bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathologic significance of MYD88 L265P mutation in diffuse large B-cell lymphoma: a meta-analysis
Authors: Lee Ju-Han , Jeong Hoiseon , Choi Jung-Woo , Oh HwaEun , Kim Young-Sik 
Published: May 2017

AbstractThe precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 published studies on 2736 DLBCL patients. We collected relevant published research findings identified using the PubMed and Embase databases. The effect sizes of outcome parameters were calculated using a random-effects model. In this meta-analysis, the MYD88 L265P mutation in DLBCL showed a significant difference according to tumor sites. The overall incidence of the MYD88 L265P mutation in DLBCLs, excluding the central nervous system and testicular DLBCLs, was 16.5%. Notably, the MYD88 L265P mutation rates of CNS and testicular DLBCL patients were 60% and 77%, respectively. Interestingly, the MYD88 L265P mutation was more frequently detected in activated B-cell-like (ABC) or non-germinal center B-cell-like (GCB) than GCB subtype (OR = 3.414, p < 0.001). The MYD88 L265P mutation was significantly associated with old age and poor overall survival, but not with sex and clinical stage. This pooled analysis demonstrates that the MYD88 L265P mutation is significantly associated with the tumor sites and molecular subtypes in DLBCL patients.
A randomized comparison of the prone ventilation endotracheal tube versus the traditional endotracheal tube in adult patients undergoing prone position surgery
Authors: Zou Wangyuan , Shao Jiali , Liang Xia , Li Lin , He Zhenghua , Guo Qulian 
Published: May 2017

AbstractEndotracheal tube displacement or dislocation is a severe complication that can occur in patients who require prone position ventilation. We hypothesized the prone position tube (PPT) would reduce the incidence of displacement of an endotracheal tube in an adult prone operation compared to a traditional tube (TT). A total of 80 adult patients undergoing neurosurgery or spine surgery were recruited. Sixty patients with prone position ventilation were randomly divided into the traditional routine endotracheal tube group (Group TT, n = 30) and the prone position ventilation endotracheal tube group (Group PPT, n = 30). The primary outcome measures were the incidence of the endotracheal tube displacement during surgery, and the secondary outcomes were symptoms of sore throat, dysphagia and dysphonia during follow-up in the post-anesthesia care unit (PACU). The incidence of tube displacement was significantly lower in the PPT group (0 [0%] of 30 patients) compared to the TT group (22 [73.3%] of 30 patients; odds ratio [OR] 0.73, 95% CI 0.591–0.910; P = 0.005). There was no statistical difference in sore throat, dysphagia and vocal function between the two groups (P > 0.05) during follow-up. Compared to the traditional tube, the improved prone positon tube reduced the incidence of displacement of the endotracheal tube. This study was registered with ClinicalTrials.gov on April 29, 2015 (No. NCT02449356).
Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice
Authors: Ennequin Gaël , Capel Frederic , Caillaud Kevin , Chavanelle Vivien , Etienne Monique , Teixeira Allison , Li Xinyan , Boisseau Nathalie , Sirvent Pascal 
Published: May 2017

AbstractIt has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57BL/6JRJ healthy controls. NRG1 treatment improved complex 2-mediated mitochondrial respiration in the gastrocnemius of both control and diabetic mice and increased mitochondrial complex 2 subunit content by 2-fold. This effect was not associated with an increase in mitochondrial biogenesis markers. Enhanced ERBB4 phosphorylation could mediate NRG1 effects on mitochondrial function through signalling pathways, independently of ERK1/2, AKT or AMPK.
Off-Stoichiometry Driven Carrier Density Variation at the Interface of LaAlO3/SrTiO3
Authors: Tsai Ming-Shiu , Li Chi-Sheng , Guo Shih-Ting , Song Ming-Yuan , Singh Akhilesh Kr. , Lee Wei-Li , Chu M.-W. 
Published: May 2017

AbstractThe interface between LaAlO3 (LAO) and SrTiO3 (STO) has attracted enormous interests due to its rich physical phenomena, such as metallic nature, magnetism and superconductivity. In this work, we report our experimental investigations on the influence of the LAO stoichiometry to the metallic interface. Taking advantage of the oxide molecular beam epitaxy (MBE) technique, a series of high quality LAO films with different nominal La/Al ratios and LAO thicknesses were grown on the TiO2-terminated STO substrates, where systematic variations of the LAO lattice constant and transport property were observed. In particular, the sheet density can be largely reduced by nearly an order of magnitude with merely about 20% increase in the nominal La/Al ratio. Our finding provides an effective method on tuning the electron density of the two-dimensional electron liquid (2DEL) at the LAO/STO interface.
The emerging role of NADPH oxidase NOX5 in vascular disease
Authors: Jha Jay C. , Watson Anna M.D. , Mathew Geetha , de Vos Lisanne C. , Jandeleit-Dahm Karin 
Published: May 2017

Oxidative stress is a consequence of up-regulation of pro-oxidant enzyme-induced reactive oxygen species (ROS) production and concomitant depletion of antioxidants. Elevated levels of ROS act as an intermediate and are the common denominator for various diseases including diabetes-associated macro-/micro-vascular complications and hypertension. A range of enzymes are capable of generating ROS, but the pro-oxidant enzyme family, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), are the only enzymes known to be solely dedicated to ROS generation in the vascular tissues, kidney, aortas and eyes. While there is convincing evidence for a role of NOX1 in vascular and eye disease and for NOX4 in renal injury, the role of NOX5 in disease is less clear. Although NOX5 is highly up-regulated in humans in disease, it is absent in rodents. Thus, so far it has not been possible to study NOX5 in traditional mouse or rat models of disease. In the present review, we summarize and critically analyse the emerging evidence for a pathophysiological role of NOX5 in disease including the expression, regulation and molecular and cellular mechanisms which have been demonstrated to be involved in NOX5 activation.
Developing the Alphabetic Principle to Aid Text-Based Augmentative and Alternative Communication Use by Adults With Low Speech Intelligibility and Intellectual Disabilities
Authors: Schmidt-Naylor Anna C. , Saunders Kathryn J. , Brady Nancy C. 
Published: May 2017

PurposeWe explored alphabet supplementation as an augmentative and alternative communication strategy for adults with minimal literacy. Study 1's goal was to teach onset-letter selection with spoken words and assess generalization to untaught words, demonstrating the alphabetic principle. Study 2 incorporated alphabet supplementation within a naming task and then assessed effects on speech intelligibility.MethodThree men with intellectual disabilities (ID) and low speech intelligibility participated. Study 1 used a multiple-probe design, across three 20-word sets, to show that our computer-based training improved onset-letter selection. We also probed generalization to untrained words. Study 2 taught onset-letter selection for 30 new words chosen for functionality. Five listeners transcribed speech samples of the 30 words in 2 conditions: speech only and speech with alphabet supplementation.ResultsAcross studies 1 and 2, participants demonstrated onset-letter selection for at least 90 words. Study 1 showed evidence of the alphabetic principle for some but not all word sets. In study 2, participants readily used alphabet supplementation, enabling listeners to understand twice as many words.ConclusionsThis is the first demonstration of alphabet supplementation in individuals with ID and minimal literacy. The large number of words learned holds promise both for improving communication and providing a foundation for improved literacy.
A Comparison of the Metalinguistic Performance and Spelling Development of Children With Inconsistent Speech Sound Disorder and Their Age-Matched and Reading-Matched Peers
Authors: McNeill Brigid C. , Wolter Julie , Gillon Gail T. 
Published: May 2017

Purpose
This study explored the specific nature of a spelling impairment in children with speech sound disorder (SSD) in relation to metalinguistic predictors of spelling development.

Method

The metalinguistic (phoneme, morphological, and orthographic awareness) and spelling development of 28 children ages 6–8 years with a history of inconsistent SSD were compared to those of their age-matched (
n
= 28) and reading-matched (
n
= 28) peers. Analysis of the literacy outcomes of children within the cohort with persistent (
n
= 18) versus resolved (
n
= 10) SSD was also conducted.

Results
The age-matched peers outperformed the SSD group on all measures. Children with SSD performed comparably to their reading-matched peers on metalinguistic measures but exhibited lower spelling scores. Children with persistent SSD generally had less favorable outcomes than children with resolved SSD; however, even children with resolved SSD performed poorly on normative spelling measures.

Conclusion
Children with SSD have a specific difficulty with spelling that is not commensurate with their metalinguistic and reading ability. Although low metalinguistic awareness appears to inhibit these children's spelling development, other factors should be considered, such as nonverbal rehearsal during spelling attempts and motoric ability. Integration of speech-production and spelling-intervention goals is important to enhance literacy outcomes for this group.
Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms
Authors: Mack Jennifer E. , Thompson Cynthia K. 
Published: May 2017

Purpose
The present study tested whether (and how) language treatment changed online sentence processing in individuals with aphasia.

Method

Participants with aphasia (
n
= 10) received a 12-week program of Treatment of Underlying Forms (Thompson & Shapiro, 2005) focused on production and comprehension of passive sentences. Before and after treatment, participants performed a sentence-picture matching task with active and passive sentences as eye movements were tracked. Twelve age-matched controls also performed the task once each.

Results
In the age-matched group, eye movements indicated agent-first predictive processing after hearing the subject noun, followed by rapid thematic reanalysis after hearing the verb form. Pretreatment eye movements in the participants with aphasia showed no predictive agent-first processing, and more accurate thematic analysis in active compared to passive sentences. After treatment, which resulted in improved offline passive sentence production and comprehension, participants were more likely to respond correctly when they made agent-first eye movements early in the sentence, showed equally reliable thematic analysis in active and passive sentences, and were less likely to use a spatially based alternative response strategy.

Conclusions
These findings suggest that treatment focused on improving sentence production and comprehension supports the emergence of more normal-like sentence comprehension processes.
High Risk Factors Associated With Early Childhood Hearing Loss: A 3-Year Review
Authors: Dumanch Kelsey A. , Holte Lenore , O'Hollearn Tammy , Walker Elizabeth , Clark Jacob , Oleson Jacob 
Published: May 2017

PurposeIn this study, we examined the association between risk factors for hearing loss and early childhood hearing status (normal hearing, congenital hearing loss, or delayed-onset hearing loss). Follow-up rates of audiologic care following passed or referred birth screens for children with risk factors were also examined.MethodA retrospective data review was completed on 115,039 children born from 2010 to 2012. Data analyses included prevalence rates, odds ratios, and Fisher exact tests of statistical significance.ResultsNinety percent of children were born with no risk factors for hearing loss; of those, 99.9% demonstrated normal hearing by 3 years of age. Of the 10% of children born with risk factors, 96.3% demonstrated normal hearing by age 3, 1.4% presented with congenital hearing loss, and 2.3% demonstrated permanent hearing loss by age 3. Factors that placed children at the highest risk of congenital hearing impairment were neurodegenerative disorders, syndromes, and congenital infections. Factors that placed children at the highest risk of developing permanent postnatal hearing loss were congenital cytomegalovirus, syndromes, and craniofacial anomalies.ConclusionsCertain risk factors place a child at significantly greater risk of congenital hearing impairment or developing permanent hearing loss by age 3. Follow-up diagnostic testing should remain a priority for children with certain risk factors for hearing loss.
Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science
Authors: Selvam Soundarya , James Paula 
Published: May 2017

AbstractSevere and intractable gastrointestinal bleeding caused by angiodysplasia is a debilitating problem for up to 20% of patients with von Willebrand disease (VWD). Currently, the lack of an optimal treatment for this recurrent problem presents an ongoing challenge for many physicians in their management of affected patients. Over the past few years, studies have pointed to a regulatory role for the hemostatic protein, von Willebrand factor (VWF), in angiogenesis, providing a novel target for the modulation of vessel development. This article will review the clinical implications and molecular pathology of angiodysplasia in VWD.
Drug Treatments for Core Symptoms of Autism Spectrum Disorder: Unmet Needs and Future Directions
Authors: Giovagnoli Giulia , Siracusano Martina , Postorino Valentina , Curatolo Paolo , Mazzone Luigi 
Published: May 2017

AbstractPharmacological treatments for core symptoms of Autism Spectrum Disorder (ASD) are still lacking. The clinical heterogeneity observed in this population (e.g., differences in cognitive functioning or in autism symptom severity) should be taken into account when a new drug is tested. Stratifying this population according to its neurobiological substrate could significantly improve our knowledge regarding the most appropriate pharmacological treatment for individual needs. In this review, we discuss the possible genetic and biological pathways, including the Glutamatergic, GABAergic, and mTOR systems, involved in the pathophysiology of autism, as well as the mechanisms that may be targeted by new drug interventions. Finally, we describe the current progress from the preclinical and clinical studies on some potential therapeutic options for ASD core symptoms.
Conservation Challenges and Research Needs for Pacific Lamprey in the Columbia River Basin
Authors: Clemens Benjamin J. , Beamish Richard J. , Coates Kelly C. , Docker Margaret F. , Dunham Jason B. , Gray Ann E. , Hess Jon E. , Jolley Jeffrey C. , Lampman Ralph T. , McIlraith Brian J. , Moser Mary L. , Murauskas Joshua G. , Noakes David L. G. , Schaller Howard A. , Schreck Carl B. , Starcevich Steven J. , Streif Bianca , Wetering Stan J. , Wade Joy , Weitkamp Laurie A. , Wyss Lance A. 
Published: May 2017

Abstract
The Pacific Lamprey Entosphenus tridentatus, an anadromous fish native to the northern Pacific Ocean and bordering freshwater habitats, has recently experienced steep declines in abundance and range contractions along the West Coast of North America. During the early 1990s, Native American tribes recognized the declining numbers of lamprey and championed their importance. In 2012, 26 entities signed a conservation agreement to coordinate and implement restoration and research for Pacific Lamprey. Regional plans have identified numerous threats, monitoring needs, and strategies to conserve and restore Pacific Lamprey during their freshwater life stages. Prime among these are needs to improve lamprey passage, restore freshwater habitats, educate stakeholders, and implement lamprey-specific research and management protocols. Key unknowns include range-wide trends in status, population dynamics, population delineation, limiting factors, and marine influences. We synthesize these key unknowns, with a focus on the freshwater life stages of lamprey in the Columbia River basin.
Targeted Catch-and-Release of Prohibited Sharks: Sand Tigers in Coastal Delaware Waters
Authors: Kilfoil James P. , Wetherbee Bradley M. , Carlson John K. , Fox Dewayne A. 
Published: May 2017

Abstract
The popularity of recreational shark fishing appears to be on the rise in recent years, with current policies often failing to address the direct targeting of protected species in this sector. Examination of catch trends from the past decade revealed that more than 66 million sharks were caught by recreational anglers along the U.S. eastern coast alone, including more than 1.2 million prohibited species. Using Sand Tigers Carcharias taurus captured by volunteer anglers as a case study to evaluate post-release mortality, 33 individuals were fitted with external acoustic tags and passively tracked using an array of acoustic receivers. Although rates of internal hooking and gear retention were high (57% and 60%), short-term post-release mortality was relatively low (6%) and was heavily influenced by hook location and retention. Given the dramatic increase in the range and extent of recreational fishing targeting prohibited species, even relatively low mortality rates may still pose a significant threat to recovery.
Antimicrobial constituents of peel and seeds of camu-camu (Myrciaria dubia)
Authors: Kaneshima Tai , Myoda Takao , Toeda Kazuki , Fujimori Takane , Nishizawa Makoto 
Published: May 2017

AbstractVarious antimicrobial constituents of camu-camu fruit were isolated. Acylphloroglucinol (compound 1) and rhodomyrtone (compound 2) were isolated from the peel of camu-camu (Myrciaria dubia) fruit, while two other acylphloroglucinols (compounds 3 and 4) were obtained from camu-camu seeds. The structures of the isolated compounds were characterized by spectrophotometric methods. Compounds 1 and 4 were confirmed to be new acylphloroglucinols with different substituents at the C7 or C9 position of 2, and were named myrciarone A and B, respectively. Compound 3 was determined to be isomyrtucommulone B. This is the first report of the isolation of 3 from a natural resource. The antimicrobial activities of compounds 1, 3, and 4 were similar to those of 2, and the minimum inhibitory concentrations were either similar to or lower than that of kanamycin. These results suggest that the peel and seeds of camu-camu fruit could be utilized for therapeutic applications.
McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences
Authors: Tickotsky Nili , Sagiv Tal , Prilusky Jaime , Shifrut Eric , Friedman Nir 
Published: May 2017

Abstract

Motivation
While growing numbers of T cell receptor (TCR) repertoires are being mapped by high-throughput sequencing, existing methods do not allow for computationally connecting a given TCR sequence to its target antigen, or relating it to a specific pathology. As an alternative, a manually-curated database can relate TCR sequences with their cognate antigens and associated pathologies based on published experimental data.

Results
We present McPAS-TCR, a manually curated database of TCR sequences associated with various pathologies and antigens based on published literature. Our database currently contains more than 5000 sequences of TCRs associated with various pathologic conditions (including pathogen infections, cancer and autoimmunity) and their respective antigens in humans and in mice. A web-based tool allows for searching the database based on different criteria, and for finding annotated sequences from the database in users’ data. The McPAS-TCR website assembles information from a large number of studies that is very hard to dissect otherwise. Initial analyses of the data provide interesting insights on pathology-associated TCR sequences.

Availability and implementation
Free access at http://friedmanlab.weizmann.ac.il/McPAS-TCR/.
Ridge virtual population analysis to reduce the instability of fishing mortalities in the terminal year
Authors: Okamura Hiroshi , Yamashita Yuuho , Ichinokawa Momoko 
Published: May 2017

AbstractTuned virtual population analyses are widely used for fisheries stock assessments. However, accurately estimating abundances and fishing mortality coefficients in the terminal year using tuned virtual population analyses is generally difficult, particularly when there is a limited number of available abundance indices. We propose a new method of integrating the tuned virtual population analyses with a ridge regression approach. In our method, penalization in the ridge regression is applied to the age-specific fishing mortalities in the terminal year, and the penalty parameter is automatically selected by minimizing the retrospective bias. Therefore, our method is able to simultaneously obtain a stable estimation of fishing mortality coefficients in the terminal year and reduce retrospective bias. Simulation tests based on the northern Japan Sea stock of walleye pollock (Gadus chalcogrammus) in the Sea of Japan demonstrated that this method yielded less biased estimates of abundances and avoided overestimations of fishing mortality coefficients in the terminal year. In addition, despite limited abundance indices, our method can perform reliable abundance estimations even under hyperstability and hyperdepletion conditions.
Mucocutaneous Hyperpigmentation in a Patient With a History of Both Minocycline and Silver Ingestion
Authors: Fernandez-Flores Angel , Nguyen Thao , Cassarino David S. 
Published: May 2017

Abstract:
Minocycline is a derivative of tetracycline. It has been widely used in dermatology for the treatment of acne and rosacea. One of its adverse effects is pigmentation of various body tissues. Clinically, 3 main distinct types of hyperpigmentation by minocycline have been distinguished: type I, with blue-gray to black pigment on the face in areas of scarring or inflammation; type II, with blue-gray pigment on normal skin of the legs, forearms and on the shins; and type III, with a diffuse muddy-brown discoloration in areas of sun exposure. In the current report, we present the case of a 50-year old man with a history of severe acne treated with minocycline in the past, who currently complained about discoloration of his face. He had also taken colloidal silver supplements for “good health” about 16 years ago. Physical examination revealed gray-blue discoloration on the face, sclera, hard palate and back. Histologic examination showed intracellular pigment deposits in macrophages of the superficial dermis in a perivascular and an interstitial distribution. The pigment stained with Fontana-Masson and von Kossa, whereas it was Perls' iron negative. This case does not fit well into any of the previously described patterns of minocycline-related hyperpigmentation.