bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salmonella typhimurium infection in total knee arthroplasty: A case report with review of literature
Authors: Sebastian Sujeesh , Dhawan Benu , Malhotra Rajesh , Gautam Deepak , Kapil Arti 
Published: June 2017

Abstract
Salmonella enterica serotype Typhimurium is a rare cause of prosthetic joint infection (PJI). The recognized predisposing risk factors for Salmonella septic arthritis include diabetes mellitus, renal failure, human immunodeficiency virus infection and chronic corticosteroid use. We describe a case of PJI of the knee in a 74-year-old lady who was on antitubercular treatment. The patient presented with discharging sinus and raised inflammatory markers. She was successfully treated by the removal of prosthesis and debridement followed by ciprofloxacin therapy for 6 weeks. This case report highlights the potential virulence of Salmonella in immunocompromised patient with a joint prosthesis. Continuous monitoring and close collaboration of microbiologists and orthopedicians helped obtain the resolution of infection in our patient.
Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
Authors: Grover Sumit , Dhiman Amit Kumar , Garg Bhavna , Sood Neena , Narang Vikram 
Published: June 2017

AbstractAplastic anemia (AA) is nowadays considered to be a clonal disorder arising from a defective hematopoietic stem cell developing after a generalized insult to bone marrow. Immunosuppressive treatment (IST) of AA causes suppression of the target dominant population of haematopoietic cells allowing the defective non targeted clones to expand. This may give rise to acute leukemia. Cytogenetic studies for chromosomal aberrations such as trisomy and monosomy may help in detecting such conversions. We present a case of acquired AA in a 60-year-old male presenting with pancytopenia and hypoplastic marrow treated with antithymocyte globulin, converting into myelodysplastic syndrome and later on acute promyelocytic leukemia after being in remission for 4 years. The patient was found to have trisomy 8 on fluorescence in situ hybridization and karyotyping.
Comparison of bone marrow aspiration cytology with bone marrow trephine biopsy histopathology: An observational study
Authors: Gilotra Meenu , Gupta Monika , Singh Sunita , Sen Rajeev 
Published: June 2017

Abstract
INTRODUCTION: Bone marrow examination is a useful investigative tool for the diagnosis of many hematological and nonhematological disorders. Bone marrow aspiration (BMA) provides information about the numerical and cytological features of marrow cells, whereas bone marrow trephine biopsies (BMB) provide excellent appreciation of spatial relationships between cells and of overall bone marrow structure. We conducted this study with the objective of comparing the accuracy of BMA with BMB in the diagnosis of various hematological disorders.
MATERIALS AND METHODS: Both BMA and BMB were performed on a total of 130 cases and a comparative evaluation was performed in 100 cases to see the complementary role of both the procedures. However, 30 cases were excluded due to inadequate BMA, BMB, or both. Immunohistochemistry (IHC) was employed whenever required.
RESULTS: In our study of 100 cases, 87% of cases were confirmed on bone marrow biopsy and in remaining 13% of cases final diagnosis was achieved with the help of other ancillary investigations. These cases were excluded for calculation of concordance rate between BMA and BMB. The concordance and disconcordance rate between BMA and BMB was 72.4% and 27.6%, respectively.
CONCLUSION: BMA cytology and trephine biopsy histopathology complement each other and the superiority of one method over the other depended on the underlying disorder. Furthermore, application of ancillary techniques such as flow cytometery and IHC proved to be an additional advantage in further typing of various diseases.
Current mycological profile of onychomycosis in Kashmir valley: A hospital-based study
Authors: Asifa Nazir , Farhath Kanth 
Published: June 2017

Abstract
INTRODUCTION: Onychomycosis is a common nail ailment associated with significant physical and psychological morbidity. It is caused by dermatophytes, nondermatophytic molds, and yeasts. Increased prevalence in the recent years is attributed to enhanced longevity, comorbid conditions such as diabetes, avid sports participation, and emergence of HIV.
AIMS AND OBJECTIVES: This study was undertaken to identify the mycological profile and etiological agents associated with this infection.
MATERIALS AND METHODS: One hundred and twenty-nine cases of clinically suspected onychomycosis were included in this study. Clinical patterns were noted, and samples collected from most severely affected nail. They were subjected to direct microscopy and culture.
RESULTS: The microscopic and/or culture examination was positive in 64.34% of cases. The most common clinical type was distal lateral subungual onychomycosis in 42 (50.60%) Candida sp. was the most common fungal agent among yeasts, followed by Trichophyton sp among dermatophytes and Aspergillus among nondermatophytic molds. Females were affected more than males and fingernails were affected more frequently than toenails.
CONCLUSION: Onychomycosis is a significant and important disease which can cause many physical, physiological, and occupational problems, considerably impairing patient quality of life. Hence, fungal cultures are of paramount importance in all suspected cases of onychomycosis because the antifungal agent with an appropriate spectrum of activity can only be used if the underlying fungal pathogen is identified correctly.
Denominatie van de school, gezins- en schoolsamenstelling en onderwijsprestaties
Authors: Driessen Geert , Agirdag Orhan , Merry Michael 
Published: June 2017

Abstract

School denomination, family and school composition, and educational achievement: Are there differences between religious and non-religious schools?

Despite an ever increasing process of secularization in Dutch society, the share of religious schools in the Netherlands has remained remarkably stable over the last fifty years. One explanation for this persistent attraction among parents is the sector’s good reputation regarding educational quality and achievement. This study tests whether this assumption corresponds with empirical reality. The data analyzed come from the second measurement round of the COOL5-18 cohort study conducted in 2011. A total of 19 cognitive and non-cognitive outcome measures were available from 27457 students in grades 2, 5 and 8 of 386 primary schools. The analyses compare the outcomes of public (i.e. neutral) schools with those of three types of religious schools, namely Protestant, Catholic, and Islamic schools. The results show that after controlling for differences between students in terms of social and ethnic background, and schools in terms of share of low educated and immigrant parents, no differences between public and religious schools remain. Meanwhile, Islamic schools appear to have a special potential regarding the elimination of their educational disadvantage.
Emancipatiebeleid tussen geleefde droom en onvoltooide daad
Authors: Schippers Joop 
Published: June 2017

Abstract
The author also comments on the interview with D’Ancona and Bussemaker. He enumerates the similarities between them: their enthusiasm and their struggles to ‘frame’ the problem of emancipation in a correct way. Both make a distinction between the substance and the process of emancipation policy, making it all the more surprising, he argues, that so little has been done in the past years to establish new institutions and to generate continuity. Lack of consensus between political parties about the way forward has generated an incremental way of policy making, resulting in a patchwork of regulations, which are often very confusing to the public. Schippers, furthermore, draws attention to the differences between the interviewees in view of the work/care problem – sharing between partners or stimulating the commercialisation of care work.
Femtosecond Laser-Assisted Cataract in Vitreoretinal Surgery
Authors: Rizzo Stanislao , Bacherini Daniela , Faraldi Francesco , Pellegrini Marco , Mariotti Cesare 
Published: June 2017

Purpose To assess the safety and surgical results of femtosecond laser-assisted phacovitrectomy. Methods Fifteen patients over 50 years of age with coexisting vitreoretinal pathologies and cataract underwent combined femtosecond laser-assisted cataract extraction and sutureless 25-G and 27-G vitreoretinal surgery. Results The indication for surgery was macular hole in 6 patients, epiretinal membrane in 6, vitreous hemorrhage in 2, and retinal detachment in 1. The mean preoperative best-corrected visual acuity (BCVA) was 0.64 ± 0.23 logMAR and the mean postoperative BCVA was 0.19 ± 0.11 logMAR. In 4 patients with epiretinal membrane with corneal astigmatism of 3.35 ± 0.32 D as mean value, a toric intraocular lens (IOL) was implanted: mean residual refractive cylinder was 0.47 ± 0.23 D. Three months postoperatively, mean IOL rotation was 1.64 ± 0.28°. All patients improved their visual acuity. The intraoperative complications of femtosecond laser were 1 subconjunctival hemorrhage, 1 case of miosis, and 1 suction loss. The surgeon was able to maintain a clear view of the retina at all times. After surgery, a better fundus examination was possible with no capsular opacification. Mean follow-up was 6 months. Conclusions Femtosecond laser cataract in vitreoretinal surgery appears a safe and effective technique with potential benefits: the precision and centration of the capsulorhexis may potentially reduce the risk of IOL prolapse into the anterior chamber in gas-filled eyes. Implantation of the toric IOL was effective in reducing preexisting corneal astigmatism and provided good rotational stability and refractive outcome.
Optic Disc Pit Maculopathy after Prone Positioning Spine Surgery
Authors: Ruiz-Sánchez Marcos , Rodríguez-González-Herrero Maria E. , Ruiz-Sará Jenifer 
Published: June 2017

Purpose To report a case of optic disc pit maculopathy after spine surgery performed in the prone position. Methods Case report. Results A 32-year-old man underwent spine surgery for disc herniation repair. He complained of visual acuity loss immediately after the procedure. Optic disc maculopathy with internal limiting membrane detachment was found to be the cause. Vitrectomy was scheduled after a 12-month follow-up without resolution of the maculopathy. Conclusions Optic disc maculopathy has not previously been associated with nonocular surgery or patient positioning. Physiologic changes induced by the prone position likely altered the pressure gradient in the eye and led to the development of the maculopathy.
Anemia after Continuous-flow Left Ventricular Assist Device Implantation: Characteristics and Implications
Authors: Amione-Guerra Javier , Cruz-Solbes Ana S. , Bhimaraj Arvind , Trachtenberg Barry H. , Pingali Sai R. , Estep Jerry D. , Park Myung H. , Guha Ashrith 
Published: June 2017

Background Anemia is common in patients with heart failure and is associated with adverse outcomes. Management of anemia in CF-LVAD patients is not well studied. Our purpose is to characterize and identify the etiology of anemia in CF-LVAD patients. Secondary objectives are to describe the effect of CF-LVAD on pre-existing anemia and assess its impact after CF-LVAD support. Methods Cross-sectional study from January to July 2015 of ambulatory patients supported with a CF-LVAD for at least 6-months that presented with hemoglobin <12 g/dL and no recent gastrointestinal bleeding. Patients were classified as iron-deficient and non-iron-deficient and compared. Additionally, a retrospective analysis of 116 consecutive patients who underwent CF-LVAD from 2008 to 2013 with reported hemoglobin at 6 months as outpatients were divided into anemic or non-anemic and compared. Results In our cross-sectional cohort, iron deficiency was the most common cause of anemia. Notably, 49% of the iron-deficient patients were already on iron supplementation. In our retrospective cohort, 59% of the patients were anemic after 6 months of support. Anemic patients were older, had lower albumin, higher brain natriuretic peptide (BNP), worse renal function and New York Heart Association (NYHA) class. Anemia had a HR of 3.16 (95%CI 1.38–7.26) to predict a composite of 1-year death and HF readmissions, as well as HF-readmissions alone. Conclusions The most common cause of anemia in our study was iron-deficiency; almost half of the patients were iron deficient despite treatment, suggesting that oral iron may not be sufficient to reverse anemia. Anemia regardless of etiology was associated with adverse outcomes.
Association of N-acetyltransferase 1 Polymorphism and Bladder Cancer Risk: An Updated Meta-analysis and Trial Sequential Analysis
Authors: Xu Zicheng , Li Xiao , Qin Zhiqiang , Xue Jianxin , Wang Jingyuan , Liu Zhentao , Cai Hongzhou , Yu Bin , Xu Ting , Zou Qin 
Published: June 2017

Background Individual studies of the association between N-acetyltransferase 1 (NAT1)*10 allele and bladder cancer susceptibility have shown inconclusive results. To derive a more precise estimation of any such relationship, we performed this systemic review and updated meta-analysis based on 17 publications. Methods A total of 17 studies were investigated with 4,322 bladder cancer cases and 4,944 controls. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Subgroup analyses were conducted based on ethnicity, sex, source of controls and detecting methods. Then trial sequential analysis was performed to evaluate whether the evidence of the results was sufficient and reduce the risk of type I error. Results There was no association between NAT1*10 allele and bladder cancer risk in a random-effects model (OR = 0.96, 95% CI, 0.84-1.10) or in a fixed-effects model (OR = 0.95, 95% CI, 0.87-1.03). In addition, no significantly increased risk of bladder cancer was found in any other subgroup analysis. Then, trial sequential analyses demonstrated that the results of our study need to be further verified. Conclusions Despite its limitations, the results of the present meta-analysis suggested that there was no association between NAT1* 10 allele and bladder cancer risk. More importantly, our findings need to be further validated regarding whether being without the NAT1*10 allele could in the future be shown to be a potential marker for the risk of bladder cancer.
Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors
Authors: Tian Guang-Wei , Li Nan , Xin Yan 
Published: June 2017

Background Colon cancer–associated transcript 2 (CCAT2) as a long noncoding RNA (IncRNA) is overexpressed and plays a significant prognostic role in patients with tumors. The present study aimed to comprehensively evaluate the clinical value of CCAT2 in the Chinese population, as a potential prognostic marker in multiple cancers. Methods A systematic search of eligible studies was conducted in the PubMed, Web of Science, Cochrane Library, Wanfang and the China National Knowledge Infrastructure databases as of March 31, 2017. Approximately 1,711 tumor patients from 16 eligible studies were selected. Analyses of the pooled data were performed, and the odds ratio (OR) or hazard ratio (HR) and the 95% confidence interval (95% CI) were calculated and summarized to evaluate the strength of this association using a fixed- or random-effects model. Results Overall analyses showed that increased CCAT2 expression was associated with a higher risk of lymph node metastasis (LNM), an increased potential for distant metastasis (DM) and higher clinical stage (p<0.001 for LNM, p = 0.001 for DM, p<0.001 for clinical stage). HR and the 95% CI for overall survival (OS) were assessed to pool the effect size using a fixed-effects model. A significant association was observed between increased CCAT2 expression and poor OS (pooled HR = 1.91, 95% CI, 1.63-2.22, p<0.001). Conclusions These results indicate that CCAT2 is a biomarker to predict tumor progression and a potential prognostic marker in multiple cancers. Additional well-designed clinical studies are needed to validate these findings.
Biodegradable intramedullary nails reinforced with carbon and alginate fibers: In vitro and in vivo biocompatibility
Authors: Morawska-Chochół Anna , Domalik-Pyzik Patrycja , Menaszek Elżbieta , Sterna Jacek , Bielecki Wojciech , Bonecka Joanna , Boguń Maciej , Chłopek Jan 
Published: June 2017

Background: Commonly, intramedullary nails are made of nondegradable materials, and hence they need to be removed once the bone fracture is healed. We propose a novel composite material consisting of poly-L-lactide matrix modified with carbon and alginate fibers to be used for biodegradable intramedullary fixation. The aim of this study was to make in vitro and in vivo biocompatibility assessments. Methods: In the in vitro conditions, biocompatibility of biomaterials was compared using normal human osteoblasts. After 3 and 7 days, cytotoxicity, viability and proliferation tests were performed, as well as cell morphology and adhesion observations. In the in vivo experiments, Californian rabbits (approx. 9 months old) were used. The composite nails and controls (Kirschner wires) were used for fixation of distal femoral osteotomy. The evaluation was made on the basis of clinical observations, radiographs taken after 2, 4, 6 and 8 weeks post implantation, and macroscopic and histological observations. Results: Cell tests indicated that both modifiers had a positive influence on cell viability. Biodegradable composite nails led to bony union when used for fixation of distal diaphysis osteotomy in rabbits. Histological analysis showed that the initial focal necrosis should be fully compensated for by the osteoblast proliferation and trabeculae formation. Conclusions: Both in vitro and in vivo tests confirmed biocompatibility and potential applicability of novel biodegradable intramedullary nails modified with long carbon and alginate fibers for osteosynthesis of bone epiphysis.
The Familial Risk of Endometriosis among the Female Relatives of Patients with Endometriosis in Greece
Authors: Matalliotakis Michail , Goulielmos George N. , Zervou Maria I. , Matalliotaki Charoula , Koumantakis Georgios , Matalliotakis loannis 
Published: June 2017

Introduction Endometriosis is a gynecologic disease affecting up to 10% of the women and a major cause of pain and infertility. It is a complex genetic disease with an overall heritability estimated at around 4%. We aimed to study the familial risk of endometriosis among the female relatives of patients with endometriosis. Furthermore, we compared the demographic variable characteristics of patients with and without family history of endometriosis. Methods We evaluated the medical reports of 400 women with endometriosis and 400 without, all of whom underwent consultation for infertility or pelvic pain and had surgery between 2002 and 2016. This retrospective study was conducted in the Obstetrics and Gynecology Department of Venizeleio General Hospital of Heraklion, Crete. Data were collected from patients' charts and analyzed by statistical methods including x2 and Mann-Whitney U test. Results The overall risk of first-degree relatives of endometriosis was 10.2% versus only 0.7% of controls p<0.001. Among 25 pairs of sisters we found one or more sisters with endometriosis. Additionally, we reported a family with six members with endometriosis within three generations. In women with positive family history of endometriosis we observed earlier menarche and more severe stage of endometriosis. Moreover, we did not notice any difference in the demographic characteristics between the endometriosis and the control group patients; similar clinical data was observed in both groups. Conclusions These data support the view that genetic factors play a role in the development of this condition.
Validity of the PROMIS-29 in a large Australian cohort of patients with systemic sclerosis
Authors: Morrisroe Kathleen , Stevens Wendy , Huq Molla , Sahhar Joanne , Ngian Gene-Siew , Zochling Jane , Roddy Janet ,   the Australian Scleroderma Interest Group (ASIG), Proudman Susanna , Nikpour Mandana 
Published: June 2017

Background We aimed to evaluate the construct validity of the Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29) in Australian systemic sclerosis (SSc) patients. Methods SSc patients, identified through the Australian Scleroderma Cohort Study database, completed two quality-of-life instruments concurrently, the PROMIS-29 and the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36). The construct validity of the PROMIS-29 was assessed by the correlations between the PROMIS-29 and the SF-36 and Health Assessment Questionnaire Disability Index (HAQ-DI). Cronbach's alpha was used to test the internal reliability of all instruments in Australian SSc patients and non-parametric correlation, including Spearman's correlation, was used to test the construct validity of PROMIS-29 against the SF-36 and HAQ-DI. Results A total of 477 completed questionnaires were returned, equating to a response rate of 59.6%. The mean (±SD) age of respondents at the time of the survey was 64.1 (±11.1) years. They were predominantly female (87.4%), with limited disease subtype (lcSSc) (77.8%) and long disease duration from onset of first non-Raynaud's phenomenon symptom at the time of survey (10.9 ± 11.1 years). For the correlation analysis between the PROMIS-29 and the legacy instruments, all Spearman correlation coefficients were in the logical direction and highly significant suggesting that the PROMIS-29 is a good alternative to other validated measures of disease burden. Conclusions Our study indicates that the PROMIS-29 questionnaire is a valid instrument for measuring health-related quality of life in Australian females with lcSSc of long duration.
Efficacy of statin on vascular access patency in diabetic hemodialysis patients
Authors: Sanada Satoru , Miyasaka Yasunori , Kanno Atsuhiro , Sato Kozo , Sato Mitsuhiro , Sugai Hisako , Kitamura Hiroshi , Sato Toshinobu , Taguma Yoshio 
Published: June 2017

Introduction An effective approach to prevent hemodialysis vascular access dysfunction is still unclear despite previous studies, which have shown conflicting results of several drugs on vascular access outcomes. In this study, we focused on diabetic hemodialysis patients with native arteriovenous fistula and evaluated the impact of statin treatment on vascular access patency. Methods A retrospective cohort study of 268 consecutive patients who newly started hemodialysis due to diabetic nephropathy between January 2011 and December 2013 at Japan Community Health Care Organization Sendai Hospital was performed and the patients were followed for two years. The primary outcome was vascular access dysfunction. Effect of statin treatment was examined using Kaplan Meier analysis and Cox proportional hazard, after adjusting for covariates. Results The mean follow-up period was 426.7 days, and 117 (52.2%) patients developed vascular access dysfunction. The two-year patency rate was 55.0% among statin users and 36.1% in non-users. Vascular access survival period was significantly longer among statin users (log-rank test, p = 0.004). In multivariable analysis, statin treatment is significantly associated with better vascular access outcomes, in which the hazard ratio was 0.71 (95% CI, 0.52 to 0.97; p = 0.028) in the unadjusted model and 0.63 (95% CI, 0.45 to 0.88; p = 0.007) after adjustment for covariates. Conclusions Statin treatment could be associated with improved vascular access dysfunction among diabetic hemodialysis patients.