bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences
Authors: Assaf Roxane , Ouellet Julien , Bourque Josiane , Stip Emmanuel , Leyton Marco , Conrod Patricia , Potvin Stéphane 
Published: September 2024

Abstract
Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth (n = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders.
Responding to epidemics: the case of the Nguyễn Dynasty, focusing on the period 1802–1883
Authors: Nguyễn Thị Oanh , Trần Thị Minh 
Published: September 2024

Abstract
In the past, Vietnam was impacted by numerous epidemics, particularly during the Nguyễn Dynasty from 1802 to 1883. Based on data from the Đại Nam Thực Lục (1961) (The Veritable Records of the Great South), this article investigates the frequency and nature of these epidemics, identifies the types of common diseases at that time, and explores the underlying causes of these outbreaks. The study further examines the Nguyễn Dynasty's strategies for managing these health crises. During these outbreaks, the dynasty faced significant challenges, with frequent epidemics leading to high death rates, widespread social disruption, and economic decline. The dynasty's primary preventive measures, heavily reliant on spiritual practices like prayer, highlight the limited medical understanding at the time and the constraints of its socio-political framework. However, there was a progressive shift towards the incorporation of Western medical innovations, particularly in the vaccine approach to treat diseases like smallpox. This transition not only marked a critical evolution in the local healthcare approach but also set the stage for more systematic medical advancements in Vietnam during the colonial period (1884–1945).
The political economy of China's Belt and Road Initiative
Authors: Caskey Gregory W. 
Published: September 2024

Abstract
The Belt and Road Initiative (BRI) is the Chinese government's effort to promote global development and interconnectivity through a vast network of transportation, energy, and telecommunications infrastructure projects. Involving over 140 countries, Beijing has clearly stated aims and methods for the Belt and Road, including that BRI contributes to economic development in participant countries and that all projects be carried out according to ‘five cooperation priorities’ representing win–win partnerships between China and BRI-participant countries. Taking China's stated aims as given, this paper argues that Beijing faces information and institutional constraints that prevent the successful planning, implementation, and operation of BRI. By employing ill-suited means to achieve their stated ends, Beijing undermines their own ability to carry out BRI successfully. This paper explores the mechanisms at work on the ground within BRI, utilizing case studies of BRI's flagship projects and BRI contract data as evidence for the theory.
Impact of Warehouse Expansion on Ambient PM2.5 and Elemental Carbon Levels in Southern California's Disadvantaged Communities: A Two‐Decade Analysis
Authors: Yang Binyu , Zhu Qingyang , Wang Wenhao , Zhu Qiao , Zhang Danlu , Jin Zhihao , Prasad Prachi , Sowlat Mohammad , Pakbin Payam , Ahangar Faraz , Hasheminassab Sina , Liu Yang 
Published: September 2024

AbstractOver the past two decades, the surge in warehouse construction near seaports and in economically lower‐cost land areas has intensified product transportation and e‐commerce activities, particularly affecting air quality and health in nearby socially disadvantaged communities. This study, spanning from 2000 to 2019 in Southern California, investigated the relationship between ambient concentrations of PM2.5 and elemental carbon (EC) and the proliferation of warehouses. Utilizing satellite‐driven estimates of annual mean ambient pollution levels at the ZIP code level and linear mixed effect models, positive associations were found between warehouse characteristics such as rentable building area (RBA), number of loading docks (LD), and parking spaces (PS), and increases in PM2.5 and EC concentrations. After adjusting for demographic covariates, an Interquartile Range increase of the RBA, LD, and PS were associated with a 0.16 μg/m³ (95% CI = [0.13, 0.19], p < 0.001), 0.10 μg/m³ (95% CI = [0.08, 0.12], p < 0.001), and 0.21 μg/m³ (95% CI = [0.18, 0.24], p < 0.001) increase in PM2.5, respectively. For EC concentrations, an IQR increase of RBA, LD, and PS were each associated with a 0.021 μg/m³ (95% CI = [0.019, 0.024], p < 0.001), 0.014 μg/m³ (95% CI = [0.012, 0.015], p < 0.001), and 0.021 μg/m³ (95% CI = [0.019, 0.024], p < 0.001) increase. The study also highlighted that disadvantaged populations, including racial/ethnic minorities, individuals with lower education levels, and lower‐income earners, were disproportionately affected by higher pollution levels.
Spatial Distribution in Surface Aerosol Light Absorption Across India
Authors: Kapoor Taveen S. , Navinya Chimurkar , Apte Adishree , Shetty Nishit J. , Lokhande Pradnya , Singh Sujit , Murthy B. M. Sadashiva , Deswal Meena , Laura Jitender S. , Muthalagu Akila , Qureshi Asif , Bhardwaj Ankur , Sunder Raman Ramya , Lian Yang , Pandithurai G. , Chaudhary Pooja , Sinha Baerbel , Rabha Shahadev , Saikia Binoy K. , Najar Tanveer Ahmad , Jehangir Arshid , Mukherjee Sauryadeep , Chatterjee Abhijit , Phuleria Harish C. , Chakrabarty Rajan K. , Venkataraman Chandra 
Published: September 2024

AbstractLight‐absorbing carbonaceous aerosols that dominate atmospheric aerosol warming over India remain poorly characterized. Here, we delve into UV‐visible‐IR spectral aerosol absorption properties at nine PAN‐India COALESCE network sites (Venkataraman et al., 2020, https://doi.org/10.1175/bams‐d‐19‐0030.1). Absorption properties were estimated from aerosol‐laden polytetrafluoroethylene filters using a well‐constrained technique incorporating filter‐to‐particle correction factors. The measurements revealed spatiotemporal heterogeneity in spectral intrinsic and extrinsic absorption properties. Absorption analysis at near‐UV wavelengths from carbonaceous aerosols at these regional sites revealed large near‐ultraviolet brown carbon absorption contributions from 21% to 68%—emphasizing the need to include these particles in climate models. Further, satellite‐retrieved column‐integrated absorption was dominated by surface absorption, which opens possibilities of using satellite measurements to model surface‐layer optical properties (limited to specific sites) at a higher spatial resolution. Both the satellite‐modeled and direct in‐situ absorption measurements can aid in validating and constraining climate modeling efforts that suffer from absorption underestimations and high uncertainties in radiative forcing estimates.
A Slowdown in Translation Speed of Western North Pacific Tropical Cyclones Undergoing Rapid Intensification
Authors: Song Jinjie , Klotzbach Philip J. , Dai Yifei , Duan Yihong 
Published: September 2024

AbstractThis study examines long‐term trends in western North Pacific (WNP) tropical cyclones (TCs) experiencing rapid intensification (RI) from 1971 to 2022. Although there is only a weak slowdown for all intensifying WNP TCs, the average translation speed for RI TCs has significantly decelerated over the RI main development region (7.5°–25°N, 115°–160°E). This slowdown is primarily due to increasing RI probabilities for slower‐moving TCs. By contrast, the RI probability of faster‐moving TCs remains virtually unchanged. These differences in RI trend probabilities between slow‐moving and fast‐moving TCs are primarily linked to a deepening of the WNP mixed layer. TC‐induced sea surface temperature cooling tends to weaken when the mixed layer is deep. During the intensification stage, the deeper mixed layer is more critical for slower‐moving TCs than for faster‐moving TCs. Our findings suggest that RI probabilities for slow‐moving WNP TCs may continue to increase in a future warming climate.
Phase-change VO2-based thermochromic smart windows
Authors: Jiang Cancheng , He Lanyue , Xuan Qingdong , Liao Yuan , Dai Jian-Guo , Lei Dangyuan 
Published: September 2024

AbstractThermochromic coatings hold promise in reducing building energy consumption by dynamically regulating the heat gain of windows, which are often regarded as less energy-efficient components, across different seasons. Vanadium dioxide (VO2) stands out as a versatile thermochromic material for smart windows owing to its reversible metal-to-insulator transition (MIT) alongside correlated structural and optical properties. In this review, we delve into recent advancements in the phase-change VO2-based thermochromic coatings for smart windows, spanning from the macroscopic crystal level to the microscopic structural level (including elemental doping and micro/nano-engineering), as well as advances in controllable fabrication. It is notable that hybridizing functional elements/materials (e.g., W, Mo/SiO2, TiN) with VO2 in delicate structural designs (e.g., core-shell, optical cavity) brings new degrees of freedom for controlling the thermochromic properties, including the MIT temperature, luminous transmittance, solar-energy modulation ability and building-relevant multi-functionality. Additionally, we provide an overview of alternative chromogenic materials that could potentially complement or surpass the intrinsic limitations of VO2. By examining the landscape of emerging materials, we aim to broaden the scope of possibilities for smart window technologies. We also offer insights into the current challenges and prospects of VO2-based thermochromic smart windows, presenting a roadmap for advancing this field towards enhanced energy efficiency and sustainable building design. In summary, this review innovatively categorizes doping strategies and corresponding effects of VO2, underscores their crucial NIR-energy modulation ability for smart windows, pioneers a theoretical analysis of inverse core-shell structures, prioritizes practical engineering strategies for solar modulation in VO2 films, and summarizes complementary chromogenic materials, thus ultimately advancing VO2-based smart window technologies with a fresh perspective.
Role of serotonin neurons in the dorsal raphe nucleus in heroin self-administration and punishment
Authors: Li Chen , McCloskey Nicholas S. , Inan Saadet , Kirby Lynn G. 
Published: September 2024

Abstract
One hallmark of substance use disorder is continued drug use despite negative consequences. When drug-taking behavior is punished with aversive stimuli, i.e. footshock, rats can also be categorized into punishment-resistant or compulsive vs. punishment-sensitive or non-compulsive phenotypes. The serotonin (5-hydroxytryptamine, 5-HT) system modulates responses to both reward and punishment. The goal of the current study was to examine punishment phenotypes in heroin self-administration and to determine the role of dorsal raphe nucleus (DRN) 5-HT neurons in both basal and punished heroin self-administration. First, rats were exposed to punished heroin self-administration and neuronal excitability of DRN 5-HT neurons was compared between punishment-resistant and punishment-sensitive phenotypes using ex vivo electrophysiology. Second, DRN 5-HT neuronal activity was manipulated in vivo during basal and punished heroin self-administration using chemogenetic tools in a Tph2-iCre rat line. While rats separated into punishment-resistant and punishment-sensitive phenotypes for punished heroin self-administration, DRN 5-HT neuronal excitability did not differ between the phenotypes. While chemogenetic inhibition of DRN 5-HT neurons was without effect, chemogenetic activation of DRN 5-HT neurons increased both basal and punished heroin self-administration selectively in punishment-resistant animals. Additionally, the responsiveness to chemogenetic activation of DRN 5-HT neurons in basal self-administration and motivation for heroin in progressive ratio each predicted resistance to punishment. Therefore, our data support the role for the DRN 5-HT system in compulsive heroin self-administration.
Kindlin-2 regulates the oncogenic activities of integrins and TGF-β in triple-negative breast cancer progression and metastasis
Authors: Yousafzai Neelum Aziz , El Khalki Lamyae , Wang Wei , Szpendyk Justin , Sossey-Alaoui Khalid 
Published: September 2024

AbstractKindlin-2, an adapter protein, is dysregulated in various human cancers, including triple-negative breast cancer (TNBC), where it drives tumor progression and metastasis by influencing several cancer hallmarks. One well-established role of Kindlin-2 involves the regulation of integrin signaling, achieved by directly binding to the cytoplasmic tail of the integrin β subunit. In this study, we present novel insights into Kindlin-2’s involvement in stabilizing the β1-Integrin:TGF-β type 1 receptor (TβRI) complexes, acting as a physical bridge that links β1-Integrin to TβRI. Loss of Kindlin-2 results in the degradation of this protein complex, leading to the inhibition of downstream oncogenic pathways. We used a diverse range of in vitro assays, including CRISPR/Cas9 gene editing, cell migration, 3D-tumorsphere formation and invasion, solid binding, co-immunoprecipitation, cell adhesion and spreading assays, as well as western blot and flow cytometry analyses, utilizing MDA-MB-231 and 4T1 TNBC cell lines. Additionally, preclinical in vivo mouse models of TNBC tumor progression and metastasis were employed to substantiate our findings. Our studies established the direct interaction between Kindlin-2 and β1-Integrin and between Kindlin-2 and TβRI. Disruption of these interactions, via CRISPR/Cas9-mediated knockout of Kindlin-2, led to the degradation of β1-Integrin and TβRI, resulting in the inhibition of oncogenic pathways downstream of both proteins, subsequently hindering tumor growth and metastasis. Treatment of Kindlin-2-deficient cells with the proteasome inhibitor MG-132 restored the expression of both β1-Integrin and TβRI. Furthermore, the rescue of Kindlin-2 expression reinstated their oncogenic activities in vitro and in vivo, while Kindlin-2 lacking domains involved in the interaction of Kindlin-2 with β1-Integrin or TβRI did not. This study identifies a novel function of Kindlin-2 in stabilizing the β1-Integrin:TβRI complexes and regulating their downstream oncogenic signaling. The translational implications of these findings are substantial, potentially unveiling new therapeutically targeted pathways crucial for the treatment of TNBC tumors.
Prediction of the Cu oxidation state from EELS and XAS spectra using supervised machine learning
Authors: Gleason Samuel P. , Lu Deyu , Ciston Jim 
Published: September 2024

AbstractElectron energy loss spectroscopy (EELS) and X-ray absorption spectroscopy (XAS) provide detailed information about bonding, distributions and locations of atoms, and their coordination numbers and oxidation states. However, analysis of XAS/EELS data often relies on matching an unknown experimental sample to a series of simulated or experimental standard samples. This limits analysis throughput and the ability to extract quantitative information from a sample. In this work, we have trained a random forest model capable of predicting the oxidation state of copper based on its L-edge spectrum. Our model attains an R2 score of 0.85 and a root mean square error of 0.24 on simulated data. It has also successfully predicted experimental L-edge EELS spectra taken in this work and XAS spectra extracted from the literature. We further demonstrate the utility of this model by predicting simulated and experimental spectra of mixed valence samples generated by this work. This model can be integrated into a real-time EELS/XAS analysis pipeline on mixtures of copper-containing materials of unknown composition and oxidation state. By expanding the training data, this methodology can be extended to data-driven spectral analysis of a broad range of materials.
Multidrug-resistant high-risk clonal Escherichia coli lineages occur along an antibiotic residue gradient in the Baltic Sea
Authors: Lübcke Phillip , Heiden Stefan E. , Homeier-Bachmann Timo , Bohnert Jürgen A. , Schulze Christian , Eger Elias , Schwabe Michael , Guenther Sebastian , Schaufler Katharina 
Published: September 2024

AbstractThe global spread of multidrug-resistantEscherichia colithreatens human, animal, and environmental health. Despite the recognition of water bodies as potential reservoirs, research on antimicrobial resistance (AMR) and antibiotic residues in the Baltic Sea is limited. In this study, we examined the presence of ESBL-producingE. coliin surface water in northeastern Germany. We then conducted phenotypic and genotypic analyses of the strains, which encompassed AMR and heavy metal/metalloid tolerance, biofilm formation, and detailed plasmid examination. In addition, we used solid-phase extraction with ultra-high performance liquid chromatography and mass spectrometry to quantify antibiotic residues. Our analysis identified 30 ESBL-producingE. coliisolates, some of which were associated with clinically relevant high-risk clonal lineages. We detected antibiotic residues in the environmental samples, but the antibiotic concentrations were significantly lower compared to wastewater samples. These results suggest that the Baltic Sea surface water could serve as a reservoir for ESBL-producingE. coliand clinically relevant antibiotics.
Earth-abundant Li-ion cathode materials with nanoengineered microstructures
Authors: Hau Han-Ming , Mishra Tara , Ophus Colin , Huang Tzu-Yang , Bustilo Karen , Sun Yingzhi , Yang Xiaochen , Holstun Tucker , Zhao Xinye , Wang Shilong , Ha Yang , Lee Gi-Hyeok , Song Chengyu , Turner John , Bai Jianming , Ma Lu , Chen Ke , Wang Feng , Yang Wanli , McCloskey Bryan D. , Cai Zijian , Ceder Gerbrand 
Published: September 2024

AbstractManganese-based materials have tremendous potential to become the next-generation lithium-ion cathode as they are Earth abundant, low cost and stable. Here we show how the mobility of manganese cations can be used to obtain a unique nanosized microstructure in large-particle-sized cathode materials with enhanced electrochemical properties. By combining atomic-resolution scanning transmission electron microscopy, four-dimensional scanning electron nanodiffraction and in situ X-ray diffraction, we show that when a partially delithiated, high-manganese-content, disordered rocksalt cathode is slightly heated, it forms a nanomosaic of partially ordered spinel domains of 3–7 nm in size, which impinge on each other at antiphase boundaries. The short coherence length of these domains removes the detrimental two-phase lithiation reaction present near 3 V in a regular spinel and turns it into a solid solution. This nanodomain structure enables good rate performance and delivers 200 mAh g−1 discharge capacity in a (partially) disordered material with an average primary particle size of ∼5 µm. The work not only expands the synthesis strategies available for developing high-performance Earth-abundant manganese-based cathodes but also offers structural insights into the ability to nanoengineer spinel-like phases.
Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
Authors: Korte Nils , Barkaway Anna , Wells Jack , Freitas Felipe , Sethi Huma , Andrews Stephen P. , Skidmore John , Stevens Beth , Attwell David 
Published: September 2024

AbstractEarly in Alzheimer’s disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and, thus, decreasing cerebral blood flow (CBF). Therapeutic approaches to attenuate pericyte-mediated constriction in AD are lacking. Here, using in vivo two-photon imaging with laser Doppler and speckle flowmetry and magnetic resonance imaging, we show that Ca2+ entry via L-type voltage-gated calcium channels (CaVs) controls the contractile tone of pericytes. In AD model mice, we identifed pericytes throughout the capillary bed as key drivers of an immune reactive oxygen species (ROS)-evoked and pericyte intracellular calcium concentration ([Ca2+]i)-mediated decrease in microvascular flow. Blocking CaVs with nimodipine early in disease progression improved CBF, reduced leukocyte stalling at pericyte somata and attenuated brain hypoxia. Amyloid β (Aβ)-evoked pericyte contraction in human cortical tissue was also greatly reduced by CaV block. Lowering pericyte [Ca2+]i early in AD may, thus, offer a therapeutic strategy to enhance brain energy supply and possibly cognitive function in AD.
A reduced-scale canyon street to study tree climate benefits: summer 2020 data with well-watered apple trees
Authors: Herpin Sophie , Mballo Souleymane , Manteau Melvin , Lemesle Dominique , Boukouya Agathe , Dubuc Bénédicte , Ledroit Lydie , Cannavo Patrice , Demotes-Mainard Sabine , Bournet Pierre-Emmanuel 
Published: September 2024

AbstractAn outdoor reduced-scale canyon street was set-up in Angers, France, to study the impact of well-watered trees on urban microclimate and human comfort, with an integrated approach of the soil-plant-atmosphere continuum. Data were acquired during 26 days in summer 2020. The street is oriented north-south, with an aspect ratio of 1. It is organized in three zones: two zones with a central alignment of 5 ornamental apple trees, and one zone without trees. The water inputs are controlled through a drip-irrigation system. Each zone is instrumented to characterise the local microclimate and energy fluxes, the soil water status, and tree leaf temperature. To allow a better understanding of the physical mechanisms at stake in tree services, tree transpiration as well as crown light interception are also quantified, and the trees are characterised in terms of leaf area and crown dimensions. The data can benefit to researchers in urban meteorology and environmental physics. It can also provide reference data to run and evaluate microclimate models, especially regarding plant-atmosphere interactions.