bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regioselective Synthesis of Angular Isocoumarinselenazoles: A Benzoselenazole‐directed, Site‐specific, Ruthenium‐catalyzed C(sp2)‐H Activation
Authors: Dhole Sandip , Liao Jen‐Yu , Kumar Sunil , Salunke Deepak B. , Sun Chung‐Ming 
Published: January 2018

AbstractThe synthesis of new, angular isocoumarinselenazoles is described, which involves the construction of 2‐amino benzoselenazoles and their regioselective C2N‐alkylation and alkyne insertion. An expeditious and metal‐free synthesis of 2‐aminobenzoselenazoles by the reaction of methyl 3‐amino‐4‐fluorobenzoate and isoselenocyanates was achieved. Further N‐alkylation of the 2‐aminobenzoselenazoles resulted the formation of two regioisomers with different reactivities towards the alkyne insertion. The regioselective construction of the α‐pyrone ring on the benzo[1,3‐d]selenazole skeleton was achieved via a ruthenium (II)‐catalyzed oxidative annulation. It is clear that the selenazole nitrogen plays an important role in the observed selectivity.magnified image
Prediction of part geometry‐dependent weld line strength in unreinforced polycarbonate
Authors: Hopmann Christian , Onken Jakob 
Published: January 2018

AbstractTo predict the mechanical properties of weld lines in injection‐molded unreinforced amorphous plastics parts, an integrative calculation chain has been developed. Weld lines created by different flow obstacle geometries were characterized through mechanical testing. A strong dependence of the weld line strength on the geometry of the flow obstacle and the distance to the flow obstacle, which causes the weld line, was observed. Further, a dependence of the weld line strength on the loading direction was noted. These results were used to establish a simulation routine which is based on a physical description of molecular interdiffusion and uses the melt confluence angles in the weld line to determine weld line annealing behind flow obstacles. The calculated breaking stress of weld lines in polycarbonate using the model deviates on average 14% from the fracture stress that was determined experimentally.
Engineering a Tumor Microenvironment‐Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells
Authors: Wang Zhenzhen , Wang Chunming , Abudukeremu Ayipaxia , Rui Xiaying , Liu Shang , Zhang Xiaoyi , Zhang Min , Zhang Junfeng , Dong Lei 
Published: January 2018

AbstractThe insufficient number of cells suitable for transplantation is a long‐standing problem to cell‐based therapies aimed at tissue regeneration. Xenogeneic cancer cells (XCC) may be an alternative source of therapeutic cells, but their transplantation risks both immune rejection and unwanted spreading. In this study, a strategy to facilitate XCC transplantation is reported and their spreading in vivo is confined by constructing an engineering matrix that mimics the characteristics of tumor microenvironment. The data show that this matrix, a tumor homogenate‐containing hydrogel (THAG), successfully creates an immunosuppressive enclave after transplantation into immunocompetent mice. XCC of different species and tissue origins seeded into THAG survive well, integrated with the host and developed the intrinsic morphology of the native tissue, without being eliminated or spreading out of the enclave. Most strikingly, immortalized human hepatocyte cells and rat β‐cells loaded into THAG exert the physiological functions of the human liver and rat pancreas islets, respectively, in the mouse body. This study demonstrates a novel and feasible approach to harness the unique features of tumor development for tissue transplantation and regenerative medicine.
A Free‐Standing High‐Output Power Density Thermoelectric Device Based on Structure‐Ordered PEDOT:PSS
Authors: Li Zaifang , Sun Hengda , Hsiao Ching‐Lien , Yao Yulong , Xiao Yiqun , Shahi Maryam , Jin Yingzhi , Cruce Alex , Liu Xianjie , Jiang Youyu , Meng Wei , Qin Fei , Ederth Thomas , Fabiano Simone , Chen Weimin M. , Lu Xinhui , Birch Jens , Brill Joseph W. , Zhou Yinhua , Crispin Xavier , Zhang Fengling 
Published: January 2018

AbstractA free‐standing high‐output power density polymeric thermoelectric (TE) device is realized based on a highly conductive (≈2500 S cm−1) structure‐ordered poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate film (denoted as FS‐PEDOT:PSS) with a Seebeck coefficient of 20.6 µV K−1, an in‐plane thermal conductivity of 0.64 W m−1 K−1, and a peak power factor of 107 µW K−2 m−1 at room temperature. Under a small temperature gradient of 29 K, the TE device demonstrates a maximum output power density of 99 ± 18.7 µW cm−2, which is the highest value achieved in pristine PEDOT:PSS based TE devices. In addition, a fivefold output power is demonstrated by series connecting five devices into a flexible thermoelectric module. The simplicity of assembling the films into flexible thermoelectric modules, the low out‐of‐plane thermal conductivity of 0.27 W m−1 K−1, and free‐standing feature indicates the potential to integrate the FS‐PEDOT:PSS TE modules with textiles to power wearable electronics by harvesting human body's heat. In addition to the high power factor, the high thermal stability of the FS‐PEDOT:PSS films up to 250 °C is confirmed by in situ temperature‐dependent X‐ray diffraction and grazing incident wide angle X‐ray scattering, which makes the FS‐PEDOT:PSS films promising candidates for thermoelectric applications.
Synergetic Protective Effect of the Ultralight MWCNTs/NCQDs Modified Separator for Highly Stable Lithium–Sulfur Batteries
Authors: Pang Ying , Wei Jishi , Wang Yonggang , Xia Yongyao 
Published: January 2018

AbstractLithium–sulfur (Li–S) batteries are highly attractive due to their high energy density, potentially low cost, and environmental compatibility. However, their commercialization has been greatly hindered by their poor cycle life and severe self‐discharge, which can be attributed to the polysulfides dissolution. To overcome these issues, much effort has been devoted to engineering the electrode structure and composition to improve the performance which is often expensive and laborious. In this study, an ultralight multiwall carbon nanotube/N‐doped carbon quantum dot (MWCNT/NCQD)‐coated separator is first designed, which is cost effective and facile. The MWCNTs/NCQDs‐coated separator is then applied in Li–S batteries. The MWCNTs/NCQDs coating provides a physical shield against polysulfide shuttling and chemical adsorption of polysulfides by MWCNTs and NCQDs. The synergetic effect of MWCNTs and NCQDs enables the production of Li–S cell with a relative high initial discharge capacity of 1330.8 mA h g−1 and excellent cyclic performance with a corresponding capacity fade rate of as low as 0.05% per cycle at 0.5 C over 1000 cycles. Excellent rate capability and anti‐self‐discharge behavior are also displayed. The design of MWCNTs/NCQDs‐coated separator is a viable approach for successfully developing practical Li–S batteries.
Sodium Ion Stabilized Vanadium Oxide Nanowire Cathode for High‐Performance Zinc‐Ion Batteries
Authors: He Pan , Zhang Guobin , Liao Xiaobin , Yan Mengyu , Xu Xu , An Qinyou , Liu Jun , Mai Liqiang 
Published: January 2018

AbstractAqueous Zn‐ion batteries (ZIBs) have received incremental attention because of their cost‐effectiveness and the materials abundance. They are a promising choice for large‐scale energy storage applications. However, developing suitable cathode materials for ZIBs remains a great challenge. In this work, pioneering work on the designing and construction of aqueous Zn//Na0.33V2O5batteries is reported. The Na0.33V2O5(NVO) electrode delivers a high capacity of 367.1 mA h g−1at 0.1 A g−1, and exhibits long‐term cyclic stability with a capacity retention over 93% for 1000 cycles. The improvement of electrical conductivity, resulting from the intercalation of sodium ions between the [V4O12]nlayers, is demonstrated by single nanowire device. Furthermore, the reversible intercalation reaction mechanism is confirmed by X‐ray diffraction, Raman, X‐ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy analysis. The outstanding performance can be attributed to the stable layered structure and high conductivity of NVO. This work also indicates that layered structural materials show great potential as the cathode of ZIBs, and the indigenous ions can act as pillars to stabilize the layered structure, thereby ensuring an enhanced cycling stability.
Jabuticaba‐Inspired Hybrid Carbon Filler/Polymer Electrode for Use in Highly Stretchable Aqueous Li‐Ion Batteries
Authors: Song Woo‐Jin , Park Jeonghwan , Kim Dong Hyup , Bae Sohyun , Kwak Myung‐Jun , Shin Myoungsoo , Kim Sungho , Choi Sungho , Jang Ji‐Hyun , Shin Tae Joo , Kim So Youn , Seo Kwanyong , Park Soojin 
Published: January 2018

AbstractStretchable electronics are considered as next‐generation devices; however, to realize stretchable electronics, it is first necessary to develop a deformable energy device. Of the various components in energy devices, the fabrication of stretchable current collectors is crucial because they must be mechanically robust and have high electrical conductivity under deformation. In this study, the authors present a conductive polymer composite composed of Jabuticaba‐like hybrid carbon fillers containing carbon nanotubes and carbon black in a simple solution process. The hybrid carbon/polymer (HCP) composite is found to effectively retain its electrical conductivity, even when under high strain of ≈200%. To understand the behavior of conductive fillers in the polymer matrix when under mechanical strain, the authors investigate the microstructure of the composite using an in situ small‐angle X‐ray scattering analysis. The authors observe that the HCP produces efficient electrical pathways for filler interconnections upon stretching. The authors develop a stretchable aqueous rechargeable lithium‐ion battery (ARLB) that utilizes this HCP composite as a stretchable current collector. The ARLB exhibits excellent rate capability (≈90 mA h g−1 at a rate of 20 C) and outstanding capacity retention of 93% after 500 cycles. Moreover, the stretchable ARLB is able to efficiently deliver power even when under 100% strain.
Integration of FeOOH and Zeolitic Imidazolate Framework‐Derived Nanoporous Carbon as an Efficient Electrocatalyst for Water Oxidation
Authors: Li Fei , Du Jian , Li Xiaona , Shen Junyu , Wang Yong , Zhu Yong , Sun Licheng 
Published: January 2018

AbstractAs a cost‐effective catalyst for the oxygen evolution reaction (OER), the potential use of FeOOH is hindered by its intrinsic poor electron conductivity. Here, the significant enhancement of OER activity and long‐term stability of electrodeposited FeOOH on zeolitic imidazolate framework‐derived N‐doped porous carbons (NPCs) are reported. In alkaline media, FeOOH/NPC supported on nickel foam as a 3D electrode delivers a current density of 100 mA cm−2 at a small overpotential of 230 mV and exhibits a low Tafel slope of 33.8 mV dec−1 as well as excellent durability, making it one of the most active OER catalysts. Such high performance is attributed to a combined effect of the excellent electron conductivity of NPC and the synergy between FeOOH and NiO derived from Ni substrate.
MoS2‐on‐MXene Heterostructures as Highly Reversible Anode Materials for Lithium‐Ion Batteries
Authors: Chen Chi , Xie Xiuqiang , Anasori Babak , Sarycheva Asya , Makaryan Taron , Zhao Mengqiang , Urbankowski Patrick , Miao Ling , Jiang Jianjun , Gogotsi Yury 
Published: January 2018

AbstractTwo‐dimensional (2D) heterostructured materials, combining the collective advantages of individual building blocks and synergistic properties, have spurred great interest as a new paradigm in materials science. The family of 2D transition‐metal carbides and nitrides, MXenes, has emerged as an attractive platform to construct functional materials with enhanced performance for diverse applications. Here, we synthesized 2D MoS2‐on‐MXene heterostructures through in situ sulfidation of Mo2TiC2Tx MXene. The computational results show that MoS2‐on‐MXene heterostructures have metallic properties. Moreover, the presence of MXene leads to enhanced Li and Li2S adsorption during the intercalation and conversion reactions. These characteristics render the as‐prepared MoS2‐on‐MXene heterostructures stable Li‐ion storage performance. This work paves the way to use MXene to construct 2D heterostructures for energy storage applications.
Lanthanide Complexes Supported by a Trizinc Crown Ether as Catalysts for Alternating Copolymerization of Epoxide and CO2: Telomerization Controlled by Carboxylate Anions
Authors: Nagae Haruki , Aoki Ryota , Akutagawa Shin‐nosuke , Kleemann Julian , Tagawa Risa , Schindler Tobias , Choi Gyeongshin , Spaniol Thomas P. , Tsurugi Hayato , Okuda Jun , Mashima Kazushi 
Published: January 2018

AbstractA new family of heterometallic catalysts based on trimetalated macrocyclic tris(salen) ligands and rare‐earth metals was prepared and structurally characterized. The LaZn3 system containing anionic ligands such as acetate plays a critical role in catalyzing the alternating copolymerization of cyclohexene oxide (CHO) and CO2 with a high proportion of carbonate linkages. Among the lanthanide metals, the CeZn3 system exhibits high catalytic activity with a turnover frequency (TOF) of over 370 h−1. NMR analysis of the complex and end‐group analysis of the polymer suggest that the acetate ligands are rapidly exchanged, not only among coordinated acetates, but also between coordinated acetates and added carboxylate anions. These unique properties make this the first example of telomerization for the copolymerization of CHO and CO2.
Polymer complexes. LXIX. Some divalent metal(II) polymer complexes of potentially bidentate monomer N‐[4‐(5‐methyl‐isoxazol‐3‐ylsulfamoyl)‐phenyl]‐acrylamide: Synthesis, spectroscopic characterization, thermal properties, antimicrobial agents and DNA studies
Authors: El‐Sonbati A.Z. , Diab M.A. , Morgan Sh.M. , Eldesoky A.M. , Balboula M.Z. 
Published: January 2018

Monomer of N‐[4‐(5‐methyl‐isoxazol‐3‐ylsulfamoyl)‐phenyl]‐acrylamide (HL) and some transition metal polymeric complexes of the general formula {[M(HL)(OH2)2(OCOCH3)2] xH2O}n (M = Co(II), x = 2; Ni(II), x = 3; Mn(II), x = 2) and [Cd(HL)2(OCOCH3)2] were synthesized and characterized by elemental analysis, IR, UV spectroscopy, conductance measurements, magnetic susceptibility, thermogravimetric analyses and X‐ray diffraction analysis. In all polymer complexes, the spectral data revealed that the ligand act as bidentate neutral molecule and coordinate to metal ion through enolic sulphonamide OH and isoxazol‐N. In all polymer complexes, the spectral data revealed that the ligand act as bidentate neutral molecule and coordinate to metal ion through enolic sulphonamide OH and isoxazol‐N. The molar conductance data revealed that the polymer complexes are non‐electrolytes while UV‐vis and magnetic measurements data have been shown that the polymer complexes have octahedral geometry. All the studies revealed coordination six for the metals in all the polymer complexes and octahedral structures were suggested. The inhibitive effect of HL against C38 steel was investigated in 2 M HCl solution (tafel polarization, electrochemical impedance spectroscopy (EIS) and electrochemical frequency modulation (EFM) methods). The type of HL is mixed inhibitor whose adsorption habit onto C38 steel.
Salience Versus Proportional Reasoning: Rethinking the Mechanism Behind Graphical Display Effects
Authors: Stone Eric R. , Reeder Emily C. , Parillo Jonathan , Long Cynthia , Walb LeeAnn 
Published: January 2018

AbstractTwo experiments examined predictions from two separate explanations for previously observed display effects for communicating low‐probability risks: foreground:background salience and proportional reasoning. According to foreground:background salience, people's risk perceptions are based on the relative salience of the foreground (number of people harmed) versus the background (number of people at risk), such that calling attention to the background makes the risk seem smaller. Conversely, the proportional reasoning explanation states that what matters is whether the respondent attends to the proportion, which conveys how small the risk is. In Experiment 1, we made the background more salient via color and bolding; in contrast to the foreground:background salience prediction, this manipulation did not influence participants' risk aversion. In Experiment 2, we separately manipulated whether the foreground and the background were displayed graphically or numerically. In keeping with the proportional reasoning hypothesis, there was an interaction whereby participants given formats that displayed the foreground and background in the same modality (graphs or numbers, thereby making the proportion easier to form) saw the probability as smaller and were less risk averse than participants given the information in different modalities. There was also a main effect of displaying the background graphically, providing some support for foreground:background salience. In total, this work suggests that the proportional reasoning account provides a good explanation of many display effects related to communicating low‐probability risks, although there is some role for foreground:background salience as well. Copyright © 2018 John Wiley & Sons, Ltd.
Enhanced expression of a biosimilar monoclonal antibody with a novel NS0 platform
Authors: Sampey Darryl , Courville Pascal , Acree David , Hausfeld Jeffrey , Bentley William E. 
Published: January 2018

The precise product quality and lower cost of goods demands of the growing biosimilars industry are driving biomanufacturing innovation. Biosimilar cell lines that produce complex glycoproteins such as monoclonal antibodies must be both highly productive and express a product with critical quality attributes closely matching those of the innovator reference. In this work, a biomanufacturing platform is described that harnesses the commercially‐established NS0 host cell in new ways to create stable, highly productive cell lines with characteristics meeting the current demands. A cholesterol metabolic selection marker and implementation strategy that can be generically applied are shown to yield high expressing cell lines as well as eliminate the need for cholesterol addition, which has been a significant barrier in both stainless steel reactors as well as in single‐use plastic systems. Additionally, for the first time, a multiplex selection strategy was implemented that served to increase NS0 cell line specific productivity >10‐fold and volumetric yields >6‐fold. The best overall performing cell line had a Qp of 28.5 picograms per cell per day and was rapidly adapted to a lean production medium. Yields in l‐glutamine fed‐batch shaker cultures exceeded 500 mg/L. An initial screening of four feeding strategies resulted in a final 13‐day yield of over 1.4 g/L in small shaker culture. Overall, this work shows both the strategy to develop biosimilar cell lines and the commercial potential of a novel expression system highly suited for the manufacture of biosimilars of reference biologics currently produced in murine cells. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 34:455–462, 2018
The mitochondrial calcium uniporter complex in trypanosomes
Authors: Lander Noelia , Chiurillo Miguel A. , Bertolini Mayara S. , Docampo Roberto , Vercesi Aníbal E. 
Published: December 2017

AbstractThe presence of a conserved mechanism for mitochondrial calcium uptake in trypanosomatids was crucial for the molecular identification of the mitochondrial calcium uniporter (MCU), a long‐sought channel present in most eukaryotic organisms. Since then, research efforts to elucidate the role of MCU and its regulatory elements in different biological models have multiplied. MCU is the pore‐forming subunit of a multimeric complex (the MCU complex or MCUC) and its predicted structure in trypanosomes is simpler than in mammalian cells, lacking two of its subunits and probably possessing other unidentified components. MCU protein has been characterized in Trypanosoma brucei and Trypanosoma cruzi, the causative agents of African and American trypanosomiasis, respectively. Contrary to its mammalian homolog, TbMCU was found to be essential for cell growth and survival, while its paralog MCUb is an essential protein in T. cruzi. These findings could be further exploited for chemotherapeutic purposes. The emergence of new molecular tools for the genetic manipulation of trypanosomatids has been determinant for the functional characterization of the MCUC components in these organisms. However, further research has to be done to determine the role of each component in intracellular calcium signaling and cell bioenergetics. In this mini‐review we summarize the original results on mitochondrial calcium uptake in trypanosomes, how did they contribute to the molecular identification of the MCU, and the functional characterization of the MCUC subunits that has so far been studied in these peculiar eukaryotes.
Synthesis of Co2V2O7 Hollow Cylinders with Enhanced Lithium Storage Properties using H2O2 as an Etching Agent
Authors: Wang Jinli , Pei Jian , Hua Ke , Chen Dahong , Jiao Yang , Hu Yongyuan , Chen Gang 
Published: January 2018

AbstractThe construction of hollow structures has been used as an efficient strategy to improve electrochemical properties in lithium‐ion batteries (LIBs). In this paper, novel Co2V2O7 hollow cylinders have been fabricated via a unique etching process, in which H2O2 and CO(NH2)2 were selected as the etching agent and the release rate controlling agent, respectively. The formation process for the hollow structure and the etching mechanism have been investigated. Benefiting from the improved diffusion and transport of Li+, the Co2V2O7 hollow cylinder electrode demonstrates higher electrochemical performance as an anode material for LIBs than that of Co2V2O7 solid hexagonal prisms. Under a current density of 0.4 A g−1, the cycling capacity can be improved to 2.5 times greater than that of non‐etched hexagonal prisms.
Amphiphilic Janus Twin Single‐Chain Nanoparticles
Authors: Ji Xiaotian , Zhang Yue , Zhao Hanying 
Published: January 2018

AbstractIn these years, synthesis and self‐assembly of nanoparticles with various sizes, geometries and compositions have aroused great interest due to their scientific significance and potential applications. The nanoparticles with asymmetric structures are able to self‐assemble into hierarchical structures for constructing functional materials. To investigate the self‐assembly behaviors of the nano‐sized asymmetric polymer particles, synthesis and self‐assembly of twin single‐chain nanoparticles (TSCNPs), a type of covalently bonded SCNPs, are reported in this research. A block copolymer with pendant anthracene groups and bromines on two blocks were synthesized by two‐step reversible addition‐fragmentation chain transfer polymerization. After two‐step intramolecular cross‐linking reactions, anthracene photodimerization and atom transfer radical coupling, TSCNPs were prepared. The amphiphilic TSCNPs possess surfactant properties. Upon addition of the TSCNPs, the surface tension of water is reduced. In aqueous solution, the TSCNPs self‐assemble into vesicles with the hydrophobic particles in the inner walls and the hydrophilic particles on the surfaces.