science, Journal Storage (JSTOR®), Google Scholar, and SCOPUS®. Using the scoping review criteria, the research question was identified “How much care in oncology is provided by nurse practitioners (NPs)?” Key search terms were kept broad and included: “NP” AND “oncology” AND “workforce”. The literature was searched between 2005 and 2015, using the inclusion and exclusion criteria, 29 studies were identified, further review resulted in 10 relevant studies that met all criteria. Results demonstrated that NPs are utilized in both inpatient and outpatient settings, across all malignancy types and in a variety of roles. Academic institutions were strongly represented in all relevant studies, a finding that may reflect the Accreditation Council for Graduate Medical Education (ACGME) duty work hour limitations. There was no pattern associated with state scope of practice and NP representation in this scoping review. Many of the studies reviewed relied on subjective information, or represented a very small number of NPs. There is an obvious need for an objective analysis of the amount of care provided by oncology NPs.
Sorafenib treatment in children with relapsed and refractory neuroblastoma: an experience of four cases
Authors: Okada Keiko , Nakano Yoshiko , Yamasaki Kai , Nitani Chika , Fujisaki Hiroyuki , Hara Junichi 
Published: June 2016

AbstractMetastatic neuroblastoma is an aggressive malignancy with a poor prognosis. Recent findings have shown that sorafenib decreases cell viability and increases apoptosis in human neuroblastoma cell lines. We report an experience of compassionate use of sorafenib in children with treatment‐refractory neuroblastoma. Sorafenib showed transient anti‐tumor activity in all four patients without adverse effects. However, progression was observed after a short stabilization phase. While sorafenib showed minimal anti‐tumor activity in our patients, it might still be effective in patients with neuroblastoma in an earlier stage.
Investigations on the Antimony Promotional Effect on CeO2–WO3/TiO2 for Selective Catalytic Reduction of NOx with NH3
Authors: Yan Lijun , Liu Yangyang , Hu Hang , Li Hongrui , Shi Liyi , Zhang Dengsong 
Published: June 2016

AbstractAntimony‐doped CeO2–WO3/TiO2 catalysts were prepared by a conventional ultrasonic‐assisted impregnation method and employed for selective catalytic reduction of NOx with NH3 at low temperature. Both experimental work and theoretical studies were employed to elucidate the effect of the antimony on promoting the CeO2–WO3/TiO2 catalyst. The catalytic activity of CeO2–WO3/TiO2 was largely improved after the addition of antimony oxide. It was found that antimony doping reduced the crystal size and strengthened the synergistic effect between the metal cations, which resulted in a favorable catalyst surface status with abundant active surface oxygen, Brønsted acid sites, and effective electron transfer. Both in situ diffuse reflectance infrared Fourier transform analysis and DFT calculation results revealed that the ammonia and NOx desorption behavior over the catalyst surface were considerably different. For the ammonia species, rather large amounts of the active NH4+ and NH3 species anchored on the surface of the Sb‐doped CeO2–WO3/TiO2. In view of the NOx species, the amount of nonactive bidentate nitrate species was largely reduced and the amount of active gaseous NO2 species was clearly enhanced, which lowered the activation energy of the catalytic process and gave rise to the elevated low‐temperature NH3 selective catalytic reduction activity. All these preferable properties resulted in the elevated de‐NOx activity of the Sb‐doped CeO2–WO3/TiO2 catalyst.
Social media integration in electronic human resource management: Development of a social eHRM framework
Authors: Arjomandy Danial 
Published: June 2016

AbstractSocial media has dramatically changed how we communicate both in life and in business. Accordingly, I conducted a qualitative analysis of electronic Human Resource Management (eHRM) practices involving social media. The sample consists of 16 organizations varying in size (e.g., Fortune 500 vs. small enterprises), industry (e.g., product vs. service‐based) and sector (public vs. private). Based on the review, I developed a Social Participation Framework involving two dimensions—openness and stratification— that are reflective of variations in the user domains associated with a given application. The combination of these dimensions yielded four alternative models of social media eHRM implementations: open, internal, specialized, and segmented. These in turn tended to be associated with different types of eHRM goals. A best practice example of each model is provided, and opportunities for future research are identified. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd.
A High‐Voltage and High‐Capacity Li1+xNi0.5Mn1.5O4 Cathode Material: From Synthesis to Full Lithium‐Ion Cells
Authors: Mancini Marilena , Axmann Peter , Gabrielli Giulio , Kinyanjui Michael , Kaiser Ute , Wohlfahrt‐Mehrens Margret 
Published: June 2016

AbstractWe report Co‐free, Li‐rich Li1+xNi0.5Mn1.5O4 (0<x<1) compounds as high‐voltage and high‐capacity cathode materials for Li‐ion cells. Their tailored morphology allows high density and facile processability for electrode development. In the potential range 2.4–4.9 V, the cathode material of composition Li1.5Ni0.5Mn1.5O4 shows excellent performance in terms of capacity and cycling stability in half‐cells. In addition, for the first time, we demonstrate the application of the high‐voltage and high‐capacity cathode in full Li‐ion cells with graphite anodes with very high cycling stability. The electrochemical performance and low cost of the cathode material, together with the feasibility of a chemical method to obtain Li‐rich Li1+xNi0.5Mn1.5O4 (0<x<1), make practical applications of high‐energy density Li‐ion batteries possible.