bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of coping strategies on subsequent well‐being in older patients with cancer: A comparison with 2 control groups
Authors: Baitar Abdelbari , Buntinx Frank , De Burghgraeve Tine , Deckx Laura , Schrijvers Dirk , Wildiers Hans , van den Akker Marjan 
Published: November 2017

AbstractObjectiveTo evaluate dispositional coping strategies as predictors for changes in well‐being after 1 year in older patients with cancer (OCP) and 2 control groups.MethodsOCP were compared with 2 control groups: middle‐aged patients with cancer (MCP) (aging effect) and older patients without cancer (ONC) (cancer effect). Patients were interviewed shortly after a cancer diagnosis and 1 year later. Dispositional coping was measured with the Short Utrecht Coping List. For well‐being, we considered psychological well‐being (depression, loneliness, distress) and physical health (fatigue, ADL, IADL). Logistic regression analyses were performed to study baseline coping as predictor for subsequent well‐being while controlling for important baseline covariates.ResultsA total of 1245 patients were included in the analysis at baseline: 263 OCP, 590 ONC, and 392 MCP. Overall, active tackling was employed most often. With the exception of palliative reacting, OCP utilized each coping strategy less frequently than MCP. At 1‐year follow‐up, 833 patients (66.9%) were interviewed. Active coping strategies (active tackling and seeking social support) predicted subsequent well‐being only in MCP. Avoidance coping strategies did not predict well‐being in any of the patient groups. Palliative reacting predicted distress in OCP; depression and dependency for ADL in MCP.ConclusionsCoping strategies influence subsequent well‐being in patients with cancer, but the impact is different in the age groups. Palliative reacting was the only coping strategy that predicted well‐being (ie, distress) in OCP and is therefore, especially in this population, a target for coping skill interventions.
Unraveling the Mechanistic Complexity of the Glomerulocystic Phenotype in Dicer Conditional KO Mice by 2D Gel Electrophoresis Coupled Mass Spectrometry
Authors: Fiumara Claudia Vincenza , Scumaci Domenica , Iervolino Anna , Perri Angela Mena , Concolino Antonio , Tammè Laura , Petrillo Federica , Capasso Giovambattista , Cuda Giovanni 
Published: November 2017

PurposeDicer, an RNase III type endonuclease, is a key enzyme involved in miRNA biogenesis. It has been shown that this enzyme is essential for several aspects of postnatal kidney functions and homeostasis. In this study, we have examined conditional knockout (cKO) mice for Dicer in Pax8 (Paired‐box gene 8) expressing cells to investigate the kidney protein profile. This specific model develops a glomerulocystic phenotype coupled with urinary concentration impairment, proteinuria, and severe renal failure.Experimental designProteomic analysis was performed on kidney tissue extracts from cKO and control (Ctr) mice by 2D Gel Electrophoresis coupled with mass spectrometry.ResultsThe analysis highlighted 120 protein spots differentially expressed in Dicer cKO tissue compared with control; some of these proteins were validated by Western blotting. Ingenuity Pathway Analysis led to the identification of some interesting networks; among them, the one having ERK as a central hub may explain, through the modulation of the expression of a number of identified protein targets, the metabolic and structural alterations occurring during kidney cyst development in Dicer cKO mouse model.Conclusions and clinical relevanceOur results contribute to gain new insights into molecular mechanisms through which Dicer endonuclease controls kidney development and physiological functions.
Protein structure modeling and refinement by global optimization in CASP12
Authors: Hong Seung Hwan , Joung InSuk , Flores‐Canales Jose C. , Manavalan Balachandran , Cheng Qianyi , Heo Seungryong , Kim Jong Yun , Lee Sun Young , Nam Mikyung , Joo Keehyoung , Lee In‐Ho , Lee Sung Jong , Lee Jooyoung 
Published: November 2017

AbstractFor protein structure modeling in the CASP12 experiment, we have developed a new protocol based on our previous CASP11 approach. The global optimization method of conformational space annealing (CSA) was applied to 3 stages of modeling: multiple sequence‐structure alignment, three‐dimensional (3D) chain building, and side‐chain re‐modeling. For better template selection and model selection, we updated our model quality assessment (QA) method with the newly developed SVMQA (support vector machine for quality assessment). For 3D chain building, we updated our energy function by including restraints generated from predicted residue‐residue contacts. New energy terms for the predicted secondary structure and predicted solvent accessible surface area were also introduced. For difficult targets, we proposed a new method, LEEab, where the template term played a less significant role than it did in LEE, complemented by increased contributions from other terms such as the predicted contact term. For TBM (template‐based modeling) targets, LEE performed better than LEEab, but for FM targets, LEEab was better. For model refinement, we modified our CASP11 molecular dynamics (MD) based protocol by using explicit solvents and tuning down restraint weights. Refinement results from MD simulations that used a new augmented statistical energy term in the force field were quite promising. Finally, when using inaccurate information (such as the predicted contacts), it was important to use the Lorentzian function for which the maximal penalty arising from wrong information is always bounded.
Crystal structure of the Legionella effector Lem22
Authors: Kozlov Guennadi , Wong Kathy , Gehring Kalle 
Published: November 2017

AbstractLegionella pneumophila is a pathogen causing severe pneumonia in humans called Legionnaires’ disease. Lem22 is a previously uncharacterized effector protein conserved in multiple Legionella strains. Here, we report the crystal structure of Lem22 from the Philadelphia strain, also known as lpg2328, at 1.40 Å resolution. The structure shows an up‐and‐down three‐helical bundle with a significant structural similarity to a number of protein‐binding domains involved in apoptosis and membrane trafficking. Sequence conservation identifies a putative functional site on the interface of helices 2 and 3. The structure is an important step toward a functional characterization of Lem22.
Data visualizations to detect systematic errors in laboratory assay results
Authors: Lötsch Jörn 
Published: November 2017

AbstractThe measurement of concentrations of drugs and endogenous substances is widely used in basic and clinical pharmacology research and service tasks. Using data science‐derived visualizations of laboratory data, it is demonstrated on a real‐life example that basic statistical exploration of laboratory assay results or advised standard visual methods of data inspection may fall short in detecting systematic laboratory errors. For example, data pathologies such as generating always the same value in all probes of a particular assay run may pass undetected when using standard methods of data quality check. It is shown that the use of different data visualizations that emphasize different views of the data may enhance the detection of systematic laboratory errors. A dotplot of single data in the order of assay is proposed that provides an overview on the data range, outliers and a particular type of systematic errors where similar values are wrongly measured in all probes.
Using wind velocity estimated from a reanalysis to minimize the variability of aggregated wind farm production over Europe
Authors: Tejeda César , Gallardo Clemente , Domínguez Marta , Gaertner Miguel Ángel , Gutierrez Claudia , de Castro Manuel 
Published: November 2017

AbstractIn this work we use the mean‐variance portfolio optimization, using as input the power derived from the wind and density results of meteorological model simulations (ERA‐Interim reanalysis), to minimize the variability of the wind power produced in a large region. The methodology involves selecting the placement of the wind farms on a high spatial resolution grid. We used the EU‐28 region to check the method and perform sensitivity tests. We studied the influence of the ratio between the total installed power of the whole domain (Pt) and the maximum power that can be installed per cell (Pmi) on the variability of wind power yield. The results show that the reliability of the electrical system improves when Pmi grows and worsens when Pt grows. A quadratic fit relates the variability of the system and the aforementioned ratio. The optimization procedure tends to select groups of terrain cells where wind farms should be installed. These groups grow when more energy production is demanded of the system, but they roughly maintain their location. There is some evidence that in a larger region greater system reliability could be achieved. Most of the selected cells have either a high or a low capacity factor and those with the latter are crucial in enhancing system reliability.
Road mitigation is a demographic filter for grizzly bears
Authors: Ford Adam T. , Barrueto Mirjam , Clevenger Anthony P. 
Published: November 2017

ABSTRACTCrossing structures (i.e., underpasses and overpasses) are becoming a widespread approach to promote movement of wildlife across roads. Studies have shown that species select for different crossing structure designs, yet little is known about intraspecific variation (i.e., differences among demographic classes) in crossing structure preference. Using data on grizzly bear (Ursus arctos) movement in Banff National Park (AB, Canada), we focused on selection by family groups (adult females travelling with young) and singleton (adult male or female) bears for 5 crossing structure designs distributed among 44 sites. Using data from the world's longest running monitoring program (1997–2014) on wildlife crossing structure use, we created an economic model to estimate demographic‐specific cost‐effectiveness for each crossing structure design. We found that all grizzly bears selected larger and more open structures (overpasses and open‐span bridges). Use of these structures has generally increased with time at a rate that exceeds estimates of population growth. Family groups were more selective than singletons and strongly selected overpasses. In spite of singletons’ selection for overpasses and open‐span bridges, box culverts were comparable in cost‐effectiveness. Our results suggest that structure designs targeting the selection of grizzly bear family groups are effective at restoring population connectivity, but a systematic approach to designing highway mitigation also would consider the role of lesser used structures in reducing intraspecific predation and multispecies connectivity targets. © 2017 The Wildlife Society.
Complex Chern-Simons from M5-branes on the squashed three-sphere
Authors: Córdova Clay , Jafferis Daniel L. 
Published: November 2017

AbstractWe derive an equivalence between the (2,0) superconformal M5-brane field theory dimensionally reduced on a squashed three-sphere, and Chern-Simons theory with complex gauge group. In the reduction, the massless fermions obtain an action which is second order in derivatives and are reinterpreted as ghosts for gauge fixing the emergent non-compact gauge symmetry. A squashing parameter in the geometry controls the imaginary part of the complex Chern-Simons level.
A Novel Technique of Paravertebral Thoracic and Preperitoneal Analgesia Enhances Early Recovery After Oesophagectomy
Authors: Phillips Stephanie , Dedic‐Hagan Jasmina , Baxter d’Arcy Ferris , Van der Wall H. , Falk G. L. 
Published: November 2017

AbstractBackgroundExcellent analgesia following oesophagectomy facilitates patient comfort, early extubation, physiotherapy and mobilisation, reduces post‐operative complications and should enhance recovery. Thoracic epidural analgesia (TEA), the gold standard analgesic regimen for this procedure, is often associated with systemic hypotension treated with inotropes or fluid. This may compromise enhanced recovery and be complicated by anastomotic ischaemia or tissue oedema.MethodsWe report a novel analgesic regimen to reduce post‐operative inotrope usage. Infusion of ropivicaine via bilateral preperitoneal and right paravertebral catheters was used. Patient‐controlled epidural pethidine provided rescue analgesia (WC) (n = 21). A retrospective audit of inotrope requirement, mean pain scores, episodes of respiratory depression and excessive sedation, need for reintubation, reoperation in the first 5 post‐operative days, time to mobilisation, time in intensive care, time in hospital and 30‐day mortality were measured. These results were compared with those of an earlier patient group who received a thoracic epidural infusion of low‐dose local anaesthetic and fentanyl (TEA) (n = 21).ResultsInotrope use was reduced by 29% in the WC group (p = 0.03) and the mean intensive care stay reduced by 2.4 days (p = 0.03), as was reintubation rate (p = 0.01) and early mobilisation (p = 0.03). The pain score was comparable in both groups, and there was no difference in the other outcomes examined.ConclusionThe data demonstrated that it was possible to provide excellent post‐oesophagectomy analgesia equivalent to thoracic epidural infusions of local anaesthetic with reduction in inotrope requirements, intensive care stay, more rapid mobilisation, facilitating enhanced recovery.
Cognitive Disparities: The Impact of the Great Depression and Cumulative Inequality on Later-Life Cognitive Function
Authors: Hale Jo Mhairi 
Published: November 2017

Abstract
Population aging has driven a spate of recent research on later-life cognitive function. Greater longevity increases the lifetime risk of memory diseases that compromise the cognitive abilities vital to well-being. Alzheimer’s disease, thought to be the most common underlying pathology for elders’ cognitive dysfunction (Willis and Hakim 2013), is already the sixth leading cause of death in the United States (Alzheimer’s Association 2016). Understanding social determinants of pathological cognitive decline is key to crafting interventions, but evidence is inconclusive for how social factors interact over the life course to affect cognitive function. I study whether early-life exposure to the Great Depression is directly associated with later-life cognitive function, influences risky behaviors over the life course, and/or accumulates with other life-course disadvantages. Using growth curve models to analyze the Health and Retirement Study, I find that early-life exposure to the Great Depression is associated with fluid cognition, controlling for intervening factors—evidence for a critical period model. I find little support for a social trajectory model. Disadvantage accumulates over the life course to predict worse cognitive function, providing strong evidence for a cumulative inequality model.
Gender and the Stability of Same-Sex and Different-Sex Relationships Among Young Adults
Authors: Joyner Kara , Manning Wendy , Bogle Ryan 
Published: November 2017

Abstract
Most research on the stability of adult relationships has focused on coresidential (cohabiting or married) unions and estimates rates of dissolution for the period of coresidence. Studies examining how the stability of coresidential unions differs by sex composition have typically found that same-sex female couples have higher rates of dissolution than same-sex male couples and different-sex couples. We argue that the more elevated rates of dissolution for same-sex female couples are a by-product of the focus on coresidential unions. We use data from the National Longitudinal Study of Adolescent to Adult Health to compare rates of dissolution based on the total duration of romantic and sexual relationships for same-sex male couples, same-sex female couples, and different-sex couples. Results from hazard models that track the stability of young adult relationships from the time they are formed demonstrate that male couples have substantially higher dissolution rates than female couples and different-sex couples. Results based on models restricted to the period of coresidence corroborate the counterintuitive finding from earlier studies that female couples have the highest rates of dissolving coresidential unions. This study underlines the importance of comparisons between these couple types for a better understanding of the role that institutions and gender play in the stability of contemporary relationships.
Maternal depressive symptoms and adolescent academic attainment: Testing pathways via parenting and self‐control
Authors: Ng‐Knight Terry , Shelton Katherine H. , Frederickson Norah , McManus I.C. , Rice Frances 
Published: November 2017

ABSTRACTMaternal depression is associated with reduced academic attainment in children, however, it is not clear how this association comes about. Depressive symptoms are associated with impairment in social roles including parenting. Children's self‐control is an important contributor to academic attainment and is influenced by parenting. We therefore hypothesised that impaired parenting and children's self‐control may mediate links between maternal depression and children's academic attainment. Data were from a brief longitudinal study (3 waves) of UK children aged 11–12 years and their mothers. Higher maternal depressive symptoms at baseline were associated with lower academic attainment in children assessed one year later. There was evidence to support an indirect effect of maternal depressive symptoms on children's academic attainment through the mother‐child and the father‐child relationship which, in turn, reduced children's self‐control. These influences were independent of socio‐economic deprivation. A direct effect of maternal depression on children's academic attainment was also observed.
“So that's the way it is for me — always being left out.” Acquired Pragmatic Language Impairment and Social Functioning following Traumatic Brain Injury
Authors: Douglas Jacinta M. 
Published: November 2017

Our ability to interact appropriately in everyday interpersonal situations is fundamental to successful social integration. Impaired pragmatic competence correlates significantly and substantially with indices of social function across several domains for adults with acquired neurological disorders. In particular, evidence supports the negative impact of pragmatic impairments on the development and maintenance of relationships and community integration more generally.Pragmatic language competence sits in a complex, multifactorial space characterised by interacting associations with cognitive and psychological functions and social and environmental parameters. This complexity is evident in much of the research seeking to unravel the nature and magnitude of interactions between pragmatic language competence and social outcomes in adults with acquired neurological disorders.Over recent years our understanding of the impact of pragmatic impairments on social outcome has benefited substantially from inclusion of the insider's perspective in our research evidence base. Indeed, a methodological inclusion of constructivist paradigms has enabled the development of a rich understanding of the devastating social impact of impaired pragmatic competence.The aim of this paper is to review pragmatic language impairment in the context of traumatic brain injury (TBI) and detail its impact on social functioning from the perspectives of people with TBI and their intimate partners/spouses and friends. With these perspectives as background, the paper concludes with consideration of therapeutic developments and a brief look at a novel intervention designed to reduce the negative impact of pragmatic deficits and improve functional language use following TBI.
Botulinum Toxin Type A Injections as Monotherapy for Upper Limb Essential Tremor Using Kinematics
Authors: Samotus Olivia , Kumar Niraj , Rizek Philippe , Jog Mandar 
Published: November 2017

AbstractBackground:There is a significant need for a targeted therapy for essential tremor (ET), as medications have not been developed specifically for ET, and the ones prescribed are often not well-tolerated, so that many patients remain untreated. Recent work has shown that, unlike previous experience, kinematically guided individualized botulinum toxin type A (BoNT-A) injections provide benefit along with minimal weakness. Ours is the first long-term (96-week) safety and efficacy study of BoNT-A as monotherapy for ET using kinematically driven injection parameters.Methods:Ten ET patients were administered six serial BoNT-A treatments every 16 weeks and were assessed at 6 weeks following treatment. During each study visit, the Fahn–Tolosa–Marin (FTM) scale, the Unified Parkinson’s Disease Rating Scale, and the Quality of Life for Essential Tremor Questionnaire (QUEST) were administered along with kinematic assessment of the treated limb. Participants performed scripted tasks with motion sensors placed over each arm joint. Dosing patterns were determined using the movement disorder neurologist’s interpretation of muscles contributing to the kinematically analyzed upper limb tremor biomechanics.Results:There was a 33.8% (p<0.05) functional improvement (FTM part C) and a 39.8% (p<0.0005) improvement in QUEST score at week 96 compared to pretreatment scores at week 0. Although there was a 44.6% (p<0.0005) non-dose-dependent reduction in maximal grip strength, only 2 participants complained of mild weakness. Following the fourth serial treatment, mean action tremor score was reduced by 62.9% (p=0.001) in the treated and by 44.4% (p=0.03) in the untreated arm at week 96 compared to week 48.Conclusions:Individualized BoNT-A dosing patterns to each individual’s tremor biomechanics provided an effective monotherapy for ET as function improved without functionally limiting muscle weakness.
A Self-Regulation Model of Zhong Yong Thinking and Employee Adaptive Performance
Authors: Pan Wen , Sun Li-Yun 
Published: November 2017

ABSTRACTIndigenous Chinese management research has attracted much academic attention in recent years. This study examines the mechanism through which Zhong Yong thinking influences employee adaptive performance from a self-regulation perspective. Using two-wave data of 361 subordinates in 62 teams from Chinese firms, job complexity was found to moderate the direct effect of Zhong Yong thinking on cognitive adaptability and emotional control, and the indirect effect on adaptive performance (via cognitive adaptability and emotional control). The direct and indirect effects of Zhong Yong thinking were found to be stronger with a higher level of job complexity. The study explores an important Chinese indigenous construct and its association with adaptive performance, and adds value to the indigenous management literature.