bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization
Authors: Aggarwal Anu , Josyula Vara Prasad VN , Wang Nancy , Yang Moua , Shim Young Jun , Kennedy Quinn P. , Samuel Reina , Sangwan Naseer , Guntupalli Suman , Godwin Matthew , Ali Mariya , Jennings Courtney , Rajasekar Bhairavi , Scalise Alliefair , Park Huijun Edelyn , Stauffer Shaun , McCrea Keith , McIntyre Thomas , Cameron Scott J. 
Published: October 2024

AbstractBackgroundDespite antiplatelet therapy, some patients remain at high risk for ischemic events due to medication non-responsiveness or High Residual Platelet Reactivity (HRPR). Our goal was to target an orphan G-Protein-Coupled Receptor (GPCR) on platelets belonging to the olfactory receptor family as a new antithrombotic strategy.MethodsUsing an engineered reporter cell line expressing Olfactory Receptor 2L13 (OR2L13) that was recently identified as an orphan GPCR to limit platelet reactivity, we performed a high-throughput screen (HST) of non-odorant bioactive compounds with counter-screen validation, followed by studies to determine changes in platelet function in healthy subjects and in patients with coronary artery disease and peripheral artery disease. Phospho-proteomics identified key signal transduction pathways, and a variety ofex vivoassays andin vivofunctional studies examined the impact of an identified non-odorant compound on platelet signaling, platelet biomechanics, and thrombosis.ResultsWe identified 6 ligands specific for OR2L13 that function as receptor agonists, leading to the suppression of platelet aggregation and α-granule exocytosis via P2Y12,PAR1, Thromboxane Receptor (TxR) and glycoprotein VI (GPVI) receptors, suggesting involvement of common downstream mediator. The lead OR2L13 agonist identified phosphorylates heat shock protein 27 (HSP27) and depolymerizes the platelet filamentous actin cytoskeleton which was further confirmed in a clot retraction assay (CCF0054500 clot area 70.6 vs. vehicle clot area 5.2, P<0.0001). This anti-thrombotic effect of the OR2L13 agonist was reversed by a HSP27 inhibitor (clot area 3.6, P<0.0001). In a murine cremaster arterial injury model, platelet accumulation at the injury site was reduced by 88.9% by the lead OR2L13 agonist compared to vehicle (P<0.0003) without altering fibrin generationin vivo, or interfering with the coagulation cascade, and without impairing the protective mechanism of platelet hemostasis.ConclusionWe describe and characterize the first non-olfactory tool to target an olfactory receptor for the purpose of inhibiting platelet activation and thrombosis through downstream HSP27 in a comprehensive investigation using a first-of-its kind platelet inhibitor targeting an orphan platelet GPCR.
IQD2 recruits KLCR1 to the membrane-microtubule nexus to promote cytoskeletal mechano-responsiveness in leaf epidermis pavement cells
Authors: Buhl Jonas , Klemm Sandra , Kölling Malte , Ruhnow Felix , Ihling Christian , Tüting Christian , Dahiya Pradeep , Patzsch Jacqueline , Colin Leia , Stamm Gina , Sinz Andrea , Kastritis Panagiotos L. , Persson Staffan , Bürstenbinder Katharina 
Published: October 2024

SummaryPlant cells experience a variety of mechanical stresses from both internal and external sources, including turgor pressure, mechanical strains arising from heterogeneous growth between neighboring cells, and environmental factors like touch from soil, rain, or wind [1,2]. These stresses serve as signals at the cell-, tissue- and organismal level to coordinate plant growth during development and stress responses [3]. In plants, the physical cell wall-plasma membrane-microtubule continuum is proposed to be integral in transducing mechanical signals from the exterior to intracellular components [4–6]. Cortical microtubules (CMTs) rapidly reorient in response to mechanical stress to align with the maximal tensile stress direction [7,8]. Several studies proposed that CMTs themselves may act as stress sensors; the precise mechanisms involved in the regulation of CMTs and the modes of sensing, however, are still not clearly understood. Here, we show that IQD2 and KLCR1 are enriched at CMTs in proximity to the plasma membrane. IQD2, which is abona fidemicrotubule-associated protein, promotes microtubule localization of KLCR1. By combining cross-linking mass spectrometry (XL-MS) and computational modeling with structure-function studies, we present first experimental insights into the composition and structure of IQD2-KLCR1 complexes. Further, we demonstrate that the IQD2-KLCR1 module is a positive regulator of microtubule mechano-responses in pavement cells. Collectively, our work identifies the IQD2-KLCR1 module as novel regulator of mechanostress-mediated CMT reorientation and provides a framework for future mechanistic studies aimed at a functional dissection of mechanotransduction at the plasma membrane-CMT interface during growth and plant morphogenesis.HighlightsIQD2 and KLCR1 localize to the plasma membrane-microtubule nexusIQD2 is required for efficient microtubule targeting of KLCR1in plantaIQD2 physically interacts with KLCR1 and microtubulesThe IQD2-KLCR1 module promotes mechano-stress induced microtubule reorganization
Climate change literacy objectives for construction professionals in Zimbabwe
Authors: James Mellinda , Moyo Tirivavi , Moyo Cynthia 
Published: September 2024

PurposeConstruction professionals' literacy incapacity exacerbates their vulnerability to climate change hazards on construction projects. Therefore, this study sought to determine climate change literacy objectives for Zimbabwean construction professionals. Climate change-literate construction professionals can significantly strengthen resilience and adaptive capability within the built environment.Design/methodology/approachThe positivist approach employed a cross-sectional questionnaire survey strategy to collect quantitative data from construction professionals (Architects, Civil/Structural engineers, Project managers and Quantity surveyors) working in 280 registered consultancy and construction firms in Zimbabwe. The data were analysed using mean scores, normalisation, Kruskall–Wallis tests and factor analysis.FindingsThe respondents’ perceptions of the most critical climate change literacy objectives included knowledge of sustainable material utility, designing for resilient structures and understanding how climate change affects workers' physical and mental well-being. Generally, consensus on the nature of climate literacy objectives was evident. The factor analysis determined three components: stakeholder and climate information-related interventions, carbon and environmental footprint-related literacy and climate systems and indigenous knowledge-related literacy. Construction professionals can interpret climate change information through the determined objectives, contribute to reducing carbon and environmental footprint and improve project outcomes.Research limitations/implicationsA limitation was that a quantitative method was only employed; a concurrent qualitative inquiry could have mined more diverse views. Professional bodies and tertiary institutions can design climate change programmes based on the determined climate change literacy objectives for construction professionals.Originality/valueThe study determined climate change literacy objectives for construction professionals in Zimbabwe to enable them to respond to climate change hazards.
Leading from a distance: nurturing trust in virtual and crisis environments
Authors: Gamage Ancy , Muchiri Michael , Shahid Sehrish , Rashid Tanzil 
Published: September 2024

PurposeThis study draws on the Social Process of Leadership (SPL) to identify the necessary behavioural leadership characteristics for trust-building in virtual crisis environments.Design/methodology/approachThe study employs an in-depth qualitative case-study approach that is embedded in local contexts. Multiple sources of data – organisational documents, in-depth qualitative interviews, observational evidence and field notes – were used in the study. Interviews were informed by a purposeful sampling strategy and were semi-structured. This allowed the interviewer to use prompts to follow up with unanticipated issues raised by participants. Thematic analysis was conducted using NVivo.FindingsThree key themes (related to how leaders nurture trust in virtual and crisis contexts) emerged from the data. These relate to nurturing trust by (1) optimising and providing a clear vision through reconfigured and personalised communication structures; (2) minimising uncertainty, optimising and modelling values-based behaviours and (3) enhancing adaptability and performance.Research limitations/implicationsThe study extends the applicability of this theoretical approach to remote workplaces. It also contributes to the literature on crisis leadership by showcasing how leaders’ crisis responses based on SPL help organisations navigate disruptions. Limitations regarding the small sample size and the one case study context exist.Practical implicationsOrganisations should invest in leadership and resilience and build strong remote/hybrid working models in preparation for future crises.Originality/valueDespite the growing popularity of SPL, there is limited work on how leaders implement SPL processes to build and maintain trust in virtual workplaces. Furthermore, SPL has not yet been applied in highly disruptive work contexts, like those created by the pandemic.
The contribution of organic private label products to private label share outcomes
Authors: Hoskins Jake , Konuk Faruk Anıl , Machin Jane Emma 
Published: September 2024

Purpose
The growing demand for sustainable consumption motivates retailers to consider including organic private label products in private label assortments to attract and serve health and environmentally conscious consumers, while also possibly improving the image of the private label brand as well. This study aims to examine the impact of prioritizing organic private label products in private label assortments on private label share outcomes.

Design/methodology/approach
Theoretical predictions are empirically examined using a comprehensive store panel sales data set covering 50 distinct metropolitan markets in the USA from 2008 to 2011 in the yogurt product category.

Findings
Findings indicate that private label products may provide strategic value for certain retailers, based on a variety of private label assortment, national brand competition and retailer characteristic dimensions.

Research limitations/implications
This research serves as initial empirical evidence on how organic products may influence private label category share. Future research should consider additional product categories and geographic markets and also seek to understand consumer perceptual factors in more detail.

Practical implications
Retail managers can better understand the role that organic products play in private label portfolios.

Originality/value
While much previous work has examined how organic products sell relative to conventional products and a sizable literature has investigated private label brand strategy, little research has explicitly examined the role of organic products within private label assortments.
The impact of attention and task performance on antiphishing performance: a multigoal perspective
Authors: Pan Shihe , Kuem Jungwon 
Published: September 2024

PurposePeople are often recognized as the weakest part of thwarting phishing attacks. The goal of preventing phishing can conflict with the goal of keeping a good level of productivity in daily work; however, we still lack an understanding of this multigoal scenario. This paper aims to develop and test a new model of antiphishing performance, especially in relation to individuals' task performance in daily work. Drawing on the extended multiple-goal pursuit model (MGPM*), we examined the relationship between task performance at a time point and the subsequent antiphishing performance as well as how this relationship differs across varying types of phishing emails and attention levels to phishing cues.Design/methodology/approachWe tested the model by conducting a field experiment with a survey questionnaire. Four legitimate work emails and four phishing emails (consisting of two work-related and two work-unrelated emails) were sent to 357 participants. The data were analyzed using generalized estimating equations.FindingsThe results indicate that task performance at a time point has a curvilinear relationship with subsequent antiphishing performance. This relationship is moderated by the types of phishing emails and individuals' attention to phishing cues. For work-related phishing emails, task performance is negatively associated with antiphishing performance when it reaches an intermediate level; however, when task performance is low, or high to an extent, it is positively related to antiphishing performance. For work-unrelated phishing emails, there is a positive association between task performance and antiphishing performance. Moreover, attention to phishing cues moderates the curvilinear relationship between task performance and antiphishing performance such that when task performance reaches an intermediate level, as attention to phishing cues increases, the relationship between task performance and antiphishing performance will turn from negative to positive.Practical implicationsThis paper has practical implications that bear on the conflict between antiphishing performance and task performance.Originality/valueThis paper sheds light on the potential of the extended multiple-goal pursuit model in studying antiphishing behavior.
Artificial intelligence and its applications in the context of accounting and disclosure
Authors: Al-Okaily Manaf 
Published: September 2024

Purpose
The purpose of this paper is to examine whether artificial intelligence (AI) increases data and information quality in the accounting and disclosure context.

Design/methodology/approach
Data were collected from financial managers, who are working in listed Jordanian firms in the Amman Stock Exchange. SmartPLS software based on the Partial Least Squares Structural Equation Modeling approach was used to test hypotheses.

Findings
The empirical results reached the acceptance of all hypotheses, and this means that all hypothesized relationships were positive, as the impact of AI was positive on data and information quality in the accounting and disclosure context, and also the adoption of digital disclosure mediated the relationship between AI and the quality of financial data and information, and hence, all hypotheses were statistically supported in the context of Jordan.

Originality/value
This study broadened the literature by proposing a research model that defines some of the main factors for determining financial managers’ perceptions of issues with digital financial disclosure adoption and its impact on financial data and information quality. By illuminating the relevance of these issues in the presence of the mandate of digital disclosure, this study sheds some light on digital disclosure regulators in making future policies for digital disclosure adoption among the different sectors such as financial, service and industrial in the Jordanian context.
Exploring aggressive tax planning dynamics: the impact of investment opportunity sets and free cash-flow surplus
Authors: Ghazalat Anas 
Published: September 2024

Purpose
This study aims to investigate how investment opportunity sets (IOs) and free cash-flow (FCF) surpluses affect aggressive tax planning (ATP). This research focuses on examining the correlation between these factors and delves into how ATP, perceived as a tool for exploiting legal loopholes, plays a central role.

Design/methodology/approach
This study uses panel data analysis techniques on a sample of 1,248 firm-observations gathered from nonfinancial enterprises in Jordan that are listed in the Amman Stock Exchange (ASE) between the years 2008 and 2019. The Driscoll–Kraay regression model (fixed effect) is enlisted to avoid the inconsistency of the slope across individual units and time period.

Findings
The findings indicate that the IOs does not affect ATP. However, there is a significant negative effect of FCF surplus on ATP. Furthermore, consistent with positive accounting theory the data reveal that all of these control variables exert a substantial positive influence on ATP.

Research limitations/implications
This study concentrates on nonfinancial firms listed in the ASE, thereby constraining the applicability of the results to alternative contexts. Nevertheless, the findings of this study enhance comprehension regarding the extent of ATP and bear policy implications for policymakers regarding the structuring of future tax systems aimed at reducing the prevalence of tax avoidance behaviors. Thus, future research should conduct longitudinal studies to capture temporal dynamics.

Originality/value
This study contributes to the existing literature on ATP by focusing on using the Wilson tax-shelter model as a precise proxy. It fills gaps in prior research by exploring connections between IOs, FCF and ATP. The findings offer novel insights into the dynamics of tax planning strategies and contribute to the broader understanding of tax management practices.
Discerning the state of the art in Italy of voluntary disclosure on biodiversity and endemic species
Authors: Solimene Silvia , Coluccia Daniela , Fontana Stefano , Gulluscio Carmela , Bernardo Alessandro , Carnegie Garry D. 
Published: September 2024

Purpose
This study aims to examine the extent and quality of biodiversity reporting within publicly traded companies in Italy during 2022, amidst growing calls worldwide for enhanced corporate environmental responsibility.

Design/methodology/approach
The study proposes a framework derived from existing biodiversity reporting literature and international guidelines on the topic. Using data from companies’ non-financial reports, the voluntary biodiversity disclosure index is quantified on disclosed information. Various quality reporting characteristics are also deepened. Sector-specific analysis is conducted across 11 industries.

Findings
Approximately 30% of companies in the sample release information on their biodiversity practices/initiatives regarding biodiversity and extinction loss risks. Quantitative analysis reveals a general commitment to disclosure yet falls short of optimal standards. Qualitative insights suggest a genuine intention towards reporting exists, with notable gaps in future orientation, double materiality and mitigation strategies. The quality analysis underscores that the reporting is mainly generalised, narrative and disaggregated concerning actions to restore habitats and ecosystems.

Research limitations/implications
A limitation of this study is the observation of annual reports during one reporting period. Future studies of longer duration would provide cross-period insights into corporate behaviour.

Practical implications
Policymakers should implement regulations and guidelines specifically tailored to biodiversity reporting, providing clear frameworks and standards for companies. Collaborative initiatives between governments, businesses and environmental organisations offer potential to develop best practices and facilitate knowledge-sharing in biodiversity reporting.

Social implications
Collaborative initiatives between governments, businesses and environmental organisations offer potential to develop best practices and facilitate knowledge sharing in biodiversity reporting.

Originality/value
The study contributes to future biodiversity disclosure research by introducing a comprehensive framework that fosters stakeholder trust and environmental accountability. It also sheds light on biodiversity stewardship among Italian companies, under EU directives.
Police leaders’ perspectives on their ability to support employee wellbeing in Australia: lack of time, training or support?
Authors: Sharafizad Fleur , Hernandez Grande Aglae , Farr-Wharton Benjamin 
Published: September 2024

PurposePolicing organizations in Australia are increasingly expected to eliminate or mitigate psychosocial risks in the workplace to promote employee wellbeing. New leadership skills are required, as police leaders play a key role in supporting the physical and mental health of their staff. This study aims to investigate police leaders’ perceptions about their ability to support employee wellbeing, and the ways in which they would like their organization to equip them for this important task.Design/methodology/approachQualitative thematic analysis was conducted on the narratives provided by 156 Australian police leaders in response to a series of open-ended questionnaire questions.FindingsDrawing on the conservation of resources theory, the themes identified indicate that police leaders are hindered in their ability to support the wellbeing of their staff by their own increasing workload in a context of reduced resourcing, the continuing stigma around mental health issues, a lack of knowledge and skills about how to support employee wellbeing and a lack of support from senior management.Practical implicationsOverall, the study highlights the way in which new work, health and safety guidelines place additional responsibilities on police leaders for which many report not feeling prepared. Findings suggest that bespoke leadership training may be required to assist police leaders in supporting the mitigation of psychosocial hazards in the workplace.Originality/valueConsidering continuously evolving psychosocial safety guidelines, this paper makes a unique contribution to contemporary knowledge by focusing on the role and readiness of police leaders in Australia to lessen the psychological impact of police work on officers in an increasingly complex policing context. Additionally, practical implications and recommendations are discussed and offered.
Public spending and sustainable economic development
Authors: Sama Molem C. , Oumar Saidou Baba , Ndam Nembo Leslie 
Published: October 2024

Purpose
Despite the increase in public spending by Sub-Saharan African (SSA) Governments in a bid to foster the growth of human capital and sustainable development, they continue to experience a very slow rate of progress. This study aims to investigate the impacts of public spending on sustainable economic development in SSA.

Design/methodology/approach
The study adopts the system generalized method of moments to account for cross-sectional dependence and endogeneity for 38 SSA countries from 1996 to 2019.

Findings
The findings indicate that public spending inhibits sustainable economic development while human capital enhances sustainable economic development in SSA. Furthermore, the study equally reveals that the development-inhibiting role of public spending is modulated through human capital and governance quality. Public spending interacts with human capital and governance quality to produce negative net effects and positive synergy effects, respectively.

Originality/value
Based on these findings, the study suggests that governments in SSA countries should discourage heavy dependence on public spending. Policies that provide a framework for financial incentives in the domain of health and education should be encouraged to increase investment in human capital.