bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical study of the stability and properties of magic numbers (m = 5, n = 2) and (m = 6, n = 3) of bimetallic bismuth‐copper nanoclusters; Bim Cun
Authors: Miralrio Alan , Hernández‐Hernández Arturo , Pescador‐Rojas Jose A. , Sansores Enrique , López‐Pérez Pablo A. , Martínez‐Farías Francisco , Rangel Cortes Eduardo 
Published: August 2017

AbstractInspired by the experimental discovery of magic numbers we present a first study using density functional theory for the structure and properties of neutral and cationic Bi6Cu3 and Bi5Cu2 clusters. Our results confirm predictions based on Wade's rules. The closed electron shells, characteristic of cationic clusters help impose enhanced stability, while also complying with Wade's rules. Charge distribution analysis, as well as electrostatic potential maps show that in almost all cases, Bi atoms donate charges to Cu atoms. According to the analysis of condensed Fukui indices, Cu atoms inside both clusters are not reactive. Contrastingly, Bi atoms are reactive and may be targeted by different types of attack. This study of the electronic properties may thus help to determine experimental strategies with the capacity to enhance the synthesis of catalysts.
Attitudes of Individuals with Gaucher Disease toward Substrate Reduction Therapies
Authors: Wagner Victoria F. , Northrup Hope , Hashmi S. Shahrukh , Nguyen Joanne M. , Koenig Mary Kay , Davis Jessica M. 
Published: August 2017

AbstractType 1 Gaucher disease (GD) is the most common lysosomal storage disorder. Previously, treatment for GD was limited to intravenous enzyme replacement therapies (ERTs). More recently, oral substrate reduction therapies (SRTs) were approved for treatment of GD. Although both therapies alleviate disease symptoms, attitudes toward SRTs and patient perceptions of health while using SRT have not been well established. Electronic surveys were administered to adults with GD and asked about treatment history, attitudes toward SRTs, and perception of health while using SRTs as compared to ERTs, if applicable to the participant. ERT users that were offered treatment with SRTs cited potential side effects, wanting more research on SRTs, and satisfaction with their current treatment regimen as reasons for declining SRTs. SRT users expressed convenience and less invasiveness as reasons for choosing SRTs. Additionally, those using SRTs most often perceived their health to be similar to when they previously used ERT. Participant responses illustrate that attitudes toward SRTs can be variable and that one particular treatment may not be ideal for all patients with GD depending on individual perceptions of factors such as convenience, invasiveness, or side effects. Thus, individuals with GD should be counseled adequately by healthcare providers about both ERTs and SRTs for treatment of GD now that SRTs are clinically available.
Decoding nervous system by single‐cell RNA sequencing
Authors: Hu Ganlu , Wang Guang‐Zhong 
Published: August 2017

BackgroundMammalian brain are composed of a large number of specialized cell types with diverse molecular composition, functions and differentiation potentials. The application of recently developed single‐cell RNA sequencing (scRNA‐seq) technology in this filed has provided us new insights about this sophisticated system, deepened our understanding of the cell type diversity and led to the discovery of novel cell types.ResultsHere we review recent progresses of applying this technology on studying brain cell heterogeneity, adult neurogenesis as well as brain tumors, then we discuss some current limitations and future directions of using scRNA‐seq on the investagation of nervous system.ConclusionsWe believe the application of single‐cell RNA sequencing in neuroscience will accelerate the progress of big brain projects.
A multi-objective optimization for brush monofilament tufting process design
Authors: Salmasnia Ali , Hasannejad Saeed , Mokhtari Hadi 
Published: August 2017

Abstract
This paper addresses the optimization of monofilament tufting process as the most important and the main stage of toothbrush production in sanitary industries. In order to minimize both process time and depreciation costs, and ultimately increase the production efficiency in such an industrial unit, we propose a metaheuristic based optimization approach to solve it. The Traveling Salesman Problem (TSP) is used to formulate the proposed problem. Then by using multi-objective evolutionary algorithms, NSGA-II and MOPSO, we seek to obtain the best solution and objective functions described above. Extensive computational experiments on three different kinds of toothbrush handles are performed and the results demonstrate the applicability and appropriate performance of algorithms. The comparison metrics like spacing, number of Pareto solutions, time, mean distance from the ideal solution and diversity are used to evaluate the quality of solutions. Moreover a sensitivity analysis is done for investigation of the performance in various setting of parameters.
Key points Brush monofilament tufting process design. NSGA-II and MOPSO as multi-objective approaches. Extensive computational experiments. Comparison metrics like spacing, number of Pareto solutions, time, mean distance from ideal solution and diversity.
Operating a Motor Vehicle after Marijuana Use: Perspectives from People who use High-Potency Marijuana
Authors: Cavazos-Rehg Patricia A. , Krauss Melissa J. , Sowles Shaina J. , Zewdie Kidist , Bierut Laura 
Published: August 2017

Background With advancing marijuana legalization in the United States, a primary concern is the possible increase in consequences relating to marijuana driving impairment, especially among people who use high-potency marijuana (i.e., extracts). In this study, the research team assessed the risk perception and experiences of driving under the influence of marijuana by investigating people who use extracts. Methods Participants from 2 studies were queried about driving after using marijuana. In Study 1, phone interviews ( n = 19) were conducted with people who use extracts. In Study 2, people who use extracts ( n = 174) were recruited to participate in a nationwide survey via an online existing panel. Responses to marijuana and driving–related questions were qualitatively coded for themes (e.g., riskiness, engagement in behavior) developed by the research team. Results Prominent themes identified in Study 1 suggested a belief that driving risk following marijuana use is dependent on the individual (i.e., response/tolerance) or the amount/type of marijuana consumed. This theme was corroborated by Study 2 participants. Those who perceived no or minimal risk from driving following marijuana use were more likely to report engagement in driving following extracts use. Conclusions More research is needed to understand how marijuana, especially in its concentrated form, impacts driving ability in order to develop appropriate and scientifically sound regulations. Such research could subsequently fill the need to improve and more widely disseminate prevention messages on marijuana use and driving risks.
Interprofessional Prescription Opioid Abuse Communication among Prescribers and Pharmacists: A Qualitative Analysis
Authors: Hagemeier Nicholas E. , Tudiver Fred , Brewster Scott , Hagy Elizabeth J. , Ratliff Brittany , Hagaman Angela , Pack Robert P. 
Published: August 2017

Background Prescribers and community pharmacists commonly perceive prescription opioid abuse to be a problem in their practice settings and communities. Both cohorts have expressed support for interventions that improve interprofessional communication and reduce prescription opioid abuse. The objective of this study was to describe prescription opioid abuse-related communication among and between prescribers and community pharmacists in South Central Appalachia. Methods The investigators conducted five focus groups with 35 Appalachian Research Network practice-based research network providers between February and October, 2014. Two prescriber-specific, two pharmacist-specific, and one interprofessional (prescribers and pharmacists) focus groups were conducted, recorded, and transcribed. Data collection and analysis occurred iteratively. Emerging themes were inductively derived and refined. Five member-checking interviews were conducted to validate themes. Results Providers noted several factors that influence intraprofessional and interprofessional communication, including level of trust, role perceptions, conflict history and avoidance, personal relationships, and prescription monitoring program use. Indirect communication approaches via patients, office staff, and voicemail systems were common. Direct pharmacist to prescriber and prescriber to pharmacist communication was described as rare and often perceived to be ineffective. Prescriber to pharmacist communication was reported by prescribers to have decreased after implementation of state prescription monitoring programs. Difficult or uncomfortable conversations were often avoided by providers. Conclusions Interprofessional and intraprofessional prescription opioid abuse communication is situational and influenced by multiple factors. Indirect communication and communication avoidance are common. Themes identified in this study can inform development of interventions that improve providers’ intra- and interprofessional communication skills.
Tailoring Ecological Monitoring to Individual Marine Reserves: Comparing Longline to Hook-and-Line Gear to Monitor Fish Species
Authors: Huntington Brittany E. , Watson Jessica L. 
Published: August 2017

Abstract
Fishery-independent hook-and-line surveys are currently being used to assess marine reserve performance in California and Oregon using a regionally standardized approach. Catch compositions generated from these hook-and-line surveys (pole-and-line gear) at Oregon's southernmost marine reserve were compared with local commercial landing data. Several species present in the commercial catch were undersampled in the marine reserve hook-and-line dataset, including China Rockfish Sebastes nebulosus, Vermilion Rockfish S. miniatus, Quillback Rockfish S. maliger, Copper Rockfish S. caurinus, and Cabezon Scorpaenichthys marmoratus. We conducted a gear selectivity study to explore whether modified commercial long-lining gear could supplement current hook-and-line efforts. Both gear types were fished simultaneously from a single vessel inside and outside of the reserve. Species composition, catch rate, size distribution, and fish condition between the two gear types were compared. Catch composition differed significantly between longline and hook-and-line gear. Catch rates of nearshore rocky reef fish species were higher for longline than hook-and-line gear for all but two species. Importantly, higher catch rates were significant for three of the species of interest (Cabezon, Vermilion Rockfish, and Copper Rockfish). For four different species, larger individuals were caught on the longline compared with the hook-and-line gear. Incidence of predation and mortality were higher with long-lining but limited to three species groups: Black Rockfish S. melanops, Blue Rockfish S. mystinus and Deacon Rockfish S. diaconus complex, and Canary Rockfish S. pinniger. Symptoms of barotrauma were higher with hook-and-line gear. We demonstrated that longline gear can be used to catch and release species targeted by the local fishery and used simultaneously with hook-and-line gear from a single vessel to broaden both the species and the size ranges sampled. These results underscore the need to consider regionally standardized long-term monitoring approaches in conjunction with locally tailored efforts to generate data for detecting marine reserve effects at both local and regional scales.
Handling and Tagging Effects, In-River Residence Time, and Postspawn Migration of Anadromous River Herring in the Hudson River, New York
Authors: Eakin William W. 
Published: August 2017

Abstract
In a 2013 pilot study, acoustic tags were inserted into two species of river herring, Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis. The primary objectives were to identify handling and tagging effects and assess in-river residence time. The secondary objective was to identify postspawn coastal migration patterns. Fish were collected on spawning grounds in the upper portion of the Hudson River, New York. Vemco V7 acoustic transmitters were gastrically inserted into 25 river herring (13 Alewives and 12 Blueback Herring) that were in pre, active, or post spawning conditions. In-river acoustic data were collected from 23 of the 25 river herring. The majority of tagged fish exhibited some level of fallback (downstream migration) after the tagging event, all Blueback Herring and all male Alewives returning to spawning areas. The majority of female Alewives did not return to the spawning area after tagging, and this may be a result of when and where tagging events occurred. Both species of river herring exhibited similar in-river residence times of approximately 2–3 weeks and exited the system 3–6 d after spawning. Information on coastal movements of four Blueback Herring (two females and two males) was also obtained, spanning the south shore of Long Island, New York, to the mouth of Penobscot Bay, Maine. Coastal and in-river tag detections were reported by members of the Atlantic Cooperative Telemetry Network. In conclusion, this experiment can now be repeated with confidence on a larger scale with multiyear tags in order to identify unknown in-river spawning areas, provide information regarding spawning site fidelity, and bolster current knowledge of coastal migration patterns for both species.
Indications of Offshore Spawning by Southern Gulf of Maine Winter Flounder
Authors: Fairchild Elizabeth A. 
Published: August 2017

Abstract
This is the first study to document quantitatively that Gulf of Maine (GOM) Winter Flounder Pseudopleuronectes americanus spawn offshore. Three sites (southern Jeffreys Ledge, Bigear [an area southwest of Tillies Bank], and a portion of Stellwagen Bank National Marine Sanctuary) were sampled during spring 2016 to determine whether Winter Flounder are spawning in non-coastal, deep waters in the southern GOM. In total, 1,384 Winter Flounder were caught by trawl, measured, sexed, and assessed for reproductive stage during the peak spawning season (March–May). These fish showed clear signs that spawning was occurring either at or very near to all three sites surveyed. In all sites, a shift from prespawn to postspawn females occurred. Running ripe females were caught at both Jeffreys Ledge and Stellwagen Bank on multiple occasions, and ripe and recently spawned females were caught at Bigear. Given that these sites are over 15 km from the coast, it is not energetically likely that fish in such advanced reproductive condition are migrating to shore to spawn. Essential fish habitat (EFH) for GOM Winter Flounder is categorized as waters with depths of 5 m or less. The present study clearly shows that this depth range is incomplete and thus inaccurate for southern GOM Winter Flounder. Although it is irrefutable that GOM estuaries and shallow bays are important as nursery grounds for juvenile Winter Flounder and as postspawn feeding grounds for adults, the current GOM EFH designation warrants reclassification.
Integrating data from multiple surveys and accounting for spatio-temporal correlation to index the abundance of juvenile Pacific halibut in Alaska
Authors: Ono Kotaro , Ianelli James N , McGilliard Carey R , Punt André E 
Published: August 2017

Abstract
Survey indices of abundance are one of the main sources of information used in fish stock assessment. Many regions around the world, including the United States and Europe, develop survey protocols to aid in creating these indices. As ecosystems function as a continuum across borders, there is a need to develop a standardized framework for combining information across surveys. Such methods could help resolve differences in timing, spatial coverage, catchability, and selectivity among surveys. We present a method that uses survey data by length class. These data come from several regional surveys each with differing sampling designs, spatial and temporal coverage, and sampling gear. The method accounts for the spatio-temporal correlation structure in length-specific catch rates and occurrence, and allows for differences in catchability and selectivity among regions. The approach was applied to Pacific halibut (Hippoglossus stenolepis) in Alaska, a broadly distributed species for which there is considerable uncertainty in recent recruitment estimates. Results confirm the major recruitment event of 1987 recorded in the most recent stock assessment and also detected recruitment peaks in more recent years (1998 and 2004–2005). The signal seems to be mostly related to the Eastern Bering Sea shelf survey data. The approach introduced in this study is general and could be expanded to other regions and species where standardized survey data are collected that include extensive length and/or age measurements.
Made by Mistake: When Mistakes Increase Product Preference
Authors: Reich Taly , Kupor Daniella M , Smith Rosanna K 
Published: August 2017

Abstract
Mistakes are often undesirable and frequently result in negative inferences about the person or company that made the mistake. Consequently, research suggests that information about mistakes is rarely shared with consumers. However, we find that consumers actually prefer products that were made by mistake to otherwise identical products that were made intentionally. This preference arises because consumers perceive that a product made by mistake is more improbable relative to a product made intentionally, and thus, view the product as more unique. We find converging evidence for this preference in a field study, six experiments, and eBay auction sales. Importantly, this preference holds regardless of whether the mistake enhances or detracts from the product. However, in domains where consumers do not value uniqueness (e.g., utilitarian goods), the preference is eliminated.
Natural and Artificial Intelligence in Neurosurgery: A Systematic Review
Authors: Senders Joeky T , Arnaout Omar , Karhade Aditya V , Dasenbrock Hormuzdiyar H , Gormley William B , Broekman Marike L , Smith Timothy R 
Published: August 2017

Abstract

BACKGROUND
Machine learning (ML) is a domain of artificial intelligence that allows computer algorithms to learn from experience without being explicitly programmed.

OBJECTIVE
To summarize neurosurgical applications of ML where it has been compared to clinical expertise, here referred to as “natural intelligence.”

METHODS
A systematic search was performed in the PubMed and Embase databases as of August 2016 to review all studies comparing the performance of various ML approaches with that of clinical experts in neurosurgical literature.

RESULTS
Twenty-three studies were identified that used ML algorithms for diagnosis, presurgical planning, or outcome prediction in neurosurgical patients. Compared to clinical experts, ML models demonstrated a median absolute improvement in accuracy and area under the receiver operating curve of 13% (interquartile range 4-21%) and 0.14 (interquartile range 0.07-0.21), respectively. In 29 (58%) of the 50 outcome measures for which a P-value was provided or calculated, ML models outperformed clinical experts (P < .05). In 18 of 50 (36%), no difference was seen between ML and expert performance (P > .05), while in 3 of 50 (6%) clinical experts outperformed ML models (P < .05). All 4 studies that compared clinicians assisted by ML models vs clinicians alone demonstrated a better performance in the first group.

CONCLUSION
We conclude that ML models have the potential to augment the decision-making capacity of clinicians in neurosurgical applications; however, significant hurdles remain associated with creating, validating, and deploying ML models in the clinical setting. Shifting from the preconceptions of a human-vs-machine to a human-and-machine paradigm could be essential to overcome these hurdles.
Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents
Authors: Garami Andras , Ibrahim Mohab , Gilbraith Kerry , Khanna Rajesh , Pakai Eszter , Miko Alexandra , Pinter Erika , Romanovsky Andrej A. , Porreca Frank , Patwardhan Amol M. 
Published: August 2017

Abstract

Background
Intraoperative hypothermia and postoperative pain control are two important clinical challenges in anesthesiology. Transient receptor potential vanilloid 1 has been implicated both in thermoregulation and pain. Transient receptor potential vanilloid 1 antagonists were not advanced as analgesics in humans in part due to a side effect of hyperthermia. This study tested the hypothesis that a single, preincision injection of a transient receptor potential vanilloid 1 antagonist could prevent anesthesia-induced hypothermia and decrease the opioid requirement for postsurgical hypersensitivity.

Methods
General anesthesia was induced in rats and mice with either isoflurane or ketamine, and animals were treated with transient receptor potential vanilloid 1 antagonists (AMG 517 or ABT-102). The core body temperature and oxygen consumption were monitored during anesthesia and the postanesthesia period. The effect of preincision AMG 517 on morphine-induced reversal of postincision hyperalgesia was evaluated in rats.

Results
AMG 517 and ABT-102 dose-dependently prevented general anesthesia-induced hypothermia (mean ± SD; from 1.5° ± 0.1°C to 0.1° ± 0.1°C decrease; P < 0.001) without causing hyperthermia in the postanesthesia phase. Isoflurane-induced hypothermia was prevented by AMG 517 in wild-type but not in transient receptor potential vanilloid 1 knockout mice (n = 7 to 11 per group). The prevention of anesthesia-induced hypothermia by AMG 517 involved activation of brown fat thermogenesis with a possible contribution from changes in vasomotor tone. A single preincision dose of AMG 517 decreased the morphine dose requirement for the reduction of postincision thermal (12.6 ± 3.0 vs. 15.6 ± 1.0 s) and mechanical (6.8 ± 3.0 vs. 9.5 ± 3.0 g) withdrawal latencies.

Conclusions
These studies demonstrate that transient receptor potential vanilloid 1 antagonists prevent anesthesia-induced hypothermia and decrease opioid dose requirements for the reduction of postincisional hypersensitivity in rodents.