bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Un)Healthy Neuroticism and Eating Behaviors: A Study of the Nathan Kline Institute for Psychiatric Research - Rockland Sample
Authors: Arend Isabel , Yuen Kenneth 
Published: September 2024

Abstract

Trait neuroticism is associated with maladaptive behaviors and mortality risk. However, high levels of both neuroticism and conscientiousness (i.e., healthy neuroticism) are associated with various positive health behaviors. Eating behavior is a modifiable risk factor for obesity and metabolic diseases. This study investigates the cross-sectional and longitudinal associations between healthy neuroticism and eating behaviors. Data from the Nathan Kline Institute for Psychiatric Research - Rockland Sample included 712 adults with complete assessments of personality, eating behaviors, and clinical metabolic markers. Linear and mixed linear regression models examined cross-sectional and longitudinal associations of eating behaviors and personality, adjusting for socio-demographics (age, sex, education), sleep quality, body mass index (BMI), and metabolic markers. Healthy neuroticism predicted disinhibition and hunger dimensions of eating behavior cross-sectionally, a result that withstood the inclusion of disease burden and clinical metabolic markers. Longitudinally, healthy neuroticism didn't predict changes in eating behavior. Greater conscientiousness scores were associated with increase in restraint, and greater hunger scores with increase neuroticism over time. These findings provide the first evidence that neuroticism is associated with less maladaptive eating behavior tendencies when modulated by conscientiousness. The implications of these associations for potential bidirectional relationships between eating behavior, metabolic health, and personality are discussed.
Trajectory of mean platelet volume changes after aneurysmal subarachnoid hemorrhage in patients with or without delayed cerebral ischemia.
Authors: Chardon Nicolas , Nourredine Mikail , Ledochowski Stanislas , Kurland Noémie Timestit , Dailler Frédéric , Ritzenthaler Thomas , Nougier Christophe , Balanca Baptiste 
Published: September 2024

Abstract

Background
The morbidity of aneurysmal subarachnoid hemorrhage (aSAH) remains high, particularly because of secondary cerebral lesions that significantly aggravate the primary lesions. The main type of secondary lesions is delayed cerebral ischemia (DCI), in which platelets (PLT) appear to play a key role. Mean platelet volume (MPV) is an indirect marker of platelet activation. We aimed to determine the individual trajectories of MPV over time in patients with and without DCI during the course of aSAH.
Methods
This is a single-center, retrospective, longitudinal analysis of individual trajectories of MPV over time, in a cohort of aSAH patients included in the Prospective, Observational Registry of Patient with Subarachnoid Hemorrhage in Neurocritical Care Unit (ProReSHA). A mixed-effects linear regression model was used to compare the trajectories of MPV and MPV/PLT ratio between patients who developed a DCI and those who did not.
Results
A total of 3634 MPV values were collected in 587 patients. The analysis of MPV as a function of DCI occurrence showed a significant difference in the trajectory over time between patients with DCI and those without, with an estimate of 0.02 (95%CI 0.01, 0.04, p = 0.009). The analysis of the MPV/PLT ratio as a function of DCI occurrence and other covariates showed a significant difference in trajectory over time only for patients with a modified Fisher score less than 3, with an estimate of -0.59 (95%CI: -0.94, -0.23, p = 0.001).
Conclusion
The individual trajectories of MPV over time differ between patients with DCI and those without. However, MPV values vary greatly over time and between patients. Thus it does not appear as a reliable biomarker for stratifying patients based on their specific risk of developing DCI.
Trial registration
ClinicalTrials.gov identifier: (NCT02890004), registered in August 2016.
Definition of a Measurement Technique for Hexapod Circular Smart Fixators' Perioperative Assembly Parameters and Investigation of Alignment and Correlation with Postoperative Measurements: A Retrospective Cohort Study
Authors: Kanar Muharrem , Sülek Yusuf , Seymenoğlu Tolga Hayrettin , Armağan Raffi 
Published: September 2024

Abstract

Background: With the assistance of smart fixator technologies, the correction of complex deformities has been facilitated; however, the accurate integration of specialized radiographs and measurements into the system remains the greatest disadvantage, necessitating specialized imaging and an experienced team. When inexperienced technicians and doctors perform these specialized postoperative radiographs, excessive exposure of the patient and team to radioactive rays exacerbates inadequacies in measurements and delays the correction of residual deformities due to angular and translational adjustments. In this study, we compared postoperative measurements with those taken perioperatively via fluoroscopy, hypothesizing that it reduces the exposure of the patient and team to radioactive rays, allows for more accurate and timely correction of deformities and assembly parameters, and reduces time and costs.
Methods: Between 2013 and 2022, 84 patients with bone deformities were retrospectively reviewed. All patients had bone deformities and were treated with computer-assisted circular external fixator systems (Ca-CEF). Assembly parameter measurements began to be corrected via artificial neural network software via perioperative fluoroscopy in 37 patients and postoperative radiography in 47 patients. The surgical duration for all patients, perioperative measurement values, and number of radiographs taken on postoperative day 1, week, and month until deformity correction were recorded.
Results: The duration until deformity correction was shorter in patients who underwent postoperative measurements (mean 50.24 days) than in those who underwent perioperative measurements (mean 42.31 days), but this difference was not statistically significant (p=0.102). The surgical duration was significantly shorter in patients with postoperative measurements (mean of 130.37 minutes) than in those with perioperative measurements (mean of 155.88 minutes) (p=0.045).
For patients with postoperative measurements, 56.04 postoperative radiographs were taken. In contrast, patients with perioperative measurements had fewer radiographs totaling 28.7. This difference was statistically significant (p<0.01). There was no statistically significant difference in the fluoroscopy dose between patients with postoperative measurements (mean 18.54 mGy) and those with perioperative measurements (mean 22.22 mGy) (p=0.105).
Conclusion: To achieve accurate assembly parameters, minimizing X-ray exposure is crucial but can pose challenges. Our results showed that despite an average increase of 25 minutes in surgical duration, the time taken for deformity correction was shorter. Additionally, we obtained fewer postoperative radiographs, indicating reduced radiation exposure.
Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
Authors: Chu Hong-Yuan , Chen Liqiang , Chehade Hiba Douja 
Published: September 2024

Abstract

Dysfunction of the cerebral cortex is thought to underlie motor and cognitive impairments in Parkinson disease (PD). While cortical function is known to be suppressed by abnormal basal ganglia output following dopaminergic degeneration, it remains to be determined how the deposition of Lewy pathology disrupts cortical circuit integrity and function. Moreover, it is also unknown whether cortical Lewy pathology and midbrain dopaminergic degeneration interact to disrupt cortical function in late-stage. To begin to address these questions, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. Using this model system, we reported that αSyn aggregates accumulate in the motor cortex in a layer- and cell-subtype-specific pattern. Particularly, intratelencephalic neurons (ITNs) showed earlier accumulation and greater extent of αSyn aggregates relative to corticospinal neurons (CSNs). Moreover, we demonstrated that the intrinsic excitability and inputs resistance of αSyn aggregates-bearing ITNs in the secondary motor cortex (M2) are increased, along with a noticeable shrinkage of cell bodies and loss of dendritic spines. Last, neither the intrinsic excitability of CSNs nor their thalamocortical input was altered by a partial striatal dopamine depletion associated with αSyn pathology. Our results documented motor cortical neuronal hyperexcitability associated with αSyn aggregation and provided a novel mechanistic understanding of cortical circuit dysfunction in PD.
Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure
Authors: Bernecker Miriam , Lin Anna , Molenaar Anna , Schriever Sonja Charlotte , Pfluger Paul Thomas 
Published: September 2024

Abstract

Background
Obese subjects undergoing weight loss often fear the Yoyo dieting effect, which involves regaining or even surpassing their initial weight. To date, our understanding of such long-term obesity and weight cycling effects is still limited and often based on only short-term murine weight gain and loss studies. This study aimed to investigate the long-term impacts of weight cycling on glycemic control and metabolic health, focusing on adipose tissue, liver, and hypothalamus.
Methods
Chow-fed mice and mice subjected to prolonged high-fat diet (HFD) consumption for 20 weeks, followed by 24 weeks of dietary interventions to either induce weight gain, weight loss, or weight cycling, were assessed for metabolic perturbations. Feeding efficiency, hepatic steatosis, circulating lipids, leptin levels, and glucose homeostasis were measured.
Results
Weight cycling led to hyperphagia and rapid weight regain, matching the weights of mice continuously on HFD. Despite weight loss, adipose tissue inflammation persisted with elevated pro-inflammatory markers and impaired glucose uptake. HFD- induced dysregulation in hypothalamic expression of orexigenic peptides and synaptic plasticity markers persisted even after weight normalization suggesting long-lasting neural alterations. Weight-cycled mice exhibited higher leptin levels, increased hepatic lipid storage, and dysregulated glucose metabolism compared to those with consistent diets, indicating worsened metabolic effects by Yoyo dieting.
Conclusion
In sum, our study highlights significant metabolic risks associated with weight cycling, particularly following prolonged obesity. Persistent adipose tissue inflammation, perturbed neural peptide and plasticity markers and impaired glucose tolerance emphasize the need for effective and sustainable weight loss strategies to mitigate the adverse outcomes of weight regain and improve long-term metabolic health.
Prognostic impact of postoperative management by an intensive care unit intensivist after colonic perforation
Authors: Tominaga Tetsuro , Nonaka Takashi , Yano Hiroshi , Sato Shuntaro , Ichinomiya Taiga , Sekino Motohiro , Hashimoto Shintaro , Shiraishi Toshio , Noda Keisuke , Ono Rika , Hisanaga Makoto , Ishii Mitsutoshi , Oyama Shosaburo , Ishimaru Kazuhide , Hara Tetsuya , Matsumoto Keitaro 
Published: September 2024

Abstract

Purpose
Postoperative management for colonic perforation is an important prognostic factor, but whether intensivists perform postoperative management varies between institutions.
Methods
We investigated 291 patients with colonic perforation between 2018 and 2022. Patients were divided into those managed by an intensivists (ICU group; n = 40) and those not managed by an intensivists (non-ICU group; n = 251). We examined how management by intensivists affected prognosis using inverse probability weighting, and clarified which patients should consult an intensivists.
Results
The ICU group showed a significantly higher shock index (1.15 vs 0.75, p < 0.01), higher APACHE II score (16.0 vs 10.0, p < 0.001), and more severe comorbidities (Charlson Comorbidity Index 5.0 vs 1.0, p < 0.001) and general peritonitis (85% vs 38%, p < 0.001). Adjusted risk differences were − 24% (-34% to -13%) for 6-month mortality rate. Six-month mortality was improved by ICU intensivist management in patients with general peritonitis (risk difference − 23.28; 95% confidence interval − 35 to -11); APACHE II score ≥20 (-0.79; -1.06 to -0.52); lactate ≥1.6 (-0.38; -0.57 to -0.29); shock index ≥1.0 (-40.01; -54.87 to -25.16); and catecholamine index ≥10 (-41.16; -58.13 to -24.19).
Conclusions
Intensivists were involved in treating patients in poor general condition, but prognosis was extremely good. Appropriate case consultation with intensivists is important.
Screening and risk analysis of atrial fibrillation after radiotherapy for breast cancer: Rationale and design for the Watch Your HeaRT cohort study (WATCH)
Authors: Saint-Lary Laura , Pinel Baptiste , Panh Loïc , Jimenez Gaëlle , Geffrelot Julien , Kirova Youlia , Camilleri Jérémy , Broggio David , Bernier Marie-Odile , Mandin Corinne , Levy Christelle , Boveda Serge , Thariat Juliette , Jacob Sophie 
Published: September 2024

Abstract

Background
Post-radiotherapy atrial fibrillation (AF) in breast cancer (BC) patients is a relatively new and understudied topic. AF can increase the risk of stroke and other serious cardiovascular complications, compromising patients' quality of life and survival. Detection of AF, both asymptomatic and symptomatic forms, is therefore essential for optimal management. The objective of the WATCH study is to assess the incidence of AF (symptomatic or asymptomatic) occurring throughout a 5-years follow-up after RT and to investigate whether cardiac radiation exposure is associated with the occurrence of such events.
Methods
WATCH is a cohort study that will include 200 patients over 65 years old, treated with radiotherapy for BC five years before inclusion, without history of AF. Cross-sectional screening for AF at the time of the scheduled five-year post-radiotherapy visit is conducted by recording data from a Withings ScanWatch smartwatch for one month, confirmed by an ECG, and validated by a physician. In addition, a transthoracic echocardiography is performed, providing comprehensive assessment of cardiac structures, and allowing to investigate underlying etiology and assess the risk of complications. Patient's medical record provides retrospective information on the timing and risk factors for the occurrence of AF and other arrhythmias and cardiac diseases during the 5 years following RT. The development of deep learning algorithms for auto-segmentation analysis of potentially critical sub-structures for the occurrence of AF, including cardiac chambers, sinoatrial node, atrioventricular node, coronary arteries, pulmonary veins, will produce dosimetry linked to previous radiotherapy treatment for all contoured structures. The inclusions started in October 2023 and will continue until mid-2026 to include 200 patients. The results are expected by the end of 2026.
Discussion
This study will contribute to generating new knowledge on AF after radiotherapy for BC, and help considering AF screening into routine clinical practice in these patients. Identifying the dose-risk associations would improve RT delivery protocols to limit the occurrence of these arrhythmias and, if necessary, initiate appropriate treatment.
Trial registration
ClinicalTrials.gov:NCT06073509. Registration date: 10/09/2023
Present-day crustal uplift and dynamic process of the Tibetan Plateau from multiple geodetic observations
Authors: Pan Yuanjin , Li Zhenhong , Jiao Jiashuang , He Meilin , Li Jiangtao , Xiao Yixin , Peng Jianbing 
Published: September 2024

Abstract

Vertical land motion (VLM) on the Tibetan Plateau (TP) is influenced by various geophysical factors, including surface fluid mass variations and tectonic deformation. In this study, we investigate the present-day crustal uplift in the TP using geodetic observations, including Global Navigation Satellite System (GNSS) and precise leveling. A hydrological load deformation model is formulated by integrating the Gravity Recovery and Climate Experiment and Follow-On (GRACE/GFO) satellite gravity with a surface hydrological fusion model. Tectonic-induced VLM is calculated after correcting for surface elastic deformation, geocentric motion (-0.1 to -0.2 mm yr-1) and glacial isostatic adjustment (0.3 to 0.4 mm yr− 1). The comprehensive VLM imaging and dynamic tomography reveal significant crustal uplift in the southern and northeastern TP, with uplift rates up to 2 mm yr-1, primarily attributed to plate compression. The northern and southeastern TP exhibit complex vertical tectonic movements, potentially influenced by block extrusion and mid-lower crustal flow.
Dual-Source CT in Predicting and Treating Uric Acid Stones: A Retrospective and Prospective Study
Authors: Li Wang , Xie Hong , Lin Yanduo , Chen Rong , Zheng Kun , Yang Luyi , Yang Ranxing 
Published: September 2024

Abstract

Purpose
To evaluate the clinical application of dual-source CT in analyzing and treating urinary tract stone components.
Methods
A retrospective study of 204 patients with upper urinary tract stones who underwent preoperative dual-source CT and postoperative infrared spectroscopic stone analysis. Preoperative CT parameters were compared to assess diagnostic efficacy. A prospective study selected 60 patients predicted to have uric acid stones by dual-source stone energy spectrum CT, divided into experimental and control groups. The control group received diet and exercise therapy, while the experimental group received additional sodium potassium hydroxy citrate to dissolve the stones.
Results
Retrospective study: 204 patients (159 males, 45 females, mean age 50.7 ± 14.3 years). Stone length diameter (13.4 ± 5.1) mm. Significant differences in CT values for different stone types, with uric acid stones having lower CT values. ROC curves indicated high accuracy for dual-source CT, particularly at 100 kV. Prospective study: 60 patients (32 males, 28 females, mean age 61.2 ± 11.8 years), 38 renal stones, 22 ureteral stones. Experimental group showed higher complete dissolution rate (80% vs. 20%), lower non-response rate (3.3% vs. 33.3%), and lower surgical treatment rate (3.3% vs. 30%) at three-month follow-up. Urine pH improved in the trial group, with no significant change in uric acid levels. Incidence of renal colic was slightly lower in the trial group. Dual-source CT accuracy for predicting uric acid stones was 96.7%.
Conclusion
Dual-source CT accurately predicts uric acid stones to guide treatment choices, improving patient outcomes and reducing surgery need.
The Efficacy of Low-Intensity Shock Wave Therapy based on the Stratification of Erectile Dysfunction Patients: A Long-term Follow-up
Authors: Elshorbagy Galal , Elsayed Ahmed Salah , Elghoneimy Mohamed , Abdelrassoul Mohamed Abdo , Elkousy Mohamed Magdy , Ragab Mohamed Wael , Gharably Mohamed Aboul Fotouh El 
Published: September 2024

Abstract

Background
Low intensity extracorporeal shockwave therapy (LIESWT) has a considerable positive influence on erectile function (EF) among individuals diagnosed with vasculogenic erectile dysfunction (ED). This research aimed to investigate the impact of LI-ESWT on several subcategories of ED and to determine the duration of the enhancement in erectile function by a comprehensive long-term follow-up.
Methods
This was a retrospectively collecting data from prospectively kept database. Individuals diagnosed with vasculogenic ED received 6–12 sessions of LI-ESWT with 5000 impulses at a dosage of 0.01 j/mm2. The therapy was administered employing the electromagnetic Dornier Aries® 1 machine. Each patient underwent at least 6 sessions of LI-ESWT. Subsequently, the participants had clinical assessment utilizing the International Index of Erectile Function (IIEF-EF) and the Erection Hardness Scores (EHS) domain score at three months after LI-ESWT, followed by assessments every 6 months. Additionally, the penile blood flow dynamics were assessed three months after LI-ESWT and during the final follow-up examination.
Results
A total of 42 individuals had been determined, with a mean age of 50 ± 12 years. The mean duration of ED was 31 ± 35 months, and the mean period of follow-up was 10 ± 6 months. The initial IIEF-EF score was 16 ± 6 and increased to 22 ± 6 after 3 months, and then decreased to 21 ± 6 at the final follow-up (p < 0.01). A minimal clinically significant variation was observed in 69% of participants at 3 months and in 60% of the entire study population at the final follow-up. The factors of risk that were shown to be related with a greater likelihood of MICD at 3 months had been age (p = 0.01), uncontrolled diabetes mellitus (DM) ratio (p = 0.04), hypertension (p = 0.24), cardiovascular disease (p = 0.8), smoking (p = 0.63), and ex smoking (p = 0.3).
Conclusions
Li-ESWT shows promising long-term effectiveness in treating various degrees of ED, as demonstrated by the enhancement in penile blood flow observed during the final follow-up. This effect is particularly notable in individuals with well-managed DM and older age.
Research and application of bearing characteristics of combined support roof cutting in gob-side entry retaining
Authors: Wu Xiaoyu , Wu Xiaowei , Zhang Nan 
Published: September 2024

Abstract

In fully-mechanized longwall mining, gob-side entry retaining is a no-coal-pillar mining technology, which can increase the recovery of coal pillar resources, reduce the amount and cost of roadway excavation. However, the surrounding rock of the retained roadway produces large deformation due to the turning and sinking movement of the roof, and the stress transfer from the overlying rock layer can be effectively reduced by cutting off the immediate roof and the main roof.This paper introduces the formation and control mechanism of cutting roof along the gob-side entry retaining, and mainly investigates the synergistic bearing characteristics of the roof-cutting support and gangue roadside support.The results of engineering practice show that: cutting off of thick roof along the gob-side entry retaining is feasible, fully meet the site production requirements. In the process of cutting roof, the gangue collapses and swells to form gangue roadside support. The gangue roadside support and the roof-cutting support beside the roadway carries the roof pressure, forming the cooperative bearing structure. In this way, the damage rate of the roof-cutting support is low, the deformation of the roadway is small, and the control effect is remarkable.