bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information and performance optimization: a study of Indian IPOs during 2005-2012
Authors: Chhabra Sheena , Kiran Ravi , Sah A.N. , Sharma Vikas 
Published: October 2017

PurposeThe purpose of this paper is to focus on examining the first day returns of initial public offerings (IPOs) and the role of information on their performance. The study tries to optimize the returns of the new issues during 2005-2012 with risk as a constraint.Design/methodology/approachThe initial returns are measured through the market-adjusted excess return and the risk associated with the new issue is measured through underwriters’ reputation. The returns have been optimized through a mixed integer linear problem using the Maple software.FindingsThe previous studies show that various informational variables affect the listing day returns significantly. The results of the present study indicate that the mean of initial returns for IPOs during 2005-2012 is 18.03 and the mean risk for these issues is 0.46. The findings also suggest that the optimal returns are obtained in the pre-recession era (2005-2008) and the value for the same is 50.02 percent.Originality/valueThe current study contributes in the investment decisions for global investors as every investor wants to maximize his/her returns. The optimal returns with risk as a constraint will help the investors in improving their investment decision as a prudent investor does not aim solely at maximizing the expected return of an investment but is also interested in optimizing with the minimization of risk.
The effect of algorithm teaching on the problem-solving skills of deaf-hard hearing students
Authors: Deveci Topal Arzu , Çoban Budak Esra , Kolburan Geçer Aynur 
Published: October 2017

PurposeThe purpose of this paper is to identify the effects of algorithm teaching on the problem-solving skills of deaf-hard hearing students.Design/methodology/approachIn this research, a pre-test and post-test problem-solving scale was applied to the single group (16 deaf-hard hearing students at a secondary school level) that had received algorithm education. Pre-test and post-test results were compared in order to see whether there was a significant difference among students in terms of their problem-solving attitudes. Students’ levels of performing the applications were examined through observation forms and their opinions about algorithm teaching were received.FindingsAs a result of the research, it was determined that implemented algorithm teaching had a significant effect on improving the problem-solving skills of the students.Originality/valueScratch training can be administered as either a compulsory or an optional course for hearing students as the Scratch programme offers the opportunity of teaching algorithmic reasoning with games, making the courses entertaining and giving students the chance to create their own designs which helps to improve their creative problem-solving skills and their motivation accordingly. Scratch teaching can be beneficial in developing students’ problem-solving behaviours and creativity.
Determinants of personal factors in influencing the buying behavior of consumers in sales promotion: a case of fashion industry
Authors: Rehman Fazal ur , Bin Md Yusoff Rosman , Bin Mohamed Zabri Shafie , Binti Ismail Fadillah 
Published: October 2017

PurposeThis study aims to investigate the influence of personal factors on the buying behavior of consumers with the intentions of sales promotion in the fashion industry. Precisely, it focuses on the marketing techniques and practices in sales promotion activities to influence the buying intentions of consumers in personal ways.Design/methodology/approachBased on a comprehensive literature review of personal factors, sales promotion and buying behavior, this study has applied a positivist approach to collect data in quantitative way through questionnaires-based survey. The study has analyzed the collected data using structural equation modeling through smart partial least square.FindingsPersonal factors and its sub-dimensions such as market maven, stability and open minded have demonstrated a positive relationship in the conceptual construct. In the same manner, sales promotion and its sub-dimensions like social factors and physical layout have also positive effects.Research limitations/implicationsThis study is only limited to the fashion industry of Pakistan and future research may be conducted in other services and manufacturing industries. Future research may assess the role of moderating variables like gender.Practical implicationsThis study clarifies the influence of personal characteristics on consumers buying behavior in sales promotion activities in the fashion industry to achieve business objectives.Originality/valueBy integrating personal factors and sales promotion literature, the main contribution of this paper is the analysis of personal characteristics and promotional practices in the fashion industry of Pakistan, during Eid-ul-Fitter holidays to enhance the consumers buying behavior. Precisely, this study has assessed the effect some unique characteristics of consumers like market maven, stable, open minded and agreeable on their buying behavior in sales promotion activities. This study has apprised marketing professionals to apply the conception of personal characteristics in sales promotion activities to boost up the buying behavior of consumers in enthusiastic way.
Binge watching and college students: motivations and outcomes
Authors: Panda Swati , Pandey Satyendra C. 
Published: October 2017

Purpose
The purpose of the paper is to explore various motivations that influence college students to spend more time binge watching and the subsequent gratifications. Video streaming websites such as Netflix and Amazon Video have changed the viewing habits of consumers. Viewers have more control and can enjoy on-demand content as per their convenience. This has resulted in viewers watching multiple episodes of television shows in a compressed time frame – a phenomenon termed as binge watching. College students engage in binge watching because of the various gratifications that it promises. This paper investigates the various triggers and consequences of binge watching.

Design/methodology/approach
Data were collected through a mixed method approach. The first stage involved qualitative interviews and focused group discussions with college students to understand the phenomenon of binge watching. The second stage involved administering a questionnaire to address our research question.

Findings
Findings indicate that social interaction, escape from reality, easy accessibility to TV content and advertising motivate college students to spend more time binge watching. If students are negatively gratified after binge watching, then they intend to spend more time doing it.

Originality/value
The findings have important implications on the overall wellbeing of college students and strategic implications for video streaming companies.
Co-designing with young consumers – reflections, challenges and benefits
Authors: Durl James , Trischler Jakob , Dietrich Timo 
Published: October 2017

Purpose
This paper aims to explore co-design as a method for actively involving young consumers in the design of an alcohol education program that utilizes an interactive Virtual Reality (VR) component.

Design/methodology/approach
Dietrich et al. (2017) six-step framework was applied to a co-design project involving four groups of 14- to 16-year-old Australian high school students. Data collection included observations by three facilitators, written feedback from members of each group and video presentations of the generated ideas. The data analysis focused on investigating the applicability of the six-step framework to young consumers and evaluating the quality and practicality of the generated ideas.

Findings
Sensitization is key to enabling young consumers to become equal participants during the co-design process. Sensitization allowed the participants to engage in the design task in a playful manner, which fostered active participation and creative insights during the co-design session. A team approach based on interactivity and group autonomy enabled adolescents to contribute insights into their specific needs and wants. This was complemented by a trusting environment and the presence of immediately available yet “hands off” facilitators.

Research limitations/implications
The findings are limited to one specific sample and design task. Future research is required that investigates co-design with young consumers in different contexts.

Practical implications
This paper provides guidance for the application of co-design with young consumers by highlighting the importance of sensitization and facilitation.

Originality/value
This study marks one of the first approaches to co-designing alcohol education programs, including VR components, with young consumers. The findings contribute to a better understanding of the consequences of involving young consumers through co-design.
Navigating the new, transplanted self: how recipients manage the cognitive risks of organ transplantation
Authors: Cormier Nicholas R. , Gallo‐Cruz Selina R. , Beard Renee L. 
Published: October 2017

AbstractThe physiological risks of organ transplantation are well documented, but more poorly understood are the sociological ways in which organ recipients redefine themselves in reaction to physiological risks and social changes accompanying transplantation. This article analyses transplantation as a procedure that is not only physiologically risky but also poses risk to the social identity of the recipient, and explores how transplant recipients cognitively navigate transplantation surgery from waiting for to recovering after a transplant. It builds on previous sociological exploration of risk as a socially constructed process mediating experiences of health and illness with a focused contribution on explaining how individuals navigate risks posed to their social identities by major biophysical transformations. This article pointedly analyses narratives of fourteen organ recipients and the four dominant phases of identity management that emerged to create what we have coined as the new ‘transplanted self’, indicating the varied ways the individual social self emerges in response to the social risks of transplantation. We conclude that a better understanding of the recipient experience will contribute to improved care in the transplantation field.
Changes in status and paradigms? On subject pronouns in medieval french
Authors: Zimmermann Michael 
Published: October 2017

AbstractThis paper addresses the debate on the morpho‐syntactic status of subject pronouns in the pre‐modern stages of the French language by reinvestigating this issue along with that of the number of paradigms of such elements. On the basis of a collection of the various evidence provided in the literature as well as hitherto ignored and novel empirical insights, the paper discusses the different views put forward and essentially argues that, in its medieval stages, French had two paradigms of, respectively, strong and phonologically clitic subject pronouns. From this finding as well as standard assumptions on the modern (standard) stage of the language the paper eventually concludes that, diachronically, French evinces continuity, rather than changes regarding the two issues under investigation.
God of the hinge: treating LGBTQIA patients
Authors: Boland Annie 
Published: October 2017

AbstractThis paper looks at systems of gender within the context of analysis. It explores the unique challenges of individuation faced by transsexual, transgender, gender queer, gender non‐conforming, cross‐dressing and intersex patients. To receive patients generously we need to learn how a binary culture produces profound and chronic trauma. These patients wrestle with being who they are whilst simultaneously receiving negative projections and feeling invisible. While often presenting with the struggles of gender conforming individuals, understanding the specifically gendered aspect of their identity is imperative. An analyst's unconscious bias may lead to iatrogenic shaming.The author argues that rigorous, humble inquiry into the analyst's transphobia can be transformative for patient, analyst, and the work itself. Analysis may, then, provide gender‐variant patients with their first remembered and numinous experience of authentic connection to self. Conjuring the image of a hinge, securely placed in the neutral region of a third space, creates a transpositive analytic temenos. Invoking the spirit of the Trickster in the construction of this matrix supports the full inclusion of gender‐variant patients. Nuanced attunement scaffolds mirroring and the possibility of play. Being mindful that gender is sturdy and delicate as well as mercurial and defined enriches the analyst's listening.
Total Ion Spectra versus Segmented Total Ion Spectra as Preprocessing Tools for Gas Chromatography – Mass Spectrometry Data
Authors: Adutwum Lawrence A. , Abel Robin J. , Harynuk James 
Published: October 2017

AbstractAlignment of fire debris data from GC‐MS for chemometric analysis is challenged by highly variable, uncontrolled sample and matrix composition. The total ion spectrum (TIS) obviates the need for alignment but loses all separation information. We introduce the segmented total ion spectrum (STIS), which retains the advantages of TIS while retaining some retention information. We compare the performance of STIS with TIS for the classification of casework fire debris samples. TIS and STIS achieve good model prediction accuracies of 96% and 98%, respectively. Baseline removal improved model prediction accuracies for both TIS and STIS to 97% and 99%, respectively. The importance of maintaining some chromatographic information to aid in deciphering the underlying chemistry of the results and reasons for false positive/negative results was also examined.
Sirtuins at the crossroads of stemness, aging, and cancer
Authors: O'Callaghan Carol , Vassilopoulos Athanassios 
Published: October 2017

SummarySirtuins are stress‐responsive proteins that direct various post‐translational modifications (PTMs) and as a result, are considered to be master regulators of several cellular processes. They are known to both extend lifespan and regulate spontaneous tumor development. As both aging and cancer are associated with altered stem cell function, the possibility that the involvement of sirtuins in these events is mediated by their roles in stem cells is worthy of investigation. Research to date suggests that the individual sirtuin family members can differentially regulate embryonic, hematopoietic as well as other adult stem cells in a tissue‐ and cell type‐specific context. Sirtuin‐driven regulation of both cell differentiation and signaling pathways previously involved in stem cell maintenance has been described where downstream effectors involved determine the biological outcome. Similarly, diverse roles have been reported in cancer stem cells (CSCs), depending on the tissue of origin. This review highlights the current knowledge which places sirtuins at the intersection of stem cells, aging, and cancer. By outlining the plethora of stem cell‐related roles for individual sirtuins in various contexts, our purpose was to provide an indication of their significance in relation to cancer and aging, as well as to generate a clearer picture of their therapeutic potential. Finally, we propose future directions which will contribute to the better understanding of sirtuins, thereby further unraveling the full repertoire of sirtuin functions in both normal stem cells and CSCs.
Endogeneity of Return Parameters and Portfolio Selection: An Analysis on Implied Covariances
Authors: Park Koohyun , Rhee Thomas 
Published: October 2017

AbstractThe paper presents a method to measure forward‐looking covariance risk for any two assets even when the explicit market for barter trades does not exist. We argue that the terms of trade in any barter exchanges also follow a martingale process with no arbitrage. We then compute various bivariate martingale probabilities for different assets to value all possible pseudo exchange options. This makes it possible for one to compute implied covariances embedded in the value of any exchange options as in Margrabe (1978). The paper also discusses how these “recoverable” implied return distribution parameters can impact portfolio choice.
White‐tailed deer as the last megafauna dispersing seeds in Neotropical dry forests: the role of fruit and seed traits
Authors: Jara‐Guerrero Andrea , Escribano‐Avila Gema , Espinosa Carlos Iván , De la Cruz Marcelino , Méndez Marcos 
Published: October 2017

AbstractEndozoochory is a prominent form of seed dispersal in tropical dry forests. Most extant megafauna that perform such seed dispersal are ungulates, which can also be seed predators. White‐tailed deer (Odocoileus virginianus) is one of the last extant megafauna of Neotropical dry forests, but whether it serves as a legitimate seed disperser is poorly understood. We studied seed dispersal patterns and germination after white‐tailed deer gut passage in a tropical dry forest in southwest Ecuador. Over 23 mo, we recorded ca 2000 seeds of 11 species in 385 fecal samples. Most seeds belonged to four species of Fabaceae: Chloroleucon mangense, Senna mollissima, Piptadenia flava, and Caesalpinia glabrata. Seeds from eight of the 11 species dispersed by white‐tailed deer germinated under controlled conditions. Ingestion did not affect germination of C. mangense and S. mollissima, whereas C. glabrata showed reduced germination. Nevertheless, the removal of fruit pulp resulting from ingestion by white‐tailed deer could have a deinhibition effect on germination due to seed release. Thus, white‐tailed deer play an important role as legitimate seed dispersers of woody species formerly considered autochorous. Our results suggest that more research is needed to fully understand the ecological and evolutionary effects of the remaining extant megafauna on plant regeneration dynamics in the dry Neotropics.
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design
Authors: Zhang Min , Jiang Zhiteng , Chen Sheng , Wu Zhixiang , Chen Kai , Wu Yeming 
Published: October 2017

Neuroblastoma (NB) is a highly malignant solid tumor in children. The cysteine endopeptidase legumain is expressed in adult solid tumors, but its expression in NB has not been examined. In this study, we assayed legumain expression in two NB cell lines and in microarrays of tumor tissues collected from 46 children with undifferentiated NB, differentiated NB, and ganglioneuroblastoma. Correlation analyses showed that legumain was expressed in all NB cell lines tested and that expression correlated with the degree of tumor differentiation. The efficacy, specificity, and toxicity of EMC‐AANL‐DOX, a novel doxorubicin‐based legumain‐activated prodrug, were then evaluated in mouse model of NB. Compared with DOX, EMC‐AANL‐DOX showed greater inhibition of tumor growth and a lower toxicity at high doses. Neither leukocyte or platelet counts nor renal function or cardiac anatomy differed significantly between the EMC‐AANL‐DOX and control groups (p > .05), suggesting that the prodrug caused minimal bone marrow depression and did not induce renal or cardiac damage. The good specificity and efficacy of EMC‐AANL‐DOX and low toxicity recommend its use in the treatment of NB. Correlation analyses of NB differentiation and legumain expression may reveal a novel anti‐tumor‐related functions of the drug and a new strategy for the treatment of pediatric solid tumors.
TNFα and IL‐17A are differentially expressed in psoriasis‐like vs eczema‐like drug reactions to TNFα antagonists
Authors: Deubelbeiss Cornelia , Kolios Antonios G. A. , Anzengruber Florian , French Lars E. , Yawalkar Nikhil , Kempf Werner , Kerl Katrin , Meier Barbara , Navarini Alexander A. 
Published: October 2017

BackgroundTumor necrosis factor α (TNFα) blocking drugs are in use for a wide range of autoimmune disorders. In up to 5% of patients, this class of drugs produces puzzling cutaneous side effects that are the subject of this investigation, namely psoriasiform and eczema‐like skin inflammation. These side effects can occur after any time of treatment and regardless of the underlying disorders. The exact pathophysiology is as yet unknown.MethodsA total of 33 patients (19 female, average age 52 years) who had a cutaneous reaction to infliximab, adalimumab or etanercept were included. The type of inflammatory reaction was determined, and the corresponding cytokine expression was evaluated by immunohistochemistry for TNFα, IL‐1β, IL‐22, IL‐6, IL‐17A, IL33, IL‐8 and IL‐36α (semi‐quantitative grading system from − to ++++). In addition, RNA expression levels of IL‐17A and TNFα were confirmed by quantitative real‐time PCR.ResultsIL‐17A (P < .039) and TNFα (P < .008) were expressed at significantly higher levels in psoriasis or pustular‐like reactions (PPR) compared to eczematous‐like reactions (ELR). There was no significant difference in the expression of IL‐1β, IL‐22, IL‐6, IL‐33, IL‐8 and IL‐36α between PPR and ELR.ConclusionTNFα and IL‐17A are both cytokines known to be involved in psoriasis but less so in non‐psoriasiform dermatitis or eczema. Therefore, their overexpression in PPR is plausible and suggests that the pathogenesis of PPR mirrors at least in part those of psoriasis. Further investigations will define the exact role of these cytokines in rare cutaneous side effects of anti‐TNFα therapy. Our results suggest that IL‐17A inhibition could be a therapeutic option in patients with anti‐TNF induced psoriasis.
Folliculocystic and collagen hamartoma of tuberous sclerosis: A new case in a female patient and review of literature
Authors: Kaplan Laura , Kazlouskaya Viktoryia , Ugorji Rex , Heilman Edward , Siegel Daniel M. , Glick Sharon A. 
Published: October 2017

Folliculocystic and collagen hamartoma (FCCH) of tuberous sclerosis is a rare entity described in 2012 by Torrelo et al. with only 8 cases described, predominantly in males. It presents since birth or early infancy and in the majority of cases is associated with tuberous sclerosis. The hamartoma presents as an exophytic plaque and has distinctive histopathological features including hair follicles, intact or ruptured epidermal cysts, and an increased number of collagen fibers extending to the subcutaneous tissue.Herein we present an additional case of this rare entity in an 18‐year‐old female who met clinical criteria for tuberous sclerosis. The patient had an exophytic mass in the left temporal area for many years and wanted surgical excision due to its cosmetic appearance. Histopathology of the surgical specimen showed a hamartomatous lesion with multiple large intact epidermal cysts, hairs and increased thickened collagen. The patient has followed up for 1 year after the excision, with no recurrence. Additionally, we provide a literature review of known cases of FCCH as well as its clinical and histopathological differential diagnosis.