bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical Analysis of Key Anticancer Herbal Drugs: Progress and Innovations in Emodin, Rutin, Berberine, Shikonin, and Sophoridine
Authors: Zheng Yuhong , Fu Li , Zhu Jiangwei , Han Fugui 
Published: September 2024

Background:
Anticancer herbal drugs have gained significant attention in pharmaceutical
research due to their complex chemical profiles and multifaceted therapeutic effects. Electrochemical
analysis has emerged as a powerful tool for studying these compounds, offering unique
insights into their behavior and properties.

Methods:
This review examines recent advances in the electrochemical analysis of five key anticancer
herbal drugs: emodin, rutin, berberine, shikonin, and sophoridine. Various electrochemical
techniques, including cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry,
are discussed in relation to their application in detecting and characterizing these compounds.

Results:
Significant progress has been made in developing highly sensitive and selective electrochemical
sensors for these herbal drugs. Nanomaterial-modified electrodes have consistently improved
detection limits and expanded linear ranges. Compound-specific innovations in electrode
modifications and measurement techniques have been tailored to the unique electrochemical properties
of each drug.

Conclusion:
Electrochemical analysis of anticancer herbal drugs has advanced substantially, offering
powerful tools for studying and utilizing these compounds in cancer research and treatment. Future
directions include the development of multi-analyte sensors, integration with microfluidic technologies,
and application of artificial intelligence for data analysis. Challenges remain in improving
the stability of modified electrodes and standardizing protocols for sample preparation and analysis.
A Toluene-induced Infundibulo-neuro-hypophysitis: Presentation of a New Cause of Hypophysitis Secondary to Toxic Exposure and Review on Toluene Inhalation Endocrine Effects
Authors: Costanza Flavia , Giampietro Antonella , Tartaglione Tommaso , Angelini Flavia , Gaudino Simona , De Marinis Laura , Pontecorvi Alfredo , Chiloiro Sabrina , Bianchi Antonio 
Published: September 2024

Introduction:
Hypophysitis is a rare inflammatory disorder of the pituitary gland.
Symptoms and signs of hypophysitis can be various, progressing insidiously, and its recognition
may be challenging.

Case Presentation:
We report the clinical history and therapeutic management of a 59-year-old
man diagnosed with arginine vasopressin deficiency (AVP-D) due to an infundibulo-neurohypophysitis
(INH) that occurred after the patient had inhaled spray film containing toluene. In
consideration of the clinical signs and radiological imaging suggestive of INH, therapy with
desmopressin and corticosteroids was instituted, with gradual improvement of polyuria and resolution
of the radiological features of INH.

Conclusion:
To our knowledge, we described the first case of INH, manifested with AVP-D,
secondary to toluene exposure. In addition, the endocrine effects of toluene inhalation were discussed.
Finally, given the scarcity of data available, an overview of all the known toxic substances
inducing AVP-D was also provided.
Design and in vitro Evaluation of Cocoa Butter-based Amlodipine Besylate Fast Melt Tablets
Authors: Janakiraman Ashok Kumar , Ong Khai Kee , Sundarapandian Ramkanth , Liew Kai Bin , Kayarohanam Saminathan , Zenli Cheng , Saleem Mohamed 
Published: September 2024

Background:
Oral fast-melting tablets (FMTs) have been gaining popularity due to
their advantages in resolving swallowing issues of conventional oral tablets. Cocoa butter is an excipient
of choice to develop FMT with an acceptable taste and faster onset of action of the drug.

Purpose:
The present study aimed to prepare and characterize the amlodipine besylate-loaded cocoa
butter FMTs.

objective:
To prepare and characterise the formulation of cocoa butter tablet as fast melt buccal delivery system of amlodipine besylate.

Method:
Amlodipine besylate FMTs were prepared using a simple freezing (refrigeration)
method. Cocoa butter (Form V) was used as the base to achieve a final tablet weight of 500 mg
with drug and other functional excipients. The designed prototype tablet formulations were subjected
to disintegration tests to determine the robust selected batch. The formulation F4, containing
7% high-molecular-weight chitosan, exhibited the quickest disintegration time of 1.45 ± 0.10
min. Afterwards, the selected formulation, F4, was subjected to quality evaluation parameters.

Results:
Fourier transform infrared spectroscopy (FTIR) studies revealed that there was no incompatibility
between amlodipine besylate, cocoa butter, and other excipients. The average hardness
of the F4 formulation tablet batch was found to be 2.69 ± 0.21 kg/cm2 and a friability of less than
1%. The drug content in F4 tablets was found to be 102.38 ± 5.29% and showed an in-vitro drug
release of 94.30 ± 2.63% within 30 min. Over a six-month stability testing period, the chosen F4
formulation did not significantly change in terms of tablet average weight, disintegration time,
drug content, and in-vitro dissolution rate.

Conclusions:
Selected formulation F4 with 7% of high molecular weight chitosan exhibited good
physical properties, indicating the suitability of cocoa butter as a base to produce FMTs with the
aid of a natural super-disintegrant.
Ethanolic Extract Clove-loaded Chitosan Nanoparticles Reduce Dyslipidemia, Enhance Liver and Kidney Functions, and Improve the Antioxidant System in Obese Rats
Authors: Abelsalam Yasmine Gamal Salah , Mohamed Hanan Ramadan H. , Baiomy Ahmed Abdel Aziz , Abdelfattah Marwa Ahmed , Mohamed Ayman Saber 
Published: September 2024

Background:
Obesity, a chronic low-grade inflammatory disease characterized by multiple
metabolic dysfunctions, poses a considerable worldwide health risk to adults and children.
Clove has also shown that it possesses anti-inflammatory, anti-fungal, antibacterial, antioxidant,
antiglycation, and anti-aging properties.

Aim:
The current study aimed to investigate the antiobesity effect of clove-loaded chitosan nanoparticles
in obese rats.

objective:
The current study investigated the antiobesity effect of clove-loaded chitosan nanoparticles in obese rats.

Method:
Obesity is induced in rats by the administration of a High-Fat Diet (HFD) for 4 weeks.
24 rats were divided into 4 groups; Control group, in which rats were fed normal; HDF group, in
which rats were HFD along with distilled water; HFD + empty nanoparticles (ENPs), in which
rats were HFD along with ENPs (45 mg/kg); and HFD + clove nanoparticles (CNPs), in which
rats were HFD along with CNPs (45 mg/kg) for four weeks.

Results:
Administration of ENPs and CNPs led to a notable reduction in glucose, aminotransferases,
alkaline phosphatase, cholesterol, triglycerides, low-density lipoproteins, malondialdehyde, nitric
oxide, caspase-3, PCNA, leptin, and DNA fragmentation. Additionally, it promoted an increase
in total proteins, albumin, high-density lipoprotein, glutathione, catalase, and adiponectin.
Also, the histopathological investigation of the liver and kidney showed the protective effect of
ENPs and CNPs on the tissues of obese rats.

Conclusion:
The present investigation elucidated the preventive effects of chitosan nanoparticles
loaded with clove on dyslipidemia in obese rats. Clove nanoparticles exhibited hypolipidemia, antioxidant,
hypoglycemia, and hepatoprotective activities.
FORMULASI GLUTEN FREE COOKIES DARI TEPUNG PISANG KEPOK, TEPUNG KULIT PISANG KEPOK (Musa paradisiaca) (Blanching dan Non-Blanching) DENGAN PENAMBAHAN TEPUNG KACANG ALMOND (Prunus dulcis)
Authors: Samsoedin Fadhila Marwa , Saati Elfi Anis , Anggriani Rista 
Published: September 2024

Pangan bebas gluten disasarkan kepada penyandang intolerant gluten harus mempertimbangkan bahan pangan yang digunakan. Pemanfaatan produk lokal seperti tepung pisang kepok, tepung kulit pisang dan tepung almond yang termasuk tepung gluten free. Oleh karena itu, pengembangan tepung-tepungan perlu dilakukan agar bermanfaat bagi manusia sebagai bahan pangan campuran atau substitusi pada makanan salah satunya pembuatan cookies. 6
Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) Sederhana. Terdapat 9 taraf perlakuan serta terdiri dari tiga ulangan. Parameter pengamatan meliputi kadar air, kadar abu, kadar lemak, kadar protein, karbohidrat, serat kasar uji hedonik organoleptik dan perlakuan terbaik. Setiap data yang diperoleh serta diolah menggunakan analisis ragam (ANOVA) pada α = 5%. Apabila berpengaruh nyata maka data yang diperoleh dilanjutkan dengan uji pembeda menggunakan uji DMRT (Duncan Multiplerange Test).
Hasil penelitian menunjukkan bahwa tingkat tepung pisang kepok, tepung kulit pisang kepok dan tepung almond berpengaruh sangat nyata terhadap kadar air, kadar protein, karbohidrat, serat kasar, tekstur, warna (kenampakan), aroma, rasa dan kesukaan. Berdasarkan penilaian perlakuan terbaik dengan nilai organoleptik yang disukai didapatkan pada formulasi F4 dengan perbandingan 60% Tepung Pisang Kepok:30% Tepung Kulit Pisang Kepok:10% Tepung Almond. Sedangkan untuk produk terbaik dengan nilai serat kasar tertinggi pada formulasi F8 (60% Tepung Pisang Kepok:30%Tepung Kulit Pisang (Blanching):10% Tepung Almond )
ANALISIS KELAYAKAN USAHA PADA PRODUK MAKANAN RINGAN OAT COOKIES “OKUKKI”
Authors: Rahmadani Yesika , Saati Elfi Anis , Anggriani Rista 
Published: September 2024

Seiring dengan perkembangan zaman seperti di era modern saat ini mulai banyak dikembangkan berbagai macam produk pangan dengan membuat modifikasi terbaru agar dapat disesuaikan dengan pola konsumsi masyarakat. Aktivitas yang cukup padat membuat masyarakat cenderung mengonsumsi makanan yang praktis dan instan. Salah satu contoh produk pangan yang mulai dikembangkan dan dimodifikasi yaitu produk cookies. Tujuan dari penelitian ini yaitu untuk menganalisis kelayakan usaha Oat Cookies “OKUKKI” meliputi Break Even Point (BEP), Revenue/Cost (R/C), Return of Investment (ROI), Payback Period (PP). Hasil analisis bisnis Oat Cookies “OKUKKI” layak untuk dikembangkan karena R/C > 1 yaitu 1,28 maka usaha yang dijalankan mengalami keuntungan. Break Even Point (BEP) titik impas ketika dapat menjual sebanyak 85 unit/bulan dengan harga sebesar Rp.12.000/porsi menghasilkan omset sebesar Rp.698.129/bulan. Return On Investment (ROI) sebesar 28,5% keuntungan dari besarnya modal yang dikeluarkan selama 1 tahun. Payback Periode (PP) jangka waktu pengembalian modal usaha Oat Cookies “OKUKKI” yaitu kurang dari 1 tahun, yakni 3 sampai 4 bulan.
PENGEMBANGAN APLIKASI MOBILE RESERVASI BERBASIS WEB UNTUK MENINGKATKAN SOCIOPRENEUR DI WISATA GLAMPING GUBUG MARAWATI DESA SAJEN
Authors: Ramadhani Nugrahardi , Prasetyo Didit , Yudistira Alamin Rabendra , Noordyanto Naufan , Dwitasari Putri , Orta Darmawati Nurina , Kusuma Wardani Kartika , Dharmawan Yogantara S. , Jati Santoso Bagus 
Published: September 2024

Peningkatan minat terhadap wisata glamping di Indonesia menuntut adanya inovasi dalam sistem reservasi yang efisien dan user-friendly. Pengabdian masyarakat ini bertujuan untuk mengembangkan aplikasi mobile reservasi berbasis web dan mensosialisasikan agar membantu meningkatkan layanan dan mengembangkan sociopreneur di Wisata Glamping Gubug Marawati. Metode yang digunakan meliputi survei kepada pengguna aplikasi reservasi mobile dengan fokus pada demografi, preferensi fitur, pengalaman pemesanan, dan masalah teknis. Hasil menunjukkan bahwa mayoritas responden berusia 25-35 tahun dengan pendidikan minimal S1 dan memiliki pekerjaan tetap, menginginkan aplikasi yang user-friendly dan mudah diakses. Fitur pencarian informasi, pemesanan online, dan ulasan pengguna paling diminati, sementara integrasi dengan sistem pembayaran digital dan fitur notifikasi dianggap penting. Pengalaman pengguna cukup positif, namun ada keluhan terkait waktu loading dan kegagalan transaksi. Masalah teknis seperti bug dan crash juga sering ditemukan. Kesimpulan menunjukkan bahwa aplikasi mobile yang stabil, responsif, dan informatif dengan dukungan teknis non-stop sangat diperlukan untuk memenuhi kebutuhan pengguna dan mendukung tujuan Sustainable Development Goals (SDGs) dalam meningkatkan kualitas layanan wisata berbasis alam dan mendukung kewirausahaan sosial di daerah tersebut.
Prevalence, prognosis, and health care resource utilization in carriers of pathogenic germline variants in BRCA1/2 with incident early-stage breast cancer: a Finnish population-based study
Authors: Karihtala Peeter , Laatikainen Outi , Tuominen Samuli , Ågesen Trude , Eliasen Rasmus 
Published: September 2024

Background and purpose: Data on real-world prevalence and outcomes in patients diagnosed with pathogenic germline variants in BRCA1 or BRCA2 (gBRCAm) breast cancer is sparse.
Material and methods: An observational cohort study including all patients diagnosed with incident early-stage breast cancer and recorded in Helsinki University Hospital data lake 2012–2022, accounting for one-third of the Finnish breast cancer patient population.
Results: Among 14,696 incident early-stage breast cancer patients, 11.2% (n = 1,644) were tested for gBRCAm. Of the tested population, 7.4% (n = 122) carried gBRCAm. Of the 122 gBRCAm patients, 95.1% (n = 116) were women, with a median age at diagnosis of 46.4 years. Among the same patient group, HER2 status was available for 87.7% (n = 107) of the patients. Among these, 49.5% (n = 53) had hormone receptor-positive (HR+), HER2-negative breast cancer, 13.1% were (n = 14) HER2-positive, and 37.3% (n = 40) of patients had triple-negative breast cancer. The tested patients were significantly younger compared with non-tested patients. No significant differences in overall survival or healthcare resource utilization between the tested patients with gBRCAm and gBRCA wild-type (gBRCAwt) were observed.
Interpretation: This comprehensive observational study supports previous findings of gBRCAm prevalence in the Western early-stage breast cancer population. While no differences in survival were observed between patients with gBRCAm and gBRCAwt, it is important to consider the potential influence of selection bias, particularly due to the younger gBRCAm testing target population and the overall low frequency of testing. Therefore, a substantial proportion of the patients carrying gBRCAm likely remained undiagnosed, and wider screening criteria are warranted.
Analisis Faktor Risiko Asfiksia Neonatorum di RSUD Labuang Baji Makassar Tahun 2021
Authors: Shanun Shari Sakunti  , Rini Fitriani  , Syatirah Jalaluddin  , Andi Tihardimanto  
Published: September 2024

Asfiksia merupakan penyebab kedua terbanyak kematian neonatal di Indonesia pada tahun 2019 dengan kasus sebanyak 5.464 kasus. Asfiksia terjadi karena kurangnya aliran darah ataupun pertukaran gas dari atau ke janin pada bayi baru lahir. Jika keadaan ini tidak ditangani secara cepat dan tepat maka dapat menyebakan kerusakan organ vital. Tujuan penelitian ini untuk mengetahui faktor risiko yang mempengaruhi kejadian asfiksia neonatorum di RSUD Labuang Baji Makassar. Desain penelitian yang digunakan yaitu analitik observasional dengan pendekatan case control. Pengambilan sampel dilakukan dengan teknik purposive sampling dengan menggunakan data sekunder berupa rekam medik pasien. Dari sampel 47 kasus dan 47 kontrol dengan uji chi square odd rasio didapatkan ibu dengan anemia, Ibu dengan Ketuban Pecah Dini (KPD), Berat Badan Lahir Rendah (BBLR) dan usia gestasi merupakan faktor resiko terjadinya kejadian asfiksia neonatorum di RSUD Labuang Baji Makassar Tahun 2021 dengan hasil yang signifikan P-Value ≤ 0,05 dan masing-masing nilai OR 3,410; 3,872; 7,451; 7,765.
Avaliação funcional de pacientes com Acidente Vascular Encefálico em uma cidade do Estado do Pará
Authors: Moreira Neto Adalberto Alves , Andrade Carolina Leão Menezes , Muniz José Robertto Bueno , Ruiz Julia Alves , Barros Larissa Navarro , Luz Maíra Fontel da , Veloso Renato de Andrade , Machado Giovanna Santana , Soares Romária Emanuela Carvalho Santos , Pinto Maria Joana da Silva 
Published: September 2024

Objetivo: Delinear a capacidade funcional dos pacientes com acidente vascular encefálico atendidos em ambulatório de neurologia, possibilitando a verificação das principais incapacidades existentes e possíveis complicações para o cotidiano dos questionados e de seus familiares. Métodos: Este é um estudo transversal, unicêntrico e vale-se de critérios quantitativos, com 20 pacientes selecionados como amostra. A amostragem foi submetida à aplicação do Índice de Barthel (IB) e à Escala de Lawton (EL), ambas escalas que avaliam a capacidade funcional de pacientes com doenças crônicas incapacitantes. Resultados: O IB acusou dependência geral moderada e maior comprometimento de funções relativas à mobilidade dos pacientes, enquanto o EL demonstra dependência parcial e total em 25% e 70% dos pacientes, respectivamente, com predomínio da ausência de autonomia pessoal quando se questiona a capacidade de “Organização de casa”. Sabe-se que as Atividades Básicas da Vida Diária e Atividades Instrumentais da Vida Diária compõem a avaliação da capacidade funcional de pacientes em situação de sequelas, demonstrando neste, graves entraves físicos e emocionais para os pacientes e seus familiares. Conclusão: Foi possível descrever as principais limitações encontradas no cotidiano dos pacientes avaliados, suscitando o desenvolvimento de políticas públicas que favoreçam o bem-estar dessa população.
Оториноларингологические аспекты переломов височной кости
Authors: Dvorianchikov V.V. , Kuzenkova A.I. , Golovanov A.E. , Korovin P.A. , Vostrikova E.V. , Kireev P.V. , Khamgushkeeva N.N. 
Published: September 2024

Traumatic temporal bone injury can have significant consequences, and knowledge of the relevant anatomy, pathophysiology of the injury, and early referral to specialists is crucial for successful recovery and rehabilitation of these patients. The traditional classification of temporal bone fractures includes longitudinal, transverse, combined, and anterior skull base fractures. The most common complications of temporal bone fractures are damage to the facial nerve, cerebrospinal fluid leakage, and hearing loss. Symptoms include dizziness, nystagmus toward the intact temporal bone, and mixed hearing loss on the affected side. The manifestation of traumatic facial nerve injury is paresis and/or paralysis of the facial muscles. This symptom occurs in 30-50% of cases in transverse temporal bone fracture, and in 10-25% of cases in longitudinal temporal bone fracture. Untimely diagnosis of concomitant disease in relation to the underlying disease may lead to longer and more costly treatment and rehabilitation of the patient in the future. We present a review and describe a clinical case of neurotrauma resulting from temporal bone fracture from an otorhinolaryngologic point of view. The main symptoms are described, and a clinical case of surgical treatment of a closed compression fracture of the temporal bone with dislocation and facial nerve injury is presented.
Травматическое повреждение височной кости (ВК) может привести к серьезным последствиям, и знание соответствующей анатомии, патофизиологии травмы и раннее привлечение специалистов смежных специальностей имеет решающее значение для успешного лечения и реабилитации данной категории пациентов. В литературе широко распространена т.н. «традиционная» классификация переломов ВК, согласно которой различают продольные, поперечные, комбинированные переломы и переломы передних отделов основания черепа. Наиболее частыми осложнениями переломов ВК являются повреждение лицевого нерва (ЛН), истечение спинномозговой жидкости и снижение слуха. Из симптомов наблюдаются также головокружение, нистагм в сторону неповрежденной ВК и снижение слуха на пораженной стороне по смешанному механизму. Проявлением травматического повреждения ЛН являются парез и/или паралич мимической мускулатуры. При поперечном переломе ВК данный симптом обнаруживается в 30–50% случаев и в 10–25% случаев продольных переломов ВК. Несвоевременная диагностика сопутствующей по отношению к основному заболеванию патологии может привести к более длительному и дорогостоящему лечению и реабилитации пациента в будущем. В данной статье представлен обзор литературы и клинический случай при нейротравме вследствие перелома ВК, с точки зрения оториноларинголога. Описаны основные клинические симптомы, возникающие при переломах ВК. Представлен опыт хирургического лечения закрытого оскольчатого перелома ВК со смещением костных отломков и развитием пареза мимической мускулатуры.
Влияние вегетативной нервной системы на функции носа и околоносовых пазух в норме и патологии
Authors: Elizbaryan I.S. , Lazareva L.A. , Kumbatov T.P. , Azamatova S.A. , Kovalenko S.L. 
Published: September 2024

A review of scientific publications on anatomical, morphophysiological and functional interactions of the functions of the nose and paranasal sinuses and the autonomic nervous system (ANS) is presented. Both the physiological processes of the direct (physiological) influence of the ANS and the effect of pathological inflammatory processes in the nasal cavity and adjacent areas on the central parts of the autonomic nervous system are analyzed. A literary search was carried out on the databases Medline, PubMed, Scopus, CyberLeninka; the electronic catalog of the publishing houses Elsevier, Springer Medicine, Biomed Central, Media Sphere was also used; scientific electronic library
Представлен обзор научных публикаций по анатомо-морфофизиологическим и функциональным взаимодействиям функции носа и околоносовых пазух и вегетативной нервной системы (ВНС). Проанализированы как физиологические процессы прямого (физиологического) влияния ВНС, так и воздействие патологических воспалительных процессов в полости носа и прилегающих областях на центральные ГОЛОВА И ШЕЯ РОССИЙСКИЙ ЖУРНАЛ Том 12, №1 – 2024 122 ОБЗОРЫ ЛИТЕРАТУРЫ отделы ВНС. Литературный поиск проведен по базам данных Medline, PubMed, Scopus, КиберЛенинка, также использован электронный каталог издательств Elsevier, Springer Medicine, Biomed Central, Медиа Сфера, научная электронная библиотека
Study of operational observation spacecraft maneuvers
Authors: Буксар М.Ю. , Ермолаев В.И. 
Published: September 2024

Рассмотрены манёвры оперативного изменения режима и района наблюдения космическими аппаратами оперативного наблюдения. Разработаны математические модели и определены области рационального использования предложенных способов маневрирования
The maneuvers of the operative changing of the observation mode and area by operational observation spacecraft were considered in this article. The mathematical models of suggested methods were developed. The areas of rational use of suggested methods were determined
Space-borne electro-optical surveillance systems between past and future. Part 2. Analysis of capabilities of present constellation of foreign military surveillance satellites
Authors: Клименко Н.Н. , Занин К.А. 
Published: September 2024

Рассматриваются особенности орбитального построения современной орбитальной группировка космических аппаратов оптико-электронного наблюдения KeyHole с учётом задач формирования эталонов для автоматического распознавания объектов, оперативного слежения за обстановкой, площадной съёмки и формирования базы геопространственной информации. Проведена оценка основных показателей эффективности: периодичности и пространственной разрешающей способности. Проведён анализ дальнейших экспериментальных направлений развития гибридной космической системы наблюдения
The features of deployment of present constellation of Keyhole electro-optical surveillance satellites are considered with regard to the tasks of reference image accumulation for automatic target recognition, situational awareness monitoring, synoptic area imaging and geospatial database creation. Evaluation of basic performance indicators – revisit time and spatial resolution – is produced. Analysis of further experimental advancement trends was carried out