bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dermatophagoides pteronyssinus immunotherapy changes the T-regulatory cell activity
Authors: Gonzalez M. , Doña I. , Palomares F. , Campo P. , Rodriguez M. J. , Rondon C. , Gomez F. , Fernandez T. D. , Perkins J. R. , Escribese M. M. , Torres M. J. , Mayorga C. 
Published: September 2017

AbstractSubcutaneous specific immunotherapy (SCIT) has been shown to modify theDermatophagoides pteronissinus(DP) allergic response, characterized by generation of Treg cells. However, studies have reported no changes in the proportion of Treg cells after immunotherapy, indicating that the effects may be due to modifications in their regulatory activities. We aimed to determine whether Tregs generated by DP-SCIT can switch the allergic response to tolerant and study the involvement of suppressive cytokines on it. Twenty-four DP-allergic rhinitis patients were recruited, 16 treated with DP-SCIT and 8 untreated. Treg and T effector cells were isolated before and after DP-SCIT, and cocultured in different combinations with α-IL-10, α-TGF-β blocking antibodies and nDer p 1. Treg cells after DP-SCIT increased Th1 and decreased Th2 and Th9 proliferation. Similarly, they increased IL-10 and decreased IL-4 and IL-9-producing cells. α-IL-10 affected the activity of Treg cells obtained after DP-SCIT only. Finally, DP-specific IgG4 levels, Treg percentage and IL-10 production were correlated after DP-SCIT. These results demonstrate that DP-SCIT induces Treg cells with different suppressive activities. These changes could be mediated by IL-10 production and appear to play an important role in the induction of the tolerance response leading to a clinical improvement of symptoms.
Correlation between social proximity and mobility similarity
Authors: Fan Chao , Liu Yiding , Huang Junming , Rong Zhihai , Zhou Tao 
Published: September 2017

AbstractHuman behaviors exhibit ubiquitous correlations in many aspects, such as individual and collective levels, temporal and spatial dimensions, content, social and geographical layers. With rich Internet data of online behaviors becoming available, it attracts academic interests to explore human mobility similarity from the perspective of social network proximity. Existent analysis shows a strong correlation between online social proximity and offline mobility similarity, namely, mobile records between friends are significantly more similar than between strangers, and those between friends with common neighbors are even more similar. We argue the importance of the number and diversity of common friends, with a counter intuitive finding that the number of common friends has no positive impact on mobility similarity while the diversity plays a key role, disagreeing with previous studies. Our analysis provides a novel view for better understanding the coupling between human online and offline behaviors, and will help model and predict human behaviors based on social proximity.
Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome
Authors: Kida Hiroshi , Takahashi Tomoyuki , Nakamura Yuki , Kinoshita Takashi , Hara Munetsugu , Okamoto Masaki , Okayama Satoko , Nakamura Keiichiro , Kosai Ken-ichiro , Taniwaki Takayuki , Yamashita Yushiro , Matsuishi Toyojiro 
Published: September 2017

AbstractRett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding protein 2 (MeCP2), located on the X chromosome. Many RTT patients have breathing abnormalities, such as apnea and breathing irregularity, and respiratory infection is the most common cause of death in these individuals. Previous studies showed that MeCP2 is highly expressed in the lung, but its role in pulmonary function remains unknown. In this study, we found that MeCP2 deficiency affects pulmonary gene expression and structures. We also found that Mecp2-null mice, which also have breathing problems, often exhibit inflammatory lung injury. These injuries occurred in specific sites in the lung lobes. In addition, polarizable foreign materials were identified in the injured lungs of Mecp2-null mice. These results indicated that aspiration might be a cause of inflammatory lung injury in Mecp2-null mice. On the other hand, MeCP2 deficiency affected the expression of several neuromodulator genes in the lower brainstem. Among them, neuropeptide substance P (SP) immunostaining was reduced in Mecp2-null brainstem. These findings suggest that alteration of SP expression in brainstem may be involved in autonomic dysregulation, and may be one of the causes of aspiration in Mecp2-null mice.
Cytochalasan and Tyrosine-Derived Alkaloids from the Marine Sediment-Derived Fungus Westerdykella dispersa and Their Bioactivities
Authors: Xu Dan , Luo Minghe , Liu Fenglou , Wang Dong , Pang Xuejiao , Zhao Ting , Xu Lulin , Wu Xia , Xia Mingyu , Yang Xiaolong 
Published: September 2017

AbstractSix new cytochalasans, designated as 18-oxo-19,20-dihydrophomacin C (1), 18-oxo-19-methoxy-19,20- dihydrophomacin C (2), 18-oxo-19-hydroxyl-19,20-dihydrophomacin C (3), 19,20-dihydrophomacin C (4), 19-methoxy-19,20-dihydrophomacin C (5), 19-hydroxyl-19,20-dihydrophomacin C (6), and one new tyrosine-derived alkaloid named as gymnastatin Z (8), together with two known compounds, phomacin B (7) and triticone D (9), were isolated from a solid-substrate fermentation culture of Westerdykella dispersa which was derived from marine sediments. Their structures were established on the basis of spectroscopic analysis using 1D and 2D NMR techniques, and comparison of NMR data to those of known compounds. The anti-bacterial and cytotoxic activities assays of all isolated compounds were evaluated against eight human pathogenic bacteria and five human cancer cell lines, respectively. Compound 8 exhibited moderate activity against B. subtilis with MIC values of 12.5 µg/mL, while compounds 5, 7 and 8 displayed moderate inhibitory activities against five human cancer cell lines (MCF-7, HepG2, A549, HT-29 and SGC-7901), with IC50 values ranging from 25.6 to 83.7 µM.
RORα2 requires LSD1 to enhance tumor progression in breast cancer
Authors: Kim Kyeongkyu , Lee Ji Min , Yu Young Suk , Kim Hyunkyung , Nam Hye Jin , Moon Hyeong-Gon , Noh Dong-Young , Kim Keun Il , Fang Sungsoon , Baek Sung Hee 
Published: September 2017

AbstractRetinoic acid-related orphan receptor α (RORα) regulates diverse physiological processes, including inflammatory responses, lipid metabolism, circadian rhythm, and cancer biology. RORα has four different isoforms which have distinct N-terminal domains but share identical DNA binding domain and ligand binding domain in human. However, lack of specific antibody against each RORα isoform makes biochemical studies on each RORα isoform remain unclear. Here, we generate RORα2-specific antibody and characterize the role of RORα2 in promoting tumor progression in breast cancer. RORα2 requires lysine specific demethylase 1 (LSD1/KDM1A) as a coactivator for transcriptional activation of RORα2 target genes, exemplified by CTNND1. Intriguingly, RORα2 and LSD1 protein levels are dramatically elevated in human breast cancer specimens compared to normal counterparts. Taken together, our studies indicate that LSD1-mediated RORα2 transcriptional activity is important to promote tumor cell migration in human breast cancer as well as breast cancer cell lines. Therefore, our data establish that suppression of LSD1-mediated RORα2 transcriptional activity may be potent therapeutic strategy to attenuate tumor cell migration in human breast cancer.
Growth of Epitaxial ZnSnxGe1−xN2 Alloys by MBE
Authors: Shing Amanda M. , Tolstova Yulia , Lewis Nathan S. , Atwater Harry A. 
Published: September 2017

AbstractZnSnxGe1−xN2 alloys are chemically miscible semiconductor compounds with potential application as earth-abundant alternatives to InxGa1−xN. Preparation of ZnSnxGe1−xN2 thin-films by reactive RF sputter deposition yield low-mobility, nanocrystalline films. In contrast, the growth of ZnSnxGe1−xN2 films by molecular-beam epitaxy (MBE) on c-plane sapphire and GaN templates is described herein. Epitaxial films exhibited 3D growth on sapphire and 2D single-crystal quality on GaN, exhibiting substantial improvements in epitaxy and crystallinity relative to nanocrystalline sputtered films. Films on sapphire were n-type with electronic mobilities as high as 18 cm2 V−1 s−1, an order of magnitude greater than the 2 cm2 V−1 s−1 average mobility observed in this work for sputtered films. Mobility differences potentially arise from strain or surface effects originating from growth techniques, or from differences in film thicknesses. In general, MBE growth has provided desired improvements in electronic mobility, epitaxy, and crystal quality that provide encouragement for the continued study of ZnSnxGe1−xN2 alloys.
Carrier mobility and trap distribution dependent flashover characteristics of epoxy resin
Authors: Du Boxue , Du Qiang , Li Jin , Liang Hucheng 
Published: September 2017

Epoxy disc‐type spacer, as the major insulator of gas insulated transmission line, plays a significant role in the reliability and safety of the entire power grid. While surface charge accumulation on the spacer could induce flashover and accelerate degradation of the insulator, which threats the operation of high‐voltage DC transmission and grid. In this study, a corona discharging system was employed to charge the epoxy samples before the charge dissipation measured, and the surface flashover voltages of samples with different modification time under DC voltage were also measured, the results are obtained from the research. It is found that the carrier mobility and surface flashover voltage of samples are affected by modification time, and maximum value of both can be obtained when the sample is modified for 60 min. Under the combined voltages, the initial surface charge density and carrier mobility are affected by both pulse voltage and modification time. It is indicated that surface modification is an appropriate method which can significantly inhibit the surface charge accumulation, and improve the flashover characteristics of epoxy sample by increasing carrier mobility. The trap distribution characteristics suggested that the modification treatment and charging condition have a significant effect on the depth and density of trap.
Vitamin K–Dependent Protein S: Beyond the Protein C Pathway
Authors: Dahlbäck Björn 
Published: September 2017

AbstractProtein S is a vitamin K–dependent plasma glycoprotein circulating in plasma at a concentration of around 350 nM. Approximately 60% of protein S in human plasma is bound to the complement regulatory protein C4b-binding protein (C4BP) in a high-affinity, high-molecular-weight complex. Protein S in plasma has multiple anticoagulant properties and heterozygous protein S deficiency is associated with increased risk of venous thrombosis. Homozygous deficiency in man and mice is associated with severe thrombosis in fetal life, defects in the vascular system development, and not compatible with life. Protein S has additional functions beyond being an anticoagulant. It affects the complement regulatory properties of C4BP, and moreover, protein S interacts with tyrosine kinase receptors of the TAM family, which comprises Tyro3, Axl, and Mer. The TAM receptor interaction is important for the ability of protein S to stimulate phagocytosis of apoptotic cells. This review will discuss the multiple functions of protein S, describing its role as cofactor to activated protein C with a subsequent focus on the other functions of protein S.
Application of Tissue Expansion with Perforator Flaps for Reconstruction of Challenging Skin Lesions
Authors: Zhu Hainan , Gao Zhen , Tremp Mathias , Zan Tao , Li Qingfeng , Xie Feng , Gu Bin 
Published: September 2017

Background One set of perforators can supply its own perforasome as well as the adjacent perforasome. The process of tissue expansion can mimic the effect of surgical delay to include more perforasomes into the perforator flap. By combining the perforasome theory with the technique of tissue expansion, large and various expanded perforator flaps can be achieved.
Methods From July 2007 to July 2014, we performed eight different types of expanded perforator flaps in a total of 83 cases: 41 supraclavicular artery perforator flaps, 11 superficial cervical artery perforator flaps, 15 lateral thoracic perforator flaps, 6 internal mammary artery perforator flaps, 6 thoracoabdominal perforator flaps, 2 facial artery perforator flaps, 1 posterior interosseous perforator flap, and 1 ulnar collateral artery perforator flap. During the follow-up period, the survival rate, color, texture, and retraction of the flaps were assessed.
Results The dimensions of the flaps ranged from 8 × 6 to 25 × 25 cm. Minor flap necrosis occurred in 20.5% of the cases, and severe flap necrosis developed in 2.4% of the cases. The donor sites were closed primarily in all but three cases. During the follow-up period (average, 13 months; range, 8–18 months), no flap contracture was observed with a good color and texture match.
Conclusion By combining the concept of perforasome with the technique of tissue expansion, flaps with large dimensions and reliable blood supply can be achieved, allowing a more flexible design to reconstruct various and challenging skin lesions.
Quality of Life after Free Fibula Flap Reconstruction of Segmental Mandibular Defects
Authors: Nyberg Marcus , Karlsson Therese , Thórarinsson Andri , Kjeller Göran , Lidén Mattias , Fröjd Victoria , Löfstrand Jonas 
Published: September 2017

Background Free fibula flap (FFF) is considered gold standard in the reconstruction of mandibular defects. Despite the frequent use, patients' quality of life (QoL) after reconstruction has been sparsely investigated. This study aims to evaluate QoL and outcomes in patients who have undergone FFF reconstruction of segmental mandibular defects.
Methods A retrospective cohort study of consecutive patients (n = 73) operated at a single center during the years 2000 to 2014 was performed. Charts were reviewed and all living patients (n = 41) were invited to fill out three quality of life questionnaires (QLQ): SF-36, EORTC QLQ-C30, and QLQ-H&N35. Factors associated with poor outcome were derived from regression models and the results of the QLQs were compared with Swedish reference populations. Subgroup analysis was performed for two groups depending on reconstructive indication: cancer and osteoradionecrosis (ORN).
Results The response rate of the QLQs was 93%. General QoL did not differ from reference populations, but the study group had significantly larger proportions of poor functioning patients in three domains in EORTC QLQ-C30: global health status, role functioning, and social functioning. Patients also reported a high incidence of poor functioning/high symptom burden in EORTC QLQ-H&N35, with a significantly higher frequency in the ORN group compared with the cancer group for the domains “swallowing” and “social eating.” The overall flap success rate was 92% and complication rate was 48%. Previous surgery had a significant association with reoperation due to bleeding, and longer duration of surgery was significantly associated with local infection.
Conclusion When evaluated with validated QLQs, most patients experienced persistent functional loss in one or several domains, but still perceived a general QoL that is close to that of reference populations. Patients having ORN as the indication for surgery, as compared with cancer, reported a higher frequency of poor functioning patients in disease-specific QoL domains.
Porcelain Gallbladder: Often an Overlooked Entity
Authors: Iqbal Sohail , Ahmad Sarfraz , Saeed Usman , Al-dabbagh Mohammed 
Published: September 2017

Background Porcelain gallbladder (GB) is a rare but potentially premalignant condition with minimal symptoms. Accident and Emergency (A&E) departments often tend to investigate abdominal pain through plain radiographs, which are occasionally reported by radiologists, thereby leaving behind few uncommon conditions, such as porcelain gallbladder unreported.
Objectives We present three cases of porcelain GB in which initial diagnosis was not considered due to the presence of various other calcifications in the upper abdomen.
Methods In A&E, plain abdominal X-rays were routinely performed in all three patients to investigate nonspecific postprandial abdominal pain. Although GB calcification was easy to diagnose on plain films, it was initially overlooked to be a cause of the symptoms and later was diagnosed on abdominal CT scans, performed for further evaluation.
Results Abdominal X-rays revealed thin curvilinear calcification in the GB wall, partially calcified neck and body, and gall stones. CT scan confirmed porcelain GB in all three patients.
Conclusion Gallbladder mural calcification is a rare cause of nonspecific abdominal pain, which is often overlooked on plain abdominal X-rays causing missed diagnosis. The association of porcelain GB with adenocarcinoma entails special emphasis on timely diagnosis and prompt management.
Involvement of Nervous System in Kawasaki Disease
Authors: Giannopoulos Andreas , Gogou Maria 
Published: September 2017

AbstractThe aim of this study was to summarize the published reports about neurological manifestations of Kawasaki disease and underlying mechanisms. PubMed was used as the source for medical database. The prevalence of neurological complications is estimated to range from 1.1 to 3.7% and can include strokes, inflammation of central nervous system, dysfunction of cranial nerves, behavioral disorders as well as syndrome of inappropriate antidiuretic hormone secretion. Their incidence is usually associated with an increased risk for coronary artery aneurysms. In particular, the involvement of facial nerve seems to be a marker of disease severity. Although prognosis is generally remarkable, serious complications may arise in some cases. The early initiation of appropriate therapy prevents the appearance of neurological manifestations in children with Kawasaki disease.
Tratamiento artroscópico de las lesiones tipo 1B del fibrocartílago triangular
Authors: Reina C. , Gutiérrez M. , Luna A. , Martín F. , Sánchez-Heredero J. , Adarraga J. 
Published: September 2017

El complejo del fibrocartílago triangular (CFCT) desempeña un papel fundamental en la biomecánica de la muñeca. Actúa absorbiendo y transmitiendo cargas, y sirve como punto de pivote para la rotación del radio y del carpo alrededor del cúbito, por lo que funciona como centro de rotación del antebrazo. Además constituye el principal elemento estabilizador de la articulación radiocubital distal. Estudios histológicos han demostrado que la parte central del CFCT, también denominada disco articular, es avascular, mientras que su periferia está bien vascularizada, por lo que las lesiones de esta porción tienen mayor capacidad de regeneración. Las lesiones del CFCT constituyen una causa primaria de dolor en el lado cubital de la muñeca y de inestabilidad de la articulación radiocubital distal. Su tratamiento ha incluido una serie de medidas conservadoras así como un número variable de técnicas quirúrgicas, entre las que destacan en los últimos años el desbridamiento artroscópico en las lesiones centrales, y la reinserción artroscópica en las lesiones periféricas. Presentamos un estudio retrospectivo sobre los resultados del tratamiento artroscópico de las lesiones periféricas tipo 1B, realizado en 10 pacientes que fueron intervenidos quirúrgicamente en nuestro departamento entre los meses de febrero de 1999 y enero de 2002. Se realizó una reinserción artroscópica mediante técnica dentro-afuera y sutura en pull-out, obteniéndose resultados excelentes en 7 casos, buenos en 2 y malos en 1.The triangular fibrocartilage complex (TFCC) plays an important role in the biomechanics of the wrist. It acts by absorbing and transmitting loads, and serves as a pivot point for the rotation of the radiocarpal unit around the ulnar axis, and so it works as a centre of rotation for the forearm. It is also the main stabilising element of the distal radioulnar joint. Histological studies have shown that the central part of the TFCC, also known as the articular disc, is avascular, while its periphery is well vascularised, and so lesions in this section have a greater regeneration ability. TFCC lesions are a primary cause of pain in the ulnar side of the wrist and instability of the distal radioulnar joint. Treatment for this has included a series of conservative measures as well as a variable number of surgical techniques, particularly in recent years arthroscopic debridement in central lesions and athroscopic reinsertion in peripheral lesions. We present a retrospective study of the results of arthroscopic treatment of type 1B lesions, carried out on 10 patients who were operated on in our department between February 1999 and January 2002. Arthroscopic reinsertion was carried out using the internal-external and pull-out suture technique, with excellent results being obtained in 7 cases, good results in 2, and an unfavourable result in 1 case.
Tratamiento del quiste óseo aneurismático de los metacarpianos con injerto autólogo no vascularizado de peroné. A propósito de dos casos en niños
Authors: Vaquero-Cervino E. , Caeiro-Rey J. R. , García-Durán C. , Abril-Martín J. C. 
Published: September 2017

El quiste óseo aneurismático es una lesión tumoral benigna poco frecuente y que raras veces afecta a los huesos de la mano.Se presentan dos casos en niños, de afectación de los metacarpianos, que fueron tratados mediante resección de la lesión en bloque del metacarpiano, y reconstrucción con autoinjerto libre de peroné. Se obtuvo un buen resultado funcional sin recidiva a los seis y dos años respectivamente. No hubo morbilidad reseñable en la zona donante.
Artroplastia de resecciónsuspensión mediante el tendón flexor carpi radialis en cirugía de la articulación trapecio-metacarpiana
Authors: Blanco L. , Viñuela G. , Suárez M. , Gava R. , Vaquero D. 
Published: September 2017

Objetivos: Analizamos los resultados clínicos, radiológicos y funcionales mediante un estudio retrospectivo del tratamiento de la artrosis trapeciometacarpiana con técnica de artroplástia de resección-suspensión
Material y Métodos: Hemos revisado una serie de 36 artroplastias de interposición tendinosa utilizando el tendón del flexor carpi radialis intervenidas en nuestro servicio para el tratamiento de la artrosis trapecio-metacarpiana dolorosa e inestable. En 2 pacientes la intervención fue bilateral. Hubo un predominio de mujeres (82%). La media de edad fue de 62 años entre: 50-75. El seguimiento postoperatorio medio fue de 36 meses. Se evaluaron la presencia de dolor, la realización de actividades cotidianas, la movilidad y los resultados radiológicos tanto en el preoperatorio como después de la intervención.
Resultados y Conclusiones: La media de movimiento articular del pulgar aumentó, así como la fuerza de pinza y el ángulo interdigital. El resultado subjetivo fue bueno en el 97% de los casos. Consideramos que esta intervención es una opción valida en el tratamiento de la artrosis trapecio-metacarpiana dolorosa y con pérdida funcional.