bluuebunny/crossref_metadata_2025_split huggingface dataset:
The demography of tree species response to climate: sapling and canopy tree survival
Authors: Canham Charles D. , Murphy Lora 
Published: February 2017

AbstractTraits affecting survival from seedling through adult stages are key elements of tree life histories, and it is widely assumed that variation in survival of adult trees plays an important role in the distribution of species along climate gradients. We use data from plots censused by the U.S. Forest Service Forest Inventory and Analysis program during the years 2000–2011 to quantify relationships between two key aspects of climate—mean annual temperature and growing season water deficit—and rates of sapling and canopy tree survival for the 50 most common tree species in the eastern United States. Our analyses include consideration of the effects of tree size, competition, and nitrogen deposition to avoid confounding effects and to provide context for the importance of variation in climate relative to other factors. Tree size and competitive effects, including the effect of tree size on sensitivity to competition, had the greatest impact on observed variation in survival for all of the species. Survival varied as a function of nitrogen deposition in 20 of the 50 species, and responses were stronger in saplings than in canopy trees. Despite clear sorting of the presence of the tree species along regional gradients of temperature and water deficit, there was only modest evidence that either sapling or canopy tree mortality varied systematically along those gradients. For 24 of the 50 species, the most parsimonious models did not include either temperature or water deficit variables. The exceptions to this were for several species of colder climates in which survival declined significantly in warmer climates. In 40 of the 50 species, there was no significant variation in survival as a function of either average growing season water deficit or the most extreme individual growing season water deficit during the 20 yr preceding the end of the census interval. The frequency of all but the most xeric of our study species declines at some point along a water deficit gradient. But it is seedling survival (reported in earlier work), rather than survival of saplings and canopy trees, that varies systematically along water deficit gradients.
A Reduced Graphene Oxide‐based Electrochemical DNA Biosensor for the Detection of Interaction between Cisplatin and DNA based on Guanine and Adenine Oxidation Signals
Authors: Yardım Yavuz , Vandeput Marie , Çelebi Metin , Şentürk Zuhre , Kauffmann Jean‐Michel 
Published: February 2017

AbstractA glassy carbon electrode (GCE) was modified by electrochemically reduced graphene oxide (ERGO) for subsequent dsDNA immobilization. The interaction of cisplatin with dsDNA was studied at this modified electrode. Quantitative investigations were performed by adsorptive transfer stripping voltammetry (AdTSV) using differential pulse voltammetry (DPV). The morphology and structure of graphene oxide (GO) and ERGO modified GCEs (GO/GCE and ERGO/GCE, respectively) were characterized by UV‐vis, FT‐IR, Raman spectroscopy and cyclic voltammetry. Compared with the bare GCE and the GO/GCE, the ERGO/GCE exhibited excellent electrocatalytic activity towards the oxidation of dsDNA due to guanine and adenine groups, testified by high oxidation peak currents and decreased oxidation potentials. The interaction of micromolar concentrations of cisplatin with surface confined dsDNA was readily detected as inferred from the decrease of the voltammetric oxidation peaks of guanine and adenine. This trend was significantly greater at the ERGO/GCE compared to the GO/GCE. The interaction of cisplatin with dsDNA was also studied in solution phase by AdTSV with detection at the ERGO/GCE.
Carbon Dioxide Electroreduction using a Silver–Zinc Alloy
Authors: Hatsukade Toru , Kuhl Kendra P. , Cave Etosha R. , Abram David N. , Feaster Jeremy T. , Jongerius Anna L. , Hahn Christopher , Jaramillo Thomas F. 
Published: February 2017

AbstractWe report on CO2 electroreduction activity and selectivity of a polycrystalline AgZn foil in aqueous bicarbonate electrolyte. X‐ray photoelectron spectroscopy (XPS) and X‐ray diffraction (XRD) measurements show that the alloy foil was slightly enriched in zinc both at the surface and in the bulk, with a surface alloy composition of 61.3±5.4 at % zinc and with Ag5Zn8 as the most prominent bulk phase. AgZn is active for CO2 reduction; CO is the main product, likely due to the weak CO binding energy of the surface, with methane and methanol emerging as minor products. Compared to pure silver and pure zinc foils, enhancements in activity and selectivity for methane and methanol are observed. A five‐fold increase is observed in the combined partial current densities for methane and methanol at −1.43 V vs. the reversible hydrogen electrode (RHE), representing a four‐ to six‐fold increase in faradaic efficiency. Such enhancements indicate the existence of a synergistic effect between silver and zinc at the surface of the alloy that contributes to the enhanced formation of further reduced products.
Optimal power allocation for relay‐based cooperative communication systems with energy harvesting
Authors: Ajirak Marzieh , Omidi Mohammad Javad , Saeedi‐Sourck Hamid , Minasian Arin 
Published: February 2017

AbstractIn this paper, the problem of throughput maximization in cooperative communication systems is considered, in which the nodes use energy harvesters instead of conventional energy sources. The 3‐node Gaussian relay channel with decode‐and‐forward relaying scheme is investigated, where the source and relay harvest energy from the environment. In this work, optimal power levels for 2 cases are obtained. First, a deterministic model is considered, where the noncausal (offline) knowledge of the harvested energy and channel states is available. The problem is shown to be a convex optimization problem, where the solutions to which are derived using convex optimization techniques. Then, the online case is investigated, in which only the casual knowledge of the harvested energy and channel states are used. In the online setting, the problem is formulated as a Markov decision process. The performance of the system in both offline and online cases, along with a few suboptimal schemes introduced in the literature, is evaluated using computer simulations.
Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma. The Hellenic experience
Authors: Angelopoulou Maria K. , Vassilakopoulos Theodoros P. , Batsis Ioannis , Sakellari Ioanna , Gkirkas Konstantinos , Pappa Vasiliki , Giannoulia Panagiota , Apostolidis Ioannis , Apostolopoulos Christos , Roussou Paraskevi , Panayiotidis Panayiotis , Dimou Maria , Kyrtsonis Marie‐Christine , Palassopoulou Maria , Vassilopoulos Georgios , Moschogiannis Maria , Kalpadakis Christina , Margaritis Dimitrios , Spyridonidis Alexander , Michalis Eurydiki , Anargyrou Konstantinos , Repousis Panagiotis , Hatzimichael Eleutheria , Bousiou Zoi , Poulakidas Elias , Grentzelias Dimitrios , Harhalakis Nikolaos , Pangalis Gerassimos A. , Anagnostopoulos Achilles , Tsirigotis Panagiotis 
Published: February 2017

AbstractThis retrospective study aimed to describe the Hellenic experience on the use of brentuximab vedotin (BV) in relapsed/refractory (R/R) Hodgkin lymphoma (HL) given within its indication. From June 2011 to April 2015, ninety‐five patients with R/R HL, who received BV in 20 centers from Greece, were analyzed. Their median age was 33 years, and 62% were males. Sixty‐seven patients received BV after autologous stem cell transplantation failure, whereas 28 patients were treated with BV without a prior autologous stem cell transplantation, due to advanced age/comorbidities or chemorefractory disease. The median number of prior treatments was 4 and 44% of the patients were refractory to their most recent therapy. The median number of BV cycles was 8 (range, 2‐16), and the median time to best response was the fourth cycle. Fifty‐seven patients achieved an objective response: twenty‐two (23%), a complete response (CR), and 35 patients (37%), a partial, for an overall response rate of 60%. Twelve patients (13%) had stable disease, and the remaining twenty‐six (27%) had progressive disease as their best response. At a median follow‐up of 11.5 months, median progression‐free survival and overall survival were 8 and 26.5 months, respectively. Multivariate analysis showed that chemosensitivity to treatment administered before BV was associated with a significantly increased probability of achieving response to BV (P = .005). Bulky disease (P = .01) and response to BV (P <.001) were significant for progression‐free survival, while refractoriness to most recent treatment (P = .04), bulky disease (P = .005), and B‐symptoms (P = .001) were unfavorable factors for overall survival. Among the 22 CRs, 5 remain in CR with no further treatment after BV at a median follow‐up of 13 months. In conclusion, our data indicate that BV is an effective treatment for R/R HL patients even outside clinical trials. Whether BV can cure a fraction of patients remains to be seen.
Temporal trends in minimally invasive myomectomy before and after the US Food and Drug Administration recommendation against electric morcellation
Authors: Pereira Nigel , Frankel William C. , Hutchinson Anne P. , Patel Hency H. , Mostisser Cheri , Elias Rony T. 
Published: February 2017

AbstractObjectiveTo investigate the temporal trends in minimally invasive myomectomy at one reproductive medicine center before and after the US Food and Drug Administration (FDA) recommendation against electric morcellation.MethodsA retrospective chart review was undertaken of patients undergoing minimally invasive myomectomy between April 1, 2012, and April 30, 2016, at a center in New York. Temporal trends in laparoscopic myomectomy (LM), robot‐assisted laparoscopic myomectomy (RAM), and laparoscopically assisted myomectomy (LAM), and intraoperative and postoperative outcomes before and after the April 2014 recommendation were compared.ResultsMinimally invasive myomectomy was performed in 73 patients. No difference was noted in the rates of minimally invasive myomectomy 2 years before (35/74 [47.3%]) and after (38/79 [48.1%]) the FDA's recommendation. The ratio of abdominal to minimally invasive myomectomy remained relatively constant before (68/59=1.15) and during the study period (80/73=1.10). There was a significant decrease in LM and RAM and a corresponding rise in LAM immediately after the recommendation (P<0.001).ConclusionThe rates of minimally invasive myomectomy before and after the FDA's recommendation did not differ, indicating that technical modifications to laparoscopic technique can allow surgeons to offer minimally invasive myomectomy to patients with symptomatic leiomyomas.
Can Trainees Effectively Deliver Dialectical Behavior Therapy for Individuals With Borderline Personality Disorder? Outcomes From a Training Clinic
Authors: Rizvi Shireen L. , Hughes Christopher D. , Hittman Alexandra D. , Vieira Oliveira Pedro 
Published: February 2017

ObjectiveThe aim of the current study was to evaluate the effectiveness of a 6‐month course of comprehensive dialectical behavior therapy (DBT) provided in a training clinic with doctoral students as therapists and assessors.MethodClinical outcomes for 50 individuals with borderline personality disorder (80% female, Mage = 29.52 [SD = 9.64]) are reported. Reliable change indices and clinical significance were calculated for measures. Finally, our results were benchmarked against a “gold standard” randomized clinical trial (RCT; McMain et al., 2009).ResultsAnalyses with both the full sample and the treatment completers indicate significant reductions in mental health symptomatology that were reliable, clinically and statistically significant, and comparable in effect size to the benchmarked RCT.ConclusionThis DBT training clinic produced good outcomes, comparable to that of a large RCT. Results have implications for who can provide DBT treatment, as well as improving access to DBT in community settings where training clinics may be located.
Heavy gas oil biodesulfurization by Rhodococcus erythropolis ATCC 4277: optimized culture medium composition and evaluation of low‐cost alternative media
Authors: Porto Bruna , Maass Danielle , Oliveira José Vladimir , de Oliveira Débora , Yamamoto Carlos Itsuo , Ulson de Souza Antônio Augusto , Ulson de Souza Selene Maria Arruda Guelli 
Published: February 2017

AbstractBACKGROUNDThe presence of sulfur in oils causes losses in the refining process and occasions the emission of toxic gases during fuel combustion. Biodesulfurization (BDS) is a bioprocess where some bacteria selectively remove sulfur from heterocyclic compounds. However, there are some limitations to BDS industrial application such as the high costs of the nutritional medium compounds. Previous studies with Rhodococcus erythropolis ATCC 4277 strain showed that the carbon and nitrogen concentration in culture medium significantly affected heavy gas oil (HGO) desulfurization. The aim of this present work was to optimize the nutritional medium in order to reduce the costs associated with medium formulation. The replacement of a synthetic medium by waste (cassava waste) and byproducts (trub) was also evaluated.RESULTSRhodococcus erythropolis ATCC 4277 desulfurization capacity was improved by diminishing carbon source concentration from the synthetic nutritional medium. Both trub and cassava waste led to a high desulfurization rate. About 70% of sulfur compounds were removed to the three media tested, achieving a maximum desulfurization rate of 5.0×103 mg sulphur kg−1 HGO h−1.CONCLUSIONThe use of an optimized nutritional medium, cassava wastewater and trub can provide an improved methodology for BDS making potential applications in industry feasible. © 2017 Society of Chemical Industry
Effect of salinity on the microbial community and performance on anaerobic digestion of marine macroalgae
Authors: Zhang Yi , Alam Md Asraful , Kong Xiaoying , Wang Zhongming , Li Lianhua , Sun Yongming , Yuan Zhenhong 
Published: February 2017

AbstractBACKGROUNDThe main obstacle associated with methane production in anaerobic digestion processes from marine macroalgae is inhibited by the sea salts. This study aims to investigate the anaerobic digestion performance of marine macroalgae by acclimating inoculum to varying salinity, and to analyze the influence of salinity on microbial community by high‐throughput gene sequencing.RESULTSThe relationship between specific methane yield and salinity followed the third‐order polynomial equation: y = 271.533 + 6.449X − 0.261X2 + 0.002X3. The acclimating inoculum produced methane efficiently at 35 g L−1 with a specific methane yield of 220.88 mL CH4 g−1 VS. Methanogenesis was considerably impeded at salinity greater than 55 g L−1. The bacterial phyla Bacteroidetes, Firmicutes, and Proteobacteria and the Methanobacterium, Methanosaeta, and Methanosarcina genera in archaea were predominant at different salinities. Hydrogenotrophic methanogens such as Methanobacterium can tolerate salinity up to 85 g L−1, whereas acetoclastic methanogens, Methanosaeta and Methanosarcina were severely inhibited at salinity greater than 65 g L−1.CONCLUSIONThe acclimating inoculum can be used as anaerobic microbial resources for efficient methane production from marine macroalgae under seawater conditions of 35 g L−1. The hydrolytic, acidogenic, acetogenic bacteria and hydrogenotrophic methanogens normally metabolized at different salinities, whereas acetoclastic methanogens were severely inhibited at high saline conditions. © 2017 Society of Chemical Industry
The use of waste mussel shells for the adsorption of dyes and heavy metals
Authors: Papadimitriou Chrysi A , Krey Grigorios , Stamatis Nikolaos , Kallianiotis Argyris 
Published: February 2017

AbstractBACKGROUNDWaste mussel shells present a significant environmental problem in the area of Northern Greece, since they are produced in vast quantities and there is no legislation for their appropriate disposal or use. In the present study the waste shells were used for the removal of dyes and heavy metals from aqueous solutions while powdered mussel shells were added into activated sludge processes for the removal of hexavalent chromium.RESULTSPowdered mussels shells were used in standard adsorption experiments for the removal of methyl blue and methyl red as well as for the removal of Cr (VI), Cd and Cu. Also they were added into laboratory scale activated sludge reactors treating synthetic wastewater with hexavalent chromium, in order to investigate the potential attribution to the treatment efficiency.CONCLUSIONAdsorption experiments indicated almost 100% color removal. High removal efficiencies were observed for the metals, especially in the case of chromium and cadmium reached concentrations even below 1 mg L−1. The addition of powdered mussel shells in the activated sludge processes enhanced the removal of chromium and phosphorus, while enabled the formation of heavier activated sludge flocs and thus enhanced the settling properties of the activated sludge. © 2017 Society of Chemical Industry
Clinical and molecular cytogenetic analyses of four families with 1q21.1 microdeletion or microduplication
Authors: Wang Hong‐Dan , Liu Lin , Wu Dong , Li Tao , Cui Cun‐Ying , Zhang Lian‐Zhong , Wang Cheng‐Zeng 
Published: February 2017

AbstractBackgroundLittle information is available regarding the penetrance of 1q21.1 copy number variants (CNVs). In the present study, we explored the clinical significance of 1q21.1 microdeletion or microduplication.MethodsIn four families, chromosome karyotype was analyzed using G‐banding karyotype analysis technology. CNVs were detected using array‐comparative genomic hybridization (aCGH) and then a quantitative polymerase chain reaction (qPCR) was used to validate candidate CNVs. Sequence signature in the breakpoint region was analyzed using University of California Santa Cruz (UCSC) databases.ResultsExcept for karyotype 45, XX, der (13, 14) (q10, q10) in the mother (I2) of family 2, the karyotype was normal in all other members of the four families. In the mother (I2) and fetus (II2) of family 1, in newborn (II1) of family 2 and in fetus (II1) of family 3, there was 1.22‐Mb heterozygous microdeletion in the chromosome 1q21.1q21.2 region. The child (II1) of family 4 had a 1.46‐Mb heterozygous microduplication in the chromosome 1q21.1q21.2 region. The results of the qPCR were consistent with that of aCGH. There was large number of low copy repeats (LCRs) in the breakpoint region found by analysis of the UCSC database, and multiple LCRs were matched with sequences in the chromosome 1 short‐arm region.Conclusions1q21.1 microdeletion and microduplication exhibit a variety of clinical manifestations and the specificity of their clinical features is not high. The penetrance of the distal 1q21.1 microdeletion may be affected by other factors in the present study. In summary, we report the discovery of a new distal 1q21.1 microduplication, which enriches the CNV spectrum in the 1q21.1 region and is conducive to prenatal genetic counseling.
The Lived Experience of the Hospital Discharge “Plan”: A Longitudinal Qualitative Study of Complex Patients
Authors: Carusone Soo Chan , O'Leary Bill , McWatt Simone , Stewart Ann , Craig Shelley , Brennan David J. 
Published: February 2017

BACKGROUNDTransitions in care are a high‐risk time for patients. Complex patients account for the largest proportion of healthcare costs but experience lower quality and discontinuity of care. The experiences of complex patients can be used to identify gaps in hospital discharge practices and design interventions to improve outcomes.METHODSWe used a case study approach with serial interviews and chart abstraction to explore the hospital discharge and transition experience over 6 weeks. Participants were recruited from a small hospital in Toronto that provides care to complex patients living with human immunodeficiency virus (HIV). Framework analysis was used to compare data across time‐points and sources.RESULTSData were collected from 9 cases. Participants presented with complex medical and psychosocial challenges, including substance use (n = 9), mental health diagnoses (n = 8) and a mean of 5 medical comorbidities in addition to HIV. Data were analyzed and reported in 4 key themes: 1) social support; 2) discharge process and transition experience; 3) post‐discharge follow‐up; and 4) patient priorities. After hospital discharge, the complexity of participants' lives resulted in a change in priorities and subsequent divergence from the discharge plan. Despite the comprehensive discharge plans, with referrals designed to support their health and activities of daily living, participants experienced challenges with social support and referral uptake, resulting in a loss of stability achieved while in hospital.CONCLUSIONFurther investigation and changes in practice are necessary to ensure that discharge plans for complex patients are realistic within the context of their lives outside of the hospital.
MR elastography measurement of the effect of passive warmup prior to eccentric exercise on thigh muscle mechanical properties
Authors: Kennedy Paul , Macgregor Lewis J. , Barnhill Eric , Johnson Curtis L. , Perrins Michael , Hunter Angus , Brown Colin , van Beek Edwin J.R. , Roberts Neil 
Published: February 2017

PurposeTo investigate the effect of warmup by application of the thermal agent Deep Heat (DH) on muscle mechanical properties using magnetic resonance elastography (MRE) at 3T before and after exercise‐induced muscle damage (EIMD).Materials and MethodsTwenty male participants performed an individualized protocol designed to induce EIMD in the quadriceps. DH was applied to the thigh in 50% of the participants before exercise. MRE, T2‐weighted MRI, maximal voluntary contraction (MVC), creatine kinase (CK) concentration, and muscle soreness were measured before and after the protocol to assess EIMD effects. Five participants were excluded: four having not experienced EIMD and one due to incidental findings.ResultsTotal workload performed during the EIMD protocol was greater in the DH group than the control group (P < 0.03), despite no significant differences in baseline MVC (P = 0.23). Shear stiffness |G*| increased in the rectus femoris (RF) muscle in both groups (P < 0.03); however, DH was not a significant between‐group factor (P =  0.15). MVC values returned to baseline faster in the DH group (5 days) than the control group (7 days). Participants who displayed hyperintensity on T2‐weighted images had a greater stiffness increase following damage than those without: RF; 0.61 kPa vs. 0.15 kPa, P < 0.006, vastus intermedius; 0.34 kPa vs. 0.03 kPa, P = 0.06.ConclusionEIMD produces increased muscle stiffness as measured by MRE, with the change in |G*| significantly increased when T2 hyperintensity was present. DH did not affect CK concentration or soreness; however, DH participants produced greater workload during the EIMD protocol and exhibited accelerated MVC recovery.Level of Evidence: 1Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2017;46:1115–1127.