bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do General Managerial Skills Spur Innovation?
Authors: Custódio Cláudia , Ferreira Miguel A. , Matos Pedro 
Published: September 2017

We show that firms with chief executive officers (CEOs) who gain general managerial skills over their lifetime of work experience produce more patents. We address the potential endogenous CEO–firm matching bias using firm–CEO fixed effects and variation in the enforceability of noncompete agreements across states and over time during the CEO’s career. Our findings suggest that generalist CEOs spur innovation because they acquire knowledge beyond the firm’s current technological domain, and they have skills that can be applied elsewhere should innovation projects fail. We conclude that an efficient labor market for executives can promote innovation by providing a mechanism of tolerance for failure. The Internet appendix is available at https://doi.org/10.1287/mnsc.2017.2828 . This paper was accepted by Gustavo Manso, finance.
The Bull of Wall Street: Experimental Analysis of Testosterone and Asset Trading
Authors: Nadler Amos , Jiao Peiran , Johnson Cameron J. , Alexander Veronika , Zak Paul J. 
Published: September 2017

Growing evidence shows that biological factors affect individual financial decisions that could be reflected in financial markets. Testosterone, a chemical messenger especially influential in male physiology, has been shown to affect economic decision making and is taken as a performance enhancer among some financial professionals. This is the first experimental study to test how testosterone causally affects trading and prices. We exogenously elevated testosterone in male traders and tested testosterone’s effect both on their trading behavior in experimental asset markets and on the size and duration of asset price bubbles. Using both aggregated and individual trading data, we find that testosterone administration generated larger and longer-lasting bubbles by causing high bids and the slow incorporation of the asset’s fundamental value.The e-companion is available at https://doi.org/10.1287/mnsc.2017.2836 .This paper was accepted by Uri Gneezy, behavioral economics.
Dual Coproduct Technologies: Implications for Process Development and Adoption
Authors: Chen Ying-Ju , Tomlin Brian , Wang Yimin 
Published: September 2017

Many industries operate technologies in which multiple outputs (coproducts) are jointly produced. In some settings (“vertical”) the coproducts differ along a performance dimension and are substitutable. In other settings (“horizontal”) the coproducts differ in their applications and are not substitutable. In both cases, three important attributes of a coproduct technology are its processing cost, overall yield, and coproduct split, i.e., the proportion of each output produced. For both vertical and horizontal settings with deterministic market sizes, we characterize the optimal pricing and production decisions of a monopoly firm with two technologies. We establish the necessary and sufficient conditions for dual activation (i.e., using both technologies) to be optimal. Dual activation is driven by differences in marginal costs across the two technologies. There is an additional motive for dual activation in the horizontal setting: the desire to generate a product mix that better resembles the market mix. Building on the optimal production analysis, we characterize the optimal adoption-and-usage strategy of a firm with one incumbent technology considering a new technology. We establish the conditions for which a new technology will displace the incumbent or be used with the incumbent, and highlight some important adoption and usage differences between vertical and horizontal settings. Results are extended to the setting with uncertain market size(s). The online appendix is available at https://doi.org/10.1287/msom.2017.0637 .
Supply and Demand Functions in Inventory Models
Authors: Feng Qi , Shanthikumar J. George 
Published: September 2017

The central issue in supply chain management is to match supply with demand, and the heart of a planning model is the modeling of supply and demand functions. To allow for analytical tractability, the existing literature often assumes almost surely linear supply and demand functions, which greatly limits the applicability of the models. The goal of this paper is to provide a unified approach to analyze general random supply and demand functions. By transforming the problem into one defined on a higher dimension, we show that many of the seemingly highly nonlinear supply and demand functions (in the almost sure sense) are linear in the stochastic sense. With this new notion of linearity, called stochastic linearity in midpoint, our ability to analyze supply chain problems is much enhanced. We are able to prove the concavity of the profit function in the transformed supply and demand decisions for a general class of supply and demand functions that include, but are not restricted to, the ones studied in the existing literature. Thus, many of the challenging problems now become tractable. Moreover, we characterize a set of easy-to-verify conditions for stochastic linearity in midpoint. The online appendix is available at https://doi.org/10.1287/opre.2017.1648 .
Optimal Metering Point Configurations for Optimized Profile Descent Based Arrival Operations at Airports
Authors: Solak Senay , Chen Heng 
Published: September 2017

Optimized profile descent (OPD) is an arrival procedure for the Next Generation Air Transportation System, which has been demonstrated to effectively decrease noise, emissions, and fuel costs. Implementation of OPD operations requires effective metering policies because of the increased role of uncertainty in aircraft trajectories during descent. While optimal sequencing and spacing of OPD flights have been studied in the literature, any potential savings resulting from possible changes in metering point configurations have not been addressed. In this paper, we develop models to further increase the value of OPD operations over conventional arrival procedures by optimizing metering point configurations, which include identification of the optimal number and locations of metering points to use during OPD. We derive an algorithmic framework based on implementations of a stochastic dynamic programming model and a nonlinear stochastic integer program to identify best metering point configurations where resulting computational difficulties are addressed through convex approximation and Lagrangian decomposition procedures. We also describe numerical results based on actual traffic information at major U.S. airports, which indicate that the total potential savings in the top 10 major airports could be up to $22 million a year if the proposed policies are implemented. The online appendix is available at https://doi.org/10.1287/trsc.2017.0788 .
ENZIMAS VEGETAIS: EXTRAÇÃO E APLICAÇÕES BIOTECNOLÓGICAS
Authors: Antunes Rafael Souza , Lopes Flavio Marques , Brito Andressa de Oliveira , Garcia Luane Ferreira , Sousa Denes Ferraz de , Gil Eric de Souza 
Published: September 2017

O artigo descreve as metodologias analíticas atuais mais utilizadas na obtenção de enzimas vegetais para aplicações biotecnológicas. São relatados os métodos de isolamento e purificação parcial, que se resumem nas técnicas cromatográficas e eletroforéticas, enfatizando a importância dessas enzimas nas pesquisas em Biotecnologia, com foco nas suas aplicações, características e peculiaridades. No que se refere à aplicabilidade, o artigo traz diversos exemplos na produção de alimentos, na fabricação e produção de biossenssores para determinação de diversos analitos e na biorremediação, que que tem como objetivo a remoção de poluentes do ambiente natural e a sua conversão em produtos menos prejudiciais, utilizando, para isso, as enzimas vegetais. Interesses industriais também são discutidos.
VANTAGENS DA IMPLANTAÇÃO DO PRONTUÁRIO ELETRÔNICO NA SEGURANÇA DO PACIENTE E NA OTIMIZAÇÃO DO TRABALHO DO FARMACÊUTICO HOSPITALAR
Authors: Crippa Valdinara , Colombo Dias Diego Roberto 
Published: September 2017

Com o objetivo de analisar as contribuições do prontuário eletrônico na garantia da segurança do paciente no uso de medicamentos em hospitais, e seu reflexo na otimização do trabalho do farmacêutico hospitalar, foi feita uma revisão sistemática de artigos originais apresentando benefícios referentes à segurança da prescrição e administração de medicamentoscom o uso do prontuário eletrônico em hospitais. Estudos relevantes foram identificados por meio das bases de dados PUBMED, LILACS, MEDLINE e Scielo. Foram retornados 99 artigos, dos quais 10 que melhor atenderamaos critérios estabelecidos, foram selecionados para discussão. A análise apontou o uso do prontuário eletrônico em hospitais como favorável para viabilizar maior apoio à decisão clínica e monitoramento de medicamentos, redução de erros, realização de intervenções atempada e maior agilidade e organização dos processos de trabalho, concluindo que o prontuário eletrônico contribui para a qualidade e eficiência da assistência prestada e otimiza o trabalho dos farmacêuticos e demais profissionais da rede hospitalar.
CONSUMO DE ÁLCOOL ENTRE ESTUDANTES DO CURSO DE NUTRIÇÃO E FATORES ASSOCIADOS
Authors: Damasceno Eurislene Moreira Antunes , Nascimento Eliete Bispo , Leite Iane Francielle Duarte , Barbosa Henrique Andrade , David Nathália Jamille Moreira Nascimento , Rocha Ricardo Lopes , Pinheiro Marcos Luciano Pimenta 
Published: September 2017

O objetivo do estudo foi verificar a prevalência do consumo de álcool entre os estudantes do Curso de Graduação em Nutrição de uma instituição privada da cidade de Montes Claros, MG. É um estudo descritivo realizado entre os meses de agosto e setembro de 2015. Participaram 152 estudantes do curso de Nutrição, maiores de 18 anos (94,7% mulheres e 5,3% homens). Foram utilizados dois questionários autoaplicáveis. A faixa etária predominante foi entre 18 a 24 anos (67%). A maioria dos entrevistados declarou ser abstinente ou fez uso de baixo risco (94,8%). Para uma minoria(5,2%), o uso foi considerado de risco nos últimos 12 meses. sendo que 104 acadêmicos (68,4%) desistiram de assistir as aulas, para ir a bares, festas ou outros eventos, e dois (1,3%) trancaram a matricula, demonstrando um consumo considerado prejudicial, com possíveis consequências negativas. Foi observado um consumo de álcool de baixo risco na grande maioria dos estudantes. Assim, é necessária a adoção de medidas de promoção da saúde no intuito de diminuir ou zerar os índices de uso abusivo do álcool, mesmo em uma pequena minoria, estendendo a pesquisa aos outros cursos da faculdade, a fim melhorar a qualidade de vida e o rendimento escolar dos egressos.
PRESCRIÇÕES DE ANTIBACTERIANOS EM UMA DROGARIA DO MUNICÍPIO DE TANABI, SÃO PAULO, BRASIL
Authors: Maschio de Lima Tiago Aparecido , Silva Tamiris Campos da , Pereira Luis Lênin Vicente , Godoy Moacir Fernandes de 
Published: September 2017

Os antimicrobianos são substâncias que previnem a proliferação ou provocam a morte de fungos ou bactérias, combatendo e prevenindo o avanço de uma infecção. O uso abusivo ou inadequado desses fármacos acarreta o desenvolvimento de cepas de multirresistentes O objetivo desse estudo foi descrever o perfil de consumo de antibióticos em uma drogaria do município de Tanabi, São Paulo, Brasil. Trata-se de um estudo retrospectivo, descritivo, exploratório com abordagem quantitativa. Foram analisadas 128 cópias das prescrições de antibióticos recebidas durante o ano de 2016. 64% das prescrições foram destinadas ao sexo feminino. A média de idade foi 46±25 anos. Os antibióticos mais prescritos foram cefalexina (23%), amoxicilina associada ao clavulanato (22%), ciprofloxacino (17%) e azitromicina (15%). Consequentemente, os grupos farmacológicos mais utilizados foram beta-lactâmicos (55%), fluoroquinolonas (30%) e macrolídeos (15%). Os prescritores mais frequentes foram médicos generalistas (42%,) dentistas (12%), cardiologistas (9%) e urologistas (7%). A maior parte das prescrições foi advinda do sistema privado de saúde (54%). Os prescritores utilizaram o nome comercial em 55% dos antibacterianos prescritos, dos quais 33% foram oriundos do Sistema Único de Saúde. Esta pesquisa contribui na avaliação do uso de medicamentos antibióticos na população. A atuação efetiva do farmacêutico no controle do uso de antibióticos de acordo com a legislação vigente é importantepara prover a população com orientações adequadas sobre o uso racional desses agentes.
USO DE ESPECTROSCOPIA DE ULTRAVIOLETA VISÍVEL (UV-VIS) PARA A DETECÇÃO DE QUERCETINA EM PLANTAS POR MEIO DA FORMAÇÃO DO COMPLEXO QUERCETINA-ALUMÍNIO
Authors: Bernardi Fabiele , Nicolini Keller Paulo , Nicolini Jaqueline 
Published: September 2017

Foram estudadas nove amostras de plantas a partir da reação de complexação que ocorre entre alumínio, proveniente do cloreto de alumínio (AlCl3) e quercetina, presente no material botânico avaliado. A reação é caracterizada pela formação de uma solução amarela, evidenciada espectroscopicamente pelo deslocamento batocrômico da região de360-370 nm para 420-430 nm. Foram investigadas quatro amostras de pétalas: azaleia branca e magenta, lírio amarelo queimado e dente-de-leão; três amostras de folhas: babosa, laranja e lima; e duas amostras de cascas de frutos: laranja e lima. Dentre as amostras analisadas, apenas as pétalas de azaleia (Rhododendron sp.) branca e magenta presentaram concentração de quercetina suficiente para ser detectada e analisada por espectroscopia de UV-Vis pela formação do complexo quercetina-alumínio. A interação entre o alumínio e a quercetina apresenta estequiometria 2:1, com uma constante de ligação de 3,94 ± 0,34 x 103 mol L-1.
Combination treatment with valsartan and amlodipine intensifies evening suppression of Bmal1 clock gene in kidneys of spontaneously hypertensive rats
Authors: Potucek P. , Radik M. , Doka G. , Kralova E. , Krenek P. , Klimas J. 
Published: September 2017

Abstract
Blood pressure (BP) rhythm is exhibited in a circadian pattern regulated by complex system of endogenous factors. Administration of pharmacological treatment at the right time can influence the efficacy of treatment; but while kidneys play significant role in BP regulation, little is known about their role in chronopharmacotherapy. This study aimed to compare differences between morning and evening dosing with valsartan and amlodipine combination in both short-term and long-term settings and to elucidate the role of kidneys in chronopharmacology. Spontaneously hypertensive rats aged between 8 and 10 weeks were daily treated with 10mg/kg of valsartan and 4 mg/kg of amlodipine, either in the morning or in the evening with treatment duration of 1 and 6 weeks. After short-term treatment, only morning treatment group demonstrated significantly better outcomes in terms of BP control when compared to placebo. After long-term treatment, both treatment groups gained superior results in BP control against placebo; however, no significant difference was seen between morning and evening treatment. Interestingly, clock gene expression in kidney has been significantly modulated only in the evening-treated groups, with treatment intensifying the reduced Bmal1 levels, while Per2 expression was less altered. However, no direct relation with the outcomes of the therapy has been observed, suggesting that pharmacotherapy may serve as an independent modulator of peripheral circadian clock in the kidney.
Conservative finite volume element schemes for the complex modified Korteweg–de Vries equation
Authors: Yan Jin-Liang , Zheng Liang-Hong 
Published: September 2017

Abstract
The aim of this paper is to build and validate a class of energy-preserving schemes for simulating a complex modified Korteweg–de Vries equation. The method is based on a combination of a discrete variational derivative method in time and finite volume element approximation in space. The resulting scheme is accurate, robust and energy-preserving. In addition, for comparison, we also develop a momentum-preserving finite volume element scheme and an implicit midpoint finite volume element scheme. Finally, a complete numerical study is developed to investigate the accuracy, conservation properties and long time behaviors of the energy-preserving scheme, in comparison with the momentum-preserving scheme and the implicit midpoint scheme, for the complex modified Korteweg–de Vries equation.
The interval Shapley value of an M/M/1 service system
Authors: Cheng-Guo E , Li Quan-Lin , Li Shiyong 
Published: September 2017

Abstract
Service systems and their cooperation are one of the most important and hot topics in management and information sciences. To design a reasonable allocation mechanism of service systems is the key issue in the cooperation of service systems. In this paper, we systematically introduce the interval Shapley value as cost allocation of cooperative interval games 〈N, V〉 arising from cooperation in a multi-server service system, and provide an explicit expression for the interval Shapley value of cooperative interval games 〈N, V〉. We construct an interval game 〈N, W〉 of a service system which shares the same value for the grand coalition with the original interval game, by using the characteristic function which is dominated by the function of the original interval game. Finally, we prove that the interval game 〈N, W〉 is concave, which means that the interval Shapley value of the interval game 〈N, W〉 is in the interval core of this interval game, and illustrate this conclusion by using numerical examples.
A comparative study on interval arithmetic operations with intuitionistic fuzzy numbers for solving an intuitionistic fuzzy multi–objective linear programming problem
Authors: Vidhya Rajendran , Irene Hepzibah Rajkumar 
Published: September 2017

Abstract
In a real world situation, whenever ambiguity exists in the modeling of intuitionistic fuzzy numbers (IFNs), interval valued intuitionistic fuzzy numbers (IVIFNs) are often used in order to represent a range of IFNs unstable from the most pessimistic evaluation to the most optimistic one. IVIFNs are a construction which helps us to avoid such a prohibitive complexity. This paper is focused on two types of arithmetic operations on interval valued intuitionistic fuzzy numbers (IVIFNs) to solve the interval valued intuitionistic fuzzy multi-objective linear programming problem with pentagonal intuitionistic fuzzy numbers (PIFNs) by assuming different α and β cut values in a comparative manner. The objective functions involved in the problem are ranked by the ratio ranking method and the problem is solved by the preemptive optimization method. An illustrative example with MATLAB outputs is presented in order to clarify the potential approach.
Heuristic algorithms for joint optimization of unicast and anycast traffic in elastic optical network–based large–scale computing systems
Authors: Markowski Marcin 
Published: September 2017

Abstract
In recent years elastic optical networks have been perceived as a prospective choice for future optical networks due to better adjustment and utilization of optical resources than is the case with traditional wavelength division multiplexing networks. In the paper we investigate the elastic architecture as the communication network for distributed data centers. We address the problems of optimization of routing and spectrum assignment for large-scale computing systems based on an elastic optical architecture; particularly, we concentrate on anycast user to data center traffic optimization. We assume that computational resources of data centers are limited. For this offline problems we formulate the integer linear programming model and propose a few heuristics, including a meta-heuristic algorithm based on a tabu search method. We report computational results, presenting the quality of approximate solutions and efficiency of the proposed heuristics, and we also analyze and compare some data center allocation scenarios.
On the existence of a nontrivial equilibrium in relation to the basic reproductive number
Authors: Wijaya Karunia Putra , Sutimin  , Soewono Edy , Götz Thomas 
Published: September 2017

AbstractEquilibrium analysis in autonomous evolutionary models is of central importance for developing long term treatments. This task typically includes checks on the existence and stability of some equilibria. Prior to touching on the stability, one often attempts to determine the existence where the basic reproductive numberℛ0plays a critical role as a threshold parameter. When analyzing a nontrivial equilibrium (e.g., an endemic, boundary, or coexistence equilibrium) whereℛ0is explicit, we usually come across a typical result: ifℛ0>1, then a nontrivial equilibrium exists in the biological sense. However, for more sophisticated models,ℛ0can be too complicated to be revealed in terms of the involving parameters; the task of relating the formulation of a nontrivial equilibrium toℛ0thus becomes intractable. This paper shows how to mitigate such a problem with the aid of functional analysis, adopting the framework of a nonlinear eigenvalue problem. An equilibrium equation is first to be transformed into a canonical equation in a lower dimension, and then the existence is confirmed under several conditions. Three models are tested showing the applicability of this approach.
Evaluation of Early Postoperative Cognitive Dysfunction Incidence and Involved Neurocognitive Functions in Patients with Cardiac and Noncardiac Surgery Under General Anesthesia
Authors: Sircuţa Carmen , Lucza Tunde , Veres Mihaly , Szomoru Ildiko , Azamfirei Leonard 
Published: September 2017

Abstract

Objective: To analyse postoperative cognitive dysfunction’s (POCD) incidence and cognitive areas involved, in patients with cardiac and general surgery.

Material and Methods: Prospective observational study on 130 patients undergoing general or heart surgery on cardiopulmonary bypass, under general anesthesia. Two groups, 65 members each. Group A had a heart surgery and group B a noncardiac surgery. The same type of anesthetic drugs were used. All patients completed the Montreal Cognitive Assesment (MoCA) questionnaire: preoperative, 24 hours after stopping any medicine acting on central nervous system and 7 days postoperative. We compared the MoCA scores obtained on different cognitive domains in this moments for each group of patients, for neurocognitive functions: visuo-spatial executive, naming, attention, verbal fluency, abstraction, recall, orientation, final score. We compared the scores between the two groups at 24 hours and 7 days postoperatively for the same domains.

Results: POCD was found at 24 hours testing in both groups. At 7 days postoperatively POCD was not found in any of the groups. There was no statistically significant difference in total final score between two groups at 24 hours nor at 7 days postoperative testing. There are significant differences between the two groups, with lower score in cardiac group in 5 of 7 fields at 24 hours testing, with the persistence of difference in 2 of 7 fields at 7 days.

Conclusions: Overall POCD was present at 24 hours but was not found at 7 days testing for none of the groups. POCD is present in some neurocognitive domains and this depends on surgery type.
Transthoracic 3D Echocardiographic Imaging of Type A Aortic Dissection – Case Presentation
Authors: Szabó István Adorján , Kocsis Ildikó , Fogarasi Zoltán , Belényi Boglárka , Frigy Attila 
Published: September 2017

Abstract
In type A aortic dissection (AoD) an early and accurate diagnosis is essential to improve survival, by applying urgent surgical repair. 3D transthoracic echocardiography (3D-TTE), an advanced noninvasive imaging technique, could offer a comprehensive evaluation of the ascending aorta and aortic arch in this regard. Both modalities of real-time 3D imaging – live 3D and full-volume aquisition – proved to be useful in evaluating the localization and extent of AoD. Our case illustrates the utility of 3D-TTE in the complex assessment AoD. By providing the proper anatomical dataset, 3D-TTE could facilitate considerably the diagnosis of type A AoD.