bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of repetitive transcranial magnetic stimulation on the Hamilton Depression Rating Scale-17 criterion in patients with major depressive disorder without psychotic features: a systematic review and meta-analysis of intervention studies
Authors: Hassanzadeh Elham , Moradi Ghobad , Arasteh Modabber , Moradi Yousef 
Published: September 2024

Abstract
Aim
In line with the publication of clinical information related to the therapeutic process of repetitive transcranial magnetic stimulation (rTMS) and the updating of relevant treatment guidelines, the present meta-analysis study was designed and conducted to determine the effect of repetitive transcranial magnetic stimulation (rTMS) on the Hamilton Depression Rating Scale-17 (HDRS-17) criterion in patients with major depressive disorder (MDD) without psychotic features.

Methods
In this study, a systematic search was conducted in electronic databases such as PubMed [Medline], Scopus, Web of Science, Embase, Ovid, Cochrane Library, and ClinicalTrials. gov using relevant keywords. The search period in this study was from January 2000 to January 2022, which was updated until May 2023. Randomized controlled trials (RCTs) that determined the effect of repetitive transcranial magnetic stimulation (rTMS) on the Hamilton Depression Rating Scale-17 (HDRS-17) criterion in patients with major depressive disorder (MDD) without psychotic features were included in the analysis. The quality of the included RCTs was assessed using the Cochrane Risk of Bias checklist. Statistical analyses were performed using STATA (Version 16) and RevMan (Version 5).

Results
Following the combination of results from 16 clinical trial studies in the present meta-analysis, it was found that the mean Hamilton Depression Rating Scale-17 (HDRS-17) in patients with major depressive disorder (MDD) decreases by an average of 1.46 units (SMD: -1.46; % 95 CI: -1.65, -1.27, I square: 45.74%; P heterogeneity: 0.56). Subgroup analysis results indicated that the standardized mean difference of Hamilton Depression Rating Scale-17 (HDRS-17) varied based on the number of treatment sessions: patients receiving 10 or fewer repetitive transcranial magnetic stimulation (rTMS) sessions showed a mean Hamilton Depression Rating Scale-17 (HDRS-17) reduction of 2.60 units (SMD: -2.60; % 95 CI: -2.86, -2.33, I square: 55.12%; P heterogeneity: 0.55), while those receiving 11 to 20 sessions showed a mean Hamilton Depression Rating Scale-17 (HDRS-17) reduction of 0.28 units (SMD: -0.28; % 95 CI: -0.65, -0.09, I square: 39.91%; P heterogeneity: 0.89).

Conclusion
In conclusion, our meta-analysis demonstrates the efficacy of repetitive transcranial magnetic stimulation (rTMS) in reducing depressive symptoms in major depressive disorder (MDD) patients. The complex results of subgroup analysis revealed insight on the possible benefits of a more focused strategy with fewer sessions, as well as the impact of treatment session frequency. These findings add to our understanding of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic intervention for the treatment of major depressive illnesses.
Evaluating the effectiveness and adverse effects of oral versus transdermal estradiol for endometrial preparation in frozen-thawed embryo transfer: a randomized controlled trial
Authors: Tran Thuy Thi-Thanh , Tran Huy Phuong , Ly Loc Thai , Hoang Tuyet Thi-Diem , Huynh Trang Nguyen-Khanh , Dang Son Truong 
Published: September 2024

Abstract
Background
Endometrial preparation significantly influences the success of embryo transfer procedures. Although both oral and transdermal estradiol are common methods for endometrial priming, their efficacy and potential side effects remain uncertain. This randomized controlled trial aims to compare the effectiveness of oral and transdermal estradiol in endometrial preparation, while also evaluating their respective side effects in patients undergoing assisted reproduction treatments.

Method
This randomized clinical trial (ISRCTN15301227) was conducted at Hung Vuong Hospital between July 2020 and March 2022. Among 550 eligible patients undergoing frozen embryo transfer cycles, we included 380 patients for the study. The study protocol and all materials received approval from the Ethics Committee of Hung Vuong Hospital (1315/CN-HĐĐĐ). Participants were randomly assigned to one of two groups: Group A (n =190) received oral estradiol at an initial dose of 4 mg per day for 7 days, with the dose increased according to clinical response. Group B (n =190) received transdermal estradiol at an initial dose of 2 measures of 2.5 g estradiol gel per day for 7 days, with the dose similarly increased according to clinical response. Treatment in both groups began on days 2–3 of the menstrual cycle, with the maximum duration of estradiol administration being 27 days. We compared estradiol levels on the day of progesterone administration, duration of treatment, total estradiol dose, endometrial thickness, pregnancy outcomes, and any observed side effects between the two groups.

Results
Group A exhibited significantly higher estradiol levels on the day of progesterone administration compared to Group B (270.5 pg/ml versus 186.5 pg/ml, p < 0.001). However, the comparison revealed no significant difference in endometrial thickness between the two groups (10.5 mm versus 10.6 mm, p = 0.85). Furthermore, pregnancy rates including positive human chorionic gonadotropin, clinical pregnancy, ongoing pregnancy, live birth, and pregnancy failure were also found to be similar between the two groups. Notably, a greater proportion of patients in Group A experienced mild side effects compared to those in Group B (20.3% versus 10.1%, respectively; n =37 versus n =18), and this discrepancy was found to be statistically significant (p = 0.007).

Conclusion
Transdermal estradiol offers comparable endometrial thickness and pregnancy outcomes, along with improved patient compliance and fewer side effects compared to oral estradiol.
The prevalence of musculoskeletal pain among school students and its association with physical fitness in Guwahati urban society: a cross sectional study
Authors: Gogoi Pranjal , Bhattacharyya Nirmal Chandra , Saikia Kabul Chandra 
Published: September 2024

Abstract
Introduction and background
The musculoskeletal pain (MSK) develops at an early age and pains in adolescence dispose to subsequent pain episodes in adulthood. High physical fitness levels in childhood and adolescence are linked to favorable health outcomes.
This study has evaluated the prevalence of musculoskeletal pain among school students. Additionally, it examines the existing physical fitness of those children and explores potential associations between musculoskeletal pain and physical fitness.

Methods
A cross sectional study was conducted in the Guwahati urban area, a capital city of North East India, in different schools. The mean and standard deviation of age was 9.49 ± 2.53. Prevalence of MSK pain was determined by the Faces Pain Scale–Revised and pediatric Gait Arm Leg Spine (pGALS) assessment, whereas physical fitness was assessed by Fitnessgram test battery.

Statistical analysis
Paired “t” test and logistic regression analysis were used. The level of significance was set at 0.05 for all tests performed, and 95% confidence intervals (CIs) were used in all cases.

Results
The percentage of musculoskeletal pain is 38.28% where female school students have 40.33% and the male students have 36.52%. The odd ratio of 0.934 (CI = 0.916–0.972) was found between pain occurrence and aerobic capacity. The odd ratio of 0.72 (CI = 0.704–0.761) was found between the chances of pain onset and abdominal strength and endurance. The odd ratio of 0.859 (CI = 0.831–0.899) was found between pain occurrence and trunk extensor muscle strength and endurance.

Conclusion
The prevalence of the musculoskeletal pain in school students is found to be 38.28%. The incidence of musculoskeletal pain and the physical fitness of a child has a significant relationship, with children who have poor physical fitness being more likely to develop musculoskeletal pain.
Impact of storage conditions on the shelf life of aflatoxin biocontrol products containing atoxigenic isolates of
Aspergillus flavus
as active ingredient applied in various countries in Africa
Authors: Ortega-Beltran Alejandro , Aikore M. O. Samuel , Kaptoge Lawrence , Agbetiameh Daniel , Moral Juan , Bandyopadhyay Ranajit 
Published: September 2024

Abstract

Aflatoxin contamination significantly threatens food safety and security, particularly in tropical and sub-tropical regions where staple crops such as maize, groundnut, and sorghum become frequently affected. This contamination is primarily caused by the fungus
Aspergillus flavus
. The contamination causes adverse health effects, reduced income, and trade restrictions. In response to this challenge, various technologies have been developed to mitigate the impacts of aflatoxin. Among these, biocontrol products containing atoxigenic isolates of
A. flavus
as the active ingredient can effectively reduce aflatoxin levels both at pre- and post-harvest. A notable example of such products is Aflasafe, which contains four atoxigenic isolates native to specific target regions. These products have undergone rigorous testing, have received regulatory approval, and are commercially available in multiple African countries. However, their manufacturing processes have evolved, and comprehensive shelf life studies for current formulations are lacking. Evaluations of the spore production ability of atoxigenic
A. flavus
isolates in Aflasafe products over 4 years, under various storage conditions, revealed a significant linear decrease in sporulation with storage months (
P
< 0.001;
R

2

= 0.203), with no significant differences observed between treatments. However, this marginal decline (
P
= 0.398) is unlikely to be sufficient to prevent the effectiveness in limiting aflatoxin. In addition, storing the products for 2 weeks at 54 °C did not affect (
P
> 0.05) the ability of the coated fungi to produce spores compared to when the products were stored at 24 °C. The findings contribute valuable insights for manufacturers and users of atoxigenic-based aflatoxin biocontrol products, informing best practices for product storage and utilization to ensure prolonged effectivenes in aflatoxin mitigation efforts.
Ascending aortic aneurysm after acute aortic dissection in a case with systemic lupus erythematosus
Authors: Sasaki Hanae , Kowatari Ryosuke , Imamura Yuki , Goto Shintaro , Kurose Akira , Minakawa Masahito 
Published: September 2024

AbstractA 50-year-old woman with systemic lupus erythematosus and a history of aortic arch replacement surgery for Stanford type A aortic dissection experienced a reoccurrence of an ascending aortic aneurysm and coronary artery occlusion. Computed tomography revealed that the aneurysm was compressing the superior vena cava and right atrium. The patient underwent urgent surgery to repair the aneurysm. This case highlights that aortic aneurysms can reoccur even after total arch replacement in systemic lupus erythematosus patients.
Limiting Premenstrual Endometrial Hypoxia Inducible Factor 2 Alpha May Fine-Tune Endometrial Function at Menstruation
Authors: Martínez-Aguilar Rocío , Rowley Bethan M , Walker Catherine , Critchley Hilary O D , Carmeliet Peter , Maybin Jacqueline A 
Published: September 2024

Abstract

Context
Heavy menstrual bleeding (HMB) is common and debilitating, but the precise endometrial mechanisms causing increased menstrual blood loss (MBL) remain undefined. We have previously identified a role for hypoxia in endometrial repair following progesterone withdrawal.

Objective
As hypoxia inducible factor 2 alpha (HIF2A) is known to alter vascular function in other tissues, we hypothezised that endometrial HIF2A is involved in premenstrual optimization of endometrial function during the secretory phase to limit MBL.

Results
Women with objective HMB had higher endometrial HIF2A during the mid-secretory phase when compared to those with normal MBL (P = 0.0269). In a mouse model of simulated menses, genetic or pharmacological manipulation of HIF2A did not significantly affect endometrial breakdown/repair, volume of MBL or endometrial hypoxia. However, 88% of Hif2a heterozygote mice reached early-full repair by 24 hours vs only 65% of wild-type mice. Mean MBL was 0.39 μL (±0.67) in Hif2a heterozygote mice vs 0.98 μL (±0.79) in wild-type mice. Conversely, when we increased HIF2A before menstruation, 11% reached early repair by 8 hours vs 30% of vehicle-treated mice. Mean MBL was 2.61 μL (±1.10) in mice with HIF2A stabilization and 2.24 μL (±1.14) in vehicle-treated mice. These nonsignificant but consistent trends indicate that increased endometrial HIF2A may contribute to delayed endometrial repair and HMB.

Conclusions
Increased HIF2A in the secretory endometrium is unlikely to be sufficient to account for the phenotype of HMB, but limitation of HIF2 levels may optimize endometrial function at menstruation.
MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer
Authors: Andolfi Chiara , Bartolini Caterina , Morales Elisa , Gündoğdu Büşra , Puhr Martin , Guzman Juan , Wach Sven , Taubert Helge , Aigner Achim , Eder Iris E , Handle Florian , Culig Zoran 
Published: September 2024

Abstract
Prostate cancer progression is driven by androgen receptor (AR) activity, which is a target for therapeutic approaches. Enzalutamide is an AR inhibitor that prolongs the survival of patients with advanced prostate cancer. However, resistance mechanisms arise and impair its efficacy. One of these mechanisms is the expression of AR-V7, a constitutively active AR splice variant. The Mediator complex is a multisubunit protein that modulates gene expression on a genome-wide scale. MED12 and cyclin-dependent kinase (CDK)8, or its paralog CDK19, are components of the kinase module that regulates the proliferation of prostate cancer cells. In this study, we investigated how MED12 and CDK8/19 influence cancer-driven processes in prostate cancer cell lines, focusing on AR activity and the enzalutamide response. We inhibited MED12 expression and CDK8/19 activity in LNCaP (AR+, enzalutamide-sensitive), 22Rv1 (AR-V7+, enzalutamide-resistant), and PC3 (AR−, enzalutamide-insensitive) cells. Both MED12 and CDK8/19 inhibition reduced cell proliferation in all cell lines, and MED12 inhibition reduced proliferation in the respective 3D spheroids. MED12 knockdown significantly inhibited c-Myc protein expression and signaling pathways. In 22Rv1 cells, it consistently inhibited the AR response, prostate-specific antigen (PSA) secretion, AR target genes, and AR-V7 expression. Combined with enzalutamide, MED12 inhibition additively decreased the AR activity in both LNCaP and 22Rv1 cells. CDK8/19 inhibition significantly decreased PSA secretion in LNCaP and 22Rv1 cells and, when combined with enzalutamide, additively reduced proliferation in 22Rv1 cells. Our study revealed that MED12 and CDK8/19 regulate AR activity and that their inhibition may modulate response to enzalutamide in prostate cancer.
Characterization of FGF21 Sites of Production and Signaling in Mice
Authors: Sullivan Andrew I , Jensen-Cody Sharon O , Claflin Kristin E , Vorhies Kai E , Flippo Kyle H , Potthoff Matthew J 
Published: September 2024

Abstract
Fibroblast growth factor (FGF) 21 is an endocrine hormone that signals to multiple tissues to regulate metabolism. FGF21 and another endocrine FGF, FGF15/19, signal to target tissues by binding to the co-receptor β-klotho (KLB), which then facilitates the interaction of these different FGFs with their preferred FGF receptor. KLB is expressed in multiple metabolic tissues, but the specific cell types and spatial distribution of these cells are not known. Furthermore, while circulating FGF21 is primarily produced by the liver, recent publications have indicated that brain-derived FGF21 impacts memory and learning. Here we use reporter mice to comprehensively assess KLB and FGF21 expression throughout the body. These data provide an important resource for guiding future studies to identify important peripheral and central targets of FGFs and to determine the significance of nonhepatic FGF21 production.
Deletion of Nuclear Progesterone Receptors From Kisspeptin Cells Does Not Impair Negative Feedback in Female Mice
Authors: Dillon Kendra M , Lohr Dayanara B , Novak Alyssa G , Petriv Anna-Maria V , Neifert Nicole T , Moore Aleisha M 
Published: September 2024

Abstract
Reproductive function in mammals depends on the ability of progesterone (P4) to suppress pulsatile gonadotrophin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in a homeostatic-negative feedback loop. Previous research identified that cells upstream from GnRH neurons expressing the nuclear progesterone receptor (PGR) are required for P4-negative feedback. However, the identity of these cells and the mechanism by which they reduce GnRH/LH pulsatile secretion is unknown. We aimed to address the hypothesis that PGR expressed by a neural population in the arcuate nucleus recently identified as the GnRH pulse generator, cells expressing kisspeptin, neurokinin B, and dynorphin (KNDy cells), mediate P4-negative feedback. To achieve this, we used female mice with the PGR gene conditionally deleted from kisspeptin cells (KPRKO mice) and observed a substantial decrease in the percentage of KNDy neurons coexpressing PGR messenger RNA (mRNA) (11% in KPRKO mice vs 86% in wild-type [WT] mice). However, KPRKO mice did not display changes in the frequency or amplitude of LH pulses in diestrus or estrus, nor in the ability of exogenous P4 to blunt a postcastration increase in LH. Further, mRNA expression of arcuate kisspeptin and dynorphin, which are excitatory and inhibitory to GnRH secretion, respectively, remained unaltered in KPRKO mice compared to WT controls. Together, these findings show that the near-complete loss of PGR signaling from KNDy cells does not affect negative feedback regulation of GnRH pulse generation in mice, suggesting that feedback through this receptor can occur via a small number of KNDy cells or a yet unidentified cell population.
Immersive Photorealistic Three-Dimensional Neurosurgical Anatomy of the Cerebral Arteries: A Photogrammetry-Based Anatomic Study
Authors: Spiriev Toma , Körner Kay M. , Steuwe Andrea , Wolf-Vollenbröker Michael , Trandzhiev Martin , Nakov Vladimir , Cornelius Jan Frederick 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Neurosurgeons need a profound knowledge of the surgical anatomy of the cerebral arteries to safely treat patients. This is a challenge because of numerous branches, segments, and tortuosity of the main blood vessels that supply the brain. The objective of this study was to create high-quality three-dimensional (3D) anatomic photorealistic models based on dissections of the brain arterial anatomy and to incorporate this data into a virtual reality (VR) environment.

METHODS:
Two formaldehyde-fixed heads were used. The vessels were injected with radiopaque material and colored silicone and latex. Before the dissections, the specimens were computed tomography scanned. Stratigraphical anatomic dissection of the neck and brain was performed to present the relevant vascular anatomy. A simplified surface scanning method using a mobile phone-based photogrammetry application was used, and the data were incorporated into a VR 3D modeling software for post-processing and presentation.

RESULTS:
Fifteen detailed layered photorealistic and two computed tomography angiography-based 3D models were generated. The models allow manipulation in VR environment with sufficient photographic detail to present the structures of interest. Topographical relevant anatomic structures and landmarks were annotated and uploaded for web-viewing and in VR. Despite that the VR application is a dedicated 3D modeling platform, it provided all necessary tools to be suitable for self-VR study and multiplayer scenarios with several participants in one immersive environment.

CONCLUSION:
Cerebral vascular anatomy presented with photogrammetry surface scanning method allows sufficient detail to present individual vessel's course and even small perforating arteries in photorealistic 3D models. These features, including VR visualization, provide new teaching prospects. The whole study was done with simplified algorithms and free or open-source software platforms allowing creation of 3D databases especially useful in cases with limited body donor-based dissection training availability.
Temporal Miscoupling: The Challenges and Consequences of Enacting a Practice in Decline
Authors: Casillas Samantha Ortiz , Huising Ruthanne 
Published: September 2024

A practice firmly entrenched in one period can experience decline or even deinstitutionalization in another. However, at the organization level, practice abandonment can be a slow process. Organizations may continue to use a practice that is in decline or out of date, coupling asynchronously with a prior institutional environment. In this paper we develop the concept of temporal miscoupling and examine the challenges of performing a practice under this condition. Drawing on a field study of a labor strike in Canada, we examine the difficulties of inhabiting the practice of striking—picketing a workplace—with eroding political, legal, and cultural support; declining familiarity with the practice; and fading narratives to motivate and justify the practice. We show how strikers developed extemporaneous resources that gave local meaning and form to the practice. These improvised resources supported the practice but distorted historical meanings and performances. Our study expands the analytical repertoire of inhabited institutionalism by problematizing the temporal lag between institutional conditions and organizational practices for the on-the-ground enactment of practices. The extemporaneous resources generated in the context of temporal miscoupling threaten future enactments, indicating an important role for practice enactment in processes of decline and revitalization. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2021.16026 .
Optical design and coating optimization of the Wolter-I X-ray telescope
Authors: Geng Yujia , Yang Yanji , Zheng Renzhou , Li Yue , Yan Yongqing , Yang Bingqing , Zhou Qingyong , Qiang Pengfei , Sheng Lizhi 
Published: September 2024

The optical design of the nested paraboloid and hyperboloid Wolter I
X-ray telescope of the eXTP satellite in the 1–8 keV band was
systematically studied. The recursive relationship of nested
structures is derived, and an analysis is conducted on the influence
of initial parameters on performance. Considering the requirements of
X-ray astronomical observation in China, we propose the initial
structure of the model and design seven groups of Au/C/Ni non-periodic
dual-layer coatings between the innermost and outermost layers of the
mirror. The effective area, half-power diameter, and stray light were
calculated in the simulation. The results show that the effective area
can reach 1000cm2 at 2 keV, the effective area
can reach 890cm2 at 6 keV without hub
obscuration, the half-power diameter is 10 arcsec, and the
proportion of stray light is 4.2%.