bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pattern of spatial flood disaster region in DKI Jakarta
Authors: Tambunan M P 
Published: March 2017

Abstract
The study of disaster flood area was conducted in DKI Jakarta Province, Indonesia. The aim of this research is: to study the spatial distribution of potential and actual of flood area The flood was studied from the geographic point of view using spatial approach, while the study of the location, the distribution, the depth and the duration of flooding was conducted using geomorphologic approach and emphasize on the detailed landform unit as analysis unit. In this study the landforms in DKI Jakarta have been a diversity, as well as spatial and temporal pattern of the actual and potential flood area. Landform at DKI Jakarta has been largely used as built up area for settlement and it facilities, thus affecting the distribution pattern of flooding area. The collection of the physical condition of landform in DKI Jakarta data prone were conducted through interpretation of the topographic map / RBI map and geological map. The flood data were obtained by survey and secondary data from Kimpraswil (Public Work) of DKI Jakarta Province for 3 years (1996, 2002, and 2007). Data of rainfall were obtained from BMKG and land use data were obtained from BPN DKI Jakarta. The analysis of the causal factors and distribution of flooding was made spatially and temporally using geographic information system. This study used survey method with a pragmatic approach. In this study landform as result from the analytical survey was settlement land use as result the synthetic survey. The primary data consist of landform, and the flood characteristic obtained by survey. The samples were using purposive sampling. Landform map was composed by relief, structure and material stone, and process data Landform map was overlay with flood map the flood prone area in DKI Jakarta Province in scale 1:50,000 to show. Descriptive analysis was used the spatial distribute of the flood prone area. The result of the study show that actual of flood prone area in the north, west and east of Jakarta lowland both in beach ridge, coastal alluvial plain, and alluvial plain; while the flood potential area on the slope is found flat and steep at alluvial fan, alluvial plain, beach ridge, and coastal alluvial plain in DKI Jakarta. Based on the result can be concluded that actual flood prone is not distributed on potential flood prone
Conformity assessment of the measurement accuracy in testing laboratories using a software application*
Authors: Diniţă A 
Published: March 2017

Abstract
This article presents a method for assessing the accuracy of the measurements obtained at different tests conducted in laboratories by implementing the interlaboratory comparison method (organization, performance and evaluation of measurements of tests on the same or similar items by two or more laboratories under predetermined conditions). The program (independent software application), realised by the author and described in this paper, analyses the measurement accuracy and performance of testing laboratory by comparing the results obtained from different tests, using the modify Youden diagram, helping identify different types of errors that can occur in measurement, according to ISO 13528:2015, Statistical methods for use in proficiency testing by interlaboratory comparison. A case study is presented in the article by determining the chemical composition of identical samples from five different laboratories. The Youden diagram obtained from this study case was used to identify errors in the laboratory testing equipment.
An Assessment of the Accuracy of Home Blood Pressure Monitors When Used in Device Owners
Authors: Ringrose Jennifer S. , Polley Gina , McLean Donna , Thompson Ann , Morales Fraulein , Padwal Raj 
Published: March 2017

Abstract

OBJECTIVE
To examine the accuracy of home blood pressure (BP) devices, on their owners, compared to auscultatory reference standard BP measurements.

METHODS
Eighty-five consecutive consenting subjects ≥18 years of age, who owned an oscillometric home BP device (wrist or upper-arm device), with BP levels between 80–220/50–120 mm Hg, and with arm circumferences between 25–43 cm were studied. Pregnancy and atrial fibrillation were exclusion criteria. Device measurements from each subject’s home BP device were compared to simultaneous 2-observer auscultation using a mercury sphygmomanometer. Between-group mean comparisons were conducted using paired t-tests. The proportion of patients with device-to-auscultatory differences of ≥5, 10, and 15 mm Hg were tabulated and predictors of systolic and diastolic BP differences were identified using linear regression.

RESULTS
Mean age was 66.4 ± 11.0 years, mean arm circumference was 32.7 ± 3.7 cm, 54% were female and 78% had hypertension. Mean BPs were 125.7 ± 14.0/73.9 ± 10.4 mm Hg for home BP devices vs. 129.0 ± 14.7/72.9 ± 9.3 for auscultation (difference of −3.3 ± 7.3/0.9 ± 6.1; P values &lt;0.0001 for systolic and 0.17 for diastolic). The proportion of devices with systolic or diastolic BP differences from auscultation of ≥5, 10, and 15 mm Hg was 69%, 29%, and 7%, respectively. Increasing arm circumference was a statistically significant predictor of higher systolic (parameter estimate 0.61 per cm increase; P value 0.004) and diastolic (0.38; 0.03) BP.

CONCLUSIONS
Although mean differences from 2-observer auscultation were acceptable, when tested on their owners, most home BP devices were not accurate to within 5 mm Hg. Ensuring acceptable accuracy of the device-owner pairing should be prioritized.
MaBoSS 2.0: an environment for stochastic Boolean modeling
Authors: Stoll Gautier , Caron Barthélémy , Viara Eric , Dugourd Aurélien , Zinovyev Andrei , Naldi Aurélien , Kroemer Guido , Barillot Emmanuel , Calzone Laurence 
Published: March 2017

Abstract

Motivation
Modeling of signaling pathways is an important step towards the understanding and the treatment of diseases such as cancers, HIV or auto-immune diseases. MaBoSS is a software that allows to simulate populations of cells and to model stochastically the intracellular mechanisms that are deregulated in diseases. MaBoSS provides an output of a Boolean model in the form of time-dependent probabilities, for all biological entities (genes, proteins, phenotypes, etc.) of the model.

Results
We present a new version of MaBoSS (2.0), including an updated version of the core software and an environment. With this environment, the needs for modeling signaling pathways are facilitated, including model construction, visualization, simulations of mutations, drug treatments and sensitivity analyses. It offers a framework for automated production of theoretical predictions.

Availability and Implementation
MaBoSS software can be found at https://maboss.curie.fr, including tutorials on existing models and examples of models.

Supplementary information
Supplementary data are available at Bioinformatics online.
Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial
Authors: Ulrich Silvia , Hasler Elisabeth D. , Saxer Stéphanie , Furian Michael , Müller-Mottet Séverine , Keusch Stephan , Bloch Konrad E. 
Published: March 2017

Aims
The purpose of the current trial was to test the hypothesis that breathing oxygen-enriched air increases exercise performance of patients with pulmonary arterial or chronic thrombo-embolic pulmonary hypertension (PAH/CTEPH) and to investigate involved mechanisms.

Methods and results
Twenty-two patients with PAH/CTEPH, eight women, means ± SD 61 ± 14 years, resting mPAP 35 ± 9mmHg, PaO2 ambient air &gt;7.3 kPa, underwent four bicycle ergospirometries to exhaustion on different days, while breathing oxygen-enriched (FiO2 0.50, hyperoxia) or ambient air (FiO2 0.21, normoxia) using progressively increased or constant load protocols (with 75% maximal work rate under FiO2 0.21), according to a randomized, sham-controlled, single-blind, cross-over design. ECG, pulmonary gas-exchange, arterial blood gases, cerebral and quadriceps muscle tissue oxygenation (CTO and QMTO) by near-infrared spectroscopy were measured. In ramp exercise, maximal work rate increased from 113 ± 38 W with normoxia to 132 ± 48 W with hyperoxia, mean difference 19.7 (95% CI 10.5–28.9) W, P &lt; 0.001. Constant load exercise endurance increased from 571 ± 443 to 1242 ± 514 s, mean difference 671 (95% CI 392–951) s, P &lt; 0.001. At end-exercise with hyperoxia PaO2, CTO, QMTO, and PaCO2 were increased, and ventilatory equivalents for CO2 were reduced while the physiological dead space/tidal volume ratio remained unchanged.

Conclusion
In patients with PAH/CTEPH, breathing oxygen-enriched air provides major increases in exercise performance. This is related to an improved arterial oxygenation that promotes oxygen availability in muscles and brain and to a reduction of the excessive ventilatory response to exercise thereby enhancing ventilatory efficiency. Patients with PAH/CTEPH may therefore benefit from oxygen therapy during daily physical activities and training.

Trial registration
clinicaltrials.gov Identifier: NCT01748474.
Humerus Lengthening With the PRECICE Internal Lengthening Nail
Authors: Kurtz Anton M. , Rozbruch S. Robert 
Published: March 2017

Background:
Deformity and growth arrest of the humerus in children may result as sequelae of proximal humerus fractures and unicameral bone cysts, or as complications of their treatment. As approximately 80% of the growth of the humerus arises from the proximal physis, the resultant upper limb-length discrepancy can be substantial. Benefits to lengthening the shortened arm have been previously demonstrated with the use of external fixation devices. To our knowledge, no reports have been published on the use of intramedullary implants for this purpose.

Methods:
A 15-year-old girl with humeral shortening secondary to proximal humeral growth disturbance following treatment for a unicameral bone cyst was treated with humeral osteoplasty and gradual lengthening with an off-label use of a fully implantable motorized intramedullary lengthening nail. A varus proximal humeral deformity and lateral starting point allowed for avoidance of the rotator cuff insertion.

Results:
Humeral lengthening (5 cm) was achieved at 9 weeks, with bony union at 7 months, and hardware removal at 9½ months. Shoulder and elbow motion was maintained during and after treatment.

Conclusions:
This is the first case report of humeral lengthening using a fully implantable motorized intramedullary lengthening nail. Although some technical limitations remain when compared with other methods, the procedure was well tolerated throughout the course of treatment.

Level of Evidence:
Level IV—case report.
Can a Novel, Low-Cost Simulation Model be Used to Teach Anterior Cruciate Ligament Graft Preparation?
Authors: Brusalis Christopher M. , Lawrence John Todd R. , Ranade Sheena C. , Kerr Joy C. , Pulos Nicholas , Wells Lawrence , Ganley Theodore J. 
Published: March 2017

Background:
This study evaluated an anterior cruciate ligament (ACL) graft preparation simulation learning model for use by orthopaedic surgery trainees.

Methods:
A simulation model for ACL graft preparation was constructed using shoelace as graft material and a wooden graft preparation board that matched the dimensions of existing products. A 12-minute instructional video targeted at novice learners was created to accompany the simulation model. A prospective randomized controlled trial was conducted on orthopaedic surgery residents divided into 2 groups with equal distributions of postgraduate year (PGY) status. The intervention group learned ACL graft preparation via the Shoelace ACL Simulation Guide, whereas a control group viewed a standard instructional video. All participants then prepared an 8-strand ACL graft using allograft materials and were evaluated via a checklist of critical steps and a global assessment rating as provided by an expert blinded to group allocation. Participants’ preintervention and postintervention self-assessment scores were also collected.

Results:
Ten orthopaedic surgery residents from a single institution participated in the study, with even distributions across study groups of PGY-1, PGY-3, and PGY-4 residents. Preintervention self-assessments of knowledge and technical ability were similar between participant groups. The mean overall performance score was significantly greater in the shoelace simulation intervention group (22.6±1.5) than in the instructional video only control group (16.0±5.1) (P=0.043). Participants in the intervention group showed greater improvement in self-confidence in their technical ability than those in the control group (P=0.012). Groups demonstrated similar postintervention improvements in self-reported knowledge of ACL graft preparation (P=0.128). All participants who learned via the Shoelace ACL Simulation Guide strongly agreed that they would use the learning tool to prepare for ACL reconstruction surgery.

Conclusions:
A self-directed low-cost simulation model for soft tissue ACL graft preparation utilizing shoelaces resulted in improved performance metrics compared with standard video instruction. The teaching model may be incorporated easily and inexpensively into simulation curricula at other training programs.

Level of Evidence:
Level II—therapeutic study.
Hydroa Vacciniforme–Like T-Cell Lymphoma: A Further Brazilian Case
Authors: Miranda Mario Fernando Ribeiro de , Santos Josie Eiras Bisi dos , Müller Silvia Ferreira Rodrigues , Bittencourt Maraya de Jesus Semblano , Brito Arival Cardoso de , Barros Junior Jorge Nazareno da Silva , Xerfan Ellen Maria Sampaio 
Published: March 2017

Abstract:
Hydroa vacciniforme (HV)–like lymphoma is a rare, usually fatal Epstein–Barr virus–driven lymphoproliferative disease affecting children from Asia, Mexico, and South America. Cutaneous manifestations imitate HV, a benign photodermatosis in which systemic symptoms are not observed, and spontaneous regression occurs later in adolescence or young adulthood. We report a case of HV-like lymphoma in a 12-year-old girl, descendent from an ancient Amazon indigenous tribe that, as far as we know, represents the second Brazilian case ever reported in the medical literature.
Intraepithelial Melanoma in the Stomach After Treatment With Immune Checkpoint Blockade Therapy
Authors: Shustef Elina , Torres-Cabala Carlos A. , Curry Jonathan L. , Tetzlaff Michael T. , Nagarajan Priyadharsini , Ivan Doina , Prieto Victor G. , Aung Phyu P. 
Published: March 2017

Abstract:
Melanoma is the most common tumor to metastasize to the gastrointestinal tract, commonly affecting the small intestine, colon, and anorectum. Primary mucosal melanoma can arise in any gastrointestinal site, most frequently affecting anorectal mucosa. Melanoma involving the gastric mucosa, specifically, is exceedingly rare and carries a poor prognosis with a median survival of 5 months. The presence of atypical melanocytes exclusively within gastric epithelium has not been previously described. We report a case of a 52-year-old man with widespread BRAFV600E mutant metastatic melanoma who was referred to our institution for immune checkpoint antibody-blockade therapy. The patient had previously been treated with BRAF inhibitors, and despite initial response to therapy, developed resistance leading to disease progression and multiorgan involvement including the liver, spleen, and axial skeleton. Immune checkpoint antibody blockade with ipilimumab and pembrolizumab has been shown to induce significant tumor regression in patients with melanoma by upregulating T-cell activity and removing the natural check on the host immune response. After his first dose of combination therapy, the patient underwent an upper gastrointestinal tract endoscopy for severe nausea and was found to have 2 pigmented lesions within the gastric body, one of which was biopsied. The biopsy showed gastric body-fundic type mucosa with melanophages and scattered atypical intraepithelial melanocytes within the lamina propria, which were strongly positive for S100, HMB45, SOX10, and MITF. A Fontana-Masson silver stain was performed for confirmation. The finding of predominantly atypical intraepithelial melanocytes associated with melanin pigment was interpreted as metastatic melanoma to the stomach with some regression in response to immune checkpoint blockade therapy.
RETINAL VASCULAR ABNORMALITIES IN A LARGE COHORT OF PATIENTS AFFECTED BY NEUROFIBROMATOSIS TYPE 1
Authors: Parrozzani Raffaele , Pilotto Elisabetta , Clementi Maurizio , Frizziero Luisa , Leonardi Francesca , Convento Enrica , Miglionico Giacomo , Pulze Serena , Perrini Pierdavide , Trevisson Eva , Cassina Matteo , Midena Edoardo 
Published: March 2017

Purpose:
To evaluate the prevalence, the vascular features, and the clinical diagnostic implication of retinal vascular abnormalities (RVAs) associated with neurofibromatosis Type 1 (NF1) in a large cohort of patients.

Methods:
Two hundred and ninety-four patients affected by NF1 were consecutively enrolled. The presence of RVAs was detected by means of infrared confocal scanning laser ophthalmoscopy images. Three hundred age- and race-matched healthy subjects were enrolled as a healthy control group. Fluorescein angiography, indocyanine green angiography, and optical coherence tomography angiography were also performed in patients with RVAs.

Results:
Retinal vascular abnormalities were detected in 18 patients with NF1 (6.1%) and in none of the healthy subjects. Retinal vascular abnormalities appeared in all cases as well-defined, small, tortuous retinal vessels with a spiral aspect, originating from small tributaries of retinal veins. The presence of RVAs did not correlate with the presence of other specific ocular or systemic NF1 features (P > 0.05). On optical coherence tomography angiography, RVAs appeared as an isolated tortuous vessel of the superficial vascular plexus in all cases, associated with localized anomalous crowded and congested capillary network of the deep vascular plexus in 75% of cases.

Conclusion:
Retinal vascular abnormalities are present in a limited proportion of patients affected by NF1 and can be considered an additional distinctive sign of the disease.
CLINICALLY INVISIBLE RETINOBLASTOMA RECURRENCE IN AN INFANT
Authors: Park Krystal , Sioufi Kareem , Shields Carol L. 
Published: March 2017

Purpose:
To report a case of clinically invisible retinoblastoma recurrence detected only on spectral-domain optical coherence tomography.

Methods:
Case report.

Results:
A 3-week-old girl with bilateral familial retinoblastoma underwent six cycles of intravenous chemoreduction. Both eyes showed tumor regression. After 6 cycles of chemoreduction, the tumor in the right eye appeared with clinical regression; however, by spectral-domain optical coherence tomography, there was 40 μm increase in thickness and 290 μm increase in basal diameter. Due to tumor proximity of 1.85 mm to the foveola, the recurrence was treated via intraarterial chemotherapy with two cycles of Melphalan 3 mg. After treatment, spectral-domain optical coherence tomography showed complete regression of the recurrent tumor to a flat scar with intact fovea.

Conclusion:
Precise submillimeter imaging with spectral-domain optical coherence tomography for monitoring retinoblastoma is important and can allow detection of early recurrences that might be clinically invisible otherwise, as well as surveillance of the fovea.
CENTRAL RETINAL VEIN OCCLUSION IN GATA2 DEFICIENCY
Authors: Berry Duncan , Fekrat Sharon 
Published: March 2017

Purpose:
To examine the association between GATA2 deficiency–related myelodysplastic syndrome (MDS) and central retinal vein occlusion (CRVO).

Methods:
Clinical ophthalmologic examination and laboratory work-up was performed for a patient with GATA2 deficiency–related MDS who experienced a unilateral CRVO. The literature was reviewed for reports of CRVO in the setting of MDS and allogeneic hematopoietic stem cell transplantation.

Results:
Ophthalmologic examination revealed findings consistent with unilateral CRVO. Typical hypercoagulable work-up did not reveal an identifiable cause. A review of the patient's medical history revealed multiple potential causes of CRVO, including drug-induced and/or related to her history of MDS and hematopoietic stem cell transplantation. The literature was reviewed for reports of CRVO in association with her risk factors.

Conclusion:
On review of the literature, we determined that GATA2 deficiency–related MDS was a possible cause of this patient's CRVO although it is likely that her multiple risk factors worked synergistically to create a prothrombotic state. This case and review of the literature serve as an important reminder of the long and ever-evolving list of risk factors for the development of CRVO.
ACUTE IDIOPATHIC MACULOPATHY: 7-YEAR FOLLOW-UP WITH DEVELOPMENT OF OUTER RETINAL TUBULATIONS
Authors: Heymann Hans B. , Colon Daniel A. , Jampol Lee M. 
Published: March 2017

Purpose:
To describe the development of outer retinal tubulations in a patient with acute idiopathic maculopathy.

Methods:
Chart review was performed on a single patient to collect all relevant clinical information and diagnostic imaging.

Results:
A case of outer retinal tubulations in a patient with idiopathic maculopathy is documented.

Conclusion:
Patients with acute idiopathic maculopathy may develop outer retinal tubulations similar to other entities that cause disturbance of retinal pigment epithelium or photoreceptors.
Testicular growth and development in puberty
Authors: Koskenniemi Jaakko J. , Virtanen Helena E. , Toppari Jorma 
Published: March 2017

Purpose of reviewTo describe pubertal testicular growth in humans, changes in testicular cell populations that result in testicular growth, and the role of testosterone and gonadotrophins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in testicular growth. When human data were not available, studies in nonhuman primates and/or rodents were used as surrogates.Recent findingsTesticular growth in puberty follows a sigmoidal growth curve, with a large variation in timing of testicular growth and adult testicular volume. Testicular growth early in puberty is due to increase in Sertoli cell number and length of seminiferous tubules, whereas the largest and fastest growth results from the increase in the diameter of the seminiferous tubules first due to spermatogonial proliferation and then due to the expansion of meiotic and haploid germ cells. FSH stimulates Sertoli cell and spermatogonial proliferation, whereas LH/testosterone is mandatory to complete spermatogenesis. However, FSH and LH/testosterone work in synergy and are both needed for normal spermatogenesis.SummaryTesticular growth during puberty is rapid, and mostly due to germ cell expansion and growth in seminiferous tubule diameter triggered by androgens. Pre-treatment with FSH before the induction of puberty may improve the treatment of hypogonadotropic hypogonadism, but remains to be proven.
Current Approach to the Diagnosis and Emergency Department Management of Appendicitis in Children
Authors: Lipsett Susan C. , Bachur Richard G. 
Published: March 2017

Abstract
Concerns about radiation exposure have led to a decrease in the use of computed tomography in suspected appendicitis, with increased reliance on ultrasound. Children with suspected appendicitis should be risk stratified using a combination of clinical signs and symptoms, white blood cell count, and ultrasound in order to guide further evaluation and management. Magnetic resonance imaging is a promising imaging modality but remains costly. Ongoing research is evaluating the role of nonoperative management in children with confirmed appendicitis.