bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closure Time of the Junggar‐Balkhash Ocean: Constraints From Late Paleozoic Volcano‐Sedimentary Sequences in the Barleik Mountains, West Junggar, NW China
Authors: Liu Bo , Han Bao‐Fu , Chen Jia‐Fu , Ren Rong , Zheng Bo , Wang Zeng‐Zhen , Feng Li‐Xia 
Published: November 2017

AbstractThe Junggar‐Balkhash Ocean was a major branch of the southern Paleo‐Asian Ocean. The timing of its closure is important for understanding the history of the Central Asian Orogenic Belt. New sedimentological and geochronological data from the Late Paleozoic volcano‐sedimentary sequences in the Barleik Mountains of West Junggar, NW China, help to constrain the closure time of the Junggar‐Balkhash Ocean. Tielieketi Formation (Fm) is dominated by littoral sediments, but its upper glauconite‐bearing sandstone is interpreted to deposit rapidly in a shallow‐water shelf setting. By contrast, Heishantou Fm consists chiefly of volcanic rocks, conformably overlying or in fault contact with Tielieketi Fm. Molaoba Fm is composed of parallel‐stratified fine sandstone and sandy conglomerate with graded bedding, typical of nonmarine, fluvial deposition. This formation unconformably overlies the Tielieketi and Heishantou formations and is conformably covered by Kalagang Fm characterized by a continental bimodal volcanic association. The youngest U‐Pb ages of detrital zircons from sandstones and zircon U‐Pb ages from volcanic rocks suggest that the Tielieketi, Heishantou, Molaoba, and Kalagang formations were deposited during the Famennian‐Tournaisian, Tournaisian‐early Bashkirian, Gzhelian, and Asselian‐Sakmarian, respectively. The absence of upper Bashkirian to Kasimovian was likely caused by tectonic uplifting of the West Junggar terrane. This is compatible with the occurrence of coeval stitching plutons in the West Junggar and adjacent areas. The Junggar‐Balkhash Ocean should be finally closed before the Gzhelian, slightly later or concurrent with that of other ocean domains of the southern Paleo‐Asian Ocean.
Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis
Authors: Raju Murugesan , Santhoshkumar Puttur , Sharma K. Krishna 
Published: November 2017

AbstractMany of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to facilitate the entry of a minichaperone across the cell membrane. Previous studies suggest that the minichaperone peptide representing the chaperone site in αA‐crystallin, which can inhibit protein aggregation associated with proteopathies, has therapeutic potential. A synthetic minichaperone is prepared by fusing the VPTLK sequence to N‐terminus of minichaperone (FVIFLDVKHFSPEDLTVKGRD) to get VPTLKFVIFLDVKHFSPEDLTVKGRD peptide, which is called “CPPGRD.” The amino acids, glycine–arginine–aspartic acid (GRD), are added to increase the solubility of the peptide. The chaperone‐like function of CPPGRD is measured using unfolding conditions for alcohol dehydrogenase and α‐lactalbumin. The antiapoptotic action of the peptide chaperone is evaluated using H2O2‐induced Cos‐7 and ARPE‐19 cell apoptosis assays. The results show that the CPPGRD has both chaperone function and antiapoptotic activity. Additionally, the CPPGRD is found to prevent β‐amyloid fibril formation and suppress β‐amyloid toxicity. The present study demonstrates that the CPPGRD protects unfolding proteins from aggregation and prevents cellular apoptosis. Therefore, the CPPGRD is a minichaperone with potential to become a therapeutic agent for protein aggregation diseases.
Manipulating morphology in thermoplastic protein/polyester blends for improved impact strength
Authors: Smith Matthew J. , Verbeek Casparus J. R. 
Published: November 2017

AbstractNovatein thermoplastic protein was blended with 10 wt% poly(butylene adipate‐co‐terephthalate) (PBAT) compatibilized with Joncryl ADR‐4368 and 2‐methylimidazole (2MI). Morphology was tailored for favorable impact strength through changing viscosity ratio (λ) and interfacial tension (γ12). For uncompatibilized blends, λ decreased and γ12 increased with increasing Novatein water content, whereas compatibilizers caused a decrease in both λ and γ12. PBAT continuity was high when uncompatibilized, but dispersion improved with decreasing λ and increasing γ12. The dispersed domain size decreased in all compatibilized blends; PBAT continuity was lowest in samples with the smallest λ. Compatibilized blends had higher impact strength than Novatein and uncompatibilized blends through improved interfacial adhesion, smaller domain size, and increased dispersion. By altering λ and γ12, and with appropriate chemical interaction, a morphology can be created for improved impact strength. Increasing PBAT content showed further increases in impact strength; however, a cocontinuous morphology formed, demonstrating that composition can override the effect of λ and γ12.
Investigation of the Impact of High Temperatures on the Switching Kinetics of Redox‐Based Resistive Switching Cells using a High‐Speed Nanoheater
Authors: von Witzleben Moritz , Fleck Karsten , Funck Carsten , Baumkötter Brigitte , Zuric Milena , Idt Alexander , Breuer Thomas , Waser Rainer , Böttger Ulrich , Menzel Stephan 
Published: November 2017

AbstractIonic transport greatly influences the switching kinetics of filamentary resistive switching memories and depends strongly on temperature and electric fields. To separate the impact of both parameters on the switching kinetics and to further deepen the understanding of the influence of local Joule heating, a nanometer‐sized heating structure is employed. It consists of a 100 nm wide Pt electrode which, due to Joule heating, serves as heating source upon an electrical stimulus. These self‐heating properties are underlined by a 3D finite elements simulation model, which confirms a temperature increase of almost 500 K. Experimental electrical pulse measurements indicate that for this temperature a steady state is achieved in less than 100 ns. By employing this heating structure, kinetic measurements of a Pt/Ta2O5/Ta cell are performed at different temperatures and reveal that significantly decreased SET times are obtained with increasing temperature. This effect is accompanied by an increasing slope of the current prior to the SET event. The experimental results are further confirmed by predictions of an analytical model based on ionic conduction.
Pursuing an Ethical, Socially Just Classroom: Searching for Community Psychology Pedagogy
Authors: Lichty Lauren F. , Palamaro‐Munsell Eylin 
Published: November 2017

AbstractDiscussions of community psychology (CP) ethics often examine how we might best uphold CP values in community‐based practice. However, for many community psychologists in faculty positions, our main domain of practice is the undergraduate classroom. Teaching is essential to the growth and sustainability of our field as prospective students tend to discover CP during their undergraduate studies. University‐based work is also a key site of CP practice. Universities are contested spaces where interlocking forms of oppression manifest in many ways, including teaching (e.g., what is taught, how, by whom, to whom). CP values compel us to treat our classrooms as more than just information transmission spaces; just as there is no value‐neutral research, there is no value‐neutral course content or classroom practice. This first‐person narrative explores ethical issues that arise when we put CP values, specifically social justice, respect for diversity, participation, and wellness, in conversation with pedagogical best practices and course content in higher education. It presents interrelated ethical dilemmas and the authors’ conflicted responses. We conclude with a four‐part call to the field for dedicated scholarly spaces and supports focused on the development and study of undergraduate CP pedagogy.
A Compact Optical Switch via Plasmonics of Subwavelength Circular‐Sharp Hole Arrays in Metal Films
Authors: Sun Taiming , Deng Zhixiang , Sheng Jiabing , Chen Zhiyong , Zhu Weihua , Guo Wei , Wang Xinlin 
Published: November 2017

AbstractWe studied numerically the enhanced optical transmission (EOT) through periodic subwavelength circular‐sharp hole arrays in metallic films with different edge sharp distribution features of unit structures. Detailed studies indicate that the unit structure edge sharp distribution features strongly influence the surface plasmons (SPs). These results demonstrate that the number of edge sharp activated the localized surface plamons (LSP) resonance on the unit structure is changed by rotating the polarization of the incident light, leading to change the infrared transmittance of the array. Moreover, a compact plasmonic switch via periodic circular‐sharp hole arrays based on the dependence of SPs on unit structural edge sharp distributions is proposed. The finding provides a new idea for designing plasmonics devices, and expands the application range of metal micro‐nano structure in the field of optical communications and information processing.
Ty1‐fused protein‐body formation for spatial organization of metabolic pathways in Saccharomyces cerevisiae
Authors: Han Jong Yun , Song Jae Myeong , Seo Sung Hwa , Wang Chonglong , Lee Seung‐Goo , Lee Hongweon , Kim Seon‐Won , Choi Eui‐Sung 
Published: November 2017

AbstractMetabolite production through a multistep metabolic pathway can often be increased by efficient substrate channeling created by spatial sequestration of the metabolic reactions. Here, Tya, a structural component in the Ty1 retrotransposon element that forms virus‐like particles (VLPs) in Saccharomyces cerevisiae, was used to spatially organize enzymes involved in a metabolic pathway into a multi‐enzyme protein body in yeast. As a proof of principle, Tya fusion to three key enzymes involved in biosynthesis of the isoprenoids farnesene and farnesol was tested to assess its potential to improve productivity. The Tya‐fusion protein resulted in three and fourfold increases in farnesene and farnesol production, respectively, as compared with that observed in a non‐fused control. Specifically, two‐phase partitioning fed‐batch fermentations of S. cerevisiae ATCC200589 overexpressing Tya‐fused enzymes (tHmg1, IspA, and α‐farnesene synthase) yielded 930 ± 40 mg/L of farnesene after 7 days. Additionally, we observed that the Tya‐fusion proteins tended to partition into particulate fractions upon 100,000g ultracentrifugation, suggesting the formation of large aggregates of protein bodies, with their particulate structure also observed by transmission electron microscopy. The dramatic increase in the biosynthetic productivity of metabolites via use of a Tya‐fusion protein suggested that this approach might be useful for the creation of multi‐enzyme complexes to improve metabolic engineering in yeast.
Population-based incidence rate of inpatient and outpatient surgical procedures in a high-income country
Authors: Omling E , Jarnheimer A , Rose J , Björk J , Meara J G , Hagander L 
Published: November 2017

Abstract

Background
The WHO and the World Bank ask countries to report the national volume of surgery. This report describes these data for Sweden, a high-income country.

Methods
In an 8-year population-based observational cohort study, all inpatient and outpatient care in the public and private sectors was detected in the Swedish National Patient Register and screened for the occurrence of surgery. The entire Swedish population was eligible for inclusion. All patients attending healthcare for any disease were included. Incidence rates of surgery and likelihood of surgery were calculated, with trends over time, and correlation with sex, age and disease category.

Results
Almost one in three hospitalizations involved a surgical procedure (30·6 per cent). The incidence rate of surgery exceeded 17 480 operations per 100 000 person-years, and at least 58·5 per cent of all surgery was performed in an outpatient setting (range 58·5 to 71·6 per cent). Incidence rates of surgery increased every year by 5·2 (95 per cent c.i. 4·2 to 6·1) per cent (P &lt; 0·001), predominantly owing to more outpatient surgery. Women had a 9·8 (95 per cent c.i. 5·6 to 14·0) per cent higher adjusted incidence rate of surgery than men (P &lt; 0·001), mainly explained by more surgery during their fertile years. Incidence rates peaked in the elderly for both women and men, and varied between disease categories.

Conclusion
Population requirements for surgery are greater than previously reported, and more than half of all surgery is performed in outpatient settings. Distributions of age, sex and disease influence estimates of population surgical demand, and should be accounted for in future global and national projections of surgical public health needs.
Production of Hydroxynitrile Lyase from Davallia tyermannii (DtHNL) in Komagataella phaffii and Its Immobilization as a CLEA to Generate a Robust Biocatalyst
Authors: Lanfranchi Elisa , Grill Birgit , Raghoebar Zainab , Van Pelt Sander , Sheldon Roger A. , Steiner Kerstin , Glieder Anton , Winkler Margit 
Published: November 2017

AbstractHydroxynitrile lyase from the white rabbit's foot fern Davallia tyermannii (DtHNL) catalyzes the enantioselective synthesis of α‐cyanohydrins, which are key building blocks for pharmaceutical and agrochemical industries. An efficient and competitive process necessitates the availability and robustness of the biocatalyst. Herein, the recombinant production of DtHNL1 in Komagataella phaffii, yielding approximately 900 000 U L−1, is described. DtHNL1 constitutes approximately 80 % of the total protein content. The crude enzyme was immobilized. Crosslinked enzyme aggregates (CLEAs) resulted in significant enhancement of the biocatalyst stability under acidic conditions (activity retained after 168 h at pH 2.4). The DtHNL1–CLEA was employed for (R)‐mandelonitrile synthesis (99 % conversion, 98 % enantiomeric excess) in a biphasic system, and evaluated for the synthesis of (R)‐hydroxypivaldehyde cyanohydrin under reaction conditions that immediately inactivated non‐immobilized DtHNL1. The results show the DtHNL1–CLEA to be a stable biocatalyst for the synthesis of enantiomerically pure cyanohydrins under acidic conditions.
Visceral leishmaniasis triggering an adult‐onset Still's disease: a unique case
Authors: Spoto Silvia , Costantino Sebastiano , Valeriani Emanuele , Fogolari Marta , Cella Eleonora , Dicuonzo Giordano , Ciccozzi Massimo , Angeletti Silvia 
Published: November 2017

Key Clinical MessageAdult‐onset Still's disease (AOSD) due to visceral leishmaniasis (VL) has not been previously reported. This case report analyzes a single episode of AOSD probably due to a visceral leishmaniasis successfully treated with pentamidine isethionate and prednisone.
Tumor lysis syndrome with massive hyperphosphatemia and hyperuricemia
Authors: Koratala Abhilash 
Published: November 2017

Key Clinical MessageTumor lysis syndrome (TLS) occurs when tumor cells release their contents into the bloodstream, typically in response to chemotherapy, leading to the characteristic findings of hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and acute kidney injury. Twinkle artifacts on renal ultrasound may indicate calcium phosphate deposits in such patients.
Spontaneous tumor lysis syndrome in colon cancer: a case report and literature review
Authors: Sommerhalder David , Takalkar Amol M. , Shackelford Rodney , Peddi Prakash 
Published: November 2017

Key Clinical MessageAlthough tumor lysis syndrome is well described, it is rarely seen or suspected in solid malignancies. Early recognition of this entity is paramount in reducing morbidity and mortality. Treating physicians should be aware of this possibility in solid tumor patients with either bulky disease or extensive liver involvement.
Electrochemical Evaluation of Titanocenes in Ionic Liquids with Non‐coordinating and Coordinating Anions and Application for NH3 Synthesis
Authors: Katayama Akira , Inomata Tomohiko , Ozawa Tomohiro , Masuda Hideki 
Published: November 2017

AbstractThe front cover artwork is provided by Akira Katayama, Nagoya Institute of Technology (Japan). The Cover Picture shows the detection of [(Cp2TiCl)2] and generation of NH3. The background is a firework, whose powder explosive comes from N atom‐containing chemicals that are made from NH3. Read the full text of the Article at 10.1002/celc.201700557.
Stereoselective Nanozyme Based on Ceria Nanoparticles Engineered with Amino Acids
Authors: Sun Yuhuan , Zhao Chuanqi , Gao Nan , Ren Jinsong , Qu Xiaogang 
Published: November 2017

AbstractStereoselectivity towards substrates is one of the most important characteristics of enzymes. Amino acids, as cofactors of many enzymes, play important roles in stereochemistry. Herein, chiral nanozymes were constructed by grafting a series of d‐ or l‐amino acids onto the surfaces of ceria (cerium oxide) nanoparticles. We selected the most commonly used drug for combating Parkinson's disease, that is, 3,4‐dihydroxyphenylalanine (DOPA) enantiomers, as examples for chiral catalysis. Through detailed kinetic studies of cerium oxide nanoparticles (CeNPs) modified with different eight amino acids, we found that phenylalanine‐modified CeNP was optimal for the DOPA oxidation reaction and showed excellent stereoselectivity towards its enantiomers. l‐Phenylalanine‐modified CeNPs showed higher catalytic ability for oxidation of d‐DOPA, while d‐phenylalanine‐modified CeNPs were more effective towards l‐DOPA. Taken together, the results indicated that stereoselective nanozyme can be constructed by grafting nanoparticles with chiral molecules. This work may inspire better design of chiral nanozymes.
Three‐dimensional simulations of non‐isothermal flow for gas penetration in complex cavity during gas assisted injection moulding process
Authors: Li Qiang , Niu Haifeng 
Published: November 2017

AbstractIn this paper an R‐function is employed to construct the shape level set (LS) function for representing the complex mould cavity in a gas‐assisted injection moulding (GAIM) process. With the shape LS function, the continuity, momentum, and energy equations can be extended for solving the gas‐liquid two‐phase flows using the finite volume and immersed boundary methods. Firstly, an improved simple coupled level set and volume of fluid (S‐CLSVOF) method is proposed to track the moving interfaces of gas‐liquid interface and polymer melt front. Then the benchmark problems of the two‐ and three‐dimensional deformation tests are carried out to verify the ability of the improved S‐CLSVOF method. At last, the gas penetration processes are simulated in two different complex mould cavities. The numerical results show that the improved S‐CLSVOF method has higher accuracy than the S‐CLSVOF method, and the coupled numerical framework can successfully depict the asymmetry phenomenon of gas flow, racetracking, and fountain phenomena, which has great significance in determining processing conditions and designing mould cavities.
Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation
Authors: Brogi Simone , Maramai Samuele , Brindisi Margherita , Chemi Giulia , Porcari Valentina , Corallo Claudio , Gennari Luigi , Novellino Ettore , Ramunno Anna , Butini Stefania , Campiani Giuseppe , Gemma Sandra 
Published: November 2017

AbstractA computational analysis of the X‐ray structure of the low‐density lipoprotein receptor‐related protein 6 (LRP6) with the Dickkopf‐1 (DKK1) C‐terminal fragment has allowed us to rationally design a small set of decapeptides. These compounds behave as agonists of the canonical Wnt pathway in the micromolar range when tested on a dual luciferase Wnt functional assay in glioblastoma cells. Two of the oligopeptides showed a lack of cytotoxicity in human primary osteoblasts isolated from sponge bone tissue (femoral heads or knees of elderly patients). According to the mechanism of action, the studies revealed a dose‐ and time‐dependent increase in the viability of human osteoblasts. These results may indicate a potential therapeutic application of this class of compounds in the treatment of bone diseases related to aging, such as osteoporosis.
Single Crystals of KRE(MoO4)2, (RE‐ Ce, Pr) Obtained from Fluorides: Scheelite‐Related Structure and Luminescence
Authors: Terebilenko Kateryna V. , Bychkov Konstantin L. , Klymyshyna Kateryna E. , Baumer Vyacheslav N. , Slobodyanik Mykola S. , Khomenko Elena V. , Dotsenko Volodymir P. 
Published: November 2017

AbstractSingle crystals of double molybdates KRE(MoO4)2 (RE = Ce and Pr) have been prepared from high‐temperature melts by a facile and effective fluoride‐assisted method, and investigated by XRD, FTIR and photoluminescence (PL) spectroscopy. The results showed that the molar ratio of K/Mo in the molten solution play an important role in controlling content of the crystalline products. The crystallization fields of KCe(MoO4)2 has been found avoiding oxides admixtures. Both tetragonal scheelite‐related crystal structures have been established by means of single crystal X‐Ray diffraction. Structural motif of KPr(MoO4)2 has been established for the first time, while KCe(MoO4)2 has been reinvestigated and its crystal structure data have been refined. The excitation and emission spectra of KPr(MoO4)2 have been discussed in a light of energy transfer from a molybdate host.
The 3 D Structure of Twisted Benzo[ghi]perylene‐Triimide Dimer as a Non‐Fullerene Acceptor for Inverted Perovskite Solar Cells
Authors: Karuppuswamy Priyadharsini , Chen Hung‐Cheng , Wang Pen‐Cheng , Hsu Chao‐Ping , Wong Ken‐Tsung , Chu Chih‐Wei 
Published: November 2017

AbstractHere, we introduced benzo[ghi]perylenetriimide (BPTI) derivatives including monomer and twisted dimer (t‐BPTI) as an alternative electron‐transport layer (ETL) material to replace the commonly used PC61BM in inverted planar heterojunction perovskite solar cells (PSCs). Moreover, the double ETL was applied in our PSCs with structure of glass/ITO/PEDOT:PSS/perovskite/BPTI/C60 or PDI‐C4/BCP/Al. The use of a double ETL structure can effectively eliminate the leakage current. The devices with the t‐BPTI/C60 double ETL yield an average power conversion efficiency of 10.73 % and a maximum efficiency of 11.63 %. The device based on the complete non‐fullerene electron acceptors of t‐BPTI/PDI‐C4 as double ETL achieved maximum efficiency of 10.0 %. Moreover, it was found that the utilization of alloy t‐BPTI+BPTI as ETL can effectively reduce the hysteresis effect of PSCs. The results suggest that BPTI‐based electron‐transport materials are potential alternatives for widely used fullerene acceptors in PSCs.
Artificial Photosynthesis: Beyond Mimicking Nature
Authors: Dau Holger , Fujita Etsuko , Sun Licheng 
Published: November 2017

AbstractIn this Editorial, Guest Editors Holger Dau, Etsuko Fujita, and Licheng Sun introduce the Special Issue of ChemSusChem on “Artificial Photosynthesis for Sustainable Fuels”. They discuss the need for non‐fossil based fuels, introduce both biological and artificial photosynthesis, and outline various important concepts in artificial photosynthesis, including molecular and solid‐state catalysts for water oxidation and hydrogen evolution, catalytic CO2 reduction, and photoelectrochemical systems.