bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parcours thérapeutique en EMDR d’une jeune adulte victime d’inceste
Authors: Amara P. 
Published: November 2015

Mise au point en 1989 par Francine Shapiro, la thérapie EMDR (Eye Movement Desensitization and Reprocessing) est la thérapie recommandée pour le traitement des troubles psychotraumatiques. Basée sur le principe d’une stimulation bilatérale alternée gauche-droite, par mouvements oculaires, stimuli tactiles ou auditifs, alors que le patient est focalisé sur le souvenir chargé d’affects non intégrés, l’EMDR permet de résorber les symptômes de reviviscence et d’évitement, ainsi que l’activation neurovégétative, caractéristiques du trouble post-traumatique. Le contexte particulier, fréquemment rencontré dans les consultations de psychotraumatologie, de révélations tardives de vécus d’agressions sexuelles dans l’enfance, engage une situation psychique spécifique ; en effet, si l’enfant agressé n’a pu révéler les faits, c’est qu’il vivait dans un contexte familial hautement dysfonctionnel, organisant a minima une impossibilité de parler et, si c’est un cas d’inceste, une absence de protection et de limites intergénérationnelles. Le psychisme du sujet adulte est toujours porteur de ces effractions irreprésentables, qui ont entravé la construction identitaire et maintiennent des contenus psychiques marqués par la peur et la sidération. La révélation des faits à l’âge adulte, qui peut avoir lieu de façon inattendue lors d’une levée de l’amnésie infantile par la mobilisation psychique des contenus inconscients engendrée par l’EMDR, amène de ce fait un remaniement psychique complexe à accompagner. Nous nous attacherons à exposer la dynamique thérapeutique mise en jeu à travers 4 axes concomitants d’évolution que le thérapeute soutient, canalise et accompagne : l’évolution de la symptomatologie, y compris la symptomatologie dépressive reliée à la perte des imago parentales ; la mutation des représentations psychiques mises au défi de passer de celles d’un enfant mutique et terrorisé, à celles d’un adulte assumant d’avoir été l’enfant de ces parents-là ; le changement dans les comportements afférents à la sphère familiale et plus largement relationnelle ; le maintien et la protection des acquis.
Anorexie du garçon, une clinique spécifique ?
Authors: Chambry J. 
Published: November 2015

L’incidence de l’anorexie mentale masculine est estimée aux alentours de 0,18/100 000 habitants/an à partir des registres d’admission en psychiatrie mais la prévalence est incertaine en raison du peu d’études en population générale avec des résultats allant de 0 à 0,09 %. La conduite anorexique chez le garçon associe restriction alimentaire, hyperactivité physique, vomissements et abus de laxatifs. Les garçons anorexiques sont imprégnés d’images masculines de sveltesse, obtenues à grand renfort de musculation et de pratique sportive. Les complications somatiques (anémie, hypotension, ostéoporose) classiquement décrites chez les filles sont également présentes chez les hommes. L’âge de début du trouble alimentaire se situe entre 16 et 19 ans, ce qui fait de cette maladie une pathologie de l’adolescence. L’évolution est le plus souvent longue. Il est classique de retenir le chiffre d’un garçon pour dix filles mais la seule étude en population générale retrouve des chiffres beaucoup plus élevés. Un sur deux en ce qui concerne les formes complètes ou partielles un quart pour les seules formes complètes. Les aspects comportementaux plaident pour une similitude entre l’anorexie mentale masculine et féminine même si les formes anorexiques restrictives pures sont plus rares. Les plaintes des hommes au sujet de leur poids, de leur forme corporelle sont assez différentes de celles de femmes anorexiques. Ils expriment un désir de perdre leur « graisse » afin de parvenir à une définition classique de l’homme musclé. Ainsi, l’anorexie mentale existe aussi chez les hommes. Son expression symptomatologique est très proche des formes féminines, mais diffère par quelques aspects, entre autres par l’obsession d’un corps musclé. Il existe moins de travaux chez les garçons. Sur le plan narcissique, il semblerait que la fragilité identitaire soit plus grande, ce qui a fait penser que l’anorexie mentale masculine était plus fréquemment un équivalent psychotique. Au niveau œdipien, les identifications sexuées apparaissent plus complexes. Il existerait en effet chez ces garçons, des difficultés d’identification masculine importante et à une crainte du féminin en eux même. À partir de l’étude de 15 cas d’adolescents et de jeunes hommes souffrant d’anorexie mentale, se dégagent deux profils psychopathologiques. Certains semblent présenter une organisation névrotique fragile marquée par un complexe d’Œdipe inversé. D’autres au contraire semblent utiliser le symptôme anorexique comme un dernier rempart contre l’effondrement psychotique. Ainsi, l’anorexie mentale du garçon pourrait nous révéler que certains hommes utilisent leur corps comme support de leur identité sexuée. La fragilité identitaire ainsi révélée doit être masquée par un corps qui renvoie une image de soi supportable qui vient réparer le vide de la construction psychique, le défaut de symbolique. Cependant, cette problématique fait écho, à notre avis à l’évolution sociétale qui tend à nier les différences hommes/femmes, faire disparaître la notion de genre au profit d’un narcissisme tout puissant.
Obesity has an impact on outcome in lumbar disc surgery
Authors: Järvimäki Voitto , Kautiainen Hannu , Haanpää Maija , Alahuhta Seppo , Vakkala Merja 
Published: November 2015

ABSTRACT

Purpose
To investigate the effect of obesity on outcome in lumbar discectomy.

Methods
A cross-sectional postal survey; a self-made questionnaire, Beck depression inventory IA (BDI IA) and the Oswestry low back disability questionnaire (ODI) were sent to the patients, who had undergone lumbar disc surgery in the Oulu University Hospital between June 2005 and May 2008. Patients were divided into three groups according to BMI: normal, pre-obese and obese. The ODI was also examined in the framework of the international classification of functioning, disability and health (ICF) to investigate its ability to describe various dimensions of functioning (body structure and functions, activities and participation).

Results
The postal survey was sent to 642 patients, of whom 355 (55%) replied. Males dominated in the pre-obese (66%) and obese (62%) groups (p = 0.01). Normal-weighted and pre-obese patients had lower BDI scores compared to obese patients (mean BDI: 8.0, 7.6,11.2, respectively, p = 0.035). Total ODI score was highest in the obese group compared to normal-weighted or pre-obese (20.3,18.6,26.4, respectively, p = 0.011). When ODI was linked to the ICF there were significant differences in all activity domains (mobility, self-care and interpersonal interactions and relationships) and the mobility component of the participation domain between the weight groups.

Conclusions and implications
Obesity has an impact on outcome in lumbar discectomy. Obese patients had higher scores in BDI and ODI indicating mild mood disturbances and moderate functional disability. According to ICF, functional disability of obese patients was observed to some extent in all activity domains. Obese patients will be more frequently present for disc surgery and increased morbidity risk must be recognized. We need a strategy to rehabilitate and activate obese patients pre- and postoperatively.
Foreign Direct Investment in the Pharmaceutical Industry: Why Singapore and not Hong Kong
Authors: MERCURIO Bryan , KIM Daria 
Published: November 2015

AbstractThis article began as mere curiosity over what appeared to be a paradox – Singapore and Hong Kong share countless economic and geopolitical similarities and compete vigorously for foreign direct investment (FDI), yet only the former has become a pharmaceutical hub while the latter struggles to attract any FDI in the sector. To find the reason for the “drastic” difference in pharmaceutical FDI, we compare the economic, legal, policy, and regulatory frameworks of the two jurisdictions focusing on the factors that have been identified in the economic literature as having the most relevance for FDI decision-making. The analysis discounts economic and legal factors before finding variances in policy and regulatory frameworks as the critical difference accounting for the disparity in the pharmaceutical FDI. Given that Hong Kong occasionally considers transforming itself into the “pharmaceutical centre for the Asia-Pacific”, this article calls for a change in policy approach and strategy before this aspiration is considered more realistically.
Recovery of the Critically Endangered Hainan gibbonNomascus hainanus
Authors: Deng Huaiqing , Zhang Mingxia , Zhou Jiang 
Published: November 2015

AbstractThe Critically Endangered Hainan gibbonNomascus hainanusis one of the most threatened primate species and is now found only in the Bawangling National Nature Reserve of Hainan Province, China. We describe changes in population dynamics, and the current number of individuals, based on historical sources and fieldwork during 2002–2013. The population comprises a total of 20 individuals (including six solitary males) in three separate groups. All are confined to an area of c. 16 km2. The current population developed from two groups that comprised a total of 13 individuals in 2002, and has increased slowly since then, with the addition of one new group. Population increase is hindered by the gibbon's unique social structure of one adult male and two adult females, as well as the reproductive age limit in adult females. An imbalance in the sex ratio of offspring may also have hindered population recovery but further investigation of this is required. Our findings indicate that the Hainan gibbon is likely to remain Critically Endangered in the coming decades.
Closed form Newton–Euler dynamic model of flexible manipulators
Authors: Bascetta Luca , Ferretti Gianni , Scaglioni Bruno 
Published: November 2015

SUMMARYIn this paper, a closed-form dynamic model of flexible manipulators is developed, based on the Newton–Euler formulation of motion equations of flexible links and on the adoption of the spatial vector notation. The proposed model accounts for two main innovations with respect to the state of the art: it is obtained in closed form with respect to the joints and modal coordinates (including the quadratic velocity terms) and motion equations of the whole manipulator can be computed for any arbitrary shape of the links and any possible link cardinality starting from the output of several commercial (finite element analysis) FEA codes. The Newton–Euler formulation of motion equations in terms of the joint and elastic variables greatly improves the simulation performances and makes the model suitable for real-time control and active vibration damping. The model has been compared with literature benchmarks obtained by the classical multibody approach and further validated by comparison with experiments collected on an experimental manipulator.
Equity in health care financing in Portugal: findings from the Household Budget Survey 2010/2011
Authors: Quintal Carlota , Lopes José 
Published: November 2015

AbstractEquity in health care financing is recognised as a main goal in health policy. It implies that payments should be linked to capacity to pay and that households should be protected against catastrophic health expenditure (CHE). The risk of CHE is inversely related to the share of out-of-pocket payments (OOP) in total health expenditure. In Portugal, OOP represented 26% of total health expenditure in 2010 [one of the highest among Organisation for Economic Co-operation and Development (OECD) countries]. This study aims to identify the proportion of households with CHE in Portugal and the household factors associated with this outcome. Additionally, progressivity indices are calculated for OOP and private health insurance. Data were taken from the Portuguese Household Budget Survey 2010/2011. The prevalence of CHE is 2.1%, which is high for a developed country with a universal National Health Service. The main factor associated with CHE is the presence of at least one elderly person in households (when the risk quadruples). Payments are particularly regressive for medicines. Regarding the results by regions, the Kakwani index for total OOP is larger (negative) for the Centre and lower, not significant, for the Azores. Payments for voluntary health insurance are progressive.
Realization of a vertical topological p–n junction in epitaxial Sb2Te3/Bi2Te3 heterostructures
Authors: Eschbach Markus , Młyńczak Ewa , Kellner Jens , Kampmeier Jörn , Lanius Martin , Neumann Elmar , Weyrich Christian , Gehlmann Mathias , Gospodarič Pika , Döring Sven , Mussler Gregor , Demarina Nataliya , Luysberg Martina , Bihlmayer Gustav , Schäpers Thomas , Plucinski Lukasz , Blügel Stefan , Morgenstern Markus , Schneider Claus M. , Grützmacher Detlev 
Published: November 2015

AbstractThree-dimensional (3D) topological insulators are a new state of quantum matter, which exhibits both a bulk band structure with an insulating energy gap as well as metallic spin-polarized Dirac fermion states when interfaced with a topologically trivial material. There have been various attempts to tune the Dirac point to a desired energetic position for exploring its unusual quantum properties. Here we show a direct experimental proof by angle-resolved photoemission of the realization of a vertical topological p–n junction made of a heterostructure of two different binary 3D TI materials Bi2Te3 and Sb2Te3 epitaxially grown on Si(111). We demonstrate that the chemical potential is tunable by about 200 meV when decreasing the upper Sb2Te3 layer thickness from 25 to 6 quintuple layers without applying any external bias. These results make it realistic to observe the topological exciton condensate and pave the way for exploring other exotic quantum phenomena in the near future.
Transient misfolding dominates multidomain protein folding
Authors: Borgia Alessandro , Kemplen Katherine R. , Borgia Madeleine B. , Soranno Andrea , Shammas Sarah , Wunderlich Bengt , Nettels Daniel , Best Robert B. , Clarke Jane , Schuler Benjamin 
Published: November 2015

AbstractNeighbouring domains of multidomain proteins with homologous tandem repeats have divergent sequences, probably as a result of evolutionary pressure to avoid misfolding and aggregation, particularly at the high cellular protein concentrations. Here we combine microfluidic-mixing single-molecule kinetics, ensemble experiments and molecular simulations to investigate how misfolding between the immunoglobulin-like domains of titin is prevented. Surprisingly, we find that during refolding of tandem repeats, independent of sequence identity, more than half of all molecules transiently form a wide range of misfolded conformations. Simulations suggest that a large fraction of these misfolds resemble an intramolecular amyloid-like state reported in computational studies. However, for naturally occurring neighbours with low sequence identity, these transient misfolds disappear much more rapidly than for identical neighbours. We thus propose that evolutionary sequence divergence between domains is required to suppress the population of long-lived, potentially harmful misfolded states, whereas large populations of transient misfolded states appear to be tolerated.
Auditory sequence processing reveals evolutionarily conserved regions of frontal cortex in macaques and humans
Authors: Wilson Benjamin , Kikuchi Yukiko , Sun Li , Hunter David , Dick Frederic , Smith Kenny , Thiele Alexander , Griffiths Timothy D. , Marslen-Wilson William D. , Petkov Christopher I. 
Published: November 2015

AbstractAn evolutionary account of human language as a neurobiological system must distinguish between human-unique neurocognitive processes supporting language and evolutionarily conserved, domain-general processes that can be traced back to our primate ancestors. Neuroimaging studies across species may determine whether candidate neural processes are supported by homologous, functionally conserved brain areas or by different neurobiological substrates. Here we use functional magnetic resonance imaging in Rhesus macaques and humans to examine the brain regions involved in processing the ordering relationships between auditory nonsense words in rule-based sequences. We find that key regions in the human ventral frontal and opercular cortex have functional counterparts in the monkey brain. These regions are also known to be associated with initial stages of human syntactic processing. This study raises the possibility that certain ventral frontal neural systems, which play a significant role in language function in modern humans, originally evolved to support domain-general abilities involved in sequence processing.
Insight into 2α-Chloro-2′(2′,6′)-(Di)Halogenopicropodophyllotoxins Reacting with Carboxylic Acids Mediated by BF3·Et2O
Authors: Fan Lingling , Zhi Xiaoyan , Che Zhiping , Xu Hui 
Published: November 2015

AbstractStereospecific nucleophilic substitution at the C-4α position of 2α-chloro-2′(2′,6′)-(di)halogenopicropodophyllotoxin derivatives with carboxylic acids mediated by BF3·Et2O was described. Interestingly, this stereoselective products were completely controlled by the reaction time. That is, if the reaction time was prolonged to 24.5–31 h, the resulting compounds were all transformed into the unusual C-ring aromatization products. Additionally, it demonstrated that BF3·Et2O and reaction temperature were the important factors for C-ring aromatization and AlCl3 could be substituted for BF3·Et2O as a lewis acid for C-ring aromatization. Halogenation of E-ring of 2β-chloropodophyllotoxins with NCS or NBS also led to the same C-ring aromatization compounds. Especially compounds 5c, 6g and 7b exhibited insecticidal activity equal to that of toosendanin.
Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome
Authors: Osakabe Akihisa , Tachiwana Hiroaki , Kagawa Wataru , Horikoshi Naoki , Matsumoto Syota , Hasegawa Mayu , Matsumoto Naoyuki , Toga Tatsuya , Yamamoto Junpei , Hanaoka Fumio , Thomä Nicolas H. , Sugasawa Kaoru , Iwai Shigenori , Kurumizaka Hitoshi 
Published: November 2015

AbstractUV-DDB, an initiation factor for the nucleotide excision repair pathway, recognizes 6–4PP lesions through a base flipping mechanism. As genomic DNA is almost entirely accommodated within nucleosomes, the flipping of the 6–4PP bases is supposed to be extremely difficult if the lesion occurs in a nucleosome, especially on the strand directly contacting the histone surface. Here we report that UV-DDB binds efficiently to nucleosomal 6–4PPs that are rotationally positioned on the solvent accessible or occluded surface. We determined the crystal structures of nucleosomes containing 6–4PPs in these rotational positions and found that the 6–4PP DNA regions were flexibly disordered, especially in the strand exposed to the solvent. This characteristic of 6–4PP may facilitate UV-DDB binding to the damaged nucleosome. We present the first atomic-resolution pictures of the detrimental DNA cross-links of neighboring pyrimidine bases within the nucleosome and provide the mechanistic framework for lesion recognition by UV-DDB in chromatin.
Role of KRAS-LCS6 polymorphism in advanced NSCLC patients treated with erlotinib or docetaxel in second line treatment (TAILOR)
Authors: Ganzinelli Monica , Rulli Eliana , Caiola Elisa , Garassino Marina Chiara , Broggini Massimo , Copreni Elena , Piva Sheila , Longo Flavia , Labianca Roberto , Bareggi Claudia , Fabbri Maria Agnese , Martelli Olga , Fagnani Daniele , Locatelli Maria Cristina , Bertolini Alessandro , Valmadre Giuseppe , Pavese Ida , Calcagno Anna , Sarobba Maria Giuseppa , Marabese Mirko 
Published: November 2015

AbstractMicroRNAs were described to target mRNA and regulate the transcription of genes involved in processes de-regulated in tumorigenesis, such as proliferation, differentiation and survival. In particular, the miRNA let-7 has been suggested to regulate the expression of the KRAS gene, a common mutated gene in non-small cell lung cancer (NSCLC), through a let-7 complementary site (LCS) in 3′UTR of KRAS mRNA. We have reported the analysis performed on the role of the polymorphism located in the KRAS-LCS (rs61764370) which is involved in the disruption of the let-7 complementary site in NSCLC patients enrolled within the TAILOR trial, a randomised trial comparing erlotinib versus docetaxel in second line treatment. In our cohort of patients, KRAS-LCS6 polymorphism did not have any impact on both overall survival (OS) and progression free survival (PFS) and was not associated with any patient’s baseline characteristics included in the study. Overall, patients had a better prognosis when treated with docetaxel instead of erlotinib for both OS and PFS. Considering KRAS-LCS6 status, the TG/GG patients had a benefit from docetaxel treatment (HR(docetaxel vs erlotinib) = 0.35, 95% CI 0.15–0.79, p = 0.011) compared with the TT patients (HR(docetaxel vs erlotinib) = 0.72, 95% CI 0.52–1.01, p = 0.056) in terms of PFS.
Gamma oscillations in V1 are correlated with GABAA receptor density: A multi-modal MEG and Flumazenil-PET study
Authors: Kujala Jan , Jung Julien , Bouvard Sandrine , Lecaignard Françoise , Lothe Amélie , Bouet Romain , Ciumas Carolina , Ryvlin Philippe , Jerbi Karim 
Published: November 2015

AbstractHigh-frequency oscillations in the gamma-band reflect rhythmic synchronization of spike timing in active neural networks. The modulation of gamma oscillations is a widely established mechanism in a variety of neurobiological processes, yet its neurochemical basis is not fully understood. Modeling,in-vitroandin-vivoanimal studies suggest that gamma oscillation properties depend on GABAergic inhibition. In humans, search for evidence linking total GABA concentration to gamma oscillations has led to promising -but also to partly diverging- observations. Here, we provide the first evidence of a direct relationship between the density of GABAAreceptors and gamma oscillatory gamma responses in human primary visual cortex (V1). By combining Flumazenil-PET (to measure resting-levels of GABAAreceptor density) and MEG (to measure visually-induced gamma oscillations), we found that GABAAreceptor densities correlated positively with the frequency and negatively with amplitude of visually-induced gamma oscillations in V1. Our findings demonstrate that gamma-band response profiles of primary visual cortex across healthy individuals are shaped by GABAA-receptor-mediated inhibitory neurotransmission. These results bridge the gap within-vitroand animal studies and may have future clinical implications given that altered GABAergic function, including dysregulation of GABAAreceptors, has been related to psychiatric disorders including schizophrenia and depression.