bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Durability of Training Program Dynamic Neuromuscular Stabilization on Strength, Endurance, and Flexibility of Adults with intellectual disabilities
Authors: Babagoltabar-Samakoush Hamed , Aminikhah Behnoosh , Bahiraei Saeid 
Published: October 2024

Abstract

Individuals with intellectual disabilities (ID) often exhibit lower levels of physical fitness compared to the general population, including reduced strength, endurance, flexibility, and coordination. Dynamic neuromuscular stabilization (DNS) training has been proposed as a potential intervention to improve physical fitness in this population, but the effectiveness and durability of DNS training on specific fitness components have not been well-established. This study employed a randomized controlled trial design to investigate the effects of an 8-week DNS training program on the strength, endurance, and flexibility of adults with ID. A total of 31 participants were randomly assigned to either an intervention group (n=16) or a control group (n=15). Muscular strength, endurance, and flexibility were assessed at baseline (pre-test), immediately after the intervention (post-test), and 2 months following the intervention (follow-up) using the 30-second chair stand (30sCS) test, sit-ups test, trunk lift test, and chair sit-and-reach test. Participants in the intervention group engaged in the DNS training program for 8 weeks, with 3 sessions per week, while the control group maintained their usual activities. The analysis of the outcome measures revealed significant time, group, and time-group interaction effects. Post-hoc analyses indicated that the DNS group exhibited significantly greater improvements in 30sCS, sit-ups, trunk lift, and chair sit-and-reach compared to the control group (p<0.01). These improvements were maintained at the 2-month follow-up assessment in the DNS group. This randomized controlled trial demonstrates that an 8-week DNS training program significantly improves muscular strength, endurance, and flexibility in adults with ID, with benefits maintained at a 2 month follow-up. Further research is needed to replicate these findings and investigate underlying mechanisms, but the study highlights the potential of DNS training to promote physical fitness and well-being in individuals with ID.
The 11-month precursory fault activation of the 2019 Mw 5.0 earthquake in the Weiyuan shale gas field, China
Authors: Yang Hongfeng , Zi Jinping , Yang Yuyun , Su Jinrong 
Published: October 2024

Abstract

Anthropogenic activities such as hydraulic fracturing (HF) can trigger destructive earthquakes, the triggering mechanisms of which are still largely in debate. We utilize near-fault seismic recordings to study the preparatory phase of the 2019 Mw 5.0 earthquake in the Weiyuan shale gas field, Sichuan Basin, China, which struck 3 months after stimulation completion. This is one of the largest HF-triggered earthquakes worldwide. We observe an 11-month long precursory fault activation, during which continuous seismicity illuminated the fault plane and provided warnings for a potential destructive earthquake. The fault activation is a consequence of injections in multiple HF well pads, with a variety of mechanisms at play. Numerical simulation reveals that the occurrence of the mainshock involves stress perturbation from post-injection aseismic slip. This work promotes our understanding of HF-induced earthquakes and suggests incorporating long-term near-fault observations and taking post-injection aseismic slip into account for effective hazard management.
Nonlinear Enhancement of Measurement Precision via a Hybrid Quantum Switch
Authors: Li Chuan-Feng , Chen Lei , Yang Yu-Xiang , Li Gong-Chu , hong Xu-Song , Zhang Si-Qi , Xu Hua-Qing , Liu Yuan-Cheng , Chiribella Giulio , Chen Geng , Guo Guangcan 
Published: October 2024

Abstract

Quantum metrology promises measurement precision beyond the classical limit by using suitably tailored quantum states and detection strategies. However, scaling up this advantage is experimentally challenging, due to the difficulty of generating high-quality large-scale probes. Here, we build a photonic setup that achieves enhanced precision scaling by manipulating the probe’s dynamics through operations performed in a coherently controlled order. Our setup applies an unknown rotation and a known orbital angular momentum increase in a coherently controlled order, in a way that reproduces a hybrid quantum SWITCH involving gates generated by both discrete and continuous variables. The unknown rotation angle θ is measured with precision scaling as 1/4ml when a photon undergoes a rotation of 2mθ and an angular momentum shift of 2lℏ. With a practical enhancement factor as high as 2317, the ultimate precision in our experiment is 0.0105′′ when using 7.16 × 107 photons, corresponding to a normalized precision of ≈ 10−4rad per photon. No photon interaction occurs in our experiment, and the precision enhancement consumes only a linearly increasing amount of physical resources while achieving a nonlinear scaling of the precision.
Ultrasound-guided closed reduction of pediatric distal radial physeal fractures
Authors: Wu Xing , Meng Xijun , Wang Si , Shen Xiantao 
Published: October 2024

Abstract

Background: Distal radial physeal fractures are the most common type of physeal fracture. However, few studies have been dedicated to the role of ultrasound-guided closed reduction in these fractures. This study aimed to investigate the utility of ultrasound-guided closed reduction in paediatric distal radial physeal fractures.
Methods:Consecutive patients undergoing ultrasound-guided closed reduction of fractures in our department between November 2017 and October 2019 were included. The adequacy of realignment according to the ultrasound and radiography was recorded.
Results:A total of 51 patients were included in the study. Closed reduction was successfully achieved in all cases who underwent ultrasound-guided cases. The sensitivity for confirming successful anatomical manipulation with ultrasound was 95.3% (95% CI: 82.9～99.2%), while the specificity was 87.5% (95% CI: 46.7～99.3%). The positive predictive value (PPV) was 97.6% (95% CI: 85.9～99.9 %), and the negative predictive value (NPV) was 77.8% (95% CI: 40.2～96.1 %). The corresponding positive and negative likelihood ratios were 7.63 (95% CI: 1.22～47.77) and 0.05 (95% CI: 0.01～0.21). There was a high level of agreement between ultrasound and radiographs assessments of anatomical reduction [κ: 0.788 (±0.117)]. Redisplacement occurred in threecases (5.9%) based on radiographic assessment with one case being a Salter-Harris type I injury and two cases being a Salter-Harris type II injury. At the final follow-up, all fractures had healed, resulting in excellent cosmesis without any other complications.
Conclusions: Our data suggest that ultrasound-guided closed reduction can be considered an excellent alternative method for the treatment of distal radial physeal fractures.
What is Coconut Water?: commodification, globalization and place
Authors: Steckley Marylynn 
Published: October 2024

Abstract

The globalization of coconut water in the past two decades has made it a multi-billion-dollar industry. Since the early 2000s, the beverage has gone from one consumed mostly in producer countries to one processed and shipped all over the world. In this paper, I explore the commodification and globalization of coconut water, illustrating how the material qualities of coconut — the species and maturity— influence its nutrition and taste in ways that conflict with discourses of coconut water as a natural health beverage, and the labour and productive conditions that shape and are shaped by its globalization. I draw from field research conducted in Thailand to ultimately illustrate that processes of commodification are in flux, and the case of coconut water illustrates that the relationship between global stories about coconut water and the ecological and labour conditions that underlie production are not only dialectical but still being negotiated. Ethics Statement: All procedures performed in studies involving human participants were approved by and are in accordance with the ethical standards of the Carleton University Research Ethics Board-A (CUREB-A). CUREB-A is constituted and operates in compliance with the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (TCPS2). Informed Consent and Consent to Publish: Informed consent was obtained from all individual participants included in the study, including consent to publish the photos included in this article.
Data Availability Statement:
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study
Angioimmunoblastic T-cell lymphoma harboring a t(8;14)(q24;q11.2)/TCR::MYC translocation that presented with intestinal infiltration
Authors: Ichikawa Satoshi , Kato Hiroki , Morota Naoya , Abe Hiroaki , Kawajiri Akihisa , Inokura Kyoko , Onodera Koichi , Onishi Yasushi , Fukuhara Noriko , Sato Satoko , Fujishima Fumiyoshi , Ichinohasama Ryo , Harigae Hideo 
Published: October 2024

Abstract

Although rearrangement of the MYC oncogene (MYC-R) is frequently observed in aggressive B-cell lymphomas, it is extremely rare in T-cell malignancies. A 64-year-old man who had been under observation for several years because of asymptomatic pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue(MALToma) was admitted to our hospital because of poor general condition and hypotension. Blood tests revealed thrombocytopenia and elevated serum lactate dehydrogenase levels, whereas computed tomography revealed systemic lymphadenopathy and splenomegaly. An inguinal lymph node biopsy precipitated a diagnosis of angioimmunoblastic T-cell lymphoma (AITL). Shortly after admission, the patient experienced spontaneous intestinal perforation and hemorrhage caused by multiple intestinal infiltrations of the AITL. Although chemotherapy was administered, the patient died several weeks after admission. A 46,XY,t(8;14)(q24;q11.2) karyotype was identified, and fluorescence in situ hybridization analyses showed split signals for the MYC and T-cell receptor (TCR) alpha genes, by which a TCR::MYC translocation was confirmed. Pathological autopsy analysis revealed systemic infiltration of the AITL and no MALToma lesions. Only a few cases of mature T-cell lymphoma harboring MYC-R have been reported in the literature thus far. To the best of our knowledge, this is the first reported case of AITL with TCR::MYC rearrangement. This condition could be associated with refractoriness to chemotherapy and aggressive clinical course with systemic infiltrationthat included the intestine.
The Effect of Mixed Natural Sounds on Stress Recovery: Insights into Physiological Benefits and Temporal Dynamics
Authors: Liu Zhengkui , Zhu Zhengqing 
Published: October 2024

Abstract

The effect of natural sound on stress recovery is heterogeneous. The combination mode of natural sounds and sound duration may affect stress recovery. We conducted a study with 104 participants, randomly assigning them to one of three groups. Each group underwent an adapted version of the Montreal Imaging Stress Test (MIST) to induce stress, followed by a rest stage where they were exposed to either a single natural sound, a mixed sound environment, or no sound at all. Physiological data and self-reported stress levels were recorded at baseline, during the MIST test and the rest stages, and were analyzed using a Generalized Additive Model (GAM). Our findings revealed that the mixed sound environment was more effective in promoting physiological stress recovery, with a consistent recovery time course observed across all participant groups. Our study provides valuable insights and practical guidelines for stress management.
A Prospective Feasibility Study to Differentiate Sacral Neuromodulation Lead Electrode Configurations Using Motor and Sensory Thresholds and Locations of Sensation
Authors: He Tianyu , Hornung Christopher , Evans Michael , Zoghbi Stephanie , Chahine Leya , Nazar Fatima A. , Nelson Dwight , Nakib Nissrine 
Published: October 2024

Abstract

Background
Accurate positioning and effective programming of sacral neuromodulation (SNM) relies upon the use of several acute stimulation measurements. While the clinical utility of these acute measurements including pelvic floor motor thresholds (PFMT), toe/leg motor thresholds (TMT), and sensory thresholds (ST), are widely accepted, their usefulness in quantitative research remains unclear. The purpose of this prospective study was to test these measurements and gauge their utility in future research.
Methods
Eight participants received Axonics SNM, 6 Medtronic Interstim II, and 2 Medtronic Micro SNM. PFMT was measured after implantation. ST and the location of sensation (LOS) were measured immediately postoperatively (PO), at pre-release from the surgery center (PR), and during a follow-up clinic visit (FU). Thresholds were compared across contact and time using linear mixed-effects models.
Results
Significant differences in PFMT were found across electrode configurations, with stimulation through proximal contacts exhibiting lower PFMT than distal configurations. ST displayed no significant differences across electrodes and showed minimal changes over time. LOS exhibited substantial variability across patients and periods.
Conclusions
Results suggest that PFMT were able to differentiate differences across electrode configurations that may be useful for future quantitative research. The lack of differences in ST and LOS across electrode configurations was interesting given the focus on these measurements clinically. Future testing is to confirm these limitations.
Association between preoperative blood–brain barrier dysfunction and postoperative delirium in older patients undergoing cardiac surgery: a prospective cohort study
Authors: Di Lichao , Huang Peiying , He Yeju , Li Jie , Liu Yu , Chi Liwei , Sun Na , Kang Rongtian , Huang Lining 
Published: October 2024

Abstract

Background
Previous research indicates that the breakdown of the blood-brain barrier (BBB) is an early biomarker of cognitive dysfunction in humans, and it deteriorates with age. Patients with coronary heart disease may have concomitant impairment of the BBB. The off-pump coronary artery bypass grafting (OPCABG) is an effective surgical strategy for myocardial revascularization. However, cardiac surgery leads to a high incidence of postoperative delirium (POD), which can seriously affect clinical recovery. Therefore, it is important to explore whether preoperative BBB dysfunction is associated with POD in older patients undergoing OPCABG.
Methods
A prospective observational study was performed on OPCABG patients. Fifty older patients with coronary heart disease were recruited. Before surgery, patients underwent Gadolinium-enhanced magnetic resonance imaging. BBB was assessed using GE AW4.7 workstation GEN IQ module. The physiological parameter volume transfer constant (Ktrans) is the most common and classical method for assessing BBB in the neuroimaging. All patients underwent standardized anesthetic management. Participants were assessed for POD twice daily for 5 days using the 3-Minute Diagnostic Confusion Assessment Method (3D-CAM) in non-intubated patients or the CAM for the Intensive Care Unit in intubated patients.
Results
19 patients (38%) were diagnosed with POD. The preoperative median hippocampus Ktrans of the POD and NPOD patients were 5.36 (IQR, 3.99,8.39) ×10-3min-1, and 3.89 (IQR, 3.40,4.68) ×10-3min-1. The preoperative median thalamus Ktrans of the POD and NPOD patients were 4.80 (IQR, 3.60,6.62) ×10-3min-1, and 3.55 (IQR, 3.05,4.57) ×10-3min-1. Hippocampal and thalamic Ktrans were statistically higher in the POD group compared to the NPOD group (P = 0.012 and P = 0.017). Univariable logistic regression analysis revealed that higher hippocampus Ktrans (OR, 1.350; 95%CI, 1.048–1.740; P = 0.020) and thalamus Ktrans (OR, 1.466; 95%CI, 1.017–2.113; P = 0.040) were significantly associated with higher odds of POD. Multivariable logistic regression analysis, adjustment variables were age, interleukin-6. The adjusted models revealed that preoperative hippocampus Ktrans (OR, 1.250; 95%CI, 0.859–1.817; P = 0.244) and thalamus Ktrans (OR, 1.164; 95% CI, 0.648–2.090; P = 0.611) were not associated with higher odds of POD.
Conclusion
POD patients have higher preoperative hippocampal and thalamic BBB permeability, but this was not an independent risk factor for POD.
Urolithin A mitigates behavioral and synaptic deficits associated with epilepsy through VDAC-1 inhibition: A novel treatment approach
Authors: MISHRA SHEFALI , Verma Vijaya , Pradhan Sambit , Dwivedi Manish , Jorwal Pooja , Gowda Varun , Vasudevan Madavan , Sikdar Sujit , Kumar Vimlesh , Thilagar Pakkirisamy , Clement James , Nongthomba Upendra 
Published: October 2024

Abstract

The persistence of drug-resistant epilepsy indicates the need for new therapeutic interventions against novel targets with reduced side effects. One such approach is modifying underlying pathophysiological mechanisms of synaptic plasticity, contributing to the reduced seizure threshold. We show that the administration of Urolithin-A (UA), a small molecule of natural origin, mitigates behavioral and synaptic dysfunctions under chemically and genetically induced epileptic conditions in Drosophila. Additionally, chronic treatment with UA attenuates the altered basal synaptic transmission and single-cell post-synaptic currents, curtailing the deleterious consequences of PTZ-induced chronic kindling of mice. However, UA exerts no seizure-suppressive effects in in-vitro epileptic conditions, implying the absence of acute symptomatic anti-epileptic effects. Here, we identify the direct interactor of UA as the complex of tubulin dimer and VDAC1 through affinity-purification with synthesized UA-attached beads and transcriptomics studies. Finally, neuron specific VDAC1 knockdown in Drosophila mimics UA supplementation effects. VDAC1 inhibition through UA offers new hope as a distinct neuroprotective therapeutic intervention for refractory epilepsy.
Exploiting Potential Molecular Compounds for Treating Testicular Seminoma by Targeting Immune Related Genes
Authors: Cui Yankang , Zhou Xiaodie , Zhang Jing , Fang Bo , Ge Jingping , Tang Hao , Liu Bianjiang , He Haowei , Xu Feng , Shang Xuejun 
Published: October 2024

Abstract

Background
In cases of advanced seminoma, up to 30% of patients may manifest cisplatin resistance, necessitating aggressive salvage therapy, with a consequent 50% risk of mortality attributable to cancer. Nevertheless, beyond chemotherapy, no further therapeutic modalities have been implemented for these patients.
Methods
The study commenced with the identification of differentially expressed immune-related genes, which were subsequently subjected to clustering using WGCNA. Prognostic signature construction ensued through the execution of univariable Cox regression, lasso regression, and multivariable Cox regression analyses. To validate the prognostic signature, the TCGA-TGCT and GSE99420 cohorts were employed, with assessments conducted via PFS, C-index, DCA, and ROC analyses. Subsequent exploration of the immune landscape and potential immunotherapeutic applications was undertaken through Cibersort and TIDE analyses. Molecular docking and dynamics simulation techniques were then employed for screening potential molecular compounds. Validation of these findings was pursued through in vitro and vivo assays.
Results
CTLA4, SNX17, and TMX1 were selected to construct the signature. Patients in the high-risk group exhibited diminished progression-free survival rates. The AUC for predicting survival at 1, 3, and 5 years was 0.802, 0.899, and 0.943, respectively, surpassing those of other risk factors, such as lymphovascular invasion and T stage. The C-index for the risk score was 0.838. Decision curve analysis (DCA) suggests that incorporating lymphovascular invasion and the risk score yields the most favorable decision-making outcomes for patients. Moreover, individuals classified as high-risk may derive greater benefit from immunotherapy. Molecular compounds including Rutin, ICG-001, and Doxorubicin can selectively target CTLA4, SNX17, and TMX1, respectively, thereby inhibiting the proliferation and invasive capabilities of seminoma tumor cells in vitro and vivo.
Conclusion
The signature initially constructed based on immune-related genes shows promise for predicting outcomes and assessing the efficacy of immunotherapy in seminoma patients. Rutin, ICG-001, and Doxorubicin have demonstrated potential to target these signature genes and inhibit tumor cell viability.
Treatment with trypLE before freezing improves thawing integrity and functionality of sheep ovarian tissue
Authors: Marco Alicia , Gargallo Marta , Ciriza Jesús , Royo-Cañas María , Ibañez-Deler Alejandro , Remacha Ana Rosa , Fons-Contreras María , Malo Clara 
Published: October 2024

Abstract

Objective: To study innovative approaches to ovarian tissue cryopreservation, a critical issue for fertility preservation in pediatric cancer patients. Despite historical attempts, recent advances in cancer treatment have underscored the urgent need for more effective and reliable ovarian tissue cryopreservation methods. Our research aims to evaluate if decreasing the rigidity of stroma before cryopreservation by investigating pre-treatments with enzymes can enhance the quality of ovarian tissue post-thawing.
Design: Our research evaluated the use of five commonly used enzymes to disaggregate tissue (trypLE, collagenase, dispase, accutase and hyaluronidase) before freezing ovarian tissue to decrease rigidity and facilitate cryopreservation. Sheep ovaries, with high similarity to human ovaries, were used as an animal model. Tissue structure, cell proliferation, apoptosis and viability were assessed before and after thawing.
Results: Our findings showed that enzymatic treatment with trypLE before freezing offered immediate benefits post-thawing with the highest viability values and percentage of intact follicles. However, 2 and 7 days after thawing and culture, dispase showed the highest viability but with loci of necrosis at the edges and more damaged follicles compared to trypLE. A decrease in viability was observed after thawing and culturing the samples. The pretreatment with accutase damaged the tissue severely with also the lowest viability values. Ki67-positive follicles and stromal cells were observed in fresh samples, but only trypLE and hyaluronidase maintained Ki67-positive antral follicles after 2 days culture. Besides, only trypLE maintained all follicles negative to caspase-3 after thawing, and 7 days after culture primordial follicles were apoptotic in all treatments apart from trypLE.
Conclusion: our findings suggest that trypLE pretreatment could provide a beneficial approach for maintaining the functions and viability of cryopreserved ovaries after thawing. Further research is needed to fully understand their impact and optimize cryopreservation protocols in this important clinical context.