bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-designing services with vulnerable consumers
Authors: Dietrich Timo , Trischler Jakob , Schuster Lisa , Rundle-Thiele Sharyn 
Published: March 2017

Purpose
The purpose of this paper is to investigate how vulnerable consumers can be involved in transformative service design and how this approach may enhance the design of such services. The study also analyzes how co-design with vulnerable consumers differs from existing user involvement processes with the purpose of developing a co-design framework.

Design/methodology/approach
A case study approach was employed, with six high schools in Australia identified as sites to conduct co-design sessions for a school-based alcohol education program. Adolescents were invited to review and (re)design an existing alcohol education program.

Findings
The study indicates that co-design with vulnerable consumers cannot be approached in the same way as conventional user involvement processes. Based on the insights generated from six co-design sessions as well as the examination of user involvement and co-design literature, the authors propose a six-step co-design framework. The six steps comprise resourcing, planning, recruiting, sensitizing, facilitation and evaluation.

Research limitations/implications
The co-design framework illustrates important differences to conventional user involvement processes. However, the generalizability of the research findings is limited to a specific study setting and a narrowly defined sample. Future research in a different setting is needed to further validate the presented findings.

Practical implications
For service design practice, this study provides guidelines on how co-design activities with vulnerable consumers can be effectively resourced, planned, recruited, sensitized, facilitated and evaluated. The framework outlines how co-design may be applied so that vulnerable consumers can become empowered participants during the design process.

Originality/value
This research contributes to the knowledge in transformative service research – a priority in service research – and service design by extending the boundaries of our understanding of processes and tools for the involvement of vulnerable consumers in transformative service design.
Knowledge search and open innovation performance in an emerging market
Authors: Zhang Dan , Li Shengxiao , Zheng Dengpan 
Published: March 2017

PurposeThe purpose of this paper is to examine how knowledge search (KS) affects open innovation performance (OIP) in consideration of appropriability hazard in an emerging market context.Design/methodology/approachThe authors identify two types of appropriability hazard related to KS activities in the improvement of OIP: partner-related and market-related hazards, and construct a model of KS to the OIP with the government-enterprise relationship and market focus (MF) as moderating factors of the analysis framework, using the hierarchical regression analysis based on a survey sample of 258 Chinese companies.FindingsThe authors find that KS has a stronger positive relationship with OIP in international market-focused enterprises compared with domestic market-focused enterprises. In addition, using a configuration approach, the authors find that KS is more positively related to OIP when enterprises have an international MF and a good relationship with the government, but less in other MF government and enterprises relationship configurations.Originality/valueThis paper contributes to previous research work by identifying two types of appropriability hazard related to KS activities in emerging market countries: partner-related and market-related hazards. The authors argue that a positive relationship between KS and OIP is more likely to occur if these appropriability hazards can be mitigated by export MF and a good relationship with the government which has not been demonstrated in previous research.
A comparison among approaches for recommending learning objects through collaborative filtering algorithms
Authors: dos Santos Henrique Lemos , Cechinel Cristian , Araújo Ricardo Matsumura 
Published: March 2017

Purpose
The purpose of this paper is to present the results of a comparison among three different approaches for recommending learning objects (LO) inside a repository. The comparison focuses not only on prediction errors but also on the coverage of each tested configuration.

Design/methodology/approach
The authors compared the offline evaluation by using pure collaborative filtering (CF) algorithms with two other different combinations of pre-processed data. The first approach for pre-processing data consisted of clustering users according to their disciplines resemblance, while the second approach consisted of clustering LO according to their textual similarity regarding title and description. The three methods were compared with respect to the mean average error between predicted values and real values. Moreover, we evaluated the impact of the number of clusters and neighborhood size on the user-coverage.

Findings
Clustering LO has improved the prediction error measure with a small loss on user-coverage when compared to the pure CF approach. On the other hand, the approach of clustering users failed in both the error and in user-space coverage. It also became clear that the neighborhood size is the most relevant parameter to determine how large the coverage will be.

Research limitations
The methods proposed here were not yet evaluated in a real-world scenario, with real users opinions about the recommendations and their respective learning goals. Future work is still required to evaluate users opinions.

Originality/value
This research provides evidence toward new recommendation methods directed toward LO repositories.
Stock return autocorrelation, day of the week and volatility
Authors: Chowdhury Shah Saeed Hassan , Rahman M. Arifur , Sadique M. Shibley 
Published: March 2017

Purpose
The main purpose of this paper is to investigate autocorrelation structure of stock and portfolio returns in a unique market setting of Saudi Arabia, where nearly all active traders are the retail individuals and the market operates under severe limits to arbitrage. Specifically, the authors examine how return autocorrelation of Saudi Arabian stock market is related to factors such as the day of the week, stock trading, performance on the preceding day and volatility.

Design/methodology/approach
The sample consists of the daily stock price and index data of 159 firms listed in Tadawul (Saudi Arabian Stock Exchange) for the period from January 2004 through December 2015. The methodology of Safvenblad (2000) is primarily used to investigate the autocorrelation structure of individual stock and index returns. The authors also use the Sentana and Wadhwani (1992) methodology to test for the presence of feedback traders in the Saudi stock market.

Findings
Results show that there is significantly positive autocorrelation in individual stock, size portfolio and market returns and that the last two are almost always larger than the first. Return autocorrelation is negatively related to firm size. Interestingly, return autocorrelation is positively related to trading frequency. For portfolios, autocorrelation of returns following a high absolute return day is significantly higher than that following a low absolute return day. Similarly, return autocorrelation during volatile periods is generally larger than that during tranquil periods. Return correlation between weekdays is usually larger than that between the first and last days of the week. Overall, the results suggest that the possible reason for positive autocorrelation in stock returns could be the presence of negative feedback traders who are engaged in frequent profit-taking activities.

Originality/value
This is the first paper that thoroughly investigates the autocorrelation structure of the returns of the Saudi stock market using both index and individual stock returns. As this US$583bn (as of August 21, 2014) market opened to foreign institutional investors in June 2015, the results of this paper should be of significant value for the potential uninformed foreign investors in this relatively lesser known and previously closed yet highly prospective market.
Factors behind support for harsher punishments for common and uncommon offenders
Authors: Palasinski Marek , Shortland Neil 
Published: March 2017

PurposeThe purpose of this paper is to explore individual factors predicting support for harsher punishments for relatively common and uncommon serious offenders.Design/methodology/approachIn Study 1, 120 UK participants (60 males and 60 females; mean age =37.31 SD=16.74) completed a survey exploring the extent to which they supported harsher punishments (SHP) for first time and repeat fraud, sexual and violent offenders. In Study 2, 131 participants (70 Britons and 61 Singaporeans; 69 females and 62 males; mean age=31.57; SD=10.87) completed a similar survey exploring their support for life sentence without the possibility of parole (SLSWP) for rather uncommon repeat offenders (i.e. drug traffickers, human traffickers, serious sexual offenders).FindingsStudy 1 found that right-wing authoritarianism (RWA) was an SHP predictor for first time and repeat fraud, violent and sex offenders. Study 2 found that national identity (i.e. how British or Singaporean participants felt) played a similar role to Study 1’s RWA in being a positive SLSWP predictor for repeat human traffickers and drug traffickers of both sexes, as well as male sex offenders. In contrast to the hypothesis, however, participants’ locations did not appear to play a statistically significant role.Research limitations/implicationsThis survey-based research reveals a nuanced and quite consistent picture that could benefit from the inclusion of socio-economic factors and other cross-cultural comparisons.Practical implicationsThe key message from this study is to inform the public on the role that right-wing authoritarianism and national identity play in their SHP and SLSWP.Social implicationsIt is vital to increase the legislators’ and the public awareness of the role that national identity and RWA seem to play.Originality/valueThe paper offers insight into factors behind people’s punitive attitudes towards specific crimes regardless of geo-cultural location.
More than pictures: developing an accessible resource
Authors: Cameron Lois , Matthews Rhona 
Published: March 2017

Purpose
The purpose of this paper is to describe the process of developing an accessible communication resource which enables people with a learning disability to reflect on their lives and raise issues of concern.

Design/methodology/approach
The process of making the resource and the facets that contribute to making it accessible are explored, e.g. design specification, the relationship between pictures and meaning, the order in which concepts are presented. The paper goes on to describe how the resource is put into practice using the format of a “Talking Mat”.® Talking Mats is a communication framework which has a strong evidence base that shows it improves the quality and quantity of information a person with a learning disability gives in a conversation. It provides practitioners with a consistent framework to support implementation. The impact of using the resource is explored through feedback from practitioners trained to use it and the stories that resulted.

Findings
A well-constructed resource can support people with a learning disability to express their views on what matters to them at a specific time and raise concerns they may have. The individual views that have emerged from people are varied. This resource enabled them to be genuinely included in planning the steps required to bring about positive change in their lives.

Originality/value
There is much emphasis on the development of accessible resources in the field of learning disability but little on the actual development process and the context of how resources are introduced. This paper aims to contribute to this knowledge base.
Retracted: Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles usingPouteria sapotain streptozotocin‐induced diabetic rats
Authors: Prabhu Sathya , Vinodhini Shanmugam , Elanchezhiyan Chakravarthy , Rajeswari Devi 
Published: March 2017

AbstractBackgroundMedicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be good sources of agents effective in the treatment of diabetes mellitus. The present study focused on the green synthesis ofAgNPsfrom the aqueous leaf extract ofPouteria sapotain order to evaluate the in vitro and in vivo antidiabetic properties of this extract and the synthesizedAgNPs.MethodsTheAgNPswere biologically synthesized under ambient conditions from an aqueous leaf extract ofP. sapotausing the hot percolation method and were characterized using spectroscopic methods, X‐ray diffraction, and scanning electron microscopy. The in vitro antidiabetic activity of the aqueous leaf extract andAgNPswas confirmed by non‐enzymatic glycosylation of hemoglobin, glucose uptake by yeast cells following exposure of cells to 5 or 10 mmol/L glucose solution, and inhibition of α‐amylase. Further, in vivo antidiabetic activity was assessed in streptozotocin‐induced rats. Rats were treated with aqueous leaf extract (100 mg/kg) orAgNPs(10 mg/kg) for 28 days. Following treatment, rats were killed for biochemical and histopathological analysis of kidney and liver samples.ResultsA significant reduction in blood sugar levels was noted in rats treated with leaf extract orAgNPs. Results of in vitro and in vivo analyses in rats treated with leaf extract orAgNPsshow that both the extract and the biologically synthesizedAgNPshave antidiabetic activity.ConclusionThe aqueous leaf extract ofP. sapotaandAgNPsexhibited efficient antidiabetic activity in the rat model of diabetes and therefore could have potential for development for medical applications in the future.
Feeding preference as a main determinant of microscale patchiness among terrestrial nematodes
Authors: Quist Casper W. , Gort Gerrit , Mulder Christian , Wilbers Ruud H. P. , Termorshuizen Aad J. , Bakker Jaap , Helder Johannes 
Published: March 2017

AbstractSoil biota are responsible for essential ecosystem services such as carbon storage, nutrient cycling and water retention. However, assessment of the condition of soil biota is hampered by an overwhelming level of diversity. With representatives in all trophic levels of the food web, nematode communities can be used as bioindicators. Accurate assessment of nematode assemblages requires insight into the distribution of specimens with distinct food preferences. With the availability of taxon‐specific quantitative PCR assays, distribution patterns of multiple nematode groups can be investigated simultaneously. Here, microscale patchiness of 45 nematode taxa was studied on 12 sampling sites (each with four adjacent microplots) located on arable fields or semi‐natural grasslands (‘system’), and on marine, river clay or sandy soils (‘soil type’). From each microplot, five composite samples were collected. Contrary to our expectations, an increase in the number of cores per composite sample did not result in more accurate measurements, and apparently the levels of microscale patchiness of the taxa are low compared to what has been reported for oligophagous plant‐parasites. System and soil type did not affect microscale distribution. To investigate the level of patchiness in more detail, detection probability (DP) and variability of abundances were calculated. Common and widespread bacterivorous and fungivorous taxa had DP ≥ 90%, confirming low level of microscale patchiness. With DPs of 40%–70%, predators and most omnivores showed degrees of local clustering. An overview of mean variabilities of abundances is presented that offers insight into how feeding preferences impact the microscale distribution both between and within trophic groups.
Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K‐ras mutation
Authors: Kaseda Kaoru , Asakura Keisuke , Kazama Akio , Ozawa Yukihiko 
Published: March 2017

BackgroundThis study aimed to evaluate mutations of the epidermal growth factor receptor (EGFR) and K‐ras genes and their clinicopathological and prognostic features in patients with resected pathological stage I adenocarcinoma.MethodsWe examined 224 patients with surgically resected lung adenocarcinoma and analyzed the prognostic and predictive value of these mutations in 162 patients with pathological stage I adenocarcinoma.ResultsMutations of the EGFR and K‐ras genes were detected in 100 (44.6%) and 19 (8.5%) of all tumors, and in 81 (50.0%) and 17 (10.5%) of the pathological stage I tumors, respectively. EGFR mutations were significantly associated with female gender, smoking habit (never smoker), and low grade. By contrast, K‐ras mutations were significantly associated with male gender, smoking habit (ever smoker), and the presence of mucinous components. No significant differences were observed in recurrence‐free or overall survival between the EGFR‐mutant, K‐ras‐mutant, and wild‐type groups (five‐year recurrence‐free survival 77.8% vs. 87.8% vs. 79.5%; five‐year overall survival 82.8% vs. 82.4% vs. 79.2%, respectively). Multivariate analysis showed that neither EGFR nor K‐ras mutation was an independent prognostic factor.ConclusionsThe present study demonstrated that pathological stage I adenocarcinoma harboring EGFR and K‐ras gene mutations have distinct clinicopathological features. The presence of these mutations alone were not prognostic factors in patients with resected pathological stage I adenocarcinoma.
Analysis of Blood Flow Characteristics in a Model of a Mature Side‐to‐Side Arteriovenous Fistula
Authors: Javadzadegan Ashkan , Myo Lwin Nay , Asyraf Muhammad , Simmons Anne , Barber Tracie 
Published: March 2017

AbstractThe creation of an arteriovenous fistula (AVF) is a common surgical procedure in hemodialysis patients suffering from end‐stage renal disease (ESRD). However, several complications may occur after surgery, including thrombosis, stenosis, and aneurysm. These complications are attributed to hemodynamics perturbations including pathophysiological wall shear stress (WSS) and flow recirculation zones. In this study, we present a computational hemodynamic analysis in a model of a mature side‐to‐side AVF, which is then validated by experimental measurements. Both computational and experimental results confirmed the presence of complex flow patterns within the AVF with vortices initially developing at the center of the venous region and gradually moving downstream, such that at four characteristic anastomosis lengths downstream, the flow disturbances became minimum. A complex pattern was also observed in WSS distribution with regions of low and high WSS identified in proximal vein and feeding artery, respectively. In addition, the temporal distribution of WSS varied significantly along the venous wall where a large portion of it remained above normal levels of WSS during systole while the area was largely normal during diastole. Our findings support the hypothesis that high WSS is not detrimental to immediate patency of AVF; however, other factors including low WSS and temporal and spatial gradients of WSS increase the risk of vascular access complications.
Letter: dose optimising infliximab in acute severe ulcerative colitis
Authors: Choy M. C. , De Cruz P. 
Published: March 2017

Linked ContentThis article is linked to Jairath et al and Hindryckx et al papers. To view these articles visit https://doi.org/10.1111/apt.14019 and https://doi.org/10.1111/apt.13913.
Editorial: co‐existing immune‐mediated disease in inflammatory bowel diseases – a new disease severity indicator?
Authors: Vegh Z. , Bessissow T. , Afif W. , Lakatos P. L. 
Published: March 2017

Linked ContentThis article is linked to Ananthakrishnan and Conway et al papers. To view these articles visit https://doi.org/10.1111/apt.13998 and https://doi.org/10.1111/apt.13940.
Editorial: scoring systems in primary biliary cholangitis – time to make a move. Authors’ reply
Authors: Yang F. , Yang Y. , Tang R. , Gershwin M. E. , Ma X. 
Published: March 2017

Linked ContentThis article is linked to Mells and Jones and Yang et al papers. To view these articles visit https://doi.org/10.1111/apt.13984 and https://doi.org/10.1111/apt.13927.
Functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort
Authors: Wauters L. , Nightingale S. , Talley N. J. , Sulaiman B. , Walker M. M. 
Published: March 2017

SummaryBackgroundThe pathophysiology of functional dyspepsia (FD) remains unknown. Duodenal eosinophil infiltration has been reported.AimTo assess the association between dyspeptic symptoms and duodenal eosinophilia in children undergoing upper gastrointestinal endoscopy.MethodsIn this retrospective cohort study, children with normal upper endoscopy and routine histology at a single tertiary paediatric centre between 2010 and 2014 were included. FD was defined as epigastric pain or discomfort >2 months without response to acid suppression. Controls presented with nonerosive reflux disease, dysphagia or rumination syndrome. Intramucosal eosinophil counts were compared between the groups using uni‐ and multivariate regression analyses.ResultsThirty‐six cases and 36 nonmatched controls were identified. Atopic history (39% vs. 25%) and psychological comorbidity (53% vs. 39%; both P = 0.2) were frequent in cases and controls. Self‐reported nausea (64% vs. 17%; P < 0.0001), lethargy (19% vs. 0%; P = 0.005) and family functional gastrointestinal disorder(FGID) (28% vs. 3%; P = 0.003) were more common in cases than controls. Duodenal eosinophil counts [median (IQR): 151 (118–207) vs. 76 (60–106) per mm2; P < 0.001] were significantly higher in cases than controls with >112 eosinophils per mm2 predictive for FD (OR: 33.6, 95% CI: 7.1–159.0; P < 0.001). Duodenal eosinophilia was associated with weight loss (OR: 7.1, 95% CI: 1.1–45.5; P = 0.04).ConclusionsFunctional dyspepsia in children is strongly associated with duodenal eosinophilia, in the absence of endoscopic or routine histological findings. Frequent atopic and psychological comorbidity illustrate likely multifactorial mechanisms.
Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants
Authors: Stolk Leo M. , de Vries Frank , Ebbelaar Chiel , de Boer Anthonius , Schalekamp Tom , Souverein Patrick , ten Cate‐Hoek Arina , Burden Andrea M. 
Published: March 2017

AimDirect‐acting oral anticoagulants (DOACs) have become available for the prevention of stroke in patients with atrial fibrillation (AF). Conflicting results have been published on the risk of acute myocardial infarction (AMI) with the use of DOACs in comparison with vitamin K antagonists (VKAs). The objective of the present study was to evaluate the risk of AMI in patients with AF who are exposed to either VKAs, DOACs or low‐dose (< 325 mg) aspirin.MethodsWe conducted a population‐based cohort study using data from the Clinical Practice Research Datalink (2008–2014). The study population (n = 30 146) consisted of all patients ≥18 years with a diagnosis of AF who were new users of VKAs, DOACs (rivaroxaban and dabigatran) or aspirin. Cox proportional hazards models were used to estimate the hazard ratio (HR) of AMI for users of DOACs or aspirin vs. VKA. Adjustments were made for age, gender, lifestyle, risk factors, comorbidity and other drugs.ResultsThe risk of AMI was doubled when we compared current use of DOACs with current use of VKAs [adjusted HR 2.11; 95% confidence interval (CI) 1.08, 4.12] and for current users of aspirin vs. current VKA users (adjusted HR 1.91; 95% CI 1.45, 2.51).ConclusionsThere is a twofold increase in the risk of AMI for users of DOACs, in comparison with VKAs, in AF therapy. In addition, the results suggested that in patients with AF, the incidence of AMI is higher during aspirin monotherapy than during the use of VKAs.