bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beam and tissue factors affecting Cherenkov image intensity for quantitative entrance and exit dosimetry on human tissue
Authors: Zhang Rongxiao , Glaser Adam K. , Andreozzi Jacqueline , Jiang Shudong , Jarvis Lesley A. , Gladstone David J. , Pogue Brian W. 
Published: August 2016

This study's goal was to determine how Cherenkov radiation emission observed in radiotherapy is affected by predictable factors expected in patient imaging. Factors such as tissue optical properties, radiation beam properties, thickness of tissues, entrance/exit geometry, curved surface effects, curvature and imaging angles were investigated through Monte Carlo simulations. The largest physical cause of variation of the correlation ratio between of Cherenkov emission and dose was the entrance/exit geometry (˜50%). The largest human tissue effect was from different optical properties (˜45%). Beyond these, clinical beam energy varies the correlation ratio significantly (˜20% for X‐ray beams), followed by curved surfaces (˜15% for X‐ray beams and ˜8% for electron beams), and finally, the effect of field size (˜5% for X‐ray beams). Other investigated factors which caused variations less than 5% were tissue thicknesses and source to surface distance. The effect of non‐Lambertian emission was negligible for imaging angles smaller than 60 degrees. The spectrum of Cherenkov emission tends to blue‐shift along the curved surface. A simple normalization approach based on the reflectance image was experimentally validated by imaging a range of tissue phantoms, as a first order correction for different tissue optical properties.
magnified image
A method for nondestructive mechanical testing of tissues and implants
Authors: Shah Ruchit , Pierce Mark C. , Silver Frederick H. 
Published: August 2016

AbstractNumerous tests have been used to elucidate mechanical properties of tissues and implants including tensile, compressive, shear, hydrostatic compression, and three‐point bending in one or more axial directions. The development of a nondestructive test that could be applied to tissues and materials in vivo would promote the analysis of tissue pathology as well as the design of implant materials. The purpose of this article is to present the results of preliminary studies demonstrating nondestructive in vitro testing of a tissue model, decellularized human dermis, and a model implant, silicone rubber, using a combination of optical coherence tomography (OCT), and vibrational analysis. The results presented suggest that nondestructive vibrational testing of tissues and materials can be used to determine the modulus of polymeric materials and the results are similar to those found using tensile stress‐strain measurements. The advantage of this method is that the modulus can be obtained from vibrational methods without having to approximate the tangent to the stress−strain curve, which is difficult for nonlinear materials that have a rapidly changing slope. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 15–22, 2017.
A large‐scale analysis of alternative splicing reveals a key role of QKI in lung cancer
Authors: de Miguel Fernando J. , Pajares María J. , Martínez-Terroba Elena , Ajona Daniel , Morales Xabier , Sharma Ravi D. , Pardo Francisco J. , Rouzaut Ana , Rubio Angel , Montuenga Luis M. , Pio Ruben 
Published: August 2016

Increasing interest has been devoted in recent years to the understanding of alternative splicing in cancer. In this study, we performed a genome‐wide analysis to identify cancer‐associated splice variants in non‐small cell lung cancer. We discovered and validated novel differences in the splicing of genes known to be relevant to lung cancer biology, such as NFIB, ENAH or SPAG9. Gene enrichment analyses revealed an important contribution of alternative splicing to cancer‐related molecular functions, especially those involved in cytoskeletal dynamics. Interestingly, a substantial fraction of the altered genes found in our analysis were targets of the protein quaking (QKI), pointing to this factor as one of the most relevant regulators of alternative splicing in non‐small cell lung cancer. We also found that ESYT2, one of the QKI targets, is involved in cytoskeletal organization. ESYT2‐short variant inhibition in lung cancer cells resulted in a cortical distribution of actin whereas inhibition of the long variant caused an increase of endocytosis, suggesting that the cancer‐associated splicing pattern of ESYT2 has a profound impact in the biology of cancer cells. Finally, we show that low nuclear QKI expression in non‐small cell lung cancer is an independent prognostic factor for disease‐free survival (HR = 2.47; 95% CI = 1.11–5.46, P = 0.026). In conclusion, we identified several splicing variants with functional relevance in lung cancer largely regulated by the splicing factor QKI, a tumor suppressor associated with prognosis in lung cancer.
A Cost Analysis of Salbutamol Administration by Metered-Dose Inhalers with Spacers versus Nebulization for Patients with Wheeze in the Pediatric Emergency Department: Evidence from Observational Data in Nova Scotia
Authors: Spin Paul , Sketris Ingrid , Hill-Taylor Barbara , Ward Courtney , Hurley Katrina F. 
Published: August 2016

AbstractBackgroundDespite evidence demonstrating the advantages of metered-dose inhalers with spacers (MDI-s), nebulization (NEB) remains the primary method of asthma treatment in some pediatric emergency departments (PEDs). There is a perception that delivering salbutamol by MDI-s is more costly than by NEB. This research evaluates the relative costs of MDI-s and NEB using local, hospital-specific, patient-level data.MethodsRegression models estimated associations between the salbutamol inhalation method and costs, length of stay (LOS) in the PED and hospital, and the probability of admission. Our population was a random sample of 822 patients presenting with wheeze to the PED in 2008/2009. Control variables included age, sex, triage acuity, time of PED visit, other medications, and vitals. Costs were calculated using the prices and quantities of medical resources used per treatment. Probabilistic sensitivity analysis was used.ResultsTreatment with MDI-s versus NEB was associated with an absolute decrease in hospitalization of 4.4% (p<0.05) and a 25-hour (p<0.001) reduction in average inpatient stay, after controlling for triage acuity and patient characteristics. This resulted in savings of $24/patient in the PED and $180/patient overall (p<0.001). Inpatient care accounted for more than 90% of total patient costs.ConclusionsOur results suggest economic gains associated with MDI-s for salbutamol inhalation in PEDs. Sensitivity analyses show that this conclusion is not affected by changes in model parameters that may differ by jurisdiction. Since most facilities already collect the data used for this study, our methods could be adopted for a cross-jurisdictional account of the cost effectiveness of MDI-s.
Maori Hill-Forts
Authors: Firth Raymond 
Published: August 2016

Many a wanderer through the country districts of New Zealand has found interest in the sight of the monumental earthworks which crown so many of our hills. There is something grand and yet pathetic about these old fortresses. Once the scene of turmoil and activity, they now lie neglected and still beneath the sky, clothed in bush, or scrub, or fern, or grass-grown and dotted with sheep. Their day is over, the Maori long since has ceased to swarm on their slopes and man their palisades; they are but a memory of the warring and the peacemaking, the fighting and the feasting of the eventful past.In this paper it is my object to give a brief account of the general features of their construction and of their importance in Maori life.
Ithaka
Authors: Shewan Alexander 
Published: August 2016

The island of Ithaka in the Ionian Sea has been famous throughout the centuries that have passed since European literature began with Homer. In itself it is small and mountainous, and but a poor spot on which to stage a noble drama, but its association with the far-famed hero of an immortal epic has more than made up for the insignificance of the terrain. In recent years it has achieved further distinction as the subject of a lively, and at times embittered controversy about its actual position on the map. Most scholars are content to believe that by Ithaka Homer meant the island which still bears the name, now modified to Thiaki; others affirm that the scene of the poet's story was really Santa Maura to the north, while others again have given the honour to Cefalonia to the west. Quite recently a German geographer has even proclaimed that ‘Corfu is Ithaka.’ Samuel Butler, in his famous Homeric escapade, convinced himself that Ithaka was to be found in one of the Aegadean Islands off the coast of Sicily. So far, it has not been said of it that it never existed save in the imagination of the poet, but it may yet be the victim of that last infirmity of Homeric geographical speculation.Interest in the island due to certain observations by the ancients was quickened by the visits of travellers-Gell, Dodwell, Leake, Mure and others-in the course of last century. The general aim of their explorations was to test the correctness of the Odyssean descriptions, and this they did with thoroughness. Their fault was that generally they went too far; they expected, and sought to establish, perfect correspondence. The modern expert comments that a poet is a poet; that freedom in his dealings with time and space is only his right; and that trifling discrepancies between the poetry and actuality are not to be regarded as vitiating the whole description and stamping it as purely imaginary. And all that may be conceded. The old explorers were certainly the victims of an excess of zeal. It has even been said that the inhabitants of the island made profit of their eagerness, by inventing names of localities to do duty as the remains of the appellations to be found in the epic.
Notes on the Types of English Villages and their Distribution
Authors: Page William 
Published: August 2016

Little has been done towards solving the problem of the Saxon settlement of England by studying the types of villages and their distribution. Professor Maitland saw the importance of the subject and pointed out how valuable in this respect was the ordnance map ‘that marvellous palimpsest which under Dr Meitzen's guidance we are beginning to decipher’. Helpful, however, as the ordnance maps are, they cannot be read alone, a knowledge of the archaeology, history and topography of the district under review is a necessary equipment for such an investigation. The remarks here made are tentative and are offered in the hope they may be an incentive to others with local knowledge to examine the evidence of their districts.Professor Maitland, following Dr. Meitzen and others, has adopted two main types of settlements, namely, the scattered or dispersed, and the nucleated or clustered. These two types probably comprehend all forms of settlements, but certainly the nucleated type and possibly the scattered type, show many variants which it may be well to indicate before a methodical study of the subject can be made. I have elsewhere suggested the following classification of English towns and villages which will no doubt require modification and amplification but may meet a want for a preliminary inquiry; (I) scattered or dispersed settlements, (2) nucleated or clustered settlements off lines of communication, (3) nucleated settlements on lines of communication, (4) ring-fence settlements, (5) towns with bridge heads and double towns, (6) towns of gridiron plan, (7) towns of spider's web plan, (8) Bastide towns. Except for the first of these classes all of them are nucleated or clustered, and to this wider division I propose to devote my attention. It may perhaps be pointed out, however, that the scattered or dispersed settlements occur chiefly in Wales and in the west and north of England. They are found throughout Cornwall, in Devon, Somerset and the open parts of the Welsh border counties, in Yorkshire and Derbyshire, and probably they are the origin of the great parishes with their numerous townships of the other northern counties. They were adapted for a pastoral people and are generally to be found in moorland or mountainous country which has become divided into large parishes. They consist of hamlets and single houses or small groups of houses scattered somewhat promiscuously throughout a district. The principal hamlet from which the settlement or parish takes its name-which was probably the meeting place of the district and where the church was eventually placed-was generally on high land or a main road and frequently at cross roads, bridges, or such like places of nodality.
Roman Malton: a Yorkshire Fortress and its neighbourhood*
Authors: Corder Philip , Kirk John L. 
Published: August 2016

Except for some trenches dug in 1865-6, when the Thirsk and Malton railway was constructed, no systematic excavation of the Roman station at Malton has ever been made until 1927. Although casual Roman finds have been plentiful, few of them have been published and little is definitely known about the site and its history, the current Ordnance Survey map merely marking the Fortress as ‘Supposed Roman Camp’. Many of the statements made about it in the past have been purely conjectural. As a result of recent investigations, the writers believe that the time has come when some general statement can profitably be made as to the extent of the site, its importance in Roman times, and the nature of the occupation of the neighbourhood.Amongst those who have written of the antiquities of Malton in the past, one writer, Rev Dr Young (History of Whitby, 1817) shows unusual judgment and penetration in an age when antiquaries were only too ready to repeat the guesses of their predecessors. The exact position and extent of the Malton fort were unknown before 1927, and few finds are recorded before the 19th century, yet Dr Young recognized it as a place of importance and guessed its position correctly.
Rock-pictures and Archaeology in the Libyan Desert
Authors: Newbold D. 
Published: August 2016

Out of Africa there is always something new, as Aristotle wrote in the fourth century B.C., and although the Libyan Desert is one of the most desolate areas of the world’s surface, recent explorations have shown that there are many archaeological discoveries to be made which will throw considerable light on the early history of peoples and their migrations in North Africa.In the eastern Sahara and in the Libyan Desert, there are still many unexplored tracts, and even, it is probable, several unvisited oases, particularly in the great white spaces on the map which stretch southwest and southeast of the Kufara oasis-group.
Climate and Migrations
Authors: Curry J. C. 
Published: August 2016

In separate favoured regions various kinds of men set out to domesticate and master the gifts and forces around them: to ‘live well’, in the old Greek phrase, under the given conditions of their home, or failing this, to seek and make a new one: in either event, to comply as well as to command; to conquer Nature by observance of her laws. J. L. MyresIn this wonderful century when discoveries and inventions have followed fast on one another’s heels Man seems to look dazed and half comprehendingly at the works of his own hands. So that there are some who say that he is on the brink of new andmore wonderful mastery over Nature ; others that there are no more discoveries to make ; and others again who wish to cry halt, and ask, hopelessly, for ten years’rest from the innovations and disturbances which scientific inquiry is bringing into their world.
The Sahara
Authors: Bovill E. W. 
Published: August 2016

The history of North Africa is dominated by the Sahara, which has always been a vital factor in the lives of the peoples of Barbary and the Western Sudan. The cultural and economic development of both has been profoundly affected by intercourse between the two. Yet they are separated by a desert which forms one of the world's greatest barriers to human intercourse.A slight increase in the aridity of the Sahara would so extend the waterless stages that the caravan routes would become impassable to camels and therefme to men—leaving, of course, mechanical transport out of consideration. A correspondingly slight increase in rainfall would quickly multiply the waterholes and desert pastures and render man independent of the now necessary camel. The question of climatic change in historic times is therefore a matter of importance to the student of the history of northern Africa.
‘Fossil Tradition’ in Stone Implements
Authors: de Pradenne A. Vayson 
Published: August 2016

When one speaks of tradition, that is to say, of the transmission of human knowledge from one generation to another, one implies that there are two methods by which that transmission is effected—the spoken and the written word; thus one draws a distinction between oral and written tradition.Nowadays written tradition alone is of importance; but one recognizes that it has gradually replaced that oral tradition which alone existed, as one supposes, in prehistoric times. We wish here to call attention to yet another mode of transmission which certainly played a part, perhaps even an important part, in the Stone Ages, and disregard of which might in certain instances seriously confuse the study of prehistoric archaeology.
The Method of Prehistoric Archaeology
Authors: Tallgren A. M. 
Published: August 2016

During the last fifty years prehistoric archaeology has developed with extraordinary rapidity into a firmly established branch of science. A system has been constructed, the frontiers of several cultural phenomena have been laid down, and the outlines of prehistoric chronology have been formed. Hypotheses and assertions have been made concerning the ethnographical groups of prehistoric times, and lengthy ‘prehistoric’ periods have literally been transformed into ‘historic’ ones. The inscription on the medal struck for Oscar Montelius– ‘Fifty years of research have mastered millennia of human culture ’ –may serve as a short motto summarizing the results of archaeology as a whole, not merely the achievements of one man.The method which has led to this result is that of the empiric sciences, based on the theory of evolution, namely, that of typology. The starting-point of research has for the most part been morphology. When synthesis has been the objective, the student’s instruments of research have consisted primarily of forms or shapes of objects, or ornaments and tombs and so forth, and their comparison.
The Syrian City of Til-Barsib
Authors: Mallowan M. E. L. 
Published: August 2016

TIl-BArsib. Par F. Thureau-Dangin et Maurice Dunand avec le concours de Lucien Cavro et Georges Dossin. Paris: Paul Geuthner, 1936. pp. 166 with Album of 53 plates and 5 plans. 200 francs.This volume is a most important contribution to the archaeology of Syria. Tell-’Ahmar, which lies on the left bank of the Euphrates, 20 kilometres below Carchemish, marks the site of the ancient city of Til-Barsib. As long ago as 1908 the late Dr Hogarth had suggested the identification of this mound with Barsib, and in 1911 Dr Campbell Thompson proved the correctness of Hogarth’s surmise by copying and translating an Assyrian inscription which lay on the mound. After making preliminary soundings in 1927 a French Expedition under the auspices of the MusCe du Louvre set to work in 1929 and the excavations, involving a total of seven months’ work in all, were concluded in 1931. This volume, lavishly illustrated, describes in detail the remarkable results.
A 6th century German Settlement of foederati
Authors: Bersu Gerhard 
Published: August 2016

In the fertile region between the Danube and the Balkans occur numerous Byzantine fortified posts, which are shown by occasional finds of coins to date mostly from the sixth century. All have a common form in that skilful use has been made of natural features of terrain, such as isolated mountain-tops or practically isolated spurs, so that with a minimum cf artificial strengthening they have considerable defensive power. A favourite situation for them is at points where narrow canyon-like valleys of the streams that flow into the Danube have afforded good natural advantages.From the military standpoint these sites can easily be divided into two groups, A and B, according to their topographical situation. To the first belong those which occur on the great natural trade-routes, and, like a modern Sperrfort, rake the roads with a commanding view over the surrounding district. The second and much more numerous group consists of posts situated off the trade-routes, often so much concealed by the lie of the land as to be invisible from the great roads.
La date des kourganes de Trialeti
Authors: Schaeffer C. F. A. 
Published: August 2016

Les étonnantesm trouvailles retirées par la mission russe de Tsalka (direction B. A. Kuftin) des grands tertres funéraires ou kourganes de la vallée supérieure de la Khram dans la province de Trialeti, Géorgie centrale, à l'Ouest de Tiflis (1), ont causé une sensation dans le monde des archéologues (2). Comme, à l'occasion d'une étude d'ensemble sur la chronologie du Bronze au Caucase (3), nous venons d'étudier ces nouvelles trouvailles, il nous paraît utile de publier ici nos conclusions relatives à la date qu‘;il convient d'attribuer au kourganes de Trialeti. La question, en effet, intéresse au plus haut point l'archéologie du Caucase.Disons tout de suite que Mr. Kuftin considère l'époque de la quatrième tombe à fosse de Mycènes et celle de Troie vi comme le terminus post quem des plus récentes des kourganes qu'il classe à la fin du Bronze Moyen. Il ne croit pas devoir envisager pour eux une date postérieure aux xvue siècle avant notre ère, tandis que nous serions en faveur d'une attribution de l'ensemble de ces kourganes aux xvie-xve s., c'est-à-dire au début du Bronze Récent.
Canterbury Excavations, 1944–8
Authors: Frere Sheppard 
Published: August 2016

On 1 June 1942, occurred the German air-raid which destroyed about one-fifth of the old part of the City of Canterbury. It was soon realized that a unique opportunity existed of discovering something of the archaeological past of the city before rebuilding again concealed the wide areas now exposed.It was not only an opportunity but a duty ; for modern rebuilding, with its deep foundations, would be bound to destroy a very large part of whatever evidence had survived until the present. The Canterbury Excavations Committee was accordingly formed by the initiative of the local Archaeological Society, and excavations under a supervisor lent by the Ministry of Works began in August 1944, and have continued three times a year up to the present.Canterbury is one of the few Romano-British towns where there are good grounds for supposing a continuity of occupation through the Dark Ages. Thus though there was little to hint at any pre-Roman occupation, from the Roman, Saxon, and Medieval periods much was to be expected. Yet such a prediction has not turned out wholly true. On the one hand evidence for a pre-Roman Belgic settlement is accumulating ; but little of Saxon date has been found, and the circumstances of the excavations have limited the extent of the medieval discoveries.The town could not be investigated purely as an archaeological problem, digging on sites which seemed promising and following out the plan as on an open site like Silchester or Verulam. There was a double call. Rebuilding was ever imminent, and the first sites to be rebuilt were likely to be along the main street-frontages. Attention was necessarily devoted first to them.