bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit
Authors: Kozuka Takashi , Chaya Taro , Tamalu Fuminobu , Shimada Mariko , Fujimaki-Aoba Kayo , Kuwahara Ryusuke , Watanabe Shu-Ichi , Furukawa Takahisa 
Published: September 2017

Neurotransmission plays an essential role in neural circuit formation in the central nervous system (CNS). Although neurotransmission has been recently clarified as a key modulator of retinal circuit development, the roles of individual synaptic transmissions are not yet fully understood. In the current study, we investigated the role of neurotransmission from photoreceptor cells to ON bipolar cells in development using mutant mouse lines of both sexes in which this transmission is abrogated. We found that deletion of the ON bipolar cation channel TRPM1 results in the abnormal contraction of rod bipolar terminals and a decreased number of their synaptic connections with amacrine cells. In contrast, these histological alterations were not caused by a disruption of total glutamate transmission due to loss of the ON bipolar glutamate receptor mGluR6 or the photoreceptor glutamate transporter VGluT1. In addition,TRPM1deficiency led to the reduction of total dendritic length, branch numbers, and cell body size in AII amacrine cells. Activated Goα, known to close the TRPM1 channel, interacted with TRPM1 and induced the contraction of rod bipolar terminals. Furthermore, overexpression of Channelrhodopsin-2 partially rescued rod bipolar cell development in theTRPM1−/−retina, whereas the rescue effect by a constitutively closed form of TRPM1 was lower than that by the native form. Our results suggest that TRPM1 channel opening is essential for rod bipolar pathway establishment in development.SIGNIFICANCE STATEMENTNeurotransmission has been recognized recently as a key modulator of retinal circuit development in the CNS. However, the roles of individual synaptic transmissions are not yet fully understood. In the current study, we focused on neurotransmission between rod photoreceptor cells and rod bipolar cells in the retina. We used genetically modified mouse models which abrogate each step of neurotransmission: presynaptic glutamate release, postsynaptic glutamate reception, or transduction channel function. We found that the TRPM1 transduction channel is required for the development of rod bipolar cells and their synaptic formation with subsequent neurons, independently of glutamate transmission. This study advances our understanding of neurotransmission-mediated retinal circuit refinement.
Prediction and Subtyping of Hypertension from Pan-Tissue Transcriptomic and Genetic Analyses
Authors: Basu Mahashweta , Sharmin Mahfuza , Das Avinash , Nair Nishanth Ulhas , Wang Kun , Lee Joo Sang , Chang Yen-Pei Christy , Ruppin Eytan , Hannenhalli Sridhar 
Published: September 2017

AbstractHypertension (HT) is a complex systemic disease involving transcriptional changes in multiple organs. Here we systematically investigate the pan-tissue transcriptional and genetic landscape of HT spanning dozens of tissues in hundreds of individuals. We find that in several tissues, previously identified HT-linked genes are dysregulated and the gene expression profile is predictive of HT. Importantly, many expression quantitative trait loci (eQTL) SNPs associated with the population variance of the dysregulated genes are linked with blood pressure in an independent genome-wide association study, suggesting that the functional effect of HT-associated SNPs may be mediated through tissue-specific transcriptional dysregulation. Analyses of pan-tissue transcriptional dysregulation profile, as well as eQTL SNPs underlying the dysregulated genes, reveals substantial heterogeneity among the HT patients, revealing two broad groupings – a Diffused group where several tissues exhibit HT-associated molecular alterations and a Localized group where such alterations are localized to very few tissues. These two patient subgroups differ in several clinical phenotypes including respiratory, cerebrovascular, diabetes, and heart disease. These findings suggest that the Diffused and Localized subgroups may be driven by different molecular mechanisms and have different genetic underpinning.
Improving Disease Prediction by Incorporating Family Disease History in Risk Prediction Models with Large-Scale Genetic Data
Authors: Gim Jungsoo , Kim Wonji , Kwak Soo Heon , Choi Hosik , Park Changyi , Park Kyong Soo , Kwon Sunghoon , Park Taesung , Won Sungho 
Published: September 2017

AbstractDespite the many successes of genome-wide association studies (GWAS), the known susceptibility variants identified by GWAS have modest effect sizes, leading to notable skepticism about the effectiveness of building a risk prediction model from large-scale genetic data. However, in contrast to genetic variants, the family history of diseases has been largely accepted as an important risk factor in clinical diagnosis and risk prediction. Nevertheless, the complicated structures of the family history of diseases have limited their application in clinical practice. Here, we developed a new method that enables incorporation of the general family history of diseases with a liability threshold model, and propose a new analysis strategy for risk prediction with penalized regression analysis that incorporates both large numbers of genetic variants and clinical risk factors. Application of our model to type 2 diabetes in the Korean population (1846 cases and 1846 controls) demonstrated that single-nucleotide polymorphisms accounted for 32.5% of the variation explained by the predicted risk scores in the test data set, and incorporation of family history led to an additional 6.3% improvement in prediction. Our results illustrate that family medical history provides valuable information on the variation of complex diseases and improves prediction performance.
Vector-borne diseases in cats in Germany
Authors: Hartmann Katrin , Bergmann Michèle 
Published: September 2017

SummaryVector-borne diseases (VBDs) are caused by a wide range of pathogens, which are transmitted by a variety of vectors, such as ticks and fleas. As a result of climate changes, more vector-borne diseases are becoming endemic in Germany, not only in dogs, but also in cats. For some of the pathogens prevalence data still need to be investigated in Germany. However, natural infections with Bartonella, Anaplasma, haemotropic Mycoplasma and Borrelia species have already been described in German cats. Clinical relevance of these pathogens is not fully understood, and it is still unknown, why most infected cats stay asymptomatic and which predisposing factors contribute to the development of clinical signs in cats. Moreover, there is a risk of zoonotic transmission for some of the pathogens, e. g., for some Bartonella spp. infections that are associated with cat scratch disease in humans. Due to the increasing number of VBDs in cats in Germany, preventive measures, such as the use of acaricides and insecticides, should be performed on a regular base in order to reduce the risk of these infections.
Associação entre o deslocamento para a escola e aptidão física relacionada ao desempenho motor em escolares
Authors: Pires Aillyn Lyanna , Soares Silvana Silveira , Welser Letícia , Silva Cristiane Fernanda da , Sehn Ana Paula , Kern Deise Graziela , Valim Andréia Rosane deMoura , Reuter Cézane Priscila , Burgos Miria Suzana 
Published: September 2017

Justificativa e objetivos: Aptidão física e desempenho motor são importantes preditores de risco cardiovascular em crianças e adolescentes. O presente estudo transversal objetiva verificar se existe associação entre o deslocamento para a escola e aptidão física relacionada ao desempenho motor em escolares.
Métodos: A amostra é composta por 751 crianças e adolescentes, sendo 349 do sexo feminino, com idades entre 7 e 17 anos, residentes do município de Santa Cruz do Sul-RS. Para a avaliação do deslocamento para a escola, foi utilizado um questionário. A avaliação da aptidão física relacionada ao desempenho motor foi realizada por meio dos testes de agilidade, velocidade, força de membros superiores e inferiores.
Resultados: A maior parte dos meninos (81,4%) e das meninas (84,1%) se deslocam de forma sedentária para a escola, sendo que as meninas que se deslocam de forma ativa para a escola apresentam melhores níveis de força de membros superiores (p=0,023) e de velocidade (p=0,003). Entre os meninos, não foi observada diferença significativa para os indicadores de aptidão física relacionada ao desempenho motor, de acordo com o tipo de deslocamento para a escola.
Conclusão: Constatou-se que meninas que se deslocam de forma ativa para a escola apresentam melhores resultados nos testes de aptidão física relacionada ao desempenho motor.
Рефлексивный подход как педагогическая проблема
Authors: Бурдякова Любовь Сергеевна 
Published: September 2017

<p>В статье показана сущность рефлексии в педагогической науке, которая состоит во взгляде на себя и свои действия, эмоции, душевные состояния «со стороны». Рефлексия способствует самообучению, самоанализу и самоконтролю на всех этапах обучения, позволяет нам не только разобраться в себе, но и дает возможность понять окружающих нас людей. </p>
A constituição do Reino da Suécia, o estado-providência e o estado mínimo
Authors: Camargo Ricardo Antonio Lucas 
Published: September 2017

Resumo: O presente ensaio volta-se, diante do recorrente discurso de minimização do Estado como o verdadeiro caminho para o bem-estar geral, a examinar a veracidade das proposições que têm sido frequentes em relação ao Reino da Suécia, particularmente no que tange ao modo de gestão da res publica e à passagem de um modelo econômico de Estado Providência para o de um Estado Mínimo. A verificação dessas premissas foi realizada pelo estudo da formação da Suécia enquanto Estado, bem como da distribuição dos poderes no âmbito deste, para se ingressar no tratamento dos temas econômicos por parte do ordenamento jurídico, destacados a propriedade, o trabalho, a atividade empresarial, a atuação do Estado em face do domínio econômico e os serviços públicos. Uma vez que o artigo se constrói pelo teste das proposições gerais, impõe-se a adoção do método indutivo.Palavras-chave: Constituição Econômica. Suécia. Estado Providência. Abstract: This essay intends, facing the continuous speech on reducing the State as the real way to the general welfare, to investigate the truth on propositions related to the Kingdom of Sweden, specially on what concerns the way of managing res publica and the transition from an economic model of a Welfare State to a Minimal State. These premises verification were made through the formation of Sweden as a State, as well as the distribution of powers inside it, in order to come into legal treatment of economic themes, with emphasis on property, work, business activity, State action in economic field and public utilities. Inductive method is, here, imperative, for this essay is built by testing general propositions.Keywords: Economic Constitution. Sweden. Welfare State.
Revendo mais de 70 anos em menos de 7 meses: a tramitação da reforma trabalhista do governo Temer
Authors: Di Benedetto Roberto 
Published: September 2017

Resumo: A reforma trabalhista do Governo Temer, aprovada no primeiro semestre de 2017, no meio de uma grave crise política e econômica, modificou profundamente o direito do trabalho, o Poder Judiciário e a estrutura sindical. A rápida tramitação da reforma, sua extensão e a ausência de um debate público dificultaram a análise dos seus impactos. Neste estudo de caso teve-se por objetivo analisar a tramitação da reforma trabalhista no Congresso e os principais argumentos utilizados pelos deputados e senadores que discutiram a proposta. Com isso, espera-se contribuir com a discussão das normas aprovadas e com a análise de suas consequências no mercado de trabalho, no Poder Judiciário e na estrutura sindical.Palavras-chave: Reforma trabalhista. Justiça do trabalho. Estrutura sindical. Abstract: The Temer government’s labor reform, approved in the first half of 2017, in the middle of a serious political and economic crisis, changed labor law, the Judiciary, and the trade union structure. The fast reform process, its extension, and the absence of public debate made difficult to analyze its impacts. This leading case aimed to examine the process of labor reform in Congress and the main arguments used by the deputies and senators who discussed the proposal. With this, it is hoped to contribute to the discussion of the approved norms and the analysis of their consequences in the labor market, in the Judiciary and in the union structure.Keywords: Labor reform. Labor courts. Trade unions.
Fotografia e tecnologia: o pós-morte no Brasil oitocentista
Authors: Marcondes Marli 
Published: September 2017

O presente trabalho pretende abordar a questão da morte, não em toda sua complexidade, quer seja no âmbito da sociologia, da história, da antropologia ou da saúde, mas estabelecer um paralelo entre a representação da morte no século XIX, a partir dos preceitos culturais e religiosos da sociedade ocidental e brasileira, com as transformações tecnológicas ocorridas no campo da fotografia no mesmo período.
Revelando imagens da Congada: fotografia, memória e pesquisa etnográfica
Authors: Cesar Lilian Sagio 
Published: September 2017

Opresente texto tem como objetivo discutir algumas das especificidades da pesquisa desenvolvida a partir da utilização e realização de imagens, em especial as fotográficas, em Antropologia. A partir de pesquisa de campo junto aos congadeiros e moçambiqueiros do município mineiro de São Sebastião do Paraíso, e da proposta de realizar e devolver fotografias de sua tradicional Festa de Congada, foram construídos feixes de relações que permitiram a realização da pesquisa focando as especificidades desta festa, visando o acesso a algumas das profundas camadas de significados das ações, representações e memórias de seus dançadores mais dedicados, elementos estes que geralmente permanecem restritos aos fechados círculos dos realizadores em forma de fundamento ou segredo.
Uma memória das africanidades
Authors: Camargo Denise 
Published: September 2017

No embarque forçado para a travessia transatlântica, os negros africanos capturados pela escravidão marcavam a separação de suas origens por meio de um ritual. Homens deveriam dar nove voltas e mulheres, sete (Barbieri, 1998) em torno de um frondoso, imponente, acolhedor e centenário baobá que ficaria conhecido como a “árvore do esquecimento”...
Analisis Pengaruh T-Shaped Slot terhadap Kualitas Parameter Antena Mikrostrip menggunakan Computer Simulation Technology (CST) dan Advanced Design System (ADS) untuk Aplikasi Wi-Fi
Authors: Nugraha Eka Setia , Paramitha Widyana , Amalia Norma 
Published: September 2017

Microstrip antenna is widely used because it has several advantages such as small dimension and light weight. However, this antenna also has weaknesses, which are limited bandwidth and low gain. Therefore, this antenna is designed for the purpose of obtaining a wide bandwidth. This research is to design and simulate a microstrip patch antenna rectangular T- shaped slot to support wi-fi communication and using stripline as a transmission line. An antenna designed for the purpose of obtaining a wide bandwidth, is expected to produce the characteristics of antennas working at a resonant frequency of 2447 MHz for VSWR less than 2 with the type of substrate used is FR4 Epoxy with a relative permittivity value is 4.4, dielectric constanta is 2,2, and the thickness is 1,6, also impedance of transmission line is 50 ? that operate in frequency resonant 2,447 GHz. According to design and simulation this antenna, value of bandwidth impedance is about 103 MHz for VSWR 1,367, gain about 5,337 dB, and directivity about 6,238 dBi. And the result of simulation on ADS simulator, the value of VSWR is 2,083, with gain about 0,505 dB, and directivity about 6,063 dBi.
Modifikasi Headstega berdasarkan Penyisipan Karakter
Authors: Hasmawati Hasmawati 
Published: September 2017

<p align="center"><strong>Abstract</strong><strong></strong></p><p>Head steganography or Headstega is one of noiseless steganography paradigm, or Nostega.This method utilizes the email header as a media of message concealment. There are several problems that can be enhanced in Headstega, i.e. low embedding capacity and high level of suspicion. Modified Headstega based on Character Hiding uses a combination of consonant vowel to embed the secret messages into email address. The messages embedding process using four consonant vowel combination that represented one character in Indonesian language. From the experiments conducted, the results obtained that the Modified Headstega has a better performance than the Original Headstega in term of embedding capacity and also in suspicion level.</p><p><strong> </strong><strong>Keyword</strong> : Steganography, Nostega, Headstega, Character Hiding</p>
Penggunaan Metode berbasis Graph untuk Mining Frequent Sequential Access Pattern Pada Studi Kasus : Website iGracias Universitas Telkom
Authors: Rohdiniyah Rahmi , Asror Ibnu , Ary Wisudawan Gede Agung 
Published: September 2017

Penggunaan <em>website</em> pada bidang pendidikan, khususnya sebuah universitas, bertujuan untuk menyimpan berbagai informasi yang ada pada lingkungan universitas tersebut. Untuk itu, perlu dilakukan perbaikan struktur untuk memelihara kualitas dari web. Salah satu teknik yang dapat digunakan adalah dengan menggunakan <em>web usage mining. Web usage mining</em> merupakan salah satu cabang dari <em>web mining</em> yang digunakan untuk menemukan informasi atau pengetahuan yang bermanfaat dari pola navigasi <em>user </em>pada sebuah<em> website</em>. Pada penelitian ini menggunakan metode berbasis graph untuk <em>frequent sequential access patterns</em> dan menggunakan Igracias Universitas Telkom sebagai studi kasusnya. Karena Igracias selalu digunakan oleh seluruh entitas yang ada pada Universitas Telkom. Metode ini memiliki kelebihan untuk menemukan <em>behavior</em> pola pengaksesan <em>user</em>. Dari implementasi metoda ini didapat pola akses group user secara berurutan.
SALA DE AULA INVERTIDA: UMA METODOLOGIA ATIVA DE APRENDIZAGEM -FLIP YOUR CLASSROOM: REACH EVERY STUDENT IN EVERY CLASS EVERY DAY.
Authors: Lostada Lauro Roberto 
Published: September 2017

Resenha sobre o livro Sala de aula invertida: Uma metodologia ativa de aprendizagem, de Jonathan Bergmann e Aaron Sams.
Considerations for the design of bottom intake systems
Authors: Carrillo José M. , Castillo Luis G. , García Juan T. , Sordo-Ward Álvaro 
Published: September 2017

Abstract
Knowing the scarcity of water in the southeast of Spain and how the rain occurs, we considered the design of intake systems in ephemeral riverbeds in order to try to capture part of the runoff flow. The intake systems generally consist of a rack located in the bottom of a river channel, so that the water collected passes down the rack and leads to the side channel. This behaviour has been studied in the laboratory by several researchers. However, due to the many effects that occur on the bars, it is not possible to analyse the whole problem of characterization with traditional methodologies. For instance, the wetted rack length necessary to collect a required flow presents important differences depending on what each author has considered relevant. Computational fluid dynamics simulations have been done to improve the knowledge of the hydraulic phenomenon observed in different laboratory experiences, for which we have previously calibrated the numerical models using laboratory results. The ANSYS CFX code was selected. Several two-equation turbulence models have been considered. The results show differences smaller than 1% in the wetted rack length, and discharge coefficients also present good agreement.
The Beneficial Effects of Sulfur-containing Amino Acids on Cisplatininduced Cardiotoxicity and Neurotoxicity in Rodents
Authors: Rosic Gvozden , Joksimovic Jovana , Selakovic Dragica , Jakovljevic Vladimir , Zivkovic Vladimir , Srejovic Ivan , Djuric Marko , Djuric Dragan 
Published: September 2017

Background:
Cisplatin is one the most frequently used chemotherapeutic drugs for several
decades. Although its antineoplastic effect has been reported in treatment of numerous malignances,
various adverse effects seem to be the crucial limiting factor for its administration.

Objective:
Beside the most commonly described nephro- and hepatotoxicity, cisplatin therapy is also
accompanied with gastrointestinal, reproductive, hematological, cardiovascular and neurological side
effects. Since it has been reported that cisplatin induce oxidative damage in various tissues, it seems reasonable
to investigate an antioxidant supplementation as potential therapeutical approach for attenuation
of cisplatin toxicities.

Methods:
We performed a structured search of bibliographic databases for research literature using a
focused review question and inclusion/exclusion criteria. The quality of retrieved papers (101 in total)
was appraised using standard tools.

Results:
Numerous antioxidants (such as thiol compounds, polyphenols, vitamins, etc.) had been reported
for their beneficial effects on cisplatin-induced cardiotoxicity. The effects of various antioxidants, including
sulfur-containing amino acids, have also been explored for mitigation of cisplatin neurotoxicity.
However, the results for antioxidant supplementation in reduction of cisplatin-induced toxicities are still
to be applied in clinical trials.

Conclusion:
Considering the facts that sulfur-containing amino acids: (a) do not interfere with chemotherapeutics
antitumor action; (b) do not exhibit any toxic effect (unless applied in dose several times
above the recommended); and (c) produce significant protective effects on some cisplatin-induced toxicities
connected to augmentation of oxidative damage - it seems that their administration can be harmless
and protective supplementation against numerous adverse effects of certain antineoplastic agents.
Regionalización de curvas de duración de caudales en el Departamento de Antioquia-Colombia
Authors: Gallego Arias Santiago , Carvajal Serna Luis Fernando 
Published: September 2017

Los diseños y aprovechamientos en recursos hidráulicos requieren de la información y procesamiento de datos necesario para el éxito de las obras propuestas. Muchas veces los registros de caudal no están disponibles en la cuenca hidrográfica de estudio y uno de los conceptos más usados es la curva de duración de caudales. Este trabajo propone un nuevo acercamiento a la regionalización de la curva de duración de caudales en cuencas sin información. El enfoque presenta una ecuación para cada una de las 6 regiones en que se dividió el departamento de Antioquia, en la parte noroeste de Colombia. La propuesta tiene como variable adicional al enfoque tradicional, la inclusión de la probabilidad de no excedencia. El análisis estadístico realizado muestra que el error de ajuste es menor del 13% para todas las regiones de Antioquia con excepción de la región de Urabá, que es del 44%.