bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Outcomes of Anterior Cruciate Ligament Suture Repair in Comparison with Anterior Cruciate Ligament Reconstruction in Anterior Cruciate Ligament Rupture: A systematic review and meta-analysis
Authors: Febriana Andini , Wien Aryana I Gusti Ngurah , Astawa Putu 
Published: October 2024

Background: The goal standard of the treatment is the reconstruction of ACL. However, the result is not satisfactory due to the high risk of re-rupture and early post-traumatic osteoarthritis. The emerging technique was ACL suture repair which seems to be a promising technique. However, the functional outcome of this technique compared to ACL reconstruction is still controversial. This study aimed to compare the functional outcome of ACL suture repair and ACL reconstruction to treat ACL rupture through meta-analysis and systematic review. Method: This was a systematic review and meta-analysis study. The systematic searching was performed using the keywords (anterior cruciate ligament suture repair) AND (anterior cruciate ligament reconstruction) in the MEDLINE, CENTRAL, and EMBASE databases. The outcomes of interest were the mean score of the International Knee Documentation Committee Subjective Knee Form (IKDC) and the objective IKDC score. The objective IKDC score was dichotomized into favorable and unfavorable outcomes. The mean difference and risk ratios (RR) were pooled and analyzed using software Review Manager 5.3. Result: ACL suture repair is significantly more favorable than ACL reconstruction in terms of subjective IKDC score (MD 6.43; 95%CI 2.61 – 10.26; p = 0.001). There is no significant difference in favorable outcome (objective IKDC score) between ACL suture repair and ACL reconstruction (RR 0.94; 95%CI 0.81 – 1.10; p =0.44). Conclusion: ACL suture repair is superior to ACL reconstruction in regard to subjective satisfaction based on subjective IKDC score. However, we found no significant difference in objective functional outcomes.
Remnant Preserving Posterior Transseptal Technique Provide Safe Passage for Posterior Cruciate Ligament Reconstruction
Authors: Albar Husnul Fuad , Yudha Dibrata R Permana , Widjaja Arya Cipta 
Published: October 2024

Introduction: General reconstruction procedure of the PCL usually sacrificed its remnant and footprints to allow for better tunnel placement. Better visualization, uncomplicated graft passing, dan elimination of the “killer turn” were mentioned as the possible benefits of utilizing the posterior transseptal portal, while preservation of the PCL remnant was widely encouraged for restoring knee kinematics and healing of the graft. Objectives: This study is aimed to evaluate the functional and clinical outcomes of PCL reconstruction using posterior transseptal remnant preservation technique. Materials & Methods: Five cases were included in this study. Follow-up was performed at four weeks and consisted of International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Lysholm knee scoring scale, and post-operative complications. All patients underwent similar post-operative rehabilitation program. Results: Improvement in IKDC, KOOS, and Lysholm score was recorded in all cases. There were no post-operative complications found at the time of reporting. Conclusions: Posterior transseptal portal, which was created through the posterior septum from the posteromedial to the posterolateral compartment, or conversely, is a safe arthroscopic procedure. It offers great visualization of the posterior compartment, without damaging the capsule and neurovascular bundle, while also provides satisfactory early outcomes when used in conjunction with the remnant preservation technique.
The Potency of Induced Pluripotent Stem Cell as a New Promising Treatment Regeneration: A Systematic Review
Authors: Setyawardani Astuti , Bastian Johan 
Published: October 2024

Introduction and Objective: Articular cartilage has a restricted capacity for self-regeneration when injured through trauma or disease. The inability to treat focal chondral lesions results in changes that inevitably progress to osteoarthritis. Lately, there have been many developments in the use of cell-based regenerative therapies for cartilage defects. The improvement of regenerative treatments for cartilage injury has been enormously supported by recent advances in stem cell biology. Some potential cell-based regenerative therapies include chondrocytes, multipotent stem cells (e.g. multipotent stem cells [MSCs]), and pluripotent stem cells (e.g. embryonic stem cells [ESCs]). All of these developments are mostly successful but have some limitations such as ethical issues and the potential for immunogenic or teratoma formation. Induced pluripotent stem cell (iPSC) has the potential to provide a prosperous cell source for tissue engineering, as well as produce patient-matched in vitro model study genetics and environmental factor in cartilage regeneration and prevent osteoarthritis. This systematic review aimed to investigate the potency of iPSC for cartilage regeneration through in vivo models. Material and Methods: Up until July 2023, multiple electronic databases (PubMed, Google Scholar, and Science Direct) were searched. Original research articles or research reports were included. Review, case report, case series, and conference abstract were excluded. Articles with full-text unavailability, non-English, and irrelevant topics were also excluded. The included studies were assessed for risk of bias using the systematic review center for laboratory animal experimentation (SYRCLE) Results: A total of 1072 studies were recorded from all databases. Amongst them, five studies, all original research articles, were eligible for qualitative synthesis. All of these articles show that iPSCs have the potential to produce high-quality cartilage regeneration which can successfully repair cartilage defects in vivo studies. Furthermore, no abnormal proliferation or teratoma was detected. Conclusion: The use of iPSC could be a new promising treatment in the use of cell-based regenerative therapies with unlimited pluripotent tissue regeneration with minimally ethical issues. In addition, further research related to clinical trials, dosage, method of administration, and long-term side effects are still needed further
The Influence of Anterior Translation of the Tibia with Patellar Height Measurements in Anterior Cruciate Ligament Insufficient Knee
Authors: Pontoh Ega , Zufar Muhammad , Fathurrahman Irfan , Pontoh Ludwig Andre , Tua Lubis Andri Maruli , Dilogo Ismail Hadisoebroto , Fiolin Jessica 
Published: October 2024

Introduction and Objectives: Anterior cruciate ligament (ACL) injury is one of the most common knee injuries in sport activities. Diagnosis of ACL injury relies on examining primary and secondary signs through magnetic resonance imaging (MRI) and definitively through arthroscopy. Anterior translation of the tibia (ATT) of ≧7 mm has been an established secondary sign of ACL injury visualised in MRI. Furthermore, patellar malalignment was associated with ACL injury which can be detected through several patellar height measurements. The present study aimed to examine the differences in patellar height measurements between ACL insufficient knees with ATT ≧7 mm and <7 mm, and the association between ATT and patellar height measurements. Materials and Methods: A total of 133 study participants with ACL injury were included in this study. Study participants were examined clinically and radiologically. Furthermore, all study participants underwent arthroscopic ACL reconstruction surgery. Age, gender, and BMI were recorded during admission. All study participants underwent MRI scan to assess ATT and patellar height measurements which include Insall-Salvati ratio, Modified Insall-Salvati ratio, Caton-Deschamps index, and Blackburne-Peel ratio. Independent sample T-test was carried out to compare parameters between ATT values. Linear regression was done to examine the association between ATT and patellar height measurements. Results: There were significant differences between those with ≧7 mm and <7 mm of ATT in patellar tendon length [42.14 (4.95) vs 43.98 (5.33), p=0.045] and Insall-Salvati ratio [1.04 (0.16) vs 1.11 (0.16), p=0.017]. Every increase in ATT was negatively associated with Insall-Salvati ratio (regression coefficient -5.71, 95%CI -8.67, -2.75, p<0.001) and Caton-Deschamps index (regression coefficient -2.90, 95%CI -5.75, -0.04, p=0.047) after adjusting to age, sex, and BMI. Conclusion: Greater anterior translation of the tibia was associated with a reduction in Insall-Salvati ratio and Caton-Deschamps index. Lower value of patellar tendon length and Insall-Salvati ratio was observed in subjects with ATT ≧7 mm. The findings in this study signify the role of ACL injury in demonstrating patellar malalignment secondary to increased ATT.
Characteristics of Ruptured Anterior Cruciate Ligament (ACL) Patients at Siti Fatimah Regional Hospital South Sumatera
Authors: Simanungkalit Ian Ervan , Putra Ramadhan Ananditia 
Published: October 2024

Introduction: The anterior cruciate ligament is one of the two cruciate ligaments that aids in stabilizing the knee joint. ACL injuries are injuries common in the young adult population. The incidence of ACL injuries is more than 200,000 worldwide. Many factors can cause ACL injuries. The purpose of this study was to assess the characteristics of patients with ACL injuries at Siti Fatimah Regional General Hospital South Sumatera period 2021-2023. Materials and Method: This study is a descriptive retrospective study, data taken from medical records of ACL Injuries patients treated in Siti Fatimah Regional General Hospital for the 2021-2023 period. Sampling used total sampling. Results: Patients receiving ACL treatment at Siti Fatimah Regional General Hospital for the 2021-2023 period total 8 people with ages ranging from 19-43 years and an average age of 28 years. Most patients occur in men with 62.5%, 75% occur in the right knee, 37.5% didn’t finish school and 75% unemployed. Conclusions: From the results of this study, the characteristics of patients with ACL rupture were found to be on average at the age of 28 years, male gender, most location of injuries at right knee, didn’t finish school and unemployed.
Medial Meniscus Root Reconstruction using Gracillis Tendon Autograft in Managing Medial Meniscus Posterior Root Tear: A Preliminary Case Series
Authors: Fidiasrianto Kevin , Riantho Albert , Ivander Gian , Parsaoran Butarbutar John Christian 
Published: October 2024

Introduction: Medial Meniscus Posterior root tears (MMPRT) are defined as complete radial tear within 10 mm from the meniscus attachment or bony root avulsion. Currently, repair of meniscal root injuries is the treatment of choice with the aim of restoring joint kinematics, contact pressures, and delaying the development of OA. Although encouraging results have been reported, the repair techniques do not provide any biological substance to stimulate biological healing, remembering that the attachment of medial meniscus root to the tibial plateu contain a ligament-like structures, the usage of graft may recreate that ligamentous structure. Therefore the purpose of this case series is to describe the clinical outcome of medial meniscus root reconstruction in 3 cases of degenerative MMPRT. Method: Three patients was diagnosed with MMPRT by a history taking, physical examination and the use of non-contrast knee MRI. All of the patients underwent arthroscopic surgical reconstruction with 2 tunnel transtibial pullout repair (TPR) technique and the use of gracillis tendon autograft (3 mm in diameter, 6 cm in length) that is passed through the meniscus. The surgery was performed by one orthopaedic surgeon. Follow up was done at 3 month after the surgery. KOOS and VAS are used to assess both patient subjective outcome and pain score. Result and Discussion: Patients underwent reconstruction shows an improvement in KOOS and VAS score. The average improvement in total KOOS is 43% and VAS score is 6,3 points. From the study by Wendel et al. meniscus root reconstruction can provide reattachment to the anatomic footprint and cartilaginous graft to facilitate healing. Also in agreement with the study by Li et al arthroscopically assisted meniscus root reconstruction with gracillis autograft showed superior clinical outcome and meniscus root healing rate. Conclusion: Meniscus root reconstruction showed a promising result in managing patients with MMPRT. No serious complications are reported.
Outcome of Meniscus Repair vs Meniscectomy in 40 Years and Older Patient: Systematic Review and Meta Analysis of Direct Comparative Studies
Authors: Barustan Muhammad Fakhri , Shiddieqy Pohan Muhammad Alvin 
Published: October 2024

Introduction and Objectives: An older age of the patient is a common reason for choosing meniscectomy instead of meniscus repair. Lately, there have been more meniscus repairs done for all ages. But not many studies have looked at how well meniscus repair works compare to meniscectomy in people who are 40-years-old and older. And there is not a lot of review of the studies about how well meniscus repair works. The goal of this research was to look at the results of a recent study on patients who were 40-years-old and older and had either meniscus repair or meniscectomy. The hypothesis was that repair the meniscus would give better results than meniscectomy procedure in patients who are 40-years-old and older. Materials and Methods: The study design was following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, including 5 comprehensive literature databases. Inclusion criteria: (1) Patient with meniscus tear who got arthroscopic meniscal repair or meniscectomy; (2) Studies were written in English, (3) Studies are direct outcome comparison between Meniscus repair to meniscectomy. Exclusion criteria: (1) Studies other than direct comparison of Meniscus repair to meniscectomy; (2) Expert opinions, case reports, case series, review articles, and meta-analyses were excluded.; (3) Studies did not analyzed outcomes evaluations. Search terms used are included the following: (menisci OR meniscus) AND (meniscus injuries OR menisci tear) AND (meniscectomy OR meniscus repair) AND (40 Years old or Elderly). Result: A total of 3 studies with sample of 220 knees were direct outcome comparison of meniscus repair and meniscectomy in 40 years old and older. The Lysholm score and IKDC score of Meniscus repair are superior and statistically significant compare to meniscectomy. The satisfactory score of meniscus repair is superior but not statistically significant compare to meniscectomy. Conclusion: This study found that meniscus repair in patients with meniscus tear in 40 years old and older has better clinical outcomes than meniscectomy. But, the study has a limitation because the lack of RCT studies. We need future RCT studies for a better result of the study.
Outcomes Comparison in Anterior Cruciate Ligament Reconstruction Between Hamstring Tendon and Quadriceps Tendon Autograft: A Systematic Review and Meta-Analysis
Authors: Randy  , Yosua Khandar , Guntara Aswin , Dasril Demy Faheem 
Published: October 2024

Introduction and Objectives: Anterior cruciate ligaments (ACL) accounted for the most frequent ligamentous injury. ACL reconstruction (ACLR) when indicated, has been the standard of care to treat instability and to restore functional stability.While hamstring tendon autografts (HT) are commonly used in ACLR, quadriceps tendon autografts (QT) have gained popularity in recent years Thus, this study performed a systematic review and meta-analysis comparing the outcomes of QT to HT for ACLR. Materials and Methods: Comprehensive database searches were performed in two databases, 452 studies were found and 14 studies were included in the study. This study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guideline. Included studies will be extracted for characteristics such as author, study year, design, and outcomes. Results: Fourteen studies were included in the study after a comprehensive literature search was done. 2219 patients, 847 were treated with QT and 1372 were treated with HT, functional outcomes such as International Knee Documentation Committee score (IKDC), Cincinnati score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Lysholm score, Tegner score, VAS score, active knee flexion, return to previous activity, and Patient and Observer Scar Assessment Scale(POSAS) were measured, there were differences in KOOS pain score and Symptom score with mean difference of 2.40 (95%CI 0.75 to 4.06, I2=26%, p=0.004), and 4.40 (95%CI 0.81 to 7.89, I2= 60%, p=0.02) respectively. However, there were no significant differences in other functional outcomes and secondary outcomes. Conclusion: This study demonstrates comparable results between ACLR using QT and HT. QT appeared to have better functional outcomes in KOOS pain and KOOS symptoms than in HT
The effects of the changes in the depression on suicidal ideation among older adults aged 75 and above before and after the COVID-19
Authors: Jeong Kyu-Hyoung , Cho Sunghwan , Hwang Yeon Jae , Park Dayoon , Lee Seoyoon 
Published: October 2024

Abstract
Background
The unprecedented pandemic situation of COVID-19 has had a negative impact on the mental health of many people, especially among the "old-old" older adults who are aged 75 or older. Therefore, the aim of this study is to investigate the changes in depression among "old-old" older adults before and after the onset of COVID-19, and the extent to which depression affects suicidal ideations.

Method
The 12th to 16th Korea Welfare Panel Study(KoWePS) conducted from 2017 to 2021 was used for analysis. For this study, 771 older individuals with complete data to estimate the degree of change of depression were selected as the final analysis subjects.

Result
A Growth Mixture Modeling(GMM) analysis was conducted, resulting in the classification of two groups: an increasing group and a decreasing group. The study findings showed that "old-old" older individuals with high levels of depression, specifically those in the decreasing group, may be more susceptible to suicidal ideation. Despite this steep change slope, the decreasing group still exhibited a higher level of depression in 2021 compared to the increasing group. As per characteristics, the decreasing group, which showed a higher prevalence of suicidal ideation, had a higher proportion of women and individuals with lower levels of education, those living alone, and a lower household income compared to the increasing group.

Conclusion
It is important to note that although the study emphasized the need to prioritize intervention for the decreasing group with consistently high levels of depression, the majority of individuals belong to the increasing group, which exhibited a gradual increase in depression levels over time. Therefore, intervention plans should be developed concurrently for both groups. Also, it is crucial to implement proactive efforts targeting groups with understandings of these characteristics when establishing preventative measures for depression and suicidal ideation among "old-old" older adults.
Spartalizumab in combination with platinum-doublet chemotherapy with or without canakinumab in patients with PD-L1-unselected, metastatic NSCLC
Authors: Santoro Armando , Pilar Garrido , Tan Daniel S.W. , Zugazagoitia Jon , Shepherd Frances A. , Bearz Alessandra , Barlesi Fabrice , Kim Tae Min , Overbeck Tobias R. , Felip Enriqueta , Cai Can , Eddy Simantini , McCulloch Tracey , Schaefer Eric S. 
Published: October 2024

Abstract
Background
Despite promising outcomes of treatment with anti-programmed cell death (PD)-1/PD-ligand (L)1 agents in combination with platinum-doublet chemotherapy (PDC) in the first-line setting, a significant unmet medical need remains in patients with PD-L1-unselected non-small cell lung cancer (NSCLC).

Methods
This multicenter, open-label, phase 1b study comprising dose-confirmation and dose-expansion parts investigated the combination of spartalizumab and various PDC regimens, with or without canakinumab, in treatment-naïve patients with PD-L1-unselected, metastatic NSCLC. The primary objectives were to determine maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE) of spartalizumab, with or without canakinumab, in combination with PDC in the dose-confirmation part and antitumor activity of spartalizumab in the dose-expansion part.

Results
The MTD/RDE of spartalizumab was 300 mg every 3 weeks (Q3W) when administered with either gemcitabine (1250 mg/m2)/cisplatin (75 mg/m2) (group A; no dose-limiting toxicities [DLTs]), pemetrexed (500 mg/m2)/cisplatin (group B; 2 DLTs: grade 2 posterior reversible encephalopathy syndrome and grade 4 hyponatremia), or paclitaxel (200 mg/m2)/carboplatin area under the curve 6 min*mg/mL (group C; 1 DLT: grade 4 neutropenic colitis). The RDE of canakinumab combined with spartalizumab and pemetrexed/cisplatin (group E; no DLTs) was 200 mg Q3W (no dose-expansion part was initiated). No new safety signals were identified. In groups A, B, C, and E, the overall response rates were 57.6%, 55.3%, 51.5%, and 57.1%, respectively. Group B compared with other groups had the longest median progression-free survival (10.4 months vs. 6.2–7.5 months), overall survival (29.7 months vs. 16.1–21.0 months), and duration of response (30.1 months vs. 6.0-8.2 months).

Conclusions
The combination of spartalizumab and PDC, with or without canakinumab, was well tolerated across treatment groups. The antitumor activity across treatment groups was comparable with that of pembrolizumab and pemetrexed combination. Canakinumab did not appear to improve the antitumor activity when combined with spartalizumab, pemetrexed and cisplatin.

Trial registration
The trial was registered in Clinicaltrials.gov with identifier no. NCT03064854. Date of Registration: 06 February 2017.